# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Fig1 PF12351.8 EDK35903.2 - 1.5e-05 25.0 5.2 1.5e-05 25.0 5.2 2.3 3 0 0 3 3 3 1 Ca2+ regulator and membrane fusion protein Fig1 Vma12 PF11712.8 EDK35903.2 - 2 8.5 7.6 14 5.8 7.6 2.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Asp PF00026.23 EDK35904.2 - 2.1e-59 201.5 5.9 5.3e-59 200.2 5.9 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDK35904.2 - 2.6e-07 31.2 0.3 0.037 14.7 0.1 3.6 3 0 0 3 3 3 2 Aspartyl protease TAXi_N PF14543.6 EDK35904.2 - 3.3e-07 30.7 0.9 1.3e-06 28.8 0.9 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EDK35904.2 - 2.5e-06 27.9 0.0 0.21 12.2 0.0 3.7 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease MARVEL PF01284.23 EDK35905.2 - 1.5e-11 44.5 20.3 2e-11 44.1 20.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF676 PF05057.14 EDK35906.2 - 0.089 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DCR PF14047.6 EDK35907.1 - 0.2 11.9 2.6 0.55 10.5 2.1 2.0 1 1 0 1 1 1 0 Dppa2/4 conserved region DUF2264 PF10022.9 EDK35908.2 - 1.4e-113 379.6 0.0 1.9e-113 379.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) CooC_C PF15976.5 EDK35908.2 - 0.034 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 CS1-pili formation C-terminal BNR_4 PF15892.5 EDK35909.2 - 3.2e-12 46.4 0.2 5e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 BNR repeat-containing family member BNR_4 PF15892.5 EDK35910.2 - 1.7e-52 178.5 0.6 2.1e-52 178.2 0.6 1.0 1 0 0 1 1 1 1 BNR repeat-containing family member Glyco_hydro_2_C PF02836.17 EDK35911.2 - 3.5e-101 338.3 0.0 5.5e-101 337.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EDK35911.2 - 1.5e-53 181.9 0.0 2.5e-53 181.2 0.0 1.3 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EDK35911.2 - 8.3e-40 136.5 0.5 1.7e-39 135.5 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 EDK35911.2 - 7.8e-10 39.1 0.0 2.4e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 EDK35911.2 - 4.3e-09 37.0 8.9 1.3e-08 35.5 0.0 3.0 3 0 0 3 3 3 2 Glycosyl hydrolases family 2 Bac_A_amyl_C PF18612.1 EDK35911.2 - 0.15 11.8 0.1 3.9 7.3 0.0 3.0 3 0 0 3 3 3 0 Bacterial Alpha amylase C-terminal domain Sugar_tr PF00083.24 EDK35912.2 - 5.4e-70 236.5 23.2 6.7e-70 236.2 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK35912.2 - 1.5e-25 89.9 19.4 1.5e-25 89.9 19.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EDK35912.2 - 4.3e-09 35.4 12.5 5.2e-05 22.0 3.7 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein TRI12 PF06609.13 EDK35912.2 - 5.8e-07 28.3 0.8 5.8e-07 28.3 0.8 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ABC2_membrane PF01061.24 EDK35913.2 - 6.2e-43 146.7 23.0 6.2e-43 146.7 23.0 2.2 3 0 0 3 3 3 1 ABC-2 type transporter PDR_CDR PF06422.12 EDK35913.2 - 3.9e-32 110.0 0.1 3.9e-32 110.0 0.1 2.4 2 0 0 2 2 1 1 CDR ABC transporter ABC_tran PF00005.27 EDK35913.2 - 4.2e-32 111.5 0.0 1.3e-19 71.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 EDK35913.2 - 1.3e-20 73.8 0.0 4e-20 72.2 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EDK35913.2 - 2e-08 34.3 0.0 8.9e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EDK35913.2 - 1.2e-06 28.2 0.3 0.00015 21.4 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDK35913.2 - 3.1e-06 27.8 0.7 0.045 14.3 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EDK35913.2 - 4.1e-05 23.2 0.3 0.13 12.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK35913.2 - 6.7e-05 23.3 0.1 0.014 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EDK35913.2 - 0.00062 19.7 0.8 2.7 7.9 0.1 3.3 3 0 0 3 3 3 1 NACHT domain ABC2_membrane_3 PF12698.7 EDK35913.2 - 0.00071 18.8 16.0 0.001 18.3 14.6 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_28 PF13521.6 EDK35913.2 - 0.0013 19.0 1.2 0.13 12.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK35913.2 - 0.0015 18.3 0.6 1.4 8.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDK35913.2 - 0.0063 16.8 2.5 0.39 11.0 0.1 3.0 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EDK35913.2 - 0.0066 16.5 0.5 0.78 9.9 0.2 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EDK35913.2 - 0.0073 16.9 0.5 3 8.4 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.6 EDK35913.2 - 0.0093 16.4 0.4 15 6.0 0.1 3.4 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 EDK35913.2 - 0.011 15.4 2.2 0.64 9.6 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_ATPase PF09818.9 EDK35913.2 - 0.014 14.2 0.7 0.24 10.1 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 EDK35913.2 - 0.021 15.0 0.2 4.4 7.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EDK35913.2 - 0.025 14.4 0.2 1.1 9.0 0.0 2.9 3 0 0 3 3 3 0 Deoxynucleoside kinase AAA_19 PF13245.6 EDK35913.2 - 0.038 14.3 0.2 9.4 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 EDK35913.2 - 0.091 12.1 0.0 3.8 6.8 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain DUF2070 PF09843.9 EDK35913.2 - 0.86 7.8 8.5 1.4 7.2 8.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ABC2_membrane PF01061.24 EDK35914.1 - 8.9e-44 149.4 24.5 8.9e-44 149.4 24.5 2.0 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 EDK35914.1 - 0.00021 21.1 0.2 0.00021 21.1 0.2 2.3 3 0 0 3 3 3 1 CDR ABC transporter zf-Sec23_Sec24 PF04810.15 EDK35914.1 - 0.01 15.9 0.9 0.028 14.5 0.1 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Ferlin_C PF16165.5 EDK35914.1 - 0.063 13.2 0.3 0.063 13.2 0.3 2.0 2 0 0 2 2 2 0 Ferlin C-terminus SMC_N PF02463.19 EDK35914.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 EDK35914.1 - 4 6.4 23.3 41 3.1 23.1 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein Fungal_trans_2 PF11951.8 EDK35915.2 - 3.4e-36 124.9 4.1 4.9e-36 124.4 4.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK35915.2 - 3e-09 36.8 9.5 8e-09 35.5 9.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 EDK35916.2 - 3.3e-39 135.5 0.0 4.1e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDK35916.2 - 0.0001 22.5 0.0 0.00024 21.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK35916.2 - 0.00056 19.2 0.0 0.0045 16.3 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDK35916.2 - 0.00096 18.3 0.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EDK35916.2 - 0.025 13.7 0.0 0.29 10.2 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 EDK35916.2 - 0.16 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Glu_dehyd_C PF16912.5 EDK35916.2 - 0.21 11.0 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 EDK35916.2 - 0.21 11.8 0.0 0.51 10.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Thi4 PF01946.17 EDK35916.2 - 0.23 10.7 0.0 0.35 10.1 0.0 1.2 1 0 0 1 1 1 0 Thi4 family ATG22 PF11700.8 EDK35917.2 - 6.3e-107 358.2 22.5 7e-107 358.0 22.5 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EDK35917.2 - 9.8e-06 24.7 5.8 9.8e-06 24.7 5.8 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.16 EDK35917.2 - 0.00043 18.6 6.8 0.00043 18.6 6.8 1.8 2 0 0 2 2 2 1 BT1 family Fungal_trans_2 PF11951.8 EDK35918.2 - 0.00019 20.4 0.8 0.00024 20.1 0.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EDK35919.2 - 1.7e-14 53.5 0.4 2.1e-14 53.1 0.4 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain V_cholerae_RfbT PF05575.11 EDK35919.2 - 0.037 13.3 0.2 0.054 12.8 0.2 1.4 1 0 0 1 1 1 0 Vibrio cholerae RfbT protein DAO PF01266.24 EDK35920.2 - 3e-31 109.3 0.0 3.4e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDK35920.2 - 0.00032 20.9 1.0 0.0025 18.0 0.3 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EDK35920.2 - 0.00088 19.7 0.0 0.0016 18.9 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 EDK35920.2 - 0.001 18.3 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EDK35920.2 - 0.0013 18.4 0.4 0.0023 17.6 0.4 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EDK35920.2 - 0.0039 17.7 0.4 0.0083 16.7 0.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 EDK35920.2 - 0.0047 16.4 0.0 0.29 10.6 0.0 2.7 2 1 1 3 3 3 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 EDK35920.2 - 0.015 14.9 0.8 0.063 12.9 0.5 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EDK35920.2 - 0.026 14.6 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EDK35920.2 - 0.043 13.1 0.3 0.076 12.3 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 EDK35920.2 - 0.066 12.6 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 ThiF family Sacchrp_dh_NADP PF03435.18 EDK35920.2 - 0.07 13.4 0.1 0.15 12.4 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 EDK35920.2 - 0.072 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDK35920.2 - 0.072 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EDK35920.2 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain ATG22 PF11700.8 EDK35921.2 - 2.7e-132 441.8 23.5 3.1e-132 441.6 23.5 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like BT1 PF03092.16 EDK35921.2 - 0.015 13.6 9.8 0.02 13.1 8.9 1.7 1 1 0 1 1 1 0 BT1 family ApbA PF02558.16 EDK35922.2 - 2.7e-28 98.5 0.1 3.7e-28 98.1 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EDK35922.2 - 7.1e-28 97.3 0.0 3.3e-27 95.1 0.0 2.0 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal bZIP_1 PF00170.21 EDK35923.2 - 1e-05 25.5 10.3 1e-05 25.5 10.3 1.6 2 0 0 2 2 2 1 bZIP transcription factor HALZ PF02183.18 EDK35923.2 - 0.0055 16.9 0.2 0.015 15.5 0.2 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper bZIP_2 PF07716.15 EDK35923.2 - 0.022 14.8 14.5 0.044 13.9 14.5 1.4 1 0 0 1 1 1 0 Basic region leucine zipper DUF5595 PF18077.1 EDK35923.2 - 0.045 13.8 2.5 0.088 12.9 1.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) JAKMIP_CC3 PF16034.5 EDK35923.2 - 0.083 12.8 5.9 0.15 12.0 5.9 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain DivIC PF04977.15 EDK35923.2 - 0.17 11.7 3.1 0.41 10.4 2.1 2.3 1 1 0 1 1 1 0 Septum formation initiator adh_short PF00106.25 EDK35924.2 - 6.1e-27 94.3 0.1 8.6e-27 93.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK35924.2 - 1.1e-17 64.4 0.0 1.6e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK35924.2 - 4.1e-06 26.8 0.0 8.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK35924.2 - 1.1e-05 25.5 0.1 1.5e-05 25.0 0.1 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDK35924.2 - 0.0012 18.4 0.2 0.0021 17.7 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EDK35924.2 - 0.0016 17.9 0.2 0.0084 15.6 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EDK35924.2 - 0.01 15.0 0.5 0.046 12.9 0.5 2.4 1 1 0 1 1 1 0 Male sterility protein bZIP_1 PF00170.21 EDK35925.2 - 5.7e-09 35.9 6.7 1.2e-08 35.0 6.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor HALZ PF02183.18 EDK35925.2 - 0.013 15.7 0.3 0.03 14.5 0.3 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 EDK35925.2 - 0.015 15.1 2.9 0.022 14.5 1.8 1.9 1 1 1 2 2 2 0 Septum formation initiator Sec63 PF02889.16 EDK35925.2 - 0.023 13.8 0.5 0.03 13.5 0.5 1.2 1 0 0 1 1 1 0 Sec63 Brl domain DUF4200 PF13863.6 EDK35925.2 - 0.04 14.3 5.1 0.067 13.6 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) bZIP_2 PF07716.15 EDK35925.2 - 0.068 13.3 9.3 0.12 12.4 9.3 1.4 1 0 0 1 1 1 0 Basic region leucine zipper MukF_C PF17193.4 EDK35925.2 - 0.24 11.5 2.9 0.97 9.6 0.1 2.0 1 1 1 2 2 2 0 MukF C-terminal domain FlaC_arch PF05377.11 EDK35925.2 - 9.4 6.7 7.6 3.4 8.1 4.4 2.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) adh_short PF00106.25 EDK35926.1 - 4e-26 91.7 0.0 5.9e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK35926.1 - 9.3e-19 67.9 0.0 1.3e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK35926.1 - 5.2e-09 36.3 0.0 1.5e-08 34.8 0.0 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EDK35926.1 - 8.7e-08 32.3 0.1 1.2e-07 31.8 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK35926.1 - 5.3e-05 22.8 0.0 0.00026 20.5 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDK35926.1 - 0.00069 19.2 0.1 0.0011 18.5 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EDK35926.1 - 0.0015 17.7 1.0 0.016 14.4 1.0 2.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK35926.1 - 0.026 13.9 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AA_permease_2 PF13520.6 EDK35927.2 - 2.3e-16 59.7 12.4 2.8e-16 59.4 12.4 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3444 PF11926.8 EDK35927.2 - 0.029 14.0 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3444) DUF5045 PF16464.5 EDK35927.2 - 0.16 12.3 0.1 0.27 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5045) AA_permease_2 PF13520.6 EDK35928.2 - 2.8e-38 131.9 32.1 3.1e-38 131.7 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK35928.2 - 0.00063 18.4 26.7 0.00096 17.8 26.7 1.4 1 1 0 1 1 1 1 Amino acid permease DUF4190 PF13828.6 EDK35928.2 - 0.14 11.9 6.9 0.94 9.3 0.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) CAP PF00188.26 EDK35929.2 - 2.6e-15 57.4 5.6 2.6e-15 57.4 5.6 2.0 2 1 0 2 2 2 1 Cysteine-rich secretory protein family RAP1 PF07218.11 EDK35929.2 - 2.9 6.0 3.6 3.7 5.7 3.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PA_decarbox PF05870.11 EDK35930.1 - 2.5e-22 79.2 0.5 3.2e-22 78.8 0.5 1.0 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) MoaF PF10703.9 EDK35930.1 - 2.8e-06 27.2 0.0 4.2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 MoaF N-terminal domain MoaF_C PF17409.2 EDK35930.1 - 0.0012 18.5 0.3 0.0015 18.2 0.3 1.2 1 0 0 1 1 1 1 MoaF C-terminal domain CRAL_TRIO PF00650.20 EDK35931.2 - 1.1e-29 103.2 0.1 2.2e-29 102.2 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDK35931.2 - 0.00028 21.1 0.0 0.00064 19.9 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK35931.2 - 0.0092 16.1 0.0 0.028 14.6 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain PHD PF00628.29 EDK35932.2 - 0.0001 22.1 6.9 0.00019 21.3 6.9 1.5 1 0 0 1 1 1 1 PHD-finger FIVAR PF07554.13 EDK35932.2 - 0.034 14.9 0.8 0.09 13.6 0.7 1.8 1 1 0 1 1 1 0 FIVAR domain zf-HC5HC2H PF13771.6 EDK35932.2 - 0.061 13.6 1.3 0.13 12.5 1.1 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain UTP15_C PF09384.10 EDK35933.2 - 3.6e-44 150.0 0.0 5.9e-44 149.3 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EDK35933.2 - 1.1e-09 38.7 7.2 0.17 12.8 0.1 6.5 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK35933.2 - 5.9e-08 32.9 0.0 1.3 9.4 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EDK35933.2 - 0.00081 19.4 0.0 0.43 10.6 0.0 3.2 1 1 2 3 3 3 2 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 EDK35934.2 - 3.8e-27 94.0 29.9 2.8e-05 24.8 0.1 10.1 11 0 0 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK35934.2 - 1.2e-15 57.6 0.0 0.00051 20.3 0.0 5.7 3 3 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDK35934.2 - 0.00027 20.1 1.4 0.05 12.6 0.1 3.1 2 1 1 3 3 3 2 Coatomer WD associated region Ge1_WD40 PF16529.5 EDK35934.2 - 0.00068 18.7 0.5 4.3 6.2 0.2 4.0 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 EDK35934.2 - 0.0042 17.1 0.3 2.7 8.1 0.0 3.5 4 0 0 4 4 4 1 WD domain, G-beta repeat Nup160 PF11715.8 EDK35934.2 - 0.0046 15.7 0.0 0.02 13.6 0.1 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PD40 PF07676.12 EDK35934.2 - 0.012 15.5 4.8 21 5.2 0.0 5.5 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF2439 PF10382.9 EDK35934.2 - 0.063 13.6 0.2 0.73 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) CHAP PF05257.16 EDK35934.2 - 0.89 10.2 7.5 0.76 10.4 0.5 3.6 3 2 0 3 3 3 0 CHAP domain Mitofilin PF09731.9 EDK35935.2 - 1.7e-51 175.8 15.0 7.4e-43 147.3 15.1 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein PI3K_P85_iSH2 PF16454.5 EDK35935.2 - 0.00035 20.2 8.5 0.00035 20.2 8.5 2.6 2 1 1 3 3 3 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Prominin PF05478.11 EDK35935.2 - 0.014 13.4 12.1 0.043 11.8 0.6 2.1 1 1 1 2 2 2 0 Prominin DUF4837 PF16125.5 EDK35935.2 - 0.038 13.0 1.7 0.068 12.2 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4837) MAAL_C PF07476.11 EDK35935.2 - 0.071 12.2 0.1 0.19 10.8 0.0 1.7 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Exonuc_VII_L PF02601.15 EDK35935.2 - 0.087 12.4 16.8 4.6 6.7 14.3 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EDK35935.2 - 0.097 12.0 13.7 0.028 13.8 8.7 2.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4407) DUF4790 PF16037.5 EDK35935.2 - 0.13 12.7 0.3 0.43 11.1 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) PqqD PF05402.12 EDK35935.2 - 0.16 12.3 1.2 24 5.3 0.0 3.3 2 1 1 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) ApoLp-III PF07464.11 EDK35935.2 - 0.16 12.0 16.3 0.23 11.5 10.5 3.3 2 1 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Phasin PF05597.11 EDK35935.2 - 0.2 11.6 9.0 0.56 10.2 2.1 3.1 1 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CelTOS PF18659.1 EDK35935.2 - 0.26 11.7 9.0 0.6 10.6 0.7 3.5 4 0 0 4 4 3 0 Cell-traversal protein for ookinetes and sporozoites T3SS_basalb_I PF17001.5 EDK35935.2 - 0.45 11.1 4.0 89 3.8 0.0 3.5 2 1 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI TipAS PF07739.13 EDK35935.2 - 1.3 9.5 4.9 45 4.6 3.4 3.1 1 1 1 3 3 3 0 TipAS antibiotic-recognition domain HSCB_C PF07743.13 EDK35935.2 - 1.7 9.2 17.5 8.5 6.9 0.0 5.0 3 2 2 5 5 5 0 HSCB C-terminal oligomerisation domain ABC_tran_CTD PF16326.5 EDK35935.2 - 2.2 8.6 19.6 18 5.7 0.2 5.5 4 1 1 5 5 5 0 ABC transporter C-terminal domain DUF1664 PF07889.12 EDK35935.2 - 2.3 8.2 10.5 10 6.2 0.1 3.6 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) BMFP PF04380.13 EDK35935.2 - 2.7 8.5 10.2 0.3 11.6 2.8 3.0 3 0 0 3 3 2 0 Membrane fusogenic activity BLYB PF05289.11 EDK35935.2 - 3.4 7.9 10.6 0.54 10.5 1.4 3.3 2 1 1 3 3 3 0 Borrelia hemolysin accessory protein NPV_P10 PF05531.12 EDK35935.2 - 3.7 8.1 11.1 2 8.9 3.2 3.7 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein UPF0184 PF03670.13 EDK35935.2 - 4.1 7.9 8.0 2 8.8 0.7 3.2 2 2 0 2 2 2 0 Uncharacterised protein family (UPF0184) PhaP_Bmeg PF09602.10 EDK35935.2 - 9.8 6.1 17.1 0.21 11.5 0.4 3.4 2 1 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Actin PF00022.19 EDK35936.2 - 1.3e-109 366.5 0.0 1.6e-109 366.2 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDK35936.2 - 0.00032 19.6 0.0 0.43 9.3 0.1 2.3 2 1 0 2 2 2 2 MreB/Mbl protein Alpha-amylase_C PF02806.18 EDK35937.1 - 4.9e-24 84.6 0.2 1.8e-23 82.8 0.1 2.1 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EDK35937.1 - 4.7e-14 52.7 0.5 4.6e-12 46.2 0.1 2.5 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EDK35937.1 - 5.5e-14 52.3 0.1 1.7e-13 50.7 0.1 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Fungal_trans_2 PF11951.8 EDK35938.2 - 0.021 13.7 0.2 0.032 13.1 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Xol-1_N PF09108.10 EDK35938.2 - 0.078 12.8 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal NUP PF06516.11 EDK35938.2 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) Ku PF02735.16 EDK35939.2 - 4.1e-27 95.2 0.0 7.4e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain MMR_HSR1 PF01926.23 EDK35940.2 - 4.4e-13 49.3 0.0 1.5e-12 47.6 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK35940.2 - 2.7e-05 24.1 0.4 9.9e-05 22.3 0.4 1.9 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EDK35940.2 - 0.00017 21.2 0.3 0.0017 17.9 0.3 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 EDK35940.2 - 0.016 14.6 0.2 0.048 13.0 0.0 2.0 2 0 0 2 2 2 0 AIG1 family AAA_24 PF13479.6 EDK35940.2 - 0.031 14.0 0.2 0.33 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EDK35940.2 - 0.074 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Septin IIGP PF05049.13 EDK35940.2 - 0.091 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) MeaB PF03308.16 EDK35940.2 - 0.2 10.6 1.0 2.7 6.9 0.1 2.7 2 2 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EDK35940.2 - 0.21 12.2 0.1 0.21 12.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDK35940.2 - 0.23 11.4 0.7 1 9.3 0.0 2.1 2 0 0 2 2 2 0 NTPase KTI12 PF08433.10 EDK35941.1 - 5.9e-96 321.1 0.2 6.7e-96 320.9 0.2 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EDK35941.1 - 0.00038 20.6 0.6 0.0011 19.2 0.2 2.0 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK35941.1 - 0.0027 18.1 0.0 0.0056 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase CLP1_P PF16575.5 EDK35941.1 - 0.011 15.5 0.4 0.081 12.7 0.0 2.3 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 EDK35941.1 - 0.011 15.8 0.3 0.046 13.8 0.1 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EDK35941.1 - 0.049 13.9 0.0 0.082 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EDK35941.1 - 0.051 13.2 0.2 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.6 EDK35941.1 - 0.063 13.6 0.1 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EDK35941.1 - 0.065 13.1 0.1 0.16 11.9 0.1 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EDK35941.1 - 0.073 13.6 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Utp11 PF03998.13 EDK35942.2 - 5.9e-70 236.0 33.4 6.8e-70 235.8 33.4 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EDK35942.2 - 0.0066 15.8 0.3 0.0066 15.8 0.3 1.8 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 SF1-HH PF16275.5 EDK35942.2 - 0.046 14.1 3.4 0.057 13.7 2.0 1.9 1 1 0 1 1 1 0 Splicing factor 1 helix-hairpin domain RsfS PF02410.15 EDK35943.2 - 4.1e-16 59.2 0.0 2.7e-15 56.6 0.0 2.2 2 0 0 2 2 2 1 Ribosomal silencing factor during starvation Phage_TAC_3 PF06896.11 EDK35943.2 - 0.068 13.8 0.1 0.32 11.6 0.0 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, TAC Drc1-Sld2 PF11719.8 EDK35944.2 - 7.2e-76 256.5 30.2 1.7e-74 252.0 30.2 2.0 1 1 0 1 1 1 1 DNA replication and checkpoint protein zf-C2HC5 PF06221.13 EDK35945.2 - 6e-24 83.8 6.3 9.7e-24 83.1 6.3 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type FYVE PF01363.21 EDK35945.2 - 0.1 12.7 1.4 0.24 11.5 1.4 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf-CCCH PF00642.24 EDK35946.2 - 1e-11 44.5 36.1 0.00011 22.0 2.0 6.0 5 1 1 6 6 6 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK35946.2 - 4.9e-06 26.4 42.9 0.042 13.9 1.7 7.1 6 1 0 6 6 6 5 Zinc finger domain zf-CCCH_3 PF15663.5 EDK35946.2 - 0.0031 17.7 15.9 0.0056 16.9 8.8 3.2 1 1 2 3 3 3 2 Zinc-finger containing family Torus PF16131.5 EDK35946.2 - 0.018 15.7 24.8 1.3 9.8 0.7 5.1 2 1 3 5 5 5 0 Torus domain zf-CCCH_4 PF18044.1 EDK35946.2 - 0.56 10.1 43.5 0.33 10.8 2.4 6.4 5 2 0 5 5 5 0 CCCH-type zinc finger Pkinase PF00069.25 EDK35947.2 - 1.4e-46 159.0 0.0 2.4e-45 155.0 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK35947.2 - 1.6e-23 83.4 0.0 6.8e-23 81.3 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EDK35947.2 - 0.04 13.5 0.2 1.3 8.6 0.1 2.4 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDK35947.2 - 0.11 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase TANGO2 PF05742.12 EDK35948.2 - 2e-29 103.4 0.0 2.2e-29 103.3 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 LIDHydrolase PF10230.9 EDK35949.2 - 1.1e-64 218.6 0.0 1.3e-64 218.4 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EDK35949.2 - 1.1e-05 24.8 0.0 1.3e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK35949.2 - 9.9e-05 23.0 0.0 0.00012 22.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EDK35949.2 - 0.0011 18.6 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DLH PF01738.18 EDK35949.2 - 0.0014 18.2 0.1 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EDK35949.2 - 0.011 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.20 EDK35949.2 - 0.023 14.8 0.0 0.074 13.1 0.0 2.0 1 1 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.13 EDK35949.2 - 0.026 14.4 0.0 0.36 10.6 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Methyltransf_25 PF13649.6 EDK35950.2 - 1.7e-12 47.9 0.0 5.1e-12 46.3 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 EDK35950.2 - 3.9e-12 46.2 0.0 5.7e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDK35950.2 - 7.6e-12 45.3 0.1 2.6e-11 43.6 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK35950.2 - 2.5e-09 37.6 0.0 7.8e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK35950.2 - 2.8e-07 30.5 0.0 4.4e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK35950.2 - 4e-06 26.5 0.0 6.5e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EDK35950.2 - 6.7e-06 25.3 0.1 1e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EDK35950.2 - 1e-05 25.5 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDK35950.2 - 0.00011 21.6 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDK35950.2 - 0.00021 22.0 0.0 0.00051 20.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EDK35950.2 - 0.00047 20.3 0.0 0.00082 19.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EDK35950.2 - 0.0025 17.6 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_32 PF13679.6 EDK35950.2 - 0.0063 16.5 0.0 0.0097 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EDK35950.2 - 0.015 14.8 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB PRMT5 PF05185.16 EDK35950.2 - 0.019 14.9 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.15 EDK35950.2 - 0.036 13.7 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 EDK35950.2 - 0.066 13.0 0.1 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EDK35950.2 - 0.097 13.7 0.0 0.2 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain SelR PF01641.18 EDK35951.2 - 1.3e-49 167.3 0.2 1.5e-49 167.1 0.2 1.0 1 0 0 1 1 1 1 SelR domain TackOD1 PF18551.1 EDK35951.2 - 0.02 14.5 1.6 0.13 11.9 1.6 1.9 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 GFA PF04828.14 EDK35951.2 - 0.033 14.5 0.9 0.39 11.1 0.1 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EDK35951.2 - 0.04 13.9 1.2 0.63 10.1 0.1 2.5 3 0 0 3 3 3 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 EDK35951.2 - 0.052 13.5 1.8 0.64 10.0 2.0 2.4 1 1 1 2 2 2 0 SprT-like zinc ribbon domain DUF3463 PF11946.8 EDK35951.2 - 0.061 13.1 0.0 0.09 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3463) zinc_ribbon_10 PF10058.9 EDK35951.2 - 0.095 12.5 0.4 4.8 7.0 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 EDK35951.2 - 0.12 12.6 0.6 0.36 11.1 0.6 1.8 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Steroid_dh PF02544.16 EDK35952.2 - 3.9e-28 98.3 3.9 7e-28 97.5 3.9 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EDK35952.2 - 0.00079 19.0 2.1 0.0013 18.3 2.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EDK35952.2 - 0.03 14.7 0.6 0.064 13.7 0.6 1.7 1 0 0 1 1 1 0 Phospholipid methyltransferase MBF1 PF08523.10 EDK35953.1 - 5.6e-24 84.4 1.6 5.6e-24 84.4 1.6 1.9 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EDK35953.1 - 2.7e-14 52.9 0.3 9.4e-14 51.2 0.3 1.8 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 EDK35953.1 - 1.1e-06 28.8 0.1 2.8e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 EDK35953.1 - 1.7e-05 24.8 0.2 2.8e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 EDK35953.1 - 0.021 14.8 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MqsA_antitoxin PF15731.5 EDK35953.1 - 0.044 13.9 0.1 0.058 13.5 0.1 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA TRAP-gamma PF07074.12 EDK35953.1 - 0.056 13.0 0.9 0.079 12.5 0.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) HTH_25 PF13413.6 EDK35953.1 - 0.14 12.0 0.1 0.28 11.1 0.1 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain BCDHK_Adom3 PF10436.9 EDK35954.2 - 9.3e-30 103.6 0.3 1.4e-29 103.0 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDK35954.2 - 3.4e-12 46.9 0.0 9.3e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDK35954.2 - 5.9e-05 22.9 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EDK35954.2 - 0.023 14.7 0.0 0.13 12.2 0.0 2.1 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain DUF4404 PF14357.6 EDK35954.2 - 0.035 14.7 0.0 0.091 13.4 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Cupin_8 PF13621.6 EDK35955.2 - 3.4e-10 40.1 0.0 5.9e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain PHD PF00628.29 EDK35955.2 - 3.5e-08 33.2 10.9 6.9e-08 32.3 10.9 1.5 1 0 0 1 1 1 1 PHD-finger JmjC PF02373.22 EDK35955.2 - 5.7e-07 30.0 0.1 1.3e-06 28.9 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase JHD PF17811.1 EDK35955.2 - 1.2e-06 29.0 0.0 2.4e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Jumonji helical domain AraC_binding PF02311.19 EDK35955.2 - 0.0023 17.9 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 EDK35955.2 - 0.017 14.8 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Zf_RING PF16744.5 EDK35955.2 - 0.05 13.7 5.0 0.098 12.8 5.0 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 EDK35955.2 - 0.08 13.2 4.4 0.72 10.1 4.7 2.3 1 1 1 2 2 2 0 PHD-like zinc-binding domain Cupin_1 PF00190.22 EDK35955.2 - 0.087 12.4 0.0 0.26 10.9 0.0 1.7 2 0 0 2 2 2 0 Cupin Cupin_4 PF08007.12 EDK35955.2 - 0.097 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein RecR PF02132.15 EDK35955.2 - 0.82 9.3 4.5 1.8 8.2 4.5 1.5 1 0 0 1 1 1 0 RecR protein Prok-RING_1 PF14446.6 EDK35955.2 - 1.3 9.0 7.1 1.2 9.1 5.8 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 EDK35955.2 - 7 6.8 8.9 18 5.5 8.9 1.8 1 1 0 1 1 1 0 PHD-finger ArAE_2_N PF10337.9 EDK35956.2 - 8.6e-165 549.3 0.9 8.6e-165 549.3 0.9 2.0 2 0 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 EDK35956.2 - 2.6e-81 272.8 0.0 1.5e-80 270.3 0.0 2.1 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 EDK35956.2 - 7.3e-07 29.4 14.5 7.3e-07 29.4 14.5 3.1 3 0 0 3 3 3 1 Fusaric acid resistance protein-like Arginosuc_synth PF00764.19 EDK35957.1 - 7.6e-160 532.4 0.0 8.8e-160 532.2 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EDK35957.1 - 2.7e-05 23.8 0.0 4.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDK35957.1 - 0.00063 18.6 0.0 0.001 17.9 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 EDK35957.1 - 0.072 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Vhr1 PF04001.13 EDK35958.2 - 3.3e-43 145.9 2.5 1.1e-42 144.2 2.5 1.9 1 0 0 1 1 1 1 Transcription factor Vhr1 HEAT PF02985.22 EDK35960.2 - 3.4e-10 39.3 2.2 0.032 14.5 0.0 7.8 9 0 0 9 9 8 2 HEAT repeat HEAT_2 PF13646.6 EDK35960.2 - 1.9e-08 34.6 0.0 0.85 10.1 0.0 7.2 3 2 4 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 EDK35960.2 - 9e-08 32.5 0.1 0.014 15.9 0.1 5.9 5 1 1 6 6 6 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDK35960.2 - 6.3e-06 26.7 0.5 12 6.6 0.0 6.7 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EDK35960.2 - 4.9e-05 22.6 3.0 0.0005 19.3 0.0 3.6 4 1 0 4 4 4 1 RNAPII transcription regulator C-terminal SF3b1 PF08920.10 EDK35960.2 - 0.00013 22.4 2.1 0.0038 17.7 2.1 2.5 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 IFRD PF05004.13 EDK35960.2 - 0.00024 20.3 0.0 1.8 7.6 0.1 3.6 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) DUF3385 PF11865.8 EDK35960.2 - 0.00053 19.9 6.6 0.03 14.2 0.1 5.2 5 2 1 7 7 7 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 EDK35960.2 - 0.0006 19.4 2.4 1.2 8.6 0.3 4.5 4 2 1 6 6 6 1 CLASP N terminal NUC173 PF08161.12 EDK35960.2 - 0.0011 18.7 0.8 0.44 10.2 0.0 3.5 2 1 1 3 3 3 1 NUC173 domain Cnd1 PF12717.7 EDK35960.2 - 0.0014 18.7 10.1 5.5 7.0 0.1 5.6 4 2 2 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDK35960.2 - 0.0016 17.1 8.9 0.23 10.0 1.8 4.0 3 1 1 4 4 4 2 Adaptin N terminal region CAF-1_p150 PF11600.8 EDK35960.2 - 0.011 15.5 9.7 0.024 14.3 9.7 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Elong_Iki1 PF10483.9 EDK35961.2 - 2.8e-71 240.5 2.2 3.3e-71 240.2 2.2 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 DDE_3 PF13358.6 EDK35961.2 - 0.0022 17.8 0.1 0.28 10.9 0.0 2.4 2 0 0 2 2 2 2 DDE superfamily endonuclease DUF3419 PF11899.8 EDK35961.2 - 0.0054 16.0 0.0 0.0084 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) KTI12 PF08433.10 EDK35961.2 - 0.016 14.6 0.8 0.025 14.0 0.8 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 MPM1 PF17234.2 EDK35962.2 - 0.00011 22.5 1.2 0.01 16.1 0.2 2.2 1 1 1 2 2 2 2 Mitochondrial peculiar membrane protein 1 Gpi16 PF04113.14 EDK35963.2 - 1e-209 697.7 0.0 1.2e-209 697.5 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Mad3_BUB1_I PF08311.12 EDK35964.2 - 3.4e-43 146.6 1.1 8.8e-43 145.2 1.1 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EDK35964.2 - 6.8e-16 58.4 0.0 1.3e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.11 EDK35964.2 - 2.1e-07 31.0 4.0 6e-07 29.5 0.2 3.0 3 0 0 3 3 3 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.17 EDK35964.2 - 4e-07 29.6 0.0 7.3e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EDK35964.2 - 7.6e-07 29.3 0.4 1.9e-06 28.0 0.4 1.6 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Kdo PF06293.14 EDK35964.2 - 0.077 12.3 0.1 0.24 10.7 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Homeobox_KN PF05920.11 EDK35964.2 - 0.096 12.6 0.0 6.5 6.7 0.0 2.8 2 0 0 2 2 2 0 Homeobox KN domain EF-hand_14 PF17959.1 EDK35964.2 - 0.16 12.3 0.2 0.95 9.9 0.0 2.4 3 0 0 3 3 3 0 EF-hand domain Pex14_N PF04695.13 EDK35965.2 - 3.7e-34 118.7 5.8 3.7e-34 118.7 5.8 3.4 2 2 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC84 PF14968.6 EDK35965.2 - 0.0015 18.3 7.3 0.0024 17.6 7.3 1.3 1 0 0 1 1 1 1 Coiled coil protein 84 Sipho_Gp157 PF05565.11 EDK35965.2 - 0.0018 18.3 7.1 0.0046 17.0 7.1 1.7 1 0 0 1 1 1 1 Siphovirus Gp157 Tup_N PF08581.10 EDK35965.2 - 0.044 14.1 6.9 0.055 13.8 4.4 2.2 1 1 1 2 2 2 0 Tup N-terminal F_actin_bind PF08919.10 EDK35965.2 - 0.059 13.5 2.2 0.35 11.0 0.1 2.7 1 1 0 2 2 2 0 F-actin binding SlyX PF04102.12 EDK35965.2 - 1.1 10.0 6.2 7.9 7.2 0.1 3.8 4 1 0 4 4 4 0 SlyX DUF948 PF06103.11 EDK35965.2 - 1.3 9.3 3.2 4.1 7.7 2.0 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Med5 PF08689.10 EDK35967.2 - 1.1e-72 245.4 34.9 1.5e-72 244.9 34.9 1.1 1 0 0 1 1 1 1 Mediator complex subunit Med5 dCache_3 PF14827.6 EDK35967.2 - 0.016 14.9 0.4 0.13 11.9 0.1 2.2 2 0 0 2 2 2 0 Double sensory domain of two-component sensor kinase CCM2_C PF16545.5 EDK35967.2 - 0.13 12.8 1.2 1.2 9.7 0.2 2.9 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology DNA_pol_B PF00136.21 EDK35969.2 - 3.3e-151 504.1 3.9 4.6e-151 503.6 3.9 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDK35969.2 - 5.5e-85 285.5 0.8 9e-85 284.8 0.8 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDK35969.2 - 2.9e-18 66.1 6.3 8.5e-18 64.6 6.3 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 EDK35969.2 - 0.002 17.9 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_2 PF03175.13 EDK35969.2 - 0.0045 15.9 3.9 0.024 13.5 0.2 2.9 3 1 0 3 3 3 1 DNA polymerase type B, organellar and viral DNA_pol_A_exo1 PF01612.20 EDK35969.2 - 0.049 13.3 0.1 0.13 11.9 0.1 1.8 1 0 0 1 1 1 0 3'-5' exonuclease DZR PF12773.7 EDK35969.2 - 2.4 8.3 8.7 0.091 12.8 1.1 2.2 2 0 0 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 EDK35969.2 - 2.4 8.1 8.4 6.5 6.7 1.2 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HATPase_c PF02518.26 EDK35970.2 - 9.3e-30 103.4 0.2 2e-29 102.4 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDK35970.2 - 6.3e-26 90.7 0.1 1.8e-25 89.2 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EDK35970.2 - 4.3e-18 65.1 3.0 1.3e-17 63.5 0.7 2.8 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EDK35971.1 - 4.2e-32 110.3 10.8 1.8e-09 37.8 1.1 5.8 6 0 0 6 6 6 4 HAMP domain DUF3829 PF12889.7 EDK35971.1 - 0.00028 20.5 5.3 0.13 11.8 0.5 3.9 3 1 0 3 3 3 1 Protein of unknown function (DUF3829) DUF1843 PF08898.10 EDK35971.1 - 0.00058 20.3 2.6 4.5 7.9 0.0 4.5 4 0 0 4 4 4 1 Domain of unknown function (DUF1843) DUF4279 PF14106.6 EDK35971.1 - 0.0006 20.0 0.5 1.6 9.0 0.0 4.4 4 2 1 5 5 5 1 Domain of unknown function (DUF4279) IL32 PF15225.6 EDK35971.1 - 0.0019 18.5 0.2 19 5.7 0.0 4.2 4 0 0 4 4 4 0 Interleukin 32 Myb_DNA-bind_5 PF13873.6 EDK35971.1 - 0.015 15.3 3.6 18 5.5 0.0 4.4 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain CMD PF02627.20 EDK35971.1 - 0.023 14.7 1.3 0.93 9.6 0.0 3.5 4 0 0 4 4 4 0 Carboxymuconolactone decarboxylase family DASH_Dad2 PF08654.10 EDK35971.1 - 0.054 13.9 0.6 0.054 13.9 0.6 5.4 2 1 1 5 5 5 0 DASH complex subunit Dad2 Terpene_synth_C PF03936.16 EDK35971.1 - 0.076 12.3 0.2 0.27 10.6 0.2 1.9 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain FYRC PF05965.14 EDK35971.1 - 0.095 12.9 1.1 18 5.6 0.0 3.8 4 0 0 4 4 3 0 F/Y rich C-terminus PseudoU_synth_1 PF01416.20 EDK35971.1 - 0.11 13.0 4.3 58 4.2 0.0 4.5 5 0 0 5 5 5 0 tRNA pseudouridine synthase LytTR PF04397.15 EDK35971.1 - 0.11 12.7 1.3 17 5.7 0.0 3.9 5 0 0 5 5 4 0 LytTr DNA-binding domain CENP-F_leu_zip PF10473.9 EDK35971.1 - 0.16 12.0 8.6 1.8 8.6 0.1 4.9 4 1 1 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SAM_Ste50p PF09235.10 EDK35971.1 - 0.3 11.4 4.3 29 5.0 0.0 4.1 4 1 0 4 4 4 0 Ste50p, sterile alpha motif BORCS6 PF10157.9 EDK35971.1 - 9.8 6.4 16.8 3.5 7.8 0.4 4.7 2 2 1 4 4 4 0 BLOC-1-related complex sub-unit 6 adh_short_C2 PF13561.6 EDK35973.1 - 2.2e-45 155.0 0.3 2.6e-45 154.8 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK35973.1 - 4.6e-38 130.6 1.1 6.1e-38 130.3 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK35973.1 - 6.6e-11 42.4 0.6 8.9e-11 42.0 0.6 1.1 1 0 0 1 1 1 1 KR domain PALP PF00291.25 EDK35973.1 - 0.0011 18.4 0.3 0.0019 17.7 0.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PDZ PF00595.24 EDK35973.1 - 0.052 13.9 0.6 0.11 12.9 0.6 1.5 1 0 0 1 1 1 0 PDZ domain Epimerase PF01370.21 EDK35973.1 - 0.072 12.5 0.2 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_C14 PF00656.22 EDK35974.2 - 7.3e-65 219.4 0.1 9.3e-65 219.0 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EDK35974.2 - 0.081 12.9 0.0 0.62 10.0 0.0 2.2 2 1 1 3 3 3 0 Raptor N-terminal CASPase like domain DUF1977 PF09320.11 EDK35975.2 - 1.8e-31 108.5 4.1 3.9e-31 107.4 4.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EDK35975.2 - 1.3e-23 82.9 1.1 1.3e-23 82.9 1.1 1.8 2 0 0 2 2 2 1 DnaJ domain Mito_carr PF00153.27 EDK35976.2 - 2.4e-46 155.6 1.3 8.3e-15 54.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.21 EDK35977.2 - 1.1e-26 92.3 7.2 3.5e-07 29.8 0.5 5.7 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat SAPS PF04499.15 EDK35978.1 - 0.7 8.6 14.4 0.93 8.2 14.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 EDK35978.1 - 2.7 7.3 41.6 3.6 6.8 41.6 1.1 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 EDK35978.1 - 4.6 5.7 28.3 6.5 5.2 28.3 1.2 1 0 0 1 1 1 0 Macoilin family Herpes_LMP1 PF05297.11 EDK35978.1 - 5.8 6.0 15.6 6.9 5.8 15.6 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RRN3 PF05327.11 EDK35979.2 - 7.5 5.0 12.5 9.1 4.7 12.5 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TetM_leader PF08076.11 EDK35980.2 - 0.13 12.1 0.3 0.56 10.0 0.0 2.1 2 0 0 2 2 2 0 Tetracycline resistance determinant leader peptide ACPS PF01648.20 EDK35981.2 - 1.9e-08 34.4 0.0 4.6e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily RNA_pol_Rpb1_3 PF04983.18 EDK35981.2 - 0.0017 18.3 0.1 0.11 12.4 0.0 2.3 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 3 Beta_elim_lyase PF01212.21 EDK35982.2 - 4e-79 266.0 0.0 4.8e-79 265.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDK35982.2 - 0.00018 20.8 0.0 0.00048 19.4 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Aldedh PF00171.22 EDK35983.1 - 1.4e-180 600.8 0.3 1.5e-180 600.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RNase_H PF00075.24 EDK35984.2 - 7.4e-32 110.5 0.5 2.6e-31 108.7 0.5 1.9 1 1 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EDK35984.2 - 1.3e-18 67.0 5.0 2.4e-18 66.2 5.0 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin T3SS_needle_E PF08988.10 EDK35984.2 - 0.038 14.1 0.0 0.098 12.8 0.0 1.7 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle RNase_H PF00075.24 EDK35985.2 - 2e-28 99.4 1.1 3.6e-28 98.5 1.1 1.4 1 1 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EDK35985.2 - 2.9e-13 49.9 1.3 5.9e-13 48.9 1.3 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.24 EDK35986.2 - 3.7e-23 82.3 0.0 5.9e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EDK35986.2 - 7.1e-14 51.8 1.1 1.4e-13 50.9 1.1 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin MFS_1 PF07690.16 EDK35987.2 - 1.9e-32 112.6 48.5 2.2e-32 112.4 47.3 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_1 PF00561.20 EDK35988.2 - 7.5e-34 117.5 0.0 1e-33 117.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK35988.2 - 1.4e-14 55.3 0.0 1.7e-14 55.0 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK35988.2 - 1.7e-09 37.3 0.0 3.4e-08 33.1 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 EDK35988.2 - 0.00022 20.9 0.0 0.046 13.4 0.0 2.4 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Ndr PF03096.14 EDK35988.2 - 0.0043 15.8 0.0 0.0058 15.4 0.0 1.2 1 0 0 1 1 1 1 Ndr family EHN PF06441.12 EDK35988.2 - 0.019 15.3 0.9 1.5 9.2 0.0 2.7 3 1 0 3 3 3 0 Epoxide hydrolase N terminus Phage_portal_2 PF05136.13 EDK35988.2 - 0.071 12.3 0.0 0.096 11.8 0.0 1.1 1 0 0 1 1 1 0 Phage portal protein, lambda family Chlorophyllase2 PF12740.7 EDK35988.2 - 0.083 11.8 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_5 PF12695.7 EDK35988.2 - 0.09 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PapC_C PF13953.6 EDK35988.2 - 0.15 11.9 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 PapC C-terminal domain zf-C2H2 PF00096.26 EDK35989.2 - 8.8e-16 57.4 24.5 0.00021 21.6 0.3 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK35989.2 - 8.9e-14 51.2 23.8 2e-05 24.8 1.0 5.0 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK35989.2 - 2.1e-10 40.5 24.0 0.00041 20.9 0.8 5.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK35989.2 - 1.4e-06 28.4 12.5 4.2e-05 23.7 0.4 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDK35989.2 - 0.0031 17.5 1.0 0.0031 17.5 1.0 3.7 5 0 0 5 5 5 1 C2H2-type zinc finger zf-met PF12874.7 EDK35989.2 - 0.012 16.0 1.2 0.012 16.0 1.2 4.9 4 1 1 5 5 5 0 Zinc-finger of C2H2 type IBR PF01485.21 EDK35989.2 - 0.048 13.9 1.4 0.048 13.9 1.4 3.2 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain zf-C2H2_8 PF15909.5 EDK35989.2 - 0.17 12.2 12.6 0.42 10.9 2.2 3.1 1 1 2 4 4 4 0 C2H2-type zinc ribbon zf-DNA_Pol PF08996.10 EDK35989.2 - 0.25 11.1 7.6 1.3 8.7 0.4 2.9 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zf-C2H2_3rep PF18868.1 EDK35989.2 - 0.31 11.7 6.9 4.8 7.9 0.1 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats CLP1_P PF16575.5 EDK35990.2 - 4.9e-53 179.7 0.0 7.9e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 EDK35990.2 - 0.0048 17.0 0.0 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EDK35990.2 - 0.022 14.5 0.1 0.048 13.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Nit_Regul_Hom PF10126.9 EDK35990.2 - 0.023 14.7 0.2 3.2 7.8 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII AAA_14 PF13173.6 EDK35990.2 - 0.055 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK35990.2 - 0.1 11.9 0.1 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATPase_2 PF01637.18 EDK35990.2 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea SMC_N PF02463.19 EDK35990.2 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EDK35990.2 - 0.15 12.0 0.1 0.35 10.8 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase Lectin_leg-like PF03388.13 EDK35991.2 - 3.2e-17 62.6 0.7 5e-17 62.0 0.7 1.2 1 0 0 1 1 1 1 Legume-like lectin family DUF2730 PF10805.8 EDK35991.2 - 0.0038 17.3 2.0 1.2 9.3 0.2 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF2730) LMBR1 PF04791.16 EDK35991.2 - 0.026 13.4 1.8 0.036 13.0 1.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-K PF11802.8 EDK35991.2 - 0.05 13.2 6.9 0.081 12.5 6.9 1.3 1 0 0 1 1 1 0 Centromere-associated protein K BLOC1_2 PF10046.9 EDK35991.2 - 0.15 12.4 7.8 2.4 8.5 1.2 3.3 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF848 PF05852.11 EDK35991.2 - 0.26 11.4 3.9 0.28 11.3 0.8 2.4 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Spc7 PF08317.11 EDK35991.2 - 1.1 8.0 10.1 1.8 7.4 10.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF745 PF05335.13 EDK35991.2 - 3.1 7.5 10.2 5.4 6.7 10.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Fzo_mitofusin PF04799.13 EDK35991.2 - 5.6 6.5 6.8 1.6 8.2 2.1 2.0 1 1 1 2 2 2 0 fzo-like conserved region Exonuc_VII_L PF02601.15 EDK35991.2 - 5.7 6.4 8.9 8.8 5.8 8.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RhoGAP PF00620.27 EDK35992.2 - 4.1e-15 55.9 0.2 1.5e-14 54.1 0.2 2.0 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 EDK35992.2 - 5.7e-15 55.1 0.0 1.4e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EDK35992.2 - 4.3e-07 30.1 6.1 2.7e-06 27.6 0.0 3.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Nod1 PF17114.5 EDK35992.2 - 0.01 16.0 0.2 0.052 13.7 0.1 2.4 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 DASH_Dam1 PF08653.10 EDK35992.2 - 0.29 11.0 3.8 20 5.1 0.1 3.7 4 0 0 4 4 4 0 DASH complex subunit Dam1 Arf PF00025.21 EDK35994.1 - 1.5e-79 265.5 0.1 1.7e-79 265.3 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDK35994.1 - 1.3e-14 54.4 0.0 1.7e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDK35994.1 - 2.7e-14 53.0 0.0 3.3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDK35994.1 - 3.3e-13 49.5 0.0 3.5e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDK35994.1 - 2.9e-12 46.4 0.9 1.4e-08 34.3 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDK35994.1 - 1.5e-10 40.8 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK35994.1 - 4.6e-06 26.7 0.0 7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDK35994.1 - 0.0049 16.2 0.4 0.0097 15.2 0.4 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase ECH_1 PF00378.20 EDK35995.1 - 4.4e-17 62.2 0.0 5.7e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDK35995.1 - 2e-09 37.4 0.0 2.6e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NPR3 PF03666.13 EDK35996.2 - 2.8e-131 438.5 5.2 4.2e-112 375.3 1.9 4.0 2 2 2 4 4 4 2 Nitrogen Permease regulator of amino acid transport activity 3 PRP8_domainIV PF12134.8 EDK35997.2 - 4.3e-124 412.6 0.5 8e-124 411.7 0.5 1.5 1 0 0 1 1 1 1 PRP8 domain IV core PROCN PF08083.11 EDK35997.2 - 3.1e-117 391.7 4.0 4.8e-117 391.1 4.0 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain U6-snRNA_bdg PF10596.9 EDK35997.2 - 4.5e-85 283.4 1.6 1e-84 282.3 1.6 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 EDK35997.2 - 2.2e-73 244.7 0.1 5.1e-73 243.5 0.1 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EDK35997.2 - 1.1e-46 157.1 0.2 3.7e-46 155.4 0.2 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EDK35997.2 - 1.1e-43 148.1 0.0 2.8e-43 146.7 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 EDK35997.2 - 0.033 14.1 0.0 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRO8NT PF08082.11 EDK35998.1 - 4.4e-76 254.0 2.2 7.9e-76 253.2 2.2 1.4 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain PROCN PF08083.11 EDK35998.1 - 4.5e-72 243.0 1.3 8e-72 242.2 1.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain zf-C3HC4_3 PF13920.6 EDK35999.2 - 7.8e-07 28.9 12.1 1.4e-06 28.1 12.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BatA PF07584.11 EDK35999.2 - 0.017 15.4 0.2 0.017 15.4 0.2 2.0 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal Aminotran_1_2 PF00155.21 EDK36000.2 - 7.8e-39 133.9 0.0 8.9e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4093 PF13331.6 EDK36000.2 - 0.17 12.4 0.0 19 5.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4093) TPR_1 PF00515.28 EDK36001.2 - 4.5e-26 89.5 18.9 1e-06 28.3 0.3 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat ANAPC8 PF04049.13 EDK36001.2 - 9.2e-24 84.1 10.1 1.7e-23 83.2 2.2 3.1 3 1 0 3 3 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 EDK36001.2 - 1.9e-19 68.1 21.8 1.3e-05 24.9 0.2 8.6 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 EDK36001.2 - 4.5e-19 67.0 20.6 3.9e-06 26.6 0.2 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDK36001.2 - 7.4e-15 54.4 5.6 0.00017 22.1 0.0 8.0 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36001.2 - 1.4e-14 54.4 2.2 1.1e-06 29.2 0.0 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDK36001.2 - 1.1e-11 44.2 8.6 2.9e-07 30.1 0.0 5.0 3 2 2 5 5 4 3 TPR repeat TPR_12 PF13424.6 EDK36001.2 - 5.8e-08 32.9 19.9 0.0057 16.9 0.0 7.0 6 2 0 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36001.2 - 1.2e-07 32.2 5.3 1 9.9 0.0 6.9 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDK36001.2 - 1.4e-07 31.0 2.3 1.3 9.2 0.0 6.4 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK36001.2 - 1.3e-06 28.3 9.5 0.12 12.8 0.0 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat ChAPs PF09295.10 EDK36001.2 - 2.1e-06 27.0 0.2 0.0069 15.4 0.0 3.7 3 1 1 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 EDK36001.2 - 4.9e-06 26.7 22.6 0.44 10.8 0.3 5.3 3 2 2 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDK36001.2 - 2.7e-05 24.2 0.0 0.26 11.4 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDK36001.2 - 0.035 14.7 11.5 12 6.8 0.0 6.5 9 0 0 9 9 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDK36001.2 - 0.19 11.2 0.8 1.1 8.8 0.4 2.5 2 0 0 2 2 2 0 SHNi-TPR Sel1 PF08238.12 EDK36001.2 - 0.26 12.0 1.8 42 5.0 0.3 3.4 2 0 0 2 2 2 0 Sel1 repeat DUF3856 PF12968.7 EDK36001.2 - 0.6 10.2 5.1 1.6 8.8 0.7 3.3 3 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 EDK36001.2 - 1.2 9.1 12.1 51 3.9 0.0 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 EDK36001.2 - 7.3 6.7 12.3 3.7 7.7 0.3 4.7 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain MPC PF03650.13 EDK36002.1 - 1.6e-45 153.7 0.0 1.8e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers ABC_membrane PF00664.23 EDK36003.2 - 6.3e-66 222.8 41.9 1.7e-39 136.1 14.5 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK36003.2 - 5.9e-49 166.1 0.0 2.2e-29 102.7 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK36003.2 - 9.4e-13 48.1 8.0 4.6e-05 23.0 1.6 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDK36003.2 - 7.7e-06 26.0 0.6 0.12 12.4 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDK36003.2 - 7.2e-05 22.4 0.1 0.52 10.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK36003.2 - 0.00014 22.3 0.0 0.053 13.9 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EDK36003.2 - 0.00052 20.1 3.6 0.02 15.0 0.4 2.6 2 0 0 2 2 2 1 Dynamin family AAA_15 PF13175.6 EDK36003.2 - 0.00092 19.0 0.1 0.083 12.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDK36003.2 - 0.0014 18.6 0.1 2.6 7.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EDK36003.2 - 0.0038 17.1 6.2 0.62 9.8 1.1 4.2 2 2 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDK36003.2 - 0.0045 17.5 0.9 0.98 9.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDK36003.2 - 0.0052 17.1 1.6 6.7 7.0 0.0 4.0 3 1 0 3 3 3 1 AAA domain DUF87 PF01935.17 EDK36003.2 - 0.0054 16.9 0.2 0.89 9.6 0.0 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain T2SSE PF00437.20 EDK36003.2 - 0.0061 15.7 0.0 3.9 6.5 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_24 PF13479.6 EDK36003.2 - 0.036 13.8 0.1 10 5.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDK36003.2 - 0.04 13.6 0.1 4.2 7.1 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein NB-ARC PF00931.22 EDK36003.2 - 0.041 13.1 0.1 9.3 5.3 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.26 EDK36003.2 - 0.12 12.0 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain SbcCD_C PF13558.6 EDK36003.2 - 0.15 12.3 0.1 9.4 6.6 0.1 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EDK36003.2 - 0.19 11.4 1.1 18 5.0 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AIG1 PF04548.16 EDK36003.2 - 1.3 8.3 3.9 9.4 5.5 0.7 2.5 2 0 0 2 2 2 0 AIG1 family Aconitase PF00330.20 EDK36004.1 - 7.2e-154 513.2 0.0 8.9e-154 512.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDK36004.1 - 3.2e-44 150.4 0.0 5.7e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Zn_clus PF00172.18 EDK36006.2 - 6.6e-09 35.8 6.8 1.5e-08 34.6 6.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK36006.2 - 3e-05 23.2 0.3 3e-05 23.2 0.3 3.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain FAM163 PF15069.6 EDK36006.2 - 8 6.9 9.6 0.23 11.9 2.6 2.0 2 1 0 2 2 2 0 FAM163 family Sec23_trunk PF04811.15 EDK36007.2 - 5e-72 242.4 0.0 7.4e-72 241.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDK36007.2 - 3e-34 117.6 0.1 6e-34 116.7 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDK36007.2 - 2.4e-23 81.9 0.1 5.3e-23 80.8 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EDK36007.2 - 5.4e-13 48.6 0.0 1.2e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EDK36007.2 - 6.3e-11 42.1 7.3 1.3e-10 41.1 7.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger ThiF PF00899.21 EDK36008.2 - 1.4e-19 70.5 0.0 1.9e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family Phage_portal PF04860.12 EDK36008.2 - 0.015 14.6 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 Phage portal protein HDA2-3 PF11496.8 EDK36009.2 - 3.1e-103 345.0 0.1 3.1e-103 345.0 0.1 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Cep57_CLD_2 PF14197.6 EDK36009.2 - 0.026 14.6 26.1 0.92 9.6 6.9 3.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 YabA PF06156.13 EDK36009.2 - 0.58 10.8 21.1 4.8 7.9 6.1 2.7 1 1 1 2 2 2 0 Initiation control protein YabA BORCS8 PF10167.9 EDK36009.2 - 0.63 10.0 14.7 0.099 12.6 6.0 2.6 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 8 CENP-F_leu_zip PF10473.9 EDK36009.2 - 0.75 9.8 35.6 0.7 9.9 20.7 2.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EDK36009.2 - 1 9.8 18.2 0.06 13.8 2.7 3.3 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EDK36009.2 - 1.9 7.8 35.4 0.95 8.8 14.1 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 EDK36009.2 - 2 7.2 35.0 11 4.8 35.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) PRKG1_interact PF15898.5 EDK36009.2 - 3.5 8.6 31.6 0.58 11.1 2.9 3.4 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Speriolin_C PF15059.6 EDK36009.2 - 8.6 6.5 9.9 0.33 11.1 2.2 2.6 2 2 1 3 3 3 0 Speriolin C-terminus WD40 PF00400.32 EDK36010.2 - 1.2e-36 124.0 23.2 3.7e-09 37.0 0.3 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36010.2 - 1.9e-11 44.1 0.1 0.0012 19.1 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 EDK36010.2 - 8.1e-10 38.1 1.5 1.4e-09 37.4 1.5 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 EDK36010.2 - 3.4e-05 23.0 0.5 0.19 10.6 0.1 3.5 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EDK36010.2 - 0.017 14.5 0.1 1 8.6 0.0 2.8 2 1 0 3 3 3 0 WD40-like domain Peptidase_M16 PF00675.20 EDK36011.2 - 1.5e-25 89.9 0.0 3.9e-25 88.6 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 EDK36011.2 - 7.3e-10 38.6 0.1 1.3e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 EDK36011.2 - 4.5e-07 30.1 0.5 0.022 14.8 0.0 3.7 3 1 0 3 3 3 2 Peptidase M16 inactive domain TrmK PF04816.12 EDK36011.2 - 0.11 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase DUF4452 PF14618.6 EDK36012.2 - 0.00042 20.2 21.3 0.0013 18.6 2.7 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF4452) Cu_amine_oxid PF01179.20 EDK36013.2 - 9.8e-158 525.4 0.3 1.2e-157 525.1 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EDK36013.2 - 0.0047 17.1 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain SRP1_TIP1 PF00660.17 EDK36014.2 - 1.8e-22 79.3 0.5 2.4e-22 78.9 0.5 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family LRR_8 PF13855.6 EDK36016.2 - 6.9e-15 54.6 20.1 4.6e-11 42.3 2.6 3.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EDK36016.2 - 2.2e-14 53.3 28.0 8.8e-07 29.2 9.2 4.5 3 2 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EDK36016.2 - 1.3e-05 24.8 11.6 1.4e-05 24.7 6.8 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.6 EDK36016.2 - 0.00087 19.3 0.2 0.0027 17.7 0.2 1.9 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EDK36016.2 - 0.019 14.9 2.8 0.019 14.9 2.8 4.4 5 0 0 5 5 5 0 Leucine Rich repeat Glyco_hydro_3 PF00933.21 EDK36017.1 - 6e-28 98.1 0.0 1.3e-27 97.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EDK36019.2 - 6.7e-48 163.3 0.0 9.5e-48 162.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EDK36019.2 - 2.3e-23 82.1 0.0 4.5e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain MFS_1 PF07690.16 EDK36020.2 - 1e-48 166.1 38.9 3.2e-47 161.2 39.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK36020.2 - 4.8e-17 61.6 22.3 8.7e-17 60.8 22.3 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK36020.2 - 4.3e-12 45.6 8.2 4.3e-12 45.6 8.2 2.8 2 1 0 3 3 3 1 Sugar (and other) transporter DUF4407 PF14362.6 EDK36021.2 - 0.025 13.9 14.2 0.0097 15.3 8.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1542 PF07564.11 EDK36021.2 - 0.12 12.5 6.7 0.083 13.0 3.5 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF99 PF01949.16 EDK36021.2 - 2.1 7.7 5.2 0.97 8.8 1.5 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF99 Baculo_PEP_C PF04513.12 EDK36021.2 - 2.6 8.1 9.9 1.7 8.7 0.8 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DNA_pol_E_B PF04042.16 EDK36022.2 - 8e-40 136.4 0.2 1.7e-39 135.4 0.1 1.7 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EDK36022.2 - 0.064 13.4 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain Prenyltrans PF00432.21 EDK36023.2 - 9e-60 198.1 0.9 5.9e-13 48.3 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EDK36023.2 - 7.4e-08 31.9 0.0 1.1e-05 24.7 0.0 3.3 1 1 2 3 3 3 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDK36023.2 - 0.0098 15.0 0.0 0.63 9.1 0.0 3.2 2 1 2 4 4 4 1 Squalene-hopene cyclase N-terminal domain Myb_DNA-binding PF00249.31 EDK36024.2 - 6e-12 45.6 0.6 8.9e-12 45.0 0.6 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK36024.2 - 9.7e-12 45.0 0.2 1.6e-11 44.3 0.2 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA PF00004.29 EDK36025.2 - 3.4e-39 134.3 0.0 8.3e-39 133.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDK36025.2 - 6e-08 32.6 1.3 4.5e-06 26.6 0.0 3.7 4 0 0 4 4 3 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 EDK36025.2 - 6e-05 22.8 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDK36025.2 - 0.00017 21.9 1.6 0.0032 17.7 0.4 2.9 2 1 0 2 2 1 1 AAA domain AAA_2 PF07724.14 EDK36025.2 - 0.00018 21.7 0.0 0.0004 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EDK36025.2 - 0.00051 19.3 0.0 0.00085 18.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EDK36025.2 - 0.00062 20.2 0.5 0.0027 18.1 0.1 2.2 2 1 0 2 2 1 1 AAA ATPase domain AAA_lid_3 PF17862.1 EDK36025.2 - 0.00071 19.3 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDK36025.2 - 0.00087 19.3 0.1 0.004 17.1 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDK36025.2 - 0.0045 16.4 0.1 0.0088 15.4 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDK36025.2 - 0.0079 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.6 EDK36025.2 - 0.0088 15.6 0.0 0.07 12.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDK36025.2 - 0.011 15.9 0.0 0.023 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EDK36025.2 - 0.012 14.8 0.0 0.054 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 EDK36025.2 - 0.021 14.9 0.0 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDK36025.2 - 0.033 13.6 0.0 3.4 7.1 0.0 2.5 1 1 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 EDK36025.2 - 0.045 14.3 0.0 0.14 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDK36025.2 - 0.048 13.6 0.1 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 EDK36025.2 - 0.054 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDK36025.2 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 EDK36025.2 - 0.082 12.2 0.0 1.3 8.3 0.0 2.4 1 1 1 2 2 2 0 KaiC RNA_helicase PF00910.22 EDK36025.2 - 0.12 12.8 0.1 0.64 10.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Peptidase_M3_N PF08439.10 EDK36025.2 - 0.12 12.6 0.1 0.9 9.9 0.0 2.4 2 0 0 2 2 2 0 Oligopeptidase F PhoH PF02562.16 EDK36025.2 - 0.16 11.4 0.0 0.41 10.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 EDK36025.2 - 0.18 11.5 0.0 0.42 10.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MFS_1 PF07690.16 EDK36026.2 - 3.7e-43 147.8 52.3 7.5e-33 113.9 30.1 3.3 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK36026.2 - 3.7e-12 45.5 15.6 5.6e-12 44.9 15.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK36026.2 - 5.4e-11 42.0 6.8 5.4e-11 42.0 6.8 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter DnaJ-X PF14308.6 EDK36027.2 - 9.7e-65 217.9 10.7 9.7e-65 217.9 10.7 1.8 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDK36027.2 - 2.5e-23 82.0 0.3 2.5e-23 82.0 0.3 2.6 4 0 0 4 4 4 1 DnaJ domain UDPGT PF00201.18 EDK36027.2 - 0.19 10.5 2.8 0.26 10.0 2.8 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Complex1_LYR PF05347.15 EDK36028.1 - 1.7e-15 56.8 0.1 2.1e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDK36028.1 - 0.00077 20.2 0.2 0.0009 19.9 0.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EDK36028.1 - 0.063 13.9 0.1 0.068 13.8 0.1 1.1 1 0 0 1 1 1 0 Complex1_LYR-like adh_short PF00106.25 EDK36029.1 - 5.6e-32 110.8 0.0 3.4e-31 108.2 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK36029.1 - 7.1e-29 101.0 0.0 8.4e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK36029.1 - 5.6e-09 36.2 0.0 7.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK36029.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK36029.1 - 0.00015 21.3 0.1 0.00043 19.8 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family STALD PF18185.1 EDK36029.1 - 0.046 13.0 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family DUF4868 PF16162.5 EDK36029.1 - 0.051 13.5 0.1 0.1 12.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4868) DUF3866 PF12982.7 EDK36029.1 - 0.17 10.9 0.0 0.82 8.7 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3866) TRAPPC10 PF12584.8 EDK36030.2 - 1.7e-15 57.1 0.0 3.1e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF410 PF04190.13 EDK36030.2 - 0.023 14.5 0.4 2.9 7.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF410) TPR_12 PF13424.6 EDK36030.2 - 0.08 13.2 0.1 6.3 7.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Sugar_tr PF00083.24 EDK36031.1 - 9e-24 84.1 15.1 9.8e-23 80.7 15.1 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK36031.1 - 5.3e-20 71.6 12.7 6.1e-20 71.4 10.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK36032.1 - 6.1e-10 38.6 2.8 7.3e-10 38.3 2.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK36032.1 - 6.2e-10 38.5 0.2 7.8e-10 38.2 0.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Exo_endo_phos PF03372.23 EDK36033.2 - 2.5e-12 46.8 2.5 3.6e-12 46.3 2.5 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Calreticulin PF00262.18 EDK36034.2 - 2.5e-146 487.2 6.2 4e-146 486.6 6.2 1.3 1 0 0 1 1 1 1 Calreticulin family TssO PF17561.2 EDK36034.2 - 0.055 13.6 1.3 0.061 13.4 0.1 1.6 2 0 0 2 2 2 0 Type VI secretion system, TssO Alb1 PF09135.11 EDK36035.2 - 8.8e-12 45.8 7.2 8.8e-12 45.8 7.2 2.1 2 0 0 2 2 2 1 Alb1 CENP-B_dimeris PF09026.10 EDK36035.2 - 0.29 11.5 5.1 0.39 11.1 4.6 1.5 1 1 0 1 1 1 0 Centromere protein B dimerisation domain BSD PF03909.17 EDK36036.2 - 2.3e-22 78.7 2.5 5.1e-14 52.0 0.1 3.0 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 EDK36036.2 - 6.9e-17 61.6 0.1 1.7e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain Coa1 PF08695.10 EDK36037.2 - 2.6e-41 140.0 0.0 3.7e-41 139.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SKG6 PF08693.10 EDK36038.2 - 0.022 14.2 1.7 0.022 14.2 1.7 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain TMEM154 PF15102.6 EDK36038.2 - 0.023 14.6 0.9 0.045 13.7 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family YajC PF02699.15 EDK36038.2 - 0.078 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit EphA2_TM PF14575.6 EDK36038.2 - 0.093 13.6 0.0 0.19 12.6 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 EDK36038.2 - 0.094 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 FAM176 family Peptidase_M48 PF01435.18 EDK36039.2 - 6.1e-28 97.9 0.0 1.1e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 Yos9_DD PF17880.1 EDK36039.2 - 0.025 14.7 0.7 0.39 10.9 0.1 2.6 3 0 0 3 3 3 0 Yos9 dimerzation domain Zincin_1 PF06262.11 EDK36039.2 - 0.079 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Zincin-like metallopeptidase Minor_capsid_3 PF12691.7 EDK36040.2 - 0.045 14.1 0.5 0.52 10.7 0.0 2.4 2 1 0 2 2 2 0 Minor capsid protein from bacteriophage Kin17_mid PF10357.9 EDK36041.2 - 1.4e-38 131.6 5.5 1.4e-38 131.6 5.5 2.1 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 EDK36041.2 - 2.6e-05 24.4 6.9 2.6e-05 24.4 6.9 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDK36041.2 - 0.00015 22.0 4.9 0.00045 20.5 4.9 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDK36041.2 - 0.0048 17.2 1.0 0.0048 17.2 1.0 2.6 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 EDK36041.2 - 0.027 14.7 1.5 0.027 14.7 1.5 3.0 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) UCH PF00443.29 EDK36042.2 - 2.1e-50 171.6 0.6 3.3e-50 171.0 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK36042.2 - 2.8e-16 60.0 0.0 8.6e-16 58.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-BED PF02892.15 EDK36042.2 - 5e-05 23.2 0.8 0.024 14.7 0.2 2.9 2 0 0 2 2 2 2 BED zinc finger Rubredoxin_2 PF18073.1 EDK36042.2 - 0.53 10.0 4.4 6.1 6.7 0.4 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain Myb_DNA-bind_6 PF13921.6 EDK36043.2 - 3.2e-30 104.1 0.3 4.8e-11 42.7 0.0 3.7 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDK36043.2 - 6.1e-30 103.2 14.3 1.4e-12 47.6 0.1 3.7 4 0 0 4 4 4 3 Myb-like DNA-binding domain SLIDE PF09111.10 EDK36043.2 - 7.9e-06 25.9 0.2 1.1 9.3 0.0 4.4 3 1 1 4 4 4 1 SLIDE SANT_DAMP1_like PF16282.5 EDK36043.2 - 0.0015 18.6 2.0 0.075 13.2 0.2 3.3 2 1 1 3 3 3 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_4 PF13837.6 EDK36043.2 - 0.0029 18.0 6.6 0.079 13.3 0.0 3.8 2 1 1 3 3 3 1 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 EDK36043.2 - 0.046 13.8 0.4 0.96 9.6 0.3 2.7 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain THF_DHG_CYH PF00763.23 EDK36044.2 - 8e-27 93.8 0.0 1.5e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EDK36044.2 - 1.9e-19 69.5 0.1 3.4e-11 42.7 0.0 3.1 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.24 EDK36044.2 - 0.0049 17.3 0.0 0.0087 16.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RabGAP-TBC PF00566.18 EDK36045.2 - 9.3e-48 162.7 6.1 7.5e-47 159.8 6.1 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain HSP70 PF00012.20 EDK36046.2 - 1.1e-77 261.7 6.6 1.1e-77 261.7 6.6 1.6 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EDK36046.2 - 1.2e-08 34.2 0.4 1.8e-08 33.6 0.4 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Exo_endo_phos PF03372.23 EDK36047.2 - 1.1e-07 31.6 0.0 5.3e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Surp PF01805.20 EDK36048.2 - 0.0043 17.0 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 Surp module RAI1 PF08652.11 EDK36048.2 - 0.07 13.3 0.0 0.27 11.4 0.0 2.0 1 1 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease Maf PF02545.14 EDK36049.2 - 1.7e-39 135.4 0.0 2e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein His_Phos_1 PF00300.22 EDK36050.2 - 7.5e-19 68.2 0.0 1.2e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF572 PF04502.13 EDK36051.2 - 2e-56 192.0 15.9 2.5e-56 191.7 15.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Mut7-C PF01927.16 EDK36051.2 - 0.0095 16.0 0.4 0.0095 16.0 0.4 2.1 2 1 0 2 2 2 1 Mut7-C RNAse domain HOOK PF05622.12 EDK36051.2 - 0.018 13.2 18.0 0.025 12.8 18.0 1.1 1 0 0 1 1 1 0 HOOK protein zf_UBZ PF18439.1 EDK36051.2 - 0.022 14.3 2.0 3.6 7.3 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Nucleocap_ssRNA PF11128.8 EDK36051.2 - 0.028 14.1 0.2 0.12 12.1 0.0 2.0 1 1 1 2 2 2 0 Plant viral coat protein nucleocapsid FapA PF03961.13 EDK36051.2 - 0.082 11.5 10.6 0.047 12.3 8.4 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A HypA PF01155.19 EDK36051.2 - 0.1 12.6 0.2 0.25 11.4 0.2 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 EDK36051.2 - 0.72 9.8 4.6 17 5.4 0.5 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 EDK36051.2 - 2.8 7.9 5.3 8.5 6.4 0.3 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain Trypan_glycop PF00913.19 EDK36051.2 - 3 7.0 11.3 0.18 11.1 2.4 2.2 1 1 1 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) DUF883 PF05957.13 EDK36051.2 - 3.4 8.3 6.6 6.9 7.3 6.0 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) V_ATPase_I PF01496.19 EDK36051.2 - 3.8 5.3 12.8 5.9 4.7 12.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PA26 PF04636.13 EDK36051.2 - 9.4 5.0 8.8 13 4.6 8.8 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) 2-oxoacid_dh PF00198.23 EDK36052.2 - 1.2e-74 250.7 0.1 1.5e-74 250.3 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDK36052.2 - 1.1e-16 60.4 0.0 2.3e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDK36052.2 - 1.3e-13 51.0 0.3 3.5e-13 49.7 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain RNA_pol_Rpc4 PF05132.14 EDK36052.2 - 0.028 14.9 2.0 0.064 13.7 2.0 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Rep-A_N PF04057.12 EDK36052.2 - 0.073 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain Coilin_N PF15862.5 EDK36052.2 - 0.63 9.8 6.2 1.1 9.1 6.2 1.3 1 0 0 1 1 1 0 Coilin N-terminus SspB PF04386.13 EDK36052.2 - 3.7 7.4 5.4 6.4 6.6 5.4 1.3 1 0 0 1 1 1 0 Stringent starvation protein B RNase_HII PF01351.18 EDK36053.2 - 2.5e-52 177.6 0.0 3.2e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Mito_carr PF00153.27 EDK36054.2 - 2.4e-59 197.2 5.2 3.5e-20 71.7 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein YqcI_YcgG PF08892.11 EDK36054.2 - 0.06 13.2 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 YqcI/YcgG family MA3 PF02847.17 EDK36054.2 - 0.12 12.3 0.0 0.55 10.2 0.0 2.1 1 1 1 2 2 2 0 MA3 domain Lipid_DES PF08557.10 EDK36054.2 - 0.31 10.5 1.5 3.4 7.3 0.1 2.3 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) Syja_N PF02383.18 EDK36055.2 - 6.6e-75 252.4 0.3 2.2e-73 247.4 0.0 2.3 2 0 0 2 2 2 2 SacI homology domain Exo_endo_phos PF03372.23 EDK36055.2 - 4.5e-09 36.2 0.0 9.7e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.16 EDK36056.1 - 2e-30 104.6 0.9 3.5e-30 103.8 0.9 1.4 1 0 0 1 1 1 1 YEATS family Sec23_trunk PF04811.15 EDK36058.2 - 4.7e-50 170.4 0.1 2.1e-48 165.1 0.1 2.1 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDK36058.2 - 5e-33 113.7 0.0 1.2e-32 112.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDK36058.2 - 1.2e-23 82.9 0.1 2.9e-23 81.7 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 EDK36058.2 - 1.2e-08 34.8 0.0 2.6e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EDK36058.2 - 1.8e-08 34.3 2.3 4.5e-08 33.0 2.3 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger tRNA-synt_2 PF00152.20 EDK36059.2 - 4e-67 226.5 0.0 5.3e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDK36059.2 - 1.4e-08 34.6 0.0 2.5e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDK36059.2 - 8.6e-06 25.4 0.2 0.0028 17.2 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 EDK36059.2 - 0.13 12.5 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RhoGAP PF00620.27 EDK36060.2 - 8.3e-39 132.8 0.0 3.1e-38 131.0 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.19 EDK36060.2 - 3.1e-17 63.3 3.5 2.7e-15 57.0 0.1 3.1 2 1 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 EDK36060.2 - 2.2e-16 60.0 0.6 1.1e-15 57.8 0.6 2.3 1 0 0 1 1 1 1 RasGEF N-terminal motif PH_9 PF15410.6 EDK36060.2 - 0.0079 16.6 0.7 0.36 11.2 0.0 3.5 4 0 0 4 4 4 1 Pleckstrin homology domain PH PF00169.29 EDK36060.2 - 0.018 15.5 0.1 0.13 12.8 0.1 2.5 1 1 0 1 1 1 0 PH domain 60KD_IMP PF02096.20 EDK36061.2 - 5.3e-26 91.5 3.7 5.3e-26 91.5 3.7 1.4 2 0 0 2 2 2 1 60Kd inner membrane protein DUF4315 PF14193.6 EDK36061.2 - 0.84 9.7 4.2 4.4 7.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) TPR_6 PF13174.6 EDK36062.2 - 0.05 14.2 0.1 2.2 9.1 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 EDK36062.2 - 0.065 13.4 0.5 36 4.6 0.1 3.5 2 1 0 2 2 2 0 PPR repeat family DUF2977 PF11192.8 EDK36062.2 - 0.13 12.4 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2977) AAA_23 PF13476.6 EDK36063.2 - 3.2e-13 50.6 25.1 3.2e-13 50.6 25.1 5.4 2 2 1 3 3 1 1 AAA domain SMC_N PF02463.19 EDK36063.2 - 2.3e-12 46.9 50.8 1.1e-11 44.7 50.8 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EDK36063.2 - 3.3e-05 23.8 24.3 3.3e-05 23.8 24.3 5.1 1 1 2 4 4 4 1 AAA ATPase domain DUF745 PF05335.13 EDK36063.2 - 0.00028 20.7 6.8 0.00028 20.7 6.8 5.8 5 1 1 6 6 5 1 Protein of unknown function (DUF745) ADIP PF11559.8 EDK36063.2 - 0.00075 19.6 7.2 0.00075 19.6 7.2 6.9 3 2 4 7 7 6 2 Afadin- and alpha -actinin-Binding AAA_21 PF13304.6 EDK36063.2 - 0.00078 19.3 0.7 0.00078 19.3 0.7 4.5 3 2 1 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_13 PF13166.6 EDK36063.2 - 0.0011 17.8 76.6 0.0015 17.3 16.2 5.6 3 2 1 5 5 5 2 AAA domain Laminin_II PF06009.12 EDK36063.2 - 0.0024 17.9 60.7 0.56 10.2 8.4 7.2 4 2 2 7 7 7 4 Laminin Domain II TPR_MLP1_2 PF07926.12 EDK36063.2 - 0.01 15.9 14.3 0.01 15.9 14.3 7.4 3 2 2 6 6 5 0 TPR/MLP1/MLP2-like protein AAA_29 PF13555.6 EDK36063.2 - 0.011 15.5 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TMF_DNA_bd PF12329.8 EDK36063.2 - 0.011 15.7 3.1 0.011 15.7 3.1 7.6 4 2 6 10 10 9 0 TATA element modulatory factor 1 DNA binding SbcCD_C PF13558.6 EDK36063.2 - 0.013 15.7 0.0 0.061 13.6 0.0 2.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Surfac_D-trimer PF09006.11 EDK36063.2 - 0.017 15.0 0.0 17 5.4 0.0 4.6 5 0 0 5 5 4 0 Lung surfactant protein D coiled-coil trimerisation Ploopntkinase3 PF18751.1 EDK36063.2 - 0.07 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 ABC_tran PF00005.27 EDK36063.2 - 0.1 13.1 0.1 0.1 13.1 0.1 5.1 4 2 0 4 4 3 0 ABC transporter NACHT PF05729.12 EDK36063.2 - 0.29 11.0 2.7 5.4 6.9 0.2 2.8 2 0 0 2 2 2 0 NACHT domain Fez1 PF06818.15 EDK36063.2 - 0.39 11.1 71.9 0.21 12.0 4.9 5.1 3 2 2 5 5 5 0 Fez1 Fib_alpha PF08702.10 EDK36063.2 - 0.61 10.3 63.9 0.17 12.1 1.1 6.6 3 2 3 6 6 6 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 EDK36063.2 - 0.88 9.0 74.9 1.6 8.1 23.4 3.8 2 2 1 3 3 3 0 Golgin subfamily A member 5 FPP PF05911.11 EDK36063.2 - 3.1 5.9 69.2 1.2 7.2 19.0 3.4 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil DUF724 PF05266.14 EDK36063.2 - 6.5 6.5 73.1 1.4 8.7 8.1 6.2 3 2 3 6 6 6 0 Protein of unknown function (DUF724) Spc7 PF08317.11 EDK36063.2 - 9.7 5.0 77.7 0.41 9.5 16.7 5.9 2 2 2 4 4 4 0 Spc7 kinetochore protein NUP PF06516.11 EDK36064.2 - 1.4e-118 395.7 0.0 1.7e-118 395.5 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) NUP PF06516.11 EDK36065.2 - 3.3e-131 437.2 0.0 4.2e-131 436.8 0.0 1.1 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) Amidohydro_1 PF01979.20 EDK36066.2 - 2.3e-72 244.2 0.0 2.8e-72 243.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EDK36066.2 - 2.2e-08 34.0 0.0 1.7e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family CFEM PF05730.11 EDK36067.1 - 5.7e-10 39.1 13.1 5.7e-10 39.1 13.1 2.0 2 1 0 2 2 2 1 CFEM domain Plasmodium_Vir PF05795.11 EDK36067.1 - 0.89 8.9 11.4 1.1 8.6 11.4 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Utp14 PF04615.13 EDK36067.1 - 4 5.9 10.3 4.6 5.7 10.3 1.0 1 0 0 1 1 1 0 Utp14 protein DUF3712 PF12505.8 EDK36068.2 - 0.0049 17.1 9.6 0.052 13.8 1.3 4.1 5 0 0 5 5 5 2 Protein of unknown function (DUF3712) Rogdi_lz PF10259.9 EDK36070.2 - 1.4e-67 228.0 0.4 1.7e-67 227.7 0.4 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DHC_N1 PF08385.12 EDK36070.2 - 0.17 10.5 0.2 0.26 9.9 0.2 1.2 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 Aft1_HRA PF11786.8 EDK36070.2 - 0.21 11.9 3.0 0.16 12.3 0.7 2.0 2 0 0 2 2 2 0 Aft1 HRA domain RskA PF10099.9 EDK36071.2 - 0.0017 18.7 3.6 0.0017 18.7 3.6 1.8 2 0 0 2 2 2 1 Anti-sigma-K factor rskA DUF4524 PF15025.6 EDK36071.2 - 0.14 11.9 0.0 0.14 11.9 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4524) SAE2 PF08573.10 EDK36071.2 - 4.5 8.4 9.5 4 8.6 0.4 2.5 2 1 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Peptidase_M16_M PF16187.5 EDK36072.2 - 9.1e-84 281.0 1.2 1.7e-83 280.2 1.2 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EDK36072.2 - 2.2e-40 138.1 0.2 4.7e-40 137.0 0.2 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDK36072.2 - 4.9e-25 88.6 0.1 7.6e-17 61.9 0.0 2.4 2 0 0 2 2 2 2 Peptidase M16 inactive domain DUF4525 PF15027.6 EDK36072.2 - 0.11 12.2 0.0 0.42 10.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) Sec1 PF00995.23 EDK36073.2 - 1.2e-104 351.7 20.1 1.4e-104 351.5 20.1 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_C10 PF01640.17 EDK36073.2 - 0.18 12.1 1.0 0.93 9.8 0.1 2.5 2 1 1 3 3 3 0 Peptidase C10 family Syntaxin-18_N PF10496.9 EDK36073.2 - 0.33 11.2 3.8 0.24 11.7 0.8 2.5 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus Sod_Fe_C PF02777.18 EDK36074.2 - 6.3e-31 106.6 0.4 6.3e-31 106.6 0.4 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDK36074.2 - 3.6e-25 88.2 0.2 6.2e-25 87.5 0.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.7 EDK36074.2 - 0.066 13.3 0.0 0.55 10.4 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif MFS_1 PF07690.16 EDK36075.2 - 4.3e-20 71.9 51.4 4.1e-19 68.7 47.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF2976 PF11190.8 EDK36075.2 - 0.032 14.0 8.9 0.2 11.5 0.6 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2976) DUF3980 PF13140.6 EDK36075.2 - 8.1 7.0 9.1 25 5.4 0.2 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3980) PHD PF00628.29 EDK36076.2 - 4.6e-09 36.0 3.4 4.6e-09 36.0 3.4 1.8 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EDK36076.2 - 0.16 11.5 4.8 0.28 10.8 4.8 1.4 1 0 0 1 1 1 0 PHD-finger SOBP PF15279.6 EDK36076.2 - 2.4 8.7 9.0 3.5 8.1 9.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein CRAL_TRIO PF00650.20 EDK36077.2 - 6.3e-41 139.7 0.1 9.6e-41 139.1 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDK36077.2 - 2e-06 28.0 0.0 3.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK36077.2 - 0.0035 17.5 0.7 0.011 15.9 0.2 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Nup_retrotrp_bd PF10599.9 EDK36078.2 - 7.2e-17 61.8 8.5 7.2e-17 61.8 8.5 9.3 2 1 4 6 6 6 1 Retro-transposon transporting motif UPF0231 PF06062.11 EDK36078.2 - 0.019 15.2 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) AMP-binding PF00501.28 EDK36079.2 - 6.8e-46 156.7 0.0 2.7e-23 82.3 0.0 3.5 2 2 0 2 2 2 2 AMP-binding enzyme PPR_2 PF13041.6 EDK36080.2 - 2.2e-13 50.2 2.4 0.00055 20.1 0.0 4.3 4 2 2 6 6 6 3 PPR repeat family PPR_long PF17177.4 EDK36080.2 - 4.8e-13 49.0 0.3 8.4e-08 31.8 0.1 2.4 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EDK36080.2 - 5e-12 45.2 2.5 0.0017 18.5 0.0 4.9 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 EDK36080.2 - 6.7e-08 32.5 3.0 1.1e-05 25.4 0.1 3.7 2 1 2 4 4 4 2 Pentatricopeptide repeat domain ERAP1_C PF11838.8 EDK36080.2 - 0.00031 20.4 0.0 0.00063 19.4 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain ATP13 PF12921.7 EDK36080.2 - 0.0072 16.2 0.7 0.0072 16.2 0.7 2.8 2 1 0 2 2 2 1 Mitochondrial ATPase expression DUF928 PF06051.12 EDK36080.2 - 0.014 15.3 0.1 0.026 14.4 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) TPR_3 PF07720.12 EDK36080.2 - 0.056 13.5 0.2 51 4.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat tRNA-synt_1_2 PF13603.6 EDK36081.1 - 1.2e-45 155.3 0.0 2e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 EDK36081.1 - 3.4e-42 144.5 3.5 7.5e-33 113.7 0.7 5.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDK36081.1 - 3.6e-23 82.0 0.0 6.3e-20 71.3 0.0 3.1 2 1 1 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDK36081.1 - 0.0031 16.9 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain adh_short_C2 PF13561.6 EDK36083.2 - 1.3e-53 182.0 0.0 1.5e-53 181.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK36083.2 - 5.4e-48 163.0 0.0 1.3e-47 161.8 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDK36083.2 - 3.8e-14 53.0 0.0 5e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDK36083.2 - 0.0031 16.7 0.1 0.0043 16.2 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EDK36083.2 - 0.0036 16.7 0.0 0.0052 16.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DegQ PF08181.11 EDK36083.2 - 0.14 12.3 0.1 0.38 10.9 0.1 1.8 2 0 0 2 2 2 0 DegQ (SacQ) family WD40 PF00400.32 EDK36084.2 - 1.2e-07 32.3 8.7 4.5e-05 24.1 0.7 4.8 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36084.2 - 1.1e-05 25.6 0.0 0.3 11.4 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK36084.2 - 0.00068 18.4 0.2 0.9 8.1 0.0 2.4 3 0 0 3 3 3 2 Nucleoporin Nup120/160 tRNA_synt_2f PF02092.17 EDK36086.2 - 0.0072 15.3 0.3 0.011 14.7 0.3 1.2 1 0 0 1 1 1 1 Glycyl-tRNA synthetase beta subunit DUF4349 PF14257.6 EDK36086.2 - 0.31 10.5 5.2 0.59 9.6 5.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF465 PF04325.13 EDK36086.2 - 0.43 10.7 4.1 0.33 11.0 1.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Matrilin_ccoil PF10393.9 EDK36086.2 - 1.4 8.8 3.9 12 5.9 3.9 2.6 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin PspB PF06667.12 EDK36086.2 - 1.8 8.7 5.0 1.9 8.6 2.9 2.1 2 0 0 2 2 2 0 Phage shock protein B Cnn_1N PF07989.11 EDK36086.2 - 4.2 7.6 14.7 3.3 8.0 7.1 3.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 RRM_1 PF00076.22 EDK36087.2 - 6e-14 51.6 0.5 5.1e-10 39.0 0.2 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK36087.2 - 0.00032 20.8 0.0 0.00079 19.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EDK36087.2 - 0.06 12.9 0.0 0.16 11.6 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VASP_tetra PF08776.11 EDK36087.2 - 4.1 7.1 11.8 1.1 8.9 7.0 2.4 2 0 0 2 2 2 0 VASP tetramerisation domain DUF5320 PF17253.2 EDK36087.2 - 4.6 8.4 4.9 23 6.1 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF1674 PF07896.12 EDK36088.2 - 8.1e-18 64.6 4.7 1.7e-17 63.6 4.7 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) ARTD15_N PF18084.1 EDK36088.2 - 0.0097 16.1 0.1 0.014 15.6 0.1 1.2 1 0 0 1 1 1 1 ARTD15 N-terminal domain Vma12 PF11712.8 EDK36088.2 - 0.085 12.9 0.1 0.091 12.8 0.1 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Methyltransf_16 PF10294.9 EDK36089.2 - 2e-18 66.8 0.0 3.6e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDK36089.2 - 3.6e-08 33.4 0.0 7.7e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36089.2 - 0.028 15.1 0.0 0.057 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain WD40_3 PF15911.5 EDK36089.2 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat PrmA PF06325.13 EDK36089.2 - 0.24 10.7 0.0 0.39 10.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Aminotran_1_2 PF00155.21 EDK36090.2 - 1.7e-71 241.4 0.0 1.9e-71 241.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDK36090.2 - 0.00011 20.8 0.0 0.00019 20.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDK36090.2 - 0.0024 16.9 0.0 0.0058 15.6 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDK36090.2 - 0.009 15.4 0.0 0.016 14.5 0.0 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family CLN3 PF02487.17 EDK36091.2 - 8.6e-142 472.9 19.0 1.1e-141 472.6 19.0 1.1 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 EDK36091.2 - 5.3e-05 22.3 4.1 5.3e-05 22.3 4.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DAHP_synth_1 PF00793.20 EDK36092.1 - 6.2e-106 353.3 0.0 7.6e-106 353.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family OMPdecase PF00215.24 EDK36092.1 - 0.0098 15.5 0.1 0.019 14.5 0.1 1.5 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF218 PF02698.17 EDK36093.2 - 0.0017 18.4 0.0 0.0023 18.0 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain HAD_2 PF13419.6 EDK36093.2 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HlyIII PF03006.20 EDK36094.1 - 3.4e-52 177.4 12.8 4.2e-52 177.1 12.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4298 PF14131.6 EDK36094.1 - 0.17 11.9 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) NAT PF04768.13 EDK36095.2 - 5.8e-42 143.2 0.2 5.8e-42 143.2 0.2 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Sld5 PF05916.11 EDK36096.2 - 8.7e-21 74.4 0.6 1.3e-20 73.8 0.6 1.2 1 0 0 1 1 1 1 GINS complex protein TTRAP PF14203.6 EDK36096.2 - 0.14 12.1 0.3 0.39 10.7 0.3 1.8 1 1 0 1 1 1 0 Putative tranposon-transfer assisting protein 3-HAO PF06052.12 EDK36098.2 - 7.3 6.2 9.4 3.1 7.4 1.0 2.5 1 1 1 2 2 2 0 3-hydroxyanthranilic acid dioxygenase HbrB PF08539.11 EDK36100.2 - 0.00067 19.7 1.8 0.015 15.3 1.8 3.0 1 1 0 1 1 1 1 HbrB-like U-box PF04564.15 EDK36101.2 - 8.6e-20 70.7 0.0 1.9e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 EDK36101.2 - 0.029 14.2 0.1 0.074 12.9 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.6 EDK36101.2 - 0.05 14.3 0.4 13 6.6 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDK36101.2 - 0.13 12.0 0.3 0.13 12.0 0.3 2.8 2 1 0 2 2 2 0 TPR repeat TPR_1 PF00515.28 EDK36101.2 - 0.15 11.9 13.7 0.77 9.7 0.4 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK36101.2 - 0.24 11.6 8.6 6 7.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF445 PF04286.12 EDK36101.2 - 0.31 10.8 1.7 0.42 10.4 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TPR_17 PF13431.6 EDK36101.2 - 3 8.4 5.4 1.3 9.5 0.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Chitin_synth_1 PF01644.17 EDK36102.2 - 3.1e-74 248.4 1.2 5.2e-74 247.6 1.2 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDK36102.2 - 2.1e-24 85.2 0.3 8e-24 83.4 0.0 2.2 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDK36102.2 - 2.3e-21 76.0 0.0 6.2e-21 74.6 0.0 1.6 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDK36102.2 - 8e-10 39.0 0.0 1.4e-09 38.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDK36102.2 - 0.02 14.8 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase like family 2 MethyltransfD12 PF02086.15 EDK36103.1 - 0.041 13.6 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase RCC1 PF00415.18 EDK36104.2 - 1.2e-64 214.7 0.4 3.4e-12 46.8 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDK36104.2 - 2.4e-37 126.0 25.3 1.2e-08 34.5 0.1 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 EDK36104.2 - 0.065 12.9 0.0 38 3.9 0.0 3.5 4 0 0 4 4 4 0 TUP1-like enhancer of split Rcd1 PF04078.13 EDK36105.1 - 3.2e-116 387.1 2.3 3.9e-116 386.9 2.3 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like MatE PF01554.18 EDK36106.2 - 1.1e-63 213.7 27.4 3.4e-35 121.1 9.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EDK36106.2 - 6.4e-08 32.8 4.5 6.4e-08 32.8 4.5 3.9 3 1 2 5 5 5 2 Polysaccharide biosynthesis C-terminal domain Bystin PF05291.11 EDK36107.2 - 6.2e-124 413.0 0.5 9.6e-124 412.4 0.5 1.3 1 0 0 1 1 1 1 Bystin Nop14 PF04147.12 EDK36107.2 - 0.19 9.9 14.8 0.25 9.5 14.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDK36107.2 - 4.5 6.5 13.8 7.4 5.8 13.8 1.3 1 0 0 1 1 1 0 NOA36 protein PI-PLC-X PF00388.19 EDK36108.2 - 1.7e-52 176.9 0.0 4.5e-52 175.5 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EDK36108.2 - 4.9e-43 146.1 0.1 1.3e-42 144.8 0.1 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EDK36108.2 - 4.7e-08 33.3 0.0 1.1e-07 32.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 EDK36108.2 - 0.00025 21.5 0.2 0.00077 19.9 0.2 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like His_biosynth PF00977.21 EDK36109.2 - 7.6e-44 149.9 0.1 5.1e-43 147.2 0.1 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EDK36109.2 - 1.1e-17 64.5 0.1 1.8e-17 63.8 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EDK36109.2 - 9.3e-06 25.4 0.0 2.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 EDK36109.2 - 0.0033 17.3 0.0 0.41 10.5 0.0 2.4 2 0 0 2 2 2 1 SNO glutamine amidotransferase family NMO PF03060.15 EDK36109.2 - 0.0084 15.5 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EDK36109.2 - 0.05 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Peptidase_S51 PF03575.17 EDK36109.2 - 0.05 13.2 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Peptidase family S51 Peptidase_C26 PF07722.13 EDK36109.2 - 0.1 12.3 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Peptidase C26 PPS_PS PF02006.16 EDK36109.2 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphopantothenate/pantothenate synthetase Methyltransf_11 PF08241.12 EDK36110.2 - 0.00077 20.1 0.0 0.0021 18.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK36110.2 - 0.011 15.5 0.0 0.031 14.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36110.2 - 0.012 16.3 0.0 0.034 14.9 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain BatD PF13584.6 EDK36111.1 - 0.00024 20.1 0.4 0.00029 19.8 0.4 1.1 1 0 0 1 1 1 1 Oxygen tolerance GRP PF07172.11 EDK36111.1 - 0.00024 21.7 0.1 0.00038 21.1 0.1 1.3 1 0 0 1 1 1 1 Glycine rich protein family DUF2207 PF09972.9 EDK36111.1 - 0.002 17.0 0.0 0.002 17.0 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) SARAF PF06682.12 EDK36111.1 - 0.0037 17.0 0.1 0.0041 16.8 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4381 PF14316.6 EDK36111.1 - 0.0053 17.0 0.9 0.0076 16.5 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) FAM209 PF15206.6 EDK36111.1 - 0.015 15.1 0.1 0.02 14.7 0.1 1.1 1 0 0 1 1 1 0 FAM209 family CcmH PF03918.14 EDK36111.1 - 0.028 13.7 0.1 0.041 13.2 0.1 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein EphA2_TM PF14575.6 EDK36111.1 - 0.047 14.6 0.0 0.063 14.2 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5385 PF17359.2 EDK36111.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) OATP PF03137.20 EDK36111.1 - 0.24 9.6 0.0 0.24 9.6 0.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TMEM156 PF15106.6 EDK36111.1 - 0.3 10.5 0.2 0.39 10.1 0.2 1.1 1 0 0 1 1 1 0 TMEM156 protein family AA_permease_2 PF13520.6 EDK36112.2 - 1.8e-50 172.0 38.3 2.3e-50 171.7 38.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK36112.2 - 7.4e-15 54.5 30.0 1e-14 54.1 30.0 1.1 1 0 0 1 1 1 1 Amino acid permease Phosphodiest PF01663.22 EDK36113.2 - 2.6e-15 56.9 1.2 2.6e-13 50.3 1.2 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EDK36113.2 - 2.7e-07 30.2 0.0 4.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EDK36113.2 - 7.2e-05 22.3 0.0 0.0081 15.6 0.0 2.2 1 1 1 2 2 2 2 Sulfatase zf-C2H2_2 PF12756.7 EDK36114.2 - 2.2e-34 117.8 4.4 2.2e-31 108.2 0.4 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Presenilin PF01080.17 EDK36114.2 - 0.89 8.3 1.6 1.2 7.8 1.6 1.2 1 0 0 1 1 1 0 Presenilin DHDPS PF00701.22 EDK36115.2 - 1.3e-35 122.5 0.0 1.5e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_hydrolase PF09370.10 EDK36115.2 - 0.14 11.3 0.1 1.9 7.6 0.0 2.4 1 1 1 2 2 2 0 Phosphoenolpyruvate hydrolase-like Glyco_hydro_88 PF07470.13 EDK36116.2 - 3.3e-12 46.1 1.5 5e-08 32.4 1.5 2.1 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EDK36116.2 - 2e-06 26.6 0.3 5.6e-05 21.8 0.0 2.4 1 1 1 2 2 2 1 Beta-L-arabinofuranosidase, GH127 GlcNAc_2-epim PF07221.11 EDK36116.2 - 5.3e-05 22.6 0.2 0.00015 21.2 0.0 1.7 1 1 1 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) C5-epim_C PF06662.13 EDK36116.2 - 0.00054 19.5 3.3 0.76 9.3 0.2 3.0 2 1 1 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Fungal_trans PF04082.18 EDK36117.2 - 1.2e-67 227.7 2.4 2e-67 227.1 2.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDK36117.2 - 0.0048 17.3 7.1 0.0094 16.4 0.6 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK36117.2 - 0.11 13.4 0.6 0.11 13.4 0.6 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger FOXP-CC PF16159.5 EDK36117.2 - 0.16 12.6 3.5 6.1 7.5 0.0 3.2 3 0 0 3 3 3 0 FOXP coiled-coil domain Aldo_ket_red PF00248.21 EDK36118.1 - 2.8e-18 66.1 0.0 1.1e-10 41.3 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family FOXO_KIX_bdg PF16675.5 EDK36118.1 - 9.9e-05 22.6 0.0 0.00016 21.9 0.0 1.3 1 0 0 1 1 1 1 KIX-binding domain of forkhead box O, CR2 DNA_pol_A_exo1 PF01612.20 EDK36119.2 - 6.6e-45 153.0 0.3 1.4e-44 151.9 0.1 1.7 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 EDK36119.2 - 9.5e-15 55.1 1.1 9.5e-15 55.1 1.1 3.4 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 EDK36119.2 - 5.7e-07 29.4 0.0 2.7e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 HRDC domain MFS_1 PF07690.16 EDK36120.2 - 2.7e-28 98.9 18.0 2.7e-28 98.9 18.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PKS_DE PF18369.1 EDK36120.2 - 0.021 15.4 0.0 0.048 14.2 0.0 1.6 1 0 0 1 1 1 0 Polyketide synthase dimerisation element domain Oxidored_FMN PF00724.20 EDK36121.2 - 4.9e-84 282.5 0.0 5.4e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Cyclin PF08613.11 EDK36122.2 - 4.1e-34 118.3 0.9 5.3e-34 117.9 0.1 1.6 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EDK36122.2 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Metallophos PF00149.28 EDK36123.2 - 1.7e-41 143.0 0.9 2.6e-41 142.4 0.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDK36123.2 - 1.6e-14 54.1 0.5 2.9e-14 53.2 0.5 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain MoCF_biosynth PF00994.24 EDK36124.2 - 6.4e-27 94.0 0.0 1.1e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain Imm44 PF15571.6 EDK36124.2 - 0.0044 17.3 0.2 5.7 7.2 0.0 3.2 3 0 0 3 3 3 2 Immunity protein 44 AA_kinase PF00696.28 EDK36124.2 - 0.092 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Amino acid kinase family tRNA-synt_2c PF01411.19 EDK36125.1 - 4.1e-224 745.2 0.1 7.7e-224 744.3 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDK36125.1 - 2.8e-18 65.7 0.4 8.5e-18 64.2 0.4 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EDK36125.1 - 7.6e-14 52.3 2.5 2.4e-13 50.7 2.5 1.9 1 0 0 1 1 1 1 DHHA1 domain Cas_TM1802 PF09484.10 EDK36125.1 - 0.29 9.8 5.8 6.2 5.4 0.1 2.2 2 0 0 2 2 2 0 CRISPR-associated protein TM1802 (cas_TM1802) Copper-fist PF00649.18 EDK36126.2 - 4.6e-19 67.6 1.2 1e-18 66.5 1.2 1.6 1 0 0 1 1 1 1 Copper fist DNA binding domain HSF_DNA-bind PF00447.17 EDK36127.2 - 2.2e-30 105.1 2.6 5.5e-30 103.8 2.6 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding DUF3320 PF11784.8 EDK36127.2 - 0.2 11.6 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) Fungal_trans_2 PF11951.8 EDK36128.2 - 1.3e-38 132.9 0.0 1.9e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK36128.2 - 7.5e-07 29.2 12.5 1.5e-06 28.2 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 EDK36129.2 - 1e-08 34.8 0.0 5.6e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK36129.2 - 5.6e-08 32.3 0.0 4.6e-06 26.0 0.0 2.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDK36129.2 - 4.4e-05 23.5 0.1 0.92 9.5 0.2 3.4 3 1 1 4 4 4 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EDK36129.2 - 0.00023 20.5 0.0 0.22 10.8 0.1 3.5 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EDK36129.2 - 0.004 17.2 0.0 0.07 13.2 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EDK36129.2 - 0.011 16.2 2.2 0.69 10.5 0.0 3.2 3 1 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDK36129.2 - 0.018 15.4 0.1 9.4 6.7 0.0 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.18 EDK36129.2 - 0.052 13.8 0.1 0.46 10.8 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EDK36129.2 - 0.075 12.3 0.0 6.8 5.9 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EDK36129.2 - 0.19 11.0 0.1 15 4.7 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EDK36129.2 - 0.25 10.9 0.1 38 3.7 0.0 3.2 3 1 1 4 4 4 0 FAD dependent oxidoreductase MCR PF18509.1 EDK36129.2 - 0.68 9.6 3.3 2.3 7.8 0.3 2.7 3 0 0 3 3 3 0 Magnetochrome domain Dak1 PF02733.17 EDK36130.2 - 1.8e-106 355.6 0.4 2.4e-106 355.1 0.4 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EDK36130.2 - 1e-47 162.3 0.1 2e-47 161.3 0.1 1.5 1 0 0 1 1 1 1 DAK2 domain Fungal_trans_2 PF11951.8 EDK36131.2 - 3.1e-100 335.7 1.0 4.3e-100 335.2 1.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK36131.2 - 3.5e-10 39.8 3.5 6.4e-10 39.0 3.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flocculin_t3 PF13928.6 EDK36133.1 - 3e-16 59.6 42.4 7.1e-13 48.8 24.7 4.8 4 1 0 4 4 4 2 Flocculin type 3 repeat DEC-1_N PF04625.13 EDK36133.1 - 0.092 11.7 3.7 0.094 11.7 3.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region ERO1 PF04137.15 EDK36134.2 - 3.5e-115 385.0 0.2 4.7e-115 384.6 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DEAD PF00270.29 EDK36135.2 - 3.7e-51 173.4 0.0 9.9e-51 172.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK36135.2 - 5e-36 123.4 0.3 1.5e-31 109.0 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain MDM1 PF15501.6 EDK36135.2 - 4.7e-06 26.0 11.8 7.6e-06 25.4 11.6 1.4 2 0 0 2 2 2 1 Nuclear protein MDM1 AAA_11 PF13086.6 EDK36135.2 - 0.00025 20.9 13.7 0.0005 19.9 12.3 2.0 2 0 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.5 EDK36135.2 - 0.00046 19.5 0.0 0.00046 19.5 0.0 2.3 2 0 0 2 2 1 1 ERCC3/RAD25/XPB C-terminal helicase eIF3_subunit PF08597.10 EDK36135.2 - 0.0009 19.2 30.0 0.0018 18.2 30.0 1.4 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Tim54 PF11711.8 EDK36135.2 - 0.0067 15.3 18.2 0.011 14.5 18.2 1.3 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 EDK36135.2 - 0.016 15.4 3.5 0.031 14.5 3.5 1.5 1 0 0 1 1 1 0 DDHD domain CMS1 PF14617.6 EDK36135.2 - 0.067 12.5 0.1 0.067 12.5 0.1 3.4 2 1 1 3 3 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 EDK36135.2 - 0.13 12.6 1.7 1.2 9.4 0.7 2.9 1 1 1 2 2 2 0 AAA domain Otopetrin PF03189.13 EDK36135.2 - 0.22 10.3 1.1 0.27 10.0 1.1 1.1 1 0 0 1 1 1 0 Otopetrin RseA_C PF03873.13 EDK36135.2 - 0.61 10.4 0.0 0.61 10.4 0.0 2.4 3 0 0 3 3 1 0 Anti sigma-E protein RseA, C-terminal domain DDRGK PF09756.9 EDK36135.2 - 0.77 9.3 35.2 1.5 8.4 35.2 1.4 1 0 0 1 1 1 0 DDRGK domain CPSF100_C PF13299.6 EDK36135.2 - 0.8 9.9 19.5 3 8.0 18.9 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Tfb4 PF03850.14 EDK36135.2 - 1.5 8.2 3.7 2.8 7.3 3.7 1.4 1 0 0 1 1 1 0 Transcription factor Tfb4 Miga PF10265.9 EDK36135.2 - 1.6 7.7 9.9 2.4 7.0 9.9 1.1 1 0 0 1 1 1 0 Mitoguardin GREB1 PF15782.5 EDK36135.2 - 1.9 5.5 9.8 2.5 5.1 9.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 EDK36135.2 - 5.5 5.0 19.0 7.9 4.5 19.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3807 PF12720.7 EDK36135.2 - 5.7 7.2 29.8 9.1 6.5 29.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF2151 PF10221.9 EDK36135.2 - 5.8 5.4 23.3 8.8 4.8 23.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator TFIIF_alpha PF05793.12 EDK36135.2 - 6.4 5.3 38.9 9.5 4.7 38.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NARP1 PF12569.8 EDK36135.2 - 6.6 5.5 30.3 9.5 5.0 30.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Draxin PF15550.6 EDK36135.2 - 7.2 6.4 20.2 13 5.6 20.2 1.3 1 0 0 1 1 1 0 Draxin SOBP PF15279.6 EDK36135.2 - 8 7.0 10.8 13 6.3 10.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Peptidase_S64 PF08192.11 EDK36135.2 - 8.9 4.7 15.9 13 4.1 15.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF4551 PF15087.6 EDK36135.2 - 9.2 5.0 14.1 13 4.4 14.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Vfa1 PF08432.10 EDK36135.2 - 9.5 6.5 37.5 17 5.7 37.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 UCH_1 PF13423.6 EDK36137.2 - 2e-57 195.2 0.0 2.7e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EDK36137.2 - 8.3e-23 81.7 0.0 1.3e-22 81.1 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EDK36137.2 - 1.7e-08 34.2 0.1 3.3e-08 33.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40_like PF17005.5 EDK36137.2 - 0.084 12.2 0.1 0.18 11.1 0.1 1.5 1 0 0 1 1 1 0 WD40-like domain eIF2A PF08662.11 EDK36137.2 - 0.14 12.0 0.0 0.57 10.0 0.0 2.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A TCO89 PF10452.9 EDK36138.2 - 1e-11 44.5 59.1 1.2e-07 31.1 2.6 3.4 1 1 0 2 2 2 2 TORC1 subunit TCO89 Adaptin_N PF01602.20 EDK36139.2 - 7.5e-99 331.7 10.3 1.1e-98 331.1 10.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EDK36139.2 - 9.2e-45 152.5 3.1 9.2e-45 152.5 3.1 2.6 3 0 0 3 3 3 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EDK36139.2 - 7.3e-32 109.9 0.0 2.5e-31 108.2 0.0 2.0 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EDK36139.2 - 4.3e-14 52.7 0.1 1.9e-07 31.4 0.0 5.4 4 1 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 EDK36139.2 - 3.3e-09 37.0 15.7 0.012 15.7 0.2 6.6 6 1 0 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDK36139.2 - 0.018 15.5 2.6 12 6.5 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat HEAT PF02985.22 EDK36139.2 - 0.032 14.5 5.7 8.9 6.9 0.1 5.7 6 0 0 6 6 6 0 HEAT repeat PAC3 PF10178.9 EDK36139.2 - 0.08 13.1 0.1 0.29 11.3 0.1 2.0 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 UPF0253 PF06786.12 EDK36139.2 - 0.084 13.2 0.0 0.99 9.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0253) OPT PF03169.15 EDK36140.2 - 1.2e-178 595.7 42.4 1.4e-178 595.4 42.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Atx10homo_assoc PF09759.9 EDK36141.2 - 9.2e-37 125.0 3.8 1.3e-36 124.6 1.3 2.5 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain RsbRD_N PF14361.6 EDK36141.2 - 0.2 12.4 2.7 4.5 8.0 0.5 2.9 2 1 1 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain Anth_synt_I_N PF04715.13 EDK36141.2 - 0.21 11.8 1.3 0.48 10.6 0.1 2.3 3 0 0 3 3 3 0 Anthranilate synthase component I, N terminal region Arm PF00514.23 EDK36141.2 - 0.21 11.7 1.3 6.9 6.9 0.0 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat NBD94 PF16830.5 EDK36141.2 - 0.47 10.9 0.0 0.47 10.9 0.0 3.0 3 1 0 3 3 3 0 Nucleotide-Binding Domain 94 of RH Thr_synth_N PF14821.6 EDK36142.2 - 3.6e-30 104.0 0.0 1e-29 102.5 0.0 1.8 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EDK36142.2 - 4.1e-15 56.0 0.0 7.1e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ROS_MUCR PF05443.11 EDK36142.2 - 0.13 12.3 0.0 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Tam41_Mmp37 PF09139.11 EDK36143.2 - 9e-102 340.8 0.0 1.2e-101 340.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial EABR PF12180.8 EDK36143.2 - 0.14 11.8 0.5 1.2 8.9 0.5 2.2 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 Gti1_Pac2 PF09729.9 EDK36144.2 - 1.7e-30 106.4 0.5 1e-26 94.1 0.0 2.3 1 1 1 2 2 2 2 Gti1/Pac2 family SPX PF03105.19 EDK36144.2 - 1.7 8.5 6.3 2.2 8.1 6.3 1.2 1 0 0 1 1 1 0 SPX domain SAP30_Sin3_bdg PF13867.6 EDK36145.2 - 1.1e-08 35.3 0.3 2.1e-07 31.2 0.2 2.4 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 CUE PF02845.16 EDK36146.2 - 7.1e-10 38.4 0.0 1.2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 EDK36147.2 - 2.3e-25 88.4 13.8 0.00013 22.7 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36147.2 - 3e-15 56.3 0.1 0.0035 17.6 0.0 5.9 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK36147.2 - 2.3e-07 30.1 0.2 0.023 13.7 0.0 3.7 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK36147.2 - 7.8e-06 25.9 0.1 0.02 14.8 0.0 4.2 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EDK36147.2 - 0.00091 18.4 0.1 0.4 9.7 0.0 2.8 2 1 1 3 3 3 2 Coatomer WD associated region PD40 PF07676.12 EDK36147.2 - 0.0066 16.4 4.4 3.2 7.8 0.0 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EDK36147.2 - 0.0092 15.3 0.1 0.34 10.2 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain DUF5122 PF17164.4 EDK36147.2 - 0.14 12.5 2.5 5.6 7.3 0.0 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller Sen15 PF09631.10 EDK36147.2 - 0.15 12.3 0.1 2.1 8.7 0.0 2.5 2 0 0 2 2 2 0 Sen15 protein Peptidase_M18 PF02127.15 EDK36148.2 - 9.7e-128 426.6 0.0 1.1e-127 426.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDK36148.2 - 0.0056 15.7 0.1 0.043 12.8 0.0 2.0 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Sugar_tr PF00083.24 EDK36149.2 - 5.4e-91 305.7 16.9 6.4e-91 305.5 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK36149.2 - 1.3e-27 96.6 22.3 3.5e-18 65.7 1.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Ribosomal_L7Ae PF01248.26 EDK36151.1 - 5.9e-28 96.4 0.3 1.8e-27 94.9 0.2 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Swi3 PF07962.12 EDK36151.1 - 0.033 14.2 0.1 0.061 13.3 0.1 1.4 1 0 0 1 1 1 0 Replication Fork Protection Component Swi3 Trypan_glycop PF00913.19 EDK36152.2 - 0.0021 17.4 0.1 0.003 16.9 0.1 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Adaptin_N PF01602.20 EDK36153.2 - 8.9e-100 334.7 11.8 8.9e-100 334.7 11.8 1.4 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EDK36153.2 - 3.8e-56 188.6 0.0 1e-55 187.1 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EDK36153.2 - 9.9e-53 177.8 0.8 9.9e-53 177.8 0.8 2.0 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 EDK36153.2 - 3.5e-12 46.5 2.3 1.5e-06 28.5 0.0 5.0 1 1 4 5 5 5 3 HEAT repeats Cnd1 PF12717.7 EDK36153.2 - 3.9e-10 40.0 9.3 1.7e-07 31.4 0.1 3.8 1 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EDK36153.2 - 1.4e-06 28.0 0.7 0.023 14.9 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat Coatomer_g_Cpla PF16381.5 EDK36153.2 - 0.00016 21.8 0.0 0.00075 19.6 0.0 2.3 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_EZ PF13513.6 EDK36153.2 - 0.0018 18.7 0.0 0.77 10.3 0.0 4.1 3 1 1 4 4 4 1 HEAT-like repeat DUF5578 PF17741.1 EDK36153.2 - 0.0036 16.8 7.1 0.011 15.1 0.4 2.9 2 1 1 3 3 3 1 Family of unknown function (DUF5578) DUF3535 PF12054.8 EDK36153.2 - 0.017 14.4 0.8 0.048 12.9 0.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) AP4E_app_platf PF14807.6 EDK36153.2 - 0.04 14.3 0.4 0.21 12.0 0.0 2.6 3 0 0 3 3 1 0 Adaptin AP4 complex epsilon appendage platform FANCI_S2 PF14676.6 EDK36153.2 - 0.2 11.9 4.5 0.2 11.9 1.3 2.8 4 0 0 4 4 4 0 FANCI solenoid 2 Peptidase_M24 PF00557.24 EDK36154.1 - 4.6e-13 49.4 0.0 4.9e-13 49.2 0.0 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 PHD PF00628.29 EDK36155.2 - 8.5e-10 38.4 35.9 9.6e-07 28.6 16.8 2.8 2 1 1 3 3 3 2 PHD-finger zf-HC5HC2H_2 PF13832.6 EDK36155.2 - 4.9 7.4 15.2 4.8 7.4 1.3 2.4 2 0 0 2 2 2 0 PHD-zinc-finger like domain L51_S25_CI-B8 PF05047.16 EDK36156.1 - 2.9e-10 39.9 0.0 4.5e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ArgJ PF01960.18 EDK36157.2 - 2.5e-148 493.8 4.4 2.8e-148 493.6 4.4 1.0 1 0 0 1 1 1 1 ArgJ family adh_short PF00106.25 EDK36159.2 - 3.1e-41 141.0 0.0 5.9e-41 140.1 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK36159.2 - 1.9e-29 102.9 0.0 2.8e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK36159.2 - 3.3e-06 27.1 0.4 0.0001 22.3 0.0 2.1 2 0 0 2 2 2 1 KR domain PALP PF00291.25 EDK36159.2 - 0.064 12.7 0.0 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Iwr1 PF08574.10 EDK36160.2 - 2.3e-15 57.4 14.8 2.3e-15 57.4 14.8 3.0 2 1 1 3 3 3 1 Transcription factor Iwr1 RNA_pol PF00940.19 EDK36161.2 - 2.5e-138 461.4 0.2 4.4e-138 460.6 0.2 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EDK36161.2 - 1.4e-15 57.6 0.0 5.6e-14 52.3 0.0 2.4 1 1 1 2 2 2 2 DNA-directed RNA polymerase N-terminal TRAPP PF04051.16 EDK36162.2 - 9.5e-37 125.9 0.0 1.2e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component RRM_1 PF00076.22 EDK36163.2 - 6.8e-15 54.6 0.0 2.4e-11 43.3 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EDK36164.2 - 5.7e-40 137.4 0.0 1.3e-39 136.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36164.2 - 4.3e-25 88.5 0.0 1.3e-24 86.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36164.2 - 1e-07 31.6 0.0 3.8e-06 26.4 0.0 2.6 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDK36164.2 - 0.0025 17.2 0.0 0.0043 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDK36164.2 - 0.02 14.5 0.0 0.044 13.4 0.0 1.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SUR7 PF06687.12 EDK36165.1 - 8.7e-40 136.6 12.1 1e-39 136.4 12.1 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EDK36165.1 - 0.078 12.9 10.1 0.17 11.8 10.1 1.5 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 H_PPase PF03030.16 EDK36165.1 - 0.08 11.6 7.1 0.14 10.8 7.1 1.3 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase SseC PF04888.12 EDK36165.1 - 0.99 8.9 4.7 1.3 8.5 4.7 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Claudin_2 PF13903.6 EDK36165.1 - 5.1 6.8 13.8 0.093 12.5 3.5 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2256 PF10013.9 EDK36166.2 - 0.0075 16.4 1.2 0.018 15.2 1.2 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2256) Haemocyan_bet_s PF14830.6 EDK36166.2 - 0.068 13.2 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Haemocyanin beta-sandwich MF_alpha_N PF05436.11 EDK36167.1 - 0.0045 16.8 0.4 0.0083 16.0 0.4 1.4 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus Plasmodium_Vir PF05795.11 EDK36167.1 - 0.15 11.5 3.4 16 4.7 0.1 3.3 1 1 2 3 3 3 0 Plasmodium vivax Vir protein TB2_DP1_HVA22 PF03134.19 EDK36167.1 - 0.37 10.8 5.5 60 3.7 0.1 4.2 2 1 2 4 4 4 0 TB2/DP1, HVA22 family DUF5051 PF16473.5 EDK36168.2 - 0.042 13.8 0.4 0.069 13.1 0.4 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Fungal_lectin_2 PF18647.1 EDK36169.2 - 0.054 14.0 1.2 0.13 12.8 1.2 1.6 1 0 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin ARGLU PF15346.6 EDK36169.2 - 1.5 8.6 14.4 2.7 7.9 12.7 1.9 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 RNase_H PF00075.24 EDK36170.1 - 6.6e-26 91.2 0.3 1.2e-25 90.3 0.3 1.4 1 1 0 1 1 1 1 RNase H CDC13_N PF16853.5 EDK36170.1 - 0.019 14.5 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus GCP5-Mod21 PF14609.6 EDK36171.2 - 0.025 13.0 0.1 0.034 12.5 0.1 1.1 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 Bac_export_2 PF01312.19 EDK36171.2 - 0.14 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Rab5ip PF07019.12 EDK36171.2 - 0.18 12.4 3.9 0.42 11.2 3.9 1.7 1 1 0 1 1 1 0 Rab5-interacting protein (Rab5ip) GPDPase_memb PF10110.9 EDK36172.2 - 0.0097 14.7 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 1 Membrane domain of glycerophosphoryl diester phosphodiesterase ETRAMP PF09716.10 EDK36172.2 - 4.6 7.4 7.8 2.7 8.1 0.2 2.9 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) ABC_tran_CTD PF16326.5 EDK36173.2 - 0.011 16.0 1.7 0.016 15.4 0.3 1.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain TRPM_tetra PF16519.5 EDK36173.2 - 0.021 14.9 0.3 0.048 13.8 0.3 1.6 1 0 0 1 1 1 0 Tetramerisation domain of TRPM DUF4795 PF16043.5 EDK36173.2 - 0.038 13.6 2.6 0.049 13.2 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) ZapB PF06005.12 EDK36173.2 - 0.041 14.3 0.8 0.1 13.1 0.2 1.9 2 0 0 2 2 2 0 Cell division protein ZapB DUF4988 PF16378.5 EDK36173.2 - 0.083 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function AAA_32 PF13654.6 EDK36173.2 - 0.1 11.3 1.2 0.17 10.7 1.2 1.2 1 0 0 1 1 1 0 AAA domain YlbD_coat PF14071.6 EDK36173.2 - 0.13 12.5 1.3 0.28 11.5 1.3 1.5 1 0 0 1 1 1 0 Putative coat protein CHD5 PF04420.14 EDK36173.2 - 0.17 11.8 0.4 0.34 10.8 0.4 1.5 1 0 0 1 1 1 0 CHD5-like protein XhlA PF10779.9 EDK36173.2 - 0.17 12.1 1.2 0.38 11.0 0.5 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Occludin_ELL PF07303.13 EDK36173.2 - 0.25 12.1 2.9 0.2 12.4 0.9 1.8 2 0 0 2 2 2 0 Occludin homology domain DUF1664 PF07889.12 EDK36173.2 - 0.31 11.1 1.7 0.33 11.0 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SH3_1 PF00018.28 EDK36175.2 - 1.4e-07 31.0 0.0 3.3e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 EDK36175.2 - 5e-06 26.3 2.3 5e-06 26.3 2.3 1.9 2 0 0 2 2 2 1 BAR domain SH3_2 PF07653.17 EDK36175.2 - 7e-06 25.6 0.1 1.9e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EDK36175.2 - 1.3e-05 25.0 0.0 2.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Staygreen PF12638.7 EDK36175.2 - 0.027 14.2 0.7 5.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Staygreen protein LPD39 PF18858.1 EDK36175.2 - 0.091 12.8 1.7 0.19 11.8 0.6 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 39 BAR_3 PF16746.5 EDK36175.2 - 4 7.1 12.6 0.45 10.2 2.8 2.4 1 1 0 2 2 2 0 BAR domain of APPL family Abhydrolase_1 PF00561.20 EDK36176.2 - 1.1e-15 58.0 0.0 3.3e-15 56.4 0.0 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK36176.2 - 4.6e-09 35.9 0.0 1.1e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK36176.2 - 0.012 16.2 0.0 0.032 14.8 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family HEAT PF02985.22 EDK36177.2 - 2.6e-08 33.4 0.1 0.01 16.0 0.1 4.1 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 EDK36177.2 - 3.3e-06 27.4 0.0 0.0098 16.3 0.0 3.0 2 0 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 EDK36177.2 - 1.3e-05 25.6 0.3 1.5 9.4 0.0 4.3 4 0 0 4 4 4 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDK36177.2 - 9.4e-05 22.9 0.0 0.029 15.0 0.0 3.4 1 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 EDK36177.2 - 0.00014 21.8 0.4 11 6.3 0.0 4.6 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EDK36177.2 - 0.00073 19.6 5.2 0.00082 19.5 0.9 3.4 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 DASH_Dad4 PF08650.10 EDK36177.2 - 0.022 14.7 2.9 6.7 6.8 0.1 4.2 4 0 0 4 4 4 0 DASH complex subunit Dad4 DUF3349 PF11829.8 EDK36177.2 - 0.092 13.5 0.1 0.99 10.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3349) Noelin-1 PF12308.8 EDK36177.2 - 0.1 12.6 3.9 0.11 12.5 1.0 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein HEAT PF02985.22 EDK36178.2 - 0.084 13.2 1.3 18 5.9 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat GLE1 PF07817.13 EDK36179.2 - 1e-81 273.9 0.9 1e-81 273.9 0.9 1.8 2 0 0 2 2 2 1 GLE1-like protein DUF5401 PF17380.2 EDK36179.2 - 0.18 9.8 26.6 0.28 9.2 26.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) FAM76 PF16046.5 EDK36179.2 - 0.74 9.1 17.1 1.2 8.4 17.1 1.3 1 0 0 1 1 1 0 FAM76 protein Asp-B-Hydro_N PF05279.11 EDK36179.2 - 0.88 9.6 17.2 1.3 9.0 17.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GBP_C PF02841.14 EDK36179.2 - 5.1 6.4 26.2 8.4 5.7 26.2 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain RR_TM4-6 PF06459.12 EDK36179.2 - 5.2 6.8 16.7 8.7 6.1 16.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EDK36179.2 - 6.5 4.9 16.1 9 4.5 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L5_C PF00673.21 EDK36180.2 - 8.3e-29 99.6 0.0 1.3e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDK36180.2 - 0.0015 18.8 0.0 0.0027 18.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 DUF2439 PF10382.9 EDK36181.2 - 1.9e-20 72.9 0.0 3.1e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) GGDEF PF00990.21 EDK36181.2 - 0.19 11.4 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Diguanylate cyclase, GGDEF domain zf-C2H2 PF00096.26 EDK36183.2 - 9.4e-05 22.7 3.0 9.4e-05 22.7 3.0 3.4 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK36183.2 - 0.068 14.0 2.4 0.068 14.0 2.4 3.7 3 1 0 3 3 3 0 C2H2-type zinc finger TPR_14 PF13428.6 EDK36184.2 - 1.2e-06 28.9 0.7 0.019 15.8 0.1 5.1 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36184.2 - 8.5e-06 26.3 0.1 0.00063 20.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36184.2 - 3.2e-05 24.4 0.0 1.1 9.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDK36184.2 - 0.00019 21.4 1.5 0.11 12.7 0.2 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK36184.2 - 0.00027 20.3 0.9 0.12 11.6 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDK36184.2 - 0.00064 19.6 0.8 0.0084 16.2 0.4 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDK36184.2 - 0.0023 17.9 11.8 5.6 7.0 0.2 4.9 2 2 1 4 4 4 1 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 EDK36184.2 - 0.0067 16.7 0.3 0.28 11.5 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDK36184.2 - 0.032 14.3 0.9 0.28 11.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.10 EDK36184.2 - 0.041 13.0 2.7 0.12 11.5 0.3 2.7 2 1 0 2 2 2 0 NRDE-2, necessary for RNA interference ANAPC3 PF12895.7 EDK36184.2 - 0.055 13.7 2.0 19 5.6 0.2 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HAT PF02184.16 EDK36184.2 - 0.58 10.2 7.9 7.4 6.6 0.1 3.7 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Na_Ca_ex PF01699.24 EDK36185.2 - 5.4e-31 107.6 45.4 1.9e-19 70.1 21.1 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Flavokinase PF01687.17 EDK36186.2 - 9.5e-31 106.4 0.0 1.1e-30 106.1 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Peptidase_C48 PF02902.19 EDK36187.2 - 1.2e-35 123.4 0.1 2.6e-35 122.2 0.1 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain RNA12 PF10443.9 EDK36188.2 - 2.3e-157 524.3 0.9 1.4e-101 340.4 0.2 2.5 2 1 1 3 3 3 2 RNA12 protein ATPase_2 PF01637.18 EDK36188.2 - 0.0011 18.9 4.2 0.0018 18.3 0.8 2.5 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 EDK36188.2 - 0.0029 17.4 0.0 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_13 PF13166.6 EDK36188.2 - 0.069 11.8 0.7 0.28 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2487 PF10673.9 EDK36188.2 - 0.092 12.8 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) AAA PF00004.29 EDK36189.2 - 1.4e-36 125.8 0.0 2.3e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK36189.2 - 8.9e-12 44.6 0.0 1.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDK36189.2 - 2.5e-06 28.0 0.3 0.00054 20.4 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDK36189.2 - 6.2e-06 26.1 0.0 2.4e-05 24.1 0.0 1.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EDK36189.2 - 4.3e-05 23.6 0.0 7.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDK36189.2 - 7e-05 23.0 0.0 0.00015 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDK36189.2 - 0.00021 21.3 0.1 0.0024 17.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK36189.2 - 0.00035 20.8 0.4 0.051 13.8 0.0 3.0 1 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EDK36189.2 - 0.00043 20.5 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDK36189.2 - 0.001 18.5 0.1 0.0027 17.1 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDK36189.2 - 0.0015 18.9 0.0 0.0058 17.0 0.0 2.1 2 1 0 2 2 1 1 RNA helicase IstB_IS21 PF01695.17 EDK36189.2 - 0.0017 18.1 0.0 0.004 16.9 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EDK36189.2 - 0.0021 18.6 0.0 0.0046 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EDK36189.2 - 0.0023 17.3 0.0 0.98 8.8 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein Parvo_NS1 PF01057.17 EDK36189.2 - 0.0027 16.9 0.0 0.0038 16.3 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EDK36189.2 - 0.0032 17.0 0.1 0.014 14.9 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 EDK36189.2 - 0.0045 16.7 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EDK36189.2 - 0.008 16.1 0.3 0.034 14.0 0.1 2.1 2 0 0 2 2 2 1 NACHT domain TIP49 PF06068.13 EDK36189.2 - 0.0091 15.2 0.1 0.024 13.9 0.1 1.7 1 1 1 2 2 2 1 TIP49 P-loop domain Hydin_ADK PF17213.3 EDK36189.2 - 0.012 15.9 0.0 3.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Sigma54_activ_2 PF14532.6 EDK36189.2 - 0.013 15.6 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 EDK36189.2 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EDK36189.2 - 0.023 14.6 0.2 0.14 12.0 0.0 2.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 EDK36189.2 - 0.029 14.3 0.1 0.088 12.7 0.0 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_17 PF13207.6 EDK36189.2 - 0.038 14.4 0.0 0.15 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDK36189.2 - 0.048 13.4 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 EDK36189.2 - 0.05 13.2 0.1 0.92 9.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDK36189.2 - 0.051 14.1 0.0 0.15 12.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 EDK36189.2 - 0.065 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EDK36189.2 - 0.077 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.18 EDK36189.2 - 0.083 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EDK36189.2 - 0.09 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EDK36189.2 - 0.093 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 EDK36189.2 - 0.14 12.0 0.0 0.27 11.0 0.0 1.5 1 1 0 1 1 1 0 Bacterial dnaA protein MIF4G PF02854.19 EDK36190.2 - 4.4e-23 82.0 1.1 1.4e-19 70.6 0.8 2.7 2 0 0 2 2 2 2 MIF4G domain MA3 PF02847.17 EDK36190.2 - 4.3e-20 71.8 0.2 1.7e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 MA3 domain BORCS6 PF10157.9 EDK36190.2 - 0.14 12.4 3.5 4.5 7.5 0.7 2.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 tRNA_U5-meth_tr PF05958.11 EDK36191.2 - 1.7e-18 66.7 0.1 2.8e-18 66.0 0.1 1.3 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EDK36191.2 - 5.4e-09 36.0 0.1 1.9e-08 34.2 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36191.2 - 6.5e-07 30.0 0.0 4.1e-06 27.4 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 EDK36191.2 - 3.5e-06 26.7 0.0 8.4e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EDK36191.2 - 1e-05 25.6 0.0 3.4e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain TRAM PF01938.20 EDK36191.2 - 2.3e-05 24.3 0.2 7.3e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 TRAM domain Methyltransf_15 PF09445.10 EDK36191.2 - 2.7e-05 23.8 0.0 7.7e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EDK36191.2 - 6.3e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EDK36191.2 - 6.7e-05 22.4 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EDK36191.2 - 0.001 18.5 0.0 0.0027 17.1 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EDK36191.2 - 0.0023 18.5 0.1 0.017 15.8 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36191.2 - 0.0056 17.4 0.1 0.028 15.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EDK36191.2 - 0.08 12.7 0.0 0.16 11.7 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CmcI PF04989.12 EDK36191.2 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_4 PF02390.17 EDK36191.2 - 0.09 12.2 0.2 0.27 10.7 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase SMC_N PF02463.19 EDK36192.2 - 3.4e-62 209.8 7.7 1.4e-61 207.8 7.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDK36192.2 - 1.5e-25 89.7 0.4 6.5e-25 87.7 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDK36192.2 - 4.2e-14 53.1 7.8 3.2e-07 30.5 0.3 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDK36192.2 - 7.3e-08 33.1 31.2 7.3e-08 33.1 31.2 6.4 3 2 1 5 5 3 1 AAA domain AAA_29 PF13555.6 EDK36192.2 - 3.8e-07 29.7 0.0 9e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EDK36192.2 - 2e-06 27.8 29.3 2e-06 27.8 29.3 4.4 2 2 0 2 2 1 1 AAA ATPase domain JIP_LZII PF16471.5 EDK36192.2 - 0.00062 19.9 3.2 0.00062 19.9 3.2 9.3 9 1 0 10 10 10 1 JNK-interacting protein leucine zipper II ATG16 PF08614.11 EDK36192.2 - 0.0072 16.6 11.8 0.0072 16.6 11.8 7.2 4 1 1 6 6 5 2 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 EDK36192.2 - 0.064 13.5 0.0 0.31 11.3 0.0 2.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Baculo_PEP_C PF04513.12 EDK36192.2 - 0.065 13.3 33.7 2 8.5 1.2 6.4 5 2 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus TM1506 PF08973.10 EDK36192.2 - 0.073 12.7 0.2 0.073 12.7 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1893) MukB PF04310.12 EDK36192.2 - 0.13 12.1 0.0 0.13 12.1 0.0 3.6 5 0 0 5 5 4 0 MukB N-terminal AAA_27 PF13514.6 EDK36192.2 - 0.15 11.6 0.0 0.15 11.6 0.0 6.4 7 1 0 7 7 6 0 AAA domain WcbI PF18588.1 EDK36192.2 - 0.24 11.0 0.9 0.59 9.7 0.1 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis enzyme WcbI FPP PF05911.11 EDK36192.2 - 2.4 6.3 97.2 0.0092 14.2 21.6 5.4 3 2 1 5 5 5 0 Filament-like plant protein, long coiled-coil ABC_tran PF00005.27 EDK36192.2 - 4.9 7.7 25.6 15 6.1 0.0 6.1 3 3 1 4 4 4 0 ABC transporter Creatinase_N_2 PF16189.5 EDK36193.2 - 1.3e-43 148.9 1.2 3.5e-42 144.2 0.2 2.8 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 EDK36193.2 - 6.6e-12 46.2 0.0 6.7e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain DUF148 PF02520.17 EDK36193.2 - 0.061 13.4 1.8 0.63 10.2 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF148 SUB1_ProdP9 PF18213.1 EDK36193.2 - 0.061 13.2 0.4 0.27 11.1 0.2 2.1 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 DUF4363 PF14276.6 EDK36193.2 - 0.072 13.2 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) DUF3020 PF11223.8 EDK36194.2 - 6.1e-20 71.5 11.2 6.1e-20 71.5 11.2 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3020) Cnd1 PF12717.7 EDK36194.2 - 0.56 10.2 3.6 0.6 10.1 1.9 1.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF1769 PF08588.10 EDK36195.1 - 1.9e-22 79.2 0.1 3.1e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) CMV_1a PF12467.8 EDK36195.1 - 0.16 12.3 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family TAL_FSA PF00923.19 EDK36196.2 - 5e-98 328.0 1.1 5.7e-98 327.8 1.1 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase VTC PF09359.10 EDK36197.2 - 1.6e-86 290.2 3.4 3.2e-86 289.2 3.4 1.5 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EDK36197.2 - 9.1e-12 45.6 17.6 0.00049 20.1 0.0 4.3 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 EDK36197.2 - 5.3e-11 42.8 2.5 5.3e-11 42.8 2.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Clat_adaptor_s PF01217.20 EDK36198.2 - 2.9e-16 59.7 0.5 3.7e-16 59.4 0.5 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PTR2 PF00854.21 EDK36199.2 - 6.9e-57 193.1 10.8 9.5e-57 192.6 10.8 1.2 1 0 0 1 1 1 1 POT family Bromo_TP PF07524.13 EDK36200.2 - 2.3e-07 30.7 0.0 4.2e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 EDK36200.2 - 0.0021 18.2 0.1 0.0052 16.9 0.0 1.7 2 0 0 2 2 2 1 Histone-fold protein TFIID-31kDa PF02291.15 EDK36200.2 - 0.02 15.0 0.0 0.058 13.5 0.0 1.7 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit RinB PF06116.12 EDK36200.2 - 0.14 12.2 0.2 1 9.5 0.1 2.1 2 0 0 2 2 2 0 Transcriptional activator RinB Exo5 PF09810.9 EDK36202.2 - 1.9e-47 162.5 0.2 4.5e-47 161.3 0.2 1.5 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EDK36202.2 - 1e-07 32.2 0.2 0.00011 22.2 0.0 2.7 3 0 0 3 3 3 2 PD-(D/E)XK nuclease superfamily OCRE PF17780.1 EDK36202.2 - 0.035 14.1 1.1 0.085 12.9 1.1 1.7 1 0 0 1 1 1 0 OCRE domain Sugar_tr PF00083.24 EDK36203.2 - 9e-89 298.4 18.4 1e-88 298.2 18.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK36203.2 - 5.8e-31 107.7 28.3 5.8e-31 107.7 28.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK36203.2 - 0.0033 15.9 2.9 0.0033 15.9 2.9 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DcpS_C PF11969.8 EDK36204.2 - 1.1e-30 106.4 3.5 1.5e-30 106.0 3.5 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 EDK36204.2 - 6.2e-14 52.5 0.6 1e-13 51.8 0.6 1.3 1 0 0 1 1 1 1 HIT domain zf-C2HE PF16278.5 EDK36204.2 - 1.2e-11 44.9 0.0 2.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 EDK36204.2 - 0.038 14.0 0.1 0.084 12.9 0.1 1.6 1 0 0 1 1 1 0 BED zinc finger Pkr1 PF08636.10 EDK36205.1 - 3.3e-29 100.8 5.3 4e-29 100.6 5.3 1.1 1 0 0 1 1 1 1 ER protein Pkr1 Wzy_C PF04932.15 EDK36205.1 - 0.034 13.8 0.1 0.037 13.7 0.1 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF4834 PF16118.5 EDK36205.1 - 0.068 14.1 0.0 0.092 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) zf-RING_4 PF14570.6 EDK36206.2 - 2.7e-16 59.1 7.3 5.5e-16 58.1 7.3 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EDK36206.2 - 2e-08 33.9 0.0 5.3e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EDK36206.2 - 0.00023 20.9 3.0 0.00023 20.9 3.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 EDK36206.2 - 0.00067 19.6 2.1 0.0018 18.2 2.1 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 EDK36206.2 - 0.013 15.4 3.3 0.028 14.3 3.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDK36206.2 - 0.063 13.2 4.5 0.15 11.9 4.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK36206.2 - 0.26 11.7 4.7 0.56 10.6 4.7 1.6 1 0 0 1 1 1 0 Ring finger domain Anticodon_1 PF08264.13 EDK36207.1 - 1.1e-14 54.6 0.1 2e-14 53.8 0.1 1.4 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.14 EDK36207.1 - 0.079 12.8 8.2 0.36 10.7 8.2 2.0 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS tRNA-synt_1 PF00133.22 EDK36208.2 - 1e-153 512.8 0.2 1.4e-153 512.3 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDK36208.2 - 1.4e-20 73.4 0.3 6.8e-12 44.8 0.0 3.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDK36208.2 - 0.0022 17.5 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDK36208.2 - 0.05 12.9 0.0 3.9 6.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Tic110 PF16940.5 EDK36208.2 - 0.093 11.2 0.1 0.14 10.6 0.1 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Citrate_synt PF00285.21 EDK36209.1 - 2.6e-101 339.3 0.0 3e-101 339.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DSPc PF00782.20 EDK36210.2 - 3.2e-27 94.9 0.0 7.9e-27 93.7 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Zn_ribbon_SprT PF17283.2 EDK36210.2 - 0.0078 16.1 4.4 0.028 14.3 0.1 3.4 3 0 0 3 3 3 1 SprT-like zinc ribbon domain Yippee-Mis18 PF03226.14 EDK36210.2 - 0.011 16.0 1.4 0.15 12.3 1.3 2.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Init_tRNA_PT PF04179.12 EDK36210.2 - 0.014 15.7 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase PF00102.27 EDK36210.2 - 0.018 14.6 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Elf1 PF05129.13 EDK36210.2 - 0.019 15.0 0.2 2.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zf-3CxxC_2 PF17180.4 EDK36210.2 - 0.13 13.1 3.6 0.19 12.5 0.9 2.2 2 0 0 2 2 2 0 Zinc-binding domain zf_UBZ PF18439.1 EDK36210.2 - 0.33 10.6 3.3 13 5.5 0.2 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_4 PF13717.6 EDK36210.2 - 0.52 10.3 4.7 11 6.0 0.5 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Apc15p PF05841.11 EDK36211.2 - 6.9e-15 55.9 4.3 9.1e-15 55.6 0.4 2.5 2 1 0 2 2 2 1 Apc15p protein Gp58 PF07902.11 EDK36211.2 - 0.048 12.0 0.3 0.063 11.6 0.3 1.1 1 0 0 1 1 1 0 gp58-like protein CTU2 PF10288.9 EDK36212.2 - 3.9e-19 69.0 0.1 7.2e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 EDK36212.2 - 0.00017 21.4 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 2 PP-loop family zinc_ribbon_15 PF17032.5 EDK36212.2 - 4.7 8.0 6.0 2.9 8.7 0.3 2.9 3 1 1 4 4 4 0 zinc-ribbon family COX17 PF05051.13 EDK36213.2 - 0.00034 20.9 2.8 0.00056 20.2 2.8 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 EDK36213.2 - 0.0062 16.8 6.1 0.017 15.4 5.5 1.7 1 1 1 2 2 2 1 Cytochrome c oxidase assembly protein PET191 CHCH PF06747.13 EDK36213.2 - 0.016 15.3 3.0 0.025 14.7 3.0 1.4 1 0 0 1 1 1 0 CHCH domain PH PF00169.29 EDK36215.2 - 5.2e-14 52.6 0.1 3.3e-13 50.1 0.0 2.4 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 EDK36215.2 - 1.6e-08 34.0 0.2 3.9e-08 32.8 0.1 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDK36215.2 - 3.4e-08 33.2 0.0 7.4e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 EDK36215.2 - 8.5e-08 32.2 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.6 EDK36215.2 - 8.1e-05 23.0 0.1 0.00071 20.0 0.1 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EDK36215.2 - 0.0015 18.8 0.0 0.0079 16.5 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain SAM_1 PF00536.30 EDK36215.2 - 0.016 15.6 0.1 0.028 14.9 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EDK36215.2 - 0.018 14.7 0.0 0.044 13.5 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain Agenet PF05641.12 EDK36215.2 - 0.096 13.2 0.1 0.27 11.7 0.1 1.8 1 0 0 1 1 1 0 Agenet domain UPF0242 PF06785.11 EDK36215.2 - 2 8.5 12.3 3.2 7.8 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TPR_2 PF07719.17 EDK36216.2 - 3.4e-31 104.8 0.2 5.4e-06 26.1 0.0 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDK36216.2 - 1.2e-30 104.1 1.2 5.9e-06 25.9 0.0 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK36216.2 - 2.4e-28 98.2 9.8 1e-20 73.7 0.8 3.5 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDK36216.2 - 1.9e-27 93.1 0.2 9.5e-05 22.3 0.0 9.0 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36216.2 - 1e-16 61.3 3.0 7e-07 29.8 0.3 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK36216.2 - 2e-16 59.1 1.5 0.13 12.7 0.0 7.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDK36216.2 - 1.4e-14 54.2 0.0 0.0015 18.8 0.0 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDK36216.2 - 9.6e-14 50.8 0.5 0.014 15.1 0.1 7.2 4 2 3 7 7 7 5 TPR repeat TPR_19 PF14559.6 EDK36216.2 - 9.7e-12 45.2 1.8 0.023 15.2 0.7 6.1 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDK36216.2 - 9.2e-11 41.6 0.1 0.015 16.1 0.5 6.8 5 1 2 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDK36216.2 - 2.5e-10 40.3 0.0 0.00024 21.2 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDK36216.2 - 3.5e-09 36.7 0.5 0.057 14.1 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDK36216.2 - 1.2e-08 34.4 0.2 2.6 8.3 0.0 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK36216.2 - 0.012 15.1 0.0 0.057 12.8 0.0 2.2 2 1 1 3 3 3 0 MalT-like TPR region ChAPs PF09295.10 EDK36216.2 - 0.044 12.8 0.0 5.5 5.9 0.0 3.1 2 1 2 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF1039 PF06287.11 EDK36216.2 - 0.087 13.3 0.0 5.6 7.5 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1039) TPR_10 PF13374.6 EDK36216.2 - 0.68 9.9 5.3 1.1 9.3 0.0 4.0 6 0 0 6 6 5 0 Tetratricopeptide repeat EMP70 PF02990.16 EDK36217.2 - 1.4e-143 479.4 8.9 2e-143 478.8 8.9 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 DUF5518 PF17647.1 EDK36217.2 - 0.011 15.9 4.7 0.011 15.9 4.7 5.2 5 0 0 5 5 5 0 Family of unknown function (DUF5518) DUF962 PF06127.11 EDK36217.2 - 0.081 13.0 1.9 1.5 9.0 1.9 3.2 1 1 0 1 1 1 0 Protein of unknown function (DUF962) DUF5305 PF17231.2 EDK36217.2 - 4.8 6.5 8.3 0.67 9.3 0.1 3.1 3 1 1 4 4 4 0 Family of unknown function (DUF5305) ATP-synt PF00231.19 EDK36218.2 - 2.3e-75 253.9 4.2 2.5e-75 253.8 4.2 1.0 1 0 0 1 1 1 1 ATP synthase ATPase_2 PF01637.18 EDK36218.2 - 0.09 12.7 0.4 0.27 11.1 0.3 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Frag1 PF10277.9 EDK36219.2 - 7.9e-41 140.0 14.8 7.9e-41 140.0 14.8 2.9 3 0 0 3 3 3 2 Frag1/DRAM/Sfk1 family FUSC PF04632.12 EDK36219.2 - 0.011 14.4 0.3 0.011 14.4 0.3 2.6 2 1 1 3 3 3 0 Fusaric acid resistance protein family PDZ_1 PF12812.7 EDK36220.2 - 1.6e-47 159.4 0.0 6.9e-33 112.5 0.0 3.0 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 EDK36220.2 - 1.2e-25 91.2 0.1 2e-19 71.0 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_2 PF13180.6 EDK36220.2 - 1.3e-16 60.6 1.1 9e-06 25.9 0.0 4.0 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 EDK36220.2 - 5e-15 55.1 0.1 1.6e-08 34.3 0.1 3.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 EDK36220.2 - 3.4e-14 53.0 0.0 4.4e-07 30.2 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 EDK36220.2 - 9.6e-05 22.3 0.2 0.56 10.2 0.0 3.7 4 0 0 4 4 4 1 Tricorn protease PDZ domain Trypsin PF00089.26 EDK36220.2 - 0.00021 21.2 0.0 0.00093 19.1 0.0 2.0 1 1 0 1 1 1 1 Trypsin PDZ_3 PF17815.1 EDK36220.2 - 0.00033 20.5 0.2 3.8 7.4 0.0 4.3 4 1 1 5 5 5 1 PDZ domain Peptidase_S7 PF00949.21 EDK36220.2 - 0.034 14.0 0.1 0.09 12.6 0.1 1.7 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF31 PF01732.16 EDK36220.2 - 0.035 13.7 0.3 0.084 12.4 0.3 1.6 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.9 EDK36220.2 - 0.074 11.7 0.8 0.18 10.4 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 ETC_C1_NDUFA4 PF04800.12 EDK36221.2 - 4.6e-30 103.7 2.1 6.6e-30 103.2 2.1 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region ORC6 PF05460.13 EDK36222.2 - 5.5e-111 371.3 0.0 6.3e-111 371.1 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) N-SET PF11764.8 EDK36223.2 - 2.5e-49 167.7 1.0 2.5e-49 167.7 1.0 3.2 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EDK36223.2 - 4.2e-23 80.8 2.3 9.2e-23 79.7 2.3 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.28 EDK36223.2 - 4.5e-19 69.4 0.2 4.5e-19 69.4 0.2 3.4 2 1 0 2 2 2 1 SET domain Attachment_P66 PF11263.8 EDK36223.2 - 0.095 11.9 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 DUF3629 PF12302.8 EDK36223.2 - 8.2 5.8 12.0 20 4.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3629) MutS_V PF00488.21 EDK36224.2 - 6.3e-73 244.8 0.3 1.2e-72 243.9 0.3 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDK36224.2 - 4.4e-28 98.8 5.1 5.3e-28 98.6 3.5 2.0 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EDK36224.2 - 3.7e-21 75.5 0.1 3e-20 72.6 0.0 2.4 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EDK36224.2 - 3.8e-11 43.4 0.3 4.9e-10 39.8 0.0 2.4 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.6 EDK36224.2 - 0.098 12.4 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gar1 PF04410.14 EDK36225.2 - 5.1e-45 153.0 0.1 5.1e-45 153.0 0.1 2.6 2 1 1 3 3 3 1 Gar1/Naf1 RNA binding region Drf_FH1 PF06346.12 EDK36225.2 - 0.89 9.3 18.1 1.4 8.7 16.8 2.1 2 0 0 2 2 2 0 Formin Homology Region 1 SUN PF03856.13 EDK36226.2 - 9.2e-97 323.3 15.3 1.5e-96 322.6 15.3 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) MSA-2c PF12238.8 EDK36226.2 - 0.47 10.4 4.8 0.65 10.0 4.8 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF1180 PF06679.12 EDK36226.2 - 2.7 8.4 11.2 5.7 7.3 11.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Macoilin PF09726.9 EDK36226.2 - 3.9 5.9 4.3 4.9 5.6 4.3 1.1 1 0 0 1 1 1 0 Macoilin family AA_permease PF00324.21 EDK36227.1 - 1.6e-122 409.5 47.0 1.9e-122 409.3 47.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK36227.1 - 1.6e-30 106.3 50.2 1.9e-30 106.0 49.8 1.3 1 1 0 1 1 1 1 Amino acid permease Reoviridae_Vp9 PF08978.10 EDK36227.1 - 0.039 13.1 0.1 0.11 11.6 0.1 1.7 1 0 0 1 1 1 0 Reoviridae VP9 DUF5493 PF17597.2 EDK36227.1 - 2.7 8.3 17.0 4.5 7.6 0.4 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5493) Eaf7 PF07904.13 EDK36229.2 - 2.9e-15 56.5 7.1 2.9e-15 56.5 7.1 2.5 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 TFIIF_alpha PF05793.12 EDK36229.2 - 0.011 14.4 41.4 0.013 14.1 41.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) S4 PF01479.25 EDK36230.1 - 1.7e-13 50.0 0.0 3.8e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 S4 domain MTS PF05175.14 EDK36231.2 - 2e-10 40.5 0.0 3.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EDK36231.2 - 3.3e-08 33.5 0.0 4.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36231.2 - 3.6e-06 27.6 0.0 7.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 EDK36231.2 - 0.00022 20.6 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_15 PF09445.10 EDK36231.2 - 0.0003 20.4 0.1 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 EDK36231.2 - 0.00072 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDK36231.2 - 0.00095 18.6 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 EDK36231.2 - 0.0015 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 AviRa PF11599.8 EDK36231.2 - 0.0016 18.0 0.1 0.0048 16.4 0.1 1.7 1 1 1 2 2 2 1 RRNA methyltransferase AviRa Methyltransf_16 PF10294.9 EDK36231.2 - 0.0036 17.1 0.0 0.0072 16.1 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 EDK36231.2 - 0.0046 16.3 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDK36231.2 - 0.0049 16.7 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDK36231.2 - 0.0058 16.6 0.0 0.0086 16.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36231.2 - 0.012 16.4 0.0 0.026 15.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 EDK36231.2 - 0.013 15.2 0.0 0.045 13.4 0.0 1.9 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 HTH_Mga PF08280.11 EDK36231.2 - 0.016 15.2 0.1 0.074 13.1 0.0 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain PrmC_N PF17827.1 EDK36231.2 - 0.031 14.9 0.0 0.065 13.8 0.0 1.6 1 0 0 1 1 1 0 PrmC N-terminal domain Met_10 PF02475.16 EDK36231.2 - 0.038 13.7 0.0 0.095 12.4 0.0 1.6 2 0 0 2 2 2 0 Met-10+ like-protein Methyltransf_11 PF08241.12 EDK36231.2 - 0.055 14.1 0.0 0.16 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 EDK36231.2 - 0.073 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 MraW methylase family Methyltransf_4 PF02390.17 EDK36231.2 - 0.076 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltr_RsmB-F PF01189.17 EDK36232.2 - 8e-82 273.7 0.0 2.4e-81 272.2 0.0 1.9 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EDK36232.2 - 3e-08 34.0 0.0 9.7e-08 32.4 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EDK36232.2 - 0.028 14.6 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase RBM39linker PF15519.6 EDK36232.2 - 1.9 9.6 7.9 0.21 12.7 1.6 2.6 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Gcd10p PF04189.13 EDK36233.2 - 6.9e-99 330.7 0.1 8.5e-99 330.4 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family AvrM_N PF18247.1 EDK36233.2 - 0.004 17.1 0.3 0.012 15.6 0.3 1.8 1 0 0 1 1 1 1 Flax-rust effector AvrM N-terminal domain CAP_N PF01213.19 EDK36234.2 - 1.1e-109 366.8 4.5 1.1e-109 366.8 4.5 1.5 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EDK36234.2 - 1.5e-55 187.1 4.3 2.2e-55 186.6 4.3 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Actin PF00022.19 EDK36235.2 - 7.6e-50 169.7 0.0 1.5e-28 99.6 0.0 2.4 2 1 0 2 2 2 2 Actin DnaJ_C PF01556.18 EDK36236.2 - 1.2e-43 148.7 0.1 1.7e-43 148.2 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDK36236.2 - 8.4e-27 93.1 2.7 1.4e-26 92.4 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDK36236.2 - 2.2e-14 53.5 21.1 3.9e-14 52.8 21.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDK36236.2 - 2.6 8.1 17.5 0.79 9.7 5.2 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein MFS_1 PF07690.16 EDK36237.2 - 6.5e-40 137.1 26.9 6.5e-40 137.1 26.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GLTP PF08718.11 EDK36238.2 - 0.0043 17.3 0.4 0.007 16.6 0.4 1.4 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PRK PF00485.18 EDK36239.2 - 9.5e-09 35.3 0.1 3.9e-08 33.3 0.1 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EDK36239.2 - 0.00083 19.9 0.0 0.0022 18.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDK36239.2 - 0.015 15.7 0.0 0.021 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain CPT PF07931.12 EDK36239.2 - 0.063 13.1 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EDK36239.2 - 0.11 12.7 0.0 0.66 10.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EDK36239.2 - 0.13 12.0 0.2 0.55 9.9 0.1 2.0 2 0 0 2 2 2 0 Cytidylate kinase GNAT_acetyltr_2 PF13718.6 EDK36240.1 - 2.2e-102 341.3 0.0 1.6e-101 338.4 0.0 2.3 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EDK36240.1 - 9.3e-91 303.7 4.2 2.1e-90 302.6 4.2 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EDK36240.1 - 1.7e-65 220.1 0.0 1.1e-64 217.6 0.0 2.3 3 0 0 3 3 3 1 Helicase DUF1726 PF08351.11 EDK36240.1 - 1.4e-34 117.8 0.3 1.1e-33 115.0 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 EDK36240.1 - 0.0018 18.5 0.0 0.34 11.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK36240.1 - 0.0049 16.6 0.0 0.23 11.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Acetyltransf_7 PF13508.7 EDK36240.1 - 0.024 15.0 0.0 0.31 11.5 0.0 2.9 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain DEAD PF00270.29 EDK36240.1 - 0.025 14.4 0.0 0.062 13.1 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase Acetyltransf_1 PF00583.25 EDK36240.1 - 0.094 12.9 0.0 0.86 9.9 0.0 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family NDT80_PhoG PF05224.12 EDK36241.2 - 3.9e-38 131.5 0.0 7.2e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family LSM PF01423.22 EDK36242.2 - 1.8e-18 66.0 0.6 2.5e-18 65.5 0.6 1.2 1 0 0 1 1 1 1 LSM domain DUF1461 PF07314.11 EDK36242.2 - 0.04 13.8 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) SM-ATX PF14438.6 EDK36242.2 - 0.1 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain zf-C2H2_10 PF16588.5 EDK36243.2 - 2.6e-11 43.0 5.4 2.6e-11 43.0 5.4 2.1 2 0 0 2 2 2 1 C2H2 zinc-finger Peptidase_C6 PF00851.18 EDK36243.2 - 0.0015 17.6 0.8 0.002 17.1 0.8 1.1 1 0 0 1 1 1 1 Helper component proteinase AAA_9 PF12781.7 EDK36243.2 - 0.0018 17.5 2.2 0.003 16.7 2.2 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region zf-HC5HC2H_2 PF13832.6 EDK36243.2 - 0.026 14.7 2.1 0.68 10.1 0.4 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain C1_1 PF00130.22 EDK36243.2 - 0.031 14.2 3.1 0.83 9.6 0.6 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) XH PF03469.14 EDK36243.2 - 0.074 13.0 1.1 0.13 12.1 0.3 1.9 1 1 0 1 1 1 0 XH domain HIP1_clath_bdg PF16515.5 EDK36243.2 - 0.13 12.9 0.4 0.13 12.9 0.4 2.2 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cytochrome_C554 PF13435.6 EDK36243.2 - 0.16 12.9 8.7 1 10.3 2.9 2.5 1 1 0 2 2 2 0 Cytochrome c554 and c-prime SlyX PF04102.12 EDK36243.2 - 0.21 12.3 1.7 0.5 11.0 0.2 2.5 2 1 0 2 2 2 0 SlyX DUF948 PF06103.11 EDK36243.2 - 0.28 11.5 1.0 0.7 10.2 0.2 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HypA PF01155.19 EDK36243.2 - 0.76 9.8 4.9 2.8 8.0 4.9 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rft-1 PF04506.13 EDK36244.2 - 2.3e-94 317.0 7.9 3e-94 316.6 7.9 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 EDK36244.2 - 0.00025 20.5 6.1 0.00025 20.5 6.1 2.5 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein CBFD_NFYB_HMF PF00808.23 EDK36245.2 - 1.4e-26 92.5 0.0 2.3e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK36245.2 - 7.8e-06 26.3 1.1 2.2e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EDK36245.2 - 0.019 15.1 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EDK36245.2 - 0.034 14.1 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-18kDa PF02269.16 EDK36245.2 - 0.037 14.0 0.0 0.072 13.1 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit MAGI_u5 PF16666.5 EDK36245.2 - 0.061 13.5 0.9 0.11 12.7 0.2 1.8 2 0 0 2 2 2 0 Unstructured region on MAGI PAN_3 PF08277.12 EDK36245.2 - 0.11 12.3 0.2 0.28 11.0 0.2 1.6 1 0 0 1 1 1 0 PAN-like domain zf-RING_2 PF13639.6 EDK36246.2 - 3.9e-09 36.7 10.7 3.9e-09 36.7 10.7 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK36246.2 - 2.4e-08 33.7 11.1 5.6e-08 32.5 11.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDK36246.2 - 7.4e-08 32.6 9.1 1.9e-07 31.3 9.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK36246.2 - 1.7e-07 31.0 12.1 3.9e-07 29.8 12.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK36246.2 - 2e-05 24.5 4.4 2e-05 24.5 4.4 2.3 2 1 1 3 3 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDK36246.2 - 2.6e-05 24.1 10.6 2.6e-05 24.1 10.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 EDK36246.2 - 5.5e-05 22.8 6.8 5.5e-05 22.8 6.8 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EDK36246.2 - 0.0016 18.2 7.1 0.0016 18.2 7.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDK36246.2 - 0.0019 18.2 3.2 0.0054 16.8 3.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.6 EDK36246.2 - 0.07 13.4 5.7 0.039 14.2 3.4 1.8 2 0 0 2 2 1 0 PHD-like zinc-binding domain zf-RING_4 PF14570.6 EDK36246.2 - 0.33 10.8 8.4 0.74 9.7 8.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDK36246.2 - 0.62 10.3 10.9 2.1 8.6 10.9 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3H2C3 PF17122.5 EDK36246.2 - 1 9.4 10.0 3.2 7.8 10.0 1.9 1 0 0 1 1 1 0 Zinc-finger zf-RING_6 PF14835.6 EDK36246.2 - 1.2 9.1 4.6 3 7.8 4.6 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Cortexin PF11057.8 EDK36246.2 - 1.6 8.6 10.1 2.1 8.2 0.0 3.9 4 0 0 4 4 4 0 Cortexin of kidney zf-C3HC4_4 PF15227.6 EDK36246.2 - 2 8.7 8.5 6.8 6.9 8.5 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EDK36246.2 - 2.1 8.5 10.9 5.2 7.3 10.9 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 EDK36246.2 - 3.4 8.1 11.4 8.1 6.8 11.4 1.7 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.5 EDK36246.2 - 4.5 7.0 10.4 1.6 8.4 7.5 1.8 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type Methyltr_RsmB-F PF01189.17 EDK36247.2 - 3.7e-39 134.5 0.0 2.4e-38 131.8 0.0 2.2 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDK36247.2 - 0.00036 20.7 0.0 0.0007 19.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF1887 PF09002.11 EDK36247.2 - 0.029 13.1 0.1 0.12 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1887) Lon_C PF05362.13 EDK36248.2 - 7.1e-65 218.4 0.0 1.4e-64 217.4 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EDK36248.2 - 4.5e-31 108.3 1.5 5.5e-31 108.1 0.0 2.0 2 0 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EDK36248.2 - 1.1e-20 74.4 0.2 3.6e-20 72.7 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK36248.2 - 3.5e-07 30.3 0.0 1.1e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 EDK36248.2 - 8.9e-06 24.8 0.0 2.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 EDK36248.2 - 4.3e-05 23.3 0.0 0.0017 18.1 0.0 2.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDK36248.2 - 0.0001 22.7 0.0 0.00033 21.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDK36248.2 - 0.00025 21.3 0.1 0.027 14.8 0.0 2.6 1 1 0 2 2 2 1 AAA domain ChlI PF13541.6 EDK36248.2 - 0.00045 20.1 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase TIP49 PF06068.13 EDK36248.2 - 0.0011 18.2 0.1 0.0024 17.1 0.1 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EDK36248.2 - 0.0015 18.3 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EDK36248.2 - 0.0023 18.5 0.0 0.01 16.4 0.0 2.2 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDK36248.2 - 0.0045 16.9 0.0 0.11 12.4 0.0 2.5 1 1 1 2 2 2 1 NTPase Zeta_toxin PF06414.12 EDK36248.2 - 0.012 14.9 1.0 0.022 14.0 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_3 PF07726.11 EDK36248.2 - 0.014 15.3 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDK36248.2 - 0.018 14.8 0.1 0.051 13.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 EDK36248.2 - 0.018 14.4 0.4 0.46 9.8 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDK36248.2 - 0.026 14.5 0.3 0.077 13.0 0.0 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EDK36248.2 - 0.028 14.5 0.2 0.088 12.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 EDK36248.2 - 0.037 14.2 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDK36248.2 - 0.055 13.8 3.2 0.16 12.3 0.1 2.6 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EDK36248.2 - 0.09 13.2 0.0 0.31 11.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EDK36248.2 - 0.11 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EDK36248.2 - 0.11 12.1 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EDK36248.2 - 0.54 10.0 0.0 0.54 10.0 0.0 3.5 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EDK36248.2 - 0.56 10.7 0.0 0.56 10.7 0.0 2.6 3 0 0 3 3 2 0 ABC transporter Cytidylate_kin2 PF13189.6 EDK36248.2 - 3.2 7.8 8.3 41 4.2 1.0 3.6 3 1 1 4 4 4 0 Cytidylate kinase-like family zf-UBR PF02207.20 EDK36249.2 - 4.8e-15 55.5 8.7 4.8e-15 55.5 8.7 2.0 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) AEP1 PF17049.5 EDK36249.2 - 0.14 11.3 0.1 0.2 10.7 0.1 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 zf_C2H2_ZHX PF18387.1 EDK36249.2 - 1.3 8.8 5.8 13 5.5 0.1 3.2 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain MCM PF00493.23 EDK36250.2 - 1.4e-99 331.8 0.0 2.1e-99 331.2 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM2_N PF12619.8 EDK36250.2 - 5.9e-39 133.8 36.9 5.9e-39 133.8 36.9 2.9 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_OB PF17207.3 EDK36250.2 - 4.6e-37 126.7 0.0 8.5e-37 125.8 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDK36250.2 - 7.1e-26 90.5 0.2 1.9e-25 89.1 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDK36250.2 - 9.8e-11 42.2 0.1 9.8e-11 42.2 0.1 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDK36250.2 - 2.1e-08 33.8 0.0 3.7e-06 26.5 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDK36250.2 - 5.7e-07 29.6 0.0 2.5e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDK36250.2 - 0.00059 19.7 0.0 0.012 15.4 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDK36250.2 - 0.0019 18.0 0.1 0.01 15.6 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Metallophos PF00149.28 EDK36251.2 - 0.018 15.6 0.0 0.029 14.9 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase KRE1 PF17056.5 EDK36253.1 - 1.1e-26 92.4 11.7 1.5e-26 91.9 11.7 1.2 1 0 0 1 1 1 1 Killer toxin-resistance protein 1 DUF624 PF04854.14 EDK36253.1 - 0.0067 16.5 1.2 0.013 15.6 1.2 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF624 Hyr1 PF15789.5 EDK36253.1 - 0.0067 16.0 1.0 0.0067 16.0 1.0 2.0 1 1 1 2 2 2 1 Hyphally regulated cell wall GPI-anchored protein 1 Methyltransf_16 PF10294.9 EDK36254.1 - 6.6e-17 61.8 0.0 1.1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EDK36254.1 - 2.3e-06 27.5 0.0 3.4e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3883 PF13020.6 EDK36254.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) Methyltransf_11 PF08241.12 EDK36254.1 - 0.025 15.2 0.0 0.04 14.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36254.1 - 0.057 13.2 0.6 0.12 12.2 0.6 1.6 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EDK36254.1 - 0.094 12.3 0.1 0.37 10.3 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 EDK36254.1 - 0.15 12.8 0.0 0.32 11.7 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Proteasom_PSMB PF10508.9 EDK36255.2 - 0.11 11.0 0.0 0.2 10.1 0.0 1.4 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Glyco_hydro_125 PF06824.11 EDK36256.2 - 3.1e-172 573.1 0.0 3.8e-172 572.9 0.0 1.1 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) ATP_bind_1 PF03029.17 EDK36257.2 - 1.9e-79 266.9 0.1 1.9e-79 266.9 0.1 1.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EDK36257.2 - 6.8e-08 32.3 0.1 2.3e-05 24.1 0.1 3.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EDK36257.2 - 1.2e-05 25.4 0.0 2.9e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EDK36257.2 - 1.7e-05 23.9 0.1 0.023 13.7 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EDK36257.2 - 9.5e-05 22.2 0.7 0.00042 20.1 0.0 2.2 2 1 1 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EDK36257.2 - 0.00014 21.9 0.1 0.0027 17.7 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK36257.2 - 0.00027 20.9 0.0 1.5 8.7 0.0 3.4 3 0 0 3 3 3 2 RsgA GTPase PduV-EutP PF10662.9 EDK36257.2 - 0.0003 20.6 0.1 0.027 14.2 0.0 2.8 3 1 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EDK36257.2 - 0.00084 19.6 0.1 0.0038 17.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EDK36257.2 - 0.0011 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain FeoB_N PF02421.18 EDK36257.2 - 0.0015 18.1 0.0 0.096 12.2 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B Arf PF00025.21 EDK36257.2 - 0.0018 17.8 0.0 0.92 8.9 0.0 3.2 2 1 0 2 2 2 1 ADP-ribosylation factor family SRP54 PF00448.22 EDK36257.2 - 0.0039 16.8 0.0 0.035 13.7 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EDK36257.2 - 0.0071 16.7 0.1 0.019 15.3 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EDK36257.2 - 0.0098 16.1 0.1 0.96 9.7 0.0 2.8 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDK36257.2 - 0.011 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region CLP1_P PF16575.5 EDK36257.2 - 0.012 15.4 0.0 2.7 7.8 0.0 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRPRB PF09439.10 EDK36257.2 - 0.012 15.1 2.5 0.24 10.8 0.0 2.6 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 EDK36257.2 - 0.015 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK36257.2 - 0.016 14.6 0.2 0.75 9.1 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 EDK36257.2 - 0.016 14.8 0.3 0.12 11.9 0.3 2.2 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.18 EDK36257.2 - 0.019 14.7 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EDK36257.2 - 0.02 15.4 1.7 0.051 14.1 0.0 2.4 2 1 1 3 3 3 0 AAA domain NB-ARC PF00931.22 EDK36257.2 - 0.024 13.8 0.2 0.077 12.2 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.14 EDK36257.2 - 0.17 11.8 0.4 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_E PF05680.12 EDK36257.2 - 0.46 10.9 5.1 0.21 11.9 2.2 1.9 2 0 0 2 2 1 0 ATP synthase E chain DUF87 PF01935.17 EDK36257.2 - 0.67 10.0 4.0 3.1 7.8 0.0 2.5 2 1 1 3 3 3 0 Helicase HerA, central domain EMC3_TMCO1 PF01956.16 EDK36258.1 - 2.6e-51 173.7 0.5 3.1e-51 173.5 0.5 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like DUF3767 PF12597.8 EDK36259.1 - 1.2e-37 127.7 0.5 2e-37 127.1 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) CPP1-like PF11833.8 EDK36259.1 - 8.6 6.0 8.2 0.7 9.5 0.1 2.2 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like AAA PF00004.29 EDK36260.2 - 2.4e-59 199.5 0.0 5.2e-43 146.6 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EDK36260.2 - 1.6e-24 86.1 1.8 2.2e-24 85.7 0.2 2.2 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.6 EDK36260.2 - 4e-11 43.6 4.1 8.6e-05 23.0 0.1 4.1 2 2 2 4 4 4 2 AAA ATPase domain AAA_lid_3 PF17862.1 EDK36260.2 - 2e-08 33.9 0.3 2.8e-05 23.8 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain NACHT PF05729.12 EDK36260.2 - 2.6e-06 27.4 5.1 0.00073 19.5 1.2 3.7 3 1 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 EDK36260.2 - 5.2e-06 26.8 3.8 0.14 12.4 0.9 4.3 2 2 1 3 3 3 2 AAA domain ABC_tran PF00005.27 EDK36260.2 - 2.3e-05 24.9 2.6 0.0039 17.7 0.2 3.1 3 0 0 3 3 2 1 ABC transporter AAA_25 PF13481.6 EDK36260.2 - 3.3e-05 23.5 1.7 0.59 9.7 0.2 4.0 2 2 2 4 4 4 1 AAA domain AAA_14 PF13173.6 EDK36260.2 - 4e-05 23.7 0.0 0.16 12.0 0.1 2.7 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EDK36260.2 - 4.8e-05 23.3 0.1 0.002 18.0 0.2 2.6 2 1 0 2 2 2 1 Bacterial dnaA protein IstB_IS21 PF01695.17 EDK36260.2 - 6.2e-05 22.8 0.2 0.12 12.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_2 PF07724.14 EDK36260.2 - 8e-05 22.8 0.0 0.011 15.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.6 EDK36260.2 - 8.5e-05 22.3 0.0 0.00079 19.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK36260.2 - 0.00016 22.0 0.0 0.7 10.3 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_18 PF13238.6 EDK36260.2 - 0.00017 22.2 0.3 0.52 10.9 0.0 3.6 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EDK36260.2 - 0.00043 20.3 0.0 1.6 8.7 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK36260.2 - 0.0014 18.8 0.0 0.084 13.0 0.0 3.0 3 1 0 3 3 2 1 AAA domain RuvB_N PF05496.12 EDK36260.2 - 0.0024 17.6 0.0 0.033 14.0 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EDK36260.2 - 0.0028 17.4 1.7 4.1 7.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EDK36260.2 - 0.0035 17.1 0.1 0.86 9.3 0.0 3.0 2 1 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.9 EDK36260.2 - 0.006 15.9 0.0 1.9 7.6 0.0 2.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EDK36260.2 - 0.0085 15.6 0.0 1.2 8.6 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region ATPase PF06745.13 EDK36260.2 - 0.012 15.0 0.1 4.4 6.6 0.0 2.5 2 0 0 2 2 2 0 KaiC TsaE PF02367.17 EDK36260.2 - 0.014 15.4 0.1 1.8 8.5 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PEX-2N PF09263.10 EDK36260.2 - 0.016 15.5 0.0 0.063 13.6 0.0 2.1 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal Zeta_toxin PF06414.12 EDK36260.2 - 0.02 14.2 0.1 5.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 EDK36260.2 - 0.032 14.0 0.1 0.77 9.5 0.0 2.8 3 0 0 3 3 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 EDK36260.2 - 0.035 13.8 0.5 1.7 8.3 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EDK36260.2 - 0.06 12.7 0.2 0.77 9.1 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDK36260.2 - 0.098 11.8 0.1 0.65 9.1 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_17 PF13207.6 EDK36260.2 - 0.12 12.8 0.0 2.9 8.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain Torsin PF06309.11 EDK36260.2 - 0.15 12.2 0.2 8 6.6 0.0 3.5 4 0 0 4 4 3 0 Torsin Sld5 PF05916.11 EDK36261.2 - 2.2e-15 57.0 1.6 3.4e-15 56.5 1.6 1.3 1 0 0 1 1 1 1 GINS complex protein AAA_34 PF13872.6 EDK36261.2 - 0.019 13.9 0.3 0.026 13.4 0.3 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Med11 PF10280.9 EDK36262.2 - 1.1e-18 68.0 0.4 1.4e-18 67.7 0.4 1.1 1 0 0 1 1 1 1 Mediator complex protein Mur_ligase_M PF08245.12 EDK36263.2 - 2.1e-06 27.9 0.5 1.8e-05 24.9 0.1 2.5 2 1 1 3 3 3 1 Mur ligase middle domain WD40 PF00400.32 EDK36264.2 - 1.1e-06 29.2 5.3 0.37 11.7 1.5 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EDK36264.2 - 2.2 8.9 7.0 1.1 9.8 0.1 3.6 3 1 1 4 4 4 0 PQQ-like domain WD40 PF00400.32 EDK36265.1 - 1.4e-28 98.5 14.7 3.4e-08 34.0 0.3 4.7 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 EDK36265.1 - 8e-08 31.4 1.4 0.0035 16.0 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 KOW PF00467.29 EDK36265.1 - 0.013 15.4 0.1 0.36 10.9 0.0 2.7 2 1 0 2 2 2 0 KOW motif DUF3694 PF12473.8 EDK36265.1 - 0.13 12.9 0.7 1.9 9.2 0.1 2.1 2 0 0 2 2 2 0 Kinesin protein Polysacc_synt_2 PF02719.15 EDK36265.1 - 0.14 11.2 0.0 0.28 10.3 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein UPF0052 PF01933.18 EDK36266.2 - 2.4e-59 201.0 0.0 3.3e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Saf_2TM PF18303.1 EDK36266.2 - 0.038 13.6 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain IF-2B PF01008.17 EDK36267.2 - 2.3e-68 230.4 0.0 3.2e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sin_N PF04801.13 EDK36268.2 - 2.9e-23 82.8 0.1 5.1e-23 82.0 0.1 1.3 1 1 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.29 EDK36269.2 - 3.2e-44 150.8 0.4 5.3e-44 150.1 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EDK36269.2 - 2.1e-21 75.9 0.1 1.5e-20 73.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EDK36269.2 - 5.8e-17 62.0 0.0 2.6e-16 60.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK36269.2 - 5.7e-09 36.2 0.0 2.1e-08 34.4 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DcpS_C PF11969.8 EDK36270.2 - 3.1e-34 117.9 0.0 6.2e-34 116.9 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 EDK36270.2 - 3.9e-31 108.0 0.0 6.3e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal TMEM37 PF15108.6 EDK36270.2 - 0.021 14.7 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family HIT PF01230.23 EDK36270.2 - 0.074 13.8 0.7 0.19 12.5 0.2 1.9 2 0 0 2 2 2 0 HIT domain MMM1 PF10296.9 EDK36271.2 - 1.3e-10 40.9 0.6 6.8e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 MFS_1 PF07690.16 EDK36272.1 - 1.7e-34 119.3 23.9 2.4e-34 118.8 23.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK36272.1 - 1.1e-05 24.9 7.8 1.1e-05 24.9 7.8 2.2 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB ERGIC_N PF13850.6 EDK36272.1 - 0.0036 17.6 0.3 3.7 7.9 0.0 3.3 3 0 0 3 3 3 2 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) GFO_IDH_MocA PF01408.22 EDK36273.2 - 6.9e-21 75.3 0.3 1e-20 74.8 0.3 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDK36273.2 - 1.2e-12 47.9 0.0 2.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 EDK36273.2 - 0.011 16.1 0.0 0.019 15.4 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain L51_S25_CI-B8 PF05047.16 EDK36274.2 - 1.9e-10 40.5 0.0 2.4e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain IF2_N PF04760.15 EDK36274.2 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region zf-XS PF03470.14 EDK36274.2 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 XS zinc finger domain LigB PF02900.18 EDK36275.2 - 9.7e-26 90.4 0.0 1.5e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF1682 PF07946.14 EDK36276.2 - 0.78 8.9 23.9 1.3 8.2 23.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) BTB PF00651.31 EDK36277.2 - 3.9e-20 72.1 0.5 1.6e-09 38.0 0.1 2.8 2 1 0 2 2 2 2 BTB/POZ domain Ank PF00023.30 EDK36277.2 - 0.00017 21.9 0.0 0.00072 19.9 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EDK36277.2 - 0.00017 22.0 0.0 0.001 19.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK36277.2 - 0.00029 21.1 0.0 0.00072 19.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDK36277.2 - 0.0014 19.2 0.0 0.0038 17.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDK36277.2 - 0.059 13.9 0.0 0.37 11.5 0.0 2.5 1 0 0 1 1 1 0 Ankyrin repeat Sen15 PF09631.10 EDK36277.2 - 0.12 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Sen15 protein NUC173 PF08161.12 EDK36278.2 - 3.4e-75 252.2 3.1 6.2e-71 238.3 0.1 3.3 3 1 1 4 4 4 2 NUC173 domain Ipi1_N PF12333.8 EDK36278.2 - 0.00023 21.7 0.8 4.7 7.9 0.0 4.3 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation GIT1_C PF12205.8 EDK36278.2 - 0.045 13.9 0.1 9.4 6.4 0.1 3.0 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term HEAT PF02985.22 EDK36278.2 - 0.052 13.8 0.1 16 6.1 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat W2 PF02020.18 EDK36278.2 - 0.077 13.1 1.0 0.5 10.5 0.1 2.8 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon DUF2913 PF11140.8 EDK36278.2 - 0.12 12.1 1.9 13 5.5 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) Pinin_SDK_N PF04697.13 EDK36278.2 - 2.2 8.9 8.6 0.32 11.6 3.7 2.1 2 0 0 2 2 2 0 pinin/SDK conserved region Ribosomal_S16 PF00886.19 EDK36279.1 - 3.4e-24 84.7 0.0 4.8e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 ApoB100_C PF12491.8 EDK36280.2 - 0.081 12.9 1.1 0.18 11.8 0.2 2.0 2 0 0 2 2 2 0 Apolipoprotein B100 C terminal Ribosomal_L10 PF00466.20 EDK36282.1 - 2.1e-25 88.7 0.1 5e-25 87.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EDK36282.1 - 5.2e-22 77.6 0.0 8.7e-22 76.9 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EDK36282.1 - 2.7e-20 72.7 5.6 2.7e-20 72.7 5.6 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein Metallophos PF00149.28 EDK36283.2 - 1.1e-07 32.5 1.3 3.1e-07 31.1 1.3 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Homeodomain PF00046.29 EDK36284.2 - 2.2e-15 56.2 4.1 3.8e-15 55.5 4.1 1.4 1 0 0 1 1 1 1 Homeodomain Ribosomal_S13 PF00416.22 EDK36285.1 - 2.7e-55 186.2 2.8 3.2e-55 186.0 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EDK36285.1 - 0.0026 16.6 0.0 0.0028 16.5 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3196 PF11428.8 EDK36285.1 - 0.056 13.0 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3196) Ribosomal_L4 PF00573.22 EDK36286.1 - 6.5e-49 166.2 0.0 7.6e-49 166.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Peptidase_S10 PF00450.22 EDK36287.2 - 3.6e-104 349.5 0.0 5e-104 349.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase NmrA PF05368.13 EDK36288.2 - 7.1e-54 182.8 0.1 9e-54 182.5 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDK36288.2 - 3.1e-14 53.3 0.0 4.7e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EDK36288.2 - 7.5e-06 25.1 0.0 1.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EDK36288.2 - 0.023 14.9 0.0 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AtuA PF07287.11 EDK36288.2 - 0.071 11.8 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Sugar_tr PF00083.24 EDK36289.1 - 1.7e-86 290.9 21.3 2e-86 290.7 21.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK36289.1 - 8.8e-24 84.1 23.8 4.4e-20 71.9 14.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK36289.1 - 0.00034 19.2 2.6 0.00034 19.2 2.6 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cellulase PF00150.18 EDK36290.1 - 4.9e-32 111.5 1.6 9.6e-32 110.5 1.6 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Phosphorylase PF00343.20 EDK36292.2 - 4.9e-298 990.4 0.0 5.7e-298 990.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF3437 PF11919.8 EDK36292.2 - 0.16 11.9 0.3 0.6 10.1 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) WD40 PF00400.32 EDK36294.2 - 5.2e-11 42.9 12.1 0.087 13.7 0.0 6.1 6 1 0 6 6 6 4 WD domain, G-beta repeat WD40_like PF17005.5 EDK36294.2 - 0.00061 19.2 0.0 0.004 16.5 0.0 2.1 1 1 1 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 EDK36294.2 - 0.035 14.6 1.1 32 5.2 0.1 4.1 4 0 0 4 4 4 0 PQQ-like domain PWWP PF00855.17 EDK36295.2 - 1.1e-22 80.2 0.1 1.1e-22 80.2 0.1 3.0 4 0 0 4 4 4 1 PWWP domain MAGE PF01454.19 EDK36295.2 - 7.1 6.3 16.1 0.99 9.1 4.1 2.9 2 1 0 3 3 3 0 MAGE family DUF4446 PF14584.6 EDK36296.2 - 0.017 15.1 0.1 0.045 13.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Sen15 PF09631.10 EDK36296.2 - 0.038 14.3 0.5 0.27 11.6 0.0 2.4 3 0 0 3 3 3 0 Sen15 protein DUF2207 PF09972.9 EDK36296.2 - 7.5 5.2 13.9 6.9 5.3 2.8 2.1 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) SRF-TF PF00319.18 EDK36297.2 - 4e-21 74.2 0.1 5.7e-21 73.8 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PSP1 PF04468.12 EDK36298.2 - 1.4e-33 115.0 0.2 2.7e-33 114.1 0.2 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF3446 PF11928.8 EDK36298.2 - 7.2 7.0 9.9 2.4 8.5 4.9 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain bZIP_2 PF07716.15 EDK36299.1 - 9e-11 41.7 10.1 9e-11 41.7 10.1 1.6 2 0 0 2 2 2 1 Basic region leucine zipper TSC22 PF01166.18 EDK36299.1 - 0.073 13.4 2.6 0.13 12.6 2.6 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF3450 PF11932.8 EDK36299.1 - 0.084 12.2 7.1 0.11 11.8 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 EDK36299.1 - 0.097 12.8 13.3 0.2 11.8 13.3 1.6 1 0 0 1 1 1 0 bZIP transcription factor DUF1465 PF07323.12 EDK36299.1 - 0.11 12.4 4.1 0.16 11.8 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) YabA PF06156.13 EDK36299.1 - 0.19 12.4 6.3 0.29 11.8 6.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA DUF4094 PF13334.6 EDK36299.1 - 0.28 11.6 7.0 0.19 12.2 5.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Pkinase PF00069.25 EDK36300.2 - 1.2e-62 211.6 0.0 4.7e-39 134.3 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36300.2 - 6.8e-29 100.9 0.1 5.8e-22 78.2 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EDK36300.2 - 1.1e-08 35.3 0.0 2.5e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EDK36300.2 - 2.5e-05 23.7 0.1 0.00061 19.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDK36300.2 - 0.00027 20.9 0.1 0.0042 17.0 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDK36300.2 - 0.0029 17.0 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDK36300.2 - 0.0075 15.4 0.0 0.017 14.2 0.0 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 BamHI PF02923.15 EDK36300.2 - 0.013 15.2 0.1 0.036 13.8 0.1 1.7 2 0 0 2 2 2 0 Restriction endonuclease BamHI GlutR_dimer PF00745.20 EDK36300.2 - 0.024 15.1 3.6 0.078 13.4 3.6 1.9 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain PAS PF00989.25 EDK36300.2 - 0.092 12.8 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 PAS fold RNase_T PF00929.24 EDK36301.1 - 4.7e-32 111.8 0.2 6.6e-32 111.3 0.2 1.2 1 0 0 1 1 1 1 Exonuclease DUF2781 PF10914.8 EDK36302.2 - 3.4e-43 147.6 13.3 3.9e-43 147.4 13.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Miga PF10265.9 EDK36303.2 - 0.011 14.8 4.7 0.013 14.6 4.7 1.2 1 0 0 1 1 1 0 Mitoguardin Plus-3 PF03126.18 EDK36304.2 - 5.3e-26 91.3 0.6 1.5e-25 89.9 0.0 2.1 2 0 0 2 2 2 1 Plus-3 domain Ribosomal_S28e PF01200.18 EDK36306.1 - 8.2e-33 112.2 1.9 9.4e-33 112.0 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Abhydrolase_1 PF00561.20 EDK36307.2 - 9.8e-22 77.8 0.2 2.8e-21 76.3 0.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK36307.2 - 1e-13 52.4 0.0 2.1e-13 51.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK36307.2 - 1.2e-13 50.9 0.0 4.8e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF915 PF06028.11 EDK36307.2 - 0.0011 18.3 0.0 0.0028 17.0 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.7 EDK36307.2 - 0.0013 17.7 0.0 0.0021 17.0 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 EDK36307.2 - 0.0046 16.8 0.0 0.0095 15.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EDK36307.2 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase tRNA-synt_1c PF00749.21 EDK36308.2 - 2.3e-111 371.7 0.0 4.2e-110 367.5 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 EDK36308.2 - 1.3e-52 178.1 0.1 2.2e-52 177.3 0.1 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 EDK36308.2 - 1.2e-36 126.2 2.3 4.8e-36 124.2 0.3 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 EDK36308.2 - 1.6e-11 44.9 8.2 1.6e-11 44.9 8.2 2.5 2 1 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 VitK2_biosynth PF02621.14 EDK36308.2 - 0.017 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Menaquinone biosynthesis CBM_21 PF03370.13 EDK36309.2 - 2.7e-26 91.9 0.7 2.7e-26 91.9 0.7 1.8 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EDK36309.2 - 3.2e-08 34.1 0.2 7.4e-08 32.9 0.2 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Fmp27_WPPW PF10359.9 EDK36309.2 - 0.042 12.7 2.6 0.048 12.5 2.1 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Thg1C PF14413.6 EDK36310.2 - 8.4e-49 164.8 0.9 1.2e-48 164.3 0.9 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.12 EDK36310.2 - 1.4e-46 157.6 1.0 2.6e-46 156.7 0.2 1.7 2 0 0 2 2 2 1 tRNAHis guanylyltransferase MRP-S33 PF08293.11 EDK36310.2 - 0.077 13.2 0.3 0.24 11.7 0.3 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 RNA_pol_Rpb2_6 PF00562.28 EDK36311.2 - 4.8e-114 381.4 0.0 9.9e-114 380.4 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDK36311.2 - 3.1e-40 137.9 0.0 4.8e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDK36311.2 - 2.9e-30 105.3 0.0 8.7e-30 103.8 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EDK36311.2 - 3.2e-28 97.7 0.0 6.7e-28 96.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EDK36311.2 - 1.3e-24 86.0 0.0 2.6e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EDK36311.2 - 1.1e-16 60.9 0.0 2.3e-15 56.7 0.0 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_POL_M_15KD PF02150.16 EDK36311.2 - 0.0098 15.8 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit DiS_P_DiS PF06750.13 EDK36311.2 - 0.15 12.2 0.7 0.32 11.2 0.7 1.4 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain PRK PF00485.18 EDK36312.1 - 2.9e-09 37.0 0.0 3.7e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EDK36312.1 - 6.6e-07 29.6 0.2 6.8e-06 26.3 0.2 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EDK36312.1 - 9.7e-07 28.3 0.0 1.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EDK36312.1 - 3.3e-05 24.3 0.0 4.2e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EDK36312.1 - 7e-05 22.1 0.0 0.00011 21.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.12 EDK36312.1 - 0.00022 21.2 0.0 0.0004 20.4 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EDK36312.1 - 0.00033 20.9 0.0 0.00053 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK36312.1 - 0.00041 20.9 0.0 0.00061 20.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDK36312.1 - 0.00055 20.4 0.1 0.0073 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EDK36312.1 - 0.00088 19.2 0.0 0.0019 18.2 0.0 1.7 1 1 0 1 1 1 1 NTPase T2SSE PF00437.20 EDK36312.1 - 0.00098 18.3 0.0 0.0016 17.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein cobW PF02492.19 EDK36312.1 - 0.0014 18.2 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 EDK36312.1 - 0.0018 17.6 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EDK36312.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 EDK36312.1 - 0.0024 18.3 0.0 0.0041 17.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EDK36312.1 - 0.0034 16.6 0.0 0.0054 16.0 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EDK36312.1 - 0.0055 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain MeaB PF03308.16 EDK36312.1 - 0.0056 15.7 0.0 0.0093 15.0 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ResIII PF04851.15 EDK36312.1 - 0.006 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TsaE PF02367.17 EDK36312.1 - 0.0066 16.4 0.3 0.049 13.6 0.0 2.3 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EDK36312.1 - 0.0067 16.2 0.2 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EDK36312.1 - 0.0077 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 MobB PF03205.14 EDK36312.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EDK36312.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EDK36312.1 - 0.016 15.7 0.0 0.03 14.8 0.0 1.4 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 EDK36312.1 - 0.018 14.0 0.2 0.032 13.1 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Viral_helicase1 PF01443.18 EDK36312.1 - 0.024 14.4 0.0 0.044 13.5 0.0 1.4 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 EDK36312.1 - 0.024 14.9 0.1 0.054 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDK36312.1 - 0.03 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EDK36312.1 - 0.033 14.5 0.2 0.087 13.2 0.1 1.7 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDK36312.1 - 0.034 13.5 0.0 0.065 12.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 EDK36312.1 - 0.036 13.9 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase KAP_NTPase PF07693.14 EDK36312.1 - 0.04 13.1 0.0 0.067 12.4 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain AAA_14 PF13173.6 EDK36312.1 - 0.049 13.7 0.0 0.099 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EDK36312.1 - 0.071 12.4 0.1 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain EXOSC1 PF10447.9 EDK36312.1 - 0.089 13.4 1.1 0.25 12.0 0.0 2.1 2 1 1 3 3 2 0 Exosome component EXOSC1/CSL4 Roc PF08477.13 EDK36312.1 - 0.1 12.8 0.1 0.31 11.3 0.0 1.8 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase ADK PF00406.22 EDK36312.1 - 0.13 12.4 0.0 0.36 10.9 0.0 1.7 2 0 0 2 2 2 0 Adenylate kinase AAA_25 PF13481.6 EDK36312.1 - 0.14 11.7 0.2 0.22 11.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK36312.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain XLF PF09302.11 EDK36313.2 - 7.7e-15 55.5 0.1 1.7e-14 54.4 0.1 1.5 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component PIN_4 PF13638.6 EDK36314.2 - 2.3e-33 115.3 0.6 4.5e-33 114.3 0.1 1.8 2 0 0 2 2 2 1 PIN domain PIN_9 PF18477.1 EDK36314.2 - 0.029 14.7 0.2 0.63 10.4 0.2 2.6 1 1 0 1 1 1 0 PIN like domain DUF155 PF02582.14 EDK36315.2 - 4.8e-55 186.4 1.4 6.3e-55 186.0 0.1 1.9 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 tRNA-synt_1c PF00749.21 EDK36316.2 - 1.4e-112 375.7 0.0 1.8e-112 375.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDK36316.2 - 2.7e-41 141.3 0.2 6e-41 140.2 0.2 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain MFS_1 PF07690.16 EDK36317.2 - 3.9e-37 128.0 27.3 3.9e-37 128.0 27.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK36317.2 - 5.6e-12 45.3 24.4 1.3e-11 44.1 24.5 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDK36317.2 - 0.00027 19.5 1.0 0.00051 18.6 1.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SBDS PF01172.18 EDK36318.2 - 2.6e-20 72.3 0.1 3e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.20 EDK36319.2 - 3.3e-16 60.1 2.7 6e-16 59.2 2.7 1.4 1 0 0 1 1 1 1 RhoGEF domain DUF1320 PF07030.12 EDK36319.2 - 0.017 15.3 0.1 0.031 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) Tcf25 PF04910.14 EDK36320.2 - 4.6e-86 289.1 0.2 6.1e-86 288.6 0.2 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Fis1_TPR_C PF14853.6 EDK36320.2 - 0.011 15.7 0.1 0.96 9.6 0.0 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Aldedh PF00171.22 EDK36321.2 - 1.5e-125 419.4 0.0 1.7e-125 419.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF2202 PF09968.9 EDK36321.2 - 0.062 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein domain (DUF2202) V-ATPase_G PF03179.15 EDK36322.1 - 9e-24 84.0 12.5 9.6e-24 83.9 12.5 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 EDK36322.1 - 0.0016 17.9 10.3 0.0019 17.7 10.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 EDK36322.1 - 0.0033 17.5 11.0 0.0044 17.1 11.0 1.3 1 1 0 1 1 1 1 ATP synthase B/B' CF(0) RE_AlwI PF09491.10 EDK36322.1 - 0.0034 16.3 2.6 0.0035 16.2 2.6 1.0 1 0 0 1 1 1 1 AlwI restriction endonuclease UPF0242 PF06785.11 EDK36322.1 - 0.082 13.0 7.1 0.092 12.8 7.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RRF PF01765.19 EDK36322.1 - 0.71 9.8 8.8 0.81 9.6 8.8 1.1 1 0 0 1 1 1 0 Ribosome recycling factor DUF4407 PF14362.6 EDK36322.1 - 2 7.7 7.6 2 7.7 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 EDK36322.1 - 8.4 6.5 9.3 10 6.2 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Helicase_C PF00271.31 EDK36323.2 - 3.4e-20 72.4 0.3 1.2e-19 70.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OKR_DC_1_N PF03709.15 EDK36323.2 - 0.019 15.2 0.4 0.34 11.2 0.0 3.0 4 0 0 4 4 4 0 Orn/Lys/Arg decarboxylase, N-terminal domain SNF2_N PF00176.23 EDK36324.2 - 2.7e-62 210.5 0.1 2.7e-62 210.5 0.1 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 EDK36324.2 - 4.5e-12 46.3 0.0 4.5e-12 46.3 0.0 3.6 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit HSA PF07529.13 EDK36324.2 - 2.8e-09 37.2 8.0 2.8e-09 37.2 8.0 3.7 4 1 0 4 4 4 1 HSA DEAD PF00270.29 EDK36324.2 - 5.6e-05 23.0 0.0 0.00016 21.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Tugs PF17840.1 EDK36324.2 - 0.78 10.0 13.3 0.18 12.0 1.4 3.1 3 0 0 3 3 3 0 Tethering Ubl4a to BAGS domain NDUF_B8 PF05821.11 EDK36325.1 - 2e-07 31.0 0.1 2.9e-07 30.5 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) RRM_1 PF00076.22 EDK36327.2 - 4.3e-34 116.2 0.0 1.3e-12 47.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK36327.2 - 3.6e-05 23.6 0.0 0.0065 16.3 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDK36327.2 - 0.00016 21.6 0.0 0.00056 19.8 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EDK36327.2 - 0.0011 19.0 0.0 0.0034 17.4 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 EDK36327.2 - 0.0015 18.6 0.0 2.3 8.4 0.0 3.5 3 0 0 3 3 3 1 RNA recognition motif G-patch PF01585.23 EDK36328.2 - 2.6e-13 49.6 0.3 4.2e-13 49.0 0.3 1.4 1 0 0 1 1 1 1 G-patch domain DUF4187 PF13821.6 EDK36328.2 - 8.5e-10 38.3 4.3 2.8e-09 36.6 4.3 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch_2 PF12656.7 EDK36328.2 - 0.0019 18.3 1.8 0.0024 17.9 0.1 2.1 2 0 0 2 2 2 1 G-patch domain Med4 PF10018.9 EDK36329.2 - 3.2e-32 111.8 8.4 4.6e-32 111.3 8.4 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 RBFA PF02033.18 EDK36329.2 - 0.038 14.4 0.3 0.11 13.0 0.3 1.9 1 1 0 1 1 1 0 Ribosome-binding factor A Shugoshin_N PF07558.11 EDK36329.2 - 0.046 13.6 0.7 17 5.4 0.0 3.1 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region bZIP_1 PF00170.21 EDK36329.2 - 0.15 12.2 6.6 0.43 10.7 1.3 2.6 1 1 1 2 2 2 0 bZIP transcription factor Prominin PF05478.11 EDK36329.2 - 0.21 9.5 1.9 0.29 9.0 1.9 1.1 1 0 0 1 1 1 0 Prominin bZIP_2 PF07716.15 EDK36329.2 - 1.2 9.2 7.9 2.9 8.0 0.7 2.6 1 1 1 2 2 2 0 Basic region leucine zipper NYD-SP28_assoc PF14775.6 EDK36329.2 - 2.5 8.3 5.2 6.4 7.0 4.9 1.8 1 1 1 2 2 2 0 Sperm tail C-terminal domain YabA PF06156.13 EDK36329.2 - 3.9 8.2 11.4 2.5 8.8 6.4 2.6 2 1 0 2 2 2 0 Initiation control protein YabA Cnn_1N PF07989.11 EDK36329.2 - 6.3 7.0 11.9 3.2 8.0 6.7 3.0 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Ferrochelatase PF00762.19 EDK36330.1 - 2.8e-100 335.5 0.0 3.3e-100 335.3 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Glyco_transf_7C PF02709.14 EDK36330.1 - 0.056 13.1 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase MBOAT PF03062.19 EDK36331.2 - 2.7e-60 204.6 9.9 7.1e-60 203.2 9.9 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CPBP PF02517.16 EDK36331.2 - 0.067 13.6 4.9 0.48 10.8 0.7 3.5 2 1 1 3 3 3 0 CPBP intramembrane metalloprotease ADH_zinc_N PF00107.26 EDK36332.2 - 1.6e-13 50.7 0.4 3e-13 49.9 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK36332.2 - 8.7e-05 22.4 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDK36332.2 - 0.0025 18.9 0.1 0.0087 17.1 0.1 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Cnd1 PF12717.7 EDK36333.2 - 2.7e-44 151.1 4.3 1.7e-41 142.0 0.6 5.1 7 1 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 EDK36333.2 - 2.2e-39 135.0 1.2 8.3e-39 133.1 0.1 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 EDK36333.2 - 5.1e-11 41.8 2.5 0.42 11.0 0.0 6.4 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 EDK36333.2 - 5.2e-09 36.4 0.0 0.011 16.0 0.0 4.7 3 1 2 5 5 5 3 HEAT repeats Adaptin_N PF01602.20 EDK36333.2 - 8e-06 24.7 7.9 0.00083 18.0 0.0 4.0 3 2 2 5 5 5 2 Adaptin N terminal region Cnd3 PF12719.7 EDK36333.2 - 7.1e-05 22.1 6.6 0.00083 18.6 1.2 4.0 3 3 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 EDK36333.2 - 0.0001 22.7 1.6 7.8 7.1 0.0 6.5 7 0 0 7 7 7 1 HEAT-like repeat RTP1_C1 PF10363.9 EDK36333.2 - 0.00025 21.2 1.7 0.074 13.2 0.0 4.1 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 PI_PP_C PF18365.1 EDK36333.2 - 0.0063 16.5 0.1 0.039 13.9 0.0 2.5 3 0 0 3 3 3 1 Phosphoinositide phosphatase C-terminal domain YtzH PF14165.6 EDK36333.2 - 0.011 16.1 0.1 0.1 13.0 0.0 2.7 2 0 0 2 2 2 0 YtzH-like protein DUF2457 PF10446.9 EDK36333.2 - 0.42 9.7 9.3 0.94 8.5 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TAF4 PF05236.14 EDK36334.2 - 1.8e-62 211.6 9.7 2.9e-62 210.9 9.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family RTC PF01137.21 EDK36335.2 - 3.1e-41 141.0 0.0 3.8e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EDK36335.2 - 8.2e-31 106.6 0.1 1.3e-30 106.0 0.1 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain FAT PF02259.23 EDK36336.2 - 9.8e-143 475.5 0.2 9.8e-143 475.5 0.2 2.1 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EDK36336.2 - 3e-69 233.6 0.0 6.9e-69 232.4 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 EDK36336.2 - 1.2e-43 147.5 1.4 8.3e-43 144.8 0.3 3.0 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 EDK36336.2 - 3.4e-39 134.4 1.2 5.8e-36 123.8 0.0 4.0 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) FATC PF02260.20 EDK36336.2 - 4.2e-17 61.7 0.3 1.2e-16 60.2 0.3 1.8 1 0 0 1 1 1 1 FATC domain TPR_19 PF14559.6 EDK36336.2 - 0.00034 21.1 0.5 12 6.4 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat Adaptin_N PF01602.20 EDK36336.2 - 0.0016 17.1 1.2 0.0016 17.1 1.2 2.0 2 0 0 2 2 2 1 Adaptin N terminal region MOR2-PAG1_C PF14225.6 EDK36336.2 - 0.29 11.0 2.5 2.7 7.8 0.2 2.9 2 0 0 2 2 2 0 Cell morphogenesis C-terminal Xpo1 PF08389.12 EDK36336.2 - 0.61 10.1 3.6 2.9 7.9 0.1 4.1 5 1 0 5 5 4 0 Exportin 1-like protein Tti2 PF10521.9 EDK36336.2 - 0.97 8.9 5.4 5.2 6.5 0.1 3.4 3 1 0 4 4 4 0 Tti2 family HEAT_EZ PF13513.6 EDK36336.2 - 1 9.9 4.6 9.4 6.9 0.0 4.8 5 1 1 6 6 5 0 HEAT-like repeat TPR_16 PF13432.6 EDK36336.2 - 1.1 10.0 5.1 1.3 9.8 0.0 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Sec7_N PF12783.7 EDK36336.2 - 5.9 6.8 10.4 10 6.0 3.2 3.7 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Dopey_N PF04118.14 EDK36336.2 - 7.7 5.5 13.8 7.7 5.5 7.2 3.5 2 1 1 3 3 3 0 Dopey, N-terminal Actin PF00022.19 EDK36337.1 - 2e-90 303.4 0.0 6.6e-88 295.1 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EDK36337.1 - 0.00011 22.6 0.0 0.0012 19.3 0.0 2.4 2 1 0 2 2 2 1 Cell division protein FtsA MreB_Mbl PF06723.13 EDK36337.1 - 0.00053 18.9 0.0 0.14 10.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Cpn60_TCP1 PF00118.24 EDK36338.1 - 9.7e-156 519.2 2.5 1.1e-155 519.0 2.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cation_ATPase PF13246.6 EDK36338.1 - 0.039 14.0 0.0 0.096 12.8 0.0 1.8 1 0 0 1 1 1 0 Cation transport ATPase (P-type) HEAT_2 PF13646.6 EDK36339.2 - 5.2e-30 103.7 0.1 9.4e-13 48.4 0.0 3.6 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 EDK36339.2 - 4.7e-20 70.2 0.9 1.8e-05 24.9 0.0 7.0 9 1 0 9 9 9 4 PBS lyase HEAT-like repeat HEAT PF02985.22 EDK36339.2 - 2.1e-14 52.4 0.4 0.12 12.7 0.1 6.4 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.6 EDK36339.2 - 1.3e-09 38.3 0.4 0.86 10.2 0.0 4.8 4 1 0 4 4 4 4 HEAT-like repeat Cnd1 PF12717.7 EDK36339.2 - 0.037 14.1 3.2 18 5.3 0.1 4.0 2 2 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EDK36339.2 - 0.042 13.8 0.3 3.3 7.6 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3385) Arm PF00514.23 EDK36339.2 - 0.042 13.9 0.1 1.6 8.9 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Folliculin_C PF16692.5 EDK36339.2 - 0.11 12.1 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Folliculin C-terminal domain TFIIS_C PF01096.18 EDK36340.1 - 7.1e-18 64.2 1.5 7.1e-18 64.2 1.5 3.2 4 0 0 4 4 4 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDK36340.1 - 2.2e-10 40.2 5.6 5e-07 29.5 0.2 3.1 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 EDK36340.1 - 0.00017 21.6 6.8 0.038 14.0 0.3 2.7 2 1 0 2 2 2 2 Double zinc ribbon Baculo_LEF5_C PF11792.8 EDK36340.1 - 0.001 18.7 3.1 0.27 10.9 0.0 2.8 3 0 0 3 3 3 2 Baculoviridae late expression factor 5 C-terminal domain Zn_Tnp_IS1595 PF12760.7 EDK36340.1 - 0.0021 18.0 4.0 0.042 13.8 0.7 2.3 2 0 0 2 2 2 1 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EDK36340.1 - 0.0078 15.7 11.2 0.063 12.8 3.1 3.1 3 1 0 3 3 3 2 TFIIB zinc-binding zf-TFIIB PF13453.6 EDK36340.1 - 0.015 14.6 0.7 0.015 14.6 0.7 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger IBR PF01485.21 EDK36340.1 - 0.015 15.5 6.2 0.93 9.8 1.1 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C4_Topoisom PF01396.19 EDK36340.1 - 0.038 13.8 6.2 0.084 12.7 3.0 2.9 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Zn-ribbon_8 PF09723.10 EDK36340.1 - 0.042 14.0 11.4 2.6 8.2 0.1 3.3 3 0 0 3 3 3 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EDK36340.1 - 0.057 13.4 9.3 7 6.7 0.1 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EDK36340.1 - 0.071 12.5 9.3 1.8 8.1 0.6 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Nop10p PF04135.12 EDK36340.1 - 0.12 12.4 1.0 0.2 11.7 0.2 2.0 1 1 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family RecR PF02132.15 EDK36340.1 - 0.15 11.7 3.9 0.82 9.3 0.7 2.5 2 0 0 2 2 2 0 RecR protein zf-RING_7 PF02591.15 EDK36340.1 - 0.16 12.2 2.7 53 4.1 0.1 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain Fer4_10 PF13237.6 EDK36340.1 - 0.2 11.8 5.8 1.5 9.0 2.5 2.9 2 1 0 2 2 2 0 4Fe-4S dicluster domain Stc1 PF12898.7 EDK36340.1 - 0.22 12.1 6.2 0.65 10.6 0.4 2.3 1 1 1 2 2 2 0 Stc1 domain HypA PF01155.19 EDK36340.1 - 0.25 11.4 8.6 0.27 11.3 1.2 3.0 1 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Mu-like_Com PF10122.9 EDK36340.1 - 0.25 10.8 2.0 3.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com Lar_restr_allev PF14354.6 EDK36340.1 - 0.31 11.4 8.2 0.9 10.0 0.7 2.6 2 1 0 2 2 2 0 Restriction alleviation protein Lar Elf1 PF05129.13 EDK36340.1 - 0.33 11.0 7.6 2.5 8.2 0.5 2.6 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like NOB1_Zn_bind PF08772.11 EDK36340.1 - 0.35 11.1 7.5 18 5.6 4.9 3.1 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF2072 PF09845.9 EDK36340.1 - 0.36 11.1 0.1 0.36 11.1 0.1 2.6 1 1 1 3 3 3 0 Zn-ribbon containing protein zinc_ribbon_2 PF13240.6 EDK36340.1 - 0.45 10.3 18.1 1.5 8.7 1.3 3.5 3 1 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EDK36340.1 - 0.63 10.0 6.8 7.7 6.5 0.1 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-H2C2_2 PF13465.6 EDK36340.1 - 0.72 10.4 8.5 3.6 8.2 0.0 3.7 4 0 0 4 4 3 0 Zinc-finger double domain DpnI PF06044.12 EDK36340.1 - 1.2 8.8 3.8 5.9 6.5 0.3 2.1 1 1 1 2 2 2 0 Dam-replacing family Rubredoxin PF00301.20 EDK36340.1 - 1.5 8.9 7.5 39 4.4 0.0 3.6 4 0 0 4 4 4 0 Rubredoxin zinc_ribbon_15 PF17032.5 EDK36340.1 - 2.9 8.7 10.0 17 6.2 6.7 3.0 1 1 2 3 3 3 0 zinc-ribbon family zf-Mss51 PF13824.6 EDK36340.1 - 4.9 7.3 10.7 11 6.2 3.3 3.2 2 2 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Zn_Tnp_IS91 PF14319.6 EDK36340.1 - 6.5 6.9 8.5 9.3 6.4 2.3 2.8 1 1 2 3 3 3 0 Transposase zinc-binding domain zf-C2H2_4 PF13894.6 EDK36340.1 - 6.6 7.9 12.3 21 6.3 0.6 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger PADR1 PF08063.12 EDK36340.1 - 6.9 6.5 12.2 16 5.4 4.7 3.0 2 2 0 2 2 2 0 PADR1 (NUC008) domain Ogr_Delta PF04606.12 EDK36340.1 - 7.8 6.6 11.4 0.2 11.6 3.9 2.3 2 2 0 2 2 2 0 Ogr/Delta-like zinc finger DUF951 PF06107.11 EDK36340.1 - 8.4 6.4 6.3 11 6.0 0.1 3.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF951) Nudix_N_2 PF14803.6 EDK36340.1 - 10 6.2 13.0 9 6.3 1.6 3.4 3 1 0 3 3 2 0 Nudix N-terminal Na_H_Exchanger PF00999.21 EDK36341.2 - 1.6e-61 208.2 31.5 2.4e-61 207.7 31.5 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Flavin_Reduct PF01613.18 EDK36342.2 - 3.6e-18 66.1 0.1 5e-18 65.6 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DHquinase_II PF01220.19 EDK36343.2 - 2.1e-58 195.9 0.0 2.4e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 Dehydroquinase class II PAC2 PF09754.9 EDK36344.2 - 4.5e-23 82.4 0.0 7.4e-23 81.7 0.0 1.4 1 1 0 1 1 1 1 PAC2 family AFT PF08731.11 EDK36345.2 - 1.2e-27 96.5 6.6 2.5e-15 56.8 1.2 2.5 1 1 1 2 2 2 2 Transcription factor AFT Ribosomal_L12 PF00542.19 EDK36346.1 - 1.3e-21 76.7 6.7 1.3e-21 76.7 6.7 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EDK36346.1 - 4e-17 61.6 1.6 4e-17 61.6 1.6 2.4 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain TFIIS_C PF01096.18 EDK36347.1 - 1.2e-15 57.1 15.0 4.7e-15 55.1 5.5 3.0 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDK36347.1 - 2.2e-13 49.8 5.2 2.2e-13 49.8 5.2 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit zf-GRF PF06839.12 EDK36347.1 - 0.16 12.1 0.2 0.16 12.1 0.2 3.1 3 0 0 3 3 3 0 GRF zinc finger Zn_ribbon_recom PF13408.6 EDK36347.1 - 0.2 12.2 0.5 0.2 12.2 0.5 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DUF2387 PF09526.10 EDK36347.1 - 0.58 10.3 8.0 2.7 8.2 0.2 2.3 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) C1_4 PF07975.12 EDK36347.1 - 0.72 10.1 14.5 2.4 8.4 0.3 3.4 2 2 1 3 3 3 0 TFIIH C1-like domain Zn_Tnp_IS1595 PF12760.7 EDK36347.1 - 7.6 6.6 12.4 14 5.7 4.2 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_10 PF10058.9 EDK36347.1 - 9.8 6.0 12.1 2.2 8.1 2.0 2.7 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Pkinase PF00069.25 EDK36348.2 - 2.8e-73 246.5 0.0 5.1e-73 245.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36348.2 - 7.8e-40 136.8 0.0 1.5e-39 135.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36348.2 - 1.2e-05 24.8 1.5 1.6e-05 24.4 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK36348.2 - 3.8e-05 22.8 1.8 6e-05 22.1 1.8 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDK36348.2 - 0.029 14.3 2.1 0.64 9.9 0.0 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EDK36348.2 - 0.034 13.7 0.6 0.46 10.0 0.0 2.4 1 1 0 2 2 2 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 EDK36348.2 - 0.15 11.1 0.0 0.27 10.2 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Nramp PF01566.18 EDK36349.2 - 4.1e-83 279.3 18.4 3.4e-49 167.7 7.5 2.2 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein DUF1576 PF07613.11 EDK36349.2 - 0.0057 16.2 2.1 0.0057 16.2 2.1 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1576) HAD PF12710.7 EDK36350.1 - 8.8e-28 98.0 0.0 1.1e-27 97.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EDK36350.1 - 0.0019 17.8 0.0 0.011 15.3 0.0 1.9 2 0 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EDK36350.1 - 0.0048 16.3 0.0 0.066 12.6 0.0 2.1 1 1 0 1 1 1 1 Putative Phosphatase P3A PF08727.11 EDK36350.1 - 0.0088 15.4 0.1 1.3 8.5 0.0 3.0 3 0 0 3 3 3 1 Poliovirus 3A protein like HAD_2 PF13419.6 EDK36350.1 - 0.0093 16.1 0.0 0.48 10.5 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK36350.1 - 0.05 13.9 0.6 2 8.7 0.0 3.2 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase SpoU_sub_bind PF08032.12 EDK36350.1 - 0.18 12.1 0.0 1.2 9.5 0.0 2.2 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Pkinase PF00069.25 EDK36351.2 - 5.1e-69 232.6 0.0 9.3e-69 231.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36351.2 - 5.4e-32 111.1 0.0 1.4e-31 109.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36351.2 - 0.0007 19.0 0.3 1.8 7.8 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EDK36351.2 - 0.0041 15.9 0.0 0.01 14.6 0.0 1.7 1 1 0 1 1 1 1 Fungal protein kinase SNF2_N PF00176.23 EDK36352.2 - 1.3e-38 132.6 0.0 4.8e-37 127.5 0.0 2.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 EDK36352.2 - 0.0056 16.7 0.0 0.05 13.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 EDK36353.2 - 1e-09 38.1 7.1 2.3e-09 36.9 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK36353.2 - 4.2e-09 36.6 9.2 9.5e-09 35.5 9.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK36353.2 - 1.3e-08 34.5 9.0 3.3e-08 33.2 9.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK36353.2 - 2.3e-08 33.8 9.7 5.1e-08 32.7 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK36353.2 - 1.1e-06 28.4 5.9 2.3e-06 27.3 5.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EDK36353.2 - 6.1e-06 26.4 8.5 2.1e-05 24.7 8.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 EDK36353.2 - 4.5e-05 23.7 0.3 0.0002 21.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EDK36353.2 - 0.00029 20.7 8.3 0.00094 19.1 8.5 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDK36353.2 - 0.00033 20.6 6.2 0.0009 19.2 6.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Ykof PF07615.11 EDK36353.2 - 0.014 15.9 0.0 0.042 14.3 0.0 1.8 1 0 0 1 1 1 0 YKOF-related Family zf-HC5HC2H PF13771.6 EDK36353.2 - 0.06 13.6 5.7 0.042 14.1 2.8 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-ANAPC11 PF12861.7 EDK36353.2 - 0.099 12.7 1.2 0.23 11.5 1.2 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 EDK36353.2 - 0.11 12.2 6.2 0.26 11.0 6.2 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-C3HC4_4 PF15227.6 EDK36353.2 - 0.35 11.1 7.6 0.93 9.7 7.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-piccolo PF05715.13 EDK36353.2 - 0.36 11.0 5.5 10 6.4 1.6 2.6 2 0 0 2 2 2 0 Piccolo Zn-finger zf-RING_4 PF14570.6 EDK36353.2 - 0.39 10.5 7.4 0.083 12.7 3.4 1.8 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain Cript PF10235.9 EDK36353.2 - 0.76 10.4 4.9 2.9 8.5 4.9 2.0 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT RPA_C PF08784.11 EDK36354.2 - 2.4e-11 44.2 2.3 1e-10 42.2 0.1 2.4 2 1 1 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EDK36354.2 - 1.1e-05 25.4 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PCI PF01399.27 EDK36354.2 - 0.011 16.3 0.2 0.023 15.2 0.1 1.8 2 1 0 2 2 2 0 PCI domain RMI2 PF16100.5 EDK36354.2 - 0.05 13.4 0.1 0.09 12.6 0.1 1.5 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 Rrf2 PF02082.20 EDK36354.2 - 0.098 13.0 1.5 10 6.6 0.0 2.6 3 0 0 3 3 3 0 Transcriptional regulator L27_2 PF09045.10 EDK36355.2 - 0.14 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 L27_2 Glycoprotein_G PF00802.19 EDK36355.2 - 7.1 5.9 11.0 0.93 8.8 5.4 2.2 2 0 0 2 2 2 0 Pneumovirus attachment glycoprotein G SWIB PF02201.18 EDK36356.2 - 7.5e-09 35.3 0.1 0.00027 20.7 0.0 2.5 2 0 0 2 2 2 2 SWIB/MDM2 domain Cyt-b5 PF00173.28 EDK36357.2 - 2.5e-12 46.8 0.0 5.6e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 EDK36357.2 - 4.3e-11 43.1 8.6 4.3e-11 43.1 8.6 2.4 1 1 1 2 2 2 1 Fatty acid desaturase DUF4519 PF15012.6 EDK36357.2 - 5.9 7.1 6.2 51 4.1 1.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) CBS PF00571.28 EDK36358.1 - 7.6e-14 51.9 0.0 1.1e-07 32.2 0.0 2.2 2 0 0 2 2 2 2 CBS domain RRM_1 PF00076.22 EDK36359.2 - 4.9e-31 106.4 0.0 2.8e-15 55.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK36359.2 - 0.0011 19.1 0.0 0.016 15.3 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif Ribosomal_L9_N PF01281.19 EDK36360.2 - 3e-09 36.3 0.0 6.1e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain HCV_capsid PF01543.17 EDK36360.2 - 0.08 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus capsid protein zf-HIT PF04438.16 EDK36361.2 - 5.1e-11 42.3 8.7 8.5e-11 41.5 8.7 1.4 1 0 0 1 1 1 1 HIT zinc finger DUF2752 PF10825.8 EDK36361.2 - 0.21 11.7 0.0 0.41 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) zf-B_box PF00643.24 EDK36361.2 - 0.6 10.3 5.7 1.1 9.5 5.7 1.4 1 0 0 1 1 1 0 B-box zinc finger BUD22 PF09073.10 EDK36361.2 - 2.1 7.6 13.3 3.6 6.8 13.3 1.3 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EDK36361.2 - 4.6 5.3 9.5 6.2 4.9 9.5 1.1 1 0 0 1 1 1 0 Nop14-like family Stk19 PF10494.9 EDK36362.2 - 4.1e-77 259.2 0.1 1.4e-76 257.4 0.0 1.7 2 0 0 2 2 2 1 Serine-threonine protein kinase 19 DUF1682 PF07946.14 EDK36363.2 - 6.4e-88 295.1 9.3 7.2e-88 294.9 9.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Helicase_C PF00271.31 EDK36363.2 - 0.059 13.7 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 Helicase conserved C-terminal domain POTRA PF07244.15 EDK36363.2 - 0.28 11.8 3.7 13 6.5 0.0 2.8 2 0 0 2 2 2 0 Surface antigen variable number repeat Ank_4 PF13637.6 EDK36364.2 - 1.5e-15 57.3 1.1 1.4e-08 35.1 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK36364.2 - 5.7e-14 52.0 0.0 1.5e-11 44.3 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDK36364.2 - 3.3e-10 40.4 0.2 7.9e-10 39.2 0.1 1.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EDK36364.2 - 8.1e-08 32.4 0.4 1.5e-05 25.2 0.3 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EDK36364.2 - 7.8e-06 25.9 1.5 0.00013 22.1 0.1 3.2 4 0 0 4 4 4 1 Ankyrin repeat TrpBP PF02081.15 EDK36364.2 - 0.14 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein Peptidase_M76 PF09768.9 EDK36365.2 - 9.7e-70 233.8 0.5 1.2e-69 233.5 0.5 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EDK36365.2 - 0.006 16.4 0.2 0.012 15.4 0.2 1.7 1 1 0 1 1 1 1 SprT-like family Peptidase_M91 PF14891.6 EDK36365.2 - 0.083 13.2 0.3 0.12 12.6 0.3 1.5 1 1 0 1 1 1 0 Effector protein BSP PF04450.12 EDK36365.2 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria MBOAT PF03062.19 EDK36366.2 - 1e-54 186.2 29.1 1.4e-50 172.6 16.5 2.2 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EDK36366.2 - 0.22 11.8 7.6 0.044 14.0 3.3 2.0 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family WBS_methylT PF12589.8 EDK36367.1 - 6.2e-13 49.3 7.9 1e-12 48.6 7.9 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EDK36367.1 - 9.4e-13 48.6 0.0 2e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36367.1 - 8.6e-11 42.4 0.0 2.2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36367.1 - 6.1e-08 33.3 0.1 2.2e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK36367.1 - 5.9e-05 23.0 0.0 9.3e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36367.1 - 0.00011 22.1 0.0 0.00027 20.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 EDK36367.1 - 0.00024 21.4 0.0 0.00067 20.0 0.0 1.8 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase N6_N4_Mtase PF01555.18 EDK36367.1 - 0.0082 15.9 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 1 DNA methylase PCMT PF01135.19 EDK36367.1 - 0.0096 15.7 0.0 0.061 13.1 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EDK36367.1 - 0.016 14.5 0.0 0.087 12.1 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EDK36367.1 - 0.019 14.4 0.1 0.046 13.1 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EDK36367.1 - 0.041 13.9 0.5 0.55 10.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EDK36367.1 - 0.09 12.3 0.2 1.6 8.2 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase small domain DUF727 PF05303.12 EDK36368.2 - 1.2e-08 34.9 0.5 6.7e-07 29.3 0.5 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF727) LSM PF01423.22 EDK36369.1 - 1.4e-08 34.3 0.1 2e-08 33.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDK36369.1 - 0.0094 16.1 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain EFP PF01132.20 EDK36369.1 - 0.16 12.0 0.1 0.39 10.8 0.1 1.7 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain TetR_C_8 PF14278.6 EDK36370.2 - 0.13 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region ABC_tran PF00005.27 EDK36372.1 - 3.6e-46 157.1 0.1 3.1e-23 82.8 0.0 4.5 3 2 0 3 3 3 2 ABC transporter 4HB PF17947.1 EDK36372.1 - 5.4e-28 96.9 0.3 2.4e-27 94.8 0.1 2.4 2 0 0 2 2 1 1 Four helical bundle domain AAA_21 PF13304.6 EDK36372.1 - 1.1e-16 61.5 0.7 0.0046 16.8 0.0 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDK36372.1 - 7.4e-15 55.0 0.3 5.7e-05 22.7 0.1 4.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDK36372.1 - 3.7e-11 43.9 7.7 0.00015 22.3 0.0 3.8 4 0 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 EDK36372.1 - 2.1e-09 37.5 0.0 0.00019 21.4 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDK36372.1 - 1e-08 34.8 0.0 0.006 16.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 EDK36372.1 - 5.2e-08 33.3 0.1 0.00096 19.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDK36372.1 - 1.5e-07 31.5 0.0 0.0025 17.9 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EDK36372.1 - 7.4e-07 29.5 0.2 0.034 14.4 0.0 3.7 4 1 0 4 4 2 2 AAA domain RNA_helicase PF00910.22 EDK36372.1 - 8.2e-06 26.2 0.0 0.16 12.4 0.0 3.1 2 1 0 2 2 2 2 RNA helicase MMS19_C PF12460.8 EDK36372.1 - 8.5e-06 25.1 1.0 0.0047 16.1 0.2 2.5 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal AAA_18 PF13238.6 EDK36372.1 - 8.7e-06 26.3 0.1 0.2 12.2 0.0 3.5 3 0 0 3 3 2 2 AAA domain Dynamin_N PF00350.23 EDK36372.1 - 2.3e-05 24.5 0.0 0.0012 18.9 0.0 3.0 2 0 0 2 2 2 1 Dynamin family MeaB PF03308.16 EDK36372.1 - 3.5e-05 22.9 0.0 0.098 11.6 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EDK36372.1 - 6.1e-05 22.9 4.1 0.2 11.3 0.0 4.1 4 0 0 4 4 4 2 AAA ATPase domain AAA PF00004.29 EDK36372.1 - 7.2e-05 23.2 0.2 0.63 10.5 0.0 4.3 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EDK36372.1 - 9.3e-05 22.6 0.0 0.68 10.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDK36372.1 - 0.00012 22.5 0.1 0.23 11.8 0.0 3.5 4 0 0 4 4 3 1 AAA ATPase domain AAA_27 PF13514.6 EDK36372.1 - 0.00018 21.2 0.0 0.21 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EDK36372.1 - 0.00067 19.8 0.0 0.79 10.0 0.0 3.8 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit Adaptin_N PF01602.20 EDK36372.1 - 0.0009 17.9 6.6 0.0049 15.5 2.3 2.6 1 1 1 2 2 2 1 Adaptin N terminal region AAA_30 PF13604.6 EDK36372.1 - 0.00094 18.9 0.0 2 8.1 0.0 3.4 4 0 0 4 4 3 1 AAA domain PduV-EutP PF10662.9 EDK36372.1 - 0.0021 17.8 0.0 0.12 12.1 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EDK36372.1 - 0.0022 17.8 0.1 1.6 8.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain HEAT_2 PF13646.6 EDK36372.1 - 0.0031 17.9 0.9 0.051 14.0 0.4 3.1 2 1 2 4 4 3 2 HEAT repeats ATPase_2 PF01637.18 EDK36372.1 - 0.0036 17.2 0.1 5 7.0 0.0 3.4 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 EDK36372.1 - 0.0049 16.5 0.0 3.1 7.3 0.0 3.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 EDK36372.1 - 0.0054 16.7 0.0 3.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 EDK36372.1 - 0.0054 16.7 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 EDK36372.1 - 0.0059 16.6 0.0 8.1 6.5 0.0 3.3 3 0 0 3 3 2 0 AAA domain CLP1_P PF16575.5 EDK36372.1 - 0.0065 16.3 0.0 1.1 9.1 0.0 3.0 3 0 0 3 3 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop IstB_IS21 PF01695.17 EDK36372.1 - 0.014 15.2 0.0 3.9 7.2 0.0 3.0 3 0 0 3 3 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 EDK36372.1 - 0.014 15.1 0.0 6.8 6.4 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase Ploopntkinase3 PF18751.1 EDK36372.1 - 0.015 15.2 0.0 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EDK36372.1 - 0.016 15.4 0.0 9.7 6.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EDK36372.1 - 0.02 15.0 8.9 0.4 10.7 0.0 4.6 6 0 0 6 6 3 0 Helicase HerA, central domain Mg_chelatase PF01078.21 EDK36372.1 - 0.043 13.2 0.0 1.4 8.2 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EDK36372.1 - 0.052 13.1 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EDK36372.1 - 0.053 13.3 0.4 7.7 6.2 0.1 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MutS_V PF00488.21 EDK36372.1 - 0.053 13.5 0.1 6.4 6.7 0.1 2.6 2 0 0 2 2 2 0 MutS domain V Septin PF00735.18 EDK36372.1 - 0.057 12.7 1.2 3.8 6.7 0.0 2.9 3 0 0 3 3 3 0 Septin Zeta_toxin PF06414.12 EDK36372.1 - 0.058 12.7 0.3 13 5.0 0.0 3.2 4 0 0 4 4 3 0 Zeta toxin G-alpha PF00503.20 EDK36372.1 - 0.06 12.5 0.1 10 5.1 0.0 2.6 3 0 0 3 3 2 0 G-protein alpha subunit TsaE PF02367.17 EDK36372.1 - 0.063 13.3 0.0 6 6.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 EDK36372.1 - 0.07 12.7 0.0 16 5.0 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain ParcG PF10274.9 EDK36372.1 - 0.072 13.2 0.5 12 6.0 0.1 2.9 2 1 1 3 3 2 0 Parkin co-regulated protein MukB PF04310.12 EDK36372.1 - 0.073 12.9 0.1 11 5.8 0.0 2.7 2 0 0 2 2 2 0 MukB N-terminal NTPase_1 PF03266.15 EDK36372.1 - 0.075 12.9 0.1 19 5.2 0.1 2.8 2 0 0 2 2 2 0 NTPase Adeno_IVa2 PF02456.15 EDK36372.1 - 0.13 11.0 0.1 6.6 5.4 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein RE_HindVP PF09519.10 EDK36372.1 - 0.13 11.2 0.3 0.28 10.2 0.3 1.4 1 0 0 1 1 1 0 HindVP restriction endonuclease Vac14_Fab1_bd PF12755.7 EDK36372.1 - 0.15 12.7 0.0 6.6 7.4 0.0 2.9 2 1 1 3 3 2 0 Vacuolar 14 Fab1-binding region FeoB_N PF02421.18 EDK36372.1 - 0.17 11.4 0.4 1.2 8.7 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF3349 PF11829.8 EDK36372.1 - 0.19 12.5 0.4 1.4 9.8 0.1 2.7 2 0 0 2 2 1 0 Protein of unknown function (DUF3349) AAA_17 PF13207.6 EDK36372.1 - 1.1 9.7 4.0 70 3.8 0.4 4.2 3 1 0 3 3 2 0 AAA domain HEAT_EZ PF13513.6 EDK36372.1 - 6 7.5 6.0 30 5.2 0.4 4.0 4 1 2 6 6 3 0 HEAT-like repeat MMS19_N PF14500.6 EDK36372.1 - 6.3 6.3 6.6 3 7.3 0.1 3.3 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II AAA_13 PF13166.6 EDK36372.1 - 6.4 5.3 14.9 1.1 7.8 0.0 4.1 5 0 0 5 5 5 0 AAA domain Ammonium_transp PF00909.21 EDK36373.2 - 4.4e-76 256.1 21.7 5.4e-76 255.9 21.7 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Mito_carr PF00153.27 EDK36374.1 - 7.8e-66 218.1 1.0 1.4e-21 76.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DPM3 PF08285.11 EDK36374.1 - 0.099 12.9 0.0 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) SMP_2 PF10144.9 EDK36374.1 - 0.18 11.4 0.0 1.5 8.5 0.0 2.2 3 0 0 3 3 3 0 Bacterial virulence factor haemolysin SOG2 PF10428.9 EDK36375.2 - 1.6e-57 195.9 14.6 8.2e-32 111.1 4.1 4.8 2 1 2 4 4 4 2 RAM signalling pathway protein LRR_8 PF13855.6 EDK36375.2 - 1.1e-10 41.2 13.0 2.3e-07 30.4 3.0 2.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EDK36375.2 - 1.8e-09 37.7 16.4 8.4e-05 22.9 3.2 3.9 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDK36375.2 - 0.061 13.9 11.7 44 5.2 0.2 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat XhlA PF10779.9 EDK36375.2 - 0.12 12.6 0.1 0.4 10.9 0.1 1.9 1 0 0 1 1 1 0 Haemolysin XhlA LRR_6 PF13516.6 EDK36375.2 - 0.32 11.2 8.5 48 4.4 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeat HMA PF00403.26 EDK36376.2 - 5e-11 42.9 0.1 9.9e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EDK36376.2 - 0.0096 16.1 0.0 0.12 12.5 0.0 2.3 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) RusA PF05866.11 EDK36376.2 - 0.1 13.1 0.4 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA DUF3419 PF11899.8 EDK36377.2 - 3.6e-157 523.5 0.2 5.5e-157 522.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EDK36377.2 - 1.3e-10 41.4 0.0 5.5e-10 39.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36377.2 - 4.4e-10 40.2 0.1 6.5e-09 36.4 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK36377.2 - 6.3e-10 38.8 0.0 1.3e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDK36377.2 - 9.9e-10 39.0 0.0 4.8e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK36377.2 - 1.9e-08 34.8 0.0 5.5e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36377.2 - 1.1e-07 31.8 0.0 2.7e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EDK36377.2 - 0.019 14.3 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_28 PF02636.17 EDK36377.2 - 0.032 13.9 0.0 0.097 12.3 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 EDK36377.2 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CM_2 PF01817.21 EDK36378.1 - 0.001 19.4 0.0 0.71 10.3 0.0 2.5 2 0 0 2 2 2 2 Chorismate mutase type II DnaJ PF00226.31 EDK36379.2 - 3.6e-08 33.4 0.9 3.6e-08 33.4 0.9 2.3 2 0 0 2 2 2 1 DnaJ domain Myco_arth_vir_N PF09610.10 EDK36379.2 - 0.063 13.4 0.7 0.17 12.0 0.7 1.7 1 1 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Amidohydro_1 PF01979.20 EDK36380.2 - 2.4e-15 56.7 0.0 3.7e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EDK36380.2 - 3.3e-11 43.4 0.3 8e-08 32.2 0.0 2.9 3 0 0 3 3 3 2 Amidohydrolase family Glucosamine_iso PF01182.20 EDK36381.2 - 4.8e-18 65.9 0.0 8.6e-18 65.0 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Hexokinase_2 PF03727.16 EDK36382.2 - 6.1e-51 173.2 0.0 9.3e-51 172.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDK36382.2 - 4.5e-33 114.8 0.0 1.1e-32 113.6 0.0 1.6 2 0 0 2 2 2 1 Hexokinase RHD3 PF05879.12 EDK36383.2 - 1.3e-257 856.8 13.9 1.5e-257 856.6 13.9 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EDK36383.2 - 7.2e-08 32.0 0.2 7.2e-08 32.0 0.2 2.1 3 0 0 3 3 3 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EDK36383.2 - 6.9e-06 26.1 0.1 2.5e-05 24.3 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDK36383.2 - 0.00032 20.8 0.1 0.0011 19.0 0.1 1.9 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 EDK36383.2 - 0.00095 19.4 0.0 0.0025 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 EDK36383.2 - 0.044 14.0 0.0 0.3 11.3 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mit_ribos_Mrp51 PF11709.8 EDK36383.2 - 0.12 12.0 0.4 0.3 10.6 0.1 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit SCNM1_acidic PF15805.5 EDK36383.2 - 8.2 6.2 7.4 19 5.1 7.4 1.6 1 0 0 1 1 1 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 GTP_EFTU PF00009.27 EDK36384.2 - 6.6e-64 215.0 0.2 1.1e-63 214.3 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDK36384.2 - 3.5e-23 81.5 0.0 8e-23 80.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDK36384.2 - 3.5e-14 52.6 0.2 1.4e-07 31.5 0.0 3.1 3 0 0 3 3 3 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDK36384.2 - 1.2e-10 41.6 0.4 1.2e-10 41.6 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK36384.2 - 0.00078 19.5 0.1 0.0023 18.0 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EDK36384.2 - 0.0014 18.5 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MFS_1 PF07690.16 EDK36385.1 - 1.4e-17 63.6 60.6 3.4e-09 36.1 28.3 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK36385.1 - 1.4e-05 23.8 44.1 0.0011 17.6 21.7 2.8 1 1 2 3 3 3 3 MFS/sugar transport protein LRR_8 PF13855.6 EDK36386.2 - 5.7e-21 74.1 27.7 6.1e-07 29.1 0.3 7.5 6 1 2 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EDK36386.2 - 7.9e-18 64.3 40.2 9.2e-06 25.9 2.8 9.1 4 3 9 13 13 13 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK36386.2 - 3.9e-10 39.0 9.2 0.63 10.3 0.0 9.8 10 0 0 10 10 10 2 Leucine Rich repeat LRR_5 PF13306.6 EDK36386.2 - 3.7e-08 33.4 2.6 0.045 13.7 0.2 4.8 2 1 3 5 5 5 4 BspA type Leucine rich repeat region (6 copies) FNIP PF05725.12 EDK36386.2 - 4.3e-06 26.8 32.6 0.00013 22.0 2.4 7.4 8 1 0 8 8 8 2 FNIP Repeat LRR_1 PF00560.33 EDK36386.2 - 0.0001 22.4 26.1 1.4 9.7 0.2 9.5 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 EDK36386.2 - 0.002 17.7 3.9 1.2 8.6 0.1 3.3 2 1 0 2 2 2 2 Leucine-rich repeat EIF_2_alpha PF07541.12 EDK36387.1 - 4.1e-36 123.6 0.1 7.9e-36 122.7 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EDK36387.1 - 1.8e-15 57.0 0.9 3.3e-15 56.2 0.9 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Troponin PF00992.20 EDK36387.1 - 0.0017 18.6 1.5 0.0035 17.6 1.5 1.4 1 0 0 1 1 1 1 Troponin Treacle PF03546.14 EDK36387.1 - 0.016 14.1 0.2 0.019 13.8 0.2 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle tRNA-Thr_ED PF08915.11 EDK36387.1 - 0.032 14.3 0.1 0.063 13.3 0.1 1.5 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase Pkinase PF00069.25 EDK36388.2 - 1.4e-12 47.5 0.0 1.7e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Glyco_hydro_2_N PF02837.18 EDK36388.2 - 0.047 13.6 0.0 0.06 13.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain DUF4309 PF14172.6 EDK36388.2 - 0.13 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4309) Rho_GDI PF02115.17 EDK36389.2 - 3e-20 72.8 0.9 3.3e-20 72.6 0.9 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF4945 PF16303.5 EDK36389.2 - 0.069 13.1 1.1 0.12 12.3 1.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4945) Memo PF01875.17 EDK36390.1 - 3.6e-78 262.4 0.0 4.2e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Adaptin_N PF01602.20 EDK36391.2 - 3.2e-93 313.1 9.4 3.9e-93 312.8 9.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDK36391.2 - 1.2e-42 145.7 4.4 2.7e-41 141.3 0.0 3.6 3 1 1 4 4 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDK36391.2 - 1.7e-16 60.3 2.7 0.00011 22.5 0.1 5.4 5 0 0 5 5 5 4 HEAT repeats HEAT PF02985.22 EDK36391.2 - 1.4e-08 34.2 1.2 0.14 12.5 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat Cnd3 PF12719.7 EDK36391.2 - 4.3e-06 26.1 1.5 0.08 12.1 0.1 3.3 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 EDK36391.2 - 0.00025 21.2 0.5 0.26 11.5 0.1 4.0 3 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EDK36391.2 - 0.00046 20.1 1.9 2.2 8.5 0.0 5.1 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat DUF5578 PF17741.1 EDK36391.2 - 0.043 13.2 2.4 1.3 8.4 0.1 3.5 3 1 0 3 3 3 0 Family of unknown function (DUF5578) T_hemolysin PF12261.8 EDK36391.2 - 0.12 12.1 0.0 0.36 10.6 0.0 1.8 1 0 0 1 1 1 0 Thermostable hemolysin RasGEF_N_2 PF14663.6 EDK36391.2 - 0.27 11.7 1.9 21 5.6 0.0 4.3 5 1 0 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_EZ PF13513.6 EDK36391.2 - 2.2 8.9 7.2 13 6.4 0.1 5.1 6 2 1 7 7 7 0 HEAT-like repeat DEAD PF00270.29 EDK36392.2 - 7.1e-25 87.8 0.0 3.2e-23 82.4 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EDK36392.2 - 1.2e-15 58.0 1.2 1.3e-14 54.7 0.4 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EDK36392.2 - 8e-15 55.1 0.0 1.5e-13 51.0 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Cellulase PF00150.18 EDK36393.2 - 4.4e-12 46.0 2.8 6.4e-12 45.5 2.8 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) UCH PF00443.29 EDK36394.2 - 8.1e-62 209.0 0.5 8.1e-62 209.0 0.5 1.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK36394.2 - 2.9e-26 92.8 0.5 2.9e-26 92.8 0.5 2.1 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EDK36394.2 - 0.11 13.0 0.2 0.33 11.5 0.1 1.8 2 0 0 2 2 2 0 Rhodanese-like domain Peptidase_C98 PF15499.6 EDK36394.2 - 3 7.3 6.2 1.2 8.5 0.0 3.2 5 0 0 5 5 5 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Y_phosphatase2 PF03162.13 EDK36395.2 - 8.2e-43 145.8 0.0 1e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDK36395.2 - 0.013 15.1 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SH3_2 PF07653.17 EDK36395.2 - 0.12 12.1 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Aminotran_1_2 PF00155.21 EDK36396.2 - 7e-63 213.0 0.0 8.4e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK36396.2 - 0.014 14.7 0.0 0.076 12.3 0.0 1.9 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EDK36396.2 - 0.047 12.6 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDK36396.2 - 0.17 11.1 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase ABC_tran PF00005.27 EDK36397.2 - 8.3e-22 78.2 0.0 7.1e-11 42.8 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDK36397.2 - 1.9e-05 24.7 1.4 0.46 10.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDK36397.2 - 0.00059 20.0 0.2 0.16 12.2 0.1 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EDK36397.2 - 0.21 12.0 2.6 0.21 12.1 1.3 1.6 2 0 0 2 2 2 0 AAA domain BSD PF03909.17 EDK36398.2 - 5.4e-18 64.7 0.3 1.7e-17 63.2 0.2 1.9 2 0 0 2 2 2 1 BSD domain Globin PF00042.22 EDK36398.2 - 0.0058 17.2 1.1 0.0058 17.2 1.1 2.5 2 1 0 2 2 2 1 Globin Baculo_PEP_C PF04513.12 EDK36398.2 - 0.9 9.6 5.8 3.3 7.7 0.6 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PBP1_TM PF14812.6 EDK36398.2 - 2.5 8.5 10.2 7.6 7.0 10.2 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Fzo_mitofusin PF04799.13 EDK36398.2 - 4.9 6.7 7.6 2 8.0 3.4 2.2 2 0 0 2 2 2 0 fzo-like conserved region Metallophos PF00149.28 EDK36401.2 - 3.9e-14 53.6 0.1 8.7e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3433 PF11915.8 EDK36401.2 - 0.11 13.0 0.2 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3433) G-alpha PF00503.20 EDK36402.2 - 2.9e-109 365.5 2.3 3.7e-109 365.1 2.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EDK36402.2 - 1.2e-16 60.6 0.7 1.1e-11 44.5 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK36402.2 - 0.0011 18.4 0.3 0.046 13.1 0.0 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EDK36402.2 - 0.012 15.8 0.9 4.7 7.4 0.1 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDK36402.2 - 0.025 14.7 0.0 1.8 8.7 0.0 2.7 3 0 0 3 3 3 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK36402.2 - 0.087 12.4 0.0 0.99 8.9 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Peptidase_M16_C PF05193.21 EDK36403.1 - 2.6e-19 70.0 0.1 1.1e-18 67.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDK36403.1 - 1.9e-09 37.6 0.3 2.9e-07 30.6 0.3 2.5 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) Ribosomal_S7 PF00177.21 EDK36405.2 - 1.9e-34 118.5 0.5 3.3e-34 117.7 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein S7p/S5e CybS PF05328.12 EDK36406.2 - 8.7e-57 190.5 0.1 1e-56 190.3 0.1 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Ribosomal_S14 PF00253.21 EDK36407.1 - 2.8e-10 39.8 0.0 1.4e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Lum_binding PF00677.17 EDK36408.2 - 5.4e-44 148.1 2.7 2.1e-21 75.7 0.3 2.2 2 0 0 2 2 2 2 Lumazine binding domain YqzH PF14164.6 EDK36408.2 - 0.14 12.3 0.1 0.73 10.0 0.1 2.1 1 1 1 2 2 2 0 YqzH-like protein Proteasome PF00227.26 EDK36409.1 - 4.1e-40 137.3 0.0 4.7e-40 137.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Herpes_UL3 PF03369.13 EDK36409.1 - 0.13 12.8 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL3 protein SAMP PF05924.11 EDK36409.1 - 0.15 11.4 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 SAMP Motif OB_NTP_bind PF07717.16 EDK36410.2 - 1.2e-22 80.0 0.0 2.9e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDK36410.2 - 2.8e-21 75.8 0.0 2.8e-21 75.8 0.0 2.5 3 0 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK36410.2 - 4.2e-13 49.6 0.0 1.4e-12 47.9 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EDK36410.2 - 2.2e-12 47.2 0.4 7.5e-12 45.4 0.4 2.0 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 EDK36410.2 - 1e-09 38.4 0.2 2.1e-09 37.4 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK36410.2 - 7.8e-06 26.2 0.0 2.2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK36410.2 - 0.00055 20.3 0.1 0.001 19.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDK36410.2 - 0.00073 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDK36410.2 - 0.00096 18.5 0.1 0.002 17.4 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 EDK36410.2 - 0.0087 16.1 0.5 0.26 11.3 0.5 2.5 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDK36410.2 - 0.024 13.7 0.0 0.053 12.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 EDK36410.2 - 0.04 13.6 0.8 0.16 11.6 0.8 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 EDK36410.2 - 0.044 13.1 0.1 0.094 12.0 0.1 1.5 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 EDK36410.2 - 0.048 14.2 8.0 0.074 13.6 0.1 3.7 3 1 0 3 3 3 0 ABC transporter AAA_11 PF13086.6 EDK36410.2 - 0.55 10.0 0.0 0.55 10.0 0.0 3.2 2 1 0 2 2 1 0 AAA domain Cellulase PF00150.18 EDK36411.2 - 7e-08 32.2 0.0 1.4e-06 28.0 0.1 2.6 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF2179 PF10035.9 EDK36411.2 - 0.0038 17.0 0.2 0.0075 16.0 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2179) Glyco_hydro_5_C PF18564.1 EDK36412.2 - 2.8e-07 31.0 0.0 6.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain DNA_primase_S PF01896.19 EDK36413.2 - 3.9e-65 219.2 0.6 1.4e-64 217.4 0.4 1.8 2 0 0 2 2 2 1 DNA primase small subunit ANAPC4_WD40 PF12894.7 EDK36414.2 - 8.7e-09 35.6 2.9 0.01 16.1 0.2 4.6 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK36414.2 - 3.5e-07 30.8 8.0 0.37 11.7 0.3 6.7 6 1 0 6 6 6 2 WD domain, G-beta repeat PQQ_2 PF13360.6 EDK36414.2 - 8.8e-07 28.7 2.6 8.9e-06 25.5 0.4 2.7 2 1 0 2 2 2 1 PQQ-like domain WD40_like PF17005.5 EDK36414.2 - 1.6e-05 24.4 0.0 0.04 13.2 0.0 3.1 1 1 2 3 3 3 2 WD40-like domain PQQ PF01011.21 EDK36414.2 - 0.0029 17.4 0.2 6.9 6.8 0.0 3.6 4 0 0 4 4 4 2 PQQ enzyme repeat DUF5046 PF16465.5 EDK36414.2 - 0.05 13.1 0.3 0.11 11.9 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) FAA_hydro_N_2 PF18288.1 EDK36414.2 - 0.36 11.3 0.9 1.1 9.7 0.1 2.1 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 Prenyltransf PF01255.19 EDK36415.2 - 2e-71 240.1 0.0 2.3e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase HisG PF01634.18 EDK36416.1 - 6e-54 182.3 0.3 8e-54 181.9 0.3 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EDK36416.1 - 8.3e-27 93.2 0.1 1.7e-26 92.1 0.1 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain Aminotran_5 PF00266.19 EDK36417.2 - 9.3e-17 61.0 0.0 1.3e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EDK36417.2 - 5.5e-06 25.2 0.0 7.2e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK36417.2 - 0.013 14.7 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK36417.2 - 0.12 11.7 0.0 0.25 10.6 0.0 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family PCI PF01399.27 EDK36418.2 - 2.3e-17 63.4 0.8 2.3e-17 63.4 0.8 2.4 2 1 1 3 3 3 1 PCI domain RPN5_C PF18098.1 EDK36418.2 - 2.8e-15 56.1 2.0 1.1e-14 54.3 2.0 2.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain DUF3336 PF11815.8 EDK36418.2 - 0.047 13.4 6.3 1.8 8.3 0.6 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF3336) Glyco_hydro_72 PF03198.14 EDK36419.2 - 1.3e-137 458.3 8.2 1.7e-137 457.9 8.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EDK36419.2 - 0.0015 18.0 1.0 0.014 14.8 1.0 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Borrelia_orfD PF02999.14 EDK36419.2 - 0.96 9.8 3.4 0.35 11.2 0.5 1.7 2 0 0 2 2 2 0 Borrelia orf-D family Adap_comp_sub PF00928.21 EDK36420.2 - 4.4e-86 288.5 0.1 5.9e-86 288.1 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDK36420.2 - 6.1e-09 35.9 2.0 1.3e-08 34.9 2.0 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF2458 PF10454.9 EDK36421.1 - 1.1e-12 48.0 1.4 1.5e-12 47.5 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Spectrin PF00435.21 EDK36421.1 - 0.07 13.6 1.6 0.17 12.4 1.5 1.8 1 1 0 1 1 1 0 Spectrin repeat Phage_Mu_Gam PF07352.12 EDK36421.1 - 0.088 12.7 11.0 2.4 8.1 0.1 3.1 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein vATP-synt_E PF01991.18 EDK36421.1 - 0.21 11.0 8.5 0.57 9.5 5.6 2.0 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit ILVD_EDD PF00920.21 EDK36422.2 - 4.5e-211 702.0 0.1 5.3e-211 701.7 0.1 1.1 1 0 0 1 1 1 1 Dehydratase family UQ_con PF00179.26 EDK36423.2 - 2.1e-35 121.4 0.2 4e-35 120.5 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme NPV_P10 PF05531.12 EDK36423.2 - 0.41 11.2 13.2 5.2 7.6 0.7 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TF_AP-2 PF03299.14 EDK36423.2 - 1.1 9.2 8.7 0.11 12.5 3.2 2.0 1 1 1 2 2 2 0 Transcription factor AP-2 Ribosomal_S28e PF01200.18 EDK36424.1 - 6.5e-33 112.5 1.9 7.2e-33 112.4 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e EB1 PF03271.17 EDK36425.2 - 4.2e-14 52.5 1.4 4.6e-14 52.4 0.2 1.8 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EDK36425.2 - 7.8e-08 32.5 0.8 1e-07 32.1 0.2 1.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 EDK36425.2 - 0.09 12.9 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 CH-like domain in sperm protein zf-C2HE PF16278.5 EDK36426.2 - 0.0066 16.9 0.2 0.013 15.9 0.2 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_2 PF13465.6 EDK36426.2 - 0.024 15.0 1.6 2.9 8.5 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.26 EDK36426.2 - 0.027 14.9 0.3 0.079 13.4 0.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDK36426.2 - 0.067 13.5 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding PET117 PF15786.5 EDK36427.2 - 6.7e-26 90.3 0.5 7.8e-26 90.1 0.5 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial Mei5 PF10376.9 EDK36427.2 - 0.018 14.9 1.3 0.02 14.8 1.3 1.1 1 0 0 1 1 1 0 Double-strand recombination repair protein DUF896 PF05979.12 EDK36427.2 - 0.065 13.1 3.1 0.065 13.1 3.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) Cyclin PF08613.11 EDK36428.2 - 1.9e-42 145.4 0.3 1.9e-42 145.4 0.3 1.6 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EDK36428.2 - 0.055 13.2 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain RTA1 PF04479.13 EDK36429.2 - 1.7e-62 210.7 12.2 1.7e-62 210.7 12.2 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF308 PF03729.13 EDK36429.2 - 3.3 8.1 11.6 1.7 9.0 3.9 2.9 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) RTA1 PF04479.13 EDK36430.2 - 6.3e-40 137.0 13.3 9.1e-40 136.5 13.3 1.2 1 0 0 1 1 1 1 RTA1 like protein CNOT11 PF10155.9 EDK36431.2 - 0.012 15.8 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 WD40 PF00400.32 EDK36432.2 - 5.9e-07 30.1 6.4 0.25 12.3 0.0 5.9 6 1 0 6 6 6 2 WD domain, G-beta repeat Sec16_C PF12931.7 EDK36432.2 - 0.00033 20.4 0.8 0.0013 18.4 0.4 2.2 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 EDK36432.2 - 0.15 12.1 0.1 1.3 9.0 0.1 2.3 1 1 1 2 2 2 0 Prp18 domain Dynactin PF12455.8 EDK36432.2 - 0.15 11.3 0.1 0.26 10.5 0.1 1.3 1 0 0 1 1 1 0 Dynein associated protein SRA1 PF07304.11 EDK36432.2 - 1 9.1 7.8 0.071 12.9 0.4 3.0 2 1 0 2 2 2 0 Steroid receptor RNA activator (SRA1) Glyco_hydro_65m PF03632.15 EDK36433.2 - 7.8e-39 133.6 2.8 3e-31 108.6 1.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 EDK36433.2 - 1.6e-24 86.8 0.0 2.7e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain F5_F8_type_C PF00754.25 EDK36433.2 - 0.0024 18.0 0.1 0.01 15.9 0.1 2.1 2 0 0 2 2 2 1 F5/8 type C domain Glyco_hydro_65C PF03633.15 EDK36433.2 - 0.051 13.5 0.0 0.19 11.7 0.0 2.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain MIS13 PF08202.11 EDK36434.2 - 2e-57 194.8 5.6 2e-57 194.8 5.6 2.1 2 1 0 2 2 2 1 Mis12-Mtw1 protein family SAVED PF18145.1 EDK36434.2 - 0.08 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain Tup_N PF08581.10 EDK36434.2 - 0.28 11.5 3.6 0.32 11.3 0.6 2.6 2 0 0 2 2 2 0 Tup N-terminal MRP-S33 PF08293.11 EDK36436.1 - 1.5e-30 105.2 1.3 1.7e-30 105.0 1.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ion_trans PF00520.31 EDK36437.2 - 6e-119 395.7 109.8 8.1e-38 130.0 9.7 5.2 5 0 0 5 5 5 5 Ion transport protein GPHH PF16905.5 EDK36437.2 - 0.035 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated DUF4407 PF14362.6 EDK36437.2 - 0.079 12.3 0.2 0.23 10.8 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_11_kDa PF06143.11 EDK36437.2 - 0.11 12.1 13.8 0.18 11.4 0.2 4.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family PspB PF06667.12 EDK36437.2 - 0.36 10.9 5.0 13 5.9 0.1 3.8 3 0 0 3 3 3 0 Phage shock protein B zf-ZPR1 PF03367.13 EDK36438.1 - 5.7e-118 390.3 0.2 2.7e-59 199.6 0.0 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EDK36438.1 - 0.0029 17.6 4.1 1.3 9.1 0.6 2.7 3 0 0 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SF-assemblin PF06705.11 EDK36438.1 - 0.13 11.6 2.7 7.4 5.8 0.0 2.6 3 0 0 3 3 3 0 SF-assemblin/beta giardin zinc_ribbon_4 PF13717.6 EDK36438.1 - 0.19 11.7 3.6 6.4 6.8 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Cytochrom_C_2 PF01322.20 EDK36438.1 - 1.3 9.9 8.5 8.3 7.3 0.2 3.8 5 0 0 5 5 5 0 Cytochrome C' DZR PF12773.7 EDK36438.1 - 4.2 7.5 11.0 7.1 6.7 0.8 3.4 2 1 1 3 3 3 0 Double zinc ribbon Rubredoxin_2 PF18073.1 EDK36438.1 - 5 7.0 8.6 4 7.2 0.3 3.1 3 0 0 3 3 3 0 Rubredoxin metal binding domain WD40 PF00400.32 EDK36439.2 - 3.1e-40 135.4 32.7 9.4e-07 29.5 0.1 8.4 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EDK36439.2 - 3e-13 49.4 1.4 5.8e-13 48.5 1.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK36439.2 - 7.6e-12 44.8 2.2 1.5e-11 43.9 1.4 2.0 1 1 1 2 2 2 1 F-box domain Nup160 PF11715.8 EDK36439.2 - 1.2e-11 43.9 17.0 0.02 13.5 0.4 6.2 2 2 3 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 EDK36439.2 - 1.3e-06 28.0 0.8 0.00023 20.6 0.7 2.2 2 0 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EDK36439.2 - 1.5e-06 28.4 5.0 0.77 10.1 0.0 5.3 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EDK36439.2 - 1.8e-06 27.9 0.1 0.0073 16.3 0.0 4.1 2 2 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EDK36439.2 - 0.0004 20.3 0.5 0.2 11.5 0.0 2.8 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A F-box_4 PF15966.5 EDK36439.2 - 0.0013 18.6 0.6 0.0065 16.3 0.0 2.6 2 0 0 2 2 2 1 F-box DUF2072 PF09845.9 EDK36439.2 - 0.0092 16.2 0.8 0.025 14.8 0.5 1.8 2 0 0 2 2 2 1 Zn-ribbon containing protein HCMV_UL124 PF17609.2 EDK36439.2 - 0.043 14.0 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function CBM_21 PF03370.13 EDK36440.2 - 4e-36 123.6 1.7 8.2e-36 122.6 1.7 1.5 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EDK36440.2 - 0.00032 21.2 2.8 0.0031 18.1 2.8 2.3 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) LCM PF04072.14 EDK36441.2 - 9.4e-25 87.6 0.0 1.7e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 EDK36441.2 - 4.8e-17 61.7 0.3 3.3e-09 36.6 0.0 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EDK36441.2 - 2.8e-11 43.4 0.0 0.00086 19.5 0.0 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EDK36441.2 - 2.3e-08 33.8 0.0 0.23 11.5 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EDK36441.2 - 3.3e-05 24.0 4.8 7.9 6.9 0.0 5.5 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.25 EDK36441.2 - 0.0062 16.1 0.2 13 5.5 0.0 4.8 5 0 0 5 5 5 1 Kelch motif PDZ_1 PF12812.7 EDK36441.2 - 0.03 14.4 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 PDZ-like domain Kelch_2 PF07646.15 EDK36441.2 - 0.13 12.3 5.5 13 5.9 0.0 4.9 5 1 1 6 6 6 0 Kelch motif KH_6 PF15985.5 EDK36442.2 - 5e-14 52.4 0.1 1e-13 51.4 0.1 1.6 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EDK36442.2 - 1.1e-08 34.8 0.0 2.2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Zn_clus PF00172.18 EDK36443.2 - 3.6e-08 33.4 9.9 6.7e-08 32.5 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MTBP_C PF14920.6 EDK36444.2 - 0.089 12.5 1.6 0.12 12.1 1.6 1.2 1 0 0 1 1 1 0 MDM2-binding APH PF01636.23 EDK36445.2 - 3.7e-08 33.6 0.0 1.8e-07 31.3 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDK36445.2 - 0.11 11.8 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1773 PF08593.10 EDK36445.2 - 0.12 13.4 0.3 6.4 7.9 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function Sedlin_N PF04628.13 EDK36446.2 - 3.1e-48 163.2 0.0 3.5e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EDK36446.2 - 7.2e-05 22.7 0.2 0.00018 21.5 0.2 1.8 1 1 0 1 1 1 1 Sybindin-like family SSXT PF05030.12 EDK36447.2 - 0.062 12.9 0.5 4.7 6.9 0.1 2.5 2 0 0 2 2 2 0 SSXT protein (N-terminal region) DAHP_synth_1 PF00793.20 EDK36448.2 - 2.9e-16 59.2 0.0 4.6e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 DAHP synthetase I family PITH PF06201.13 EDK36450.2 - 1.7e-26 93.3 0.1 2.7e-26 92.6 0.1 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EDK36450.2 - 3.3e-22 78.4 0.1 9e-22 77.0 0.1 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EDK36450.2 - 3.3e-09 36.9 0.0 5.7e-07 29.8 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDK36450.2 - 3.1e-07 30.8 0.2 1.2e-06 28.9 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EDK36450.2 - 2.6e-06 27.4 0.1 9.8e-06 25.5 0.1 2.1 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EDK36450.2 - 5.2e-05 23.0 0.0 0.0001 22.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EDK36450.2 - 0.00019 21.2 0.1 0.00051 19.8 0.1 1.7 1 1 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EDK36450.2 - 0.00037 20.6 0.1 0.001 19.2 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EDK36450.2 - 0.00064 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 EDK36450.2 - 0.0013 18.1 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EDK36450.2 - 0.004 17.3 1.3 0.0073 16.5 0.2 2.0 2 0 0 2 2 2 1 Glutaredoxin DUF836 PF05768.14 EDK36450.2 - 0.019 15.4 0.1 0.045 14.2 0.1 1.6 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 EDK36450.2 - 0.021 14.9 0.1 0.043 13.9 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin domain HyaE PF07449.11 EDK36450.2 - 0.067 13.2 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 EDK36450.2 - 0.12 12.0 0.1 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin LETM1 PF07766.13 EDK36451.2 - 4.5e-100 334.4 4.5 4.5e-100 334.4 4.5 1.5 2 0 0 2 2 2 1 LETM1-like protein dUTPase PF00692.19 EDK36452.1 - 1.8e-44 150.5 0.1 2.1e-44 150.3 0.1 1.0 1 0 0 1 1 1 1 dUTPase HMG_box PF00505.19 EDK36453.2 - 3.5e-05 24.1 4.9 0.22 11.9 1.7 3.7 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDK36453.2 - 0.0012 19.4 0.9 2.1 9.0 0.2 3.6 3 0 0 3 3 3 2 HMG-box domain DEAD PF00270.29 EDK36455.1 - 5.3e-46 156.6 0.8 9.3e-46 155.8 0.8 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK36455.1 - 7.9e-33 113.1 0.7 5.8e-31 107.1 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK36455.1 - 2.3e-08 34.2 0.0 3.9e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDK36455.1 - 0.00014 22.2 0.6 0.00027 21.3 0.2 1.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK36455.1 - 0.00024 20.9 0.1 0.00039 20.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDK36455.1 - 0.0056 17.0 0.1 0.016 15.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EDK36455.1 - 0.0069 15.7 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 EDK36455.1 - 0.011 15.7 0.2 0.14 12.2 0.2 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain UvrD-helicase PF00580.21 EDK36455.1 - 0.072 12.6 0.8 0.22 11.0 0.4 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain TniB PF05621.11 EDK36455.1 - 0.092 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Glyco_transf_8 PF01501.20 EDK36456.2 - 4.1e-20 72.4 2.1 1.4e-12 47.7 0.2 3.0 2 1 0 2 2 2 2 Glycosyl transferase family 8 tRNA_U5-meth_tr PF05958.11 EDK36457.2 - 3.5e-25 88.8 1.0 2.3e-24 86.1 1.0 2.0 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 EDK36457.2 - 2.2e-10 40.4 0.0 5.4e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 TRAM domain Methyltransf_31 PF13847.6 EDK36457.2 - 1.3e-08 34.8 0.1 2.6e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36457.2 - 4.3e-07 30.6 0.0 1.1e-06 29.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EDK36457.2 - 8.3e-06 25.5 0.2 1.8e-05 24.4 0.2 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EDK36457.2 - 6e-05 22.6 0.4 0.0001 21.8 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDK36457.2 - 0.00011 21.8 0.1 0.00021 20.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EDK36457.2 - 0.0002 21.9 0.0 0.00054 20.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EDK36457.2 - 0.00022 21.0 0.2 0.00039 20.2 0.2 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Ubie_methyltran PF01209.18 EDK36457.2 - 0.00045 19.6 0.1 0.0011 18.4 0.1 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EDK36457.2 - 0.0057 16.1 0.1 0.015 14.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_23 PF13489.6 EDK36457.2 - 0.028 14.2 0.0 0.064 13.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain PAP2 PF01569.21 EDK36458.2 - 1.2e-22 80.1 2.5 1.2e-22 80.1 2.5 2.1 2 0 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EDK36458.2 - 0.12 12.5 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 Divergent PAP2 family PAP2_3 PF14378.6 EDK36458.2 - 0.98 9.1 13.6 0.1 12.3 6.6 2.8 2 1 0 2 2 2 0 PAP2 superfamily Ras PF00071.22 EDK36459.2 - 4.2e-46 156.5 0.0 6e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK36459.2 - 6.8e-22 77.9 0.0 1.1e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK36459.2 - 4e-06 26.4 0.0 6.8e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 EDK36459.2 - 0.051 13.8 0.4 0.47 10.7 0.1 2.5 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 EDK36459.2 - 0.094 12.2 0.1 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 EDK36459.2 - 0.13 11.5 0.0 0.29 10.3 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain DUF2401 PF10287.9 EDK36461.1 - 1.4e-94 316.0 1.9 3.4e-94 314.7 1.9 1.7 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDK36461.1 - 6.2e-28 97.0 0.1 2.3e-27 95.2 0.1 2.1 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) AF-4 PF05110.13 EDK36461.1 - 0.11 10.6 11.3 0.18 9.8 11.3 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FGGY_C PF02782.16 EDK36462.2 - 1e-15 58.0 0.0 1.6e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDK36462.2 - 1.6e-15 57.3 0.0 2.5e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EDK36462.2 - 0.0049 16.4 0.0 0.038 13.5 0.0 2.1 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Zn_clus PF00172.18 EDK36463.2 - 4.9e-06 26.6 17.9 7.9e-06 25.9 17.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.28 EDK36464.1 - 3.8e-32 112.5 0.3 5.9e-32 111.8 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ChpA-C PF03777.13 EDK36464.1 - 0.41 10.6 1.3 0.88 9.5 1.3 1.5 1 0 0 1 1 1 0 ChpA-C NAD_binding_10 PF13460.6 EDK36465.1 - 2.7e-13 50.2 0.0 4.7e-13 49.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK36465.1 - 1.2e-12 47.9 0.2 3.1e-12 46.5 0.1 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDK36465.1 - 7.2e-12 45.4 0.0 1.2e-11 44.7 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EDK36465.1 - 2.4e-09 36.6 0.1 4.3e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDK36465.1 - 1.1e-05 24.7 0.0 0.00032 19.9 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EDK36465.1 - 0.0011 19.2 0.0 0.0034 17.6 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EDK36465.1 - 0.0095 15.1 0.6 6.2 5.9 0.0 2.9 1 1 2 3 3 3 2 Male sterility protein OHCU_decarbox PF09349.10 EDK36466.2 - 8.5e-40 136.8 0.0 1e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase ATP-synt_ab PF00006.25 EDK36467.1 - 2.7e-114 380.1 0.0 3.9e-114 379.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EDK36467.1 - 3.1e-45 153.0 0.0 6e-45 152.0 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EDK36467.1 - 4e-15 56.1 1.9 1e-14 54.8 1.9 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.6 EDK36467.1 - 0.016 15.2 0.0 0.13 12.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mit_KHE1 PF10173.9 EDK36469.1 - 1.5e-63 214.4 0.4 2.2e-63 213.8 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related MARVEL PF01284.23 EDK36470.2 - 1.5e-05 25.1 4.1 1.5e-05 25.1 4.1 1.9 2 0 0 2 2 2 1 Membrane-associating domain Cullin PF00888.22 EDK36471.2 - 8.3e-151 503.6 16.1 8.3e-151 503.6 16.1 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EDK36471.2 - 8.5e-24 83.4 4.3 8.5e-24 83.4 4.3 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain DltD PF04914.12 EDK36471.2 - 0.0049 16.3 1.3 0.0049 16.3 1.3 3.4 4 1 0 4 4 4 1 DltD protein DUF5344 PF17279.2 EDK36471.2 - 0.67 10.6 7.3 0.27 11.8 1.7 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) WD40 PF00400.32 EDK36472.2 - 7.8e-22 77.2 13.0 0.01 16.7 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 EDK36472.2 - 0.042 12.5 1.3 2.2 6.8 0.1 2.7 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF5046 PF16465.5 EDK36472.2 - 0.082 12.3 0.4 0.28 10.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) SNF2_N PF00176.23 EDK36473.2 - 4.8e-42 143.9 0.0 1.1e-40 139.4 0.0 2.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK36473.2 - 6.5e-11 42.6 0.0 7.8e-09 35.9 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain BRO1 PF03097.18 EDK36474.2 - 4.8e-118 394.4 8.6 1.1e-117 393.2 8.6 1.6 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDK36474.2 - 5e-24 85.1 11.9 5e-24 85.1 11.9 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV partial_CstF PF15861.5 EDK36474.2 - 0.05 13.4 0.0 0.16 11.8 0.0 1.9 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain DUF3958 PF13125.6 EDK36474.2 - 0.21 11.8 6.1 2.3 8.4 0.1 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3958) Glyco_hydro_16 PF00722.21 EDK36475.2 - 7e-45 152.7 7.5 7e-45 152.7 7.5 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 EDK36475.2 - 0.047 14.2 13.3 0.094 13.2 13.3 1.4 1 0 0 1 1 1 0 Chitin recognition protein Nodulin_late PF07127.11 EDK36475.2 - 0.18 12.2 0.8 0.31 11.4 0.8 1.4 1 0 0 1 1 1 0 Late nodulin protein Coatomer_WDAD PF04053.14 EDK36476.2 - 9.6e-143 476.4 6.2 1.7e-142 475.6 6.2 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EDK36476.2 - 3.2e-94 316.0 0.0 4.7e-94 315.4 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EDK36476.2 - 4e-39 131.9 19.4 4.7e-08 33.6 0.7 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36476.2 - 5e-10 39.6 1.4 0.0031 17.8 0.0 5.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK36476.2 - 0.0013 17.5 7.7 0.36 9.4 0.2 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EDK36476.2 - 0.092 12.6 0.2 1.7 8.5 0.1 2.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Metallophos PF00149.28 EDK36477.2 - 6e-31 108.5 0.0 9.6e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EDK36477.2 - 1.3e-26 92.7 2.1 3.7e-26 91.3 0.7 2.3 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 EDK36477.2 - 1.1e-20 72.5 5.2 3.7e-07 29.7 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDK36477.2 - 2e-16 58.7 2.5 3.5e-05 23.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDK36477.2 - 1e-12 47.5 0.9 9.9e-09 34.7 0.0 3.1 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 EDK36477.2 - 3e-10 39.5 4.6 0.0079 16.3 0.0 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK36477.2 - 4e-09 36.2 0.1 3.3e-05 23.9 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36477.2 - 1.1e-06 29.1 0.0 6.5e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36477.2 - 2.5e-06 27.9 0.0 0.012 16.0 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDK36477.2 - 0.00034 21.2 0.0 0.09 13.6 0.0 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK36477.2 - 0.001 19.3 0.5 2.3 8.6 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 EDK36477.2 - 0.0061 16.6 3.4 2.5 8.2 0.1 3.3 2 1 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 EDK36477.2 - 0.026 14.6 0.0 1.2 9.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NigD_C PF17415.2 EDK36477.2 - 0.06 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 NigD-like C-terminal beta sandwich domain Fis1_TPR_C PF14853.6 EDK36477.2 - 0.074 13.1 0.1 7.3 6.7 0.0 3.3 2 1 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat PG_binding_4 PF12229.8 EDK36477.2 - 0.082 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain TPR_6 PF13174.6 EDK36477.2 - 0.11 13.2 0.4 7.3 7.5 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDK36477.2 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK36477.2 - 0.22 11.8 2.7 0.24 11.7 0.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 CHCH PF06747.13 EDK36478.1 - 1.6e-07 31.3 5.9 3e-07 30.4 5.9 1.5 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EDK36478.1 - 0.0001 22.2 4.8 0.0018 18.3 1.0 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EDK36478.1 - 0.14 12.2 7.5 0.26 11.3 7.5 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like NAR2 PF16974.5 EDK36478.1 - 0.2 11.1 2.7 0.21 11.0 2.7 1.1 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Scm3 PF10384.9 EDK36479.2 - 2.3e-21 75.2 0.5 4e-21 74.5 0.5 1.4 1 0 0 1 1 1 1 Centromere protein Scm3 zf-C2H2_4 PF13894.6 EDK36479.2 - 0.08 13.8 11.1 16 6.7 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger NAM PF02365.15 EDK36480.2 - 0.027 15.4 0.1 0.039 14.9 0.1 1.3 1 0 0 1 1 1 0 No apical meristem (NAM) protein Peptidase_M41 PF01434.18 EDK36481.2 - 8.3e-66 221.5 0.1 1.7e-65 220.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDK36481.2 - 7.4e-43 146.1 0.1 2.4e-42 144.5 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK36481.2 - 1.6e-09 37.4 2.1 1.6e-09 37.4 0.4 2.0 2 0 0 2 2 2 1 AAA+ lid domain TIP49 PF06068.13 EDK36481.2 - 0.0022 17.3 0.0 0.0049 16.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDK36481.2 - 0.005 17.1 0.7 0.74 10.1 0.1 3.0 4 0 0 4 4 3 1 AAA domain RuvB_N PF05496.12 EDK36481.2 - 0.0079 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDK36481.2 - 0.01 16.2 1.4 0.077 13.4 0.2 2.9 3 1 0 3 3 3 0 AAA ATPase domain AAA_5 PF07728.14 EDK36481.2 - 0.013 15.5 0.7 0.051 13.6 0.1 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDK36481.2 - 0.021 14.6 0.1 0.098 12.4 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein CARD PF00619.21 EDK36481.2 - 0.044 13.8 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Caspase recruitment domain AAA_17 PF13207.6 EDK36481.2 - 0.046 14.2 1.6 0.11 12.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain REC1 PF18501.1 EDK36481.2 - 0.075 12.9 6.6 0.076 12.9 1.5 2.5 2 0 0 2 2 2 0 Alpha helical recognition lobe domain AAA_2 PF07724.14 EDK36481.2 - 0.087 12.9 0.0 0.087 12.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDK36481.2 - 0.14 12.3 0.1 0.46 10.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain Glyco_transf_15 PF01793.16 EDK36483.2 - 4.6e-133 443.5 9.3 5.7e-133 443.2 9.3 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Glyco_transf_15 PF01793.16 EDK36484.2 - 1.8e-130 434.9 11.6 2.3e-130 434.6 11.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase RabGAP-TBC PF00566.18 EDK36485.2 - 7.6e-33 114.0 0.7 1e-32 113.5 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NPL4 PF05021.15 EDK36486.2 - 2.7e-127 424.3 0.0 3.6e-127 424.0 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EDK36486.2 - 3.4e-67 225.1 0.6 5.7e-67 224.4 0.6 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EDK36486.2 - 2.5e-06 27.8 0.0 6.5e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 HSP70 PF00012.20 EDK36487.1 - 1.3e-144 482.6 0.0 1.6e-144 482.4 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDK36487.1 - 3.9e-13 48.9 0.1 2.1e-12 46.5 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein HSP70 PF00012.20 EDK36488.1 - 2.9e-12 45.6 2.4 2.9e-12 45.6 2.4 1.7 1 1 1 2 2 2 1 Hsp70 protein DUF5415 PF17436.2 EDK36488.1 - 0.003 17.6 1.5 0.0071 16.4 1.5 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5415) Trans_reg_C PF00486.28 EDK36488.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal Pkinase PF00069.25 EDK36489.2 - 4.3e-43 147.6 0.7 1e-22 80.8 0.5 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36489.2 - 8.5e-17 61.3 2.0 4.8e-11 42.4 0.7 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pex14_N PF04695.13 EDK36489.2 - 0.11 13.1 4.5 0.31 11.7 4.5 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM176 PF14851.6 EDK36489.2 - 0.22 11.2 7.1 4.6 6.9 1.8 2.3 2 0 0 2 2 2 0 FAM176 family DUF3246 PF11596.8 EDK36489.2 - 2.8 7.3 9.3 0.12 11.8 3.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) DUF4746 PF15928.5 EDK36489.2 - 3.2 7.1 8.6 10 5.5 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Sporozoite_P67 PF05642.11 EDK36489.2 - 3.5 5.6 9.3 0.44 8.6 1.5 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Radical_SAM_C PF16199.5 EDK36490.2 - 2.3e-25 88.4 0.1 4.8e-25 87.4 0.1 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EDK36490.2 - 1.8e-18 67.5 0.1 3e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily MBA1 PF07961.11 EDK36491.2 - 6.8e-73 244.6 0.0 8.4e-73 244.3 0.0 1.0 1 0 0 1 1 1 1 MBA1-like protein zf-CCCH_4 PF18044.1 EDK36492.2 - 6.8e-06 25.8 2.7 1.2e-05 24.9 2.7 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EDK36492.2 - 0.00029 20.7 1.6 0.00048 20.0 1.6 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EDK36492.2 - 0.0011 19.6 0.1 0.0024 18.6 0.1 1.5 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 EDK36492.2 - 0.038 14.0 6.6 0.074 13.1 6.6 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_2 PF14608.6 EDK36492.2 - 0.56 10.8 3.0 0.99 10.0 3.0 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger NOG1_N PF17835.1 EDK36493.1 - 1.1e-49 168.4 0.2 1.1e-49 168.4 0.2 2.1 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EDK36493.1 - 4.7e-26 90.5 1.8 1.5e-25 88.9 1.8 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EDK36493.1 - 1.2e-25 89.0 1.5 1.6e-25 88.7 0.2 1.9 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EDK36493.1 - 1.7e-15 57.1 0.0 5e-15 55.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK36493.1 - 3.1e-09 36.6 0.0 7e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDK36493.1 - 0.0072 16.4 0.0 3.5 7.7 0.0 3.0 1 1 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 EDK36493.1 - 0.0095 15.8 0.0 3.3 7.6 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK36493.1 - 0.071 13.5 0.0 0.37 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 EDK36493.1 - 0.093 12.9 0.1 0.43 10.8 0.0 2.2 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Anp1 PF03452.14 EDK36494.2 - 5.7e-107 357.0 0.0 6.9e-107 356.8 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EDK36494.2 - 0.018 14.8 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 Macoilin PF09726.9 EDK36494.2 - 0.025 13.2 1.1 0.032 12.8 1.1 1.0 1 0 0 1 1 1 0 Macoilin family FtsH_ext PF06480.15 EDK36494.2 - 0.046 14.1 0.2 0.078 13.3 0.2 1.5 1 1 0 1 1 1 0 FtsH Extracellular Zn_clus PF00172.18 EDK36496.2 - 7.6e-06 25.9 12.4 1.4e-05 25.2 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_1 PF00076.22 EDK36497.2 - 0.016 15.0 0.0 3.1 7.7 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.15 EDK36497.2 - 0.024 14.3 0.8 0.1 12.4 0.8 2.1 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Flavoprotein PF02441.19 EDK36498.2 - 2e-49 167.4 0.1 2.8e-49 166.9 0.1 1.2 1 0 0 1 1 1 1 Flavoprotein PPP4R2 PF09184.11 EDK36498.2 - 0.0004 20.1 4.4 0.0004 20.1 4.4 2.4 2 1 1 3 3 3 1 PPP4R2 DUF2457 PF10446.9 EDK36498.2 - 0.0058 15.8 31.5 0.0058 15.8 31.5 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2457) RRN3 PF05327.11 EDK36498.2 - 0.049 12.2 11.7 0.076 11.6 11.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EDK36498.2 - 0.21 9.9 15.4 0.7 8.1 15.8 1.6 2 0 0 2 2 2 0 CDC45-like protein SDA1 PF05285.12 EDK36498.2 - 3 7.2 21.6 6.9 6.0 21.6 1.5 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EDK36498.2 - 8.2 4.5 22.0 13 3.8 22.0 1.2 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 EDK36498.2 - 8.6 5.0 7.7 0.53 9.0 2.3 1.6 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein MAP65_ASE1 PF03999.12 EDK36499.2 - 3.2e-52 178.1 43.3 3.2e-52 178.1 43.3 2.3 2 1 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) GIT1_C PF12205.8 EDK36499.2 - 0.035 14.2 3.2 2.1 8.5 0.0 3.9 3 1 1 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term Carbpep_Y_N PF05388.11 EDK36499.2 - 2 9.0 7.6 0.29 11.7 0.5 3.3 3 0 0 3 3 3 0 Carboxypeptidase Y pro-peptide DnaT PF17948.1 EDK36500.2 - 0.094 12.4 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 DnaT DNA-binding domain PQ-loop PF04193.14 EDK36501.2 - 1.2e-37 127.5 13.7 8.8e-20 70.2 2.0 3.3 3 0 0 3 3 3 2 PQ loop repeat DUF3481 PF11980.8 EDK36501.2 - 0.082 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein MtN3_slv PF03083.16 EDK36501.2 - 0.19 11.8 0.1 0.19 11.8 0.1 3.0 2 1 1 3 3 3 0 Sugar efflux transporter for intercellular exchange ER_lumen_recept PF00810.18 EDK36501.2 - 1.1 10.1 0.1 1.1 10.1 0.1 3.1 2 2 1 3 3 3 0 ER lumen protein retaining receptor Pyridoxal_deC PF00282.19 EDK36502.2 - 2.1e-18 66.2 0.0 3.5e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDK36502.2 - 1.7e-08 33.8 0.0 1.4e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDK36502.2 - 4e-08 33.0 0.0 6.2e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDK36502.2 - 0.00029 19.5 0.0 0.00047 18.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SepSecS PF05889.13 EDK36502.2 - 0.032 12.9 0.0 0.17 10.6 0.0 1.8 2 0 0 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS HDA2-3 PF11496.8 EDK36503.2 - 1.4e-76 257.5 0.5 1.4e-76 257.5 0.5 1.9 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 TLE_N PF03920.15 EDK36503.2 - 0.036 14.1 2.4 0.73 9.9 2.7 2.6 2 0 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain UvrA_inter PF17760.1 EDK36503.2 - 0.64 10.1 6.4 0.12 12.5 1.8 2.2 2 1 0 2 2 2 0 UvrA interaction domain PBP_dimer PF03717.15 EDK36503.2 - 1.9 8.8 8.7 1.2 9.5 6.5 1.8 2 0 0 2 2 2 0 Penicillin-binding Protein dimerisation domain HIP1_clath_bdg PF16515.5 EDK36503.2 - 1.9 9.1 13.9 0.7 10.5 9.7 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cnn_1N PF07989.11 EDK36503.2 - 5.1 7.3 16.7 0.053 13.7 6.6 2.9 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Nup54 PF13874.6 EDK36503.2 - 8.6 6.5 11.8 3.3 7.8 2.7 3.1 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 BLOC1_2 PF10046.9 EDK36503.2 - 9.7 6.6 17.0 0.56 10.5 4.2 3.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 EF-hand_4 PF12763.7 EDK36504.2 - 4.7e-06 26.5 0.0 1.3e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EDK36504.2 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 EF hand PIN_6 PF17146.4 EDK36505.2 - 6.5e-31 106.7 1.3 1.2e-30 105.8 0.0 2.2 2 0 0 2 2 2 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EDK36505.2 - 3.1e-26 91.3 0.9 6.1e-26 90.4 0.9 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.10 EDK36505.2 - 0.0064 16.6 2.5 0.018 15.2 2.5 1.8 1 0 0 1 1 1 1 Zinc ribbon domain zinc_ribbon_9 PF14369.6 EDK36505.2 - 0.31 11.4 1.1 0.69 10.2 1.1 1.5 1 0 0 1 1 1 0 zinc-ribbon Presenilin PF01080.17 EDK36505.2 - 1.1 7.9 18.7 0.098 11.4 13.0 2.0 2 0 0 2 2 2 0 Presenilin Zn_Tnp_IS91 PF14319.6 EDK36505.2 - 1.7 8.8 4.3 0.46 10.5 0.3 2.2 2 0 0 2 2 2 0 Transposase zinc-binding domain Hydin_ADK PF17213.3 EDK36505.2 - 3 8.1 9.0 6.8 6.9 9.0 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF966 PF06136.13 EDK36505.2 - 6 6.5 17.4 1.8 8.2 14.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF966) TP53IP5 PF15331.6 EDK36505.2 - 9.7 6.3 16.2 24 5.0 16.2 1.6 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 GST_N PF02798.20 EDK36506.2 - 3.8e-12 46.4 0.0 7.6e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDK36506.2 - 4.6e-11 43.0 0.4 1.3e-10 41.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDK36506.2 - 5.7e-11 42.5 0.3 1.6e-10 41.1 0.3 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDK36506.2 - 1e-09 38.5 0.2 2.2e-09 37.4 0.1 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EDK36506.2 - 1.9e-08 34.5 0.0 4.3e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDK36506.2 - 1.3e-05 25.1 0.0 2.4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDK36506.2 - 0.0003 21.5 0.0 0.0006 20.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EDK36506.2 - 0.041 14.2 0.0 0.08 13.2 0.0 1.6 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein GST_C_5 PF16865.5 EDK36506.2 - 0.054 14.1 0.0 0.13 12.9 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDK36507.2 - 6.6e-11 42.3 0.0 5.7e-10 39.3 0.0 2.1 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDK36507.2 - 2.4e-09 37.3 0.0 1.8e-08 34.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDK36507.2 - 9.2e-08 32.0 0.0 1.3e-07 31.5 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EDK36507.2 - 0.033 14.8 0.0 0.075 13.6 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDK36507.2 - 0.045 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EDK36508.1 - 3.9e-06 27.1 0.0 7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDK36508.1 - 9.3e-06 26.0 0.0 1.8e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDK36508.1 - 2.4e-05 24.5 0.0 4.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDK36508.1 - 9.6e-05 22.3 0.0 0.00019 21.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDK36508.1 - 0.00018 21.7 0.0 0.00043 20.4 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EDK36508.1 - 0.0014 18.9 0.0 0.0024 18.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glyco_transf_15 PF01793.16 EDK36509.2 - 2e-124 415.1 12.4 2.6e-124 414.7 12.4 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase tRNA-synt_2 PF00152.20 EDK36510.2 - 9.7e-98 327.1 0.0 1.2e-97 326.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDK36510.2 - 9.8e-06 25.5 0.0 3.6e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain PUF PF00806.19 EDK36511.2 - 1.6e-23 81.0 5.1 0.0006 19.4 0.0 8.2 10 0 0 10 10 10 5 Pumilio-family RNA binding repeat PPTA PF01239.22 EDK36512.2 - 2.2e-12 46.3 5.7 7.8e-07 28.6 0.1 3.1 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat HORMA PF02301.18 EDK36513.2 - 6.6e-20 71.6 1.3 2.3e-19 69.8 1.3 1.7 1 1 0 1 1 1 1 HORMA domain Cyclin_N PF00134.23 EDK36514.2 - 8e-13 48.2 0.4 1.9e-12 47.0 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Porin_3 PF01459.22 EDK36515.1 - 7.8e-73 245.2 3.6 8.8e-73 245.1 3.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin Macro_2 PF14519.6 EDK36516.2 - 9.5e-16 58.0 0.0 1.5e-15 57.3 0.0 1.3 1 1 0 1 1 1 1 Macro-like domain Macro PF01661.21 EDK36516.2 - 0.01 15.8 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Macro domain Phage_P2_GpE PF06528.12 EDK36516.2 - 0.099 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Phage P2 GpE NUDIX PF00293.28 EDK36517.2 - 1.7e-12 47.5 0.1 2.2e-12 47.1 0.1 1.3 1 1 0 1 1 1 1 NUDIX domain BOP1NT PF08145.12 EDK36518.2 - 1.2e-106 356.5 10.5 2.1e-106 355.6 10.5 1.5 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EDK36518.2 - 9.2e-23 80.1 9.7 2.6e-09 37.6 0.3 6.5 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36518.2 - 2.5e-07 30.9 0.5 0.013 15.7 0.0 4.7 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK36518.2 - 0.014 14.1 0.0 0.035 12.7 0.0 1.6 1 0 0 1 1 1 0 Nucleoporin Nup120/160 RRM_1 PF00076.22 EDK36519.1 - 1e-17 63.7 0.0 2.2e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK36519.1 - 0.0039 17.3 0.0 0.012 15.7 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif DUF433 PF04255.14 EDK36519.1 - 0.016 15.0 0.1 0.057 13.3 0.0 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF433) US6 PF17616.2 EDK36519.1 - 0.056 13.4 0.5 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 Viral unique short region 6 CDC45 PF02724.14 EDK36519.1 - 0.99 7.6 8.3 1.2 7.3 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Acyltransferase PF01553.21 EDK36520.2 - 0.023 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase Histone_H2A_C PF16211.5 EDK36521.1 - 1.4e-19 69.5 1.4 2.5e-19 68.7 1.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDK36521.1 - 5e-17 62.5 0.0 6.3e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDK36521.1 - 4.2e-05 23.7 0.0 5.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK36522.1 - 3.4e-20 72.7 3.9 4.7e-20 72.3 3.9 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDK36522.1 - 1.7e-07 31.4 0.9 3.6e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDK36522.1 - 0.0015 19.0 0.0 0.0028 18.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EDK36522.1 - 0.0026 17.8 1.0 0.0033 17.5 1.0 1.2 1 0 0 1 1 1 1 YscO-like protein NFACT-R_2 PF18297.1 EDK36522.1 - 0.0048 17.1 0.1 0.0084 16.3 0.1 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain CENP-W PF15510.6 EDK36522.1 - 0.045 14.0 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 CENP-W protein DUF3391 PF11871.8 EDK36522.1 - 0.36 11.4 3.0 0.6 10.6 3.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) PGAP1 PF07819.13 EDK36523.2 - 1.9e-89 299.4 0.0 3.1e-89 298.7 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EDK36523.2 - 0.0011 18.6 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EDK36523.2 - 0.0017 19.0 0.0 0.0036 17.9 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDK36523.2 - 0.0028 17.3 0.0 0.014 15.1 0.0 1.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Palm_thioest PF02089.15 EDK36523.2 - 0.0043 16.9 0.0 0.01 15.7 0.0 1.6 2 0 0 2 2 2 1 Palmitoyl protein thioesterase LCAT PF02450.15 EDK36523.2 - 0.0064 15.7 0.0 0.41 9.8 0.0 2.2 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EDK36523.2 - 0.016 14.5 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 OAD_gamma PF04277.13 EDK36523.2 - 0.035 14.7 0.0 0.094 13.3 0.0 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GAIN_A PF18619.1 EDK36524.2 - 0.079 13.2 0.2 0.18 12.0 0.2 1.5 1 0 0 1 1 1 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A DUF3294 PF07957.11 EDK36525.2 - 1.7e-57 194.6 0.1 2.2e-57 194.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) Sec66 PF09802.9 EDK36526.2 - 8.4e-70 234.0 0.4 2e-69 232.8 0.4 1.6 2 0 0 2 2 2 1 Preprotein translocase subunit Sec66 SieB PF14163.6 EDK36526.2 - 0.073 12.6 0.6 0.46 10.0 0.0 2.3 2 0 0 2 2 2 0 Super-infection exclusion protein B Sec3_C PF09763.9 EDK36527.2 - 6.6e-181 603.2 32.3 6.6e-181 603.2 32.3 2.1 2 1 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EDK36527.2 - 1.1e-11 44.6 0.0 2.9e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH DUF5355 PF17306.2 EDK36528.2 - 4.3e-72 242.9 7.5 6.3e-72 242.4 7.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5355) BRO1 PF03097.18 EDK36528.2 - 0.0028 16.5 0.1 0.0072 15.2 0.1 1.6 1 1 0 1 1 1 1 BRO1-like domain GDA1_CD39 PF01150.17 EDK36529.1 - 4e-132 440.9 0.3 5.9e-132 440.3 0.3 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EDK36529.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family GN3L_Grn1 PF08701.11 EDK36530.2 - 6.4e-24 83.8 17.3 1.4e-23 82.8 17.3 1.6 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EDK36530.2 - 5.2e-19 68.4 0.4 7.3e-15 55.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK36530.2 - 3e-10 39.8 0.3 1.8e-08 34.0 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDK36530.2 - 4.7e-06 26.6 0.4 0.00013 21.9 0.4 2.3 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EDK36530.2 - 0.0011 19.1 8.0 0.5 10.4 0.0 3.9 2 2 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EDK36530.2 - 0.0011 18.6 3.6 0.054 13.0 0.0 3.0 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 EDK36530.2 - 0.0029 16.6 0.0 0.007 15.4 0.0 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EDK36530.2 - 0.0054 16.9 0.1 0.58 10.4 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EDK36530.2 - 0.01 16.3 0.5 0.063 13.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDK36530.2 - 0.023 14.3 0.1 1.2 8.7 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EDK36530.2 - 0.03 14.7 0.7 0.14 12.6 0.0 2.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EDK36530.2 - 0.033 13.6 0.0 0.078 12.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Nuc_deoxyri_tr2 PF15891.5 EDK36530.2 - 0.34 11.2 0.1 0.34 11.2 0.1 2.4 2 1 1 3 3 3 0 Nucleoside 2-deoxyribosyltransferase like AAA_16 PF13191.6 EDK36530.2 - 1.5 9.2 0.0 1.5 9.2 0.0 2.5 2 2 0 2 2 2 0 AAA ATPase domain CAP_GLY PF01302.25 EDK36531.2 - 3e-13 49.6 0.3 6.6e-13 48.5 0.3 1.6 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EDK36531.2 - 1.1e-09 38.4 13.5 0.12 12.8 0.0 5.5 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK36531.2 - 5.9e-07 29.1 6.3 0.029 14.1 2.3 3.9 2 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EDK36531.2 - 0.099 12.8 13.3 1.8 8.8 0.5 6.0 6 1 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 EDK36531.2 - 0.26 12.0 16.6 23 6.1 0.0 6.8 5 1 0 5 5 5 0 Leucine Rich Repeat Pre-PUA PF17832.1 EDK36532.1 - 2.7e-23 82.4 0.2 4.1e-23 81.9 0.2 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EDK36532.1 - 3.4e-18 65.4 0.0 5.1e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EDK36532.1 - 0.012 15.9 1.2 0.017 15.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Helicase_C PF00271.31 EDK36533.2 - 2.2e-17 63.4 0.1 6.5e-17 61.9 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GCIP PF13324.6 EDK36533.2 - 0.057 13.0 0.3 0.11 12.0 0.3 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting ResIII PF04851.15 EDK36535.1 - 1.3e-20 74.1 0.0 3.6e-20 72.7 0.0 1.6 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK36535.1 - 4e-18 65.8 0.0 5.3e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.23 EDK36535.1 - 4.1e-06 25.7 0.0 6.6e-06 25.1 0.0 1.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 EDK36535.1 - 7.2e-05 22.6 0.0 0.0001 22.1 0.0 1.2 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 EDK36535.1 - 0.0029 17.9 0.0 0.0095 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 EDK36535.1 - 0.065 12.7 0.0 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF5102 PF17104.5 EDK36535.1 - 0.065 13.3 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) NigD_N PF12667.7 EDK36535.1 - 0.1 12.7 0.4 0.68 10.1 0.1 2.2 2 0 0 2 2 2 0 NigD-like N-terminal OB domain MFS_1 PF07690.16 EDK36536.2 - 5.9e-18 64.9 22.2 2.9e-17 62.7 13.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3817 PF12823.7 EDK36536.2 - 2.1 9.2 13.3 11 6.9 6.4 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF3817) Phage_holin_3_6 PF07332.11 EDK36536.2 - 3.3 7.8 8.3 2.9 7.9 0.1 2.8 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1752 PF08550.10 EDK36537.2 - 0.031 14.1 1.0 0.031 14.1 1.0 2.5 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1752) Aa_trans PF01490.18 EDK36538.2 - 5.4e-79 265.8 38.0 6.5e-79 265.5 38.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EDK36538.2 - 0.00051 19.0 29.6 0.00051 19.0 29.6 2.2 1 1 0 2 2 2 2 Amino acid permease Fungal_trans PF04082.18 EDK36539.2 - 1.6e-32 112.6 1.8 2.8e-32 111.8 1.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK36539.2 - 2.6e-09 37.1 12.2 4.5e-09 36.3 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPP_enzyme_N PF02776.18 EDK36540.2 - 6e-27 94.3 0.0 1.2e-26 93.4 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDK36540.2 - 2.4e-23 82.4 0.0 7.4e-23 80.8 0.0 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDK36540.2 - 6.3e-18 65.0 0.0 2.1e-17 63.3 0.0 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EDK36540.2 - 0.061 12.5 0.0 0.16 11.1 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Alg6_Alg8 PF03155.15 EDK36541.2 - 2.1e-167 558.0 32.8 2.4e-167 557.8 32.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PMT_2 PF13231.6 EDK36541.2 - 2.2 8.5 22.4 0.11 12.7 4.9 3.1 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DEAD PF00270.29 EDK36542.1 - 1.8e-34 119.0 0.6 3.1e-34 118.3 0.6 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK36542.1 - 5.7e-26 91.0 0.0 1.5e-25 89.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Flavi_DEAD PF07652.14 EDK36542.1 - 0.00018 21.5 0.1 0.0004 20.4 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_22 PF13401.6 EDK36542.1 - 0.0043 17.3 0.4 0.048 13.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK36542.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDK36542.1 - 0.053 12.9 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein DEAD_2 PF06733.15 EDK36542.1 - 0.071 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 DEAD_2 Peptidase_A4 PF01828.17 EDK36542.1 - 0.079 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase A4 family Sod_Fe_C PF02777.18 EDK36543.2 - 1.3e-13 51.0 0.0 1.7e-07 31.3 0.0 2.3 1 1 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.11 EDK36544.2 - 2.4e-54 183.8 4.3 2.4e-54 183.8 4.3 2.5 2 1 0 2 2 2 1 Pal1 cell morphology protein DUF3915 PF13054.6 EDK36544.2 - 3.1 7.8 6.9 6.6 6.7 6.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Mitofilin PF09731.9 EDK36544.2 - 4.6 6.0 6.6 6.4 5.5 6.6 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FYVE PF01363.21 EDK36545.2 - 1.3e-14 54.1 7.9 2.2e-14 53.3 7.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger DUF1501 PF07394.12 EDK36545.2 - 0.72 8.8 2.2 1.1 8.3 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) IBR PF01485.21 EDK36545.2 - 4.3 7.6 12.5 1.1 9.6 7.2 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Pmp3 PF01679.17 EDK36546.1 - 2.2e-09 37.4 2.2 2.3e-09 37.3 2.2 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ACOX PF01756.19 EDK36547.2 - 2.5e-36 124.9 0.1 4.1e-36 124.2 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EDK36547.2 - 1.5e-22 79.6 0.1 3.5e-22 78.4 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EDK36547.2 - 2e-12 47.8 0.0 4.4e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EDK36547.2 - 0.00045 20.5 0.1 0.16 12.2 0.0 2.7 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain ACOX PF01756.19 EDK36548.2 - 7.3e-39 133.2 0.0 1.3e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EDK36548.2 - 5.4e-23 81.0 0.1 9.9e-23 80.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EDK36548.2 - 2.1e-15 57.4 0.0 4.2e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EDK36548.2 - 6.4e-06 26.5 0.3 0.00012 22.3 0.3 2.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Pyrid_oxidase_2 PF13883.6 EDK36549.1 - 5.1e-56 189.3 0.0 5.9e-56 189.1 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LRR_4 PF12799.7 EDK36550.2 - 7.4e-11 42.1 14.0 0.0011 19.3 0.2 6.5 5 1 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK36550.2 - 3.3e-07 29.8 7.7 6.9 7.0 0.1 7.4 8 0 0 8 8 8 2 Leucine Rich repeat LRR_8 PF13855.6 EDK36550.2 - 0.00014 21.5 12.0 0.11 12.3 0.3 5.4 4 3 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 EDK36550.2 - 0.00016 21.8 9.2 12 6.9 0.2 6.9 7 0 0 7 7 7 2 Leucine Rich Repeat DUF2716 PF10898.8 EDK36550.2 - 0.043 14.2 0.0 0.51 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2716) AAA_23 PF13476.6 EDK36551.2 - 6.8e-29 101.8 18.7 6.8e-29 101.8 18.7 7.8 1 1 2 3 3 1 1 AAA domain AAA_15 PF13175.6 EDK36551.2 - 8.2e-12 45.5 0.0 8.2e-12 45.5 0.0 4.7 1 1 2 3 3 1 1 AAA ATPase domain SMC_N PF02463.19 EDK36551.2 - 1.8e-09 37.4 22.5 1.4e-06 27.9 0.1 4.0 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK36551.2 - 2.4e-07 30.9 12.9 0.0028 17.5 0.1 4.2 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDK36551.2 - 3.8e-05 23.8 0.0 9.2e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit MscS_porin PF12795.7 EDK36551.2 - 0.0051 16.4 2.6 0.0051 16.4 2.6 8.1 4 2 1 6 6 6 2 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 EDK36551.2 - 0.015 15.1 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Plasmid_RAQPRD PF09686.10 EDK36551.2 - 0.022 14.9 0.5 0.022 14.9 0.5 6.9 6 2 1 7 7 7 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Rad50_zn_hook PF04423.14 EDK36551.2 - 0.031 14.1 0.0 0.031 14.1 0.0 4.6 3 0 0 3 3 3 0 Rad50 zinc hook motif Spidroin_MaSp PF11260.8 EDK36551.2 - 0.05 13.9 6.6 3.3 8.1 0.1 4.7 3 1 0 3 3 3 0 Major ampullate spidroin 1 and 2 AAA_16 PF13191.6 EDK36551.2 - 0.21 11.9 0.0 0.21 11.9 0.0 4.0 5 1 0 5 5 5 0 AAA ATPase domain Acyltransferase PF01553.21 EDK36552.2 - 2.2e-06 27.3 0.0 3.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EDK36552.2 - 0.0065 16.5 0.2 0.015 15.3 0.2 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus RRM_1 PF00076.22 EDK36553.2 - 4.4e-79 260.3 7.5 8.5e-17 60.7 0.1 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK36553.2 - 1.6e-09 37.5 0.1 0.081 12.5 0.0 4.8 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK36553.2 - 1.2e-06 28.4 1.5 0.77 9.8 0.0 5.5 6 0 0 6 6 6 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EDK36553.2 - 6e-05 22.8 0.0 6.2 6.8 0.0 4.8 4 0 0 4 4 4 2 Occluded RNA-recognition motif Neogenin_C PF06583.12 EDK36553.2 - 0.01 15.7 0.3 0.025 14.4 0.1 1.8 2 0 0 2 2 2 0 Neogenin C-terminus Rhomboid PF01694.22 EDK36554.2 - 7.8e-26 90.9 17.3 7.8e-26 90.9 17.3 1.6 1 1 0 1 1 1 1 Rhomboid family Sec23_trunk PF04811.15 EDK36556.2 - 1.1e-22 80.9 0.4 5.1e-16 59.0 0.0 3.0 3 0 0 3 3 3 2 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDK36556.2 - 8.7e-17 60.8 0.0 1.6e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDK36556.2 - 5.5e-10 39.1 2.5 2.3e-09 37.1 2.8 2.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EDK36556.2 - 7.1e-08 33.1 0.2 2e-07 31.6 0.2 1.8 1 1 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain DUF1749 PF08538.10 EDK36557.2 - 1.3e-93 313.3 0.0 1.5e-93 313.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EDK36557.2 - 6.9e-06 25.5 0.0 2.2e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EDK36557.2 - 9.6e-06 25.3 0.0 3.6e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EDK36557.2 - 0.00013 22.6 0.0 0.00016 22.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EDK36557.2 - 0.0021 17.7 0.0 0.046 13.3 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase LCAT PF02450.15 EDK36557.2 - 0.013 14.7 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Peptidase_S9 PF00326.21 EDK36557.2 - 0.019 14.5 0.0 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 EDK36557.2 - 0.036 13.9 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase FSH1 PF03959.13 EDK36557.2 - 0.064 12.9 0.0 0.23 11.1 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) SAM_2 PF07647.17 EDK36558.2 - 3.8e-09 36.5 0.0 9.2e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDK36558.2 - 2.3e-08 34.3 0.0 6.4e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EDK36558.2 - 0.11 12.5 0.1 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Ribosomal_L11_N PF03946.14 EDK36559.1 - 2.8e-22 78.3 0.2 6e-22 77.2 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EDK36559.1 - 2.6e-16 59.9 0.8 3.8e-16 59.3 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain ACBP PF00887.19 EDK36560.2 - 7.6e-09 35.7 0.1 1.5e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein ANAPC4_WD40 PF12894.7 EDK36561.2 - 5.6e-06 26.6 5.8 0.033 14.5 0.1 5.5 2 2 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK36561.2 - 8.5e-05 23.3 19.8 1 10.3 0.5 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.11 EDK36561.2 - 0.014 15.3 0.1 9.2 6.1 0.0 2.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF1921 PF09081.10 EDK36561.2 - 0.085 13.1 0.0 0.36 11.1 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1921) Glyco_hydro_76 PF03663.14 EDK36562.2 - 3.8e-42 145.1 0.8 5e-42 144.7 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EDK36562.2 - 0.00087 18.5 3.8 0.013 14.6 0.2 2.6 2 1 0 3 3 3 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EDK36562.2 - 0.0011 17.5 0.0 0.54 8.7 0.0 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 EDK36562.2 - 0.0018 17.8 0.1 0.13 11.8 0.0 2.5 2 0 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.11 EDK36562.2 - 0.0027 17.0 0.0 0.061 12.6 0.0 2.5 2 1 1 3 3 3 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Sterol_MT_C PF08498.10 EDK36563.2 - 1.8e-27 95.4 0.4 2.8e-27 94.8 0.4 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EDK36563.2 - 2e-17 63.6 0.0 3.9e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36563.2 - 2.5e-16 60.2 0.0 8e-16 58.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36563.2 - 1.6e-15 57.2 0.0 2.5e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDK36563.2 - 1.5e-11 44.1 0.9 2.2e-11 43.6 0.9 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDK36563.2 - 5.7e-11 43.0 0.0 1.1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK36563.2 - 7.3e-11 42.2 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK36563.2 - 4.5e-06 26.2 0.0 8.4e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 EDK36563.2 - 0.00017 21.2 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EDK36563.2 - 0.00035 20.1 0.0 0.00059 19.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDK36563.2 - 0.0023 17.5 0.0 0.0039 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EDK36563.2 - 0.0096 15.9 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDK36563.2 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EDK36563.2 - 0.027 13.5 0.0 0.045 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Cnd3 PF12719.7 EDK36564.2 - 7.1e-90 301.2 1.0 7.1e-90 301.2 1.0 3.9 5 0 0 5 5 5 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EDK36564.2 - 3.8e-09 36.8 5.0 0.00011 22.5 0.6 4.5 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.22 EDK36564.2 - 6.1e-05 22.9 2.0 4.2 7.9 0.0 5.8 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EDK36564.2 - 0.0057 16.7 6.3 0.89 9.6 0.0 5.2 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 MIF4G PF02854.19 EDK36564.2 - 0.055 13.1 14.2 0.078 12.6 1.2 3.7 4 0 0 4 4 4 0 MIF4G domain HTH_38 PF13936.6 EDK36564.2 - 0.4 10.5 2.2 0.77 9.6 0.7 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Mak10 PF04112.13 EDK36565.2 - 7.5e-20 71.1 0.2 2.3e-19 69.5 0.2 1.9 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PAP1 PF08601.10 EDK36566.2 - 9.2e-20 71.7 28.4 1.8e-19 70.8 0.1 3.1 2 1 0 2 2 2 1 Transcription factor PAP1 bZIP_1 PF00170.21 EDK36566.2 - 1.9e-11 43.8 7.6 4e-11 42.9 7.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDK36566.2 - 1.4e-05 25.1 11.0 5.1e-05 23.3 10.9 2.0 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDK36566.2 - 0.00079 19.9 7.1 0.0014 19.1 7.1 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor KASH_CCD PF14662.6 EDK36566.2 - 0.0014 18.5 3.5 0.0022 17.8 3.5 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 EDK36566.2 - 0.002 18.0 3.4 0.0031 17.3 3.4 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family SHE3 PF17078.5 EDK36566.2 - 0.0023 17.7 1.9 0.0048 16.7 1.9 1.5 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 RILP PF11461.8 EDK36566.2 - 0.029 14.6 0.0 0.1 12.9 0.0 1.9 1 0 0 1 1 1 0 Rab interacting lysosomal protein dsrm PF00035.26 EDK36566.2 - 0.082 13.6 0.1 0.28 11.9 0.1 1.8 1 0 0 1 1 1 0 Double-stranded RNA binding motif NDUFA12 PF05071.16 EDK36567.1 - 1.1e-27 96.7 4.2 1.6e-27 96.2 4.2 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DS PF01916.17 EDK36568.2 - 7.9e-130 432.3 0.0 9.1e-130 432.1 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF494 PF04361.13 EDK36568.2 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Peptidase_M18 PF02127.15 EDK36569.2 - 1.2e-143 479.1 0.0 1.3e-143 478.9 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDK36569.2 - 0.00095 18.3 0.0 0.035 13.1 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase G-alpha PF00503.20 EDK36571.2 - 4.7e-106 354.9 4.0 6e-106 354.6 4.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EDK36571.2 - 1e-14 54.4 0.7 1.8e-09 37.3 0.2 3.0 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK36571.2 - 0.0053 16.1 0.8 1.1 8.6 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EDK36571.2 - 0.046 14.0 0.2 3.5 7.9 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 EDK36572.2 - 1.7e-72 244.0 0.0 2.3e-72 243.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36572.2 - 5.2e-33 114.4 0.0 1.2e-32 113.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36572.2 - 1.9e-05 24.2 0.0 0.00094 18.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK36572.2 - 0.0091 15.0 0.0 0.24 10.3 0.0 2.3 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDK36572.2 - 0.12 11.7 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SIS PF01380.22 EDK36573.2 - 3.5e-67 224.2 0.1 7.6e-36 122.9 0.1 2.3 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.6 EDK36573.2 - 0.017 15.1 0.0 0.2 11.7 0.0 2.3 2 0 0 2 2 2 0 SIS domain DUF155 PF02582.14 EDK36574.2 - 8.1e-39 133.5 0.0 1.3e-38 132.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Ribosomal_S4Pg PF11993.8 EDK36574.2 - 0.033 14.3 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal S4P (gammaproteobacterial) Candida_ALS_N PF11766.8 EDK36575.2 - 8.5e-68 228.3 0.6 8.5e-68 228.3 0.6 2.5 2 1 0 2 2 2 1 Cell-wall agglutinin N-terminal ligand-sugar binding Ammonium_transp PF00909.21 EDK36576.2 - 3.7e-106 355.2 27.4 4.3e-106 355.0 27.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Aminotran_5 PF00266.19 EDK36577.2 - 1.7e-24 86.5 0.0 2.2e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V SepSecS PF05889.13 EDK36577.2 - 0.0033 16.2 0.0 0.0051 15.6 0.0 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Cys_Met_Meta_PP PF01053.20 EDK36577.2 - 0.0041 15.7 0.1 0.0072 14.9 0.1 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK36577.2 - 0.015 14.5 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK36577.2 - 0.053 12.8 0.1 0.11 11.8 0.1 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TPP_enzyme_N PF02776.18 EDK36578.2 - 1.8e-54 184.0 0.0 3.9e-54 182.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDK36578.2 - 8.3e-49 165.3 1.8 3.4e-47 160.1 0.3 3.7 5 0 0 5 5 5 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDK36578.2 - 3.2e-38 130.5 0.5 6.6e-38 129.5 0.5 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Zn_clus PF00172.18 EDK36579.2 - 5.2e-10 39.3 11.1 8.3e-10 38.6 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MutL_C PF08676.11 EDK36580.2 - 0.042 13.6 0.1 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 MutL C terminal dimerisation domain FliD_C PF07195.12 EDK36580.2 - 0.044 13.2 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus HEAT PF02985.22 EDK36580.2 - 0.07 13.4 1.2 3.6 8.1 0.1 3.9 3 0 0 3 3 3 0 HEAT repeat TAF6_C PF07571.13 EDK36580.2 - 0.76 10.1 3.1 13 6.2 0.2 3.8 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain TetR_C_37 PF18665.1 EDK36580.2 - 0.78 10.4 5.4 3.5 8.3 0.2 3.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Vac14_Fab1_bd PF12755.7 EDK36580.2 - 4 8.1 5.7 1.8 9.2 0.1 3.4 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Ribosomal_L30 PF00327.20 EDK36581.1 - 1.9e-12 46.9 0.8 2.7e-12 46.4 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e MNE1 PF13762.6 EDK36582.2 - 1.2e-46 158.5 9.4 2.2e-45 154.3 8.1 3.2 3 1 0 3 3 3 1 Mitochondrial splicing apparatus component Methyltransf_23 PF13489.6 EDK36583.2 - 8.6e-17 61.5 0.0 1.4e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36583.2 - 6.9e-11 42.8 0.0 1.8e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK36583.2 - 1.5e-09 38.4 0.0 4.4e-09 36.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36583.2 - 7.8e-08 32.3 0.3 3.8e-07 30.0 0.3 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36583.2 - 7.9e-08 32.9 0.0 7.8e-07 29.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain 5_nucleotid PF05761.14 EDK36583.2 - 0.032 13.1 0.1 0.046 12.6 0.1 1.2 1 0 0 1 1 1 0 5' nucleotidase family Ubie_methyltran PF01209.18 EDK36583.2 - 0.091 12.1 0.0 0.58 9.4 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EDK36583.2 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Lon_C PF05362.13 EDK36584.2 - 2.3e-47 161.2 0.1 4e-47 160.4 0.1 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EDK36584.2 - 1.9e-46 158.6 3.0 2.7e-46 158.1 0.1 2.2 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EDK36584.2 - 9.5e-26 90.8 0.0 1.2e-24 87.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK36584.2 - 9.6e-07 28.9 0.0 5.4e-06 26.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EDK36584.2 - 2.2e-06 27.5 0.1 4.4e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 EDK36584.2 - 3.2e-06 27.4 0.0 9.3e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EDK36584.2 - 0.00015 21.8 0.0 0.072 13.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EDK36584.2 - 0.00027 20.7 0.0 0.00087 19.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDK36584.2 - 0.00034 21.0 0.0 0.001 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EDK36584.2 - 0.00036 20.5 2.5 0.039 13.9 0.1 3.4 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_22 PF13401.6 EDK36584.2 - 0.00092 19.5 0.0 0.048 13.9 0.0 3.0 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDK36584.2 - 0.0024 17.7 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EDK36584.2 - 0.0029 16.9 0.1 0.0073 15.6 0.1 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain NB-ARC PF00931.22 EDK36584.2 - 0.0032 16.7 0.0 0.0075 15.5 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Mg_chelatase PF01078.21 EDK36584.2 - 0.0084 15.5 0.0 0.089 12.2 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EDK36584.2 - 0.012 15.8 0.0 0.029 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDK36584.2 - 0.019 14.7 0.5 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDK36584.2 - 0.02 15.4 0.0 0.02 15.4 0.0 2.8 4 0 0 4 4 2 0 AAA domain RsgA_GTPase PF03193.16 EDK36584.2 - 0.028 14.3 0.2 0.093 12.6 0.2 1.9 1 0 0 1 1 1 0 RsgA GTPase PhoH PF02562.16 EDK36584.2 - 0.029 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.17 EDK36584.2 - 0.033 13.9 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EDK36584.2 - 0.034 14.5 1.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 EDK36584.2 - 0.053 12.8 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EDK36584.2 - 0.056 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDK36584.2 - 0.059 12.9 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EDK36584.2 - 0.066 13.1 0.1 0.25 11.2 0.0 2.0 1 1 1 2 2 2 0 NTPase AAA_11 PF13086.6 EDK36584.2 - 0.067 13.0 0.2 0.067 13.0 0.2 2.9 1 1 2 3 3 2 0 AAA domain TsaE PF02367.17 EDK36584.2 - 0.067 13.2 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDK36584.2 - 0.081 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDK36584.2 - 0.081 12.8 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EDK36584.2 - 0.17 11.5 0.1 0.9 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain CENP-Q PF13094.6 EDK36584.2 - 5.2 7.2 10.7 0.17 12.1 1.6 3.1 3 1 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit TRP_N PF14558.6 EDK36585.2 - 1.8e-42 145.0 1.0 1.8e-42 145.0 1.0 1.5 2 0 0 2 2 2 1 ML-like domain TRP PF06011.12 EDK36585.2 - 3.9e-38 131.3 5.6 3.9e-38 131.3 5.6 1.4 2 0 0 2 2 2 1 Transient receptor potential (TRP) ion channel TRP PF06011.12 EDK36586.2 - 3.9e-48 164.2 10.9 4.2e-48 164.1 10.9 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel LapA_dom PF06305.11 EDK36586.2 - 0.0093 15.8 0.6 0.0093 15.8 0.6 1.7 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain zf-LITAF-like PF10601.9 EDK36586.2 - 0.09 13.1 2.3 0.11 12.8 0.3 2.0 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain DUF202 PF02656.15 EDK36586.2 - 0.12 12.9 0.7 0.12 12.9 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF202) RhodobacterPufX PF11511.8 EDK36586.2 - 0.39 10.3 1.9 0.96 9.1 1.9 1.6 1 0 0 1 1 1 0 Intrinsic membrane protein PufX DUF4282 PF14110.6 EDK36586.2 - 9.1 7.1 10.7 12 6.7 3.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) RIBIOP_C PF04950.12 EDK36588.2 - 1.2e-89 300.6 0.0 1.2e-89 300.6 0.0 2.6 3 0 0 3 3 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDK36588.2 - 1.4e-31 108.4 0.8 2.3e-30 104.5 0.0 3.2 3 0 0 3 3 2 1 AARP2CN (NUC121) domain AAA_33 PF13671.6 EDK36588.2 - 1.2e-06 28.7 0.0 1.2e-06 28.7 0.0 2.6 3 0 0 3 3 1 1 AAA domain GTP_EFTU PF00009.27 EDK36588.2 - 2.9e-06 27.0 0.0 0.0026 17.3 0.0 2.8 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDK36588.2 - 1.1e-05 25.9 0.3 4.2e-05 24.0 0.0 2.1 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 EDK36588.2 - 1.2e-05 25.7 0.4 3.3e-05 24.3 0.1 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDK36588.2 - 3.9e-05 23.9 0.1 0.00016 21.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK36588.2 - 0.0014 19.0 0.0 0.0046 17.3 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EDK36588.2 - 0.0019 18.4 0.2 0.01 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EDK36588.2 - 0.0039 17.3 0.3 0.019 15.0 0.3 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EDK36588.2 - 0.0039 17.7 2.1 0.0078 16.7 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_19 PF13245.6 EDK36588.2 - 0.0045 17.3 0.3 0.011 16.1 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDK36588.2 - 0.0055 16.5 0.2 0.0055 16.5 0.2 4.3 3 2 0 3 3 2 1 AAA domain NTPase_1 PF03266.15 EDK36588.2 - 0.0064 16.4 0.9 0.018 14.9 0.9 1.8 1 0 0 1 1 1 1 NTPase PduV-EutP PF10662.9 EDK36588.2 - 0.0073 16.1 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDK36588.2 - 0.0077 16.2 0.1 0.017 15.1 0.1 1.6 1 1 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 EDK36588.2 - 0.0089 15.8 0.2 0.025 14.3 0.2 1.7 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EDK36588.2 - 0.011 15.0 0.5 0.023 13.9 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 EDK36588.2 - 0.012 15.6 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDK36588.2 - 0.013 15.3 0.1 0.1 12.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDK36588.2 - 0.015 14.8 0.1 0.033 13.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EDK36588.2 - 0.023 15.2 0.0 0.023 15.2 0.0 4.1 4 0 0 4 4 3 0 AAA domain MobB PF03205.14 EDK36588.2 - 0.026 14.4 2.9 0.047 13.6 0.3 2.7 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 EDK36588.2 - 0.028 14.0 0.4 0.059 12.9 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 EDK36588.2 - 0.057 13.3 0.6 0.38 10.6 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 EDK36588.2 - 0.091 12.8 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 EDK36588.2 - 0.24 11.1 0.8 0.41 10.4 0.1 1.7 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase Cyclin PF08613.11 EDK36589.2 - 4.3e-20 72.7 2.6 7.2e-20 72.0 2.6 1.4 1 0 0 1 1 1 1 Cyclin MmlI PF09448.10 EDK36590.2 - 0.0017 18.8 0.0 1.3 9.5 0.0 2.7 3 1 0 3 3 3 2 Methylmuconolactone methyl-isomerase Ribonuclease_3 PF00636.26 EDK36590.2 - 0.076 13.6 0.0 0.23 12.1 0.0 1.8 1 1 0 1 1 1 0 Ribonuclease III domain Cytokin_check_N PF10407.9 EDK36591.2 - 3e-27 94.4 0.3 5.7e-27 93.5 0.3 1.5 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus Par3_HAL_N_term PF12053.8 EDK36591.2 - 0.057 13.6 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins tRNA-synt_2b PF00587.25 EDK36592.2 - 1.6e-33 116.2 0.0 3.4e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDK36592.2 - 7.8e-23 80.8 7.6 7.8e-23 80.8 7.6 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF3698 PF12479.8 EDK36592.2 - 0.13 12.8 0.0 0.13 12.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) ATG19_autophagy PF12744.7 EDK36592.2 - 0.34 10.1 7.4 0.43 9.7 6.2 1.7 2 0 0 2 2 2 0 Autophagy protein Atg19, Atg8-binding KIP1 PF07765.12 EDK36592.2 - 0.37 11.0 4.6 4 7.6 2.4 3.0 1 1 2 3 3 3 0 KIP1-like protein NPV_P10 PF05531.12 EDK36592.2 - 3.2 8.3 5.2 2.5 8.6 2.8 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.32 EDK36593.2 - 9.4e-21 73.8 11.7 0.0002 22.1 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36593.2 - 1.2e-07 32.0 0.8 0.6 10.4 0.0 4.9 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK36593.2 - 1.7e-06 27.0 3.1 0.47 9.0 0.0 3.9 2 2 2 4 4 4 3 Nucleoporin Nup120/160 Afi1 PF07792.12 EDK36593.2 - 0.092 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking adh_short_C2 PF13561.6 EDK36594.2 - 1.2e-40 139.5 0.0 1.5e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK36594.2 - 1.8e-32 112.4 0.0 2.1e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK36594.2 - 2.2e-10 40.7 0.0 1.8e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 KR domain NUFIP1 PF10453.9 EDK36595.2 - 2.4e-17 62.5 4.6 7.7e-17 60.9 4.6 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 EDK36595.2 - 2.1e-05 24.3 3.5 3.1e-05 23.7 3.5 1.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK36595.2 - 5.4e-05 23.1 9.2 8.2e-05 22.5 9.2 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDK36595.2 - 0.00011 22.0 4.6 0.00015 21.5 4.6 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EDK36595.2 - 0.027 15.2 0.1 0.046 14.4 0.1 1.5 1 0 0 1 1 1 0 Torus domain ANAPC_CDC26 PF10471.9 EDK36595.2 - 0.089 13.6 1.2 0.17 12.7 0.0 2.1 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 zf-CCCH_2 PF14608.6 EDK36595.2 - 0.9 10.1 5.4 2 9.0 5.4 1.6 1 1 0 1 1 1 0 RNA-binding, Nab2-type zinc finger FA_desaturase PF00487.24 EDK36596.2 - 1.8e-27 96.8 24.4 2.7e-27 96.2 24.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EDK36596.2 - 8.7e-12 45.0 0.0 2e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFIIB PF00382.19 EDK36597.2 - 1.8e-42 143.3 0.6 5.2e-20 71.3 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EDK36597.2 - 6.8e-13 47.9 1.3 1.2e-12 47.1 1.3 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EDK36597.2 - 0.039 13.4 3.5 0.78 9.2 3.5 2.4 1 1 0 1 1 1 0 zinc-ribbon domain mTERF PF02536.14 EDK36597.2 - 0.047 12.6 0.1 0.07 12.0 0.1 1.2 1 0 0 1 1 1 0 mTERF Chordopox_RPO7 PF05864.12 EDK36597.2 - 0.24 11.7 4.1 48 4.3 0.4 3.9 3 1 1 4 4 4 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Mcp5_PH PF12814.7 EDK36598.2 - 7.3e-45 152.0 0.1 3e-44 150.1 0.1 2.2 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology UPF0180 PF03698.13 EDK36598.2 - 0.00014 21.9 0.4 6.3 7.0 0.0 6.4 6 1 0 6 6 6 2 Uncharacterised protein family (UPF0180) PH PF00169.29 EDK36598.2 - 0.0022 18.5 0.0 0.011 16.3 0.0 2.4 1 0 0 1 1 1 1 PH domain HTH_3 PF01381.22 EDK36598.2 - 0.0035 17.4 5.7 20 5.3 0.1 9.2 11 0 0 11 11 11 1 Helix-turn-helix MoCF_biosynth PF00994.24 EDK36598.2 - 0.03 14.0 0.6 11 5.6 0.1 3.4 2 0 0 2 2 2 0 Probable molybdopterin binding domain Flu_NS2 PF00601.19 EDK36598.2 - 0.032 14.5 2.3 2.6 8.4 0.0 4.8 4 0 0 4 4 4 0 Influenza non-structural protein (NS2) Vac14_Fig4_bd PF11916.8 EDK36598.2 - 0.75 9.4 4.6 2.4 7.8 0.1 4.2 5 0 0 5 5 5 0 Vacuolar protein 14 C-terminal Fig4p binding ACCA PF03255.14 EDK36598.2 - 5 7.0 12.2 12 5.7 5.2 4.9 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF3533 PF12051.8 EDK36599.2 - 1.7e-138 461.7 19.4 2e-138 461.5 19.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF4234 PF14018.6 EDK36599.2 - 0.038 14.1 0.4 0.038 14.1 0.4 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4234) PGA2 PF07543.12 EDK36599.2 - 0.11 12.5 0.5 0.25 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 PMT PF02366.18 EDK36600.2 - 1.4e-82 277.0 24.1 1.4e-82 277.0 24.1 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDK36600.2 - 7.7e-54 182.3 15.6 7.7e-54 182.3 15.6 2.6 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDK36600.2 - 1.6e-22 80.2 0.2 3.1e-22 79.3 0.2 1.3 1 0 0 1 1 1 1 MIR domain CBFD_NFYB_HMF PF00808.23 EDK36601.2 - 4e-19 68.7 0.8 4e-19 68.7 0.8 2.3 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK36601.2 - 1.3e-16 61.2 0.6 1.3e-16 61.2 0.6 2.2 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EDK36601.2 - 0.0098 16.2 0.5 0.038 14.3 0.1 2.1 2 0 0 2 2 2 1 CENP-S associating Centromere protein X SPOB_a PF14689.6 EDK36601.2 - 0.054 13.2 0.3 0.12 12.2 0.3 1.6 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain PBP PF01161.20 EDK36602.2 - 1.4e-23 83.7 0.0 1.9e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DIM1 PF02966.16 EDK36604.1 - 4.6e-69 230.3 0.1 5.6e-69 230.1 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Amidohydro_2 PF04909.14 EDK36605.2 - 2.1e-05 24.5 0.0 6.5e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase Sugar_tr PF00083.24 EDK36606.2 - 1.3e-29 103.4 29.9 9.1e-20 70.9 12.0 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EDK36606.2 - 1.7e-14 53.6 43.3 2.7e-08 33.2 27.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HSP20 PF00011.21 EDK36607.2 - 0.00045 20.3 2.9 0.76 10.0 0.1 3.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family Macoilin PF09726.9 EDK36607.2 - 0.00062 18.5 16.2 0.00062 18.5 16.2 3.2 2 1 0 2 2 2 1 Macoilin family SLC12 PF03522.15 EDK36607.2 - 7 5.6 28.4 0.017 14.2 8.5 2.7 2 1 0 2 2 2 0 Solute carrier family 12 AA_permease PF00324.21 EDK36608.2 - 5.6e-78 262.6 51.4 2e-76 257.5 51.4 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK36608.2 - 2.2e-29 102.6 40.2 4.7e-29 101.5 40.2 1.5 1 1 0 1 1 1 1 Amino acid permease DOCK_N PF16172.5 EDK36609.2 - 1.3e-08 34.2 0.0 4.4e-08 32.4 0.0 1.7 1 1 0 1 1 1 1 DOCK N-terminus DOCK_N PF16172.5 EDK36610.1 - 0.00087 18.3 0.0 0.0016 17.4 0.0 1.4 1 1 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EDK36612.2 - 3.8e-50 171.0 0.2 3.6e-49 167.8 0.2 2.0 1 1 0 1 1 1 1 Dock homology region 2 Herpes_capsid PF06112.11 EDK36612.2 - 5.8 6.9 13.8 10 6.1 13.8 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PP-binding PF00550.25 EDK36613.1 - 9.5e-11 41.9 0.6 1.3e-10 41.5 0.6 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EDK36613.1 - 9.6e-06 25.7 0.9 2.1e-05 24.6 0.5 1.7 1 1 1 2 2 2 1 Acyl-carrier LRR_4 PF12799.7 EDK36614.1 - 4.6e-34 115.9 45.7 7.4e-09 35.8 6.7 6.7 7 0 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK36614.1 - 5.4e-18 64.5 42.8 1.4e-05 24.8 3.4 6.1 4 2 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EDK36614.1 - 1.6e-17 63.6 22.2 3.9e-11 42.8 10.8 4.4 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EDK36614.1 - 0.00069 19.8 24.2 3.6 8.5 0.3 8.3 8 2 0 8 8 8 3 Leucine Rich Repeat LRR_6 PF13516.6 EDK36614.1 - 0.00092 19.1 29.5 0.22 11.7 0.3 7.5 7 1 1 8 8 8 4 Leucine Rich repeat UB2H PF14814.6 EDK36614.1 - 0.058 13.4 3.6 16 5.6 0.0 4.5 2 2 4 6 6 6 0 Bifunctional transglycosylase second domain LRR_2 PF07723.13 EDK36614.1 - 0.084 13.6 1.7 40 5.1 0.1 3.9 5 0 0 5 5 5 0 Leucine Rich Repeat IF-2B PF01008.17 EDK36615.2 - 2.6e-40 138.4 2.1 4.8e-40 137.5 2.1 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family CLTH PF10607.9 EDK36615.2 - 0.036 14.0 0.1 0.095 12.6 0.0 1.6 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Med1 PF10744.9 EDK36616.2 - 1.4e-35 123.1 0.1 1.1e-34 120.3 0.1 2.3 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 DUF5643 PF18705.1 EDK36616.2 - 0.27 11.2 1.7 0.49 10.4 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5643) Ubie_methyltran PF01209.18 EDK36617.2 - 1.5e-87 292.8 0.1 1.7e-87 292.6 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDK36617.2 - 6.4e-13 49.2 0.0 1.9e-12 47.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK36617.2 - 1.1e-10 42.0 0.0 2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36617.2 - 2.8e-09 37.0 0.0 5.6e-09 36.0 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36617.2 - 2e-08 34.9 0.0 4.3e-08 33.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK36617.2 - 0.00094 19.0 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EDK36617.2 - 0.15 11.9 0.0 0.62 9.9 0.0 2.0 3 0 0 3 3 3 0 Hypothetical methyltransferase PK PF00224.21 EDK36618.1 - 5.7e-169 561.5 3.3 7.6e-169 561.1 3.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EDK36618.1 - 1.4e-37 128.4 0.2 4.4e-37 126.9 0.2 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EDK36618.1 - 0.00058 19.1 0.2 0.0014 17.8 0.1 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DnaJ PF00226.31 EDK36619.2 - 2.6e-06 27.5 0.4 6.1e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain Pam16 PF03656.13 EDK36619.2 - 0.014 15.4 0.0 0.032 14.3 0.0 1.6 2 0 0 2 2 2 0 Pam16 CDP-OH_P_tran_2 PF08009.11 EDK36619.2 - 0.039 13.8 1.2 0.069 13.1 1.2 1.4 1 0 0 1 1 1 0 CDP-alcohol phosphatidyltransferase 2 NEMO PF11577.8 EDK36619.2 - 0.074 13.1 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO AAA PF00004.29 EDK36620.2 - 1e-56 190.9 0.0 7.6e-43 146.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK36620.2 - 3.4e-08 33.1 0.1 0.0078 16.0 0.0 3.2 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDK36620.2 - 1.3e-05 25.0 0.0 0.0014 18.4 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDK36620.2 - 2.3e-05 24.9 0.1 0.025 15.0 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain Parvo_NS1 PF01057.17 EDK36620.2 - 0.00029 20.0 0.0 0.00057 19.1 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Vps4_C PF09336.10 EDK36620.2 - 0.0017 18.3 0.2 0.011 15.7 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 EDK36620.2 - 0.0019 18.5 0.0 0.02 15.3 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 EDK36620.2 - 0.0022 18.2 0.0 0.0077 16.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDK36620.2 - 0.0043 16.8 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EDK36620.2 - 0.0048 17.2 0.1 0.055 13.8 0.0 2.7 2 1 1 3 3 3 1 AAA domain TsaE PF02367.17 EDK36620.2 - 0.005 16.8 0.0 0.23 11.5 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EDK36620.2 - 0.0089 16.0 0.0 0.066 13.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK36620.2 - 0.0096 16.1 0.0 0.46 10.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EDK36620.2 - 0.01 15.1 0.1 0.027 13.7 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 EDK36620.2 - 0.01 15.4 0.0 0.027 14.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 EDK36620.2 - 0.018 14.4 0.1 0.052 12.9 0.0 1.8 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 EDK36620.2 - 0.02 14.3 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDK36620.2 - 0.028 15.0 0.0 0.15 12.6 0.0 2.4 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.6 EDK36620.2 - 0.033 14.6 0.0 3.7 8.0 0.0 3.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDK36620.2 - 0.05 13.8 0.0 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDK36620.2 - 0.064 12.8 0.0 0.47 10.0 0.0 2.4 1 1 1 2 2 2 0 AAA domain PhoH PF02562.16 EDK36620.2 - 0.12 11.8 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_3 PF07726.11 EDK36620.2 - 0.13 12.1 0.0 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L31e PF01198.19 EDK36621.1 - 7.9e-16 58.1 0.2 1e-15 57.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Chorismate_bind PF00425.18 EDK36623.2 - 0.001 18.7 0.5 0.0014 18.3 0.5 1.2 1 0 0 1 1 1 1 chorismate binding enzyme DUF480 PF04337.12 EDK36623.2 - 0.047 13.8 1.6 0.055 13.6 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF480 DUF4050 PF13259.6 EDK36624.2 - 8e-08 32.8 12.1 2.9e-07 31.0 0.0 3.3 1 1 2 3 3 3 2 Protein of unknown function (DUF4050) Rxt3 PF08642.10 EDK36625.2 - 2.6e-19 70.3 9.9 6e-19 69.1 0.1 4.0 2 2 0 2 2 2 1 Histone deacetylation protein Rxt3 GREB1 PF15782.5 EDK36625.2 - 0.37 7.9 12.4 0.46 7.5 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 EDK36625.2 - 6.9 5.1 18.2 16 3.9 18.2 1.7 1 1 0 1 1 1 0 Macoilin family Vps39_1 PF10366.9 EDK36626.2 - 2.9e-30 104.7 0.4 2.9e-30 104.7 0.4 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EDK36626.2 - 4.1e-17 62.6 0.4 1.5e-16 60.8 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EDK36626.2 - 2.5e-09 37.2 0.4 6e-09 35.9 0.4 1.6 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 EDK36626.2 - 2.1e-07 30.9 6.4 3.8e-05 23.6 3.0 3.7 2 1 1 3 3 3 1 Region in Clathrin and VPS Utp21 PF04192.12 EDK36627.2 - 2.7e-72 243.0 2.0 4.2e-72 242.4 2.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EDK36627.2 - 2.5e-16 59.8 0.0 6.5e-05 23.1 0.0 5.7 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK36627.2 - 2e-12 47.4 10.9 9.1e-07 29.5 0.0 8.3 9 0 0 9 9 9 2 WD domain, G-beta repeat eIF2A PF08662.11 EDK36627.2 - 0.00031 20.7 0.0 0.21 11.5 0.0 2.8 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 EDK36627.2 - 0.0022 17.6 0.0 0.017 14.7 0.0 2.4 2 0 0 2 2 2 1 PQQ-like domain WD40_like PF17005.5 EDK36627.2 - 0.0071 15.7 0.3 0.2 10.9 0.0 2.9 2 1 0 2 2 2 1 WD40-like domain MACPF PF01823.19 EDK36627.2 - 0.012 15.7 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 MAC/Perforin domain Cytochrom_D1 PF02239.16 EDK36627.2 - 0.11 11.0 0.0 0.24 9.9 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain Dus PF01207.17 EDK36628.2 - 1.7e-47 162.1 0.0 2.3e-46 158.3 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EDK36628.2 - 1.6 8.7 4.7 2.1 8.4 0.4 2.3 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Bap31 PF05529.12 EDK36629.1 - 8.7e-47 158.4 0.2 1.1e-46 158.0 0.2 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EDK36629.1 - 3.7e-08 33.2 4.5 6.2e-08 32.5 4.5 1.3 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Clp1 PF06807.14 EDK36629.1 - 0.11 13.0 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 Mem_trans PF03547.18 EDK36630.2 - 5.2e-29 100.8 0.0 6.5e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Membrane transport protein Capsid-VNN PF11729.8 EDK36630.2 - 0.087 11.8 1.3 0.14 11.1 0.5 1.7 2 0 0 2 2 2 0 nodavirus capsid protein DUF3246 PF11596.8 EDK36630.2 - 0.23 10.8 3.3 0.4 10.1 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) SSrecog PF03531.14 EDK36631.2 - 3.5e-31 106.9 0.6 8e-29 99.4 0.1 3.7 4 0 0 4 4 4 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EDK36631.2 - 4.5e-30 103.9 0.0 8.7e-28 96.6 0.0 3.3 4 0 0 4 4 4 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EDK36631.2 - 7.9e-29 99.9 1.0 5.3e-26 90.9 0.0 3.6 4 0 0 4 4 4 2 POB3-like N-terminal PH domain Gin PF10764.9 EDK36631.2 - 0.1 12.6 0.3 0.25 11.3 0.3 1.7 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin bPH_2 PF03703.14 EDK36631.2 - 0.11 12.6 0.0 3.9 7.8 0.0 2.9 3 0 0 3 3 3 0 Bacterial PH domain Semialdhyde_dhC PF02774.18 EDK36632.2 - 3e-40 138.3 0.0 4.5e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EDK36632.2 - 5.4e-34 117.2 0.0 9.6e-34 116.4 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EDK36632.2 - 0.00074 19.8 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DXP_reductoisom PF02670.16 EDK36632.2 - 0.0015 19.3 0.0 0.0036 18.0 0.0 1.7 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 EDK36632.2 - 0.012 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 EDK36632.2 - 0.074 12.9 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding Methyltransf_16 PF10294.9 EDK36633.2 - 2.1e-07 30.9 0.0 9.5e-06 25.5 0.0 2.2 1 1 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 EDK36633.2 - 0.2 11.4 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SAC3_GANP PF03399.16 EDK36634.2 - 5.1e-110 367.5 0.2 8.9e-110 366.7 0.2 1.4 1 0 0 1 1 1 1 SAC3/GANP family SAC3 PF12209.8 EDK36634.2 - 5.7e-24 84.1 1.7 2e-23 82.3 1.7 2.1 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain CSN8_PSD8_EIF3K PF10075.9 EDK36634.2 - 0.0031 17.5 1.9 0.035 14.1 0.2 3.1 2 1 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF4936 PF16290.5 EDK36634.2 - 0.057 14.1 0.0 0.28 11.9 0.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4936) DUF445 PF04286.12 EDK36634.2 - 0.21 11.4 9.8 0.054 13.3 2.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF445) Sybindin PF04099.12 EDK36635.2 - 2.1e-16 60.2 0.2 2.4e-16 59.9 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family ENTH PF01417.20 EDK36636.2 - 1.3e-44 151.2 0.1 2e-44 150.6 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDK36636.2 - 0.00047 19.2 0.0 0.00063 18.8 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 EDK36636.2 - 0.13 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 VHS domain DSS1_SEM1 PF05160.13 EDK36636.2 - 2.1 8.5 6.2 3.5 7.8 0.4 3.0 4 0 0 4 4 4 0 DSS1/SEM1 family DUF3246 PF11596.8 EDK36636.2 - 6.1 6.2 11.4 0.087 12.2 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Pro_isomerase PF00160.21 EDK36637.1 - 3.5e-49 167.1 0.0 4.7e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CCDC84 PF14968.6 EDK36639.2 - 0.0016 18.1 0.6 0.0016 18.1 0.6 1.6 1 1 1 2 2 2 1 Coiled coil protein 84 zf-met PF12874.7 EDK36639.2 - 0.0062 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDK36639.2 - 0.039 14.8 0.1 0.1 13.5 0.0 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger DUF4404 PF14357.6 EDK36639.2 - 0.063 13.9 2.8 0.16 12.6 2.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) zf-C2H2 PF00096.26 EDK36639.2 - 0.063 13.8 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDK36639.2 - 0.071 13.4 0.0 0.18 12.1 0.0 1.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF1168 PF06658.12 EDK36639.2 - 3.4 7.5 21.2 0.22 11.3 11.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) PNK3P PF08645.11 EDK36640.2 - 2.2e-52 177.0 0.6 3.2e-52 176.5 0.6 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase HAD_2 PF13419.6 EDK36640.2 - 0.056 13.5 1.7 21 5.1 0.0 3.3 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK36640.2 - 0.3 10.8 2.0 2.5 7.8 2.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF16 PF01519.16 EDK36641.2 - 0.2 12.2 2.3 1.1 9.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 Ribosomal_S8 PF00410.19 EDK36642.2 - 8.4e-14 51.6 0.0 7.6e-13 48.5 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8 Bestrophin PF01062.21 EDK36643.1 - 0.054 12.9 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF4201 PF13870.6 EDK36644.2 - 0.0004 20.1 0.5 0.0004 20.1 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) TMF_DNA_bd PF12329.8 EDK36644.2 - 0.00071 19.5 2.9 0.00071 19.5 2.9 2.9 3 0 0 3 3 2 1 TATA element modulatory factor 1 DNA binding Pox_A_type_inc PF04508.12 EDK36644.2 - 0.003 17.3 2.0 0.46 10.4 0.1 2.8 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat DivIC PF04977.15 EDK36644.2 - 0.0071 16.1 1.0 0.0071 16.1 1.0 2.6 2 0 0 2 2 2 1 Septum formation initiator SUI1 PF01253.22 EDK36644.2 - 0.022 15.3 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor SUI1 Med9 PF07544.13 EDK36644.2 - 0.034 14.2 1.4 0.034 14.2 1.4 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 CENP-H PF05837.12 EDK36644.2 - 0.11 12.9 0.0 0.11 12.9 0.0 2.8 2 1 1 3 3 2 0 Centromere protein H (CENP-H) SlyX PF04102.12 EDK36644.2 - 0.23 12.1 0.1 0.23 12.1 0.1 2.4 2 0 0 2 2 2 0 SlyX FlaC_arch PF05377.11 EDK36644.2 - 0.49 10.8 5.8 2.5 8.6 0.1 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Herpes_UL6 PF01763.16 EDK36644.2 - 3.6 6.0 8.7 0.12 10.9 0.8 1.9 1 1 0 2 2 2 0 Herpesvirus UL6 like ATG16 PF08614.11 EDK36644.2 - 4.3 7.5 21.2 1.1e+02 2.9 21.2 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EDK36644.2 - 8.7 6.5 11.3 0.14 12.4 2.5 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Zip PF02535.22 EDK36645.2 - 8.7e-78 261.9 1.4 9.9e-78 261.7 1.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter UNC-50 PF05216.13 EDK36645.2 - 1.5e-05 24.7 0.4 0.033 13.8 0.1 2.2 2 0 0 2 2 2 2 UNC-50 family Connexin PF00029.19 EDK36645.2 - 0.02 14.6 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Connexin Syndecan PF01034.20 EDK36645.2 - 0.027 14.4 0.0 0.11 12.4 0.0 2.1 1 0 0 1 1 1 0 Syndecan domain FAM176 PF14851.6 EDK36645.2 - 0.05 13.3 0.1 0.096 12.3 0.1 1.4 1 0 0 1 1 1 0 FAM176 family MAP17 PF15807.5 EDK36645.2 - 0.073 13.3 0.1 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Sporozoite_P67 PF05642.11 EDK36645.2 - 0.13 10.3 1.7 0.19 9.8 1.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CBS PF00571.28 EDK36646.1 - 4.1e-25 88.0 7.1 2.3e-11 44.0 0.3 4.4 4 0 0 4 4 4 4 CBS domain Gly_transf_sug PF04488.15 EDK36646.1 - 0.0053 17.4 0.7 0.037 14.6 0.1 2.6 2 1 1 3 3 3 1 Glycosyltransferase sugar-binding region containing DXD motif OPT PF03169.15 EDK36647.2 - 1.1e-145 486.7 34.2 1.3e-145 486.5 34.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2583 PF10762.9 EDK36647.2 - 1.4 9.4 5.3 2.1 8.8 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2583) Claudin_2 PF13903.6 EDK36647.2 - 7 6.3 13.2 0.3 10.8 3.2 3.4 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction KH_1 PF00013.29 EDK36648.2 - 5.7e-40 135.0 6.0 5e-13 48.7 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDK36648.2 - 1.4e-11 44.1 4.8 0.0036 17.1 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EDK36648.2 - 2.4e-07 30.5 0.9 0.17 11.7 0.0 4.0 4 1 0 4 4 4 3 KH domain KH_5 PF13184.6 EDK36648.2 - 0.0018 18.3 5.3 3.1 8.0 0.3 3.4 3 0 0 3 3 3 3 NusA-like KH domain BCNT PF07572.12 EDK36649.2 - 4.3e-25 87.6 2.4 1.5e-24 85.8 2.5 1.9 2 0 0 2 2 2 1 Bucentaur or craniofacial development Peptidase_M49 PF03571.15 EDK36650.2 - 6.8e-229 760.8 0.0 8.5e-229 760.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 sCache_like PF16736.5 EDK36650.2 - 0.02 15.0 0.2 0.048 13.8 0.2 1.6 1 0 0 1 1 1 0 Single Cache-like DUF3910 PF13049.6 EDK36650.2 - 0.034 14.5 0.1 0.087 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3910) DnaB_2 PF07261.11 EDK36650.2 - 0.11 12.3 0.1 2.4 7.9 0.0 2.8 2 0 0 2 2 2 0 Replication initiation and membrane attachment MogR_DNAbind PF12181.8 EDK36650.2 - 0.18 11.7 1.2 0.58 10.0 0.2 2.1 2 0 0 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) ABC_membrane PF00664.23 EDK36651.2 - 2.3e-48 165.2 6.8 4.2e-48 164.4 6.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDK36651.2 - 9.8e-29 100.6 0.3 6.7e-28 97.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EDK36651.2 - 7.1e-07 28.9 0.0 1.3e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EDK36651.2 - 0.00017 20.5 0.2 0.00028 19.8 0.2 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA PF00004.29 EDK36651.2 - 0.00088 19.7 0.8 0.041 14.3 0.1 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDK36651.2 - 0.0016 18.9 0.1 0.014 15.7 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK36651.2 - 0.0027 18.0 0.0 0.02 15.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain DUF2073 PF09846.9 EDK36651.2 - 0.017 14.9 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2073) CBP_BcsR PF10945.8 EDK36651.2 - 0.047 13.2 0.2 0.14 11.7 0.2 1.8 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsR AAA_25 PF13481.6 EDK36651.2 - 0.062 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EDK36651.2 - 0.21 11.6 4.6 1.4 9.0 0.1 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain DNA_pol_phi PF04931.13 EDK36652.1 - 3.1e-18 65.3 7.7 3.1e-18 65.3 7.7 2.1 2 0 0 2 2 2 2 DNA polymerase phi DNA_pol_phi PF04931.13 EDK36653.2 - 2.8e-145 485.4 20.8 3.5e-145 485.1 20.8 1.0 1 0 0 1 1 1 1 DNA polymerase phi DUF4070 PF13282.6 EDK36653.2 - 0.013 15.6 0.1 0.055 13.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4070) PfkB PF00294.24 EDK36654.1 - 1.6e-69 234.5 0.6 1.8e-69 234.4 0.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDK36654.1 - 0.0013 18.1 0.1 0.0052 16.2 0.0 1.9 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase TRAM_LAG1_CLN8 PF03798.16 EDK36655.1 - 6.2e-41 140.3 15.6 1e-40 139.6 15.6 1.3 1 0 0 1 1 1 1 TLC domain Ras PF00071.22 EDK36656.1 - 2.1e-64 216.0 0.2 2.5e-64 215.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK36656.1 - 1.1e-36 125.7 0.1 1.8e-36 125.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK36656.1 - 7.7e-17 61.3 0.1 9.9e-17 60.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK36656.1 - 2.5e-06 27.0 0.0 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDK36656.1 - 5.4e-05 23.1 0.3 0.16 11.9 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDK36656.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK36656.1 - 0.00022 20.8 0.1 0.00072 19.1 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDK36656.1 - 0.00074 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 EDK36656.1 - 0.0016 18.8 0.0 0.024 15.0 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDK36656.1 - 0.011 16.2 0.0 0.017 15.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EDK36656.1 - 0.034 13.9 0.1 1.5 8.6 0.0 2.3 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EDK36656.1 - 0.045 13.5 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EDK36656.1 - 0.064 13.5 0.0 0.14 12.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EDK36656.1 - 0.085 12.1 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Septin CENP-M PF11111.8 EDK36656.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) TniB PF05621.11 EDK36656.1 - 0.13 11.6 0.0 0.35 10.3 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 EDK36656.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDK36656.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF3237 PF11578.8 EDK36657.1 - 8.3e-23 80.9 0.0 9.7e-23 80.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Rpn3_C PF08375.11 EDK36658.2 - 7.9e-24 83.9 0.6 7.9e-24 83.9 0.6 1.8 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EDK36658.2 - 5.5e-23 81.5 0.6 2.4e-22 79.4 0.5 2.2 2 0 0 2 2 2 1 PCI domain Il2rg PF15874.5 EDK36658.2 - 0.082 13.2 0.1 0.29 11.4 0.1 1.9 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain Med17 PF10156.9 EDK36659.2 - 7.4e-112 374.4 6.3 8.8e-112 374.2 6.3 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex DUF3181 PF11378.8 EDK36659.2 - 0.11 12.8 0.0 0.34 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) Ilm1 PF10311.9 EDK36660.1 - 8.7e-13 48.2 9.6 8.5e-10 38.5 1.1 2.0 1 1 1 2 2 2 2 Increased loss of mitochondrial DNA protein 1 ABC_membrane_3 PF13748.6 EDK36660.1 - 1.3 8.2 6.4 0.11 11.7 0.5 2.1 2 1 1 3 3 3 0 ABC transporter transmembrane region Cu-oxidase_3 PF07732.15 EDK36661.2 - 8.2e-34 116.2 3.0 9.7e-33 112.7 0.1 3.3 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDK36661.2 - 5.9e-30 103.8 9.0 1.2e-26 93.1 5.5 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EDK36661.2 - 1e-15 58.2 0.0 2e-14 54.0 0.0 2.9 3 1 0 3 3 3 1 Multicopper oxidase DUF1281_C PF18406.1 EDK36661.2 - 0.015 14.9 0.0 1.6 8.5 0.0 2.6 2 0 0 2 2 2 0 Ferredoxin-like domain in Api92-like protein Zip PF02535.22 EDK36662.2 - 1.3e-57 195.5 0.3 1.6e-57 195.3 0.3 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Ribophorin_II PF05817.14 EDK36663.2 - 2.9e-11 42.7 3.5 1.6e-10 40.3 3.5 1.8 1 1 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_S24 PF00717.23 EDK36664.1 - 2e-07 30.9 0.0 8e-07 28.9 0.0 2.0 3 0 0 3 3 3 1 Peptidase S24-like Peptidase_S26 PF10502.9 EDK36664.1 - 0.0025 17.6 0.0 0.0054 16.5 0.0 1.6 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 CBFD_NFYB_HMF PF00808.23 EDK36666.1 - 1.7e-08 34.6 0.0 4.3e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK36666.1 - 7.5e-05 23.1 0.1 0.00012 22.4 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pox_Ag35 PF03286.14 EDK36666.1 - 0.11 12.2 4.6 0.039 13.8 1.1 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MRP-L27 PF09809.9 EDK36667.1 - 9.8e-28 96.3 0.1 2e-27 95.2 0.1 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 Mac_assoc PF16628.5 EDK36667.1 - 0.016 15.5 0.1 0.022 15.0 0.1 1.2 1 0 0 1 1 1 0 Unstructured region on maltose acetyltransferase DAO PF01266.24 EDK36668.2 - 2.7e-29 102.9 0.0 3e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EDK36668.2 - 0.013 14.7 0.2 0.026 13.8 0.2 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EDK36668.2 - 0.015 14.6 0.0 0.042 13.1 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDK36668.2 - 0.036 13.1 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EDK36668.2 - 0.2 10.6 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Glyco_hydro81C PF17652.1 EDK36669.2 - 1.2e-154 514.8 11.0 1.2e-154 514.8 11.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDK36669.2 - 7.8e-101 337.4 10.2 7.8e-101 337.4 10.2 2.0 3 0 0 3 3 3 1 Glycosyl hydrolase family 81 N-terminal domain GRASP55_65 PF04495.14 EDK36670.2 - 9.5e-47 158.8 0.0 6e-43 146.5 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PfkB PF00294.24 EDK36671.2 - 3e-16 59.6 0.0 4e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDK36671.2 - 0.00033 20.1 0.0 0.0005 19.5 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase MFS_1 PF07690.16 EDK36672.2 - 3.2e-32 111.8 30.9 3.2e-32 111.8 30.9 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK36672.2 - 5.2e-09 35.5 16.6 5.2e-09 35.5 16.6 3.7 3 1 0 3 3 3 2 Sugar (and other) transporter DUF2776 PF10951.8 EDK36672.2 - 0.076 12.3 5.6 0.27 10.5 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2776) Peptidase_M48_N PF16491.5 EDK36672.2 - 8.6 6.2 15.0 2.3 8.1 1.1 3.7 3 1 0 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices Ank_2 PF12796.7 EDK36673.2 - 3e-12 47.0 3.4 5.9e-05 23.6 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EDK36673.2 - 3.1e-12 46.4 5.1 1.2e-05 25.5 0.3 3.5 2 1 1 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDK36673.2 - 2e-11 44.1 2.2 0.00012 22.6 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK36673.2 - 6.6e-11 41.4 0.7 0.002 18.5 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EDK36673.2 - 4.5e-09 36.4 4.8 9e-05 22.7 0.2 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) KilA-N PF04383.13 EDK36673.2 - 3.3e-08 33.4 0.1 5.1e-07 29.5 0.1 2.9 1 1 0 1 1 1 1 KilA-N domain UQ_con PF00179.26 EDK36675.1 - 2.4e-38 131.0 0.0 3.3e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rho_GDI PF02115.17 EDK36676.2 - 2.6e-15 56.7 0.0 3.2e-15 56.4 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor RPN7 PF10602.9 EDK36677.2 - 5.2e-59 198.9 3.5 5.2e-59 198.9 3.5 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EDK36677.2 - 2.9e-13 50.3 0.3 7.4e-13 48.9 0.1 1.9 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 EDK36677.2 - 0.043 13.9 0.0 0.24 11.5 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDK36677.2 - 0.047 14.0 0.9 3.3 8.1 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HSCB_C PF07743.13 EDK36677.2 - 0.064 13.8 2.0 0.16 12.5 2.0 1.7 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain TPR_8 PF13181.6 EDK36677.2 - 0.2 11.9 0.2 0.2 11.9 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Acyl-CoA_dh_1 PF00441.24 EDK36678.2 - 3.4e-24 85.8 0.8 5.4e-24 85.1 0.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDK36678.2 - 2.1e-13 50.3 0.0 2.8e-12 46.7 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EDK36678.2 - 2.3e-12 47.6 0.0 4.2e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDK36678.2 - 7e-07 29.6 0.7 1.1e-06 29.0 0.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain LSM PF01423.22 EDK36679.2 - 8.2e-16 57.5 0.1 1.2e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDK36679.2 - 0.049 13.8 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain GCD14 PF08704.10 EDK36680.1 - 1.6e-80 270.3 0.0 2.2e-80 269.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EDK36680.1 - 5e-05 23.1 0.0 8.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EDK36680.1 - 0.0042 16.4 0.0 0.57 9.5 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDK36680.1 - 0.0063 16.3 0.0 0.01 15.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 EDK36680.1 - 0.021 14.7 0.3 0.1 12.4 0.0 2.2 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit N-term Actin PF00022.19 EDK36681.2 - 3.2e-101 338.9 0.0 1.9e-100 336.3 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDK36681.2 - 0.0028 16.5 0.0 0.013 14.4 0.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Actin_micro PF17003.5 EDK36681.2 - 0.13 11.4 0.8 1.1 8.4 0.2 2.1 2 0 0 2 2 2 0 Putative actin-like family Pkinase PF00069.25 EDK36682.2 - 2e-50 171.6 0.0 3.9e-50 170.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36682.2 - 1.1e-19 70.7 0.0 4.4e-19 68.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EDK36682.2 - 0.037 13.7 2.8 3.4 7.2 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EDK36682.2 - 0.077 11.8 0.0 0.077 11.8 0.0 2.6 2 1 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EDK36682.2 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK36682.2 - 0.11 11.8 0.0 0.31 10.3 0.0 1.7 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 EDK36682.2 - 0.14 11.7 0.1 0.14 11.7 0.1 1.9 2 0 0 2 2 2 0 RIO1 family RTA1 PF04479.13 EDK36683.1 - 1.1e-65 221.1 14.2 1.1e-65 221.1 14.2 1.6 1 1 1 2 2 2 1 RTA1 like protein Glu-tRNAGln PF02686.15 EDK36684.2 - 4e-06 27.0 0.7 2.2e-05 24.6 0.0 2.5 3 0 0 3 3 3 1 Glu-tRNAGln amidotransferase C subunit DUF2040 PF09745.9 EDK36685.2 - 0.02 14.9 12.8 0.055 13.5 12.2 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 55 (DUF2040) RsbU_N PF08673.10 EDK36685.2 - 0.037 14.1 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain DUF4548 PF15081.6 EDK36685.2 - 0.055 13.3 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Cep57_CLD PF14073.6 EDK36685.2 - 0.17 11.9 12.4 2.8 7.9 4.7 2.4 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 Mit_KHE1 PF10173.9 EDK36685.2 - 0.72 9.9 8.1 1.8 8.6 8.2 1.7 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Band_7 PF01145.25 EDK36686.2 - 8.9e-32 110.5 1.7 1.3e-31 110.0 1.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EDK36686.2 - 0.0017 18.1 0.2 0.0025 17.6 0.2 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family CDP-OH_P_transf PF01066.21 EDK36687.2 - 9.5e-17 61.5 0.1 2e-16 60.5 0.1 1.6 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Spore_YabQ PF09578.10 EDK36687.2 - 2.4 8.5 8.1 2.3 8.5 3.6 2.2 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) Tom22 PF04281.13 EDK36689.1 - 1e-46 158.2 2.0 1.2e-46 157.9 2.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF3402 PF11882.8 EDK36690.2 - 7e-73 246.3 10.4 2.5e-42 145.6 0.7 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 EDK36690.2 - 1.5e-29 103.1 4.4 5.4e-29 101.3 4.4 2.0 1 0 0 1 1 1 1 N1221-like protein PriA_CRR PF18319.1 EDK36690.2 - 0.16 12.0 0.3 0.33 11.0 0.3 1.5 1 0 0 1 1 1 0 PriA DNA helicase Cys-rich region (CRR) domain Myosin_tail_1 PF01576.19 EDK36690.2 - 0.29 8.9 4.4 0.4 8.4 4.4 1.2 1 0 0 1 1 1 0 Myosin tail AD PF09793.9 EDK36691.2 - 7.4e-08 32.4 0.0 1.4e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain TonB_2 PF13103.6 EDK36691.2 - 0.11 12.8 2.7 4.1 7.7 0.1 3.3 3 1 0 3 3 3 0 TonB C terminal DSPc PF00782.20 EDK36692.2 - 1.5e-06 28.0 0.0 2.7e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDK36692.2 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDK36692.2 - 0.033 14.3 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EDK36692.2 - 0.053 13.5 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family TPR_2 PF07719.17 EDK36693.1 - 4.3e-24 82.6 21.3 5e-08 32.5 0.0 10.5 8 2 2 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDK36693.1 - 1.3e-23 81.7 17.6 2.2e-08 33.5 0.1 9.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK36693.1 - 1.1e-16 59.6 22.8 2e-06 27.5 0.0 9.6 11 0 0 11 11 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36693.1 - 2.8e-16 59.8 10.6 2.4e-05 24.8 0.1 5.6 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDK36693.1 - 1.6e-14 53.1 5.5 0.00036 20.7 0.0 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDK36693.1 - 6.5e-14 51.3 15.6 6.1e-06 25.8 0.0 6.8 5 3 3 8 8 8 3 TPR repeat TPR_12 PF13424.6 EDK36693.1 - 2.2e-12 47.1 12.0 0.0063 16.8 0.0 6.9 6 2 2 8 8 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK36693.1 - 2.1e-09 37.4 9.0 8.3e-05 22.7 0.3 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EDK36693.1 - 1.8e-08 34.9 12.5 0.036 14.7 0.1 6.5 3 2 5 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDK36693.1 - 1.2e-07 32.0 11.9 0.034 15.0 0.1 7.2 5 3 5 10 10 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDK36693.1 - 5e-07 29.8 2.6 0.021 15.0 0.0 5.2 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK36693.1 - 2.9e-05 23.6 0.6 0.075 12.4 0.3 2.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 EDK36693.1 - 0.00023 21.0 6.3 1.3 9.2 0.0 6.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 EDK36693.1 - 0.00043 20.0 13.0 0.52 10.0 0.4 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.10 EDK36693.1 - 0.0014 18.2 1.0 0.0083 15.8 0.2 2.5 3 0 0 3 3 2 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_20 PF14561.6 EDK36693.1 - 0.0034 17.7 8.5 0.91 9.9 0.0 4.6 4 2 1 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK36693.1 - 0.0043 17.6 0.1 0.0043 17.6 0.1 5.6 9 0 0 9 9 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK36693.1 - 0.02 14.1 9.8 0.84 8.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3804 PF12707.7 EDK36693.1 - 0.13 12.0 0.1 0.37 10.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) RRP14 PF15459.6 EDK36693.1 - 0.41 11.3 11.2 0.16 12.6 3.5 3.3 3 0 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 Exonuc_VII_S PF02609.16 EDK36693.1 - 0.66 10.1 6.1 1.1 9.3 0.2 3.9 4 0 0 4 4 3 0 Exonuclease VII small subunit CWC25 PF12542.8 EDK36693.1 - 6.9 7.6 10.7 0.64 11.0 1.6 3.2 3 0 0 3 3 3 0 Pre-mRNA splicing factor Arrestin_N PF00339.29 EDK36694.2 - 8.1e-13 48.7 0.3 3.8e-08 33.5 0.1 3.3 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 EDK36694.2 - 0.016 14.4 0.4 9.6 5.3 0.0 3.2 3 1 0 3 3 3 0 Rgp1 Vps26 PF03643.15 EDK36694.2 - 0.026 13.5 0.0 0.66 8.9 0.0 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 26 NLE PF08154.12 EDK36694.2 - 0.12 12.9 0.1 0.47 11.0 0.1 2.0 1 0 0 1 1 1 0 NLE (NUC135) domain FKBP_C PF00254.28 EDK36695.1 - 1.7e-31 108.4 0.0 2.3e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FeS_assembly_P PF01883.19 EDK36696.2 - 5.1e-11 42.6 0.1 7.6e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Foie-gras_1 PF11817.8 EDK36697.2 - 1.1e-14 54.7 0.1 5.8e-13 49.0 0.0 2.3 1 1 1 2 2 2 2 Foie gras liver health family 1 Gryzun PF07919.12 EDK36697.2 - 3e-08 32.9 1.3 1.8e-07 30.3 0.4 2.2 2 0 0 2 2 2 1 Gryzun, putative trafficking through Golgi Macoilin PF09726.9 EDK36698.2 - 0.25 9.8 11.2 0.48 8.9 11.2 1.4 1 0 0 1 1 1 0 Macoilin family NT-C2 PF10358.9 EDK36699.2 - 7.9e-49 165.1 1.9 1.6e-48 164.2 1.9 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins LSM PF01423.22 EDK36700.1 - 0.0015 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 LSM domain RAM PF15320.6 EDK36700.1 - 3.1 8.5 14.7 4 8.1 14.7 1.2 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Glycogen_syn PF05693.13 EDK36701.1 - 0 1129.7 0.0 0 1129.5 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EDK36701.1 - 1.5e-06 27.9 0.0 8.9e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDK36701.1 - 3.3e-06 27.6 0.0 0.0047 17.4 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDK36701.1 - 4.3e-06 27.3 0.1 8.4e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EDK36701.1 - 1.4e-05 25.1 0.4 2.7e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 EDK36701.1 - 2.1e-05 24.3 0.1 4.7e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain WD40 PF00400.32 EDK36702.2 - 6.6e-41 137.5 21.4 5.1e-08 33.4 0.1 12.9 14 0 0 14 14 14 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36702.2 - 1.5e-28 98.9 0.1 0.00094 19.4 0.0 9.4 4 2 3 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EDK36702.2 - 2.1e-24 85.9 0.1 3.4e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EDK36702.2 - 3.9e-06 26.1 2.2 0.48 9.3 0.0 5.9 5 3 3 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 EDK36702.2 - 2.2e-05 24.4 0.0 9.4e-05 22.3 0.0 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat Utp8 PF10395.9 EDK36702.2 - 0.0071 14.9 0.1 2.1 6.8 0.0 2.6 2 1 1 3 3 3 2 Utp8 family WD40_like PF17005.5 EDK36702.2 - 0.015 14.6 8.0 8.8 5.5 0.0 5.2 5 1 0 6 6 6 0 WD40-like domain RAB3GAP2_N PF14655.6 EDK36702.2 - 0.017 14.4 0.0 0.14 11.4 0.0 2.6 4 0 0 4 4 4 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.16 EDK36702.2 - 0.55 8.7 3.2 2.9 6.3 0.0 3.6 5 0 0 5 5 5 0 Cytochrome D1 heme domain PD40 PF07676.12 EDK36702.2 - 1 9.4 2.8 2.2e+02 1.9 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat MPP6 PF10175.9 EDK36703.2 - 5.8e-14 52.7 7.8 7.7e-14 52.3 7.8 1.2 1 0 0 1 1 1 1 M-phase phosphoprotein 6 CDC45 PF02724.14 EDK36703.2 - 1.5 7.0 7.4 1.4 7.2 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein UPF0029 PF01205.19 EDK36704.1 - 6.8e-33 113.1 0.0 1.1e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EDK36704.1 - 6.9e-10 39.2 0.7 2.7e-09 37.3 0.1 2.2 1 1 1 2 2 2 1 RWD domain Glucan_synthase PF02364.15 EDK36705.2 - 0 1201.8 0.1 0 1201.1 0.1 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDK36705.2 - 8.2e-30 103.8 7.1 1.4e-28 99.8 7.1 2.6 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF4750 PF15938.5 EDK36705.2 - 0.097 12.3 2.1 0.49 10.1 2.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) Peptidase_S8 PF00082.22 EDK36706.2 - 2.8e-28 99.1 9.4 6.4e-28 97.9 9.4 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDK36706.2 - 0.0084 16.8 0.0 0.019 15.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 ACC_central PF08326.12 EDK36707.2 - 1.8e-265 882.8 0.3 2.3e-265 882.4 0.3 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EDK36707.2 - 2.8e-183 610.1 0.0 4e-183 609.6 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EDK36707.2 - 4.5e-51 173.4 0.0 9.1e-51 172.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDK36707.2 - 5.1e-28 97.8 0.1 1.1e-27 96.8 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDK36707.2 - 1.4e-21 76.6 0.0 1.4e-20 73.4 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EDK36707.2 - 7.9e-19 67.3 1.4 1.6e-18 66.3 0.3 2.2 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDK36707.2 - 0.00011 22.0 0.3 0.17 11.7 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EDK36707.2 - 0.015 15.4 0.0 0.064 13.3 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDK36707.2 - 0.036 13.6 0.0 0.094 12.2 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus GxGYxYP_N PF16216.5 EDK36707.2 - 0.037 14.2 0.1 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 GxGYxY sequence motif in domain of unknown function N-terminal ATPgrasp_Ter PF15632.6 EDK36707.2 - 0.057 13.2 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon RnfC_N PF13375.6 EDK36707.2 - 0.11 12.5 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Sugar_tr PF00083.24 EDK36708.2 - 4.8e-103 345.4 13.2 8e-103 344.7 13.2 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK36708.2 - 1e-22 80.6 31.5 8.3e-20 71.0 6.5 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_4 PF06779.14 EDK36708.2 - 0.00065 19.1 0.5 0.00065 19.1 0.5 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF5357 PF17310.2 EDK36708.2 - 0.077 11.5 0.0 0.16 10.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5357) OATP PF03137.20 EDK36708.2 - 1.5 7.0 7.3 0.46 8.7 2.8 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family IL2RB_N1 PF18707.1 EDK36709.1 - 0.0077 16.7 0.4 1.5 9.4 0.1 2.2 2 0 0 2 2 2 2 Interleukin-2 receptor subunit beta N-terminal domain 1 Tim17 PF02466.19 EDK36710.1 - 1.8e-26 92.6 0.9 2.6e-26 92.2 0.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Dus PF01207.17 EDK36711.2 - 4.3e-47 160.7 0.0 1.3e-46 159.1 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) COX5A PF02284.16 EDK36711.2 - 0.069 13.2 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va SWIRM PF04433.17 EDK36712.2 - 2.3e-11 43.9 0.0 6.1e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Mis12 PF05859.12 EDK36714.2 - 9.9e-44 148.7 0.4 1.8e-43 147.9 0.4 1.4 1 0 0 1 1 1 1 Mis12 protein MYCBPAP PF14646.6 EDK36715.2 - 0.068 12.1 0.1 0.068 12.1 0.1 1.7 2 0 0 2 2 2 0 MYCBP-associated protein family RPA43_OB PF17875.1 EDK36716.1 - 3e-23 82.8 0.2 3.3e-22 79.4 0.2 2.4 1 1 0 1 1 1 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EDK36716.1 - 1.6e-15 57.2 0.0 7.2e-15 55.1 0.0 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CorA PF01544.18 EDK36717.2 - 2.5e-06 27.0 9.5 9.4e-06 25.2 9.5 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein vATP-synt_E PF01991.18 EDK36718.1 - 1.2e-60 204.4 20.9 1.4e-60 204.2 20.9 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4162 PF13732.6 EDK36718.1 - 0.65 10.8 6.8 0.26 12.0 1.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4162) DUF2250 PF10007.9 EDK36718.1 - 0.65 10.2 6.4 0.16 12.1 1.8 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) zf-ZPR1 PF03367.13 EDK36718.1 - 5.1 6.9 7.8 4.2 7.2 5.6 2.0 1 1 0 1 1 1 0 ZPR1 zinc-finger domain Mito_carr PF00153.27 EDK36719.1 - 5.7e-52 173.6 3.9 2.5e-18 65.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein GCP_N_terminal PF17681.1 EDK36720.2 - 2.5e-33 116.0 4.4 4.7e-33 115.1 4.4 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDK36720.2 - 1.5e-32 113.3 2.2 3.4e-31 108.9 0.2 2.8 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal DUF2935 PF11155.8 EDK36720.2 - 0.012 15.9 0.2 2.3 8.5 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DUF3546 PF12066.8 EDK36720.2 - 0.25 11.6 0.8 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3546) Aminotran_1_2 PF00155.21 EDK36721.2 - 3.2e-75 253.6 0.0 4.3e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDK36721.2 - 2.4e-06 26.3 0.0 3.9e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDK36721.2 - 1.8e-05 23.9 0.0 0.00024 20.2 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDK36721.2 - 0.00046 19.6 0.3 0.0017 17.7 0.3 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Preseq_ALAS PF09029.10 EDK36721.2 - 0.00058 20.3 0.2 0.0012 19.3 0.2 1.6 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Beta_elim_lyase PF01212.21 EDK36721.2 - 0.0026 17.1 0.0 0.0052 16.1 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase MFS_1 PF07690.16 EDK36722.1 - 1.2e-20 73.8 19.5 1.2e-20 73.8 19.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nucleopor_Nup85 PF07575.13 EDK36722.1 - 0.071 11.7 0.3 0.27 9.8 0.3 1.7 2 0 0 2 2 2 0 Nup85 Nucleoporin BATS PF06968.13 EDK36723.2 - 2.8e-23 81.9 0.1 7e-23 80.6 0.1 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EDK36723.2 - 2.1e-13 51.0 0.1 8.4e-13 49.0 0.0 2.0 3 0 0 3 3 3 1 Radical SAM superfamily INPP5B_PH PF16776.5 EDK36723.2 - 0.015 15.0 0.0 0.043 13.5 0.0 1.7 1 1 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain IMD PF08397.11 EDK36724.2 - 2.1e-07 30.5 4.1 3.2e-07 29.9 4.1 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain Arfaptin PF06456.13 EDK36724.2 - 0.04 13.5 0.1 0.04 13.5 0.1 2.2 1 1 1 2 2 2 0 Arfaptin-like domain POX PF07526.11 EDK36724.2 - 0.058 14.0 1.9 0.17 12.4 1.9 1.7 1 0 0 1 1 1 0 Associated with HOX Amidase PF01425.21 EDK36725.1 - 2.8e-104 349.6 0.0 7e-104 348.3 0.0 1.6 1 1 0 1 1 1 1 Amidase DUF3439 PF11921.8 EDK36725.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSF PF00474.17 EDK36726.2 - 7.4e-09 35.0 16.2 7.4e-09 35.0 16.2 1.8 2 0 0 2 2 2 1 Sodium:solute symporter family 7tm_7 PF08395.12 EDK36726.2 - 0.026 13.8 0.2 0.026 13.8 0.2 1.8 2 0 0 2 2 2 0 7tm Chemosensory receptor DUF1461 PF07314.11 EDK36726.2 - 0.083 12.8 0.5 0.31 10.9 0.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Fungal_trans PF04082.18 EDK36727.2 - 2.3e-18 66.2 0.2 3.9e-18 65.4 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Herpes_env PF01673.18 EDK36727.2 - 0.069 12.1 0.0 0.096 11.6 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Ribonuclease_3 PF00636.26 EDK36728.2 - 5.6e-21 75.1 0.0 4e-20 72.4 0.0 2.3 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDK36728.2 - 1.1e-16 61.2 0.9 1.6e-16 60.6 0.1 1.7 2 0 0 2 2 2 1 Ribonuclease-III-like dsrm PF00035.26 EDK36728.2 - 2.4e-14 53.8 0.0 7.7e-08 32.9 0.0 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif Ribosomal_L10 PF00466.20 EDK36729.2 - 0.00011 22.3 0.0 0.00024 21.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Methyltransf_4 PF02390.17 EDK36730.2 - 3.8e-60 202.3 0.1 4.8e-60 202.0 0.1 1.1 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EDK36730.2 - 4.3e-06 26.4 0.0 5.7e-05 22.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDK36730.2 - 0.00029 21.5 0.0 0.001 19.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36730.2 - 0.0017 18.2 0.1 0.0024 17.7 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDK36730.2 - 0.003 16.9 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 EDK36730.2 - 0.003 17.6 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK36730.2 - 0.017 15.8 0.0 0.67 10.6 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36730.2 - 0.053 14.3 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EDK36730.2 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF844 PF05815.11 EDK36730.2 - 0.14 11.3 0.0 0.41 9.8 0.0 1.6 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF844) Reticulon PF02453.17 EDK36731.2 - 2.9e-22 79.3 0.8 3.9e-22 78.9 0.8 1.1 1 0 0 1 1 1 1 Reticulon DUF4790 PF16037.5 EDK36731.2 - 0.12 12.9 0.2 14 6.2 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4790) VPS11_C PF12451.8 EDK36732.2 - 2.9e-14 53.0 0.7 7.6e-14 51.7 0.7 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EDK36732.2 - 1.7e-08 34.4 5.9 1.7e-08 34.4 5.9 2.7 3 0 0 3 3 3 1 Zinc-finger Clathrin PF00637.20 EDK36732.2 - 6.6e-06 26.1 4.4 6.6e-06 26.1 4.4 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_5 PF14634.6 EDK36732.2 - 0.00036 20.4 8.0 0.00096 19.1 8.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDK36732.2 - 0.0011 19.0 3.9 0.0018 18.3 1.0 2.6 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDK36732.2 - 0.0038 17.5 6.9 0.0038 17.5 6.9 2.1 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EDK36732.2 - 0.023 14.8 2.9 0.055 13.5 2.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDK36732.2 - 0.11 12.3 14.4 0.097 12.5 11.5 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 EDK36732.2 - 0.15 11.9 6.1 0.36 10.6 6.1 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.7 EDK36732.2 - 0.19 12.0 9.2 0.063 13.6 5.8 2.0 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-HC5HC2H_2 PF13832.6 EDK36732.2 - 0.22 11.7 3.6 0.63 10.2 3.6 1.8 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDK36732.2 - 0.71 10.2 9.0 0.14 12.4 5.1 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-Nse PF11789.8 EDK36732.2 - 1.3 8.9 7.7 1.4 8.8 4.6 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Troponin PF00992.20 EDK36734.2 - 0.0051 17.1 2.0 0.008 16.5 2.0 1.3 1 0 0 1 1 1 1 Troponin Acetyltransf_1 PF00583.25 EDK36735.2 - 3.6e-14 53.0 0.0 4.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK36735.2 - 5.6e-08 32.8 0.0 6.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK36735.2 - 1.6e-07 31.7 0.0 2.1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDK36735.2 - 0.008 16.3 0.0 0.012 15.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain EMC1_C PF07774.13 EDK36736.2 - 8.7e-56 189.0 3.1 1.6e-55 188.1 3.1 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal YxiJ PF14176.6 EDK36736.2 - 0.0081 16.6 0.1 0.024 15.1 0.1 1.8 1 0 0 1 1 1 1 YxiJ-like protein PQQ_2 PF13360.6 EDK36736.2 - 0.022 14.4 0.1 0.3 10.6 0.0 2.5 2 1 0 2 2 2 0 PQQ-like domain ANAPC4_WD40 PF12894.7 EDK36736.2 - 0.064 13.6 0.1 2.6 8.4 0.1 3.3 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 EDK36737.2 - 1.9e-07 31.0 9.8 3.4e-07 30.3 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rpr2 PF04032.16 EDK36738.2 - 3.2e-11 43.4 1.6 4.2e-11 43.0 0.1 1.8 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_3 PF13878.6 EDK36738.2 - 0.061 13.2 0.3 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO DUF4674 PF15719.5 EDK36738.2 - 0.38 10.8 8.7 0.2 11.7 7.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4674) zf-C2H2_11 PF16622.5 EDK36738.2 - 0.88 9.4 4.9 2.8 7.8 0.4 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type Pex24p PF06398.11 EDK36739.2 - 3.2e-62 210.7 8.6 4.4e-62 210.2 8.6 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin CENP-B_dimeris PF09026.10 EDK36739.2 - 3.6 8.0 7.9 24 5.4 6.0 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SIR2 PF02146.17 EDK36740.2 - 2.3e-35 122.1 0.0 5.3e-34 117.7 0.0 2.3 1 1 0 1 1 1 1 Sir2 family Pkinase PF00069.25 EDK36741.2 - 6e-76 255.3 0.0 8.2e-76 254.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 EDK36741.2 - 6e-56 188.0 0.0 1.2e-55 187.0 0.0 1.5 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 EDK36741.2 - 3.8e-38 131.2 0.0 5.5e-38 130.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 EDK36741.2 - 1e-20 73.6 0.5 5.4e-20 71.2 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EDK36741.2 - 5.7e-08 32.4 0.0 1.4e-07 31.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like YukC PF10140.9 EDK36741.2 - 0.00014 20.9 0.3 0.00026 20.0 0.3 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.22 EDK36741.2 - 0.00019 21.1 0.2 0.00035 20.2 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EDK36741.2 - 0.0013 17.8 0.4 0.0022 17.0 0.4 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDK36741.2 - 0.0051 16.2 0.1 0.0096 15.3 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1421 PF07223.11 EDK36741.2 - 0.026 14.4 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain (DUF1421) DUF2443 PF10398.9 EDK36741.2 - 0.067 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) APH PF01636.23 EDK36741.2 - 0.068 13.1 0.2 0.17 11.7 0.2 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family CPSF73-100_C PF11718.8 EDK36741.2 - 0.5 9.9 2.7 1.1 8.8 2.3 1.5 1 1 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term PWI PF01480.17 EDK36742.2 - 2.3e-15 56.7 0.3 3.1e-15 56.2 0.3 1.2 1 0 0 1 1 1 1 PWI domain RR_TM4-6 PF06459.12 EDK36742.2 - 0.28 11.0 11.8 0.35 10.7 11.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peroxin-13_N PF04088.13 EDK36742.2 - 1.3 9.3 3.5 2.9 8.2 3.5 1.6 1 1 0 1 1 1 0 Peroxin 13, N-terminal region CDC45 PF02724.14 EDK36742.2 - 6.1 5.0 18.6 7.3 4.7 18.6 1.0 1 0 0 1 1 1 0 CDC45-like protein YTH PF04146.15 EDK36743.2 - 1.3e-40 139.0 0.3 2.8e-40 138.0 0.3 1.6 1 0 0 1 1 1 1 YT521-B-like domain COQ7 PF03232.13 EDK36744.2 - 1.6e-75 252.6 0.0 2.1e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EDK36744.2 - 0.012 16.0 0.0 0.054 13.9 0.0 1.9 2 0 0 2 2 2 0 Rubrerythrin Nuf2 PF03800.14 EDK36745.2 - 5.1e-46 156.3 0.4 5.1e-46 156.3 0.4 2.4 2 1 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 EDK36745.2 - 1e-19 70.7 22.9 1e-19 70.7 22.9 4.3 2 2 2 4 4 4 1 Designed helical repeat protein 10 domain Bacillus_HBL PF05791.11 EDK36745.2 - 0.017 14.9 1.9 0.017 14.9 1.9 4.3 1 1 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) APG6_N PF17675.1 EDK36745.2 - 0.12 12.8 63.1 0.17 12.4 15.8 4.1 2 2 1 3 3 3 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EDK36745.2 - 0.92 9.6 61.1 0.081 13.0 25.1 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EDK36745.2 - 1.9 5.9 46.1 2.8 5.3 46.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF745 PF05335.13 EDK36745.2 - 2.9 7.6 36.8 0.36 10.5 6.2 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF745) GAS PF13851.6 EDK36745.2 - 5.2 6.4 59.4 0.03 13.7 21.7 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding OmpH PF03938.14 EDK36745.2 - 9 6.6 55.7 3.2 8.1 7.2 3.7 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) MFS_1 PF07690.16 EDK36746.2 - 2.3e-27 95.8 42.3 1.2e-26 93.4 41.5 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK36746.2 - 9.9e-09 34.2 22.3 1.5e-08 33.5 22.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK36746.2 - 5.3e-05 22.3 8.2 5.3e-05 22.3 8.2 3.3 3 1 1 4 4 4 1 Sugar (and other) transporter TMEM100 PF16311.5 EDK36746.2 - 0.03 13.9 0.8 0.089 12.4 0.5 2.0 1 1 0 1 1 1 0 Transmembrane protein 100 DUF3483 PF11982.8 EDK36746.2 - 4.1 7.0 8.4 0.22 11.1 1.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3483) GPR_Gpa2_C PF11970.8 EDK36747.2 - 2.3e-31 107.7 4.3 4e-31 106.9 4.3 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Git3 PF11710.8 EDK36748.1 - 5.3e-72 241.8 12.7 6e-72 241.7 12.7 1.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EDK36748.1 - 5.3e-05 22.7 5.5 6.7e-05 22.3 5.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) AA_permease PF00324.21 EDK36750.2 - 7.7e-102 341.3 25.7 9.4e-102 341.1 25.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK36750.2 - 3.1e-21 75.7 29.0 4e-21 75.3 29.0 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2070 PF09843.9 EDK36750.2 - 6.1 5.0 15.7 0.051 11.9 6.8 1.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2070) Sod_Cu PF00080.20 EDK36751.2 - 4.3e-16 59.4 0.1 6.7e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Abhydro_lipase PF04083.16 EDK36752.2 - 3.1e-22 77.9 0.1 6.9e-22 76.8 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDK36752.2 - 3.8e-21 75.9 0.2 6.8e-21 75.1 0.2 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK36752.2 - 6e-05 22.4 0.0 0.001 18.4 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EDK36752.2 - 0.011 15.5 0.1 3.9 7.2 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 EDK36752.2 - 0.064 12.9 0.0 5.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DUF1770 PF08589.10 EDK36752.2 - 0.11 13.5 0.0 0.23 12.4 0.0 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1770) zf-C2H2_2 PF12756.7 EDK36753.2 - 0.0065 16.8 2.3 0.014 15.7 2.3 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) RNA_pol_3_Rpc31 PF11705.8 EDK36753.2 - 0.028 14.7 22.4 0.048 13.9 22.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 EDK36753.2 - 0.042 12.1 16.0 0.064 11.5 16.0 1.2 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 EDK36753.2 - 0.05 13.9 5.8 0.095 13.0 5.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CNDH2_C PF16858.5 EDK36753.2 - 0.12 12.2 9.1 0.19 11.6 9.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2457 PF10446.9 EDK36753.2 - 0.13 11.4 26.9 0.2 10.8 26.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 EDK36753.2 - 0.14 11.5 14.5 0.19 11.0 14.5 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EDK36753.2 - 0.14 10.4 11.5 0.19 10.0 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.13 EDK36753.2 - 0.15 10.7 13.3 0.19 10.2 13.3 1.1 1 0 0 1 1 1 0 Utp14 protein zf-C2H2 PF00096.26 EDK36753.2 - 0.27 11.8 9.4 0.31 11.6 1.9 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type DNA_pol_phi PF04931.13 EDK36753.2 - 0.89 7.6 24.0 1.2 7.2 24.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EDK36753.2 - 1.1 8.6 17.1 1.5 8.2 17.1 1.1 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 EDK36753.2 - 1.2 8.8 10.2 2.7 7.7 10.2 1.6 1 0 0 1 1 1 0 FAM176 family FYDLN_acid PF09538.10 EDK36753.2 - 3.3 8.4 23.2 8.4 7.1 23.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PPP4R2 PF09184.11 EDK36753.2 - 3.5 7.1 19.9 5.9 6.4 19.9 1.3 1 0 0 1 1 1 0 PPP4R2 zf-BED PF02892.15 EDK36753.2 - 5.5 7.1 6.4 21 5.3 6.4 2.1 1 1 0 1 1 1 0 BED zinc finger NPR3 PF03666.13 EDK36753.2 - 6.5 5.4 10.4 9.2 4.9 10.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2_4 PF13894.6 EDK36753.2 - 7.4 7.7 8.1 1.1e+02 4.1 0.1 3.6 2 1 0 2 2 2 0 C2H2-type zinc finger CENP-B_dimeris PF09026.10 EDK36753.2 - 8.9 6.8 27.6 32 5.0 27.6 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-C2H2 PF00096.26 EDK36755.2 - 0.00034 20.9 8.1 0.032 14.7 0.1 3.4 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 EDK36755.2 - 0.02 15.2 3.3 0.061 13.6 2.2 2.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding HCV_NS5a_C PF12941.7 EDK36755.2 - 0.17 11.7 1.2 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 HCV NS5a protein C-terminal region zf_ZIC PF18366.1 EDK36755.2 - 0.17 12.0 1.1 0.44 10.7 0.1 2.2 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_4 PF13894.6 EDK36755.2 - 0.24 12.3 0.2 0.24 12.3 0.2 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK36755.2 - 0.45 11.0 4.7 0.45 11.0 1.2 2.5 2 0 0 2 2 2 0 Zinc-finger double domain BCDHK_Adom3 PF10436.9 EDK36756.2 - 1.9e-42 144.8 0.0 4.1e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDK36756.2 - 1.4e-06 28.7 0.0 2.3e-05 24.9 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDK36756.2 - 0.00063 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CRC_subunit PF08624.10 EDK36757.2 - 6.5e-50 169.1 0.1 1.1e-49 168.3 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Drc1-Sld2 PF11719.8 EDK36757.2 - 0.32 10.5 12.4 0.5 9.9 12.4 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein SPT6_acidic PF14632.6 EDK36757.2 - 0.43 11.2 28.7 23 5.7 16.6 2.6 1 1 1 2 2 2 0 Acidic N-terminal SPT6 YL1 PF05764.13 EDK36757.2 - 0.57 10.3 17.8 1 9.4 17.8 1.5 1 0 0 1 1 1 0 YL1 nuclear protein FRQ PF09421.10 EDK36757.2 - 1 7.3 10.1 1.5 6.8 10.1 1.2 1 0 0 1 1 1 0 Frequency clock protein CDC27 PF09507.10 EDK36757.2 - 2.4 7.5 19.5 4.4 6.6 19.5 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 EDK36757.2 - 2.5 6.2 20.5 3.5 5.7 20.5 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDK36757.2 - 2.8 7.3 21.0 4.4 6.6 21.0 1.3 1 0 0 1 1 1 0 SDA1 MCM_bind PF09739.9 EDK36757.2 - 4.6 5.6 5.9 6.3 5.1 5.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor BUD22 PF09073.10 EDK36757.2 - 6.7 5.9 19.4 9.2 5.5 19.4 1.2 1 0 0 1 1 1 0 BUD22 HUN PF08729.10 EDK36758.2 - 7e-08 32.3 0.1 7e-08 32.3 0.1 2.6 3 1 0 3 3 3 1 HPC2 and ubinuclein domain DUF2370 PF10176.9 EDK36759.2 - 1.4e-82 276.7 0.6 2.4e-82 276.0 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2370) TMEM51 PF15345.6 EDK36759.2 - 0.021 14.7 0.3 0.085 12.7 0.0 2.2 2 1 0 2 2 2 0 Transmembrane protein 51 adh_short PF00106.25 EDK36760.2 - 1.4e-46 158.5 0.8 1.9e-46 158.0 0.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK36760.2 - 7.3e-35 120.6 0.4 1.1e-34 120.0 0.3 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK36760.2 - 1.2e-10 41.6 0.1 2.1e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK36760.2 - 4.3e-05 23.1 0.1 8.9e-05 22.1 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EDK36760.2 - 0.00017 21.0 0.0 0.00029 20.3 0.0 1.3 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 EDK36760.2 - 0.013 14.6 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EDK36760.2 - 0.015 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Spindle_Spc25 PF08234.12 EDK36760.2 - 0.034 14.3 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 Chromosome segregation protein Spc25 SNF5 PF04855.12 EDK36761.2 - 1.3e-44 152.7 5.2 6.2e-29 101.5 0.0 2.5 2 1 1 3 3 3 2 SNF5 / SMARCB1 / INI1 zf-C2H2_assoc PF16606.5 EDK36761.2 - 0.014 15.6 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers Com_YlbF PF06133.11 EDK36761.2 - 4.8 7.8 8.0 1.4 9.6 1.3 2.8 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DNA_pol_B PF00136.21 EDK36762.2 - 2.4e-118 395.8 2.9 3.3e-118 395.3 2.9 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EDK36762.2 - 4.3e-64 215.7 1.1 7.5e-64 214.9 1.1 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EDK36762.2 - 5.4e-39 134.3 0.0 1.1e-38 133.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EDK36762.2 - 2.2e-22 78.9 9.4 7.6e-22 77.2 9.4 2.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DUF1744 PF08490.12 EDK36762.2 - 0.087 11.4 0.1 0.14 10.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) ABC_sub_bind PF04392.12 EDK36763.2 - 0.018 14.3 1.2 0.073 12.3 1.2 1.9 1 1 0 1 1 1 0 ABC transporter substrate binding protein Syntaxin_2 PF14523.6 EDK36764.2 - 2.1e-19 69.7 13.8 2.1e-19 69.7 13.8 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EDK36764.2 - 1.3e-14 53.9 0.2 6.2e-14 51.7 0.2 2.3 1 0 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.21 EDK36764.2 - 0.00016 21.4 0.5 0.00016 21.4 0.5 2.8 3 1 1 4 4 4 1 Synaptobrevin Cep57_CLD_2 PF14197.6 EDK36764.2 - 0.00018 21.5 0.5 0.00018 21.5 0.5 3.9 3 2 0 3 3 3 1 Centrosome localisation domain of PPC89 Syntaxin PF00804.25 EDK36764.2 - 0.00077 19.2 22.6 0.0023 17.7 22.5 1.9 1 1 0 1 1 1 1 Syntaxin ApoO PF09769.9 EDK36764.2 - 0.036 14.0 12.0 0.49 10.4 0.1 3.5 2 1 2 4 4 4 0 Apolipoprotein O BatA PF07584.11 EDK36764.2 - 0.17 12.3 0.0 0.56 10.6 0.0 1.9 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF883 PF05957.13 EDK36764.2 - 0.23 12.1 11.4 0.13 12.9 1.4 3.4 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Rx_N PF18052.1 EDK36764.2 - 0.84 9.9 8.8 2.2 8.6 0.2 3.2 2 1 1 3 3 3 0 Rx N-terminal domain Orf78 PF06024.12 EDK36764.2 - 1.2 9.4 0.0 1.2 9.4 0.0 3.0 2 1 1 3 3 3 0 Orf78 (ac78) T2SSF PF00482.23 EDK36764.2 - 8.3 6.4 5.9 9.9 6.1 3.4 2.3 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF1664 PF07889.12 EDK36764.2 - 9.3 6.3 21.2 2.8 8.0 3.6 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) AATase PF07247.12 EDK36765.2 - 3.6e-33 114.9 5.3 1.1e-32 113.2 5.3 1.8 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EDK36765.2 - 0.0059 15.3 1.0 0.57 8.8 0.1 2.1 2 0 0 2 2 2 2 Condensation domain Voltage_CLC PF00654.20 EDK36766.2 - 6.8e-87 292.0 21.0 6.8e-87 292.0 21.0 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EDK36766.2 - 3.3e-11 43.4 0.1 4.8e-05 23.7 0.0 2.6 2 0 0 2 2 2 2 CBS domain FixQ PF05545.11 EDK36766.2 - 0.51 10.3 2.7 1 9.3 0.6 2.6 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF4052 PF13261.6 EDK36766.2 - 1.9 8.2 7.5 0.21 11.4 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4052) Urb2 PF10441.9 EDK36767.2 - 1.1e-48 165.9 6.5 1.1e-48 165.9 6.5 3.9 3 1 0 3 3 3 1 Urb2/Npa2 family SPG48 PF14764.6 EDK36767.2 - 0.008 16.6 2.7 12 6.4 0.0 4.8 4 0 0 4 4 4 2 AP-5 complex subunit, vesicle trafficking Ribosomal_L7Ae PF01248.26 EDK36768.1 - 2.2e-26 91.4 0.0 2.6e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDK36768.1 - 0.00037 20.3 0.0 0.0005 19.9 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EDK36768.1 - 0.0011 19.1 0.0 0.0011 19.0 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Pico_P2B PF01552.17 EDK36768.1 - 0.052 13.7 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 Picornavirus 2B protein ATP-synt_C PF00137.21 EDK36769.1 - 1.3e-24 86.3 24.6 7.3e-23 80.7 13.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C SpoIIIAC PF06686.11 EDK36769.1 - 0.056 13.6 6.0 0.74 10.0 0.1 2.8 1 1 1 2 2 2 0 Stage III sporulation protein AC/AD protein family Nucleopor_Nup85 PF07575.13 EDK36770.2 - 2.3e-82 277.4 6.0 3.4e-82 276.9 6.0 1.1 1 0 0 1 1 1 1 Nup85 Nucleoporin AATF-Che1 PF13339.6 EDK36770.2 - 0.012 16.3 0.0 0.14 12.9 0.0 2.5 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor HECT PF00632.25 EDK36772.2 - 1.1e-80 271.5 0.1 1.7e-80 270.8 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) C1_2 PF03107.16 EDK36772.2 - 0.13 12.6 2.4 0.43 10.9 2.4 1.8 1 0 0 1 1 1 0 C1 domain Rieske PF00355.26 EDK36773.1 - 6.4e-11 42.1 0.0 1.3e-10 41.1 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EDK36773.1 - 7.4e-11 42.4 0.5 1.7e-10 41.2 0.5 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Transp_cyt_pur PF02133.15 EDK36773.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin Podoplanin PF05808.11 EDK36774.1 - 0.17 12.0 0.2 0.22 11.6 0.2 1.1 1 0 0 1 1 1 0 Podoplanin CYYR1 PF10873.8 EDK36774.1 - 0.77 10.2 11.9 1.4 9.4 11.9 1.4 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Mito_carr PF00153.27 EDK36777.2 - 6.1e-30 103.0 0.9 1.1e-14 54.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CFIA_Pcf11 PF11526.8 EDK36778.2 - 2.5e-14 53.5 7.5 1.8e-12 47.6 7.5 2.6 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.19 EDK36778.2 - 0.023 14.5 0.0 0.077 12.8 0.0 1.9 1 0 0 1 1 1 0 VHS domain CTD_bind PF04818.13 EDK36778.2 - 0.057 14.2 0.1 0.25 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II-binding domain. zf_UBZ PF18439.1 EDK36778.2 - 0.34 10.6 6.0 0.14 11.8 1.7 2.6 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger ADK PF00406.22 EDK36779.1 - 6.3e-61 204.9 0.1 8.5e-61 204.5 0.1 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDK36779.1 - 1.4e-21 77.3 0.7 8e-21 74.9 0.1 2.1 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 EDK36779.1 - 2.7e-17 62.4 0.0 7e-17 61.1 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDK36779.1 - 4e-05 24.2 0.0 9.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK36779.1 - 0.0005 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain CART PF06373.11 EDK36779.1 - 0.02 15.1 0.1 0.098 12.9 0.0 2.2 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) Cytidylate_kin PF02224.18 EDK36779.1 - 0.031 14.0 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 EDK36779.1 - 0.058 13.1 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDK36779.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Say1_Mug180 PF10340.9 EDK36780.2 - 1.3e-23 83.5 0.0 1.7e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDK36780.2 - 6.1e-12 45.8 0.0 9.9e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EDK36780.2 - 0.21 10.4 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family Say1_Mug180 PF10340.9 EDK36781.2 - 5.4e-27 94.6 0.0 8.4e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDK36781.2 - 7.6e-15 55.3 0.0 1.5e-14 54.4 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK36781.2 - 0.051 12.8 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 EDK36782.2 - 8.9e-32 110.4 0.1 1.4e-31 109.7 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDK36782.2 - 5.1e-13 49.4 0.0 8.7e-13 48.6 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK36782.2 - 0.034 13.4 0.0 0.054 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Malic_M PF03949.15 EDK36783.2 - 3.1e-86 288.9 0.0 4.1e-86 288.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EDK36783.2 - 1.3e-62 210.9 0.0 2.1e-62 210.1 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Fapy_DNA_glyco PF01149.24 EDK36784.2 - 8e-20 71.6 0.1 1.9e-19 70.4 0.1 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EDK36784.2 - 2.7e-12 46.5 0.0 6.5e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Polo_box_3 PF18544.1 EDK36784.2 - 0.038 14.6 0.1 0.038 14.6 0.1 2.4 2 0 0 2 2 2 0 Polo box domain FAM178 PF14816.6 EDK36784.2 - 0.16 10.9 1.8 0.26 10.2 1.8 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 Snf7 PF03357.21 EDK36785.2 - 1.3e-43 148.6 17.1 1.6e-43 148.3 17.1 1.1 1 0 0 1 1 1 1 Snf7 DUF2120 PF09893.9 EDK36785.2 - 0.0025 17.9 3.0 0.0025 17.9 3.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2120) Vps4_C PF09336.10 EDK36785.2 - 0.051 13.6 0.8 0.11 12.5 0.8 1.5 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain CLZ PF16526.5 EDK36785.2 - 0.077 13.4 0.0 0.077 13.4 0.0 3.4 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 EDK36785.2 - 0.11 13.0 12.2 5 7.7 0.0 3.9 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein EMP24_GP25L PF01105.24 EDK36785.2 - 0.25 11.3 4.3 2.8 7.8 0.0 2.5 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF3080 PF11279.8 EDK36785.2 - 0.67 9.1 10.3 0.073 12.3 0.6 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF3080) FlaC_arch PF05377.11 EDK36785.2 - 0.8 10.2 9.3 5.9 7.4 0.0 4.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) LMBR1 PF04791.16 EDK36785.2 - 2.2 7.1 5.5 2.6 6.9 5.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 EDK36785.2 - 2.9 6.9 10.3 5.9 5.9 10.3 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cep57_MT_bd PF06657.13 EDK36785.2 - 4.8 7.7 12.3 2.6 8.6 4.4 2.8 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Methyltransf_23 PF13489.6 EDK36786.2 - 1.2e-21 77.3 0.0 1.7e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK36786.2 - 1.8e-15 57.4 0.0 2.7e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK36786.2 - 2.9e-14 53.6 0.0 4.5e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK36786.2 - 1.7e-13 50.6 0.0 2.2e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK36786.2 - 1.9e-13 50.9 0.0 2.8e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDK36786.2 - 3.1e-09 36.5 0.1 4e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EDK36786.2 - 2.5e-07 30.4 0.0 3.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 EDK36786.2 - 2e-06 27.6 0.0 2.6e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EDK36786.2 - 2e-06 27.4 0.0 3.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 EDK36786.2 - 2.4e-05 23.5 0.0 3.5e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 EDK36786.2 - 3.4e-05 23.5 0.1 5.6e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 EDK36786.2 - 0.00027 20.8 0.0 0.0028 17.4 0.0 2.2 1 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EDK36786.2 - 0.0012 18.8 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EDK36786.2 - 0.0047 16.9 0.1 0.0071 16.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 EDK36786.2 - 0.011 15.1 0.3 0.018 14.5 0.3 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain DREV PF05219.12 EDK36786.2 - 0.02 14.0 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_2 PF00891.18 EDK36786.2 - 0.13 11.6 0.0 0.47 9.7 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain YL1 PF05764.13 EDK36787.2 - 1.2e-35 123.8 50.8 8.5e-25 88.3 20.6 2.1 1 1 1 2 2 2 2 YL1 nuclear protein PI3K_1B_p101 PF10486.9 EDK36787.2 - 0.15 9.8 17.9 0.19 9.4 17.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GREB1 PF15782.5 EDK36787.2 - 0.59 7.2 16.8 0.69 7.0 16.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer YL1_C PF08265.11 EDK36788.2 - 1.9e-09 37.1 0.0 4.5e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain ALMT PF11744.8 EDK36788.2 - 3.8 6.2 5.1 6.1 5.5 5.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter MFS_1 PF07690.16 EDK36790.2 - 1.4e-39 136.1 29.7 1.4e-39 136.1 29.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Mpv17_PMP22 PF04117.12 EDK36791.2 - 7.4e-09 35.7 1.4 7.4e-09 35.7 1.4 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family DEAD PF00270.29 EDK36792.2 - 1.5e-34 119.3 1.4 2.9e-34 118.4 1.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK36792.2 - 2e-29 102.2 0.7 5.2e-28 97.6 0.0 3.0 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK36792.2 - 1.5e-05 25.0 0.0 4.8e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DnaI_N PF07319.11 EDK36792.2 - 0.019 15.6 0.7 0.35 11.6 0.1 2.8 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus Form_Nir_trans PF01226.17 EDK36793.2 - 3.3e-58 196.8 27.1 4.2e-58 196.5 27.1 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter zf-C3HC4_2 PF13923.6 EDK36794.2 - 4.8e-10 39.1 14.9 4.8e-10 39.1 11.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK36794.2 - 1.6e-07 31.1 12.8 1.6e-07 31.1 12.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK36794.2 - 2.6e-07 30.5 5.8 2.6e-07 30.5 5.8 2.9 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDK36794.2 - 8e-07 28.8 12.8 4.3e-05 23.3 9.2 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EDK36794.2 - 1.3e-06 28.2 2.3 1.3e-06 28.2 2.3 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EDK36794.2 - 1.4e-06 28.5 11.6 1.4e-06 28.5 11.6 2.4 2 0 0 2 2 2 1 Ring finger domain SAP PF02037.27 EDK36794.2 - 2.7e-06 27.0 0.1 1.1e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 SAP domain zf-RING_10 PF16685.5 EDK36794.2 - 5.5e-06 26.4 9.1 1.2e-05 25.3 9.1 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_3 PF13920.6 EDK36794.2 - 7.6e-06 25.7 14.7 1.2e-05 25.1 9.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK36794.2 - 8.6e-06 25.8 12.0 8.6e-06 25.8 12.0 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EDK36794.2 - 1.5e-05 24.8 14.7 6.3e-05 22.8 11.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDK36794.2 - 7.8e-05 22.9 8.9 7.8e-05 22.9 8.9 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain Rad50_zn_hook PF04423.14 EDK36794.2 - 0.015 15.1 0.2 3.9 7.4 0.0 3.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Nse PF11789.8 EDK36794.2 - 0.063 13.1 10.1 0.14 12.0 7.2 2.5 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DUF3704 PF12488.8 EDK36794.2 - 0.13 12.0 1.6 0.27 10.9 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) zf-ANAPC11 PF12861.7 EDK36794.2 - 0.24 11.5 5.9 0.11 12.5 3.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Sgf11 PF08209.11 EDK36794.2 - 1.6 8.3 6.1 0.41 10.2 0.6 2.8 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-piccolo PF05715.13 EDK36794.2 - 3.7 7.8 11.5 25 5.1 2.9 3.4 3 0 0 3 3 3 0 Piccolo Zn-finger zf-P11 PF03854.14 EDK36794.2 - 8.1 6.2 13.7 5.2 6.8 9.8 2.6 2 1 0 2 2 2 0 P-11 zinc finger DUF1272 PF06906.11 EDK36794.2 - 8.2 6.6 10.1 2.6 8.2 6.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) ANAPC4_WD40 PF12894.7 EDK36795.2 - 2.6e-08 34.0 0.0 8.4e-07 29.2 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK36795.2 - 7.7e-05 23.4 1.0 0.00084 20.1 0.0 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat Phos_pyr_kin PF08543.12 EDK36796.2 - 1.1e-08 34.8 0.0 1.8e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase DNA_ligase_A_M PF01068.21 EDK36796.2 - 0.15 11.7 0.1 0.29 10.8 0.1 1.5 1 1 0 1 1 1 0 ATP dependent DNA ligase domain Lipase_3 PF01764.25 EDK36797.2 - 6.4e-07 29.3 0.0 1.3e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EDK36797.2 - 0.0018 18.9 0.0 0.0031 18.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family SUR7 PF06687.12 EDK36798.2 - 1.8e-38 132.3 16.2 2.2e-38 132.0 16.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EDK36798.2 - 6.5e-05 22.9 4.2 6.5e-05 22.9 4.2 1.5 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF5134 PF17197.4 EDK36798.2 - 0.078 12.9 2.2 0.12 12.2 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) UbiA PF01040.18 EDK36798.2 - 2.6 7.3 16.2 0.059 12.7 8.6 1.9 2 0 0 2 2 2 0 UbiA prenyltransferase family DUF3742 PF12553.8 EDK36798.2 - 9.7 6.3 8.7 0.37 10.9 1.6 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3742) Pkinase PF00069.25 EDK36799.1 - 1.5e-36 126.1 0.0 2.3e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36799.1 - 6.9e-22 78.0 0.0 1.4e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36799.1 - 9.5e-05 21.8 0.0 0.00022 20.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EDK36799.1 - 0.0039 16.8 0.1 0.36 10.4 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EDK36799.1 - 0.012 14.6 0.0 0.012 14.6 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EDK36799.1 - 0.038 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EDK36799.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EDK36799.1 - 0.086 11.6 0.1 0.42 9.3 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Fmp27 PF10344.9 EDK36800.2 - 5.4e-231 769.3 37.5 5.4e-231 769.3 37.5 2.7 3 0 0 3 3 3 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 EDK36800.2 - 8.8e-110 367.8 16.7 8.8e-110 367.8 16.7 2.4 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EDK36800.2 - 3.8e-76 256.9 18.0 2.3e-43 148.8 5.5 4.2 3 1 1 4 4 4 2 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EDK36800.2 - 1.7e-58 197.2 0.0 4.1e-58 195.9 0.0 1.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EDK36800.2 - 1.4e-45 155.0 0.4 5.5e-45 153.1 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EDK36800.2 - 3.6e-21 75.8 0.0 4.1e-20 72.4 0.0 3.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain RRM_1 PF00076.22 EDK36801.2 - 4.3e-10 39.3 0.0 1.1e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EDK36802.2 - 1.3e-11 44.6 6.2 2.1e-11 44.0 6.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK36802.2 - 3.6e-08 33.1 6.6 5.8e-08 32.5 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDK36802.2 - 1.5e-07 31.1 1.0 2.7e-07 30.2 1.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EDK36802.2 - 2.1e-06 27.6 0.9 6e-06 26.2 1.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDK36802.2 - 6.2e-06 26.1 4.7 9.7e-06 25.5 4.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDK36802.2 - 7.7e-06 25.7 5.3 1.3e-05 25.0 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDK36802.2 - 1.2e-05 25.5 7.7 3.8e-05 23.9 7.7 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDK36802.2 - 0.0001 22.3 2.4 0.00019 21.4 2.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EDK36802.2 - 0.0014 18.3 6.2 0.0028 17.2 6.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EDK36802.2 - 0.004 17.0 4.3 0.0064 16.3 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EDK36802.2 - 0.015 15.1 5.8 0.026 14.4 5.8 1.4 1 0 0 1 1 1 0 PHD-finger 2OG-Fe_Oxy_2 PF10014.9 EDK36802.2 - 0.027 14.3 0.6 0.05 13.4 0.6 1.4 1 0 0 1 1 1 0 2OG-Fe dioxygenase Prok-RING_1 PF14446.6 EDK36802.2 - 0.041 13.8 5.7 0.16 11.9 5.7 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Zf_RING PF16744.5 EDK36802.2 - 0.054 13.6 3.8 0.13 12.4 3.8 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_4 PF14447.6 EDK36802.2 - 0.059 13.2 3.4 0.13 12.1 3.4 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 DUF5453 PF17534.2 EDK36802.2 - 0.11 12.4 0.4 0.19 11.6 0.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5453) zf-RING_4 PF14570.6 EDK36802.2 - 0.33 10.8 6.3 0.6 9.9 6.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 EDK36802.2 - 1.4 9.0 5.9 2.9 8.0 5.9 1.6 1 0 0 1 1 1 0 Zinc-finger zf-C3HC4_4 PF15227.6 EDK36802.2 - 2 8.6 5.7 3.8 7.7 5.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EDK36802.2 - 2.5 8.3 6.7 4.7 7.4 6.7 1.5 1 0 0 1 1 1 0 RING-variant domain eIF-5a PF01287.20 EDK36803.1 - 1.3e-31 108.5 0.8 1.8e-31 108.1 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EDK36803.1 - 0.12 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain PWWP PF00855.17 EDK36804.2 - 1.1e-18 67.4 0.1 2.5e-18 66.3 0.1 1.6 1 0 0 1 1 1 1 PWWP domain Med26 PF08711.11 EDK36804.2 - 3.7e-08 33.3 0.0 8.6e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain PI3K_1B_p101 PF10486.9 EDK36804.2 - 0.059 11.1 5.1 0.078 10.7 5.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Lin-8 PF03353.15 EDK36804.2 - 0.56 9.7 8.6 0.96 9.0 8.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SDA1 PF05285.12 EDK36804.2 - 1.5 8.1 23.6 3.1 7.1 23.6 1.5 1 0 0 1 1 1 0 SDA1 Smg4_UPF3 PF03467.15 EDK36804.2 - 1.6 8.7 10.3 1.6 8.7 5.2 2.4 2 0 0 2 2 2 0 Smg-4/UPF3 family Nop14 PF04147.12 EDK36804.2 - 3 5.9 24.8 4.5 5.4 24.8 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EDK36804.2 - 8 5.7 22.9 13 5.0 22.9 1.3 1 0 0 1 1 1 0 BUD22 Colicin_im PF03857.13 EDK36806.2 - 0.0019 18.2 0.7 0.0038 17.2 0.7 1.5 1 0 0 1 1 1 1 Colicin immunity protein DNApol_Exo PF18136.1 EDK36807.2 - 1.8e-99 332.5 0.0 3.7e-99 331.4 0.0 1.5 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EDK36807.2 - 7.4e-57 193.1 0.0 1.4e-56 192.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A MFS_1 PF07690.16 EDK36808.2 - 2e-25 89.5 21.1 3e-19 69.1 5.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK36808.2 - 1.3e-05 24.3 7.1 1.3e-05 24.3 7.1 2.7 2 1 0 3 3 3 1 Sugar (and other) transporter FMN_red PF03358.15 EDK36808.2 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 NADPH-dependent FMN reductase UNC-93 PF05978.16 EDK36808.2 - 9.8 5.9 16.8 0.016 14.9 3.1 2.9 3 1 1 4 4 4 0 Ion channel regulatory protein UNC-93 zf-H2C2_2 PF13465.6 EDK36810.2 - 0.00057 20.2 7.4 0.00057 20.2 7.4 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDK36810.2 - 0.017 15.5 17.1 0.29 11.7 2.3 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK36810.2 - 0.023 15.5 17.5 0.99 10.4 7.0 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger HeLo PF14479.6 EDK36811.2 - 0.019 14.8 0.4 0.028 14.3 0.4 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation SPX PF03105.19 EDK36811.2 - 0.23 11.4 12.2 0.27 11.1 12.2 1.2 1 0 0 1 1 1 0 SPX domain TMF_DNA_bd PF12329.8 EDK36811.2 - 0.44 10.6 4.7 9.7 6.3 0.9 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SelP_N PF04592.14 EDK36811.2 - 0.76 9.1 9.8 1.3 8.4 9.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RTBV_P12 PF06361.11 EDK36811.2 - 3.4 8.1 6.5 1.1 9.7 1.9 2.4 3 1 1 4 4 4 0 Rice tungro bacilliform virus P12 protein Trypsin_2 PF13365.6 EDK36812.2 - 7.5e-14 52.9 0.0 1.4e-13 52.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EDK36812.2 - 0.00032 20.6 0.0 0.0006 19.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin zf-BED PF02892.15 EDK36813.2 - 4.2e-06 26.7 0.2 1.1e-05 25.3 0.2 1.7 1 0 0 1 1 1 1 BED zinc finger RbpA PF13397.6 EDK36813.2 - 0.025 15.2 0.1 0.078 13.6 0.1 1.8 1 0 0 1 1 1 0 RNA polymerase-binding protein PyrI_C PF02748.15 EDK36813.2 - 0.045 13.7 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Arc_trans_TRASH PF08394.10 EDK36813.2 - 0.068 13.5 0.4 0.13 12.6 0.4 1.5 1 0 0 1 1 1 0 Archaeal TRASH domain Hamartin PF04388.12 EDK36814.1 - 4.6 5.8 14.3 5.2 5.6 14.3 1.1 1 0 0 1 1 1 0 Hamartin protein Pkinase PF00069.25 EDK36815.2 - 1.2e-59 201.9 8.7 2.2e-41 142.0 0.0 3.2 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36815.2 - 7.9e-25 87.6 10.0 6.4e-21 74.8 0.0 2.9 2 1 1 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EDK36815.2 - 0.014 15.3 12.6 0.79 9.6 0.2 3.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family PAT1 PF09770.9 EDK36815.2 - 1.3 7.2 55.3 2.7 6.1 55.3 1.6 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ytp1 PF10355.9 EDK36816.2 - 1.5e-105 352.4 7.6 1.5e-105 352.4 7.6 1.5 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDK36816.2 - 4.7e-37 126.0 8.8 4.7e-37 126.0 8.8 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) RRM_5 PF13893.6 EDK36816.2 - 0.012 15.2 0.0 0.063 12.9 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5527 PF17665.1 EDK36816.2 - 0.069 12.7 0.2 0.16 11.5 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5527) S-methyl_trans PF02574.16 EDK36817.2 - 1.3e-64 218.6 0.0 1.4e-64 218.5 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase SNAD2 PF18745.1 EDK36817.2 - 0.076 12.7 0.4 0.43 10.2 0.1 1.9 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 2 MIF4G_like PF09088.11 EDK36818.2 - 3.8e-55 186.6 0.9 8.1e-55 185.6 0.9 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EDK36818.2 - 9.7e-47 159.7 2.2 4.4e-45 154.2 2.2 2.3 1 1 0 1 1 1 1 MIF4G like MIF4G PF02854.19 EDK36818.2 - 0.00048 19.8 0.3 0.00048 19.8 0.3 2.9 3 0 0 3 3 3 1 MIF4G domain ABC_tran PF00005.27 EDK36819.2 - 2.4e-15 57.2 0.0 7e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDK36819.2 - 1.2e-10 41.7 3.9 5.3e-05 23.2 0.5 2.8 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDK36819.2 - 3.3e-05 23.4 0.1 0.18 11.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDK36819.2 - 0.0018 18.8 0.2 0.0035 17.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDK36819.2 - 0.0019 17.9 0.1 0.0037 17.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EDK36819.2 - 0.0055 17.1 0.0 0.044 14.2 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 EDK36819.2 - 0.0059 16.4 0.0 0.0085 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDK36819.2 - 0.0085 16.0 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_13 PF13166.6 EDK36819.2 - 0.028 13.1 0.0 0.04 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDK36819.2 - 0.033 13.8 0.1 0.07 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EDK36819.2 - 0.054 13.4 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EDK36819.2 - 0.077 13.6 0.0 0.19 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDK36819.2 - 0.11 12.9 0.1 0.19 12.1 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_27 PF13514.6 EDK36819.2 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDK36819.2 - 0.13 12.4 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Antimicrobial_6 PF08036.11 EDK36819.2 - 0.14 12.3 0.5 0.25 11.4 0.5 1.3 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide AAA_22 PF13401.6 EDK36819.2 - 0.15 12.4 0.1 0.4 11.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EDK36819.2 - 0.16 12.1 0.1 0.35 11.0 0.0 1.7 2 0 0 2 2 1 0 50S ribosome-binding GTPase MutS_V PF00488.21 EDK36819.2 - 0.21 11.6 0.0 0.9 9.5 0.0 1.9 2 0 0 2 2 2 0 MutS domain V NDK PF00334.19 EDK36820.1 - 5.3e-52 175.4 0.0 6e-52 175.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase WD40 PF00400.32 EDK36821.1 - 2.2e-14 53.6 5.5 0.0015 19.3 0.1 7.5 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36821.1 - 0.012 15.9 0.0 0.54 10.6 0.0 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain SpmSyn_N PF17950.1 EDK36821.1 - 0.014 15.6 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Nup160 PF11715.8 EDK36821.1 - 0.088 11.4 0.0 2 7.0 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Collagen PF01391.18 EDK36821.1 - 3.2 7.6 16.7 9 6.1 16.7 1.8 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) RabGAP-TBC PF00566.18 EDK36822.2 - 5.4e-21 75.2 2.9 1.1e-20 74.2 2.9 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SeqA_N PF17206.3 EDK36822.2 - 0.16 11.3 0.2 0.46 9.8 0.2 1.8 1 0 0 1 1 1 0 SeqA protein N-terminal domain TauD PF02668.16 EDK36823.2 - 1.9e-40 139.3 0.0 4.6e-40 138.1 0.0 1.5 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EDK36823.2 - 1.4e-14 54.5 2.8 1.4e-14 54.4 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF971) Aldo_ket_red PF00248.21 EDK36824.1 - 5.3e-51 173.6 0.0 7.2e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1664 PF07889.12 EDK36825.2 - 3.6e-05 23.8 49.0 0.02 14.9 5.4 5.9 1 1 5 6 6 6 3 Protein of unknown function (DUF1664) HOOK PF05622.12 EDK36825.2 - 5.2e-05 21.6 36.4 5.2e-05 21.6 36.4 2.5 1 1 1 2 2 2 1 HOOK protein ATG16 PF08614.11 EDK36825.2 - 0.00011 22.5 70.5 0.0031 17.8 20.0 5.6 1 1 6 7 7 7 4 Autophagy protein 16 (ATG16) APG6_N PF17675.1 EDK36825.2 - 0.0019 18.7 14.1 0.0019 18.7 14.1 5.8 2 1 3 5 5 3 1 Apg6 coiled-coil region AAA_13 PF13166.6 EDK36825.2 - 0.0035 16.1 20.0 0.0035 16.1 20.0 3.3 1 1 2 3 3 3 3 AAA domain AAA_33 PF13671.6 EDK36825.2 - 0.0039 17.4 0.1 0.051 13.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain UPF0242 PF06785.11 EDK36825.2 - 0.0043 17.2 7.7 0.0043 17.2 7.7 5.1 2 1 3 5 5 4 3 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 EDK36825.2 - 0.0047 15.9 77.4 0.059 12.3 11.8 4.5 1 1 3 4 4 4 3 Spc7 kinetochore protein AAA_22 PF13401.6 EDK36825.2 - 0.0083 16.4 0.0 0.0083 16.4 0.0 3.3 3 1 1 4 4 4 1 AAA domain DHR10 PF18595.1 EDK36825.2 - 0.0098 15.9 4.9 0.0098 15.9 4.9 6.6 1 1 5 6 6 5 1 Designed helical repeat protein 10 domain TMF_TATA_bd PF12325.8 EDK36825.2 - 0.014 15.6 5.8 0.014 15.6 5.8 6.0 2 1 3 6 6 5 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.10 EDK36825.2 - 0.014 15.6 7.0 0.014 15.6 7.0 5.2 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family AAA_5 PF07728.14 EDK36825.2 - 0.02 14.9 1.1 0.17 11.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EDK36825.2 - 0.024 15.2 0.0 0.024 15.2 0.0 4.9 2 1 0 2 2 1 0 ABC transporter BLOC1_2 PF10046.9 EDK36825.2 - 0.025 14.9 51.2 0.068 13.5 2.7 6.6 2 1 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.9 EDK36825.2 - 0.031 14.3 86.5 0.91 9.5 16.7 6.0 1 1 6 7 7 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3800 PF12686.7 EDK36825.2 - 0.035 14.7 3.2 44 4.7 3.2 4.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) FtsK_SpoIIIE PF01580.18 EDK36825.2 - 0.055 12.8 1.4 0.64 9.3 0.0 2.9 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EDK36825.2 - 0.061 12.8 0.3 0.15 11.6 0.0 1.8 2 0 0 2 2 1 0 P-loop containing dynein motor region Collagen_mid PF15984.5 EDK36825.2 - 0.067 12.9 1.2 1.5 8.5 0.1 2.9 1 1 2 3 3 3 0 Bacterial collagen, middle region AAA_29 PF13555.6 EDK36825.2 - 0.082 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF5082 PF16888.5 EDK36825.2 - 0.36 11.1 61.0 1.7 8.9 7.4 6.3 2 2 4 6 6 6 0 Domain of unknown function (DUF5082) AAA_16 PF13191.6 EDK36825.2 - 0.55 10.6 0.0 0.55 10.6 0.0 3.4 3 2 0 3 3 2 0 AAA ATPase domain AAA_19 PF13245.6 EDK36825.2 - 0.67 10.3 4.6 0.85 9.9 0.0 3.2 3 1 0 3 3 3 0 AAA domain CALCOCO1 PF07888.11 EDK36825.2 - 0.7 8.7 68.2 0.034 13.0 9.4 4.2 1 1 3 4 4 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like PKcGMP_CC PF16808.5 EDK36825.2 - 1 9.3 0.0 1 9.3 0.0 10.0 7 2 2 10 10 9 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Filament PF00038.21 EDK36825.2 - 1.7 8.2 70.2 0.0085 15.7 30.2 3.9 2 1 2 4 4 3 0 Intermediate filament protein Bacillus_HBL PF05791.11 EDK36825.2 - 1.8 8.4 45.8 0.11 12.3 3.3 5.7 2 1 3 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) DUF948 PF06103.11 EDK36825.2 - 2.3 8.5 32.7 0.15 12.4 1.3 6.4 2 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF2852 PF11014.8 EDK36825.2 - 3.1 8.0 10.4 0.077 13.2 0.7 3.3 3 0 0 3 3 2 0 Protein of unknown function (DUF2852) MAD PF05557.13 EDK36825.2 - 5.5 5.2 76.5 0.14 10.5 24.9 3.5 1 1 2 3 3 3 0 Mitotic checkpoint protein FUSC PF04632.12 EDK36825.2 - 5.7 5.3 11.8 3.5 6.0 3.1 2.3 2 0 0 2 2 2 0 Fusaric acid resistance protein family GAS PF13851.6 EDK36825.2 - 7.6 5.8 80.8 0.069 12.5 24.4 4.6 2 1 1 4 4 3 0 Growth-arrest specific micro-tubule binding P16-Arc PF04699.14 EDK36826.2 - 3.2e-48 164.0 0.0 3.5e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) RPN13_C PF16550.5 EDK36826.2 - 0.022 14.9 0.5 0.066 13.4 0.3 1.8 2 0 0 2 2 2 0 UCH-binding domain DUF1892 PF08987.10 EDK36827.2 - 1.2e-15 57.7 1.1 1.6e-15 57.3 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) DUF1857 PF08982.11 EDK36827.2 - 0.093 12.6 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1857) PGI PF00342.19 EDK36828.2 - 1.9e-239 795.2 2.9 2.2e-239 795.0 2.9 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Mhr1 PF12829.7 EDK36828.2 - 0.00036 20.6 0.1 0.43 10.7 0.0 2.6 2 1 0 2 2 2 2 Transcriptional regulation of mitochondrial recombination Zn_clus PF00172.18 EDK36831.2 - 1.4e-05 25.2 10.1 2.7e-05 24.2 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease_2 PF13520.6 EDK36832.2 - 6.3e-48 163.7 56.4 7.5e-48 163.4 56.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK36832.2 - 1.5e-18 66.7 48.5 2.1e-18 66.2 48.5 1.1 1 0 0 1 1 1 1 Amino acid permease zf-RING_2 PF13639.6 EDK36833.2 - 1.2e-05 25.5 7.5 3.6e-05 24.0 7.5 1.9 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDK36833.2 - 5.5e-05 23.0 7.9 0.00015 21.7 8.0 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDK36833.2 - 0.00053 20.2 4.9 0.001 19.3 4.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK36833.2 - 0.0009 19.1 4.4 0.0025 17.6 4.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK36833.2 - 0.0018 18.1 9.8 0.011 15.6 9.8 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDK36833.2 - 0.0031 17.2 1.5 0.0031 17.2 1.5 2.3 3 0 0 3 3 3 1 RING-like zinc finger Prok-RING_4 PF14447.6 EDK36833.2 - 0.0034 17.2 2.8 0.0074 16.1 2.8 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDK36833.2 - 0.01 15.8 4.9 0.01 15.8 4.9 1.8 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDK36833.2 - 0.035 14.0 5.7 0.13 12.2 5.7 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1811 PF08838.10 EDK36833.2 - 0.074 13.3 0.0 2.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) zf-C3H2C3 PF17122.5 EDK36833.2 - 0.25 11.4 2.9 0.76 9.9 2.9 1.8 1 0 0 1 1 1 0 Zinc-finger CDC24_OB3 PF17244.2 EDK36833.2 - 0.44 10.2 2.6 0.47 10.1 1.4 1.6 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 DUF1240 PF06836.12 EDK36833.2 - 2.2 8.9 5.2 0.78 10.3 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) BNR PF02012.20 EDK36834.2 - 3.4 8.0 4.8 15 6.1 0.5 2.9 2 0 0 2 2 2 0 BNR/Asp-box repeat Macoilin PF09726.9 EDK36836.2 - 0.65 8.5 11.6 0.73 8.3 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 EDK36836.2 - 1.6 7.6 4.5 10 5.0 5.9 1.5 2 0 0 2 2 2 0 Mitoguardin Apt1 PF10351.9 EDK36836.2 - 8.9 5.0 15.2 11 4.8 15.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 EDK36836.2 - 9.8 6.0 16.0 12 5.7 16.0 1.1 1 0 0 1 1 1 0 SPX domain Cation_efflux PF01545.21 EDK36837.2 - 1.4e-24 87.0 15.3 1.8e-24 86.6 15.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EDK36837.2 - 0.0017 18.4 0.1 0.0034 17.5 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter WD40 PF00400.32 EDK36838.1 - 1.2e-21 76.5 10.7 1.3e-06 29.0 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK36838.1 - 1.2e-11 44.7 0.0 7.2e-06 26.2 0.0 5.3 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 EDK36838.1 - 0.0013 18.5 0.5 0.028 14.2 0.1 2.8 2 1 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 EDK36838.1 - 0.006 16.5 0.8 9.5 6.3 0.0 3.9 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 EDK36838.1 - 0.0093 14.3 0.0 0.016 13.6 0.0 1.5 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EDK36838.1 - 0.015 14.3 0.2 0.22 10.4 0.1 2.9 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK36838.1 - 0.16 11.8 0.0 2.2 8.1 0.0 2.3 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A UPF0121 PF03661.13 EDK36839.2 - 3.5 6.9 10.7 3.4 7.0 4.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0121) DASH_Dad3 PF08656.10 EDK36840.2 - 8.2e-27 93.1 0.2 1.1e-26 92.7 0.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 COG6 PF06419.11 EDK36840.2 - 0.023 12.9 0.5 0.037 12.2 0.0 1.5 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 Lyase_1 PF00206.20 EDK36841.1 - 1.8e-22 80.1 0.0 2.9e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EDK36841.1 - 4.8e-17 62.3 0.0 2.1e-16 60.2 0.0 2.1 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Amidohydro_1 PF01979.20 EDK36841.1 - 0.028 13.7 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase family DUF1331 PF07048.11 EDK36841.1 - 0.042 13.5 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Mid2 PF04478.12 EDK36843.2 - 1.7e-06 27.9 1.3 1.7e-06 27.9 1.3 2.6 1 1 2 3 3 3 1 Mid2 like cell wall stress sensor SKG6 PF08693.10 EDK36843.2 - 6.5e-05 22.2 2.7 6.5e-05 22.2 2.7 2.5 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Apt1 PF10351.9 EDK36843.2 - 0.45 9.3 13.3 0.58 8.9 13.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain GREB1 PF15782.5 EDK36843.2 - 2.6 5.1 16.4 3.2 4.8 16.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF572 PF04502.13 EDK36843.2 - 2.7 7.5 10.7 3.4 7.2 10.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4674 PF15719.5 EDK36843.2 - 9.4 6.2 15.9 15 5.5 15.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Borrelia_P83 PF05262.11 EDK36844.1 - 0.0007 18.2 31.1 0.00083 18.0 31.1 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein PRIMA1 PF16101.5 EDK36844.1 - 0.66 10.0 3.8 1.3 9.1 3.8 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 GREB1 PF15782.5 EDK36844.1 - 0.74 6.9 14.9 0.77 6.8 14.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Epimerase PF01370.21 EDK36845.2 - 2.5e-08 33.7 0.0 3.4e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK36845.2 - 5.7e-06 25.5 0.0 2.4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK36845.2 - 6.4e-06 26.2 0.0 9.2e-05 22.4 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK36845.2 - 0.00017 20.8 0.2 0.00049 19.3 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK36845.2 - 0.048 13.0 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EDK36845.2 - 0.05 12.7 0.0 0.12 11.4 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short PF00106.25 EDK36845.2 - 0.095 12.1 0.1 0.19 11.1 0.1 1.5 1 1 0 1 1 1 0 short chain dehydrogenase HPP PF04982.13 EDK36846.2 - 2.7e-36 124.5 7.5 2.7e-36 124.5 7.5 1.5 2 0 0 2 2 2 1 HPP family E1-E2_ATPase PF00122.20 EDK36847.2 - 3.4e-50 170.1 0.2 3.4e-50 170.1 0.2 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDK36847.2 - 6e-45 153.2 0.4 6e-45 153.2 0.4 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDK36847.2 - 2e-24 87.1 0.4 2.9e-23 83.3 0.4 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDK36847.2 - 6.9e-14 51.3 0.0 1.6e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDK36847.2 - 3.1e-11 43.2 0.0 1e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDK36847.2 - 5.1e-09 36.2 1.6 4.2e-06 26.7 2.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase RseC_MucC PF04246.12 EDK36847.2 - 0.048 13.6 0.1 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF3784 PF12650.7 EDK36847.2 - 0.53 10.5 8.3 4 7.7 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3784) Sua5_yciO_yrdC PF01300.18 EDK36848.2 - 2.3e-50 170.6 0.0 3.9e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EDK36848.2 - 5.8e-33 114.3 0.0 9.2e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Xpo1 PF08389.12 EDK36849.2 - 0.00026 21.1 5.0 0.058 13.5 0.1 5.3 3 1 2 5 5 5 1 Exportin 1-like protein VacA PF02691.15 EDK36849.2 - 0.097 10.5 0.0 0.22 9.3 0.0 1.5 2 0 0 2 2 2 0 Vacuolating cyotoxin Fis1_TPR_C PF14853.6 EDK36850.2 - 1.2e-26 92.5 0.3 2.1e-26 91.7 0.3 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EDK36850.2 - 8.9e-14 50.9 0.1 3.2e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EDK36850.2 - 0.0002 21.2 0.9 0.00047 20.1 0.3 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36850.2 - 0.00032 21.1 0.4 0.00032 21.1 0.4 1.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK36850.2 - 0.0062 17.1 0.5 0.021 15.4 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK36850.2 - 0.017 15.9 0.1 0.067 14.0 0.1 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36850.2 - 0.043 14.5 0.2 0.11 13.2 0.1 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDK36850.2 - 0.061 13.8 0.2 0.12 12.8 0.1 1.5 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation Gram_pos_anchor PF00746.21 EDK36850.2 - 0.32 11.0 2.3 0.55 10.2 2.3 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif A_deamin PF02137.18 EDK36851.2 - 2.8e-29 102.6 0.0 4.6e-29 101.9 0.0 1.3 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank PF00023.30 EDK36852.2 - 2.4e-10 40.4 0.2 0.00034 20.9 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EDK36852.2 - 1.2e-09 37.6 0.1 0.0023 18.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EDK36852.2 - 2.9e-09 37.4 0.2 2.8e-08 34.2 0.1 2.1 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EDK36852.2 - 2.1e-08 34.3 0.1 0.00018 21.7 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDK36852.2 - 3.2e-07 30.7 0.0 3.9e-06 27.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ribul_P_3_epim PF00834.19 EDK36853.2 - 4.4e-70 235.1 0.0 5.1e-70 234.9 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 EDK36853.2 - 0.00041 19.7 0.5 0.0006 19.2 0.5 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG OMPdecase PF00215.24 EDK36853.2 - 0.015 14.9 0.2 0.033 13.8 0.1 1.5 1 1 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 EDK36853.2 - 0.14 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Alb1 PF09135.11 EDK36854.1 - 2.7e-10 41.0 9.7 2.7e-10 41.0 9.7 1.4 2 0 0 2 2 2 1 Alb1 TFR_dimer PF04253.15 EDK36855.2 - 3.1e-22 78.9 0.5 6.1e-22 78.0 0.5 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDK36855.2 - 5.7e-21 75.1 0.0 9.3e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDK36855.2 - 5.3e-12 45.6 0.7 1.2e-11 44.5 0.2 1.8 2 0 0 2 2 2 1 PA domain zf-RING_2 PF13639.6 EDK36856.2 - 0.51 10.7 4.9 2 8.8 4.9 2.1 1 1 0 1 1 1 0 Ring finger domain GREB1 PF15782.5 EDK36857.1 - 4.2 4.4 13.4 4.9 4.1 13.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Telomere_reg-2 PF10193.9 EDK36858.2 - 1.1e-23 83.7 2.2 4.3e-23 81.9 0.1 2.9 3 0 0 3 3 3 1 Telomere length regulation protein Syntaxin-6_N PF09177.11 EDK36858.2 - 0.09 13.3 0.3 18 5.9 0.2 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DNA_pol_A_exo1 PF01612.20 EDK36859.2 - 0.00053 19.7 0.0 0.0016 18.2 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease AP_endonuc_2 PF01261.24 EDK36860.2 - 6.8e-31 107.3 0.0 1.1e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Nucleoporin2 PF04096.14 EDK36861.2 - 2.3e-42 144.6 0.0 3.8e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EDK36861.2 - 6.4e-30 103.8 357.2 1.1e-05 26.2 47.3 10.4 3 2 7 10 10 10 8 Nucleoporin FG repeat region XPG_I PF00867.18 EDK36862.2 - 6.1e-28 97.0 0.2 6.1e-28 97.0 0.2 1.7 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EDK36862.2 - 2.2e-18 66.6 0.0 4.2e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EDK36862.2 - 2.3e-06 28.1 0.0 9.8e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 EDK36862.2 - 0.042 14.0 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EDK36862.2 - 0.08 13.6 0.0 0.27 11.9 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain Proteasome PF00227.26 EDK36863.2 - 4.9e-59 199.0 0.1 6.2e-59 198.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit FumaraseC_C PF10415.9 EDK36864.2 - 3.5e-25 88.2 0.1 6.5e-25 87.3 0.0 1.5 2 0 0 2 2 2 1 Fumarase C C-terminus Lyase_1 PF00206.20 EDK36864.2 - 9.6e-13 48.2 0.8 1.7e-12 47.4 0.8 1.4 1 0 0 1 1 1 1 Lyase DUF4288 PF14119.6 EDK36864.2 - 0.17 12.3 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Lyase_1 PF00206.20 EDK36865.1 - 4.7e-99 331.7 0.0 5.7e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Lyase TEX19 PF15553.6 EDK36865.1 - 0.2 11.6 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 TOM13 PF08219.11 EDK36866.2 - 1.2e-27 95.6 0.0 2.2e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Outer membrane protein TOM13 Hexokinase_2 PF03727.16 EDK36867.2 - 7.6e-78 261.2 0.0 1.1e-77 260.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDK36867.2 - 9.5e-72 241.1 0.0 1.5e-71 240.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 EDK36867.2 - 0.19 11.2 0.0 0.5 9.9 0.0 1.6 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain DUF5315 PF17242.2 EDK36868.2 - 2.7e-20 72.0 0.3 5.3e-20 71.0 0.3 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) GPI2 PF06432.11 EDK36869.2 - 9.9e-81 271.2 12.6 1.1e-80 271.1 12.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF4235 PF14019.6 EDK36869.2 - 0.067 13.3 0.5 0.067 13.3 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) Peptidase_M56 PF05569.11 EDK36869.2 - 0.68 9.1 7.7 0.074 12.2 0.9 2.3 2 1 1 3 3 3 0 BlaR1 peptidase M56 WD40 PF00400.32 EDK36870.2 - 6e-56 185.1 19.2 4.6e-10 39.9 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EDK36870.2 - 2.7e-43 147.3 0.0 4.9e-43 146.5 0.0 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EDK36870.2 - 5.4e-15 55.5 0.2 0.011 16.1 0.0 5.9 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK36870.2 - 4e-07 29.1 0.7 0.013 14.2 0.0 4.0 3 1 1 4 4 4 2 Nucleoporin Nup120/160 LisH PF08513.11 EDK36870.2 - 8.6e-07 28.7 0.1 1.9e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 EDK36870.2 - 1.8e-06 27.1 0.7 0.61 9.0 0.0 4.5 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK36870.2 - 5.6e-06 26.4 0.5 0.004 17.1 0.0 3.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDK36870.2 - 0.0015 18.0 0.0 0.89 8.8 0.0 3.5 4 0 0 4 4 4 1 WD40-like domain p47_phox_C PF08944.11 EDK36870.2 - 0.023 14.1 1.6 0.049 13.1 1.6 1.4 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain SpoIIIAH PF12685.7 EDK36871.1 - 0.84 9.4 10.9 1 9.2 10.9 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein CCDC106 PF15794.5 EDK36871.1 - 8.7 6.0 7.5 11 5.6 7.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SRP1_TIP1 PF00660.17 EDK36872.1 - 1.5e-21 76.3 0.1 2e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family Helo_like_N PF17111.5 EDK36872.1 - 0.036 13.4 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Folliculin PF11704.8 EDK36873.2 - 1.2e-43 149.1 0.2 5.3e-42 143.8 0.1 2.4 2 1 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport Atg14 PF10186.9 EDK36874.2 - 1.5e-10 40.7 0.0 5e-10 39.0 0.0 1.7 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EDK36874.2 - 2.1e-06 26.9 7.8 2.6e-05 23.3 7.8 2.5 1 1 0 1 1 1 1 Vacuolar protein sorting 38 APG6 PF04111.12 EDK36874.2 - 5.3e-06 26.5 0.2 2e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Apg6 BARA domain LicD PF04991.13 EDK36875.2 - 1.4e-37 130.0 6.7 8.3e-36 124.2 6.7 2.2 1 1 0 1 1 1 1 LicD family MerB PF03243.15 EDK36875.2 - 0.057 13.6 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 Alkylmercury lyase Peptidase_S24 PF00717.23 EDK36876.1 - 5.1e-11 42.4 0.2 2.3e-10 40.3 0.2 2.0 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EDK36876.1 - 2.8e-05 23.9 0.0 0.0068 16.2 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 CX9C PF16860.5 EDK36877.1 - 2.8e-22 78.5 2.5 1.1e-16 60.5 0.5 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDK36877.1 - 1.9e-06 27.8 3.0 0.025 14.7 0.1 3.1 2 1 0 2 2 2 2 CHCH domain GCK PF07802.11 EDK36877.1 - 0.019 15.4 4.8 0.91 10.0 1.1 2.2 1 1 0 2 2 2 0 GCK domain COX6B PF02297.17 EDK36877.1 - 0.19 12.0 3.2 2.3 8.5 3.2 2.2 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb UPF0203 PF05254.12 EDK36877.1 - 0.25 11.6 3.0 5.8 7.2 2.5 2.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Cmc1 PF08583.10 EDK36877.1 - 0.51 10.4 4.1 0.85 9.7 2.5 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like EF-hand_1 PF00036.32 EDK36878.2 - 7.4e-06 25.1 0.0 1.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EDK36878.2 - 4.4e-05 22.8 0.1 8.8e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDK36878.2 - 0.0011 19.4 0.1 0.0021 18.5 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EDK36878.2 - 0.0012 18.7 0.1 0.0026 17.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EDK36878.2 - 0.0018 18.1 0.0 0.0092 15.8 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain HABP4_PAI-RBP1 PF04774.15 EDK36878.2 - 0.071 14.0 2.3 0.22 12.4 0.0 2.2 1 1 1 2 2 2 0 Hyaluronan / mRNA binding family NUDIX PF00293.28 EDK36879.2 - 1.8e-14 53.9 0.0 2.3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.13 EDK36880.1 - 6e-66 222.8 2.3 6.9e-66 222.6 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TPR_20 PF14561.6 EDK36880.1 - 0.018 15.4 0.6 0.049 14.0 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat LAP2alpha PF11560.8 EDK36880.1 - 0.16 11.4 1.4 0.27 10.6 1.4 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha Proteasome PF00227.26 EDK36881.2 - 1.9e-27 96.0 0.0 2.5e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit PDEase_II PF02112.15 EDK36882.2 - 1.3e-74 251.3 3.8 1.6e-74 251.0 3.8 1.0 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 EDK36882.2 - 1.4e-07 31.2 0.0 2.8e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Adap_comp_sub PF00928.21 EDK36883.2 - 1.8e-13 50.5 0.0 3e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDK36883.2 - 4.7e-09 36.3 0.1 8.2e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Shufflon_N PF04917.12 EDK36883.2 - 0.17 11.3 0.0 1.2 8.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial shufflon protein, N-terminal constant region TPR_12 PF13424.6 EDK36885.2 - 1.4e-05 25.3 10.0 0.0013 18.9 0.4 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK36885.2 - 0.013 15.3 11.5 0.094 12.6 0.0 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK36885.2 - 0.015 16.0 0.8 0.049 14.3 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2225 PF09986.9 EDK36885.2 - 0.021 14.6 0.5 0.045 13.5 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_2 PF07719.17 EDK36885.2 - 0.056 13.6 9.4 0.096 12.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDK36885.2 - 0.061 13.8 2.7 2.4 8.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RasGEF PF00617.19 EDK36885.2 - 0.076 13.2 0.1 0.3 11.3 0.0 2.0 2 1 1 3 3 3 0 RasGEF domain TPR_14 PF13428.6 EDK36885.2 - 0.087 13.7 1.7 1.5 9.8 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK36885.2 - 0.18 12.1 2.0 0.5 10.6 0.0 2.8 4 1 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDK36885.2 - 0.19 11.8 7.1 1 9.5 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EDK36885.2 - 0.21 11.7 2.0 0.37 10.9 0.3 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EDK36885.2 - 2.1 8.4 4.1 4.2 7.4 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat COG4 PF08318.12 EDK36886.2 - 9e-54 182.8 0.1 1.3e-53 182.3 0.1 1.2 1 0 0 1 1 1 1 COG4 transport protein zf_CCCH_4 PF18345.1 EDK36887.2 - 1.7e-19 69.2 37.1 1.7e-05 24.7 3.9 5.8 6 0 0 6 6 6 5 Zinc finger domain zf-CCCH PF00642.24 EDK36887.2 - 2.3e-15 56.0 30.2 0.0014 18.5 1.1 5.7 5 1 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EDK36887.2 - 3.5e-13 50.2 19.3 0.01 16.5 0.7 5.1 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.5 EDK36887.2 - 2.7e-11 43.6 12.2 1.1e-08 35.3 5.5 2.2 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 EDK36887.2 - 3.4e-10 39.5 26.4 0.0014 18.4 0.9 4.8 5 0 0 5 5 5 4 CCCH-type zinc finger AWS PF17907.1 EDK36887.2 - 0.88 9.7 14.3 3.7 7.7 0.3 4.1 4 0 0 4 4 4 0 AWS domain Spo7 PF03907.13 EDK36888.2 - 2.5e-63 213.5 4.3 3.9e-63 212.9 4.3 1.2 1 0 0 1 1 1 1 Spo7-like protein GWT1 PF06423.12 EDK36889.2 - 2.4e-35 121.9 6.4 2.4e-35 121.9 6.4 2.6 2 1 0 2 2 2 1 GWT1 Oxysterol_BP PF01237.18 EDK36890.2 - 1.6e-67 228.0 1.4 2.5e-65 220.8 1.4 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Ribosomal_L35Ae PF01247.18 EDK36891.2 - 9.3e-40 134.7 0.7 1.1e-39 134.5 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EDK36891.2 - 0.041 14.1 0.0 3.1 8.1 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain GRAB PF10375.9 EDK36892.2 - 2.6e-06 27.1 0.1 6.4e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 GRIP-related Arf-binding domain GAS PF13851.6 EDK36892.2 - 4.3e-06 26.2 59.8 0.0019 17.6 13.1 4.1 1 1 3 4 4 4 3 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 EDK36892.2 - 0.00068 19.8 7.9 0.00068 19.8 7.9 3.9 1 1 2 3 3 3 2 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EDK36892.2 - 0.00081 19.6 28.3 0.039 14.2 3.7 4.6 2 2 1 4 4 4 2 Bacterial protein of unknown function (DUF948) YabA PF06156.13 EDK36892.2 - 0.0019 18.8 10.8 0.0019 18.8 10.8 5.7 1 1 5 6 6 4 1 Initiation control protein YabA DUF2353 PF09789.9 EDK36892.2 - 0.0062 15.9 27.5 0.0062 15.9 27.5 3.4 1 1 3 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) DUF5082 PF16888.5 EDK36892.2 - 0.011 16.0 19.6 0.011 16.0 19.6 4.4 2 2 0 3 3 3 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 EDK36892.2 - 0.013 16.0 20.0 0.013 16.0 20.0 4.8 1 1 3 4 4 4 0 Apg6 coiled-coil region Fez1 PF06818.15 EDK36892.2 - 0.015 15.7 55.0 0.034 14.6 20.6 2.7 1 1 1 2 2 2 0 Fez1 DUF812 PF05667.11 EDK36892.2 - 0.023 13.6 63.1 3.5 6.4 30.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF3450 PF11932.8 EDK36892.2 - 0.085 12.1 47.6 0.1 11.9 8.0 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) EzrA PF06160.12 EDK36892.2 - 0.093 10.9 48.4 0.005 15.1 35.9 2.7 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Jnk-SapK_ap_N PF09744.9 EDK36892.2 - 0.2 11.9 59.4 0.052 13.8 21.0 4.0 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 EDK36892.2 - 0.28 11.4 68.2 0.17 12.1 18.1 4.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) MAD PF05557.13 EDK36892.2 - 0.35 9.2 59.5 0.043 12.2 31.1 2.4 1 1 2 3 3 3 0 Mitotic checkpoint protein BLOC1_2 PF10046.9 EDK36892.2 - 0.39 11.1 44.8 0.28 11.5 11.1 5.6 1 1 4 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin PF00261.20 EDK36892.2 - 0.41 10.0 60.5 1.1 8.6 3.0 3.2 2 1 1 3 3 3 0 Tropomyosin KASH_CCD PF14662.6 EDK36892.2 - 0.6 9.9 58.7 0.018 14.9 16.8 4.6 1 1 3 5 5 5 0 Coiled-coil region of CCDC155 or KASH HMMR_N PF15905.5 EDK36892.2 - 0.7 9.3 61.7 1.3 8.4 26.0 2.7 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 EDK36892.2 - 0.71 8.7 61.9 0.1 11.5 14.4 3.7 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF4407 PF14362.6 EDK36892.2 - 0.84 8.9 48.5 4.8 6.5 7.8 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 EDK36892.2 - 1.2 8.6 61.8 1.9 7.8 32.7 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 EDR1 PF14381.6 EDK36892.2 - 1.3 8.7 15.2 0.023 14.4 5.7 2.7 1 1 0 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 DUF641 PF04859.12 EDK36892.2 - 1.5 9.2 48.1 0.28 11.5 6.6 5.0 2 1 3 5 5 5 0 Plant protein of unknown function (DUF641) TPR_MLP1_2 PF07926.12 EDK36892.2 - 1.9 8.6 63.9 0.079 13.0 19.7 4.6 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 EDK36892.2 - 2 7.0 49.9 0.26 9.9 27.3 2.3 1 1 1 2 2 2 0 AAA domain SlyX PF04102.12 EDK36892.2 - 2.5 8.8 37.4 2 9.1 0.9 6.7 1 1 6 7 7 7 0 SlyX DUF1664 PF07889.12 EDK36892.2 - 2.7 8.0 41.8 0.33 11.0 7.4 4.6 2 1 4 6 6 5 0 Protein of unknown function (DUF1664) Filament PF00038.21 EDK36892.2 - 2.9 7.4 58.5 0.076 12.6 14.9 4.0 1 1 3 4 4 4 0 Intermediate filament protein MCPsignal PF00015.21 EDK36892.2 - 3.2 7.5 25.4 1.8 8.3 6.0 3.4 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4200 PF13863.6 EDK36892.2 - 3.7 8.0 59.7 1 9.8 2.3 5.5 2 1 3 5 5 4 0 Domain of unknown function (DUF4200) DUF3584 PF12128.8 EDK36892.2 - 4 4.8 54.3 0.31 8.5 27.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) CALCOCO1 PF07888.11 EDK36892.2 - 4.2 6.1 54.7 0.14 11.0 43.1 2.3 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Cep57_MT_bd PF06657.13 EDK36892.2 - 4.3 7.9 38.8 0.19 12.2 8.8 5.5 2 1 4 6 6 5 0 Centrosome microtubule-binding domain of Cep57 DUF1192 PF06698.11 EDK36892.2 - 5.5 7.1 25.8 3 8.0 3.7 5.4 4 2 1 5 5 5 0 Protein of unknown function (DUF1192) ERM PF00769.19 EDK36892.2 - 6.1 6.6 68.5 0.014 15.2 32.6 2.8 1 1 2 3 3 2 0 Ezrin/radixin/moesin family FUSC PF04632.12 EDK36892.2 - 6.5 5.2 15.8 1.6 7.2 5.5 2.2 1 1 1 2 2 2 0 Fusaric acid resistance protein family HrpB7 PF09486.10 EDK36892.2 - 7 7.0 32.0 6.6 7.1 11.6 3.8 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Pox_A_type_inc PF04508.12 EDK36892.2 - 7.6 6.6 8.7 7.6 6.6 0.4 4.3 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat TACC_C PF05010.14 EDK36892.2 - 9.4 6.0 48.9 15 5.3 31.0 3.6 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal RFC1 PF08519.12 EDK36893.2 - 2.1e-59 200.2 0.1 4.5e-59 199.1 0.1 1.6 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EDK36893.2 - 1.7e-14 54.0 0.0 6.8e-14 52.0 0.0 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EDK36893.2 - 2.1e-10 41.2 0.0 7e-10 39.4 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDK36893.2 - 7.9e-07 29.2 0.0 1.8e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EDK36893.2 - 2e-05 25.0 0.4 0.0007 20.0 0.1 3.0 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EDK36893.2 - 0.001 18.9 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDK36893.2 - 0.0056 17.0 0.0 0.03 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta PF06144.13 EDK36893.2 - 0.0082 15.9 0.0 0.024 14.4 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 EDK36893.2 - 0.011 15.8 0.0 0.5 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EDK36893.2 - 0.03 14.7 0.0 0.24 11.8 0.0 2.6 2 1 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EDK36893.2 - 0.045 14.0 0.5 0.56 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDK36893.2 - 0.046 13.9 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 EDK36893.2 - 0.051 13.9 0.0 0.22 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA C-terminal domain AAA_14 PF13173.6 EDK36893.2 - 0.051 13.6 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain PTCB-BRCT PF12738.7 EDK36893.2 - 0.083 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain AAA_11 PF13086.6 EDK36893.2 - 0.89 9.3 0.0 0.89 9.3 0.0 3.6 3 1 0 3 3 3 0 AAA domain Pkinase PF00069.25 EDK36894.2 - 3.2e-66 223.4 0.0 4.6e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36894.2 - 4.6e-35 121.2 0.0 6e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK36894.2 - 4.6e-09 36.0 0.0 1.1e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDK36894.2 - 0.00026 20.1 0.0 0.00034 19.8 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDK36894.2 - 0.00033 19.6 0.0 0.00051 18.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDK36894.2 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDK36894.2 - 0.04 12.8 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EDK36894.2 - 0.042 13.5 0.0 0.28 10.8 0.1 1.9 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDK36894.2 - 0.072 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_35 PF14516.6 EDK36894.2 - 0.1 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Nop53 PF07767.11 EDK36895.1 - 4e-28 98.9 17.1 5.5e-28 98.5 17.1 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF3573 PF12097.8 EDK36895.1 - 0.008 15.1 2.9 0.0089 14.9 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3573) Spt5_N PF11942.8 EDK36895.1 - 0.047 14.7 9.3 0.077 14.0 9.3 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Ubiquitin_2 PF14560.6 EDK36895.1 - 0.055 13.9 2.4 0.1 13.1 2.4 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain T3SS_needle_E PF08988.10 EDK36895.1 - 0.25 11.5 6.8 0.39 10.9 6.1 1.7 1 1 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle DUF974 PF06159.13 EDK36895.1 - 0.78 9.5 8.6 2.8 7.7 8.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF974) Spore_II_R PF09551.10 EDK36895.1 - 5.1 7.6 8.8 8.9 6.8 8.8 1.4 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) DUF4446 PF14584.6 EDK36895.1 - 6.9 6.6 9.8 5.1 7.1 8.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) Nop53 PF07767.11 EDK36896.1 - 1.1e-24 87.6 10.1 1.3e-24 87.3 10.1 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) S_layer_C PF05124.12 EDK36896.1 - 0.00055 20.0 4.6 0.00067 19.7 4.6 1.1 1 0 0 1 1 1 1 S-layer like family, C-terminal region POC3_POC4 PF10448.9 EDK36897.2 - 4.4e-23 81.9 0.0 5.1e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 PAC4 PF16093.5 EDK36897.2 - 2e-05 24.6 0.0 3.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Imm7 PF15585.6 EDK36897.2 - 0.16 12.3 0.0 0.53 10.6 0.0 1.8 1 1 0 2 2 2 0 Immunity protein 7 RRM_1 PF00076.22 EDK36898.2 - 2.3e-06 27.3 10.3 8.8e-05 22.3 0.2 3.4 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK36898.2 - 0.094 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nfu_N PF08712.11 EDK36900.2 - 2.7e-29 101.0 0.1 6e-29 99.9 0.1 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EDK36900.2 - 2.2e-28 98.2 0.0 3.3e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain SNF2_N PF00176.23 EDK36901.2 - 8.6e-54 182.6 0.2 1.3e-53 182.0 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK36901.2 - 2.5e-18 66.4 0.2 2.2e-15 57.0 0.1 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDK36901.2 - 3.4e-11 43.4 0.0 7.6e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RCC1_2 PF13540.6 EDK36902.2 - 2.1e-26 91.1 26.1 1.2e-09 37.7 0.5 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDK36902.2 - 5.3e-24 84.6 17.6 5.2e-06 27.0 0.6 7.0 6 2 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DUF775 PF05603.12 EDK36903.2 - 5.6e-62 208.8 0.1 6.3e-62 208.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Cys_Met_Meta_PP PF01053.20 EDK36904.2 - 2.6e-71 240.2 0.7 3.1e-71 239.9 0.7 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK36904.2 - 0.00048 19.4 0.0 0.00068 18.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK36904.2 - 0.00061 19.2 0.3 0.0025 17.2 0.1 2.0 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family SIL1 PF16782.5 EDK36905.2 - 0.00034 19.9 0.0 0.00046 19.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 SIL1 PF16782.5 EDK36906.2 - 6.1e-44 150.4 1.9 7e-44 150.2 1.9 1.0 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 DUF1839 PF08893.10 EDK36906.2 - 0.017 14.3 0.2 0.021 14.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) OmpA PF00691.20 EDK36906.2 - 0.046 14.1 0.0 0.098 13.0 0.0 1.5 1 0 0 1 1 1 0 OmpA family GSH_synth_ATP PF03917.17 EDK36907.2 - 3.6e-132 440.7 0.1 4.1e-132 440.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EDK36907.2 - 1.9e-32 111.8 1.6 4.5e-32 110.6 0.7 2.0 2 0 0 2 2 2 1 Eukaryotic glutathione synthase mRNA_decap_C PF16741.5 EDK36907.2 - 0.022 14.0 0.1 0.078 12.3 0.0 2.0 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus Peptidase_C1_2 PF03051.15 EDK36908.2 - 1.7e-160 534.6 4.4 1.9e-160 534.4 4.4 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EDK36908.2 - 7.9e-09 35.9 0.2 0.0028 17.8 0.0 2.5 2 0 0 2 2 2 2 Papain family cysteine protease Ribosomal_S8e PF01201.22 EDK36909.1 - 4.5e-57 192.0 1.5 5.5e-57 191.8 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.13 EDK36910.2 - 1.9e-21 75.5 0.3 2.3e-21 75.2 0.3 1.1 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 EDK36910.2 - 0.032 14.4 0.1 0.052 13.7 0.1 1.3 1 0 0 1 1 1 0 Zinc ribbon domain DUF1204 PF06721.11 EDK36910.2 - 0.063 12.7 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) Prok-RING_1 PF14446.6 EDK36910.2 - 0.23 11.4 2.0 0.45 10.5 2.0 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Myb_DNA-binding PF00249.31 EDK36911.2 - 5.5e-27 93.7 1.2 2.4e-14 53.2 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK36911.2 - 1e-20 73.7 0.6 5.4e-14 52.2 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EDK36911.2 - 0.037 14.1 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 SLIDE Sigma70_r4_2 PF08281.12 EDK36911.2 - 0.073 12.7 0.0 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 EDK36911.2 - 0.21 11.5 0.2 0.4 10.5 0.2 1.4 1 0 0 1 1 1 0 Homeodomain-like domain tRNA_int_endo PF01974.17 EDK36912.2 - 3.5e-16 59.0 0.0 5.3e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PNGaseA PF12222.8 EDK36913.2 - 2e-146 488.3 3.1 2e-146 488.3 3.1 1.6 2 0 0 2 2 2 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-glycanase_N PF09112.10 EDK36913.2 - 0.025 14.4 0.1 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 Peptide-N-glycosidase F, N terminal Helicase_C_4 PF13871.6 EDK36913.2 - 0.047 13.4 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue Vps35 PF03635.17 EDK36914.2 - 5.5e-246 818.6 17.7 6.8e-246 818.3 17.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RPN2_C PF18004.1 EDK36914.2 - 0.039 13.9 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nucleos_tra2_C PF07662.13 EDK36915.2 - 6e-66 222.2 2.9 1.2e-65 221.2 2.9 1.5 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EDK36915.2 - 2.8e-09 37.5 1.3 2.8e-09 37.5 1.3 3.0 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Castor_Poll_mid PF06241.12 EDK36915.2 - 0.19 11.7 0.2 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 Castor and Pollux, part of voltage-gated ion channel ATG2_CAD PF13329.6 EDK36916.2 - 1.6e-37 128.6 0.1 1.6e-37 128.6 0.1 3.3 3 0 0 3 3 3 1 Autophagy-related protein 2 CAD motif Nop14 PF04147.12 EDK36916.2 - 0.25 9.5 22.3 0.013 13.7 6.7 2.4 2 0 0 2 2 2 0 Nop14-like family Las1 PF04031.13 EDK36917.2 - 4.2e-46 156.8 0.1 1.3e-45 155.3 0.0 1.8 2 0 0 2 2 2 1 Las1-like Tli4_N PF18443.1 EDK36917.2 - 0.28 11.5 1.9 1.9 8.8 0.2 2.2 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Gpr1_Fun34_YaaH PF01184.19 EDK36918.2 - 5.3e-85 284.2 22.6 6e-85 284.0 22.6 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Urate_ox_N PF06181.11 EDK36918.2 - 0.0071 15.7 1.7 0.011 15.0 1.7 1.3 1 0 0 1 1 1 1 Urate oxidase N-terminal CobD_Cbib PF03186.13 EDK36918.2 - 0.094 11.9 5.0 0.11 11.7 0.0 2.6 2 1 1 3 3 3 0 CobD/Cbib protein DUF4395 PF14340.6 EDK36918.2 - 4.6 7.6 24.2 0.84 10.0 6.9 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4395) Mg_trans_NIPA PF05653.14 EDK36919.2 - 3e-10 39.7 11.7 1.8e-06 27.3 3.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EDK36919.2 - 1e-05 25.7 5.5 1e-05 25.7 5.5 3.4 2 1 1 3 3 3 1 EamA-like transporter family Bap31 PF05529.12 EDK36919.2 - 0.012 15.4 0.6 0.77 9.6 0.0 2.7 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region CheX PF13690.6 EDK36919.2 - 0.071 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX RAMP4 PF06624.12 EDK36919.2 - 0.13 12.3 0.0 0.13 12.3 0.0 2.3 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 CDC14 PF08045.11 EDK36920.2 - 2.2e-39 135.3 1.8 5.6e-38 130.7 1.9 2.2 1 1 2 3 3 3 2 Cell division control protein 14, SIN component DUF913 PF06025.12 EDK36920.2 - 0.054 12.5 0.4 3 6.7 0.1 2.6 2 1 1 3 3 3 0 Domain of Unknown Function (DUF913) MDM10 PF12519.8 EDK36921.2 - 1.3e-124 416.6 7.6 1.5e-124 416.4 7.6 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 DUF2011 PF09428.10 EDK36921.2 - 0.013 15.7 0.2 0.025 14.8 0.2 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Mit_ribos_Mrp51 PF11709.8 EDK36922.2 - 1.6e-59 202.4 5.7 2.4e-57 195.2 5.7 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Caf4 PF11615.8 EDK36923.2 - 0.017 15.0 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 CCR4-associated factor 4 BUD22 PF09073.10 EDK36923.2 - 3.1 7.1 56.1 0.092 12.1 33.5 2.3 2 0 0 2 2 2 0 BUD22 V_ATPase_I PF01496.19 EDK36923.2 - 7.1 4.4 12.0 14 3.5 12.0 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.25 EDK36924.2 - 5.8e-63 212.7 0.0 8.8e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK36924.2 - 2.3e-47 161.5 0.0 3.5e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK36924.2 - 6.3e-06 25.2 2.2 1.6e-05 23.9 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase Haspin_kinase PF12330.8 EDK36924.2 - 0.00012 21.2 0.2 0.0049 15.9 0.0 2.5 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EDK36924.2 - 0.00015 21.2 0.2 0.00092 18.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDK36924.2 - 0.0042 17.0 1.4 0.011 15.6 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDK36924.2 - 0.073 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDK36924.2 - 0.1 12.2 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 RIO1 family IGPD PF00475.18 EDK36925.1 - 3.6e-58 196.0 1.9 5.2e-58 195.4 1.9 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase SpoU_methylase PF00588.19 EDK36926.2 - 1.2e-22 80.6 0.0 2.7e-22 79.5 0.0 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EDK36926.2 - 6.8e-15 55.1 0.0 2.4e-14 53.3 0.0 2.0 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding DUF676 PF05057.14 EDK36927.2 - 1.8e-39 135.5 0.0 3.8e-39 134.4 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EDK36927.2 - 3.4e-09 36.9 0.0 7.6e-09 35.8 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EDK36927.2 - 0.00052 19.8 0.1 0.0042 16.8 0.1 2.2 1 1 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EDK36927.2 - 0.012 15.5 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) API5 PF05918.11 EDK36927.2 - 0.017 13.9 0.1 0.025 13.4 0.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Lipase_2 PF01674.18 EDK36927.2 - 0.034 13.7 0.6 0.096 12.2 0.6 1.7 1 1 0 1 1 1 0 Lipase (class 2) Ysc84 PF04366.12 EDK36928.1 - 1.9e-29 102.0 0.1 3.2e-29 101.3 0.1 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EDK36928.1 - 1.1e-15 56.9 0.1 1.9e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDK36928.1 - 2.6e-13 49.4 0.0 5.7e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDK36928.1 - 1.3e-11 44.2 0.0 2.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Arm PF00514.23 EDK36929.2 - 1.8e-76 250.1 30.3 9.5e-12 44.5 0.1 11.2 11 1 1 12 12 12 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDK36929.2 - 5.8e-22 77.8 13.8 0.00032 21.1 0.1 8.4 7 1 1 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 EDK36929.2 - 8.2e-17 61.4 8.2 0.00096 19.5 0.1 7.0 3 2 5 8 8 8 5 HEAT repeats HEAT PF02985.22 EDK36929.2 - 1.6e-13 49.6 20.5 0.036 14.3 0.1 9.1 10 0 0 10 10 8 4 HEAT repeat Adaptin_N PF01602.20 EDK36929.2 - 5.6e-13 48.3 4.7 6.2e-08 31.7 1.4 2.1 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.12 EDK36929.2 - 8.1e-10 37.5 0.5 6.2e-09 34.6 0.3 2.7 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) Arm_2 PF04826.13 EDK36929.2 - 6.4e-08 32.4 8.7 3.5e-05 23.4 3.7 3.4 2 1 2 4 4 4 3 Armadillo-like V-ATPase_H_C PF11698.8 EDK36929.2 - 2.2e-05 24.5 2.9 0.15 12.2 0.0 4.8 3 1 4 7 7 7 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EDK36929.2 - 4.9e-05 22.8 8.6 0.027 13.8 0.4 3.9 1 1 1 3 3 3 3 V-ATPase subunit H Cnd1 PF12717.7 EDK36929.2 - 7e-05 22.9 9.1 0.044 13.8 0.3 4.5 1 1 5 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDK36929.2 - 8.7e-05 23.0 0.1 0.76 10.4 0.0 3.1 2 1 0 2 2 2 2 Vacuolar 14 Fab1-binding region DUF5578 PF17741.1 EDK36929.2 - 0.00014 21.4 3.8 0.32 10.4 0.0 4.0 1 1 2 3 3 3 2 Family of unknown function (DUF5578) DUF3361 PF11841.8 EDK36929.2 - 0.00083 19.3 10.4 0.014 15.4 0.1 4.6 2 1 3 5 5 5 1 Domain of unknown function (DUF3361) Tti2 PF10521.9 EDK36929.2 - 0.013 15.0 0.0 0.24 10.9 0.0 2.5 2 0 0 2 2 2 0 Tti2 family RICTOR_N PF14664.6 EDK36929.2 - 0.076 12.0 10.9 0.055 12.5 1.0 3.7 1 1 2 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term DUF3110 PF11360.8 EDK36929.2 - 0.11 12.7 0.0 6.5 7.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3110) CTNNBL PF08216.11 EDK36929.2 - 0.23 11.6 2.1 9.3 6.5 0.0 4.2 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear Snf7 PF03357.21 EDK36930.2 - 2.1e-18 66.5 22.2 3.6e-18 65.8 22.2 1.3 1 0 0 1 1 1 1 Snf7 SecA_DEAD PF07517.14 EDK36930.2 - 2.6 7.3 8.9 2.3 7.4 1.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain Allexi_40kDa PF05549.11 EDK36930.2 - 4.8 6.6 20.9 1.3 8.5 3.8 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein CRR7 PF12095.8 EDK36930.2 - 6.8 7.2 11.9 14 6.2 0.4 3.3 1 1 2 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 ParA PF10609.9 EDK36931.2 - 1.8e-92 309.3 0.0 2.1e-92 309.0 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDK36931.2 - 9e-11 41.9 0.0 2.2e-10 40.7 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDK36931.2 - 3.3e-05 23.9 0.0 0.00041 20.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 EDK36931.2 - 6.5e-05 22.3 0.0 0.00011 21.6 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EDK36931.2 - 0.00065 19.0 0.2 0.0045 16.2 0.1 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 EDK36931.2 - 0.0097 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_26 PF13500.6 EDK36931.2 - 0.013 15.3 0.0 0.091 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDK36931.2 - 0.03 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain CBP_BcsQ PF06564.12 EDK36931.2 - 0.042 13.3 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 EDK36931.2 - 0.092 12.2 0.0 0.65 9.4 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.15 EDK36931.2 - 0.098 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain TF_Zn_Ribbon PF08271.12 EDK36931.2 - 0.1 12.1 0.3 0.22 11.0 0.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Nucleoporin2 PF04096.14 EDK36932.2 - 1.3e-43 148.7 0.0 2.9e-43 147.5 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 EDK36932.2 - 9.5e-30 103.7 0.5 1.2e-15 57.4 0.0 2.3 1 1 1 2 2 2 2 Nuclear protein 96 YjeF_N PF03853.15 EDK36933.2 - 1.2e-37 129.5 0.0 1.6e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EDK36933.2 - 1.1e-07 32.7 2.1 3.7e-07 31.0 2.1 2.0 1 1 0 1 1 1 1 FDF domain ROF PF07073.12 EDK36933.2 - 0.14 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) MFS_1 PF07690.16 EDK36934.2 - 1.6e-27 96.4 56.2 4.7e-23 81.7 41.5 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily UBX PF00789.20 EDK36935.2 - 5.7e-11 42.5 0.0 1.9e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 UBX domain PALP PF00291.25 EDK36937.2 - 2.6e-67 227.3 0.0 3.3e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EDK36937.2 - 2.4e-12 47.1 0.0 1.7e-08 34.7 0.0 2.6 2 0 0 2 2 2 2 CBS domain Zeta_toxin PF06414.12 EDK36937.2 - 0.051 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin TFIIS_M PF07500.14 EDK36938.2 - 4.2e-30 104.5 1.0 5.9e-30 104.0 1.0 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EDK36938.2 - 5.9e-19 67.6 6.3 2.7e-18 65.5 7.5 1.5 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 EDK36938.2 - 0.047 13.4 1.4 0.079 12.7 1.4 1.3 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Elf1 PF05129.13 EDK36938.2 - 0.061 13.4 2.9 0.11 12.6 2.9 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like HypA PF01155.19 EDK36938.2 - 0.25 11.4 1.3 0.46 10.5 1.3 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-DNL PF05180.12 EDK36938.2 - 0.64 10.0 3.9 1.8 8.5 3.6 1.8 2 0 0 2 2 2 0 DNL zinc finger CSTF2_hinge PF14327.6 EDK36939.1 - 1.6e-18 66.9 3.2 2.8e-18 66.1 3.2 1.4 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EDK36939.1 - 7.4e-16 57.7 0.0 1.3e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EDK36939.1 - 0.0021 17.6 0.0 0.0075 15.8 0.0 2.0 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal AnfO_nitrog PF09582.10 EDK36939.1 - 0.047 13.0 0.1 0.087 12.2 0.1 1.4 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) RRM_occluded PF16842.5 EDK36939.1 - 0.11 12.3 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif FlgN PF05130.12 EDK36939.1 - 0.49 10.9 6.1 3.1 8.3 2.5 2.4 1 1 1 2 2 2 0 FlgN protein CSTF2_hinge PF14327.6 EDK36940.2 - 2.8e-21 75.7 2.1 3.3e-21 75.5 0.1 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 EDK36940.2 - 1.6e-10 40.4 2.8 5.8e-10 38.6 2.8 2.1 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 EDK36940.2 - 4.6e-10 39.2 0.0 1.1e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EDK36941.2 - 9.1e-10 38.7 10.1 2.5e-08 34.1 1.3 3.1 3 0 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 EDK36941.2 - 1.1e-09 38.5 6.2 7.6e-09 35.7 0.9 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDK36941.2 - 3.3e-07 30.0 6.3 1.1e-05 25.2 1.8 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK36941.2 - 3.6e-06 26.9 10.7 0.00014 21.9 0.2 3.3 3 0 0 3 3 3 2 RING-type zinc-finger Prok-RING_4 PF14447.6 EDK36941.2 - 1.8e-05 24.5 0.7 1.8e-05 24.5 0.7 2.8 3 1 0 3 3 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDK36941.2 - 4e-05 23.4 0.9 4e-05 23.4 0.9 3.1 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDK36941.2 - 0.0001 22.3 1.1 0.00046 20.2 0.3 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 EDK36941.2 - 0.00078 19.2 0.8 0.00078 19.2 0.8 2.7 3 0 0 3 3 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 EDK36941.2 - 0.0019 18.0 7.0 0.0067 16.3 0.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK36941.2 - 0.0019 18.1 0.7 0.0019 18.1 0.7 2.7 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 EDK36941.2 - 0.0022 17.8 0.4 0.023 14.5 0.1 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein FANCL_C PF11793.8 EDK36941.2 - 0.042 14.0 4.2 3.1 8.0 1.0 3.2 2 1 0 2 2 2 0 FANCL C-terminal domain zf-Di19 PF05605.12 EDK36941.2 - 0.23 11.8 1.3 21 5.5 0.0 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 EDK36941.2 - 0.28 11.7 7.3 0.22 12.0 1.7 2.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-piccolo PF05715.13 EDK36941.2 - 0.4 10.9 3.5 8.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Piccolo Zn-finger zf-RING_11 PF17123.5 EDK36941.2 - 0.84 9.4 12.2 1.6 8.6 0.2 3.6 4 0 0 4 4 4 0 RING-like zinc finger zf-RING_4 PF14570.6 EDK36941.2 - 0.91 9.4 3.5 2.3 8.1 0.3 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain YacG PF03884.14 EDK36941.2 - 1 9.2 8.2 1.7 8.5 0.1 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-C3HC4_4 PF15227.6 EDK36941.2 - 1.4 9.1 12.4 0.11 12.7 2.0 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING DUF2225 PF09986.9 EDK36941.2 - 2.3 7.9 5.6 9 6.0 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) CENP-X PF09415.10 EDK36942.2 - 0.22 11.9 1.2 0.45 10.9 1.2 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Fungal_trans PF04082.18 EDK36943.2 - 1.4e-70 237.4 8.3 1.4e-70 237.4 8.3 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDK36943.2 - 1.7e-05 25.0 2.6 1.7e-05 25.0 2.6 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK36943.2 - 0.0054 17.5 15.1 0.0079 16.9 1.4 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger Ribosomal_S8e PF01201.22 EDK36944.2 - 1.2e-44 151.8 0.0 1.7e-44 151.3 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3746 PF12562.8 EDK36944.2 - 0.11 12.5 0.2 0.28 11.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) HPD PF05044.12 EDK36944.2 - 0.22 11.4 2.2 0.34 10.8 0.3 2.0 2 0 0 2 2 2 0 Homeo-prospero domain Sas10_Utp3 PF04000.15 EDK36945.2 - 2.1e-12 47.5 0.4 2.1e-12 47.5 0.4 2.4 2 0 0 2 2 2 1 Sas10/Utp3/C1D family XPC-binding PF09280.11 EDK36945.2 - 0.012 15.4 0.1 0.03 14.1 0.1 1.7 1 0 0 1 1 1 0 XPC-binding domain NHR2 PF08788.11 EDK36945.2 - 0.017 14.9 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 NHR2 domain like FliP PF00813.20 EDK36945.2 - 0.52 10.2 1.7 0.94 9.3 0.0 2.0 2 0 0 2 2 2 0 FliP family PUF PF00806.19 EDK36946.2 - 1.4e-57 188.2 24.4 1.3e-07 30.9 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat PriX PF18689.1 EDK36946.2 - 0.011 16.0 3.1 1.1 9.6 0.1 2.9 3 0 0 3 3 3 0 Primase X Mistic PF11458.8 EDK36946.2 - 0.12 12.4 1.7 24 5.0 0.0 3.6 4 0 0 4 4 4 0 Membrane-integrating protein Mistic DUF374 PF04028.13 EDK36946.2 - 0.13 11.8 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF374) Fungal_TACC PF12709.7 EDK36947.2 - 0.0025 18.2 7.5 0.0025 18.2 7.5 3.1 1 1 2 3 3 3 1 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_1 PF00170.21 EDK36947.2 - 0.019 15.1 4.9 0.019 15.1 4.9 3.1 2 1 1 3 3 3 0 bZIP transcription factor DUF1640 PF07798.11 EDK36947.2 - 0.06 13.4 17.1 0.1 12.6 17.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) TSC22 PF01166.18 EDK36947.2 - 0.27 11.6 7.7 0.48 10.8 2.4 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Caldesmon PF02029.15 EDK36947.2 - 0.53 9.0 20.4 1 8.0 20.4 1.4 1 0 0 1 1 1 0 Caldesmon NYD-SP28_assoc PF14775.6 EDK36947.2 - 0.54 10.4 10.2 6.2 7.0 2.5 3.5 3 0 0 3 3 3 0 Sperm tail C-terminal domain Cnn_1N PF07989.11 EDK36947.2 - 0.54 10.4 17.9 0.049 13.8 12.0 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Shugoshin_N PF07558.11 EDK36947.2 - 1.1 9.2 8.0 0.44 10.5 3.6 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF2381 PF09544.10 EDK36947.2 - 1.4 8.3 6.6 0.49 9.9 3.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2381) bZIP_2 PF07716.15 EDK36947.2 - 1.7 8.8 17.8 0.27 11.4 5.3 3.3 3 0 0 3 3 3 0 Basic region leucine zipper YabA PF06156.13 EDK36947.2 - 1.9 9.1 14.5 1.6 9.4 8.7 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Remorin_C PF03763.13 EDK36947.2 - 3.1 7.7 14.7 1.1 9.2 10.6 2.2 1 1 1 2 2 2 0 Remorin, C-terminal region APC_N_CC PF16689.5 EDK36947.2 - 4.8 7.3 9.7 3.2 7.9 3.5 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Prominin PF05478.11 EDK36947.2 - 8.9 4.1 6.3 12 3.7 6.3 1.1 1 0 0 1 1 1 0 Prominin V_ATPase_I PF01496.19 EDK36947.2 - 9.4 4.0 11.7 14 3.4 11.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nucleoporin_FG PF13634.6 EDK36948.2 - 2.8e-27 95.4 152.3 1.7e-10 41.6 38.5 5.1 1 1 4 5 5 5 5 Nucleoporin FG repeat region BLOC1_2 PF10046.9 EDK36948.2 - 0.05 13.9 5.2 6.8 7.1 0.8 3.4 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LOH1CR12 PF10158.9 EDK36948.2 - 0.25 11.4 4.9 0.93 9.5 1.0 2.5 1 1 2 3 3 3 0 Tumour suppressor protein DUF16 PF01519.16 EDK36948.2 - 0.35 11.4 4.9 4.4 7.8 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 DASH_Dad2 PF08654.10 EDK36948.2 - 0.42 11.1 3.1 2.9 8.4 0.2 2.6 1 1 1 2 2 2 0 DASH complex subunit Dad2 Lipoprotein_20 PF13942.6 EDK36948.2 - 0.72 9.7 3.2 1.2 9.1 3.2 1.2 1 0 0 1 1 1 0 YfhG lipoprotein Occludin_ELL PF07303.13 EDK36948.2 - 0.95 10.2 5.2 12 6.7 0.5 3.1 2 1 0 3 3 3 0 Occludin homology domain NleF_casp_inhib PF16809.5 EDK36948.2 - 3.4 7.6 5.8 4.4 7.2 0.4 2.9 2 1 1 3 3 3 0 NleF caspase inhibitor Fib_alpha PF08702.10 EDK36948.2 - 8.6 6.5 10.4 23 5.1 2.0 2.9 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Bud13 PF09736.9 EDK36949.2 - 4.9e-38 130.8 3.7 4.9e-38 130.8 3.7 1.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex TERB2 PF15101.6 EDK36949.2 - 0.24 11.4 2.9 0.42 10.7 2.9 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CALM_bind PF16025.5 EDK36949.2 - 1.5 9.4 7.1 4.2 7.9 7.1 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Mito_carr PF00153.27 EDK36951.1 - 8.8e-72 237.1 1.3 6.5e-26 90.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_6 PF13405.6 EDK36951.1 - 0.019 14.9 0.1 18 5.6 0.0 4.8 6 0 0 6 6 6 0 EF-hand domain Serine_protease PF18405.1 EDK36951.1 - 0.05 12.7 0.1 0.78 8.8 0.0 2.5 2 1 0 2 2 2 0 Gammaproteobacterial serine protease CRAL_TRIO_2 PF13716.6 EDK36951.1 - 0.091 12.9 1.6 10 6.3 0.0 2.8 2 1 1 3 3 3 0 Divergent CRAL/TRIO domain XRN_M PF17846.1 EDK36952.2 - 1.5e-89 301.0 8.3 7.8e-89 298.6 8.3 1.9 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EDK36952.2 - 1.9e-78 263.2 0.1 3.2e-78 262.5 0.1 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EDK36952.2 - 2.7e-61 206.7 0.2 8.4e-61 205.1 0.1 1.9 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain Xrn1_D3 PF18194.1 EDK36952.2 - 6.6e-30 103.0 0.1 2.4e-29 101.3 0.1 2.1 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 XRN1_D2_D3 PF18334.1 EDK36952.2 - 7.3e-29 99.8 0.0 2e-28 98.4 0.0 1.8 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EDK36952.2 - 2.2e-15 56.5 0.7 4.3e-15 55.6 0.7 1.5 1 0 0 1 1 1 1 Xrn1 SH3-like domain zf-C2H2 PF00096.26 EDK36954.2 - 1.9e-09 37.4 19.3 0.0016 18.7 0.2 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK36954.2 - 9.3e-06 25.8 0.6 9.3e-06 25.8 0.6 4.5 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK36954.2 - 0.00019 22.0 26.2 0.022 15.5 0.1 4.1 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK36954.2 - 0.00031 20.6 12.5 0.027 14.5 0.0 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK36954.2 - 0.00075 19.7 6.1 0.84 10.0 0.5 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 EDK36954.2 - 0.0076 16.1 0.4 0.0076 16.1 0.4 2.5 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-RRPl_C4 PF17026.5 EDK36954.2 - 0.013 15.5 4.5 0.036 14.2 4.5 1.7 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type C1_4 PF07975.12 EDK36954.2 - 0.014 15.6 4.1 2.6 8.4 0.8 2.8 2 0 0 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 EDK36954.2 - 0.056 13.6 4.9 0.079 13.1 0.8 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf_UBZ PF18439.1 EDK36954.2 - 0.27 10.9 5.5 3.7 7.2 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger FYVE_2 PF02318.16 EDK36954.2 - 0.31 11.3 3.6 0.71 10.1 3.6 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger zf-met PF12874.7 EDK36954.2 - 0.36 11.3 14.4 4 8.0 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DZR PF12773.7 EDK36954.2 - 0.58 10.2 6.2 16 5.6 5.9 2.4 1 1 1 2 2 2 0 Double zinc ribbon zf-C4_ClpX PF06689.13 EDK36954.2 - 1 9.3 2.9 5 7.1 0.0 2.6 2 1 0 2 2 2 0 ClpX C4-type zinc finger zf-HIT PF04438.16 EDK36954.2 - 5.1 7.1 8.1 39 4.2 0.4 3.3 3 0 0 3 3 3 0 HIT zinc finger Pan3_PK PF18101.1 EDK36955.2 - 3.3e-48 163.2 1.2 4.5e-48 162.7 0.2 1.7 2 0 0 2 2 2 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EDK36955.2 - 1e-06 28.3 0.0 2.8e-06 26.9 0.0 1.6 1 1 1 2 2 2 1 Protein kinase domain PRCC PF10253.9 EDK36955.2 - 4.6 8.0 9.9 0.15 12.8 3.7 1.6 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Response_reg PF00072.24 EDK36956.2 - 6.7e-20 71.3 0.0 2.5e-14 53.4 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain PRCC PF10253.9 EDK36956.2 - 8 7.2 21.4 0.11 13.2 2.8 2.8 2 1 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Asp_protease PF09668.10 EDK36957.2 - 9.6e-47 157.8 0.1 1.4e-46 157.3 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EDK36957.2 - 1.6e-18 67.0 0.0 4.1e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDK36957.2 - 3.5e-11 43.6 0.1 1.1e-10 42.0 0.1 1.9 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.23 EDK36957.2 - 2.8e-10 39.8 0.4 6e-10 38.7 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EDK36957.2 - 1.5e-09 37.5 0.0 3.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.20 EDK36957.2 - 4.8e-07 30.0 0.1 2.3e-06 27.8 0.1 2.2 1 1 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 EDK36957.2 - 4.8e-05 23.1 0.2 0.00012 21.8 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EDK36957.2 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain Ubiquitin_5 PF18037.1 EDK36957.2 - 0.046 14.1 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain TBK1_ULD PF18396.1 EDK36957.2 - 0.087 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Aldo_ket_red PF00248.21 EDK36958.1 - 4.5e-42 144.2 0.0 7.1e-42 143.6 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family GDI PF00996.18 EDK36959.2 - 9.3e-142 472.6 0.2 1e-141 472.4 0.2 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EDK36959.2 - 0.039 14.2 0.0 0.096 12.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_M24 PF00557.24 EDK36960.2 - 1.7e-56 191.2 0.0 3e-56 190.4 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDK36960.2 - 1.1e-18 67.1 0.0 2.4e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain PBS_linker_poly PF00427.21 EDK36960.2 - 0.016 15.3 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide JAB PF01398.21 EDK36961.2 - 4.8e-33 113.6 0.2 4.8e-33 113.6 0.2 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDK36961.2 - 8.3e-14 52.0 1.0 1.7e-13 51.0 1.0 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EDK36961.2 - 5.7e-08 32.6 0.0 9e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 EDK36961.2 - 0.034 14.2 0.3 0.073 13.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) LamB PF02264.15 EDK36961.2 - 0.11 12.4 0.9 0.18 11.7 0.9 1.5 1 1 0 1 1 1 0 LamB porin UCH PF00443.29 EDK36962.2 - 1.4e-17 64.0 1.1 2.9e-17 63.0 0.5 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDK36962.2 - 3.2e-11 43.4 2.4 3.2e-11 43.4 2.4 2.3 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein SAM35 PF10806.8 EDK36963.2 - 8.8e-32 110.0 0.0 5.8e-31 107.4 0.0 2.1 2 0 0 2 2 2 1 SAM35, subunit of SAM coomplex Acetyltransf_10 PF13673.7 EDK36964.1 - 1.5e-14 54.0 0.0 2.1e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDK36964.1 - 4.2e-13 49.6 0.0 7.1e-13 48.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK36964.1 - 1e-06 29.1 0.0 1.5e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK36964.1 - 0.022 14.7 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 EDK36964.1 - 0.087 12.9 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CAF1C_H4-bd PF12265.8 EDK36965.2 - 1.5e-22 79.6 0.4 3.4e-22 78.5 0.4 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDK36965.2 - 5.2e-12 46.1 12.1 0.00091 20.0 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat BING4CT PF08149.11 EDK36965.2 - 0.03 14.1 0.0 13 5.7 0.0 3.4 3 0 0 3 3 3 0 BING4CT (NUC141) domain Sulfate_transp PF00916.20 EDK36966.2 - 3.8e-79 266.2 14.6 5e-79 265.8 14.6 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDK36966.2 - 5.3e-16 58.3 0.0 3.4e-15 55.7 0.0 2.2 2 0 0 2 2 2 1 STAS domain DUF1427 PF07235.11 EDK36966.2 - 0.038 13.9 0.3 0.26 11.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1427) ETF PF01012.21 EDK36967.1 - 7.4e-41 140.0 0.9 1.2e-40 139.4 0.9 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EDK36967.1 - 5.3e-35 119.3 0.1 1.2e-34 118.1 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain TPP_enzyme_M PF00205.22 EDK36967.1 - 0.0059 16.3 0.3 0.018 14.8 0.3 1.8 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TniB PF05621.11 EDK36968.2 - 0.068 12.6 0.5 0.18 11.2 0.1 1.9 2 0 0 2 2 2 0 Bacterial TniB protein DUF1631 PF07793.11 EDK36968.2 - 6.2 5.1 10.6 6.6 5.0 10.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Fungal_trans PF04082.18 EDK36969.2 - 3.8e-12 45.8 0.2 6.8e-12 45.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK36969.2 - 1.2e-05 25.3 8.4 2.1e-05 24.6 8.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LRR_8 PF13855.6 EDK36970.2 - 2.5e-27 94.4 25.9 2.3e-13 49.7 2.9 6.5 4 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EDK36970.2 - 6.7e-22 77.2 33.6 3.7e-07 30.4 3.9 7.8 2 2 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK36970.2 - 2.5e-12 45.8 23.2 0.05 13.7 1.0 10.4 12 1 0 12 12 12 5 Leucine Rich repeat LRR_9 PF14580.6 EDK36970.2 - 5.3e-09 35.8 10.0 0.081 12.4 0.3 4.2 1 1 1 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EDK36970.2 - 0.0001 22.4 26.2 1.8 9.4 0.2 8.7 5 4 0 5 5 5 2 Leucine Rich Repeat FNIP PF05725.12 EDK36970.2 - 0.0086 16.2 14.8 0.071 13.3 1.3 4.8 4 1 2 6 6 6 4 FNIP Repeat F-box-like PF12937.7 EDK36970.2 - 0.16 11.9 0.0 0.44 10.5 0.0 1.8 1 0 0 1 1 1 0 F-box-like CAP PF00188.26 EDK36971.2 - 1e-16 61.9 3.5 1e-16 61.9 3.5 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Phage_TTP_11 PF16460.5 EDK36971.2 - 0.038 13.8 0.3 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Phage tail tube, TTP, lambda-like AAA_11 PF13086.6 EDK36972.2 - 3.3e-58 197.5 0.1 7e-58 196.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EDK36972.2 - 5e-58 196.0 0.0 1.4e-57 194.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK36972.2 - 5e-10 39.9 0.0 1.6e-08 35.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK36972.2 - 1.8e-09 37.6 0.0 9.1e-08 32.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EDK36972.2 - 8e-07 29.2 0.2 3.4e-06 27.2 0.2 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EDK36972.2 - 1.2e-06 28.5 0.0 1.3 8.7 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EDK36972.2 - 4.5e-06 26.3 0.0 0.0024 17.4 0.0 3.1 3 0 0 3 3 3 1 PhoH-like protein AAA_22 PF13401.6 EDK36972.2 - 7.6e-06 26.2 0.3 7.9e-05 23.0 0.2 2.8 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDK36972.2 - 0.00015 21.6 0.0 0.00043 20.2 0.0 1.8 1 0 0 1 1 1 1 Helicase PIF1 PF05970.14 EDK36972.2 - 0.0013 17.9 0.0 0.56 9.3 0.0 2.4 2 0 0 2 2 2 2 PIF1-like helicase AAA_16 PF13191.6 EDK36972.2 - 0.0015 18.9 0.0 0.0037 17.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EDK36972.2 - 0.0038 16.5 0.1 0.013 14.8 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 EDK36972.2 - 0.0069 16.6 0.0 0.017 15.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDK36972.2 - 0.0075 16.8 0.2 0.044 14.3 0.2 2.4 1 1 0 1 1 1 1 ABC transporter UvrD-helicase PF00580.21 EDK36972.2 - 0.0075 15.8 0.7 0.018 14.6 0.7 1.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA PF00004.29 EDK36972.2 - 0.0085 16.5 0.0 0.027 14.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EDK36972.2 - 0.014 15.3 0.3 0.032 14.1 0.3 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EDK36972.2 - 0.022 14.8 0.0 0.065 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDK36972.2 - 0.024 14.3 0.0 0.15 11.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EDK36972.2 - 0.049 13.7 0.0 0.46 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Herpes_ori_bp PF02399.15 EDK36972.2 - 0.063 11.3 0.0 0.096 10.7 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein AAA_23 PF13476.6 EDK36972.2 - 0.11 13.0 15.2 3.1 8.2 15.1 2.9 1 1 0 1 1 1 0 AAA domain Fip1 PF05182.13 EDK36973.1 - 1.6e-22 78.7 1.0 1.6e-22 78.7 1.0 1.8 2 0 0 2 2 2 1 Fip1 motif Menin PF05053.13 EDK36973.1 - 3.2 6.0 6.3 4.2 5.6 6.3 1.0 1 0 0 1 1 1 0 Menin PH PF00169.29 EDK36974.2 - 2.7e-11 43.9 0.1 1.2e-10 41.8 0.1 2.2 1 0 0 1 1 1 1 PH domain Recep_L_domain PF01030.24 EDK36975.1 - 1e-07 32.1 11.4 0.0082 16.2 0.4 4.7 1 1 3 5 5 5 3 Receptor L domain Ima1_N PF09779.9 EDK36975.1 - 0.13 13.1 2.2 0.25 12.2 2.2 1.4 1 0 0 1 1 1 0 Ima1 N-terminal domain LRR_9 PF14580.6 EDK36975.1 - 0.34 10.4 6.0 0.13 11.7 0.9 2.7 2 1 1 3 3 3 0 Leucine-rich repeat Macoilin PF09726.9 EDK36975.1 - 0.41 9.1 8.9 0.68 8.4 8.9 1.3 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 EDK36975.1 - 0.41 10.2 24.2 0.64 9.6 24.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SecG PF03840.14 EDK36975.1 - 0.47 10.6 4.3 1.4 9.0 4.3 1.9 1 0 0 1 1 1 0 Preprotein translocase SecG subunit AF-4 PF05110.13 EDK36975.1 - 1.2 7.2 22.3 1.8 6.6 22.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4692 PF15763.5 EDK36975.1 - 1.7 9.1 6.7 3.4 8.1 6.7 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) UDPGP PF01704.18 EDK36976.2 - 1.8e-45 155.3 0.0 2.4e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase FGGY_C PF02782.16 EDK36977.2 - 5e-69 232.0 0.3 1.5e-68 230.5 0.2 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDK36977.2 - 7.3e-54 182.9 0.4 6.4e-46 156.9 0.1 3.1 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain adh_short PF00106.25 EDK36978.1 - 3.1e-17 62.7 0.0 4.1e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK36978.1 - 3e-16 59.7 0.0 4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK36978.1 - 5.4e-06 26.4 0.0 7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK36978.1 - 5.8e-05 23.0 0.1 7.8e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding PRMT5 PF05185.16 EDK36978.1 - 0.012 15.4 0.1 0.019 14.8 0.1 1.3 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase TrkA_N PF02254.18 EDK36978.1 - 0.076 13.3 0.2 0.32 11.3 0.2 1.9 1 1 0 1 1 1 0 TrkA-N domain adh_short PF00106.25 EDK36979.2 - 2.8e-08 33.5 0.0 4.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK36979.2 - 3e-07 30.2 0.0 3.4e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF3458 PF11940.8 EDK36981.1 - 0.07 13.6 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Ig-like fold MtrB PF05440.12 EDK36983.2 - 0.0098 16.3 0.0 0.081 13.3 0.1 2.4 2 0 0 2 2 2 1 Tetrahydromethanopterin S-methyltransferase subunit B DUF948 PF06103.11 EDK36983.2 - 0.049 13.9 2.7 36 4.7 1.2 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) CHASE3 PF05227.13 EDK36983.2 - 0.11 12.4 6.1 0.033 14.1 1.2 2.4 2 1 0 2 2 2 0 CHASE3 domain DUF5302 PF17227.2 EDK36983.2 - 0.16 13.0 3.5 0.65 11.0 3.5 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5302) Prominin PF05478.11 EDK36983.2 - 0.29 9.0 8.3 0.082 10.9 4.6 1.8 2 0 0 2 2 2 0 Prominin Baculo_PEP_C PF04513.12 EDK36983.2 - 0.3 11.1 2.4 11 6.0 0.1 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4735 PF15882.5 EDK36983.2 - 0.42 10.0 7.4 4.2 6.7 0.2 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4735) DUF4665 PF15679.5 EDK36983.2 - 3.3 8.4 11.7 0.48 11.1 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4665) AA_permease PF00324.21 EDK36984.2 - 4.4e-72 243.2 47.9 5.2e-72 243.0 47.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK36984.2 - 1.6e-20 73.4 53.1 4.4e-20 71.9 53.1 1.6 1 1 0 1 1 1 1 Amino acid permease Gln-synt_C PF00120.24 EDK36985.1 - 1.7e-18 66.7 0.0 1.1e-17 64.1 0.0 1.9 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EDK36985.1 - 1.2e-13 50.6 0.0 1.9e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.14 EDK36986.2 - 5.2e-45 154.1 3.6 5.2e-45 154.1 3.6 1.7 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EDK36986.2 - 4e-28 97.9 3.4 6e-28 97.3 0.2 2.7 3 0 0 3 3 3 1 V-ATPase subunit H BIR PF00653.21 EDK36987.2 - 6.6e-37 126.0 9.5 3e-20 72.7 1.6 2.9 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain SAPS PF04499.15 EDK36988.2 - 2.5e-158 527.9 0.1 2.5e-158 527.9 0.1 2.3 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein DnaJ PF00226.31 EDK36989.2 - 2e-14 53.4 0.0 5.3e-14 52.1 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain T7SS_ESX1_EccB PF05108.13 EDK36989.2 - 0.12 11.0 0.0 0.17 10.5 0.0 1.2 1 0 0 1 1 1 0 Type VII secretion system ESX-1, transport TM domain B PTPLA PF04387.14 EDK36990.2 - 4.5e-16 59.0 7.3 4.5e-16 59.0 7.3 1.8 2 1 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA MFS_1 PF07690.16 EDK36991.2 - 8.7e-29 100.5 50.3 8.8e-23 80.8 33.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK36991.2 - 5.3 5.8 38.9 0.51 9.1 11.1 2.7 3 0 0 3 3 3 0 Sugar (and other) transporter bZIP_1 PF00170.21 EDK36992.1 - 5.9e-10 39.1 8.5 9.5e-10 38.4 8.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDK36992.1 - 7.8e-05 22.7 6.6 0.00014 21.9 6.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDK36992.1 - 0.0079 16.7 7.5 0.016 15.7 7.5 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Pex24p PF06398.11 EDK36993.1 - 0.19 10.7 8.0 0.22 10.5 8.0 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Calc_CGRP_IAPP PF00214.19 EDK36994.2 - 0.077 13.4 4.1 0.21 12.0 4.1 1.7 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family PAE PF03283.13 EDK36995.2 - 0.036 13.2 0.2 0.048 12.8 0.2 1.1 1 0 0 1 1 1 0 Pectinacetylesterase CDP-OH_P_transf PF01066.21 EDK36996.2 - 1.8e-15 57.4 0.3 1.8e-15 57.4 0.3 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MDD_C PF18376.1 EDK36997.2 - 6.8e-68 228.1 0.1 1.1e-67 227.4 0.1 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EDK36997.2 - 2.3e-10 40.5 0.9 4.6e-10 39.6 0.9 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain WD40 PF00400.32 EDK36998.2 - 1.6e-53 177.4 19.6 2e-10 41.0 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EDK36998.2 - 4.5e-29 100.6 10.5 7.5e-29 99.9 10.5 1.4 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EDK36998.2 - 1.3e-18 67.0 0.1 7.9e-05 22.9 0.0 5.7 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK36998.2 - 4.4e-06 25.9 0.1 1.2 8.0 0.0 4.1 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EDK36998.2 - 4.7e-06 26.1 0.0 0.31 10.3 0.0 4.7 2 1 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 EDK36998.2 - 6.3e-06 25.1 2.7 0.22 10.1 0.0 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 EDK36998.2 - 0.0001 22.2 0.0 6.2 6.9 0.0 4.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EDK36998.2 - 0.0034 15.5 0.0 0.0077 14.3 0.0 1.6 1 1 0 1 1 1 1 IKI3 family Nbas_N PF15492.6 EDK36998.2 - 0.0083 15.5 0.3 5.3 6.3 0.0 3.9 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Ret2_MD PF18528.1 EDK36998.2 - 0.0095 16.3 0.0 7.6 7.0 0.0 3.5 1 1 2 3 3 3 1 RNA editing 3' terminal uridylyl transferase 2 middle domain Cytochrom_D1 PF02239.16 EDK36998.2 - 0.045 12.3 0.1 0.2 10.2 0.1 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain MICSWaP PF17018.5 EDK36998.2 - 0.071 12.7 0.6 0.12 11.9 0.6 1.3 1 0 0 1 1 1 0 Spore wall protein DUF2458 PF10454.9 EDK36998.2 - 0.16 11.6 4.3 0.32 10.7 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) COX16 PF14138.6 EDK36999.1 - 5.1e-26 91.0 1.1 7.7e-26 90.4 1.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Arc_PepC_II PF06847.11 EDK36999.1 - 0.065 13.8 0.5 0.26 11.8 0.0 2.0 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II zf-LYAR PF08790.11 EDK37000.1 - 4.2e-16 58.5 2.9 4.2e-16 58.5 2.9 2.1 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger AAA_11 PF13086.6 EDK37000.1 - 0.0058 16.5 1.9 0.0063 16.3 1.9 1.2 1 0 0 1 1 1 1 AAA domain SLC12 PF03522.15 EDK37000.1 - 0.036 13.1 5.2 0.038 13.0 5.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF908 PF06012.12 EDK37000.1 - 0.096 12.1 4.1 0.12 11.8 4.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DM PF00751.18 EDK37000.1 - 0.12 12.3 2.3 0.24 11.3 2.3 1.5 1 0 0 1 1 1 0 DM DNA binding domain Mitofilin PF09731.9 EDK37000.1 - 0.22 10.3 10.9 0.26 10.1 10.9 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein zf-C2H2_4 PF13894.6 EDK37000.1 - 1.4 9.9 4.9 37 5.5 0.8 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Presenilin PF01080.17 EDK37000.1 - 8.3 5.1 5.7 9.9 4.8 5.7 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EDK37000.1 - 8.8 5.4 5.4 9.5 5.3 5.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Csm1 PF12539.8 EDK37001.2 - 6.5e-24 84.4 1.0 8.9e-24 83.9 0.1 1.7 2 0 0 2 2 2 1 Chromosome segregation protein Csm1/Pcs1 Cwf_Cwc_15 PF04889.12 EDK37001.2 - 0.00045 20.0 3.3 0.00058 19.7 3.3 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein UPF0242 PF06785.11 EDK37001.2 - 0.0041 17.3 7.2 0.0065 16.6 7.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus p25-alpha PF05517.12 EDK37001.2 - 0.014 15.6 1.7 0.023 14.9 1.7 1.3 1 0 0 1 1 1 0 p25-alpha DUF641 PF04859.12 EDK37001.2 - 0.019 15.3 2.6 0.034 14.5 2.6 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) LMBR1 PF04791.16 EDK37001.2 - 0.26 10.2 1.0 0.28 10.1 1.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CTD_bind PF04818.13 EDK37002.2 - 3.8e-19 69.3 0.0 1.1e-18 67.8 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. ANAPC4 PF12896.7 EDK37002.2 - 0.061 12.8 0.4 0.2 11.1 0.1 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 DUF948 PF06103.11 EDK37002.2 - 0.26 11.6 0.7 1.5 9.2 0.2 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) UvrD-helicase PF00580.21 EDK37003.2 - 1.2e-31 110.5 0.0 2.1e-15 57.1 0.1 2.3 1 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EDK37003.2 - 7.3e-30 104.5 0.0 1e-27 97.4 0.0 3.2 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EDK37003.2 - 7e-25 88.1 0.0 1.4e-23 83.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EDK37003.2 - 2.6e-10 40.0 0.8 4.3e-09 36.1 0.8 2.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EDK37003.2 - 3.8e-07 30.1 0.0 0.033 13.9 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EDK37003.2 - 9.7e-07 28.8 0.0 8.2e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDK37003.2 - 0.00013 21.8 0.0 0.0018 18.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EDK37003.2 - 0.0011 18.7 0.0 0.0025 17.6 0.0 1.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_12 PF13087.6 EDK37003.2 - 0.0016 18.1 0.0 0.12 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDK37003.2 - 0.013 15.4 0.0 0.059 13.2 0.0 2.0 2 0 0 2 2 2 0 Helicase ResIII PF04851.15 EDK37003.2 - 0.041 13.9 0.0 0.1 12.6 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Vps52 PF04129.12 EDK37004.2 - 4.9e-83 279.6 0.5 2.6e-55 188.1 0.4 2.1 1 1 1 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 EDK37004.2 - 5.8e-06 25.0 0.6 1e-05 24.2 0.6 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec3 Rep_fac_C PF08542.11 EDK37005.2 - 2.4e-24 85.5 0.0 9.9e-24 83.6 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 EDK37005.2 - 7.3e-12 45.9 0.0 1.4e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDK37005.2 - 1.5e-11 44.3 0.1 2.4e-09 37.2 0.1 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_3 PF07726.11 EDK37005.2 - 2.7e-07 30.5 0.0 4.6e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDK37005.2 - 1.5e-06 28.2 0.0 2.5e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDK37005.2 - 1.6e-05 24.7 0.0 4e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDK37005.2 - 2.8e-05 24.6 0.0 0.0041 17.5 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK37005.2 - 4.5e-05 23.7 0.1 0.16 12.2 0.1 2.4 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 EDK37005.2 - 0.00022 21.2 0.0 0.00054 19.9 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 EDK37005.2 - 0.00043 20.1 0.0 0.00081 19.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EDK37005.2 - 0.0021 17.5 0.0 0.034 13.5 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDK37005.2 - 0.021 15.2 0.1 0.095 13.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.13 EDK37005.2 - 0.021 14.6 0.1 0.03 14.1 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EDK37005.2 - 0.036 14.4 0.0 0.11 12.8 0.0 2.0 1 1 0 1 1 1 0 AAA C-terminal domain TniB PF05621.11 EDK37005.2 - 0.041 13.3 0.0 5.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 EDK37005.2 - 0.044 13.1 0.0 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family MeaB PF03308.16 EDK37005.2 - 0.046 12.7 0.0 0.51 9.3 0.0 2.2 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EDK37005.2 - 0.093 12.6 0.2 0.38 10.6 0.1 2.0 1 1 1 2 2 2 0 NTPase AAA_5 PF07728.14 EDK37005.2 - 0.16 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EDK37005.2 - 0.17 11.6 0.0 1 9.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain RNase_P_pop3 PF08228.11 EDK37006.2 - 6.3e-22 78.3 0.2 1.3e-20 74.0 0.2 2.1 1 1 0 1 1 1 1 RNase P subunit Pop3 RNA_pol_Rpb1_R PF05001.13 EDK37007.2 - 1.7e-05 24.9 76.5 0.037 14.4 16.2 4.4 2 1 0 4 4 4 4 RNA polymerase Rpb1 C-terminal repeat Filament_head PF04732.14 EDK37007.2 - 0.25 12.2 10.9 0.58 11.1 10.9 1.5 1 0 0 1 1 1 0 Intermediate filament head (DNA binding) region DEDD_Tnp_IS110 PF01548.17 EDK37007.2 - 0.61 9.9 4.5 0.19 11.6 0.7 1.9 1 1 1 2 2 2 0 Transposase RNA_pol_Rpb1_5 PF04998.17 EDK37008.1 - 7.1e-110 366.6 0.1 8.9e-110 366.3 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.14 EDK37008.1 - 2.8e-62 210.0 0.0 5.8e-62 208.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EDK37008.1 - 7.5e-51 171.7 3.3 1.5e-50 170.7 3.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EDK37008.1 - 1.4e-27 95.8 0.1 3.6e-27 94.4 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EDK37008.1 - 3.5e-09 36.5 193.8 0.35 11.3 2.9 10.0 9 0 0 9 9 9 9 RNA polymerase Rpb1 C-terminal repeat Herpes_BLLF1 PF05109.13 EDK37008.1 - 0.44 8.5 48.3 0.75 7.7 48.3 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) RNA_pol_Rpb1_2 PF00623.20 EDK37009.1 - 6.7e-78 260.6 0.0 8.6e-78 260.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDK37009.1 - 7.3e-16 58.5 0.0 1.1e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EDK37009.1 - 4.4e-09 36.1 0.7 7.2e-09 35.4 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_1 PF04997.12 EDK37010.1 - 1.4e-99 333.4 0.0 1.6e-99 333.2 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 Pro_isomerase PF00160.21 EDK37011.1 - 9.2e-48 162.5 0.1 1.4e-47 161.9 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 EDK37011.1 - 2.6e-06 27.0 6.5 0.00025 20.7 0.3 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK37011.1 - 2.7e-05 24.0 5.9 0.00032 20.6 0.4 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK37011.1 - 0.0018 18.5 1.1 0.041 14.2 0.9 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDK37011.1 - 0.0056 16.8 7.3 0.0098 16.0 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37011.1 - 0.024 15.4 0.9 0.079 13.8 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDK37011.1 - 0.42 11.4 2.3 1 10.2 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 EDK37012.2 - 1.1e-65 221.7 0.1 1.3e-65 221.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37012.2 - 3.7e-19 69.0 0.0 5.5e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDK37012.2 - 5.6e-07 29.7 0.1 1.1e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDK37012.2 - 0.0091 15.6 0.2 0.016 14.8 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EDK37012.2 - 0.035 12.9 0.0 0.082 11.7 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase CssAB PF16831.5 EDK37012.2 - 0.035 14.5 0.0 0.065 13.6 0.0 1.4 1 0 0 1 1 1 0 CS6 fimbrial subunits A and B, Coli surface antigen 6 Kdo PF06293.14 EDK37012.2 - 0.035 13.5 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LTV PF04180.14 EDK37013.2 - 2.5e-110 369.8 32.9 2.9e-110 369.6 32.9 1.0 1 0 0 1 1 1 1 Low temperature viability protein HAMP PF00672.25 EDK37013.2 - 0.057 13.8 0.1 0.14 12.5 0.1 1.7 1 0 0 1 1 1 0 HAMP domain MatE PF01554.18 EDK37014.2 - 2.9e-61 205.8 31.8 4.4e-34 117.5 9.8 2.6 3 0 0 3 3 3 2 MatE PIH1 PF08190.12 EDK37015.2 - 3.3e-23 82.0 1.1 4e-23 81.7 0.1 1.7 2 0 0 2 2 2 1 PIH1 N-terminal domain Pih1_fungal_CS PF18482.1 EDK37015.2 - 4.3e-08 33.6 0.1 1.1e-07 32.3 0.1 1.7 1 0 0 1 1 1 1 Fungal Pih1 CS domain ATG2_CAD PF13329.6 EDK37015.2 - 0.075 12.8 1.6 0.15 11.8 1.6 1.5 1 0 0 1 1 1 0 Autophagy-related protein 2 CAD motif BPL_N PF09825.9 EDK37016.2 - 5.5e-139 463.4 0.0 6.7e-139 463.1 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EDK37016.2 - 6.1e-19 68.2 0.0 1.1e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EDK37016.2 - 6e-10 38.9 0.1 1.5e-09 37.6 0.1 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain ThuA PF06283.11 EDK37016.2 - 0.024 14.8 0.0 0.063 13.5 0.0 1.7 2 0 0 2 2 2 0 Trehalose utilisation Glyco_hydro_42M PF08532.10 EDK37016.2 - 0.17 11.4 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 Beta-galactosidase trimerisation domain zf-ANAPC11 PF12861.7 EDK37017.2 - 1.9e-43 146.5 8.0 2.3e-43 146.2 8.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDK37017.2 - 6.6e-22 77.6 9.4 9.3e-22 77.1 9.4 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDK37017.2 - 7e-08 32.7 14.2 1.2e-06 28.7 14.0 2.5 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EDK37017.2 - 8e-05 22.4 11.4 0.00025 20.9 11.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK37017.2 - 0.0015 18.5 8.7 0.0099 15.9 5.1 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 EDK37017.2 - 0.0032 17.2 10.5 0.01 15.6 0.6 2.8 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EDK37017.2 - 0.0076 16.4 2.8 0.0076 16.4 2.8 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EDK37017.2 - 0.015 15.1 16.8 0.046 13.6 14.1 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 EDK37017.2 - 0.041 14.4 3.8 0.05 14.1 0.2 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain PHD PF00628.29 EDK37017.2 - 0.22 11.4 11.6 0.73 9.8 11.6 1.9 1 1 0 1 1 1 0 PHD-finger zf-HIT PF04438.16 EDK37017.2 - 0.27 11.1 6.8 0.13 12.2 2.6 2.1 2 0 0 2 2 2 0 HIT zinc finger zf-RING_11 PF17123.5 EDK37017.2 - 0.37 10.6 9.6 3.3 7.5 9.6 2.4 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EDK37017.2 - 0.44 10.2 10.2 0.31 10.7 6.9 2.1 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EDK37017.2 - 0.5 10.3 11.9 18 5.3 12.0 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK37017.2 - 0.85 9.6 13.5 8.1 6.5 13.7 2.4 1 1 1 2 2 2 0 zinc-RING finger domain DZR PF12773.7 EDK37017.2 - 1.2 9.2 9.4 1.1 9.3 2.9 2.3 2 1 0 2 2 2 0 Double zinc ribbon zf-HC5HC2H_2 PF13832.6 EDK37017.2 - 1.5 9.0 7.2 0.55 10.4 3.9 1.9 1 1 1 2 2 2 0 PHD-zinc-finger like domain RINGv PF12906.7 EDK37017.2 - 1.9 8.7 9.0 5.8 7.1 9.0 1.9 1 1 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 EDK37017.2 - 1.9 8.4 16.0 1.8 8.6 0.2 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EDK37017.2 - 2.3 8.5 17.6 69 3.7 17.6 3.3 1 1 0 1 1 1 0 FANCL C-terminal domain UbiA PF01040.18 EDK37018.2 - 7.1e-50 169.7 13.0 9.1e-50 169.3 13.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3953 PF13129.6 EDK37019.2 - 0.12 12.2 0.9 0.42 10.4 0.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) AA_kinase PF00696.28 EDK37021.2 - 1.3e-38 132.9 0.9 2.2e-38 132.2 0.9 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EDK37021.2 - 5e-14 52.0 0.0 9.6e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 PUA domain SurE PF01975.17 EDK37022.1 - 6.8e-42 143.5 0.0 1.4e-41 142.5 0.0 1.5 1 1 0 1 1 1 1 Survival protein SurE Metallophos PF00149.28 EDK37024.2 - 3.3e-38 132.2 0.2 4.4e-38 131.9 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDK37024.2 - 0.014 15.8 0.1 0.031 14.7 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain DUF5378 PF17349.2 EDK37024.2 - 0.043 13.1 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Glyco_hydro_65N PF03636.15 EDK37024.2 - 0.1 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Ribosomal_S18 PF01084.20 EDK37025.1 - 2.2e-19 69.4 0.0 4.3e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 MFS_1 PF07690.16 EDK37026.2 - 7.1e-37 127.1 34.6 7.1e-37 127.1 34.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK37026.2 - 6.3e-16 58.3 8.9 6.3e-16 58.3 8.9 2.6 1 1 2 3 3 3 1 Sugar (and other) transporter PI-PLC-X PF00388.19 EDK37026.2 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain HMGL-like PF00682.19 EDK37028.2 - 1.4e-83 280.5 0.1 1.6e-83 280.3 0.1 1.0 1 0 0 1 1 1 1 HMGL-like EXS PF03124.14 EDK37029.2 - 2.2e-99 332.9 31.4 3.4e-99 332.3 31.4 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EDK37029.2 - 4.1e-54 185.0 24.3 2.2e-40 139.8 15.5 2.4 2 1 1 3 3 3 2 SPX domain Abhydrolase_6 PF12697.7 EDK37030.2 - 5.2e-17 63.2 0.0 8.1e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDK37030.2 - 2.3e-13 50.4 0.1 5.6e-13 49.1 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DSPc PF00782.20 EDK37030.2 - 3e-12 46.5 0.0 1.1e-11 44.7 0.0 2.0 2 0 0 2 2 1 1 Dual specificity phosphatase, catalytic domain Hydrolase_4 PF12146.8 EDK37030.2 - 9.8e-10 38.1 0.0 3.8e-09 36.2 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDK37030.2 - 5.9e-07 29.5 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 EDK37030.2 - 6.7e-07 29.1 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 EDK37030.2 - 5.4e-06 26.7 0.0 0.00047 20.3 0.0 2.4 2 0 0 2 2 2 1 Thioesterase domain Chlorophyllase2 PF12740.7 EDK37030.2 - 1.7e-05 23.9 0.1 3.8e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 EDK37030.2 - 6.9e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_5 PF12695.7 EDK37030.2 - 0.00031 20.6 0.0 0.0021 17.9 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF900 PF05990.12 EDK37030.2 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DSPn PF14671.6 EDK37030.2 - 0.0014 19.1 0.0 0.04 14.4 0.0 2.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half Esterase PF00756.20 EDK37030.2 - 0.0018 18.0 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Y_phosphatase PF00102.27 EDK37030.2 - 0.0049 16.5 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Abhydrolase_3 PF07859.13 EDK37030.2 - 0.014 15.3 0.0 0.037 13.9 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EDK37030.2 - 0.018 14.9 0.1 0.13 12.1 0.1 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EDK37030.2 - 0.019 14.9 0.0 0.65 9.9 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ribonuc_2-5A PF06479.12 EDK37030.2 - 0.031 14.5 0.2 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Ribonuclease 2-5A DUF2974 PF11187.8 EDK37030.2 - 0.042 13.4 0.0 0.22 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF3089 PF11288.8 EDK37030.2 - 0.055 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) LCAT PF02450.15 EDK37030.2 - 0.061 12.5 0.1 0.18 10.9 0.0 1.8 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase PTPlike_phytase PF14566.6 EDK37030.2 - 0.08 13.1 0.2 0.52 10.4 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate Lipase_3 PF01764.25 EDK37030.2 - 0.082 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF1057 PF06342.12 EDK37030.2 - 0.094 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.18 EDK37030.2 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Y_phosphatase3 PF13350.6 EDK37030.2 - 0.16 11.9 0.0 0.8 9.6 0.0 2.1 3 0 0 3 3 3 0 Tyrosine phosphatase family PhoLip_ATPase_N PF16209.5 EDK37031.2 - 1e-12 47.5 4.0 1e-12 47.5 4.0 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDK37032.2 - 4e-14 52.6 0.1 1.1e-13 51.1 0.0 1.8 1 1 0 1 1 1 1 E1-E2 ATPase Prot_ATP_ID_OB PF16450.5 EDK37032.2 - 0.0019 18.1 0.2 0.0083 16.1 0.1 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain DUF2269 PF10027.9 EDK37032.2 - 0.0078 16.3 0.3 0.071 13.2 0.2 2.1 2 0 0 2 2 2 1 Predicted integral membrane protein (DUF2269) PhoLip_ATPase_C PF16212.5 EDK37033.2 - 2e-49 168.6 14.4 2.6e-49 168.2 14.4 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EDK37033.2 - 3.6e-07 30.7 0.0 0.0081 16.5 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK37033.2 - 0.0059 16.4 0.1 0.014 15.1 0.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2070 PF09843.9 EDK37033.2 - 0.25 9.6 11.5 0.4 8.9 11.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ATP-synt_ab PF00006.25 EDK37035.1 - 6.4e-71 238.4 0.0 8.7e-71 237.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDK37035.1 - 1.3e-48 164.5 1.0 2.1e-48 163.8 1.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EDK37035.1 - 6.8e-05 23.3 0.1 0.00018 22.0 0.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RbcS PF12338.8 EDK37035.1 - 0.053 13.7 0.1 3 8.1 0.2 2.7 2 0 0 2 2 2 0 Ribulose-1,5-bisphosphate carboxylase small subunit Ndc1_Nup PF09531.10 EDK37036.2 - 0.022 13.4 4.3 0.024 13.3 4.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Use1 PF09753.9 EDK37036.2 - 0.24 11.1 8.2 5.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Membrane fusion protein Use1 Peptidase_M1 PF01433.20 EDK37038.2 - 1e-83 280.3 0.8 2.1e-83 279.2 0.8 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDK37038.2 - 1.4e-81 274.5 5.1 8.2e-81 272.0 2.4 2.2 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDK37038.2 - 3.5e-52 177.3 3.3 3.5e-52 177.3 1.4 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Dynamin_M PF01031.20 EDK37039.2 - 1.2e-109 366.0 0.0 2.6e-109 364.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EDK37039.2 - 8.2e-55 185.4 0.2 8.2e-55 185.4 0.2 2.2 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EDK37039.2 - 2.2e-28 98.3 5.0 5.2e-28 97.1 5.0 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDK37039.2 - 0.00053 20.1 0.3 0.0063 16.6 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK37039.2 - 0.013 15.0 0.1 3.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.27 EDK37039.2 - 0.033 14.7 0.0 0.17 12.4 0.0 2.2 1 0 0 1 1 1 0 ABC transporter Saw1 PF11561.8 EDK37040.2 - 1.3e-07 31.4 4.6 1.3e-07 31.4 4.6 1.8 1 1 1 2 2 2 1 Single strand annealing-weakened 1 Anp1 PF03452.14 EDK37041.2 - 1.9e-67 227.5 0.4 2.2e-67 227.2 0.4 1.0 1 0 0 1 1 1 1 Anp1 Mycobact_memb PF05423.13 EDK37041.2 - 0.0082 16.1 0.0 0.026 14.4 0.0 1.8 2 0 0 2 2 2 1 Mycobacterium membrane protein Glycos_transf_2 PF00535.26 EDK37041.2 - 0.011 15.5 0.1 0.022 14.6 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Lentiviral_Tat PF02998.14 EDK37041.2 - 0.18 11.9 0.2 0.45 10.6 0.2 1.6 1 0 0 1 1 1 0 Lentiviral Tat protein HAT_KAT11 PF08214.11 EDK37042.2 - 1.1e-109 366.9 1.0 1.4e-109 366.6 1.0 1.0 1 0 0 1 1 1 1 Histone acetylation protein SpoVIF PF14069.6 EDK37042.2 - 0.029 14.2 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 Stage VI sporulation protein F DivIC PF04977.15 EDK37043.2 - 0.00014 21.6 7.9 0.0015 18.2 1.9 2.4 2 0 0 2 2 2 1 Septum formation initiator TolA_bind_tri PF16331.5 EDK37043.2 - 0.00059 19.9 8.8 0.066 13.3 1.6 2.5 2 0 0 2 2 2 2 TolA binding protein trimerisation HALZ PF02183.18 EDK37043.2 - 0.0014 18.8 4.2 0.0014 18.8 4.2 2.4 2 0 0 2 2 2 1 Homeobox associated leucine zipper PRKG1_interact PF15898.5 EDK37043.2 - 0.0015 19.4 9.8 0.0015 19.4 9.8 2.0 1 1 1 2 2 2 1 cGMP-dependent protein kinase interacting domain bZIP_1 PF00170.21 EDK37043.2 - 0.0026 17.8 1.2 0.0026 17.8 1.2 2.6 2 1 0 2 2 2 1 bZIP transcription factor ZapB PF06005.12 EDK37043.2 - 0.0039 17.6 9.8 0.054 14.0 3.5 2.3 2 0 0 2 2 2 1 Cell division protein ZapB Csm1_N PF18504.1 EDK37043.2 - 0.0086 16.4 8.8 0.12 12.7 1.1 2.4 2 0 0 2 2 2 2 Csm1 N-terminal domain Cnn_1N PF07989.11 EDK37043.2 - 0.018 15.2 1.3 0.018 15.2 1.3 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Cep57_CLD_2 PF14197.6 EDK37043.2 - 0.022 14.9 10.3 0.32 11.1 4.1 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 SlyX PF04102.12 EDK37043.2 - 0.026 15.1 8.3 0.041 14.5 0.6 2.4 2 0 0 2 2 2 0 SlyX JIP_LZII PF16471.5 EDK37043.2 - 0.038 14.2 8.3 0.092 12.9 1.4 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II CtIP_N PF10482.9 EDK37043.2 - 0.056 13.5 4.8 0.67 10.0 0.6 2.3 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain TSC22 PF01166.18 EDK37043.2 - 0.065 13.5 5.9 0.26 11.6 0.7 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family DUF5320 PF17253.2 EDK37043.2 - 0.067 14.3 2.0 0.73 10.9 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) HMMR_C PF15908.5 EDK37043.2 - 0.15 12.3 7.0 1.7 8.9 1.1 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal KLRAQ PF10205.9 EDK37043.2 - 0.16 12.2 6.6 2.2 8.6 0.6 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein bZIP_2 PF07716.15 EDK37043.2 - 0.25 11.5 14.8 0.74 9.9 4.2 2.6 2 0 0 2 2 2 0 Basic region leucine zipper YabA PF06156.13 EDK37043.2 - 0.32 11.6 8.5 0.41 11.3 1.7 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Fungal_TACC PF12709.7 EDK37043.2 - 0.33 11.4 5.3 0.71 10.4 0.6 2.4 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins KfrA_N PF11740.8 EDK37043.2 - 0.33 11.6 9.9 3.2 8.5 0.1 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term CCDC92 PF14916.6 EDK37043.2 - 0.41 10.4 5.3 1.5 8.7 0.1 2.6 2 0 0 2 2 2 0 Coiled-coil domain of unknown function GIT_CC PF16559.5 EDK37043.2 - 0.42 10.5 7.0 4.7 7.1 0.9 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1640 PF07798.11 EDK37043.2 - 0.51 10.4 10.9 10 6.1 10.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Rootletin PF15035.6 EDK37043.2 - 0.63 10.0 11.5 1.9 8.5 11.5 1.9 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TMCO5 PF14992.6 EDK37043.2 - 0.99 8.9 9.0 0.074 12.6 2.1 2.1 1 1 1 2 2 2 0 TMCO5 family JAKMIP_CC3 PF16034.5 EDK37043.2 - 1.4 8.9 14.2 2.5 8.0 13.5 1.9 1 1 0 1 1 1 0 JAKMIP CC3 domain bZIP_Maf PF03131.17 EDK37043.2 - 1.8 9.1 8.1 1.5 9.4 1.9 2.4 2 0 0 2 2 2 0 bZIP Maf transcription factor Vps51 PF08700.11 EDK37043.2 - 2 8.5 9.9 3.8 7.6 0.3 3.1 3 1 0 3 3 3 0 Vps51/Vps67 DUF4140 PF13600.6 EDK37043.2 - 2.2 8.8 11.9 3.6 8.1 2.7 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) G-gamma PF00631.22 EDK37043.2 - 3.4 7.8 5.6 4.4 7.4 0.5 2.5 2 0 0 2 2 2 0 GGL domain DUF4094 PF13334.6 EDK37043.2 - 4.1 7.9 8.1 1 9.8 1.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF4482 PF14818.6 EDK37043.2 - 4.4 8.2 10.5 1.4 9.8 6.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) APG6_N PF17675.1 EDK37043.2 - 4.8 7.7 13.5 12 6.5 13.0 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region FAM76 PF16046.5 EDK37043.2 - 7.7 5.8 11.5 11 5.3 11.5 1.2 1 0 0 1 1 1 0 FAM76 protein Polysacc_deac_1 PF01522.21 EDK37044.2 - 4.3e-26 91.2 0.0 6.7e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EDK37044.2 - 0.0044 16.3 0.0 0.0057 15.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 MRP-L28 PF09812.9 EDK37045.2 - 0.069 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 DUF1804 PF08822.11 EDK37045.2 - 0.096 12.7 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) NAP PF00956.18 EDK37046.2 - 1.1e-93 313.4 12.0 1.1e-93 313.4 12.0 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) BUD22 PF09073.10 EDK37046.2 - 0.00019 20.9 24.0 0.0058 16.0 1.1 2.1 2 0 0 2 2 2 2 BUD22 DUF2738 PF10927.8 EDK37046.2 - 0.043 12.9 1.6 0.68 9.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2738) DUF1676 PF07898.13 EDK37046.2 - 0.52 10.3 6.3 0.19 11.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Adeno_terminal PF02459.15 EDK37046.2 - 2.7 6.3 8.9 7.9 4.7 0.1 2.2 2 0 0 2 2 2 0 Adenoviral DNA terminal protein ABC_membrane_2 PF06472.15 EDK37047.2 - 3.8e-85 285.5 3.9 6.5e-85 284.8 3.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDK37047.2 - 4.2e-20 72.7 0.0 1.3e-19 71.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 EDK37047.2 - 5.3e-06 27.1 2.9 8.9e-06 26.3 1.6 2.0 2 0 0 2 2 1 1 AAA domain SMC_N PF02463.19 EDK37047.2 - 0.0026 17.2 1.8 1.5 8.2 0.0 3.0 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK37047.2 - 0.0056 16.5 4.9 0.013 15.4 0.1 3.3 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EDK37047.2 - 0.0084 15.8 0.1 0.016 14.9 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EDK37047.2 - 0.02 15.3 0.1 0.085 13.3 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDK37047.2 - 0.068 12.9 0.0 0.3 10.8 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EDK37047.2 - 0.078 12.7 0.2 2.2 8.0 0.1 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDK37047.2 - 0.087 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDK37047.2 - 0.1 12.6 0.0 2 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDK37047.2 - 0.14 12.6 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain CTP_transf_like PF01467.26 EDK37048.1 - 6.1e-32 110.8 0.0 8.6e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Aconitase PF00330.20 EDK37049.1 - 2.4e-163 544.4 0.0 3e-163 544.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDK37049.1 - 2.2e-44 150.9 0.0 4.8e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain APG5 PF04106.12 EDK37050.2 - 4e-36 124.7 0.3 5.1e-36 124.4 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 YjeF_N PF03853.15 EDK37052.1 - 1e-35 123.1 0.0 1.3e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Septin PF00735.18 EDK37053.2 - 3.1e-54 184.2 0.1 3.1e-54 184.2 0.1 2.2 2 0 0 2 2 2 1 Septin ANT PF03374.14 EDK37053.2 - 0.0077 16.5 0.9 0.019 15.3 0.9 1.7 1 0 0 1 1 1 1 Phage antirepressor protein KilAC domain Synaptobrevin PF00957.21 EDK37053.2 - 0.097 12.5 1.5 0.27 11.0 1.5 1.8 1 0 0 1 1 1 0 Synaptobrevin HEAT PF02985.22 EDK37054.2 - 2.8e-15 55.1 20.4 0.0016 18.5 0.1 11.7 12 0 0 12 12 12 4 HEAT repeat HEAT_EZ PF13513.6 EDK37054.2 - 5.5e-15 55.5 24.3 3.1e-10 40.3 0.2 9.3 9 1 2 11 11 11 2 HEAT-like repeat IBN_N PF03810.19 EDK37054.2 - 4.3e-10 39.4 1.9 1.3e-09 37.8 1.9 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDK37054.2 - 3.8e-08 33.6 17.0 0.025 15.0 0.1 7.1 2 2 4 7 7 7 3 HEAT repeats Arm PF00514.23 EDK37054.2 - 4e-08 33.0 3.1 0.0046 17.0 0.1 5.9 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EDK37054.2 - 0.00025 20.7 0.0 4.5 6.8 0.0 4.8 4 1 1 5 5 5 1 CLASP N terminal TIP120 PF08623.10 EDK37054.2 - 0.00037 20.3 0.3 0.0049 16.6 0.0 2.9 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) Cnd1 PF12717.7 EDK37054.2 - 0.0027 17.8 0.4 0.11 12.5 0.0 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 PAP2 PF01569.21 EDK37055.2 - 1.9e-20 73.0 2.1 3e-20 72.4 2.1 1.3 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 EDK37055.2 - 0.046 13.8 2.4 6.6 6.9 0.3 2.3 1 1 1 2 2 2 0 Divergent PAP2 family PTP_tm PF18861.1 EDK37055.2 - 0.085 12.8 0.6 0.13 12.3 0.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Transmemb_17 PF09799.9 EDK37055.2 - 0.34 11.5 8.1 0.22 12.1 3.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein WTF PF03303.13 EDK37055.2 - 0.34 10.6 6.0 1.1 8.9 2.3 2.1 2 0 0 2 2 2 0 WTF protein ArfGap PF01412.18 EDK37056.2 - 1.1e-31 109.4 0.0 2.5e-31 108.2 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf adh_short_C2 PF13561.6 EDK37057.2 - 9.7e-45 152.9 1.2 1.3e-44 152.6 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK37057.2 - 1.3e-34 119.4 1.0 1.6e-34 119.1 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK37057.2 - 6e-11 42.6 1.0 8.5e-11 42.1 1.0 1.1 1 0 0 1 1 1 1 KR domain SMK-1 PF04802.15 EDK37058.2 - 6e-44 150.2 6.2 4e-43 147.5 0.8 3.1 3 0 0 3 3 3 2 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 EDK37058.2 - 0.0022 17.9 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 WH1 domain HEAT PF02985.22 EDK37058.2 - 0.35 11.2 1.1 59 4.3 0.2 3.3 3 0 0 3 3 3 0 HEAT repeat ATP12 PF07542.11 EDK37059.2 - 7.1e-35 119.9 0.1 1.1e-34 119.3 0.1 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.20 EDK37060.2 - 8.7e-10 38.5 4.2 1.1e-09 38.2 4.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit TolA_bind_tri PF16331.5 EDK37060.2 - 0.037 14.1 2.7 0.037 14.1 2.7 1.8 2 0 0 2 2 2 0 TolA binding protein trimerisation hSH3 PF14603.6 EDK37060.2 - 0.046 14.2 0.1 0.063 13.7 0.1 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain DUF5320 PF17253.2 EDK37060.2 - 0.15 13.2 0.2 0.24 12.5 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Gon7 PF08738.10 EDK37061.1 - 3.5e-31 107.5 0.0 3.8e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Gon7 family 6PF2K PF01591.18 EDK37062.2 - 1e-59 201.6 0.2 1.5e-59 201.0 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDK37062.2 - 1.1e-14 54.6 0.0 5.3e-13 49.1 0.0 2.3 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDK37062.2 - 0.0045 17.2 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK37062.2 - 0.0082 16.7 0.0 0.052 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EDK37062.2 - 0.046 13.6 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase IstB_IS21 PF01695.17 EDK37062.2 - 0.087 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Ribosomal_L26 PF16906.5 EDK37063.1 - 2.5e-26 92.0 0.6 3.1e-26 91.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EDK37063.1 - 0.0048 16.8 1.0 0.0072 16.3 0.1 1.8 2 1 0 2 2 2 1 KOW motif TIM21 PF08294.11 EDK37064.1 - 9.3e-44 148.8 0.0 1.1e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 TIM21 PRIMA1 PF16101.5 EDK37064.1 - 0.0055 16.7 0.6 0.0089 16.1 0.6 1.3 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Acetyltransf_16 PF05301.11 EDK37064.1 - 0.21 11.4 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 CAP_N PF01213.19 EDK37064.1 - 0.91 8.9 4.5 1.3 8.4 4.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Arf PF00025.21 EDK37066.2 - 1.9e-54 183.8 3.6 2.1e-54 183.6 3.6 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK37066.2 - 3.6e-14 52.7 0.3 4.5e-14 52.4 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EDK37066.2 - 1.3e-13 51.3 0.5 2.1e-13 50.5 0.5 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK37066.2 - 1.3e-11 44.4 0.2 1.6e-11 44.0 0.2 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDK37066.2 - 2.5e-11 43.3 4.3 2.6e-07 30.1 1.9 2.4 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 EDK37066.2 - 7.3e-08 32.2 0.1 1.2e-07 31.5 0.1 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDK37066.2 - 4.7e-07 29.4 0.0 6e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDK37066.2 - 1.2e-05 25.4 0.0 2.5e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EDK37066.2 - 0.00096 18.8 0.2 0.0024 17.5 0.2 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 EDK37066.2 - 0.016 15.2 0.1 0.03 14.3 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain CdhD PF03599.16 EDK37066.2 - 0.039 12.7 0.0 0.051 12.3 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DRMBL PF07522.14 EDK37067.2 - 7.9e-22 77.5 0.0 2.1e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 EDK37067.2 - 0.008 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Glyco_transf_34 PF05637.12 EDK37068.2 - 3.5e-49 167.7 0.5 5.2e-49 167.1 0.5 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF1751 PF08551.10 EDK37069.2 - 4.9e-26 91.2 4.9 1.3e-25 89.9 4.9 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EDK37069.2 - 0.00054 20.0 6.9 0.0011 18.9 6.9 1.5 1 0 0 1 1 1 1 Rhomboid family UPF0239 PF06783.11 EDK37069.2 - 0.046 13.9 0.3 10 6.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Glucan_synthase PF02364.15 EDK37070.2 - 0 1326.6 0.0 0 1322.8 0.0 2.1 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDK37070.2 - 1.7e-39 135.1 0.2 1.7e-39 135.1 0.2 2.1 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Herpes_US9 PF06072.11 EDK37070.2 - 5 7.1 5.3 1.1 9.2 0.8 2.3 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 eIF2A PF08662.11 EDK37071.2 - 3.4e-43 147.8 0.0 4.6e-43 147.3 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Enkurin PF13864.6 EDK37071.2 - 0.026 15.0 2.6 0.026 15.0 2.6 1.7 2 0 0 2 2 2 0 Calmodulin-binding CDV3 PF15359.6 EDK37071.2 - 0.033 14.7 0.9 0.033 14.7 0.9 2.4 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Mcm10 PF09332.11 EDK37071.2 - 1.1 8.6 10.2 0.15 11.5 6.1 1.5 2 0 0 2 2 2 0 Mcm10 replication factor Pol_alpha_B_N PF08418.10 EDK37071.2 - 1.3 8.9 6.6 2 8.3 6.6 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal OTU PF02338.19 EDK37072.2 - 1.9e-05 25.2 0.0 3.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Ribosomal_L16 PF00252.18 EDK37073.1 - 5.1e-41 139.8 0.1 6.4e-41 139.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PMM PF03332.13 EDK37074.1 - 6e-113 376.0 0.8 6.9e-113 375.9 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EDK37074.1 - 1.8e-05 24.6 0.0 7.3e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDK37074.1 - 0.014 15.0 0.0 0.36 10.3 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase RCC1 PF00415.18 EDK37075.2 - 7.1e-28 97.0 0.3 1.1e-07 32.3 0.1 6.5 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDK37075.2 - 3.2e-21 74.6 7.8 1.4e-08 34.3 0.9 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat TNV_CP PF03898.13 EDK37075.2 - 0.13 11.6 0.0 0.28 10.4 0.0 1.5 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF1640 PF07798.11 EDK37076.2 - 2.5e-57 193.7 6.0 2.8e-57 193.6 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) XhlA PF10779.9 EDK37076.2 - 0.0054 16.9 5.7 0.15 12.3 0.0 2.3 2 0 0 2 2 2 1 Haemolysin XhlA Uds1 PF15456.6 EDK37076.2 - 0.015 15.4 4.6 0.026 14.7 4.6 1.4 1 0 0 1 1 1 0 Up-regulated During Septation DUF5082 PF16888.5 EDK37076.2 - 0.026 14.8 9.3 0.38 11.1 1.5 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) FlaC_arch PF05377.11 EDK37076.2 - 0.041 14.3 5.7 0.55 10.7 0.9 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HALZ PF02183.18 EDK37076.2 - 0.041 14.1 4.2 0.092 13.0 4.2 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper Fungal_TACC PF12709.7 EDK37076.2 - 0.053 14.0 6.6 0.17 12.3 1.7 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins GTP-bdg_M PF16360.5 EDK37076.2 - 0.074 13.7 2.6 3.7 8.2 3.3 2.9 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region DUF3158 PF11358.8 EDK37076.2 - 0.13 11.9 3.3 0.069 12.9 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3158) Lectin_N PF03954.14 EDK37076.2 - 0.15 11.8 4.7 0.7 9.6 4.4 2.0 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Mt_ATP-synt_D PF05873.12 EDK37076.2 - 0.27 11.1 4.7 0.32 10.9 0.3 2.1 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF2203 PF09969.9 EDK37076.2 - 0.76 10.5 6.9 3.3 8.5 1.8 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 EDK37076.2 - 1.8 9.2 6.3 30 5.3 0.3 3.1 2 1 0 2 2 2 0 SlyX DivIC PF04977.15 EDK37076.2 - 2.3 8.1 8.8 6.6 6.6 3.6 2.6 2 1 0 2 2 2 0 Septum formation initiator Baculo_PEP_C PF04513.12 EDK37076.2 - 2.4 8.2 8.5 5.5 7.0 4.3 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cnn_1N PF07989.11 EDK37076.2 - 4.7 7.4 13.3 20 5.4 5.4 2.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 YabA PF06156.13 EDK37076.2 - 5.7 7.6 10.7 9.6 6.9 5.1 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 EDK37076.2 - 7.7 6.6 8.7 14 5.7 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) V-SNARE_C PF12352.8 EDK37077.2 - 4.3e-14 52.5 1.2 4.3e-14 52.5 1.2 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EDK37077.2 - 4.1e-09 36.2 0.8 2.6e-08 33.7 0.0 2.3 2 1 1 3 3 3 1 Sec20 Sigma70_r4 PF04545.16 EDK37077.2 - 0.0019 17.7 0.4 0.0039 16.7 0.1 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 DUF4047 PF13256.6 EDK37077.2 - 0.003 17.7 2.4 0.13 12.4 0.2 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4047) EzrA PF06160.12 EDK37077.2 - 0.0042 15.3 2.9 0.11 10.7 0.1 2.1 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA V_ATPase_I PF01496.19 EDK37077.2 - 0.013 13.5 2.3 0.014 13.4 2.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SHE3 PF17078.5 EDK37077.2 - 0.035 13.8 5.9 0.022 14.5 3.8 1.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 TPR_MLP1_2 PF07926.12 EDK37077.2 - 0.1 12.7 7.9 0.22 11.6 6.9 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 EDK37077.2 - 0.35 11.2 4.8 7 7.0 0.3 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein CENP-Q PF13094.6 EDK37077.2 - 0.51 10.5 8.3 0.86 9.8 8.3 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit YabA PF06156.13 EDK37077.2 - 0.8 10.4 7.2 0.95 10.1 2.8 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 EDK37077.2 - 0.99 8.2 8.1 4.8 6.0 0.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF16 PF01519.16 EDK37077.2 - 6.4 7.3 8.1 3.6 8.1 4.0 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Glyco_hydro_17 PF00332.18 EDK37078.2 - 1.3e-09 38.1 5.7 1.9e-08 34.3 0.3 2.4 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 GSH_synth_ATP PF03917.17 EDK37078.2 - 0.12 11.2 0.0 0.14 10.9 0.0 1.3 1 1 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain DUF2076 PF09849.9 EDK37078.2 - 0.26 11.3 13.8 0.17 11.9 2.3 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) Bromodomain PF00439.25 EDK37079.2 - 1.5e-30 105.1 1.2 1.1e-15 57.5 0.6 2.7 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EDK37079.2 - 2.2e-18 66.3 0.0 5e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 BAH domain SIR2 PF02146.17 EDK37080.2 - 1.9e-41 141.9 0.0 3.7e-41 141.0 0.0 1.5 1 1 0 1 1 1 1 Sir2 family Glyco_transf_28 PF03033.20 EDK37080.2 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Rad50_zn_hook PF04423.14 EDK37080.2 - 7.3 6.5 5.5 1.4 8.8 1.6 1.8 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF3678 PF12435.8 EDK37081.2 - 0.4 10.1 3.9 1.1 8.7 3.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3678) Pyr_redox_2 PF07992.14 EDK37082.2 - 1.8e-68 230.9 7.6 2.5e-68 230.5 6.8 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDK37082.2 - 1.7e-42 144.1 0.1 4.2e-42 142.9 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDK37082.2 - 2e-19 69.9 10.0 2.5e-18 66.4 2.1 3.2 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDK37082.2 - 2.3e-12 46.7 5.7 7.4e-11 41.8 1.3 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EDK37082.2 - 5.5e-11 42.3 4.9 1.8e-08 34.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK37082.2 - 1.1e-09 38.4 1.9 0.0011 19.2 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EDK37082.2 - 8.4e-09 35.3 9.7 4.8e-08 32.8 0.3 3.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK37082.2 - 3.6e-06 26.3 11.0 6.6e-06 25.5 0.7 3.7 3 1 1 4 4 4 1 FAD binding domain FAD_binding_3 PF01494.19 EDK37082.2 - 4.8e-06 26.1 7.0 0.013 14.7 1.7 2.9 2 1 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EDK37082.2 - 1.2e-05 24.6 2.4 0.0034 16.7 0.1 2.4 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 EDK37082.2 - 2.6e-05 23.1 10.7 0.0031 16.3 0.4 3.9 3 1 1 4 4 4 2 HI0933-like protein AlaDh_PNT_C PF01262.21 EDK37082.2 - 4.6e-05 22.8 3.1 0.0036 16.6 0.3 3.1 3 1 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 EDK37082.2 - 0.00034 19.9 3.4 0.095 11.8 0.0 2.4 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EDK37082.2 - 0.0004 20.1 13.6 0.079 12.5 2.0 3.7 3 1 1 4 4 4 3 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EDK37082.2 - 0.0052 16.7 1.0 0.0052 16.7 1.0 2.2 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EDK37082.2 - 0.01 14.9 2.5 0.88 8.6 0.0 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein UDPG_MGDP_dh_N PF03721.14 EDK37082.2 - 0.31 10.6 2.9 0.19 11.3 0.2 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EDK37082.2 - 0.88 10.0 3.4 19 5.7 0.5 3.6 3 1 0 3 3 3 0 Putative NAD(P)-binding Pmp3 PF01679.17 EDK37083.1 - 8.4e-23 80.3 5.7 9.5e-23 80.2 5.7 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator tRNA-synt_2d PF01409.20 EDK37084.1 - 4e-88 295.0 0.0 5.5e-88 294.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EDK37084.1 - 1.3e-16 60.6 2.3 4.5e-16 58.9 0.2 2.8 3 0 0 3 3 3 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EDK37084.1 - 1.9e-09 37.3 0.0 5.1e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2b PF00587.25 EDK37084.1 - 9.3e-06 25.7 0.0 2.4e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) PheRS_DBD2 PF18554.1 EDK37084.1 - 2.5e-05 24.1 1.4 6.3e-05 22.9 1.4 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 EDK37084.1 - 0.0005 19.2 0.1 0.012 14.8 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) zf-H2C2_2 PF13465.6 EDK37085.2 - 1.3e-06 28.6 0.5 1.3e-06 28.6 0.5 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDK37085.2 - 0.00014 22.1 1.5 0.61 10.7 0.0 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EDK37085.2 - 0.0016 19.0 10.8 0.64 10.7 0.0 4.1 3 1 1 4 4 4 2 FOXP coiled-coil domain SYCE1 PF15233.6 EDK37085.2 - 0.023 14.8 0.8 0.043 13.9 0.8 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 zf-C2H2_4 PF13894.6 EDK37085.2 - 0.057 14.3 2.2 5.9 8.0 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EDK37085.2 - 6.2 6.7 6.8 2.9 7.7 0.2 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Fcf2 PF08698.11 EDK37086.2 - 8.9e-36 122.2 0.1 8.9e-36 122.2 0.1 2.1 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing DNA_primase_S PF01896.19 EDK37086.2 - 0.027 14.5 0.2 0.032 14.3 0.2 1.2 1 0 0 1 1 1 0 DNA primase small subunit Com_YlbF PF06133.11 EDK37086.2 - 0.11 13.1 0.7 0.11 13.1 0.7 2.3 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Integrin_alpha PF00357.20 EDK37086.2 - 9.1 6.5 7.9 2.1 8.5 0.6 2.8 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region STD1 PF17235.2 EDK37087.2 - 7.1e-55 185.8 7.2 7.1e-55 185.8 7.2 1.6 1 1 1 2 2 2 1 STD1/MTH1 Frankia_peptide PF14407.6 EDK37087.2 - 0.15 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. RHH_6 PF16762.5 EDK37087.2 - 0.15 12.7 0.0 0.32 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix domain NUP214 PF16755.5 EDK37088.2 - 1.4e-08 34.4 5.7 1.8e-07 30.8 5.7 2.3 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 SlyX PF04102.12 EDK37088.2 - 0.014 16.0 3.2 0.73 10.5 0.2 3.1 2 0 0 2 2 2 0 SlyX GHL13 PF14883.6 EDK37088.2 - 0.13 11.3 2.3 0.78 8.7 2.3 2.1 1 1 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 DUF948 PF06103.11 EDK37088.2 - 0.37 11.1 3.2 0.7 10.2 0.9 2.5 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EDK37088.2 - 0.42 10.8 6.9 0.51 10.5 4.9 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 EDK37088.2 - 2.6 8.6 7.1 1.3 9.5 0.2 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1319 PF07028.11 EDK37088.2 - 4.1 7.7 8.5 1.7 8.9 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1319) CAP_GLY PF01302.25 EDK37089.2 - 4.3e-13 49.1 0.4 7.8e-13 48.2 0.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain FAM76 PF16046.5 EDK37089.2 - 0.00039 19.9 9.5 0.00039 19.9 9.5 2.1 1 1 1 2 2 2 1 FAM76 protein DUF745 PF05335.13 EDK37089.2 - 0.0022 17.7 11.3 0.0022 17.7 11.3 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF745) VSG_B PF13206.6 EDK37089.2 - 0.007 15.7 11.9 0.016 14.5 11.9 1.5 2 0 0 2 2 2 1 Trypanosomal VSG domain MPS2 PF17060.5 EDK37089.2 - 0.02 14.2 20.1 0.075 12.3 20.1 1.7 1 1 0 1 1 1 0 Monopolar spindle protein 2 EzrA PF06160.12 EDK37089.2 - 0.07 11.3 26.7 0.0077 14.5 9.9 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 EDK37089.2 - 0.13 12.8 3.6 4.8 7.7 1.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CLIP1_ZNF PF16641.5 EDK37089.2 - 0.14 12.1 1.2 0.27 11.2 1.2 1.4 1 0 0 1 1 1 0 CLIP1 zinc knuckle zf-CCHC PF00098.23 EDK37089.2 - 0.21 11.7 1.7 0.42 10.8 1.7 1.5 1 0 0 1 1 1 0 Zinc knuckle Matrilin_ccoil PF10393.9 EDK37089.2 - 0.31 10.9 4.1 1.4 8.8 2.1 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin SlyX PF04102.12 EDK37089.2 - 0.53 10.9 15.0 0.44 11.2 1.3 2.8 2 1 0 2 2 2 0 SlyX Lebercilin PF15619.6 EDK37089.2 - 0.63 9.7 32.4 1.2 8.8 32.3 1.4 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Tropomyosin_1 PF12718.7 EDK37089.2 - 0.92 9.7 32.3 1.3 9.1 13.9 2.4 1 1 1 2 2 2 0 Tropomyosin like LMBR1 PF04791.16 EDK37089.2 - 0.97 8.3 12.8 1.2 7.9 12.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Mit_KHE1 PF10173.9 EDK37089.2 - 1.2 9.1 6.7 2.1 8.4 6.7 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF787 PF05619.11 EDK37089.2 - 1.4 8.0 5.8 0.17 11.0 0.8 1.8 1 1 1 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF787) FAM184 PF15665.5 EDK37089.2 - 1.9 8.2 29.9 4.1 7.1 29.9 1.5 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B PilJ PF13675.6 EDK37089.2 - 2 8.5 10.5 2.3 8.3 0.9 2.5 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term PspB PF06667.12 EDK37089.2 - 2.7 8.1 9.6 0.094 12.8 1.8 2.3 2 0 0 2 2 2 0 Phage shock protein B DHR10 PF18595.1 EDK37089.2 - 4.3 7.4 28.2 1.8 8.6 11.7 2.4 1 1 0 2 2 2 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 EDK37089.2 - 5.2 7.5 11.4 1.8 9.0 1.4 3.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EDK37089.2 - 8.7 6.4 8.7 8.8 6.4 2.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PhzC-PhzF PF02567.16 EDK37090.2 - 9.1e-66 222.2 0.0 1e-65 222.0 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 EDK37090.2 - 9.1e-07 28.2 0.0 2.1e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Proline racemase Homeodomain PF00046.29 EDK37090.2 - 0.21 11.4 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Homeodomain FMN_dh PF01070.18 EDK37091.2 - 3.1e-92 309.3 0.0 4.3e-92 308.8 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDK37091.2 - 9.2e-21 73.8 0.1 2.9e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDK37091.2 - 0.00018 20.8 0.0 0.00028 20.1 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Git3 PF11710.8 EDK37092.2 - 6.1e-74 248.2 17.8 7.3e-74 247.9 17.8 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 TauD PF02668.16 EDK37093.2 - 9.4e-60 202.7 0.3 1.4e-59 202.1 0.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sulfatase PF00884.23 EDK37094.1 - 1.3e-64 218.6 0.0 2.1e-64 217.9 0.0 1.3 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EDK37094.1 - 0.0021 16.8 0.0 0.003 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4994 PF16385.5 EDK37094.1 - 0.0073 16.2 0.0 0.023 14.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 EDK37094.1 - 0.02 15.7 0.0 0.18 12.5 0.0 2.4 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase DUF4976 PF16347.5 EDK37094.1 - 0.088 13.1 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) ACOX PF01756.19 EDK37095.2 - 5.6e-43 146.6 0.1 1.6e-42 145.1 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EDK37095.2 - 2.2e-23 82.3 0.1 3.7e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EDK37095.2 - 6e-16 59.1 0.1 1.4e-15 58.0 0.1 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EDK37095.2 - 0.0011 19.1 0.1 0.0053 17.0 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain TBCC_N PF16752.5 EDK37095.2 - 8.7 6.8 7.1 1.3 9.5 1.1 2.6 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain SUR7 PF06687.12 EDK37096.2 - 6.6e-08 32.4 5.0 1.1e-07 31.8 5.0 1.3 1 0 0 1 1 1 1 SUR7/PalI family ATAD4 PF15321.6 EDK37096.2 - 0.058 14.7 0.2 0.24 12.7 0.0 2.1 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Fig1 PF12351.8 EDK37096.2 - 0.2 11.6 6.6 0.13 12.1 3.9 2.0 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Pox_EPC_I2-L1 PF12575.8 EDK37096.2 - 0.26 11.5 3.0 13 6.0 0.1 2.7 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 DUF4389 PF14333.6 EDK37096.2 - 5 7.1 0.0 5 7.1 0.0 3.5 4 1 0 4 4 4 0 Domain of unknown function (DUF4389) adh_short PF00106.25 EDK37097.2 - 1.6e-22 79.9 0.0 8.9e-19 67.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDK37097.2 - 1.6e-15 57.3 0.0 5.1e-13 49.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK37097.2 - 2.8e-09 37.1 0.0 3.8e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK37097.2 - 4.1e-07 29.7 0.0 6.3e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDK37097.2 - 0.00031 20.7 0.1 0.001 19.0 0.0 1.9 2 1 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EDK37097.2 - 0.0011 18.5 0.5 0.0077 15.7 0.0 2.3 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase NAD_binding_7 PF13241.6 EDK37097.2 - 0.0092 16.4 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EDK37097.2 - 0.02 14.9 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NmrA PF05368.13 EDK37097.2 - 0.054 13.0 0.1 0.087 12.4 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.15 EDK37097.2 - 0.078 12.1 0.1 0.11 11.6 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Fungal_trans_2 PF11951.8 EDK37098.2 - 3.2e-49 167.8 2.8 4.2e-49 167.4 2.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37098.2 - 5.6e-07 29.6 10.8 1.2e-06 28.5 10.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 EDK37099.2 - 7.8e-74 249.0 37.7 9e-74 248.8 37.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MatE PF01554.18 EDK37100.2 - 2.2e-50 170.5 36.3 5.9e-30 104.1 10.8 2.8 3 0 0 3 3 3 2 MatE DUF4870 PF09685.10 EDK37100.2 - 0.033 14.3 2.0 0.033 14.3 2.0 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF4870) Arginase PF00491.21 EDK37101.2 - 3.9e-35 121.7 0.0 5.2e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EDK37101.2 - 0.11 12.8 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 UPF0489 domain Arginase PF00491.21 EDK37102.2 - 1.3e-40 139.7 0.0 1.6e-40 139.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family Hyphal_reg_CWP PF11765.8 EDK37104.2 - 6.3e-110 367.2 14.1 1.4e-109 366.1 14.1 1.6 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.6 EDK37104.2 - 8.6e-10 39.0 20.5 8.6e-10 39.0 20.5 15.9 12 3 2 14 14 14 1 Flocculin type 3 repeat DUF3039 PF11238.8 EDK37104.2 - 0.28 11.0 33.8 16 5.4 0.0 9.4 10 0 0 10 10 10 0 Protein of unknown function (DUF3039) Zn_Tnp_IS1595 PF12760.7 EDK37104.2 - 0.55 10.3 28.1 30 4.7 0.1 8.9 9 0 0 9 9 9 0 Transposase zinc-ribbon domain zf-RRN7 PF11781.8 EDK37104.2 - 0.89 9.3 30.8 56 3.5 0.0 9.1 10 0 0 10 10 10 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Fer4_11 PF13247.6 EDK37104.2 - 2.1 8.5 21.7 52 4.1 0.1 8.2 2 2 8 10 10 10 0 4Fe-4S dicluster domain DUF4964 PF16334.5 EDK37105.2 - 0.037 13.6 0.1 0.085 12.4 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4964) LRR_4 PF12799.7 EDK37106.2 - 0.004 17.5 0.2 0.11 13.0 0.0 2.8 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EDK37107.2 - 0.13 12.1 0.7 0.52 10.2 0.2 2.3 2 0 0 2 2 2 0 F-box-like LRR_8 PF13855.6 EDK37107.2 - 6.5 6.6 13.4 0.4 10.5 2.0 4.5 5 1 0 5 5 5 0 Leucine rich repeat LRR_4 PF12799.7 EDK37108.2 - 1.8e-06 28.1 22.3 0.0045 17.4 0.1 8.4 6 3 7 13 13 13 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK37108.2 - 0.00011 21.9 16.3 0.62 9.9 0.0 6.9 5 2 2 8 8 8 4 Leucine rich repeat LRR_6 PF13516.6 EDK37108.2 - 0.0004 20.2 5.6 46 4.4 0.0 8.0 10 0 0 10 10 10 0 Leucine Rich repeat FNIP PF05725.12 EDK37108.2 - 0.0028 17.8 12.2 0.36 11.0 0.0 5.6 6 0 0 6 6 6 2 FNIP Repeat LRR_1 PF00560.33 EDK37108.2 - 0.89 10.3 21.8 16 6.5 0.0 8.6 8 2 0 8 8 8 0 Leucine Rich Repeat ATG22 PF11700.8 EDK37109.2 - 1.3e-137 459.3 26.1 1.5e-137 459.1 26.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EDK37110.2 - 2.3e-40 138.6 31.8 2.3e-40 138.6 31.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK37110.2 - 2.5e-18 66.2 5.4 2.5e-18 66.2 5.4 2.3 1 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EDK37110.2 - 0.0024 16.4 1.4 0.0024 16.4 1.4 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) PsbI PF02532.14 EDK37110.2 - 5.6 7.0 9.9 1.5 8.8 0.2 3.8 4 0 0 4 4 4 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) OPT PF03169.15 EDK37111.2 - 3.2e-168 561.2 42.3 3.6e-168 561.0 42.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.6 EDK37111.2 - 0.34 11.2 0.1 0.34 11.2 0.1 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF4064) Saf_2TM PF18303.1 EDK37112.2 - 0.019 14.5 5.5 0.048 13.3 0.1 2.3 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Cation_ATPase_C PF00689.21 EDK37112.2 - 2.1 8.0 13.9 1.3 8.7 2.8 2.2 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus COX2_TM PF02790.15 EDK37112.2 - 5.6 7.2 6.7 11 6.3 1.8 2.7 2 1 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain FMO-like PF00743.19 EDK37114.2 - 1.6e-32 112.7 0.3 6.8e-17 61.1 0.0 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDK37114.2 - 1.1e-10 41.3 0.6 3.3e-05 23.3 0.4 3.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK37114.2 - 7.6e-08 31.9 0.5 5.4e-06 25.8 0.1 2.7 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EDK37114.2 - 9.2e-08 31.7 0.0 1.9e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK37114.2 - 4.9e-06 26.6 0.0 7.7e-05 22.7 0.0 2.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EDK37114.2 - 1.3e-05 25.3 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDK37114.2 - 0.0037 16.9 0.1 0.48 10.0 0.0 2.8 2 1 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 EDK37114.2 - 0.0066 15.7 0.0 0.025 13.8 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EDK37114.2 - 0.0088 16.6 0.1 0.062 13.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDK37114.2 - 0.12 11.0 0.1 0.42 9.3 0.2 1.7 2 0 0 2 2 2 0 HI0933-like protein MFS_1 PF07690.16 EDK37115.2 - 6e-20 71.5 30.4 6e-20 71.5 30.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4381 PF14316.6 EDK37115.2 - 3 8.1 4.3 7 6.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Hyphal_reg_CWP PF11765.8 EDK37116.2 - 6.7e-112 373.6 10.3 8.6e-112 373.3 10.3 1.0 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Sugar_tr PF00083.24 EDK37117.1 - 1e-96 324.6 26.6 1.2e-96 324.4 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37117.1 - 1.3e-23 83.5 52.9 9.2e-20 70.9 27.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM51 PF15345.6 EDK37117.1 - 0.069 13.0 0.7 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 Fungal_trans_2 PF11951.8 EDK37118.2 - 2.6e-19 69.3 3.3 8.2e-19 67.7 3.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37118.2 - 9.2e-07 28.9 11.4 1.6e-06 28.1 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transketolase_N PF00456.21 EDK37119.2 - 1.1e-124 415.7 0.0 1.8e-124 415.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDK37119.2 - 3e-42 144.3 0.0 5e-42 143.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 EDK37119.2 - 3.7e-08 32.9 0.0 3.6e-06 26.4 0.0 2.3 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 EDK37119.2 - 3.7e-06 26.8 0.0 9.5e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 EDK37119.2 - 0.0012 17.9 0.0 0.0021 17.1 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EDK37119.2 - 0.0059 16.4 0.2 0.084 12.7 0.1 3.0 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain ADH_N PF08240.12 EDK37120.2 - 1.3e-30 105.5 1.8 2.2e-30 104.7 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK37120.2 - 3.7e-14 52.8 0.0 6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK37120.2 - 8.1e-08 32.0 0.0 6.7e-07 29.0 0.0 2.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDK37120.2 - 0.0017 19.4 0.0 0.0037 18.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Hyphal_reg_CWP PF11765.8 EDK37121.2 - 2.7e-113 378.2 12.0 7.6e-113 376.8 12.0 1.8 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Hyr1 PF15789.5 EDK37121.2 - 1.3e-13 50.2 169.8 0.033 13.7 8.9 12.4 11 0 0 11 11 11 10 Hyphally regulated cell wall GPI-anchored protein 1 Flocculin_t3 PF13928.6 EDK37121.2 - 4.5e-11 43.1 20.0 4.5e-11 43.1 20.0 15.7 7 3 5 12 12 12 1 Flocculin type 3 repeat FTP PF07504.13 EDK37121.2 - 3.4e-07 30.0 25.1 16 5.4 0.1 10.9 10 0 0 10 10 10 5 Fungalysin/Thermolysin Propeptide Motif Reg_prop PF07494.11 EDK37121.2 - 0.29 11.5 1.7 14 6.3 0.1 4.4 3 0 0 3 3 3 0 Two component regulator propeller PTR2 PF00854.21 EDK37122.1 - 2.3e-95 319.7 16.0 3e-95 319.4 13.8 2.1 1 1 1 2 2 2 1 POT family SUR7 PF06687.12 EDK37123.2 - 0.002 17.8 2.8 0.012 15.2 2.8 2.1 1 1 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EDK37123.2 - 2.2 8.2 11.0 0.052 13.5 2.7 2.4 3 0 0 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 Fig1 PF12351.8 EDK37124.2 - 0.00039 20.4 4.6 0.00039 20.4 4.6 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF2207 PF09972.9 EDK37124.2 - 0.45 9.2 2.9 1.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Sigma_M_inh PF17453.2 EDK37124.2 - 0.76 10.3 6.1 5.6 7.5 2.7 2.4 2 0 0 2 2 2 0 Sigma-M inhibitor DUF973 PF06157.11 EDK37124.2 - 2.2 7.3 10.4 0.21 10.6 4.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF973) Pcc1 PF09341.10 EDK37125.1 - 3.2e-17 62.4 0.1 3.5e-17 62.3 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 Methyltransf_28 PF02636.17 EDK37127.2 - 8.7e-38 130.4 0.0 1.1e-37 130.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MFS_1 PF07690.16 EDK37128.2 - 2.4e-05 23.4 2.5 3.2e-05 23.0 2.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily XRN_M PF17846.1 EDK37129.2 - 4.7e-136 454.3 0.5 4.7e-136 454.3 0.5 1.9 3 0 0 3 3 3 1 Xrn1 helical domain XRN_N PF03159.18 EDK37129.2 - 2.6e-75 253.0 1.0 4.2e-75 252.3 0.0 1.9 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus DAGK_cat PF00781.24 EDK37130.2 - 3.9e-12 45.9 0.0 6.4e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Nup192 PF11894.8 EDK37131.2 - 0 1569.8 61.0 0 1569.6 61.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Rsa3 PF14615.6 EDK37131.2 - 0.055 13.1 0.9 13 5.5 0.0 3.4 2 0 0 2 2 2 0 Ribosome-assembly protein 3 PB1 PF00564.24 EDK37131.2 - 0.076 13.0 0.0 66 3.5 0.0 3.5 3 0 0 3 3 3 0 PB1 domain SnoaL_4 PF13577.6 EDK37132.2 - 4e-22 78.7 0.0 4.6e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain AA_permease PF00324.21 EDK37133.1 - 1e-106 357.4 38.8 1.2e-106 357.1 38.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK37133.1 - 2.7e-15 56.2 40.9 3.8e-15 55.7 40.9 1.2 1 0 0 1 1 1 1 Amino acid permease PIN_4 PF13638.6 EDK37134.2 - 8.4e-15 55.2 0.0 1.5e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 PIN domain PIN_12 PF16289.5 EDK37134.2 - 0.01 16.3 0.1 0.044 14.3 0.1 2.0 1 1 0 1 1 1 0 PIN domain Ribosomal_L40e PF01020.17 EDK37136.1 - 9.2e-32 108.7 11.4 1e-31 108.6 11.4 1.0 1 0 0 1 1 1 1 Ribosomal L40e family Spc7 PF08317.11 EDK37137.2 - 0.00037 19.5 13.0 0.00056 18.9 13.0 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4055 PF13264.6 EDK37137.2 - 0.1 12.7 2.1 0.21 11.8 1.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4055) Cob_adeno_trans PF01923.18 EDK37137.2 - 0.22 11.6 4.0 0.39 10.8 4.0 1.4 1 0 0 1 1 1 0 Cobalamin adenosyltransferase MelC1 PF06236.11 EDK37137.2 - 0.75 9.9 2.5 9.4 6.4 0.0 2.7 3 0 0 3 3 3 0 Tyrosinase co-factor MelC1 CENP-F_leu_zip PF10473.9 EDK37137.2 - 0.93 9.5 19.8 1.1 9.3 18.3 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 EDK37137.2 - 1.3 8.3 10.6 2.3 7.5 10.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EDK37137.2 - 2.8 8.6 20.1 0.63 10.7 5.5 3.5 2 1 1 3 3 3 0 SlyX Rho_Binding PF08912.11 EDK37137.2 - 3.5 8.5 13.0 1.1 10.2 1.7 2.7 2 0 0 2 2 2 0 Rho Binding TPR_MLP1_2 PF07926.12 EDK37138.2 - 9.7e-09 35.4 21.5 9.7e-09 35.4 21.5 14.9 4 4 7 13 13 13 3 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EDK37138.2 - 0.003 17.6 16.9 0.003 17.6 16.9 12.0 4 1 9 13 13 13 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CCDC144C PF14915.6 EDK37138.2 - 0.0046 16.1 19.3 0.0046 16.1 19.3 9.7 1 1 6 8 8 8 2 CCDC144C protein coiled-coil region Tropomyosin_1 PF12718.7 EDK37138.2 - 0.0083 16.3 16.8 0.0083 16.3 16.8 13.6 4 4 8 13 13 13 1 Tropomyosin like DUF4041 PF13250.6 EDK37138.2 - 0.58 10.1 7.4 29 4.6 0.2 5.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) Sugar_tr PF00083.24 EDK37139.2 - 2.9e-83 280.2 20.8 3.6e-83 279.9 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37139.2 - 1.3e-16 60.5 22.0 4e-15 55.6 18.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1634 PF07843.11 EDK37139.2 - 0.53 10.4 4.5 0.39 10.8 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1634) p450 PF00067.22 EDK37140.2 - 4.1e-64 217.0 0.0 4.9e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PEPCK_ATP PF01293.20 EDK37141.2 - 3.5e-216 718.4 0.0 4.1e-216 718.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EDK37141.2 - 0.14 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EDK37142.2 - 2.5e-15 56.3 29.9 2.5e-15 56.3 29.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDK37142.2 - 1.7e-10 40.9 9.3 1.7e-10 40.9 9.3 2.8 5 0 0 5 5 5 1 Ion channel regulatory protein UNC-93 DUF3493 PF11998.8 EDK37142.2 - 0.13 12.5 0.6 0.88 9.8 0.8 2.4 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 MotA_ExbB PF01618.16 EDK37142.2 - 6.7 6.5 6.3 8.7 6.1 0.5 2.9 3 0 0 3 3 3 0 MotA/TolQ/ExbB proton channel family Glyco_hydro_3 PF00933.21 EDK37143.2 - 7.7e-57 193.1 0.0 1e-56 192.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain XPG_I PF00867.18 EDK37144.2 - 3.2e-28 97.9 0.0 1.7e-27 95.6 0.0 2.2 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 EDK37144.2 - 2.1e-05 24.1 0.0 3.8e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 EDK37144.2 - 0.0006 20.2 0.0 0.0018 18.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain PTPA PF03095.15 EDK37145.2 - 2.9e-100 335.6 0.0 3.4e-100 335.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein zf-RING_2 PF13639.6 EDK37146.2 - 4.9e-07 30.0 9.0 4.9e-07 30.0 9.0 2.0 2 0 0 2 2 1 1 Ring finger domain FANCL_C PF11793.8 EDK37146.2 - 1.3e-06 28.5 5.8 4.6e-06 26.7 5.8 2.0 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 EDK37146.2 - 0.0001 22.5 6.8 0.00031 21.0 6.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDK37146.2 - 0.00013 21.9 2.0 0.00045 20.2 2.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EDK37146.2 - 0.004 17.0 9.6 0.01 15.7 9.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Post_transc_reg PF13797.6 EDK37146.2 - 0.034 14.0 0.1 2 8.3 0.0 2.6 2 0 0 2 2 2 0 Post-transcriptional regulator RINGv PF12906.7 EDK37146.2 - 0.052 13.7 7.5 0.13 12.4 7.5 1.8 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_2 PF13923.6 EDK37146.2 - 0.092 12.6 8.9 0.28 11.0 8.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDK37146.2 - 0.15 11.7 6.8 0.4 10.3 6.8 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF2256 PF10013.9 EDK37146.2 - 0.4 10.8 2.3 4.1 7.6 0.4 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-RING-like PF08746.11 EDK37146.2 - 0.42 11.0 10.9 0.36 11.2 8.1 2.3 2 0 0 2 2 2 0 RING-like domain PHD PF00628.29 EDK37146.2 - 0.97 9.4 7.2 2.5 8.1 7.2 1.8 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 EDK37146.2 - 2.6 8.0 10.5 2.3 8.2 6.6 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_3 PF13920.6 EDK37146.2 - 2.6 8.0 5.5 9.2 6.2 5.5 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 EDK37146.2 - 3.2 7.9 5.0 7.2 6.8 3.0 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING_4 PF14570.6 EDK37146.2 - 4.3 7.2 5.5 33 4.4 5.4 2.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Herpes_Helicase PF02689.14 EDK37147.2 - 2.5e-06 25.8 0.0 3.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 EDK37147.2 - 0.0026 17.5 0.2 0.02 14.7 0.2 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain PIF1 PF05970.14 EDK37147.2 - 0.0033 16.6 0.2 0.0047 16.2 0.2 1.2 1 0 0 1 1 1 1 PIF1-like helicase SH3_13 PF18335.1 EDK37147.2 - 0.079 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain PIF1 PF05970.14 EDK37148.2 - 3.5e-46 158.0 1.4 3.6e-41 141.6 0.2 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EDK37148.2 - 3.7e-23 82.2 0.0 5e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK37148.2 - 1.9e-06 28.3 0.0 3.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDK37148.2 - 0.00039 20.0 0.1 0.001 18.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EDK37148.2 - 0.0012 19.2 0.0 0.003 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDK37148.2 - 0.0027 17.0 0.1 0.011 15.0 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EDK37148.2 - 0.0038 17.7 0.0 0.0076 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 EDK37148.2 - 0.021 15.0 0.2 4.5 7.4 0.1 2.9 3 0 0 3 3 3 0 Torsin AAA_5 PF07728.14 EDK37148.2 - 0.035 14.1 0.1 0.086 12.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDK37148.2 - 0.12 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EDK37148.2 - 0.12 12.7 0.0 0.49 10.8 0.0 2.1 1 1 0 1 1 1 0 RNA helicase FH2 PF02181.23 EDK37149.2 - 7.4e-83 278.7 5.9 2e-82 277.3 5.9 1.7 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EDK37149.2 - 2.1e-15 56.8 5.3 2.1e-15 56.8 5.3 4.3 4 2 0 4 4 4 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EDK37149.2 - 2e-10 40.6 0.3 2e-10 40.6 0.3 2.5 2 0 0 2 2 2 1 Diaphanous FH3 Domain Adaptin_binding PF10199.9 EDK37149.2 - 0.026 15.1 7.6 0.27 11.8 7.6 2.9 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF4817 PF16087.5 EDK37149.2 - 0.2 11.5 0.5 13 5.7 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) FTHFS PF01268.19 EDK37150.2 - 2.9e-244 811.4 0.4 3.7e-244 811.1 0.4 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDK37150.2 - 1.9e-65 219.1 3.5 3.9e-65 218.0 1.5 2.5 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDK37150.2 - 5.1e-35 120.3 0.2 1.1e-34 119.2 0.2 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SUB1_ProdP9 PF18213.1 EDK37150.2 - 0.032 14.1 0.2 0.21 11.4 0.0 2.2 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 NAD_binding_10 PF13460.6 EDK37151.2 - 5.2e-38 130.8 1.4 6e-38 130.6 1.4 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDK37151.2 - 1.3e-06 28.2 4.1 4.3e-05 23.2 4.1 2.0 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EDK37151.2 - 4.2e-06 26.4 0.1 4.5e-05 23.0 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EDK37151.2 - 2.1e-05 24.8 0.2 4.3e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EDK37151.2 - 0.00043 20.7 0.2 0.0011 19.4 0.2 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDK37151.2 - 0.00075 19.6 0.1 0.0015 18.7 0.1 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 EDK37151.2 - 0.00092 18.3 0.5 0.0016 17.5 0.5 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK37151.2 - 0.0038 16.4 0.0 0.027 13.6 0.0 2.2 1 1 1 2 2 2 1 Male sterility protein EPL1 PF10513.9 EDK37153.2 - 6.6e-34 117.6 4.2 6.6e-34 117.6 4.2 2.1 2 0 0 2 2 2 1 Enhancer of polycomb-like Phage_Gp111 PF07410.11 EDK37153.2 - 0.072 13.6 0.3 0.072 13.6 0.3 1.8 2 0 0 2 2 2 0 Streptococcus thermophilus bacteriophage Gp111 protein WD40 PF00400.32 EDK37154.2 - 6.4e-08 33.1 7.5 0.051 14.5 0.1 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Pkinase PF00069.25 EDK37155.2 - 4.1e-51 173.9 0.1 9.5e-51 172.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37155.2 - 3.8e-20 72.3 0.0 7e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK37155.2 - 0.016 14.2 0.4 0.062 12.2 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EDK37155.2 - 0.14 12.1 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Aminotran_1_2 PF00155.21 EDK37156.1 - 4.9e-40 137.8 0.0 6e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDK37156.1 - 0.00051 18.7 0.0 0.00074 18.2 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 EDK37156.1 - 0.0019 17.1 0.0 0.0032 16.4 0.0 1.3 1 0 0 1 1 1 1 Allinase Beta_elim_lyase PF01212.21 EDK37156.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 EDK37156.1 - 0.028 13.4 0.0 0.065 12.2 0.0 1.6 1 0 0 1 1 1 0 Aminotransferase class-V NDT80_PhoG PF05224.12 EDK37157.2 - 2.9e-35 122.2 0.1 2.9e-35 122.2 0.1 2.0 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family SDA1 PF05285.12 EDK37157.2 - 0.24 10.8 7.1 0.47 9.8 7.1 1.4 1 0 0 1 1 1 0 SDA1 Thiolase_N PF00108.23 EDK37158.1 - 6.8e-84 281.3 2.8 1.2e-83 280.5 2.8 1.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDK37158.1 - 2.7e-47 159.4 0.2 4.7e-47 158.7 0.2 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDK37158.1 - 6e-06 26.0 1.9 4.4e-05 23.2 0.5 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EDK37158.1 - 0.076 13.2 0.0 0.25 11.5 0.0 2.0 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GSH_synth_ATP PF03917.17 EDK37159.2 - 0.13 11.0 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain CCDC53 PF10152.9 EDK37160.2 - 8.2 6.8 11.7 17 5.8 4.1 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Cbl_N2 PF02761.14 EDK37161.2 - 0.15 12.8 0.5 0.59 10.9 0.2 2.1 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain ADH_N PF08240.12 EDK37163.2 - 2.6e-28 98.1 0.9 4.1e-28 97.4 0.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK37163.2 - 8.2e-18 64.6 0.0 1.5e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK37163.2 - 2.9e-05 23.6 0.0 4.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 EDK37163.2 - 4.2e-05 23.4 0.0 0.00011 22.0 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated 2-Hacid_dh_C PF02826.19 EDK37163.2 - 0.007 15.7 0.0 0.014 14.7 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDK37163.2 - 0.029 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_25 PF13649.6 EDK37163.2 - 0.057 14.1 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ThiF PF00899.21 EDK37163.2 - 0.086 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 ThiF family PAC2 PF09754.9 EDK37163.2 - 0.1 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 PAC2 family ADH_zinc_N_2 PF13602.6 EDK37163.2 - 0.11 13.5 0.0 0.2 12.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 EDK37163.2 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Cyclin_N PF00134.23 EDK37166.2 - 7.9e-11 41.8 0.2 1.6e-10 40.8 0.2 1.5 1 1 0 1 1 1 1 Cyclin, N-terminal domain MFS_1 PF07690.16 EDK37167.2 - 1.1e-40 139.7 48.9 1.9e-40 138.9 46.1 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK37167.2 - 2e-13 49.7 26.0 2.8e-13 49.2 26.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK37167.2 - 4.9e-07 29.0 17.9 4.9e-07 29.0 17.9 3.0 1 1 0 3 3 3 1 Sugar (and other) transporter DUF4149 PF13664.6 EDK37167.2 - 0.018 15.4 3.2 0.018 15.4 3.2 4.6 6 1 0 6 6 6 0 Domain of unknown function (DUF4149) Pox_A14 PF05767.12 EDK37167.2 - 0.049 13.8 0.9 0.28 11.4 0.9 2.4 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 JAB PF01398.21 EDK37168.2 - 1.1e-12 48.0 0.0 1.9e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDK37168.2 - 0.00057 20.3 0.6 0.00099 19.5 0.6 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function CRF1 PF10380.9 EDK37169.2 - 4.5e-24 85.0 0.8 4.5e-24 85.0 0.8 3.5 3 0 0 3 3 3 1 Transcription factor CRF1 TFIIS_M PF07500.14 EDK37170.2 - 4.2e-11 43.3 0.0 1.2e-10 41.9 0.0 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EDK37170.2 - 3.4e-09 36.5 9.3 7.3e-09 35.4 9.3 1.6 1 0 0 1 1 1 1 PHD-finger SPOC PF07744.13 EDK37170.2 - 4.3e-07 30.0 0.0 2.1e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 SPOC domain PHD_2 PF13831.6 EDK37170.2 - 0.0067 16.0 4.3 0.014 14.9 4.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EDK37170.2 - 0.62 10.2 11.5 0.4 10.8 4.6 2.8 1 1 1 2 2 2 0 PHD-finger zf-CW PF07496.15 EDK37170.2 - 1.4 9.0 6.3 3.5 7.7 6.3 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger C1_1 PF00130.22 EDK37170.2 - 1.4 8.8 6.3 0.33 10.9 1.2 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SDA1 PF05285.12 EDK37170.2 - 8.6 5.7 46.8 3.7 6.9 17.7 2.2 2 0 0 2 2 2 0 SDA1 Rad9_Rad53_bind PF08605.10 EDK37171.2 - 2.8e-24 85.8 0.0 6.6e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 EDK37171.2 - 3.4e-10 40.2 0.2 9.1e-08 32.4 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDK37171.2 - 9.4e-05 22.7 0.4 0.0048 17.3 0.0 3.0 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EDK37171.2 - 0.0043 17.1 0.0 0.026 14.6 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Pro_dh PF01619.18 EDK37172.1 - 2e-61 208.2 0.0 2.6e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase SLS PF14611.6 EDK37173.2 - 2.5e-24 86.4 0.0 4.9e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator DUF775 PF05603.12 EDK37173.2 - 0.0007 19.2 0.5 0.035 13.6 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF775) CobW_C PF07683.14 EDK37173.2 - 0.057 13.3 0.0 5.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain ABC1 PF03109.16 EDK37174.2 - 1.4e-22 80.0 0.2 2.9e-22 79.1 0.2 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 EDK37174.2 - 0.041 13.8 0.1 0.22 11.4 0.1 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family Utp13 PF08625.11 EDK37175.2 - 4.4e-43 146.6 0.0 6.7e-43 146.0 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 EDK37175.2 - 1.8e-40 136.2 34.0 5.8e-06 27.0 0.0 11.9 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37175.2 - 4.2e-12 46.2 4.7 0.2 11.9 0.0 6.9 6 2 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDK37175.2 - 1.2e-05 24.0 1.2 0.04 12.5 0.2 3.6 3 0 0 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EDK37175.2 - 7.6e-05 21.8 8.7 0.46 9.4 0.1 4.9 3 2 3 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDK37175.2 - 7.9e-05 21.5 4.2 4.9 5.7 0.2 5.8 4 1 1 6 6 6 1 Nucleoporin Nup120/160 WD40_like PF17005.5 EDK37175.2 - 0.0031 16.9 1.3 0.18 11.1 0.0 3.7 5 0 0 5 5 5 1 WD40-like domain BBS2_Mid PF14783.6 EDK37175.2 - 0.0035 17.4 0.3 22 5.1 0.0 5.8 6 2 0 7 7 7 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EDK37175.2 - 0.037 13.9 0.5 3.8 7.3 0.0 3.9 2 2 2 4 4 4 0 Eukaryotic translation initiation factor eIF2A Lectin_C PF00059.21 EDK37175.2 - 3.3 8.5 6.0 44 4.9 0.0 3.9 4 0 0 4 4 4 0 Lectin C-type domain Zn_clus PF00172.18 EDK37176.2 - 4.9e-07 29.8 18.5 9.5e-07 28.8 18.5 1.5 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EDK37177.2 - 0.018 14.9 0.1 0.072 13.0 0.0 2.1 2 0 0 2 2 2 0 F-box-like MSC PF09402.10 EDK37178.2 - 1.4e-99 333.8 0.1 1.4e-99 333.8 0.1 1.7 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain PBP1_TM PF14812.6 EDK37178.2 - 0.011 16.1 0.0 0.011 16.1 0.0 3.3 2 2 2 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2630 PF10944.8 EDK37178.2 - 0.066 13.7 2.3 0.7 10.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) RWD PF05773.22 EDK37179.2 - 3.7e-23 82.0 0.8 3.7e-23 82.0 0.8 1.9 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EDK37179.2 - 1.5e-05 25.3 3.5 1.5e-05 25.3 3.5 2.0 2 1 0 2 2 2 1 DRG Family Regulatory Proteins, Tma46 SH3_1 PF00018.28 EDK37180.2 - 6.2e-10 38.5 1.0 2.3e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDK37180.2 - 6.5e-09 35.5 2.5 6.8e-09 35.5 0.2 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EDK37180.2 - 2e-05 24.2 0.1 3.3e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2309 PF10070.9 EDK37181.2 - 0.00084 17.8 1.0 0.0032 15.9 0.4 1.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2309) AF-4 PF05110.13 EDK37181.2 - 5.2 5.0 18.9 7.6 4.5 18.9 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein ADH_N PF08240.12 EDK37183.1 - 1.4e-28 98.9 0.1 2.7e-28 98.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK37183.1 - 1.6e-28 99.2 1.4 2.6e-28 98.6 1.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDK37183.1 - 1.7e-05 25.9 0.0 3.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EDK37183.1 - 0.012 15.1 0.1 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glu_dehyd_C PF16912.5 EDK37183.1 - 0.11 11.9 0.3 0.16 11.4 0.3 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Transketolase_N PF00456.21 EDK37184.1 - 5.5e-156 518.7 0.0 8e-156 518.1 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDK37184.1 - 1.8e-44 151.6 0.0 2.8e-44 150.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDK37184.1 - 1.6e-13 50.6 0.0 3.3e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EDK37184.1 - 0.00067 19.0 0.0 0.0015 17.8 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EDK37184.1 - 0.0075 16.1 0.2 0.074 12.8 0.2 2.3 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Opy2 PF09463.10 EDK37185.2 - 1.2e-06 28.7 18.4 1.8e-06 28.1 18.4 1.3 1 0 0 1 1 1 1 Opy2 protein ASFV_J13L PF05568.11 EDK37185.2 - 0.03 14.1 0.2 0.13 12.0 0.2 1.9 1 1 0 1 1 1 0 African swine fever virus J13L protein zf-ANAPC11 PF12861.7 EDK37185.2 - 0.096 12.7 4.9 0.18 11.8 4.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PepSY_TM PF03929.16 EDK37185.2 - 7.8 6.1 5.6 4.9 6.7 0.2 2.4 3 0 0 3 3 3 0 PepSY-associated TM region Not3 PF04065.15 EDK37186.2 - 1.6e-74 250.2 29.2 2.6e-74 249.6 29.2 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EDK37186.2 - 3.8e-39 133.8 5.4 1.4e-38 131.9 5.4 2.0 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Takusan PF04822.13 EDK37186.2 - 0.5 10.3 11.4 1.1 9.2 4.1 2.8 2 0 0 2 2 2 0 Takusan bZIP_1 PF00170.21 EDK37186.2 - 3.9 7.6 15.2 4.1 7.6 0.2 4.2 4 0 0 4 4 4 0 bZIP transcription factor Snapin_Pallidin PF14712.6 EDK37186.2 - 5.6 7.5 19.0 0.26 11.7 2.7 2.9 2 1 1 3 3 3 0 Snapin/Pallidin DUF1664 PF07889.12 EDK37186.2 - 7.1 6.7 15.7 0.27 11.3 2.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) LMWPc PF01451.21 EDK37187.1 - 5.1e-39 133.9 0.0 6e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Med15_fungi PF05397.12 EDK37188.2 - 1.1e-36 125.6 3.1 1.1e-36 125.6 3.1 4.6 3 1 1 4 4 4 1 Mediator complex subunit 15 Gal11_ABD1 PF18535.1 EDK37188.2 - 1.4e-33 114.8 4.8 1.4e-33 114.8 4.8 4.4 5 0 0 5 5 5 1 Gal11 activator-binding domain (ABD1) KIX_2 PF16987.5 EDK37188.2 - 1.6e-17 63.2 3.2 1.6e-17 63.2 3.2 3.4 3 0 0 3 3 3 1 KIX domain TFIIS_M PF07500.14 EDK37188.2 - 0.029 14.8 0.9 0.029 14.8 0.9 2.8 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS), central domain WD40 PF00400.32 EDK37189.2 - 7e-49 162.8 28.6 1.5e-06 28.8 1.0 11.3 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37189.2 - 6.5e-19 68.0 6.4 0.00041 20.6 0.0 9.5 2 2 8 11 11 11 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EDK37189.2 - 3e-18 66.1 0.3 5.5e-18 65.2 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 EDK37189.2 - 1.6e-09 37.5 0.8 0.00061 19.2 0.0 4.6 3 2 0 4 4 4 3 WD40-like domain Nup160 PF11715.8 EDK37189.2 - 2.3e-09 36.4 4.3 0.0047 15.6 0.2 4.9 3 2 1 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDK37189.2 - 5.1e-05 22.4 4.8 1 8.2 0.1 5.7 2 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EDK37189.2 - 0.0001 22.1 1.0 1.4 8.6 0.1 4.2 3 2 1 4 4 4 2 TUP1-like enhancer of split PALB2_WD40 PF16756.5 EDK37189.2 - 0.00015 20.8 5.6 2 7.3 0.1 5.0 5 0 0 5 5 5 3 Partner and localizer of BRCA2 WD40 domain ELYS-bb PF16687.5 EDK37189.2 - 0.00098 17.8 0.2 0.097 11.3 0.0 3.6 3 1 1 4 4 4 1 beta-propeller of ELYS nucleoporin Pex14_N PF04695.13 EDK37189.2 - 0.017 15.8 3.4 1.2 9.7 0.1 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PLA2_B PF01735.18 EDK37190.2 - 5.8e-196 651.7 3.6 7e-196 651.4 3.6 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain IBR PF01485.21 EDK37190.2 - 0.019 15.2 3.1 0.037 14.2 3.1 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain His_Phos_1 PF00300.22 EDK37191.2 - 6.2e-06 26.0 0.6 1.8e-05 24.5 0.6 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Exo_endo_phos PF03372.23 EDK37192.2 - 3.9e-22 78.9 0.0 9.6e-22 77.6 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 EDK37192.2 - 4.1e-12 46.1 12.0 3.4e-08 33.6 1.1 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK37192.2 - 2e-11 43.4 14.0 5.1e-08 32.5 2.0 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 EDK37192.2 - 0.065 13.3 1.7 2 8.7 0.1 3.2 2 0 0 2 2 2 0 Leucine Rich repeat LRR_9 PF14580.6 EDK37192.2 - 0.2 11.1 1.0 0.55 9.7 1.0 1.6 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EDK37192.2 - 0.6 10.9 13.7 5.1 8.0 0.0 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat HhH-GPD PF00730.25 EDK37193.2 - 4.4e-19 68.9 0.0 1.9e-18 66.9 0.0 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDK37193.2 - 0.00026 20.7 0.0 0.00095 18.9 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif Fungal_trans PF04082.18 EDK37194.2 - 1.8e-33 115.7 0.1 4.4e-33 114.4 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37194.2 - 6.3e-11 42.2 11.6 1.4e-10 41.1 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TonB_N PF16031.5 EDK37194.2 - 2.3 8.7 12.1 0.38 11.3 3.7 2.7 2 0 0 2 2 2 0 TonB polyproline region Methyltransf_11 PF08241.12 EDK37195.1 - 1e-16 61.4 0.0 1.9e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK37195.1 - 1.5e-14 54.5 0.0 2.7e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK37195.1 - 6e-14 52.6 0.1 1.3e-13 51.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK37195.1 - 1.1e-10 41.5 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK37195.1 - 7.9e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK37195.1 - 3e-07 30.0 0.0 6e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EDK37195.1 - 0.0018 17.8 0.0 0.0058 16.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EDK37195.1 - 0.051 12.9 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase PIG-L PF02585.17 EDK37196.2 - 3.3e-23 82.7 0.0 4.5e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Actin PF00022.19 EDK37197.2 - 4.2e-68 229.8 0.0 6e-67 226.0 0.0 1.9 1 1 0 1 1 1 1 Actin LDB19 PF13002.7 EDK37198.2 - 2.4e-62 210.1 0.5 4.3e-62 209.3 0.5 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EDK37198.2 - 3.1e-05 24.0 0.0 0.00012 22.2 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDK37198.2 - 0.0087 16.5 3.7 3.5 8.1 0.0 3.1 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Pkinase PF00069.25 EDK37199.2 - 3e-57 194.0 0.0 4.9e-57 193.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37199.2 - 2.2e-20 73.0 0.0 3.6e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.25 EDK37199.2 - 3.2e-05 23.9 0.0 0.61 10.1 0.0 3.1 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 EDK37199.2 - 0.0002 21.6 0.0 0.33 11.2 0.1 3.5 3 1 0 3 3 3 2 PAS domain Kinase-like PF14531.6 EDK37199.2 - 0.0007 19.0 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDK37199.2 - 0.0038 17.2 0.1 0.011 15.6 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDK37199.2 - 0.028 13.4 0.1 0.028 13.4 0.1 2.6 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EDK37199.2 - 0.043 13.2 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDK37199.2 - 0.1 12.2 0.1 0.37 10.4 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Thiolase_N PF00108.23 EDK37200.2 - 2.1e-81 273.1 1.6 3.3e-81 272.5 1.6 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDK37200.2 - 4.8e-45 152.2 0.6 9.4e-45 151.2 0.6 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDK37200.2 - 0.002 17.7 0.1 0.0049 16.5 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SLD3 PF08639.10 EDK37201.2 - 2.3e-38 132.3 24.1 2.7e-37 128.8 24.1 2.1 1 1 0 1 1 1 1 DNA replication regulator SLD3 TAF6_C PF07571.13 EDK37202.2 - 7.1e-29 100.0 0.1 1.8e-28 98.7 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EDK37202.2 - 1.1e-27 96.0 0.1 3.8e-27 94.3 0.0 2.0 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EDK37202.2 - 7.1e-08 32.9 0.9 2.3e-05 24.7 0.2 2.4 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDK37202.2 - 0.00016 21.9 0.2 0.00016 21.9 0.2 2.2 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDK37202.2 - 0.014 15.4 0.0 0.035 14.2 0.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF348 PF03990.14 EDK37202.2 - 0.13 12.1 0.0 0.41 10.4 0.0 1.9 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain XPG_N PF00752.17 EDK37202.2 - 0.14 12.7 0.1 0.65 10.5 0.0 2.2 3 0 0 3 3 3 0 XPG N-terminal domain SlyX PF04102.12 EDK37203.2 - 0.058 14.0 0.1 0.058 14.0 0.1 2.9 3 0 0 3 3 3 0 SlyX AAA_18 PF13238.6 EDK37203.2 - 0.59 10.7 4.5 0.69 10.5 1.7 2.0 2 0 0 2 2 2 0 AAA domain AA_permease PF00324.21 EDK37206.2 - 4.4e-52 177.2 46.1 5.7e-52 176.9 46.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK37206.2 - 6.3e-12 45.0 51.0 9.9e-12 44.4 51.0 1.2 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EDK37206.2 - 1.5e-08 34.1 2.2 1.9e-05 23.9 0.0 4.2 3 1 1 4 4 4 2 Solute carrier family 12 DUF5408 PF17402.2 EDK37206.2 - 3.9 7.4 7.4 1 9.3 3.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5408) DEAD PF00270.29 EDK37207.2 - 5.7e-50 169.5 0.0 1.4e-49 168.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37207.2 - 1.8e-28 99.1 0.0 6.5e-28 97.3 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDK37207.2 - 0.046 12.9 0.1 0.16 11.2 0.1 1.9 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase ECH_1 PF00378.20 EDK37208.2 - 2.8e-25 89.1 0.0 4.6e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDK37208.2 - 2.2e-23 83.3 0.0 2.7e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ATP13 PF12921.7 EDK37209.2 - 2.2e-28 98.4 0.2 6.2e-28 97.0 0.2 1.8 1 0 0 1 1 1 1 Mitochondrial ATPase expression Oscp1 PF10188.9 EDK37209.2 - 0.08 13.1 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Organic solute transport protein 1 Nop52 PF05997.12 EDK37210.2 - 7.9e-79 264.4 1.8 9.7e-79 264.1 1.8 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 ATP11 PF06644.11 EDK37210.2 - 0.052 13.3 0.3 0.052 13.3 0.3 1.9 2 0 0 2 2 2 0 ATP11 protein Slu7 PF11708.8 EDK37211.2 - 1.6e-14 54.4 14.2 5.7e-07 29.6 5.1 3.1 1 1 1 2 2 2 2 Pre-mRNA splicing Prp18-interacting factor BTK PF00779.19 EDK37211.2 - 0.0025 17.6 8.0 0.012 15.4 8.0 2.1 1 1 0 1 1 1 1 BTK motif HLH PF00010.26 EDK37212.2 - 6.3e-11 42.1 0.1 6.3e-11 42.1 0.1 2.2 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Cullin_binding PF03556.15 EDK37213.2 - 9.1e-33 113.3 5.4 1.5e-32 112.6 5.4 1.3 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 EDK37213.2 - 1.3e-14 53.8 0.0 3.1e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain Cullin PF00888.22 EDK37214.2 - 6.8e-16 58.0 0.8 1.6e-15 56.8 0.1 1.9 3 0 0 3 3 3 1 Cullin family HTH_27 PF13463.6 EDK37214.2 - 0.0089 16.5 0.0 0.39 11.2 0.0 2.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain PHB_acc PF05233.13 EDK37214.2 - 0.086 12.9 0.0 11 6.1 0.1 2.5 2 0 0 2 2 2 0 PHB accumulation regulatory domain MarR_2 PF12802.7 EDK37214.2 - 0.14 12.1 0.0 1.8 8.5 0.0 2.8 2 1 1 3 3 3 0 MarR family TFIID_20kDa PF03847.13 EDK37215.2 - 8.9e-30 103.0 0.2 2e-29 101.9 0.2 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 EDK37215.2 - 0.001 19.1 0.3 0.012 15.7 0.0 2.4 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EDK37215.2 - 0.012 15.9 0.1 0.028 14.7 0.0 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF4477 PF14780.6 EDK37215.2 - 0.3 10.7 1.4 0.53 9.9 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4477) Allexi_40kDa PF05549.11 EDK37215.2 - 3.1 7.2 6.3 16 4.9 3.9 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein XhlA PF10779.9 EDK37215.2 - 8 6.7 7.3 0.59 10.4 0.6 2.4 3 0 0 3 3 3 0 Haemolysin XhlA OPT PF03169.15 EDK37216.2 - 3.4e-131 438.9 41.6 4e-131 438.6 41.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sm_multidrug_ex PF06695.11 EDK37216.2 - 0.21 12.3 4.0 1.4 9.5 0.0 3.4 2 1 1 3 3 3 0 Putative small multi-drug export protein Helicase_C PF00271.31 EDK37217.2 - 4.5e-14 52.7 0.2 2.6e-13 50.3 0.0 2.5 3 0 0 3 3 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EDK37217.2 - 2.3e-13 50.4 0.5 1.2e-12 48.1 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDK37217.2 - 1.1e-09 38.5 0.0 4.8e-09 36.5 0.0 2.2 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDK37217.2 - 3.2e-08 33.5 0.0 1.1e-07 31.8 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RWD PF05773.22 EDK37217.2 - 5.6e-08 33.1 0.3 2.2e-07 31.2 0.3 2.1 1 0 0 1 1 1 1 RWD domain ResIII PF04851.15 EDK37217.2 - 8.2e-07 29.2 0.0 2.7e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EDK37217.2 - 4.5e-06 25.9 0.1 8.4e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 EDK37217.2 - 8.2e-05 22.1 0.0 0.0003 20.3 0.0 1.9 2 0 0 2 2 2 1 PhoH-like protein AAA_29 PF13555.6 EDK37217.2 - 0.0012 18.6 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.6 EDK37217.2 - 0.0029 17.9 0.1 0.008 16.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain ATPase PF06745.13 EDK37217.2 - 0.0082 15.5 1.1 0.011 15.1 0.0 1.8 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 EDK37217.2 - 0.011 15.3 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDK37217.2 - 0.024 15.1 0.5 0.024 15.1 0.5 4.6 3 1 0 4 4 4 0 AAA domain AAA_22 PF13401.6 EDK37217.2 - 0.033 14.5 0.1 0.14 12.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDK37217.2 - 0.034 13.8 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EDK37217.2 - 0.066 13.7 0.3 0.29 11.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter DND1_DSRM PF14709.7 EDK37217.2 - 0.094 13.0 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 LIAS_N PF16881.5 EDK37217.2 - 2.7 8.5 4.8 0.8 10.1 0.3 2.4 2 0 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family Zn_clus PF00172.18 EDK37218.2 - 3.8e-09 36.5 14.6 7.2e-09 35.6 14.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gp_dh_C PF02800.20 EDK37219.1 - 1.1e-69 233.0 0.0 1.8e-69 232.4 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDK37219.1 - 4.2e-40 136.2 0.1 8.9e-40 135.1 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDK37219.1 - 0.003 17.0 0.1 0.0065 15.9 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.20 EDK37219.1 - 0.027 14.6 0.5 0.082 13.0 0.5 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Rossmann-like PF10727.9 EDK37219.1 - 0.047 13.5 0.2 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Rossmann-like domain CENP-L PF13092.6 EDK37220.2 - 7.5e-05 23.0 0.4 0.012 15.8 0.4 3.2 1 1 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 PMT PF02366.18 EDK37221.2 - 6.5e-96 320.6 18.3 8e-96 320.3 18.3 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 EDK37221.2 - 2.6e-26 92.6 0.0 3.7e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EDK37221.2 - 6.6e-06 26.4 11.5 6.6e-06 26.4 11.5 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Fe-S_biosyn PF01521.20 EDK37222.2 - 4.4e-11 43.0 0.0 7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DGF-1_4 PF11024.8 EDK37222.2 - 0.15 12.9 0.1 0.22 12.4 0.1 1.3 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 HEAT PF02985.22 EDK37223.2 - 3.9e-39 129.3 17.1 0.00011 22.1 0.0 11.6 12 0 0 12 12 12 9 HEAT repeat HEAT_2 PF13646.6 EDK37223.2 - 3e-30 104.5 5.2 5.3e-08 33.1 0.0 7.5 3 3 6 9 9 9 8 HEAT repeats Cnd1 PF12717.7 EDK37223.2 - 1.7e-12 47.7 4.2 4.6e-05 23.5 0.1 5.9 2 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EDK37223.2 - 3.2e-12 45.8 0.0 5.8e-05 21.8 0.0 3.1 1 1 2 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 EDK37223.2 - 3.3e-12 46.6 2.5 0.57 10.7 0.1 7.4 5 1 1 6 6 6 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EDK37223.2 - 7.4e-12 45.7 0.2 0.017 15.7 0.0 6.8 3 2 5 8 8 8 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EDK37223.2 - 1.1e-06 28.8 3.8 0.23 11.6 0.1 4.8 4 2 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EDK37223.2 - 2.5e-05 24.2 0.6 14 5.9 0.0 6.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EDK37223.2 - 3e-05 23.3 0.1 0.42 9.7 0.0 3.2 3 1 0 3 3 3 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 EDK37223.2 - 0.00031 20.4 0.5 0.82 9.2 0.0 4.5 3 2 1 5 5 5 1 CLASP N terminal Uso1_p115_head PF04869.14 EDK37223.2 - 0.0014 17.9 0.1 0.88 8.6 0.0 3.2 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Trp_Tyr_perm PF03222.13 EDK37223.2 - 0.0048 16.0 0.1 0.0084 15.2 0.1 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family API5 PF05918.11 EDK37223.2 - 0.0085 15.0 2.4 0.19 10.5 0.0 3.3 4 0 0 4 4 4 1 Apoptosis inhibitory protein 5 (API5) Ecm29 PF13001.7 EDK37223.2 - 0.019 13.7 1.3 8.9 4.9 0.1 3.4 2 2 1 3 3 3 0 Proteasome stabiliser M11L PF11099.8 EDK37223.2 - 0.051 13.8 3.6 27 5.0 0.0 4.4 3 2 1 4 4 4 0 Apoptosis regulator M11L like Cohesin_HEAT PF12765.7 EDK37223.2 - 1 9.8 0.0 1 9.8 0.0 3.9 6 0 0 6 6 4 0 HEAT repeat associated with sister chromatid cohesion His_Phos_1 PF00300.22 EDK37224.2 - 1.9e-11 44.0 0.1 8.6e-11 41.9 0.1 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SPX PF03105.19 EDK37226.2 - 1e-05 25.7 11.4 5.7e-05 23.2 0.0 3.2 2 1 0 3 3 3 2 SPX domain DUF1902 PF08972.11 EDK37226.2 - 0.071 13.1 0.1 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) NIR_SIR PF01077.22 EDK37227.2 - 2e-51 173.6 0.0 4.3e-48 162.8 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EDK37227.2 - 1.5e-29 101.7 0.1 8.4e-15 54.4 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EDK37227.2 - 2.4e-26 92.7 0.0 6.3e-26 91.3 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EDK37227.2 - 0.0035 17.1 0.0 0.031 14.0 0.0 2.1 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Nbl1_Borealin_N PF10444.9 EDK37228.2 - 1.7e-05 24.3 1.3 2.6e-05 23.8 1.3 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 EDK37229.2 - 1.1e-20 74.2 0.1 9.6e-20 71.2 0.0 2.2 2 1 1 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 EDK37229.2 - 9.3e-09 35.8 0.6 1.4e-08 35.2 0.6 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 EDK37229.2 - 4.5e-06 26.6 0.0 6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EDK37229.2 - 0.0062 16.4 0.3 0.017 15.0 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif PDH PF02153.17 EDK37229.2 - 0.028 13.4 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase OSK PF17182.4 EDK37229.2 - 0.036 13.3 0.2 0.058 12.6 0.2 1.3 1 0 0 1 1 1 0 OSK domain DUF4362 PF14275.6 EDK37229.2 - 0.089 13.1 0.9 18 5.7 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4362) GAF PF01590.26 EDK37230.2 - 0.0018 18.9 0.0 0.0045 17.6 0.0 1.7 1 0 0 1 1 1 1 GAF domain Swi3 PF07962.12 EDK37231.2 - 3e-20 72.0 0.3 4.5e-20 71.4 0.3 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 HECT_2 PF09814.9 EDK37233.2 - 3.1e-58 197.4 0.1 3.9e-58 197.1 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DHHA2 PF02833.14 EDK37234.2 - 5.4e-30 104.5 0.1 1.3e-29 103.2 0.1 1.7 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 EDK37234.2 - 2e-09 37.6 0.4 8.9e-09 35.5 0.1 1.9 1 1 1 2 2 2 1 DHH family PMT PF02366.18 EDK37235.2 - 4.4e-80 268.8 20.8 9.7e-80 267.7 20.8 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDK37235.2 - 7.7e-63 211.7 6.0 7.7e-63 211.7 6.0 3.3 3 0 0 3 3 3 2 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDK37235.2 - 1.3e-16 61.0 1.1 2.1e-16 60.3 1.1 1.2 1 0 0 1 1 1 1 MIR domain SlyX PF04102.12 EDK37236.2 - 0.077 13.6 4.8 5.2 7.8 0.0 4.1 2 1 0 3 3 3 0 SlyX DUF743 PF05332.11 EDK37236.2 - 0.099 12.7 3.1 3.6 7.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF743) Apolipoprotein PF01442.18 EDK37236.2 - 0.5 10.2 9.7 0.1 12.5 3.0 2.3 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Rho_Binding PF08912.11 EDK37236.2 - 1.8 9.4 8.8 7.3 7.5 1.0 3.3 2 1 0 2 2 2 0 Rho Binding PKcGMP_CC PF16808.5 EDK37236.2 - 3.8 7.5 11.0 0.26 11.2 0.3 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase NUDIX PF00293.28 EDK37237.2 - 1e-08 35.3 0.0 2.1e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 EDK37237.2 - 1.3e-08 34.8 0.0 1.9e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) DUF5064 PF16703.5 EDK37238.2 - 0.0052 17.3 0.1 1.1 9.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5064) PQ-loop PF04193.14 EDK37240.2 - 3.7e-24 84.3 4.2 8.4e-20 70.3 0.2 2.8 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EDK37240.2 - 0.38 11.6 5.9 2.3 9.0 0.0 2.9 2 1 1 3 3 3 0 ER lumen protein retaining receptor Epiglycanin_C PF14654.6 EDK37240.2 - 5.2 7.2 6.7 1.2 9.3 0.6 2.4 1 1 1 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region Rad4 PF03835.15 EDK37241.2 - 6.9e-33 113.4 3.3 1.8e-32 112.0 3.3 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EDK37241.2 - 1.3e-20 73.5 0.0 2.8e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EDK37241.2 - 1.5e-16 60.0 0.0 3.2e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EDK37241.2 - 1.3e-09 38.9 0.4 1.6e-08 35.4 0.4 3.0 1 1 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EDK37241.2 - 0.0048 17.3 0.0 0.012 16.0 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily GRP PF07172.11 EDK37241.2 - 1.6 9.5 8.3 4.3 8.1 8.3 1.7 1 0 0 1 1 1 0 Glycine rich protein family Lyase_1 PF00206.20 EDK37243.2 - 1.4e-117 392.5 0.0 1.9e-117 392.2 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EDK37243.2 - 2.1e-24 85.7 0.0 4.7e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus SPT2 PF08243.11 EDK37244.2 - 4.5e-28 98.0 25.0 4.5e-28 98.0 25.0 2.4 2 0 0 2 2 2 1 SPT2 chromatin protein Rit1_C PF17184.4 EDK37245.2 - 1.1e-83 280.8 0.0 1.8e-83 280.2 0.0 1.3 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EDK37245.2 - 6.4e-26 90.8 0.6 1.2e-25 89.9 0.1 1.8 2 0 0 2 2 2 1 Rit1 DUSP-like domain Myc-LZ PF02344.15 EDK37245.2 - 1.8 8.8 5.6 0.73 10.0 1.8 2.2 2 0 0 2 2 2 0 Myc leucine zipper domain FSH1 PF03959.13 EDK37246.2 - 9.4e-52 175.8 0.0 1.1e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EDK37246.2 - 3.1e-05 23.8 0.2 0.019 14.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EDK37246.2 - 0.004 17.0 0.1 0.014 15.3 0.1 1.9 1 1 0 1 1 1 1 Serine hydrolase BAAT_C PF08840.11 EDK37246.2 - 0.018 15.0 0.0 0.031 14.2 0.0 1.4 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EDK37246.2 - 0.024 14.5 0.1 1.2 8.9 0.1 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pox_MCEL PF03291.16 EDK37247.2 - 3.4e-99 332.1 0.0 4.7e-99 331.6 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EDK37247.2 - 3.4e-09 37.3 0.0 1.4e-05 25.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDK37247.2 - 7.6e-06 26.6 0.0 2.8e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK37247.2 - 0.00018 21.3 0.1 0.0007 19.4 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Vel1p PF10339.9 EDK37247.2 - 0.00028 20.3 0.0 0.00058 19.3 0.0 1.4 1 0 0 1 1 1 1 Yeast-specific zinc responsive Methyltransf_11 PF08241.12 EDK37247.2 - 0.00031 21.3 0.0 0.45 11.2 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EDK37247.2 - 0.0006 19.7 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDK37247.2 - 0.15 11.2 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family FOXP-CC PF16159.5 EDK37248.2 - 0.03 15.0 0.1 0.065 13.9 0.1 1.5 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EDK37248.2 - 0.037 14.3 0.5 0.077 13.3 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf_Hakai PF18408.1 EDK37248.2 - 0.065 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain zf-C2H2 PF00096.26 EDK37248.2 - 0.074 13.5 1.4 0.16 12.5 1.4 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EDK37248.2 - 0.11 12.9 0.2 0.17 12.2 0.2 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EDK37248.2 - 0.2 12.1 2.0 0.5 10.8 2.0 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type TMF_TATA_bd PF12325.8 EDK37250.2 - 9.8e-30 103.1 16.8 9.8e-30 103.1 16.8 6.0 2 1 2 5 5 5 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EDK37250.2 - 3.8e-16 58.8 12.4 3.8e-16 58.8 12.4 8.7 5 3 1 7 7 7 1 TATA element modulatory factor 1 DNA binding UPF0242 PF06785.11 EDK37250.2 - 0.0045 17.1 8.9 0.0045 17.1 8.9 4.7 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0242) N-terminus HALZ PF02183.18 EDK37250.2 - 0.0088 16.2 0.4 0.0088 16.2 0.4 7.0 7 1 0 7 7 7 3 Homeobox associated leucine zipper Utp12 PF04003.12 EDK37251.2 - 1.3e-16 60.8 0.0 2.1e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Pribosyltran PF00156.27 EDK37253.1 - 6.7e-08 32.2 0.0 8.9e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain IBN_N PF03810.19 EDK37254.2 - 4.9e-15 55.2 0.1 4e-14 52.3 0.0 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 EDK37254.2 - 2.9e-07 29.6 0.0 2.6e-06 26.5 0.0 2.4 1 1 0 1 1 1 1 Cse1 DUF3533 PF12051.8 EDK37255.1 - 3.5e-19 69.0 0.0 4.9e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF3884 PF13024.6 EDK37255.1 - 0.044 13.4 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) DUF3533 PF12051.8 EDK37256.2 - 1.6e-82 277.5 21.5 1.9e-82 277.2 21.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) SurE PF01975.17 EDK37257.2 - 1.7e-06 28.0 0.0 2.4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE YihI PF04220.12 EDK37257.2 - 2 8.1 6.6 0.59 9.9 0.4 2.7 1 1 2 3 3 3 0 Der GTPase activator (YihI) AA_permease_2 PF13520.6 EDK37258.2 - 1.2e-58 199.0 35.5 1.4e-58 198.7 35.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK37258.2 - 0.00038 19.2 29.0 0.00038 19.2 29.0 1.7 2 0 0 2 2 2 1 Amino acid permease DUF5401 PF17380.2 EDK37259.2 - 0.1 10.6 10.4 0.14 10.2 10.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Pex26 PF07163.12 EDK37259.2 - 0.27 10.5 6.7 0.54 9.5 6.6 1.6 1 1 0 1 1 1 0 Pex26 protein Presenilin PF01080.17 EDK37259.2 - 0.61 8.8 3.5 0.9 8.2 3.5 1.3 1 0 0 1 1 1 0 Presenilin G6B PF15096.6 EDK37259.2 - 7.1 6.4 5.8 25 4.6 0.1 2.2 2 0 0 2 2 2 0 G6B family Rad1 PF02144.16 EDK37260.2 - 1.1e-76 257.5 0.1 1.4e-76 257.1 0.1 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 vATP-synt_AC39 PF01992.16 EDK37261.2 - 6.6e-105 351.3 0.2 7.4e-105 351.1 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Dor1 PF04124.12 EDK37262.2 - 4.8e-18 65.0 15.1 3.1e-15 55.7 9.0 2.3 2 1 0 2 2 2 2 Dor1-like family RNA_pol_Rpb1_6 PF04992.14 EDK37262.2 - 0.0017 18.2 2.1 0.0036 17.2 2.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 End3 PF12761.7 EDK37262.2 - 0.014 15.6 0.6 0.034 14.3 0.6 1.6 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SNF2_N PF00176.23 EDK37263.2 - 1.4e-57 195.0 0.0 2.9e-57 194.0 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK37263.2 - 1e-21 77.4 0.1 2e-20 73.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37263.2 - 4e-08 33.4 0.1 4e-07 30.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 EDK37263.2 - 2.3e-06 27.3 3.6 4.5e-06 26.4 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK37263.2 - 0.00017 21.5 6.2 0.0004 20.4 6.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDK37263.2 - 0.00098 19.4 6.0 0.00098 19.4 6.0 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK37263.2 - 0.001 18.9 4.0 0.0025 17.6 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK37263.2 - 0.0012 18.7 6.1 0.0027 17.6 6.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDK37263.2 - 0.0017 18.2 4.6 0.0078 16.1 4.7 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 EDK37263.2 - 0.0057 16.4 0.1 0.065 13.0 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase ERM PF00769.19 EDK37263.2 - 0.076 12.8 13.0 0.18 11.6 13.0 1.6 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Prok-RING_4 PF14447.6 EDK37263.2 - 0.22 11.4 8.1 5 7.1 8.8 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 EDK37263.2 - 0.24 11.3 4.0 0.55 10.2 4.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FPP PF05911.11 EDK37263.2 - 0.36 8.9 8.7 0.012 13.8 2.7 1.5 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil FYVE PF01363.21 EDK37263.2 - 0.96 9.6 3.9 2.4 8.4 3.9 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf-RING_4 PF14570.6 EDK37263.2 - 1.3 8.9 4.5 3.2 7.6 4.5 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EDK37263.2 - 1.4 9.2 6.6 3.6 7.8 6.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF16 PF01519.16 EDK37263.2 - 7.5 7.1 6.7 39 4.8 0.1 3.0 3 0 0 3 3 2 0 Protein of unknown function DUF16 TPR_1 PF00515.28 EDK37264.1 - 1.6e-06 27.7 2.8 5.3e-05 22.8 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK37264.1 - 6.1e-06 26.0 4.2 0.00049 20.0 0.2 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDK37264.1 - 1.4e-05 25.2 0.1 4.7e-05 23.5 0.1 1.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDK37264.1 - 3.4e-05 23.4 0.1 0.00036 20.1 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 EDK37264.1 - 0.0075 16.4 0.2 0.048 13.9 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37264.1 - 0.073 13.9 0.0 0.67 10.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat rve_3 PF13683.6 EDK37264.1 - 0.13 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain TPR_12 PF13424.6 EDK37264.1 - 0.14 12.4 0.6 0.93 9.8 0.4 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK37264.1 - 0.56 10.9 3.3 13 6.6 1.6 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EDK37266.1 - 1.1e-61 209.1 0.0 1.2e-61 208.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDK37266.1 - 0.011 14.3 0.0 0.018 13.6 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme HHH PF00633.23 EDK37266.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_S17 PF00366.20 EDK37267.1 - 1.6e-21 76.1 4.1 3.4e-21 75.1 4.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 Ion_trans_2 PF07885.16 EDK37268.2 - 6e-28 96.6 35.4 1.2e-17 63.6 6.6 3.5 3 0 0 3 3 3 2 Ion channel hDGE_amylase PF14701.6 EDK37268.2 - 0.0067 15.6 0.1 0.01 14.9 0.1 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Nucleoside_tran PF01733.18 EDK37269.2 - 4.2e-51 174.2 4.7 8.1e-51 173.2 4.7 1.5 1 0 0 1 1 1 1 Nucleoside transporter AIM3 PF17096.5 EDK37270.2 - 0.0033 18.3 3.3 0.0033 18.3 3.3 6.3 5 3 0 5 5 5 2 Altered inheritance of mitochondria protein 3 Diphthamide_syn PF01866.17 EDK37271.2 - 7.8e-70 235.7 0.0 1.1e-69 235.2 0.0 1.3 1 0 0 1 1 1 1 Putative diphthamide synthesis protein SPC25 PF06703.11 EDK37272.1 - 1.1e-28 100.0 4.3 1.2e-28 99.9 4.3 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) zf-RING_UBOX PF13445.6 EDK37273.2 - 5.3e-07 29.5 3.6 1.3e-06 28.3 3.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDK37273.2 - 1.3e-06 28.2 3.4 2.5e-06 27.3 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK37273.2 - 1.7e-06 27.9 5.2 9.2e-06 25.5 5.6 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDK37273.2 - 5.5e-06 26.1 5.4 7.9e-06 25.6 1.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK37273.2 - 8.2e-06 26.1 5.4 2.5e-05 24.5 5.4 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDK37273.2 - 0.00045 20.0 5.7 0.0015 18.4 5.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK37273.2 - 0.0013 18.9 4.0 0.0065 16.6 4.3 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDK37273.2 - 0.017 14.9 11.2 4.5 7.2 11.4 3.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EDK37273.2 - 0.42 10.9 2.0 1.3 9.4 2.0 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 EDK37273.2 - 1.3 9.0 3.6 0.54 10.2 0.3 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TFR_dimer PF04253.15 EDK37274.2 - 1.7e-24 86.2 1.9 3.6e-24 85.2 1.9 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDK37274.2 - 1.6e-07 31.2 0.0 2.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDK37274.2 - 1.1e-06 28.5 0.0 1.2e-05 25.2 0.0 2.4 1 1 0 1 1 1 1 PA domain ChaC PF04752.12 EDK37275.2 - 3.1e-52 177.2 0.0 5.5e-52 176.4 0.0 1.4 1 1 0 1 1 1 1 ChaC-like protein Nha1_C PF08619.10 EDK37276.2 - 2.4e-67 228.2 46.3 1.4e-66 225.6 46.3 1.9 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EDK37276.2 - 1.7e-64 218.0 20.4 2e-64 217.7 20.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FlgD_ig PF13860.6 EDK37276.2 - 0.06 13.2 0.4 1.7 8.6 0.1 2.5 2 0 0 2 2 2 0 FlgD Ig-like domain Colicin_E5 PF12106.8 EDK37276.2 - 0.16 12.3 9.6 0.51 10.7 0.3 3.5 3 1 0 3 3 3 0 Colicin E5 ribonuclease domain PBP1_TM PF14812.6 EDK37276.2 - 5.8 7.4 10.4 1.4 9.4 4.6 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aminotran_3 PF00202.21 EDK37277.1 - 4.6e-119 397.7 0.0 5.4e-119 397.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDK37277.1 - 0.0018 17.5 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDK37277.1 - 0.017 14.4 0.0 0.049 12.9 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase RNR_inhib PF08591.10 EDK37278.1 - 2.6e-08 35.1 0.6 9.5e-08 33.3 0.1 1.9 1 1 1 2 2 2 1 Ribonucleotide reductase inhibitor SUR7 PF06687.12 EDK37279.2 - 2.7e-25 89.3 5.3 3.5e-25 88.9 5.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family DPM3 PF08285.11 EDK37279.2 - 0.12 12.6 0.3 0.12 12.6 0.3 2.4 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Fig1 PF12351.8 EDK37279.2 - 0.24 11.3 7.8 0.072 13.0 4.3 1.8 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 TSP_C PF05735.12 EDK37280.2 - 0.035 14.0 1.5 0.063 13.2 1.5 1.3 1 0 0 1 1 1 0 Thrombospondin C-terminal region DUF373 PF04123.13 EDK37280.2 - 2.2 7.7 5.0 2.9 7.2 4.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DUF4271 PF14093.6 EDK37280.2 - 3.1 7.6 9.4 2.1 8.2 1.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4271) Cys_Met_Meta_PP PF01053.20 EDK37281.2 - 3.5e-143 476.8 0.0 3.9e-143 476.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK37281.2 - 2.5e-10 40.1 0.0 4e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDK37281.2 - 1.6e-08 33.9 0.3 2.5e-08 33.3 0.3 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDK37281.2 - 2.2e-07 30.5 0.0 4.5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 EDK37281.2 - 0.00041 19.0 0.1 0.00064 18.4 0.1 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 EDK37281.2 - 0.0022 17.3 0.0 0.0036 16.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 EDK37281.2 - 0.059 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Corona_NS2 PF04753.12 EDK37282.2 - 0.027 15.0 1.5 0.042 14.4 1.5 1.4 1 0 0 1 1 1 0 Coronavirus non-structural protein NS2 DEAD PF00270.29 EDK37283.2 - 2.2e-36 125.2 0.0 4.7e-36 124.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37283.2 - 3.4e-26 91.8 0.2 6.4e-25 87.7 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37283.2 - 5.2e-09 36.3 0.0 1.1e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDK37283.2 - 0.011 15.0 0.4 0.035 13.4 0.1 1.8 2 1 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 EDK37283.2 - 0.15 12.7 1.2 0.26 11.9 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) P5CR_dimer PF14748.6 EDK37284.2 - 6.6e-35 119.5 1.6 1.2e-34 118.6 1.6 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EDK37284.2 - 1.6e-16 60.6 0.0 4e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EDK37284.2 - 0.00038 20.7 0.0 0.00077 19.7 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 EDK37284.2 - 0.0068 16.1 0.1 0.012 15.3 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA B277 PF17623.2 EDK37284.2 - 0.019 14.1 0.2 0.035 13.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function Shikimate_DH PF01488.20 EDK37284.2 - 0.024 14.7 0.2 0.061 13.4 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase JmjC PF02373.22 EDK37285.2 - 1.5e-39 134.9 1.3 2.3e-39 134.4 0.1 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase PHD PF00628.29 EDK37285.2 - 2.7e-12 46.4 6.4 2.7e-12 46.4 6.4 2.1 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.17 EDK37285.2 - 1.6e-10 40.8 0.1 5.3e-10 39.1 0.1 2.0 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.6 EDK37285.2 - 0.0011 18.4 0.7 0.0011 18.4 0.7 2.0 2 0 0 2 2 2 1 PHD-finger ARID PF01388.21 EDK37285.2 - 0.0016 19.1 0.3 0.0068 17.1 0.0 2.2 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain zf-HC5HC2H PF13771.6 EDK37285.2 - 0.016 15.4 1.4 0.094 13.0 1.4 2.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Prok-RING_1 PF14446.6 EDK37285.2 - 0.04 13.9 2.0 0.12 12.3 2.0 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-HC5HC2H_2 PF13832.6 EDK37285.2 - 0.057 13.6 0.9 0.24 11.6 0.9 2.1 1 0 0 1 1 1 0 PHD-zinc-finger like domain C1_2 PF03107.16 EDK37285.2 - 0.17 12.2 9.0 0.055 13.8 4.3 2.5 2 0 0 2 2 2 0 C1 domain zf-RING_2 PF13639.6 EDK37285.2 - 0.51 10.7 12.9 0.17 12.2 8.6 2.6 2 1 0 2 2 2 0 Ring finger domain ATP-synt_ab PF00006.25 EDK37286.2 - 3.3e-62 209.9 0.0 4.8e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDK37286.2 - 7.8e-22 77.6 0.6 4.4e-21 75.2 0.6 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 EDK37286.2 - 0.0017 17.7 0.2 0.003 16.9 0.2 1.4 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 EDK37286.2 - 0.022 13.9 0.4 0.073 12.2 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain T3SS_ATPase_C PF18269.1 EDK37286.2 - 0.033 14.1 0.3 0.22 11.4 0.3 2.3 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RsgA_GTPase PF03193.16 EDK37286.2 - 0.036 14.0 0.1 0.08 12.8 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 EDK37286.2 - 0.046 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 EDK37286.2 - 0.097 13.0 0.7 0.46 10.8 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDK37286.2 - 0.1 13.0 0.2 0.33 11.3 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EDK37286.2 - 0.11 13.0 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 EDK37286.2 - 0.12 12.8 0.1 1.7 9.1 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Pox_A32 PF04665.12 EDK37286.2 - 0.25 10.8 0.1 0.48 9.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Peptidase_M48 PF01435.18 EDK37287.1 - 7.4e-45 153.1 0.2 1.1e-44 152.6 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.5 EDK37287.1 - 1.2e-37 129.6 9.0 1.2e-37 129.6 9.0 2.2 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices DUF4538 PF15061.6 EDK37287.1 - 0.19 11.4 0.7 0.53 10.1 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) DUF2201_N PF13203.6 EDK37287.1 - 0.3 10.6 0.6 0.51 9.9 0.6 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain Zn_peptidase_2 PF04298.12 EDK37287.1 - 0.35 10.2 4.9 0.09 12.2 1.4 1.6 1 1 0 2 2 2 0 Putative neutral zinc metallopeptidase LUC7 PF03194.15 EDK37288.1 - 8.8e-61 205.7 6.2 1.1e-60 205.5 6.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Imm49 PF15575.6 EDK37288.1 - 0.00099 18.9 0.3 0.0021 17.9 0.1 1.6 2 0 0 2 2 2 1 Immunity protein 49 HlyD_2 PF12700.7 EDK37288.1 - 0.0031 16.3 2.4 0.004 15.9 2.4 1.1 1 0 0 1 1 1 1 HlyD family secretion protein DUF4200 PF13863.6 EDK37288.1 - 0.11 12.9 5.6 4 7.9 7.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) HAD_2 PF13419.6 EDK37288.1 - 0.2 11.7 1.2 0.47 10.5 1.5 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase ArnB_C PF18677.1 EDK37288.1 - 2.1 8.5 5.4 3.4 7.8 2.3 2.7 2 1 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain AAA_18 PF13238.6 EDK37288.1 - 3.2 8.3 5.5 9.4 6.8 1.1 2.3 1 1 1 2 2 2 0 AAA domain F-box-like PF12937.7 EDK37289.2 - 1e-09 38.1 0.5 2.4e-09 36.9 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK37289.2 - 2.8e-05 23.9 0.4 9.3e-05 22.2 0.4 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDK37289.2 - 0.00023 21.0 1.3 0.0034 17.2 0.0 2.8 2 1 1 3 3 3 1 F-box Glyco_hydro_72 PF03198.14 EDK37290.2 - 1.2e-23 83.8 0.0 1.9e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase GP70 PF17429.2 EDK37290.2 - 0.1 12.4 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Gene product 70 Peptidase_M28 PF04389.17 EDK37291.2 - 5.3e-39 134.0 0.0 7.5e-38 130.2 0.0 2.2 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDK37291.2 - 0.0066 16.2 0.0 0.012 15.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EDK37291.2 - 0.084 11.9 0.0 0.36 9.8 0.0 1.8 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase URO-D PF01208.17 EDK37292.2 - 3.1e-90 302.8 0.0 3.4e-90 302.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) bVLRF1 PF18826.1 EDK37293.2 - 5.3e-59 198.4 0.2 1.1e-58 197.3 0.2 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EDK37293.2 - 9.4e-05 22.6 0.0 0.00025 21.3 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EDK37293.2 - 0.0047 17.3 1.7 0.007 16.8 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EDK37293.2 - 0.0076 16.8 0.0 0.023 15.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK37293.2 - 0.018 15.7 0.0 0.046 14.3 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) E2_bind PF08825.10 EDK37293.2 - 0.094 12.9 4.4 0.84 9.8 0.1 2.8 3 0 0 3 3 3 0 E2 binding domain SNF2_N PF00176.23 EDK37294.2 - 1.6e-51 175.1 0.0 2.9e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK37294.2 - 3.9e-15 56.1 0.1 2.4e-14 53.6 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37294.2 - 2.4e-14 53.7 0.1 7.6e-14 52.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK37294.2 - 0.00099 18.4 2.1 0.0012 18.1 0.6 1.8 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DUF3783 PF12646.7 EDK37294.2 - 0.074 13.0 0.0 0.28 11.2 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) SRP-alpha_N PF04086.13 EDK37294.2 - 1.1 9.1 6.4 2.2 8.1 6.4 1.6 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF2428 PF10350.9 EDK37295.2 - 2.4e-48 164.8 1.2 2.4e-48 164.8 1.2 3.0 2 1 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EDK37295.2 - 0.034 14.4 0.5 10 6.7 0.0 5.1 5 0 0 5 5 5 0 HEAT repeat Lactamase_B_2 PF12706.7 EDK37296.2 - 7.5e-08 32.1 0.0 1.6e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DAGK_acc PF00609.19 EDK37296.2 - 0.0025 18.2 0.0 0.0055 17.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DRMBL PF07522.14 EDK37296.2 - 0.0031 17.7 0.1 0.01 16.0 0.1 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 EDK37296.2 - 0.0041 17.0 0.0 0.0096 15.8 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EDK37296.2 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDK37296.2 - 0.11 12.4 0.1 0.37 10.7 0.1 1.8 2 0 0 2 2 2 0 Beta-lactamase superfamily domain TFIIS_C PF01096.18 EDK37297.2 - 1.7e-22 78.9 2.2 1.7e-22 78.9 2.2 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EDK37297.2 - 3.3e-07 30.0 7.5 3.9e-07 29.8 4.3 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit IBR PF01485.21 EDK37297.2 - 0.021 15.1 9.4 0.093 13.0 0.7 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Zn_Tnp_IS1595 PF12760.7 EDK37297.2 - 0.022 14.7 8.4 0.047 13.7 0.4 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Baculo_LEF5_C PF11792.8 EDK37297.2 - 0.036 13.7 0.2 0.036 13.7 0.2 2.3 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain zf-piccolo PF05715.13 EDK37297.2 - 0.044 13.9 4.4 0.27 11.4 1.8 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger PhnA_Zn_Ribbon PF08274.12 EDK37297.2 - 6.5 6.8 10.8 0.64 10.0 0.1 3.0 2 1 0 2 2 2 0 PhnA Zinc-Ribbon ORC2 PF04084.14 EDK37298.2 - 6.6e-101 337.5 1.3 1e-100 336.9 1.3 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Pkinase PF00069.25 EDK37299.2 - 3.2e-39 134.9 0.0 6.8e-39 133.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37299.2 - 8.4e-25 87.5 0.0 1.4e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDK37299.2 - 2.7e-07 30.2 0.0 5.3e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK37299.2 - 0.083 12.8 0.0 11 5.9 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDK37299.2 - 0.12 11.1 1.4 0.24 10.1 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase TPR_1 PF00515.28 EDK37300.2 - 2.4e-05 23.9 0.3 0.86 9.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDK37300.2 - 0.00032 21.2 0.4 0.93 10.0 0.2 4.6 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDK37300.2 - 0.00032 20.7 5.0 0.14 12.5 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDK37300.2 - 0.00055 20.1 2.0 0.098 13.1 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK37300.2 - 0.00055 19.8 4.0 20 5.6 0.1 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37300.2 - 0.00098 19.8 4.9 0.91 10.5 0.1 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat RPN7 PF10602.9 EDK37300.2 - 0.0076 16.0 0.8 31 4.2 0.0 4.0 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_12 PF13424.6 EDK37300.2 - 0.023 15.0 5.6 9.1 6.6 0.0 4.7 3 2 1 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK37300.2 - 0.35 11.1 8.0 0.3 11.3 0.7 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EDK37300.2 - 0.53 10.0 2.8 65 3.3 0.0 3.9 4 0 0 4 4 4 0 TPR repeat Mg_trans_NIPA PF05653.14 EDK37302.2 - 9.9e-109 363.0 17.4 1.2e-108 362.7 17.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDK37302.2 - 3.8e-05 23.9 5.7 3.8e-05 23.9 5.7 3.2 3 0 0 3 3 3 1 EamA-like transporter family Tetraspanin PF00335.20 EDK37302.2 - 7 6.3 14.1 5.7 6.6 0.9 3.4 3 0 0 3 3 3 0 Tetraspanin family DUF1282 PF06930.12 EDK37302.2 - 9.6 5.9 22.4 0.96 9.2 10.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1282) eIF-1a PF01176.19 EDK37303.1 - 3.9e-20 71.4 0.1 5.4e-20 71.0 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CTK3 PF12243.8 EDK37304.2 - 4.8e-47 159.0 1.2 8e-47 158.3 0.7 1.6 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EDK37304.2 - 5.7e-22 77.7 0.9 1.4e-21 76.4 0.9 1.7 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus Glyco_transf_20 PF00982.21 EDK37305.2 - 3e-148 494.4 0.0 4.1e-148 494.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDK37305.2 - 2.3e-19 69.4 0.0 6.8e-19 67.9 0.0 1.8 1 1 0 1 1 1 1 Trehalose-phosphatase Peptidase_M19 PF01244.21 EDK37305.2 - 0.1 11.8 0.1 2.9 7.0 0.0 2.9 2 2 2 4 4 4 0 Membrane dipeptidase (Peptidase family M19) TatD_DNase PF01026.21 EDK37306.2 - 1e-35 123.3 0.0 1.3e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase TIM PF00121.18 EDK37307.1 - 5.9e-88 294.3 0.0 6.7e-88 294.2 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase His_Phos_1 PF00300.22 EDK37308.2 - 4.8e-28 98.2 0.0 3.7e-27 95.3 0.0 2.3 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) PAN_4 PF14295.6 EDK37308.2 - 0.0099 15.8 0.5 0.026 14.4 0.5 1.7 1 0 0 1 1 1 1 PAN domain Colicin_immun PF09204.10 EDK37309.2 - 0.052 14.1 1.1 0.14 12.7 0.9 1.9 1 1 0 1 1 1 0 Bacterial self-protective colicin-like immunity Pdase_M17_N2 PF18295.1 EDK37309.2 - 0.063 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 M17 aminopeptidase N-terminal domain 2 tRNA-synt_2 PF00152.20 EDK37310.2 - 5.9e-77 258.8 0.1 8.9e-77 258.2 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDK37310.2 - 3.4e-11 43.0 0.0 6.7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDK37310.2 - 2.4e-07 30.5 0.1 0.003 17.1 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FtsJ PF01728.19 EDK37311.2 - 5.3e-68 228.6 0.0 6.6e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribosomal_S10 PF00338.22 EDK37312.2 - 4.6e-20 71.7 0.0 9.8e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FAD-oxidase_C PF02913.19 EDK37314.2 - 5.7e-54 183.4 0.0 8.3e-54 182.8 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDK37314.2 - 1.1e-40 138.6 0.4 2e-40 137.7 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain Lact-deh-memb PF09330.11 EDK37314.2 - 0.00038 19.9 0.0 0.00073 19.0 0.0 1.4 1 0 0 1 1 1 1 D-lactate dehydrogenase, membrane binding GTP_EFTU PF00009.27 EDK37316.2 - 3.6e-05 23.4 0.0 0.0047 16.5 0.0 2.6 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK37316.2 - 0.00038 20.5 0.9 0.0048 17.0 0.9 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EDK37316.2 - 0.0018 18.4 0.2 0.0052 16.9 0.2 1.8 1 1 0 1 1 1 1 Dynamin family Septin PF00735.18 EDK37316.2 - 0.02 14.2 0.1 2 7.7 0.1 2.3 2 0 0 2 2 2 0 Septin AAA_29 PF13555.6 EDK37316.2 - 0.085 12.6 0.8 0.2 11.4 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain TPR_1 PF00515.28 EDK37317.2 - 1.6e-13 49.8 8.8 0.00031 20.4 0.1 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDK37317.2 - 2.2e-12 46.1 22.0 0.00037 20.4 0.2 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDK37317.2 - 6.8e-09 36.2 25.7 0.091 13.4 2.0 6.4 5 1 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37317.2 - 9.6e-09 35.3 29.4 0.19 12.7 1.5 7.9 6 3 3 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK37317.2 - 1.5e-07 31.0 4.2 1.2 9.5 0.2 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDK37317.2 - 2e-07 31.4 0.6 3.7e-06 27.3 0.1 6.0 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDK37317.2 - 9.2e-07 28.8 14.2 1.4 9.4 0.1 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDK37317.2 - 1.4e-06 27.9 12.9 0.01 15.5 0.3 5.6 5 1 1 6 6 6 2 TPR repeat TPR_12 PF13424.6 EDK37317.2 - 4.6e-06 26.8 29.1 0.018 15.3 0.2 6.6 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDK37317.2 - 1.6e-05 24.9 17.3 0.0038 17.3 0.2 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat EPL1 PF10513.9 EDK37317.2 - 0.00082 19.8 9.5 0.032 14.6 6.4 2.4 2 0 0 2 2 2 1 Enhancer of polycomb-like TPR_7 PF13176.6 EDK37317.2 - 0.0014 18.5 10.9 7.2 6.9 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat DDHD PF02862.17 EDK37317.2 - 0.0059 16.8 4.1 0.41 10.8 1.9 2.3 2 0 0 2 2 2 1 DDHD domain MTP18 PF10558.9 EDK37317.2 - 0.024 14.6 1.1 1.5 8.8 0.3 2.4 2 0 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) DUF5523 PF17661.1 EDK37317.2 - 0.039 13.6 15.2 0.23 11.1 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF3801 PF12687.7 EDK37317.2 - 0.086 12.9 8.4 0.23 11.5 5.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) AAA_lid_9 PF17871.1 EDK37317.2 - 0.32 10.9 0.1 0.32 10.9 0.1 2.8 3 0 0 3 3 2 0 AAA lid domain CPSF100_C PF13299.6 EDK37317.2 - 0.38 10.9 9.5 1.6 8.9 4.5 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TPR_6 PF13174.6 EDK37317.2 - 1.8 9.3 16.9 1.6 9.6 0.6 5.7 6 0 0 6 6 4 0 Tetratricopeptide repeat BORG_CEP PF14957.6 EDK37317.2 - 3 9.0 7.5 13 7.0 4.3 2.4 2 0 0 2 2 2 0 Cdc42 effector Presenilin PF01080.17 EDK37317.2 - 3.5 6.3 16.3 8.3 5.0 12.2 2.1 2 0 0 2 2 2 0 Presenilin TPR_15 PF13429.6 EDK37317.2 - 3.7 6.7 23.0 0.04 13.1 1.0 4.4 3 2 0 5 5 4 0 Tetratricopeptide repeat PEHE PF15275.6 EDK37317.2 - 4.3 8.0 15.7 39 4.9 12.9 2.5 2 0 0 2 2 2 0 PEHE domain Peroxin-13_N PF04088.13 EDK37317.2 - 4.3 7.6 5.4 46 4.3 3.1 2.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Tim54 PF11711.8 EDK37317.2 - 4.7 5.9 12.0 2.4 6.8 6.0 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Gti1_Pac2 PF09729.9 EDK37317.2 - 5.2 7.1 11.4 43 4.1 8.9 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family DUF4770 PF15994.5 EDK37317.2 - 7.4 6.8 15.2 20 5.4 10.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SpoIIP PF07454.11 EDK37317.2 - 8.3 5.8 16.8 1.8 8.0 8.2 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Inhibitor_I71 PF12628.7 EDK37317.2 - 8.9 6.1 8.3 2.8 7.8 0.6 2.2 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor HAD PF12710.7 EDK37318.2 - 2.3e-12 47.7 0.0 5.4e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EDK37318.2 - 3.3e-06 26.8 0.1 5.1e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EDK37318.2 - 0.0045 16.4 0.0 0.56 9.6 0.0 2.8 3 0 0 3 3 3 1 Putative Phosphatase DUF1896 PF08989.10 EDK37318.2 - 0.063 13.4 0.1 0.12 12.5 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1896) Peptidase_M20 PF01546.28 EDK37319.2 - 5.3e-22 78.5 2.0 1.2e-21 77.3 2.0 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK37319.2 - 1.5e-19 69.9 0.0 2.4e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDK37319.2 - 0.0018 18.0 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 DUF2373 PF10180.9 EDK37320.2 - 1.1e-22 79.6 0.6 2e-22 78.8 0.6 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Swm2 PF17083.5 EDK37320.2 - 0.0048 16.9 4.0 1.9 8.5 2.3 2.7 2 1 0 2 2 2 2 Nucleolar protein Swm2 TIP120 PF08623.10 EDK37321.2 - 5.8e-34 117.3 0.0 2.3e-33 115.3 0.0 2.2 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EDK37321.2 - 2.8e-08 34.0 0.8 6.2e-05 23.3 0.1 4.5 3 1 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EDK37321.2 - 4.5e-06 26.5 7.7 0.024 14.8 0.0 6.3 6 0 0 6 6 6 1 HEAT repeat RTP1_C1 PF10363.9 EDK37321.2 - 6.2e-05 23.1 0.9 0.0021 18.2 0.1 3.7 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EDK37321.2 - 0.0012 18.9 2.3 0.14 12.2 0.1 3.9 2 2 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDK37321.2 - 0.003 18.0 0.6 15 6.2 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat DNA_pol_B_palm PF14792.6 EDK37321.2 - 0.015 15.5 0.1 0.25 11.5 0.0 3.0 2 0 0 2 2 2 0 DNA polymerase beta palm Condensin2nSMC PF12422.8 EDK37321.2 - 0.039 14.1 0.2 0.61 10.3 0.0 3.1 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit ATP_bind_3 PF01171.20 EDK37321.2 - 0.065 13.0 0.5 4.1 7.1 0.1 2.6 2 0 0 2 2 2 0 PP-loop family Nop52 PF05997.12 EDK37321.2 - 0.36 10.6 1.8 41 3.9 0.0 4.1 4 1 0 4 4 4 0 Nucleolar protein,Nop52 Arm PF00514.23 EDK37321.2 - 0.49 10.5 2.0 13 6.0 0.0 3.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 EDK37321.2 - 2.4 8.2 13.8 3.1 7.9 1.4 5.2 5 0 0 5 5 5 0 Exportin 1-like protein Aconitase PF00330.20 EDK37322.2 - 4.9e-115 385.1 1.5 5.5e-114 381.7 1.5 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDK37322.2 - 1.3e-30 106.4 0.0 2.7e-30 105.4 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain GCV_T PF01571.21 EDK37322.2 - 0.044 13.1 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain DUF521 PF04412.13 EDK37322.2 - 0.052 12.3 0.0 0.083 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) CPBP PF02517.16 EDK37323.2 - 1.6e-15 57.3 1.9 1.6e-15 57.3 1.9 2.3 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease DUF1543 PF07566.12 EDK37324.2 - 0.097 12.4 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) Zds_C PF08632.10 EDK37325.2 - 2.1e-30 104.2 1.7 3.8e-30 103.4 1.7 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Cyt-b5 PF00173.28 EDK37326.1 - 5.2e-20 71.4 1.3 3.6e-19 68.7 0.1 2.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EDK37326.1 - 7.1e-14 52.3 19.5 1.4e-13 51.4 17.1 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily COX14 PF14880.6 EDK37326.1 - 0.59 10.0 2.9 27 4.7 1.1 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly RRN9 PF10680.9 EDK37327.2 - 6.3e-05 23.2 12.5 0.014 15.7 1.2 3.2 2 1 1 3 3 3 2 RNA polymerase I specific transcription initiation factor Macoilin PF09726.9 EDK37327.2 - 0.41 9.2 12.2 0.46 9.0 12.2 1.2 1 0 0 1 1 1 0 Macoilin family FAM163 PF15069.6 EDK37327.2 - 0.83 10.1 2.8 1.6 9.2 2.8 1.5 1 0 0 1 1 1 0 FAM163 family DUF4207 PF13904.6 EDK37327.2 - 3.3 7.3 18.2 0.21 11.3 12.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Pribosyltran PF00156.27 EDK37328.2 - 7.1e-19 67.9 0.1 9.6e-19 67.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SRP19 PF01922.17 EDK37329.1 - 3.1e-30 105.0 0.0 6.9e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 SRP19 protein DUF294_C PF10335.9 EDK37329.1 - 0.11 12.2 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain zf-C3HC PF07967.13 EDK37330.2 - 5e-38 130.1 6.6 2e-36 124.9 1.2 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like A2L_zn_ribbon PF08792.10 EDK37330.2 - 0.39 10.5 2.8 4.3 7.2 0.4 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain WD40 PF00400.32 EDK37331.2 - 8.2e-34 115.1 13.4 1.7e-06 28.7 0.2 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat CDC4_D PF16856.5 EDK37331.2 - 3.6e-18 65.2 1.8 1.2e-17 63.4 0.7 2.3 2 0 0 2 2 2 1 Cell division control protein 4 dimerisation domain ANAPC4_WD40 PF12894.7 EDK37331.2 - 1.9e-08 34.5 0.3 0.87 9.9 0.0 4.5 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 EDK37331.2 - 4.2e-07 29.8 0.1 9.2e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK37331.2 - 2.6e-06 27.1 0.0 6.2e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EDK37331.2 - 0.00076 18.3 5.8 0.22 10.1 0.1 4.7 3 1 2 5 5 5 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EDK37331.2 - 0.034 13.7 0.4 19 4.7 0.1 2.9 1 1 2 3 3 3 0 PQQ-like domain tRNA-synt_1 PF00133.22 EDK37332.2 - 1.8e-42 145.4 0.0 1e-32 113.2 0.0 2.6 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDK37332.2 - 1.7e-16 60.0 0.0 9.6e-09 34.5 0.0 3.2 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDK37332.2 - 1.9e-12 47.4 0.0 6.4e-12 45.7 0.0 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EDK37332.2 - 4.5e-08 32.8 0.0 1.1e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 EDK37332.2 - 0.0013 18.3 0.0 0.0051 16.3 0.0 2.0 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 DUF1857 PF08982.11 EDK37332.2 - 0.15 11.9 0.1 0.15 11.9 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1857) RRM_1 PF00076.22 EDK37333.2 - 5e-47 157.6 0.4 7.7e-15 54.5 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK37333.2 - 4.2e-13 48.9 0.0 4.4e-10 39.3 0.0 4.3 3 2 1 4 4 4 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDK37333.2 - 3.2e-09 36.7 0.0 0.0049 16.8 0.0 4.2 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 EDK37333.2 - 6.7e-08 32.4 0.1 1.1 9.3 0.0 4.8 3 2 1 4 4 4 3 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 EDK37333.2 - 0.013 15.3 0.0 0.92 9.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) NDUFA12 PF05071.16 EDK37333.2 - 0.2 12.5 2.9 1.1 10.1 1.7 2.7 2 1 1 3 3 3 0 NADH ubiquinone oxidoreductase subunit NDUFA12 G-patch PF01585.23 EDK37334.1 - 0.0043 16.9 1.2 0.0043 16.9 1.2 2.7 2 0 0 2 2 2 1 G-patch domain SLC12 PF03522.15 EDK37334.1 - 4.4 6.2 30.8 5.1 6.0 30.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PXA PF02194.15 EDK37335.2 - 6.8e-37 127.2 0.8 1.7e-36 125.9 0.8 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EDK37335.2 - 1.3e-21 77.2 0.0 4e-21 75.7 0.0 1.9 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EDK37335.2 - 7.6e-18 64.5 1.5 1e-17 64.1 0.2 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.19 EDK37335.2 - 0.00054 20.2 0.6 0.00054 20.2 0.6 3.3 4 0 0 4 4 4 1 Regulator of G protein signaling domain ABC_tran_CTD PF16326.5 EDK37335.2 - 0.32 11.3 2.7 1.6 9.1 2.7 2.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain MYO10_CC PF16735.5 EDK37335.2 - 0.87 9.7 5.0 19 5.5 0.9 2.6 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain WW PF00397.26 EDK37336.2 - 3.6e-10 39.7 1.1 6.7e-10 38.9 1.1 1.5 1 0 0 1 1 1 1 WW domain ETC_C1_NDUFA5 PF04716.14 EDK37337.2 - 6.5e-29 99.6 0.4 1.1e-28 98.8 0.4 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ras PF00071.22 EDK37339.2 - 3.2e-64 215.4 0.2 3.7e-64 215.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37339.2 - 2.6e-37 127.7 0.2 3.6e-37 127.2 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37339.2 - 5e-16 58.6 0.0 6.2e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK37339.2 - 1.7e-07 30.8 0.1 2.1e-07 30.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDK37339.2 - 5.5e-07 29.3 0.2 1.8e-06 27.6 0.1 1.7 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDK37339.2 - 3.1e-05 23.9 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDK37339.2 - 5.7e-05 23.2 0.0 9.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EDK37339.2 - 0.00018 21.0 0.0 0.00022 20.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDK37339.2 - 0.00089 18.8 0.0 0.0038 16.8 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EDK37339.2 - 0.0072 15.6 0.1 0.015 14.6 0.1 1.5 1 0 0 1 1 1 1 Septin AAA_7 PF12775.7 EDK37339.2 - 0.0091 15.5 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EDK37339.2 - 0.0092 16.3 0.1 0.15 12.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain CENP-M PF11111.8 EDK37339.2 - 0.032 13.4 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_16 PF13191.6 EDK37339.2 - 0.035 14.5 0.0 0.064 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EDK37339.2 - 0.058 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EDK37339.2 - 0.062 13.0 0.3 0.31 10.7 0.1 2.1 1 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 EDK37339.2 - 0.075 12.2 0.3 9.1 5.3 0.0 2.6 1 1 1 2 2 2 0 G-protein alpha subunit TniB PF05621.11 EDK37339.2 - 0.1 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein MCM PF00493.23 EDK37339.2 - 0.11 11.6 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain tRNA_synthFbeta PF17759.1 EDK37340.1 - 1.1e-39 136.1 0.0 1.6e-39 135.6 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EDK37340.1 - 1.5e-29 102.1 1.0 9.5e-28 96.3 0.2 2.6 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EDK37340.1 - 1.7e-27 96.2 0.0 3.6e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EDK37340.1 - 1.4e-20 73.4 0.1 3.4e-17 62.5 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF4989 PF16379.5 EDK37340.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4989) DUF726 PF05277.12 EDK37341.2 - 1.3e-126 422.2 3.0 1.8e-126 421.7 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) BpuJI_N PF11564.8 EDK37341.2 - 0.093 11.9 0.4 0.16 11.1 0.4 1.3 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal Methyltransf_34 PF11312.8 EDK37342.2 - 2.5e-93 312.7 0.2 3.7e-93 312.1 0.2 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Methyltransf_25 PF13649.6 EDK37342.2 - 0.11 13.2 0.0 0.28 11.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain SIR2 PF02146.17 EDK37343.2 - 3.4e-58 196.5 0.0 5.4e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Sir2 family CDC45 PF02724.14 EDK37343.2 - 0.081 11.2 4.6 0.086 11.1 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2070 PF09843.9 EDK37343.2 - 9.8 4.3 5.7 2 6.6 0.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) NFACT-C PF11923.8 EDK37344.2 - 2.7e-31 107.6 0.1 2.7e-31 107.6 0.1 4.9 5 0 0 5 5 5 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 EDK37344.2 - 8.3e-21 74.7 0.0 4.5e-20 72.3 0.0 2.3 2 0 0 2 2 2 1 NFACT protein RNA binding domain NESP55 PF06390.12 EDK37344.2 - 0.0049 16.5 6.8 0.0049 16.5 6.8 3.3 3 1 0 3 3 3 1 Neuroendocrine-specific golgi protein P55 (NESP55) NAM-associated PF14303.6 EDK37344.2 - 0.0096 16.7 12.3 0.0096 16.7 12.3 3.7 4 0 0 4 4 4 1 No apical meristem-associated C-terminal domain Trypan_PARP PF05887.11 EDK37344.2 - 0.15 12.0 11.7 1.9 8.5 4.0 2.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) His_Phos_2 PF00328.22 EDK37345.2 - 8.4e-47 160.3 0.0 9.9e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) B_lectin PF01453.24 EDK37345.2 - 0.12 13.0 0.0 0.43 11.1 0.0 1.9 2 0 0 2 2 2 0 D-mannose binding lectin PTR2 PF00854.21 EDK37346.1 - 1.8e-57 195.0 3.9 2.5e-57 194.5 3.9 1.1 1 0 0 1 1 1 1 POT family zf-like PF04071.12 EDK37346.1 - 0.01 15.7 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich small domain GST_C PF00043.25 EDK37347.2 - 4.8e-21 74.8 0.0 8.8e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDK37347.2 - 3e-18 65.9 0.0 6.1e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDK37347.2 - 5.7e-11 42.7 0.0 1.2e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDK37347.2 - 4e-10 39.9 0.0 8.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDK37347.2 - 0.00012 22.2 0.1 0.00042 20.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDK37347.2 - 0.029 14.4 0.0 0.066 13.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Tfb5 PF06331.12 EDK37348.2 - 0.11 12.6 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 MapZ_EC1 PF18041.1 EDK37348.2 - 0.55 10.5 9.8 0.71 10.1 4.6 2.6 2 0 0 2 2 2 0 MapZ extracellular domain 1 Lzipper-MIP1 PF14389.6 EDK37348.2 - 3.1 8.2 7.7 1.1 9.6 0.9 3.0 2 2 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Fzo_mitofusin PF04799.13 EDK37348.2 - 3.6 7.1 6.5 15 5.1 0.3 2.6 2 0 0 2 2 2 0 fzo-like conserved region Cyt-b5 PF00173.28 EDK37349.1 - 4e-10 39.7 0.0 4.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Flavi_M PF01004.19 EDK37349.1 - 0.18 11.6 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M U1snRNP70_N PF12220.8 EDK37350.2 - 4.1e-20 72.2 7.7 9.6e-20 71.0 7.7 1.6 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EDK37350.2 - 2e-16 59.5 0.0 4.3e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK37350.2 - 0.0012 18.9 0.0 0.006 16.7 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif DUF3752 PF12572.8 EDK37350.2 - 0.0035 17.9 1.5 0.0058 17.2 1.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3752) Ran_BP1 PF00638.18 EDK37351.2 - 1.6e-24 86.5 0.0 2.8e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Mucin PF01456.17 EDK37351.2 - 5.4 7.0 18.8 9.8 6.2 18.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Methyltransf_31 PF13847.6 EDK37352.2 - 5.7e-23 81.4 0.0 7.3e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK37352.2 - 7.8e-09 36.2 0.9 9.1e-09 36.0 0.1 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK37352.2 - 9.3e-09 35.9 0.0 1.7e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDK37352.2 - 6.9e-07 29.4 0.0 7.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK37352.2 - 3.7e-05 24.3 0.0 6.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK37352.2 - 0.00049 20.0 0.0 0.00057 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK37352.2 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 EDK37352.2 - 0.0098 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 EDK37352.2 - 0.035 13.5 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB IstB_IS21 PF01695.17 EDK37352.2 - 0.13 12.0 0.0 0.44 10.3 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein CAF1C_H4-bd PF12265.8 EDK37353.2 - 1.2e-22 79.9 0.1 4.7e-22 78.0 0.1 2.0 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDK37353.2 - 1.7e-11 44.5 23.5 0.00013 22.6 0.8 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37353.2 - 2e-11 44.0 1.6 0.01 16.1 0.1 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK37353.2 - 5.5e-07 29.6 1.0 0.00013 21.9 0.2 3.0 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 EDK37353.2 - 0.026 14.5 0.1 0.38 10.8 0.0 2.8 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Mt_ATP-synt_B PF05405.14 EDK37354.2 - 4.7e-49 166.1 10.4 5.9e-49 165.8 10.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Yuri_gagarin PF15934.5 EDK37354.2 - 8.7e-05 22.5 1.6 0.00011 22.1 1.6 1.1 1 0 0 1 1 1 1 Yuri gagarin DUF5623 PF18536.1 EDK37354.2 - 0.041 14.2 1.3 0.075 13.3 0.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5623) DivIC PF04977.15 EDK37354.2 - 0.11 12.2 0.4 0.11 12.2 0.4 2.1 1 1 1 2 2 2 0 Septum formation initiator SLATT_1 PF18181.1 EDK37354.2 - 4.5 7.2 9.0 0.083 12.8 1.7 1.9 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Abhydrolase_6 PF12697.7 EDK37355.2 - 2.4e-10 41.4 0.0 3.2e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDK37355.2 - 9.8e-08 31.9 0.1 1.5e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK37355.2 - 2.3e-06 27.1 0.1 3.8e-06 26.4 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EDK37355.2 - 0.00012 21.6 0.0 0.00021 20.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EDK37355.2 - 0.0022 17.7 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 EDK37355.2 - 0.0096 15.7 1.1 0.19 11.5 0.0 2.2 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase DUF2920 PF11144.8 EDK37355.2 - 0.041 13.0 0.1 0.062 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Palm_thioest PF02089.15 EDK37356.2 - 4.2e-78 262.5 0.0 4.8e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EDK37356.2 - 0.0016 18.0 0.0 0.0025 17.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EDK37356.2 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.16 EDK37356.2 - 0.026 14.3 0.1 3.7 7.3 0.1 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Adeno_E4 PF05385.11 EDK37356.2 - 0.032 14.3 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 Mastadenovirus early E4 13 kDa protein Lipase_2 PF01674.18 EDK37356.2 - 0.081 12.4 0.0 7.2 6.1 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 2) FSH1 PF03959.13 EDK37356.2 - 0.093 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Ribosomal_L1 PF00687.21 EDK37357.2 - 8e-42 143.3 4.0 1e-41 142.9 4.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family AA_permease_2 PF13520.6 EDK37358.2 - 2.1e-50 171.8 44.5 2.6e-50 171.5 44.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK37358.2 - 1.5e-33 116.1 41.6 2e-33 115.7 41.6 1.1 1 0 0 1 1 1 1 Amino acid permease Tim17 PF02466.19 EDK37359.1 - 8.9e-31 106.5 8.1 1.2e-30 106.1 8.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF3180 PF11377.8 EDK37359.1 - 5.3 7.2 9.5 36 4.5 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3180) Pkinase PF00069.25 EDK37361.2 - 5.7e-53 180.0 0.6 1.2e-51 175.6 0.6 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37361.2 - 8.2e-22 77.7 0.2 3.5e-21 75.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDK37361.2 - 0.00016 21.7 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDK37361.2 - 0.0075 15.9 0.3 0.0075 15.9 0.3 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EDK37361.2 - 0.011 15.1 0.4 0.059 12.7 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDK37361.2 - 0.011 15.3 0.1 0.011 15.3 0.1 1.8 2 0 0 2 2 2 0 RIO1 family RNA_pol_Rpb4 PF03874.16 EDK37362.2 - 1.9e-32 112.2 2.4 2.5e-32 111.8 2.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 GCV_T PF01571.21 EDK37362.2 - 0.033 13.6 0.0 0.059 12.7 0.0 1.4 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain NPA PF16469.5 EDK37362.2 - 0.055 14.1 0.1 0.095 13.3 0.1 1.4 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 EFTUD2 PF16004.5 EDK37363.2 - 3.4e-18 66.4 0.5 5.6e-18 65.7 0.5 1.3 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus GTP_EFTU PF00009.27 EDK37363.2 - 2.6e-11 43.5 0.0 3.8e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EDK37363.2 - 0.016 14.6 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 EDK37363.2 - 0.055 13.5 0.1 0.18 11.9 0.0 1.8 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 EDK37363.2 - 0.087 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase EFG_IV PF03764.18 EDK37364.2 - 6.5e-18 64.7 0.0 1.1e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EDK37364.2 - 3e-16 59.2 0.0 6.5e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDK37364.2 - 4.6e-08 33.3 1.4 6.8e-08 32.8 0.6 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDK37364.2 - 6.7e-05 22.9 0.0 0.00017 21.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF2420 PF10336.9 EDK37365.2 - 3.2e-31 107.5 2.0 3.2e-31 107.5 2.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2420) SWIRM PF04433.17 EDK37366.2 - 1.1e-31 109.0 0.1 3.4e-31 107.4 0.1 1.9 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EDK37366.2 - 7.2e-23 80.4 4.4 1.6e-22 79.3 4.4 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EDK37366.2 - 1.5e-10 41.0 0.2 3.2e-10 40.0 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK37366.2 - 2.5e-07 30.9 0.1 7.8e-07 29.3 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_L22 PF00237.19 EDK37367.1 - 7.6e-39 132.1 0.2 1.3e-38 131.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e UcrQ PF02939.16 EDK37368.1 - 7.8e-32 109.1 1.3 8.9e-32 108.9 1.3 1.0 1 0 0 1 1 1 1 UcrQ family DUF2794 PF10984.8 EDK37368.1 - 0.084 13.0 0.1 0.14 12.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2794) polyprenyl_synt PF00348.17 EDK37369.2 - 9.4e-89 296.8 0.0 1.2e-88 296.5 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Ebp2 PF05890.12 EDK37370.2 - 9.3e-89 297.5 24.2 9.3e-89 297.5 24.2 2.0 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Glyco_transf_15 PF01793.16 EDK37371.2 - 1.7e-108 362.7 3.3 2.1e-108 362.4 3.3 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase MFS_1 PF07690.16 EDK37371.2 - 0.26 10.2 0.0 0.33 9.8 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Complex1_51K PF01512.17 EDK37372.2 - 1.4e-46 158.1 0.0 1.9e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit DUF3568 PF12092.8 EDK37372.2 - 0.034 14.2 0.9 0.078 13.0 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) NADH_4Fe-4S PF10589.9 EDK37373.2 - 1.2e-30 105.4 0.2 2.3e-30 104.5 0.2 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EDK37373.2 - 4.4e-06 26.5 0.0 9.5e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 SLBB domain UPF0016 PF01169.19 EDK37375.1 - 3.9e-41 139.2 23.5 2e-20 72.8 8.8 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Presenilin PF01080.17 EDK37375.1 - 0.00044 19.1 0.7 0.00077 18.3 0.7 1.3 1 0 0 1 1 1 1 Presenilin TerC PF03741.16 EDK37375.1 - 1.5 8.5 12.3 0.085 12.5 4.1 2.4 1 1 1 2 2 2 0 Integral membrane protein TerC family Med8 PF10232.9 EDK37376.1 - 2.4e-17 63.3 2.1 3.3e-17 62.9 2.1 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Cnd1_N PF12922.7 EDK37376.1 - 0.0094 15.8 0.8 0.75 9.6 0.1 2.2 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1, N-term Allexi_40kDa PF05549.11 EDK37376.1 - 0.049 13.2 0.1 0.076 12.5 0.1 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein NpwBP PF12622.7 EDK37377.1 - 9.9e-08 32.6 6.5 4.2e-07 30.6 6.5 2.3 1 1 0 1 1 1 1 mRNA biogenesis factor Wbp11 PF09429.10 EDK37377.1 - 0.00095 19.5 11.2 0.00095 19.5 11.2 2.1 2 0 0 2 2 2 1 WW domain binding protein 11 EcoEI_R_C PF08463.10 EDK37377.1 - 0.023 14.8 2.1 0.033 14.3 2.1 1.3 1 0 0 1 1 1 0 EcoEI R protein C-terminal Mito_carr PF00153.27 EDK37378.1 - 2.5e-75 248.5 1.4 3.7e-27 94.1 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PrcB_C PF14343.6 EDK37378.1 - 0.15 12.2 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 PrcB C-terminal DUF3535 PF12054.8 EDK37379.2 - 7.5e-122 407.7 4.2 7.5e-122 407.7 4.2 3.4 5 0 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EDK37379.2 - 1.6e-63 214.5 0.1 1.1e-62 211.8 0.0 2.2 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK37379.2 - 4.3e-19 68.9 0.1 5.7e-18 65.3 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 EDK37379.2 - 7.6e-14 50.6 8.8 0.12 12.7 0.0 10.2 10 1 0 10 10 10 3 HEAT repeat Vac14_Fab1_bd PF12755.7 EDK37379.2 - 4.1e-07 30.5 0.1 0.019 15.5 0.0 4.4 5 0 0 5 5 4 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EDK37379.2 - 4.1e-06 27.2 7.5 5.5 7.6 0.0 8.6 9 0 0 9 9 9 1 HEAT-like repeat HEAT_2 PF13646.6 EDK37379.2 - 0.00012 22.4 2.5 0.37 11.2 0.0 5.8 7 0 0 7 7 7 1 HEAT repeats TAF6_C PF07571.13 EDK37379.2 - 0.0041 17.4 0.1 35 4.8 0.0 5.1 4 1 1 5 5 5 0 TAF6 C-terminal HEAT repeat domain ERCC3_RAD25_C PF16203.5 EDK37379.2 - 0.051 12.8 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF3385 PF11865.8 EDK37379.2 - 0.056 13.4 0.1 0.9 9.4 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) DUF3450 PF11932.8 EDK37379.2 - 0.2 10.9 2.0 1.6 8.0 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) MetOD2 PF18548.1 EDK37379.2 - 0.86 9.7 4.0 22 5.2 0.0 3.5 3 0 0 3 3 3 0 Metanogen output domain 2 Ccdc124 PF06244.12 EDK37380.1 - 2e-30 106.0 23.5 2e-30 106.0 23.5 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 ADH_N PF08240.12 EDK37381.2 - 3.2e-26 91.3 0.7 5.8e-26 90.5 0.7 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK37381.2 - 8e-17 61.4 0.0 1.5e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDK37381.2 - 5.2e-09 37.2 0.0 7.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDK37381.2 - 6.1e-05 22.4 0.0 0.0001 21.6 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_11 PF08241.12 EDK37381.2 - 0.00067 20.3 0.0 0.0024 18.5 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain 2-Hacid_dh_C PF02826.19 EDK37381.2 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.20 EDK37381.2 - 0.0088 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Methyltransf_25 PF13649.6 EDK37381.2 - 0.018 15.7 0.0 0.064 14.0 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain ThiF PF00899.21 EDK37381.2 - 0.087 12.2 0.3 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 ThiF family adh_short PF00106.25 EDK37381.2 - 0.097 12.1 0.0 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase 3HCDH_N PF02737.18 EDK37381.2 - 0.2 11.5 0.4 0.39 10.6 0.0 1.7 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HMGL-like PF00682.19 EDK37382.2 - 6.4e-84 281.6 0.4 8.7e-84 281.2 0.4 1.2 1 0 0 1 1 1 1 HMGL-like TMF_TATA_bd PF12325.8 EDK37383.2 - 1 9.6 6.0 4.3 7.6 1.9 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Mur_ligase_M PF08245.12 EDK37384.2 - 0.00013 22.0 0.0 0.0028 17.7 0.0 2.7 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EDK37384.2 - 0.0037 17.5 0.0 0.051 13.8 0.0 2.4 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain DUF1798 PF08807.10 EDK37385.2 - 0.028 14.6 1.4 0.34 11.1 0.0 3.0 3 0 0 3 3 3 0 Bacterial domain of unknown function (DUF1798) DUF2513 PF10711.9 EDK37385.2 - 0.037 14.3 0.1 18 5.7 0.0 2.8 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) DASH_Dad2 PF08654.10 EDK37385.2 - 0.49 10.9 3.4 19 5.8 0.4 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad2 Pkinase PF00069.25 EDK37386.2 - 1.4e-65 221.3 0.3 2.3e-65 220.6 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37386.2 - 3.3e-38 131.4 0.1 5.2e-38 130.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK37386.2 - 2.5e-06 27.0 0.0 4.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK37386.2 - 0.00075 18.9 0.1 0.0035 16.7 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDK37386.2 - 0.01 14.7 0.0 0.01 14.7 0.0 2.3 2 1 1 3 3 3 1 Fungal protein kinase PB1-F2 PF11986.8 EDK37386.2 - 0.39 10.9 3.2 1.5 9.1 0.1 3.1 3 0 0 3 3 3 0 Influenza A Proapoptotic protein SUV3_C PF12513.8 EDK37387.2 - 2.6e-14 52.9 0.6 6.1e-14 51.7 0.6 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EDK37387.2 - 4.4e-14 52.8 0.2 3.3e-13 50.0 0.0 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain SKI PF01202.22 EDK37388.2 - 1.1e-10 41.8 0.0 1.5e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 EDK37388.2 - 2.6e-07 31.2 0.0 6.8e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EDK37388.2 - 4.3e-06 26.6 0.0 0.00057 19.7 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase APS_kinase PF01583.20 EDK37388.2 - 1e-05 25.5 0.0 1.4e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EDK37388.2 - 5.5e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDK37388.2 - 0.0016 18.7 0.0 0.006 16.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EDK37388.2 - 0.0026 18.2 0.2 0.0034 17.8 0.2 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 EDK37388.2 - 0.0038 16.9 0.0 0.41 10.3 0.0 2.3 2 1 0 2 2 2 1 Thymidylate kinase AAA_17 PF13207.6 EDK37388.2 - 0.0074 16.7 0.0 0.014 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDK37388.2 - 0.0086 16.3 0.1 0.03 14.6 0.1 1.7 1 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK37388.2 - 0.011 16.2 0.0 0.016 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EDK37388.2 - 0.011 15.2 0.3 0.016 14.7 0.3 1.2 1 0 0 1 1 1 0 PhoH-like protein CPT PF07931.12 EDK37388.2 - 0.011 15.6 0.0 0.43 10.4 0.0 2.1 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.6 EDK37388.2 - 0.013 15.2 0.3 0.02 14.6 0.3 1.2 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 EDK37388.2 - 0.014 15.3 0.1 0.13 12.1 0.0 2.0 1 1 0 2 2 2 0 Deoxynucleoside kinase Zeta_toxin PF06414.12 EDK37388.2 - 0.015 14.6 0.0 0.031 13.5 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EDK37388.2 - 0.022 14.5 0.0 0.031 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDK37388.2 - 0.039 14.5 0.1 0.059 13.9 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 EDK37388.2 - 0.049 13.6 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CoaE PF01121.20 EDK37388.2 - 0.059 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_25 PF13481.6 EDK37388.2 - 0.062 12.9 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EDK37388.2 - 0.069 12.2 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 EDK37388.2 - 0.08 13.3 0.3 0.17 12.2 0.3 1.5 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EDK37388.2 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 EDK37388.2 - 0.086 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EDK37388.2 - 0.089 12.0 0.1 0.12 11.6 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EDK37388.2 - 0.18 11.7 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain GSK-3_bind PF05350.12 EDK37388.2 - 0.19 11.0 0.0 6.4 6.0 0.0 2.3 2 1 0 2 2 2 0 Glycogen synthase kinase-3 binding adh_short PF00106.25 EDK37389.2 - 1.2e-18 67.2 0.0 4.4e-15 55.6 0.0 3.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK37389.2 - 5.2e-08 32.7 0.0 2.2e-06 27.4 0.0 2.6 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK37389.2 - 0.082 12.8 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 KR domain DUF1776 PF08643.10 EDK37389.2 - 0.14 11.5 0.2 0.48 9.7 0.2 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) SGT1 PF07093.11 EDK37390.2 - 8.9e-20 70.6 0.9 8.9e-20 70.6 0.9 2.0 2 0 0 2 2 2 1 SGT1 protein Thiolase_N PF00108.23 EDK37391.2 - 5e-93 311.2 1.7 7.2e-93 310.7 1.7 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDK37391.2 - 2.7e-46 156.2 0.4 6.6e-46 155.0 0.4 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDK37391.2 - 0.00021 21.0 0.1 0.0006 19.5 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EDK37391.2 - 0.085 12.7 1.2 7.1 6.6 0.1 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 EDK37392.2 - 9.3e-27 93.9 40.1 9.3e-27 93.9 40.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily FLILHELTA PF10306.9 EDK37393.2 - 8.5e-30 103.0 0.3 1.7e-29 102.1 0.3 1.5 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA Pkinase PF00069.25 EDK37394.2 - 1.2e-63 215.0 0.0 1.4e-63 214.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37394.2 - 1.1e-22 80.5 0.0 1.4e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDK37394.2 - 0.00052 20.0 0.0 0.0052 16.7 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK37394.2 - 0.0041 16.5 0.0 0.014 14.7 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Choline_kinase PF01633.20 EDK37394.2 - 0.016 14.8 0.1 0.031 13.9 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 EDK37394.2 - 0.016 14.8 0.0 0.048 13.3 0.0 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDK37394.2 - 0.05 13.0 0.1 0.087 12.2 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDK37394.2 - 0.13 11.0 0.0 5.7 5.6 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF1682 PF07946.14 EDK37395.2 - 1.1 8.5 16.6 2 7.5 16.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DDRGK PF09756.9 EDK37395.2 - 1.1 8.8 26.2 2.3 7.8 26.2 1.5 1 0 0 1 1 1 0 DDRGK domain DUF4407 PF14362.6 EDK37395.2 - 4.2 6.6 11.5 6.7 6.0 11.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RPN2_C PF18004.1 EDK37395.2 - 9.9 6.1 18.0 0.93 9.4 11.5 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pkinase PF00069.25 EDK37396.2 - 1.2e-33 116.6 0.0 1.5e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37396.2 - 3.8e-18 65.7 0.0 5e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK37396.2 - 0.0031 16.9 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Herpes_UL33 PF03581.13 EDK37396.2 - 0.048 14.0 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL33-like protein Pkinase PF00069.25 EDK37397.2 - 3.8e-62 210.1 0.1 5.4e-62 209.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37397.2 - 1.1e-31 110.1 0.5 4.4e-30 104.8 0.5 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK37397.2 - 0.00055 19.0 0.1 0.00081 18.4 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Imm7 PF15585.6 EDK37397.2 - 0.002 18.4 0.0 0.0062 16.8 0.0 1.8 2 0 0 2 2 2 1 Immunity protein 7 Kinase-like PF14531.6 EDK37397.2 - 0.0066 15.8 0.1 0.012 14.9 0.1 1.5 1 1 0 1 1 1 1 Kinase-like N1221 PF07923.13 EDK37397.2 - 0.087 12.0 0.0 4.4 6.4 0.0 2.3 2 0 0 2 2 2 0 N1221-like protein Porphobil_deam PF01379.20 EDK37399.2 - 8e-72 241.0 0.0 1.1e-71 240.6 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EDK37399.2 - 1.3e-21 76.7 0.0 2.5e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF188 PF02639.14 EDK37399.2 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 FXR_C1 PF16096.5 EDK37400.2 - 0.036 14.3 0.1 0.036 14.3 0.1 2.0 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Glyco_hydro_2_C PF02836.17 EDK37400.2 - 0.058 12.5 0.2 3.1 6.8 0.0 2.1 1 1 1 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain ERCC4 PF02732.15 EDK37401.2 - 1.6e-20 73.9 0.0 6e-20 72.0 0.0 2.1 1 0 0 1 1 1 1 ERCC4 domain RMI1_N PF08585.12 EDK37402.1 - 1.9e-11 44.2 0.0 2.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 RecQ mediated genome instability protein MTHFR PF02219.17 EDK37403.2 - 5.5e-104 347.5 0.0 8.8e-104 346.8 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ATG27 PF09451.10 EDK37404.2 - 2.8e-62 211.0 1.1 3.4e-62 210.7 1.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EDK37404.2 - 1.2e-06 28.7 1.6 0.00014 21.9 0.2 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF2165 PF09933.9 EDK37404.2 - 0.018 15.1 0.2 0.027 14.5 0.2 1.3 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) Ldh_1_N PF00056.23 EDK37405.2 - 2.1e-43 147.8 0.9 2.9e-43 147.3 0.9 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EDK37405.2 - 6.3e-35 120.6 0.0 1.3e-34 119.6 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EDK37405.2 - 0.1 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Beta-lactamase PF00144.24 EDK37406.2 - 7.4e-41 140.5 0.0 1.2e-40 139.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Histidinol_dh PF00815.20 EDK37407.2 - 4e-156 520.1 3.8 7.3e-156 519.3 3.8 1.4 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EDK37407.2 - 5.2e-20 71.0 0.4 1.4e-19 69.7 0.4 1.7 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EDK37407.2 - 1.1e-13 51.4 0.1 2.9e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 EDK37407.2 - 0.033 14.4 0.3 0.073 13.3 0.3 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain TPR_1 PF00515.28 EDK37408.2 - 3.6e-22 77.2 2.9 7.3e-06 25.6 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDK37408.2 - 3.2e-19 68.3 0.6 5e-06 26.1 0.0 5.1 3 1 2 5 5 5 3 TPR repeat TPR_2 PF07719.17 EDK37408.2 - 2.2e-17 61.7 5.7 0.0017 18.4 0.0 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EDK37408.2 - 3.4e-16 58.4 1.7 0.0032 17.7 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37408.2 - 5.6e-15 54.8 0.6 0.0055 17.4 0.0 5.5 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK37408.2 - 1.9e-14 52.6 5.4 0.014 15.5 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDK37408.2 - 6e-13 49.1 2.5 0.0048 17.4 0.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDK37408.2 - 2.9e-10 40.6 0.0 0.0096 16.6 0.0 4.3 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDK37408.2 - 1.7e-08 34.5 0.0 0.0013 18.8 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_20 PF14561.6 EDK37408.2 - 3.3e-08 33.7 0.6 0.0075 16.6 0.0 4.4 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDK37408.2 - 0.0002 21.6 0.2 0.13 12.6 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK37408.2 - 0.00045 19.5 0.3 0.94 8.6 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK37408.2 - 0.0005 20.2 3.6 0.17 12.1 0.2 3.6 2 2 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDK37408.2 - 0.0024 17.8 0.0 6.4 7.0 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK37408.2 - 0.0073 16.9 1.9 1.2e+02 3.6 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat AChE_tetra PF08674.10 EDK37408.2 - 4.5 7.1 6.2 15 5.4 0.2 3.0 3 0 0 3 3 2 0 Acetylcholinesterase tetramerisation domain Ring_hydroxyl_A PF00848.19 EDK37409.2 - 8.1e-28 97.8 0.1 1.3e-27 97.1 0.1 1.3 1 0 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EDK37409.2 - 4e-15 55.5 0.0 8.9e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain ARID PF01388.21 EDK37410.2 - 1.9e-14 54.1 1.8 4.9e-14 52.8 0.0 2.7 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Glyco_transf_34 PF05637.12 EDK37411.2 - 8.5e-70 235.2 0.2 1.1e-69 234.8 0.2 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Pex2_Pex12 PF04757.14 EDK37412.2 - 3.3e-18 66.1 1.5 4.3e-18 65.7 1.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 EDK37412.2 - 4.2e-09 36.6 10.3 6.3e-09 36.0 10.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK37412.2 - 1.2e-07 31.5 9.9 1.8e-07 30.9 9.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK37412.2 - 1.2e-07 31.5 10.4 1.6e-07 31.1 10.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK37412.2 - 7.1e-07 29.0 8.6 1.1e-06 28.3 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK37412.2 - 4.2e-06 26.7 3.6 4.2e-06 26.7 3.6 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EDK37412.2 - 1.5e-05 25.2 8.4 2.5e-05 24.5 8.4 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EDK37412.2 - 2e-05 24.3 11.1 3e-05 23.8 11.1 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDK37412.2 - 7.9e-05 22.7 8.6 0.00015 21.9 8.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EDK37412.2 - 0.00054 19.9 5.8 0.00097 19.1 5.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EDK37412.2 - 0.012 15.7 6.5 0.023 14.8 6.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EDK37412.2 - 0.43 10.7 6.5 0.67 10.1 6.5 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger YdjO PF14169.6 EDK37412.2 - 4.3 7.1 7.3 15 5.4 1.8 2.5 2 0 0 2 2 2 0 Cold-inducible protein YdjO IMS PF00817.20 EDK37413.2 - 2.3e-44 151.0 0.0 3.6e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EDK37413.2 - 8.6e-06 25.2 1.6 1.7e-05 24.3 1.6 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 EDK37413.2 - 0.07 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif Ferric_reduct PF01794.19 EDK37414.2 - 1e-17 64.4 20.1 2.3e-17 63.3 12.8 2.6 2 0 0 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDK37414.2 - 2.3e-13 50.6 0.1 3.9e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDK37414.2 - 6.2e-06 26.3 0.2 1.3e-05 25.2 0.2 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EDK37414.2 - 0.11 13.2 0.0 0.85 10.3 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF2070 PF09843.9 EDK37414.2 - 0.57 8.4 14.7 0.83 7.9 14.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ada_Zn_binding PF02805.16 EDK37415.2 - 3.2e-20 71.9 3.5 6.3e-20 71.0 3.5 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 EDK37415.2 - 0.0011 19.0 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EDK37415.2 - 0.0014 18.9 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain VitD-bind_III PF09164.10 EDK37415.2 - 0.1 12.6 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Vitamin D binding protein, domain III NmrA PF05368.13 EDK37416.2 - 3e-10 40.1 0.3 3.9e-10 39.7 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EDK37416.2 - 0.018 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Tti2 PF10521.9 EDK37416.2 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Tti2 family DUF166 PF02593.14 EDK37416.2 - 0.094 12.2 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function Pkinase PF00069.25 EDK37417.2 - 3.2e-71 239.8 0.0 4.6e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37417.2 - 1.6e-39 135.8 0.0 2.2e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK37417.2 - 3.3e-07 29.9 0.0 9.7e-06 25.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDK37417.2 - 0.0022 16.8 0.1 0.0053 15.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EDK37417.2 - 0.013 14.8 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aminotran_3 PF00202.21 EDK37418.2 - 6.5e-107 357.7 0.0 7.4e-107 357.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDK37418.2 - 0.062 12.5 0.0 0.098 11.8 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Longin_2 PF18639.1 EDK37419.2 - 6.1e-11 42.5 0.2 6.9e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Yeast longin domain FAST_1 PF06743.15 EDK37419.2 - 0.06 13.3 0.2 0.37 10.8 0.0 2.4 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 SRI PF08236.11 EDK37420.2 - 3.5e-26 91.2 3.5 3.5e-26 91.2 3.5 2.5 3 0 0 3 3 3 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EDK37420.2 - 5.9e-17 62.6 0.3 5.9e-17 62.6 0.3 4.0 3 2 0 3 3 3 1 SET domain AWS PF17907.1 EDK37420.2 - 4.1e-14 52.3 10.4 4.1e-14 52.3 10.4 2.5 2 0 0 2 2 2 1 AWS domain WW PF00397.26 EDK37420.2 - 1.5e-07 31.4 0.2 3e-07 30.4 0.2 1.6 1 0 0 1 1 1 1 WW domain Med26 PF08711.11 EDK37420.2 - 0.00014 21.8 3.1 0.00014 21.8 3.1 2.6 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Peptidase_S46 PF10459.9 EDK37420.2 - 2.9 6.4 18.7 5.7 5.5 18.7 1.4 1 0 0 1 1 1 0 Peptidase S46 NAD_Gly3P_dh_N PF01210.23 EDK37421.1 - 2.4e-52 177.1 0.0 3.5e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDK37421.1 - 2.8e-43 147.6 0.2 7.5e-43 146.2 0.1 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EDK37421.1 - 0.00086 19.8 0.0 0.81 10.3 0.0 2.7 3 0 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EDK37421.1 - 0.03 14.7 0.0 0.13 12.7 0.0 2.0 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain zf-C2H2 PF00096.26 EDK37422.2 - 1.6e-11 44.0 6.4 6e-05 23.3 0.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK37422.2 - 1.2e-09 38.1 6.0 0.00061 20.4 0.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK37422.2 - 7.8e-06 26.0 4.3 0.094 13.0 2.3 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EDK37422.2 - 0.0017 18.7 6.2 0.0025 18.2 0.7 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDK37422.2 - 0.0019 18.1 6.7 0.063 13.3 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EDK37422.2 - 0.0026 17.4 1.6 0.22 11.2 0.2 2.4 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-met PF12874.7 EDK37422.2 - 0.0037 17.6 1.2 0.62 10.5 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EDK37422.2 - 0.0042 16.8 5.8 0.35 10.7 3.7 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 EDK37422.2 - 0.013 15.4 2.1 2.2 8.2 0.8 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 EDK37422.2 - 0.014 15.8 5.1 3.4 8.2 5.1 2.7 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 EDK37422.2 - 0.018 15.7 1.1 0.55 10.9 0.4 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 EDK37422.2 - 0.024 14.2 3.1 0.8 9.4 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_8 PF15909.5 EDK37422.2 - 0.028 14.7 0.7 0.07 13.4 0.7 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon DZR PF12773.7 EDK37422.2 - 0.053 13.5 0.5 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2_11 PF16622.5 EDK37422.2 - 0.062 13.1 3.3 0.42 10.4 0.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-MYST PF17772.1 EDK37422.2 - 0.11 12.1 0.4 4 7.1 0.1 2.5 2 0 0 2 2 2 0 MYST family zinc finger domain LIM PF00412.22 EDK37422.2 - 0.35 11.1 4.2 0.96 9.7 3.9 1.8 1 1 0 1 1 1 0 LIM domain PHD PF00628.29 EDK37422.2 - 0.69 9.8 3.0 7.3 6.6 0.2 2.3 1 1 1 2 2 2 0 PHD-finger ING PF12998.7 EDK37423.2 - 1.2e-25 90.1 0.1 2.2e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDK37423.2 - 3.5e-05 23.6 6.8 6.8e-05 22.7 6.8 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EDK37423.2 - 0.027 14.7 0.3 0.069 13.4 0.3 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EDK37423.2 - 0.04 13.5 1.6 0.077 12.6 1.6 1.5 1 0 0 1 1 1 0 PHD-finger Presenilin PF01080.17 EDK37423.2 - 7.9 5.1 7.4 11 4.6 7.4 1.1 1 0 0 1 1 1 0 Presenilin Ras PF00071.22 EDK37424.2 - 1.7e-45 154.6 0.1 2e-45 154.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37424.2 - 3.8e-22 78.7 0.0 4.8e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37424.2 - 4.1e-10 39.4 0.0 4.8e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK37424.2 - 8.2e-06 25.5 0.1 7.4e-05 22.4 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK37424.2 - 7e-05 22.9 0.0 8.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37424.2 - 0.0033 17.4 0.2 0.66 9.9 0.0 2.8 2 1 1 3 3 3 1 RsgA GTPase Gtr1_RagA PF04670.12 EDK37424.2 - 0.023 14.0 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EDK37424.2 - 0.049 14.0 0.0 2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 EDK37424.2 - 0.084 12.4 0.1 0.18 11.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EDK37424.2 - 0.1 11.9 0.0 0.21 10.8 0.0 1.6 1 1 0 1 1 1 0 Septin ParA PF10609.9 EDK37424.2 - 0.15 11.5 0.1 0.2 11.1 0.1 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_22 PF13401.6 EDK37424.2 - 0.16 12.3 0.1 0.41 10.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 EDK37424.2 - 0.32 11.1 1.5 1.2 9.2 1.5 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DAD PF02109.16 EDK37425.1 - 2.9e-44 149.8 1.4 3.8e-44 149.5 1.4 1.1 1 0 0 1 1 1 1 DAD family Y_phosphatase2 PF03162.13 EDK37427.2 - 1.7e-49 167.6 0.0 2e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDK37427.2 - 8.2e-08 32.5 0.0 1.5e-07 31.7 0.0 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EDK37427.2 - 0.00098 19.0 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain VCX_VCY PF15231.6 EDK37428.2 - 0.023 15.4 0.5 0.066 13.9 0.9 1.5 2 0 0 2 2 2 0 Variable charge X/Y family GSHPx PF00255.19 EDK37429.2 - 3.3e-48 161.8 0.5 4.5e-48 161.3 0.5 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EDK37429.2 - 5.4e-06 26.3 0.2 1.2e-05 25.2 0.2 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK37429.2 - 8.6e-06 25.5 0.1 3.4e-05 23.6 0.1 1.8 1 1 0 1 1 1 1 Redoxin Pkinase PF00069.25 EDK37430.2 - 1.3e-48 165.7 0.1 1.6e-48 165.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37430.2 - 7.1e-29 100.9 0.0 9.7e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK37430.2 - 0.00028 20.3 0.0 0.013 14.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK37430.2 - 0.0017 17.4 0.7 0.01 14.8 0.0 2.3 3 0 0 3 3 3 1 Haspin like kinase domain APH PF01636.23 EDK37430.2 - 0.023 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EDK37430.2 - 0.12 12.0 0.0 0.39 10.3 0.0 1.9 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 IlvN PF07991.12 EDK37431.2 - 1.9e-44 151.2 0.0 2.6e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EDK37431.2 - 5.7e-16 59.1 0.2 1.4e-15 57.8 0.1 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain VASt PF16016.5 EDK37432.2 - 1.3e-35 123.1 2.6 1.4e-35 122.9 0.3 2.2 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDK37432.2 - 2.4e-26 91.8 0.1 7.7e-26 90.2 0.0 1.8 2 0 0 2 2 2 1 GRAM domain Baculo_11_kDa PF06143.11 EDK37432.2 - 0.0012 18.4 0.9 0.003 17.1 0.9 1.6 1 0 0 1 1 1 1 Baculovirus 11 kDa family MMU163 PF17119.5 EDK37433.2 - 7.9e-18 64.5 0.1 9.9e-18 64.2 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis 6PF2K PF01591.18 EDK37434.2 - 5.3e-77 258.1 0.0 1.4e-76 256.7 0.0 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDK37434.2 - 5.7e-31 107.7 0.0 2.9e-23 82.6 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDK37434.2 - 0.0031 17.7 0.0 0.014 15.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDK37434.2 - 0.044 13.2 0.0 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Vac7 PF12751.7 EDK37435.2 - 1.3e-37 130.2 19.8 7.4e-19 68.4 0.0 3.2 2 1 0 3 3 3 3 Vacuolar segregation subunit 7 p450 PF00067.22 EDK37436.2 - 9.5e-48 163.1 0.2 2.2e-47 161.9 0.2 1.5 1 1 0 1 1 1 1 Cytochrome P450 bZIP_1 PF00170.21 EDK37436.2 - 0.072 13.2 0.3 0.2 11.8 0.3 1.7 1 0 0 1 1 1 0 bZIP transcription factor muHD PF10291.9 EDK37437.2 - 9.7e-53 179.3 0.1 1.7e-52 178.5 0.1 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Ribosomal_S19 PF00203.21 EDK37437.2 - 0.076 12.9 0.1 10 6.1 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S19 Ammonium_transp PF00909.21 EDK37438.2 - 1.1e-121 406.4 28.4 1.2e-121 406.2 28.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family UPF0183 PF03676.14 EDK37439.2 - 4e-56 191.0 0.2 4.9e-56 190.7 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) LRR_9 PF14580.6 EDK37440.2 - 3.4e-40 137.4 0.6 4.8e-40 136.9 0.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EDK37440.2 - 0.00016 21.9 6.1 0.41 11.1 0.2 3.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) GA PF01468.17 EDK37440.2 - 0.024 14.9 2.1 0.027 14.7 0.3 2.0 2 0 0 2 2 2 0 GA module BAH PF01426.18 EDK37441.2 - 4.9e-15 55.5 0.1 1.7e-14 53.7 0.1 2.0 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 EDK37441.2 - 1.1e-09 38.0 28.9 3.5e-07 30.0 12.2 6.8 6 0 0 6 6 6 3 PHD-finger zf-HC5HC2H PF13771.6 EDK37441.2 - 0.00012 22.2 2.0 0.00012 22.2 2.0 5.9 3 2 1 5 5 5 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EDK37441.2 - 0.00037 20.0 1.4 0.00037 20.0 1.4 5.7 6 0 0 6 6 6 2 PHD-finger mRNA_cap_enzyme PF01331.19 EDK37442.2 - 3.8e-54 183.5 0.0 5.4e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDK37442.2 - 4.3e-33 114.2 0.2 8.4e-33 113.2 0.2 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDK37442.2 - 8e-06 25.6 0.0 0.047 13.3 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain FMO-like PF00743.19 EDK37443.2 - 6.8e-32 110.6 0.2 4e-13 48.6 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EDK37443.2 - 3.1e-09 36.4 0.7 0.00022 20.5 0.1 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDK37443.2 - 3.2e-09 36.5 4.1 9.6e-06 25.1 1.8 3.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDK37443.2 - 2.1e-08 33.7 0.0 2.9e-07 30.0 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK37443.2 - 8.2e-06 25.9 0.2 9.2e-05 22.5 0.1 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EDK37443.2 - 0.00018 21.7 0.0 0.00051 20.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDK37443.2 - 0.01 16.3 0.0 0.13 12.9 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDK37443.2 - 0.029 13.6 0.1 0.12 11.6 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 EDK37443.2 - 0.057 13.5 0.0 0.28 11.3 0.0 2.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 EDK37443.2 - 0.15 12.0 0.0 0.56 10.2 0.0 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Prefoldin_2 PF01920.20 EDK37444.1 - 1.1e-16 60.7 11.1 1.2e-16 60.5 11.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Sec2p PF06428.11 EDK37444.1 - 0.0024 17.8 0.5 0.0024 17.8 0.5 2.0 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Osmo_CC PF08946.10 EDK37444.1 - 0.12 12.6 0.8 0.12 12.6 0.8 2.7 2 1 1 3 3 3 0 Osmosensory transporter coiled coil PBECR5 PF18814.1 EDK37444.1 - 0.12 12.3 4.9 0.14 12.1 4.9 1.0 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 Cob_adeno_trans PF01923.18 EDK37444.1 - 0.2 11.8 1.7 0.32 11.1 1.6 1.4 1 1 0 1 1 1 0 Cobalamin adenosyltransferase PhoU PF01895.19 EDK37444.1 - 0.4 11.2 4.5 0.19 12.2 1.0 2.1 1 1 1 2 2 2 0 PhoU domain TraF_2 PF13729.6 EDK37444.1 - 0.98 8.7 6.4 13 5.0 6.4 2.0 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein Spc24 PF08286.11 EDK37444.1 - 1.1 9.5 9.2 3.6 7.9 3.4 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Mis14 PF08641.12 EDK37444.1 - 1.1 9.6 8.6 0.19 12.0 1.6 2.4 1 1 0 2 2 2 0 Kinetochore protein Mis14 like DUF4094 PF13334.6 EDK37444.1 - 1.6 9.2 5.7 0.66 10.4 2.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Syntaxin-6_N PF09177.11 EDK37444.1 - 2.2 8.9 8.0 9.1 6.9 1.2 2.2 1 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF4140 PF13600.6 EDK37444.1 - 4.1 7.9 7.8 1.5e+02 2.9 7.8 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Acetyltransf_1 PF00583.25 EDK37445.2 - 1.7e-08 34.7 0.0 0.001 19.3 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EDK37445.2 - 1.9e-06 28.0 0.0 9e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK37445.2 - 5.5e-05 23.5 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK37445.2 - 0.026 14.5 0.1 0.1 12.5 0.0 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK37445.2 - 0.027 14.6 0.0 0.076 13.2 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 EDK37445.2 - 0.097 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Glutaredoxin PF00462.24 EDK37446.1 - 1.9e-17 63.2 0.0 2.6e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EDK37446.1 - 0.00047 20.6 0.1 0.00072 20.0 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DUF836 PF05768.14 EDK37446.1 - 0.00099 19.5 0.1 0.0013 19.1 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 EDK37446.1 - 0.0016 18.2 0.2 0.19 11.5 0.1 2.1 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EDK37446.1 - 0.0017 18.3 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.6 EDK37446.1 - 0.013 15.3 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_4 PF13462.6 EDK37446.1 - 0.02 15.1 0.6 1.5 9.0 0.1 2.1 1 1 1 2 2 2 0 Thioredoxin Redoxin PF08534.10 EDK37446.1 - 0.032 14.0 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Redoxin Homeobox_KN PF05920.11 EDK37448.2 - 1.1e-10 41.2 3.3 3.7e-10 39.5 3.3 2.0 1 1 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EDK37448.2 - 0.0088 15.9 3.0 0.014 15.2 3.0 1.3 1 0 0 1 1 1 1 Homeodomain Exo70 PF03081.15 EDK37449.2 - 5.8e-71 239.5 9.9 5.8e-71 239.5 9.9 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.15 EDK37449.2 - 0.021 14.7 0.4 0.021 14.7 0.4 3.1 3 1 0 3 3 3 0 Sec34-like family Alkyl_sulf_dimr PF14863.6 EDK37449.2 - 0.03 14.8 0.0 0.074 13.5 0.0 1.6 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation Sec20 PF03908.13 EDK37449.2 - 1.7 8.6 5.7 11 6.0 0.1 3.8 2 1 0 3 3 3 0 Sec20 tRNA_lig_kinase PF08303.11 EDK37450.2 - 6.8e-65 218.2 0.1 8.1e-64 214.7 0.1 2.4 3 0 0 3 3 3 1 tRNA ligase kinase domain RNA_lig_T4_1 PF09511.10 EDK37450.2 - 2e-41 142.2 0.3 5.4e-41 140.9 0.2 1.8 2 0 0 2 2 2 1 RNA ligase tRNA_lig_CPD PF08302.11 EDK37450.2 - 2.5e-29 102.5 0.0 3.9e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain ABC_tran PF00005.27 EDK37450.2 - 0.0027 18.2 0.1 0.026 15.0 0.1 2.4 2 1 0 2 2 2 1 ABC transporter RNA_ligase PF09414.10 EDK37450.2 - 0.06 13.7 0.1 0.84 9.9 0.0 2.4 2 0 0 2 2 2 0 RNA ligase AcMNPV_Ac109 PF05054.12 EDK37450.2 - 0.11 11.6 0.1 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 Autographa californica nuclear polyhedrosis virus (AcMNPV) protein HhH-GPD PF00730.25 EDK37451.2 - 7.6e-12 45.6 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NYD-SP28_assoc PF14775.6 EDK37451.2 - 0.099 12.8 1.3 0.27 11.4 1.3 1.7 1 0 0 1 1 1 0 Sperm tail C-terminal domain DUF4634 PF15465.6 EDK37451.2 - 0.11 12.8 0.5 0.23 11.8 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) TBD PF12845.7 EDK37452.2 - 0.019 14.9 0.2 0.84 9.6 0.1 2.4 2 0 0 2 2 2 0 TBD domain Transthyretin PF00576.21 EDK37454.2 - 6.5e-25 88.0 0.0 8e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Stn1 PF10451.9 EDK37455.2 - 1.3e-13 50.6 0.5 1.8e-13 50.0 0.5 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Methyltransf_8 PF05148.15 EDK37456.2 - 1.9e-62 211.0 1.2 7.7e-61 205.7 0.2 2.8 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EDK37456.2 - 2.3e-07 31.4 0.3 1.3e-06 29.0 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK37456.2 - 4.1e-05 24.2 0.0 0.00012 22.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK37456.2 - 0.00039 20.2 0.1 0.0011 18.8 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK37456.2 - 0.1 12.1 0.0 14 5.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain DUF3405 PF11885.8 EDK37456.2 - 0.86 8.1 7.0 1.3 7.5 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Methyltransf_32 PF13679.6 EDK37456.2 - 1.3 8.9 0.0 1.3 8.9 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Zip PF02535.22 EDK37456.2 - 2.6 7.2 3.6 5.6 6.1 3.4 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 EDK37456.2 - 6.6 5.4 6.2 9.1 4.9 6.2 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 EDK37456.2 - 9.1 4.3 7.2 13 3.8 7.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WD40 PF00400.32 EDK37457.2 - 7.1e-05 23.5 7.6 0.087 13.7 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37457.2 - 0.00012 22.3 0.4 0.0017 18.6 0.1 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDK37457.2 - 0.045 13.1 0.0 0.18 11.1 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain Ets PF00178.22 EDK37457.2 - 0.12 12.8 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Ets-domain HECT PF00632.25 EDK37458.2 - 4.7e-95 318.6 0.0 6.3e-95 318.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EDK37458.2 - 5.4e-33 112.8 23.4 4.4e-12 45.9 2.1 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EDK37458.2 - 1.6e-21 76.5 0.5 4.2e-21 75.2 0.5 1.7 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.25 EDK37460.2 - 7.6e-25 87.8 0.0 9.8e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37460.2 - 1.6e-11 44.0 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK37460.2 - 3.1e-10 39.4 0.0 4.4e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDK37460.2 - 0.029 14.3 0.0 0.49 10.3 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family MRG PF05712.13 EDK37461.2 - 1.8e-40 138.4 0.2 3.2e-40 137.6 0.2 1.4 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EDK37461.2 - 1.3e-12 47.3 0.9 2.6e-12 46.4 0.9 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Uds1 PF15456.6 EDK37461.2 - 0.055 13.6 1.4 0.094 12.9 1.4 1.4 1 0 0 1 1 1 0 Up-regulated During Septation RGI1 PF10843.8 EDK37462.1 - 5.1e-111 368.9 4.1 5.8e-111 368.7 4.1 1.0 1 0 0 1 1 1 1 Respiratory growth induced protein 1 CaMKII_AD PF08332.10 EDK37462.1 - 0.095 12.8 0.2 0.15 12.2 0.2 1.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain Tim17 PF02466.19 EDK37463.2 - 9.4e-38 129.0 6.8 1.4e-37 128.5 6.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DLH PF01738.18 EDK37463.2 - 0.049 13.2 0.7 0.071 12.7 0.2 1.5 1 1 1 2 2 2 0 Dienelactone hydrolase family CbtA PF09490.10 EDK37463.2 - 0.066 13.0 1.6 1.9 8.2 0.1 2.1 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) IDH PF03971.14 EDK37464.2 - 0.017 13.6 0.1 0.021 13.3 0.1 1.1 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase Chitin_synth_1 PF01644.17 EDK37465.2 - 2.3e-70 235.8 0.0 3.7e-70 235.1 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 EDK37465.2 - 1.9e-24 86.2 3.1 1.3e-16 60.4 0.0 3.3 3 1 0 3 3 3 2 Chitin synthase Chitin_synth_1N PF08407.11 EDK37465.2 - 2.6e-23 81.7 0.0 6.7e-23 80.4 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Glycos_transf_2 PF00535.26 EDK37465.2 - 0.0082 16.0 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 DUF2189 PF09955.9 EDK37465.2 - 0.39 11.0 12.4 0.49 10.6 0.0 3.2 2 1 1 3 3 3 0 Predicted integral membrane protein (DUF2189) A_deaminase PF00962.22 EDK37466.1 - 6.2e-83 278.8 0.0 7.1e-83 278.7 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Atg8 PF02991.16 EDK37467.1 - 1.2e-45 153.9 0.0 1.5e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EDK37467.1 - 2.2e-05 24.8 0.0 3.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Holin_BhlA PF10960.8 EDK37467.1 - 0.12 12.3 0.2 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 BhlA holin family Tantalus PF15386.6 EDK37467.1 - 0.12 12.4 0.1 0.37 10.9 0.0 1.9 2 0 0 2 2 2 0 Drosophila Tantalus-like GatB_N PF02934.15 EDK37468.2 - 2.4e-92 309.2 0.0 3.2e-92 308.8 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EDK37468.2 - 1.9e-25 89.5 0.1 3.8e-25 88.5 0.1 1.5 1 0 0 1 1 1 1 GatB domain STE3 PF02076.15 EDK37469.2 - 4.2e-71 239.5 20.7 4.9e-71 239.3 20.7 1.0 1 0 0 1 1 1 1 Pheromone A receptor Mito_carr PF00153.27 EDK37469.2 - 0.051 13.5 0.4 0.13 12.2 0.4 1.6 1 0 0 1 1 1 0 Mitochondrial carrier protein ETRAMP PF09716.10 EDK37469.2 - 1.2 9.2 4.3 19 5.4 0.0 3.5 4 0 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) Stevor PF17410.2 EDK37469.2 - 9.1 5.7 9.0 2.3 7.7 3.0 2.2 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame HEAT_EZ PF13513.6 EDK37470.2 - 2.3e-14 53.5 3.7 0.00073 20.0 0.0 9.0 9 0 0 9 9 9 2 HEAT-like repeat HEAT PF02985.22 EDK37470.2 - 1.9e-12 46.3 1.3 0.012 15.8 0.0 10.1 13 0 0 13 13 10 2 HEAT repeat RIX1 PF08167.12 EDK37470.2 - 1.3e-10 41.4 0.4 0.0095 15.7 0.0 5.8 5 1 1 6 6 6 3 rRNA processing/ribosome biogenesis IBN_N PF03810.19 EDK37470.2 - 1.6e-09 37.5 2.4 2.4e-08 33.8 0.7 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDK37470.2 - 3e-08 33.9 6.5 0.061 13.7 0.0 7.1 5 2 2 7 7 7 3 HEAT repeats ParcG PF10274.9 EDK37470.2 - 4.7e-07 30.1 0.3 0.1 12.7 0.1 4.2 3 1 1 4 4 4 2 Parkin co-regulated protein Vac14_Fab1_bd PF12755.7 EDK37470.2 - 6.3e-07 29.9 2.1 2.5 8.8 0.0 6.8 7 1 1 8 8 7 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EDK37470.2 - 5.5e-05 22.5 11.8 0.1 11.7 0.1 5.0 3 2 2 5 5 5 3 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 EDK37470.2 - 7.5e-05 22.7 4.0 0.075 12.9 0.0 5.3 3 2 1 5 5 5 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 EDK37470.2 - 0.00024 21.2 10.3 0.19 11.8 0.2 5.8 6 2 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDK37470.2 - 0.00067 19.3 3.7 0.22 11.0 0.0 4.4 5 1 0 5 5 5 1 CLASP N terminal FANCI_S3 PF14677.6 EDK37470.2 - 0.012 15.4 0.2 0.075 12.7 0.1 2.5 2 0 0 2 2 2 0 FANCI solenoid 3 DUF1981 PF09324.10 EDK37470.2 - 0.041 13.7 0.1 15 5.5 0.0 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) DEAD PF00270.29 EDK37471.2 - 1.7e-43 148.4 0.8 3.1e-43 147.6 0.8 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37471.2 - 1.1e-31 109.5 0.1 1.2e-30 106.1 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EDK37471.2 - 2.4e-05 24.1 0.1 5.8e-05 22.9 0.1 1.5 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EDK37471.2 - 0.00023 21.2 0.0 0.00051 20.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDK37471.2 - 0.0024 18.2 0.2 0.0045 17.3 0.2 1.5 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EDK37471.2 - 0.0028 17.5 0.0 0.0052 16.7 0.0 1.5 1 0 0 1 1 1 1 Helicase DUF3419 PF11899.8 EDK37471.2 - 0.009 15.2 0.0 0.12 11.5 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3419) PRK PF00485.18 EDK37472.1 - 1.1e-15 58.0 0.7 3.9e-14 52.9 0.7 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 EDK37472.1 - 0.0027 17.6 0.1 0.0056 16.5 0.1 1.6 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EDK37472.1 - 0.0056 17.2 0.2 0.047 14.2 0.1 2.3 1 1 1 2 2 2 1 AAA domain CoaE PF01121.20 EDK37472.1 - 0.023 14.4 0.1 0.25 11.0 0.1 2.1 1 1 1 2 2 2 0 Dephospho-CoA kinase Nucleoporin_N PF08801.11 EDK37474.2 - 5.8e-140 466.9 10.9 8.3e-140 466.4 10.9 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDK37474.2 - 7.1e-108 361.9 2.2 6.4e-107 358.7 2.2 2.0 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Peptidase_M28 PF04389.17 EDK37475.2 - 1.5e-26 93.3 0.0 2.5e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDK37475.2 - 0.00035 20.3 0.0 0.00055 19.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 SSB PF00436.25 EDK37476.2 - 1.9e-18 66.4 0.0 2.4e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family SecY PF00344.20 EDK37478.1 - 2.3e-46 158.5 15.2 2.7e-46 158.2 15.2 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDK37478.1 - 0.00039 20.2 0.5 0.0017 18.1 0.0 2.3 2 0 0 2 2 2 1 Plug domain of Sec61p DUF2973 PF11189.8 EDK37478.1 - 0.63 10.2 2.2 26 5.0 0.1 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2973) Ras PF00071.22 EDK37479.1 - 1.1e-47 161.7 0.1 1.3e-47 161.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37479.1 - 7.3e-37 126.2 0.0 1.4e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37479.1 - 3.8e-18 65.6 0.0 4.9e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDK37479.1 - 1.5e-06 28.3 0.0 2.3e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37479.1 - 4.7e-06 26.6 0.5 0.012 15.5 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EDK37479.1 - 1.6e-05 24.4 0.1 1.9e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDK37479.1 - 2.1e-05 24.1 0.1 0.00017 21.2 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDK37479.1 - 0.00058 19.3 0.0 0.0011 18.4 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EDK37479.1 - 0.0015 18.3 0.0 0.73 9.6 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EDK37479.1 - 0.0037 16.8 0.4 0.18 11.3 0.4 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_24 PF13479.6 EDK37479.1 - 0.0089 15.8 0.6 0.05 13.3 0.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDK37479.1 - 0.014 15.8 0.0 0.045 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 EDK37479.1 - 0.022 13.6 0.2 4.2 6.1 0.1 2.1 1 1 0 2 2 2 0 Dynein light intermediate chain (DLIC) TniB PF05621.11 EDK37479.1 - 0.034 13.6 0.0 0.09 12.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein PAP_assoc PF03828.19 EDK37480.2 - 1e-15 57.6 0.1 2.9e-15 56.2 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EDK37480.2 - 4.7e-15 55.7 2.5 2.9e-13 49.9 0.1 2.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDK37480.2 - 0.00056 20.0 0.1 0.00056 20.0 0.1 2.5 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase TRAUB PF08164.12 EDK37480.2 - 1.1 9.8 5.5 0.19 12.2 0.6 2.3 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal SMAP PF15477.6 EDK37480.2 - 1.5 9.8 3.7 0.88 10.6 0.6 2.2 2 0 0 2 2 2 0 Small acidic protein family Pkinase PF00069.25 EDK37481.2 - 1.2e-26 93.7 0.0 9.9e-25 87.4 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37481.2 - 5.3e-15 55.4 0.0 1e-12 47.9 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK37481.2 - 1.2e-05 24.2 0.0 1.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDK37481.2 - 0.067 12.5 0.6 0.22 10.9 0.1 1.9 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rif1_N PF12231.8 EDK37483.2 - 9.2e-08 31.5 0.1 1.9e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Rif1_N PF12231.8 EDK37484.1 - 7.5e-06 25.2 0.6 1e-05 24.7 0.2 1.4 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal RF-1 PF00472.20 EDK37486.1 - 1.8e-19 69.7 0.3 2.5e-19 69.3 0.3 1.2 1 0 0 1 1 1 1 RF-1 domain RRP14 PF15459.6 EDK37486.1 - 0.15 12.7 8.2 0.31 11.7 8.2 1.5 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 Spt20 PF12090.8 EDK37487.2 - 3.3e-60 203.6 2.6 3.3e-60 203.6 2.6 6.8 2 2 2 4 4 4 1 Spt20 family FHA PF00498.26 EDK37488.2 - 1.2e-13 51.1 0.0 3.2e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain Transposase_24 PF03004.14 EDK37488.2 - 0.96 9.6 7.8 0.11 12.6 2.9 2.0 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) CDC45 PF02724.14 EDK37488.2 - 8 4.6 11.5 4.3 5.5 1.2 2.0 2 0 0 2 2 2 0 CDC45-like protein PhyH PF05721.13 EDK37489.2 - 1.6e-45 156.0 0.0 1.9e-45 155.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EDK37489.2 - 0.048 14.1 0.0 0.095 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Transp_cyt_pur PF02133.15 EDK37490.2 - 1.3e-16 60.5 42.5 4.3e-16 58.7 42.4 1.7 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TENA_THI-4 PF03070.16 EDK37491.2 - 4.7e-12 46.2 0.2 7.7e-12 45.5 0.2 1.3 1 1 0 1 1 1 1 TENA/THI-4/PQQC family CPG4 PF15481.6 EDK37491.2 - 0.14 12.8 0.2 0.63 10.7 0.1 2.0 2 0 0 2 2 2 0 Chondroitin proteoglycan 4 SCO1-SenC PF02630.14 EDK37492.2 - 2.1e-44 150.7 0.0 3.1e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EDK37492.2 - 0.0099 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family SET PF00856.28 EDK37493.2 - 1.3e-07 32.2 0.2 4.5e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 SET domain Pho88 PF10032.9 EDK37494.1 - 2e-79 265.1 0.7 2.2e-79 265.0 0.7 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) PAPS_reduct PF01507.19 EDK37494.1 - 0.027 14.5 0.1 0.12 12.4 0.0 1.8 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family SNase PF00565.17 EDK37495.2 - 1e-34 119.2 0.0 2.9e-10 40.6 0.0 5.5 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EDK37495.2 - 1.7e-13 50.7 0.0 3.6e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Tudor domain LBR_tudor PF09465.10 EDK37495.2 - 0.14 12.0 1.1 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain UQ_con PF00179.26 EDK37496.1 - 1e-49 167.8 0.0 1.2e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Amino_oxidase PF01593.24 EDK37497.2 - 7.6e-59 200.2 0.0 1e-58 199.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDK37497.2 - 7.3e-13 48.6 0.0 1.5e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDK37497.2 - 1.2e-06 28.6 0.0 0.0013 18.8 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EDK37497.2 - 7.7e-05 22.4 0.0 0.0024 17.5 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase MCRA PF06100.11 EDK37497.2 - 0.007 15.2 0.0 0.01 14.7 0.0 1.2 1 0 0 1 1 1 1 MCRA family Thi4 PF01946.17 EDK37497.2 - 0.018 14.3 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EDK37497.2 - 0.021 14.0 0.3 0.24 10.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDK37497.2 - 0.032 12.9 0.1 0.81 8.3 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EDK37497.2 - 0.035 14.7 0.4 0.61 10.7 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK37497.2 - 0.054 12.7 0.3 4 6.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt_4 PF04669.13 EDK37498.1 - 6.6e-21 74.7 0.7 3.3e-19 69.2 0.7 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Striatin PF08232.12 EDK37499.2 - 3.1e-16 60.4 0.2 3.1e-16 60.4 0.2 2.8 2 1 1 3 3 3 1 Striatin family DUF16 PF01519.16 EDK37499.2 - 0.044 14.3 0.1 0.14 12.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 WD40_alt PF14077.6 EDK37499.2 - 0.055 13.3 0.5 5.4 7.0 0.1 2.9 1 1 1 2 2 2 0 Alternative WD40 repeat motif ABC_tran PF00005.27 EDK37500.2 - 4.2e-48 163.3 2.3 4.9e-27 95.1 0.0 4.7 4 3 1 5 5 2 2 ABC transporter AAA_21 PF13304.6 EDK37500.2 - 3.4e-15 56.6 0.2 0.0014 18.5 0.3 4.9 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system Chromo PF00385.24 EDK37500.2 - 1e-10 41.3 1.0 2.9e-10 39.9 1.0 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SMC_N PF02463.19 EDK37500.2 - 1.3e-09 37.8 0.0 0.022 14.2 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDK37500.2 - 3.2e-09 37.6 6.7 0.0012 19.4 0.1 3.6 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EDK37500.2 - 2.7e-07 30.2 0.5 0.017 14.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDK37500.2 - 7.1e-07 29.3 0.0 0.017 15.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37500.2 - 2.2e-06 27.7 0.1 0.029 14.3 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EDK37500.2 - 2.5e-05 24.6 0.0 0.17 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDK37500.2 - 2.7e-05 24.4 0.0 0.12 12.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EDK37500.2 - 5.6e-05 23.0 1.8 0.92 9.1 0.0 3.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 EDK37500.2 - 0.00016 22.3 0.0 0.5 10.9 0.0 3.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK37500.2 - 0.0015 18.9 0.0 2.7 8.4 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_13 PF13166.6 EDK37500.2 - 0.0021 16.8 1.0 0.92 8.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain MeaB PF03308.16 EDK37500.2 - 0.0024 16.9 0.1 0.61 9.0 0.0 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 EDK37500.2 - 0.003 17.2 0.0 1.9 8.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDK37500.2 - 0.0034 17.5 0.0 3 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK37500.2 - 0.0052 17.2 0.1 0.94 9.8 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EDK37500.2 - 0.0085 16.5 0.0 9.5 6.7 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EDK37500.2 - 0.0095 16.1 5.9 0.1 12.7 0.1 3.6 4 0 0 4 4 3 1 Helicase HerA, central domain NACHT PF05729.12 EDK37500.2 - 0.01 15.8 0.4 3.9 7.4 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EDK37500.2 - 0.015 15.0 2.5 7.4 6.2 0.1 3.2 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDK37500.2 - 0.015 14.6 0.3 11 5.3 0.0 3.3 3 0 0 3 3 3 0 Zeta toxin Roc PF08477.13 EDK37500.2 - 0.015 15.5 0.0 2.9 8.1 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EDK37500.2 - 0.016 15.2 0.0 1.6 8.7 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EDK37500.2 - 0.021 14.5 0.2 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EDK37500.2 - 0.029 14.4 3.4 0.46 10.5 0.0 3.5 4 0 0 4 4 3 0 Dynamin family DUF815 PF05673.13 EDK37500.2 - 0.047 12.8 0.4 4.8 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 EDK37500.2 - 0.074 12.2 0.1 3.7 6.7 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 EDK37500.2 - 0.084 12.8 0.1 3.4 7.6 0.0 2.8 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_14 PF13173.6 EDK37500.2 - 0.088 12.8 0.0 9.3 6.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDK37500.2 - 0.097 12.3 0.2 28 4.3 0.1 3.3 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF3584 PF12128.8 EDK37500.2 - 0.62 7.5 5.3 3.7 4.9 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) LAT PF15234.6 EDK37500.2 - 1.3 8.7 5.7 0.087 12.5 0.3 1.7 2 0 0 2 2 1 0 Linker for activation of T-cells Proteasome PF00227.26 EDK37501.2 - 1.3e-43 148.7 0.0 1.5e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Utp14 PF04615.13 EDK37502.2 - 3.2e-194 647.7 76.2 3.2e-194 647.7 76.2 2.1 1 1 1 2 2 2 1 Utp14 protein PP2C_C PF07830.13 EDK37502.2 - 5.6 7.5 6.1 10 6.6 0.0 3.7 3 0 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain ALO PF04030.14 EDK37503.1 - 1.2e-99 333.3 0.4 2.2e-99 332.5 0.1 1.5 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EDK37503.1 - 1.9e-22 79.5 0.0 3.4e-22 78.7 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain SIS_2 PF13580.6 EDK37503.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 SIS domain PEX11 PF05648.14 EDK37504.2 - 0.0002 20.9 0.2 0.00029 20.4 0.2 1.3 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) HlyD_D4 PF16572.5 EDK37504.2 - 0.17 11.7 0.3 16 5.4 0.0 2.6 3 0 0 3 3 3 0 Long alpha hairpin domain of cation efflux system protein, CusB Dsl1_C PF11989.8 EDK37505.2 - 1e-11 44.9 7.8 1e-11 44.9 7.8 2.3 2 1 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal HMA PF00403.26 EDK37506.1 - 1.6e-13 50.8 0.3 1.9e-13 50.7 0.3 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF211 PF02680.14 EDK37506.1 - 0.014 15.6 0.4 0.022 14.9 0.4 1.3 1 1 0 1 1 1 0 Uncharacterized ArCR, COG1888 ABC_membrane PF00664.23 EDK37507.2 - 2e-54 185.1 36.2 3.4e-33 115.5 12.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK37507.2 - 6e-50 169.3 0.4 1.6e-29 103.2 0.0 3.3 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK37507.2 - 5.1e-09 35.9 9.2 0.00026 20.5 0.1 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK37507.2 - 1e-08 35.4 2.9 0.035 13.9 0.0 3.8 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDK37507.2 - 1.3e-08 34.5 0.3 0.00023 20.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EDK37507.2 - 1.3e-07 31.7 0.0 0.0047 16.7 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDK37507.2 - 9.1e-07 28.9 0.3 0.047 13.6 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_23 PF13476.6 EDK37507.2 - 2.4e-05 24.9 7.9 0.037 14.5 0.3 3.2 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EDK37507.2 - 2.9e-05 24.1 1.0 0.015 15.4 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EDK37507.2 - 0.0004 20.9 0.3 1.2 9.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.23 EDK37507.2 - 0.00052 20.1 1.1 0.55 10.3 0.0 2.6 2 0 0 2 2 2 2 Dynamin family AAA_16 PF13191.6 EDK37507.2 - 0.001 19.5 2.5 0.82 10.0 0.0 3.0 3 1 0 3 3 2 2 AAA ATPase domain AAA_30 PF13604.6 EDK37507.2 - 0.0032 17.2 0.3 1 9.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EDK37507.2 - 0.0038 16.3 0.0 0.22 10.5 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 EDK37507.2 - 0.0063 16.8 2.6 4.1 7.7 0.3 3.3 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDK37507.2 - 0.02 14.6 0.0 9.7 5.9 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 EDK37507.2 - 0.022 14.1 0.2 7.3 5.9 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 EDK37507.2 - 0.025 14.4 1.2 1 9.1 0.3 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 EDK37507.2 - 0.057 12.7 0.1 3.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_27 PF13514.6 EDK37507.2 - 0.058 13.0 0.2 3.1 7.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EDK37507.2 - 0.06 12.3 0.1 1.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EDK37507.2 - 0.082 12.4 0.3 10 5.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 EDK37507.2 - 0.095 12.3 0.2 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.25 EDK37507.2 - 0.11 12.1 0.0 3.4 7.3 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.18 EDK37507.2 - 0.14 12.1 1.6 8.7 6.2 0.0 3.2 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea WD40 PF00400.32 EDK37510.2 - 0.00016 22.4 4.6 0.094 13.6 0.4 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat T4_baseplate PF12322.8 EDK37510.2 - 0.053 13.0 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 T4 bacteriophage base plate protein Yae1_N PF09811.9 EDK37511.1 - 2.2e-12 46.5 5.2 4e-12 45.6 5.2 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Tweety PF04906.13 EDK37511.1 - 0.1 11.2 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 Tweety AATase PF07247.12 EDK37512.2 - 1.8e-47 162.0 0.0 3e-47 161.3 0.0 1.2 1 1 0 1 1 1 1 Alcohol acetyltransferase GYF PF02213.16 EDK37513.2 - 4.5e-11 42.2 0.8 9.7e-11 41.2 0.8 1.6 1 0 0 1 1 1 1 GYF domain DUF1107 PF06526.12 EDK37513.2 - 0.008 16.1 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1107) GYF_2 PF14237.6 EDK37513.2 - 0.086 12.7 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 GYF domain 2 CDT1_C PF16679.5 EDK37513.2 - 0.095 13.1 0.8 0.19 12.2 0.8 1.5 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain ORC5_C PF14630.6 EDK37514.2 - 1e-70 238.5 0.3 1.4e-70 238.1 0.3 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EDK37514.2 - 5.2e-11 43.2 0.0 1.1e-10 42.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDK37514.2 - 0.0011 19.4 0.0 0.026 14.9 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDK37514.2 - 0.0055 16.6 0.1 0.014 15.3 0.1 1.7 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EDK37514.2 - 0.0055 17.0 0.3 0.019 15.2 0.3 2.0 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDK37514.2 - 0.034 14.1 0.2 0.11 12.4 0.0 2.1 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDK37514.2 - 0.082 13.3 0.1 21 5.6 0.0 3.5 3 0 0 3 3 3 0 RNA helicase AAA_24 PF13479.6 EDK37514.2 - 0.082 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2614 PF11023.8 EDK37514.2 - 0.11 12.6 0.1 0.53 10.4 0.1 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain AAA_14 PF13173.6 EDK37514.2 - 0.12 12.4 2.1 0.64 10.1 0.5 2.7 2 1 0 2 2 2 0 AAA domain DUF1744 PF08490.12 EDK37515.2 - 2e-135 451.5 2.4 2.8e-135 450.9 2.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EDK37515.2 - 6.6e-78 262.2 3.5 2.5e-77 260.3 3.4 2.2 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EDK37515.2 - 1.4e-17 63.6 0.0 6.1e-16 58.2 0.0 2.5 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EDK37515.2 - 1e-07 31.9 0.2 5.6e-07 29.5 0.2 2.3 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EDK37515.2 - 2.5e-05 24.3 0.1 0.00011 22.3 0.1 2.1 1 0 0 1 1 1 1 RNase_H superfamily Peptidase_M76 PF09768.9 EDK37515.2 - 0.016 15.0 3.9 0.086 12.6 4.1 2.0 2 0 0 2 2 2 0 Peptidase M76 family YIF1 PF03878.15 EDK37516.2 - 6.9e-86 287.6 11.8 9.5e-86 287.2 11.8 1.2 1 0 0 1 1 1 1 YIF1 Ninjurin PF04923.12 EDK37516.2 - 9.2 6.3 8.9 27 4.8 5.7 2.9 3 1 0 3 3 3 0 Ninjurin Glyco_transf_20 PF00982.21 EDK37517.2 - 2.6e-200 666.1 0.0 3e-200 665.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 EDK37517.2 - 6.1e-05 22.6 0.2 0.0082 15.7 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EDK37517.2 - 0.05 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Starch synthase catalytic domain Nuf2 PF03800.14 EDK37518.2 - 0.2 11.8 1.5 1.6 8.9 0.1 2.5 1 1 1 2 2 2 0 Nuf2 family PP2C PF00481.21 EDK37519.2 - 1.5e-56 191.9 0.0 2.7e-54 184.5 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_hydro_130 PF04041.13 EDK37520.2 - 1.3e-39 136.0 0.1 1.7e-39 135.6 0.1 1.1 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase Glyco_hydro_32N PF00251.20 EDK37520.2 - 3.1e-10 40.1 1.1 3.2e-09 36.8 0.2 2.8 2 1 2 4 4 4 3 Glycosyl hydrolases family 32 N-terminal domain HtrL_YibB PF09612.10 EDK37520.2 - 0.069 12.7 0.2 0.12 11.9 0.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) G-alpha PF00503.20 EDK37521.2 - 0.019 14.1 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Ras PF00071.22 EDK37521.2 - 0.031 13.9 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Ras family Ploopntkinase3 PF18751.1 EDK37521.2 - 0.05 13.5 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EDK37521.2 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDK37521.2 - 0.13 12.3 0.0 0.37 10.9 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.6 EDK37521.2 - 0.15 12.4 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain FerA PF08165.11 EDK37522.2 - 0.02 14.8 0.0 0.17 11.8 0.0 2.6 2 0 0 2 2 2 0 FerA (NUC095) domain DASH_Duo1 PF08651.10 EDK37522.2 - 0.04 13.7 0.4 0.04 13.7 0.4 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 Filament PF00038.21 EDK37522.2 - 0.042 13.4 1.9 0.1 12.1 1.9 1.6 1 0 0 1 1 1 0 Intermediate filament protein ATP-synt_ab PF00006.25 EDK37523.2 - 1.1e-65 221.3 0.0 1.6e-65 220.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDK37523.2 - 8.4e-13 48.6 0.9 1.7e-12 47.7 0.9 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Aconitase PF00330.20 EDK37524.2 - 2.7e-149 498.1 0.0 3.5e-149 497.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDK37524.2 - 4.6e-42 143.4 0.0 8.1e-42 142.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain RasGEF PF00617.19 EDK37525.2 - 9.7e-45 152.9 3.1 3.8e-44 151.0 3.1 2.0 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDK37525.2 - 8.4e-13 48.5 1.3 4.3e-12 46.2 1.3 2.4 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDK37525.2 - 0.00042 19.9 0.0 0.001 18.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK37525.2 - 0.03 14.2 0.0 0.26 11.2 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain AAA_12 PF13087.6 EDK37526.2 - 1.8e-58 197.5 0.1 3.5e-58 196.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDK37526.2 - 5.8e-38 131.2 1.6 2.4e-18 66.9 0.3 2.3 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 EDK37526.2 - 7.8e-12 45.8 0.1 2e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDK37526.2 - 8e-11 42.0 0.0 5.1e-10 39.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDK37526.2 - 7.5e-06 25.8 0.0 0.13 12.0 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EDK37526.2 - 2.3e-05 24.4 0.1 0.00012 22.1 0.1 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 EDK37526.2 - 0.00022 21.2 0.2 0.00059 19.8 0.2 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 EDK37526.2 - 0.00041 20.8 0.1 0.0014 19.0 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 EDK37526.2 - 0.00085 18.9 0.1 0.0016 18.0 0.1 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EDK37526.2 - 0.0015 18.0 0.2 0.02 14.3 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 EDK37526.2 - 0.0018 17.6 0.8 0.4 9.9 0.3 3.2 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDK37526.2 - 0.0025 18.1 0.1 0.0072 16.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EDK37526.2 - 0.01 15.7 0.0 0.034 14.0 0.0 1.9 2 0 0 2 2 2 0 Helicase AAA_7 PF12775.7 EDK37526.2 - 0.01 15.4 0.0 0.037 13.5 0.0 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EDK37526.2 - 0.026 15.0 0.4 0.27 11.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDK37526.2 - 0.049 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EDK37526.2 - 0.05 13.2 0.1 0.14 11.8 0.1 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDK37526.2 - 0.058 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase DEAD PF00270.29 EDK37526.2 - 0.073 12.8 2.6 1.1 9.0 2.6 2.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase Thioredoxin_4 PF13462.6 EDK37528.2 - 6.2e-07 29.7 0.2 3.1e-06 27.5 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EDK37528.2 - 0.13 12.0 0.2 0.41 10.4 0.1 1.8 2 0 0 2 2 2 0 DSBA-like thioredoxin domain SH3_1 PF00018.28 EDK37530.2 - 2.6e-22 78.2 0.1 1.8e-11 43.5 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EDK37530.2 - 1.8e-15 56.5 0.1 2.6e-09 36.8 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EDK37530.2 - 2.4e-11 43.6 0.1 5e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EDK37530.2 - 1.2e-09 37.7 0.0 1.4e-06 27.9 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EDK37530.2 - 0.11 12.4 0.5 0.25 11.3 0.1 1.8 2 0 0 2 2 2 0 PB1 domain Zn_clus PF00172.18 EDK37531.2 - 1.5e-07 31.4 12.1 3.1e-07 30.4 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Swm2 PF17083.5 EDK37531.2 - 0.0089 16.0 0.0 0.028 14.4 0.0 1.8 1 0 0 1 1 1 1 Nucleolar protein Swm2 Enolase_N PF03952.16 EDK37532.1 - 5e-51 172.3 0.0 5.9e-51 172.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, N-terminal domain Enolase_C PF00113.22 EDK37532.1 - 0.00015 21.1 0.0 0.00024 20.4 0.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain ALS_ss_C PF10369.9 EDK37533.2 - 6.3e-17 61.5 0.1 3.7e-16 59.1 0.0 2.3 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 EDK37533.2 - 3e-13 49.3 0.1 6.2e-13 48.3 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EDK37533.2 - 1.1e-05 25.2 0.0 1.9e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EDK37533.2 - 0.15 12.1 0.1 31 4.6 0.0 2.8 3 0 0 3 3 3 0 ACT domain OPT PF03169.15 EDK37534.2 - 4.6e-157 524.3 36.6 5.3e-157 524.1 36.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Eisosome1 PF12757.7 EDK37536.2 - 6.1e-22 78.2 7.1 6.1e-22 78.2 7.1 2.5 3 0 0 3 3 3 1 Eisosome protein 1 zf-C2H2 PF00096.26 EDK37537.2 - 3.6e-13 49.2 14.5 6.2e-07 29.5 2.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK37537.2 - 3.6e-09 36.7 13.7 0.00015 22.3 2.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK37537.2 - 4.8e-08 33.1 8.5 0.001 19.3 0.2 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EDK37537.2 - 3.4e-07 30.4 18.4 1e-05 25.7 5.3 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-BED PF02892.15 EDK37537.2 - 1.7e-05 24.7 3.8 0.045 13.8 1.4 2.5 2 0 0 2 2 2 2 BED zinc finger zf-met PF12874.7 EDK37537.2 - 0.00031 21.0 5.7 0.29 11.6 2.3 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDK37537.2 - 0.0034 17.3 4.0 0.0034 17.3 4.0 2.7 2 1 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 EDK37537.2 - 0.0039 17.5 4.8 0.0077 16.5 4.8 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EDK37537.2 - 0.0091 16.3 5.0 0.12 12.8 0.6 2.3 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 EDK37537.2 - 0.018 15.5 8.7 0.52 10.8 2.2 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 EDK37537.2 - 0.029 14.5 2.4 2.2 8.5 0.3 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zf-H2C2_5 PF13909.6 EDK37537.2 - 0.13 12.1 13.3 1.9 8.3 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain PyrI_C PF02748.15 EDK37537.2 - 0.2 11.6 1.5 0.4 10.6 1.5 1.5 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf_UBZ PF18439.1 EDK37537.2 - 0.52 9.9 3.2 4 7.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF629 PF04780.12 EDK37537.2 - 0.59 8.6 5.5 2.6 6.5 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) FOXP-CC PF16159.5 EDK37537.2 - 0.61 10.8 2.9 3.7 8.3 0.3 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-LYAR PF08790.11 EDK37537.2 - 0.94 9.4 5.0 0.58 10.1 0.1 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 EDK37537.2 - 4.3 7.1 7.5 6 6.6 0.2 2.7 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Actin_micro PF17003.5 EDK37537.2 - 5 6.2 4.6 7 5.7 2.6 1.9 1 1 1 2 2 2 0 Putative actin-like family DUF3322 PF11795.8 EDK37538.2 - 0.022 14.8 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Acetyltransf_1 PF00583.25 EDK37539.1 - 4.3e-14 52.8 0.0 4.9e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK37539.1 - 2.4e-07 31.1 0.0 3.6e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK37539.1 - 5.5e-06 26.3 0.0 7.1e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDK37539.1 - 0.00018 22.2 0.0 0.00025 21.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDK37539.1 - 0.0022 18.2 0.0 0.0027 17.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK37539.1 - 0.024 14.8 0.0 0.048 13.8 0.0 1.6 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Fungal_trans_2 PF11951.8 EDK37540.2 - 2.1e-84 283.6 7.4 3.2e-84 283.0 7.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37540.2 - 1.9e-06 27.9 10.1 6.5e-06 26.2 10.1 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FmiP_Thoc5 PF09766.9 EDK37540.2 - 0.17 11.1 3.1 0.28 10.4 3.1 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Zn_clus PF00172.18 EDK37541.2 - 9e-09 35.3 10.8 1.5e-08 34.6 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK37541.2 - 6.5e-05 22.1 0.0 0.00013 21.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain ANAPC5 PF12862.7 EDK37541.2 - 0.13 12.4 0.6 0.39 10.8 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Sugar_tr PF00083.24 EDK37542.2 - 2.4e-92 310.2 25.7 2.8e-92 309.9 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37542.2 - 1.1e-16 60.7 31.2 2.2e-16 59.8 26.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK37542.2 - 2.1e-06 26.6 19.5 8.1e-05 21.3 0.6 2.8 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EDK37542.2 - 0.00048 19.1 3.0 0.00048 19.1 3.0 2.3 2 0 0 2 2 2 1 MFS_1 like family Tetraspanin PF00335.20 EDK37542.2 - 0.54 9.9 6.6 1.8 8.2 6.6 2.0 1 0 0 1 1 1 0 Tetraspanin family Sugar_tr PF00083.24 EDK37543.2 - 1.5e-89 300.9 26.6 1.8e-89 300.7 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37543.2 - 6.9e-13 48.2 34.7 8.5e-11 41.4 29.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK37543.2 - 1.1e-05 24.2 23.6 0.0014 17.3 2.9 2.8 2 1 1 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 EDK37544.1 - 2.4e-90 303.6 26.8 2.8e-90 303.4 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37544.1 - 2e-15 56.6 30.8 4.9e-14 52.0 25.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK37544.1 - 1e-08 34.2 23.0 4.4e-07 28.8 1.9 3.2 2 1 1 3 3 3 2 MFS/sugar transport protein Alpha-amylase PF00128.24 EDK37545.2 - 1.5e-116 389.7 2.4 2.5e-116 389.0 2.4 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EDK37545.2 - 0.0011 18.1 0.1 0.0021 17.2 0.1 1.4 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Malt_amylase_C PF16657.5 EDK37545.2 - 0.0019 18.2 0.0 0.0041 17.2 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Glyco_hydro_42C PF08533.10 EDK37545.2 - 0.035 13.8 0.1 0.088 12.5 0.1 1.6 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain FHA PF00498.26 EDK37546.2 - 3.1e-14 53.1 0.0 6.6e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EDK37546.2 - 7.3e-12 44.8 5.7 1.4e-11 44.0 5.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDK37546.2 - 6.9e-07 29.5 9.4 1.4e-06 28.5 9.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDK37546.2 - 0.0011 18.8 9.3 0.002 18.0 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Yop-YscD_cpl PF16697.5 EDK37546.2 - 0.0014 18.9 0.5 0.0041 17.4 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_2 PF13923.6 EDK37546.2 - 0.009 15.8 9.1 0.017 15.0 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDK37546.2 - 0.0099 15.9 4.5 0.019 15.0 4.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EDK37546.2 - 0.017 15.1 6.7 0.03 14.3 6.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 EDK37546.2 - 0.022 15.0 6.2 0.067 13.5 6.2 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain TFIIA PF03153.13 EDK37546.2 - 0.046 13.7 23.9 0.071 13.1 23.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PHD PF00628.29 EDK37546.2 - 0.96 9.4 9.7 0.15 12.0 5.2 2.0 2 0 0 2 2 2 0 PHD-finger Suf PF05843.14 EDK37546.2 - 1.1 9.2 7.1 1.5 8.7 7.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) zf-RING_UBOX PF13445.6 EDK37546.2 - 1.4 9.0 8.8 2.9 8.0 8.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Tim54 PF11711.8 EDK37546.2 - 1.6 7.4 4.7 2.5 6.8 4.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 EDK37546.2 - 1.6 8.7 6.4 3 7.8 6.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 EDK37546.2 - 1.7 5.7 11.0 2.1 5.4 11.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 EDK37546.2 - 2.5 6.9 11.8 3.4 6.4 11.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EDK37546.2 - 2.6 6.7 13.3 4.1 6.1 13.3 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EDK37546.2 - 3.3 6.8 5.1 4.7 6.3 5.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 EDK37546.2 - 8 4.9 11.8 5 5.6 10.0 1.6 2 0 0 2 2 2 0 Macoilin family Band_3_cyto PF07565.13 EDK37546.2 - 8.5 6.1 8.4 12 5.6 8.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2417 PF10329.9 EDK37547.2 - 3.6e-73 245.9 4.7 5.4e-73 245.3 4.7 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 EDK37547.2 - 1.4e-07 31.4 0.0 2.1e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK37547.2 - 3.1e-05 24.7 0.0 5.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EDK37547.2 - 3.9e-05 23.9 0.0 5.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Palm_thioest PF02089.15 EDK37547.2 - 0.04 13.7 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase PX PF00787.24 EDK37548.2 - 4.1e-12 46.1 1.7 6.3e-12 45.5 0.1 2.1 2 1 0 2 2 2 1 PX domain DUF4554 PF15091.6 EDK37548.2 - 0.021 13.7 2.8 0.03 13.2 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) AAA_13 PF13166.6 EDK37548.2 - 0.11 11.2 15.1 0.67 8.5 15.1 2.0 1 1 0 1 1 1 0 AAA domain Syntaxin-6_N PF09177.11 EDK37548.2 - 1.9 9.1 10.1 1.6 9.4 2.8 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal APG6_N PF17675.1 EDK37548.2 - 3.6 8.1 15.6 0.13 12.8 2.7 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 EDK37548.2 - 5.9 6.9 6.8 16 5.6 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PAP2 PF01569.21 EDK37549.2 - 3.3e-31 107.9 1.0 6.6e-31 106.9 1.0 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EDK37549.2 - 0.0065 16.2 4.4 0.0065 16.2 4.4 2.4 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EDK37549.2 - 0.23 12.0 2.6 0.22 12.1 0.4 2.2 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Aminotran_1_2 PF00155.21 EDK37550.1 - 2.1e-22 79.8 0.0 2.7e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDK37550.1 - 4.5e-06 25.7 0.0 6.2e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase PH_18 PF18469.1 EDK37552.2 - 4.8e-39 133.6 0.0 9.4e-39 132.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Rtt106 PF08512.12 EDK37552.2 - 1.3e-21 76.8 0.0 1.9e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DUF4746 PF15928.5 EDK37553.2 - 0.094 12.1 0.2 0.096 12.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SWIM PF04434.17 EDK37553.2 - 0.12 12.0 3.6 0.3 10.8 3.6 1.7 1 0 0 1 1 1 0 SWIM zinc finger UCH PF00443.29 EDK37554.2 - 3.7e-50 170.8 0.0 7.1e-50 169.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK37554.2 - 8.8e-11 42.0 0.0 7.9e-10 38.8 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase GREB1 PF15782.5 EDK37554.2 - 2.2 5.3 7.6 3.1 4.8 7.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Flocculin_t3 PF13928.6 EDK37555.1 - 0.00032 21.2 3.8 0.00032 21.2 3.8 3.9 3 1 0 3 3 3 1 Flocculin type 3 repeat YCII PF03795.14 EDK37556.2 - 2.6e-06 27.8 0.0 3.2e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Aldo_ket_red PF00248.21 EDK37557.2 - 1.3e-61 208.4 0.1 1.8e-61 207.9 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DsrD PF08679.11 EDK37557.2 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) POP1 PF06978.11 EDK37558.2 - 3.1e-73 246.2 8.0 5.1e-73 245.4 8.0 1.4 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EDK37558.2 - 7.4e-28 96.7 0.5 1.8e-27 95.5 0.5 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain Raptor_N PF14538.6 EDK37558.2 - 0.034 14.1 0.2 0.59 10.1 0.0 2.4 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain GCV_T_C PF08669.11 EDK37558.2 - 0.062 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain TauD PF02668.16 EDK37558.2 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family AIP3 PF03915.13 EDK37558.2 - 0.2 10.7 0.3 0.33 10.0 0.3 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Ssu72 PF04722.13 EDK37559.2 - 1.3e-81 272.8 0.8 1.5e-81 272.6 0.8 1.0 1 0 0 1 1 1 1 Ssu72-like protein gp45-slide_C PF09116.10 EDK37559.2 - 0.027 14.5 0.4 0.048 13.7 0.4 1.3 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal GIDA PF01134.22 EDK37559.2 - 0.043 12.9 0.0 0.054 12.6 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A G-patch PF01585.23 EDK37560.2 - 5.5e-11 42.2 1.5 1.6e-10 40.7 1.5 1.8 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 EDK37560.2 - 4.3e-05 23.4 0.0 0.00043 20.2 0.0 2.5 2 0 0 2 2 2 1 R3H domain G-patch_2 PF12656.7 EDK37560.2 - 0.13 12.4 0.6 0.53 10.4 0.6 2.1 1 0 0 1 1 1 0 G-patch domain Peptidase_C54 PF03416.19 EDK37561.2 - 2.1e-68 230.7 0.0 1.6e-67 227.8 0.0 2.0 1 1 0 1 1 1 1 Peptidase family C54 zf-C2H2_jaz PF12171.8 EDK37562.2 - 4.5e-11 42.7 10.8 5e-08 33.0 6.1 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EDK37562.2 - 5.5e-10 39.5 2.0 0.00028 21.2 0.2 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EDK37562.2 - 2.3e-08 34.1 9.7 1.3e-05 25.4 3.2 2.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EDK37562.2 - 5.5e-06 26.5 7.4 0.025 15.0 0.4 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK37562.2 - 7.1e-06 26.4 4.2 0.01 16.6 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger DUF2256 PF10013.9 EDK37562.2 - 0.0063 16.6 0.4 4.6 7.4 0.2 2.6 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_6 PF13912.6 EDK37562.2 - 0.0092 16.0 9.7 0.067 13.2 0.2 2.8 2 1 0 2 2 2 1 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EDK37562.2 - 0.041 13.5 1.9 3.7 7.3 0.1 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3449 PF11931.8 EDK37562.2 - 0.048 13.4 1.0 0.048 13.4 1.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3449) Zf_RING PF16744.5 EDK37562.2 - 0.21 11.7 1.4 3.2 7.9 0.3 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger zf-Di19 PF05605.12 EDK37562.2 - 0.22 11.8 1.7 2.2 8.6 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DnaJ PF00226.31 EDK37563.2 - 2.8e-24 85.0 0.1 8.3e-24 83.5 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain Rubrerythrin PF02915.17 EDK37563.2 - 0.1 13.0 0.3 0.1 13.0 0.3 2.3 1 1 1 2 2 2 0 Rubrerythrin DUF3295 PF11702.8 EDK37564.2 - 0.00033 20.2 13.1 0.00033 20.2 13.1 3.8 3 2 1 4 4 4 1 Protein of unknown function (DUF3295) Hydantoinase_B PF02538.14 EDK37565.2 - 6.5e-207 688.0 0.1 8.8e-207 687.6 0.1 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDK37565.2 - 1.8e-91 306.4 0.0 3.5e-91 305.5 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDK37565.2 - 3.9e-53 179.8 0.2 1.5e-50 171.3 0.0 2.7 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Retrotran_gag_2 PF14223.6 EDK37565.2 - 0.23 11.1 0.1 0.47 10.1 0.1 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type FAD_binding_3 PF01494.19 EDK37566.2 - 1.7e-11 44.0 0.2 4.2e-10 39.4 0.2 2.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDK37566.2 - 1.6e-07 31.4 0.4 3.6e-07 30.3 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK37566.2 - 3.3e-07 29.9 0.4 9.8e-07 28.3 0.0 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK37566.2 - 7.7e-06 25.7 0.8 5.8e-05 22.8 1.4 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDK37566.2 - 1.1e-05 24.7 0.0 1.6e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EDK37566.2 - 0.00016 21.2 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK37566.2 - 0.00021 20.5 1.1 0.00031 19.9 1.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EDK37566.2 - 0.0023 18.4 2.4 0.0032 18.0 0.7 2.2 3 0 0 3 3 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDK37566.2 - 0.0068 15.2 1.8 0.011 14.5 1.3 1.6 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 EDK37566.2 - 0.0073 15.6 1.0 0.15 11.3 0.0 2.4 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase SE PF08491.10 EDK37566.2 - 0.02 13.9 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase GIDA PF01134.22 EDK37566.2 - 0.033 13.3 1.9 0.066 12.3 1.9 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EDK37566.2 - 0.065 12.5 0.3 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain VanY PF02557.17 EDK37566.2 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Thi4 PF01946.17 EDK37566.2 - 0.15 11.3 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EDK37566.2 - 0.23 10.3 1.2 1.1 8.0 0.5 2.3 2 1 1 3 3 3 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EDK37566.2 - 0.26 10.5 1.6 1.4 8.1 0.9 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EDK37567.2 - 7.6e-11 41.5 1.6 7.6e-11 41.5 1.6 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37567.2 - 1e-07 31.9 11.7 1.7e-07 31.2 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDK37568.2 - 3.4e-23 82.2 21.7 4.7e-23 81.7 21.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK37568.2 - 0.00074 18.1 1.4 0.0011 17.5 1.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Strabismus PF06638.11 EDK37568.2 - 0.23 10.1 2.0 0.33 9.6 2.0 1.1 1 0 0 1 1 1 0 Strabismus protein Apolipoprotein PF01442.18 EDK37569.2 - 4.8e-05 23.3 21.0 0.00048 20.1 8.1 3.2 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EDK37569.2 - 0.25 12.0 0.1 0.25 12.0 0.1 5.1 1 1 3 5 5 5 0 Bacterial protein of unknown function (DUF883) DUF2937 PF11157.8 EDK37569.2 - 0.51 10.0 4.4 0.24 11.1 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) tRNA-synt_2b PF00587.25 EDK37570.2 - 3.7e-29 102.0 0.0 8.6e-29 100.8 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDK37570.2 - 3.6e-07 30.2 0.0 7.5e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain CBM_3 PF00942.18 EDK37570.2 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Cellulose binding domain RRM_1 PF00076.22 EDK37571.2 - 3.1e-07 30.1 0.0 1.6e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PBP1_TM PF14812.6 EDK37571.2 - 0.00023 21.4 2.5 0.00023 21.4 2.5 1.9 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 EDK37571.2 - 0.068 13.6 6.2 0.12 12.8 6.2 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EDK37571.2 - 0.33 10.2 6.8 0.54 9.5 6.8 1.3 1 0 0 1 1 1 0 NOA36 protein Shisa PF13908.6 EDK37572.2 - 0.00064 20.0 0.0 0.00096 19.5 0.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Corona_M PF01635.18 EDK37572.2 - 0.021 14.2 0.1 0.033 13.5 0.1 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein Orf78 PF06024.12 EDK37572.2 - 0.037 14.3 1.7 0.076 13.3 1.7 1.5 1 0 0 1 1 1 0 Orf78 (ac78) PMT_4TMC PF16192.5 EDK37572.2 - 0.065 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase DUF4834 PF16118.5 EDK37572.2 - 0.081 13.9 0.9 0.17 12.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 EDK37572.2 - 0.11 13.3 0.4 0.25 12.2 0.4 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3377 PF11857.8 EDK37572.2 - 0.18 11.7 3.1 0.43 10.5 3.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EDK37572.2 - 2.9 7.8 4.0 4.7 7.1 4.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family PP2C PF00481.21 EDK37573.2 - 3.8e-74 249.6 0.0 5.3e-74 249.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C MOZ_SAS PF01853.18 EDK37574.2 - 8.8e-72 240.5 0.9 1.2e-71 240.0 0.9 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDK37574.2 - 2.5e-20 71.8 2.8 5.2e-20 70.8 2.8 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 EDK37574.2 - 0.06 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C2H2_jaz PF12171.8 EDK37574.2 - 0.086 13.1 2.7 0.24 11.7 2.7 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding TatD_DNase PF01026.21 EDK37575.1 - 1.4e-43 149.1 0.0 2.3e-43 148.4 0.0 1.3 1 1 0 1 1 1 1 TatD related DNase DUF512 PF04459.12 EDK37575.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DnaJ PF00226.31 EDK37576.2 - 4.7e-07 29.8 1.0 7.8e-07 29.1 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain FPN1 PF06963.12 EDK37576.2 - 6.1 5.3 5.8 8.4 4.8 5.8 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) CemA PF03040.14 EDK37576.2 - 7 6.5 5.7 9.8 6.0 5.5 1.4 1 1 0 1 1 1 0 CemA family PTH2 PF01981.16 EDK37577.2 - 1.9e-44 150.7 0.3 2.7e-44 150.2 0.3 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF4611 PF15387.6 EDK37577.2 - 0.0025 18.0 0.8 0.005 17.0 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) Ribosomal_L5e PF17144.4 EDK37577.2 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 Myb_DNA-bind_6 PF13921.6 EDK37578.2 - 7.3e-10 39.0 0.9 5.4e-09 36.2 0.2 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDK37578.2 - 1.9e-08 34.3 2.5 3.2e-07 30.4 0.2 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EDK37578.2 - 0.12 12.7 0.1 0.3 11.4 0.1 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like SPAN-X PF07458.12 EDK37578.2 - 0.21 12.0 4.3 0.12 12.8 1.1 2.3 2 0 0 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome Chorismate_bind PF00425.18 EDK37579.2 - 1.4e-91 306.6 0.0 2.1e-91 306.0 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EDK37579.2 - 3.1e-31 108.5 1.3 6.7e-29 100.9 0.0 3.4 3 1 0 3 3 3 1 Anthranilate synthase component I, N terminal region DUF2312 PF10073.9 EDK37579.2 - 0.059 13.0 0.0 0.24 11.0 0.0 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) POR PF01558.18 EDK37579.2 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase RNB PF00773.19 EDK37580.2 - 0.00091 18.6 6.9 0.0039 16.6 0.0 3.5 4 1 0 4 4 4 2 RNB domain AMP-binding PF00501.28 EDK37581.2 - 8.6e-80 268.4 0.0 1.1e-79 268.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FAD-oxidase_C PF02913.19 EDK37582.2 - 3.9e-62 210.1 0.0 5.6e-62 209.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDK37582.2 - 4.7e-36 123.6 0.0 9.4e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain UPF0029 PF01205.19 EDK37583.2 - 1.1e-27 96.4 0.0 1.6e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Ribosomal_L14 PF00238.19 EDK37584.1 - 8.7e-49 164.7 0.8 9.7e-49 164.5 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e tRNA-synt_2b PF00587.25 EDK37585.1 - 4.2e-38 131.1 0.0 8.4e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDK37585.1 - 3.7e-18 65.5 1.1 2.5e-17 62.8 0.5 2.3 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 EDK37585.1 - 1.8e-13 50.4 0.0 4.6e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EDK37585.1 - 8.7e-09 35.3 0.0 4.4e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 TGS domain COMM_domain PF07258.14 EDK37585.1 - 1 9.5 2.8 2.4 8.3 0.2 2.7 3 0 0 3 3 3 0 COMM domain DUF1689 PF07954.11 EDK37586.2 - 1.9e-44 151.6 1.4 2.6e-44 151.2 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.14 EDK37587.2 - 1.2e-13 51.2 7.8 1.3e-12 47.8 7.8 2.3 1 1 0 1 1 1 1 Coatomer epsilon subunit ACDC PF14733.6 EDK37587.2 - 0.013 15.8 0.0 0.04 14.2 0.0 1.8 1 0 0 1 1 1 0 AP2-coincident C-terminal TPR_19 PF14559.6 EDK37587.2 - 0.02 15.4 0.1 0.2 12.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4724 PF15852.5 EDK37587.2 - 0.093 13.2 0.2 7.1 7.2 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4724) Septin PF00735.18 EDK37588.2 - 9.9e-82 274.4 1.3 9.9e-82 274.4 1.3 2.0 2 1 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDK37588.2 - 2.6e-07 30.7 0.0 5.7e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37588.2 - 3.7e-05 23.7 3.2 0.00016 21.6 0.1 2.5 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EDK37588.2 - 0.0003 20.4 0.1 0.064 12.8 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EDK37588.2 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.7 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 EDK37588.2 - 0.011 16.0 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EDK37588.2 - 0.015 14.8 0.4 0.064 12.8 0.1 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B IIGP PF05049.13 EDK37588.2 - 0.021 13.9 0.2 0.021 13.9 0.2 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 EDK37588.2 - 0.078 12.7 0.2 0.18 11.5 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDK37588.2 - 0.086 13.4 5.2 0.035 14.6 1.7 2.3 2 1 0 2 2 2 0 ABC transporter Dynamin_N PF00350.23 EDK37588.2 - 0.37 10.8 6.3 0.052 13.6 1.0 2.5 1 1 0 2 2 2 0 Dynamin family KRE9 PF05390.11 EDK37589.2 - 8.9e-35 119.5 15.3 8.9e-35 119.5 15.3 1.8 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 EDK37589.2 - 2e-13 50.9 0.5 2e-13 50.9 0.5 2.9 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4232 PF14016.6 EDK37589.2 - 0.041 14.0 1.4 3 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) DUF2369 PF10179.9 EDK37589.2 - 0.53 10.7 2.3 1.3 9.5 2.2 1.9 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Aldedh PF00171.22 EDK37590.2 - 2.2e-155 517.7 0.0 2.4e-155 517.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldo_ket_red PF00248.21 EDK37591.2 - 5.2e-64 216.3 0.0 6.1e-64 216.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Arginase PF00491.21 EDK37592.2 - 5.4e-88 295.1 0.2 7.1e-88 294.7 0.2 1.1 1 0 0 1 1 1 1 Arginase family WSC PF01822.19 EDK37593.2 - 1.9e-08 34.4 12.9 1.9e-08 34.4 12.9 2.6 2 1 0 2 2 1 1 WSC domain Podoplanin PF05808.11 EDK37593.2 - 0.0021 18.2 17.0 0.0049 17.0 17.0 1.6 1 1 0 1 1 1 1 Podoplanin Orf78 PF06024.12 EDK37593.2 - 0.005 17.1 0.1 0.13 12.6 0.0 2.3 1 1 1 2 2 2 1 Orf78 (ac78) EphA2_TM PF14575.6 EDK37593.2 - 0.0052 17.6 0.1 0.043 14.7 0.0 2.5 3 1 0 3 3 2 1 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 EDK37593.2 - 0.006 15.5 0.1 0.0091 14.9 0.1 1.3 1 0 0 1 1 1 1 Amnionless Apt1 PF10351.9 EDK37593.2 - 0.0078 15.1 11.5 0.01 14.7 11.5 1.3 1 0 0 1 1 1 1 Golgi-body localisation protein domain PPP4R2 PF09184.11 EDK37593.2 - 0.0096 15.5 5.3 0.013 15.1 5.3 1.1 1 0 0 1 1 1 1 PPP4R2 SKG6 PF08693.10 EDK37593.2 - 0.015 14.7 3.5 0.058 12.8 3.5 2.1 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Utp14 PF04615.13 EDK37593.2 - 0.02 13.5 5.9 0.024 13.2 5.9 1.2 1 0 0 1 1 1 0 Utp14 protein TMEM154 PF15102.6 EDK37593.2 - 0.03 14.2 0.1 0.03 14.2 0.1 2.4 1 1 1 2 2 1 0 TMEM154 protein family Plasmodium_Vir PF05795.11 EDK37593.2 - 0.081 12.3 6.3 0.11 11.8 6.3 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RIFIN PF02009.16 EDK37593.2 - 0.082 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Rifin GREB1 PF15782.5 EDK37593.2 - 0.29 8.2 11.4 0.31 8.1 11.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 EDK37593.2 - 0.38 9.9 19.1 0.52 9.4 19.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein QWRF PF04484.12 EDK37593.2 - 0.46 10.2 14.4 0.7 9.6 14.4 1.4 1 0 0 1 1 1 0 QWRF family Peptidase_S64 PF08192.11 EDK37593.2 - 0.98 7.8 14.8 1.2 7.5 14.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 EDK37593.2 - 2.1 6.9 9.7 2.6 6.6 9.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 EDK37593.2 - 2.9 6.6 7.3 3.8 6.2 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MAP65_ASE1 PF03999.12 EDK37593.2 - 3.7 6.1 9.3 4.4 5.9 9.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Hamartin PF04388.12 EDK37593.2 - 3.7 6.1 11.6 3.8 6.0 11.6 1.1 1 0 0 1 1 1 0 Hamartin protein DUF2408 PF10303.9 EDK37594.2 - 1.2e-50 171.5 25.8 1.8e-34 119.2 3.5 5.5 2 2 3 5 5 5 5 Protein of unknown function (DUF2408) Baculo_p24 PF05073.12 EDK37594.2 - 0.013 15.3 8.2 0.12 12.2 0.1 3.8 2 1 2 4 4 4 0 Baculovirus P24 capsid protein Flp_N PF03930.14 EDK37594.2 - 0.049 13.6 0.1 0.37 10.8 0.0 2.5 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus Hrs_helical PF12210.8 EDK37594.2 - 1.8 9.2 0.0 1.8 9.2 0.0 4.7 4 2 0 5 5 5 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Fez1 PF06818.15 EDK37594.2 - 2.5 8.5 15.3 17 5.8 8.8 3.0 2 1 0 2 2 2 0 Fez1 DUF489 PF04356.12 EDK37594.2 - 6.9 6.6 7.2 29 4.6 0.4 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF489) Cut8 PF08559.10 EDK37595.2 - 4.4e-78 262.2 4.4 5.3e-78 262.0 4.4 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein BING4CT PF08149.11 EDK37596.2 - 5.6e-36 122.2 0.0 3e-34 116.7 0.0 3.0 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EDK37596.2 - 1.1e-05 25.6 0.0 2.1 8.7 0.0 4.5 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK37596.2 - 2e-05 25.3 0.6 0.0019 19.0 0.0 3.9 5 0 0 5 5 5 1 WD domain, G-beta repeat VirArc_Nuclease PF12187.8 EDK37596.2 - 0.00011 21.8 0.1 0.00024 20.7 0.1 1.5 1 0 0 1 1 1 1 Viral/Archaeal nuclease DHO_dh PF01180.21 EDK37597.2 - 7e-97 324.2 0.0 8.5e-97 323.9 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EDK37597.2 - 0.018 14.1 0.5 0.23 10.5 0.2 2.5 2 1 0 2 2 2 0 FMN-dependent dehydrogenase DASH_Dam1 PF08653.10 EDK37598.2 - 3.6e-27 93.9 0.6 2.1e-26 91.5 0.1 2.1 2 0 0 2 2 2 1 DASH complex subunit Dam1 Leu_zip PF15294.6 EDK37598.2 - 0.00044 19.9 0.4 0.00071 19.2 0.1 1.5 2 0 0 2 2 2 1 Leucine zipper ZapB PF06005.12 EDK37598.2 - 0.0035 17.8 1.4 0.014 15.8 0.9 2.1 2 0 0 2 2 2 1 Cell division protein ZapB FlaC_arch PF05377.11 EDK37598.2 - 0.0042 17.4 0.4 3.6 8.1 0.4 2.3 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) HOOK PF05622.12 EDK37598.2 - 0.0081 14.4 0.2 0.018 13.2 0.1 1.4 2 0 0 2 2 2 1 HOOK protein Prefoldin PF02996.17 EDK37598.2 - 0.015 15.2 0.4 0.093 12.7 0.2 1.9 2 0 0 2 2 2 0 Prefoldin subunit Ax_dynein_light PF10211.9 EDK37598.2 - 0.023 14.7 1.3 0.098 12.6 0.9 1.9 2 0 0 2 2 2 0 Axonemal dynein light chain CCDC106 PF15794.5 EDK37598.2 - 0.028 14.1 0.3 0.028 14.1 0.3 1.5 2 0 0 2 2 1 0 Coiled-coil domain-containing protein 106 YabA PF06156.13 EDK37598.2 - 0.029 15.0 1.4 0.13 12.9 0.4 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 EDK37598.2 - 0.031 14.0 1.8 0.058 13.2 1.8 1.4 1 0 0 1 1 1 0 Septum formation initiator Med9 PF07544.13 EDK37598.2 - 0.045 13.8 2.1 0.045 13.8 2.1 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.12 EDK37598.2 - 0.058 14.0 1.9 0.24 12.0 0.7 2.3 2 0 0 2 2 2 0 SlyX HR1 PF02185.16 EDK37598.2 - 0.085 13.0 3.9 4.1 7.6 1.6 2.4 2 0 0 2 2 2 0 Hr1 repeat ABC_tran_CTD PF16326.5 EDK37598.2 - 0.089 13.1 0.7 0.9 9.8 0.4 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain GIT_CC PF16559.5 EDK37598.2 - 0.095 12.6 2.5 0.33 10.8 1.3 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor JIP_LZII PF16471.5 EDK37598.2 - 0.1 12.8 2.5 0.17 12.1 1.2 1.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II BLOC1_2 PF10046.9 EDK37598.2 - 0.11 12.8 0.7 6.4 7.1 0.2 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.18 EDK37598.2 - 0.12 12.7 1.0 0.24 11.8 0.2 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family SKA2 PF16740.5 EDK37598.2 - 0.13 12.0 1.1 0.33 10.7 0.4 1.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Seadorna_VP6 PF07407.11 EDK37598.2 - 0.14 11.1 0.2 0.19 10.6 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein DUF4988 PF16378.5 EDK37598.2 - 0.3 10.8 1.1 0.8 9.3 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function TolA_bind_tri PF16331.5 EDK37598.2 - 0.79 9.8 5.9 0.21 11.7 1.9 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation bZIP_2 PF07716.15 EDK37598.2 - 4 7.6 8.9 0.086 12.9 1.9 1.9 2 0 0 2 2 1 0 Basic region leucine zipper GET2 PF08690.10 EDK37599.2 - 5.1e-75 253.0 0.1 9.7e-75 252.1 0.1 1.4 1 1 0 1 1 1 1 GET complex subunit GET2 SURF1 PF02104.15 EDK37600.2 - 6e-42 143.9 0.0 8.7e-42 143.3 0.0 1.2 1 0 0 1 1 1 1 SURF1 family Utp14 PF04615.13 EDK37601.2 - 2.5 6.6 4.8 2.4 6.6 4.8 1.1 1 0 0 1 1 1 0 Utp14 protein Med10 PF09748.9 EDK37602.1 - 8.7e-37 125.8 0.1 1e-36 125.6 0.1 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Apo-CIII PF05778.12 EDK37603.2 - 0.076 12.7 0.2 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) PAN_2 PF08276.11 EDK37604.2 - 0.093 12.9 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 PAN-like domain CMD PF02627.20 EDK37605.2 - 4.3e-07 29.9 0.0 4.5e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family MFS_1 PF07690.16 EDK37606.2 - 5.2e-38 130.9 41.3 9.6e-38 130.0 27.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK37606.2 - 3.6e-11 42.6 25.3 9.9e-11 41.1 25.3 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDK37606.2 - 3e-05 22.7 0.7 4.7e-05 22.0 0.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EDK37606.2 - 0.0012 18.2 0.9 0.0012 18.2 0.9 2.7 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB SNARE PF05739.19 EDK37606.2 - 1.6 8.8 7.4 3.7 7.6 0.2 3.5 3 0 0 3 3 3 0 SNARE domain AFG1_ATPase PF03969.16 EDK37607.2 - 4.9e-62 209.9 0.4 5.3e-59 199.9 0.0 3.6 2 1 1 3 3 3 1 AFG1-like ATPase AAA_22 PF13401.6 EDK37607.2 - 0.017 15.4 0.0 0.15 12.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EDK37607.2 - 0.018 14.2 0.1 0.041 13.1 0.1 1.6 1 0 0 1 1 1 0 NB-ARC domain dNK PF01712.19 EDK37607.2 - 0.044 13.6 0.2 2.1 8.1 0.0 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase ABC_tran PF00005.27 EDK37607.2 - 0.048 14.2 0.4 3.2 8.3 0.0 2.8 2 1 1 3 3 3 0 ABC transporter NACHT PF05729.12 EDK37607.2 - 0.064 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EDK37607.2 - 0.067 13.6 0.0 0.23 11.8 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EDK37607.2 - 0.067 13.6 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EDK37607.2 - 0.077 13.4 0.3 1.2 9.6 0.0 3.0 4 0 0 4 4 4 0 RNA helicase AAA_29 PF13555.6 EDK37607.2 - 0.12 12.1 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Myotub-related PF06602.14 EDK37608.2 - 1.3e-141 471.6 0.8 1.7e-141 471.3 0.8 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain SAT PF16073.5 EDK37608.2 - 0.0039 17.0 0.1 0.0092 15.7 0.1 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Y_phosphatase PF00102.27 EDK37608.2 - 0.015 14.8 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EDK37608.2 - 0.019 15.0 0.0 0.064 13.2 0.0 1.9 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 EDK37608.2 - 0.091 12.6 0.1 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain TAT_signal PF10518.9 EDK37608.2 - 1.6 8.7 8.1 3.2 7.8 8.1 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Na_trans_assoc PF06512.13 EDK37609.2 - 4.3e-06 27.2 2.0 8e-06 26.3 0.1 2.3 2 1 0 2 2 2 1 Sodium ion transport-associated CDC45 PF02724.14 EDK37609.2 - 0.0018 16.7 19.8 0.0045 15.3 19.8 1.7 1 0 0 1 1 1 1 CDC45-like protein TFIIF_alpha PF05793.12 EDK37609.2 - 0.0019 16.9 25.9 0.0019 16.9 25.9 1.6 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EDK37609.2 - 0.0027 16.0 29.2 0.0027 16.0 29.2 1.5 2 0 0 2 2 2 1 Nop14-like family Drc1-Sld2 PF11719.8 EDK37609.2 - 0.0092 15.6 17.3 0.017 14.7 11.9 2.1 2 0 0 2 2 2 1 DNA replication and checkpoint protein ANAPC4_WD40 PF12894.7 EDK37609.2 - 0.036 14.4 1.6 3.3 8.1 0.0 4.1 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 EDK37609.2 - 0.078 12.4 42.1 0.021 14.3 36.8 2.2 2 0 0 2 2 2 0 SDA1 WD40 PF00400.32 EDK37609.2 - 0.29 12.1 3.9 0.52 11.3 0.1 3.5 5 0 0 5 5 5 0 WD domain, G-beta repeat Oxysterol_BP PF01237.18 EDK37610.2 - 4.4e-127 424.0 0.0 8e-127 423.1 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 EDK37610.2 - 4.1e-15 55.6 0.0 7.6e-08 32.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK37610.2 - 1.6e-13 49.5 0.1 6.3e-05 23.1 0.0 5.8 5 1 1 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EDK37610.2 - 5.7e-13 49.1 0.0 1.2e-08 35.4 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDK37610.2 - 6.9e-13 49.0 0.0 1.9e-08 34.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDK37610.2 - 5.8e-10 39.2 0.1 2.9e-05 24.3 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat PH PF00169.29 EDK37610.2 - 1.7e-08 34.9 0.5 3.8e-08 33.8 0.1 1.9 2 0 0 2 2 1 1 PH domain PH_8 PF15409.6 EDK37610.2 - 2.1e-07 31.1 0.3 5.5e-07 29.8 0.3 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain FAD_SOX PF18371.1 EDK37610.2 - 0.033 14.5 0.5 0.094 13.1 0.5 1.8 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase DUF3872 PF12988.7 EDK37610.2 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Lys-AminoMut_A PF09043.11 EDK37610.2 - 0.15 10.5 0.1 0.23 9.8 0.1 1.2 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit RRM_1 PF00076.22 EDK37611.2 - 2.1e-06 27.4 0.0 5.6e-06 26.1 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK37611.2 - 0.00041 19.9 0.0 0.00055 19.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK37611.2 - 0.0014 18.5 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Amino_oxidase PF01593.24 EDK37612.2 - 6.7e-25 88.3 0.0 1.6e-24 87.0 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDK37612.2 - 1.7e-14 53.8 0.0 4.3e-14 52.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDK37612.2 - 4e-07 29.5 0.0 2.1e-05 23.9 0.0 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EDK37612.2 - 2.1e-06 28.2 0.1 7.3e-05 23.2 0.0 3.3 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK37612.2 - 7.1e-06 25.8 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDK37612.2 - 0.0023 17.2 0.3 0.025 13.8 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 EDK37612.2 - 0.004 15.8 0.0 0.0079 14.8 0.0 1.5 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_9 PF13454.6 EDK37612.2 - 0.0067 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding MCRA PF06100.11 EDK37612.2 - 0.058 12.2 0.0 3.1 6.5 0.0 2.2 2 0 0 2 2 2 0 MCRA family Ubiquitin_2 PF14560.6 EDK37612.2 - 0.064 13.7 0.1 0.58 10.7 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain Arrestin_C PF02752.22 EDK37613.2 - 1.4e-13 51.5 3.5 1e-06 29.2 0.1 3.4 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDK37613.2 - 0.035 14.2 0.3 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain EF-hand_3 PF09069.11 EDK37613.2 - 0.17 12.3 0.0 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 EF-hand adh_short_C2 PF13561.6 EDK37616.2 - 1.7e-46 158.6 0.2 2.2e-46 158.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK37616.2 - 2.3e-43 147.9 1.0 2.8e-43 147.7 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK37616.2 - 3.4e-15 56.4 0.4 6e-15 55.6 0.4 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDK37616.2 - 0.005 16.0 0.0 0.0068 15.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF4972 PF16342.5 EDK37616.2 - 0.0076 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4972) F420_oxidored PF03807.17 EDK37616.2 - 0.039 14.5 0.1 0.15 12.7 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 EDK37616.2 - 0.073 12.5 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Kinesin PF00225.23 EDK37617.2 - 1.7e-106 356.0 1.3 2.9e-106 355.2 1.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDK37617.2 - 1.6e-27 96.3 0.0 4.8e-27 94.7 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DEAD PF00270.29 EDK37617.2 - 0.063 13.0 0.0 0.13 12.1 0.0 1.6 2 1 0 2 2 2 0 DEAD/DEAH box helicase DUF87 PF01935.17 EDK37617.2 - 0.79 9.8 10.4 1.4 9.0 0.1 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain DUF4407 PF14362.6 EDK37617.2 - 0.9 8.8 4.1 1.4 8.2 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EDK37617.2 - 2.1 9.0 9.9 65 4.2 0.1 4.1 2 1 2 4 4 4 0 SlyX Muted PF14942.6 EDK37617.2 - 5.2 7.4 15.9 1.9 8.8 11.9 2.4 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein Paralemmin PF03285.15 EDK37617.2 - 9.8 5.7 11.9 1.7 8.1 4.8 2.5 1 1 2 3 3 3 0 Paralemmin 2-Hacid_dh_C PF02826.19 EDK37618.2 - 2.4e-54 183.4 0.0 4.1e-54 182.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDK37618.2 - 1.2e-38 131.8 0.1 1.6e-38 131.4 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDK37618.2 - 5.6e-05 23.4 0.4 0.00015 21.9 0.4 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 EDK37618.2 - 0.00012 21.7 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 ACT domain AdoHcyase_NAD PF00670.21 EDK37618.2 - 0.00031 20.8 0.1 0.00067 19.8 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 EDK37618.2 - 0.017 15.6 0.0 0.055 14.0 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain IlvN PF07991.12 EDK37618.2 - 0.072 12.7 0.3 0.16 11.6 0.1 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DpaA_N PF16924.5 EDK37618.2 - 0.078 13.1 0.0 2.4 8.3 0.0 3.0 3 0 0 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain PC_rep PF01851.22 EDK37619.2 - 1.1e-15 57.2 9.2 1.1e-05 25.6 0.0 4.8 4 0 0 4 4 4 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDK37619.2 - 0.0017 18.7 0.0 0.41 11.1 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats Telomere_reg-2 PF10193.9 EDK37619.2 - 0.022 15.2 4.0 7.4 7.1 0.0 3.7 4 0 0 4 4 4 0 Telomere length regulation protein DUF2408 PF10303.9 EDK37619.2 - 0.064 13.8 0.3 0.29 11.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) DNA_alkylation PF08713.11 EDK37619.2 - 0.09 12.5 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 DNA alkylation repair enzyme TPR_6 PF13174.6 EDK37619.2 - 0.18 12.5 0.3 2.1e+02 2.9 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat RPN2_C PF18004.1 EDK37620.2 - 4.9e-55 185.8 6.7 6.7e-55 185.4 6.7 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EDK37620.2 - 3.7e-21 74.4 15.3 6.4e-06 26.3 0.0 5.3 6 0 0 6 6 6 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDK37620.2 - 1.1e-16 60.9 0.0 7.2e-16 58.4 0.0 2.2 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EDK37620.2 - 1.3e-06 28.2 0.0 0.21 12.0 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 EDK37620.2 - 0.00074 20.0 0.1 0.2 12.2 0.0 3.4 1 1 2 3 3 3 2 HEAT-like repeat HEAT_PBS PF03130.16 EDK37620.2 - 0.018 15.7 0.2 1.3 9.9 0.1 3.0 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat Cnd1 PF12717.7 EDK37620.2 - 0.055 13.5 0.0 2.6 8.1 0.0 2.5 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 PA26 PF04636.13 EDK37620.2 - 0.81 8.5 2.2 1.2 8.0 2.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Exo_endo_phos_2 PF14529.6 EDK37621.2 - 2e-07 30.8 0.4 6.9e-07 29.1 0.4 1.9 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EDK37621.2 - 3.1e-05 23.6 0.0 6.8e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ORC3_N PF07034.11 EDK37621.2 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus DAGK_cat PF00781.24 EDK37622.2 - 8.5e-25 86.8 0.0 1.3e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Cyclin PF08613.11 EDK37623.2 - 0.0033 17.8 0.0 0.55 10.6 0.0 3.0 2 1 0 2 2 2 2 Cyclin PCI PF01399.27 EDK37624.2 - 6.7e-10 39.4 1.8 3.9e-09 37.0 0.9 2.4 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EDK37624.2 - 0.0002 21.3 1.5 0.029 14.4 0.0 2.6 2 0 0 2 2 2 2 CSN8/PSMD8/EIF3K family Ecm29 PF13001.7 EDK37624.2 - 0.0027 16.5 0.0 0.44 9.2 0.0 2.4 2 1 0 2 2 2 2 Proteasome stabiliser V-ATPase_C PF03223.15 EDK37625.2 - 3.3e-115 385.4 0.6 3.8e-115 385.3 0.6 1.0 1 0 0 1 1 1 1 V-ATPase subunit C SURF6 PF04935.12 EDK37626.2 - 8.1e-49 166.1 44.5 8.1e-49 166.1 44.5 2.2 1 1 1 2 2 2 1 Surfeit locus protein 6 DUF1682 PF07946.14 EDK37626.2 - 0.0074 15.5 5.2 0.0074 15.5 5.2 4.6 4 2 0 4 4 4 1 Protein of unknown function (DUF1682) Adaptin_N PF01602.20 EDK37628.2 - 9.1e-122 407.3 2.1 1.1e-121 407.0 2.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EDK37628.2 - 2e-17 63.5 0.5 5.3e-17 62.1 0.5 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EDK37628.2 - 8.4e-08 32.4 1.9 0.0021 18.1 0.0 3.9 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDK37628.2 - 0.027 14.9 0.7 5.6 7.4 0.0 4.1 3 2 2 5 5 5 0 HEAT repeats ComR_TPR PF18710.1 EDK37628.2 - 0.33 10.5 1.3 0.79 9.2 0.3 2.1 3 0 0 3 3 3 0 ComR tetratricopeptide HEAT PF02985.22 EDK37628.2 - 0.76 10.2 2.5 92 3.7 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat Pro_isomerase PF00160.21 EDK37629.2 - 7.8e-09 36.0 0.1 7.8e-09 36.0 0.1 2.2 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Spore_coat_CotO PF14153.6 EDK37629.2 - 0.85 9.5 24.2 1.3 8.9 24.2 1.3 1 0 0 1 1 1 0 Spore coat protein CotO CDC45 PF02724.14 EDK37629.2 - 2.1 6.5 23.5 3 6.0 23.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 EDK37630.2 - 3.9e-37 128.0 0.1 2.6e-20 72.9 0.0 3.6 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37630.2 - 7e-13 48.5 0.0 0.0024 17.2 0.0 3.8 4 0 0 4 4 4 3 Protein tyrosine kinase FTA2 PF13095.6 EDK37630.2 - 0.02 14.5 0.0 0.074 12.7 0.0 2.0 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Acyltransferase PF01553.21 EDK37631.2 - 2.7e-16 59.4 0.0 6.1e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Gly_transf_sug PF04488.15 EDK37632.2 - 1.4e-20 73.8 0.0 2.5e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif RNase_PH PF01138.21 EDK37633.2 - 1.4e-20 74.2 0.0 2.2e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDK37633.2 - 4.3e-11 42.7 0.1 1e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Band_7 PF01145.25 EDK37634.2 - 3.1e-31 108.8 0.3 3.1e-31 108.8 0.3 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EDK37634.2 - 4.1e-27 94.0 0.1 9.1e-27 92.9 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 RLL PF10036.9 EDK37634.2 - 0.0082 16.0 0.9 0.012 15.5 0.9 1.2 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Band_7_1 PF13421.6 EDK37634.2 - 0.014 15.1 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family Pox_A11 PF05061.13 EDK37634.2 - 0.037 13.3 0.7 0.056 12.7 0.7 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein Apo-CIII PF05778.12 EDK37634.2 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) RNase_H2-Ydr279 PF09468.10 EDK37635.2 - 3e-23 82.8 0.9 3e-23 82.8 0.9 1.8 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EDK37635.2 - 3.6e-10 40.0 0.0 7.6e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain GCIP PF13324.6 EDK37635.2 - 0.02 14.5 0.8 0.036 13.7 0.8 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Rpp20 PF12328.8 EDK37635.2 - 0.91 9.5 5.1 2 8.4 5.1 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P LrgB PF04172.16 EDK37636.2 - 3.5e-52 177.1 3.1 5.2e-52 176.5 3.1 1.3 1 0 0 1 1 1 1 LrgB-like family zf-CHCC PF10276.9 EDK37638.1 - 5.8e-15 55.1 0.5 1.2e-14 54.0 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 EDK37638.1 - 0.082 12.6 0.3 0.63 9.8 0.1 2.4 2 0 0 2 2 2 0 Zinc Finger domain Ras PF00071.22 EDK37639.1 - 3.7e-57 192.4 0.0 4.3e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37639.1 - 2.7e-22 79.2 0.0 4.9e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37639.1 - 2.6e-08 33.5 0.0 4.1e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK37639.1 - 0.00027 20.6 0.0 0.00071 19.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDK37639.1 - 0.0037 17.2 0.2 0.017 15.1 0.0 2.2 2 1 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EDK37639.1 - 0.0074 15.7 0.0 0.013 15.0 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDK37639.1 - 0.021 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region tRNA_m1G_MT PF01746.21 EDK37640.2 - 5e-25 88.3 0.1 8.3e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Myb_DNA-bind_3 PF12776.7 EDK37640.2 - 0.07 14.1 2.7 9.7 7.3 0.1 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Aldo_ket_red PF00248.21 EDK37641.2 - 3.8e-62 210.1 0.0 4.3e-62 209.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ferritin PF00210.24 EDK37641.2 - 0.24 11.4 1.2 2.7 7.9 0.1 2.2 2 0 0 2 2 2 0 Ferritin-like domain Aldo_ket_red PF00248.21 EDK37642.2 - 1.2e-48 165.8 0.0 1.4e-48 165.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F_bP_aldolase PF01116.20 EDK37642.2 - 0.018 14.5 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Zn_clus PF00172.18 EDK37643.2 - 6.9e-06 26.1 12.6 6.9e-06 26.1 12.6 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK37643.2 - 1.1e-05 24.6 0.1 1.1e-05 24.6 0.1 2.5 4 0 0 4 4 4 1 Fungal specific transcription factor domain APC_u14 PF16635.5 EDK37643.2 - 0.22 12.1 3.8 0.97 10.0 3.8 2.1 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr Uds1 PF15456.6 EDK37643.2 - 0.49 10.6 3.9 0.33 11.1 1.3 2.1 2 0 0 2 2 2 0 Up-regulated During Septation Fungal_trans PF04082.18 EDK37644.2 - 1.9e-15 56.6 0.1 5.6e-15 55.1 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK37644.2 - 7.8e-08 32.3 10.1 1.4e-07 31.5 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4214 PF13946.6 EDK37644.2 - 0.026 14.6 0.1 0.058 13.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) ABC2_membrane PF01061.24 EDK37645.2 - 1.3e-40 139.1 22.3 1.3e-40 139.1 22.3 1.9 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 EDK37645.2 - 0.00025 20.9 0.1 0.0014 18.5 0.1 2.3 1 0 0 1 1 1 1 CDR ABC transporter Ferlin_C PF16165.5 EDK37645.2 - 0.019 14.9 0.4 0.087 12.8 0.0 2.1 2 0 0 2 2 2 0 Ferlin C-terminus PDR_CDR PF06422.12 EDK37646.2 - 1.2e-29 102.0 0.1 2.1e-29 101.3 0.1 1.4 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.27 EDK37646.2 - 1.3e-18 67.8 0.0 2.5e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EDK37646.2 - 3e-06 27.2 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EDK37646.2 - 1.8e-05 24.4 0.0 4.1e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK37646.2 - 6.2e-05 23.4 0.0 0.00012 22.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane PF01061.24 EDK37646.2 - 0.00017 21.1 0.7 0.00017 21.1 0.7 1.6 2 0 0 2 2 2 1 ABC-2 type transporter AAA_23 PF13476.6 EDK37646.2 - 0.0019 18.8 0.1 0.0048 17.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDK37646.2 - 0.0032 17.7 0.0 0.0053 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDK37646.2 - 0.0054 16.5 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EDK37646.2 - 0.0057 16.5 0.5 3 7.6 0.2 2.8 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDK37646.2 - 0.019 14.7 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain dNK PF01712.19 EDK37646.2 - 0.025 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_22 PF13401.6 EDK37646.2 - 0.046 14.0 0.0 0.09 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EDK37646.2 - 0.066 12.9 0.2 0.21 11.3 0.1 1.8 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family ABC_ATPase PF09818.9 EDK37646.2 - 0.079 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 EDK37646.2 - 0.11 12.6 0.2 0.23 11.6 0.2 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EDK37646.2 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EDK37646.2 - 0.15 11.7 0.3 0.27 10.8 0.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane PF01061.24 EDK37647.2 - 1.6e-09 37.5 2.0 2e-09 37.2 2.0 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EDK37648.2 - 8e-14 52.3 0.0 1.1e-13 51.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_17 PF13207.6 EDK37648.2 - 0.027 14.9 0.0 3.5 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDK37648.2 - 0.063 13.8 0.0 0.068 13.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK37648.2 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PQ-loop PF04193.14 EDK37649.2 - 1.3e-40 137.0 19.3 2.8e-22 78.2 1.7 2.9 3 0 0 3 3 3 2 PQ loop repeat PAP_PilO PF06864.12 EDK37649.2 - 0.15 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) AMP-binding PF00501.28 EDK37650.2 - 1.1e-64 218.7 0.0 2.3e-62 210.9 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme tRNA_int_end_N2 PF12928.7 EDK37651.2 - 5.3e-17 61.8 0.1 9.3e-17 61.0 0.1 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term COMPASS-Shg1 PF05205.12 EDK37651.2 - 0.1 13.3 4.1 0.3 11.8 4.1 1.7 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Coiled-coil_56 PF09813.9 EDK37651.2 - 0.11 12.5 0.4 0.22 11.6 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Smg4_UPF3 PF03467.15 EDK37654.2 - 1.1e-17 64.6 32.9 4.6e-16 59.3 32.9 2.8 1 1 0 1 1 1 1 Smg-4/UPF3 family PCI PF01399.27 EDK37655.2 - 1.1e-05 25.8 0.1 3.8e-05 24.1 0.1 1.9 2 0 0 2 2 2 1 PCI domain F-box-like PF12937.7 EDK37656.2 - 0.0064 16.4 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 F-box-like Ferric_reduct PF01794.19 EDK37658.2 - 2e-18 66.7 12.4 6.7e-18 65.0 10.9 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DbpA PF03880.15 EDK37658.2 - 0.15 12.1 0.0 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain CDC45 PF02724.14 EDK37658.2 - 0.16 10.3 0.9 0.22 9.8 0.9 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-CCHC PF00098.23 EDK37659.2 - 0.00018 21.5 40.6 0.0027 17.7 2.0 4.9 5 1 0 5 5 5 4 Zinc knuckle zf-C2H2_10 PF16588.5 EDK37659.2 - 0.12 12.2 17.6 0.11 12.2 4.8 3.2 3 0 0 3 3 3 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 EDK37659.2 - 1.9 8.3 31.4 0.91 9.3 2.0 5.2 4 1 1 5 5 5 0 Zinc knuckle Cg6151-P PF10233.9 EDK37660.2 - 2.3e-43 147.1 13.5 3e-43 146.7 13.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P COPI_assoc PF08507.10 EDK37660.2 - 0.0027 17.7 10.2 0.0041 17.2 10.2 1.3 1 0 0 1 1 1 1 COPI associated protein YwiC PF14256.6 EDK37660.2 - 0.039 14.3 3.5 3.2 8.1 0.2 2.1 2 0 0 2 2 2 0 YwiC-like protein SLATT_1 PF18181.1 EDK37660.2 - 0.077 12.9 2.3 0.23 11.4 0.4 2.1 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Clc-like PF07062.12 EDK37660.2 - 0.34 10.4 8.1 0.72 9.3 8.0 1.5 1 1 0 1 1 1 0 Clc-like YtpI PF14007.6 EDK37660.2 - 0.7 10.1 16.7 0.24 11.5 0.5 2.9 2 1 1 3 3 3 0 YtpI-like protein DUF5592 PF17332.2 EDK37660.2 - 3.5 8.2 7.7 0.44 11.1 2.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5592) DUF202 PF02656.15 EDK37660.2 - 4.2 7.9 8.0 9.7 6.7 2.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF5090 PF17009.5 EDK37660.2 - 4.4 7.2 10.5 0.41 10.6 4.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5090) MMR_HSR1_C PF08438.10 EDK37661.2 - 6.2e-35 120.1 0.0 1e-34 119.5 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EDK37661.2 - 4.6e-20 71.8 0.0 1.3e-19 70.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK37661.2 - 5.4e-10 39.0 0.4 1.3e-07 31.3 0.1 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDK37661.2 - 0.00074 19.5 0.3 0.92 9.4 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDK37661.2 - 0.0029 17.2 0.8 0.15 11.6 0.0 2.8 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDK37661.2 - 0.0052 16.9 0.1 0.016 15.3 0.0 1.8 2 0 0 2 2 2 1 Dynamin family ABC_tran PF00005.27 EDK37661.2 - 0.013 16.0 0.0 0.12 12.9 0.0 2.3 3 0 0 3 3 3 0 ABC transporter AAA_28 PF13521.6 EDK37661.2 - 0.018 15.3 0.1 0.046 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EDK37661.2 - 0.079 12.7 0.3 6.5 6.5 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ploopntkinase3 PF18751.1 EDK37661.2 - 0.081 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_22 PF13401.6 EDK37661.2 - 0.1 12.9 0.0 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDK37661.2 - 0.11 12.8 0.1 0.68 10.3 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EDK37661.2 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CRAL_TRIO PF00650.20 EDK37662.2 - 3.5e-19 69.1 0.1 8.5e-19 67.8 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK37662.2 - 0.0096 16.1 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Prok_Ub PF14454.6 EDK37662.2 - 0.14 11.8 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DnaJ PF00226.31 EDK37663.2 - 3.1e-21 75.3 2.6 3.1e-21 75.3 2.6 3.0 3 0 0 3 3 3 2 DnaJ domain PigN PF04987.14 EDK37664.2 - 2.1e-85 287.3 25.4 3e-85 286.8 25.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EDK37664.2 - 2.9e-11 43.6 1.0 3.6e-09 36.7 0.3 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDK37664.2 - 2.7e-08 33.6 0.1 8e-08 32.0 0.1 1.8 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EDK37664.2 - 3.2e-05 23.4 0.0 5.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF4231 PF14015.6 EDK37664.2 - 6.1 7.4 5.3 14 6.2 2.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) IGPS PF00218.21 EDK37665.2 - 1.9e-73 246.7 0.0 2.6e-73 246.3 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 EDK37665.2 - 1.1e-41 142.8 0.0 1.7e-41 142.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDK37665.2 - 5.5e-07 29.6 0.2 1.4e-06 28.3 0.2 1.6 1 1 0 1 1 1 1 Peptidase C26 Rep_fac-A_3 PF08661.11 EDK37666.2 - 1.5e-24 86.3 0.1 1.7e-24 86.2 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1_2 PF15490.6 EDK37666.2 - 0.00044 19.9 0.0 0.00071 19.3 0.0 1.4 1 1 0 1 1 1 1 Telomere-capping, CST complex subunit PFU PF09070.11 EDK37667.2 - 2.4e-38 130.9 0.0 4.4e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 EDK37667.2 - 2.3e-33 115.6 0.1 2.9e-33 115.3 0.1 1.1 1 0 0 1 1 1 1 PUL domain HTH_Tnp_1_2 PF13022.6 EDK37667.2 - 0.032 14.4 0.0 0.06 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase WD40 PF00400.32 EDK37668.2 - 2e-32 110.7 12.2 3.3e-05 24.6 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat WD40_like PF17005.5 EDK37668.2 - 5.3e-07 29.3 0.0 4e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 EDK37668.2 - 0.0043 17.1 0.0 11 6.1 0.0 3.7 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EDK37668.2 - 0.026 14.8 0.1 0.11 12.8 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Syja_N PF02383.18 EDK37669.1 - 1e-58 199.2 0.6 1.5e-58 198.6 0.6 1.3 1 0 0 1 1 1 1 SacI homology domain Tenui_NCP PF04876.12 EDK37670.1 - 0.13 11.8 0.0 0.53 9.8 0.0 1.8 2 0 0 2 2 2 0 Tenuivirus major non-capsid protein MFS_1 PF07690.16 EDK37671.1 - 1.1e-09 37.7 3.9 1.1e-09 37.7 3.9 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK37672.1 - 6.4e-16 58.2 19.1 9.9e-16 57.6 19.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK37672.1 - 1.1e-06 27.8 4.9 1.4e-06 27.4 4.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter PNTB PF02233.16 EDK37672.1 - 0.17 10.8 0.5 0.25 10.2 0.5 1.2 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit Ribonucleas_3_3 PF14622.6 EDK37673.2 - 1.9e-08 34.5 1.6 4.4e-08 33.4 1.4 1.7 2 0 0 2 2 2 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EDK37673.2 - 0.00013 22.6 0.9 0.00027 21.5 0.2 2.0 2 0 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.26 EDK37673.2 - 0.0057 17.3 0.0 0.43 11.3 0.0 2.5 2 0 0 2 2 2 1 Double-stranded RNA binding motif RNase_3_N PF18497.1 EDK37673.2 - 0.044 14.0 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 Ribonuclease III N-terminal domain Mito_carr PF00153.27 EDK37674.1 - 1.1e-42 143.9 7.9 5.5e-17 61.5 0.5 3.2 2 1 0 3 3 3 3 Mitochondrial carrier protein RNA_polI_A34 PF08208.11 EDK37676.2 - 1.7e-34 119.7 25.6 1.7e-34 119.7 25.6 1.3 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 GAGA_bind PF06217.12 EDK37676.2 - 0.055 13.8 9.7 0.063 13.5 9.7 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CPSF100_C PF13299.6 EDK37676.2 - 1.1 9.4 12.1 2.1 8.5 12.1 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 EDK37676.2 - 3 6.7 7.9 3.5 6.5 7.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GNAT_acetyltr_2 PF13718.6 EDK37676.2 - 4.5 6.6 11.8 12 5.3 0.0 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Presenilin PF01080.17 EDK37676.2 - 5.2 5.7 12.6 6.8 5.3 12.6 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EDK37676.2 - 5.5 5.2 17.1 8 4.6 17.1 1.3 1 0 0 1 1 1 0 CDC45-like protein RraA-like PF03737.15 EDK37678.2 - 8.4e-33 113.6 0.0 1.1e-32 113.3 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA Pkinase PF00069.25 EDK37680.2 - 1.7e-71 240.7 0.0 2.2e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37680.2 - 1.3e-39 136.0 0.0 1.9e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK37680.2 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDK37680.2 - 0.013 14.5 0.6 0.022 13.7 0.1 1.6 1 1 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EDK37680.2 - 0.095 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDK37681.2 - 7.8e-32 110.7 0.0 3.4e-31 108.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37681.2 - 1.2e-13 51.0 0.0 2.4e-13 50.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase TcdB_toxin_midC PF12255.8 EDK37681.2 - 0.034 14.2 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/C-terminal region Kdo PF06293.14 EDK37681.2 - 0.035 13.5 0.0 0.066 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1647 PF07801.11 EDK37681.2 - 0.11 12.2 0.1 0.3 10.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) YL1 PF05764.13 EDK37681.2 - 3.4 7.7 10.4 0.87 9.6 3.3 2.5 2 0 0 2 2 2 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 EDK37681.2 - 5.4 6.7 15.0 3.3 7.4 0.2 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pkinase PF00069.25 EDK37682.2 - 4.7e-68 229.4 0.4 7.9e-68 228.7 0.4 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37682.2 - 4.6e-52 176.9 0.1 7.2e-52 176.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDK37682.2 - 7.4e-23 80.7 0.3 7.4e-23 80.7 0.3 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.29 EDK37682.2 - 4.3e-11 43.3 0.2 1.3e-10 41.7 0.1 1.9 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.6 EDK37682.2 - 3.2e-07 30.0 0.0 5.9e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDK37682.2 - 2e-06 26.9 0.0 3.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EDK37682.2 - 3.6e-05 22.9 0.0 6.7e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain PH_9 PF15410.6 EDK37682.2 - 0.00015 22.1 0.2 0.00044 20.6 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EDK37682.2 - 0.00079 19.8 0.0 0.0027 18.1 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain Seadorna_VP7 PF07387.11 EDK37682.2 - 0.0057 15.7 0.2 0.011 14.8 0.2 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EDK37682.2 - 0.0066 16.4 0.2 0.034 14.1 0.2 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family Gti1_Pac2 PF09729.9 EDK37683.2 - 2e-48 164.9 12.7 3.3e-45 154.4 0.1 3.2 2 2 1 3 3 3 2 Gti1/Pac2 family F-box-like PF12937.7 EDK37684.2 - 3.8e-08 33.1 0.2 3.8e-08 33.1 0.2 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDK37684.2 - 9.6e-06 25.3 3.4 1.5e-05 24.7 0.7 2.6 2 0 0 2 2 2 1 F-box domain Period_C PF12114.8 EDK37684.2 - 0.071 12.7 4.9 0.16 11.6 4.9 1.5 1 0 0 1 1 1 0 Period protein 2/3C-terminal region TFA2_Winged_2 PF18121.1 EDK37685.2 - 3e-19 68.4 0.0 5.6e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EDK37685.2 - 1.7e-18 66.7 0.4 3.7e-18 65.6 0.4 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain NTF2 PF02136.20 EDK37686.1 - 3.5e-24 85.7 0.0 3.8e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF1840 PF08895.11 EDK37687.2 - 1.7 9.0 8.9 10 6.5 5.1 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) cwf21 PF08312.12 EDK37688.2 - 2.7e-12 46.6 4.4 2.7e-12 46.6 4.4 2.7 3 0 0 3 3 3 1 cwf21 domain TRIQK PF15168.6 EDK37688.2 - 0.13 12.2 0.8 0.24 11.3 0.8 1.4 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Mannosyl_trans3 PF11051.8 EDK37689.2 - 9.7e-84 281.0 0.0 1.4e-83 280.4 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Aldo_ket_red PF00248.21 EDK37690.2 - 2.9e-38 131.8 0.1 1.8e-36 125.8 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family GntR PF00392.21 EDK37690.2 - 0.014 15.0 0.0 1.7 8.4 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Potyvirid-P3 PF13608.6 EDK37690.2 - 0.12 11.4 0.0 0.61 9.0 0.0 1.8 2 0 0 2 2 2 0 Protein P3 of Potyviral polyprotein Maf1 PF09174.10 EDK37691.2 - 1.5e-27 96.8 8.8 4e-19 69.4 0.1 2.4 2 0 0 2 2 2 2 Maf1 regulator Rad51 PF08423.11 EDK37692.2 - 1e-30 106.9 0.3 6.9e-29 100.9 0.0 2.5 2 1 0 2 2 2 1 Rad51 ATPase PF06745.13 EDK37692.2 - 7e-09 35.4 2.5 2.2e-08 33.7 0.7 2.6 2 1 0 2 2 2 1 KaiC AAA_25 PF13481.6 EDK37692.2 - 6.2e-05 22.7 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 EDK37692.2 - 0.0026 17.6 0.1 1.2 8.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial dnaA protein RecA PF00154.21 EDK37692.2 - 0.0033 16.9 0.0 0.0056 16.2 0.0 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ABC_tran PF00005.27 EDK37692.2 - 0.024 15.1 0.1 0.32 11.5 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 EDK37692.2 - 0.062 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDK37692.2 - 0.065 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PhoH PF02562.16 EDK37692.2 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 EDK37692.2 - 0.12 12.6 0.1 0.37 11.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain Pyr_redox_2 PF07992.14 EDK37693.2 - 1.4e-22 80.3 0.1 1.9e-22 79.9 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK37693.2 - 5e-05 23.8 0.0 9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK37693.2 - 0.00033 20.0 0.0 0.00054 19.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK37693.2 - 0.025 13.7 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyrophosphatase PF00719.19 EDK37694.2 - 2.1e-59 199.9 0.2 2.8e-59 199.5 0.2 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase TP6A_N PF04406.14 EDK37695.2 - 3e-14 52.8 0.5 5.1e-14 52.0 0.5 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase RCR PF12273.8 EDK37696.1 - 7.7e-35 120.1 14.5 1.8e-33 115.7 14.5 2.3 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF2167 PF09935.9 EDK37696.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) RSN1_7TM PF02714.15 EDK37697.2 - 5.6e-83 278.4 27.6 7.9e-83 277.9 23.8 2.3 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDK37697.2 - 4.3e-43 146.8 1.3 4.3e-43 146.8 1.3 3.0 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDK37697.2 - 5e-27 95.3 0.3 1.4e-26 93.8 0.3 1.8 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDK37697.2 - 9e-25 86.7 0.2 3.4e-24 84.8 0.3 1.9 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter FAM176 PF14851.6 EDK37697.2 - 0.1 12.3 0.1 0.35 10.5 0.1 1.8 1 0 0 1 1 1 0 FAM176 family TraS PF10624.9 EDK37697.2 - 8.1 6.3 10.7 0.43 10.5 1.9 3.0 3 0 0 3 3 3 0 Plasmid conjugative transfer entry exclusion protein TraS HMGL-like PF00682.19 EDK37699.1 - 1.4e-71 241.2 0.0 2e-71 240.7 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EDK37699.1 - 3.9e-26 91.5 0.0 6.5e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Sugar_tr PF00083.24 EDK37700.2 - 9.3e-56 189.6 23.8 1.5e-55 188.9 23.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37700.2 - 6.6e-19 68.0 51.7 1.2e-15 57.3 29.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DMT_YdcZ PF04657.13 EDK37700.2 - 0.0048 17.2 2.9 0.0048 17.2 2.9 3.9 4 0 0 4 4 4 2 Putative inner membrane exporter, YdcZ Syja_N PF02383.18 EDK37701.2 - 1.4e-45 156.0 0.0 2.5e-45 155.2 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDK37701.2 - 3.3e-08 33.3 0.0 5.8e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Trm112p PF03966.16 EDK37704.1 - 1.8e-19 70.0 0.0 2.5e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.6 EDK37704.1 - 0.07 13.7 0.4 0.15 12.6 0.4 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Pkinase PF00069.25 EDK37705.2 - 7.7e-76 254.9 0.1 1.1e-75 254.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37705.2 - 9.9e-32 110.2 0.1 1e-22 80.7 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDK37705.2 - 1.5e-07 31.0 0.1 0.11 11.8 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EDK37705.2 - 0.0012 17.8 0.4 0.0042 15.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EDK37705.2 - 0.025 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIR PF00399.19 EDK37706.1 - 2.2e-09 36.6 82.5 1.8e-05 24.2 4.5 7.4 6 1 1 7 7 7 6 Yeast PIR protein repeat zf-C2H2 PF00096.26 EDK37707.2 - 5.6e-09 36.0 13.9 0.00027 21.2 0.5 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK37707.2 - 1.6e-05 25.3 11.4 0.0032 18.2 1.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK37707.2 - 0.00012 22.3 0.4 0.00012 22.3 0.4 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDK37707.2 - 0.00032 21.0 0.5 0.00032 21.0 0.5 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Zn-C2H2_12 PF18112.1 EDK37707.2 - 0.021 15.3 0.6 0.1 13.1 0.6 2.3 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-H2C2_2 PF13465.6 EDK37707.2 - 0.035 14.5 1.0 0.035 14.5 1.0 4.1 4 0 0 4 4 4 0 Zinc-finger double domain zf-Di19 PF05605.12 EDK37707.2 - 0.095 13.0 3.3 21 5.5 0.3 2.3 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 EDK37707.2 - 0.17 11.8 0.6 0.4 10.6 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 EDK37707.2 - 0.43 10.5 8.2 3 7.8 0.6 2.6 2 1 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 EDK37707.2 - 0.46 10.5 2.8 0.24 11.5 0.5 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Ank_2 PF12796.7 EDK37708.2 - 3.1e-14 53.3 1.1 1.9e-08 34.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK37708.2 - 9.7e-11 42.0 4.5 2.9e-06 27.7 0.3 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EDK37708.2 - 3.5e-07 30.4 6.5 0.12 12.8 0.2 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EDK37708.2 - 6.7e-07 29.1 3.2 0.042 14.4 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EDK37708.2 - 0.00028 21.1 1.0 0.17 12.3 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) NikR_C PF08753.11 EDK37708.2 - 0.31 11.2 0.1 0.31 11.2 0.1 1.6 2 0 0 2 2 2 0 NikR C terminal nickel binding domain MutS_V PF00488.21 EDK37709.2 - 4.9e-68 228.9 0.1 1.2e-67 227.6 0.1 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDK37709.2 - 8.5e-34 117.4 1.1 2.4e-33 116.0 0.4 2.0 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EDK37709.2 - 2.1e-29 102.1 0.1 8.6e-29 100.1 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EDK37709.2 - 5.9e-06 26.6 0.2 3.7e-05 24.0 0.0 2.6 2 1 0 2 2 2 1 MutS domain II AAA_14 PF13173.6 EDK37709.2 - 0.021 14.9 0.1 0.17 11.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain MtrG PF04210.13 EDK37709.2 - 0.088 12.7 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Fe-ADH PF00465.19 EDK37709.2 - 0.19 10.5 0.0 0.79 8.5 0.0 1.8 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Abhydrolase_1 PF00561.20 EDK37710.2 - 4.5e-16 59.3 0.0 1.9e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK37710.2 - 9.8e-09 36.1 0.0 5.8e-08 33.6 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK37710.2 - 3.7e-08 32.9 0.0 8.6e-07 28.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EDK37710.2 - 0.00013 21.4 0.2 0.00029 20.2 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 EDK37710.2 - 0.0012 18.4 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Palm_thioest PF02089.15 EDK37710.2 - 0.002 18.0 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF900 PF05990.12 EDK37710.2 - 0.13 11.7 0.0 0.58 9.6 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Pmp3 PF01679.17 EDK37712.1 - 1.8e-19 69.7 6.5 2.8e-19 69.1 6.5 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator TUG-UBL1 PF11470.8 EDK37713.2 - 9.9e-17 60.9 0.1 2.7e-16 59.5 0.1 1.8 1 0 0 1 1 1 1 TUG ubiquitin-like domain ubiquitin PF00240.23 EDK37713.2 - 0.02 14.7 0.7 0.048 13.4 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family bZIP_1 PF00170.21 EDK37714.2 - 1e-09 38.3 10.7 2.2e-09 37.2 10.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDK37714.2 - 1.6e-09 37.7 5.5 3.1e-09 36.8 5.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDK37714.2 - 0.014 15.9 4.6 0.014 15.9 4.6 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor Ten1 PF12658.7 EDK37714.2 - 0.12 12.3 0.2 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 Telomere capping, CST complex subunit HeH PF12949.7 EDK37714.2 - 0.12 12.1 0.1 0.3 10.8 0.1 1.6 1 0 0 1 1 1 0 HeH/LEM domain RRM_1 PF00076.22 EDK37715.2 - 1.1e-15 57.2 1.8 8e-11 41.6 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK37715.2 - 3.8e-05 23.3 0.3 6.2e-05 22.6 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VIT1 PF01988.19 EDK37716.2 - 3.1e-63 213.5 1.5 4.7e-63 212.9 1.5 1.3 1 0 0 1 1 1 1 VIT family Band_7 PF01145.25 EDK37717.2 - 3.3e-23 82.6 6.1 5.7e-23 81.8 6.1 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EDK37717.2 - 0.0034 16.5 3.8 0.0044 16.1 3.8 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial Atg14 PF10186.9 EDK37717.2 - 0.069 12.2 2.2 0.097 11.7 2.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Peptidase_M24 PF00557.24 EDK37718.2 - 1.2e-55 188.4 0.0 1.6e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EDK37718.2 - 4e-35 120.2 0.0 8.3e-35 119.2 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Zein-binding PF04576.15 EDK37718.2 - 0.0072 16.6 0.3 0.014 15.7 0.3 1.5 1 0 0 1 1 1 1 Zein-binding Peptidase_C48 PF02902.19 EDK37719.2 - 1.5e-09 38.0 2.5 7e-09 35.8 2.5 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Tmemb_170 PF10190.9 EDK37721.2 - 3.2e-12 46.7 15.8 4.7e-12 46.2 15.8 1.3 1 0 0 1 1 1 1 Putative transmembrane protein 170 Proteasome PF00227.26 EDK37722.2 - 8.4e-60 201.5 0.2 1e-59 201.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDK37722.2 - 2.4e-13 49.5 0.3 4.1e-13 48.7 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature NCA2 PF08637.10 EDK37723.2 - 4.8e-90 301.6 1.6 4.8e-90 301.6 1.6 2.0 2 1 0 2 2 2 1 ATP synthase regulation protein NCA2 zf-C2H2 PF00096.26 EDK37724.2 - 7.9e-11 41.8 8.9 5.5e-05 23.4 0.3 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK37724.2 - 1.4e-07 31.7 7.6 0.00092 19.9 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger Actin_micro PF17003.5 EDK37724.2 - 0.0015 17.8 0.0 0.0054 16.0 0.0 1.8 1 1 0 1 1 1 1 Putative actin-like family zf-C2H2_jaz PF12171.8 EDK37724.2 - 0.0016 18.7 0.6 0.26 11.6 0.9 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Sporozoite_P67 PF05642.11 EDK37724.2 - 0.0019 16.4 0.4 0.0019 16.4 0.4 1.9 2 0 0 2 2 2 1 Sporozoite P67 surface antigen zf-H2C2_2 PF13465.6 EDK37724.2 - 0.0042 17.4 9.4 0.21 12.1 1.5 3.1 3 0 0 3 3 3 2 Zinc-finger double domain DASH_Spc19 PF08287.11 EDK37724.2 - 0.0062 16.4 0.8 0.011 15.6 0.8 1.4 1 0 0 1 1 1 1 Spc19 DUF2321 PF10083.9 EDK37724.2 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_6 PF13912.6 EDK37724.2 - 0.022 14.8 4.7 0.079 13.0 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EDK37724.2 - 0.023 15.1 0.8 9.7 6.7 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EDK37724.2 - 0.04 14.2 0.6 0.078 13.3 0.6 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 EDK37724.2 - 0.074 13.7 1.6 1.2 9.8 0.2 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats C1_2 PF03107.16 EDK37724.2 - 0.13 12.6 2.3 9.3 6.7 0.3 2.4 2 0 0 2 2 2 0 C1 domain DUF2256 PF10013.9 EDK37724.2 - 0.13 12.4 1.2 6.2 7.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_C2H2_ZHX PF18387.1 EDK37724.2 - 0.14 11.8 3.4 7.4 6.3 0.0 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain KRTDAP PF15200.6 EDK37724.2 - 0.14 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Keratinocyte differentiation-associated LIM PF00412.22 EDK37724.2 - 0.24 11.6 1.5 0.47 10.7 1.5 1.4 1 0 0 1 1 1 0 LIM domain FAM176 PF14851.6 EDK37724.2 - 0.49 10.0 4.2 0.12 12.1 0.9 1.7 2 0 0 2 2 2 0 FAM176 family DUF629 PF04780.12 EDK37724.2 - 0.65 8.5 3.9 7.1 5.0 3.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF629) DUF4637 PF15470.6 EDK37724.2 - 1.4 8.6 7.9 0.73 9.5 4.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) zf-met2 PF12907.7 EDK37724.2 - 1.8 8.8 4.1 28 5.0 0.0 2.4 2 0 0 2 2 2 0 Zinc-binding DUF4820 PF16091.5 EDK37724.2 - 3.4 7.0 6.9 0.75 9.1 3.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4820) FF PF01846.19 EDK37725.2 - 0.0014 18.8 1.1 0.0014 18.8 1.1 3.8 2 2 0 2 2 2 1 FF domain WW PF00397.26 EDK37725.2 - 0.014 15.5 1.6 0.036 14.2 1.6 1.8 1 0 0 1 1 1 0 WW domain BUD22 PF09073.10 EDK37725.2 - 0.31 10.3 14.0 0.43 9.9 14.0 1.2 1 0 0 1 1 1 0 BUD22 RP-C_C PF11800.8 EDK37725.2 - 0.92 9.6 8.8 0.48 10.5 4.8 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region MbeB_N PF04837.12 EDK37725.2 - 7.3 7.0 6.3 23 5.4 1.1 3.0 3 0 0 3 3 3 0 MbeB-like, N-term conserved region ketoacyl-synt PF00109.26 EDK37726.2 - 1.4e-58 198.5 0.5 4.1e-58 196.9 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EDK37726.2 - 3.3e-35 120.7 1.2 6.4e-35 119.7 1.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EDK37726.2 - 9.7e-05 21.8 0.3 0.00021 20.8 0.0 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain SKN1 PF03935.15 EDK37727.2 - 4.2e-250 830.3 7.2 5.1e-250 830.1 7.2 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) APG9 PF04109.16 EDK37728.2 - 5.2e-182 606.1 17.1 6.3e-182 605.9 17.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Poxvirus_B22R PF04395.12 EDK37728.2 - 0.02 14.5 0.2 0.097 12.2 0.3 1.9 2 0 0 2 2 2 0 Poxvirus B22R protein Nop14 PF04147.12 EDK37729.2 - 1.3e-158 529.9 62.2 1.9e-100 337.4 14.9 3.0 1 1 1 2 2 2 2 Nop14-like family MARVEL PF01284.23 EDK37730.2 - 2e-30 105.7 18.6 2.3e-30 105.5 18.6 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.12 EDK37730.2 - 0.054 13.3 13.3 0.042 13.6 10.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF588) DUF4956 PF16316.5 EDK37730.2 - 0.36 10.5 6.8 5.5 6.6 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4956) Ank_2 PF12796.7 EDK37731.2 - 1.3e-58 195.5 1.4 7.6e-17 61.7 0.1 3.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK37731.2 - 3.5e-36 123.1 0.3 2e-11 44.2 0.1 5.4 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK37731.2 - 6.1e-33 112.5 0.8 1.1e-09 38.4 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK37731.2 - 7.6e-28 93.5 0.0 0.00076 19.8 0.0 6.5 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EDK37731.2 - 1e-23 82.7 2.6 0.00033 21.0 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat AnkUBD PF18418.1 EDK37731.2 - 0.067 13.3 0.0 1 9.6 0.0 2.7 2 1 1 3 3 3 0 Ankyrin ubiquitin-binding domain Sugar_tr PF00083.24 EDK37732.2 - 5.1e-120 401.4 26.9 6e-120 401.2 26.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37732.2 - 2.8e-13 49.5 34.8 2e-11 43.4 7.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Prenyltransf PF01255.19 EDK37733.2 - 0.0026 17.3 0.0 0.024 14.2 0.0 2.1 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase DUF5099 PF17025.5 EDK37733.2 - 0.022 15.1 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) DUF3284 PF11687.8 EDK37735.2 - 0.018 14.9 0.1 0.046 13.6 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3284) zf-met PF12874.7 EDK37735.2 - 1.7 9.1 5.0 9.3 6.8 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type IPPT PF01715.17 EDK37736.2 - 1e-60 205.4 0.0 1.2e-60 205.2 0.0 1.0 1 0 0 1 1 1 1 IPP transferase baeRF_family12 PF18856.1 EDK37736.2 - 0.084 13.5 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Arginase PF00491.21 EDK37736.2 - 0.088 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Arginase family baeRF_family3 PF18845.1 EDK37736.2 - 0.13 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 BRO1 PF03097.18 EDK37737.2 - 2.3e-92 309.8 2.9 2.3e-92 309.8 2.9 1.8 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDK37737.2 - 2.4e-61 207.6 8.9 2.4e-61 207.6 8.9 1.7 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV LisH_TPL PF17814.1 EDK37737.2 - 0.1 12.3 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 0 LisH-like dimerisation domain SF3A3 PF16837.5 EDK37737.2 - 0.23 12.0 6.0 0.42 11.2 0.1 3.7 4 1 0 4 4 4 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Myb_DNA-binding PF00249.31 EDK37738.2 - 8.1e-21 74.0 6.9 2e-10 40.7 1.0 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK37738.2 - 5.1e-20 71.5 1.3 3.8e-11 43.1 1.3 2.9 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EDK37738.2 - 0.0028 17.7 1.7 0.21 11.7 0.1 3.7 4 1 0 4 4 4 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain UME PF08064.13 EDK37739.2 - 0.0059 16.5 0.3 0.1 12.5 0.0 2.9 2 1 0 2 2 2 1 UME (NUC010) domain CAF20 PF17052.5 EDK37740.1 - 5.6e-60 202.1 2.0 6.4e-60 201.9 2.0 1.0 1 0 0 1 1 1 1 Cap associated factor Folliculin PF11704.8 EDK37740.1 - 0.022 14.6 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RRP7 PF12923.7 EDK37740.1 - 0.11 12.7 1.4 0.18 11.9 0.2 1.9 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Tma16 PF11176.8 EDK37741.2 - 7.4e-49 165.4 5.5 8.8e-49 165.1 5.5 1.0 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Antimicrobial_2 PF08023.12 EDK37741.2 - 0.082 13.4 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Frog antimicrobial peptide FMP23 PF17315.2 EDK37742.2 - 1.4e-13 51.3 9.8 0.0053 16.9 0.0 6.7 3 1 3 6 6 6 4 Found in mitochondrial proteome PAS_3 PF08447.12 EDK37742.2 - 0.0093 16.2 1.2 0.64 10.4 0.0 3.3 3 0 0 3 3 3 1 PAS fold Mating_N PF12731.7 EDK37742.2 - 0.029 14.5 1.5 0.14 12.2 0.1 2.9 2 0 0 2 2 2 0 Mating-type protein beta 1 RGS PF00615.19 EDK37743.2 - 4.9e-06 26.8 0.1 0.0027 17.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain NAT PF04768.13 EDK37745.2 - 1.3e-51 174.6 1.2 3.3e-51 173.3 0.5 2.0 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EDK37745.2 - 1e-31 109.9 0.0 2.4e-31 108.7 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EDK37745.2 - 3.2e-29 102.2 0.3 2.6e-28 99.3 0.0 2.1 2 0 0 2 2 2 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 EDK37745.2 - 1.8e-08 34.7 0.0 4.9e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 EDK37745.2 - 0.01 15.9 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Y_phosphatase2 PF03162.13 EDK37746.2 - 1.2e-30 106.3 0.2 2.8e-29 101.8 0.2 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family DdrB PF12747.7 EDK37746.2 - 0.21 11.4 0.9 0.48 10.2 0.2 1.9 2 1 0 2 2 2 0 DdrB-like protein Mso1_C PF14477.6 EDK37747.2 - 3.4e-30 104.2 17.0 3.4e-30 104.2 17.0 3.1 3 1 0 3 3 3 1 Membrane-polarising domain of Mso1 Mso1_Sec1_bdg PF14475.6 EDK37747.2 - 5.5e-18 64.3 0.1 1.2e-17 63.2 0.1 1.6 1 0 0 1 1 1 1 Sec1-binding region of Mso1 DEAD PF00270.29 EDK37748.2 - 1.4e-33 116.1 0.2 4.4e-33 114.5 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37748.2 - 2.1e-25 89.2 0.3 9e-25 87.2 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37748.2 - 2.5e-09 37.4 0.0 7.6e-09 35.8 0.0 1.8 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDK37748.2 - 0.072 12.8 0.7 0.12 12.0 0.7 1.3 1 0 0 1 1 1 0 AAA domain HIM1 PF08732.10 EDK37749.2 - 1.1e-07 31.6 0.0 1.6e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 HIM1 NAD_binding_10 PF13460.6 EDK37749.2 - 1.8e-06 28.0 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK37749.2 - 0.00062 19.3 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EDK37749.2 - 0.0043 17.5 0.0 0.0076 16.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 EDK37749.2 - 0.017 15.9 0.2 0.05 14.3 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sad1_UNC PF07738.13 EDK37750.2 - 2.2e-34 118.3 0.2 6e-34 116.9 0.2 1.8 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Muskelin_N PF06588.11 EDK37750.2 - 0.007 16.3 0.3 0.016 15.1 0.3 1.6 1 0 0 1 1 1 1 Muskelin N-terminus RAI1 PF08652.11 EDK37751.2 - 2.6e-27 94.8 0.0 5.6e-27 93.7 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Catalase PF00199.19 EDK37752.1 - 2.1e-191 636.1 1.1 2.9e-191 635.6 1.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDK37752.1 - 2.9e-13 49.8 0.7 4.3e-12 46.1 0.3 2.8 3 0 0 3 3 3 1 Catalase-related immune-responsive Macoilin PF09726.9 EDK37754.2 - 4.1 5.9 12.9 4.8 5.6 12.9 1.1 1 0 0 1 1 1 0 Macoilin family Torus PF16131.5 EDK37755.2 - 4.9e-37 127.0 0.1 1e-36 125.9 0.1 1.6 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 EDK37755.2 - 1.8e-06 27.6 0.1 3.4e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK37755.2 - 0.00041 20.3 0.1 0.00071 19.5 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif AKAP_110 PF05716.13 EDK37755.2 - 0.014 13.6 0.2 0.018 13.3 0.2 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) zf-CCCH_4 PF18044.1 EDK37755.2 - 0.039 13.8 8.0 0.075 12.9 8.0 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger PAPA-1 PF04795.12 EDK37755.2 - 0.042 14.6 1.4 0.076 13.8 1.4 1.3 1 0 0 1 1 1 0 PAPA-1-like conserved region DEAD PF00270.29 EDK37756.2 - 5.5e-43 146.8 0.1 1.4e-42 145.5 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37756.2 - 1.8e-30 105.5 0.5 5.8e-30 103.9 0.3 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37756.2 - 0.00012 22.1 0.0 0.00037 20.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDK37756.2 - 0.00038 19.8 0.0 0.00038 19.8 0.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Nodulin-like PF06813.13 EDK37757.2 - 0.00075 19.1 1.3 0.00075 19.1 1.3 2.4 2 1 0 2 2 2 2 Nodulin-like PUCC PF03209.15 EDK37757.2 - 0.0031 16.6 2.6 0.0031 16.6 2.6 1.6 2 0 0 2 2 2 1 PUCC protein Aminotran_3 PF00202.21 EDK37758.2 - 2.7e-66 223.9 0.0 3.3e-66 223.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EDK37758.2 - 0.0061 15.9 0.0 0.0091 15.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase NAC PF01849.18 EDK37759.1 - 2e-14 53.3 0.1 3.9e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 NAC domain Pyridoxal_deC PF00282.19 EDK37760.2 - 3.7e-55 187.2 0.0 5.4e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDK37760.2 - 1.4e-07 30.8 0.0 2.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF1774 PF08611.10 EDK37761.2 - 9.4e-30 102.8 2.6 9.4e-30 102.8 2.6 2.8 4 0 0 4 4 4 1 Fungal protein of unknown function (DUF1774) DUF4834 PF16118.5 EDK37761.2 - 0.078 13.9 1.6 14 6.7 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4083 PF13314.6 EDK37761.2 - 0.27 11.2 0.0 0.27 11.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) SF3b10 PF07189.11 EDK37762.1 - 8.7e-30 102.7 0.0 9.4e-30 102.6 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) GATA PF00320.27 EDK37763.2 - 2.4e-15 55.8 4.7 4.5e-15 55.0 4.7 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EDK37763.2 - 2.5e-06 27.2 0.0 5.3e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Elf1 PF05129.13 EDK37763.2 - 0.00061 19.8 0.2 0.0015 18.5 0.2 1.6 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like TF_Zn_Ribbon PF08271.12 EDK37763.2 - 0.0011 18.5 1.9 0.0014 18.1 0.5 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding ArfGap PF01412.18 EDK37763.2 - 0.031 14.3 0.4 0.059 13.4 0.1 1.8 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf DUF2197 PF09963.9 EDK37763.2 - 0.036 14.3 0.1 0.093 13.0 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) Zn-ribbon_8 PF09723.10 EDK37763.2 - 0.12 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Zinc ribbon domain ADH_zinc_N PF00107.26 EDK37764.2 - 2e-11 44.0 0.0 3.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDK37764.2 - 1.1e-06 29.8 0.0 2.7e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK37764.2 - 0.0035 17.2 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Peptidase_S66 PF02016.15 EDK37764.2 - 0.069 13.3 0.0 0.18 11.9 0.0 1.7 1 1 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Sel1 PF08238.12 EDK37765.2 - 8.5e-12 45.3 5.1 0.002 18.7 0.0 7.4 8 1 0 8 8 8 2 Sel1 repeat TPR_11 PF13414.6 EDK37765.2 - 0.0064 16.2 0.1 0.021 14.5 0.1 2.0 1 0 0 1 1 1 1 TPR repeat TPR_6 PF13174.6 EDK37765.2 - 0.068 13.8 1.8 28 5.6 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDK37765.2 - 0.074 13.5 0.0 0.32 11.5 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37765.2 - 0.079 13.8 0.0 13 7.0 0.0 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDK37765.2 - 0.098 13.0 0.0 1.9 8.8 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK37765.2 - 0.13 12.4 0.4 1.6 9.1 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Aa_trans PF01490.18 EDK37766.2 - 1.9e-82 277.1 36.4 2.3e-82 276.9 36.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ApoO PF09769.9 EDK37767.2 - 2e-28 98.9 0.3 3.2e-27 95.1 0.0 2.0 2 0 0 2 2 2 2 Apolipoprotein O ApbA_C PF08546.11 EDK37768.2 - 8.2e-08 32.5 0.0 1.8e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Tropomyosin_1 PF12718.7 EDK37768.2 - 0.011 15.9 13.8 0.017 15.3 13.8 1.3 1 0 0 1 1 1 0 Tropomyosin like Atg14 PF10186.9 EDK37768.2 - 0.014 14.5 10.3 0.027 13.6 10.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_F PF12259.8 EDK37768.2 - 0.031 12.8 4.0 0.045 12.3 4.0 1.1 1 0 0 1 1 1 0 Baculovirus F protein MethyltransfD12 PF02086.15 EDK37768.2 - 0.04 13.6 2.1 0.07 12.8 2.1 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Jnk-SapK_ap_N PF09744.9 EDK37768.2 - 0.094 12.9 13.8 0.23 11.6 13.8 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF2968 PF11180.8 EDK37768.2 - 0.18 11.4 9.1 0.35 10.5 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Spc7 PF08317.11 EDK37768.2 - 0.24 10.2 14.4 0.41 9.5 14.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 EDK37768.2 - 0.25 8.8 11.8 0.36 8.3 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-Q PF13094.6 EDK37768.2 - 0.28 11.4 14.2 0.91 9.7 14.1 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4407 PF14362.6 EDK37768.2 - 0.47 9.7 3.8 0.94 8.8 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3496 PF12001.8 EDK37768.2 - 0.97 9.8 9.6 0.22 11.9 5.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) CtIP_N PF10482.9 EDK37768.2 - 1.3 9.1 11.8 2.8 8.0 11.8 1.5 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Exonuc_VII_L PF02601.15 EDK37768.2 - 1.8 8.1 7.4 2.9 7.4 7.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EDK37768.2 - 2.3 6.1 8.1 3.3 5.5 8.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HemX PF04375.14 EDK37768.2 - 3 7.1 12.1 5.4 6.2 12.1 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fib_alpha PF08702.10 EDK37768.2 - 4.9 7.3 8.2 2.1 8.5 5.3 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Thymidylate_kin PF02223.17 EDK37769.2 - 4e-40 137.5 0.0 5e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase dNK PF01712.19 EDK37769.2 - 7.4e-07 29.2 0.0 1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EDK37769.2 - 0.00016 22.2 0.0 0.00024 21.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDK37769.2 - 0.00074 19.8 0.0 0.001 19.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDK37769.2 - 0.012 15.0 0.0 0.026 14.0 0.0 1.7 1 1 0 1 1 1 0 Chromatin associated protein KTI12 CPT PF07931.12 EDK37769.2 - 0.12 12.2 0.0 0.27 11.0 0.0 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 EDK37769.2 - 0.13 12.7 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Clat_adaptor_s PF01217.20 EDK37770.2 - 5.9e-51 172.2 2.6 6.8e-51 171.9 2.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ku PF02735.16 EDK37771.2 - 9e-28 97.4 0.0 1.5e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EDK37771.2 - 6.8e-17 61.9 0.1 1.7e-16 60.7 0.1 1.7 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EDK37771.2 - 5.1e-05 23.9 0.3 0.00013 22.6 0.3 1.7 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm MukF_C PF17193.4 EDK37771.2 - 0.066 13.4 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 MukF C-terminal domain Mannosyl_trans3 PF11051.8 EDK37772.2 - 2.1e-64 217.6 0.0 3.3e-64 216.9 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Mvb12 PF09452.10 EDK37773.2 - 0.002 18.5 0.3 0.0034 17.8 0.3 1.5 1 1 0 1 1 1 1 ESCRT-I subunit Mvb12 RNA_pol_Rpb8 PF03870.15 EDK37774.1 - 6.5e-46 156.0 0.1 7.3e-46 155.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EDK37774.1 - 6e-06 26.3 0.6 0.042 13.9 0.1 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G MFS_1 PF07690.16 EDK37775.2 - 2.6e-06 26.6 28.1 3.6e-06 26.2 25.4 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2023 PF09633.10 EDK37775.2 - 0.032 14.4 0.0 5.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2023) Cation_efflux PF01545.21 EDK37775.2 - 0.099 12.4 0.1 0.099 12.4 0.1 3.5 3 2 0 3 3 3 0 Cation efflux family DUF2462 PF09495.10 EDK37776.1 - 3.3e-17 63.0 11.0 3.3e-17 63.0 11.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) GATase_5 PF13507.6 EDK37777.2 - 6.6e-106 353.2 0.1 1e-105 352.5 0.1 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EDK37777.2 - 3.4e-39 134.5 0.3 1.7e-26 93.2 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EDK37777.2 - 5.6e-29 100.5 0.0 1.2e-28 99.4 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EDK37777.2 - 1.9e-22 79.5 0.0 6.5e-22 77.8 0.0 2.0 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain PMD PF10536.9 EDK37777.2 - 0.015 14.4 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Plant mobile domain nsp8 PF08717.10 EDK37777.2 - 0.17 11.8 0.0 0.44 10.4 0.0 1.6 1 0 0 1 1 1 0 nsp8 replicase Ribosomal_S3_C PF00189.20 EDK37778.1 - 5.6e-23 81.3 0.3 2.6e-22 79.2 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EDK37778.1 - 1.5e-08 34.3 0.4 2.8e-08 33.5 0.4 1.5 1 0 0 1 1 1 1 KH domain Tmemb_14 PF03647.13 EDK37780.1 - 5.8e-24 84.7 6.5 6.8e-24 84.4 6.5 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 EDK37780.1 - 0.022 15.0 2.4 0.064 13.6 2.4 1.8 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 19 ATPase_gene1 PF09527.10 EDK37780.1 - 0.44 10.7 5.3 1.9 8.7 0.1 2.3 2 1 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter SNF2_N PF00176.23 EDK37782.2 - 1.7e-66 224.4 0.9 3.2e-66 223.4 0.9 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EDK37782.2 - 3e-28 98.9 14.0 3e-28 98.9 14.0 2.6 2 0 0 2 2 2 1 DNA-binding domain Helicase_C PF00271.31 EDK37782.2 - 1.4e-17 64.0 0.0 7.9e-17 61.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37782.2 - 5.2e-07 29.8 1.1 2.1e-06 27.8 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK37782.2 - 0.00046 19.4 7.0 0.00051 19.3 0.0 3.2 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 baeRF_family12 PF18856.1 EDK37782.2 - 0.064 13.8 0.1 0.064 13.8 0.1 2.9 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 12 adh_short PF00106.25 EDK37783.2 - 8.1e-38 129.8 0.1 1e-37 129.5 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK37783.2 - 3.2e-35 121.8 0.0 3.6e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK37783.2 - 9.3e-15 55.0 0.0 1.1e-14 54.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK37783.2 - 3.6e-09 36.8 0.0 5e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EDK37783.2 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EDK37783.2 - 0.0076 15.7 0.0 0.022 14.2 0.0 1.8 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDK37783.2 - 0.0078 15.7 0.1 0.017 14.6 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Vezatin PF12632.7 EDK37784.2 - 1.8e-50 171.9 12.5 1.8e-50 171.9 12.5 2.2 2 1 0 2 2 2 1 Mysoin-binding motif of peroxisomes ZapB PF06005.12 EDK37784.2 - 0.79 10.2 4.9 9.3 6.8 0.1 3.2 3 0 0 3 3 3 0 Cell division protein ZapB CK2S PF15011.6 EDK37784.2 - 2.1 8.2 9.7 5.7 6.8 0.1 3.3 3 0 0 3 3 3 0 Casein Kinase 2 substrate F-box-like PF12937.7 EDK37786.2 - 0.0015 18.4 1.1 0.005 16.7 0.4 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDK37786.2 - 0.012 15.5 0.4 0.012 15.5 0.4 2.7 3 1 1 4 4 4 0 F-box domain GATA PF00320.27 EDK37787.2 - 6.1e-17 60.9 4.2 1.1e-16 60.1 4.2 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EDK37787.2 - 4.3e-10 39.2 1.4 8.4e-10 38.3 1.4 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Rdx PF10262.9 EDK37788.1 - 1.5e-22 79.6 0.0 2e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Rdx family zf-3CxxC PF13695.6 EDK37788.1 - 0.0027 18.2 0.0 0.0049 17.3 0.0 1.4 1 1 0 1 1 1 1 Zinc-binding domain Mucin15 PF15672.5 EDK37789.2 - 0.013 15.0 0.3 0.018 14.6 0.3 1.3 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Thioredoxin_2 PF13098.6 EDK37790.2 - 0.016 15.7 0.0 0.026 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Evr1_Alr PF04777.13 EDK37791.2 - 6.7e-32 109.9 1.7 8.9e-32 109.5 1.7 1.2 1 0 0 1 1 1 1 Erv1 / Alr family SNAD4 PF18750.1 EDK37791.2 - 0.084 13.0 0.1 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 HD_3 PF13023.6 EDK37792.1 - 4.2e-38 130.8 0.1 4.9e-38 130.6 0.1 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EDK37792.1 - 7.2e-08 32.4 0.3 1.2e-07 31.7 0.3 1.3 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EDK37792.1 - 1.1e-07 32.1 0.1 2e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 HD domain Ribosomal_L27A PF00828.19 EDK37793.1 - 1.4e-18 67.7 0.0 1.6e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Sugar_tr PF00083.24 EDK37794.2 - 1e-55 189.4 9.1 1.5e-55 188.8 9.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37794.2 - 5.2e-09 35.5 19.7 3.3e-08 32.8 20.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily PrgU PF09627.10 EDK37794.2 - 0.061 13.3 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 PrgU-like protein Sugar_tr PF00083.24 EDK37795.2 - 9.4e-34 117.0 9.9 1.1e-33 116.8 9.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK37795.2 - 2.8e-18 66.0 7.8 3e-18 65.9 7.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK37795.2 - 1.5e-07 31.0 7.5 2.2e-07 30.5 7.5 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_5 PF05631.14 EDK37795.2 - 3.7e-06 26.1 3.0 5.9e-06 25.4 2.8 1.3 1 1 0 1 1 1 1 Sugar-tranasporters, 12 TM TRI12 PF06609.13 EDK37795.2 - 0.00055 18.5 2.1 0.00068 18.2 2.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 EDK37795.2 - 0.0035 16.0 1.0 0.0046 15.6 1.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Zn_clus PF00172.18 EDK37796.2 - 1.1e-06 28.6 11.1 2.3e-06 27.6 11.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EDK37796.2 - 9.6e-05 22.4 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold tRNA_bind PF01588.20 EDK37797.2 - 1.7e-26 92.2 0.1 3.5e-26 91.1 0.1 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EDK37797.2 - 0.0027 17.7 0.2 0.0071 16.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain RNA_pol_Rpc4 PF05132.14 EDK37797.2 - 0.0095 16.4 5.1 0.019 15.4 5.1 1.7 1 0 0 1 1 1 1 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 EDK37797.2 - 0.02 14.7 10.7 0.039 13.8 10.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GST_C PF00043.25 EDK37797.2 - 0.023 14.9 0.1 0.023 14.9 0.1 2.7 2 2 0 2 2 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EDK37797.2 - 0.036 13.9 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Latrophilin PF02354.16 EDK37797.2 - 0.058 12.5 1.1 0.09 11.8 1.1 1.2 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region NARP1 PF12569.8 EDK37797.2 - 0.071 12.0 14.9 0.1 11.5 14.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TRAP_alpha PF03896.16 EDK37797.2 - 0.28 10.4 6.2 0.42 9.8 6.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 EDK37797.2 - 0.3 10.8 3.8 0.49 10.1 3.8 1.3 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 EDK37797.2 - 0.33 9.2 9.1 0.46 8.7 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EDK37797.2 - 0.42 9.4 9.2 0.64 8.7 9.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 EDK37797.2 - 0.69 8.6 4.9 0.82 8.4 4.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MCM_bind PF09739.9 EDK37797.2 - 0.94 7.8 8.2 1.3 7.4 8.2 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Gti1_Pac2 PF09729.9 EDK37797.2 - 1.1 9.3 6.9 3.5 7.7 7.1 1.7 2 0 0 2 2 2 0 Gti1/Pac2 family Presenilin PF01080.17 EDK37797.2 - 2.2 6.9 7.4 3 6.5 7.4 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 EDK37797.2 - 2.4 7.2 7.7 3.9 6.5 7.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Vfa1 PF08432.10 EDK37797.2 - 5.5 7.3 19.7 14 5.9 19.7 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 eRF1_1 PF03463.15 EDK37798.2 - 3.8e-38 130.4 0.3 7.2e-38 129.5 0.3 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EDK37798.2 - 1.5e-25 90.0 0.1 2.3e-25 89.4 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDK37798.2 - 5.2e-19 68.8 0.0 2.3e-18 66.7 0.0 2.1 2 0 0 2 2 2 1 eRF1 domain 3 Tim17 PF02466.19 EDK37799.1 - 0.013 15.8 5.6 0.031 14.7 5.5 1.8 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family AAA_15 PF13175.6 EDK37800.2 - 4.6e-17 62.8 30.5 4.9e-13 49.5 0.5 3.0 2 2 1 3 3 3 2 AAA ATPase domain SMC_N PF02463.19 EDK37800.2 - 9.7e-15 54.6 39.0 1.5e-13 50.7 39.0 3.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDK37800.2 - 9.1e-11 42.6 37.5 9.1e-11 42.6 37.5 5.8 2 2 1 3 3 1 1 AAA domain AAA_29 PF13555.6 EDK37800.2 - 7e-06 25.7 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EDK37800.2 - 0.00011 22.1 15.3 0.0022 17.8 0.4 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EDK37800.2 - 0.00087 19.7 5.1 0.0014 19.1 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Adeno_IVa2 PF02456.15 EDK37800.2 - 0.015 14.1 1.7 0.47 9.2 0.0 3.1 3 0 0 3 3 3 0 Adenovirus IVa2 protein AAA_33 PF13671.6 EDK37800.2 - 0.039 14.1 0.0 0.039 14.1 0.0 3.8 4 1 0 4 4 3 0 AAA domain RNA_helicase PF00910.22 EDK37800.2 - 0.085 13.3 1.1 0.29 11.5 0.1 2.6 2 0 0 2 2 2 0 RNA helicase RsgA_GTPase PF03193.16 EDK37800.2 - 0.15 12.0 0.0 0.15 12.0 0.0 3.5 3 0 0 3 3 3 0 RsgA GTPase DUF1599 PF07659.11 EDK37800.2 - 0.44 11.0 2.1 31 5.1 0.1 3.3 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 MMR_HSR1 PF01926.23 EDK37800.2 - 1 9.4 3.5 3.8 7.6 0.1 3.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase APC_N_CC PF16689.5 EDK37800.2 - 1.8 8.7 11.9 0.085 12.9 2.7 3.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain AAA_22 PF13401.6 EDK37800.2 - 2.8 8.2 8.0 0.8 10.0 0.2 3.8 3 1 0 3 3 3 0 AAA domain tRNA-synt_1c PF00749.21 EDK37801.2 - 7.1e-98 327.4 0.0 9.4e-98 327.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain MPM1 PF17234.2 EDK37802.2 - 1.4e-50 171.9 11.2 1.4e-50 171.9 11.2 2.3 2 0 0 2 2 2 1 Mitochondrial peculiar membrane protein 1 Vps55 PF04133.14 EDK37803.2 - 7.2e-42 142.1 3.9 8.6e-42 141.8 3.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 HlyIII PF03006.20 EDK37803.2 - 0.29 10.8 8.7 1.8 8.3 8.7 1.9 1 1 0 1 1 1 0 Haemolysin-III related DUF4018 PF13210.6 EDK37803.2 - 3.4 7.4 9.0 3.2 7.5 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4018) SNARE PF05739.19 EDK37804.2 - 2.1e-07 30.8 1.7 5.8e-07 29.4 1.7 1.8 1 0 0 1 1 1 1 SNARE domain Marek_A PF02124.15 EDK37804.2 - 0.05 13.4 0.4 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Marek's disease glycoprotein A Uso1_p115_C PF04871.13 EDK37804.2 - 0.061 13.7 1.6 0.25 11.7 0.1 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 EDK37804.2 - 0.084 12.2 1.9 0.71 9.2 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Lysine_decarbox PF03641.14 EDK37805.1 - 1.9e-42 144.5 0.0 2.5e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EDK37805.1 - 8.7e-15 54.6 0.8 1.7e-14 53.7 0.8 1.6 1 1 0 1 1 1 1 SLOG cluster4 family Pro_CA PF00484.19 EDK37806.2 - 9.4e-41 139.7 0.0 1.3e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase SNF2_N PF00176.23 EDK37807.2 - 1.2e-64 218.3 1.8 4.8e-64 216.3 1.8 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK37807.2 - 3.8e-22 78.7 0.0 1.3e-21 77.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37807.2 - 1.9e-09 37.8 0.1 2e-08 34.4 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK37807.2 - 1.2e-06 28.4 0.0 3.1e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EDK37807.2 - 0.015 15.0 0.0 0.061 13.0 0.0 2.1 1 1 0 1 1 1 0 SWI2/SNF2 ATPase DUF22 PF01629.16 EDK37807.2 - 0.063 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF22 Glyco_hydro_15 PF00723.21 EDK37808.2 - 3.6e-50 171.1 0.0 4.3e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 MMgT PF10270.9 EDK37809.2 - 8.5e-25 87.0 0.2 9.9e-25 86.8 0.2 1.0 1 0 0 1 1 1 1 Membrane magnesium transporter FA_hydroxylase PF04116.13 EDK37810.2 - 8.2e-24 84.4 22.7 8.2e-24 84.4 22.7 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily MFS_1 PF07690.16 EDK37811.2 - 1.6e-41 142.5 33.3 4.8e-41 140.8 32.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short_C2 PF13561.6 EDK37812.1 - 5e-52 176.8 0.1 1.3e-51 175.4 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK37812.1 - 5.4e-38 130.4 0.2 1.5e-37 128.9 0.2 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK37812.1 - 1e-06 28.8 0.1 1.5e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK37812.1 - 0.011 15.2 0.2 0.035 13.5 0.2 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDK37812.1 - 0.018 14.5 0.1 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EDK37812.1 - 0.089 11.9 0.0 0.25 10.4 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain CbiA PF01656.23 EDK37812.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_M3 PF01432.20 EDK37813.2 - 7e-102 342.0 0.1 8.5e-102 341.8 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 EDK37813.2 - 0.045 13.4 0.2 0.073 12.7 0.2 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Peptidase_M3 PF01432.20 EDK37814.2 - 1.2e-30 107.2 3.7 1.2e-30 107.2 3.7 1.4 2 0 0 2 2 2 1 Peptidase family M3 Peptidase_M48_N PF16491.5 EDK37814.2 - 0.049 13.5 0.2 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices Gtr1_RagA PF04670.12 EDK37815.2 - 4.1e-69 232.5 0.1 5.3e-69 232.1 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EDK37815.2 - 0.00065 19.2 0.0 0.0019 17.7 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.6 EDK37815.2 - 0.028 14.4 0.0 0.063 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EDK37815.2 - 0.12 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit tRNA-synt_2 PF00152.20 EDK37816.2 - 6.6e-77 258.7 0.1 8e-77 258.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDK37816.2 - 7.6e-05 22.6 0.1 0.00017 21.5 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TYW3 PF02676.14 EDK37817.2 - 4.6e-67 225.5 0.0 7e-67 224.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase TYW3 Fer4_24 PF18109.1 EDK37817.2 - 0.12 12.7 0.2 0.42 10.9 0.2 1.9 1 0 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain DUF4252 PF14060.6 EDK37817.2 - 0.2 11.6 0.9 0.26 11.2 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) GRIP PF01465.20 EDK37818.2 - 8.4e-15 54.4 0.1 3.2e-14 52.6 0.1 2.1 1 0 0 1 1 1 1 GRIP domain TPR_MLP1_2 PF07926.12 EDK37818.2 - 3.2e-05 24.0 20.6 3.2e-05 24.0 20.6 10.8 5 3 6 11 11 10 5 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EDK37818.2 - 0.00056 20.4 26.3 0.00056 20.4 26.3 9.5 3 1 5 9 9 9 4 Apg6 coiled-coil region CEP63 PF17045.5 EDK37818.2 - 0.0015 18.5 14.7 0.0015 18.5 14.7 7.8 2 2 5 7 7 6 2 Centrosomal protein of 63 kDa Golgin_A5 PF09787.9 EDK37818.2 - 0.0019 17.7 20.0 0.0019 17.7 20.0 7.4 2 1 6 8 8 8 2 Golgin subfamily A member 5 Spc7 PF08317.11 EDK37818.2 - 0.0022 16.9 45.7 0.0032 16.4 17.1 8.3 2 1 7 9 9 8 5 Spc7 kinetochore protein ATG16 PF08614.11 EDK37818.2 - 0.0046 17.2 17.7 0.0046 17.2 17.7 9.5 2 1 7 9 9 8 3 Autophagy protein 16 (ATG16) Rootletin PF15035.6 EDK37818.2 - 0.0049 16.9 22.0 0.0049 16.9 22.0 7.9 2 2 6 8 8 7 3 Ciliary rootlet component, centrosome cohesion DUF5082 PF16888.5 EDK37818.2 - 0.0073 16.6 13.8 0.0073 16.6 13.8 9.5 2 1 6 9 9 9 4 Domain of unknown function (DUF5082) PKcGMP_CC PF16808.5 EDK37818.2 - 2 8.3 44.3 0.15 12.0 6.9 10.2 7 2 2 9 9 9 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1664 PF07889.12 EDK37818.2 - 4 7.5 85.6 0.068 13.2 5.0 9.2 4 2 7 12 12 11 0 Protein of unknown function (DUF1664) WXG100 PF06013.12 EDK37818.2 - 7.1 6.9 46.1 0.21 11.9 2.6 9.1 6 4 2 8 8 8 0 Proteins of 100 residues with WXG DUF5053 PF16476.5 EDK37818.2 - 8.8 6.1 7.7 3 7.6 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF5053) RasGEF PF00617.19 EDK37819.2 - 1e-56 192.0 3.0 2.1e-56 190.9 1.2 2.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EDK37819.2 - 1.2e-22 80.1 1.9 3.7e-22 78.5 0.4 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 EDK37819.2 - 2.8e-15 55.6 0.0 7.8e-15 54.2 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK37819.2 - 9.3e-10 38.2 0.1 1.9e-09 37.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK37819.2 - 4.6e-06 26.2 0.0 1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Vps26 PF03643.15 EDK37820.2 - 4.5e-114 380.1 0.3 5.1e-114 379.9 0.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EDK37820.2 - 1.8e-07 31.4 1.3 0.015 15.4 0.1 2.4 1 1 1 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Mito_carr PF00153.27 EDK37821.2 - 4.3e-11 42.6 3.4 5.3e-07 29.5 0.3 3.4 3 1 0 3 3 3 2 Mitochondrial carrier protein BacA PF02673.18 EDK37821.2 - 0.013 15.3 0.1 0.72 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacitracin resistance protein BacA OMPdecase PF00215.24 EDK37822.2 - 3.7e-77 258.9 0.0 4.3e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Sec7 PF01369.20 EDK37823.2 - 9.7e-64 214.4 1.3 1.9e-63 213.4 0.1 2.0 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EDK37823.2 - 8e-14 51.8 2.0 8e-14 51.8 2.0 3.6 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EDK37823.2 - 5.3e-09 36.0 5.6 5.3e-09 36.0 5.6 3.8 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 SQS_PSY PF00494.19 EDK37824.1 - 1.5e-26 93.5 0.0 1.9e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF1706 PF08020.11 EDK37824.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) COPIIcoated_ERV PF07970.12 EDK37824.1 - 0.088 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter Pro_isomerase PF00160.21 EDK37825.2 - 9.6e-24 84.4 1.3 8.9e-23 81.3 1.3 2.1 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EDK37825.2 - 3.9e-10 39.1 1.7 8.9e-06 25.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK37825.2 - 1.6e-06 27.7 3.4 1e-05 25.1 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK37825.2 - 0.0007 19.8 0.2 0.015 15.6 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDK37825.2 - 0.00083 19.4 0.1 0.00083 19.4 0.1 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDK37825.2 - 0.013 15.1 2.0 0.07 12.8 0.2 2.9 2 2 2 4 4 4 0 TPR repeat TPR_16 PF13432.6 EDK37825.2 - 0.033 14.9 0.3 0.14 12.8 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDK37825.2 - 0.071 14.0 0.0 0.29 12.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDK37825.2 - 0.087 13.0 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_2 PF13639.6 EDK37826.2 - 2.8e-11 43.6 5.7 2.1e-10 40.8 1.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EDK37826.2 - 2.4e-08 34.2 0.3 2.4e-08 34.2 0.3 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EDK37826.2 - 1.6e-07 31.0 2.9 1.7e-07 31.0 0.4 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDK37826.2 - 3.2e-07 30.1 3.6 6.5e-06 25.9 1.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK37826.2 - 7.6e-07 28.9 4.8 6.1e-06 26.0 0.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK37826.2 - 1.2e-06 28.5 4.0 2e-05 24.5 0.5 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDK37826.2 - 1.6e-06 27.8 2.8 7.6e-06 25.7 0.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK37826.2 - 0.00011 22.1 5.9 0.00055 19.8 0.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDK37826.2 - 0.00023 21.3 0.9 0.00023 21.3 0.9 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EDK37826.2 - 0.00075 19.5 0.4 0.0029 17.6 0.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 EDK37826.2 - 0.015 15.5 0.0 0.045 13.9 0.0 1.8 1 0 0 1 1 1 0 U-box domain Zn_ribbon_17 PF17120.5 EDK37826.2 - 0.018 14.7 0.4 0.034 13.8 0.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EDK37826.2 - 0.058 13.2 2.8 0.082 12.7 0.3 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDK37826.2 - 0.072 13.3 5.3 0.12 12.5 1.2 2.9 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 EDK37826.2 - 0.14 11.9 3.4 7.4 6.4 0.3 2.6 2 0 0 2 2 2 0 RING-like zinc finger Rtf2 PF04641.12 EDK37826.2 - 0.3 10.4 0.0 0.3 10.4 0.0 3.5 3 1 0 3 3 3 0 Rtf2 RING-finger Asp PF00026.23 EDK37827.2 - 8.1e-61 206.1 8.0 1.7e-60 205.1 8.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK37827.2 - 2.4e-10 40.9 1.4 4.4e-09 36.8 0.8 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDK37827.2 - 5.5e-06 26.9 0.1 3.9 8.2 0.0 3.5 3 0 0 3 3 3 3 Aspartyl protease gag-asp_proteas PF13975.6 EDK37827.2 - 6e-05 23.5 0.0 7.2 7.2 0.0 3.5 3 0 0 3 3 3 3 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDK37827.2 - 0.0012 18.7 0.0 0.033 14.0 0.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Zn_clus PF00172.18 EDK37829.2 - 6.3e-05 23.0 9.9 0.00012 22.2 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Complex1_30kDa PF00329.19 EDK37830.1 - 1.1e-44 152.0 0.0 1.5e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit End3 PF12761.7 EDK37831.2 - 1.1e-62 211.8 7.6 1.6e-62 211.3 7.6 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EDK37831.2 - 4.1e-56 187.3 0.1 2.9e-54 181.4 0.2 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EDK37831.2 - 1.9e-05 23.9 1.3 6e-05 22.3 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EDK37831.2 - 0.00028 21.3 0.3 0.0019 18.6 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair DUF812 PF05667.11 EDK37831.2 - 0.0024 16.9 5.6 0.0028 16.6 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) PP_kinase_N PF13089.6 EDK37831.2 - 0.049 13.9 1.8 0.21 11.9 0.0 2.4 2 1 0 2 2 2 0 Polyphosphate kinase N-terminal domain EF-hand_8 PF13833.6 EDK37831.2 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EDK37831.2 - 0.13 12.3 0.7 0.36 10.9 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain Fib_alpha PF08702.10 EDK37831.2 - 0.54 10.4 7.8 0.94 9.7 7.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Ribosomal_S13 PF00416.22 EDK37832.2 - 3.3e-12 46.9 0.2 4.7e-12 46.4 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S13/S18 EOS1 PF12326.8 EDK37833.2 - 3e-45 154.3 14.9 2.2e-35 122.1 9.3 2.4 1 1 1 2 2 2 2 N-glycosylation protein Myb_DNA-bind_3 PF12776.7 EDK37835.1 - 0.00075 20.4 0.5 0.0014 19.6 0.4 1.5 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain Vac14_Fig4_bd PF11916.8 EDK37836.2 - 8.4e-69 230.8 11.6 1.9e-68 229.7 11.6 1.6 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EDK37836.2 - 2.1e-35 121.2 1.9 5.2e-35 119.9 0.5 2.6 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EDK37836.2 - 3.6e-05 23.6 1.5 0.027 14.7 0.0 5.3 6 0 0 6 6 6 1 HEAT repeat DUF3385 PF11865.8 EDK37836.2 - 4.9e-05 23.3 5.2 0.14 12.0 0.1 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 EDK37836.2 - 0.002 18.6 0.0 0.28 11.7 0.0 3.4 2 1 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.6 EDK37836.2 - 0.0028 18.0 0.0 0.47 10.9 0.0 4.2 4 1 0 4 4 4 1 HEAT repeats Cnd1 PF12717.7 EDK37836.2 - 0.0028 17.7 14.2 0.021 14.9 0.1 4.4 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF4996 PF16387.5 EDK37836.2 - 0.16 12.4 0.2 0.91 10.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DnaJ_C PF01556.18 EDK37837.2 - 1.1e-24 87.2 0.0 3.4e-24 85.6 0.0 1.7 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDK37837.2 - 5.4e-24 84.1 3.7 8.6e-24 83.4 3.7 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDK37837.2 - 3e-10 40.3 17.1 4.9e-10 39.6 17.1 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDK37837.2 - 0.0012 18.8 9.0 0.022 14.7 1.2 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein TackOD1 PF18551.1 EDK37837.2 - 2.7 7.6 8.7 13 5.4 1.8 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 HypA PF01155.19 EDK37837.2 - 6 6.9 10.5 15 5.6 2.7 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_2 PF12756.7 EDK37838.2 - 5.9e-31 106.8 11.1 2.7e-29 101.5 1.0 3.5 3 1 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_12 PF18658.1 EDK37838.2 - 0.0094 15.5 3.1 0.031 13.8 0.0 3.0 3 0 0 3 3 3 1 Zinc-finger C2H2-type zf-C2H2 PF00096.26 EDK37838.2 - 0.038 14.5 0.6 0.038 14.5 0.6 3.6 3 1 0 3 3 3 0 Zinc finger, C2H2 type Actin_micro PF17003.5 EDK37838.2 - 0.042 13.0 3.7 4.8 6.3 0.1 2.8 2 1 0 2 2 2 0 Putative actin-like family zf-C2H2_jaz PF12171.8 EDK37838.2 - 0.043 14.1 0.3 0.043 14.1 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 EDK37838.2 - 0.05 13.8 4.0 3.7 7.8 0.2 2.8 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Ribosomal_L24e PF01246.20 EDK37838.2 - 0.07 13.4 1.0 0.19 12.0 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein L24e zf-C2HE PF16278.5 EDK37838.2 - 0.35 11.3 2.6 12 6.4 0.1 3.5 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF629 PF04780.12 EDK37838.2 - 0.39 9.2 5.7 0.19 10.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF629) Zap1_zf2 PF18217.1 EDK37838.2 - 1.6 8.8 4.0 7.9 6.6 0.0 3.5 3 0 0 3 3 3 0 Zap1 zinc finger 2 zf-C2H2_4 PF13894.6 EDK37838.2 - 9.9 7.3 13.0 2.2 9.4 0.2 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger RIBIOP_C PF04950.12 EDK37839.2 - 3.6e-102 341.7 0.2 7.9e-102 340.6 0.0 1.7 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDK37839.2 - 5.2e-19 68.1 0.1 2.6e-18 65.9 0.0 2.3 3 0 0 3 3 3 1 AARP2CN (NUC121) domain PhzC-PhzF PF02567.16 EDK37839.2 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein Drc1-Sld2 PF11719.8 EDK37839.2 - 2.2 7.8 12.4 4.4 6.8 12.4 1.4 1 0 0 1 1 1 0 DNA replication and checkpoint protein Ribosomal_S14 PF00253.21 EDK37840.1 - 1.7e-16 59.7 3.3 1.8e-16 59.6 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Prim_Zn_Ribbon PF08273.12 EDK37840.1 - 0.046 14.0 1.8 2.4 8.5 0.3 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase RTP1_C1 PF10363.9 EDK37841.2 - 0.01 16.0 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EDK37841.2 - 0.042 13.9 2.6 1.2 9.3 0.0 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Flocculin_t3 PF13928.6 EDK37842.1 - 0.04 14.4 16.6 0.04 14.4 16.6 3.8 3 2 1 4 4 4 0 Flocculin type 3 repeat Putative_PNPOx PF01243.20 EDK37842.1 - 0.09 13.0 0.2 0.09 13.0 0.2 2.1 2 1 1 3 3 3 0 Pyridoxamine 5'-phosphate oxidase Flocculin_t3 PF13928.6 EDK37843.2 - 2.9e-05 24.5 29.1 0.02 15.4 19.1 2.7 2 1 0 2 2 2 2 Flocculin type 3 repeat Peptidase_S64 PF08192.11 EDK37845.2 - 1.8e-236 787.0 13.1 3.8e-229 762.8 0.2 2.0 1 1 1 2 2 2 2 Peptidase family S64 6PF2K PF01591.18 EDK37846.2 - 7.3e-86 287.1 0.5 1.2e-85 286.4 0.5 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDK37846.2 - 1.8e-36 125.7 0.0 2.4e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDK37846.2 - 4.2e-05 23.7 0.0 8.1e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDK37846.2 - 0.0048 16.4 0.0 0.0083 15.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 EDK37846.2 - 0.07 13.6 0.0 0.74 10.2 0.0 2.5 2 1 1 3 3 3 0 AAA domain UQ_con PF00179.26 EDK37847.1 - 1.5e-45 154.3 0.1 1.7e-45 154.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDK37847.1 - 0.0033 17.1 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDK37847.1 - 0.0052 17.1 0.8 0.0093 16.3 0.8 1.7 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 EDK37847.1 - 0.027 14.3 0.9 0.077 12.9 0.9 1.7 1 1 0 1 1 1 0 UEV domain Pex19 PF04614.12 EDK37848.2 - 6.9e-62 209.4 11.5 1.6e-61 208.2 10.3 2.1 2 1 0 2 2 2 1 Pex19 protein family Retrotran_gag_2 PF14223.6 EDK37848.2 - 0.038 13.6 2.5 0.071 12.8 1.1 2.1 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF445 PF04286.12 EDK37848.2 - 0.12 12.2 5.5 0.71 9.6 5.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Z1 PF10593.9 EDK37848.2 - 0.58 9.6 7.6 3 7.3 0.3 2.1 1 1 1 2 2 2 0 Z1 domain DUF2624 PF11116.8 EDK37848.2 - 1.8 9.5 5.2 4.9 8.1 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2624) GET2 PF08690.10 EDK37848.2 - 3 7.4 13.5 0.53 9.9 8.6 2.0 1 1 1 2 2 2 0 GET complex subunit GET2 Phage_TAC_12 PF12363.8 EDK37848.2 - 3.3 8.1 7.3 16 5.9 0.0 3.6 3 1 1 4 4 4 0 Phage tail assembly chaperone protein, TAC Lipoprotein_7 PF01540.16 EDK37848.2 - 9.9 5.3 12.6 0.76 9.0 5.7 2.4 3 0 0 3 3 3 0 Adhesin lipoprotein AAA PF00004.29 EDK37849.2 - 3.7e-91 302.4 0.0 1.4e-44 151.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK37849.2 - 2.7e-23 81.5 0.9 1.3e-10 40.9 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDK37849.2 - 2e-12 47.8 0.2 4.5e-06 27.2 0.0 3.8 2 2 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 EDK37849.2 - 3.2e-12 46.5 0.0 1.4e-05 24.9 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDK37849.2 - 1.5e-10 41.2 0.1 0.00087 19.3 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK37849.2 - 2.1e-08 34.5 0.9 0.0012 19.1 0.0 4.2 2 2 2 4 4 4 1 AAA domain AAA_2 PF07724.14 EDK37849.2 - 2.3e-08 34.4 0.0 0.0036 17.4 0.0 3.0 2 2 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDK37849.2 - 3.2e-08 33.9 0.0 0.0014 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EDK37849.2 - 9.3e-08 32.2 0.0 0.00046 20.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDK37849.2 - 7.4e-07 28.7 0.0 0.021 14.1 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EDK37849.2 - 6.4e-06 26.5 0.0 0.089 13.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 EDK37849.2 - 1.2e-05 25.3 0.1 0.023 14.6 0.1 3.4 2 2 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 EDK37849.2 - 3.1e-05 23.6 0.0 0.092 12.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDK37849.2 - 4.1e-05 23.1 0.1 0.14 11.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EDK37849.2 - 6.2e-05 23.0 0.0 0.046 13.7 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EDK37849.2 - 6.5e-05 23.2 0.0 0.16 12.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EDK37849.2 - 6.7e-05 22.8 0.0 0.0095 15.8 0.0 2.8 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_3 PF07726.11 EDK37849.2 - 7.7e-05 22.6 0.0 0.43 10.4 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDK37849.2 - 0.00038 20.4 0.0 0.012 15.6 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_11 PF13086.6 EDK37849.2 - 0.00039 20.3 0.0 0.051 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDK37849.2 - 0.00082 19.0 3.7 1.2 8.7 0.0 4.1 2 2 1 3 3 3 1 AAA domain DUF815 PF05673.13 EDK37849.2 - 0.0021 17.3 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 EDK37849.2 - 0.0031 17.3 0.6 0.059 13.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EDK37849.2 - 0.0043 16.8 0.0 2.5 7.8 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein ABC_tran PF00005.27 EDK37849.2 - 0.0053 17.3 0.0 0.41 11.2 0.0 2.9 2 0 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.18 EDK37849.2 - 0.0068 16.2 0.0 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EDK37849.2 - 0.009 16.6 0.0 1.2 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDK37849.2 - 0.016 14.5 0.2 4.2 6.6 0.0 3.0 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.6 EDK37849.2 - 0.022 14.5 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EDK37849.2 - 0.025 14.7 0.0 2.1 8.5 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 EDK37849.2 - 0.038 13.7 0.0 8.8 6.0 0.0 3.6 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_19 PF13245.6 EDK37849.2 - 0.038 14.3 0.8 0.49 10.7 0.0 2.7 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EDK37849.2 - 0.051 12.9 0.2 2.8 7.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EDK37849.2 - 0.063 13.2 0.2 0.73 9.7 0.0 2.9 3 2 2 5 5 4 0 NTPase AFG1_ATPase PF03969.16 EDK37849.2 - 0.075 11.9 0.3 0.27 10.1 0.0 1.9 3 0 0 3 3 3 0 AFG1-like ATPase ATPase_2 PF01637.18 EDK37849.2 - 0.08 12.8 0.0 6.8 6.5 0.0 3.2 2 2 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EDK37849.2 - 0.19 10.9 0.0 1 8.5 0.0 2.2 3 0 0 3 3 3 0 NB-ARC domain DSHCT PF08148.12 EDK37851.2 - 4.2e-49 166.4 0.1 1.1e-48 165.0 0.1 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EDK37851.2 - 2.9e-37 127.5 0.2 1.8e-36 124.9 0.3 2.1 2 0 0 2 2 2 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EDK37851.2 - 1.2e-23 84.4 6.7 1.4e-23 84.2 3.0 2.5 2 0 0 2 2 2 1 rRNA-processing arch domain DEAD PF00270.29 EDK37851.2 - 2.8e-20 72.8 0.3 8.2e-20 71.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK37851.2 - 3e-06 27.6 0.0 1.5e-05 25.3 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK37851.2 - 1.2e-05 25.3 0.6 4.2e-05 23.6 0.0 2.1 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit PP2C PF00481.21 EDK37852.2 - 3.1e-44 151.6 0.0 4.7e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Ribosomal_S10 PF00338.22 EDK37853.1 - 4.9e-26 90.8 0.8 6.6e-26 90.4 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ATP-synt_10 PF05176.14 EDK37854.2 - 1.4e-92 309.6 0.1 1.6e-92 309.4 0.1 1.0 1 0 0 1 1 1 1 ATP10 protein DCP2 PF05026.13 EDK37855.2 - 8.5e-26 90.1 0.0 1.8e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EDK37855.2 - 9.7e-10 38.6 0.0 3.3e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain RIO1 PF01163.22 EDK37857.2 - 7.5e-41 139.8 1.0 3e-40 137.8 1.0 2.0 1 1 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EDK37857.2 - 2.9e-34 117.1 0.3 3.8e-33 113.6 0.1 2.7 3 0 0 3 3 3 1 Rio2, N-terminal APH PF01636.23 EDK37857.2 - 1.3e-07 31.8 0.0 0.0011 19.0 0.0 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDK37857.2 - 0.00074 18.9 0.0 0.013 14.9 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDK37857.2 - 0.1 12.0 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain HSP70 PF00012.20 EDK37858.1 - 3.5e-231 768.6 10.8 4.2e-231 768.3 10.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDK37858.1 - 3.5e-17 62.2 1.4 6.9e-16 58.0 0.7 2.1 2 0 0 2 2 2 1 MreB/Mbl protein ATP-synt_DE PF00401.20 EDK37858.1 - 0.00017 21.8 4.9 0.00068 19.8 1.9 2.8 2 0 0 2 2 2 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain FGGY_C PF02782.16 EDK37858.1 - 0.00067 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDK37858.1 - 0.2 12.1 8.2 5 7.6 0.3 3.7 3 2 0 3 3 3 0 Cell division protein FtsA Y_phosphatase PF00102.27 EDK37859.2 - 2.7e-55 187.5 0.6 3.7e-55 187.0 0.6 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDK37859.2 - 0.011 15.8 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EDK37859.2 - 0.033 14.2 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family pPIWI_RE_X PF13111.6 EDK37859.2 - 0.097 11.9 0.3 0.15 11.2 0.3 1.4 1 0 0 1 1 1 0 pPIWI_RE module N-terminal domain DSPc PF00782.20 EDK37859.2 - 0.15 11.9 0.4 0.4 10.5 0.4 1.7 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain NMT1 PF09084.11 EDK37860.2 - 1e-15 58.3 0.0 2e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EDK37860.2 - 0.00018 21.3 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 EDK37860.2 - 0.00052 19.5 0.0 0.001 18.6 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.20 EDK37860.2 - 0.033 13.6 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain VitK2_biosynth PF02621.14 EDK37860.2 - 0.13 11.8 0.0 0.37 10.3 0.0 1.7 2 1 0 2 2 2 0 Menaquinone biosynthesis Ras PF00071.22 EDK37861.2 - 3.6e-59 199.0 0.0 4.1e-59 198.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37861.2 - 1.4e-34 118.8 0.0 1.9e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37861.2 - 8.4e-14 51.4 0.0 1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK37861.2 - 8.2e-07 28.6 0.0 1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK37861.2 - 3e-05 24.0 0.0 4.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37861.2 - 0.00018 21.5 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK37861.2 - 0.00027 21.4 0.0 0.00042 20.7 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 EDK37861.2 - 0.00044 19.8 0.0 0.00075 19.1 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain N2227 PF07942.12 EDK37862.2 - 1.4e-87 293.4 0.0 1.8e-87 293.0 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EDK37862.2 - 0.0022 17.8 0.0 0.0095 15.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK37862.2 - 0.03 15.1 0.0 0.4 11.4 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EDK37862.2 - 0.047 14.3 0.0 4.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 EDK37862.2 - 0.11 13.2 0.0 23 5.8 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Zn_clus PF00172.18 EDK37863.2 - 3.2e-07 30.4 8.0 5.3e-07 29.6 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lig_chan-Glu_bd PF10613.9 EDK37863.2 - 0.13 12.4 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Ligated ion channel L-glutamate- and glycine-binding site Zn_clus PF00172.18 EDK37865.2 - 2.8e-07 30.6 8.0 5.4e-07 29.6 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MutL_C PF08676.11 EDK37866.2 - 2.9e-24 85.5 0.0 5.7e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EDK37866.2 - 7.4e-20 70.8 0.1 7.4e-20 70.8 0.1 2.3 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDK37866.2 - 3.4e-11 43.1 0.0 1.4e-10 41.1 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDK37866.2 - 8.8e-07 29.4 1.3 9.9e-06 26.0 0.1 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HORMA PF02301.18 EDK37867.2 - 3.2e-15 56.3 0.2 4e-15 56.0 0.2 1.1 1 0 0 1 1 1 1 HORMA domain MENTAL PF10457.9 EDK37867.2 - 0.01 15.7 0.1 0.019 14.8 0.1 1.4 1 0 0 1 1 1 0 Cholesterol-capturing domain Ins134_P3_kin_N PF17927.1 EDK37867.2 - 0.079 13.4 0.1 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Mito_carr PF00153.27 EDK37868.2 - 1e-64 214.5 2.8 2.5e-21 75.4 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EDK37868.2 - 2.1e-21 76.1 16.7 5.7e-12 45.9 4.1 3.6 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 EDK37868.2 - 3.1e-20 70.1 15.6 6.7e-05 22.2 0.7 5.0 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EDK37868.2 - 4e-18 63.7 17.0 0.00027 20.6 0.2 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EDK37868.2 - 3.7e-16 58.7 13.0 3.5e-05 23.6 0.4 5.0 4 2 2 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 EDK37868.2 - 3.3e-11 42.2 12.2 0.00022 20.6 0.1 4.7 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EDK37868.2 - 0.00089 19.6 3.3 0.75 10.1 0.5 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 EDK37868.2 - 0.0061 16.7 1.2 0.39 10.9 0.1 3.0 1 1 3 4 4 4 1 p25-alpha EF-hand_9 PF14658.6 EDK37868.2 - 0.02 15.2 1.7 0.78 10.1 0.2 2.8 2 1 0 2 2 2 0 EF-hand domain Cpn60_TCP1 PF00118.24 EDK37869.2 - 1.8e-144 482.1 13.2 2e-144 481.9 13.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ldl_recept_b PF00058.17 EDK37869.2 - 0.11 13.0 0.0 0.58 10.7 0.0 2.3 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B DUF5442 PF17514.2 EDK37869.2 - 0.12 12.6 0.4 0.28 11.4 0.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) DUF5598 PF18127.1 EDK37870.2 - 9.4 6.7 5.4 53 4.4 0.4 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5598) AMPK1_CBM PF16561.5 EDK37872.1 - 6.6e-31 106.4 0.4 1.2e-30 105.5 0.4 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EDK37872.1 - 4.5e-28 97.3 1.6 4.5e-28 97.3 1.6 2.0 3 0 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interaction domain Alkyl_sulf_C PF14864.6 EDK37872.1 - 0.11 12.7 0.1 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal STE2 PF02116.15 EDK37873.2 - 1.1e-71 241.5 28.2 1.3e-71 241.2 28.2 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR ICE2 PF08426.10 EDK37874.2 - 2.3e-150 501.2 22.5 3.6e-150 500.6 22.5 1.3 1 1 0 1 1 1 1 ICE2 UTP25 PF06862.12 EDK37875.2 - 3.7e-202 672.3 9.6 4.8e-202 671.9 9.6 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EDK37875.2 - 0.051 13.3 0.1 0.71 9.6 0.1 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase Ribosomal_L35p PF01632.19 EDK37875.2 - 0.11 13.0 1.1 0.35 11.4 1.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L35 Y_phosphatase2 PF03162.13 EDK37876.2 - 9.1e-58 194.5 0.0 1.6e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDK37876.2 - 3.1e-07 30.6 0.0 4.3e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDK37876.2 - 0.0015 18.1 0.0 0.0037 16.8 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDK37876.2 - 0.0044 16.8 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Aim19 PF10315.9 EDK37877.2 - 1.4e-41 141.4 2.1 1.6e-41 141.2 2.1 1.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Histone PF00125.24 EDK37878.1 - 5.3e-51 172.4 2.8 5.9e-51 172.2 2.8 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDK37878.1 - 3.8e-06 27.2 0.0 5.8e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDK37878.1 - 5e-05 23.4 0.5 8e-05 22.7 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDK37878.1 - 5.6e-05 23.7 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDK37878.1 - 0.0052 17.0 0.6 0.0079 16.5 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDK37878.1 - 0.023 14.8 0.1 0.039 14.0 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Sds3 PF08598.11 EDK37879.2 - 2.5e-29 102.8 1.1 3.8e-29 102.2 1.1 1.3 1 0 0 1 1 1 1 Sds3-like Acetyltransf_1 PF00583.25 EDK37880.1 - 6.9e-05 23.1 0.1 0.00012 22.2 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK37880.1 - 0.037 14.4 0.1 0.09 13.2 0.1 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDK37880.1 - 0.043 14.5 0.0 0.085 13.5 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDK37880.1 - 0.066 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PolyA_pol_RNAbd PF12627.7 EDK37880.1 - 0.22 11.3 0.0 0.72 9.7 0.0 1.8 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A zf-H2C2 PF09337.10 EDK37881.2 - 2.5e-14 53.2 0.7 4.5e-14 52.4 0.7 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EDK37881.2 - 4.1e-10 39.6 0.2 8.1e-10 38.7 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EDK37881.2 - 7.4e-08 32.6 0.0 2.9e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK37881.2 - 0.0041 17.5 0.0 0.011 16.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDK37881.2 - 0.14 12.3 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK37881.2 - 0.18 11.8 0.0 0.9 9.6 0.0 2.0 2 0 0 2 2 2 0 FR47-like protein CPSase_L_D2 PF02786.17 EDK37882.2 - 7.9e-115 381.7 0.9 3.9e-84 281.4 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EDK37882.2 - 3.1e-48 162.8 0.0 7.2e-48 161.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 EDK37882.2 - 3e-47 160.4 0.0 6.9e-47 159.2 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 EDK37882.2 - 1.6e-44 152.0 0.0 4.4e-44 150.5 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EDK37882.2 - 9e-39 132.6 0.0 2.2e-38 131.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EDK37882.2 - 6.5e-28 97.8 0.0 2e-27 96.2 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EDK37882.2 - 5.7e-21 74.5 0.0 3.1e-20 72.2 0.0 2.4 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EDK37882.2 - 1.2e-18 67.4 1.7 1.5e-10 41.0 0.2 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDK37882.2 - 1e-15 57.7 1.1 1.2e-07 31.4 0.1 2.8 3 0 0 3 3 3 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EDK37882.2 - 2.2e-10 40.4 0.0 1.9e-05 24.4 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EDK37882.2 - 1.7e-07 31.4 0.4 0.0052 16.8 0.1 3.1 3 0 0 3 3 3 2 ATP-grasp domain Peptidase_C26 PF07722.13 EDK37882.2 - 3.6e-06 26.9 0.1 0.00063 19.6 0.1 2.9 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EDK37882.2 - 0.00027 20.8 0.2 0.051 13.4 0.0 4.0 4 0 0 4 4 3 1 DJ-1/PfpI family GARS_A PF01071.19 EDK37882.2 - 0.0021 17.9 0.6 0.69 9.6 0.1 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EDK37882.2 - 0.031 13.9 0.1 0.62 9.6 0.1 2.4 2 0 0 2 2 2 0 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 EDK37882.2 - 0.094 12.1 0.1 7.9 5.9 0.1 2.5 2 0 0 2 2 2 0 ATP-grasp domain TrkA_N PF02254.18 EDK37882.2 - 0.14 12.4 0.1 0.91 9.8 0.0 2.5 3 0 0 3 3 2 0 TrkA-N domain MFS_1 PF07690.16 EDK37883.2 - 4.4e-43 147.5 32.9 4.4e-43 147.5 32.9 2.5 3 0 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK37883.2 - 1.7e-08 33.8 7.1 1.7e-08 33.8 7.1 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter TrkH PF02386.16 EDK37884.2 - 2.1e-164 547.7 5.7 2.1e-164 547.7 5.7 2.0 2 0 0 2 2 2 2 Cation transport protein Brix PF04427.18 EDK37885.1 - 3.8e-30 105.4 1.7 5.4e-30 104.9 1.7 1.2 1 0 0 1 1 1 1 Brix domain Mif2_N PF15624.6 EDK37887.2 - 1.8 9.3 7.0 5.1 7.8 6.8 1.9 1 1 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal RICTOR_N PF14664.6 EDK37888.2 - 1.2e-106 356.9 0.9 2e-106 356.2 0.9 1.4 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 EDK37888.2 - 5e-30 103.4 0.2 5.4e-27 93.6 0.1 3.9 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EDK37888.2 - 1.5e-24 86.0 1.8 1e-23 83.3 0.2 3.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 EDK37888.2 - 2.7e-16 59.9 2.1 6.4e-15 55.5 0.0 4.2 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF2944 PF11161.8 EDK37888.2 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) CitG PF01874.16 EDK37889.2 - 0.061 13.0 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase ASF1_hist_chap PF04729.13 EDK37890.2 - 1.1e-71 239.8 0.0 1.5e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 EDK37890.2 - 1.1 7.4 18.8 1.2 7.3 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 EDK37890.2 - 2.8 7.7 7.5 4.3 7.1 7.5 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH BUD22 PF09073.10 EDK37890.2 - 5.3 6.3 17.0 6 6.1 17.0 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EDK37890.2 - 5.9 5.1 15.9 6.9 4.8 15.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EDK37890.2 - 6.6 6.1 20.2 7.2 5.9 20.2 1.1 1 0 0 1 1 1 0 SDA1 PTPRCAP PF15713.5 EDK37890.2 - 7.5 6.8 20.8 11 6.3 20.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Merozoite_SPAM PF07133.11 EDK37890.2 - 8.7 6.3 34.3 11 6.0 34.3 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Sporozoite_P67 PF05642.11 EDK37891.2 - 0.026 12.6 3.0 0.042 11.9 3.0 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen F-protein PF00469.20 EDK37891.2 - 0.053 13.1 4.7 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Zip PF02535.22 EDK37891.2 - 0.058 12.6 1.7 0.092 12.0 1.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Astro_capsid_p PF12226.8 EDK37891.2 - 2 7.5 12.4 1.1 8.3 6.2 2.3 2 0 0 2 2 2 0 Turkey astrovirus capsid protein CDC45 PF02724.14 EDK37891.2 - 2.1 6.6 8.1 4.3 5.5 8.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Roughex PF06020.11 EDK37891.2 - 2.1 7.3 12.3 0.53 9.3 9.2 1.5 1 1 0 1 1 1 0 Drosophila roughex protein DNA_pol_phi PF04931.13 EDK37891.2 - 2.2 6.3 14.7 3.5 5.6 14.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Mem_trans PF03547.18 EDK37892.2 - 3e-58 197.1 10.9 3.6e-58 196.8 10.9 1.0 1 0 0 1 1 1 1 Membrane transport protein Ras PF00071.22 EDK37893.2 - 8.5e-50 168.5 0.2 9.7e-50 168.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK37893.2 - 6e-18 65.2 0.0 8.6e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK37893.2 - 4.4e-07 29.5 0.0 4.8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK37893.2 - 4.7e-07 29.5 0.1 3.3e-06 26.8 0.0 2.1 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK37893.2 - 4.9e-05 23.4 0.0 7.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK37893.2 - 0.00012 22.1 0.4 0.0036 17.2 0.0 2.1 1 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EDK37893.2 - 0.00017 21.2 0.0 0.0012 18.4 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 EDK37893.2 - 0.00024 20.6 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EDK37893.2 - 0.045 13.8 0.0 0.077 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain GDA1_CD39 PF01150.17 EDK37894.2 - 7.5e-81 271.9 0.0 4.6e-80 269.4 0.0 1.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family CLTH PF10607.9 EDK37895.2 - 1.1e-33 116.2 1.3 1.1e-33 116.2 1.3 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain DUF2431 PF10354.9 EDK37896.2 - 5.1e-56 189.5 0.1 7.5e-56 189.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltr_RsmB-F PF01189.17 EDK37896.2 - 0.21 11.2 0.9 0.33 10.6 0.0 1.8 3 0 0 3 3 3 0 16S rRNA methyltransferase RsmB/F UCH PF00443.29 EDK37897.2 - 6.4e-44 150.4 0.0 1.2e-43 149.5 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK37897.2 - 1.4e-06 28.2 0.1 0.00015 21.5 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.22 EDK37898.2 - 2.4e-47 158.6 0.1 3.8e-16 58.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK37898.2 - 8.3e-12 44.8 0.0 3.5e-05 23.6 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EDK37898.2 - 0.00088 19.6 0.0 0.68 10.2 0.0 3.3 3 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 EDK37898.2 - 0.0019 18.2 0.0 0.76 9.8 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EDK37898.2 - 0.073 13.2 0.0 4.8 7.4 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif DUF424 PF04242.13 EDK37898.2 - 0.075 13.3 0.2 0.19 12.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF424) DUF3421 PF11901.8 EDK37898.2 - 0.14 12.1 0.1 14 5.7 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3421) Met_10 PF02475.16 EDK37899.1 - 3.7e-11 43.2 0.0 8.3e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein DUF2089 PF09862.9 EDK37899.1 - 0.059 13.4 1.1 3.1 7.9 0.0 3.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2089) MTS PF05175.14 EDK37899.1 - 0.1 12.1 0.0 0.29 10.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase small domain zf-C2H2 PF00096.26 EDK37900.2 - 1.4e-13 50.5 17.0 2.2e-06 27.8 4.9 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK37900.2 - 1.4e-12 47.4 12.5 2e-08 34.3 0.4 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK37900.2 - 2.8e-07 30.8 17.4 0.0028 18.3 3.4 4.2 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK37900.2 - 1.4e-05 25.0 7.1 0.0093 15.9 1.3 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK37900.2 - 5.7e-05 23.3 9.6 0.0058 16.9 0.6 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDK37900.2 - 7.8e-05 22.9 13.2 0.00031 21.0 0.9 4.7 5 0 0 5 5 5 1 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.6 EDK37900.2 - 0.034 14.7 2.5 0.043 14.3 0.7 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf_UBZ PF18439.1 EDK37900.2 - 0.15 11.7 1.7 0.43 10.2 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 EDK37900.2 - 0.25 11.3 0.1 0.25 11.3 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 EDK37900.2 - 0.32 11.5 5.4 1.5 9.3 1.5 3.1 2 1 1 3 3 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 EDK37900.2 - 0.34 11.2 2.5 1.2 9.5 2.6 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding FYVE PF01363.21 EDK37900.2 - 0.79 9.9 6.1 1.7 8.8 6.1 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf-C2H2_11 PF16622.5 EDK37900.2 - 1.7 8.5 9.3 0.94 9.3 0.1 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type LIM PF00412.22 EDK37900.2 - 1.8 8.9 3.7 39 4.6 0.4 2.5 1 1 1 2 2 2 0 LIM domain RebB PF11747.8 EDK37900.2 - 2.1 8.5 5.2 3.6 7.8 2.5 2.4 2 0 0 2 2 2 0 Killing trait Bac_surface_Ag PF01103.23 EDK37901.2 - 6.8e-45 154.0 3.2 9.5e-45 153.5 3.2 1.2 1 0 0 1 1 1 1 Surface antigen DUF3231 PF11553.8 EDK37901.2 - 0.14 11.7 0.1 0.24 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3231) DFP PF04127.15 EDK37903.2 - 1.9e-16 60.5 0.0 2.2e-09 37.4 0.0 2.2 1 1 1 2 2 2 2 DNA / pantothenate metabolism flavoprotein PIN_8 PF18476.1 EDK37903.2 - 0.011 15.7 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 PIN like domain Cyclin_N PF00134.23 EDK37904.2 - 8.4e-10 38.5 0.8 5.3e-09 35.9 0.5 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EDK37904.2 - 0.0014 19.0 0.2 0.0048 17.2 0.1 1.9 2 0 0 2 2 2 1 Cyclin C-terminal domain TFIIB PF00382.19 EDK37904.2 - 0.97 9.5 4.0 1.8 8.7 0.2 2.7 3 0 0 3 3 3 0 Transcription factor TFIIB repeat TRAM_LAG1_CLN8 PF03798.16 EDK37905.2 - 1e-39 136.3 27.9 1e-39 136.3 27.9 1.7 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EDK37905.2 - 9.4e-19 66.8 0.2 9.4e-19 66.8 0.2 2.2 2 0 0 2 2 2 1 TRAM1-like protein Aa_trans PF01490.18 EDK37906.2 - 1.1e-95 320.8 36.3 1.2e-95 320.6 36.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Kinesin PF00225.23 EDK37907.2 - 5.6e-109 364.1 0.0 7.5e-109 363.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDK37907.2 - 1.1e-19 70.9 0.0 2.1e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding SlyX PF04102.12 EDK37907.2 - 0.0067 17.0 0.6 0.062 13.9 0.1 2.7 2 0 0 2 2 2 1 SlyX Rick_17kDa_Anti PF05433.15 EDK37908.1 - 1.5e-07 31.1 12.3 1.5e-07 31.1 12.3 2.5 2 0 0 2 2 2 1 Glycine zipper 2TM domain Sel1 PF08238.12 EDK37909.2 - 1.8e-43 145.9 31.5 1.1e-06 29.1 0.1 8.3 8 0 0 8 8 8 7 Sel1 repeat UQ_con PF00179.26 EDK37910.2 - 6.8e-21 74.4 0.0 1e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Methyltransf_23 PF13489.6 EDK37911.2 - 5.8e-14 52.3 0.0 9.5e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK37911.2 - 2.9e-11 44.0 0.0 9.6e-11 42.3 0.0 1.9 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK37911.2 - 4.5e-11 43.3 0.0 8.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK37911.2 - 2e-10 41.1 0.0 4.3e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK37911.2 - 1.9e-09 37.5 0.0 4.7e-09 36.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK37911.2 - 1.2e-06 28.0 0.0 2.4e-06 27.0 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EDK37911.2 - 0.00021 21.4 0.0 0.00034 20.8 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EDK37911.2 - 0.011 15.2 0.0 0.029 13.9 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 EDK37911.2 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NNMT_PNMT_TEMT PF01234.17 EDK37911.2 - 0.1 11.8 0.0 0.31 10.2 0.0 1.6 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_32 PF13679.6 EDK37911.2 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain 2OG-Fe_Oxy_2 PF10014.9 EDK37912.2 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe dioxygenase Vps5 PF09325.10 EDK37912.2 - 0.015 14.8 0.9 0.023 14.3 0.9 1.2 1 0 0 1 1 1 0 Vps5 C terminal like HTH_54 PF18607.1 EDK37912.2 - 0.066 13.3 0.1 2 8.5 0.1 2.4 2 0 0 2 2 2 0 ParA helix turn helix domain Pkinase PF00069.25 EDK37913.2 - 1.6e-25 90.0 0.0 2.2e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK37913.2 - 3.8e-13 49.3 0.0 5.2e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK37913.2 - 4.8e-08 32.2 1.0 5.4e-08 32.0 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase PIP49_C PF12260.8 EDK37913.2 - 0.025 14.2 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 zf-AN1 PF01428.16 EDK37914.2 - 1.5e-10 41.0 8.7 2.6e-10 40.3 8.7 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger UPF1_Zn_bind PF09416.10 EDK37914.2 - 0.085 12.8 1.6 0.16 11.9 1.6 1.5 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) IQCJ-SCHIP1 PF15157.6 EDK37914.2 - 0.3 10.9 1.3 0.79 9.5 1.3 1.9 1 1 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif PSI_integrin PF17205.3 EDK37914.2 - 0.41 10.4 5.0 0.24 11.2 2.5 2.0 2 0 0 2 2 2 0 Integrin plexin domain zf-C5HC2 PF02928.16 EDK37914.2 - 0.95 9.9 7.3 1.9 8.9 7.3 1.5 1 0 0 1 1 1 0 C5HC2 zinc finger RNase_P_p30 PF01876.16 EDK37915.2 - 2.1e-76 256.2 0.0 2.7e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 Elongin_A PF06881.11 EDK37916.2 - 4.6e-28 97.8 0.1 8.1e-28 97.0 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A CRAL_TRIO PF00650.20 EDK37917.2 - 3e-38 131.1 0.0 4e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK37917.2 - 1.1e-17 63.9 0.7 2.4e-17 62.9 0.7 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain EXOSC1 PF10447.9 EDK37918.2 - 1.4e-43 147.9 0.3 2.4e-43 147.2 0.3 1.4 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 Globin PF00042.22 EDK37920.2 - 2.5e-06 28.0 0.0 9.1e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Globin YtxH PF12732.7 EDK37922.1 - 3.4 8.3 5.3 15 6.2 1.7 2.9 2 1 0 2 2 2 0 YtxH-like protein Ribosomal_S5 PF00333.20 EDK37923.1 - 6.5e-26 90.1 3.4 6.5e-26 90.1 3.4 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDK37923.1 - 5.4e-24 83.4 0.1 9.3e-24 82.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain CoA_binding_3 PF13727.6 EDK37923.1 - 0.0057 16.7 0.1 0.017 15.2 0.0 1.7 1 1 1 2 2 2 1 CoA-binding domain zf-CCCH_2 PF14608.6 EDK37924.2 - 2.8e-25 87.9 79.1 8.1e-06 26.1 4.3 7.2 7 0 0 7 7 7 6 RNA-binding, Nab2-type zinc finger Nab2p_Zf1 PF18260.1 EDK37924.2 - 0.0053 16.6 1.2 0.0053 16.6 1.2 3.5 4 0 0 4 4 4 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Nab2 PF11517.8 EDK37924.2 - 0.011 16.0 0.5 0.017 15.4 0.5 1.3 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) TFIIA PF03153.13 EDK37924.2 - 0.13 12.2 15.1 0.043 13.8 12.2 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EDK37924.2 - 0.15 11.6 12.4 0.25 10.9 12.4 1.3 1 0 0 1 1 1 0 Spt20 family FXMRP1_C_core PF12235.8 EDK37924.2 - 0.22 12.2 3.8 0.35 11.5 3.1 1.7 1 1 0 1 1 1 0 Fragile X-related 1 protein core C terminal PepSY_TM PF03929.16 EDK37924.2 - 0.92 9.1 1.8 1.6 8.3 1.8 1.3 1 0 0 1 1 1 0 PepSY-associated TM region ARS2 PF04959.13 EDK37924.2 - 3.4 8.0 11.2 0.31 11.4 5.7 1.9 2 0 0 2 2 2 0 Arsenite-resistance protein 2 CCDC53 PF10152.9 EDK37924.2 - 7.9 6.9 10.7 5.6 7.4 7.6 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex FUSC_2 PF13515.6 EDK37925.2 - 2.9e-33 114.7 3.7 2.9e-33 114.7 3.7 2.6 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EDK37925.2 - 1.5e-07 31.5 0.3 3.8e-07 30.2 0.3 1.6 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ALMT PF11744.8 EDK37925.2 - 7.6e-05 21.7 9.8 0.088 11.6 5.1 2.8 2 1 0 2 2 2 2 Aluminium activated malate transporter ArAE_2_N PF10337.9 EDK37925.2 - 0.0015 17.6 0.2 0.0034 16.5 0.2 1.5 1 0 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal FUSC PF04632.12 EDK37925.2 - 0.053 12.1 3.6 2.2 6.7 0.0 3.2 3 0 0 3 3 3 0 Fusaric acid resistance protein family ABC1 PF03109.16 EDK37926.2 - 4.3e-31 107.5 0.0 8.1e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family OB_NTP_bind PF07717.16 EDK37927.1 - 7.6e-24 83.9 0.0 2.8e-23 82.1 0.0 2.0 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDK37927.1 - 2.4e-20 72.8 0.1 5.9e-20 71.6 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK37927.1 - 1.9e-12 47.5 0.0 4.3e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDK37927.1 - 3.7e-08 33.3 0.2 7.5e-08 32.3 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK37927.1 - 1.4e-05 25.4 0.1 4.5e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EDK37927.1 - 8.7e-05 22.2 0.1 0.00024 20.8 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EDK37927.1 - 0.00088 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EDK37927.1 - 0.003 17.6 0.1 0.0063 16.5 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 EDK37927.1 - 0.0044 17.4 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDK37927.1 - 0.02 15.4 0.0 1.7 9.1 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 EDK37927.1 - 0.033 14.7 0.0 0.067 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDK37927.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Arf PF00025.21 EDK37928.1 - 1.2e-65 220.2 0.1 1.3e-65 220.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDK37928.1 - 1.5e-15 57.5 0.0 2e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK37928.1 - 3.4e-13 49.5 0.0 3.6e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDK37928.1 - 1.3e-12 47.6 0.8 5.8e-09 35.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EDK37928.1 - 3.2e-12 46.3 0.0 3.7e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDK37928.1 - 3e-09 36.6 0.0 3.7e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK37928.1 - 2.2e-05 24.5 0.0 3.1e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase MobB PF03205.14 EDK37928.1 - 0.026 14.4 0.1 0.039 13.9 0.1 1.4 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EDK37928.1 - 0.12 11.4 0.1 0.43 9.5 0.0 2.0 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 EDK37928.1 - 0.12 11.9 0.6 0.96 9.0 0.6 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B 6PF2K PF01591.18 EDK37928.1 - 0.18 11.1 0.1 0.31 10.3 0.1 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Rib_5-P_isom_A PF06026.14 EDK37929.2 - 3.1e-59 199.5 0.1 3.8e-59 199.2 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EDK37929.2 - 0.00036 20.5 0.1 0.099 12.6 0.0 2.3 1 1 1 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 EDK37929.2 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain DUF5622 PF18533.1 EDK37929.2 - 0.16 12.2 0.0 0.89 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5622) Ribosomal_S7e PF01251.18 EDK37930.1 - 1.7e-79 265.8 1.0 2e-79 265.7 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e SH3_1 PF00018.28 EDK37931.2 - 1.9e-24 85.0 0.4 4.1e-13 48.7 0.1 2.8 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EDK37931.2 - 2.8e-23 81.5 0.4 2.6e-14 52.8 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 EDK37931.2 - 4.6e-21 74.9 2.2 6.5e-21 74.4 0.1 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 EDK37931.2 - 1e-11 44.3 0.0 3.4e-08 33.0 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 EDK37931.2 - 0.0064 16.5 0.0 0.88 9.7 0.0 2.8 2 0 0 2 2 2 1 SH3 domain SH3_3 PF08239.11 EDK37931.2 - 0.0069 16.6 0.4 0.036 14.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial SH3 domain DUF2183 PF09949.9 EDK37932.2 - 1.2e-32 112.2 0.1 2.6e-32 111.1 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) MRP-L20 PF12824.7 EDK37932.2 - 0.14 12.3 1.3 0.26 11.4 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 DFRP_C PF16543.5 EDK37933.2 - 2.7e-22 79.1 6.4 2.7e-22 79.1 6.4 3.8 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EDK37933.2 - 2e-06 28.5 15.9 0.00015 22.4 6.4 3.8 2 1 1 3 3 3 2 Torus domain zf-CCCH PF00642.24 EDK37933.2 - 5e-06 26.3 0.8 5e-06 26.3 0.8 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK37933.2 - 2.5e-05 24.2 6.5 2.5e-05 24.2 6.5 3.2 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDK37933.2 - 5.2e-05 22.9 10.3 0.00013 21.6 2.2 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDK37933.2 - 0.0022 18.2 0.3 0.24 11.7 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EDK37933.2 - 2.3 8.8 14.5 0.55 10.8 5.1 2.7 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger MOR2-PAG1_N PF14222.6 EDK37934.2 - 1.8e-148 495.9 7.4 1.8e-148 495.9 7.4 2.1 3 0 0 3 3 3 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EDK37934.2 - 1.9e-89 299.9 4.4 2.8e-89 299.3 2.0 2.7 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EDK37934.2 - 4.8e-32 110.6 13.6 1.7e-18 65.8 0.5 4.1 1 1 1 3 3 3 3 Cell morphogenesis central region Cnd1 PF12717.7 EDK37934.2 - 0.0007 19.7 13.7 0.13 12.3 0.1 6.0 7 0 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDK37934.2 - 0.024 15.0 0.1 2.4 8.6 0.0 3.8 5 0 0 5 5 5 0 HEAT repeats MMS19_C PF12460.8 EDK37936.2 - 4e-91 306.2 15.0 4e-91 306.2 15.0 3.8 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EDK37936.2 - 1.7e-80 270.4 0.6 1.7e-80 270.4 0.6 3.3 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 EDK37936.2 - 1.8e-05 25.1 2.3 23 5.6 0.0 6.5 5 1 1 6 6 6 1 HEAT-like repeat Ipi1_N PF12333.8 EDK37936.2 - 0.031 14.9 5.7 1.5 9.4 0.1 4.0 4 1 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Nop52 PF05997.12 EDK37936.2 - 0.29 10.9 3.4 2 8.1 0.0 4.0 5 0 0 5 5 5 0 Nucleolar protein,Nop52 RRT14 PF17075.5 EDK37937.2 - 1.6e-59 201.4 27.2 1.9e-59 201.1 27.2 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 SCP2 PF02036.17 EDK37938.1 - 2.1e-22 79.5 2.9 2.4e-22 79.3 2.9 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EDK37938.1 - 0.00062 20.0 0.1 0.00082 19.6 0.1 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Phage_CI_C PF16452.5 EDK37938.1 - 0.0012 19.1 0.1 0.0027 17.9 0.1 1.6 1 1 0 1 1 1 1 Bacteriophage CI repressor C-terminal domain WD40 PF00400.32 EDK37939.2 - 1.1e-08 35.5 0.1 0.0031 18.3 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37939.2 - 9.9e-05 22.6 0.3 4.5 7.6 0.0 4.9 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3834 PF12916.7 EDK37939.2 - 0.034 13.4 0.2 0.18 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) DUF3875 PF12991.7 EDK37939.2 - 0.11 12.5 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) RisS_PPD PF16524.5 EDK37940.2 - 0.04 14.2 0.1 0.097 12.9 0.1 1.6 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS COG5 PF10392.9 EDK37940.2 - 0.077 13.2 12.3 0.11 12.7 4.3 3.5 1 1 2 3 3 3 0 Golgi transport complex subunit 5 Sec34 PF04136.15 EDK37940.2 - 0.12 12.3 9.7 0.16 11.9 2.3 2.8 1 1 2 3 3 3 0 Sec34-like family FlaC_arch PF05377.11 EDK37940.2 - 0.65 10.4 3.6 5.2 7.5 0.0 3.2 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) Cation_ATPase_C PF00689.21 EDK37941.2 - 4.6e-47 160.1 6.6 4.6e-47 160.1 6.6 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EDK37941.2 - 7.8e-38 129.8 0.1 7.8e-38 129.8 0.1 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EDK37941.2 - 1.9e-23 82.4 0.1 3.8e-23 81.4 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDK37941.2 - 8e-18 65.5 0.7 1.1e-16 61.8 0.7 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDK37941.2 - 5.1e-10 38.9 0.1 1.8e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDK37941.2 - 0.00011 22.1 0.2 0.0011 18.8 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rav1p_C PF12234.8 EDK37942.2 - 7.2e-219 728.4 0.1 9.5e-219 728.0 0.1 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal MFS_1 PF07690.16 EDK37943.2 - 1.7e-12 46.9 26.6 2.6e-12 46.3 26.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDK37943.2 - 5e-10 39.3 9.4 5e-10 39.3 9.4 2.5 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 Pyridoxal_deC PF00282.19 EDK37944.2 - 1.2e-70 238.2 0.0 1.5e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EDK37944.2 - 5.8e-07 29.1 0.0 7.6e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EDK37944.2 - 0.0055 15.7 0.0 0.0081 15.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V MMS1_N PF10433.9 EDK37945.2 - 3e-97 326.3 0.9 5.4e-97 325.4 0.9 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDK37945.2 - 6.3e-86 288.6 0.1 1.4e-85 287.5 0.1 1.6 1 0 0 1 1 1 1 CPSF A subunit region HPS3_N PF14761.6 EDK37945.2 - 0.051 13.1 1.3 4.7 6.7 0.0 3.5 4 0 0 4 4 4 0 Hermansky-Pudlak syndrome 3 Forkhead PF00250.18 EDK37946.2 - 1.6e-35 121.2 2.9 1.7e-35 121.2 1.0 2.1 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 EDK37946.2 - 1.6e-09 38.0 0.1 3.6e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 EDK37946.2 - 0.031 14.5 0.0 0.071 13.4 0.0 1.6 1 0 0 1 1 1 0 FHA domain Linker_histone PF00538.19 EDK37946.2 - 0.044 14.1 2.0 0.079 13.3 0.1 2.3 2 0 0 2 2 2 0 linker histone H1 and H5 family WD40 PF00400.32 EDK37947.2 - 2.7e-15 56.5 12.0 3.5e-06 27.6 0.5 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37947.2 - 8.6e-09 35.6 1.8 0.0097 16.2 0.0 4.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDK37947.2 - 1e-05 24.8 0.2 1.8e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 Coatomer WD associated region eIF2A PF08662.11 EDK37947.2 - 0.00013 21.9 0.9 0.2 11.5 0.1 3.1 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EDK37947.2 - 0.021 13.6 0.0 0.039 12.7 0.0 1.4 1 0 0 1 1 1 0 Nup133 N terminal like Vps8 PF12816.7 EDK37948.2 - 1.8e-48 164.7 4.5 2.8e-48 164.0 1.6 2.2 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 WD40 PF00400.32 EDK37948.2 - 1.2e-05 25.9 2.8 0.00061 20.6 0.1 4.3 3 0 0 3 3 3 1 WD domain, G-beta repeat Vps39_1 PF10366.9 EDK37948.2 - 1.8e-05 24.9 3.4 0.032 14.5 0.6 2.9 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 zf-RING_2 PF13639.6 EDK37948.2 - 0.0067 16.7 1.5 0.029 14.7 1.5 2.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDK37948.2 - 0.043 14.1 1.5 0.12 12.7 1.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK37948.2 - 0.047 13.6 1.0 0.14 12.1 1.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EDK37948.2 - 0.1 12.6 0.1 0.36 10.9 0.1 1.9 1 0 0 1 1 1 0 Zinc-finger zf-C3HC4_2 PF13923.6 EDK37948.2 - 0.15 12.0 1.3 0.39 10.6 1.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK37948.2 - 0.38 10.8 5.8 0.036 14.0 0.6 2.0 2 0 0 2 2 2 0 zinc-RING finger domain Chitin_synth_1N PF08407.11 EDK37949.2 - 2.8e-05 24.0 0.0 8.4e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_1 PF01644.17 EDK37950.1 - 3.7e-26 92.1 0.1 5.9e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 EDK37950.1 - 3.6e-22 78.7 0.0 1.8e-17 63.2 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDK37950.1 - 4.4e-16 59.4 6.7 5.2e-15 55.9 6.7 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDK37950.1 - 0.00028 20.9 0.0 0.00076 19.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDK37950.1 - 0.049 13.1 0.0 0.47 9.9 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 21 Cytochrom_B_C PF00032.17 EDK37950.1 - 0.73 10.1 7.3 2 8.7 0.0 3.0 2 1 1 3 3 3 0 Cytochrome b(C-terminal)/b6/petD E1-E2_ATPase PF00122.20 EDK37951.2 - 1.6e-46 158.1 8.5 4.6e-46 156.6 7.4 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDK37951.2 - 3.5e-19 69.9 0.1 8.8e-19 68.6 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK37951.2 - 0.0013 18.5 0.1 0.0025 17.6 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDK37951.2 - 0.026 14.6 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) DUF2818 PF10993.8 EDK37951.2 - 0.05 14.2 3.5 0.14 12.7 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2818) SIS_2 PF13580.6 EDK37951.2 - 0.084 12.9 0.1 1.1 9.2 0.0 2.5 2 1 0 2 2 2 0 SIS domain DUF2613 PF11021.8 EDK37951.2 - 5.9 7.1 6.7 27 5.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) RNA_pol_Rpc34 PF05158.12 EDK37952.2 - 5.4e-89 298.9 0.1 6.3e-89 298.7 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 EDK37952.2 - 0.03 15.0 0.1 0.07 13.8 0.0 1.7 2 0 0 2 2 2 0 Replication protein A C terminal Rrf2 PF02082.20 EDK37952.2 - 0.032 14.6 0.3 0.075 13.4 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator Phasin_2 PF09361.10 EDK37952.2 - 0.062 13.6 0.3 0.13 12.6 0.3 1.5 1 0 0 1 1 1 0 Phasin protein AIP3 PF03915.13 EDK37953.2 - 0.013 14.6 0.7 0.013 14.6 0.7 1.6 2 0 0 2 2 2 0 Actin interacting protein 3 DUF4201 PF13870.6 EDK37953.2 - 0.013 15.2 0.7 0.022 14.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 EDK37953.2 - 0.037 14.5 3.0 0.085 13.3 3.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein F_actin_bind PF08919.10 EDK37953.2 - 0.042 13.9 0.3 0.091 12.9 0.3 1.5 1 0 0 1 1 1 0 F-actin binding ZapB PF06005.12 EDK37953.2 - 0.052 14.0 0.8 0.11 12.9 0.8 1.7 1 0 0 1 1 1 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 EDK37953.2 - 0.06 13.4 3.2 0.22 11.5 3.2 2.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Syntaxin-6_N PF09177.11 EDK37953.2 - 0.079 13.5 1.5 0.16 12.5 0.3 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF3552 PF12072.8 EDK37953.2 - 0.094 12.1 3.1 0.2 11.1 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF1664 PF07889.12 EDK37953.2 - 0.095 12.7 1.2 0.18 11.8 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 EDK37953.2 - 0.1 12.0 0.4 0.17 11.2 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.9 EDK37953.2 - 0.11 11.1 2.9 0.12 10.9 2.9 1.1 1 0 0 1 1 1 0 Macoilin family LMBR1 PF04791.16 EDK37953.2 - 0.37 9.6 0.5 0.53 9.1 0.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4140 PF13600.6 EDK37953.2 - 2 8.9 4.8 8.7 6.9 3.7 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) LPP PF04728.13 EDK37953.2 - 2.8 8.4 6.8 5.9 7.4 3.8 2.5 1 1 1 2 2 2 0 Lipoprotein leucine-zipper ATG16 PF08614.11 EDK37953.2 - 3.3 7.9 9.4 0.13 12.5 1.9 2.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 EDK37953.2 - 3.3 7.5 4.9 8.3 6.3 1.5 2.3 1 1 1 2 2 2 0 Septum formation initiator OTCace PF00185.24 EDK37954.2 - 2.8e-44 150.9 0.1 4.8e-44 150.2 0.1 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EDK37954.2 - 1.5e-43 148.3 0.3 3.3e-43 147.2 0.1 1.6 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Sod_Cu PF00080.20 EDK37955.2 - 3.7e-10 40.1 0.1 6.4e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PhoD_N PF16655.5 EDK37955.2 - 0.13 12.8 0.0 24 5.6 0.0 2.8 3 0 0 3 3 3 0 PhoD-like phosphatase, N-terminal domain Epimerase PF01370.21 EDK37956.1 - 7e-12 45.3 0.0 8.2e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK37956.1 - 1.3e-11 44.1 0.0 1.5e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK37956.1 - 2.6e-11 43.8 0.0 3e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK37956.1 - 2e-09 37.0 0.1 0.00032 20.0 0.0 2.0 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EDK37956.1 - 4.3e-05 23.2 0.4 8.7e-05 22.2 0.4 1.5 1 1 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EDK37956.1 - 5.1e-05 22.8 0.2 0.00013 21.5 0.2 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDK37956.1 - 0.0045 16.5 0.0 0.0064 16.0 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Shikimate_DH PF01488.20 EDK37956.1 - 0.024 14.7 0.0 0.072 13.1 0.0 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 EDK37956.1 - 0.033 13.3 0.0 0.043 13.0 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EDK37956.1 - 0.036 14.6 0.0 0.069 13.7 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DCP1 PF06058.13 EDK37956.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Dcp1-like decapping family adh_short_C2 PF13561.6 EDK37956.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.6 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DUF3606 PF12244.8 EDK37956.1 - 0.14 12.1 0.9 16 5.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) Response_reg PF00072.24 EDK37956.1 - 0.19 11.9 0.0 4.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Response regulator receiver domain DUF3589 PF12141.8 EDK37957.2 - 4.5e-177 589.6 0.0 5.3e-177 589.3 0.0 1.0 1 0 0 1 1 1 1 Beta-mannosyltransferases WD40 PF00400.32 EDK37958.2 - 2.6e-13 50.2 13.6 3.9e-06 27.5 0.0 9.3 9 0 0 9 9 9 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37958.2 - 0.014 15.6 0.0 1.3 9.4 0.0 3.9 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain YmzC PF14157.6 EDK37958.2 - 0.12 12.5 0.0 0.12 12.5 0.0 2.4 3 0 0 3 3 3 0 YmzC-like protein tRNA-synt_1 PF00133.22 EDK37959.2 - 1.1e-231 770.3 0.6 1.9e-231 769.5 0.6 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDK37959.2 - 2.8e-26 92.3 0.3 1.1e-25 90.3 0.1 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDK37959.2 - 7.5e-16 57.9 1.5 1.2e-06 27.6 0.1 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDK37959.2 - 0.002 17.5 0.0 0.0067 15.8 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 EDK37959.2 - 0.056 13.0 0.1 0.65 9.5 0.1 2.3 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 AHSP PF09236.10 EDK37959.2 - 0.069 13.6 0.0 0.2 12.1 0.0 1.8 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein ATP_bind_3 PF01171.20 EDK37960.2 - 5.7e-45 153.3 0.0 8.4e-45 152.8 0.0 1.3 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 EDK37960.2 - 0.0021 17.8 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 EDK37960.2 - 0.004 16.0 0.0 0.0075 15.1 0.0 1.4 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 EDK37960.2 - 0.031 13.8 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Peptidase_M1_N PF17900.1 EDK37961.2 - 8.1e-07 29.4 1.1 0.015 15.5 0.4 2.9 1 1 0 2 2 2 2 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 EDK37961.2 - 0.0086 15.7 0.0 0.021 14.4 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M1 domain VPS9 PF02204.18 EDK37962.2 - 1.1e-27 96.3 0.2 2.2e-27 95.3 0.2 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EDK37962.2 - 1e-11 45.0 0.7 3.7e-11 43.2 0.7 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EDK37962.2 - 8.9e-05 22.1 0.2 0.00023 20.8 0.1 1.7 2 0 0 2 2 2 1 CUE domain Cupin_3 PF05899.12 EDK37963.2 - 1.2e-07 31.3 0.5 1.7e-07 30.8 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 EDK37963.2 - 1.5e-06 28.1 0.0 1.8e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_2 PF07883.11 EDK37963.2 - 0.0013 18.4 0.1 0.0019 17.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain DUF1953 PF09196.10 EDK37963.2 - 0.059 13.2 0.1 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) Pirin PF02678.16 EDK37963.2 - 0.11 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Pirin CDC37_N PF03234.14 EDK37964.2 - 4.6e-43 147.2 7.7 4.6e-43 147.2 7.7 3.4 2 1 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EDK37964.2 - 1.1e-42 144.7 0.8 3.7e-42 143.0 0.8 2.0 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EDK37964.2 - 5.2e-20 71.4 1.7 1.6e-19 69.9 0.5 2.4 2 0 0 2 2 2 1 Cdc37 C terminal domain CoA_binding_3 PF13727.6 EDK37964.2 - 0.077 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 CoA-binding domain MbeB_N PF04837.12 EDK37964.2 - 0.078 13.3 0.3 0.078 13.3 0.3 2.5 2 0 0 2 2 2 0 MbeB-like, N-term conserved region GFO_IDH_MocA PF01408.22 EDK37965.2 - 2.9e-16 60.4 1.0 6.7e-16 59.2 0.1 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDK37965.2 - 0.0001 22.3 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain RRM_1 PF00076.22 EDK37966.2 - 5.1e-10 39.0 0.1 4.6e-09 36.0 0.0 2.5 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec20 PF03908.13 EDK37967.2 - 4.4e-25 87.4 1.9 1.4e-24 85.8 1.9 1.9 1 0 0 1 1 1 1 Sec20 Synaptobrevin PF00957.21 EDK37967.2 - 0.083 12.7 1.3 0.21 11.4 1.3 1.7 1 0 0 1 1 1 0 Synaptobrevin DUF948 PF06103.11 EDK37967.2 - 0.77 10.1 4.1 11 6.3 2.3 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Med2 PF11214.8 EDK37967.2 - 1.2 9.3 10.1 3.8 7.7 4.4 2.6 3 0 0 3 3 3 0 Mediator complex subunit 2 NPV_P10 PF05531.12 EDK37967.2 - 5.6 7.5 8.8 0.31 11.5 1.5 2.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Exo_endo_phos PF03372.23 EDK37968.2 - 1.2e-21 77.3 0.0 2.1e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mob1_phocein PF03637.17 EDK37969.2 - 1.8e-73 246.1 0.7 2.3e-73 245.8 0.7 1.1 1 0 0 1 1 1 1 Mob1/phocein family Fe-S_biosyn PF01521.20 EDK37972.2 - 1.4e-19 70.3 0.0 2.3e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3418 PF11898.8 EDK37972.2 - 0.05 12.3 0.0 0.072 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) TBX PF12598.8 EDK37972.2 - 1.8 9.4 10.0 0.17 12.7 5.2 1.8 2 0 0 2 2 2 0 T-box transcription factor Creatinase_N_2 PF16189.5 EDK37973.2 - 4.3e-48 163.5 0.9 2.7e-47 160.8 0.1 2.4 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EDK37973.2 - 1.1e-42 146.1 0.0 1.7e-42 145.5 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EDK37973.2 - 1.5e-23 82.6 2.1 4.2e-23 81.2 0.4 2.7 3 0 0 3 3 3 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EDK37973.2 - 2.1e-17 64.0 0.1 6.3e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Cir_Bir_Yir PF06022.11 EDK37975.2 - 0.041 13.4 0.6 0.076 12.5 0.1 1.6 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir Tup_N PF08581.10 EDK37975.2 - 0.087 13.1 0.3 0.48 10.8 0.1 2.1 2 0 0 2 2 2 0 Tup N-terminal Rep_fac-A_C PF08646.10 EDK37976.2 - 2.6e-53 179.7 3.9 2.1e-49 167.0 0.4 3.1 2 1 1 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDK37976.2 - 8.2e-35 118.7 1.2 2.7e-33 113.8 0.2 2.9 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EDK37976.2 - 1.2e-14 54.0 0.3 3.1e-08 33.5 0.0 4.0 3 1 1 4 4 4 3 OB-fold nucleic acid binding domain POT1 PF02765.17 EDK37976.2 - 5.5e-05 23.0 0.3 0.59 10.0 0.1 3.5 3 1 0 3 3 3 2 Telomeric single stranded DNA binding POT1/CDC13 CDC24_OB3 PF17244.2 EDK37976.2 - 0.00013 21.8 0.4 0.0076 16.0 0.4 2.7 1 1 0 1 1 1 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 EDK37976.2 - 0.0011 19.2 0.3 0.0028 17.9 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF223 Cys_Met_Meta_PP PF01053.20 EDK37977.1 - 2.1e-131 438.0 0.0 2.4e-131 437.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK37977.1 - 0.0025 17.0 0.0 0.0036 16.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK37977.1 - 0.044 13.1 0.0 0.36 10.1 0.0 2.2 2 1 1 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family Dioxygenase_C PF00775.21 EDK37977.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase 2Fe-2S_thioredx PF01257.19 EDK37978.1 - 3.9e-62 208.4 0.2 4.9e-62 208.1 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin WD40 PF00400.32 EDK37979.2 - 4.8e-24 84.2 21.8 3.6e-05 24.4 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK37979.2 - 7.7e-18 64.6 7.7 2.1e-07 31.1 0.5 4.4 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK37979.2 - 8.2e-07 29.1 0.6 0.12 12.3 0.1 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDK37979.2 - 0.0023 17.0 0.1 0.03 13.3 0.0 2.3 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Aminotran_1_2 PF00155.21 EDK37980.2 - 3.9e-21 75.6 0.0 5.2e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDK37980.2 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.7 EDK37980.2 - 0.068 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase WD40 PF00400.32 EDK37981.2 - 4.9e-14 52.5 8.4 0.0062 17.4 0.0 6.5 4 2 1 5 5 5 4 WD domain, G-beta repeat Hira PF07569.11 EDK37981.2 - 3.4e-13 49.8 0.1 8.3e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split HIRA_B PF09453.10 EDK37981.2 - 1.4e-10 40.7 0.7 4.1e-10 39.2 0.7 1.8 1 0 0 1 1 1 1 HIRA B motif ANAPC4_WD40 PF12894.7 EDK37981.2 - 6.2e-07 29.6 0.0 0.44 10.9 0.0 5.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK37981.2 - 0.073 12.9 0.0 3.4 7.5 0.0 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EDK37981.2 - 0.078 12.9 0.2 8.2 6.5 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat CHD5 PF04420.14 EDK37982.2 - 1.7e-48 164.5 1.9 2.2e-48 164.1 1.9 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF2252 PF10009.9 EDK37982.2 - 0.0018 17.4 0.1 0.0024 17.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) DivIC PF04977.15 EDK37982.2 - 0.044 13.6 1.0 0.044 13.6 1.0 1.7 2 0 0 2 2 2 0 Septum formation initiator CK_II_beta PF01214.18 EDK37983.2 - 1.6e-67 226.8 0.0 2.1e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.13 EDK37984.2 - 1.3e-17 64.0 5.2 2.7e-17 63.0 5.2 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EDK37984.2 - 0.00057 20.0 0.9 0.0086 16.2 0.0 3.2 2 2 1 3 3 3 1 DnaJ domain zf-CCCH PF00642.24 EDK37985.2 - 5.6e-10 38.9 1.2 1.2e-09 37.8 1.2 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EDK37985.2 - 1.6e-07 31.1 7.0 3.2e-07 30.1 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 EDK37985.2 - 6.1e-07 29.3 3.6 1.3e-06 28.2 3.6 1.6 1 0 0 1 1 1 1 Zinc finger domain Prok-RING_4 PF14447.6 EDK37985.2 - 5.7e-06 26.1 6.3 1.1e-05 25.2 6.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDK37985.2 - 1.1e-05 25.3 11.5 2.2e-05 24.3 11.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDK37985.2 - 1.2e-05 25.0 11.5 1.2e-05 25.0 11.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK37985.2 - 1.8e-05 24.9 9.1 4.2e-05 23.8 9.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EDK37985.2 - 3.5e-05 23.7 10.5 9.1e-05 22.4 10.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDK37985.2 - 4e-05 23.4 12.0 8.2e-05 22.4 12.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK37985.2 - 0.00035 20.6 8.3 0.00035 20.6 8.3 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 EDK37985.2 - 0.00064 19.5 1.3 0.0018 18.1 1.3 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-RING_6 PF14835.6 EDK37985.2 - 0.016 15.0 3.8 0.038 13.9 3.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein CvfB_WH PF17783.1 EDK37985.2 - 0.07 13.0 0.1 0.22 11.3 0.1 1.8 1 0 0 1 1 1 0 CvfB-like winged helix domain Red1 PF07964.11 EDK37985.2 - 0.077 11.2 9.6 0.093 11.0 9.6 1.1 1 0 0 1 1 1 0 Rec10 / Red1 zf-CCCH_2 PF14608.6 EDK37985.2 - 0.096 13.2 1.7 0.096 13.2 1.7 2.0 2 0 0 2 2 1 0 RNA-binding, Nab2-type zinc finger zf-RING_10 PF16685.5 EDK37985.2 - 0.21 11.7 11.4 0.11 12.6 8.4 2.0 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-Nse PF11789.8 EDK37985.2 - 0.29 11.0 5.3 0.61 9.9 5.3 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Presenilin PF01080.17 EDK37985.2 - 1.5 7.5 5.9 1.6 7.4 5.9 1.1 1 0 0 1 1 1 0 Presenilin Pap_E4 PF02711.14 EDK37985.2 - 5.1 8.1 8.0 1.6 9.8 3.8 2.1 1 1 1 2 2 2 0 E4 protein DUF4112 PF13430.6 EDK37986.2 - 2.7e-21 75.8 0.1 3.4e-21 75.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) CTP_transf_like PF01467.26 EDK37987.2 - 9.1e-29 100.5 0.0 3.9e-15 56.3 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EDK37987.2 - 3.4e-05 23.8 0.0 0.0056 16.6 0.0 2.3 2 0 0 2 2 2 2 FAD synthetase HABP4_PAI-RBP1 PF04774.15 EDK37988.2 - 0.0058 17.5 1.9 0.0058 17.5 1.9 1.5 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family ATE_C PF04377.15 EDK37989.2 - 5.2e-51 172.8 0.9 5.2e-51 172.8 0.9 1.7 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EDK37989.2 - 3.7e-27 94.5 3.6 8.7e-27 93.3 3.6 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus ARTD15_N PF18084.1 EDK37989.2 - 0.016 15.4 0.0 0.044 14.0 0.0 1.7 1 0 0 1 1 1 0 ARTD15 N-terminal domain TFIIF_beta_N PF17683.1 EDK37990.2 - 4.7e-34 118.0 0.1 1.3e-33 116.5 0.1 1.8 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EDK37990.2 - 8.7e-30 102.7 0.3 2.3e-29 101.3 0.3 1.7 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 EDK37990.2 - 0.0011 19.8 0.1 0.0023 18.7 0.1 1.8 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Ribosomal_L38e PF01781.18 EDK37991.1 - 3.2e-28 97.6 3.4 3.9e-28 97.3 3.4 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF669 PF05037.13 EDK37991.1 - 0.033 14.3 0.7 0.053 13.6 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF669) Prp18 PF02840.15 EDK37992.2 - 7.3e-30 103.9 0.2 7.3e-30 103.9 0.2 2.6 1 1 2 3 3 3 1 Prp18 domain GalP_UDP_tr_C PF02744.17 EDK37992.2 - 0.025 14.3 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Presenilin PF01080.17 EDK37992.2 - 0.061 12.1 2.1 0.07 11.9 2.1 1.2 1 0 0 1 1 1 0 Presenilin CAS_C PF12026.8 EDK37992.2 - 0.25 11.4 4.6 0.38 10.8 4.6 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Pex24p PF06398.11 EDK37993.2 - 2.1e-104 349.4 6.6 2.5e-104 349.2 6.6 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Wzy_C PF04932.15 EDK37993.2 - 0.0015 18.2 0.7 0.93 9.1 0.1 2.3 2 0 0 2 2 2 2 O-Antigen ligase Uricase PF01014.18 EDK37994.1 - 1.6e-63 212.8 0.5 6.9e-36 123.4 0.1 2.0 2 0 0 2 2 2 2 Uricase EutQ PF06249.12 EDK37994.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ ThiF PF00899.21 EDK37995.2 - 4.7e-48 163.7 0.0 7.3e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EDK37995.2 - 9.8e-05 22.6 0.1 0.064 13.5 0.1 2.4 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EDK37995.2 - 0.0023 17.6 0.1 0.0041 16.7 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EDK37995.2 - 0.022 14.8 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EDK37995.2 - 0.028 14.1 0.1 0.056 13.1 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EDK37995.2 - 0.032 13.5 0.7 0.047 12.9 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK37995.2 - 0.039 13.5 1.2 0.063 12.9 1.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Ldh_1_N PF00056.23 EDK37995.2 - 0.042 13.9 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain CagA PF03507.13 EDK37995.2 - 0.054 13.4 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 CagA exotoxin FAD_binding_3 PF01494.19 EDK37995.2 - 0.12 11.6 0.4 0.21 10.8 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EDK37995.2 - 0.12 12.6 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 EDK37995.2 - 0.25 11.9 1.1 0.97 10.0 0.3 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF1279 PF06916.13 EDK37996.2 - 1.1e-28 99.6 0.0 2e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF3196 PF11428.8 EDK37996.2 - 0.069 12.7 0.2 0.094 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3196) PCDO_beta_N PF12391.8 EDK37996.2 - 0.1 12.3 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal Bac_small_YrzI PF09501.10 EDK37996.2 - 0.2 11.8 4.3 0.22 11.7 3.4 1.6 1 1 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) Mito_carr PF00153.27 EDK37997.2 - 4.8e-58 193.1 2.1 6.8e-21 74.0 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDK37997.2 - 0.022 13.9 0.0 2.3 7.3 0.0 2.6 2 1 1 3 3 3 0 Gammaproteobacterial serine protease BEN PF10523.9 EDK37997.2 - 0.13 12.5 0.0 0.49 10.7 0.0 1.9 1 0 0 1 1 1 0 BEN domain NDT80_PhoG PF05224.12 EDK37998.2 - 2.3e-64 217.1 0.3 2.3e-64 217.1 0.3 1.7 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family REC114-like PF15165.6 EDK37998.2 - 5.1 6.8 7.6 8.4 6.1 7.6 1.2 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like TFIIA PF03153.13 EDK37998.2 - 8.2 6.3 12.1 12 5.8 12.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glucan_synthase PF02364.15 EDK37999.2 - 0 1136.0 0.9 0 1135.6 0.9 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDK37999.2 - 1.8e-33 115.7 7.8 1.2e-31 109.8 7.8 2.5 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 PDEase_I_N PF08499.12 EDK38000.2 - 0.77 9.6 5.0 0.63 9.9 0.2 2.8 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal NFACT-C PF11923.8 EDK38000.2 - 1.4 8.8 5.6 3.7 7.5 0.1 3.5 3 0 0 3 3 3 0 NFACT protein C-terminal domain Glyco_hydro_72 PF03198.14 EDK38001.2 - 1.1e-146 488.1 11.5 1.5e-146 487.6 11.5 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EDK38001.2 - 4.4e-28 97.8 2.5 1.3e-27 96.3 2.5 1.9 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 EDK38001.2 - 1.3e-06 28.0 1.6 3.5e-06 26.7 1.6 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EDK38001.2 - 0.0022 17.2 1.5 0.005 16.0 1.5 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Gsf2 PF11055.8 EDK38002.2 - 2.3e-144 480.8 0.1 2.6e-144 480.6 0.1 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 Meth_synt_2 PF01717.18 EDK38003.1 - 1.1e-152 508.0 0.0 5.5e-148 492.5 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EDK38003.1 - 2.7e-118 395.1 0.0 3.9e-112 374.8 0.0 2.5 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain DUF3502 PF12010.8 EDK38003.1 - 0.078 13.6 0.2 5 7.8 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) YolD PF08863.10 EDK38003.1 - 0.098 12.7 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 YolD-like protein gp12-short_mid PF09089.10 EDK38003.1 - 0.14 12.3 0.0 0.48 10.6 0.0 1.8 2 0 0 2 2 2 0 Phage short tail fibre protein gp12, middle domain SEP PF08059.13 EDK38004.2 - 3.3e-23 82.0 1.2 4.4e-23 81.6 0.1 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EDK38004.2 - 9.5e-17 61.0 0.1 2.4e-16 59.7 0.0 1.8 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.6 EDK38004.2 - 2.5e-11 43.2 0.1 4.8e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain LRR_8 PF13855.6 EDK38006.2 - 1.8e-21 75.6 32.0 0.0003 20.5 0.1 10.0 6 2 3 10 10 10 7 Leucine rich repeat LRR_4 PF12799.7 EDK38006.2 - 2.6e-16 59.5 50.7 0.0086 16.5 6.1 11.8 8 5 6 14 14 14 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK38006.2 - 0.0041 17.1 30.7 12 6.2 0.2 12.6 15 0 0 15 15 15 1 Leucine Rich repeat FNIP PF05725.12 EDK38006.2 - 0.0052 16.9 19.4 0.1 12.8 0.0 7.3 8 2 1 9 9 9 2 FNIP Repeat LRR_1 PF00560.33 EDK38006.2 - 2.8 8.8 34.0 18 6.3 0.7 11.6 10 3 0 10 10 10 0 Leucine Rich Repeat FAS_I_H PF18314.1 EDK38007.1 - 1.3e-74 250.2 0.3 2.9e-74 249.1 0.3 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EDK38007.1 - 8.6e-72 240.8 0.0 3.2e-71 238.9 0.0 2.0 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EDK38007.1 - 1.6e-21 77.1 0.1 3.2e-21 76.1 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EDK38007.1 - 4.3e-15 55.8 0.0 1.1e-14 54.6 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EDK38007.1 - 1e-12 48.1 0.0 3.2e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EDK38007.1 - 6e-05 22.6 0.0 0.00015 21.3 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK38007.1 - 0.0041 17.1 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 KR domain PP1_inhibitor PF05361.12 EDK38007.1 - 0.041 13.9 0.3 0.096 12.7 0.3 1.6 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor F420_oxidored PF03807.17 EDK38007.1 - 0.057 14.0 0.0 0.22 12.1 0.0 2.0 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent BCDHK_Adom3 PF10436.9 EDK38008.2 - 0.0017 18.2 1.8 0.0017 18.2 0.0 1.9 2 1 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF5407 PF17401.2 EDK38008.2 - 0.34 11.2 3.3 3.9 7.8 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5407) DCB PF16213.5 EDK38009.2 - 7.1e-08 32.3 0.1 1e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 UcrQ PF02939.16 EDK38009.2 - 0.014 15.3 0.1 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 UcrQ family BNIP3 PF06553.12 EDK38009.2 - 0.038 13.6 2.0 0.088 12.5 2.0 1.7 1 0 0 1 1 1 0 BNIP3 DEP PF00610.21 EDK38009.2 - 0.098 12.7 0.1 1.1 9.3 0.0 2.5 2 1 1 3 3 3 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) AIF-MLS PF14962.6 EDK38009.2 - 1.6 8.6 9.7 1.5 8.8 8.1 1.7 1 1 0 1 1 1 0 Mitochondria Localisation Sequence Sec7_N PF12783.7 EDK38010.2 - 5e-09 36.2 0.3 1.1e-08 35.1 0.2 1.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Sec7 PF01369.20 EDK38010.2 - 1.8e-05 24.5 0.1 3e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.10 EDK38011.2 - 2e-33 114.1 2.4 2e-33 114.1 2.4 4.9 6 0 0 6 6 6 2 Domain of unknown function (DUF1981) Sec7 PF01369.20 EDK38011.2 - 3.4e-29 101.8 3.2 4e-29 101.6 0.4 2.6 3 0 0 3 3 3 1 Sec7 domain Mitovir_RNA_pol PF05919.11 EDK38011.2 - 0.0022 17.2 10.3 0.055 12.6 1.3 3.0 2 2 0 2 2 2 2 Mitovirus RNA-dependent RNA polymerase Cnd3 PF12719.7 EDK38011.2 - 0.014 14.6 2.4 5.4 6.1 0.0 3.8 3 1 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain XPG_I_2 PF12813.7 EDK38011.2 - 0.056 12.9 0.3 0.12 11.9 0.3 1.5 1 0 0 1 1 1 0 XPG domain containing Stm1_N PF09598.10 EDK38012.1 - 9.3e-09 36.0 2.8 9.3e-09 36.0 2.8 4.2 3 2 1 4 4 4 1 Stm1 Stb3 PF10330.9 EDK38013.2 - 2.3e-30 104.5 0.0 5.7e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 Putative Sin3 binding protein MCM PF00493.23 EDK38014.2 - 2.2e-100 334.4 0.0 3.9e-100 333.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDK38014.2 - 8.9e-33 112.8 0.2 1.6e-32 112.0 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDK38014.2 - 1.6e-21 76.5 0.2 4.7e-21 75.0 0.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDK38014.2 - 2.8e-17 63.2 0.4 8.3e-17 61.7 0.4 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDK38014.2 - 9.5e-08 31.7 0.0 1.6e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDK38014.2 - 9.8e-08 32.1 0.0 1.6e-06 28.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EDK38014.2 - 0.0026 17.5 0.1 0.0068 16.2 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 EDK38014.2 - 0.019 14.8 0.0 0.059 13.2 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EDK38014.2 - 0.14 12.6 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-UDP PF14569.6 EDK38014.2 - 0.15 12.2 0.4 0.32 11.1 0.4 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Sigma54_activat PF00158.26 EDK38014.2 - 0.16 11.7 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF202 PF02656.15 EDK38015.2 - 3.6e-17 62.6 3.9 6.3e-17 61.8 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PTS_EIIC PF02378.18 EDK38015.2 - 0.013 14.5 1.8 0.015 14.3 1.8 1.2 1 0 0 1 1 1 0 Phosphotransferase system, EIIC TMEM141 PF15110.6 EDK38015.2 - 0.046 14.3 0.3 0.09 13.4 0.3 1.4 1 0 0 1 1 1 0 TMEM141 protein family Memo PF01875.17 EDK38015.2 - 0.077 12.1 0.0 0.094 11.8 0.0 1.1 1 0 0 1 1 1 0 Memo-like protein Tho1_MOS11_C PF18592.1 EDK38016.1 - 1e-21 76.5 2.9 2.3e-21 75.3 2.9 1.7 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 EDK38016.1 - 8.5e-13 47.7 0.1 2e-12 46.6 0.1 1.7 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 EDK38016.1 - 0.049 13.4 0.2 0.14 11.9 0.2 1.8 1 1 0 1 1 1 0 HeH/LEM domain FYTT PF07078.11 EDK38016.1 - 0.46 9.8 5.7 0.19 11.0 1.7 1.9 1 1 1 2 2 2 0 Forty-two-three protein DUF2868 PF11067.8 EDK38016.1 - 1.2 8.6 2.5 1.5 8.3 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Peptidase_M1 PF01433.20 EDK38019.2 - 1.2e-77 260.4 2.0 1.2e-77 260.4 2.0 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDK38019.2 - 1.3e-58 199.0 0.1 2.1e-58 198.3 0.1 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDK38019.2 - 1.7e-49 168.6 0.3 5.3e-49 166.9 0.1 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain BSP PF04450.12 EDK38019.2 - 0.031 14.1 0.1 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase of plants and bacteria SWM_repeat PF13753.6 EDK38019.2 - 0.11 12.6 0.4 0.37 11.0 0.4 1.9 1 0 0 1 1 1 0 Putative flagellar system-associated repeat Asn_synthase PF00733.21 EDK38020.1 - 4.3e-94 316.1 0.1 1.3e-52 179.7 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDK38020.1 - 1.9e-33 115.0 0.0 3.5e-33 114.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDK38020.1 - 2.1e-26 92.7 0.0 4.7e-26 91.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDK38020.1 - 3.7e-06 26.5 0.0 2.1e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 Aluminium induced protein NAD_synthase PF02540.17 EDK38020.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 NAD synthase CSN8_PSD8_EIF3K PF10075.9 EDK38021.2 - 5.6e-18 65.3 0.2 5.6e-18 65.3 0.2 1.7 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EDK38021.2 - 0.00098 18.6 0.5 0.00098 18.6 0.5 1.5 1 1 1 2 2 2 1 SAC3/GANP family VPS28 PF03997.12 EDK38022.2 - 2.7e-65 219.6 0.2 3.4e-65 219.3 0.2 1.1 1 0 0 1 1 1 1 VPS28 protein Steroid_dh PF02544.16 EDK38024.2 - 2.1e-10 40.8 1.7 2.1e-10 40.8 1.7 2.2 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Transp_cyt_pur PF02133.15 EDK38025.1 - 6.2e-73 246.1 36.9 7.1e-73 245.9 36.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Syntaxin PF00804.25 EDK38026.1 - 2.3e-22 79.7 18.9 3.8e-22 79.0 18.9 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EDK38026.1 - 3e-10 39.9 2.3 3e-10 39.9 2.3 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EDK38026.1 - 0.0068 16.8 11.7 0.0068 16.8 11.7 2.8 2 1 1 3 3 3 1 Syntaxin-like protein Pox_EPC_I2-L1 PF12575.8 EDK38026.1 - 0.0087 16.3 1.6 0.24 11.7 0.1 2.8 2 0 0 2 2 2 1 Poxvirus entry protein complex L1 and I2 Herpes_US9 PF06072.11 EDK38026.1 - 0.016 15.1 2.2 0.042 13.7 2.2 1.7 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF745 PF05335.13 EDK38026.1 - 0.019 14.7 1.6 0.019 14.7 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF948 PF06103.11 EDK38026.1 - 0.042 14.1 8.0 0.75 10.1 0.7 3.3 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) L1R_F9L PF02442.17 EDK38026.1 - 0.057 13.3 0.2 0.057 13.3 0.2 2.6 2 1 0 2 2 2 0 Lipid membrane protein of large eukaryotic DNA viruses EspG PF06872.11 EDK38026.1 - 0.11 11.0 3.9 0.19 10.2 3.9 1.3 1 0 0 1 1 1 0 EspG protein T6PP_N PF18572.1 EDK38026.1 - 0.17 11.7 8.0 0.16 11.9 0.3 2.8 2 1 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF4094 PF13334.6 EDK38026.1 - 1.7 9.1 8.0 2.3 8.7 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) SKA1 PF07160.12 EDK38026.1 - 5.9 6.7 18.3 0.32 10.8 1.6 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Plk4_PB2 PF18409.1 EDK38026.1 - 6 7.6 7.5 17 6.2 0.3 3.0 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 IPK PF03770.16 EDK38027.2 - 3.3e-55 187.0 0.0 4.1e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase GTP_EFTU PF00009.27 EDK38028.2 - 9.4e-44 149.3 0.0 1.9e-43 148.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDK38028.2 - 7.8e-36 122.8 0.6 2e-35 121.5 0.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDK38028.2 - 8.2e-08 32.5 0.2 2.2e-07 31.1 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK38028.2 - 0.0018 18.3 0.2 0.012 15.7 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase BAF1_ABF1 PF04684.13 EDK38028.2 - 1.8 7.5 12.7 3.1 6.7 12.7 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor eIF3_subunit PF08597.10 EDK38028.2 - 2.5 8.0 22.9 0.071 13.0 16.4 1.7 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Glyco_transf_15 PF01793.16 EDK38029.2 - 2.2e-55 188.2 9.9 3e-55 187.7 9.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF3867 PF12983.7 EDK38029.2 - 0.047 13.7 1.4 1.2 9.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3867) VHS PF00790.19 EDK38030.2 - 1.4e-11 44.4 0.0 3e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EDK38030.2 - 0.0038 17.5 0.9 0.012 15.9 0.1 2.3 2 1 0 2 2 2 1 GAT domain SesA PF17107.5 EDK38030.2 - 0.094 12.9 0.0 0.33 11.2 0.0 1.9 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TC1 PF15063.6 EDK38030.2 - 0.11 12.3 0.3 0.43 10.5 0.1 2.1 2 0 0 2 2 2 0 Thyroid cancer protein 1 V_ATPase_I PF01496.19 EDK38031.2 - 0.29 9.0 11.9 0.45 8.4 11.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Use1 PF09753.9 EDK38032.2 - 0.0062 16.3 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 ParA PF10609.9 EDK38033.2 - 4.1e-94 314.6 0.0 4.6e-94 314.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDK38033.2 - 1.8e-09 37.7 0.0 7.2e-09 35.8 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EDK38033.2 - 4.8e-07 29.3 0.0 5.3e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EDK38033.2 - 8.8e-06 25.7 0.3 5.6e-05 23.1 0.3 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EDK38033.2 - 5.1e-05 22.6 0.3 0.00034 19.9 0.1 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase MeaB PF03308.16 EDK38033.2 - 0.0024 16.9 0.2 0.0041 16.1 0.2 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 EDK38033.2 - 0.024 14.1 0.0 0.04 13.4 0.0 1.3 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 EDK38033.2 - 0.044 13.6 0.4 6.5 6.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDK38033.2 - 0.052 13.3 0.1 1.1 8.9 0.1 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein APS_kinase PF01583.20 EDK38033.2 - 0.08 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_25 PF13481.6 EDK38033.2 - 0.088 12.4 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 EDK38033.2 - 0.11 11.9 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 EDK38033.2 - 0.2 12.0 0.1 0.38 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain Nop16 PF09420.10 EDK38034.2 - 1.1e-62 211.8 17.4 1.5e-62 211.4 17.4 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Occludin_ELL PF07303.13 EDK38034.2 - 1.1 10.0 8.5 0.21 12.3 4.8 1.8 2 0 0 2 2 2 0 Occludin homology domain RRM_1 PF00076.22 EDK38035.1 - 2.8e-19 68.7 0.1 4.1e-19 68.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK38035.1 - 0.014 15.0 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK38035.1 - 0.023 14.5 0.0 0.11 12.3 0.0 1.9 1 1 1 2 2 2 0 Occluded RNA-recognition motif SET_assoc PF11767.8 EDK38035.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated PMI_typeI PF01238.21 EDK38036.2 - 1.9e-153 511.1 0.0 2.2e-153 510.9 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EDK38036.2 - 0.002 18.0 0.0 0.098 12.6 0.0 2.5 3 0 0 3 3 3 1 AraC-like ligand binding domain Cupin_2 PF07883.11 EDK38036.2 - 0.0034 17.1 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Thioredoxin PF00085.20 EDK38037.2 - 1.5e-19 69.9 1.7 5.1e-16 58.5 0.1 3.9 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EDK38037.2 - 5.8e-05 23.1 2.9 0.00024 21.1 0.4 3.0 2 1 1 3 3 3 1 Thioredoxin-like domain Tox-HNH-HHH PF15637.6 EDK38037.2 - 0.042 14.0 0.1 4.3 7.5 0.1 2.9 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif DUF4594 PF15266.6 EDK38037.2 - 8.5 6.7 14.9 18 5.6 14.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4594) Mito_carr PF00153.27 EDK38038.2 - 2.1e-71 235.9 3.4 8.7e-25 86.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Aa_trans PF01490.18 EDK38039.2 - 1.1e-28 100.0 29.5 1.1e-28 100.0 29.5 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDK38039.2 - 0.00018 20.7 15.5 0.00018 20.7 15.5 2.4 1 1 1 3 3 3 1 Tryptophan/tyrosine permease family Na_Pi_cotrans PF02690.15 EDK38039.2 - 0.0034 17.5 0.9 0.0034 17.5 0.9 2.9 2 1 1 3 3 3 1 Na+/Pi-cotransporter NAD_binding_10 PF13460.6 EDK38040.1 - 2.3e-10 40.7 0.0 3.3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK38040.1 - 8.6e-08 31.9 0.0 5.6e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDK38040.1 - 3.4e-05 23.5 0.0 6.8e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 EDK38040.1 - 0.0054 17.2 0.0 0.01 16.3 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDK38040.1 - 0.0074 15.3 0.1 0.064 12.3 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDK38040.1 - 0.044 12.9 0.0 0.21 10.6 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain F420_oxidored PF03807.17 EDK38040.1 - 0.052 14.1 0.0 0.097 13.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EDK38040.1 - 0.062 12.9 0.0 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GDP_Man_Dehyd PF16363.5 EDK38040.1 - 0.067 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase UDPG_MGDP_dh_N PF03721.14 EDK38040.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DapB_N PF01113.20 EDK38040.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF866 PF05907.13 EDK38041.1 - 2e-58 196.7 1.1 2.3e-58 196.5 1.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Ribosomal_L44 PF00935.19 EDK38041.1 - 0.013 15.9 1.6 1.6 9.3 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein L44 Zn_ribbon_SprT PF17283.2 EDK38041.1 - 0.016 15.1 3.1 0.046 13.6 3.1 1.7 1 1 0 1 1 1 0 SprT-like zinc ribbon domain SusF_SusE PF16411.5 EDK38041.1 - 0.016 15.7 0.1 0.022 15.3 0.1 1.2 1 0 0 1 1 1 0 Outer membrane protein SusF_SusE zf-RRPl_C4 PF17026.5 EDK38041.1 - 0.027 14.6 0.3 0.043 13.9 0.3 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Zn-ribbon_8 PF09723.10 EDK38041.1 - 0.039 14.1 0.3 1.5 9.0 0.0 2.4 2 0 0 2 2 2 0 Zinc ribbon domain RNHCP PF12647.7 EDK38041.1 - 0.081 12.9 1.7 0.99 9.4 0.1 2.2 1 1 1 2 2 2 0 RNHCP domain Cytochrom_c3_2 PF14537.6 EDK38041.1 - 0.092 13.2 3.6 1.5 9.3 0.1 2.1 1 1 1 2 2 2 0 Cytochrome c3 Zn_Tnp_IS1595 PF12760.7 EDK38041.1 - 0.23 11.5 4.5 0.58 10.2 4.5 1.7 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Peptidase_C98 PF15499.6 EDK38041.1 - 0.91 8.9 3.6 0.25 10.8 0.5 1.6 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase zf-DNL PF05180.12 EDK38041.1 - 2.3 8.2 7.4 40 4.3 7.4 2.4 1 1 0 1 1 1 0 DNL zinc finger Mito_carr PF00153.27 EDK38042.2 - 6.5e-41 138.2 5.3 8.1e-15 54.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ArfGap PF01412.18 EDK38043.2 - 3.7e-40 136.7 3.0 3.7e-40 136.7 3.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SWI-SNF_Ssr4 PF08549.10 EDK38043.2 - 0.89 8.1 9.8 1.3 7.6 9.8 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Cyt-b5 PF00173.28 EDK38044.2 - 4.7e-20 71.5 0.1 7.4e-20 70.9 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rsa3 PF14615.6 EDK38045.2 - 1.2e-18 66.4 1.0 1.2e-18 66.4 1.0 1.7 2 0 0 2 2 2 1 Ribosome-assembly protein 3 IMUP PF15761.5 EDK38045.2 - 0.023 15.4 5.6 0.048 14.3 5.6 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF755 PF05501.11 EDK38045.2 - 0.35 11.2 12.9 0.74 10.1 12.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) PBP1_TM PF14812.6 EDK38045.2 - 0.82 10.1 6.3 1.9 8.9 6.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SR-25 PF10500.9 EDK38045.2 - 1.5 8.4 16.0 2 8.0 15.5 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SUFU_C PF12470.8 EDK38045.2 - 4 7.4 6.6 3.4 7.7 5.5 1.5 1 1 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain RP-C_C PF11800.8 EDK38045.2 - 9.9 6.2 10.3 11 6.0 9.9 1.3 1 1 0 1 1 1 0 Replication protein C C-terminal region SHNi-TPR PF10516.9 EDK38046.2 - 9.2e-19 66.6 1.7 9.2e-19 66.6 1.7 2.3 2 0 0 2 2 2 1 SHNi-TPR TPR_2 PF07719.17 EDK38046.2 - 0.00024 21.0 6.2 0.086 13.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38046.2 - 0.0051 17.1 5.7 0.17 12.2 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK38046.2 - 0.099 12.5 2.8 2.9 7.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDK38046.2 - 0.2 11.5 2.7 1.1 9.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDK38046.2 - 0.43 10.3 7.3 4.9 6.9 3.9 3.2 2 1 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 EDK38046.2 - 0.57 10.3 5.1 7.1 6.9 0.2 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK38046.2 - 3.2 8.5 7.7 5.6 7.7 1.9 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TMF_TATA_bd PF12325.8 EDK38046.2 - 5.9 7.1 14.3 9.3 6.5 5.5 3.3 2 2 0 3 3 3 0 TATA element modulatory factor 1 TATA binding CNH PF00780.22 EDK38047.2 - 2.8e-30 105.9 0.4 3.8e-29 102.2 0.2 2.7 2 2 0 2 2 2 1 CNH domain PH_5 PF15405.6 EDK38047.2 - 1.8e-08 34.6 0.0 5.4e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDK38047.2 - 0.021 15.3 0.1 0.072 13.6 0.1 2.1 1 0 0 1 1 1 0 PH domain AdoMetDC_leader PF08132.11 EDK38047.2 - 0.38 10.7 2.2 17 5.4 0.1 3.0 2 0 0 2 2 2 0 S-adenosyl-l-methionine decarboxylase leader peptide adh_short_C2 PF13561.6 EDK38048.1 - 1e-43 149.6 0.0 1.2e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK38048.1 - 1.8e-40 138.5 0.2 2.3e-40 138.2 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK38048.1 - 5.3e-15 55.8 0.1 8.3e-15 55.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDK38048.1 - 0.00041 19.6 0.1 0.00056 19.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDK38048.1 - 0.0011 18.4 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDK38048.1 - 0.0017 17.8 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 EDK38048.1 - 0.037 13.4 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) EF-hand_1 PF00036.32 EDK38049.2 - 4.3e-27 91.6 17.0 1.7e-06 27.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDK38049.2 - 3.6e-22 78.6 8.3 1.5e-11 44.6 3.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDK38049.2 - 2.1e-21 74.0 12.7 2.5e-05 23.9 0.0 4.6 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EDK38049.2 - 4.6e-18 63.8 18.8 3.4e-05 23.1 0.2 4.7 4 1 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EDK38049.2 - 4.8e-10 39.1 20.4 0.0029 17.4 1.0 4.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EDK38049.2 - 1.8e-05 24.7 10.3 0.092 12.7 0.6 3.9 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EDK38049.2 - 2.5e-05 24.5 0.1 0.15 12.4 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EDK38049.2 - 0.0016 18.8 0.3 8.7 6.8 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain Sigma54_CBD PF04963.13 EDK38049.2 - 0.011 15.7 0.1 1.2 9.0 0.0 2.6 1 1 1 3 3 3 0 Sigma-54 factor, core binding domain Spc7 PF08317.11 EDK38050.2 - 0.0051 15.7 8.6 0.01 14.8 8.6 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein RNase_P_Rpp14 PF01900.19 EDK38050.2 - 0.01 16.1 0.2 0.049 13.9 0.1 2.2 2 0 0 2 2 2 0 Rpp14/Pop5 family DUF724 PF05266.14 EDK38050.2 - 0.29 10.9 12.2 0.11 12.3 6.2 3.0 2 2 2 4 4 4 0 Protein of unknown function (DUF724) DivIC PF04977.15 EDK38050.2 - 4.5 7.1 5.2 0.96 9.3 0.9 2.1 2 1 0 2 2 2 0 Septum formation initiator AAA_11 PF13086.6 EDK38051.2 - 2.5e-72 243.8 2.2 2.5e-72 243.8 2.2 2.5 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EDK38051.2 - 1.7e-64 217.1 2.3 1.7e-64 217.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain SEN1_N PF12726.7 EDK38051.2 - 1.3e-49 169.1 0.6 1.3e-49 169.1 0.6 2.1 2 0 0 2 2 2 1 SEN1 N terminal AAA_30 PF13604.6 EDK38051.2 - 6.2e-08 32.6 0.3 8.8e-05 22.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain UvrD-helicase PF00580.21 EDK38051.2 - 6.9e-08 32.4 3.7 3.6e-07 30.0 0.0 3.2 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EDK38051.2 - 6e-07 29.9 0.0 3.3e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDK38051.2 - 9.7e-06 25.5 0.3 0.19 11.4 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF4164 PF13747.6 EDK38051.2 - 5.5 7.3 12.8 2.5 8.5 9.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Fungal_trans_2 PF11951.8 EDK38052.2 - 8.2e-43 146.7 0.4 8.2e-43 146.7 0.4 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK38052.2 - 1.8e-09 37.5 11.5 3.4e-09 36.7 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4796 PF16044.5 EDK38052.2 - 0.034 13.7 1.1 0.071 12.7 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) IBR PF01485.21 EDK38053.2 - 1.8e-15 56.9 38.0 1.7e-10 41.0 7.5 3.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EDK38053.2 - 1.6e-14 54.2 1.0 3.8e-14 52.9 1.0 1.7 1 0 0 1 1 1 1 RWD domain zf-C3HC4 PF00097.25 EDK38053.2 - 9.3e-05 22.2 7.6 9.3e-05 22.2 7.6 4.3 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK38053.2 - 0.0043 17.4 9.3 0.0043 17.4 9.3 4.0 3 0 0 3 3 3 1 Ring finger domain COPIIcoated_ERV PF07970.12 EDK38054.2 - 1.1e-39 136.6 0.1 1.9e-39 135.8 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDK38054.2 - 6.2e-25 87.4 0.2 1.4e-24 86.3 0.2 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pex24p PF06398.11 EDK38055.2 - 6.9e-110 367.5 1.5 8.6e-110 367.2 1.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Pkinase PF00069.25 EDK38056.2 - 3.1e-50 171.0 0.4 9.5e-50 169.4 0.4 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38056.2 - 1.2e-25 90.3 0.1 2.5e-25 89.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 EDK38056.2 - 0.036 13.7 0.1 0.15 11.6 0.1 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase ABC_membrane_2 PF06472.15 EDK38058.2 - 1.2e-62 211.8 0.1 1.6e-62 211.4 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDK38058.2 - 3.4e-20 72.9 0.0 6.4e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDK38058.2 - 0.0021 17.9 0.1 0.007 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDK38058.2 - 0.0037 17.0 0.0 0.0091 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EDK38058.2 - 0.0048 17.4 0.7 0.022 15.3 0.0 2.4 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EDK38058.2 - 0.019 15.2 0.2 0.087 13.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.19 EDK38058.2 - 0.063 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 EDK38058.2 - 0.069 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDK38058.2 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 EDK38058.2 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EDK38058.2 - 0.14 12.5 0.2 0.76 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Pept_tRNA_hydro PF01195.19 EDK38059.1 - 1.8e-44 151.7 0.2 2.1e-44 151.5 0.2 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase CoA_binding_2 PF13380.6 EDK38060.2 - 1.2e-30 106.4 0.0 1.4e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Zn_clus PF00172.18 EDK38061.2 - 2.5e-05 24.3 9.4 4.7e-05 23.4 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK38061.2 - 9.5e-05 21.5 0.6 9.5e-05 21.5 0.6 2.6 3 0 0 3 3 3 1 Fungal specific transcription factor domain RNaseH_like PF04308.12 EDK38061.2 - 0.19 11.7 0.3 0.5 10.3 0.3 1.7 1 0 0 1 1 1 0 Ribonuclease H-like DUF4407 PF14362.6 EDK38061.2 - 3.1 7.1 6.6 0.24 10.7 1.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SH3_1 PF00018.28 EDK38062.2 - 9.8e-16 57.1 1.1 1.5e-15 56.5 0.2 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDK38062.2 - 2.6e-12 46.4 0.1 4.6e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK38062.2 - 3.6e-11 42.6 0.2 9.3e-11 41.3 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain BAR PF03114.18 EDK38062.2 - 7.3e-07 29.1 12.8 1.1e-06 28.4 12.8 1.3 1 0 0 1 1 1 1 BAR domain FapA PF03961.13 EDK38062.2 - 6.5 5.2 9.3 1.4 7.4 4.3 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A LRR_8 PF13855.6 EDK38063.2 - 5.2e-10 38.9 11.5 1.9e-07 30.8 1.9 2.5 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EDK38063.2 - 1.5e-05 25.2 9.8 1.8e-05 25.0 1.9 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) OB_NTP_bind PF07717.16 EDK38064.2 - 5.1e-20 71.6 0.0 1.8e-19 69.9 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EDK38064.2 - 6.8e-17 61.7 0.0 6.8e-17 61.7 0.0 2.7 3 1 0 3 3 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK38064.2 - 2.3e-14 53.7 0.0 7.2e-14 52.1 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDK38064.2 - 4.1e-09 36.8 0.4 1.3e-08 35.2 0.1 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EDK38064.2 - 7.7e-08 32.3 0.1 1.7e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EDK38064.2 - 3.7e-05 23.5 0.2 7.2e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK38064.2 - 4.4e-05 23.8 0.2 9.8e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDK38064.2 - 0.0013 17.8 0.0 0.0044 16.1 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein SRP54 PF00448.22 EDK38064.2 - 0.0026 17.4 0.5 0.01 15.5 0.5 2.0 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EDK38064.2 - 0.025 14.6 0.4 0.32 11.0 0.1 2.8 2 1 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EDK38064.2 - 0.1 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDK38064.2 - 0.14 12.6 0.0 0.14 12.6 0.0 2.7 2 1 0 2 2 1 0 ABC transporter AAA_16 PF13191.6 EDK38064.2 - 0.15 12.4 0.0 0.46 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EDK38064.2 - 0.38 11.2 0.0 0.38 11.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain TruB_N PF01509.18 EDK38064.2 - 0.46 10.8 3.7 1.1 9.6 3.7 1.5 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) AAA_17 PF13207.6 EDK38064.2 - 0.56 10.6 3.7 19 5.7 0.1 3.7 4 0 0 4 4 4 0 AAA domain PRK PF00485.18 EDK38065.2 - 4.2e-61 206.1 0.0 6.1e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EDK38065.2 - 1e-35 123.1 0.0 1.8e-35 122.3 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EDK38065.2 - 7e-06 26.6 0.0 1.4e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK38065.2 - 7.1e-05 23.0 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EDK38065.2 - 0.00018 20.8 0.0 0.00032 20.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 EDK38065.2 - 0.0017 18.2 0.0 0.003 17.4 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EDK38065.2 - 0.0084 16.5 0.1 0.066 13.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain Serglycin PF04360.12 EDK38065.2 - 0.011 15.7 0.1 0.019 14.9 0.1 1.3 1 0 0 1 1 1 0 Serglycin KAP_NTPase PF07693.14 EDK38065.2 - 0.015 14.6 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_24 PF13479.6 EDK38065.2 - 0.027 14.2 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDK38065.2 - 0.042 14.1 0.0 0.091 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EDK38065.2 - 0.042 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EDK38065.2 - 0.051 13.6 0.0 0.21 11.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) CoaE PF01121.20 EDK38065.2 - 0.057 13.1 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Dephospho-CoA kinase APS_kinase PF01583.20 EDK38065.2 - 0.063 13.2 0.0 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase CbiA PF01656.23 EDK38065.2 - 0.093 12.8 0.0 0.79 9.8 0.0 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 EDK38065.2 - 0.12 12.7 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Aminotran_1_2 PF00155.21 EDK38066.2 - 1e-41 143.3 0.0 1.9e-41 142.4 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDK38066.2 - 0.085 12.1 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase UspB PF10625.9 EDK38066.2 - 0.17 11.8 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Universal stress protein B (UspB) Gaa1 PF04114.14 EDK38067.1 - 3.7e-128 428.7 8.2 4.7e-128 428.3 8.2 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component ANAPC4 PF12896.7 EDK38068.2 - 4.5e-57 192.8 5.3 8.6e-57 191.9 5.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EDK38068.2 - 7.7e-18 64.6 0.1 2.7e-16 59.6 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain TIR_3 PF18567.1 EDK38068.2 - 0.03 14.3 0.0 0.22 11.5 0.0 2.4 1 1 1 2 2 2 0 Toll/interleukin-1 receptor domain eIF2A PF08662.11 EDK38068.2 - 0.13 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DTW PF03942.15 EDK38068.2 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 DTW domain LAGLIDADG_1 PF00961.19 EDK38068.2 - 0.32 12.0 2.7 0.36 11.8 0.5 2.2 2 0 0 2 2 2 0 LAGLIDADG endonuclease Ribosomal_L1 PF00687.21 EDK38069.2 - 1.4e-25 90.3 0.0 1.9e-25 89.8 0.0 1.2 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family RhoGAP PF00620.27 EDK38070.2 - 7.7e-12 45.3 0.2 8.1e-05 22.5 0.2 2.4 2 0 0 2 2 2 2 RhoGAP domain SDA1 PF05285.12 EDK38070.2 - 1.9 7.9 14.4 3.2 7.1 14.4 1.3 1 0 0 1 1 1 0 SDA1 cNMP_binding PF00027.29 EDK38071.2 - 6.5e-35 119.1 0.0 5.8e-18 64.7 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EDK38071.2 - 5.1e-10 38.6 10.0 0.61 10.3 0.1 8.3 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.7 EDK38071.2 - 8.2e-10 38.8 8.7 0.041 14.3 0.0 6.9 7 1 0 7 7 7 3 Leucine Rich repeats (2 copies) F-box PF00646.33 EDK38071.2 - 4e-07 29.7 2.3 2.4e-05 24.1 0.4 4.1 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.7 EDK38071.2 - 1.5e-06 28.0 2.8 2.2e-06 27.4 0.3 2.6 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.33 EDK38071.2 - 0.00058 20.0 13.6 55 4.9 0.2 9.4 8 1 1 9 9 9 0 Leucine Rich Repeat SUI1 PF01253.22 EDK38072.2 - 3.9e-21 75.3 0.0 2.4e-20 72.8 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EDK38072.2 - 5.2e-05 23.9 0.2 0.00018 22.1 0.1 2.1 2 0 0 2 2 2 1 Pre-PUA-like domain SWIB PF02201.18 EDK38072.2 - 0.0025 17.7 0.1 0.0084 16.0 0.1 1.9 1 1 0 1 1 1 1 SWIB/MDM2 domain PUA PF01472.20 EDK38072.2 - 0.045 13.7 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 PUA domain PIG-S PF10510.9 EDK38073.1 - 1.2e-110 370.9 2.6 1.4e-110 370.6 2.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Endonuclease_NS PF01223.23 EDK38074.2 - 1.7e-64 217.8 0.0 1.9e-64 217.6 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF1729 PF08354.10 EDK38075.2 - 2.7e-156 519.9 0.0 4.5e-156 519.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EDK38075.2 - 2.8e-91 306.3 0.0 5.4e-90 302.1 0.0 2.7 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 EDK38075.2 - 2e-42 144.4 0.0 4.4e-42 143.3 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 EDK38075.2 - 6.7e-42 143.9 0.0 1.2e-41 143.1 0.0 1.4 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 EDK38075.2 - 6.6e-39 132.3 0.0 1.4e-38 131.2 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 EDK38075.2 - 3.8e-34 117.5 0.1 1.5e-33 115.5 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 EDK38075.2 - 6e-15 55.6 0.0 1.6e-14 54.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Tic110 PF16940.5 EDK38075.2 - 0.11 10.9 0.1 0.2 10.1 0.1 1.3 1 0 0 1 1 1 0 Chloroplast envelope transporter NMO PF03060.15 EDK38075.2 - 0.16 11.3 0.8 0.95 8.8 0.2 2.4 2 1 0 2 2 2 0 Nitronate monooxygenase DUF438 PF04282.13 EDK38075.2 - 0.94 9.5 2.7 2.6 8.1 0.5 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF438) His_Phos_2 PF00328.22 EDK38076.2 - 1.4e-137 459.1 0.1 1.8e-137 458.8 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EDK38076.2 - 7e-37 125.5 0.0 2e-36 124.0 0.0 1.9 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EDK38076.2 - 2.6e-06 27.1 0.0 5.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Pribosyltran_N PF13793.6 EDK38077.2 - 2.5e-40 137.0 0.0 5.2e-40 136.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDK38077.2 - 3.4e-38 131.5 0.6 2.2e-29 102.8 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDK38077.2 - 1.6e-06 27.7 0.4 1.9e-05 24.2 0.4 2.1 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRR1 PF07985.12 EDK38078.2 - 1.1e-20 73.4 0.1 2.2e-20 72.4 0.1 1.6 1 0 0 1 1 1 1 SRR1 HSF_DNA-bind PF00447.17 EDK38079.2 - 6.5e-30 103.6 6.3 1.2e-29 102.8 6.3 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EDK38079.2 - 3.1e-27 94.9 0.4 2e-26 92.3 0.3 2.2 2 0 0 2 2 2 1 Response regulator receiver domain Ets PF00178.22 EDK38079.2 - 0.0025 18.3 0.4 0.0055 17.1 0.4 1.6 1 0 0 1 1 1 1 Ets-domain Spermine_synth PF01564.17 EDK38079.2 - 0.025 14.0 0.2 0.025 14.0 0.2 1.9 2 0 0 2 2 2 0 Spermine/spermidine synthase domain GIY-YIG PF01541.24 EDK38080.2 - 6.4e-12 45.6 0.0 9.4e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.9 EDK38080.2 - 0.036 14.6 0.0 0.081 13.5 0.0 1.8 1 1 0 1 1 1 0 T5orf172 domain Nudix_N_2 PF14803.6 EDK38080.2 - 1.5 8.8 6.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 Nudix N-terminal Glyco_hydro_31 PF01055.26 EDK38081.2 - 4.2e-137 458.0 0.7 5.7e-137 457.5 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EDK38081.2 - 1.4e-24 86.2 0.4 3.9e-22 78.3 0.1 2.7 2 0 0 2 2 2 2 Galactose mutarotase-like DUF5110 PF17137.4 EDK38081.2 - 0.018 15.3 0.4 0.084 13.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) BRE1 PF08647.11 EDK38082.2 - 4.7e-22 77.9 9.1 4.7e-22 77.9 9.1 8.0 4 2 2 7 7 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EDK38082.2 - 3.3e-07 30.1 7.1 5.4e-07 29.4 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK38082.2 - 6.1e-07 29.2 6.9 1.1e-06 28.4 6.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EDK38082.2 - 1.1e-06 28.4 8.9 2e-06 27.6 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK38082.2 - 1.7e-05 24.6 9.0 3.3e-05 23.7 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK38082.2 - 2.1e-05 24.4 9.9 3.8e-05 23.6 9.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EDK38082.2 - 5.4e-05 23.4 9.6 9.6e-05 22.6 9.6 1.4 1 0 0 1 1 1 1 Ring finger domain JIP_LZII PF16471.5 EDK38082.2 - 0.0054 16.9 3.2 0.0054 16.9 3.2 9.8 7 3 3 10 10 10 2 JNK-interacting protein leucine zipper II zf-RING_UBOX PF13445.6 EDK38082.2 - 0.0075 16.3 7.9 0.015 15.3 7.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger UPF0184 PF03670.13 EDK38082.2 - 0.019 15.3 4.9 0.019 15.3 4.9 5.6 4 2 4 8 8 7 0 Uncharacterised protein family (UPF0184) zf-C3HC4_4 PF15227.6 EDK38082.2 - 0.13 12.4 6.5 0.27 11.4 6.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 EDK38082.2 - 0.14 12.3 4.3 0.32 11.1 4.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.7 EDK38082.2 - 0.17 12.2 7.0 0.46 10.8 7.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C2H2 PF00096.26 EDK38082.2 - 0.2 12.2 0.1 0.2 12.2 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Gin PF10764.9 EDK38082.2 - 0.24 11.4 6.7 0.24 11.4 1.7 3.0 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin CENP-F_leu_zip PF10473.9 EDK38082.2 - 0.3 11.1 94.9 0.64 10.0 8.0 6.3 3 1 3 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zinc_ribbon_9 PF14369.6 EDK38082.2 - 0.58 10.5 3.9 1.8 8.9 3.9 1.9 1 1 0 1 1 1 0 zinc-ribbon zf-RING_4 PF14570.6 EDK38082.2 - 0.61 9.9 5.9 1.3 8.9 5.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2H2_4 PF13894.6 EDK38082.2 - 1.3 10.1 7.6 1.1 10.3 0.1 3.2 2 1 0 2 2 2 0 C2H2-type zinc finger DivIC PF04977.15 EDK38082.2 - 1.6 8.5 65.7 0.096 12.5 3.3 9.1 4 2 5 9 9 9 0 Septum formation initiator DZR PF12773.7 EDK38082.2 - 2.1 8.5 5.9 4.5 7.4 5.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 EDK38082.2 - 2.8 8.2 10.5 29 4.9 10.5 2.5 1 1 0 1 1 1 0 FYVE zinc finger LptF_LptG PF03739.14 EDK38082.2 - 6.6 5.5 6.9 14 4.4 6.9 1.8 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Bromodomain PF00439.25 EDK38083.1 - 2.1e-17 63.0 0.1 3.6e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 Bromodomain Dus PF01207.17 EDK38084.2 - 2.5e-80 269.9 0.0 2.9e-80 269.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EDK38084.2 - 0.00016 21.0 0.1 0.002 17.4 0.1 2.0 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 EDK38084.2 - 0.00092 18.6 0.1 0.002 17.5 0.1 1.6 1 0 0 1 1 1 1 Thiamine monophosphate synthase Resolvase PF00239.21 EDK38084.2 - 0.003 17.7 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 Resolvase, N terminal domain OST_P2 PF18235.1 EDK38084.2 - 0.013 15.4 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Oligosaccharyltransferase Peripheral 2 domain Myb_DNA-bind_7 PF15963.5 EDK38084.2 - 0.015 15.1 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 Myb DNA-binding like Oxidored_FMN PF00724.20 EDK38084.2 - 0.031 13.5 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family His_biosynth PF00977.21 EDK38084.2 - 0.073 12.5 0.1 0.33 10.4 0.1 2.1 2 1 0 2 2 2 0 Histidine biosynthesis protein SMC_N PF02463.19 EDK38085.1 - 7e-37 127.0 0.0 7.1e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK38085.1 - 2.1e-06 27.8 0.0 2.5e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EDK38085.1 - 0.023 14.9 0.1 0.045 14.0 0.1 1.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EDK38086.2 - 4.2e-29 101.6 36.8 4.2e-29 101.6 36.8 3.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDK38086.2 - 1.4e-20 73.8 0.1 1e-19 70.9 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDK38086.2 - 1.5e-08 35.4 28.7 1.5e-08 35.4 28.7 7.8 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.6 EDK38086.2 - 6.5e-06 26.2 0.1 6.5e-06 26.2 0.1 3.0 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDK38086.2 - 5.3e-05 23.1 40.5 5.3e-05 23.1 40.5 5.4 3 2 1 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 EDK38086.2 - 8.2e-05 22.3 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain L27_1 PF09058.10 EDK38086.2 - 0.38 10.8 10.0 0.55 10.3 1.4 4.7 3 0 0 3 3 3 0 L27_1 Spc7 PF08317.11 EDK38086.2 - 3.9 6.3 139.6 0.044 12.7 26.3 7.3 2 2 6 8 8 8 0 Spc7 kinetochore protein DUF2533 PF10752.9 EDK38086.2 - 7.9 7.0 11.6 39 4.8 5.6 4.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2533) RNA_polI_A14 PF08203.11 EDK38087.2 - 3e-22 79.1 0.0 3e-22 79.1 0.0 2.6 2 1 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 CDC45 PF02724.14 EDK38087.2 - 0.039 12.3 31.6 0.042 12.1 31.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Opi1 PF08618.10 EDK38087.2 - 0.13 11.5 8.5 0.19 11.0 8.5 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 VIR_N PF15912.5 EDK38087.2 - 1.4 8.4 21.3 1.9 8.0 21.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal GAGA_bind PF06217.12 EDK38087.2 - 2.5 8.3 21.0 3.1 8.0 21.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Ribosomal_L34 PF00468.17 EDK38088.2 - 5.1e-22 77.6 7.2 5.1e-22 77.6 7.2 1.5 1 1 0 1 1 1 1 Ribosomal protein L34 DUF3580 PF12117.8 EDK38090.2 - 0.098 12.9 0.7 0.18 12.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) DnaJ_C PF01556.18 EDK38091.2 - 1.5e-34 119.3 0.3 2.1e-34 118.7 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDK38091.2 - 1.1e-25 89.5 1.3 2e-25 88.7 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDK38091.2 - 6.6e-14 52.0 15.6 1.1e-13 51.3 15.6 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDK38091.2 - 0.001 19.0 7.9 0.051 13.5 0.5 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDK38091.2 - 0.026 14.5 2.9 2.6 8.1 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1356 PF07092.12 EDK38091.2 - 0.24 10.7 2.1 1.7 7.8 0.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1356) Aldo_ket_red PF00248.21 EDK38092.2 - 8.7e-58 195.8 0.0 1.1e-57 195.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aminotran_MocR PF12897.7 EDK38092.2 - 0.15 10.8 0.0 0.54 9.0 0.0 1.8 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase HTH_Tnp_Tc5 PF03221.16 EDK38093.2 - 3.5e-14 52.6 0.0 9.8e-14 51.1 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EDK38093.2 - 5.9e-05 22.6 0.1 0.00013 21.5 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF4817 PF16087.5 EDK38093.2 - 0.0053 16.5 0.1 0.021 14.6 0.1 2.2 1 1 0 1 1 1 1 Helix-turn-helix domain (DUF4817) NYD-SP28 PF14772.6 EDK38094.2 - 0.00056 19.9 1.7 0.0019 18.2 1.0 2.3 1 1 0 1 1 1 1 Sperm tail BAR_3_WASP_bdg PF10456.9 EDK38094.2 - 0.013 15.0 0.4 0.03 13.8 0.4 1.6 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein Scaffolding_pro PF11418.8 EDK38094.2 - 0.044 14.3 0.4 0.044 14.3 0.4 2.9 3 0 0 3 3 3 0 Phi29 scaffolding protein DUF4407 PF14362.6 EDK38094.2 - 0.67 9.2 6.5 1.2 8.4 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EDK38094.2 - 3.2 7.6 9.9 7.9 6.3 0.0 4.2 3 1 1 4 4 4 0 Septum formation initiator TLE_N PF03920.15 EDK38094.2 - 3.4 7.8 6.6 11 6.1 0.2 3.2 3 1 0 3 3 3 0 Groucho/TLE N-terminal Q-rich domain DUF3450 PF11932.8 EDK38094.2 - 9.8 5.4 14.7 0.61 9.4 5.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Allantoicase PF03561.15 EDK38095.2 - 6.5e-94 311.5 0.2 1.5e-48 164.4 0.0 2.0 2 0 0 2 2 2 2 Allantoicase repeat DUF512 PF04459.12 EDK38095.2 - 0.2 10.9 0.0 0.35 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Methyltransf_16 PF10294.9 EDK38096.2 - 9.8e-18 64.5 0.2 1.8e-17 63.6 0.2 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EDK38096.2 - 0.00012 21.6 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDK38096.2 - 0.0015 19.2 0.0 0.0026 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EDK38096.2 - 0.0045 16.9 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK38096.2 - 0.0056 16.5 0.0 0.0076 16.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK38096.2 - 0.0076 17.0 0.0 0.014 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDK38096.2 - 0.019 14.4 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDK38096.2 - 0.043 13.6 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AA_permease PF00324.21 EDK38097.2 - 3.7e-122 408.4 45.7 4.6e-122 408.0 45.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK38097.2 - 4.5e-36 124.6 46.5 5.7e-36 124.3 46.5 1.1 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.16 EDK38098.2 - 1.7e-36 125.9 59.5 1.7e-32 112.7 59.9 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EDK38098.2 - 0.44 10.3 3.1 0.98 9.2 3.1 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SAGA-Tad1 PF12767.7 EDK38099.2 - 7e-28 98.0 0.4 7.8e-28 97.8 0.4 1.0 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit SAGA-Tad1 PF12767.7 EDK38100.1 - 5.6e-12 45.9 0.0 1.1e-11 44.9 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 EDK38100.1 - 0.013 15.3 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Fez1 PF06818.15 EDK38101.2 - 5.3e-05 23.8 41.3 0.00059 20.4 14.4 3.1 1 1 1 2 2 2 2 Fez1 Prominin PF05478.11 EDK38101.2 - 0.00027 19.1 26.1 0.017 13.1 8.0 2.2 1 1 1 2 2 2 2 Prominin FlaC_arch PF05377.11 EDK38101.2 - 0.00036 20.9 2.7 0.00036 20.9 2.7 4.7 4 2 1 5 5 5 1 Flagella accessory protein C (FlaC) DivIC PF04977.15 EDK38101.2 - 0.00078 19.2 1.5 0.00078 19.2 1.5 5.5 3 2 2 5 5 5 2 Septum formation initiator ATG16 PF08614.11 EDK38101.2 - 0.0054 17.0 46.6 0.12 12.6 24.2 2.6 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) BRE1 PF08647.11 EDK38101.2 - 0.009 16.1 10.9 0.009 16.1 10.9 4.6 1 1 0 3 3 3 1 BRE1 E3 ubiquitin ligase DUF1075 PF06388.11 EDK38101.2 - 0.16 12.0 4.0 0.06 13.4 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1075) ATP-synt_ab_N PF02874.23 EDK38101.2 - 0.18 12.3 0.6 2.4 8.8 0.1 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain DUF1664 PF07889.12 EDK38101.2 - 0.57 10.2 22.2 0.12 12.4 2.6 3.7 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EDK38101.2 - 0.62 10.3 36.0 0.2 11.9 13.5 3.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain IFT57 PF10498.9 EDK38101.2 - 0.87 8.5 38.1 11 4.8 21.7 2.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 PI_PP_I PF18363.1 EDK38101.2 - 1.3 9.2 11.8 0.55 10.4 1.0 3.8 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain DUF812 PF05667.11 EDK38101.2 - 1.3 7.8 47.1 1.2 7.9 12.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) FPP PF05911.11 EDK38101.2 - 1.4 7.0 42.1 1.8 6.7 6.8 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Jnk-SapK_ap_N PF09744.9 EDK38101.2 - 1.8 8.7 45.6 0.026 14.8 17.9 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 FlxA PF14282.6 EDK38101.2 - 2.3 8.2 30.2 0.34 10.9 5.5 3.3 2 1 1 3 3 3 0 FlxA-like protein APG6_N PF17675.1 EDK38101.2 - 3.1 8.3 52.6 0.87 10.1 16.8 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region Atg14 PF10186.9 EDK38101.2 - 3.1 6.8 34.4 0.95 8.5 16.9 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TACC_C PF05010.14 EDK38101.2 - 4.6 7.0 42.5 14 5.4 29.3 2.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Osmo_CC PF08946.10 EDK38101.2 - 7.7 6.9 10.8 6.4 7.1 0.0 4.2 3 1 0 3 3 3 0 Osmosensory transporter coiled coil THOC7 PF05615.13 EDK38101.2 - 9.3 6.5 39.4 2.3 8.5 3.9 3.6 1 1 1 3 3 3 0 Tho complex subunit 7 V-SNARE_C PF12352.8 EDK38102.2 - 3.3e-18 65.7 2.2 3.3e-18 65.7 2.2 2.2 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 EDK38102.2 - 7.7e-09 35.8 2.3 7.7e-09 35.8 2.3 2.3 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus DUF4407 PF14362.6 EDK38102.2 - 0.00071 19.0 2.1 0.00083 18.8 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Use1 PF09753.9 EDK38102.2 - 0.001 18.8 2.5 0.0016 18.2 2.5 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Sec20 PF03908.13 EDK38102.2 - 0.0011 18.8 0.3 0.0011 18.8 0.3 2.0 1 1 1 2 2 2 1 Sec20 STAT_alpha PF01017.20 EDK38102.2 - 0.23 11.3 7.1 0.33 10.8 7.1 1.3 1 1 0 1 1 1 0 STAT protein, all-alpha domain ThiD2 PF17792.1 EDK38102.2 - 0.55 10.7 4.8 0.83 10.1 3.8 1.7 1 1 1 2 2 2 0 ThiD2 family Fusion_gly PF00523.18 EDK38102.2 - 0.78 7.9 3.8 0.16 10.2 0.3 1.5 2 1 0 2 2 2 0 Fusion glycoprotein F0 Glyco_hydro_63 PF03200.16 EDK38103.2 - 5.3e-09 35.4 5.4 1.1e-05 24.5 0.1 4.3 4 1 0 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain F-box-like PF12937.7 EDK38104.2 - 9.8e-05 22.2 0.0 0.00041 20.2 0.0 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EDK38104.2 - 0.035 14.0 0.0 0.11 12.4 0.0 1.9 1 0 0 1 1 1 0 F-box domain zf-C2H2_aberr PF17017.5 EDK38105.2 - 6.1e-06 26.5 1.5 0.018 15.2 0.2 2.6 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 EDK38105.2 - 9.2e-05 22.7 19.0 0.02 15.4 1.0 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK38105.2 - 0.0026 18.5 21.5 0.034 15.0 0.5 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK38105.2 - 0.051 14.0 0.6 0.051 14.0 0.6 3.7 4 0 0 4 4 4 0 Zinc-finger double domain zf-met PF12874.7 EDK38105.2 - 0.076 13.4 1.1 1.8 9.1 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK38105.2 - 7.7 6.9 15.1 1.7 9.1 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Seipin PF06775.14 EDK38106.2 - 1.1e-14 55.1 5.0 4.9e-14 52.9 5.0 1.8 1 1 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF1765 PF08578.10 EDK38107.2 - 2.2e-37 128.3 7.0 3.1e-37 127.8 5.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) Phage_Coat_B PF05356.11 EDK38107.2 - 0.16 11.9 0.0 0.49 10.3 0.0 1.8 1 0 0 1 1 1 0 Phage Coat protein B AA_permease_C PF13906.6 EDK38107.2 - 0.62 10.2 3.0 8.1 6.6 0.4 2.8 2 0 0 2 2 2 0 C-terminus of AA_permease Choline_kinase PF01633.20 EDK38108.2 - 1.7e-54 184.6 0.2 2.6e-54 184.0 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EDK38108.2 - 6.5e-12 45.0 0.2 1.5e-11 43.7 0.2 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EDK38108.2 - 1.1e-05 25.5 0.9 2.5e-05 24.3 0.9 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Phage_tail_L PF05100.12 EDK38108.2 - 0.05 12.9 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Phage minor tail protein L WD40 PF00400.32 EDK38109.2 - 2e-17 63.2 19.7 0.00098 19.9 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38109.2 - 0.022 15.1 0.8 1.4 9.3 0.1 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain KH_1 PF00013.29 EDK38110.2 - 7.2e-18 64.2 3.9 3.4e-07 30.0 0.1 5.8 8 0 0 8 8 8 3 KH domain DUF4974 PF16344.5 EDK38110.2 - 0.0054 16.7 11.0 0.61 10.1 1.0 4.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4974) FSA_C PF10479.9 EDK38110.2 - 0.043 12.0 0.1 0.043 12.0 0.1 1.5 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus DUF5093 PF17011.5 EDK38110.2 - 1.2 9.4 5.7 0.58 10.4 0.1 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF5093) ELO PF01151.18 EDK38111.2 - 1.7e-74 250.5 12.0 2e-74 250.3 12.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Sugar_tr PF00083.24 EDK38112.2 - 6.9e-99 331.7 16.4 8.5e-99 331.4 16.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK38112.2 - 3.8e-35 121.5 42.6 8.7e-31 107.1 19.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDK38112.2 - 0.0053 15.7 8.8 0.71 8.7 8.8 2.3 1 1 0 1 1 1 1 MFS_1 like family OATP PF03137.20 EDK38112.2 - 0.077 11.3 13.3 0.0063 14.9 3.6 2.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Ribosomal_L7Ae PF01248.26 EDK38114.1 - 7e-23 80.2 0.6 1.2e-22 79.4 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDK38114.1 - 0.0034 17.4 0.1 0.0055 16.8 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 EF-hand_like PF09279.11 EDK38114.1 - 0.091 13.3 0.2 0.42 11.1 0.1 2.0 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like RRM_1 PF00076.22 EDK38115.2 - 1.1e-25 89.2 6.1 2.6e-15 56.0 0.7 3.7 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK38115.2 - 8.5e-07 29.0 0.3 0.001 19.1 0.1 2.9 2 1 1 3 3 3 2 RNA recognition motif Limkain-b1 PF11608.8 EDK38115.2 - 0.0016 18.4 0.8 2.8 8.1 0.0 3.2 2 1 0 2 2 2 2 Limkain b1 DbpA PF03880.15 EDK38115.2 - 0.058 13.4 0.6 7.5 6.6 0.2 2.5 2 0 0 2 2 2 0 DbpA RNA binding domain BRAP2 PF07576.12 EDK38115.2 - 0.12 12.6 1.0 0.82 9.9 0.1 2.2 2 0 0 2 2 2 0 BRCA1-associated protein 2 PHM7_cyt PF14703.6 EDK38115.2 - 0.21 11.8 0.2 0.21 11.8 0.2 4.0 2 2 2 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter GREB1 PF15782.5 EDK38115.2 - 0.58 7.2 8.0 0.76 6.8 8.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4551 PF15087.6 EDK38115.2 - 1.5 7.6 8.0 2 7.1 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) ABC_membrane PF00664.23 EDK38116.2 - 1.7e-14 54.2 1.7 1.7e-14 54.2 1.7 2.3 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDK38117.2 - 3.1e-59 199.4 0.0 3.5e-35 121.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDK38117.2 - 4.8e-33 115.0 13.6 8.8e-33 114.1 13.0 1.6 1 1 1 2 2 2 1 ABC transporter transmembrane region AAA_23 PF13476.6 EDK38117.2 - 4.2e-10 40.5 4.5 9.5e-05 23.0 0.2 2.7 3 0 0 3 3 2 2 AAA domain SMC_N PF02463.19 EDK38117.2 - 2.4e-09 37.0 5.0 0.028 13.8 2.3 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDK38117.2 - 2.1e-08 33.8 0.2 0.00094 18.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDK38117.2 - 2.2e-08 34.3 1.7 0.0013 18.6 0.0 3.4 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDK38117.2 - 1.8e-07 31.2 2.1 0.0072 16.1 0.3 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EDK38117.2 - 5.4e-06 26.3 0.0 0.0015 18.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDK38117.2 - 6.5e-06 26.5 1.0 0.12 12.6 0.1 3.2 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDK38117.2 - 8.1e-06 25.8 0.0 0.031 14.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK38117.2 - 1.2e-05 25.8 0.1 0.054 13.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EDK38117.2 - 2.7e-05 24.2 0.1 0.047 13.8 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 EDK38117.2 - 0.0012 19.2 0.2 2.5 8.6 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDK38117.2 - 0.0013 18.3 0.1 0.38 10.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region T2SSE PF00437.20 EDK38117.2 - 0.0019 17.3 0.3 0.15 11.1 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein Roc PF08477.13 EDK38117.2 - 0.0028 17.9 0.4 2.6 8.3 0.1 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EDK38117.2 - 0.0035 17.5 0.1 0.64 10.1 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain Zeta_toxin PF06414.12 EDK38117.2 - 0.0047 16.2 0.0 0.79 9.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 EDK38117.2 - 0.0065 16.5 0.9 0.78 9.8 0.1 2.8 3 0 0 3 3 2 1 Dynamin family AAA_30 PF13604.6 EDK38117.2 - 0.0074 16.0 0.3 5.6 6.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK38117.2 - 0.012 15.0 0.0 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_25 PF13481.6 EDK38117.2 - 0.02 14.4 0.0 0.48 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EDK38117.2 - 0.027 14.5 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.17 EDK38117.2 - 0.034 13.9 0.3 31 4.3 0.0 3.5 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 EDK38117.2 - 0.047 13.7 0.0 15 5.6 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EDK38117.2 - 0.053 12.7 0.0 0.65 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 EDK38117.2 - 0.055 13.1 2.4 0.58 9.7 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 EDK38117.2 - 0.064 13.0 0.1 6.6 6.4 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Pox_A32 PF04665.12 EDK38117.2 - 0.078 12.4 0.1 0.91 8.9 0.1 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_14 PF13173.6 EDK38117.2 - 0.091 12.8 0.2 29 4.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.9 EDK38117.2 - 0.093 11.6 0.0 3.7 6.4 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.15 EDK38117.2 - 0.1 11.4 0.2 0.88 8.3 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_11 PF13086.6 EDK38117.2 - 0.11 12.3 0.1 0.46 10.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EDK38117.2 - 0.11 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 EDK38117.2 - 0.16 11.9 0.3 2.4 8.0 0.0 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea DUF2244 PF10003.9 EDK38117.2 - 6.1 6.5 6.9 5.8 6.6 0.3 3.3 4 0 0 4 4 3 0 Integral membrane protein (DUF2244) AA_permease_2 PF13520.6 EDK38118.2 - 4.3e-66 223.5 37.0 5.5e-66 223.2 37.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK38118.2 - 3.4e-12 45.7 34.4 4.9e-12 45.2 34.4 1.3 1 1 0 1 1 1 1 Amino acid permease Asp PF00026.23 EDK38120.2 - 6.7e-59 199.9 0.4 8.1e-59 199.6 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK38120.2 - 7.2e-13 49.2 0.3 1.3e-06 28.7 0.1 3.2 2 1 0 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDK38120.2 - 4.6e-05 24.0 0.0 0.19 12.4 0.0 3.0 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EDK38120.2 - 0.0032 18.0 0.0 2 9.0 0.0 3.0 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDK38120.2 - 0.0041 16.9 0.1 0.33 10.7 0.0 2.8 3 0 0 3 3 3 1 Xylanase inhibitor C-terminal CLTH PF10607.9 EDK38122.2 - 4.1e-31 107.9 0.8 6.3e-31 107.3 0.8 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EDK38122.2 - 1.6e-07 31.0 0.2 4.3e-07 29.7 0.2 1.8 1 0 0 1 1 1 1 LisH BACK PF07707.15 EDK38122.2 - 0.068 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch PCP_red PF08369.10 EDK38122.2 - 0.1 12.8 0.0 0.59 10.4 0.0 2.2 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit GATA PF00320.27 EDK38123.2 - 2.7e-07 30.1 5.9 2.7e-07 30.1 5.9 2.0 2 0 0 2 2 2 1 GATA zinc finger ADD_DNMT3 PF17980.1 EDK38123.2 - 0.15 12.1 4.2 0.068 13.2 0.8 2.1 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 DZR PF12773.7 EDK38123.2 - 1.7 8.7 5.9 31 4.7 4.8 2.5 1 1 1 2 2 2 0 Double zinc ribbon ubiquitin PF00240.23 EDK38124.2 - 3.4e-23 81.2 0.0 5.1e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDK38124.2 - 1.7e-08 34.1 0.0 2.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EDK38124.2 - 7.9e-08 32.1 0.0 7.9e-08 32.1 0.0 2.3 3 0 0 3 3 3 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 EDK38124.2 - 6.3e-05 23.0 0.1 0.00018 21.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDK38124.2 - 0.00033 21.2 0.0 0.00056 20.4 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain STI1 PF17830.1 EDK38124.2 - 0.0014 18.5 17.1 0.1 12.5 2.3 2.4 2 0 0 2 2 2 2 STI1 domain Ubiquitin_2 PF14560.6 EDK38124.2 - 0.0016 18.8 0.0 0.0041 17.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 EDK38124.2 - 0.021 14.8 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair TBK1_ULD PF18396.1 EDK38124.2 - 0.062 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDK38124.2 - 0.085 12.9 0.1 2.8 8.1 0.1 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain XPC-binding PF09280.11 EDK38124.2 - 0.7 9.7 13.3 4.4 7.1 11.1 2.4 1 1 1 2 2 2 0 XPC-binding domain GerD PF17898.1 EDK38124.2 - 1.6 8.7 12.6 4.7 7.2 12.6 1.7 1 1 0 1 1 1 0 Spore germination GerD central core domain TAF8_C PF10406.9 EDK38125.2 - 3.8e-16 59.4 1.5 3.8e-16 59.4 1.5 3.5 4 0 0 4 4 4 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EDK38125.2 - 0.00023 21.1 0.2 0.00072 19.5 0.0 1.9 2 0 0 2 2 2 1 Bromodomain associated DUF2884 PF11101.8 EDK38125.2 - 0.19 11.2 2.1 0.57 9.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Sugar_tr PF00083.24 EDK38126.2 - 2.7e-84 283.7 25.3 3.2e-84 283.4 25.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK38126.2 - 1.1e-21 77.2 24.2 9.2e-20 70.9 20.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK38126.2 - 0.00012 20.6 5.1 0.00012 20.6 5.1 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) NIF PF03031.18 EDK38128.2 - 2.7e-27 95.4 0.1 2.4e-26 92.4 0.0 2.2 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EDK38128.2 - 4.9e-07 30.0 0.1 2e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDK38128.2 - 0.00039 20.8 0.0 0.00096 19.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EDK38128.2 - 0.00074 19.4 0.1 0.0022 17.9 0.0 1.8 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 EDK38128.2 - 0.0094 16.2 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain SUR7 PF06687.12 EDK38129.2 - 1.2e-75 253.7 9.8 1.5e-75 253.5 9.8 1.0 1 0 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.6 EDK38129.2 - 0.00069 19.4 2.3 0.00069 19.4 2.3 2.0 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 EDK38129.2 - 0.0088 15.9 1.8 0.0088 15.9 1.8 2.1 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family H_PPase PF03030.16 EDK38129.2 - 0.21 10.2 3.5 1.4 7.5 1.6 2.0 2 0 0 2 2 2 0 Inorganic H+ pyrophosphatase Tetraspanin PF00335.20 EDK38129.2 - 0.68 9.6 19.7 2.9 7.5 0.5 2.8 1 1 0 2 2 2 0 Tetraspanin family SLATT_5 PF18160.1 EDK38129.2 - 6.5 6.0 7.9 16 4.8 0.2 2.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Amastin PF07344.11 EDK38129.2 - 6.7 6.5 14.2 1.8 8.4 9.0 2.5 2 1 0 2 2 2 0 Amastin surface glycoprotein Coatomer_WDAD PF04053.14 EDK38130.2 - 2.3e-08 33.5 0.5 4.5e-08 32.6 0.3 1.5 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 EDK38130.2 - 0.049 13.5 0.1 0.6 10.0 0.0 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A PGM_PMM_I PF02878.16 EDK38131.2 - 3e-35 120.9 0.5 9.5e-33 112.8 0.5 2.5 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EDK38131.2 - 1.9e-21 76.6 0.0 3.1e-20 72.7 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EDK38131.2 - 1.5e-18 67.1 0.0 2.7e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EDK38131.2 - 2.1e-06 27.8 0.0 6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Anp1 PF03452.14 EDK38132.2 - 3.2e-119 397.2 0.0 4e-119 396.9 0.0 1.1 1 0 0 1 1 1 1 Anp1 ANT PF03374.14 EDK38132.2 - 0.053 13.8 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain Zn_clus PF00172.18 EDK38133.2 - 3e-05 24.0 10.1 8.6e-05 22.6 10.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.23 EDK38134.2 - 1.3e-17 64.3 2.2 2.1e-17 63.5 2.2 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK38134.2 - 4.1e-06 27.2 3.1 0.00079 19.7 0.7 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp PF00026.23 EDK38135.2 - 2.6e-14 53.4 0.0 2.6e-14 53.4 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic aspartyl protease Yip1 PF04893.17 EDK38136.2 - 0.0065 16.2 0.2 0.0099 15.6 0.2 1.2 1 0 0 1 1 1 1 Yip1 domain Hexapep PF00132.24 EDK38137.1 - 1.9e-12 46.4 2.7 1.2e-09 37.6 2.6 2.8 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDK38137.1 - 1.5e-08 34.2 4.4 5.4e-07 29.3 1.4 2.8 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 EDK38138.2 - 6.5e-11 41.5 6.8 5.8e-09 35.3 4.0 2.9 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDK38138.2 - 9.3e-07 28.5 8.1 9.4e-06 25.3 2.3 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EDK38138.2 - 0.00013 22.1 0.0 0.00037 20.7 0.0 1.8 1 0 0 1 1 1 1 Maltose acetyltransferase Kelch_6 PF13964.6 EDK38140.2 - 1.3e-07 31.7 4.1 5.2e-05 23.4 0.0 4.6 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 EDK38140.2 - 1e-06 28.2 0.0 0.0001 21.8 0.0 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 EDK38140.2 - 3.1e-06 27.3 6.1 6.3e-06 26.3 1.2 4.1 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 EDK38140.2 - 2.7e-05 24.1 2.5 0.027 14.5 0.1 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EDK38140.2 - 7e-05 22.6 0.8 0.036 14.0 0.1 3.3 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EDK38140.2 - 0.00057 19.8 0.0 0.22 11.6 0.0 3.2 2 0 0 2 2 2 1 Kelch motif PI3K_p85B PF02192.16 EDK38140.2 - 0.028 14.2 0.2 8.6 6.2 0.1 2.5 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain DUF4718 PF15842.5 EDK38140.2 - 2.6 7.8 11.9 8.7 6.1 3.0 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4718) GPS2_interact PF15784.5 EDK38140.2 - 2.7 8.5 19.0 0.04 14.4 4.8 4.3 4 0 0 4 4 4 0 G-protein pathway suppressor 2-interacting domain ADH_N PF08240.12 EDK38142.1 - 7.4e-29 99.8 0.6 1.4e-28 98.9 0.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK38142.1 - 7.9e-05 22.6 0.6 0.00015 21.7 0.6 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase RRM_1 PF00076.22 EDK38143.1 - 3.5e-21 74.8 0.1 8e-14 51.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK38143.1 - 0.051 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribonuc_P_40 PF08584.11 EDK38143.1 - 0.95 8.7 4.9 1.6 7.9 4.9 1.4 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit RabGAP-TBC PF00566.18 EDK38144.2 - 0.00098 18.8 7.4 0.1 12.3 0.1 3.1 3 0 0 3 3 3 2 Rab-GTPase-TBC domain Njmu-R1 PF15053.6 EDK38144.2 - 0.087 11.9 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Mjmu-R1-like protein family ENTH PF01417.20 EDK38145.2 - 4.9e-31 107.4 0.4 7.9e-31 106.7 0.4 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDK38145.2 - 0.027 13.5 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 ANTH domain ubiquitin PF00240.23 EDK38146.1 - 6.1e-201 650.6 34.7 6.3e-33 112.4 0.6 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.8 EDK38146.1 - 3.4e-94 308.7 35.5 3.8e-15 55.5 0.7 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDK38146.1 - 1.1e-32 112.4 18.9 0.0008 19.8 0.1 8.1 6 6 0 6 6 6 6 Ubiquitin-like domain TBK1_ULD PF18396.1 EDK38146.1 - 2.4e-23 81.9 8.3 0.049 13.6 0.0 6.2 6 0 0 6 6 6 6 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDK38146.1 - 2.7e-21 75.7 15.8 0.055 13.8 0.1 6.1 6 0 0 6 6 6 6 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDK38146.1 - 2.9e-20 72.4 6.7 0.23 11.6 0.0 7.0 6 5 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDK38146.1 - 2e-18 66.9 5.0 0.6 10.7 0.0 6.2 1 1 1 6 6 6 6 DUF2407 ubiquitin-like domain Methyltrans_RNA PF04452.14 EDK38146.1 - 7e-10 38.6 2.9 3.4 6.9 0.0 5.2 5 0 0 5 5 5 5 RNA methyltransferase DUF2870 PF11069.8 EDK38146.1 - 9.9e-09 35.5 0.0 50 4.4 0.0 6.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2870) Ubiquitin_4 PF18036.1 EDK38146.1 - 3.9e-08 33.2 40.0 28 4.8 0.2 11.8 12 0 0 12 12 12 0 Ubiquitin-like domain DUF3861 PF12977.7 EDK38146.1 - 8.9e-08 32.2 8.0 23 5.2 0.0 6.2 6 0 0 6 6 6 0 Domain of Unknown Function with PDB structure (DUF3861) Big_7 PF17957.1 EDK38146.1 - 2.1e-07 31.6 1.3 90 3.9 0.0 6.1 6 0 0 6 6 6 0 Bacterial Ig domain ACT_5 PF13710.6 EDK38146.1 - 2.7e-07 30.3 10.7 17 5.4 0.0 6.3 6 0 0 6 6 6 0 ACT domain UDP-g_GGTase PF06427.11 EDK38146.1 - 1.7e-06 28.1 10.6 13 6.0 0.0 5.8 6 0 0 6 6 6 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EDK38146.1 - 2.3e-06 27.2 0.0 41 3.5 0.0 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF969) DUF493 PF04359.14 EDK38146.1 - 5.6e-05 23.6 0.2 2.3e+02 2.4 0.0 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 EDK38146.1 - 8.3e-05 22.6 0.0 1.5e+02 2.6 0.0 6.0 6 0 0 6 6 6 0 ORF11CD3 domain YcgR_2 PF12945.7 EDK38146.1 - 0.00022 21.3 13.2 48 4.2 0.1 6.2 6 0 0 6 6 6 0 Flagellar protein YcgR ACT_4 PF13291.6 EDK38146.1 - 0.001 19.6 4.4 2.3e+02 2.4 0.0 6.0 6 0 0 6 6 6 0 ACT domain Baculo_p48 PF04878.13 EDK38146.1 - 0.0058 15.6 0.0 1.1e+02 1.5 0.0 4.6 5 0 0 5 5 5 0 Baculovirus P48 protein ProRS-C_2 PF09181.10 EDK38146.1 - 0.23 11.6 12.6 1.7e+02 2.4 0.1 5.9 6 0 0 6 6 6 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 EDK38146.1 - 0.32 11.2 44.7 9.8 6.5 1.4 6.3 6 0 0 6 6 6 0 Tash protein PEST motif HAMP_N3 PF18575.1 EDK38146.1 - 0.34 10.5 5.4 3.2e+02 1.0 0.0 5.4 6 0 0 6 6 6 0 HAMP N-terminal domain 3 SpoU_sub_bind PF08032.12 EDK38147.2 - 0.14 12.5 0.1 2.1 8.7 0.0 2.9 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Ecm29 PF13001.7 EDK38148.2 - 1e-127 426.9 3.1 1.7e-127 426.1 1.7 2.0 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.22 EDK38148.2 - 1.7e-06 27.8 0.9 0.91 10.0 0.1 5.7 5 0 0 5 5 5 2 HEAT repeat Cyclin_N PF00134.23 EDK38148.2 - 0.052 13.3 0.1 3 7.6 0.0 2.5 2 0 0 2 2 2 0 Cyclin, N-terminal domain YueH PF14166.6 EDK38148.2 - 0.085 12.7 0.8 1.2 9.0 0.6 2.9 3 0 0 3 3 3 0 YueH-like protein IF-2B PF01008.17 EDK38149.2 - 2e-77 260.2 0.2 7.5e-77 258.3 0.2 1.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family BORG_CEP PF14957.6 EDK38149.2 - 9.7 7.4 9.6 37 5.5 3.3 2.4 2 0 0 2 2 2 0 Cdc42 effector PhoLip_ATPase_C PF16212.5 EDK38150.2 - 1.6e-82 277.0 22.3 1.6e-82 277.0 22.3 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDK38150.2 - 5.4e-24 83.7 13.4 7e-24 83.3 11.4 2.3 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EDK38150.2 - 2.6e-11 44.2 1.5 1e-05 25.9 0.5 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDK38150.2 - 1.4e-10 41.1 0.0 5.5e-10 39.2 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EDK38150.2 - 0.00015 21.4 0.0 0.00034 20.2 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDK38150.2 - 0.0024 17.7 0.1 0.02 14.7 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF5613 PF18467.1 EDK38150.2 - 4.5 7.8 6.8 4.7 7.7 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5613) Aldedh PF00171.22 EDK38151.2 - 8.9e-20 70.6 0.6 5e-15 55.0 0.5 2.7 2 1 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 EDK38151.2 - 0.02 14.0 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) GDI PF00996.18 EDK38152.2 - 7.7e-38 130.1 0.2 4.2e-37 127.7 0.0 2.0 2 0 0 2 2 2 1 GDP dissociation inhibitor FAD_binding_3 PF01494.19 EDK38152.2 - 0.0082 15.4 0.0 0.033 13.4 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDK38152.2 - 0.16 12.2 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Ribosomal_L7Ae PF01248.26 EDK38153.1 - 3.7e-25 87.5 0.6 4.9e-25 87.1 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Gin PF10764.9 EDK38153.1 - 0.014 15.3 0.8 0.024 14.6 0.8 1.3 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin SBD_N PF07005.11 EDK38153.1 - 0.042 13.6 0.1 0.053 13.3 0.1 1.2 1 0 0 1 1 1 0 Sugar-binding N-terminal domain NTP_transf_3 PF12804.7 EDK38153.1 - 0.076 13.4 0.0 0.098 13.0 0.0 1.4 1 1 0 1 1 1 0 MobA-like NTP transferase domain KNOX2 PF03791.13 EDK38153.1 - 0.086 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 KNOX2 domain CorA PF01544.18 EDK38154.2 - 0.00048 19.5 1.5 0.00053 19.4 1.5 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein APG6_N PF17675.1 EDK38154.2 - 0.00092 19.7 1.9 0.0013 19.2 1.9 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region EzrA PF06160.12 EDK38154.2 - 0.002 16.4 3.9 0.0023 16.2 3.9 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4201 PF13870.6 EDK38154.2 - 0.0061 16.3 4.2 0.0061 16.3 4.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) DivIC PF04977.15 EDK38154.2 - 0.0084 15.9 1.0 0.0084 15.9 1.0 2.3 2 1 1 3 3 2 1 Septum formation initiator HD_3 PF13023.6 EDK38154.2 - 0.016 15.2 0.8 0.016 15.2 0.8 1.5 1 1 1 2 2 2 0 HD domain Scaffolding_pro PF11418.8 EDK38154.2 - 0.017 15.7 3.2 1 9.9 0.3 2.6 2 1 1 3 3 3 0 Phi29 scaffolding protein GAS PF13851.6 EDK38154.2 - 0.017 14.4 6.2 0.021 14.2 6.2 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EDK38154.2 - 0.021 14.9 3.2 0.23 11.5 0.6 2.3 1 1 1 2 2 2 0 Laminin Domain II CENP-H PF05837.12 EDK38154.2 - 0.021 15.2 2.1 0.031 14.7 2.1 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DHR10 PF18595.1 EDK38154.2 - 0.024 14.7 3.9 2.1 8.5 2.5 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain YabA PF06156.13 EDK38154.2 - 0.03 15.0 3.3 0.035 14.8 2.2 1.8 1 1 1 2 2 2 0 Initiation control protein YabA Spc7 PF08317.11 EDK38154.2 - 0.034 13.0 4.4 0.048 12.5 4.3 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4527 PF15030.6 EDK38154.2 - 0.042 13.3 0.3 0.055 12.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) NPV_P10 PF05531.12 EDK38154.2 - 0.053 14.0 1.8 5.2 7.6 0.1 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EDK38154.2 - 0.075 13.1 3.0 0.18 11.8 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF5344 PF17279.2 EDK38154.2 - 0.075 13.6 1.7 0.93 10.1 0.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Cortex-I_coil PF09304.10 EDK38154.2 - 0.1 12.8 4.3 0.1 12.8 0.5 2.4 1 1 1 2 2 2 0 Cortexillin I, coiled coil Occludin_ELL PF07303.13 EDK38154.2 - 0.37 11.5 5.6 0.36 11.6 4.4 1.6 2 0 0 2 2 1 0 Occludin homology domain Cornichon PF03311.14 EDK38155.1 - 8e-49 165.0 7.0 9.1e-49 164.8 7.0 1.0 1 0 0 1 1 1 1 Cornichon protein HRI1 PF16815.5 EDK38156.2 - 7.7e-50 169.7 0.0 8.7e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Protein HRI1 LRR_4 PF12799.7 EDK38157.2 - 6.1e-16 58.3 29.5 2.9e-06 27.5 5.0 4.9 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK38157.2 - 1.2e-11 44.2 29.8 1.4e-05 24.7 0.6 4.6 2 1 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 EDK38157.2 - 7.3e-07 28.8 11.8 0.0033 16.9 3.5 3.4 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EDK38157.2 - 0.037 14.1 24.1 4.3 7.6 1.1 6.3 6 0 0 6 6 6 0 Leucine Rich repeat Nas2_N PF18265.1 EDK38158.2 - 0.035 14.0 0.2 0.21 11.5 0.1 2.4 2 0 0 2 2 2 0 Nas2 N_terminal domain GIT_CC PF16559.5 EDK38158.2 - 1.1 9.2 6.3 6.6 6.7 1.4 3.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor RRM_1 PF00076.22 EDK38159.2 - 2.7e-47 158.4 0.1 1.1e-18 66.9 0.1 4.2 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK38159.2 - 1.2e-05 25.2 0.0 0.00061 19.7 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EDK38159.2 - 2.4e-05 23.9 0.0 0.00047 19.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK38159.2 - 0.00011 22.3 0.0 0.0042 17.2 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 EDK38159.2 - 0.00028 20.7 0.0 0.057 13.3 0.0 3.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EDK38159.2 - 0.0069 16.4 0.0 0.0069 16.4 0.0 2.5 4 0 0 4 4 4 1 RNA binding motif Nup35_RRM PF05172.13 EDK38159.2 - 0.1 12.6 0.0 8.2 6.5 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Histone PF00125.24 EDK38160.1 - 2.7e-51 173.3 2.4 3e-51 173.2 2.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDK38160.1 - 3.5e-06 27.3 0.0 5.3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDK38160.1 - 2.2e-05 24.5 0.1 4.3e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDK38160.1 - 0.00013 22.5 1.2 0.00016 22.3 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDK38160.1 - 0.0012 19.0 0.8 0.0017 18.6 0.1 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDK38160.1 - 0.022 14.8 0.3 0.035 14.2 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Oxidored_q6 PF01058.22 EDK38161.1 - 2e-21 76.2 0.1 2.9e-21 75.7 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit EnY2 PF10163.9 EDK38162.2 - 4.9e-30 103.7 0.6 5.7e-30 103.5 0.6 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 AROS PF15684.5 EDK38162.2 - 0.043 14.4 0.2 0.051 14.1 0.2 1.1 1 0 0 1 1 1 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 NUDIX PF00293.28 EDK38163.2 - 7.2e-14 52.0 0.0 1.1e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain FANCL_C PF11793.8 EDK38164.2 - 0.0013 18.9 1.9 0.084 13.1 0.3 2.6 2 0 0 2 2 2 1 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EDK38164.2 - 0.067 12.8 1.5 0.076 12.6 0.1 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type NPCC PF08058.11 EDK38164.2 - 0.15 12.1 0.1 0.38 10.8 0.1 1.7 1 0 0 1 1 1 0 Nuclear pore complex component RINGv PF12906.7 EDK38164.2 - 0.16 12.1 2.6 0.14 12.3 0.6 2.0 2 0 0 2 2 2 0 RING-variant domain Subtilosin_A PF11420.8 EDK38164.2 - 0.41 10.7 2.5 1.6 8.7 0.2 2.5 2 0 0 2 2 2 0 Bacteriocin subtilosin A TPR_1 PF00515.28 EDK38165.2 - 2.1e-54 179.2 28.8 1.2e-07 31.3 0.0 11.5 11 2 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38165.2 - 1.8e-52 171.3 25.6 3.4e-06 26.7 0.0 10.5 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EDK38165.2 - 1.2e-36 121.8 16.2 0.00049 20.1 0.0 11.1 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_17 PF13431.6 EDK38165.2 - 7.1e-34 113.7 16.7 0.00045 20.4 0.1 10.3 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 EDK38165.2 - 7.1e-32 108.8 28.8 2.4e-06 27.1 0.0 9.8 4 3 7 11 11 11 8 TPR repeat TPR_19 PF14559.6 EDK38165.2 - 7.9e-32 109.6 14.9 2.1e-05 24.9 0.3 6.9 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_16 PF13432.6 EDK38165.2 - 2.5e-31 108.1 13.5 1.1e-05 26.0 0.0 6.4 5 1 0 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 EDK38165.2 - 1.1e-29 100.5 15.8 1.2e-05 25.7 0.1 9.6 3 2 7 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38165.2 - 6.2e-25 87.3 24.2 0.00013 22.2 0.6 8.1 4 2 4 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 EDK38165.2 - 1.7e-24 84.0 15.8 0.0016 18.4 0.1 9.4 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 EDK38165.2 - 1.7e-23 82.5 15.2 7.1e-05 22.9 0.1 6.7 3 2 2 7 7 7 7 Tetratricopeptide repeat TPR_6 PF13174.6 EDK38165.2 - 3.8e-22 77.4 15.7 0.0044 17.6 0.0 9.5 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK38165.2 - 1.9e-13 50.4 10.4 4.6e-07 30.0 0.5 3.8 4 1 1 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EDK38165.2 - 8e-13 48.2 5.4 0.0011 18.2 0.1 5.9 2 2 2 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK38165.2 - 2.9e-11 43.3 0.3 0.0017 17.8 0.1 4.3 3 1 2 5 5 5 3 MalT-like TPR region NARP1 PF12569.8 EDK38165.2 - 1.1e-06 27.9 0.1 0.6 8.9 0.0 4.4 3 1 1 5 5 5 2 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 EDK38165.2 - 1.1e-06 28.3 20.7 0.31 11.0 0.3 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_21 PF09976.9 EDK38165.2 - 2.1e-06 27.6 0.9 0.35 10.5 0.0 4.1 4 1 0 4 4 4 2 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 EDK38165.2 - 0.00067 19.7 4.3 0.097 12.8 0.0 5.1 6 0 0 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 EDK38165.2 - 0.0024 16.9 0.1 0.13 11.2 0.0 2.8 2 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 EDK38165.2 - 0.0025 17.3 7.1 5.9 6.2 0.2 4.8 1 1 3 4 4 4 1 Soluble NSF attachment protein, SNAP TPR_20 PF14561.6 EDK38165.2 - 0.034 14.5 0.1 9.8 6.6 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Cohesin_load PF10345.9 EDK38165.2 - 0.035 12.6 0.2 0.69 8.3 0.0 2.6 2 1 0 3 3 3 0 Cohesin loading factor TOM20_plant PF06552.12 EDK38165.2 - 0.078 12.7 2.0 11 5.7 0.1 3.7 3 2 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 Paf67 PF10255.9 EDK38165.2 - 0.11 11.5 0.2 0.5 9.3 0.1 2.0 2 0 0 2 2 2 0 RNA polymerase I-associated factor PAF67 TPR_4 PF07721.14 EDK38165.2 - 0.47 11.2 2.2 18 6.3 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDK38165.2 - 2.2 8.4 20.6 16 5.6 0.3 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat BTAD PF03704.17 EDK38165.2 - 3.3 8.1 8.4 7 7.1 0.2 3.5 2 2 2 4 4 4 0 Bacterial transcriptional activator domain NAD_kinase PF01513.21 EDK38166.2 - 9.7e-53 179.2 0.0 1.2e-52 178.9 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EDK38166.2 - 0.0026 17.4 0.0 0.0047 16.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Glyco_tran_28_C PF04101.16 EDK38166.2 - 0.021 14.8 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Hist_deacetyl PF00850.19 EDK38167.2 - 5.1e-81 272.5 0.0 6.7e-81 272.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain RunxI PF08504.11 EDK38167.2 - 0.0064 17.2 1.1 0.0064 17.2 1.1 2.2 2 0 0 2 2 2 1 Runx inhibition domain DHHC PF01529.20 EDK38168.2 - 2.8e-36 124.6 12.0 2.8e-36 124.6 12.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase LapA_dom PF06305.11 EDK38168.2 - 1.2 9.0 0.0 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain UAA PF08449.11 EDK38169.2 - 1.3e-40 139.5 16.8 1.6e-40 139.2 16.8 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 EDK38169.2 - 5.5e-05 22.7 15.7 0.0018 17.7 3.7 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EDK38169.2 - 0.00066 19.9 28.1 0.057 13.6 10.0 3.4 3 1 1 4 4 4 2 EamA-like transporter family SRP68 PF16969.5 EDK38170.2 - 2.7e-58 198.4 10.6 3.8e-57 194.6 10.6 2.2 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 PALP PF00291.25 EDK38172.2 - 2.8e-76 256.7 0.0 4.6e-76 256.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EDK38172.2 - 3.2e-44 148.6 0.1 9.3e-27 92.6 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase GTP_EFTU PF00009.27 EDK38173.2 - 1.8e-49 167.9 0.0 3.3e-49 167.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EDK38173.2 - 2.5e-40 136.9 8.2 3.6e-39 133.2 6.7 2.3 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EDK38173.2 - 2.2e-21 75.7 0.0 4.6e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDK38173.2 - 1e-06 29.0 0.5 2.4e-06 27.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK38173.2 - 6.8e-05 22.9 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EDK38173.2 - 0.00018 21.1 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Ras family RF3_C PF16658.5 EDK38173.2 - 0.005 16.7 0.1 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain EFG_II PF14492.6 EDK38173.2 - 0.0099 16.0 0.0 0.029 14.4 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.10 EDK38173.2 - 0.013 14.9 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Aminotran_5 PF00266.19 EDK38174.1 - 3.2e-29 102.0 0.0 3.6e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Hus1 PF04005.12 EDK38175.2 - 2.1e-48 165.0 0.4 2.5e-48 164.7 0.4 1.0 1 0 0 1 1 1 1 Hus1-like protein LSM PF01423.22 EDK38176.1 - 2.2e-16 59.3 0.8 2.9e-16 58.9 0.8 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDK38176.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Hfq protein CPSF73-100_C PF11718.8 EDK38177.2 - 7.3e-64 215.3 0.0 1.1e-63 214.7 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EDK38177.2 - 4.2e-30 104.3 0.0 8.6e-30 103.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EDK38177.2 - 2e-22 80.2 0.9 4.1e-22 79.2 0.9 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EDK38177.2 - 4.5e-18 65.4 0.0 9.5e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EDK38177.2 - 1.8e-16 59.8 0.0 4.7e-16 58.5 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EDK38177.2 - 5.1e-06 26.5 0.0 1.6e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EDK38177.2 - 7.2e-06 25.7 1.1 8.9e-05 22.1 0.3 2.7 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EDK38177.2 - 0.012 14.8 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family MCM PF00493.23 EDK38178.1 - 7.6e-105 349.0 0.0 1.4e-104 348.1 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDK38178.1 - 4.4e-37 126.7 1.2 7.8e-37 125.9 1.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDK38178.1 - 1.3e-27 96.0 1.8 3.6e-27 94.6 1.8 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDK38178.1 - 6.3e-16 58.9 0.3 1.6e-15 57.5 0.3 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDK38178.1 - 1.8e-06 27.5 0.0 0.00068 19.1 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDK38178.1 - 1.5e-05 25.0 0.0 4.2e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDK38178.1 - 0.00016 21.6 0.1 0.0021 17.9 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDK38178.1 - 0.035 13.8 0.0 0.97 9.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_lid_7 PF17867.1 EDK38178.1 - 0.079 13.2 0.3 0.28 11.4 0.3 1.9 1 0 0 1 1 1 0 Midasin AAA lid domain AAA PF00004.29 EDK38178.1 - 0.14 12.6 0.0 0.69 10.3 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RF-1 PF00472.20 EDK38179.2 - 2.7e-22 78.9 4.7 3.6e-22 78.5 4.4 1.3 1 1 0 1 1 1 1 RF-1 domain MIR PF02815.19 EDK38179.2 - 0.015 15.2 0.1 0.046 13.6 0.0 1.8 1 1 1 2 2 2 0 MIR domain ADIP PF11559.8 EDK38180.2 - 7.3e-50 169.0 16.3 7.3e-50 169.0 16.3 1.8 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding TRAF_BIRC3_bd PF16673.5 EDK38180.2 - 1.5e-05 24.7 3.9 2.1e-05 24.2 1.3 2.6 2 0 0 2 2 2 1 TNF receptor-associated factor BIRC3 binding domain TMF_DNA_bd PF12329.8 EDK38180.2 - 0.0059 16.6 5.4 0.0059 16.6 5.4 3.1 4 0 0 4 4 4 1 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 EDK38180.2 - 0.026 14.4 0.3 14 5.7 0.0 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.15 EDK38180.2 - 0.027 14.0 11.1 0.43 10.1 7.4 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit FAM184 PF15665.5 EDK38180.2 - 0.033 14.0 6.4 4 7.2 3.9 2.5 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B PPDK_N PF01326.19 EDK38180.2 - 0.072 12.3 3.1 0.043 13.1 1.0 1.6 2 0 0 2 2 2 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF4407 PF14362.6 EDK38180.2 - 0.09 12.1 5.8 0.17 11.2 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glutaredoxin2_C PF04399.13 EDK38180.2 - 0.096 12.5 4.1 0.078 12.8 2.0 1.9 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF5082 PF16888.5 EDK38180.2 - 0.22 11.8 20.1 0.12 12.7 7.4 3.5 3 2 0 3 3 3 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EDK38180.2 - 0.28 11.2 11.1 1.5 8.9 6.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 EDK38180.2 - 0.31 10.3 12.0 0.29 10.5 10.2 1.8 1 1 0 1 1 1 0 FAM76 protein DUF4094 PF13334.6 EDK38180.2 - 0.49 10.9 10.7 66 4.0 0.0 4.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) DUF641 PF04859.12 EDK38180.2 - 1 9.7 8.9 13 6.1 2.4 2.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) APG6_N PF17675.1 EDK38180.2 - 1.2 9.7 10.7 3.1 8.3 4.1 3.0 2 1 0 2 2 2 0 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 EDK38180.2 - 1.4 9.1 17.6 0.27 11.4 5.6 3.2 2 1 1 3 3 3 0 Tropomyosin like Filament PF00038.21 EDK38180.2 - 1.5 8.3 15.2 0.26 10.8 7.9 2.6 2 1 0 2 2 2 0 Intermediate filament protein SlyX PF04102.12 EDK38180.2 - 2.1 9.0 12.1 1.1 9.9 6.1 3.3 2 1 1 3 3 3 0 SlyX ABC_tran_CTD PF16326.5 EDK38180.2 - 2.3 8.6 7.1 1.3 9.3 1.5 3.1 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF4795 PF16043.5 EDK38180.2 - 2.3 7.8 16.5 24 4.4 12.8 2.9 2 2 0 3 3 3 0 Domain of unknown function (DUF4795) DUF16 PF01519.16 EDK38180.2 - 3.7 8.1 14.4 3.6 8.1 10.5 2.9 3 1 0 3 3 3 0 Protein of unknown function DUF16 CENP-F_leu_zip PF10473.9 EDK38180.2 - 5 7.1 14.0 6.5 6.8 6.6 3.2 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.9 EDK38180.2 - 7.6 6.9 19.5 1.2 9.5 3.2 4.3 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 EDK38180.2 - 8 6.5 17.7 1.3 9.1 12.3 2.3 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Ras PF00071.22 EDK38181.1 - 2.7e-49 166.9 0.0 3.3e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK38181.1 - 3.6e-29 101.4 0.0 9.4e-29 100.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK38181.1 - 2e-10 40.4 0.0 2.5e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 EDK38181.1 - 0.00051 20.4 0.1 0.0022 18.4 0.1 1.9 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 EDK38181.1 - 0.0012 18.9 0.0 0.0022 18.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDK38181.1 - 0.0024 17.3 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EDK38181.1 - 0.018 14.8 0.1 0.024 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EDK38181.1 - 0.021 14.7 0.1 6 6.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Pox_A32 PF04665.12 EDK38181.1 - 0.021 14.3 0.1 0.039 13.4 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 EDK38181.1 - 0.03 13.5 2.1 1.6 7.8 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit AAA_7 PF12775.7 EDK38181.1 - 0.038 13.5 0.1 0.066 12.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EDK38181.1 - 0.086 12.8 0.1 0.19 11.7 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EDK38181.1 - 0.12 12.6 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EDK38181.1 - 0.15 11.3 0.3 0.25 10.6 0.0 1.6 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 EDK38181.1 - 0.16 12.3 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain RRM_1 PF00076.22 EDK38182.2 - 1.1e-11 44.4 3.5 0.0018 18.0 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aa_trans PF01490.18 EDK38183.2 - 2.5e-53 181.3 32.1 3e-53 181.0 32.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDK38183.2 - 0.00018 20.7 10.4 0.00018 20.7 10.4 2.2 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family KilA-N PF04383.13 EDK38184.2 - 4.9e-05 23.1 0.0 0.0034 17.2 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain Glyoxalase PF00903.25 EDK38185.2 - 3.4e-08 33.7 0.0 5.4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDK38185.2 - 0.00015 22.0 0.0 0.00037 20.7 0.0 1.7 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MHC_II_alpha PF00993.20 EDK38186.2 - 0.1 12.3 0.8 0.3 10.8 0.2 2.1 2 0 0 2 2 2 0 Class II histocompatibility antigen, alpha domain Plavaka PF18759.1 EDK38186.2 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Plavaka transposase RTA1 PF04479.13 EDK38187.2 - 2.2e-69 233.2 5.8 2.8e-69 232.9 5.8 1.0 1 0 0 1 1 1 1 RTA1 like protein Cytochrome-c551 PF10643.9 EDK38187.2 - 0.055 13.0 0.6 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 DUF202 PF02656.15 EDK38187.2 - 0.41 11.1 5.5 0.39 11.2 1.6 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF202) RTA1 PF04479.13 EDK38188.1 - 1e-22 80.8 1.6 1.3e-22 80.5 1.6 1.1 1 0 0 1 1 1 1 RTA1 like protein VanZ PF04892.12 EDK38188.1 - 0.0048 17.5 1.5 0.019 15.6 1.5 1.8 1 1 1 2 2 2 1 VanZ like family RTA1 PF04479.13 EDK38189.2 - 5.1e-40 137.3 10.0 6.5e-40 137.0 10.0 1.1 1 0 0 1 1 1 1 RTA1 like protein RTA1 PF04479.13 EDK38190.1 - 3.7e-57 193.3 7.7 4.4e-57 193.0 7.7 1.0 1 0 0 1 1 1 1 RTA1 like protein RTA1 PF04479.13 EDK38191.2 - 0.0035 17.0 0.0 0.0035 17.0 0.0 2.5 2 1 1 3 3 3 1 RTA1 like protein zf-Di19 PF05605.12 EDK38191.2 - 0.033 14.5 0.1 0.061 13.6 0.1 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PhnA_Zn_Ribbon PF08274.12 EDK38191.2 - 0.067 13.2 0.7 0.16 12.0 0.7 1.7 1 1 0 1 1 1 0 PhnA Zinc-Ribbon UPF0547 PF10571.9 EDK38191.2 - 0.11 12.6 0.3 0.11 12.6 0.3 1.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Aldo_ket_red PF00248.21 EDK38192.1 - 5.5e-48 163.7 0.0 7.3e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2380 PF09533.10 EDK38192.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Ribosomal_L28e PF01778.17 EDK38193.2 - 6.6e-39 133.2 3.3 6.6e-39 133.2 3.3 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EDK38193.2 - 9e-31 106.5 14.9 9e-31 106.5 14.9 2.4 1 1 1 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EDK38193.2 - 0.0011 18.4 14.7 0.0014 18.0 14.7 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 EDK38193.2 - 0.065 13.0 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 Conserved carboxylase domain Motile_Sperm PF00635.26 EDK38193.2 - 0.13 12.1 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 MSP (Major sperm protein) domain TFIIF_alpha PF05793.12 EDK38193.2 - 0.87 8.1 22.0 1 7.9 22.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Glyco_hydro_3_C PF01915.22 EDK38194.2 - 1.6e-33 116.4 0.1 3.1e-33 115.4 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EDK38194.2 - 8.2e-23 80.3 0.0 1.5e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 EDK38194.2 - 0.0041 17.4 0.1 0.0078 16.5 0.1 1.5 1 0 0 1 1 1 1 CARDB Phage_tail_X PF05489.12 EDK38194.2 - 0.21 11.3 0.4 0.63 9.7 0.0 1.9 2 0 0 2 2 2 0 Phage Tail Protein X Glyco_hydro_3 PF00933.21 EDK38195.1 - 3.7e-45 154.7 0.0 5.8e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PA14 PF07691.12 EDK38195.1 - 1.5e-16 60.5 0.2 2.7e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 PA14 domain Glyco_hydro_3_C PF01915.22 EDK38195.1 - 1.1e-15 58.2 0.0 1.6e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fungal_trans PF04082.18 EDK38196.2 - 7.2e-10 38.3 0.3 2e-09 36.9 0.3 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK38196.2 - 5.9e-07 29.5 8.3 1.3e-06 28.4 8.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_12 PF18095.1 EDK38196.2 - 0.00053 19.6 0.1 0.0012 18.5 0.1 1.6 1 0 0 1 1 1 1 UPF0242 C-terminal PAS-like domain ABC_tran_CTD PF16326.5 EDK38196.2 - 0.0075 16.5 0.7 0.018 15.3 0.7 1.7 1 0 0 1 1 1 1 ABC transporter C-terminal domain Sugar_tr PF00083.24 EDK38197.2 - 3.8e-12 45.8 0.1 4.2e-12 45.7 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Lipase3_N PF03893.16 EDK38198.2 - 0.072 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Lipase 3 N-terminal region DUF3987 PF13148.6 EDK38199.2 - 0.015 14.3 1.3 0.028 13.4 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF4230 PF14014.6 EDK38199.2 - 1.1 9.5 7.0 0.61 10.4 1.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4230) Ground-like PF04155.18 EDK38199.2 - 2.7 8.7 8.8 20 5.9 1.0 4.0 4 1 0 4 4 4 0 Ground-like domain DUF1764 PF08576.10 EDK38199.2 - 7.6 7.5 7.9 16 6.5 0.8 2.8 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) MFS_2 PF13347.6 EDK38200.2 - 1.7e-06 26.9 6.2 1.7e-06 26.9 6.2 2.9 2 1 0 2 2 2 1 MFS/sugar transport protein TRI12 PF06609.13 EDK38200.2 - 5.4e-05 21.8 20.9 7.5e-05 21.3 20.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK38200.2 - 5.8e-05 22.1 13.7 5.8e-05 22.1 13.7 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK38200.2 - 0.03 13.3 45.2 0.37 9.7 45.2 2.6 1 1 0 1 1 1 0 Major Facilitator Superfamily Pox_A14 PF05767.12 EDK38200.2 - 0.11 12.7 0.3 0.11 12.7 0.3 3.8 3 1 2 5 5 5 0 Poxvirus virion envelope protein A14 Candida_ALS PF05792.13 EDK38202.2 - 1.6e-81 268.5 322.1 1.5e-09 38.3 16.8 16.2 17 0 0 17 17 17 12 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.8 EDK38204.2 - 1.9e-78 263.2 5.5 1.9e-78 263.2 5.5 1.9 2 0 0 2 2 2 1 Cell-wall agglutinin N-terminal ligand-sugar binding Candida_ALS PF05792.13 EDK38204.2 - 8.5e-57 189.4 277.0 3e-09 37.3 24.6 11.9 12 1 0 12 12 12 9 Candida agglutinin-like (ALS) ABC_membrane PF00664.23 EDK38205.2 - 4.3e-61 207.0 48.6 1e-35 123.7 24.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK38205.2 - 6.3e-48 162.8 0.8 1.7e-29 103.1 0.1 3.4 2 1 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 EDK38205.2 - 1.1e-05 25.4 1.1 0.073 13.0 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EDK38205.2 - 1.3e-05 24.9 3.6 0.0041 16.8 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK38205.2 - 1.9e-05 25.1 0.3 0.0087 16.5 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDK38205.2 - 3.5e-05 23.9 1.3 0.021 14.9 0.1 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EDK38205.2 - 5e-05 23.9 8.0 0.012 16.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain T2SSE PF00437.20 EDK38205.2 - 0.00017 20.7 0.0 0.064 12.3 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein cobW PF02492.19 EDK38205.2 - 0.0002 21.0 0.6 0.063 12.9 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EDK38205.2 - 0.00028 20.4 10.8 2.4 7.5 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK38205.2 - 0.00047 20.0 2.0 6.3 6.5 0.0 3.8 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EDK38205.2 - 0.00053 20.5 0.1 0.88 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EDK38205.2 - 0.0011 19.1 4.4 0.74 9.9 0.1 3.1 3 0 0 3 3 3 2 Dynamin family AAA_22 PF13401.6 EDK38205.2 - 0.0023 18.2 4.4 1.2 9.4 1.6 3.4 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDK38205.2 - 0.0035 17.1 4.1 0.22 11.2 0.2 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 EDK38205.2 - 0.0061 16.1 0.3 1.9 8.0 0.0 2.8 3 0 0 3 3 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 EDK38205.2 - 0.0066 15.8 0.1 0.38 10.0 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 EDK38205.2 - 0.013 15.2 1.6 0.47 10.1 0.1 2.8 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EDK38205.2 - 0.024 14.4 1.6 0.25 11.1 0.2 2.7 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EDK38205.2 - 0.025 14.2 0.5 0.8 9.3 0.0 2.6 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.17 EDK38205.2 - 0.046 13.5 0.2 13 5.5 0.1 3.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA PF00004.29 EDK38205.2 - 0.047 14.1 0.9 0.85 10.0 0.1 3.4 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 EDK38205.2 - 0.058 12.7 0.2 3.1 7.1 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 EDK38205.2 - 0.066 13.3 0.5 0.23 11.5 0.2 2.0 1 1 0 1 1 1 0 Helicase HerA, central domain PRK PF00485.18 EDK38205.2 - 0.091 12.5 2.2 1.7 8.4 0.1 3.2 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family ATPase_2 PF01637.18 EDK38205.2 - 0.097 12.6 0.9 3.5 7.5 0.0 3.2 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EDK38205.2 - 0.21 11.5 0.9 0.64 9.9 0.1 2.2 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 EDK38205.2 - 0.31 11.1 2.1 22 5.1 0.1 3.4 2 1 1 3 3 3 0 AAA domain Pkinase PF00069.25 EDK38206.2 - 5.9e-60 202.9 0.2 3.8e-35 121.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38206.2 - 1.7e-37 129.1 0.0 1.7e-36 125.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK38206.2 - 6.5e-05 21.9 0.7 0.00058 18.8 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EDK38206.2 - 0.0057 16.6 0.0 0.61 10.0 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family FapA PF03961.13 EDK38206.2 - 0.62 8.6 4.9 1.2 7.7 4.9 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A SAICAR_synt PF01259.18 EDK38207.2 - 4.3e-104 347.6 0.1 5e-104 347.4 0.1 1.0 1 0 0 1 1 1 1 SAICAR synthetase MutS_V PF00488.21 EDK38208.2 - 8.9e-81 270.4 0.1 1.6e-80 269.6 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDK38208.2 - 9.9e-31 107.5 1.6 2.3e-30 106.3 1.6 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EDK38208.2 - 3e-14 53.1 2.0 1.1e-13 51.3 2.0 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EDK38208.2 - 6.5e-13 49.1 0.8 1.4e-12 48.0 0.0 2.0 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.20 EDK38208.2 - 0.00099 19.3 0.2 0.0095 16.2 0.1 2.4 2 0 0 2 2 2 1 MutS domain I DUF3187 PF11383.8 EDK38208.2 - 0.013 14.7 0.2 0.022 14.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3187) baeRF_family8 PF18851.1 EDK38208.2 - 0.018 15.1 0.2 0.94 9.5 0.0 3.2 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 8 baeRF_family11 PF18855.1 EDK38208.2 - 0.044 14.1 0.0 0.53 10.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 Ceramidase PF05875.12 EDK38209.2 - 6e-97 324.2 10.8 7.2e-97 323.9 10.8 1.0 1 0 0 1 1 1 1 Ceramidase MerC PF03203.14 EDK38209.2 - 0.042 14.3 12.1 1.7 9.1 3.2 2.8 1 1 1 2 2 2 0 MerC mercury resistance protein DUF4131 PF13567.6 EDK38209.2 - 1.4 8.5 7.9 4 7.1 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) p450 PF00067.22 EDK38210.2 - 5.3e-42 144.1 1.2 7.4e-39 133.8 0.0 2.3 1 1 0 2 2 2 2 Cytochrome P450 Cellulose_synt PF03552.14 EDK38210.2 - 0.02 13.4 0.0 0.028 12.9 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase PAPS_reduct PF01507.19 EDK38211.2 - 2.5e-42 144.9 0.0 3.5e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DNA_binding_1 PF01035.20 EDK38212.2 - 4.1e-25 87.7 0.1 7e-25 87.0 0.1 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain PH PF00169.29 EDK38214.2 - 7.1e-08 32.9 1.0 7.1e-08 32.9 1.0 3.2 4 0 0 4 4 4 1 PH domain Prefoldin_2 PF01920.20 EDK38214.2 - 0.0061 16.5 4.0 0.23 11.4 0.0 3.3 3 0 0 3 3 3 2 Prefoldin subunit GTP-bdg_M PF16360.5 EDK38214.2 - 1.1 9.9 3.9 1.8 9.2 0.3 2.5 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region DUF1178 PF06676.11 EDK38214.2 - 2.7 8.4 4.8 1.6 9.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) CDP-OH_P_transf PF01066.21 EDK38215.1 - 2.8e-12 47.2 0.5 6.7e-12 46.0 0.5 1.7 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase NIF PF03031.18 EDK38217.2 - 3.5e-44 150.3 0.0 6.8e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HTH_56 PF18662.1 EDK38217.2 - 0.032 14.3 1.6 1.6 8.8 0.3 3.3 3 0 0 3 3 3 0 Cch helix turn helix domain R-HINP1I PF11463.8 EDK38217.2 - 0.041 13.3 0.1 0.067 12.6 0.1 1.4 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease Hap4_Hap_bind PF10297.9 EDK38218.2 - 1.5e-08 34.5 7.3 1.5e-08 34.5 7.3 2.2 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EDK38218.2 - 2.8e-05 24.1 16.7 0.00052 20.1 10.7 2.7 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 EDK38218.2 - 0.017 15.2 19.9 0.29 11.2 11.8 2.7 1 1 1 2 2 2 0 Basic region leucine zipper dsrm PF00035.26 EDK38218.2 - 0.11 13.2 0.0 0.38 11.5 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif DUF4758 PF15950.5 EDK38218.2 - 0.22 11.9 2.4 0.26 11.6 0.1 2.3 3 0 0 3 3 3 0 Putative sperm flagellar membrane protein Pet127 PF08634.10 EDK38219.2 - 2.6e-108 361.6 0.1 3.9e-108 361.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 6PF2K PF01591.18 EDK38220.1 - 2e-48 164.6 1.3 3e-48 164.0 1.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 EDK38220.1 - 2.1e-09 37.7 0.0 3.7e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EDK38220.1 - 2.6e-07 30.7 0.0 4.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase KTI12 PF08433.10 EDK38220.1 - 6.3e-07 29.1 0.0 9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 EDK38220.1 - 2.3e-06 28.1 0.0 4.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK38220.1 - 1.5e-05 25.6 0.0 2.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDK38220.1 - 6.9e-05 22.6 0.1 0.00014 21.5 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EDK38220.1 - 0.0012 18.4 0.0 0.0018 17.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain G-alpha PF00503.20 EDK38220.1 - 0.0013 18.0 0.2 0.0021 17.3 0.2 1.3 1 1 0 1 1 1 1 G-protein alpha subunit AAA_15 PF13175.6 EDK38220.1 - 0.0019 18.0 0.4 0.0028 17.4 0.4 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EDK38220.1 - 0.0027 17.3 0.1 0.023 14.2 0.0 2.1 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 EDK38220.1 - 0.0028 18.1 0.0 0.0038 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EDK38220.1 - 0.0041 16.4 0.0 0.0073 15.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin NB-ARC PF00931.22 EDK38220.1 - 0.0096 15.1 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MeaB PF03308.16 EDK38220.1 - 0.012 14.6 0.0 0.028 13.4 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EDK38220.1 - 0.016 15.4 0.0 0.037 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDK38220.1 - 0.018 15.0 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 EDK38220.1 - 0.02 14.7 0.0 0.044 13.6 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 EDK38220.1 - 0.043 13.8 0.0 0.087 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EDK38220.1 - 0.053 13.2 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDK38220.1 - 0.058 13.9 0.0 0.098 13.2 0.0 1.5 1 1 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 EDK38220.1 - 0.066 13.3 0.1 0.15 12.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase CPT PF07931.12 EDK38220.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_14 PF13173.6 EDK38220.1 - 0.12 12.4 0.0 2.5 8.2 0.0 2.8 2 1 1 3 3 3 0 AAA domain WD40 PF00400.32 EDK38221.2 - 5.5e-28 96.6 17.2 5.1e-06 27.1 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38221.2 - 4.7e-15 55.7 0.4 0.013 15.8 0.0 5.8 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK38221.2 - 1.6e-07 31.4 0.3 0.024 14.5 0.1 4.0 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDK38221.2 - 3.1e-05 23.5 0.0 0.00022 20.7 0.0 2.1 1 1 2 3 3 3 1 WD40-like domain ARD PF03079.14 EDK38222.2 - 1e-38 133.0 0.3 1.2e-38 132.7 0.3 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EDK38222.2 - 1.3e-09 37.6 0.0 2.1e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EDK38222.2 - 3.8e-07 30.1 0.0 5.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EDK38222.2 - 0.00019 21.0 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EDK38222.2 - 0.011 15.4 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Prefoldin_2 PF01920.20 EDK38223.2 - 9.6e-16 57.7 5.1 9.6e-16 57.7 5.1 1.3 2 0 0 2 2 1 1 Prefoldin subunit Prefoldin PF02996.17 EDK38223.2 - 2.6e-06 27.3 4.0 6.6e-06 26.0 4.0 1.7 1 1 0 1 1 1 1 Prefoldin subunit Wtap PF17098.5 EDK38223.2 - 0.00017 21.5 2.8 0.00024 21.1 2.8 1.2 1 0 0 1 1 1 1 WTAP/Mum2p family COG2 PF06148.11 EDK38223.2 - 0.0047 17.0 3.1 1.2 9.3 0.2 2.1 1 1 1 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 Sipho_Gp157 PF05565.11 EDK38223.2 - 0.01 15.9 4.8 0.012 15.6 4.8 1.2 1 0 0 1 1 1 0 Siphovirus Gp157 DUF1640 PF07798.11 EDK38223.2 - 0.018 15.1 8.1 0.14 12.2 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) GCN5L1 PF06320.13 EDK38223.2 - 0.048 13.8 0.5 0.048 13.8 0.5 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) AAA_33 PF13671.6 EDK38223.2 - 0.064 13.4 0.1 0.1 12.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain Seryl_tRNA_N PF02403.22 EDK38223.2 - 0.12 12.7 7.2 2.5 8.4 0.2 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 EDK38223.2 - 0.12 12.2 0.1 0.12 12.2 0.1 2.5 2 1 0 2 2 2 0 Septum formation initiator DASH_Spc34 PF08657.10 EDK38223.2 - 0.15 11.9 4.0 0.18 11.6 4.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 FliD_N PF02465.18 EDK38223.2 - 0.17 12.6 8.8 0.22 12.2 2.6 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Rootletin PF15035.6 EDK38223.2 - 0.19 11.8 12.2 1.2 9.1 12.2 1.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ZapB PF06005.12 EDK38223.2 - 0.19 12.2 10.9 0.33 11.4 3.4 2.2 2 0 0 2 2 2 0 Cell division protein ZapB Cep57_CLD_2 PF14197.6 EDK38223.2 - 0.2 11.8 2.8 0.94 9.6 0.4 2.3 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Laminin_II PF06009.12 EDK38223.2 - 0.3 11.1 7.9 0.74 9.8 0.7 2.1 2 0 0 2 2 2 0 Laminin Domain II RmuC PF02646.16 EDK38223.2 - 0.3 10.2 8.1 1.9 7.5 1.2 2.0 2 0 0 2 2 2 0 RmuC family PSII_Pbs27 PF13326.6 EDK38223.2 - 0.31 11.4 3.1 0.89 9.9 0.5 2.0 2 0 0 2 2 2 0 Photosystem II Pbs27 DUF3010 PF11215.8 EDK38223.2 - 0.34 11.2 5.1 0.86 9.9 3.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3010) DUF4200 PF13863.6 EDK38223.2 - 0.35 11.3 11.4 1.1 9.7 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4446 PF14584.6 EDK38223.2 - 0.36 10.8 7.6 0.17 11.9 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) TPR_MLP1_2 PF07926.12 EDK38223.2 - 0.59 10.2 12.5 4 7.5 5.3 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.19 EDK38223.2 - 0.74 9.4 9.1 1.7 8.3 0.5 2.1 2 0 0 2 2 2 0 GrpE KxDL PF10241.9 EDK38223.2 - 0.77 10.1 8.2 1.7 9.0 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein Swi5 PF07061.11 EDK38223.2 - 0.79 9.9 6.3 2.5 8.2 0.9 2.5 1 1 1 2 2 2 0 Swi5 YabA PF06156.13 EDK38223.2 - 0.83 10.3 5.9 3.3 8.4 1.0 2.3 2 0 0 2 2 2 0 Initiation control protein YabA FAM184 PF15665.5 EDK38223.2 - 0.97 9.2 11.5 3.3 7.4 1.6 2.0 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Fib_alpha PF08702.10 EDK38223.2 - 1.3 9.2 9.0 4.3 7.5 0.9 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FapA PF03961.13 EDK38223.2 - 2.6 6.5 9.6 1.9 7.0 1.3 2.0 1 1 0 2 2 2 0 Flagellar Assembly Protein A SlyX PF04102.12 EDK38223.2 - 4.3 8.0 8.4 8.4 7.1 2.3 2.3 2 0 0 2 2 2 0 SlyX DUF16 PF01519.16 EDK38223.2 - 5.6 7.5 9.9 4.7 7.8 3.0 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 DDOST_48kD PF03345.14 EDK38225.2 - 1.1e-113 380.2 4.9 7.5e-113 377.5 4.9 1.9 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Nas2_N PF18265.1 EDK38226.2 - 4e-24 84.3 0.2 6.8e-24 83.6 0.2 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 EDK38226.2 - 1.1e-08 35.2 0.1 1.9e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EDK38226.2 - 5.5e-06 26.1 0.1 8.9e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EDK38226.2 - 1e-05 25.9 0.0 1.5e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 EDK38226.2 - 0.003 17.9 0.0 0.0054 17.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF2369 PF10179.9 EDK38226.2 - 0.015 15.7 0.1 0.084 13.3 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) Mur_ligase_C PF02875.21 EDK38226.2 - 0.11 12.8 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain CSG2 PF16965.5 EDK38227.2 - 2.7e-07 29.9 16.6 1.7e-05 24.0 16.6 2.3 1 1 0 1 1 1 1 Ceramide synthase regulator EamA PF00892.20 EDK38227.2 - 1.9e-06 28.1 44.8 2.6e-05 24.4 6.0 3.5 3 2 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EDK38227.2 - 1.7 7.8 14.8 6.6 5.8 14.8 2.0 1 1 0 1 1 1 0 Nucleotide-sugar transporter ADH_zinc_N PF00107.26 EDK38229.2 - 1.7e-12 47.4 0.2 3.8e-12 46.3 0.2 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK38229.2 - 5.8e-06 26.2 0.5 4.1e-05 23.4 0.2 2.3 1 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDK38229.2 - 0.0069 17.4 0.9 0.014 16.4 0.2 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Fe_hyd_lg_C PF02906.14 EDK38229.2 - 0.097 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain PRP38 PF03371.15 EDK38230.1 - 6.1e-47 159.7 0.8 6.9e-47 159.5 0.8 1.0 1 0 0 1 1 1 1 PRP38 family BAR_2 PF10455.9 EDK38231.2 - 3.4e-85 285.7 12.3 3.4e-85 285.7 12.3 1.6 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDK38231.2 - 2.3e-05 24.2 6.2 2.3e-05 24.2 6.2 2.1 2 1 1 3 3 3 1 BAR domain DUF2937 PF11157.8 EDK38231.2 - 0.11 12.3 0.3 0.22 11.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) HIP1_clath_bdg PF16515.5 EDK38231.2 - 4.5 7.9 10.9 0.9 10.2 2.5 3.0 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Arf PF00025.21 EDK38232.2 - 6.2e-37 126.7 1.3 3.8e-29 101.4 0.2 2.4 2 1 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 EDK38232.2 - 4.4e-13 49.1 0.1 6.9e-07 28.7 0.3 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EDK38232.2 - 6.7e-12 45.7 0.9 6.7e-10 39.2 0.3 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK38232.2 - 2e-09 37.2 0.1 9.6e-09 35.0 0.0 2.0 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 EDK38232.2 - 2.1e-07 30.6 0.0 0.00033 20.1 0.0 2.3 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDK38232.2 - 4.9e-06 26.1 0.1 3.4e-05 23.3 0.1 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDK38232.2 - 6.9e-05 22.5 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK38232.2 - 9.9e-05 22.4 0.0 0.00025 21.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EDK38232.2 - 0.024 15.2 0.0 0.031 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDK38232.2 - 0.11 11.9 0.0 0.32 10.4 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 EDK38232.2 - 0.12 12.0 0.2 3.1 7.3 0.1 2.5 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EDK38232.2 - 0.12 12.6 0.0 0.27 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain Collagen PF01391.18 EDK38233.2 - 2.4e-05 24.0 16.5 2.4e-05 24.0 16.5 15.5 15 2 2 17 17 17 3 Collagen triple helix repeat (20 copies) ABC_tran_CTD PF16326.5 EDK38233.2 - 1.7 8.9 4.7 0.34 11.2 0.5 1.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain Ribosomal_L29e PF01779.17 EDK38234.1 - 2.5e-21 75.7 15.0 3.2e-21 75.4 15.0 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Ribosomal_L7Ae PF01248.26 EDK38235.1 - 7.1e-23 80.2 0.6 1.2e-22 79.4 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EDK38235.1 - 0.0035 17.4 0.1 0.0056 16.8 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 EF-hand_like PF09279.11 EDK38235.1 - 0.092 13.2 0.2 0.42 11.1 0.1 2.0 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like PQ-loop PF04193.14 EDK38236.2 - 3.3e-29 100.4 3.4 1.8e-19 69.2 0.7 3.5 4 0 0 4 4 4 2 PQ loop repeat YrhC PF14143.6 EDK38236.2 - 0.055 13.6 1.1 0.14 12.3 0.1 2.2 2 0 0 2 2 2 0 YrhC-like protein UPF0640 PF15114.6 EDK38236.2 - 0.11 12.4 0.3 0.7 9.7 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0640 RseC_MucC PF04246.12 EDK38236.2 - 0.15 12.0 0.2 0.15 12.0 0.2 2.2 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC adh_short PF00106.25 EDK38237.2 - 9.6e-15 54.6 0.0 1.2e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK38237.2 - 4.6e-06 26.4 0.0 5.7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Caveolin PF01146.17 EDK38237.2 - 0.046 13.7 0.4 0.37 10.8 0.0 2.3 1 1 2 3 3 3 0 Caveolin Anp1 PF03452.14 EDK38238.1 - 5.9e-112 373.4 0.0 7.7e-112 373.0 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glyco_tranf_2_4 PF13704.6 EDK38238.1 - 0.04 14.4 0.9 0.1 13.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 TsaE PF02367.17 EDK38238.1 - 0.076 13.0 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SMC_N PF02463.19 EDK38239.2 - 3.7e-70 235.8 13.2 2.2e-67 226.7 13.2 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDK38239.2 - 9.1e-22 77.6 0.5 5.2e-21 75.1 0.1 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EDK38239.2 - 1.5e-16 61.5 3.1 1.5e-16 61.5 3.1 6.9 3 2 3 6 6 6 1 AAA domain AAA_21 PF13304.6 EDK38239.2 - 6.5e-08 32.7 0.8 4.8e-05 23.3 0.2 4.1 4 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDK38239.2 - 3.2e-06 27.1 24.2 3.2e-06 27.1 24.2 4.3 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EDK38239.2 - 4.8e-05 23.0 0.0 0.00014 21.6 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain EzrA PF06160.12 EDK38239.2 - 0.0023 16.2 32.5 0.0023 16.2 32.5 6.0 3 2 3 6 6 6 3 Septation ring formation regulator, EzrA Tropomyosin PF00261.20 EDK38239.2 - 0.0023 17.3 6.4 0.0023 17.3 6.4 8.1 2 2 4 6 6 6 2 Tropomyosin Plasmid_RAQPRD PF09686.10 EDK38239.2 - 9.4 6.5 16.2 6.2 7.1 0.8 5.1 4 0 0 4 4 4 0 Plasmid protein of unknown function (Plasmid_RAQPRD) RNB PF00773.19 EDK38240.2 - 4.7e-54 183.9 2.7 1.6e-53 182.2 0.1 2.5 2 0 0 2 2 2 1 RNB domain DUF2795 PF11387.8 EDK38240.2 - 0.2 11.9 0.3 1.4 9.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) CENP-H PF05837.12 EDK38240.2 - 3.1 8.2 5.5 12 6.3 5.5 2.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Flocculin_t3 PF13928.6 EDK38241.2 - 3.3e-26 91.5 62.2 2.3e-14 53.6 16.6 6.5 3 2 2 5 5 5 3 Flocculin type 3 repeat Flocculin_t3 PF13928.6 EDK38242.1 - 1.9e-32 111.5 114.2 9.9e-13 48.4 19.7 6.6 5 2 1 6 6 6 4 Flocculin type 3 repeat ecTbetaR2 PF08917.10 EDK38242.1 - 0.0082 16.1 14.4 2.5 8.1 4.0 4.1 1 1 1 3 3 3 2 Transforming growth factor beta receptor 2 ectodomain DUF4364 PF14277.6 EDK38242.1 - 0.35 10.6 2.7 1.3 8.8 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) FAD_binding_1 PF00667.20 EDK38243.2 - 2e-71 240.1 0.0 3.1e-71 239.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EDK38243.2 - 2.6e-08 34.5 0.0 7.6e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 EDK38243.2 - 0.018 15.3 0.6 0.062 13.6 0.1 2.1 2 0 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II FAD_binding_6 PF00970.24 EDK38243.2 - 0.083 13.3 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain FAD_binding_4 PF01565.23 EDK38244.2 - 1.3e-24 86.5 0.0 1.9e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Hpr_kinase_N PF02603.16 EDK38244.2 - 0.19 11.8 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase N terminus FAD-oxidase_C PF02913.19 EDK38245.2 - 1.4e-44 152.7 0.0 1.5e-44 152.5 0.0 1.0 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain YL1_C PF08265.11 EDK38246.2 - 3.5e-15 55.5 0.1 6.1e-15 54.7 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Sedlin_N PF04628.13 EDK38247.2 - 6.7e-12 45.7 0.1 9.3e-12 45.2 0.1 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EDK38247.2 - 0.045 13.7 0.0 0.052 13.5 0.0 1.1 1 0 0 1 1 1 0 Sybindin-like family Peptidase_M20 PF01546.28 EDK38248.2 - 7.2e-20 71.6 0.0 1e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK38248.2 - 1.5e-08 34.6 0.0 3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans PF04082.18 EDK38249.2 - 8.6e-17 61.0 0.3 1.6e-16 60.2 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EDK38250.2 - 7.3e-23 81.1 12.9 7.3e-23 81.1 12.9 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK38250.2 - 1.8e-07 30.4 17.8 3.2e-06 26.3 6.9 2.4 1 1 1 2 2 2 2 Sugar (and other) transporter Amidohydro_1 PF01979.20 EDK38251.1 - 5.1e-17 62.2 0.0 6.6e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family NTP_transf_2 PF01909.23 EDK38251.1 - 0.022 15.0 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Amidohydro_3 PF07969.11 EDK38251.1 - 0.094 12.2 0.0 0.21 11.0 0.0 1.5 2 0 0 2 2 2 0 Amidohydrolase family FAD_binding_3 PF01494.19 EDK38252.2 - 5.8e-25 88.3 0.0 7e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDK38252.2 - 3.2e-08 33.6 2.5 7.3e-05 22.5 2.8 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK38252.2 - 1.3e-06 27.7 3.3 2.3e-06 26.9 3.3 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EDK38252.2 - 3.5e-06 26.5 0.0 0.00037 19.8 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDK38252.2 - 5.3e-06 25.4 0.1 1.2e-05 24.3 0.1 1.5 1 1 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EDK38252.2 - 0.00022 20.4 0.9 0.0021 17.2 0.9 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EDK38252.2 - 0.00091 18.7 3.2 0.0015 18.0 3.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EDK38252.2 - 0.00095 18.4 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EDK38252.2 - 0.0012 19.3 0.6 0.016 15.7 0.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK38252.2 - 0.0018 18.5 0.8 0.0099 16.1 1.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDK38252.2 - 0.0068 15.7 0.8 0.011 15.0 0.8 1.3 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.24 EDK38252.2 - 0.036 13.4 0.3 2.9 7.1 0.3 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 EDK38252.2 - 0.11 11.8 0.7 0.19 11.0 0.7 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SIS_2 PF13580.6 EDK38252.2 - 0.17 11.9 0.5 4.3 7.4 0.2 2.6 3 0 0 3 3 3 0 SIS domain Trp_halogenase PF04820.14 EDK38252.2 - 0.24 10.2 4.1 0.76 8.6 2.8 2.1 1 1 1 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EDK38252.2 - 0.37 10.0 3.3 1.1 8.5 3.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase BAG PF02179.16 EDK38254.1 - 6.3e-24 84.2 2.2 1.2e-23 83.3 2.2 1.5 1 0 0 1 1 1 1 BAG domain AATF-Che1 PF13339.6 EDK38254.1 - 0.0082 16.8 1.1 0.01 16.5 0.3 1.5 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor Trimer_CC PF08954.11 EDK38254.1 - 0.028 14.0 1.5 0.069 12.7 0.7 2.0 2 0 0 2 2 2 0 Trimerisation motif O-ag_pol_Wzy PF14296.6 EDK38254.1 - 0.13 10.9 0.1 1.3 7.5 0.0 2.0 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy Sec61_beta PF03911.16 EDK38254.1 - 0.24 11.5 0.8 0.45 10.6 0.8 1.4 1 0 0 1 1 1 0 Sec61beta family DOPA_dioxygen PF08883.11 EDK38255.1 - 2.1e-34 117.9 0.1 2.6e-34 117.6 0.1 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Peptidase_M1 PF01433.20 EDK38256.2 - 1e-44 152.7 1.1 1.9e-44 151.8 1.1 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EDK38256.2 - 7.5e-31 106.5 0.1 2e-30 105.2 0.1 1.8 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EDK38256.2 - 7.6e-30 104.5 0.3 1.2e-29 103.8 0.3 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Sec31 PF11549.8 EDK38256.2 - 0.036 14.0 0.1 7.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein transport protein SEC31 Peptidase_M48 PF01435.18 EDK38256.2 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M48 Peptidase_M61 PF05299.12 EDK38256.2 - 0.73 10.2 2.9 15 6.0 2.9 2.5 1 1 0 1 1 1 0 M61 glycyl aminopeptidase DnaJ-X PF14308.6 EDK38257.2 - 5.3e-81 271.1 21.4 5.3e-81 271.1 21.4 3.3 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDK38257.2 - 1e-25 89.6 0.8 4.4e-25 87.6 0.8 2.2 1 0 0 1 1 1 1 DnaJ domain Ribosomal_S5_C PF03719.15 EDK38258.1 - 1.9e-25 88.1 0.1 6.1e-25 86.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EDK38258.1 - 2.1e-21 75.6 0.0 4e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF2838 PF10998.8 EDK38259.2 - 1.8e-37 128.0 15.2 1.8e-37 128.0 15.2 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) Fib_alpha PF08702.10 EDK38259.2 - 1.5 9.0 6.9 0.56 10.4 1.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Ax_dynein_light PF10211.9 EDK38259.2 - 4.5 7.2 8.5 1.8 8.5 3.8 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain DUF16 PF01519.16 EDK38259.2 - 9.9 6.7 11.6 2.4 8.7 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 MFS_1 PF07690.16 EDK38260.2 - 3.2e-13 49.3 27.1 3.2e-13 49.3 27.1 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily fn3 PF00041.21 EDK38261.2 - 5.9e-06 26.5 0.3 2.4e-05 24.6 0.3 2.0 1 0 0 1 1 1 1 Fibronectin type III domain fn3_2 PF16893.5 EDK38261.2 - 0.0028 17.8 0.1 0.011 15.8 0.1 2.1 1 0 0 1 1 1 1 Fibronectin type III domain CBM49 PF09478.10 EDK38261.2 - 0.0086 16.4 0.5 0.021 15.1 0.5 1.6 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 fn3_4 PF16794.5 EDK38261.2 - 0.042 13.8 0.0 0.37 10.7 0.0 2.4 1 1 0 1 1 1 0 Fibronectin-III type domain BLOC1S3 PF15753.5 EDK38261.2 - 0.7 10.0 10.5 1.5 9.0 10.5 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 PRF PF06875.11 EDK38261.2 - 1.6 8.1 6.1 0.63 9.4 0.1 2.9 3 1 0 3 3 3 0 Plethodontid receptivity factor PRF COG2 PF06148.11 EDK38261.2 - 2.2 8.4 11.9 0.65 10.1 3.0 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4407 PF14362.6 EDK38261.2 - 2.7 7.3 15.2 3.8 6.8 14.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 EDK38261.2 - 3.3 7.1 21.9 0.28 10.6 5.6 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 EDK38261.2 - 5.5 6.5 8.9 11 5.4 8.9 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Myb_DNA-bind_4 PF13837.6 EDK38261.2 - 5.8 7.4 9.6 4 7.9 5.8 2.4 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain CENP-F_leu_zip PF10473.9 EDK38261.2 - 6.9 6.7 24.3 4.6 7.3 19.1 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Beta_elim_lyase PF01212.21 EDK38262.1 - 2.9e-81 273.0 0.0 3.5e-81 272.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDK38262.1 - 1.5e-05 24.3 0.0 2.6e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDK38262.1 - 0.068 12.5 0.0 0.16 11.2 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.16 EDK38263.2 - 7.8e-36 123.7 24.3 7.8e-36 123.7 24.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK38263.2 - 4.9e-14 52.0 13.5 7.8e-14 51.4 13.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EDK38263.2 - 0.00012 20.7 1.4 0.0002 20.0 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) 7TM_GPCR_Srh PF10318.9 EDK38263.2 - 8.3 5.3 13.8 0.3 10.1 2.1 3.0 4 0 0 4 4 4 0 Serpentine type 7TM GPCR chemoreceptor Srh Alk_phosphatase PF00245.20 EDK38264.2 - 7.4e-113 377.6 0.0 8.8e-113 377.4 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EDK38264.2 - 5.2e-05 22.7 0.0 0.00018 20.9 0.0 1.8 2 0 0 2 2 2 1 Metalloenzyme superfamily OCD_Mu_crystall PF02423.15 EDK38265.2 - 2.7e-09 36.4 0.1 1e-08 34.5 0.1 1.7 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EDK38265.2 - 0.00016 21.7 0.3 0.00041 20.4 0.0 2.0 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Peptidase_C1_2 PF03051.15 EDK38265.2 - 0.053 12.3 0.0 0.08 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase C1-like family SoPB_HTH PF18090.1 EDK38265.2 - 0.088 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Centromere-binding protein HTH domain DUF4298 PF14131.6 EDK38266.2 - 0.23 11.4 2.8 0.81 9.7 1.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) Gpi1 PF05024.15 EDK38267.2 - 9.2e-66 221.5 7.9 9.2e-66 221.5 7.9 2.1 3 0 0 3 3 3 1 N-acetylglucosaminyl transferase component (Gpi1) Frtz PF11768.8 EDK38269.2 - 0.11 10.8 0.1 0.14 10.5 0.1 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz MFS_1 PF07690.16 EDK38270.2 - 1.6e-10 40.5 8.9 3.4e-10 39.4 8.6 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Colicin_V PF02674.16 EDK38270.2 - 0.72 9.8 8.3 9 6.3 0.2 2.5 2 0 0 2 2 2 0 Colicin V production protein MFS_1 PF07690.16 EDK38271.2 - 4.5e-10 39.0 30.3 2.3e-08 33.3 11.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S2 PF00318.20 EDK38272.1 - 6.1e-24 84.5 0.3 3.7e-14 52.5 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EDK38272.1 - 0.0037 18.6 14.4 0.013 16.8 14.4 2.0 1 1 0 1 1 1 1 40S ribosomal protein SA C-terminus SMI1_KNR4 PF09346.10 EDK38273.2 - 1.8e-38 131.9 0.0 7.6e-38 129.9 0.0 2.0 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) DIE2_ALG10 PF04922.12 EDK38274.2 - 6.7e-110 368.1 27.3 1.5e-109 366.9 27.3 1.5 1 1 0 1 1 1 1 DIE2/ALG10 family UPF0014 PF03649.13 EDK38274.2 - 5 6.4 9.2 6.9 5.9 2.3 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0014) WD40 PF00400.32 EDK38275.2 - 0.051 14.5 0.2 19 6.4 0.0 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat WD40 PF00400.32 EDK38276.2 - 4.7e-08 33.6 4.8 0.016 16.1 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38276.2 - 8.6e-05 22.8 0.2 0.68 10.3 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LVIVD PF08309.11 EDK38276.2 - 0.13 11.6 0.1 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 LVIVD repeat SH3_1 PF00018.28 EDK38277.2 - 1.8e-11 43.5 0.1 3.3e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDK38277.2 - 2.5e-10 39.9 0.0 3.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDK38277.2 - 1.9e-09 37.2 0.1 1.9e-09 37.2 0.1 1.9 3 0 0 3 3 3 1 Variant SH3 domain DMSP_lyase PF16867.5 EDK38277.2 - 0.059 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Band_7 PF01145.25 EDK38278.1 - 3.7e-21 75.9 2.8 5.9e-21 75.3 2.8 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF3416 PF11896.8 EDK38278.1 - 0.021 15.1 0.9 0.039 14.2 1.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) Lectin_C PF00059.21 EDK38279.2 - 0.22 12.3 2.8 0.7 10.6 0.4 2.7 3 0 0 3 3 3 0 Lectin C-type domain UvrD-helicase PF00580.21 EDK38280.2 - 5.5e-57 193.7 1.0 5.5e-57 193.7 1.0 3.1 2 2 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EDK38280.2 - 8.8e-57 193.1 0.1 5e-56 190.6 0.1 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EDK38280.2 - 8.7e-29 100.7 0.0 3.5e-28 98.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EDK38280.2 - 1.3e-09 37.7 0.4 1.8e-08 34.1 0.4 2.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 EDK38280.2 - 1.7e-08 34.6 0.1 1.7e-08 34.6 0.1 2.2 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EDK38280.2 - 1.1e-06 28.5 0.0 9.6e-05 22.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDK38280.2 - 0.001 19.0 0.0 0.016 15.1 0.0 2.6 2 0 0 2 2 2 1 Helicase AAA_12 PF13087.6 EDK38280.2 - 0.0026 17.4 0.0 2.1 7.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EDK38280.2 - 0.0028 17.5 1.1 6 6.5 0.1 3.7 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EDK38280.2 - 0.02 14.7 0.0 0.058 13.2 0.0 1.8 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK38280.2 - 0.05 13.9 4.4 2.1 8.6 0.1 3.4 3 1 1 4 4 4 0 AAA domain Rho_GDI PF02115.17 EDK38281.2 - 1.6e-57 194.4 0.9 1.7e-57 194.3 0.9 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Ufd2P_core PF10408.9 EDK38282.2 - 1.3e-202 674.8 3.3 1.7e-202 674.5 3.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EDK38282.2 - 8.2e-27 93.2 1.7 3.4e-26 91.2 1.3 2.3 2 0 0 2 2 2 1 U-box domain Arf PF00025.21 EDK38283.1 - 3.2e-80 267.7 0.0 3.9e-80 267.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDK38283.1 - 1.6e-14 54.1 0.0 2.1e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDK38283.1 - 3.3e-14 52.7 0.0 4.1e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDK38283.1 - 3.1e-13 49.7 0.0 3.3e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDK38283.1 - 1.5e-12 47.4 1.0 9.1e-09 34.9 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDK38283.1 - 1.5e-10 40.8 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK38283.1 - 3.6e-06 27.0 0.0 5.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDK38283.1 - 0.0054 16.1 0.5 0.012 15.0 0.5 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase LIAS_N PF16881.5 EDK38284.2 - 1.8e-20 73.3 0.4 5.3e-20 71.8 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EDK38284.2 - 1.2e-12 48.6 0.0 1.8e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 EDK38284.2 - 0.14 12.3 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal NUDIX PF00293.28 EDK38285.1 - 1.3e-21 77.0 0.0 2e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NINJA_B PF16136.5 EDK38286.2 - 0.023 15.0 2.8 0.023 15.0 2.8 3.4 3 1 0 3 3 3 0 Putative nuclear localisation signal CRT10 PF08728.10 EDK38286.2 - 2 6.5 9.1 2.6 6.1 9.1 1.1 1 0 0 1 1 1 0 CRT10 TraF_2 PF13729.6 EDK38286.2 - 2 7.7 5.1 2.7 7.3 0.6 2.5 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein Methyltrn_RNA_3 PF02598.17 EDK38287.2 - 1.5e-68 231.4 0.1 1.8e-68 231.1 0.1 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase OapA PF04225.12 EDK38287.2 - 0.036 14.2 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain PRONE PF03759.13 EDK38287.2 - 0.16 10.7 0.1 0.24 10.2 0.1 1.2 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) Glyco_hydro_17 PF00332.18 EDK38288.2 - 5.4e-87 292.3 5.4 6.3e-87 292.1 5.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Glyco_hydro_16 PF00722.21 EDK38289.2 - 1.8e-46 157.8 0.3 1.8e-46 157.8 0.3 2.5 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 RIFIN PF02009.16 EDK38289.2 - 8.6 6.1 7.2 14 5.4 7.2 1.4 1 0 0 1 1 1 0 Rifin SPRY PF00622.28 EDK38290.2 - 6.3e-13 48.9 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain DUF3445 PF11927.8 EDK38292.2 - 2.2e-68 230.3 0.3 2.6e-68 230.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) SH3_1 PF00018.28 EDK38293.2 - 1.5e-23 82.1 6.9 1.2e-12 47.3 0.6 2.7 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 EDK38293.2 - 4.5e-23 81.3 0.0 9.1e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_9 PF14604.6 EDK38293.2 - 5.5e-20 71.0 9.3 1.9e-10 40.4 0.5 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 EDK38293.2 - 2.9e-13 49.3 0.5 2.5e-06 27.1 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain DUF5470 PF17564.2 EDK38293.2 - 7.7 6.8 7.9 0.67 10.2 0.3 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5470) DNA_pol_phi PF04931.13 EDK38293.2 - 8.5 4.3 7.2 14 3.6 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi zf-UBR PF02207.20 EDK38294.2 - 1.4e-16 60.4 10.4 1.4e-16 60.4 10.4 2.2 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) zf-RING_2 PF13639.6 EDK38294.2 - 0.024 14.9 0.3 0.024 14.9 0.3 4.5 3 1 1 4 4 4 0 Ring finger domain FAST_1 PF06743.15 EDK38294.2 - 0.36 10.8 2.5 1.8 8.6 2.5 2.3 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 zf-rbx1 PF12678.7 EDK38295.2 - 0.00088 19.5 0.5 0.0025 18.1 0.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDK38295.2 - 0.0021 18.4 1.6 0.0021 18.4 1.6 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EDK38295.2 - 0.0023 17.8 1.8 0.0078 16.1 1.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK38295.2 - 0.0037 17.1 1.6 0.0096 15.8 1.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK38295.2 - 0.013 15.3 0.6 0.013 15.3 0.6 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDK38295.2 - 0.015 15.2 1.1 0.015 15.2 1.1 2.5 3 0 0 3 3 3 0 zinc-RING finger domain UAA PF08449.11 EDK38295.2 - 0.098 11.8 0.0 0.26 10.5 0.0 1.6 2 0 0 2 2 2 0 UAA transporter family zf-CpG_bind_C PF12269.8 EDK38295.2 - 2.2 8.0 5.3 5.3 6.8 0.3 2.4 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain zf-UBR PF02207.20 EDK38296.2 - 3.1e-17 62.5 11.9 5.4e-17 61.7 11.9 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EDK38296.2 - 1.6e-06 27.8 0.0 6.6e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS tRNA-synt_1b PF00579.25 EDK38297.1 - 9.3e-73 245.1 0.0 1.3e-72 244.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) SBDS PF01172.18 EDK38298.1 - 9.3e-35 118.6 1.0 1.8e-34 117.6 1.0 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EDK38298.1 - 2.2e-30 105.1 4.4 2.2e-30 105.1 4.4 1.6 2 0 0 2 2 2 1 SBDS protein C-terminal domain DUF4706 PF15797.5 EDK38298.1 - 0.097 13.2 2.8 0.17 12.4 0.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4706) RAC_head PF16717.5 EDK38299.2 - 7e-25 87.9 5.4 7e-25 87.9 5.4 3.1 2 1 1 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 EDK38299.2 - 5.4e-17 61.7 0.1 1.5e-16 60.3 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain Acyl-CoA_dh_1 PF00441.24 EDK38299.2 - 0.033 14.4 4.3 0.056 13.6 4.3 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain IPP-2 PF04979.14 EDK38300.2 - 2.2e-21 77.0 8.2 2.2e-21 77.0 8.2 2.0 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Arf PF00025.21 EDK38301.1 - 1.9e-75 252.2 0.3 2.1e-75 252.0 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDK38301.1 - 2.4e-16 60.0 0.0 3.2e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDK38301.1 - 3.4e-12 46.2 0.0 4e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDK38301.1 - 1.8e-10 40.7 0.0 2e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDK38301.1 - 2.6e-10 40.0 0.5 4.1e-06 26.2 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDK38301.1 - 2.8e-10 39.9 0.0 3.5e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK38301.1 - 0.00011 22.3 0.0 0.00018 21.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EDK38301.1 - 0.0012 17.9 0.9 0.033 13.2 0.2 2.5 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EDK38301.1 - 0.0019 18.7 0.4 0.0067 16.9 0.4 1.8 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EDK38301.1 - 0.043 14.4 0.2 0.056 14.0 0.2 1.6 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 EDK38301.1 - 0.093 12.3 1.3 8.7 5.9 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EDK38301.1 - 0.095 12.3 0.6 0.64 9.6 0.1 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PDH PF02153.17 EDK38303.2 - 5.3e-14 51.8 0.0 7.1e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EDK38303.2 - 3.7e-07 30.6 0.0 7.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EDK38303.2 - 2.4e-06 27.0 0.0 4.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EDK38303.2 - 9.9e-06 25.8 0.0 1.8e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EDK38303.2 - 0.00052 19.7 0.0 0.00091 18.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 EDK38303.2 - 0.0071 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 EDK38303.2 - 0.021 14.7 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDK38303.2 - 0.025 14.6 0.0 0.069 13.2 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EDK38303.2 - 0.059 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.9 EDK38303.2 - 0.072 13.0 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain TrkA_N PF02254.18 EDK38303.2 - 0.083 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GHMP_kinases_N PF00288.26 EDK38304.2 - 5.5e-08 32.9 0.4 1.8e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain Spatacsin_C PF14649.6 EDK38304.2 - 0.05 12.7 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Spatacsin C-terminus PsaL PF02605.15 EDK38304.2 - 0.093 12.4 0.1 0.27 10.9 0.0 1.9 2 1 1 3 3 3 0 Photosystem I reaction centre subunit XI GHMP_kinases_C PF08544.13 EDK38305.2 - 1.9e-08 34.5 0.0 4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal FAST_1 PF06743.15 EDK38305.2 - 0.041 13.8 0.0 0.54 10.2 0.0 2.7 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 GHMP_kinases_N PF00288.26 EDK38305.2 - 0.091 13.0 0.0 0.3 11.3 0.0 1.8 2 0 0 2 2 2 0 GHMP kinases N terminal domain Neugrin PF06413.11 EDK38305.2 - 0.15 12.0 0.1 0.36 10.8 0.1 1.6 2 0 0 2 2 2 0 Neugrin DUF4448 PF14610.6 EDK38307.2 - 0.13 12.0 0.3 0.95 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Peptidase_M20 PF01546.28 EDK38308.2 - 6.8e-31 107.6 0.0 1e-30 107.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK38308.2 - 2.7e-12 46.6 0.0 5.8e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain TFIID-31kDa PF02291.15 EDK38308.2 - 0.031 14.3 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Peptidase_M28 PF04389.17 EDK38308.2 - 0.035 13.8 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 VWA_N PF08399.11 EDK38308.2 - 0.044 14.3 0.0 0.094 13.2 0.0 1.5 1 0 0 1 1 1 0 VWA N-terminal DUF383 PF04063.14 EDK38309.1 - 1.6e-70 236.7 1.3 1.4e-69 233.6 0.3 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EDK38309.1 - 0.00012 21.9 0.7 0.00029 20.6 0.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) TFIIF_alpha PF05793.12 EDK38310.2 - 3e-22 78.9 28.1 7.9e-12 44.5 12.9 3.2 1 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Vac7 PF12751.7 EDK38310.2 - 0.019 14.4 4.4 0.032 13.7 3.7 1.7 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 CAML PF14963.6 EDK38310.2 - 0.3 11.2 7.9 0.61 10.2 7.9 1.5 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Adeno_PV PF03910.13 EDK38310.2 - 0.35 9.5 2.4 0.62 8.7 2.4 1.4 1 0 0 1 1 1 0 Adenovirus minor core protein PV Mito_carr PF00153.27 EDK38311.1 - 2.1e-53 178.2 1.2 4.4e-17 61.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF5572 PF17733.1 EDK38312.2 - 1.4e-22 79.3 1.8 4.3e-22 77.7 1.8 1.9 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Mannosyl_trans PF05007.13 EDK38313.2 - 3.9e-75 253.1 25.6 6.2e-75 252.4 25.6 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EDK38313.2 - 2.4e-14 53.2 8.7 2.4e-14 53.2 8.7 2.1 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EDK38313.2 - 3.5e-05 23.7 9.1 3.5e-05 23.7 9.1 2.5 1 1 1 2 2 2 1 Glycosyltransferase family 87 RNase_PH PF01138.21 EDK38314.2 - 4.8e-31 108.0 0.4 6.3e-31 107.6 0.4 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDK38314.2 - 4.9e-06 26.5 0.1 9.5e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF4242 PF14026.6 EDK38314.2 - 0.11 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) SURF4 PF02077.15 EDK38315.2 - 7e-91 304.5 12.7 8e-91 304.3 12.7 1.0 1 0 0 1 1 1 1 SURF4 family VirB8 PF04335.13 EDK38315.2 - 0.091 12.6 0.5 0.2 11.5 0.5 1.5 1 0 0 1 1 1 0 VirB8 protein HR_lesion PF05514.11 EDK38315.2 - 2.8 8.1 16.0 0.15 12.3 9.4 2.4 3 0 0 3 3 3 0 HR-like lesion-inducing zf-Tim10_DDP PF02953.15 EDK38316.2 - 3.4e-19 68.2 3.7 4.7e-19 67.8 3.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Kelch_6 PF13964.6 EDK38317.2 - 1.4e-06 28.4 1.5 3.1 8.2 0.0 5.6 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EDK38317.2 - 0.0094 15.9 0.1 0.0094 15.9 0.1 5.2 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EDK38317.2 - 0.013 15.8 0.1 4.4 7.7 0.0 4.6 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EDK38317.2 - 0.05 13.6 5.3 0.64 10.1 0.0 5.1 7 0 0 7 7 7 0 Kelch motif Kelch_1 PF01344.25 EDK38317.2 - 0.098 12.3 1.5 3.1 7.5 0.0 3.5 3 0 0 3 3 3 0 Kelch motif ABC1 PF03109.16 EDK38318.2 - 1.7e-22 79.8 0.1 2.8e-14 53.3 0.0 2.6 2 0 0 2 2 2 2 ABC1 family RIO1 PF01163.22 EDK38318.2 - 0.00085 19.0 0.1 0.0022 17.6 0.1 1.7 1 0 0 1 1 1 1 RIO1 family Aldedh PF00171.22 EDK38319.1 - 5e-177 589.0 0.3 5.6e-177 588.9 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDK38319.1 - 0.034 13.6 0.1 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DUF2188 PF09954.9 EDK38319.1 - 0.16 12.1 0.0 0.43 10.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) SNF2_N PF00176.23 EDK38320.2 - 2.4e-52 177.8 0.0 6.1e-52 176.5 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK38320.2 - 3.2e-15 56.4 0.0 7.3e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EDK38320.2 - 3.8e-07 29.9 10.5 3.8e-07 29.9 10.5 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EDK38320.2 - 1e-06 28.9 0.0 2.1e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK38320.2 - 2.6e-05 24.1 0.0 5.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 EDK38320.2 - 0.00096 18.9 11.0 0.00096 18.9 11.0 2.4 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK38320.2 - 0.0034 17.2 9.3 0.0034 17.2 9.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK38320.2 - 0.015 15.3 8.0 0.015 15.3 8.0 2.1 3 0 0 3 3 2 0 RING-type zinc-finger PSY3 PF16836.5 EDK38320.2 - 0.095 12.2 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description Zn_Tnp_IS91 PF14319.6 EDK38320.2 - 5.2 7.2 11.9 6.6 6.8 4.3 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-C3HC4_4 PF15227.6 EDK38320.2 - 9.6 6.5 21.5 0.03 14.5 10.9 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING WD40 PF00400.32 EDK38321.2 - 1e-19 70.5 2.7 2e-05 25.2 0.2 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38321.2 - 1.4e-08 34.9 0.0 0.13 12.6 0.0 5.1 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EDK38321.2 - 0.053 13.1 0.0 0.092 12.3 0.0 1.4 1 1 0 1 1 1 0 PQQ-like domain GATase_3 PF07685.14 EDK38321.2 - 0.08 12.5 0.0 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain SdiA-regulated PF06977.11 EDK38321.2 - 0.1 11.8 0.0 4.8 6.3 0.0 2.5 3 0 0 3 3 3 0 SdiA-regulated DLH PF01738.18 EDK38323.2 - 2e-31 109.2 0.0 2.5e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EDK38323.2 - 0.002 18.1 0.1 0.0084 16.1 0.1 1.8 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 EDK38323.2 - 0.0037 16.9 0.0 0.0052 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Peptidase_S15 PF02129.18 EDK38323.2 - 0.033 13.8 0.0 0.041 13.5 0.0 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EDK38323.2 - 0.035 13.6 0.0 0.091 12.2 0.0 1.8 1 1 1 2 2 2 0 Prolyl oligopeptidase family ArsA_ATPase PF02374.15 EDK38324.2 - 2.1e-107 358.8 0.1 2.5e-107 358.6 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EDK38324.2 - 4.2e-08 33.3 1.7 9.5e-08 32.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EDK38324.2 - 1.3e-07 31.7 0.8 4.2e-07 30.1 0.5 2.1 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EDK38324.2 - 0.00012 21.6 3.5 0.0092 15.5 1.4 2.7 2 1 1 3 3 3 2 NUBPL iron-transfer P-loop NTPase NB-ARC PF00931.22 EDK38324.2 - 0.0029 16.8 0.0 0.011 15.0 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain Fer4_NifH PF00142.18 EDK38324.2 - 0.0071 15.8 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_24 PF13479.6 EDK38324.2 - 0.028 14.1 0.5 0.29 10.8 0.2 2.4 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDK38324.2 - 0.029 13.7 0.0 0.07 12.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin SRP54 PF00448.22 EDK38324.2 - 0.03 14.0 0.1 0.15 11.7 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.12 EDK38324.2 - 0.085 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SPX PF03105.19 EDK38325.2 - 3.7e-49 168.6 15.7 5.5e-49 168.1 15.7 1.3 1 0 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.6 EDK38325.2 - 1.3e-08 34.8 9.3 1.3e-08 34.8 9.3 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDK38325.2 - 1.9e-08 34.5 9.1 3.9e-08 33.5 9.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDK38325.2 - 5.1e-08 32.7 8.8 9.1e-08 31.8 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK38325.2 - 2e-07 30.7 9.5 4.5e-07 29.6 9.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK38325.2 - 3.4e-07 30.0 9.8 3.4e-07 30.0 9.8 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK38325.2 - 4.6e-07 29.7 7.4 2e-06 27.7 7.6 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDK38325.2 - 3.2e-05 23.8 10.2 0.00025 20.9 10.7 2.1 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDK38325.2 - 0.00037 20.3 9.8 0.0018 18.1 10.2 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EDK38325.2 - 0.0025 17.6 3.5 0.0025 17.6 3.5 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EDK38325.2 - 0.012 15.7 4.9 0.029 14.5 4.9 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EDK38325.2 - 0.048 13.9 6.8 0.14 12.4 6.8 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain Mor PF08765.11 EDK38325.2 - 0.052 13.5 0.6 1 9.4 0.0 2.9 3 0 0 3 3 3 0 Mor transcription activator family zf-ANAPC11 PF12861.7 EDK38325.2 - 0.07 13.2 2.3 0.14 12.2 2.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Spore_III_AB PF09548.10 EDK38325.2 - 0.21 11.7 1.6 0.59 10.2 0.2 2.5 2 2 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) DUF2185 PF09951.9 EDK38325.2 - 0.28 11.1 2.1 0.85 9.5 0.1 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2185) zf-RING_6 PF14835.6 EDK38325.2 - 0.44 10.5 3.1 0.96 9.4 3.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn-ribbon_8 PF09723.10 EDK38325.2 - 0.62 10.2 3.1 0.95 9.6 1.4 2.1 2 0 0 2 2 2 0 Zinc ribbon domain GAGA PF09237.11 EDK38325.2 - 0.86 9.5 3.0 10 6.0 0.5 2.5 2 0 0 2 2 2 0 GAGA factor ThiF PF00899.21 EDK38326.2 - 2.2e-18 66.5 0.0 3.6e-18 65.8 0.0 1.4 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EDK38326.2 - 0.0016 18.6 0.0 0.86 9.8 0.0 2.7 2 0 0 2 2 2 2 Ubiquitin-activating enzyme E1 four-helix bundle DEAD PF00270.29 EDK38327.2 - 2.5e-42 144.6 0.1 1.8e-41 141.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK38327.2 - 1.3e-24 86.7 0.0 6.6e-24 84.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDK38327.2 - 1.5e-19 70.0 0.3 3e-19 69.0 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDK38327.2 - 9.3e-06 25.7 0.9 2.3e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EDK38327.2 - 0.0056 16.2 3.4 1.3 8.5 0.0 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EDK38327.2 - 0.14 12.4 0.6 0.83 9.9 0.6 2.2 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDK38327.2 - 0.44 10.3 5.7 0.26 11.0 1.6 2.4 3 0 0 3 3 3 0 AAA domain CRA PF06589.11 EDK38327.2 - 1 9.5 12.2 2.1 8.4 12.2 1.5 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) TSP_NTD PF17804.1 EDK38327.2 - 5.7 7.1 11.7 11 6.2 11.7 1.4 1 0 0 1 1 1 0 Tail specific protease N-terminal domain DUF1168 PF06658.12 EDK38327.2 - 7.2 6.4 20.6 13 5.6 20.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PseudoU_synth_1 PF01416.20 EDK38328.2 - 4.5e-35 120.4 0.0 6.3e-32 110.3 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase EAP30 PF04157.16 EDK38329.2 - 1.6e-48 165.1 0.0 1.9e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Y_phosphatase3 PF13350.6 EDK38330.2 - 8.4e-61 205.9 0.0 1.3e-60 205.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Hydrolase_4 PF12146.8 EDK38330.2 - 4.8e-07 29.3 0.0 0.00026 20.3 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Y_phosphatase2 PF03162.13 EDK38330.2 - 3.2e-06 26.8 0.0 6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_1 PF00561.20 EDK38330.2 - 1.5e-05 24.8 0.2 0.0037 17.0 0.0 2.7 3 0 0 3 3 3 1 alpha/beta hydrolase fold Y_phosphatase PF00102.27 EDK38330.2 - 6.4e-05 22.6 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Abhydrolase_6 PF12697.7 EDK38330.2 - 9.1e-05 23.2 0.0 0.0002 22.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Myotub-related PF06602.14 EDK38330.2 - 0.0037 16.2 0.0 0.0056 15.7 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EDK38330.2 - 0.004 17.0 0.1 0.015 15.1 0.1 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Peptidase_S9 PF00326.21 EDK38330.2 - 0.0096 15.4 0.0 0.56 9.7 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF1749 PF08538.10 EDK38330.2 - 0.01 15.0 0.0 0.023 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) PTPlike_phytase PF14566.6 EDK38330.2 - 0.012 15.7 0.1 0.025 14.7 0.1 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF2202 PF09968.9 EDK38330.2 - 0.075 12.9 0.2 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) Methyltrn_RNA_2 PF04013.12 EDK38330.2 - 0.12 12.1 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase Ctf8 PF09696.10 EDK38331.2 - 1.8e-29 102.9 0.2 3.8e-28 98.6 0.2 2.0 1 1 0 1 1 1 1 Ctf8 Poxvirus_B22R_C PF13168.6 EDK38331.2 - 0.021 14.3 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal DUF3112 PF11309.8 EDK38332.1 - 1.1e-97 325.8 1.3 1.1e-97 325.8 1.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3112) DUF4271 PF14093.6 EDK38332.1 - 0.065 13.1 14.9 0.34 10.8 2.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) DUF3112 PF11309.8 EDK38333.1 - 2e-53 181.1 6.1 2e-53 181.1 6.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3112) CytB6-F_Fe-S PF08802.10 EDK38333.1 - 5 7.2 6.1 3 7.9 2.9 2.3 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit DUF3112 PF11309.8 EDK38334.2 - 4.1e-39 134.3 1.8 5.9e-39 133.8 1.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3112) Chs7 PF12271.8 EDK38334.2 - 0.0065 15.9 1.3 0.0083 15.5 1.3 1.1 1 0 0 1 1 1 1 Chitin synthase export chaperone Pyr_redox_2 PF07992.14 EDK38335.2 - 4.9e-47 160.6 0.0 6e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK38335.2 - 3.2e-09 37.2 0.1 4.4e-08 33.6 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK38335.2 - 0.0046 16.3 0.2 0.42 9.8 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EDK38335.2 - 0.071 13.4 0.1 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Mod_r PF07200.13 EDK38336.2 - 1.4e-20 73.9 12.8 1.7e-20 73.6 12.8 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF148 PF02520.17 EDK38336.2 - 0.0083 16.2 3.8 0.0083 16.2 3.8 2.1 1 1 1 2 2 2 1 Domain of unknown function DUF148 Spore_II_R PF09551.10 EDK38336.2 - 0.012 16.0 3.5 0.017 15.6 3.2 1.4 1 1 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) DUF948 PF06103.11 EDK38336.2 - 0.019 15.2 1.3 0.032 14.5 0.3 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SecA_DEAD PF07517.14 EDK38336.2 - 0.037 13.3 2.2 0.034 13.4 1.3 1.3 1 1 0 1 1 1 0 SecA DEAD-like domain DHR10 PF18595.1 EDK38336.2 - 0.041 14.0 2.2 0.041 14.0 2.2 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF3410 PF11890.8 EDK38336.2 - 0.042 13.7 0.2 0.1 12.4 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) Med9 PF07544.13 EDK38336.2 - 0.054 13.6 0.8 0.054 13.6 0.8 2.7 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF745 PF05335.13 EDK38336.2 - 0.059 13.1 2.8 0.077 12.7 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.11 EDK38336.2 - 0.07 13.7 4.9 5.4 7.6 0.6 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Laminin_II PF06009.12 EDK38336.2 - 0.088 12.8 2.0 0.69 9.9 0.5 2.1 2 0 0 2 2 2 0 Laminin Domain II HBM PF16591.5 EDK38336.2 - 0.099 12.0 5.8 0.13 11.7 4.0 1.9 1 1 1 2 2 2 0 Helical bimodular sensor domain DUF4298 PF14131.6 EDK38336.2 - 0.11 12.5 7.9 2 8.4 4.9 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4298) THP2 PF09432.10 EDK38336.2 - 0.14 12.2 5.9 0.44 10.6 0.2 2.2 1 1 1 2 2 2 0 Tho complex subunit THP2 ABC2_membrane_3 PF12698.7 EDK38336.2 - 0.19 10.8 1.4 0.22 10.6 1.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-C4H2 PF10146.9 EDK38336.2 - 0.19 12.0 8.5 0.69 10.2 8.5 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein CENP-H PF05837.12 EDK38336.2 - 0.38 11.2 3.8 0.29 11.5 1.6 1.8 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Prominin PF05478.11 EDK38336.2 - 2.2 6.1 8.6 4.6 5.1 2.2 2.0 1 1 1 2 2 2 0 Prominin MFS_1 PF07690.16 EDK38337.2 - 2e-38 132.2 29.6 2e-38 132.2 29.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK38337.2 - 1.6e-05 23.6 2.9 2.2e-05 23.1 2.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FPN1 PF06963.12 EDK38337.2 - 0.011 14.4 0.2 0.011 14.4 0.2 1.9 2 0 0 2 2 2 0 Ferroportin1 (FPN1) DUF3589 PF12141.8 EDK38338.2 - 1.2e-127 426.5 0.0 9.4e-67 225.7 0.0 2.0 1 1 1 2 2 2 2 Beta-mannosyltransferases Ank_4 PF13637.6 EDK38339.2 - 2.3e-14 53.5 0.2 8.2e-05 23.1 0.0 4.4 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDK38339.2 - 8.4e-12 45.5 1.2 1.1e-05 26.0 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDK38339.2 - 1.1e-09 37.6 1.5 0.0073 16.7 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EDK38339.2 - 1.8e-07 31.3 0.0 0.55 10.8 0.1 4.6 3 1 1 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 EDK38339.2 - 3.4e-06 26.9 0.1 3.4e-06 26.9 0.1 3.0 3 1 0 3 3 3 1 KilA-N domain Ank_5 PF13857.6 EDK38339.2 - 4.2e-06 26.9 1.1 0.12 12.7 0.1 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) ABC_tran_Xtn PF12848.7 EDK38339.2 - 0.27 11.3 3.5 0.76 9.9 3.5 1.8 1 0 0 1 1 1 0 ABC transporter Exonuc_VII_L PF02601.15 EDK38339.2 - 1.3 8.6 7.3 2.6 7.5 7.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit TFIIA PF03153.13 EDK38339.2 - 1.5 8.7 16.5 0.023 14.7 3.9 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Rho_GDI PF02115.17 EDK38340.2 - 0.063 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor zinc_ribbon_10 PF10058.9 EDK38341.2 - 2.5e-20 71.9 0.1 4.5e-20 71.1 0.1 1.5 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein NAC PF01849.18 EDK38342.1 - 1.6e-18 66.4 0.2 2.7e-18 65.7 0.2 1.4 1 0 0 1 1 1 1 NAC domain PGA2 PF07543.12 EDK38342.1 - 7.1 6.6 9.1 3.9 7.5 6.8 1.6 2 0 0 2 2 2 0 Protein trafficking PGA2 PhoLip_ATPase_C PF16212.5 EDK38343.2 - 3.9e-73 246.3 25.4 3.9e-73 246.3 25.4 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDK38343.2 - 9.2e-19 66.9 0.7 2.8e-18 65.3 0.7 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EDK38343.2 - 1.9e-10 40.6 0.0 6e-10 39.1 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDK38343.2 - 5.9e-10 39.8 0.2 0.00038 20.8 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDK38343.2 - 6.2e-07 29.1 0.9 1.2e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDK38343.2 - 0.00092 19.0 0.0 0.00092 19.0 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CPSF100_C PF13299.6 EDK38344.2 - 1.5e-29 103.4 2.8 9.4e-29 100.8 0.0 2.8 2 1 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Lactamase_B_6 PF16661.5 EDK38344.2 - 3.9e-28 98.2 0.0 7.8e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EDK38344.2 - 1.4e-12 47.9 0.0 5.4e-12 46.0 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain SF1-HH PF16275.5 EDK38345.2 - 4.5e-34 117.2 0.2 4.5e-34 117.2 0.2 2.3 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EDK38345.2 - 2.3e-06 27.3 0.1 1.3e-05 25.0 0.1 1.9 1 1 1 2 2 2 1 KH domain zf-CCHC PF00098.23 EDK38345.2 - 5.8e-06 26.1 0.2 9.2e-06 25.5 0.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EDK38345.2 - 0.0037 17.1 2.6 0.0075 16.1 2.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EDK38345.2 - 0.023 14.7 0.0 0.055 13.4 0.0 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EDK38345.2 - 0.15 11.8 0.9 0.27 11.0 0.9 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EDK38345.2 - 0.27 11.0 1.5 0.62 9.8 1.5 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger MTS PF05175.14 EDK38346.2 - 8.7e-06 25.4 0.0 3.4e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EDK38346.2 - 0.021 15.6 0.0 0.52 11.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF938 PF06080.12 EDK38346.2 - 0.077 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) PhageP22-tail PF09251.10 EDK38346.2 - 0.19 10.0 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike ubiquitin PF00240.23 EDK38347.2 - 8.2e-24 83.2 0.0 9.2e-24 83.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDK38347.2 - 1.7e-13 50.2 0.0 1.8e-13 50.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EDK38347.2 - 0.0026 17.7 0.0 0.003 17.5 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain TUG-UBL1 PF11470.8 EDK38347.2 - 0.036 14.3 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 TUG ubiquitin-like domain Ubiquitin_2 PF14560.6 EDK38347.2 - 0.069 13.6 0.0 0.1 13.1 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 EDK38347.2 - 0.069 13.7 0.0 0.089 13.4 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TPR_14 PF13428.6 EDK38348.2 - 1.5e-13 50.3 0.3 0.39 11.7 0.0 7.7 7 1 2 9 9 9 4 Tetratricopeptide repeat HAT PF02184.16 EDK38348.2 - 1.4e-09 37.7 31.9 0.023 14.6 0.3 10.4 10 0 0 10 10 10 4 HAT (Half-A-TPR) repeat Suf PF05843.14 EDK38348.2 - 4.8e-06 26.8 25.1 0.0072 16.4 1.4 6.6 3 2 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EDK38348.2 - 7.1e-05 23.2 0.0 0.34 11.4 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDK38348.2 - 0.00085 19.2 0.4 4.7 7.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38348.2 - 0.018 15.1 3.9 7.8 6.9 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDK38348.2 - 0.037 14.6 4.4 28 5.7 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38348.2 - 0.043 14.1 1.3 53 4.2 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EDK38348.2 - 0.41 10.7 11.9 0.22 11.6 1.5 5.1 5 1 1 6 6 6 0 U3 small nucleolar RNA-associated protein 6 PA PF02225.22 EDK38349.2 - 4.1e-10 39.5 0.0 7.5e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 PA domain Peptidase_M28 PF04389.17 EDK38349.2 - 3.9e-07 29.9 0.0 1.3e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 Rad21_Rec8_N PF04825.13 EDK38350.2 - 2.9e-12 46.7 0.2 6.3e-12 45.6 0.2 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDK38350.2 - 0.078 12.3 0.1 0.36 10.2 0.0 2.1 2 0 0 2 2 2 0 Conserved region of Rad21 / Rec8 like protein Pil1 PF13805.6 EDK38351.1 - 1.1e-123 411.9 0.8 1.5e-123 411.5 0.8 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.10 EDK38351.1 - 0.0078 16.4 3.3 0.36 11.1 0.2 3.4 3 0 0 3 3 3 1 Proto-chlorophyllide reductase 57 kD subunit Nop10p PF04135.12 EDK38351.1 - 1.2 9.2 3.9 4.2 7.5 0.2 2.4 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family Hat1_N PF10394.9 EDK38352.1 - 3e-41 141.3 0.8 6.2e-41 140.3 0.8 1.6 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus CT_A_B PF02626.15 EDK38353.2 - 3.5e-85 285.8 0.0 6.1e-85 285.0 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CT_C_D PF02682.16 EDK38353.2 - 3.1e-47 160.9 0.0 4.8e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_lipoyl PF00364.22 EDK38353.2 - 1.4e-17 63.3 1.5 1.4e-17 63.3 1.5 3.0 4 0 0 4 4 4 1 Biotin-requiring enzyme RnfC_N PF13375.6 EDK38353.2 - 0.0033 17.3 0.3 0.01 15.8 0.3 1.9 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain DUF5101 PF17031.5 EDK38353.2 - 0.094 12.8 0.3 0.17 12.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) Biotin_lipoyl_2 PF13533.6 EDK38353.2 - 0.26 11.1 10.5 2.1 8.2 0.7 3.8 3 1 1 4 4 4 0 Biotin-lipoyl like CPSase_L_D2 PF02786.17 EDK38354.2 - 2.1e-60 203.8 0.0 3.8e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDK38354.2 - 1.2e-40 138.5 0.0 3.4e-40 137.0 0.1 1.8 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDK38354.2 - 1.5e-12 47.5 0.1 7.7e-12 45.3 0.1 2.2 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain Amidase PF01425.21 EDK38354.2 - 3.4e-11 42.8 0.0 5.8e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Amidase Dala_Dala_lig_C PF07478.13 EDK38354.2 - 1.6e-10 40.9 0.0 3.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDK38354.2 - 1.4e-05 24.7 0.0 2.8e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDK38354.2 - 0.0029 17.7 0.0 0.0089 16.1 0.0 1.8 2 1 0 2 2 2 1 ATP-grasp domain ATP-grasp_5 PF13549.6 EDK38354.2 - 0.0042 16.6 0.1 0.0093 15.4 0.1 1.6 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 EDK38354.2 - 0.13 12.0 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Amidase PF01425.21 EDK38355.2 - 1.1e-74 252.0 0.0 1.4e-74 251.7 0.0 1.0 1 0 0 1 1 1 1 Amidase DUF1761 PF08570.10 EDK38356.1 - 0.0023 18.2 1.5 0.0063 16.8 1.5 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1761) YoqO PF14037.6 EDK38356.1 - 0.019 15.5 1.2 0.029 14.9 1.2 1.3 1 0 0 1 1 1 0 YoqO-like protein OST3_OST6 PF04756.13 EDK38356.1 - 0.077 12.3 1.5 0.098 12.0 1.5 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Spore_YhaL PF14147.6 EDK38356.1 - 0.57 9.9 3.1 1.4 8.7 3.1 1.6 1 0 0 1 1 1 0 Sporulation protein YhaL SSF PF00474.17 EDK38357.2 - 2e-16 59.9 31.0 2.7e-16 59.4 31.0 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family ETRAMP PF09716.10 EDK38357.2 - 1.9 8.6 4.3 1.7 8.7 0.2 3.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Vps36_ESCRT-II PF11605.8 EDK38358.2 - 2.4e-29 101.4 0.1 4.6e-29 100.4 0.1 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EAP30 PF04157.16 EDK38358.2 - 8.5e-27 94.0 0.0 1.5e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EDK38358.2 - 3.9e-17 61.4 1.7 3.9e-17 61.4 1.7 2.7 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RanBP PF00641.18 EDK38358.2 - 0.015 14.6 2.2 0.015 14.6 2.2 2.7 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others DZR PF12773.7 EDK38358.2 - 0.024 14.7 7.1 0.031 14.3 5.2 2.1 1 1 1 2 2 2 0 Double zinc ribbon AviRa PF11599.8 EDK38358.2 - 0.028 13.9 0.1 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 RRNA methyltransferase AviRa GRAM PF02893.20 EDK38358.2 - 0.041 13.7 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 GRAM domain Mo25 PF08569.11 EDK38359.2 - 4.8e-119 397.5 5.5 5.4e-119 397.4 5.5 1.0 1 0 0 1 1 1 1 Mo25-like DUF1951 PF09188.10 EDK38359.2 - 0.083 12.9 5.6 1 9.4 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1951) Aminotran_4 PF01063.19 EDK38360.2 - 6.7e-34 117.7 0.0 8.9e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Glyco_hydro_47 PF01532.20 EDK38361.2 - 1.7e-121 406.3 0.0 2.8e-121 405.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 UDPG_MGDP_dh_C PF03720.15 EDK38361.2 - 0.11 12.9 0.1 1.5 9.2 0.0 2.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DUF624 PF04854.14 EDK38361.2 - 0.11 12.6 0.1 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Phosphodiest PF01663.22 EDK38362.2 - 3e-13 50.1 0.5 4.6e-13 49.5 0.5 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDK38362.2 - 3.4e-05 23.4 0.1 5e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EDK38362.2 - 0.00042 19.7 0.1 0.00068 19.1 0.1 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 EDK38362.2 - 0.26 11.4 0.5 7.4 6.6 0.1 2.3 2 0 0 2 2 2 0 PglZ domain Pkinase PF00069.25 EDK38364.2 - 6.5e-69 232.2 0.0 8.6e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38364.2 - 8.5e-31 107.2 0.0 1.3e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDK38364.2 - 9.7e-13 48.6 0.7 4.5e-12 46.5 0.7 2.3 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 EDK38364.2 - 5.9e-10 39.3 0.0 2.4e-06 27.8 0.0 2.7 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 EDK38364.2 - 1.1e-08 34.8 0.0 5.6e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK38364.2 - 0.0013 17.8 0.3 0.003 16.6 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 EDK38364.2 - 0.014 15.1 0.1 0.62 9.6 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDK38364.2 - 0.066 12.5 0.1 0.21 10.9 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK38364.2 - 0.066 13.1 0.2 0.11 12.4 0.2 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Adeno_E3_15_3 PF03307.14 EDK38364.2 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region YrbL-PhoP_reg PF10707.9 EDK38364.2 - 0.17 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ribosomal_L28 PF00830.19 EDK38365.2 - 3e-10 40.1 2.3 5.5e-10 39.3 2.3 1.5 1 0 0 1 1 1 1 Ribosomal L28 family DsbC_N PF10411.9 EDK38365.2 - 0.03 13.8 0.0 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Disulfide bond isomerase protein N-terminus DUF1640 PF07798.11 EDK38367.2 - 8.9e-34 117.0 6.7 1.3e-33 116.5 6.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) SWIRM-assoc_1 PF16495.5 EDK38367.2 - 0.029 14.3 1.0 0.078 12.9 1.0 1.8 1 0 0 1 1 1 0 SWIRM-associated region 1 AAA PF00004.29 EDK38368.2 - 4.1e-95 315.2 0.0 4.4e-47 159.8 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK38368.2 - 5e-22 77.4 0.3 1.4e-09 37.6 0.2 2.9 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDK38368.2 - 2.8e-15 56.4 0.0 2.7e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDK38368.2 - 2.7e-13 50.4 0.1 6.8e-05 23.1 0.0 3.4 3 1 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDK38368.2 - 1.6e-12 48.1 1.4 9.9e-05 22.8 0.1 4.5 3 2 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EDK38368.2 - 2.4e-11 44.0 4.1 0.025 14.8 0.0 6.1 4 2 3 7 7 5 2 AAA domain AAA_5 PF07728.14 EDK38368.2 - 6.4e-10 39.2 0.4 0.00012 22.1 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK38368.2 - 7.1e-10 39.2 0.2 0.0014 18.8 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 EDK38368.2 - 1.1e-08 35.2 0.0 0.0023 18.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EDK38368.2 - 1.8e-08 34.0 0.0 0.00092 18.5 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 EDK38368.2 - 4.1e-08 33.6 0.0 0.002 18.5 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 EDK38368.2 - 4.4e-08 33.7 2.9 0.00029 21.4 0.0 4.3 5 0 0 5 5 3 2 AAA domain ABC_tran PF00005.27 EDK38368.2 - 5.8e-08 33.4 0.0 0.0095 16.4 0.0 3.4 2 1 0 2 2 2 2 ABC transporter Vps4_C PF09336.10 EDK38368.2 - 1.1e-07 31.7 0.1 0.00047 20.1 0.0 2.9 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 EDK38368.2 - 4.8e-07 29.4 0.4 0.023 14.1 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDK38368.2 - 8e-07 29.4 0.0 0.01 16.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 EDK38368.2 - 8.5e-07 28.4 0.0 0.029 13.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 EDK38368.2 - 1e-06 28.6 0.2 0.068 12.9 0.0 3.0 2 1 0 3 3 3 2 IstB-like ATP binding protein Cytidylate_kin2 PF13189.6 EDK38368.2 - 1.2e-06 28.7 0.0 0.00033 20.8 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase-like family Rad17 PF03215.15 EDK38368.2 - 2.3e-06 27.7 0.0 0.019 14.9 0.0 2.9 3 0 0 3 3 2 2 Rad17 P-loop domain AAA_17 PF13207.6 EDK38368.2 - 3.3e-06 27.5 0.0 0.0073 16.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDK38368.2 - 6.3e-06 25.9 0.8 0.24 10.9 0.1 4.2 3 1 1 4 4 4 1 AAA domain ATPase_2 PF01637.18 EDK38368.2 - 1e-05 25.5 0.5 0.33 10.8 0.0 4.1 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_3 PF07726.11 EDK38368.2 - 1.3e-05 25.0 0.0 0.099 12.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDK38368.2 - 2.1e-05 24.3 0.4 0.061 13.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EDK38368.2 - 2.3e-05 23.7 0.0 1.3 8.2 0.0 3.6 3 0 0 3 3 3 2 NB-ARC domain AAA_7 PF12775.7 EDK38368.2 - 3.2e-05 23.5 0.0 0.062 12.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region TsaE PF02367.17 EDK38368.2 - 3.7e-05 23.7 0.0 0.13 12.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EDK38368.2 - 4.2e-05 23.5 0.1 0.19 11.6 0.0 3.0 3 0 0 3 3 3 2 NACHT domain DUF815 PF05673.13 EDK38368.2 - 0.00014 21.2 0.0 0.097 11.8 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase PF06745.13 EDK38368.2 - 0.00014 21.3 0.6 2.6 7.3 0.0 3.8 4 0 0 4 4 4 1 KaiC SKI PF01202.22 EDK38368.2 - 0.0002 21.5 1.7 0.091 12.9 0.0 3.0 3 0 0 3 3 2 1 Shikimate kinase Viral_helicase1 PF01443.18 EDK38368.2 - 0.00021 21.1 0.6 0.69 9.6 0.0 3.4 4 0 0 4 4 3 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 EDK38368.2 - 0.00045 19.9 0.0 0.28 10.9 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EDK38368.2 - 0.00093 18.4 0.2 0.63 9.1 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 FeoB_N PF02421.18 EDK38368.2 - 0.0013 18.3 0.3 1.2 8.7 0.0 3.9 3 1 1 4 4 4 1 Ferrous iron transport protein B AAA_11 PF13086.6 EDK38368.2 - 0.0018 18.1 10.7 1.1 9.0 0.0 3.6 4 0 0 4 4 3 2 AAA domain Sigma54_activ_2 PF14532.6 EDK38368.2 - 0.0028 17.8 0.0 2.9 8.0 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain CPT PF07931.12 EDK38368.2 - 0.0055 16.6 0.0 0.11 12.3 0.0 2.8 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 EDK38368.2 - 0.0065 16.4 0.0 1.4 8.8 0.0 2.7 2 0 0 2 2 2 1 NTPase PhoH PF02562.16 EDK38368.2 - 0.0078 15.7 0.2 1.7 8.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein PduV-EutP PF10662.9 EDK38368.2 - 0.008 15.9 0.0 2.2 8.0 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 EDK38368.2 - 0.0092 16.3 0.2 1.4 9.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 EDK38368.2 - 0.01 15.6 0.1 0.63 9.7 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase TniB PF05621.11 EDK38368.2 - 0.014 14.9 0.0 8.3 5.8 0.0 3.4 4 0 0 4 4 3 0 Bacterial TniB protein SRPRB PF09439.10 EDK38368.2 - 0.023 14.1 0.0 4.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDK38368.2 - 0.026 14.6 0.1 0.7 10.0 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Hydin_ADK PF17213.3 EDK38368.2 - 0.03 14.6 4.1 9.6 6.4 0.0 3.4 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_23 PF13476.6 EDK38368.2 - 0.034 14.7 11.0 0.24 11.9 0.0 3.8 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EDK38368.2 - 0.034 14.0 0.0 0.48 10.3 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AFG1_ATPase PF03969.16 EDK38368.2 - 0.041 12.8 0.1 5.6 5.7 0.0 2.5 2 0 0 2 2 2 0 AFG1-like ATPase AAA_29 PF13555.6 EDK38368.2 - 0.062 13.1 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain ADK PF00406.22 EDK38368.2 - 0.077 13.1 0.0 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Adenylate kinase AAA_30 PF13604.6 EDK38368.2 - 0.092 12.5 0.2 6.4 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain TERF2_RBM PF16772.5 EDK38368.2 - 0.16 11.5 0.0 0.16 11.5 0.0 2.3 3 0 0 3 3 2 0 Telomeric repeat-binding factor 2 Rap1-binding motif HSP9_HSP12 PF04119.12 EDK38369.1 - 6.3e-25 87.3 4.8 6.3e-25 87.3 4.8 2.3 2 1 0 2 2 2 1 Heat shock protein 9/12 SNARE PF05739.19 EDK38369.1 - 0.04 13.9 4.1 0.83 9.7 0.2 2.7 1 1 1 2 2 2 0 SNARE domain Grg1 PF11034.8 EDK38369.1 - 0.054 13.7 18.5 0.36 11.1 0.9 3.2 2 1 1 3 3 3 0 Glucose-repressible protein Grg1 Importin_rep_6 PF18829.1 EDK38369.1 - 0.1 12.7 1.2 0.23 11.6 0.6 1.8 1 1 1 2 2 2 0 Importin repeat 6 DUF883 PF05957.13 EDK38369.1 - 0.15 12.7 6.4 0.26 11.9 3.7 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) MT0933_antitox PF14013.6 EDK38369.1 - 0.31 11.4 15.7 2.1 8.7 5.6 3.5 2 2 2 4 4 4 0 MT0933-like antitoxin protein DUF4449 PF14613.6 EDK38369.1 - 0.36 10.9 7.1 0.59 10.2 7.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) YtxH PF12732.7 EDK38369.1 - 1.3 9.6 15.2 3.4e+02 1.9 15.2 2.8 1 1 0 1 1 1 0 YtxH-like protein RRM_1 PF00076.22 EDK38370.2 - 3.7e-08 33.1 1.2 1.2e-05 25.0 0.1 3.3 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Herpes_MCP PF03122.14 EDK38370.2 - 0.01 13.3 1.8 0.013 13.0 1.8 1.1 1 0 0 1 1 1 0 Herpes virus major capsid protein Dopey_N PF04118.14 EDK38372.2 - 2.2e-112 375.1 3.3 3.3e-111 371.3 1.7 2.8 2 0 0 2 2 2 2 Dopey, N-terminal Abhydrolase_2 PF02230.16 EDK38373.1 - 7.9e-49 166.4 0.0 9.2e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EDK38373.1 - 2.2e-08 33.7 0.0 0.0003 20.1 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EDK38373.1 - 2.8e-07 30.4 0.1 4.5e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 EDK38373.1 - 1.1e-06 28.4 0.1 1.4e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EDK38373.1 - 0.0098 15.4 0.1 0.27 10.7 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EDK38373.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 EDK38373.1 - 0.034 14.7 0.0 0.037 14.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family BAAT_C PF08840.11 EDK38373.1 - 0.055 13.4 0.1 0.094 12.6 0.1 1.3 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EDK38373.1 - 0.086 12.7 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIP PF03583.14 EDK38373.1 - 0.091 12.1 0.1 0.49 9.7 0.0 2.0 2 1 1 3 3 3 0 Secretory lipase Cutinase PF01083.22 EDK38373.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Cutinase Dus PF01207.17 EDK38374.1 - 3.5e-78 262.8 0.0 4.8e-78 262.4 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-C2H2 PF00096.26 EDK38375.2 - 5.4e-07 29.7 11.2 0.0031 17.9 3.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK38375.2 - 3.1e-06 27.4 3.9 3.1e-06 27.4 3.9 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK38375.2 - 0.00059 20.5 11.1 0.045 14.6 2.7 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger Cauli_AT PF03233.13 EDK38375.2 - 0.37 10.7 4.2 0.38 10.6 0.1 2.6 3 0 0 3 3 3 0 Aphid transmission protein zf-C2H2_3rep PF18868.1 EDK38375.2 - 0.74 10.5 4.2 8 7.2 1.2 3.3 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EDK38375.2 - 1.3 8.9 7.3 0.12 12.1 0.6 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Glyco_tran_28_C PF04101.16 EDK38376.2 - 1.7e-18 67.1 0.3 8.4e-18 64.9 0.3 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain THF_DHG_CYH_C PF02882.19 EDK38376.2 - 0.0096 15.3 0.9 0.049 13.0 0.1 2.3 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TFIID-18kDa PF02269.16 EDK38377.2 - 2.4e-18 65.9 0.0 3.8e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit DUF1931 PF09123.11 EDK38377.2 - 0.0048 17.0 0.0 0.0093 16.1 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1931) RINGv PF12906.7 EDK38378.2 - 3.9e-16 58.9 10.1 8.8e-16 57.8 10.1 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EDK38378.2 - 0.0066 16.8 9.0 0.013 15.8 9.0 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EDK38378.2 - 0.46 10.7 5.0 1.3 9.2 5.0 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EDK38378.2 - 9.3 6.2 6.6 19 5.2 6.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pribosyl_synth PF14572.6 EDK38379.2 - 2.6e-42 144.9 3.0 8e-36 123.8 1.6 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDK38379.2 - 9.8e-39 131.9 0.4 3.6e-38 130.1 0.0 2.1 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDK38379.2 - 2.7e-17 62.7 1.3 1.6e-16 60.3 0.9 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDK38379.2 - 0.034 13.6 0.1 0.065 12.7 0.1 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase TAFII55_N PF04658.13 EDK38380.2 - 4.8e-39 133.7 0.0 4.8e-39 133.7 0.0 2.6 3 1 0 3 3 3 1 TAFII55 protein conserved region PDDEXK_6 PF04720.12 EDK38380.2 - 1.9 8.3 10.3 3.6 7.5 10.3 1.5 1 0 0 1 1 1 0 PDDEXK-like family of unknown function P5-ATPase PF12409.8 EDK38381.2 - 1.1e-35 122.4 0.0 3.2e-35 120.9 0.0 1.9 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EDK38381.2 - 5.1e-32 110.9 0.3 1.6e-31 109.2 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDK38381.2 - 3.8e-16 60.0 0.0 1.8e-10 41.5 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EDK38381.2 - 4.4e-07 29.8 5.6 4.4e-07 29.8 5.6 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EDK38381.2 - 7.5e-05 22.3 0.0 0.00021 20.9 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDK38381.2 - 0.00011 22.2 0.0 0.00026 21.0 0.0 1.7 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDK38381.2 - 0.032 14.0 0.3 3.7 7.2 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Gpr1_Fun34_YaaH PF01184.19 EDK38382.1 - 6.5e-91 303.5 24.1 7.5e-91 303.3 24.1 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF202 PF02656.15 EDK38383.1 - 1.9e-15 57.0 4.5 1.9e-15 57.0 4.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 EDK38383.1 - 0.66 9.8 4.3 3.6 7.5 4.3 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5337) DUF2347 PF09804.9 EDK38384.2 - 2.2e-76 257.1 2.9 2.2e-76 257.1 2.9 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EDK38384.2 - 2.4e-15 57.2 10.5 1.6e-05 25.1 0.1 3.4 1 1 2 3 3 3 3 Domain of unknown function (DUF4484) Avl9 PF09794.9 EDK38384.2 - 5.1e-09 35.3 0.2 1.1e-08 34.3 0.2 1.6 1 1 0 1 1 1 1 Transport protein Avl9 Aldo_ket_red PF00248.21 EDK38385.2 - 2.2e-59 201.1 0.0 2.9e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Homeodomain PF00046.29 EDK38386.2 - 2.5e-18 65.7 1.1 4.4e-18 64.9 1.1 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDK38386.2 - 0.00037 20.3 0.8 0.00076 19.3 0.8 1.5 1 0 0 1 1 1 1 Homeobox KN domain B2-adapt-app_C PF09066.10 EDK38386.2 - 0.12 12.4 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain Homez PF11569.8 EDK38386.2 - 0.13 11.7 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Sel1 PF08238.12 EDK38387.2 - 0.00027 21.5 0.3 0.65 10.8 0.0 4.0 4 0 0 4 4 4 2 Sel1 repeat AATF-Che1 PF13339.6 EDK38387.2 - 0.27 11.9 3.4 1.1 9.9 1.3 2.5 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Pkinase PF00069.25 EDK38388.2 - 1.7e-54 185.0 0.0 2e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38388.2 - 1.7e-24 86.5 0.0 2e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK38388.2 - 6.6e-06 25.1 0.0 1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDK38388.2 - 0.0057 16.0 0.0 0.0085 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDK38388.2 - 0.024 13.9 0.1 2.7 7.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RINT1_TIP1 PF04437.13 EDK38389.2 - 8.3e-120 401.0 19.6 8.3e-120 401.0 19.6 1.8 2 0 0 2 2 2 1 RINT-1 / TIP-1 family RNase_J_C PF17770.1 EDK38389.2 - 0.44 11.6 2.0 4.3 8.4 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain Cpn60_TCP1 PF00118.24 EDK38390.2 - 1.7e-167 558.0 3.3 2e-167 557.8 3.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NusA_N PF08529.11 EDK38390.2 - 0.11 12.8 1.1 0.48 10.8 1.1 2.1 1 0 0 1 1 1 0 NusA N-terminal domain SH3_1 PF00018.28 EDK38391.2 - 7.8e-08 31.8 0.4 1.7e-07 30.7 0.4 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EDK38391.2 - 6.6e-05 22.5 0.2 0.00015 21.3 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDK38391.2 - 8.6e-05 22.3 0.5 0.00018 21.3 0.5 1.6 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.25 EDK38392.2 - 2.4e-69 233.7 0.0 2.8e-69 233.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38392.2 - 6.9e-31 107.5 0.0 8.7e-31 107.1 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK38392.2 - 0.00054 19.4 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDK38392.2 - 0.0029 17.6 0.1 0.0047 16.9 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDK38392.2 - 0.17 10.6 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DAO PF01266.24 EDK38393.2 - 4.6e-55 187.6 0.0 5.6e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDK38393.2 - 0.0018 18.5 0.2 0.0081 16.4 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK38393.2 - 0.0096 15.2 0.2 2.8 7.1 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK38393.2 - 0.089 12.0 0.9 0.16 11.2 0.9 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4780 PF16012.5 EDK38393.2 - 0.17 11.3 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) Mqo PF06039.15 EDK38393.2 - 0.19 10.3 0.0 0.67 8.4 0.0 1.9 3 0 0 3 3 3 0 Malate:quinone oxidoreductase (Mqo) VTC PF09359.10 EDK38394.1 - 1.1e-101 339.9 0.1 1.1e-101 339.9 0.1 1.7 2 0 0 2 2 2 1 VTC domain DUF202 PF02656.15 EDK38394.1 - 5.9e-13 49.1 6.1 5.9e-13 49.1 6.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EDK38394.1 - 1.1e-08 35.5 19.8 6.1e-06 26.4 0.5 4.1 4 1 1 5 5 5 3 SPX domain LXG PF04740.12 EDK38394.1 - 0.02 14.6 4.0 5 6.8 4.0 2.6 1 1 0 1 1 1 0 LXG domain of WXG superfamily Rrn6 PF10214.9 EDK38394.1 - 0.079 11.4 0.7 0.15 10.6 0.7 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MazG PF03819.17 EDK38394.1 - 0.085 13.0 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain DAO PF01266.24 EDK38395.2 - 7.9e-29 101.3 0.0 9e-29 101.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EDK38395.2 - 0.016 14.1 0.0 0.85 8.4 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.17 EDK38395.2 - 0.025 13.8 0.1 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.14 EDK38395.2 - 0.041 13.1 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK38395.2 - 0.042 14.4 0.2 0.11 13.1 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK38395.2 - 0.095 12.9 0.3 0.24 11.6 0.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain PhoLip_ATPase_C PF16212.5 EDK38396.2 - 1.8e-66 224.4 23.1 1.8e-66 224.4 23.1 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDK38396.2 - 2.9e-22 78.1 1.7 2.9e-22 78.1 1.7 3.3 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EDK38396.2 - 3.3e-13 50.4 1.4 1.7e-06 28.5 0.1 3.5 2 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDK38396.2 - 7.3e-12 45.2 0.0 3.5e-11 43.0 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EDK38396.2 - 3.1e-11 43.1 1.3 4.3e-11 42.7 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDK38396.2 - 0.0045 16.7 0.1 0.0045 16.7 0.1 3.4 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDK38396.2 - 0.044 13.9 0.5 0.2 11.7 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Pyr_redox_2 PF07992.14 EDK38397.2 - 1.1e-23 83.9 0.0 1.6e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK38397.2 - 2.5e-07 31.2 0.6 5.5e-05 23.7 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK38397.2 - 2.6e-05 23.5 0.8 0.00072 18.8 0.1 2.1 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDK38397.2 - 0.001 19.1 0.8 0.046 13.7 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EDK38397.2 - 0.0066 15.7 0.7 0.012 14.9 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.23 EDK38397.2 - 0.075 13.1 0.0 14 5.7 0.0 2.5 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Aft1_HRA PF11786.8 EDK38398.2 - 0.029 14.7 0.6 0.88 9.9 0.2 2.9 2 0 0 2 2 2 0 Aft1 HRA domain DUF3336 PF11815.8 EDK38399.2 - 4.3e-33 113.9 3.1 7.4e-33 113.2 3.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDK38399.2 - 2.3e-06 27.9 0.2 6.1e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Erf4 PF10256.9 EDK38399.2 - 0.0029 17.7 1.0 0.028 14.5 0.1 2.8 3 0 0 3 3 3 1 Golgin subfamily A member 7/ERF4 family ELP6 PF09807.9 EDK38400.2 - 7.5e-07 28.8 0.0 8.6e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 Elongation complex protein 6 rpo132 PF12415.8 EDK38400.2 - 0.081 12.2 0.1 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase Mito_carr PF00153.27 EDK38401.2 - 1.9e-62 207.2 2.0 1.3e-24 86.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDK38401.2 - 0.00088 18.5 1.0 0.15 11.2 0.2 2.5 2 1 1 3 3 3 2 Gammaproteobacterial serine protease Peptidase_M22 PF00814.25 EDK38402.2 - 7.7e-56 189.8 0.0 1.1e-55 189.2 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.20 EDK38402.2 - 0.011 15.2 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Nse4_C PF08743.10 EDK38403.2 - 4.3e-25 87.8 0.1 1.2e-24 86.4 0.1 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EDK38403.2 - 1.4e-05 25.1 0.1 3.6e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Mlh1_C PF16413.5 EDK38404.2 - 1.9e-75 253.7 0.3 2.9e-75 253.1 0.3 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EDK38404.2 - 2.2e-33 114.4 0.1 4.2e-33 113.5 0.1 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDK38404.2 - 2.1e-14 53.5 0.1 4.9e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDK38404.2 - 3.9e-06 27.3 0.1 1.1e-05 25.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_14 PF13428.6 EDK38405.2 - 4.7e-08 33.2 1.7 0.0012 19.5 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDK38405.2 - 1.3e-07 32.0 0.2 1.4 9.5 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDK38405.2 - 0.0022 18.2 2.0 0.97 10.0 0.2 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDK38405.2 - 0.066 13.3 0.0 1.9 8.7 0.0 3.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 EDK38405.2 - 0.9 9.8 9.9 6.8 7.1 0.1 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDK38405.2 - 7.5 6.6 10.5 2.1 8.3 0.3 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat SUI1 PF01253.22 EDK38406.1 - 1.7e-21 76.5 0.7 1.7e-21 76.5 0.7 2.3 2 0 0 2 2 2 1 Translation initiation factor SUI1 MoCF_biosynth PF00994.24 EDK38406.1 - 0.23 11.1 2.5 0.43 10.2 0.5 2.1 1 1 1 2 2 2 0 Probable molybdopterin binding domain Coq4 PF05019.13 EDK38407.2 - 0.019 14.3 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Zn_clus PF00172.18 EDK38408.2 - 2.2e-08 34.1 6.4 3.5e-08 33.5 6.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_16 PF13191.6 EDK38409.2 - 1.2e-06 29.0 0.4 5.7e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK38409.2 - 0.0016 18.7 0.0 0.0043 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EDK38409.2 - 0.024 15.1 0.0 0.069 13.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK38409.2 - 0.056 13.4 0.0 1 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2151 PF10221.9 EDK38409.2 - 0.098 11.2 0.1 0.098 11.2 0.1 2.2 1 1 1 2 2 2 0 Cell cycle and development regulator Sensor PF13796.6 EDK38409.2 - 0.29 11.2 0.0 0.49 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative sensor LAP1C PF05609.12 EDK38409.2 - 2.1 7.4 17.8 3.3 6.7 17.8 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) HECT PF00632.25 EDK38410.2 - 2.2e-86 290.1 1.8 4.9e-86 289.0 1.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Fungal_trans PF04082.18 EDK38411.2 - 1.9e-13 50.1 0.6 3.6e-13 49.2 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK38411.2 - 1.2e-08 34.9 10.1 2e-08 34.2 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase_6 PF13344.6 EDK38412.2 - 4.3e-25 87.8 0.0 7.7e-25 86.9 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK38412.2 - 1.2e-10 42.0 0.0 1.6e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDK38412.2 - 7.8e-09 35.5 0.0 1.7e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 EDK38412.2 - 1.4e-05 25.3 0.3 0.019 15.0 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Tsp45I PF06300.12 EDK38413.2 - 0.089 12.3 0.1 0.12 11.9 0.1 1.1 1 0 0 1 1 1 0 Tsp45I type II restriction enzyme DUF4218 PF13960.6 EDK38413.2 - 0.12 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Rpp20 PF12328.8 EDK38414.2 - 2.4e-31 108.5 0.7 3.4e-31 108.0 0.7 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EDK38414.2 - 1.1e-11 44.4 0.5 2e-11 43.5 0.5 1.5 1 0 0 1 1 1 1 Alba Pam16 PF03656.13 EDK38415.2 - 1.3e-07 31.7 0.0 2.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EDK38415.2 - 0.00011 22.2 0.1 0.00019 21.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L24e PF01246.20 EDK38416.1 - 7.7e-31 106.1 2.9 2.3e-30 104.6 2.9 1.9 1 0 0 1 1 1 1 Ribosomal protein L24e Trypan_PARP PF05887.11 EDK38416.1 - 0.0097 15.9 1.5 0.013 15.4 1.5 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) DUF4636 PF15468.6 EDK38416.1 - 0.13 12.0 4.8 0.16 11.6 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) AAA_23 PF13476.6 EDK38416.1 - 0.21 12.1 2.9 0.26 11.8 2.9 1.2 1 0 0 1 1 1 0 AAA domain ANTH PF07651.16 EDK38417.2 - 1.3e-62 211.3 3.9 1.3e-62 211.3 3.9 2.1 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 EDK38417.2 - 5.4e-08 32.9 1.7 1.3e-07 31.7 0.5 2.3 2 0 0 2 2 2 1 ENTH domain Glyco_hydro_16 PF00722.21 EDK38418.2 - 4.6e-49 166.3 2.4 4.6e-49 166.3 2.4 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Plasmodium_Vir PF05795.11 EDK38418.2 - 5.4 6.3 6.7 8.9 5.6 6.7 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Rhodanese PF00581.20 EDK38419.1 - 8.2e-15 55.3 0.0 1e-14 54.9 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 EDK38419.1 - 0.073 12.9 0.0 0.093 12.5 0.0 1.4 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain CTP_transf_like PF01467.26 EDK38420.2 - 7.9e-33 113.7 0.0 1.3e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like IATP PF04568.12 EDK38420.2 - 0.016 15.6 0.6 0.048 14.1 0.6 1.8 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP DUF3360 PF11840.8 EDK38420.2 - 0.39 9.4 0.4 0.59 8.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) MMM1 PF10296.9 EDK38421.2 - 2.2e-142 474.0 0.1 2.9e-142 473.6 0.1 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Flocculin_t3 PF13928.6 EDK38422.1 - 1.3e-12 48.0 21.0 1.3e-12 48.0 21.0 5.3 4 2 0 4 4 4 1 Flocculin type 3 repeat Flo11 PF10182.9 EDK38422.1 - 4e-08 33.5 0.0 6.7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Flo11 domain Adaptin_N PF01602.20 EDK38424.2 - 2.2e-84 283.9 11.9 2.7e-84 283.6 11.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDK38424.2 - 3.3e-12 46.7 0.1 3.3e-12 46.7 0.1 3.2 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDK38424.2 - 2e-10 40.9 0.9 0.00032 21.0 0.1 4.6 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EDK38424.2 - 7e-09 35.2 0.3 0.2 12.0 0.1 4.9 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EDK38424.2 - 0.00017 22.0 0.1 5.9 7.5 0.1 4.8 5 0 0 5 5 5 1 HEAT-like repeat UPF0054 PF02130.17 EDK38424.2 - 0.051 13.4 0.2 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein family UPF0054 Cyclin_N PF00134.23 EDK38424.2 - 0.088 12.6 0.1 0.52 10.1 0.0 2.2 2 0 0 2 2 2 0 Cyclin, N-terminal domain TilS PF09179.11 EDK38424.2 - 0.097 13.2 0.9 0.53 10.8 0.4 2.3 2 0 0 2 2 2 0 TilS substrate binding domain Arm PF00514.23 EDK38424.2 - 0.27 11.3 5.7 5.5 7.2 0.1 4.2 4 1 1 5 5 5 0 Armadillo/beta-catenin-like repeat DUF913 PF06025.12 EDK38424.2 - 0.59 9.0 6.3 2.6 6.9 2.6 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) XPG_N PF00752.17 EDK38425.2 - 1.1e-34 119.0 0.0 3e-34 117.5 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDK38425.2 - 7.6e-28 96.7 0.0 3.2e-27 94.7 0.0 2.2 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EDK38425.2 - 0.0028 18.2 0.6 0.0097 16.5 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 EDK38425.2 - 0.014 15.7 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family PDGLE PF13190.6 EDK38425.2 - 0.066 13.1 0.3 0.17 11.8 0.3 1.6 1 0 0 1 1 1 0 PDGLE domain RNaseH_C PF09293.10 EDK38425.2 - 0.068 13.5 2.7 8 6.8 0.1 2.8 2 0 0 2 2 2 0 T4 RNase H, C terminal Filaggrin PF03516.13 EDK38425.2 - 0.23 12.2 0.1 0.23 12.2 0.1 2.4 2 0 0 2 2 2 0 Filaggrin DUF2508 PF10704.9 EDK38425.2 - 5.6 7.2 7.7 0.65 10.2 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Y_phosphatase2 PF03162.13 EDK38426.1 - 3.1e-43 147.2 0.3 5.7e-40 136.6 0.3 2.1 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDK38426.1 - 2.1e-06 27.9 0.0 4e-06 27.0 0.0 1.4 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDK38426.1 - 0.052 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase HAGH_C PF16123.5 EDK38427.2 - 1.9e-20 73.1 0.1 3.6e-20 72.3 0.1 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EDK38427.2 - 2.3e-14 53.9 0.2 6.4e-14 52.4 0.2 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDK38427.2 - 0.0001 21.9 0.5 0.0019 17.7 0.5 2.5 1 1 1 2 2 2 1 Beta-lactamase superfamily domain SGS PF05002.15 EDK38428.2 - 6e-27 93.6 4.3 6e-27 93.6 4.3 2.3 2 1 0 2 2 2 1 SGS domain CS PF04969.16 EDK38428.2 - 2.2e-16 60.6 0.1 5.5e-16 59.4 0.1 1.7 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 EDK38428.2 - 7e-10 38.3 0.9 0.00077 19.4 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38428.2 - 7.3e-10 39.0 0.1 1.3e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDK38428.2 - 1.1e-08 34.6 1.2 8.2e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDK38428.2 - 6e-08 32.3 1.3 0.0006 19.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDK38428.2 - 1.9e-05 24.4 0.8 0.045 13.6 0.5 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK38428.2 - 0.00056 20.5 0.1 0.007 17.0 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDK38428.2 - 0.0014 19.1 0.6 2.9 8.7 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDK38428.2 - 0.0019 18.3 0.0 0.023 14.8 0.3 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK38428.2 - 0.0038 17.4 0.1 0.026 14.8 0.1 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3808 PF10300.9 EDK38428.2 - 0.0064 15.3 0.1 0.0093 14.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_3 PF07720.12 EDK38428.2 - 0.0065 16.4 0.9 1.6 8.8 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat SNAP PF14938.6 EDK38428.2 - 0.012 15.0 0.1 0.022 14.2 0.1 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 EDK38428.2 - 0.016 16.0 0.0 0.72 10.8 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDK38428.2 - 0.19 11.8 0.1 0.58 10.3 0.1 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDK38428.2 - 0.32 10.7 3.0 13 5.6 0.1 2.6 2 1 1 3 3 3 0 TPR repeat SHNi-TPR PF10516.9 EDK38428.2 - 9.9 5.7 5.8 4.7 6.7 0.2 2.8 3 0 0 3 3 3 0 SHNi-TPR Kinesin PF00225.23 EDK38429.2 - 8.6e-106 353.6 2.1 8.6e-106 353.6 2.1 2.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EDK38429.2 - 4.5e-55 185.7 2.8 4.8e-55 185.6 0.0 2.4 2 1 0 2 2 2 1 Microtubule binding HrpB7 PF09486.10 EDK38429.2 - 0.00047 20.6 7.0 0.00047 20.6 7.0 2.9 1 1 1 2 2 2 1 Bacterial type III secretion protein (HrpB7) TMF_TATA_bd PF12325.8 EDK38429.2 - 0.00094 19.4 38.4 0.0014 18.9 8.5 4.0 1 1 1 3 3 3 2 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 EDK38429.2 - 0.0019 18.3 12.0 0.0019 18.3 12.0 4.4 3 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding HD_4 PF13328.6 EDK38429.2 - 0.3 10.8 3.4 0.28 10.9 1.2 2.1 1 1 1 2 2 2 0 HD domain Spc7 PF08317.11 EDK38429.2 - 1.3 7.9 44.7 0.33 9.8 6.9 3.4 1 1 3 4 4 4 0 Spc7 kinetochore protein Spidroin_N PF16763.5 EDK38429.2 - 9.8 6.2 9.1 9.8 6.2 1.4 3.7 2 2 2 4 4 4 0 Major ampullate spidroin 1, spider silk protein 1, N-term Rrp15p PF07890.12 EDK38430.1 - 1e-30 106.8 10.9 1e-30 106.8 10.9 2.5 2 1 0 2 2 2 1 Rrp15p AF-4 PF05110.13 EDK38430.1 - 0.0072 14.5 21.0 0.011 13.9 21.0 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein SDA1 PF05285.12 EDK38430.1 - 0.05 13.0 26.3 0.062 12.7 26.3 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EDK38430.1 - 0.067 11.5 19.2 0.081 11.2 19.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1639 PF07797.14 EDK38430.1 - 0.52 10.3 4.0 0.63 10.1 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1639) NESP55 PF06390.12 EDK38430.1 - 2.4 7.7 18.6 2.8 7.5 17.4 1.6 1 1 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 EDK38430.1 - 4.9 7.1 13.0 8.6 6.3 13.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PPR PF01535.20 EDK38431.2 - 4.9e-07 29.6 0.2 0.042 14.1 0.0 4.2 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 EDK38431.2 - 5.9e-06 26.4 0.1 1.1 9.5 0.0 4.6 4 0 0 4 4 4 2 PPR repeat family PPR_1 PF12854.7 EDK38431.2 - 0.076 12.7 0.3 0.076 12.7 0.3 2.2 2 0 0 2 2 2 0 PPR repeat AbiJ_NTD4 PF18863.1 EDK38431.2 - 0.15 12.5 7.1 3.8 8.0 0.3 3.9 3 1 1 4 4 4 0 AbiJ N-terminal domain 4 GED PF02212.18 EDK38431.2 - 1.1 9.4 4.7 0.45 10.7 0.3 2.8 3 0 0 3 3 3 0 Dynamin GTPase effector domain Acyltransferase PF01553.21 EDK38432.2 - 1.6e-11 44.0 0.0 2.9e-11 43.1 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Pescadillo_N PF06732.11 EDK38433.2 - 3.6e-124 413.7 1.3 3.6e-124 413.7 1.3 1.8 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EDK38433.2 - 2.8e-09 37.2 0.0 6.7e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Mem_trans PF03547.18 EDK38433.2 - 8.2 4.7 7.7 14 3.9 7.7 1.3 1 0 0 1 1 1 0 Membrane transport protein Med18 PF09637.10 EDK38435.2 - 5.2e-105 350.8 2.6 5.9e-105 350.6 2.6 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.10 EDK38436.1 - 3.4e-09 36.7 18.0 4.6e-08 33.0 18.0 2.0 1 1 0 1 1 1 1 VMA21-like domain ATP-synt_S1 PF05827.12 EDK38437.2 - 1.3e-06 28.3 0.0 3.6e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) ERG4_ERG24 PF01222.17 EDK38438.2 - 8.7e-153 509.1 12.2 9.8e-153 508.9 12.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EDK38438.2 - 3.9e-06 26.5 1.5 3.9e-06 26.5 1.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) TatC PF00902.18 EDK38438.2 - 0.11 12.3 8.1 0.39 10.5 1.1 2.9 3 0 0 3 3 3 0 Sec-independent protein translocase protein (TatC) Sporozoite_P67 PF05642.11 EDK38440.2 - 0.014 13.5 0.8 0.017 13.2 0.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_L3 PF00297.22 EDK38441.1 - 8.2e-188 623.9 11.9 9.3e-188 623.7 11.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Ldh_1_C PF02866.18 EDK38442.1 - 1.2e-46 158.7 0.1 1.9e-46 158.1 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDK38442.1 - 1.2e-42 145.3 0.1 1.9e-42 144.7 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.16 EDK38442.1 - 0.011 15.3 0.1 0.23 11.0 0.1 2.4 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase DBD_HTH PF18430.1 EDK38442.1 - 0.11 12.3 4.1 18 5.2 0.0 3.9 4 0 0 4 4 4 0 Putative DNA-binding domain CRM1_C PF08767.11 EDK38443.2 - 1.6e-122 408.7 4.1 1.6e-122 408.7 4.1 3.0 2 1 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.12 EDK38443.2 - 8.3e-39 133.0 4.5 8.3e-39 133.0 4.5 4.6 6 0 0 6 6 6 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EDK38443.2 - 8.6e-33 111.8 2.4 2.3e-32 110.4 2.4 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EDK38443.2 - 1.9e-28 98.3 3.6 5.5e-28 96.8 1.9 2.9 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 IBN_N PF03810.19 EDK38443.2 - 2.1e-17 62.8 3.1 8.5e-17 60.8 0.9 3.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 EDK38443.2 - 1.6e-15 56.3 1.5 1.6e-15 56.3 1.5 2.7 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat DUF1981 PF09324.10 EDK38443.2 - 0.0039 17.0 0.2 5.4 6.9 0.0 4.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) V-ATPase_H_C PF11698.8 EDK38443.2 - 0.011 15.8 5.7 3.6 7.7 0.3 4.4 3 0 0 3 3 3 0 V-ATPase subunit H Symplekin_C PF12295.8 EDK38443.2 - 0.042 13.9 5.8 1.5 8.9 0.0 4.6 4 0 0 4 4 3 0 Symplekin tight junction protein C terminal DUF4810 PF16068.5 EDK38443.2 - 0.15 12.6 0.0 0.89 10.1 0.0 2.4 3 0 0 3 3 1 0 Domain of unknown function (DUF4810) bPH_4 PF06713.11 EDK38443.2 - 0.16 12.1 2.3 6.6 6.9 0.0 3.4 3 0 0 3 3 3 0 Bacterial PH domain Fanconi_A_N PF15865.5 EDK38443.2 - 0.78 9.1 13.5 1.1 8.6 0.0 4.8 5 1 1 6 6 6 0 Fanconi anaemia group A protein N terminus CTK3 PF12243.8 EDK38443.2 - 0.9 9.5 4.1 7.7 6.5 0.1 4.3 4 1 0 4 4 4 0 CTD kinase subunit gamma CTK3 Ran_BP1 PF00638.18 EDK38444.1 - 1.5e-53 180.3 2.2 2.1e-53 179.8 2.2 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EDK38444.1 - 2e-05 24.5 0.3 0.00025 20.9 0.3 2.2 1 1 0 1 1 1 1 WH1 domain Lig_C PF18330.1 EDK38444.1 - 0.016 15.2 0.3 0.072 13.1 0.0 2.1 2 1 0 2 2 2 0 Ligase Pab1020 C-terminal region Cellulose_synt PF03552.14 EDK38444.1 - 0.042 12.3 0.7 0.056 11.9 0.7 1.1 1 0 0 1 1 1 0 Cellulose synthase DNA_pol_phi PF04931.13 EDK38444.1 - 1.3 7.0 9.9 1.8 6.5 9.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Ank_2 PF12796.7 EDK38445.2 - 6e-26 90.9 1.1 9.9e-09 35.7 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK38445.2 - 4.5e-23 81.3 3.9 6.7e-08 32.9 0.0 5.8 4 2 2 6 6 6 5 Ankyrin repeats (many copies) SPX PF03105.19 EDK38445.2 - 1.7e-17 64.5 20.9 7.7e-08 32.6 3.1 3.9 2 1 2 4 4 4 3 SPX domain Ank_3 PF13606.6 EDK38445.2 - 3.6e-16 57.6 7.4 0.01 16.3 0.0 7.8 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EDK38445.2 - 2.1e-13 50.2 5.8 0.23 11.8 0.1 5.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EDK38445.2 - 1.1e-12 47.8 2.8 0.011 16.1 0.1 6.6 6 0 0 6 6 6 2 Ankyrin repeat GDPD PF03009.17 EDK38445.2 - 2.2e-06 27.6 0.0 5.4e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2013 PF09431.10 EDK38446.2 - 5.7e-40 136.7 11.8 5.7e-40 136.7 11.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) NSP2_assoc PF14758.6 EDK38446.2 - 0.1 13.0 0.9 0.17 12.2 0.9 1.3 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein Ribosomal_L4 PF00573.22 EDK38447.1 - 4.1e-42 144.1 2.4 6.5e-42 143.4 2.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EDK38447.1 - 5.5e-30 103.3 5.9 7.7e-30 102.8 3.5 2.2 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ras PF00071.22 EDK38448.1 - 6.9e-54 181.8 0.1 8.8e-54 181.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK38448.1 - 7.3e-37 126.2 0.0 1e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK38448.1 - 8.3e-17 61.2 0.0 9.9e-17 60.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK38448.1 - 4.9e-08 32.6 0.0 6.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK38448.1 - 3.2e-06 27.2 0.0 4.7e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK38448.1 - 2e-05 24.6 0.2 0.15 12.0 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDK38448.1 - 0.00031 20.3 0.0 0.00043 19.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EDK38448.1 - 0.031 13.7 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 EDK38448.1 - 0.047 14.1 0.0 0.07 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EDK38448.1 - 0.17 11.0 0.0 0.42 9.7 0.0 1.8 1 1 0 1 1 1 0 G-protein alpha subunit Cpn10 PF00166.21 EDK38449.1 - 1.2e-28 99.0 0.0 1.4e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit BP28CT PF08146.12 EDK38450.2 - 7.5e-40 136.3 2.0 7.5e-40 136.3 2.0 3.6 4 0 0 4 4 4 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EDK38450.2 - 1.1e-12 48.3 0.1 1.1e-12 48.3 0.1 5.0 6 0 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 Tti2 PF10521.9 EDK38450.2 - 0.00017 21.3 1.6 3.1 7.2 0.1 5.5 5 2 1 6 6 6 2 Tti2 family HEAT_EZ PF13513.6 EDK38450.2 - 0.017 15.7 0.1 31 5.2 0.0 4.7 4 0 0 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 EDK38450.2 - 0.07 13.5 0.1 5.4 7.5 0.0 3.6 3 0 0 3 3 3 0 HEAT repeats AA_permease PF00324.21 EDK38451.2 - 1.5e-124 416.2 49.6 1.9e-124 415.9 49.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK38451.2 - 5.7e-26 91.3 51.8 7.1e-26 91.0 51.8 1.1 1 0 0 1 1 1 1 Amino acid permease CAP PF00188.26 EDK38452.2 - 8.3e-20 71.9 6.0 1.5e-19 71.1 6.0 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF3808 PF10300.9 EDK38453.2 - 9.9e-119 397.2 0.1 1.3e-118 396.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) OEP PF02321.18 EDK38453.2 - 0.041 13.7 0.4 0.12 12.1 0.4 1.8 1 0 0 1 1 1 0 Outer membrane efflux protein Dsl1_N PF11988.8 EDK38453.2 - 0.061 12.3 1.8 0.11 11.5 1.8 1.3 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal TPR_19 PF14559.6 EDK38453.2 - 0.099 13.2 4.1 0.4 11.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDK38453.2 - 0.11 13.1 2.3 5.6 7.9 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38453.2 - 0.82 9.9 3.9 11 6.4 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK38453.2 - 2.5 8.8 3.7 71 4.2 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat UNC-50 PF05216.13 EDK38454.2 - 4.5e-88 294.5 15.8 5.2e-88 294.3 15.8 1.0 1 0 0 1 1 1 1 UNC-50 family DUF1882 PF08966.11 EDK38454.2 - 0.13 12.6 0.2 0.27 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) Acetyltransf_11 PF13720.6 EDK38454.2 - 0.18 12.3 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 IBR PF01485.21 EDK38456.2 - 9.6e-17 61.0 51.9 6.7e-09 35.8 8.9 5.3 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EDK38456.2 - 0.012 15.5 10.2 0.012 15.5 10.2 5.5 3 3 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Nop14 PF04147.12 EDK38457.2 - 3.8 5.6 19.2 6.8 4.8 19.2 1.3 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EDK38457.2 - 4.5 5.7 10.6 7.1 5.0 10.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pam16 PF03656.13 EDK38458.1 - 1.3e-33 115.8 0.2 1.5e-33 115.5 0.2 1.0 1 0 0 1 1 1 1 Pam16 PHD PF00628.29 EDK38459.2 - 3.3e-07 30.1 10.2 6.5e-07 29.2 10.2 1.5 1 0 0 1 1 1 1 PHD-finger DUF1388 PF07142.12 EDK38459.2 - 0.0009 19.1 4.1 0.0028 17.6 4.1 1.9 1 0 0 1 1 1 1 Repeat of unknown function (DUF1388) LRR_8 PF13855.6 EDK38460.2 - 2.5e-10 40.0 16.9 9.2e-06 25.3 4.8 3.7 2 2 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EDK38460.2 - 2.5e-09 37.2 14.5 4.1e-05 23.8 3.2 5.5 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK38460.2 - 6.8e-06 25.7 15.4 0.35 11.0 0.0 6.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.33 EDK38460.2 - 0.085 13.5 15.8 28 5.8 2.6 6.1 4 2 1 5 5 5 0 Leucine Rich Repeat FNIP PF05725.12 EDK38460.2 - 0.47 10.7 6.6 4.2 7.6 0.7 3.0 1 1 2 3 3 3 0 FNIP Repeat F-box PF00646.33 EDK38460.2 - 3.7 7.5 5.4 1.4 8.9 0.3 3.1 3 0 0 3 3 3 0 F-box domain ABC_membrane PF00664.23 EDK38461.2 - 1.4e-61 208.6 48.0 2.6e-36 125.7 24.4 2.6 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK38461.2 - 2.7e-49 167.2 0.6 4.2e-29 101.8 0.0 3.1 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK38461.2 - 3.5e-07 29.9 8.0 0.0086 15.5 0.5 4.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDK38461.2 - 9.8e-07 28.4 0.7 0.0085 15.8 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDK38461.2 - 2.6e-05 24.2 11.5 0.19 11.5 0.0 4.4 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EDK38461.2 - 0.00021 21.4 2.0 0.23 11.6 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK38461.2 - 0.00069 19.6 1.8 0.51 10.2 0.7 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK38461.2 - 0.00077 19.9 0.1 0.099 13.0 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EDK38461.2 - 0.0052 16.5 1.5 0.81 9.4 0.1 2.8 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EDK38461.2 - 0.014 15.9 5.5 0.86 10.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDK38461.2 - 0.025 13.9 0.0 2.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Vps51 PF08700.11 EDK38461.2 - 0.056 13.5 1.4 0.34 11.0 0.2 2.8 3 0 0 3 3 2 0 Vps51/Vps67 cobW PF02492.19 EDK38461.2 - 0.056 13.0 1.8 0.55 9.8 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EDK38461.2 - 0.059 13.6 2.8 9.6 6.5 0.2 3.4 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK38461.2 - 0.061 12.7 0.1 2.4 7.4 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EDK38461.2 - 0.08 13.4 21.9 0.23 11.9 0.0 3.9 2 1 1 3 3 2 0 AAA domain MeaB PF03308.16 EDK38461.2 - 0.083 11.9 0.3 9.8 5.1 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 EDK38461.2 - 0.12 12.1 0.0 16 5.1 0.0 2.9 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 EDK38461.2 - 0.12 12.4 0.1 0.12 12.4 0.1 2.2 2 0 0 2 2 1 0 Helicase HerA, central domain T2SSE PF00437.20 EDK38461.2 - 0.21 10.6 0.7 0.93 8.5 0.2 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein MFS_1 PF07690.16 EDK38462.2 - 4.4e-20 71.9 41.7 2.2e-12 46.6 10.5 2.4 1 1 2 3 3 3 3 Major Facilitator Superfamily Trehalase PF01204.18 EDK38463.2 - 3.2e-177 590.4 2.6 3.9e-177 590.2 2.6 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EDK38463.2 - 7.8e-18 63.9 0.3 1.4e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain polyprenyl_synt PF00348.17 EDK38464.2 - 2.2e-69 233.4 0.0 7e-63 212.1 0.0 2.5 2 1 0 2 2 2 2 Polyprenyl synthetase MKT1_C PF12246.8 EDK38464.2 - 0.044 13.0 0.1 0.21 10.8 0.0 2.0 2 0 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication PhoU PF01895.19 EDK38464.2 - 0.14 12.7 0.0 0.55 10.7 0.0 2.0 1 0 0 1 1 1 0 PhoU domain Ribosomal_L3 PF00297.22 EDK38465.2 - 4.2e-19 68.8 3.5 3.8e-16 59.0 0.6 2.3 1 1 1 2 2 2 2 Ribosomal protein L3 Ribosomal_L6 PF00347.23 EDK38466.2 - 7.9e-21 74.5 3.6 2.3e-11 44.2 1.9 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S4 PF00163.19 EDK38467.2 - 2.6e-13 50.7 2.9 4.1e-13 50.0 2.5 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 EDK38467.2 - 1.7e-09 37.2 0.0 4.1e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 S4 domain Pox_A_type_inc PF04508.12 EDK38467.2 - 0.11 12.4 0.1 0.9 9.5 0.0 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat SKG6 PF08693.10 EDK38468.2 - 6.5e-07 28.7 0.0 1.2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain UPF0239 PF06783.11 EDK38468.2 - 0.28 11.4 0.8 1.8 8.8 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Ferric_reduct PF01794.19 EDK38469.2 - 1.3e-27 96.3 15.1 1.3e-27 96.3 15.1 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDK38469.2 - 8.1e-22 77.4 0.0 1.4e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDK38469.2 - 2.3e-19 70.1 0.0 3.8e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain BRD4_CDT PF17105.5 EDK38470.2 - 0.7 9.5 9.4 0.46 10.1 6.6 2.1 1 1 1 2 2 2 0 C-terminal domain of bromodomain protein 4 Acetyltransf_1 PF00583.25 EDK38471.2 - 5.5e-09 36.3 0.0 2.6e-08 34.1 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK38471.2 - 8.8e-06 26.1 0.0 1.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK38471.2 - 9.2e-05 22.4 0.0 0.00066 19.6 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK38471.2 - 0.024 14.7 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 EDK38471.2 - 0.14 12.3 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.7 EDK38472.2 - 4.3e-56 190.8 0.0 1.2e-55 189.3 0.0 1.8 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EDK38472.2 - 1.2e-06 29.1 1.6 4.1e-06 27.4 0.0 2.7 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Nup96 PF12110.8 EDK38472.2 - 0.016 14.3 2.1 0.11 11.6 0.0 2.5 2 0 0 2 2 2 0 Nuclear protein 96 SRF-TF PF00319.18 EDK38473.2 - 1.7e-21 75.4 0.0 2.8e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_S6e PF01092.19 EDK38474.1 - 1.3e-45 154.4 0.3 2.6e-45 153.5 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e VKG_Carbox PF05090.14 EDK38474.1 - 0.085 11.7 0.4 0.11 11.3 0.4 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase DUF4574 PF15141.6 EDK38474.1 - 0.16 11.9 5.5 0.26 11.2 5.5 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 zinc_ribbon_6 PF14599.6 EDK38475.2 - 1.2e-25 89.2 1.8 1.2e-25 89.2 1.8 4.3 3 1 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 EDK38475.2 - 4.3e-18 65.6 25.0 4.3e-18 65.6 25.0 3.8 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EDK38475.2 - 8e-07 29.3 8.4 8e-07 29.3 8.4 5.7 2 1 2 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK38475.2 - 1.6e-05 24.7 6.6 1.6e-05 24.7 6.6 5.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK38475.2 - 2.3e-05 24.3 10.6 2.3e-05 24.3 10.6 5.9 5 1 1 6 6 6 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDK38475.2 - 0.00012 21.9 9.4 0.00012 21.9 9.4 6.1 2 1 3 5 5 5 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EDK38475.2 - 0.0085 16.0 4.2 0.0085 16.0 4.2 6.2 4 2 3 7 7 7 1 Prokaryotic RING finger family 1 PRP21_like_P PF12230.8 EDK38476.2 - 9e-64 215.3 5.4 1.4e-63 214.7 5.4 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EDK38476.2 - 1e-26 92.6 0.0 3.1e-12 46.3 0.0 2.7 2 0 0 2 2 2 2 Surp module NIF PF03031.18 EDK38477.2 - 3.7e-45 153.5 0.2 1.7e-44 151.3 0.2 1.9 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase V-ATPase_H_C PF11698.8 EDK38478.2 - 0.014 15.5 0.5 3 8.0 0.0 3.5 2 1 1 3 3 3 0 V-ATPase subunit H Aminotran_1_2 PF00155.21 EDK38479.1 - 9.2e-73 245.5 0.0 1e-72 245.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II zf-C2H2 PF00096.26 EDK38480.2 - 1.4e-05 25.2 20.6 3.4e-05 24.0 1.5 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK38480.2 - 1.7e-05 25.0 2.4 1.7e-05 25.0 2.4 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK38480.2 - 0.00011 22.8 17.1 0.0015 19.2 0.4 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK38480.2 - 0.021 14.9 0.5 0.021 14.9 0.5 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EDK38480.2 - 0.8 10.2 7.3 9.1 6.8 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ldh_1_C PF02866.18 EDK38481.1 - 1.4e-49 168.2 0.2 4.3e-49 166.6 0.4 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDK38481.1 - 1.1e-44 152.0 0.1 1.8e-44 151.2 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDK38481.1 - 0.0023 17.0 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EDK38481.1 - 0.014 14.7 0.1 0.13 11.5 0.0 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ins134_P3_kin PF05770.11 EDK38481.1 - 0.14 11.6 0.1 0.24 10.9 0.1 1.3 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Tau95 PF09734.9 EDK38482.2 - 4.4e-40 137.7 0.3 4.4e-40 137.7 0.3 2.3 3 0 0 3 3 3 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EDK38482.2 - 1.2e-32 112.8 0.3 3e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 Tau95 Triple barrel domain VTC PF09359.10 EDK38482.2 - 0.0044 16.5 0.1 0.0044 16.5 0.1 1.6 2 0 0 2 2 2 1 VTC domain DPM3 PF08285.11 EDK38483.1 - 1.4e-32 111.8 0.1 1.5e-32 111.6 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) GSAP-16 PF14959.6 EDK38483.1 - 0.057 13.3 0.4 0.067 13.1 0.4 1.4 1 1 0 1 1 1 0 gamma-Secretase-activating protein C-term ABC2_membrane_3 PF12698.7 EDK38483.1 - 0.11 11.6 0.2 0.13 11.4 0.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Oxidored-like PF09791.9 EDK38484.2 - 1.7e-24 85.2 1.5 1.7e-24 85.2 1.5 1.9 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal PHO4 PF01384.20 EDK38485.2 - 1.4e-116 389.2 18.7 1.7e-116 389.0 18.7 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4225 PF13988.6 EDK38485.2 - 0.045 13.3 2.0 0.53 9.8 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4225) F_actin_cap_B PF01115.17 EDK38486.2 - 2.6e-90 302.2 0.1 3e-90 302.0 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit TDA11 PF17084.5 EDK38487.2 - 9.2e-09 34.8 31.1 1.2e-08 34.4 21.0 2.8 2 1 0 2 2 2 1 Topoisomerase I damage affected protein 11 Clathrin_lg_ch PF01086.17 EDK38489.2 - 4.9e-53 180.5 20.8 6e-53 180.3 20.8 1.1 1 0 0 1 1 1 1 Clathrin light chain DUF5630 PF18632.1 EDK38489.2 - 0.015 14.7 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5630) DUF3492 PF11997.8 EDK38489.2 - 0.021 14.6 2.1 0.027 14.2 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Phosducin PF02114.16 EDK38489.2 - 0.059 12.3 4.0 0.12 11.3 3.8 1.5 1 1 0 1 1 1 0 Phosducin TK PF00265.18 EDK38489.2 - 0.11 12.3 0.5 0.16 11.8 0.5 1.2 1 0 0 1 1 1 0 Thymidine kinase MFA1_2 PF17317.2 EDK38489.2 - 3.8 7.4 5.7 0.86 9.4 0.9 2.5 2 1 0 2 2 2 0 Mating hormone A-factor 1&2 DUF5102 PF17104.5 EDK38489.2 - 4.4 7.3 15.4 7.8 6.5 15.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5102) O-antigen_lig PF13425.6 EDK38489.2 - 4.7 5.9 4.3 6.8 5.3 4.3 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein F-box-like PF12937.7 EDK38490.2 - 2.3e-08 33.8 0.0 5.9e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK38490.2 - 1.2e-05 25.0 0.1 3.7e-05 23.5 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EDK38490.2 - 0.15 12.0 0.4 0.42 10.5 0.0 2.0 2 0 0 2 2 2 0 F-box PH_9 PF15410.6 EDK38491.2 - 1.6e-05 25.3 0.0 0.00058 20.2 0.0 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDK38491.2 - 0.022 15.3 0.2 0.64 10.6 0.0 2.9 2 1 1 3 3 3 0 PH domain Polyketide_cyc PF03364.20 EDK38492.2 - 3.9e-21 75.6 0.1 4.8e-21 75.3 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EDK38492.2 - 0.02 15.2 0.0 0.03 14.6 0.0 1.5 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Ribosomal_S25 PF03297.15 EDK38493.1 - 6.5e-38 129.0 4.1 7.3e-38 128.8 4.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 EDK38493.1 - 0.0028 17.4 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain DUF365 PF04033.12 EDK38493.1 - 0.017 15.4 0.1 0.025 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF365) Ran_BP1 PF00638.18 EDK38494.2 - 5.5e-24 84.8 0.1 1e-23 83.9 0.1 1.5 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 EDK38494.2 - 1.1e-12 48.4 1.2 1.1e-12 48.4 1.2 4.6 4 1 0 4 4 4 1 NUP50 (Nucleoporin 50 kDa) WH1 PF00568.23 EDK38494.2 - 0.0046 16.9 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 1 WH1 domain PDGLE PF13190.6 EDK38494.2 - 0.069 13.1 0.7 7 6.6 0.0 2.7 2 0 0 2 2 2 0 PDGLE domain SBE2 PF17076.5 EDK38495.2 - 1.5e-05 23.5 16.7 7.6e-05 21.2 16.7 1.9 1 1 0 1 1 1 1 SBE2, cell-wall formation Dynactin PF12455.8 EDK38495.2 - 0.029 13.6 0.2 0.045 13.0 0.2 1.2 1 0 0 1 1 1 0 Dynein associated protein DnaJ_C PF01556.18 EDK38496.2 - 4.6e-29 101.4 0.4 7e-29 100.8 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDK38496.2 - 1e-23 83.2 6.8 2e-23 82.3 6.8 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDK38496.2 - 3.1e-11 43.5 22.1 5e-11 42.8 22.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrome_C7 PF14522.6 EDK38496.2 - 0.18 11.9 6.3 0.22 11.6 0.4 2.4 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c zf-CHY PF05495.12 EDK38496.2 - 0.95 10.0 4.5 0.35 11.4 1.4 1.8 1 1 1 2 2 2 0 CHY zinc finger Anti-TRAP PF15777.5 EDK38496.2 - 4.8 7.2 21.5 2.5 8.1 4.2 3.1 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein AcetylCoA_hydro PF02550.15 EDK38497.1 - 5.1e-66 222.4 0.0 9.5e-66 221.5 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EDK38497.1 - 6.1e-45 152.9 0.0 9.1e-45 152.3 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CoA_trans PF01144.23 EDK38497.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.7 1 0 0 1 1 1 0 Coenzyme A transferase DUF3835 PF12927.7 EDK38498.2 - 1.2e-09 38.9 0.7 1.2e-09 38.9 0.7 5.2 6 1 0 6 6 6 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 EDK38498.2 - 6.4e-07 29.3 0.1 2.4e-06 27.5 0.1 2.1 1 0 0 1 1 1 1 Prefoldin subunit TBCA PF02970.16 EDK38499.1 - 6.6e-22 77.7 9.5 7.4e-22 77.5 9.5 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A Efg1 PF10153.9 EDK38499.1 - 0.0088 16.4 2.9 0.01 16.2 2.9 1.1 1 0 0 1 1 1 1 rRNA-processing protein Efg1 ATP_bind_1 PF03029.17 EDK38500.2 - 1.1e-73 248.0 0.0 1.4e-73 247.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EDK38500.2 - 0.006 16.5 0.0 4.3 7.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EDK38500.2 - 0.018 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EDK38500.2 - 0.019 14.8 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop GTP_EFTU PF00009.27 EDK38500.2 - 0.072 12.6 0.0 20 4.6 0.0 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EDK38500.2 - 0.2 11.8 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain MitMem_reg PF13012.6 EDK38501.2 - 4.2e-33 114.1 0.8 8.6e-33 113.1 0.8 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EDK38501.2 - 1.6e-30 105.5 0.0 2.7e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.18 EDK38502.2 - 6.2e-51 173.1 12.7 1.1e-50 172.3 12.7 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family Hexokinase_1 PF00349.21 EDK38503.2 - 3.9e-73 245.6 0.1 7.5e-73 244.7 0.1 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.16 EDK38503.2 - 1.6e-72 243.8 0.0 2.2e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Glutaredoxin PF00462.24 EDK38504.2 - 3.5e-05 23.9 0.0 6.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EDK38504.2 - 0.0032 17.9 0.6 0.016 15.6 0.2 2.2 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EDK38504.2 - 0.022 14.5 0.1 0.033 13.9 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin Cytochrom_c3_2 PF14537.6 EDK38504.2 - 0.026 15.0 0.4 0.037 14.5 0.4 1.2 1 0 0 1 1 1 0 Cytochrome c3 Cytochrom_NNT PF03264.14 EDK38504.2 - 0.064 12.9 1.6 0.091 12.5 1.6 1.3 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region DUF953 PF06110.11 EDK38504.2 - 0.16 11.6 0.7 0.22 11.1 0.7 1.6 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) SHMT PF00464.19 EDK38505.1 - 1.9e-208 691.9 0.1 2.2e-208 691.7 0.1 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EDK38505.1 - 2.9e-07 30.0 0.0 9.4e-07 28.3 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDK38505.1 - 0.00053 19.1 0.0 0.00078 18.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDK38505.1 - 0.00074 18.9 0.0 0.0012 18.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EDK38505.1 - 0.069 11.7 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 EDK38505.1 - 0.1 11.3 0.0 0.23 10.1 0.0 1.6 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain DUF4559 PF15112.6 EDK38505.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF2340 PF10209.9 EDK38505.1 - 0.12 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) Cut12 PF11500.8 EDK38505.1 - 0.18 11.7 0.1 0.33 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle pole body formation-associated protein ORMDL PF04061.14 EDK38506.1 - 1.5e-55 186.7 5.2 1.9e-55 186.4 5.2 1.1 1 0 0 1 1 1 1 ORMDL family RCC1_2 PF13540.6 EDK38507.2 - 7.1e-21 73.5 3.4 6.2e-10 38.6 0.1 6.0 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDK38507.2 - 4.6e-16 59.2 0.6 0.0079 16.8 0.1 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat bZIP_1 PF00170.21 EDK38508.2 - 3.8e-07 30.1 6.6 3.8e-07 30.1 6.6 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EDK38508.2 - 4.4e-06 26.7 9.2 4.4e-06 26.7 9.2 1.9 1 1 1 2 2 2 1 Basic region leucine zipper DUF4637 PF15470.6 EDK38508.2 - 0.011 15.5 0.8 0.011 15.5 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) bZIP_Maf PF03131.17 EDK38508.2 - 0.015 15.8 4.9 0.028 14.9 4.9 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Hormone_3 PF00159.18 EDK38509.2 - 0.24 11.5 1.6 13 6.0 0.2 2.8 2 0 0 2 2 2 0 Pancreatic hormone peptide AhpC-TSA PF00578.21 EDK38510.2 - 1.5e-25 89.5 0.0 2.7e-25 88.7 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK38510.2 - 1.9e-19 69.8 0.0 2.6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EDK38510.2 - 0.0015 18.6 0.0 0.0025 17.9 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme Metallophos PF00149.28 EDK38511.2 - 6.9e-06 26.7 12.6 3.6e-05 24.4 12.6 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase OSCP PF00213.18 EDK38512.2 - 8.9e-47 159.4 3.7 1e-46 159.2 3.7 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Ribosomal_L2_C PF03947.18 EDK38513.1 - 1.6e-50 170.6 5.8 2e-50 170.2 4.7 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDK38513.1 - 3.6e-25 87.7 0.7 9.2e-25 86.4 0.7 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain TPP1 PF10341.9 EDK38514.2 - 1.1e-23 83.3 0.1 1.7e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Lactamase_B_4 PF13691.6 EDK38515.2 - 1.3e-26 92.0 0.1 2.8e-26 91.0 0.1 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EDK38515.2 - 0.00026 20.6 0.2 0.45 10.0 0.0 2.4 2 0 0 2 2 2 2 Beta-lactamase superfamily domain DUF2183 PF09949.9 EDK38515.2 - 0.041 14.2 0.2 12 6.4 0.0 3.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2183) Cnl2_NKP2 PF09447.10 EDK38515.2 - 0.15 12.2 1.1 0.97 9.6 0.2 2.8 3 0 0 3 3 3 0 Cnl2/NKP2 family protein DUF3336 PF11815.8 EDK38516.2 - 5.9e-35 120.0 1.5 1.3e-34 118.9 1.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDK38516.2 - 3.9e-20 72.9 0.0 9.3e-20 71.7 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase Zip PF02535.22 EDK38517.2 - 3.1e-24 85.8 10.7 9.7e-16 57.9 3.1 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter DUF4064 PF13273.6 EDK38517.2 - 0.4 11.0 9.3 3.9 7.8 0.6 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) F-box PF00646.33 EDK38518.2 - 2.8e-07 30.3 0.1 1.1e-06 28.3 0.1 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDK38518.2 - 9.4e-06 25.4 0.1 2.6e-05 24.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.17 EDK38518.2 - 0.00028 20.8 0.5 0.5 10.6 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK38518.2 - 0.00087 19.0 1.6 0.024 14.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38518.2 - 0.0026 18.0 0.1 1.3 9.4 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat HHH_8 PF14716.6 EDK38518.2 - 0.062 13.7 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain TPR_7 PF13176.6 EDK38518.2 - 0.07 13.2 0.1 6 7.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP13 PF12921.7 EDK38518.2 - 0.2 11.5 2.6 8 6.4 0.0 3.2 3 1 1 4 4 4 0 Mitochondrial ATPase expression LRR_6 PF13516.6 EDK38518.2 - 0.27 11.4 2.7 0.32 11.2 0.1 2.8 2 0 0 2 2 2 0 Leucine Rich repeat U3_snoRNA_assoc PF08297.11 EDK38519.2 - 6e-18 65.4 1.1 6e-18 65.4 1.1 3.3 2 1 0 2 2 2 1 U3 snoRNA associated ATG11 PF10377.9 EDK38519.2 - 0.69 10.0 6.0 2.7 8.1 6.0 2.0 1 1 0 1 1 1 0 Autophagy-related protein 11 FAM163 PF15069.6 EDK38520.2 - 3 8.3 7.9 5.6 7.4 1.1 2.3 2 0 0 2 2 2 0 FAM163 family NMT1 PF09084.11 EDK38521.1 - 1.2e-77 260.7 0.0 1.4e-77 260.5 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EDK38521.1 - 0.028 14.1 0.0 2.5 7.7 0.0 2.4 3 0 0 3 3 3 0 NMT1-like family PTS_2-RNA PF01885.16 EDK38522.2 - 3.1e-62 209.8 0.1 3.5e-62 209.7 0.1 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Complex1_LYR PF05347.15 EDK38523.2 - 4.5e-05 23.4 0.3 7.1e-05 22.8 0.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Utp8 PF10395.9 EDK38524.2 - 1.1e-186 622.4 3.0 1.2e-186 622.2 3.0 1.0 1 0 0 1 1 1 1 Utp8 family HAD_2 PF13419.6 EDK38525.1 - 7.8e-16 58.7 0.0 1.3e-15 57.9 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK38525.1 - 4.7e-12 46.6 0.0 1e-07 32.5 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDK38525.1 - 0.00017 22.0 0.0 0.00033 21.1 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDK38525.1 - 0.0003 20.8 0.2 0.00057 19.9 0.2 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EDK38525.1 - 0.019 15.0 0.1 0.22 11.7 0.1 2.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Phage_attach PF05354.11 EDK38525.1 - 0.063 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Phage Head-Tail Attachment Ribosomal_L23 PF00276.20 EDK38526.1 - 3.8e-16 59.2 2.9 1.7e-15 57.1 2.9 1.8 1 1 0 1 1 1 1 Ribosomal protein L23 USP7_ICP0_bdg PF12436.8 EDK38526.1 - 0.031 13.6 0.1 0.031 13.6 0.1 1.1 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 Ribosomal_S11 PF00411.19 EDK38527.2 - 6.8e-05 23.2 0.0 0.00011 22.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Pkinase PF00069.25 EDK38528.1 - 4.1e-56 190.3 0.0 5.1e-56 190.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38528.1 - 5.3e-26 91.5 0.0 7.2e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK38528.1 - 0.0002 20.8 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK38528.1 - 0.002 17.5 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0220 PF05255.11 EDK38529.1 - 1.9e-71 239.0 5.9 2.2e-71 238.8 5.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) WD40 PF00400.32 EDK38530.2 - 4.8e-32 109.5 14.3 1.1e-05 26.1 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38530.2 - 1.3e-19 70.3 0.1 0.0012 19.1 0.1 6.0 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK38530.2 - 2.2e-07 30.2 0.1 0.032 13.2 0.1 4.3 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDK38530.2 - 7e-07 28.3 0.6 0.4 9.2 0.0 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EDK38530.2 - 1.4e-06 27.6 0.1 0.0071 15.4 0.1 2.3 2 0 0 2 2 2 2 Coatomer WD associated region PQQ_3 PF13570.6 EDK38530.2 - 1.8e-05 25.1 1.0 0.05 14.1 0.0 3.6 4 0 0 4 4 3 2 PQQ-like domain WD40_like PF17005.5 EDK38530.2 - 4.2e-05 23.0 2.5 0.0035 16.7 0.0 3.7 1 1 3 5 5 5 1 WD40-like domain Cytochrom_D1 PF02239.16 EDK38530.2 - 0.00068 18.3 0.7 0.064 11.8 0.1 2.8 2 1 0 2 2 2 1 Cytochrome D1 heme domain PQQ PF01011.21 EDK38530.2 - 0.0019 18.0 1.4 10 6.3 0.1 4.3 4 0 0 4 4 4 1 PQQ enzyme repeat MMS1_N PF10433.9 EDK38530.2 - 0.004 15.9 0.0 0.086 11.5 0.0 2.6 1 1 2 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Frtz PF11768.8 EDK38530.2 - 0.022 13.1 0.0 0.22 9.8 0.0 2.2 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 EDK38530.2 - 0.023 13.6 0.5 0.096 11.6 0.1 2.2 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Pkinase PF00069.25 EDK38532.2 - 9.8e-65 218.5 0.0 3e-64 217.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38532.2 - 8.1e-44 149.8 0.0 1.7e-43 148.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK38532.2 - 2e-08 33.5 0.9 1.9e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDK38532.2 - 1.1e-05 24.9 0.0 2.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDK38532.2 - 0.0027 16.7 0.0 0.0074 15.3 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDK38532.2 - 0.038 13.3 0.0 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CorA PF01544.18 EDK38533.2 - 4.8e-05 22.8 4.5 7.8e-05 22.1 4.5 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EDK38533.2 - 0.012 14.4 0.3 0.018 13.8 0.3 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF960 PF06124.11 EDK38533.2 - 0.042 14.5 0.3 0.81 10.4 0.0 3.0 3 1 0 3 3 3 0 Staphylococcal protein of unknown function (DUF960) RhoGAP PF00620.27 EDK38534.2 - 0.0001 22.2 0.6 0.00026 20.8 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain Med30 PF11315.8 EDK38534.2 - 0.0085 16.3 2.8 0.13 12.4 0.1 2.7 2 0 0 2 2 2 1 Mediator complex subunit 30 Snapin_Pallidin PF14712.6 EDK38534.2 - 0.009 16.4 1.2 0.043 14.2 0.0 2.6 2 0 0 2 2 2 1 Snapin/Pallidin rve_3 PF13683.6 EDK38534.2 - 0.04 13.7 0.0 0.28 11.0 0.0 2.6 2 0 0 2 2 2 0 Integrase core domain CENP-O PF09496.10 EDK38535.2 - 1.7e-17 64.1 3.3 7.2e-17 62.1 0.4 2.5 2 1 0 2 2 2 1 Cenp-O kinetochore centromere component ERM PF00769.19 EDK38535.2 - 0.058 13.2 0.5 0.082 12.7 0.5 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.15 EDK38535.2 - 0.066 13.0 1.1 0.15 11.9 0.8 1.7 2 0 0 2 2 2 0 Septum formation initiator Clathrin PF00637.20 EDK38536.2 - 4.2e-186 610.3 52.3 5.9e-32 110.5 0.4 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EDK38536.2 - 3.5e-27 94.1 2.3 8.1e-27 92.9 0.8 2.6 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EDK38536.2 - 2.2e-23 81.3 5.6 0.0095 16.2 0.0 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin-link PF09268.10 EDK38536.2 - 4.8e-07 29.0 0.0 1.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_1 PF00515.28 EDK38536.2 - 0.00013 21.6 3.0 23 5.0 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDK38536.2 - 0.0013 18.6 1.2 87 3.5 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38536.2 - 0.0093 16.0 10.7 7 7.0 0.0 7.0 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38536.2 - 0.012 15.9 4.5 38 4.7 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat Utp13 PF08625.11 EDK38536.2 - 0.088 12.7 2.4 0.3 11.0 0.1 3.1 3 0 0 3 3 3 0 Utp13 specific WD40 associated domain TPR_10 PF13374.6 EDK38536.2 - 0.11 12.4 1.0 19 5.3 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SPOB_a PF14689.6 EDK38536.2 - 0.13 12.0 5.1 0.27 11.0 0.0 3.8 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain Vps39_1 PF10366.9 EDK38536.2 - 0.53 10.6 12.9 21 5.5 0.2 6.5 6 2 1 7 7 6 0 Vacuolar sorting protein 39 domain 1 TPR_8 PF13181.6 EDK38536.2 - 9.7 6.7 10.3 39 4.8 0.1 6.5 8 0 0 8 8 7 0 Tetratricopeptide repeat Vfa1 PF08432.10 EDK38537.2 - 0.0037 17.6 0.1 0.0064 16.8 0.1 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 EDK38537.2 - 0.025 12.9 0.3 0.037 12.4 0.3 1.2 1 0 0 1 1 1 0 CDC45-like protein SIT PF15330.6 EDK38537.2 - 0.16 12.5 0.4 19 5.7 0.2 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EIIBC-GUT_N PF03612.14 EDK38537.2 - 0.81 9.4 2.5 1.5 8.5 2.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TFIIA PF03153.13 EDK38538.2 - 0.83 9.6 21.3 1 9.3 21.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2868 PF11067.8 EDK38538.2 - 6.9 6.1 6.4 29 4.0 3.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) LIM PF00412.22 EDK38539.2 - 3.5e-16 59.2 21.3 2.9e-09 37.0 6.5 2.6 2 1 0 2 2 2 2 LIM domain zf-RRN7 PF11781.8 EDK38539.2 - 0.0074 16.0 0.4 0.0074 16.0 0.4 2.4 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DiS_P_DiS PF06750.13 EDK38539.2 - 4.6 7.4 7.1 64 3.8 0.1 2.8 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain SNARE_assoc PF09335.11 EDK38540.2 - 4.4e-18 65.9 6.5 4.4e-18 65.9 6.5 2.4 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF2207 PF09972.9 EDK38540.2 - 0.093 11.5 1.6 0.2 10.4 1.6 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TRIQK PF15168.6 EDK38540.2 - 0.13 12.2 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family DUF4231 PF14015.6 EDK38540.2 - 1.2 9.7 4.0 12 6.4 0.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) PsbU PF06514.11 EDK38541.1 - 0.033 14.2 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) MFS_1 PF07690.16 EDK38542.2 - 3.4e-18 65.7 14.8 8.8e-10 38.0 13.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK38542.2 - 1.4e-16 60.5 7.0 2.5e-16 59.6 7.0 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EDK38542.2 - 0.0062 15.4 1.2 0.0062 15.4 1.2 2.1 2 0 0 2 2 2 1 MFS_1 like family Esterase PF00756.20 EDK38543.2 - 4.4e-45 154.3 0.1 5.3e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 EDK38543.2 - 1.5e-09 37.2 0.0 2e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EDK38543.2 - 0.00025 20.2 0.0 0.033 13.2 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase Peptidase_S9 PF00326.21 EDK38543.2 - 0.00027 20.5 0.3 0.00042 19.9 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDK38543.2 - 0.0099 15.2 0.0 0.019 14.3 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EDK38543.2 - 0.031 14.2 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) GCIP PF13324.6 EDK38544.2 - 2.2e-19 70.1 1.1 3.2e-19 69.6 1.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF4041 PF13250.6 EDK38544.2 - 0.03 14.2 0.0 1.9 8.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) SCHIP-1 PF10148.9 EDK38544.2 - 0.066 12.8 0.2 0.12 12.0 0.2 1.4 1 1 0 1 1 1 0 Schwannomin-interacting protein 1 Cdh1_DBD_1 PF18196.1 EDK38545.2 - 0.81 10.0 4.1 16 5.9 1.6 2.1 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 WH1 PF00568.23 EDK38546.2 - 1e-28 99.4 0.0 2e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 WH1 domain TMA7 PF09072.10 EDK38547.1 - 3.9e-24 85.2 19.3 4.3e-24 85.1 19.3 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Ribosomal_L17 PF01196.19 EDK38548.2 - 3.6e-21 75.9 0.2 5.7e-21 75.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Mrpl_C PF18502.1 EDK38548.2 - 0.0078 16.5 0.2 0.018 15.3 0.2 1.5 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain TPX2_importin PF12214.8 EDK38548.2 - 0.087 13.0 0.2 0.087 13.0 0.2 1.7 2 0 0 2 2 2 0 Cell cycle regulated microtubule associated protein adh_short PF00106.25 EDK38549.2 - 8.4e-32 110.2 0.0 1e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK38549.2 - 1.9e-20 73.4 0.0 2.4e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK38549.2 - 3.1e-11 43.5 0.0 4.7e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EDK38549.2 - 0.001 19.1 0.1 0.0019 18.3 0.1 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 EDK38549.2 - 0.004 16.5 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Exog_C PF18026.1 EDK38549.2 - 0.028 14.5 0.1 3.3 7.8 0.1 2.6 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Epimerase PF01370.21 EDK38549.2 - 0.048 13.1 0.0 0.096 12.1 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Phage_holin_2_1 PF04971.12 EDK38549.2 - 0.075 13.0 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 Bacteriophage P21 holin S DUF1776 PF08643.10 EDK38549.2 - 0.091 12.1 0.0 0.4 10.0 0.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.18 EDK38549.2 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EDK38549.2 - 0.12 11.5 0.3 0.43 9.6 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_10 PF13460.6 EDK38549.2 - 0.13 12.1 0.0 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding AIM5 PF17050.5 EDK38550.2 - 6.2e-13 49.3 0.1 8.7e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 MRP-L47 PF06984.13 EDK38551.2 - 4e-16 58.9 0.7 6.8e-16 58.2 0.7 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Strabismus PF06638.11 EDK38551.2 - 0.00017 20.4 3.0 0.00022 20.0 3.0 1.1 1 0 0 1 1 1 1 Strabismus protein ApoLp-III PF07464.11 EDK38551.2 - 0.087 12.9 2.8 0.17 12.0 2.8 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Complex1_LYR_2 PF13233.6 EDK38551.2 - 0.15 12.8 2.6 0.33 11.7 2.6 1.7 1 0 0 1 1 1 0 Complex1_LYR-like STAT_alpha PF01017.20 EDK38552.2 - 0.015 15.2 2.7 0.038 13.9 2.7 1.6 1 0 0 1 1 1 0 STAT protein, all-alpha domain DUF3213 PF11491.8 EDK38552.2 - 0.5 10.6 5.3 0.75 10.0 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3213) Sec39 PF08314.11 EDK38553.2 - 2.4e-53 181.8 4.9 4e-53 181.0 4.9 1.3 1 0 0 1 1 1 1 Secretory pathway protein Sec39 PIF1 PF05970.14 EDK38554.2 - 3.1e-58 197.7 2.4 3.6e-55 187.6 2.4 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 EDK38554.2 - 1.1e-21 77.4 0.0 1.9e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK38554.2 - 2.1e-09 37.9 0.0 5.2e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EDK38554.2 - 0.00016 22.1 0.1 0.00057 20.3 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EDK38554.2 - 0.00033 20.2 0.0 0.00086 18.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 EDK38554.2 - 0.00046 18.2 0.1 0.037 11.9 0.0 2.1 2 0 0 2 2 2 2 Helicase AAA_22 PF13401.6 EDK38554.2 - 0.00055 20.2 0.0 0.0024 18.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDK38554.2 - 0.0032 16.8 0.2 0.027 13.7 0.2 2.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EDK38554.2 - 0.0039 16.3 0.1 0.0063 15.6 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 EDK38554.2 - 0.0043 17.1 2.3 0.51 10.4 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK38554.2 - 0.0059 17.0 0.1 0.015 15.6 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.14 EDK38554.2 - 0.0062 16.4 0.2 0.037 13.9 0.2 2.2 1 1 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 EDK38554.2 - 0.0085 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 EDK38554.2 - 0.015 14.8 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EDK38554.2 - 0.015 15.8 1.2 0.031 14.8 0.2 2.0 2 0 0 2 2 2 0 ABC transporter TrwB_AAD_bind PF10412.9 EDK38554.2 - 0.016 14.2 0.0 0.053 12.4 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 EDK38554.2 - 0.024 14.6 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 EDK38554.2 - 0.028 14.3 1.3 0.34 10.8 0.0 2.5 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EDK38554.2 - 0.044 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EDK38554.2 - 0.12 11.5 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain DEAD PF00270.29 EDK38555.2 - 0.003 17.4 0.0 0.0073 16.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase FANCI_S1-cap PF14674.6 EDK38555.2 - 0.25 11.5 1.4 1.2 9.3 0.5 2.6 2 0 0 2 2 2 0 FANCI solenoid 1 cap cNMP_binding PF00027.29 EDK38556.2 - 7e-22 77.3 0.0 1.5e-10 41.0 0.0 4.5 4 1 0 4 4 4 2 Cyclic nucleotide-binding domain Patatin PF01734.22 EDK38556.2 - 6.4e-20 72.2 1.1 2e-19 70.6 1.1 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Pam17 PF08566.10 EDK38557.2 - 8.8e-60 201.3 0.0 1e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 ThrE PF06738.12 EDK38557.2 - 0.03 13.7 0.3 0.053 12.9 0.2 1.4 1 1 0 1 1 1 0 Putative threonine/serine exporter SNF2_N PF00176.23 EDK38558.2 - 5.8e-70 235.7 0.6 5.8e-70 235.7 0.6 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK38558.2 - 4.4e-22 78.5 0.3 1.8e-19 70.1 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EDK38558.2 - 9.5e-20 70.5 0.0 2.7e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 Bromodomain ResIII PF04851.15 EDK38558.2 - 1.6e-12 47.7 0.1 1.6e-12 47.7 0.1 3.4 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit SnAC PF14619.6 EDK38558.2 - 9.2e-10 39.0 2.4 9.2e-10 39.0 2.4 3.7 2 1 1 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.13 EDK38558.2 - 3.4e-05 24.1 9.5 3.4e-05 24.1 9.5 2.7 2 0 0 2 2 2 1 HSA peroxidase PF00141.23 EDK38559.1 - 4.8e-35 121.3 0.0 9e-35 120.4 0.0 1.4 1 1 0 1 1 1 1 Peroxidase Ribosomal_L6 PF00347.23 EDK38560.1 - 1.6e-29 102.4 7.9 1.2e-15 58.0 1.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 YbbR PF07949.12 EDK38560.1 - 0.058 13.7 3.7 0.38 11.1 0.1 3.1 1 1 2 3 3 3 0 YbbR-like protein Med7 PF05983.11 EDK38561.2 - 1.8e-61 207.5 0.4 2.3e-61 207.2 0.4 1.1 1 0 0 1 1 1 1 MED7 protein Med4 PF10018.9 EDK38561.2 - 0.0029 17.3 1.4 0.0029 17.3 1.4 1.5 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF5063 PF16702.5 EDK38561.2 - 0.024 15.1 0.5 1.7 9.0 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5063) cwf21 PF08312.12 EDK38561.2 - 0.15 12.2 1.5 0.48 10.6 1.5 1.8 1 0 0 1 1 1 0 cwf21 domain Adaptin_N PF01602.20 EDK38562.2 - 2.7e-118 395.8 8.0 3.6e-118 395.4 8.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDK38562.2 - 1.9e-60 203.6 6.5 7.8e-60 201.6 0.3 3.6 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDK38562.2 - 5.4e-09 36.3 0.0 9.2e-05 22.8 0.0 4.3 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EDK38562.2 - 1.5e-08 34.2 0.1 0.14 12.5 0.0 5.1 4 0 0 4 4 4 3 HEAT repeat RIX1 PF08167.12 EDK38562.2 - 0.0031 17.3 0.0 1.6 8.4 0.0 3.8 2 2 0 3 3 3 1 rRNA processing/ribosome biogenesis Arm PF00514.23 EDK38562.2 - 0.026 14.5 3.7 9.8 6.4 0.0 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDK38562.2 - 0.037 14.5 0.0 5.9 7.5 0.0 3.8 3 0 0 3 3 3 0 HEAT-like repeat SPO22 PF08631.10 EDK38562.2 - 0.2 11.1 4.2 0.66 9.4 1.3 2.3 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like Gag_p24 PF00607.20 EDK38563.2 - 0.0015 18.4 0.1 0.0059 16.5 0.0 2.0 1 1 1 2 2 2 1 gag gene protein p24 (core nucleocapsid protein) Methyltransf_10 PF05971.12 EDK38564.2 - 6.9e-10 38.7 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase GP41 PF00517.17 EDK38564.2 - 0.37 10.7 2.9 1.5 8.7 0.3 2.1 1 1 1 2 2 2 0 Retroviral envelope protein Mog1 PF04603.12 EDK38565.2 - 8.9e-27 94.1 2.5 2e-25 89.7 2.5 2.2 1 1 0 1 1 1 1 Ran-interacting Mog1 protein NYN PF01936.18 EDK38565.2 - 0.075 13.5 0.1 0.13 12.8 0.1 1.4 1 1 0 1 1 1 0 NYN domain Gly_transf_sug PF04488.15 EDK38566.2 - 5e-14 52.7 0.0 1.2e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF3375 PF11855.8 EDK38566.2 - 0.016 14.2 2.2 0.024 13.6 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) DUF4179 PF13786.6 EDK38566.2 - 0.091 13.2 0.1 0.33 11.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Mto2_bdg PF12808.7 EDK38566.2 - 1.2 9.5 6.8 11 6.4 6.8 2.3 1 1 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region PIG-X PF08320.12 EDK38567.2 - 5.1e-42 144.2 0.0 1.4e-41 142.7 0.0 1.7 2 0 0 2 2 2 1 PIG-X / PBN1 FlgN PF05130.12 EDK38568.1 - 0.0029 18.1 3.9 0.0029 18.1 3.9 2.6 2 1 0 2 2 2 1 FlgN protein PglZ PF08665.12 EDK38568.1 - 0.16 12.0 7.6 0.075 13.1 0.9 2.2 1 1 1 2 2 2 0 PglZ domain DUF3037 PF11236.8 EDK38568.1 - 0.18 12.2 4.7 0.16 12.4 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) DUF948 PF06103.11 EDK38568.1 - 0.62 10.4 6.8 0.38 11.0 0.3 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Rx_N PF18052.1 EDK38568.1 - 0.69 10.2 10.6 0.037 14.3 3.1 2.4 2 1 0 2 2 2 0 Rx N-terminal domain PEP-utilisers_N PF05524.13 EDK38568.1 - 0.86 9.8 6.5 5.1 7.3 2.7 2.6 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF3602 PF12223.8 EDK38570.2 - 2.3e-26 92.2 22.4 2.3e-16 60.2 3.8 4.0 1 1 3 4 4 4 4 Protein of unknown function (DUF3602) NuA4 PF09340.10 EDK38570.2 - 0.084 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Ham1p_like PF01725.16 EDK38571.1 - 7.6e-54 182.5 0.0 8.5e-54 182.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family TPK_catalytic PF04263.16 EDK38572.2 - 1.3e-35 122.0 0.2 4.3e-35 120.4 0.2 1.8 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EDK38572.2 - 9.7e-11 41.2 1.8 1.6e-10 40.5 0.6 1.9 2 0 0 2 2 2 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TFIID-31kDa PF02291.15 EDK38573.2 - 1.8e-50 170.1 0.0 2.3e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit ChAPs PF09295.10 EDK38574.2 - 3.6e-159 530.0 0.0 5.7e-159 529.4 0.0 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 EDK38574.2 - 2.5e-06 27.9 0.1 5e-05 23.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38574.2 - 0.00022 21.1 0.6 3.9 7.8 0.1 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDK38574.2 - 0.00082 19.4 0.2 5.9 7.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK38574.2 - 0.0035 17.5 1.5 0.21 11.8 0.1 3.5 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EDK38574.2 - 0.012 16.2 0.2 0.18 12.5 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDK38574.2 - 0.056 13.8 0.8 4.5 7.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDK38574.2 - 0.14 12.0 0.4 42 4.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDK38574.2 - 0.17 12.8 1.8 5.1 8.2 0.0 3.9 3 1 2 5 5 5 0 Tetratricopeptide repeat HIG_1_N PF04588.13 EDK38575.1 - 5.5e-17 61.7 0.7 7.5e-17 61.3 0.7 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Guanylate_kin PF00625.21 EDK38576.2 - 2.1e-66 223.1 0.0 2.4e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EDK38576.2 - 5.4e-07 30.2 0.1 1.3e-06 28.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EDK38576.2 - 3e-06 27.4 0.1 3.3e-05 24.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK38576.2 - 5.7e-06 26.9 0.1 2.1e-05 25.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDK38576.2 - 7.7e-05 23.0 0.0 0.00021 21.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDK38576.2 - 0.00016 22.0 0.9 0.00066 20.0 0.9 2.1 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDK38576.2 - 0.00043 20.6 0.0 0.00086 19.7 0.0 1.5 2 0 0 2 2 1 1 RNA helicase ABC_tran PF00005.27 EDK38576.2 - 0.00046 20.7 0.0 0.00059 20.4 0.0 1.5 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 EDK38576.2 - 0.0014 18.7 0.0 0.0034 17.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATPase_2 PF01637.18 EDK38576.2 - 0.0019 18.2 0.0 0.0033 17.4 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Rad17 PF03215.15 EDK38576.2 - 0.0021 18.0 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EDK38576.2 - 0.0022 17.9 0.0 0.0044 16.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_24 PF13479.6 EDK38576.2 - 0.0023 17.7 0.2 0.044 13.5 0.1 2.2 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDK38576.2 - 0.0034 16.7 0.0 0.12 11.6 0.0 2.0 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EDK38576.2 - 0.0035 17.1 0.0 0.02 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDK38576.2 - 0.0047 17.0 0.0 0.024 14.7 0.0 2.1 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EDK38576.2 - 0.0048 16.8 0.0 0.0069 16.3 0.0 1.3 1 0 0 1 1 1 1 NTPase AAA PF00004.29 EDK38576.2 - 0.005 17.3 0.3 0.026 15.0 0.1 2.0 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EDK38576.2 - 0.0051 15.9 0.0 0.015 14.4 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EDK38576.2 - 0.0054 16.3 0.0 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_29 PF13555.6 EDK38576.2 - 0.0066 16.2 1.3 0.017 14.8 0.1 2.1 2 1 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EDK38576.2 - 0.0074 16.2 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 EDK38576.2 - 0.015 15.3 0.2 0.038 14.0 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EDK38576.2 - 0.018 14.6 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.6 EDK38576.2 - 0.025 14.9 0.0 0.57 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 EDK38576.2 - 0.034 13.0 0.1 0.049 12.4 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_2 PF07724.14 EDK38576.2 - 0.052 13.7 0.0 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Cytidylate_kin PF02224.18 EDK38576.2 - 0.077 12.7 0.1 0.17 11.6 0.0 1.6 2 0 0 2 2 1 0 Cytidylate kinase MobB PF03205.14 EDK38576.2 - 0.078 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Roc PF08477.13 EDK38576.2 - 0.091 13.0 0.1 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NAGLU_N PF12971.7 EDK38576.2 - 0.1 12.4 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain dNK PF01712.19 EDK38576.2 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_23 PF13476.6 EDK38576.2 - 0.24 11.9 2.2 0.46 10.9 2.2 1.8 1 1 0 1 1 1 0 AAA domain Xpo1 PF08389.12 EDK38577.2 - 6.1e-27 94.5 3.8 6.1e-27 94.5 3.8 3.9 3 1 1 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 EDK38577.2 - 9.1e-08 31.9 2.8 4e-07 29.9 1.0 3.0 2 1 1 3 3 3 1 Importin-beta N-terminal domain rpo30_N PF12410.8 EDK38577.2 - 0.011 15.7 0.0 0.067 13.1 0.0 2.3 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit IL2 PF00715.17 EDK38577.2 - 0.037 14.0 0.5 0.19 11.6 0.1 2.4 2 0 0 2 2 2 0 Interleukin 2 UME PF08064.13 EDK38577.2 - 0.098 12.6 3.0 8.3 6.4 0.0 4.4 4 1 0 4 4 4 0 UME (NUC010) domain HEAT PF02985.22 EDK38577.2 - 0.1 12.9 0.1 45 4.7 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat SRP54_N PF02881.19 EDK38578.1 - 1.3 9.3 7.9 5.8 7.2 1.2 3.4 1 1 2 3 3 3 0 SRP54-type protein, helical bundle domain HMA PF00403.26 EDK38579.2 - 5e-45 151.8 9.3 1.4e-14 54.2 0.1 4.4 4 0 0 4 4 4 3 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EDK38579.2 - 6.9e-45 152.8 0.0 6.9e-45 152.8 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EDK38579.2 - 7e-30 104.9 0.1 1.1e-29 104.2 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK38579.2 - 0.0014 18.4 2.0 0.03 14.1 1.1 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase FeS_assembly_P PF01883.19 EDK38579.2 - 0.0044 17.2 1.7 28 5.0 0.0 3.8 4 0 0 4 4 4 0 Iron-sulfur cluster assembly protein Arena_ncap_C PF17290.2 EDK38579.2 - 0.073 12.4 0.0 0.59 9.4 0.0 2.1 2 0 0 2 2 2 0 Arenavirus nucleocapsid C-terminal domain Vma12 PF11712.8 EDK38579.2 - 0.2 11.7 0.4 0.95 9.5 0.1 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase HAD PF12710.7 EDK38579.2 - 0.2 12.0 0.0 0.47 10.8 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 EDK38579.2 - 0.28 11.6 8.8 11 6.5 1.0 4.0 3 0 0 3 3 3 0 BFD-like [2Fe-2S] binding domain SART-1 PF03343.13 EDK38580.2 - 2.2e-43 148.8 65.6 7.4e-34 117.3 44.8 4.2 1 1 3 4 4 4 3 SART-1 family NDUFA12 PF05071.16 EDK38581.2 - 4.4e-07 30.7 12.0 4.4e-07 30.7 12.0 2.9 2 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Asp-B-Hydro_N PF05279.11 EDK38581.2 - 0.011 15.8 10.6 0.013 15.6 10.6 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PIEZO PF15917.5 EDK38581.2 - 8.7 5.7 14.1 12 5.3 14.1 1.1 1 0 0 1 1 1 0 Piezo PX PF00787.24 EDK38582.2 - 2.4e-15 56.5 0.0 3e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 PX domain SCIMP PF15050.6 EDK38582.2 - 0.069 13.6 0.3 0.13 12.7 0.3 1.5 1 1 0 1 1 1 0 SCIMP protein Pyr_redox_2 PF07992.14 EDK38583.2 - 9.4e-51 172.8 0.2 1.1e-50 172.6 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK38583.2 - 2.3e-20 73.1 0.1 5.2e-19 68.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK38583.2 - 5.4e-18 65.3 0.1 3e-15 56.5 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDK38583.2 - 0.00019 20.6 3.0 0.69 8.9 0.2 3.7 3 1 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EDK38583.2 - 0.0005 20.5 0.0 0.19 12.2 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 EDK38583.2 - 0.00079 19.6 0.1 0.027 14.7 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDK38583.2 - 0.0033 16.7 0.1 0.014 14.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EDK38583.2 - 0.0041 16.2 3.4 0.58 9.2 0.0 2.7 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 EDK38583.2 - 0.014 14.5 0.0 2.1 7.4 0.0 3.2 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EDK38583.2 - 0.026 13.8 0.0 3.8 6.6 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EDK38583.2 - 0.035 13.7 0.1 8.7 5.8 0.0 2.9 2 1 0 3 3 3 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EDK38583.2 - 0.1 12.6 0.1 17 5.4 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase SNARE PF05739.19 EDK38584.2 - 9e-15 54.4 0.9 2.7e-12 46.5 0.0 2.7 2 0 0 2 2 2 2 SNARE domain Syntaxin_2 PF14523.6 EDK38584.2 - 3.5e-05 24.1 22.5 0.00024 21.4 13.3 2.5 2 1 0 2 2 2 2 Syntaxin-like protein MCPsignal PF00015.21 EDK38584.2 - 0.019 14.8 3.1 0.83 9.4 1.0 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 EDK38584.2 - 0.33 11.0 11.3 0.17 11.9 2.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) GLE1 PF07817.13 EDK38584.2 - 0.45 9.7 5.4 0.6 9.3 0.4 2.3 2 0 0 2 2 2 0 GLE1-like protein G10 PF01125.17 EDK38584.2 - 0.51 10.1 6.6 57 3.4 6.6 2.6 1 1 0 1 1 1 0 G10 protein DUF883 PF05957.13 EDK38584.2 - 0.59 10.8 3.0 1.8 9.2 0.1 2.6 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Laminin_II PF06009.12 EDK38584.2 - 1.1 9.3 11.5 1.1 9.3 2.8 2.7 2 1 0 2 2 2 0 Laminin Domain II KxDL PF10241.9 EDK38584.2 - 3 8.2 15.7 3.3 8.1 2.0 3.7 3 1 1 4 4 4 0 Uncharacterized conserved protein HAD_2 PF13419.6 EDK38584.2 - 5.2 7.1 9.5 0.3 11.1 1.3 2.1 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase WD40 PF00400.32 EDK38585.2 - 4.3e-26 90.7 19.1 1.2e-05 25.9 0.4 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38585.2 - 1.7e-08 34.6 5.2 0.87 9.9 0.0 5.4 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDK38585.2 - 0.066 12.3 1.3 0.45 9.5 0.3 2.4 1 1 2 3 3 3 0 Coatomer WD associated region FAD_binding_6 PF00970.24 EDK38586.2 - 1.7e-06 28.3 0.3 1.2e-05 25.6 0.0 2.4 3 0 0 3 3 3 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDK38586.2 - 0.0029 18.2 0.1 4.4 8.0 0.0 2.7 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Hira PF07569.11 EDK38587.2 - 1.3e-79 267.0 2.3 1.6e-79 266.7 0.2 2.2 2 0 0 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.10 EDK38587.2 - 1.9e-09 37.1 2.3 5.1e-09 35.8 2.3 1.8 1 0 0 1 1 1 1 HIRA B motif WD40 PF00400.32 EDK38587.2 - 5.6e-09 36.5 11.4 0.98 10.4 0.1 7.2 6 1 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38587.2 - 1.2e-07 31.9 0.0 0.024 14.9 0.0 5.8 4 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDK38587.2 - 0.00066 19.1 0.1 1.3 8.3 0.0 3.9 3 1 1 4 4 4 1 WD40-like domain PD40 PF07676.12 EDK38587.2 - 0.0016 18.3 6.1 0.059 13.3 0.1 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EDK38587.2 - 0.12 11.5 0.0 1.4 7.8 0.0 2.6 2 1 2 4 4 4 0 Coatomer WD associated region CK_II_beta PF01214.18 EDK38588.2 - 6.6e-72 241.1 0.0 7.9e-72 240.9 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit tRNA-synt_1b PF00579.25 EDK38589.2 - 2.2e-68 230.7 0.0 3e-68 230.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) 3HCDH_N PF02737.18 EDK38589.2 - 0.12 12.3 0.4 0.34 10.8 0.4 1.7 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GATA PF00320.27 EDK38590.2 - 0.023 14.3 1.6 0.4 10.3 0.2 2.4 2 0 0 2 2 2 0 GATA zinc finger PNP_UDP_1 PF01048.20 EDK38591.2 - 6.2e-50 169.6 0.0 9.6e-50 169.0 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily DUF1690 PF07956.11 EDK38591.2 - 0.033 14.6 4.1 0.057 13.8 4.1 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) PAC2 PF09754.9 EDK38591.2 - 0.13 12.2 0.1 13 5.7 0.0 2.8 2 1 1 3 3 3 0 PAC2 family Atg14 PF10186.9 EDK38591.2 - 0.19 10.8 4.6 0.29 10.2 4.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Topoisom_I_N PF02919.15 EDK38591.2 - 0.35 10.3 4.8 0.61 9.6 4.8 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DIT1_PvcA PF05141.12 EDK38591.2 - 0.49 9.8 4.9 0.61 9.5 3.6 1.6 1 1 1 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein WD40 PF00400.32 EDK38592.2 - 5.9e-22 77.6 20.0 7e-05 23.5 0.2 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38592.2 - 1.9e-09 37.7 4.2 0.00083 19.6 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain THOC7 PF05615.13 EDK38593.2 - 0.0013 19.0 2.0 0.0034 17.7 1.1 1.9 1 1 1 2 2 2 1 Tho complex subunit 7 Med8 PF10232.9 EDK38593.2 - 0.031 13.9 1.8 0.056 13.0 1.7 1.5 1 1 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Serine_rich PF08824.10 EDK38593.2 - 0.063 13.3 1.6 0.27 11.2 0.1 2.3 1 1 0 2 2 2 0 Serine rich protein interaction domain MtrB PF05440.12 EDK38593.2 - 0.085 13.3 2.0 3.3 8.2 0.1 3.3 2 2 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B GCSF PF16647.5 EDK38593.2 - 0.089 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor DivIVA PF05103.13 EDK38593.2 - 0.1 12.7 2.5 0.22 11.6 0.1 2.3 2 0 0 2 2 2 0 DivIVA protein PIN_8 PF18476.1 EDK38593.2 - 0.47 10.3 3.9 4.5 7.1 0.9 2.1 1 1 1 2 2 2 0 PIN like domain MukF_M PF17192.4 EDK38594.2 - 0.043 13.6 0.2 0.088 12.5 0.2 1.5 1 0 0 1 1 1 0 MukF middle domain SelP_N PF04592.14 EDK38594.2 - 2 7.8 16.2 4 6.8 16.2 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Transp_cyt_pur PF02133.15 EDK38595.1 - 5.6e-142 473.6 25.9 6.5e-142 473.4 25.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Hydrolase_4 PF12146.8 EDK38596.2 - 1e-06 28.2 0.0 3.4e-05 23.2 0.0 2.8 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK38596.2 - 3.2e-06 27.0 0.0 4e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK38596.2 - 3.5e-06 27.8 0.0 1.2e-05 26.0 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EDK38596.2 - 0.052 13.2 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Ribosomal_S4e PF00900.20 EDK38596.2 - 0.06 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Ribosomal family S4e PLA2_B PF01735.18 EDK38597.2 - 1.9e-161 537.8 5.1 8e-161 535.8 5.1 1.8 1 1 0 1 1 1 1 Lysophospholipase catalytic domain IBR PF01485.21 EDK38597.2 - 0.012 15.9 1.9 0.037 14.2 1.9 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Nfu_N PF08712.11 EDK38598.2 - 1.9e-28 98.3 1.0 3.6e-28 97.5 0.2 1.9 3 0 0 3 3 3 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EDK38598.2 - 7.7e-27 93.2 0.1 1.3e-26 92.5 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain RhoGAP PF00620.27 EDK38598.2 - 8.4e-05 22.4 0.1 0.00062 19.6 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain YojJ PF10372.9 EDK38598.2 - 0.0017 18.4 1.2 0.0033 17.5 1.2 1.5 1 0 0 1 1 1 1 Bacterial membrane-spanning protein N-terminus DUF445 PF04286.12 EDK38598.2 - 0.0022 17.8 0.5 0.0025 17.7 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Nramp PF01566.18 EDK38600.2 - 6.4e-91 305.0 15.6 1.9e-55 188.3 3.4 2.1 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein Jagunal PF07086.12 EDK38600.2 - 2.9 7.9 11.9 3.4 7.7 4.3 3.1 3 0 0 3 3 3 0 Jagunal, ER re-organisation during oogenesis Asp PF00026.23 EDK38602.2 - 3.8e-58 197.4 0.2 4.9e-58 197.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK38602.2 - 1.7e-07 31.7 0.1 6.9e-06 26.4 0.1 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDK38602.2 - 0.00014 22.4 0.0 0.038 14.6 0.0 3.5 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EDK38602.2 - 0.0083 16.7 0.0 1 10.0 0.0 2.7 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDK38602.2 - 0.079 12.7 0.0 1.8 8.3 0.0 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Asp PF00026.23 EDK38603.2 - 3.7e-69 233.6 6.8 4.3e-69 233.3 6.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK38603.2 - 3.7e-08 33.8 1.6 3.9e-06 27.2 1.6 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDK38603.2 - 0.0007 19.4 0.0 0.0096 15.7 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal AA_permease_2 PF13520.6 EDK38604.2 - 2.2e-46 158.6 46.8 2.7e-46 158.3 46.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK38604.2 - 6.4e-24 84.4 40.1 8.6e-24 84.0 40.1 1.0 1 0 0 1 1 1 1 Amino acid permease SfLAP PF11139.8 EDK38604.2 - 0.79 9.1 14.7 0.29 10.5 1.5 3.1 3 2 0 3 3 3 0 Sap, sulfolipid-1-addressing protein YoqO PF14037.6 EDK38604.2 - 3.4 8.2 8.2 0.69 10.5 0.5 3.0 3 0 0 3 3 3 0 YoqO-like protein MatE PF01554.18 EDK38605.2 - 2.1e-61 206.3 31.8 1.1e-40 139.0 7.7 2.9 4 0 0 4 4 4 2 MatE Glyco_hydro_76 PF03663.14 EDK38606.2 - 9.2e-144 479.5 16.6 1.1e-143 479.2 16.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Hydrolase_like PF13242.6 EDK38607.2 - 1.3e-08 34.8 0.0 3.1e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDK38607.2 - 6.7e-08 33.1 0.0 9.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDK38607.2 - 2.2e-06 27.9 0.0 4.5e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Fungal_trans_2 PF11951.8 EDK38608.2 - 1.3e-49 169.0 0.2 3.4e-49 167.7 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK38608.2 - 4.1e-07 30.0 10.8 7.8e-07 29.1 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Adap_comp_sub PF00928.21 EDK38609.2 - 5.5e-56 189.9 2.4 9.9e-56 189.0 2.4 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Coilin_N PF15862.5 EDK38609.2 - 0.01 15.6 2.3 0.01 15.6 2.3 2.0 2 0 0 2 2 2 0 Coilin N-terminus CHAT PF12770.7 EDK38609.2 - 0.098 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 CHAT domain Pterin_4a PF01329.19 EDK38610.2 - 2.1e-23 82.3 1.2 3e-23 81.8 0.6 1.6 1 1 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase DUF3822 PF12864.7 EDK38610.2 - 0.0031 16.7 0.5 0.0078 15.4 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3822) DUF3510 PF12022.8 EDK38610.2 - 0.18 12.2 4.0 0.63 10.4 4.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) HA2 PF04408.23 EDK38613.2 - 4.2e-15 56.0 0.0 4.2e-15 56.0 0.0 3.3 2 1 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK38613.2 - 1.4e-11 44.7 0.0 3e-10 40.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDK38613.2 - 4.3e-09 36.4 0.0 9e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK38613.2 - 3.4e-06 27.4 0.0 8.6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDK38613.2 - 0.0084 15.2 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EDK38613.2 - 0.0087 16.4 0.1 0.029 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDK38613.2 - 0.017 14.5 0.0 0.039 13.3 0.0 1.6 1 0 0 1 1 1 0 KaiC Flavi_DEAD PF07652.14 EDK38613.2 - 0.039 13.9 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 EDK38613.2 - 0.093 12.2 0.0 0.25 10.8 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein Raftlin PF15250.6 EDK38613.2 - 4.5 5.9 12.2 7.3 5.2 12.2 1.4 1 0 0 1 1 1 0 Raftlin Synaptobrevin PF00957.21 EDK38614.2 - 1.4e-24 85.7 1.0 2.2e-24 85.1 1.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Herpes_UL6 PF01763.16 EDK38614.2 - 0.0032 16.1 0.3 0.0039 15.8 0.3 1.1 1 0 0 1 1 1 1 Herpesvirus UL6 like CBFD_NFYB_HMF PF00808.23 EDK38615.2 - 1.9e-07 31.3 0.1 4.2e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EDK38615.2 - 8.4e-05 22.7 0.2 0.00013 22.0 0.2 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EDK38615.2 - 0.00052 20.4 0.1 0.00052 20.4 0.1 2.5 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.14 EDK38615.2 - 0.0065 16.5 0.1 0.016 15.3 0.1 1.6 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Cwf_Cwc_15 PF04889.12 EDK38615.2 - 0.14 11.8 21.7 0.19 11.4 21.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Smg8_Smg9 PF10220.9 EDK38615.2 - 0.71 8.1 11.8 0.94 7.7 11.8 1.1 1 0 0 1 1 1 0 Smg8_Smg9 BUD22 PF09073.10 EDK38615.2 - 1.5 8.1 28.7 2 7.7 28.7 1.1 1 0 0 1 1 1 0 BUD22 Raftlin PF15250.6 EDK38615.2 - 3.4 6.3 10.2 4.2 6.0 10.2 1.1 1 0 0 1 1 1 0 Raftlin Sec62 PF03839.16 EDK38615.2 - 8.3 5.8 9.5 13 5.2 9.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 FAM60A PF15396.6 EDK38615.2 - 9.8 6.1 10.2 16 5.4 10.2 1.4 1 0 0 1 1 1 0 Protein Family FAM60A MOZ_SAS PF01853.18 EDK38616.2 - 1.2e-49 168.4 0.0 2e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDK38616.2 - 8.3e-10 38.1 7.3 0.00019 21.0 4.4 2.8 2 0 0 2 2 2 2 MYST family zinc finger domain SNF2_N PF00176.23 EDK38617.2 - 2e-72 243.8 0.1 3e-72 243.2 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK38617.2 - 3.9e-14 52.9 0.1 1e-12 48.3 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HIRAN PF08797.11 EDK38617.2 - 3.4e-12 46.1 0.0 8e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.6 EDK38617.2 - 2.2e-07 31.1 8.8 4.9e-07 30.0 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDK38617.2 - 4.9e-07 29.5 10.1 9.5e-07 28.6 10.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK38617.2 - 1.1e-06 28.5 8.3 2e-06 27.6 8.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDK38617.2 - 2.4e-06 27.5 7.9 5.3e-06 26.4 7.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDK38617.2 - 1.2e-05 25.1 7.2 2.1e-05 24.3 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDK38617.2 - 0.0053 16.5 4.7 0.013 15.2 4.7 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDK38617.2 - 0.0067 16.3 8.9 0.016 15.1 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK38617.2 - 0.012 15.4 8.6 0.025 14.4 8.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDK38617.2 - 0.015 15.5 8.6 0.037 14.2 8.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDK38617.2 - 0.19 12.1 4.9 0.55 10.6 4.9 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDK38617.2 - 0.29 11.2 3.0 0.59 10.2 3.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EDK38617.2 - 0.53 10.1 4.6 1.1 9.1 4.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DAHP_synth_1 PF00793.20 EDK38618.1 - 1.4e-97 325.9 0.0 1.6e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family UCH PF00443.29 EDK38619.2 - 1e-41 143.2 0.2 1.7e-41 142.4 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EDK38619.2 - 9.8e-23 79.7 3.9 2.2e-20 72.2 0.8 2.8 2 0 0 2 2 2 2 Variant UBP zinc finger zf-UBP PF02148.19 EDK38619.2 - 1.4e-20 73.4 4.1 1.4e-20 73.4 4.1 3.5 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EDK38619.2 - 4e-17 61.7 0.0 2.7e-08 33.6 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EDK38619.2 - 4.5e-16 59.3 5.7 1.4e-15 57.7 1.4 3.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Glyco_hydro_18 PF00704.28 EDK38620.2 - 7.5e-67 226.3 0.3 8.5e-67 226.1 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.11 EDK38621.1 - 4.1e-67 226.2 0.2 4.9e-67 225.9 0.2 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PIP5K PF01504.18 EDK38622.2 - 5.6e-43 147.1 2.8 2.1e-32 112.5 3.3 3.0 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EDK38622.2 - 1.6e-22 79.8 0.1 2.9e-22 79.0 0.1 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EDK38622.2 - 5.5e-16 58.5 10.2 5.5e-16 58.5 10.2 2.3 2 0 0 2 2 2 1 FYVE zinc finger SNX17_FERM_C PF18116.1 EDK38622.2 - 0.11 12.6 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain C1_4 PF07975.12 EDK38622.2 - 1.4 9.2 9.0 5.9 7.2 9.0 2.1 1 0 0 1 1 1 0 TFIIH C1-like domain SUR7 PF06687.12 EDK38623.2 - 1e-16 61.2 20.3 1.6e-16 60.6 20.3 1.3 1 0 0 1 1 1 1 SUR7/PalI family SNARE PF05739.19 EDK38625.2 - 4.7e-12 45.7 3.1 1.3e-11 44.3 0.3 2.6 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 EDK38625.2 - 0.00076 19.2 7.0 0.0014 18.3 7.0 1.4 1 0 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 EDK38625.2 - 0.074 12.9 1.0 0.13 12.1 1.0 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMPIT PF07851.13 EDK38625.2 - 0.45 9.7 6.3 0.17 11.1 3.3 1.7 1 1 1 2 2 2 0 TMPIT-like protein Sec20 PF03908.13 EDK38625.2 - 0.56 10.2 6.4 0.21 11.5 0.9 2.8 1 1 1 2 2 2 0 Sec20 Cauli_DNA-bind PF03310.13 EDK38625.2 - 1.6 8.8 5.4 0.87 9.7 0.2 2.6 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein Exonuc_VII_L PF02601.15 EDK38625.2 - 3.9 7.0 7.3 5.4 6.5 7.1 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit Arrestin_C PF02752.22 EDK38626.2 - 5.3e-17 62.5 0.0 1.1e-16 61.6 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDK38626.2 - 1.2e-09 38.4 0.0 1.3e-07 31.7 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EDK38626.2 - 0.026 14.2 0.0 0.066 12.9 0.0 1.6 2 0 0 2 2 2 0 Arrestin_N terminal like DUF4971 PF16341.5 EDK38627.2 - 0.066 13.0 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4971) LRR_6 PF13516.6 EDK38627.2 - 0.072 13.2 1.5 66 4.0 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich repeat DUF2625 PF10946.8 EDK38628.2 - 0.091 11.8 0.2 0.15 11.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 NatB_MDM20 PF09797.9 EDK38629.2 - 1.4e-69 234.9 18.3 1.4e-69 234.9 18.3 2.4 2 1 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 EDK38629.2 - 0.0088 16.5 6.2 0.05 14.1 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDK38629.2 - 0.037 14.7 0.0 0.74 10.5 0.0 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDK38629.2 - 0.045 14.6 1.0 1.2 10.1 0.0 3.8 3 1 2 5 5 5 0 Tetratricopeptide repeat L_protein_N PF15518.6 EDK38629.2 - 0.053 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 L protein N-terminus TPR_6 PF13174.6 EDK38629.2 - 0.055 14.1 0.5 6.4 7.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK38629.2 - 0.085 13.1 17.8 0.34 11.2 0.1 4.7 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 SAUGI PF06106.11 EDK38629.2 - 0.61 10.6 5.5 0.59 10.7 0.2 3.3 3 1 0 3 3 3 0 S. aureus uracil DNA glycosylase inhibitor E1-E2_ATPase PF00122.20 EDK38630.2 - 2e-34 118.7 23.1 8.6e-30 103.6 0.3 3.7 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDK38630.2 - 2.5e-24 86.0 0.9 2.5e-24 86.0 0.9 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EDK38630.2 - 2.3e-22 78.9 0.1 4.7e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDK38630.2 - 2.3e-19 70.5 0.0 4.2e-18 66.4 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDK38630.2 - 4.4e-10 39.1 0.0 1.1e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDK38630.2 - 8.9e-05 22.3 0.7 0.00073 19.4 0.7 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase His_Phos_1 PF00300.22 EDK38631.1 - 3.7e-40 137.7 0.0 5.5e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pantoate_transf PF02548.15 EDK38632.1 - 4.2e-103 344.2 0.2 4.9e-103 344.0 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EDK38632.1 - 5e-09 36.0 0.2 9.4e-09 35.1 0.2 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Glyoxalase PF00903.25 EDK38633.2 - 6.4e-37 126.6 0.2 1.1e-17 64.5 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDK38633.2 - 3.8e-10 40.0 0.1 0.00062 20.0 0.0 3.9 1 1 3 4 4 4 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EDK38633.2 - 0.00094 19.1 0.5 3.2 7.7 0.0 3.3 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EDK38633.2 - 0.0025 18.6 0.0 3.9 8.3 0.0 2.7 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EDK38633.2 - 0.042 14.0 0.0 3.9 7.5 0.0 2.7 2 1 0 2 2 2 0 Glyoxalase-like domain CppA_N PF14506.6 EDK38633.2 - 0.044 13.9 0.0 2.9 8.0 0.0 2.5 3 0 0 3 3 3 0 CppA N-terminal UCH PF00443.29 EDK38634.2 - 1.5e-46 159.0 1.3 1.9e-46 158.7 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK38634.2 - 1.2e-10 41.6 8.1 1.3e-06 28.3 1.2 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EDK38634.2 - 1.8e-09 37.2 0.2 7.6e-09 35.2 0.2 2.1 1 0 0 1 1 1 1 Ubiquitin family TBK1_ULD PF18396.1 EDK38634.2 - 0.028 14.3 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain DUF3322 PF11795.8 EDK38634.2 - 0.056 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Pex19 PF04614.12 EDK38634.2 - 0.16 11.7 4.9 2.5 7.8 0.9 2.3 2 0 0 2 2 2 0 Pex19 protein family Lactamase_B_2 PF12706.7 EDK38635.2 - 8.4e-25 87.5 0.0 1.3e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EDK38635.2 - 6.4e-11 42.4 0.0 1.2e-10 41.5 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ABC_tran PF00005.27 EDK38636.2 - 3.4e-44 150.7 4.6 3e-22 79.6 0.1 3.4 3 1 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDK38636.2 - 5.7e-22 77.5 4.8 5.7e-22 77.5 4.8 4.0 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.6 EDK38636.2 - 2.1e-15 57.4 14.9 7.1e-05 22.8 0.0 5.3 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDK38636.2 - 2.3e-09 37.0 3.8 0.0011 18.5 0.8 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EDK38636.2 - 3e-06 27.6 0.2 0.049 13.9 0.2 3.0 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDK38636.2 - 8.2e-06 25.8 0.1 0.058 13.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDK38636.2 - 9.1e-06 25.3 0.5 0.13 12.0 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK38636.2 - 9.5e-06 26.1 0.8 0.0096 16.3 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_18 PF13238.6 EDK38636.2 - 2.5e-05 24.8 6.4 0.026 15.0 0.1 4.2 5 0 0 5 5 4 2 AAA domain AAA PF00004.29 EDK38636.2 - 4.9e-05 23.8 1.4 0.37 11.2 0.0 4.3 4 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDK38636.2 - 7.7e-05 22.5 0.1 0.12 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDK38636.2 - 8.8e-05 22.3 0.0 0.22 11.2 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 EDK38636.2 - 0.00017 22.2 32.0 0.12 12.9 0.0 5.2 5 0 0 5 5 5 2 AAA domain AAA_22 PF13401.6 EDK38636.2 - 0.00032 21.0 4.6 0.53 10.6 0.5 3.7 3 2 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EDK38636.2 - 0.00032 20.9 5.1 0.15 12.2 0.0 3.3 4 1 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.23 EDK38636.2 - 0.00076 19.6 2.8 0.099 12.7 0.2 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 EDK38636.2 - 0.001 19.0 0.8 0.81 9.6 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 EDK38636.2 - 0.0022 17.5 2.2 0.83 9.1 0.1 2.9 3 0 0 3 3 3 2 P-loop containing dynein motor region RNA_helicase PF00910.22 EDK38636.2 - 0.0031 17.9 0.1 4.4 7.7 0.0 3.0 2 0 0 2 2 2 1 RNA helicase PduV-EutP PF10662.9 EDK38636.2 - 0.0037 17.0 0.4 2.8 7.7 0.0 2.7 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 EDK38636.2 - 0.0061 16.6 0.1 1.1 9.3 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDK38636.2 - 0.0076 16.0 29.1 0.16 11.6 0.0 4.5 4 1 0 4 4 4 2 AAA ATPase domain ATP-synt_ab PF00006.25 EDK38636.2 - 0.011 15.4 0.0 0.19 11.3 0.0 2.5 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Roc PF08477.13 EDK38636.2 - 0.015 15.5 0.1 5 7.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TIP49 PF06068.13 EDK38636.2 - 0.02 14.1 0.0 0.097 11.9 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain MobB PF03205.14 EDK38636.2 - 0.027 14.4 0.0 0.69 9.8 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.23 EDK38636.2 - 0.027 14.5 0.3 0.027 14.5 0.3 4.1 3 1 0 4 4 4 0 Dynamin family TsaE PF02367.17 EDK38636.2 - 0.029 14.4 0.0 4.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 EDK38636.2 - 0.038 13.0 2.6 0.54 9.2 0.0 3.4 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EDK38636.2 - 0.065 12.8 0.0 7.4 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EDK38636.2 - 0.068 13.5 0.5 3.1 8.1 0.0 3.2 4 0 0 4 4 3 0 AAA domain Pox_A32 PF04665.12 EDK38636.2 - 0.095 12.1 3.0 1.2 8.6 0.1 3.2 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_5 PF07728.14 EDK38636.2 - 0.099 12.6 0.1 3.1 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 EDK38636.2 - 0.34 10.5 2.6 12 5.5 0.2 3.4 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain Vps39_2 PF10367.9 EDK38636.2 - 2 8.9 4.3 1.5 9.3 1.8 2.1 2 0 0 2 2 1 0 Vacuolar sorting protein 39 domain 2 Aldedh PF00171.22 EDK38637.2 - 1.5e-78 264.4 0.0 1.9e-78 264.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDK38637.2 - 0.00011 21.4 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF3764 PF12594.8 EDK38637.2 - 0.017 15.1 0.1 0.037 14.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) Cir_Bir_Yir PF06022.11 EDK38637.2 - 0.038 13.5 0.1 0.088 12.3 0.1 1.5 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir Aldo_ket_red PF00248.21 EDK38638.2 - 3e-43 148.1 1.2 6.9e-41 140.4 1.2 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family SnoaL PF07366.12 EDK38639.1 - 1.4e-26 92.8 0.0 1.7e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EDK38639.1 - 2.2e-17 63.5 0.0 2.7e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain Flavoprotein PF02441.19 EDK38640.2 - 1.8e-33 115.5 0.0 8.3e-33 113.4 0.0 1.9 1 1 0 1 1 1 1 Flavoprotein Peptidase_S9 PF00326.21 EDK38641.2 - 0.0013 18.2 0.1 0.043 13.3 0.0 2.6 2 1 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.20 EDK38641.2 - 0.0023 17.6 0.0 0.0059 16.3 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Imm39 PF15568.6 EDK38641.2 - 0.005 17.0 0.0 0.35 11.0 0.0 2.4 2 1 0 2 2 2 1 Immunity protein 39 Abhydrolase_2 PF02230.16 EDK38641.2 - 0.012 15.5 0.0 0.033 14.0 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EDK38641.2 - 0.013 14.8 0.0 0.069 12.4 0.0 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DLH PF01738.18 EDK38641.2 - 0.046 13.3 0.0 7.3 6.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EDK38641.2 - 0.086 12.5 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 alpha/beta hydrolase fold FSH1 PF03959.13 EDK38641.2 - 0.12 12.0 0.0 0.33 10.6 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) WD40 PF00400.32 EDK38642.2 - 3.3e-09 37.2 0.1 0.012 16.5 0.0 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38642.2 - 1.1e-05 25.6 0.0 1.3 9.3 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK38642.2 - 0.0041 16.1 0.3 0.28 10.1 0.0 2.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Serglycin PF04360.12 EDK38642.2 - 0.064 13.2 1.7 0.17 11.8 1.7 1.7 1 0 0 1 1 1 0 Serglycin CSRNP_N PF16019.5 EDK38642.2 - 0.067 13.1 1.1 0.12 12.3 1.1 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PBP1_TM PF14812.6 EDK38642.2 - 0.71 10.3 5.2 1.5 9.2 5.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNB PF00773.19 EDK38643.2 - 2.1e-100 336.2 0.0 3e-100 335.7 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EDK38643.2 - 2.9e-48 163.3 0.1 6e-48 162.3 0.1 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EDK38643.2 - 6.7e-29 99.7 2.2 6.7e-29 99.7 2.2 2.1 2 0 0 2 2 2 1 S1 domain OB_Dis3 PF17849.1 EDK38643.2 - 5.2e-18 64.8 0.0 1.3e-17 63.6 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EDK38643.2 - 7.2e-17 61.9 0.1 1.9e-16 60.5 0.1 1.8 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EDK38643.2 - 3.7e-06 27.0 0.0 0.00014 21.9 0.0 2.8 2 0 0 2 2 2 1 Cold shock domain Dis3l2_C_term PF17877.1 EDK38643.2 - 0.05 13.9 0.4 0.16 12.3 0.4 1.8 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal OB_RNB PF08206.11 EDK38643.2 - 0.11 12.2 0.2 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease B OB domain DHBP_synthase PF00926.19 EDK38644.2 - 1.5e-85 285.6 0.2 1.7e-85 285.4 0.2 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase tRNA-synt_1b PF00579.25 EDK38645.1 - 1.8e-17 63.6 0.0 1.8e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Ribosomal_L27e PF01777.18 EDK38646.1 - 2.2e-20 72.8 1.3 2.4e-20 72.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal L27e protein family MFS_1 PF07690.16 EDK38647.1 - 5.8e-28 97.8 27.3 1.5e-27 96.5 23.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK38647.1 - 0.0027 16.2 2.1 0.004 15.6 2.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Siah-Interact_N PF09032.11 EDK38647.1 - 4.2 7.7 6.1 5.4 7.4 0.5 2.4 1 1 1 2 2 2 0 Siah interacting protein, N terminal Pkinase PF00069.25 EDK38648.2 - 5.7e-66 222.6 0.2 9e-66 221.9 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38648.2 - 2.1e-33 115.7 0.0 2.9e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK38648.2 - 7.9e-06 25.4 0.0 7.1e-05 22.3 0.0 2.1 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDK38648.2 - 0.00029 20.6 1.5 0.21 11.2 0.1 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDK38648.2 - 0.00042 19.7 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDK38648.2 - 0.001 18.1 0.5 0.0028 16.7 0.5 1.7 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDK38648.2 - 0.044 12.6 1.9 0.072 11.8 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EDK38648.2 - 0.089 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CRIM PF16978.5 EDK38649.2 - 2.8e-30 105.3 0.0 2.8e-30 105.3 0.0 2.4 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EDK38649.2 - 4.9e-16 59.0 1.2 6.1e-14 52.2 1.2 2.8 1 1 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RBD PF02196.15 EDK38649.2 - 0.048 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Raf-like Ras-binding domain RNase_T PF00929.24 EDK38650.2 - 4.8e-13 50.0 0.0 1.4e-12 48.5 0.0 1.8 2 0 0 2 2 2 1 Exonuclease TALPID3 PF15324.6 EDK38650.2 - 0.64 7.6 9.9 0.84 7.2 9.9 1.1 1 0 0 1 1 1 0 Hedgehog signalling target RasGAP PF00616.19 EDK38653.2 - 6e-22 78.4 9.2 2.1e-11 43.9 0.6 3.4 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase ATP19 PF11022.8 EDK38654.1 - 3e-23 82.0 0.0 3.3e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Brix PF04427.18 EDK38655.2 - 9.9e-41 140.0 0.9 1.5e-40 139.3 0.9 1.3 1 0 0 1 1 1 1 Brix domain Rhomboid PF01694.22 EDK38656.2 - 1.1e-29 103.4 12.6 2.7e-29 102.1 11.0 2.3 2 0 0 2 2 2 1 Rhomboid family DUF2177 PF09945.9 EDK38656.2 - 3.8 7.6 6.8 0.32 11.1 0.9 2.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2177) Ribosomal_L50 PF10501.9 EDK38657.1 - 3.4e-35 120.5 0.9 6.6e-35 119.6 0.9 1.5 1 0 0 1 1 1 1 Ribosomal subunit 39S DUF285 PF03382.14 EDK38657.1 - 0.11 12.3 0.5 0.18 11.6 0.5 1.3 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 CBS PF00571.28 EDK38658.2 - 6.4e-33 113.0 7.3 3.1e-09 37.1 0.0 5.0 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 EDK38658.2 - 1.5e-07 31.3 0.3 3e-07 30.3 0.3 1.6 1 0 0 1 1 1 1 PB1 domain Prenyltransf PF01255.19 EDK38659.1 - 1.7e-71 240.3 0.1 2.2e-71 240.0 0.1 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Vma12 PF11712.8 EDK38660.1 - 2.9e-41 140.8 0.4 4e-41 140.4 0.4 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3878 PF12994.7 EDK38660.1 - 0.0028 17.2 0.1 0.0037 16.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3878) DUF4149 PF13664.6 EDK38660.1 - 0.067 13.5 0.0 0.099 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) tRNA_SAD PF07973.14 EDK38661.2 - 5.4e-11 42.4 0.1 1.4e-10 41.1 0.1 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 EDK38661.2 - 2.5e-07 29.6 0.0 4.3e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) DUF4824 PF16106.5 EDK38661.2 - 0.099 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) Ribosomal_S9 PF00380.19 EDK38662.2 - 1.8e-43 147.9 0.5 3.2e-43 147.1 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Myb_DNA-binding PF00249.31 EDK38663.2 - 4.5e-11 42.7 0.0 0.00032 20.8 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EDK38663.2 - 6.8e-05 22.7 0.0 0.00033 20.5 0.0 2.2 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EDK38663.2 - 0.01 16.1 0.5 1.1 9.6 0.1 3.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain AAA_16 PF13191.6 EDK38664.2 - 2.4e-11 44.3 0.3 8.4e-11 42.5 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDK38664.2 - 2.9e-09 37.3 0.1 6.5e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EDK38664.2 - 1.2e-08 35.4 0.0 2.7e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EDK38664.2 - 0.00033 21.0 0.0 0.00067 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDK38664.2 - 0.00058 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EDK38664.2 - 0.0023 17.9 0.1 0.005 16.8 0.1 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Cdc6_C PF09079.11 EDK38664.2 - 0.0029 17.6 0.0 0.008 16.1 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain TniB PF05621.11 EDK38664.2 - 0.0067 15.9 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein Myosin_head PF00063.21 EDK38664.2 - 0.0077 14.5 0.1 0.2 9.9 0.0 2.1 2 0 0 2 2 2 1 Myosin head (motor domain) NTPase_1 PF03266.15 EDK38664.2 - 0.017 15.0 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 EDK38664.2 - 0.055 13.0 0.0 0.23 11.0 0.1 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EDK38664.2 - 0.055 13.4 0.1 0.14 12.0 0.1 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EDK38664.2 - 0.059 13.8 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EDK38664.2 - 0.068 12.4 0.0 0.18 11.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 EDK38664.2 - 0.071 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 EDK38664.2 - 0.076 12.2 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ResIII PF04851.15 EDK38664.2 - 0.11 12.5 0.1 0.38 10.7 0.1 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK38664.2 - 0.62 9.8 3.1 5.6 6.7 3.1 2.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase CENP-S PF15630.6 EDK38665.2 - 1.1e-26 93.0 0.0 1.3e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDK38665.2 - 1.1e-06 28.7 0.0 1.3e-06 28.4 0.0 1.3 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EDK38665.2 - 0.1 12.6 0.0 0.17 11.9 0.0 1.5 1 1 0 1 1 1 0 Bromodomain associated DUF3337 PF11816.8 EDK38666.2 - 5.4e-43 146.8 0.1 1.2e-42 145.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EDK38666.2 - 4.5e-09 36.8 15.5 0.003 18.3 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38666.2 - 0.011 16.1 0.0 2 8.8 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_Rpb5_C PF01191.19 EDK38667.1 - 2.2e-31 107.5 0.2 3.4e-31 106.9 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EDK38667.1 - 1.1e-11 45.2 0.0 1.8e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain SH3_2 PF07653.17 EDK38667.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain RibD_C PF01872.17 EDK38668.2 - 1.7e-29 103.1 0.0 2.2e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 RibD C-terminal domain MFAP1 PF06991.11 EDK38669.2 - 8.5e-08 32.3 12.0 6.1e-07 29.5 11.2 2.0 1 1 1 2 2 2 2 Microfibril-associated/Pre-mRNA processing AF-4 PF05110.13 EDK38669.2 - 0.0027 15.9 6.6 0.0029 15.8 6.6 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein RAP1 PF07218.11 EDK38669.2 - 0.11 10.8 6.2 0.12 10.6 6.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ELO PF01151.18 EDK38670.1 - 1.9e-59 201.2 16.2 2.4e-59 200.9 16.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PfkB PF00294.24 EDK38671.2 - 1.1e-56 192.4 0.3 1.3e-56 192.1 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDK38671.2 - 1.6e-05 24.5 0.3 3e-05 23.5 0.3 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PCI PF01399.27 EDK38672.2 - 4.4e-09 36.8 0.2 2.5e-08 34.4 0.2 2.5 1 0 0 1 1 1 1 PCI domain DUF1947 PF09183.10 EDK38672.2 - 3 8.2 9.3 0.19 12.1 1.7 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) BCIP PF13862.6 EDK38673.1 - 3.2e-68 229.6 5.4 4e-68 229.3 5.4 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein WD40 PF00400.32 EDK38674.2 - 2.4e-19 69.3 12.9 0.00013 22.7 0.1 5.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38674.2 - 3.7e-07 30.3 0.1 0.23 11.8 0.0 3.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain UCH PF00443.29 EDK38675.2 - 1.2e-13 51.2 0.0 2.8e-13 50.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK38675.2 - 1.6e-11 44.4 0.0 1.7e-05 24.6 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase BAR PF03114.18 EDK38676.2 - 8.8e-44 149.9 10.3 1e-43 149.7 10.3 1.1 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.13 EDK38676.2 - 0.00026 20.6 8.1 0.00049 19.7 8.1 1.5 1 1 0 1 1 1 1 Arfaptin-like domain BAR_3 PF16746.5 EDK38676.2 - 0.015 15.0 7.7 0.021 14.5 7.7 1.2 1 0 0 1 1 1 0 BAR domain of APPL family DUF3338 PF11819.8 EDK38676.2 - 0.022 14.7 0.4 0.022 14.7 0.4 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3338) Phasin_2 PF09361.10 EDK38676.2 - 0.075 13.3 2.6 4.2 7.7 0.8 2.7 2 1 0 2 2 2 0 Phasin protein BBE PF08031.12 EDK38676.2 - 0.084 13.0 0.2 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 Berberine and berberine like DUF4407 PF14362.6 EDK38676.2 - 0.29 10.4 2.4 0.38 10.1 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dict-STAT-coil PF09267.10 EDK38676.2 - 0.46 10.9 2.9 2.1 8.7 0.1 2.9 2 1 2 4 4 4 0 Dictyostelium STAT, coiled coil BLYB PF05289.11 EDK38676.2 - 1.3 9.3 4.6 1.6 8.9 0.3 2.4 2 1 1 3 3 3 0 Borrelia hemolysin accessory protein GST_C PF00043.25 EDK38676.2 - 5.4 7.3 7.2 4.8 7.5 0.1 3.4 2 2 1 3 3 3 0 Glutathione S-transferase, C-terminal domain AMPKBI PF04739.15 EDK38677.2 - 9.4e-28 96.3 5.6 5.2e-27 93.9 5.6 2.4 1 1 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EDK38677.2 - 2.2e-17 63.0 0.2 4.4e-17 62.1 0.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Glyco_hydro_32N PF00251.20 EDK38679.2 - 5.2e-86 289.0 6.2 6.9e-86 288.6 6.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EDK38679.2 - 8.4e-20 71.4 0.4 1.5e-19 70.5 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal AAA PF00004.29 EDK38680.2 - 2.9e-52 176.6 0.1 5.3e-39 133.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK38680.2 - 2.8e-10 39.8 0.1 9.8e-10 38.1 0.0 1.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 EDK38680.2 - 5.6e-09 36.4 1.1 0.00035 20.9 0.1 3.9 3 2 0 4 4 3 2 AAA domain AAA_2 PF07724.14 EDK38680.2 - 4.1e-08 33.5 0.1 7.8e-06 26.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDK38680.2 - 4.7e-08 33.6 0.0 0.0077 16.6 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain RuvB_N PF05496.12 EDK38680.2 - 5.6e-07 29.4 0.1 0.028 14.2 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDK38680.2 - 7.9e-07 28.6 0.0 0.02 14.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 EDK38680.2 - 1.2e-06 28.1 0.2 0.0046 16.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDK38680.2 - 1.5e-06 28.8 0.1 0.013 16.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EDK38680.2 - 2e-06 27.9 0.2 0.0015 18.6 0.1 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK38680.2 - 3.1e-06 27.4 0.0 0.093 12.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDK38680.2 - 1.3e-05 25.5 0.0 0.033 14.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 EDK38680.2 - 1.7e-05 24.6 0.0 0.01 15.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDK38680.2 - 1.8e-05 24.2 0.2 0.042 13.1 0.1 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) CDC48_N PF02359.18 EDK38680.2 - 2.5e-05 24.4 0.0 0.00011 22.3 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_7 PF12775.7 EDK38680.2 - 2.7e-05 23.7 0.4 0.028 13.9 0.0 3.0 3 0 0 3 3 3 1 P-loop containing dynein motor region CDC48_2 PF02933.17 EDK38680.2 - 3.5e-05 23.5 0.9 0.00068 19.4 0.2 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 NB-ARC PF00931.22 EDK38680.2 - 0.00014 21.1 0.2 1.5 7.9 0.0 3.1 3 0 0 3 3 3 2 NB-ARC domain IstB_IS21 PF01695.17 EDK38680.2 - 0.00018 21.3 0.0 0.081 12.7 0.0 2.7 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 EDK38680.2 - 0.00021 21.1 0.0 0.054 13.4 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDK38680.2 - 0.00029 21.1 0.0 0.79 9.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EDK38680.2 - 0.00042 20.3 0.0 0.063 13.3 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EDK38680.2 - 0.00059 19.9 0.0 0.67 9.9 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 EDK38680.2 - 0.00077 19.1 1.4 2 7.9 0.1 3.1 2 1 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EDK38680.2 - 0.00082 19.1 0.0 0.65 9.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.27 EDK38680.2 - 0.0018 18.8 0.2 0.095 13.2 0.1 2.6 2 0 0 2 2 2 1 ABC transporter Parvo_NS1 PF01057.17 EDK38680.2 - 0.0022 17.1 0.0 0.75 8.8 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 PhoH PF02562.16 EDK38680.2 - 0.0025 17.3 0.6 2 7.8 0.0 3.1 3 0 0 3 3 3 1 PhoH-like protein AAA_17 PF13207.6 EDK38680.2 - 0.0028 18.1 0.0 1.5 9.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 EDK38680.2 - 0.0031 16.9 0.3 4.2 6.7 0.1 4.0 4 1 0 4 4 2 0 Bacterial TniB protein AAA_11 PF13086.6 EDK38680.2 - 0.0035 17.2 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDK38680.2 - 0.004 17.2 0.0 0.14 12.2 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EDK38680.2 - 0.0057 17.0 0.0 0.74 10.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EDK38680.2 - 0.0092 15.9 0.8 4.3 7.2 0.0 2.9 3 0 0 3 3 2 0 NACHT domain AAA_30 PF13604.6 EDK38680.2 - 0.012 15.3 0.0 0.76 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDK38680.2 - 0.016 14.5 0.0 0.49 9.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 EDK38680.2 - 0.016 15.0 0.0 0.73 9.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Vps4_C PF09336.10 EDK38680.2 - 0.016 15.2 0.1 0.063 13.3 0.0 2.0 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain ATPase PF06745.13 EDK38680.2 - 0.019 14.3 1.1 1.6 8.0 0.0 3.1 2 1 2 4 4 4 0 KaiC Torsin PF06309.11 EDK38680.2 - 0.02 15.0 0.0 2.8 8.0 0.0 2.9 3 0 0 3 3 2 0 Torsin KTI12 PF08433.10 EDK38680.2 - 0.022 14.2 1.4 6.7 6.1 0.0 3.2 4 0 0 4 4 4 0 Chromatin associated protein KTI12 SKI PF01202.22 EDK38680.2 - 0.029 14.5 0.1 12 6.0 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase CPT PF07931.12 EDK38680.2 - 0.031 14.1 0.1 0.25 11.2 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Rad17 PF03215.15 EDK38680.2 - 0.051 13.5 0.1 0.58 10.0 0.1 2.7 2 1 1 3 3 3 0 Rad17 P-loop domain Hydin_ADK PF17213.3 EDK38680.2 - 0.052 13.8 2.2 0.17 12.1 0.0 2.8 4 0 0 4 4 2 0 Hydin Adenylate kinase-like domain DEAD PF00270.29 EDK38680.2 - 0.12 12.1 1.3 22 4.8 0.1 3.2 2 2 1 3 3 3 0 DEAD/DEAH box helicase Lipase_bact_N PF12262.8 EDK38680.2 - 0.12 11.7 0.0 8.8 5.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial virulence factor lipase N-terminal ATPase_2 PF01637.18 EDK38680.2 - 0.27 11.1 1.7 17 5.2 0.0 3.1 2 2 1 4 4 4 0 ATPase domain predominantly from Archaea DUF1729 PF08354.10 EDK38681.2 - 0.0065 15.4 0.5 0.0089 15.0 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Spc7 PF08317.11 EDK38681.2 - 0.0074 15.2 4.6 0.01 14.7 4.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein V_ATPase_I PF01496.19 EDK38681.2 - 0.031 12.2 0.7 0.039 11.9 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YrzO PF14142.6 EDK38681.2 - 0.035 14.0 5.1 4.8 7.1 0.1 3.4 1 1 3 4 4 4 0 YrzO-like protein DUF16 PF01519.16 EDK38681.2 - 0.051 14.1 8.5 0.54 10.8 8.5 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 YebO PF13974.6 EDK38681.2 - 0.089 12.9 5.4 0.77 9.9 2.5 2.6 1 1 1 2 2 2 0 YebO-like protein FlgN PF05130.12 EDK38681.2 - 0.093 13.2 9.5 0.57 10.7 2.2 2.2 1 1 1 2 2 2 0 FlgN protein DUF3981 PF13139.6 EDK38681.2 - 0.11 12.9 0.3 0.19 12.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) Fmp27_WPPW PF10359.9 EDK38681.2 - 0.16 10.8 3.1 0.21 10.4 3.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF484 PF04340.12 EDK38681.2 - 0.24 11.0 3.0 0.34 10.6 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF484 SlyX PF04102.12 EDK38681.2 - 0.31 11.7 16.0 0.097 13.3 7.3 2.8 1 1 0 2 2 2 0 SlyX FapA PF03961.13 EDK38681.2 - 0.32 9.6 3.9 0.43 9.1 3.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EDK38681.2 - 0.41 10.7 8.9 0.77 9.8 8.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAT PF03127.14 EDK38681.2 - 0.43 10.9 5.7 0.35 11.2 2.7 2.3 2 1 0 3 3 3 0 GAT domain Fib_alpha PF08702.10 EDK38681.2 - 0.45 10.7 6.4 1 9.6 6.4 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3496 PF12001.8 EDK38681.2 - 0.54 10.7 5.0 1.8 9.0 5.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3496) Nup88 PF10168.9 EDK38681.2 - 1.4 6.6 7.1 2 6.1 7.1 1.1 1 0 0 1 1 1 0 Nuclear pore component TBD PF12845.7 EDK38681.2 - 2.4 8.1 6.9 11 6.0 0.3 3.3 2 1 1 3 3 3 0 TBD domain CorA PF01544.18 EDK38681.2 - 3.7 6.8 8.5 1.7 7.9 6.3 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF148 PF02520.17 EDK38681.2 - 4.8 7.3 8.5 30 4.8 8.5 2.1 1 1 0 1 1 1 0 Domain of unknown function DUF148 KxDL PF10241.9 EDK38681.2 - 5.1 7.5 8.1 22 5.4 2.0 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein MpPF26 PF07666.11 EDK38682.2 - 0.0066 16.6 3.2 0.24 11.5 0.2 2.2 2 0 0 2 2 2 2 M penetrans paralogue family 26 TMEM154 PF15102.6 EDK38682.2 - 0.097 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family AhpC-TSA PF00578.21 EDK38683.1 - 4.5e-33 113.8 0.0 6e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK38683.1 - 3.7e-14 52.7 0.0 4.9e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDK38683.1 - 7.3e-13 48.1 0.3 1.7e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 EDK38683.1 - 0.0059 16.5 0.1 0.015 15.2 0.0 1.7 2 0 0 2 2 2 1 SCO1/SenC HIT PF01230.23 EDK38684.2 - 6.7e-23 81.3 0.1 9.3e-23 80.8 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDK38684.2 - 0.00086 19.8 0.1 0.0014 19.1 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EDK38684.2 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 DUF4391 PF14335.6 EDK38684.2 - 0.15 11.7 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Med6 PF04934.14 EDK38685.2 - 2e-50 170.0 0.5 2.6e-50 169.7 0.5 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Pro_isomerase PF00160.21 EDK38687.1 - 1.6e-44 152.0 0.2 2.1e-44 151.6 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IGR PF09597.10 EDK38688.1 - 1.6e-22 79.3 0.1 2.9e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 IGR protein motif ABC_tran_Xtn PF12848.7 EDK38688.1 - 0.0043 17.1 2.4 0.035 14.1 2.4 2.0 1 1 0 1 1 1 1 ABC transporter CoA_binding PF02629.19 EDK38689.2 - 4.6e-26 91.3 1.2 1.1e-25 90.1 1.2 1.7 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 EDK38689.2 - 1.3e-24 86.8 0.0 2.1e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDK38689.2 - 1e-05 25.4 0.0 1.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EDK38689.2 - 0.00028 21.3 0.1 0.0006 20.3 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain Actin PF00022.19 EDK38690.2 - 3.2e-19 68.8 0.7 1.8e-12 46.6 0.0 4.4 4 1 0 4 4 4 2 Actin Actin_micro PF17003.5 EDK38690.2 - 1.2e-09 37.9 6.2 3.6e-05 23.1 0.1 3.2 3 0 0 3 3 3 2 Putative actin-like family MreB_Mbl PF06723.13 EDK38690.2 - 0.00069 18.5 0.0 0.009 14.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EDK38690.2 - 0.003 18.0 1.0 0.0062 16.9 0.2 2.0 2 1 0 2 2 2 1 Cell division protein FtsA Ribosomal_L20 PF00453.18 EDK38690.2 - 0.059 13.5 2.8 1 9.5 1.3 2.7 3 0 0 3 3 3 0 Ribosomal protein L20 CemA PF03040.14 EDK38690.2 - 0.3 11.0 3.1 0.74 9.7 3.1 1.6 1 0 0 1 1 1 0 CemA family Tim17 PF02466.19 EDK38692.2 - 3e-05 24.3 0.1 0.00011 22.6 0.0 1.8 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family La PF05383.17 EDK38693.2 - 3.8e-18 65.3 0.3 8e-18 64.2 0.1 1.7 2 0 0 2 2 2 1 La domain La_HTH_kDCL PF18177.1 EDK38693.2 - 0.0028 17.9 0.0 0.0074 16.6 0.0 1.7 1 0 0 1 1 1 1 La HTH in kinetoplastid DICER domain HCO3_cotransp PF00955.21 EDK38694.2 - 1.5e-07 30.6 10.0 0.00025 20.0 6.9 2.1 1 1 1 2 2 2 2 HCO3- transporter family HCO3_cotransp PF00955.21 EDK38695.2 - 1.9e-49 168.9 7.3 2.3e-43 148.8 7.8 2.0 1 1 1 2 2 2 2 HCO3- transporter family HCO3_cotransp PF00955.21 EDK38696.2 - 1.4e-22 80.2 0.1 2.4e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 HCO3- transporter family HCO3_cotransp PF00955.21 EDK38697.2 - 6.4e-46 157.2 12.0 1.7e-43 149.2 7.6 2.0 1 1 1 2 2 2 2 HCO3- transporter family Asparaginase_2 PF01112.18 EDK38698.2 - 1.4e-18 67.0 0.7 1.4e-10 40.7 0.0 3.0 2 1 0 2 2 2 2 Asparaginase Ribosomal_L24e PF01246.20 EDK38699.1 - 3e-30 104.3 0.1 3e-30 104.3 0.1 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e Ribosomal_L7Ae PF01248.26 EDK38700.1 - 2.1e-23 81.9 0.0 2.3e-23 81.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DASH_Spc34 PF08657.10 EDK38701.2 - 5e-59 200.2 9.4 3.7e-33 115.4 0.1 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 Takusan PF04822.13 EDK38701.2 - 0.017 15.0 3.8 0.043 13.7 3.8 1.7 1 0 0 1 1 1 0 Takusan OmpH PF03938.14 EDK38701.2 - 0.075 13.4 5.7 0.11 12.9 5.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 EDK38701.2 - 0.22 10.7 2.1 0.32 10.2 2.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein AAA_23 PF13476.6 EDK38701.2 - 0.56 10.7 6.9 1.1 9.7 6.9 1.4 1 1 0 1 1 1 0 AAA domain Peptidase_M22 PF00814.25 EDK38702.1 - 2.2e-85 286.7 0.0 2.6e-85 286.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EDK38702.1 - 0.0052 16.5 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 2 Carbamoyltransferase N-terminus DnaJ PF00226.31 EDK38703.2 - 2.9e-20 72.1 0.1 7.6e-20 70.8 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain DUF4523 PF15023.6 EDK38703.2 - 0.00036 20.4 0.3 0.0012 18.7 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF4523) RRM_1 PF00076.22 EDK38703.2 - 0.0033 17.2 0.0 0.0098 15.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF543 PF04418.12 EDK38704.1 - 1.4e-26 92.2 2.8 1.8e-26 91.9 2.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Voltage_CLC PF00654.20 EDK38705.2 - 1e-80 271.7 21.1 1e-80 271.7 21.1 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel MT-A70 PF05063.14 EDK38706.2 - 5.1e-13 49.3 0.0 7.8e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Iso_dh PF00180.20 EDK38707.1 - 4.3e-73 246.5 0.0 5.1e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase mRNA_triPase PF02940.15 EDK38708.2 - 4.2e-60 203.2 3.9 6.4e-60 202.6 3.9 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain CorC_HlyC PF03471.17 EDK38708.2 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Transporter associated domain Glycos_transf_2 PF00535.26 EDK38709.2 - 3e-25 89.0 0.0 4.1e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDK38709.2 - 1.2e-08 35.2 0.0 1.6e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EDK38709.2 - 0.0034 17.9 0.0 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EDK38709.2 - 0.11 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_transf_7N PF13733.6 EDK38709.2 - 0.19 11.4 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 DUF4372 PF14294.6 EDK38710.2 - 0.23 11.6 1.7 0.57 10.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) Per1 PF04080.13 EDK38711.2 - 4.4e-88 295.3 15.6 5.6e-88 295.0 15.6 1.1 1 0 0 1 1 1 1 Per1-like family DUF4956 PF16316.5 EDK38711.2 - 0.016 14.9 0.5 0.016 14.9 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) ANAPC5 PF12862.7 EDK38711.2 - 0.12 12.4 0.1 6.2 7.0 0.2 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 Colicin_V PF02674.16 EDK38711.2 - 0.18 11.7 3.9 0.27 11.2 0.1 2.4 1 1 1 2 2 2 0 Colicin V production protein HlyIII PF03006.20 EDK38711.2 - 0.28 10.9 17.0 1.1 8.9 17.0 1.9 1 1 0 1 1 1 0 Haemolysin-III related CPSase_C PF18302.1 EDK38712.2 - 0.09 13.2 0.0 0.32 11.5 0.0 2.0 1 0 0 1 1 1 0 Carbamoyl phosphate synthetase C-terminal domain PH_11 PF15413.6 EDK38713.2 - 7.3e-16 58.5 0.2 2.8e-15 56.6 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDK38713.2 - 0.0016 18.9 0.3 0.007 16.9 0.3 2.1 1 1 0 1 1 1 1 PH domain MMM1 PF10296.9 EDK38713.2 - 0.005 15.9 2.4 0.02 14.0 0.0 2.7 2 1 1 3 3 3 1 Maintenance of mitochondrial morphology protein 1 PI3_PI4_kinase PF00454.27 EDK38714.2 - 3.4e-53 181.0 0.1 1e-52 179.4 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EDK38714.2 - 1.1e-20 73.4 1.9 5.4e-20 71.2 0.6 2.9 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 EDK38714.2 - 1.1e-15 57.8 7.1 8.7e-15 54.8 7.7 2.3 2 1 0 2 2 2 1 FAT domain FATC PF02260.20 EDK38714.2 - 2.1e-13 49.8 0.1 4.3e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 FATC domain TPR_12 PF13424.6 EDK38714.2 - 0.082 13.2 0.0 9.1 6.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDK38714.2 - 0.2 12.0 2.7 1.2 9.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PRMT5 PF05185.16 EDK38715.2 - 4.8e-41 140.5 0.0 8.6e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EDK38715.2 - 0.00012 22.0 2.0 0.00022 21.1 2.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 EDK38715.2 - 0.00016 22.3 0.0 0.00057 20.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain CKS PF01111.19 EDK38716.2 - 2.5e-32 110.9 0.1 4.4e-32 110.2 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF2867 PF11066.8 EDK38716.2 - 0.066 13.5 0.0 0.088 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) Cir_N PF10197.9 EDK38717.2 - 6.6e-14 51.8 12.0 6.6e-14 51.8 12.0 2.5 2 1 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 EDK38717.2 - 2.1e-12 47.8 0.5 2.1e-12 47.8 0.5 2.5 2 1 0 2 2 2 1 Pre-mRNA splicing factor Ribosomal_S2 PF00318.20 EDK38717.2 - 1.1 8.5 4.6 1.1 8.4 0.8 2.0 2 0 0 2 2 2 0 Ribosomal protein S2 CTP_transf_1 PF01148.20 EDK38718.1 - 3.7e-30 105.6 16.1 4.7e-30 105.3 16.1 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family DUF2126 PF09899.9 EDK38718.1 - 0.21 9.6 0.1 0.26 9.3 0.1 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) MFS_1 PF07690.16 EDK38719.2 - 4.3e-10 39.0 19.5 4.3e-10 39.0 19.5 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Usp PF00582.26 EDK38720.2 - 0.088 13.3 0.0 0.34 11.4 0.0 2.1 2 1 0 2 2 2 0 Universal stress protein family DUF4927 PF16279.5 EDK38720.2 - 5.9 8.0 14.0 1.1 10.3 2.7 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4927) Mid1 PF12929.7 EDK38721.2 - 6.4e-135 450.6 11.8 7.7e-135 450.4 11.8 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EDK38721.2 - 0.00053 20.6 7.0 0.035 14.7 7.0 2.9 1 1 0 1 1 1 1 Fz domain DUF3873 PF12989.7 EDK38721.2 - 0.41 11.1 3.8 6.8 7.1 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF3873) Rep_fac_C PF08542.11 EDK38722.2 - 1.9e-15 57.0 0.1 8e-15 55.0 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EDK38722.2 - 3.2e-11 43.3 0.4 6e-11 42.4 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EDK38722.2 - 2.3e-07 31.0 0.0 5.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EDK38722.2 - 1.1e-05 25.9 0.1 1.7e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EDK38722.2 - 0.00075 19.3 0.1 0.0012 18.7 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DDE_3 PF13358.6 EDK38722.2 - 0.051 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease L27_1 PF09058.10 EDK38722.2 - 0.064 13.2 0.1 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 L27_1 DEAD PF00270.29 EDK38722.2 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase CUE PF02845.16 EDK38723.2 - 1.6e-10 40.5 2.4 7.1e-06 25.6 0.1 3.6 3 0 0 3 3 3 2 CUE domain Smr PF01713.21 EDK38723.2 - 2.3e-05 24.6 0.0 5.3e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Smr domain DMA PF03474.14 EDK38723.2 - 0.06 13.0 0.0 25 4.6 0.0 3.4 4 0 0 4 4 4 0 DMRTA motif Pkinase PF00069.25 EDK38724.2 - 7.7e-73 245.1 0.0 1.2e-72 244.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38724.2 - 9e-49 166.1 0.0 1.6e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDK38724.2 - 2.3e-20 72.7 0.0 7.6e-20 71.0 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EDK38724.2 - 7.4e-06 25.5 0.0 1.5e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDK38724.2 - 0.00086 18.2 4.4 0.00086 18.2 4.4 2.5 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EDK38724.2 - 0.023 13.7 0.3 0.14 11.1 0.3 2.2 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDK38724.2 - 0.031 14.2 0.0 0.34 10.8 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDK38724.2 - 0.12 11.7 0.1 0.33 10.3 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Hydrolase_like PF13242.6 EDK38725.1 - 2.7e-16 59.4 0.0 5.4e-15 55.2 0.0 2.9 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EDK38725.1 - 1.2e-11 44.6 0.0 2.6e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase adh_short PF00106.25 EDK38727.1 - 1.8e-34 119.0 0.1 2.3e-34 118.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK38727.1 - 3.8e-32 111.7 0.0 4.6e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK38727.1 - 7.6e-12 45.5 0.0 9.3e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK38727.1 - 3e-06 27.3 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK38727.1 - 1.9e-05 24.3 0.1 5e-05 22.9 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDK38727.1 - 0.00023 20.7 0.3 0.0014 18.1 0.3 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase STALD PF18185.1 EDK38727.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family DUF1776 PF08643.10 EDK38727.1 - 0.079 12.3 0.1 0.23 10.8 0.0 1.6 1 1 0 2 2 2 0 Fungal family of unknown function (DUF1776) Glyco_tran_WecB PF03808.13 EDK38727.1 - 0.11 12.5 0.0 5.4 6.9 0.0 2.2 1 1 1 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family UPF0052 PF01933.18 EDK38727.1 - 0.12 11.6 0.1 0.24 10.6 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0052 TrkA_N PF02254.18 EDK38727.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain Fcf1 PF04900.12 EDK38728.1 - 3.9e-36 123.4 0.4 6.4e-36 122.7 0.4 1.3 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EDK38728.1 - 1.2e-14 54.5 0.0 2.2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 EDK38728.1 - 0.036 14.4 0.0 0.065 13.5 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Metallophos PF00149.28 EDK38729.2 - 8e-10 39.6 0.6 1.3e-09 38.9 0.2 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase UBA PF00627.31 EDK38730.2 - 2.3e-08 33.8 0.1 5.7e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.6 EDK38730.2 - 0.00099 18.9 1.5 0.0015 18.3 0.0 2.0 2 0 0 2 2 2 1 UBA-like domain CUE PF02845.16 EDK38730.2 - 0.0052 16.5 0.0 0.016 14.9 0.0 1.9 1 0 0 1 1 1 1 CUE domain tRNA-synt_1d PF00750.19 EDK38731.2 - 1.1e-115 386.4 5.8 1.3e-115 386.1 5.8 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EDK38731.2 - 4.5e-29 101.0 0.0 2.7e-28 98.5 0.0 2.4 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EDK38731.2 - 8.4e-06 26.3 0.0 2.3e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain POT1 PF02765.17 EDK38731.2 - 0.069 13.0 0.3 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Telomeric single stranded DNA binding POT1/CDC13 PINIT PF14324.6 EDK38732.2 - 1.9e-31 109.4 0.0 1.9e-31 109.4 0.0 6.9 3 1 1 4 4 2 1 PINIT domain zf-MIZ PF02891.20 EDK38732.2 - 1.4e-21 76.0 6.6 2.9e-21 75.0 6.6 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 EDK38732.2 - 5.8e-08 32.3 0.5 5.8e-08 32.3 0.5 2.3 2 0 0 2 2 2 1 SAP domain zf-Nse PF11789.8 EDK38732.2 - 2.3e-07 30.5 2.3 5.8e-07 29.2 2.3 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EDK38732.2 - 0.0048 16.7 2.3 0.012 15.5 2.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDK38732.2 - 0.15 12.3 7.1 0.29 11.3 7.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDK38732.2 - 0.27 11.3 5.7 0.65 10.1 5.7 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDK38732.2 - 0.28 11.1 3.1 0.53 10.2 3.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK38732.2 - 0.31 11.4 5.9 0.56 10.6 5.9 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EDK38732.2 - 0.39 10.6 7.4 0.74 9.7 7.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDK38732.2 - 0.82 9.6 6.1 1.7 8.6 6.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK38732.2 - 1.6 8.8 4.8 3.2 7.8 4.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain SHS2_Rpb7-N PF03876.17 EDK38733.2 - 1.5e-17 63.8 0.0 2.4e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EDK38733.2 - 1.1e-16 60.9 0.1 1.9e-16 60.2 0.1 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 EDK38733.2 - 0.04 14.1 0.0 0.06 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Ribosomal_L13 PF00572.18 EDK38734.2 - 1.1e-42 145.2 0.3 2e-42 144.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L13 Sif PF06767.11 EDK38734.2 - 0.1 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Sif protein RNA_pol_Rpb2_6 PF00562.28 EDK38735.2 - 8.1e-125 416.9 0.0 1.4e-124 416.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDK38735.2 - 2.1e-68 229.9 0.1 3.1e-68 229.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDK38735.2 - 1.6e-49 168.2 0.0 2.9e-49 167.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDK38735.2 - 2e-34 117.8 0.2 4.6e-34 116.7 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDK38735.2 - 2.1e-25 88.8 0.3 4.4e-25 87.7 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDK38735.2 - 2.2e-24 85.4 0.1 5.3e-24 84.2 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDK38735.2 - 2.1e-23 82.6 0.4 6.5e-23 81.1 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 EDK38735.2 - 0.0099 16.6 0.2 0.028 15.1 0.2 1.8 1 0 0 1 1 1 1 MRN-interacting protein RNA_pol_Rpb2_45 PF10385.9 EDK38735.2 - 0.28 11.5 0.7 3.8 7.8 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Ribosomal_L23 PF00276.20 EDK38736.2 - 2.2e-10 40.8 0.0 4.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 TB2_DP1_HVA22 PF03134.19 EDK38737.2 - 9.5e-09 35.1 3.3 2.6e-08 33.7 1.9 2.2 3 0 0 3 3 3 1 TB2/DP1, HVA22 family ISN1 PF06437.11 EDK38738.2 - 5.2e-181 602.0 0.0 5.9e-181 601.8 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Ribosomal_S4e PF00900.20 EDK38739.1 - 5.6e-38 128.7 0.4 1.9e-37 127.0 0.2 1.8 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDK38739.1 - 9.2e-25 86.0 0.1 1.8e-24 85.1 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EDK38739.1 - 3.3e-08 33.5 0.1 1.4e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.25 EDK38739.1 - 3.9e-08 32.9 0.0 8.5e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EDK38739.1 - 3e-05 23.8 1.8 3e-05 23.8 1.8 3.2 3 0 0 3 3 3 1 KOW motif CIA30 PF08547.12 EDK38740.2 - 3.1e-44 150.8 0.0 4e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) SGBP_B_XBD PF18329.1 EDK38740.2 - 0.013 15.4 0.6 0.077 12.9 0.0 2.0 1 1 1 2 2 2 0 Surface glycan-binding protein B xyloglucan binding domain CBM_11 PF03425.13 EDK38740.2 - 0.066 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Choline_transpo PF04515.12 EDK38741.2 - 2.6e-09 36.7 3.2 2.6e-09 36.7 3.2 2.5 1 1 2 3 3 3 1 Plasma-membrane choline transporter Phage_holin_3_6 PF07332.11 EDK38741.2 - 1.8 8.6 17.2 2.2e+02 1.9 17.2 2.5 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Ndc1_Nup PF09531.10 EDK38741.2 - 7 5.2 15.4 16 4.1 15.4 1.5 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Choline_transpo PF04515.12 EDK38742.1 - 1.4e-43 149.4 9.2 1.5e-43 149.2 9.2 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter Metallophos_2 PF12850.7 EDK38743.2 - 6.3e-11 42.7 0.0 1.2e-10 41.8 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RR_TM4-6 PF06459.12 EDK38743.2 - 0.00093 19.1 2.1 0.001 18.9 2.1 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 EDK38743.2 - 0.0032 17.7 1.0 0.0052 17.0 1.0 1.4 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Na_trans_assoc PF06512.13 EDK38743.2 - 0.008 16.5 4.9 0.01 16.2 4.9 1.2 1 0 0 1 1 1 1 Sodium ion transport-associated SDA1 PF05285.12 EDK38743.2 - 0.012 15.1 10.7 0.015 14.7 10.7 1.1 1 0 0 1 1 1 0 SDA1 CagX PF03524.15 EDK38743.2 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Conjugal transfer protein Connexin PF00029.19 EDK38743.2 - 0.014 15.2 1.0 0.018 14.8 1.0 1.1 1 0 0 1 1 1 0 Connexin RPA43_OB PF17875.1 EDK38743.2 - 0.016 15.9 4.2 0.025 15.2 4.2 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF2722 PF10846.8 EDK38743.2 - 0.017 14.1 4.0 0.026 13.5 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RNA_pol_Rpc4 PF05132.14 EDK38743.2 - 0.046 14.2 3.7 0.079 13.4 3.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF262 PF03235.14 EDK38743.2 - 0.058 13.6 1.9 0.098 12.8 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 Presenilin PF01080.17 EDK38743.2 - 0.064 12.0 0.6 0.064 12.0 0.6 1.1 1 0 0 1 1 1 0 Presenilin DUF4637 PF15470.6 EDK38743.2 - 0.071 12.8 11.6 0.1 12.3 11.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) MCM_bind PF09739.9 EDK38743.2 - 0.1 11.0 6.2 0.17 10.3 6.2 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Tim54 PF11711.8 EDK38743.2 - 0.15 10.8 9.4 0.22 10.3 9.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 EDK38743.2 - 0.23 10.6 4.2 0.33 10.1 4.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SpoIIP PF07454.11 EDK38743.2 - 0.29 10.5 12.5 1 8.8 12.0 1.8 1 1 1 2 2 2 0 Stage II sporulation protein P (SpoIIP) RRN3 PF05327.11 EDK38743.2 - 0.31 9.5 4.7 0.41 9.1 4.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM176 PF14851.6 EDK38743.2 - 0.71 9.5 8.6 1.2 8.8 8.6 1.3 1 0 0 1 1 1 0 FAM176 family EIIBC-GUT_N PF03612.14 EDK38743.2 - 0.72 9.6 3.5 1.1 9.0 3.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Afi1 PF07792.12 EDK38743.2 - 0.92 10.0 8.0 1.9 9.0 8.0 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop14 PF04147.12 EDK38743.2 - 0.94 7.6 15.0 1.3 7.1 15.0 1.2 1 0 0 1 1 1 0 Nop14-like family Cytomega_UL84 PF06284.11 EDK38743.2 - 1.1 7.6 6.7 1.8 7.0 6.7 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Vfa1 PF08432.10 EDK38743.2 - 1.5 9.1 12.6 2.7 8.3 12.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TFIIF_alpha PF05793.12 EDK38743.2 - 1.6 7.3 19.9 2.1 6.9 19.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NOA36 PF06524.12 EDK38743.2 - 3 7.1 9.7 4.1 6.7 9.7 1.1 1 0 0 1 1 1 0 NOA36 protein Ferlin_C PF16165.5 EDK38743.2 - 3.4 7.6 6.9 5.2 7.0 6.9 1.2 1 0 0 1 1 1 0 Ferlin C-terminus SspB PF04386.13 EDK38743.2 - 7.7 6.4 9.9 13 5.6 9.9 1.4 1 0 0 1 1 1 0 Stringent starvation protein B NOT2_3_5 PF04153.18 EDK38744.2 - 2.1e-33 115.2 0.2 2.9e-33 114.8 0.2 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AAA_18 PF13238.6 EDK38745.1 - 3e-28 99.0 0.3 4.9e-28 98.3 0.1 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 EDK38745.1 - 1.6e-05 25.4 0.0 5.5e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDK38745.1 - 8.1e-05 23.1 0.0 0.00029 21.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EDK38745.1 - 0.00031 20.9 0.0 0.19 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain UCMA PF17085.5 EDK38745.1 - 0.00036 20.6 0.0 0.00055 19.9 0.0 1.3 1 0 0 1 1 1 1 Unique cartilage matrix associated protein AAA_16 PF13191.6 EDK38745.1 - 0.00048 20.5 0.0 0.00081 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EDK38745.1 - 0.00051 20.3 0.0 0.0017 18.7 0.0 1.9 2 1 1 3 3 3 1 AAA domain Thymidylate_kin PF02223.17 EDK38745.1 - 0.0015 18.2 0.1 0.23 11.1 0.1 2.2 2 0 0 2 2 2 1 Thymidylate kinase CPT PF07931.12 EDK38745.1 - 0.0019 18.1 0.0 0.0043 16.9 0.0 1.7 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 EDK38745.1 - 0.0021 18.3 0.0 0.0029 17.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDK38745.1 - 0.0024 17.9 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) KTI12 PF08433.10 EDK38745.1 - 0.0024 17.4 0.0 0.0047 16.4 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 dNK PF01712.19 EDK38745.1 - 0.0028 17.5 2.2 0.38 10.6 0.0 2.4 1 1 1 2 2 2 1 Deoxynucleoside kinase Cytidylate_kin2 PF13189.6 EDK38745.1 - 0.0087 16.2 0.0 0.028 14.5 0.0 1.9 1 1 1 2 2 2 1 Cytidylate kinase-like family RNA_helicase PF00910.22 EDK38745.1 - 0.012 16.0 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase ADK PF00406.22 EDK38745.1 - 0.014 15.5 0.5 2.8 8.0 0.0 2.3 1 1 1 2 2 2 0 Adenylate kinase NACHT PF05729.12 EDK38745.1 - 0.028 14.3 0.0 0.096 12.6 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EDK38745.1 - 0.039 13.2 0.0 0.081 12.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Glutaredoxin PF00462.24 EDK38745.1 - 0.04 14.1 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Glutaredoxin DUF3576 PF12100.8 EDK38745.1 - 0.049 13.7 0.4 0.22 11.6 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3576) Viral_helicase1 PF01443.18 EDK38745.1 - 0.058 13.1 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase tRNA_lig_kinase PF08303.11 EDK38745.1 - 0.086 12.9 0.1 1.6 8.8 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain PRK PF00485.18 EDK38745.1 - 0.12 12.0 0.0 0.39 10.4 0.0 1.8 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family Mg_chelatase PF01078.21 EDK38745.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 EDK38745.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EDK38745.1 - 0.18 11.7 1.0 0.4 10.6 0.1 2.1 2 1 0 2 2 2 0 NTPase Heme_oxygenase PF01126.20 EDK38746.1 - 9.4e-27 94.1 0.9 1.7e-26 93.3 0.9 1.4 1 1 0 1 1 1 1 Heme oxygenase Ribosomal_S6 PF01250.17 EDK38746.1 - 0.0095 16.2 0.1 0.028 14.7 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S6 Cas_Csn2 PF09711.10 EDK38746.1 - 0.016 14.9 1.2 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csn2) AA_permease PF00324.21 EDK38747.2 - 9.3e-125 416.9 35.2 1.1e-124 416.7 35.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK38747.2 - 2e-36 125.7 35.4 2.4e-36 125.5 35.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4635 PF15466.6 EDK38747.2 - 0.12 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) GET2 PF08690.10 EDK38747.2 - 0.16 11.6 0.1 0.34 10.6 0.1 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 PRELI PF04707.14 EDK38748.2 - 1.7e-38 131.9 0.1 2.1e-38 131.6 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family M-inducer_phosp PF06617.13 EDK38750.2 - 0.00076 18.9 2.2 0.00089 18.6 2.2 1.2 1 0 0 1 1 1 1 M-phase inducer phosphatase Cwf_Cwc_15 PF04889.12 EDK38750.2 - 0.79 9.4 10.5 1 9.1 10.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EDK38750.2 - 2.7 7.2 13.1 3.4 6.9 13.1 1.1 1 0 0 1 1 1 0 NOA36 protein Prefoldin_2 PF01920.20 EDK38751.2 - 5.8e-20 71.2 9.1 6.4e-20 71.1 9.1 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EDK38751.2 - 0.0055 16.6 4.0 0.0067 16.3 4.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF5082 PF16888.5 EDK38751.2 - 0.016 15.5 6.1 0.14 12.5 6.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) TACC_C PF05010.14 EDK38751.2 - 0.017 14.9 6.4 0.19 11.5 1.1 2.0 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1192 PF06698.11 EDK38751.2 - 0.018 15.1 1.0 0.038 14.0 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF3727 PF12527.8 EDK38751.2 - 0.021 15.1 1.0 0.032 14.5 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3727) Spc24 PF08286.11 EDK38751.2 - 0.097 12.9 9.5 1.3 9.3 1.8 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 EDK38751.2 - 0.16 12.4 6.8 0.33 11.4 0.8 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) FliJ PF02050.16 EDK38751.2 - 0.27 11.4 7.7 1.5 9.1 0.8 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.9 EDK38751.2 - 0.3 11.1 10.9 1.4 8.9 2.1 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.10 EDK38751.2 - 0.54 10.6 8.2 2.4 8.5 0.6 3.0 2 1 1 3 3 3 0 Tup N-terminal Fib_alpha PF08702.10 EDK38751.2 - 0.88 9.7 7.1 1.5 9.0 7.1 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family YabA PF06156.13 EDK38751.2 - 5.5 7.7 7.7 33 5.2 7.7 1.9 1 1 0 1 1 1 0 Initiation control protein YabA COQ9 PF08511.11 EDK38752.2 - 4.1e-28 97.0 0.0 8.7e-28 95.9 0.0 1.5 1 0 0 1 1 1 1 COQ9 POC1 PF10450.9 EDK38753.1 - 3.2e-05 23.1 0.0 4.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 POC1 chaperone Mpv17_PMP22 PF04117.12 EDK38754.2 - 5e-21 74.7 3.6 8.8e-21 73.9 2.5 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family CEP44 PF15007.6 EDK38754.2 - 0.15 12.2 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 NADH_u_ox_C PF12853.7 EDK38755.2 - 1.6e-47 159.4 1.0 2.3e-47 158.9 1.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit NADH-u_ox-rdase PF10785.9 EDK38755.2 - 8.3e-30 103.3 0.0 1.2e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit CLASP_N PF12348.8 EDK38756.2 - 1.8e-11 44.1 0.7 5.3e-10 39.3 0.4 2.8 3 0 0 3 3 3 1 CLASP N terminal Cnd1 PF12717.7 EDK38756.2 - 4.4e-06 26.8 1.5 0.00013 22.0 1.1 2.8 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EDK38756.2 - 4.9e-05 23.2 4.6 5.6 7.5 0.1 5.8 6 0 0 6 6 6 2 HEAT repeat WSN PF02206.18 EDK38756.2 - 0.054 13.4 0.2 0.29 11.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function MINDY_DUB PF04424.13 EDK38756.2 - 0.11 12.6 1.5 0.39 10.8 0.0 2.8 2 1 1 3 3 3 0 MINDY deubiquitinase ETF PF01012.21 EDK38757.1 - 4.5e-42 144.0 0.2 5.5e-42 143.7 0.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain AAA_14 PF13173.6 EDK38758.2 - 0.0073 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDK38758.2 - 0.038 14.4 0.0 0.073 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 EDK38758.2 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 EDK38758.2 - 0.16 12.5 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDK38758.2 - 0.21 12.0 0.0 0.35 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AA_permease PF00324.21 EDK38759.2 - 6.2e-141 470.3 33.1 7e-141 470.1 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK38759.2 - 1.2e-41 142.9 34.7 1.5e-41 142.6 34.7 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EDK38759.2 - 0.64 8.8 3.4 0.3 9.8 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) SlyX PF04102.12 EDK38760.2 - 0.0004 21.0 1.2 0.067 13.8 0.0 2.7 2 1 0 2 2 2 1 SlyX Mer2 PF09074.10 EDK38760.2 - 0.0038 17.1 2.2 0.0087 15.9 1.3 1.8 1 1 1 2 2 2 1 Mer2 Fib_alpha PF08702.10 EDK38760.2 - 0.017 15.3 1.7 1.1 9.5 0.2 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HrpB7 PF09486.10 EDK38760.2 - 0.018 15.4 2.8 1.9 8.8 0.1 2.4 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4191 PF13829.6 EDK38760.2 - 0.066 12.6 0.1 0.15 11.4 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) TFB6 PF17110.5 EDK38760.2 - 0.12 12.1 0.4 0.16 11.7 0.4 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH KxDL PF10241.9 EDK38760.2 - 0.9 9.9 5.1 1.3 9.3 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein LSM PF01423.22 EDK38761.1 - 3.1e-11 42.8 0.2 6.5e-11 41.8 0.0 1.6 2 0 0 2 2 2 1 LSM domain Aldolase_II PF00596.21 EDK38762.2 - 1.2e-44 152.5 0.0 1.4e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Nop PF01798.18 EDK38763.2 - 5.3e-83 278.0 0.2 5.3e-83 278.0 0.2 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDK38763.2 - 8.8e-19 67.7 2.3 8.8e-19 67.7 2.3 2.4 2 1 0 2 2 2 1 NOP5NT (NUC127) domain DUF859 PF05895.12 EDK38763.2 - 0.15 10.5 0.0 0.21 10.0 0.0 1.2 1 0 0 1 1 1 0 Siphovirus protein of unknown function (DUF859) GAGA_bind PF06217.12 EDK38763.2 - 0.88 9.8 20.2 1.7 8.9 20.2 1.5 1 0 0 1 1 1 0 GAGA binding protein-like family Paf1 PF03985.13 EDK38763.2 - 3.3 6.6 32.0 6 5.8 32.0 1.3 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 EDK38763.2 - 6.4 6.5 29.9 2.1 8.1 27.0 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Dna2 PF08696.11 EDK38764.2 - 8.7e-54 182.4 0.0 2.2e-53 181.1 0.0 1.8 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EDK38764.2 - 1e-47 162.3 0.3 1.7e-46 158.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDK38764.2 - 4.3e-32 111.9 0.3 1.2e-14 54.8 0.0 2.9 1 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDK38764.2 - 3.6e-13 49.7 0.0 8.5e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK38764.2 - 2.1e-11 44.3 0.0 4.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDK38764.2 - 2.2e-07 30.9 0.7 0.092 12.5 0.1 4.0 2 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 EDK38764.2 - 4.3e-07 30.2 0.7 1.9e-05 24.8 0.2 2.7 2 0 0 2 2 2 1 Domain of unknown function DUF83 UvrD-helicase PF00580.21 EDK38764.2 - 9.4e-06 25.4 0.9 3.8e-05 23.4 0.0 2.5 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_18 PF13238.6 EDK38764.2 - 0.0003 21.4 0.1 0.0011 19.5 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDK38764.2 - 0.00084 19.8 0.1 0.0025 18.2 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain Helicase_RecD PF05127.14 EDK38764.2 - 0.0009 19.1 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 Helicase PIF1 PF05970.14 EDK38764.2 - 0.0066 15.7 0.4 0.21 10.7 0.1 2.9 4 0 0 4 4 3 1 PIF1-like helicase SRP54 PF00448.22 EDK38764.2 - 0.0094 15.6 0.1 0.018 14.7 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MobB PF03205.14 EDK38764.2 - 0.013 15.4 0.1 0.03 14.2 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 EDK38764.2 - 0.017 14.6 0.1 0.056 12.9 0.1 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region MeaB PF03308.16 EDK38764.2 - 0.019 14.0 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PhoH PF02562.16 EDK38764.2 - 0.023 14.1 0.0 0.11 11.9 0.0 2.0 1 1 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 EDK38764.2 - 0.026 14.1 0.1 0.074 12.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDK38764.2 - 0.03 14.6 0.0 0.16 12.2 0.0 2.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDK38764.2 - 0.031 14.0 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2075 PF09848.9 EDK38764.2 - 0.053 12.8 0.0 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CtIP_N PF10482.9 EDK38764.2 - 0.057 13.5 0.8 0.21 11.6 0.8 1.9 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain AAA PF00004.29 EDK38764.2 - 0.063 13.7 0.0 0.19 12.1 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 EDK38764.2 - 0.089 12.9 0.5 0.6 10.2 0.2 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 EDK38764.2 - 0.089 12.7 0.2 0.23 11.3 0.2 1.7 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 EDK38764.2 - 0.09 12.9 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EDK38764.2 - 0.13 11.8 0.1 0.28 10.8 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EDK38764.2 - 0.67 10.0 4.1 0.35 10.9 1.0 2.1 2 0 0 2 2 1 0 Helicase HerA, central domain Sel1 PF08238.12 EDK38765.2 - 2.9e-27 94.5 19.6 0.00015 22.3 0.2 9.8 10 0 0 10 10 10 6 Sel1 repeat TPR_19 PF14559.6 EDK38765.2 - 0.00063 20.2 2.3 2.9 8.5 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF2615 PF11027.8 EDK38765.2 - 0.032 14.3 0.1 0.09 12.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) TPR_16 PF13432.6 EDK38765.2 - 0.072 13.8 8.1 8.7 7.1 0.0 5.6 6 1 1 7 7 7 0 Tetratricopeptide repeat V_ATPase_I PF01496.19 EDK38766.2 - 1.2e-284 946.3 5.9 1.3e-219 731.2 11.5 2.0 2 0 0 2 2 2 2 V-type ATPase 116kDa subunit family Dor1 PF04124.12 EDK38766.2 - 0.07 11.8 0.1 0.16 10.6 0.1 1.5 1 0 0 1 1 1 0 Dor1-like family HOOK PF05622.12 EDK38766.2 - 0.21 9.7 0.0 0.33 9.1 0.0 1.1 1 0 0 1 1 1 0 HOOK protein NDC10_II PF16787.5 EDK38767.2 - 3.2e-31 108.6 1.3 7.4e-31 107.4 0.1 2.2 2 1 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 EDK38767.2 - 0.011 16.0 0.8 0.034 14.5 0.8 1.8 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes HLH PF00010.26 EDK38768.2 - 1.9e-18 66.2 1.3 3.1e-16 59.0 0.1 3.4 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain DUF2014 PF09427.10 EDK38768.2 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) Med31 PF05669.12 EDK38768.2 - 0.036 14.1 0.0 2.9 8.0 0.0 2.6 2 0 0 2 2 2 0 SOH1 GIDA PF01134.22 EDK38768.2 - 0.097 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A zf-rbx1 PF12678.7 EDK38769.2 - 2e-10 40.8 6.4 4e-10 39.8 6.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDK38769.2 - 4.7e-08 33.2 9.4 1.9e-07 31.3 9.4 2.0 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDK38769.2 - 5.6e-07 29.4 5.0 1e-06 28.6 5.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDK38769.2 - 1.5e-06 28.0 7.2 2.9e-06 27.1 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK38769.2 - 1.3e-05 25.1 2.6 3.5e-05 23.7 2.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDK38769.2 - 1.9e-05 24.4 4.8 1.9e-05 24.4 4.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK38769.2 - 2.7e-05 23.9 4.2 5.5e-05 22.9 4.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EDK38769.2 - 0.00013 21.6 7.4 0.0074 16.0 2.4 2.7 2 0 0 2 2 2 2 RING-like zinc finger zf-ANAPC11 PF12861.7 EDK38769.2 - 0.0013 18.7 2.1 0.0027 17.7 2.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EDK38769.2 - 0.0036 17.4 2.4 0.0094 16.1 2.4 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EDK38769.2 - 0.0079 15.8 2.9 0.0079 15.8 2.9 2.3 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EDK38769.2 - 0.012 15.4 7.6 0.045 13.6 7.6 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2921 PF11145.8 EDK38769.2 - 0.021 12.7 1.3 0.16 9.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2921) RINGv PF12906.7 EDK38769.2 - 1.6 8.9 5.6 4.9 7.4 5.6 1.9 1 1 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 EDK38769.2 - 5.9 7.0 6.6 5.7 7.1 4.5 2.1 2 0 0 2 2 2 0 Zinc-finger RE_EcoO109I PF14511.6 EDK38771.2 - 0.03 13.9 1.3 0.048 13.2 0.3 1.9 2 0 0 2 2 2 0 Type II restriction endonuclease EcoO109I DUF445 PF04286.12 EDK38771.2 - 0.095 12.5 13.1 0.14 12.0 9.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF445) Phasin PF05597.11 EDK38771.2 - 0.097 12.7 3.3 2.5 8.1 0.1 2.7 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) AF0941-like PF14591.6 EDK38771.2 - 0.15 12.7 4.6 0.47 11.0 4.6 1.8 1 1 0 1 1 1 0 AF0941-like NusB PF01029.18 EDK38771.2 - 0.15 12.3 2.5 0.48 10.7 0.1 2.6 1 1 1 2 2 2 0 NusB family Complex1_LYR_2 PF13233.6 EDK38772.1 - 3.7e-19 69.2 0.0 5.4e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EDK38772.1 - 2.6e-09 37.0 0.0 5.4e-09 36.0 0.0 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Glyco_transf_15 PF01793.16 EDK38773.2 - 1.5e-112 376.1 12.2 1.8e-112 375.8 12.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase His_kinase PF06580.13 EDK38773.2 - 0.093 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase DUF4199 PF13858.6 EDK38773.2 - 0.095 13.1 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) GLTP PF08718.11 EDK38774.1 - 6.5e-47 159.5 0.0 9.3e-47 159.0 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) SseC PF04888.12 EDK38774.1 - 0.022 14.4 0.0 0.026 14.1 0.0 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family ROK PF00480.20 EDK38775.2 - 0.2 11.1 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 ROK family Glyco_hydro_3_C PF01915.22 EDK38776.2 - 5.6e-63 212.6 0.0 9.3e-63 211.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDK38776.2 - 4e-43 148.0 0.0 8.3e-43 147.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EDK38776.2 - 1.8e-24 85.6 0.1 3.6e-24 84.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EDK38776.2 - 1.5e-13 50.8 0.0 2.8e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 PA14 domain DUF2841 PF11001.8 EDK38777.2 - 6.7e-34 116.6 2.4 6.7e-34 116.6 2.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2841) Nop PF01798.18 EDK38779.2 - 9.4e-86 287.0 0.1 9.4e-86 287.0 0.1 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDK38779.2 - 1.2e-20 73.6 0.5 1.2e-20 73.6 0.5 2.7 2 1 0 2 2 2 1 NOP5NT (NUC127) domain YL1 PF05764.13 EDK38779.2 - 0.23 11.6 31.0 0.32 11.1 31.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein RNA_polI_A34 PF08208.11 EDK38779.2 - 0.27 11.3 47.9 0.43 10.6 47.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 EDK38779.2 - 0.43 10.4 23.1 0.71 9.7 23.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 EDK38779.2 - 1.6 8.9 16.6 3.2 8.0 16.6 1.5 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 EDK38779.2 - 4.3 5.5 26.3 6.7 4.9 26.3 1.3 1 0 0 1 1 1 0 CDC45-like protein RP-C_C PF11800.8 EDK38779.2 - 4.7 7.2 15.7 26 4.8 0.0 2.5 3 0 0 3 3 3 0 Replication protein C C-terminal region DDHD PF02862.17 EDK38779.2 - 5.3 7.1 10.3 10 6.2 10.3 1.5 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.6 EDK38779.2 - 8.9 6.0 15.8 16 5.2 15.8 1.4 1 0 0 1 1 1 0 AAA domain Fungal_trans_2 PF11951.8 EDK38780.2 - 1.8e-77 260.8 1.1 2.5e-77 260.3 1.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK38780.2 - 3e-07 30.4 9.8 5.4e-07 29.6 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 EDK38780.2 - 2.8 8.5 9.1 6.8 7.3 9.1 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region UQ_con PF00179.26 EDK38781.1 - 3.4e-52 175.8 0.0 3.8e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDK38781.1 - 0.0025 18.1 0.0 0.0037 17.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDK38781.1 - 0.0044 16.7 0.0 0.0052 16.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDK38781.1 - 0.027 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 UEV domain Bromodomain PF00439.25 EDK38782.2 - 6.6e-17 61.4 0.2 2.7e-16 59.4 0.1 2.1 2 0 0 2 2 2 1 Bromodomain DUF2722 PF10846.8 EDK38782.2 - 0.5 9.3 20.7 0.014 14.4 12.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Nse4_C PF08743.10 EDK38782.2 - 0.51 10.6 4.3 0.58 10.5 0.0 3.0 2 1 0 2 2 2 0 Nse4 C-terminal Bromo_TP PF07524.13 EDK38783.2 - 1.9e-07 31.0 0.1 9.7e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 Bromodomain associated Bromo_TP_like PF17027.5 EDK38783.2 - 0.00016 21.8 0.8 0.0004 20.5 0.1 2.1 2 0 0 2 2 2 1 Histone-fold protein DUF5601 PF18151.1 EDK38783.2 - 0.0062 16.8 0.3 0.04 14.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) RCC1 PF00415.18 EDK38784.2 - 1.5e-11 44.8 0.1 0.00046 20.8 0.0 5.1 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EDK38784.2 - 3.1e-09 37.1 0.2 0.0002 21.5 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EDK38784.2 - 3.4e-07 29.9 1.8 7.1e-06 25.7 0.1 3.7 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EDK38784.2 - 3.3e-06 27.6 0.6 8.8e-06 26.2 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK38784.2 - 0.0019 18.7 1.6 0.012 16.2 1.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK38784.2 - 0.0024 18.2 2.1 0.11 13.1 0.3 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EDK38784.2 - 0.15 12.4 0.8 4.1 7.8 0.1 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) ubiquitin PF00240.23 EDK38785.2 - 0.011 15.5 0.3 4.9 7.0 0.1 2.9 2 0 0 2 2 2 0 Ubiquitin family PI3K_p85B PF02192.16 EDK38785.2 - 0.055 13.2 0.0 22 4.9 0.0 3.1 2 1 0 2 2 2 0 PI3-kinase family, p85-binding domain zf-Mss51 PF13824.6 EDK38786.2 - 9.5e-19 67.3 0.6 1.9e-18 66.3 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.11 EDK38786.2 - 0.039 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain PRKCSH PF07915.13 EDK38787.2 - 8.1e-18 65.2 1.3 3e-17 63.4 1.3 2.1 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Yos9_DD PF17880.1 EDK38787.2 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Yos9 dimerzation domain CAP18_C PF12153.8 EDK38788.1 - 0.0082 16.0 0.4 0.012 15.5 0.4 1.2 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) SepZ PF06066.11 EDK38788.1 - 0.019 15.2 0.0 0.02 15.1 0.0 1.1 1 0 0 1 1 1 0 SepZ Baculo_PEP_C PF04513.12 EDK38788.1 - 0.089 12.8 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF382 PF04037.13 EDK38789.2 - 2.9e-54 182.6 0.3 8.5e-54 181.1 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EDK38789.2 - 7.1e-16 57.8 0.2 1.4e-15 56.9 0.2 1.5 1 0 0 1 1 1 1 PSP Zn_clus PF00172.18 EDK38790.2 - 4.8e-05 23.4 8.1 9.4e-05 22.5 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 EDK38790.2 - 0.19 11.3 7.6 0.056 13.1 3.4 2.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Molybdopterin PF00384.22 EDK38791.2 - 4.3e-68 230.2 0.0 1.4e-65 222.0 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EDK38791.2 - 9e-21 73.7 0.6 2.2e-20 72.5 0.6 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 EDK38791.2 - 3.5e-16 59.6 0.1 9.3e-16 58.3 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EDK38791.2 - 4.4e-15 54.9 0.5 4.4e-15 54.9 0.5 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 EDK38791.2 - 1.7e-08 34.3 0.3 1.7e-08 34.3 0.3 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Lyx_isomer PF07385.12 EDK38791.2 - 0.014 14.7 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 D-lyxose isomerase TPP_enzyme_M PF00205.22 EDK38791.2 - 0.015 15.0 0.2 0.23 11.2 0.1 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain TFX_C PF14601.6 EDK38791.2 - 0.066 13.2 0.1 0.69 9.9 0.0 2.3 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term Fer4 PF00037.27 EDK38791.2 - 0.11 12.4 1.1 3.4 7.7 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EDK38791.2 - 0.31 11.1 2.1 4.7 7.4 2.1 2.6 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4_4 PF12800.7 EDK38791.2 - 8.2 7.2 6.5 1.5 9.5 1.6 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain DUF4246 PF14033.6 EDK38792.2 - 2.4e-130 435.7 0.7 3.4e-130 435.2 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) DUF2034 PF10356.9 EDK38794.2 - 2.7e-51 173.6 0.0 3.5e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EDK38794.2 - 0.00022 21.2 0.0 0.0072 16.3 0.0 2.3 2 0 0 2 2 2 1 Restriction endonuclease Glyco_hydro_18 PF00704.28 EDK38795.2 - 1.6e-29 103.7 0.7 4.7e-29 102.1 0.7 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 NAD_binding_5 PF07994.12 EDK38796.1 - 4e-143 476.6 0.0 4.6e-143 476.4 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EDK38796.1 - 9.3e-45 151.4 0.3 2.6e-44 149.9 0.3 1.8 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase AMP-binding PF00501.28 EDK38797.2 - 6.3e-81 272.1 0.0 8.7e-81 271.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDK38797.2 - 0.0037 18.2 0.0 0.0084 17.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Asparaginase PF00710.20 EDK38798.2 - 4.4e-58 196.0 0.0 6.2e-58 195.5 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EDK38798.2 - 2.7e-14 53.3 0.0 7.6e-14 51.9 0.0 1.8 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain Abhydrolase_6 PF12697.7 EDK38799.2 - 1.5e-08 35.5 0.1 2.3e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK38799.2 - 0.001 18.4 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK38799.2 - 0.057 13.1 0.0 0.078 12.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EDK38799.2 - 0.073 12.7 0.1 0.13 11.9 0.1 1.5 2 0 0 2 2 2 0 Putative esterase Fanconi_A PF03511.14 EDK38799.2 - 0.086 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Fanconi anaemia group A protein CT_C_D PF02682.16 EDK38800.2 - 1.6e-06 28.0 0.0 2.3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D CPSase_L_D2 PF02786.17 EDK38801.2 - 9.4e-56 188.6 0.0 1.4e-55 188.1 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDK38801.2 - 2.7e-38 130.9 0.1 4.8e-38 130.1 0.1 1.4 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Dala_Dala_lig_C PF07478.13 EDK38801.2 - 6.3e-12 45.5 0.0 9.5e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_carb_C PF02785.19 EDK38801.2 - 2e-08 34.3 0.0 1.6e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 EDK38801.2 - 7.5e-06 25.6 0.0 1.3e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDK38801.2 - 0.0085 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 EDK38801.2 - 0.057 12.9 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 EDK38801.2 - 0.094 12.3 0.0 0.94 9.0 0.0 2.3 3 0 0 3 3 3 0 RimK-like ATP-grasp domain ATPgrasp_Ter PF15632.6 EDK38801.2 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.6 EDK38801.2 - 0.14 11.7 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain LamB_YcsF PF03746.16 EDK38802.2 - 4.8e-63 213.0 0.0 5.7e-63 212.8 0.0 1.1 1 0 0 1 1 1 1 LamB/YcsF family ComA PF02679.15 EDK38802.2 - 0.12 11.9 0.0 0.96 8.9 0.0 1.9 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) SAB PF04382.13 EDK38805.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 SAB domain Bac_export_2 PF01312.19 EDK38805.1 - 0.15 11.2 0.5 3.1 6.9 0.0 2.1 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family RDD PF06271.12 EDK38805.1 - 0.24 11.6 8.7 0.11 12.7 5.1 1.9 2 0 0 2 2 2 0 RDD family DUF2207 PF09972.9 EDK38805.1 - 2.6 6.7 6.1 12 4.6 5.8 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Aldedh PF00171.22 EDK38806.1 - 7.6e-163 542.3 0.2 9.4e-163 542.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDK38806.1 - 9.8e-05 21.9 0.1 0.026 14.0 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) LuxC PF05893.14 EDK38806.1 - 0.0076 15.3 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) COX6B PF02297.17 EDK38807.1 - 8.8e-23 80.3 6.3 1.2e-22 80.0 6.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.9 EDK38807.1 - 0.26 11.6 3.1 7.2 7.0 2.8 2.4 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 TRAPPC9-Trs120 PF08626.11 EDK38808.2 - 0 1094.1 0.6 0 1093.9 0.6 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 EDK38808.2 - 0.13 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Proteasome PF00227.26 EDK38809.2 - 1.1e-48 165.3 0.2 1.4e-48 165.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EDK38809.2 - 9.1e-11 41.0 0.2 9.1e-11 41.0 0.2 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Aha1_N PF09229.11 EDK38810.2 - 4.6e-39 133.8 0.1 8.1e-39 133.0 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EDK38810.2 - 2.2e-17 63.5 0.0 4e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Serglycin PF04360.12 EDK38810.2 - 0.025 14.5 3.2 0.051 13.5 3.2 1.5 1 0 0 1 1 1 0 Serglycin TFIIF_alpha PF05793.12 EDK38810.2 - 0.47 9.0 5.1 0.62 8.6 5.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AF-4 PF05110.13 EDK38810.2 - 2.8 5.9 8.7 3.6 5.6 8.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM199X PF15814.5 EDK38810.2 - 3.5 6.6 8.2 0.37 9.8 2.5 1.9 2 0 0 2 2 2 0 Protein family FAM199X ADH_zinc_N PF00107.26 EDK38811.1 - 9.9e-19 67.6 0.3 2e-18 66.6 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK38811.1 - 2.3e-07 30.5 0.1 4.9e-07 29.4 0.1 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDK38811.1 - 0.00085 20.4 0.0 0.0013 19.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDK38811.1 - 0.011 15.0 2.0 0.018 14.3 1.5 1.5 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HycI PF01750.18 EDK38811.1 - 0.015 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase maturation protease Sacchrp_dh_NADP PF03435.18 EDK38811.1 - 0.017 15.4 0.2 0.035 14.3 0.2 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 EDK38811.1 - 0.025 14.1 0.2 0.057 13.0 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EDK38811.1 - 0.061 13.8 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Iso_dh PF00180.20 EDK38812.1 - 4.9e-97 325.2 0.0 6.1e-97 324.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Formyl_trans_N PF00551.19 EDK38813.1 - 1.2e-46 158.8 0.1 1.4e-46 158.6 0.1 1.0 1 0 0 1 1 1 1 Formyl transferase Baculo_Y142 PF04913.12 EDK38813.1 - 0.21 10.2 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 Baculovirus Y142 protein GTP_EFTU PF00009.27 EDK38814.1 - 2.7e-67 226.1 0.1 3.8e-67 225.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDK38814.1 - 8.9e-34 115.9 0.0 6.9e-33 113.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDK38814.1 - 3.2e-21 75.2 0.0 8.5e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDK38814.1 - 4.6e-15 55.8 0.2 1.7e-14 53.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDK38814.1 - 1e-13 51.1 0.0 2.8e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDK38814.1 - 0.00016 21.8 0.2 0.00034 20.7 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1279 PF06916.13 EDK38815.2 - 0.039 14.5 0.6 3.2 8.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) MLANA PF14991.6 EDK38815.2 - 0.094 13.0 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein melan-A Cu_amine_oxid PF01179.20 EDK38816.2 - 4.1e-147 490.4 0.0 5.2e-147 490.0 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EDK38816.2 - 2.8e-26 91.8 0.1 9.4e-26 90.2 0.1 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EDK38816.2 - 1.7e-20 73.0 0.0 4.1e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain RNA_Me_trans PF04252.13 EDK38817.1 - 7.7e-77 257.4 0.0 8.6e-77 257.2 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DDHD PF02862.17 EDK38818.2 - 1.7e-25 90.5 0.1 1.7e-25 90.5 0.1 2.5 2 1 0 2 2 2 1 DDHD domain WWE PF02825.20 EDK38818.2 - 0.0027 18.3 4.5 0.063 13.9 2.0 3.3 2 2 0 2 2 2 1 WWE domain Hydrolase_4 PF12146.8 EDK38818.2 - 0.0088 15.3 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDK38818.2 - 0.026 14.3 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein LIDHydrolase PF10230.9 EDK38818.2 - 0.039 13.5 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 EDK38818.2 - 0.072 12.7 0.1 0.33 10.5 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EDK38818.2 - 0.076 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.14 EDK38818.2 - 0.088 12.3 0.2 3.7 7.0 0.0 2.6 3 0 0 3 3 3 0 Putative serine esterase (DUF676) Thioesterase PF00975.20 EDK38818.2 - 0.11 12.5 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 Thioesterase domain CpxA_peri PF16527.5 EDK38818.2 - 0.19 12.1 0.1 0.19 12.1 0.1 2.4 3 0 0 3 3 3 0 Two-component sensor protein CpxA, periplasmic domain LCCL PF03815.19 EDK38819.2 - 2.5e-06 27.5 0.3 5.1e-06 26.5 0.3 1.5 1 0 0 1 1 1 1 LCCL domain Ribonuc_red_lgC PF02867.15 EDK38820.2 - 1.3e-188 627.8 0.0 3.1e-188 626.6 0.0 1.6 2 0 0 2 2 2 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDK38820.2 - 3.1e-23 81.6 0.0 8.6e-23 80.1 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDK38820.2 - 1.4e-15 57.6 0.1 4.1e-15 56.1 0.1 1.9 1 0 0 1 1 1 1 ATP cone domain PRP3 PF08572.10 EDK38821.2 - 1.3e-63 214.7 13.3 1.3e-63 214.7 13.3 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EDK38821.2 - 1.3e-42 145.3 0.1 1.3e-42 145.3 0.1 2.9 4 1 0 4 4 4 1 Protein of unknown function (DUF1115) RNR_inhib PF08591.10 EDK38821.2 - 0.46 11.8 6.1 2.3 9.6 0.0 2.9 2 1 0 2 2 2 0 Ribonucleotide reductase inhibitor HECT PF00632.25 EDK38822.2 - 6.8e-96 321.4 0.1 1.3e-95 320.5 0.1 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 EDK38822.2 - 3.1e-60 204.5 2.5 1.5e-59 202.2 2.5 2.1 1 1 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 EDK38822.2 - 1.4e-57 195.4 0.1 1.7e-56 191.8 0.0 3.0 2 1 0 2 2 2 1 Domain of Unknown Function (DUF913) UBM PF14377.6 EDK38822.2 - 1.8e-19 68.5 8.0 9.3e-10 37.6 0.2 3.1 2 0 0 2 2 2 2 Ubiquitin binding region DUF1682 PF07946.14 EDK38822.2 - 0.04 13.1 7.9 0.12 11.6 7.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF3338 PF11819.8 EDK38822.2 - 0.86 9.6 8.0 2.3 8.2 8.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) DUF3987 PF13148.6 EDK38822.2 - 5.2 6.0 7.0 9.1 5.2 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) 4HBT_2 PF13279.6 EDK38823.2 - 6.2e-09 36.4 0.1 9.8e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily LPD24 PF18839.1 EDK38823.2 - 0.066 13.5 0.4 0.2 11.9 0.1 1.9 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 zf-C2H2_6 PF13912.6 EDK38824.2 - 0.0008 19.3 5.0 0.0008 19.3 5.0 3.4 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDK38824.2 - 0.0023 18.6 32.6 0.67 11.0 0.1 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EDK38824.2 - 0.0074 16.7 20.5 0.079 13.5 6.5 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EDK38824.2 - 1.3 9.4 9.1 2.9 8.3 0.2 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding DZR PF12773.7 EDK38824.2 - 4.6 7.3 9.7 2.7 8.1 4.6 2.6 2 0 0 2 2 2 0 Double zinc ribbon ELO PF01151.18 EDK38825.2 - 1.6e-59 201.4 26.0 1.9e-59 201.2 26.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family OAD_gamma PF04277.13 EDK38825.2 - 1.1 9.9 0.0 1.1 9.9 0.0 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Glyco_transf_4 PF13439.6 EDK38825.2 - 9.7 6.2 7.3 0.55 10.2 0.8 2.2 2 1 1 3 3 3 0 Glycosyltransferase Family 4 CNH PF00780.22 EDK38826.2 - 6.6e-75 252.2 0.1 1.8e-74 250.8 0.0 1.7 2 0 0 2 2 2 1 CNH domain RhoGEF PF00621.20 EDK38826.2 - 8.5e-37 127.2 3.3 8.5e-37 127.2 3.3 2.0 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 EDK38826.2 - 1e-25 90.4 0.9 3.9e-25 88.5 0.9 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 EDK38826.2 - 1.2e-12 47.7 0.0 2.9e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) P21-Arc PF04062.14 EDK38827.2 - 4.8e-75 251.4 0.0 5.5e-75 251.2 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit ICMT PF04140.14 EDK38828.2 - 4.6e-16 59.0 2.4 1.1e-15 57.8 2.4 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EDK38828.2 - 1.6e-12 47.7 2.9 1.6e-12 47.7 2.9 2.3 2 0 0 2 2 2 1 Phospholipid methyltransferase NnrU PF07298.11 EDK38828.2 - 0.0019 17.7 6.6 0.0036 16.8 6.6 1.5 1 1 0 1 1 1 1 NnrU protein ICMT PF04140.14 EDK38829.2 - 1.6e-23 82.9 0.1 3.5e-23 81.8 0.1 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EDK38829.2 - 2.3e-11 44.0 0.4 2.3e-11 44.0 0.4 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EDK38829.2 - 0.00034 20.2 0.3 0.00034 20.2 0.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) NnrU PF07298.11 EDK38829.2 - 0.01 15.3 1.3 0.013 15.0 0.1 1.8 2 0 0 2 2 2 0 NnrU protein ArAE_2_N PF10337.9 EDK38829.2 - 0.071 12.1 0.0 0.096 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal FA_desaturase PF00487.24 EDK38830.2 - 5.9e-23 82.0 19.6 1.3e-22 80.8 19.6 1.5 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EDK38830.2 - 5.3e-05 23.4 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Mito_carr PF00153.27 EDK38831.2 - 1.1e-29 102.2 7.4 4.3e-14 52.2 0.0 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein TPT PF03151.16 EDK38832.2 - 7.1e-43 147.0 19.1 1.1e-42 146.4 19.1 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDK38832.2 - 7.7e-08 32.6 30.1 1.5e-06 28.4 8.4 2.8 2 2 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EDK38832.2 - 3.5e-06 26.4 18.8 4.7e-06 26.0 18.8 1.2 1 0 0 1 1 1 1 UAA transporter family Na_H_Exchanger PF00999.21 EDK38833.2 - 4.6e-69 233.1 37.9 5.9e-69 232.7 37.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Ndc1_Nup PF09531.10 EDK38834.2 - 3.9e-103 346.3 15.4 4.4e-103 346.1 15.4 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup MRP-S26 PF14943.6 EDK38835.2 - 0.0079 16.1 5.1 0.0079 16.1 5.1 2.4 1 1 1 2 2 2 1 Mitochondrial ribosome subunit S26 ERCC4 PF02732.15 EDK38836.2 - 1.9e-22 80.1 0.1 4.6e-22 78.9 0.1 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 EDK38836.2 - 0.0011 19.3 0.0 0.0096 16.3 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain HTH_45 PF14947.6 EDK38836.2 - 0.013 15.4 0.1 0.05 13.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix FeoB_Cyto PF17910.1 EDK38836.2 - 0.055 14.0 0.0 0.15 12.7 0.0 1.7 1 0 0 1 1 1 0 FeoB cytosolic helical domain LSM PF01423.22 EDK38837.2 - 1.7e-17 62.8 0.1 2e-17 62.6 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDK38837.2 - 0.00062 19.4 0.1 0.00096 18.7 0.1 1.4 1 0 0 1 1 1 1 Hfq protein DUF150_C PF17384.2 EDK38837.2 - 0.034 14.3 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain Rad52_Rad22 PF04098.15 EDK38839.2 - 1.6e-57 193.7 0.0 2.4e-57 193.1 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein ThiF PF00899.21 EDK38840.2 - 1.6e-43 148.9 0.0 2e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EDK38840.2 - 1.3e-26 92.6 0.1 2.1e-26 91.8 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain UBA_e1_thiolCys PF10585.9 EDK38840.2 - 0.00014 21.9 0.7 0.006 16.5 0.0 2.2 1 1 1 2 2 2 1 Ubiquitin-activating enzyme active site Ecm33 PF12454.8 EDK38840.2 - 0.031 14.4 1.2 0.059 13.5 1.2 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Abhydrolase_1 PF00561.20 EDK38841.2 - 1.4e-16 60.9 0.2 2.4e-16 60.1 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK38841.2 - 3.4e-13 50.7 0.4 4.7e-13 50.3 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK38841.2 - 9.3e-10 38.2 0.1 1.9e-09 37.1 0.1 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EDK38841.2 - 0.0024 17.7 0.0 0.0044 16.9 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase MRJP PF03022.16 EDK38842.2 - 2.8e-27 95.8 0.0 4.4e-27 95.2 0.0 1.3 1 1 0 1 1 1 1 Major royal jelly protein Cu-oxidase_2 PF07731.14 EDK38843.2 - 4.5e-45 152.8 9.2 6e-41 139.4 0.7 3.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDK38843.2 - 2.2e-41 140.6 5.3 4.5e-39 133.1 0.4 3.4 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EDK38843.2 - 1.8e-39 135.4 7.9 1.9e-34 119.1 1.2 3.3 3 1 0 3 3 3 2 Multicopper oxidase Adap_comp_sub PF00928.21 EDK38844.2 - 5.1e-37 127.7 0.0 1.9e-30 106.1 0.0 2.2 2 0 0 2 2 2 2 Adaptor complexes medium subunit family DPM2 PF07297.12 EDK38845.1 - 1.6e-32 111.6 2.6 1.8e-32 111.4 2.6 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EDK38845.1 - 0.012 15.5 0.2 0.013 15.4 0.2 1.1 1 0 0 1 1 1 0 PIG-P Phage_holin_3_6 PF07332.11 EDK38845.1 - 0.015 15.3 1.5 0.016 15.3 1.5 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III MerE PF05052.12 EDK38845.1 - 0.021 14.7 0.9 0.06 13.3 0.1 1.9 2 0 0 2 2 2 0 MerE protein Lgl_C PF08596.10 EDK38846.2 - 3.7e-118 394.7 0.0 6e-118 394.0 0.0 1.3 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EDK38846.2 - 9e-06 25.9 0.0 0.97 9.8 0.0 5.6 6 1 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK38846.2 - 0.069 14.0 3.9 2.5 9.1 0.0 4.9 6 0 0 6 6 6 0 WD domain, G-beta repeat tRNA-synt_2b PF00587.25 EDK38847.2 - 3.5e-26 92.3 0.0 7.3e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDK38847.2 - 2.7e-08 34.0 7.6 2.7e-08 34.0 7.6 1.6 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 EDK38847.2 - 0.33 9.5 6.7 0.92 8.0 6.1 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A AA_permease PF00324.21 EDK38848.2 - 1.6e-124 416.1 33.3 2e-124 415.8 33.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK38848.2 - 1.9e-29 102.8 35.6 2.3e-29 102.5 35.6 1.0 1 0 0 1 1 1 1 Amino acid permease HemY_N PF07219.13 EDK38848.2 - 0.92 9.7 5.1 20 5.4 0.6 3.2 3 0 0 3 3 3 0 HemY protein N-terminus Nramp PF01566.18 EDK38848.2 - 3.7 6.4 17.9 0.017 14.1 2.6 3.3 4 0 0 4 4 4 0 Natural resistance-associated macrophage protein Peptidase_M3 PF01432.20 EDK38849.2 - 1e-110 371.2 2.3 1.3e-110 370.8 2.3 1.1 1 0 0 1 1 1 1 Peptidase family M3 FAM184 PF15665.5 EDK38849.2 - 0.015 15.1 1.4 0.017 14.9 0.2 1.7 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Apo-CIII PF05778.12 EDK38849.2 - 0.031 13.9 0.3 5.2 6.8 0.2 2.8 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) Peptidase_M50B PF13398.6 EDK38849.2 - 0.15 11.7 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Pkinase PF00069.25 EDK38850.2 - 1.3e-64 218.1 0.0 2e-64 217.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38850.2 - 2.8e-33 115.3 0.0 2.8e-21 76.0 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK38850.2 - 2.3e-06 26.8 0.2 5.1e-06 25.7 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDK38850.2 - 4.1e-06 26.3 0.1 0.017 14.5 0.0 3.3 3 0 0 3 3 3 2 Kinase-like RskA PF10099.9 EDK38850.2 - 0.018 15.4 7.2 0.018 15.4 7.2 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TFIIA PF03153.13 EDK38850.2 - 0.029 14.4 8.3 0.0085 16.1 5.6 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Kdo PF06293.14 EDK38850.2 - 0.15 11.4 0.0 0.41 10.0 0.0 1.6 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cid2 PF09774.9 EDK38851.1 - 2.2e-33 115.9 6.1 1.1e-32 113.7 6.1 1.8 1 1 0 1 1 1 1 Caffeine-induced death protein 2 FAD_binding_3 PF01494.19 EDK38851.1 - 0.18 11.0 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain TPR_1 PF00515.28 EDK38852.2 - 4.7e-08 32.5 0.0 0.066 13.1 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38852.2 - 6.7e-05 22.7 0.0 1.2 9.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38852.2 - 0.0057 16.9 2.8 1.2 9.5 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDK38852.2 - 0.015 14.7 0.0 2.3 7.7 0.0 2.8 3 0 0 3 3 3 0 SHNi-TPR Snf7 PF03357.21 EDK38853.2 - 3.3e-11 43.1 18.4 5.3e-11 42.4 18.3 1.4 1 1 0 1 1 1 1 Snf7 FKBP_C PF00254.28 EDK38853.2 - 0.063 13.6 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase FAM117 PF15388.6 EDK38853.2 - 0.1 12.0 0.6 0.14 11.6 0.6 1.2 1 0 0 1 1 1 0 Protein Family FAM117 Ist1 PF03398.14 EDK38853.2 - 0.19 11.7 6.0 0.35 10.8 6.0 1.4 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway PspA_IM30 PF04012.12 EDK38853.2 - 0.65 9.5 15.6 41 3.6 15.6 2.2 1 1 0 1 1 1 0 PspA/IM30 family DUF3886 PF13025.6 EDK38853.2 - 0.72 10.1 9.2 0.76 10.0 6.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) DUF948 PF06103.11 EDK38853.2 - 2 8.7 8.4 0.29 11.4 1.5 2.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2543 PF10820.8 EDK38853.2 - 2.6 8.3 6.9 8.5 6.6 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2543) Sod_Fe_C PF02777.18 EDK38854.1 - 6.2e-33 113.0 0.8 6.2e-33 113.0 0.8 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDK38854.1 - 2.4e-29 101.6 1.2 4.3e-29 100.8 1.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.7 EDK38854.1 - 0.024 14.7 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Vps5 PF09325.10 EDK38856.1 - 1.7e-07 31.0 12.2 1e-06 28.5 12.2 1.9 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EDK38856.1 - 0.00041 20.3 3.0 0.0053 16.7 0.0 2.7 2 1 0 2 2 2 1 PX domain Trypan_PARP PF05887.11 EDK38856.1 - 3 7.8 9.7 5.2 7.1 9.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Mito_carr PF00153.27 EDK38857.2 - 7.3e-10 38.6 0.0 0.0034 17.3 0.0 3.3 3 1 0 3 3 3 2 Mitochondrial carrier protein Syntaxin-6_N PF09177.11 EDK38858.2 - 3.3e-10 40.4 5.8 7.9e-10 39.2 1.6 2.9 2 2 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EDK38858.2 - 0.00045 20.2 1.2 0.0011 18.9 1.2 1.7 1 0 0 1 1 1 1 SNARE domain DUF1640 PF07798.11 EDK38858.2 - 0.2 11.7 9.0 0.83 9.7 9.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Sec20 PF03908.13 EDK38858.2 - 0.46 10.4 3.0 4.9 7.1 0.2 2.4 2 0 0 2 2 2 0 Sec20 NPV_P10 PF05531.12 EDK38858.2 - 6.1 7.4 9.7 4.6 7.8 0.8 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 EDK38858.2 - 9.5 6.8 12.9 1.1 9.8 3.4 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 TBCC_N PF16752.5 EDK38859.2 - 0.13 12.7 0.4 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain TFIID-18kDa PF02269.16 EDK38860.2 - 7.9e-34 115.6 1.7 1e-33 115.2 0.2 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 EDK38860.2 - 0.21 11.7 2.8 0.38 10.9 1.0 2.4 2 1 0 2 2 2 0 hTAFII28-like protein conserved region Acetyltransf_1 PF00583.25 EDK38861.1 - 1.9e-13 50.6 0.0 2.6e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK38861.1 - 5.4e-08 32.8 0.1 7.1e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK38861.1 - 1.6e-05 25.2 0.0 2.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDK38861.1 - 3.2e-05 24.0 0.1 7.4e-05 22.8 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK38861.1 - 3.7e-05 23.6 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 EDK38861.1 - 0.0045 16.5 0.4 0.0094 15.4 0.2 1.6 2 0 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 EDK38861.1 - 0.0062 17.2 0.0 0.0092 16.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4984 PF16372.5 EDK38861.1 - 0.086 12.8 1.9 0.16 11.9 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4984) KH_8 PF17903.1 EDK38862.2 - 1.8e-08 34.3 0.0 3.5e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDK38862.2 - 0.081 12.8 0.2 0.18 11.7 0.2 1.5 1 0 0 1 1 1 0 KH domain MDM31_MDM32 PF08118.11 EDK38863.2 - 7.9e-104 348.2 0.7 4.4e-76 256.6 1.1 2.0 1 1 1 2 2 2 2 Yeast mitochondrial distribution and morphology (MDM) proteins G-patch_2 PF12656.7 EDK38864.2 - 8.1e-19 67.5 1.2 1.9e-18 66.3 0.2 2.0 2 0 0 2 2 2 1 G-patch domain AAA PF00004.29 EDK38865.2 - 2.6e-07 31.1 0.0 6.6e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDK38865.2 - 0.0014 18.6 0.1 0.13 12.2 0.0 3.5 2 1 0 2 2 2 1 Rad17 P-loop domain VirE PF05272.11 EDK38865.2 - 0.0097 15.6 0.1 0.77 9.5 0.1 2.3 2 0 0 2 2 2 1 Virulence-associated protein E HUN PF08729.10 EDK38865.2 - 0.016 15.2 3.2 0.079 13.0 3.2 2.2 1 0 0 1 1 1 0 HPC2 and ubinuclein domain AAA_16 PF13191.6 EDK38865.2 - 0.036 14.5 0.0 0.08 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TRAPP PF04051.16 EDK38866.2 - 9.6e-43 145.4 0.0 1.2e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Hid1 PF12722.7 EDK38867.2 - 8.1 4.4 9.4 9.5 4.2 9.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CAF20 PF17052.5 EDK38868.2 - 0.064 13.4 0.6 0.15 12.2 0.6 1.6 1 0 0 1 1 1 0 Cap associated factor Y_phosphatase PF00102.27 EDK38869.2 - 6.4e-61 205.9 0.0 9.5e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EDK38869.2 - 4.8e-11 43.1 0.0 1.6e-10 41.4 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EDK38869.2 - 0.00055 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDK38869.2 - 0.048 13.6 0.1 0.091 12.7 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Thioredoxin PF00085.20 EDK38870.1 - 1.4e-29 102.1 0.0 1.6e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDK38870.1 - 8.3e-08 32.5 0.0 0.00012 22.3 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDK38870.1 - 6.9e-06 26.5 0.1 3.3e-05 24.3 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EDK38870.1 - 0.00011 22.0 0.0 0.00013 21.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EDK38870.1 - 0.00016 20.7 0.0 0.00018 20.6 0.0 1.0 1 0 0 1 1 1 1 Phosducin Glutaredoxin PF00462.24 EDK38870.1 - 0.00022 21.4 0.1 0.00045 20.4 0.0 1.5 2 0 0 2 2 2 1 Glutaredoxin TraF PF13728.6 EDK38870.1 - 0.00056 19.8 0.0 0.00066 19.6 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EDK38870.1 - 0.001 19.0 0.0 0.0014 18.6 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK38870.1 - 0.0038 16.9 0.1 0.0058 16.4 0.1 1.6 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 EDK38870.1 - 0.015 15.2 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EDK38870.1 - 0.016 15.4 0.1 0.025 14.8 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like OST3_OST6 PF04756.13 EDK38870.1 - 0.017 14.5 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family PCYCGC PF13798.6 EDK38870.1 - 0.053 13.4 0.0 0.059 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif DIM1 PF02966.16 EDK38870.1 - 0.09 12.6 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 SET PF00856.28 EDK38871.2 - 0.028 14.8 0.0 0.053 13.9 0.0 1.5 1 0 0 1 1 1 0 SET domain eIF3_subunit PF08597.10 EDK38872.2 - 8.2e-59 199.4 25.4 1e-58 199.1 25.4 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Ago_hook PF10427.9 EDK38872.2 - 0.011 16.3 2.9 0.017 15.7 2.9 1.3 1 0 0 1 1 1 0 Argonaute hook PI3K_1B_p101 PF10486.9 EDK38872.2 - 0.022 12.6 5.8 0.03 12.1 5.8 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Lipase_GDSL_3 PF14606.6 EDK38872.2 - 0.082 13.0 1.7 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Rrn6 PF10214.9 EDK38872.2 - 0.14 10.6 5.8 0.26 9.7 5.8 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Jak1_Phl PF17887.1 EDK38872.2 - 1.8 8.5 6.7 0.77 9.7 3.6 1.8 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain 3HCDH_N PF02737.18 EDK38872.2 - 9.5 6.1 7.1 28 4.5 7.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain His_Phos_1 PF00300.22 EDK38873.1 - 9e-10 38.6 0.1 5.5e-09 36.0 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Dynactin_p62 PF05502.13 EDK38874.2 - 6.6e-06 25.2 18.6 0.014 14.2 0.3 2.7 2 1 0 2 2 2 2 Dynactin p62 family RNA_POL_M_15KD PF02150.16 EDK38874.2 - 0.31 10.9 0.2 0.31 10.9 0.2 3.7 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit SET PF00856.28 EDK38874.2 - 6.7 7.1 7.3 21 5.5 7.3 1.9 1 1 0 1 1 1 0 SET domain FAD-oxidase_C PF02913.19 EDK38875.2 - 5.5e-57 193.3 0.0 9e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDK38875.2 - 1.6e-36 125.1 0.0 3.6e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain SGTA_dimer PF16546.5 EDK38876.2 - 1e-24 86.0 2.5 2.2e-24 85.0 2.5 1.6 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EDK38876.2 - 5.2e-13 48.2 2.9 0.00028 20.6 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38876.2 - 7.2e-11 41.3 5.1 0.012 15.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDK38876.2 - 8.3e-10 38.2 5.7 5.3e-05 22.8 1.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 EDK38876.2 - 3.4e-06 26.8 8.4 0.027 14.7 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK38876.2 - 4.4e-06 26.7 1.2 0.021 15.2 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat STI1 PF17830.1 EDK38876.2 - 9e-06 25.5 7.0 9e-06 25.5 7.0 2.4 1 1 0 2 2 2 1 STI1 domain TPR_7 PF13176.6 EDK38876.2 - 0.00014 21.6 1.0 7.3 6.9 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK38876.2 - 0.00015 22.0 4.3 0.011 16.1 1.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK38876.2 - 0.00022 21.8 4.0 0.85 10.6 0.0 3.9 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDK38876.2 - 0.00061 19.6 4.7 0.019 14.8 0.2 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat SurA_N_2 PF13623.6 EDK38876.2 - 0.0053 16.6 1.5 0.08 12.8 0.3 2.5 2 0 0 2 2 2 1 SurA N-terminal domain TPR_16 PF13432.6 EDK38876.2 - 0.0071 17.0 6.7 0.025 15.2 2.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat E3_binding PF02817.17 EDK38876.2 - 0.066 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 e3 binding domain BTAD PF03704.17 EDK38876.2 - 0.21 12.0 2.6 0.6 10.5 0.2 2.6 1 1 2 3 3 3 0 Bacterial transcriptional activator domain MIT PF04212.18 EDK38876.2 - 0.42 10.7 5.4 4.1 7.5 0.0 3.6 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 EDK38876.2 - 0.91 10.1 7.1 0.86 10.2 0.8 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDK38876.2 - 8.1 7.3 7.5 10 7.0 0.8 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat VPS9 PF02204.18 EDK38877.2 - 2.4e-10 40.5 0.8 6.4e-10 39.2 0.8 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EDK38877.2 - 6.7e-05 23.1 0.1 0.038 14.3 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) FAM220 PF15487.6 EDK38877.2 - 0.00097 18.8 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 FAM220 family Ank_2 PF12796.7 EDK38877.2 - 0.0018 18.8 4.6 0.063 13.9 0.1 3.8 2 1 3 5 5 5 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDK38877.2 - 0.0072 16.7 0.2 0.21 12.3 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EDK38877.2 - 0.031 14.9 0.4 7.2 7.3 0.0 3.5 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 EDK38877.2 - 0.14 12.6 0.0 5.9 7.5 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat Hydantoinase_B PF02538.14 EDK38878.2 - 8.2e-192 638.2 0.1 1e-191 637.9 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_B PF02538.14 EDK38880.1 - 1.2e-07 30.6 0.0 1.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDK38881.2 - 7.8e-82 274.8 0.2 9.6e-82 274.5 0.2 1.0 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase HMG-CoA_red PF00368.18 EDK38881.2 - 0.097 11.7 1.1 0.14 11.1 0.0 1.7 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A reductase Ribo_biogen_C PF04034.13 EDK38882.1 - 6.2e-52 174.6 0.0 9.2e-52 174.1 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EDK38882.1 - 1.3e-16 60.1 0.4 2.2e-16 59.4 0.4 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Ribonuc_red_sm PF00268.21 EDK38883.1 - 2.1e-123 411.2 1.2 3e-123 410.7 1.2 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain RE_XcyI PF09571.10 EDK38883.1 - 0.055 12.7 0.1 0.55 9.4 0.1 2.0 2 0 0 2 2 2 0 XcyI restriction endonuclease DUF4744 PF15918.5 EDK38883.1 - 0.14 13.0 0.0 0.33 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) RNA_pol_Rpb5_C PF01191.19 EDK38883.1 - 0.16 11.9 0.1 0.38 10.6 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain PH PF00169.29 EDK38884.2 - 0.067 13.7 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 PH domain DNA_ligase_A_M PF01068.21 EDK38885.2 - 5.5e-56 189.4 0.1 9.2e-56 188.7 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDK38885.2 - 1.7e-20 74.1 0.1 4.2e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 EDK38885.2 - 1.3e-18 67.2 0.2 3.7e-08 33.7 0.0 3.2 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EDK38885.2 - 2e-13 51.0 0.1 4.2e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 EDK38885.2 - 7.6e-08 32.9 0.0 1.7e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.19 EDK38885.2 - 1.9e-05 24.6 0.5 0.25 11.1 0.0 3.2 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain BRCT PF00533.26 EDK38885.2 - 0.00066 20.0 0.1 3.2 8.2 0.0 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain Abhydrolase_6 PF12697.7 EDK38886.2 - 1.8e-10 41.8 0.6 2.4e-10 41.4 0.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK38886.2 - 0.00066 19.0 0.0 0.005 16.1 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK38886.2 - 0.0009 19.0 1.4 0.0019 17.9 1.4 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Sugar_tr PF00083.24 EDK38887.2 - 2.3e-70 237.7 23.7 1e-68 232.3 23.7 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK38887.2 - 4.6e-36 124.5 37.7 9.2e-32 110.3 20.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EDK38887.2 - 1.4e-05 23.6 0.5 1.4e-05 23.6 0.5 2.3 2 1 1 3 3 3 1 BT1 family MFS_4 PF06779.14 EDK38887.2 - 0.00027 20.4 15.9 0.00027 20.4 15.9 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB PI-PLC-X PF00388.19 EDK38888.2 - 3.1e-19 69.0 0.0 5.1e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF697 PF05128.12 EDK38888.2 - 0.056 13.1 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF697) She9_MDM33 PF05546.11 EDK38889.2 - 9.1e-88 293.2 9.8 9.1e-88 293.2 9.8 1.6 2 0 0 2 2 2 1 She9 / Mdm33 family zf-RING_9 PF13901.6 EDK38889.2 - 0.00046 20.2 4.4 0.0047 16.9 0.7 2.2 1 1 1 2 2 2 2 Putative zinc-RING and/or ribbon PsbH PF00737.20 EDK38889.2 - 0.036 13.8 0.4 0.072 12.8 0.4 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein Rx_N PF18052.1 EDK38889.2 - 0.091 13.0 1.4 0.19 12.0 0.2 2.3 2 1 0 2 2 2 0 Rx N-terminal domain YscO PF07321.12 EDK38889.2 - 0.5 10.3 8.9 1.3 9.0 6.9 2.3 1 1 1 2 2 2 0 Type III secretion protein YscO AAA PF00004.29 EDK38890.1 - 1.2e-45 155.2 0.0 2.8e-45 154.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDK38890.1 - 1.4e-10 41.0 0.4 8.2e-10 38.5 0.1 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDK38890.1 - 7.3e-09 36.0 0.0 1.3e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDK38890.1 - 3.9e-08 33.9 0.2 2.3e-05 24.9 0.0 3.1 1 1 2 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EDK38890.1 - 4.9e-07 29.8 0.1 1.8e-06 28.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK38890.1 - 5.2e-05 23.5 0.6 0.0055 17.0 0.6 2.6 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDK38890.1 - 8.9e-05 21.8 0.0 0.00019 20.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 EDK38890.1 - 0.00025 20.8 0.0 0.0006 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EDK38890.1 - 0.00042 20.4 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDK38890.1 - 0.00047 19.9 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDK38890.1 - 0.0016 19.0 0.0 0.0085 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EDK38890.1 - 0.0019 18.1 0.0 0.0084 16.0 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_7 PF12775.7 EDK38890.1 - 0.0021 17.6 0.1 0.015 14.8 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EDK38890.1 - 0.0027 17.9 0.0 0.0068 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDK38890.1 - 0.0048 16.7 0.0 0.023 14.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDK38890.1 - 0.0052 16.5 0.4 0.022 14.5 0.0 2.4 3 1 0 3 3 3 1 AAA domain TsaE PF02367.17 EDK38890.1 - 0.0062 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EDK38890.1 - 0.0062 16.9 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 EDK38890.1 - 0.0087 16.0 0.2 0.13 12.2 0.0 2.3 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 EDK38890.1 - 0.0094 15.3 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EDK38890.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain TniB PF05621.11 EDK38890.1 - 0.011 15.2 0.0 0.53 9.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 EDK38890.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDK38890.1 - 0.016 14.9 0.1 0.14 11.9 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.6 EDK38890.1 - 0.017 15.3 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EDK38890.1 - 0.019 15.3 0.0 0.45 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDK38890.1 - 0.024 14.4 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 EDK38890.1 - 0.036 14.0 0.1 0.36 10.7 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EDK38890.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 EDK38890.1 - 0.091 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 EDK38890.1 - 0.21 10.6 0.0 0.36 9.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EDK38890.1 - 0.26 10.9 2.1 0.4 10.2 0.1 2.2 2 1 1 3 3 3 0 AAA domain Glyco_transf_22 PF03901.17 EDK38891.2 - 1.8e-66 225.1 24.4 2.4e-66 224.7 24.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2628 PF10947.8 EDK38891.2 - 1.4 9.3 5.2 0.4 11.1 0.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) Utp12 PF04003.12 EDK38892.2 - 6e-24 84.4 0.8 1.3e-23 83.4 0.8 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family FolB PF02152.18 EDK38892.2 - 0.2 12.2 1.6 1.2 9.7 0.2 2.8 2 1 1 3 3 3 0 Dihydroneopterin aldolase Cwf_Cwc_15 PF04889.12 EDK38892.2 - 5.7 6.6 15.5 0.056 13.2 0.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_1 PF00561.20 EDK38893.2 - 7.7e-21 74.9 0.1 2.4e-19 70.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK38893.2 - 9e-14 52.6 0.0 1.3e-13 52.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK38893.2 - 8e-10 38.4 0.0 1.2e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDK38893.2 - 3.2e-08 34.0 0.0 4.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EDK38893.2 - 1.9e-05 24.5 0.3 0.0037 17.0 0.3 2.2 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 EDK38893.2 - 0.00063 19.5 0.0 0.00089 19.0 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydro_lipase PF04083.16 EDK38893.2 - 0.058 13.0 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Lipase_3 PF01764.25 EDK38893.2 - 0.068 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase2 PF12740.7 EDK38893.2 - 0.11 11.4 0.2 0.18 10.7 0.0 1.4 2 0 0 2 2 2 0 Chlorophyllase enzyme DUF3530 PF12048.8 EDK38893.2 - 0.14 11.5 0.1 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Ndr PF03096.14 EDK38893.2 - 0.16 10.6 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Ndr family CBFD_NFYB_HMF PF00808.23 EDK38894.2 - 3.2e-13 49.7 1.8 5.1e-13 49.1 1.8 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK38894.2 - 0.00051 20.4 0.6 0.0012 19.2 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 YolD PF08863.10 EDK38894.2 - 0.036 14.1 1.9 0.074 13.1 1.9 1.5 1 0 0 1 1 1 0 YolD-like protein ALMT PF11744.8 EDK38894.2 - 0.26 10.1 3.1 0.31 9.8 3.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Orthopox_B11R PF07033.11 EDK38894.2 - 1.5 8.6 6.5 0.23 11.2 1.5 2.2 2 2 0 2 2 2 0 Orthopoxvirus B11R protein Yos1 PF08571.10 EDK38895.1 - 4.4e-32 110.2 0.7 5.1e-32 110.0 0.7 1.0 1 0 0 1 1 1 1 Yos1-like RabGAP-TBC PF00566.18 EDK38896.2 - 1.5e-35 122.8 0.1 1.9e-35 122.4 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HSP70 PF00012.20 EDK38897.2 - 1.2e-50 172.3 0.1 1.2e-50 172.3 0.1 3.1 3 0 0 3 3 3 2 Hsp70 protein BSP_II PF05432.11 EDK38897.2 - 0.028 14.1 16.2 0.4 10.3 7.2 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Pribosyltran PF00156.27 EDK38898.1 - 1.9e-09 37.3 0.0 3.5e-09 36.4 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Fe-ADH PF00465.19 EDK38898.1 - 0.031 13.1 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Mito_fiss_Elm1 PF06258.11 EDK38898.1 - 0.056 12.6 0.0 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial fission ELM1 DUF2141 PF09912.9 EDK38898.1 - 0.087 12.8 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) UFD1 PF03152.14 EDK38899.2 - 2.7e-70 235.3 0.0 3.4e-70 235.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Cse1 PF08506.10 EDK38901.2 - 8.2e-12 44.6 3.0 8.2e-12 44.6 3.0 2.4 3 0 0 3 3 3 1 Cse1 DUF2115 PF09888.9 EDK38901.2 - 0.13 12.8 0.0 0.57 10.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) IBN_N PF03810.19 EDK38902.2 - 1.5e-12 47.3 0.3 4.1e-12 45.8 0.0 1.9 2 1 0 2 2 2 1 Importin-beta N-terminal domain RRM_Rrp7 PF17799.1 EDK38903.2 - 4.9e-59 198.7 0.3 1.3e-58 197.4 0.1 1.8 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 EDK38903.2 - 1.7e-29 102.4 11.5 2.4e-29 101.9 11.5 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 EDK38903.2 - 0.045 13.6 1.7 9.9 6.1 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF45 PF01863.17 EDK38903.2 - 0.22 11.6 2.8 0.37 10.8 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 Aminotran_4 PF01063.19 EDK38904.2 - 1.3e-29 103.6 0.0 1.7e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV HAD PF12710.7 EDK38905.1 - 4.8e-18 66.2 0.0 7.8e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK38905.1 - 5.5e-18 66.0 0.7 9.6e-18 65.2 0.7 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK38905.1 - 2.3e-12 47.2 0.8 9.8e-10 38.6 0.0 3.4 3 1 1 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDK38905.1 - 0.00039 20.5 1.4 0.0051 16.9 1.4 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EDK38905.1 - 0.0005 19.5 0.1 0.15 11.4 0.0 2.3 2 0 0 2 2 2 2 Putative Phosphatase DUF705 PF05152.12 EDK38905.1 - 0.032 13.7 0.2 0.055 12.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF705) CRAL_TRIO PF00650.20 EDK38906.2 - 2e-36 125.1 0.0 3e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK38906.2 - 1.1e-15 57.5 0.3 2.3e-15 56.5 0.3 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Tctex-1 PF03645.13 EDK38907.2 - 1.5e-07 31.6 0.1 4.4e-07 30.1 0.1 1.8 1 0 0 1 1 1 1 Tctex-1 family CENP-Q PF13094.6 EDK38908.2 - 1.4e-25 90.5 8.5 2.7e-25 89.5 8.5 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.9 EDK38908.2 - 0.063 13.6 7.7 0.66 10.3 4.4 2.9 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CwsA PF10814.8 EDK38908.2 - 0.2 11.8 0.2 0.52 10.5 0.1 1.8 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA E2F_CC-MB PF16421.5 EDK38908.2 - 0.87 10.0 7.2 0.28 11.6 0.9 2.7 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain zf-RRN7 PF11781.8 EDK38909.2 - 6.3e-10 38.6 0.4 1.1e-09 37.8 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Aldedh PF00171.22 EDK38910.1 - 1.1e-182 607.7 0.5 1.2e-182 607.5 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDK38910.1 - 0.042 13.3 0.2 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) CUE PF02845.16 EDK38910.1 - 0.51 10.1 2.0 4.2 7.2 0.4 2.4 2 0 0 2 2 2 0 CUE domain Sec6 PF06046.13 EDK38911.2 - 3.3e-194 646.5 15.5 5e-194 645.9 15.5 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 DASH_Dam1 PF08653.10 EDK38911.2 - 0.017 14.9 0.4 0.06 13.2 0.4 2.0 1 0 0 1 1 1 0 DASH complex subunit Dam1 Coatamer_beta_C PF07718.12 EDK38911.2 - 0.052 13.4 2.5 0.17 11.8 2.5 1.9 1 0 0 1 1 1 0 Coatomer beta C-terminal region Cnd1 PF12717.7 EDK38911.2 - 1.3 9.0 5.4 0.44 10.6 0.5 2.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 LsmAD PF06741.13 EDK38912.2 - 2.6e-28 98.4 1.2 8.5e-28 96.7 1.2 2.0 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 EDK38912.2 - 8.9e-10 38.6 0.0 2.6e-09 37.1 0.0 1.9 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.15 EDK38912.2 - 0.17 11.6 1.6 0.63 9.9 1.6 2.0 1 0 0 1 1 1 0 Ataxin-2 C-terminal region DUF4573 PF15140.6 EDK38913.2 - 0.044 13.6 0.0 0.26 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4573) ATG16 PF08614.11 EDK38914.1 - 5.6e-15 56.1 19.5 5.6e-15 56.1 19.5 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) CC2-LZ PF16516.5 EDK38914.1 - 0.0035 17.7 8.5 0.0035 17.7 8.5 2.3 1 1 1 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Lebercilin PF15619.6 EDK38914.1 - 0.0038 16.9 18.6 0.0049 16.5 10.1 2.4 1 1 1 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.15 EDK38914.1 - 0.0041 17.6 14.0 0.0058 17.1 14.0 1.2 1 0 0 1 1 1 1 Fez1 HAP1_N PF04849.13 EDK38914.1 - 0.0058 15.9 14.7 0.0091 15.2 14.7 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Cep57_MT_bd PF06657.13 EDK38914.1 - 0.014 15.8 9.2 0.057 13.9 0.5 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Flagellar_rod PF05149.12 EDK38914.1 - 0.021 14.3 11.3 0.029 13.8 11.3 1.3 1 0 0 1 1 1 0 Paraflagellar rod protein Spc7 PF08317.11 EDK38914.1 - 0.023 13.6 13.9 0.029 13.3 13.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TRAF_BIRC3_bd PF16673.5 EDK38914.1 - 0.025 14.4 2.6 0.025 14.4 2.6 2.1 2 1 1 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain HrpB7 PF09486.10 EDK38914.1 - 0.062 13.7 1.0 0.062 13.7 1.0 2.3 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) UPF0242 PF06785.11 EDK38914.1 - 0.086 12.9 14.2 0.14 12.3 14.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 EDK38914.1 - 0.18 11.4 8.1 0.19 11.2 8.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EDK38914.1 - 0.18 10.9 13.5 0.43 9.6 13.5 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cut12 PF11500.8 EDK38914.1 - 0.23 11.4 10.1 0.036 14.0 3.8 2.0 2 0 0 2 2 2 0 Spindle pole body formation-associated protein SlyX PF04102.12 EDK38914.1 - 0.25 12.0 12.6 0.71 10.5 1.5 2.7 1 1 1 2 2 2 0 SlyX Mod_r PF07200.13 EDK38914.1 - 0.26 11.4 14.0 0.48 10.5 14.0 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein TMPIT PF07851.13 EDK38914.1 - 0.42 9.8 8.3 0.62 9.3 8.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.9 EDK38914.1 - 0.43 10.8 15.1 0.44 10.7 13.7 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 EDK38914.1 - 0.49 10.5 16.2 0.29 11.2 13.6 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Val_tRNA-synt_C PF10458.9 EDK38914.1 - 0.6 10.4 13.2 5.3 7.4 1.0 3.5 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm OEP PF02321.18 EDK38914.1 - 0.61 9.9 10.3 0.79 9.5 9.7 1.5 1 1 0 1 1 1 0 Outer membrane efflux protein DUF3394 PF11874.8 EDK38914.1 - 0.63 9.7 4.3 0.67 9.6 2.9 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3394) SLIDE PF09111.10 EDK38914.1 - 0.68 10.0 8.9 1.5 8.9 6.7 2.1 1 1 1 2 2 2 0 SLIDE TMF_DNA_bd PF12329.8 EDK38914.1 - 0.75 9.8 19.5 4.5 7.3 12.0 2.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ABC_tran_CTD PF16326.5 EDK38914.1 - 1.4 9.2 13.3 22 5.4 9.8 2.7 2 1 0 2 2 1 0 ABC transporter C-terminal domain APG6_N PF17675.1 EDK38914.1 - 1.4 9.4 18.2 0.47 11.0 10.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region zf-CRD PF17979.1 EDK38914.1 - 1.5 8.9 3.4 1.9 8.6 3.1 1.3 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions CENP-H PF05837.12 EDK38914.1 - 1.6 9.2 16.1 1 9.8 12.1 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF16 PF01519.16 EDK38914.1 - 2.7 8.5 14.1 3.7 8.1 7.3 2.3 1 1 0 2 2 2 0 Protein of unknown function DUF16 Occludin_ELL PF07303.13 EDK38914.1 - 2.9 8.7 8.3 3 8.6 4.6 2.2 1 1 1 2 2 2 0 Occludin homology domain PRKG1_interact PF15898.5 EDK38914.1 - 3.2 8.7 16.7 14 6.6 16.2 2.1 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF641 PF04859.12 EDK38914.1 - 4.2 7.7 12.3 0.71 10.2 2.1 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FAM76 PF16046.5 EDK38914.1 - 4.9 6.4 14.7 3.1 7.1 12.7 1.6 1 1 1 2 2 2 0 FAM76 protein FlxA PF14282.6 EDK38914.1 - 5.7 7.0 15.0 20 5.3 15.1 1.9 1 1 0 1 1 1 0 FlxA-like protein DUF948 PF06103.11 EDK38914.1 - 8.5 6.7 9.8 22 5.4 0.6 2.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) GPS2_interact PF15784.5 EDK38914.1 - 8.7 6.9 13.6 5.6 7.5 7.8 2.4 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain Glyco_transf_22 PF03901.17 EDK38915.2 - 1.4e-45 156.3 20.1 1.7e-45 156.0 20.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Peptidase_C2 PF00648.21 EDK38916.2 - 1.5e-10 40.6 0.0 2.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EDK38916.2 - 0.011 15.9 2.2 0.15 12.4 0.5 3.0 2 1 0 2 2 2 0 Calpain large subunit, domain III MHC_I_2 PF14586.6 EDK38916.2 - 0.073 12.9 1.7 0.81 9.5 0.2 2.6 3 0 0 3 3 3 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 GBS_Bsp-like PF08481.10 EDK38916.2 - 0.1 12.7 0.0 0.39 10.8 0.0 2.0 1 0 0 1 1 1 0 GBS Bsp-like repeat OST3_OST6 PF04756.13 EDK38917.2 - 4.1e-94 315.2 3.7 4.9e-94 315.0 3.7 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 EDK38917.2 - 0.078 13.0 0.1 0.88 9.6 0.1 2.2 1 1 0 1 1 1 0 Thioredoxin DUF1980 PF09323.10 EDK38917.2 - 0.085 12.8 6.5 0.1 12.5 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) SURF6 PF04935.12 EDK38918.2 - 0.049 13.4 0.7 0.052 13.3 0.7 1.4 1 1 0 1 1 1 0 Surfeit locus protein 6 RNA_pol_Rpb4 PF03874.16 EDK38919.1 - 7.1e-32 110.3 1.0 8.6e-32 110.1 1.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 LTV PF04180.14 EDK38919.1 - 0.021 14.6 0.6 0.024 14.4 0.6 1.4 1 1 0 1 1 1 0 Low temperature viability protein Ten1 PF12658.7 EDK38920.1 - 2e-21 76.2 0.0 2.5e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Fungal_trans PF04082.18 EDK38921.2 - 3.7e-24 85.2 0.3 3.7e-24 85.2 0.3 2.1 3 0 0 3 3 3 1 Fungal specific transcription factor domain DUF3080 PF11279.8 EDK38921.2 - 0.0093 15.2 0.1 0.0093 15.2 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3080) Zn_clus PF00172.18 EDK38922.2 - 1.3e-10 41.2 10.1 2e-10 40.6 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM153 PF15722.5 EDK38924.2 - 0.065 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 FAM153 family SPRY PF00622.28 EDK38925.2 - 0.00024 21.2 0.0 0.013 15.6 0.0 2.6 2 0 0 2 2 2 2 SPRY domain SMC_Nse1 PF07574.13 EDK38926.2 - 2.6e-17 63.3 1.1 7.1e-14 52.2 0.7 2.1 1 1 1 2 2 2 2 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EDK38926.2 - 0.00024 21.3 12.1 0.00046 20.4 12.1 1.5 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 EDK38926.2 - 0.01 16.2 6.2 0.024 14.9 6.2 1.6 1 0 0 1 1 1 0 Ring finger domain Cache_3-Cache_2 PF17201.4 EDK38926.2 - 0.015 14.6 0.3 0.021 14.1 0.3 1.1 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain Chordopox_A30L PF06015.12 EDK38926.2 - 0.022 14.5 0.2 0.022 14.5 0.2 1.7 2 0 0 2 2 2 0 Chordopoxvirus A30L protein zf-rbx1 PF12678.7 EDK38926.2 - 0.11 12.9 5.3 0.21 11.9 5.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EDK38926.2 - 0.54 9.9 11.3 1.2 8.8 11.3 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Glyco_hydro_16 PF00722.21 EDK38927.2 - 4e-40 137.2 0.0 5.8e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PFK PF00365.20 EDK38928.2 - 3.8e-184 610.5 0.4 1.9e-103 345.7 0.2 2.2 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 EDK38928.2 - 7e-36 122.6 0.0 1.4e-35 121.6 0.0 1.6 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast UVR PF02151.19 EDK38928.2 - 0.018 14.8 0.9 0.064 13.0 0.9 2.0 1 0 0 1 1 1 0 UvrB/uvrC motif DAGK_cat PF00781.24 EDK38928.2 - 0.045 13.4 0.0 0.4 10.3 0.0 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain HSF_DNA-bind PF00447.17 EDK38929.2 - 7.7e-27 93.7 0.7 1.7e-26 92.6 0.7 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding CDRT4 PF15213.6 EDK38929.2 - 0.22 12.1 0.1 0.22 12.1 0.1 2.9 3 0 0 3 3 3 0 CMT1A duplicated region transcript 4 protein NOP19 PF10863.8 EDK38930.2 - 1.4e-16 60.6 14.9 5.7e-16 58.6 7.4 3.0 2 1 0 2 2 2 1 Nucleolar protein 19 DUF3245 PF11595.8 EDK38930.2 - 0.0022 18.5 11.9 0.0035 17.8 11.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3245) DUF4953 PF16313.5 EDK38930.2 - 0.04 13.1 0.4 1.1 8.4 0.1 2.0 2 0 0 2 2 2 0 Met-zincin Got1 PF04178.12 EDK38932.1 - 1.6e-14 54.3 9.3 1.9e-14 54.1 9.3 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DnaJ_CXXCXGXG PF00684.19 EDK38933.2 - 1.5e-05 25.2 14.9 0.048 14.0 0.4 2.8 2 1 1 3 3 3 3 DnaJ central domain zinc-ribbons_6 PF07191.12 EDK38933.2 - 0.0068 16.4 6.5 0.68 10.0 0.5 3.1 3 0 0 3 3 3 2 zinc-ribbons HypA PF01155.19 EDK38933.2 - 0.1 12.7 6.5 8.6 6.4 0.5 3.1 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrome_C554 PF13435.6 EDK38933.2 - 0.14 13.1 2.8 5 8.1 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c554 and c-prime DUF2318 PF10080.9 EDK38933.2 - 0.48 10.6 12.0 0.26 11.4 0.7 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) Cytochrom_c3_2 PF14537.6 EDK38933.2 - 0.73 10.3 8.4 0.47 10.9 5.4 2.3 2 1 0 2 2 2 0 Cytochrome c3 TackOD1 PF18551.1 EDK38933.2 - 1.1 8.9 9.7 1.7 8.3 0.4 2.7 3 0 0 3 3 3 0 Thaumarchaeal output domain 1 K1377 PF15352.6 EDK38933.2 - 3.8 5.7 4.8 4.8 5.3 4.8 1.0 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Cytochrome_C7 PF14522.6 EDK38933.2 - 8.6 6.4 14.2 7.1 6.7 6.1 2.6 2 1 1 3 3 3 0 Cytochrome c7 and related cytochrome c Aldedh PF00171.22 EDK38934.2 - 2e-106 356.3 0.0 2.5e-106 356.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MMR_HSR1_Xtn PF16897.5 EDK38935.2 - 7.2e-37 125.6 0.7 1.4e-36 124.7 0.7 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EDK38935.2 - 1e-21 77.1 0.1 2.3e-21 76.0 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDK38935.2 - 8.2e-20 70.6 0.1 1.8e-19 69.5 0.1 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDK38935.2 - 3.8e-14 52.5 0.1 6.6e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDK38935.2 - 3.2e-05 24.1 1.6 0.015 15.4 0.1 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 EDK38935.2 - 0.0056 16.0 0.2 0.0093 15.3 0.2 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 EDK38935.2 - 0.072 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EDK38935.2 - 0.084 13.1 0.4 0.51 10.6 0.1 2.3 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EDK38935.2 - 0.086 11.9 0.1 0.29 10.2 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain YchF-GTPase_C PF06071.13 EDK38935.2 - 0.15 12.2 0.3 1.1 9.5 0.0 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF933) Efg1 PF10153.9 EDK38936.2 - 2.4e-36 124.6 13.3 2.4e-36 124.6 13.3 1.9 2 0 0 2 2 2 1 rRNA-processing protein Efg1 Prismane PF03063.20 EDK38936.2 - 0.21 10.3 0.9 0.27 9.9 0.9 1.2 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Cep57_CLD_2 PF14197.6 EDK38936.2 - 0.86 9.7 9.1 0.06 13.5 2.9 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Sec63 PF02889.16 EDK38937.2 - 3.7e-45 154.1 0.2 8.1e-45 153.0 0.3 1.5 2 0 0 2 2 2 1 Sec63 Brl domain Helicase_C PF00271.31 EDK38937.2 - 9.3e-09 35.6 0.0 6.5e-08 32.9 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Sec63 PF02889.16 EDK38938.2 - 2.9e-28 98.7 0.0 3.9e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EDK38938.2 - 2.6e-14 53.4 0.0 3.5e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDK38938.2 - 2.1e-11 44.2 0.0 6e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDK38938.2 - 0.0038 17.0 0.0 0.0058 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EDK38938.2 - 0.0095 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.6 EDK38938.2 - 0.12 12.7 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sec63 PF02889.16 EDK38939.2 - 4.8e-50 170.1 0.0 8.4e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EDK38939.2 - 2.9e-28 98.8 1.1 3.1e-26 92.2 0.6 4.0 4 0 0 4 4 4 1 DEAD/DEAH box helicase ResIII PF04851.15 EDK38939.2 - 1.1e-11 45.0 0.1 1.1e-11 45.0 0.1 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDK38939.2 - 5.6e-07 29.9 0.0 4.8e-06 26.9 0.0 2.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_PWI PF18149.1 EDK38939.2 - 0.00032 20.8 0.6 0.0011 19.1 0.6 1.9 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_19 PF13245.6 EDK38939.2 - 0.015 15.6 0.3 0.047 14.0 0.3 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDK38939.2 - 0.066 13.5 1.0 1.1 9.6 1.0 2.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDK38939.2 - 0.12 12.1 0.8 1.6 8.5 0.0 2.8 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF2666 PF10869.8 EDK38939.2 - 0.21 11.8 2.0 0.58 10.4 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) DEAD PF00270.29 EDK38940.2 - 2.1e-46 157.9 1.5 2.5e-46 157.7 0.1 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK38940.2 - 2.7e-24 85.6 0.0 1.1e-23 83.6 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDK38940.2 - 5.3e-17 61.8 0.2 1.3e-16 60.6 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ALMT PF11744.8 EDK38940.2 - 1.1 8.0 3.1 0.38 9.5 0.2 1.6 1 1 1 2 2 2 0 Aluminium activated malate transporter DNA_pol_E_B PF04042.16 EDK38941.2 - 9.5e-40 136.2 0.0 1.6e-39 135.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EDK38941.2 - 2e-28 99.1 0.0 5.7e-28 97.6 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase delta subunit OB-fold domain RNB PF00773.19 EDK38942.2 - 3.9e-68 230.2 0.6 1.4e-67 228.4 1.0 1.7 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 EDK38942.2 - 5e-23 80.9 0.1 1.2e-22 79.8 0.1 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EDK38942.2 - 3.4e-22 78.6 0.0 1.1e-21 76.9 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EDK38942.2 - 1.7e-06 28.1 0.0 0.00049 20.2 0.0 2.7 2 0 0 2 2 2 1 Cold shock domain Rrp44_CSD1 PF17216.3 EDK38942.2 - 0.00027 20.7 0.4 0.00071 19.3 0.4 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 EDK38942.2 - 0.0071 16.0 0.1 1.5 8.6 0.0 2.9 2 0 0 2 2 2 1 Ribonuclease B OB domain Rrp44_S1 PF17215.3 EDK38942.2 - 0.031 14.2 0.0 0.081 12.9 0.0 1.7 1 0 0 1 1 1 0 S1 domain Alpha-mann_mid PF09261.11 EDK38942.2 - 0.046 13.9 0.0 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 Alpha mannosidase middle domain GTP_cyclohydroI PF01227.22 EDK38943.1 - 1.3e-77 259.2 0.1 1.6e-77 259.0 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EDK38943.1 - 0.0002 21.5 0.0 0.001 19.1 0.0 2.0 2 0 0 2 2 2 1 QueF-like protein Amidase PF01425.21 EDK38944.2 - 3.3e-113 379.0 0.4 4.1e-113 378.7 0.4 1.0 1 0 0 1 1 1 1 Amidase AIM5 PF17050.5 EDK38944.2 - 0.031 15.1 0.0 0.077 13.8 0.0 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria 5 tRNA-synt_1g PF09334.11 EDK38945.2 - 8.3e-156 518.6 1.3 1.1e-155 518.3 1.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDK38945.2 - 5.2e-08 31.6 1.2 0.00075 17.9 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) MetRS-N PF09635.10 EDK38945.2 - 1.7e-07 31.8 0.1 3.7e-07 30.7 0.1 1.7 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1e PF01406.19 EDK38945.2 - 0.0044 16.4 0.2 0.037 13.4 0.1 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain EKLF_TAD1 PF16832.5 EDK38945.2 - 0.097 12.6 1.1 0.22 11.4 1.1 1.5 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 zf-ribbon_3 PF13248.6 EDK38945.2 - 1.6 8.3 4.2 19 4.8 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain PS_Dcarbxylase PF02666.15 EDK38946.2 - 8e-57 192.0 0.0 1.3e-56 191.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EDK38946.2 - 3.9e-23 81.7 0.5 1.6e-13 50.9 0.0 2.9 2 0 0 2 2 2 2 C2 domain SRP54 PF00448.22 EDK38947.2 - 4.2e-47 160.3 1.6 5.2e-47 160.0 0.5 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain MeaB PF03308.16 EDK38947.2 - 4.1e-08 32.5 0.0 7.6e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP-alpha_N PF04086.13 EDK38947.2 - 2.8e-07 30.7 1.6 5e-07 29.9 1.6 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal AAA_30 PF13604.6 EDK38947.2 - 0.0022 17.8 0.1 0.0087 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRX PF09201.10 EDK38947.2 - 0.0029 17.4 0.1 0.0082 16.0 0.1 1.8 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit CbiA PF01656.23 EDK38947.2 - 0.0047 17.0 0.0 0.028 14.5 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDK38947.2 - 0.0095 15.9 0.2 0.059 13.3 0.1 2.2 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDK38947.2 - 0.013 15.7 0.2 0.088 13.1 0.0 2.4 3 1 0 3 3 3 0 AAA domain SMC_N PF02463.19 EDK38947.2 - 0.65 9.4 5.4 2 7.8 0.1 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Yip1 PF04893.17 EDK38948.1 - 2.6e-10 40.3 17.0 4.2e-10 39.6 16.7 1.4 1 1 0 1 1 1 1 Yip1 domain tRNA-synt_1g PF09334.11 EDK38949.2 - 1.5e-98 330.1 0.4 5.7e-97 324.9 0.4 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDK38949.2 - 3.2e-25 88.4 0.2 1.8e-10 39.7 0.0 4.0 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDK38949.2 - 3.3e-09 36.5 0.1 0.002 17.6 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EDK38949.2 - 0.0026 17.7 0.0 0.0055 16.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA HTH_40 PF14493.6 EDK38949.2 - 0.016 15.6 0.0 0.12 12.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain TED PF08341.11 EDK38949.2 - 0.12 12.7 0.1 1.6 9.2 0.0 2.3 2 0 0 2 2 2 0 Thioester domain AAA PF00004.29 EDK38950.2 - 1.4e-50 171.1 0.0 5.9e-43 146.4 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK38950.2 - 5.2e-08 32.6 0.0 1.4e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDK38950.2 - 5.5e-07 29.9 1.1 7.5e-06 26.2 0.0 3.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EDK38950.2 - 1.1e-05 25.9 0.2 0.00012 22.6 0.1 2.8 3 1 0 3 3 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EDK38950.2 - 3.9e-05 23.5 0.0 0.00011 22.0 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 EDK38950.2 - 0.00024 21.1 0.1 0.0012 18.8 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Bromodomain PF00439.25 EDK38950.2 - 0.00076 19.5 0.5 0.0036 17.3 0.1 2.4 2 0 0 2 2 2 1 Bromodomain AAA_14 PF13173.6 EDK38950.2 - 0.0019 18.2 0.0 0.02 14.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EDK38950.2 - 0.0044 17.0 2.8 0.073 13.1 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDK38950.2 - 0.0094 16.2 2.7 0.11 12.8 0.3 3.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK38950.2 - 0.01 16.2 0.0 0.069 13.5 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 EDK38950.2 - 0.011 15.8 0.4 0.065 13.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDK38950.2 - 0.016 14.9 0.1 0.12 12.1 0.0 2.3 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDK38950.2 - 0.024 14.0 0.2 0.071 12.5 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EDK38950.2 - 0.035 13.8 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EDK38950.2 - 0.037 14.2 0.0 0.77 9.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 EDK38950.2 - 0.043 13.7 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDK38950.2 - 0.054 13.7 0.0 0.23 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EDK38950.2 - 0.059 13.1 0.1 0.89 9.2 0.0 2.8 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_7 PF12775.7 EDK38950.2 - 0.087 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EDK38950.2 - 0.09 13.3 1.9 0.56 10.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EDK38950.2 - 0.12 12.0 0.0 0.33 10.5 0.0 1.7 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EDK38950.2 - 0.16 12.4 0.0 0.16 12.4 0.0 2.6 3 1 0 3 3 1 0 ABC transporter AAA_11 PF13086.6 EDK38950.2 - 0.44 10.3 0.0 0.44 10.3 0.0 3.9 3 2 0 3 3 1 0 AAA domain Spt4 PF06093.13 EDK38951.1 - 4.8e-31 106.7 0.0 5.7e-31 106.4 0.0 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger A2L_zn_ribbon PF08792.10 EDK38951.1 - 0.07 12.9 0.3 3.1 7.6 0.0 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-ACC PF17848.1 EDK38951.1 - 0.08 13.0 0.4 0.19 11.8 0.4 1.6 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain 60KD_IMP PF02096.20 EDK38952.2 - 1.7e-14 54.1 7.1 1.3e-12 47.9 2.4 2.1 2 0 0 2 2 2 2 60Kd inner membrane protein HHH PF00633.23 EDK38953.2 - 0.018 14.9 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Gemini_AL1_M PF08283.11 EDK38953.2 - 0.032 14.3 0.5 0.42 10.7 0.1 2.6 2 0 0 2 2 2 0 Geminivirus rep protein central domain Tfb2 PF03849.14 EDK38953.2 - 0.033 13.2 0.3 0.05 12.6 0.3 1.2 1 0 0 1 1 1 0 Transcription factor Tfb2 NPA PF16469.5 EDK38953.2 - 0.052 14.1 0.2 0.13 12.8 0.1 1.8 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 SPRY PF00622.28 EDK38954.2 - 0.0012 18.9 0.1 0.004 17.2 0.0 2.0 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.9 EDK38954.2 - 0.035 14.0 1.5 0.12 12.3 1.5 1.9 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Kdo PF06293.14 EDK38955.2 - 1.1e-08 34.7 0.0 1.8e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EDK38955.2 - 1e-06 28.3 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDK38955.2 - 2.8e-06 27.5 0.0 0.00064 19.7 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EDK38955.2 - 3.7e-06 26.7 0.0 1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EDK38955.2 - 0.00072 18.9 0.0 0.00081 18.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EDK38955.2 - 0.0044 16.6 0.1 0.0086 15.7 0.1 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EDK38955.2 - 0.012 14.9 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase MARVEL PF01284.23 EDK38957.1 - 1.3e-21 77.1 20.4 1.8e-21 76.7 20.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF5504 PF17608.2 EDK38957.1 - 0.00088 19.4 3.2 0.00088 19.4 3.2 1.8 1 1 1 2 2 2 1 Family of unknown function (DUF5504) GP3 PF03076.14 EDK38957.1 - 0.034 14.2 3.3 0.049 13.7 3.3 1.2 1 0 0 1 1 1 0 Equine arteritis virus GP3 DUF2070 PF09843.9 EDK38957.1 - 0.75 8.0 13.5 0.97 7.6 13.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ribonuclease_T2 PF00445.18 EDK38958.2 - 4.2e-42 144.4 3.5 9.1e-42 143.3 3.5 1.5 1 0 0 1 1 1 1 Ribonuclease T2 family Ricin_B_lectin PF00652.22 EDK38958.2 - 0.051 13.8 7.7 0.13 12.5 0.6 3.3 3 0 0 3 3 3 0 Ricin-type beta-trefoil lectin domain AdoHcyase PF05221.17 EDK38959.1 - 9.2e-128 425.6 0.0 2.4e-73 246.9 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EDK38959.1 - 1.7e-82 275.3 2.7 2.6e-82 274.7 2.7 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDK38959.1 - 8.1e-07 28.6 0.1 2.3e-06 27.1 0.1 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDK38959.1 - 0.015 14.9 0.1 0.026 14.1 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EDK38959.1 - 0.09 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain GATA PF00320.27 EDK38960.2 - 3.8e-16 58.4 4.1 7.5e-16 57.5 4.1 1.5 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDK38960.2 - 0.11 12.0 0.9 0.22 11.1 0.9 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding IF4E PF01652.18 EDK38961.2 - 3.6e-28 98.4 0.1 6.1e-28 97.6 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RibD_C PF01872.17 EDK38961.2 - 0.059 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 RibD C-terminal domain Peptidase_M20 PF01546.28 EDK38962.1 - 5.1e-32 111.3 0.0 6.7e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK38962.1 - 9.6e-12 44.8 0.0 1.9e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDK38962.1 - 0.021 14.5 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 PgdA_N PF18627.1 EDK38962.1 - 0.15 11.7 0.2 0.48 10.0 0.1 1.7 2 0 0 2 2 2 0 Peptidoglycan GlcNAc deacetylase N-terminal domain FSH1 PF03959.13 EDK38964.1 - 3.2e-67 226.3 0.0 3.8e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EDK38964.1 - 0.00071 19.4 0.5 0.019 14.8 0.1 2.9 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EDK38964.1 - 0.21 10.8 0.0 3 7.0 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Thioredoxin PF00085.20 EDK38965.2 - 5.7e-23 80.9 0.6 2.5e-22 78.8 0.2 2.2 2 1 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 EDK38965.2 - 1.2e-08 34.7 0.6 2.2e-08 33.8 0.4 1.4 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDK38965.2 - 4.9e-06 26.8 2.6 7e-05 23.1 0.1 3.2 2 2 1 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EDK38965.2 - 9.4e-06 26.0 0.9 4.1e-05 24.0 0.5 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.6 EDK38965.2 - 0.00059 19.7 0.0 0.00059 19.7 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EDK38965.2 - 0.00065 19.6 0.2 0.0021 18.0 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDK38965.2 - 0.0079 15.9 0.2 0.015 15.0 0.2 1.4 1 0 0 1 1 1 1 Redoxin Glutaredoxin PF00462.24 EDK38965.2 - 0.14 12.4 0.4 4.9 7.4 0.2 2.5 2 0 0 2 2 2 0 Glutaredoxin Peptidase_C12 PF01088.21 EDK38966.2 - 5.7e-62 209.2 0.0 7.4e-62 208.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EDK38966.2 - 9.6e-09 35.0 0.0 2.1e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Scramblase PF03803.15 EDK38967.2 - 3.6e-62 209.5 0.0 4.9e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 Scramblase Mito_carr PF00153.27 EDK38968.1 - 1.2e-67 223.9 0.7 1.1e-22 79.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EDK38969.2 - 3.1e-06 26.9 0.0 8e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arginase PF00491.21 EDK38970.1 - 4.5e-64 216.7 0.0 5.3e-64 216.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.17 EDK38971.2 - 2.4e-75 253.6 0.4 2e-74 250.6 0.0 2.5 2 1 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EDK38971.2 - 3.8e-26 91.5 0.1 1.1e-13 51.6 0.0 4.6 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK38971.2 - 1.1e-16 61.0 0.9 0.00011 22.7 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK38971.2 - 3e-15 56.1 0.1 0.0001 22.5 0.1 4.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) SPX PF03105.19 EDK38971.2 - 1.4e-14 54.9 25.0 6.1e-11 42.9 0.2 4.6 5 0 0 5 5 5 3 SPX domain Ank_3 PF13606.6 EDK38971.2 - 4.3e-14 51.3 5.1 0.22 12.2 0.0 7.6 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 EDK38971.2 - 4e-13 49.2 2.4 0.2 12.2 0.0 6.1 5 1 0 5 5 5 4 Ankyrin repeat TIP41 PF04176.13 EDK38972.2 - 4.3e-67 224.9 0.0 5.7e-67 224.5 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family Sod_Fe_C PF02777.18 EDK38973.2 - 1.6e-18 66.8 0.1 1.6e-16 60.4 0.1 2.6 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Miga PF10265.9 EDK38974.2 - 0.14 11.1 3.3 0.055 12.5 0.5 1.6 2 0 0 2 2 2 0 Mitoguardin TPR_1 PF00515.28 EDK38975.2 - 0.00063 19.5 0.2 0.00063 19.5 0.2 2.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK38975.2 - 0.00067 19.6 8.9 0.00071 19.5 0.3 4.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDK38975.2 - 0.39 10.4 2.4 1.2 8.9 2.4 1.9 1 1 0 1 1 1 0 TPR repeat CTP_synth_N PF06418.14 EDK38976.1 - 7.4e-123 409.0 0.3 1.1e-122 408.4 0.3 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EDK38976.1 - 1.6e-55 187.8 0.0 2.4e-55 187.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDK38976.1 - 1.7e-05 24.7 0.1 6.9e-05 22.7 0.1 2.1 1 1 0 1 1 1 1 Peptidase C26 Linocin_M18 PF04454.12 EDK38976.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Encapsulating protein for peroxidase ESCRT-II PF05871.12 EDK38978.2 - 1.2e-38 132.5 0.1 2e-38 131.8 0.0 1.4 2 0 0 2 2 2 1 ESCRT-II complex subunit SCA7 PF08313.12 EDK38979.2 - 0.00091 19.1 1.7 0.0023 17.8 1.7 1.6 1 0 0 1 1 1 1 SCA7, zinc-binding domain LRR_4 PF12799.7 EDK38980.2 - 3.3e-14 52.8 13.1 0.094 13.2 0.4 8.0 5 2 2 7 7 7 5 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EDK38980.2 - 3.8e-11 42.7 0.6 1.1e-10 41.2 0.6 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK38980.2 - 1.8e-06 27.7 0.9 7.7e-06 25.6 0.9 2.2 1 0 0 1 1 1 1 F-box domain DUF1699 PF08004.11 EDK38980.2 - 0.00012 21.7 0.3 13 5.5 0.0 4.8 4 1 0 4 4 4 2 Protein of unknown function (DUF1699) LRR_8 PF13855.6 EDK38980.2 - 0.0012 18.6 3.8 3.7 7.4 0.0 5.1 6 1 0 6 6 6 2 Leucine rich repeat F-box_4 PF15966.5 EDK38980.2 - 0.0013 18.6 0.0 0.0053 16.6 0.0 2.1 1 0 0 1 1 1 1 F-box LRR_5 PF13306.6 EDK38980.2 - 0.0032 17.4 1.0 1.5 8.8 0.4 3.0 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) PRANC PF09372.10 EDK38980.2 - 0.03 14.7 0.1 0.12 12.7 0.1 2.1 1 0 0 1 1 1 0 PRANC domain DMA PF03474.14 EDK38980.2 - 0.069 12.8 0.2 0.19 11.3 0.2 1.8 1 0 0 1 1 1 0 DMRTA motif RNA_pol_Rpb5_N PF03871.14 EDK38980.2 - 0.15 12.6 0.0 0.36 11.4 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain LRR_6 PF13516.6 EDK38980.2 - 0.33 11.1 19.7 23 5.4 0.0 8.9 11 0 0 11 11 11 0 Leucine Rich repeat PUF PF00806.19 EDK38981.2 - 2.5e-25 86.7 0.4 5.2e-05 22.7 0.0 5.9 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat PCI PF01399.27 EDK38983.2 - 9.9e-16 58.2 0.5 3.9e-14 53.0 0.1 2.9 2 1 0 2 2 2 1 PCI domain eIF-5_eIF-2B PF01873.17 EDK38984.1 - 6.3e-39 132.5 0.1 2e-38 130.9 0.1 1.8 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 EDK38984.1 - 7.3e-25 86.9 2.0 1.2e-23 83.0 0.0 2.7 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Nudix_N_2 PF14803.6 EDK38984.1 - 0.0019 18.1 1.4 0.0044 16.9 1.4 1.5 1 0 0 1 1 1 1 Nudix N-terminal Zn-ribbon_8 PF09723.10 EDK38984.1 - 0.18 11.9 1.0 0.41 10.8 1.0 1.6 1 0 0 1 1 1 0 Zinc ribbon domain NopRA1 PF16201.5 EDK38985.2 - 8.3e-36 123.5 0.0 1e-34 119.9 0.0 2.8 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Npa1 PF11707.8 EDK38986.2 - 3.2e-56 191.1 9.0 4.1e-56 190.8 9.0 1.0 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Phage_HK97_TLTM PF06120.11 EDK38986.2 - 0.066 12.4 0.2 0.094 11.9 0.2 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Bul1_N PF04425.12 EDK38987.2 - 3.7e-50 171.0 11.1 1.6e-40 139.3 0.2 3.1 1 1 2 3 3 3 3 Bul1 N terminus Bul1_C PF04426.12 EDK38987.2 - 1.2e-05 24.9 5.7 0.011 15.2 1.1 2.8 1 1 1 2 2 2 2 Bul1 C terminus GAS PF13851.6 EDK38987.2 - 0.028 13.8 0.2 0.028 13.8 0.2 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Pkinase PF00069.25 EDK38988.2 - 6.2e-62 209.3 0.4 1.4e-61 208.2 0.4 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK38988.2 - 1e-24 87.2 0.0 2.4e-24 86.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK38988.2 - 0.00021 20.7 0.0 0.37 10.0 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EDK38988.2 - 0.00034 19.5 0.0 0.00064 18.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PI3K_1B_p101 PF10486.9 EDK38988.2 - 0.6 7.8 7.2 0.95 7.2 7.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ABC_tran PF00005.27 EDK38990.2 - 1.1e-38 132.8 0.2 5.3e-22 78.8 0.1 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EDK38990.2 - 1.5e-21 76.8 16.0 2.3e-21 76.2 16.0 1.3 1 0 0 1 1 1 1 ABC-2 type transporter RsgA_GTPase PF03193.16 EDK38990.2 - 6e-09 36.0 1.4 0.00073 19.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK38990.2 - 7.5e-09 36.2 0.0 0.00044 20.7 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDK38990.2 - 3e-08 34.0 0.5 0.0073 16.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EDK38990.2 - 1.6e-07 31.7 0.8 0.022 15.0 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDK38990.2 - 4.2e-07 29.6 1.3 0.017 14.9 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EDK38990.2 - 4.7e-07 29.5 1.9 0.00078 18.9 0.3 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EDK38990.2 - 5.2e-07 30.3 0.1 0.025 15.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EDK38990.2 - 6.6e-07 28.7 1.8 0.0064 15.6 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_30 PF13604.6 EDK38990.2 - 1e-06 28.6 0.0 0.033 13.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDK38990.2 - 1.2e-06 28.5 0.1 0.061 13.2 0.2 2.5 2 0 0 2 2 2 2 NACHT domain ATP_bind_1 PF03029.17 EDK38990.2 - 2.9e-06 27.3 0.1 0.044 13.6 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EDK38990.2 - 4.1e-06 26.8 4.6 0.022 14.8 0.3 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase ATPase_2 PF01637.18 EDK38990.2 - 5.9e-06 26.4 1.1 0.02 14.8 0.0 3.2 3 0 0 3 3 3 2 ATPase domain predominantly from Archaea cobW PF02492.19 EDK38990.2 - 6.7e-06 25.8 1.3 0.029 13.9 0.1 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EDK38990.2 - 1e-05 25.5 0.1 0.049 13.5 0.0 2.4 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 EDK38990.2 - 1.5e-05 25.3 0.1 0.25 11.7 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_21 PF13304.6 EDK38990.2 - 2.4e-05 24.3 15.8 0.0022 17.8 0.4 3.9 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EDK38990.2 - 4.1e-05 23.8 0.4 0.13 12.4 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EDK38990.2 - 4.3e-05 23.3 0.3 0.16 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EDK38990.2 - 4.7e-05 23.4 0.1 0.08 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EDK38990.2 - 8.8e-05 22.9 0.3 0.29 11.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain PRK PF00485.18 EDK38990.2 - 8.9e-05 22.3 0.0 0.14 11.9 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 EDK38990.2 - 0.0002 21.3 0.3 0.28 11.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain SRP54 PF00448.22 EDK38990.2 - 0.00021 21.0 0.7 0.43 10.2 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 EDK38990.2 - 0.00026 20.9 0.1 0.77 9.7 0.0 2.4 2 0 0 2 2 2 2 NTPase Pox_A32 PF04665.12 EDK38990.2 - 0.0003 20.3 0.4 0.19 11.2 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_14 PF13173.6 EDK38990.2 - 0.00048 20.2 0.0 0.97 9.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain PduV-EutP PF10662.9 EDK38990.2 - 0.00057 19.6 0.1 1 9.1 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation KAP_NTPase PF07693.14 EDK38990.2 - 0.00093 18.5 0.7 1.6 7.9 0.0 3.3 2 1 1 3 3 3 1 KAP family P-loop domain dNK PF01712.19 EDK38990.2 - 0.001 19.0 0.1 2 8.2 0.0 2.4 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_17 PF13207.6 EDK38990.2 - 0.0013 19.2 0.9 1 9.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 EDK38990.2 - 0.0015 17.8 0.3 1.7 7.9 0.1 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 EDK38990.2 - 0.0016 18.0 0.5 0.67 9.4 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EDK38990.2 - 0.0023 18.3 2.9 2 8.8 0.0 3.5 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EDK38990.2 - 0.0024 17.6 0.0 1.3 8.7 0.0 2.6 3 0 0 3 3 2 1 Cytidylate kinase AAA_23 PF13476.6 EDK38990.2 - 0.0026 18.3 1.8 0.02 15.4 0.7 4.0 3 1 1 4 4 3 2 AAA domain Thymidylate_kin PF02223.17 EDK38990.2 - 0.003 17.3 0.0 1.2 8.8 0.1 2.5 2 0 0 2 2 2 1 Thymidylate kinase Septin PF00735.18 EDK38990.2 - 0.003 16.9 0.2 0.71 9.1 0.0 2.4 2 0 0 2 2 2 1 Septin TsaE PF02367.17 EDK38990.2 - 0.0036 17.3 0.5 1 9.4 0.1 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EDK38990.2 - 0.0037 16.5 0.0 2 7.5 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain DUF2075 PF09848.9 EDK38990.2 - 0.0046 16.3 1.0 1.8 7.8 0.0 2.5 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EDK38990.2 - 0.0057 16.3 0.4 0.23 11.0 0.2 2.4 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 EDK38990.2 - 0.0071 16.0 0.0 2.4 7.7 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Roc PF08477.13 EDK38990.2 - 0.0075 16.5 0.1 8 6.7 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDK38990.2 - 0.0092 15.4 2.7 1.4 8.4 0.0 2.7 3 0 0 3 3 2 1 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.21 EDK38990.2 - 0.01 15.2 0.4 1.1 8.6 0.0 3.1 4 0 0 4 4 3 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 EDK38990.2 - 0.016 15.1 0.5 4.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase CbiA PF01656.23 EDK38990.2 - 0.016 15.2 0.4 1.9 8.5 0.1 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain FtsK_SpoIIIE PF01580.18 EDK38990.2 - 0.017 14.5 2.0 0.58 9.5 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family FeoB_N PF02421.18 EDK38990.2 - 0.021 14.4 1.5 0.99 8.9 0.2 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B SbcCD_C PF13558.6 EDK38990.2 - 0.031 14.5 0.3 0.24 11.7 0.0 2.5 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit PIF1 PF05970.14 EDK38990.2 - 0.033 13.4 0.3 6.2 5.9 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase GTP_EFTU PF00009.27 EDK38990.2 - 0.041 13.4 0.0 7.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TrwB_AAD_bind PF10412.9 EDK38990.2 - 0.081 11.8 1.0 1.1 8.1 0.2 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MeaB PF03308.16 EDK38990.2 - 0.082 11.9 0.2 5.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 EDK38990.2 - 0.13 12.3 8.2 0.82 9.7 0.1 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain CLP1_P PF16575.5 EDK38990.2 - 0.8 9.5 3.6 8.2 6.2 0.1 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Dynamin_N PF00350.23 EDK38990.2 - 4.8 7.2 10.1 9.9 6.2 0.1 3.7 3 1 0 3 3 3 0 Dynamin family AAA_11 PF13086.6 EDK38990.2 - 7.4 6.3 7.7 9.7 5.9 0.1 3.3 4 0 0 4 4 3 0 AAA domain ABC_tran PF00005.27 EDK38991.2 - 5.2e-51 172.8 3.2 1.1e-24 87.4 0.1 3.0 3 0 0 3 3 3 2 ABC transporter ABC2_membrane PF01061.24 EDK38991.2 - 6e-40 136.9 36.4 4.2e-23 81.9 11.4 2.5 2 0 0 2 2 2 2 ABC-2 type transporter SMC_N PF02463.19 EDK38991.2 - 1.1e-13 51.2 0.1 1.5e-05 24.5 0.0 3.0 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK38991.2 - 1.9e-13 50.9 15.7 0.00052 19.9 0.1 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDK38991.2 - 7.3e-11 42.2 0.9 0.00038 20.4 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK38991.2 - 5.1e-10 40.0 0.3 0.0012 19.3 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDK38991.2 - 8.4e-09 35.8 0.8 0.002 18.4 0.1 3.3 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDK38991.2 - 3.3e-08 33.1 0.3 0.008 15.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EDK38991.2 - 1.3e-07 32.4 3.2 0.0022 18.5 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EDK38991.2 - 2.8e-06 27.9 1.0 0.072 13.6 0.0 3.6 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.23 EDK38991.2 - 4.5e-06 26.7 1.8 0.02 15.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RNA_helicase PF00910.22 EDK38991.2 - 1.1e-05 25.8 0.4 0.11 12.9 0.1 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 EDK38991.2 - 1.7e-05 24.8 0.2 0.25 11.2 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 EDK38991.2 - 2.2e-05 24.9 0.4 1.5 9.3 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDK38991.2 - 2.5e-05 24.6 0.3 0.22 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EDK38991.2 - 7.1e-05 22.8 0.1 0.35 10.9 0.0 3.1 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK38991.2 - 0.0001 22.5 0.1 0.57 10.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EDK38991.2 - 0.00011 22.2 1.4 0.04 13.8 0.0 2.8 3 0 0 3 3 2 1 Rad17 P-loop domain FtsK_SpoIIIE PF01580.18 EDK38991.2 - 0.00018 20.9 0.2 0.027 13.8 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_30 PF13604.6 EDK38991.2 - 0.00019 21.2 0.1 0.42 10.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EDK38991.2 - 0.0003 19.9 0.0 0.5 9.4 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein PRK PF00485.18 EDK38991.2 - 0.00031 20.6 0.7 0.15 11.8 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_15 PF13175.6 EDK38991.2 - 0.0006 19.6 0.1 0.61 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 EDK38991.2 - 0.00076 19.7 2.2 1.6 9.0 0.0 4.1 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EDK38991.2 - 0.00092 19.4 0.2 2.4 8.4 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EDK38991.2 - 0.001 19.1 0.0 0.75 9.7 0.0 2.7 2 1 1 3 3 2 1 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 EDK38991.2 - 0.0017 18.1 2.3 1.2 8.9 0.2 2.5 2 0 0 2 2 2 2 Cytidylate kinase AAA_24 PF13479.6 EDK38991.2 - 0.0026 17.5 0.0 2.3 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 EDK38991.2 - 0.0026 17.6 0.4 2.3 8.0 0.1 2.4 2 0 0 2 2 2 1 Deoxynucleoside kinase IstB_IS21 PF01695.17 EDK38991.2 - 0.0047 16.7 0.0 24 4.6 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein KAP_NTPase PF07693.14 EDK38991.2 - 0.0068 15.7 0.0 2.5 7.2 0.0 2.4 2 0 0 2 2 2 1 KAP family P-loop domain Septin PF00735.18 EDK38991.2 - 0.0069 15.7 0.2 0.84 8.9 0.0 2.3 2 0 0 2 2 2 1 Septin AAA_17 PF13207.6 EDK38991.2 - 0.0072 16.8 0.3 2.9 8.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 EDK38991.2 - 0.0078 15.8 0.8 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 EDK38991.2 - 0.0086 16.1 0.0 6.9 6.7 0.0 3.2 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 EDK38991.2 - 0.011 14.9 0.5 2.8 7.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 EDK38991.2 - 0.013 15.3 0.2 4.5 7.0 0.1 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ploopntkinase3 PF18751.1 EDK38991.2 - 0.016 15.2 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 EDK38991.2 - 0.019 14.5 0.2 6.7 6.2 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 EDK38991.2 - 0.023 14.8 8.7 0.91 9.6 0.1 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain SRPRB PF09439.10 EDK38991.2 - 0.04 13.4 0.9 5.7 6.3 0.0 2.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit CLP1_P PF16575.5 EDK38991.2 - 0.043 13.6 1.1 0.42 10.4 0.1 2.3 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP-synt_ab PF00006.25 EDK38991.2 - 0.055 13.1 0.0 0.74 9.4 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 EDK38991.2 - 0.06 12.5 0.0 9.3 5.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Pox_A32 PF04665.12 EDK38991.2 - 0.065 12.7 0.4 4.5 6.6 0.1 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein Dynamin_N PF00350.23 EDK38991.2 - 0.066 13.3 3.4 0.16 12.1 0.1 2.5 2 0 0 2 2 2 0 Dynamin family Viral_helicase1 PF01443.18 EDK38991.2 - 0.081 12.7 0.2 15 5.2 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EDK38991.2 - 0.093 12.0 0.1 2.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin G-alpha PF00503.20 EDK38991.2 - 0.11 11.6 0.1 9.5 5.3 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Guanylate_kin PF00625.21 EDK38991.2 - 0.11 12.1 0.3 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Guanylate kinase AAA_13 PF13166.6 EDK38991.2 - 0.14 10.8 0.3 0.7 8.5 0.0 2.1 3 0 0 3 3 2 0 AAA domain MeaB PF03308.16 EDK38991.2 - 0.15 11.0 0.1 9.2 5.1 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EDK38991.2 - 0.15 12.0 0.7 3.7 7.4 0.1 2.9 3 0 0 3 3 3 0 NTPase SRP54 PF00448.22 EDK38991.2 - 0.19 11.3 0.5 10 5.7 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EDK38991.2 - 0.23 11.0 0.2 25 4.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EDK38991.2 - 0.23 11.4 0.5 5.7 6.8 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PDR_CDR PF06422.12 EDK38991.2 - 0.32 10.9 4.1 0.13 12.2 0.2 2.4 2 0 0 2 2 1 0 CDR ABC transporter SurE PF01975.17 EDK38992.2 - 1e-42 146.1 0.0 1.3e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE PAP2_3 PF14378.6 EDK38993.2 - 8.7e-15 54.9 14.1 2.2e-14 53.6 14.1 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.21 EDK38993.2 - 1.2e-12 47.7 5.7 1.2e-12 47.7 5.7 2.6 3 0 0 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 EDK38993.2 - 0.00018 22.0 6.6 0.00018 22.0 6.6 4.1 5 1 0 5 5 5 1 PAP2 superfamily C-terminal Mt_ATP-synt_D PF05873.12 EDK38994.2 - 8.4e-19 67.9 5.7 1e-18 67.7 5.7 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Vps51 PF08700.11 EDK38994.2 - 0.013 15.6 6.4 0.069 13.2 0.4 2.2 1 1 1 2 2 2 0 Vps51/Vps67 RNR_N PF08343.10 EDK38994.2 - 0.037 14.1 0.7 0.12 12.4 0.1 2.1 1 1 2 3 3 3 0 Ribonucleotide reductase N-terminal Dor1 PF04124.12 EDK38994.2 - 0.048 12.4 2.5 0.055 12.2 2.5 1.1 1 0 0 1 1 1 0 Dor1-like family TMPIT PF07851.13 EDK38994.2 - 0.58 9.4 4.0 0.75 9.0 4.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein XhlA PF10779.9 EDK38994.2 - 1.9 8.7 6.7 0.86 9.9 3.2 2.2 2 1 1 3 3 3 0 Haemolysin XhlA Adaptin_N PF01602.20 EDK38995.2 - 5.1e-82 276.1 7.5 6.6e-66 223.0 2.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 EDK38995.2 - 0.00039 20.5 0.9 0.0077 16.3 0.0 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Alpha_adaptin_C PF02296.16 EDK38995.2 - 0.003 17.7 0.0 0.0089 16.2 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain PUL PF08324.11 EDK38995.2 - 0.01 15.1 0.1 5.8 6.1 0.0 2.7 2 0 0 2 2 2 0 PUL domain Arm PF00514.23 EDK38995.2 - 0.13 12.4 0.2 2.6 8.2 0.0 3.0 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat CAP PF00188.26 EDK38996.2 - 7.9e-18 65.5 5.0 7.9e-18 65.5 5.0 2.2 2 2 0 2 2 2 1 Cysteine-rich secretory protein family PseudoU_synth_2 PF00849.22 EDK38997.2 - 6.4e-28 97.8 0.0 1.1e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF4558 PF15104.6 EDK38997.2 - 0.16 12.0 0.8 0.23 11.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) rRNA_methylase PF06962.12 EDK38998.2 - 0.09 12.8 0.1 8.7 6.3 0.0 2.3 2 0 0 2 2 2 0 Putative rRNA methylase WD40 PF00400.32 EDK38999.2 - 1.1e-16 60.9 2.3 4.1e-05 24.2 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK38999.2 - 8.1e-09 35.7 0.0 0.00047 20.4 0.0 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDK38999.2 - 0.013 14.0 0.0 0.068 11.7 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain SH3_1 PF00018.28 EDK39000.2 - 4.2e-11 42.3 0.1 4.2e-11 42.3 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EDK39000.2 - 1.7e-09 37.2 0.0 3.3e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EDK39000.2 - 1.7e-09 37.4 0.1 3.5e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Anoctamin PF04547.12 EDK39001.2 - 2.9e-68 230.8 15.7 3.8e-68 230.4 15.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Ala_racemase_N PF01168.20 EDK39002.2 - 6.8e-27 94.5 0.0 8.5e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHQS PF01959.16 EDK39002.2 - 0.052 12.5 0.0 0.1 11.5 0.0 1.5 1 0 0 1 1 1 0 3-dehydroquinate synthase II SMAP PF15477.6 EDK39002.2 - 0.14 13.1 0.1 0.37 11.8 0.1 1.6 1 0 0 1 1 1 0 Small acidic protein family La PF05383.17 EDK39003.1 - 1.7e-21 76.0 0.1 3.2e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EDK39003.1 - 7e-06 25.8 0.1 0.00017 21.3 0.1 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nre_N PF04894.12 EDK39003.1 - 0.026 14.4 0.3 0.055 13.3 0.0 1.6 2 0 0 2 2 2 0 Archaeal Nre, N-terminal Pol_alpha_B_N PF08418.10 EDK39004.2 - 1.4e-25 90.7 6.1 1.7e-25 90.4 6.1 1.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EDK39005.2 - 3.8e-10 39.5 0.1 5.1e-10 39.1 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_E_B PF04042.16 EDK39006.2 - 4.2e-06 26.3 0.0 6.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B EII-Sor PF03609.14 EDK39006.2 - 0.15 11.4 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 PTS system sorbose-specific iic component ResIII PF04851.15 EDK39007.2 - 8.2e-25 87.8 0.3 5.1e-24 85.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDK39007.2 - 2.4e-15 56.9 2.0 8.8e-15 55.0 0.1 2.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDK39007.2 - 6.6e-11 42.3 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EDK39007.2 - 4.7e-07 29.7 0.1 1.2e-06 28.4 0.0 1.7 2 0 0 2 2 2 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EDK39007.2 - 0.0011 18.2 0.0 0.0025 17.1 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EDK39007.2 - 0.026 14.6 0.0 0.083 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4869 PF16163.5 EDK39007.2 - 0.031 14.0 0.4 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4869) Peptidase_C13 PF01650.18 EDK39008.2 - 3.6e-47 161.0 0.5 5.4e-47 160.5 0.5 1.3 1 0 0 1 1 1 1 Peptidase C13 family CLASP_N PF12348.8 EDK39009.2 - 3.9e-89 298.1 14.7 6.1e-79 264.8 4.5 3.1 3 0 0 3 3 3 2 CLASP N terminal MNE1 PF13762.6 EDK39009.2 - 0.011 15.7 1.3 0.25 11.3 0.2 3.2 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component HEAT PF02985.22 EDK39009.2 - 0.019 15.2 0.0 10 6.7 0.0 3.3 2 0 0 2 2 2 0 HEAT repeat BK_channel_a PF03493.18 EDK39009.2 - 0.21 11.8 1.4 0.7 10.1 0.1 2.5 3 0 0 3 3 3 0 Calcium-activated BK potassium channel alpha subunit HEAT_EZ PF13513.6 EDK39009.2 - 0.21 12.1 0.2 97 3.6 0.0 3.9 4 0 0 4 4 4 0 HEAT-like repeat Cnd1 PF12717.7 EDK39009.2 - 8.1 6.5 8.2 19 5.3 0.0 4.3 4 1 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 STE PF02200.16 EDK39010.2 - 5.3e-57 191.0 1.6 8.8e-57 190.3 1.6 1.4 1 0 0 1 1 1 1 STE like transcription factor DUF3591 PF12157.8 EDK39012.2 - 7.6e-184 611.5 6.1 1.4e-183 610.6 6.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 EDK39012.2 - 9.4e-07 28.6 1.0 3.1e-06 26.9 0.8 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EDK39012.2 - 0.85 9.8 3.6 0.22 11.6 0.6 1.6 2 0 0 2 2 2 0 Zinc knuckle Pkinase PF00069.25 EDK39013.2 - 7.2e-48 163.2 0.0 4.7e-46 157.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39013.2 - 2.7e-26 92.4 0.0 1.7e-25 89.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK39013.2 - 0.00069 18.7 0.0 0.0014 17.7 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Thioredoxin_7 PF13899.6 EDK39014.2 - 1e-20 73.7 0.0 2.2e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 EDK39014.2 - 7.6e-11 42.1 0.0 2.1e-10 40.6 0.0 1.8 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EDK39014.2 - 1.1e-10 41.2 0.1 3.8e-10 39.4 0.0 2.0 2 0 0 2 2 2 1 UBA-like domain UIM PF02809.20 EDK39014.2 - 0.029 14.3 1.7 0.029 14.3 1.7 2.4 2 0 0 2 2 2 0 Ubiquitin interaction motif Thioredoxin_2 PF13098.6 EDK39014.2 - 0.042 14.3 0.2 0.17 12.4 0.2 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredox_DsbH PF03190.15 EDK39014.2 - 0.052 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 SGTA_dimer PF16546.5 EDK39014.2 - 0.18 11.6 1.9 0.37 10.6 0.4 2.3 2 0 0 2 2 2 0 Homodimerisation domain of SGTA Tub_N PF16322.5 EDK39014.2 - 1.2 9.5 8.3 0.37 11.2 1.3 2.3 2 0 0 2 2 2 0 Tubby N-terminal PRESAN PF09687.10 EDK39015.2 - 0.22 12.0 5.9 0.21 12.1 2.9 2.4 2 1 0 2 2 2 0 Plasmodium RESA N-terminal ADIP PF11559.8 EDK39015.2 - 0.23 11.5 8.1 3 7.9 1.5 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sds3 PF08598.11 EDK39015.2 - 0.35 10.8 11.0 0.68 9.9 11.0 1.7 1 1 0 1 1 1 0 Sds3-like Skp1 PF01466.19 EDK39016.2 - 4.7e-25 87.4 1.1 7.3e-25 86.8 0.4 1.7 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EDK39016.2 - 1.8e-19 69.7 0.1 4.1e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain TBK1_CCD1 PF18394.1 EDK39016.2 - 0.023 14.2 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 Peroxin-3 PF04882.12 EDK39017.2 - 7.8e-107 358.2 18.3 5.9e-104 348.7 18.3 2.7 1 1 0 1 1 1 1 Peroxin-3 XPC-binding PF09280.11 EDK39017.2 - 0.11 12.3 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 XPC-binding domain VASt PF16016.5 EDK39018.2 - 2.4e-39 135.2 0.1 6.1e-39 133.9 0.1 1.8 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDK39018.2 - 2.3e-28 98.3 0.1 5.1e-28 97.2 0.1 1.6 1 0 0 1 1 1 1 GRAM domain MAT1 PF06391.13 EDK39018.2 - 4.6 7.0 10.6 0.078 12.8 1.5 2.7 3 0 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 Ribonuc_2-5A PF06479.12 EDK39019.2 - 4.4e-45 153.0 3.5 4.6e-44 149.6 2.4 2.6 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 EDK39019.2 - 1.2e-37 129.7 0.0 7e-37 127.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39019.2 - 1.2e-22 80.4 0.0 9.4e-22 77.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EDK39019.2 - 2e-05 24.3 0.0 0.021 14.7 0.0 3.5 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_2 PF13360.6 EDK39019.2 - 0.0045 16.6 0.0 0.066 12.8 0.0 2.4 2 0 0 2 2 2 1 PQQ-like domain Pkinase_fungal PF17667.1 EDK39019.2 - 0.0047 15.8 2.8 0.016 14.0 0.0 2.6 2 1 0 3 3 3 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EDK39019.2 - 0.014 14.4 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EDK39019.2 - 0.041 13.2 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sas10_Utp3 PF04000.15 EDK39020.2 - 6e-12 46.0 0.1 6e-12 46.0 0.1 2.3 2 1 1 3 3 3 1 Sas10/Utp3/C1D family NPV_P10 PF05531.12 EDK39020.2 - 0.0018 18.7 0.5 1.4 9.4 0.1 2.3 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein DRIM PF07539.12 EDK39020.2 - 0.0091 14.4 0.1 0.011 14.1 0.1 1.1 1 0 0 1 1 1 1 Down-regulated in metastasis FlaC_arch PF05377.11 EDK39020.2 - 0.019 15.4 3.8 3.8 8.0 0.1 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) NOG1_N PF17835.1 EDK39020.2 - 0.029 14.3 0.4 0.082 12.9 0.3 1.7 2 0 0 2 2 2 0 NOG1 N-terminal helical domain EF-hand_14 PF17959.1 EDK39020.2 - 0.038 14.3 0.1 0.079 13.3 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain SlyX PF04102.12 EDK39020.2 - 0.25 12.0 1.2 9.7 6.9 0.0 2.3 2 0 0 2 2 2 0 SlyX Nop25 PF09805.9 EDK39021.2 - 4.4e-40 137.3 21.7 4.4e-40 137.3 21.7 2.2 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) Cytomega_UL84 PF06284.11 EDK39021.2 - 2.1 6.7 4.4 3 6.2 4.4 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein EXS PF03124.14 EDK39022.2 - 4.9e-70 236.5 13.7 5.7e-70 236.3 13.7 1.0 1 0 0 1 1 1 1 EXS family Ribonuclease_3 PF00636.26 EDK39024.2 - 1.2e-07 32.3 0.0 3.8e-07 30.7 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDK39024.2 - 9.5e-06 25.8 0.0 0.064 13.4 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EDK39024.2 - 0.0023 18.6 0.0 0.0064 17.2 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif VacA2 PF03077.14 EDK39024.2 - 0.087 12.7 0.3 0.16 11.8 0.3 1.4 1 0 0 1 1 1 0 Putative vacuolating cytotoxin GARS_A PF01071.19 EDK39025.2 - 1.8e-80 269.3 0.0 4e-80 268.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EDK39025.2 - 7.5e-34 116.4 1.4 4.8e-33 113.8 0.0 2.9 3 1 0 3 3 3 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EDK39025.2 - 2.4e-33 115.5 0.0 4.7e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EDK39025.2 - 1.6e-25 89.2 1.4 4e-25 87.9 1.4 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EDK39025.2 - 1.9e-15 57.3 2.2 1.4e-14 54.5 2.0 2.4 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 EDK39025.2 - 1.9e-05 24.3 0.0 4.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EDK39025.2 - 2.8e-05 24.2 0.0 0.00012 22.2 0.0 2.0 2 1 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 EDK39025.2 - 0.0026 17.4 3.7 0.0047 16.5 0.0 3.2 5 0 0 5 5 5 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.17 EDK39025.2 - 0.018 14.6 0.1 0.038 13.5 0.1 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain GCS PF03074.16 EDK39026.2 - 2.4e-145 484.5 0.0 3.3e-145 484.1 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 EDK39026.2 - 0.071 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) adh_short PF00106.25 EDK39027.2 - 6.4e-46 156.3 0.0 8.5e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39027.2 - 2.2e-32 112.5 0.0 2.9e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK39027.2 - 7.6e-08 32.5 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK39027.2 - 7.4e-06 25.6 0.0 4.4e-05 23.1 0.0 2.2 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EDK39027.2 - 0.0098 15.3 0.0 0.16 11.3 0.0 2.4 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EDK39027.2 - 0.054 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Eno-Rase_NADH_b PF12242.8 EDK39027.2 - 0.14 11.9 0.3 0.29 10.9 0.3 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Sugar_tr PF00083.24 EDK39028.2 - 1.7e-63 215.1 21.5 2e-63 214.8 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39028.2 - 1.1e-24 87.0 24.3 1.1e-24 87.0 24.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily SMI1_KNR4 PF09346.10 EDK39029.2 - 9.7e-28 97.2 0.0 4.1e-27 95.2 0.0 2.0 2 1 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) ANAPC10 PF03256.16 EDK39030.2 - 7.9e-43 146.2 0.0 1.7e-41 141.9 0.0 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.13 EDK39030.2 - 0.081 13.1 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 PITH domain QRPTase_C PF01729.19 EDK39031.2 - 7.8e-55 185.2 0.1 1.1e-54 184.7 0.1 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EDK39031.2 - 7.4e-21 74.0 0.1 3.6e-20 71.8 0.1 2.2 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain UL40 PF10682.9 EDK39031.2 - 0.01 15.6 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein of human cytomegalovirus HHV-5 Acetyltransf_13 PF13880.6 EDK39032.2 - 8.6e-20 70.5 0.0 1.4e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EDK39032.2 - 9.2e-09 35.0 2.8 2.3e-08 33.7 2.8 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 EDK39032.2 - 0.00064 20.1 0.0 0.0013 19.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDK39032.2 - 0.0012 19.1 0.0 0.0018 18.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK39032.2 - 0.0055 16.6 0.0 0.015 15.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Mito_carr PF00153.27 EDK39033.2 - 2e-30 104.6 8.8 1.1e-10 41.3 0.0 4.7 3 2 0 3 3 3 3 Mitochondrial carrier protein YajC PF02699.15 EDK39033.2 - 0.067 13.1 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Preprotein translocase subunit Rab5ip PF07019.12 EDK39033.2 - 0.098 13.3 0.9 0.46 11.1 0.2 2.4 3 0 0 3 3 3 0 Rab5-interacting protein (Rab5ip) CENP-T_C PF15511.6 EDK39034.2 - 2.7e-08 33.9 0.2 7.9e-08 32.4 0.2 1.7 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold GIDA PF01134.22 EDK39035.2 - 1.3e-148 495.3 0.0 1.7e-148 494.9 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EDK39035.2 - 3.1e-63 213.8 0.0 5.3e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 EDK39035.2 - 9.7e-06 25.0 1.7 0.00017 20.9 0.5 2.5 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDK39035.2 - 0.00079 18.9 0.1 0.0012 18.2 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK39035.2 - 0.012 14.7 0.7 0.02 14.0 0.7 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EDK39035.2 - 0.015 15.9 0.1 0.049 14.2 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK39035.2 - 0.06 12.6 0.0 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK39035.2 - 0.069 12.7 0.8 1.8 8.1 0.4 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase CTNNBL PF08216.11 EDK39035.2 - 0.085 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear HI0933_like PF03486.14 EDK39035.2 - 0.19 10.4 1.5 3 6.4 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein CMS1 PF14617.6 EDK39036.2 - 6.7e-30 104.3 10.3 9.3e-30 103.8 10.3 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EDK39036.2 - 0.024 14.4 1.1 0.027 14.2 0.1 1.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase Vps51 PF08700.11 EDK39038.2 - 1.1e-09 38.2 2.2 3e-09 36.8 0.1 3.0 3 0 0 3 3 3 1 Vps51/Vps67 PMC2NT PF08066.12 EDK39038.2 - 0.21 12.3 0.0 0.21 12.3 0.0 3.3 4 0 0 4 4 4 0 PMC2NT (NUC016) domain Zn_clus PF00172.18 EDK39039.2 - 4.4e-08 33.1 10.4 7.3e-08 32.4 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Synapsin_C PF02750.14 EDK39039.2 - 0.053 13.0 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 Synapsin, ATP binding domain Cse1 PF08506.10 EDK39040.2 - 6.7e-153 508.9 16.1 1.4e-152 507.9 16.1 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EDK39040.2 - 1.7e-101 339.9 0.1 1.7e-101 339.9 0.1 2.4 2 1 1 3 3 3 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EDK39040.2 - 1.6e-16 59.9 0.0 1.7e-15 56.7 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain EamA PF00892.20 EDK39041.1 - 2.6e-06 27.7 32.0 3.8e-05 23.9 9.5 2.3 2 0 0 2 2 2 2 EamA-like transporter family Cellulose_synt PF03552.14 EDK39041.1 - 0.00034 19.2 1.2 0.00065 18.3 1.2 1.4 1 0 0 1 1 1 1 Cellulose synthase PHO4 PF01384.20 EDK39041.1 - 6.9 5.6 23.0 0.012 14.7 4.5 2.8 1 1 0 2 2 2 0 Phosphate transporter family GATase_6 PF13522.6 EDK39042.2 - 2.1e-14 53.9 0.0 4.1e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDK39042.2 - 3.9e-12 46.2 0.0 6.7e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EDK39042.2 - 7.2e-09 35.4 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PSY3 PF16836.5 EDK39042.2 - 0.15 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description PP-binding_2 PF14573.6 EDK39042.2 - 0.22 11.8 1.4 6.4 7.1 0.2 2.5 1 1 1 2 2 2 0 Acyl-carrier DEAD PF00270.29 EDK39043.1 - 1.7e-43 148.4 0.1 2.4e-43 147.9 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39043.1 - 2.3e-29 102.0 0.6 1.6e-28 99.3 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39043.1 - 1.8e-05 24.8 0.0 3.8e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Arcadin_1 PF18653.1 EDK39043.1 - 0.13 12.4 0.0 0.6 10.2 0.0 2.0 2 0 0 2 2 2 0 Arcadin 1 CMS1 PF14617.6 EDK39043.1 - 0.13 11.5 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit EFG_C PF00679.24 EDK39044.2 - 3.3e-15 55.9 0.1 2.4e-14 53.1 0.0 2.5 3 0 0 3 3 3 1 Elongation factor G C-terminus EFG_II PF14492.6 EDK39044.2 - 2.9e-14 52.9 0.0 6.8e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDK39044.2 - 6.7e-09 36.0 0.1 1.4e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RuvB_C PF05491.13 EDK39044.2 - 0.00044 20.1 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 RuvB C-terminal winged helix domain EFG_IV PF03764.18 EDK39044.2 - 0.0098 15.7 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV DUF3801 PF12687.7 EDK39045.2 - 0.00052 20.1 3.6 0.0006 19.9 3.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3801) Papo_T_antigen PF02380.15 EDK39045.2 - 0.052 13.7 0.1 0.092 12.9 0.1 1.4 1 0 0 1 1 1 0 T-antigen specific domain RNase_T PF00929.24 EDK39046.2 - 3e-06 27.9 0.0 5.5e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Adenylsucc_synt PF00709.21 EDK39047.1 - 1.5e-179 597.3 0.0 1.7e-179 597.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF5132 PF17195.4 EDK39047.1 - 0.19 11.9 0.1 0.46 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF5132) Iso_dh PF00180.20 EDK39049.1 - 8.8e-57 192.8 0.0 9.8e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Complex1_LYR_2 PF13233.6 EDK39051.1 - 7.1e-21 74.7 0.5 9.5e-21 74.3 0.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like DSPc PF00782.20 EDK39052.2 - 0.0016 18.3 0.0 1.7 8.5 0.0 2.5 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Hap4_Hap_bind PF10297.9 EDK39053.2 - 2.2e-07 30.8 10.5 2.2e-07 30.8 10.5 2.6 3 0 0 3 3 3 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DASH_Hsk3 PF08227.11 EDK39054.2 - 7.1e-21 74.3 2.5 9.5e-21 73.9 2.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Pet127 PF08634.10 EDK39054.2 - 0.022 14.2 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet127 Cmc1 PF08583.10 EDK39055.1 - 1.7e-19 69.6 5.4 2.1e-19 69.3 5.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Dec-1 PF04624.14 EDK39055.1 - 0.18 11.7 4.4 0.46 10.4 4.4 1.7 1 0 0 1 1 1 0 Dec-1 repeat Spc24 PF08286.11 EDK39056.2 - 1.7e-23 82.8 2.9 1.7e-23 82.8 2.9 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 FAM167 PF11652.8 EDK39056.2 - 0.00048 20.6 1.6 0.39 11.2 0.2 2.4 2 0 0 2 2 2 2 FAM167 Fib_alpha PF08702.10 EDK39056.2 - 1 9.6 4.8 3.2 7.9 0.8 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family L31 PF09784.9 EDK39057.2 - 5e-43 145.7 2.1 5.7e-43 145.5 2.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Ecl1 PF12855.7 EDK39058.2 - 3e-11 44.8 2.1 4e-11 44.4 2.1 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-C2H2_jaz PF12171.8 EDK39058.2 - 0.016 15.5 3.2 0.066 13.5 0.7 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DAGK_prokar PF01219.19 EDK39059.1 - 0.031 14.1 1.6 0.089 12.6 0.1 1.9 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase EI24 PF07264.11 EDK39059.1 - 0.041 14.1 5.2 0.042 14.1 4.3 1.4 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) PWI PF01480.17 EDK39061.2 - 1.2e-06 28.7 0.9 7.9e-06 26.1 0.5 2.4 2 0 0 2 2 2 1 PWI domain Suf PF05843.14 EDK39062.2 - 0.0038 17.3 2.7 3.9 7.4 0.0 4.0 3 2 1 5 5 5 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 EDK39062.2 - 0.02 14.1 7.5 0.099 11.7 0.2 3.7 3 2 1 4 4 4 0 NRDE-2, necessary for RNA interference zf_UBZ PF18439.1 EDK39063.2 - 0.025 14.1 1.7 0.64 9.7 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger C1_1 PF00130.22 EDK39063.2 - 0.038 13.9 0.2 0.078 12.9 0.2 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) UBA PF00627.31 EDK39064.2 - 3.8e-27 93.8 2.3 5.5e-14 51.7 0.3 2.4 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 EDK39064.2 - 4.9e-17 61.4 1.5 8.8e-17 60.6 1.5 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EDK39064.2 - 1.7e-12 46.9 0.5 3.2e-12 46.0 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 EDK39064.2 - 2.6e-05 24.3 0.1 4.9e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 EDK39064.2 - 0.00057 19.7 0.1 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDK39064.2 - 0.0009 19.8 0.1 0.0023 18.5 0.1 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDK39064.2 - 0.0047 17.2 0.6 0.0084 16.4 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Serglycin PF04360.12 EDK39064.2 - 3 7.8 8.7 5.3 7.0 3.3 2.3 2 0 0 2 2 2 0 Serglycin FAM199X PF15814.5 EDK39064.2 - 6.4 5.7 8.0 11 5.0 3.9 2.1 2 0 0 2 2 2 0 Protein family FAM199X DUF3336 PF11815.8 EDK39066.2 - 9e-46 155.0 1.3 1.5e-45 154.3 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDK39066.2 - 1e-16 61.8 0.0 2e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DUF5102 PF17104.5 EDK39067.2 - 1.1e-24 88.0 11.6 2.9e-23 83.4 11.6 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF5102) ADIP PF11559.8 EDK39067.2 - 0.073 13.2 4.0 0.1 12.7 4.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Arteri_nsp7a PF16749.5 EDK39067.2 - 0.11 12.7 0.4 0.17 12.1 0.4 1.2 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha Fungal_trans PF04082.18 EDK39068.2 - 3.4e-28 98.4 0.1 3.4e-28 98.4 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39068.2 - 3.1e-09 36.8 9.5 5.1e-09 36.1 9.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ytca PF17090.5 EDK39068.2 - 0.6 10.7 2.6 0.93 10.0 0.9 2.1 2 0 0 2 2 2 0 Uncharacterised protein family Fungal_trans PF04082.18 EDK39069.2 - 5.8e-17 61.6 0.4 1.1e-16 60.7 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39069.2 - 3.8e-08 33.3 12.2 6.3e-08 32.6 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro-rich_19 PF15455.6 EDK39069.2 - 0.15 11.2 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Proline-rich 19 PALP PF00291.25 EDK39070.2 - 4.1e-65 220.1 0.8 5.6e-65 219.7 0.8 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GHMP_kinases_C PF08544.13 EDK39070.2 - 0.11 12.9 0.0 0.36 11.2 0.0 1.9 1 0 0 1 1 1 0 GHMP kinases C terminal NDUF_B12 PF08122.12 EDK39070.2 - 0.13 12.4 0.9 22 5.2 0.0 2.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Glycos_transf_1 PF00534.20 EDK39071.2 - 0.08 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 PEX11 PF05648.14 EDK39072.2 - 1.5e-05 24.6 1.1 1.9e-05 24.2 1.1 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PEX11 PF05648.14 EDK39073.2 - 0.0048 16.4 0.1 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) Fumble PF03630.14 EDK39074.2 - 4.3e-129 430.4 1.2 5.2e-129 430.1 1.2 1.1 1 0 0 1 1 1 1 Fumble Peptidase_M1 PF01433.20 EDK39075.2 - 1e-43 149.4 0.4 2e-43 148.5 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDK39075.2 - 2.6e-36 125.8 2.5 2.6e-36 125.8 2.5 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDK39075.2 - 9.3e-25 87.9 0.6 2e-24 86.8 0.1 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF3458 PF11940.8 EDK39075.2 - 0.092 13.2 0.3 2.3 8.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3458) Ig-like fold SWM_repeat PF13753.6 EDK39075.2 - 0.1 12.8 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 Putative flagellar system-associated repeat ABC_membrane PF00664.23 EDK39076.2 - 4.7e-40 138.0 16.4 7.6e-40 137.3 16.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDK39076.2 - 6e-34 117.5 0.0 1.1e-33 116.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDK39076.2 - 3.8e-10 39.6 0.7 4.3e-07 29.6 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDK39076.2 - 0.00036 20.9 0.0 0.00077 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDK39076.2 - 0.001 19.4 0.1 0.0039 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EDK39076.2 - 0.0021 17.9 0.1 0.0034 17.2 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 EDK39076.2 - 0.0043 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EDK39076.2 - 0.0057 16.4 0.0 0.012 15.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EDK39076.2 - 0.011 15.6 0.1 0.041 13.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Cytidylate_kin PF02224.18 EDK39076.2 - 0.039 13.7 0.1 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase AAA_24 PF13479.6 EDK39076.2 - 0.053 13.2 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDK39076.2 - 0.055 13.6 0.0 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDK39076.2 - 0.062 12.6 0.1 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_10 PF12846.7 EDK39076.2 - 0.075 11.9 0.7 0.47 9.3 0.0 2.2 2 1 1 3 3 3 0 AAA-like domain AAA_33 PF13671.6 EDK39076.2 - 0.097 12.8 0.0 0.31 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDK39076.2 - 0.11 12.1 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDK39076.2 - 0.19 12.2 1.4 0.51 10.8 0.0 2.3 3 0 0 3 3 2 0 AAA domain TPP_enzyme_N PF02776.18 EDK39077.2 - 5.7e-32 110.7 0.0 1.1e-31 109.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDK39077.2 - 5e-29 100.8 0.0 1.7e-27 95.8 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDK39077.2 - 6.2e-12 45.6 0.0 1.5e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OCC1 PF15506.6 EDK39077.2 - 0.043 13.9 0.2 12 6.1 0.0 2.7 2 0 0 2 2 2 0 OCC1 family HLH PF00010.26 EDK39078.2 - 2.9e-15 56.0 4.5 6.6e-15 54.8 4.5 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RskA PF10099.9 EDK39078.2 - 0.021 15.1 7.4 0.036 14.4 7.4 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA TFIIA PF03153.13 EDK39078.2 - 0.046 13.7 20.1 0.06 13.3 20.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2967 PF11179.8 EDK39078.2 - 1 7.4 16.1 0.5 8.4 14.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2967) DUF2057 PF09829.9 EDK39078.2 - 1.5 8.9 18.7 0.39 10.8 14.6 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF3138 PF11336.8 EDK39078.2 - 1.9 7.0 7.8 2.5 6.6 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) LicD PF04991.13 EDK39079.2 - 2e-29 103.4 3.5 1.9e-26 93.6 1.3 3.8 3 1 1 4 4 4 2 LicD family Xan_ur_permease PF00860.20 EDK39080.1 - 1.5e-69 234.6 28.2 2.9e-69 233.6 28.2 1.4 1 1 0 1 1 1 1 Permease family DUF4029 PF13221.6 EDK39080.1 - 0.011 16.4 0.1 0.03 14.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4029) PEX11 PF05648.14 EDK39081.2 - 0.00073 19.1 2.5 0.073 12.5 0.0 3.0 2 1 1 3 3 3 3 Peroxisomal biogenesis factor 11 (PEX11) Mito_carr PF00153.27 EDK39082.2 - 1e-35 121.5 7.7 5.8e-19 67.8 0.3 2.8 2 1 1 3 3 3 2 Mitochondrial carrier protein PAP2 PF01569.21 EDK39082.2 - 0.022 14.5 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 PAP2 superfamily MutL_C PF08676.11 EDK39083.2 - 1.4e-14 54.1 5.2 5.7e-14 52.1 4.3 2.5 2 1 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 EDK39083.2 - 2.1e-08 34.1 0.3 4.7e-08 33.0 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDK39083.2 - 3.1e-06 27.7 0.1 6.6e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hep_59 PF07052.11 EDK39084.2 - 0.022 15.5 0.5 0.055 14.2 0.5 1.8 1 1 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 NPCC PF08058.11 EDK39085.2 - 3.6e-37 127.3 0.1 6.8e-37 126.4 0.0 1.5 2 0 0 2 2 2 1 Nuclear pore complex component 4HBT_3 PF13622.6 EDK39086.1 - 5.9e-28 98.8 0.0 7.4e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDK39086.1 - 2.8e-08 33.7 1.8 0.00017 21.4 0.3 3.3 3 1 1 4 4 4 2 Acyl-CoA thioesterase Recep_L_domain PF01030.24 EDK39087.2 - 7e-10 39.0 6.7 0.0049 17.0 0.1 3.8 2 1 1 3 3 3 3 Receptor L domain LRR_8 PF13855.6 EDK39087.2 - 0.071 12.9 6.4 4.4 7.1 0.3 4.3 2 1 1 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 EDK39087.2 - 0.23 11.9 20.4 0.69 10.4 0.9 5.2 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) CTP_transf_like PF01467.26 EDK39088.2 - 5.1e-09 36.5 0.0 7.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 EDK39088.2 - 0.027 14.0 0.1 0.053 13.0 0.0 1.5 2 0 0 2 2 2 0 ATP-sulfurylase Pepdidase_M14_N PF18027.1 EDK39089.2 - 0.0075 16.6 0.2 0.14 12.5 0.0 2.3 2 0 0 2 2 2 1 Cytosolic carboxypeptidase N-terminal domain THDPS_N_2 PF14805.6 EDK39089.2 - 0.08 13.2 0.1 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal GREB1 PF15782.5 EDK39089.2 - 0.21 8.6 1.9 0.28 8.3 1.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Cid2 PF09774.9 EDK39090.2 - 0.093 13.2 0.9 0.93 9.9 0.0 2.7 2 1 1 3 3 3 0 Caffeine-induced death protein 2 DUF4112 PF13430.6 EDK39091.2 - 1.3e-29 102.6 0.1 2.1e-29 101.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DHHC PF01529.20 EDK39092.2 - 3e-27 95.4 5.7 3e-27 95.4 5.7 3.0 3 1 0 3 3 3 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EDK39092.2 - 1.7e-25 89.4 0.4 1.3e-12 48.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK39092.2 - 9.3e-23 80.3 5.7 8.3e-07 29.4 0.0 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK39092.2 - 5.7e-18 63.2 2.8 0.0021 18.4 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EDK39092.2 - 1.1e-16 60.4 3.6 0.00081 19.7 0.1 6.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EDK39092.2 - 1.6e-14 53.8 3.8 0.0065 16.8 0.7 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) DUF1129 PF06570.11 EDK39092.2 - 0.09 12.3 2.9 0.22 11.0 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Polysacc_synt_C PF14667.6 EDK39092.2 - 0.4 10.7 9.9 1 9.4 9.9 1.7 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain CHORD PF04968.12 EDK39093.2 - 0.024 15.3 6.3 0.055 14.2 6.3 1.6 1 0 0 1 1 1 0 CHORD MutS_V PF00488.21 EDK39095.2 - 1.5e-63 214.3 0.3 2.4e-63 213.6 0.3 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDK39095.2 - 2.4e-32 112.7 0.0 5.9e-32 111.4 0.0 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EDK39095.2 - 4.5e-31 107.4 0.0 1.3e-30 106.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EDK39095.2 - 1.7e-16 60.8 0.0 7.1e-16 58.7 0.0 2.0 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EDK39095.2 - 8.5e-13 48.5 0.6 2.1e-12 47.2 0.6 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 EDK39095.2 - 0.016 14.8 0.7 0.029 14.0 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDK39095.2 - 0.017 14.8 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CDC45 PF02724.14 EDK39095.2 - 8.4 4.5 12.2 16 3.6 12.2 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF4149 PF13664.6 EDK39096.2 - 2.7e-22 79.0 1.2 1e-21 77.1 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) LANC_like PF05147.13 EDK39096.2 - 0.02 13.5 0.1 0.024 13.2 0.1 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein zf-C2H2 PF00096.26 EDK39097.2 - 7.9e-09 35.5 9.7 0.00051 20.3 2.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK39097.2 - 9.3e-06 25.8 8.5 1.8e-05 24.9 3.9 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK39097.2 - 0.00037 21.1 12.6 0.076 13.9 0.9 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EDK39097.2 - 0.0071 16.7 1.1 1 9.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK39097.2 - 0.076 13.3 0.4 9.3 6.7 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EDK39097.2 - 0.4 10.4 3.1 5.5 6.7 0.1 2.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Glutaredoxin PF00462.24 EDK39098.2 - 1.8e-19 69.7 0.0 1.1e-17 63.9 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EDK39098.2 - 4.8e-14 52.2 0.0 1.5e-13 50.6 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EDK39098.2 - 8.2e-06 26.1 0.1 0.0044 17.3 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDK39098.2 - 0.0022 18.4 0.0 0.026 15.0 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.16 EDK39098.2 - 0.0051 15.8 0.0 0.0078 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosducin OST3_OST6 PF04756.13 EDK39098.2 - 0.077 12.3 0.1 0.088 12.1 0.1 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EDK39098.2 - 0.11 12.3 0.0 0.43 10.4 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin Rad17 PF03215.15 EDK39100.2 - 3.2e-30 105.5 0.0 7.4e-30 104.2 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EDK39100.2 - 2.9e-05 24.5 0.0 4e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EDK39100.2 - 0.0014 19.1 0.0 0.01 16.2 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EDK39100.2 - 0.0087 15.1 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EDK39100.2 - 0.016 15.0 0.0 0.028 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDK39100.2 - 0.063 13.5 0.0 0.35 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDK39100.2 - 0.12 12.8 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase JmjC PF02373.22 EDK39101.2 - 2.2e-41 140.9 0.7 2.2e-41 140.9 0.7 2.9 3 0 0 3 3 3 1 JmjC domain, hydroxylase JmjN PF02375.17 EDK39101.2 - 7.4e-13 48.2 0.5 2.4e-12 46.6 0.5 2.0 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.6 EDK39101.2 - 2.4e-12 46.9 8.0 2.4e-12 46.9 8.0 2.0 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EDK39101.2 - 1.1e-09 38.4 6.1 3.3e-09 36.9 6.1 1.9 1 0 0 1 1 1 1 PHD-zinc-finger like domain Slx4 PF09494.10 EDK39102.2 - 4.9e-17 61.6 0.2 1.3e-16 60.3 0.2 1.7 1 0 0 1 1 1 1 Slx4 endonuclease Talin_middle PF09141.10 EDK39102.2 - 0.084 12.9 0.1 0.084 12.9 0.1 2.0 2 0 0 2 2 2 0 Talin, middle domain CAF1A PF12253.8 EDK39103.2 - 7e-25 87.0 10.3 7e-25 87.0 10.3 4.7 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A DUF966 PF06136.13 EDK39103.2 - 5.8 6.5 34.9 0.56 9.9 30.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Sulfate_transp PF00916.20 EDK39104.2 - 1.8e-114 382.5 16.5 2.4e-114 382.1 16.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDK39104.2 - 1.5e-06 27.8 0.0 3e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 STAS domain YdjM PF04307.14 EDK39104.2 - 1.7 7.9 4.9 4.5 6.5 4.9 1.6 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase FGGY_C PF02782.16 EDK39105.2 - 1.6e-54 184.7 1.0 2e-54 184.3 0.2 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDK39105.2 - 1.3e-23 83.8 0.0 3.5e-23 82.4 0.0 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EDK39105.2 - 0.035 13.6 0.0 0.21 11.1 0.0 2.2 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family CBFD_NFYB_HMF PF00808.23 EDK39106.2 - 1.1e-13 51.2 0.6 1.7e-13 50.6 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK39106.2 - 2.9e-06 27.7 0.0 3.4e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-W PF15510.6 EDK39106.2 - 0.14 12.4 0.1 0.19 12.0 0.1 1.1 1 0 0 1 1 1 0 CENP-W protein tRNA_int_endo PF01974.17 EDK39107.2 - 4.9e-22 77.8 0.3 1.5e-21 76.3 0.1 1.8 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EDK39107.2 - 0.15 11.7 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain APG6 PF04111.12 EDK39108.2 - 4.2e-53 179.9 1.4 6.4e-53 179.4 0.1 1.9 2 0 0 2 2 2 1 Apg6 BARA domain APG6_N PF17675.1 EDK39108.2 - 3.8e-22 79.3 23.8 3.8e-22 79.3 23.8 2.1 2 0 0 2 2 2 1 Apg6 coiled-coil region MoaF PF10703.9 EDK39108.2 - 0.1 12.5 0.1 1.1 9.2 0.2 2.3 2 0 0 2 2 2 0 MoaF N-terminal domain SPT16 PF08644.11 EDK39108.2 - 0.86 9.8 5.1 1.8 8.8 5.1 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DDE_Tnp_ISL3 PF01610.17 EDK39108.2 - 1.7 8.3 9.4 1.9 8.1 8.5 1.5 1 1 0 1 1 1 0 Transposase EMP70 PF02990.16 EDK39109.2 - 6.6e-198 658.6 13.5 1e-197 657.9 13.5 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Zn_clus PF00172.18 EDK39110.2 - 8.7e-08 32.2 9.5 1.6e-07 31.3 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E7R PF17467.2 EDK39110.2 - 0.0085 16.2 3.4 1.5 9.0 0.4 2.6 2 0 0 2 2 2 2 Viral Protein E7 Nop14 PF04147.12 EDK39110.2 - 0.037 12.3 0.3 0.057 11.6 0.3 1.2 1 0 0 1 1 1 0 Nop14-like family BTB_2 PF02214.22 EDK39111.2 - 7.9e-09 35.8 3.1 0.0012 19.2 0.2 3.6 3 1 0 3 3 3 2 BTB/POZ domain Fungal_trans_2 PF11951.8 EDK39112.2 - 6.8e-24 84.4 0.3 9e-24 84.0 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39112.2 - 5.8e-11 42.3 9.4 1.3e-10 41.2 9.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.23 EDK39113.2 - 1.6e-08 34.3 0.1 5.8e-08 32.5 0.1 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EDK39113.2 - 0.002 18.0 0.8 0.041 13.7 0.4 2.6 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase MFS_1 PF07690.16 EDK39114.2 - 2.6e-25 89.1 27.4 4.3e-25 88.4 27.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK39114.2 - 2.9e-05 23.1 12.3 2.9e-05 23.1 12.3 2.2 1 1 1 2 2 2 1 Sugar (and other) transporter PMP1_2 PF08114.11 EDK39114.2 - 0.076 12.8 0.8 0.21 11.4 0.8 1.7 1 0 0 1 1 1 0 ATPase proteolipid family ATP-synt_C PF00137.21 EDK39115.2 - 3.1e-26 91.5 31.3 1.4e-15 57.4 13.2 2.4 2 0 0 2 2 2 2 ATP synthase subunit C DUF3671 PF12420.8 EDK39115.2 - 0.89 9.7 3.7 0.52 10.4 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function RPN1_RPN2_N PF17781.1 EDK39116.2 - 4.3e-112 374.5 3.9 9.4e-112 373.4 3.9 1.6 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EDK39116.2 - 9.7e-27 92.8 0.1 1.8e-26 91.9 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EDK39116.2 - 1.4e-24 85.2 12.6 1e-06 28.9 0.1 9.2 9 0 0 9 9 9 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDK39116.2 - 5.3e-08 33.1 0.0 0.012 16.0 0.0 3.6 3 1 0 3 3 3 2 HEAT repeats Zip PF02535.22 EDK39116.2 - 0.15 11.2 1.4 0.27 10.4 0.1 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Raftlin PF15250.6 EDK39116.2 - 4.6 5.9 8.0 0.13 11.0 1.3 1.7 2 0 0 2 2 2 0 Raftlin DUF913 PF06025.12 EDK39116.2 - 6.5 5.6 13.9 0.047 12.7 2.8 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CENP-B_dimeris PF09026.10 EDK39116.2 - 9.1 6.7 11.6 7.7 7.0 1.0 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CRAL_TRIO_2 PF13716.6 EDK39117.2 - 2.1e-15 57.1 0.9 4.7e-15 55.9 0.9 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EDK39117.2 - 3.3e-12 46.5 0.1 7.8e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Intimin_C PF07979.11 EDK39117.2 - 0.11 12.9 0.1 0.25 11.8 0.1 1.6 1 0 0 1 1 1 0 Intimin C-type lectin domain AFT PF08731.11 EDK39118.2 - 5.5e-06 26.8 1.8 1.7e-05 25.2 0.2 2.6 2 1 0 2 2 2 1 Transcription factor AFT FAR1 PF03101.15 EDK39118.2 - 0.00036 21.2 1.3 0.00036 21.2 1.3 2.0 2 0 0 2 2 2 1 FAR1 DNA-binding domain Spermine_synth PF01564.17 EDK39120.2 - 5.7e-56 188.9 0.1 9.1e-56 188.2 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDK39120.2 - 1.9e-23 82.1 0.1 4.5e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_31 PF13847.6 EDK39120.2 - 0.0018 18.1 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3764 PF12594.8 EDK39120.2 - 0.011 15.8 0.0 0.31 11.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) Pyr_redox_2 PF07992.14 EDK39120.2 - 0.022 14.0 0.0 0.031 13.5 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Cons_hypoth95 PF03602.15 EDK39120.2 - 0.03 14.0 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CRM1_repeat_2 PF18784.1 EDK39120.2 - 0.053 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 zf-C2H2 PF00096.26 EDK39121.2 - 5.1e-05 23.5 17.5 0.00015 22.0 4.1 3.8 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK39121.2 - 6.1e-05 23.5 15.1 0.0011 19.6 2.0 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK39121.2 - 0.0036 17.7 13.2 0.037 14.5 1.9 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zinc_ribbon_5 PF13719.6 EDK39121.2 - 0.37 10.6 1.8 0.98 9.2 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EDK39121.2 - 0.79 9.9 6.5 12 6.2 0.7 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 EDK39121.2 - 1.7 9.0 6.8 35 4.8 5.8 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding BrkDBD PF09607.10 EDK39122.2 - 0.074 12.8 0.7 0.15 11.9 0.7 1.5 1 0 0 1 1 1 0 Brinker DNA-binding domain TPR_14 PF13428.6 EDK39123.2 - 4e-05 24.1 1.2 0.39 11.7 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDK39123.2 - 0.00083 19.8 6.3 1 9.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDK39123.2 - 0.0049 17.0 0.0 8.7 6.8 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK39123.2 - 0.036 14.2 0.0 16 5.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK39123.2 - 0.13 12.9 1.2 0.75 10.5 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Tox-HDC PF15656.6 EDK39123.2 - 0.16 12.2 1.3 2.5 8.3 0.1 2.3 2 0 0 2 2 2 0 Toxin with a H, D/N and C signature ANAPC3 PF12895.7 EDK39123.2 - 0.43 10.8 2.8 5.1 7.4 0.1 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Fungal_trans PF04082.18 EDK39124.2 - 9.3e-05 21.6 0.7 0.00027 20.0 0.7 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39124.2 - 0.0033 17.5 11.1 0.006 16.7 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.12 EDK39125.2 - 3.9e-37 128.3 31.8 4.6e-37 128.1 31.8 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 EDK39125.2 - 0.79 8.2 35.0 1.1 7.8 35.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GIT_SHD PF08518.11 EDK39126.2 - 3.5e-25 87.3 4.9 4.5e-13 48.6 0.7 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 EDK39126.2 - 8.9e-07 29.0 2.4 8.9e-07 29.0 2.4 3.4 2 1 1 3 3 3 1 G protein-coupled receptor kinase-interacting protein 1 C term Pentapeptide_4 PF13599.6 EDK39126.2 - 0.054 13.7 4.1 0.76 10.0 0.6 2.8 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) HC2 PF07382.11 EDK39126.2 - 0.11 12.5 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 MSV199 PF10553.9 EDK39126.2 - 4 7.7 6.7 5.9 7.2 2.9 3.0 2 0 0 2 2 2 0 MSV199 domain DEAD PF00270.29 EDK39127.2 - 9.2e-41 139.5 0.8 1.6e-40 138.8 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39127.2 - 3e-28 98.4 0.0 3e-28 98.4 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39127.2 - 2.2e-05 24.5 0.0 2.2e-05 24.5 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDK39127.2 - 0.007 16.6 0.1 0.032 14.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain WSC PF01822.19 EDK39127.2 - 1.8 8.8 4.9 1.7 8.9 2.0 2.4 2 1 0 2 2 2 0 WSC domain Ribonucleas_3_3 PF14622.6 EDK39128.2 - 5.2e-28 97.8 0.1 7e-28 97.4 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EDK39128.2 - 0.0019 18.8 0.0 0.0036 17.9 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain ATP-synt_G PF04718.15 EDK39129.1 - 6.2e-31 107.2 0.3 6.2e-31 107.2 0.3 1.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Serinc PF03348.15 EDK39130.2 - 1.9e-140 468.6 14.1 2.1e-140 468.5 14.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Mpv17_PMP22 PF04117.12 EDK39130.2 - 0.022 15.0 2.8 0.022 15.0 2.8 2.4 2 0 0 2 2 2 0 Mpv17 / PMP22 family PAXNEB PF05625.11 EDK39131.2 - 2.8e-94 316.3 0.1 3.7e-94 315.9 0.1 1.1 1 0 0 1 1 1 1 PAXNEB protein ATPase PF06745.13 EDK39131.2 - 0.056 12.8 0.1 0.57 9.5 0.0 2.3 2 1 0 2 2 2 0 KaiC MCM PF00493.23 EDK39132.2 - 1.6e-101 338.1 0.0 2.6e-101 337.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDK39132.2 - 3.6e-38 130.3 0.4 7.3e-38 129.3 0.4 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDK39132.2 - 3.2e-29 101.2 2.7 9.1e-29 99.7 2.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDK39132.2 - 2.4e-20 73.0 0.9 2.4e-20 73.0 0.9 2.5 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.14 EDK39132.2 - 2.1e-06 27.8 0.0 9.1e-06 25.7 0.0 2.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDK39132.2 - 4.3e-06 26.3 0.0 0.00022 20.7 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDK39132.2 - 8e-05 22.5 0.0 0.0021 17.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PheRS_DBD1 PF18552.1 EDK39132.2 - 0.027 14.2 0.2 0.14 11.9 0.5 2.1 2 0 0 2 2 2 0 PheRS DNA binding domain 1 AAA_16 PF13191.6 EDK39132.2 - 0.033 14.6 0.4 0.71 10.2 0.1 2.9 2 1 1 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.26 EDK39132.2 - 0.058 13.1 0.2 3.2 7.4 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF5321 PF17254.2 EDK39133.2 - 3.6e-09 36.2 0.2 4.3e-09 36.0 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5321) DUF1751 PF08551.10 EDK39134.1 - 6.7e-14 52.3 1.7 6.7e-14 52.3 1.7 2.4 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EDK39134.1 - 0.0066 16.5 3.9 0.015 15.3 3.9 1.6 1 0 0 1 1 1 1 Rhomboid family YWFCY PF14293.6 EDK39134.1 - 3.7 7.9 5.7 0.57 10.5 0.9 2.1 2 0 0 2 2 2 0 YWFCY protein TRAPPC-Trs85 PF12739.7 EDK39135.2 - 9.9e-100 334.3 7.8 9.9e-100 334.3 7.8 1.6 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Rax2 PF12768.7 EDK39136.2 - 2.6e-58 197.0 0.5 2.6e-58 197.0 0.5 6.2 4 3 1 6 6 6 2 Cortical protein marker for cell polarity Reg_prop PF07494.11 EDK39136.2 - 0.039 14.2 0.1 2.1 8.8 0.0 3.8 3 0 0 3 3 3 0 Two component regulator propeller Sortilin_C PF15901.5 EDK39137.2 - 5.2e-46 157.1 7.3 7.1e-46 156.6 7.3 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 EDK39137.2 - 3.4e-35 121.7 0.6 5e-35 121.2 0.6 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.13 EDK39137.2 - 0.056 13.4 0.1 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR PF02012.20 EDK39137.2 - 0.36 11.0 1.9 8.7 6.8 0.1 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EDK39138.2 - 1.1e-186 621.0 15.5 4.3e-103 345.5 5.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDK39138.2 - 7.8e-31 107.7 13.0 2.2e-30 106.3 13.0 1.8 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDK39138.2 - 7e-09 34.4 37.1 0.0079 16.0 0.5 10.5 10 0 0 10 10 10 4 BNR/Asp-box repeat PSII_BNR PF14870.6 EDK39138.2 - 0.00016 21.1 1.1 2.9 7.1 0.2 4.2 3 2 0 3 3 3 2 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.6 EDK39138.2 - 0.00067 19.0 2.0 0.058 12.7 0.0 4.6 4 2 1 5 5 5 1 BNR repeat-like domain Frataxin_Cyay PF01491.16 EDK39138.2 - 0.011 15.8 0.1 0.42 10.7 0.0 3.4 4 0 0 4 4 4 0 Frataxin-like domain DUF4988 PF16378.5 EDK39138.2 - 0.046 13.4 0.2 0.3 10.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function FF PF01846.19 EDK39140.2 - 1.2e-27 95.8 22.4 1.7e-10 40.9 0.8 5.9 6 0 0 6 6 6 4 FF domain WW PF00397.26 EDK39140.2 - 5.6e-18 64.7 22.5 5.2e-09 36.0 7.8 2.6 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 EDK39140.2 - 0.42 10.9 6.9 2.2 8.6 0.4 2.8 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Tae4 PF14113.6 EDK39140.2 - 0.76 10.0 6.8 1.1 9.5 0.2 3.1 2 2 1 3 3 3 0 Type VI secretion system (T6SS), amidase effector protein 4 DUF4047 PF13256.6 EDK39140.2 - 5.4 7.2 10.8 1.3 9.3 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4047) ARPC4 PF05856.12 EDK39141.1 - 3.4e-69 231.7 5.1 3.8e-69 231.6 5.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.5 EDK39141.1 - 0.04 14.1 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 Sm_like domain Fungal_trans PF04082.18 EDK39142.2 - 9.3e-28 97.0 0.2 9.3e-28 97.0 0.2 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39142.2 - 3.6e-05 23.8 10.0 8.1e-05 22.7 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4534 PF15049.6 EDK39143.2 - 0.0021 17.9 0.9 0.0035 17.1 0.8 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4534) DHHC PF01529.20 EDK39144.2 - 7.8e-31 107.0 13.6 7.8e-31 107.0 13.6 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF3176 PF11374.8 EDK39144.2 - 0.31 11.3 2.4 0.35 11.1 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3176) TRM PF02005.16 EDK39146.2 - 5.2e-131 437.3 0.0 6.5e-131 437.0 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EDK39146.2 - 0.00034 20.4 0.0 0.00092 19.0 0.0 1.7 1 0 0 1 1 1 1 Met-10+ like-protein DUF2067 PF09840.9 EDK39146.2 - 0.0055 16.3 0.0 0.013 15.1 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) Thg1C PF14413.6 EDK39146.2 - 0.02 15.1 1.2 0.11 12.7 0.1 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain DUF655 PF04919.12 EDK39146.2 - 0.051 13.5 0.2 0.42 10.5 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF655) YjbE PF11106.8 EDK39147.1 - 0.72 10.1 29.1 0.48 10.7 9.7 2.0 1 1 1 2 2 2 0 Exopolysaccharide production protein YjbE Period_C PF12114.8 EDK39147.1 - 1.2 8.7 5.5 1.3 8.6 5.5 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region TraT PF05818.12 EDK39147.1 - 4.9 6.8 12.8 5.6 6.6 12.8 1.0 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Epimerase PF01370.21 EDK39148.2 - 1.1e-16 61.0 0.0 2e-16 60.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK39148.2 - 1.6e-12 47.0 0.0 2e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK39148.2 - 2.5e-10 40.5 0.0 4.7e-10 39.7 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK39148.2 - 6.6e-09 35.3 0.1 5e-06 25.9 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK39148.2 - 0.00031 20.3 0.0 0.0021 17.6 0.1 2.2 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDK39148.2 - 0.0013 18.0 0.3 0.0019 17.4 0.3 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EDK39148.2 - 0.0018 17.9 0.1 0.078 12.5 0.1 2.3 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDK39148.2 - 0.0059 16.1 0.3 0.021 14.3 0.0 2.1 2 1 0 2 2 2 1 short chain dehydrogenase Shikimate_DH PF01488.20 EDK39148.2 - 0.018 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 EDK39148.2 - 0.083 12.6 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ydc2-catalyt PF09159.10 EDK39149.1 - 6.5e-49 167.2 0.5 1e-48 166.5 0.5 1.3 1 1 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Flavoprotein PF02441.19 EDK39150.2 - 2.4e-53 180.1 0.5 3.6e-53 179.5 0.5 1.3 1 0 0 1 1 1 1 Flavoprotein DNA_pol_phi PF04931.13 EDK39150.2 - 0.00066 17.9 25.9 0.00095 17.4 25.9 1.1 1 0 0 1 1 1 1 DNA polymerase phi Pox_Ag35 PF03286.14 EDK39150.2 - 0.011 15.5 7.4 0.04 13.7 7.4 1.9 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DARPP-32 PF05395.12 EDK39150.2 - 0.2 11.9 8.2 0.53 10.5 8.2 1.6 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Utp14 PF04615.13 EDK39150.2 - 0.4 9.2 16.3 0.68 8.4 16.3 1.3 1 0 0 1 1 1 0 Utp14 protein TFB6 PF17110.5 EDK39150.2 - 0.58 9.9 10.3 1.3 8.7 10.3 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Sigma70_ner PF04546.13 EDK39150.2 - 0.75 9.6 18.5 1.3 8.8 18.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Slu7 PF11708.8 EDK39150.2 - 0.89 9.3 13.5 3 7.5 13.5 1.8 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor Afi1 PF07792.12 EDK39150.2 - 1.4 9.4 12.2 3.9 7.9 12.2 1.7 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BUD22 PF09073.10 EDK39150.2 - 1.6 8.0 17.7 3.3 7.0 17.7 1.4 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EDK39150.2 - 3.3 5.8 24.0 5.1 5.2 24.0 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDK39150.2 - 5.1 5.3 20.2 8.1 4.6 20.2 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EDK39150.2 - 6.8 5.9 30.0 12 5.1 30.0 1.3 1 0 0 1 1 1 0 NOA36 protein Peptidase_S24 PF00717.23 EDK39151.2 - 1.1e-08 34.9 0.1 1.7e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like adh_short PF00106.25 EDK39152.2 - 7.4e-38 130.0 0.0 1e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39152.2 - 6.4e-26 91.4 0.0 8.3e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK39152.2 - 0.00011 22.2 0.1 0.0002 21.3 0.1 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK39152.2 - 0.0026 17.7 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 EDK39152.2 - 0.012 14.9 0.0 0.14 11.5 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 EDK39152.2 - 0.027 14.9 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 EDK39152.2 - 0.039 13.6 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DFP PF04127.15 EDK39152.2 - 0.042 13.7 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Pyr_redox PF00070.27 EDK39152.2 - 0.082 13.5 0.0 0.28 11.8 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 EDK39152.2 - 0.1 12.1 0.1 0.15 11.5 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PRKCSH-like PF12999.7 EDK39155.2 - 2.8e-84 281.3 6.3 6.2e-84 280.1 6.3 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EDK39155.2 - 3.7e-60 202.1 0.1 3.7e-60 202.1 0.1 2.2 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein Fib_alpha PF08702.10 EDK39155.2 - 6.9e-05 23.1 8.4 6.9e-05 23.1 8.4 2.1 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 EDK39155.2 - 0.0074 15.9 5.4 0.011 15.4 5.4 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EDK39155.2 - 0.015 13.2 8.0 0.02 12.8 8.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliJ PF02050.16 EDK39155.2 - 0.042 14.1 7.0 0.033 14.4 3.3 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein Apolipoprotein PF01442.18 EDK39155.2 - 0.051 13.5 6.2 0.08 12.8 6.2 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF4407 PF14362.6 EDK39155.2 - 1.2 8.4 5.6 2 7.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rx_N PF18052.1 EDK39155.2 - 1.2 9.4 4.7 8.2 6.8 2.2 2.5 1 1 1 2 2 2 0 Rx N-terminal domain TMPIT PF07851.13 EDK39155.2 - 1.4 8.1 14.1 0.88 8.8 12.0 1.7 1 1 1 2 2 2 0 TMPIT-like protein DUF2203 PF09969.9 EDK39155.2 - 1.8 9.3 5.5 0.94 10.2 2.7 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Prominin PF05478.11 EDK39155.2 - 2.6 5.9 9.7 2.2 6.1 8.3 1.5 1 1 0 1 1 1 0 Prominin LUC7 PF03194.15 EDK39155.2 - 3.4 7.3 10.4 6.8 6.3 10.4 1.5 1 1 0 1 1 1 0 LUC7 N_terminus Baculo_PEP_C PF04513.12 EDK39155.2 - 3.7 7.6 6.2 16 5.5 6.1 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4047 PF13256.6 EDK39155.2 - 7.7 6.7 8.4 2.2 8.5 1.3 2.9 2 1 2 4 4 4 0 Domain of unknown function (DUF4047) BUD22 PF09073.10 EDK39156.2 - 4.3e-62 210.9 40.7 1.5e-49 169.5 31.9 2.2 1 1 1 2 2 2 2 BUD22 Trypan_PARP PF05887.11 EDK39156.2 - 0.00022 21.2 2.0 0.00022 21.2 2.0 1.7 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF5118 PF17162.4 EDK39156.2 - 0.078 12.8 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) TRM13 PF05206.14 EDK39157.2 - 2.5e-74 250.1 4.2 2.2e-62 211.0 0.6 2.1 1 1 1 2 2 2 2 Methyltransferase TRM13 TCTP PF00838.17 EDK39158.2 - 4.7e-73 245.0 1.5 5.9e-73 244.7 1.5 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein GerPC PF10737.9 EDK39158.2 - 0.094 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Spore germination protein GerPC DPPIV_N PF00930.21 EDK39159.2 - 4.3e-105 351.4 10.3 7e-105 350.7 10.3 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDK39159.2 - 1.2e-45 155.6 0.6 2e-45 154.9 0.6 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EDK39159.2 - 0.0005 20.7 0.1 0.0083 16.8 0.1 2.4 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EDK39159.2 - 0.0031 17.1 0.5 0.011 15.4 0.4 1.9 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 EDK39159.2 - 0.015 15.1 0.0 1.3 8.7 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DLH PF01738.18 EDK39159.2 - 0.032 13.8 0.0 0.083 12.4 0.0 1.6 1 1 0 1 1 1 0 Dienelactone hydrolase family COesterase PF00135.28 EDK39159.2 - 0.034 13.0 0.0 0.079 11.8 0.0 1.5 1 0 0 1 1 1 0 Carboxylesterase family AXE1 PF05448.12 EDK39159.2 - 0.049 12.3 0.0 0.53 8.9 0.0 2.2 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Response_reg PF00072.24 EDK39160.2 - 3.2e-27 94.9 0.2 6.7e-27 93.9 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EDK39160.2 - 2.1e-24 86.2 0.0 2.3e-19 69.9 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EDK39160.2 - 8.1e-15 54.6 0.4 2.2e-14 53.2 0.4 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Candida_ALS PF05792.13 EDK39161.2 - 3.4e-280 904.0 1115.5 1.7e-09 38.0 23.9 47.3 46 1 0 46 46 46 44 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.8 EDK39161.2 - 6.1e-78 261.5 7.5 6.1e-78 261.5 7.5 2.5 2 0 0 2 2 2 1 Cell-wall agglutinin N-terminal ligand-sugar binding Hpr_kinase_C PF07475.12 EDK39161.2 - 0.16 11.5 4.5 8.2 5.9 0.0 5.9 6 2 2 8 8 8 0 HPr Serine kinase C-terminal domain Epimerase PF01370.21 EDK39163.2 - 3.7e-15 56.0 0.0 5e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK39163.2 - 1.2e-12 47.4 0.0 1.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK39163.2 - 1.1e-05 25.4 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK39163.2 - 0.00012 21.3 0.1 0.053 12.7 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EDK39163.2 - 0.022 14.3 0.1 0.51 9.9 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family GDP_Man_Dehyd PF16363.5 EDK39163.2 - 0.045 13.1 0.2 0.099 12.0 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans PF04082.18 EDK39165.2 - 3.3e-34 118.1 1.9 4.1e-34 117.8 1.9 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF772 PF05598.11 EDK39165.2 - 0.12 12.4 0.2 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Transposase domain (DUF772) SGL PF08450.12 EDK39166.1 - 7.6e-57 192.7 0.1 9.1e-57 192.5 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EDK39166.1 - 0.0014 18.7 0.0 0.0036 17.4 0.0 1.7 1 0 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 EDK39166.1 - 0.0023 17.9 0.0 0.0078 16.2 0.0 2.0 1 0 0 1 1 1 1 NHL repeat Ribul_P_3_epim PF00834.19 EDK39166.1 - 0.21 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family GFO_IDH_MocA PF01408.22 EDK39167.2 - 5.8e-05 23.9 0.0 0.00013 22.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDK39167.2 - 0.002 18.1 0.0 0.0047 16.9 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain IL17R_fnIII_D2 PF16578.5 EDK39167.2 - 0.079 13.5 0.2 0.36 11.4 0.0 2.1 3 0 0 3 3 3 0 Interleukin 17 receptor D MFS_1 PF07690.16 EDK39168.1 - 7.3e-14 51.4 22.0 9.1e-14 51.1 22.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDK39168.1 - 7.7e-11 42.0 11.2 7.7e-11 42.0 11.2 2.2 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 DUF2568 PF10823.8 EDK39168.1 - 1.6 9.1 7.8 3.3 8.1 7.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2568) Abhydrolase_3 PF07859.13 EDK39170.2 - 0.0036 17.2 1.3 0.0062 16.4 1.3 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDK39170.2 - 0.012 14.6 0.1 0.026 13.4 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase COesterase PF00135.28 EDK39170.2 - 0.21 10.4 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family Abhydrolase_3 PF07859.13 EDK39171.2 - 1.4e-52 178.6 0.0 1.5e-52 178.5 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDK39171.2 - 0.0037 16.8 0.7 0.017 14.6 0.7 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Asp PF00026.23 EDK39172.2 - 1.2e-53 182.6 2.2 1.5e-53 182.3 2.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK39172.2 - 1.4e-08 35.2 0.1 4.4e-05 23.8 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDK39172.2 - 0.00081 20.0 0.6 1.5 9.5 0.1 2.9 2 1 0 2 2 2 2 Aspartyl protease MFS_1 PF07690.16 EDK39173.2 - 8.8e-32 110.4 29.8 8.8e-32 110.4 29.8 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK39173.2 - 0.00033 19.2 1.1 0.00067 18.2 1.1 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDK39173.2 - 0.0029 16.0 3.3 0.0029 16.0 3.3 1.9 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family ESSS PF10183.9 EDK39173.2 - 0.016 15.4 0.1 9.8 6.4 0.1 2.4 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF89 PF01937.19 EDK39173.2 - 0.23 10.4 0.1 0.34 9.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 Fungal_trans PF04082.18 EDK39174.2 - 8e-12 44.7 5.7 1.4e-11 43.9 5.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39174.2 - 2.6e-09 37.1 11.2 6.8e-09 35.7 11.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EDK39175.2 - 1.7e-29 102.8 40.7 1.7e-29 102.8 40.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 EDK39176.1 - 1.7e-43 148.1 0.0 8.4e-43 145.8 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDK39176.1 - 1.9e-19 69.7 0.0 2.5e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 EDK39176.1 - 0.0047 17.0 0.0 0.21 11.6 0.0 2.8 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DUF4336 PF14234.6 EDK39177.2 - 0.0014 17.9 0.0 0.43 9.7 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) Porin_OmpG PF09381.10 EDK39177.2 - 0.031 14.0 0.0 0.045 13.5 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein G (OmpG) GST_N PF02798.20 EDK39178.1 - 1.6e-15 57.2 0.0 8.4e-15 54.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDK39178.1 - 3.2e-13 49.9 0.0 6.1e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDK39178.1 - 4e-11 43.1 0.0 8.7e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDK39178.1 - 8.1e-10 38.8 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDK39178.1 - 9.2e-08 32.2 0.0 1.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDK39178.1 - 0.0017 19.0 0.0 0.008 16.9 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EDK39178.1 - 0.099 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Arylsulfotran_2 PF14269.6 EDK39180.2 - 0.14 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) DUF3042 PF11240.8 EDK39180.2 - 1.2 9.2 3.7 0.55 10.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) cobW PF02492.19 EDK39181.1 - 6.4e-47 159.4 7.7 1.1e-44 152.1 7.7 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EDK39181.1 - 1.3e-19 69.9 0.0 1.5e-14 53.6 0.0 2.5 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain SDA1 PF05285.12 EDK39181.1 - 0.0024 17.4 6.2 0.004 16.6 6.2 1.4 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 EDK39181.1 - 0.0041 16.5 3.1 0.0055 16.1 3.1 1.3 1 0 0 1 1 1 1 BUD22 CDC45 PF02724.14 EDK39181.1 - 0.0075 14.6 5.8 0.011 14.1 5.8 1.1 1 0 0 1 1 1 1 CDC45-like protein MeaB PF03308.16 EDK39181.1 - 0.0078 15.2 2.9 0.7 8.8 0.6 2.8 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EDK39181.1 - 0.0097 15.8 0.5 0.02 14.8 0.5 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EDK39181.1 - 0.015 15.7 0.0 0.032 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EDK39181.1 - 0.045 13.8 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Nop14 PF04147.12 EDK39181.1 - 0.06 11.6 12.5 0.083 11.1 12.5 1.1 1 0 0 1 1 1 0 Nop14-like family Viral_helicase1 PF01443.18 EDK39181.1 - 0.078 12.7 0.9 0.37 10.5 0.1 2.4 2 1 1 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 EDK39181.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK39181.1 - 0.13 12.0 0.4 0.31 10.8 0.1 1.7 2 0 0 2 2 1 0 P-loop containing region of AAA domain Sigma70_ner PF04546.13 EDK39181.1 - 0.16 11.8 8.9 0.38 10.6 8.9 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region PTPRCAP PF15713.5 EDK39181.1 - 0.27 11.5 12.5 0.64 10.3 12.5 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GEN1_C PF18380.1 EDK39181.1 - 0.33 11.9 4.9 0.85 10.5 4.9 1.7 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Paf1 PF03985.13 EDK39181.1 - 0.63 9.0 12.3 0.99 8.3 12.3 1.2 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.13 EDK39181.1 - 0.8 7.7 18.5 1.3 7.0 18.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EDK39181.1 - 1.8 7.8 16.3 3.3 7.0 16.3 1.3 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 EDK39181.1 - 3.5 7.3 9.3 8.4 6.0 9.3 1.6 1 0 0 1 1 1 0 FAM176 family MFS_1 PF07690.16 EDK39182.2 - 9.6e-33 113.5 24.9 9.6e-33 113.5 24.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EDK39183.2 - 7.3e-75 251.4 1.4 1.1e-74 250.9 1.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDK39183.2 - 4.2e-06 26.9 7.8 0.0046 17.4 2.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK39183.2 - 0.0002 21.9 6.5 0.016 16.0 1.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EDK39183.2 - 0.00086 19.9 3.1 0.15 12.7 0.2 2.5 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 EDK39183.2 - 0.037 14.5 0.4 0.037 14.5 0.4 3.1 3 0 0 3 3 3 0 Zinc-finger double domain Abhydrolase_3 PF07859.13 EDK39185.1 - 2.6e-60 203.9 0.0 3.5e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDK39185.1 - 1.9e-05 24.3 0.1 0.00024 20.7 0.1 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EDK39185.1 - 2e-05 23.7 0.5 0.00011 21.3 0.5 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EDK39185.1 - 0.00036 19.5 0.0 0.00056 18.9 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Esterase_phd PF10503.9 EDK39185.1 - 0.012 15.2 0.0 0.038 13.5 0.0 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase Fucose_iso_N1 PF07881.12 EDK39185.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 L-fucose isomerase, first N-terminal domain D-ser_dehydrat PF14031.6 EDK39186.2 - 6.4e-22 78.0 0.0 1.4e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EDK39186.2 - 3.5e-14 53.0 0.4 4.8e-14 52.5 0.4 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHDPS PF00701.22 EDK39189.2 - 5.8e-40 136.8 0.0 6.6e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family STALD PF18185.1 EDK39189.2 - 0.1 12.0 0.0 0.38 10.1 0.0 1.9 2 0 0 2 2 2 0 Sir2- and TIR-associating SLOG family GreA_GreB_N PF03449.15 EDK39189.2 - 0.1 12.8 0.2 38 4.5 0.1 3.1 3 0 0 3 3 3 0 Transcription elongation factor, N-terminal Glyco_hydro81C PF17652.1 EDK39190.2 - 1.7e-149 497.8 10.3 2.9e-149 497.1 10.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDK39190.2 - 1.6e-91 306.8 12.6 1.6e-91 306.8 12.6 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain Fer2_3 PF13085.6 EDK39191.2 - 4.9e-32 110.2 0.1 8.1e-32 109.5 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDK39191.2 - 1.7e-09 38.1 8.3 1.7e-09 38.1 8.3 2.1 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDK39191.2 - 5.4e-08 33.2 9.0 5.4e-08 33.2 9.0 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDK39191.2 - 1.2e-07 31.7 4.1 1.2e-07 31.7 4.1 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDK39191.2 - 0.00043 20.8 5.2 0.00043 20.8 5.2 2.6 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EDK39191.2 - 0.0031 17.4 4.0 0.012 15.6 1.2 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 EDK39191.2 - 0.32 11.2 14.3 0.14 12.3 9.2 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain 2-Hacid_dh_C PF02826.19 EDK39192.2 - 3.3e-43 147.1 0.0 1.6e-42 144.8 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDK39192.2 - 8.9e-20 70.7 0.0 1.3e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 EDK39192.2 - 0.01 15.9 0.0 0.86 9.7 0.0 2.6 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Flo11 PF10182.9 EDK39193.2 - 3.3e-32 111.7 3.4 5.8e-32 110.9 3.4 1.3 1 0 0 1 1 1 1 Flo11 domain DUF2087 PF09860.9 EDK39193.2 - 0.014 15.6 0.0 1.1e+02 3.0 0.0 5.3 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2087) SL4P PF17618.2 EDK39193.2 - 0.097 12.7 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein CinA_KH PF18146.1 EDK39194.1 - 0.65 10.2 5.2 46 4.3 0.0 3.9 3 2 2 5 5 5 0 Damage-inducible protein CinA KH domain FTH PF01827.27 EDK39196.2 - 0.0065 16.3 2.6 1.8 8.4 0.6 2.9 2 0 0 2 2 2 2 FTH domain DUF4277 PF14104.6 EDK39197.2 - 0.084 13.2 0.0 3.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4277) Zn_clus PF00172.18 EDK39198.2 - 5e-08 32.9 11.2 5e-08 32.9 11.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EDK39199.2 - 1.9e-70 236.7 11.5 1.9e-70 236.7 11.5 1.6 2 0 0 2 2 2 1 RTA1 like protein DctQ PF04290.12 EDK39199.2 - 3.3 7.6 13.6 2.7 7.9 1.9 3.2 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component GWT1 PF06423.12 EDK39199.2 - 7 6.8 10.7 0.64 10.1 3.2 2.4 2 1 1 3 3 3 0 GWT1 DUF3112 PF11309.8 EDK39199.2 - 9.3 5.6 14.1 0.14 11.6 3.3 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF3112) Sugar_tr PF00083.24 EDK39201.1 - 1.1e-32 113.5 9.5 1.3e-32 113.2 9.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39201.1 - 1.2e-12 47.4 14.5 2e-12 46.7 14.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily PAP2 PF01569.21 EDK39202.2 - 2.3e-22 79.2 1.9 2.7e-22 79.0 0.8 1.6 2 0 0 2 2 2 1 PAP2 superfamily IL34 PF15036.6 EDK39202.2 - 0.12 12.4 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 Interleukin 34 S-AdoMet_synt_C PF02773.16 EDK39203.1 - 8e-67 223.5 0.2 1.8e-66 222.3 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EDK39203.1 - 4.3e-46 156.1 0.0 7.7e-46 155.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EDK39203.1 - 4e-44 149.3 0.2 8.7e-44 148.3 0.2 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EDK39203.1 - 0.046 12.5 0.3 0.16 10.7 0.2 1.8 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) MRC1 PF09444.10 EDK39204.2 - 2.5e-33 115.6 14.6 2.5e-33 115.6 14.6 6.6 6 1 0 6 6 6 2 MRC1-like domain TFIIB_C_1 PF18542.1 EDK39205.2 - 0.09 12.8 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Transcription factor IIB C-terminal module 1 tRNA_synt_1c_R2 PF04557.15 EDK39205.2 - 0.11 13.4 1.2 11 7.0 0.0 2.8 3 0 0 3 3 3 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 KH_8 PF17903.1 EDK39206.1 - 9.2e-33 112.2 0.1 1.9e-32 111.2 0.1 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDK39206.1 - 0.026 14.3 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 KH domain Pkinase PF00069.25 EDK39207.2 - 6e-72 242.2 0.0 3e-71 239.9 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39207.2 - 6.8e-36 123.9 0.0 1.6e-35 122.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 EDK39207.2 - 6.7e-33 112.9 0.2 1.5e-32 111.7 0.2 1.7 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 EDK39207.2 - 4.1e-05 23.0 0.0 0.0014 18.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDK39207.2 - 0.023 14.6 0.1 0.055 13.4 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family EMG1 PF03587.14 EDK39209.1 - 1.5e-78 262.9 0.0 1.7e-78 262.7 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 EDK39209.1 - 0.026 14.3 0.2 0.039 13.7 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein RP854 LCD1 PF09798.9 EDK39210.2 - 1.5e-182 608.4 12.5 1.7e-182 608.2 12.5 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein Fez1 PF06818.15 EDK39210.2 - 0.019 15.4 2.6 0.031 14.7 2.6 1.3 1 0 0 1 1 1 0 Fez1 Macoilin PF09726.9 EDK39210.2 - 0.039 12.5 2.9 0.061 11.9 2.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF4600 PF15372.6 EDK39210.2 - 0.1 13.0 2.6 0.26 11.7 2.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) TolA_bind_tri PF16331.5 EDK39210.2 - 0.13 12.3 2.7 0.2 11.8 0.8 2.2 1 1 1 2 2 2 0 TolA binding protein trimerisation Spc7 PF08317.11 EDK39210.2 - 0.21 10.5 7.4 0.34 9.8 7.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 EDK39210.2 - 0.3 11.3 6.8 8.4 6.7 1.7 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding RRP36 PF06102.12 EDK39210.2 - 1.4 8.9 3.8 2.7 7.9 3.8 1.4 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 PRKG1_interact PF15898.5 EDK39210.2 - 3 8.8 7.3 11 7.0 7.3 2.0 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Ribosomal_L37e PF01907.19 EDK39211.1 - 2.8e-28 97.9 10.8 2.8e-28 97.9 10.8 1.4 2 0 0 2 2 2 1 Ribosomal protein L37e zf-ribbon_3 PF13248.6 EDK39211.1 - 0.0088 15.4 2.0 0.015 14.7 2.0 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 EDK39211.1 - 0.01 15.8 2.6 0.015 15.3 2.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EDK39211.1 - 0.19 11.7 1.6 0.25 11.4 1.6 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1258 PF06869.12 EDK39211.1 - 0.25 10.8 3.7 0.23 10.9 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) GATA PF00320.27 EDK39211.1 - 0.3 10.7 6.9 0.25 11.0 1.6 2.3 1 1 1 2 2 2 0 GATA zinc finger zf-HYPF PF07503.12 EDK39211.1 - 3.6 7.4 7.4 32 4.4 4.5 2.8 2 1 1 3 3 3 0 HypF finger DUF3829 PF12889.7 EDK39213.2 - 0.0097 15.4 3.7 0.4 10.1 0.7 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3829) DUF948 PF06103.11 EDK39213.2 - 0.039 14.2 13.8 1.5 9.2 1.2 4.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF835 PF05763.12 EDK39214.2 - 0.023 14.4 0.5 0.05 13.3 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF835) PRK PF00485.18 EDK39214.2 - 0.053 13.3 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family PAP2 PF01569.21 EDK39216.2 - 1.2e-24 86.6 1.0 1.2e-24 86.6 1.0 1.8 2 1 1 3 3 3 1 PAP2 superfamily Tmemb_14 PF03647.13 EDK39216.2 - 3.4 8.5 6.6 0.5 11.1 1.1 2.2 2 1 0 2 2 2 0 Transmembrane proteins 14C SH3_9 PF14604.6 EDK39217.2 - 3.6e-07 29.9 0.1 1.5e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EDK39217.2 - 4.2e-05 23.1 0.2 0.0003 20.3 0.2 2.3 1 1 0 1 1 1 1 SH3 domain DUF4448 PF14610.6 EDK39217.2 - 0.01 15.6 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SH3_2 PF07653.17 EDK39217.2 - 0.014 15.1 0.4 0.043 13.5 0.0 2.0 3 0 0 3 3 3 0 Variant SH3 domain DUF5383 PF17355.2 EDK39217.2 - 0.13 12.6 0.1 0.32 11.4 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5383) RAP1 PF07218.11 EDK39217.2 - 1.4 7.1 3.8 1.6 6.9 3.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PH PF00169.29 EDK39218.2 - 2.5e-09 37.6 0.1 6.8e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 PH domain Vta1 PF04652.16 EDK39219.2 - 2.4e-33 115.1 0.1 4.3e-33 114.3 0.1 1.4 1 0 0 1 1 1 1 Vta1 like DUF3073 PF11273.8 EDK39219.2 - 4.7 8.0 7.0 16 6.3 7.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) Sdh5 PF03937.16 EDK39220.2 - 2.8e-28 97.7 0.9 4.2e-28 97.1 0.9 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase EF-hand_7 PF13499.6 EDK39221.2 - 3e-16 59.6 4.9 2.2e-09 37.6 0.1 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDK39221.2 - 6.7e-16 56.8 3.4 1.9e-05 24.2 0.1 5.3 6 0 0 6 6 6 4 EF-hand domain EF-hand_1 PF00036.32 EDK39221.2 - 2.6e-14 51.6 4.7 1.6e-05 24.1 0.1 5.3 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.6 EDK39221.2 - 3.1e-06 26.9 4.0 0.0015 18.4 1.1 4.4 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_9 PF14658.6 EDK39221.2 - 0.0076 16.6 1.5 0.44 10.9 0.2 3.3 2 1 1 3 3 3 1 EF-hand domain Mac-1 PF09028.10 EDK39221.2 - 0.032 13.3 0.1 0.04 13.0 0.1 1.1 1 0 0 1 1 1 0 Mac 1 EF-hand_4 PF12763.7 EDK39221.2 - 0.06 13.3 0.2 0.15 12.1 0.1 1.8 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SUIM_assoc PF16619.5 EDK39221.2 - 0.22 11.6 0.5 0.42 10.7 0.5 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 EF-hand_5 PF13202.6 EDK39221.2 - 0.44 10.1 8.8 5.2 6.7 0.1 4.5 5 0 0 5 5 5 0 EF hand Ank_2 PF12796.7 EDK39222.2 - 2.1e-09 37.8 0.0 0.0028 18.2 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDK39222.2 - 3.3e-07 30.5 0.8 0.083 13.4 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EDK39222.2 - 5.5e-07 29.7 0.1 0.00013 22.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) KilA-N PF04383.13 EDK39222.2 - 2e-05 24.4 0.0 5.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 KilA-N domain Ank_3 PF13606.6 EDK39222.2 - 2.3e-05 24.4 0.1 0.026 15.1 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EDK39222.2 - 0.00038 21.0 0.3 5.4 7.7 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) DUF727 PF05303.12 EDK39222.2 - 0.069 13.2 0.1 0.26 11.4 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF727) SF3A2 PF16835.5 EDK39223.1 - 2.2e-29 101.6 0.3 3.3e-29 101.1 0.3 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EDK39223.1 - 2e-06 28.0 1.1 4.7e-06 26.8 0.9 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK39223.1 - 0.035 14.4 0.2 0.14 12.5 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding OrsD PF12013.8 EDK39223.1 - 0.046 14.2 0.0 0.088 13.3 0.0 1.5 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D PAPS_reduct PF01507.19 EDK39224.1 - 9.7e-18 64.8 0.1 8.4e-16 58.5 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family HLH PF00010.26 EDK39225.2 - 2.7e-16 59.3 0.0 5.6e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tom22 PF04281.13 EDK39225.2 - 0.11 12.3 0.5 0.2 11.5 0.5 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 SIR2 PF02146.17 EDK39227.2 - 6.3e-63 211.9 0.0 9e-63 211.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EDK39227.2 - 8.9e-32 110.0 0.1 1.1e-14 54.5 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EDK39227.2 - 3.2e-05 23.7 0.0 0.004 16.9 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain CutC PF03932.14 EDK39227.2 - 0.13 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 CutC family CMAS PF02353.20 EDK39228.2 - 4.8e-63 213.0 0.6 5.8e-63 212.7 0.6 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EDK39228.2 - 1.7e-12 47.5 0.0 3e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK39228.2 - 9.9e-08 32.6 0.0 1.7e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK39228.2 - 2.2e-06 28.2 0.0 4.2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EDK39228.2 - 0.00022 21.4 0.1 0.00097 19.3 0.0 2.1 2 1 1 3 3 3 1 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 EDK39228.2 - 0.0067 17.2 0.0 0.014 16.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK39228.2 - 0.023 14.5 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 EDK39228.2 - 0.026 14.0 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 EDK39228.2 - 0.033 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain AI-2E_transport PF01594.16 EDK39228.2 - 0.035 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 AI-2E family transporter COX7C PF02935.16 EDK39228.2 - 0.067 13.5 7.4 0.048 13.9 5.1 2.0 2 0 0 2 2 1 0 Cytochrome c oxidase subunit VIIc Malate_synthase PF01274.22 EDK39229.1 - 4.4e-225 747.9 0.0 5e-225 747.7 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 EDK39229.1 - 0.078 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Glutaredoxin PF00462.24 EDK39230.2 - 2.6e-13 50.0 0.0 4.7e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin ANAPC9 PF12856.7 EDK39231.2 - 2.7e-28 98.5 0.0 9.5e-28 96.8 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 9 DUF4864 PF16156.5 EDK39231.2 - 0.054 14.2 0.2 0.13 13.0 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) LisH PF08513.11 EDK39231.2 - 0.15 12.1 0.4 0.33 11.0 0.4 1.6 1 0 0 1 1 1 0 LisH Candida_ALS PF05792.13 EDK39232.2 - 3.2e-96 315.5 556.6 7.9e-08 32.7 24.2 20.7 22 0 0 22 22 22 16 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.8 EDK39232.2 - 6.4e-89 297.5 11.3 1.1e-88 296.8 11.3 1.4 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding Pyr_redox_2 PF07992.14 EDK39233.2 - 8.1e-57 192.7 1.3 1.3e-56 192.0 1.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDK39233.2 - 4e-33 114.0 0.4 1.1e-32 112.5 0.2 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDK39233.2 - 1.8e-17 63.6 4.3 1.2e-14 54.6 0.4 2.9 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK39233.2 - 7.1e-10 38.6 1.4 2.5e-07 30.3 0.4 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDK39233.2 - 2.5e-07 30.4 0.1 3.6e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDK39233.2 - 4.8e-06 25.5 2.5 0.014 14.1 0.1 3.1 3 0 0 3 3 3 2 HI0933-like protein K_oxygenase PF13434.6 EDK39233.2 - 1.2e-05 24.6 0.0 2.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EDK39233.2 - 2.7e-05 23.4 3.4 0.0011 18.1 1.2 2.8 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.22 EDK39233.2 - 0.00054 19.2 0.5 0.00054 19.2 0.5 3.5 3 1 1 4 4 4 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDK39233.2 - 0.00089 19.4 0.6 0.00089 19.4 0.6 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDK39233.2 - 0.0038 16.9 0.9 0.0038 16.9 0.9 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EDK39233.2 - 0.006 15.9 0.6 0.22 10.8 0.1 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EDK39233.2 - 0.007 15.7 1.6 1 8.6 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain 2-Hacid_dh_C PF02826.19 EDK39233.2 - 0.018 14.4 0.7 2.3 7.6 0.1 3.1 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EDK39233.2 - 0.063 13.2 2.6 0.66 9.8 0.1 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 EDK39233.2 - 0.083 12.1 0.5 0.18 11.0 0.1 1.8 2 0 0 2 2 2 0 Thi4 family LSM PF01423.22 EDK39234.1 - 1.5e-12 47.0 0.6 1.8e-12 46.7 0.6 1.1 1 0 0 1 1 1 1 LSM domain Zn_clus PF00172.18 EDK39235.2 - 3.6e-09 36.6 6.2 1e-08 35.1 6.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YvfG PF09628.10 EDK39235.2 - 0.0066 16.8 0.2 0.024 15.0 0.2 2.0 1 0 0 1 1 1 1 YvfG protein SlyX PF04102.12 EDK39235.2 - 0.79 10.4 4.1 0.33 11.6 0.2 2.2 2 0 0 2 2 2 0 SlyX Dickkopf_N PF04706.12 EDK39235.2 - 7.6 7.1 12.2 1.2 9.7 6.0 2.6 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region ABC1 PF03109.16 EDK39236.2 - 4.8e-34 117.1 0.0 9.3e-34 116.1 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EDK39236.2 - 0.0056 16.3 0.0 0.048 13.2 0.0 2.3 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 EDK39236.2 - 0.038 13.4 0.1 2.1 7.7 0.2 2.2 2 0 0 2 2 2 0 Protein kinase domain DDE_Tnp_4 PF13359.6 EDK39236.2 - 0.049 13.3 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease FGase PF05013.12 EDK39236.2 - 0.086 13.0 0.1 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 N-formylglutamate amidohydrolase Aa_trans PF01490.18 EDK39237.2 - 7.9e-76 255.4 28.0 9.3e-76 255.1 28.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein OppC_N PF12911.7 EDK39237.2 - 0.094 12.7 1.2 2.2 8.3 0.2 3.0 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C TIMELESS PF04821.14 EDK39238.2 - 8.8e-84 281.0 8.4 1e-81 274.3 0.8 2.3 2 0 0 2 2 2 2 Timeless protein DUF433 PF04255.14 EDK39238.2 - 0.2 11.6 0.0 0.52 10.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Fungal_trans PF04082.18 EDK39239.2 - 4.8e-09 35.6 0.1 1.2e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39239.2 - 5.2e-05 23.3 12.5 0.00013 22.1 12.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK39240.2 - 5.3e-12 45.3 0.1 9.9e-12 44.4 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39240.2 - 6e-08 32.7 9.2 1.2e-07 31.8 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cyclin_N PF00134.23 EDK39241.2 - 2.3e-19 69.4 0.0 3.5e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDK39241.2 - 3.2e-07 30.8 1.3 3.5e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 Cyclin Cmc1 PF08583.10 EDK39243.2 - 0.024 14.7 0.2 0.029 14.4 0.2 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like TRP PF06011.12 EDK39244.2 - 1e-69 235.3 14.4 8.9e-55 186.1 5.6 2.2 1 1 1 2 2 2 2 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDK39244.2 - 0.001 19.5 1.1 0.16 12.3 0.3 2.5 2 0 0 2 2 2 2 ML-like domain Ni_hydr_CYTB PF01292.20 EDK39244.2 - 0.66 9.5 14.8 1.2 8.7 5.1 3.4 2 2 0 3 3 3 0 Prokaryotic cytochrome b561 SET PF00856.28 EDK39245.2 - 1.7e-18 67.6 0.0 3.3e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 SET domain PQQ_3 PF13570.6 EDK39246.2 - 1.8e-05 25.1 2.7 0.011 16.3 0.1 4.0 4 0 0 4 4 4 1 PQQ-like domain WD40_like PF17005.5 EDK39246.2 - 0.00047 19.6 0.0 1 8.6 0.1 2.3 2 0 0 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 EDK39246.2 - 0.0011 18.6 0.1 0.0036 16.9 0.1 1.8 2 0 0 2 2 2 1 PQQ-like domain WD40 PF00400.32 EDK39246.2 - 0.046 14.6 0.5 1.7 9.6 0.0 3.5 4 0 0 4 4 4 0 WD domain, G-beta repeat Reg_prop PF07494.11 EDK39246.2 - 0.14 12.5 0.1 0.47 10.9 0.1 1.9 1 0 0 1 1 1 0 Two component regulator propeller DUF2462 PF09495.10 EDK39248.2 - 0.4 11.5 0.1 0.4 11.5 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2462) Tombus_movement PF05318.12 EDK39248.2 - 3.8 8.4 6.0 2.9 8.8 0.4 2.7 2 0 0 2 2 2 0 Tombusvirus movement protein Pkinase PF00069.25 EDK39249.2 - 5.7e-40 137.4 0.0 1.1e-30 106.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39249.2 - 8.8e-18 64.5 0.0 2e-12 47.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDK39249.2 - 0.00044 19.7 0.4 0.41 9.9 0.2 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EDK39249.2 - 0.092 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Med14 PF08638.11 EDK39250.2 - 2.9e-14 52.9 0.0 7.5e-13 48.3 0.0 2.7 2 0 0 2 2 2 1 Mediator complex subunit MED14 Mt_ATP_synt PF15704.5 EDK39251.2 - 0.22 11.4 0.0 0.29 11.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit Zn_clus PF00172.18 EDK39252.2 - 1.6e-05 24.9 21.2 0.00018 21.5 10.6 2.5 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5447 PF17525.2 EDK39252.2 - 8.3 7.0 8.6 1.9 9.0 0.7 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5447) Aldose_epim PF01263.20 EDK39255.2 - 5e-41 141.0 0.2 5.8e-41 140.8 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase PAP2_3 PF14378.6 EDK39256.2 - 3.9e-24 85.4 14.1 3.9e-24 85.4 14.1 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EDK39256.2 - 6.9e-11 42.1 6.6 6.9e-11 42.1 6.6 2.4 2 0 0 2 2 2 1 PAP2 superfamily Ribosomal_S6 PF01250.17 EDK39257.2 - 5.6e-27 93.8 0.0 6.7e-27 93.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 APS_kinase PF01583.20 EDK39258.1 - 4.6e-73 244.3 0.0 5.5e-73 244.1 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EDK39258.1 - 4.8e-06 26.8 0.0 1.3e-05 25.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EDK39258.1 - 0.00016 21.2 0.0 0.00021 20.8 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 EDK39258.1 - 0.0014 19.2 0.1 0.0027 18.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EDK39258.1 - 0.0036 16.6 0.0 0.005 16.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 EDK39258.1 - 0.0099 15.6 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain G-alpha PF00503.20 EDK39258.1 - 0.014 14.6 0.1 0.063 12.4 0.0 2.0 2 1 0 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 EDK39258.1 - 0.02 15.3 0.1 0.034 14.5 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 EDK39258.1 - 0.033 14.3 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CPT PF07931.12 EDK39258.1 - 0.054 13.3 0.1 0.9 9.4 0.1 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Snf7 PF03357.21 EDK39259.2 - 1.7e-28 99.3 22.2 1.7e-28 99.3 22.2 2.0 1 1 1 2 2 2 2 Snf7 Ist1 PF03398.14 EDK39259.2 - 0.00034 20.6 5.9 0.00056 19.9 5.9 1.5 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway RNA_pol_Rpb2_45 PF10385.9 EDK39259.2 - 0.46 10.8 0.1 0.46 10.8 0.1 2.3 3 0 0 3 3 3 0 RNA polymerase beta subunit external 1 domain DUF3349 PF11829.8 EDK39259.2 - 0.65 10.8 5.3 0.19 12.5 0.6 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3349) D5_N PF08706.11 EDK39259.2 - 1.7 8.9 4.4 2.4 8.4 4.1 1.8 1 1 0 1 1 1 0 D5 N terminal like Seryl_tRNA_N PF02403.22 EDK39259.2 - 7.7 6.8 17.9 0.33 11.2 9.4 2.7 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DAO PF01266.24 EDK39261.2 - 8.9e-21 74.9 0.0 1e-20 74.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Crl PF07417.12 EDK39261.2 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl Cu-oxidase_3 PF07732.15 EDK39262.2 - 2.1e-45 153.5 2.4 3.7e-43 146.3 0.5 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDK39262.2 - 3.4e-45 153.1 12.3 1.5e-41 141.3 2.0 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EDK39262.2 - 2.1e-32 112.5 1.8 7.5e-32 110.7 1.1 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EDK39262.2 - 0.01 15.9 0.0 48 4.1 0.0 3.6 3 0 0 3 3 3 0 Cupredoxin-like domain Cnd1 PF12717.7 EDK39263.2 - 0.072 13.1 0.1 0.072 13.1 0.1 5.3 5 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 DUF5082 PF16888.5 EDK39264.2 - 0.016 15.5 2.6 0.016 15.5 2.6 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 EDK39264.2 - 5.6 5.7 29.0 1.1 8.0 16.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Gp58 PF07902.11 EDK39264.2 - 6.6 4.9 12.3 1.8 6.8 7.3 1.9 1 1 1 2 2 2 0 gp58-like protein ADIP PF11559.8 EDK39264.2 - 8.1 6.5 26.7 2.9 8.0 15.3 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1192 PF06698.11 EDK39264.2 - 9.8 6.3 19.3 0.71 10.0 0.5 5.3 5 1 1 6 6 6 0 Protein of unknown function (DUF1192) Myb_DNA-binding PF00249.31 EDK39265.2 - 1.2e-21 76.6 11.9 2.9e-11 43.4 0.6 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK39265.2 - 5.4e-16 58.6 11.0 2.7e-13 50.0 1.5 3.2 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDK39265.2 - 9.3e-05 22.7 12.5 0.00011 22.5 2.9 3.6 2 1 1 3 3 3 2 Myb/SANT-like DNA-binding domain Sec5 PF15469.6 EDK39266.2 - 5.4e-40 137.2 12.1 5.4e-40 137.2 12.1 3.7 4 1 0 4 4 4 1 Exocyst complex component Sec5 Vps51 PF08700.11 EDK39266.2 - 5.3e-06 26.4 2.4 5.3e-06 26.4 2.4 2.9 2 0 0 2 2 2 1 Vps51/Vps67 FTR1 PF03239.14 EDK39267.2 - 1.3e-93 313.6 4.5 1.6e-93 313.3 4.5 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Tmemb_14 PF03647.13 EDK39267.2 - 0.026 15.3 4.9 1.4 9.7 0.1 2.6 2 0 0 2 2 2 0 Transmembrane proteins 14C DSRB PF10781.9 EDK39267.2 - 0.091 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Dextransucrase DSRB MgtE PF01769.16 EDK39267.2 - 1.9 8.9 13.0 1.9 8.9 1.5 2.5 2 0 0 2 2 2 0 Divalent cation transporter MFS_1 PF07690.16 EDK39268.2 - 3e-36 125.1 35.6 3e-36 125.1 35.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sybindin PF04099.12 EDK39268.2 - 0.094 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Sybindin-like family DDA1 PF10172.9 EDK39269.2 - 0.023 15.0 0.8 0.1 12.9 0.2 2.1 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase TruB_N PF01509.18 EDK39270.2 - 5.3e-45 153.4 0.1 6.3e-44 149.9 0.1 2.2 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDK39270.2 - 1.8e-06 28.0 0.0 4.5e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Erf4 PF10256.9 EDK39271.2 - 1.6e-29 102.4 0.0 2.1e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DivIVA PF05103.13 EDK39271.2 - 0.037 14.1 0.0 0.058 13.5 0.0 1.2 1 0 0 1 1 1 0 DivIVA protein DUF1331 PF07048.11 EDK39271.2 - 0.13 11.9 0.1 0.25 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) DUF3981 PF13139.6 EDK39272.2 - 0.3 11.5 2.6 0.42 11.0 2.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) DUF3087 PF11286.8 EDK39272.2 - 1.6 8.2 5.4 0.59 9.6 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3087) DUF2069 PF09842.9 EDK39273.2 - 0.0013 18.9 0.1 0.0032 17.6 0.0 1.7 1 1 1 2 2 2 1 Predicted membrane protein (DUF2069) PPR_2 PF13041.6 EDK39274.2 - 1.2e-16 60.7 15.9 0.0027 17.9 0.0 7.4 5 2 2 8 8 8 5 PPR repeat family PPR PF01535.20 EDK39274.2 - 6.4e-15 54.3 12.6 0.23 11.8 0.0 8.7 9 0 0 9 9 9 5 PPR repeat PPR_3 PF13812.6 EDK39274.2 - 1.1e-11 44.6 0.8 0.1 12.7 0.2 5.1 4 1 0 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 EDK39274.2 - 0.00019 21.1 9.5 0.0086 15.8 0.0 5.1 6 0 0 6 6 6 2 PPR repeat RPM2 PF08579.11 EDK39274.2 - 0.0028 18.1 3.6 0.74 10.2 0.1 4.3 4 1 1 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) Cyto_heme_lyase PF01265.17 EDK39275.2 - 4.7e-95 318.5 3.8 3.8e-94 315.5 3.8 2.2 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase OTU PF02338.19 EDK39276.2 - 1.3e-20 74.1 2.1 7.5e-20 71.7 0.0 2.6 3 0 0 3 3 3 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EDK39276.2 - 1e-05 25.1 0.6 5.1e-05 22.8 0.2 2.2 1 1 0 1 1 1 1 Peptidase C65 Otubain Cyclin_N PF00134.23 EDK39277.2 - 1.7e-36 124.7 1.3 3.1e-36 123.9 1.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.6 EDK39278.2 - 2.3e-40 138.9 0.0 5.2e-40 137.8 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EDK39278.2 - 1.9e-06 27.6 0.0 0.00017 21.2 0.0 2.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 EDK39278.2 - 0.025 15.0 0.0 0.075 13.5 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 EDK39278.2 - 0.051 13.3 0.0 17 5.2 0.0 2.7 3 0 0 3 3 3 0 Cupin domain Trypan_PARP PF05887.11 EDK39278.2 - 0.16 12.0 8.5 0.28 11.2 8.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ARD PF03079.14 EDK39278.2 - 0.65 10.2 6.4 0.86 9.8 0.0 3.0 3 0 0 3 3 3 0 ARD/ARD' family Nop14 PF04147.12 EDK39278.2 - 3.7 5.7 13.5 6.5 4.8 13.5 1.3 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 EDK39278.2 - 6.2 7.1 14.5 1.8 8.8 9.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 EDK39278.2 - 8.8 5.5 9.7 14 4.8 9.7 1.2 1 0 0 1 1 1 0 NOA36 protein ETF_QO PF05187.13 EDK39280.2 - 3.8e-45 152.3 0.7 6.6e-45 151.5 0.7 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 EDK39280.2 - 2.7e-10 39.9 0.3 0.00052 19.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EDK39280.2 - 4.3e-10 39.7 0.0 4.8e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDK39280.2 - 4.3e-06 26.2 0.1 7.8e-05 22.0 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK39280.2 - 6.2e-06 26.7 0.1 0.014 15.9 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK39280.2 - 9.1e-06 25.8 0.0 2.1e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDK39280.2 - 1.5e-05 23.9 0.0 4.7e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EDK39280.2 - 1.9e-05 24.1 0.2 0.0048 16.2 0.1 2.2 1 1 1 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EDK39280.2 - 6.9e-05 22.3 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EDK39280.2 - 0.00032 19.7 0.1 0.084 11.7 0.1 2.5 2 1 1 3 3 3 2 Tryptophan halogenase Pyr_redox_3 PF13738.6 EDK39280.2 - 0.0006 19.2 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDK39280.2 - 0.0008 18.9 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDK39280.2 - 0.0026 17.8 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.7 EDK39280.2 - 0.013 16.1 0.7 0.033 14.8 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 EDK39280.2 - 0.11 11.5 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein RhoGEF PF00621.20 EDK39281.2 - 3.6e-32 112.1 0.0 6.8e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.11 EDK39281.2 - 5.1e-32 110.0 0.0 1.1e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin PH_10 PF15411.6 EDK39281.2 - 2.5e-25 89.1 0.1 5.4e-25 88.0 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 EDK39281.2 - 2.3e-06 27.5 0.0 1e-05 25.3 0.0 2.2 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 EDK39281.2 - 0.098 13.2 0.1 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 PH domain Pterin_bind PF00809.22 EDK39282.2 - 1.8e-66 224.3 0.3 9.5e-46 156.4 0.1 2.3 1 1 1 2 2 2 2 Pterin binding enzyme FolB PF02152.18 EDK39282.2 - 1.2e-38 132.1 2.8 1.5e-20 73.8 0.5 3.2 3 0 0 3 3 3 2 Dihydroneopterin aldolase HPPK PF01288.20 EDK39282.2 - 6.8e-34 116.7 0.0 2.2e-33 115.1 0.0 1.9 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) HD_2 PF12917.7 EDK39282.2 - 0.011 15.5 0.1 0.026 14.3 0.1 1.5 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Thiamine_BP PF01910.17 EDK39282.2 - 0.17 11.8 6.7 0.83 9.6 0.1 4.0 4 0 0 4 4 4 0 Thiamine-binding protein RTC4 PF14474.6 EDK39283.2 - 5.7e-32 110.4 0.1 5.7e-32 110.4 0.1 1.9 2 0 0 2 2 2 1 RTC4-like domain RRM_1 PF00076.22 EDK39284.2 - 7.1e-05 22.5 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EDK39284.2 - 0.00017 22.4 0.1 0.00047 20.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Esterase_phd PF10503.9 EDK39284.2 - 0.021 14.3 1.1 0.04 13.4 1.1 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Spo7_2_N PF15407.6 EDK39284.2 - 0.054 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_7 PF16367.5 EDK39284.2 - 0.077 13.1 0.0 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif PT PF04886.12 EDK39284.2 - 0.68 9.5 15.1 1.8 8.2 6.1 3.1 2 0 0 2 2 2 0 PT repeat MCLC PF05934.11 EDK39284.2 - 0.7 8.6 1.5 1 8.0 1.5 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) MRP-L46 PF11788.8 EDK39285.2 - 1.3e-42 145.3 1.5 2.1e-42 144.6 1.5 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 COPIIcoated_ERV PF07970.12 EDK39286.2 - 8.7e-74 248.1 0.0 1.1e-73 247.8 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDK39286.2 - 5.5e-28 97.2 0.4 3e-27 94.8 0.1 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ANAPC4_WD40 PF12894.7 EDK39287.2 - 2.1e-09 37.6 0.4 0.013 15.7 0.1 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK39287.2 - 2.4e-09 37.7 8.4 0.0027 18.5 0.1 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EDK39287.2 - 0.00018 20.1 1.0 0.013 14.0 0.2 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain SdiA-regulated PF06977.11 EDK39287.2 - 0.0021 17.3 0.0 0.0054 16.0 0.0 1.7 2 0 0 2 2 2 1 SdiA-regulated BBS2_Mid PF14783.6 EDK39287.2 - 0.0051 16.8 0.1 0.022 14.8 0.0 2.1 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EDK39287.2 - 0.011 15.7 0.2 2.1 8.2 0.0 2.5 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Peptidase_S9_N PF02897.15 EDK39287.2 - 0.011 14.6 0.1 0.039 12.7 0.0 2.0 3 0 0 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain zf-CCHC PF00098.23 EDK39288.2 - 2.4e-47 156.9 60.4 1.7e-07 31.0 3.1 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EDK39288.2 - 2.7e-14 52.6 40.3 0.014 15.2 0.3 7.0 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EDK39288.2 - 0.00016 21.5 49.9 0.31 11.0 1.0 7.0 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.6 EDK39288.2 - 0.00032 20.3 43.3 0.079 12.7 1.2 7.3 5 2 3 8 8 8 5 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EDK39288.2 - 0.042 13.7 2.4 0.042 13.7 2.4 7.0 5 1 2 7 7 7 0 Zinc knuckle Pro_isomerase PF00160.21 EDK39289.2 - 6.5e-10 39.5 0.1 1.4e-09 38.4 0.0 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EDK39289.2 - 1.3e-08 34.5 0.1 6.2e-08 32.4 0.0 2.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK39289.2 - 0.025 14.2 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.21 EDK39290.2 - 4e-06 26.8 16.1 4e-06 26.8 16.1 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EDK39290.2 - 0.024 14.7 13.4 0.024 14.7 13.4 2.7 3 1 1 4 4 4 0 Basic region leucine zipper LMSTEN PF07988.12 EDK39290.2 - 0.077 12.5 2.8 0.22 11.0 2.8 1.8 1 0 0 1 1 1 0 LMSTEN motif Macoilin PF09726.9 EDK39290.2 - 2.2 6.7 17.5 2.9 6.4 17.5 1.1 1 0 0 1 1 1 0 Macoilin family EVI2A PF05399.11 EDK39290.2 - 8.8 5.9 11.2 2.4 7.7 7.3 2.0 1 1 1 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) TPR_1 PF00515.28 EDK39291.2 - 3.3e-50 165.9 33.4 3.1e-08 33.1 0.7 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EDK39291.2 - 2.5e-40 133.3 33.0 3.5e-08 33.0 0.4 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 EDK39291.2 - 6.4e-32 109.3 17.4 2.5e-17 62.6 9.8 3.0 2 0 0 2 2 2 2 STI1 domain TPR_16 PF13432.6 EDK39291.2 - 4.8e-23 81.5 11.3 4.3e-06 27.3 0.3 6.0 6 1 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK39291.2 - 8e-23 78.7 30.6 1.1e-06 28.4 0.4 9.0 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDK39291.2 - 1.8e-22 78.7 26.7 8.7e-05 22.1 0.3 8.5 7 2 1 8 8 8 6 TPR repeat TPR_14 PF13428.6 EDK39291.2 - 1.2e-18 66.2 10.1 0.018 15.8 0.0 8.5 5 3 4 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EDK39291.2 - 3.7e-18 65.6 22.3 6.4e-06 26.4 1.1 7.0 3 3 4 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 EDK39291.2 - 4.5e-14 51.3 14.6 0.022 14.8 0.0 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDK39291.2 - 1.3e-13 51.2 21.1 0.00015 22.2 1.9 6.6 3 3 4 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDK39291.2 - 1.5e-13 50.1 17.6 0.39 11.2 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 EDK39291.2 - 1.9e-11 43.4 14.4 0.0087 15.9 0.0 7.4 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDK39291.2 - 5.2e-10 39.3 4.1 0.00057 20.0 0.0 5.3 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDK39291.2 - 1e-08 35.3 24.9 1.2 9.9 0.0 8.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK39291.2 - 1.8e-08 34.1 4.3 9.5e-07 28.5 0.6 2.2 2 0 0 2 2 2 2 MalT-like TPR region Fis1_TPR_C PF14853.6 EDK39291.2 - 1.8e-06 27.9 7.9 0.00022 21.2 0.2 5.3 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EDK39291.2 - 6.9e-05 23.0 17.3 0.089 13.0 2.4 5.2 2 2 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EDK39291.2 - 0.019 14.7 23.7 0.24 11.1 0.1 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain PPR_2 PF13041.6 EDK39291.2 - 0.024 14.8 0.9 11 6.4 0.0 4.1 5 0 0 5 5 3 0 PPR repeat family Inhibitor_I9 PF05922.16 EDK39291.2 - 0.037 14.7 0.3 0.23 12.2 0.0 2.5 2 0 0 2 2 1 0 Peptidase inhibitor I9 DUF5486 PF17588.2 EDK39291.2 - 0.054 13.4 0.2 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5486) DUF3808 PF10300.9 EDK39291.2 - 0.087 11.5 6.3 0.05 12.3 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) SPO22 PF08631.10 EDK39291.2 - 0.63 9.5 11.0 19 4.6 0.3 4.7 5 0 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like GerD PF17898.1 EDK39291.2 - 1.4 8.9 7.4 2.3 8.2 2.1 3.4 3 1 0 3 3 3 0 Spore germination GerD central core domain TPR_20 PF14561.6 EDK39291.2 - 2.4 8.6 10.8 15 6.0 0.1 4.6 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 EDK39291.2 - 3.7 7.6 26.8 0.62 10.1 0.7 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Fungal_trans PF04082.18 EDK39292.2 - 1.2e-15 57.3 3.0 2.8e-15 56.1 3.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39292.2 - 3.8e-07 30.1 15.6 8e-07 29.1 15.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EDK39293.2 - 1.9e-07 31.1 16.2 3.9e-07 30.1 16.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK39293.2 - 4.4e-07 29.2 3.0 7e-07 28.5 0.4 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain NARP1 PF12569.8 EDK39294.2 - 1.5e-130 436.5 28.9 3.5e-98 329.8 2.9 4.5 3 2 0 3 3 3 3 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EDK39294.2 - 4.8e-12 45.0 13.4 0.063 13.4 0.1 8.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK39294.2 - 5.1e-09 36.6 1.7 0.007 17.0 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDK39294.2 - 5.9e-09 36.3 3.6 0.039 14.5 0.0 5.4 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDK39294.2 - 1.5e-08 34.8 3.8 0.1 13.4 0.0 7.7 7 2 3 10 10 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK39294.2 - 7e-08 32.6 19.1 5.6e-05 23.3 0.6 5.7 6 1 0 7 7 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDK39294.2 - 2.3e-06 27.6 3.6 0.82 10.2 0.0 5.6 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK39294.2 - 0.00029 20.5 13.2 0.66 9.9 0.0 7.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDK39294.2 - 0.00036 20.5 19.0 0.023 14.9 0.0 7.6 10 0 0 10 10 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDK39294.2 - 0.0018 18.4 0.1 7.6 6.8 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat AP3D1 PF06375.11 EDK39294.2 - 0.0023 18.2 1.5 0.0052 17.0 1.5 1.5 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 TPR_12 PF13424.6 EDK39294.2 - 0.006 16.8 9.4 1.2 9.4 0.0 5.5 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDK39294.2 - 0.0096 15.6 4.3 0.29 10.8 0.0 3.9 4 0 0 4 4 4 1 TPR repeat DUF627 PF04781.12 EDK39294.2 - 0.018 15.1 0.8 0.22 11.6 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF627) Rapsyn_N PF10579.9 EDK39294.2 - 0.02 15.0 0.1 0.099 12.8 0.1 2.2 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region TPR_7 PF13176.6 EDK39294.2 - 0.023 14.7 3.2 17 5.7 0.0 6.2 8 1 0 8 8 5 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EDK39294.2 - 0.049 13.7 13.0 0.066 13.2 0.3 4.6 4 1 0 5 5 5 0 Putative TPR-like repeat TPR_10 PF13374.6 EDK39294.2 - 0.11 12.4 1.9 65 3.6 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat Tower PF09121.10 EDK39294.2 - 4.8 7.5 7.9 1.4 9.2 2.7 2.6 2 0 0 2 2 2 0 Tower HR1 PF02185.16 EDK39294.2 - 8.4 6.6 13.2 1.9 8.6 5.2 2.8 2 0 0 2 2 2 0 Hr1 repeat Got1 PF04178.12 EDK39295.2 - 2.5e-33 114.9 18.3 3.6e-33 114.4 18.3 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 EDK39295.2 - 0.011 14.1 11.6 0.013 13.8 11.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) S_4TM PF18159.1 EDK39295.2 - 1.8 7.8 5.2 3.2 7.0 5.2 1.4 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Blt1 PF12754.7 EDK39296.2 - 0.0064 16.8 0.1 0.012 16.0 0.1 1.5 1 0 0 1 1 1 1 Blt1 N-terminal domain Get5_bdg PF16843.5 EDK39296.2 - 0.059 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein SpoVAD PF07451.11 EDK39296.2 - 0.11 11.2 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) NCE101 PF11654.8 EDK39297.1 - 1e-23 82.8 0.1 1.2e-23 82.6 0.1 1.0 1 0 0 1 1 1 1 Non-classical export protein 1 RabGAP-TBC PF00566.18 EDK39298.2 - 8.2e-40 136.8 0.0 1.6e-39 135.8 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PalH PF08733.10 EDK39299.2 - 7.7e-90 301.2 9.6 9.7e-90 300.9 9.6 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF418 PF04235.12 EDK39299.2 - 0.12 12.2 0.2 0.12 12.2 0.2 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF418) UcrQ PF02939.16 EDK39299.2 - 0.18 11.7 1.2 0.52 10.3 0.1 2.2 2 0 0 2 2 2 0 UcrQ family Inv-AAD PF18785.1 EDK39300.2 - 6.6e-37 126.3 0.3 1.2e-36 125.4 0.3 1.4 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 EDK39300.2 - 5.7e-32 111.0 0.1 9e-32 110.4 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 EDK39300.2 - 4.8e-20 71.3 0.4 8.9e-20 70.5 0.4 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDK39300.2 - 2e-06 27.6 0.0 3.6e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase SNAD3 PF18749.1 EDK39300.2 - 0.029 13.5 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 3 MSA-2c PF12238.8 EDK39300.2 - 6.3 6.7 5.5 95 2.9 0.0 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c DUF3449 PF11931.8 EDK39301.2 - 7.1e-60 201.9 0.0 7.1e-60 201.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EDK39301.2 - 5.4e-17 62.1 1.8 2.1e-16 60.2 1.8 2.1 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 PRP9_N PF16958.5 EDK39301.2 - 8.4e-15 55.1 15.8 3.5e-14 53.1 10.5 3.2 2 1 0 2 2 2 1 Pre-mRNA-splicing factor PRP9 N-terminus zf-met PF12874.7 EDK39301.2 - 3.2e-12 46.4 8.4 6.1e-06 26.4 3.0 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK39301.2 - 1e-09 38.4 7.1 5.6e-09 36.1 2.9 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EDK39301.2 - 3.2e-05 24.2 2.7 0.013 15.8 0.2 3.6 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) DUF2397 PF09660.10 EDK39301.2 - 0.0078 15.2 0.2 0.019 13.9 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2397) zf-U1 PF06220.12 EDK39301.2 - 0.0083 15.9 3.3 0.0083 15.9 3.3 2.4 2 0 0 2 2 2 1 U1 zinc finger Zn_ribbon_2 PF12674.7 EDK39301.2 - 0.026 15.2 3.0 0.12 13.0 1.0 2.5 2 0 0 2 2 2 0 Putative zinc ribbon domain zf-3CxxC PF13695.6 EDK39301.2 - 0.1 13.0 1.6 0.48 10.9 0.2 2.4 2 0 0 2 2 2 0 Zinc-binding domain HD_assoc PF13286.6 EDK39301.2 - 0.32 11.5 1.7 0.75 10.4 0.1 2.4 3 0 0 3 3 2 0 Phosphohydrolase-associated domain zf-C2H2 PF00096.26 EDK39301.2 - 0.44 11.1 5.8 4.5 7.9 2.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK39301.2 - 0.56 11.2 2.8 15 6.8 0.7 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger YscO PF07321.12 EDK39301.2 - 1 9.3 7.5 0.12 12.3 2.6 2.0 2 0 0 2 2 2 0 Type III secretion protein YscO Exo_endo_phos PF03372.23 EDK39302.2 - 0.09 12.3 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family AA_permease PF00324.21 EDK39303.2 - 1.4e-136 455.9 43.7 1.8e-136 455.6 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK39303.2 - 8.5e-41 140.2 47.4 1.2e-40 139.7 47.4 1.0 1 0 0 1 1 1 1 Amino acid permease PAP_central PF04928.17 EDK39304.2 - 4.2e-112 373.1 0.0 5.7e-112 372.7 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EDK39304.2 - 1.6e-55 187.4 0.0 2.4e-55 186.8 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EDK39304.2 - 2.1e-13 50.4 0.0 6.6e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDK39304.2 - 0.058 13.5 0.1 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Nrap_D2 PF17403.2 EDK39304.2 - 0.069 12.9 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Oxysterol_BP PF01237.18 EDK39305.2 - 4.1e-86 289.2 0.6 7.5e-77 258.7 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein PI3_PI4_kinase PF00454.27 EDK39306.2 - 2.9e-35 122.3 0.2 2e-34 119.5 0.2 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EDK39306.2 - 8.2e-19 67.3 1.4 2.3e-18 65.9 1.4 1.9 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 EDK39306.2 - 2.4e-05 23.8 3.4 2.4e-05 23.8 3.4 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EDK39306.2 - 0.055 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PET122 PF05476.11 EDK39307.2 - 0.0024 17.2 0.1 0.0067 15.8 0.1 1.7 1 0 0 1 1 1 1 PET122 Sec10 PF07393.11 EDK39308.2 - 1.3e-73 248.6 18.5 1.6e-73 248.3 18.5 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.33 EDK39308.2 - 6e-07 29.2 0.0 2.7e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EDK39308.2 - 0.0077 16.1 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like Utp13 PF08625.11 EDK39309.2 - 0.00029 20.7 1.1 0.17 11.8 0.2 3.0 1 1 1 2 2 2 2 Utp13 specific WD40 associated domain DUF410 PF04190.13 EDK39309.2 - 0.032 14.0 0.2 0.097 12.5 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF410) PPR PF01535.20 EDK39309.2 - 0.15 12.4 0.2 9.9 6.7 0.0 3.8 5 0 0 5 5 5 0 PPR repeat Ribosomal_L31 PF01197.18 EDK39310.2 - 0.027 14.7 0.0 0.064 13.5 0.0 1.8 1 1 0 1 1 1 0 Ribosomal protein L31 Cpn60_TCP1 PF00118.24 EDK39311.2 - 7.3e-160 532.8 5.3 8.3e-160 532.6 5.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PNTB_4TM PF12769.7 EDK39311.2 - 0.058 13.9 0.1 0.16 12.4 0.1 1.7 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Cyclin_N PF00134.23 EDK39312.2 - 1.6e-40 137.7 0.7 5.8e-39 132.7 0.2 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDK39312.2 - 3.1e-10 40.2 0.0 9.2e-10 38.6 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Myosin_head PF00063.21 EDK39313.2 - 3.6e-257 855.0 9.1 3.6e-257 855.0 9.1 2.7 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 EDK39313.2 - 0.00036 20.3 1.3 0.00056 19.7 0.3 1.9 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain ATG16 PF08614.11 EDK39313.2 - 0.036 14.3 219.4 0.0091 16.2 20.0 12.0 3 2 6 11 11 11 0 Autophagy protein 16 (ATG16) AAA_22 PF13401.6 EDK39313.2 - 0.072 13.4 0.0 0.072 13.4 0.0 4.5 5 1 1 6 6 6 0 AAA domain AAA_16 PF13191.6 EDK39313.2 - 0.5 10.7 0.0 0.5 10.7 0.0 4.0 3 0 0 3 3 3 0 AAA ATPase domain Peptidase_M16_C PF05193.21 EDK39314.1 - 3.8e-38 131.3 0.0 1.1e-37 129.8 0.0 1.8 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDK39314.1 - 4.9e-33 114.2 0.0 2.5e-32 111.9 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DMAP_binding PF06464.11 EDK39314.1 - 0.03 15.1 0.7 0.056 14.3 0.7 1.4 1 0 0 1 1 1 0 DMAP1-binding Domain SMRP1 PF15181.6 EDK39314.1 - 0.055 13.1 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 CEP209_CC5 PF16574.5 EDK39314.1 - 0.15 12.2 1.5 0.28 11.3 1.5 1.3 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 Methyltransf_12 PF08242.12 EDK39315.2 - 0.00066 20.4 0.4 0.0083 16.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK39315.2 - 0.0049 17.5 0.0 0.01 16.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK39315.2 - 0.0092 16.7 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain BSP_II PF05432.11 EDK39315.2 - 0.011 15.4 9.1 0.018 14.8 9.1 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Methyltransf_4 PF02390.17 EDK39315.2 - 0.074 12.5 1.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase RRN3 PF05327.11 EDK39315.2 - 3 6.3 7.6 4.2 5.8 7.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EDK39315.2 - 5.7 5.1 6.1 9.1 4.4 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein HLH PF00010.26 EDK39316.2 - 7.4e-18 64.3 0.0 1.5e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Nucleo_P87 PF07267.11 EDK39316.2 - 0.047 12.6 3.4 0.053 12.4 3.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 p450 PF00067.22 EDK39317.1 - 7.2e-89 298.6 0.0 8.5e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GHMP_kinases_N PF00288.26 EDK39318.2 - 1.1e-09 38.4 0.0 2.1e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDK39318.2 - 0.011 16.1 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 0 GHMP kinases C terminal Bac_surface_Ag PF01103.23 EDK39319.2 - 5.6e-08 32.7 11.2 1.2e-07 31.6 11.1 1.5 1 1 0 1 1 1 1 Surface antigen RabGAP-TBC PF00566.18 EDK39320.2 - 1.6e-17 63.9 0.7 3.2e-17 62.9 0.7 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Elf1 PF05129.13 EDK39321.2 - 1.6e-30 105.0 2.5 2.1e-30 104.6 2.5 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Ribosomal_L37ae PF01780.19 EDK39321.2 - 0.04 14.0 0.3 0.063 13.4 0.3 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family Zn-ribbon_8 PF09723.10 EDK39321.2 - 0.092 12.9 1.7 0.61 10.3 2.1 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Imm71 PF15602.6 EDK39321.2 - 0.1 12.6 0.1 0.16 12.0 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 71 zf-Sec23_Sec24 PF04810.15 EDK39321.2 - 2.2 8.4 5.6 5.6 7.1 0.7 2.3 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger LRR_4 PF12799.7 EDK39322.2 - 0.045 14.2 19.8 0.15 12.5 3.1 6.2 6 1 0 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDK39322.2 - 0.56 11.0 13.0 2 9.3 0.3 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EDK39322.2 - 0.61 9.9 10.4 0.38 10.5 1.1 4.4 4 0 0 4 4 4 0 Leucine rich repeat LRR_6 PF13516.6 EDK39322.2 - 3.2 8.0 7.4 40 4.6 0.4 5.5 6 0 0 6 6 6 0 Leucine Rich repeat MFS_1 PF07690.16 EDK39323.2 - 3.2e-13 49.3 2.2 1.4e-07 30.8 0.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDK39323.2 - 0.0012 17.8 4.5 0.011 14.6 0.3 2.4 2 1 1 3 3 3 2 MFS_1 like family DUF3169 PF11368.8 EDK39323.2 - 0.011 15.3 0.3 0.057 12.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) FAM176 PF14851.6 EDK39323.2 - 0.19 11.4 2.4 0.36 10.5 0.1 2.4 3 0 0 3 3 3 0 FAM176 family SRP54 PF00448.22 EDK39324.2 - 1.1e-77 260.1 1.9 3.9e-77 258.3 0.6 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EDK39324.2 - 1.1e-26 93.3 6.3 1.1e-26 93.3 6.3 4.6 4 1 0 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.19 EDK39324.2 - 1.2e-18 67.1 3.9 2.8e-18 65.9 3.9 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EDK39324.2 - 5.3e-07 29.4 2.1 0.0012 18.5 0.9 3.4 2 1 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EDK39324.2 - 1.5e-05 25.2 0.2 3.6e-05 24.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain CbiA PF01656.23 EDK39324.2 - 0.00013 22.0 0.0 0.001 19.1 0.0 2.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 EDK39324.2 - 0.0024 17.8 0.0 0.0075 16.2 0.0 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 EDK39324.2 - 0.0078 15.2 0.0 0.0078 15.2 0.0 3.1 4 0 0 4 4 4 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 EDK39324.2 - 0.0094 15.9 0.5 0.12 12.3 0.3 2.4 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EDK39324.2 - 0.02 15.4 0.1 0.099 13.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain MipZ PF09140.11 EDK39324.2 - 0.021 14.1 0.2 5.7 6.1 0.0 2.5 2 0 0 2 2 2 0 ATPase MipZ APS_kinase PF01583.20 EDK39324.2 - 0.022 14.6 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase SRPRB PF09439.10 EDK39324.2 - 0.022 14.2 4.9 4.6 6.6 0.0 3.9 4 0 0 4 4 4 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EDK39324.2 - 0.03 14.7 0.0 0.09 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain 6PF2K PF01591.18 EDK39324.2 - 0.049 12.9 0.1 0.12 11.7 0.1 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_17 PF13207.6 EDK39324.2 - 0.06 13.8 0.1 0.06 13.8 0.1 3.5 4 0 0 4 4 4 0 AAA domain VirC1 PF07015.11 EDK39324.2 - 0.14 11.4 0.9 0.23 10.7 0.0 1.7 2 0 0 2 2 1 0 VirC1 protein NTPase_1 PF03266.15 EDK39324.2 - 0.14 12.0 1.7 0.54 10.2 0.2 2.4 1 1 1 2 2 2 0 NTPase STI1 PF17830.1 EDK39324.2 - 0.24 11.4 42.1 0.21 11.5 23.7 3.4 3 0 0 3 3 3 0 STI1 domain AAA_22 PF13401.6 EDK39324.2 - 0.26 11.5 1.3 0.84 9.9 0.3 2.4 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDK39324.2 - 0.28 10.7 0.8 2.1 7.9 0.1 2.3 1 1 1 2 2 2 0 AAA domain XPC-binding PF09280.11 EDK39324.2 - 0.35 10.6 21.3 2.9 7.7 0.2 3.5 2 1 1 3 3 3 0 XPC-binding domain AAA PF00004.29 EDK39324.2 - 1.4 9.3 4.8 2.9 8.3 0.5 3.3 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DUF4938 PF16292.5 EDK39325.2 - 0.017 14.4 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4938) Peptidase_A22B PF04258.13 EDK39326.2 - 3.6e-63 213.8 6.5 8.2e-63 212.6 6.5 1.6 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EDK39326.2 - 1.9e-06 27.6 3.6 1.9e-06 27.6 3.6 1.6 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease KH_1 PF00013.29 EDK39328.2 - 8.3e-38 128.1 0.4 4.5e-15 55.2 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EDK39328.2 - 7.1e-10 38.6 2.1 0.0013 18.6 0.0 3.7 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 EDK39328.2 - 8.9e-10 38.3 3.3 0.046 13.6 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EDK39328.2 - 9.1e-08 32.1 2.5 0.32 11.1 0.4 3.3 3 0 0 3 3 3 3 NusA-like KH domain SLS PF14611.6 EDK39328.2 - 0.0013 18.6 0.0 0.035 13.9 0.0 2.3 1 1 0 2 2 2 1 Mitochondrial inner-membrane-bound regulator MOEP19 PF16005.5 EDK39328.2 - 0.038 14.0 0.0 0.48 10.5 0.0 2.6 3 1 1 4 4 4 0 KH-like RNA-binding domain GAF_2 PF13185.6 EDK39329.1 - 3.5e-10 40.3 0.0 5.4e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EDK39329.1 - 0.00066 20.3 0.0 0.0008 20.0 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EDK39329.1 - 0.038 14.3 0.0 0.067 13.5 0.0 1.5 1 1 0 1 1 1 0 GAF domain CRT10 PF08728.10 EDK39330.2 - 1.3e-194 648.4 1.3 1.1e-132 443.7 0.1 2.5 2 1 1 3 3 3 2 CRT10 Suf PF05843.14 EDK39330.2 - 0.37 10.7 5.6 0.77 9.7 5.6 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CENP-C_C PF11699.8 EDK39331.2 - 2.3e-21 75.8 0.2 4.3e-21 74.9 0.2 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EDK39331.2 - 5.1e-06 26.1 0.1 9.5e-06 25.2 0.1 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 EDK39331.2 - 0.013 15.4 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase V-SNARE_C PF12352.8 EDK39331.2 - 0.066 13.5 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Mif2_N PF15624.6 EDK39331.2 - 0.13 13.0 22.6 0.37 11.5 16.4 3.6 2 1 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal PH_12 PF16457.5 EDK39331.2 - 0.33 11.5 1.6 0.43 11.1 0.0 2.0 3 0 0 3 3 3 0 Pleckstrin homology domain RL10P_insert PF17777.1 EDK39332.2 - 2.8e-20 72.1 0.0 4.3e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDK39332.2 - 4.9e-15 55.5 0.0 2.1e-14 53.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L10 Complex1_LYR PF05347.15 EDK39334.1 - 6.4e-09 35.7 1.2 9.8e-09 35.1 1.2 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) CH PF00307.31 EDK39335.2 - 3.3e-81 268.6 0.1 3.9e-22 78.5 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EDK39335.2 - 1.5e-08 34.3 0.0 0.52 10.2 0.0 4.4 4 0 0 4 4 4 4 CAMSAP CH domain CH_2 PF06294.11 EDK39335.2 - 2.2e-05 24.5 0.1 2.7 8.2 0.0 4.0 4 1 0 4 4 4 2 CH-like domain in sperm protein EF-hand_1 PF00036.32 EDK39335.2 - 0.00016 21.0 0.0 0.0088 15.5 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EDK39335.2 - 0.0027 18.1 0.8 0.007 16.8 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair Pep3_Vps18 PF05131.14 EDK39336.2 - 1.5e-25 89.8 0.1 4.1e-25 88.3 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Vps39_2 PF10367.9 EDK39336.2 - 5.8e-06 26.7 0.7 2.1e-05 24.9 0.7 2.1 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Zn_ribbon_17 PF17120.5 EDK39336.2 - 0.0023 17.5 0.9 0.0023 17.5 0.9 1.6 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EDK39336.2 - 0.0062 16.8 3.4 0.018 15.4 3.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDK39336.2 - 0.008 16.4 1.6 0.025 14.8 1.6 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDK39336.2 - 0.013 15.4 3.3 0.036 13.9 3.3 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EDK39336.2 - 0.017 15.4 3.3 0.036 14.4 3.3 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 EDK39336.2 - 0.036 13.9 3.7 0.097 12.6 3.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK39336.2 - 0.039 14.0 3.3 0.11 12.5 3.3 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EDK39336.2 - 0.047 13.4 8.9 0.13 12.0 8.9 1.8 1 0 0 1 1 1 0 RING-like zinc finger TPR_1 PF00515.28 EDK39336.2 - 0.13 12.1 0.3 0.47 10.4 0.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat PHD PF00628.29 EDK39336.2 - 0.32 10.9 2.9 0.85 9.6 2.9 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 EDK39336.2 - 0.6 10.1 3.7 1.5 8.8 3.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Spb1_C PF07780.12 EDK39337.2 - 1.8e-79 266.3 22.3 1.8e-79 266.3 22.3 3.2 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EDK39337.2 - 9.5e-53 178.9 0.0 1.9e-52 177.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EDK39337.2 - 8.6e-43 146.0 13.8 8.6e-43 146.0 13.8 5.1 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) Latarcin PF10279.9 EDK39337.2 - 0.0025 18.2 6.2 0.19 12.2 4.0 3.6 2 1 0 2 2 2 1 Latarcin precursor ATP_transf PF09830.9 EDK39339.1 - 4.1e-16 58.9 0.0 6.9e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 EDK39339.1 - 0.00038 21.1 0.0 0.0014 19.3 0.0 1.9 2 0 0 2 2 2 1 HIT domain DUF4922 PF16269.5 EDK39339.1 - 0.0028 17.4 0.1 0.0059 16.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4922) DUF4931 PF16285.5 EDK39339.1 - 0.0032 16.8 0.1 0.0068 15.7 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4931) UCR_14kD PF02271.16 EDK39340.2 - 7.8e-37 125.3 0.0 9.2e-37 125.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EDK39341.2 - 1e-57 192.0 1.9 1.8e-18 66.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.24 EDK39342.2 - 2.2e-36 125.7 29.9 8.3e-36 123.8 29.9 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39342.2 - 4.8e-32 111.3 32.1 4.8e-32 111.3 32.1 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK39343.2 - 2.2e-38 132.3 21.3 2.8e-37 128.7 21.3 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39343.2 - 4.2e-35 121.3 24.8 4.2e-35 121.3 24.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Histone PF00125.24 EDK39344.1 - 4.7e-20 72.3 4.0 6.6e-20 71.8 4.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDK39344.1 - 1.7e-07 31.4 0.9 3.6e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDK39344.1 - 0.0015 18.9 0.0 0.0028 18.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 EDK39344.1 - 0.0025 17.8 1.0 0.0032 17.5 1.0 1.2 1 0 0 1 1 1 1 YscO-like protein NFACT-R_2 PF18297.1 EDK39344.1 - 0.0048 17.1 0.1 0.0084 16.3 0.1 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain CENP-W PF15510.6 EDK39344.1 - 0.025 14.8 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 CENP-W protein DUF3391 PF11871.8 EDK39344.1 - 0.33 11.5 3.3 0.56 10.8 3.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Histone_H2A_C PF16211.5 EDK39345.1 - 5e-21 74.1 1.3 8.7e-21 73.4 1.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDK39345.1 - 8.5e-17 61.7 0.0 1.1e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDK39345.1 - 4.2e-05 23.8 0.0 5.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Acid_PPase PF12689.7 EDK39346.2 - 3.9e-55 186.3 0.0 4.6e-55 186.0 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase ZZ PF00569.17 EDK39347.2 - 1.5e-09 37.5 5.3 3.3e-09 36.4 5.3 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type Ig_GlcNase PF18368.1 EDK39347.2 - 0.017 15.3 0.0 0.09 12.9 0.0 2.1 2 0 0 2 2 2 0 Exo-beta-D-glucosaminidase Ig-fold domain Merozoite_SPAM PF07133.11 EDK39348.2 - 0.18 11.8 1.0 0.38 10.7 1.0 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF5638 PF18688.1 EDK39349.2 - 0.026 14.8 0.3 0.063 13.6 0.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5638) Snapin_Pallidin PF14712.6 EDK39349.2 - 0.33 11.4 3.5 0.55 10.7 0.2 2.7 2 1 1 3 3 3 0 Snapin/Pallidin DRIM PF07539.12 EDK39350.2 - 1.1e-132 443.5 11.8 1.1e-132 443.5 11.8 3.5 3 1 2 5 5 5 1 Down-regulated in metastasis DUF155 PF02582.14 EDK39351.2 - 1.6e-56 191.2 1.2 7.1e-56 189.1 1.8 1.7 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EDK39351.2 - 0.02 15.4 0.2 0.066 13.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 STE PF02200.16 EDK39352.2 - 0.00062 20.2 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 STE like transcription factor DUF846 PF05832.12 EDK39352.2 - 0.14 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF846) AIM24 PF01987.17 EDK39353.2 - 9.1e-23 81.1 0.1 1.2e-22 80.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 PIP5K PF01504.18 EDK39354.2 - 3.8e-95 318.2 0.2 3.8e-95 318.2 0.2 2.1 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3836 PF12930.7 EDK39354.2 - 0.1 12.4 0.1 0.1 12.4 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF3836) Suc_Fer-like PF06999.12 EDK39355.2 - 3.9e-52 177.0 0.0 4.6e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Thioredoxin PF00085.20 EDK39356.2 - 4.7e-32 110.0 0.1 1.4e-21 76.4 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 EDK39356.2 - 5.3e-14 52.3 0.2 1.3e-08 34.6 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDK39356.2 - 2.2e-10 40.9 0.1 0.00018 21.9 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDK39356.2 - 2.8e-10 40.4 0.3 2.1e-06 28.0 0.1 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EDK39356.2 - 5.5e-06 26.5 0.1 0.022 14.9 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like TraF PF13728.6 EDK39356.2 - 0.0019 18.1 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 2 F plasmid transfer operon protein ERp29_N PF07912.13 EDK39356.2 - 0.0028 17.8 0.9 0.01 16.0 0.5 2.2 2 1 0 2 2 2 1 ERp29, N-terminal domain Glutaredoxin PF00462.24 EDK39356.2 - 0.0046 17.2 0.0 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 Glutaredoxin HyaE PF07449.11 EDK39356.2 - 0.088 12.8 0.0 14 5.7 0.0 2.4 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 EDK39356.2 - 0.091 12.8 0.0 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin domain Fer4_4 PF12800.7 EDK39356.2 - 5.2 7.8 4.9 28 5.5 0.3 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain DUF836 PF05768.14 EDK39357.1 - 5.1e-13 49.2 0.3 6.9e-13 48.8 0.3 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EDK39357.1 - 0.00019 21.6 0.1 0.00038 20.6 0.1 1.6 1 1 0 1 1 1 1 Glutaredoxin adh_short PF00106.25 EDK39358.1 - 7.6e-20 71.2 0.0 1.2e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39358.1 - 1.4e-11 44.4 0.0 1.8e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EDK39358.1 - 0.0051 16.2 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) FERM_F2 PF18377.1 EDK39358.1 - 0.087 12.8 0.0 0.53 10.2 0.0 1.9 1 1 1 2 2 2 0 FERM F2 acyl-CoA binding protein-like domain adh_short PF00106.25 EDK39359.2 - 7.6e-39 133.2 0.0 1.2e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39359.2 - 1.4e-22 80.4 0.0 1.7e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK39359.2 - 0.00034 20.6 0.0 0.00064 19.7 0.0 1.4 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EDK39359.2 - 0.0047 16.7 0.1 0.0084 15.9 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 EDK39359.2 - 0.019 14.4 0.0 0.028 13.9 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 EDK39360.2 - 6.3e-21 75.4 0.0 1e-20 74.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDK39360.2 - 2.1e-11 43.8 0.0 4.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 EDK39360.2 - 0.064 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDK39360.2 - 0.13 12.3 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF676 PF05057.14 EDK39361.2 - 1.3e-36 126.2 0.0 2.7e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 EDK39361.2 - 0.073 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase RRN3 PF05327.11 EDK39361.2 - 4.9 5.6 7.6 33 2.8 7.6 1.9 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Transket_pyr PF02779.24 EDK39362.2 - 3.5e-66 222.2 0.0 5.8e-66 221.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EDK39362.2 - 4.8e-56 189.9 0.0 7.8e-56 189.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EDK39362.2 - 5.2e-52 175.6 0.0 8.3e-52 174.9 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EDK39362.2 - 2.5e-20 71.8 1.5 2.5e-20 71.8 1.5 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Aminotran_1_2 PF00155.21 EDK39363.2 - 2.8e-38 132.1 0.0 3.7e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PQQ PF01011.21 EDK39364.2 - 0.032 14.1 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat LRR_4 PF12799.7 EDK39364.2 - 0.27 11.7 17.9 1 9.9 0.2 5.4 3 1 3 6 6 6 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK39364.2 - 1 9.6 12.2 8.6 6.7 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 EDK39364.2 - 7.9 6.3 13.3 1.4 8.7 1.1 4.7 5 1 0 5 5 5 0 Leucine rich repeat Sod_Cu PF00080.20 EDK39365.2 - 1.4e-14 54.5 0.0 2.2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) APH PF01636.23 EDK39366.2 - 5.1e-36 124.8 0.0 6.6e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EDK39366.2 - 1.9e-07 30.7 0.0 2.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDK39366.2 - 1e-05 25.3 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EDK39366.2 - 0.00034 19.6 0.0 0.00048 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 EDK39366.2 - 0.0086 15.3 0.0 0.037 13.2 0.0 2.0 1 1 0 1 1 1 1 Fructosamine kinase APH_6_hur PF04655.14 EDK39366.2 - 0.014 14.8 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Mss4 PF04421.13 EDK39368.2 - 1.1e-14 54.4 0.1 1.2e-14 54.2 0.1 1.1 1 0 0 1 1 1 1 Mss4 protein GMC_oxred_N PF00732.19 EDK39369.2 - 1.9e-61 208.1 0.1 2.6e-61 207.6 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDK39369.2 - 1.4e-22 80.8 0.1 8.3e-22 78.3 0.0 2.2 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDK39369.2 - 4.1e-06 26.1 0.1 1.1e-05 24.8 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDK39369.2 - 0.0047 17.1 0.2 0.014 15.6 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Flo11 PF10182.9 EDK39369.2 - 0.026 14.7 0.4 0.053 13.7 0.4 1.4 1 0 0 1 1 1 0 Flo11 domain Pyr_redox_2 PF07992.14 EDK39369.2 - 0.13 11.5 0.0 1.2 8.3 0.0 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HVSL PF09749.9 EDK39370.2 - 1.5e-06 27.9 1.2 3e-06 26.9 1.2 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein ArfGap PF01412.18 EDK39371.2 - 1.5e-29 102.4 0.0 1.5e-29 102.4 0.0 2.5 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf UBA PF00627.31 EDK39371.2 - 0.00083 19.2 0.1 0.0043 16.9 0.0 2.3 3 0 0 3 3 3 1 UBA/TS-N domain TFIIA PF03153.13 EDK39371.2 - 0.61 10.0 51.6 1.1 9.2 51.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_2 PF07724.14 EDK39372.2 - 2.3e-47 161.3 0.2 9e-45 152.9 0.0 3.6 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDK39372.2 - 1.3e-29 102.2 0.9 1.3e-29 102.2 0.9 2.7 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EDK39372.2 - 5.6e-23 80.8 0.5 2e-22 79.1 0.5 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDK39372.2 - 1.5e-22 80.5 0.1 2.1e-12 47.6 0.1 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK39372.2 - 1.4e-14 54.3 0.0 3.9e-09 36.6 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 EDK39372.2 - 4.2e-12 46.0 0.4 4.9e-09 36.2 0.1 3.6 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 EDK39372.2 - 9.5e-12 44.9 0.4 1.6e-06 27.9 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 EDK39372.2 - 2.4e-10 41.1 7.4 1e-05 26.0 0.4 4.5 3 2 2 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 EDK39372.2 - 3.9e-07 30.4 0.4 0.016 15.4 0.1 3.7 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EDK39372.2 - 3.3e-06 27.1 0.0 0.18 11.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain TniB PF05621.11 EDK39372.2 - 1.6e-05 24.4 0.0 0.0051 16.2 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein Mg_chelatase PF01078.21 EDK39372.2 - 2.2e-05 24.0 0.1 1 8.7 0.0 3.4 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDK39372.2 - 0.00011 22.2 0.1 0.036 14.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 EDK39372.2 - 0.00014 21.4 0.0 0.028 13.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EDK39372.2 - 0.00042 20.2 0.0 0.16 11.9 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EDK39372.2 - 0.0011 19.2 0.1 0.26 11.4 0.0 3.4 3 0 0 3 3 2 1 AAA domain ATPase_2 PF01637.18 EDK39372.2 - 0.0014 18.6 10.9 0.084 12.8 0.2 4.5 4 2 1 5 5 4 2 ATPase domain predominantly from Archaea TsaE PF02367.17 EDK39372.2 - 0.0019 18.2 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EDK39372.2 - 0.0023 18.1 0.0 0.6 10.3 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EDK39372.2 - 0.0037 17.0 0.1 0.46 10.2 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_24 PF13479.6 EDK39372.2 - 0.0049 16.6 0.0 2.6 7.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EDK39372.2 - 0.0063 16.2 0.1 0.56 9.8 0.0 3.2 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_8 PF12780.7 EDK39372.2 - 0.0066 15.8 1.1 0.58 9.4 0.6 3.1 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_3 PF07726.11 EDK39372.2 - 0.0081 16.0 0.0 0.23 11.3 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDK39372.2 - 0.018 14.3 0.0 0.39 10.0 0.0 2.9 3 0 0 3 3 2 0 Zeta toxin AAA_30 PF13604.6 EDK39372.2 - 0.018 14.7 5.1 0.052 13.3 0.1 3.5 4 0 0 4 4 3 0 AAA domain AAA_29 PF13555.6 EDK39372.2 - 0.027 14.2 0.2 4.2 7.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.11 EDK39372.2 - 0.03 14.4 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Torsin ABC_tran PF00005.27 EDK39372.2 - 0.03 14.8 1.4 5.2 7.6 0.0 3.1 3 0 0 3 3 2 0 ABC transporter APS_kinase PF01583.20 EDK39372.2 - 0.036 14.0 0.1 0.25 11.2 0.0 2.4 3 0 0 3 3 2 0 Adenylylsulphate kinase AAA_19 PF13245.6 EDK39372.2 - 0.036 14.4 0.8 0.62 10.4 0.3 3.2 3 1 0 3 3 2 0 AAA domain DUF815 PF05673.13 EDK39372.2 - 0.044 12.9 1.2 0.95 8.6 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF815) PEPCK_ATP PF01293.20 EDK39372.2 - 0.049 12.3 0.0 0.22 10.2 0.0 1.9 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase RNA_helicase PF00910.22 EDK39372.2 - 0.13 12.7 0.0 27 5.2 0.0 3.0 3 0 0 3 3 2 0 RNA helicase NB-ARC PF00931.22 EDK39372.2 - 0.14 11.3 0.8 2.6 7.1 0.0 2.9 2 1 1 3 3 3 0 NB-ARC domain AAA_18 PF13238.6 EDK39372.2 - 0.16 12.5 5.9 3.4 8.2 0.3 4.1 4 1 0 4 4 3 0 AAA domain AAA_28 PF13521.6 EDK39372.2 - 0.23 11.7 3.4 36 4.5 0.0 4.0 3 1 0 3 3 3 0 AAA domain V_ATPase_I PF01496.19 EDK39372.2 - 2.6 5.9 4.8 4.2 5.2 4.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-6 PF01912.18 EDK39373.1 - 1.6e-82 275.7 0.9 2e-82 275.4 0.9 1.1 1 0 0 1 1 1 1 eIF-6 family PI3_PI4_kinase PF00454.27 EDK39374.2 - 1.1e-39 136.8 0.0 1.7e-37 129.6 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDK39374.2 - 1.4e-24 86.5 0.1 7.4e-24 84.2 0.0 2.2 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) TRP PF06011.12 EDK39375.2 - 1.6e-155 518.1 31.7 1.6e-155 518.1 31.7 1.5 2 0 0 2 2 2 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EDK39375.2 - 8.8e-41 139.5 0.2 1.7e-40 138.6 0.2 1.5 1 0 0 1 1 1 1 ML-like domain Tnp_22_trimer PF17489.2 EDK39376.2 - 0.0042 17.0 0.1 0.0042 17.0 0.1 1.8 2 0 0 2 2 2 1 L1 transposable element trimerization domain DUF883 PF05957.13 EDK39376.2 - 0.093 13.3 1.3 0.18 12.4 0.9 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MARVEL PF01284.23 EDK39377.2 - 3e-05 24.1 12.7 4.6e-05 23.5 12.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain Cas1_AcylT PF07779.12 EDK39377.2 - 0.059 12.3 5.8 0.082 11.8 5.8 1.1 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p SieB PF14163.6 EDK39377.2 - 0.6 9.6 5.2 2.6 7.6 0.1 2.2 2 0 0 2 2 2 0 Super-infection exclusion protein B 2-oxoacid_dh PF00198.23 EDK39378.1 - 1.2e-80 270.3 0.1 1.8e-80 269.8 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDK39378.1 - 1.1e-19 70.0 3.4 2.1e-19 69.1 3.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDK39378.1 - 2.6e-07 30.3 0.2 0.00018 21.3 0.1 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 EDK39378.1 - 1.5e-05 25.6 0.5 0.002 18.8 0.1 2.5 1 1 1 2 2 2 1 HlyD family secretion protein GCV_H PF01597.19 EDK39378.1 - 1.8e-05 24.6 1.0 4.7e-05 23.3 1.0 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 EDK39378.1 - 0.00019 21.3 0.7 0.0065 16.4 0.1 2.7 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain Presenilin PF01080.17 EDK39378.1 - 0.01 14.6 7.0 0.015 14.1 7.0 1.2 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 EDK39378.1 - 0.039 14.1 13.9 0.062 13.4 13.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RNA_pol_Rpc4 PF05132.14 EDK39378.1 - 0.078 13.4 9.7 0.13 12.6 9.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 EDK39378.1 - 0.11 10.8 9.8 0.14 10.4 9.8 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EDK39378.1 - 0.35 10.7 15.3 0.49 10.2 15.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 EDK39378.1 - 0.47 10.6 7.6 1.1 9.5 7.6 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HlyD_D23 PF16576.5 EDK39378.1 - 0.5 9.5 6.7 1.6 7.9 6.3 2.1 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GAGA_bind PF06217.12 EDK39378.1 - 1.9 8.7 9.1 2.9 8.1 9.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Ndc1_Nup PF09531.10 EDK39378.1 - 2 7.0 4.9 2.6 6.6 4.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Vfa1 PF08432.10 EDK39378.1 - 2.6 8.3 18.5 4.4 7.6 18.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Neur_chan_memb PF02932.16 EDK39378.1 - 2.7 8.0 5.1 3.6 7.6 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SspB PF04386.13 EDK39378.1 - 3 7.7 9.4 6.3 6.7 9.4 1.6 1 0 0 1 1 1 0 Stringent starvation protein B Tim54 PF11711.8 EDK39378.1 - 4.5 5.9 14.7 7.1 5.3 14.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 zf-C2H2 PF00096.26 EDK39379.2 - 5.4e-10 39.2 25.9 3.4e-05 24.1 2.5 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK39379.2 - 8.2e-07 29.3 22.2 0.0016 19.1 1.2 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK39379.2 - 0.0001 22.6 0.4 0.0001 22.6 0.4 4.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDK39379.2 - 0.0024 17.8 9.2 0.085 12.9 0.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger Imm27 PF15590.6 EDK39379.2 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 27 zf-C2H2_jaz PF12171.8 EDK39379.2 - 0.36 11.2 6.9 0.58 10.5 0.3 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 EDK39379.2 - 0.89 10.3 11.1 0.075 13.7 2.5 2.3 1 1 1 2 2 2 0 TRAF-type zinc finger zf-C2H2 PF00096.26 EDK39380.2 - 1.4e-10 41.0 15.8 6.6e-05 23.1 2.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK39380.2 - 4.7e-08 33.1 14.8 2e-06 27.9 5.9 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK39380.2 - 3.4e-07 30.5 14.6 0.004 17.9 5.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK39380.2 - 2.3e-05 24.5 9.7 0.016 15.5 1.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDK39380.2 - 5.1e-05 23.5 9.4 0.0024 18.2 2.1 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDK39380.2 - 0.00029 20.8 10.6 0.022 14.7 1.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 EDK39380.2 - 0.0014 18.9 4.4 0.0023 18.2 4.4 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 EDK39380.2 - 0.0024 17.8 9.2 0.014 15.4 3.7 2.5 1 1 1 2 2 2 2 BED zinc finger zf-C2H2_3rep PF18868.1 EDK39380.2 - 0.018 15.7 2.1 0.018 15.7 2.1 2.0 2 0 0 2 2 1 0 Zinc finger C2H2-type, 3 repeats zf-MYST PF17772.1 EDK39380.2 - 0.24 11.1 9.9 0.42 10.2 0.6 3.3 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2H2_2 PF12756.7 EDK39380.2 - 0.33 11.3 7.2 3.8 7.9 0.5 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 EDK39380.2 - 2.2 8.3 6.2 7.3 6.6 0.5 2.6 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.5 EDK39380.2 - 3.5 8.2 9.3 1.4 9.4 1.2 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EDK39380.2 - 5.3 6.9 10.8 4.4 7.2 0.6 3.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Kelch_3 PF13415.6 EDK39381.2 - 2e-05 24.8 0.0 0.00059 20.1 0.0 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EDK39381.2 - 2.3e-05 24.5 0.1 0.00037 20.7 0.0 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EDK39381.2 - 0.00012 22.0 0.0 0.027 14.5 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Gram_pos_anchor PF00746.21 EDK39381.2 - 0.093 12.7 1.0 0.22 11.5 1.0 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif SKG6 PF08693.10 EDK39381.2 - 1.9 8.0 4.1 0.49 9.8 0.5 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Chorismate_synt PF01264.21 EDK39382.2 - 3.6e-138 459.7 0.0 4.1e-138 459.6 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SRPRB PF09439.10 EDK39383.2 - 4.1e-30 104.6 0.0 5e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EDK39383.2 - 7e-09 35.4 0.0 1.7e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDK39383.2 - 3e-06 27.3 0.0 4.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EDK39383.2 - 8.4e-06 25.7 0.2 0.00079 19.3 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EDK39383.2 - 9e-06 25.4 0.0 0.00014 21.5 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDK39383.2 - 1.1e-05 25.0 0.1 1.4e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EDK39383.2 - 0.00078 19.6 0.0 0.0015 18.8 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK39383.2 - 0.0032 17.1 0.0 0.0059 16.2 0.0 1.4 1 1 0 1 1 1 1 Ras family AAA_22 PF13401.6 EDK39383.2 - 0.02 15.2 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EDK39383.2 - 0.022 14.8 0.1 3.9 7.5 0.1 2.4 1 1 1 2 2 2 0 Dynamin family AAA_23 PF13476.6 EDK39383.2 - 0.022 15.2 0.2 0.15 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDK39383.2 - 0.026 14.4 0.1 0.56 10.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Flp_Fap PF04964.14 EDK39383.2 - 0.052 13.4 2.7 0.11 12.3 1.7 2.0 2 0 0 2 2 2 0 Flp/Fap pilin component Septin PF00735.18 EDK39383.2 - 0.071 12.4 0.0 0.51 9.6 0.0 2.0 2 0 0 2 2 2 0 Septin Vfa1 PF08432.10 EDK39384.2 - 4.3e-44 151.0 6.4 4.9e-44 150.8 6.4 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Not3 PF04065.15 EDK39384.2 - 0.0021 17.5 2.6 0.0026 17.2 2.6 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Nas2_N PF18265.1 EDK39384.2 - 0.0062 16.4 1.8 2.1 8.3 0.2 2.3 2 0 0 2 2 2 2 Nas2 N_terminal domain Tropomyosin_1 PF12718.7 EDK39384.2 - 0.015 15.4 2.2 1.7 8.8 0.0 2.1 2 0 0 2 2 2 0 Tropomyosin like FlxA PF14282.6 EDK39384.2 - 0.026 14.5 1.8 0.43 10.6 0.0 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF4140 PF13600.6 EDK39384.2 - 0.03 14.8 0.2 5.7 7.4 0.2 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) LRS4 PF10422.9 EDK39384.2 - 0.047 13.3 1.9 0.062 12.9 1.9 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Cep57_CLD_2 PF14197.6 EDK39384.2 - 0.047 13.8 0.6 0.77 9.9 0.1 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF1664 PF07889.12 EDK39384.2 - 0.056 13.5 0.2 13 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fungal_TACC PF12709.7 EDK39384.2 - 0.063 13.7 4.3 6 7.4 2.1 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4407 PF14362.6 EDK39384.2 - 0.086 12.2 0.5 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 EDK39384.2 - 0.095 11.3 2.7 0.12 11.0 2.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4962 PF16332.5 EDK39384.2 - 0.1 11.1 2.4 0.13 10.7 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) DUF5082 PF16888.5 EDK39384.2 - 0.12 12.7 2.3 1.8 8.8 0.1 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) GreA_GreB_N PF03449.15 EDK39384.2 - 0.21 11.7 3.6 6.7 6.9 0.3 2.2 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal ABC_tran_CTD PF16326.5 EDK39384.2 - 0.29 11.4 6.0 5.3 7.4 0.5 2.6 2 1 1 3 3 3 0 ABC transporter C-terminal domain DHR10 PF18595.1 EDK39384.2 - 0.34 11.0 6.6 2.7 8.1 0.6 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF5320 PF17253.2 EDK39384.2 - 0.35 12.0 3.9 0.47 11.6 0.6 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Med30 PF11315.8 EDK39384.2 - 0.49 10.6 6.3 1.2 9.3 1.4 2.1 1 1 1 2 2 2 0 Mediator complex subunit 30 Prefoldin_2 PF01920.20 EDK39384.2 - 0.49 10.4 7.9 6.1 6.9 0.0 2.5 2 1 1 3 3 3 0 Prefoldin subunit APG6_N PF17675.1 EDK39384.2 - 1.1 9.8 8.4 26 5.3 8.4 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region BBS2_C PF14782.6 EDK39384.2 - 1.5 7.5 8.1 0.26 10.0 2.3 2.0 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal BST2 PF16716.5 EDK39384.2 - 4.6 7.9 8.0 19 5.9 1.0 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF2681 PF10883.8 EDK39384.2 - 5.9 7.4 7.4 0.85 10.1 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Metallophos PF00149.28 EDK39385.1 - 1.6e-40 139.8 0.1 2.1e-40 139.4 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDK39385.1 - 3.2e-22 78.7 0.7 5.8e-22 77.9 0.4 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Ribosomal_S27e PF01667.17 EDK39386.1 - 2.9e-26 90.9 6.3 3.1e-26 90.8 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 zinc_ribbon_4 PF13717.6 EDK39386.1 - 0.092 12.7 3.2 5.1 7.1 3.2 2.5 1 1 0 1 1 1 0 zinc-ribbon domain Aminotran_1_2 PF00155.21 EDK39387.1 - 2.7e-76 257.1 0.0 3.1e-76 256.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Torus PF16131.5 EDK39387.1 - 0.11 13.2 0.0 0.23 12.2 0.0 1.4 1 0 0 1 1 1 0 Torus domain PsiB PF06290.11 EDK39387.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Plasmid SOS inhibition protein (PsiB) Crp PF00325.20 EDK39387.1 - 0.15 11.7 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family RTA1 PF04479.13 EDK39388.2 - 2e-29 102.7 4.2 2.4e-29 102.4 4.2 1.1 1 0 0 1 1 1 1 RTA1 like protein CTV_P6 PF06706.11 EDK39388.2 - 0.059 13.1 0.1 0.059 13.1 0.1 2.4 3 0 0 3 3 3 0 Citrus tristeza virus 6-kDa protein DUF1240 PF06836.12 EDK39388.2 - 0.067 13.7 1.9 10 6.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1240) RTA1 PF04479.13 EDK39389.2 - 1e-30 106.9 3.1 1.5e-30 106.4 3.1 1.1 1 0 0 1 1 1 1 RTA1 like protein EMP24_GP25L PF01105.24 EDK39390.2 - 2.2e-46 158.1 0.8 2.5e-46 157.9 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4793 PF16041.5 EDK39390.2 - 0.0005 20.2 0.5 0.0013 18.8 0.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4793) Pkinase PF00069.25 EDK39391.2 - 5.7e-69 232.4 0.0 7e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39391.2 - 1.2e-34 119.7 0.0 2e-34 119.0 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDK39391.2 - 0.00016 21.1 0.3 0.00025 20.5 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDK39391.2 - 0.00033 19.7 0.5 0.00048 19.2 0.5 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EDK39391.2 - 0.0011 18.6 0.3 0.67 9.5 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDK39391.2 - 0.009 16.0 0.6 0.14 12.0 0.2 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDK39391.2 - 0.038 13.1 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 EDK39391.2 - 0.04 13.2 0.2 0.092 12.1 0.1 1.6 1 1 0 1 1 1 0 Kinase-like DUF2406 PF10295.9 EDK39392.1 - 9.3e-28 96.7 3.8 2.2e-27 95.5 1.0 2.4 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) TPR_2 PF07719.17 EDK39393.2 - 2.8e-05 23.9 0.1 0.065 13.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDK39393.2 - 0.00042 20.0 1.0 0.052 13.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK39393.2 - 0.0011 19.2 1.3 0.022 15.0 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 EDK39393.2 - 0.013 15.5 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) EF-hand_like PF09279.11 EDK39393.2 - 0.018 15.5 0.2 0.059 13.9 0.2 1.8 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like ANAPC3 PF12895.7 EDK39393.2 - 0.023 14.9 0.3 0.061 13.5 0.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDK39393.2 - 0.024 14.8 2.4 0.96 9.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Death PF00531.22 EDK39393.2 - 0.25 11.5 1.7 0.43 10.8 0.1 2.2 3 0 0 3 3 3 0 Death domain MIT PF04212.18 EDK39393.2 - 0.53 10.4 4.3 50 4.1 0.5 4.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Cas_Cas02710 PF09670.10 EDK39393.2 - 3.1 6.5 5.4 0.89 8.3 0.1 2.3 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) Nop10p PF04135.12 EDK39394.1 - 1.1e-21 76.6 0.5 1.2e-21 76.4 0.5 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family RRM_1 PF00076.22 EDK39395.2 - 3.6e-18 65.1 0.0 6.7e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK39395.2 - 0.00039 20.4 0.1 0.00071 19.5 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EDK39395.2 - 0.0016 18.0 0.3 0.0027 17.3 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDK39395.2 - 0.0077 16.3 0.2 0.064 13.3 0.0 2.2 2 0 0 2 2 2 1 Limkain b1 RRM_7 PF16367.5 EDK39395.2 - 0.11 12.6 0.1 0.31 11.2 0.1 1.8 1 1 0 1 1 1 0 RNA recognition motif CENP-B_dimeris PF09026.10 EDK39395.2 - 1.2 9.6 7.0 2.2 8.7 7.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cyt-b5 PF00173.28 EDK39396.1 - 4e-24 84.5 0.3 5e-24 84.2 0.3 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NMO PF03060.15 EDK39397.2 - 5.9e-46 157.4 0.0 8e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDK39397.2 - 7.4e-06 25.2 0.0 0.054 12.5 0.0 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EDK39397.2 - 0.0029 16.7 0.0 0.0067 15.5 0.0 1.7 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Aldolase PF01081.19 EDK39397.2 - 0.017 14.6 0.1 0.059 12.8 0.0 1.9 2 0 0 2 2 2 0 KDPG and KHG aldolase Cys_Met_Meta_PP PF01053.20 EDK39398.1 - 3.6e-62 210.1 0.0 1.4e-61 208.1 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDK39398.1 - 2.3e-05 23.6 0.0 3.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDK39398.1 - 0.0065 15.7 0.0 0.009 15.2 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II MFS_1 PF07690.16 EDK39399.1 - 1.5e-20 73.4 29.6 2.2e-19 69.6 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK39399.1 - 1.4e-16 60.5 22.6 2.4e-16 59.6 22.6 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter Tmemb_14 PF03647.13 EDK39399.1 - 6.2 7.6 17.8 5.3 7.8 1.8 3.9 4 0 0 4 4 4 0 Transmembrane proteins 14C Methyltransf_PK PF05891.12 EDK39401.2 - 1.1e-78 263.8 0.0 1.2e-78 263.6 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EDK39401.2 - 0.059 14.1 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Sld5 PF05916.11 EDK39402.2 - 4.4e-23 81.8 0.2 6.1e-23 81.4 0.2 1.2 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.17 EDK39403.2 - 8.5e-26 88.0 6.0 0.0059 16.6 0.0 11.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDK39403.2 - 1.4e-22 78.5 8.6 0.0098 15.7 0.0 11.3 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDK39403.2 - 7.7e-17 61.4 8.9 0.044 14.1 0.0 10.5 9 3 3 12 12 11 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK39403.2 - 1.9e-16 58.8 25.8 0.26 11.6 0.1 12.9 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDK39403.2 - 2.3e-14 53.7 11.7 0.00015 22.2 0.0 10.5 10 2 2 12 12 11 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDK39403.2 - 3.8e-13 49.1 0.0 0.88 10.6 0.0 10.0 9 2 4 13 13 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK39403.2 - 5.1e-12 46.2 0.0 0.0002 22.0 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDK39403.2 - 7.1e-11 41.6 11.8 0.2 11.4 0.0 8.6 8 2 2 10 10 10 4 TPR repeat ANAPC3 PF12895.7 EDK39403.2 - 8.2e-07 29.2 7.3 0.044 14.0 0.0 6.1 5 1 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDK39403.2 - 9.1e-07 29.1 10.8 1.9 9.3 0.0 10.8 13 0 0 13 13 12 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDK39403.2 - 1.2e-06 28.4 8.8 0.39 11.2 0.0 8.9 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDK39403.2 - 8.2e-05 22.4 1.9 2.6 8.3 0.0 7.3 9 0 0 9 9 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDK39403.2 - 0.038 13.9 12.8 12 5.9 0.0 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat RHH_7 PF16777.5 EDK39403.2 - 0.078 13.4 0.1 0.078 13.4 0.1 4.1 4 0 0 4 4 3 0 Transcriptional regulator, RHH-like, CopG V_ATPase_I PF01496.19 EDK39403.2 - 0.86 7.4 12.6 1.8 6.4 12.6 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2225 PF09986.9 EDK39403.2 - 1 9.0 9.3 3.5 7.3 0.1 3.7 3 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF4192 PF13830.6 EDK39403.2 - 1.8 8.6 4.2 59 3.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) Spc7 PF08317.11 EDK39404.2 - 1.1e-64 218.3 5.6 1.1e-64 218.3 5.6 1.6 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 EDK39404.2 - 3e-11 43.2 0.2 8.4e-11 41.8 0.0 1.9 2 0 0 2 2 2 1 Spc7_C2 Spc7_N PF15402.6 EDK39404.2 - 1e-06 27.4 26.4 6.4e-05 21.4 19.9 2.1 1 1 1 2 2 2 2 N-terminus of kinetochore NMS complex subunit Spc7 ADIP PF11559.8 EDK39404.2 - 0.0043 17.1 3.2 1.9 8.6 0.3 2.6 2 0 0 2 2 2 2 Afadin- and alpha -actinin-Binding FAM91_C PF14648.6 EDK39404.2 - 0.0045 15.9 1.0 0.013 14.4 0.9 1.8 2 0 0 2 2 2 1 FAM91 C-terminus Med9 PF07544.13 EDK39404.2 - 0.095 12.8 1.3 0.34 11.0 0.2 2.6 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Sec2p PF06428.11 EDK39404.2 - 0.52 10.3 7.0 0.42 10.6 1.4 2.9 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p HR1 PF02185.16 EDK39404.2 - 4.3 7.5 7.7 20 5.4 0.0 3.5 2 1 1 3 3 3 0 Hr1 repeat PEX11 PF05648.14 EDK39405.1 - 3.6e-71 239.2 0.3 4.1e-71 239.0 0.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) CFEM PF05730.11 EDK39407.2 - 0.001 19.1 5.5 0.0017 18.4 5.5 1.5 1 0 0 1 1 1 1 CFEM domain ALG3 PF05208.13 EDK39408.2 - 3.8e-124 414.7 27.9 4.5e-124 414.5 27.9 1.0 1 0 0 1 1 1 1 ALG3 protein LisH PF08513.11 EDK39409.2 - 5.5e-07 29.3 0.0 9.5e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 LisH WD40 PF00400.32 EDK39410.2 - 3.4e-20 72.0 5.0 0.00051 20.8 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39410.2 - 4.7e-08 33.2 0.0 0.0008 19.7 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK39410.2 - 0.00026 19.8 0.0 0.04 12.6 0.0 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDK39410.2 - 0.0018 17.7 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 EDK39410.2 - 0.0049 15.9 0.4 1.1 8.1 0.0 2.5 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK39410.2 - 0.018 15.0 0.2 0.5 10.2 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Voltage_CLC PF00654.20 EDK39411.2 - 2.6e-70 237.4 21.9 6e-70 236.3 21.5 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EDK39411.2 - 0.014 15.9 2.4 0.32 11.5 0.1 3.4 3 0 0 3 3 3 0 CBS domain AAR2 PF05282.11 EDK39412.2 - 2e-67 228.1 2.7 2.3e-67 227.9 2.7 1.0 1 0 0 1 1 1 1 AAR2 protein Protamine_like PF06382.11 EDK39413.2 - 0.013 15.7 0.9 0.021 15.0 0.9 1.4 1 1 0 1 1 1 0 Protamine and protamine like HMG_box_2 PF09011.10 EDK39413.2 - 0.038 14.6 0.1 0.038 14.6 0.1 2.1 2 0 0 2 2 2 0 HMG-box domain Ntox34 PF15606.6 EDK39413.2 - 0.044 13.9 0.2 0.088 12.9 0.2 1.5 1 0 0 1 1 1 0 Bacterial toxin 34 HMG_box PF00505.19 EDK39413.2 - 0.076 13.4 0.2 0.076 13.4 0.2 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box DUF702 PF05142.12 EDK39413.2 - 1.3 9.5 4.8 7.6 7.0 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Arrestin_C PF02752.22 EDK39414.2 - 6.2e-10 39.7 0.0 6.2e-10 39.7 0.0 2.9 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDK39414.2 - 0.00011 22.3 0.0 0.02 14.9 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain NAD_binding_2 PF03446.15 EDK39415.2 - 3.2e-39 134.6 0.0 4.7e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EDK39415.2 - 3e-15 56.6 0.0 5.4e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase BPL_LplA_LipB PF03099.19 EDK39416.2 - 9.7e-05 22.3 0.1 0.00037 20.4 0.1 1.9 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family UPF0086 PF01868.16 EDK39417.2 - 2.6e-21 75.3 0.0 6.8e-21 74.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function UPF0086 HeLo PF14479.6 EDK39417.2 - 0.09 12.6 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation Vps51 PF08700.11 EDK39418.2 - 4.6e-07 29.8 2.0 2.1e-06 27.7 2.0 2.2 1 1 0 1 1 1 1 Vps51/Vps67 Cactin_mid PF10312.9 EDK39418.2 - 0.035 13.8 4.0 1.3 8.7 1.6 2.5 2 1 0 2 2 2 0 Conserved mid region of cactin rRNA_processing PF08524.11 EDK39418.2 - 0.41 10.7 6.5 0.39 10.7 2.0 2.2 1 1 1 2 2 2 0 rRNA processing DUF4698 PF15769.5 EDK39418.2 - 2.7 6.9 10.1 3.7 6.5 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) PUF PF00806.19 EDK39419.2 - 1.8e-56 184.8 7.8 1.5e-07 30.7 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Fungal_trans_2 PF11951.8 EDK39420.2 - 2.7e-15 56.1 1.2 1e-14 54.2 0.3 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39420.2 - 9.9e-07 28.8 12.5 2e-06 27.8 12.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ERG4_ERG24 PF01222.17 EDK39421.2 - 3e-161 537.0 26.5 3.3e-161 536.8 26.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Proteasome PF00227.26 EDK39422.1 - 5.5e-36 123.9 0.0 6.2e-36 123.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Hist_deacetyl PF00850.19 EDK39423.2 - 1e-82 278.1 0.0 1.3e-82 277.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase PF00069.25 EDK39424.2 - 5e-60 203.1 1.1 6.7e-60 202.7 1.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39424.2 - 2.3e-34 118.9 0.1 3.8e-34 118.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK39424.2 - 5.1e-06 25.5 0.0 1.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDK39424.2 - 0.00019 20.8 0.0 0.00034 20.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDK39424.2 - 0.05 13.2 0.4 0.094 12.3 0.4 1.4 1 0 0 1 1 1 0 RIO1 family Rhodanese PF00581.20 EDK39425.2 - 2.3e-11 44.1 0.0 4.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain adh_short PF00106.25 EDK39426.2 - 3.2e-89 297.6 8.6 2.3e-47 161.0 1.3 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39426.2 - 5.9e-72 242.0 8.9 8.7e-40 136.7 2.4 3.3 2 2 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EDK39426.2 - 4.5e-35 119.9 0.0 1.3e-34 118.4 0.0 1.8 1 1 0 1 1 1 1 MaoC like domain KR PF08659.10 EDK39426.2 - 1.8e-33 115.9 5.2 1.4e-17 64.2 0.8 2.3 2 0 0 2 2 2 2 KR domain GCIP PF13324.6 EDK39426.2 - 0.0046 16.6 1.6 0.0082 15.8 1.6 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting CENP-B_dimeris PF09026.10 EDK39426.2 - 0.14 12.6 8.2 0.3 11.5 8.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PglL_A PF15864.5 EDK39426.2 - 0.31 10.8 4.6 5.5 6.8 0.3 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase Epimerase PF01370.21 EDK39426.2 - 0.43 10.0 2.1 10 5.5 0.1 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RNA_pol_3_Rpc31 PF11705.8 EDK39426.2 - 0.82 9.9 8.2 1.6 8.9 8.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PBP1_TM PF14812.6 EDK39426.2 - 2.7 8.4 6.7 5.4 7.5 6.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Acyltransferase PF01553.21 EDK39427.2 - 4.7e-09 36.0 0.0 7.9e-08 32.0 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase SPT6_acidic PF14632.6 EDK39427.2 - 0.091 13.4 5.3 0.2 12.2 5.3 1.5 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DNA_ligase_A_M PF01068.21 EDK39428.1 - 1.1e-64 217.9 0.4 1.8e-64 217.2 0.4 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EDK39428.1 - 4e-46 157.5 0.2 8.8e-46 156.4 0.1 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EDK39428.1 - 9.1e-26 90.3 0.0 2e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 EDK39428.1 - 0.037 14.1 0.5 9.6 6.3 0.1 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain EFG_II PF14492.6 EDK39428.1 - 0.084 13.0 0.0 0.28 11.3 0.0 1.9 1 0 0 1 1 1 0 Elongation Factor G, domain II Histone PF00125.24 EDK39428.1 - 1.3 9.4 5.0 0.27 11.6 1.0 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Actin PF00022.19 EDK39429.2 - 1.3e-18 66.8 0.0 2.2e-17 62.8 0.0 2.0 1 1 0 1 1 1 1 Actin Aa_trans PF01490.18 EDK39430.2 - 0.078 11.7 1.1 0.11 11.2 1.1 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein Histone PF00125.24 EDK39431.2 - 1.3e-41 142.0 0.3 1.6e-41 141.7 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDK39431.2 - 8.7e-05 22.8 0.0 0.00013 22.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDK39431.2 - 0.00018 21.6 0.1 0.00026 21.0 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EDK39431.2 - 0.0015 18.8 1.0 0.0045 17.2 0.4 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDK39431.2 - 0.044 13.9 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF1358 PF07096.11 EDK39432.2 - 0.035 14.1 0.8 0.049 13.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1358) 2OG-FeII_Oxy_2 PF13532.6 EDK39433.2 - 3.9e-27 95.7 0.1 6.5e-27 95.0 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 EDK39433.2 - 0.0019 18.3 6.8 0.0036 17.4 6.8 1.5 1 0 0 1 1 1 1 GRF zinc finger CUE PF02845.16 EDK39433.2 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 CUE domain UBA2_C PF16195.5 EDK39434.1 - 0.12 13.0 3.7 0.17 12.6 3.7 1.3 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus DUF4446 PF14584.6 EDK39435.2 - 0.15 12.0 0.3 0.22 11.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TarH PF02203.15 EDK39435.2 - 0.19 11.6 0.1 0.35 10.8 0.1 1.4 1 0 0 1 1 1 0 Tar ligand binding domain homologue Alg6_Alg8 PF03155.15 EDK39436.2 - 3.3e-70 237.4 23.7 4e-70 237.1 23.7 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Alg6_Alg8 PF03155.15 EDK39437.2 - 3.6e-42 145.0 0.0 4.5e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family GCR1_C PF12550.8 EDK39438.2 - 1.4e-08 34.9 1.2 2.3e-08 34.2 0.2 1.9 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes Rad4 PF03835.15 EDK39439.2 - 1.4e-09 37.8 0.2 2.7e-09 36.8 0.2 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EDK39439.2 - 3.5e-07 30.7 0.0 7.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Zn_Tnp_IS1595 PF12760.7 EDK39439.2 - 0.26 11.3 2.8 0.88 9.6 2.4 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain PIG-Y PF15159.6 EDK39440.2 - 3.5e-09 37.5 14.1 5.9e-09 36.7 14.1 1.4 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y TMEMspv1-c74-12 PF11044.8 EDK39440.2 - 0.3 11.1 0.1 0.3 11.1 0.1 2.3 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein tRNA-synt_1b PF00579.25 EDK39441.2 - 6.9e-72 242.2 0.0 1.1e-71 241.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EDK39441.2 - 0.00071 19.4 0.1 0.0032 17.2 0.1 2.0 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain RcsD_ABL PF16359.5 EDK39441.2 - 0.11 12.6 0.0 0.33 11.1 0.1 1.7 2 0 0 2 2 2 0 RcsD-ABL domain HA2 PF04408.23 EDK39442.2 - 1e-18 67.6 0.9 2.6e-18 66.3 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK39442.2 - 3.6e-14 53.0 0.1 2.8e-13 50.2 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDK39442.2 - 7.5e-11 42.2 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDK39442.2 - 2.9e-08 33.7 0.2 6.5e-08 32.5 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK39442.2 - 1.3e-06 28.8 0.1 3.7e-06 27.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDK39442.2 - 0.0067 16.2 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EDK39442.2 - 0.015 15.0 0.0 0.044 13.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDK39442.2 - 0.026 14.4 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 EDK39442.2 - 0.032 14.6 0.0 0.13 12.6 0.1 1.9 2 0 0 2 2 2 0 AAA domain SurA_N_3 PF13624.6 EDK39442.2 - 0.062 13.1 0.7 0.46 10.3 0.3 2.3 2 0 0 2 2 2 0 SurA N-terminal domain FtsK_SpoIIIE PF01580.18 EDK39442.2 - 0.074 12.4 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EDK39442.2 - 0.1 13.1 0.1 0.1 13.1 0.1 3.4 2 1 2 4 4 4 0 ABC transporter Inositol_P PF00459.25 EDK39443.2 - 4.7e-57 193.6 0.9 1.9e-56 191.6 0.9 1.7 1 1 0 1 1 1 1 Inositol monophosphatase family DUF3985 PF13153.6 EDK39443.2 - 0.043 13.8 0.8 0.081 13.0 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3985) SUR7 PF06687.12 EDK39444.2 - 7.1e-39 133.6 5.4 9.2e-39 133.3 5.4 1.1 1 0 0 1 1 1 1 SUR7/PalI family LRR19-TM PF15176.6 EDK39444.2 - 0.056 13.4 0.0 4.6 7.3 0.0 2.6 2 1 0 2 2 2 0 Leucine-rich repeat family 19 TM domain TarH PF02203.15 EDK39444.2 - 0.23 11.4 0.0 0.53 10.2 0.0 1.6 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF2207 PF09972.9 EDK39444.2 - 4.3 6.0 4.6 16 4.1 4.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) AEP1 PF17049.5 EDK39445.2 - 0.00085 18.5 3.6 0.0017 17.5 3.3 1.5 1 1 0 1 1 1 1 ATPase expression protein 1 Tht1 PF04163.12 EDK39446.2 - 1.5e-22 80.1 14.5 2.7e-22 79.2 14.4 1.4 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Fib_alpha PF08702.10 EDK39446.2 - 0.059 13.6 0.4 0.059 13.6 0.4 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HTH_Crp_2 PF13545.6 EDK39446.2 - 0.08 12.9 0.7 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Laminin_II PF06009.12 EDK39446.2 - 0.13 12.3 2.7 0.47 10.5 1.1 2.7 1 1 0 2 2 2 0 Laminin Domain II DUF4795 PF16043.5 EDK39446.2 - 2.3 7.8 9.5 0.75 9.4 6.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Lipase_3 PF01764.25 EDK39448.2 - 3.5e-28 98.2 0.0 4.9e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 EDK39448.2 - 0.0014 18.3 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EDK39448.2 - 0.0026 17.1 0.0 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK39448.2 - 0.0063 17.1 0.0 0.017 15.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EDK39448.2 - 0.014 15.6 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.13 EDK39448.2 - 0.017 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.13 EDK39448.2 - 0.091 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1057 PF06342.12 EDK39448.2 - 0.13 11.2 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) BRCT PF00533.26 EDK39449.2 - 2.3e-06 27.9 0.0 0.099 13.0 0.0 2.8 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ribosomal_L1 PF00687.21 EDK39450.2 - 6.4e-47 159.9 1.5 6.4e-47 159.9 1.5 1.9 2 1 0 2 2 2 1 Ribosomal protein L1p/L10e family Calcipressin PF04847.12 EDK39451.2 - 5.1e-15 55.7 0.1 9.2e-15 54.9 0.1 1.4 1 1 0 1 1 1 1 Calcipressin RabGAP-TBC PF00566.18 EDK39452.2 - 7.2e-37 127.1 11.8 3.3e-33 115.2 4.7 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Metallophos PF00149.28 EDK39453.2 - 1.2e-10 42.2 7.3 3.1e-10 40.9 7.3 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDK39453.2 - 0.00019 21.7 0.0 0.00061 20.0 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain FBPase_2 PF06874.11 EDK39453.2 - 0.001 17.5 0.5 0.018 13.4 0.3 2.0 1 1 1 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Rap1-DNA-bind PF09197.10 EDK39454.2 - 1.3e-39 135.1 1.7 2.3e-36 124.7 0.0 2.9 3 0 0 3 3 3 2 Rap1, DNA-binding Rap1_C PF11626.8 EDK39454.2 - 9.1e-20 70.6 0.0 3.3e-19 68.8 0.0 2.0 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.5 EDK39454.2 - 8.5e-12 45.3 0.0 3.4e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 EDK39454.2 - 1.2e-05 25.4 2.3 0.097 12.9 0.0 3.2 3 0 0 3 3 3 2 Rap1 Myb domain Myb_DNA-binding PF00249.31 EDK39454.2 - 0.0011 19.1 0.1 0.19 11.9 0.0 3.2 2 1 0 2 2 2 1 Myb-like DNA-binding domain Glyco_hydro_17 PF00332.18 EDK39455.1 - 1.9e-09 37.5 1.6 4.3e-09 36.4 0.2 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 USP7_C2 PF14533.6 EDK39456.2 - 2.8e-56 190.5 2.0 1.8e-53 181.3 0.3 3.5 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EDK39456.2 - 6.1e-46 157.0 9.7 6e-45 153.7 1.2 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 EDK39456.2 - 3.9e-39 134.4 5.1 8.3e-39 133.3 4.3 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 EDK39456.2 - 7.1e-24 85.0 0.4 2.5e-22 79.9 0.0 3.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EDK39456.2 - 4.4e-08 33.3 4.7 5.2e-08 33.0 0.1 3.5 4 0 0 4 4 4 1 MATH domain Retinal PF15449.6 EDK39456.2 - 0.38 8.5 2.4 0.53 8.0 2.4 1.1 1 0 0 1 1 1 0 Retinal protein CTP_transf_like PF01467.26 EDK39457.2 - 1.7e-09 38.0 0.0 3.3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like COG2 PF06148.11 EDK39457.2 - 0.00081 19.5 0.2 0.0072 16.4 0.0 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 PPR_2 PF13041.6 EDK39458.2 - 8.2e-15 54.7 0.0 2.1e-12 47.0 0.0 3.2 3 0 0 3 3 3 2 PPR repeat family DUF1542 PF07564.11 EDK39458.2 - 0.072 13.2 0.8 0.22 11.7 0.8 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF148 PF02520.17 EDK39458.2 - 0.17 12.0 0.4 0.47 10.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF148 MA3 PF02847.17 EDK39459.2 - 2.3e-18 66.2 1.2 2.6e-17 62.8 0.1 2.7 3 0 0 3 3 3 1 MA3 domain Bac_DnaA_C PF08299.11 EDK39459.2 - 0.055 13.5 0.2 0.28 11.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix Cytochrom_C PF00034.21 EDK39460.1 - 7.6e-11 43.0 0.0 1.1e-10 42.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDK39460.1 - 3.9e-07 30.3 0.8 3.5e-06 27.2 0.8 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDK39460.1 - 0.025 14.3 0.3 0.3 10.8 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c-550 domain DUF3365 PF11845.8 EDK39460.1 - 0.055 13.8 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Phosducin PF02114.16 EDK39461.2 - 3.5e-18 65.5 0.2 4.2e-18 65.3 0.2 1.1 1 0 0 1 1 1 1 Phosducin rRNA_processing PF08524.11 EDK39461.2 - 0.0096 16.0 2.8 0.017 15.2 2.8 1.4 1 0 0 1 1 1 1 rRNA processing UCH PF00443.29 EDK39462.2 - 3.3e-53 180.8 6.4 4.7e-53 180.3 6.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK39462.2 - 2.6e-16 60.1 13.3 2.6e-16 60.1 13.3 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDK39462.2 - 8.9e-15 54.8 13.7 8.9e-15 54.8 13.7 3.0 2 1 1 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein Zn-ribbon_8 PF09723.10 EDK39462.2 - 4.6 7.4 8.8 15 5.8 0.1 3.9 5 0 0 5 5 5 0 Zinc ribbon domain ABC_tran PF00005.27 EDK39463.2 - 4.8e-09 36.9 0.0 7.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDK39463.2 - 0.00049 19.6 0.1 0.00063 19.2 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK39463.2 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 EDK39464.2 - 6.5e-57 193.3 33.8 6.8e-37 127.6 15.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK39464.2 - 1.3e-13 51.7 0.0 1.7e-12 48.0 0.0 2.7 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EDK39464.2 - 0.0034 17.1 1.7 0.0036 17.0 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EDK39464.2 - 0.0057 16.1 0.7 0.85 9.0 0.7 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Vps51 PF08700.11 EDK39464.2 - 0.03 14.4 1.3 0.13 12.4 0.1 2.5 2 0 0 2 2 2 0 Vps51/Vps67 AAA_18 PF13238.6 EDK39464.2 - 0.051 14.1 0.1 0.35 11.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDK39464.2 - 0.085 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 EDK39464.2 - 0.11 11.5 0.2 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.6 EDK39464.2 - 0.32 11.5 4.8 0.45 11.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain PI31_Prot_C PF08577.11 EDK39465.2 - 6e-11 43.4 10.6 1.4e-10 42.2 10.6 1.6 1 0 0 1 1 1 1 PI31 proteasome regulator Glucosamine_iso PF01182.20 EDK39466.1 - 7.3e-56 189.6 0.0 9.9e-56 189.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase WD40 PF00400.32 EDK39467.2 - 6.4e-38 128.1 12.0 8.8e-07 29.5 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EDK39467.2 - 1.6e-08 33.8 1.4 0.012 14.3 0.1 4.4 1 1 3 4 4 4 3 Nup133 N terminal like ANAPC4_WD40 PF12894.7 EDK39467.2 - 8.1e-07 29.3 0.1 0.0092 16.3 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDK39467.2 - 0.00043 19.7 0.0 0.0065 15.8 0.0 2.1 2 0 0 2 2 2 1 WD40-like domain DUF4632 PF15451.6 EDK39467.2 - 0.26 11.4 1.0 0.53 10.4 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) SBBP PF06739.11 EDK39467.2 - 0.27 11.3 0.2 0.27 11.3 0.2 2.7 3 0 0 3 3 3 0 Beta-propeller repeat MOZ_SAS PF01853.18 EDK39468.2 - 1.1e-80 269.5 0.1 2e-80 268.7 0.1 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EDK39468.2 - 1.2e-21 76.0 0.3 2.9e-21 74.8 0.3 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EDK39468.2 - 2.3e-21 75.4 0.5 4.7e-21 74.4 0.5 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EDK39468.2 - 0.0022 18.4 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PTPA PF03095.15 EDK39469.2 - 2.5e-114 381.8 0.5 3e-114 381.5 0.5 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pro_sub2 PF18513.1 EDK39469.2 - 0.0079 16.3 0.1 1.7 8.9 0.1 2.6 2 0 0 2 2 2 2 Prodomain subtilisin 2 RecG_N PF17190.4 EDK39469.2 - 0.45 11.3 2.6 2.4 9.0 0.3 2.9 3 1 0 3 3 3 0 RecG N-terminal helical domain LETM1 PF07766.13 EDK39470.2 - 0.0033 16.8 5.3 0.063 12.6 1.1 3.0 2 1 1 3 3 3 3 LETM1-like protein CLP1_P PF16575.5 EDK39471.2 - 1.9e-34 119.1 0.0 3.1e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EDK39471.2 - 8.5e-27 93.2 0.0 1.5e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EDK39471.2 - 4.1e-26 91.7 0.0 3.5e-25 88.7 0.0 2.2 2 0 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 AAA_16 PF13191.6 EDK39471.2 - 0.049 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 EDK39471.2 - 0.059 13.1 0.2 0.56 9.9 0.2 2.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein LRR_8 PF13855.6 EDK39473.2 - 4.4e-22 77.6 43.2 0.00016 21.4 5.1 9.1 5 3 5 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 EDK39473.2 - 1.1e-16 60.7 54.2 0.00036 20.9 3.4 9.6 5 4 5 11 11 11 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDK39473.2 - 4.9e-11 41.8 32.7 0.33 11.1 0.1 13.0 13 1 0 13 13 13 5 Leucine Rich repeat LRR_9 PF14580.6 EDK39473.2 - 9.8e-06 25.2 10.5 0.078 12.5 0.4 5.1 1 1 5 6 6 6 4 Leucine-rich repeat LRR_5 PF13306.6 EDK39473.2 - 3.1e-05 24.0 2.7 0.012 15.5 0.2 3.5 3 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EDK39473.2 - 3.2e-05 23.9 40.1 19 6.3 0.0 12.2 10 2 0 10 10 10 2 Leucine Rich Repeat FNIP PF05725.12 EDK39473.2 - 0.077 13.2 26.4 0.064 13.4 1.6 7.1 5 2 1 6 6 6 0 FNIP Repeat NIF PF03031.18 EDK39474.2 - 2.4e-52 176.8 0.1 3.5e-52 176.3 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MAP65_ASE1 PF03999.12 EDK39474.2 - 7.8 5.1 12.8 10 4.7 12.8 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Sof1 PF04158.14 EDK39475.2 - 6.7e-33 112.8 9.6 1.4e-32 111.8 9.6 1.6 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 EDK39475.2 - 4.3e-28 97.0 12.2 5.6e-05 23.8 0.0 6.9 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39475.2 - 0.00028 21.1 1.3 1.5 9.2 0.2 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK39475.2 - 0.0042 17.0 1.7 0.023 14.6 1.2 2.2 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EDK39475.2 - 0.011 15.1 0.5 15 4.8 0.1 3.1 3 0 0 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 EDK39475.2 - 0.018 14.0 0.6 1.1 8.2 0.0 3.3 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase PF00069.25 EDK39476.2 - 5.8e-49 166.8 0.0 1.2e-44 152.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39476.2 - 5.6e-18 65.2 0.0 1.2e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDK39476.2 - 0.051 13.5 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK39476.2 - 0.063 12.6 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Kinase-like rRNA_processing PF08524.11 EDK39476.2 - 0.27 11.2 11.6 0.48 10.4 11.6 1.3 1 0 0 1 1 1 0 rRNA processing Ist1 PF03398.14 EDK39477.2 - 2.7e-59 199.8 0.6 4e-59 199.2 0.6 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway WD40 PF00400.32 EDK39478.2 - 6.7e-33 112.2 29.5 1.4e-07 32.0 1.5 8.5 8 1 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.8 EDK39478.2 - 3.7e-06 25.9 2.8 0.04 12.6 0.2 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDK39478.2 - 6.3e-06 26.4 0.4 4 7.8 0.1 4.2 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Rhodanese PF00581.20 EDK39479.1 - 1.9e-14 54.1 0.0 4.2e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain ThiC-associated PF13667.6 EDK39479.1 - 0.08 12.8 0.0 0.73 9.7 0.0 2.3 2 0 0 2 2 2 0 ThiC-associated domain BING4CT PF08149.11 EDK39479.1 - 0.088 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 BING4CT (NUC141) domain TruD PF01142.18 EDK39480.2 - 1.5e-73 248.0 1.3 7.1e-70 235.9 0.0 3.5 1 1 1 3 3 3 2 tRNA pseudouridine synthase D (TruD) Vfa1 PF08432.10 EDK39480.2 - 8.6 6.7 12.4 16 5.7 12.4 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Kinesin PF00225.23 EDK39482.2 - 8.1e-91 304.4 0.3 1.4e-90 303.6 0.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDK39482.2 - 1.4e-23 83.4 4.1 8.2e-23 81.0 0.0 3.0 2 1 1 3 3 3 1 Microtubule binding WaaY PF06176.11 EDK39482.2 - 0.043 13.4 0.4 0.13 11.8 0.1 1.9 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) UDPG_MGDP_dh_N PF03721.14 EDK39482.2 - 0.096 12.3 0.2 0.19 11.3 0.2 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF641 PF04859.12 EDK39482.2 - 1.7 9.0 16.2 1.5 9.1 0.5 4.4 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Pkinase PF00069.25 EDK39483.2 - 5e-77 258.8 0.0 7.2e-77 258.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39483.2 - 3.6e-38 131.3 0.0 7.1e-38 130.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EDK39483.2 - 9.9e-30 102.7 0.7 8.3e-16 58.1 0.1 2.8 3 0 0 3 3 3 2 FHA domain Yop-YscD_cpl PF16697.5 EDK39483.2 - 1.3e-09 38.2 0.0 9.5e-06 25.9 0.0 2.7 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 EDK39483.2 - 4.5e-08 32.7 0.0 1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK39483.2 - 3.5e-05 23.3 0.0 6.3e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 EDK39483.2 - 9.2e-05 22.6 0.0 1.1 9.5 0.0 3.3 3 0 0 3 3 3 2 FHA domain APH PF01636.23 EDK39483.2 - 0.00018 21.5 0.0 0.057 13.3 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EDK39483.2 - 0.039 13.5 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PNP_UDP_1 PF01048.20 EDK39484.1 - 4.6e-35 121.0 0.0 5.7e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DAGAT PF03982.13 EDK39486.2 - 1.3e-54 185.1 4.9 7.2e-26 90.8 0.1 4.1 3 1 0 3 3 3 3 Diacylglycerol acyltransferase ORC3_N PF07034.11 EDK39487.2 - 3e-32 112.0 4.1 7.4e-32 110.7 0.3 2.3 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EDK39487.2 - 8.5e-22 77.7 0.3 2e-21 76.6 0.0 1.7 2 0 0 2 2 2 1 Origin recognition complex winged helix C-terminal 7TMR-HDED PF07697.11 EDK39487.2 - 0.092 12.9 16.1 2.2e+03 -1.5 16.1 3.0 1 1 0 1 1 1 0 7TM-HD extracellular DASH_Dad3 PF08656.10 EDK39487.2 - 0.31 11.2 3.1 11 6.2 0.1 3.2 3 0 0 3 3 3 0 DASH complex subunit Dad3 Cnn_1N PF07989.11 EDK39487.2 - 7.2 6.8 11.5 0.9 9.7 6.3 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Mod_r PF07200.13 EDK39487.2 - 8 6.6 13.3 0.17 12.0 1.7 3.5 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Mannosyl_trans3 PF11051.8 EDK39489.2 - 9.9e-82 274.4 0.8 9.9e-82 274.4 0.8 1.7 2 0 0 2 2 2 1 Mannosyltransferase putative Polysacc_synt_4 PF04669.13 EDK39489.2 - 0.039 13.5 3.0 0.085 12.4 3.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis SR-25 PF10500.9 EDK39489.2 - 0.79 9.3 8.7 1.8 8.1 8.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MR_MLE_C PF13378.6 EDK39490.2 - 3.2e-41 141.3 0.0 4.2e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EDK39490.2 - 1.2e-08 35.1 0.0 2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans PF04082.18 EDK39491.2 - 1.5e-19 70.1 0.0 2.3e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39491.2 - 2.8e-06 27.4 13.1 4.7e-06 26.6 13.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHDPS PF00701.22 EDK39492.1 - 3.3e-43 147.5 0.0 3.8e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family adh_short_C2 PF13561.6 EDK39493.2 - 6.3e-61 205.9 0.0 7.6e-61 205.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK39493.2 - 1.3e-44 152.0 0.1 1.7e-44 151.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK39493.2 - 7.9e-11 42.2 0.2 1.2e-10 41.6 0.2 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EDK39493.2 - 0.094 12.0 0.2 0.33 10.3 0.1 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Bac_rhamnosid6H PF17389.2 EDK39494.1 - 6.4e-18 65.1 0.1 1.8e-17 63.6 0.1 1.6 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 EDK39494.1 - 2.1e-07 30.2 0.0 3.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Trehalase MORN PF02493.20 EDK39494.1 - 0.094 12.7 0.4 0.44 10.5 0.1 2.4 2 0 0 2 2 2 0 MORN repeat PPR_1 PF12854.7 EDK39494.1 - 0.098 12.4 0.1 2.8 7.7 0.0 2.7 3 0 0 3 3 3 0 PPR repeat Bac_rhamnosid_C PF17390.2 EDK39494.1 - 0.11 12.3 0.0 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase C-terminal domain Sugar_tr PF00083.24 EDK39496.2 - 1.5e-51 175.7 14.2 1.9e-51 175.4 14.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter AA_permease PF00324.21 EDK39497.2 - 6.8e-145 483.3 41.6 7.8e-145 483.1 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK39497.2 - 1e-36 126.7 42.7 1.4e-36 126.3 42.7 1.1 1 0 0 1 1 1 1 Amino acid permease Proteasome PF00227.26 EDK39498.2 - 2.8e-47 160.7 1.1 3.1e-47 160.5 1.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Pro_isomerase PF00160.21 EDK39499.2 - 8.7e-41 139.8 0.1 1.3e-40 139.3 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EDK39500.2 - 5.2e-17 61.4 0.0 6.9e-17 61.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK39500.2 - 9.3e-06 25.3 0.0 1.1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN PF06003.12 EDK39500.2 - 0.083 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Ribophorin_I PF04597.14 EDK39501.2 - 8.3e-116 387.8 2.8 9.5e-116 387.6 2.8 1.0 1 0 0 1 1 1 1 Ribophorin I Rotamase PF00639.21 EDK39502.2 - 5.8e-24 84.9 0.1 1.8e-23 83.3 0.1 1.7 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EDK39502.2 - 1.1e-16 61.4 0.0 1.4e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EDK39502.2 - 1.1e-09 38.2 0.3 1.8e-09 37.5 0.3 1.4 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 EDK39502.2 - 1.1e-05 26.2 0.0 1.7e-05 25.7 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain AHJR-like PF18743.1 EDK39502.2 - 0.37 10.3 1.2 2.7 7.6 0.2 2.5 2 1 0 2 2 2 0 REase_AHJR-like ADK PF00406.22 EDK39503.2 - 5.4e-46 156.4 0.0 7e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDK39503.2 - 1.7e-36 125.7 0.1 2.3e-36 125.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK39503.2 - 3.8e-10 40.4 0.0 5.3e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK39503.2 - 1.2e-08 35.2 0.0 1.8e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EDK39503.2 - 2e-05 24.4 0.5 0.14 11.8 0.0 2.2 1 1 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 EDK39503.2 - 0.0023 17.3 0.0 0.0045 16.3 0.0 1.4 1 1 0 1 1 1 1 Zeta toxin SRP54 PF00448.22 EDK39503.2 - 0.0091 15.6 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain adh_short PF00106.25 EDK39504.2 - 1.9e-46 158.0 1.2 2.4e-46 157.7 1.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39504.2 - 6.2e-33 114.3 0.6 7.4e-33 114.1 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK39504.2 - 6.9e-14 52.2 1.1 1e-13 51.6 1.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK39504.2 - 3.7e-06 26.9 2.6 4.7e-06 26.6 2.6 1.3 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK39504.2 - 0.00024 20.7 0.6 0.00082 18.9 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EDK39504.2 - 0.0016 18.7 0.1 0.0031 17.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.15 EDK39504.2 - 0.0053 15.9 0.2 0.0072 15.5 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Toprim_3 PF13362.6 EDK39504.2 - 0.028 14.8 0.7 0.059 13.7 0.3 1.7 2 0 0 2 2 2 0 Toprim domain Pkinase PF00069.25 EDK39505.2 - 3e-46 157.9 1.2 5.9e-45 153.7 1.2 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39505.2 - 1.7e-19 70.2 0.1 3.3e-18 65.9 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDK39505.2 - 0.0047 16.3 0.1 0.0079 15.6 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_13 PF11972.8 EDK39505.2 - 0.23 11.5 0.0 0.83 9.8 0.0 1.8 2 0 0 2 2 2 0 HTH DNA binding domain SUN PF03856.13 EDK39507.2 - 4.2e-94 314.6 17.7 5.9e-94 314.1 17.7 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) zf-MYND PF01753.18 EDK39507.2 - 0.16 12.1 2.1 0.38 10.9 2.1 1.6 1 0 0 1 1 1 0 MYND finger Sporozoite_P67 PF05642.11 EDK39507.2 - 0.48 8.4 10.6 0.89 7.6 10.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Kinetochor_Ybp2 PF08568.10 EDK39508.2 - 1.6e-167 558.8 16.9 2.1e-167 558.4 16.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin APG12 PF04110.13 EDK39509.2 - 3.2e-25 88.3 0.0 6.2e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EDK39509.2 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like HTH_22 PF13309.6 EDK39509.2 - 0.035 14.2 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 HTH domain TFIIE_alpha PF02002.17 EDK39510.2 - 1.3e-23 82.9 0.9 8.3e-23 80.2 0.6 2.2 2 0 0 2 2 2 1 TFIIE alpha subunit Rab_eff_C PF04698.12 EDK39510.2 - 0.00036 19.0 6.4 0.00047 18.6 6.4 1.1 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus Zn_Tnp_IS1595 PF12760.7 EDK39510.2 - 0.0046 16.9 0.2 0.011 15.7 0.2 1.6 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf_UBZ PF18439.1 EDK39510.2 - 0.0086 15.6 3.4 0.094 12.3 0.0 2.9 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger OrfB_Zn_ribbon PF07282.11 EDK39510.2 - 0.072 13.0 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 EDK39510.2 - 0.087 13.0 0.6 0.25 11.5 0.5 1.8 1 1 0 1 1 1 0 Zinc ribbon domain HTH_9 PF08221.11 EDK39510.2 - 0.1 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DZR PF12773.7 EDK39510.2 - 0.11 12.5 0.3 0.24 11.5 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF2981 PF11200.8 EDK39510.2 - 0.15 11.8 2.6 0.17 11.6 1.1 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2981) TF_Zn_Ribbon PF08271.12 EDK39510.2 - 1.4 8.5 4.7 0.24 11.0 0.3 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding Forkhead PF00250.18 EDK39511.2 - 2.1e-36 124.0 0.6 1.3e-35 121.5 0.0 2.2 1 1 1 2 2 2 1 Forkhead domain G10 PF01125.17 EDK39512.1 - 7.4e-61 204.2 7.9 8.7e-61 204.0 7.9 1.0 1 0 0 1 1 1 1 G10 protein Ribosomal_L38e PF01781.18 EDK39512.1 - 0.056 13.6 0.8 0.11 12.6 0.8 1.5 1 1 0 1 1 1 0 Ribosomal L38e protein family Cnd1 PF12717.7 EDK39513.2 - 0.0001 22.4 0.7 0.0001 22.4 0.7 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDK39513.2 - 0.0016 18.1 0.2 0.083 12.4 0.1 2.3 2 0 0 2 2 2 1 CLASP N terminal Pkinase PF00069.25 EDK39513.2 - 0.009 15.4 0.0 0.02 14.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39513.2 - 0.011 15.1 0.0 0.073 12.3 0.0 2.1 1 1 0 1 1 1 0 Protein tyrosine kinase HATPase_c PF02518.26 EDK39513.2 - 0.014 15.8 0.1 0.047 14.2 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HEAT PF02985.22 EDK39513.2 - 0.02 15.1 0.0 2.6 8.6 0.0 3.6 4 0 0 4 4 4 0 HEAT repeat Proteasom_PSMB PF10508.9 EDK39513.2 - 0.025 13.1 0.6 0.038 12.5 0.6 1.2 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit GatB_Yqey PF02637.18 EDK39513.2 - 0.15 12.0 0.9 0.36 10.7 0.9 1.7 1 0 0 1 1 1 0 GatB domain OPT PF03169.15 EDK39514.2 - 4.2e-163 544.3 46.3 4.9e-163 544.1 46.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.6 EDK39514.2 - 0.11 12.8 0.1 0.11 12.8 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) FliG_N PF14842.6 EDK39514.2 - 0.16 12.5 0.4 0.3 11.6 0.4 1.4 1 0 0 1 1 1 0 FliG N-terminal domain hnRNP_Q_AcD PF18360.1 EDK39514.2 - 0.2 11.7 0.2 0.5 10.4 0.2 1.6 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain PHB_acc_N PF07879.11 EDK39515.2 - 0.048 13.8 0.3 0.1 12.7 0.1 1.7 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain OPT PF03169.15 EDK39516.2 - 9.4e-168 559.6 45.3 1.1e-167 559.4 45.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein YtzH PF14165.6 EDK39516.2 - 0.21 12.0 0.0 0.43 11.0 0.0 1.5 1 0 0 1 1 1 0 YtzH-like protein OPT PF03169.15 EDK39517.2 - 2.8e-161 538.2 50.9 3.3e-161 538.0 50.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein T3SS_needle_F PF09392.10 EDK39517.2 - 0.13 12.5 0.1 0.29 11.3 0.1 1.6 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF4405 PF14358.6 EDK39517.2 - 8.6 7.0 10.4 13 6.4 0.2 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) CAP_C PF08603.11 EDK39518.2 - 0.069 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal Ribosomal_L13 PF00572.18 EDK39521.1 - 6.5e-13 49.0 0.1 5.3e-11 42.9 0.1 2.5 1 1 0 1 1 1 1 Ribosomal protein L13 HMGL-like PF00682.19 EDK39522.2 - 6.9e-83 278.2 0.0 9.7e-83 277.7 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EDK39522.2 - 1.3e-29 102.8 1.2 2.3e-29 101.9 1.2 1.4 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain RRM_1 PF00076.22 EDK39523.2 - 2.2e-08 33.8 0.0 4.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CD20 PF04103.15 EDK39524.2 - 0.082 13.0 9.0 0.17 11.9 1.1 3.1 1 1 1 2 2 2 0 CD20-like family OATP PF03137.20 EDK39524.2 - 0.24 9.7 1.0 3.6 5.8 0.2 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family FGF-BP1 PF06473.12 EDK39524.2 - 0.26 11.1 6.7 0.44 10.3 0.2 2.2 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Hamartin PF04388.12 EDK39524.2 - 0.33 9.6 11.6 0.38 9.4 11.6 1.0 1 0 0 1 1 1 0 Hamartin protein Serinc PF03348.15 EDK39524.2 - 0.43 9.5 12.3 0.3 10.0 3.5 2.0 1 1 1 2 2 2 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 EDK39524.2 - 3.2 6.4 4.2 17 4.0 0.2 2.1 2 0 0 2 2 2 0 Reduced folate carrier Kei1 PF08552.11 EDK39524.2 - 3.4 7.5 6.3 4.6 7.1 0.9 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 SelK_SelG PF10961.8 EDK39524.2 - 3.8 8.2 8.6 0.5 11.0 0.8 3.0 1 1 2 3 3 3 0 Selenoprotein SelK_SelG Arrestin_N PF00339.29 EDK39525.2 - 6.6e-15 55.4 0.1 2e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EDK39525.2 - 2.8e-09 37.5 3.9 4.7e-08 33.6 0.0 3.3 3 1 1 4 4 4 1 Arrestin (or S-antigen), C-terminal domain Kelch_4 PF13418.6 EDK39526.2 - 1.5e-28 98.5 13.1 6.2e-08 32.5 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EDK39526.2 - 1.8e-28 98.0 17.4 5.8e-08 32.5 0.4 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EDK39526.2 - 4.9e-26 90.5 6.2 2e-06 27.9 0.1 6.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EDK39526.2 - 8.1e-25 86.2 7.9 2.2e-06 27.8 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDK39526.2 - 5e-18 64.4 6.6 2.2e-07 30.3 0.1 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EDK39526.2 - 2e-15 56.1 8.0 4.3e-06 26.5 0.1 6.1 6 0 0 6 6 6 3 Kelch motif IFT57 PF10498.9 EDK39526.2 - 0.0024 16.9 10.5 0.0024 16.9 10.5 3.4 2 1 0 3 3 3 1 Intra-flagellar transport protein 57 PKcGMP_CC PF16808.5 EDK39526.2 - 1.9 8.4 25.4 0.15 11.9 3.7 4.5 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.12 EDK39526.2 - 9.5 6.3 51.7 0.37 10.8 12.8 5.0 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Vps53_N PF04100.12 EDK39527.2 - 1.6e-53 182.1 11.9 3e-53 181.2 11.9 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 EDK39527.2 - 1.4e-07 31.6 1.9 9.9e-06 25.6 1.9 2.9 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus Sec6 PF06046.13 EDK39527.2 - 3.7e-07 28.9 7.6 6.1e-06 24.9 0.4 2.3 2 0 0 2 2 2 2 Exocyst complex component Sec6 PRAI PF00697.22 EDK39528.2 - 4.3e-43 147.4 1.1 6.3e-39 133.8 0.3 2.1 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Cpn60_TCP1 PF00118.24 EDK39529.2 - 1.4e-149 498.9 10.6 1.6e-149 498.7 10.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 EDK39529.2 - 0.00099 19.4 0.1 0.054 13.8 0.0 2.9 3 0 0 3 3 3 1 Dinitrogenase iron-molybdenum cofactor Sec2p PF06428.11 EDK39530.2 - 7e-27 93.2 12.6 7e-27 93.2 12.6 3.3 2 1 1 3 3 3 2 GDP/GTP exchange factor Sec2p Nsp1_C PF05064.13 EDK39530.2 - 6.3 6.6 14.4 0.091 12.6 2.1 3.2 3 0 0 3 3 3 0 Nsp1-like C-terminal region FH2 PF02181.23 EDK39531.2 - 2.6e-88 296.7 13.0 2.6e-88 296.7 13.0 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EDK39531.2 - 3.3e-44 150.9 0.8 3.3e-44 150.9 0.8 4.3 5 0 0 5 5 5 2 Diaphanous FH3 Domain Drf_GBD PF06371.13 EDK39531.2 - 2.9e-38 131.3 0.6 2.9e-38 131.3 0.6 4.3 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain MMS1_N PF10433.9 EDK39532.2 - 5.7e-36 124.2 0.2 1.3e-35 123.0 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PQQ_3 PF13570.6 EDK39532.2 - 0.032 14.7 0.1 65 4.2 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain Sugar_tr PF00083.24 EDK39533.2 - 1.4e-26 93.4 7.1 1.8e-26 93.0 7.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39533.2 - 2e-16 59.9 11.9 2.5e-16 59.6 11.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 2TM PF13239.6 EDK39533.2 - 0.16 12.3 1.1 20 5.6 0.2 2.8 2 0 0 2 2 2 0 2TM domain OATP PF03137.20 EDK39533.2 - 0.75 8.0 11.0 0.051 11.9 4.0 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 EDK39534.2 - 7.2e-13 48.2 11.8 9.3e-13 47.8 11.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39534.2 - 2.6e-10 39.8 10.6 3.6e-10 39.3 10.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Yip1 PF04893.17 EDK39535.2 - 1.3e-08 34.7 0.8 1.6e-08 34.5 0.8 1.0 1 0 0 1 1 1 1 Yip1 domain PPR_2 PF13041.6 EDK39536.2 - 5.8e-07 29.6 0.5 0.0011 19.1 0.0 4.2 4 0 0 4 4 4 1 PPR repeat family PPR PF01535.20 EDK39536.2 - 4e-05 23.6 0.2 5 7.6 0.0 5.3 5 0 0 5 5 5 2 PPR repeat PPR_long PF17177.4 EDK39536.2 - 0.00014 21.4 6.9 0.12 11.8 0.2 4.2 3 1 1 4 4 4 2 Pentacotripeptide-repeat region of PRORP SesA PF17107.5 EDK39536.2 - 0.0097 16.1 0.0 0.078 13.2 0.0 2.7 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_12 PF13424.6 EDK39536.2 - 1.4 9.2 6.1 15 6.0 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat SPC22 PF04573.12 EDK39537.2 - 2.6e-57 193.0 0.3 3.2e-57 192.7 0.3 1.0 1 0 0 1 1 1 1 Signal peptidase subunit Exonuc_X-T_C PF08411.10 EDK39537.2 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Exonuclease C-terminal tRNA-synt_1e PF01406.19 EDK39538.2 - 6.9e-134 445.9 0.1 6.9e-134 445.9 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EDK39538.2 - 1.7e-07 30.4 10.4 6.8e-05 21.8 0.2 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDK39538.2 - 0.00026 19.4 0.0 0.00026 19.4 0.0 2.8 3 1 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EDK39538.2 - 0.038 12.9 4.7 0.28 10.0 0.0 2.6 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Ribosomal_L14e PF01929.17 EDK39539.1 - 2.5e-32 111.2 3.8 4.4e-32 110.4 3.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 DUF3341 PF11821.8 EDK39540.2 - 0.014 15.0 2.2 0.018 14.7 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) GTP_EFTU PF00009.27 EDK39541.2 - 4.9e-63 212.2 0.1 9.4e-63 211.3 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDK39541.2 - 3e-36 123.8 0.0 9.6e-36 122.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EDK39541.2 - 5.3e-31 106.5 0.0 1.2e-30 105.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDK39541.2 - 8.7e-23 80.2 0.0 2.1e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDK39541.2 - 1.7e-12 47.5 0.1 5e-12 46.0 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDK39541.2 - 1e-07 31.8 0.0 2.2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EDK39541.2 - 0.0061 16.6 0.2 0.016 15.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 EDK39541.2 - 0.016 15.7 0.0 0.34 11.4 0.0 2.5 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain FA_desaturase PF00487.24 EDK39542.2 - 1.4e-22 80.8 22.5 1.9e-22 80.4 22.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EDK39542.2 - 9.6e-08 32.3 0.0 1.9e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) ZapB PF06005.12 EDK39543.2 - 0.13 12.7 0.5 0.21 12.1 0.5 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Chitin_synth_2 PF03142.15 EDK39545.2 - 3.5e-280 930.1 0.9 3.5e-280 930.1 0.9 1.7 2 0 0 2 2 2 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 EDK39545.2 - 1.8e-16 60.8 0.0 1.1e-13 51.6 0.0 2.4 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EDK39545.2 - 3.9e-15 56.3 2.2 1.4e-14 54.5 2.2 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EDK39545.2 - 1.9e-05 24.2 0.1 9.7e-05 21.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDK39545.2 - 2.8e-05 24.0 0.0 0.00036 20.4 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Mon2_C PF16206.5 EDK39546.2 - 2.5e-13 49.1 0.1 2.5e-08 32.6 0.0 2.6 2 0 0 2 2 2 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 EDK39546.2 - 0.0045 16.8 1.8 0.17 11.7 0.1 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) HEAT PF02985.22 EDK39546.2 - 0.1 12.9 0.6 21 5.7 0.1 3.8 3 0 0 3 3 3 0 HEAT repeat Sec7_N PF12783.7 EDK39547.2 - 2.1e-37 128.5 3.3 5.1e-37 127.2 3.3 1.7 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EDK39547.2 - 1.1e-32 113.1 0.3 1.1e-32 113.1 0.3 2.3 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 PP2C PF00481.21 EDK39548.2 - 8e-33 114.1 0.0 6.4e-22 78.4 0.0 3.6 2 1 1 3 3 3 3 Protein phosphatase 2C PP2C_2 PF13672.6 EDK39548.2 - 0.014 15.0 0.0 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein phosphatase 2C Ribosomal_S19 PF00203.21 EDK39549.1 - 2.7e-25 88.0 0.0 3.3e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.29 EDK39550.2 - 9.2e-40 136.3 0.1 2.8e-39 134.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39550.2 - 2.4e-21 76.1 0.6 1.2e-20 73.9 0.2 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39550.2 - 2.7e-09 37.3 0.1 9e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EDK39550.2 - 0.00023 20.9 0.0 0.54 9.9 0.0 2.5 2 0 0 2 2 2 2 SWI2/SNF2 ATPase Trypan_PARP PF05887.11 EDK39550.2 - 0.15 12.0 11.7 0.046 13.7 8.7 1.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) AAA_22 PF13401.6 EDK39550.2 - 0.22 11.8 1.5 2.7 8.3 1.5 2.8 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.6 EDK39550.2 - 0.39 10.0 0.0 0.39 10.0 0.0 2.7 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit GREB1 PF15782.5 EDK39550.2 - 5.7 3.9 13.2 8.6 3.3 13.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SNF2_N PF00176.23 EDK39551.2 - 1.1e-66 225.0 0.1 2.2e-66 224.0 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK39551.2 - 1.3e-19 70.6 0.0 3.7e-19 69.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39551.2 - 4.3e-06 26.8 0.0 4.3e-06 26.8 0.0 3.6 4 1 1 5 5 5 1 Type III restriction enzyme, res subunit Suc_Fer-like PF06999.12 EDK39552.2 - 1.7e-47 161.8 0.0 2e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like KilA-N PF04383.13 EDK39553.2 - 2.1e-05 24.3 2.6 0.00011 22.0 0.0 2.8 3 1 0 3 3 3 1 KilA-N domain CSRNP_N PF16019.5 EDK39553.2 - 0.0033 17.4 5.6 0.0033 17.4 5.6 1.7 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus Bap31 PF05529.12 EDK39554.2 - 3.5e-34 117.6 1.8 4.4e-34 117.2 1.8 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EDK39554.2 - 2.5e-08 33.8 1.9 3.9e-08 33.2 1.9 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain CorA PF01544.18 EDK39555.2 - 7.8e-39 133.7 1.3 8.8e-20 71.2 0.0 3.2 2 1 1 3 3 3 3 CorA-like Mg2+ transporter protein AC_N PF16214.5 EDK39555.2 - 0.44 9.6 3.8 4.4 6.3 0.2 2.4 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Aldo_ket_red PF00248.21 EDK39556.2 - 1.9e-42 145.5 0.0 2.8e-42 144.9 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family Semialdhyde_dh PF01118.24 EDK39556.2 - 0.12 12.8 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain FCH PF00611.23 EDK39557.2 - 2.1e-11 44.0 0.5 5.9e-11 42.5 0.0 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EDK39557.2 - 1.6e-09 37.2 0.0 3.2e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK39557.2 - 1e-08 34.9 0.0 2.1e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK39557.2 - 8.6e-05 22.1 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain MCM_N PF14551.6 EDK39557.2 - 0.064 13.9 1.0 0.23 12.0 0.1 2.5 2 0 0 2 2 2 0 MCM N-terminal domain YabA PF06156.13 EDK39557.2 - 1 10.0 5.7 3.4 8.4 0.1 2.7 1 1 1 2 2 2 0 Initiation control protein YabA SBF_like PF13593.6 EDK39558.2 - 3.3e-125 417.6 18.6 3.8e-125 417.4 18.6 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Motilin_assoc PF04643.12 EDK39558.2 - 0.038 13.8 0.1 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Motilin/ghrelin-associated peptide COG6 PF06419.11 EDK39559.2 - 1.2e-152 509.4 20.3 2e-152 508.6 20.3 1.3 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DASH_Dad3 PF08656.10 EDK39559.2 - 0.013 15.6 1.5 0.094 12.8 0.2 2.9 2 0 0 2 2 2 0 DASH complex subunit Dad3 Iso_dh PF00180.20 EDK39561.2 - 3e-74 250.3 0.0 3.5e-74 250.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase COX7C PF02935.16 EDK39563.1 - 9.4e-22 77.1 7.3 1.1e-21 76.8 7.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Sec1 PF00995.23 EDK39565.2 - 2.7e-67 228.3 8.0 3.1e-67 228.1 8.0 1.0 1 0 0 1 1 1 1 Sec1 family 23S_rRNA_IVP PF05635.11 EDK39565.2 - 0.014 15.7 0.0 0.073 13.4 0.0 2.2 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein 4HBT_3 PF13622.6 EDK39566.2 - 5.3e-36 125.1 0.0 7e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDK39566.2 - 3e-12 46.5 0.0 2.2e-10 40.5 0.1 2.4 2 1 0 2 2 2 1 Acyl-CoA thioesterase AP2 PF00847.20 EDK39566.2 - 0.04 14.2 0.1 0.085 13.1 0.1 1.5 1 0 0 1 1 1 0 AP2 domain 4HBT_3 PF13622.6 EDK39567.2 - 1.7e-37 130.0 0.0 2.2e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDK39567.2 - 4.1e-12 46.1 3.4 5.8e-11 42.4 0.0 2.9 3 1 0 3 3 3 2 Acyl-CoA thioesterase MFS_1 PF07690.16 EDK39568.2 - 2.7e-36 125.3 28.2 2.7e-36 125.3 28.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 EDK39569.2 - 3e-14 53.1 0.6 5.3e-14 52.3 0.6 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK39569.2 - 0.00033 20.5 0.0 0.00057 19.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDK39569.2 - 0.00038 21.5 0.2 0.0029 18.7 0.2 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AAA_5 PF07728.14 EDK39570.2 - 6.5e-127 418.1 0.1 7.4e-22 77.8 0.0 10.2 9 1 0 10 10 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EDK39570.2 - 7e-52 174.1 0.1 6e-20 71.4 0.0 5.5 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_3 PF07726.11 EDK39570.2 - 1.1e-32 112.6 0.0 6.8e-09 35.7 0.0 8.3 8 0 0 8 8 8 5 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EDK39570.2 - 2.3e-32 111.2 3.0 5.2e-31 106.9 0.0 4.3 5 0 0 5 5 3 1 Midasin AAA lid domain AAA_7 PF12775.7 EDK39570.2 - 2.7e-28 98.7 8.3 1.1e-06 28.3 0.8 7.2 7 0 0 7 7 6 5 P-loop containing dynein motor region AAA PF00004.29 EDK39570.2 - 4.2e-28 98.4 0.6 9.1e-05 22.9 0.0 7.6 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDK39570.2 - 2.4e-26 93.1 4.0 0.0018 18.7 0.0 8.0 6 1 0 6 6 6 6 AAA ATPase domain Dynein_heavy PF03028.15 EDK39570.2 - 1.3e-24 86.5 0.0 2.9e-06 27.3 0.0 9.0 8 1 0 8 8 8 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 EDK39570.2 - 5.8e-23 81.4 0.0 0.0043 16.1 0.1 9.7 9 1 0 9 9 9 5 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 EDK39570.2 - 1.7e-20 73.4 0.3 0.0015 18.3 0.0 6.7 6 0 0 6 6 6 3 Sigma-54 interaction domain AAA_14 PF13173.6 EDK39570.2 - 1.9e-18 66.7 3.0 0.013 15.6 0.0 9.0 9 0 0 9 9 7 4 AAA domain AAA_22 PF13401.6 EDK39570.2 - 2.1e-18 66.9 0.4 0.002 18.4 0.0 7.4 6 1 0 6 6 6 4 AAA domain Sigma54_activ_2 PF14532.6 EDK39570.2 - 3.3e-18 66.1 4.1 0.0036 17.4 0.0 7.5 7 0 0 7 7 6 4 Sigma-54 interaction domain TsaE PF02367.17 EDK39570.2 - 1.3e-15 57.5 6.7 0.019 15.0 0.2 7.3 7 0 0 7 7 7 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDK39570.2 - 1.2e-14 54.5 0.0 0.13 11.9 0.1 7.1 7 1 0 7 7 7 3 AAA domain AAA_18 PF13238.6 EDK39570.2 - 3e-14 53.7 20.5 0.059 13.9 0.0 9.2 7 2 1 8 8 6 4 AAA domain RNA_helicase PF00910.22 EDK39570.2 - 1.7e-11 44.5 6.6 0.24 11.8 0.1 8.1 8 0 0 8 8 7 2 RNA helicase Rad17 PF03215.15 EDK39570.2 - 2.1e-11 44.1 6.3 0.081 12.8 0.1 6.6 6 0 0 6 6 6 3 Rad17 P-loop domain AAA_33 PF13671.6 EDK39570.2 - 5e-11 42.9 2.3 0.35 11.0 0.0 6.4 6 1 0 6 6 6 3 AAA domain T2SSE PF00437.20 EDK39570.2 - 6.7e-11 41.8 6.2 0.37 9.8 0.5 6.3 6 0 0 6 6 6 2 Type II/IV secretion system protein RuvB_N PF05496.12 EDK39570.2 - 5.8e-10 39.1 1.6 2 8.1 0.0 7.8 8 1 0 8 8 8 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EDK39570.2 - 6.7e-10 39.1 2.9 0.21 11.5 0.0 5.9 5 0 0 5 5 4 2 NACHT domain AAA_28 PF13521.6 EDK39570.2 - 1.6e-09 38.2 10.0 0.86 9.8 0.0 7.7 8 0 0 8 8 6 2 AAA domain ABC_tran PF00005.27 EDK39570.2 - 1.5e-08 35.3 24.7 0.0092 16.5 0.0 8.0 7 1 0 7 7 6 2 ABC transporter PduV-EutP PF10662.9 EDK39570.2 - 3.1e-08 33.5 3.5 0.2 11.4 0.0 5.9 6 0 0 6 6 6 2 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 EDK39570.2 - 6.7e-08 32.2 6.3 8.3 5.7 0.1 8.5 8 1 0 9 9 8 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EDK39570.2 - 1.1e-07 31.4 10.8 0.39 10.0 0.0 6.8 7 0 0 7 7 6 2 Zeta toxin RsgA_GTPase PF03193.16 EDK39570.2 - 1.3e-07 31.7 9.8 0.61 10.0 1.0 6.4 6 0 0 6 6 6 2 RsgA GTPase AAA_25 PF13481.6 EDK39570.2 - 1.5e-07 31.2 2.2 1.1 8.8 0.0 5.1 5 0 0 5 5 4 2 AAA domain AAA_24 PF13479.6 EDK39570.2 - 3.3e-07 30.2 2.7 2.2 7.9 0.0 6.2 6 0 0 6 6 6 1 AAA domain AAA_19 PF13245.6 EDK39570.2 - 6e-07 29.9 9.7 0.66 10.3 0.3 6.4 6 0 0 6 6 5 2 AAA domain DUF815 PF05673.13 EDK39570.2 - 7.1e-07 28.6 5.3 0.35 10.0 0.1 5.6 6 0 0 6 6 5 2 Protein of unknown function (DUF815) AAA_29 PF13555.6 EDK39570.2 - 1.6e-06 27.7 5.9 1.5 8.6 0.1 6.3 6 0 0 6 6 6 1 P-loop containing region of AAA domain VWA PF00092.28 EDK39570.2 - 1.8e-06 28.3 0.1 1.8e-06 28.3 0.1 2.6 3 0 0 3 3 1 1 von Willebrand factor type A domain Viral_helicase1 PF01443.18 EDK39570.2 - 4.9e-06 26.4 0.9 5.6 6.6 0.0 5.8 5 0 0 5 5 5 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EDK39570.2 - 9.9e-06 25.4 5.4 0.87 9.3 0.0 6.7 9 0 0 9 9 5 1 IstB-like ATP binding protein SRP54 PF00448.22 EDK39570.2 - 1.8e-05 24.5 6.3 0.18 11.4 0.5 5.0 5 0 0 5 5 4 1 SRP54-type protein, GTPase domain AAA_8 PF12780.7 EDK39570.2 - 2.2e-05 23.9 1.0 0.93 8.8 0.2 5.3 5 0 0 5 5 5 1 P-loop containing dynein motor region D4 Roc PF08477.13 EDK39570.2 - 2.4e-05 24.5 7.1 3.1 8.0 0.1 6.6 6 0 0 6 6 6 1 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 EDK39570.2 - 2.7e-05 24.3 4.2 0.52 10.3 0.3 5.6 5 0 0 5 5 3 1 Type III restriction enzyme, res subunit TniB PF05621.11 EDK39570.2 - 3e-05 23.5 2.4 1.5 8.2 0.0 5.3 6 0 0 6 6 5 2 Bacterial TniB protein CPT PF07931.12 EDK39570.2 - 7.9e-05 22.6 0.8 13 5.6 0.0 5.9 7 0 0 7 7 5 0 Chloramphenicol phosphotransferase-like protein Bac_DnaA PF00308.18 EDK39570.2 - 0.00016 21.6 1.4 5.4 6.8 0.1 5.0 5 0 0 5 5 5 0 Bacterial dnaA protein PhoH PF02562.16 EDK39570.2 - 0.00018 21.0 1.1 1.8 7.9 0.0 4.4 5 0 0 5 5 4 1 PhoH-like protein PIF1 PF05970.14 EDK39570.2 - 0.00028 20.2 1.8 0.59 9.2 0.0 4.7 4 0 0 4 4 4 1 PIF1-like helicase ATP-synt_ab PF00006.25 EDK39570.2 - 0.00046 19.9 0.0 6.7 6.3 0.1 4.5 5 1 0 5 5 4 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.15 EDK39570.2 - 0.0011 18.9 5.5 5.6 6.8 0.4 5.8 5 0 0 5 5 5 0 NTPase dNK PF01712.19 EDK39570.2 - 0.0014 18.5 6.0 41 3.9 0.0 6.4 6 0 0 6 6 6 0 Deoxynucleoside kinase CbiA PF01656.23 EDK39570.2 - 0.0018 18.3 2.8 1.5 8.9 0.0 5.1 5 0 0 5 5 4 1 CobQ/CobB/MinD/ParA nucleotide binding domain VWA_2 PF13519.6 EDK39570.2 - 0.0022 18.6 0.3 0.053 14.2 0.1 3.1 2 0 0 2 2 2 1 von Willebrand factor type A domain ATPase PF06745.13 EDK39570.2 - 0.006 16.0 4.7 3.1 7.1 0.0 5.4 5 0 0 5 5 5 1 KaiC MMR_HSR1 PF01926.23 EDK39570.2 - 0.0062 16.6 9.3 10 6.2 0.0 5.8 6 0 0 6 6 5 0 50S ribosome-binding GTPase PRK PF00485.18 EDK39570.2 - 0.0091 15.7 0.6 24 4.6 0.0 4.4 4 0 0 4 4 3 0 Phosphoribulokinase / Uridine kinase family FtsK_SpoIIIE PF01580.18 EDK39570.2 - 0.017 14.5 0.9 14 4.9 0.1 4.4 4 0 0 4 4 4 0 FtsK/SpoIIIE family Microtub_bd PF16796.5 EDK39570.2 - 0.05 13.5 3.3 7.7 6.4 0.0 4.9 4 0 0 4 4 4 0 Microtubule binding ATP_bind_1 PF03029.17 EDK39570.2 - 0.057 13.2 11.4 3.7 7.3 0.3 5.8 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein MobB PF03205.14 EDK39570.2 - 3.9 7.4 7.6 24 4.8 0.3 4.7 6 0 0 6 6 4 0 Molybdopterin guanine dinucleotide synthesis protein B SpoIIE PF07228.12 EDK39571.2 - 1e-07 32.1 0.0 1.6e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EDK39571.2 - 4.5e-07 29.7 0.0 7.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EDK39571.2 - 0.0001 22.1 0.5 0.39 10.3 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C EPSP_synthase PF00275.20 EDK39572.2 - 2.4e-131 438.3 0.1 3.4e-131 437.8 0.1 1.1 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHquinase_I PF01487.15 EDK39572.2 - 1.1e-55 189.5 0.0 2.3e-55 188.4 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EDK39572.2 - 2.9e-33 115.2 0.0 7e-33 114.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 EDK39572.2 - 4.2e-24 84.6 0.0 1.2e-23 83.1 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EDK39572.2 - 4.1e-10 39.3 0.0 9.1e-10 38.1 0.0 1.7 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EDK39572.2 - 1.7e-06 28.2 0.0 3.8e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_33 PF13671.6 EDK39572.2 - 0.0031 17.7 0.0 0.0071 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK39572.2 - 0.0032 18.0 0.0 0.007 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EDK39572.2 - 0.094 12.0 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_14 PF13173.6 EDK39572.2 - 0.12 12.4 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DHQ_synthase PF01761.20 EDK39573.2 - 1.6e-79 266.7 0.1 2.5e-79 266.1 0.1 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EDK39573.2 - 2.2e-08 34.1 0.0 3.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EDK39573.2 - 1.1e-06 27.7 0.1 1.4e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase PolyA_pol PF01743.20 EDK39574.2 - 1.6e-16 60.9 0.2 5.5e-16 59.1 0.1 2.0 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EDK39574.2 - 1.1e-10 41.1 0.0 3e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EDK39574.2 - 2.9e-06 27.3 0.1 5.9e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative BAR_3 PF16746.5 EDK39575.2 - 7.7e-06 25.8 5.2 0.023 14.4 0.7 3.0 2 1 0 2 2 2 2 BAR domain of APPL family ArfGap PF01412.18 EDK39576.2 - 2.3e-28 98.6 4.7 2.7e-28 98.4 0.7 2.7 1 1 2 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.29 EDK39576.2 - 7e-14 52.2 0.3 2e-13 50.8 0.3 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EDK39576.2 - 2e-05 25.0 3.8 7.3e-05 23.1 0.7 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 EDK39576.2 - 0.00076 19.7 0.1 0.002 18.4 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Glyoxalase PF00903.25 EDK39576.2 - 0.059 13.6 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Pkinase PF00069.25 EDK39577.2 - 2.6e-67 227.0 0.0 3.3e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39577.2 - 3.7e-48 164.1 0.0 5e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK39577.2 - 0.0002 20.3 0.0 0.0003 19.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EDK39577.2 - 0.034 13.2 0.5 0.37 9.8 0.5 2.3 2 1 0 2 2 2 0 Seadornavirus VP7 RIO1 PF01163.22 EDK39577.2 - 0.035 13.7 0.2 0.089 12.4 0.2 1.7 1 1 0 1 1 1 0 RIO1 family ABC1 PF03109.16 EDK39577.2 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 ABC1 family TEA PF01285.18 EDK39578.2 - 2.8e-09 36.9 0.1 8.1e-09 35.4 0.1 1.8 1 0 0 1 1 1 1 TEA/ATTS domain DUF1548 PF07579.11 EDK39578.2 - 0.05 13.9 0.1 0.19 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) XPG_N PF00752.17 EDK39579.2 - 5.1e-23 81.5 0.0 1.4e-22 80.1 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EDK39579.2 - 1.6e-22 79.6 0.0 5.9e-22 77.8 0.0 2.1 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EDK39579.2 - 5.9e-05 23.6 0.0 0.00022 21.8 0.0 2.0 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 EDK39579.2 - 0.0045 16.5 1.4 0.0056 16.2 0.0 1.8 2 0 0 2 2 2 1 XPG domain containing HHH_5 PF14520.6 EDK39579.2 - 0.026 15.1 0.4 15 6.2 0.1 3.3 3 0 0 3 3 3 0 Helix-hairpin-helix domain Pox_G5 PF04599.12 EDK39579.2 - 0.11 11.4 0.1 0.27 10.2 0.1 1.5 1 0 0 1 1 1 0 Poxvirus G5 protein HHH PF00633.23 EDK39579.2 - 0.18 11.7 0.7 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif CGI-121 PF08617.10 EDK39581.1 - 1.5e-35 122.8 0.6 1.6e-35 122.6 0.6 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 MAT1 PF06391.13 EDK39582.2 - 1.9e-61 207.5 27.2 2.4e-61 207.1 27.2 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EDK39582.2 - 9.3e-27 92.7 10.5 1.6e-26 91.9 10.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK39582.2 - 0.00029 20.6 5.1 0.00052 19.8 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK39582.2 - 0.0014 18.9 7.0 0.0025 18.1 7.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDK39582.2 - 0.0017 18.2 4.2 0.0043 16.9 4.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK39582.2 - 0.0095 15.8 7.4 0.018 14.9 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK39582.2 - 0.019 15.0 8.9 0.044 13.8 8.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Fibrillarin PF01269.17 EDK39582.2 - 0.032 13.4 3.2 0.46 9.5 2.9 2.1 2 0 0 2 2 2 0 Fibrillarin zf-piccolo PF05715.13 EDK39582.2 - 0.13 12.4 1.3 0.29 11.3 1.3 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger zf-RING_5 PF14634.6 EDK39582.2 - 0.14 12.2 9.1 2 8.4 9.5 2.3 1 1 1 2 2 2 0 zinc-RING finger domain IBR PF01485.21 EDK39582.2 - 1.2 9.4 0.1 1.2 9.4 0.1 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain DUF4559 PF15112.6 EDK39582.2 - 2.9 7.5 18.6 4 7.0 18.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Prok-RING_4 PF14447.6 EDK39582.2 - 9.7 6.2 9.9 44 4.0 0.3 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DHHC PF01529.20 EDK39583.2 - 2e-18 66.8 11.4 2e-18 66.8 11.4 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3270 PF11674.8 EDK39583.2 - 0.21 11.8 1.2 0.45 10.7 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) COX4 PF02936.14 EDK39583.2 - 0.42 10.6 2.8 0.3 11.1 0.2 1.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV DHHC PF01529.20 EDK39584.2 - 0.0014 18.8 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase RPAP1_C PF08620.10 EDK39585.2 - 1.1e-28 99.1 0.2 4.4e-28 97.2 0.0 2.0 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EDK39585.2 - 1.6e-18 66.2 2.4 3.3e-18 65.2 2.4 1.6 1 0 0 1 1 1 1 RPAP1-like, N-terminal Pmp3 PF01679.17 EDK39586.2 - 1.3e-16 60.5 9.7 1.5e-16 60.3 9.7 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 EDK39586.2 - 0.069 13.3 0.6 0.084 13.0 0.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) STE2 PF02116.15 EDK39586.2 - 0.17 11.1 0.0 0.18 11.1 0.0 1.0 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR ADH_zinc_N_2 PF13602.6 EDK39587.2 - 1.3e-15 58.6 0.0 2.8e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDK39587.2 - 6.4e-13 48.8 0.3 7.2e-12 45.4 0.0 2.5 2 1 1 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK39587.2 - 0.0035 17.2 0.7 0.017 15.0 0.1 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Pkinase PF00069.25 EDK39588.2 - 8.8e-67 225.2 0.0 1.3e-66 224.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39588.2 - 2.7e-50 171.1 0.0 4e-50 170.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EDK39588.2 - 1e-36 125.2 0.0 2e-36 124.3 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 EDK39588.2 - 3.3e-11 43.1 0.0 9.9e-11 41.6 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDK39588.2 - 8e-11 42.2 0.0 2.4e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EDK39588.2 - 2.1e-06 27.3 0.0 0.0015 17.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EDK39588.2 - 0.0061 15.4 0.5 0.011 14.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EDK39588.2 - 0.023 13.6 0.1 0.21 10.5 0.1 2.1 1 1 0 1 1 1 0 Haspin like kinase domain SAM_4 PF18017.1 EDK39588.2 - 0.063 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase PF00069.25 EDK39589.2 - 9.4e-36 123.5 0.0 2.1e-23 83.1 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39589.2 - 8.4e-18 64.6 0.0 1.1e-14 54.3 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EDK39589.2 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDK39589.2 - 0.0018 17.6 0.0 0.004 16.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDK39589.2 - 0.0021 17.7 0.2 0.017 14.7 0.1 2.4 3 0 0 3 3 3 1 RIO1 family Pkinase_fungal PF17667.1 EDK39589.2 - 0.011 14.5 0.0 0.011 14.5 0.0 2.2 3 0 0 3 3 3 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EDK39589.2 - 0.026 14.0 0.6 0.11 12.0 0.0 2.3 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EDK39589.2 - 0.059 12.3 0.1 0.059 12.3 0.1 2.9 3 0 0 3 3 3 0 Haspin like kinase domain Sp38 PF07354.12 EDK39589.2 - 0.17 11.3 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Sugar_tr PF00083.24 EDK39590.1 - 6e-117 391.3 21.1 7.1e-117 391.0 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39590.1 - 4.9e-23 81.6 38.9 8.8e-18 64.3 11.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Metallophos PF00149.28 EDK39591.2 - 3.6e-18 66.8 0.0 6.8e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CDC45 PF02724.14 EDK39591.2 - 0.54 8.5 7.5 0.97 7.7 7.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 EDK39591.2 - 0.61 9.5 4.3 1.2 8.6 4.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2052 PF09747.9 EDK39591.2 - 0.7 10.0 10.2 1.2 9.2 10.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 EDK39591.2 - 1.2 8.9 11.1 2 8.2 11.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4337 PF14235.6 EDK39591.2 - 4.4 7.4 13.3 2.6 8.1 10.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) CASP_C PF08172.12 EDK39592.2 - 4e-64 216.4 7.4 4e-64 216.4 7.4 3.9 3 1 0 3 3 3 1 CASP C terminal Lectin_N PF03954.14 EDK39592.2 - 0.0071 16.1 5.4 0.0071 16.1 5.4 5.0 4 1 1 5 5 5 2 Hepatic lectin, N-terminal domain TPR_MLP1_2 PF07926.12 EDK39592.2 - 0.018 15.1 4.8 0.018 15.1 4.8 7.5 4 2 4 8 8 8 0 TPR/MLP1/MLP2-like protein SlyX PF04102.12 EDK39592.2 - 0.41 11.3 0.0 0.41 11.3 0.0 7.2 5 3 3 8 8 8 0 SlyX DUF2935 PF11155.8 EDK39592.2 - 1.2 9.5 16.2 0.52 10.7 0.4 5.0 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) FlaC_arch PF05377.11 EDK39592.2 - 4.7 7.7 32.8 0.47 10.9 0.2 7.6 7 1 1 8 8 8 0 Flagella accessory protein C (FlaC) Ribosomal_L21e PF01157.18 EDK39593.1 - 1.1e-31 108.7 6.5 1.1e-31 108.7 6.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 EDK39593.1 - 0.00017 21.3 0.0 0.00019 21.1 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 Diphthami_syn_2 PF01902.17 EDK39595.2 - 4.2e-41 140.9 0.0 9.5e-41 139.7 0.0 1.6 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EDK39595.2 - 7.5e-14 51.8 0.1 9.4e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 Endoribonuclease L-PSP Erf4 PF10256.9 EDK39595.2 - 0.066 13.3 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family LicD PF04991.13 EDK39596.2 - 1.3e-29 104.0 15.1 7.4e-27 95.0 1.7 3.5 2 1 1 3 3 3 2 LicD family DUF4894 PF16235.5 EDK39596.2 - 0.066 13.6 0.3 0.52 10.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4894) CN_hydrolase PF00795.22 EDK39597.2 - 3e-17 62.8 0.0 2.7e-15 56.4 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase LicD PF04991.13 EDK39598.2 - 8.1e-32 111.2 2.9 1.3e-28 100.7 0.7 3.6 3 1 1 4 4 4 2 LicD family DUF4179 PF13786.6 EDK39598.2 - 0.0094 16.4 0.0 0.027 14.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4179) Sialidase PF02973.16 EDK39598.2 - 0.038 13.5 0.1 0.076 12.5 0.1 1.4 1 0 0 1 1 1 0 Sialidase, N-terminal domain COX6A PF02046.15 EDK39599.1 - 5e-43 146.1 2.4 5.9e-43 145.9 2.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.32 EDK39601.2 - 3.2e-08 34.1 0.9 0.002 18.9 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39601.2 - 0.077 13.3 0.0 43 4.5 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain hNIFK_binding PF12196.8 EDK39601.2 - 5 6.7 7.3 47 3.6 5.7 2.3 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK Ribosomal_S26e PF01283.19 EDK39602.1 - 3.6e-52 175.3 11.4 4.2e-52 175.1 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e COX5B PF01215.19 EDK39603.2 - 1.3e-50 170.4 0.1 1.5e-50 170.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 EDK39603.2 - 0.029 14.4 2.7 0.047 13.7 2.7 1.4 1 0 0 1 1 1 0 Zinc-finger domain 2-Hacid_dh_C PF02826.19 EDK39604.2 - 1.8e-40 138.2 0.0 2.4e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDK39604.2 - 1.9e-14 53.5 0.0 2.3e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EDK39604.2 - 0.0004 20.9 0.0 0.0014 19.2 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EDK39604.2 - 0.00044 20.4 0.3 0.00085 19.5 0.1 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 EDK39604.2 - 0.00083 19.2 0.4 0.0019 18.0 0.1 1.8 2 0 0 2 2 2 1 Rossmann-like domain IlvN PF07991.12 EDK39604.2 - 0.0011 18.5 0.1 0.0018 17.8 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 EDK39604.2 - 0.023 14.8 0.2 0.047 13.8 0.2 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 EDK39604.2 - 0.03 14.7 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 EDK39604.2 - 0.047 13.3 0.1 0.09 12.4 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.22 EDK39604.2 - 0.12 13.2 0.1 0.36 11.7 0.1 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Shikimate_DH PF01488.20 EDK39604.2 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SH3_1 PF00018.28 EDK39605.2 - 4.2e-36 122.3 6.9 7e-12 44.8 0.0 4.5 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EDK39605.2 - 6.2e-33 112.4 5.7 5.4e-10 39.0 0.2 4.4 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 EDK39605.2 - 4.5e-31 106.5 0.0 8.1e-31 105.7 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 EDK39605.2 - 6.3e-28 96.2 0.1 4.9e-07 29.3 0.0 4.7 4 0 0 4 4 4 4 Variant SH3 domain SAM_4 PF18017.1 EDK39605.2 - 0.00029 20.7 0.0 0.00061 19.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MazE_antitoxin PF04014.18 EDK39605.2 - 1.2 9.2 4.3 72 3.5 0.0 4.1 4 0 0 4 4 4 0 Antidote-toxin recognition MazE, bacterial antitoxin MT-A70 PF05063.14 EDK39606.2 - 4.8e-51 173.1 0.2 7.9e-51 172.4 0.2 1.4 1 0 0 1 1 1 1 MT-A70 SpoOE-like PF09388.10 EDK39606.2 - 0.072 13.0 0.2 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein DUF2309 PF10070.9 EDK39606.2 - 0.17 10.2 0.0 0.23 9.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) DUF962 PF06127.11 EDK39607.2 - 2.1e-22 79.0 2.5 5.5e-22 77.7 2.5 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF962) STT3 PF02516.14 EDK39608.2 - 4.3e-153 510.8 35.9 4.1e-149 497.6 33.5 2.2 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit TPPK_C PF12555.8 EDK39608.2 - 1.3 9.1 8.5 0.58 10.3 1.2 3.4 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal FYVE PF01363.21 EDK39609.2 - 2.1e-15 56.6 6.7 3.8e-15 55.8 6.7 1.4 1 0 0 1 1 1 1 FYVE zinc finger HNH_5 PF14279.6 EDK39609.2 - 0.033 14.0 1.9 0.08 12.8 1.9 1.7 1 0 0 1 1 1 0 HNH endonuclease FUN14 PF04930.15 EDK39610.1 - 2e-08 34.5 1.1 3.7e-08 33.7 1.1 1.5 1 0 0 1 1 1 1 FUN14 family ATPase_gene1 PF09527.10 EDK39610.1 - 6.3 7.1 9.2 12 6.1 0.1 2.9 2 1 1 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter RNA_pol_Rpb1_5 PF04998.17 EDK39611.2 - 4.1e-95 318.2 0.1 1.4e-94 316.5 0.1 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDK39611.2 - 3.9e-69 232.1 0.2 9.2e-69 230.9 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDK39611.2 - 5.3e-38 130.4 0.0 3e-37 128.0 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EDK39611.2 - 7.4e-26 91.2 0.2 7.4e-26 91.2 0.2 3.5 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EDK39611.2 - 4.1e-24 84.6 0.1 2.3e-23 82.2 0.1 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 MycE_N PF17843.1 EDK39611.2 - 0.17 12.3 0.1 38 4.8 0.0 2.7 2 0 0 2 2 2 0 MycE methyltransferase N-terminal Isy1 PF06246.12 EDK39611.2 - 2.8 7.4 16.6 10 5.6 10.2 3.1 3 0 0 3 3 3 0 Isy1-like splicing family C2 PF00168.30 EDK39612.2 - 7.4e-58 193.2 2.0 9.7e-16 57.9 0.1 4.5 4 0 0 4 4 4 4 C2 domain RNA_pol_Rpc4 PF05132.14 EDK39612.2 - 0.0012 19.2 5.2 0.0031 17.9 5.2 1.6 1 0 0 1 1 1 1 RNA polymerase III RPC4 SMP_LBD PF17047.5 EDK39612.2 - 0.019 14.4 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain NPR3 PF03666.13 EDK39612.2 - 0.058 12.2 7.1 0.097 11.5 7.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 EDK39612.2 - 0.27 11.0 4.6 0.52 10.0 4.6 1.4 1 0 0 1 1 1 0 Connexin DUF4746 PF15928.5 EDK39612.2 - 1.2 8.5 19.0 2 7.7 19.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 EDK39612.2 - 1.2 9.1 4.8 2.4 8.1 4.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 EDK39612.2 - 1.9 7.9 4.4 3.5 7.0 4.4 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Zip PF02535.22 EDK39612.2 - 2.1 7.5 7.3 3.9 6.6 7.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 EDK39612.2 - 2.5 6.8 10.4 4.5 6.0 10.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Vfa1 PF08432.10 EDK39612.2 - 2.9 8.2 17.4 7.1 6.9 17.4 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PTPRCAP PF15713.5 EDK39612.2 - 4.9 7.4 18.1 9.8 6.4 18.1 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 EDK39612.2 - 8.9 6.0 19.1 16 5.2 19.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EDK39612.2 - 9.9 4.3 13.4 15 3.8 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein LtrA PF06772.11 EDK39613.2 - 3.9e-38 131.6 16.7 5.9e-38 131.0 16.7 1.2 1 1 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF4491 PF14898.6 EDK39613.2 - 1.3 9.5 10.0 0.1 13.0 1.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) MRP-S25 PF13741.6 EDK39614.2 - 7.8e-92 307.0 0.2 1e-91 306.6 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EDK39614.2 - 8.4e-07 29.3 0.3 0.00092 19.5 0.0 2.9 1 1 2 3 3 3 2 Mitochondrial ribosomal protein S23 PPR_2 PF13041.6 EDK39615.2 - 0.013 15.6 0.0 3.1 8.1 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family DnaB_2 PF07261.11 EDK39615.2 - 0.02 14.6 0.0 3.9 7.3 0.0 3.2 4 0 0 4 4 4 0 Replication initiation and membrane attachment MarR_2 PF12802.7 EDK39615.2 - 0.041 13.8 0.0 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 MarR family ATP13 PF12921.7 EDK39615.2 - 0.061 13.2 0.2 3 7.7 0.0 3.1 3 0 0 3 3 3 0 Mitochondrial ATPase expression Omp_AT PF11557.8 EDK39616.2 - 0.0011 18.0 0.0 0.0011 18.0 0.0 1.1 1 0 0 1 1 1 1 Solitary outer membrane autotransporter beta-barrel domain Phage_holin_3_6 PF07332.11 EDK39616.2 - 0.13 12.3 0.8 0.62 10.1 0.3 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III OAD_gamma PF04277.13 EDK39616.2 - 0.44 11.2 1.8 0.96 10.1 1.7 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Frataxin_Cyay PF01491.16 EDK39617.1 - 7e-37 125.8 0.0 9e-37 125.5 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain zf-MIZ PF02891.20 EDK39618.2 - 3.8e-10 39.3 1.8 3.6e-08 33.0 0.2 2.7 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDK39618.2 - 3.9e-05 23.4 4.1 0.00058 19.6 3.5 2.8 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DUF668 PF05003.12 EDK39618.2 - 0.15 12.5 0.1 3.6 8.1 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF668) DUF21 PF01595.20 EDK39619.2 - 5.1e-32 111.0 0.0 1.4e-31 109.5 0.0 1.7 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EDK39619.2 - 0.0018 18.6 0.1 1.5 9.3 0.0 3.1 3 0 0 3 3 3 2 CBS domain UPF0239 PF06783.11 EDK39619.2 - 1.4 9.2 3.6 1.5 9.1 0.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Pkinase PF00069.25 EDK39620.2 - 1.1e-44 152.9 0.0 1.8e-44 152.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39620.2 - 2.2e-17 63.2 0.1 8.4e-17 61.3 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EDK39620.2 - 0.0013 18.4 5.9 0.43 10.2 0.0 3.3 1 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDK39620.2 - 0.025 14.5 0.1 0.14 12.1 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK39620.2 - 0.037 13.3 0.2 0.13 11.6 0.1 1.9 2 0 0 2 2 2 0 Kinase-like Solute_trans_a PF03619.16 EDK39621.2 - 7.4e-81 271.5 15.4 9.2e-81 271.2 15.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha mIF3 PF14877.6 EDK39622.2 - 5.4e-58 195.6 4.2 5.4e-58 195.6 4.2 1.8 2 0 0 2 2 2 1 Mitochondrial translation initiation factor Cue1_U7BR PF18499.1 EDK39622.2 - 0.015 15.4 0.0 0.039 14.0 0.0 1.7 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 NtA PF03146.15 EDK39622.2 - 0.22 11.4 2.5 1 9.3 0.6 2.3 1 1 1 2 2 2 0 Agrin NtA domain Fe_hyd_lg_C PF02906.14 EDK39623.2 - 2e-61 207.7 0.0 5.1e-61 206.4 0.0 1.7 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Ytp1 PF10355.9 EDK39624.2 - 4.8e-50 170.3 15.2 4e-48 164.0 15.2 2.3 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) TssN PF17555.2 EDK39624.2 - 9.6 5.5 8.1 0.27 10.6 0.3 2.3 3 0 0 3 3 3 0 Type VI secretion system, TssN Peptidase_S8 PF00082.22 EDK39625.2 - 1.1e-34 120.0 1.2 1.1e-34 120.0 1.2 1.9 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 EDK39625.2 - 2e-23 82.2 0.1 4.9e-23 81.0 0.1 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain Plasmodium_Vir PF05795.11 EDK39625.2 - 1.3e-05 24.8 1.4 2.3e-05 24.0 1.4 1.3 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF1180 PF06679.12 EDK39625.2 - 0.0053 17.2 0.1 0.011 16.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) MGC-24 PF05283.11 EDK39625.2 - 0.025 15.0 1.9 0.054 13.9 1.9 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Peptidase_S8_N PF16361.5 EDK39625.2 - 0.035 14.6 0.0 0.035 14.6 0.0 2.7 3 0 0 3 3 3 0 N-terminal of Subtilase family RIFIN PF02009.16 EDK39625.2 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Rifin TMEM154 PF15102.6 EDK39625.2 - 0.44 10.4 6.3 1.4 8.9 6.3 1.8 1 1 0 1 1 1 0 TMEM154 protein family G6PD_C PF02781.16 EDK39626.2 - 1e-110 369.5 0.0 6.3e-110 366.9 0.0 1.8 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EDK39626.2 - 5.9e-62 209.4 0.1 1.3e-61 208.3 0.1 1.6 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Paz_1 PF18349.1 EDK39626.2 - 0.043 13.8 0.2 0.13 12.3 0.2 1.8 1 0 0 1 1 1 0 PAZ domain WD40 PF00400.32 EDK39627.2 - 0.03 15.2 0.0 2.1 9.3 0.0 2.9 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF4611 PF15387.6 EDK39627.2 - 0.096 12.9 1.3 0.19 11.9 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) WD40 PF00400.32 EDK39628.2 - 2.1e-18 66.3 13.6 0.00014 22.6 0.4 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39628.2 - 6.2e-09 36.1 2.0 0.064 13.6 0.2 3.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK39628.2 - 9.3e-06 24.8 0.1 0.29 10.1 0.0 3.7 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Glycos_transf_4 PF00953.21 EDK39629.2 - 2.3e-31 108.9 16.8 2.3e-31 108.9 16.8 2.3 2 1 0 2 2 2 1 Glycosyl transferase family 4 Adipogenin PF15202.6 EDK39629.2 - 0.98 9.5 0.0 0.98 9.5 0.0 2.9 5 0 0 5 5 5 0 Adipogenin PQQ_3 PF13570.6 EDK39631.2 - 0.025 15.1 0.5 8.7 7.0 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain WD40 PF00400.32 EDK39631.2 - 0.05 14.5 16.6 7.2 7.7 0.0 5.8 6 0 0 6 6 6 0 WD domain, G-beta repeat DUF3663 PF12404.8 EDK39631.2 - 0.15 12.2 0.0 3.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Peptidase ELFV_dehydrog PF00208.21 EDK39632.2 - 8.8e-66 222.1 0.0 1.4e-65 221.4 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EDK39632.2 - 1e-20 73.0 0.0 4.8e-16 57.6 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EDK39632.2 - 0.042 13.7 0.0 0.17 11.7 0.0 2.0 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ubiquitin_3 PF14836.6 EDK39632.2 - 0.064 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Pribosyl_synth PF14572.6 EDK39633.2 - 1.5e-39 135.9 0.1 2.2e-39 135.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDK39633.2 - 6.1e-32 110.0 0.0 1.6e-31 108.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDK39633.2 - 1.1e-12 47.8 0.2 4e-12 45.9 0.2 1.9 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Adap_comp_sub PF00928.21 EDK39634.2 - 1.7e-69 234.2 0.1 2e-69 233.9 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDK39634.2 - 1.4e-05 25.1 0.0 3.2e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain muHD PF10291.9 EDK39634.2 - 0.0066 15.9 0.0 0.016 14.7 0.0 1.6 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain CUE PF02845.16 EDK39635.2 - 1.5e-09 37.4 0.1 3.8e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 CUE domain Pho86 PF11124.8 EDK39636.2 - 4.7e-108 361.1 0.1 5.4e-108 360.9 0.1 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 Lectin_leg-like PF03388.13 EDK39637.2 - 4.7e-57 193.0 0.0 5.9e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EDK39637.2 - 2e-09 37.8 0.2 2.8e-09 37.3 0.2 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EDK39637.2 - 0.0029 17.2 0.1 0.21 11.1 0.1 2.1 2 0 0 2 2 2 2 Legume lectin domain PDE8 PF08629.10 EDK39637.2 - 0.033 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 PDE8 phosphodiesterase Histone PF00125.24 EDK39637.2 - 0.044 14.1 1.6 0.073 13.4 1.6 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 His_Phos_1 PF00300.22 EDK39639.1 - 1.2e-36 126.3 0.0 1.6e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EDK39639.1 - 0.05 12.9 0.0 0.093 12.1 0.0 1.4 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) IU_nuc_hydro PF01156.19 EDK39640.2 - 4.3e-72 243.3 0.0 5.2e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF296 PF03479.15 EDK39640.2 - 0.075 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Plants and Prokaryotes Conserved (PCC) domain Abhydro_lipase PF04083.16 EDK39641.2 - 8e-16 57.4 0.0 1.3e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EDK39641.2 - 0.0038 16.5 0.0 0.051 12.8 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Mito_carr PF00153.27 EDK39642.2 - 1.2e-61 204.6 6.0 4.5e-21 74.6 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein 2-Hacid_dh_C PF02826.19 EDK39643.2 - 4.7e-50 169.4 0.0 6.4e-50 169.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDK39643.2 - 1.5e-14 53.8 0.0 3.5e-14 52.6 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDK39643.2 - 3.1e-05 24.2 0.0 8e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EDK39643.2 - 0.00034 21.1 0.0 0.00095 19.7 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EDK39643.2 - 0.00043 19.9 0.0 0.00077 19.1 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EDK39643.2 - 0.0026 17.1 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF4056 PF13265.6 EDK39643.2 - 0.066 12.5 0.1 0.51 9.6 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4056) DUF3015 PF11220.8 EDK39643.2 - 0.073 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) Peptidase_M28 PF04389.17 EDK39644.2 - 2.3e-38 131.9 0.1 3.2e-38 131.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDK39644.2 - 1.4e-09 37.8 0.4 4.5e-09 36.2 0.4 1.8 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EDK39644.2 - 5.3e-05 23.0 0.0 0.00011 21.9 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EDK39644.2 - 0.0046 16.0 0.1 0.014 14.4 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase SWC7 PF17330.2 EDK39644.2 - 0.019 15.0 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 DnaJ PF00226.31 EDK39645.2 - 4e-20 71.7 2.6 1.6e-19 69.8 2.6 2.1 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.6 EDK39645.2 - 3.6e-07 29.9 1.7 0.03 14.5 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDK39645.2 - 2.4e-05 24.1 3.1 0.29 11.4 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDK39645.2 - 0.00097 18.9 9.6 0.01 15.6 0.0 5.0 6 1 0 6 6 6 1 Tetratricopeptide repeat Pex14_N PF04695.13 EDK39645.2 - 0.46 11.1 9.4 0.46 11.1 7.6 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Activator_LAG-3 PF11498.8 EDK39645.2 - 1.9 7.3 27.3 3.2 6.6 27.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 GCK PF07802.11 EDK39645.2 - 8.1 7.0 8.2 6.8 7.2 0.6 3.3 3 0 0 3 3 3 0 GCK domain AAA PF00004.29 EDK39646.2 - 1.3e-42 145.3 0.0 2.5e-42 144.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK39646.2 - 1.5e-14 53.5 0.0 3.2e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDK39646.2 - 7.5e-07 29.2 0.0 2.3e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDK39646.2 - 1.1e-06 28.9 0.0 2.4e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 EDK39646.2 - 1e-05 25.4 0.3 2.8e-05 24.0 0.3 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EDK39646.2 - 2.9e-05 24.4 0.7 0.02 15.2 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK39646.2 - 5.9e-05 23.5 0.7 0.0006 20.2 0.0 2.6 3 1 1 4 4 2 1 AAA ATPase domain RuvB_N PF05496.12 EDK39646.2 - 0.00049 19.9 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EDK39646.2 - 0.0017 18.5 0.0 0.0035 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDK39646.2 - 0.0035 17.9 0.1 0.05 14.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain DUF2968 PF11180.8 EDK39646.2 - 0.0043 16.7 0.4 0.0078 15.9 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) IstB_IS21 PF01695.17 EDK39646.2 - 0.0056 16.4 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_13 PF13166.6 EDK39646.2 - 0.0098 14.6 0.5 0.11 11.1 0.2 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EDK39646.2 - 0.016 15.3 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDK39646.2 - 0.017 14.9 0.2 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDK39646.2 - 0.018 14.4 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Filament PF00038.21 EDK39646.2 - 0.018 14.6 0.2 0.031 13.8 0.2 1.3 1 0 0 1 1 1 0 Intermediate filament protein HrpB7 PF09486.10 EDK39646.2 - 0.02 15.3 1.4 0.039 14.3 1.4 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) TIP49 PF06068.13 EDK39646.2 - 0.025 13.8 0.0 0.053 12.7 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 EDK39646.2 - 0.025 14.4 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APG6_N PF17675.1 EDK39646.2 - 0.025 15.1 0.3 0.049 14.2 0.3 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_25 PF13481.6 EDK39646.2 - 0.03 13.9 0.0 0.074 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDK39646.2 - 0.03 13.7 0.0 0.085 12.2 0.0 1.7 1 0 0 1 1 1 0 KaiC Tropomyosin PF00261.20 EDK39646.2 - 0.03 13.7 3.3 0.038 13.4 1.1 1.9 2 0 0 2 2 2 0 Tropomyosin AAA_28 PF13521.6 EDK39646.2 - 0.031 14.5 0.3 0.079 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDK39646.2 - 0.032 13.9 0.0 0.096 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDK39646.2 - 0.032 13.7 0.0 0.12 11.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 EDK39646.2 - 0.04 14.3 0.0 0.079 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TMF_TATA_bd PF12325.8 EDK39646.2 - 0.042 14.1 0.2 0.13 12.5 0.2 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF2072 PF09845.9 EDK39646.2 - 0.043 14.1 0.2 0.084 13.1 0.2 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein TsaE PF02367.17 EDK39646.2 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE UvrD-helicase PF00580.21 EDK39646.2 - 0.061 12.8 0.2 0.16 11.5 0.1 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DivIC PF04977.15 EDK39646.2 - 0.083 12.7 0.7 0.18 11.6 0.7 1.5 1 0 0 1 1 1 0 Septum formation initiator NACHT PF05729.12 EDK39646.2 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 1 0 NACHT domain DUF4763 PF15960.5 EDK39646.2 - 0.15 11.3 2.7 0.31 10.3 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) ATG16 PF08614.11 EDK39646.2 - 0.2 11.9 4.0 0.33 11.2 4.0 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) HR1 PF02185.16 EDK39646.2 - 0.6 10.3 5.7 1.6 8.9 5.7 1.7 1 0 0 1 1 1 0 Hr1 repeat MIF4G PF02854.19 EDK39648.2 - 2.3e-39 135.2 0.6 4.1e-39 134.4 0.6 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EDK39648.2 - 3.1e-23 81.7 3.4 4.4e-23 81.2 1.1 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 DUF4820 PF16091.5 EDK39648.2 - 8.2 5.7 15.1 0.16 11.3 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) AAA PF00004.29 EDK39649.2 - 1.7e-15 57.6 0.0 4.1e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDK39649.2 - 2.7e-13 50.0 0.0 1.2e-12 47.9 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EDK39649.2 - 1.1e-06 28.8 0.0 5.5e-06 26.6 0.0 2.1 2 0 0 2 2 1 1 AAA C-terminal domain AAA_14 PF13173.6 EDK39649.2 - 3.2e-06 27.2 0.0 7.5e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK39649.2 - 2.8e-05 24.3 0.0 0.00013 22.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EDK39649.2 - 5.1e-05 23.7 0.2 0.0027 18.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK39649.2 - 0.00026 21.3 0.3 0.01 16.1 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDK39649.2 - 0.00032 20.7 0.0 0.0014 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EDK39649.2 - 0.00048 19.4 0.0 0.02 14.1 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 EDK39649.2 - 0.00077 20.0 0.0 0.0022 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDK39649.2 - 0.00093 19.6 0.0 0.0028 18.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EDK39649.2 - 0.0015 18.2 0.0 0.34 10.6 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 EDK39649.2 - 0.0043 17.3 0.0 0.011 16.0 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 EDK39649.2 - 0.0047 16.7 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EDK39649.2 - 0.0084 16.1 0.2 0.13 12.2 0.0 2.5 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_2 PF07724.14 EDK39649.2 - 0.01 16.0 0.0 0.059 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_3 PF07726.11 EDK39649.2 - 0.026 14.4 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDK39649.2 - 0.027 14.4 0.4 0.11 12.4 0.0 2.1 2 1 1 3 3 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 EDK39649.2 - 0.031 14.0 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 EDK39649.2 - 0.034 14.1 0.0 0.085 12.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 EDK39649.2 - 0.042 13.2 0.2 0.11 11.9 0.1 1.7 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDK39649.2 - 0.046 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EDK39649.2 - 0.062 13.8 0.0 0.17 12.4 0.0 1.8 1 1 0 1 1 1 0 ABC transporter DNA_pol3_delta2 PF13177.6 EDK39649.2 - 0.062 13.1 0.1 0.85 9.4 0.0 2.4 2 1 1 3 3 2 0 DNA polymerase III, delta subunit AAA_7 PF12775.7 EDK39649.2 - 0.062 12.8 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 EDK39649.2 - 0.092 11.9 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_25 PF13481.6 EDK39649.2 - 0.12 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDK39649.2 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.6 EDK39649.2 - 0.14 12.5 0.4 1.2 9.4 0.3 2.3 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EDK39649.2 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDK39649.2 - 0.22 11.2 0.2 0.72 9.5 0.1 1.9 2 1 0 2 2 2 0 AAA domain LIM_bind PF01803.16 EDK39650.2 - 6e-28 98.0 1.9 7.4e-26 91.2 0.0 3.0 2 1 0 2 2 2 1 LIM-domain binding protein PAPA-1 PF04795.12 EDK39652.2 - 5e-18 65.7 11.4 5e-18 65.7 11.4 3.3 2 1 2 4 4 4 1 PAPA-1-like conserved region SDA1 PF05285.12 EDK39652.2 - 5.3 6.4 33.3 1.5 8.2 30.5 1.4 1 1 0 1 1 1 0 SDA1 Neugrin PF06413.11 EDK39654.2 - 1.4e-08 35.0 4.2 2.5e-08 34.2 4.2 1.6 1 1 0 1 1 1 1 Neugrin Skp1 PF01466.19 EDK39654.2 - 0.043 13.9 0.1 0.08 13.1 0.1 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain DUF4733 PF15878.5 EDK39654.2 - 0.072 13.6 3.2 0.32 11.5 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4733) VID27 PF08553.10 EDK39655.2 - 1.2e-144 481.8 4.3 2.1e-144 481.0 4.3 1.4 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EDK39655.2 - 3.5e-52 176.7 0.7 8.3e-52 175.5 0.1 2.0 2 0 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 EDK39655.2 - 6.6e-25 87.5 2.5 9.2e-25 87.0 1.1 2.1 2 0 0 2 2 2 1 VID27 PH-like domain Mrx7 PF10906.8 EDK39656.2 - 1.2e-27 95.9 0.2 1.3e-27 95.8 0.2 1.0 1 0 0 1 1 1 1 MIOREX complex component 7 GLEYA PF10528.9 EDK39656.2 - 0.078 13.4 0.0 0.11 12.9 0.0 1.3 1 1 0 1 1 1 0 GLEYA domain RGS PF00615.19 EDK39657.2 - 1.5e-08 34.9 0.0 2.3e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain bZIP_2 PF07716.15 EDK39658.2 - 2.1e-12 46.9 8.0 3.8e-12 46.1 8.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper TSC22 PF01166.18 EDK39658.2 - 0.0062 16.8 2.1 0.014 15.7 2.1 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF3446 PF11928.8 EDK39658.2 - 0.016 15.5 0.4 0.37 11.1 0.1 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain SOGA PF11365.8 EDK39658.2 - 0.037 15.2 1.8 0.037 15.2 1.8 1.9 2 0 0 2 2 2 0 Protein SOGA bZIP_1 PF00170.21 EDK39658.2 - 0.071 13.2 10.8 0.24 11.6 10.7 1.9 1 1 0 1 1 1 0 bZIP transcription factor YabA PF06156.13 EDK39658.2 - 0.1 13.2 5.0 0.23 12.1 5.0 1.5 1 0 0 1 1 1 0 Initiation control protein YabA CPSase_L_D2 PF02786.17 EDK39659.2 - 6.3e-82 274.2 0.2 9.8e-82 273.5 0.2 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EDK39659.2 - 3.4e-66 222.8 0.0 5.8e-66 222.0 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EDK39659.2 - 2.4e-39 134.3 0.0 4.5e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDK39659.2 - 3.9e-30 104.1 0.0 9.2e-30 102.9 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EDK39659.2 - 6.8e-24 84.8 0.0 1.6e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EDK39659.2 - 6.8e-18 64.3 4.6 6.8e-18 64.3 4.6 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDK39659.2 - 7.7e-09 35.2 1.4 0.0039 17.0 0.0 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EDK39659.2 - 2e-06 27.5 0.0 4.9e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDK39659.2 - 7.9e-06 25.5 0.0 1.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain DUF2118 PF09891.9 EDK39659.2 - 0.00062 19.7 0.0 1.3 9.0 0.4 2.9 3 0 0 3 3 3 2 Uncharacterized protein conserved in archaea (DUF2118) ATP-grasp_3 PF02655.14 EDK39659.2 - 0.0009 19.3 0.1 0.0033 17.5 0.1 2.0 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EDK39659.2 - 0.0055 16.0 0.0 0.033 13.5 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp PTS_EIIA_1 PF00358.20 EDK39659.2 - 0.0095 15.7 2.3 0.025 14.3 0.5 2.8 3 0 0 3 3 3 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GCV_H PF01597.19 EDK39659.2 - 0.0096 15.8 1.2 0.066 13.1 0.5 2.6 1 1 1 2 2 2 1 Glycine cleavage H-protein RnfC_N PF13375.6 EDK39659.2 - 0.026 14.5 1.1 0.27 11.2 0.7 2.8 2 1 1 3 3 2 0 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 EDK39659.2 - 0.033 14.9 0.3 11 6.8 0.1 2.8 2 0 0 2 2 2 0 HlyD family secretion protein PYNP_C PF07831.13 EDK39659.2 - 0.054 13.1 5.0 0.84 9.3 0.1 3.4 2 1 1 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain HlyD_D23 PF16576.5 EDK39659.2 - 0.077 12.2 0.3 0.97 8.6 0.1 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_4 PF13535.6 EDK39659.2 - 0.079 12.5 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DASH_Duo1 PF08651.10 EDK39660.1 - 2.1e-22 78.6 3.6 2.1e-22 78.6 3.6 1.7 2 0 0 2 2 2 1 DASH complex subunit Duo1 APG17 PF04108.12 EDK39660.1 - 0.0018 17.4 3.5 0.0018 17.4 3.5 1.6 1 1 1 2 2 2 1 Autophagy protein Apg17 DASH_Dad2 PF08654.10 EDK39660.1 - 0.0039 17.6 3.5 0.0039 17.6 3.5 1.5 1 1 0 1 1 1 1 DASH complex subunit Dad2 eIF3_N PF09440.10 EDK39660.1 - 0.0083 16.6 3.1 0.012 16.1 1.3 1.8 1 1 1 2 2 2 1 eIF3 subunit 6 N terminal domain DUF465 PF04325.13 EDK39660.1 - 0.011 15.8 0.7 0.1 12.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF465) bZIP_2 PF07716.15 EDK39660.1 - 0.1 12.7 8.3 1.7 8.8 5.6 2.4 2 0 0 2 2 2 0 Basic region leucine zipper CAP59_mtransfer PF11735.8 EDK39660.1 - 0.11 12.2 1.8 0.13 12.0 1.8 1.1 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 DUF484 PF04340.12 EDK39660.1 - 0.11 12.1 3.5 0.17 11.5 3.5 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF484 Enkurin PF13864.6 EDK39660.1 - 0.14 12.6 6.4 9.2 6.8 3.6 2.5 2 1 0 2 2 2 0 Calmodulin-binding Tropomyosin_1 PF12718.7 EDK39660.1 - 0.16 12.2 10.0 3 8.0 10.1 2.1 1 1 0 1 1 1 0 Tropomyosin like DivIC PF04977.15 EDK39660.1 - 0.2 11.4 5.7 0.53 10.1 1.2 2.3 2 1 0 2 2 2 0 Septum formation initiator Cortex-I_coil PF09304.10 EDK39660.1 - 0.23 11.7 6.8 0.23 11.7 3.5 2.1 1 1 0 2 2 2 0 Cortexillin I, coiled coil GAS PF13851.6 EDK39660.1 - 0.42 9.9 9.8 0.68 9.2 4.9 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Hemerythrin PF01814.23 EDK39660.1 - 0.54 10.9 4.3 9.8 6.8 4.3 2.0 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain Nnf1 PF03980.14 EDK39660.1 - 0.7 10.3 10.9 1.3 9.4 2.8 2.9 2 1 1 3 3 3 0 Nnf1 Syntaxin-6_N PF09177.11 EDK39660.1 - 0.72 10.5 9.0 0.85 10.2 5.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal APG6_N PF17675.1 EDK39660.1 - 0.81 10.2 12.7 5.8 7.5 7.8 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region FUSC PF04632.12 EDK39660.1 - 1.2 7.5 3.4 1.4 7.3 3.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family NYD-SP28_assoc PF14775.6 EDK39660.1 - 1.5 9.0 6.6 0.92 9.7 2.4 2.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain Med31 PF05669.12 EDK39661.1 - 1.2e-37 127.8 5.2 1.4e-37 127.6 5.2 1.0 1 0 0 1 1 1 1 SOH1 Scs3p PF10261.9 EDK39662.2 - 1.9e-71 240.4 19.7 5.7e-70 235.6 19.7 2.0 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM DUF1129 PF06570.11 EDK39662.2 - 0.0084 15.6 2.1 0.0084 15.6 2.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1129) He_PIG PF05345.12 EDK39663.2 - 9.3e-15 54.6 17.6 1.5e-08 34.7 1.8 4.8 6 0 0 6 6 5 3 Putative Ig domain Mid2 PF04478.12 EDK39663.2 - 1.7e-05 24.7 1.1 0.00046 20.0 0.0 3.1 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor TMEM154 PF15102.6 EDK39663.2 - 0.00067 19.6 0.2 0.00067 19.6 0.2 2.6 2 1 1 3 3 3 1 TMEM154 protein family SKG6 PF08693.10 EDK39663.2 - 0.0069 15.8 1.7 0.0069 15.8 1.7 2.1 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Herpes_pp85 PF04637.12 EDK39663.2 - 0.0077 14.7 3.2 0.013 13.9 3.2 1.2 1 0 0 1 1 1 1 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF4448 PF14610.6 EDK39663.2 - 0.019 14.8 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Herpes_gE PF02480.16 EDK39663.2 - 0.031 13.0 0.0 0.047 12.4 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E MLANA PF14991.6 EDK39663.2 - 0.065 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein melan-A EphA2_TM PF14575.6 EDK39663.2 - 0.075 13.9 0.0 0.23 12.4 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Pox_A12 PF04651.13 EDK39663.2 - 0.11 12.6 6.2 0.32 11.0 6.2 1.8 1 0 0 1 1 1 0 Poxvirus A12 protein Shisa PF13908.6 EDK39663.2 - 0.15 12.3 2.5 0.6 10.3 2.4 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator 4HBT PF03061.22 EDK39664.2 - 0.0042 17.4 2.4 3.4 8.1 0.0 3.5 3 2 0 3 3 3 2 Thioesterase superfamily Transket_pyr PF02779.24 EDK39665.1 - 4.9e-45 153.4 0.0 8e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDK39665.1 - 9.2e-37 125.7 0.1 2.1e-36 124.6 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Acatn PF13000.7 EDK39666.2 - 4.1e-187 623.0 18.3 8.1e-126 420.7 12.2 2.3 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 zinc_ribbon_10 PF10058.9 EDK39666.2 - 0.18 11.5 0.1 0.34 10.7 0.1 1.4 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein PQ-loop PF04193.14 EDK39667.2 - 5.2e-31 106.2 15.7 2.3e-16 59.3 1.5 2.9 3 0 0 3 3 3 2 PQ loop repeat ubiquitin PF00240.23 EDK39668.1 - 0.00025 20.8 0.2 0.00031 20.4 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EDK39668.1 - 0.0048 17.3 0.2 0.023 15.2 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Metallophos PF00149.28 EDK39669.2 - 8.4e-35 121.1 0.9 1.2e-34 120.6 0.9 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EDK39669.2 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Aminotran_3 PF00202.21 EDK39670.2 - 1.6e-113 379.4 0.1 1.9e-113 379.2 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDK39670.2 - 0.00078 18.7 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II OAM_alpha PF16552.5 EDK39670.2 - 0.0017 18.2 0.0 0.0091 15.9 0.0 2.1 2 0 0 2 2 2 1 D-ornithine 4,5-aminomutase alpha-subunit Cation_efflux PF01545.21 EDK39671.2 - 0.00026 20.8 13.5 0.00049 19.9 13.5 1.5 1 1 0 1 1 1 1 Cation efflux family QWRF PF04484.12 EDK39671.2 - 3.1 7.5 9.5 4.6 6.9 9.5 1.2 1 0 0 1 1 1 0 QWRF family Med12 PF09497.10 EDK39672.2 - 3.2e-25 88.2 0.1 8.8e-25 86.8 0.1 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Myosin_head PF00063.21 EDK39673.2 - 3.1e-222 739.5 9.2 3.8e-222 739.3 9.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EDK39673.2 - 2e-48 164.5 0.0 3.8e-48 163.7 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EDK39673.2 - 1.3e-06 27.9 0.1 2.5e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain Hpr_kinase_C PF07475.12 EDK39673.2 - 5.8e-05 22.7 0.2 0.19 11.2 0.0 2.5 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain SH3_9 PF14604.6 EDK39673.2 - 0.00015 21.6 0.0 0.00036 20.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK39673.2 - 0.0032 17.1 0.0 0.0068 16.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Med15_fungi PF05397.12 EDK39673.2 - 0.015 15.5 0.2 0.71 10.2 0.0 2.9 2 0 0 2 2 2 0 Mediator complex subunit 15 AAA_16 PF13191.6 EDK39673.2 - 0.028 14.8 0.0 0.085 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EDK39673.2 - 0.12 12.7 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDK39673.2 - 0.13 12.7 0.0 0.47 10.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EDK39673.2 - 0.15 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain IQ PF00612.27 EDK39673.2 - 6.3 6.9 7.7 1.9 8.5 3.7 2.2 1 1 1 2 2 2 0 IQ calmodulin-binding motif WD40 PF00400.32 EDK39674.2 - 8.5e-62 203.6 38.9 8.8e-11 42.2 0.2 9.1 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39674.2 - 5.4e-18 65.1 5.3 7.5e-05 23.0 0.2 5.9 3 3 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK39674.2 - 7.3e-09 35.8 0.0 0.0016 18.4 0.0 3.2 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDK39674.2 - 1.2e-06 27.8 1.2 0.65 8.9 0.0 4.7 3 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EDK39674.2 - 1.9e-05 23.6 1.4 0.00029 19.7 0.8 2.6 1 1 1 2 2 2 1 Nup133 N terminal like Nup160 PF11715.8 EDK39674.2 - 6.4e-05 21.8 6.0 0.19 10.4 0.1 4.3 4 1 1 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDK39674.2 - 0.0029 17.0 0.0 0.69 9.2 0.0 3.6 4 0 0 4 4 4 1 WD40-like domain Frtz PF11768.8 EDK39674.2 - 0.0047 15.3 0.0 0.49 8.6 0.0 2.6 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 EDK39674.2 - 0.052 13.5 1.1 11 6.1 0.1 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EDK39674.2 - 0.054 12.0 0.1 0.73 8.3 0.1 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain FAD_binding_9 PF08021.11 EDK39674.2 - 0.15 12.2 0.0 0.42 10.8 0.0 1.7 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain 7TM_GPCR_Sri PF10327.9 EDK39675.2 - 0.0011 18.2 1.6 0.72 9.0 0.1 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Sri Pkinase PF00069.25 EDK39676.2 - 1.6e-68 230.9 0.0 5.4e-68 229.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39676.2 - 8.3e-38 130.1 1.1 1e-36 126.6 0.1 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK39676.2 - 1.5e-05 24.5 0.1 5.7e-05 22.6 0.1 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EDK39676.2 - 0.00051 20.0 0.1 0.0017 18.3 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDK39676.2 - 0.0033 16.5 0.5 0.008 15.3 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 RIO1 PF01163.22 EDK39676.2 - 0.022 14.4 0.9 0.054 13.1 0.4 1.8 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 EDK39676.2 - 0.026 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Img2 PF05046.14 EDK39677.1 - 1.6e-16 60.4 0.5 2.1e-16 60.0 0.5 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) zf-C2H2 PF00096.26 EDK39678.2 - 3.7e-14 52.3 40.6 5.1e-05 23.5 0.6 8.5 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK39678.2 - 4e-11 42.8 3.3 5.2e-08 33.0 0.4 8.8 10 0 0 10 10 10 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK39678.2 - 4.3e-06 27.1 50.6 0.0023 18.6 0.5 9.2 8 0 0 8 8 8 3 C2H2-type zinc finger FOXP-CC PF16159.5 EDK39678.2 - 1.2e-05 25.9 3.8 0.00039 21.0 0.1 7.3 5 3 2 7 7 7 3 FOXP coiled-coil domain Zap1_zf2 PF18217.1 EDK39678.2 - 3.7e-05 23.6 6.0 3.7e-05 23.6 6.0 5.3 5 0 0 5 5 5 1 Zap1 zinc finger 2 zf-C2H2_6 PF13912.6 EDK39678.2 - 0.00015 21.6 17.8 0.069 13.2 0.5 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf_ZIC PF18366.1 EDK39678.2 - 0.053 13.6 0.6 0.053 13.6 0.6 6.0 6 1 1 7 7 7 0 Zic proteins zinc finger domain zf-C2H2_11 PF16622.5 EDK39678.2 - 0.077 12.8 0.3 0.077 12.8 0.3 4.8 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EDK39678.2 - 1.1 9.6 0.0 1.1 9.6 0.0 6.4 7 2 0 7 7 7 0 Zinc-finger double-stranded RNA-binding PAT1 PF09770.9 EDK39680.2 - 3.3e-112 376.4 53.1 2.1e-105 353.9 36.6 3.5 1 1 1 2 2 2 2 Topoisomerase II-associated protein PAT1 Chorismate_bind PF00425.18 EDK39681.2 - 1.3e-78 264.2 0.0 2e-78 263.5 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EDK39681.2 - 9.7e-27 94.0 0.0 1.4e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EDK39681.2 - 2.7e-21 76.3 0.0 7.4e-21 74.8 0.0 1.8 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EDK39681.2 - 0.0012 18.7 0.0 0.0028 17.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 F-box-like PF12937.7 EDK39682.2 - 1.2e-07 31.5 0.8 4.1e-07 29.8 0.8 2.1 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EDK39682.2 - 0.00018 21.3 0.0 0.00043 20.1 0.0 1.6 1 0 0 1 1 1 1 F-box F-box PF00646.33 EDK39682.2 - 0.012 15.5 0.2 0.033 14.1 0.0 1.8 2 0 0 2 2 2 0 F-box domain A_deaminase PF00962.22 EDK39682.2 - 0.042 13.2 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Adenosine/AMP deaminase AZUL PF16558.5 EDK39682.2 - 0.63 10.3 5.1 1.6 9.0 0.1 3.1 3 0 0 3 3 3 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A COX7a PF02238.15 EDK39683.1 - 3.1e-23 81.9 0.3 3.4e-23 81.8 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII zf-C3HC4 PF00097.25 EDK39684.2 - 2.6e-07 30.4 12.5 5.7e-07 29.3 12.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK39684.2 - 1e-06 28.5 12.2 1e-06 28.5 12.2 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK39684.2 - 2e-06 27.6 10.5 2e-06 27.6 10.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK39684.2 - 3.2e-06 27.1 6.6 3.2e-06 27.1 6.6 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EDK39684.2 - 5.4e-06 26.6 12.8 5.4e-06 26.6 12.8 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EDK39684.2 - 1.3e-05 25.0 12.1 1.3e-05 25.0 12.1 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDK39684.2 - 5.5e-05 23.0 12.4 5.5e-05 23.0 12.4 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDK39684.2 - 0.00015 21.8 10.6 0.00015 21.8 10.6 2.5 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDK39684.2 - 0.004 17.4 11.5 0.004 17.4 11.5 1.9 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EDK39684.2 - 0.021 14.7 4.1 0.021 14.7 4.1 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DUF3716 PF12511.8 EDK39684.2 - 0.037 14.1 0.8 0.037 14.1 0.8 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF3716) zf-RING_10 PF16685.5 EDK39684.2 - 0.52 10.5 12.3 0.052 13.7 7.8 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EDK39684.2 - 4.1 7.5 10.9 0.14 12.2 4.5 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Kri1_C PF12936.7 EDK39687.2 - 2.4e-32 110.9 2.9 2.4e-32 110.9 2.9 5.4 3 2 2 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 EDK39687.2 - 1.2e-19 70.8 15.8 1.2e-19 70.8 15.8 6.7 3 2 3 7 7 7 1 KRI1-like family DUF1479 PF07350.12 EDK39688.2 - 3.7e-158 526.7 0.0 4.3e-158 526.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EDK39688.2 - 0.00062 20.1 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) ABC_trans_N PF14510.6 EDK39689.2 - 6.6e-21 74.7 0.0 1.9e-20 73.2 0.0 1.8 2 0 0 2 2 2 1 ABC-transporter N-terminal ABC_tran PF00005.27 EDK39689.2 - 1.7e-20 73.9 0.0 5.1e-20 72.4 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.6 EDK39689.2 - 0.083 13.4 0.2 0.23 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDK39689.2 - 0.13 12.7 0.2 4.2 7.8 0.1 2.7 2 1 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 EDK39691.2 - 2e-31 109.1 19.4 2.3e-31 108.9 19.4 1.1 1 0 0 1 1 1 1 ABC-2 type transporter CPP1-like PF11833.8 EDK39691.2 - 1.6 8.4 6.0 1.7 8.3 1.3 2.1 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF373 PF04123.13 EDK39691.2 - 4.5 6.6 6.3 6.2 6.2 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2304 PF10066.9 EDK39691.2 - 6.6 7.0 11.9 0.4 10.9 3.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) ABC2_membrane PF01061.24 EDK39692.1 - 7.5e-43 146.4 24.0 7.5e-43 146.4 24.0 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EDK39692.1 - 9.9e-20 71.5 0.0 2.6e-19 70.1 0.0 1.8 2 0 0 2 2 1 1 ABC transporter RsgA_GTPase PF03193.16 EDK39692.1 - 2.3e-06 27.6 0.0 9.3e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EDK39692.1 - 8.2e-05 22.3 0.1 0.00018 21.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDK39692.1 - 0.00029 21.3 0.0 0.00062 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain PDR_CDR PF06422.12 EDK39692.1 - 0.0003 20.6 5.3 0.00031 20.6 0.3 3.2 3 0 0 3 3 2 1 CDR ABC transporter AAA_21 PF13304.6 EDK39692.1 - 0.0021 18.0 0.3 1.3 8.8 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 EDK39692.1 - 0.0033 17.2 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EDK39692.1 - 0.0091 16.5 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EDK39692.1 - 0.013 14.9 0.0 0.36 10.2 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EDK39692.1 - 0.023 14.9 0.0 0.053 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK39692.1 - 0.037 13.8 0.0 0.093 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EDK39692.1 - 0.056 12.2 0.0 0.09 11.5 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 EDK39692.1 - 0.064 13.3 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EDK39692.1 - 0.082 13.2 0.3 0.21 11.8 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDK39692.1 - 0.18 11.5 0.0 0.4 10.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ferlin_C PF16165.5 EDK39692.1 - 0.81 9.6 4.7 0.23 11.4 0.5 2.2 2 0 0 2 2 2 0 Ferlin C-terminus MFS_1 PF07690.16 EDK39693.2 - 4.8e-44 150.7 15.6 4.8e-44 150.7 15.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EDK39693.2 - 0.17 10.2 4.5 0.13 10.5 1.0 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Exo84_C PF16528.5 EDK39694.2 - 8.7e-18 64.9 6.3 8.7e-18 64.9 6.3 3.4 3 2 0 3 3 3 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EDK39694.2 - 0.00023 21.2 6.0 0.00023 21.2 6.0 2.7 2 1 1 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 EDK39694.2 - 0.0011 19.1 8.2 0.0069 16.5 0.5 2.8 2 1 0 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 Exonuc_VII_S PF02609.16 EDK39694.2 - 0.0044 17.1 0.8 0.017 15.2 0.1 2.4 3 0 0 3 3 3 1 Exonuclease VII small subunit Sec16 PF12932.7 EDK39694.2 - 2.7 8.6 6.3 0.92 10.1 0.5 3.1 3 1 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region ANAPC4_WD40 PF12894.7 EDK39695.2 - 1.7e-08 34.7 1.5 0.016 15.5 0.0 6.1 3 2 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK39695.2 - 4.5e-08 33.6 13.2 0.0045 17.8 0.0 6.8 6 1 0 6 6 6 3 WD domain, G-beta repeat LisH PF08513.11 EDK39695.2 - 5.9e-06 26.0 0.4 5.9e-06 26.0 0.4 2.2 2 0 0 2 2 2 1 LisH eIF2A PF08662.11 EDK39695.2 - 9.2e-05 22.4 0.6 0.048 13.5 0.0 3.7 4 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A UPF0139 PF03669.13 EDK39696.2 - 1e-05 25.3 0.0 1.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) SIP1 PF04938.12 EDK39697.2 - 2e-26 93.0 0.1 2.8e-26 92.6 0.1 1.1 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Tfb4 PF03850.14 EDK39698.2 - 5e-108 360.8 1.4 5.8e-108 360.6 1.4 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 GxGYxYP_C PF14323.6 EDK39698.2 - 0.023 14.6 0.3 0.032 14.1 0.3 1.2 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain Rad50_zn_hook PF04423.14 EDK39698.2 - 0.034 14.0 0.1 0.072 12.9 0.1 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif DUF4776 PF16003.5 EDK39698.2 - 0.76 8.7 1.8 1.2 8.0 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) dCMP_cyt_deam_1 PF00383.23 EDK39700.2 - 2e-21 75.7 0.0 2.8e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDK39700.2 - 9.5e-21 74.0 0.0 1.2e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EDK39700.2 - 0.00066 19.8 0.1 0.002 18.2 0.0 1.7 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 EDK39700.2 - 0.0015 18.6 1.0 0.043 13.9 1.2 2.1 1 1 1 2 2 2 1 Bd3614-like deaminase APOBEC2 PF18772.1 EDK39700.2 - 0.007 16.4 0.1 0.028 14.5 0.0 1.8 2 0 0 2 2 2 1 APOBEC2 NAD1 PF18778.1 EDK39700.2 - 0.0098 16.0 0.1 0.046 13.8 0.0 1.8 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 EDK39700.2 - 0.013 15.6 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 APOBEC3 APOBEC_N PF08210.11 EDK39700.2 - 0.023 14.6 0.4 0.068 13.1 0.3 1.8 1 1 0 1 1 1 0 APOBEC-like N-terminal domain NAD2 PF18782.1 EDK39700.2 - 0.029 14.5 0.1 0.083 13.0 0.0 1.7 1 1 1 2 2 2 0 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 EDK39700.2 - 0.033 14.1 0.0 0.051 13.5 0.0 1.3 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Pkinase PF00069.25 EDK39701.2 - 1.2e-16 60.9 0.0 3.5e-16 59.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39701.2 - 1e-09 38.1 0.0 3.1e-09 36.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EDK39701.2 - 4e-06 27.4 4.8 0.0025 18.6 0.2 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat HEAT PF02985.22 EDK39701.2 - 0.0036 17.4 2.5 2.6 8.5 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EDK39701.2 - 0.017 15.6 1.4 3.8 8.1 0.0 4.1 3 1 1 4 4 4 0 HEAT-like repeat Hira PF07569.11 EDK39701.2 - 0.056 13.2 1.2 18 5.0 0.1 3.4 3 0 0 3 3 3 0 TUP1-like enhancer of split Cofilin_ADF PF00241.20 EDK39702.1 - 1.2e-18 67.0 0.0 1.3e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DSPc PF00782.20 EDK39703.2 - 1.2e-22 80.1 0.0 2.6e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.6 EDK39703.2 - 4.9e-11 43.2 0.0 4.8e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.27 EDK39703.2 - 1.3e-05 24.9 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EDK39703.2 - 0.0068 16.1 0.3 0.012 15.3 0.3 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EDK39703.2 - 0.014 15.5 0.2 0.065 13.3 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate DUF3439 PF11921.8 EDK39703.2 - 0.2 11.6 4.1 2.1 8.3 4.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) SWI-SNF_Ssr4 PF08549.10 EDK39703.2 - 3.7 6.1 10.1 5 5.6 10.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Complex1_LYR PF05347.15 EDK39704.2 - 0.46 10.6 0.0 0.46 10.6 0.0 3.5 4 0 0 4 4 4 0 Complex 1 protein (LYR family) RPAP2_Rtr1 PF04181.13 EDK39705.2 - 2e-22 79.3 0.7 3.1e-22 78.7 0.7 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF747 PF05346.11 EDK39706.2 - 1.3e-93 314.0 11.2 1.3e-93 314.0 11.2 1.7 2 0 0 2 2 2 1 Eukaryotic membrane protein family COX15-CtaA PF02628.15 EDK39707.2 - 4.2e-110 367.8 6.4 5.3e-110 367.5 6.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Cytochrom_B561 PF03188.16 EDK39707.2 - 0.0051 16.9 0.6 0.016 15.3 0.4 1.9 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF3624 PF12292.8 EDK39707.2 - 0.0078 16.6 2.0 0.053 13.9 0.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3624) Fumarate_red_C PF02300.17 EDK39707.2 - 0.0097 16.0 0.4 0.16 12.0 0.3 2.5 2 0 0 2 2 2 1 Fumarate reductase subunit C DUF4491 PF14898.6 EDK39707.2 - 0.034 14.6 1.5 0.51 10.8 0.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) AMP-binding PF00501.28 EDK39709.2 - 6.6e-62 209.5 0.0 8e-62 209.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDK39709.2 - 3.1e-05 24.9 0.0 6.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PGK PF00162.19 EDK39710.1 - 2.6e-153 510.5 1.6 2.9e-153 510.3 1.6 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Fes1 PF08609.10 EDK39711.2 - 1.3e-19 70.8 2.3 1.3e-19 70.8 2.3 2.5 3 0 0 3 3 3 1 Nucleotide exchange factor Fes1 SIL1 PF16782.5 EDK39711.2 - 4.3e-09 36.0 1.7 7e-09 35.3 0.9 1.5 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 TAF1_subA PF14929.6 EDK39711.2 - 0.019 14.4 0.2 0.03 13.7 0.2 1.4 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A ERCC4 PF02732.15 EDK39713.2 - 5.3e-21 75.4 1.3 8.8e-21 74.7 1.3 1.3 1 0 0 1 1 1 1 ERCC4 domain Sec8_exocyst PF04048.14 EDK39714.2 - 3.8e-52 176.0 4.9 3.8e-52 176.0 4.9 2.6 4 0 0 4 4 4 1 Sec8 exocyst complex component specific domain Siah-Interact_N PF09032.11 EDK39714.2 - 0.016 15.5 0.4 0.078 13.3 0.2 2.3 2 0 0 2 2 2 0 Siah interacting protein, N terminal RNA_pol_Rpb2_5 PF04567.17 EDK39714.2 - 0.03 14.9 0.0 0.11 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 5 DUF1664 PF07889.12 EDK39714.2 - 0.24 11.5 1.4 0.91 9.6 1.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sec5 PF15469.6 EDK39714.2 - 0.31 10.8 12.1 0.19 11.5 6.0 2.8 2 0 0 2 2 2 0 Exocyst complex component Sec5 MCPsignal PF00015.21 EDK39714.2 - 3.1 7.6 4.6 1.4 8.7 0.4 2.5 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ctr PF04145.15 EDK39715.2 - 7.9e-26 91.4 0.3 1.1e-25 91.0 0.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family CaMKII_AD PF08332.10 EDK39715.2 - 0.16 12.1 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain DUF4229 PF14012.6 EDK39715.2 - 9.4 6.4 9.0 0.33 11.1 2.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) zf-C2H2 PF00096.26 EDK39716.2 - 0.012 16.0 12.7 5.9 7.6 0.0 4.0 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK39716.2 - 0.032 15.1 7.8 14 6.8 0.0 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger SIP1 PF04938.12 EDK39716.2 - 0.15 11.8 1.1 1.3 8.7 0.5 2.1 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) zf-H2C2_2 PF13465.6 EDK39717.2 - 0.0053 17.1 1.4 0.0053 17.1 1.4 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-Di19 PF05605.12 EDK39717.2 - 0.034 14.4 2.2 0.04 14.2 0.4 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EDK39717.2 - 0.075 13.9 12.9 3 8.9 0.9 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EDK39717.2 - 0.25 11.9 15.3 16 6.2 2.5 4.3 3 1 0 3 3 3 0 Zinc finger, C2H2 type Gcd10p PF04189.13 EDK39717.2 - 0.33 10.0 5.5 0.48 9.5 5.5 1.2 1 0 0 1 1 1 0 Gcd10p family Presenilin PF01080.17 EDK39717.2 - 7.5 5.2 5.9 9.9 4.8 5.9 1.1 1 0 0 1 1 1 0 Presenilin Ribosomal_L15e PF00827.17 EDK39718.1 - 2.7e-88 294.7 12.7 3.3e-88 294.4 12.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 AICARFT_IMPCHas PF01808.18 EDK39719.1 - 1.9e-92 309.9 0.0 2.6e-92 309.4 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EDK39719.1 - 1.3e-23 83.0 0.0 3.9e-23 81.4 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain DUF3664 PF12406.8 EDK39719.1 - 0.015 15.9 0.2 0.033 14.8 0.2 1.5 1 0 0 1 1 1 0 Surface protein DnaJ PF00226.31 EDK39720.2 - 5.4e-16 58.5 0.4 1.5e-15 57.1 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EDK39720.2 - 0.0016 17.6 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain Acetyltransf_1 PF00583.25 EDK39721.1 - 4.3e-15 56.0 0.0 5.4e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK39721.1 - 3.8e-13 49.5 0.1 5.4e-13 49.0 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK39721.1 - 1.8e-11 44.3 0.1 2.9e-11 43.6 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK39721.1 - 3.8e-07 30.0 0.0 6.9e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EDK39721.1 - 0.003 17.6 0.0 0.0053 16.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK39721.1 - 0.028 14.6 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EDK39721.1 - 0.058 13.5 0.0 0.089 12.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EDK39721.1 - 0.11 12.0 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Mgm101p PF06420.12 EDK39721.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial genome maintenance MGM101 Cyt-b5 PF00173.28 EDK39722.1 - 2.8e-13 49.8 0.0 3.4e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_9 PF18444.1 EDK39723.2 - 4.3e-26 90.6 0.0 8.2e-26 89.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 EDK39723.2 - 2.3e-12 46.3 0.0 5e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain NTF2 PF02136.20 EDK39723.2 - 0.00026 21.6 0.1 0.031 14.8 0.1 2.8 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 EDK39723.2 - 0.00038 20.8 4.5 0.001 19.4 1.8 2.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EDK39723.2 - 0.0037 16.8 0.2 0.0075 15.8 0.2 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EDK39723.2 - 0.098 12.4 2.9 1.5 8.6 1.2 2.7 2 1 0 2 2 2 0 Leucine rich repeat PIGA PF08288.12 EDK39724.2 - 4.9e-46 155.2 1.9 3e-45 152.7 0.9 2.4 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EDK39724.2 - 2.7e-28 99.1 0.2 3.9e-28 98.6 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EDK39724.2 - 4.8e-27 94.6 0.0 7.6e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDK39724.2 - 8.2e-22 78.1 0.0 1.5e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDK39724.2 - 1.3e-10 42.0 0.0 2.5e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EDK39724.2 - 1.1e-05 25.5 0.1 3e-05 24.1 0.1 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EDK39724.2 - 0.01 16.2 0.0 0.043 14.2 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 CAP_GLY PF01302.25 EDK39725.2 - 7.5e-24 83.5 0.9 1.2e-23 82.9 0.9 1.3 1 0 0 1 1 1 1 CAP-Gly domain GAS PF13851.6 EDK39725.2 - 0.0083 15.5 6.0 0.0083 15.5 6.0 4.9 3 1 2 5 5 5 4 Growth-arrest specific micro-tubule binding STPPase_N PF16891.5 EDK39725.2 - 0.088 13.3 3.3 1e+02 3.4 0.1 4.7 4 0 0 4 4 4 0 Serine-threonine protein phosphatase N-terminal domain Spc7 PF08317.11 EDK39725.2 - 1 8.2 66.4 0.17 10.8 16.2 3.9 2 2 2 4 4 4 0 Spc7 kinetochore protein Matrilin_ccoil PF10393.9 EDK39725.2 - 1.8 8.5 12.8 16 5.5 0.7 5.0 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Prefoldin_3 PF13758.6 EDK39725.2 - 1.9 8.6 0.0 1.9 8.6 0.0 5.9 5 2 2 7 7 7 0 Prefoldin subunit AAA PF00004.29 EDK39727.2 - 2.5e-43 147.6 0.0 4.4e-43 146.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK39727.2 - 2.3e-10 40.1 0.0 4.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDK39727.2 - 1.8e-09 37.4 0.0 3.8e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EDK39727.2 - 5.7e-08 33.3 0.2 3.8e-05 24.1 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EDK39727.2 - 3.5e-06 27.1 0.1 6.2e-05 23.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDK39727.2 - 1.8e-05 24.9 0.0 3.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 EDK39727.2 - 4.9e-05 23.3 0.0 8.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EDK39727.2 - 7e-05 22.6 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDK39727.2 - 0.00022 21.5 0.1 0.022 15.0 0.1 2.5 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EDK39727.2 - 0.0016 17.7 0.1 0.003 16.8 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 EDK39727.2 - 0.0034 17.8 0.0 0.0077 16.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EDK39727.2 - 0.0043 16.5 0.1 0.0098 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDK39727.2 - 0.005 16.6 0.0 0.0099 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EDK39727.2 - 0.0052 17.3 0.0 0.019 15.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK39727.2 - 0.0079 16.4 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EDK39727.2 - 0.012 15.0 0.4 0.053 12.9 0.0 2.2 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.6 EDK39727.2 - 0.013 15.2 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDK39727.2 - 0.015 14.8 0.0 0.037 13.6 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EDK39727.2 - 0.017 15.3 0.2 0.052 13.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF4200 PF13863.6 EDK39727.2 - 0.024 15.0 0.3 0.057 13.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) PhoH PF02562.16 EDK39727.2 - 0.039 13.4 0.2 0.071 12.6 0.2 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 EDK39727.2 - 0.051 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDK39727.2 - 0.055 13.2 0.1 0.19 11.4 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.6 EDK39727.2 - 0.078 13.3 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EDK39727.2 - 0.091 11.8 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 EDK39727.2 - 0.098 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Prot_ATP_OB_N PF17758.1 EDK39727.2 - 0.15 11.8 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_30 PF13604.6 EDK39727.2 - 0.16 11.7 0.1 0.32 10.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDK39727.2 - 0.18 11.4 1.8 0.2 11.2 0.2 1.8 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EDK39727.2 - 0.18 11.5 0.2 0.6 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTP_transf_3 PF12804.7 EDK39728.2 - 4.7e-09 36.8 0.0 7.4e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 EDK39728.2 - 5.1e-07 29.2 4.6 0.0089 15.7 1.2 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EDK39728.2 - 5.2e-06 26.2 0.0 7.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EDK39728.2 - 0.026 14.3 3.5 4.2 7.2 0.4 2.7 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EDK39728.2 - 0.051 11.7 0.6 0.076 11.1 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) DUF4588 PF15251.6 EDK39729.2 - 6.1e-25 88.4 0.7 6.1e-25 88.4 0.7 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4588) DUF1525 PF07511.11 EDK39729.2 - 0.036 14.2 1.0 0.065 13.4 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Ploopntkinase3 PF18751.1 EDK39729.2 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Longin PF13774.6 EDK39730.2 - 1.5e-22 79.4 0.1 2.6e-22 78.7 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EDK39730.2 - 1.1e-14 53.9 0.1 2e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 EDK39730.2 - 0.0051 16.8 0.2 0.0075 16.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Mon1 PF03164.14 EDK39731.2 - 6.9e-116 387.6 3.7 8.3e-116 387.4 3.7 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Pneumo_M2 PF07380.11 EDK39731.2 - 0.2 12.0 1.6 2.1 8.7 0.0 3.1 3 0 0 3 3 3 0 Pneumovirus M2 protein RRF PF01765.19 EDK39732.2 - 1.1e-39 136.0 0.3 1.1e-39 136.0 0.3 1.9 1 1 1 2 2 2 1 Ribosome recycling factor STAS PF01740.21 EDK39732.2 - 0.029 14.0 0.1 0.062 12.9 0.1 1.6 1 0 0 1 1 1 0 STAS domain Peptidase_M3_N PF08439.10 EDK39732.2 - 0.039 14.2 0.3 0.099 12.9 0.3 1.7 1 0 0 1 1 1 0 Oligopeptidase F STAT_alpha PF01017.20 EDK39732.2 - 0.67 9.8 4.4 0.19 11.6 1.2 1.6 2 0 0 2 2 2 0 STAT protein, all-alpha domain Ipi1_N PF12333.8 EDK39733.2 - 5.9e-27 94.2 1.6 5.9e-27 94.2 1.6 2.3 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Cnd3 PF12719.7 EDK39733.2 - 0.0016 17.7 0.3 0.0023 17.2 0.3 1.2 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain Brr6_like_C_C PF10104.9 EDK39734.2 - 1.9e-43 147.4 0.1 2.8e-43 146.9 0.1 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain ZYG-11_interact PF05884.12 EDK39734.2 - 0.012 15.1 0.2 0.019 14.4 0.2 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 Tli4_N PF18443.1 EDK39734.2 - 0.021 15.2 0.2 0.051 13.9 0.2 1.6 1 0 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain TB2_DP1_HVA22 PF03134.19 EDK39735.2 - 0.0097 15.8 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Pex24p PF06398.11 EDK39735.2 - 0.072 12.1 0.3 0.089 11.8 0.3 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Sugar_tr PF00083.24 EDK39736.1 - 9.9e-64 215.8 2.6 1.1e-63 215.7 2.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39736.1 - 9.8e-19 67.5 3.3 1.3e-18 67.0 3.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 EDK39736.1 - 0.015 13.7 2.8 0.021 13.2 2.8 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector Phage_holin_2_3 PF16080.5 EDK39736.1 - 0.16 11.8 0.3 0.16 11.8 0.3 2.3 3 0 0 3 3 3 0 Bacteriophage holin family HP1 DUF2207 PF09972.9 EDK39736.1 - 7.8 5.1 5.7 6 5.5 4.2 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Sugar_tr PF00083.24 EDK39737.1 - 7.5e-46 156.9 16.4 8.4e-46 156.8 16.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Ilm1 PF10311.9 EDK39737.1 - 0.22 11.2 3.7 0.38 10.4 3.8 1.3 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 MFS_1 PF07690.16 EDK39739.2 - 7e-23 81.1 28.9 7e-23 81.1 28.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily V_ATPase_I PF01496.19 EDK39739.2 - 0.0092 14.0 0.0 0.014 13.4 0.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1980 PF09323.10 EDK39739.2 - 1.4 8.8 6.8 19 5.1 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1980) MFS_1 PF07690.16 EDK39740.2 - 4.1e-32 111.5 36.5 4.1e-32 111.5 36.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK39740.2 - 7.3e-06 25.1 8.7 7.3e-06 25.1 8.7 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter Aldolase_II PF00596.21 EDK39741.2 - 1e-44 152.7 0.2 1.2e-44 152.4 0.2 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Fer2_4 PF13510.6 EDK39741.2 - 0.33 11.0 1.2 10 6.2 0.3 2.6 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Pkinase PF00069.25 EDK39742.2 - 5.9e-62 209.4 0.0 7.8e-62 209.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39742.2 - 2.3e-33 115.6 0.0 3.1e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK39742.2 - 6.1e-06 25.3 0.2 1.4e-05 24.0 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EDK39742.2 - 0.0079 15.2 2.3 0.029 13.3 2.5 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDK39742.2 - 0.013 14.8 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF1917 PF08939.10 EDK39743.2 - 0.016 15.1 9.0 0.028 14.3 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) C1_1 PF00130.22 EDK39743.2 - 0.53 10.2 21.8 1.4 8.8 1.3 4.8 4 1 1 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2318 PF10080.9 EDK39743.2 - 0.84 9.8 14.6 6.7 6.9 1.8 3.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2318) Auto_anti-p27 PF06677.12 EDK39743.2 - 2.7 8.2 17.7 1.6 8.9 2.5 4.2 4 0 0 4 4 4 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4407 PF14362.6 EDK39743.2 - 9.1 5.5 11.2 16 4.8 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lin-8 PF03353.15 EDK39743.2 - 9.7 5.7 18.1 21 4.5 18.1 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.10 EDK39743.2 - 10 4.7 11.3 13 4.4 11.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RRM_1 PF00076.22 EDK39744.2 - 1.1e-18 66.8 0.6 2e-11 43.6 0.1 3.7 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK39744.2 - 0.00011 22.2 0.2 0.014 15.5 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif Sds3 PF08598.11 EDK39745.2 - 2e-43 148.9 0.0 2e-43 148.9 0.0 2.8 2 1 0 2 2 2 1 Sds3-like KIAA1430 PF13879.6 EDK39745.2 - 1.4 9.8 8.6 6.7 7.5 2.7 2.7 2 0 0 2 2 2 0 KIAA1430 homologue fn3_2 PF16893.5 EDK39747.2 - 3.8e-37 126.3 0.1 6.8e-37 125.5 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EDK39747.2 - 3.7e-24 84.4 0.0 7e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 EDK39747.2 - 8.6e-10 38.9 0.4 1.9e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDK39747.2 - 2.9e-06 27.1 0.0 4.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain DUF3006 PF11213.8 EDK39747.2 - 0.00011 22.3 0.1 0.00011 22.3 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 EDK39747.2 - 0.13 12.7 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Transcrip_reg PF01709.20 EDK39749.2 - 6.2e-70 235.3 0.6 7.1e-70 235.1 0.6 1.0 1 0 0 1 1 1 1 Transcriptional regulator Mito_carr PF00153.27 EDK39750.2 - 5.2e-69 228.2 1.5 2.7e-24 84.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PT-VENN PF04829.13 EDK39750.2 - 0.088 12.9 3.0 8.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif Abhydrolase_3 PF07859.13 EDK39751.2 - 0.017 15.0 0.1 0.079 12.8 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Aminotran_3 PF00202.21 EDK39752.2 - 4.2e-100 335.3 0.0 4.8e-100 335.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDK39752.2 - 0.0054 16.0 0.0 0.0076 15.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II TRF PF08558.10 EDK39753.2 - 2.4e-87 292.5 0.0 3.2e-87 292.1 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EDK39753.2 - 1.4e-06 28.4 0.7 4.9e-06 26.6 0.7 2.0 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK39753.2 - 0.0014 18.8 0.3 0.0035 17.6 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.32 EDK39754.2 - 2.2e-31 107.4 26.8 4.2e-06 27.4 1.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK39754.2 - 1.6e-11 44.4 0.4 0.0079 16.5 0.1 5.1 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK39754.2 - 0.00018 20.6 2.3 0.93 8.4 0.1 3.6 3 2 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein YEATS PF03366.16 EDK39755.2 - 7.8e-23 80.3 0.0 1.3e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EDK39755.2 - 0.00052 20.1 0.2 0.001 19.2 0.2 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YqeY PF09424.10 EDK39756.2 - 4.8e-18 65.6 2.7 6.1e-18 65.3 2.7 1.1 1 0 0 1 1 1 1 Yqey-like protein SBDS_C PF09377.10 EDK39756.2 - 0.016 15.3 0.1 0.044 13.8 0.1 1.7 1 1 0 1 1 1 0 SBDS protein C-terminal domain DnaJ-X PF14308.6 EDK39756.2 - 0.021 14.3 2.0 0.03 13.8 2.0 1.2 1 0 0 1 1 1 0 X-domain of DnaJ-containing YppG PF14179.6 EDK39756.2 - 0.04 14.6 0.9 0.063 14.0 0.7 1.4 1 1 0 1 1 1 0 YppG-like protein PYRIN PF02758.16 EDK39756.2 - 0.092 12.9 0.2 0.57 10.4 0.0 2.3 3 0 0 3 3 3 0 PAAD/DAPIN/Pyrin domain Helicase_IV_N PF12462.8 EDK39756.2 - 0.14 12.1 3.4 0.21 11.5 1.2 1.9 1 1 1 2 2 2 0 DNA helicase IV / RNA helicase N terminal DSPc PF00782.20 EDK39757.2 - 1.1e-15 57.7 0.1 9.2e-14 51.4 0.0 2.8 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Glyco_transf_11 PF01531.16 EDK39757.2 - 0.051 12.8 0.1 2.2 7.4 0.0 2.7 3 0 0 3 3 3 0 Glycosyl transferase family 11 Y_phosphatase PF00102.27 EDK39757.2 - 0.098 12.2 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Protein-tyrosine phosphatase DHFR_1 PF00186.19 EDK39759.2 - 1.2e-29 103.1 0.0 1.7e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Pyridox_oxase_2 PF12766.7 EDK39761.2 - 5.5e-29 100.7 0.0 1.1e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EDK39761.2 - 4.5e-07 30.0 0.0 1.1e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ras PF00071.22 EDK39762.2 - 1.1e-50 171.4 0.1 1.4e-50 171.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK39762.2 - 2.7e-17 63.1 0.0 5.4e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK39762.2 - 6.6e-08 32.2 0.0 9.1e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK39762.2 - 0.00018 21.1 0.1 0.0004 20.0 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK39762.2 - 0.00064 19.8 0.1 0.0012 18.9 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 EDK39762.2 - 0.0013 18.0 0.0 0.26 10.4 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EDK39762.2 - 0.005 16.8 0.8 2.6 7.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EDK39762.2 - 0.054 13.9 0.2 2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain ParA PF10609.9 EDK39762.2 - 0.1 12.0 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase GST_N_2 PF13409.6 EDK39763.2 - 1.1e-24 86.5 0.2 8e-24 83.7 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDK39763.2 - 1.6e-13 50.4 0.0 3.7e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDK39763.2 - 9.7e-06 25.7 0.0 2.2e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDK39763.2 - 3.6e-05 23.9 0.0 9e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDK39763.2 - 0.00039 20.8 0.1 1.6 9.2 0.0 2.9 3 0 0 3 3 3 2 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 EDK39763.2 - 0.036 14.6 0.0 0.12 12.9 0.0 1.8 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.26 EDK39764.2 - 2.4e-05 24.5 0.5 2.4e-05 24.5 0.5 4.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.7 EDK39764.2 - 0.017 15.5 3.0 0.27 11.7 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EDK39764.2 - 0.02 15.7 0.6 0.02 15.7 0.6 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK39764.2 - 0.14 12.5 0.5 0.14 12.5 0.5 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding CLN3 PF02487.17 EDK39764.2 - 1.1 8.3 3.9 0.21 10.6 0.4 1.5 2 0 0 2 2 2 0 CLN3 protein MCM PF00493.23 EDK39766.1 - 9.2e-88 293.1 0.2 1.3e-87 292.6 0.2 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM6_C PF18263.1 EDK39766.1 - 2.8e-31 107.9 0.8 5.1e-31 107.1 0.8 1.4 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EDK39766.1 - 6.5e-26 90.6 1.0 6.5e-26 90.6 1.0 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDK39766.1 - 1e-06 28.3 0.0 7.5e-06 25.5 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDK39766.1 - 0.0038 17.1 0.0 0.0078 16.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDK39766.1 - 0.0068 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain MCM_OB PF17207.3 EDK39767.2 - 4e-39 133.3 0.4 7.4e-39 132.5 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 EDK39767.2 - 2.4e-23 82.7 0.4 4.1e-23 81.9 0.4 1.4 1 0 0 1 1 1 1 MCM N-terminal domain Zn-ribbon_8 PF09723.10 EDK39767.2 - 0.05 13.7 1.8 0.16 12.1 1.8 1.8 1 0 0 1 1 1 0 Zinc ribbon domain MCM PF00493.23 EDK39767.2 - 0.051 12.7 0.0 0.08 12.0 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain HypA PF01155.19 EDK39767.2 - 0.057 13.4 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EDK39767.2 - 0.28 11.3 2.7 0.21 11.7 0.4 1.9 2 0 0 2 2 2 0 Double zinc ribbon tRNA_bind PF01588.20 EDK39768.1 - 5.8e-11 42.4 0.1 8.4e-11 41.9 0.1 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain AhpC-TSA PF00578.21 EDK39769.2 - 6.2e-33 113.4 0.0 8.5e-33 112.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK39769.2 - 9.5e-17 61.1 0.0 1.2e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDK39769.2 - 1.4e-12 47.2 0.0 2.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Fungal_trans PF04082.18 EDK39770.2 - 2.6e-16 59.4 0.7 4.6e-16 58.6 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39770.2 - 5e-09 36.1 10.2 8.9e-09 35.3 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PEGSRP PF07623.11 EDK39770.2 - 0.11 12.3 1.3 0.27 11.0 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1584) Rad51 PF08423.11 EDK39771.2 - 4.5e-131 435.7 0.0 5.5e-131 435.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EDK39771.2 - 3.9e-11 42.9 0.0 5.6e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EDK39771.2 - 2.4e-07 30.6 0.0 3.6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EDK39771.2 - 4.2e-07 30.5 0.2 9.4e-07 29.4 0.2 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 EDK39771.2 - 2.1e-06 27.2 0.2 5.4e-06 25.9 0.2 1.7 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EDK39771.2 - 0.0011 18.3 0.1 0.012 15.0 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EDK39771.2 - 0.043 13.0 0.2 0.1 11.7 0.1 1.6 2 0 0 2 2 2 0 PAXNEB protein HhH-GPD PF00730.25 EDK39771.2 - 0.048 14.1 0.0 0.11 13.0 0.0 1.7 1 1 1 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein ssDNA_TraI_N PF18272.1 EDK39771.2 - 0.12 12.4 0.1 0.35 10.9 0.1 1.8 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain Pkinase PF00069.25 EDK39772.2 - 2.4e-69 233.6 0.0 4.2e-69 232.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39772.2 - 1.1e-40 139.6 0.0 1.8e-40 138.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK39772.2 - 4.3e-10 39.4 0.0 7.8e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK39772.2 - 0.0014 18.0 0.1 0.0026 17.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK39772.2 - 0.0016 18.4 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDK39772.2 - 0.024 13.6 0.2 0.024 13.6 0.2 1.7 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 EDK39772.2 - 0.052 13.1 0.3 0.12 12.0 0.3 1.6 1 0 0 1 1 1 0 RIO1 family GPHR_N PF12537.8 EDK39772.2 - 0.76 9.9 3.8 7.5 6.7 0.4 2.9 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal RR_TM4-6 PF06459.12 EDK39772.2 - 1.8 8.3 10.3 3.9 7.2 10.3 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-NF-X1 PF01422.17 EDK39773.2 - 7.7e-06 25.9 9.3 7.7e-06 25.9 9.3 12.4 15 1 0 15 15 15 4 NF-X1 type zinc finger Fcf1 PF04900.12 EDK39774.1 - 3.5e-37 126.8 0.9 7e-37 125.8 0.9 1.5 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EDK39774.1 - 0.018 15.3 0.0 0.04 14.2 0.0 1.6 1 0 0 1 1 1 0 PIN like domain RR_TM4-6 PF06459.12 EDK39774.1 - 0.66 9.8 7.1 0.89 9.3 7.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OPT PF03169.15 EDK39775.2 - 1.9e-193 644.5 58.7 2.2e-193 644.3 58.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Iron_permease PF04120.12 EDK39775.2 - 0.16 11.7 2.2 0.2 11.5 0.7 1.9 2 0 0 2 2 2 0 Low affinity iron permease GrpE PF01025.19 EDK39776.1 - 9.1e-53 178.3 7.3 1.3e-52 177.8 7.3 1.3 1 1 0 1 1 1 1 GrpE Clusterin PF01093.17 EDK39776.1 - 0.0016 17.5 3.4 0.002 17.2 3.4 1.2 1 0 0 1 1 1 1 Clusterin DUF812 PF05667.11 EDK39776.1 - 0.031 13.2 10.1 0.039 12.8 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) PKcGMP_CC PF16808.5 EDK39776.1 - 0.032 14.1 0.6 0.071 13.0 0.6 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FAM76 PF16046.5 EDK39776.1 - 0.042 13.2 2.8 0.055 12.8 2.8 1.1 1 0 0 1 1 1 0 FAM76 protein GAS PF13851.6 EDK39776.1 - 0.071 12.4 16.9 0.17 11.2 16.9 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF5352 PF17303.2 EDK39776.1 - 0.15 11.9 0.9 0.22 11.4 0.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5352) Sec34 PF04136.15 EDK39776.1 - 0.27 11.1 5.7 0.39 10.6 4.8 1.5 1 1 0 1 1 1 0 Sec34-like family UPF0242 PF06785.11 EDK39776.1 - 0.28 11.3 11.0 0.37 10.9 11.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF740 PF05340.12 EDK39776.1 - 0.38 9.4 4.4 0.44 9.2 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) DUF3391 PF11871.8 EDK39776.1 - 0.46 11.0 9.3 0.72 10.4 9.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) DUF1796 PF08795.10 EDK39776.1 - 0.54 10.2 2.3 0.99 9.4 1.9 1.6 1 1 1 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) Prominin PF05478.11 EDK39776.1 - 0.57 8.1 3.8 0.68 7.8 3.8 1.1 1 0 0 1 1 1 0 Prominin DUF1664 PF07889.12 EDK39776.1 - 0.99 9.5 4.2 16 5.6 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3573 PF12097.8 EDK39776.1 - 1.2 7.9 4.1 1.8 7.3 4.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) V_ATPase_I PF01496.19 EDK39776.1 - 3.2 5.6 7.5 3.8 5.3 7.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OmpH PF03938.14 EDK39776.1 - 4.5 7.6 15.5 7.5 6.9 15.5 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 EDK39776.1 - 4.8 6.3 6.4 6.3 5.9 6.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein Iso_dh PF00180.20 EDK39777.1 - 2.5e-33 115.7 0.0 2.9e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 EDK39778.2 - 9.5e-60 202.6 0.0 1.2e-59 202.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pkinase PF00069.25 EDK39779.2 - 6.8e-41 140.4 0.0 9.8e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39779.2 - 1.4e-22 80.2 0.0 2.7e-22 79.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK39779.2 - 0.17 10.8 1.7 0.25 10.2 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain Methyltr_RsmB-F PF01189.17 EDK39780.2 - 3.6e-25 88.8 0.0 7e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Hist_deacetyl PF00850.19 EDK39781.2 - 3.5e-88 296.0 0.0 5.1e-88 295.5 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 EDK39781.2 - 1.5e-59 201.3 0.0 3.3e-59 200.1 0.0 1.6 1 1 0 1 1 1 1 Arb2 domain UPF0146 PF03686.13 EDK39781.2 - 0.036 13.9 0.2 3.6 7.5 0.0 2.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0146) His_Phos_1 PF00300.22 EDK39782.2 - 6.8e-12 45.5 0.2 2.1e-11 43.9 0.2 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4111 PF13427.6 EDK39782.2 - 0.16 12.2 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4111) WD40 PF00400.32 EDK39783.2 - 0.067 14.1 0.2 3.2 8.8 0.0 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat Eisosome1 PF12757.7 EDK39783.2 - 2.1 8.6 10.7 3.3 8.0 10.7 1.3 1 0 0 1 1 1 0 Eisosome protein 1 Myb_DNA-bind_7 PF15963.5 EDK39784.2 - 5.4e-27 93.5 1.2 5.4e-27 93.5 1.2 2.5 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EDK39784.2 - 1.9e-09 37.6 0.0 4.6e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PIG-H PF10181.9 EDK39785.2 - 4.1e-21 74.6 0.1 7.9e-21 73.7 0.1 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component RhoGAP PF00620.27 EDK39786.2 - 8e-34 116.7 0.4 2.3e-33 115.2 0.4 1.9 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EDK39786.2 - 1.1e-30 105.6 49.5 1e-10 41.6 6.3 4.5 4 0 0 4 4 4 4 LIM domain BssS PF13991.6 EDK39786.2 - 0.15 12.1 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 BssS protein family BolA PF01722.18 EDK39787.1 - 9.4e-18 64.3 0.0 2.2e-17 63.1 0.0 1.5 1 1 0 1 1 1 1 BolA-like protein Nit_Regul_Hom PF10126.9 EDK39787.1 - 0.17 11.9 0.0 0.34 11.0 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII MFS_1 PF07690.16 EDK39788.2 - 6.7e-25 87.8 29.2 6.7e-25 87.8 29.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDK39788.2 - 2.7e-06 26.5 12.4 2.7e-06 26.5 12.4 2.1 2 0 0 2 2 2 2 MFS_1 like family NIF3 PF01784.18 EDK39789.2 - 1.7e-57 194.8 0.0 2e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Phosphodiest PF01663.22 EDK39790.2 - 8.9e-86 288.7 4.4 9.9e-86 288.5 1.6 1.9 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDK39790.2 - 0.0049 16.3 0.1 0.15 11.4 0.0 2.3 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EDK39790.2 - 0.014 14.8 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily zf-Nse PF11789.8 EDK39791.2 - 8.5e-17 60.7 0.0 1.4e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDK39791.2 - 0.0083 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDK39791.2 - 0.0089 15.8 0.0 0.026 14.4 0.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RMF PF04957.12 EDK39791.2 - 0.066 13.4 1.2 0.088 13.0 0.1 1.8 2 0 0 2 2 2 0 Ribosome modulation factor EHN PF06441.12 EDK39791.2 - 0.17 12.2 0.5 0.32 11.4 0.5 1.4 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Methyltransf_11 PF08241.12 EDK39792.2 - 1.3e-23 83.4 0.0 2.8e-23 82.4 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK39792.2 - 4.5e-19 68.9 0.0 6.8e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK39792.2 - 2e-18 66.9 0.0 3.6e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK39792.2 - 1.5e-17 63.8 0.0 2e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK39792.2 - 2e-10 41.3 0.0 3.3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK39792.2 - 5e-09 35.8 0.0 7.4e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 EDK39792.2 - 8.7e-05 21.3 0.1 0.0003 19.5 0.0 1.7 1 1 1 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 EDK39792.2 - 0.00022 20.9 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.20 EDK39792.2 - 0.0012 18.0 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.12 EDK39792.2 - 0.0016 18.0 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PCMT PF01135.19 EDK39792.2 - 0.0025 17.6 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EDK39792.2 - 0.0026 16.7 0.0 0.0064 15.5 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) DREV PF05219.12 EDK39792.2 - 0.003 16.7 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase DOT1 PF08123.13 EDK39792.2 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 DUF3567 PF12091.8 EDK39792.2 - 0.16 12.1 0.1 13 6.0 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF3567) Methyltransf_31 PF13847.6 EDK39793.1 - 4.1e-25 88.3 0.0 5.3e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK39793.1 - 1.5e-23 83.3 0.0 4.5e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK39793.1 - 1.1e-22 80.5 0.0 2.2e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK39793.1 - 5.5e-19 68.4 0.0 1.1e-18 67.5 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDK39793.1 - 7.1e-13 48.7 0.0 8.9e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK39793.1 - 3.4e-12 47.0 0.0 1.1e-11 45.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EDK39793.1 - 3.2e-06 27.1 0.0 4.8e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EDK39793.1 - 8.6e-06 25.5 0.0 1.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EDK39793.1 - 9.5e-06 25.3 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EDK39793.1 - 2.3e-05 24.0 0.0 4.3e-05 23.1 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 EDK39793.1 - 0.00016 20.7 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_8 PF05148.15 EDK39793.1 - 0.00023 21.1 0.0 0.00089 19.2 0.0 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.20 EDK39793.1 - 0.00033 20.0 0.2 0.00071 18.9 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EDK39793.1 - 0.00035 20.1 0.1 0.0029 17.1 0.0 2.2 1 1 1 2 2 2 1 Putative methyltransferase Methyltransf_32 PF13679.6 EDK39793.1 - 0.0016 18.5 0.1 0.0037 17.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EDK39793.1 - 0.0046 16.9 0.0 0.0084 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EDK39793.1 - 0.0052 15.4 0.2 0.013 14.1 0.0 1.6 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 EDK39793.1 - 0.006 15.9 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 EDK39793.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase MFS_1 PF07690.16 EDK39794.2 - 4.5e-38 131.1 32.8 4.5e-38 131.1 32.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDK39794.2 - 0.001 17.5 2.9 0.001 17.5 2.9 2.0 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family PsbM PF05151.12 EDK39794.2 - 0.11 12.3 4.3 0.21 11.4 1.8 2.7 2 0 0 2 2 2 0 Photosystem II reaction centre M protein (PsbM) Zn_clus PF00172.18 EDK39795.2 - 3e-09 36.8 12.6 3e-09 36.8 12.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2614 PF11023.8 EDK39795.2 - 0.39 10.8 8.0 1.9 8.6 0.7 2.5 2 0 0 2 2 2 0 Zinc-ribbon containing domain GCR1_C PF12550.8 EDK39796.2 - 0.0049 17.2 0.4 0.016 15.5 0.4 1.9 1 1 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Herpes_DNAp_acc PF04929.12 EDK39796.2 - 1.8 7.4 14.5 0.14 11.1 9.7 1.5 2 0 0 2 2 2 0 Herpes DNA replication accessory factor ELFV_dehydrog PF00208.21 EDK39797.1 - 1e-85 287.4 5.5 1.2e-85 287.1 5.5 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EDK39797.1 - 1.2e-49 167.5 0.0 3e-49 166.2 0.0 1.7 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Tim54 PF11711.8 EDK39798.2 - 2.1e-137 457.9 1.6 2.5e-137 457.7 1.6 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 HD_2 PF12917.7 EDK39798.2 - 0.017 14.9 0.7 0.027 14.2 0.1 1.6 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme cobW PF02492.19 EDK39799.2 - 3.5e-43 147.3 0.9 4.6e-43 146.8 0.9 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EDK39799.2 - 3.7e-07 30.0 0.1 1.5e-06 28.1 0.1 2.1 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EDK39799.2 - 0.00037 20.4 0.2 0.49 10.3 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDK39799.2 - 0.0032 17.2 0.0 0.0091 15.7 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EDK39799.2 - 0.01 15.9 0.0 0.026 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDK39799.2 - 0.017 15.7 0.6 0.034 14.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDK39799.2 - 0.02 15.5 0.1 0.056 14.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDK39799.2 - 0.025 15.0 0.0 0.059 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EDK39799.2 - 0.026 14.6 0.0 0.075 13.1 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK39799.2 - 0.053 13.1 0.1 4.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Viral_helicase1 PF01443.18 EDK39799.2 - 0.074 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EDK39799.2 - 0.093 13.0 0.1 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDK39799.2 - 0.11 13.1 0.3 0.3 11.6 0.1 1.8 2 0 0 2 2 2 0 ABC transporter Glyco_transf_22 PF03901.17 EDK39800.2 - 3.4e-35 122.1 21.1 5.3e-35 121.4 21.1 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CCB1 PF12046.8 EDK39800.2 - 5.3 6.4 7.4 1.8 7.9 0.0 3.5 3 1 1 4 4 4 0 Cofactor assembly of complex C subunit B Sfi1 PF08457.10 EDK39801.2 - 5.8e-26 91.2 76.2 1.5e-22 79.9 55.9 2.6 2 1 1 3 3 3 2 Sfi1 spindle body protein Pkinase PF00069.25 EDK39802.2 - 3.6e-67 226.5 0.0 6e-67 225.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK39802.2 - 5.2e-44 150.5 0.0 1e-43 149.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK39802.2 - 7.2e-11 41.9 0.0 4e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_1 PF00536.30 EDK39802.2 - 0.00096 19.6 0.0 0.0063 16.9 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EDK39802.2 - 0.028 13.2 0.1 0.084 11.6 0.1 1.7 1 0 0 1 1 1 0 Fungal protein kinase GHL13 PF14883.6 EDK39802.2 - 0.083 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 Ribosomal_L21p PF00829.21 EDK39803.2 - 1.6e-11 44.4 0.0 2.1e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein UPF0640 PF15114.6 EDK39803.2 - 0.084 12.7 0.6 0.42 10.4 0.3 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0640 SAPS PF04499.15 EDK39804.2 - 1.3e-191 637.7 4.9 1.3e-191 637.7 4.9 2.8 3 0 0 3 3 3 2 SIT4 phosphatase-associated protein TAF4 PF05236.14 EDK39804.2 - 0.21 11.3 8.9 0.04 13.7 5.2 1.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Tim54 PF11711.8 EDK39804.2 - 0.26 10.0 4.3 0.12 11.2 1.8 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 EDK39804.2 - 1.2 9.3 9.0 1.2 9.3 5.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1687 PF07955.11 EDK39805.2 - 2.6e-19 70.0 0.0 3.8e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) GATase_4 PF13230.6 EDK39806.2 - 3.6e-14 52.3 0.1 1.2e-13 50.6 0.1 1.7 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EDK39806.2 - 2e-11 44.3 0.0 3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Isochorismatase PF00857.20 EDK39807.1 - 7.1e-37 127.3 0.1 7.7e-37 127.1 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family PyrI_C PF02748.15 EDK39808.1 - 0.0089 15.9 0.2 0.024 14.5 0.2 1.8 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain PRD1_DD PF11087.8 EDK39808.1 - 0.35 10.6 3.2 4.5 7.0 0.2 3.1 2 1 1 3 3 3 0 PRD1 phage membrane DNA delivery DUF3304 PF11745.8 EDK39808.1 - 3.3 8.2 5.9 19 5.7 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3304) YabA PF06156.13 EDK39809.2 - 0.027 15.1 0.3 0.043 14.5 0.3 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Synaphin PF05835.12 EDK39809.2 - 0.082 13.2 4.0 0.12 12.7 4.0 1.2 1 0 0 1 1 1 0 Synaphin protein ZapB PF06005.12 EDK39809.2 - 0.094 13.2 10.3 0.25 11.8 10.2 1.7 1 1 0 1 1 1 0 Cell division protein ZapB Med21 PF11221.8 EDK39809.2 - 2.7 8.2 7.3 5 7.4 6.8 1.6 1 1 0 1 1 1 0 Subunit 21 of Mediator complex PTPLA PF04387.14 EDK39810.2 - 3e-42 144.2 11.0 5.6e-42 143.3 11.0 1.5 1 1 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA PTPLA PF04387.14 EDK39811.1 - 2e-57 193.5 8.9 3.1e-57 192.9 8.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ChAPs PF09295.10 EDK39812.2 - 9.1e-26 90.8 0.0 3.7e-21 75.6 0.0 2.4 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 EDK39812.2 - 0.0087 16.3 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EDK39812.2 - 0.019 15.5 0.0 0.04 14.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat PP2C PF00481.21 EDK39813.2 - 1.7e-43 149.2 0.0 2.7e-43 148.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EDK39813.2 - 3.1e-42 142.2 72.1 3.5e-09 36.3 7.3 9.5 3 2 6 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 EDK39813.2 - 1.4e-32 111.2 84.2 3.6e-06 27.2 4.0 12.6 5 3 8 14 14 14 12 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EDK39813.2 - 1.7e-28 99.5 0.0 3.3e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 EDK39813.2 - 7.3e-06 25.6 26.5 0.0039 16.7 1.6 5.8 2 1 3 6 6 6 3 Leucine-rich repeat LRR_1 PF00560.33 EDK39813.2 - 5.4e-05 23.2 62.1 0.82 10.5 0.2 16.5 16 1 1 17 17 17 2 Leucine Rich Repeat LRR_5 PF13306.6 EDK39813.2 - 0.067 13.2 15.7 0.43 10.5 0.3 5.0 4 2 2 6 6 6 0 BspA type Leucine rich repeat region (6 copies) Ad_cyc_g-alpha PF08509.11 EDK39814.2 - 0.019 14.7 0.8 0.039 13.7 0.8 1.5 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain Presenilin PF01080.17 EDK39814.2 - 0.15 10.8 1.7 0.23 10.2 1.7 1.2 1 0 0 1 1 1 0 Presenilin Pneumo_att_G PF05539.11 EDK39814.2 - 1.5 8.3 7.6 2.2 7.8 7.6 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G PH_12 PF16457.5 EDK39815.2 - 8.2e-33 113.8 0.0 1.9e-32 112.6 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DEAD PF00270.29 EDK39816.2 - 1.4e-45 155.2 0.1 3.1e-45 154.1 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39816.2 - 7.9e-28 97.0 2.4 1.7e-27 95.9 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain SYS1 PF09801.9 EDK39817.2 - 1.3e-52 177.8 16.5 1.5e-52 177.6 16.5 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Glyco_hydro_3_C PF01915.22 EDK39818.2 - 2.7e-63 213.6 0.0 4.5e-63 212.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDK39818.2 - 8.8e-46 156.7 0.0 1.4e-45 156.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EDK39818.2 - 1.2e-23 83.0 0.5 3.1e-23 81.7 0.2 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 EDK39818.2 - 4.4e-17 62.2 0.1 9.8e-17 61.1 0.1 1.5 1 0 0 1 1 1 1 PA14 domain Aldolase_II PF00596.21 EDK39819.1 - 2.9e-49 167.5 1.1 3.8e-49 167.2 1.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TetR_N PF00440.23 EDK39819.1 - 0.46 10.3 4.0 3.5 7.5 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family AA_permease PF00324.21 EDK39820.2 - 3.9e-113 378.6 44.5 4.6e-113 378.4 44.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK39820.2 - 1.4e-23 83.4 46.8 2e-23 83.0 46.8 1.0 1 0 0 1 1 1 1 Amino acid permease FMN_dh PF01070.18 EDK39821.2 - 1.9e-63 214.6 0.1 2.8e-63 214.1 0.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EDK39821.2 - 7.2e-10 38.5 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDK39821.2 - 1.1e-06 28.0 0.2 8.7e-05 21.7 0.1 2.3 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EDK39821.2 - 0.0028 17.1 0.6 0.0073 15.7 0.5 1.7 1 1 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EDK39821.2 - 0.024 14.1 0.3 1 8.8 0.0 2.4 2 1 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.14 EDK39821.2 - 0.043 13.1 0.0 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EDK39821.2 - 0.14 11.6 0.3 18 4.7 0.0 2.8 2 1 1 3 3 3 0 Glycerol-3-phosphate responsive antiterminator FMN_dh PF01070.18 EDK39822.2 - 4.4e-24 85.1 0.0 5.9e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDK39822.2 - 2.2e-21 75.8 0.1 1.1e-20 73.5 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Aminotran_3 PF00202.21 EDK39823.1 - 2.4e-63 214.2 0.0 2.9e-63 213.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Ribonuc_L-PSP PF01042.21 EDK39824.2 - 7.7e-24 84.0 0.1 9.3e-24 83.8 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP MoCF_biosynth PF00994.24 EDK39824.2 - 0.06 13.0 0.0 0.064 12.9 0.0 1.1 1 0 0 1 1 1 0 Probable molybdopterin binding domain Epimerase PF01370.21 EDK39825.1 - 4e-18 65.8 0.0 5.3e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK39825.1 - 1.1e-16 60.7 0.0 1.6e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK39825.1 - 4.6e-10 39.1 0.1 0.00033 19.9 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK39825.1 - 8.4e-10 38.6 0.0 2.8e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDK39825.1 - 2.1e-05 24.1 0.0 3.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EDK39825.1 - 0.00051 19.3 0.2 0.00093 18.4 0.2 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDK39825.1 - 0.00055 19.9 0.0 0.0014 18.6 0.0 1.7 2 1 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EDK39825.1 - 0.0025 17.8 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EDK39825.1 - 0.023 14.7 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Zeta_toxin PF06414.12 EDK39825.1 - 0.034 13.4 0.0 0.056 12.7 0.0 1.4 1 1 0 1 1 1 0 Zeta toxin NmrA PF05368.13 EDK39825.1 - 0.038 13.5 0.0 0.096 12.2 0.0 1.7 2 0 0 2 2 2 0 NmrA-like family adh_short_C2 PF13561.6 EDK39825.1 - 0.097 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Fungal_trans_2 PF11951.8 EDK39826.2 - 1.7e-68 231.2 6.8 2e-68 231.0 6.8 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_1_2 PF00155.21 EDK39827.2 - 2.6e-39 135.4 0.0 4e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Fungal_trans PF04082.18 EDK39828.2 - 8e-20 71.0 2.0 1.4e-19 70.2 2.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39828.2 - 0.0011 19.0 6.8 0.0021 18.1 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PKcGMP_CC PF16808.5 EDK39828.2 - 0.64 9.9 3.8 4.5 7.2 1.1 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Lyase_1 PF00206.20 EDK39829.2 - 1.4e-46 159.4 0.0 2.2e-46 158.7 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EDK39829.2 - 5.4e-17 62.1 0.0 1.2e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Sugar_tr PF00083.24 EDK39830.2 - 8.6e-45 153.4 22.7 9.7e-45 153.3 22.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39830.2 - 1.7e-05 23.9 17.1 2.2e-05 23.6 17.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ABC2_membrane_2 PF12679.7 EDK39830.2 - 1.6 8.0 7.8 2.6 7.3 7.3 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein MFS_1 PF07690.16 EDK39831.1 - 2.4e-05 23.4 15.7 2.9e-05 23.2 15.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1980 PF09323.10 EDK39831.1 - 2.2 8.2 4.3 1 9.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) adh_short PF00106.25 EDK39832.1 - 6.1e-14 51.9 0.0 7.6e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK39832.1 - 8.1e-12 45.2 0.0 1e-11 44.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK39832.1 - 1.7e-07 31.3 0.0 2.1e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK39832.1 - 0.0053 16.7 0.0 0.0064 16.4 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK39832.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family CRAL_TRIO_2 PF13716.6 EDK39833.2 - 0.01 16.0 0.4 0.13 12.5 0.2 2.3 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain Zn_clus PF00172.18 EDK39834.2 - 5.9e-06 26.3 12.1 5.9e-06 26.3 12.1 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Serglycin PF04360.12 EDK39834.2 - 0.068 13.1 0.1 0.17 11.9 0.2 1.6 2 0 0 2 2 2 0 Serglycin DUF1479 PF07350.12 EDK39835.2 - 4.5e-159 529.7 0.0 5.6e-159 529.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) TauD PF02668.16 EDK39835.2 - 0.093 12.5 0.0 0.62 9.8 0.0 2.0 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans PF04082.18 EDK39836.2 - 1.2e-10 40.9 0.3 2.6e-10 39.8 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EDK39837.2 - 2.4e-72 244.2 26.3 3.2e-72 243.8 26.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39837.2 - 7e-22 77.8 16.6 7e-22 77.8 16.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SPP PF06550.11 EDK39837.2 - 0.00058 19.4 1.8 0.00058 19.4 0.4 1.7 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease MFS_1_like PF12832.7 EDK39837.2 - 0.016 14.1 11.5 0.059 12.2 2.6 2.9 2 2 1 3 3 3 0 MFS_1 like family DUF1593 PF07632.11 EDK39838.2 - 9.3e-83 277.6 0.0 1.3e-82 277.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EDK39838.2 - 0.039 12.7 0.0 0.069 11.9 0.0 1.4 1 1 0 1 1 1 0 REJ domain Zn_clus PF00172.18 EDK39840.2 - 0.0063 16.6 11.6 0.013 15.6 11.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ApoLp-III PF07464.11 EDK39840.2 - 0.11 12.6 0.0 0.39 10.8 0.0 1.9 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) M20_dimer PF07687.14 EDK39841.2 - 9.7e-07 28.7 0.0 8.2e-06 25.7 0.0 2.2 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EDK39841.2 - 5.3e-06 26.3 0.0 8.8e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4950 PF16308.5 EDK39841.2 - 0.08 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4950) MFS_1 PF07690.16 EDK39842.2 - 1.8e-37 129.1 32.3 1.8e-37 129.1 32.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily ATG22 PF11700.8 EDK39842.2 - 3.8e-06 25.8 6.2 3.8e-06 25.8 6.2 1.8 1 1 1 2 2 2 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EDK39843.2 - 2.8e-07 29.8 45.7 9.1e-05 21.5 45.2 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily SLC3A2_N PF16028.5 EDK39843.2 - 0.00016 21.2 0.2 0.0011 18.5 0.0 2.5 2 0 0 2 2 2 1 Solute carrier family 3 member 2 N-terminus Sugar_tr PF00083.24 EDK39843.2 - 0.00066 18.7 17.8 0.00066 18.7 17.8 2.6 1 1 0 2 2 2 1 Sugar (and other) transporter LRR_4 PF12799.7 EDK39844.2 - 1.2e-10 41.4 37.5 0.00067 20.0 1.0 9.2 4 2 7 11 11 11 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK39844.2 - 1.7e-09 37.3 32.2 2e-06 27.5 2.0 7.3 4 2 4 8 8 8 5 Leucine rich repeat LRR_9 PF14580.6 EDK39844.2 - 4.5e-05 23.0 1.6 0.16 11.5 0.1 3.4 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EDK39844.2 - 0.0011 18.8 10.2 1.1e+02 3.2 0.0 9.0 10 0 0 10 10 10 0 Leucine Rich repeat Zn_clus PF00172.18 EDK39845.2 - 7.8e-07 29.1 12.1 7.8e-07 29.1 12.1 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HOK_GEF PF01848.16 EDK39845.2 - 0.15 11.5 0.1 0.8 9.2 0.0 2.0 2 0 0 2 2 2 0 Hok/gef family DUF2961 PF11175.8 EDK39846.1 - 3e-82 275.8 5.6 4.3e-82 275.3 5.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) Sugar_tr PF00083.24 EDK39847.2 - 4.5e-81 273.0 27.3 5.2e-81 272.8 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39847.2 - 5.8e-19 68.2 58.2 2.4e-17 62.9 32.1 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK39847.2 - 0.00019 20.2 18.1 0.0025 16.4 7.3 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein EamA PF00892.20 EDK39847.2 - 0.0091 16.2 3.8 0.0091 16.2 3.8 3.6 3 1 0 3 3 3 1 EamA-like transporter family MFS_1 PF07690.16 EDK39849.2 - 1.1e-26 93.7 23.8 1.1e-26 93.7 23.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2975 PF11188.8 EDK39849.2 - 5.3 6.9 7.1 0.52 10.2 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2975) DUF1485 PF07364.12 EDK39850.2 - 7.6e-61 205.9 0.0 9.8e-61 205.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M81 MlrC_C PF07171.12 EDK39850.2 - 1.6e-40 139.2 0.0 2.4e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 MlrC C-terminus Fungal_trans PF04082.18 EDK39851.2 - 1.7e-25 89.6 6.1 2.1e-24 86.0 2.5 3.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39851.2 - 9.9e-06 25.6 17.7 1.6e-05 24.9 17.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 EDK39851.2 - 8.5 6.8 8.7 20 5.6 8.7 1.6 1 0 0 1 1 1 0 Opy2 protein FMO-like PF00743.19 EDK39852.2 - 2.2e-38 132.0 0.1 8.7e-26 90.4 0.0 2.7 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDK39852.2 - 9.1e-21 74.4 0.4 7.7e-19 68.1 0.4 2.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK39852.2 - 6.4e-15 55.5 0.0 3.1e-13 50.0 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EDK39852.2 - 2.4e-13 50.0 0.1 3e-12 46.4 0.1 2.6 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK39852.2 - 3.8e-08 33.3 0.1 0.0056 16.3 0.0 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EDK39852.2 - 1.2e-07 30.8 0.3 3.6e-05 22.7 0.0 2.9 2 1 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EDK39852.2 - 2.2e-07 31.0 0.1 1.6e-06 28.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDK39852.2 - 1e-06 29.2 0.1 0.87 10.2 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EDK39852.2 - 0.00011 21.7 0.0 0.0038 16.6 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 EDK39852.2 - 0.00033 19.6 0.0 0.4 9.5 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase K_oxygenase PF13434.6 EDK39852.2 - 0.00082 18.6 0.1 0.0038 16.4 0.0 2.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EDK39852.2 - 0.0019 17.6 0.2 0.54 9.5 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EDK39852.2 - 0.043 13.1 0.2 0.51 9.5 0.0 2.1 2 0 0 2 2 2 0 Thi4 family PATR PF12951.7 EDK39852.2 - 0.076 13.1 2.7 0.15 12.2 2.7 1.5 1 0 0 1 1 1 0 Passenger-associated-transport-repeat FAD_binding_2 PF00890.24 EDK39852.2 - 0.25 10.4 0.3 5.7 5.9 0.0 2.5 3 0 0 3 3 3 0 FAD binding domain GIDA PF01134.22 EDK39852.2 - 0.4 9.7 5.0 4 6.4 0.9 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EDK39852.2 - 0.73 9.0 3.1 0.4 9.9 0.7 1.7 2 0 0 2 2 2 0 FAD binding domain Sugar_tr PF00083.24 EDK39853.2 - 5.7e-81 272.7 26.8 6.5e-81 272.5 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39853.2 - 6.6e-20 71.3 59.3 1.7e-18 66.7 32.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK39853.2 - 0.00012 20.8 21.4 0.01 14.5 9.3 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein EamA PF00892.20 EDK39853.2 - 0.0082 16.3 3.8 0.0082 16.3 3.8 3.7 3 1 1 4 4 4 1 EamA-like transporter family DUF543 PF04418.12 EDK39853.2 - 0.26 11.3 1.1 1.8 8.6 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) DUF2961 PF11175.8 EDK39854.1 - 3.1e-82 275.8 5.6 4.4e-82 275.3 5.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) hNIFK_binding PF12196.8 EDK39854.1 - 0.16 11.5 1.1 0.51 9.9 1.1 1.8 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Fungal_trans PF04082.18 EDK39855.2 - 1.5e-08 34.0 0.7 2.5e-08 33.3 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain LRR_4 PF12799.7 EDK39856.2 - 2.1e-05 24.8 42.1 0.03 14.7 0.3 10.6 8 3 3 11 11 11 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK39856.2 - 0.00051 19.7 27.3 0.21 11.3 1.5 8.1 3 1 7 10 10 10 6 Leucine rich repeat FNIP PF05725.12 EDK39856.2 - 0.018 15.2 30.6 0.27 11.4 0.2 8.0 7 1 0 7 7 7 0 FNIP Repeat LRR_5 PF13306.6 EDK39856.2 - 0.13 12.2 6.5 0.75 9.8 0.0 4.2 4 1 0 4 4 4 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EDK39856.2 - 8.6 6.7 17.6 21 5.5 0.1 7.5 8 0 0 8 8 8 0 Leucine Rich repeat HTH_AraC PF00165.23 EDK39857.2 - 1.2e-05 25.2 0.0 4.3e-05 23.5 0.0 2.0 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EDK39857.2 - 0.00013 22.2 0.0 0.00025 21.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain LRR_4 PF12799.7 EDK39858.2 - 5e-17 61.7 34.3 0.00017 21.9 0.0 9.5 8 3 2 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK39858.2 - 1.3e-15 56.9 30.2 1.3e-10 40.9 2.3 7.5 5 3 4 9 9 9 4 Leucine rich repeat LRR_6 PF13516.6 EDK39858.2 - 0.00045 20.0 17.7 39 4.6 0.0 11.0 12 0 0 12 12 12 0 Leucine Rich repeat FNIP PF05725.12 EDK39858.2 - 0.04 14.1 0.4 0.04 14.1 0.4 6.2 7 2 1 8 8 8 0 FNIP Repeat LRR_9 PF14580.6 EDK39858.2 - 0.13 11.7 3.4 8.3 5.9 0.7 3.6 2 1 0 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.33 EDK39858.2 - 0.25 12.0 31.1 25 6.0 0.0 9.9 7 3 0 7 7 7 0 Leucine Rich Repeat Asp PF00026.23 EDK39859.2 - 1.2e-70 238.5 12.6 1.4e-70 238.2 12.6 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK39859.2 - 2.5e-10 40.9 8.1 1.9e-08 34.7 8.1 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDK39859.2 - 0.058 13.2 0.1 10 5.9 0.0 2.4 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Asp PF00026.23 EDK39860.2 - 1.6e-63 215.1 2.1 2e-63 214.7 2.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK39860.2 - 6.2e-09 36.3 1.8 0.00026 21.3 0.7 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDK39860.2 - 0.016 15.0 0.0 1.1 9.0 0.0 2.7 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Asp PF00026.23 EDK39861.2 - 2.2e-65 221.2 1.3 2.8e-65 220.8 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK39861.2 - 4.9e-10 39.9 1.7 1.9e-07 31.5 1.7 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDK39861.2 - 0.0098 15.7 0.0 0.033 14.0 0.0 1.7 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EDK39861.2 - 0.12 13.0 0.5 11 6.8 0.0 3.4 2 2 1 3 3 3 0 Aspartyl protease DUF1772 PF08592.11 EDK39862.2 - 4.3e-13 49.8 4.4 5.4e-13 49.4 4.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) KRTDAP PF15200.6 EDK39863.2 - 0.058 13.2 0.3 0.18 11.6 0.3 1.8 1 0 0 1 1 1 0 Keratinocyte differentiation-associated FSA_C PF10479.9 EDK39863.2 - 1.2 7.2 10.6 1.8 6.6 10.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PAP1 PF08601.10 EDK39863.2 - 3.6 7.2 6.7 5 6.8 6.7 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 FMO-like PF00743.19 EDK39864.2 - 1.1e-32 113.2 0.1 2.7e-13 49.2 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDK39864.2 - 2.4e-11 43.4 0.1 5.2e-09 35.8 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EDK39864.2 - 5.4e-07 29.1 0.0 5.9e-06 25.7 0.0 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK39864.2 - 9.7e-07 28.2 0.3 5.4e-05 22.5 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDK39864.2 - 1.5e-06 28.3 0.0 6e-05 23.1 0.0 3.1 5 0 0 5 5 5 1 FAD-NAD(P)-binding Thi4 PF01946.17 EDK39864.2 - 2.9e-05 23.4 0.2 0.011 15.0 0.1 2.3 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 EDK39864.2 - 3.2e-05 24.1 0.0 0.0001 22.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDK39864.2 - 0.018 14.6 0.0 0.85 9.1 0.1 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDK39864.2 - 0.11 13.0 0.3 37 5.0 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GATase PF00117.28 EDK39865.2 - 7.2e-11 42.2 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EDK39865.2 - 0.051 13.2 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EDK39865.2 - 0.089 12.5 0.1 0.19 11.5 0.1 1.7 1 1 0 1 1 1 0 Peptidase C26 SLATT_5 PF18160.1 EDK39866.2 - 0.14 11.5 1.0 0.22 10.8 1.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 PriC PF07445.12 EDK39866.2 - 2.3 8.1 9.1 3.9 7.4 0.8 2.4 2 0 0 2 2 2 0 Primosomal replication protein priC zf-Tim10_DDP PF02953.15 EDK39867.1 - 5.3e-18 64.4 2.4 6.9e-18 64.1 2.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tti2 PF10521.9 EDK39868.2 - 6e-53 180.2 0.2 7.7e-53 179.8 0.2 1.1 1 0 0 1 1 1 1 Tti2 family Indigoidine_A PF04227.12 EDK39869.2 - 7.6e-116 386.5 0.1 8.6e-116 386.4 0.1 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EDK39870.2 - 0.0066 15.8 0.0 0.19 11.0 0.0 2.7 3 0 0 3 3 3 1 pfkB family carbohydrate kinase Chalcone_2 PF16035.5 EDK39871.2 - 4.9e-57 193.0 0.2 1.7e-56 191.2 0.2 1.7 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EDK39871.2 - 0.0058 16.8 0.0 0.16 12.1 0.1 2.1 2 0 0 2 2 2 1 Chalcone isomerase-like NTP_transferase PF00483.23 EDK39872.1 - 1e-53 182.5 0.0 1.5e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDK39872.1 - 9.4e-15 53.7 5.6 2.5e-08 33.3 0.3 4.2 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EDK39872.1 - 7.2e-11 42.7 0.0 1e-10 42.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EDK39872.1 - 0.00079 19.1 0.7 0.35 10.7 0.1 3.1 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase MFS_1 PF07690.16 EDK39874.2 - 3.6e-15 55.7 21.1 3.6e-15 55.7 21.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EDK39874.2 - 5e-06 26.2 10.3 5e-06 26.2 10.3 2.2 2 0 0 2 2 2 1 Nodulin-like FBPase PF00316.20 EDK39875.2 - 3e-80 268.2 0.3 3.9e-80 267.8 0.3 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EDK39875.2 - 0.013 15.0 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Inositol monophosphatase family Tic110 PF16940.5 EDK39876.2 - 0.14 10.6 1.9 0.16 10.4 1.9 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter SecY PF00344.20 EDK39877.2 - 6.7e-68 229.2 6.0 8.6e-68 228.8 6.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDK39877.2 - 9.9e-17 60.5 0.1 3.3e-16 58.8 0.1 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2975 PF11188.8 EDK39877.2 - 1.9 8.4 5.3 1.3 8.9 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) LicD PF04991.13 EDK39878.2 - 3.4e-25 89.5 1.0 1.3e-19 71.2 0.3 3.5 3 2 1 4 4 4 2 LicD family LicD PF04991.13 EDK39879.2 - 6.7e-21 75.5 4.6 5.4e-18 66.0 1.9 4.3 4 1 1 5 5 5 2 LicD family Mgm101p PF06420.12 EDK39880.2 - 2.3e-85 284.3 0.0 3.5e-85 283.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Tim17 PF02466.19 EDK39881.1 - 0.043 14.2 0.2 0.06 13.7 0.2 1.4 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family MAS20 PF02064.15 EDK39882.2 - 1.2e-41 141.8 2.8 1.5e-41 141.5 2.8 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor Nucleolin_bd PF16725.5 EDK39882.2 - 0.033 13.8 0.5 0.083 12.6 0.5 1.7 1 0 0 1 1 1 0 Nucleolin binding domain PI3K_p85B PF02192.16 EDK39882.2 - 0.043 13.6 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 PI3-kinase family, p85-binding domain Cellulase PF00150.18 EDK39883.2 - 3.9e-14 52.8 7.7 3.9e-14 52.8 7.7 2.0 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EDK39883.2 - 0.00057 19.3 3.0 0.003 17.0 0.0 2.3 2 1 0 2 2 2 1 Beta-galactosidase Glyco_hydro_10 PF00331.20 EDK39883.2 - 0.047 12.8 2.6 0.22 10.6 0.0 2.7 3 0 0 3 3 3 0 Glycosyl hydrolase family 10 Homoserine_dh PF00742.19 EDK39884.2 - 8.6e-52 175.5 0.0 1.3e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EDK39884.2 - 5.5e-21 75.4 0.0 8.5e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Hydrolase_6 PF13344.6 EDK39884.2 - 0.098 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase GFO_IDH_MocA PF01408.22 EDK39884.2 - 0.1 13.4 0.0 0.19 12.5 0.0 1.6 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold 2-Hacid_dh_C PF02826.19 EDK39884.2 - 0.11 11.8 0.0 0.27 10.6 0.0 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IML1 PF12257.8 EDK39885.2 - 3.8e-103 344.5 0.2 5.6e-103 344.0 0.2 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EDK39885.2 - 5.5e-26 90.4 0.1 1.2e-25 89.3 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SNO PF01174.19 EDK39886.1 - 3.4e-63 212.9 0.0 1.2e-61 207.8 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EDK39886.1 - 1.7e-11 44.1 0.0 2e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EDK39886.1 - 7.7e-05 22.6 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EDK39886.1 - 0.00042 20.0 0.0 0.00071 19.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S51 DUF4154 PF13689.6 EDK39886.1 - 0.062 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 YfiR/HmsC-like BPL_N PF09825.9 EDK39886.1 - 0.086 11.9 0.0 0.5 9.4 0.0 1.9 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal SOR_SNZ PF01680.17 EDK39887.1 - 6.4e-105 349.5 8.3 8.4e-105 349.1 8.3 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EDK39887.1 - 6.1e-10 38.8 5.5 9.9e-09 34.9 0.2 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDK39887.1 - 1.2e-05 24.5 0.1 0.0088 15.2 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.14 EDK39887.1 - 7e-05 22.1 1.2 0.00093 18.4 0.1 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EDK39887.1 - 0.023 14.2 0.2 0.3 10.5 0.0 2.4 2 1 0 2 2 2 0 Histidine biosynthesis protein Ribosomal_S5_C PF03719.15 EDK39887.1 - 0.039 13.4 0.0 0.093 12.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain NMO PF03060.15 EDK39887.1 - 0.048 13.0 2.8 1.2 8.5 0.2 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase IGPS PF00218.21 EDK39887.1 - 0.05 12.8 0.1 0.23 10.6 0.0 2.0 3 0 0 3 3 3 0 Indole-3-glycerol phosphate synthase TetR_C_27 PF17935.1 EDK39887.1 - 0.063 13.3 0.0 0.53 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Milton PF12448.8 EDK39887.1 - 0.12 12.5 0.0 0.58 10.2 0.0 2.0 1 1 1 2 2 2 0 Kinesin associated protein Peroxin-22 PF12827.7 EDK39888.2 - 1.1e-33 115.5 0.4 1.4e-33 115.1 0.4 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family DUF1836 PF08876.11 EDK39888.2 - 0.039 14.0 3.2 0.17 12.0 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1836) RasGEF PF00617.19 EDK39889.2 - 1.6e-49 168.5 1.8 3.9e-49 167.2 1.8 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDK39889.2 - 3.7e-18 65.7 3.4 7.5e-18 64.7 1.2 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif Reo_sigma1 PF01664.16 EDK39889.2 - 0.049 12.9 0.1 0.13 11.5 0.1 1.7 1 0 0 1 1 1 0 Reovirus viral attachment protein sigma 1 Forkhead PF00250.18 EDK39890.2 - 3.3e-18 65.7 0.1 7.2e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDK39890.2 - 4.6e-10 39.7 0.3 9.8e-10 38.7 0.3 1.6 1 0 0 1 1 1 1 FHA domain DUF1727 PF08353.10 EDK39890.2 - 0.046 13.7 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1727) FHA_2 PF17913.1 EDK39890.2 - 0.083 13.1 0.0 0.28 11.5 0.0 2.0 1 0 0 1 1 1 0 FHA domain Proteasome PF00227.26 EDK39891.1 - 1.2e-45 155.3 0.2 1.7e-45 154.9 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_L5_C PF00673.21 EDK39892.1 - 2.6e-21 75.6 0.0 4e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDK39892.1 - 2.1e-20 72.8 0.2 6.2e-20 71.3 0.0 1.9 3 0 0 3 3 3 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 EDK39892.1 - 0.065 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain BCAS2 PF05700.11 EDK39893.2 - 1.4e-19 70.7 12.4 3.3e-11 43.3 0.8 2.0 1 1 1 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) NfI_DNAbd_pre-N PF10524.9 EDK39893.2 - 0.28 11.1 1.9 8.6 6.3 0.0 2.8 3 0 0 3 3 3 0 Nuclear factor I protein pre-N-terminus Qua1 PF16274.5 EDK39893.2 - 0.36 10.7 1.6 0.81 9.6 0.8 2.0 2 1 0 2 2 2 0 Qua1 domain PHF5 PF03660.14 EDK39894.2 - 6.1e-47 158.1 12.0 7.1e-47 157.9 12.0 1.0 1 0 0 1 1 1 1 PHF5-like protein zf-ribbon_3 PF13248.6 EDK39894.2 - 0.0031 16.8 1.2 0.0031 16.8 1.2 3.2 3 0 0 3 3 3 1 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EDK39894.2 - 0.0044 17.0 5.0 0.0044 17.0 5.0 2.1 1 1 1 2 2 2 1 zinc-ribbons DZR PF12773.7 EDK39894.2 - 1.9 8.6 13.9 3.8 7.6 7.7 2.9 1 1 1 2 2 2 0 Double zinc ribbon PolC_DP2 PF03833.13 EDK39894.2 - 3.9 5.2 5.8 4.1 5.1 5.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 UPF0547 PF10571.9 EDK39894.2 - 5.7 7.1 10.3 0.36 10.9 3.8 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_2 PF13639.6 EDK39895.2 - 5.3e-10 39.5 27.8 1e-09 38.5 12.2 2.4 2 0 0 2 2 2 2 Ring finger domain PHD PF00628.29 EDK39895.2 - 3.1e-07 30.2 6.0 3.1e-07 30.2 6.0 2.6 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.7 EDK39895.2 - 0.00023 21.4 14.0 0.00023 21.4 14.0 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDK39895.2 - 0.00025 20.8 11.1 0.00025 20.8 11.1 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDK39895.2 - 0.00032 20.4 5.8 0.00032 20.4 5.8 2.8 2 1 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EDK39895.2 - 0.00045 20.2 6.1 0.00045 20.2 6.1 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-PHD-like PF15446.6 EDK39895.2 - 0.0083 15.8 1.0 0.0083 15.8 1.0 2.5 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain FANCL_C PF11793.8 EDK39895.2 - 0.012 15.7 12.4 0.5 10.6 4.7 2.9 3 0 0 3 3 3 0 FANCL C-terminal domain PHD_2 PF13831.6 EDK39895.2 - 0.023 14.2 1.7 0.023 14.2 1.7 2.5 3 0 0 3 3 3 0 PHD-finger zf-C3HC4 PF00097.25 EDK39895.2 - 0.026 14.4 10.9 0.026 14.4 10.9 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cofilin_ADF PF00241.20 EDK39896.2 - 3e-31 107.7 0.1 7.4e-16 58.0 0.1 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF498 PF04430.14 EDK39897.1 - 6e-17 61.7 0.0 8.7e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Pil1 PF13805.6 EDK39899.2 - 8.1e-126 418.9 0.1 9.6e-126 418.7 0.1 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.11 EDK39899.2 - 0.035 13.5 0.7 0.053 12.9 0.7 1.2 1 0 0 1 1 1 0 FAM92 protein APG6_N PF17675.1 EDK39899.2 - 0.77 10.3 4.4 35 4.9 0.0 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region Nop10p PF04135.12 EDK39899.2 - 1.9 8.6 3.5 14 5.8 0.2 2.3 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family Mpv17_PMP22 PF04117.12 EDK39900.2 - 2.5e-20 72.5 4.9 2.5e-20 72.5 4.9 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family Mpv17_PMP22 PF04117.12 EDK39901.1 - 2.5e-22 78.9 4.8 4.3e-22 78.1 4.8 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family B56 PF01603.20 EDK39902.2 - 3.7e-174 579.6 10.9 5.7e-163 542.7 7.8 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EDK39902.2 - 0.13 12.2 2.1 5.6 6.9 0.2 2.5 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal IMPDH PF00478.25 EDK39903.1 - 7.1e-135 449.5 5.3 8.1e-135 449.3 5.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EDK39903.1 - 1.4e-12 47.9 0.1 5.7e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EDK39903.1 - 1.7e-08 34.2 4.6 0.00024 20.6 4.2 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EDK39903.1 - 1.9e-07 30.5 3.3 5.2e-07 29.0 2.9 1.9 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EDK39903.1 - 2.1e-05 24.1 1.0 0.00015 21.3 1.0 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EDK39903.1 - 0.00014 21.3 2.0 0.00092 18.6 0.5 2.2 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG Aldolase PF01081.19 EDK39903.1 - 0.0044 16.5 0.1 0.018 14.4 0.1 2.0 1 0 0 1 1 1 1 KDPG and KHG aldolase PK PF00224.21 EDK39903.1 - 0.035 13.0 0.2 0.17 10.7 0.0 2.2 2 0 0 2 2 2 0 Pyruvate kinase, barrel domain SNRNP27 PF08648.12 EDK39903.1 - 0.085 12.9 0.2 0.21 11.7 0.2 1.7 1 0 0 1 1 1 0 U4/U6.U5 small nuclear ribonucleoproteins YpsA PF06908.11 EDK39903.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 YspA SLOG family MFS_1 PF07690.16 EDK39904.2 - 7.5e-15 54.7 38.0 9e-10 38.0 27.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK39904.2 - 1.1e-05 24.1 17.7 1.4e-05 23.7 17.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Insulin_TMD PF17870.1 EDK39904.2 - 4.1 7.5 8.7 0.21 11.7 0.3 3.3 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment Glyco_hydro_20 PF00728.22 EDK39905.2 - 1.8e-99 333.5 0.5 2.3e-99 333.2 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EDK39905.2 - 8.9e-13 49.1 0.0 3.3e-11 44.0 0.0 2.5 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EDK39905.2 - 0.0072 17.1 0.0 0.012 16.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 3Beta_HSD PF01073.19 EDK39906.2 - 1.7e-26 92.9 0.2 2.1e-26 92.6 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDK39906.2 - 1.5e-25 90.0 0.1 2.1e-25 89.6 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EDK39906.2 - 1.2e-15 57.4 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK39906.2 - 2.1e-13 50.4 0.2 3.1e-13 49.8 0.2 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDK39906.2 - 3.1e-13 50.0 1.8 4.3e-13 49.6 1.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EDK39906.2 - 9.8e-10 38.4 0.9 3.1e-08 33.5 0.3 2.2 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EDK39906.2 - 1.7e-09 37.2 1.1 1.8e-09 37.1 0.2 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDK39906.2 - 1.9e-05 24.2 1.9 0.00011 21.8 1.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK39906.2 - 0.0018 18.2 1.9 0.015 15.3 1.9 2.0 1 1 0 1 1 1 1 KR domain FAM209 PF15206.6 EDK39906.2 - 0.064 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 FAM209 family p450 PF00067.22 EDK39907.2 - 5.6e-64 216.6 1.0 7e-64 216.3 1.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 EDK39908.1 - 5.8e-115 384.7 23.4 6.8e-115 384.5 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK39908.1 - 8.2e-20 71.0 36.4 2.9e-14 52.8 12.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HlyIII PF03006.20 EDK39909.2 - 4.4e-56 190.1 6.2 6.2e-56 189.6 6.2 1.2 1 0 0 1 1 1 1 Haemolysin-III related LicD PF04991.13 EDK39910.2 - 1.2e-21 78.0 15.5 5.5e-21 75.7 0.5 4.2 3 1 1 4 4 4 2 LicD family Aldo_ket_red PF00248.21 EDK39911.2 - 1.1e-45 156.1 0.7 3e-43 148.1 0.7 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Peripla_BP_4 PF13407.6 EDK39911.2 - 0.063 12.8 0.0 0.3 10.6 0.0 2.0 2 1 1 3 3 3 0 Periplasmic binding protein domain MinC_N PF05209.13 EDK39911.2 - 0.14 12.1 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain Ada_Zn_binding PF02805.16 EDK39912.2 - 8.4e-27 93.0 2.2 1.3e-26 92.4 2.2 1.3 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 EDK39912.2 - 1.5e-05 24.9 0.1 2.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 EDK39912.2 - 0.0013 19.0 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3818 PF12825.7 EDK39913.2 - 1.7e-97 326.5 9.1 1.7e-97 326.5 9.1 1.7 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDK39913.2 - 2e-33 115.2 0.4 5.5e-33 113.7 0.4 1.8 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EDK39913.2 - 5.6e-08 32.8 1.8 1.4e-07 31.5 0.7 2.4 2 0 0 2 2 2 1 PX domain CAF1 PF04857.20 EDK39915.2 - 9.6e-05 21.7 4.9 0.0019 17.4 0.0 2.9 2 1 0 3 3 3 2 CAF1 family ribonuclease Mito_carr PF00153.27 EDK39915.2 - 0.61 10.0 5.6 6.5 6.7 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial carrier protein PA28_alpha PF02251.18 EDK39917.1 - 0.055 13.5 2.2 2.5 8.2 0.1 3.9 1 1 3 4 4 4 0 Proteasome activator pa28 alpha subunit PRANC PF09372.10 EDK39917.1 - 0.058 13.7 0.1 15 6.0 0.0 2.3 1 1 0 2 2 2 0 PRANC domain Exo5 PF09810.9 EDK39917.1 - 0.087 12.3 4.9 0.39 10.2 0.9 2.0 1 1 1 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease RGS PF00615.19 EDK39917.1 - 0.26 11.6 5.4 3 8.2 0.1 3.9 2 1 1 3 3 3 0 Regulator of G protein signaling domain DUF3350 PF11830.8 EDK39917.1 - 0.61 10.4 2.7 7 7.0 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3350) RabGAP-TBC PF00566.18 EDK39917.1 - 4.7 6.8 11.1 2.2 7.9 4.2 2.1 1 1 1 2 2 2 0 Rab-GTPase-TBC domain CDC50 PF03381.15 EDK39918.1 - 2e-94 316.3 2.3 2.4e-94 316.0 2.3 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family TcdB_toxin_midC PF12255.8 EDK39918.1 - 0.052 13.6 0.2 0.096 12.8 0.2 1.4 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/C-terminal region NTF2 PF02136.20 EDK39919.2 - 4.4e-14 53.1 0.0 9.8e-14 52.0 0.0 1.6 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EDK39919.2 - 0.024 14.4 0.0 0.067 13.0 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hid1 PF12722.7 EDK39919.2 - 9.3 4.2 11.9 14 3.6 11.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UQ_con PF00179.26 EDK39920.2 - 1.1e-44 151.5 0.0 1.3e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EDK39920.2 - 2.9e-18 65.4 0.1 4.6e-18 64.8 0.1 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EDK39920.2 - 0.0032 17.2 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDK39920.2 - 0.033 14.5 0.1 0.063 13.6 0.1 1.5 1 0 0 1 1 1 0 RWD domain UBA PF00627.31 EDK39920.2 - 0.06 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain Not1 PF04054.15 EDK39921.2 - 9.6e-133 442.6 0.0 2.5e-132 441.2 0.0 1.7 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EDK39921.2 - 4.7e-83 278.0 0.0 2e-82 276.0 0.0 2.1 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_HEAT_N PF16419.5 EDK39921.2 - 6.8e-51 173.1 4.5 9.3e-51 172.7 0.8 2.9 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_TTP_bind PF16417.5 EDK39921.2 - 4.8e-49 166.1 0.3 1.4e-48 164.6 0.3 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EDK39921.2 - 3.2e-31 108.2 1.5 8.3e-31 106.9 1.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EDK39921.2 - 1.4e-20 73.9 0.4 4.8e-20 72.2 0.3 2.1 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF2420 PF10336.9 EDK39921.2 - 0.037 14.1 0.2 0.19 11.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) RabGAP-TBC PF00566.18 EDK39922.2 - 4.6e-38 131.0 5.1 1e-37 129.9 5.1 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Fer2_3 PF13085.6 EDK39922.2 - 0.12 12.4 0.1 0.39 10.7 0.1 1.9 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain NFACT-R_1 PF05670.13 EDK39923.2 - 4.8e-36 123.7 0.3 4.8e-36 123.7 0.3 1.9 2 0 0 2 2 2 1 NFACT protein RNA binding domain DUF4284 PF14112.6 EDK39923.2 - 0.026 15.5 1.6 0.036 15.0 0.2 1.9 2 0 0 2 2 2 0 Immunity protein 22 COX6B PF02297.17 EDK39924.1 - 1.4e-17 63.7 4.3 1.6e-17 63.5 4.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EDK39924.1 - 0.015 15.3 2.2 0.023 14.7 2.2 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDK39924.1 - 0.043 13.9 0.7 0.071 13.3 0.7 1.4 1 0 0 1 1 1 0 CHCH domain Ndc1_Nup PF09531.10 EDK39925.2 - 4.6 5.8 5.7 4.7 5.8 5.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Aminotran_5 PF00266.19 EDK39926.2 - 9.9e-26 90.6 0.0 1.2e-25 90.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EDK39926.2 - 0.015 14.5 0.2 0.027 13.7 0.2 1.3 1 1 0 1 1 1 0 Aminotransferase class I and II MS_channel PF00924.18 EDK39926.2 - 0.052 13.1 0.4 0.11 12.1 0.4 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel KR PF08659.10 EDK39926.2 - 0.091 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 KR domain EAP30 PF04157.16 EDK39926.2 - 0.11 11.8 0.1 0.32 10.2 0.0 1.7 2 0 0 2 2 2 0 EAP30/Vps36 family DnaJ PF00226.31 EDK39927.2 - 4.4e-20 71.6 1.4 4.4e-20 71.6 1.4 2.4 2 0 0 2 2 2 1 DnaJ domain CTNNBL PF08216.11 EDK39927.2 - 0.22 11.7 5.1 0.085 13.0 2.1 1.9 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear DUF3774 PF12609.8 EDK39927.2 - 0.7 10.9 3.9 5 8.2 2.8 2.7 2 1 0 2 2 2 0 Wound-induced protein BING4CT PF08149.11 EDK39927.2 - 1.3 8.9 4.9 1.4 8.7 0.3 2.8 3 0 0 3 3 3 0 BING4CT (NUC141) domain DNA_topoisoIV PF00521.20 EDK39928.2 - 2.8e-126 421.9 0.3 5.9e-126 420.8 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EDK39928.2 - 4.7e-48 162.7 0.1 1.5e-47 161.1 0.1 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EDK39928.2 - 9.3e-29 100.1 2.4 2.5e-28 98.7 2.4 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EDK39928.2 - 3e-14 53.5 0.4 8.7e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EDK39928.2 - 2.8e-07 30.7 0.0 1.1e-06 28.8 0.0 2.1 1 0 0 1 1 1 1 Toprim domain DUF2576 PF10845.8 EDK39928.2 - 0.12 12.0 0.3 0.4 10.3 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) STPPase_N PF16891.5 EDK39928.2 - 0.74 10.3 2.3 1.3 9.6 0.8 2.3 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain GTP_cyclohydro2 PF00925.20 EDK39929.1 - 2.6e-61 206.0 0.0 3.6e-61 205.5 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Fungal_trans PF04082.18 EDK39930.2 - 1.6e-33 115.9 1.8 1.6e-33 115.9 1.8 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK39930.2 - 1.6e-09 37.7 10.8 1.6e-09 37.7 10.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pigment_DH PF06324.11 EDK39930.2 - 0.034 14.2 0.0 0.12 12.4 0.0 2.0 1 0 0 1 1 1 0 Pigment-dispersing hormone (PDH) PBP1_TM PF14812.6 EDK39930.2 - 0.17 12.3 1.2 22 5.5 0.0 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNase_PH PF01138.21 EDK39931.1 - 1.2e-25 90.5 0.1 1.9e-25 89.9 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.13 EDK39932.2 - 3.8e-59 197.7 7.5 1.4e-35 121.9 0.5 2.9 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 EDK39932.2 - 0.0049 16.7 0.2 0.012 15.5 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 EDK39932.2 - 0.0072 16.9 0.4 0.026 15.1 0.3 2.0 2 0 0 2 2 2 1 SKICH domain GPI-anchored PF10342.9 EDK39932.2 - 0.055 14.2 0.3 0.17 12.6 0.2 2.0 1 1 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DEAD PF00270.29 EDK39933.2 - 3.8e-49 166.8 0.0 2.1e-48 164.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39933.2 - 4e-14 52.9 0.0 1.8e-13 50.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39933.2 - 9.9e-05 22.4 0.0 0.00019 21.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDK39933.2 - 0.00066 20.0 0.0 0.32 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EDK39933.2 - 0.013 15.2 0.0 0.51 10.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF5335 PF17269.2 EDK39933.2 - 0.015 15.1 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5335) RNA_pol_L_2 PF13656.6 EDK39934.2 - 6.2e-33 112.4 0.1 7.8e-33 112.1 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDK39934.2 - 5.5e-15 54.6 0.0 7.3e-15 54.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SID PF11778.8 EDK39935.2 - 5.7e-06 26.5 1.9 1.1e-05 25.6 0.8 2.0 1 1 1 2 2 2 1 Septation initiation CENP-F_N PF10481.9 EDK39935.2 - 0.045 13.4 0.4 0.045 13.4 0.4 2.2 2 0 0 2 2 2 0 Cenp-F N-terminal domain DivIC PF04977.15 EDK39935.2 - 0.2 11.4 3.8 0.65 9.8 3.8 1.8 1 0 0 1 1 1 0 Septum formation initiator CENP-H PF05837.12 EDK39935.2 - 0.81 10.1 5.4 0.32 11.4 1.8 2.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) PRKG1_interact PF15898.5 EDK39935.2 - 1.3 9.9 8.4 5.3 8.0 1.2 2.7 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 EDK39935.2 - 2.9 8.4 10.3 0.6 10.6 4.2 2.4 2 0 0 2 2 2 0 Cell division protein ZapB zf-C2H2 PF00096.26 EDK39936.2 - 4.2e-22 77.3 30.3 7.8e-06 26.1 0.9 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK39936.2 - 9.6e-19 66.9 31.5 1.5e-07 31.5 0.5 4.8 5 0 0 5 5 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK39936.2 - 6.8e-13 48.3 25.9 0.0057 17.4 1.8 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK39936.2 - 6.5e-09 35.6 25.9 0.0003 20.7 2.2 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 EDK39936.2 - 1e-06 28.9 12.1 0.0077 16.6 0.1 4.5 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK39936.2 - 3.1e-05 24.1 7.8 0.59 10.5 0.8 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EDK39936.2 - 0.0051 17.1 10.1 0.095 13.0 6.4 2.5 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 EDK39936.2 - 0.13 12.1 2.3 0.79 9.6 0.3 3.1 1 1 2 3 3 3 0 GAGA factor zf-BED PF02892.15 EDK39936.2 - 0.22 11.6 20.6 0.36 10.9 1.6 4.0 3 1 1 4 4 4 0 BED zinc finger zf-Dof PF02701.15 EDK39936.2 - 0.48 10.6 9.6 0.63 10.2 3.9 3.4 1 1 2 3 3 3 0 Dof domain, zinc finger DUF2256 PF10013.9 EDK39936.2 - 1.2 9.3 6.7 6.7 6.9 0.4 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) DZR PF12773.7 EDK39936.2 - 3.1 7.9 5.5 13 5.9 5.5 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_2 PF12756.7 EDK39936.2 - 7.2 7.0 14.2 6.1 7.2 1.4 3.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) RSN1_7TM PF02714.15 EDK39937.2 - 7.3e-92 307.5 26.2 1.4e-91 306.6 26.2 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDK39937.2 - 2.1e-41 141.3 1.4 2.1e-41 141.3 1.4 2.6 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDK39937.2 - 4e-30 105.3 0.7 4e-30 105.3 0.7 1.6 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDK39937.2 - 4.7e-28 97.2 0.0 1.3e-27 95.8 0.0 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF349 PF03993.12 EDK39937.2 - 8 6.8 6.0 29 5.0 0.2 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Pyrophosphatase PF00719.19 EDK39938.2 - 7.3e-54 181.9 0.0 9.4e-54 181.5 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.9 EDK39939.2 - 9.9e-291 966.9 31.5 9.9e-291 966.9 31.5 1.8 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 EDK39939.2 - 5.4e-26 91.3 4.1 1e-25 90.4 4.1 1.5 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain GHMP_kinases_N PF00288.26 EDK39940.2 - 1e-15 57.7 0.4 3e-15 56.2 0.4 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDK39940.2 - 1.1e-08 35.3 0.0 5.7e-08 33.0 0.0 2.3 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EDK39940.2 - 2.6e-05 23.7 0.6 0.00024 20.6 0.1 2.3 2 0 0 2 2 2 1 Galactokinase galactose-binding signature Mtc PF03820.17 EDK39941.2 - 9.3e-122 405.9 0.3 1e-121 405.8 0.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier ACPS PF01648.20 EDK39942.1 - 2.7e-14 53.3 0.0 3.1e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily GMP_synt_C PF00958.22 EDK39943.2 - 1.1e-43 147.2 0.2 2.7e-43 145.9 0.2 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EDK39943.2 - 3.6e-40 137.8 0.0 6.2e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EDK39943.2 - 2.3e-09 36.7 0.0 8.9e-06 25.0 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EDK39943.2 - 1.6e-07 31.3 0.3 1.1e-06 28.5 0.1 2.4 2 1 0 2 2 2 1 Peptidase C26 QueC PF06508.13 EDK39943.2 - 0.00087 18.8 0.0 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 EDK39943.2 - 0.017 14.7 0.0 0.038 13.6 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EDK39943.2 - 0.02 13.7 0.0 0.038 12.8 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase HOASN PF14515.6 EDK39943.2 - 0.06 13.7 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices ATP_bind_3 PF01171.20 EDK39943.2 - 0.084 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 PP-loop family sCache_like PF16736.5 EDK39943.2 - 0.18 11.9 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Single Cache-like WD40 PF00400.32 EDK39945.2 - 7.6e-24 83.5 14.1 4.6e-06 27.3 0.1 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat NLE PF08154.12 EDK39945.2 - 1.4e-23 83.2 0.3 2.3e-23 82.5 0.3 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 EDK39945.2 - 6.4e-08 31.7 1.7 0.00033 19.4 0.3 2.3 1 1 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDK39945.2 - 0.0088 16.3 1.0 9.4 6.6 0.0 3.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain N2227 PF07942.12 EDK39946.2 - 9e-52 175.9 0.6 1.2e-51 175.5 0.6 1.1 1 0 0 1 1 1 1 N2227-like protein Herpes_U34 PF04541.13 EDK39946.2 - 0.02 14.2 0.8 0.035 13.4 0.2 1.7 2 0 0 2 2 2 0 Herpesvirus virion protein U34 C8 PF08742.11 EDK39946.2 - 0.27 11.7 1.0 0.99 9.9 0.1 2.2 2 0 0 2 2 2 0 C8 domain PPTA PF01239.22 EDK39947.2 - 1.8e-35 119.6 17.0 4.6e-09 35.7 2.0 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PSCyt2 PF07583.11 EDK39947.2 - 0.011 15.6 0.8 0.2 11.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1549) Hist_deacetyl PF00850.19 EDK39948.2 - 1.6e-52 178.9 0.5 6.5e-51 173.6 0.1 2.5 2 1 0 2 2 2 1 Histone deacetylase domain RhoGAP PF00620.27 EDK39949.2 - 2.5e-17 63.1 0.0 5.1e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EDK39949.2 - 3.7e-11 43.5 0.1 1e-10 42.1 0.1 1.8 1 0 0 1 1 1 1 PH domain PX PF00787.24 EDK39949.2 - 1.8e-06 27.9 0.1 5.2e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 PX domain PH_6 PF15406.6 EDK39949.2 - 0.029 14.7 0.0 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4939 PF16297.5 EDK39949.2 - 0.14 12.1 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) Fungal_TACC PF12709.7 EDK39950.2 - 8.4e-25 87.0 6.0 8.4e-25 87.0 6.0 3.4 3 0 0 3 3 3 1 Fungal Transforming acidic coiled-coil (TACC) proteins TPR_MLP1_2 PF07926.12 EDK39950.2 - 0.0021 18.1 34.6 0.0079 16.3 3.9 3.1 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 EDK39950.2 - 0.015 15.1 8.5 0.015 15.1 8.5 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) RecG_N PF17190.4 EDK39950.2 - 0.02 15.6 7.2 0.02 15.6 7.2 3.0 1 1 1 3 3 3 0 RecG N-terminal helical domain ZapB PF06005.12 EDK39950.2 - 0.023 15.1 36.2 0.049 14.1 15.2 3.3 3 0 0 3 3 3 0 Cell division protein ZapB DUF883 PF05957.13 EDK39950.2 - 0.025 15.2 7.6 0.025 15.2 7.6 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) Spectrin PF00435.21 EDK39950.2 - 0.028 14.9 27.3 0.06 13.8 15.5 2.8 1 1 2 3 3 3 0 Spectrin repeat Sbi-IV PF11621.8 EDK39950.2 - 0.04 14.3 0.3 0.04 14.3 0.3 3.2 3 2 0 3 3 3 0 C3 binding domain 4 of IgG-bind protein SBI TSC22 PF01166.18 EDK39950.2 - 0.052 13.9 17.7 0.36 11.2 5.4 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family Golgin_A5 PF09787.9 EDK39950.2 - 0.092 12.2 35.2 0.1 12.0 5.0 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF5076 PF16826.5 EDK39950.2 - 0.11 12.4 7.9 4.2 7.4 0.1 3.5 2 2 1 4 4 4 0 Domain of unknown function (DUF5076) ADIP PF11559.8 EDK39950.2 - 0.12 12.5 38.1 1 9.4 2.5 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF3437 PF11919.8 EDK39950.2 - 0.12 12.3 4.2 3.9 7.4 0.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF3437) YabA PF06156.13 EDK39950.2 - 0.21 12.2 30.2 0.23 12.1 11.9 3.1 1 1 1 3 3 3 0 Initiation control protein YabA Apolipoprotein PF01442.18 EDK39950.2 - 0.31 10.9 27.4 0.12 12.3 19.9 2.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4407 PF14362.6 EDK39950.2 - 0.33 10.3 24.5 0.25 10.7 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3107 PF11305.8 EDK39950.2 - 0.39 11.0 6.9 0.5 10.7 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3107) Mod_r PF07200.13 EDK39950.2 - 0.59 10.2 32.5 3.7 7.6 13.8 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YvrJ PF12841.7 EDK39950.2 - 0.71 9.5 6.3 2.7 7.6 1.1 3.4 4 0 0 4 4 3 0 YvrJ protein family KASH_CCD PF14662.6 EDK39950.2 - 1.3 8.8 34.7 3.4 7.4 19.0 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Jnk-SapK_ap_N PF09744.9 EDK39950.2 - 1.5 9.1 33.5 1.3 9.3 21.8 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1690 PF07956.11 EDK39950.2 - 1.8 9.0 28.9 3.7 8.0 20.3 2.5 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) AKNA PF12443.8 EDK39950.2 - 1.8 9.3 21.3 1.4 9.6 0.5 3.1 2 1 1 3 3 3 0 AT-hook-containing transcription factor bZIP_1 PF00170.21 EDK39950.2 - 2 8.6 25.5 6 7.0 2.6 3.8 3 1 0 3 3 3 0 bZIP transcription factor FUSC PF04632.12 EDK39950.2 - 2 6.9 5.4 2.5 6.5 5.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2937 PF11157.8 EDK39950.2 - 2.3 7.9 6.4 1.6 8.5 3.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) Sacchrp_dh_NADP PF03435.18 EDK39950.2 - 2.3 8.5 5.6 9.5 6.5 0.1 2.6 2 2 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF999 PF06198.11 EDK39950.2 - 2.5 8.1 8.4 1.2 9.1 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF999) LRRFIP PF09738.9 EDK39950.2 - 3.3 7.1 32.2 0.1 12.0 3.5 2.5 1 1 1 2 2 2 0 LRRFIP family ACP_PD PF04336.12 EDK39950.2 - 4.2 7.8 8.8 3.5 8.1 4.6 2.6 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase Cnn_1N PF07989.11 EDK39950.2 - 4.4 7.5 31.5 0.73 10.0 1.7 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 YlqD PF11068.8 EDK39950.2 - 4.8 7.6 32.5 1.4 9.3 15.1 2.6 1 1 1 2 2 2 0 YlqD protein KfrA_N PF11740.8 EDK39950.2 - 5 7.8 19.3 2.1 9.0 3.0 3.2 1 1 1 2 2 1 0 Plasmid replication region DNA-binding N-term Cauli_DNA-bind PF03310.13 EDK39950.2 - 5.4 7.1 13.6 1.6 8.8 8.9 2.1 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein DUF1664 PF07889.12 EDK39950.2 - 6.7 6.8 22.1 2.1 8.4 8.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlxA PF14282.6 EDK39950.2 - 7 6.7 35.6 5.3 7.1 18.4 3.4 1 1 1 3 3 3 0 FlxA-like protein TipAS PF07739.13 EDK39950.2 - 8.2 7.0 16.0 0.45 11.1 8.0 2.4 1 1 2 3 3 3 0 TipAS antibiotic-recognition domain FAM184 PF15665.5 EDK39951.2 - 0.0074 16.1 13.1 0.0074 16.1 13.1 2.5 2 0 0 2 2 2 1 Family with sequence similarity 184, A and B APG6_N PF17675.1 EDK39951.2 - 7.3 7.1 69.5 4.2 7.9 25.0 3.4 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF3552 PF12072.8 EDK39951.2 - 9.5 5.6 60.3 0.25 10.7 28.1 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Peptidase_M20 PF01546.28 EDK39953.2 - 7.3e-32 110.7 0.0 3.1e-31 108.7 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK39953.2 - 6.1e-12 45.4 0.0 1.1e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDK39953.2 - 7.7e-05 22.5 0.1 0.00032 20.4 0.1 1.9 1 1 0 1 1 1 1 Peptidase family M28 PyrBI_leader PF08052.11 EDK39953.2 - 0.1 12.6 0.1 0.33 11.0 0.1 1.9 1 0 0 1 1 1 0 PyrBI operon leader peptide RNA_pol_N PF01194.17 EDK39954.1 - 6.3e-30 103.3 1.2 7.3e-30 103.1 1.2 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit WD40 PF00400.32 EDK39955.2 - 1.5e-05 25.6 14.3 0.0067 17.3 0.0 7.5 6 2 2 8 8 8 2 WD domain, G-beta repeat Dynamin_N PF00350.23 EDK39956.2 - 1.2e-42 145.9 0.0 2.8e-42 144.6 0.0 1.7 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EDK39956.2 - 7.7e-06 26.0 0.0 4.7e-05 23.5 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 EDK39956.2 - 0.012 14.9 3.4 0.073 12.3 1.9 2.7 2 1 0 2 2 2 0 Dynamin central region AAA_21 PF13304.6 EDK39956.2 - 0.056 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF1140 PF06600.11 EDK39956.2 - 0.071 13.5 0.5 1.9 9.0 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) AAA_15 PF13175.6 EDK39956.2 - 0.16 11.6 0.0 0.16 11.6 0.0 2.5 3 1 0 3 3 3 0 AAA ATPase domain Uds1 PF15456.6 EDK39956.2 - 0.25 11.5 2.4 1.4 9.1 0.2 3.0 2 0 0 2 2 2 0 Up-regulated During Septation NOA36 PF06524.12 EDK39956.2 - 1.1 8.5 9.7 1.9 7.7 9.7 1.3 1 0 0 1 1 1 0 NOA36 protein Transp_cyt_pur PF02133.15 EDK39957.2 - 2e-53 181.8 36.4 2.4e-53 181.5 36.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DNA_pol_phi PF04931.13 EDK39958.2 - 0.89 7.6 12.1 1 7.4 12.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 EDK39958.2 - 1.3 7.5 12.8 1.8 7.1 12.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 EDK39958.2 - 3.7 6.8 10.8 3.9 6.7 10.8 1.1 1 0 0 1 1 1 0 BUD22 Na_trans_assoc PF06512.13 EDK39958.2 - 3.7 7.8 9.6 5.7 7.2 9.6 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Ribosomal_60s PF00428.19 EDK39959.1 - 7.6e-23 80.9 14.6 9.5e-23 80.6 14.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MAM33 PF02330.16 EDK39960.2 - 3.3e-50 171.0 5.9 3.9e-50 170.7 5.9 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein Salt_tol_Pase PF09506.10 EDK39960.2 - 0.048 12.4 0.0 0.098 11.4 0.0 1.4 1 1 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) Phage_int_SAM_5 PF13102.6 EDK39960.2 - 0.11 12.9 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Phage integrase SAM-like domain Cyclin_N PF00134.23 EDK39961.2 - 7.6e-45 151.8 0.3 1.3e-44 151.0 0.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDK39961.2 - 2.2e-36 124.5 0.0 4.5e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF3844 PF12955.7 EDK39963.2 - 2.5e-28 98.3 5.8 4.6e-28 97.4 5.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Lipase_GDSL_2 PF13472.6 EDK39963.2 - 0.043 14.2 0.0 0.15 12.4 0.0 1.8 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family RBD PF02196.15 EDK39963.2 - 0.13 12.4 0.1 0.9 9.7 0.1 2.2 2 0 0 2 2 2 0 Raf-like Ras-binding domain Evr1_Alr PF04777.13 EDK39964.2 - 1.3e-26 93.0 0.1 2.2e-26 92.2 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC1 PF18769.1 EDK39964.2 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 APOBEC1 V-SNARE_C PF12352.8 EDK39965.2 - 2.1e-12 47.1 0.2 2.1e-12 47.1 0.2 2.2 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus HYLS1_C PF15311.6 EDK39965.2 - 0.018 15.7 1.1 0.91 10.3 0.2 2.4 1 1 1 2 2 2 0 Hydrolethalus syndrome protein 1 C-terminus Syntaxin-6_N PF09177.11 EDK39965.2 - 0.15 12.6 6.7 0.22 12.1 4.3 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Peptidase_M3_N PF08439.10 EDK39965.2 - 0.33 11.2 2.2 2.4 8.5 0.0 2.9 3 1 1 4 4 4 0 Oligopeptidase F Sec20 PF03908.13 EDK39965.2 - 1.1 9.3 5.7 2.5 8.1 0.1 2.7 2 1 1 3 3 3 0 Sec20 DUF4570 PF15134.6 EDK39965.2 - 2 8.5 11.9 1.8 8.6 5.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4570) DUF1691 PF07950.11 EDK39966.2 - 3.9e-16 59.7 6.0 2.7e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Stevor PF17410.2 EDK39966.2 - 0.25 10.9 0.0 0.41 10.2 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Sdh_cyt PF01127.22 EDK39966.2 - 1 9.4 9.1 15 5.6 6.6 2.5 2 1 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit NifU_N PF01592.16 EDK39967.1 - 8.3e-58 194.1 0.1 1.1e-57 193.7 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EDK39967.1 - 0.1 12.8 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 TSCPD domain LRR_4 PF12799.7 EDK39968.2 - 6.8 7.3 17.4 15 6.2 0.5 5.3 4 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Ribosomal_L5e PF17144.4 EDK39969.1 - 2.1e-79 265.2 0.0 4.1e-79 264.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EDK39969.1 - 5.7e-32 110.5 8.5 5.7e-32 110.5 8.5 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1160 PF06648.11 EDK39969.1 - 0.061 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) Ribosomal_L18p PF00861.22 EDK39969.1 - 0.07 13.5 0.4 0.16 12.4 0.0 1.7 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast NAC PF01849.18 EDK39969.1 - 0.091 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 NAC domain GCR1_C PF12550.8 EDK39969.1 - 0.16 12.3 5.0 6.8 7.1 0.8 2.4 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Thr_synth_N PF14821.6 EDK39969.1 - 0.17 12.1 0.9 5.6 7.2 0.0 2.9 3 1 0 3 3 3 0 Threonine synthase N terminus NAD_binding_5 PF07994.12 EDK39969.1 - 0.38 10.1 2.3 9.1 5.5 2.3 2.1 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase SPT6_acidic PF14632.6 EDK39969.1 - 2 9.1 7.9 5.4 7.7 7.9 1.7 1 1 0 1 1 1 0 Acidic N-terminal SPT6 NAPRTase PF04095.16 EDK39970.2 - 1.6e-66 224.3 0.2 2.2e-66 223.9 0.2 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EDK39970.2 - 4.2e-37 127.3 0.7 8.4e-37 126.3 0.7 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain AbrB_C PF18277.1 EDK39970.2 - 0.0069 16.0 0.6 0.15 11.7 0.0 2.7 3 0 0 3 3 3 1 AbrB C-terminal domain IBN_N PF03810.19 EDK39971.2 - 2.4e-15 56.2 0.6 3e-14 52.7 0.1 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EDK39971.2 - 0.041 13.9 3.4 0.13 12.3 0.3 3.2 2 0 0 2 2 2 0 Exportin 1-like protein CtaG_Cox11 PF04442.14 EDK39972.2 - 7.3e-59 198.1 0.2 1e-58 197.6 0.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Cupredoxin_1 PF13473.6 EDK39972.2 - 0.048 13.8 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 Cupredoxin-like domain CPDase PF07823.11 EDK39973.2 - 2.9e-51 174.0 0.1 2.9e-50 170.7 0.1 1.9 1 1 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 EDK39973.2 - 3.1e-05 23.9 0.7 0.06 13.3 1.0 2.8 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EDK39973.2 - 0.012 15.8 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 LigT like Phosphoesterase PurS PF02700.14 EDK39973.2 - 0.027 14.7 0.2 1 9.6 0.0 2.2 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase Glucosamine_iso PF01182.20 EDK39974.1 - 2e-64 217.6 0.0 2.2e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase NMD3 PF04981.13 EDK39975.2 - 6e-82 274.8 4.8 1.1e-81 273.9 4.8 1.4 1 0 0 1 1 1 1 NMD3 family Ureide_permease PF07168.11 EDK39975.2 - 0.032 13.0 0.1 0.053 12.3 0.1 1.2 1 0 0 1 1 1 0 Ureide permease VPS11_C PF12451.8 EDK39975.2 - 0.19 12.0 3.0 0.47 10.7 3.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal HypA PF01155.19 EDK39975.2 - 1.3 9.1 7.8 4.4 7.4 0.1 2.7 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Bromodomain PF00439.25 EDK39976.2 - 2.6e-27 94.7 0.6 5.6e-27 93.6 0.6 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EDK39976.2 - 2.1e-08 34.4 0.0 4.8e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK39976.2 - 5.1e-06 26.4 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK39976.2 - 0.0013 19.1 0.1 0.0025 18.2 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain UBA_e1_thiolCys PF10585.9 EDK39976.2 - 0.02 14.8 1.9 0.052 13.5 1.9 1.6 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site DUF1492 PF07374.11 EDK39976.2 - 0.045 13.9 0.3 0.097 12.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) CobT PF06213.12 EDK39976.2 - 0.32 10.3 8.5 0.52 9.7 8.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RPA43_OB PF17875.1 EDK39976.2 - 0.34 11.5 6.0 0.84 10.3 6.0 1.7 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I GNAT_acetyltr_2 PF13718.6 EDK39976.2 - 0.62 9.4 3.0 7.3 5.9 0.0 2.5 2 0 0 2 2 2 0 GNAT acetyltransferase 2 CDC45 PF02724.14 EDK39976.2 - 1.7 6.8 10.4 2.4 6.3 10.4 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 EDK39976.2 - 2.1 7.6 14.6 3.1 7.1 14.6 1.2 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EDK39976.2 - 3.6 6.8 14.9 5.7 6.2 14.9 1.2 1 0 0 1 1 1 0 NOA36 protein TFIIE-A_C PF11521.8 EDK39976.2 - 4.7 7.6 16.8 0.36 11.1 11.3 2.0 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Presenilin PF01080.17 EDK39976.2 - 7.9 5.1 5.7 12 4.6 5.7 1.2 1 0 0 1 1 1 0 Presenilin SDA1 PF05285.12 EDK39976.2 - 9.7 5.5 18.9 16 4.8 18.9 1.2 1 0 0 1 1 1 0 SDA1 DUF1290 PF06947.12 EDK39977.2 - 0.044 13.9 1.8 0.051 13.7 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1290) CCDC24 PF15669.5 EDK39978.2 - 0.046 13.6 0.1 0.064 13.1 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Phage_Coat_Gp8 PF05371.12 EDK39978.2 - 0.47 10.3 5.1 8.4 6.3 0.6 2.5 2 1 0 2 2 2 0 Phage major coat protein, Gp8 ATG7_N PF16420.5 EDK39979.2 - 4.2e-62 210.5 3.5 7.5e-62 209.7 3.5 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EDK39979.2 - 2.9e-44 151.2 0.0 4.7e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 EDK39979.2 - 0.0017 17.7 0.0 0.049 13.0 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDK39979.2 - 0.0099 15.9 0.0 0.05 13.7 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 EDK39979.2 - 0.11 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GCP_N_terminal PF17681.1 EDK39980.2 - 3.5e-47 161.5 3.0 8.6e-47 160.2 0.3 2.6 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDK39980.2 - 4e-24 85.6 9.1 4.9e-15 55.8 0.9 2.9 3 0 0 3 3 3 2 Gamma tubulin complex component C-terminal Proteasome PF00227.26 EDK39981.1 - 9.1e-56 188.4 0.2 1.2e-55 188.0 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDK39981.1 - 2.6e-12 46.2 0.0 5.1e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF1028 PF06267.12 EDK39981.1 - 0.1 12.4 0.5 5.2 6.8 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF1028) ATP-grasp_2 PF08442.10 EDK39982.2 - 6.8e-49 166.2 0.8 1.2e-48 165.4 0.8 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EDK39982.2 - 3.3e-25 88.7 0.0 6e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase AATase PF07247.12 EDK39983.2 - 1.5e-47 162.3 2.9 2.3e-47 161.7 2.9 1.2 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EDK39983.2 - 0.011 14.4 0.2 0.02 13.6 0.2 1.5 1 1 0 1 1 1 0 Condensation domain RRP36 PF06102.12 EDK39984.2 - 1e-47 162.2 27.1 1e-47 162.2 27.1 1.8 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 T3SS_needle_E PF08988.10 EDK39984.2 - 2.5 8.3 7.2 0.34 11.1 2.6 2.0 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Rhodanese PF00581.20 EDK39986.2 - 7e-16 58.7 0.0 1.1e-15 58.1 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Sigma_reg_C PF13791.6 EDK39986.2 - 0.069 13.4 0.0 0.97 9.6 0.0 2.0 2 0 0 2 2 2 0 Sigma factor regulator C-terminal FTHFS PF01268.19 EDK39987.1 - 6.2e-258 856.5 0.1 7.9e-258 856.2 0.1 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDK39987.1 - 5e-65 217.7 0.4 2.7e-64 215.3 0.2 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDK39987.1 - 4.7e-38 130.0 0.3 1e-37 128.9 0.3 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GTP_EFTU PF00009.27 EDK39987.1 - 0.035 13.6 0.1 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain CbiA PF01656.23 EDK39987.1 - 0.092 12.8 0.0 0.72 9.9 0.0 2.3 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AdoHcyase_NAD PF00670.21 EDK39987.1 - 0.13 12.3 0.8 1.6 8.8 0.2 2.7 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acyl_transf_1 PF00698.21 EDK39988.2 - 1.1e-17 64.5 0.0 1.3e-17 64.3 0.0 1.0 1 0 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 EDK39988.2 - 0.0014 18.4 0.2 0.022 14.5 0.1 2.4 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis baeRF_family2 PF18844.1 EDK39988.2 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 HMG_box PF00505.19 EDK39989.1 - 4.6e-08 33.4 8.8 4.6e-08 33.4 8.8 2.8 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDK39989.1 - 0.00025 21.6 6.9 0.00025 21.6 6.9 2.4 2 0 0 2 2 2 1 HMG-box domain DUF1741 PF08427.10 EDK39989.1 - 1.2 8.7 4.4 3 7.4 4.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1741) SDA1 PF05285.12 EDK39990.2 - 1.4e-92 310.8 39.0 6.8e-50 170.4 14.4 3.1 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 EDK39990.2 - 9.5e-24 83.5 0.2 3e-23 81.9 0.2 1.9 1 0 0 1 1 1 1 NUC130/3NT domain EF-hand_14 PF17959.1 EDK39990.2 - 0.015 15.6 0.0 0.059 13.7 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain BSP_II PF05432.11 EDK39990.2 - 3.9 7.1 23.1 0.088 12.5 15.5 1.9 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TFIIB PF00382.19 EDK39991.2 - 2.6e-53 178.0 0.6 4.5e-26 90.7 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EDK39991.2 - 1.9e-28 98.8 0.2 1.9e-28 98.8 0.2 2.6 3 0 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EDK39991.2 - 7.1e-09 35.0 1.7 1.2e-08 34.3 1.7 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 EDK39991.2 - 0.00027 20.7 0.1 0.93 9.2 0.0 2.8 2 0 0 2 2 2 2 Cyclin, N-terminal domain zinc_ribbon_2 PF13240.6 EDK39991.2 - 0.64 9.8 3.2 21 5.0 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DUF202 PF02656.15 EDK39992.2 - 2.4e-15 56.7 4.1 4.1e-15 56.0 0.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Abhydrolase_9_N PF15420.6 EDK39992.2 - 0.019 15.0 0.7 0.02 14.9 0.7 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus PetM PF08041.11 EDK39992.2 - 6.3 6.5 6.8 17 5.1 1.0 2.7 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 HRG PF16954.5 EDK39992.2 - 9.7 6.7 7.7 20 5.7 1.6 3.0 2 1 1 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene DEAD PF00270.29 EDK39993.2 - 1.2e-42 145.6 0.0 2.4e-42 144.7 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK39993.2 - 1.1e-30 106.2 0.0 6.4e-30 103.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK39993.2 - 1.9e-05 24.7 0.0 4.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit GTP1_OBG PF01018.22 EDK39994.1 - 3.4e-36 124.2 3.0 3.9e-26 91.5 2.5 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EDK39994.1 - 3.3e-23 81.9 0.0 1.1e-22 80.3 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK39994.1 - 1.6e-10 40.7 0.0 2.4e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 EDK39994.1 - 3e-05 23.7 0.1 7.3e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Ras family Arf PF00025.21 EDK39994.1 - 6.4e-05 22.5 0.0 0.00022 20.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 EDK39994.1 - 0.00025 21.2 0.3 0.19 11.8 0.0 3.0 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 EDK39994.1 - 0.0013 18.7 0.1 0.021 14.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EDK39994.1 - 0.058 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EDK39994.1 - 0.069 13.7 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter NIBRIN_BRCT_II PF16508.5 EDK39994.1 - 0.081 13.3 0.0 0.33 11.3 0.0 2.0 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein Response_reg PF00072.24 EDK39995.1 - 3.9e-16 59.2 0.0 5.9e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Ribonuc_red_lgC PF02867.15 EDK39996.2 - 2.1e-183 610.7 0.0 2.7e-183 610.3 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDK39996.2 - 1.3e-18 66.8 0.2 2.9e-18 65.6 0.2 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Tfb2 PF03849.14 EDK39997.2 - 2.1e-139 464.5 0.0 3.5e-139 463.7 0.0 1.3 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EDK39997.2 - 1.8e-22 79.5 0.4 4e-22 78.4 0.4 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EDK39997.2 - 0.00018 21.7 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RNA_pol_Rpb2_6 PF00562.28 EDK39998.2 - 8.2e-126 420.2 0.1 8.2e-126 420.2 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDK39998.2 - 2.3e-58 197.1 0.4 3.3e-58 196.5 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDK39998.2 - 2.4e-39 134.9 1.4 5.1e-39 133.9 1.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDK39998.2 - 6e-34 116.3 0.2 1.6e-33 115.0 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDK39998.2 - 9e-25 86.7 0.2 2.9e-24 85.1 0.2 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDK39998.2 - 3e-18 65.8 0.0 6e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDK39998.2 - 2.4e-13 50.4 0.8 7e-13 48.9 0.8 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 zf-RING_2 PF13639.6 EDK39999.2 - 5e-10 39.5 7.4 8.5e-10 38.8 7.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EDK39999.2 - 6.9e-07 28.9 4.2 1.6e-06 27.8 4.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EDK39999.2 - 2e-06 27.7 6.3 3.3e-06 26.9 6.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDK39999.2 - 6e-06 26.4 7.9 2.4e-05 24.5 7.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK39999.2 - 7.8e-06 25.7 6.8 1.3e-05 24.9 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK39999.2 - 9.1e-06 25.6 2.9 1.2e-05 25.3 1.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDK39999.2 - 2.4e-05 24.1 4.2 3.7e-05 23.5 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK39999.2 - 2.4e-05 24.1 6.8 4.2e-05 23.3 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK39999.2 - 0.00088 19.1 5.1 0.0017 18.2 5.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDK39999.2 - 0.0023 17.9 1.6 0.0047 17.0 1.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EDK39999.2 - 0.0026 17.3 2.8 0.0051 16.4 2.8 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EDK39999.2 - 0.03 14.2 1.5 0.4 10.7 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 MOZART1 PF12554.8 EDK39999.2 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated zf-C3H2C3 PF17122.5 EDK39999.2 - 0.38 10.8 3.9 1 9.5 3.9 1.8 1 1 0 1 1 1 0 Zinc-finger RINGv PF12906.7 EDK39999.2 - 1.1 9.5 6.0 2.2 8.5 6.0 1.5 1 0 0 1 1 1 0 RING-variant domain C1_1 PF00130.22 EDK39999.2 - 2.9 7.8 5.8 1 9.3 2.5 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FANCL_C PF11793.8 EDK39999.2 - 7.9 6.7 9.5 17 5.7 7.9 2.4 2 1 0 2 2 1 0 FANCL C-terminal domain Zn_clus PF00172.18 EDK40000.2 - 2.1e-05 24.5 6.7 4.3e-05 23.6 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mu-like_gpT PF10124.9 EDK40000.2 - 0.08 12.3 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 Mu-like prophage major head subunit gpT PAS PF00989.25 EDK40000.2 - 0.12 12.4 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 PAS fold Suf PF05843.14 EDK40000.2 - 4.7 7.1 9.1 0.44 10.5 4.3 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) PAT1 PF09770.9 EDK40000.2 - 5 5.3 10.5 7.3 4.7 10.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Noc2 PF03715.13 EDK40001.2 - 4e-126 420.3 5.8 4e-126 420.3 5.8 1.8 2 0 0 2 2 2 1 Noc2p family DPPIV_N PF00930.21 EDK40002.2 - 4.8e-70 236.1 2.4 7.6e-70 235.4 2.4 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EDK40002.2 - 1.9e-40 138.6 0.4 3.6e-40 137.7 0.4 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EDK40002.2 - 8.1e-07 29.9 0.0 0.0054 17.4 0.0 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase family DUF1741 PF08427.10 EDK40003.2 - 4.3e-08 33.1 0.0 1.3e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Mito_carr PF00153.27 EDK40004.2 - 1.1e-58 195.2 1.0 2.4e-21 75.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RIIa PF02197.17 EDK40004.2 - 0.19 11.4 0.0 9.5 6.0 0.0 2.4 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit WD40 PF00400.32 EDK40005.2 - 1.5e-40 136.4 23.6 7.9e-05 23.3 0.0 10.8 12 0 0 12 12 12 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40005.2 - 4.4e-09 36.5 8.5 0.83 10.0 0.1 8.0 5 3 5 10 10 10 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK40005.2 - 5.6e-05 22.3 0.5 0.00026 20.1 0.1 2.3 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EDK40005.2 - 0.00059 19.8 1.4 17 5.5 0.0 5.5 5 1 1 7 7 7 1 Ciliary BBSome complex subunit 2, middle region Utp8 PF10395.9 EDK40005.2 - 0.014 13.9 0.2 0.095 11.2 0.1 2.0 1 1 1 2 2 2 0 Utp8 family Kelch_6 PF13964.6 EDK40005.2 - 0.056 13.8 3.3 14 6.1 0.1 3.6 4 0 0 4 4 4 0 Kelch motif Hira PF07569.11 EDK40005.2 - 0.063 13.0 0.2 0.26 11.0 0.2 2.1 1 1 0 1 1 1 0 TUP1-like enhancer of split Med20 PF08612.11 EDK40006.2 - 1.9e-51 174.6 0.0 2.2e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex DEAD PF00270.29 EDK40007.2 - 5.8e-47 159.7 0.1 1.2e-46 158.7 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK40007.2 - 1.4e-21 76.9 0.0 7.1e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDK40007.2 - 2e-19 69.6 0.0 5.1e-19 68.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDK40007.2 - 7.3e-07 29.4 0.0 7.3e-07 29.4 0.0 2.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EDK40007.2 - 0.01 16.1 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain PSP PF04046.16 EDK40007.2 - 0.17 11.7 0.0 0.39 10.6 0.0 1.6 1 0 0 1 1 1 0 PSP RNA_pol_Rpc4 PF05132.14 EDK40008.2 - 2.6e-16 60.4 0.0 2.6e-16 60.4 0.0 4.1 2 2 1 3 3 3 2 RNA polymerase III RPC4 Sas10 PF09368.10 EDK40009.2 - 2.6e-29 101.5 11.6 2.6e-29 101.5 11.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EDK40009.2 - 0.026 15.1 0.8 0.14 12.8 0.0 2.7 2 1 0 2 2 2 0 Sas10/Utp3/C1D family Cyclin_C_2 PF16899.5 EDK40010.2 - 8.5e-21 74.3 0.8 1.9e-18 66.8 0.1 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EDK40010.2 - 2.8e-11 43.3 1.6 6e-11 42.2 1.6 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Borrelia_P83 PF05262.11 EDK40010.2 - 0.0017 17.0 0.2 0.0017 17.0 0.2 1.4 2 0 0 2 2 2 1 Borrelia P83/100 protein Astro_capsid_p PF12226.8 EDK40010.2 - 0.021 14.0 0.1 0.021 14.0 0.1 1.7 2 0 0 2 2 2 0 Turkey astrovirus capsid protein CARD_2 PF16739.5 EDK40010.2 - 0.39 10.7 3.3 3.3 7.8 0.1 3.0 3 0 0 3 3 3 0 Caspase recruitment domain Cpn60_TCP1 PF00118.24 EDK40011.2 - 9.6e-149 496.1 15.3 1.1e-148 496.0 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family D123 PF07065.14 EDK40012.2 - 2.8e-97 325.6 0.8 3.2e-97 325.4 0.8 1.0 1 0 0 1 1 1 1 D123 R2K_2 PF18299.1 EDK40012.2 - 0.07 13.0 0.1 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain, R2K clade family 2 DUF2512 PF10710.9 EDK40012.2 - 0.13 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) SGL PF08450.12 EDK40013.2 - 1.8e-67 227.5 0.1 2.3e-67 227.1 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EDK40013.2 - 0.0035 17.4 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 EDK40013.2 - 0.15 12.3 0.0 0.79 10.0 0.0 2.1 2 0 0 2 2 2 0 Arylesterase zf-HIT PF04438.16 EDK40014.1 - 2.4e-12 46.5 8.7 3.2e-12 46.1 8.7 1.2 1 0 0 1 1 1 1 HIT zinc finger Hit1_C PF18268.1 EDK40014.1 - 3.8e-08 33.4 0.0 6.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Hit1 C-terminal YL1_C PF08265.11 EDK40014.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain MerR-DNA-bind PF09278.11 EDK40014.1 - 0.038 14.5 0.1 0.062 13.9 0.1 1.3 1 0 0 1 1 1 0 MerR, DNA binding zf-MYND PF01753.18 EDK40014.1 - 0.055 13.6 6.7 0.079 13.1 6.7 1.3 1 0 0 1 1 1 0 MYND finger PolC_DP2 PF03833.13 EDK40014.1 - 0.078 10.8 1.5 0.089 10.6 1.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Cyclin_N PF00134.23 EDK40015.2 - 1.6e-05 24.6 0.1 2.4e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Frag1 PF10277.9 EDK40016.2 - 7.3e-61 205.5 23.0 7.3e-61 205.5 23.0 1.6 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family Polysacc_synt_C PF14667.6 EDK40016.2 - 0.0059 16.7 3.6 0.0059 16.7 3.6 3.0 4 0 0 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Proton_antipo_C PF01010.19 EDK40016.2 - 0.046 13.3 1.6 0.096 12.3 1.6 1.7 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Ycf70 PF17382.2 EDK40016.2 - 0.72 10.3 5.4 0.13 12.7 0.8 2.1 1 1 1 2 2 2 0 Uncharacterized Ycf70-like DUF3087 PF11286.8 EDK40016.2 - 1 8.8 2.9 2.4 7.6 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) GWT1 PF06423.12 EDK40016.2 - 8.8 6.4 13.0 1.4 9.0 7.1 2.7 2 2 0 2 2 2 0 GWT1 Fungal_trans PF04082.18 EDK40018.2 - 2.9e-13 49.5 0.5 5e-13 48.7 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40018.2 - 1.5e-10 41.1 11.5 2.3e-10 40.4 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 EDK40019.2 - 1.1e-09 38.2 14.4 0.00011 22.4 2.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK40019.2 - 2.1e-08 34.2 17.7 8.7e-05 22.8 4.5 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK40019.2 - 1.9e-05 25.1 11.2 0.021 15.6 1.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EDK40019.2 - 0.025 15.2 1.3 0.12 13.0 0.1 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EDK40019.2 - 0.045 13.8 0.7 5.2 7.2 0.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK40019.2 - 0.077 13.3 1.4 0.22 11.9 0.5 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EDK40019.2 - 0.28 11.5 4.3 0.45 10.8 4.3 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF2225 PF09986.9 EDK40019.2 - 0.32 10.7 0.9 0.74 9.5 0.9 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_5 PF13909.6 EDK40019.2 - 1.5 8.6 13.6 0.92 9.3 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Cyclin_N PF00134.23 EDK40020.2 - 1.9e-07 30.9 0.1 2.7e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDK40020.2 - 0.00093 19.6 0.0 0.0013 19.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin CHZ PF09649.10 EDK40021.1 - 1.5e-19 69.2 1.5 1.5e-19 69.2 1.5 2.4 2 1 0 2 2 2 1 Histone chaperone domain CHZ DUF4746 PF15928.5 EDK40021.1 - 0.43 10.0 12.4 0.6 9.5 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Zip PF02535.22 EDK40021.1 - 0.53 9.4 1.2 0.52 9.5 1.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 EDK40021.1 - 4.1 6.1 8.5 4.5 6.0 8.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 EDK40021.1 - 4.6 6.0 11.4 5.9 5.7 11.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 EDK40021.1 - 5.7 5.6 6.5 5.9 5.5 6.5 1.1 1 0 0 1 1 1 0 Presenilin LSM PF01423.22 EDK40022.1 - 2.7e-15 55.8 0.0 4.1e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 LSM domain Ras PF00071.22 EDK40024.2 - 1.8e-59 200.0 0.1 2.1e-59 199.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40024.2 - 2.2e-34 118.2 0.0 3.3e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK40024.2 - 4.3e-12 45.8 0.0 5.6e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDK40024.2 - 4e-07 30.1 0.0 6.2e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase KAP_NTPase PF07693.14 EDK40024.2 - 0.00098 18.4 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain RsgA_GTPase PF03193.16 EDK40024.2 - 0.0021 18.0 0.5 0.03 14.2 0.1 2.1 1 1 1 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EDK40024.2 - 0.0044 17.3 0.1 0.095 13.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EDK40024.2 - 0.0062 16.1 0.0 0.016 14.7 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDK40024.2 - 0.0064 16.9 0.1 0.012 16.1 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EDK40024.2 - 0.016 15.0 0.0 0.033 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDK40024.2 - 0.021 15.3 0.0 0.031 14.8 0.0 1.6 1 1 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 EDK40024.2 - 0.06 13.2 0.1 0.09 12.7 0.1 1.2 1 0 0 1 1 1 0 NTPase SRPRB PF09439.10 EDK40024.2 - 0.066 12.6 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EDK40024.2 - 0.077 12.7 0.0 0.21 11.4 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EDK40024.2 - 0.11 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 EDK40024.2 - 0.16 11.5 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B SPT16 PF08644.11 EDK40025.2 - 1.4e-46 158.4 4.7 1.7e-46 158.1 0.1 2.7 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EDK40025.2 - 4.9e-40 137.0 0.6 1.8e-39 135.1 0.3 2.2 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EDK40025.2 - 1.7e-28 99.8 0.0 4e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EDK40025.2 - 2.5e-13 50.3 0.0 7.9e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Serglycin PF04360.12 EDK40025.2 - 4.5 7.2 10.3 0.82 9.6 5.6 2.2 2 0 0 2 2 2 0 Serglycin DUF2185 PF09951.9 EDK40025.2 - 6 6.8 7.2 0.92 9.4 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) DNA_primase_lrg PF04104.14 EDK40026.2 - 2e-78 263.5 0.0 2.7e-78 263.1 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit AAA_21 PF13304.6 EDK40026.2 - 0.047 13.5 0.2 0.1 12.4 0.1 1.6 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DpnI_C PF17726.1 EDK40026.2 - 0.52 10.5 4.4 1.2 9.3 0.4 3.1 3 0 0 3 3 3 0 Dam-replacing HTH domain E1-E2_ATPase PF00122.20 EDK40027.2 - 2.3e-19 69.6 0.0 5.3e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EDK40027.2 - 4.9e-17 62.9 0.0 8.4e-10 39.3 0.0 3.2 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDK40027.2 - 1.1e-06 28.6 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDK40027.2 - 0.00097 18.9 0.1 0.0089 15.8 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDK40027.2 - 0.039 13.5 0.1 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Cation_ATPase_N PF00690.26 EDK40027.2 - 0.14 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus CDT1_C PF16679.5 EDK40028.2 - 2.3e-13 50.4 0.0 5.3e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain tRNA-synt_1 PF00133.22 EDK40029.2 - 2.5e-230 765.8 0.1 2.8e-229 762.4 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDK40029.2 - 8.1e-38 129.8 0.1 2.9e-37 128.0 0.1 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDK40029.2 - 4.1e-15 55.4 7.5 1.2e-09 37.5 0.0 4.4 5 1 0 5 5 5 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDK40029.2 - 1.2e-11 44.5 5.1 3.2e-07 30.1 0.0 3.2 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDK40029.2 - 0.0052 16.2 2.8 0.31 10.4 0.0 3.6 4 1 0 4 4 4 1 tRNA synthetases class I (C) catalytic domain NYN_YacP PF05991.11 EDK40029.2 - 0.16 11.9 3.9 0.16 11.9 0.8 2.6 2 0 0 2 2 2 0 YacP-like NYN domain DUF848 PF05852.11 EDK40029.2 - 0.3 11.2 6.7 4.7 7.3 1.5 2.7 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) tRNA-synt_1b PF00579.25 EDK40029.2 - 0.58 9.4 0.0 0.58 9.4 0.0 3.3 4 0 0 4 4 4 0 tRNA synthetases class I (W and Y) Nop PF01798.18 EDK40030.2 - 9.8e-57 192.1 0.0 1.8e-56 191.2 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EDK40030.2 - 3.7e-26 92.4 8.0 3.7e-26 92.4 8.0 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain RNase_PH PF01138.21 EDK40031.1 - 2.3e-15 57.3 0.1 3.2e-15 56.8 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDK40031.1 - 0.0025 17.8 0.0 0.006 16.6 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Pkinase PF00069.25 EDK40032.2 - 6.6e-56 189.6 0.0 2.8e-55 187.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40032.2 - 1.6e-26 93.2 0.0 6.3e-19 68.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EDK40032.2 - 3e-06 27.8 2.5 9.9e-06 26.2 2.3 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 EDK40032.2 - 0.00035 20.0 0.0 0.00098 18.5 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDK40032.2 - 0.00036 19.9 0.0 0.028 13.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK40032.2 - 0.00058 18.9 1.4 0.0026 16.8 0.0 2.4 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EDK40032.2 - 0.0079 16.1 0.0 0.035 14.0 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family VGLL4 PF15245.6 EDK40032.2 - 0.43 10.6 3.2 18 5.3 1.4 2.2 2 0 0 2 2 2 0 Transcription cofactor vestigial-like protein 4 Gpr1_Fun34_YaaH PF01184.19 EDK40033.2 - 2e-90 301.9 24.9 2.4e-90 301.7 24.9 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family CwfJ_C_1 PF04677.15 EDK40034.2 - 1.7e-26 92.4 0.0 5e-26 91.0 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EDK40034.2 - 1.4e-12 48.4 0.1 2.8e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 SET PF00856.28 EDK40035.2 - 1.2e-15 58.3 0.0 2.3e-15 57.4 0.0 1.4 1 1 0 1 1 1 1 SET domain Med15_fungi PF05397.12 EDK40035.2 - 0.036 14.3 0.2 0.057 13.7 0.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 15 zf-FCS PF06467.14 EDK40035.2 - 0.043 13.8 2.9 0.11 12.5 2.9 1.7 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif YHS PF04945.13 EDK40035.2 - 2.2 8.4 8.2 0.16 12.1 0.6 2.8 3 0 0 3 3 3 0 YHS domain AA_permease PF00324.21 EDK40036.1 - 2.8e-120 402.1 40.3 3.5e-120 401.8 40.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40036.1 - 5.3e-36 124.4 38.0 6.4e-36 124.1 38.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK40037.1 - 8.4e-92 308.2 46.4 9.5e-92 308.1 46.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40037.1 - 4.2e-31 108.2 50.7 5.2e-31 107.9 50.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40038.2 - 3.4e-67 227.1 54.5 4.1e-67 226.9 54.5 1.1 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L21e PF01157.18 EDK40039.1 - 2.2e-47 159.1 6.1 2.2e-47 159.1 6.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 EDK40039.1 - 0.00027 20.6 0.0 0.00033 20.3 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 CBF PF03914.17 EDK40040.2 - 2.4e-30 105.8 1.1 2.4e-30 105.8 1.1 1.9 2 0 0 2 2 2 1 CBF/Mak21 family MCM PF00493.23 EDK40041.2 - 2.3e-95 318.0 0.3 4e-95 317.2 0.3 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDK40041.2 - 8.5e-33 112.9 0.0 1.6e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDK40041.2 - 1.9e-23 82.7 1.9 4.7e-23 81.4 1.9 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDK40041.2 - 2.7e-16 60.0 1.1 1.8e-15 57.4 0.2 2.7 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDK40041.2 - 1.3e-07 31.2 0.0 2e-06 27.4 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDK40041.2 - 0.0022 17.8 0.2 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDK40041.2 - 0.0046 16.7 0.0 0.02 14.6 0.0 2.0 1 0 0 1 1 1 1 Sigma-54 interaction domain Symplekin_C PF12295.8 EDK40041.2 - 0.063 13.4 1.4 0.086 12.9 0.2 1.8 2 0 0 2 2 2 0 Symplekin tight junction protein C terminal Methyltransf_15 PF09445.10 EDK40042.2 - 8.5e-49 165.3 0.0 1.1e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EDK40042.2 - 8e-06 26.5 0.0 2.7e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK40042.2 - 5.3e-05 23.1 0.0 7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EDK40042.2 - 0.00046 19.9 0.2 0.0015 18.2 0.1 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EDK40042.2 - 0.00087 18.6 0.0 0.0016 17.7 0.0 1.3 1 1 0 1 1 1 1 N-6 DNA Methylase MTS PF05175.14 EDK40042.2 - 0.0056 16.2 0.0 0.024 14.2 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EDK40042.2 - 0.016 15.9 0.1 0.058 14.0 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EDK40042.2 - 0.038 13.3 0.1 0.07 12.4 0.0 1.4 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EDK40042.2 - 0.054 12.8 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDK40042.2 - 0.065 13.0 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EDK40042.2 - 0.14 12.1 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EDK40042.2 - 0.17 11.6 0.0 0.24 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ASFV_L11L PF05293.11 EDK40043.2 - 0.012 16.0 1.8 0.012 15.9 0.7 1.5 2 0 0 2 2 2 0 African swine fever virus (ASFV) L11L protein GCR1_C PF12550.8 EDK40044.2 - 2.6e-19 69.3 0.1 5.1e-19 68.4 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes NYD-SP28 PF14772.6 EDK40044.2 - 0.57 10.3 5.7 0.12 12.5 1.7 1.8 2 0 0 2 2 2 0 Sperm tail HSP70 PF00012.20 EDK40045.2 - 1.6e-263 875.4 12.4 1.8e-263 875.2 12.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDK40045.2 - 9.2e-16 57.6 4.0 2.8e-14 52.7 1.6 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDK40045.2 - 0.00054 19.7 0.1 0.0017 18.1 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF5321 PF17254.2 EDK40045.2 - 0.017 14.5 1.1 0.04 13.4 1.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5321) MRP-S27 PF10037.9 EDK40045.2 - 0.11 11.3 6.5 0.2 10.5 6.5 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF615 PF04751.14 EDK40045.2 - 0.32 11.0 4.7 0.21 11.6 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF615) FtsA PF14450.6 EDK40045.2 - 0.65 10.4 12.8 0.15 12.5 0.4 4.1 3 3 0 3 3 3 0 Cell division protein FtsA Asp PF00026.23 EDK40047.1 - 1.6e-100 336.6 0.0 2.7e-100 335.8 0.1 1.3 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK40047.1 - 1.4e-14 54.7 0.2 3.1e-12 47.1 0.2 2.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDK40047.1 - 0.00024 21.7 0.0 0.18 12.5 0.0 2.6 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDK40047.1 - 0.00091 19.7 0.0 0.18 12.4 0.0 2.5 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDK40047.1 - 0.042 13.6 0.0 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Abhydrolase_1 PF00561.20 EDK40048.2 - 6.5e-12 45.6 0.0 1.8e-10 40.9 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK40048.2 - 4.4e-09 35.9 0.0 1.6e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK40048.2 - 1.3e-05 25.9 0.0 2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EDK40048.2 - 0.0017 18.2 0.0 0.015 15.1 0.0 2.4 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF676 PF05057.14 EDK40048.2 - 0.0085 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Cutinase PF01083.22 EDK40048.2 - 0.023 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Cutinase UPF0227 PF05728.12 EDK40048.2 - 0.098 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 EDK40048.2 - 0.15 12.0 0.0 0.38 10.6 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) EamA PF00892.20 EDK40049.2 - 1.3e-21 77.2 34.7 7.3e-13 48.9 8.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family Fig1 PF12351.8 EDK40049.2 - 6 6.7 10.6 0.38 10.7 3.0 2.4 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Ras PF00071.22 EDK40050.1 - 6.4e-51 172.2 0.0 7.3e-51 172.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40050.1 - 1.1e-22 80.5 0.0 2.4e-22 79.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK40050.1 - 1.9e-09 37.2 0.0 2.5e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EDK40050.1 - 0.0013 18.5 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EDK40050.1 - 0.031 13.7 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EDK40050.1 - 0.063 13.4 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NST1 PF13945.6 EDK40051.2 - 3.7e-18 66.3 4.4 1.1e-10 42.0 1.8 4.9 4 1 1 5 5 5 2 Salt tolerance down-regulator Ion_trans PF00520.31 EDK40052.2 - 2.1e-07 30.4 18.7 5.4e-07 29.1 18.7 1.6 1 1 0 1 1 1 1 Ion transport protein Frag1 PF10277.9 EDK40053.2 - 1.3e-23 83.7 23.4 1.6e-23 83.4 23.4 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family UPF0182 PF03699.13 EDK40053.2 - 0.2 9.7 9.9 0.25 9.4 9.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Voltage_CLC PF00654.20 EDK40053.2 - 0.21 10.8 14.7 3.2 6.9 12.2 2.1 1 1 1 2 2 2 0 Voltage gated chloride channel DUF4131 PF13567.6 EDK40053.2 - 4.6 6.9 12.0 0.44 10.2 0.5 3.7 1 1 2 4 4 4 0 Domain of unknown function (DUF4131) SUR7 PF06687.12 EDK40053.2 - 6.7 6.3 14.6 17 4.9 14.7 1.7 1 1 0 1 1 1 0 SUR7/PalI family SNF2_N PF00176.23 EDK40055.2 - 2.7e-77 259.8 0.6 5.8e-77 258.8 0.6 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EDK40055.2 - 6.1e-41 139.0 0.4 4.6e-40 136.2 0.4 2.7 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 EDK40055.2 - 6.1e-33 113.9 4.0 6.1e-33 113.9 4.0 3.8 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 EDK40055.2 - 6.3e-20 71.6 0.0 3e-19 69.4 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK40055.2 - 4.5e-10 39.8 0.0 4.5e-10 39.8 0.0 3.2 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK40055.2 - 1.9e-05 24.0 0.0 0.00016 20.9 0.1 2.4 1 1 1 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EDK40055.2 - 0.00011 22.0 0.0 0.00027 20.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EDK40055.2 - 0.0002 20.7 1.8 0.0002 20.7 1.8 2.1 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EDK40055.2 - 0.018 15.0 0.3 0.36 10.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain GSHPx PF00255.19 EDK40056.1 - 2e-36 123.9 0.0 2.6e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EDK40056.1 - 0.0052 16.7 0.0 0.058 13.3 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDK40056.1 - 0.061 13.0 0.1 0.89 9.3 0.1 2.1 1 1 0 1 1 1 0 Redoxin Tn7_TnsC_Int PF11426.8 EDK40057.2 - 3 8.1 4.4 0.73 10.1 0.3 2.1 2 0 0 2 2 2 0 Tn7 transposition regulator TnsC Chs7 PF12271.8 EDK40058.1 - 6.6e-121 403.1 21.5 7.5e-121 402.9 21.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone CPP1-like PF11833.8 EDK40058.1 - 1.7 8.2 14.0 0.063 12.9 1.7 2.9 1 1 2 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like RhoGAP PF00620.27 EDK40059.2 - 1.9e-41 141.4 0.1 5.6e-41 139.9 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 EDK40059.2 - 2.5e-08 34.1 1.0 2.5e-08 34.1 1.0 3.1 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain RolB_RolC PF02027.17 EDK40059.2 - 0.045 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 RolB/RolC glucosidase family DUF4248 PF14053.6 EDK40059.2 - 0.12 12.4 0.2 33 4.6 0.0 3.5 2 1 0 3 3 3 0 Domain of unknown function (DUF4248) CTNNB1_binding PF08347.11 EDK40059.2 - 0.14 12.3 12.4 0.046 13.9 3.9 3.0 2 1 0 3 3 3 0 N-terminal CTNNB1 binding COMPASS-Shg1 PF05205.12 EDK40060.2 - 1.3e-28 99.7 0.9 1.3e-28 99.7 0.9 2.0 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 EF-G-binding_N PF07299.11 EDK40060.2 - 0.018 15.6 0.9 0.15 12.6 0.1 2.5 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DUF5401 PF17380.2 EDK40060.2 - 0.025 12.7 11.1 0.031 12.4 11.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Cullin PF00888.22 EDK40061.2 - 1.8e-79 268.0 15.3 2.7e-79 267.4 15.3 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDK40061.2 - 7.5e-11 41.9 2.7 4e-09 36.4 0.0 3.6 4 0 0 4 4 4 1 Cullin protein neddylation domain TFIIF_beta PF02270.15 EDK40061.2 - 0.0098 16.0 0.1 9.5 6.4 0.0 4.3 3 1 0 3 3 3 1 TFIIF, beta subunit HTH domain HTH_DeoR PF08220.12 EDK40061.2 - 0.016 15.0 0.0 0.044 13.5 0.0 1.7 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 EDK40061.2 - 0.024 14.6 0.1 0.066 13.2 0.1 1.8 1 0 0 1 1 1 0 HTH domain DUF1397 PF07165.11 EDK40061.2 - 0.034 13.6 2.2 0.049 13.1 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1397) Rrf2 PF02082.20 EDK40061.2 - 0.083 13.3 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PP-binding PF00550.25 EDK40062.2 - 9.1e-13 48.4 0.4 1.5e-12 47.7 0.4 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EDK40062.2 - 1.6e-05 25.1 0.5 2.2e-05 24.6 0.5 1.2 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.12 EDK40062.2 - 0.04 14.4 0.3 0.057 13.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Ribosom_S12_S23 PF00164.25 EDK40063.2 - 5.8e-33 112.9 1.3 7.3e-33 112.6 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 EDK40063.2 - 0.077 13.7 0.0 0.19 12.5 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein S12 Mob_synth_C PF06463.13 EDK40063.2 - 0.17 11.8 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C P34-Arc PF04045.14 EDK40064.2 - 1.4e-102 342.5 1.8 1.9e-102 342.1 1.8 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 EDK40064.2 - 0.058 13.0 0.3 0.14 11.8 0.3 1.6 1 1 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) CbiK PF06180.11 EDK40064.2 - 0.075 12.3 0.2 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) Pkinase PF00069.25 EDK40065.2 - 2.6e-60 204.0 0.0 3.4e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40065.2 - 2.9e-38 131.6 0.0 4e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK40065.2 - 2.8e-09 36.7 0.0 4.5e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDK40065.2 - 0.00036 19.7 0.5 0.00053 19.1 0.5 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDK40065.2 - 0.0012 17.7 0.0 0.0019 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Hep_59 PF07052.11 EDK40065.2 - 0.0098 16.6 0.1 0.65 10.8 0.0 2.6 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 Haspin_kinase PF12330.8 EDK40065.2 - 0.026 13.5 0.1 0.042 12.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Ytp1 PF10355.9 EDK40066.2 - 1.3e-104 349.4 8.0 2.2e-104 348.6 8.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDK40066.2 - 2.4e-35 120.5 8.3 2.4e-35 120.5 8.3 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) CD47 PF04549.14 EDK40066.2 - 0.89 9.7 6.9 0.17 12.1 1.0 2.3 2 0 0 2 2 2 0 CD47 transmembrane region DNA_pol_B PF00136.21 EDK40067.2 - 7.1e-96 321.7 0.1 1e-95 321.1 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDK40067.2 - 6.7e-18 64.9 0.5 4.1e-12 45.9 0.1 2.6 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDK40067.2 - 5.5e-09 36.4 11.7 1.5e-08 35.0 11.7 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta SLX9 PF15341.6 EDK40067.2 - 0.052 14.0 5.4 0.13 12.6 5.4 1.6 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF723 PF05265.13 EDK40067.2 - 0.12 12.3 0.0 0.45 10.5 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF723) CDP-OH_P_transf PF01066.21 EDK40068.1 - 5.7e-13 49.4 0.6 5.7e-13 49.4 0.6 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ANAPC5 PF12862.7 EDK40069.2 - 2e-31 107.9 9.0 3.8e-31 107.0 7.5 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.6 EDK40069.2 - 0.00094 19.4 5.6 0.11 12.8 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4924 PF16271.5 EDK40069.2 - 0.0059 16.7 3.5 0.51 10.3 0.3 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF4924) TPR_1 PF00515.28 EDK40069.2 - 0.028 14.2 0.1 0.028 14.2 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK40069.2 - 0.038 14.1 5.3 0.17 12.0 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDK40069.2 - 0.076 13.1 0.1 0.56 10.4 0.1 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDK40069.2 - 0.083 13.5 0.2 13 6.6 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDK40069.2 - 0.41 11.0 4.0 0.74 10.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat RIX1 PF08167.12 EDK40070.2 - 1.6e-40 138.9 2.2 8.7e-40 136.5 0.0 2.9 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis CDC45 PF02724.14 EDK40070.2 - 0.08 11.2 1.9 0.11 10.7 1.9 1.2 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 EDK40070.2 - 0.37 10.5 15.4 0.63 9.7 15.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.13 EDK40070.2 - 5 5.1 10.9 2.8 5.9 7.4 2.1 2 0 0 2 2 2 0 DNA polymerase phi V_ATPase_I PF01496.19 EDK40071.2 - 1.2e-301 1002.6 7.8 2.8e-300 998.0 7.8 2.0 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2649 PF10854.8 EDK40071.2 - 0.36 11.2 6.1 1.3 9.4 6.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2649) U-box PF04564.15 EDK40072.2 - 6.1e-18 64.8 0.3 1.8e-17 63.3 0.0 1.9 2 0 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 EDK40072.2 - 0.0089 16.1 0.1 0.026 14.7 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein DUF1451 PF07295.11 EDK40072.2 - 0.016 15.3 0.2 0.12 12.4 0.1 2.1 1 1 0 1 1 1 0 Zinc-ribbon containing domain zf-Nse PF11789.8 EDK40072.2 - 0.017 14.9 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Seryl_tRNA_N PF02403.22 EDK40072.2 - 0.11 12.7 0.7 0.53 10.5 0.4 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain D5_N PF08706.11 EDK40072.2 - 0.13 12.5 1.6 1.8 8.8 1.6 2.1 1 1 0 1 1 1 0 D5 N terminal like IKI3 PF04762.12 EDK40073.2 - 0 1102.8 1.7 0 1102.5 1.7 1.1 1 0 0 1 1 1 1 IKI3 family IF-2B PF01008.17 EDK40073.2 - 0.5 9.5 4.3 3.7 6.7 0.1 2.8 3 0 0 3 3 3 0 Initiation factor 2 subunit family MIT PF04212.18 EDK40073.2 - 1.3 9.1 4.9 12 6.1 0.3 3.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Rad52_Rad22 PF04098.15 EDK40074.2 - 3.8e-23 82.1 0.0 5.1e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Sugarporin_N PF11471.8 EDK40074.2 - 0.022 14.7 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Uso1_p115_head PF04869.14 EDK40075.2 - 1.5e-101 339.6 5.0 3.6e-101 338.4 0.2 3.8 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EDK40075.2 - 8.7e-13 48.7 28.1 8.7e-13 48.7 28.1 14.3 1 1 14 16 16 11 4 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 EDK40075.2 - 0.00013 22.5 22.1 0.00013 22.5 22.1 14.8 2 1 12 14 14 12 1 Apg6 coiled-coil region GAS PF13851.6 EDK40075.2 - 0.00021 20.7 296.0 0.037 13.4 40.5 11.7 1 1 11 12 12 12 9 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EDK40075.2 - 0.00075 18.5 35.4 0.00075 18.5 35.4 10.3 1 1 12 13 13 13 5 Spc7 kinetochore protein DUF3450 PF11932.8 EDK40075.2 - 0.00091 18.6 10.0 0.00091 18.6 10.0 13.8 1 1 12 14 14 14 3 Protein of unknown function (DUF3450) ATG16 PF08614.11 EDK40075.2 - 0.0017 18.6 285.5 0.024 14.9 28.2 12.3 1 1 8 10 10 10 3 Autophagy protein 16 (ATG16) Arm_vescicular PF18770.1 EDK40075.2 - 0.003 17.4 0.0 0.0093 15.9 0.0 1.8 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Taxilin PF09728.9 EDK40075.2 - 0.0033 16.7 48.5 0.0033 16.7 48.5 7.5 1 1 5 6 6 4 1 Myosin-like coiled-coil protein CENP-H PF05837.12 EDK40075.2 - 0.0082 16.5 12.8 0.0082 16.5 12.8 14.1 2 2 12 14 14 13 2 Centromere protein H (CENP-H) NPV_P10 PF05531.12 EDK40075.2 - 0.0088 16.5 2.1 0.0088 16.5 2.1 15.2 8 6 3 13 13 11 3 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 EDK40075.2 - 0.0095 16.0 3.9 0.0095 16.0 3.9 21.8 12 6 10 24 24 21 3 bZIP transcription factor HEAT_2 PF13646.6 EDK40075.2 - 0.017 15.5 0.2 2.4 8.6 0.0 3.2 2 1 0 2 2 2 0 HEAT repeats DUF3584 PF12128.8 EDK40075.2 - 0.035 11.6 253.1 0.028 11.9 39.9 5.0 1 1 4 5 5 5 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 EDK40075.2 - 1.5 9.3 264.5 0.036 14.5 25.8 9.9 1 1 9 10 10 10 0 Fez1 zf-H2C2_2 PF13465.6 EDK40076.2 - 6.4e-06 26.4 1.3 6.4e-06 26.4 1.3 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDK40076.2 - 7.9e-05 22.9 16.1 0.00087 19.6 5.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK40076.2 - 0.027 15.3 13.5 0.17 12.8 3.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Optomotor-blind PF11078.8 EDK40076.2 - 0.028 15.0 0.1 0.059 13.9 0.1 1.5 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region zf-met PF12874.7 EDK40076.2 - 0.47 10.9 9.1 2.5 8.6 0.8 2.6 2 1 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EDK40076.2 - 1.5 9.5 12.5 0.2 12.3 3.4 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EDK40076.2 - 3.7 7.7 12.0 5.4 7.1 3.5 3.1 2 1 0 2 2 2 0 C2H2-type zinc finger PALP PF00291.25 EDK40077.1 - 7.5e-48 163.4 0.0 8.7e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Xpo1 PF08389.12 EDK40078.2 - 4.6e-32 111.2 12.4 7.6e-32 110.4 0.0 4.3 5 0 0 5 5 5 2 Exportin 1-like protein FAD_SOX PF18371.1 EDK40078.2 - 0.046 14.1 0.2 2.4 8.6 0.0 3.3 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Las1 PF04031.13 EDK40078.2 - 0.19 11.8 0.3 16 5.6 0.0 2.8 2 0 0 2 2 2 0 Las1-like ANAPC4_WD40 PF12894.7 EDK40079.2 - 1.9e-14 53.7 0.0 0.029 14.6 0.0 5.8 2 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK40079.2 - 5.1e-12 46.1 0.5 0.004 17.9 0.0 5.9 5 1 1 6 6 6 3 WD domain, G-beta repeat PD40 PF07676.12 EDK40079.2 - 0.0068 16.3 0.0 2.9 7.9 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 EDK40079.2 - 0.033 13.8 0.3 1.8 8.1 0.3 2.7 2 1 0 2 2 2 0 PQQ-like domain SDA1 PF05285.12 EDK40079.2 - 1.9 7.8 17.8 2.7 7.3 17.8 1.1 1 0 0 1 1 1 0 SDA1 Coiled-coil_56 PF09813.9 EDK40080.2 - 0.028 14.5 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 YL1_C PF08265.11 EDK40080.2 - 0.073 12.9 0.4 0.22 11.3 0.2 1.9 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain KCH PF16944.5 EDK40081.2 - 3.3e-84 282.6 23.4 4.1e-84 282.3 23.4 1.1 1 0 0 1 1 1 1 Fungal potassium channel DUF3453 PF11935.8 EDK40082.2 - 9.3e-48 162.8 0.5 2.2e-47 161.6 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) LIN37 PF15306.6 EDK40082.2 - 0.09 13.0 0.2 0.2 11.9 0.2 1.5 1 0 0 1 1 1 0 LIN37 DSPc PF00782.20 EDK40083.2 - 2.1e-27 95.5 0.2 1.1e-20 73.8 0.1 3.1 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDK40083.2 - 4.3e-06 26.5 0.0 6.6e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Rep_fac_C PF08542.11 EDK40085.2 - 2.1e-17 63.3 0.1 4.5e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EDK40085.2 - 3e-15 56.8 0.0 1.1e-14 55.0 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDK40085.2 - 2.6e-11 43.6 0.0 4.4e-10 39.6 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 EDK40085.2 - 3.3e-08 33.8 0.1 1.8e-07 31.4 0.1 2.2 2 0 0 2 2 2 1 AAA C-terminal domain Rad17 PF03215.15 EDK40085.2 - 1.8e-07 31.3 0.0 3.6e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EDK40085.2 - 2.4e-05 24.1 0.0 7.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EDK40085.2 - 6.8e-05 22.8 0.0 0.00025 20.9 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK40085.2 - 8.5e-05 23.0 0.3 0.0017 18.8 0.0 2.6 2 2 1 3 3 3 1 AAA ATPase domain DNA_pol3_delta PF06144.13 EDK40085.2 - 0.00011 22.0 0.0 0.00026 20.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EDK40085.2 - 0.00015 22.1 0.0 0.0022 18.3 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDK40085.2 - 0.00058 19.6 0.0 0.0042 16.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDK40085.2 - 0.0012 18.3 0.0 0.0083 15.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EDK40085.2 - 0.002 17.3 0.0 0.0035 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EDK40085.2 - 0.0034 17.4 0.0 0.0082 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDK40085.2 - 0.0045 17.0 0.0 0.019 15.0 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDK40085.2 - 0.0058 17.0 0.4 0.14 12.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain DNA_pol3_gamma3 PF12169.8 EDK40085.2 - 0.0058 16.5 0.3 0.016 15.1 0.3 1.8 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III AAA_24 PF13479.6 EDK40085.2 - 0.0063 16.3 0.0 0.014 15.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDK40085.2 - 0.0077 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Peptidase_S66 PF02016.15 EDK40085.2 - 0.0081 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain ABC_tran PF00005.27 EDK40085.2 - 0.022 15.3 0.0 0.5 10.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.14 EDK40085.2 - 0.025 14.6 0.3 0.11 12.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDK40085.2 - 0.038 14.3 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDK40085.2 - 0.039 13.5 0.2 0.19 11.3 0.0 2.3 2 2 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDK40085.2 - 0.042 14.4 0.0 0.18 12.4 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.6 EDK40085.2 - 0.045 14.2 0.0 0.1 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDK40085.2 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase BTB_2 PF02214.22 EDK40086.2 - 0.026 14.9 0.0 0.098 13.0 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain Yae1_N PF09811.9 EDK40087.2 - 3e-13 49.2 1.4 4.4e-13 48.7 1.4 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Phage_int_SAM_5 PF13102.6 EDK40088.2 - 0.025 14.9 0.2 0.059 13.7 0.1 1.7 2 0 0 2 2 2 0 Phage integrase SAM-like domain Vir_act_alpha_C PF10400.9 EDK40088.2 - 0.33 11.7 4.0 1.5 9.6 0.4 2.4 2 0 0 2 2 2 0 Virulence activator alpha C-term NuA4 PF09340.10 EDK40088.2 - 1 9.2 3.7 1 9.3 0.5 2.3 1 1 1 2 2 2 0 Histone acetyltransferase subunit NuA4 PX PF00787.24 EDK40089.2 - 0.0079 16.2 0.2 0.025 14.6 0.1 1.9 2 0 0 2 2 2 1 PX domain PAP2 PF01569.21 EDK40090.2 - 4e-25 88.2 2.8 4e-25 88.2 2.8 1.8 2 0 0 2 2 2 1 PAP2 superfamily DUF4321 PF14209.6 EDK40090.2 - 0.0016 18.2 6.1 0.02 14.7 0.7 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4321) RseC_MucC PF04246.12 EDK40090.2 - 0.044 13.7 1.3 7.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Glucos_trans_II PF14264.6 EDK40090.2 - 0.069 12.5 4.2 0.29 10.4 0.9 2.2 2 0 0 2 2 2 0 Glucosyl transferase GtrII MerC PF03203.14 EDK40090.2 - 0.08 13.4 9.8 0.13 12.7 3.7 2.9 1 1 2 3 3 3 0 MerC mercury resistance protein UPF0014 PF03649.13 EDK40090.2 - 0.12 11.7 4.3 0.21 10.9 0.9 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0014) PAP2_3 PF14378.6 EDK40090.2 - 0.32 10.7 9.4 4.5 6.9 9.4 2.3 1 1 0 1 1 1 0 PAP2 superfamily 7TMR-DISM_7TM PF07695.11 EDK40090.2 - 0.76 9.6 17.7 3.8 7.3 2.2 2.6 2 1 0 2 2 2 0 7TM diverse intracellular signalling Choline_kinase PF01633.20 EDK40091.2 - 8.7e-43 146.4 0.0 6.3e-42 143.6 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EDK40091.2 - 4.3e-07 30.1 0.1 9.9e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family HGTP_anticodon2 PF12745.7 EDK40092.2 - 4.1e-82 275.6 9.8 1.3e-81 273.9 0.5 2.4 2 0 0 2 2 2 2 Anticodon binding domain of tRNAs Pkinase PF00069.25 EDK40092.2 - 1.5e-68 231.0 1.1 5e-38 131.0 0.1 3.6 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40092.2 - 3.1e-41 141.4 0.2 1.3e-19 70.5 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 EDK40092.2 - 6.4e-16 58.7 0.7 6.4e-16 58.7 0.7 2.6 3 0 0 3 3 3 1 RWD domain tRNA-synt_His PF13393.6 EDK40092.2 - 1.4e-08 34.4 0.0 2.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Histidyl-tRNA synthetase Kinase-like PF14531.6 EDK40092.2 - 3.2e-05 23.4 0.0 0.015 14.7 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EDK40092.2 - 3.6e-05 23.2 0.0 0.099 12.0 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Mre11_DNA_bind PF04152.14 EDK40093.2 - 5.5e-42 143.9 0.7 5.5e-42 143.9 0.7 2.3 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EDK40093.2 - 2.4e-11 44.5 0.6 5.5e-11 43.4 0.6 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDK40093.2 - 0.0031 17.7 0.0 0.02 15.1 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ATP11 PF06644.11 EDK40094.2 - 5.5e-86 288.7 10.2 6.3e-86 288.5 10.2 1.0 1 0 0 1 1 1 1 ATP11 protein zf-DNL PF05180.12 EDK40095.1 - 9.4e-32 108.8 0.8 1.5e-31 108.1 0.8 1.3 1 0 0 1 1 1 1 DNL zinc finger TFIIS_C PF01096.18 EDK40095.1 - 0.061 13.2 3.6 1.7 8.5 0.8 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) HypA PF01155.19 EDK40095.1 - 0.15 12.1 0.4 0.24 11.5 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 EDK40095.1 - 0.19 11.6 5.5 1.8 8.5 6.1 2.2 1 1 1 2 2 2 0 zinc-ribbon domain zf-C3HC4_3 PF13920.6 EDK40096.2 - 1.6e-06 27.9 7.8 1.6e-06 27.9 7.8 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Colicin_immun PF09204.10 EDK40096.2 - 0.13 12.8 1.9 1.7 9.2 0.2 2.7 2 0 0 2 2 2 0 Bacterial self-protective colicin-like immunity zf-C2H2_4 PF13894.6 EDK40096.2 - 0.28 12.1 0.2 0.28 12.1 0.2 7.4 7 1 0 7 7 7 0 C2H2-type zinc finger zf-RING_UBOX PF13445.6 EDK40096.2 - 3.4 7.8 8.4 14 5.8 8.4 2.2 1 0 0 1 1 1 0 RING-type zinc-finger PGP_phosphatase PF09419.10 EDK40097.2 - 9.1e-70 233.6 0.1 1.1e-69 233.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EDK40097.2 - 5.2e-06 26.4 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Glycos_transf_2 PF00535.26 EDK40097.2 - 0.069 13.0 0.1 0.14 11.9 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 2 PI3_PI4_kinase PF00454.27 EDK40098.1 - 1.3e-37 130.0 0.0 2e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EDK40098.1 - 3.1e-06 26.9 0.1 3.1e-06 26.9 0.1 1.7 2 0 0 2 2 2 1 FATC domain AAA_32 PF13654.6 EDK40098.1 - 0.039 12.7 0.0 0.069 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF365 PF04033.12 EDK40098.1 - 0.11 12.7 0.0 0.34 11.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF365) M60-like_N PF17291.2 EDK40099.2 - 0.17 11.8 0.0 0.43 10.5 0.0 1.6 1 1 1 2 2 2 0 N-terminal domain of M60-like peptidases FAT PF02259.23 EDK40100.1 - 2.7e-77 260.4 6.0 2.7e-77 260.4 6.0 1.6 2 0 0 2 2 2 1 FAT domain TPR_8 PF13181.6 EDK40100.1 - 0.17 12.2 2.7 5.4 7.5 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDK40100.1 - 2.5 8.4 5.0 31 5.0 0.9 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat NUC194 PF08163.12 EDK40102.2 - 0.00015 20.8 0.9 0.001 18.1 0.1 2.3 2 0 0 2 2 2 1 NUC194 domain Sec7_N PF12783.7 EDK40102.2 - 0.0003 20.7 1.5 0.13 12.1 0.0 4.3 4 1 1 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3932 PF13068.6 EDK40102.2 - 0.009 16.3 0.1 0.14 12.4 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3932) DUF5449 PF17528.2 EDK40102.2 - 0.048 13.4 0.1 0.37 10.5 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5449) Acyltransferase PF01553.21 EDK40103.2 - 0.0013 18.4 0.0 0.002 17.7 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Aldo_ket_red PF00248.21 EDK40104.2 - 4.7e-60 203.3 0.1 6.5e-60 202.8 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ABC2_membrane PF01061.24 EDK40105.2 - 2.6e-82 275.3 56.3 4e-44 150.5 18.8 3.3 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EDK40105.2 - 4e-39 134.2 0.0 9.2e-20 71.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EDK40105.2 - 2.9e-36 123.2 3.8 5.4e-30 103.1 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter RsgA_GTPase PF03193.16 EDK40105.2 - 6.1e-07 29.5 0.4 2.9e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EDK40105.2 - 8.3e-05 23.0 0.1 0.0017 18.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EDK40105.2 - 9.2e-05 22.1 0.2 0.00031 20.4 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDK40105.2 - 0.0002 22.0 1.3 0.035 14.6 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EDK40105.2 - 0.00065 19.4 0.5 0.11 12.3 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EDK40105.2 - 0.0025 18.1 0.7 0.03 14.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EDK40105.2 - 0.0025 17.3 0.0 0.17 11.3 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EDK40105.2 - 0.0026 18.3 0.0 0.18 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EDK40105.2 - 0.0045 16.8 0.2 1.9 8.2 0.0 3.3 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EDK40105.2 - 0.005 16.9 0.2 0.53 10.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDK40105.2 - 0.0062 16.8 0.5 0.15 12.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDK40105.2 - 0.015 15.4 0.1 0.81 9.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EDK40105.2 - 0.022 14.7 3.6 1.1 9.2 0.0 3.2 4 0 0 4 4 4 0 NACHT domain AAA_30 PF13604.6 EDK40105.2 - 0.023 14.4 0.1 0.97 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDK40105.2 - 0.031 14.0 0.0 0.84 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EDK40105.2 - 0.038 13.9 0.0 1.3 8.8 0.0 2.8 3 0 0 3 3 3 0 Deoxynucleoside kinase NTPase_1 PF03266.15 EDK40105.2 - 0.079 12.9 0.9 4.1 7.3 0.1 3.0 3 0 0 3 3 3 0 NTPase cobW PF02492.19 EDK40105.2 - 0.14 11.7 2.1 2.2 7.8 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EDK40105.2 - 0.26 11.7 3.4 6.8 7.1 0.0 3.2 3 1 0 3 3 2 0 AAA domain ABC2_membrane_3 PF12698.7 EDK40105.2 - 8 5.5 42.1 0.014 14.6 13.3 3.1 2 2 0 2 2 1 0 ABC-2 family transporter protein Coprogen_oxidas PF01218.18 EDK40106.2 - 6.2e-136 451.9 0.0 7.1e-136 451.7 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase CorA PF01544.18 EDK40107.2 - 9.9e-42 143.2 0.3 2.2e-25 89.6 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein MAP17 PF15807.5 EDK40107.2 - 0.065 13.5 0.0 0.065 13.5 0.0 2.9 3 1 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SWIRM-assoc_1 PF16495.5 EDK40107.2 - 0.2 11.7 1.4 0.41 10.6 1.4 1.4 1 0 0 1 1 1 0 SWIRM-associated region 1 Tn7_Tnp_TnsA_N PF08722.11 EDK40107.2 - 0.26 11.5 1.7 2.1 8.6 0.1 2.9 3 0 0 3 3 3 0 TnsA endonuclease N terminal AAA_6 PF12774.7 EDK40108.2 - 8.5e-103 343.8 0.1 3.7e-102 341.6 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EDK40108.2 - 2.3e-79 267.3 14.5 2.3e-79 267.3 14.5 5.6 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EDK40108.2 - 3.7e-53 179.9 1.4 3.7e-53 179.9 1.4 3.8 4 0 0 4 4 4 1 ATP-binding dynein motor region DHC_N1 PF08385.12 EDK40108.2 - 2.1e-44 152.1 7.6 2.1e-44 152.1 7.6 4.4 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 EDK40108.2 - 3.2e-40 138.1 0.2 5.3e-38 130.8 0.0 3.2 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EDK40108.2 - 1.1e-36 126.1 0.0 2.2e-32 112.0 0.0 4.4 5 0 0 5 5 4 1 P-loop containing dynein motor region MT PF12777.7 EDK40108.2 - 3.9e-31 108.3 5.1 4.9e-30 104.7 4.6 2.3 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EDK40108.2 - 5.7e-28 97.6 0.0 5e-09 36.3 0.0 5.6 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EDK40108.2 - 3e-20 72.5 0.7 1.7e-19 70.1 0.0 2.8 2 0 0 2 2 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EDK40108.2 - 2e-19 70.0 0.0 5.5e-19 68.6 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EDK40108.2 - 2.1e-11 44.4 0.0 0.0061 17.0 0.0 5.4 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDK40108.2 - 1.2e-09 38.8 0.0 0.062 13.8 0.0 5.3 4 0 0 4 4 4 2 AAA domain Dynein_AAA_lid PF17852.1 EDK40108.2 - 6e-09 36.1 0.8 2.6e-08 34.0 0.8 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EDK40108.2 - 7.5e-09 36.0 2.3 0.076 13.3 0.0 7.3 8 0 0 8 8 6 1 AAA domain AAA_16 PF13191.6 EDK40108.2 - 2.9e-06 27.8 0.0 1.5 9.2 0.0 5.6 4 0 0 4 4 4 1 AAA ATPase domain T2SSE PF00437.20 EDK40108.2 - 3.8e-05 22.9 0.0 0.16 11.0 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_33 PF13671.6 EDK40108.2 - 0.00036 20.7 3.0 0.69 10.1 0.0 5.3 6 0 0 6 6 5 1 AAA domain BRE1 PF08647.11 EDK40108.2 - 0.0016 18.5 1.6 0.0016 18.5 1.6 4.8 5 0 0 5 5 3 1 BRE1 E3 ubiquitin ligase AAA_lid_1 PF17857.1 EDK40108.2 - 0.0077 16.4 0.0 0.095 12.9 0.0 2.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_25 PF13481.6 EDK40108.2 - 0.013 15.1 0.0 0.17 11.4 0.0 3.0 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 EDK40108.2 - 0.015 14.7 0.2 2 7.7 0.0 3.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDK40108.2 - 0.015 15.6 0.8 0.73 10.2 0.0 3.8 3 1 1 4 4 3 0 AAA domain IstB_IS21 PF01695.17 EDK40108.2 - 0.016 14.9 0.1 0.51 10.1 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 EDK40108.2 - 0.026 14.3 0.1 33 4.1 0.0 4.0 5 0 0 5 5 5 0 AAA domain AAA_lid_7 PF17867.1 EDK40108.2 - 0.052 13.8 0.1 0.052 13.8 0.1 3.6 4 0 0 4 4 2 0 Midasin AAA lid domain AAA_24 PF13479.6 EDK40108.2 - 0.12 12.1 0.2 34 4.1 0.0 3.7 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 EDK40108.2 - 0.15 12.0 2.9 13 5.7 0.0 4.0 4 0 0 4 4 3 0 NACHT domain AAA_11 PF13086.6 EDK40108.2 - 0.56 9.9 0.0 0.56 9.9 0.0 4.3 4 0 0 4 4 4 0 AAA domain Med28 PF11594.8 EDK40108.2 - 2.8 8.0 6.7 1.7 8.7 0.2 3.8 3 0 0 3 3 3 0 Mediator complex subunit 28 Ribosomal_S19e PF01090.19 EDK40109.1 - 9.3e-54 180.8 0.1 1.1e-53 180.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e F-box-like PF12937.7 EDK40110.2 - 0.013 15.4 0.0 0.048 13.6 0.0 2.0 1 1 0 1 1 1 0 F-box-like Prefoldin PF02996.17 EDK40112.2 - 6.2e-31 106.8 4.0 7.2e-31 106.6 4.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EDK40112.2 - 0.0048 16.8 7.7 0.026 14.5 0.3 2.2 1 1 1 2 2 2 2 Prefoldin subunit Tsi6 PF18660.1 EDK40112.2 - 0.026 14.6 1.4 0.04 14.0 0.1 2.0 2 1 0 2 2 2 0 Tsi6 KxDL PF10241.9 EDK40112.2 - 0.036 14.3 3.0 0.26 11.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein Rx_N PF18052.1 EDK40112.2 - 0.1 12.9 0.7 0.1 12.9 0.7 2.2 2 0 0 2 2 2 0 Rx N-terminal domain End3 PF12761.7 EDK40112.2 - 0.11 12.6 7.0 9.2 6.4 7.0 2.1 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SlyX PF04102.12 EDK40112.2 - 0.14 12.8 3.0 0.26 12.0 0.1 2.5 2 1 1 3 3 3 0 SlyX Syntaxin-6_N PF09177.11 EDK40112.2 - 0.49 11.0 5.7 0.42 11.2 1.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal XhlA PF10779.9 EDK40112.2 - 0.55 10.5 5.9 1.6 9.0 0.3 2.4 2 0 0 2 2 2 0 Haemolysin XhlA DUF724 PF05266.14 EDK40112.2 - 1.7 8.5 7.9 1.8 8.3 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Thi4 PF01946.17 EDK40113.2 - 6.2e-114 379.1 0.0 7.4e-114 378.8 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EDK40113.2 - 2.2e-07 30.8 1.7 9.8e-07 28.7 0.9 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK40113.2 - 3.7e-07 29.6 2.2 0.00011 21.4 0.8 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDK40113.2 - 3.9e-07 30.2 0.1 2.2e-06 27.8 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK40113.2 - 1.6e-06 27.6 0.0 1.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDK40113.2 - 7.3e-06 25.3 0.4 1.3e-05 24.5 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EDK40113.2 - 0.00026 21.0 0.2 0.00078 19.5 0.1 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EDK40113.2 - 0.0027 17.1 0.1 0.0038 16.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDK40113.2 - 0.0037 16.0 0.4 0.006 15.3 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EDK40113.2 - 0.0051 16.1 0.1 0.0076 15.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EDK40113.2 - 0.0081 15.3 0.6 0.023 13.8 0.3 1.8 2 1 1 3 3 3 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EDK40113.2 - 0.018 13.9 0.3 0.025 13.4 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EDK40113.2 - 0.024 13.9 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UPF0020 PF01170.18 EDK40114.2 - 3.2e-10 40.0 0.0 1.3e-08 34.8 0.0 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EDK40114.2 - 0.00032 20.5 0.1 0.037 13.7 0.1 2.5 2 2 0 2 2 2 2 DNA methylase N6_Mtase PF02384.16 EDK40114.2 - 0.00054 19.3 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase MethyltransfD12 PF02086.15 EDK40114.2 - 0.14 11.8 3.1 0.81 9.3 0.1 2.6 2 1 1 3 3 3 0 D12 class N6 adenine-specific DNA methyltransferase RRM_1 PF00076.22 EDK40115.2 - 6e-34 115.7 0.4 6.2e-16 58.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK40115.2 - 6.9e-13 48.5 0.4 9.9e-07 28.8 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EDK40115.2 - 0.00031 20.7 0.1 0.13 12.3 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 EDK40115.2 - 0.0071 16.3 0.0 3.5 7.6 0.0 2.5 2 0 0 2 2 2 2 RL domain Nup35_RRM PF05172.13 EDK40115.2 - 0.029 14.3 0.2 0.92 9.5 0.0 2.4 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EDK40115.2 - 0.063 13.0 0.4 8.8 6.1 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Pept_S41_N PF18294.1 EDK40115.2 - 2.3 8.3 6.1 3.2 7.8 4.5 2.0 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain DEAD PF00270.29 EDK40116.2 - 4.9e-50 169.7 0.1 1.3e-48 165.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK40116.2 - 9.8e-23 80.6 1.0 4e-22 78.7 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EDK40116.2 - 4.9e-18 65.1 7.4 4.9e-18 65.1 7.4 2.4 2 0 0 2 2 2 1 DBP10CT (NUC160) domain ResIII PF04851.15 EDK40116.2 - 2.6e-08 34.1 0.0 1.3e-07 31.8 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDK40116.2 - 0.0015 17.8 0.0 0.005 16.1 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase IMPDH PF00478.25 EDK40117.2 - 6.5e-134 446.3 3.9 7.6e-134 446.1 3.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EDK40117.2 - 5.9e-13 49.1 0.1 5.3e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EDK40117.2 - 2e-09 37.3 0.6 1.1e-05 25.0 0.7 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EDK40117.2 - 2.6e-07 30.0 3.3 1.5e-06 27.5 3.3 2.1 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EDK40117.2 - 4.4e-05 23.1 0.7 0.00014 21.4 0.7 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 EDK40117.2 - 0.00063 19.1 2.1 0.0016 17.8 0.4 2.0 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 EDK40117.2 - 0.0078 15.4 0.1 0.017 14.4 0.1 1.5 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Aldolase PF01081.19 EDK40117.2 - 0.015 14.7 0.1 0.05 13.0 0.1 1.9 1 0 0 1 1 1 0 KDPG and KHG aldolase SNRNP27 PF08648.12 EDK40117.2 - 0.12 12.4 0.2 0.27 11.3 0.2 1.6 1 0 0 1 1 1 0 U4/U6.U5 small nuclear ribonucleoproteins YpsA PF06908.11 EDK40117.2 - 0.21 11.6 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family Clat_adaptor_s PF01217.20 EDK40118.2 - 2.2e-53 180.0 2.3 2.7e-53 179.7 2.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Mannosyl_trans3 PF11051.8 EDK40119.2 - 1.7e-83 280.2 0.0 2.3e-83 279.7 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_15 PF01793.16 EDK40120.2 - 7.2e-106 354.1 11.1 9e-106 353.8 11.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TraD_N PF12615.8 EDK40120.2 - 7.6 7.4 6.3 8.4 7.2 0.4 3.3 4 0 0 4 4 4 0 F sex factor protein N terminal IPK PF03770.16 EDK40121.2 - 1.4e-54 184.9 0.0 3.2e-54 183.8 0.0 1.6 2 0 0 2 2 2 1 Inositol polyphosphate kinase HCMVantigenic_N PF12154.8 EDK40121.2 - 0.0068 16.5 1.1 0.0068 16.5 1.1 2.1 2 0 0 2 2 2 1 Glycoprotein B N-terminal antigenic domain of HCMV ADH_N PF08240.12 EDK40122.2 - 2.6e-27 94.9 1.1 2.6e-27 94.9 1.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK40122.2 - 1.3e-19 70.4 0.0 2.2e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK40122.2 - 3e-10 40.0 0.2 4.4e-10 39.4 0.2 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 EDK40122.2 - 0.011 16.0 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 EDK40122.2 - 0.082 13.5 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EDK40122.2 - 0.11 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FMN_red PF03358.15 EDK40123.2 - 1.4e-12 47.6 0.0 2.1e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EDK40123.2 - 6.3e-07 29.3 0.0 9.7e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EDK40123.2 - 5.8e-05 23.3 0.1 0.00012 22.4 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EDK40123.2 - 0.00045 20.5 0.0 0.038 14.2 0.0 2.4 1 1 1 2 2 2 2 Flavodoxin domain FMN_red PF03358.15 EDK40124.2 - 2.9e-12 46.6 0.0 3.6e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EDK40124.2 - 2.3e-06 27.9 0.1 6e-06 26.5 0.1 1.8 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.17 EDK40124.2 - 3.7e-06 26.8 0.0 4.7e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EDK40124.2 - 0.0068 16.6 0.0 0.063 13.5 0.0 2.1 1 1 0 1 1 1 1 Flavodoxin domain PNP_phzG_C PF10590.9 EDK40125.2 - 3.3e-18 65.5 1.6 8.1e-18 64.2 1.6 1.7 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EDK40125.2 - 2.1e-14 53.5 0.0 3.2e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Cupin_8 PF13621.6 EDK40126.2 - 9.9e-13 48.4 0.1 2.8e-12 46.9 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EDK40126.2 - 4.1e-09 36.9 0.7 9.9e-05 22.7 0.1 2.6 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.7 EDK40126.2 - 5.5e-06 26.2 0.0 2.2e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 F-box-like Cupin_2 PF07883.11 EDK40126.2 - 0.053 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Cupin domain GPI PF06560.11 EDK40126.2 - 0.11 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Ribosomal_L32p PF01783.23 EDK40127.2 - 4.5e-15 55.6 1.3 4.5e-15 55.6 1.3 1.9 2 0 0 2 2 2 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 EDK40127.2 - 0.018 14.4 1.3 0.03 13.7 1.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Septin PF00735.18 EDK40128.2 - 1.9e-108 362.1 0.2 2.2e-108 361.8 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDK40128.2 - 7.8e-09 35.6 0.0 1.3e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDK40128.2 - 5.5e-07 29.1 0.4 1.2e-06 28.0 0.4 1.8 1 1 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EDK40128.2 - 1.2e-06 28.5 0.8 2.8e-06 27.4 0.2 1.8 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EDK40128.2 - 4.2e-06 26.4 0.0 0.00053 19.6 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDK40128.2 - 0.00017 21.7 1.8 0.41 10.7 0.6 2.5 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 EDK40128.2 - 0.0016 18.8 0.1 0.0025 18.2 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 EDK40128.2 - 0.0018 17.6 0.1 0.14 11.4 0.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region NB-ARC PF00931.22 EDK40128.2 - 0.0025 17.1 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EDK40128.2 - 0.0043 17.6 0.6 0.0082 16.7 0.6 1.7 1 1 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.18 EDK40128.2 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_22 PF13401.6 EDK40128.2 - 0.011 16.0 0.3 0.034 14.4 0.1 2.1 2 1 0 2 2 2 0 AAA domain IIGP PF05049.13 EDK40128.2 - 0.013 14.6 0.2 0.027 13.5 0.2 1.5 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_14 PF13173.6 EDK40128.2 - 0.018 15.1 0.1 0.067 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EDK40128.2 - 0.019 15.2 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EDK40128.2 - 0.033 13.9 0.1 0.069 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EDK40128.2 - 0.044 13.3 0.0 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 EDK40128.2 - 0.077 12.5 0.4 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EDK40128.2 - 0.1 12.3 0.2 1.7 8.4 0.2 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EDK40128.2 - 0.12 12.1 0.0 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Glyco_transf_8 PF01501.20 EDK40129.2 - 9e-26 91.0 0.0 4.5e-25 88.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EDK40129.2 - 5.9e-06 25.8 0.0 1.2e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Mannosyltransferase putative Myb_DNA-binding PF00249.31 EDK40130.2 - 0.00017 21.7 0.2 0.54 10.5 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK40130.2 - 0.0005 20.3 1.7 0.53 10.6 0.1 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain HTH_7 PF02796.15 EDK40130.2 - 0.14 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MFS_1 PF07690.16 EDK40131.2 - 3.1e-31 108.6 22.1 3.1e-31 108.6 21.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sec3-PIP2_bind PF15277.6 EDK40131.2 - 0.068 13.3 1.6 0.91 9.7 0.1 2.8 2 1 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH DUF4131 PF13567.6 EDK40131.2 - 0.54 9.9 7.5 3.7 7.2 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) MtrD PF04207.12 EDK40131.2 - 1.3 8.6 12.6 5.7 6.6 7.9 2.9 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit D ThiF PF00899.21 EDK40132.2 - 2.2e-109 364.5 0.0 5.7e-76 255.1 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EDK40132.2 - 2.9e-89 299.3 0.1 4.7e-89 298.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EDK40132.2 - 1.1e-35 122.2 0.0 2.5e-35 121.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 EDK40132.2 - 1.9e-27 95.3 0.0 5.4e-27 93.8 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EDK40132.2 - 5e-24 84.3 2.2 1.4e-23 82.8 2.2 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle ABC_membrane PF00664.23 EDK40133.2 - 8.4e-80 268.3 42.7 2.3e-46 158.7 18.0 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK40133.2 - 2.2e-56 190.2 0.0 2.4e-31 109.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK40133.2 - 3.1e-15 56.2 0.0 0.00015 21.3 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDK40133.2 - 2.7e-07 30.2 0.8 0.03 14.1 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDK40133.2 - 2e-06 27.8 0.1 0.039 13.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EDK40133.2 - 4.6e-05 23.4 1.2 2.4 7.9 0.2 4.1 2 2 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDK40133.2 - 4.8e-05 23.7 1.5 0.3 11.3 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 EDK40133.2 - 9.2e-05 23.0 1.7 0.49 10.9 0.1 3.1 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.6 EDK40133.2 - 0.0002 21.5 0.2 0.53 10.5 0.0 3.4 3 1 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EDK40133.2 - 0.00087 19.7 0.0 2 8.8 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 EDK40133.2 - 0.0033 18.0 0.3 11 6.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EDK40133.2 - 0.0061 16.6 0.7 0.26 11.4 0.2 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EDK40133.2 - 0.011 16.1 0.2 6.3 7.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ABC_ATPase PF09818.9 EDK40133.2 - 0.012 14.5 0.2 0.27 10.0 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF3938 PF13074.6 EDK40133.2 - 0.026 14.7 3.4 0.028 14.7 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF3938) NB-ARC PF00931.22 EDK40133.2 - 0.043 13.0 0.8 2.5 7.2 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 EDK40133.2 - 0.062 12.9 0.0 7.2 6.2 0.0 3.0 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 EDK40133.2 - 0.063 13.4 1.1 13 6.0 0.2 2.5 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EDK40133.2 - 0.072 12.8 0.1 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EDK40133.2 - 0.072 13.2 2.3 0.67 10.0 0.2 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 EDK40133.2 - 0.096 12.7 0.3 9.6 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EDK40133.2 - 0.11 12.2 0.1 21 4.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDK40133.2 - 0.12 12.0 0.1 5.2 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EDK40133.2 - 0.12 12.3 0.6 16 5.4 0.0 3.2 3 0 0 3 3 3 0 Rad17 P-loop domain DUF3987 PF13148.6 EDK40133.2 - 0.13 11.3 0.0 4.5 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) PRK PF00485.18 EDK40133.2 - 0.14 11.9 0.5 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 EDK40133.2 - 0.15 12.0 0.6 22 4.9 0.0 2.6 2 0 0 2 2 2 0 NACHT domain Fungal_trans_2 PF11951.8 EDK40134.2 - 1e-10 41.0 0.4 1e-10 41.0 0.4 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40134.2 - 4.7e-06 26.6 14.4 9e-06 25.7 14.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Brr6_like_C_C PF10104.9 EDK40135.2 - 1.8e-44 150.7 1.5 2.4e-44 150.3 1.5 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF501 PF04417.12 EDK40135.2 - 0.06 13.1 0.1 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF501) SKG6 PF08693.10 EDK40135.2 - 0.37 10.2 5.1 4.2 6.9 4.1 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain UDG PF03167.19 EDK40136.1 - 6.9e-10 39.1 0.1 2.4e-09 37.4 0.1 1.8 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily GST_N PF02798.20 EDK40136.1 - 0.03 14.6 0.4 2.8 8.4 0.0 3.0 1 1 2 3 3 3 0 Glutathione S-transferase, N-terminal domain TFB6 PF17110.5 EDK40138.2 - 3.6e-15 56.1 0.1 3.6e-15 56.1 0.1 2.3 2 1 0 2 2 2 1 Subunit 11 of the general transcription factor TFIIH SAM_KSR1 PF13543.6 EDK40138.2 - 0.21 11.7 1.8 3.6 7.7 0.0 2.4 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 Vac_ImportDeg PF09783.9 EDK40139.2 - 1.5e-54 184.2 0.2 2e-54 183.8 0.2 1.2 1 0 0 1 1 1 1 Vacuolar import and degradation protein PEMT PF04191.13 EDK40140.1 - 5e-35 120.1 2.7 8.4e-35 119.4 2.7 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase Sacchrp_dh_C PF16653.5 EDK40141.2 - 2.6e-94 316.2 0.0 3.4e-94 315.8 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Tubulin_3 PF14881.6 EDK40142.2 - 1.2e-24 87.0 0.2 2.1e-24 86.2 0.2 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EDK40142.2 - 1.5e-13 51.1 0.0 1.1e-12 48.3 0.0 2.4 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EDK40142.2 - 0.0069 16.6 0.0 0.022 14.9 0.0 1.8 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain LuxQ-periplasm PF09308.10 EDK40142.2 - 0.031 13.8 0.5 0.069 12.6 0.5 1.5 1 0 0 1 1 1 0 LuxQ, periplasmic DnaJ PF00226.31 EDK40143.2 - 3.1e-25 88.1 2.3 4.6e-25 87.5 2.3 1.2 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EDK40143.2 - 4.4e-16 59.3 0.0 6.2e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDK40143.2 - 2.4e-12 47.0 16.3 4.1e-12 46.3 16.3 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDK40143.2 - 0.15 12.1 16.4 0.06 13.3 2.2 2.8 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDK40143.2 - 0.15 12.1 5.6 5.1 7.2 0.4 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Transferrin PF00405.17 EDK40143.2 - 2 7.5 3.6 1.6 7.8 0.3 2.0 1 1 1 2 2 2 0 Transferrin DZR PF12773.7 EDK40143.2 - 2.3 8.3 10.3 15 5.7 10.3 2.0 1 1 0 1 1 1 0 Double zinc ribbon HMG_CoA_synt_C PF08540.10 EDK40145.2 - 1.1e-107 359.8 4.1 1.5e-107 359.4 4.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EDK40145.2 - 2.7e-92 307.4 1.0 3.4e-92 307.1 0.3 1.5 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Ish1 PF10281.9 EDK40146.2 - 8.5e-35 118.8 28.7 3.2e-08 33.7 1.6 7.9 7 0 0 7 7 7 6 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EDK40146.2 - 4.6e-06 26.2 9.6 0.22 11.3 0.2 5.5 7 0 0 7 7 7 3 HeH/LEM domain Apolipoprotein PF01442.18 EDK40146.2 - 1.8e-05 24.7 10.4 0.04 13.8 6.9 3.5 2 1 1 3 3 3 2 Apolipoprotein A1/A4/E domain DUF1027 PF06265.11 EDK40146.2 - 0.095 12.7 2.5 1.3 9.0 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1027) ApoLp-III PF07464.11 EDK40146.2 - 0.15 12.2 23.1 3.3 7.8 8.8 5.0 2 1 3 5 5 5 0 Apolipophorin-III precursor (apoLp-III) Slx4 PF09494.10 EDK40146.2 - 0.16 11.9 1.3 20 5.2 0.0 3.5 4 0 0 4 4 4 0 Slx4 endonuclease DUF883 PF05957.13 EDK40146.2 - 0.24 12.0 25.3 4.7 7.9 5.3 6.1 3 1 4 7 7 7 0 Bacterial protein of unknown function (DUF883) DUF357 PF04010.13 EDK40146.2 - 2.3 8.3 14.0 2.5 8.3 0.6 5.1 4 1 0 4 4 4 0 Protein of unknown function (DUF357) Chlorosome_CsmC PF11098.8 EDK40146.2 - 3.2 7.7 13.4 0.58 10.1 3.9 3.1 1 1 1 2 2 2 0 Chlorosome envelope protein C Helicase_IV_N PF12462.8 EDK40146.2 - 3.2 7.7 6.9 3 7.8 0.1 3.5 4 0 0 4 4 4 0 DNA helicase IV / RNA helicase N terminal Tubulin_C PF03953.17 EDK40147.1 - 5e-50 168.9 0.1 8.1e-50 168.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 EDK40147.1 - 1.8e-42 145.8 0.0 3.2e-42 145.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EDK40147.1 - 0.0072 16.0 0.0 0.037 13.7 0.0 2.1 2 0 0 2 2 2 1 Tubulin domain NAD_binding_1 PF00175.21 EDK40148.2 - 2.7e-28 98.8 0.0 4.1e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDK40148.2 - 2.9e-28 98.1 0.0 4.6e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDK40148.2 - 2.4e-05 24.5 0.0 0.00072 19.7 0.1 2.2 1 1 1 2 2 2 1 Ferric reductase NAD binding domain zf-CCCH PF00642.24 EDK40149.2 - 1.8e-09 37.2 13.2 0.00016 21.5 3.1 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK40149.2 - 0.00011 22.1 15.1 0.0019 18.2 2.2 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EDK40149.2 - 0.0062 17.2 2.0 0.14 12.9 0.3 3.6 3 1 0 3 3 3 2 Torus domain zf-CCCH_3 PF15663.5 EDK40149.2 - 0.02 15.1 1.0 3.6 7.8 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 EDK40149.2 - 0.4 10.6 13.5 1.1 9.1 1.8 2.4 2 0 0 2 2 2 0 CCCH-type zinc finger DUF2252 PF10009.9 EDK40149.2 - 0.62 9.1 7.7 0.95 8.5 7.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) TrbI_Ftype PF09677.10 EDK40149.2 - 0.87 9.9 3.3 0.69 10.3 1.8 1.6 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) Cation_efflux PF01545.21 EDK40150.2 - 4.6e-45 153.8 5.6 1e-44 152.6 5.6 1.6 1 1 0 1 1 1 1 Cation efflux family CLU PF13236.6 EDK40151.2 - 4.4e-77 258.9 0.0 9.4e-77 257.8 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EDK40151.2 - 4.3e-50 170.2 0.1 4.3e-50 170.2 0.1 1.9 2 0 0 2 2 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 EDK40151.2 - 2.8e-21 75.7 0.4 1.1e-20 73.7 0.4 2.2 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 EDK40151.2 - 3.9e-17 62.3 0.1 5.7e-08 32.9 0.3 3.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDK40151.2 - 1.7e-07 30.9 0.0 0.19 11.7 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDK40151.2 - 1.5e-05 24.8 1.3 0.8 10.0 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDK40151.2 - 0.005 16.6 0.8 14 5.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDK40151.2 - 0.019 15.5 0.0 2 9.0 0.0 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat PPL5 PF18168.1 EDK40151.2 - 0.037 13.3 1.4 0.12 11.6 1.4 1.8 1 0 0 1 1 1 0 Prim-pol family 5 TPR_MalT PF17874.1 EDK40151.2 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region ANAPC3 PF12895.7 EDK40151.2 - 0.13 12.5 0.4 1.7 9.0 0.0 3.1 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Nucleoside_tran PF01733.18 EDK40151.2 - 0.18 11.1 0.2 0.35 10.2 0.2 1.4 1 0 0 1 1 1 0 Nucleoside transporter TPR_7 PF13176.6 EDK40151.2 - 0.19 11.8 0.4 49 4.3 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF4820 PF16091.5 EDK40151.2 - 0.22 10.8 3.3 0.77 9.1 3.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TRAP_alpha PF03896.16 EDK40151.2 - 0.67 9.1 6.9 1.7 7.7 6.9 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 EDK40151.2 - 3.7 7.7 13.1 0.41 10.8 5.5 2.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF2894 PF11445.8 EDK40151.2 - 5.9 7.3 6.8 30 5.0 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) F-box-like PF12937.7 EDK40152.2 - 2.8e-11 43.1 0.0 6.3e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK40152.2 - 8.3e-10 38.3 0.1 2.4e-09 36.8 0.1 1.9 1 0 0 1 1 1 1 F-box domain Mcl1_mid PF12341.8 EDK40152.2 - 0.056 12.8 0.0 0.096 12.0 0.0 1.4 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region CNH PF00780.22 EDK40152.2 - 0.1 12.2 0.6 8.8 5.8 0.2 2.4 2 1 0 2 2 2 0 CNH domain RPM2 PF08579.11 EDK40153.2 - 7.3e-26 90.9 5.0 1.5e-25 89.9 0.9 3.3 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 EDK40153.2 - 0.019 15.1 0.5 7.9 6.8 0.0 4.1 5 0 0 5 5 5 0 PPR repeat family PPR_3 PF13812.6 EDK40153.2 - 0.049 13.7 0.4 23 5.1 0.1 3.5 3 0 0 3 3 3 0 Pentatricopeptide repeat domain Methyltransf_25 PF13649.6 EDK40154.2 - 3.7e-16 59.6 0.0 6.4e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK40154.2 - 4.4e-16 59.3 0.0 7.6e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK40154.2 - 5e-10 39.1 0.0 7.2e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EDK40154.2 - 5.2e-07 30.3 0.0 9.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK40154.2 - 7.2e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK40154.2 - 2.1e-05 24.4 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EDK40154.2 - 0.00022 20.8 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase RrnaAD PF00398.20 EDK40154.2 - 0.00024 20.3 0.0 0.00038 19.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_8 PF05148.15 EDK40154.2 - 0.0024 17.8 0.0 0.0037 17.2 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 EDK40154.2 - 0.064 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DNA_methylase PF00145.17 EDK40154.2 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Mannosyl_trans3 PF11051.8 EDK40155.2 - 8.8e-79 264.7 0.1 3.5e-78 262.7 0.0 1.9 2 0 0 2 2 2 1 Mannosyltransferase putative YchF-GTPase_C PF06071.13 EDK40157.1 - 1.4e-36 124.5 0.0 2.6e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF933) TGS PF02824.21 EDK40157.1 - 0.0078 16.2 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 TGS domain SecA_PP_bind PF01043.20 EDK40157.1 - 0.078 13.6 0.1 0.16 12.7 0.1 1.6 1 0 0 1 1 1 0 SecA preprotein cross-linking domain MMR_HSR1 PF01926.23 EDK40158.1 - 1.9e-16 60.2 0.0 3.4e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK40158.1 - 0.002 17.6 0.0 0.004 16.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDK40158.1 - 0.072 13.2 0.3 2.7 8.0 0.0 2.5 2 1 1 3 3 3 0 Dynamin family AAA_23 PF13476.6 EDK40158.1 - 0.14 12.6 2.4 4.5 7.7 2.4 2.1 1 1 0 1 1 1 0 AAA domain Ribosomal_L37 PF08561.10 EDK40159.1 - 1.7e-20 73.8 7.7 8e-17 61.9 0.8 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 TnpV PF14198.6 EDK40159.1 - 0.039 13.9 0.7 0.056 13.4 0.7 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV Asp PF00026.23 EDK40161.2 - 2.1e-45 155.5 5.3 2.8e-45 155.1 5.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK40161.2 - 1.6e-11 44.7 0.5 1.6e-11 44.7 0.5 2.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal DIL PF01843.19 EDK40162.2 - 1.1e-24 86.7 1.5 7.1e-24 84.1 0.6 2.8 2 1 0 2 2 2 1 DIL domain Ank_2 PF12796.7 EDK40162.2 - 5.5e-11 42.9 0.0 1.7e-06 28.5 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EDK40162.2 - 1.6e-08 34.6 0.0 0.0011 19.3 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EDK40162.2 - 3.7e-08 33.5 0.2 0.001 19.3 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK40162.2 - 3.8e-07 29.9 0.0 0.024 15.1 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EDK40162.2 - 4.1e-05 24.0 0.1 0.51 11.0 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF3276 PF11680.8 EDK40162.2 - 3.5 7.8 8.1 0.32 11.1 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) Man-6-P_recep PF02157.15 EDK40163.2 - 1.4e-11 44.0 0.0 2.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 EDK40163.2 - 8.8e-11 42.1 0.2 1.6e-05 25.0 0.1 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 EDK40163.2 - 0.00027 20.9 0.0 0.00057 19.8 0.0 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 EDK40163.2 - 0.0062 16.2 0.0 0.014 15.1 0.0 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein MTP18 PF10558.9 EDK40164.2 - 9.5e-74 247.0 0.1 1.3e-73 246.5 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF2407_C PF13373.6 EDK40165.2 - 8.7e-38 129.6 0.0 1.3e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EDK40165.2 - 3e-20 72.7 0.1 7e-20 71.5 0.1 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EDK40165.2 - 0.19 11.5 0.0 0.43 10.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family 3-HAO PF06052.12 EDK40166.2 - 1.3e-66 222.9 0.0 1.5e-66 222.7 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EDK40166.2 - 1.9e-06 27.5 0.0 3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EDK40166.2 - 0.023 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_3 PF05899.12 EDK40166.2 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) DUF3658 PF12395.8 EDK40166.2 - 0.19 11.7 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function PaO PF08417.12 EDK40167.2 - 0.049 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Pheophorbide a oxygenase UDPGP PF01704.18 EDK40169.2 - 1.5e-119 399.3 0.0 1.8e-119 399.1 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase IP_trans PF02121.18 EDK40170.2 - 0.032 13.8 0.4 0.56 9.7 0.0 2.6 2 1 1 3 3 3 0 Phosphatidylinositol transfer protein Complex1_49kDa PF00346.19 EDK40171.1 - 4.2e-122 406.5 0.0 5.3e-122 406.1 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EDK40171.1 - 0.012 14.6 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Nickel-dependent hydrogenase DnaJ PF00226.31 EDK40172.2 - 1.1e-17 63.9 2.8 1.1e-17 63.9 2.8 2.1 2 1 1 3 3 3 1 DnaJ domain Trigger_C PF05698.14 EDK40172.2 - 0.061 13.3 0.5 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus DUF2076 PF09849.9 EDK40173.1 - 1.1e-06 28.9 4.9 1.2e-06 28.8 4.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EDK40173.1 - 3.3e-05 23.9 4.0 5.3e-05 23.2 4.0 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EDK40173.1 - 0.011 15.8 3.3 0.016 15.2 3.3 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Trypan_glycop_C PF10659.9 EDK40173.1 - 0.056 13.8 2.1 0.087 13.2 2.1 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain Nucleoporin_FG PF13634.6 EDK40173.1 - 0.27 12.1 6.4 0.51 11.2 6.4 1.6 1 1 0 1 1 1 0 Nucleoporin FG repeat region COX6B PF02297.17 EDK40173.1 - 0.52 10.6 6.5 0.82 10.0 6.5 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Na_K-ATPase PF00287.18 EDK40173.1 - 0.72 9.0 5.7 0.95 8.6 5.7 1.1 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Sec-ASP3 PF15432.6 EDK40175.2 - 0.0034 17.5 0.0 0.0056 16.8 0.0 1.3 1 0 0 1 1 1 1 Accessory Sec secretory system ASP3 Attacin_C PF03769.15 EDK40176.2 - 0.0058 16.9 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Attacin, C-terminal region Insulin_TMD PF17870.1 EDK40176.2 - 0.31 11.1 1.0 0.61 10.2 1.0 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RAP1 PF07218.11 EDK40176.2 - 1 7.6 4.3 1.7 6.9 4.3 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Topoisom_I_N PF02919.15 EDK40177.2 - 4.9e-98 326.9 4.4 4.9e-98 326.9 4.4 2.6 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EDK40177.2 - 2.2e-92 308.5 0.3 2.2e-92 308.5 0.3 2.4 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EDK40177.2 - 2.3e-31 107.5 0.4 8.6e-31 105.7 0.4 2.1 1 0 0 1 1 1 1 C-terminal topoisomerase domain Pkinase PF00069.25 EDK40178.2 - 9.4e-73 244.8 0.0 1.5e-72 244.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40178.2 - 4.2e-38 131.1 0.0 6.4e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EDK40178.2 - 1.4e-23 82.9 0.3 6.8e-13 48.6 0.0 3.0 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EDK40178.2 - 3.6e-10 39.6 0.0 4.3e-09 36.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EDK40178.2 - 0.0026 17.1 0.0 0.0067 15.8 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK40178.2 - 0.053 13.4 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Aminotran_5 PF00266.19 EDK40179.2 - 9.4e-80 268.3 0.0 1.2e-79 268.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDK40179.2 - 1.9e-07 30.7 0.0 2.5e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDK40179.2 - 2.2e-05 23.9 0.1 3.5e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EDK40179.2 - 9.8e-05 21.2 0.1 0.00014 20.7 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain B12-binding PF02310.19 EDK40179.2 - 0.13 12.3 0.1 0.72 9.9 0.0 2.1 2 0 0 2 2 2 0 B12 binding domain Iso_dh PF00180.20 EDK40180.2 - 1.1e-124 416.1 0.0 1.3e-124 415.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3507 PF12015.8 EDK40181.2 - 4.7e-43 147.0 0.1 2.2e-42 144.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3507) DUF3130 PF11328.8 EDK40181.2 - 0.00093 19.4 0.2 0.081 13.2 0.2 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3130 YlbE PF14003.6 EDK40181.2 - 0.034 14.6 0.3 0.093 13.2 0.3 1.7 1 0 0 1 1 1 0 YlbE-like protein NOT2_3_5 PF04153.18 EDK40181.2 - 0.04 14.0 0.1 0.13 12.3 0.1 1.9 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family HapK PF11639.8 EDK40181.2 - 0.076 13.5 0.0 0.28 11.7 0.0 2.0 1 0 0 1 1 1 0 REDY-like protein HapK DUF2015 PF09435.10 EDK40182.2 - 1.5e-39 134.3 0.2 1.9e-39 134.0 0.2 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF3673 PF12425.8 EDK40182.2 - 0.089 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) RRM_1 PF00076.22 EDK40183.2 - 2.7e-42 142.4 0.5 1.7e-18 66.2 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDK40183.2 - 3.2e-06 27.1 0.8 2 8.5 0.0 3.6 3 2 0 3 3 3 3 Limkain b1 RRM_5 PF13893.6 EDK40183.2 - 1.8e-05 24.3 0.0 0.00024 20.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EDK40183.2 - 0.0037 17.1 0.0 0.13 12.1 0.1 2.2 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EDK40183.2 - 0.0038 17.0 0.0 1 9.2 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif DUF1325 PF07039.11 EDK40184.2 - 1.1e-34 119.3 0.0 1.9e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EDK40184.2 - 4.7e-05 23.1 0.0 9.3e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EDK40184.2 - 0.021 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) PilZ PF07238.14 EDK40184.2 - 0.025 14.9 0.0 0.34 11.3 0.0 2.2 2 0 0 2 2 2 0 PilZ domain Agenet PF05641.12 EDK40184.2 - 0.035 14.6 0.1 2.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Agenet domain ER_lumen_recept PF00810.18 EDK40185.2 - 2e-06 28.7 8.3 2.9e-05 24.9 8.1 2.2 1 1 1 2 2 2 2 ER lumen protein retaining receptor PQ-loop PF04193.14 EDK40185.2 - 0.00043 20.0 7.8 0.0025 17.6 0.2 2.7 2 0 0 2 2 2 2 PQ loop repeat PLDc_2 PF13091.6 EDK40186.2 - 3.3e-14 52.9 0.0 5.2e-07 29.6 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDK40186.2 - 5.5e-07 29.5 2.2 0.013 15.6 0.1 3.7 3 1 0 3 3 3 2 Phospholipase D Active site motif YchF-GTPase_C PF06071.13 EDK40187.2 - 5e-30 103.5 0.0 2.2e-29 101.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDK40187.2 - 1e-16 61.0 0.1 5.7e-16 58.6 0.0 2.3 2 1 1 3 3 3 1 50S ribosome-binding GTPase TGS PF02824.21 EDK40187.2 - 2e-06 27.7 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDK40187.2 - 0.00054 19.5 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B COG5 PF10392.9 EDK40187.2 - 0.0064 16.7 1.5 0.048 13.8 0.2 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 AAA_14 PF13173.6 EDK40187.2 - 0.0084 16.1 0.0 0.048 13.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain MFS_1 PF07690.16 EDK40188.2 - 7.3e-36 123.8 37.5 7.3e-36 123.8 37.5 2.1 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK40188.2 - 4.3e-15 55.5 7.8 4.3e-15 55.5 7.8 2.4 2 1 0 3 3 3 1 Sugar (and other) transporter Ribosomal_L27_C PF18471.1 EDK40189.1 - 2.2e-34 119.0 14.8 2.8e-34 118.6 14.8 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 EDK40189.1 - 1.2e-32 111.8 0.2 2.1e-32 110.9 0.2 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein GvpL_GvpF PF06386.11 EDK40189.1 - 0.0081 16.1 4.3 0.0081 16.1 4.3 1.8 2 0 0 2 2 2 1 Gas vesicle synthesis protein GvpL/GvpF Stork_head PF10264.9 EDK40189.1 - 0.1 12.8 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain Tau95 PF09734.9 EDK40189.1 - 0.12 13.2 4.3 0.16 12.8 0.1 2.2 1 1 1 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Rer1 PF03248.13 EDK40190.2 - 3.5e-80 267.7 7.0 4e-80 267.6 7.0 1.0 1 0 0 1 1 1 1 Rer1 family DUF1538 PF07556.11 EDK40190.2 - 0.65 9.2 4.7 1.5 8.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1538) ANTH PF07651.16 EDK40191.2 - 3.1e-78 262.6 0.0 3.1e-78 262.6 0.0 4.3 3 1 1 4 4 4 1 ANTH domain I_LWEQ PF01608.17 EDK40191.2 - 7.3e-53 178.9 6.3 7.3e-53 178.9 6.3 7.0 3 2 1 5 5 5 1 I/LWEQ domain Collagen_mid PF15984.5 EDK40191.2 - 0.022 14.5 2.8 0.062 13.1 2.8 1.8 1 0 0 1 1 1 0 Bacterial collagen, middle region PSII_Pbs27 PF13326.6 EDK40191.2 - 1.8 8.9 9.4 0.19 12.1 1.1 2.9 3 0 0 3 3 3 0 Photosystem II Pbs27 AA_permease PF00324.21 EDK40192.2 - 5.5e-79 266.0 16.9 6.1e-79 265.8 16.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40192.2 - 1.1e-26 93.7 20.3 1.5e-26 93.2 20.3 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK40193.2 - 6.1e-28 97.6 17.2 6.8e-28 97.5 17.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40193.2 - 1.1e-07 31.1 15.4 1.2e-07 31.0 15.4 1.0 1 0 0 1 1 1 1 Amino acid permease adh_short PF00106.25 EDK40194.2 - 1e-07 31.6 0.5 3.5e-07 29.9 0.5 1.8 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_7 PF13241.6 EDK40194.2 - 0.00017 21.9 0.0 0.00029 21.2 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_10 PF13460.6 EDK40194.2 - 0.00067 19.6 0.0 0.00095 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EDK40194.2 - 0.00088 19.2 0.1 0.0014 18.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK40194.2 - 0.0012 18.3 0.1 0.002 17.6 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EDK40194.2 - 0.0017 17.7 0.0 0.0034 16.7 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.24 EDK40194.2 - 0.0097 16.3 0.0 0.028 14.8 0.1 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EDK40194.2 - 0.01 15.4 0.6 0.015 14.8 0.6 1.4 1 1 0 1 1 1 1 NmrA-like family 3HCDH_N PF02737.18 EDK40194.2 - 0.013 15.4 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EDK40194.2 - 0.02 14.5 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 EDK40194.2 - 0.03 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDK40194.2 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EDK40194.2 - 0.15 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 ThiF family UEV PF05743.13 EDK40195.2 - 2.4e-24 85.5 0.0 4.9e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EDK40195.2 - 6.4e-11 42.0 0.0 1.5e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Vps23 core domain Acetyltransf_4 PF13420.7 EDK40195.2 - 0.012 15.7 0.2 0.06 13.5 0.1 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Flagellin_C PF00700.21 EDK40195.2 - 0.25 11.7 1.4 0.29 11.5 0.4 1.6 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region DKCLD PF08068.12 EDK40196.2 - 4.1e-32 110.0 0.2 4.5e-31 106.7 0.3 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EDK40196.2 - 3.1e-22 78.5 0.5 6.2e-22 77.5 0.5 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EDK40196.2 - 2e-20 72.5 0.6 4.1e-20 71.5 0.6 1.6 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 EDK40196.2 - 2.7e-20 73.2 5.6 6.3e-19 68.8 0.0 3.6 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 EDK40196.2 - 0.0042 17.3 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain GAGA_bind PF06217.12 EDK40196.2 - 1.5 9.1 15.4 2.1 8.6 15.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family EOS1 PF12326.8 EDK40196.2 - 3.7 7.5 5.7 7.2 6.5 5.7 1.4 1 0 0 1 1 1 0 N-glycosylation protein Cohesin_load PF10345.9 EDK40197.2 - 1.7e-47 162.2 16.5 2e-47 162.0 16.5 1.0 1 0 0 1 1 1 1 Cohesin loading factor IL6 PF00489.17 EDK40198.2 - 0.023 14.3 0.4 0.55 9.8 0.6 2.7 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family NPV_P10 PF05531.12 EDK40198.2 - 2 8.9 6.6 2.3 8.7 0.2 3.4 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Exo_endo_phos PF03372.23 EDK40199.2 - 3.9e-12 46.2 0.0 6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EDK40199.2 - 4e-11 42.8 2.6 8.1e-11 41.8 2.6 1.6 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 EDK40199.2 - 8.3e-06 25.6 0.0 0.18 11.6 0.0 2.8 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase TBP PF00352.21 EDK40200.1 - 1.7e-67 223.4 0.1 8.1e-33 112.2 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDK40200.1 - 0.00031 20.8 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EDK40200.1 - 0.1 12.4 0.1 0.62 9.9 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DUF4116 PF13475.6 EDK40201.2 - 0.048 13.4 0.2 0.4 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) BAR PF03114.18 EDK40202.1 - 4.8e-55 186.8 1.1 5.5e-55 186.6 1.1 1.0 1 0 0 1 1 1 1 BAR domain DUF2303 PF10065.9 EDK40202.1 - 0.039 13.1 0.1 0.056 12.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) HAUS-augmin3 PF14932.6 EDK40202.1 - 0.052 13.1 0.2 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 PRD PF00874.20 EDK40202.1 - 0.065 13.5 0.1 0.25 11.7 0.1 2.0 2 0 0 2 2 2 0 PRD domain DUF4164 PF13747.6 EDK40202.1 - 0.086 13.1 0.7 1.8 8.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Actin PF00022.19 EDK40204.2 - 1.2e-11 43.9 0.0 1.2e-05 24.1 0.0 2.8 1 1 1 2 2 2 2 Actin zf-RING_9 PF13901.6 EDK40204.2 - 0.0078 16.2 0.5 0.013 15.5 0.5 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon DEAD_2 PF06733.15 EDK40205.2 - 5.2e-56 189.0 1.6 5.2e-56 189.0 1.6 1.7 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 EDK40205.2 - 7.7e-49 166.0 2.0 1.3e-44 152.1 0.5 2.7 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EDK40205.2 - 4.4e-43 147.4 0.0 1.3e-42 145.9 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 EDK40205.2 - 0.00028 20.9 0.4 0.006 16.6 0.1 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK40205.2 - 0.0022 17.8 0.0 0.62 9.8 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase YtxC PF08812.11 EDK40205.2 - 0.14 11.7 3.4 0.3 10.7 0.1 2.9 4 0 0 4 4 4 0 YtxC-like family ADK PF00406.22 EDK40206.2 - 9.8e-43 145.8 0.0 1.3e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDK40206.2 - 1.6e-19 70.7 0.0 2.5e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDK40206.2 - 1.3e-13 50.7 0.0 2.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDK40206.2 - 6.4e-06 26.7 0.0 1.1e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK40206.2 - 0.0077 16.4 0.5 0.024 14.8 0.2 1.9 2 1 0 2 2 2 1 AAA domain Leo1 PF04004.13 EDK40207.2 - 1.2e-43 148.8 1.5 1.2e-43 148.8 1.5 2.3 2 0 0 2 2 2 1 Leo1-like protein RhoGAP PF00620.27 EDK40208.2 - 5.1e-36 123.8 0.5 5.3e-20 71.8 0.0 2.7 3 0 0 3 3 3 2 RhoGAP domain baeRF_family5 PF18846.1 EDK40208.2 - 0.14 12.4 0.1 0.14 12.4 0.1 1.7 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Mito_fiss_reg PF05308.11 EDK40208.2 - 2 8.5 8.6 0.26 11.3 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator BAR PF03114.18 EDK40209.2 - 1.4e-60 204.9 8.0 1.8e-60 204.6 8.0 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EDK40209.2 - 3.7e-15 55.2 0.4 6.5e-15 54.5 0.0 1.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDK40209.2 - 5.1e-14 51.9 0.2 8.6e-14 51.1 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK40209.2 - 1.8e-09 37.1 0.0 4e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF2151 PF10221.9 EDK40209.2 - 0.026 13.2 1.8 0.033 12.8 1.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator peroxidase PF00141.23 EDK40210.2 - 2.3e-46 158.3 0.0 3.6e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Peroxidase IDO PF01231.18 EDK40211.2 - 6.8e-150 499.6 0.0 7.8e-150 499.4 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Clathrin_propel PF01394.20 EDK40211.2 - 0.16 12.3 0.1 0.38 11.2 0.1 1.6 1 0 0 1 1 1 0 Clathrin propeller repeat tRNA-synt_His PF13393.6 EDK40212.2 - 8.3e-40 137.0 0.1 6.4e-33 114.3 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EDK40212.2 - 4.9e-13 49.0 0.7 1.1e-12 48.0 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDK40212.2 - 0.0015 18.5 0.0 0.017 15.1 0.0 2.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 EDK40212.2 - 0.0015 17.7 0.0 0.014 14.5 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) HGTP_anticodon2 PF12745.7 EDK40212.2 - 0.0016 18.0 0.2 0.0016 18.0 0.2 2.5 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Ribosomal_60s PF00428.19 EDK40212.2 - 0.0041 17.7 5.0 2.3 8.9 0.1 3.1 2 0 0 2 2 2 2 60s Acidic ribosomal protein FA_desaturase PF00487.24 EDK40213.2 - 7.1e-24 85.0 11.1 7.1e-24 85.0 11.1 1.8 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 EDK40213.2 - 1.2e-16 59.9 0.3 2.7e-16 58.7 0.3 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) EST1_DNA_bind PF10373.9 EDK40214.2 - 3.6e-45 154.6 6.6 3.6e-45 154.6 6.6 2.3 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EDK40214.2 - 3.5e-17 63.3 1.7 3.5e-17 63.3 1.7 2.5 2 0 0 2 2 2 1 Telomerase activating protein Est1 Peptidase_C97 PF05903.14 EDK40215.1 - 8.7e-39 132.8 0.0 9.6e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EDK40215.1 - 0.044 14.1 0.8 0.17 12.2 0.8 1.6 1 1 1 2 2 2 0 Lecithin retinol acyltransferase Wtap PF17098.5 EDK40216.2 - 1e-07 32.0 5.4 2.1e-07 31.0 5.4 1.5 1 0 0 1 1 1 1 WTAP/Mum2p family DUF3496 PF12001.8 EDK40216.2 - 0.088 13.2 0.1 0.088 13.2 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) Myc-LZ PF02344.15 EDK40216.2 - 0.11 12.7 4.0 0.24 11.6 0.1 3.1 3 0 0 3 3 3 0 Myc leucine zipper domain BRX_N PF13713.6 EDK40216.2 - 0.16 11.7 1.3 0.44 10.4 1.3 1.7 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain CENP-H PF05837.12 EDK40216.2 - 0.29 11.6 5.3 0.12 12.8 2.8 1.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF1640 PF07798.11 EDK40216.2 - 0.71 9.9 8.6 2.5 8.1 8.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) HALZ PF02183.18 EDK40216.2 - 0.8 10.0 5.6 15 5.9 0.1 3.9 4 1 0 4 4 4 0 Homeobox associated leucine zipper Cdh1_DBD_1 PF18196.1 EDK40216.2 - 6.3 7.1 6.9 5.4 7.4 2.9 2.2 1 1 1 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Actin PF00022.19 EDK40217.2 - 3.2e-72 243.4 0.0 7.5e-72 242.2 0.0 1.6 1 1 0 1 1 1 1 Actin ECH_2 PF16113.5 EDK40218.2 - 1.9e-109 366.2 0.0 2.5e-109 365.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EDK40218.2 - 2.3e-24 86.1 0.1 4.1e-22 78.7 0.0 2.9 1 1 2 3 3 3 1 Enoyl-CoA hydratase/isomerase Pec_lyase_N PF04431.13 EDK40218.2 - 0.062 13.5 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Pectate lyase, N terminus WD40 PF00400.32 EDK40219.2 - 5.1e-07 30.3 1.6 0.0034 18.2 0.1 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40219.2 - 1.7e-05 25.0 0.0 0.0025 18.1 0.0 3.7 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK40219.2 - 0.00095 18.2 0.3 0.16 10.9 0.0 2.5 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EDK40219.2 - 0.014 14.6 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Gmad1 PF10647.9 EDK40219.2 - 0.032 14.0 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Sec62 PF03839.16 EDK40220.2 - 1.6e-72 243.5 3.3 2.2e-72 243.1 3.3 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 Arrestin_C PF02752.22 EDK40221.2 - 1e-23 84.3 0.0 3e-22 79.5 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDK40221.2 - 3.8e-06 27.0 0.0 6.5e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Abhydrolase_1 PF00561.20 EDK40222.2 - 3.4e-13 49.8 0.0 5e-12 46.0 0.0 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK40222.2 - 2.2e-06 28.5 0.0 3.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK40222.2 - 2.4e-06 27.0 0.0 1.3e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EDK40222.2 - 0.059 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Glyco_transf_20 PF00982.21 EDK40223.2 - 1.7e-150 501.8 0.0 2.2e-150 501.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDK40223.2 - 1.6e-74 250.0 0.0 3.1e-74 249.0 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase LYTB PF02401.18 EDK40223.2 - 0.0097 15.2 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 1 LytB protein Glycos_transf_1 PF00534.20 EDK40223.2 - 0.021 14.3 0.0 0.082 12.4 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferases group 1 Hydrolase_3 PF08282.12 EDK40223.2 - 0.046 13.5 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 EDK40224.2 - 5.4e-87 285.6 2.8 1.6e-21 75.9 0.3 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EDK40224.2 - 1.9e-19 69.6 0.2 1.9e-19 69.6 0.2 2.7 4 0 0 4 4 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EDK40224.2 - 1.1e-05 25.0 0.0 0.088 12.4 0.0 3.6 1 1 3 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK40224.2 - 3.3e-05 23.7 0.0 0.011 15.6 0.0 2.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EDK40224.2 - 0.00019 21.5 0.2 8 6.7 0.0 4.7 4 1 0 4 4 4 1 RNA recognition motif YflT PF11181.8 EDK40224.2 - 0.00021 21.8 0.3 0.44 11.1 0.2 2.8 2 0 0 2 2 2 2 Heat induced stress protein YflT DUF4523 PF15023.6 EDK40224.2 - 0.0012 18.7 0.0 1.9 8.3 0.0 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF4523) Calcipressin PF04847.12 EDK40224.2 - 0.0016 18.2 2.8 1 9.1 0.2 3.6 4 0 0 4 4 4 1 Calcipressin Limkain-b1 PF11608.8 EDK40224.2 - 0.0084 16.2 0.4 0.97 9.6 0.1 3.2 2 0 0 2 2 2 1 Limkain b1 Nup35_RRM_2 PF14605.6 EDK40224.2 - 0.0087 16.0 0.2 15 5.7 0.0 3.5 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 EDK40224.2 - 0.027 14.6 0.0 18 5.5 0.0 3.2 3 0 0 3 3 3 0 Cobalamin biosynthesis central region Nefa_Nip30_N PF10187.9 EDK40224.2 - 0.03 14.7 0.6 0.03 14.7 0.6 2.8 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF4078 PF13300.6 EDK40224.2 - 0.086 13.2 6.4 0.2 12.0 0.5 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4078) SNF2_N PF00176.23 EDK40225.2 - 4.1e-60 203.3 0.0 7.1e-60 202.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cdh1_DBD_1 PF18196.1 EDK40225.2 - 1.1e-33 116.1 2.6 1.1e-33 116.1 2.6 4.4 4 0 0 4 4 4 1 Chromodomain helicase DNA-binding domain 1 DUF4208 PF13907.6 EDK40225.2 - 5.1e-26 90.9 1.1 5.1e-26 90.9 1.1 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Chromo PF00385.24 EDK40225.2 - 4.1e-22 77.8 8.0 4.9e-13 48.8 2.0 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EDK40225.2 - 1.1e-19 70.8 0.0 3.3e-19 69.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK40225.2 - 1.1e-08 35.3 2.2 3e-08 33.8 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EDK40225.2 - 0.069 13.3 0.0 0.069 13.3 0.0 3.0 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain YdfA_immunity PF12127.8 EDK40225.2 - 0.57 9.2 2.1 1.1 8.3 2.1 1.3 1 0 0 1 1 1 0 SigmaW regulon antibacterial ABC_tran PF00005.27 EDK40226.2 - 1.1e-33 116.7 0.0 1.3e-15 58.2 0.0 2.5 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 EDK40226.2 - 2.9e-13 49.4 5.1 6.9e-13 48.2 5.1 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EDK40226.2 - 7.8e-10 38.6 0.7 0.021 14.3 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDK40226.2 - 1.1e-08 35.2 5.8 0.21 11.3 1.1 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 EDK40226.2 - 5.8e-08 32.2 3.3 5.8e-08 32.2 3.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA PF00004.29 EDK40226.2 - 1.3e-05 25.6 0.0 0.048 14.1 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) Fer4_6 PF12837.7 EDK40226.2 - 4.3e-05 23.4 2.7 4.3e-05 23.4 2.7 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 EDK40226.2 - 8.9e-05 22.5 0.0 0.47 10.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EDK40226.2 - 0.00017 21.5 0.4 0.31 10.7 0.0 3.1 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EDK40226.2 - 0.00027 21.2 0.0 0.083 13.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK40226.2 - 0.00047 20.6 0.0 0.45 10.9 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EDK40226.2 - 0.00049 19.8 0.2 0.54 10.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Fer4_21 PF14697.6 EDK40226.2 - 0.00078 19.5 12.0 0.0018 18.4 12.0 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDK40226.2 - 0.0012 19.4 0.3 0.0012 19.4 0.3 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDK40226.2 - 0.0025 17.9 1.5 0.0025 17.9 1.5 2.4 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EDK40226.2 - 0.0025 17.8 0.9 0.0025 17.8 0.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_24 PF13479.6 EDK40226.2 - 0.0027 17.5 0.3 0.71 9.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 EDK40226.2 - 0.0029 17.7 11.2 0.0062 16.7 11.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Rad17 PF03215.15 EDK40226.2 - 0.003 17.5 0.1 0.68 9.8 0.1 2.6 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_13 PF13166.6 EDK40226.2 - 0.0032 16.2 0.2 0.0075 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDK40226.2 - 0.0034 17.9 0.0 5.5 7.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDK40226.2 - 0.0041 17.7 0.0 0.6 10.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDK40226.2 - 0.0043 17.0 0.7 1 9.2 0.0 2.6 3 0 0 3 3 2 1 NACHT domain AAA_33 PF13671.6 EDK40226.2 - 0.0051 17.0 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EDK40226.2 - 0.0051 17.2 0.1 1.3 9.5 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Fer4_16 PF13484.6 EDK40226.2 - 0.0052 17.7 0.2 0.0052 17.7 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain SRP54 PF00448.22 EDK40226.2 - 0.0082 15.8 1.8 0.68 9.5 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NB-ARC PF00931.22 EDK40226.2 - 0.012 14.8 0.0 0.62 9.2 0.0 2.4 2 1 1 3 3 3 0 NB-ARC domain AAA_30 PF13604.6 EDK40226.2 - 0.02 14.6 0.4 2 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDK40226.2 - 0.033 14.2 0.2 0.4 10.7 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EDK40226.2 - 0.036 14.3 0.8 11 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EDK40226.2 - 0.036 14.1 0.1 11 6.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.6 EDK40226.2 - 0.042 13.4 0.4 0.54 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDK40226.2 - 0.073 13.1 1.0 0.68 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) VirE PF05272.11 EDK40226.2 - 0.093 12.5 0.0 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E Fer4_8 PF13183.6 EDK40226.2 - 0.11 13.0 6.0 0.13 12.7 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain SbcCD_C PF13558.6 EDK40226.2 - 0.15 12.3 0.0 12 6.2 0.0 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 EDK40226.2 - 0.16 12.0 0.2 27 4.9 0.1 2.8 3 0 0 3 3 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 EDK40226.2 - 0.19 11.4 0.5 22 4.6 0.1 2.9 3 0 0 3 3 3 0 Thymidylate kinase Fer4_4 PF12800.7 EDK40226.2 - 0.58 10.8 14.8 0.26 11.9 2.8 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 EDK40226.2 - 1.4 9.5 10.0 0.077 13.6 0.9 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EDK40226.2 - 4.1 8.6 15.7 0.16 13.0 3.5 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Peptidase_M24 PF00557.24 EDK40227.1 - 0.00045 20.0 0.0 0.0007 19.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AAA PF00004.29 EDK40227.1 - 0.12 12.7 0.0 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) 14-3-3 PF00244.20 EDK40228.1 - 8.3e-104 345.9 4.9 9.5e-104 345.7 4.9 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 EDK40228.1 - 0.053 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Flagellar protein FlaF Septin PF00735.18 EDK40229.2 - 6.5e-112 373.4 0.0 1.1e-111 372.6 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDK40229.2 - 2.4e-08 34.0 0.0 4.9e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK40229.2 - 1.7e-05 24.5 0.1 0.0014 18.2 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDK40229.2 - 7.2e-05 22.7 4.5 0.00093 19.1 0.5 3.6 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EDK40229.2 - 0.0016 18.8 0.0 0.005 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 EDK40229.2 - 0.002 18.3 0.0 0.0068 16.6 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EDK40229.2 - 0.0036 17.6 0.0 0.0093 16.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF5082 PF16888.5 EDK40229.2 - 0.0037 17.5 0.7 0.0076 16.5 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) KAP_NTPase PF07693.14 EDK40229.2 - 0.0083 15.4 0.3 0.056 12.7 0.0 2.1 1 1 1 2 2 2 1 KAP family P-loop domain AIG1 PF04548.16 EDK40229.2 - 0.011 15.0 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Ras PF00071.22 EDK40229.2 - 0.025 14.2 0.1 0.13 11.8 0.1 2.1 1 1 0 1 1 1 0 Ras family AAA_7 PF12775.7 EDK40229.2 - 0.032 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EDK40229.2 - 0.035 14.6 0.1 0.11 13.0 0.0 1.9 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 EDK40229.2 - 0.067 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EDK40229.2 - 0.071 12.8 0.3 0.16 11.7 0.3 1.7 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK40229.2 - 0.074 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EDK40229.2 - 0.15 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Dynamin_N PF00350.23 EDK40229.2 - 0.24 11.4 6.5 10 6.1 0.0 3.2 2 1 1 3 3 3 0 Dynamin family Zn_clus PF00172.18 EDK40230.2 - 1e-07 31.9 8.3 1.7e-07 31.2 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK40230.2 - 0.0001 21.4 7.7 0.00039 19.5 3.0 3.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain UPF0506 PF11703.8 EDK40230.2 - 0.35 11.3 3.4 0.68 10.3 3.4 1.4 1 0 0 1 1 1 0 UPF0506 Fungal_trans PF04082.18 EDK40231.2 - 2.1e-17 63.0 0.2 3.6e-17 62.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40231.2 - 2.4e-09 37.2 10.6 3.9e-09 36.5 10.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin PF00261.20 EDK40231.2 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Tropomyosin SUN PF03856.13 EDK40232.2 - 1.6e-83 280.0 15.7 1.8e-83 279.8 15.7 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Fer4_10 PF13237.6 EDK40232.2 - 0.028 14.5 0.1 0.089 12.9 0.1 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain DUF4658 PF15555.6 EDK40233.2 - 0.024 14.7 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) DUF2304 PF10066.9 EDK40233.2 - 0.73 10.1 7.1 1.2 9.4 7.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Myb_DNA-bind_6 PF13921.6 EDK40234.2 - 3.2e-09 36.9 1.0 1.3e-08 35.0 1.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain HSA PF07529.13 EDK40234.2 - 2.4e-08 34.2 0.0 2.4e-08 34.2 0.0 3.1 3 0 0 3 3 3 1 HSA Myb_DNA-binding PF00249.31 EDK40234.2 - 0.0042 17.3 0.2 0.011 15.9 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZapA PF05164.13 EDK40234.2 - 4.9 7.7 8.8 0.6 10.6 3.3 2.4 2 0 0 2 2 2 0 Cell division protein ZapA PH_4 PF15404.6 EDK40235.2 - 1.4e-61 207.5 0.5 9.7e-61 204.8 0.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EDK40235.2 - 1.2e-22 79.3 0.3 7e-22 76.8 0.3 2.5 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 EDK40235.2 - 3.7e-09 37.0 2.5 0.37 11.3 0.1 5.4 4 2 0 4 4 4 3 PH domain PH_6 PF15406.6 EDK40235.2 - 0.0047 17.2 0.0 2.7 8.3 0.0 3.4 4 0 0 4 4 4 1 Pleckstrin homology domain PH_13 PF16652.5 EDK40235.2 - 0.025 14.4 0.1 2 8.2 0.1 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain PH_12 PF16457.5 EDK40235.2 - 0.13 12.8 1.1 0.56 10.7 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain TMEM234 PF10639.9 EDK40235.2 - 0.16 12.0 0.0 0.91 9.6 0.0 2.1 2 0 0 2 2 2 0 Putative transmembrane family 234 zf-RING_2 PF13639.6 EDK40236.2 - 0.022 15.1 1.8 0.022 15.1 1.8 2.2 2 1 1 3 3 3 0 Ring finger domain E1_dh PF00676.20 EDK40237.2 - 2.6e-120 400.9 0.1 3.1e-120 400.7 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDK40237.2 - 0.0042 16.3 0.0 0.0067 15.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Sec63 PF02889.16 EDK40238.2 - 3.5e-79 265.6 0.2 6e-79 264.8 0.2 1.4 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EDK40238.2 - 7.7e-34 117.0 0.0 1.2e-25 90.3 0.0 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EDK40238.2 - 2e-26 92.3 1.0 2e-26 92.3 1.0 2.9 3 0 0 3 3 3 1 N-terminal helicase PWI domain ResIII PF04851.15 EDK40238.2 - 5e-18 65.7 0.0 1.9e-16 60.6 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDK40238.2 - 2.9e-10 40.5 0.5 5.1e-09 36.5 0.0 3.2 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDK40238.2 - 0.0028 17.9 0.0 0.015 15.5 0.0 2.3 1 0 0 1 1 1 1 AAA domain DUF4611 PF15387.6 EDK40239.2 - 0.14 12.3 0.6 0.26 11.5 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Glycos_transf_3 PF00591.21 EDK40240.1 - 4.9e-64 216.4 0.0 5.5e-64 216.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Cnn_1N PF07989.11 EDK40241.2 - 6.6e-08 32.6 6.5 6.6e-08 32.6 6.5 14.1 4 1 7 12 12 9 3 Centrosomin N-terminal motif 1 MAD PF05557.13 EDK40241.2 - 0.0011 17.5 1.9 0.0011 17.5 1.9 6.8 1 1 4 5 5 4 3 Mitotic checkpoint protein DUF724 PF05266.14 EDK40241.2 - 0.0018 18.1 5.3 0.0018 18.1 5.3 9.4 2 2 6 9 9 8 2 Protein of unknown function (DUF724) UPF0242 PF06785.11 EDK40241.2 - 0.0043 17.2 13.0 0.0043 17.2 13.0 9.9 2 1 6 8 8 7 2 Uncharacterised protein family (UPF0242) N-terminus SOGA PF11365.8 EDK40241.2 - 0.0043 18.1 5.9 0.0043 18.1 5.9 12.0 6 5 7 13 13 12 2 Protein SOGA CENP-F_leu_zip PF10473.9 EDK40241.2 - 0.0045 17.0 16.5 0.0045 17.0 16.5 10.2 3 2 8 11 11 10 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 EDK40241.2 - 0.0071 16.6 23.5 0.0071 16.6 23.5 9.5 2 1 7 9 9 8 3 Autophagy protein 16 (ATG16) Prefoldin PF02996.17 EDK40241.2 - 0.0087 16.0 1.5 0.0087 16.0 1.5 14.5 11 4 3 16 16 16 1 Prefoldin subunit Laminin_II PF06009.12 EDK40241.2 - 0.009 16.0 9.3 0.009 16.0 9.3 9.1 4 2 5 10 10 10 2 Laminin Domain II Spc110_C PF18520.1 EDK40241.2 - 0.024 14.2 0.7 0.024 14.2 0.7 4.1 4 0 0 4 4 4 0 Spindle pole body component 110 C-terminal domain MtrB PF05440.12 EDK40241.2 - 0.038 14.4 1.6 0.87 10.0 0.1 4.2 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF3072 PF11272.8 EDK40241.2 - 0.038 13.9 3.0 0.25 11.2 0.3 3.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) Apc13p PF05839.11 EDK40242.2 - 5.9e-06 26.4 0.8 1.6e-05 25.0 0.8 1.7 1 1 0 1 1 1 1 Apc13p protein Roughex PF06020.11 EDK40243.2 - 0.92 8.5 4.1 0.2 10.7 0.8 1.5 2 0 0 2 2 2 0 Drosophila roughex protein HEXIM PF15313.6 EDK40243.2 - 3.3 7.9 10.7 6.5 6.9 0.3 2.3 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein BUD22 PF09073.10 EDK40243.2 - 6.3 6.0 14.5 0.73 9.1 5.4 2.0 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 EDK40243.2 - 6.9 4.7 6.9 1.1 7.4 2.8 1.6 2 0 0 2 2 2 0 Nop14-like family CCDC24 PF15669.5 EDK40243.2 - 7.5 6.4 7.7 4 7.3 0.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Zip PF02535.22 EDK40244.2 - 8.7e-13 48.2 4.2 8.7e-13 48.2 4.2 1.9 2 1 0 2 2 2 1 ZIP Zinc transporter Thyroglobulin_1 PF00086.18 EDK40244.2 - 0.16 11.7 4.8 2.7 7.7 0.1 3.6 3 1 0 3 3 3 0 Thyroglobulin type-1 repeat RNA_pol_Rpb1_5 PF04998.17 EDK40245.2 - 8.7e-84 281.1 0.1 1.5e-83 280.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDK40245.2 - 1.7e-75 252.8 0.2 6.5e-75 250.9 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EDK40245.2 - 2e-60 204.8 0.0 3.4e-60 204.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EDK40245.2 - 1.7e-38 132.1 0.0 7e-38 130.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDK40245.2 - 5e-31 106.8 0.1 1.9e-30 105.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 DSS1_SEM1 PF05160.13 EDK40246.1 - 1.2e-21 76.5 19.2 1.4e-21 76.3 19.2 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family Nuc_deoxyri_tr2 PF15891.5 EDK40246.1 - 0.19 12.0 8.2 0.43 10.9 1.0 2.0 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like AAA PF00004.29 EDK40247.2 - 7.8e-41 139.6 0.0 1.4e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDK40247.2 - 1e-17 63.8 0.2 2.5e-17 62.6 0.2 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDK40247.2 - 5.2e-08 32.6 0.0 1.3e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDK40247.2 - 1.3e-05 25.6 0.3 0.019 15.4 0.0 2.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 EDK40247.2 - 7.8e-05 22.9 0.0 0.00026 21.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDK40247.2 - 0.00077 19.2 0.1 0.002 17.9 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDK40247.2 - 0.00081 19.4 0.2 0.0066 16.5 0.2 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK40247.2 - 0.0031 17.8 2.1 0.16 12.3 0.0 3.1 3 1 1 4 4 4 1 AAA domain AAA_33 PF13671.6 EDK40247.2 - 0.0041 17.3 0.0 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDK40247.2 - 0.02 14.0 0.0 0.046 12.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 EDK40247.2 - 0.021 14.3 0.1 0.07 12.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 EDK40247.2 - 0.023 14.1 0.2 0.058 12.8 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDK40247.2 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Cdh1_DBD_1 PF18196.1 EDK40247.2 - 0.11 12.9 2.4 1.1 9.6 0.0 2.6 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 AAA_24 PF13479.6 EDK40247.2 - 0.16 11.7 0.7 0.56 9.9 0.1 2.3 2 1 0 2 2 2 0 AAA domain JIP_LZII PF16471.5 EDK40247.2 - 1.3 9.3 9.5 0.11 12.7 3.6 2.4 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II TolA_bind_tri PF16331.5 EDK40247.2 - 5.5 7.1 6.4 8.5 6.5 4.1 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Glyco_hydro_1 PF00232.18 EDK40248.2 - 5.3e-75 252.6 2.6 7.9e-74 248.7 2.6 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 Peptidase_M24 PF00557.24 EDK40249.1 - 2.2e-48 164.7 0.0 2.7e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EDK40249.1 - 1.3e-18 67.0 5.6 3.1e-18 65.8 5.6 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EDK40249.1 - 0.0026 17.8 3.7 0.0026 17.8 3.7 2.0 2 0 0 2 2 2 1 MYND finger Translin PF01997.16 EDK40250.2 - 1.2e-45 156.1 0.2 1.4e-45 155.8 0.2 1.1 1 0 0 1 1 1 1 Translin family Nucleolin_bd PF16725.5 EDK40250.2 - 0.16 11.6 0.5 0.4 10.4 0.0 1.8 2 0 0 2 2 2 0 Nucleolin binding domain Cpn60_TCP1 PF00118.24 EDK40251.2 - 1e-159 532.3 1.1 1.2e-159 532.1 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Zn_clus PF00172.18 EDK40252.2 - 9.9e-06 25.6 11.9 1.8e-05 24.7 11.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.9 EDK40252.2 - 0.0086 15.7 5.0 0.018 14.7 5.0 1.6 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Sec1 PF00995.23 EDK40254.2 - 1.1e-115 388.2 5.8 1.2e-115 388.0 5.8 1.0 1 0 0 1 1 1 1 Sec1 family TIP49 PF06068.13 EDK40255.2 - 1.2e-167 557.5 0.2 1.5e-167 557.2 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDK40255.2 - 1.2e-19 70.2 0.0 3.1e-19 68.9 0.0 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain RuvB_N PF05496.12 EDK40255.2 - 1.1e-10 41.4 0.2 3.2e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EDK40255.2 - 3.2e-10 40.5 0.3 1.6e-06 28.5 0.1 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDK40255.2 - 3.4e-07 30.6 0.3 0.04 14.2 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EDK40255.2 - 0.00019 21.9 0.4 0.0027 18.1 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDK40255.2 - 0.00028 20.9 0.1 0.087 12.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDK40255.2 - 0.0011 18.7 0.0 0.95 9.2 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 EDK40255.2 - 0.0013 18.3 0.2 0.0041 16.7 0.1 1.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EDK40255.2 - 0.0014 17.9 0.3 0.0047 16.2 0.2 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 EDK40255.2 - 0.0017 18.7 0.9 0.57 10.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDK40255.2 - 0.002 18.4 0.0 0.0042 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDK40255.2 - 0.0021 17.5 0.1 0.09 12.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDK40255.2 - 0.0081 16.7 0.0 0.023 15.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 EDK40255.2 - 0.012 15.6 0.0 2 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EDK40255.2 - 0.012 15.6 0.0 0.4 10.7 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DnaB_C PF03796.15 EDK40255.2 - 0.022 14.1 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 EDK40255.2 - 0.026 14.3 0.1 0.062 13.0 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_lid_4 PF17864.1 EDK40255.2 - 0.044 13.5 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain AAA_30 PF13604.6 EDK40255.2 - 0.047 13.4 0.1 6.9 6.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EDK40255.2 - 0.052 12.8 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 EDK40255.2 - 0.054 12.7 0.0 2.8 7.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_33 PF13671.6 EDK40255.2 - 0.08 13.1 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain GvpD PF07088.11 EDK40255.2 - 0.088 11.4 0.1 0.48 9.0 0.0 1.9 2 0 0 2 2 2 0 GvpD gas vesicle protein AAA_7 PF12775.7 EDK40255.2 - 0.13 11.8 0.3 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EDK40255.2 - 0.14 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 EDK40256.2 - 1.1e-85 287.2 0.0 1.3e-85 287.0 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EDK40256.2 - 0.00078 18.5 0.0 0.0022 17.0 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 EDK40256.2 - 0.0042 16.9 0.0 0.01 15.6 0.0 1.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop KAP_NTPase PF07693.14 EDK40256.2 - 0.018 14.3 0.0 0.11 11.7 0.0 2.1 2 1 1 3 3 3 0 KAP family P-loop domain RsgA_GTPase PF03193.16 EDK40256.2 - 0.02 14.8 0.1 0.3 11.0 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_10 PF12846.7 EDK40256.2 - 0.026 13.4 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.22 EDK40256.2 - 0.033 14.6 0.0 0.11 12.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 EDK40256.2 - 0.037 14.6 0.0 0.081 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 EDK40256.2 - 0.045 13.8 0.0 0.17 12.0 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase Fer4_NifH PF00142.18 EDK40256.2 - 0.047 13.1 0.0 0.14 11.6 0.0 1.7 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Kre28 PF17097.5 EDK40256.2 - 0.061 12.3 0.2 0.13 11.2 0.0 1.5 2 0 0 2 2 2 0 Spindle pole body component AAA_30 PF13604.6 EDK40256.2 - 0.067 12.9 0.0 0.14 11.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_31 PF13614.6 EDK40256.2 - 0.084 12.8 0.1 3.3 7.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDK40256.2 - 0.095 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EDK40256.2 - 0.16 12.0 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_7 PF12775.7 EDK40256.2 - 0.2 11.2 0.0 0.38 10.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Cation_efflux PF01545.21 EDK40257.2 - 1.1e-40 139.5 4.6 1.1e-40 139.5 4.6 2.7 2 1 0 2 2 2 1 Cation efflux family E1-E2_ATPase PF00122.20 EDK40257.2 - 0.89 9.1 15.4 12 5.3 0.0 4.1 4 0 0 4 4 4 0 E1-E2 ATPase His_Phos_1 PF00300.22 EDK40258.2 - 2.8e-05 23.9 0.0 0.3 10.8 0.0 3.0 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) PI3_PI4_kinase PF00454.27 EDK40259.2 - 1.2e-43 149.7 2.6 1.9e-41 142.5 0.0 3.8 3 1 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDK40259.2 - 4.2e-36 124.1 4.3 2.3e-22 79.3 0.4 2.6 2 0 0 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EDK40259.2 - 7.3e-25 87.5 0.0 1.7e-24 86.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 CoaE PF01121.20 EDK40260.2 - 1.9e-60 203.6 0.0 2.3e-60 203.3 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EDK40260.2 - 0.00013 22.5 0.0 0.00039 21.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDK40260.2 - 0.01 16.1 0.0 0.043 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDK40260.2 - 0.051 14.0 0.2 1.4 9.4 0.0 2.4 2 1 1 3 3 3 0 AAA domain SKI PF01202.22 EDK40260.2 - 0.083 13.0 0.1 6.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase OHCU_decarbox PF09349.10 EDK40260.2 - 0.13 12.8 0.0 3 8.3 0.1 2.2 1 1 1 2 2 2 0 OHCU decarboxylase ApbA_C PF08546.11 EDK40261.2 - 1.1e-33 116.1 0.2 1.7e-33 115.4 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDK40261.2 - 3.5e-28 98.2 0.0 5.1e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EDK40261.2 - 0.024 14.9 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EDK40261.2 - 0.052 13.6 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SET PF00856.28 EDK40262.2 - 9.8e-21 74.9 0.0 2.2e-20 73.7 0.0 1.6 1 1 0 1 1 1 1 SET domain Topoisom_bac PF01131.20 EDK40263.2 - 8.4e-108 361.0 0.0 1e-107 360.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDK40263.2 - 1.9e-19 69.8 0.0 1.4e-18 67.0 0.0 2.2 2 0 0 2 2 2 1 Toprim domain zf-CCCH PF00642.24 EDK40264.2 - 4.9e-08 32.7 1.8 9.5e-08 31.8 1.8 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK40264.2 - 1.8e-06 27.8 6.6 4e-06 26.7 6.6 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EDK40264.2 - 2.6e-06 27.1 1.8 5.3e-06 26.1 1.8 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EDK40264.2 - 9.5e-05 23.1 0.2 0.00018 22.2 0.2 1.4 1 0 0 1 1 1 1 Torus domain zf-CCCH_2 PF14608.6 EDK40264.2 - 0.32 11.6 4.4 0.69 10.5 4.4 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RSN1_7TM PF02714.15 EDK40265.2 - 2.8e-79 266.3 25.8 2.8e-79 266.3 25.8 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDK40265.2 - 2.7e-33 114.9 5.4 9.6e-33 113.2 5.4 2.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDK40265.2 - 2.8e-32 112.4 0.0 4.3e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter BtpA PF03437.15 EDK40265.2 - 0.19 11.1 0.0 0.74 9.2 0.0 1.8 2 0 0 2 2 2 0 BtpA family FTA4 PF13093.6 EDK40266.2 - 7.6e-27 94.5 16.2 1.5e-26 93.5 16.2 1.4 1 1 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Erf4 PF10256.9 EDK40266.2 - 0.1 12.7 0.2 0.73 10.0 0.1 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family PBP_dimer PF03717.15 EDK40266.2 - 0.41 11.0 5.6 12 6.2 5.6 2.1 1 1 0 1 1 1 0 Penicillin-binding Protein dimerisation domain Terminase_4 PF05119.12 EDK40266.2 - 0.75 10.3 4.0 0.56 10.7 0.1 2.4 2 1 0 2 2 2 0 Phage terminase, small subunit Glyco_hydro_18 PF00704.28 EDK40267.1 - 4.5e-39 135.0 4.8 6.1e-39 134.6 4.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EDK40267.1 - 1.4e-11 44.7 15.1 3.8e-11 43.3 15.1 1.8 1 0 0 1 1 1 1 Chitin recognition protein Ribosomal_60s PF00428.19 EDK40268.1 - 5.9e-27 94.1 11.0 7.1e-27 93.8 11.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_S19 PF00203.21 EDK40269.1 - 2.8e-33 113.6 0.1 3.3e-33 113.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Mito_carr PF00153.27 EDK40270.2 - 7e-56 186.2 5.5 8.9e-21 73.6 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein HTH_34 PF13601.6 EDK40271.2 - 0.072 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain GDPD_2 PF13653.6 EDK40271.2 - 0.15 12.6 0.3 0.29 11.6 0.3 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Mito_carr PF00153.27 EDK40272.2 - 1.7e-48 162.5 1.6 2.2e-15 56.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EDK40272.2 - 0.08 13.2 0.1 1.1 9.5 0.1 2.7 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase CDP-OH_P_tran_2 PF08009.11 EDK40272.2 - 2.3 8.2 7.6 3.1 7.8 0.1 3.2 3 0 0 3 3 3 0 CDP-alcohol phosphatidyltransferase 2 SPA PF08616.10 EDK40274.2 - 6e-34 116.4 0.1 1.8e-33 114.9 0.1 1.9 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EDK40274.2 - 2.7e-21 76.4 0.1 8.4e-21 74.8 0.1 1.7 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 EDK40274.2 - 1e-12 47.5 0.8 1.5e-07 30.5 0.0 2.6 2 1 0 2 2 2 2 Transport protein Avl9 DUF2347 PF09804.9 EDK40274.2 - 0.00021 21.0 0.1 0.067 12.8 0.1 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 EDK40274.2 - 0.075 13.0 1.7 4.3 7.3 0.1 2.9 2 1 0 2 2 2 0 DENN (AEX-3) domain zf-C2H2_4 PF13894.6 EDK40275.2 - 7.2e-06 26.4 11.1 0.0099 16.7 2.1 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK40275.2 - 7.8e-05 22.9 3.9 0.036 14.5 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EDK40275.2 - 0.00056 20.2 3.1 0.00056 20.2 3.1 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type CpXC PF14353.6 EDK40275.2 - 0.083 12.9 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 CpXC protein zf-H2C2_5 PF13909.6 EDK40275.2 - 0.099 12.4 7.7 0.093 12.5 4.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain RGS PF00615.19 EDK40276.2 - 5.5e-07 29.9 0.1 5e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain MerC PF03203.14 EDK40276.2 - 0.44 11.0 3.2 0.9 10.0 3.2 1.5 1 1 0 1 1 1 0 MerC mercury resistance protein Claudin_2 PF13903.6 EDK40276.2 - 1.5 8.5 7.5 0.11 12.3 1.9 1.7 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Ribosomal_L19e PF01280.20 EDK40277.1 - 2.9e-47 160.4 8.2 2.9e-47 160.4 8.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L19e DUF2423 PF10338.9 EDK40278.2 - 2.2e-18 66.2 9.9 2.2e-18 66.2 9.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) AIRC PF00731.20 EDK40279.2 - 2.2e-64 215.5 1.4 4.6e-64 214.5 1.4 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EDK40279.2 - 4.5e-58 195.6 0.0 7.1e-58 195.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EDK40279.2 - 8.6e-18 63.8 0.0 1.8e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 EDK40279.2 - 5.4e-05 22.8 0.0 0.00012 21.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain 2-Hacid_dh_C PF02826.19 EDK40279.2 - 0.0001 21.7 0.0 0.00023 20.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EDK40279.2 - 0.015 15.2 0.0 0.037 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H-binding CoA_binding_2 PF13380.6 EDK40279.2 - 0.016 15.7 1.3 16 6.1 0.0 3.7 2 1 1 3 3 3 0 CoA binding domain Dala_Dala_lig_C PF07478.13 EDK40279.2 - 0.017 14.6 0.0 0.1 12.1 0.0 2.1 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus NAD_binding_2 PF03446.15 EDK40279.2 - 0.032 14.4 0.1 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase PrpR_N PF06506.11 EDK40279.2 - 0.035 13.7 0.3 0.35 10.4 0.0 2.8 3 0 0 3 3 3 0 Propionate catabolism activator 3HCDH_N PF02737.18 EDK40279.2 - 0.098 12.5 0.1 0.64 9.9 0.0 2.4 2 1 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TEA PF01285.18 EDK40281.2 - 3.7e-27 94.2 0.1 1.4e-26 92.3 0.0 2.1 2 1 1 3 3 3 1 TEA/ATTS domain zf-HC5HC2H_2 PF13832.6 EDK40282.2 - 2.7e-32 111.2 4.9 2.7e-32 111.2 4.9 2.7 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDK40282.2 - 2.7e-28 98.1 2.4 2.7e-28 98.1 2.4 3.6 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EDK40282.2 - 1.3e-12 47.0 1.7 1.3e-12 47.0 1.7 2.6 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 EDK40282.2 - 5.5e-10 39.9 0.4 1.4e-09 38.5 0.4 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.29 EDK40282.2 - 1.6e-09 37.5 24.4 5.8e-09 35.7 9.0 2.9 2 0 0 2 2 2 2 PHD-finger C1_1 PF00130.22 EDK40282.2 - 1.5 8.7 16.9 0.21 11.5 2.3 3.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 EDK40282.2 - 3.1 8.2 26.0 0.12 12.7 8.3 3.5 3 1 0 3 3 3 0 RING-like domain CBF PF03914.17 EDK40283.2 - 1.1e-46 159.0 0.1 1.1e-46 159.0 0.1 3.4 3 1 0 3 3 3 1 CBF/Mak21 family DCP2 PF05026.13 EDK40283.2 - 0.041 14.2 0.1 0.14 12.5 0.1 1.9 1 0 0 1 1 1 0 Dcp2, box A domain Ras PF00071.22 EDK40284.2 - 1.3e-28 99.6 0.0 1.8e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40284.2 - 0.00025 21.2 0.0 0.00043 20.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EDK40284.2 - 0.001 18.8 0.2 0.0035 17.1 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK40284.2 - 0.075 13.4 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EDK40285.2 - 2.2e-62 210.8 0.0 3.5e-62 210.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40285.2 - 1.8e-35 122.5 0.0 3e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EDK40285.2 - 5e-23 81.0 11.0 9.1e-12 44.9 1.2 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EDK40285.2 - 9.3e-19 67.1 33.1 5.4e-11 42.2 13.5 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EDK40285.2 - 2.1e-13 50.7 1.8 2.1e-13 50.7 1.8 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EDK40285.2 - 2.4e-07 31.0 0.1 4.8e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EDK40285.2 - 0.00012 21.5 0.1 0.0006 19.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDK40285.2 - 0.00044 19.3 0.0 0.00093 18.2 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Uds1 PF15456.6 EDK40285.2 - 0.00088 19.4 1.5 0.0027 17.9 0.1 2.3 2 0 0 2 2 2 1 Up-regulated During Septation Pkinase_fungal PF17667.1 EDK40285.2 - 0.01 14.7 0.0 0.017 13.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase zf-RING_9 PF13901.6 EDK40285.2 - 5.1 7.0 26.5 0.54 10.2 6.7 2.9 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon C1_2 PF03107.16 EDK40285.2 - 6 7.3 25.8 8.4 6.8 12.0 2.6 2 0 0 2 2 2 0 C1 domain zinc_ribbon_16 PF17034.5 EDK40286.2 - 6.4e-32 110.4 9.5 1e-31 109.7 9.5 1.4 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EDK40286.2 - 0.00025 20.6 7.9 0.00025 20.6 7.9 2.6 3 1 0 3 3 3 1 Zinc-ribbon, C4HC2 type Lar_restr_allev PF14354.6 EDK40286.2 - 0.7 10.3 0.0 0.7 10.3 0.0 3.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar WD40 PF00400.32 EDK40287.2 - 0.0024 18.6 0.1 12 6.9 0.0 4.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Pkinase PF00069.25 EDK40288.2 - 3.3e-71 239.8 0.0 7.6e-71 238.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40288.2 - 2.3e-36 125.4 0.0 6.1e-36 124.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 EDK40288.2 - 1.4e-09 37.6 1.1 1.4e-09 37.6 1.1 3.0 2 0 0 2 2 2 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 EDK40288.2 - 0.00032 20.1 0.8 0.0015 17.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EDK40288.2 - 0.008 15.6 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK40288.2 - 0.12 12.3 1.2 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EDK40289.2 - 1.9e-68 230.7 0.0 2.7e-68 230.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40289.2 - 4e-31 108.3 0.0 5.6e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDK40289.2 - 7.8e-11 42.5 2.0 7.8e-11 42.5 2.0 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EDK40289.2 - 1.3e-05 24.3 0.1 1.3e-05 24.3 0.1 2.0 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 EDK40289.2 - 0.0048 16.5 0.1 2.7 7.5 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDK40289.2 - 0.0076 15.6 0.1 0.019 14.3 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDK40289.2 - 0.0087 15.4 0.1 0.018 14.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EDK40289.2 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family MRP-L28 PF09812.9 EDK40291.1 - 1.8e-29 103.0 3.9 2.1e-29 102.7 3.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 FTCD_C PF04961.12 EDK40291.1 - 0.049 13.4 0.1 0.058 13.2 0.1 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase HetR_C PF18460.1 EDK40291.1 - 0.073 13.0 0.4 0.1 12.5 0.4 1.3 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain DUF4337 PF14235.6 EDK40291.1 - 0.098 12.8 4.3 0.12 12.5 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) NuA4 PF09340.10 EDK40292.2 - 2.8e-25 88.0 3.6 4.4e-25 87.4 3.6 1.3 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 BBS2_C PF14782.6 EDK40292.2 - 0.031 13.1 0.1 0.031 13.1 0.1 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF5106 PF17127.4 EDK40292.2 - 0.044 14.1 0.5 0.077 13.3 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5106) Enolase_C PF00113.22 EDK40293.1 - 2.5e-154 512.8 0.0 3.4e-154 512.4 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EDK40293.1 - 2.4e-56 189.5 0.0 5.3e-56 188.4 0.0 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EDK40293.1 - 0.0011 18.6 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like Aminotran_5 PF00266.19 EDK40294.2 - 2.6e-11 43.1 0.0 5.8e-11 42.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EDK40294.2 - 0.0083 15.5 0.2 0.063 12.6 0.0 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDK40294.2 - 0.012 14.2 0.0 0.015 13.9 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Clat_adaptor_s PF01217.20 EDK40295.2 - 5.4e-44 149.6 2.8 6.4e-44 149.3 2.8 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CBP4 PF07960.11 EDK40296.2 - 4.4e-54 181.8 1.6 5.4e-54 181.5 1.6 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 EDK40296.2 - 0.0011 18.8 0.6 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 YscO-like PF16789.5 EDK40296.2 - 0.0033 17.5 2.6 0.0042 17.1 2.6 1.1 1 0 0 1 1 1 1 YscO-like protein SspO PF08175.12 EDK40296.2 - 0.012 16.1 1.4 0.012 16.1 1.4 1.7 2 0 0 2 2 2 0 Small acid-soluble spore protein O family MRP-S32 PF10210.9 EDK40296.2 - 0.059 13.9 3.0 0.35 11.5 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S32 Nnf1 PF03980.14 EDK40296.2 - 0.082 13.3 6.1 0.98 9.8 0.9 2.2 1 1 1 2 2 2 0 Nnf1 LAMTOR PF15454.6 EDK40296.2 - 0.12 13.0 0.2 0.12 13.0 0.2 2.2 2 1 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF2105 PF09878.9 EDK40296.2 - 0.17 11.6 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2105) Fungal_trans_2 PF11951.8 EDK40297.2 - 9e-12 44.5 0.7 1.2e-11 44.0 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40297.2 - 3.1e-06 27.2 8.8 3.1e-06 27.2 8.8 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ras PF00071.22 EDK40298.1 - 2e-49 167.3 0.0 2.3e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40298.1 - 4.4e-18 65.6 0.0 6.5e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK40298.1 - 1.5e-06 27.8 0.0 1.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family HATPase_c PF02518.26 EDK40299.2 - 8.5e-30 103.5 0.5 2.2e-29 102.2 0.5 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDK40299.2 - 1.4e-18 67.1 0.2 5.4e-18 65.2 0.1 2.2 2 0 0 2 2 2 1 Response regulator receiver domain Pkinase PF00069.25 EDK40299.2 - 4.4e-17 62.3 0.0 1e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain AAA_16 PF13191.6 EDK40299.2 - 4.1e-15 56.6 0.0 1.1e-14 55.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Pkinase_Tyr PF07714.17 EDK40299.2 - 4.7e-12 45.8 0.0 1e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HisKA PF00512.25 EDK40299.2 - 8.6e-12 44.9 0.0 3.2e-11 43.1 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.6 EDK40299.2 - 0.00044 20.6 0.0 0.0011 19.3 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EDK40299.2 - 0.0032 18.1 0.0 0.0075 16.9 0.0 1.6 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EDK40299.2 - 0.0086 15.9 0.1 0.024 14.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box_2 PF09011.10 EDK40300.2 - 6.4e-08 33.1 10.2 3.8e-07 30.6 3.5 4.3 3 3 0 3 3 3 2 HMG-box domain HMG_box PF00505.19 EDK40300.2 - 5e-05 23.6 1.5 5e-05 23.6 1.5 5.3 3 2 0 4 4 4 2 HMG (high mobility group) box Atg14 PF10186.9 EDK40300.2 - 0.013 14.6 16.8 0.023 13.8 16.8 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3470 PF11953.8 EDK40300.2 - 0.022 14.7 0.1 0.022 14.7 0.1 3.0 4 1 0 4 4 4 0 Domain of unknown function (DUF3470) YABBY PF04690.13 EDK40300.2 - 0.56 10.8 12.9 0.29 11.7 4.9 2.8 3 0 0 3 3 3 0 YABBY protein DUF3106 PF11304.8 EDK40300.2 - 1.6 9.2 25.7 9.6 6.7 1.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) DUF853 PF05872.12 EDK40300.2 - 2.2 6.7 7.4 3.2 6.2 7.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RbsD_FucU PF05025.13 EDK40300.2 - 6.6 7.2 7.3 1.4 9.3 3.4 1.9 3 0 0 3 3 3 0 RbsD / FucU transport protein family RNA_pol_Rpc4 PF05132.14 EDK40300.2 - 8.7 6.8 12.3 11 6.5 10.9 1.9 1 1 0 1 1 1 0 RNA polymerase III RPC4 ZYG-11_interact PF05884.12 EDK40300.2 - 9.4 5.6 5.2 14 5.0 0.0 2.7 1 1 1 2 2 2 0 Interactor of ZYG-11 Cpn60_TCP1 PF00118.24 EDK40301.2 - 5.1e-152 506.9 15.7 5.8e-152 506.8 15.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cyclin_N PF00134.23 EDK40302.2 - 9.9e-14 51.2 0.1 1.4e-13 50.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDK40302.2 - 1.1e-09 38.9 1.6 1.3e-09 38.6 0.0 1.8 2 1 0 2 2 2 1 Cyclin Codanin-1_C PF15296.6 EDK40302.2 - 0.011 15.7 0.3 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 Codanin-1 C-terminus Na_Ca_ex PF01699.24 EDK40303.2 - 7.6e-46 155.8 37.1 2.1e-23 83.0 9.4 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SE PF08491.10 EDK40304.2 - 5e-120 399.7 0.0 6.2e-120 399.4 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EDK40304.2 - 2.5e-15 56.6 0.0 1.7e-14 53.9 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDK40304.2 - 1.1e-09 38.4 0.5 0.0002 21.0 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK40304.2 - 2.2e-08 33.6 2.1 0.0013 17.9 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 EDK40304.2 - 1.5e-06 27.6 0.2 0.02 14.0 0.1 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 EDK40304.2 - 5.7e-06 25.9 3.6 0.00049 19.6 1.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EDK40304.2 - 0.00024 21.0 0.3 0.00045 20.2 0.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 EDK40304.2 - 0.00026 20.0 2.9 0.02 13.7 0.1 2.4 3 0 0 3 3 3 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EDK40304.2 - 0.0015 18.7 0.1 0.0044 17.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDK40304.2 - 0.0025 17.1 0.2 0.041 13.1 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.20 EDK40304.2 - 0.0026 17.8 0.1 0.0044 17.1 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 EDK40304.2 - 0.0045 16.3 1.3 0.014 14.6 1.3 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK40304.2 - 0.0062 17.1 2.7 0.036 14.6 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EDK40304.2 - 0.013 15.1 0.0 0.046 13.3 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 EDK40304.2 - 0.045 14.0 0.1 0.099 12.9 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Lycopene_cycl PF05834.12 EDK40304.2 - 0.057 12.4 0.6 0.44 9.5 0.2 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Sacchrp_dh_NADP PF03435.18 EDK40304.2 - 0.089 13.0 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain US10 PF17617.2 EDK40304.2 - 0.11 12.6 0.0 0.25 11.4 0.0 1.5 1 1 0 1 1 1 0 Viral unique short region 10 HI0933_like PF03486.14 EDK40304.2 - 0.11 11.2 0.1 0.16 10.6 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_2 PF03446.15 EDK40304.2 - 0.15 12.2 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.25 EDK40304.2 - 0.2 11.1 0.4 1.2 8.6 0.1 2.0 2 0 0 2 2 2 0 short chain dehydrogenase W2 PF02020.18 EDK40305.2 - 3.8e-16 59.0 5.9 7.5e-16 58.0 5.9 1.5 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 EDK40305.2 - 1.3e-08 34.8 0.0 2.5e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EDK40305.2 - 4.3e-08 32.6 16.2 0.00084 19.0 2.3 3.3 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 EDK40305.2 - 0.0026 16.0 4.5 0.0049 15.1 4.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 EDK40305.2 - 0.0027 18.1 0.0 0.0054 17.1 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EDK40305.2 - 0.078 12.7 13.0 0.099 12.4 1.6 3.8 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ctr PF04145.15 EDK40306.1 - 5.3e-24 85.5 14.1 9.4e-15 55.5 3.3 2.0 1 1 1 2 2 2 2 Ctr copper transporter family U3_assoc_6 PF08640.11 EDK40307.2 - 1.6e-30 105.0 5.3 7e-30 102.9 0.9 2.5 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EDK40307.2 - 4e-07 30.3 0.6 0.0026 18.4 0.2 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EDK40307.2 - 0.00061 19.0 0.7 0.015 14.4 0.7 2.2 1 1 0 1 1 1 1 NRDE-2, necessary for RNA interference TPR_17 PF13431.6 EDK40307.2 - 0.00065 19.9 0.1 12 6.5 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK40307.2 - 0.0015 19.1 0.7 0.033 14.8 0.5 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDK40307.2 - 0.0036 16.9 0.3 2.9 7.6 0.1 3.0 3 0 0 3 3 3 2 TPR repeat HAT PF02184.16 EDK40307.2 - 0.08 12.9 1.4 14 5.8 0.0 3.5 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat ZZ PF00569.17 EDK40309.2 - 2.5e-15 56.0 7.7 4.7e-15 55.1 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 EDK40309.2 - 7.1e-14 51.9 1.1 8.9e-13 48.4 0.1 2.9 2 1 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 EDK40309.2 - 4.4e-11 42.8 0.1 1.2e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDK40309.2 - 5.8e-08 32.9 0.1 2e-07 31.2 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Baculo_IE-1 PF05290.11 EDK40309.2 - 0.91 9.5 5.1 2.1 8.3 5.1 1.6 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Ribosomal_S17e PF00833.18 EDK40310.1 - 4.5e-44 149.3 0.1 5.4e-44 149.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 MIR PF02815.19 EDK40310.1 - 0.018 14.9 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 MIR domain DAO PF01266.24 EDK40311.2 - 5.6e-65 220.2 0.0 6.5e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDK40311.2 - 0.00012 22.2 0.0 0.00027 21.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK40311.2 - 0.0018 17.6 0.1 0.043 13.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDK40311.2 - 0.0025 17.1 0.1 0.0043 16.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family MCRA PF06100.11 EDK40311.2 - 0.0048 15.8 0.2 0.0091 14.8 0.0 1.5 2 0 0 2 2 2 1 MCRA family NAD_binding_9 PF13454.6 EDK40311.2 - 0.051 13.6 0.1 0.15 12.0 0.1 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF4538 PF15061.6 EDK40311.2 - 0.14 11.9 0.2 0.28 10.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Sacchrp_dh_NADP PF03435.18 EDK40311.2 - 0.15 12.3 0.2 0.31 11.3 0.2 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Trp_halogenase PF04820.14 EDK40311.2 - 0.21 10.4 0.2 0.3 9.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase CAP PF00188.26 EDK40313.2 - 1.4e-14 55.0 3.5 3.4e-14 53.8 3.5 1.6 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_M18 PF02127.15 EDK40314.2 - 2.1e-171 570.5 0.0 2.4e-171 570.3 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EDK40314.2 - 2.6e-09 36.5 0.1 0.00092 18.3 0.0 2.6 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase AA_permease PF00324.21 EDK40315.2 - 1.9e-118 396.1 43.9 2.2e-118 395.9 43.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40315.2 - 8.7e-36 123.7 50.6 1.1e-35 123.4 50.6 1.1 1 0 0 1 1 1 1 Amino acid permease PrgI PF12666.7 EDK40315.2 - 0.097 13.4 0.1 0.097 13.4 0.1 4.5 6 0 0 6 6 6 0 PrgI family protein Synaptobrevin PF00957.21 EDK40315.2 - 2 8.2 0.0 2 8.2 0.0 4.1 5 0 0 5 5 5 0 Synaptobrevin Rad60-SLD PF11976.8 EDK40316.2 - 1.5e-21 75.9 0.3 3e-21 75.0 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like E2R135 PF11570.8 EDK40317.2 - 0.14 12.5 0.2 0.22 11.8 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 ThiF PF00899.21 EDK40319.1 - 5.4e-61 206.1 0.0 7.8e-61 205.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EDK40319.1 - 6.6e-14 52.3 0.0 1.5e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain DUF2681 PF10883.8 EDK40319.1 - 0.02 15.3 0.3 0.038 14.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Shikimate_DH PF01488.20 EDK40319.1 - 0.08 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Mto2_bdg PF12808.7 EDK40319.1 - 0.23 11.8 3.5 0.53 10.6 3.5 1.6 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region PikAIV_N PF18605.1 EDK40319.1 - 1 9.0 4.0 1.6 8.4 4.0 1.3 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain NUC153 PF08159.12 EDK40320.2 - 2.4e-15 56.0 12.2 4.3e-15 55.2 2.0 3.3 3 0 0 3 3 3 2 NUC153 domain Adeno_PV PF03910.13 EDK40320.2 - 1.5 7.5 11.5 0.092 11.4 1.3 2.5 2 0 0 2 2 2 0 Adenovirus minor core protein PV TLD PF07534.16 EDK40321.2 - 1.4e-27 96.6 0.0 1.2e-25 90.4 0.0 2.6 1 1 0 1 1 1 1 TLD Kei1 PF08552.11 EDK40322.2 - 2.1e-35 122.3 11.8 2.5e-33 115.6 11.8 2.0 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 PepSY_TM_like_2 PF16357.5 EDK40322.2 - 0.007 16.4 0.1 0.012 15.6 0.1 1.3 1 0 0 1 1 1 1 Putative PepSY_TM-like DUF1129 PF06570.11 EDK40322.2 - 0.3 10.6 4.0 2.3 7.7 3.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) RIO1 PF01163.22 EDK40323.1 - 1.3e-72 243.3 4.7 1.3e-72 243.3 4.7 2.0 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 EDK40323.1 - 3.5e-05 23.3 0.5 3.5e-05 23.3 0.5 2.0 2 0 0 2 2 2 1 Protein kinase domain SURF2 PF05477.11 EDK40323.1 - 0.0031 17.2 11.8 0.0031 17.2 11.8 2.3 2 0 0 2 2 2 1 Surfeit locus protein 2 (SURF2) APH PF01636.23 EDK40323.1 - 0.0079 16.1 0.0 1 9.3 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family CDC45 PF02724.14 EDK40323.1 - 5.3 5.2 19.2 0.39 9.0 13.1 1.9 2 0 0 2 2 2 0 CDC45-like protein PAPS_reduct PF01507.19 EDK40324.2 - 0.078 13.0 0.3 0.08 13.0 0.3 1.2 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF4477 PF14780.6 EDK40324.2 - 0.095 12.3 4.2 0.47 10.0 4.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4477) VIT1 PF01988.19 EDK40324.2 - 0.19 11.6 0.4 0.24 11.2 0.4 1.1 1 0 0 1 1 1 0 VIT family V_ATPase_I PF01496.19 EDK40324.2 - 0.2 9.5 3.9 0.23 9.3 3.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5327 PF17261.2 EDK40324.2 - 7.8 7.3 14.5 0.6 10.9 8.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5327) DUF4491 PF14898.6 EDK40326.2 - 0.13 12.7 2.2 0.49 10.9 2.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4491) FA_desaturase PF00487.24 EDK40326.2 - 0.31 10.8 4.4 0.47 10.2 4.4 1.6 1 1 0 1 1 1 0 Fatty acid desaturase GWT1 PF06423.12 EDK40326.2 - 0.32 11.1 4.4 2.2 8.4 4.4 2.0 1 1 0 1 1 1 0 GWT1 HLH PF00010.26 EDK40327.2 - 3.7e-13 49.2 1.1 8e-13 48.1 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COP-gamma_platf PF08752.10 EDK40327.2 - 0.0041 17.3 0.3 0.0041 17.3 0.3 1.7 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain DUF1104 PF06518.11 EDK40327.2 - 2 8.8 5.9 0.44 10.9 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) Got1 PF04178.12 EDK40328.2 - 2e-32 111.9 15.9 2e-32 111.9 15.9 2.0 2 0 0 2 2 2 1 Got1/Sft2-like family PSS PF03034.15 EDK40328.2 - 0.012 15.4 0.6 0.012 15.4 0.6 2.3 1 1 1 2 2 2 0 Phosphatidyl serine synthase HIT PF01230.23 EDK40329.1 - 4.3e-23 81.9 0.0 6.1e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDK40329.1 - 6.2e-10 39.6 0.0 9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EDK40329.1 - 0.0087 15.9 0.8 0.016 15.1 0.8 1.7 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 AAA PF00004.29 EDK40330.2 - 2.2e-97 322.6 0.0 2e-47 160.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK40330.2 - 2.4e-25 88.0 4.6 4.9e-14 51.9 1.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDK40330.2 - 1.7e-19 69.8 1.2 7.2e-19 67.7 0.4 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EDK40330.2 - 1.1e-14 54.4 0.0 3.8e-06 26.7 0.0 3.5 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDK40330.2 - 2.6e-14 53.7 0.0 1.4e-07 31.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDK40330.2 - 7.4e-12 45.6 0.0 3.1e-06 27.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EDK40330.2 - 2.2e-11 44.4 0.4 0.00087 19.7 0.0 4.7 3 2 0 3 3 3 2 AAA ATPase domain CDC48_2 PF02933.17 EDK40330.2 - 3.5e-11 42.7 0.0 8.5e-11 41.5 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 EDK40330.2 - 3.2e-10 40.2 0.7 6.6e-05 22.9 0.0 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK40330.2 - 1.4e-09 38.3 3.8 0.06 13.6 0.0 4.9 3 2 1 4 4 4 2 AAA domain TIP49 PF06068.13 EDK40330.2 - 1e-08 34.8 2.7 0.00094 18.5 0.0 2.7 3 0 0 3 3 2 2 TIP49 P-loop domain Vps4_C PF09336.10 EDK40330.2 - 9.1e-08 32.0 0.5 4.2e-05 23.4 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain AAA_14 PF13173.6 EDK40330.2 - 1.8e-07 31.2 0.0 0.007 16.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 EDK40330.2 - 2.8e-07 30.4 0.1 0.017 14.8 0.0 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EDK40330.2 - 3.8e-07 30.5 0.0 0.03 14.7 0.0 3.3 4 0 0 4 4 2 2 RNA helicase Mg_chelatase PF01078.21 EDK40330.2 - 5.7e-07 29.1 0.5 0.032 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDK40330.2 - 2e-06 28.4 0.0 0.085 13.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EDK40330.2 - 8.8e-06 25.4 0.2 0.13 11.8 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ATPase PF06745.13 EDK40330.2 - 9.8e-06 25.1 0.7 1.1 8.6 0.0 3.5 3 0 0 3 3 3 2 KaiC ABC_tran PF00005.27 EDK40330.2 - 2.3e-05 24.9 0.1 0.19 12.2 0.0 3.7 3 1 0 3 3 2 1 ABC transporter AAA_24 PF13479.6 EDK40330.2 - 3e-05 23.9 0.1 0.076 12.7 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EDK40330.2 - 4.1e-05 23.9 0.0 0.46 10.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 EDK40330.2 - 5.2e-05 23.2 0.0 0.028 14.3 0.0 2.8 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_25 PF13481.6 EDK40330.2 - 5.2e-05 22.9 7.5 1.3 8.6 0.2 4.5 2 2 1 4 4 4 1 AAA domain PhoH PF02562.16 EDK40330.2 - 7.7e-05 22.2 0.7 0.12 11.9 0.1 2.6 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activat PF00158.26 EDK40330.2 - 8.6e-05 22.3 0.1 0.39 10.4 0.0 3.3 3 1 0 3 3 2 2 Sigma-54 interaction domain ResIII PF04851.15 EDK40330.2 - 0.00011 22.2 0.0 0.041 13.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 EDK40330.2 - 0.00016 22.1 0.2 0.45 10.9 0.0 3.0 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.13 EDK40330.2 - 0.00019 20.7 0.0 0.22 10.7 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EDK40330.2 - 0.00026 20.2 0.2 0.56 9.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 TsaE PF02367.17 EDK40330.2 - 0.00028 20.9 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EDK40330.2 - 0.0003 20.7 0.0 1 9.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EDK40330.2 - 0.00043 20.2 1.5 0.78 9.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 EDK40330.2 - 0.00092 18.5 0.0 0.8 8.9 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EDK40330.2 - 0.0023 17.7 0.6 2.6 7.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDK40330.2 - 0.0024 17.8 0.2 5.8 6.8 0.0 3.3 3 0 0 3 3 3 0 NACHT domain Zeta_toxin PF06414.12 EDK40330.2 - 0.003 16.9 0.1 1.3 8.3 0.0 3.0 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 EDK40330.2 - 0.0035 17.7 1.8 4.3 7.7 0.0 3.7 3 1 1 4 4 3 0 AAA domain ATPase_2 PF01637.18 EDK40330.2 - 0.0038 17.2 1.7 0.99 9.3 0.1 4.1 4 1 0 4 4 3 1 ATPase domain predominantly from Archaea IPT PF01745.16 EDK40330.2 - 0.014 14.8 0.2 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NB-ARC PF00931.22 EDK40330.2 - 0.014 14.6 0.4 2.8 7.1 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain T2SSE PF00437.20 EDK40330.2 - 0.017 14.2 0.0 3.4 6.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EDK40330.2 - 0.024 14.4 0.0 9.8 5.8 0.0 2.9 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 EDK40330.2 - 0.071 13.0 3.2 8.3 6.3 0.0 4.2 5 0 0 5 5 4 0 NTPase Sigma54_activ_2 PF14532.6 EDK40330.2 - 0.08 13.1 0.0 13 5.9 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EDK40330.2 - 0.15 11.8 0.0 17 5.0 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase eIF-1a PF01176.19 EDK40330.2 - 0.17 11.7 0.6 0.9 9.4 0.4 2.4 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 AAA_6 PF12774.7 EDK40330.2 - 0.2 10.6 0.3 7.3 5.5 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region HSP20 PF00011.21 EDK40330.2 - 1.3 9.2 4.2 2.6 8.2 0.1 3.2 4 0 0 4 4 2 0 Hsp20/alpha crystallin family Glycos_transf_2 PF00535.26 EDK40331.2 - 1.3e-33 116.2 0.0 1.6e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDK40331.2 - 1.3e-15 58.0 0.0 1.5e-15 57.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDK40331.2 - 6.1e-05 22.6 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EDK40331.2 - 0.00064 19.3 0.0 0.00086 18.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7N PF13733.6 EDK40331.2 - 0.045 13.4 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 ThiF PF00899.21 EDK40332.2 - 1.4e-63 214.5 0.0 2.1e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 EDK40332.2 - 1e-07 32.2 7.3 0.00068 19.6 0.0 2.8 2 1 0 3 3 3 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 EDK40332.2 - 4.2e-06 27.3 2.5 1e-05 26.0 0.5 2.5 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain DUF3969 PF13108.6 EDK40332.2 - 0.1 12.6 0.1 13 5.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3969) Profilin PF00235.19 EDK40333.1 - 2e-46 157.4 0.0 2.2e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Profilin DUF4410 PF14366.6 EDK40333.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) YCII PF03795.14 EDK40335.1 - 5.5e-05 23.5 0.0 6.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain YCII PF03795.14 EDK40336.1 - 0.00076 19.8 0.0 0.00098 19.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain zf-RanBP PF00641.18 EDK40337.2 - 5.7e-18 63.9 13.6 8.7e-11 40.9 2.3 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EDK40337.2 - 5.7e-09 35.7 0.0 1.4e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EDK40337.2 - 2.1e-07 31.6 0.0 6.3e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Exonuclease DUF719 PF05334.13 EDK40337.2 - 0.03 14.5 4.1 1.9 8.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Ferlin_C PF16165.5 EDK40337.2 - 0.061 13.3 3.8 1.7 8.6 3.1 2.2 2 0 0 2 2 2 0 Ferlin C-terminus TFIIA PF03153.13 EDK40337.2 - 0.52 10.2 14.8 0.33 10.9 9.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit WRNPLPNID PF15017.6 EDK40337.2 - 3.1 8.8 9.7 9.4 7.2 0.1 2.5 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DZR PF12773.7 EDK40337.2 - 3.6 7.7 8.3 25 5.0 8.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon OmpH PF03938.14 EDK40337.2 - 5.9 7.2 15.7 9 6.6 4.0 3.2 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) RSN1_7TM PF02714.15 EDK40338.2 - 2e-84 283.2 29.5 4.7e-84 281.9 29.5 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDK40338.2 - 6.5e-35 120.2 5.0 6.5e-35 120.2 5.0 2.4 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDK40338.2 - 1.2e-20 74.5 0.0 2.1e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Zn_clus PF00172.18 EDK40339.2 - 1.5e-10 41.0 7.4 2.3e-10 40.4 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Di19_C PF14571.6 EDK40339.2 - 4.8 7.8 10.7 0.52 10.9 4.6 2.2 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal PX PF00787.24 EDK40340.2 - 1e-10 41.6 1.0 4.3e-10 39.6 0.1 2.1 2 0 0 2 2 2 1 PX domain SH3_1 PF00018.28 EDK40340.2 - 1.2e-08 34.4 0.0 2.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK40340.2 - 7.8e-07 28.9 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK40340.2 - 7.9e-06 25.5 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EDK40340.2 - 0.041 14.2 1.5 0.41 11.0 0.0 2.8 3 0 0 3 3 3 0 Bacterial SH3 domain SH3_1 PF00018.28 EDK40341.2 - 5.5e-10 38.7 0.0 7.7e-09 35.0 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDK40341.2 - 3.1e-08 33.3 0.0 5.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PX PF00787.24 EDK40341.2 - 6.7e-08 32.5 0.1 6.4e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 PX domain SH3_2 PF07653.17 EDK40341.2 - 4.7e-05 23.0 0.0 0.0011 18.7 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Pkinase PF00069.25 EDK40343.2 - 3.1e-70 236.6 0.0 4.1e-70 236.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40343.2 - 1.3e-36 126.2 0.0 1.7e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK40343.2 - 1.2e-05 24.3 0.0 2.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDK40343.2 - 4.4e-05 22.9 0.0 0.0001 21.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDK40343.2 - 0.0029 16.6 0.1 0.0048 15.9 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 EDK40343.2 - 0.052 14.3 0.9 0.052 14.3 0.9 2.3 2 1 0 2 2 2 0 Protein kinase C terminal domain RHH_7 PF16777.5 EDK40343.2 - 0.13 12.7 0.4 9.3 6.7 0.1 2.8 2 1 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG 2TM PF13239.6 EDK40344.2 - 0.038 14.3 0.1 0.038 14.3 0.1 3.0 2 2 1 3 3 3 0 2TM domain P22_Tail-4 PF11650.8 EDK40344.2 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 P22 tail accessory factor DUF1218 PF06749.12 EDK40344.2 - 0.71 10.4 4.6 1.5 9.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) NapE PF06796.11 EDK40344.2 - 1.2 8.7 4.7 3.4 7.3 4.7 1.7 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Peptidase_C12 PF01088.21 EDK40345.2 - 7.1e-50 169.7 0.0 8e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SAC3_GANP PF03399.16 EDK40346.2 - 1.4e-20 73.9 12.3 2.7e-19 69.7 9.5 2.7 2 1 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EDK40346.2 - 0.0027 17.7 0.4 0.0027 17.7 0.4 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family RasGEF_N PF00618.20 EDK40346.2 - 1.3 9.3 5.7 3 8.1 0.0 3.3 2 1 0 3 3 3 0 RasGEF N-terminal motif DUF3867 PF12983.7 EDK40347.2 - 0.062 13.4 0.1 0.36 10.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3867) TIM21 PF08294.11 EDK40347.2 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 TIM21 Apolipo_F PF15148.6 EDK40347.2 - 0.078 12.5 0.3 2.7 7.4 0.0 2.3 1 1 1 2 2 2 0 Apolipoprotein F Sel1 PF08238.12 EDK40348.2 - 5e-08 33.4 1.1 0.06 14.0 0.1 3.5 3 0 0 3 3 3 2 Sel1 repeat MAP1B_neuraxin PF00414.17 EDK40348.2 - 0.16 11.6 4.9 0.36 10.5 4.9 1.6 1 0 0 1 1 1 0 Neuraxin and MAP1B repeat Peptidase_M1 PF01433.20 EDK40349.2 - 1.4e-50 171.9 0.6 2.8e-50 170.9 0.6 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EDK40349.2 - 1.6e-33 115.2 1.9 1.7e-33 115.1 0.6 1.8 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EDK40349.2 - 5.1e-26 92.0 0.0 9.3e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M48 PF01435.18 EDK40349.2 - 0.036 13.8 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M48 Peptidase_M61 PF05299.12 EDK40349.2 - 3.4 8.1 5.8 8.5 6.8 1.9 3.0 2 1 0 2 2 2 0 M61 glycyl aminopeptidase Ribosomal_S8 PF00410.19 EDK40350.1 - 7.7e-24 84.1 0.1 1.2e-23 83.5 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 DUF1086 PF06461.11 EDK40351.2 - 0.074 12.9 0.1 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1086) DUF1911 PF08929.10 EDK40351.2 - 0.12 13.2 0.1 0.28 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) DUF3660 PF12398.8 EDK40352.2 - 0.085 12.9 0.1 0.25 11.4 0.1 1.8 1 0 0 1 1 1 0 Receptor serine/threonine kinase DUF3445 PF11927.8 EDK40353.1 - 5.1e-67 225.8 0.4 6.4e-67 225.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) MFS_1 PF07690.16 EDK40354.2 - 1.7e-35 122.6 48.9 2.9e-23 82.4 27.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK40354.2 - 2.1e-06 26.9 41.2 5.7e-05 22.2 14.7 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter FRG PF08867.11 EDK40354.2 - 0.19 12.7 0.0 0.4 11.7 0.0 1.5 1 0 0 1 1 1 0 FRG domain DUF2012 PF09430.10 EDK40355.2 - 3.4e-05 24.0 0.0 6.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SOP4 PF17081.5 EDK40355.2 - 0.0041 16.7 0.0 0.14 11.7 0.0 2.1 1 1 0 1 1 1 1 Suppressor of PMA 1-7 protein TPT PF03151.16 EDK40356.2 - 8.3e-22 77.9 16.8 1.7e-13 50.6 7.0 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family Beach PF02138.18 EDK40357.2 - 8.1e-119 396.1 0.1 2e-118 394.7 0.1 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EDK40357.2 - 3.6e-11 43.0 0.0 1.1e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EDK40357.2 - 1.7e-06 28.3 0.1 5.1e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily WD40_like PF17005.5 EDK40357.2 - 0.00018 20.9 0.3 0.0004 19.8 0.3 1.5 1 0 0 1 1 1 1 WD40-like domain WD40 PF00400.32 EDK40357.2 - 0.11 13.4 2.5 3 8.8 0.0 4.3 4 0 0 4 4 4 0 WD domain, G-beta repeat UCH PF00443.29 EDK40358.2 - 9.9e-72 241.5 0.0 1.5e-70 237.7 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK40358.2 - 2.3e-11 43.8 1.8 0.00031 20.5 0.0 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EDK40358.2 - 2.2e-06 28.2 0.4 9.9e-06 26.1 0.1 2.4 2 0 0 2 2 2 1 DUSP domain CW_binding_1 PF01473.20 EDK40358.2 - 0.29 11.5 1.9 0.92 10.0 1.9 1.9 1 0 0 1 1 1 0 Putative cell wall binding repeat TF_Zn_Ribbon PF08271.12 EDK40358.2 - 2.8 7.5 4.3 0.9 9.1 0.3 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding RNase_PH PF01138.21 EDK40359.2 - 3e-17 63.3 0.2 5.3e-16 59.3 0.2 2.2 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF3113 PF11310.8 EDK40359.2 - 0.014 15.3 0.6 0.55 10.2 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3113) GATase_2 PF00310.21 EDK40360.2 - 1.3e-176 587.4 0.0 2e-176 586.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EDK40360.2 - 1e-147 492.1 2.8 6.6e-130 433.5 0.5 2.7 3 0 0 3 3 3 2 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EDK40360.2 - 2e-112 375.3 0.3 8e-112 373.3 0.1 2.0 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EDK40360.2 - 6.3e-82 273.8 4.1 1.1e-81 273.0 4.1 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 EDK40360.2 - 3.5e-22 78.3 0.2 9.4e-22 76.9 0.2 1.8 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 EDK40360.2 - 6e-22 78.2 0.2 4e-21 75.5 0.2 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK40360.2 - 1.3e-08 35.3 0.1 7.7e-05 23.2 0.1 3.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK40360.2 - 1.6e-07 31.5 0.0 6e-07 29.6 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EDK40360.2 - 7.5e-06 25.5 0.1 1.8e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase LAGLIDADG_3 PF14528.6 EDK40360.2 - 3.1e-05 24.2 0.0 0.0085 16.4 0.0 3.1 2 0 0 2 2 2 1 LAGLIDADG-like domain Hom_end PF05204.14 EDK40360.2 - 0.0002 21.5 1.9 0.075 13.2 0.0 4.0 4 0 0 4 4 3 1 Homing endonuclease FAD_oxidored PF12831.7 EDK40360.2 - 0.0002 20.8 0.1 0.00047 19.6 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK40360.2 - 0.00021 20.5 0.1 0.00043 19.5 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EDK40360.2 - 0.00033 19.5 0.3 0.00033 19.5 0.3 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDK40360.2 - 0.00083 18.7 0.2 0.14 11.4 0.0 2.7 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDK40360.2 - 0.0021 17.7 0.2 0.0021 17.7 0.2 2.4 2 1 1 3 3 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EDK40360.2 - 0.0021 17.3 0.4 0.0084 15.4 0.0 2.2 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 EDK40360.2 - 0.0027 17.0 0.1 0.0064 15.8 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 EDK40360.2 - 0.011 16.2 1.5 3 8.3 0.1 3.5 3 0 0 3 3 3 0 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 EDK40360.2 - 0.019 15.0 0.0 0.049 13.6 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AdoHcyase_NAD PF00670.21 EDK40360.2 - 0.036 14.1 0.1 3.1 7.8 0.0 2.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMN_dh PF01070.18 EDK40360.2 - 0.054 12.5 0.3 0.7 8.9 0.3 2.4 2 0 0 2 2 2 0 FMN-dependent dehydrogenase AlaDh_PNT_C PF01262.21 EDK40360.2 - 0.091 12.0 0.8 1.8 7.8 0.2 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDK40360.2 - 0.1 11.9 0.1 0.88 8.9 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EDK40360.2 - 0.12 11.5 1.0 0.25 10.4 0.0 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A FMO-like PF00743.19 EDK40360.2 - 0.16 10.3 0.0 0.99 7.7 0.0 2.0 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like Fasciclin PF02469.22 EDK40362.2 - 2.4e-05 24.6 0.0 6.6e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Fasciclin domain GrpB PF04229.14 EDK40362.2 - 0.029 14.6 0.1 0.055 13.7 0.1 1.4 1 0 0 1 1 1 0 GrpB protein HTH_WhiA PF02650.14 EDK40362.2 - 0.047 14.0 0.3 0.44 10.9 0.1 2.2 1 1 1 2 2 2 0 WhiA C-terminal HTH domain VHS PF00790.19 EDK40363.2 - 2.4e-40 137.6 0.0 5.8e-40 136.4 0.0 1.6 1 0 0 1 1 1 1 VHS domain Alpha_adaptinC2 PF02883.20 EDK40363.2 - 2.2e-18 66.6 0.4 2.2e-18 66.6 0.4 2.5 1 1 1 2 2 2 1 Adaptin C-terminal domain GAT PF03127.14 EDK40363.2 - 1e-16 61.0 0.5 4.9e-16 58.8 0.1 2.5 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 EDK40363.2 - 4.9e-05 22.8 0.2 0.00018 21.0 0.1 2.1 1 1 1 2 2 2 1 GGA N-GAT domain Exonuc_VII_L PF02601.15 EDK40363.2 - 0.036 13.6 0.5 0.095 12.3 0.4 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 EDK40363.2 - 0.48 10.7 6.0 2.3 8.5 2.7 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4112 PF13430.6 EDK40364.1 - 2e-33 114.8 0.5 2.6e-33 114.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Coq4 PF05019.13 EDK40365.2 - 6.4e-97 323.2 0.0 7.9e-97 322.9 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GyrI-like PF06445.15 EDK40365.2 - 0.09 13.1 0.1 0.39 11.0 0.0 1.9 2 0 0 2 2 2 0 GyrI-like small molecule binding domain FHA PF00498.26 EDK40366.2 - 3.1e-16 59.5 0.0 3.7e-14 52.8 0.0 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EDK40366.2 - 9.6e-05 22.6 0.0 0.00034 20.9 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain AT_hook PF02178.19 EDK40366.2 - 0.24 11.4 7.4 2.2 8.4 1.2 2.6 2 0 0 2 2 2 0 AT hook motif DASH_Spc19 PF08287.11 EDK40367.2 - 5.3e-36 123.9 7.3 7.4e-36 123.4 7.3 1.2 1 0 0 1 1 1 1 Spc19 PMEI PF04043.15 EDK40367.2 - 0.47 10.8 4.4 0.49 10.7 0.1 2.3 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor PXA PF02194.15 EDK40368.2 - 9.1e-24 84.4 3.8 1.8e-23 83.5 3.8 1.5 1 0 0 1 1 1 1 PXA domain BPL_LplA_LipB PF03099.19 EDK40369.2 - 3.4e-08 33.5 0.0 6.3e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family TMF_DNA_bd PF12329.8 EDK40369.2 - 0.019 15.0 0.0 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Rotamase PF00639.21 EDK40369.2 - 0.039 14.9 1.6 44 5.1 0.1 3.1 2 1 1 3 3 3 0 PPIC-type PPIASE domain GCR1_C PF12550.8 EDK40369.2 - 0.052 13.9 0.0 0.7 10.3 0.0 2.4 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes EMA PF02488.15 EDK40370.2 - 0.014 15.1 0.1 2.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Merozoite Antigen CybS PF05328.12 EDK40371.1 - 1.3e-55 186.7 0.1 1.8e-55 186.3 0.1 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit TPR_19 PF14559.6 EDK40372.2 - 0.0054 17.2 0.0 0.018 15.6 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK40372.2 - 0.047 14.5 0.0 0.48 11.4 0.1 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DHHC PF01529.20 EDK40373.2 - 6e-31 107.3 18.4 6e-31 107.3 18.4 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Nipped-B_C PF12830.7 EDK40374.2 - 8.3e-31 107.4 5.0 2.1e-30 106.1 1.9 3.1 2 2 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EDK40374.2 - 1.7e-14 53.8 6.4 2.7e-13 49.9 1.7 3.8 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 EDK40374.2 - 0.049 13.9 0.1 24 5.5 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat Cnd1 PF12717.7 EDK40374.2 - 0.17 11.9 3.1 0.37 10.8 0.4 3.1 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Drf_GBD PF06371.13 EDK40374.2 - 4 7.0 8.0 8.4 5.9 0.1 3.8 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain Metallophos PF00149.28 EDK40375.2 - 1.1e-10 42.4 1.3 2.4e-10 41.3 1.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SAS4 PF15460.6 EDK40376.2 - 4.7e-30 103.6 0.2 8.8e-30 102.7 0.2 1.5 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Sec10 PF07393.11 EDK40377.2 - 2.8e-189 631.0 17.3 3.4e-189 630.7 17.3 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF16 PF01519.16 EDK40377.2 - 0.0068 16.9 0.4 0.0068 16.9 0.4 2.7 2 1 0 2 2 2 1 Protein of unknown function DUF16 ubiquitin PF00240.23 EDK40378.1 - 3.4e-34 116.4 0.6 7.5e-34 115.3 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EDK40378.1 - 5e-26 90.6 2.2 1.2e-25 89.3 2.2 1.7 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EDK40378.1 - 2.1e-16 59.5 0.8 4.7e-16 58.4 0.7 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDK40378.1 - 2.2e-05 24.8 0.5 0.00012 22.4 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDK40378.1 - 0.0013 18.8 0.5 0.0028 17.8 0.5 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDK40378.1 - 0.0034 17.7 0.4 0.0076 16.6 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDK40378.1 - 0.0053 16.7 0.0 0.0079 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EDK40378.1 - 0.011 16.3 0.6 0.015 15.8 0.6 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDK40378.1 - 0.018 15.1 1.0 5.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDK40378.1 - 0.082 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain PRELI PF04707.14 EDK40379.2 - 2.2e-52 177.0 0.1 3.3e-52 176.5 0.1 1.2 1 0 0 1 1 1 1 PRELI-like family DDE_1 PF03184.19 EDK40380.2 - 2.6e-08 33.7 0.0 6.1e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease LicD PF04991.13 EDK40382.2 - 1.1e-24 87.8 12.2 1.5e-20 74.4 1.1 3.1 2 1 1 3 3 3 2 LicD family Peptidase_M16 PF00675.20 EDK40383.2 - 7.5e-49 165.5 0.1 1.1e-47 161.7 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDK40383.2 - 3.9e-31 108.5 0.0 3.4e-30 105.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain Ada3 PF10198.9 EDK40384.2 - 1.1e-40 138.8 4.6 2.1e-40 137.9 4.6 1.5 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 Cgr1 PF03879.14 EDK40384.2 - 0.08 13.3 3.6 0.16 12.4 3.6 1.4 1 0 0 1 1 1 0 Cgr1 family MRP-S28 PF10213.9 EDK40385.2 - 2.8e-41 140.9 2.0 6.6e-41 139.7 2.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Anillin_N PF16018.5 EDK40385.2 - 0.022 15.3 0.0 0.058 14.0 0.0 1.7 1 0 0 1 1 1 0 Anillin N-terminus SUV3_C PF12513.8 EDK40385.2 - 0.085 12.8 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal Isochorismatase PF00857.20 EDK40385.2 - 0.19 11.9 0.3 0.29 11.3 0.3 1.3 1 0 0 1 1 1 0 Isochorismatase family SRAP PF02586.14 EDK40386.2 - 7e-46 156.5 0.2 1.4e-45 155.5 0.2 1.5 1 1 0 1 1 1 1 SOS response associated peptidase (SRAP) PAF PF15715.5 EDK40386.2 - 2.2 8.9 13.1 4.7 7.8 13.1 1.5 1 0 0 1 1 1 0 PCNA-associated factor histone like domain MgsA_C PF12002.8 EDK40387.2 - 1e-56 191.5 0.0 2.4e-56 190.2 0.0 1.6 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EDK40387.2 - 1.7e-20 73.1 0.1 6.1e-20 71.4 0.0 2.0 1 1 0 1 1 1 1 AAA C-terminal domain Com_YlbF PF06133.11 EDK40387.2 - 0.051 14.2 5.1 0.21 12.2 0.0 2.5 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF2521 PF10730.9 EDK40387.2 - 0.064 13.3 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) zf-C2HC_2 PF13913.6 EDK40388.2 - 0.001 18.9 1.8 0.0017 18.2 1.8 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 EDK40388.2 - 0.0093 16.4 0.5 0.017 15.6 0.5 1.4 1 0 0 1 1 1 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2 PF00096.26 EDK40388.2 - 0.17 12.4 0.1 0.38 11.3 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type RNF220 PF15926.5 EDK40388.2 - 0.4 10.3 18.3 0.59 9.7 13.0 2.4 2 1 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 MscS_TM PF12794.7 EDK40388.2 - 2.2 7.1 2.9 3.4 6.4 2.9 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 OGG_N PF07934.12 EDK40389.2 - 8.2e-34 116.3 0.5 1.6e-33 115.3 0.5 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EDK40389.2 - 3.4e-16 59.6 0.0 5.9e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDK40389.2 - 0.012 15.5 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Zn_clus PF00172.18 EDK40390.2 - 1.1e-05 25.5 9.0 2.3e-05 24.4 9.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK40390.2 - 9.2e-05 21.6 4.5 0.00017 20.7 3.5 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EDK40391.2 - 1.1e-09 37.7 0.2 2.1e-09 36.8 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain HalX PF08663.10 EDK40391.2 - 0.17 12.3 0.1 0.39 11.1 0.1 1.6 1 0 0 1 1 1 0 HalX domain Arylsulfotran_2 PF14269.6 EDK40392.2 - 1.2e-88 297.4 7.8 1.7e-88 296.9 7.8 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EDK40392.2 - 7.3e-15 54.7 6.0 1.1e-14 54.1 6.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ PF01011.21 EDK40392.2 - 0.012 15.6 0.2 0.65 10.0 0.2 3.2 2 0 0 2 2 2 0 PQQ enzyme repeat Arylsulfotran_2 PF14269.6 EDK40393.2 - 2.2e-77 260.4 3.5 2.9e-77 260.0 3.5 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EDK40393.2 - 2.1e-18 66.4 2.6 5.3e-18 65.1 1.1 2.2 1 1 1 2 2 2 1 Arylsulfotransferase (ASST) PQQ PF01011.21 EDK40393.2 - 0.034 14.1 0.1 1.9 8.5 0.1 3.1 2 0 0 2 2 2 0 PQQ enzyme repeat MFS_1 PF07690.16 EDK40394.2 - 2.8e-40 138.3 42.0 5.4e-40 137.4 42.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK40394.2 - 1.1e-10 41.0 23.0 7.3e-10 38.3 16.3 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Halogen_Hydrol PF10112.9 EDK40394.2 - 1.1 9.3 2.8 1.2 9.1 0.0 2.5 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein MFS_1 PF07690.16 EDK40395.2 - 7.5e-28 97.5 14.7 1.1e-27 97.0 14.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3681 PF12442.8 EDK40395.2 - 0.1 13.1 0.2 0.26 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) YitT_membrane PF02588.15 EDK40395.2 - 0.44 9.9 7.4 0.13 11.6 2.7 2.3 2 0 0 2 2 2 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 MFS_1 PF07690.16 EDK40396.2 - 3.2e-21 75.6 14.3 3.9e-21 75.4 14.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CT_A_B PF02626.15 EDK40398.2 - 4.2e-65 220.0 0.0 5.8e-65 219.5 0.0 1.2 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 EDK40398.2 - 8e-44 149.7 0.0 1.4e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EDK40398.2 - 1.7e-30 105.3 0.0 2.9e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CT_C_D PF02682.16 EDK40398.2 - 3.8e-14 52.9 0.0 6.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Dala_Dala_lig_C PF07478.13 EDK40398.2 - 1.6e-06 27.8 0.0 2.5e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus LamB_YcsF PF03746.16 EDK40399.2 - 6.3e-84 281.4 0.0 7.3e-84 281.2 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family ComA PF02679.15 EDK40399.2 - 0.07 12.6 0.0 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) SH3_5 PF08460.10 EDK40399.2 - 0.076 13.1 0.1 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Bacterial SH3 domain Spo0M PF07070.11 EDK40399.2 - 0.14 11.7 0.1 9.3 5.7 0.0 2.1 1 1 1 2 2 2 0 SpoOM protein AP_endonuc_2 PF01261.24 EDK40399.2 - 0.15 11.5 0.0 18 4.7 0.0 2.3 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel SSF PF00474.17 EDK40400.2 - 1.6e-09 37.1 7.7 1.6e-09 37.1 7.7 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family SSF PF00474.17 EDK40401.2 - 1.4e-09 37.3 8.8 1.4e-09 37.3 8.8 1.5 1 1 0 1 1 1 1 Sodium:solute symporter family DUF2569 PF10754.9 EDK40401.2 - 1.9 8.9 11.0 4.3 7.8 11.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Bac_export_2 PF01312.19 EDK40401.2 - 2.3 7.3 10.9 4.7 6.3 10.9 1.4 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family AA_permease PF00324.21 EDK40402.1 - 2.4e-100 336.4 34.0 3e-100 336.1 34.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40402.1 - 5.2e-21 75.0 35.5 7.1e-21 74.5 35.5 1.0 1 0 0 1 1 1 1 Amino acid permease DHDPS PF00701.22 EDK40403.1 - 2.6e-66 223.3 0.0 2.9e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Peripla_BP_1 PF00532.21 EDK40403.1 - 0.044 13.2 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Fungal_trans PF04082.18 EDK40405.2 - 1.8e-24 86.2 0.5 4.5e-24 84.9 0.5 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40405.2 - 1.1e-10 41.4 8.4 2.2e-10 40.5 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.9 EDK40405.2 - 3.7 7.1 13.9 8.4 5.9 13.9 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FMN_dh PF01070.18 EDK40406.2 - 2.3e-119 398.5 0.0 2.7e-119 398.3 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EDK40406.2 - 1.6e-08 34.0 0.2 4.7e-08 32.4 0.1 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EDK40406.2 - 5.2e-07 29.4 0.0 6.8e-05 22.4 0.0 2.6 3 0 0 3 3 3 1 Histidine biosynthesis protein Glu_synthase PF01645.17 EDK40406.2 - 3e-06 26.6 0.2 1.5e-05 24.4 0.2 1.9 1 1 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EDK40406.2 - 3.7e-06 26.6 0.3 7.4e-06 25.6 0.3 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EDK40406.2 - 0.00045 19.6 0.6 0.092 12.0 0.0 2.5 1 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDK40406.2 - 0.0052 15.9 0.1 1.9 7.5 0.0 2.3 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EDK40406.2 - 0.011 14.9 0.2 0.52 9.5 0.0 2.1 1 1 0 2 2 2 0 Dihydroorotate dehydrogenase Aldedh PF00171.22 EDK40407.1 - 2.3e-102 342.9 0.2 2.7e-102 342.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF5063 PF16702.5 EDK40407.1 - 0.13 12.6 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) Glucosaminidase PF01832.20 EDK40407.1 - 0.14 12.6 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Aldedh PF00171.22 EDK40408.1 - 4.5e-56 190.3 0.1 5.1e-56 190.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Zn_clus PF00172.18 EDK40409.2 - 4.5e-09 36.3 11.3 9.9e-09 35.2 11.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EDK40410.2 - 3.6e-75 253.6 17.5 4.5e-75 253.2 17.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40410.2 - 6.2e-21 74.7 47.5 2.4e-20 72.8 25.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK40410.2 - 1.5e-06 27.1 15.0 0.0019 16.8 0.7 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EDK40410.2 - 7.6e-06 25.0 7.3 7.6e-06 25.0 7.3 2.4 2 1 0 2 2 2 1 MFS_1 like family ABC2_membrane_5 PF13346.6 EDK40410.2 - 0.3 10.6 17.9 2.9 7.4 0.0 3.6 3 0 0 3 3 3 0 ABC-2 family transporter protein Glyco_hydro_127 PF07944.12 EDK40411.2 - 1.3e-102 344.0 0.0 2.4e-102 343.1 0.0 1.3 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.13 EDK40411.2 - 0.047 12.8 0.0 0.41 9.7 0.0 2.3 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 ASL_C2 PF14698.6 EDK40411.2 - 0.18 12.5 0.0 0.46 11.3 0.0 1.6 1 0 0 1 1 1 0 Argininosuccinate lyase C-terminal UPF0047 PF01894.17 EDK40413.1 - 1.4e-36 125.2 0.0 1.6e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PHD PF00628.29 EDK40414.2 - 4.6e-10 39.2 5.9 1.1e-09 38.0 5.9 1.7 1 0 0 1 1 1 1 PHD-finger Neisseria_TspB PF05616.13 EDK40414.2 - 0.042 12.3 0.1 0.063 11.8 0.1 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Matrilin_ccoil PF10393.9 EDK40414.2 - 0.11 12.4 0.2 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Cep57_MT_bd PF06657.13 EDK40414.2 - 0.11 12.9 2.7 5.3 7.6 0.2 3.3 3 1 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Dynactin_p22 PF07426.11 EDK40414.2 - 0.44 10.4 4.5 0.32 10.8 0.2 2.6 2 1 1 3 3 3 0 Dynactin subunit p22 zf-HC5HC2H PF13771.6 EDK40414.2 - 8 6.8 7.9 3.1 8.1 3.8 2.4 1 1 1 2 2 2 0 PHD-like zinc-binding domain MFS_1 PF07690.16 EDK40415.2 - 1.9e-18 66.5 45.8 1.9e-14 53.4 24.1 2.9 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK40415.2 - 3.1e-05 22.6 29.0 0.0013 17.3 29.0 2.9 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EDK40415.2 - 3.6e-05 22.3 4.4 8.2e-05 21.2 4.4 1.5 1 0 0 1 1 1 1 Transmembrane secretion effector DUF872 PF05915.12 EDK40415.2 - 0.0043 17.2 0.1 0.021 15.0 0.1 2.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) S1FA PF04689.13 EDK40415.2 - 0.23 11.6 0.7 0.82 9.9 0.1 2.4 2 0 0 2 2 2 0 DNA binding protein S1FA CAF1C_H4-bd PF12265.8 EDK40416.2 - 1.3e-09 38.2 0.1 6.9e-09 35.8 0.1 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDK40416.2 - 3.4e-05 24.5 10.6 14 6.8 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Vps55 PF04133.14 EDK40417.2 - 2.4e-34 117.8 4.5 2.9e-34 117.5 4.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 EI24 PF07264.11 EDK40417.2 - 0.19 11.9 8.0 0.59 10.4 8.0 1.6 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF4349 PF14257.6 EDK40417.2 - 0.22 10.9 0.4 0.41 10.1 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Oxidored_q2 PF00420.24 EDK40417.2 - 0.22 11.2 4.6 0.36 10.5 0.1 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4191 PF13829.6 EDK40417.2 - 0.54 9.6 2.1 0.29 10.4 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) E1-E2_ATPase PF00122.20 EDK40417.2 - 0.58 9.7 3.5 0.46 10.0 1.6 1.7 2 0 0 2 2 2 0 E1-E2 ATPase CPBP PF02517.16 EDK40417.2 - 2.6 8.5 9.3 24 5.4 9.3 2.2 1 1 0 1 1 1 0 CPBP intramembrane metalloprotease DUF1077 PF06417.12 EDK40418.1 - 1.8e-46 157.0 4.6 2.3e-46 156.7 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) THUMP PF02926.17 EDK40419.1 - 8e-22 77.9 0.5 8e-22 77.9 0.5 2.1 2 0 0 2 2 2 1 THUMP domain F-box PF00646.33 EDK40420.2 - 0.00042 20.1 0.0 0.0011 18.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EDK40420.2 - 0.074 13.0 0.2 0.25 11.3 0.1 2.0 2 0 0 2 2 2 0 F-box-like YccV-like PF08755.11 EDK40420.2 - 0.12 12.9 1.4 0.71 10.4 0.1 2.6 2 0 0 2 2 2 0 Hemimethylated DNA-binding protein YccV like HSP70 PF00012.20 EDK40421.2 - 1.9e-224 746.4 5.8 2.3e-224 746.1 5.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDK40421.2 - 9.7e-19 67.3 2.6 2.2e-17 62.9 0.8 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EDK40421.2 - 2.2e-05 24.3 0.0 4.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EDK40421.2 - 0.0001 22.7 0.2 0.068 13.6 0.0 3.5 4 1 0 4 4 4 1 Cell division protein FtsA Raco_middle PF17651.1 EDK40421.2 - 0.8 9.4 3.1 7.9 6.1 0.0 3.3 4 0 0 4 4 4 0 RACo middle region Proteasome PF00227.26 EDK40422.2 - 7.5e-50 169.1 0.5 1.1e-49 168.5 0.5 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDK40422.2 - 7.3e-11 41.5 0.1 1.2e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Phage_CRI PF05144.14 EDK40422.2 - 0.012 15.0 0.1 0.023 14.0 0.1 1.4 1 0 0 1 1 1 0 Phage replication protein CRI Sec15 PF04091.12 EDK40423.2 - 5.5e-95 318.4 1.8 5.5e-95 318.4 1.8 1.8 2 1 0 2 2 2 1 Exocyst complex subunit Sec15-like LRR_5 PF13306.6 EDK40423.2 - 0.0016 18.4 1.2 0.028 14.4 0.0 2.8 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Sec8_exocyst PF04048.14 EDK40423.2 - 0.01 15.7 2.8 0.043 13.7 2.8 2.1 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain COG5 PF10392.9 EDK40423.2 - 0.046 13.9 2.0 0.19 11.9 1.8 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 BIV_Env PF05858.12 EDK40423.2 - 0.065 11.4 1.2 0.1 10.7 1.2 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) Mating_N PF12731.7 EDK40423.2 - 0.17 12.0 1.5 14 5.9 0.1 3.7 3 0 0 3 3 3 0 Mating-type protein beta 1 DASH_Duo1 PF08651.10 EDK40423.2 - 0.72 9.7 3.8 1.4 8.7 1.6 2.7 1 1 1 2 2 2 0 DASH complex subunit Duo1 Adaptin_binding PF10199.9 EDK40424.2 - 1.2e-14 55.0 6.2 2.7e-14 53.8 6.2 1.6 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Dynamin_N PF00350.23 EDK40425.2 - 4.6e-15 56.1 0.0 4.6e-15 56.1 0.0 2.9 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EDK40425.2 - 1.8e-11 44.1 0.0 9.8e-11 41.7 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK40425.2 - 6e-08 32.5 1.9 3.6e-05 23.4 2.6 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain cobW PF02492.19 EDK40425.2 - 0.00018 21.2 0.8 0.015 14.9 0.3 3.5 4 0 0 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDK40425.2 - 0.0034 17.3 5.7 0.61 10.0 0.6 3.3 2 1 0 2 2 2 2 RsgA GTPase Roc PF08477.13 EDK40425.2 - 0.0091 16.2 0.0 3.1 8.1 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ThiS-like PF14453.6 EDK40425.2 - 0.026 14.6 0.3 6.3 6.9 0.0 2.8 2 0 0 2 2 2 0 ThiS-like ubiquitin Exo_endo_phos PF03372.23 EDK40425.2 - 0.046 13.2 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family TsaE PF02367.17 EDK40425.2 - 0.094 12.7 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3883 PF13020.6 EDK40425.2 - 0.095 12.8 0.4 0.42 10.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3883) AAA_18 PF13238.6 EDK40425.2 - 0.11 13.1 0.0 0.58 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1904 PF08921.11 EDK40425.2 - 6.6 7.1 6.6 3.2 8.1 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1904) Ureidogly_lyase PF04115.12 EDK40426.2 - 3.2e-60 203.1 0.1 3.6e-60 202.9 0.1 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase adh_short PF00106.25 EDK40427.2 - 1.3e-36 126.0 0.4 1.6e-36 125.6 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK40427.2 - 2.4e-34 118.9 0.1 2.6e-34 118.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK40427.2 - 9.8e-14 51.7 0.2 1.6e-13 51.0 0.1 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK40427.2 - 4.9e-11 42.9 0.1 6.9e-11 42.4 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK40427.2 - 0.00075 19.0 0.2 0.0018 17.8 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EDK40427.2 - 0.00084 19.6 0.2 0.0046 17.2 0.1 2.0 2 0 0 2 2 2 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 EDK40427.2 - 0.0063 16.0 0.1 0.023 14.1 0.0 1.9 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 EDK40427.2 - 0.025 14.0 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EDK40427.2 - 0.064 12.8 0.6 0.15 11.5 0.5 1.7 1 1 1 2 2 2 0 NmrA-like family RmlD_sub_bind PF04321.17 EDK40427.2 - 0.12 11.4 0.1 0.43 9.6 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Nodulin-like PF06813.13 EDK40428.2 - 2.3e-17 63.3 5.8 2.3e-17 63.3 5.8 1.9 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 EDK40428.2 - 3.2e-16 59.2 21.9 3.2e-16 59.2 21.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UBX PF00789.20 EDK40429.2 - 2.2e-11 43.8 0.0 6.9e-11 42.2 0.0 1.9 1 0 0 1 1 1 1 UBX domain APG17 PF04108.12 EDK40429.2 - 0.0059 15.8 0.3 0.0086 15.2 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 Prenyltrans PF00432.21 EDK40430.2 - 1.2e-36 124.1 11.8 1.2e-10 40.9 0.0 4.9 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Y_phosphatase PF00102.27 EDK40431.2 - 8.9e-58 195.6 1.9 1.3e-57 195.1 1.9 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EDK40431.2 - 6.6e-19 68.4 0.0 1.2e-17 64.3 0.0 2.5 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EDK40431.2 - 0.00016 21.5 0.0 0.00058 19.7 0.0 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDK40431.2 - 0.012 15.6 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family YlbD_coat PF14071.6 EDK40431.2 - 0.026 14.8 0.1 5.6 7.2 0.1 2.8 3 0 0 3 3 3 0 Putative coat protein PTPlike_phytase PF14566.6 EDK40431.2 - 0.04 14.0 0.0 0.14 12.3 0.0 2.0 1 1 0 1 1 1 0 Inositol hexakisphosphate SOGA PF11365.8 EDK40432.2 - 0.0064 17.6 1.6 0.0064 17.6 1.6 2.7 2 1 0 2 2 2 1 Protein SOGA DUF3584 PF12128.8 EDK40432.2 - 0.027 12.0 20.1 0.029 11.9 20.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EDK40432.2 - 0.031 13.2 16.0 0.065 12.1 16.0 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein ERM PF00769.19 EDK40432.2 - 0.12 12.1 25.7 0.062 13.1 23.8 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family AAA_11 PF13086.6 EDK40432.2 - 0.2 11.4 8.9 0.35 10.6 8.9 1.4 1 0 0 1 1 1 0 AAA domain TSC22 PF01166.18 EDK40432.2 - 0.34 11.3 10.3 4 7.8 0.8 4.1 3 2 1 4 4 4 0 TSC-22/dip/bun family CENP-H PF05837.12 EDK40432.2 - 1.8 9.0 21.6 0.62 10.5 11.5 3.2 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Fib_alpha PF08702.10 EDK40432.2 - 3.7 7.7 20.1 1.1 9.5 15.0 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 EDK40432.2 - 4.7 7.6 13.4 19 5.6 5.2 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein DUF2418 PF10332.9 EDK40433.2 - 2e-24 85.9 0.2 2e-24 85.9 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) RNase_PH PF01138.21 EDK40434.2 - 6.4e-11 42.9 0.0 9.5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDK40434.2 - 0.0015 18.5 0.0 0.0033 17.4 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Nup35_RRM PF05172.13 EDK40435.2 - 3.8e-24 84.6 0.0 8.9e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EDK40435.2 - 0.00039 20.3 0.0 0.00079 19.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SpoU_methylase PF00588.19 EDK40436.2 - 6.9e-25 87.9 0.0 1.6e-24 86.7 0.0 1.7 1 0 0 1 1 1 1 SpoU rRNA Methylase family FAD_SOX PF18371.1 EDK40436.2 - 0.034 14.5 0.4 0.37 11.2 0.1 2.9 3 0 0 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase DUF3445 PF11927.8 EDK40437.2 - 5e-68 229.1 0.1 6.2e-68 228.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) PX PF00787.24 EDK40438.2 - 2.1e-19 69.6 0.9 7.5e-19 67.8 0.0 2.2 2 1 0 2 2 2 1 PX domain Snapin_Pallidin PF14712.6 EDK40438.2 - 0.11 12.9 8.4 1.5 9.3 0.3 3.9 4 0 0 4 4 4 0 Snapin/Pallidin Nup84_Nup100 PF04121.13 EDK40439.2 - 5.6e-183 609.9 0.6 6.4e-183 609.7 0.6 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Nup96 PF12110.8 EDK40439.2 - 0.013 14.6 0.1 0.84 8.7 0.0 2.8 3 0 0 3 3 3 0 Nuclear protein 96 RPN6_N PF18055.1 EDK40440.2 - 1.8e-38 131.5 1.1 1.8e-38 131.5 1.1 2.8 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EDK40440.2 - 1.1e-17 64.4 2.4 2.5e-17 63.3 0.1 2.7 3 1 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 EDK40440.2 - 1.9e-13 49.9 1.5 1.9e-13 49.9 1.5 2.0 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EDK40440.2 - 3.3e-06 27.3 10.0 0.012 15.9 1.6 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK40440.2 - 3.1e-05 23.5 2.7 0.0012 18.3 3.0 2.4 2 0 0 2 2 2 1 MalT-like TPR region SNAP PF14938.6 EDK40440.2 - 0.0064 15.9 0.8 0.0064 15.9 0.8 2.7 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EDK40440.2 - 0.0071 16.9 12.3 0.49 11.2 1.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDK40440.2 - 0.024 14.6 7.6 14 6.0 0.1 5.6 5 2 1 6 6 6 0 Tetratricopeptide repeat ANAPC5 PF12862.7 EDK40440.2 - 0.024 14.7 3.2 0.64 10.1 0.3 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_16 PF13432.6 EDK40440.2 - 0.025 15.2 1.0 2.6 8.8 0.0 3.7 3 2 0 3 3 3 0 Tetratricopeptide repeat DDRGK PF09756.9 EDK40440.2 - 0.04 13.5 0.1 0.1 12.2 0.1 1.7 1 0 0 1 1 1 0 DDRGK domain DUF3813 PF12758.7 EDK40440.2 - 0.19 12.1 2.9 21 5.6 0.1 3.4 3 1 0 3 3 2 0 Protein of unknown function (DUF3813) STN1_2 PF09170.10 EDK40440.2 - 1.8 8.7 7.0 1.1 9.5 0.2 2.8 2 1 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Methyltransf_23 PF13489.6 EDK40441.2 - 7.2e-22 78.0 0.0 1.3e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK40441.2 - 4.6e-14 52.9 0.1 1.4e-13 51.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK40441.2 - 3.7e-12 46.8 0.0 8.2e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK40441.2 - 5.1e-12 45.8 0.0 1e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK40441.2 - 7.7e-11 41.8 0.0 1.6e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EDK40441.2 - 1.1e-10 42.0 0.0 2.8e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK40441.2 - 0.15 11.6 0.5 1.4 8.5 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain SlyX PF04102.12 EDK40442.2 - 0.11 13.1 5.3 2.3 8.9 0.4 2.1 1 1 1 2 2 2 0 SlyX DivIC PF04977.15 EDK40442.2 - 0.39 10.5 5.0 0.33 10.8 0.4 2.1 1 1 1 2 2 2 0 Septum formation initiator PCRF PF03462.18 EDK40443.2 - 3.4e-49 167.3 0.9 6.1e-49 166.5 0.0 1.8 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EDK40443.2 - 7.8e-36 122.5 2.4 7.8e-36 122.5 2.4 2.0 2 0 0 2 2 2 1 RF-1 domain HEAT_2 PF13646.6 EDK40443.2 - 0.066 13.6 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 HEAT repeats JAKMIP_CC3 PF16034.5 EDK40443.2 - 0.067 13.1 2.9 0.089 12.7 0.2 2.2 2 0 0 2 2 2 0 JAKMIP CC3 domain EMP24_GP25L PF01105.24 EDK40444.2 - 1.4e-46 158.8 3.3 2.2e-46 158.1 3.3 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2207 PF09972.9 EDK40444.2 - 0.047 12.5 0.1 0.068 11.9 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ECR1_N PF14382.6 EDK40445.2 - 3.4e-16 58.7 0.0 8.4e-16 57.5 0.0 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EDK40445.2 - 5.5e-10 39.4 0.0 1.1e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EDK40445.2 - 0.019 15.6 0.3 17 6.0 0.0 3.3 3 1 1 4 4 4 0 Exosome component EXOSC1/CSL4 Met_10 PF02475.16 EDK40446.2 - 1.9e-70 236.7 0.1 3e-70 236.0 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.15 EDK40446.2 - 0.0006 19.6 0.0 0.00098 18.9 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.16 EDK40446.2 - 0.0054 15.9 0.0 0.0084 15.3 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF3150 PF11348.8 EDK40446.2 - 0.053 12.7 0.7 1.5 8.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3150) Rad4 PF03835.15 EDK40447.2 - 3.5e-20 72.2 0.5 3.1e-19 69.1 0.0 2.8 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EDK40447.2 - 2.7e-19 69.4 0.1 5.6e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EDK40447.2 - 1.3e-12 47.3 0.5 6.6e-12 45.1 0.1 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EDK40447.2 - 5.7e-06 27.2 0.4 5.7e-06 27.2 0.4 2.9 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 KxDL PF10241.9 EDK40447.2 - 1.8 8.9 4.8 0.78 10.1 1.4 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein RNase_H2_suC PF08615.11 EDK40448.2 - 1.1e-27 96.9 0.0 1.3e-27 96.7 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) 2OG-FeII_Oxy PF03171.20 EDK40449.2 - 2.8e-15 56.6 0.0 6.5e-15 55.5 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EDK40449.2 - 5.1e-15 56.3 0.0 9e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal ERG4_ERG24 PF01222.17 EDK40450.2 - 8.1e-142 473.0 12.3 9.2e-142 472.8 12.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EDK40450.2 - 0.00019 21.0 1.6 0.00047 19.7 1.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) MFS_1 PF07690.16 EDK40451.2 - 1.8e-26 92.9 32.5 2.8e-26 92.3 32.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Aldolase_II PF00596.21 EDK40452.2 - 1.9e-44 151.8 0.1 2.4e-44 151.5 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Peptidase_M20 PF01546.28 EDK40453.1 - 2.2e-33 115.7 0.1 3e-33 115.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK40453.1 - 1.1e-07 31.7 0.5 2.8e-07 30.4 0.5 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDK40453.1 - 0.014 15.0 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Epimerase PF01370.21 EDK40454.2 - 6.4e-17 61.8 0.0 9.4e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDK40454.2 - 5.8e-10 39.4 0.0 1.6e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EDK40454.2 - 8.2e-10 38.1 0.0 1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK40454.2 - 5.1e-09 35.7 0.2 0.00027 20.2 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein NmrA PF05368.13 EDK40454.2 - 2.5e-07 30.5 0.2 1.7e-06 27.8 0.2 2.3 2 1 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EDK40454.2 - 4.4e-07 29.6 0.1 6.6e-07 29.0 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDK40454.2 - 0.003 17.0 0.0 0.0068 15.9 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDK40454.2 - 0.059 13.3 0.2 1.1 9.2 0.2 2.2 1 1 0 1 1 1 0 KR domain Fungal_trans_2 PF11951.8 EDK40455.2 - 2e-73 247.4 0.8 2.7e-73 247.0 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40455.2 - 9.8e-06 25.6 15.3 9.8e-06 25.6 15.3 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 EDK40456.2 - 6e-32 109.8 1.5 9.8e-32 109.1 1.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK40456.2 - 4e-13 49.5 0.0 6.9e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK40456.2 - 1.5e-05 24.6 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus EamA PF00892.20 EDK40457.2 - 1.7e-12 47.7 33.3 2.2e-08 34.4 13.3 3.6 2 2 1 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 EDK40457.2 - 1.5e-08 34.2 8.2 1.5e-08 34.2 8.2 2.1 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 EDK40457.2 - 0.012 15.1 12.0 0.011 15.2 11.1 1.4 1 1 0 1 1 1 0 Solute carrier family 35 YSIRK_signal PF04650.17 EDK40457.2 - 6.9 6.6 5.9 37 4.3 0.1 3.1 3 0 0 3 3 3 0 YSIRK type signal peptide MFS_1 PF07690.16 EDK40458.2 - 6.4e-46 156.9 56.7 2.7e-44 151.5 56.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK40458.2 - 3.6e-10 39.3 13.3 3.6e-10 39.3 13.3 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 EDK40458.2 - 5.6 5.1 21.5 0.046 12.0 3.3 3.0 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EDK40459.2 - 1.3e-27 96.6 18.9 1.3e-27 96.6 18.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK40459.2 - 3.1e-05 23.4 0.9 7.9e-05 22.1 0.9 1.6 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB DUF347 PF03988.12 EDK40459.2 - 0.056 13.6 1.2 5.8 7.2 0.1 3.2 2 1 0 2 2 2 0 Repeat of Unknown Function (DUF347) FMO-like PF00743.19 EDK40460.2 - 2e-21 76.0 4.0 5.9e-10 38.2 0.1 3.0 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDK40460.2 - 4.3e-14 52.5 3.3 1.5e-11 44.1 1.2 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK40460.2 - 2.1e-10 40.3 0.5 4.7e-06 26.0 0.1 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EDK40460.2 - 5.9e-07 29.0 0.0 5.9e-06 25.7 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK40460.2 - 1.3e-06 28.5 0.4 6.9e-06 26.1 0.4 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EDK40460.2 - 5e-05 23.4 0.3 0.00014 22.0 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDK40460.2 - 0.041 13.5 3.5 0.15 11.6 1.0 2.2 2 1 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EDK40460.2 - 0.069 12.4 0.1 2.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.7 EDK40460.2 - 0.57 9.5 2.3 0.54 9.5 0.2 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase TauD PF02668.16 EDK40461.2 - 3.3e-52 177.9 0.1 4.7e-52 177.4 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Oxysterol_BP PF01237.18 EDK40462.2 - 1.6e-104 349.7 0.5 3.4e-104 348.7 0.5 1.5 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EDK40462.2 - 2.1e-33 114.5 0.3 4.3e-33 113.5 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Tir_receptor_C PF07489.11 EDK40462.2 - 2.7 7.9 7.4 5.2 7.0 0.1 2.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus zf-RING_UBOX PF13445.6 EDK40463.2 - 2.9e-09 36.8 9.1 2.9e-09 36.8 9.1 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDK40463.2 - 1e-06 28.5 6.2 1e-06 28.5 6.2 3.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK40463.2 - 1.3e-06 28.5 7.8 1.3e-06 28.5 7.8 2.9 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDK40463.2 - 1.9e-06 28.1 6.4 1.9e-06 28.1 6.4 3.4 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDK40463.2 - 4.9e-06 26.3 5.5 4.9e-06 26.3 5.5 3.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK40463.2 - 1.6e-05 24.7 4.7 1.6e-05 24.7 4.7 3.4 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EDK40463.2 - 6.3e-05 22.7 3.0 6.3e-05 22.7 3.0 2.4 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EDK40463.2 - 0.00012 21.9 5.8 0.00012 21.9 5.8 3.1 2 1 0 2 2 1 1 zinc-RING finger domain Sina PF03145.16 EDK40463.2 - 0.00077 19.5 18.5 0.033 14.2 6.9 3.3 1 1 2 3 3 3 2 Seven in absentia protein family Csm1_N PF18504.1 EDK40463.2 - 0.0037 17.6 1.0 0.16 12.4 0.1 2.6 2 0 0 2 2 2 1 Csm1 N-terminal domain zf-rbx1 PF12678.7 EDK40463.2 - 0.0093 16.2 3.8 0.0093 16.2 3.8 4.1 3 1 0 4 4 4 1 RING-H2 zinc finger domain HALZ PF02183.18 EDK40463.2 - 0.06 13.6 1.3 0.13 12.5 0.2 2.2 2 0 0 2 2 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 EDK40463.2 - 0.19 11.9 0.8 1.2 9.3 0.1 2.3 2 0 0 2 2 2 0 bZIP transcription factor GIT_CC PF16559.5 EDK40463.2 - 0.39 10.6 3.3 0.4 10.6 0.6 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor G_glu_transpept PF01019.21 EDK40464.2 - 3.9e-125 418.5 0.0 4.4e-125 418.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Sugar_tr PF00083.24 EDK40465.2 - 1.2e-05 24.4 9.8 2.7e-05 23.2 9.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40465.2 - 0.0046 15.9 8.8 0.0046 15.9 8.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3792 PF12670.7 EDK40465.2 - 0.038 14.1 12.8 2.1 8.5 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) DUF456 PF04306.13 EDK40465.2 - 0.29 11.4 7.1 0.037 14.3 3.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF456) DUF2157 PF09925.9 EDK40465.2 - 0.33 10.7 4.3 0.66 9.8 4.3 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) MFS_1 PF07690.16 EDK40466.1 - 5.9e-14 51.8 2.5 6.5e-14 51.6 2.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EDK40467.2 - 1.1e-16 60.6 0.4 2.3e-16 59.6 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MAGE PF01454.19 EDK40468.2 - 8.3e-27 94.3 0.0 1.1e-26 93.8 0.0 1.2 1 0 0 1 1 1 1 MAGE family FAD_binding_1 PF00667.20 EDK40469.2 - 5.5e-68 228.8 0.0 8e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EDK40469.2 - 8.8e-33 113.5 2.3 8.8e-33 113.5 2.3 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EDK40469.2 - 1.8e-24 86.4 0.1 1.3e-22 80.5 0.0 3.2 4 0 0 4 4 4 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.10 EDK40469.2 - 0.013 14.5 0.0 0.03 13.3 0.0 1.6 2 0 0 2 2 2 0 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.7 EDK40469.2 - 0.02 15.1 0.0 0.057 13.6 0.0 1.9 1 0 0 1 1 1 0 Flavodoxin domain NAD_binding_6 PF08030.12 EDK40469.2 - 0.12 12.5 0.0 0.63 10.1 0.0 2.2 2 1 0 2 2 2 0 Ferric reductase NAD binding domain Ins_P5_2-kin PF06090.12 EDK40470.2 - 2.7e-28 99.4 1.6 3.8e-28 98.9 1.6 1.2 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase AIM24 PF01987.17 EDK40471.2 - 8.4e-13 48.6 0.0 1.3e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 MKT1_C PF12246.8 EDK40472.2 - 1.1e-55 188.5 0.4 1.9e-55 187.8 0.4 1.4 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EDK40472.2 - 4.1e-27 94.4 0.9 1.2e-26 92.8 0.3 2.3 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EDK40472.2 - 2.1e-13 50.6 0.1 2.1e-11 44.2 0.0 3.1 3 0 0 3 3 3 1 XPG N-terminal domain XPG_I PF00867.18 EDK40472.2 - 9.2e-06 25.9 0.0 3.4e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 XPG I-region Xpo1 PF08389.12 EDK40473.2 - 0.002 18.2 5.3 0.002 18.2 5.3 4.3 4 1 0 4 4 4 1 Exportin 1-like protein Raco_middle PF17651.1 EDK40473.2 - 0.0052 16.5 0.4 0.43 10.2 0.0 2.6 2 0 0 2 2 2 1 RACo middle region IBN_N PF03810.19 EDK40473.2 - 0.0071 16.2 0.5 5.3 7.0 0.0 4.3 4 0 0 4 4 4 2 Importin-beta N-terminal domain Brix PF04427.18 EDK40474.1 - 5e-27 95.3 1.2 7.9e-27 94.6 1.2 1.3 1 0 0 1 1 1 1 Brix domain TBPIP_N PF15517.6 EDK40474.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 TBP-interacting protein N-terminus MaoC_dehydrat_N PF13452.6 EDK40475.2 - 1.1e-06 28.8 0.0 0.049 13.8 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 EDK40475.2 - 0.00025 20.6 0.0 0.00046 19.7 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain Glyco_hydro_38N PF01074.22 EDK40477.2 - 7.4e-78 261.8 0.7 1.1e-77 261.2 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EDK40477.2 - 1.3e-49 169.2 0.1 2.3e-49 168.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EDK40477.2 - 7.3e-24 83.7 0.0 1.5e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EDK40477.2 - 0.00058 19.9 0.1 0.0031 17.6 0.1 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Flocculin_t3 PF13928.6 EDK40478.1 - 3.3e-25 88.3 55.0 1.5e-13 51.0 23.5 4.4 5 1 0 5 5 5 2 Flocculin type 3 repeat HupH_C PF04809.13 EDK40478.1 - 0.044 13.5 0.3 0.1 12.3 0.3 1.7 1 1 0 1 1 1 0 HupH hydrogenase expression protein, C-terminal conserved region Membrane_bind PF14564.6 EDK40478.1 - 8.1 6.9 7.1 26 5.3 0.8 2.2 1 1 1 2 2 2 0 Membrane binding LMP PF04778.12 EDK40479.2 - 0.0012 18.7 6.2 0.0034 17.3 6.2 1.8 1 0 0 1 1 1 1 LMP repeated region Baculo_PEP_C PF04513.12 EDK40479.2 - 0.0066 16.5 2.8 0.0095 16.0 0.2 2.3 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_CTD PF16326.5 EDK40479.2 - 0.0095 16.2 4.2 0.92 9.8 0.0 3.5 2 1 0 3 3 3 1 ABC transporter C-terminal domain DUF4795 PF16043.5 EDK40479.2 - 0.039 13.6 2.3 0.098 12.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) NPV_P10 PF05531.12 EDK40479.2 - 0.088 13.3 8.8 0.13 12.8 2.6 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CK2S PF15011.6 EDK40479.2 - 0.12 12.2 1.0 0.77 9.6 1.0 2.2 1 1 0 1 1 1 0 Casein Kinase 2 substrate Muted PF14942.6 EDK40479.2 - 7.3 6.9 10.3 0.35 11.2 1.8 2.8 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein Redoxin PF08534.10 EDK40480.1 - 9.7e-35 119.4 0.0 1.1e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDK40480.1 - 2.4e-07 30.7 0.0 3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family PIG-F PF06699.11 EDK40481.2 - 2e-47 161.7 8.2 2.6e-47 161.3 8.2 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F DUF1211 PF06736.11 EDK40481.2 - 0.89 10.0 4.7 0.36 11.3 2.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1211) CPSF_A PF03178.15 EDK40482.2 - 2.1e-99 332.9 0.2 2.2e-97 326.2 0.1 2.3 2 0 0 2 2 2 2 CPSF A subunit region MMS1_N PF10433.9 EDK40482.2 - 1.4e-18 66.8 4.6 3.2e-18 65.7 4.6 1.6 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term HPS3_N PF14761.6 EDK40482.2 - 0.0067 16.0 0.4 1.3 8.5 0.0 3.6 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 Flocculin_t3 PF13928.6 EDK40483.2 - 1.3e-21 76.8 47.0 5.2e-15 55.7 21.2 9.0 5 4 2 7 7 7 3 Flocculin type 3 repeat Isochorismatase PF00857.20 EDK40484.2 - 2.7e-21 76.5 0.0 3.6e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Staphylcoagulse PF04022.12 EDK40484.2 - 1.2 8.7 4.0 11 5.7 0.6 2.4 2 0 0 2 2 2 0 Staphylocoagulase repeat ADH_zinc_N PF00107.26 EDK40485.2 - 0.00088 19.3 0.0 0.0027 17.7 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.24 EDK40485.2 - 0.05 14.0 0.0 0.099 13.1 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 EDK40485.2 - 0.086 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Thioredoxin PF00085.20 EDK40486.2 - 3.3e-15 55.9 0.0 2.5e-10 40.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 EDK40486.2 - 0.00012 22.3 1.5 0.062 13.6 0.2 3.0 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDK40486.2 - 0.00036 21.0 0.4 0.2 12.1 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like domain TraF PF13728.6 EDK40486.2 - 0.0004 20.3 0.0 0.00071 19.5 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein ER_lumen_recept PF00810.18 EDK40487.1 - 7.5e-52 176.1 8.0 1.3e-51 175.3 8.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EDK40487.1 - 0.25 11.2 9.7 4.4 7.1 0.2 4.3 2 1 2 4 4 4 0 PQ loop repeat Proteasome PF00227.26 EDK40488.2 - 1.2e-36 126.0 0.1 7.1e-36 123.5 0.1 1.8 1 1 0 1 1 1 1 Proteasome subunit zf-Tim10_DDP PF02953.15 EDK40489.2 - 1.4e-25 88.7 0.6 1.8e-25 88.4 0.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MFS_1 PF07690.16 EDK40490.2 - 4.7e-14 52.1 20.1 6.8e-14 51.5 20.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK40491.2 - 1.6e-19 70.1 14.9 2.2e-19 69.6 14.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDK40491.2 - 0.63 9.7 5.9 0.096 12.4 1.8 1.8 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EDK40492.1 - 0.00096 18.2 0.3 0.0012 17.8 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK40493.2 - 1.7e-07 30.5 9.3 1.7e-07 30.5 9.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily TMEM132D_C PF15706.5 EDK40493.2 - 0.0016 18.2 0.2 0.043 13.6 0.0 2.3 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ctr PF04145.15 EDK40494.1 - 4e-36 124.9 1.9 4.7e-36 124.6 1.9 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF2530 PF10745.9 EDK40494.1 - 0.8 10.0 3.3 2.8 8.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) ATP-synt_I PF03899.15 EDK40494.1 - 2 8.8 10.2 0.61 10.5 0.2 2.2 2 0 0 2 2 2 0 ATP synthase I chain DUF676 PF05057.14 EDK40495.2 - 4.9e-39 134.1 0.1 7.2e-39 133.6 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EDK40495.2 - 4e-05 23.6 0.0 6.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EDK40495.2 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase PF00151.19 EDK40495.2 - 0.012 14.9 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 0 Lipase Lipase_3 PF01764.25 EDK40495.2 - 0.016 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_1 PF00561.20 EDK40495.2 - 0.017 14.8 0.1 0.054 13.1 0.1 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold DLH PF01738.18 EDK40495.2 - 0.039 13.5 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF1890 PF09001.11 EDK40495.2 - 0.094 13.1 0.0 0.33 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1890) Melibiase_2 PF16499.5 EDK40496.2 - 2.9e-61 207.1 8.0 1.8e-60 204.5 8.0 2.0 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EDK40496.2 - 2.9e-08 33.6 2.2 9.2e-08 32.1 2.2 1.8 1 1 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EDK40496.2 - 2e-06 27.0 0.0 1.6e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Melibiase Epimerase PF01370.21 EDK40497.2 - 6.1e-18 65.2 0.0 8.9e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK40497.2 - 1.4e-10 40.7 0.0 1.9e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDK40497.2 - 4.6e-05 23.0 0.1 0.00017 21.1 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDK40497.2 - 5.2e-05 23.2 0.0 7.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDK40497.2 - 0.0026 17.4 0.1 0.016 14.8 0.0 2.1 2 1 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 EDK40497.2 - 0.003 16.8 0.1 0.63 9.2 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Rho_RNA_bind PF07497.12 EDK40497.2 - 0.0085 15.9 0.0 0.26 11.2 0.0 2.3 2 0 0 2 2 2 1 Rho termination factor, RNA-binding domain MucB_RseB PF03888.14 EDK40497.2 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 MucB/RseB N-terminal domain Gp_dh_C PF02800.20 EDK40498.2 - 2.3e-67 225.5 0.0 3.2e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDK40498.2 - 2.9e-39 133.5 0.0 6e-39 132.5 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EDK40498.2 - 0.02 15.0 0.2 0.077 13.1 0.2 2.2 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Rossmann-like PF10727.9 EDK40498.2 - 0.042 13.7 0.1 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Rossmann-like domain 2-Hacid_dh_C PF02826.19 EDK40498.2 - 0.051 12.9 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Peptidase_S15 PF02129.18 EDK40499.2 - 2.6e-55 187.9 0.9 3.8e-55 187.4 0.9 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EDK40499.2 - 2.3e-27 96.4 0.0 5.1e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 EDK40499.2 - 0.00037 19.9 0.0 0.00061 19.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK40499.2 - 0.079 12.6 0.0 0.18 11.4 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Sugar_tr PF00083.24 EDK40500.2 - 8.8e-21 74.3 21.6 1.6e-20 73.4 21.6 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40500.2 - 1.5e-20 73.5 28.6 6.7e-20 71.3 21.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily EXS PF03124.14 EDK40501.2 - 1.7e-85 287.3 25.7 1.7e-85 287.3 25.7 1.5 2 0 0 2 2 2 1 EXS family SPX PF03105.19 EDK40501.2 - 1.7e-23 84.2 9.0 1e-19 71.7 5.5 2.3 1 1 1 2 2 2 2 SPX domain DUF755 PF05501.11 EDK40501.2 - 0.00092 19.5 4.8 0.0021 18.3 4.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF755) AnmK PF03702.14 EDK40502.2 - 1.2e-84 284.5 0.0 1.5e-84 284.2 0.0 1.1 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase MFS_1 PF07690.16 EDK40503.2 - 3.3e-13 49.3 32.8 3.3e-13 49.3 32.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EDK40503.2 - 1.2e-09 38.1 7.1 1.2e-09 38.1 7.1 2.7 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 CPP1-like PF11833.8 EDK40503.2 - 2.4 7.7 8.6 0.82 9.3 1.3 2.7 2 1 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Fungal_trans PF04082.18 EDK40504.2 - 4.7e-29 101.2 1.2 6.8e-29 100.7 1.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40504.2 - 1.7e-08 34.4 13.4 1.7e-08 34.4 13.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sars6 PF12133.8 EDK40504.2 - 0.12 12.3 0.5 0.5 10.3 0.2 2.1 2 0 0 2 2 2 0 Open reading frame 6 from SARS coronavirus Pyr_redox_2 PF07992.14 EDK40505.2 - 1.5e-48 165.6 0.0 2e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK40505.2 - 1.7e-10 41.3 0.0 2.6e-09 37.5 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EDK40505.2 - 0.02 15.1 0.0 0.05 13.8 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Tegument_dsDNA PF12818.7 EDK40506.2 - 0.0095 15.1 0.1 0.016 14.4 0.1 1.3 1 0 0 1 1 1 1 dsDNA viral tegument protein LRR_4 PF12799.7 EDK40507.2 - 1.2e-06 28.7 37.2 0.045 14.2 0.1 10.3 7 5 2 10 10 10 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK40507.2 - 2.9e-06 27.0 1.0 2.9e-06 27.0 1.0 7.3 6 1 3 9 9 9 2 Leucine rich repeat FNIP PF05725.12 EDK40507.2 - 0.0002 21.5 20.6 0.16 12.2 0.1 7.2 8 1 1 9 9 9 3 FNIP Repeat LRR_5 PF13306.6 EDK40507.2 - 0.012 15.6 4.3 1.9 8.5 0.0 4.4 3 1 1 4 4 4 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EDK40507.2 - 7.3 6.9 17.2 93 3.5 0.1 8.1 10 0 0 10 10 10 0 Leucine Rich repeat ChapFlgA_N PF17656.1 EDK40508.2 - 0.13 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 FlgA N-terminal domain DUF917 PF06032.12 EDK40509.2 - 1.1e-107 359.9 0.0 2.2e-107 359.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EDK40509.2 - 6.5e-35 120.4 0.9 4.1e-31 108.1 0.0 3.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EDK40509.2 - 2e-28 99.5 9.8 1.8e-26 93.1 4.0 3.6 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase MutL PF13941.6 EDK40509.2 - 0.00014 20.6 0.9 0.034 12.7 0.1 2.3 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.20 EDK40509.2 - 0.5 9.8 4.9 0.27 10.7 0.1 2.9 3 1 2 5 5 5 0 BadF/BadG/BcrA/BcrD ATPase family Transp_cyt_pur PF02133.15 EDK40510.1 - 2e-71 241.1 34.8 2.3e-71 240.9 34.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin NPCC PF08058.11 EDK40510.1 - 0.15 12.1 0.4 1.7 8.7 0.0 2.7 3 1 0 3 3 3 0 Nuclear pore complex component F-box PF00646.33 EDK40511.2 - 0.0025 17.7 0.9 0.022 14.6 0.2 2.9 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 EDK40511.2 - 0.015 15.7 17.1 2 8.9 0.0 6.8 7 1 1 8 8 8 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EDK40511.2 - 0.057 13.3 0.3 0.34 10.8 0.3 2.5 1 1 0 1 1 1 0 F-box-like Chloroplast_duf PF14476.6 EDK40511.2 - 0.25 10.3 0.0 0.42 9.5 0.0 1.2 1 0 0 1 1 1 0 Petal formation-expressed LRR_8 PF13855.6 EDK40511.2 - 1.9 8.3 9.1 3.1 7.7 0.5 4.9 4 1 1 5 5 5 0 Leucine rich repeat DUF3452 PF11934.8 EDK40512.2 - 0.075 12.6 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) Polyketide_cyc2 PF10604.9 EDK40513.2 - 3e-10 40.5 0.0 3.4e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sugar_tr PF00083.24 EDK40514.2 - 2.1e-62 211.5 11.9 2.3e-62 211.3 11.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40514.2 - 1.1e-09 37.7 25.3 1e-05 24.6 7.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1075 PF06388.11 EDK40515.2 - 0.21 11.7 1.0 0.33 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1075) MFS_1 PF07690.16 EDK40516.1 - 0.00035 19.6 8.5 0.00035 19.6 8.5 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily PelG PF16933.5 EDK40516.1 - 0.00076 18.4 6.1 0.00092 18.2 6.1 1.1 1 0 0 1 1 1 1 Putative exopolysaccharide Exporter (EPS-E) DUF1003 PF06210.11 EDK40516.1 - 0.0079 16.3 0.3 1 9.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1003) Acyl_transf_3 PF01757.22 EDK40516.1 - 0.028 13.5 5.1 0.036 13.1 5.1 1.0 1 0 0 1 1 1 0 Acyltransferase family EcsB PF05975.12 EDK40516.1 - 0.043 12.7 1.8 0.055 12.3 1.8 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DMT_YdcZ PF04657.13 EDK40516.1 - 0.068 13.5 5.4 0.21 11.9 0.1 2.3 1 1 1 2 2 2 0 Putative inner membrane exporter, YdcZ MgtC PF02308.16 EDK40516.1 - 0.14 12.5 7.4 0.51 10.7 7.5 1.8 1 1 1 2 2 2 0 MgtC family PetM PF08041.11 EDK40516.1 - 0.83 9.3 3.3 2 8.1 3.3 1.7 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Peptidase_U4 PF03419.13 EDK40516.1 - 1.1 8.5 9.0 1.7 7.8 9.0 1.3 1 1 0 1 1 1 0 Sporulation factor SpoIIGA CPP1-like PF11833.8 EDK40516.1 - 3.7 7.2 9.0 2.2 7.9 7.4 1.4 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like MFS_1 PF07690.16 EDK40517.1 - 4.9e-23 81.6 15.2 5.8e-23 81.4 15.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK40517.1 - 7.4e-07 28.8 8.9 1e-06 28.3 8.9 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Cpn10 PF00166.21 EDK40517.1 - 0.071 13.2 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit DVL PF08137.12 EDK40517.1 - 0.23 11.4 1.5 0.61 10.0 1.5 1.7 1 0 0 1 1 1 0 DVL family MFS_1 PF07690.16 EDK40518.1 - 1.1e-33 116.7 30.3 1.1e-33 116.7 30.3 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DAO PF01266.24 EDK40519.1 - 3.8e-17 62.9 0.0 4.8e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDK40519.1 - 0.00012 22.2 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EDK40519.1 - 0.017 14.2 0.0 0.025 13.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EDK40519.1 - 0.028 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDK40519.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EDK40519.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DAO PF01266.24 EDK40520.1 - 9.3e-05 22.2 0.0 0.0001 22.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA_C PF08546.11 EDK40522.1 - 8.2e-29 100.4 0.0 1.3e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDK40522.1 - 0.0087 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_11 PF14833.6 EDK40522.1 - 0.13 12.5 0.0 2.5 8.4 0.0 2.1 1 1 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Aminotran_1_2 PF00155.21 EDK40523.2 - 2.4e-15 56.6 0.0 3e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDK40523.2 - 0.033 13.5 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDK40523.2 - 0.091 12.0 0.1 2.7 7.2 0.0 2.6 2 1 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Amdase PF17645.1 EDK40524.1 - 0.014 15.1 0.0 2.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Arylmalonate decarboxylase Asp_Glu_race PF01177.22 EDK40524.1 - 0.063 13.1 0.1 0.47 10.3 0.1 1.9 1 1 1 2 2 2 0 Asp/Glu/Hydantoin racemase Fungal_trans PF04082.18 EDK40525.2 - 2.5e-21 75.9 0.4 5e-21 74.9 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40525.2 - 1.5e-09 37.8 8.7 2.8e-09 36.9 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SKA1 PF07160.12 EDK40525.2 - 0.15 11.8 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Methyltransf_31 PF13847.6 EDK40526.2 - 4.7e-29 101.2 0.0 6.6e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK40526.2 - 2.2e-27 95.5 0.1 5.2e-27 94.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK40526.2 - 3.6e-25 88.5 0.0 6.3e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK40526.2 - 1.5e-21 76.8 0.0 2.3e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EDK40526.2 - 9.8e-15 55.1 0.0 1.8e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK40526.2 - 7.4e-12 45.4 0.0 8.7e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK40526.2 - 1.8e-07 30.8 0.0 3.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EDK40526.2 - 5e-06 26.4 0.0 6.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EDK40526.2 - 7.6e-06 25.5 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MetW PF07021.12 EDK40526.2 - 7.8e-06 25.6 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_PK PF05891.12 EDK40526.2 - 1.5e-05 24.6 0.0 2.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PrmA PF06325.13 EDK40526.2 - 3.4e-05 23.4 0.0 5.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_8 PF05148.15 EDK40526.2 - 0.00031 20.7 0.1 0.0045 16.9 0.1 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase FtsJ PF01728.19 EDK40526.2 - 0.00038 20.6 0.0 0.004 17.3 0.0 2.1 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_9 PF08003.11 EDK40526.2 - 0.00041 19.4 0.0 0.00068 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.6 EDK40526.2 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EDK40526.2 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EDK40526.2 - 0.0017 17.0 0.0 0.004 15.8 0.0 1.4 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase NodS PF05401.11 EDK40526.2 - 0.0025 17.5 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_2 PF00891.18 EDK40526.2 - 0.004 16.5 0.0 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain TehB PF03848.14 EDK40526.2 - 0.006 16.0 0.1 0.0086 15.5 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB DREV PF05219.12 EDK40526.2 - 0.0065 15.6 0.0 0.0099 15.0 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase HepII_C PF18675.1 EDK40526.2 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Heparinase II C-terminal domain UPF0020 PF01170.18 EDK40526.2 - 0.17 11.5 0.0 0.48 10.1 0.0 1.8 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Sulfatase PF00884.23 EDK40527.2 - 2.1e-40 139.0 0.0 2.8e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EDK40527.2 - 2e-08 34.2 0.0 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EDK40527.2 - 1.8e-07 31.4 0.5 3.5e-06 27.2 0.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 EDK40527.2 - 0.051 12.2 0.0 0.074 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) CBM64 PF18666.1 EDK40527.2 - 0.07 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate-binding module 64 Glyco_hydro81C PF17652.1 EDK40528.2 - 1.2e-145 485.2 7.4 1.5e-145 484.9 7.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EDK40528.2 - 1.5e-90 303.7 0.1 2.2e-90 303.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain INTAP PF16617.5 EDK40529.2 - 1.6 9.1 21.8 6.5 7.1 9.8 2.8 1 1 2 3 3 3 0 Intersectin and clathrin adaptor AP2 binding region OCRE PF17780.1 EDK40529.2 - 1.8 8.7 10.4 84 3.3 0.2 5.2 1 1 5 6 6 6 0 OCRE domain Arm PF00514.23 EDK40530.2 - 8.9e-86 279.6 15.6 1.1e-12 47.5 0.1 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EDK40530.2 - 4.6e-26 91.1 6.1 2.6e-25 88.7 6.1 2.3 2 0 0 2 2 2 1 Importin beta binding domain HEAT_EZ PF13513.6 EDK40530.2 - 5e-24 84.4 1.5 9.3e-06 26.0 0.1 5.6 4 1 1 5 5 5 5 HEAT-like repeat Arm_3 PF16186.5 EDK40530.2 - 1.5e-21 75.7 4.0 3.4e-21 74.5 4.0 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT PF02985.22 EDK40530.2 - 1.7e-14 52.7 0.2 0.026 14.8 0.0 6.9 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 EDK40530.2 - 4e-14 52.8 0.1 0.00025 21.4 0.0 5.0 1 1 3 5 5 5 2 HEAT repeats Adaptin_N PF01602.20 EDK40530.2 - 1.7e-06 26.9 0.0 0.0046 15.6 0.0 2.2 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 EDK40530.2 - 1.2e-05 25.3 0.0 0.31 11.1 0.0 4.3 3 1 2 5 5 5 2 V-ATPase subunit H RICTOR_V PF14668.6 EDK40530.2 - 1.5e-05 25.2 1.2 0.22 11.8 0.0 4.9 5 1 1 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 EDK40530.2 - 3.9e-05 23.2 0.1 0.25 10.8 0.0 4.2 2 1 2 4 4 4 1 Armadillo-like Atx10homo_assoc PF09759.9 EDK40530.2 - 0.0027 17.7 0.1 2.1 8.4 0.0 3.6 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Usp PF00582.26 EDK40532.2 - 2.1e-08 34.8 0.0 3.3e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family Far-17a_AIG1 PF04750.14 EDK40533.2 - 2.5e-18 66.1 11.8 2.7e-18 66.0 11.8 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Far-17a_AIG1 PF04750.14 EDK40534.2 - 2.3e-13 49.9 12.3 2.3e-13 49.9 12.3 1.5 1 1 1 2 2 2 1 FAR-17a/AIG1-like protein Peptidase_M14 PF00246.24 EDK40535.2 - 4.9e-68 230.0 0.1 6.8e-68 229.6 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EDK40535.2 - 0.009 16.4 0.1 0.027 14.8 0.1 1.8 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Tyr_Deacylase PF02580.16 EDK40536.2 - 1.2e-52 178.3 0.0 1.3e-52 178.1 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase SEN1_N PF12726.7 EDK40536.2 - 0.071 11.3 0.0 0.076 11.2 0.0 1.0 1 0 0 1 1 1 0 SEN1 N terminal Aa_trans PF01490.18 EDK40537.1 - 6.2e-32 110.8 31.4 7.9e-32 110.5 31.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein F-box-like PF12937.7 EDK40539.2 - 0.0056 16.6 0.1 0.02 14.8 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDK40539.2 - 0.0056 16.5 0.2 0.017 15.0 0.2 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EDK40539.2 - 1.3 9.6 10.6 25 5.5 0.1 5.6 6 2 0 6 6 6 0 Leucine Rich repeats (2 copies) Pga1 PF10333.9 EDK40540.2 - 1.2e-29 103.4 0.4 1.5e-29 103.1 0.4 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Endosulfine PF04667.17 EDK40541.2 - 3.2e-31 107.3 1.3 4.6e-31 106.8 1.3 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Autophagy_act_C PF03987.15 EDK40542.2 - 1.9e-13 50.8 0.6 3.9e-13 49.8 0.6 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain INSIG PF07281.12 EDK40544.2 - 4.6e-30 104.8 3.8 7.4e-30 104.2 3.8 1.3 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) WLM PF08325.10 EDK40545.2 - 4.8e-56 189.9 0.0 6.6e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 EDK40545.2 - 0.077 13.0 0.0 0.18 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF45 TMP-TENI PF02581.17 EDK40546.2 - 6.3e-54 182.0 0.8 9.7e-54 181.4 0.8 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase HK PF02110.15 EDK40546.2 - 5.3e-40 137.3 0.1 1.3e-39 136.0 0.1 1.6 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Flu_M1_C PF08289.11 EDK40546.2 - 0.099 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain RNase_P_Rpp14 PF01900.19 EDK40547.2 - 5e-35 119.8 0.0 6.5e-35 119.5 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family TPR_19 PF14559.6 EDK40548.2 - 6.7e-23 81.0 4.5 3.3e-09 37.1 0.3 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDK40548.2 - 9.8e-17 59.7 16.1 0.0054 16.8 0.0 9.0 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EDK40548.2 - 7.4e-16 58.2 14.9 2.4e-06 27.7 0.0 7.0 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDK40548.2 - 4e-15 54.9 8.4 0.0014 18.4 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK40548.2 - 1.5e-14 54.0 7.7 2.9e-08 33.8 0.1 5.0 6 0 0 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDK40548.2 - 4.6e-14 51.9 5.2 0.00076 20.1 0.1 8.3 6 2 4 10 10 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDK40548.2 - 6.5e-14 50.9 19.6 0.00086 19.3 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDK40548.2 - 6.6e-14 52.3 3.9 9.2e-06 26.2 0.1 6.5 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDK40548.2 - 6.5e-13 48.4 4.5 0.29 11.9 0.0 7.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDK40548.2 - 6.8e-09 35.3 2.5 3.8e-05 23.3 0.3 4.9 5 0 0 5 5 5 1 TPR repeat TPR_7 PF13176.6 EDK40548.2 - 3e-08 33.1 1.7 0.41 10.8 0.0 5.8 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 EDK40548.2 - 1.8e-07 31.4 4.1 0.00075 19.8 0.2 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK40548.2 - 1.1e-06 28.6 6.8 0.36 11.3 0.1 7.2 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK40548.2 - 2.9e-06 26.7 7.0 0.014 14.6 0.1 4.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDK40548.2 - 1.7e-05 24.5 9.9 1.2 9.0 0.0 5.5 7 0 0 7 7 5 3 Tetratricopeptide repeat RPN7 PF10602.9 EDK40548.2 - 5.3e-05 23.0 2.6 0.45 10.2 0.1 4.6 3 1 0 3 3 3 1 26S proteasome subunit RPN7 TPR_9 PF13371.6 EDK40548.2 - 0.0001 22.4 4.8 0.72 10.0 0.1 4.6 3 2 1 5 5 5 3 Tetratricopeptide repeat RPN6_N PF18055.1 EDK40548.2 - 0.0099 16.2 3.2 7.3 7.0 0.3 4.6 4 1 1 5 5 5 0 26S proteasome regulatory subunit RPN6 N-terminal domain Alkyl_sulf_dimr PF14863.6 EDK40548.2 - 0.01 16.3 0.0 0.037 14.5 0.0 1.9 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_3 PF07720.12 EDK40548.2 - 0.031 14.3 0.0 12 6.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EDK40548.2 - 0.033 14.6 0.3 0.95 9.9 0.0 3.1 3 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_5 PF12688.7 EDK40548.2 - 0.033 14.4 2.9 0.056 13.7 0.1 2.8 5 0 0 5 5 2 0 Tetratrico peptide repeat NARP1 PF12569.8 EDK40548.2 - 0.062 12.2 13.6 1.4 7.7 0.0 4.2 3 1 1 4 4 4 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EDK40548.2 - 0.065 13.9 0.8 0.065 13.9 0.8 2.9 3 0 0 3 3 1 0 Tetratricopeptide repeat Clathrin PF00637.20 EDK40548.2 - 0.082 12.8 2.9 0.78 9.6 0.0 3.6 4 0 0 4 4 4 0 Region in Clathrin and VPS RasGEF_N PF00618.20 EDK40548.2 - 1 9.7 0.0 1 9.7 0.0 2.8 4 0 0 4 4 2 0 RasGEF N-terminal motif Glyco_transf_24 PF18404.1 EDK40549.2 - 5.7e-131 435.8 2.1 9.6e-131 435.1 0.8 1.9 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EDK40549.2 - 1.2e-33 117.1 5.8 3.5e-30 105.8 0.3 4.5 4 1 1 5 5 5 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EDK40549.2 - 4.1e-33 114.8 0.2 1.1e-32 113.5 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EDK40549.2 - 1.1e-14 54.5 0.0 3.3e-14 52.9 0.0 1.9 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 EDK40549.2 - 8e-10 38.8 1.9 2.5e-09 37.2 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EDK40549.2 - 4.5e-09 36.5 2.4 2.6e-07 30.8 0.3 3.8 4 0 0 4 4 4 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 EDK40549.2 - 6.4e-08 32.5 0.0 1.8e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 8 TerD PF02342.18 EDK40549.2 - 0.061 12.8 0.1 0.24 10.8 0.1 2.0 2 0 0 2 2 2 0 TerD domain MTHFR PF02219.17 EDK40550.2 - 7e-06 25.6 0.3 1e-05 25.0 0.3 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase TLD PF07534.16 EDK40552.2 - 6.5e-28 97.7 0.4 1.2e-24 87.1 0.2 2.1 1 1 1 2 2 2 2 TLD Asp_Glu_race PF01177.22 EDK40553.2 - 9.3e-10 38.7 0.0 1.5e-09 38.0 0.0 1.3 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase RBB1NT PF08169.11 EDK40553.2 - 0.035 14.2 0.1 0.16 12.1 0.0 2.1 2 1 0 2 2 2 0 RBB1NT (NUC162) domain Rad9 PF04139.13 EDK40554.2 - 9.6e-14 51.4 0.6 2.8e-13 49.9 0.6 1.7 1 1 0 1 1 1 1 Rad9 ESPR PF13018.6 EDK40554.2 - 0.083 12.7 0.1 0.28 11.0 0.1 2.0 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system MPC PF03650.13 EDK40555.1 - 4.3e-37 126.6 0.0 5e-37 126.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Zn_clus PF00172.18 EDK40556.2 - 1.9e-07 31.1 14.9 3.9e-07 30.1 14.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YabA PF06156.13 EDK40556.2 - 0.23 12.1 0.1 0.23 12.1 0.1 2.9 3 0 0 3 3 3 0 Initiation control protein YabA RAP1 PF07218.11 EDK40557.1 - 1.2 7.4 3.9 1.5 7.0 3.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2537 PF10801.8 EDK40558.2 - 0.84 9.9 6.2 0.44 10.8 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2537) DJ-1_PfpI PF01965.24 EDK40559.2 - 8.5e-09 35.4 0.0 2.8e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EDK40559.2 - 0.00035 20.3 0.3 0.0028 17.4 0.3 2.2 1 1 0 1 1 1 1 ThiJ/PfpI family-like Acyltransferase PF01553.21 EDK40560.1 - 6.1e-31 106.8 0.0 8.8e-31 106.3 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Adaptin_N PF01602.20 EDK40561.2 - 2.7e-91 306.7 15.2 5.6e-91 305.7 14.0 2.0 2 1 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EDK40561.2 - 3.5e-14 53.2 2.0 7.5e-14 52.1 1.1 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 L27 PF02828.16 EDK40561.2 - 0.07 12.9 0.1 0.26 11.1 0.1 2.0 1 0 0 1 1 1 0 L27 domain FLYWCH_u PF16662.5 EDK40561.2 - 1.2 9.2 3.2 5 7.3 0.2 2.4 2 0 0 2 2 2 0 FLYWCH-type zinc finger-containing protein 1 KxDL PF10241.9 EDK40562.2 - 3.9e-09 36.7 1.1 7.5e-09 35.7 1.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein FAM76 PF16046.5 EDK40562.2 - 0.033 13.6 1.2 0.04 13.3 1.2 1.1 1 0 0 1 1 1 0 FAM76 protein Ly49 PF08391.10 EDK40562.2 - 0.051 13.9 1.6 0.091 13.1 1.6 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Metallopep PF12044.8 EDK40563.2 - 4e-150 500.2 0.0 4.7e-150 499.9 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EDK40563.2 - 1.4e-05 25.1 0.0 3.5e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_3 PF13582.6 EDK40563.2 - 0.00057 20.4 0.4 0.0015 19.1 0.4 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EDK40563.2 - 0.011 14.7 0.2 0.029 13.3 0.3 1.6 2 0 0 2 2 2 0 Peptidase M66 Reprolysin_5 PF13688.6 EDK40563.2 - 0.012 15.8 0.5 0.022 14.9 0.5 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EDK40563.2 - 0.069 13.0 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF2576 PF10845.8 EDK40563.2 - 0.4 10.3 3.9 1.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) Tyr-DNA_phospho PF06087.12 EDK40564.2 - 4.5e-118 394.8 0.4 5.7e-118 394.5 0.4 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EDK40564.2 - 0.043 13.7 0.2 0.67 9.8 0.1 2.4 2 0 0 2 2 2 0 PLD-like domain SMC_N PF02463.19 EDK40565.2 - 8.1e-54 182.4 54.9 1.5e-52 178.2 54.9 3.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDK40565.2 - 6.6e-27 94.1 0.1 3.2e-26 91.9 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDK40565.2 - 3e-16 60.1 11.6 1.3e-10 41.6 0.7 3.7 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDK40565.2 - 6.4e-15 56.2 11.6 6.4e-15 56.2 11.6 7.4 3 2 5 8 8 8 1 AAA domain AAA_15 PF13175.6 EDK40565.2 - 2.5e-11 43.9 9.1 2.5e-11 43.9 9.1 4.2 2 2 1 4 4 4 2 AAA ATPase domain AAA_13 PF13166.6 EDK40565.2 - 0.00091 18.0 18.3 0.00091 18.0 18.3 5.9 3 2 3 6 6 6 3 AAA domain AAA_29 PF13555.6 EDK40565.2 - 0.014 15.1 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain BRCT_2 PF16589.5 EDK40565.2 - 0.057 13.8 0.1 5.2 7.6 0.0 3.1 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain FtsK_SpoIIIE PF01580.18 EDK40565.2 - 0.065 12.6 0.0 0.065 12.6 0.0 3.3 3 1 0 3 3 3 0 FtsK/SpoIIIE family Trimer_CC PF08954.11 EDK40565.2 - 1.4 8.5 15.8 0.55 9.8 0.4 4.9 5 0 0 5 5 5 0 Trimerisation motif EF-hand_1 PF00036.32 EDK40567.1 - 2.1e-28 95.7 3.8 9.5e-09 34.2 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EDK40567.1 - 1.1e-24 86.7 0.8 6.4e-16 58.6 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDK40567.1 - 2e-23 82.0 3.2 8.2e-10 38.4 0.2 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EDK40567.1 - 2.6e-22 77.3 3.6 4.8e-08 32.1 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EDK40567.1 - 5.2e-18 63.4 2.9 1.7e-08 33.7 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_9 PF14658.6 EDK40567.1 - 2.3e-09 37.4 0.2 0.00021 21.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EDK40567.1 - 5.6e-07 29.9 0.1 8.9e-05 22.8 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EDK40567.1 - 6.1e-07 29.4 1.7 0.0044 17.0 0.2 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EDK40567.1 - 1e-06 28.8 5.4 0.0016 18.6 1.2 3.0 1 1 2 3 3 3 3 Dockerin type I domain UPF0154 PF03672.13 EDK40567.1 - 1.4e-05 25.0 0.0 0.23 11.5 0.0 2.8 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) TerB PF05099.13 EDK40567.1 - 0.00017 21.6 0.4 0.003 17.5 0.1 2.0 1 1 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_11 PF08976.11 EDK40567.1 - 0.00017 22.4 0.0 0.045 14.6 0.0 2.0 1 1 1 2 2 2 2 EF-hand domain Poly_export PF02563.16 EDK40567.1 - 0.0039 17.4 0.0 0.016 15.4 0.0 1.9 1 1 1 2 2 2 1 Polysaccharide biosynthesis/export protein EF-hand_10 PF14788.6 EDK40567.1 - 0.0092 15.8 0.7 0.02 14.7 0.0 1.9 2 1 0 2 2 2 1 EF hand DUF5580 PF17743.1 EDK40567.1 - 0.044 12.3 0.0 0.046 12.3 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Spore_III_AB PF09548.10 EDK40567.1 - 0.067 13.3 0.0 0.088 12.9 0.0 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) EF-hand_14 PF17959.1 EDK40567.1 - 0.091 13.1 0.2 0.27 11.6 0.0 1.9 2 1 0 2 2 2 0 EF-hand domain IMS PF00817.20 EDK40568.2 - 4.3e-36 124.2 0.0 3.5e-35 121.2 0.0 2.3 2 0 0 2 2 2 1 impB/mucB/samB family BRCT_2 PF16589.5 EDK40568.2 - 3e-11 43.6 0.0 1e-10 41.9 0.0 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 EDK40568.2 - 1.5e-10 41.8 0.0 4.9e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 EDK40568.2 - 3.2e-05 24.2 0.1 0.0001 22.6 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain REV1_C PF16727.5 EDK40568.2 - 5.7e-05 23.4 0.0 0.00017 21.9 0.0 1.8 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain LIG3_BRCT PF16759.5 EDK40568.2 - 9.4e-05 22.6 0.0 0.00025 21.2 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain UBM PF14377.6 EDK40568.2 - 0.00021 20.6 1.2 0.6 9.6 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin binding region IMS_HHH PF11798.8 EDK40568.2 - 0.00025 21.2 0.0 0.0056 16.9 0.0 3.0 3 0 0 3 3 3 1 IMS family HHH motif TFB6 PF17110.5 EDK40568.2 - 7.8 6.2 9.5 38 4.0 7.6 2.8 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH Hist_deacetyl PF00850.19 EDK40569.2 - 9.1e-77 258.5 0.0 1.3e-76 258.0 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Glycos_transf_1 PF00534.20 EDK40570.2 - 5e-15 55.5 0.0 7.3e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDK40570.2 - 2.1e-10 41.2 0.0 4.6e-10 40.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDK40570.2 - 0.0017 18.4 0.0 0.0031 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EDK40570.2 - 0.018 15.5 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 XFP_C PF09363.10 EDK40570.2 - 0.059 12.8 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 XFP C-terminal domain XPA_C PF05181.12 EDK40571.2 - 1.1e-20 73.3 0.1 2.4e-20 72.2 0.1 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EDK40571.2 - 8.8e-05 22.5 0.4 8.8e-05 22.5 0.4 2.3 3 0 0 3 3 3 1 XPA protein N-terminal FYVE_2 PF02318.16 EDK40571.2 - 0.29 11.4 13.8 0.46 10.7 1.3 3.5 3 0 0 3 3 3 0 FYVE-type zinc finger HSP90 PF00183.18 EDK40572.1 - 1.4e-223 743.5 32.5 1.8e-223 743.2 32.5 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EDK40572.1 - 7e-15 55.5 0.0 1.4e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDK40572.1 - 1.3e-09 38.0 0.0 4.7e-09 36.2 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EDK40572.1 - 0.075 13.0 0.3 0.26 11.3 0.3 1.9 1 0 0 1 1 1 0 Tumour suppressor protein Ubiq-assoc PF09145.10 EDK40572.1 - 0.13 12.3 0.8 2.7 8.0 0.0 2.9 3 0 0 3 3 3 0 Ubiquitin-associated Cofac_haem_bdg PF04187.13 EDK40572.1 - 0.13 12.3 0.6 0.32 11.0 0.1 1.9 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN RTP1_C1 PF10363.9 EDK40573.2 - 1.2e-34 118.9 0.1 1.2e-33 115.7 0.1 2.8 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EDK40573.2 - 0.00039 20.5 1.1 0.04 14.0 0.0 3.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RTP1_C2 PF10304.9 EDK40573.2 - 0.00044 19.9 0.0 0.0015 18.2 0.0 1.9 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Telomere_reg-2 PF10193.9 EDK40573.2 - 0.047 14.1 0.7 11 6.5 0.3 3.4 3 1 0 3 3 3 0 Telomere length regulation protein RIX1 PF08167.12 EDK40573.2 - 0.066 13.0 0.8 7.1 6.3 0.0 2.8 2 1 0 2 2 2 0 rRNA processing/ribosome biogenesis Ank_2 PF12796.7 EDK40574.2 - 2.1e-26 92.3 0.6 2.1e-15 57.0 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK40574.2 - 1.9e-16 60.2 0.0 4.7e-12 46.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK40574.2 - 6.2e-16 58.3 0.1 8.5e-09 35.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDK40574.2 - 1.4e-13 49.6 0.1 2.9e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EDK40574.2 - 2.9e-11 43.3 0.1 1e-06 28.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat eIF-5_eIF-2B PF01873.17 EDK40575.2 - 6.8e-39 132.4 0.1 1.1e-38 131.7 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.15 EDK40575.2 - 0.023 14.5 0.0 0.09 12.6 0.0 2.0 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.12 EDK40575.2 - 0.1 12.1 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding GET2 PF08690.10 EDK40575.2 - 0.14 11.8 6.5 0.35 10.5 6.4 1.7 1 1 0 1 1 1 0 GET complex subunit GET2 DUF2752 PF10825.8 EDK40575.2 - 0.15 12.1 0.1 0.27 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) zf-HYPF PF07503.12 EDK40575.2 - 0.17 11.7 0.1 24 4.8 0.0 2.8 2 0 0 2 2 2 0 HypF finger MADF_DNA_bdg PF10545.9 EDK40576.2 - 0.11 12.8 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pkinase PF00069.25 EDK40577.2 - 2.5e-37 128.7 0.0 3.2e-27 95.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40577.2 - 5.1e-15 55.4 0.0 2.8e-12 46.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Meleagrin PF08189.11 EDK40577.2 - 0.13 11.9 3.3 0.26 11.0 1.1 2.3 2 0 0 2 2 2 0 Meleagrin/Cygnin family Rhomboid PF01694.22 EDK40578.2 - 3.6e-12 46.5 5.4 3.6e-12 46.5 5.4 1.8 1 1 1 2 2 2 1 Rhomboid family Inp1 PF12634.7 EDK40579.2 - 5.6e-16 58.8 4.1 6.2e-16 58.7 0.2 3.0 2 1 0 2 2 2 1 Inheritance of peroxisomes protein 1 Porin_3 PF01459.22 EDK40580.2 - 6.7e-88 294.6 0.5 8e-88 294.4 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic porin PFK PF00365.20 EDK40581.2 - 9.4e-182 602.6 7.0 2.4e-104 348.7 3.2 2.2 2 0 0 2 2 2 2 Phosphofructokinase Glyoxalase PF00903.25 EDK40581.2 - 0.0012 19.0 0.0 0.0062 16.7 0.0 2.1 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DAGK_cat PF00781.24 EDK40581.2 - 0.014 15.0 0.1 0.041 13.5 0.1 1.8 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain UVR PF02151.19 EDK40581.2 - 0.13 12.0 1.1 0.35 10.7 1.1 1.7 1 0 0 1 1 1 0 UvrB/uvrC motif TBCC PF07986.12 EDK40582.1 - 1.4e-12 47.4 0.9 2.5e-12 46.6 0.9 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C HMG_box PF00505.19 EDK40582.1 - 0.1 13.0 0.1 1.2 9.6 0.0 2.5 3 0 0 3 3 3 0 HMG (high mobility group) box TPP_enzyme_N PF02776.18 EDK40583.2 - 2.8e-18 66.1 0.0 5e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDK40583.2 - 3.7e-16 59.3 0.0 8.4e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDK40583.2 - 5.7e-05 22.9 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DAO PF01266.24 EDK40584.2 - 3.5e-22 79.5 0.0 4.2e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fungal_trans_2 PF11951.8 EDK40585.2 - 5.1e-47 160.5 0.0 6e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain STAS PF01740.21 EDK40585.2 - 0.12 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 STAS domain AA_permease PF00324.21 EDK40586.2 - 4.5e-90 302.5 50.0 5.4e-90 302.3 50.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40586.2 - 6.1e-22 78.0 51.4 8e-22 77.6 51.4 1.1 1 0 0 1 1 1 1 Amino acid permease Peptidase_M19 PF01244.21 EDK40587.2 - 7.7e-108 360.4 0.0 9.2e-108 360.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 EDK40587.2 - 0.013 15.2 0.0 0.026 14.3 0.0 1.4 1 1 0 1 1 1 0 Amidohydrolase AMP-binding PF00501.28 EDK40588.2 - 1.9e-63 214.5 0.0 1.4e-61 208.4 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme TIP49 PF06068.13 EDK40589.1 - 5.8e-146 486.2 2.2 7.2e-146 485.9 2.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDK40589.1 - 1.3e-21 76.5 1.0 4.9e-21 74.6 0.8 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EDK40589.1 - 1.7e-08 35.0 2.3 2.2e-05 24.9 0.1 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDK40589.1 - 2.8e-06 27.2 2.0 0.0072 16.1 0.1 2.8 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EDK40589.1 - 0.00043 20.6 0.2 0.0019 18.5 0.2 2.0 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EDK40589.1 - 0.00066 19.1 0.2 0.0012 18.3 0.2 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EDK40589.1 - 0.00084 19.8 1.8 0.0015 18.9 0.4 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK40589.1 - 0.0037 17.5 0.1 0.34 11.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDK40589.1 - 0.0047 16.3 0.8 0.091 12.1 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDK40589.1 - 0.013 15.5 0.1 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EDK40589.1 - 0.022 15.0 0.1 0.14 12.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDK40589.1 - 0.048 13.2 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EDK40589.1 - 0.064 13.0 0.0 7.8 6.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EDK40589.1 - 0.16 11.5 0.3 0.66 9.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region Hydin_ADK PF17213.3 EDK40589.1 - 0.61 10.3 2.5 0.52 10.6 0.1 2.0 2 2 0 2 2 2 0 Hydin Adenylate kinase-like domain ATP-synt_C PF00137.21 EDK40590.2 - 6.8e-30 103.2 29.9 6.7e-19 68.0 9.4 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mis14 PF08641.12 EDK40591.2 - 2e-26 92.9 0.7 3.2e-26 92.2 0.7 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like TMF_TATA_bd PF12325.8 EDK40591.2 - 0.019 15.2 1.6 1.5 9.0 0.1 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding RasGAP_C PF03836.15 EDK40592.2 - 7.3e-40 136.3 7.1 7.3e-40 136.3 7.1 2.4 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.19 EDK40592.2 - 1.5e-39 135.9 0.1 4e-39 134.5 0.1 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EDK40592.2 - 3.9e-11 43.1 2.8 8.5e-11 42.0 0.0 2.9 3 0 0 3 3 3 1 Calponin homology (CH) domain IQ PF00612.27 EDK40592.2 - 1.5e-06 27.5 16.8 0.12 12.2 0.1 9.1 10 0 0 10 10 10 1 IQ calmodulin-binding motif DivIC PF04977.15 EDK40592.2 - 1 9.1 5.7 0.67 9.8 0.5 2.8 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.8 EDK40592.2 - 4.2 7.4 13.1 1 9.4 2.5 3.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding WD40_4 PF16300.5 EDK40593.2 - 7.1e-20 70.6 0.1 1.5e-19 69.6 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EDK40593.2 - 0.015 16.1 0.7 12 7.0 0.1 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat TRAF_BIRC3_bd PF16673.5 EDK40593.2 - 0.043 13.6 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Prefoldin PF02996.17 EDK40593.2 - 0.065 13.1 0.7 0.065 13.1 0.7 1.9 2 0 0 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 EDK40593.2 - 0.14 12.3 1.7 0.16 12.1 0.1 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 EDK40593.2 - 3.3 8.0 6.1 0.6 10.3 1.9 1.9 2 0 0 2 2 2 0 Haemolysin XhlA LCAT PF02450.15 EDK40594.2 - 2.1e-115 386.1 0.0 3.2e-115 385.5 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LIDHydrolase PF10230.9 EDK40594.2 - 0.083 12.4 0.1 0.38 10.3 0.0 2.1 2 1 1 3 3 3 0 Lipid-droplet associated hydrolase DUF1749 PF08538.10 EDK40594.2 - 0.084 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EDK40594.2 - 0.14 12.7 0.0 0.35 11.4 0.0 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK40594.2 - 0.17 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Autophagy_N PF03986.13 EDK40595.2 - 3.6e-46 156.5 0.3 5.9e-46 155.8 0.3 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EDK40595.2 - 1.1e-14 54.8 0.1 2.5e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EDK40595.2 - 1.1e-14 53.6 0.4 2.7e-14 52.4 0.4 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Par3_HAL_N_term PF12053.8 EDK40595.2 - 0.67 10.2 3.2 0.79 10.0 0.0 2.6 2 1 1 3 3 3 0 N-terminal of Par3 and HAL proteins Whi5 PF08528.11 EDK40596.2 - 0.039 13.6 6.7 0.039 13.6 6.7 2.3 2 0 0 2 2 2 0 Whi5 like TAF1D PF15333.6 EDK40596.2 - 0.4 10.4 3.6 0.66 9.7 3.6 1.3 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D PCI PF01399.27 EDK40597.2 - 3.1e-07 30.9 0.0 5.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 PCI domain ERG2_Sigma1R PF04622.12 EDK40598.2 - 8e-93 309.6 0.5 9.6e-93 309.3 0.5 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Wzz PF02706.15 EDK40598.2 - 0.089 13.1 0.1 0.6 10.4 0.0 2.0 2 0 0 2 2 2 0 Chain length determinant protein MatE PF01554.18 EDK40599.2 - 2.2e-57 193.2 36.1 7.1e-35 120.0 10.1 2.7 3 0 0 3 3 3 2 MatE CcmH PF03918.14 EDK40599.2 - 0.46 9.8 1.6 0.54 9.5 0.1 1.9 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Cyclin_N PF00134.23 EDK40600.2 - 7.9e-29 100.0 0.0 1.7e-28 98.9 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Rot1 PF10681.9 EDK40601.2 - 1.4e-94 315.4 1.6 1.7e-94 315.2 1.6 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VHS PF00790.19 EDK40603.2 - 4.2e-26 91.5 0.1 1.2e-25 90.0 0.0 1.8 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EDK40603.2 - 2.6e-18 65.9 4.8 4.6e-18 65.1 4.8 1.4 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EDK40603.2 - 1.4e-06 27.8 8.0 0.00019 21.1 1.8 2.5 2 0 0 2 2 2 2 Ubiquitin interaction motif GAT PF03127.14 EDK40603.2 - 0.056 13.8 0.7 0.13 12.6 0.7 1.6 1 0 0 1 1 1 0 GAT domain OAD_gamma PF04277.13 EDK40603.2 - 0.085 13.5 1.1 0.26 11.9 0.1 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain zf-AN1 PF01428.16 EDK40603.2 - 0.4 10.9 7.5 0.83 9.9 7.5 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger zf-RING_2 PF13639.6 EDK40603.2 - 3.8 7.9 9.5 0.71 10.3 5.2 1.9 2 0 0 2 2 2 0 Ring finger domain Orn_Arg_deC_N PF02784.16 EDK40604.2 - 4.4e-73 245.7 0.0 5.5e-73 245.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EDK40604.2 - 2.9e-17 62.7 0.0 4.1e-17 62.2 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 EDK40604.2 - 0.0054 16.4 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Metallophos PF00149.28 EDK40605.2 - 2.5e-32 113.0 0.0 4.5e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Voldacs PF03517.13 EDK40606.2 - 8.9e-24 84.2 0.4 1.7e-23 83.3 0.4 1.5 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Hid1 PF12722.7 EDK40607.2 - 3.7e-133 445.5 20.0 1.1e-131 440.5 20.0 2.4 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EDK40607.2 - 3.5e-28 98.4 8.7 6.2e-28 97.6 8.7 1.3 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein WGG PF10273.9 EDK40608.1 - 6.8e-23 81.1 1.1 1.6e-22 80.0 1.1 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 AAA PF00004.29 EDK40609.2 - 4e-18 66.1 0.0 8.6e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EDK40609.2 - 1.8e-13 50.4 0.7 6.1e-13 48.7 0.5 2.0 1 1 0 1 1 1 1 AAA lid domain AAA_16 PF13191.6 EDK40609.2 - 1.6e-09 38.3 0.2 1.1e-07 32.5 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK40609.2 - 3.3e-06 27.4 0.0 8.8e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain BAH PF01426.18 EDK40609.2 - 1.8e-05 24.6 0.4 9.5e-05 22.2 0.1 2.2 2 0 0 2 2 2 1 BAH domain Cdc6_C PF09079.11 EDK40609.2 - 0.00035 20.5 0.0 0.0059 16.6 0.1 2.5 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain ATPase_2 PF01637.18 EDK40609.2 - 0.0012 18.9 0.1 0.0012 18.9 0.1 3.2 4 1 0 4 4 4 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EDK40609.2 - 0.0023 18.3 0.6 0.0076 16.6 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDK40609.2 - 0.024 14.4 4.9 0.042 13.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EDK40609.2 - 0.07 13.7 0.0 0.22 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EDK40609.2 - 0.084 12.8 0.1 0.22 11.4 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_6 PF12774.7 EDK40609.2 - 0.085 11.8 0.3 2.1 7.2 0.0 2.2 1 1 1 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Ras PF00071.22 EDK40610.2 - 7.2e-27 94.0 1.0 8.2e-27 93.8 1.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40610.2 - 1.2e-17 64.3 0.1 1.8e-17 63.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EDK40610.2 - 2.9e-05 23.5 0.6 3.6e-05 23.2 0.6 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EDK40610.2 - 0.00011 21.7 0.1 0.00013 21.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK40610.2 - 0.02 14.5 0.1 0.026 14.0 0.1 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Ribosomal_S3Ae PF01015.18 EDK40611.1 - 3.6e-87 291.1 4.5 4.4e-87 290.9 4.5 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Phage_TAC_5 PF08890.11 EDK40611.1 - 0.044 13.8 1.7 3.6 7.6 0.0 2.5 2 1 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC DUF2369 PF10179.9 EDK40611.1 - 0.052 13.9 0.4 0.13 12.7 0.4 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Anoctamin PF04547.12 EDK40611.1 - 0.08 11.8 0.1 0.094 11.5 0.1 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel SpoVIF PF14069.6 EDK40611.1 - 0.65 9.8 5.0 5.8 6.8 1.5 2.6 2 0 0 2 2 2 0 Stage VI sporulation protein F C2 PF00168.30 EDK40612.2 - 3.9e-66 219.8 0.5 1.4e-19 70.3 0.0 5.5 5 0 0 5 5 5 5 C2 domain Nop14 PF04147.12 EDK40612.2 - 0.63 8.2 18.2 1.4 7.0 18.2 1.5 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EDK40612.2 - 2.9 6.1 14.6 5.3 5.2 14.6 1.3 1 0 0 1 1 1 0 CDC45-like protein FKBP_C PF00254.28 EDK40613.1 - 3.4e-27 94.6 0.0 1.1e-26 93.0 0.0 1.9 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EDK40613.1 - 5.6e-23 81.5 5.2 5.6e-23 81.5 5.2 2.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain SDA1 PF05285.12 EDK40613.1 - 2.5 7.4 81.3 3.4 7.0 37.2 2.1 2 0 0 2 2 2 0 SDA1 HMG-CoA_red PF00368.18 EDK40614.2 - 8.5e-143 475.8 1.5 1.2e-142 475.3 1.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EDK40614.2 - 4.2e-10 39.7 0.5 5.3e-09 36.1 0.5 2.5 1 1 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EDK40614.2 - 1.4e-08 34.7 10.3 2.9e-08 33.7 10.3 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Cys_Met_Meta_PP PF01053.20 EDK40615.2 - 1e-32 113.2 0.0 1.4e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDK40615.2 - 0.0012 18.2 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cyt-b5 PF00173.28 EDK40616.1 - 1.7e-11 44.1 0.1 2.4e-11 43.6 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Whi5 PF08528.11 EDK40616.1 - 0.039 13.6 0.0 0.075 12.7 0.0 1.5 1 0 0 1 1 1 0 Whi5 like Zn_clus PF00172.18 EDK40617.2 - 0.015 15.4 11.0 0.026 14.6 11.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain SlyX PF04102.12 EDK40617.2 - 0.068 13.8 1.1 0.73 10.5 0.1 3.0 2 0 0 2 2 2 0 SlyX Glyco_hydro_47 PF01532.20 EDK40618.2 - 1.6e-166 554.7 0.0 1.9e-166 554.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 bZIP_1 PF00170.21 EDK40619.2 - 3.3e-07 30.3 3.4 7.9e-07 29.1 3.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor Aft1_HRA PF11786.8 EDK40619.2 - 7.6e-05 23.0 0.5 7.6e-05 23.0 0.5 3.8 3 2 2 5 5 5 1 Aft1 HRA domain bZIP_2 PF07716.15 EDK40619.2 - 0.0013 18.8 4.2 0.0013 18.8 4.2 2.1 2 1 0 2 2 2 1 Basic region leucine zipper Leptin PF02024.15 EDK40619.2 - 0.0017 18.1 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 Leptin Stathmin PF00836.19 EDK40619.2 - 0.14 12.2 12.4 0.26 11.3 12.4 1.4 1 0 0 1 1 1 0 Stathmin family DUF3492 PF11997.8 EDK40619.2 - 0.95 9.1 2.8 1.5 8.5 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) DUF1708 PF08101.11 EDK40620.2 - 5.3e-127 424.6 5.4 8e-126 420.7 5.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) Carn_acyltransf PF00755.20 EDK40623.2 - 7.1e-133 444.3 0.6 8.4e-133 444.1 0.6 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase G_glu_transpept PF01019.21 EDK40624.2 - 1.2e-87 294.9 0.0 1.5e-87 294.6 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Bul1_N PF04425.12 EDK40625.2 - 2.8e-102 342.8 1.5 4.3e-91 305.9 0.2 2.3 1 1 1 2 2 2 2 Bul1 N terminus Bul1_C PF04426.12 EDK40625.2 - 6.9e-16 58.5 8.6 4.8e-14 52.4 1.3 4.0 2 1 1 3 3 3 1 Bul1 C terminus Bul1_N PF04425.12 EDK40626.2 - 4.3e-93 312.5 12.1 3e-92 309.8 9.1 3.3 1 1 1 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 EDK40626.2 - 4.8e-47 160.7 7.7 4.8e-47 160.7 7.7 2.9 3 0 0 3 3 3 1 Bul1 C terminus TPR_2 PF07719.17 EDK40627.2 - 9.6e-09 34.7 7.4 0.023 14.8 0.7 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDK40627.2 - 2.4e-08 33.5 13.2 0.00022 20.9 1.9 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDK40627.2 - 0.0082 16.3 8.7 7.4 7.1 0.4 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDK40627.2 - 0.024 14.7 6.0 0.091 12.8 0.1 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Pox_T4_N PF04491.12 EDK40627.2 - 0.036 13.9 0.2 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus TPR_12 PF13424.6 EDK40627.2 - 0.037 14.3 2.2 0.27 11.5 0.9 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat INCENP_ARK-bind PF03941.15 EDK40628.2 - 1.9e-12 46.9 0.1 5.5e-12 45.5 0.1 1.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Bul1_N PF04425.12 EDK40629.2 - 9.5e-82 275.1 4.9 6e-74 249.4 0.1 2.8 1 1 1 2 2 2 2 Bul1 N terminus Bul1_C PF04426.12 EDK40629.2 - 6e-19 68.5 10.1 1.9e-10 40.6 1.3 2.9 2 1 1 3 3 3 2 Bul1 C terminus PQ-loop PF04193.14 EDK40630.2 - 1.2e-22 79.4 9.4 3.7e-13 49.0 0.7 2.7 2 0 0 2 2 2 2 PQ loop repeat Hydrophob_seed PF14547.6 EDK40630.2 - 0.046 13.9 0.9 0.11 12.8 0.4 1.8 1 1 0 1 1 1 0 Hydrophobic seed protein GTP_EFTU PF00009.27 EDK40631.1 - 4.2e-59 199.4 0.3 5.7e-59 198.9 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDK40631.1 - 1.4e-26 93.0 0.0 3e-26 91.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDK40631.1 - 5.9e-21 74.6 2.2 1.1e-20 73.8 1.5 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK40631.1 - 2.8e-05 24.2 0.0 8.4e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK40631.1 - 0.015 15.2 0.0 0.037 13.9 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EDK40631.1 - 0.038 13.6 0.9 0.052 13.1 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EDK40631.1 - 0.062 13.1 0.6 13 5.5 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ANAPC1 PF12859.7 EDK40632.2 - 3.5e-10 40.5 3.9 2.2e-09 37.9 3.9 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EDK40632.2 - 3.7e-07 30.3 3.5 0.067 13.7 0.0 5.1 4 0 0 4 4 4 3 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.15 EDK40633.2 - 1e-74 250.4 0.0 9.9e-57 191.7 0.1 2.2 2 0 0 2 2 2 2 Phosphatidylserine decarboxylase NADH_oxidored PF08040.11 EDK40633.2 - 0.028 14.1 0.0 0.066 12.9 0.0 1.6 1 0 0 1 1 1 0 MNLL subunit Big_5 PF13205.6 EDK40633.2 - 0.11 13.3 0.6 0.27 11.9 0.6 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain UBA2_C PF16195.5 EDK40633.2 - 1.2 9.9 5.7 22 5.8 1.3 2.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Mob1_phocein PF03637.17 EDK40634.2 - 1.4e-67 227.0 1.7 1.8e-67 226.6 1.7 1.1 1 0 0 1 1 1 1 Mob1/phocein family Ofd1_CTDD PF10637.9 EDK40634.2 - 0.065 12.6 0.3 0.11 11.8 0.3 1.3 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term MAGI_u1 PF16663.5 EDK40634.2 - 1.3 9.2 5.7 3.1 7.9 5.7 1.7 1 0 0 1 1 1 0 Unstructured region on MAGI RNA_pol PF00940.19 EDK40635.2 - 3.9e-178 592.5 0.2 1.1e-177 591.0 0.1 1.8 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EDK40635.2 - 1.1e-103 347.2 2.2 6.4e-103 344.7 1.7 2.2 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal FAD_SOX PF18371.1 EDK40635.2 - 0.042 14.2 0.0 0.46 10.9 0.0 2.8 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase PPR_long PF17177.4 EDK40635.2 - 0.048 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP PPR_2 PF13041.6 EDK40635.2 - 0.33 11.2 1.0 83 3.5 0.0 3.8 4 0 0 4 4 4 0 PPR repeat family Snf7 PF03357.21 EDK40636.2 - 6.1e-43 146.4 19.0 6.1e-43 146.4 19.0 1.8 1 1 1 2 2 2 1 Snf7 DUF4407 PF14362.6 EDK40636.2 - 0.029 13.7 15.9 0.03 13.7 9.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Hydantoinase_B PF02538.14 EDK40636.2 - 0.11 10.9 0.5 0.14 10.5 0.5 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase DASH_Dad4 PF08650.10 EDK40636.2 - 0.12 12.3 2.7 0.15 12.0 0.7 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad4 CCDC53 PF10152.9 EDK40636.2 - 2.9 8.3 12.3 4.2 7.8 11.5 1.7 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex TssO PF17561.2 EDK40636.2 - 3.1 7.9 13.4 1.8 8.7 0.8 2.8 2 1 1 3 3 3 0 Type VI secretion system, TssO NuA4 PF09340.10 EDK40636.2 - 4.3 7.3 7.5 0.33 10.9 0.2 2.7 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 DUF2730 PF10805.8 EDK40636.2 - 7.6 6.7 10.8 0.36 10.9 2.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) SNARE PF05739.19 EDK40637.2 - 5.8e-14 51.8 0.1 1.3e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 EDK40637.2 - 1.9e-05 23.7 0.5 0.00011 21.4 0.2 2.3 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain DUF16 PF01519.16 EDK40637.2 - 0.0014 19.1 7.9 0.0071 16.8 0.8 2.3 2 0 0 2 2 2 2 Protein of unknown function DUF16 Syntaxin PF00804.25 EDK40637.2 - 0.0019 17.9 6.3 0.012 15.3 0.5 2.5 2 0 0 2 2 2 2 Syntaxin Syntaxin-18_N PF10496.9 EDK40637.2 - 0.034 14.4 1.8 0.37 11.1 0.2 2.6 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Flagellin_C PF00700.21 EDK40637.2 - 0.068 13.5 2.5 2.9 8.3 0.2 2.6 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region FlaC_arch PF05377.11 EDK40637.2 - 0.42 11.1 5.7 0.49 10.8 0.3 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Tubulin PF00091.25 EDK40638.1 - 2.5e-48 164.9 0.0 3e-48 164.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EDK40638.1 - 0.0017 18.1 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDK40638.1 - 0.0059 15.8 0.0 0.0074 15.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin like TrmK PF04816.12 EDK40638.1 - 0.17 11.4 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Complex1_LYR PF05347.15 EDK40639.2 - 1.7e-10 40.7 0.8 3.4e-10 39.8 0.8 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDK40639.2 - 0.00017 22.2 1.0 0.00035 21.3 1.0 1.5 1 0 0 1 1 1 1 Complex1_LYR-like RIC1 PF07064.13 EDK40640.2 - 1.5e-29 103.2 0.9 3e-29 102.2 0.9 1.5 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EDK40640.2 - 0.079 13.3 0.0 4 7.8 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RCC1_2 PF13540.6 EDK40640.2 - 0.19 11.5 0.3 1.2 9.0 0.0 2.5 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Ribosomal_L13e PF01294.18 EDK40641.1 - 1.4e-69 233.5 6.9 2.1e-69 232.9 6.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_60s PF00428.19 EDK40642.1 - 1.6e-24 86.3 10.9 2e-24 86.0 10.9 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein LD_cluster3 PF18180.1 EDK40642.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.0 1 0 0 1 1 1 0 SLOG cluster3 family MFS_1 PF07690.16 EDK40643.2 - 1.4e-38 132.8 12.0 1.4e-38 132.8 12.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK40643.2 - 7.3e-07 28.4 10.6 7.3e-07 28.4 10.6 3.1 1 1 1 2 2 2 1 Sugar (and other) transporter DUF21 PF01595.20 EDK40643.2 - 7.3 6.3 9.4 3.3 7.4 2.8 2.4 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Cellulase PF00150.18 EDK40644.2 - 1.3e-16 60.9 12.3 2.1e-16 60.2 12.3 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) EpmC PF04315.12 EDK40644.2 - 0.068 12.9 0.6 0.2 11.4 0.6 1.7 2 0 0 2 2 2 0 Elongation factor P hydroxylase LIP PF03583.14 EDK40645.1 - 4.1e-107 357.8 0.3 4.9e-107 357.5 0.3 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 EDK40645.1 - 0.0049 16.4 2.8 0.59 9.6 0.0 2.7 3 0 0 3 3 3 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDK40645.1 - 0.063 12.5 0.1 1 8.5 0.1 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 MDM31_MDM32 PF08118.11 EDK40646.2 - 4.9e-26 91.5 0.1 6.2e-26 91.2 0.1 1.2 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins MDM31_MDM32 PF08118.11 EDK40647.2 - 3e-119 399.1 2.5 3.6e-119 398.8 2.5 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF202 PF02656.15 EDK40648.1 - 0.0041 17.5 2.0 0.0093 16.4 2.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF202) COX4_pro_2 PF07835.12 EDK40648.1 - 0.019 15.1 2.0 0.021 14.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV INO80_Ies4 PF08193.11 EDK40649.2 - 0.012 15.6 25.0 0.018 15.0 10.1 2.7 1 1 2 3 3 3 0 INO80 complex subunit Ies4 Glutaredoxin2_C PF04399.13 EDK40649.2 - 0.06 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain CDC27 PF09507.10 EDK40649.2 - 4.7 6.5 29.4 5.8 6.2 29.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 tRNA-synt_2b PF00587.25 EDK40650.2 - 1.6e-40 138.9 0.0 2.3e-40 138.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) CDC73_C PF05179.14 EDK40651.2 - 2.1e-50 170.4 0.2 3.6e-50 169.7 0.2 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal APG17 PF04108.12 EDK40652.2 - 3.8e-77 260.0 6.8 4.6e-77 259.8 6.8 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 FTCD_C PF04961.12 EDK40652.2 - 0.077 12.8 1.7 7.4 6.3 1.5 2.3 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase Tweety PF04906.13 EDK40652.2 - 0.2 10.3 3.6 13 4.3 3.1 2.4 2 0 0 2 2 2 0 Tweety NUC130_3NT PF08158.12 EDK40652.2 - 0.25 11.7 0.9 1.7 9.0 0.1 2.9 3 0 0 3 3 3 0 NUC130/3NT domain ADIP PF11559.8 EDK40652.2 - 0.27 11.3 7.1 0.066 13.3 3.2 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sec2p PF06428.11 EDK40652.2 - 0.94 9.5 9.1 4.1 7.4 5.4 2.5 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF5497 PF17601.2 EDK40652.2 - 1.2 9.4 4.5 9.3 6.6 0.1 3.3 3 1 1 4 4 4 0 Family of unknown function (DUF5497) Spc24 PF08286.11 EDK40652.2 - 3.7 7.8 9.9 0.57 10.5 1.0 3.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 zf-RING_9 PF13901.6 EDK40652.2 - 4.9 7.1 5.6 32 4.4 1.9 2.5 1 1 0 2 2 2 0 Putative zinc-RING and/or ribbon G-patch PF01585.23 EDK40653.2 - 8.6e-14 51.2 3.9 1.5e-13 50.4 3.9 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDK40653.2 - 1.7e-07 31.2 1.5 3.8e-07 30.1 1.5 1.6 1 0 0 1 1 1 1 G-patch domain CHCH PF06747.13 EDK40654.2 - 7.3e-07 29.2 2.1 1.2e-06 28.5 2.1 1.4 1 0 0 1 1 1 1 CHCH domain Tmemb_170 PF10190.9 EDK40654.2 - 0.11 12.9 0.1 0.17 12.3 0.1 1.2 1 0 0 1 1 1 0 Putative transmembrane protein 170 GCK PF07802.11 EDK40654.2 - 3.9 8.0 14.5 0.055 13.9 4.7 2.6 2 1 1 3 3 3 0 GCK domain Ras PF00071.22 EDK40655.2 - 1.5e-41 141.7 0.1 2.7e-41 140.9 0.1 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EDK40655.2 - 2.4e-33 114.9 0.1 4.8e-33 113.9 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK40655.2 - 9.9e-12 44.6 0.1 1.3e-11 44.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK40655.2 - 4.3e-08 32.8 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK40655.2 - 4.6e-05 23.5 0.0 7.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK40655.2 - 0.00011 21.9 0.1 0.00024 20.7 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EDK40655.2 - 0.013 15.3 0.2 0.51 10.1 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EDK40655.2 - 0.016 15.1 0.7 1 9.3 0.1 2.5 1 1 2 3 3 3 0 RsgA GTPase DAP3 PF10236.9 EDK40655.2 - 0.017 14.3 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EDK40655.2 - 0.034 14.5 0.0 0.11 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EDK40655.2 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EDK40655.2 - 0.15 12.1 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK40655.2 - 0.16 12.2 0.0 0.78 10.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain Synaptobrevin PF00957.21 EDK40656.1 - 1.5e-15 56.7 0.6 2.7e-15 55.9 0.6 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EDK40656.1 - 1.5e-11 44.1 0.0 3.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain SAM_2 PF07647.17 EDK40657.2 - 0.00035 20.6 0.2 0.0012 18.9 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDK40657.2 - 0.11 13.0 0.1 0.29 11.6 0.1 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PDEase_I PF00233.19 EDK40658.2 - 8.5e-53 179.5 2.1 4.2e-47 160.9 0.2 2.3 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase DUF5600 PF18150.1 EDK40658.2 - 0.0046 17.5 1.4 9.5 6.9 0.0 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF5600) HD PF01966.22 EDK40658.2 - 0.11 12.7 0.0 0.49 10.6 0.0 2.1 1 0 0 1 1 1 0 HD domain ABC_membrane PF00664.23 EDK40659.2 - 2.2e-58 198.1 39.4 1e-30 107.3 18.2 2.5 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK40659.2 - 1.4e-50 171.4 0.2 2.5e-29 102.6 0.2 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK40659.2 - 1.1e-11 44.6 8.3 0.00028 20.4 3.6 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDK40659.2 - 4.2e-06 26.8 0.3 0.087 12.9 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDK40659.2 - 1.3e-05 24.9 0.2 0.05 13.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDK40659.2 - 3.3e-05 23.8 0.0 0.051 13.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EDK40659.2 - 0.00031 20.6 4.6 0.33 10.7 0.0 4.0 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDK40659.2 - 0.00091 19.7 0.2 0.15 12.4 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 EDK40659.2 - 0.0012 19.0 1.0 1.3 9.1 0.1 3.0 3 0 0 3 3 2 2 Helicase HerA, central domain AAA_15 PF13175.6 EDK40659.2 - 0.0017 18.1 1.0 0.3 10.7 0.4 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EDK40659.2 - 0.0019 18.7 6.7 0.031 14.8 0.2 2.9 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EDK40659.2 - 0.0086 16.1 2.4 0.19 11.8 0.0 3.3 4 0 0 4 4 3 1 Dynamin family AAA_30 PF13604.6 EDK40659.2 - 0.0097 15.6 0.1 4.5 6.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EDK40659.2 - 0.019 14.3 1.0 0.72 9.2 0.1 2.7 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EDK40659.2 - 0.021 15.1 0.2 4.2 7.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDK40659.2 - 0.026 13.6 0.0 3.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EDK40659.2 - 0.032 14.1 0.1 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 EDK40659.2 - 0.033 14.6 0.4 1.9 8.9 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EDK40659.2 - 0.038 14.0 0.0 1.5 8.8 0.0 2.6 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EDK40659.2 - 0.07 12.0 0.1 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 EDK40659.2 - 0.15 12.5 0.1 22 5.5 0.0 3.0 3 0 0 3 3 2 0 RNA helicase TB2_DP1_HVA22 PF03134.19 EDK40659.2 - 7.2 6.6 9.0 4.7 7.2 0.1 4.1 3 0 0 3 3 3 0 TB2/DP1, HVA22 family Syntaxin_2 PF14523.6 EDK40660.2 - 0.012 15.9 7.5 0.13 12.6 4.8 2.4 2 0 0 2 2 2 0 Syntaxin-like protein DUF5601 PF18151.1 EDK40660.2 - 0.014 15.7 2.8 1.9 8.9 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) IFT57 PF10498.9 EDK40660.2 - 0.043 12.8 4.4 0.076 12.0 4.4 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 7TMR-HDED PF07697.11 EDK40660.2 - 0.055 13.6 1.7 0.33 11.1 1.7 2.1 1 1 0 1 1 1 0 7TM-HD extracellular Exonuc_VII_L PF02601.15 EDK40660.2 - 0.092 12.3 3.7 0.088 12.4 1.5 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit Hph PF13694.6 EDK40660.2 - 0.099 12.9 9.0 0.017 15.4 5.2 1.7 2 0 0 2 2 2 0 Sec63/Sec62 complex-interacting family Lectin_N PF03954.14 EDK40660.2 - 0.17 11.6 2.4 0.33 10.7 2.4 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF1043 PF06295.12 EDK40660.2 - 0.18 11.8 3.2 0.28 11.2 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF4335 PF14233.6 EDK40660.2 - 0.22 11.4 4.5 5.6 6.8 4.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4335) FAM76 PF16046.5 EDK40660.2 - 3.4 6.9 7.5 0.58 9.5 1.2 2.0 2 0 0 2 2 2 0 FAM76 protein NAD_binding_4 PF07993.12 EDK40661.2 - 6.8e-69 231.9 0.0 1.2e-68 231.0 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EDK40661.2 - 1.7e-66 224.6 0.0 2.4e-66 224.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDK40661.2 - 8.3e-13 48.5 0.0 2.9e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EDK40661.2 - 2.1e-07 31.8 0.5 9.2e-07 29.8 0.1 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 EDK40661.2 - 3.4e-07 30.0 0.0 5.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Condensation PF00668.20 EDK40661.2 - 0.0057 15.4 1.0 0.04 12.6 0.7 2.2 2 1 0 2 2 2 1 Condensation domain 3Beta_HSD PF01073.19 EDK40661.2 - 0.042 12.8 0.0 0.16 10.9 0.0 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PB1 PF00564.24 EDK40661.2 - 0.08 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 PB1 domain Per1 PF04080.13 EDK40662.2 - 1.6e-94 316.5 18.7 1.6e-94 316.5 18.7 1.5 2 0 0 2 2 2 1 Per1-like family TP_methylase PF00590.20 EDK40663.2 - 6e-25 88.4 0.1 1.1e-24 87.6 0.1 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases polyprenyl_synt PF00348.17 EDK40664.2 - 2.5e-48 164.4 0.1 3.1e-48 164.1 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DER1 PF04511.15 EDK40665.2 - 1.4e-23 83.8 3.8 1.4e-23 83.8 3.8 1.7 1 1 0 2 2 2 1 Der1-like family VPS9 PF02204.18 EDK40666.2 - 2.8e-09 37.1 0.1 5.4e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF4158 PF13700.6 EDK40669.2 - 0.017 14.9 2.0 0.023 14.5 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) LRR_4 PF12799.7 EDK40670.2 - 1.1e-06 28.8 18.7 0.0004 20.7 0.1 4.6 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK40670.2 - 8.6e-05 22.2 11.0 0.014 15.1 0.2 3.7 1 1 2 3 3 3 3 Leucine rich repeat F-box-like PF12937.7 EDK40670.2 - 0.0011 18.8 2.7 0.008 16.1 0.2 3.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EDK40670.2 - 0.038 13.9 0.4 0.038 13.9 0.4 2.3 2 0 0 2 2 2 0 F-box domain LRR_1 PF00560.33 EDK40670.2 - 0.091 13.4 15.3 13 6.8 0.2 6.0 5 0 0 5 5 5 0 Leucine Rich Repeat FNIP PF05725.12 EDK40670.2 - 0.3 11.3 2.8 10 6.4 0.1 3.4 3 0 0 3 3 3 0 FNIP Repeat ABC_membrane PF00664.23 EDK40671.2 - 2.5e-54 184.8 6.9 3.2e-54 184.4 6.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDK40671.2 - 4.4e-34 117.9 0.0 9.9e-34 116.8 0.0 1.6 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EDK40671.2 - 4.6e-06 26.2 0.2 0.0011 18.5 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDK40671.2 - 0.00059 20.3 0.0 0.0023 18.3 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDK40671.2 - 0.00087 19.6 0.1 0.0078 16.5 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.14 EDK40671.2 - 0.0012 18.8 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EDK40671.2 - 0.0023 17.4 0.0 0.0042 16.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_ATPase PF09818.9 EDK40671.2 - 0.0035 16.2 0.4 0.0066 15.3 0.4 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_29 PF13555.6 EDK40671.2 - 0.006 16.3 0.1 0.021 14.5 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EDK40671.2 - 0.023 14.9 0.0 0.061 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EDK40671.2 - 0.028 15.0 0.0 0.072 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EDK40671.2 - 0.032 13.9 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DEAD PF00270.29 EDK40671.2 - 0.034 13.9 0.6 0.61 9.8 0.0 2.5 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 EDK40671.2 - 0.043 14.3 0.0 0.67 10.4 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.25 EDK40671.2 - 0.069 12.8 0.0 0.17 11.5 0.0 1.6 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RsgA_GTPase PF03193.16 EDK40671.2 - 0.094 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase 6PF2K PF01591.18 EDK40671.2 - 0.095 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase IstB_IS21 PF01695.17 EDK40671.2 - 0.16 11.7 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein SbcCD_C PF13558.6 EDK40671.2 - 0.51 10.6 2.3 3 8.2 0.6 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Glyco_transf_28 PF03033.20 EDK40672.2 - 2.8e-32 111.6 0.0 7e-32 110.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 EDK40672.2 - 8.2e-25 86.9 3.1 3.1e-20 72.2 0.0 3.3 3 0 0 3 3 3 2 GRAM domain UDPGT PF00201.18 EDK40672.2 - 4.2e-07 29.1 0.0 9.5e-07 28.0 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.29 EDK40672.2 - 2.8e-05 24.6 0.0 0.00037 21.0 0.0 3.0 2 1 0 2 2 2 1 PH domain Glyco_trans_4_4 PF13579.6 EDK40672.2 - 0.055 13.9 0.0 0.099 13.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Abhydrolase_1 PF00561.20 EDK40673.2 - 3.4e-51 174.4 0.0 4.1e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK40673.2 - 0.0031 18.1 0.0 0.0044 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Zn_clus PF00172.18 EDK40674.2 - 7.3e-10 38.8 8.2 1.2e-09 38.1 8.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK40674.2 - 1.1e-07 31.1 0.3 1.8e-06 27.2 0.2 2.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Mad3_BUB1_I_2 PF17014.5 EDK40674.2 - 0.027 14.6 1.0 0.076 13.1 1.0 1.7 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein WD40 PF00400.32 EDK40675.2 - 9.7e-17 61.1 14.6 4.7e-05 24.1 0.1 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40675.2 - 1.1e-08 35.3 0.0 0.35 11.2 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 EDK40675.2 - 0.0064 15.2 0.0 0.013 14.2 0.0 1.5 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal Ge1_WD40 PF16529.5 EDK40675.2 - 0.056 12.4 0.0 8.1 5.3 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Thioredoxin PF00085.20 EDK40676.2 - 1.2e-52 176.2 0.2 3e-27 94.6 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EDK40676.2 - 4.7e-28 98.3 0.5 5.9e-23 81.7 2.6 2.7 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDK40676.2 - 5.7e-11 42.3 0.1 0.00028 20.3 0.0 3.3 4 0 0 4 4 4 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDK40676.2 - 4e-09 36.9 0.6 0.0014 19.0 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDK40676.2 - 3.3e-06 27.3 0.2 0.054 13.8 0.0 3.4 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EDK40676.2 - 6.9e-06 26.2 0.3 0.21 11.8 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EDK40676.2 - 0.001 19.0 0.8 0.23 11.4 0.0 3.3 4 0 0 4 4 4 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EDK40676.2 - 0.016 15.0 0.4 1.6 8.5 0.0 3.2 3 0 0 3 3 3 0 Thioredoxin Svf1 PF08622.10 EDK40677.2 - 2.6e-64 216.2 0.2 3.4e-64 215.8 0.2 1.1 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Svf1_C PF17187.4 EDK40677.2 - 6.7e-12 45.5 1.9 9.4e-12 45.1 0.9 1.7 2 1 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain ABC2_membrane PF01061.24 EDK40678.2 - 5.2e-36 124.1 13.6 5.2e-36 124.1 13.6 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EDK40678.2 - 3.5e-26 92.4 0.0 6.3e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EDK40678.2 - 1.6e-08 34.1 9.3 1.6e-08 34.1 9.3 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EDK40678.2 - 5.7e-06 26.3 0.1 0.05 13.4 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDK40678.2 - 0.02 14.8 0.1 0.04 13.8 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EDK40678.2 - 0.021 15.1 0.0 0.1 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EDK40678.2 - 0.023 14.4 0.1 0.05 13.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EDK40678.2 - 0.028 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EDK40678.2 - 0.13 12.5 0.3 0.22 11.8 0.3 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane_2 PF12679.7 EDK40678.2 - 3.9 6.7 14.5 0.048 12.9 6.6 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein UCH PF00443.29 EDK40679.2 - 2.1e-46 158.5 0.5 4.6e-46 157.4 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EDK40679.2 - 6.4e-44 147.7 15.5 1e-14 54.2 0.7 4.6 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.6 EDK40679.2 - 2.3e-06 27.5 2.9 5.2e-05 23.0 2.9 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FliD_C PF07195.12 EDK40679.2 - 0.0068 15.9 0.4 0.17 11.3 0.0 2.8 2 1 1 3 3 3 1 Flagellar hook-associated protein 2 C-terminus ABC_tran_CTD PF16326.5 EDK40679.2 - 0.035 14.4 1.2 0.086 13.1 0.0 2.2 3 0 0 3 3 3 0 ABC transporter C-terminal domain BCS1_N PF08740.11 EDK40680.2 - 1e-45 156.0 0.0 1.4e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDK40680.2 - 9.6e-23 81.1 0.0 1.6e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDK40680.2 - 0.0012 19.3 0.0 0.0049 17.3 0.0 2.0 2 1 0 2 2 1 1 AAA ATPase domain RuvB_N PF05496.12 EDK40680.2 - 0.0021 17.9 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDK40680.2 - 0.0024 18.4 0.0 0.0066 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDK40680.2 - 0.0025 17.0 0.0 0.004 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EDK40680.2 - 0.0025 17.8 0.0 0.014 15.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EDK40680.2 - 0.0068 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDK40680.2 - 0.0092 15.5 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 EDK40680.2 - 0.011 16.3 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 EDK40680.2 - 0.014 15.2 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 EDK40680.2 - 0.018 15.4 0.0 0.048 14.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 EDK40680.2 - 0.018 14.7 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EDK40680.2 - 0.019 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EDK40680.2 - 0.046 13.1 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 EDK40680.2 - 0.05 13.9 0.0 0.2 11.9 0.0 1.9 1 1 1 2 2 2 0 AAA domain NACHT PF05729.12 EDK40680.2 - 0.051 13.5 0.0 0.31 10.9 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Rad17 PF03215.15 EDK40680.2 - 0.1 12.5 0.0 0.66 9.9 0.0 2.2 2 1 1 3 3 3 0 Rad17 P-loop domain TsaE PF02367.17 EDK40680.2 - 0.1 12.6 0.0 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EDK40680.2 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDK40680.2 - 0.13 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EDK40680.2 - 0.15 11.6 0.0 0.64 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDK40680.2 - 0.2 12.2 0.0 0.56 10.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain HSF_DNA-bind PF00447.17 EDK40681.2 - 1.2e-28 99.5 1.2 2.4e-28 98.6 1.2 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Tcp11 PF05794.13 EDK40682.2 - 2.7e-140 468.4 0.6 3.4e-140 468.0 0.6 1.1 1 0 0 1 1 1 1 T-complex protein 11 PdaC PF13739.6 EDK40684.2 - 5.1 8.1 7.4 6.6 7.8 1.1 2.4 2 0 0 2 2 2 0 Deacetylase PdaC Glyco_hydro_92 PF07971.12 EDK40685.2 - 1.4e-147 492.4 7.0 1.7e-147 492.1 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EDK40685.2 - 1.3e-51 175.9 7.2 2e-51 175.2 7.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Pkinase PF00069.25 EDK40686.2 - 2.6e-50 171.2 0.0 5.2e-50 170.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40686.2 - 2.3e-28 99.2 0.0 3.2e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK40686.2 - 0.0071 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK40686.2 - 0.0085 15.5 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK40686.2 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDK40686.2 - 0.17 11.5 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 EDK40687.2 - 1.4e-71 241.0 0.0 1.6e-71 240.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40687.2 - 1.3e-28 100.0 0.0 1.8e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK40687.2 - 1.5e-05 24.2 0.1 6.4e-05 22.1 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDK40687.2 - 0.00098 19.1 0.1 0.0057 16.6 0.1 1.9 1 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDK40687.2 - 0.0016 17.6 0.2 0.0025 16.9 0.2 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EDK40687.2 - 0.0021 17.4 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK40687.2 - 0.016 14.6 0.6 0.041 13.2 0.6 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Lge1 PF11488.8 EDK40688.2 - 9.1e-19 67.4 1.8 1.3e-18 67.0 1.8 1.2 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 GPS2_interact PF15784.5 EDK40688.2 - 0.0017 18.7 1.0 0.0028 18.0 0.7 1.6 1 1 0 1 1 1 1 G-protein pathway suppressor 2-interacting domain HIP1_clath_bdg PF16515.5 EDK40688.2 - 0.011 16.3 0.9 0.015 15.8 0.9 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Golgin_A5 PF09787.9 EDK40688.2 - 0.03 13.8 2.9 0.045 13.2 2.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 ADIP PF11559.8 EDK40688.2 - 0.12 12.4 3.2 0.19 11.8 3.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding adh_short PF00106.25 EDK40689.1 - 3.5e-37 127.8 0.3 4.9e-37 127.3 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK40689.1 - 8.6e-22 77.8 0.1 1.2e-21 77.4 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK40689.1 - 2e-06 27.8 0.0 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EDK40689.1 - 0.0025 17.0 0.5 0.0035 16.5 0.5 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EDK40689.1 - 0.011 15.7 0.5 0.021 14.8 0.1 1.7 2 0 0 2 2 2 0 NAD(P)H-binding 3HCDH_N PF02737.18 EDK40689.1 - 0.027 14.3 0.5 0.07 13.0 0.5 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDK40689.1 - 0.041 14.0 0.0 0.081 13.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EDK40689.1 - 0.062 13.9 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent FAM76 PF16046.5 EDK40690.2 - 3.2 7.0 7.3 4.5 6.5 7.3 1.1 1 0 0 1 1 1 0 FAM76 protein NPR3 PF03666.13 EDK40690.2 - 6.5 5.4 10.3 8.4 5.1 10.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DnaJ_C PF01556.18 EDK40691.2 - 1.4e-37 129.1 0.0 1.8e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDK40691.2 - 6.9e-23 80.6 0.2 1e-22 80.0 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 EDK40692.2 - 3.6e-43 144.7 22.0 1.2e-08 35.4 0.0 8.1 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40692.2 - 3.3e-13 49.7 5.0 0.0052 17.1 0.2 5.4 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK40692.2 - 7.9e-09 34.7 13.2 0.0054 15.4 0.3 4.9 3 1 1 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDK40692.2 - 4.8e-07 29.0 2.2 0.086 11.8 0.0 4.5 1 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EDK40692.2 - 1.3e-05 24.5 0.0 0.033 13.3 0.0 2.7 1 1 2 3 3 3 2 VID27 C-terminal WD40-like domain Nucleoporin_N PF08801.11 EDK40692.2 - 0.00013 20.9 1.9 0.042 12.6 0.1 3.9 1 1 3 4 4 4 1 Nup133 N terminal like Hira PF07569.11 EDK40692.2 - 0.0007 19.4 4.4 1.5 8.5 0.1 4.0 2 1 2 5 5 5 2 TUP1-like enhancer of split PALB2_WD40 PF16756.5 EDK40692.2 - 0.0014 17.7 2.7 0.005 15.8 0.0 2.8 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EDK40692.2 - 0.0019 16.6 0.2 0.036 12.4 0.0 2.5 1 1 2 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EDK40692.2 - 0.11 11.9 0.0 6.6 6.0 0.0 2.5 1 1 1 2 2 2 0 WD40-like domain SET PF00856.28 EDK40693.2 - 4.8e-09 36.8 0.1 9.9e-09 35.8 0.1 1.6 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 EDK40693.2 - 0.007 16.4 17.3 0.007 16.4 17.3 3.3 3 0 0 3 3 3 1 MYND finger RFX_DNA_binding PF02257.15 EDK40694.2 - 8.6e-27 93.6 0.2 2.8e-26 92.0 0.0 2.0 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 EDK40694.2 - 0.054 14.0 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Poxvirus D5 protein-like Cdc6_C PF09079.11 EDK40694.2 - 0.092 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain DUF2497 PF10691.9 EDK40694.2 - 0.19 12.2 0.6 0.53 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) Ribosomal_L30 PF00327.20 EDK40695.2 - 9.3e-10 38.3 0.2 2.1e-09 37.1 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF4988 PF16378.5 EDK40695.2 - 0.13 11.9 2.8 7.1 6.3 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function Dcc1 PF09724.9 EDK40696.2 - 1.3e-60 205.5 0.0 1.5e-60 205.3 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Mito_carr PF00153.27 EDK40697.2 - 3.5e-31 107.0 0.1 4.4e-17 61.8 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein RRM_1 PF00076.22 EDK40698.2 - 1.2e-49 166.0 1.1 5.7e-14 51.7 0.0 5.5 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK40698.2 - 1.2e-06 28.6 0.1 0.055 13.6 0.0 4.0 3 0 0 3 3 3 3 RNA recognition motif CENP-N PF05238.13 EDK40699.2 - 1.1e-106 357.6 0.0 1.3e-106 357.4 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Vps16_N PF04841.13 EDK40700.2 - 9.1e-51 172.9 0.3 3.9e-49 167.5 0.3 2.7 1 1 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EDK40700.2 - 9.4e-36 123.5 8.8 1.4e-24 86.7 4.6 2.5 3 0 0 3 3 3 2 Vps16, C-terminal region Skp1_POZ PF03931.15 EDK40701.2 - 2.3e-06 27.7 0.1 6.6e-06 26.2 0.1 1.7 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain CLTH PF10607.9 EDK40702.2 - 2.5e-26 92.4 3.6 5.6e-26 91.2 3.6 1.6 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EDK40702.2 - 3.4e-05 23.8 0.1 8.5e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger PyrI_C PF02748.15 EDK40702.2 - 0.064 13.2 0.4 0.14 12.0 0.4 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain AdoMet_MTase PF07757.13 EDK40703.2 - 1.1e-42 144.9 0.1 1.9e-42 144.1 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EDK40703.2 - 0.19 11.7 0.1 4.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 EDK40704.1 - 8.7e-75 251.5 0.0 1e-74 251.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40704.1 - 8.8e-35 120.2 0.0 1.1e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK40704.1 - 0.0021 17.0 0.0 0.028 13.4 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain DisA-linker PF10635.9 EDK40704.1 - 0.054 13.3 0.1 0.09 12.5 0.1 1.2 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region Kinase-like PF14531.6 EDK40704.1 - 0.084 12.2 0.1 0.14 11.5 0.1 1.6 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 EDK40704.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PYRIN PF02758.16 EDK40705.2 - 0.071 13.3 0.3 2.1 8.5 0.1 2.6 2 1 1 3 3 3 0 PAAD/DAPIN/Pyrin domain Fibrillarin_2 PF10113.9 EDK40705.2 - 0.11 11.1 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein ICL PF00463.21 EDK40706.1 - 0 1030.1 2.8 0 1029.9 2.8 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDK40706.1 - 1.3e-11 44.4 0.0 6.5e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase AEP1 PF17049.5 EDK40706.1 - 0.23 10.5 0.5 0.55 9.3 0.5 1.5 2 0 0 2 2 2 0 ATPase expression protein 1 PQ-loop PF04193.14 EDK40707.2 - 6.4e-12 45.1 12.7 8.8e-08 31.8 1.6 3.5 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 EDK40707.2 - 1.1 10.0 12.9 0.056 14.3 2.5 2.9 3 0 0 3 3 3 0 ER lumen protein retaining receptor MtN3_slv PF03083.16 EDK40707.2 - 2.2 8.4 13.1 0.29 11.2 0.5 2.7 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange zf-C2H2 PF00096.26 EDK40708.2 - 1.1e-06 28.7 1.9 0.0076 16.6 0.7 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 EDK40708.2 - 0.019 15.2 0.2 0.054 13.8 0.2 1.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EDK40708.2 - 0.021 15.6 5.7 1.9 9.6 0.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf_ZIC PF18366.1 EDK40708.2 - 0.023 14.8 0.0 0.14 12.3 0.0 2.1 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_jaz PF12171.8 EDK40708.2 - 0.43 10.9 2.3 2.6 8.4 0.2 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EDK40708.2 - 1.7 9.2 3.5 34 5.1 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger double domain His_Phos_1 PF00300.22 EDK40709.2 - 6.2e-34 117.4 0.0 5.5e-24 84.9 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF3605 PF12239.8 EDK40710.2 - 7.9e-51 172.4 2.2 9.6e-51 172.1 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) FMN_dh PF01070.18 EDK40710.2 - 0.22 10.5 0.0 0.38 9.7 0.0 1.3 1 1 0 1 1 1 0 FMN-dependent dehydrogenase CENP-T_C PF15511.6 EDK40711.1 - 9.1e-10 38.6 0.1 1.1e-09 38.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EDK40711.1 - 1.4e-05 25.2 0.1 1.9e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDK40711.1 - 2e-05 24.8 0.1 3.4e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDK40711.1 - 5.8e-05 23.5 0.1 6.7e-05 23.3 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDK40711.1 - 8e-05 22.9 0.1 0.00011 22.5 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EDK40711.1 - 0.0025 17.9 0.0 0.003 17.6 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDK40711.1 - 0.0066 16.4 0.0 0.0078 16.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated UPF0137 PF03677.13 EDK40711.1 - 0.01 15.6 0.2 0.013 15.3 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TAFII28 PF04719.14 EDK40711.1 - 0.06 13.4 0.0 0.071 13.2 0.0 1.1 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TFIID_20kDa PF03847.13 EDK40711.1 - 0.077 13.5 0.1 0.16 12.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 EDK40712.1 - 5.3e-51 172.4 2.8 5.9e-51 172.2 2.8 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDK40712.1 - 3.8e-06 27.2 0.0 5.8e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDK40712.1 - 5e-05 23.4 0.5 8e-05 22.7 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDK40712.1 - 5.6e-05 23.7 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDK40712.1 - 0.0052 17.0 0.6 0.0079 16.5 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDK40712.1 - 0.023 14.8 0.1 0.039 14.0 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DUF3445 PF11927.8 EDK40713.2 - 5.3e-74 248.7 0.0 6.6e-74 248.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Mannosyl_trans2 PF04188.13 EDK40714.2 - 2.1e-48 165.8 30.9 1.9e-41 142.8 21.3 2.0 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V) AMP-binding PF00501.28 EDK40715.2 - 2.3e-69 234.0 0.3 2.9e-69 233.7 0.0 1.3 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDK40715.2 - 1e-25 90.5 2.1 1.5e-25 89.9 0.8 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HSP70 PF00012.20 EDK40716.1 - 2.5e-260 864.8 10.3 2.9e-260 864.6 10.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDK40716.1 - 1.1e-17 63.8 0.0 1.6e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EDK40716.1 - 0.00071 19.4 0.0 0.0078 16.0 0.0 2.3 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EDK40716.1 - 0.015 14.6 0.1 0.08 12.2 0.0 2.1 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase Septin PF00735.18 EDK40717.2 - 6.2e-104 347.2 0.1 6.2e-104 347.2 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDK40717.2 - 1e-05 25.6 0.5 2.1e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDK40717.2 - 2.3e-05 24.7 0.4 0.00023 21.4 0.0 2.7 2 2 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EDK40717.2 - 0.00032 20.6 3.6 0.038 13.9 0.0 2.7 3 0 0 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 EDK40717.2 - 0.0018 17.8 0.0 0.0036 16.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Strep_SA_rep PF06696.11 EDK40717.2 - 0.0054 16.7 2.1 0.0054 16.7 2.1 2.1 2 0 0 2 2 2 1 Streptococcal surface antigen repeat AAA_16 PF13191.6 EDK40717.2 - 0.0078 16.6 0.1 0.045 14.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.6 EDK40717.2 - 0.017 15.4 0.2 0.029 14.7 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EDK40717.2 - 0.032 14.6 1.5 0.19 12.2 0.0 2.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EDK40717.2 - 0.052 13.3 0.8 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EDK40717.2 - 0.099 12.9 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EDK40717.2 - 0.12 12.0 0.1 0.37 10.4 0.1 2.0 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EDK40717.2 - 0.14 12.7 10.4 2.4 8.6 9.5 2.3 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 EDK40717.2 - 0.17 11.5 7.2 0.26 10.8 7.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ABC_tran PF00005.27 EDK40717.2 - 0.2 12.2 4.6 0.92 10.0 0.1 2.5 2 1 0 2 2 2 0 ABC transporter FAM76 PF16046.5 EDK40717.2 - 0.76 9.1 8.5 1.1 8.5 8.5 1.3 1 0 0 1 1 1 0 FAM76 protein CinA PF02464.17 EDK40718.2 - 3.2e-30 104.7 0.0 4e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Competence-damaged protein HlyD_D4 PF16572.5 EDK40718.2 - 0.071 13.0 0.0 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Long alpha hairpin domain of cation efflux system protein, CusB Proteasom_Rpn13 PF04683.13 EDK40719.1 - 3.3e-25 88.5 0.0 4.7e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Pkinase PF00069.25 EDK40720.2 - 5.6e-49 166.9 0.0 7.2e-31 107.5 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40720.2 - 7.9e-24 84.3 0.0 1.6e-21 76.8 0.0 3.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK40720.2 - 0.018 14.3 0.2 5 6.3 0.0 2.6 3 0 0 3 3 3 0 Kinase-like Serglycin PF04360.12 EDK40720.2 - 1 9.3 7.7 0.92 9.4 4.5 2.6 2 0 0 2 2 2 0 Serglycin DUF3543 PF12063.8 EDK40721.2 - 8e-86 287.5 0.2 1.7e-85 286.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EDK40721.2 - 8.5e-63 212.2 0.0 1.7e-62 211.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40721.2 - 2.1e-44 151.8 0.0 3.3e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK40721.2 - 0.00027 20.4 0.0 0.0063 15.9 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EDK40721.2 - 0.048 12.4 0.0 0.15 10.8 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase DUF1690 PF07956.11 EDK40721.2 - 0.46 10.9 4.7 3.3 8.1 2.6 2.6 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) VPS13_mid_rpt PF16910.5 EDK40722.2 - 5.5e-86 287.8 15.0 1.3e-84 283.3 0.6 5.4 6 1 0 6 6 6 3 Repeating coiled region of VPS13 VPS13 PF16908.5 EDK40722.2 - 3e-80 269.4 10.1 3.2e-75 253.0 3.1 3.9 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EDK40722.2 - 1.3e-41 141.4 0.4 4.8e-41 139.5 0.4 2.1 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 HisKA_3 PF07730.13 EDK40722.2 - 0.29 11.7 1.3 0.73 10.4 0.1 2.4 3 0 0 3 3 3 0 Histidine kinase DUF4570 PF15134.6 EDK40722.2 - 3.1 7.9 6.3 1.4 9.0 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) LTXXQ PF07813.12 EDK40722.2 - 7 7.4 9.5 3.4 8.4 1.5 3.3 4 0 0 4 4 4 0 LTXXQ motif family protein SHR-BD PF06650.12 EDK40724.2 - 9.3e-90 300.7 5.0 1.2e-89 300.3 1.0 2.5 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 EDK40724.2 - 5.8e-75 251.0 6.4 4.8e-68 228.4 0.3 2.5 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 EDK40724.2 - 3.8e-06 27.2 0.0 8.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Apt1 PF10351.9 EDK40724.2 - 0.019 13.9 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Formyl_trans_N PF00551.19 EDK40725.2 - 6.1e-32 110.8 0.0 9e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EDK40725.2 - 4.1e-09 36.6 0.1 6.8e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Nodulin-like PF06813.13 EDK40726.2 - 1.1e-16 61.1 6.6 1.1e-16 61.1 6.6 3.1 2 1 1 3 3 3 1 Nodulin-like MFS_1 PF07690.16 EDK40726.2 - 3.8e-10 39.2 32.4 3.8e-10 39.2 32.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4774 PF15999.5 EDK40726.2 - 0.16 11.8 1.9 0.25 11.2 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4774) PepSY_TM PF03929.16 EDK40726.2 - 5.2 6.6 7.7 0.094 12.4 0.3 2.0 3 0 0 3 3 3 0 PepSY-associated TM region Sacchrp_dh_NADP PF03435.18 EDK40728.2 - 1e-05 25.8 0.2 1.8e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 EDK40728.2 - 5e-05 23.3 0.1 0.00012 22.0 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DapB_N PF01113.20 EDK40728.2 - 0.013 15.6 0.2 0.031 14.4 0.2 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CoA_binding PF02629.19 EDK40728.2 - 0.041 14.6 0.2 0.17 12.6 0.0 2.1 2 0 0 2 2 2 0 CoA binding domain Semialdhyde_dh PF01118.24 EDK40728.2 - 0.057 13.9 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Ran-binding PF05508.11 EDK40729.2 - 0.00041 19.5 0.2 0.00049 19.2 0.2 1.1 1 0 0 1 1 1 1 RanGTP-binding protein zf-C4H2 PF10146.9 EDK40729.2 - 0.015 15.7 0.0 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4349 PF14257.6 EDK40729.2 - 0.15 11.5 0.3 0.44 10.0 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Trp_syntA PF00290.20 EDK40730.2 - 1e-90 303.1 0.2 1.4e-90 302.7 0.2 1.1 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EDK40730.2 - 3.9e-25 88.9 1.2 5e-25 88.5 0.2 1.6 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme SLS PF14611.6 EDK40730.2 - 0.13 12.1 0.0 0.27 11.0 0.0 1.5 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator SinI PF08671.10 EDK40730.2 - 0.2 11.5 0.0 0.71 9.7 0.0 2.0 1 0 0 1 1 1 0 Anti-repressor SinI Rrn6 PF10214.9 EDK40731.2 - 4.1e-65 220.8 34.7 1.5e-61 209.0 34.7 3.8 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Glyco_hydro_63 PF03200.16 EDK40732.2 - 1.6e-191 637.4 3.3 1.3e-190 634.4 3.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EDK40732.2 - 3.8e-73 246.3 0.0 1.3e-72 244.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EDK40732.2 - 5.9e-06 25.4 1.0 9.2e-06 24.8 1.0 1.2 1 0 0 1 1 1 1 Trehalase FhuF PF06276.12 EDK40732.2 - 0.0065 16.9 0.0 0.083 13.3 0.0 2.3 2 0 0 2 2 2 1 Ferric iron reductase FhuF-like transporter GDE_C PF06202.14 EDK40732.2 - 0.0068 15.4 0.2 0.036 13.0 0.2 2.0 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase 5_nucleotid_C PF02872.18 EDK40733.2 - 0.064 13.5 0.0 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain Ribosomal_S4e PF00900.20 EDK40734.1 - 2.9e-37 126.4 0.3 9.3e-37 124.8 0.1 1.8 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDK40734.1 - 1.1e-24 85.8 0.1 2e-24 84.9 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EDK40734.1 - 2.4e-21 75.6 6.1 1.1e-20 73.4 6.4 2.0 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.25 EDK40734.1 - 4.9e-08 32.6 0.0 9.6e-08 31.6 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EDK40734.1 - 3.3e-05 23.7 1.8 3.3e-05 23.7 1.8 3.1 3 0 0 3 3 3 1 KOW motif RabGAP-TBC PF00566.18 EDK40735.2 - 8.3e-48 162.9 3.1 8.3e-48 162.9 3.1 2.7 4 0 0 4 4 3 1 Rab-GTPase-TBC domain Fib_alpha PF08702.10 EDK40735.2 - 8.6e-05 22.7 4.9 8.6e-05 22.7 4.9 3.3 2 1 1 3 3 3 1 Fibrinogen alpha/beta chain family DUF4945 PF16303.5 EDK40735.2 - 0.0025 17.7 0.7 3.3 7.7 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4945) Uso1_p115_C PF04871.13 EDK40735.2 - 0.007 16.7 11.5 0.007 16.7 11.5 2.9 3 1 0 3 3 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region GAS PF13851.6 EDK40735.2 - 0.0078 15.6 16.0 1.2 8.4 8.3 3.4 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EDK40735.2 - 0.012 15.7 4.6 0.012 15.7 4.6 3.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lectin_N PF03954.14 EDK40735.2 - 0.017 14.9 5.4 0.71 9.6 0.2 3.4 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain OmpH PF03938.14 EDK40735.2 - 0.018 15.4 10.7 0.029 14.7 5.5 2.9 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Syntaxin-6_N PF09177.11 EDK40735.2 - 0.023 15.3 15.5 1.9 9.1 0.1 4.5 2 1 2 4 4 4 0 Syntaxin 6, N-terminal APG6_N PF17675.1 EDK40735.2 - 0.028 14.9 0.4 0.028 14.9 0.4 3.7 2 1 1 3 3 2 0 Apg6 coiled-coil region Prominin PF05478.11 EDK40735.2 - 0.044 11.8 8.6 0.16 9.9 3.9 2.3 2 0 0 2 2 2 0 Prominin MogR_DNAbind PF12181.8 EDK40735.2 - 0.053 13.4 1.1 0.15 11.9 0.2 2.2 2 0 0 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) PEP-utilisers_N PF05524.13 EDK40735.2 - 0.1 12.8 6.5 0.073 13.2 3.3 2.5 2 1 1 3 3 2 0 PEP-utilising enzyme, N-terminal Flg_hook PF02120.16 EDK40735.2 - 0.64 10.0 4.9 24 4.9 0.0 3.5 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK DUF5344 PF17279.2 EDK40735.2 - 0.78 10.4 13.8 0.52 10.9 6.4 3.3 3 1 0 3 3 2 0 Family of unknown function (DUF5344) Baculo_PEP_C PF04513.12 EDK40735.2 - 1.5 8.9 11.9 0.81 9.7 0.9 3.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 EDK40735.2 - 1.7 8.7 18.9 2 8.5 3.1 3.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 EDK40735.2 - 2.1 7.5 9.1 4 6.6 4.1 2.7 2 1 0 2 2 2 0 TMPIT-like protein Leu_zip PF15294.6 EDK40735.2 - 2.6 7.5 22.3 0.042 13.4 11.7 2.8 3 0 0 3 3 2 0 Leucine zipper bZIP_2 PF07716.15 EDK40735.2 - 3.5 7.8 16.6 2.3 8.3 0.4 3.9 3 1 0 3 3 3 0 Basic region leucine zipper CCDC-167 PF15188.6 EDK40735.2 - 4.4 7.7 11.5 21 5.6 6.3 3.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 EDK40735.2 - 4.6 7.3 11.4 8 6.5 2.0 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 EDK40735.2 - 6.2 6.6 13.2 0.67 9.8 4.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF724) YabA PF06156.13 EDK40735.2 - 6.4 7.5 20.1 0.2 12.3 0.7 4.8 3 1 2 5 5 4 0 Initiation control protein YabA ABC_tran_CTD PF16326.5 EDK40735.2 - 6.5 7.1 17.9 0.13 12.6 2.6 3.6 2 1 1 3 3 3 0 ABC transporter C-terminal domain Fungal_TACC PF12709.7 EDK40735.2 - 7.6 7.1 12.8 3.6 8.1 0.1 4.4 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Cnn_1N PF07989.11 EDK40735.2 - 7.9 6.7 18.0 0.035 14.3 3.8 3.4 3 0 0 3 3 2 0 Centrosomin N-terminal motif 1 FapA PF03961.13 EDK40735.2 - 10 4.6 12.3 38 2.7 10.1 2.6 2 1 0 2 2 2 0 Flagellar Assembly Protein A IMS_C PF11799.8 EDK40736.2 - 0.0093 16.7 0.3 0.98 10.1 0.3 2.6 1 1 0 1 1 1 1 impB/mucB/samB family C-terminal domain LcrG PF07216.12 EDK40736.2 - 0.1 12.5 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 LcrG protein LigT_PEase PF02834.16 EDK40736.2 - 0.13 12.4 0.3 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 LigT like Phosphoesterase Zn_clus PF00172.18 EDK40737.2 - 2.5e-09 37.1 15.6 5.5e-09 36.0 15.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EDK40737.2 - 0.00032 20.8 0.0 0.00072 19.7 0.0 1.6 1 0 0 1 1 1 1 Gal4-like dimerisation domain UQ_con PF00179.26 EDK40738.2 - 3e-24 85.2 0.0 3.6e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EDK40738.2 - 9.3e-05 22.3 0.1 0.00013 21.8 0.1 1.2 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 EDK40738.2 - 0.0002 21.0 0.0 0.00026 20.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RQC PF09382.10 EDK40739.2 - 2.9e-24 85.0 0.5 7.9e-24 83.6 0.1 2.0 2 0 0 2 2 2 1 RQC domain DEAD PF00270.29 EDK40739.2 - 2e-22 79.8 0.0 4.7e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK40739.2 - 4.8e-21 75.2 0.1 1e-14 54.8 0.0 3.6 3 1 2 5 5 5 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EDK40739.2 - 3.4e-17 62.9 8.2 1.1e-16 61.3 8.2 2.0 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EDK40739.2 - 1.6e-05 25.0 0.0 4.5e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HRDC PF00570.23 EDK40739.2 - 0.0011 18.9 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 HRDC domain SNF2_N PF00176.23 EDK40739.2 - 0.0084 14.9 0.0 0.014 14.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_Sgs1 PF11408.8 EDK40739.2 - 0.063 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase zf-CCCH PF00642.24 EDK40740.2 - 1.5e-19 69.3 14.8 4.3e-12 45.6 1.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDK40740.2 - 2e-07 30.8 20.3 3.8e-05 23.6 2.3 2.2 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EDK40740.2 - 1.4e-06 27.9 14.7 0.0037 17.0 7.0 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EDK40740.2 - 0.0035 18.0 15.0 0.004 17.8 3.1 2.2 1 1 1 2 2 2 2 Torus domain Defensin_int PF17858.1 EDK40740.2 - 0.11 12.5 4.9 0.44 10.6 1.7 2.2 2 0 0 2 2 2 0 Platypus intermediate defensin-like peptide zf-CCCH_2 PF14608.6 EDK40740.2 - 0.68 10.5 13.6 1.1 9.8 0.6 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Gcn1_N PF12074.8 EDK40741.2 - 7.9e-58 196.5 0.3 7.9e-58 196.5 0.3 4.8 4 1 1 5 5 5 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_EZ PF13513.6 EDK40741.2 - 1.5e-30 105.2 23.9 0.0034 17.9 0.1 16.6 16 1 0 17 17 17 7 HEAT-like repeat HEAT PF02985.22 EDK40741.2 - 2.7e-28 95.6 29.8 0.064 13.6 0.0 21.3 27 0 0 27 27 22 6 HEAT repeat HEAT_2 PF13646.6 EDK40741.2 - 7.2e-24 84.0 33.9 0.00018 21.8 0.1 15.6 14 4 5 19 19 18 8 HEAT repeats Cnd1 PF12717.7 EDK40741.2 - 1.9e-19 70.3 14.8 0.015 15.3 0.1 11.9 6 3 3 11 11 11 6 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDK40741.2 - 2.7e-17 63.1 0.3 0.0059 16.2 0.0 9.9 10 3 3 13 13 13 3 CLASP N terminal Vac14_Fab1_bd PF12755.7 EDK40741.2 - 3.1e-15 56.5 1.1 0.52 11.0 0.0 9.8 9 2 3 12 12 12 3 Vacuolar 14 Fab1-binding region FANCI_S2 PF14676.6 EDK40741.2 - 3.5e-06 27.4 7.7 0.048 14.0 0.1 5.6 6 0 0 6 6 5 2 FANCI solenoid 2 DUF3385 PF11865.8 EDK40741.2 - 3.5e-06 27.0 1.0 11 5.9 0.0 8.1 8 4 1 9 9 9 0 Domain of unknown function (DUF3385) Tti2 PF10521.9 EDK40741.2 - 0.0039 16.8 0.0 2.1 7.8 0.0 4.2 3 1 1 4 4 4 1 Tti2 family IFRD PF05004.13 EDK40741.2 - 0.0052 15.9 21.0 0.49 9.5 0.0 7.8 8 1 1 9 9 9 1 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 EDK40741.2 - 0.062 13.5 7.0 28 5.0 0.0 6.6 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 RIX1 PF08167.12 EDK40741.2 - 0.25 11.0 14.2 7.3 6.3 0.1 7.1 7 1 0 7 7 7 0 rRNA processing/ribosome biogenesis HEAT_PBS PF03130.16 EDK40741.2 - 1.4 9.8 6.8 98 4.1 0.0 6.5 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat TFCD_C PF12612.8 EDK40741.2 - 1.8 8.4 6.2 4.3 7.1 0.0 4.3 4 1 0 4 4 4 0 Tubulin folding cofactor D C terminal TipAS PF07739.13 EDK40741.2 - 2.2 8.8 4.5 63 4.2 0.0 3.8 4 0 0 4 4 4 0 TipAS antibiotic-recognition domain TIP120 PF08623.10 EDK40741.2 - 2.9 7.6 13.1 2.8 7.7 0.0 6.6 8 0 0 8 8 8 0 TATA-binding protein interacting (TIP20) zf-C2H2 PF00096.26 EDK40742.2 - 1.6e-07 31.3 15.7 0.00037 20.8 4.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK40742.2 - 6.1e-07 29.6 19.2 0.00024 21.4 4.7 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK40742.2 - 0.0014 19.3 13.3 0.08 13.8 3.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK40742.2 - 0.085 13.2 0.5 0.23 11.8 0.5 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EDK40742.2 - 0.12 13.1 1.8 0.44 11.2 0.1 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 EDK40742.2 - 2.9 7.7 12.8 3.6 7.4 0.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain RTA1 PF04479.13 EDK40743.2 - 1.4e-35 122.8 16.4 2.4e-35 122.0 16.4 1.4 1 1 0 1 1 1 1 RTA1 like protein DUF4126 PF13548.6 EDK40743.2 - 0.0016 18.2 4.8 0.0036 17.0 4.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4126) Fungal_trans PF04082.18 EDK40744.1 - 1.1e-13 50.8 0.1 2.7e-13 49.6 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK40744.1 - 6.5e-06 26.2 14.5 6.5e-06 26.2 14.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EDK40745.2 - 1.7e-85 287.6 33.2 2e-85 287.4 33.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40745.2 - 6.3e-25 87.8 36.7 1.9e-19 69.8 29.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CN_hydrolase PF00795.22 EDK40746.2 - 3.7e-10 39.6 0.0 4.4e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.22 EDK40747.2 - 2.9e-32 112.1 0.0 5.1e-32 111.2 0.0 1.4 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase rpo132 PF12415.8 EDK40747.2 - 0.078 12.3 2.5 1.5 8.1 0.1 3.2 3 0 0 3 3 3 0 Poxvirus DNA dependent RNA polymerase RRM_1 PF00076.22 EDK40748.2 - 3.7e-32 109.9 0.4 1.3e-15 57.0 0.1 3.7 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDK40748.2 - 0.0011 18.9 0.0 2.4 8.2 0.0 3.3 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EDK40748.2 - 0.0014 18.2 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK40748.2 - 0.012 15.7 0.0 0.53 10.4 0.0 3.3 3 1 0 3 3 3 0 RNA recognition motif RRM_3 PF08777.11 EDK40748.2 - 0.015 15.3 0.1 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 EDK40748.2 - 0.05 13.5 0.0 6.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EDK40748.2 - 0.093 13.0 0.1 6.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Zn_clus PF00172.18 EDK40749.1 - 4.5e-09 36.3 10.7 7e-09 35.7 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EDK40750.2 - 4e-13 49.0 1.2 7e-13 48.2 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Abhydrolase_1 PF00561.20 EDK40751.1 - 6e-09 35.9 0.0 5.4e-08 32.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK40751.1 - 4.5e-06 26.1 0.0 0.00046 19.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EDK40751.1 - 0.00066 19.4 0.0 0.00081 19.1 0.0 1.3 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EDK40751.1 - 0.0013 18.6 0.0 0.0037 17.2 0.0 1.6 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EDK40751.1 - 0.0014 18.2 0.1 0.0073 15.9 0.1 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EDK40751.1 - 0.0031 18.2 0.0 0.0041 17.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EDK40751.1 - 0.15 11.5 0.0 0.94 8.9 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family JAB PF01398.21 EDK40752.2 - 3.8e-30 104.3 0.1 1.2e-29 102.6 0.1 1.9 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDK40752.2 - 0.00029 20.6 0.0 0.00095 18.9 0.0 1.8 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain CDC45 PF02724.14 EDK40752.2 - 0.0037 15.7 10.5 0.0049 15.2 10.5 1.1 1 0 0 1 1 1 1 CDC45-like protein UPF0172 PF03665.13 EDK40752.2 - 0.015 15.4 0.0 0.015 15.4 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0172) UCH PF00443.29 EDK40753.2 - 1.3e-52 178.9 4.4 1.7e-52 178.4 4.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK40753.2 - 5.7e-19 68.9 9.9 1.9e-17 63.9 9.9 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDK40753.2 - 0.018 14.5 5.7 0.56 9.6 5.7 3.1 1 1 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase zinc_ribbon_15 PF17032.5 EDK40753.2 - 0.052 14.3 0.4 2.4 9.0 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon family Menin PF05053.13 EDK40753.2 - 1.1 7.5 22.3 0.044 12.1 14.4 1.9 2 0 0 2 2 2 0 Menin Yippee-Mis18 PF03226.14 EDK40754.2 - 6.8e-12 45.5 0.9 1.5e-11 44.4 0.9 1.6 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 EDK40754.2 - 0.0023 18.0 0.6 2.5 8.2 0.0 2.6 2 1 1 3 3 3 2 SelR domain Rsm1 PF08600.10 EDK40754.2 - 0.0064 16.6 0.5 0.13 12.4 0.1 2.2 2 0 0 2 2 2 1 Rsm1-like Transp_Tc5_C PF04236.15 EDK40754.2 - 0.0071 16.7 2.9 0.036 14.4 0.4 2.8 3 0 0 3 3 3 1 Tc5 transposase C-terminal domain zf-AN1 PF01428.16 EDK40754.2 - 0.055 13.6 1.7 0.21 11.8 0.2 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zinc_ribbon_10 PF10058.9 EDK40754.2 - 0.14 11.9 2.1 0.94 9.3 0.4 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein RIG-I_C-RD PF11648.8 EDK40754.2 - 0.19 11.9 2.8 0.84 9.9 2.8 1.9 1 1 0 1 1 1 0 C-terminal domain of RIG-I Tnp_zf-ribbon_2 PF13842.6 EDK40754.2 - 0.26 12.1 3.7 0.59 11.0 0.5 2.3 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon SOAR PF16533.5 EDK40755.2 - 0.17 11.9 0.8 0.32 11.0 0.8 1.5 1 0 0 1 1 1 0 STIM1 Orai1-activating region Crystallin PF00525.18 EDK40755.2 - 0.35 11.0 2.0 0.33 11.1 0.4 1.7 2 0 0 2 2 2 0 Alpha crystallin A chain, N terminal Ribosomal_L22 PF00237.19 EDK40756.2 - 1.2e-18 67.2 0.0 2e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e RRM_DME PF15628.6 EDK40756.2 - 0.16 12.1 0.1 0.34 11.1 0.1 1.4 1 0 0 1 1 1 0 RRM in Demeter Baculo_11_kDa PF06143.11 EDK40757.1 - 0.009 15.6 0.7 3.1 7.5 0.5 2.3 2 0 0 2 2 2 2 Baculovirus 11 kDa family PhoR PF11808.8 EDK40757.1 - 0.14 12.6 0.1 2 8.9 0.0 2.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Flo11 PF10182.9 EDK40758.2 - 3.4e-31 108.4 2.3 3.4e-31 108.4 2.3 2.2 2 0 0 2 2 2 1 Flo11 domain SHR3_chaperone PF08229.11 EDK40759.1 - 2.3e-69 232.1 0.5 2.8e-69 231.9 0.2 1.2 1 1 0 1 1 1 1 ER membrane protein SH3 Ras PF00071.22 EDK40760.2 - 4.8e-55 185.6 0.0 5.7e-55 185.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK40760.2 - 9.4e-21 74.3 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK40760.2 - 1.4e-07 31.2 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SNF2_N PF00176.23 EDK40760.2 - 0.11 11.2 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain RRM_1 PF00076.22 EDK40761.2 - 2.9e-09 36.6 0.0 5.7e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDK40761.2 - 0.034 14.3 0.0 0.14 12.2 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif CDC45 PF02724.14 EDK40761.2 - 0.093 11.0 8.3 0.11 10.7 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 EDK40762.2 - 1.4e-11 44.7 3.9 0.02 15.8 0.0 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40762.2 - 6e-07 29.7 0.1 1.5 9.2 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_3 PF15911.5 EDK40762.2 - 0.09 12.8 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat adh_short PF00106.25 EDK40763.2 - 1.6e-14 53.8 0.0 1.5e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDK40763.2 - 2.4e-07 30.6 0.0 0.00087 18.9 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK40763.2 - 4e-06 26.9 0.0 6.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EDK40763.2 - 0.016 14.6 0.0 0.016 14.6 0.0 2.2 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDK40763.2 - 0.14 11.3 1.8 0.39 9.8 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein Pkinase PF00069.25 EDK40764.2 - 4.5e-49 167.2 0.0 6.7e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40764.2 - 7.5e-23 81.1 0.0 1.1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDK40764.2 - 0.024 14.5 0.1 0.057 13.3 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDK40764.2 - 0.068 12.1 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Ribosomal_L11 PF00298.19 EDK40766.2 - 7.6e-27 93.6 0.3 1.2e-26 93.0 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDK40766.2 - 1.5e-25 88.8 0.5 2.6e-25 88.0 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain FAM176 PF14851.6 EDK40767.2 - 1 9.0 14.3 0.3 10.8 11.6 1.4 1 1 0 1 1 1 0 FAM176 family WD40 PF00400.32 EDK40769.2 - 5.9e-13 49.1 8.3 2.4e-05 25.0 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40769.2 - 0.0007 19.8 0.5 12 6.2 0.0 4.4 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDK40769.2 - 0.12 12.2 0.2 25 4.7 0.0 3.5 3 1 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A GDC-P PF02347.16 EDK40770.2 - 2.6e-193 642.7 0.0 6.6e-180 598.5 0.0 2.2 2 0 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EDK40770.2 - 4.7e-05 22.5 0.0 0.003 16.6 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V GTP_EFTU PF00009.27 EDK40771.1 - 2.7e-55 187.0 0.0 3.5e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDK40771.1 - 5.8e-12 45.8 2.0 5.8e-12 45.8 2.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK40771.1 - 0.00017 21.7 0.2 0.0056 16.7 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase CBS PF00571.28 EDK40772.2 - 5.1e-17 62.1 0.2 0.007 16.8 0.0 5.3 5 0 0 5 5 5 5 CBS domain FA_desaturase PF00487.24 EDK40773.2 - 1.3e-17 64.5 20.0 1.3e-17 64.5 20.0 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EDK40773.2 - 7.3e-15 54.9 0.0 1.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_hydro_31 PF01055.26 EDK40774.2 - 2.8e-119 399.2 0.1 3.6e-119 398.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EDK40774.2 - 1.5e-20 73.3 0.3 8.1e-20 70.9 0.4 2.3 2 0 0 2 2 2 1 Galactose mutarotase-like Peptidase_U32_C PF16325.5 EDK40774.2 - 0.058 13.7 0.1 0.77 10.1 0.1 2.4 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain Sugar_tr PF00083.24 EDK40775.2 - 8.5e-65 219.4 16.4 1.2e-64 218.8 16.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40775.2 - 2.5e-22 79.3 18.7 3.8e-22 78.7 18.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK40775.2 - 2.7e-05 23.6 1.4 5.7e-05 22.6 1.4 1.6 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 EDK40775.2 - 0.001 17.7 15.7 0.009 14.6 1.2 2.4 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EDK40775.2 - 0.0054 15.6 6.0 0.0054 15.6 6.0 2.2 2 1 0 2 2 2 1 MFS_1 like family Sugar_tr PF00083.24 EDK40776.2 - 1.1e-82 278.4 16.3 1.2e-82 278.1 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40776.2 - 1.2e-26 93.5 37.1 3e-25 88.9 21.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK40776.2 - 1.8e-06 26.8 7.9 0.0011 17.6 0.9 2.6 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_4 PF06779.14 EDK40776.2 - 1.5e-05 24.5 3.7 1.5e-05 24.5 3.7 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 EDK40776.2 - 7e-05 21.9 3.3 7e-05 21.9 3.3 2.2 2 0 0 2 2 2 1 MFS_1 like family Pro_isomerase PF00160.21 EDK40777.1 - 1.5e-47 161.8 0.1 1.7e-47 161.7 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Redoxin PF08534.10 EDK40778.1 - 2.6e-27 95.3 0.1 3.1e-27 95.1 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDK40778.1 - 3e-05 23.9 0.0 4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Avl9 PF09794.9 EDK40779.2 - 3.9e-134 447.1 4.3 4.8e-134 446.8 4.3 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 EDK40779.2 - 5.5e-10 39.3 4.7 2.5e-09 37.1 4.7 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 EDK40779.2 - 6.5e-07 29.3 1.2 0.033 14.1 0.4 2.6 1 1 1 2 2 2 2 Stabilization of polarity axis DENN PF02141.21 EDK40779.2 - 5.6e-05 23.2 3.5 0.00025 21.0 3.1 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain WD40 PF00400.32 EDK40780.1 - 3.3e-06 27.7 0.1 0.15 13.0 0.2 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat Lactonase PF10282.9 EDK40780.1 - 0.0013 18.1 0.1 0.061 12.6 0.0 2.7 3 0 0 3 3 3 1 Lactonase, 7-bladed beta-propeller ABC_membrane PF00664.23 EDK40781.2 - 4.4e-82 275.8 29.8 9.6e-43 146.8 17.7 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDK40781.2 - 7.3e-47 159.3 0.1 5.3e-28 98.2 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDK40781.2 - 5.1e-08 32.6 7.8 0.0018 17.8 2.8 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDK40781.2 - 2e-05 24.6 2.0 0.1 12.7 0.2 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDK40781.2 - 0.00057 19.6 1.3 0.77 9.5 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK40781.2 - 0.00067 20.1 0.3 0.17 12.2 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 EDK40781.2 - 0.00078 19.2 0.5 0.091 12.4 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EDK40781.2 - 0.0017 18.3 0.6 0.65 9.9 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EDK40781.2 - 0.0029 17.5 1.6 1 9.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EDK40781.2 - 0.0037 17.4 0.7 1.5 8.8 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_30 PF13604.6 EDK40781.2 - 0.0038 17.0 0.4 1.8 8.3 0.3 2.9 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EDK40781.2 - 0.009 16.5 2.5 1.9 8.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain MeaB PF03308.16 EDK40781.2 - 0.034 13.1 0.1 0.092 11.7 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB UPF0093 PF03653.13 EDK40781.2 - 0.063 13.5 0.3 0.063 13.5 0.3 2.5 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0093) Dynamin_N PF00350.23 EDK40781.2 - 0.064 13.3 2.2 0.66 10.0 0.2 2.6 2 0 0 2 2 2 0 Dynamin family Zeta_toxin PF06414.12 EDK40781.2 - 0.11 11.8 0.1 8.9 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 EDK40781.2 - 0.15 12.3 1.5 27 5.0 0.0 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EDK40781.2 - 0.21 11.5 0.8 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 EDK40781.2 - 0.22 11.8 1.6 30 4.9 0.0 3.3 2 1 0 2 2 2 0 AAA domain Sec1 PF00995.23 EDK40782.2 - 1.1e-85 289.1 0.1 1.5e-85 288.6 0.1 1.1 1 0 0 1 1 1 1 Sec1 family TPT PF03151.16 EDK40783.2 - 2.8e-18 66.3 19.5 7.7e-18 64.8 19.5 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EDK40783.2 - 4.1e-10 39.3 18.3 6.2e-10 38.8 18.3 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDK40783.2 - 3.9e-07 30.3 16.2 3.9e-07 30.3 16.2 2.8 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 EDK40783.2 - 1.7e-06 27.5 17.1 2.5e-06 27.0 17.1 1.2 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport DUF3754 PF12576.8 EDK40783.2 - 0.9 9.5 4.3 3.4 7.6 0.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3754) Asp PF00026.23 EDK40784.2 - 1.5e-23 83.8 0.2 2.9e-23 82.8 0.2 1.5 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Melibiase_2 PF16499.5 EDK40785.2 - 1.1e-57 195.4 9.1 4.5e-57 193.4 9.1 1.9 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EDK40785.2 - 7.3e-08 32.4 0.3 1.3e-07 31.5 0.3 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EDK40785.2 - 1.2e-06 27.7 0.1 4.7e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Melibiase MFS_1 PF07690.16 EDK40786.2 - 6.1e-41 140.5 48.9 1.1e-39 136.4 46.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK40786.2 - 3e-15 55.7 28.4 4e-15 55.3 28.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EDK40786.2 - 1.2e-08 34.2 17.5 1.2e-08 34.2 17.5 3.1 2 2 1 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40787.2 - 9.9e-26 90.5 28.9 3.3e-14 52.6 12.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK40787.2 - 2.5e-07 29.6 25.5 3.9e-06 25.7 3.8 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.24 EDK40787.2 - 4.4e-05 22.5 17.2 0.00019 20.5 13.6 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EDK40787.2 - 0.0013 17.7 21.7 0.0019 17.1 6.4 2.3 1 1 1 2 2 2 2 MFS_1 like family MFS_1 PF07690.16 EDK40788.2 - 2.4e-30 105.6 42.3 2.4e-30 105.6 42.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Ferric_reduct PF01794.19 EDK40789.2 - 3.3e-19 69.2 2.1 3.3e-19 69.2 2.1 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EDK40789.2 - 3.6e-12 46.7 0.0 7.3e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDK40789.2 - 6.9e-10 39.0 0.0 1.6e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain DUF2157 PF09925.9 EDK40789.2 - 0.0061 16.4 1.1 0.066 13.0 0.8 2.4 2 2 0 2 2 2 1 Predicted membrane protein (DUF2157) Z1 PF10593.9 EDK40789.2 - 0.23 10.9 0.6 2.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Z1 domain DUF4405 PF14358.6 EDK40789.2 - 0.67 10.5 7.9 0.35 11.5 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Glyco_hydro_114 PF03537.13 EDK40790.2 - 2.4e-88 295.4 3.0 2.8e-88 295.1 3.0 1.0 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 DUF1148 PF06618.11 EDK40791.2 - 0.074 13.2 0.1 0.15 12.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1148) NAD_binding_10 PF13460.6 EDK40792.2 - 1.3e-09 38.2 0.0 2.2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK40792.2 - 2.1e-09 37.2 0.0 2.6e-05 23.8 0.1 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDK40792.2 - 1.7e-08 34.3 0.2 2.6e-08 33.7 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EDK40792.2 - 9.9e-08 31.5 0.1 1.5e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EDK40792.2 - 1.2e-05 25.7 0.1 2.1e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EDK40792.2 - 1.3e-05 24.6 0.1 2.4e-05 23.6 0.1 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EDK40792.2 - 0.00017 20.7 0.1 0.00059 18.9 0.1 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDK40792.2 - 0.0018 17.7 0.5 0.0031 17.0 0.1 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase DXP_reductoisom PF02670.16 EDK40792.2 - 0.0024 18.6 0.2 0.0054 17.4 0.2 1.7 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase AlaDh_PNT_C PF01262.21 EDK40792.2 - 0.0047 16.2 0.2 0.0074 15.6 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 EDK40792.2 - 0.0083 16.2 0.3 0.013 15.5 0.3 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EDK40792.2 - 0.0084 16.7 0.3 0.019 15.5 0.3 1.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 EDK40792.2 - 0.0089 16.1 0.1 0.015 15.5 0.1 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 EDK40792.2 - 0.024 14.1 0.2 0.041 13.3 0.2 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DUF2325 PF10087.9 EDK40792.2 - 0.097 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) GFO_IDH_MocA PF01408.22 EDK40792.2 - 0.13 13.1 0.0 0.23 12.3 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold RmlD_sub_bind PF04321.17 EDK40792.2 - 0.16 11.0 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Sugar_tr PF00083.24 EDK40793.1 - 5.5e-133 444.1 20.2 6.3e-133 443.9 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40793.1 - 2.8e-24 85.7 20.6 2.8e-24 85.7 20.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 EDK40793.1 - 2.8 7.8 6.2 0.4 10.5 0.3 2.6 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Epimerase PF01370.21 EDK40794.2 - 4.4e-20 72.2 0.0 6.1e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK40794.2 - 1.3e-14 53.9 0.0 1.7e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EDK40794.2 - 5.1e-09 36.0 0.0 6.9e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EDK40794.2 - 2.2e-08 34.2 0.0 3.7e-08 33.5 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK40794.2 - 3.4e-06 26.4 0.0 0.05 12.8 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein adh_short PF00106.25 EDK40794.2 - 3.4e-05 23.4 0.0 7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EDK40794.2 - 0.0032 17.1 0.1 0.0094 15.5 0.0 1.8 2 0 0 2 2 2 1 NmrA-like family MucBP_2 PF17965.1 EDK40794.2 - 0.01 16.4 0.4 7.3 7.3 0.0 3.6 3 1 0 3 3 3 0 Mucin binding domain adh_short_C2 PF13561.6 EDK40794.2 - 0.015 14.9 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DapB_N PF01113.20 EDK40794.2 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CRCB PF02537.15 EDK40795.2 - 2.6e-30 104.6 26.4 2.9e-20 72.4 8.8 2.6 3 0 0 3 3 3 2 CrcB-like protein, Camphor Resistance (CrcB) FMN_bind_2 PF04299.12 EDK40796.2 - 4.4e-62 208.7 0.3 5.8e-62 208.3 0.3 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain RRM_1 PF00076.22 EDK40797.1 - 6.5e-16 57.9 0.0 1.1e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDK40797.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Oxysterol_BP PF01237.18 EDK40797.1 - 0.35 9.6 2.8 0.5 9.2 2.8 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein Fasciclin PF02469.22 EDK40798.2 - 6.6e-21 74.9 1.9 1.1e-08 35.3 0.1 5.0 5 1 0 5 5 5 3 Fasciclin domain Aa_trans PF01490.18 EDK40799.2 - 1.3e-61 208.5 27.0 1.6e-61 208.2 27.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EamA PF00892.20 EDK40800.2 - 5.3e-12 46.1 34.2 1.5e-07 31.7 3.8 3.2 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 EDK40800.2 - 0.00067 19.0 10.3 0.0012 18.2 10.3 1.5 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 EDK40800.2 - 0.0043 16.6 14.5 0.0043 16.6 14.5 1.6 2 0 0 2 2 2 1 Solute carrier family 35 PepSY_TM PF03929.16 EDK40800.2 - 0.0048 16.6 1.7 0.011 15.5 1.7 1.5 1 0 0 1 1 1 1 PepSY-associated TM region DUF3955 PF13127.6 EDK40800.2 - 0.0075 16.1 2.8 0.0075 16.1 2.8 4.7 6 0 0 6 6 6 2 Protein of unknown function (DUF3955) DUF3180 PF11377.8 EDK40800.2 - 0.031 14.4 1.1 0.068 13.3 0.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3180) OST3_OST6 PF04756.13 EDK40801.2 - 2.9e-72 243.5 0.4 3.7e-72 243.1 0.4 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family UPF0016 PF01169.19 EDK40801.2 - 0.33 11.3 4.0 0.17 12.2 0.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 UDG PF03167.19 EDK40802.2 - 7.1e-17 61.8 0.0 1.3e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Mannosyl_trans3 PF11051.8 EDK40803.2 - 7.3e-80 268.2 0.0 1e-79 267.7 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative SNF2_N PF00176.23 EDK40804.2 - 9.9e-75 251.4 0.1 2.1e-74 250.4 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EDK40804.2 - 2.5e-37 127.4 0.5 2.5e-37 127.4 0.5 3.4 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 EDK40804.2 - 2.5e-34 118.4 4.6 2.5e-34 118.4 4.6 3.0 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 EDK40804.2 - 4.2e-19 68.9 0.0 2.2e-18 66.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK40804.2 - 3e-12 46.9 2.5 9.6e-12 45.2 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK40804.2 - 3.3e-07 29.8 1.2 5.5e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EDK40804.2 - 5.5e-05 22.9 0.3 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD PF00270.29 EDK40804.2 - 0.00049 19.9 0.0 0.0023 17.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 EDK40804.2 - 0.00063 19.9 0.0 0.0037 17.4 0.0 2.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 EDK40804.2 - 0.028 13.6 0.1 0.028 13.6 0.1 2.1 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase DOT1 PF08123.13 EDK40806.2 - 1.5e-69 233.6 0.1 4e-69 232.3 0.2 1.7 2 0 0 2 2 2 1 Histone methylation protein DOT1 YL1 PF05764.13 EDK40807.2 - 0.019 15.1 17.1 0.037 14.1 17.1 1.5 1 0 0 1 1 1 0 YL1 nuclear protein RTT107_BRCT_6 PF16771.5 EDK40807.2 - 0.096 12.8 1.8 1.1 9.5 0.8 2.6 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain CDC45 PF02724.14 EDK40807.2 - 0.3 9.4 16.2 0.48 8.7 16.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDK40807.2 - 0.32 9.2 21.7 0.51 8.5 21.7 1.2 1 0 0 1 1 1 0 Nop14-like family PALP PF00291.25 EDK40808.2 - 9.2e-57 192.7 0.1 1.1e-56 192.4 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rad33 PF08730.10 EDK40809.2 - 8.9e-62 207.9 0.0 1.1e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 Rad33 EMP24_GP25L PF01105.24 EDK40811.2 - 3.3e-43 147.7 0.3 4.3e-43 147.4 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DASH_Dad2 PF08654.10 EDK40811.2 - 0.013 15.9 0.2 0.02 15.3 0.2 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 Sec34 PF04136.15 EDK40811.2 - 0.076 12.9 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Sec34-like family M16C_assoc PF08367.11 EDK40812.2 - 1.7e-74 250.1 2.0 2.5e-74 249.6 2.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EDK40812.2 - 7.4e-06 26.1 0.1 0.027 14.5 0.0 2.4 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDK40813.2 - 1.5e-09 38.0 0.0 2.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Mito_carr PF00153.27 EDK40814.2 - 9.4e-55 182.5 5.2 6e-18 64.6 0.6 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-MYND PF01753.18 EDK40815.2 - 6.4e-07 29.3 19.3 1.5e-06 28.2 19.3 1.7 1 0 0 1 1 1 1 MYND finger Spt5_N PF11942.8 EDK40815.2 - 2.3 9.3 13.0 0.76 10.8 9.4 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF4611 PF15387.6 EDK40815.2 - 2.4 8.4 7.2 9.8 6.5 7.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Ribosomal_60s PF00428.19 EDK40815.2 - 3.6 8.3 7.0 24 5.6 1.4 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Say1_Mug180 PF10340.9 EDK40816.2 - 3.1e-24 85.5 0.6 1.7e-23 83.1 0.6 2.1 1 1 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDK40816.2 - 1.1e-15 58.1 0.0 1.5e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK40816.2 - 0.049 14.2 0.0 0.065 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2737 PF10930.8 EDK40817.2 - 0.18 11.4 13.0 1.3 8.6 9.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2737) Glyco_hydro_76 PF03663.14 EDK40818.2 - 3.3e-20 73.0 11.8 4e-20 72.7 11.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF240 PF03086.14 EDK40818.2 - 0.19 11.7 1.2 3.9 7.4 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF240) DUF2401 PF10287.9 EDK40819.2 - 4.2e-79 265.4 4.1 4.2e-79 265.4 4.1 1.6 2 0 0 2 2 2 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EDK40819.2 - 5.7e-23 81.1 0.1 1.1e-22 80.2 0.1 1.5 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) DUF2190 PF09956.9 EDK40819.2 - 0.76 10.3 0.1 0.76 10.3 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2190) DUF641 PF04859.12 EDK40820.2 - 0.0033 17.7 18.3 0.016 15.6 5.6 2.6 1 1 1 2 2 2 2 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 EDK40820.2 - 0.23 11.5 25.1 0.087 12.9 16.3 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 EDK40820.2 - 0.29 11.2 12.8 2.8 8.0 6.5 3.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3080 PF11279.8 EDK40820.2 - 0.3 10.3 11.7 0.24 10.6 10.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3080) CorA PF01544.18 EDK40820.2 - 0.41 9.9 4.7 0.83 8.9 4.4 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Occludin_ELL PF07303.13 EDK40820.2 - 0.41 11.4 21.4 0.37 11.5 3.9 3.4 2 1 1 3 3 3 0 Occludin homology domain Fez1 PF06818.15 EDK40820.2 - 0.45 11.0 27.1 0.33 11.4 7.3 2.4 1 1 1 2 2 2 0 Fez1 Fib_alpha PF08702.10 EDK40820.2 - 0.53 10.5 22.3 0.017 15.3 10.0 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 EDK40820.2 - 1.5 7.6 28.8 1.7 7.4 9.2 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EDK40820.2 - 1.9 8.6 29.5 0.023 14.8 11.7 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EDK40820.2 - 2.4 8.7 25.2 0.53 10.8 7.8 3.0 1 1 2 3 3 3 0 Apg6 coiled-coil region Tropomyosin PF00261.20 EDK40820.2 - 2.6 7.3 26.4 8.4 5.7 26.4 1.8 1 1 0 1 1 1 0 Tropomyosin DUF4407 PF14362.6 EDK40820.2 - 3.7 6.8 16.3 11 5.2 16.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2205 PF10224.9 EDK40820.2 - 4.3 7.4 12.8 7.8 6.6 0.2 3.3 1 1 2 3 3 3 0 Short coiled-coil protein Spectrin PF00435.21 EDK40820.2 - 6 7.4 16.0 7.8 7.0 2.5 2.9 1 1 2 3 3 3 0 Spectrin repeat NPV_P10 PF05531.12 EDK40820.2 - 8.1 7.0 11.9 18 5.9 0.5 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein KapB PF08810.10 EDK40820.2 - 8.7 6.6 9.8 3.3 7.9 3.7 3.0 1 1 3 4 4 4 0 Kinase associated protein B DUF745 PF05335.13 EDK40820.2 - 9.8 5.9 21.1 0.72 9.6 12.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Flavin_Reduct PF01613.18 EDK40821.1 - 5.7e-24 84.9 0.0 7.2e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Peptidase_C50 PF03568.17 EDK40822.2 - 5.5e-110 368.2 0.2 3.5e-109 365.5 0.0 2.4 2 0 0 2 2 2 1 Peptidase family C50 AAA_31 PF13614.6 EDK40822.2 - 0.0039 17.1 0.1 0.012 15.5 0.1 1.8 1 0 0 1 1 1 1 AAA domain Mpp10 PF04006.12 EDK40823.2 - 3.8e-123 412.1 63.0 7.6e-123 411.1 63.0 1.4 1 1 0 1 1 1 1 Mpp10 protein DUF1488 PF07369.11 EDK40823.2 - 0.048 13.7 1.8 0.72 9.9 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1488) FtsJ PF01728.19 EDK40824.2 - 1e-58 198.4 0.0 1.2e-58 198.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EDK40824.2 - 7.8e-07 29.0 0.0 5.1e-05 23.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK40824.2 - 0.0061 16.4 0.0 0.0087 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK40824.2 - 0.062 14.0 0.0 0.2 12.4 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain rRNA_methylase PF06962.12 EDK40824.2 - 0.12 12.3 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 Putative rRNA methylase PIR PF00399.19 EDK40825.1 - 3.2e-14 52.0 93.5 0.029 14.0 1.2 9.8 9 0 0 9 9 9 9 Yeast PIR protein repeat TFIIA PF03153.13 EDK40825.1 - 0.022 14.8 36.9 0.029 14.4 36.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RC-P840_PscD PF10657.9 EDK40825.1 - 0.038 14.1 5.8 0.74 9.9 0.3 3.4 1 1 3 4 4 4 0 Photosystem P840 reaction centre protein PscD Pirin PF02678.16 EDK40825.1 - 0.73 9.8 8.4 3.5 7.6 0.5 3.6 1 1 4 5 5 5 0 Pirin RRN3 PF05327.11 EDK40826.2 - 2.5e-178 594.1 13.7 3.6e-178 593.6 13.7 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Tristanin_u2 PF16638.5 EDK40826.2 - 8.5 7.2 7.3 2.2 9.1 0.2 2.5 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers JAB PF01398.21 EDK40827.2 - 0.0046 16.9 0.1 0.0079 16.2 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ACT_5 PF13710.6 EDK40827.2 - 0.032 14.1 0.6 2.4 8.1 0.0 2.7 3 0 0 3 3 3 0 ACT domain DUF1752 PF08550.10 EDK40829.2 - 3.6e-13 49.1 2.3 6.7e-13 48.2 2.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) STIMATE PF12400.8 EDK40830.2 - 2.5e-37 128.2 5.9 2.5e-37 128.2 5.9 1.5 2 0 0 2 2 2 1 STIMATE family ATP-synt_J PF04911.12 EDK40830.2 - 0.089 12.4 0.0 0.25 10.9 0.0 1.8 1 1 0 1 1 1 0 ATP synthase j chain COX17 PF05051.13 EDK40831.1 - 1.5e-22 79.6 7.1 1.7e-22 79.5 7.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EDK40831.1 - 6.9e-05 22.9 5.3 0.0001 22.3 5.3 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EDK40831.1 - 0.01 15.9 0.1 0.01 15.9 0.1 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Vps54 PF07928.12 EDK40832.2 - 9.5e-39 132.9 0.1 9.5e-39 132.9 0.1 3.2 3 0 0 3 3 3 1 Vps54-like protein DUF2312 PF10073.9 EDK40832.2 - 0.048 13.3 0.2 0.24 11.1 0.1 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Phage_TAC_7 PF10109.9 EDK40832.2 - 0.06 13.5 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, E, or 41 or 14 PhoU_div PF01865.16 EDK40832.2 - 0.071 12.4 1.8 0.29 10.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF47 COG2 PF06148.11 EDK40832.2 - 2.1 8.4 6.2 1.2 9.3 2.3 2.7 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 IF-2B PF01008.17 EDK40833.2 - 1.8e-57 194.7 0.1 2.7e-57 194.1 0.1 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family Pex2_Pex12 PF04757.14 EDK40834.2 - 1.9e-54 184.6 13.4 2.7e-54 184.1 13.4 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EDK40834.2 - 3.2e-06 27.2 2.4 6.1e-06 26.3 2.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EDK40834.2 - 3.1e-05 23.7 1.5 0.00025 20.8 1.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK40834.2 - 6.3e-05 22.8 1.1 0.00011 22.0 1.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK40834.2 - 0.00012 22.1 1.0 0.00025 21.0 1.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDK40834.2 - 0.0024 17.7 2.3 0.0046 16.8 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EDK40834.2 - 0.0075 16.1 0.1 3.8 7.4 0.1 2.6 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-RING_2 PF13639.6 EDK40834.2 - 0.0091 16.3 1.6 0.02 15.2 1.6 1.6 1 0 0 1 1 1 1 Ring finger domain Zn_Tnp_IS1595 PF12760.7 EDK40834.2 - 0.21 11.6 0.8 0.45 10.5 0.8 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PBP1_TM PF14812.6 EDK40834.2 - 0.29 11.5 1.0 0.61 10.5 0.2 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Not3 PF04065.15 EDK40835.2 - 1.4e-74 250.4 21.8 1.4e-74 250.4 21.8 1.5 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component Syntaxin-6_N PF09177.11 EDK40835.2 - 0.0017 18.9 7.8 0.081 13.5 0.5 2.6 2 0 0 2 2 2 2 Syntaxin 6, N-terminal NOT2_3_5 PF04153.18 EDK40835.2 - 0.0018 18.3 14.0 0.18 11.9 0.2 4.1 4 0 0 4 4 4 2 NOT2 / NOT3 / NOT5 family DivIC PF04977.15 EDK40835.2 - 0.36 10.6 8.2 1.6 8.5 1.6 3.3 3 1 0 3 3 3 0 Septum formation initiator Cep57_MT_bd PF06657.13 EDK40835.2 - 0.92 10.0 6.9 3.9 8.0 0.1 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 JIP_LZII PF16471.5 EDK40835.2 - 2.1 8.6 7.6 0.73 10.0 2.8 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Syntaxin_2 PF14523.6 EDK40835.2 - 8.3 6.9 10.4 1 9.8 0.4 3.0 2 1 1 3 3 3 0 Syntaxin-like protein HSP70 PF00012.20 EDK40836.2 - 2.2e-87 293.7 1.7 2.6e-87 293.4 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein DIOX_N PF14226.6 EDK40836.2 - 0.051 14.3 0.4 0.097 13.4 0.4 1.5 1 1 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal KIP1 PF07765.12 EDK40836.2 - 1.6 8.9 4.3 0.56 10.4 0.3 2.0 2 0 0 2 2 2 0 KIP1-like protein CotH PF08757.11 EDK40836.2 - 8.4 5.8 8.2 54 3.2 8.2 1.9 1 1 0 1 1 1 0 CotH kinase protein HSP70 PF00012.20 EDK40837.1 - 4.1e-75 253.2 0.7 4.9e-75 252.9 0.7 1.0 1 0 0 1 1 1 1 Hsp70 protein cNMP_binding PF00027.29 EDK40838.2 - 3.4e-40 136.0 0.2 1.2e-18 66.9 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EDK40838.2 - 2.8e-09 36.5 0.4 9.8e-09 34.7 0.3 2.0 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 EDK40838.2 - 0.19 11.4 1.6 3.4 7.5 0.5 2.5 2 0 0 2 2 2 0 Cupin domain Cupin_3 PF05899.12 EDK40838.2 - 0.58 9.9 2.3 1.4 8.7 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Hydrolase_4 PF12146.8 EDK40839.2 - 5.8e-16 58.5 0.0 9.1e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK40839.2 - 2.1e-14 54.7 0.0 3e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDK40839.2 - 5.7e-13 49.1 0.1 1e-12 48.2 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EDK40839.2 - 0.00049 19.7 0.1 0.0011 18.6 0.0 1.6 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DUF915 PF06028.11 EDK40839.2 - 0.0019 17.6 0.1 0.0049 16.2 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EDK40839.2 - 0.0022 17.8 0.1 0.0053 16.6 0.1 1.7 1 1 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.20 EDK40839.2 - 0.0035 17.5 0.1 0.0085 16.2 0.0 1.7 2 0 0 2 2 2 1 Thioesterase domain PGAP1 PF07819.13 EDK40839.2 - 0.0043 16.8 0.1 0.009 15.8 0.1 1.6 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EDK40839.2 - 0.0047 16.5 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 EDK40839.2 - 0.016 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Palm_thioest PF02089.15 EDK40839.2 - 0.041 13.7 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Ser_hydrolase PF06821.13 EDK40839.2 - 0.063 13.1 0.0 0.27 11.1 0.0 2.0 1 1 0 1 1 1 0 Serine hydrolase DUF900 PF05990.12 EDK40839.2 - 0.07 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Chlorophyllase2 PF12740.7 EDK40839.2 - 0.099 11.5 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme CN_hydrolase PF00795.22 EDK40840.2 - 1.9e-40 138.9 0.0 2.5e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EDK40840.2 - 7.2e-24 84.2 0.0 2.3e-23 82.6 0.0 1.7 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EDK40840.2 - 0.052 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Asparagine synthase TauD PF02668.16 EDK40841.2 - 1.2e-36 126.9 0.1 1.9e-36 126.2 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Erg28 PF03694.13 EDK40842.1 - 1.4e-47 160.6 1.5 1.7e-47 160.4 1.5 1.1 1 0 0 1 1 1 1 Erg28 like protein HRXXH PF13933.6 EDK40843.2 - 6.8e-109 363.1 2.6 1.1e-108 362.4 2.6 1.3 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.6 EDK40843.2 - 6.9e-07 29.9 0.2 6.9e-07 29.9 0.2 2.0 2 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase Ssl1 PF04056.14 EDK40844.2 - 3.6e-66 222.7 0.1 5.5e-66 222.1 0.1 1.3 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EDK40844.2 - 8.2e-23 80.4 14.0 9.9e-23 80.2 6.1 2.6 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EDK40844.2 - 9.3e-13 48.8 0.0 2.2e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EDK40844.2 - 0.00017 21.9 0.8 0.00028 21.2 0.5 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.21 EDK40844.2 - 0.091 13.0 14.1 0.1 12.9 7.5 2.8 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zinc_ribbon_15 PF17032.5 EDK40844.2 - 0.54 11.0 13.2 1.2 9.9 2.1 2.6 2 0 0 2 2 2 0 zinc-ribbon family DZR PF12773.7 EDK40844.2 - 1.8 8.7 17.4 0.49 10.5 2.1 3.0 1 1 1 2 2 2 0 Double zinc ribbon zf-HIT PF04438.16 EDK40844.2 - 7.5 6.5 22.7 1.6 8.7 4.2 3.9 4 0 0 4 4 4 0 HIT zinc finger Spt5-NGN PF03439.13 EDK40845.2 - 5.5e-23 80.7 0.0 1.1e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 EDK40845.2 - 1e-21 77.7 17.1 1e-21 77.7 17.1 3.4 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 EDK40845.2 - 9.9e-13 47.6 15.8 1.1e-06 28.4 0.4 6.1 6 0 0 6 6 6 3 KOW motif NusG PF02357.19 EDK40845.2 - 0.096 13.2 0.0 23 5.6 0.0 3.0 2 0 0 2 2 2 0 Transcription termination factor nusG MreC PF04085.14 EDK40845.2 - 0.61 10.0 5.9 0.27 11.1 0.2 2.6 3 0 0 3 3 3 0 rod shape-determining protein MreC YajC PF02699.15 EDK40845.2 - 3.2 7.7 6.5 1.5 8.7 0.3 3.2 4 0 0 4 4 4 0 Preprotein translocase subunit AA_permease PF00324.21 EDK40846.2 - 6.6e-93 311.9 41.8 8.1e-93 311.6 41.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK40846.2 - 2.4e-25 89.3 44.6 3.2e-25 88.8 44.6 1.1 1 0 0 1 1 1 1 Amino acid permease Pribosyltran PF00156.27 EDK40848.2 - 6.5e-15 55.0 0.0 7.8e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDK40848.2 - 0.0056 16.2 0.0 0.0073 15.8 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase HD PF01966.22 EDK40849.2 - 3.9e-07 30.3 0.0 5.8e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 HD domain Med13_N PF11597.8 EDK40850.2 - 8.9e-63 212.5 2.4 8.9e-63 212.5 2.4 1.9 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 EDK40850.2 - 5.8e-17 62.0 0.2 5.8e-17 62.0 0.2 4.1 4 1 0 4 4 4 1 Mediator complex subunit 13 C-terminal domain MFS_1 PF07690.16 EDK40851.2 - 1.8e-37 129.1 31.7 1.8e-37 129.1 31.7 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDK40851.2 - 6.1e-05 21.5 2.9 6.1e-05 21.5 2.9 2.0 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family PsbM PF05151.12 EDK40851.2 - 0.06 13.2 1.6 0.27 11.1 1.6 2.2 1 0 0 1 1 1 0 Photosystem II reaction centre M protein (PsbM) DUF1993 PF09351.10 EDK40852.2 - 6.2e-40 137.0 0.0 7e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) XFP_N PF09364.10 EDK40852.2 - 0.13 11.0 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 XFP N-terminal domain HALZ PF02183.18 EDK40853.2 - 0.0065 16.7 1.3 0.092 13.0 0.4 2.6 2 0 0 2 2 2 1 Homeobox associated leucine zipper TSC22 PF01166.18 EDK40853.2 - 0.013 15.8 6.6 1.6 9.1 0.3 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family Csm1_N PF18504.1 EDK40853.2 - 0.1 13.0 5.3 0.79 10.1 0.2 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1840 PF08895.11 EDK40853.2 - 0.25 11.7 2.1 0.97 9.8 2.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) NYD-SP28_assoc PF14775.6 EDK40853.2 - 0.44 10.7 3.2 0.47 10.6 0.5 2.4 2 0 0 2 2 2 0 Sperm tail C-terminal domain bZIP_1 PF00170.21 EDK40853.2 - 0.47 10.6 9.7 6.5 6.9 0.1 3.4 2 1 0 3 3 3 0 bZIP transcription factor GluR_Homer-bdg PF10606.9 EDK40853.2 - 4.6 7.5 9.2 1.7 8.9 0.6 3.9 4 0 0 4 4 4 0 Homer-binding domain of metabotropic glutamate receptor DUF4407 PF14362.6 EDK40853.2 - 7 5.9 8.0 13 5.0 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cyclin_N PF00134.23 EDK40854.2 - 8.1e-43 145.2 1.7 1.5e-41 141.1 0.6 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDK40854.2 - 1.5e-32 112.1 0.1 5.4e-32 110.4 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain NYD-SP28 PF14772.6 EDK40854.2 - 0.24 11.5 0.2 0.24 11.5 0.2 1.6 2 0 0 2 2 2 0 Sperm tail RTT107_BRCT_5 PF16770.5 EDK40855.2 - 4.8e-30 103.4 1.5 8.5e-25 86.5 0.4 4.1 5 0 0 5 5 5 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EDK40855.2 - 1.8e-20 73.1 1.5 4.2e-07 30.3 0.0 6.8 5 2 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDK40855.2 - 1e-19 70.3 5.9 9.8e-13 47.8 0.1 5.4 6 1 0 6 6 6 2 twin BRCT domain BRCT_2 PF16589.5 EDK40855.2 - 4.9e-18 65.3 0.0 0.00054 20.3 0.0 5.9 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_6 PF16771.5 EDK40855.2 - 5.1e-11 42.8 0.9 5.1e-11 42.8 0.9 3.4 3 1 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EDK40855.2 - 0.00017 21.8 1.2 0.24 11.7 0.0 3.5 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EDK40855.2 - 0.00039 20.4 0.1 0.34 11.0 0.0 4.1 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain DUF3684 PF12449.8 EDK40855.2 - 0.16 9.8 9.8 0.23 9.2 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) DUF3280 PF11684.8 EDK40855.2 - 0.3 11.5 1.4 0.9 10.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2380) ENTH PF01417.20 EDK40856.2 - 3e-40 137.1 0.0 4.9e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain UIM PF02809.20 EDK40856.2 - 6.5e-06 25.7 6.6 0.013 15.3 1.4 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif Med15 PF09606.10 EDK40856.2 - 0.081 11.6 58.4 0.11 11.2 58.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Spore_III_AF PF09581.10 EDK40856.2 - 5.7 6.9 9.9 13 5.8 9.9 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Neur_chan_memb PF02932.16 EDK40857.2 - 0.0045 17.1 1.9 0.0045 17.1 0.1 1.8 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region BUD22 PF09073.10 EDK40857.2 - 0.0089 15.4 9.8 0.017 14.5 9.8 1.5 1 0 0 1 1 1 1 BUD22 TFIIA PF03153.13 EDK40857.2 - 0.058 13.4 15.1 0.026 14.5 5.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Radial_spoke PF04712.12 EDK40857.2 - 0.13 11.1 12.1 0.26 10.2 12.1 1.4 1 0 0 1 1 1 0 Radial spokehead-like protein Sigma70_ner PF04546.13 EDK40857.2 - 0.33 10.8 13.3 0.65 9.9 13.3 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF913 PF06025.12 EDK40857.2 - 0.34 9.9 3.2 0.54 9.2 3.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 EDK40857.2 - 0.4 8.8 17.8 0.68 8.1 17.8 1.3 1 0 0 1 1 1 0 Nop14-like family CPSF100_C PF13299.6 EDK40857.2 - 0.41 10.8 5.3 0.93 9.6 5.3 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal zf-piccolo PF05715.13 EDK40857.2 - 0.47 10.6 5.1 7.2 6.8 0.3 2.5 2 0 0 2 2 2 0 Piccolo Zn-finger RXT2_N PF08595.11 EDK40857.2 - 0.55 10.2 6.2 1.7 8.7 6.2 1.9 1 0 0 1 1 1 0 RXT2-like, N-terminal RR_TM4-6 PF06459.12 EDK40857.2 - 0.62 9.9 11.6 1.2 8.9 11.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SDA1 PF05285.12 EDK40857.2 - 0.77 9.1 16.8 1.2 8.5 16.8 1.2 1 0 0 1 1 1 0 SDA1 SAPS PF04499.15 EDK40857.2 - 4.9 5.8 9.7 7 5.3 9.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Glyco_hydro_76 PF03663.14 EDK40858.2 - 8.6e-158 525.6 17.1 9.9e-158 525.4 17.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EDK40858.2 - 0.054 12.6 0.2 0.054 12.6 0.2 2.7 1 1 2 3 3 3 0 Glycosyl Hydrolase Family 88 PX PF00787.24 EDK40859.2 - 4.8e-15 55.5 0.9 4.8e-15 55.5 0.9 2.4 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 EDK40859.2 - 0.00034 20.3 5.4 0.0065 16.1 1.2 2.3 2 0 0 2 2 2 2 Vps5 C terminal like DNA_topoisoIV PF00521.20 EDK40859.2 - 0.0061 15.5 1.4 0.0061 15.5 1.4 2.1 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DUF1664 PF07889.12 EDK40859.2 - 0.0076 16.3 0.7 3.5 7.7 0.1 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) DUF2096 PF09869.9 EDK40859.2 - 0.026 14.6 1.0 0.06 13.4 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) CLZ PF16526.5 EDK40859.2 - 0.034 14.5 5.5 18 5.8 0.0 3.9 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SPA PF08616.10 EDK40859.2 - 0.067 13.1 0.0 0.26 11.2 0.0 1.9 1 1 0 2 2 2 0 Stabilization of polarity axis SesA PF17107.5 EDK40859.2 - 0.17 12.1 3.4 13 6.0 0.1 3.2 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RmuC PF02646.16 EDK40859.2 - 0.18 10.9 4.1 0.064 12.4 0.3 2.0 2 0 0 2 2 2 0 RmuC family Syntaxin PF00804.25 EDK40859.2 - 0.18 11.4 2.9 0.24 11.0 0.4 2.3 2 0 0 2 2 2 0 Syntaxin DUF16 PF01519.16 EDK40859.2 - 0.22 12.0 9.4 3.2 8.3 0.3 3.5 2 1 1 3 3 3 0 Protein of unknown function DUF16 Dynactin_p22 PF07426.11 EDK40859.2 - 0.92 9.3 10.0 5.6 6.8 0.7 3.5 3 0 0 3 3 3 0 Dynactin subunit p22 Tropomyosin_1 PF12718.7 EDK40859.2 - 1 9.5 9.4 1.5 9.0 0.2 3.3 4 0 0 4 4 4 0 Tropomyosin like NPV_P10 PF05531.12 EDK40859.2 - 1.6 9.2 9.0 5 7.7 0.6 3.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EDK40859.2 - 7.7 6.8 10.3 1.4 9.2 0.8 3.6 3 0 0 3 3 3 0 Haemolysin XhlA SIR2 PF02146.17 EDK40860.2 - 1.7e-57 194.2 0.0 9.6e-57 191.7 0.0 1.9 2 0 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.22 EDK40860.2 - 0.035 13.8 0.0 5.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 EDK40860.2 - 0.42 10.4 1.8 5.9 6.7 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF592) Lung_7-TM_R PF06814.13 EDK40861.2 - 3e-59 200.7 17.3 6.2e-59 199.7 17.3 1.5 1 0 0 1 1 1 1 Lung seven transmembrane receptor HRG PF16954.5 EDK40861.2 - 0.062 13.7 0.3 0.062 13.7 0.3 2.9 2 0 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene TMEM43 PF07787.12 EDK40861.2 - 5.3 6.3 7.7 14 5.0 7.7 1.7 1 0 0 1 1 1 0 Transmembrane protein 43 PCI PF01399.27 EDK40862.2 - 7.4e-08 32.8 1.4 1.3e-07 32.0 0.1 2.2 2 1 0 2 2 2 1 PCI domain Rpn9_C PF18261.1 EDK40862.2 - 7.7e-05 22.2 0.3 0.0002 20.9 0.3 1.8 1 0 0 1 1 1 1 Rpn9 C-terminal helix BORCS7 PF16088.5 EDK40862.2 - 0.1 12.9 0.5 0.3 11.3 0.1 2.0 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 PX PF00787.24 EDK40864.2 - 3e-22 78.7 0.0 5e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 PX domain Prok-RING_2 PF14445.6 EDK40864.2 - 0.088 13.0 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 Mannosyl_trans3 PF11051.8 EDK40865.2 - 9.1e-84 281.1 0.0 1.3e-83 280.6 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative TFIIIC_delta PF12657.7 EDK40866.2 - 3.8e-27 95.4 0.3 3.6e-26 92.2 0.0 2.9 2 2 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EDK40866.2 - 0.00011 22.1 0.1 0.00037 20.4 0.1 1.8 1 1 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex EI24 PF07264.11 EDK40867.2 - 1.5 9.0 13.6 26 5.0 13.6 2.2 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) PALP PF00291.25 EDK40868.2 - 2.4e-58 197.9 0.0 2.9e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 EDK40868.2 - 0.055 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Helicase_C_2 PF13307.6 EDK40869.2 - 1.7e-55 187.8 0.1 5.6e-55 186.1 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDK40869.2 - 2.5e-50 170.5 1.8 6e-50 169.3 1.8 1.7 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EDK40869.2 - 7.7e-07 29.3 0.1 0.005 16.9 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK40869.2 - 0.013 15.3 1.2 0.98 9.2 1.2 2.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase PhoH PF02562.16 EDK40869.2 - 0.036 13.5 0.1 5.5 6.4 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 EDK40869.2 - 0.099 12.9 0.1 1.7 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain 2OG-FeII_Oxy_3 PF13640.6 EDK40870.2 - 2.9e-10 40.9 0.0 4.7e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UspB PF10625.9 EDK40870.2 - 0.085 12.8 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) Nic96 PF04097.14 EDK40871.2 - 1.2e-191 638.4 0.7 1.5e-191 638.1 0.7 1.1 1 0 0 1 1 1 1 Nup93/Nic96 DUF3741 PF12552.8 EDK40871.2 - 0.014 15.3 0.0 0.048 13.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) DUF2802 PF10975.8 EDK40871.2 - 0.052 13.7 0.1 0.31 11.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) DUF2232 PF09991.9 EDK40871.2 - 0.072 12.3 0.5 0.16 11.1 0.4 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) SNAD1 PF18744.1 EDK40871.2 - 1.1 9.1 3.1 9.7 6.0 0.2 2.7 3 0 0 3 3 3 0 Secreted Novel AID/APOBEC-like Deaminase 1 AA_permease_2 PF13520.6 EDK40872.2 - 1.1e-49 169.5 50.1 1.3e-49 169.2 50.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK40872.2 - 1.3e-23 83.4 44.1 1.6e-23 83.1 44.1 1.0 1 0 0 1 1 1 1 Amino acid permease LNS2 PF08235.13 EDK40873.2 - 3.6e-95 317.8 0.0 5.4e-95 317.2 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EDK40873.2 - 1.4e-40 137.4 0.1 4.9e-40 135.6 0.0 2.0 2 0 0 2 2 2 1 lipin, N-terminal conserved region CNDH2_C PF16858.5 EDK40873.2 - 3.9 7.3 12.0 7.7 6.3 12.0 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Pox_F12L PF03337.13 EDK40874.2 - 0.07 11.3 0.2 0.085 11.0 0.2 1.1 1 0 0 1 1 1 0 Poxvirus F12L protein WHH PF14414.6 EDK40874.2 - 0.093 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH DUF3589 PF12141.8 EDK40876.2 - 7.8e-187 621.7 0.6 9.2e-187 621.5 0.6 1.0 1 0 0 1 1 1 1 Beta-mannosyltransferases DUF3589 PF12141.8 EDK40877.2 - 1.2e-197 657.4 0.1 2.3e-197 656.5 0.0 1.5 2 0 0 2 2 2 1 Beta-mannosyltransferases LPP20 PF02169.16 EDK40877.2 - 8.2 6.9 11.2 3.1 8.2 4.0 2.7 3 0 0 3 3 3 0 LPP20 lipoprotein RRM_1 PF00076.22 EDK40880.2 - 8.8e-13 47.9 0.4 1.5e-08 34.4 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_9 PF18444.1 EDK40880.2 - 0.0045 16.8 0.1 0.085 12.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 EDK40880.2 - 0.0074 16.1 0.0 0.023 14.5 0.0 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif SET_assoc PF11767.8 EDK40880.2 - 0.092 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 EDK40880.2 - 0.2 11.3 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_3 PF07859.13 EDK40881.2 - 1.8e-11 44.3 0.0 3.3e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDK40881.2 - 2.2e-07 30.6 0.1 1.6e-06 27.7 0.1 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EDK40881.2 - 0.00011 22.2 0.2 0.0013 18.7 0.2 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 EDK40881.2 - 0.00024 20.5 1.1 0.00029 20.3 0.3 1.7 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Say1_Mug180 PF10340.9 EDK40881.2 - 0.0017 17.3 0.0 0.015 14.1 0.0 2.0 2 0 0 2 2 2 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EDK40881.2 - 0.0019 17.5 0.0 0.018 14.3 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK40881.2 - 0.0024 18.5 0.0 0.0031 18.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EDK40881.2 - 0.0048 16.5 0.0 0.0077 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase DUF900 PF05990.12 EDK40881.2 - 0.024 14.2 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 EDK40881.2 - 0.029 14.3 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 EDK40881.2 - 0.036 13.8 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 EDK40881.2 - 0.05 13.2 0.0 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold FSH1 PF03959.13 EDK40881.2 - 0.077 12.6 0.0 0.13 11.9 0.0 1.3 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 EDK40881.2 - 0.13 11.8 0.0 1.2 8.6 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family eIF3g PF12353.8 EDK40882.1 - 9.3e-42 142.4 4.0 1.3e-41 141.9 4.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EDK40882.1 - 2.8e-13 49.5 0.0 5.4e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 EDK40882.1 - 0.052 13.9 0.5 0.17 12.2 0.1 2.0 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 RIG-I_C-RD PF11648.8 EDK40882.1 - 0.094 13.0 1.6 1.8 8.8 0.4 2.4 2 0 0 2 2 2 0 C-terminal domain of RIG-I Sua5_yciO_yrdC PF01300.18 EDK40882.1 - 0.11 12.0 0.0 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 Telomere recombination WD40 PF00400.32 EDK40883.2 - 3.2e-21 75.2 15.4 7.5e-06 26.6 0.0 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40883.2 - 1.3e-08 35.1 1.6 0.36 11.1 0.0 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDK40883.2 - 0.00032 20.1 0.3 0.031 13.6 0.0 3.3 3 1 0 4 4 4 1 WD40-like domain STAG PF08514.11 EDK40884.2 - 7.8e-32 109.5 0.1 4.3e-31 107.2 0.1 2.4 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.6 EDK40884.2 - 0.0012 19.2 0.0 0.015 15.6 0.0 2.8 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EDK40884.2 - 0.015 15.5 0.9 4.9 7.7 0.0 4.5 5 0 0 5 5 5 0 HEAT repeat DUF1980 PF09323.10 EDK40884.2 - 0.037 13.9 0.1 0.091 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PGA2 PF07543.12 EDK40884.2 - 0.49 10.4 7.8 0.17 11.9 1.4 2.5 2 0 0 2 2 2 0 Protein trafficking PGA2 SWIRM PF04433.17 EDK40885.2 - 1.5e-27 95.8 3.4 1.5e-27 95.7 0.3 2.5 2 1 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 EDK40885.2 - 4.6e-10 39.5 0.0 1.3e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 EDK40885.2 - 4.4e-06 26.6 8.6 9.3e-06 25.5 8.6 1.5 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 EDK40885.2 - 0.00023 21.3 0.2 0.0015 18.7 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 EDK40885.2 - 0.0012 18.7 3.3 0.0036 17.1 0.4 2.2 2 0 0 2 2 2 1 Zinc finger, ZZ type Myb_DNA-bind_4 PF13837.6 EDK40885.2 - 0.033 14.6 0.4 0.14 12.6 0.0 2.3 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain CorA PF01544.18 EDK40885.2 - 3.5 6.8 8.2 1.2 8.4 0.9 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FTR1 PF03239.14 EDK40886.1 - 2.6e-94 315.8 9.9 3.1e-94 315.6 9.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DSRB PF10781.9 EDK40886.1 - 0.085 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Dextransucrase DSRB UPF0697 PF15117.6 EDK40886.1 - 1.5 9.0 3.3 31 4.7 0.2 2.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0697 FAA_hydrolase PF01557.18 EDK40887.2 - 4.7e-48 163.7 0.0 6e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family dCMP_cyt_deam_1 PF00383.23 EDK40888.2 - 3.5e-26 91.0 0.6 5.4e-26 90.4 0.6 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDK40888.2 - 1.2e-13 51.0 0.0 3.2e-13 49.6 0.0 1.7 2 0 0 2 2 2 1 MafB19-like deaminase AAA_18 PF13238.6 EDK40888.2 - 0.0026 18.3 0.2 0.0088 16.6 0.2 1.9 1 1 0 1 1 1 1 AAA domain SNAD4 PF18750.1 EDK40888.2 - 0.087 12.9 0.3 0.19 11.8 0.3 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 CoaE PF01121.20 EDK40888.2 - 0.21 11.3 0.3 0.46 10.2 0.1 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase NPC1_N PF16414.5 EDK40889.2 - 6.8e-83 278.0 11.4 1.1e-82 277.2 11.4 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EDK40889.2 - 8.2e-69 232.6 22.7 4e-47 160.9 1.8 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 EDK40889.2 - 4.2e-47 159.8 9.5 4.2e-47 159.8 9.5 2.8 4 0 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EDK40889.2 - 6.4e-05 22.0 1.8 6.4e-05 22.0 1.8 2.8 2 1 0 2 2 2 1 MMPL family CD24 PF14984.6 EDK40889.2 - 0.068 13.4 0.4 0.22 11.7 0.4 1.8 1 0 0 1 1 1 0 CD24 protein AMPK1_CBM PF16561.5 EDK40890.2 - 5e-16 58.7 0.0 9.7e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EDK40890.2 - 0.0065 16.8 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) DNA_RNApol_7kD PF03604.13 EDK40891.1 - 1.3e-15 56.7 2.7 1.7e-15 56.3 2.7 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 EDK40891.1 - 0.00053 20.0 0.3 0.00053 20.0 0.3 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbon_6 PF10005.9 EDK40891.1 - 0.0035 18.0 0.7 0.0046 17.6 0.7 1.2 1 0 0 1 1 1 1 zinc-ribbon domain C1_1 PF00130.22 EDK40891.1 - 0.006 16.4 0.9 0.008 16.0 0.9 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EDK40891.1 - 0.01 15.8 0.3 0.014 15.3 0.3 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 EDK40891.1 - 0.013 15.6 2.3 0.032 14.4 2.3 1.6 1 1 0 1 1 1 0 Zinc ribbon domain FYDLN_acid PF09538.10 EDK40891.1 - 0.015 16.0 0.3 0.017 15.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DZR PF12773.7 EDK40891.1 - 0.019 15.0 2.0 0.12 12.4 1.8 1.8 1 1 1 2 2 2 0 Double zinc ribbon FYVE_2 PF02318.16 EDK40891.1 - 0.026 14.7 0.6 0.03 14.6 0.6 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger FYVE PF01363.21 EDK40891.1 - 0.034 14.3 1.5 0.044 13.9 1.5 1.2 1 0 0 1 1 1 0 FYVE zinc finger UPF0547 PF10571.9 EDK40891.1 - 0.042 14.0 0.9 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 TFIIS_C PF01096.18 EDK40891.1 - 0.073 12.9 1.7 2.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf_UBZ PF18439.1 EDK40891.1 - 0.078 12.6 1.0 7.1 6.3 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_5 PF13719.6 EDK40891.1 - 0.12 12.2 4.8 0.28 10.9 0.1 2.1 1 1 1 2 2 2 0 zinc-ribbon domain Zn_ribbon_recom PF13408.6 EDK40891.1 - 0.13 12.8 1.0 0.13 12.8 1.0 1.9 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_4 PF13717.6 EDK40891.1 - 0.16 11.9 4.9 4.4 7.3 4.9 2.2 1 1 0 1 1 1 0 zinc-ribbon domain PPR_2 PF13041.6 EDK40892.2 - 4.6e-05 23.5 0.1 0.00034 20.8 0.1 2.6 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 EDK40892.2 - 0.51 10.5 4.4 1.9 8.6 0.7 3.7 4 1 0 4 4 4 0 Pentatricopeptide repeat domain WSC PF01822.19 EDK40893.2 - 6.2e-10 39.1 8.9 6.2e-10 39.1 8.9 3.3 3 0 0 3 3 3 1 WSC domain TFIIA PF03153.13 EDK40893.2 - 0.92 9.4 23.8 1.7 8.5 23.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ole-e-6 PF09253.10 EDK40893.2 - 1.7 8.7 9.0 8.7 6.4 1.0 2.5 2 0 0 2 2 2 0 Pollen allergen ole e 6 PPI_Ypi1 PF07491.11 EDK40894.2 - 5.4e-25 87.0 11.8 1.3e-24 85.8 11.8 1.7 1 1 0 1 1 1 1 Protein phosphatase inhibitor zf-C2H2 PF00096.26 EDK40895.2 - 1.1e-08 35.1 16.2 0.00011 22.4 2.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK40895.2 - 9.3e-05 22.7 3.3 9.3e-05 22.7 3.3 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK40895.2 - 0.0018 18.9 2.3 0.0018 18.9 2.3 3.7 2 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK40895.2 - 0.0046 16.9 1.0 0.014 15.4 1.0 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 EDK40895.2 - 0.011 16.1 1.4 0.011 16.1 1.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK40895.2 - 0.081 13.2 0.3 0.081 13.2 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EDK40895.2 - 0.16 12.6 0.4 0.16 12.6 0.4 3.1 2 1 1 3 3 3 0 FOXP coiled-coil domain tRNA_Me_trans PF03054.16 EDK40897.2 - 4.1e-120 400.8 0.0 4.7e-120 400.6 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 EDK40897.2 - 2e-06 27.1 0.0 0.00024 20.3 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Asn_synthase PF00733.21 EDK40897.2 - 0.00089 19.0 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 EDK40897.2 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 PP-loop family QueC PF06508.13 EDK40897.2 - 0.0066 16.0 0.1 0.082 12.4 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 EDK40897.2 - 0.029 14.0 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Dynactin_p22 PF07426.11 EDK40898.2 - 6.6e-06 26.1 8.1 9.8e-06 25.5 8.1 1.3 1 0 0 1 1 1 1 Dynactin subunit p22 DUF4058 PF13267.6 EDK40898.2 - 0.014 14.8 1.3 0.029 13.8 1.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4058) DUF3573 PF12097.8 EDK40898.2 - 0.1 11.4 2.8 0.4 9.5 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) Lipid_DES PF08557.10 EDK40898.2 - 0.22 11.1 1.2 12 5.5 0.2 3.2 3 0 0 3 3 3 0 Sphingolipid Delta4-desaturase (DES) DUF5344 PF17279.2 EDK40898.2 - 0.4 11.3 4.8 3.7 8.2 0.0 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5344) FlxA PF14282.6 EDK40898.2 - 2.4 8.2 10.9 7.1 6.7 1.7 3.3 3 1 0 3 3 3 0 FlxA-like protein YabA PF06156.13 EDK40898.2 - 4.2 8.1 7.0 18 6.0 0.9 2.9 1 1 1 2 2 2 0 Initiation control protein YabA Pro_isomerase PF00160.21 EDK40899.2 - 6.8e-54 182.4 0.6 1.1e-53 181.8 0.6 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EDK40899.2 - 0.0003 21.5 0.0 32 5.6 0.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat Gmad1 PF10647.9 EDK40899.2 - 0.061 13.1 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain EAF PF09816.9 EDK40900.2 - 1.2e-08 35.2 0.3 3.2e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor SNase PF00565.17 EDK40901.1 - 1.1e-20 74.1 0.0 1.5e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue PGM_PMM_I PF02878.16 EDK40902.1 - 1.8e-17 63.3 0.0 3e-07 30.2 0.0 2.8 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EDK40902.1 - 5.9e-10 39.2 0.4 1.3e-09 38.1 0.4 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EDK40902.1 - 3.7e-08 33.9 0.5 3.3e-06 27.7 0.1 3.2 3 1 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EDK40902.1 - 0.011 15.9 0.1 0.032 14.4 0.1 1.9 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III RrnaAD PF00398.20 EDK40904.2 - 1.2e-69 234.3 0.0 1.8e-69 233.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EDK40904.2 - 8.9e-06 26.3 0.0 2.7e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK40904.2 - 0.00093 19.8 0.0 0.0027 18.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK40904.2 - 0.0063 17.2 0.0 0.015 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDK40904.2 - 0.011 15.0 0.0 0.03 13.6 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EDK40904.2 - 0.038 13.7 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 EDK40904.2 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_18 PF12847.7 EDK40904.2 - 0.14 12.0 0.0 7.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 EDK40904.2 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain KAR9 PF08580.10 EDK40905.2 - 7.7e-57 193.3 5.8 1.6e-56 192.3 5.7 1.4 1 1 0 1 1 1 1 Yeast cortical protein KAR9 TAN PF11640.8 EDK40905.2 - 0.0011 19.1 0.6 0.0023 18.1 0.6 1.5 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Cep57_MT_bd PF06657.13 EDK40905.2 - 0.21 12.1 2.3 0.35 11.3 0.8 2.2 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Bcr-Abl_Oligo PF09036.10 EDK40905.2 - 0.23 11.5 2.6 9 6.4 0.5 2.6 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Kelch_4 PF13418.6 EDK40906.2 - 5.2e-38 128.8 4.9 1.1e-07 31.8 0.0 7.1 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EDK40906.2 - 2.3e-32 110.7 0.7 1.1e-09 38.3 0.0 7.3 7 0 0 7 7 7 4 Galactose oxidase, central domain DUF4110 PF13422.6 EDK40906.2 - 3.7e-25 87.8 0.1 3.7e-25 87.8 0.1 4.4 4 2 1 5 5 5 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 EDK40906.2 - 4.4e-22 77.6 6.1 3e-05 24.2 0.1 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EDK40906.2 - 7.5e-22 76.9 2.7 0.0022 17.9 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 EDK40906.2 - 1.3e-12 47.1 5.3 0.0009 18.8 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EDK40906.2 - 2.2e-11 43.2 12.1 0.068 13.2 0.0 6.7 6 1 0 6 6 6 4 Kelch motif CPSF100_C PF13299.6 EDK40906.2 - 6.1 7.0 17.6 5.6 7.1 2.6 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal CAF1C_H4-bd PF12265.8 EDK40908.1 - 1.6e-15 57.1 0.0 4e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDK40908.1 - 9.3e-12 45.3 12.4 0.0038 18.0 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40908.1 - 4.4e-07 30.1 0.4 0.031 14.6 0.1 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SLAIN PF15301.6 EDK40908.1 - 0.017 14.4 0.4 0.034 13.4 0.4 1.4 1 0 0 1 1 1 0 SLAIN motif-containing family PRP1_N PF06424.12 EDK40909.2 - 8.3e-28 97.7 8.0 5.6e-26 91.7 8.0 3.0 1 1 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EDK40909.2 - 3.3e-26 89.7 3.1 0.0095 16.7 0.0 12.7 8 3 6 14 14 13 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDK40909.2 - 4.5e-20 71.9 0.0 9.5e-05 22.8 0.0 8.6 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDK40909.2 - 2.3e-12 46.4 0.7 5.5 7.6 0.0 10.0 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDK40909.2 - 1.5e-08 34.1 0.3 0.032 14.3 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDK40909.2 - 2e-07 30.5 14.5 0.0044 16.3 1.7 4.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDK40909.2 - 1.4e-06 27.9 0.0 0.49 10.3 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK40909.2 - 5.5e-05 23.5 6.9 17 6.3 0.0 7.0 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDK40909.2 - 0.00014 21.4 0.0 5.7 6.7 0.0 5.1 6 0 0 6 6 6 1 TPR repeat TPR_8 PF13181.6 EDK40909.2 - 0.00048 20.1 0.0 5 7.6 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDK40909.2 - 0.00067 20.3 0.1 3.3 8.4 0.0 4.4 4 1 2 6 6 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK40909.2 - 0.00091 19.5 3.8 0.081 13.2 0.0 4.8 7 0 0 7 7 7 1 Tetratricopeptide repeat Dynamin_N PF00350.23 EDK40909.2 - 0.043 13.9 0.7 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Dynamin family Fer4_13 PF13370.6 EDK40909.2 - 0.055 14.0 0.0 8.7 7.0 0.0 3.5 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I ANAPC3 PF12895.7 EDK40909.2 - 0.11 12.7 1.3 2.9 8.2 0.0 3.1 3 0 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Bac_rhamnosid6H PF17389.2 EDK40909.2 - 0.37 10.0 3.0 0.44 9.7 0.5 2.1 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF4995 PF16386.5 EDK40909.2 - 1.1 9.3 4.2 12 6.0 0.2 3.9 3 1 1 4 4 4 0 Domain of unknown function MAD PF05557.13 EDK40910.2 - 1.1e-33 116.5 70.2 9e-32 110.3 70.2 2.9 1 1 0 1 1 1 1 Mitotic checkpoint protein bZIP_1 PF00170.21 EDK40910.2 - 0.00071 19.6 3.8 0.013 15.6 0.6 10.0 8 4 5 13 13 13 3 bZIP transcription factor AbiEi_3_N PF17194.4 EDK40910.2 - 0.018 15.0 0.5 0.075 13.1 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain PAS_9 PF13426.7 EDK40910.2 - 0.24 11.7 1.0 1.9 8.8 0.1 3.0 2 1 1 3 3 3 0 PAS domain Filament PF00038.21 EDK40910.2 - 0.59 9.7 67.8 0.12 11.9 11.6 4.1 2 1 2 4 4 4 0 Intermediate filament protein Ribosomal_S15 PF00312.22 EDK40910.2 - 0.62 10.3 10.4 0.089 13.0 0.6 3.7 4 0 0 4 4 4 0 Ribosomal protein S15 WD40_alt PF14077.6 EDK40910.2 - 0.79 9.6 12.0 1.3 8.9 0.5 3.9 4 0 0 4 4 4 0 Alternative WD40 repeat motif GAS PF13851.6 EDK40910.2 - 1.1 8.6 77.3 0.09 12.1 13.7 5.2 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 EDK40910.2 - 1.2 9.2 74.4 0.029 14.5 2.4 7.1 3 2 3 6 6 6 0 Tropomyosin like BRI3BP PF14965.6 EDK40910.2 - 1.6 8.2 6.7 4 6.9 0.2 3.3 3 0 0 3 3 3 0 Negative regulator of p53/TP53 UQ_con PF00179.26 EDK40911.2 - 2e-19 69.7 0.1 2.2e-19 69.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDK40911.2 - 0.019 15.2 0.0 0.022 15.1 0.0 1.2 1 0 0 1 1 1 0 RWD domain Mitochondr_Som1 PF11093.8 EDK40912.2 - 4.2e-25 87.6 0.6 7.4e-25 86.8 0.6 1.4 1 0 0 1 1 1 1 Mitochondrial export protein Som1 MBOAT PF03062.19 EDK40913.2 - 7.6e-62 209.7 21.2 7.6e-62 209.7 21.2 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Sec7 PF01369.20 EDK40914.2 - 7.8e-24 84.4 1.5 3.1e-23 82.4 1.5 2.0 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EDK40914.2 - 0.0024 18.2 0.4 0.011 16.1 0.1 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain Proteasome PF00227.26 EDK40915.2 - 5.8e-43 146.6 0.0 7e-43 146.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cmc1 PF08583.10 EDK40916.2 - 1.5e-17 63.4 8.8 2.6e-17 62.6 8.8 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EDK40916.2 - 0.098 12.7 3.0 0.42 10.7 2.7 2.1 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3128 PF11326.8 EDK40916.2 - 9.7 6.6 10.9 57 4.2 10.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Peptidase_S10 PF00450.22 EDK40917.2 - 1.7e-130 436.2 0.2 2.1e-130 435.9 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EDK40917.2 - 9.2e-28 97.3 0.4 1.5e-27 96.6 0.4 1.3 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Otopetrin PF03189.13 EDK40918.2 - 0.0044 15.9 0.0 0.0064 15.4 0.0 1.3 1 0 0 1 1 1 1 Otopetrin rRNA_proc-arch PF13234.6 EDK40919.2 - 1.8e-83 280.6 0.8 1.8e-83 280.6 0.8 1.8 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 EDK40919.2 - 7.7e-58 194.8 1.7 2e-57 193.4 1.7 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EDK40919.2 - 4.6e-18 65.6 1.2 2.1e-17 63.4 0.0 2.8 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK40919.2 - 2.7e-07 30.9 0.0 1.1e-06 29.0 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK40919.2 - 0.0019 18.3 0.0 0.0086 16.1 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDK40919.2 - 0.039 14.2 0.1 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDK40919.2 - 0.039 13.0 0.0 0.12 11.4 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Glyco_hydro_20 PF00728.22 EDK40920.2 - 4.8e-92 309.1 1.7 6e-92 308.7 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EDK40920.2 - 1.1e-14 55.2 0.0 4.7e-14 53.2 0.0 2.1 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EDK40920.2 - 0.00057 20.7 0.0 0.00096 19.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF1624 PF07786.12 EDK40922.2 - 0.00082 19.0 0.8 0.0017 18.0 0.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1624) Sugar_tr PF00083.24 EDK40923.2 - 4.2e-77 259.9 29.3 4.8e-77 259.7 29.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40923.2 - 6.7e-12 45.0 32.5 8.6e-12 44.6 30.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily PITH PF06201.13 EDK40924.2 - 1.9e-34 119.1 0.0 2.3e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 PITH domain Bac_chlorC PF02043.17 EDK40925.2 - 0.072 13.1 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein His_Phos_1 PF00300.22 EDK40926.1 - 6.1e-37 127.2 0.1 1.7e-29 102.9 0.1 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) CC2D2AN-C2 PF15625.6 EDK40927.2 - 0.15 11.8 1.8 0.2 11.4 1.8 1.2 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain DUF5367 PF17329.2 EDK40929.2 - 0.98 9.6 6.7 5.3 7.2 0.3 4.2 5 0 0 5 5 5 0 Family of unknown function (DUF5367) Nsp1_C PF05064.13 EDK40930.2 - 4.5e-33 113.5 5.4 4.5e-33 113.5 5.4 1.8 2 0 0 2 2 2 1 Nsp1-like C-terminal region AAA_13 PF13166.6 EDK40930.2 - 0.022 13.4 0.6 0.039 12.6 0.3 1.5 1 1 1 2 2 2 0 AAA domain CorA PF01544.18 EDK40930.2 - 0.058 12.7 3.7 0.38 10.0 0.7 2.4 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Yqai PF09466.10 EDK40930.2 - 0.068 13.5 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 Hypothetical protein Yqai Bul1_C PF04426.12 EDK40930.2 - 0.14 11.5 1.8 0.15 11.4 0.3 1.8 2 0 0 2 2 2 0 Bul1 C terminus PMC2NT PF08066.12 EDK40930.2 - 0.2 12.4 3.8 0.43 11.3 0.8 2.2 2 0 0 2 2 2 0 PMC2NT (NUC016) domain NPV_P10 PF05531.12 EDK40930.2 - 0.34 11.4 6.1 0.36 11.3 0.2 3.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EDK40930.2 - 0.46 11.0 11.7 0.041 14.4 3.2 2.5 2 1 0 2 2 2 0 Apg6 coiled-coil region Phage_GP20 PF06810.11 EDK40930.2 - 1.4 8.7 9.9 1.2 8.9 2.3 2.5 2 1 0 2 2 2 0 Phage minor structural protein GP20 PQ-loop PF04193.14 EDK40931.2 - 6.1e-20 70.8 2.4 5.2e-12 45.3 0.0 3.2 2 1 0 2 2 2 2 PQ loop repeat Gemini_AL3 PF01407.17 EDK40931.2 - 0.064 13.1 0.2 5 7.0 0.0 2.3 2 0 0 2 2 2 0 Geminivirus AL3 protein ALAD PF00490.21 EDK40932.2 - 9e-116 386.5 0.0 1.1e-115 386.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Snf7 PF03357.21 EDK40933.2 - 2.4e-32 111.9 13.5 3.8e-32 111.3 13.5 1.3 1 0 0 1 1 1 1 Snf7 GrpE PF01025.19 EDK40933.2 - 1.3 8.6 11.7 0.077 12.7 3.6 2.2 2 0 0 2 2 2 0 GrpE WD40 PF00400.32 EDK40934.2 - 3.2e-15 56.2 12.2 0.0024 18.6 0.1 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK40934.2 - 1.7e-12 47.5 2.4 1.7e-05 25.0 0.3 3.6 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDK40934.2 - 0.00032 19.8 0.2 0.0078 15.2 0.1 2.9 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK40934.2 - 0.0012 18.8 0.5 1.4 8.8 0.1 2.9 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDK40934.2 - 0.0031 16.2 1.4 1.4 7.4 0.0 3.2 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Pkinase PF00069.25 EDK40935.1 - 1.2e-67 228.1 0.0 1.8e-67 227.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK40935.1 - 3.3e-31 108.5 0.0 5.2e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK40935.1 - 1.9e-05 23.8 0.1 2.8e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDK40935.1 - 0.00049 20.1 0.1 0.003 17.5 0.0 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EDK40935.1 - 0.0007 19.0 0.2 0.005 16.2 0.2 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDK40935.1 - 0.0009 18.6 0.0 0.013 14.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDK40935.1 - 0.009 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDK40935.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Rgp1 PF08737.10 EDK40936.2 - 2.5e-24 86.2 3.3 1.1e-21 77.5 0.5 3.2 2 1 0 2 2 2 2 Rgp1 Arrestin_C PF02752.22 EDK40936.2 - 0.0012 19.2 0.3 0.0065 16.9 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain A_deaminase PF00962.22 EDK40937.2 - 1e-124 416.1 0.0 1.5e-124 415.6 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Phos_pyr_kin PF08543.12 EDK40938.2 - 9.1e-65 218.4 0.0 1.6e-64 217.6 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EDK40938.2 - 1.1e-32 113.5 0.4 1.7e-32 112.9 0.4 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EDK40938.2 - 0.0048 16.2 0.0 0.011 15.1 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 EDK40938.2 - 0.039 13.3 0.2 0.26 10.6 0.2 2.0 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family EF-hand_4 PF12763.7 EDK40939.2 - 3.7e-23 81.4 0.0 2.5e-14 53.1 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 EDK40939.2 - 5.8e-18 65.1 210.0 1.4e-05 25.4 21.4 9.0 4 2 2 6 6 6 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EDK40939.2 - 6.3e-08 31.6 0.2 0.002 17.5 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 EDK40939.2 - 0.00014 22.2 0.0 0.19 12.2 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair WH2 PF02205.20 EDK40939.2 - 0.00015 21.4 0.3 0.0004 20.1 0.3 1.7 1 0 0 1 1 1 1 WH2 motif EF-hand_6 PF13405.6 EDK40939.2 - 0.001 18.8 0.9 3.2 7.9 0.1 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.6 EDK40939.2 - 0.003 17.4 0.0 0.5 10.2 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain pair DUF3287 PF11690.8 EDK40939.2 - 0.25 11.1 1.5 1.3 8.7 1.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) AAA_2 PF07724.14 EDK40940.2 - 3.5e-51 173.7 0.5 9.5e-50 169.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDK40940.2 - 5e-35 119.6 1.2 5e-35 119.6 1.2 2.7 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EDK40940.2 - 1.2e-24 86.2 1.7 3.7e-24 84.6 0.8 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDK40940.2 - 6.8e-20 71.8 0.2 3.1e-10 40.6 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK40940.2 - 1.3e-17 64.1 0.2 4.1e-11 43.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDK40940.2 - 1.8e-13 51.2 1.5 0.00028 21.3 0.1 4.7 3 1 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EDK40940.2 - 1.2e-09 38.6 2.4 0.00039 20.7 0.1 4.0 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 EDK40940.2 - 3.8e-08 33.2 0.1 4.3e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 EDK40940.2 - 1.7e-07 31.0 0.1 0.014 14.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EDK40940.2 - 3.8e-07 30.2 1.1 0.029 14.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EDK40940.2 - 2e-05 24.4 0.0 0.042 13.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.12 EDK40940.2 - 3.4e-05 23.8 0.1 0.33 10.8 0.0 3.3 3 0 0 3 3 3 2 NACHT domain ATPase_2 PF01637.18 EDK40940.2 - 4.9e-05 23.4 11.3 0.39 10.6 0.2 4.3 3 2 2 5 5 4 2 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDK40940.2 - 9e-05 22.8 0.7 0.74 10.2 0.0 3.3 3 1 0 3 3 2 2 RNA helicase TniB PF05621.11 EDK40940.2 - 0.0001 21.8 0.1 0.032 13.6 0.1 3.4 2 1 0 2 2 2 1 Bacterial TniB protein AAA_28 PF13521.6 EDK40940.2 - 0.00012 22.3 3.3 0.69 10.1 0.0 4.4 5 1 0 5 5 3 2 AAA domain ResIII PF04851.15 EDK40940.2 - 0.00015 21.8 0.4 1.4 8.9 0.0 3.4 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DUF815 PF05673.13 EDK40940.2 - 0.00022 20.5 1.0 0.045 12.9 0.4 3.6 2 2 0 2 2 2 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 EDK40940.2 - 0.00024 20.9 3.2 0.13 12.0 0.2 3.6 3 1 0 4 4 4 1 AAA domain AAA_18 PF13238.6 EDK40940.2 - 0.00037 21.0 2.3 0.61 10.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 EDK40940.2 - 0.00062 19.8 0.0 1.8 8.6 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EDK40940.2 - 0.00089 18.6 0.0 0.089 12.1 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin PhoH PF02562.16 EDK40940.2 - 0.0025 17.3 0.1 1.7 8.1 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA_6 PF12774.7 EDK40940.2 - 0.0027 16.8 0.0 0.073 12.0 0.0 2.3 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region Mg_chelatase PF01078.21 EDK40940.2 - 0.0027 17.1 0.1 2.2 7.6 0.0 3.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.9 EDK40940.2 - 0.0029 16.6 0.4 0.25 10.2 0.2 2.8 2 1 1 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain Torsin PF06309.11 EDK40940.2 - 0.0054 16.8 0.0 0.11 12.6 0.0 2.4 2 0 0 2 2 2 1 Torsin Roc PF08477.13 EDK40940.2 - 0.007 16.6 0.1 3.4 7.9 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EDK40940.2 - 0.01 15.6 0.1 4.9 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain PG_binding_3 PF09374.10 EDK40940.2 - 0.013 15.8 0.0 0.76 10.1 0.0 2.6 2 0 0 2 2 2 0 Predicted Peptidoglycan domain PduV-EutP PF10662.9 EDK40940.2 - 0.013 15.2 0.0 1.5 8.6 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 EDK40940.2 - 0.015 14.4 0.4 0.32 10.0 0.0 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF87 PF01935.17 EDK40940.2 - 0.019 15.1 9.8 0.55 10.3 0.0 3.6 3 1 0 3 3 2 0 Helicase HerA, central domain AAA_33 PF13671.6 EDK40940.2 - 0.02 15.1 0.1 6.6 6.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain NYD-SP28 PF14772.6 EDK40940.2 - 0.021 14.9 9.9 0.067 13.3 9.9 1.9 1 0 0 1 1 1 0 Sperm tail SRP54 PF00448.22 EDK40940.2 - 0.021 14.5 2.3 2.3 7.8 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 EDK40940.2 - 0.025 14.5 0.1 9.2 6.1 0.0 2.8 2 0 0 2 2 2 0 RsgA GTPase AAA_19 PF13245.6 EDK40940.2 - 0.037 14.4 6.8 0.76 10.1 0.1 3.9 4 1 1 5 5 3 0 AAA domain AAA_21 PF13304.6 EDK40940.2 - 0.044 13.6 2.3 5.9 6.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Muted PF14942.6 EDK40940.2 - 0.046 14.1 9.0 0.17 12.2 9.0 1.9 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein AAA_25 PF13481.6 EDK40940.2 - 0.097 12.2 0.0 12 5.4 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 EDK40940.2 - 0.11 12.3 0.1 2 8.3 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Seryl_tRNA_N PF02403.22 EDK40940.2 - 0.19 12.0 10.6 0.32 11.2 8.0 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ABC_tran PF00005.27 EDK40940.2 - 0.21 12.1 6.1 1.1 9.8 0.0 3.5 3 2 0 3 3 2 0 ABC transporter YlqD PF11068.8 EDK40940.2 - 0.34 11.3 9.1 1.3 9.4 9.1 2.1 1 0 0 1 1 1 0 YlqD protein DivIC PF04977.15 EDK40940.2 - 0.55 10.0 13.7 1.1 9.0 5.9 2.9 1 1 1 2 2 2 0 Septum formation initiator AAA_23 PF13476.6 EDK40940.2 - 3.5 8.1 23.7 10 6.6 0.0 3.6 2 1 0 2 2 1 0 AAA domain DUF4337 PF14235.6 EDK40940.2 - 6.5 6.9 6.2 22 5.1 5.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) PalH PF08733.10 EDK40941.2 - 5.4e-69 232.7 11.4 7e-69 232.3 11.4 1.0 1 0 0 1 1 1 1 PalH/RIM21 Dimer_Tnp_hAT PF05699.14 EDK40941.2 - 0.18 11.6 1.7 6.6 6.6 0.1 2.6 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Sec23_trunk PF04811.15 EDK40942.2 - 2.6e-43 148.4 0.0 4.5e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDK40942.2 - 4.6e-21 74.6 0.5 1.8e-20 72.7 0.3 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDK40942.2 - 7.5e-17 61.9 0.0 1.5e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDK40942.2 - 1.4e-10 41.1 9.3 3.4e-10 39.8 9.3 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger DUF508 PF04370.12 EDK40942.2 - 0.077 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Gelsolin PF00626.22 EDK40942.2 - 0.16 11.9 0.0 0.44 10.5 0.0 1.9 1 0 0 1 1 1 0 Gelsolin repeat UNC45-central PF11701.8 EDK40943.2 - 5.2e-24 84.9 14.9 6.7e-24 84.6 0.2 4.9 5 1 0 5 5 5 2 Myosin-binding striated muscle assembly central PUL PF08324.11 EDK40943.2 - 0.00065 19.0 3.2 0.005 16.1 0.7 2.9 3 0 0 3 3 3 1 PUL domain Arm PF00514.23 EDK40943.2 - 0.012 15.6 2.2 6.5 6.9 0.1 4.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat ING PF12998.7 EDK40944.1 - 1.6e-23 83.2 6.7 2.5e-23 82.6 6.7 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDK40944.1 - 1.7e-06 27.8 8.0 2.7e-06 27.1 8.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EDK40944.1 - 0.009 16.2 1.6 0.014 15.7 0.2 2.0 2 0 0 2 2 2 1 PHD-like zinc-binding domain JAKMIP_CC3 PF16034.5 EDK40944.1 - 0.019 14.9 3.7 0.042 13.8 3.7 1.5 1 0 0 1 1 1 0 JAKMIP CC3 domain PHD_2 PF13831.6 EDK40944.1 - 0.044 13.3 2.8 0.079 12.5 2.8 1.5 1 0 0 1 1 1 0 PHD-finger DUF5345 PF17280.2 EDK40944.1 - 0.25 11.3 0.1 0.25 11.3 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Mgr1 PF08602.10 EDK40946.2 - 7.9e-25 87.5 3.3 7.7e-15 54.6 0.0 3.1 1 1 2 3 3 3 3 Mgr1-like, i-AAA protease complex subunit bZIP_1 PF00170.21 EDK40947.2 - 2.1e-08 34.1 11.3 7.5e-08 32.4 10.9 2.0 1 1 0 1 1 1 1 bZIP transcription factor Shugoshin_N PF07558.11 EDK40947.2 - 0.021 14.7 1.0 0.064 13.1 1.0 1.8 1 1 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Tup_N PF08581.10 EDK40947.2 - 0.022 15.1 1.6 0.046 14.0 1.6 1.5 1 0 0 1 1 1 0 Tup N-terminal CASP_C PF08172.12 EDK40947.2 - 0.028 13.8 8.4 0.064 12.6 8.2 1.6 1 1 0 1 1 1 0 CASP C terminal Glutaredoxin2_C PF04399.13 EDK40947.2 - 0.038 13.8 0.7 0.065 13.1 0.7 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Phage_GP20 PF06810.11 EDK40947.2 - 0.048 13.5 5.4 0.11 12.4 5.4 1.5 1 1 0 1 1 1 0 Phage minor structural protein GP20 PRKG1_interact PF15898.5 EDK40947.2 - 0.05 14.5 6.9 0.078 13.9 6.9 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain SHE3 PF17078.5 EDK40947.2 - 0.071 12.8 3.6 0.091 12.5 3.1 1.4 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Atg14 PF10186.9 EDK40947.2 - 0.25 10.4 8.1 0.33 10.0 8.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 EDK40947.2 - 0.31 11.1 4.9 0.44 10.6 4.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus tRNA_bind_2 PF13725.6 EDK40947.2 - 0.32 10.7 5.0 0.49 10.1 5.0 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain bZIP_2 PF07716.15 EDK40947.2 - 0.46 10.6 14.0 30 4.8 14.0 2.4 1 1 0 1 1 1 0 Basic region leucine zipper DUF4407 PF14362.6 EDK40947.2 - 3.2 7.0 9.0 4.4 6.6 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spermine_synth PF01564.17 EDK40949.2 - 3e-74 248.5 0.0 1e-73 246.7 0.0 1.8 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDK40949.2 - 1.1e-22 79.7 0.1 2.3e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EDK40949.2 - 0.00036 21.2 0.0 0.00085 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK40949.2 - 0.00095 19.9 0.1 0.0029 18.3 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK40949.2 - 0.0014 18.4 0.0 0.0033 17.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 EDK40949.2 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 EDK40949.2 - 0.12 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 EDK40949.2 - 0.13 12.2 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Pfk_N PF18468.1 EDK40949.2 - 0.15 12.5 0.7 3 8.3 0.1 2.8 3 0 0 3 3 3 0 Phosphofructokinase N-terminal domain yeast MFS_1 PF07690.16 EDK40950.2 - 1.6e-31 109.6 38.4 1.6e-31 109.6 38.4 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EDK40951.2 - 1e-15 57.5 22.8 1.4e-15 57.1 22.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily V_ATPase_I PF01496.19 EDK40951.2 - 0.0016 16.5 0.3 0.0028 15.7 0.0 1.5 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family MFS_1 PF07690.16 EDK40952.2 - 1.5e-15 57.0 22.3 1.5e-15 57.0 22.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily V_ATPase_I PF01496.19 EDK40952.2 - 0.0053 14.8 0.0 0.0084 14.1 0.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Skp1 PF01466.19 EDK40952.2 - 0.41 10.8 1.3 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, dimerisation domain MIF4G PF02854.19 EDK40954.2 - 2.2e-19 69.9 11.1 1.9e-09 37.5 0.9 3.8 3 0 0 3 3 3 3 MIF4G domain SDA1 PF05285.12 EDK40954.2 - 0.1 12.0 30.7 0.24 10.8 30.7 1.6 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EDK40954.2 - 0.21 9.7 39.7 0.49 8.5 39.7 1.5 1 0 0 1 1 1 0 Nop14-like family NPAT_C PF15712.5 EDK40954.2 - 5.1 5.6 15.2 8.7 4.8 15.2 1.3 1 0 0 1 1 1 0 NPAT C terminus ATP-synt_E PF05680.12 EDK40955.2 - 4.9e-23 81.3 0.2 6.3e-23 80.9 0.2 1.1 1 0 0 1 1 1 1 ATP synthase E chain SpoIIE PF07228.12 EDK40956.2 - 6.3e-24 85.0 0.0 1e-23 84.3 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EDK40956.2 - 1.7e-06 27.9 0.0 2.2e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EDK40956.2 - 5.8e-06 26.1 0.0 9.9e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C FYVE PF01363.21 EDK40957.2 - 3.4e-19 68.7 24.5 1.7e-17 63.3 3.4 3.1 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EDK40957.2 - 1.7e-14 53.2 0.6 5.4e-14 51.6 0.6 1.9 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-AN1 PF01428.16 EDK40957.2 - 0.0038 17.4 9.7 0.0038 17.4 9.7 3.6 4 0 0 4 4 4 1 AN1-like Zinc finger zf-C2H2_12 PF18658.1 EDK40957.2 - 0.084 12.5 4.8 0.32 10.6 0.2 3.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 EDK40957.2 - 0.74 10.8 0.1 0.74 10.8 0.1 5.4 5 1 1 6 6 6 0 C2H2-type zinc finger Spore_III_AB PF09548.10 EDK40957.2 - 1.4 9.1 7.2 2.6 8.1 7.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF16 PF01519.16 EDK40957.2 - 5.3 7.6 12.3 37 4.9 9.6 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 Sugar_tr PF00083.24 EDK40958.2 - 2.3e-113 379.4 22.8 2.7e-113 379.2 22.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK40958.2 - 7.6e-20 71.1 25.0 7.6e-20 71.1 25.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily DAO PF01266.24 EDK40959.2 - 9.6e-18 64.9 0.0 1.1e-17 64.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase CDC45 PF02724.14 EDK40960.2 - 6.7e-197 655.7 5.1 2.5e-195 650.5 5.1 2.0 1 1 0 1 1 1 1 CDC45-like protein Astro_capsid_p PF12226.8 EDK40960.2 - 0.075 12.2 9.2 0.059 12.5 6.8 1.8 2 0 0 2 2 2 0 Turkey astrovirus capsid protein PI3K_1B_p101 PF10486.9 EDK40960.2 - 0.3 8.8 3.4 0.41 8.4 3.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nop14 PF04147.12 EDK40960.2 - 1.8 6.7 8.1 2.6 6.1 8.1 1.1 1 0 0 1 1 1 0 Nop14-like family MPM1 PF17234.2 EDK40960.2 - 5.7 7.2 7.4 10 6.3 7.4 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF2415 PF10313.9 EDK40961.2 - 1.1e-20 73.2 0.3 2.4e-20 72.2 0.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) DLH PF01738.18 EDK40963.2 - 5.5e-21 75.1 0.0 6.4e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family S19 PF06756.11 EDK40963.2 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Chorion protein S19 C-terminal DLH PF01738.18 EDK40964.1 - 7.8e-17 61.5 0.0 9e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Exo_endo_phos PF03372.23 EDK40965.2 - 7.6e-15 55.1 0.0 9.8e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4405 PF14358.6 EDK40965.2 - 0.21 12.1 7.4 0.23 12.0 3.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Spindle_Spc25 PF08234.12 EDK40966.2 - 9.6e-19 67.4 0.3 2.8e-18 65.9 0.3 1.9 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 JIP_LZII PF16471.5 EDK40966.2 - 0.006 16.7 3.8 0.006 16.7 3.8 4.1 4 1 0 4 4 4 1 JNK-interacting protein leucine zipper II AbfB PF05270.13 EDK40966.2 - 0.1 12.6 0.4 9.4 6.2 0.0 2.4 2 0 0 2 2 2 0 Alpha-L-arabinofuranosidase B (ABFB) domain ACP PF06857.11 EDK40966.2 - 0.12 12.7 1.2 0.41 10.9 0.9 2.0 1 1 0 1 1 1 0 Malonate decarboxylase delta subunit (MdcD) Fucose_iso_N2 PF07882.12 EDK40966.2 - 0.13 11.9 12.3 0.056 13.0 3.4 3.1 2 2 1 3 3 3 0 L-fucose isomerase, second N-terminal domain Spc7 PF08317.11 EDK40966.2 - 0.6 8.9 28.0 0.053 12.4 11.9 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Prominin PF05478.11 EDK40966.2 - 1.2 7.0 10.1 0.56 8.1 6.6 1.9 2 0 0 2 2 2 0 Prominin DUF3915 PF13054.6 EDK40966.2 - 6.9 6.7 12.8 0.43 10.6 6.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF2470 PF10615.9 EDK40967.1 - 1.1e-13 51.6 0.0 1.5e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF768 PF05589.11 EDK40967.1 - 0.22 11.6 0.4 0.57 10.2 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF768) adh_short PF00106.25 EDK40968.2 - 6.3e-08 32.3 0.0 4.6e-07 29.5 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK40968.2 - 0.093 12.3 0.0 2.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase SAE2 PF08573.10 EDK40970.2 - 0.031 15.4 3.6 0.14 13.2 0.8 2.6 3 0 0 3 3 3 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Filament_head PF04732.14 EDK40970.2 - 0.46 11.4 6.9 0.087 13.7 2.2 2.1 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region WD40 PF00400.32 EDK40972.2 - 0.00062 20.5 21.5 0.15 13.0 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat TFIID_30kDa PF03540.13 EDK40973.2 - 8.6e-26 89.7 0.0 1.4e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit MFS_1 PF07690.16 EDK40974.1 - 3.7e-35 121.5 19.7 3.7e-35 121.5 19.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily HECT PF00632.25 EDK40975.2 - 1.1e-82 277.9 0.0 2.8e-82 276.7 0.0 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HypF_C PF17788.1 EDK40975.2 - 0.048 14.4 0.0 0.17 12.6 0.0 2.0 1 0 0 1 1 1 0 HypF Kae1-like domain F-actin_cap_A PF01267.17 EDK40976.2 - 1.3e-66 224.8 4.5 1.4e-66 224.6 4.5 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Syntaxin_2 PF14523.6 EDK40977.2 - 0.0059 17.0 0.6 0.0065 16.8 0.6 1.1 1 0 0 1 1 1 1 Syntaxin-like protein Vma12 PF11712.8 EDK40977.2 - 0.073 13.1 0.3 0.085 12.9 0.3 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SRA1 PF07304.11 EDK40977.2 - 0.097 12.5 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) VHS PF00790.19 EDK40978.2 - 1.3e-32 112.5 1.0 2.9e-32 111.4 1.0 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EDK40978.2 - 1.5e-14 53.3 0.0 2.6e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK40978.2 - 9.3e-13 47.8 0.1 1.7e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK40978.2 - 1.8e-11 43.6 0.0 3.2e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EDK40978.2 - 6.7e-07 29.5 1.8 2.4e-06 27.7 1.8 2.0 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 EDK40978.2 - 7.4e-05 22.4 1.4 0.00026 20.7 1.4 2.0 1 0 0 1 1 1 1 Ubiquitin interaction motif TRAM_LAG1_CLN8 PF03798.16 EDK40979.1 - 2.6e-38 131.8 22.6 2.6e-38 131.8 22.6 2.2 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 EDK40979.1 - 1.6e-19 69.3 0.2 1.6e-19 69.3 0.2 2.7 3 0 0 3 3 3 1 TRAM1-like protein Ribosomal_S2 PF00318.20 EDK40981.2 - 8e-67 224.6 3.9 3e-66 222.8 0.1 2.6 2 1 0 2 2 2 1 Ribosomal protein S2 Methyltrn_RNA_4 PF09936.9 EDK40981.2 - 0.39 10.5 1.4 0.37 10.6 0.1 1.5 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase FliT PF05400.13 EDK40981.2 - 0.59 11.0 10.4 1.4 9.8 10.4 1.6 1 0 0 1 1 1 0 Flagellar protein FliT CS PF04969.16 EDK40982.2 - 0.0006 20.8 1.1 0.0012 19.8 1.1 1.5 1 0 0 1 1 1 1 CS domain Syja_N PF02383.18 EDK40984.2 - 4.5e-83 279.2 1.2 4.5e-83 279.2 1.2 3.2 3 1 1 4 4 4 1 SacI homology domain TMEM215 PF15746.5 EDK40984.2 - 0.33 10.4 4.9 4.2 6.8 0.1 2.5 2 0 0 2 2 2 0 TMEM215 family ATP-sulfurylase PF01747.17 EDK40985.2 - 3.8e-80 268.3 0.0 5.2e-80 267.9 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 EDK40985.2 - 1.2e-52 177.8 0.0 1.9e-52 177.1 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain CTP_transf_like PF01467.26 EDK40985.2 - 0.056 13.6 0.0 0.29 11.3 0.0 2.2 2 1 0 2 2 2 0 Cytidylyltransferase-like 6PGD PF00393.19 EDK40986.2 - 4.1e-129 430.1 0.0 4.9e-129 429.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EDK40986.2 - 4.4e-13 49.7 0.0 7.5e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EDK40986.2 - 0.044 14.0 0.0 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ANT PF03374.14 EDK40986.2 - 0.15 12.4 0.0 1.9 8.8 0.0 2.2 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain p450 PF00067.22 EDK40987.2 - 2.4e-49 168.3 0.0 3.1e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NOC3p PF07540.11 EDK40988.2 - 1.3e-26 92.8 0.3 4.9e-26 91.0 0.3 2.1 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 EDK40988.2 - 4.4e-22 78.9 0.0 1.4e-21 77.3 0.0 1.9 1 0 0 1 1 1 1 CBF/Mak21 family SPRY PF00622.28 EDK40989.2 - 5.1e-11 42.8 0.2 1.6e-10 41.1 0.0 1.9 2 0 0 2 2 2 1 SPRY domain DUF3097 PF11296.8 EDK40990.2 - 0.15 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) AT_hook PF02178.19 EDK40990.2 - 0.72 9.9 14.9 0.55 10.3 3.4 2.7 2 0 0 2 2 2 0 AT hook motif DUF2870 PF11069.8 EDK40990.2 - 0.75 10.2 7.5 1 9.8 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Biotin_lipoyl PF00364.22 EDK40991.2 - 2.5e-19 68.9 0.5 4.2e-19 68.1 0.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDK40991.2 - 6.7e-07 29.5 0.1 2.1e-06 28.0 0.0 2.0 2 0 0 2 2 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EDK40991.2 - 0.0012 18.6 0.0 0.03 14.2 0.0 2.9 3 0 0 3 3 3 1 Biotin-lipoyl like RNA_pol_Rpc4 PF05132.14 EDK40991.2 - 0.016 15.7 3.1 0.016 15.7 3.1 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Cyclin PF08613.11 EDK40991.2 - 0.069 13.5 0.2 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Cyclin Macoilin PF09726.9 EDK40991.2 - 0.16 10.5 6.5 0.2 10.2 6.5 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EDK40991.2 - 0.17 10.6 3.1 0.23 10.2 3.1 1.1 1 0 0 1 1 1 0 Presenilin SET PF00856.28 EDK40991.2 - 0.31 11.4 3.9 0.35 11.2 2.3 1.8 1 1 1 2 2 2 0 SET domain Hid1 PF12722.7 EDK40991.2 - 0.43 8.6 3.1 0.48 8.5 3.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rtf2 PF04641.12 EDK40991.2 - 1.5 8.1 10.5 2.4 7.4 10.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Tim54 PF11711.8 EDK40991.2 - 4.3 6.0 9.2 7.3 5.3 9.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ANAPC_CDC26 PF10471.9 EDK40991.2 - 5.4 7.9 10.9 14 6.6 10.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Nramp PF01566.18 EDK40992.2 - 1.1e-88 297.6 11.0 1.2e-49 169.2 7.0 2.1 1 1 1 2 2 2 2 Natural resistance-associated macrophage protein Hydrolase_4 PF12146.8 EDK40993.2 - 6.9e-12 45.1 0.0 6.7e-11 41.9 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK40993.2 - 6.4e-11 42.4 0.0 1.3e-08 34.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF1100 PF06500.11 EDK40993.2 - 4.5e-10 38.9 0.0 6.8e-09 35.0 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1100) AXE1 PF05448.12 EDK40993.2 - 3.8e-09 35.7 0.0 5.9e-06 25.2 0.0 2.9 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 EDK40993.2 - 1.4e-08 34.6 0.0 1.8e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EDK40993.2 - 1.8e-07 32.0 0.0 2.3e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EDK40993.2 - 3.6e-07 30.0 0.0 0.002 17.7 0.0 2.7 2 1 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EDK40993.2 - 2.2e-06 27.3 0.0 7.2e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EDK40993.2 - 7.3e-06 26.0 0.0 0.0054 16.7 0.0 2.1 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 EDK40993.2 - 0.059 13.2 0.0 13 5.6 0.0 2.7 3 0 0 3 3 3 0 Serine hydrolase PAF-AH_p_II PF03403.13 EDK40993.2 - 0.16 10.5 0.0 4.1 5.8 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II SRP9-21 PF05486.12 EDK40994.2 - 1.5e-24 86.2 0.6 1.5e-24 86.2 0.6 2.4 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Di19_C PF14571.6 EDK40994.2 - 9.2 6.9 10.8 1.8 9.1 4.4 2.4 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal AMPK1_CBM PF16561.5 EDK40995.2 - 1.7e-10 41.0 0.0 4.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM53 PF16760.5 EDK40995.2 - 0.0047 17.5 0.0 0.014 15.9 0.0 1.8 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) GREB1 PF15782.5 EDK40995.2 - 1.3 6.1 6.3 1.4 6.0 6.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PMT PF02366.18 EDK40998.2 - 6.1e-81 271.6 15.7 6.1e-81 271.6 15.7 2.4 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDK40998.2 - 1e-61 208.0 22.0 1e-61 208.0 22.0 1.7 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDK40998.2 - 8.7e-48 162.6 0.0 1.9e-47 161.5 0.0 1.5 1 0 0 1 1 1 1 MIR domain HAD_2 PF13419.6 EDK40999.1 - 4e-18 66.1 0.0 7.2e-18 65.3 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK40999.1 - 1.5e-09 38.5 0.0 4.4e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDK40999.1 - 0.0036 17.7 0.0 0.0079 16.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EDK40999.1 - 0.054 13.6 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Pex2_Pex12 PF04757.14 EDK41000.2 - 3.3e-38 131.5 10.6 4.8e-38 131.0 10.6 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_5 PF14634.6 EDK41000.2 - 0.00028 20.8 4.6 0.00064 19.6 4.6 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDK41000.2 - 0.00068 19.6 3.0 0.0016 18.4 3.0 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDK41000.2 - 0.0057 16.5 4.3 0.012 15.5 4.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK41000.2 - 0.0083 16.0 2.7 0.011 15.6 0.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK41000.2 - 0.02 15.1 1.8 0.02 15.1 1.8 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EDK41000.2 - 0.047 14.0 2.3 0.089 13.1 2.3 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDK41000.2 - 0.7 10.3 6.4 3.6 8.0 6.4 2.0 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 EDK41000.2 - 0.94 9.4 5.3 1.5 8.7 1.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EDK41000.2 - 1.7 8.9 4.6 5.4 7.2 4.6 1.8 1 1 0 1 1 1 0 FYVE zinc finger CPL PF08144.11 EDK41001.2 - 1.3e-46 158.5 6.6 1.2e-42 145.6 0.1 4.7 3 1 1 4 4 4 3 CPL (NUC119) domain PUF PF00806.19 EDK41001.2 - 0.00057 19.4 0.9 11 6.0 0.0 4.9 4 0 0 4 4 4 1 Pumilio-family RNA binding repeat DUF4253 PF14062.6 EDK41001.2 - 0.049 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) CDC45 PF02724.14 EDK41001.2 - 0.066 11.5 22.4 0.11 10.7 22.4 1.4 1 0 0 1 1 1 0 CDC45-like protein SAC3 PF12209.8 EDK41001.2 - 1 9.6 5.5 3.6 7.8 0.1 4.0 4 1 0 4 4 4 0 Leucine permease transcriptional regulator helical domain RRN3 PF05327.11 EDK41001.2 - 7.2 5.0 25.7 42 2.5 0.0 2.8 2 1 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Thioredoxin PF00085.20 EDK41002.1 - 1.5e-26 92.3 0.1 1.9e-26 92.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDK41002.1 - 1.7e-05 25.2 0.1 0.00065 20.1 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.16 EDK41002.1 - 1.8e-05 23.8 0.0 2.2e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 Phosducin Thioredoxin_9 PF14595.6 EDK41002.1 - 2.6e-05 24.0 0.0 3.4e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDK41002.1 - 0.0011 19.2 0.0 0.01 16.1 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EDK41002.1 - 0.0021 17.5 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HyaE PF07449.11 EDK41002.1 - 0.019 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 EDK41002.1 - 0.057 13.2 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein AAA PF00004.29 EDK41003.2 - 3.9e-40 137.3 0.0 6.7e-40 136.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK41003.2 - 1.5e-10 40.7 0.7 3e-10 39.7 0.7 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDK41003.2 - 1.1e-09 38.1 0.1 2e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EDK41003.2 - 6.4e-06 26.5 0.3 0.022 15.0 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 EDK41003.2 - 1e-05 25.8 0.0 2.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDK41003.2 - 2.9e-05 23.4 0.0 5.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EDK41003.2 - 0.00031 21.2 0.2 0.0091 16.4 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDK41003.2 - 0.00034 20.6 0.1 0.0014 18.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDK41003.2 - 0.00095 18.9 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDK41003.2 - 0.0034 17.6 0.0 0.0089 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDK41003.2 - 0.014 15.4 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDK41003.2 - 0.02 15.1 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDK41003.2 - 0.021 14.6 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 EDK41003.2 - 0.021 14.7 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDK41003.2 - 0.024 15.2 0.1 0.061 13.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 EDK41003.2 - 0.032 13.4 0.1 0.078 12.2 0.1 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 EDK41003.2 - 0.04 13.3 0.1 0.65 9.3 0.1 2.2 1 1 0 2 2 2 0 KaiC RNA_helicase PF00910.22 EDK41003.2 - 0.046 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EDK41003.2 - 0.067 12.6 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EDK41003.2 - 0.092 12.3 0.1 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDK41003.2 - 0.099 12.6 0.1 0.56 10.1 0.0 2.3 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 EDK41003.2 - 0.11 11.7 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EDK41003.2 - 0.13 12.0 0.2 0.4 10.4 0.2 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EDK41003.2 - 0.14 12.1 0.1 0.72 9.8 0.1 2.2 1 1 1 2 2 2 0 NACHT domain Bax1-I PF01027.20 EDK41004.1 - 9.2e-52 175.9 30.3 1.1e-51 175.7 30.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 EDK41004.1 - 2.1e-09 37.3 11.3 2.6e-09 37.0 11.3 1.1 1 0 0 1 1 1 1 Bax inhibitor 1 like zf-RING_UBOX PF13445.6 EDK41005.2 - 1.5e-10 40.9 5.4 2e-10 40.5 2.9 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDK41005.2 - 2.2e-10 40.2 6.2 3.2e-10 39.7 2.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDK41005.2 - 4.3e-10 39.7 5.7 6.7e-10 39.1 5.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDK41005.2 - 4.7e-10 39.2 5.3 7.8e-10 38.5 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDK41005.2 - 5.2e-09 35.8 6.3 1.6e-08 34.3 6.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK41005.2 - 1.4e-07 31.6 4.4 3.5e-07 30.3 4.4 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDK41005.2 - 3.3e-07 30.0 7.8 6e-06 26.0 8.3 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EDK41005.2 - 1.7e-06 27.9 6.9 3.4e-06 26.9 6.9 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EDK41005.2 - 0.0032 17.2 4.9 0.0084 15.8 4.9 1.8 1 0 0 1 1 1 1 RING-like zinc finger FANCL_C PF11793.8 EDK41005.2 - 0.004 17.3 4.3 0.018 15.2 4.3 1.9 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_4 PF14570.6 EDK41005.2 - 0.009 15.8 3.8 0.052 13.4 3.9 2.2 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 EDK41005.2 - 0.018 14.4 1.2 0.023 14.0 1.2 1.3 1 1 0 1 1 1 0 Rtf2 RING-finger TerY_C PF15616.6 EDK41005.2 - 0.022 14.9 5.4 0.43 10.7 5.3 2.1 1 1 0 1 1 1 0 TerY-C metal binding domain zf-RING_14 PF17978.1 EDK41005.2 - 0.027 14.9 1.9 0.037 14.4 1.9 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EDK41005.2 - 0.079 13.0 2.8 0.29 11.2 2.8 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4451 PF14616.6 EDK41005.2 - 0.1 12.8 3.0 1.1 9.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) FYVE PF01363.21 EDK41005.2 - 0.11 12.7 5.1 0.26 11.4 5.1 1.7 1 1 0 1 1 1 0 FYVE zinc finger zf-rbx1 PF12678.7 EDK41005.2 - 0.12 12.7 8.7 0.81 10.0 8.6 2.1 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-MIZ PF02891.20 EDK41005.2 - 0.17 11.6 6.2 0.45 10.3 6.2 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-piccolo PF05715.13 EDK41005.2 - 0.29 11.3 6.0 6.6 7.0 2.5 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger CcmH PF03918.14 EDK41005.2 - 1.6 8.0 3.8 4.5 6.5 0.2 2.2 1 1 1 2 2 2 0 Cytochrome C biogenesis protein PH PF00169.29 EDK41006.2 - 1.8e-10 41.2 0.5 3.6e-10 40.3 0.5 1.5 1 0 0 1 1 1 1 PH domain CHDCT2 PF08074.11 EDK41006.2 - 0.15 12.2 2.7 2.7 8.1 0.0 2.9 2 1 1 3 3 3 0 CHDCT2 (NUC038) domain Ribosomal_L14 PF00238.19 EDK41007.1 - 3.6e-33 114.2 0.0 4.1e-33 114.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e WSC PF01822.19 EDK41008.2 - 1e-10 41.6 16.3 1e-10 41.6 16.3 2.8 3 1 0 3 3 3 1 WSC domain Podoplanin PF05808.11 EDK41008.2 - 6.1e-05 23.2 13.8 6.1e-05 23.2 13.8 2.2 1 1 1 2 2 2 1 Podoplanin Utp14 PF04615.13 EDK41008.2 - 0.0021 16.7 4.5 0.0026 16.4 4.5 1.1 1 0 0 1 1 1 1 Utp14 protein SKG6 PF08693.10 EDK41008.2 - 0.068 12.6 0.0 0.32 10.4 0.0 2.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PPP4R2 PF09184.11 EDK41008.2 - 3.1 7.3 14.1 6.3 6.3 14.1 1.5 1 1 0 1 1 1 0 PPP4R2 GREB1 PF15782.5 EDK41008.2 - 5.2 4.1 18.0 6.5 3.7 18.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hamartin PF04388.12 EDK41008.2 - 9.9 4.7 27.0 13 4.3 27.0 1.1 1 0 0 1 1 1 0 Hamartin protein Epimerase PF01370.21 EDK41009.2 - 1.3e-16 60.8 0.0 2.1e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41009.2 - 2e-11 43.4 0.0 2.6e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK41009.2 - 6e-10 38.7 0.0 2.7e-07 30.0 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDK41009.2 - 1.3e-08 34.9 0.0 2.4e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EDK41009.2 - 0.0001 21.8 0.1 0.00028 20.4 0.1 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EDK41009.2 - 0.0018 17.9 0.0 0.028 14.0 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDK41009.2 - 0.0032 17.0 0.1 0.0059 16.1 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.20 EDK41009.2 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Use1 PF09753.9 EDK41010.2 - 1.4e-15 57.8 0.1 1.7e-15 57.5 0.1 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF1690 PF07956.11 EDK41010.2 - 0.71 10.3 3.6 2.2 8.7 0.4 2.5 1 1 2 3 3 3 0 Protein of Unknown function (DUF1690) RRM_1 PF00076.22 EDK41011.2 - 1e-26 92.5 0.6 4.7e-08 32.7 0.3 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDK41011.2 - 5.8e-09 35.7 0.0 0.64 9.9 0.0 4.4 4 0 0 4 4 4 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDK41011.2 - 0.015 15.2 0.1 1.4 9.0 0.1 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 EDK41011.2 - 0.049 13.4 0.0 0.83 9.4 0.0 2.8 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain COX4 PF02936.14 EDK41013.1 - 2.4e-34 118.3 0.1 3e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV UvrA_DNA-bind PF17755.1 EDK41013.1 - 0.0079 16.5 0.8 1 9.7 0.0 2.5 2 1 1 3 3 3 2 UvrA DNA-binding domain Pkinase PF00069.25 EDK41014.2 - 5.2e-45 153.9 0.0 2.9e-44 151.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41014.2 - 3.2e-24 85.6 0.0 6.6e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase GATA PF00320.27 EDK41015.2 - 1.6e-31 107.6 17.0 1.7e-16 59.5 5.5 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDK41015.2 - 1.6e-06 27.5 5.7 0.0041 16.6 0.4 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EDK41015.2 - 4.1e-05 23.6 0.5 0.2 11.8 0.0 2.6 2 0 0 2 2 2 2 Zinc ribbon domain ArfGap PF01412.18 EDK41015.2 - 6.4e-05 23.0 1.9 0.033 14.3 0.2 2.3 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf TDP43_N PF18694.1 EDK41015.2 - 0.00011 22.0 0.1 0.68 9.8 0.0 2.4 2 0 0 2 2 2 2 Transactive response DNA-binding protein N-terminal domain zf-RRN7 PF11781.8 EDK41015.2 - 0.00032 20.3 4.0 0.24 11.1 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Auto_anti-p27 PF06677.12 EDK41015.2 - 0.00049 20.2 4.5 0.15 12.2 0.4 2.5 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.11 EDK41015.2 - 0.02 14.8 0.3 0.02 14.8 0.3 2.8 3 0 0 3 3 2 0 Putative transposase DNA-binding domain zf-RRPl_C4 PF17026.5 EDK41015.2 - 0.036 14.2 3.4 1.4 9.1 0.1 2.4 2 1 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type eIF-5_eIF-2B PF01873.17 EDK41015.2 - 0.055 13.4 4.2 4.3 7.2 0.5 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zinc_ribbon_9 PF14369.6 EDK41015.2 - 0.1 12.9 0.3 0.1 12.9 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon DZR PF12773.7 EDK41015.2 - 0.16 12.0 11.1 0.42 10.7 0.2 3.0 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EDK41015.2 - 0.26 10.8 12.2 5.5 6.6 0.1 4.3 4 0 0 4 4 4 0 zinc-ribbon domain zf-B_box PF00643.24 EDK41015.2 - 0.61 10.3 2.9 27 5.0 0.1 3.2 3 1 0 3 3 3 0 B-box zinc finger Nudix_N_2 PF14803.6 EDK41015.2 - 1.5 8.8 6.9 21 5.1 1.4 3.3 2 2 0 2 2 2 0 Nudix N-terminal Mito_carr PF00153.27 EDK41016.1 - 1.1e-53 179.2 2.3 5.9e-18 64.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fer4 PF00037.27 EDK41017.2 - 9e-14 50.6 17.0 3.8e-08 32.8 4.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EDK41017.2 - 5.8e-13 49.2 10.3 1.3e-12 48.1 10.3 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDK41017.2 - 2.6e-10 40.2 21.0 4.2e-07 30.0 12.0 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EDK41017.2 - 6.3e-10 39.8 11.8 3.3e-05 24.7 1.8 2.4 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 EDK41017.2 - 2.5e-09 37.1 21.9 1.3e-07 31.7 11.0 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EDK41017.2 - 4.8e-09 36.2 31.6 8.9e-06 25.7 12.4 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDK41017.2 - 2.5e-08 34.3 18.9 5.8e-05 23.5 10.5 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EDK41017.2 - 1.6e-06 27.9 17.5 0.00041 20.3 5.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EDK41017.2 - 2.1e-06 27.5 11.3 0.0059 16.6 1.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EDK41017.2 - 1.6e-05 25.1 11.2 0.00031 21.0 1.8 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EDK41017.2 - 0.00015 22.2 12.6 0.024 15.2 2.4 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EDK41017.2 - 0.024 14.9 6.3 0.75 10.1 0.4 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 EDK41017.2 - 0.038 14.5 15.0 0.76 10.4 4.3 2.8 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EDK41017.2 - 0.053 13.7 8.9 1.1 9.4 1.4 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EDK41017.2 - 0.058 14.4 15.7 0.12 13.3 3.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 EDK41017.2 - 0.064 13.4 5.3 0.2 11.8 0.3 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 EDK41017.2 - 0.26 12.2 11.3 0.81 10.6 1.2 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain DSPc PF00782.20 EDK41019.2 - 5e-26 91.1 0.0 1.4e-24 86.4 0.0 2.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDK41019.2 - 0.00017 21.2 0.0 0.00027 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EDK41019.2 - 0.0026 18.0 0.0 0.0096 16.2 0.0 1.9 1 0 0 1 1 1 1 Rit1 DUSP-like domain Ank_2 PF12796.7 EDK41020.2 - 7.6e-25 87.3 1.2 6e-15 55.6 0.2 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK41020.2 - 1.7e-21 76.3 0.9 8.4e-08 32.6 0.0 5.5 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDK41020.2 - 2.2e-21 75.6 3.0 6.3e-07 29.6 0.1 4.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EDK41020.2 - 2.2e-19 68.9 1.7 1.2e-05 25.5 0.2 6.9 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 EDK41020.2 - 4.5e-18 63.5 1.2 2.2e-05 24.4 0.1 6.1 6 0 0 6 6 6 4 Ankyrin repeat DUF2011 PF09428.10 EDK41021.1 - 5e-19 68.3 0.3 1.1e-18 67.3 0.3 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) COG5 PF10392.9 EDK41022.2 - 4.2e-37 127.3 0.1 9.5e-37 126.1 0.1 1.6 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Sec23_trunk PF04811.15 EDK41023.2 - 1.1e-65 221.6 0.0 1.6e-65 221.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDK41023.2 - 5.2e-23 80.8 0.0 1.3e-22 79.6 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDK41023.2 - 2.3e-17 63.5 0.0 7e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDK41023.2 - 1.4e-14 53.8 7.1 2.5e-14 53.0 7.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDK41023.2 - 0.0011 18.8 0.0 0.0037 17.1 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDK41023.2 - 0.12 11.7 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF4336 PF14234.6 EDK41024.2 - 0.0082 15.4 0.4 0.95 8.6 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) Epimerase PF01370.21 EDK41025.2 - 7.7e-25 87.8 0.2 1.2e-24 87.1 0.2 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41025.2 - 6e-22 78.0 0.1 7.8e-22 77.6 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK41025.2 - 2e-17 63.2 0.2 5.5e-17 61.8 0.2 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDK41025.2 - 2.9e-14 53.4 0.1 3.8e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EDK41025.2 - 7e-14 52.0 0.0 9.5e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EDK41025.2 - 2.9e-09 36.8 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EDK41025.2 - 0.00019 21.4 0.1 0.00044 20.2 0.1 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDK41025.2 - 0.00087 18.5 0.1 0.0017 17.6 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDK41025.2 - 0.016 14.7 0.0 0.039 13.4 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase DUF2639 PF11121.8 EDK41025.2 - 0.077 13.0 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) Abhydrolase_1 PF00561.20 EDK41026.2 - 6.1e-27 94.9 0.1 1.8e-26 93.4 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK41026.2 - 8.6e-26 90.7 0.2 2.5e-25 89.1 0.2 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDK41026.2 - 4.2e-18 66.8 0.0 5.2e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EDK41026.2 - 1.5e-07 31.1 0.2 0.011 15.2 0.2 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EDK41026.2 - 0.00033 20.5 0.1 0.1 12.3 0.1 2.5 2 1 0 2 2 2 2 Alpha/beta hydrolase family DUF915 PF06028.11 EDK41026.2 - 0.0021 17.4 0.2 0.009 15.4 0.1 2.0 3 1 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.18 EDK41026.2 - 0.0034 17.0 0.0 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 EDK41026.2 - 0.0098 14.8 0.1 0.02 13.8 0.1 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 EDK41026.2 - 0.023 14.5 0.0 0.088 12.6 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF1749 PF08538.10 EDK41026.2 - 0.061 12.4 0.0 0.19 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) PAF-AH_p_II PF03403.13 EDK41026.2 - 0.11 11.0 0.1 3.2 6.2 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.11 EDK41026.2 - 0.11 11.5 0.0 0.23 10.4 0.0 1.5 1 1 0 1 1 1 0 Chlorophyllase Ndr PF03096.14 EDK41026.2 - 0.13 10.9 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family Ser_hydrolase PF06821.13 EDK41026.2 - 0.14 12.0 0.0 1.3 8.9 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase ADH_zinc_N PF00107.26 EDK41027.2 - 8.3e-14 51.7 0.3 1.4e-13 50.9 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK41027.2 - 5.5e-06 26.2 1.0 4.7e-05 23.2 0.4 2.5 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDK41027.2 - 0.0068 17.5 0.1 0.019 16.0 0.1 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase 4HBT PF03061.22 EDK41028.1 - 3.5e-08 33.7 0.0 6.3e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Glyco_hydro38C2 PF17677.1 EDK41028.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Asn_synthase PF00733.21 EDK41029.2 - 3.6e-18 66.4 0.4 2.3e-13 50.5 0.3 3.2 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDK41029.2 - 1.2e-09 38.1 0.4 2.6e-08 33.8 0.0 3.0 3 1 0 3 3 3 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDK41029.2 - 0.00013 22.2 0.0 0.00051 20.3 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase domain CReP_N PF10472.9 EDK41029.2 - 0.063 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor Glutaredoxin PF00462.24 EDK41030.2 - 0.088 13.0 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Glutaredoxin TFIIE-A_C PF11521.8 EDK41030.2 - 1.3 9.3 5.7 0.98 9.8 2.6 2.4 2 1 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Pkinase PF00069.25 EDK41031.2 - 4.1e-27 95.2 0.5 8.3e-27 94.2 0.2 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41031.2 - 3e-13 49.7 0.0 7.8e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase ParcG PF10274.9 EDK41031.2 - 0.0028 17.8 0.5 0.0061 16.7 0.1 1.7 2 0 0 2 2 2 1 Parkin co-regulated protein Csc2 PF18320.1 EDK41031.2 - 0.043 12.8 0.3 0.09 11.7 0.3 1.5 1 0 0 1 1 1 0 Csc2 Crispr RRM_1 PF00076.22 EDK41032.2 - 1.6e-12 47.0 0.0 2.4e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gtr1_RagA PF04670.12 EDK41033.2 - 5.1e-96 320.5 4.9 6.6e-96 320.1 4.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EDK41033.2 - 2.4e-08 34.2 1.6 3.1e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK41033.2 - 3.8e-08 33.1 0.1 7.7e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EDK41033.2 - 3.9e-08 32.9 0.6 6.5e-08 32.2 0.1 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDK41033.2 - 2.2e-07 30.9 0.2 7.1e-07 29.3 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EDK41033.2 - 0.013 16.0 0.7 0.032 14.7 0.1 2.1 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EDK41033.2 - 0.017 14.3 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SUIM_assoc PF16619.5 EDK41033.2 - 0.024 14.7 1.0 0.027 14.5 0.1 1.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_29 PF13555.6 EDK41033.2 - 0.041 13.6 0.4 0.11 12.3 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CR6_interact PF10147.9 EDK41033.2 - 0.07 12.8 0.7 0.55 9.9 0.1 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 RsgA_GTPase PF03193.16 EDK41033.2 - 0.12 12.2 6.4 1.4 8.8 0.1 3.2 3 0 0 3 3 3 0 RsgA GTPase SQS_PSY PF00494.19 EDK41034.2 - 1.1e-44 152.9 0.0 1.4e-44 152.6 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase MINDY_DUB PF04424.13 EDK41035.2 - 4.3e-13 49.3 0.0 8.7e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 MINDY deubiquitinase DUF4205 PF13898.6 EDK41035.2 - 0.01 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) MecA PF05389.12 EDK41035.2 - 8.5 5.9 8.9 4.1 7.0 0.0 2.3 1 1 0 2 2 2 0 Negative regulator of genetic competence (MecA) Paf1 PF03985.13 EDK41036.2 - 6.4e-84 282.4 14.7 7.3e-84 282.2 14.7 1.0 1 0 0 1 1 1 1 Paf1 Chlor_dismutase PF06778.12 EDK41036.2 - 0.091 12.3 0.2 7.9 6.0 0.0 2.4 2 0 0 2 2 2 0 Chlorite dismutase Cupin_8 PF13621.6 EDK41036.2 - 0.15 11.7 3.6 0.66 9.6 0.3 2.3 2 0 0 2 2 2 0 Cupin-like domain FMN_red PF03358.15 EDK41037.2 - 1.7e-12 47.4 0.0 2.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EDK41037.2 - 4.8e-05 23.2 0.0 6.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EDK41037.2 - 0.0031 17.8 0.0 0.0041 17.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_1 PF00258.25 EDK41037.2 - 0.06 13.6 0.2 2.4 8.4 0.2 2.3 1 1 0 1 1 1 0 Flavodoxin Aldo_ket_red PF00248.21 EDK41038.2 - 1.1e-26 93.7 0.0 1e-24 87.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Ras PF00071.22 EDK41039.2 - 1.4e-51 174.4 0.4 1.7e-51 174.1 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK41039.2 - 2.5e-35 121.3 0.2 4e-35 120.6 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK41039.2 - 9.1e-16 57.8 0.1 1.1e-15 57.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDK41039.2 - 6.1e-08 32.3 0.2 7.5e-08 32.0 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDK41039.2 - 2.7e-07 30.6 0.0 4.5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK41039.2 - 7.8e-07 28.8 0.1 2.6e-05 23.9 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EDK41039.2 - 5.3e-05 22.7 0.2 7.7e-05 22.2 0.2 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EDK41039.2 - 6.1e-05 23.0 0.5 0.028 14.3 0.2 2.6 1 1 2 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 EDK41039.2 - 0.00011 22.1 0.3 0.008 16.0 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EDK41039.2 - 0.00047 19.9 0.6 0.0073 16.1 0.1 2.3 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EDK41039.2 - 0.00085 19.6 0.0 0.0074 16.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK41039.2 - 0.0021 18.4 0.0 0.0033 17.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EDK41039.2 - 0.0042 17.0 0.2 0.0057 16.6 0.1 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EDK41039.2 - 0.0044 16.8 0.1 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EDK41039.2 - 0.005 16.8 0.4 0.094 12.7 0.4 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDK41039.2 - 0.0055 16.6 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Septin PF00735.18 EDK41039.2 - 0.0096 15.2 0.2 0.022 14.0 0.2 1.6 1 0 0 1 1 1 1 Septin AAA_7 PF12775.7 EDK41039.2 - 0.014 15.0 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 EDK41039.2 - 0.017 14.3 0.1 0.027 13.7 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain G-alpha PF00503.20 EDK41039.2 - 0.027 13.6 3.2 0.091 11.9 3.1 2.0 1 1 0 1 1 1 0 G-protein alpha subunit TniB PF05621.11 EDK41039.2 - 0.03 13.7 0.1 0.048 13.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MCM PF00493.23 EDK41039.2 - 0.048 12.8 0.1 0.083 12.0 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain cobW PF02492.19 EDK41039.2 - 0.049 13.2 0.5 0.14 11.7 0.1 1.9 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 EDK41039.2 - 0.055 13.5 0.5 0.14 12.1 0.1 1.9 2 1 1 3 3 2 0 AAA domain NTPase_1 PF03266.15 EDK41039.2 - 0.061 13.2 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 NTPase RNA_helicase PF00910.22 EDK41039.2 - 0.081 13.3 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase PRK PF00485.18 EDK41039.2 - 0.11 12.3 0.5 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 EDK41039.2 - 0.13 12.7 0.0 0.37 11.2 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EDK41039.2 - 0.16 12.5 1.6 0.29 11.7 1.6 1.8 1 1 0 1 1 1 0 ABC transporter DUF1771 PF08590.10 EDK41040.2 - 1.1e-20 73.8 13.2 1.1e-20 73.8 13.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 EDK41040.2 - 5.3e-11 42.7 0.6 9.8e-11 41.9 0.1 1.8 2 0 0 2 2 2 1 Smr domain Seryl_tRNA_N PF02403.22 EDK41040.2 - 0.00034 20.8 1.8 0.00074 19.7 1.8 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 EDK41040.2 - 0.14 11.5 4.1 0.2 10.9 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF883 PF05957.13 EDK41040.2 - 5.9 7.6 6.7 4.8 7.9 4.8 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Sugar_tr PF00083.24 EDK41041.2 - 2.9e-86 290.1 24.1 3.6e-86 289.8 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41041.2 - 3.4e-22 78.9 64.8 5.3e-20 71.6 38.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Zip PF02535.22 EDK41041.2 - 0.15 11.2 3.6 0.38 9.9 3.6 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter DHDPS PF00701.22 EDK41042.2 - 5.9e-36 123.7 0.0 7.1e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans PF04082.18 EDK41043.2 - 1.7e-16 60.1 1.7 2.9e-16 59.3 1.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK41043.2 - 3.8e-06 26.9 9.6 9.6e-06 25.6 9.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 EDK41043.2 - 0.0015 18.1 2.4 0.0029 17.2 2.4 1.4 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain GRDP-like PF07173.12 EDK41044.2 - 1.8e-20 74.0 2.7 2.8e-18 66.9 0.1 3.0 3 0 0 3 3 3 2 Glycine-rich domain-containing protein-like GRDP-like PF07173.12 EDK41045.2 - 1.9e-22 80.4 1.1 9.3e-20 71.7 0.0 3.1 3 0 0 3 3 3 2 Glycine-rich domain-containing protein-like MetOD1 PF18546.1 EDK41045.2 - 0.083 12.8 0.2 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Metanogen output domain 1 GTP_EFTU_D3 PF03143.17 EDK41046.1 - 7.2e-43 145.4 0.0 1.5e-42 144.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 EDK41046.1 - 3.8e-17 62.5 0.0 7.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDK41046.1 - 1.6e-13 50.8 2.7 1.6e-13 50.8 2.7 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EDK41046.1 - 2.9 7.9 5.9 0.88 9.5 1.5 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 BRCT PF00533.26 EDK41047.2 - 8e-36 122.3 7.2 2.1e-13 50.4 0.1 5.3 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDK41047.2 - 1e-22 79.8 8.4 1.2e-07 31.6 0.2 5.4 5 0 0 5 5 5 5 twin BRCT domain BRCT_2 PF16589.5 EDK41047.2 - 9.9e-16 57.9 2.6 0.00012 22.4 0.1 4.4 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EDK41047.2 - 0.00045 20.2 7.8 0.8 9.8 0.0 3.9 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EDK41047.2 - 0.16 11.9 0.2 26 4.8 0.0 3.9 5 0 0 5 5 5 0 Regulator of Ty1 transposition protein 107 BRCT domain KfrA_N PF11740.8 EDK41047.2 - 0.16 12.7 0.1 27 5.5 0.1 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term LIG3_BRCT PF16759.5 EDK41047.2 - 2.8 8.3 9.0 2 8.8 0.0 3.8 4 0 0 4 4 4 0 DNA ligase 3 BRCT domain Flocculin_t3 PF13928.6 EDK41048.1 - 0.011 16.2 8.0 0.011 16.2 8.0 3.4 1 1 2 3 3 3 0 Flocculin type 3 repeat Arrestin_C PF02752.22 EDK41048.1 - 0.055 13.9 1.3 0.066 13.7 1.3 1.2 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain Ribophorin_I PF04597.14 EDK41048.1 - 0.089 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Ribophorin I PLU-1 PF08429.11 EDK41049.2 - 1.1e-47 162.8 7.8 5.5e-47 160.6 0.9 2.8 3 0 0 3 3 3 2 PLU-1-like protein ARID PF01388.21 EDK41049.2 - 5.2e-16 59.1 0.0 2.6e-15 56.8 0.0 2.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjC PF02373.22 EDK41049.2 - 2.3e-14 53.8 0.2 7.1e-07 29.7 0.0 3.1 2 0 0 2 2 2 2 JmjC domain, hydroxylase PHD PF00628.29 EDK41049.2 - 2.2e-09 37.0 9.0 5.8e-09 35.7 9.0 1.7 1 0 0 1 1 1 1 PHD-finger DUF3829 PF12889.7 EDK41049.2 - 0.005 16.4 0.4 0.005 16.4 0.4 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3829) JmjN PF02375.17 EDK41049.2 - 0.025 14.5 0.0 0.12 12.4 0.0 2.3 1 0 0 1 1 1 0 jmjN domain Zf_RING PF16744.5 EDK41049.2 - 0.27 11.4 2.6 0.77 9.9 2.6 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 EDK41049.2 - 1.7 9.0 6.3 0.17 12.1 1.0 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain PHD_4 PF16866.5 EDK41049.2 - 8.9 6.5 9.4 6.9 6.8 6.4 2.4 2 0 0 2 2 2 0 PHD-finger TMF_TATA_bd PF12325.8 EDK41050.2 - 0.093 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding AA_permease_2 PF13520.6 EDK41051.2 - 4.9e-66 223.3 47.5 6e-66 223.0 47.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK41051.2 - 2.4e-15 56.1 37.7 3.4e-15 55.6 37.7 1.1 1 0 0 1 1 1 1 Amino acid permease US2 PF02476.15 EDK41051.2 - 0.089 13.5 0.1 0.16 12.6 0.1 1.4 1 0 0 1 1 1 0 US2 family DoxX_3 PF13781.6 EDK41051.2 - 0.24 12.1 8.0 7.2 7.3 0.4 3.2 3 0 0 3 3 3 0 DoxX-like family Phage_holin_2_4 PF16082.5 EDK41051.2 - 3.7 7.4 4.9 3.4 7.5 1.2 2.7 2 1 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Peptidase_S10 PF00450.22 EDK41052.2 - 3.7e-125 418.6 0.0 3.7e-125 418.6 0.0 1.4 2 0 0 2 2 2 1 Serine carboxypeptidase Rtf2 PF04641.12 EDK41054.2 - 1.2e-38 133.0 6.7 4.1e-38 131.2 6.7 1.7 1 1 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 EDK41054.2 - 7.6e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Mss51 PF13824.6 EDK41054.2 - 0.015 15.4 0.2 0.043 13.9 0.2 1.9 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 ADK_lid PF05191.14 EDK41054.2 - 0.029 14.4 0.1 0.079 13.0 0.1 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid zf-Nse PF11789.8 EDK41054.2 - 0.063 13.1 0.0 0.38 10.6 0.0 2.2 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C2HC_2 PF13913.6 EDK41054.2 - 0.083 12.8 1.4 0.083 12.8 1.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type CpXC PF14353.6 EDK41054.2 - 0.096 12.7 1.1 0.3 11.2 0.1 2.2 1 1 2 3 3 3 0 CpXC protein HNH PF01844.23 EDK41054.2 - 0.15 12.2 2.0 7.9 6.7 0.1 2.5 2 0 0 2 2 2 0 HNH endonuclease TetR_C_23 PF17931.1 EDK41054.2 - 0.35 11.0 2.5 1.5 9.0 0.6 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Rad50_zn_hook PF04423.14 EDK41054.2 - 0.42 10.5 0.1 0.42 10.5 0.1 2.8 3 0 0 3 3 3 0 Rad50 zinc hook motif Use1 PF09753.9 EDK41054.2 - 1.8 8.2 7.5 0.53 10.0 4.3 1.6 2 0 0 2 2 2 0 Membrane fusion protein Use1 Prefoldin PF02996.17 EDK41055.2 - 6.2e-25 87.4 0.9 7.7e-25 87.1 0.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit Matrilin_ccoil PF10393.9 EDK41055.2 - 0.0024 17.7 3.2 0.027 14.3 1.1 2.4 2 0 0 2 2 2 1 Trimeric coiled-coil oligomerisation domain of matrilin MCPVI PF02993.14 EDK41055.2 - 0.053 13.4 0.2 0.094 12.5 0.1 1.3 1 1 0 1 1 1 0 Minor capsid protein VI DUF3932 PF13068.6 EDK41055.2 - 0.054 13.8 0.1 0.093 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3932) DivIC PF04977.15 EDK41055.2 - 0.14 12.0 1.4 1.7 8.5 0.4 2.2 2 0 0 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 EDK41055.2 - 0.19 11.9 4.3 1.2 9.3 0.5 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 EDK41055.2 - 0.35 10.8 5.4 0.2 11.5 2.1 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HAUS2 PF15003.6 EDK41055.2 - 0.51 10.1 5.9 5.4 6.7 0.5 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 YlbE PF14003.6 EDK41055.2 - 2 8.9 5.8 0.77 10.2 0.4 2.4 2 1 1 3 3 3 0 YlbE-like protein Rad10 PF03834.14 EDK41056.2 - 8.9e-43 144.9 0.3 1.5e-42 144.2 0.3 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) CDC45 PF02724.14 EDK41056.2 - 0.0018 16.7 5.2 0.0024 16.2 5.2 1.2 1 0 0 1 1 1 1 CDC45-like protein Tim54 PF11711.8 EDK41056.2 - 0.013 14.3 5.9 0.021 13.6 5.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HHH_5 PF14520.6 EDK41056.2 - 0.016 15.8 0.0 0.031 14.9 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain Zip PF02535.22 EDK41056.2 - 0.09 12.0 5.4 0.11 11.8 5.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 EDK41056.2 - 0.16 11.7 3.8 0.23 11.2 3.8 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 EDK41056.2 - 0.21 10.3 12.9 0.3 9.8 12.9 1.2 1 0 0 1 1 1 0 Presenilin FAM76 PF16046.5 EDK41056.2 - 0.3 10.4 10.1 0.43 9.9 10.1 1.2 1 0 0 1 1 1 0 FAM76 protein Membralin PF09746.9 EDK41056.2 - 0.34 9.9 4.3 0.49 9.4 4.3 1.3 1 0 0 1 1 1 0 Tumour-associated protein Pex14_N PF04695.13 EDK41056.2 - 0.41 11.3 13.1 0.2 12.3 11.0 1.5 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sec62 PF03839.16 EDK41056.2 - 0.46 10.0 4.2 0.7 9.4 4.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 ZYG-11_interact PF05884.12 EDK41056.2 - 0.97 8.8 3.7 1.3 8.3 2.5 1.7 2 0 0 2 2 2 0 Interactor of ZYG-11 Spt20 PF12090.8 EDK41056.2 - 1.7 8.2 24.9 2.6 7.6 24.9 1.3 1 0 0 1 1 1 0 Spt20 family Band_3_cyto PF07565.13 EDK41056.2 - 1.9 8.2 8.2 3.2 7.5 8.2 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Roughex PF06020.11 EDK41056.2 - 2.2 7.3 10.2 3.2 6.8 10.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein ALMT PF11744.8 EDK41056.2 - 2.3 7.0 10.1 3.9 6.2 10.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CPSF100_C PF13299.6 EDK41056.2 - 2.4 8.3 9.9 4.5 7.4 9.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal STAC2_u1 PF16664.5 EDK41056.2 - 2.5 8.6 9.6 5.7 7.4 9.6 1.6 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Gti1_Pac2 PF09729.9 EDK41056.2 - 3 7.9 13.6 2.1 8.4 12.0 1.5 2 0 0 2 2 1 0 Gti1/Pac2 family Lin-8 PF03353.15 EDK41056.2 - 3.4 7.2 17.4 5 6.6 17.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RR_TM4-6 PF06459.12 EDK41056.2 - 4.1 7.2 11.8 6.8 6.4 11.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NST1 PF13945.6 EDK41056.2 - 5.6 7.0 23.0 11 6.0 23.0 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Fungal_trans PF04082.18 EDK41057.2 - 1.4e-14 53.7 5.5 2.1e-14 53.2 5.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK41057.2 - 1.5e-09 37.8 7.9 3e-09 36.8 7.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CemA PF03040.14 EDK41057.2 - 0.0023 17.9 0.2 0.0044 17.0 0.2 1.4 1 0 0 1 1 1 1 CemA family MFS_1 PF07690.16 EDK41058.2 - 4.5e-12 45.6 52.4 1.9e-06 27.1 25.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nairovirus_M PF07948.11 EDK41058.2 - 0.22 9.7 1.4 0.32 9.2 1.4 1.2 1 0 0 1 1 1 0 Nairovirus M polyprotein-like DUF2108 PF09881.9 EDK41058.2 - 0.44 10.5 5.3 3.2 7.8 0.2 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2108) Mito_morph_reg PF14972.6 EDK41058.2 - 2.2 7.9 5.1 3.7 7.1 0.1 2.6 2 0 0 2 2 2 0 Mitochondrial morphogenesis regulator Metallophos PF00149.28 EDK41059.2 - 2e-11 44.8 9.0 5.7e-11 43.3 3.0 3.1 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase MFS_1 PF07690.16 EDK41060.2 - 3.2e-35 121.7 48.0 3.2e-35 121.7 48.0 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK41060.2 - 0.0016 17.4 14.7 0.0016 17.4 14.7 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter Epimerase PF01370.21 EDK41061.1 - 1.3e-18 67.3 0.0 1.9e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41061.1 - 8.2e-14 51.3 0.0 1.1e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK41061.1 - 7.2e-11 42.3 0.0 1.2e-10 41.6 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK41061.1 - 1.3e-09 37.7 0.1 4.1e-07 29.4 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EDK41061.1 - 5.4e-05 22.9 0.6 0.00049 19.7 0.2 2.1 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EDK41061.1 - 0.00011 21.7 0.4 0.00023 20.7 0.4 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDK41061.1 - 0.0054 15.9 0.1 0.012 14.8 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDK41061.1 - 0.009 15.5 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase MucBP_2 PF17965.1 EDK41061.1 - 0.026 15.1 0.2 1.2 9.8 0.2 2.8 1 1 0 1 1 1 0 Mucin binding domain Shikimate_DH PF01488.20 EDK41061.1 - 0.033 14.2 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SLAIN PF15301.6 EDK41061.1 - 0.057 12.7 0.0 0.077 12.2 0.0 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family RmlD_sub_bind PF04321.17 EDK41061.1 - 0.09 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain KR PF08659.10 EDK41061.1 - 0.15 12.0 0.0 0.73 9.7 0.0 2.0 1 1 0 1 1 1 0 KR domain Thioredoxin PF00085.20 EDK41062.2 - 1.5e-27 95.6 0.0 1.6e-27 95.5 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EDK41062.2 - 3e-06 27.2 0.0 3.8e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EDK41062.2 - 3.3e-06 27.5 0.3 0.00015 22.2 0.3 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDK41062.2 - 4.5e-06 26.9 0.1 2.1e-05 24.7 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EDK41062.2 - 1.8e-05 24.7 0.0 2.7e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EDK41062.2 - 3.5e-05 23.6 0.0 4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EDK41062.2 - 0.00011 21.2 0.0 0.00013 21.1 0.0 1.0 1 0 0 1 1 1 1 Phosducin Redoxin PF08534.10 EDK41062.2 - 0.00029 20.6 0.0 0.00037 20.2 0.0 1.3 1 1 0 1 1 1 1 Redoxin DIM1 PF02966.16 EDK41062.2 - 0.00036 20.3 0.2 0.001 18.9 0.2 1.6 1 1 0 1 1 1 1 Mitosis protein DIM1 Glutaredoxin PF00462.24 EDK41062.2 - 0.0005 20.2 0.1 0.00081 19.6 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin OST3_OST6 PF04756.13 EDK41062.2 - 0.00073 19.0 0.0 0.00077 18.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_5 PF13743.6 EDK41062.2 - 0.0039 16.9 0.2 0.14 11.8 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin DUF836 PF05768.14 EDK41062.2 - 0.021 15.2 0.0 0.032 14.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_7 PF13899.6 EDK41062.2 - 0.026 14.7 0.2 0.077 13.2 0.2 1.8 1 1 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 EDK41062.2 - 0.062 13.3 0.0 0.069 13.1 0.0 1.3 1 1 0 1 1 1 0 Hydrogenase-1 expression protein HyaE FmdA_AmdA PF03069.15 EDK41063.1 - 4.4e-169 562.2 0.0 5.1e-169 562.0 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family Ferric_reduct PF01794.19 EDK41064.2 - 6.4e-18 65.1 6.1 6.4e-18 65.1 6.1 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDK41064.2 - 2.4e-07 30.8 0.0 4.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain DUF4405 PF14358.6 EDK41064.2 - 0.0057 17.2 8.0 0.24 12.0 0.2 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF4405) ApbA_C PF08546.11 EDK41065.1 - 2.9e-28 98.6 0.3 7.1e-28 97.3 0.4 1.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDK41065.1 - 0.048 13.3 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AA_permease PF00324.21 EDK41066.1 - 6.8e-72 242.6 41.7 7.9e-72 242.4 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK41066.1 - 3.5e-28 98.6 44.3 4.3e-28 98.3 44.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF5373 PF17343.2 EDK41066.1 - 3.2 7.6 18.1 0.053 13.4 4.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5373) TauD PF02668.16 EDK41067.1 - 1.5e-54 185.6 0.1 1.9e-54 185.3 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EDK41068.2 - 5.6e-31 107.7 25.4 2.1e-30 105.9 26.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF5353 PF17304.2 EDK41068.2 - 0.068 12.9 1.9 0.89 9.3 0.2 3.0 2 1 0 2 2 2 0 Family of unknown function (DUF5353) Plug_translocon PF10559.9 EDK41068.2 - 0.54 10.2 3.5 7.3 6.5 0.3 2.9 2 0 0 2 2 2 0 Plug domain of Sec61p AAT PF03417.16 EDK41069.2 - 5.4e-26 91.7 0.0 8e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Acetyltransf_11 PF13720.6 EDK41069.2 - 0.029 14.8 0.0 0.084 13.3 0.0 1.8 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Fungal_trans PF04082.18 EDK41070.2 - 3.1e-12 46.1 4.8 4.9e-12 45.5 4.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 EDK41071.2 - 1.3e-46 159.3 0.0 1.9e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cylicin_N PF15241.6 EDK41071.2 - 0.087 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Cylicin N-terminus adh_short_C2 PF13561.6 EDK41072.1 - 4.4e-38 131.2 0.0 9.8e-38 130.0 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41072.1 - 4e-34 117.8 0.2 5.9e-34 117.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41072.1 - 2.6e-08 34.0 2.7 3.6e-07 30.3 0.4 2.2 1 1 1 2 2 2 1 KR domain DUF1776 PF08643.10 EDK41072.1 - 0.0015 18.0 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EDK41072.1 - 0.0052 16.0 0.0 0.0071 15.5 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDK41072.1 - 0.16 11.4 0.2 0.96 8.8 0.2 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Thioredoxin_12 PF18400.1 EDK41073.2 - 0.071 12.9 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Amidohydro_1 PF01979.20 EDK41074.2 - 6.1e-12 45.5 0.1 1.5e-11 44.2 0.1 1.8 1 1 0 1 1 1 1 Amidohydrolase family LRR_4 PF12799.7 EDK41075.2 - 1.3e-08 35.0 40.8 0.00052 20.4 0.3 9.1 6 1 3 10 10 10 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK41075.2 - 0.0013 18.5 0.9 0.0013 18.5 0.9 7.9 6 2 3 9 9 9 5 Leucine rich repeat LRR_6 PF13516.6 EDK41075.2 - 0.0018 18.1 4.4 31 5.0 0.0 6.8 6 0 0 6 6 6 1 Leucine Rich repeat LRR_9 PF14580.6 EDK41075.2 - 0.049 13.1 4.7 0.43 10.1 0.6 3.0 2 1 0 2 2 2 0 Leucine-rich repeat CMS1 PF14617.6 EDK41075.2 - 0.2 10.9 0.3 2.5 7.4 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit MFS_1 PF07690.16 EDK41076.2 - 5.1e-23 81.6 20.6 6.5e-23 81.2 20.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK41076.2 - 1.9e-05 24.2 6.7 1.9e-05 24.2 6.7 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_1 PF07690.16 EDK41077.2 - 8.6e-05 21.6 0.5 0.00011 21.3 0.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PH_TFIIH PF08567.11 EDK41077.2 - 0.056 13.8 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain SSrecog PF03531.14 EDK41077.2 - 0.1 12.5 0.3 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) Amidohydro_3 PF07969.11 EDK41078.2 - 5.9e-14 52.4 0.0 5.6e-08 32.7 0.0 3.6 4 0 0 4 4 4 2 Amidohydrolase family Amidohydro_1 PF01979.20 EDK41078.2 - 5.5e-12 45.7 0.0 7.2e-10 38.7 0.0 3.2 2 1 0 2 2 2 1 Amidohydrolase family Peptidase_M20 PF01546.28 EDK41079.2 - 4.1e-33 114.8 0.0 9.5e-32 110.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK41079.2 - 1.2e-09 38.0 0.0 2.3e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Fumerase PF05681.14 EDK41079.2 - 0.18 11.2 0.1 0.39 10.1 0.0 1.5 2 0 0 2 2 2 0 Fumarate hydratase (Fumerase) Amidohydro_1 PF01979.20 EDK41080.2 - 0.11 11.8 0.0 0.33 10.2 0.0 1.7 1 1 0 1 1 1 0 Amidohydrolase family DIMCO_N PF16844.5 EDK41080.2 - 0.14 12.5 0.0 3.4 8.0 0.0 2.5 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Amidohydro_3 PF07969.11 EDK41081.2 - 8.7e-15 55.1 0.1 1.6e-08 34.5 0.0 3.0 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EDK41081.2 - 1.2e-14 54.4 0.1 3.4e-11 43.1 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EDK41082.2 - 6.1e-53 180.0 32.9 1e-52 179.2 32.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK41082.2 - 5.7e-13 48.5 12.0 5.7e-13 48.5 12.0 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EDK41082.2 - 1.8e-06 26.7 8.0 1.8e-06 26.7 8.0 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDK41082.2 - 0.16 10.3 19.6 0.2 9.9 2.1 3.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Fungal_trans_2 PF11951.8 EDK41083.2 - 3.2e-14 52.6 1.0 4.3e-14 52.1 1.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_3 PF07969.11 EDK41084.2 - 4.3e-53 181.4 0.0 5e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EDK41084.2 - 1.4e-13 50.9 0.0 2.5e-11 43.5 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family MFS_1 PF07690.16 EDK41085.1 - 3.6e-26 91.9 22.0 3.6e-26 91.9 22.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK41086.2 - 5.4e-10 38.7 48.2 5.4e-10 38.7 48.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EDK41087.2 - 1.6e-35 122.7 36.9 1.6e-35 122.7 36.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EDK41088.2 - 1.5e-23 83.3 26.1 1.5e-23 83.3 26.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 EDK41089.2 - 3.1e-13 49.9 0.1 5.8e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK41089.2 - 8.8e-05 22.4 0.9 0.00078 19.3 0.4 2.7 3 1 1 4 4 4 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDK41089.2 - 0.014 16.4 0.0 0.039 15.0 0.0 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK41090.1 - 7.5e-27 93.4 2.0 1.6e-26 92.3 2.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK41090.1 - 9.7e-19 67.6 0.0 1.6e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDK41090.1 - 6.6e-06 25.6 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDK41090.1 - 2.4e-05 23.8 0.1 4.9e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EDK41090.1 - 0.0015 19.6 0.0 0.0025 18.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 EDK41090.1 - 0.017 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase DZR PF12773.7 EDK41090.1 - 0.017 15.1 0.2 0.038 14.0 0.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon MR_MLE_C PF13378.6 EDK41091.1 - 7.2e-52 176.1 0.0 1.1e-51 175.5 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EDK41091.1 - 0.00092 19.4 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EDK41091.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Sugar_tr PF00083.24 EDK41092.2 - 8.6e-94 314.9 24.8 1e-93 314.7 24.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41092.2 - 9.4e-25 87.3 15.3 9.4e-25 87.3 15.3 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily CCB1 PF12046.8 EDK41092.2 - 0.057 12.8 0.6 5.5 6.3 0.3 2.3 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B PspC PF04024.12 EDK41092.2 - 4.5 7.2 9.2 2.9 7.8 1.7 2.7 2 0 0 2 2 2 0 PspC domain Adeno_shaft PF00608.17 EDK41093.2 - 0.022 14.5 0.1 0.14 12.0 0.1 2.1 2 0 0 2 2 2 0 Adenoviral fibre protein (repeat/shaft region) Fungal_trans PF04082.18 EDK41094.2 - 2.1e-61 207.3 5.0 2.1e-61 207.3 5.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EDK41094.2 - 1e-07 32.0 9.0 0.0032 17.8 2.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EDK41094.2 - 0.00014 22.4 2.2 0.016 15.8 0.4 2.5 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EDK41094.2 - 0.00037 21.1 7.2 0.12 13.3 0.3 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger adh_short_C2 PF13561.6 EDK41095.2 - 1.2e-39 136.3 0.1 1.4e-39 136.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41095.2 - 2.4e-36 125.0 0.2 3e-36 124.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41095.2 - 5.4e-14 52.5 0.1 6.8e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK41095.2 - 4e-08 33.4 1.3 7.6e-08 32.5 1.3 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EDK41095.2 - 3e-05 23.3 0.1 3.9e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EDK41095.2 - 4.7e-05 23.0 0.2 8.8e-05 22.1 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EDK41095.2 - 0.00092 18.8 1.7 0.004 16.8 1.4 2.0 2 1 0 2 2 2 1 NmrA-like family DUF1776 PF08643.10 EDK41095.2 - 0.0035 16.8 0.0 0.0056 16.1 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 EDK41095.2 - 0.0039 16.6 0.3 0.0066 15.9 0.3 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 EDK41095.2 - 0.03 14.6 0.1 0.1 12.8 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain adh_short PF00106.25 EDK41096.2 - 4e-35 121.1 0.1 5e-35 120.7 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK41096.2 - 9.3e-32 110.5 0.0 9.7e-32 110.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK41096.2 - 5.2e-13 49.3 0.0 6.4e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK41096.2 - 9.8e-08 32.1 0.4 2e-07 31.1 0.4 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EDK41096.2 - 0.00038 20.0 0.1 0.00085 18.8 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EDK41096.2 - 0.0023 17.4 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) TrkA_N PF02254.18 EDK41096.2 - 0.003 17.8 0.1 0.0095 16.2 0.1 1.8 2 0 0 2 2 2 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 EDK41096.2 - 0.0045 16.4 0.1 0.01 15.2 0.0 1.7 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDK41096.2 - 0.018 14.2 0.2 0.026 13.7 0.2 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.13 EDK41096.2 - 0.058 12.9 0.8 0.95 9.0 0.4 2.1 1 1 1 2 2 2 0 NmrA-like family DUF3866 PF12982.7 EDK41096.2 - 0.092 11.8 0.1 0.17 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3866) Peripla_BP_6 PF13458.6 EDK41096.2 - 0.15 11.7 0.0 8.2 6.0 0.0 2.0 1 1 1 2 2 2 0 Periplasmic binding protein DUF3589 PF12141.8 EDK41097.2 - 2e-90 303.7 0.1 4.6e-88 296.0 0.1 2.5 1 1 0 1 1 1 1 Beta-mannosyltransferases zf-MYND PF01753.18 EDK41097.2 - 0.2 11.8 0.1 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 MYND finger Sugar_tr PF00083.24 EDK41098.1 - 3.2e-153 510.8 33.6 3.7e-153 510.6 33.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41098.1 - 3.6e-26 91.9 47.2 2.5e-21 76.0 21.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 EDK41099.2 - 1.3e-21 77.6 0.0 1.9e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EDK41099.2 - 0.00059 20.5 0.0 0.0009 19.9 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain PhyH PF05721.13 EDK41100.1 - 6.7e-14 52.7 0.0 2.6e-13 50.7 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AraC_binding PF02311.19 EDK41100.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 AraC-like ligand binding domain Zn_clus PF00172.18 EDK41101.2 - 2.3e-05 24.4 10.0 6e-05 23.1 10.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EDK41102.2 - 3.8e-06 26.9 10.3 3.8e-06 26.9 10.3 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EDK41103.2 - 2e-06 27.8 7.8 3.7e-06 26.9 7.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.29 EDK41104.2 - 1.9e-54 184.9 0.0 2.5e-53 181.2 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDK41104.2 - 1e-22 81.2 23.6 1.4e-22 80.8 17.4 3.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MSV199 PF10553.9 EDK41104.2 - 0.2 11.9 3.4 6.9 6.9 0.3 2.8 2 0 0 2 2 2 0 MSV199 domain PMSR PF01625.21 EDK41105.1 - 1.3e-53 181.3 0.1 1.6e-53 181.0 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Hydantoinase_B PF02538.14 EDK41106.2 - 2e-205 683.1 0.1 2.9e-205 682.6 0.1 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EDK41106.2 - 1.8e-94 316.3 0.1 2.7e-94 315.7 0.1 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDK41106.2 - 5.9e-38 130.3 0.0 4.8e-36 124.1 0.0 2.7 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Fungal_trans PF04082.18 EDK41107.2 - 1.4e-12 47.2 0.8 3.3e-12 46.0 0.8 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EDK41108.2 - 1.7e-29 102.9 26.8 2.5e-29 102.3 26.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK41108.2 - 1.2e-06 28.1 5.1 1.2e-06 28.1 5.1 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF3094 PF11293.8 EDK41108.2 - 0.11 12.3 3.5 0.76 9.5 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF2109 PF09882.9 EDK41108.2 - 2.9 7.9 11.6 7.7 6.6 0.2 4.0 3 1 0 3 3 3 0 Predicted membrane protein (DUF2109) DNA_pol3_delta2 PF13177.6 EDK41109.2 - 3.7e-09 36.6 0.2 1e-08 35.1 0.2 1.8 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EDK41109.2 - 1.4e-07 32.0 0.3 4.5e-07 30.3 0.3 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDK41109.2 - 4.6e-06 27.0 0.5 0.00066 20.0 0.1 3.1 2 2 0 2 2 2 1 AAA domain Rad17 PF03215.15 EDK41109.2 - 5.6e-06 26.4 0.0 9.4e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 EDK41109.2 - 0.0013 18.5 0.0 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDK41109.2 - 0.0036 17.7 0.3 0.037 14.4 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDK41109.2 - 0.0059 16.6 0.0 0.1 12.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 EDK41109.2 - 0.01 16.0 0.0 0.34 11.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EDK41109.2 - 0.014 14.8 0.0 0.095 12.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DNA_pol3_delta PF06144.13 EDK41109.2 - 0.031 14.1 0.1 0.068 13.0 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit ABC_tran PF00005.27 EDK41109.2 - 0.039 14.5 0.0 0.13 12.8 0.0 1.9 2 1 0 2 2 2 0 ABC transporter INT_SG_DDX_CT_C PF15300.6 EDK41109.2 - 0.1 12.4 0.1 4.8 7.1 0.0 3.0 3 0 0 3 3 3 0 INTS6/SAGE1/DDX26B/CT45 C-terminus Pmp3 PF01679.17 EDK41110.2 - 9.1e-12 45.0 4.1 1.2e-11 44.7 4.1 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Snf7 PF03357.21 EDK41111.2 - 8.3e-26 90.6 18.5 8.3e-26 90.6 18.5 1.3 1 1 0 1 1 1 1 Snf7 T6SS_HCP PF05638.12 EDK41111.2 - 0.0099 16.3 0.4 0.017 15.5 0.4 1.4 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp Eno-Rase_FAD_bd PF07055.12 EDK41111.2 - 0.035 14.5 1.8 0.1 13.0 1.3 2.1 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain ZIP4_domain PF18292.1 EDK41111.2 - 0.67 9.9 6.8 0.42 10.5 0.9 2.1 1 1 1 2 2 2 0 Zinc transporter ZIP4 domain Ribosomal_L16 PF00252.18 EDK41113.1 - 1.1e-33 116.0 0.2 1.4e-33 115.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.20 EDK41114.2 - 1.8e-52 178.3 0.7 1.1e-25 90.6 0.0 2.8 2 1 1 3 3 3 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EDK41114.2 - 2.6e-24 85.5 0.0 9.9e-24 83.6 0.0 2.0 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Headcase PF16002.5 EDK41114.2 - 0.09 12.2 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Headcase protein Vwaint PF14624.6 EDK41114.2 - 0.13 12.4 0.3 0.37 11.0 0.3 1.7 1 0 0 1 1 1 0 VWA / Hh protein intein-like tRNA-synt_2 PF00152.20 EDK41114.2 - 0.29 10.2 2.3 5.3 6.0 0.0 3.0 2 2 0 3 3 3 0 tRNA synthetases class II (D, K and N) Flavodoxin_1 PF00258.25 EDK41115.2 - 4e-25 88.7 0.0 6.9e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EDK41115.2 - 1.3e-20 74.0 0.0 2.3e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EDK41115.2 - 1.1e-12 48.6 0.0 2.1e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Bromodomain PF00439.25 EDK41116.2 - 3.5e-34 116.7 2.6 1.5e-18 66.6 0.3 2.6 2 0 0 2 2 2 2 Bromodomain Glycohydro_20b2 PF14845.6 EDK41116.2 - 0.1 13.2 0.1 0.1 13.2 0.1 2.4 3 0 0 3 3 3 0 beta-acetyl hexosaminidase like MnmE_helical PF12631.7 EDK41117.2 - 3.8e-40 138.2 0.4 5.3e-40 137.8 0.4 1.2 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EDK41117.2 - 4.4e-37 126.9 0.0 9.9e-37 125.8 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EDK41117.2 - 1.3e-20 73.5 0.2 5.2e-20 71.6 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK41117.2 - 2e-10 40.4 0.0 3.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDK41117.2 - 5.2e-10 39.5 0.2 0.00067 19.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EDK41117.2 - 3.9e-07 30.3 0.6 0.019 15.0 0.0 2.6 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 EDK41117.2 - 3.6e-06 26.6 0.1 0.0008 19.0 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EDK41117.2 - 1.2e-05 24.7 0.1 2.2e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 EDK41117.2 - 0.0013 18.4 0.0 0.004 16.8 0.0 1.9 2 1 0 2 2 2 1 Ras family AAA_16 PF13191.6 EDK41117.2 - 0.0028 18.1 0.1 0.6 10.5 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain G-alpha PF00503.20 EDK41117.2 - 0.0055 15.9 1.6 0.15 11.2 0.4 2.6 2 1 0 3 3 3 1 G-protein alpha subunit Roc PF08477.13 EDK41117.2 - 0.0077 16.4 0.0 0.034 14.4 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 EDK41117.2 - 0.026 14.5 0.0 0.092 12.8 0.1 2.0 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Anp1 PF03452.14 EDK41117.2 - 0.029 13.8 0.4 0.1 12.0 0.4 1.9 1 1 0 1 1 1 0 Anp1 ABC_tran PF00005.27 EDK41117.2 - 0.049 14.1 2.6 0.19 12.2 2.6 2.1 1 1 0 1 1 1 0 ABC transporter ParA PF10609.9 EDK41118.1 - 5.1e-99 330.7 0.0 5.9e-99 330.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDK41118.1 - 2.6e-13 50.1 0.0 7.2e-13 48.7 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EDK41118.1 - 7.1e-10 39.1 2.3 3.4e-08 33.6 0.9 2.2 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 EDK41118.1 - 1.2e-07 31.3 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 EDK41118.1 - 5.4e-06 26.0 0.1 0.0033 16.9 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 EDK41118.1 - 7.9e-05 22.0 2.0 0.00021 20.6 0.4 2.2 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EDK41118.1 - 0.00023 21.1 2.4 0.21 11.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain CBP_BcsQ PF06564.12 EDK41118.1 - 0.00045 19.8 0.6 0.002 17.7 0.2 1.9 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 EDK41118.1 - 0.0082 15.1 0.2 0.014 14.4 0.2 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 EDK41118.1 - 0.022 14.4 0.2 0.046 13.3 0.2 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain VirC1 PF07015.11 EDK41118.1 - 0.03 13.6 0.4 0.068 12.4 0.1 1.6 2 0 0 2 2 2 0 VirC1 protein AAA_25 PF13481.6 EDK41118.1 - 0.063 12.9 0.3 0.12 12.0 0.3 1.4 1 0 0 1 1 1 0 AAA domain SPOC PF07744.13 EDK41118.1 - 0.18 11.7 0.1 8.6 6.3 0.0 2.2 2 0 0 2 2 2 0 SPOC domain CLP1_P PF16575.5 EDK41118.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop CTP_transf_1 PF01148.20 EDK41120.2 - 6e-05 22.9 4.3 0.0001 22.2 4.2 1.5 1 1 0 1 1 1 1 Cytidylyltransferase family AMMECR1 PF01871.17 EDK41121.2 - 2.6e-41 141.0 0.0 3.1e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 LRR_4 PF12799.7 EDK41122.2 - 3.5e-13 49.5 25.6 1.3e-05 25.5 4.9 5.6 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK41122.2 - 4.2e-13 48.8 21.2 9.5e-05 22.1 2.6 4.8 3 2 2 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 EDK41122.2 - 1.1e-06 28.4 22.6 0.65 10.8 0.3 7.3 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 EDK41122.2 - 3.3e-06 26.7 19.9 0.25 11.5 0.4 5.8 5 0 0 5 5 5 4 Leucine Rich repeat LRR_9 PF14580.6 EDK41122.2 - 0.021 14.3 3.2 0.25 10.8 2.1 2.4 1 1 1 2 2 2 0 Leucine-rich repeat DUF4065 PF13274.6 EDK41122.2 - 0.064 14.1 0.0 0.35 11.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) F-box-like PF12937.7 EDK41122.2 - 0.13 12.1 0.8 0.41 10.6 0.8 1.9 1 0 0 1 1 1 0 F-box-like LAMTOR PF15454.6 EDK41123.2 - 6.1e-11 42.8 6.1 6.1e-11 42.8 6.1 1.6 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator CdAMP_rec PF06153.11 EDK41123.2 - 0.075 13.2 0.2 0.15 12.3 0.1 1.5 1 1 0 1 1 1 0 Cyclic-di-AMP receptor DUF4612 PF15389.6 EDK41123.2 - 0.16 13.0 6.1 0.45 11.6 6.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4612) LMBR1 PF04791.16 EDK41124.2 - 0.22 10.4 0.6 0.28 10.0 0.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SATase_N PF06426.14 EDK41125.2 - 0.42 11.0 2.4 1.1 9.7 2.4 1.7 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal Pkinase PF00069.25 EDK41126.2 - 5.2e-67 226.0 0.0 1.7e-61 207.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41126.2 - 1.9e-34 119.1 0.0 4.4e-33 114.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EDK41126.2 - 1.6e-18 66.2 0.4 6.5e-18 64.3 0.0 2.1 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.6 EDK41126.2 - 3.5e-05 23.3 0.0 6.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDK41126.2 - 0.00019 20.9 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDK41126.2 - 0.0029 16.6 0.1 0.0029 16.6 0.1 2.4 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EDK41126.2 - 0.019 14.9 0.1 0.11 12.4 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EDK41126.2 - 0.024 14.2 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 EDK41126.2 - 0.17 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 HEXIM PF15313.6 EDK41126.2 - 5.9 7.1 12.7 24 5.1 12.7 2.1 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein Pyr_redox_2 PF07992.14 EDK41127.2 - 6e-12 45.4 0.0 9.2e-10 38.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK41127.2 - 0.0013 18.7 0.0 0.0047 16.9 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EDK41127.2 - 0.11 13.1 0.0 2.2 8.9 0.2 2.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase zf-HIT PF04438.16 EDK41128.2 - 0.017 15.0 13.8 0.026 14.4 13.8 1.3 1 0 0 1 1 1 0 HIT zinc finger DASH_Ask1 PF08655.10 EDK41129.2 - 1.4e-27 95.3 1.0 3.3e-27 94.1 1.0 1.7 1 0 0 1 1 1 1 DASH complex subunit Ask1 Complex1_LYR PF05347.15 EDK41130.2 - 7.1e-14 51.6 0.8 8.2e-14 51.4 0.8 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDK41130.2 - 0.0001 22.9 0.4 0.00013 22.6 0.4 1.1 1 0 0 1 1 1 1 Complex1_LYR-like IL28A PF15177.6 EDK41130.2 - 0.017 15.0 0.1 0.02 14.7 0.1 1.0 1 0 0 1 1 1 0 Interleukin-28A RhoGAP PF00620.27 EDK41131.2 - 1e-42 145.5 0.2 2.7e-42 144.2 0.1 1.8 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 EDK41131.2 - 3e-13 49.8 25.5 2e-08 34.3 8.0 2.5 2 0 0 2 2 2 2 LIM domain ERM PF00769.19 EDK41131.2 - 0.0022 17.9 3.5 0.0022 17.9 3.5 2.0 2 0 0 2 2 2 1 Ezrin/radixin/moesin family YabA PF06156.13 EDK41131.2 - 0.022 15.4 0.3 0.022 15.4 0.3 3.5 2 1 1 3 3 3 0 Initiation control protein YabA DUF5082 PF16888.5 EDK41131.2 - 0.069 13.4 4.6 5 7.4 1.9 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) ZapB PF06005.12 EDK41131.2 - 0.16 12.5 7.4 0.12 12.9 0.9 3.2 2 1 1 3 3 2 0 Cell division protein ZapB Filament PF00038.21 EDK41131.2 - 0.45 10.1 8.1 0.17 11.5 4.7 2.0 2 0 0 2 2 2 0 Intermediate filament protein TMF_TATA_bd PF12325.8 EDK41131.2 - 0.66 10.2 6.5 0.84 9.9 3.1 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding YhfH PF14149.6 EDK41131.2 - 1.4 9.0 8.4 19 5.3 0.1 2.9 2 0 0 2 2 2 0 YhfH-like protein APG6_N PF17675.1 EDK41131.2 - 2.4 8.7 9.0 3.1 8.3 7.2 2.2 2 0 0 2 2 1 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 EDK41131.2 - 3.6 7.6 10.3 1.8 8.6 7.1 2.2 2 1 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 EDK41131.2 - 5.3 7.5 7.1 1.8 9.0 0.7 3.0 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Glyco_transf_21 PF13506.6 EDK41132.2 - 1.2e-17 63.9 0.0 8.8e-09 35.1 0.1 3.2 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EDK41132.2 - 2.2e-12 47.4 0.0 7.3e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDK41132.2 - 3.8e-07 30.1 0.0 0.00031 20.6 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Carn_acyltransf PF00755.20 EDK41133.2 - 7.9e-192 639.0 0.0 8.9e-192 638.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RFX_DNA_binding PF02257.15 EDK41134.2 - 2e-14 54.0 0.0 4.5e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain DUF3131 PF11329.8 EDK41134.2 - 0.0077 15.4 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3131) Vac14_Fig4_bd PF11916.8 EDK41134.2 - 0.3 10.7 3.4 0.2 11.3 0.5 2.1 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding Pribosyl_synth PF14572.6 EDK41135.2 - 1.9e-39 135.6 2.7 2e-35 122.5 0.8 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDK41135.2 - 4.2e-38 129.9 1.6 2.6e-37 127.3 0.1 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDK41135.2 - 1.8e-16 60.1 1.2 3.5e-16 59.1 0.6 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDK41135.2 - 0.00036 20.0 0.1 0.00063 19.3 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF2007 PF09413.10 EDK41135.2 - 0.073 13.2 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein C9orf72-like PF15019.6 EDK41135.2 - 0.078 12.5 0.1 0.16 11.5 0.1 1.5 2 0 0 2 2 2 0 C9orf72-like protein family ATG11 PF10377.9 EDK41136.2 - 5.7e-40 136.4 0.8 5.7e-40 136.4 0.8 2.6 2 0 0 2 2 2 1 Autophagy-related protein 11 Baculo_PEP_C PF04513.12 EDK41136.2 - 0.045 13.8 14.2 0.12 12.4 0.0 5.2 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.6 EDK41136.2 - 0.22 11.7 0.0 0.22 11.7 0.0 4.1 4 0 0 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit Haem_degrading PF03928.14 EDK41137.2 - 9.2e-20 70.9 0.0 1.1e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading Haem_degrading PF03928.14 EDK41138.2 - 6.5e-32 110.1 0.0 7.6e-32 109.9 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading RXT2_N PF08595.11 EDK41139.2 - 6.5e-38 130.2 2.1 6.5e-38 130.2 2.1 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal DinB_2 PF12867.7 EDK41139.2 - 0.044 14.3 0.0 0.079 13.5 0.0 1.5 1 1 0 1 1 1 0 DinB superfamily PCNA_N PF00705.18 EDK41140.1 - 4.5e-49 165.4 2.4 4.5e-49 165.4 2.4 2.1 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EDK41140.1 - 7.8e-47 158.6 0.0 1.3e-46 157.9 0.0 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EDK41140.1 - 6.8e-07 29.0 0.2 8.7e-07 28.6 0.2 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EDK41140.1 - 9.1e-07 28.2 1.6 0.00012 21.2 0.6 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EDK41140.1 - 1.9e-05 23.9 0.0 0.014 14.5 0.0 2.1 2 0 0 2 2 2 2 Hus1-like protein Acetyltransf_1 PF00583.25 EDK41141.1 - 3.6e-15 56.2 0.0 4.9e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK41141.1 - 9.1e-11 42.0 0.0 1.4e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDK41141.1 - 6e-10 39.9 0.0 7.3e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK41141.1 - 9e-10 38.6 0.0 1.3e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK41141.1 - 6.9e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 EDK41141.1 - 1.4e-07 31.3 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK41141.1 - 0.0032 17.6 0.0 0.0058 16.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EDK41141.1 - 0.025 14.7 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EDK41141.1 - 0.027 13.9 0.0 0.089 12.3 0.0 1.6 1 1 0 1 1 1 0 Putative acetyl-transferase F_bP_aldolase PF01116.20 EDK41142.1 - 1.6e-71 241.0 0.0 2e-71 240.8 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II zf-Tim10_DDP PF02953.15 EDK41143.1 - 2.5e-16 59.1 2.6 3e-16 58.8 2.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.15 EDK41144.2 - 1.2e-63 215.1 0.3 3.1e-63 213.6 0.3 1.6 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 EDK41144.2 - 5.2e-48 163.4 0.0 1.2e-47 162.2 0.0 1.6 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EDK41144.2 - 0.00086 18.6 0.1 0.048 12.9 0.0 2.4 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 EDK41144.2 - 0.01 15.9 0.1 1 9.4 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 EDK41144.2 - 0.064 12.8 0.1 0.37 10.4 0.0 2.0 2 0 0 2 2 2 0 RimK-like ATP-grasp domain CUE PF02845.16 EDK41145.2 - 5.1e-09 35.7 0.3 7.4e-09 35.1 0.3 1.3 1 0 0 1 1 1 1 CUE domain LAP1C PF05609.12 EDK41145.2 - 0.29 10.2 12.9 0.37 9.8 12.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PDCD2_C PF04194.13 EDK41145.2 - 1.3 9.1 14.2 25 4.9 14.2 2.4 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Hid1 PF12722.7 EDK41145.2 - 7.7 4.5 15.2 9.4 4.2 15.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4551 PF15087.6 EDK41145.2 - 8 5.2 18.0 9.9 4.9 18.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MAT1 PF06391.13 EDK41146.1 - 1.6 8.6 14.7 3 7.6 14.7 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 CDC45 PF02724.14 EDK41146.1 - 6.5 4.9 11.0 9.3 4.4 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein HMG_box PF00505.19 EDK41147.1 - 7.4e-25 87.2 2.0 7.4e-25 87.2 2.0 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDK41147.1 - 6e-19 68.4 1.4 9.6e-19 67.8 1.4 1.3 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 EDK41147.1 - 0.00072 19.5 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 CHDNT (NUC034) domain HMG_box_5 PF14887.6 EDK41147.1 - 0.00095 19.1 1.5 0.00095 19.1 1.5 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box 5 Ccdc124 PF06244.12 EDK41147.1 - 0.0033 18.0 0.0 0.0033 18.0 0.0 2.0 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 YABBY PF04690.13 EDK41147.1 - 0.15 12.7 1.3 0.16 12.6 0.3 1.6 1 1 1 2 2 2 0 YABBY protein AATase PF07247.12 EDK41148.2 - 1.4e-50 172.3 0.2 3.3e-50 171.1 0.2 1.6 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EDK41148.2 - 0.22 10.1 0.2 1.8 7.2 0.0 2.4 3 1 0 3 3 3 0 Condensation domain DUF89 PF01937.19 EDK41149.1 - 7.5e-118 393.5 3.7 8.5e-118 393.3 3.7 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 TFIIA_gamma_C PF02751.14 EDK41150.2 - 5.6e-24 84.0 1.3 8.6e-24 83.4 1.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EDK41150.2 - 1.1e-22 79.7 0.4 1.8e-22 79.1 0.4 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Nup160 PF11715.8 EDK41151.2 - 1.3e-35 123.0 4.3 1.3e-35 123.0 4.3 1.6 2 0 0 2 2 2 1 Nucleoporin Nup120/160 CobA_CobO_BtuR PF02572.15 EDK41151.2 - 0.091 13.0 0.1 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF4144 PF13642.6 EDK41152.2 - 0.022 15.3 0.2 0.28 11.8 0.1 2.2 2 0 0 2 2 2 0 protein structure with unknown function zf-CCHC_2 PF13696.6 EDK41152.2 - 0.048 13.5 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF3072 PF11272.8 EDK41152.2 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) FAD_binding_2 PF00890.24 EDK41152.2 - 0.11 11.5 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Bul1_N PF04425.12 EDK41153.2 - 6.1e-160 532.9 5.5 6.1e-160 532.9 5.5 1.9 1 1 1 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 EDK41153.2 - 6.8e-14 51.9 13.5 3.3e-08 33.3 0.2 4.3 3 1 0 4 4 4 3 Bul1 C terminus GATase PF00117.28 EDK41154.2 - 7.4e-45 153.1 0.0 1.1e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EDK41154.2 - 2e-40 137.6 0.0 4e-40 136.6 0.0 1.5 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EDK41154.2 - 0.00028 20.7 0.1 0.0029 17.4 0.0 2.3 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 EDK41154.2 - 0.09 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family FA_hydroxylase PF04116.13 EDK41155.2 - 4.7e-21 75.5 22.1 4.7e-21 75.5 22.1 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily adh_short PF00106.25 EDK41156.2 - 3.4e-51 173.5 0.0 4.7e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK41156.2 - 1.9e-35 122.6 0.0 2.4e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK41156.2 - 1.6e-12 47.7 0.0 2.3e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDK41156.2 - 0.00015 21.0 0.0 0.0003 20.0 0.0 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EDK41156.2 - 0.0083 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EDK41156.2 - 0.096 12.1 0.1 0.2 11.1 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ATP_bind_3 PF01171.20 EDK41157.2 - 4.2e-18 65.7 0.0 2.9e-17 63.0 0.0 2.3 3 1 0 3 3 3 1 PP-loop family zn-ribbon_14 PF16503.5 EDK41157.2 - 4.7e-17 61.2 4.2 4.7e-17 61.2 4.2 3.7 4 0 0 4 4 4 1 Zinc-ribbon HNH PF01844.23 EDK41157.2 - 1.2 9.4 8.2 23 5.3 0.0 3.8 4 0 0 4 4 4 0 HNH endonuclease Cytochrom_c3_2 PF14537.6 EDK41157.2 - 4.6 7.8 9.2 1.1 9.8 0.7 2.6 2 0 0 2 2 2 0 Cytochrome c3 DUF2616 PF11077.8 EDK41157.2 - 6 6.5 9.0 1.2 8.8 1.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) eIF-3c_N PF05470.12 EDK41158.2 - 2.6e-147 491.7 6.7 3.5e-114 382.3 0.2 2.9 3 1 1 4 4 4 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EDK41158.2 - 1.6e-08 35.0 2.0 2.9e-08 34.2 0.2 2.5 2 1 1 3 3 3 1 PCI domain DUF4373 PF14297.6 EDK41158.2 - 0.045 14.5 0.2 2.9 8.7 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4373) MetOD2 PF18548.1 EDK41158.2 - 0.33 11.1 3.7 1.3 9.1 0.2 3.3 3 0 0 3 3 3 0 Metanogen output domain 2 MIT PF04212.18 EDK41159.2 - 0.0043 17.1 1.2 0.0052 16.8 0.2 1.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain GvpL_GvpF PF06386.11 EDK41160.2 - 0.26 11.2 3.9 0.5 10.2 0.3 2.1 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF DUF4706 PF15797.5 EDK41160.2 - 3.3 8.3 8.6 3.9 8.0 0.6 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4706) NMT_C PF02799.15 EDK41161.2 - 6.1e-80 267.7 0.6 8.3e-80 267.2 0.6 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EDK41161.2 - 3.5e-73 244.7 0.1 1.1e-72 243.1 0.0 1.8 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 EDK41161.2 - 0.0069 16.6 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family WD40 PF00400.32 EDK41162.1 - 1.1e-09 38.7 12.0 0.00029 21.6 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 EDK41162.1 - 2e-05 23.5 2.1 0.0037 16.0 1.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDK41162.1 - 0.0027 18.0 2.6 0.18 12.1 0.7 3.2 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain ABC_tran PF00005.27 EDK41163.1 - 9.9e-50 168.6 0.4 7.5e-24 84.8 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EDK41163.1 - 3.3e-21 75.1 1.0 3.3e-21 75.1 1.0 3.4 4 1 0 4 4 1 1 ABC transporter AAA_21 PF13304.6 EDK41163.1 - 7.7e-19 68.6 0.6 1.7e-05 24.8 0.1 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDK41163.1 - 4.9e-10 39.2 1.9 0.11 11.9 0.0 4.6 4 1 1 5 5 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDK41163.1 - 1.3e-07 31.2 0.0 0.0067 16.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDK41163.1 - 1.6e-07 31.8 0.1 0.0017 18.7 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDK41163.1 - 6.9e-07 29.3 0.2 0.0027 17.6 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase AAA_22 PF13401.6 EDK41163.1 - 7e-07 29.6 0.1 0.02 15.2 0.0 3.0 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 EDK41163.1 - 1.7e-05 24.8 0.3 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.6 EDK41163.1 - 2.8e-05 24.0 5.3 0.031 14.0 0.0 3.8 4 1 0 5 5 4 2 AAA ATPase domain AAA_23 PF13476.6 EDK41163.1 - 3.3e-05 24.5 14.8 0.13 12.8 0.0 4.3 4 0 0 4 4 3 2 AAA domain AAA_18 PF13238.6 EDK41163.1 - 5.8e-05 23.6 0.1 0.084 13.4 0.0 3.2 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 EDK41163.1 - 6.4e-05 23.3 0.0 0.81 10.1 0.0 2.9 2 0 0 2 2 2 2 RNA helicase MMR_HSR1 PF01926.23 EDK41163.1 - 8.8e-05 22.6 0.0 0.17 12.0 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 EDK41163.1 - 0.00011 22.6 0.0 0.83 10.1 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDK41163.1 - 0.00013 22.2 0.8 0.28 11.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EDK41163.1 - 0.00016 21.7 0.1 0.53 10.3 0.1 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EDK41163.1 - 0.00018 20.8 0.0 0.91 8.7 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain Roc PF08477.13 EDK41163.1 - 0.00018 21.7 0.0 0.32 11.2 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EDK41163.1 - 0.0002 21.4 0.0 1.3 9.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EDK41163.1 - 0.00024 20.9 0.4 0.33 10.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain MCM PF00493.23 EDK41163.1 - 0.00094 18.3 0.0 0.28 10.3 0.0 2.5 2 0 0 2 2 2 1 MCM P-loop domain AAA_33 PF13671.6 EDK41163.1 - 0.0016 18.6 3.3 0.52 10.5 0.0 3.3 4 0 0 4 4 2 1 AAA domain AAA_7 PF12775.7 EDK41163.1 - 0.0022 17.5 0.1 0.42 10.1 0.0 2.7 3 0 0 3 3 2 1 P-loop containing dynein motor region DUF815 PF05673.13 EDK41163.1 - 0.003 16.7 0.0 1 8.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) G-alpha PF00503.20 EDK41163.1 - 0.0037 16.5 0.4 1.6 7.8 0.0 3.2 2 2 1 3 3 3 1 G-protein alpha subunit AAA_30 PF13604.6 EDK41163.1 - 0.0052 16.5 0.1 0.53 10.0 0.0 3.3 3 1 0 3 3 2 1 AAA domain AAA_25 PF13481.6 EDK41163.1 - 0.006 16.2 0.0 2.1 7.9 0.0 3.5 3 1 0 3 3 3 1 AAA domain TsaE PF02367.17 EDK41163.1 - 0.0073 16.3 0.3 15 5.6 0.0 3.5 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ras PF00071.22 EDK41163.1 - 0.0078 15.8 0.1 5 6.7 0.0 2.8 3 0 0 3 3 3 0 Ras family NTPase_1 PF03266.15 EDK41163.1 - 0.019 14.9 0.1 1.7 8.6 0.0 2.6 2 0 0 2 2 2 0 NTPase Rad17 PF03215.15 EDK41163.1 - 0.02 14.9 0.0 6.8 6.6 0.0 2.6 3 0 0 3 3 2 0 Rad17 P-loop domain PduV-EutP PF10662.9 EDK41163.1 - 0.032 14.0 0.4 17 5.1 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DAP3 PF10236.9 EDK41163.1 - 0.087 12.0 1.4 5.4 6.1 0.0 2.6 3 0 0 3 3 2 0 Mitochondrial ribosomal death-associated protein 3 MeaB PF03308.16 EDK41163.1 - 0.092 11.7 0.0 7.6 5.4 0.0 2.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TIR-like PF10137.9 EDK41163.1 - 0.13 12.3 0.1 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain ATPase_2 PF01637.18 EDK41163.1 - 0.26 11.2 6.6 1.5 8.7 0.0 3.2 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EDK41163.1 - 0.66 10.4 5.6 29 5.1 0.0 4.0 4 0 0 4 4 3 0 AAA domain NARP1 PF12569.8 EDK41163.1 - 0.92 8.3 8.9 1.6 7.6 8.9 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FYDLN_acid PF09538.10 EDK41163.1 - 1.3 9.7 7.9 3.4 8.4 7.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF87 PF01935.17 EDK41163.1 - 1.5 8.9 9.6 19 5.2 0.1 4.0 4 1 1 5 5 4 0 Helicase HerA, central domain Dynamin_N PF00350.23 EDK41163.1 - 1.8 8.6 9.5 11 6.0 0.0 4.1 3 1 1 4 4 4 0 Dynamin family AAA_27 PF13514.6 EDK41163.1 - 2.5 7.7 0.0 2.5 7.7 0.0 3.3 4 0 0 4 4 2 0 AAA domain BLM10_mid PF16507.5 EDK41164.2 - 6e-173 576.3 3.5 1.1e-172 575.3 3.5 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 EDK41164.2 - 8.5e-31 106.1 0.6 4.4e-30 103.8 0.3 2.5 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 EDK41164.2 - 1.8e-25 88.7 0.0 7.3e-25 86.7 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) DUF4268 PF14088.6 EDK41164.2 - 0.036 13.9 0.5 0.21 11.5 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4268) PBP1_TM PF14812.6 EDK41164.2 - 0.81 10.1 4.2 3 8.3 4.2 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EF-hand_1 PF00036.32 EDK41165.2 - 6.9e-13 47.2 0.5 0.00047 19.5 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 EDK41165.2 - 4.9e-12 44.8 0.6 4.4e-05 22.8 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EDK41165.2 - 2.8e-11 42.4 1.9 0.0055 16.5 0.0 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EDK41165.2 - 2.3e-09 37.6 0.3 0.0019 18.6 0.3 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDK41165.2 - 0.005 16.7 3.4 2.7 7.9 0.0 3.8 5 0 0 5 5 5 2 EF-hand domain pair Toprim_2 PF13155.6 EDK41165.2 - 0.17 12.3 0.0 0.62 10.5 0.0 1.9 2 0 0 2 2 2 0 Toprim-like Glycos_transf_2 PF00535.26 EDK41167.2 - 0.096 12.5 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Septin PF00735.18 EDK41168.1 - 6.9e-75 251.9 0.0 1.1e-74 251.2 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EDK41168.1 - 6.1e-06 26.3 0.0 1.8e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EDK41168.1 - 0.0016 17.8 0.0 0.0049 16.2 0.0 1.7 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EDK41168.1 - 0.0021 18.0 0.0 0.14 12.0 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EDK41168.1 - 0.011 15.1 0.1 0.062 12.6 0.0 2.4 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EDK41168.1 - 0.016 15.7 1.3 0.08 13.4 0.0 2.3 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 EDK41168.1 - 0.017 15.5 0.0 0.053 13.9 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain NucS PF01939.16 EDK41168.1 - 0.025 13.9 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 Endonuclease NucS Ras PF00071.22 EDK41168.1 - 0.033 13.8 0.1 0.38 10.3 0.0 2.4 2 0 0 2 2 2 0 Ras family Dynamin_N PF00350.23 EDK41168.1 - 0.049 13.7 1.1 0.77 9.8 0.0 2.9 3 1 0 3 3 3 0 Dynamin family cobW PF02492.19 EDK41168.1 - 0.092 12.3 0.1 1.2 8.7 0.0 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EDK41168.1 - 0.092 13.0 0.0 0.46 10.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EDK41168.1 - 0.11 11.9 0.1 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.6 EDK41168.1 - 0.13 12.4 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK41168.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EDK41168.1 - 0.25 11.6 3.1 1.4 9.2 0.1 3.1 2 1 1 3 3 3 0 AAA domain AAA_23 PF13476.6 EDK41168.1 - 0.6 10.6 4.0 6 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain PIN_4 PF13638.6 EDK41169.1 - 5.6e-07 29.9 0.0 6.5e-06 26.5 0.0 2.2 1 1 0 1 1 1 1 PIN domain QLQ PF08880.11 EDK41170.2 - 2.8e-11 43.0 3.8 2.8e-11 43.0 3.8 5.1 6 0 0 6 6 6 1 QLQ HSA PF07529.13 EDK41170.2 - 7.5e-08 32.6 10.9 7.5e-08 32.6 10.9 3.0 2 0 0 2 2 2 1 HSA SNF2_N PF00176.23 EDK41171.2 - 2e-73 247.2 0.6 2.8e-73 246.6 0.6 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDK41171.2 - 1.2e-20 73.9 0.0 4.2e-19 68.9 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 EDK41171.2 - 9.5e-15 55.0 0.5 9.5e-15 55.0 0.5 2.6 1 1 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 EDK41171.2 - 3.9e-09 36.7 1.5 7.5e-09 35.8 0.1 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK41171.2 - 3.9e-07 29.5 0.2 1.1e-06 28.1 0.2 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EDK41171.2 - 2.1e-05 24.3 0.0 4.9e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase PcfJ PF14284.6 EDK41171.2 - 0.047 13.6 1.8 2.8 7.8 0.0 3.2 3 0 0 3 3 3 0 PcfJ-like protein RrnaAD PF00398.20 EDK41172.2 - 7.8e-32 110.4 0.0 1.1e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase RICTOR_M PF14666.6 EDK41172.2 - 0.013 15.3 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Methyltransf_32 PF13679.6 EDK41172.2 - 0.029 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Vps36_ESCRT-II PF11605.8 EDK41173.2 - 0.00017 21.7 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 EDK41173.2 - 0.041 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain Suf PF05843.14 EDK41174.2 - 1.5e-54 186.0 24.6 1.1e-48 166.7 7.8 4.5 4 2 2 6 6 6 3 Suppressor of forked protein (Suf) DUF4924 PF16271.5 EDK41174.2 - 0.021 14.9 1.0 0.082 12.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4924) TPR_17 PF13431.6 EDK41174.2 - 0.042 14.2 0.0 7.1 7.2 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF835 PF05763.12 EDK41174.2 - 0.054 13.2 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF835) PKK PF12474.8 EDK41174.2 - 0.084 13.0 0.3 0.084 13.0 0.3 2.2 2 0 0 2 2 2 0 Polo kinase kinase TPR_19 PF14559.6 EDK41174.2 - 0.14 12.7 0.0 20 5.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat YlbD_coat PF14071.6 EDK41174.2 - 0.2 11.9 9.1 0.11 12.7 1.2 2.9 3 0 0 3 3 3 0 Putative coat protein GAS PF13851.6 EDK41174.2 - 1.1 8.5 19.7 3.1 7.1 2.7 3.3 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding RecG_N PF17190.4 EDK41174.2 - 1.2 9.9 6.5 4.8 8.0 0.7 4.0 3 1 0 4 4 4 0 RecG N-terminal helical domain Tom37 PF10568.9 EDK41175.2 - 3.2e-29 101.8 0.2 6.7e-29 100.7 0.2 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Tom37_C PF11801.8 EDK41175.2 - 6.5e-06 26.2 0.2 1.7e-05 24.8 0.1 1.7 2 0 0 2 2 2 1 Tom37 C-terminal domain GST_N_4 PF17172.4 EDK41175.2 - 0.011 16.4 0.0 0.025 15.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF4448 PF14610.6 EDK41176.2 - 2.3e-58 197.1 0.2 2.3e-58 197.1 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) Zip PF02535.22 EDK41177.2 - 3.8e-26 92.1 10.0 2.7e-16 59.7 5.4 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter PNRC PF15365.6 EDK41178.2 - 7e-07 28.9 5.2 7e-07 28.9 5.2 2.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif Cation_efflux PF01545.21 EDK41179.2 - 7.6e-56 189.0 1.6 1.1e-55 188.5 1.6 1.2 1 0 0 1 1 1 1 Cation efflux family Histone_HNS PF00816.21 EDK41179.2 - 0.12 13.3 0.1 0.26 12.1 0.1 1.5 1 0 0 1 1 1 0 H-NS histone family DUF2157 PF09925.9 EDK41179.2 - 0.53 10.1 3.3 7.4 6.4 0.4 2.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) PY_rept_46 PF09689.10 EDK41181.2 - 0.024 15.2 7.5 0.024 15.2 7.5 2.9 2 0 0 2 2 2 0 Plasmodium yoelii repeat (PY_rept_46) Opi1 PF08618.10 EDK41182.2 - 1.4e-19 70.7 20.6 9e-08 31.8 0.1 3.8 2 1 2 4 4 4 3 Transcription factor Opi1 DNA_pol3_a_NII PF11490.8 EDK41182.2 - 0.014 15.2 2.9 0.04 13.8 2.9 1.7 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II VGPC1_C PF16799.5 EDK41182.2 - 0.33 11.0 6.2 0.18 11.8 3.5 2.0 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Spore_II_R PF09551.10 EDK41182.2 - 6.7 7.2 7.0 62 4.1 0.1 2.8 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) PTR2 PF00854.21 EDK41183.1 - 1.6e-93 313.7 17.0 4.2e-93 312.3 15.5 2.1 1 1 0 1 1 1 1 POT family S1 PF00575.23 EDK41184.2 - 2.3e-64 213.7 42.9 3.1e-14 53.1 1.2 13.1 13 0 0 13 13 13 11 S1 RNA binding domain Suf PF05843.14 EDK41184.2 - 4.1e-07 30.3 2.5 4.1e-07 30.3 2.5 4.4 2 1 2 4 4 4 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EDK41184.2 - 1.1e-05 25.8 0.1 0.58 10.7 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDK41184.2 - 0.00075 20.1 0.0 0.82 10.7 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK41184.2 - 0.036 13.3 5.8 0.61 9.3 1.6 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF5334 PF17268.2 EDK41184.2 - 0.22 11.8 1.9 4.7 7.6 0.1 3.3 2 0 0 2 2 2 0 Family of unknown function (DUF5334) BRAP2 PF07576.12 EDK41185.2 - 3e-31 107.6 0.1 6.4e-31 106.5 0.1 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EDK41185.2 - 7.2e-19 67.9 4.6 1.8e-18 66.6 4.6 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EDK41185.2 - 5.6e-08 33.0 10.6 5.6e-08 33.0 10.6 2.1 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EDK41185.2 - 9.2e-06 25.6 4.3 9.2e-06 25.6 4.3 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDK41185.2 - 1.4e-05 24.8 10.6 1.4e-05 24.8 10.6 2.1 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDK41185.2 - 7.3e-05 22.4 4.8 7.3e-05 22.4 4.8 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EDK41185.2 - 9.1e-05 22.2 6.3 9.1e-05 22.2 6.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDK41185.2 - 0.00016 21.5 8.2 0.00016 21.5 8.2 2.1 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDK41185.2 - 0.00022 21.4 7.1 0.00022 21.4 7.1 2.3 2 1 1 3 3 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK41185.2 - 0.00064 19.5 10.3 0.00064 19.5 10.3 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) CALCOCO1 PF07888.11 EDK41185.2 - 0.0016 17.4 9.1 0.0023 16.9 9.1 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.12 EDK41185.2 - 0.0098 16.3 7.2 0.035 14.6 2.6 2.5 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 EDK41185.2 - 0.029 14.8 5.6 0.31 11.5 0.6 2.8 1 1 1 2 2 2 0 Cell division protein ZapB DUF5082 PF16888.5 EDK41185.2 - 0.031 14.6 8.4 0.21 11.9 0.5 2.7 2 1 1 3 3 2 0 Domain of unknown function (DUF5082) TerY_C PF15616.6 EDK41185.2 - 0.035 14.2 1.0 0.035 14.2 1.0 2.4 2 0 0 2 2 2 0 TerY-C metal binding domain Corona_NSP4_C PF16348.5 EDK41185.2 - 0.13 13.0 0.1 0.38 11.6 0.1 1.8 1 0 0 1 1 1 0 Coronavirus nonstructural protein 4 C-terminus bZIP_1 PF00170.21 EDK41185.2 - 0.21 11.7 6.2 0.6 10.3 1.4 3.0 2 0 0 2 2 2 0 bZIP transcription factor DUF641 PF04859.12 EDK41185.2 - 0.25 11.7 5.9 0.092 13.1 1.8 2.3 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) zf-C3HC4_4 PF15227.6 EDK41185.2 - 0.33 11.2 7.5 1.8 8.8 7.5 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Spc7 PF08317.11 EDK41185.2 - 0.39 9.5 11.3 0.029 13.3 6.4 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 EDK41185.2 - 0.45 10.6 2.4 1 9.4 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EDK41185.2 - 0.86 10.3 6.2 0.2 12.3 1.5 2.5 2 1 0 2 2 1 0 SlyX YabA PF06156.13 EDK41185.2 - 1.6 9.4 7.9 0.36 11.5 2.7 2.5 2 1 1 3 3 2 0 Initiation control protein YabA Prok-RING_4 PF14447.6 EDK41185.2 - 1.6 8.6 22.7 0.34 10.8 12.2 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDK41185.2 - 1.9 8.6 11.2 0.057 13.5 4.5 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DivIC PF04977.15 EDK41185.2 - 2 8.2 8.3 1.2 8.9 1.3 3.1 1 1 2 3 3 3 0 Septum formation initiator GIT_CC PF16559.5 EDK41185.2 - 3 7.8 13.7 15 5.5 0.1 3.2 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Seryl_tRNA_N PF02403.22 EDK41185.2 - 3.7 7.8 11.7 4.7 7.5 3.4 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 EDK41185.2 - 4 7.9 7.0 5.6 7.4 0.7 3.3 2 1 1 3 3 2 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 EDK41186.2 - 2.9e-66 223.6 0.0 8.5e-64 215.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41186.2 - 1.1e-47 162.5 0.0 1.9e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK41186.2 - 4e-05 22.6 1.6 0.0009 18.1 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDK41186.2 - 0.0075 15.6 0.0 0.017 14.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like ADH_zinc_N PF00107.26 EDK41187.2 - 2.6e-25 88.9 1.4 5.4e-25 87.9 1.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDK41187.2 - 5.1e-23 81.0 0.0 1.3e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EDK41187.2 - 5.7e-07 30.7 0.1 1.6e-06 29.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.16 EDK41187.2 - 0.029 15.0 0.0 0.058 14.0 0.0 1.6 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II NMO PF03060.15 EDK41187.2 - 0.057 12.8 0.1 0.091 12.1 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase SIS_2 PF13580.6 EDK41187.2 - 0.43 10.6 2.5 0.26 11.3 0.5 1.6 2 0 0 2 2 2 0 SIS domain ADH_zinc_N PF00107.26 EDK41188.1 - 3.9e-28 98.0 0.8 7.8e-28 97.0 0.8 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDK41188.1 - 2.1e-23 82.3 0.0 4.4e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EDK41188.1 - 3.4e-08 34.6 0.1 1.5e-07 32.6 0.0 2.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase NMO PF03060.15 EDK41188.1 - 0.055 12.8 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase SIS_2 PF13580.6 EDK41188.1 - 0.14 12.2 0.6 0.77 9.8 0.3 2.1 2 0 0 2 2 2 0 SIS domain ADH_zinc_N PF00107.26 EDK41189.2 - 2.7e-26 92.1 0.1 4.6e-26 91.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EDK41189.2 - 5.5e-25 87.4 0.1 9.8e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EDK41189.2 - 1.2e-06 29.6 0.0 3.6e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.16 EDK41189.2 - 0.066 13.8 0.1 0.16 12.6 0.1 1.7 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ADH_N_2 PF16884.5 EDK41190.1 - 1.2e-20 73.4 0.0 2.1e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EDK41190.1 - 0.0043 17.0 0.9 0.0071 16.3 0.9 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SIS_2 PF13580.6 EDK41190.1 - 0.02 14.9 0.1 0.029 14.4 0.1 1.3 1 0 0 1 1 1 0 SIS domain CDC50 PF03381.15 EDK41191.2 - 7.8e-92 307.7 3.1 9.8e-92 307.4 3.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family eRF1_2 PF03464.15 EDK41192.1 - 1.5e-46 158.0 0.1 2.8e-46 157.1 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDK41192.1 - 2.1e-36 124.8 0.2 4.6e-36 123.7 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDK41192.1 - 1.2e-20 73.8 0.0 2e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EDK41192.1 - 1.5e-10 41.5 0.0 2.3e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EDK41192.1 - 8e-10 39.1 0.1 1.2e-09 38.5 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor DUF3440 PF11922.8 EDK41192.1 - 0.035 13.8 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) PTSIIB_sorb PF03830.15 EDK41192.1 - 0.051 13.8 0.9 0.11 12.7 0.1 2.0 3 1 0 3 3 3 0 PTS system sorbose subfamily IIB component Tnp_DNA_bind PF14706.6 EDK41192.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Transposase DNA-binding DEAD PF00270.29 EDK41193.1 - 3.9e-39 134.2 0.0 7.9e-39 133.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK41193.1 - 1.4e-27 96.3 0.0 3.3e-26 91.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41193.1 - 5.5e-07 29.8 0.8 1.1e-06 28.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDK41193.1 - 0.025 14.8 0.6 0.025 14.8 0.6 2.2 2 1 0 2 2 2 0 AAA domain Nop25 PF09805.9 EDK41193.1 - 1.7 9.1 15.0 0.25 11.8 10.0 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Bmt2 PF11968.8 EDK41194.2 - 1.3e-92 309.6 0.2 2.8e-92 308.5 0.1 1.5 2 0 0 2 2 2 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EDK41194.2 - 1.2e-07 31.8 0.0 2.1e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK41194.2 - 0.0029 18.3 0.0 0.29 11.9 0.0 3.5 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK41194.2 - 0.0087 16.7 0.0 0.14 12.8 0.0 2.7 2 1 1 3 3 3 1 Methyltransferase domain TraI_2_C PF07515.11 EDK41194.2 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Putative conjugal transfer nickase/helicase TraI C-term Mer2 PF09074.10 EDK41194.2 - 0.046 13.5 1.7 0.55 10.0 0.4 2.3 2 0 0 2 2 2 0 Mer2 Sugar_tr PF00083.24 EDK41195.2 - 9e-161 535.7 27.3 1e-160 535.5 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41195.2 - 8.3e-33 113.8 23.9 2.4e-28 99.1 12.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK41195.2 - 0.00024 19.6 0.6 0.00024 19.6 0.6 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Ni_hydr_CYTB PF01292.20 EDK41195.2 - 0.092 12.3 6.5 0.59 9.7 3.0 3.0 3 1 0 3 3 3 0 Prokaryotic cytochrome b561 DUF4293 PF14126.6 EDK41195.2 - 0.56 10.5 8.4 0.3 11.3 1.5 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) MpPF26 PF07666.11 EDK41195.2 - 8.2 6.6 9.3 2.9 8.0 0.5 3.3 2 1 0 2 2 2 0 M penetrans paralogue family 26 Aminotran_1_2 PF00155.21 EDK41196.1 - 5.3e-80 269.3 0.0 6e-80 269.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PGM_PMM_I PF02878.16 EDK41197.2 - 3.2e-37 127.3 0.2 4.7e-37 126.8 0.2 1.2 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDK41197.2 - 6.9e-24 84.2 0.0 2.2e-23 82.6 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EDK41197.2 - 6e-14 52.5 0.0 1.4e-13 51.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EDK41197.2 - 1.2e-10 41.4 0.0 2.8e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain GATA PF00320.27 EDK41198.2 - 9.3e-15 53.9 4.5 2e-14 52.9 4.5 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDK41198.2 - 0.0029 17.1 0.5 0.0052 16.3 0.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Pox_A_type_inc PF04508.12 EDK41198.2 - 0.012 15.4 1.2 6.3 6.8 0.2 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Auto_anti-p27 PF06677.12 EDK41198.2 - 0.52 10.5 1.5 0.9 9.7 1.5 1.3 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Vfa1 PF08432.10 EDK41198.2 - 0.89 9.9 7.3 0.045 14.1 1.3 1.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Ribosomal_S15 PF00312.22 EDK41199.2 - 9.4e-27 93.0 0.2 9.4e-27 93.0 0.2 2.6 3 0 0 3 3 3 1 Ribosomal protein S15 Nnf1 PF03980.14 EDK41200.2 - 2.5e-26 92.2 1.0 4.1e-26 91.5 1.0 1.4 1 0 0 1 1 1 1 Nnf1 DUF4476 PF14771.6 EDK41200.2 - 0.01 16.1 0.2 0.019 15.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Vps53_N PF04100.12 EDK41200.2 - 0.025 13.6 3.2 0.19 10.7 0.1 2.1 2 0 0 2 2 2 0 Vps53-like, N-terminal HALZ PF02183.18 EDK41200.2 - 0.047 13.9 0.5 0.047 13.9 0.5 2.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper SNAP PF14938.6 EDK41201.2 - 4.3e-109 364.3 8.1 4.9e-109 364.1 8.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 EDK41201.2 - 7e-08 32.0 8.0 0.056 13.6 0.3 5.3 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDK41201.2 - 3e-07 30.0 2.2 0.02 14.9 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDK41201.2 - 2.2e-06 27.9 4.5 0.0063 16.8 0.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDK41201.2 - 3.4e-06 26.8 6.7 0.44 10.9 0.0 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK41201.2 - 6.9e-06 25.7 0.1 4e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 EDK41201.2 - 4e-05 23.2 12.0 0.32 10.9 0.0 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDK41201.2 - 4.8e-05 23.9 1.5 0.026 15.2 0.0 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDK41201.2 - 8e-05 23.2 1.0 1.6 9.7 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK41201.2 - 0.00011 22.6 3.0 0.17 12.6 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.9 EDK41201.2 - 0.0017 18.1 0.7 0.28 10.9 0.0 3.2 1 1 2 3 3 3 1 26S proteasome subunit RPN7 MIT PF04212.18 EDK41201.2 - 0.016 15.2 9.4 0.64 10.1 0.1 4.7 1 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3206 PF11472.8 EDK41201.2 - 0.054 13.5 0.4 0.15 12.0 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) ANAPC3 PF12895.7 EDK41201.2 - 0.073 13.3 11.0 0.42 10.9 0.6 3.8 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EDK41201.2 - 0.08 13.2 0.1 23 5.5 0.0 4.2 5 0 0 5 5 4 0 PPR repeat NSF PF02071.20 EDK41201.2 - 0.081 13.7 15.1 1.9 9.6 0.1 6.2 7 0 0 7 7 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_10 PF13374.6 EDK41201.2 - 0.17 11.8 2.0 12 6.0 0.0 4.2 4 1 0 5 5 5 0 Tetratricopeptide repeat FRB_dom PF08771.11 EDK41201.2 - 0.2 12.1 3.7 2.2 8.8 0.3 2.7 3 0 0 3 3 3 0 FKBP12-rapamycin binding domain TPR_11 PF13414.6 EDK41201.2 - 1.4 8.6 13.5 11 5.7 0.2 4.9 4 1 1 5 5 5 0 TPR repeat TPR_17 PF13431.6 EDK41201.2 - 1.6 9.3 5.7 11 6.6 0.2 4.0 4 1 1 5 5 4 0 Tetratricopeptide repeat MFS_1 PF07690.16 EDK41202.2 - 2.6e-22 79.3 6.2 2.6e-22 79.3 6.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2632 PF10943.8 EDK41202.2 - 0.026 14.1 0.6 0.026 14.1 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2632) MFS_1 PF07690.16 EDK41203.2 - 9.9e-17 60.9 49.9 6.6e-09 35.2 18.1 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 EDK41203.2 - 0.15 12.3 0.1 0.15 12.3 0.1 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF2530) CPSase_L_D2 PF02786.17 EDK41204.2 - 7.2e-23 81.2 0.0 1e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 EDK41204.2 - 4.7e-09 36.1 0.0 8.3e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDK41204.2 - 1.2e-08 34.8 0.1 2.2e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EDK41204.2 - 0.0013 18.5 0.0 0.0058 16.4 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Epimerase PF01370.21 EDK41204.2 - 0.0067 15.9 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GARS_A PF01071.19 EDK41204.2 - 0.01 15.7 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TrkA_N PF02254.18 EDK41204.2 - 0.021 15.1 0.0 0.07 13.4 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain ATP-grasp_5 PF13549.6 EDK41204.2 - 0.056 12.9 0.0 0.096 12.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 EDK41204.2 - 0.065 12.8 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 RimK-like ATP-grasp domain GDP_Man_Dehyd PF16363.5 EDK41204.2 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase CPSase_L_D2 PF02786.17 EDK41205.2 - 4.2e-85 284.5 0.0 1e-84 283.3 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EDK41205.2 - 1.9e-16 60.5 0.1 8.9e-16 58.3 0.0 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EDK41205.2 - 2.8e-09 36.8 0.0 5.5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDK41205.2 - 1.2e-07 31.5 0.0 2.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EDK41205.2 - 1.6e-05 24.6 0.0 4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 EDK41205.2 - 0.019 14.4 0.0 0.045 13.2 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain PIG-P PF08510.12 EDK41206.2 - 1.7e-35 121.6 9.1 2e-35 121.4 9.1 1.0 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 EDK41206.2 - 0.44 10.9 6.4 0.75 10.1 6.4 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) YrhC PF14143.6 EDK41206.2 - 0.77 9.9 3.1 3.7 7.7 0.2 2.2 2 0 0 2 2 2 0 YrhC-like protein HEAT_EZ PF13513.6 EDK41207.2 - 3.4e-30 104.1 1.1 8.5e-11 42.1 0.0 8.0 7 1 1 8 8 8 5 HEAT-like repeat HEAT PF02985.22 EDK41207.2 - 3.8e-25 85.8 20.8 0.00038 20.5 0.0 11.4 12 0 0 12 12 11 5 HEAT repeat HEAT_2 PF13646.6 EDK41207.2 - 2.9e-24 85.3 0.3 1.5e-06 28.5 0.0 8.9 6 2 3 9 9 9 5 HEAT repeats Cnd1 PF12717.7 EDK41207.2 - 1.2e-13 51.4 5.5 1.5e-07 31.6 0.3 4.9 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDK41207.2 - 9.1e-11 42.2 1.4 0.044 14.4 0.0 5.7 3 2 2 6 6 6 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EDK41207.2 - 6.5e-09 34.9 2.0 4.9e-07 28.7 0.2 3.5 3 1 0 3 3 3 1 Adaptin N terminal region IBN_N PF03810.19 EDK41207.2 - 5.5e-07 29.4 4.8 4.2e-05 23.4 0.1 4.3 3 1 1 4 4 4 1 Importin-beta N-terminal domain Arm PF00514.23 EDK41207.2 - 1.2e-06 28.3 13.2 0.24 11.5 0.1 7.8 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat Tti2 PF10521.9 EDK41207.2 - 0.00098 18.7 1.0 0.055 13.0 0.0 3.7 3 2 1 5 5 5 1 Tti2 family UNC45-central PF11701.8 EDK41207.2 - 0.0037 17.2 5.3 0.0063 16.5 0.5 3.5 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central V-ATPase_H_C PF11698.8 EDK41207.2 - 0.01 15.9 0.0 0.63 10.2 0.1 3.0 2 1 0 2 2 2 0 V-ATPase subunit H HEAT_PBS PF03130.16 EDK41207.2 - 0.028 15.1 0.2 2.5e+02 2.8 0.0 5.4 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Xpo1 PF08389.12 EDK41207.2 - 0.031 14.4 8.4 0.067 13.2 0.6 5.0 5 2 1 6 6 6 0 Exportin 1-like protein Dopey_N PF04118.14 EDK41207.2 - 0.037 13.1 0.1 0.14 11.3 0.0 2.1 2 0 0 2 2 2 0 Dopey, N-terminal RTP1_C1 PF10363.9 EDK41207.2 - 0.05 13.8 1.1 3.5 7.9 0.1 4.2 4 3 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF1981 PF09324.10 EDK41207.2 - 0.088 12.7 5.0 2.5 8.0 0.1 4.1 3 2 1 4 4 4 0 Domain of unknown function (DUF1981) DUF4366 PF14283.6 EDK41207.2 - 0.27 11.3 4.9 0.57 10.2 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) PBP1_TM PF14812.6 EDK41207.2 - 0.84 10.0 12.1 1.8 9.0 12.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CAF1A PF12253.8 EDK41207.2 - 1.5 9.0 8.8 3.5 7.9 8.8 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A SH3_1 PF00018.28 EDK41208.2 - 2.6e-07 30.2 2.1 4.7e-07 29.3 0.0 2.4 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 EDK41208.2 - 0.00075 19.3 1.3 0.064 13.1 0.1 3.3 3 0 0 3 3 3 1 Variant SH3 domain FTR1 PF03239.14 EDK41209.2 - 1.3e-75 254.4 8.7 1.5e-75 254.2 8.7 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Pex2_Pex12 PF04757.14 EDK41209.2 - 0.028 14.0 0.0 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region E1_DerP2_DerF2 PF02221.15 EDK41210.2 - 3.9e-27 95.3 0.1 4.7e-27 95.0 0.1 1.1 1 0 0 1 1 1 1 ML domain Alph_Pro_TM PF09608.10 EDK41210.2 - 0.083 12.7 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Sulfate_transp PF00916.20 EDK41211.2 - 5.2e-68 229.5 15.6 9.5e-68 228.7 15.6 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDK41211.2 - 4.7e-14 52.0 0.0 3.1e-12 46.2 0.0 2.4 2 0 0 2 2 2 1 STAS domain cNMP_binding PF00027.29 EDK41211.2 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain PCDO_beta_N PF12391.8 EDK41211.2 - 0.076 12.6 0.5 0.13 11.9 0.5 1.4 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal Pkinase PF00069.25 EDK41213.2 - 6.9e-44 150.2 0.0 1.4e-40 139.4 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41213.2 - 3e-15 56.2 0.0 3.5e-12 46.1 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EDK41213.2 - 0.0045 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK41213.2 - 0.15 11.4 0.0 4.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Bot1p PF12298.8 EDK41214.1 - 2e-23 83.4 0.0 3e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein RPA_C PF08784.11 EDK41214.1 - 0.064 13.9 0.0 0.097 13.3 0.0 1.3 1 0 0 1 1 1 0 Replication protein A C terminal DUF433 PF04255.14 EDK41214.1 - 0.088 12.7 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Sigma70_r3 PF04539.16 EDK41214.1 - 0.13 12.4 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-70 region 3 Bot1p PF12298.8 EDK41215.2 - 3.8e-23 82.5 0.1 5.1e-23 82.1 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein EMP24_GP25L PF01105.24 EDK41216.2 - 6.3e-44 150.1 0.3 8.4e-44 149.7 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2569 PF10754.9 EDK41216.2 - 0.035 14.6 1.0 0.048 14.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) SLATT_1 PF18181.1 EDK41216.2 - 0.33 10.9 2.3 1.9 8.4 0.1 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DASH_Duo1 PF08651.10 EDK41216.2 - 0.45 10.3 2.0 0.39 10.5 0.4 1.7 2 0 0 2 2 2 0 DASH complex subunit Duo1 RNA_pol_A_bac PF01000.26 EDK41218.2 - 1e-30 106.4 0.0 1.8e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDK41218.2 - 2.9e-21 74.6 0.0 4.2e-21 74.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Prot_ATP_OB_N PF17758.1 EDK41218.2 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF1746 PF08508.10 EDK41219.2 - 3.1e-22 79.1 3.0 4.4e-22 78.6 3.0 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) SQHop_cyclase_C PF13243.6 EDK41220.2 - 5.9e-44 150.5 0.0 1.6e-43 149.0 0.0 1.7 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EDK41220.2 - 1.9e-38 132.3 0.0 9.3e-31 107.0 0.0 3.3 2 1 1 3 3 3 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EDK41220.2 - 7.3e-28 96.0 2.6 1.8e-10 40.4 0.2 4.2 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EDK41220.2 - 1.3e-05 24.7 0.9 0.27 10.5 0.3 3.7 3 1 1 4 4 4 2 Pectic acid lyase TED_complement PF07678.14 EDK41220.2 - 0.0011 18.1 0.3 0.011 14.8 0.1 2.4 2 1 1 3 3 3 1 A-macroglobulin TED domain Nrap_D2 PF17403.2 EDK41221.2 - 2.8e-51 173.3 0.3 2.8e-48 163.5 0.0 2.4 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 EDK41221.2 - 4.8e-50 169.9 0.0 1e-49 168.8 0.0 1.6 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EDK41221.2 - 7.5e-50 168.9 0.0 1.8e-49 167.6 0.0 1.7 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EDK41221.2 - 2.2e-43 147.9 1.1 5.9e-43 146.5 1.1 1.8 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EDK41221.2 - 7.5e-42 143.1 0.0 1.7e-41 141.9 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EDK41221.2 - 1.2e-23 83.8 0.1 2.9e-23 82.6 0.1 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 GCIP PF13324.6 EDK41221.2 - 0.083 12.5 1.5 0.14 11.7 1.5 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RNA_pol_Rbc25 PF08292.12 EDK41221.2 - 0.51 10.6 1.8 0.7 10.1 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Amidohydro_1 PF01979.20 EDK41223.2 - 7.1e-35 120.9 0.0 1.7e-16 60.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 EDK41223.2 - 3.5e-12 46.6 0.0 2.6e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Rrp44_CSD1 PF17216.3 EDK41223.2 - 0.049 13.3 1.1 6.6 6.4 0.5 2.3 1 1 0 2 2 2 0 Rrp44-like cold shock domain ADH_zinc_N PF00107.26 EDK41224.2 - 1.7e-16 60.4 0.0 2.8e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDK41224.2 - 3.6e-07 31.3 0.0 6.1e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDK41224.2 - 0.0034 17.3 0.0 0.0083 16.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Trp_ring PF18669.1 EDK41224.2 - 0.014 15.6 0.1 0.043 14.0 0.1 1.8 1 0 0 1 1 1 0 Trimeric autotransporter adhesin Trp ring domain Mpv17_PMP22 PF04117.12 EDK41225.2 - 7.1e-06 26.2 0.3 1.7e-05 24.9 0.3 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF5408 PF17402.2 EDK41225.2 - 0.0015 18.4 0.2 0.0067 16.3 0.1 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5408) Sugar_tr PF00083.24 EDK41226.2 - 3.1e-91 306.5 27.9 3.8e-91 306.2 27.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41226.2 - 1.2e-15 57.3 32.5 1.2e-15 57.3 32.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ArfGap PF01412.18 EDK41228.2 - 5.3e-33 113.6 0.9 1.4e-32 112.2 0.9 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Hamartin PF04388.12 EDK41228.2 - 0.44 9.1 12.7 0.59 8.7 12.7 1.1 1 0 0 1 1 1 0 Hamartin protein Tim44 PF04280.15 EDK41229.1 - 9.9e-38 129.5 0.5 2.3e-37 128.3 0.1 1.8 2 0 0 2 2 2 1 Tim44-like domain Senescence PF06911.12 EDK41229.1 - 0.0082 16.5 0.7 0.013 15.8 0.7 1.5 1 0 0 1 1 1 1 Senescence-associated protein MapZ_EC1 PF18041.1 EDK41229.1 - 0.091 13.0 3.0 0.19 12.0 2.0 2.0 2 0 0 2 2 2 0 MapZ extracellular domain 1 FAD_binding_3 PF01494.19 EDK41230.2 - 1.6e-20 73.7 0.0 3.7e-20 72.5 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EDK41230.2 - 1.1e-05 25.9 0.1 0.0008 19.9 0.1 3.1 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK41230.2 - 2.2e-05 24.6 0.0 4.9e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDK41230.2 - 0.00023 20.8 0.0 0.0079 15.8 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDK41230.2 - 0.00044 19.6 0.0 0.016 14.4 0.0 2.0 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EDK41230.2 - 0.0013 17.9 0.0 0.038 13.1 0.0 2.4 3 0 0 3 3 3 1 Squalene epoxidase 3HCDH_N PF02737.18 EDK41230.2 - 0.0014 18.5 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EDK41230.2 - 0.0015 17.7 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EDK41230.2 - 0.008 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EDK41230.2 - 0.026 13.3 0.1 0.17 10.5 0.1 2.0 1 1 0 1 1 1 0 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 EDK41230.2 - 0.028 14.0 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_2 PF00890.24 EDK41230.2 - 0.044 12.9 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain RabGAP-TBC PF00566.18 EDK41231.2 - 3e-05 23.8 5.2 3e-05 23.8 5.2 3.0 3 0 0 3 3 3 1 Rab-GTPase-TBC domain HalX PF08663.10 EDK41231.2 - 0.14 12.5 4.8 3.4 8.1 0.4 2.9 2 1 0 2 2 2 0 HalX domain TPR_MLP1_2 PF07926.12 EDK41231.2 - 0.17 12.0 20.6 0.079 13.0 17.0 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ABC_tran_CTD PF16326.5 EDK41231.2 - 0.2 11.9 14.5 1.1 9.6 5.9 2.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF3450 PF11932.8 EDK41231.2 - 0.51 9.6 13.6 0.83 8.9 13.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Mer2 PF09074.10 EDK41231.2 - 0.87 9.4 24.2 1 9.2 20.8 2.4 2 1 0 2 2 2 0 Mer2 UPF0449 PF15136.6 EDK41231.2 - 1.3 9.5 14.3 0.85 10.1 8.1 2.6 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Cnn_1N PF07989.11 EDK41231.2 - 1.6 9.0 23.3 8.4 6.6 9.2 2.8 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 EDK41231.2 - 1.9 7.5 18.2 3.9 6.5 18.2 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4763 PF15960.5 EDK41231.2 - 4.6 6.5 17.8 0.38 10.0 10.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Mod_r PF07200.13 EDK41231.2 - 5.4 7.1 24.2 5.4 7.1 13.6 2.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Tropomyosin_1 PF12718.7 EDK41231.2 - 6.6 6.9 23.4 22 5.2 23.4 1.9 1 1 0 1 1 1 0 Tropomyosin like Sas10_Utp3 PF04000.15 EDK41231.2 - 7.3 7.3 13.5 9.3 7.0 4.8 3.5 3 0 0 3 3 3 0 Sas10/Utp3/C1D family Peptidase_C48 PF02902.19 EDK41232.2 - 1.2e-28 100.4 2.0 1.2e-28 100.4 2.0 2.2 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain 4HBT PF03061.22 EDK41233.1 - 4e-06 27.1 0.0 5.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF3918 PF13056.6 EDK41233.1 - 0.053 13.1 0.0 0.091 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) HSP9_HSP12 PF04119.12 EDK41234.1 - 2.5e-22 79.0 3.3 2.7e-22 78.9 3.3 1.0 1 0 0 1 1 1 1 Heat shock protein 9/12 Thymidylat_synt PF00303.19 EDK41235.1 - 9.5e-115 382.3 0.0 1.1e-114 382.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Ku_PK_bind PF08785.11 EDK41235.1 - 0.11 12.6 0.0 0.47 10.6 0.0 1.9 2 0 0 2 2 2 0 Ku C terminal domain like DASH_Dad2 PF08654.10 EDK41236.1 - 1.5e-27 95.9 3.1 3.5e-27 94.7 3.1 1.5 1 1 0 1 1 1 1 DASH complex subunit Dad2 NPV_P10 PF05531.12 EDK41236.1 - 0.0011 19.4 1.4 0.0015 19.0 1.4 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 EDK41236.1 - 0.0013 18.9 2.0 0.0017 18.6 2.0 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DASH_Duo1 PF08651.10 EDK41236.1 - 0.0044 16.8 1.7 0.0071 16.1 1.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 BRX_N PF13713.6 EDK41236.1 - 0.056 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain FliD_N PF02465.18 EDK41236.1 - 0.068 13.9 1.1 0.086 13.5 1.1 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Shugoshin_N PF07558.11 EDK41237.2 - 9.7e-13 47.8 6.0 9.7e-13 47.8 6.0 2.4 3 0 0 3 3 3 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EDK41237.2 - 1.8e-07 30.8 9.9 5.7e-07 29.2 9.9 1.9 1 0 0 1 1 1 1 Shugoshin C terminus Nucleoporin_N PF08801.11 EDK41238.2 - 1.1e-73 248.5 0.5 1.9e-73 247.7 0.5 1.4 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDK41238.2 - 1.1e-47 163.2 22.8 2.9e-47 161.7 22.8 1.6 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nit_Regul_Hom PF10126.9 EDK41238.2 - 0.076 13.0 0.9 1.3 9.1 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII PCI PF01399.27 EDK41238.2 - 0.27 11.8 4.0 8.8 6.9 0.2 3.7 4 0 0 4 4 4 0 PCI domain Brix PF04427.18 EDK41239.2 - 1.6e-41 142.5 1.9 2.2e-41 142.1 1.9 1.2 1 0 0 1 1 1 1 Brix domain FAD_binding_8 PF08022.12 EDK41240.2 - 4.6e-22 78.2 0.0 1e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDK41240.2 - 1e-19 71.2 0.0 1.6e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDK41240.2 - 1.5e-18 67.1 17.8 2.3e-18 66.5 14.5 2.9 3 0 0 3 3 3 1 Ferric reductase like transmembrane component MaoC_dehydratas PF01575.19 EDK41241.2 - 4.3e-09 36.0 0.0 2.7e-08 33.4 0.0 2.2 3 0 0 3 3 3 1 MaoC like domain Sugar_tr PF00083.24 EDK41242.2 - 8.9e-93 311.6 20.9 1.1e-92 311.3 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41242.2 - 3.8e-28 98.4 26.5 6.8e-19 68.0 6.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EDK41242.2 - 0.00016 20.3 2.9 0.00031 19.3 2.9 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDK41242.2 - 0.00024 19.6 2.1 0.00024 19.6 2.1 2.6 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF3100 PF11299.8 EDK41242.2 - 0.93 8.9 5.9 2.4 7.5 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3100) ParBc PF02195.18 EDK41243.1 - 3.6e-15 56.0 0.0 4.2e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain FAD_binding_8 PF08022.12 EDK41244.2 - 5.4e-24 84.4 0.0 9.9e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EDK41244.2 - 3.2e-22 79.3 0.0 4.8e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDK41244.2 - 7.7e-20 71.3 13.2 1.9e-19 70.0 10.8 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component Phage-tail_3 PF13550.6 EDK41244.2 - 0.0091 15.9 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 1 Putative phage tail protein DUF3394 PF11874.8 EDK41244.2 - 0.14 11.8 0.2 0.29 10.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) FTR1 PF03239.14 EDK41245.2 - 4.5e-82 275.7 0.7 3.5e-80 269.4 0.7 2.0 1 1 0 1 1 1 1 Iron permease FTR1 family Sbt_1 PF05982.12 EDK41245.2 - 0.034 13.4 8.7 0.045 13.0 0.2 2.8 3 0 0 3 3 3 0 Na+-dependent bicarbonate transporter superfamily Acetate_kinase PF00871.17 EDK41245.2 - 0.09 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family HlyIII PF03006.20 EDK41245.2 - 0.18 11.5 7.1 0.98 9.1 0.4 2.8 2 1 0 2 2 2 0 Haemolysin-III related DUF2207 PF09972.9 EDK41245.2 - 0.19 10.5 2.2 1 8.0 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EDK41245.2 - 0.56 10.3 7.2 7 6.7 0.3 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Pkinase PF00069.25 EDK41246.2 - 3.2e-62 210.3 0.0 4e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41246.2 - 1.5e-30 106.3 0.0 2.5e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDK41246.2 - 0.00053 19.0 0.4 0.00094 18.2 0.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDK41246.2 - 0.0083 15.5 0.5 0.028 13.7 0.1 1.9 2 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EDK41246.2 - 0.013 14.5 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Sugar_tr PF00083.24 EDK41247.1 - 2.4e-110 369.5 34.2 2.8e-110 369.3 34.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41247.1 - 1.6e-27 96.4 41.9 1.4e-26 93.3 30.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cytochrom_C1 PF02167.15 EDK41248.1 - 1e-94 316.4 0.0 1.2e-94 316.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EDK41248.1 - 0.0044 17.3 0.1 0.01 16.2 0.1 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EDK41248.1 - 0.03 15.5 0.5 0.075 14.2 0.4 1.9 2 1 0 2 2 2 0 Cytochrome c DUF2340 PF10209.9 EDK41249.1 - 7.8e-50 168.3 0.8 9.1e-50 168.1 0.8 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF4252 PF14060.6 EDK41249.1 - 0.1 12.5 0.2 0.13 12.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) CH PF00307.31 EDK41250.2 - 6.8e-26 90.6 5.1 1.9e-19 69.9 0.2 3.4 2 1 0 2 2 2 2 Calponin homology (CH) domain DUF2203 PF09969.9 EDK41250.2 - 0.003 18.3 0.2 0.36 11.6 0.2 3.0 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2203) CAMSAP_CH PF11971.8 EDK41250.2 - 0.008 16.0 0.4 0.16 11.9 0.0 3.0 3 0 0 3 3 3 1 CAMSAP CH domain MetOD2 PF18548.1 EDK41250.2 - 0.027 14.6 0.2 1.4 9.1 0.2 2.8 2 0 0 2 2 2 0 Metanogen output domain 2 NHR2 PF08788.11 EDK41250.2 - 0.062 13.1 0.3 0.49 10.2 0.1 2.5 2 0 0 2 2 2 0 NHR2 domain like CLZ PF16526.5 EDK41250.2 - 0.18 12.2 1.9 1.5 9.2 0.4 2.9 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pkinase PF00069.25 EDK41251.2 - 2e-59 201.2 0.0 2.3e-59 200.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41251.2 - 1.4e-17 63.8 0.0 1.9e-16 60.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDK41251.2 - 3.5e-06 27.1 0.0 1e-05 25.6 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK41251.2 - 0.0049 16.2 0.0 0.012 15.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EDK41251.2 - 0.041 13.5 0.1 0.079 12.5 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EDK41251.2 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Sld7_C PF18596.1 EDK41252.2 - 6e-23 80.8 0.0 1.3e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Sld7 C-terminal domain Sld7_N PF18636.1 EDK41252.2 - 7.8e-09 35.9 0.2 4e-08 33.6 0.2 2.2 1 1 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain P30 PF07390.11 EDK41252.2 - 0.065 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 Mycoplasma P30 protein Ribosomal_L27A PF00828.19 EDK41253.1 - 9.1e-29 100.7 0.4 1.9e-28 99.7 0.1 1.7 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF3128 PF11326.8 EDK41254.2 - 1.9e-26 92.3 1.4 2.4e-26 91.9 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) PTS_IIA PF02255.16 EDK41254.2 - 0.097 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Ras PF00071.22 EDK41255.1 - 4.1e-22 78.5 0.0 4.8e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Insulin_TMD PF17870.1 EDK41256.2 - 0.002 18.2 0.3 0.0035 17.4 0.3 1.3 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment DUF1391 PF07151.12 EDK41257.2 - 0.082 12.7 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) THOC2_N PF16134.5 EDK41258.2 - 6.3e-172 573.5 7.1 6.3e-172 573.5 7.1 3.4 2 1 1 3 3 3 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EDK41258.2 - 6.5e-74 248.8 2.3 6.5e-74 248.8 2.3 3.3 3 0 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EDK41258.2 - 1.9e-25 88.7 0.6 6.4e-25 87.0 0.1 2.3 2 0 0 2 2 2 1 Transcription- and export-related complex subunit zf-C2H2 PF00096.26 EDK41259.2 - 4.9e-26 89.7 68.9 5.6e-05 23.4 0.2 9.3 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDK41259.2 - 2.8e-18 65.0 69.9 0.029 15.2 1.3 9.3 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDK41259.2 - 7.9e-12 45.0 68.1 3.8e-06 27.1 0.7 10.0 9 1 0 9 9 9 5 Zinc-finger double domain zf-met PF12874.7 EDK41259.2 - 1.8e-05 25.0 26.9 0.37 11.3 0.6 7.5 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDK41259.2 - 1.2 9.5 36.6 5.3 7.5 0.1 8.5 8 1 1 9 9 9 0 Zinc-finger double-stranded RNA-binding ADD_ATRX PF17981.1 EDK41259.2 - 1.9 8.4 17.2 5.9 6.8 0.5 4.7 2 1 2 4 4 4 0 Cysteine Rich ADD domain HypA PF01155.19 EDK41259.2 - 7.2 6.7 13.6 4.7 7.3 1.9 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA hDGE_amylase PF14701.6 EDK41260.2 - 6e-173 576.0 0.0 7.9e-173 575.6 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain hGDE_central PF14702.6 EDK41260.2 - 3.5e-52 177.6 0.0 6.8e-52 176.7 0.0 1.5 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EDK41260.2 - 3.2e-27 94.5 0.7 6.8e-27 93.4 0.7 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 EDK41260.2 - 6.1e-05 22.7 0.2 0.00013 21.7 0.2 1.5 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF4038 PF13204.6 EDK41260.2 - 0.12 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) SRP72 PF08492.12 EDK41261.2 - 2.1e-06 28.1 1.5 2.1e-06 28.1 1.5 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_MalT PF17874.1 EDK41261.2 - 0.0093 15.4 0.7 0.88 8.9 0.2 3.3 3 1 1 4 4 4 1 MalT-like TPR region TPR_6 PF13174.6 EDK41261.2 - 0.077 13.7 0.2 14 6.6 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDK41261.2 - 0.093 13.3 13.2 3.3 8.3 1.9 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Aldedh PF00171.22 EDK41262.2 - 3.6e-78 263.1 0.5 4.3e-78 262.9 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pro_Al_protease PF02983.14 EDK41262.2 - 0.21 11.6 0.5 3.3 7.8 0.1 2.6 2 0 0 2 2 2 0 Alpha-lytic protease prodomain Hap4_Hap_bind PF10297.9 EDK41264.2 - 3.2e-07 30.2 10.7 3.2e-07 30.2 10.7 1.8 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DUF4515 PF14988.6 EDK41264.2 - 0.03 14.2 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) FGGY_N PF00370.21 EDK41265.2 - 1.2e-16 61.0 0.0 1e-09 38.4 0.0 3.0 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EDK41265.2 - 2.7e-12 46.8 0.0 3.5e-11 43.2 0.0 2.5 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4795 PF16043.5 EDK41266.2 - 0.026 14.1 0.5 0.072 12.7 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) AlaDh_PNT_N PF05222.15 EDK41267.1 - 8.6e-28 97.3 0.0 1.5e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EDK41267.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain WD40 PF00400.32 EDK41268.1 - 4e-22 78.1 5.2 2.6e-06 28.1 0.1 5.6 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK41268.1 - 1.6e-09 38.0 1.7 0.0042 17.4 0.1 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK41268.1 - 9.4e-08 31.1 0.3 0.0047 15.6 0.0 2.7 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDK41268.1 - 6.9e-05 21.8 4.1 1.4 7.6 0.1 4.7 1 1 4 5 5 5 2 Nup133 N terminal like BBS2_Mid PF14783.6 EDK41268.1 - 0.003 17.6 0.5 5.1 7.2 0.0 4.3 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Hira PF07569.11 EDK41268.1 - 0.079 12.7 0.1 0.63 9.7 0.0 2.5 3 0 0 3 3 3 0 TUP1-like enhancer of split CobW_C PF07683.14 EDK41268.1 - 0.096 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain LigT_PEase PF02834.16 EDK41269.2 - 7.9e-08 32.4 0.2 0.0051 17.0 0.0 2.3 2 0 0 2 2 2 2 LigT like Phosphoesterase 2H-phosphodiest PF08975.10 EDK41269.2 - 0.0017 18.3 0.7 0.0037 17.2 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1868) 2_5_RNA_ligase2 PF13563.6 EDK41269.2 - 0.0027 17.6 0.6 0.023 14.6 0.8 1.9 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily Helicase_C_3 PF13625.6 EDK41269.2 - 0.092 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Helicase conserved C-terminal domain TPR_2 PF07719.17 EDK41270.2 - 1.4e-34 115.3 23.3 1.1e-05 25.1 0.2 11.6 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_1 PF00515.28 EDK41270.2 - 2.6e-34 115.6 10.9 2.6e-06 27.0 0.3 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK41270.2 - 4.8e-24 84.4 28.5 9.5e-24 83.4 0.5 5.8 4 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EDK41270.2 - 4.5e-23 79.5 10.5 1.7e-05 24.6 0.2 9.4 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDK41270.2 - 5.9e-19 68.1 23.1 7.8e-10 38.9 0.7 9.0 4 3 6 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EDK41270.2 - 1.2e-15 56.9 5.8 2.4 9.2 0.0 9.4 6 2 4 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EDK41270.2 - 7.5e-15 55.3 7.0 0.013 16.1 0.0 6.2 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDK41270.2 - 1.5e-12 46.6 18.5 0.0088 16.0 0.0 8.4 9 1 1 10 10 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDK41270.2 - 3.8e-12 46.5 15.8 0.047 14.2 0.1 7.8 4 2 6 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EDK41270.2 - 4.5e-12 45.4 2.5 0.00052 19.6 0.0 7.3 5 2 3 8 8 8 3 TPR repeat TPR_9 PF13371.6 EDK41270.2 - 2.6e-11 43.5 5.5 6.3e-06 26.3 0.0 5.6 4 2 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDK41270.2 - 3.2e-11 42.8 14.1 1.3 9.6 0.0 9.3 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDK41270.2 - 3.7e-10 39.3 15.3 0.0077 16.1 0.6 8.0 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDK41270.2 - 1.3e-07 31.7 11.6 1.1 10.0 0.1 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK41270.2 - 8.4e-07 28.7 5.3 0.00049 19.6 0.5 3.9 3 1 0 4 4 4 1 MalT-like TPR region Cohesin_load PF10345.9 EDK41270.2 - 0.0047 15.4 0.7 0.96 7.8 0.4 2.8 3 0 0 3 3 3 2 Cohesin loading factor DUF2127 PF09900.9 EDK41270.2 - 0.48 10.7 2.7 0.81 9.9 0.1 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2127) TPR_21 PF09976.9 EDK41270.2 - 0.92 9.2 4.6 2.9 7.6 0.0 3.5 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain ANAPC4_WD40 PF12894.7 EDK41271.2 - 0.00074 19.8 0.1 0.1 12.9 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK41271.2 - 0.031 15.2 7.8 0.11 13.4 0.0 4.4 6 0 0 6 6 6 0 WD domain, G-beta repeat BRAP2 PF07576.12 EDK41272.2 - 8.6e-05 22.7 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 DUF5424 PF17462.2 EDK41272.2 - 0.078 12.9 0.2 0.19 11.6 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5424) PUF PF00806.19 EDK41273.2 - 2.2e-59 193.9 15.0 6.5e-08 31.9 0.0 8.7 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat THP2 PF09432.10 EDK41273.2 - 0.04 14.0 0.6 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 Tho complex subunit THP2 DUF4458 PF14660.6 EDK41273.2 - 0.077 13.2 0.4 0.17 12.1 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4458) SIS PF01380.22 EDK41274.2 - 9e-13 48.2 0.0 1.9e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EDK41274.2 - 0.0048 16.9 0.0 0.081 12.9 0.0 2.4 1 1 1 2 2 2 1 SIS domain DUF3384 PF11864.8 EDK41275.2 - 7.4e-90 302.1 8.6 7.4e-90 302.1 8.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EDK41275.2 - 1.2e-47 161.9 4.5 2.3e-47 160.9 1.8 2.5 3 0 0 3 3 3 1 Rap/ran-GAP Tuberin PF03542.16 EDK41275.2 - 1.1e-24 87.2 8.7 8e-22 77.8 7.4 3.3 2 1 0 2 2 2 2 Tuberin AA_permease PF00324.21 EDK41276.2 - 1.1e-141 472.7 40.8 1.3e-141 472.5 40.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK41276.2 - 1.5e-42 145.9 41.6 1.9e-42 145.6 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EDK41276.2 - 0.2 10.4 1.1 0.36 9.6 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF3671 PF12420.8 EDK41276.2 - 2.8 8.1 6.3 19 5.4 0.6 3.4 2 1 1 3 3 3 0 Protein of unknown function Vps62 PF06101.11 EDK41277.1 - 6e-11 41.4 0.8 1.1e-10 40.5 0.8 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 NAD_binding_1 PF00175.21 EDK41278.1 - 8.3e-33 113.3 0.0 1.9e-32 112.2 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDK41278.1 - 1.1e-31 109.1 0.0 1.7e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDK41278.1 - 0.00054 20.1 0.0 0.006 16.7 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Ofd1_CTDD PF10637.9 EDK41279.2 - 1.5e-93 312.9 0.1 6.7e-92 307.4 0.1 2.3 2 0 0 2 2 2 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EDK41279.2 - 6.4e-28 97.3 0.0 3.5e-27 94.9 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EDK41279.2 - 3.6e-14 53.4 0.0 9.5e-14 52.1 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EDK41279.2 - 0.11 13.0 0.0 0.82 10.2 0.0 2.3 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily AA_kinase PF00696.28 EDK41280.2 - 3.5e-44 151.2 0.1 7.4e-44 150.2 0.0 1.6 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 EDK41280.2 - 1.3e-07 31.2 0.9 0.003 17.3 0.4 2.7 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 EDK41280.2 - 2.5e-06 27.2 2.7 0.00012 21.8 0.6 2.4 2 0 0 2 2 2 2 ACT domain CbiG_mid PF11761.8 EDK41280.2 - 0.012 15.7 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 Cobalamin biosynthesis central region BAR_2 PF10455.9 EDK41281.2 - 2.1e-65 220.7 7.7 3.1e-65 220.2 7.7 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDK41281.2 - 4.1e-18 65.9 5.2 3e-17 63.1 5.2 2.1 1 1 0 1 1 1 1 BAR domain Arfaptin PF06456.13 EDK41281.2 - 0.0013 18.3 2.0 0.046 13.3 0.1 2.5 1 1 1 2 2 2 1 Arfaptin-like domain PAS_12 PF18095.1 EDK41281.2 - 0.029 14.0 0.1 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 UPF0242 C-terminal PAS-like domain UPF0236 PF06782.11 EDK41281.2 - 0.029 13.0 0.6 0.047 12.3 0.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) Csm2_III-A PF03750.13 EDK41281.2 - 0.052 14.4 6.1 0.078 13.8 2.9 2.5 2 1 0 2 2 2 0 Csm2 Type III-A Frataxin_Cyay PF01491.16 EDK41281.2 - 0.11 12.6 2.7 1 9.4 0.1 3.1 3 1 1 4 4 4 0 Frataxin-like domain P22_AR_C PF10548.9 EDK41281.2 - 0.12 12.6 0.0 0.95 9.7 0.0 2.4 2 0 0 2 2 2 0 P22AR C-terminal domain Fib_alpha PF08702.10 EDK41281.2 - 2.2 8.5 11.1 1.3 9.2 0.6 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family 7TMR-HDED PF07697.11 EDK41281.2 - 8.4 6.4 11.6 2.4e+02 1.7 11.6 2.3 1 1 0 1 1 1 0 7TM-HD extracellular Aminotran_1_2 PF00155.21 EDK41282.2 - 1.3e-23 83.8 0.0 1.9e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDK41282.2 - 0.0016 17.3 0.0 0.017 14.0 0.0 2.2 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Tubulin PF00091.25 EDK41283.2 - 1e-45 156.4 0.1 1.8e-45 155.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDK41283.2 - 3.5e-10 40.1 0.1 5.8e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDK41283.2 - 0.0067 16.1 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain DUF4817 PF16087.5 EDK41283.2 - 0.18 11.6 0.1 0.41 10.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) adh_short_C2 PF13561.6 EDK41284.2 - 8.6e-30 104.0 0.0 1.1e-29 103.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41284.2 - 2.5e-29 102.1 0.0 3.1e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41284.2 - 7.5e-10 39.0 0.0 1.2e-09 38.3 0.0 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK41284.2 - 0.00019 21.0 0.0 0.00038 20.0 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDK41284.2 - 0.00072 19.5 0.0 0.0013 18.6 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding PdxJ PF03740.13 EDK41284.2 - 0.0033 16.6 0.0 0.007 15.5 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal phosphate biosynthesis protein PdxJ Astro_capsid_N PF03115.14 EDK41284.2 - 0.016 13.9 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor F420_oxidored PF03807.17 EDK41284.2 - 0.07 13.7 0.0 0.25 11.9 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 EDK41285.2 - 7.5e-30 103.8 0.0 9.4e-30 103.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDK41285.2 - 9.9e-28 97.3 0.0 1.2e-27 97.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK41285.2 - 1.6e-11 44.5 0.0 4.2e-11 43.1 0.0 1.5 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EDK41285.2 - 4.3e-05 23.1 0.0 8e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDK41285.2 - 0.0015 18.4 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding STALD PF18185.1 EDK41285.2 - 0.0093 15.3 0.2 0.29 10.4 0.0 2.7 2 1 1 3 3 3 1 Sir2- and TIR-associating SLOG family DUF1776 PF08643.10 EDK41285.2 - 0.044 13.2 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF3919 PF13057.6 EDK41285.2 - 0.11 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) Fungal_trans PF04082.18 EDK41286.2 - 2.1e-22 79.4 0.1 3.9e-22 78.5 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK41286.2 - 1.3e-05 25.2 12.1 3.4e-05 23.9 12.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EDK41286.2 - 0.017 15.2 0.1 0.038 14.2 0.1 1.6 1 0 0 1 1 1 0 Gal4-like dimerisation domain PUFD PF16553.5 EDK41286.2 - 0.14 12.3 0.8 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 BCORL-PCGF1-binding domain adh_short_C2 PF13561.6 EDK41287.1 - 2.9e-58 197.2 0.1 3.7e-58 196.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41287.1 - 1.2e-44 152.1 0.2 1.6e-44 151.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41287.1 - 3.6e-14 53.1 0.3 6e-14 52.3 0.3 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK41287.1 - 0.00056 19.4 0.1 0.00078 19.0 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDK41287.1 - 0.0096 15.4 0.2 0.016 14.6 0.0 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase LDcluster4 PF18306.1 EDK41287.1 - 0.034 13.7 0.3 0.19 11.3 0.1 1.9 2 0 0 2 2 2 0 SLOG cluster4 family Spermine_synth PF01564.17 EDK41287.1 - 0.035 13.5 0.2 0.055 12.9 0.2 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Eno-Rase_NADH_b PF12242.8 EDK41287.1 - 0.042 13.6 0.1 0.094 12.5 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PRK PF00485.18 EDK41288.2 - 7.6e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EDK41288.2 - 3.4e-06 27.6 0.0 7.3e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EDK41288.2 - 1.9e-05 24.1 0.0 3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Zeta_toxin PF06414.12 EDK41288.2 - 4.1e-05 22.9 0.0 7.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.10 EDK41288.2 - 4.3e-05 23.1 0.0 7.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 6PF2K PF01591.18 EDK41288.2 - 7.8e-05 22.1 0.0 0.00015 21.2 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 EDK41288.2 - 9e-05 22.7 0.0 0.017 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EDK41288.2 - 0.0003 20.1 0.0 0.00044 19.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EDK41288.2 - 0.0018 18.7 0.0 0.0049 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 EDK41288.2 - 0.002 17.8 0.0 0.0031 17.2 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain APS_kinase PF01583.20 EDK41288.2 - 0.0047 16.8 0.0 0.0098 15.8 0.0 1.5 2 0 0 2 2 1 1 Adenylylsulphate kinase MeaB PF03308.16 EDK41288.2 - 0.0079 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EDK41288.2 - 0.0091 16.1 0.4 0.026 14.6 0.1 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.6 EDK41288.2 - 0.012 16.0 0.1 0.073 13.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDK41288.2 - 0.017 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 EDK41288.2 - 0.018 15.4 0.0 0.029 14.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK41288.2 - 0.022 14.8 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 EDK41288.2 - 0.026 14.3 0.2 0.042 13.6 0.2 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.18 EDK41288.2 - 0.031 14.0 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EDK41288.2 - 0.035 14.0 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 EDK41288.2 - 0.04 14.4 0.0 0.074 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RuvB_N PF05496.12 EDK41288.2 - 0.043 13.5 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDK41288.2 - 0.045 13.1 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ribosomal_S27 PF01599.19 EDK41288.2 - 0.058 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S27a AAA_30 PF13604.6 EDK41288.2 - 0.068 12.9 0.0 0.094 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 EDK41288.2 - 0.074 13.2 0.6 3.4 7.8 0.2 2.2 2 0 0 2 2 2 0 Cytidylate kinase-like family Ploopntkinase1 PF18748.1 EDK41288.2 - 0.079 12.5 0.1 0.82 9.1 0.0 2.1 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 CoaE PF01121.20 EDK41288.2 - 0.091 12.4 0.2 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase FeoB_N PF02421.18 EDK41288.2 - 0.1 12.1 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B dNK PF01712.19 EDK41288.2 - 0.11 12.3 0.1 1.8 8.4 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase NACHT PF05729.12 EDK41288.2 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EDK41288.2 - 0.15 12.3 0.0 0.26 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EDK41288.2 - 0.16 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ADH_N PF08240.12 EDK41289.1 - 6.9e-30 103.1 1.4 1.3e-29 102.3 0.8 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK41289.1 - 1.4e-18 67.2 0.1 2.4e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK41289.1 - 5.1e-07 29.4 0.1 1e-05 25.1 0.1 2.2 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDK41289.1 - 1.5e-05 26.1 0.0 3.4e-05 24.9 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EDK41289.1 - 0.00017 22.2 0.0 0.00038 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK41289.1 - 0.003 17.4 0.1 0.0058 16.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK41289.1 - 0.0097 16.5 0.0 0.022 15.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 EDK41289.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CMAS PF02353.20 EDK41289.1 - 0.065 12.5 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDK41289.1 - 0.086 13.6 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EDK41289.1 - 0.11 12.0 0.1 0.24 11.0 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase small domain adh_short_C2 PF13561.6 EDK41290.1 - 3.7e-61 206.7 0.1 4.3e-61 206.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41290.1 - 3.5e-44 150.6 0.2 4.5e-44 150.3 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41290.1 - 6e-13 49.1 0.6 8.2e-13 48.7 0.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK41290.1 - 0.019 14.4 0.4 0.035 13.6 0.4 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pyr_redox_2 PF07992.14 EDK41290.1 - 0.048 12.9 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NmrA PF05368.13 EDK41290.1 - 0.12 11.9 0.2 0.21 11.1 0.1 1.5 2 0 0 2 2 2 0 NmrA-like family Sugar_tr PF00083.24 EDK41291.2 - 2.7e-85 286.9 18.6 3.1e-85 286.7 18.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41291.2 - 4.3e-24 85.1 27.6 4.4e-22 78.5 19.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2368 PF10166.9 EDK41291.2 - 0.27 10.8 1.5 0.27 10.8 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) PriX PF18689.1 EDK41292.2 - 0.031 14.6 0.1 0.16 12.4 0.1 2.0 1 1 1 2 2 2 0 Primase X DnaG_DnaB_bind PF08278.11 EDK41292.2 - 0.18 12.4 0.0 0.38 11.4 0.0 1.5 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Fmp27 PF10344.9 EDK41293.2 - 2.4e-186 621.5 35.3 5.4e-186 620.4 35.3 1.6 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 EDK41293.2 - 3.7e-106 355.9 12.3 3.7e-106 355.9 12.3 2.5 2 1 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EDK41293.2 - 3.1e-58 196.3 0.0 1e-57 194.7 0.0 2.0 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EDK41293.2 - 6.1e-43 146.4 0.4 2e-42 144.7 0.4 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EDK41293.2 - 1e-21 77.6 2.8 2.8e-21 76.2 0.1 3.3 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain RabGAP-TBC PF00566.18 EDK41294.2 - 1.1e-52 178.8 0.9 1.1e-52 178.8 0.9 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 EDK41294.2 - 1.5e-09 37.7 0.1 5.7e-09 35.9 0.1 2.0 2 0 0 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.8 EDK41294.2 - 0.0004 20.5 0.0 0.0014 18.8 0.0 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EF-hand_6 PF13405.6 EDK41294.2 - 0.052 13.5 2.2 0.38 10.8 0.1 3.5 4 0 0 4 4 4 0 EF-hand domain EF-hand_1 PF00036.32 EDK41294.2 - 0.097 12.3 0.1 1 9.1 0.1 2.7 2 0 0 2 2 2 0 EF hand Phage_connect_1 PF05135.13 EDK41294.2 - 0.22 12.0 3.1 4.1 8.0 0.1 3.6 3 1 0 3 3 3 0 Phage gp6-like head-tail connector protein AAA_23 PF13476.6 EDK41295.2 - 0.03 14.8 0.8 0.03 14.8 0.8 1.9 2 0 0 2 2 2 0 AAA domain Rho_Binding PF08912.11 EDK41295.2 - 0.14 13.0 12.4 0.064 14.1 9.4 2.1 2 0 0 2 2 2 0 Rho Binding OmpH PF03938.14 EDK41295.2 - 0.95 9.8 10.2 2.3 8.5 10.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4365 PF14280.6 EDK41296.2 - 0.085 12.8 0.0 0.097 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4365) DUF1770 PF08589.10 EDK41296.2 - 0.12 13.4 0.3 0.91 10.5 0.0 2.0 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1770) RNA_pol_A_bac PF01000.26 EDK41297.2 - 2.3e-30 105.2 0.0 3.6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDK41297.2 - 1.9e-17 62.4 0.0 2.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain His_biosynth PF00977.21 EDK41298.2 - 7.1e-28 97.6 0.1 8.5e-28 97.4 0.1 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF4602 PF15375.6 EDK41299.2 - 0.0023 18.3 20.5 0.018 15.4 20.5 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) Nop25 PF09805.9 EDK41299.2 - 0.018 15.5 2.5 0.018 15.5 2.5 2.4 3 0 0 3 3 3 0 Nucleolar protein 12 (25kDa) Cnd2 PF05786.14 EDK41300.2 - 2.8e-166 555.4 32.1 6.7e-165 550.9 32.1 2.0 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EDK41300.2 - 0.0043 17.3 0.0 0.0043 17.3 0.0 3.3 4 0 0 4 4 4 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Gag_p15 PF08723.10 EDK41300.2 - 0.02 15.1 0.3 0.057 13.6 0.0 1.8 2 0 0 2 2 2 0 Gag protein p15 Peptidase_M41 PF01434.18 EDK41301.2 - 3.4e-60 203.2 0.1 5.6e-60 202.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDK41301.2 - 5.5e-41 140.1 0.0 2.2e-40 138.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK41301.2 - 3.4e-06 26.7 0.0 8.5e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDK41301.2 - 1.8e-05 25.2 0.3 0.00019 21.9 0.3 2.3 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EDK41301.2 - 5.6e-05 22.5 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDK41301.2 - 0.00016 22.0 0.0 0.12 12.6 0.0 3.6 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EDK41301.2 - 0.00037 20.3 0.0 0.013 15.2 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDK41301.2 - 0.0011 19.0 0.2 0.0055 16.7 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDK41301.2 - 0.029 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 EDK41301.2 - 0.036 14.2 0.0 0.2 11.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) ATPase PF06745.13 EDK41301.2 - 0.04 13.3 0.1 0.56 9.5 0.1 2.2 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 EDK41301.2 - 0.053 12.9 0.2 0.11 11.9 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SpoU_sub_bind PF08032.12 EDK41301.2 - 0.053 13.8 0.0 23 5.3 0.0 2.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding AAA_25 PF13481.6 EDK41301.2 - 0.077 12.6 0.7 0.94 9.0 0.5 2.4 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 EDK41301.2 - 0.089 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDK41301.2 - 0.13 11.8 0.2 0.83 9.1 0.2 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EDK41301.2 - 0.14 12.7 0.1 0.36 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDK41301.2 - 0.23 10.9 0.5 0.68 9.3 0.5 1.7 1 0 0 1 1 1 0 PhoH-like protein HLH PF00010.26 EDK41302.2 - 1.3e-12 47.5 0.1 2.6e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain FlgD PF03963.14 EDK41303.2 - 0.012 15.9 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook capping protein - N-terminal region SopA PF13981.6 EDK41303.2 - 0.047 14.1 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 SopA-like central domain YmgD PF16456.5 EDK41303.2 - 0.14 12.3 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 YmgD protein DUF4718 PF15842.5 EDK41306.2 - 0.13 12.0 0.8 0.22 11.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) zf-C2H2_10 PF16588.5 EDK41306.2 - 0.49 10.2 4.4 1.4 8.7 4.4 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger Carn_acyltransf PF00755.20 EDK41307.2 - 2.5e-145 485.4 0.0 3e-145 485.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-C2H2 PF00096.26 EDK41308.2 - 2e-12 46.8 28.0 1.6e-06 28.2 1.2 4.3 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK41308.2 - 1.2e-10 41.3 19.4 2e-08 34.3 1.0 5.0 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EDK41308.2 - 1.4e-09 37.7 8.4 1.2e-05 25.1 1.1 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDK41308.2 - 8.2e-08 32.5 26.5 0.00035 21.2 1.0 4.4 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDK41308.2 - 4e-07 30.1 2.9 0.092 13.1 0.7 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 EDK41308.2 - 0.00036 20.1 0.6 0.24 11.0 0.0 2.8 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 EDK41308.2 - 0.0081 16.3 0.7 0.027 14.6 0.7 2.0 1 1 0 1 1 1 1 Zinc ribbon domain GAGA PF09237.11 EDK41308.2 - 0.026 14.3 1.3 1.4 8.8 0.3 2.8 1 1 1 2 2 2 0 GAGA factor zf-C2HC_2 PF13913.6 EDK41308.2 - 0.041 13.8 6.6 0.26 11.2 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type C1_4 PF07975.12 EDK41308.2 - 0.05 13.8 1.0 0.19 12.0 1.0 2.1 1 0 0 1 1 1 0 TFIIH C1-like domain zf-LYAR PF08790.11 EDK41308.2 - 0.23 11.4 3.9 4.7 7.2 0.1 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger XPA_N PF01286.18 EDK41308.2 - 0.4 10.8 3.5 9.2 6.4 0.1 3.2 4 0 0 4 4 4 0 XPA protein N-terminal Zip PF02535.22 EDK41308.2 - 1.2 8.3 4.2 1.6 7.9 4.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter zf-C2HE PF16278.5 EDK41308.2 - 1.5 9.4 7.9 3.8 8.0 0.3 3.8 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EDK41308.2 - 1.5 8.6 10.3 10 6.0 0.1 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type Zf_RING PF16744.5 EDK41308.2 - 2.4 8.3 6.8 58 3.9 0.8 3.3 1 1 2 3 3 3 0 KIAA1045 RING finger Presenilin PF01080.17 EDK41308.2 - 5.4 5.7 6.9 7.1 5.3 6.9 1.3 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 EDK41308.2 - 7.1 4.8 21.2 9.6 4.3 21.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Putative_PNPOx PF01243.20 EDK41309.2 - 1.2e-13 51.1 0.0 4.9e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EDK41309.2 - 0.00022 21.3 0.0 0.0013 18.7 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Cas_Cas5d PF09704.10 EDK41309.2 - 0.013 15.4 0.0 0.015 15.2 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) Pyrid_ox_like PF16242.5 EDK41309.2 - 0.019 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like baeRF_family8 PF18851.1 EDK41309.2 - 0.036 14.1 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 F420H2_quin_red PF04075.14 EDK41309.2 - 0.073 13.2 0.1 0.67 10.1 0.0 2.0 1 1 1 2 2 2 0 F420H(2)-dependent quinone reductase ORC4_C PF14629.6 EDK41310.2 - 9.7e-50 169.0 1.3 9.7e-50 169.0 1.3 1.6 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EDK41310.2 - 3.6e-13 50.2 0.0 6.1e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDK41310.2 - 1.8e-09 38.0 0.0 4.8e-09 36.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EDK41310.2 - 5.3e-08 33.4 0.2 2.2e-07 31.4 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EDK41310.2 - 6e-07 29.6 0.2 1.1e-06 28.8 0.2 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TniB PF05621.11 EDK41310.2 - 5.4e-06 25.9 0.2 4.1e-05 23.1 0.2 2.1 1 1 0 1 1 1 1 Bacterial TniB protein AAA_14 PF13173.6 EDK41310.2 - 0.00055 20.0 0.7 0.0099 15.9 0.7 2.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDK41310.2 - 0.004 17.1 0.0 0.0087 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EDK41310.2 - 0.0062 16.1 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 EDK41310.2 - 0.0094 16.3 0.0 0.025 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain MCRS_N PF13325.6 EDK41310.2 - 0.011 15.7 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein AAA_24 PF13479.6 EDK41310.2 - 0.023 14.4 0.1 0.64 9.7 0.1 2.6 2 1 1 3 3 3 0 AAA domain NTPase_1 PF03266.15 EDK41310.2 - 0.024 14.5 0.7 0.16 11.8 0.2 2.3 2 1 0 2 2 2 0 NTPase AAA_33 PF13671.6 EDK41310.2 - 0.027 14.6 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EDK41310.2 - 0.028 14.7 0.1 0.33 11.2 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA-ATPase_like PF09820.9 EDK41310.2 - 0.029 13.8 1.5 0.042 13.3 0.5 1.8 2 1 0 2 2 2 0 Predicted AAA-ATPase AAA_2 PF07724.14 EDK41310.2 - 0.03 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RGS PF00615.19 EDK41311.2 - 1.5e-14 54.2 0.0 5.4e-14 52.5 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 EDK41311.2 - 0.13 12.4 0.0 0.47 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) eIF2_C PF09173.11 EDK41312.1 - 1.6e-34 118.0 0.6 3.6e-34 116.9 0.6 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDK41312.1 - 6.9e-23 81.2 0.7 5.5e-22 78.3 0.7 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDK41312.1 - 7.6e-11 42.2 1.7 1e-10 41.8 0.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK41312.1 - 0.0025 17.9 0.0 0.0053 16.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK41312.1 - 0.0034 17.3 0.1 0.035 14.0 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase ProQ_C PF17516.2 EDK41312.1 - 0.018 14.5 0.5 0.039 13.4 0.5 1.6 1 0 0 1 1 1 0 ProQ C-terminal domain MMR_HSR1_Xtn PF16897.5 EDK41312.1 - 0.09 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EDK41312.1 - 0.17 11.9 0.5 0.83 9.7 0.0 2.4 2 1 0 2 2 2 0 Dynamin family Zn_clus PF00172.18 EDK41313.2 - 2.4e-08 34.0 11.5 3.9e-08 33.3 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt5_N PF11942.8 EDK41313.2 - 0.1 13.6 2.7 0.14 13.2 1.2 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal MFS_1 PF07690.16 EDK41314.2 - 1.3e-29 103.2 46.4 7.4e-27 94.2 22.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDK41314.2 - 6.7e-14 51.3 13.9 9.9e-08 31.0 5.2 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EDK41314.2 - 2e-07 30.3 6.5 2e-07 30.3 6.5 2.3 1 1 1 2 2 2 1 MFS_1 like family Sugar_tr PF00083.24 EDK41314.2 - 2.7e-07 29.8 2.3 2.7e-07 29.8 2.3 2.4 2 1 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EDK41314.2 - 0.0031 15.9 2.0 0.0031 15.9 2.0 2.8 3 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EDK41314.2 - 0.016 13.7 0.2 0.016 13.7 0.2 2.5 3 0 0 3 3 3 0 Transmembrane secretion effector AA_permease PF00324.21 EDK41315.2 - 6.6e-122 407.5 41.2 8e-122 407.2 41.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK41315.2 - 1.1e-38 133.2 43.3 1.3e-38 133.0 43.3 1.0 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_7 PF13508.7 EDK41316.2 - 8.4e-07 29.3 0.5 2.9e-06 27.6 0.5 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDK41316.2 - 4.6e-05 23.6 0.3 0.00013 22.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDK41316.2 - 0.0001 22.2 0.3 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDK41316.2 - 0.00017 21.7 3.2 0.024 14.7 0.0 2.9 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDK41316.2 - 0.0087 16.2 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EDK41316.2 - 0.022 15.4 0.0 0.053 14.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK41316.2 - 0.051 13.6 0.1 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 FR47-like protein IFN-gamma PF00714.17 EDK41316.2 - 0.11 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Interferon gamma Orexin_rec2 PF03827.13 EDK41316.2 - 0.25 11.4 1.4 1.2 9.2 0.5 2.5 3 0 0 3 3 3 0 Orexin receptor type 2 CYSTM PF12734.7 EDK41317.2 - 2.1e-06 28.0 54.9 4.7e-05 23.6 41.9 4.6 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance MFS_1 PF07690.16 EDK41318.1 - 2.9e-26 92.2 25.5 2.9e-26 92.2 25.5 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 EDK41318.1 - 0.3 11.4 0.1 0.3 11.4 0.1 4.1 3 2 0 4 4 4 0 Domain of unknown function (DUF1772) Ribosomal_S7 PF00177.21 EDK41319.1 - 3.6e-35 120.8 3.3 5.3e-35 120.3 3.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Lyase_1 PF00206.20 EDK41319.1 - 0.001 18.5 0.0 0.0017 17.8 0.0 1.3 1 1 0 1 1 1 1 Lyase MFS_1 PF07690.16 EDK41320.2 - 7.3e-16 58.0 31.2 7.3e-16 58.0 31.2 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EDK41320.2 - 1.5e-05 23.7 15.8 1.5e-05 23.7 15.8 2.3 1 1 1 2 2 2 2 MFS/sugar transport protein DNA_ligase_A_M PF01068.21 EDK41320.2 - 0.02 14.5 0.1 0.03 14.0 0.1 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase domain PRA1 PF03208.19 EDK41320.2 - 0.84 9.3 12.0 0.16 11.6 2.3 3.0 2 1 1 3 3 3 0 PRA1 family protein IspA PF04279.15 EDK41320.2 - 6 7.0 14.1 0.9 9.7 1.5 3.2 3 1 0 3 3 3 0 Intracellular septation protein A Spore_YtrH PF14034.6 EDK41320.2 - 9.5 6.4 10.2 0.21 11.8 0.3 2.7 3 0 0 3 3 3 0 Sporulation protein YtrH AAA PF00004.29 EDK41321.2 - 5.2e-42 143.4 0.0 9e-42 142.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDK41321.2 - 1.2e-29 102.0 0.1 7.6e-29 99.5 0.1 2.4 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EDK41321.2 - 2.2e-22 78.9 6.0 5.1e-22 77.7 6.0 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EDK41321.2 - 2.3e-07 30.5 0.0 8.5e-07 28.7 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain RNA_helicase PF00910.22 EDK41321.2 - 2.8e-06 27.7 1.1 0.011 16.1 0.0 3.8 4 0 0 4 4 3 1 RNA helicase AAA_16 PF13191.6 EDK41321.2 - 4.1e-06 27.3 0.2 0.00012 22.5 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EDK41321.2 - 8e-06 25.9 0.0 3.5e-05 23.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDK41321.2 - 2.4e-05 24.1 0.0 4.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDK41321.2 - 4.3e-05 23.3 0.0 0.00012 21.9 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EDK41321.2 - 8.1e-05 21.9 0.0 0.00052 19.3 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDK41321.2 - 0.0001 22.6 0.5 0.0041 17.4 0.1 2.7 2 1 0 2 2 1 1 AAA domain TIP49 PF06068.13 EDK41321.2 - 0.00024 20.5 0.0 0.00042 19.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 EDK41321.2 - 0.0005 20.1 0.0 0.0014 18.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EDK41321.2 - 0.00055 20.5 0.0 0.0017 18.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDK41321.2 - 0.00072 19.7 0.0 0.0029 17.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDK41321.2 - 0.0015 18.7 0.0 0.0044 17.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EDK41321.2 - 0.0033 17.2 0.0 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDK41321.2 - 0.0091 15.6 0.1 0.38 10.3 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDK41321.2 - 0.012 16.0 0.1 0.051 14.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDK41321.2 - 0.028 13.8 0.0 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EDK41321.2 - 0.037 13.5 0.7 0.089 12.3 0.0 2.0 2 1 0 2 2 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EDK41321.2 - 0.058 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Torsin PF06309.11 EDK41321.2 - 0.06 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Torsin PhoH PF02562.16 EDK41321.2 - 0.067 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EDK41321.2 - 0.078 12.9 0.0 0.64 9.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EDK41321.2 - 0.08 12.6 0.0 0.21 11.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Bac_DnaA PF00308.18 EDK41321.2 - 0.085 12.7 0.0 0.62 9.9 0.0 2.1 1 1 0 1 1 1 0 Bacterial dnaA protein ATPase PF06745.13 EDK41321.2 - 0.11 11.8 0.0 4.4 6.6 0.0 2.4 1 1 1 2 2 2 0 KaiC Cytidylate_kin PF02224.18 EDK41321.2 - 0.17 11.6 0.7 0.52 10.0 0.1 2.1 2 1 1 3 3 3 0 Cytidylate kinase DUF2098 PF09871.9 EDK41321.2 - 0.22 11.9 2.1 0.44 10.9 2.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) NCBP3 PF10309.9 EDK41322.1 - 1.6e-27 95.2 0.3 3e-27 94.2 0.3 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Collagen_bind PF05737.12 EDK41322.1 - 0.0075 16.4 0.4 0.014 15.6 0.4 1.4 1 0 0 1 1 1 1 Collagen binding domain PIG-U PF06728.13 EDK41323.2 - 1.1e-77 261.6 19.4 1.3e-77 261.5 19.4 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Peptidase_M16 PF00675.20 EDK41324.1 - 8e-18 64.8 0.2 2.3e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDK41324.1 - 2.4e-07 30.9 0.0 5.6e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase M16 inactive domain Marek_SORF3 PF07153.11 EDK41326.2 - 0.083 12.2 0.7 0.14 11.5 0.1 1.6 2 0 0 2 2 2 0 Marek's disease-like virus SORF3 protein RNA_pol_Rpb6 PF01192.22 EDK41327.1 - 7.7e-15 54.6 0.1 1.2e-14 53.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 EF-hand_6 PF13405.6 EDK41328.2 - 0.00027 20.6 1.6 0.0085 16.0 0.1 3.4 4 1 1 5 5 5 1 EF-hand domain EF-hand_7 PF13499.6 EDK41328.2 - 0.0017 18.7 1.1 0.0042 17.5 0.2 2.2 2 1 0 2 2 2 1 EF-hand domain pair Actin PF00022.19 EDK41329.1 - 1.3e-124 416.0 0.0 8.2e-124 413.3 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDK41329.1 - 0.016 14.1 0.3 2.5 6.8 0.1 2.4 2 1 0 2 2 2 0 MreB/Mbl protein UPRTase PF14681.6 EDK41330.1 - 2e-75 252.8 0.0 2.6e-75 252.4 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EDK41330.1 - 0.027 14.0 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase domain CAP_GLY PF01302.25 EDK41331.2 - 5.1e-22 77.7 0.9 9.5e-22 76.8 0.9 1.5 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EDK41331.2 - 1.3e-17 64.0 0.0 2.4e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUF3052 PF11253.8 EDK41331.2 - 0.0029 17.5 0.2 0.0053 16.7 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3052) UPF0560 PF10577.9 EDK41331.2 - 0.087 11.3 0.3 0.11 11.0 0.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PGA2 PF07543.12 EDK41332.2 - 2.5e-08 34.0 10.1 2.2e-05 24.4 2.5 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 EOS1 PF12326.8 EDK41332.2 - 0.065 13.2 0.1 0.077 12.9 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein HemY_N PF07219.13 EDK41332.2 - 0.084 13.1 0.4 0.12 12.6 0.4 1.2 1 0 0 1 1 1 0 HemY protein N-terminus OmpH PF03938.14 EDK41332.2 - 0.12 12.7 6.9 0.15 12.4 6.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WD40 PF00400.32 EDK41333.2 - 2e-18 66.4 2.8 6.4e-07 30.0 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK41333.2 - 0.0013 19.0 0.1 0.15 12.4 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PHTB1_N PF14727.6 EDK41333.2 - 0.012 15.1 0.0 0.62 9.4 0.0 2.3 2 0 0 2 2 2 0 PTHB1 N-terminus RNA_pol_3_Rpc31 PF11705.8 EDK41334.2 - 2.1e-35 123.0 5.1 3.2e-35 122.4 5.1 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF2722 PF10846.8 EDK41334.2 - 0.27 10.2 2.6 0.4 9.6 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) C2 PF00168.30 EDK41335.2 - 3.7e-12 46.4 0.0 9.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain MRP-L20 PF12824.7 EDK41337.1 - 4.1e-50 170.2 1.0 4.6e-50 170.0 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_11 PF08279.12 EDK41337.1 - 0.019 14.9 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 HTH domain Neugrin PF06413.11 EDK41337.1 - 0.025 14.6 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Neugrin Ndc80_HEC PF03801.13 EDK41338.2 - 2.2e-47 160.5 0.1 8.1e-47 158.7 0.0 1.9 2 1 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 EDK41338.2 - 5.3e-08 32.8 0.4 5.3e-08 32.8 0.4 4.3 4 1 1 5 5 4 1 Domain of unknown function (DUF5595) KASH_CCD PF14662.6 EDK41338.2 - 0.0017 18.2 7.0 0.0017 18.2 7.0 3.0 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 EDK41338.2 - 0.004 17.2 21.0 0.68 10.0 2.4 5.5 3 2 2 6 6 5 1 Protein of unknown function (DUF1664) Spc7 PF08317.11 EDK41338.2 - 0.018 13.9 28.1 0.37 9.6 9.0 2.8 2 2 0 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EDK41338.2 - 0.02 14.9 25.4 0.82 9.7 10.0 4.0 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EDK41338.2 - 0.026 13.9 23.1 0.071 12.4 7.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EDK41338.2 - 0.034 14.2 26.2 0.25 11.4 7.0 3.9 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 EDK41338.2 - 0.037 14.4 13.0 0.36 11.2 0.1 5.5 3 2 3 6 6 6 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 EDK41338.2 - 0.042 14.3 19.0 0.037 14.4 3.4 4.2 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Tup_N PF08581.10 EDK41338.2 - 0.072 13.4 0.5 0.072 13.4 0.5 5.9 4 2 3 7 7 7 0 Tup N-terminal DUF3450 PF11932.8 EDK41338.2 - 0.089 12.1 26.4 1.8 7.8 1.2 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) Endotoxin_N PF03945.14 EDK41338.2 - 0.091 12.5 5.4 2.5 7.8 0.3 2.6 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain GP41 PF00517.17 EDK41338.2 - 0.12 12.3 1.4 0.27 11.1 1.4 1.5 1 0 0 1 1 1 0 Retroviral envelope protein LTXXQ PF07813.12 EDK41338.2 - 0.12 13.1 4.7 1.5 9.6 0.2 2.7 2 0 0 2 2 2 0 LTXXQ motif family protein LemA PF04011.12 EDK41338.2 - 0.22 11.4 11.9 0.3 10.9 8.4 2.6 2 1 0 2 2 2 0 LemA family NPV_P10 PF05531.12 EDK41338.2 - 0.23 11.9 6.7 4.7 7.8 0.2 4.6 3 1 2 5 5 4 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 EDK41338.2 - 0.34 11.5 19.9 0.32 11.6 2.4 5.1 4 1 1 5 5 5 0 SlyX zf-C4H2 PF10146.9 EDK41338.2 - 0.36 11.1 23.0 0.7 10.2 5.1 3.3 1 1 2 3 3 3 0 Zinc finger-containing protein DUF5082 PF16888.5 EDK41338.2 - 0.44 10.8 28.1 0.92 9.8 1.3 5.8 3 3 3 6 6 6 0 Domain of unknown function (DUF5082) Mt_ATP-synt_D PF05873.12 EDK41338.2 - 0.5 10.2 16.9 0.28 11.0 0.3 4.2 2 2 2 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) Cytochrom_B562 PF07361.11 EDK41338.2 - 0.64 10.7 7.8 1.4 9.6 0.6 3.6 2 1 2 4 4 3 0 Cytochrome b562 Tropomyosin_1 PF12718.7 EDK41338.2 - 0.67 10.1 26.5 1.6 8.9 8.3 3.8 2 2 1 3 3 3 0 Tropomyosin like Fzo_mitofusin PF04799.13 EDK41338.2 - 1.1 8.7 11.9 4.7 6.7 0.0 3.6 3 1 0 3 3 3 0 fzo-like conserved region APG6_N PF17675.1 EDK41338.2 - 1.6 9.3 29.5 4.4 7.9 4.4 3.9 2 2 1 3 3 3 0 Apg6 coiled-coil region ZapB PF06005.12 EDK41338.2 - 2 8.9 24.3 17 5.9 0.0 5.3 3 2 0 3 3 3 0 Cell division protein ZapB DUF16 PF01519.16 EDK41338.2 - 2.1 8.9 18.1 0.33 11.4 5.1 4.2 2 2 0 2 2 2 0 Protein of unknown function DUF16 YtxH PF12732.7 EDK41338.2 - 2.4 8.8 8.6 2.9 8.5 0.2 4.2 3 2 1 4 4 4 0 YtxH-like protein RNA_polI_A14 PF08203.11 EDK41338.2 - 2.9 8.7 8.2 0.21 12.4 1.2 2.7 3 0 0 3 3 1 0 Yeast RNA polymerase I subunit RPA14 Fez1 PF06818.15 EDK41338.2 - 3.1 8.2 26.0 2.5 8.5 10.4 2.6 2 1 1 3 3 3 0 Fez1 Baculo_PEP_C PF04513.12 EDK41338.2 - 3.6 7.6 12.7 7.1 6.7 1.3 3.7 2 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Gp-FAR-1 PF05823.12 EDK41338.2 - 3.8 7.9 9.6 4.4 7.6 3.1 3.3 2 2 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HALZ PF02183.18 EDK41338.2 - 3.8 7.8 10.3 13 6.1 0.1 4.9 5 1 0 5 5 4 0 Homeobox associated leucine zipper Mito_fiss_reg PF05308.11 EDK41338.2 - 4 7.4 11.3 7.1 6.6 2.4 2.7 1 1 2 3 3 3 0 Mitochondrial fission regulator FliD_C PF07195.12 EDK41338.2 - 4.2 6.7 14.2 13 5.1 0.1 3.7 3 2 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus TMF_TATA_bd PF12325.8 EDK41338.2 - 5.6 7.2 23.5 0.77 10.0 0.8 4.9 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 EDK41338.2 - 6.7 7.0 20.9 8.8 6.6 3.5 5.0 2 2 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain LPP PF04728.13 EDK41338.2 - 6.9 7.1 14.4 22 5.5 0.8 5.0 4 1 0 4 4 4 0 Lipoprotein leucine-zipper DNA_repr_REX1B PF14966.6 EDK41338.2 - 8.8 7.1 13.8 1.4 9.7 0.4 4.2 2 2 2 4 4 4 0 DNA repair REX1-B YabA PF06156.13 EDK41338.2 - 9.6 6.9 19.2 13 6.4 0.7 4.6 2 2 2 4 4 4 0 Initiation control protein YabA DUF4698 PF15769.5 EDK41339.2 - 2.4 7.1 6.1 4.5 6.2 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Mannosidase_ig PF17786.1 EDK41340.2 - 1.4e-09 38.4 0.0 5.7e-09 36.5 0.0 2.1 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EDK41340.2 - 1.1e-07 32.5 0.0 3.2e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EDK41340.2 - 0.00036 20.5 0.0 0.0013 18.7 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 EDK41340.2 - 0.029 14.1 0.0 0.095 12.5 0.0 1.8 1 0 0 1 1 1 0 Ig-fold domain FlgD_ig PF13860.6 EDK41340.2 - 0.12 12.3 0.6 19 5.2 0.1 2.6 2 0 0 2 2 2 0 FlgD Ig-like domain DRE2_N PF16803.5 EDK41341.1 - 1.7e-35 122.1 0.0 3e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus CIAPIN1 PF05093.13 EDK41341.1 - 0.0032 17.9 1.0 0.0066 16.9 0.1 1.9 2 0 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis HMG_box PF00505.19 EDK41342.2 - 4.3e-17 62.3 1.2 9.4e-17 61.2 1.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDK41342.2 - 1.6e-07 31.8 0.3 1.6e-07 31.8 0.3 2.0 2 0 0 2 2 2 1 HMG-box domain FAM60A PF15396.6 EDK41342.2 - 0.044 13.8 5.6 0.096 12.7 5.6 1.5 1 0 0 1 1 1 0 Protein Family FAM60A ABC2_membrane_3 PF12698.7 EDK41342.2 - 0.78 8.8 2.8 0.26 10.4 0.3 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein Presenilin PF01080.17 EDK41342.2 - 1.1 8.0 4.3 1.3 7.7 4.3 1.3 1 0 0 1 1 1 0 Presenilin COG2 PF06148.11 EDK41343.2 - 8.9e-19 67.9 1.1 8.9e-19 67.9 1.1 1.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EDK41343.2 - 0.00084 19.4 3.1 0.0066 16.5 0.8 2.8 1 1 1 2 2 2 1 Vps51/Vps67 CX9C PF16860.5 EDK41344.2 - 0.004 17.1 2.2 0.004 17.1 2.2 2.2 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Colipase-like PF15083.6 EDK41344.2 - 0.015 15.4 5.7 0.023 14.8 5.7 1.3 1 0 0 1 1 1 0 Colipase-like CHCH PF06747.13 EDK41344.2 - 0.02 15.0 11.3 0.15 12.2 4.1 2.5 2 0 0 2 2 2 0 CHCH domain HALZ PF02183.18 EDK41344.2 - 0.028 14.7 1.5 0.029 14.6 0.2 1.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper COX6B PF02297.17 EDK41344.2 - 3.4 8.0 9.0 6.1 7.2 3.0 2.3 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Nup54 PF13874.6 EDK41346.2 - 5.2e-35 120.6 2.1 7.3e-35 120.1 0.1 2.1 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EDK41346.2 - 3e-24 85.7 151.6 2.4e-12 47.5 40.4 5.3 1 1 4 5 5 5 5 Nucleoporin FG repeat region Nup54_C PF18437.1 EDK41346.2 - 0.023 14.6 0.8 0.048 13.6 0.8 1.4 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain DUF3760 PF12586.8 EDK41347.2 - 0.12 12.5 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) HA2 PF04408.23 EDK41348.2 - 1.4e-19 70.4 0.1 9.8e-19 67.6 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDK41348.2 - 1.1e-14 54.7 0.0 3.5e-14 53.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDK41348.2 - 7.5e-14 51.9 0.2 2.4e-13 50.2 0.2 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDK41348.2 - 3e-08 33.6 0.1 7.7e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDK41348.2 - 1.2e-05 25.5 0.1 3.7e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDK41348.2 - 0.00046 19.5 0.8 0.00085 18.7 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 EDK41348.2 - 0.0044 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain ABC_tran PF00005.27 EDK41348.2 - 0.033 14.7 0.8 0.38 11.3 0.0 2.9 3 0 0 3 3 2 0 ABC transporter AAA_19 PF13245.6 EDK41348.2 - 0.06 13.7 0.2 0.28 11.5 0.1 2.2 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EDK41348.2 - 0.064 12.3 0.1 0.13 11.2 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EDK41348.2 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 EDK41348.2 - 0.087 12.3 0.0 0.33 10.4 0.0 2.0 1 0 0 1 1 1 0 PhoH-like protein Pantoate_ligase PF02569.15 EDK41349.2 - 4.1e-98 327.8 0.1 4.7e-98 327.6 0.1 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase CTP_transf_like PF01467.26 EDK41349.2 - 0.15 12.3 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 Cytidylyltransferase-like Abhydrolase_6 PF12697.7 EDK41350.2 - 3e-12 47.6 0.0 3.9e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK41350.2 - 2.3e-07 30.3 0.0 3.5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK41350.2 - 0.00037 20.2 0.1 0.00081 19.1 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EDK41350.2 - 0.00089 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EDK41350.2 - 0.025 14.1 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family PAF-AH_p_II PF03403.13 EDK41350.2 - 0.058 11.9 0.0 0.1 11.1 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II SRP40_C PF05022.12 EDK41351.1 - 1.5e-24 86.7 2.4 3.4e-24 85.5 2.4 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain ERCC3_RAD25_C PF16203.5 EDK41352.2 - 1.2e-125 417.7 1.3 2.6e-125 416.6 1.3 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EDK41352.2 - 8.5e-35 119.7 0.1 2.4e-34 118.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41352.2 - 2.5e-16 60.2 0.0 4.9e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDK41352.2 - 5.8e-13 49.2 0.1 1.4e-12 47.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EDK41352.2 - 2.4e-08 33.1 0.0 2.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EDK41352.2 - 6.2e-05 22.8 0.1 0.00019 21.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 EDK41352.2 - 0.019 14.4 0.0 0.047 13.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein DUF1681 PF07933.14 EDK41353.2 - 0.0024 17.6 0.0 0.022 14.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1681) Aldedh PF00171.22 EDK41354.2 - 2.6e-73 247.1 0.0 3.1e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SEA PF01390.20 EDK41354.2 - 0.088 12.9 0.0 0.84 9.8 0.0 2.4 2 0 0 2 2 2 0 SEA domain Ribosomal_S21 PF01165.20 EDK41355.2 - 7.2e-10 38.4 1.9 1.3e-09 37.6 1.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 Mito_carr PF00153.27 EDK41356.2 - 5.9e-46 154.3 7.2 6.6e-18 64.4 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein RNA_pol_Rpc82 PF05645.13 EDK41359.2 - 3.9e-68 230.0 0.8 7e-67 225.9 0.4 2.1 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EDK41359.2 - 2.5e-18 65.9 2.3 5.2e-18 64.9 0.6 2.4 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EDK41359.2 - 2.8e-05 23.9 0.5 0.17 11.8 0.0 3.6 3 0 0 3 3 3 2 TFIIE alpha subunit TrmB PF01978.19 EDK41359.2 - 0.011 15.6 1.8 0.053 13.4 0.0 3.0 5 0 0 5 5 5 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 EDK41359.2 - 0.24 11.0 1.9 0.66 9.6 0.1 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 EDK41359.2 - 0.4 10.6 2.4 8.4 6.4 0.1 2.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family TPR_2 PF07719.17 EDK41360.2 - 1.4e-23 81.0 33.1 7.3e-06 25.7 0.1 15.3 18 0 0 18 18 18 4 Tetratricopeptide repeat TPR_8 PF13181.6 EDK41360.2 - 1.5e-22 77.8 17.6 0.00029 20.8 0.0 12.6 13 0 0 13 13 12 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDK41360.2 - 8.1e-22 77.5 8.1 1.6e-05 25.3 0.0 10.5 8 3 3 11 11 11 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDK41360.2 - 9.8e-22 75.8 27.5 1e-05 25.1 0.1 13.0 13 2 0 13 13 13 5 Tetratricopeptide repeat TPR_11 PF13414.6 EDK41360.2 - 1.1e-21 76.2 15.7 0.0011 18.6 0.0 12.0 12 1 1 13 13 13 6 TPR repeat TPR_14 PF13428.6 EDK41360.2 - 1.7e-19 68.9 3.9 2.5e-05 24.7 0.0 10.9 10 0 0 10 10 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK41360.2 - 4.9e-16 58.7 10.7 1.6e-06 28.2 0.0 7.3 5 3 4 9 9 9 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDK41360.2 - 9.8e-16 56.9 9.4 0.0042 17.4 0.1 11.0 12 0 0 12 12 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDK41360.2 - 1.3e-14 54.0 0.1 0.03 14.5 0.0 7.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDK41360.2 - 9.6e-14 51.8 19.0 0.011 16.3 0.1 9.2 7 3 3 11 11 11 4 Tetratricopeptide repeat TPR_12 PF13424.6 EDK41360.2 - 7.2e-13 48.6 27.1 0.023 15.0 0.0 10.6 9 3 3 12 12 11 5 Tetratricopeptide repeat TPR_22 PF18833.1 EDK41360.2 - 5.7e-10 39.2 0.0 2.1e-09 37.4 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDK41360.2 - 5.5e-09 36.1 4.8 25 5.8 0.1 9.1 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EDK41360.2 - 1.1e-06 28.2 5.0 0.39 10.0 0.0 5.9 4 3 3 7 7 7 2 MalT-like TPR region TPR_7 PF13176.6 EDK41360.2 - 1.2e-05 25.0 17.6 0.0062 16.5 0.0 9.4 12 0 0 12 12 11 1 Tetratricopeptide repeat NARP1 PF12569.8 EDK41360.2 - 0.0001 21.4 0.3 0.0096 14.9 0.0 3.3 3 0 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EDK41360.2 - 0.00067 20.0 0.5 2.7 8.9 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDK41360.2 - 0.024 13.8 11.3 4.5 6.4 0.0 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EDK41360.2 - 0.045 13.4 0.0 1.5 8.5 0.0 3.2 3 0 0 3 3 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 EDK41360.2 - 0.066 13.1 0.1 0.066 13.1 0.1 5.9 8 0 0 8 8 6 0 Tetratricopeptide repeat ATG13 PF10033.9 EDK41361.2 - 1.8e-66 224.3 0.0 4.3e-66 223.0 0.0 1.6 2 0 0 2 2 2 1 Autophagy-related protein 13 Scytalone_dh PF02982.14 EDK41361.2 - 0.13 12.1 0.1 0.7 9.7 0.0 2.0 2 0 0 2 2 2 0 Scytalone dehydratase AFG1_ATPase PF03969.16 EDK41362.2 - 7e-78 262.0 0.0 2.1e-74 250.6 0.0 2.2 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EDK41362.2 - 1.7e-05 25.3 0.1 0.14 12.6 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 EDK41362.2 - 0.0012 18.8 0.0 0.0086 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EDK41362.2 - 0.011 16.1 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDK41362.2 - 0.023 15.0 0.1 0.16 12.2 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDK41362.2 - 0.046 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EDK41362.2 - 0.048 13.6 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EDK41362.2 - 0.064 13.6 0.0 0.27 11.7 0.0 2.2 1 1 0 1 1 1 0 RNA helicase TsaE PF02367.17 EDK41362.2 - 0.077 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EDK41362.2 - 0.08 12.8 0.3 0.62 9.9 0.0 2.2 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Heme_oxygenase PF01126.20 EDK41363.2 - 0.0061 16.4 0.0 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 Heme oxygenase DUF3274 PF11678.8 EDK41363.2 - 0.23 10.7 2.0 0.41 9.8 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3274) SBE2 PF17076.5 EDK41363.2 - 0.24 9.6 58.2 0.36 9.0 50.8 3.2 2 1 0 2 2 2 0 SBE2, cell-wall formation Suf PF05843.14 EDK41364.2 - 5.5e-13 49.6 17.3 0.00015 21.8 0.0 6.5 6 1 1 7 7 7 4 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDK41364.2 - 1.3e-09 38.1 0.0 2.1 9.4 0.0 6.5 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDK41364.2 - 3.9e-05 23.5 4.6 2.8 8.4 0.0 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EDK41364.2 - 5e-05 22.6 1.2 5e-05 22.6 1.2 4.3 4 2 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_17 PF13431.6 EDK41364.2 - 0.00012 22.2 1.6 20 5.8 0.0 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDK41364.2 - 0.00044 20.2 10.4 0.82 9.7 0.4 6.5 4 2 2 7 7 6 1 Mad3/BUB1 homology region 1 SNAP PF14938.6 EDK41364.2 - 0.00052 19.5 0.8 0.96 8.8 0.0 2.7 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP Peptidase_M3_N PF08439.10 EDK41364.2 - 0.0036 17.5 2.4 0.12 12.6 0.1 3.2 2 0 0 2 2 2 1 Oligopeptidase F TPR_2 PF07719.17 EDK41364.2 - 0.0056 16.7 1.8 7.5 6.9 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDK41364.2 - 0.1 12.9 0.0 72 3.8 0.0 3.9 3 1 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDK41364.2 - 0.11 12.7 0.6 16 5.8 0.0 3.2 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4363 PF14276.6 EDK41364.2 - 0.33 11.1 4.8 2.1 8.5 0.6 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4363) TPR_6 PF13174.6 EDK41364.2 - 1.2 9.9 7.6 87 4.1 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat ATP-synt_D PF01813.17 EDK41365.1 - 6.9e-71 238.1 5.3 9.4e-71 237.7 5.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit D FYDLN_acid PF09538.10 EDK41365.1 - 0.33 11.7 6.0 0.87 10.3 6.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PHM7_cyt PF14703.6 EDK41365.1 - 0.47 10.7 8.4 1.5 9.0 2.7 2.4 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter T3SSipB PF16535.5 EDK41365.1 - 9.7 6.6 12.3 9.7 6.7 4.9 2.4 2 1 0 2 2 2 0 Type III cell invasion protein SipB adh_short_C2 PF13561.6 EDK41366.1 - 2e-55 187.9 0.4 2.4e-55 187.7 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41366.1 - 3.6e-38 131.0 0.5 4.3e-38 130.7 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41366.1 - 1.1e-13 51.5 0.4 1.6e-13 51.0 0.4 1.1 1 0 0 1 1 1 1 KR domain HemS PF05171.12 EDK41366.1 - 0.083 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Haemin-degrading HemS.ChuX domain FAD_binding_2 PF00890.24 EDK41367.1 - 3.4e-123 411.8 3.0 4.3e-123 411.5 3.0 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EDK41367.1 - 2.2e-45 153.7 0.5 3.7e-45 153.0 0.5 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.17 EDK41367.1 - 2.4e-06 27.0 0.2 0.0022 17.3 0.0 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 EDK41367.1 - 1.1e-05 24.9 0.1 0.00014 21.3 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDK41367.1 - 1.4e-05 24.4 0.4 0.0012 18.0 0.7 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EDK41367.1 - 0.0031 16.8 0.5 0.0065 15.8 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EDK41367.1 - 0.015 14.9 1.1 0.038 13.6 1.1 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDK41367.1 - 0.03 13.1 0.0 0.12 11.0 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 EDK41367.1 - 0.045 12.8 0.1 1.1 8.2 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Antimicrobial_7 PF08102.11 EDK41367.1 - 0.11 12.7 0.2 8.5 6.7 0.1 2.6 2 0 0 2 2 2 0 Scorpion antimicrobial peptide Pyr_redox_3 PF13738.6 EDK41367.1 - 0.18 11.0 0.1 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.6 EDK41368.1 - 1.4e-63 214.6 0.0 1.7e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDK41368.1 - 6.7e-40 136.6 0.0 7.9e-40 136.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDK41368.1 - 3.1e-09 37.0 0.1 4.5e-09 36.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDK41368.1 - 0.00036 20.1 0.0 0.0019 17.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EDK41368.1 - 0.0024 18.1 0.0 0.004 17.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 EDK41368.1 - 0.019 15.5 0.0 0.048 14.2 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 EDK41368.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein GDP_Man_Dehyd PF16363.5 EDK41368.1 - 0.027 13.9 0.0 0.29 10.5 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EDK41368.1 - 0.042 13.2 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMN_dh PF01070.18 EDK41368.1 - 0.088 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Nro1 PF12753.7 EDK41369.2 - 0.062 12.2 1.6 0.093 11.7 1.6 1.1 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 CENP-B_dimeris PF09026.10 EDK41369.2 - 0.6 10.5 9.9 0.096 13.1 4.1 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EDK41369.2 - 3 7.1 4.9 0.82 8.9 1.8 1.6 2 0 0 2 2 2 0 NOA36 protein PX PF00787.24 EDK41370.2 - 5e-21 74.8 0.0 7.3e-21 74.3 0.0 1.2 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EDK41370.2 - 6.3e-07 29.2 0.0 9.7e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Vps5 C terminal like Vps5 PF09325.10 EDK41371.2 - 1.1e-68 231.3 12.4 1.3e-68 231.1 12.4 1.0 1 0 0 1 1 1 1 Vps5 C terminal like DUF496 PF04363.12 EDK41371.2 - 0.0004 20.4 1.9 0.0061 16.6 0.1 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF496) BAR PF03114.18 EDK41371.2 - 0.0018 17.9 7.8 0.0052 16.5 7.8 1.8 1 1 0 1 1 1 1 BAR domain Ax_dynein_light PF10211.9 EDK41371.2 - 0.0024 17.8 4.4 0.0024 17.8 4.4 1.5 2 0 0 2 2 2 1 Axonemal dynein light chain DHR10 PF18595.1 EDK41371.2 - 0.0034 17.4 9.5 0.0055 16.8 4.8 2.3 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain DivIC PF04977.15 EDK41371.2 - 0.012 15.4 5.2 0.043 13.6 2.6 2.5 2 0 0 2 2 2 0 Septum formation initiator TMF_TATA_bd PF12325.8 EDK41371.2 - 0.018 15.2 7.0 0.032 14.4 4.6 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 EDK41371.2 - 0.031 13.8 2.1 0.038 13.5 2.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2730 PF10805.8 EDK41371.2 - 0.036 14.2 2.1 2.6 8.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Glyco_hydro_125 PF06824.11 EDK41371.2 - 0.037 12.9 0.3 0.039 12.8 0.3 1.2 1 0 0 1 1 1 0 Metal-independent alpha-mannosidase (GH125) FH2 PF02181.23 EDK41371.2 - 0.042 13.0 9.2 0.12 11.5 5.1 2.1 2 0 0 2 2 2 0 Formin Homology 2 Domain Mod_r PF07200.13 EDK41371.2 - 0.084 13.0 11.6 0.15 12.2 6.8 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein COG5 PF10392.9 EDK41371.2 - 0.086 13.0 7.0 1.1 9.5 1.2 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 HrpB7 PF09486.10 EDK41371.2 - 0.1 13.0 0.5 0.27 11.6 0.3 1.7 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Sec8_exocyst PF04048.14 EDK41371.2 - 0.14 12.0 10.4 0.072 13.0 4.5 2.4 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Mt_ATP-synt_B PF05405.14 EDK41371.2 - 0.14 11.8 11.5 0.51 9.9 7.3 2.6 2 1 1 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) BAR_3 PF16746.5 EDK41371.2 - 0.15 11.7 11.6 0.21 11.2 9.7 2.0 1 1 1 2 2 2 0 BAR domain of APPL family Fez1 PF06818.15 EDK41371.2 - 0.16 12.4 8.8 0.27 11.7 8.8 1.5 1 1 0 1 1 1 0 Fez1 ATG16 PF08614.11 EDK41371.2 - 0.19 11.9 8.1 0.079 13.2 3.5 2.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Cauli_AT PF03233.13 EDK41371.2 - 0.2 11.6 7.0 0.067 13.1 3.8 1.9 2 1 0 2 2 2 0 Aphid transmission protein RIC3 PF15361.6 EDK41371.2 - 0.21 12.0 2.9 0.3 11.5 2.9 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 YabA PF06156.13 EDK41371.2 - 0.26 11.9 6.7 0.47 11.1 4.3 2.2 2 1 0 2 2 2 0 Initiation control protein YabA CLZ PF16526.5 EDK41371.2 - 0.52 10.7 6.4 1.7 9.0 4.6 2.6 2 2 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FliD_N PF02465.18 EDK41371.2 - 0.68 10.7 7.9 0.18 12.5 2.1 2.5 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF1664 PF07889.12 EDK41371.2 - 0.82 9.7 7.8 2.3 8.3 3.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Kinesin_assoc PF16183.5 EDK41371.2 - 0.88 9.7 4.4 1.6 8.9 4.3 1.6 1 1 0 1 1 1 0 Kinesin-associated BLOC1_2 PF10046.9 EDK41371.2 - 0.96 9.8 11.8 1.6 9.1 4.8 3.1 1 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 EDK41371.2 - 1.7 7.8 8.1 1.8 7.7 7.1 1.5 1 1 1 2 2 2 0 TMPIT-like protein Fib_alpha PF08702.10 EDK41371.2 - 6.1 7.0 9.6 5.2 7.2 6.0 2.3 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ACT_7 PF13840.6 EDK41372.2 - 2.5e-27 94.4 0.1 3e-14 52.5 0.0 2.8 2 1 0 2 2 2 2 ACT domain GYF PF02213.16 EDK41373.2 - 1.2e-15 56.9 0.2 2.8e-15 55.7 0.2 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EDK41373.2 - 8.9e-06 25.4 0.4 2.2e-05 24.2 0.1 1.9 2 0 0 2 2 2 1 GYF domain 2 RRP7 PF12923.7 EDK41373.2 - 0.043 13.9 0.5 1.6 8.9 0.3 2.7 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Phage_integrase PF00589.22 EDK41373.2 - 0.051 13.4 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family UMP1 PF05348.11 EDK41374.2 - 1.3e-39 135.0 0.1 1.6e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Nuc_sug_transp PF04142.15 EDK41375.2 - 3.4e-12 46.2 0.7 6.6e-12 45.2 0.7 1.6 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EDK41375.2 - 1.1e-08 35.3 26.3 2.9e-06 27.5 2.3 2.8 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EDK41375.2 - 1.5e-07 31.0 1.2 1.5e-07 31.0 1.2 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 EDK41375.2 - 2.5e-07 30.2 14.0 4.2e-07 29.5 13.9 1.4 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport UAA PF08449.11 EDK41375.2 - 4.6e-07 29.4 11.6 4.6e-07 29.4 11.6 1.7 2 0 0 2 2 2 1 UAA transporter family TMEM234 PF10639.9 EDK41375.2 - 0.00082 19.4 0.4 0.00082 19.4 0.4 2.6 2 0 0 2 2 2 1 Putative transmembrane family 234 YrhC PF14143.6 EDK41375.2 - 0.79 9.9 3.2 7.2 6.8 0.1 2.9 2 0 0 2 2 2 0 YrhC-like protein Multi_Drug_Res PF00893.19 EDK41375.2 - 3.1 8.5 12.8 4.8 7.9 0.5 2.8 2 0 0 2 2 2 0 Small Multidrug Resistance protein Fibrillarin PF01269.17 EDK41376.1 - 1.5e-104 348.1 0.0 1.8e-104 347.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EDK41376.1 - 2.9e-06 27.1 0.1 6.1e-06 26.1 0.1 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 EDK41376.1 - 0.016 15.3 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Shadoo PF14999.6 EDK41376.1 - 0.019 15.1 17.9 0.019 15.1 17.9 3.4 1 1 1 2 2 2 0 Shadow of prion protein, neuroprotective PCMT PF01135.19 EDK41376.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 EDK41376.1 - 0.11 12.2 0.0 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F zf-RING_UBOX PF13445.6 EDK41377.2 - 0.0011 18.9 1.1 0.0022 17.9 0.5 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDK41377.2 - 0.0019 18.1 2.6 0.0019 18.1 2.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDK41377.2 - 0.0019 18.0 2.3 0.002 17.9 0.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK41377.2 - 0.0041 16.9 0.1 0.012 15.5 0.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDK41377.2 - 0.022 14.9 2.0 0.024 14.8 0.1 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDK41377.2 - 0.024 14.5 1.5 0.047 13.6 0.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK41377.2 - 0.079 12.8 0.4 0.31 10.9 0.4 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Rtf2 PF04641.12 EDK41377.2 - 0.098 12.0 0.2 0.098 12.0 0.2 2.4 3 0 0 3 3 3 0 Rtf2 RING-finger zf-RING_2 PF13639.6 EDK41377.2 - 0.24 11.8 4.1 0.1 12.9 1.3 1.9 2 1 0 2 2 2 0 Ring finger domain Usp PF00582.26 EDK41378.2 - 4.9e-22 79.0 1.1 2.4e-21 76.7 0.0 2.3 2 1 0 2 2 2 1 Universal stress protein family TIP120 PF08623.10 EDK41378.2 - 0.036 13.8 0.9 0.11 12.3 0.9 1.8 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) UBA_4 PF14555.6 EDK41379.2 - 9.1e-15 54.2 0.1 1.9e-14 53.2 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EDK41379.2 - 3.4e-13 49.6 0.1 9.4e-13 48.2 0.0 1.8 2 0 0 2 2 2 1 UBX domain ArsP_2 PF11449.8 EDK41379.2 - 0.021 14.0 0.2 0.037 13.3 0.2 1.3 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter Metal_resist PF13801.6 EDK41379.2 - 2.1 8.6 5.0 0.98 9.6 2.0 1.9 1 1 1 2 2 2 0 Heavy-metal resistance BRCT_2 PF16589.5 EDK41380.2 - 0.063 13.7 0.2 0.11 12.9 0.2 1.4 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DAO PF01266.24 EDK41381.1 - 3.7e-54 184.6 0.0 5.1e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDK41381.1 - 8.5e-40 135.5 0.0 2e-39 134.3 0.0 1.7 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDK41381.1 - 3.4e-13 49.4 3.0 1.2e-12 47.7 3.0 1.7 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDK41381.1 - 8.9e-11 41.8 1.0 6.7e-06 25.7 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EDK41381.1 - 0.00025 20.2 0.4 0.013 14.6 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EDK41381.1 - 0.00033 20.0 1.4 0.0029 16.9 1.4 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDK41381.1 - 0.00053 19.3 0.7 0.32 10.2 0.0 2.4 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 EDK41381.1 - 0.0025 16.6 0.6 0.0048 15.7 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EDK41381.1 - 0.0053 16.1 0.7 0.021 14.1 0.7 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDK41381.1 - 0.025 14.8 0.4 0.07 13.4 0.4 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EDK41381.1 - 0.028 14.3 0.9 0.13 12.1 0.9 2.1 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDK41381.1 - 0.045 13.0 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EDK41381.1 - 0.047 12.9 0.3 0.14 11.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDK41381.1 - 0.05 14.0 0.0 0.17 12.4 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding IFRD PF05004.13 EDK41387.2 - 8.7e-24 84.2 3.9 5.8e-22 78.2 3.9 2.6 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) MCCD1 PF15707.5 EDK41387.2 - 0.009 16.5 0.4 0.038 14.5 0.4 2.0 1 0 0 1 1 1 1 Mitochondrial coiled-coil domain protein 1 Acetyltransf_1 PF00583.25 EDK41388.2 - 2.7e-09 37.3 0.0 3.6e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EDK41388.2 - 1.5e-06 28.1 0.0 2.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EDK41388.2 - 1.4e-05 25.1 0.1 2.4e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK41388.2 - 3.1e-05 24.3 0.0 4.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EDK41388.2 - 0.019 15.1 0.0 0.025 14.7 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Mcl1_mid PF12341.8 EDK41389.2 - 5.1e-78 262.4 0.0 2.7e-75 253.5 0.0 2.4 2 0 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EDK41389.2 - 2.5e-06 27.7 0.1 0.85 10.0 0.0 4.4 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDK41389.2 - 0.028 15.3 0.4 3.9e+02 2.2 0.0 5.7 6 1 1 7 7 7 0 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EDK41389.2 - 0.033 13.4 0.0 0.063 12.5 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus K_trans PF02705.16 EDK41390.2 - 3.6e-178 593.4 15.1 4.3e-178 593.2 15.1 1.0 1 0 0 1 1 1 1 K+ potassium transporter LSM14 PF12701.7 EDK41391.1 - 1.6e-27 95.4 0.0 2.3e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EDK41391.1 - 4.7e-06 26.7 0.0 7.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 EDK41391.1 - 0.0069 17.3 3.6 0.23 12.4 0.7 2.6 1 1 1 2 2 2 2 FDF domain API5 PF05918.11 EDK41391.1 - 0.16 10.7 2.7 0.23 10.2 2.7 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FoP_duplication PF13865.6 EDK41391.1 - 1.3 9.7 13.0 5.5 7.6 13.0 2.0 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Med26 PF08711.11 EDK41392.2 - 5.6e-09 35.9 0.0 1.4e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ribosom_S12_S23 PF00164.25 EDK41393.1 - 5.7e-51 170.9 0.2 7.3e-51 170.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Mito_carr PF00153.27 EDK41394.1 - 4.7e-51 170.7 0.1 3.9e-18 65.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein NDUF_B4 PF07225.12 EDK41394.1 - 0.13 12.2 0.1 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) ANAPC4_WD40 PF12894.7 EDK41395.2 - 0.033 14.5 0.4 5.6 7.3 0.1 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EDK41395.2 - 0.093 12.7 0.3 0.26 11.3 0.3 1.8 1 0 0 1 1 1 0 LisH DBR1 PF05011.13 EDK41396.2 - 3e-21 76.3 0.1 5.2e-21 75.5 0.1 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EDK41396.2 - 7.3e-07 29.9 0.1 1.1e-06 29.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDK41396.2 - 0.033 14.4 0.0 0.12 12.6 0.0 1.9 2 1 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain NAD_binding_1 PF00175.21 EDK41397.2 - 2.6e-29 102.1 0.0 4.4e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDK41397.2 - 3.4e-26 91.5 0.0 5.8e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDK41397.2 - 7.4e-07 29.4 0.1 0.00026 21.2 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Carb_kinase PF01256.17 EDK41398.2 - 6e-55 186.4 1.1 9.4e-54 182.5 1.1 2.0 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 EDK41398.2 - 0.00057 19.3 0.0 0.00091 18.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DIT1_PvcA PF05141.12 EDK41399.2 - 2.4 7.5 9.9 2.3 7.6 8.7 1.5 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein NAD_Gly3P_dh_N PF01210.23 EDK41400.1 - 3.1e-52 176.7 0.6 4.8e-52 176.1 0.1 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EDK41400.1 - 8.2e-42 142.8 0.1 1.7e-41 141.9 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 EDK41400.1 - 0.0034 17.9 0.0 0.13 12.9 0.0 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NUDIX PF00293.28 EDK41401.2 - 4.4e-12 46.2 0.0 1.1e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain HHV-1_VABD PF16852.5 EDK41401.2 - 0.013 15.4 5.9 0.86 9.7 0.6 2.6 2 0 0 2 2 2 0 Herpes viral adaptor-to-host cellular mRNA binding domain Presenilin PF01080.17 EDK41402.2 - 5.5 5.6 5.0 7.2 5.3 5.0 1.1 1 0 0 1 1 1 0 Presenilin Brix PF04427.18 EDK41403.2 - 2.7e-48 164.6 3.3 2.7e-48 164.6 3.3 1.5 2 0 0 2 2 2 1 Brix domain DEAD PF00270.29 EDK41404.2 - 1.5e-49 168.2 0.1 5e-49 166.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK41404.2 - 1.5e-31 109.0 0.0 7.8e-31 106.7 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41404.2 - 1.9e-08 34.5 0.0 9.2e-08 32.3 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDK41404.2 - 1.8e-05 24.1 0.1 4.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 EDK41404.2 - 0.00076 19.3 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain FYVE PF01363.21 EDK41405.2 - 1.3e-18 66.8 10.8 1.3e-18 66.8 10.8 3.2 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EDK41405.2 - 7e-09 35.9 2.2 7e-09 35.9 2.2 3.8 4 0 0 4 4 4 2 Ring finger domain zf-RING_11 PF17123.5 EDK41405.2 - 2.5e-06 27.1 3.2 2.5e-06 27.1 3.2 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDK41405.2 - 5.8e-05 22.8 1.9 5.8e-05 22.8 1.9 4.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDK41405.2 - 0.00044 19.8 2.7 0.00044 19.8 2.7 3.1 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EDK41405.2 - 0.0005 20.3 2.0 0.0005 20.3 2.0 3.1 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDK41405.2 - 0.00066 19.5 1.3 0.00066 19.5 1.3 4.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDK41405.2 - 0.0015 18.5 2.6 0.0015 18.5 2.6 3.5 3 1 0 3 3 3 1 RING-type zinc-finger zf-HC5HC2H PF13771.6 EDK41405.2 - 0.034 14.4 0.3 0.034 14.4 0.3 3.2 3 0 0 3 3 3 0 PHD-like zinc-binding domain zf-Di19 PF05605.12 EDK41405.2 - 0.44 10.9 6.2 1.1 9.6 0.1 3.0 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Med21 PF11221.8 EDK41406.2 - 9.8e-47 158.8 11.8 2.1e-46 157.7 11.8 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF2951 PF11166.8 EDK41406.2 - 0.047 13.9 0.3 0.084 13.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) PMT PF02366.18 EDK41407.2 - 1.1e-57 195.5 11.9 2.6e-57 194.2 11.9 1.7 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDK41407.2 - 1.4e-50 171.6 11.9 3e-50 170.6 11.9 1.5 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDK41407.2 - 1.9e-22 80.0 0.1 3e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 EDK41407.2 - 3.7e-05 24.0 10.8 3.7e-05 24.0 10.8 3.4 4 1 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase F-box-like PF12937.7 EDK41408.2 - 0.012 15.5 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like ApoO PF09769.9 EDK41410.2 - 5.7e-38 129.8 0.9 4.9e-37 126.8 0.1 2.1 2 0 0 2 2 2 1 Apolipoprotein O BCAS2 PF05700.11 EDK41410.2 - 0.045 13.5 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) OEP PF02321.18 EDK41410.2 - 0.063 13.1 0.2 0.7 9.7 0.0 2.1 2 0 0 2 2 2 0 Outer membrane efflux protein Rsm22 PF09243.10 EDK41411.2 - 3.7e-23 82.2 3.3 9.7e-08 31.6 0.0 4.3 4 0 0 4 4 4 4 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_12 PF08242.12 EDK41411.2 - 0.017 15.8 0.0 0.26 12.0 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain FIN1 PF17300.2 EDK41411.2 - 0.17 11.4 16.0 1.2 8.6 4.2 3.2 3 0 0 3 3 3 0 Filaments in between nuclei protein-1 Trypan_PARP PF05887.11 EDK41411.2 - 0.99 9.4 18.4 0.062 13.3 6.1 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) EzrA PF06160.12 EDK41412.2 - 0.0066 14.7 5.7 0.0098 14.1 1.5 2.1 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA KxDL PF10241.9 EDK41412.2 - 1.6 9.1 5.4 5.6 7.3 0.8 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein Mito_carr PF00153.27 EDK41413.2 - 7.9e-60 198.8 0.3 9.5e-23 79.9 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Raptor_N PF14538.6 EDK41414.2 - 1.3e-66 223.1 0.0 2.4e-66 222.2 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EDK41414.2 - 1e-07 32.5 7.6 1.1 10.2 0.1 7.1 8 0 0 8 8 8 3 WD domain, G-beta repeat HEAT PF02985.22 EDK41414.2 - 1.5e-06 28.0 0.1 0.14 12.5 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EDK41414.2 - 0.00015 21.8 0.0 0.29 11.2 0.0 3.4 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 PF12894.7 EDK41414.2 - 0.0016 18.7 0.0 7.6 6.9 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 EDK41414.2 - 0.021 15.2 0.0 1.1 9.7 0.0 3.0 2 1 1 3 3 3 0 HEAT repeats CDO_I PF05995.12 EDK41415.2 - 5.1e-38 130.0 0.0 6.7e-38 129.6 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EDK41415.2 - 0.037 13.5 0.9 0.35 10.3 0.9 2.0 1 1 0 1 1 1 0 PCO_ADO SLAC1 PF03595.17 EDK41416.2 - 1.2e-69 235.1 44.6 1.4e-69 234.8 44.6 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF2193 PF09959.9 EDK41416.2 - 0.19 10.1 0.4 6.6 5.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2193) Trs65 PF12735.7 EDK41417.2 - 4.5e-66 223.4 1.3 7.8e-66 222.6 1.3 1.4 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Laminin_EGF PF00053.24 EDK41418.2 - 0.067 13.3 0.2 0.11 12.7 0.2 1.2 1 0 0 1 1 1 0 Laminin EGF domain DUF4451 PF14616.6 EDK41419.2 - 3.1e-29 101.7 1.0 3.1e-29 101.7 1.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) zf-Di19 PF05605.12 EDK41419.2 - 0.081 13.2 7.6 5.8 7.3 0.1 3.0 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding HGTP_anticodon PF03129.20 EDK41420.2 - 3.9e-21 75.0 0.2 1.3e-20 73.3 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDK41420.2 - 1.6e-07 31.5 0.1 4.7e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) FMO-like PF00743.19 EDK41421.2 - 7e-16 57.7 2.9 1.6e-14 53.3 2.9 2.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDK41421.2 - 6.7e-10 38.7 0.3 1.1e-08 34.7 0.3 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK41421.2 - 1.8e-09 37.6 0.0 5.5e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDK41421.2 - 3.5e-09 36.3 0.0 1.9e-05 24.0 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDK41421.2 - 1.3e-08 34.4 0.1 4.6e-06 26.0 0.1 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EDK41421.2 - 0.00015 21.1 0.0 0.0024 17.1 0.0 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EDK41421.2 - 0.0003 20.5 0.0 0.0044 16.6 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK41421.2 - 0.0028 16.8 0.0 0.0058 15.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EDK41421.2 - 0.0031 17.5 0.0 0.2 11.7 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EDK41421.2 - 0.037 14.1 0.0 9.4 6.3 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EDK41421.2 - 0.1 11.3 0.1 0.18 10.5 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 EDK41421.2 - 0.11 11.5 0.0 0.97 8.4 0.0 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EDK41421.2 - 0.19 11.1 0.0 0.4 10.0 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDK41422.2 - 7.1e-11 41.9 0.0 4.4e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EDK41422.2 - 4.4e-10 38.6 0.1 9.3e-06 24.3 0.0 3.1 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EDK41422.2 - 2.3e-08 34.1 0.0 7.6e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EDK41422.2 - 3.3e-07 29.8 0.2 9.4e-06 25.0 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDK41422.2 - 4.1e-07 29.6 0.7 0.0004 19.7 0.9 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDK41422.2 - 3.3e-05 23.9 0.0 0.025 14.6 0.0 3.8 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 EDK41422.2 - 3.6e-05 23.5 0.0 0.00049 19.8 0.0 2.6 1 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EDK41422.2 - 0.0024 17.2 0.2 0.1 11.8 0.0 2.9 3 0 0 3 3 3 1 Thi4 family FAD_binding_2 PF00890.24 EDK41422.2 - 0.0096 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EDK41422.2 - 0.017 14.2 0.1 2.3 7.2 0.1 2.5 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EDK41422.2 - 0.036 13.4 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDK41422.2 - 0.042 14.4 0.0 2.4 8.8 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Spermine_synth PF01564.17 EDK41422.2 - 0.086 12.2 0.0 2.2 7.7 0.0 2.6 3 0 0 3 3 3 0 Spermine/spermidine synthase domain ABA_GPCR PF12430.8 EDK41423.2 - 4.7e-50 169.8 6.7 4.7e-50 169.8 6.7 2.0 2 1 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EDK41423.2 - 6.2e-15 55.0 0.6 6.2e-15 55.0 0.6 2.5 3 0 0 3 3 3 1 The Golgi pH Regulator (GPHR) Family N-terminal DUF2721 PF11026.8 EDK41423.2 - 1.4 8.8 9.1 0.25 11.2 2.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Mhr1 PF12829.7 EDK41424.2 - 7.6e-23 80.4 0.5 1.6e-22 79.4 0.5 1.6 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Caldesmon PF02029.15 EDK41424.2 - 8.7 5.0 9.3 5.7 5.6 1.5 2.3 2 1 0 2 2 2 0 Caldesmon Fungal_trans PF04082.18 EDK41425.2 - 9.1e-10 38.0 9.6 2.4e-09 36.6 9.6 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK41425.2 - 8.2e-07 29.1 15.2 1.5e-06 28.2 15.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TINF2_N PF14973.6 EDK41425.2 - 0.11 12.8 0.0 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus AAA PF00004.29 EDK41426.2 - 3.2e-40 137.6 0.0 5.8e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK41426.2 - 1.3e-07 31.3 0.0 4.1e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EDK41426.2 - 6e-05 23.1 0.0 0.0002 21.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK41426.2 - 6.1e-05 23.3 0.0 0.0027 18.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EDK41426.2 - 0.00017 22.0 0.2 0.0041 17.5 0.0 2.4 2 1 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 EDK41426.2 - 0.00039 20.6 0.0 0.00075 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDK41426.2 - 0.00055 19.2 0.0 0.001 18.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EDK41426.2 - 0.0045 16.7 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDK41426.2 - 0.012 15.9 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDK41426.2 - 0.017 14.7 0.0 0.047 13.2 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EDK41426.2 - 0.024 14.8 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDK41426.2 - 0.031 14.8 0.0 0.074 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDK41426.2 - 0.032 14.0 0.1 0.085 12.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDK41426.2 - 0.036 14.4 0.0 0.082 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EDK41426.2 - 0.039 13.3 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 EDK41426.2 - 0.041 13.8 0.0 5.2 6.9 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 EDK41426.2 - 0.046 12.9 0.0 0.077 12.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 EDK41426.2 - 0.047 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EDK41426.2 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF4168 PF13767.6 EDK41426.2 - 0.14 13.4 0.1 0.44 11.8 0.1 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4168) Sigma54_activat PF00158.26 EDK41426.2 - 0.16 11.7 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_pol_Rbc25 PF08292.12 EDK41428.2 - 3e-44 150.4 2.4 7.6e-44 149.1 2.4 1.6 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EDK41428.2 - 3.1e-18 65.9 0.0 5.2e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EDK41428.2 - 0.029 14.7 0.0 0.065 13.6 0.0 1.6 1 1 0 1 1 1 0 S1 RNA binding domain RRM_1 PF00076.22 EDK41429.1 - 7.4e-20 70.5 0.0 1.1e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMEM223 PF14640.6 EDK41430.2 - 0.00011 22.5 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 223 DctQ PF04290.12 EDK41430.2 - 0.078 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component Iron_permease PF04120.12 EDK41432.2 - 0.23 11.2 1.1 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Low affinity iron permease CUE PF02845.16 EDK41433.2 - 2.2e-10 40.0 0.0 3.6e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain Pneumo_att_G PF05539.11 EDK41433.2 - 8.1 5.9 12.3 15 5.1 12.3 1.4 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SSI PF00720.17 EDK41434.2 - 0.091 12.7 0.2 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 Subtilisin inhibitor-like GATA PF00320.27 EDK41435.2 - 6.8e-13 48.0 4.1 1.4e-12 47.0 3.1 2.0 2 0 0 2 2 2 1 GATA zinc finger Hydrolase_6 PF13344.6 EDK41436.2 - 4.2e-24 84.6 0.0 7e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDK41436.2 - 0.079 13.2 0.1 16 5.7 0.1 2.5 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase TP_methylase PF00590.20 EDK41437.2 - 9.7e-44 149.8 0.1 2.3e-43 148.6 0.0 1.7 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 EDK41437.2 - 7.6e-13 48.8 0.0 1.6e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 EDK41437.2 - 8.5e-08 31.5 0.0 1.5e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 EDK41437.2 - 1.1e-05 24.9 0.0 0.14 11.8 0.0 3.3 3 0 0 3 3 3 2 Sirohaem biosynthesis protein C-terminal Nro1 PF12753.7 EDK41438.2 - 2.4e-169 563.6 26.3 2.7e-169 563.5 26.3 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 TPR_19 PF14559.6 EDK41438.2 - 0.002 18.6 0.0 0.002 18.6 0.0 4.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDK41438.2 - 0.0035 18.0 1.1 8.9 7.4 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat PI3K_1B_p101 PF10486.9 EDK41438.2 - 0.0096 13.8 2.2 0.013 13.3 2.2 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TPR_12 PF13424.6 EDK41438.2 - 0.025 14.8 0.5 1.4 9.2 0.0 3.8 3 2 0 3 3 3 0 Tetratricopeptide repeat FAM163 PF15069.6 EDK41438.2 - 0.22 12.0 0.5 0.53 10.7 0.5 1.6 1 0 0 1 1 1 0 FAM163 family TPR_1 PF00515.28 EDK41438.2 - 0.52 10.2 5.7 23 5.0 0.8 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat Cnd1 PF12717.7 EDK41438.2 - 1.1 9.3 5.9 1.2 9.2 0.2 3.3 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 zf-AN1 PF01428.16 EDK41439.2 - 1.7e-10 40.9 6.5 4e-10 39.7 6.5 1.7 1 0 0 1 1 1 1 AN1-like Zinc finger ubiquitin PF00240.23 EDK41439.2 - 0.00058 19.6 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Transp_Tc5_C PF04236.15 EDK41439.2 - 0.049 14.0 1.2 0.049 14.0 1.2 2.1 3 0 0 3 3 3 0 Tc5 transposase C-terminal domain DUF2080 PF09853.9 EDK41439.2 - 0.26 11.1 0.8 16 5.3 0.0 2.5 2 0 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) Acyltransferase PF01553.21 EDK41440.2 - 2e-09 37.2 0.0 2.3e-08 33.8 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase TRAPP PF04051.16 EDK41441.1 - 2.6e-25 88.9 0.0 2.9e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FA_hydroxylase PF04116.13 EDK41442.1 - 5.8e-24 84.9 7.5 5.8e-24 84.9 7.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Wzy_C_2 PF11846.8 EDK41442.1 - 0.0025 17.7 0.2 0.0078 16.2 0.0 1.8 2 0 0 2 2 2 1 Virulence factor membrane-bound polymerase, C-terminal Tenui_N PF05733.11 EDK41442.1 - 0.098 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Tenuivirus/Phlebovirus nucleocapsid protein Gate PF07670.14 EDK41443.1 - 0.32 11.3 9.7 2.3 8.5 1.0 2.8 1 1 1 2 2 2 0 Nucleoside recognition Methyltransf_11 PF08241.12 EDK41444.2 - 3.5e-18 66.0 0.0 6.6e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK41444.2 - 3.5e-17 62.9 0.0 8.6e-17 61.6 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK41444.2 - 2.7e-10 40.9 0.0 5.3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK41444.2 - 6.9e-10 38.9 0.0 1.1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDK41444.2 - 5.8e-07 29.1 0.0 1.1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EDK41444.2 - 4.1e-06 26.7 0.0 6.7e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDK41444.2 - 0.00021 20.9 0.0 0.00049 19.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 EDK41444.2 - 0.0011 18.1 0.0 0.0017 17.4 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase CMAS PF02353.20 EDK41444.2 - 0.0062 15.9 0.0 0.032 13.5 0.0 2.0 1 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase DREV PF05219.12 EDK41444.2 - 0.0092 15.1 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_PK PF05891.12 EDK41444.2 - 0.028 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.6 EDK41444.2 - 0.031 14.3 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EDK41444.2 - 0.04 13.3 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EDK41444.2 - 0.065 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase HUN PF08729.10 EDK41444.2 - 0.08 12.9 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 HPC2 and ubinuclein domain Methyltransf_4 PF02390.17 EDK41444.2 - 0.1 12.1 0.0 0.54 9.7 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Pirin PF02678.16 EDK41445.1 - 2.3e-27 95.1 0.4 3.9e-27 94.4 0.4 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EDK41445.1 - 3.1e-22 78.9 0.0 5.6e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EDK41445.1 - 0.0001 21.9 0.6 0.17 11.6 0.0 2.4 2 0 0 2 2 2 2 Cupin domain CDC27 PF09507.10 EDK41446.2 - 6.4e-23 81.8 24.0 6.2e-21 75.3 12.3 2.2 1 1 1 2 2 2 2 DNA polymerase subunit Cdc27 RPA_interact_M PF14767.6 EDK41446.2 - 0.023 15.3 2.6 0.49 11.0 1.0 2.4 2 0 0 2 2 2 0 Replication protein A interacting middle RRP7 PF12923.7 EDK41446.2 - 0.026 14.6 8.0 0.1 12.7 0.2 2.8 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain MukB PF04310.12 EDK41447.2 - 0.003 17.4 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 MukB N-terminal TSC22 PF01166.18 EDK41447.2 - 0.074 13.4 0.5 2.3 8.6 0.3 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family FA_desaturase PF00487.24 EDK41450.2 - 0.026 14.4 0.2 0.035 13.9 0.2 1.1 1 0 0 1 1 1 0 Fatty acid desaturase zf-C3HC4_3 PF13920.6 EDK41451.2 - 0.084 12.8 8.0 0.059 13.2 4.0 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ADH_N PF08240.12 EDK41452.2 - 0.071 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF1727 PF08353.10 EDK41452.2 - 0.092 12.7 0.5 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1727) Peptidase_M20 PF01546.28 EDK41453.2 - 1.4e-23 83.7 0.0 2.2e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDK41453.2 - 5.1e-10 39.2 0.0 8.9e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 EDK41453.2 - 3.7e-06 27.6 3.3 1.1 10.3 0.0 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK41453.2 - 0.00073 19.8 0.0 0.014 15.7 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M28 PF04389.17 EDK41453.2 - 0.018 14.8 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M28 FA_synthesis PF02504.15 EDK41453.2 - 0.23 10.5 0.1 0.52 9.3 0.0 1.5 2 0 0 2 2 2 0 Fatty acid synthesis protein SPX PF03105.19 EDK41454.2 - 1.3e-51 176.8 15.9 1.6e-51 176.4 15.9 1.1 1 0 0 1 1 1 1 SPX domain FoP_duplication PF13865.6 EDK41454.2 - 0.38 11.3 4.6 0.78 10.3 4.6 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 CitMHS PF03600.16 EDK41455.2 - 5.7e-20 71.7 56.2 5.9e-15 55.2 28.8 1.8 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 EDK41455.2 - 9e-16 58.0 30.2 1.1e-14 54.4 30.2 1.9 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region DUF2304 PF10066.9 EDK41455.2 - 1.1 9.5 10.8 7.4 6.8 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) DUF373 PF04123.13 EDK41455.2 - 3.9 6.8 16.7 1.8 7.9 10.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Sigma70_r1_1 PF03979.14 EDK41456.2 - 0.0015 18.5 0.9 3 8.0 0.1 3.2 3 0 0 3 3 3 2 Sigma-70 factor, region 1.1 Elongin_A PF06881.11 EDK41456.2 - 0.027 15.0 0.0 0.054 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DotA PF11388.8 EDK41456.2 - 0.081 13.1 1.1 0.17 12.1 0.1 2.0 2 0 0 2 2 2 0 Phagosome trafficking protein DotA AI-2E_transport PF01594.16 EDK41456.2 - 0.49 9.5 2.8 0.26 10.4 0.4 1.8 2 0 0 2 2 2 0 AI-2E family transporter MotA_activ PF09114.10 EDK41457.2 - 0.21 11.8 1.5 0.51 10.5 0.1 2.4 2 1 0 2 2 2 0 Transcription factor MotA, activation domain PI3_PI4_kinase PF00454.27 EDK41458.2 - 1.4e-49 169.2 0.0 2e-49 168.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ApbA_C PF08546.11 EDK41459.2 - 2.3e-29 102.1 0.0 4.9e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDK41459.2 - 5e-25 87.9 0.0 6.9e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EDK41459.2 - 0.002 18.7 0.2 0.0047 17.4 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDK41459.2 - 0.11 11.7 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Phos_pyr_kin PF08543.12 EDK41460.1 - 1.3e-14 54.2 0.0 1.8e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EDK41460.1 - 4.8e-05 22.8 0.0 8.8e-05 21.9 0.0 1.4 1 1 0 1 1 1 1 pfkB family carbohydrate kinase V-set_CD47 PF08204.11 EDK41460.1 - 0.098 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain TIG PF01833.24 EDK41461.2 - 2.5e-10 40.3 2.0 7.8e-10 38.7 0.4 2.6 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 EDK41461.2 - 2e-08 34.7 0.0 4.8e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDK41461.2 - 2.4e-07 31.2 0.1 8.4e-07 29.4 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EDK41461.2 - 2.3e-05 24.6 0.0 0.0068 16.8 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 EDK41461.2 - 4.3e-05 23.6 0.0 0.1 13.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EDK41461.2 - 0.00012 22.3 0.0 0.00039 20.7 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF4838 PF16126.5 EDK41461.2 - 0.03 13.7 0.0 0.062 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) RHD_dimer PF16179.5 EDK41461.2 - 0.086 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Rel homology dimerisation domain HEM4 PF02602.15 EDK41462.2 - 1.8e-47 161.7 0.0 2e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD AMP-binding PF00501.28 EDK41463.2 - 5.8e-87 292.0 0.0 7e-87 291.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDK41463.2 - 7.3e-24 84.6 0.6 1.3e-22 80.6 0.4 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EDK41463.2 - 1.4e-16 60.1 0.5 3.3e-16 59.0 0.5 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus OPA3 PF07047.12 EDK41464.2 - 9.5e-48 161.1 0.6 9.5e-48 161.1 0.6 1.5 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) DUF5320 PF17253.2 EDK41464.2 - 0.023 15.8 0.0 0.043 14.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Histone PF00125.24 EDK41465.1 - 8e-17 61.8 0.0 1.1e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EDK41465.1 - 9.8e-14 50.8 0.7 1.6e-13 50.1 0.7 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EDK41465.1 - 0.00061 20.0 0.0 0.00092 19.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NPR2 PF06218.11 EDK41466.2 - 7.6e-198 657.7 1.6 1.2e-197 657.0 0.6 1.7 2 0 0 2 2 2 1 Nitrogen permease regulator 2 Cpn60_TCP1 PF00118.24 EDK41467.2 - 1.5e-82 277.8 10.8 4e-82 276.4 10.8 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rrf2 PF02082.20 EDK41467.2 - 0.056 13.8 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator DUF1542 PF07564.11 EDK41467.2 - 0.89 9.7 8.1 5.2 7.3 2.1 2.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) RNA_pol_I_TF PF04090.12 EDK41468.2 - 6.7e-73 244.4 0.2 1.3e-72 243.5 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor Heme_oxygenase PF01126.20 EDK41468.2 - 0.073 12.8 2.1 1 9.1 0.0 2.2 2 0 0 2 2 2 0 Heme oxygenase zf-rbx1 PF12678.7 EDK41469.2 - 9e-10 38.7 1.1 1.6e-09 37.9 1.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDK41469.2 - 6.3e-09 36.0 4.5 1.9e-08 34.5 4.5 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EDK41469.2 - 2.1e-05 24.3 2.1 0.00053 19.8 0.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDK41469.2 - 5.6e-05 22.9 1.4 0.00012 21.8 1.4 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDK41469.2 - 6.9e-05 22.6 2.0 0.00014 21.6 2.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDK41469.2 - 0.00035 20.3 2.1 0.00035 20.3 2.1 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDK41469.2 - 0.00071 19.1 0.5 0.0014 18.2 0.5 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EDK41469.2 - 0.00088 19.2 2.4 0.0018 18.2 2.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EDK41469.2 - 0.0011 19.0 2.0 0.0035 17.3 2.0 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EDK41469.2 - 0.0014 18.5 1.6 0.0033 17.3 1.7 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EDK41469.2 - 0.033 14.3 0.6 0.086 13.0 0.6 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EDK41469.2 - 0.16 12.3 0.8 0.28 11.5 0.8 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 EDK41469.2 - 0.19 11.9 3.0 1 9.6 3.0 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.14 EDK41469.2 - 0.24 11.1 1.7 0.81 9.4 0.6 2.2 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.6 EDK41469.2 - 0.49 10.2 2.1 1 9.2 0.8 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Kinesin PF00225.23 EDK41470.2 - 3.9e-102 341.6 4.0 3.9e-102 341.6 4.0 2.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDK41470.2 - 8e-21 74.5 2.0 9.3e-20 71.1 0.1 3.0 2 0 0 2 2 2 1 Microtubule binding DUF3828 PF12883.7 EDK41470.2 - 0.03 14.7 0.2 0.12 12.8 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) DUF4806 PF16064.5 EDK41470.2 - 0.67 10.3 5.1 1.6 9.1 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) DUF2316 PF10078.9 EDK41470.2 - 2 8.7 6.1 1.3 9.3 0.4 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) dsDNA_bind PF01984.20 EDK41471.2 - 5e-27 94.4 1.3 6.6e-27 94.0 1.3 1.2 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Ras PF00071.22 EDK41472.2 - 8.9e-46 155.4 0.2 1e-45 155.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDK41472.2 - 6.8e-27 94.1 0.1 1.2e-26 93.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDK41472.2 - 3.2e-08 33.2 0.3 3.8e-08 33.0 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDK41472.2 - 0.00025 20.7 0.1 0.00026 20.6 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDK41472.2 - 0.11 11.9 0.2 0.13 11.5 0.2 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region CIDE-N PF02017.15 EDK41472.2 - 0.11 12.5 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 CIDE-N domain zf-C2H2 PF00096.26 EDK41473.2 - 1.3e-12 47.4 13.0 8.5e-06 25.9 2.1 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDK41473.2 - 3.6e-09 36.6 4.9 3.6e-09 36.6 4.9 3.5 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDK41473.2 - 9.2e-08 32.3 11.4 8.9e-05 23.0 3.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDK41473.2 - 8.3e-05 22.5 1.6 8.3e-05 22.5 1.6 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 EDK41473.2 - 0.0014 18.9 3.7 0.59 10.6 0.6 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EDK41473.2 - 0.0038 17.5 1.1 0.0038 17.5 1.1 2.1 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EDK41473.2 - 0.0096 16.2 3.0 0.033 14.5 0.4 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 EDK41473.2 - 0.011 15.6 1.5 0.25 11.3 0.8 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Ogr_Delta PF04606.12 EDK41473.2 - 0.014 15.4 0.3 0.9 9.6 0.0 2.5 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf_C2H2_ZHX PF18387.1 EDK41473.2 - 0.054 13.1 6.0 0.53 10.0 0.8 2.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain OrsD PF12013.8 EDK41473.2 - 0.066 13.7 2.3 11 6.5 0.1 2.8 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 EDK41473.2 - 0.079 12.7 9.1 1.2 9.0 0.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 EDK41473.2 - 0.48 10.7 8.3 0.24 11.7 2.9 2.4 2 0 0 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EDK41473.2 - 0.77 10.4 4.2 14 6.4 0.1 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain GAGA PF09237.11 EDK41473.2 - 2.7 7.9 6.3 0.98 9.3 1.9 2.4 2 1 1 3 3 3 0 GAGA factor MFS_1 PF07690.16 EDK41474.2 - 1.4e-30 106.5 27.6 1.4e-30 106.5 27.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Cullin PF00888.22 EDK41475.2 - 0.038 12.6 1.8 0.054 12.1 1.5 1.4 1 1 1 2 2 2 0 Cullin family RPW8 PF05659.11 EDK41475.2 - 0.095 12.4 0.0 0.095 12.4 0.0 2.2 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Metallophos PF00149.28 EDK41476.2 - 6.4e-35 121.5 0.0 1.2e-34 120.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDK41476.2 - 9e-19 67.7 0.7 2e-18 66.6 0.7 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Methyltransf_23 PF13489.6 EDK41476.2 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.25 EDK41477.2 - 1.9e-07 31.3 0.0 3.6e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDK41477.2 - 1.3e-06 28.8 0.0 2.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK41477.2 - 4.5e-05 23.4 0.0 7.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDK41477.2 - 8.5e-05 22.5 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EDK41477.2 - 0.00018 21.6 0.0 0.00071 19.6 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EDK41477.2 - 0.0044 16.6 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase Pfk_N PF18468.1 EDK41477.2 - 0.065 13.7 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast Acetyltransf_CG PF14542.6 EDK41477.2 - 0.065 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Methyltransf_28 PF02636.17 EDK41478.2 - 2.3e-83 279.9 0.0 3.1e-83 279.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CdvA PF18822.1 EDK41478.2 - 0.052 13.4 0.7 0.11 12.3 0.7 1.6 1 0 0 1 1 1 0 CdvA-like coiled-coil domain LCM PF04072.14 EDK41479.2 - 1.1e-25 90.7 0.0 1.4e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase ArdA PF07275.11 EDK41479.2 - 0.045 14.3 0.0 0.14 12.7 0.0 1.9 1 0 0 1 1 1 0 Antirestriction protein (ArdA) TTRAP PF14203.6 EDK41479.2 - 0.088 12.8 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein Methyltransf_11 PF08241.12 EDK41480.2 - 9.4e-12 45.4 0.0 1.5e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK41480.2 - 9.5e-10 39.1 0.0 1.5e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK41480.2 - 4.2e-08 33.1 0.0 5.6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDK41480.2 - 1.3e-06 28.3 0.0 1.7e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK41480.2 - 0.00011 22.8 0.0 0.0002 22.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDK41480.2 - 0.0034 16.3 0.0 0.005 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TAFII28 PF04719.14 EDK41482.2 - 1.1e-26 92.7 0.0 2.5e-26 91.6 0.0 1.6 1 1 0 1 1 1 1 hTAFII28-like protein conserved region Catalase PF00199.19 EDK41483.2 - 5.2e-170 565.7 0.0 6.6e-170 565.3 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDK41483.2 - 4e-10 39.7 0.0 1.7e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 Catalase-related immune-responsive DUF2004 PF09406.10 EDK41484.2 - 0.019 15.3 0.1 0.044 14.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) SET PF00856.28 EDK41485.2 - 2.3e-14 54.1 0.0 4.5e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 SET domain HTH_21 PF13276.6 EDK41485.2 - 0.00034 20.7 0.0 0.00066 19.8 0.0 1.5 1 0 0 1 1 1 1 HTH-like domain DUF2852 PF11014.8 EDK41485.2 - 0.035 14.2 0.4 0.035 14.2 0.4 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2852) SAF PF08666.12 EDK41485.2 - 0.1 13.3 0.0 3 8.6 0.0 2.4 2 0 0 2 2 2 0 SAF domain 5-FTHF_cyc-lig PF01812.20 EDK41486.2 - 3.2e-39 134.7 0.0 3.7e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Cyt-b5 PF00173.28 EDK41487.2 - 3.2e-22 78.4 0.0 4.3e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UCH PF00443.29 EDK41489.2 - 2e-05 24.2 3.8 2.4e-05 24.0 3.8 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GREB1 PF15782.5 EDK41489.2 - 2.9 4.9 9.0 3.3 4.7 9.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer UCH PF00443.29 EDK41490.2 - 2.5e-12 46.9 1.5 2.5e-12 46.9 1.5 1.9 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SPX PF03105.19 EDK41491.2 - 1.5e-46 160.1 6.3 1.9e-30 107.1 4.1 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EDK41491.2 - 2.6e-27 96.0 39.4 3.8e-27 95.5 39.4 1.3 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EDK41491.2 - 1.2e-26 93.7 65.7 5.5e-24 84.9 40.5 2.0 1 1 1 2 2 2 2 Citrate transporter PIG-P PF08510.12 EDK41491.2 - 0.0078 16.1 2.9 0.014 15.3 0.1 2.9 2 1 0 2 2 2 1 PIG-P TFIIA_gamma_N PF02268.16 EDK41491.2 - 0.031 14.3 1.1 0.097 12.7 0.0 2.4 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain SURF2 PF05477.11 EDK41491.2 - 4.9 6.8 5.2 8.2 6.0 5.2 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) UPF0121 PF03661.13 EDK41492.2 - 4.1e-13 49.3 12.6 6.3e-13 48.7 12.6 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) NnrU PF07298.11 EDK41492.2 - 0.039 13.4 1.9 0.077 12.5 0.2 2.2 3 0 0 3 3 3 0 NnrU protein TMEM208_SND2 PF05620.11 EDK41493.2 - 3.2e-13 49.8 0.0 3.7e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 BolA PF01722.18 EDK41494.2 - 4.1e-32 110.3 1.1 4.1e-32 110.3 1.1 1.6 2 0 0 2 2 2 1 BolA-like protein Myosin_head PF00063.21 EDK41495.2 - 1.6e-277 922.3 6.3 1.6e-277 922.3 6.3 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 EDK41495.2 - 7.8e-25 87.2 0.2 7.8e-25 87.2 0.2 2.8 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 EDK41495.2 - 2.5e-17 60.9 22.0 6.9e-05 22.3 0.1 6.5 6 0 0 6 6 6 4 IQ calmodulin-binding motif Myosin_N PF02736.19 EDK41495.2 - 0.0001 22.1 0.3 0.00039 20.2 0.3 2.1 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EDK41495.2 - 0.0048 17.2 0.0 0.036 14.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDK41495.2 - 0.022 15.2 4.0 0.14 12.6 0.0 3.0 2 0 0 2 2 2 0 ABC transporter Nup54_57_C PF18570.1 EDK41495.2 - 0.1 12.2 0.3 0.34 10.5 0.3 2.0 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain T6PP_N PF18572.1 EDK41495.2 - 0.13 12.1 20.7 4.4 7.2 0.0 4.6 2 1 1 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain AAA_16 PF13191.6 EDK41495.2 - 0.21 11.9 3.3 0.25 11.7 0.0 2.7 2 1 0 2 2 1 0 AAA ATPase domain BRE1 PF08647.11 EDK41495.2 - 2 8.6 29.2 1.4 9.1 10.3 3.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase UPF0242 PF06785.11 EDK41495.2 - 4.7 7.3 25.6 19 5.3 25.6 2.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 EDK41495.2 - 6.6 7.3 33.0 17 5.9 28.4 3.4 1 1 1 2 2 2 0 Apg6 coiled-coil region FMN_dh PF01070.18 EDK41496.2 - 2.8e-114 381.8 0.1 3.5e-114 381.5 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDK41496.2 - 1.3e-25 89.3 0.5 3.4e-25 88.0 0.3 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDK41496.2 - 7e-07 28.7 0.0 1.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDK41496.2 - 0.00052 19.1 0.0 0.00097 18.2 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EDK41496.2 - 0.073 12.5 0.0 0.49 9.8 0.0 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein Copper-fist PF00649.18 EDK41497.2 - 1e-20 72.9 1.1 1e-20 72.9 1.1 2.5 1 1 1 2 2 2 1 Copper fist DNA binding domain Ran-binding PF05508.11 EDK41498.2 - 1.3e-97 326.6 1.5 1.7e-97 326.2 1.5 1.1 1 0 0 1 1 1 1 RanGTP-binding protein RNA_pol_Rpo13 PF12136.8 EDK41498.2 - 0.019 14.9 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain SNF2_N PF00176.23 EDK41499.2 - 5.4e-55 186.5 0.0 8.6e-55 185.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EDK41499.2 - 1e-45 156.1 0.4 1.9e-45 155.3 0.4 1.4 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.31 EDK41499.2 - 1.8e-16 60.4 0.0 3.2e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41499.2 - 1.8e-06 28.1 0.0 4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDK41499.2 - 6.3e-06 25.6 0.0 3.9e-05 23.0 0.0 2.2 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 FAD_binding_2 PF00890.24 EDK41501.2 - 1.2e-82 278.3 0.0 1.6e-82 277.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EDK41501.2 - 5.6e-22 77.7 0.0 1.7e-20 72.9 0.0 2.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EDK41501.2 - 1.4e-13 51.2 0.0 2.2e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EDK41501.2 - 7.4e-08 32.2 0.1 1.6e-07 31.1 0.1 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDK41501.2 - 1.3e-07 31.1 0.3 3.6e-06 26.4 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDK41501.2 - 3.6e-07 30.3 0.6 1.6e-06 28.2 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDK41501.2 - 9.2e-06 24.6 2.9 0.00073 18.4 0.1 3.0 3 1 0 3 3 3 2 HI0933-like protein GIDA PF01134.22 EDK41501.2 - 2.4e-05 23.6 0.4 0.00027 20.2 0.1 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EDK41501.2 - 0.00071 18.9 0.1 0.0014 18.0 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EDK41501.2 - 0.002 17.4 0.3 0.0035 16.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Streptin-Immun PF11083.8 EDK41501.2 - 0.0029 18.0 0.1 0.0063 16.9 0.1 1.5 1 0 0 1 1 1 1 Lantibiotic streptin immunity protein HTH_11 PF08279.12 EDK41501.2 - 0.03 14.3 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 HTH domain Pyr_redox_3 PF13738.6 EDK41501.2 - 0.03 13.6 0.1 0.32 10.2 0.0 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDK41501.2 - 0.04 13.2 0.1 0.72 9.0 0.1 2.4 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 EDK41501.2 - 0.097 11.7 0.2 0.16 11.0 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Skp1 PF01466.19 EDK41501.2 - 0.26 11.4 1.1 0.47 10.6 0.4 1.8 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Actin PF00022.19 EDK41502.1 - 1.9e-142 474.7 0.0 6.1e-142 473.0 0.0 1.6 1 1 0 1 1 1 1 Actin Synaptobrevin PF00957.21 EDK41503.1 - 1.6e-27 95.1 1.5 1.8e-27 95.0 1.5 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF3671 PF12420.8 EDK41503.1 - 0.45 10.6 3.6 0.48 10.5 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function GCV_H PF01597.19 EDK41504.1 - 3.1e-23 82.0 0.2 4.3e-23 81.5 0.2 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein LicD PF04991.13 EDK41505.2 - 1.7e-18 67.6 8.6 2.2e-14 54.2 0.5 2.8 2 1 1 3 3 3 2 LicD family HSP70 PF00012.20 EDK41506.1 - 4.4e-68 229.9 0.1 4.8e-68 229.8 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 EDK41506.1 - 9.2e-05 22.2 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF1464 PF07318.12 EDK41506.1 - 0.015 14.5 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) HSP70 PF00012.20 EDK41507.2 - 1.7e-56 191.7 1.9 1.8e-56 191.6 1.9 1.0 1 0 0 1 1 1 1 Hsp70 protein TBCA PF02970.16 EDK41507.2 - 0.044 14.1 10.1 0.068 13.5 10.1 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A TGT PF01702.18 EDK41507.2 - 0.098 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase Cnd1_N PF12922.7 EDK41507.2 - 2.5 7.9 6.1 2.1 8.2 5.0 1.4 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term Na_Ca_ex PF01699.24 EDK41508.2 - 6.4e-39 133.3 44.4 7.6e-26 90.9 17.7 3.7 4 0 0 4 4 4 2 Sodium/calcium exchanger protein HSM3_C PF18794.1 EDK41511.2 - 1.1e-17 64.2 0.0 1.9e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain Med16 PF11635.8 EDK41512.2 - 3.3e-206 686.7 1.3 4e-206 686.4 1.3 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 SHMT PF00464.19 EDK41513.2 - 6.6e-206 683.6 0.1 7.6e-206 683.3 0.1 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EDK41513.2 - 9.9e-07 28.2 0.0 1.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDK41513.2 - 0.013 14.8 0.0 0.028 13.7 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDK41513.2 - 0.022 14.1 0.1 0.047 13.0 0.1 1.4 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pkinase PF00069.25 EDK41514.2 - 3.9e-43 147.7 0.0 4.9e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41514.2 - 6.8e-21 74.7 0.0 9.3e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDK41514.2 - 9.2e-07 28.4 0.0 1.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDK41514.2 - 5e-06 26.6 0.0 7.6e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDK41514.2 - 5.8e-05 22.6 0.0 9e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Amidinotransf PF02274.17 EDK41514.2 - 0.0099 15.0 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 1 Amidinotransferase Ral PF11058.8 EDK41514.2 - 0.14 11.8 0.0 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Antirestriction protein Ral DUF5427 PF10310.9 EDK41515.2 - 7.5e-102 341.7 9.2 1.7e-101 340.5 9.2 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5427) FAM76 PF16046.5 EDK41515.2 - 0.62 9.4 8.3 0.7 9.2 0.1 2.2 2 0 0 2 2 2 0 FAM76 protein DUF1687 PF07955.11 EDK41516.2 - 1.2e-08 35.5 0.0 2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) CN_hydrolase PF00795.22 EDK41517.1 - 9.2e-48 162.8 0.0 5.1e-47 160.4 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase BCDHK_Adom3 PF10436.9 EDK41518.2 - 1.3e-66 223.4 0.0 2.2e-66 222.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDK41518.2 - 2.6e-11 44.0 0.0 5.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zinc_ribbon_10 PF10058.9 EDK41518.2 - 0.039 13.7 0.4 0.075 12.8 0.4 1.4 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Peroxin-13_N PF04088.13 EDK41519.2 - 5.4e-50 169.4 0.4 7.6e-50 169.0 0.4 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EDK41519.2 - 1.2e-08 34.4 0.0 2.6e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDK41519.2 - 1.4e-07 31.0 0.0 2.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK41519.2 - 2.1e-07 30.7 0.0 3.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EDK41519.2 - 0.0065 16.7 0.0 0.0065 16.7 0.0 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain Pex2_Pex12 PF04757.14 EDK41519.2 - 0.1 12.2 0.2 0.44 10.1 0.2 1.8 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region MT0933_antitox PF14013.6 EDK41520.1 - 0.00016 21.9 39.4 0.016 15.5 6.5 4.4 1 1 3 4 4 4 2 MT0933-like antitoxin protein YtxH PF12732.7 EDK41520.1 - 0.028 15.0 28.5 0.63 10.6 7.8 3.7 1 1 2 3 3 3 0 YtxH-like protein DUF1192 PF06698.11 EDK41520.1 - 0.05 13.7 4.8 3.7 7.7 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) ISG65-75 PF11727.8 EDK41520.1 - 0.23 10.7 30.4 1.2 8.3 10.0 2.1 1 1 1 2 2 2 0 Invariant surface glycoprotein ApoC-I PF04691.12 EDK41520.1 - 0.36 10.8 8.6 3.5 7.6 0.4 3.1 2 1 1 3 3 3 0 Apolipoprotein C-I (ApoC-1) DUF948 PF06103.11 EDK41520.1 - 0.5 10.7 13.2 0.23 11.8 2.5 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) CheZ PF04344.13 EDK41520.1 - 0.79 9.6 9.0 21 5.0 8.9 2.1 1 1 0 1 1 1 0 Chemotaxis phosphatase, CheZ Mitofilin PF09731.9 EDK41520.1 - 0.89 8.3 24.1 1.1 8.1 24.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LEA_4 PF02987.16 EDK41520.1 - 1.1 9.3 41.3 0.062 13.4 13.6 4.2 3 2 0 4 4 4 0 Late embryogenesis abundant protein ApoLp-III PF07464.11 EDK41520.1 - 1.3 9.1 17.0 1.4 9.0 1.1 2.6 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) XRN_M PF17846.1 EDK41520.1 - 1.5 7.7 9.7 1.7 7.5 9.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF883 PF05957.13 EDK41520.1 - 2.1 9.0 18.6 4.4 8.0 5.3 3.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1674 PF07896.12 EDK41520.1 - 5.2 7.6 15.8 3.4 8.2 0.9 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF1674) GARP PF16731.5 EDK41520.1 - 6.7 6.4 35.4 1.7 8.3 2.6 3.1 1 1 2 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma GDA1_CD39 PF01150.17 EDK41521.2 - 1e-111 373.6 0.0 1.3e-111 373.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Serglycin PF04360.12 EDK41521.2 - 0.022 14.7 6.5 0.045 13.7 6.5 1.4 1 0 0 1 1 1 0 Serglycin NAD_kinase PF01513.21 EDK41522.2 - 5.8e-82 275.2 0.0 7.9e-82 274.7 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EDK41522.2 - 0.042 13.5 0.0 0.098 12.3 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain eIF-1a PF01176.19 EDK41522.2 - 0.058 13.2 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 DEAD PF00270.29 EDK41523.2 - 2e-49 167.7 0.0 5.8e-49 166.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK41523.2 - 1.7e-31 108.9 0.0 6.5e-31 106.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41523.2 - 0.0055 16.7 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDK41523.2 - 0.031 13.6 0.1 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Gly_transf_sug PF04488.15 EDK41524.2 - 9.4e-15 55.0 0.0 2.1e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Isochorismatase PF00857.20 EDK41525.2 - 8.8e-26 91.1 0.2 1.8e-25 90.1 0.2 1.6 1 1 0 1 1 1 1 Isochorismatase family Isy1 PF06246.12 EDK41526.2 - 6.2e-65 219.3 10.2 7.1e-65 219.1 10.2 1.0 1 0 0 1 1 1 1 Isy1-like splicing family PTPS PF01242.19 EDK41526.2 - 0.05 13.6 0.1 0.13 12.2 0.1 1.8 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase 2-oxoacid_dh PF00198.23 EDK41526.2 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) NUC153 PF08159.12 EDK41527.2 - 5.9e-14 51.6 0.6 1.1e-13 50.7 0.6 1.5 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EDK41527.2 - 6e-06 26.9 0.1 0.2 12.6 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK41527.2 - 0.086 13.1 0.0 0.56 10.5 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2065 PF09838.9 EDK41529.2 - 0.21 11.6 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) Lyase_1 PF00206.20 EDK41530.2 - 5e-102 341.5 0.0 9.2e-102 340.6 0.0 1.4 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 EDK41530.2 - 1.4e-22 80.2 0.0 3.8e-22 78.8 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal tRNA-synt_2 PF00152.20 EDK41531.2 - 1.1e-90 303.9 0.0 1.9e-90 303.1 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDK41531.2 - 5.4e-11 42.3 0.1 1.3e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.11 EDK41531.2 - 0.038 13.5 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain ProRS-C_1 PF09180.11 EDK41532.2 - 1.2e-25 89.5 0.5 3e-25 88.2 0.5 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EDK41532.2 - 8.9e-20 71.4 0.0 2e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDK41532.2 - 4.4e-19 68.4 0.0 1.9e-18 66.4 0.0 2.2 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.15 EDK41532.2 - 2.2e-09 37.5 0.5 4.4e-09 36.5 0.5 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Prok_Ub PF14454.6 EDK41532.2 - 0.076 12.7 0.0 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 Prokaryotic Ubiquitin PHP PF02811.19 EDK41533.2 - 9.1e-12 45.6 0.1 2.3e-11 44.3 0.1 1.6 1 1 0 1 1 1 1 PHP domain TAP42 PF04177.12 EDK41534.2 - 8.8e-82 274.8 5.5 9.9e-82 274.6 5.5 1.0 1 0 0 1 1 1 1 TAP42-like family DUF4999 PF16390.5 EDK41534.2 - 0.0032 17.7 1.6 0.0039 17.4 0.3 1.9 2 1 0 2 2 2 1 Domain of unknown function tRNA-synt_2 PF00152.20 EDK41535.2 - 1.7e-90 303.3 0.0 2e-90 303.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) zf-Tim10_DDP PF02953.15 EDK41536.1 - 6.6e-21 73.7 7.0 8.7e-21 73.3 7.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 EDK41536.1 - 0.011 16.0 0.0 0.11 12.8 0.1 1.9 1 1 1 2 2 2 0 Phasin protein Hormone_recep PF00104.30 EDK41536.1 - 0.027 14.0 3.5 0.028 14.0 3.5 1.1 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor E_Pc_C PF06752.12 EDK41536.1 - 0.077 13.1 0.8 0.085 13.0 0.8 1.0 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Tam41_Mmp37 PF09139.11 EDK41536.1 - 0.084 12.3 0.7 0.082 12.3 0.7 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Bromodomain PF00439.25 EDK41537.2 - 9.4e-16 57.7 0.0 2.6e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Bromodomain TFIIF_alpha PF05793.12 EDK41537.2 - 0.0004 19.1 25.9 0.00055 18.7 25.9 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EDK41537.2 - 0.018 13.3 29.2 0.024 12.9 29.2 1.1 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 EDK41537.2 - 0.023 13.5 9.6 0.03 13.1 9.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.10 EDK41537.2 - 0.17 11.2 30.2 0.23 10.7 30.2 1.1 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 EDK41537.2 - 0.19 10.9 8.6 0.37 10.0 8.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter LAP1C PF05609.12 EDK41537.2 - 0.23 10.5 18.9 3.9 6.5 15.7 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Vfa1 PF08432.10 EDK41537.2 - 0.24 11.7 20.8 0.53 10.6 20.8 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Paf1 PF03985.13 EDK41537.2 - 0.38 9.7 28.1 0.54 9.2 28.1 1.2 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.12 EDK41537.2 - 0.72 8.8 10.0 1.4 7.9 10.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop53 PF07767.11 EDK41537.2 - 1.1 8.6 29.6 1.9 7.8 29.6 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Spore_coat_CotO PF14153.6 EDK41537.2 - 1.5 8.7 24.0 3.1 7.7 24.0 1.5 1 0 0 1 1 1 0 Spore coat protein CotO AAA_11 PF13086.6 EDK41537.2 - 1.6 8.4 11.9 2.6 7.8 11.9 1.4 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.16 EDK41537.2 - 1.9 7.9 14.0 3.3 7.1 14.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 CobT PF06213.12 EDK41537.2 - 2.2 7.6 29.0 3.6 6.9 29.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 EDK41537.2 - 2.3 6.9 17.1 3.4 6.4 17.1 1.2 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 EDK41537.2 - 3.2 7.7 10.9 5.8 6.9 10.9 1.5 1 0 0 1 1 1 0 Protein Family FAM60A DUF4551 PF15087.6 EDK41537.2 - 3.3 6.4 15.0 4.7 5.9 15.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF4746 PF15928.5 EDK41537.2 - 3.3 7.0 26.9 5.1 6.4 26.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) V_ATPase_I PF01496.19 EDK41537.2 - 4.7 5.0 12.9 7.5 4.3 12.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MFS_1 PF07690.16 EDK41538.2 - 1.2e-28 100.1 19.0 1.8e-28 99.5 19.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Amidase PF01425.21 EDK41539.2 - 5e-99 332.3 0.0 1.9e-98 330.4 0.0 1.8 1 1 0 1 1 1 1 Amidase Peptidase_M16_C PF05193.21 EDK41540.2 - 3e-16 60.0 0.0 3.8e-14 53.1 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDK41540.2 - 2.4e-07 30.8 0.0 6.9e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) UFD1 PF03152.14 EDK41541.2 - 1.8e-21 76.4 0.0 4.6e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EDK41541.2 - 2.7e-05 24.3 0.6 2.7e-05 24.3 0.6 2.3 2 0 0 2 2 2 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Peptidase_S8 PF00082.22 EDK41542.2 - 1.9e-32 112.7 8.9 3.9e-32 111.7 8.9 1.5 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDK41542.2 - 5.2e-11 43.1 0.0 1.6e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 Peptidase inhibitor I9 UQ_con PF00179.26 EDK41543.1 - 1.5e-48 164.0 0.1 1.7e-48 163.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDK41543.1 - 0.00075 19.2 0.1 0.0015 18.2 0.1 1.6 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDK41543.1 - 0.0091 16.3 0.1 0.017 15.4 0.1 1.6 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 EDK41543.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain RP-C_C PF11800.8 EDK41545.2 - 0.06 13.4 1.0 0.14 12.2 1.0 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region Fmp27_SW PF10305.9 EDK41545.2 - 1.9 9.3 11.6 0.042 14.5 2.3 2.9 3 1 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain Peptidase_M41 PF01434.18 EDK41546.2 - 2e-67 226.7 0.0 4.2e-67 225.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EDK41546.2 - 6.5e-43 146.3 0.2 1e-41 142.5 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDK41546.2 - 4e-10 39.3 0.1 1.1e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDK41546.2 - 0.00032 21.0 0.6 0.00032 21.0 0.6 2.1 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 EDK41546.2 - 0.0015 18.5 0.5 0.15 12.1 0.1 3.5 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EDK41546.2 - 0.0034 17.1 0.1 0.033 14.0 0.0 2.6 2 1 1 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDK41546.2 - 0.0036 16.6 0.0 0.0068 15.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDK41546.2 - 0.005 17.1 1.2 2.7 8.3 0.1 3.9 4 0 0 4 4 4 1 AAA domain AAA_17 PF13207.6 EDK41546.2 - 0.0056 17.1 0.0 0.026 14.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EDK41546.2 - 0.0097 16.0 2.5 0.052 13.7 0.0 3.3 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EDK41546.2 - 0.043 13.6 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 EDK41546.2 - 0.05 14.0 0.2 0.22 11.9 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain Exo_endo_phos PF03372.23 EDK41547.2 - 9.1e-08 31.9 0.5 1.3e-07 31.4 0.5 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LCAT PF02450.15 EDK41548.2 - 5.5e-06 25.8 0.0 9.1e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EDK41548.2 - 2.9e-05 23.5 0.0 5.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK41548.2 - 0.00049 19.8 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 EDK41548.2 - 0.003 17.2 0.0 0.0054 16.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Abhydrolase_6 PF12697.7 EDK41548.2 - 0.004 17.8 0.0 0.0097 16.5 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EDK41548.2 - 0.011 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_5 PF12695.7 EDK41548.2 - 0.014 15.1 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family TcdB_N PF12918.7 EDK41548.2 - 0.044 14.1 0.5 0.12 12.7 0.5 1.7 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Palm_thioest PF02089.15 EDK41548.2 - 0.047 13.5 0.1 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 Palmitoyl protein thioesterase PGAP1 PF07819.13 EDK41548.2 - 0.1 12.3 0.0 0.31 10.7 0.0 1.8 1 0 0 1 1 1 0 PGAP1-like protein zf-CSL PF05207.13 EDK41549.2 - 1e-18 66.8 0.5 1.8e-18 66.0 0.5 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EDK41549.2 - 2.5e-17 62.7 0.2 4.3e-17 62.0 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain RNA_pol_I_A49 PF06870.12 EDK41550.2 - 2.2e-119 398.8 1.0 2.7e-119 398.5 1.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor NAP PF00956.18 EDK41551.2 - 1.3e-19 70.4 6.0 2e-19 69.8 6.0 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) APG5 PF04106.12 EDK41551.2 - 0.093 12.3 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg5 FAD_binding_3 PF01494.19 EDK41552.2 - 5.1e-19 68.7 0.0 3.8e-14 52.7 0.0 2.9 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EDK41552.2 - 2.1e-05 23.7 0.1 0.0011 18.1 0.1 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EDK41552.2 - 0.0012 18.2 0.0 0.0027 17.0 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EDK41552.2 - 0.0034 16.5 0.0 0.0049 16.0 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Trp_halogenase PF04820.14 EDK41552.2 - 0.0049 15.8 0.0 0.38 9.5 0.0 2.2 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EDK41552.2 - 0.0095 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 EDK41552.2 - 0.021 14.4 0.1 0.051 13.2 0.1 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK41552.2 - 0.023 13.8 0.2 0.041 13.0 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 EDK41552.2 - 0.1 12.9 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDK41552.2 - 0.15 10.8 0.1 0.21 10.2 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein GST_N_5 PF18485.1 EDK41552.2 - 0.18 12.2 0.0 0.9 9.9 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain K_oxygenase PF13434.6 EDK41552.2 - 0.2 10.7 0.0 0.67 9.0 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) DUF676 PF05057.14 EDK41553.2 - 9.4e-08 31.8 0.0 5.3e-07 29.4 0.1 2.1 2 1 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EDK41553.2 - 5.2e-07 29.6 0.0 1e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 EDK41553.2 - 9.5e-07 28.4 0.0 0.0064 15.8 0.0 2.9 3 0 0 3 3 3 2 Alpha/beta hydrolase of unknown function (DUF915) Palm_thioest PF02089.15 EDK41553.2 - 1e-05 25.5 0.0 4.6e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EDK41553.2 - 0.00037 20.2 0.0 0.00099 18.8 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 EDK41553.2 - 0.0015 17.7 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EDK41553.2 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EDK41553.2 - 0.18 12.4 0.0 0.31 11.6 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Aldedh PF00171.22 EDK41554.2 - 1.1e-112 376.9 1.6 1.3e-112 376.7 1.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4964 PF16334.5 EDK41554.2 - 0.12 12.0 0.0 3.6 7.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4964) BAR_3 PF16746.5 EDK41555.2 - 1e-18 67.9 1.0 2.3e-18 66.8 0.3 1.9 2 0 0 2 2 2 1 BAR domain of APPL family PH PF00169.29 EDK41555.2 - 1.1e-09 38.7 0.0 4.8e-09 36.7 0.0 2.2 1 0 0 1 1 1 1 PH domain VASt PF16016.5 EDK41555.2 - 1.5e-06 28.7 0.0 3.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain Vir_act_alpha_C PF10400.9 EDK41555.2 - 0.033 14.8 1.8 15 6.4 0.0 3.1 3 0 0 3 3 3 0 Virulence activator alpha C-term Stathmin PF00836.19 EDK41555.2 - 0.084 12.8 0.1 0.67 9.9 0.0 2.4 2 0 0 2 2 2 0 Stathmin family Methuselah_N PF06652.12 EDK41555.2 - 0.12 12.3 0.2 1.7 8.5 0.0 2.8 3 0 0 3 3 3 0 Methuselah N-terminus HLH PF00010.26 EDK41556.2 - 1.6e-15 56.7 0.2 3.6e-15 55.7 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MIF4G_like PF09088.11 EDK41556.2 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 MIF4G like 30K_MP_C_Ter PF11330.8 EDK41556.2 - 0.58 9.4 3.1 11 5.3 0.4 2.1 2 0 0 2 2 2 0 C-Terminal of 30K viral movement proteins LMBR1 PF04791.16 EDK41557.2 - 2.7e-72 244.3 25.9 3.2e-72 244.1 25.9 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein ADH_N PF08240.12 EDK41558.2 - 1.4e-06 28.1 0.0 2.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2722 PF10846.8 EDK41559.2 - 2.7e-98 330.0 32.9 5e-97 325.8 32.9 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2722) FAM176 PF14851.6 EDK41559.2 - 0.26 11.0 0.8 0.48 10.1 0.8 1.4 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 EDK41559.2 - 9.8 4.9 8.6 17 4.1 8.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SHQ1 PF04925.15 EDK41560.2 - 5.4e-67 224.8 0.1 7.5e-67 224.3 0.1 1.2 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.17 EDK41561.2 - 2.3e-118 395.1 0.1 2.7e-118 394.8 0.1 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Arginase PF00491.21 EDK41562.2 - 1.9e-83 280.2 0.0 2.5e-83 279.8 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EDK41562.2 - 0.0071 16.6 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 UPF0489 domain Na_H_Exchanger PF00999.21 EDK41563.2 - 1.5e-32 112.9 31.3 1.4e-23 83.3 20.3 2.0 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family S1FA PF04689.13 EDK41563.2 - 3.5 7.8 6.2 0.91 9.7 1.8 2.3 2 0 0 2 2 2 0 DNA binding protein S1FA HELP PF03451.14 EDK41564.2 - 0.0011 18.8 0.0 14 5.6 0.0 4.0 3 1 1 4 4 4 3 HELP motif ATP_sub_h PF10775.9 EDK41566.1 - 0.15 12.1 9.0 20 5.3 0.1 4.2 2 1 2 4 4 4 0 ATP synthase complex subunit h Sugar_tr PF00083.24 EDK41567.2 - 4.8e-81 272.9 31.8 5.6e-81 272.7 31.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41567.2 - 1.6e-33 116.1 38.0 1.9e-29 102.7 18.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Cep3 PF16846.5 EDK41568.2 - 5.3e-11 41.7 0.3 1.1e-10 40.6 0.1 1.5 1 1 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B bZIP_2 PF07716.15 EDK41568.2 - 0.009 16.1 0.9 0.019 15.1 0.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EDK41568.2 - 0.011 15.9 0.4 0.03 14.4 0.4 1.7 1 0 0 1 1 1 0 bZIP transcription factor JIP_LZII PF16471.5 EDK41568.2 - 0.021 15.0 0.6 0.062 13.5 0.6 1.7 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Zn_clus PF00172.18 EDK41568.2 - 0.05 13.7 15.3 0.1 12.7 15.3 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_TACC PF12709.7 EDK41568.2 - 0.067 13.6 0.6 0.2 12.1 0.6 1.7 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins HALZ PF02183.18 EDK41568.2 - 0.067 13.4 1.7 0.18 12.0 1.7 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper APC_N_CC PF16689.5 EDK41568.2 - 1.8 8.7 4.9 0.46 10.6 1.1 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Alpha-amylase PF00128.24 EDK41569.2 - 2.5e-118 395.5 0.3 3.7e-118 394.9 0.3 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EDK41569.2 - 0.00013 21.2 0.1 0.00023 20.4 0.1 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Malt_amylase_C PF16657.5 EDK41569.2 - 0.085 13.0 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Asp PF00026.23 EDK41570.2 - 2.1e-59 201.5 8.9 2.6e-59 201.2 8.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDK41570.2 - 4.3e-07 30.3 2.5 0.00013 22.3 1.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal adh_short PF00106.25 EDK41571.2 - 1.5e-19 70.3 0.0 4.4e-17 62.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDK41571.2 - 2e-11 43.9 0.0 5.1e-11 42.6 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDK41571.2 - 7.2e-07 29.3 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDK41571.2 - 0.00015 21.7 0.4 0.0005 20.0 0.1 2.0 2 1 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EDK41571.2 - 0.00094 18.7 0.0 0.0014 18.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EDK41571.2 - 0.022 15.2 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 EDK41571.2 - 0.043 13.1 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EDK41571.2 - 0.069 12.5 0.0 0.19 11.1 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 EDK41572.2 - 3.2e-62 210.8 0.0 4.2e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_4 PF12799.7 EDK41573.2 - 0.0063 16.9 21.8 9.8 6.8 0.2 7.7 5 3 3 8 8 8 2 Leucine Rich repeats (2 copies) LysM PF01476.20 EDK41573.2 - 0.063 13.4 0.0 0.24 11.5 0.0 2.0 1 0 0 1 1 1 0 LysM domain LRR_8 PF13855.6 EDK41573.2 - 0.14 12.0 8.8 0.34 10.7 0.1 5.1 6 0 0 6 6 6 0 Leucine rich repeat LRR_2 PF07723.13 EDK41573.2 - 0.98 10.2 3.9 21 6.0 0.5 3.3 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_4 PF12799.7 EDK41574.2 - 7.2e-07 29.4 12.0 0.029 14.8 0.4 4.7 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK41574.2 - 3.1e-06 26.8 8.6 0.17 11.6 0.2 4.6 1 1 4 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 EDK41574.2 - 0.00013 21.8 1.2 12 6.3 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich repeat FNIP PF05725.12 EDK41574.2 - 0.0035 17.5 6.6 0.24 11.6 0.1 4.5 4 2 1 5 5 5 2 FNIP Repeat LRR_1 PF00560.33 EDK41574.2 - 0.0037 17.6 7.7 18 6.3 0.0 6.5 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_3 PF07725.12 EDK41574.2 - 0.22 11.4 3.4 5 7.1 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.7 EDK41575.2 - 1.2e-09 38.3 42.1 0.016 15.6 0.2 11.3 6 4 5 11 11 11 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK41575.2 - 1.1e-05 25.0 27.7 0.026 14.3 0.0 8.8 5 2 5 10 10 10 5 Leucine rich repeat FNIP PF05725.12 EDK41575.2 - 0.00017 21.7 17.5 0.2 11.8 0.3 7.3 5 3 0 6 6 6 2 FNIP Repeat F-box PF00646.33 EDK41575.2 - 0.33 10.9 2.5 2.5 8.1 0.2 3.2 3 0 0 3 3 3 0 F-box domain LRR_8 PF13855.6 EDK41577.2 - 1.7e-07 30.9 26.1 0.00069 19.3 0.6 7.1 3 1 6 10 10 10 5 Leucine rich repeat LRR_4 PF12799.7 EDK41577.2 - 7.1e-06 26.3 31.4 0.16 12.4 2.3 8.4 7 3 3 10 10 10 6 Leucine Rich repeats (2 copies) FNIP PF05725.12 EDK41577.2 - 0.0022 18.1 31.5 0.16 12.2 1.4 7.0 8 0 0 8 8 8 4 FNIP Repeat LRR_6 PF13516.6 EDK41577.2 - 0.01 15.8 15.7 12 6.3 0.0 8.7 11 0 0 11 11 11 0 Leucine Rich repeat Pyr_redox_2 PF07992.14 EDK41578.2 - 1.8e-32 112.8 0.3 2.2e-32 112.5 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDK41578.2 - 3.1e-10 40.5 0.1 1.3e-06 28.8 0.1 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDK41578.2 - 1.7e-07 30.8 0.6 0.0011 18.3 0.1 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDK41578.2 - 1.9e-05 23.8 2.9 0.042 12.7 0.2 3.3 4 0 0 4 4 4 2 Tryptophan halogenase K_oxygenase PF13434.6 EDK41578.2 - 0.00012 21.4 0.1 0.00032 20.0 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDK41578.2 - 0.0033 17.4 1.6 5.8 6.9 0.0 4.2 3 1 1 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EDK41578.2 - 0.078 12.0 0.0 14 4.6 0.0 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein Lipase PF00151.19 EDK41578.2 - 0.094 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipase GIDA PF01134.22 EDK41578.2 - 1.8 7.6 6.4 0.25 10.4 0.9 2.3 1 1 2 3 3 3 0 Glucose inhibited division protein A Mannosidase_ig PF17786.1 EDK41579.2 - 1.2e-10 41.9 0.1 2.6e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Ig_mannosidase PF17753.1 EDK41579.2 - 8.1e-05 22.3 0.2 0.00018 21.2 0.1 1.6 2 0 0 2 2 2 1 Ig-fold domain Ammonium_transp PF00909.21 EDK41580.1 - 2.3e-88 296.6 21.9 2.7e-88 296.4 21.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Fungal_trans_2 PF11951.8 EDK41582.2 - 9.5e-39 133.3 5.2 1.1e-38 133.0 5.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDK41582.2 - 6.2e-08 32.6 7.6 1.1e-07 31.9 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNF220 PF15926.5 EDK41582.2 - 1.7 8.2 3.8 2.7 7.5 3.8 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Hydantoinase_B PF02538.14 EDK41583.2 - 1.2e-94 317.6 7.6 1.4e-94 317.4 7.6 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_B PF02538.14 EDK41584.1 - 2e-64 217.9 0.1 2.4e-64 217.6 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Pox_P4B PF03292.14 EDK41584.1 - 0.03 12.6 0.0 0.033 12.5 0.0 1.2 1 1 0 1 1 1 0 Poxvirus P4B major core protein Hydantoinase_A PF01968.18 EDK41586.1 - 1.7e-84 283.6 0.2 8.5e-83 278.0 0.0 2.1 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDK41586.1 - 4.1e-59 199.3 1.7 1.8e-57 193.9 0.1 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Radical_SAM PF04055.21 EDK41586.1 - 0.022 15.1 0.6 0.22 11.9 0.2 2.7 2 1 0 2 2 2 0 Radical SAM superfamily DAO PF01266.24 EDK41587.2 - 2.8e-18 66.6 0.2 3.5e-18 66.3 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK41587.2 - 2e-05 23.9 0.2 5e-05 22.6 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EDK41587.2 - 7.5e-05 22.1 0.0 0.00011 21.5 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EDK41587.2 - 0.0001 21.7 0.1 0.052 12.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EDK41587.2 - 0.0013 18.7 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EDK41587.2 - 0.0016 18.7 0.0 0.0044 17.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EDK41587.2 - 0.0016 17.8 0.0 0.0025 17.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDK41587.2 - 0.0024 17.2 0.0 0.28 10.5 0.0 2.9 2 1 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EDK41587.2 - 0.0027 17.7 0.3 1.3 9.0 0.3 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EDK41587.2 - 0.0047 16.2 0.1 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EDK41587.2 - 0.006 16.2 0.1 0.011 15.3 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EDK41587.2 - 0.021 15.4 0.0 0.062 13.9 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TPMT PF05724.11 EDK41587.2 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) ApbA PF02558.16 EDK41587.2 - 0.14 11.8 0.1 0.31 10.7 0.1 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA MFS_1 PF07690.16 EDK41588.2 - 2.5e-33 115.5 28.0 3.3e-33 115.1 28.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK41588.2 - 5e-09 35.9 5.5 5e-09 35.9 5.5 2.0 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB FAD_binding_6 PF00970.24 EDK41589.2 - 7.2e-11 42.3 0.0 9.1e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain MFS_1 PF07690.16 EDK41590.1 - 0.00029 19.9 14.2 0.00049 19.1 14.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3147 PF11345.8 EDK41590.1 - 0.086 13.2 0.6 0.086 13.2 0.6 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3147) Globin PF00042.22 EDK41591.2 - 2.8e-10 40.7 0.0 8.2e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Globin Protoglobin PF11563.8 EDK41591.2 - 0.027 14.4 0.0 0.039 13.8 0.0 1.4 1 1 0 1 1 1 0 Protoglobin Epimerase PF01370.21 EDK41592.1 - 1.8e-06 27.6 0.0 2.8e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family FAD_binding_6 PF00970.24 EDK41593.2 - 2.9e-11 43.6 0.0 6.3e-11 42.5 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EDK41593.2 - 3.4e-07 30.9 0.0 9.2e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EDK41593.2 - 0.07 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Epimerase PF01370.21 EDK41594.1 - 0.0014 18.2 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2145 PF09916.9 EDK41596.2 - 0.14 11.8 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2145) UQ_con PF00179.26 EDK41599.1 - 6.1e-46 155.6 0.0 6.9e-46 155.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDK41599.1 - 0.0032 17.2 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDK41599.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EDK41599.1 - 0.15 12.4 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain PhoLip_ATPase_C PF16212.5 EDK41600.2 - 2e-73 247.2 31.2 2e-73 247.2 31.2 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EDK41600.2 - 2.2e-10 40.5 0.0 9.7e-10 38.4 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDK41600.2 - 1.6e-09 38.4 3.2 5.9e-06 26.7 0.2 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDK41600.2 - 6.3e-06 25.8 0.0 6.3e-06 25.8 0.0 3.0 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDK41600.2 - 0.0035 17.1 0.1 0.01 15.6 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4293 PF14126.6 EDK41600.2 - 0.009 16.3 2.1 0.029 14.6 2.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4293) PhoLip_ATPase_N PF16209.5 EDK41600.2 - 0.016 14.9 0.6 0.042 13.5 0.6 1.7 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal HAD PF12710.7 EDK41600.2 - 0.13 12.6 0.2 12 6.3 0.1 2.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 EDK41601.1 - 1.2e-68 227.1 4.6 3.4e-24 84.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ACAS_N PF16177.5 EDK41601.1 - 0.26 11.2 2.9 0.49 10.3 2.9 1.4 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus SAM_decarbox PF01536.16 EDK41603.2 - 6e-132 440.0 4.0 6.9e-132 439.8 4.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Dynamin_M PF01031.20 EDK41604.2 - 1.9e-97 325.9 0.1 3.2e-97 325.2 0.1 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EDK41604.2 - 8.7e-56 188.6 0.1 1.5e-55 187.8 0.1 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EDK41604.2 - 1.9e-26 92.0 5.1 1.9e-26 92.0 5.1 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EDK41604.2 - 5.6e-05 23.2 0.6 0.00069 19.7 0.6 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EDK41604.2 - 0.05 14.0 0.0 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Pkinase PF00069.25 EDK41605.2 - 1e-72 244.7 0.0 1.3e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41605.2 - 3.9e-43 147.6 0.0 5e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK41605.2 - 1.8e-07 30.8 0.0 8e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDK41605.2 - 0.0003 19.7 0.0 0.00057 18.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EDK41605.2 - 0.028 14.1 0.1 0.37 10.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDK41605.2 - 0.061 13.2 0.3 1.2 9.0 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 EDK41605.2 - 0.08 13.7 0.5 0.3 11.8 0.1 2.3 2 1 0 2 2 2 0 Protein kinase C terminal domain Macro PF01661.21 EDK41606.2 - 2.6e-24 85.5 0.0 3.2e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Macro domain WD40 PF00400.32 EDK41607.2 - 0.072 14.0 6.2 1.2 10.1 0.6 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat SHE3 PF17078.5 EDK41608.2 - 3.2e-64 216.8 28.5 3.2e-64 216.8 28.5 1.6 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 Jnk-SapK_ap_N PF09744.9 EDK41608.2 - 0.00016 21.9 24.9 0.00079 19.7 10.9 3.7 1 1 2 3 3 3 2 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 EDK41608.2 - 0.00033 20.2 16.8 0.00033 20.2 16.8 2.2 1 1 1 2 2 2 1 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 EDK41608.2 - 0.00035 20.6 3.7 0.00035 20.6 3.7 4.4 1 1 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KASH_CCD PF14662.6 EDK41608.2 - 0.00082 19.3 25.4 0.0013 18.6 8.7 3.6 1 1 1 3 3 3 2 Coiled-coil region of CCDC155 or KASH DUF3450 PF11932.8 EDK41608.2 - 0.0015 17.9 22.2 0.039 13.2 5.8 3.7 2 1 2 4 4 4 2 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EDK41608.2 - 0.0042 17.3 20.4 3.8 7.8 0.5 4.4 2 1 2 4 4 4 2 TATA element modulatory factor 1 TATA binding Tup_N PF08581.10 EDK41608.2 - 0.009 16.3 10.2 0.7 10.2 3.5 3.4 1 1 2 3 3 3 2 Tup N-terminal GAS PF13851.6 EDK41608.2 - 0.0099 15.2 32.9 0.019 14.3 23.2 3.2 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding DivIC PF04977.15 EDK41608.2 - 0.048 13.4 12.5 0.55 10.0 0.5 3.5 1 1 1 3 3 3 0 Septum formation initiator ZapB PF06005.12 EDK41608.2 - 0.075 13.5 15.5 1.1 9.7 3.2 4.0 2 1 1 3 3 3 0 Cell division protein ZapB MCC-bdg_PDZ PF10506.9 EDK41608.2 - 0.14 12.2 0.1 0.14 12.2 0.1 4.1 2 1 3 5 5 5 0 PDZ domain of MCC-2 bdg protein for Usher syndrome ALS_ss_C PF10369.9 EDK41608.2 - 0.16 12.2 0.5 2.2 8.5 0.1 2.8 2 1 0 2 2 2 0 Small subunit of acetolactate synthase HALZ PF02183.18 EDK41608.2 - 0.19 12.0 15.0 1.2 9.4 2.5 4.4 4 1 0 4 4 3 0 Homeobox associated leucine zipper Nebulin PF00880.18 EDK41608.2 - 0.27 11.2 3.3 0.43 10.6 0.2 2.9 2 0 0 2 2 2 0 Nebulin repeat FlaC_arch PF05377.11 EDK41608.2 - 0.75 10.2 10.4 6.9 7.1 0.2 4.0 4 1 1 5 5 4 0 Flagella accessory protein C (FlaC) DUF3552 PF12072.8 EDK41608.2 - 1.8 8.0 17.2 0.64 9.4 1.4 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF3552) HrpB7 PF09486.10 EDK41608.2 - 2.2 8.7 8.0 5.1 7.5 0.1 2.8 2 1 1 3 3 2 0 Bacterial type III secretion protein (HrpB7) Cep57_CLD_2 PF14197.6 EDK41608.2 - 2.4 8.3 20.2 13 6.0 1.6 4.0 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 NusB PF01029.18 EDK41608.2 - 3.8 7.8 11.1 0.66 10.2 1.1 2.7 2 1 0 2 2 2 0 NusB family JIP_LZII PF16471.5 EDK41608.2 - 4 7.7 11.6 8.6 6.6 0.4 3.6 3 1 1 4 4 3 0 JNK-interacting protein leucine zipper II Lebercilin PF15619.6 EDK41608.2 - 4 7.0 27.6 0.52 9.9 15.1 3.8 2 2 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease AI-2E_transport PF01594.16 EDK41608.2 - 4.3 6.4 3.7 20 4.2 0.1 2.8 2 1 1 3 3 3 0 AI-2E family transporter Fez1 PF06818.15 EDK41608.2 - 4.9 7.6 29.6 1.8e+04 -7.3 28.8 3.3 1 1 0 1 1 0 0 Fez1 TACC_C PF05010.14 EDK41608.2 - 8 6.2 24.4 4.3 7.1 9.2 3.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF148 PF02520.17 EDK41608.2 - 9.8 6.3 19.2 2.7 8.2 0.8 4.2 1 1 3 4 4 4 0 Domain of unknown function DUF148 DUF3074 PF11274.8 EDK41609.1 - 4.3e-33 114.8 0.0 5.4e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) AAA PF00004.29 EDK41611.2 - 2.6e-10 40.8 0.0 5.6e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDK41611.2 - 3e-06 27.3 0.0 6.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDK41611.2 - 5.5e-06 26.7 0.0 1.8e-05 25.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDK41611.2 - 8.4e-06 25.9 0.0 3.7e-05 23.8 0.0 2.2 2 0 0 2 2 1 1 AAA domain Rad17 PF03215.15 EDK41611.2 - 3.9e-05 23.6 0.2 0.00028 20.9 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EDK41611.2 - 0.00018 22.0 0.0 0.0023 18.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EDK41611.2 - 0.00044 20.0 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EDK41611.2 - 0.0056 17.0 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 EDK41611.2 - 0.013 15.3 0.0 0.013 15.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDK41611.2 - 0.026 14.9 0.0 0.15 12.5 0.0 2.4 1 1 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 EDK41611.2 - 0.034 13.9 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 EDK41611.2 - 0.083 12.2 0.2 0.55 9.5 0.0 2.1 1 1 1 2 2 2 0 KaiC AAA_30 PF13604.6 EDK41611.2 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 EDK41611.2 - 0.16 12.3 1.9 3.6 7.8 0.0 2.6 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_3 PF07726.11 EDK41611.2 - 0.16 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CRAL_TRIO PF00650.20 EDK41612.1 - 3.7e-37 127.5 0.0 5.6e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDK41612.1 - 1.9e-08 34.4 0.2 4.8e-08 33.1 0.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EDK41612.1 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 EDK41612.1 - 0.093 12.9 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) RasGAP PF00616.19 EDK41613.2 - 4.1e-64 216.1 0.3 9e-64 215.0 0.3 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EDK41613.2 - 0.00038 20.7 0.0 0.0011 19.2 0.0 1.8 1 0 0 1 1 1 1 C2 domain APP_N PF02177.16 EDK41613.2 - 0.058 13.8 0.2 2.3 8.6 0.1 3.1 3 0 0 3 3 3 0 Amyloid A4 N-terminal heparin-binding UPF1_Zn_bind PF09416.10 EDK41614.2 - 5.1e-65 218.1 7.7 5.1e-65 218.1 7.7 2.5 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EDK41614.2 - 2.5e-59 200.3 0.0 5.4e-59 199.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDK41614.2 - 2.5e-51 175.0 8.0 7.3e-27 94.8 1.0 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EDK41614.2 - 2e-28 98.4 0.0 4e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EDK41614.2 - 9.1e-14 51.6 0.2 5.1e-13 49.2 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDK41614.2 - 2.7e-13 50.5 0.2 6.7e-13 49.2 0.2 1.7 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDK41614.2 - 1.7e-05 24.9 0.2 3.2e-05 24.0 0.2 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDK41614.2 - 5e-05 23.1 0.4 9.2e-05 22.3 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EDK41614.2 - 0.00058 19.2 6.7 0.0097 15.2 0.3 4.1 4 1 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EDK41614.2 - 0.0015 18.3 4.8 1.1 8.9 0.0 3.6 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 EDK41614.2 - 0.0016 18.0 4.0 0.22 11.0 3.6 2.4 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EDK41614.2 - 0.012 15.0 0.0 0.029 13.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 EDK41614.2 - 0.025 14.8 0.1 0.087 13.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 EDK41614.2 - 0.038 13.2 0.0 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase UvrD_C_2 PF13538.6 EDK41614.2 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain THP2 PF09432.10 EDK41615.2 - 0.43 10.6 5.8 1.3 9.1 0.0 3.2 4 0 0 4 4 4 0 Tho complex subunit THP2 ApoO PF09769.9 EDK41615.2 - 9.5 6.2 7.2 24 4.9 0.9 2.7 2 1 0 2 2 2 0 Apolipoprotein O Epimerase PF01370.21 EDK41616.2 - 1.1e-16 61.0 0.0 1.8e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41616.2 - 8.4e-16 57.8 0.0 1.2e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDK41616.2 - 1.8e-10 41.0 0.0 4.8e-10 39.6 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDK41616.2 - 8.5e-09 35.0 0.0 9.8e-08 31.5 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EDK41616.2 - 3.3e-08 33.3 0.0 1.1e-07 31.6 0.0 1.8 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EDK41616.2 - 0.0019 17.8 0.1 0.027 14.0 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EDK41616.2 - 0.0033 16.9 0.0 0.013 15.0 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 EDK41616.2 - 0.14 12.8 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Abhydrolase_1 PF00561.20 EDK41617.2 - 2.5e-16 60.1 0.0 1.9e-13 50.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK41617.2 - 4.4e-15 56.9 0.3 5.5e-15 56.6 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK41617.2 - 6.6e-06 25.6 0.0 4.7e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 TRAUB PF08164.12 EDK41618.2 - 1.8e-24 86.1 0.2 2e-23 82.7 0.0 3.0 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EDK41618.2 - 4.1e-24 85.8 5.0 4.1e-24 85.8 5.0 3.5 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor CDK2AP PF09806.9 EDK41618.2 - 0.63 10.1 11.0 1.9 8.5 11.0 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein KRE1 PF17056.5 EDK41619.2 - 1.3e-24 85.7 10.6 2e-24 85.1 10.6 1.3 1 0 0 1 1 1 1 Killer toxin-resistance protein 1 IF4E PF01652.18 EDK41620.1 - 7.3e-56 188.4 0.9 8.7e-56 188.1 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Hydrolase_4 PF12146.8 EDK41621.2 - 3.5e-15 55.9 0.0 9.9e-12 44.6 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK41621.2 - 1.3e-08 34.8 0.3 8.4e-07 28.9 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK41621.2 - 3.4e-05 24.6 0.0 4.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EDK41621.2 - 5.3e-05 23.3 0.0 0.0032 17.4 0.0 2.4 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF818 PF05677.12 EDK41621.2 - 8.8e-05 21.6 0.3 0.00013 21.0 0.3 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 EDK41621.2 - 0.0015 18.0 0.0 0.011 15.2 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EDK41621.2 - 0.0087 15.9 0.1 0.06 13.1 0.1 2.0 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.18 EDK41621.2 - 0.018 14.6 0.0 0.28 10.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Lipase_3 PF01764.25 EDK41621.2 - 0.023 14.6 0.0 0.042 13.7 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 3) UPF0227 PF05728.12 EDK41621.2 - 0.061 13.3 0.3 0.26 11.2 0.3 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) Esterase PF00756.20 EDK41621.2 - 0.069 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Abhydro_lipase PF04083.16 EDK41621.2 - 0.089 12.4 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region AXE1 PF05448.12 EDK41621.2 - 0.1 11.3 0.0 0.31 9.7 0.0 1.8 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.8 EDK41621.2 - 0.19 11.2 0.1 0.31 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) WD40 PF00400.32 EDK41622.2 - 7.3e-09 36.1 2.9 2.7e-05 24.8 0.1 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EDK41622.2 - 5.5e-07 29.1 8.2 5.5e-07 29.1 8.2 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EDK41622.2 - 0.0029 17.9 7.3 0.0029 17.9 7.3 3.2 5 0 0 5 5 5 1 Ring finger domain zf-rbx1 PF12678.7 EDK41622.2 - 0.12 12.7 8.7 0.39 11.0 8.7 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain SLD5_C PF16922.5 EDK41623.2 - 1.4e-12 47.6 0.1 2.5e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EDK41623.2 - 0.0012 19.2 0.8 0.0035 17.8 0.6 1.8 1 1 1 2 2 2 1 GINS complex protein tRNA-synt_1e PF01406.19 EDK41623.2 - 0.064 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain WD40 PF00400.32 EDK41624.2 - 0.29 12.1 9.1 11 7.1 0.1 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Pox_Ag35 PF03286.14 EDK41624.2 - 0.69 9.7 5.0 1.2 8.9 5.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rad21_Rec8_N PF04825.13 EDK41625.2 - 4.3e-27 94.4 0.4 1.2e-26 93.0 0.0 1.9 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDK41625.2 - 2.3e-07 30.0 0.0 7.1e-07 28.4 0.0 1.8 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Med2 PF11214.8 EDK41626.2 - 5.5e-33 113.1 2.8 5.5e-33 113.1 2.8 2.2 1 1 1 2 2 1 1 Mediator complex subunit 2 U79_P34 PF03064.16 EDK41626.2 - 3.9e-05 23.1 5.2 4.4e-05 23.0 5.2 1.2 1 0 0 1 1 1 1 HSV U79 / HCMV P34 ICA69 PF04629.14 EDK41626.2 - 0.024 15.0 9.9 0.032 14.6 9.9 1.2 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain TFB6 PF17110.5 EDK41626.2 - 0.05 13.3 4.9 0.095 12.4 4.9 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SOBP PF15279.6 EDK41626.2 - 0.073 13.7 1.5 0.092 13.3 1.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DDHD PF02862.17 EDK41626.2 - 0.1 12.8 2.1 0.11 12.6 2.1 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EDK41626.2 - 0.13 11.0 4.4 0.14 10.9 4.4 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EDK41626.2 - 0.21 11.4 8.0 0.3 10.9 8.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RAP1 PF07218.11 EDK41626.2 - 0.68 8.2 5.0 0.77 8.0 5.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) AAA_11 PF13086.6 EDK41626.2 - 0.74 9.5 7.5 0.95 9.2 7.5 1.2 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.8 EDK41626.2 - 0.82 8.5 10.3 1.1 8.1 10.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 EDK41626.2 - 0.86 7.8 10.9 1 7.6 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 EDK41626.2 - 1.1 7.1 4.7 1.2 7.0 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec62 PF03839.16 EDK41626.2 - 1.1 8.7 4.1 1.4 8.3 4.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Afi1 PF07792.12 EDK41626.2 - 1.4 9.4 7.8 3.1 8.3 7.8 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 EDK41626.2 - 2.1 7.0 7.7 2.4 6.8 7.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PBP_sp32 PF07222.12 EDK41626.2 - 3.4 7.0 8.6 5.3 6.4 8.6 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 FancD2 PF14631.6 EDK41626.2 - 5.2 4.3 7.1 6.6 4.0 7.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DDRGK PF09756.9 EDK41626.2 - 5.5 6.5 27.4 8.6 5.9 27.4 1.2 1 0 0 1 1 1 0 DDRGK domain DUF1682 PF07946.14 EDK41626.2 - 6.4 5.9 17.2 8.7 5.4 17.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Atrophin-1 PF03154.15 EDK41626.2 - 7 4.8 14.5 9.5 4.4 14.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family MIF4G_like_2 PF09090.11 EDK41626.2 - 7.9 5.9 11.3 12 5.3 11.3 1.2 1 0 0 1 1 1 0 MIF4G like ATP-synt_DE_N PF02823.16 EDK41627.2 - 2.5e-20 72.2 0.0 4.6e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ADH_N PF08240.12 EDK41628.2 - 6.5e-25 87.1 0.4 1.4e-24 86.1 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK41628.2 - 4.3e-23 81.7 0.2 7.4e-23 80.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDK41628.2 - 2.5e-10 40.2 0.6 5.7e-10 39.0 0.6 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EDK41628.2 - 0.00017 22.7 0.0 0.00084 20.4 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDK41628.2 - 0.00027 20.3 2.4 0.00046 19.5 2.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EDK41628.2 - 0.0028 17.0 0.2 0.021 14.1 0.3 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDK41628.2 - 0.021 13.5 0.4 0.032 13.0 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EDK41628.2 - 0.037 14.6 1.5 0.62 10.7 1.9 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_3 PF03447.16 EDK41628.2 - 0.066 13.9 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 EDK41628.2 - 0.15 11.3 0.7 0.32 10.2 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDK41628.2 - 0.15 10.9 0.6 0.23 10.3 0.6 1.2 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 EDK41628.2 - 0.3 10.1 1.2 0.41 9.7 1.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EDK41628.2 - 0.37 9.8 1.8 0.51 9.3 1.8 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EDK41628.2 - 0.74 9.1 4.7 1.2 8.4 4.7 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Mitoc_mL59 PF18126.1 EDK41629.1 - 1.6e-32 112.5 1.1 2.7e-32 111.8 1.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 LSM PF01423.22 EDK41630.1 - 6.7e-15 54.5 0.0 1.1e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDK41630.1 - 6.3e-06 26.2 0.0 9.2e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain XFP PF03894.15 EDK41630.1 - 0.19 11.4 0.0 0.25 11.1 0.0 1.1 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DER1 PF04511.15 EDK41631.2 - 6.9e-22 78.3 12.8 7.9e-22 78.1 6.8 2.1 2 0 0 2 2 2 2 Der1-like family DUF2919 PF11143.8 EDK41631.2 - 0.36 11.1 5.1 5.2 7.4 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) Na_Ca_ex PF01699.24 EDK41632.2 - 5.7e-22 78.3 48.3 1.3e-15 57.7 16.4 4.1 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 EDK41632.2 - 4.1e-13 49.8 6.3 4.1e-13 49.8 6.3 4.8 5 1 0 5 5 5 1 Inner membrane component domain LapA_dom PF06305.11 EDK41632.2 - 1.9 8.4 7.0 22 4.9 2.9 3.9 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF2417 PF10329.9 EDK41632.2 - 2.1 7.7 12.8 2.2 7.7 1.1 3.8 4 0 0 4 4 4 0 Region of unknown function (DUF2417) Alpha-amylase PF00128.24 EDK41633.1 - 6.7e-123 410.5 0.7 1.5e-122 409.4 0.7 1.5 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EDK41633.1 - 0.0011 18.2 0.1 0.0048 16.0 0.0 1.9 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain Malt_amylase_C PF16657.5 EDK41633.1 - 0.0048 17.0 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Zn_clus PF00172.18 EDK41634.2 - 7.9e-07 29.1 11.7 1.5e-06 28.2 11.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lipase_GDSL_2 PF13472.6 EDK41635.2 - 2.6e-08 34.4 0.0 4e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EDK41635.2 - 3.3e-06 27.2 0.0 4e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3196 PF11428.8 EDK41635.2 - 0.035 13.7 0.0 0.054 13.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3196) DUF1574 PF07611.11 EDK41635.2 - 0.05 12.9 0.0 0.19 11.1 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1574) PAH PF02671.21 EDK41638.2 - 3.3e-39 132.8 5.3 6.3e-19 67.8 2.3 2.4 2 0 0 2 2 2 2 Paired amphipathic helix repeat Mei5_like PF17021.5 EDK41638.2 - 0.0026 17.8 0.7 0.46 10.5 0.1 2.4 2 0 0 2 2 2 2 Putative double-strand recombination repair-like RB_B PF01857.20 EDK41638.2 - 0.1 12.6 0.7 4.9 7.2 0.1 2.3 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain Med28 PF11594.8 EDK41638.2 - 0.12 12.5 0.6 1 9.5 0.1 2.5 3 0 0 3 3 3 0 Mediator complex subunit 28 Sin3a_C PF16879.5 EDK41639.2 - 3.5e-80 269.8 7.9 1.2e-79 268.0 7.9 1.9 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 EDK41639.2 - 1e-42 144.2 0.1 3.4e-42 142.5 0.1 2.0 1 0 0 1 1 1 1 Sin3 family co-repressor Membr_traf_MHD PF10540.9 EDK41640.2 - 3e-42 144.3 0.1 3e-42 144.3 0.1 1.5 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain DUF4650 PF15509.6 EDK41640.2 - 0.051 12.9 1.1 0.077 12.3 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) C2 PF00168.30 EDK41641.2 - 8.9e-08 32.4 0.0 2.2e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 C2 domain Sec3_C_2 PF15278.6 EDK41641.2 - 0.22 11.9 1.6 12 6.3 0.1 2.9 2 0 0 2 2 2 0 Sec3 exocyst complex subunit SWIB PF02201.18 EDK41642.2 - 1.5e-22 79.2 0.5 1.5e-22 79.2 0.5 2.0 3 0 0 3 3 3 1 SWIB/MDM2 domain DEK_C PF08766.11 EDK41642.2 - 1.4e-11 44.2 0.2 4.9e-11 42.4 0.2 1.9 1 0 0 1 1 1 1 DEK C terminal domain RRS1 PF04939.12 EDK41643.1 - 7e-64 214.6 7.1 8.3e-64 214.3 7.1 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) EF_assoc_1 PF08355.12 EDK41644.2 - 5.2e-29 99.6 0.9 9e-29 98.9 0.9 1.4 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.12 EDK41644.2 - 2.8e-27 94.5 0.0 6.6e-27 93.3 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EDK41644.2 - 1.7e-21 76.5 0.0 1.2e-09 38.0 0.0 3.2 3 0 0 3 3 3 3 Ras family Roc PF08477.13 EDK41644.2 - 1.5e-13 51.0 0.0 0.00079 19.6 0.0 3.4 3 0 0 3 3 3 3 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 EDK41644.2 - 8.2e-09 34.4 3.4 0.0016 17.8 0.9 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDK41644.2 - 2.2e-08 34.4 0.1 0.0002 21.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDK41644.2 - 1.9e-07 30.5 2.3 0.0083 16.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain MMR_HSR1 PF01926.23 EDK41644.2 - 3.6e-06 27.0 0.0 0.027 14.5 0.1 2.9 2 2 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_5 PF13202.6 EDK41644.2 - 2.9e-05 23.3 4.7 0.024 14.1 3.2 2.8 2 0 0 2 2 2 2 EF hand Arf PF00025.21 EDK41644.2 - 8e-05 22.2 0.0 0.44 10.0 0.0 3.5 3 0 0 3 3 3 1 ADP-ribosylation factor family TniB PF05621.11 EDK41644.2 - 0.0015 17.9 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 2 Bacterial TniB protein Dynamin_N PF00350.23 EDK41644.2 - 0.011 15.8 0.0 0.96 9.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 EDK41644.2 - 0.045 13.5 0.1 6.9 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.6 EDK41644.2 - 0.054 13.4 1.9 1.1 9.2 0.8 2.8 2 0 0 2 2 2 0 EF-hand domain pair FeoB_N PF02421.18 EDK41644.2 - 0.056 13.0 0.0 9.6 5.7 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_16 PF13191.6 EDK41644.2 - 0.058 13.8 0.1 1.6 9.1 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EDK41644.2 - 0.15 12.0 0.0 2.3 8.1 0.0 3.0 2 1 1 3 3 3 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 EDK41644.2 - 0.16 11.3 0.0 0.65 9.3 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EDK41644.2 - 0.16 12.2 0.0 28 5.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain BolA PF01722.18 EDK41645.2 - 6.5e-13 48.8 0.0 1.7e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein eIF2A PF08662.11 EDK41646.2 - 5.2e-37 127.6 0.5 3.1e-32 112.0 1.1 3.8 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EDK41646.2 - 2.2e-08 33.8 0.1 5.1e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DPPIV_N PF00930.21 EDK41646.2 - 0.048 12.4 1.3 1.5 7.5 0.1 3.1 3 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Mto2_bdg PF12808.7 EDK41647.2 - 2.2e-06 27.8 5.5 2.2e-06 27.8 5.5 7.5 7 1 1 8 8 8 1 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF812 PF05667.11 EDK41647.2 - 0.0026 16.7 9.7 0.0026 16.7 9.7 3.5 1 1 2 3 3 3 1 Protein of unknown function (DUF812) TACC_C PF05010.14 EDK41647.2 - 0.0053 16.6 7.3 0.0053 16.6 7.3 5.3 4 3 0 4 4 4 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HJURP_mid PF12346.8 EDK41647.2 - 0.015 15.8 1.1 0.12 12.9 0.6 2.7 2 0 0 2 2 2 0 Holliday junction recognition protein-associated repeat SlyX PF04102.12 EDK41647.2 - 0.017 15.7 40.3 0.022 15.4 0.2 7.5 5 1 2 7 7 6 0 SlyX APG6_N PF17675.1 EDK41647.2 - 0.021 15.3 1.9 0.021 15.3 1.9 6.1 4 2 3 7 7 7 0 Apg6 coiled-coil region Baculo_PEP_C PF04513.12 EDK41647.2 - 0.026 14.6 1.4 0.026 14.6 1.4 5.8 4 1 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 EDK41647.2 - 0.028 13.8 39.2 0.4 10.0 5.8 3.9 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) bZIP_1 PF00170.21 EDK41647.2 - 0.043 13.9 0.1 0.043 13.9 0.1 7.7 7 2 0 7 7 7 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 EDK41647.2 - 0.097 12.7 62.0 0.57 10.2 0.0 7.2 3 3 4 7 7 7 0 TPR/MLP1/MLP2-like protein HSBP1 PF06825.12 EDK41647.2 - 0.19 11.6 4.0 13 5.7 0.1 4.1 3 0 0 3 3 3 0 Heat shock factor binding protein 1 COMM_domain PF07258.14 EDK41647.2 - 0.87 9.8 4.8 0.3 11.2 0.4 2.6 3 0 0 3 3 2 0 COMM domain EPO_TPO PF00758.18 EDK41647.2 - 2.8 7.9 11.8 3.6 7.6 7.3 3.3 2 1 1 3 3 3 0 Erythropoietin/thrombopoietin DUF5082 PF16888.5 EDK41647.2 - 5.5 7.3 44.6 1.4 9.2 2.7 5.7 4 2 1 5 5 5 0 Domain of unknown function (DUF5082) DivIC PF04977.15 EDK41647.2 - 6.3 6.7 48.0 0.19 11.5 1.0 7.3 6 1 1 7 7 7 0 Septum formation initiator Proteasome PF00227.26 EDK41648.1 - 3.1e-52 176.9 0.0 3.8e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDK41648.1 - 3e-13 49.2 0.8 4.1e-13 48.7 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DHHC PF01529.20 EDK41649.2 - 2.2e-33 115.2 9.2 3.6e-33 114.5 9.2 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase AhpC-TSA PF00578.21 EDK41650.1 - 5.1e-34 116.9 0.0 6.8e-34 116.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDK41650.1 - 4.4e-17 62.2 0.0 5.7e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDK41650.1 - 6.2e-12 45.2 0.1 1.1e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin KxDL PF10241.9 EDK41651.2 - 0.0033 17.7 6.9 0.014 15.6 0.1 2.7 1 1 1 2 2 2 2 Uncharacterized conserved protein UPF0242 PF06785.11 EDK41651.2 - 0.011 15.9 9.7 0.011 15.9 9.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TRF PF08558.10 EDK41651.2 - 0.039 13.5 15.2 1.1 8.8 10.2 2.6 1 1 1 2 2 2 0 Telomere repeat binding factor (TRF) AnfO_nitrog PF09582.10 EDK41651.2 - 0.13 11.6 8.2 0.37 10.1 6.3 2.6 1 1 1 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) CHDCT2 PF08074.11 EDK41651.2 - 0.94 9.6 9.4 0.41 10.8 6.5 1.8 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain DUF1664 PF07889.12 EDK41651.2 - 1.5 8.8 7.7 1.6 8.8 6.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PI3_PI4_kinase PF00454.27 EDK41652.2 - 7.8e-57 192.9 0.1 2.1e-56 191.5 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EDK41652.2 - 1.8e-19 70.4 1.1 1.8e-19 70.4 1.1 2.8 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EDK41652.2 - 1.2e-13 50.6 0.3 6.2e-13 48.3 0.1 2.4 2 0 0 2 2 2 1 FATC domain 4HB_MCP_1 PF12729.7 EDK41652.2 - 0.06 12.9 2.8 0.06 12.9 0.5 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction PKcGMP_CC PF16808.5 EDK41652.2 - 0.11 12.3 0.1 0.31 10.9 0.1 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GCV_T PF01571.21 EDK41653.2 - 2.7e-81 272.7 0.0 3.2e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EDK41653.2 - 7e-16 57.9 0.0 1.6e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 EDK41653.2 - 0.00015 22.0 0.0 0.093 12.9 0.0 2.5 2 1 1 3 3 3 2 Sarcosine oxidase, gamma subunit family S-layer PF07752.11 EDK41653.2 - 0.091 11.8 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 S-layer protein QWRF PF04484.12 EDK41654.2 - 9.4 5.9 9.9 23 4.6 9.9 1.6 1 0 0 1 1 1 0 QWRF family Acetyltransf_9 PF13527.7 EDK41655.2 - 0.00011 22.3 0.0 0.0033 17.5 0.0 2.7 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDK41655.2 - 0.0019 18.1 0.0 0.0035 17.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDK41655.2 - 0.098 13.1 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ubiq_cyt_C_chap PF03981.12 EDK41656.1 - 6e-40 136.6 0.1 1.3e-39 135.5 0.1 1.6 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone Aldo_ket_red PF00248.21 EDK41657.1 - 6.3e-50 170.0 0.0 7.2e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F_bP_aldolase PF01116.20 EDK41657.1 - 0.029 13.8 0.0 0.048 13.1 0.0 1.4 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Zn_clus PF00172.18 EDK41658.2 - 0.00023 21.2 13.1 0.00038 20.5 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_6 PF08348.11 EDK41658.2 - 0.088 12.7 0.2 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 YheO-like PAS domain adh_short PF00106.25 EDK41659.1 - 1e-14 54.4 0.1 9.8e-12 44.7 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDK41659.1 - 3.7e-07 30.0 0.1 4.9e-06 26.3 0.0 2.4 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EDK41659.1 - 0.01 15.8 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding Toprim_Crpt PF13342.6 EDK41659.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Oxidored_FMN PF00724.20 EDK41660.1 - 6.2e-96 321.6 0.0 7.1e-96 321.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family SBF PF01758.16 EDK41661.2 - 2.4e-36 125.3 17.2 2.4e-36 125.3 17.2 1.9 2 0 0 2 2 2 1 Sodium Bile acid symporter family Oxidored_FMN PF00724.20 EDK41662.2 - 7.1e-96 321.4 0.0 8.1e-96 321.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.20 EDK41663.2 - 6.5e-91 305.1 0.0 7.5e-91 304.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.20 EDK41664.1 - 2.2e-99 333.0 0.0 2.5e-99 332.8 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MPS-4 PF17523.2 EDK41664.1 - 0.089 12.9 0.0 13 6.0 0.0 2.4 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Oxidored_FMN PF00724.20 EDK41665.1 - 2.6e-98 329.4 0.0 3e-98 329.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ADH_N PF08240.12 EDK41666.2 - 8.1e-25 86.8 2.8 1.4e-24 86.0 2.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDK41666.2 - 2.4e-13 50.2 0.0 4.6e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDK41666.2 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EDK41666.2 - 8.5e-05 22.0 0.2 0.00017 21.0 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 EDK41666.2 - 0.029 14.1 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_2 PF03446.15 EDK41666.2 - 0.1 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase WAC_Acf1_DNA_bd PF10537.9 EDK41667.2 - 1.3e-36 125.2 1.2 3.4e-36 123.8 1.2 1.8 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EDK41667.2 - 2.7e-18 66.3 2.0 2.7e-18 66.3 2.0 3.3 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EDK41667.2 - 8.8e-15 54.8 0.0 2.1e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 DDT domain SKIP_SNW PF02731.15 EDK41668.2 - 2.4e-48 163.8 10.4 2.4e-48 163.8 10.4 1.8 2 0 0 2 2 2 1 SKIP/SNW domain GDPD PF03009.17 EDK41669.2 - 1.8e-20 73.8 0.3 1.1e-19 71.3 0.3 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family ACT_7 PF13840.6 EDK41669.2 - 0.02 14.6 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 ACT domain Peptidase_A2B PF12384.8 EDK41669.2 - 0.087 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Ty3 transposon peptidase GrpB PF04229.14 EDK41669.2 - 0.099 12.8 0.3 0.24 11.6 0.1 1.6 2 0 0 2 2 2 0 GrpB protein NUDIX PF00293.28 EDK41670.2 - 2.4e-10 40.6 0.0 4.5e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.11 EDK41670.2 - 6.4e-05 22.5 0.3 0.00012 21.7 0.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.11 EDK41670.2 - 7.1e-05 23.4 0.0 0.00017 22.2 0.0 1.7 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain DNA_ligase_ZBD PF03119.16 EDK41670.2 - 0.0056 16.7 0.2 0.014 15.4 0.2 1.7 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain DpnI PF06044.12 EDK41670.2 - 0.12 12.0 0.0 0.32 10.6 0.0 1.7 1 0 0 1 1 1 0 Dam-replacing family DEAD PF00270.29 EDK41671.2 - 9.5e-26 90.6 0.4 7.1e-25 87.8 0.1 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDK41671.2 - 3.9e-16 59.4 0.0 1.2e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDK41671.2 - 2.5e-10 40.6 0.0 1.1e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDK41671.2 - 0.014 15.7 0.0 5 7.4 0.0 3.6 2 1 1 3 3 3 0 AAA domain UvrD-helicase PF00580.21 EDK41671.2 - 0.073 12.6 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain DAP3 PF10236.9 EDK41672.2 - 5.6e-66 222.8 0.2 7.9e-66 222.3 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_5 PF07728.14 EDK41672.2 - 0.00026 21.0 0.0 0.00068 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EDK41672.2 - 0.0012 18.8 0.1 0.0027 17.6 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EDK41672.2 - 0.0043 17.4 0.2 0.013 15.9 0.1 2.0 2 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EDK41672.2 - 0.021 14.0 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Roc PF08477.13 EDK41672.2 - 0.035 14.3 0.1 0.2 11.8 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EDK41672.2 - 0.036 13.8 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EDK41672.2 - 0.06 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDK41672.2 - 0.07 13.7 0.0 0.34 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter DUF4617 PF15395.6 EDK41672.2 - 0.12 10.6 5.9 0.16 10.2 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4617) UPF0113_N PF17833.1 EDK41673.1 - 7.8e-30 103.3 0.1 1.3e-29 102.5 0.1 1.4 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EDK41673.1 - 5.7e-26 90.6 0.0 1.1e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PseudoU_synth_1 PF01416.20 EDK41674.2 - 7.8e-14 52.0 0.0 8.2e-12 45.6 0.0 2.8 3 0 0 3 3 3 1 tRNA pseudouridine synthase Lin-8 PF03353.15 EDK41674.2 - 0.049 13.2 0.1 0.074 12.6 0.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pkinase PF00069.25 EDK41675.2 - 7e-26 91.2 0.0 1.2e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41675.2 - 1.2e-14 54.3 0.0 2e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDK41675.2 - 1.9e-09 36.8 0.7 8.7e-09 34.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EDK41675.2 - 4.7e-05 23.4 0.0 0.003 17.5 0.0 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family PNISR PF15996.5 EDK41675.2 - 0.14 12.4 8.8 0.23 11.7 8.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR AIF_C PF14721.6 EDK41676.2 - 3.2 8.1 5.3 1.3 9.4 2.1 1.8 1 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ASFV_J13L PF05568.11 EDK41676.2 - 4.5 7.0 11.8 6 6.6 11.8 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein Pkinase PF00069.25 EDK41677.2 - 1e-54 185.7 0.0 1.2e-54 185.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41677.2 - 8.8e-35 120.2 0.0 1e-34 120.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDK41677.2 - 4.3e-08 32.8 0.0 5.3e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDK41677.2 - 4.4e-05 22.4 0.0 6e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDK41677.2 - 0.001 18.4 0.0 0.0014 18.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SCA7 PF08313.12 EDK41678.2 - 1.1e-30 105.4 0.1 2.7e-30 104.0 0.1 1.7 1 0 0 1 1 1 1 SCA7, zinc-binding domain Sgf11 PF08209.11 EDK41678.2 - 0.00013 21.5 0.5 0.00023 20.7 0.5 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf_C2H2_13 PF18508.1 EDK41678.2 - 0.0033 17.0 0.5 0.0075 15.8 0.0 1.8 2 0 0 2 2 2 1 Zinc finger domain RskA PF10099.9 EDK41678.2 - 0.0073 16.6 2.0 0.014 15.7 2.0 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF2043 PF09740.9 EDK41678.2 - 0.07 13.8 1.0 0.63 10.7 0.3 2.8 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2043) TAF4 PF05236.14 EDK41678.2 - 1.5 8.5 11.9 2.7 7.7 11.4 1.8 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family MCLC PF05934.11 EDK41678.2 - 1.6 7.4 3.6 2.4 6.8 3.6 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) CDK2AP PF09806.9 EDK41678.2 - 1.8 8.6 9.1 0.16 12.0 3.7 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Alpha_GJ PF03229.13 EDK41678.2 - 7.6 7.1 13.2 0.28 11.8 1.3 2.9 1 1 1 2 2 2 0 Alphavirus glycoprotein J Wyosine_form PF08608.12 EDK41679.2 - 1.8e-21 76.3 0.0 4.3e-21 75.0 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EDK41679.2 - 1.1e-20 74.6 0.0 2.6e-20 73.5 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EDK41679.2 - 1.2e-16 61.2 0.0 2.3e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin Glycos_transf_1 PF00534.20 EDK41680.2 - 8.2e-28 97.1 0.0 1.7e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDK41680.2 - 2.6e-14 53.6 0.0 4.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EDK41680.2 - 1.3e-10 41.8 0.0 3.5e-10 40.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 EDK41680.2 - 0.007 16.4 0.5 1.1 9.2 0.4 2.6 2 1 0 2 2 2 1 ALG11 mannosyltransferase N-terminus Glyco_trans_1_2 PF13524.6 EDK41680.2 - 0.047 14.1 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1414 PF07208.11 EDK41680.2 - 0.09 12.8 0.2 0.21 11.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) DUF1992 PF09350.10 EDK41681.2 - 8.8e-17 61.0 0.0 2.2e-16 59.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) rve_3 PF13683.6 EDK41681.2 - 0.27 11.0 4.0 1.7 8.5 0.1 3.9 5 0 0 5 5 5 0 Integrase core domain BSD PF03909.17 EDK41681.2 - 0.6 10.2 3.6 0.6 10.2 1.0 2.3 2 0 0 2 2 2 0 BSD domain Cwf_Cwc_15 PF04889.12 EDK41684.1 - 0.03 14.0 2.8 0.041 13.6 2.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Arf PF00025.21 EDK41685.2 - 1.1e-47 161.7 0.0 1.2e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EDK41685.2 - 2.3e-08 33.6 0.0 4.3e-08 32.7 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 EDK41685.2 - 0.00037 20.0 0.0 0.00047 19.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDK41685.2 - 0.00047 20.4 0.0 0.00064 19.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDK41685.2 - 0.0011 18.5 0.0 0.0012 18.4 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EDK41685.2 - 0.041 13.4 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDK41685.2 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase MMR_HSR1 PF01926.23 EDK41686.2 - 4.6e-16 58.9 0.0 1.1e-14 54.4 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDK41686.2 - 8.6e-08 32.3 0.1 0.0081 16.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EDK41686.2 - 1.2e-06 28.1 0.0 9.1e-06 25.3 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 EDK41686.2 - 0.021 14.1 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Arg_repressor PF01316.21 EDK41686.2 - 0.025 14.3 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Dynamin_N PF00350.23 EDK41686.2 - 0.037 14.1 0.4 0.085 12.9 0.4 1.8 1 1 0 1 1 1 0 Dynamin family cobW PF02492.19 EDK41686.2 - 0.1 12.2 0.3 0.49 10.0 0.0 2.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EDK41686.2 - 0.3 11.6 1.2 6.3 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain FtsJ PF01728.19 EDK41687.2 - 4.7e-25 88.7 0.0 7e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribosomal_L1 PF00687.21 EDK41688.1 - 5e-40 137.4 3.4 6.7e-40 137.0 3.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Coatomer_WDAD PF04053.14 EDK41689.2 - 1.5e-176 587.8 1.3 1.5e-176 587.8 1.3 1.7 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EDK41689.2 - 2.1e-38 129.6 5.8 1.3e-07 32.2 0.0 9.0 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDK41689.2 - 5.1e-09 36.3 0.1 6.9 7.0 0.0 6.8 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDK41689.2 - 1.8e-05 23.6 3.4 0.019 13.7 0.0 4.8 2 1 3 5 5 5 2 Nucleoporin Nup120/160 MetallophosC PF16370.5 EDK41689.2 - 0.021 15.1 0.1 0.096 12.9 0.0 2.1 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Ge1_WD40 PF16529.5 EDK41689.2 - 0.035 13.1 0.2 0.89 8.4 0.1 2.9 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDK41689.2 - 0.059 13.2 0.5 7.8 6.3 0.0 3.5 2 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A ALG11_N PF15924.5 EDK41690.2 - 2.3e-68 230.4 0.1 5.6e-68 229.1 0.1 1.7 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EDK41690.2 - 5.8e-17 61.7 0.0 1.2e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDK41690.2 - 6.7e-07 29.8 0.0 1.4e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Vert_HS_TF PF06546.11 EDK41690.2 - 0.15 11.7 0.1 0.99 9.0 0.0 2.0 2 0 0 2 2 2 0 Vertebrate heat shock transcription factor Peptidase_M24 PF00557.24 EDK41692.2 - 8.9e-43 146.4 0.4 1.2e-42 146.0 0.4 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Dicty_REP PF05086.12 EDK41692.2 - 2.6 5.9 4.6 3.3 5.6 4.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Phage_tube PF04985.14 EDK41693.2 - 0.05 13.3 1.6 0.073 12.8 1.6 1.2 1 0 0 1 1 1 0 Phage tail tube protein FII CytochromB561_N PF09786.9 EDK41693.2 - 0.093 11.7 5.2 0.11 11.4 5.2 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal Mucin PF01456.17 EDK41693.2 - 2.9 7.9 18.3 4.1 7.4 18.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Pannexin_like PF12534.8 EDK41693.2 - 5.8 5.9 8.0 7 5.6 8.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Aa_trans PF01490.18 EDK41694.2 - 2.1e-53 181.5 2.9 2.5e-53 181.3 2.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AOX PF01786.17 EDK41695.2 - 4.1e-93 310.9 0.2 5e-93 310.6 0.2 1.1 1 0 0 1 1 1 1 Alternative oxidase SH3_1 PF00018.28 EDK41696.2 - 5.3e-08 32.3 0.1 9.4e-08 31.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDK41696.2 - 6.4e-08 32.3 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDK41696.2 - 3.3e-07 29.9 0.0 5.6e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Hydantoinase_B PF02538.14 EDK41697.2 - 5.3e-135 450.7 0.1 7.5e-135 450.3 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Aldo_ket_red PF00248.21 EDK41697.2 - 1.3e-48 165.7 0.1 7.2e-47 160.0 0.0 2.8 2 1 0 2 2 2 1 Aldo/keto reductase family Hydantoinase_A PF01968.18 EDK41697.2 - 6.5e-34 117.5 0.0 1.5e-33 116.4 0.0 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase FANCI_HD2 PF14680.6 EDK41697.2 - 0.0062 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 FANCI helical domain 2 Hydant_A_N PF05378.13 EDK41698.1 - 5.2e-58 195.7 0.1 5.2e-58 195.7 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EDK41698.1 - 3.2e-23 82.4 0.2 2.8e-21 76.0 0.0 2.2 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Radical_SAM PF04055.21 EDK41698.1 - 0.0066 16.8 0.7 0.086 13.2 0.3 2.6 2 1 0 2 2 2 1 Radical SAM superfamily FeoB_N PF02421.18 EDK41698.1 - 0.1 12.1 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B DAO PF01266.24 EDK41699.2 - 8.5e-19 68.3 0.1 1.1e-18 68.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDK41699.2 - 3.1e-05 23.3 0.4 6.5e-05 22.2 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EDK41699.2 - 0.00011 21.6 0.0 0.00016 21.0 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EDK41699.2 - 0.00016 21.0 0.1 0.07 12.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EDK41699.2 - 0.0017 18.2 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 EDK41699.2 - 0.002 18.3 0.0 0.006 16.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EDK41699.2 - 0.0021 17.4 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EDK41699.2 - 0.0026 17.2 0.1 0.34 10.2 0.0 3.0 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EDK41699.2 - 0.0047 16.9 0.3 1.8 8.6 0.3 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EDK41699.2 - 0.0066 15.7 0.0 0.014 14.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EDK41699.2 - 0.0079 15.8 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EDK41699.2 - 0.029 14.9 0.0 0.082 13.5 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TPMT PF05724.11 EDK41699.2 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MFS_1 PF07690.16 EDK41700.2 - 2.8e-33 115.3 28.7 3.6e-33 114.9 28.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EDK41700.2 - 2e-06 27.4 17.1 1e-05 25.1 17.1 2.0 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB FAD_binding_6 PF00970.24 EDK41701.2 - 5.1e-11 42.8 0.0 1.1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.22 EDK41701.2 - 1.1e-09 38.8 0.0 2.8e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 EDK41701.2 - 2.9e-07 31.1 0.0 1.6e-06 28.8 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.8 EDK41701.2 - 0.077 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protoglobin NAD_binding_6 PF08030.12 EDK41701.2 - 0.096 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Epimerase PF01370.21 EDK41702.1 - 3.2e-18 66.1 0.1 4.7e-18 65.5 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41702.1 - 7.4e-15 54.7 0.1 9.9e-15 54.3 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EDK41702.1 - 5e-11 42.2 0.1 4.3e-05 22.8 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EDK41702.1 - 1e-10 41.8 0.5 2.2e-10 40.7 0.4 1.8 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDK41702.1 - 2.2e-05 24.1 0.9 0.0047 16.5 0.3 2.2 2 0 0 2 2 2 2 NmrA-like family RmlD_sub_bind PF04321.17 EDK41702.1 - 0.00023 20.4 0.1 0.017 14.3 0.0 2.2 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EDK41702.1 - 0.00035 20.1 0.5 0.0016 17.9 0.2 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDK41702.1 - 0.00069 18.8 0.4 0.0015 17.7 0.4 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDK41702.1 - 0.0043 16.5 0.1 0.0069 15.9 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase F420_oxidored PF03807.17 EDK41702.1 - 0.0046 17.5 0.0 0.012 16.2 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 EDK41702.1 - 0.06 13.2 0.1 0.14 12.1 0.1 1.6 1 1 0 1 1 1 0 KR domain Shikimate_DH PF01488.20 EDK41702.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 EDK41702.1 - 0.11 12.7 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus SERTA PF06031.13 EDK41704.2 - 0.17 11.6 0.7 0.3 10.8 0.7 1.4 1 0 0 1 1 1 0 SERTA motif DcuC PF03606.15 EDK41705.2 - 0.014 13.9 1.3 0.021 13.3 1.3 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Hanta_nucleocap PF00846.18 EDK41705.2 - 0.14 10.6 0.0 0.22 9.9 0.0 1.2 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein Abhydrolase_1 PF00561.20 EDK41706.2 - 1.4e-24 87.1 0.0 1.8e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDK41706.2 - 1.1e-17 65.4 0.0 1.3e-17 65.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK41706.2 - 7.8e-11 41.7 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDK41706.2 - 0.00019 21.7 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EDK41706.2 - 0.0024 17.6 0.0 1.4 8.6 0.1 2.3 1 1 1 2 2 2 2 PGAP1-like protein Esterase PF00756.20 EDK41706.2 - 0.0032 17.1 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Putative esterase DUF676 PF05057.14 EDK41706.2 - 0.049 13.1 0.0 0.092 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF1057 PF06342.12 EDK41706.2 - 0.14 11.2 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) CN_hydrolase PF00795.22 EDK41707.2 - 4.2e-54 183.6 0.0 4.8e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase YoaP PF14268.6 EDK41707.2 - 0.18 11.4 0.2 0.33 10.5 0.2 1.4 1 0 0 1 1 1 0 YoaP-like MFS_1 PF07690.16 EDK41708.2 - 3.1e-36 125.0 44.0 1e-35 123.3 42.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Mannosyl_trans3 PF11051.8 EDK41709.2 - 1.1e-81 274.2 0.0 1.7e-81 273.6 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Sas10 PF09368.10 EDK41709.2 - 0.021 15.3 0.2 0.061 13.8 0.2 1.7 1 0 0 1 1 1 0 Sas10 C-terminal domain UPF0061 PF02696.14 EDK41710.2 - 7.6e-126 420.6 0.2 9.3e-126 420.3 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Bul1_N PF04425.12 EDK41712.2 - 2.6e-127 425.3 10.1 5.1e-127 424.4 10.1 1.4 1 0 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.12 EDK41712.2 - 9.5e-16 58.0 12.8 4.9e-08 32.7 0.7 3.3 2 1 1 3 3 3 2 Bul1 C terminus Transp_cyt_pur PF02133.15 EDK41713.2 - 6.3e-10 38.4 41.6 3.3e-09 36.0 41.6 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Zn_clus PF00172.18 EDK41714.2 - 3.5e-05 23.8 10.4 5.9e-05 23.1 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mannosyl_trans3 PF11051.8 EDK41715.2 - 3.2e-86 289.1 0.4 3.2e-86 289.1 0.4 2.1 2 0 0 2 2 2 1 Mannosyltransferase putative Amidase PF01425.21 EDK41716.2 - 2.5e-89 300.3 0.0 3.1e-89 300.0 0.0 1.1 1 0 0 1 1 1 1 Amidase GTP_EFTU PF00009.27 EDK41717.2 - 2.7e-43 147.8 0.2 4e-43 147.2 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDK41717.2 - 1.6e-06 28.4 0.3 6e-06 26.5 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EDK41717.2 - 3.8e-06 27.0 0.3 0.00017 21.6 0.1 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDK41717.2 - 0.0022 18.4 0.0 0.006 16.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.10 EDK41717.2 - 0.004 16.6 0.2 0.2 11.1 0.1 2.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDK41717.2 - 0.028 14.6 0.2 3.1 8.0 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Syntaxin-18_N PF10496.9 EDK41718.2 - 3.7e-09 36.7 1.6 1.4e-08 34.8 0.0 2.7 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus DUF848 PF05852.11 EDK41718.2 - 0.12 12.5 11.8 0.066 13.3 3.7 2.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Methyltransf_3 PF01596.17 EDK41719.2 - 3.7e-20 72.0 0.0 4.7e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EDK41719.2 - 4.7e-13 50.1 0.0 6.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EDK41719.2 - 0.076 12.7 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Cephalosporin hydroxylase SYF2 PF08231.12 EDK41720.2 - 1.6e-14 54.6 24.0 1.6e-14 54.6 24.0 2.4 1 1 1 2 2 2 1 SYF2 splicing factor SH2_2 PF14633.6 EDK41721.2 - 4.6e-72 241.9 0.3 4.6e-72 241.9 0.3 2.7 3 0 0 3 3 3 1 SH2 domain HTH_44 PF14641.6 EDK41721.2 - 2.7e-36 124.5 3.9 2.7e-36 124.5 3.9 2.4 3 0 0 3 3 3 1 Helix-turn-helix DNA-binding domain of SPT6 YqgF PF14639.6 EDK41721.2 - 1.8e-35 121.9 0.0 5.4e-35 120.4 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 EDK41721.2 - 1.5e-29 102.4 0.1 4.2e-29 101.0 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif SPT6_acidic PF14632.6 EDK41721.2 - 1.3e-17 64.2 20.6 1.3e-17 64.2 20.6 5.4 5 0 0 5 5 5 2 Acidic N-terminal SPT6 HHH_9 PF17674.1 EDK41721.2 - 1.6e-06 28.9 2.7 3.3e-05 24.7 0.4 3.8 2 1 0 2 2 2 1 HHH domain Phospho_p8 PF10195.9 EDK41721.2 - 0.0079 16.7 0.7 0.028 14.9 0.7 2.0 1 0 0 1 1 1 1 DNA-binding nuclear phosphoprotein p8 TauD PF02668.16 EDK41722.2 - 1e-46 159.9 0.0 1.4e-46 159.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EDK41722.2 - 1.9e-05 25.2 0.1 8.5e-05 23.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 EDK41722.2 - 0.059 12.5 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 CsiD ThrE PF06738.12 EDK41723.2 - 6.2e-65 218.9 18.1 4.5e-64 216.1 6.4 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EDK41723.2 - 6.7e-09 36.0 8.3 6.7e-09 36.0 8.3 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE PDCD2_C PF04194.13 EDK41724.2 - 4e-39 134.5 0.1 2.9e-35 121.9 0.0 3.0 3 0 0 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain GTP_EFTU PF00009.27 EDK41725.2 - 1e-32 113.3 8.5 5.9e-32 110.8 5.1 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDK41725.2 - 3.8e-28 97.7 0.7 1.2e-27 96.1 0.7 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 IF2_N PF04760.15 EDK41725.2 - 1.2e-11 44.3 0.0 5.6e-11 42.1 0.0 2.3 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 EDK41725.2 - 4.9e-09 36.3 0.3 1.7e-08 34.5 0.3 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EDK41725.2 - 0.0003 21.1 0.6 0.025 15.0 0.1 3.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Arf PF00025.21 EDK41725.2 - 0.0018 17.8 0.7 0.0031 17.0 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 EDK41725.2 - 0.0028 17.3 0.2 0.0064 16.1 0.2 1.6 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDK41725.2 - 0.0059 16.0 0.3 0.0059 16.0 0.3 2.3 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDK41725.2 - 0.0062 16.8 0.9 0.021 15.0 0.1 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 EDK41725.2 - 0.0093 15.9 1.4 0.039 13.9 0.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Hydrolase_6 PF13344.6 EDK41725.2 - 0.013 15.6 0.1 2.6 8.2 0.0 3.7 3 2 0 3 3 3 0 Haloacid dehalogenase-like hydrolase MMR_HSR1_Xtn PF16897.5 EDK41725.2 - 0.056 13.5 0.3 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain PMD PF10536.9 EDK41725.2 - 0.099 11.7 0.3 0.27 10.3 0.0 1.7 2 0 0 2 2 2 0 Plant mobile domain Dynamin_N PF00350.23 EDK41725.2 - 1.7 8.6 6.9 14 5.7 0.0 3.6 3 1 1 4 4 4 0 Dynamin family Dfp1_Him1_M PF08630.10 EDK41726.2 - 2.7e-37 127.8 0.1 8.3e-37 126.2 0.0 1.9 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EDK41726.2 - 2.2e-21 75.7 0.8 4.2e-21 74.8 0.8 1.5 1 0 0 1 1 1 1 DBF zinc finger UQ_con PF00179.26 EDK41728.2 - 2.8e-40 137.2 0.0 3.5e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDK41728.2 - 0.0049 16.6 0.0 0.015 15.0 0.0 1.7 1 1 0 1 1 1 1 Prokaryotic E2 family B SH3BGR PF04908.15 EDK41729.2 - 1.8e-07 31.2 1.1 2.5e-06 27.6 0.0 3.3 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EDK41729.2 - 0.016 15.4 0.1 0.088 13.0 0.0 2.3 2 0 0 2 2 2 0 Glutaredoxin Drf_GBD PF06371.13 EDK41729.2 - 0.081 12.5 0.2 0.34 10.4 0.2 2.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain KH_1 PF00013.29 EDK41730.2 - 2.7e-75 248.1 38.1 6.7e-11 41.9 0.0 12.5 13 0 0 13 13 13 9 KH domain KH_4 PF13083.6 EDK41730.2 - 1e-05 25.3 2.2 9.9 6.1 0.0 5.7 4 1 0 4 4 4 3 KH domain KH_2 PF07650.17 EDK41730.2 - 0.004 16.9 15.5 3.8 7.4 0.0 6.6 7 0 0 7 7 7 2 KH domain DUF45 PF01863.17 EDK41730.2 - 0.099 12.7 0.2 0.55 10.2 0.2 2.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 FAD_binding_7 PF03441.14 EDK41731.2 - 1.4e-77 259.8 0.9 1.4e-77 259.8 0.9 1.6 2 0 0 2 2 2 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EDK41731.2 - 3.2e-35 121.6 0.1 6e-35 120.7 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase WIYLD PF10440.9 EDK41731.2 - 0.13 12.1 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain AA_permease_2 PF13520.6 EDK41732.2 - 1e-90 304.6 42.6 1.3e-90 304.3 42.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDK41732.2 - 2.2e-16 59.5 38.0 2.8e-16 59.2 38.0 1.1 1 0 0 1 1 1 1 Amino acid permease L51_S25_CI-B8 PF05047.16 EDK41733.2 - 4e-06 26.7 0.0 6.7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Zn_clus PF00172.18 EDK41734.2 - 0.0031 17.6 13.6 0.0031 17.6 13.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TauD PF02668.16 EDK41735.1 - 1.5e-58 198.7 1.3 2.1e-58 198.2 1.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TauD PF02668.16 EDK41736.1 - 1.4e-58 198.8 1.3 2e-58 198.3 1.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family EF-hand_4 PF12763.7 EDK41737.2 - 1.2e-25 89.5 0.0 1.4e-11 44.3 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 EDK41737.2 - 1.1e-10 41.2 0.6 2.4e-10 40.1 0.6 1.6 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.32 EDK41737.2 - 0.0008 18.8 0.0 0.52 10.0 0.0 3.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EDK41737.2 - 0.0009 19.0 0.0 0.072 13.1 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain DUF4201 PF13870.6 EDK41737.2 - 0.0038 17.0 20.8 0.0038 17.0 20.8 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) UBA_4 PF14555.6 EDK41737.2 - 0.004 16.9 0.3 0.0089 15.8 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain TPR_MLP1_2 PF07926.12 EDK41737.2 - 0.0044 17.1 26.2 0.0044 17.1 26.2 3.3 1 1 2 3 3 2 1 TPR/MLP1/MLP2-like protein DUF2968 PF11180.8 EDK41737.2 - 0.0051 16.5 6.6 0.0051 16.5 6.6 3.5 1 1 1 3 3 3 1 Protein of unknown function (DUF2968) Filament PF00038.21 EDK41737.2 - 0.013 15.1 38.0 0.024 14.2 38.0 1.3 1 0 0 1 1 1 0 Intermediate filament protein DUF3584 PF12128.8 EDK41737.2 - 0.1 10.1 38.6 0.17 9.3 38.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) EF-hand_7 PF13499.6 EDK41737.2 - 0.11 13.0 0.0 0.72 10.4 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain pair MADF_DNA_bdg PF10545.9 EDK41737.2 - 0.18 12.1 6.8 0.1 12.9 2.6 2.5 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Prok-TraM PF09228.10 EDK41737.2 - 1.6 9.2 11.7 0.79 10.1 3.5 3.0 2 1 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM COG2 PF06148.11 EDK41737.2 - 3.2 7.8 22.2 0.36 10.9 4.6 3.1 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CbtA PF09490.10 EDK41737.2 - 4.6 6.9 6.5 0.4 10.4 1.4 1.8 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) PI_PP_I PF18363.1 EDK41737.2 - 6.2 7.1 6.2 24 5.2 0.7 2.8 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain Gar1 PF04410.14 EDK41738.2 - 1.3e-40 138.7 0.0 1.6e-40 138.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region MMR_HSR1 PF01926.23 EDK41739.2 - 3.3e-19 69.1 0.0 5.6e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDK41739.2 - 2.7e-07 30.3 0.2 4e-05 23.2 0.2 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDK41739.2 - 1.6e-06 28.2 0.1 8.7e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EDK41739.2 - 1.7e-06 27.6 0.0 3.7e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EDK41739.2 - 9.2e-06 25.3 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDK41739.2 - 1e-05 25.6 0.1 0.13 12.3 0.2 2.5 1 1 1 2 2 2 2 Dynamin family AAA_22 PF13401.6 EDK41739.2 - 0.036 14.4 0.0 0.081 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.16 EDK41739.2 - 0.039 13.3 0.0 0.058 12.7 0.0 1.4 1 0 0 1 1 1 0 AIG1 family PLDc PF00614.22 EDK41740.2 - 1.1e-16 60.3 0.1 5.5e-08 32.7 0.1 2.9 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EDK41740.2 - 3.7e-13 49.5 1.9 1.9e-07 31.0 0.1 3.3 3 1 0 3 3 3 2 PLD-like domain PH PF00169.29 EDK41740.2 - 0.16 12.5 0.5 0.56 10.7 0.5 2.0 1 1 0 1 1 1 0 PH domain Erv26 PF04148.13 EDK41741.2 - 3.1e-78 262.3 9.8 4.3e-78 261.9 9.8 1.2 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 CD20 PF04103.15 EDK41741.2 - 0.031 14.3 1.7 0.031 14.3 1.7 2.0 2 0 0 2 2 2 0 CD20-like family DUF996 PF06195.13 EDK41741.2 - 0.038 14.3 4.7 0.085 13.1 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF996) DHHC PF01529.20 EDK41741.2 - 2.2 8.4 9.6 0.39 10.8 3.1 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase YtpI PF14007.6 EDK41741.2 - 2.6 8.3 7.8 3.4 7.9 2.8 2.7 1 1 2 3 3 3 0 YtpI-like protein Yip1 PF04893.17 EDK41741.2 - 3.2 7.5 12.4 0.38 10.4 7.0 2.0 1 1 1 2 2 2 0 Yip1 domain Abhydrolase_1 PF00561.20 EDK41742.2 - 1.3e-45 156.1 0.0 2.2e-45 155.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EDK41742.2 - 2.4e-05 24.1 0.0 4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 EDK41742.2 - 0.014 16.1 0.0 0.018 15.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDK41742.2 - 0.13 11.5 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EDK41742.2 - 0.14 11.6 0.0 2.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Scs3p PF10261.9 EDK41743.2 - 4.2e-28 98.5 8.3 1.3e-27 96.8 8.3 1.7 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM HMA PF00403.26 EDK41744.1 - 3.8e-06 27.3 8.4 0.00076 19.9 0.3 3.2 4 0 0 4 4 4 2 Heavy-metal-associated domain RRP36 PF06102.12 EDK41744.1 - 0.05 13.6 0.5 0.095 12.7 0.0 1.6 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 E1-E2_ATPase PF00122.20 EDK41745.2 - 2.8e-47 160.6 0.6 1.8e-46 158.0 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EDK41745.2 - 4.5e-34 118.6 0.0 6.6e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDK41745.2 - 0.00021 21.7 0.0 0.00053 20.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDK41745.2 - 0.011 15.5 0.1 0.078 12.7 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4342 PF14242.6 EDK41745.2 - 0.3 11.1 5.0 3.3 7.8 0.0 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4342) PP2C PF00481.21 EDK41746.2 - 1.2e-63 215.2 0.5 8.7e-50 169.7 0.2 2.5 2 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EDK41746.2 - 0.0021 18.0 0.0 0.004 17.1 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) UPF0029 PF01205.19 EDK41746.2 - 0.13 12.6 0.1 0.28 11.5 0.1 1.8 1 1 0 1 1 1 0 Uncharacterized protein family UPF0029 F-box-like PF12937.7 EDK41747.2 - 0.0017 18.2 0.1 0.0045 16.8 0.1 1.8 1 0 0 1 1 1 1 F-box-like Hydrolase_4 PF12146.8 EDK41748.2 - 6.4e-21 74.7 0.0 7.3e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDK41748.2 - 0.0032 17.1 0.0 0.36 10.4 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold PIG-H PF10181.9 EDK41748.2 - 0.15 12.0 0.1 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 GPI-GlcNAc transferase complex, PIG-H component DDE_1 PF03184.19 EDK41749.2 - 4.2e-30 104.7 1.6 1.3e-29 103.0 0.6 2.3 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EDK41749.2 - 1.4e-16 60.3 0.1 3.2e-16 59.1 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 EDK41749.2 - 1.3e-06 28.0 0.3 4.3e-06 26.3 0.3 1.8 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain Pet100 PF09803.9 EDK41750.2 - 0.14 12.7 0.3 0.18 12.3 0.3 1.1 1 0 0 1 1 1 0 Pet100 DUF846 PF05832.12 EDK41751.2 - 4.3e-52 175.8 12.0 5.2e-52 175.6 12.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Clathrin PF00637.20 EDK41752.2 - 1.6e-29 102.6 6.9 2.1e-29 102.3 2.2 3.2 4 0 0 4 4 4 1 Region in Clathrin and VPS WD40 PF00400.32 EDK41752.2 - 0.007 17.2 0.3 0.057 14.3 0.1 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat APOBEC2 PF18772.1 EDK41752.2 - 0.0091 16.1 0.1 0.018 15.1 0.1 1.4 1 0 0 1 1 1 1 APOBEC2 TPR_19 PF14559.6 EDK41752.2 - 0.042 14.4 0.1 21 5.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EDK41752.2 - 0.059 13.6 0.3 0.31 11.3 0.3 2.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 Tfb5 PF06331.12 EDK41753.1 - 5e-22 77.7 0.0 5.5e-22 77.5 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Sec34 PF04136.15 EDK41754.2 - 1.3e-44 151.7 2.7 1.3e-44 151.7 2.7 3.1 3 0 0 3 3 3 1 Sec34-like family ANAPC4 PF12896.7 EDK41754.2 - 0.013 15.0 0.2 8.1 5.9 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Dor1 PF04124.12 EDK41754.2 - 0.018 13.8 7.1 0.021 13.5 3.3 2.6 2 1 0 2 2 2 0 Dor1-like family TraG_N PF07916.11 EDK41754.2 - 0.035 12.9 0.3 0.083 11.7 0.1 1.7 2 0 0 2 2 2 0 TraG-like protein, N-terminal region CPSase_L_D3 PF02787.19 EDK41754.2 - 0.061 13.7 0.7 0.49 10.8 0.2 2.6 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain zf-primase PF09329.11 EDK41755.2 - 1.8e-07 30.8 3.1 3.5e-07 29.9 3.1 1.5 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 EDK41755.2 - 0.046 13.7 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF3810 PF12725.7 EDK41756.2 - 0.089 12.1 0.1 0.099 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) GRAM PF02893.20 EDK41756.2 - 0.092 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 GRAM domain p450 PF00067.22 EDK41757.1 - 6.9e-65 219.6 0.0 8.9e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UPF0160 PF03690.13 EDK41758.2 - 6.6e-131 436.7 0.0 7.6e-131 436.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) MFS_1 PF07690.16 EDK41759.2 - 7.2e-14 51.5 7.9 7.2e-14 51.5 7.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1673 PF07895.11 EDK41759.2 - 0.11 12.2 6.6 0.23 11.2 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF1700 PF08006.11 EDK41759.2 - 0.83 9.2 7.5 0.11 12.0 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1700) Trep_Strep PF09605.10 EDK41759.2 - 3.8 7.4 11.5 2.6 8.0 5.9 2.9 1 1 2 3 3 3 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Sugar_tr PF00083.24 EDK41761.1 - 2.1e-108 363.1 33.5 2.5e-108 362.8 33.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41761.1 - 6.3e-22 78.0 38.5 1.4e-21 76.8 34.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDK41762.1 - 8.6e-111 371.0 25.3 1.1e-110 370.7 25.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDK41762.1 - 7.6e-26 90.9 27.9 1.5e-25 89.9 24.4 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 EDK41762.1 - 0.064 13.8 0.6 0.17 12.4 0.6 1.7 1 0 0 1 1 1 0 Phage holin family 2 Pkinase PF00069.25 EDK41763.2 - 1.9e-37 129.0 0.0 2.4e-24 86.1 0.0 3.1 2 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDK41763.2 - 3.2e-15 56.1 0.0 3.2e-12 46.3 0.0 3.1 1 1 1 2 2 2 1 Protein tyrosine kinase NotI PF12183.8 EDK41763.2 - 0.0026 17.2 0.6 0.0067 15.8 0.4 1.7 2 0 0 2 2 2 1 Restriction endonuclease NotI Pox_ser-thr_kin PF05445.11 EDK41763.2 - 0.022 13.8 0.0 0.042 12.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EDK41763.2 - 0.1 12.5 0.0 0.41 10.5 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family GalKase_gal_bdg PF10509.9 EDK41764.2 - 2.9e-22 78.0 0.0 5.5e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EDK41764.2 - 8.4e-15 54.8 0.3 2e-14 53.5 0.3 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDK41764.2 - 2.3e-10 40.7 0.0 4.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Aldose_epim PF01263.20 EDK41765.1 - 3.3e-66 223.6 0.4 4.7e-66 223.1 0.4 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase GDP_Man_Dehyd PF16363.5 EDK41765.1 - 6.2e-52 177.0 0.0 8.6e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDK41765.1 - 8.1e-50 169.5 0.0 1.1e-49 169.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDK41765.1 - 1.3e-17 63.7 0.2 4.1e-17 62.1 0.2 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EDK41765.1 - 4.1e-17 62.2 0.1 2.7e-15 56.3 0.1 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EDK41765.1 - 1.1e-10 41.2 0.0 2.1e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EDK41765.1 - 5.4e-08 32.3 0.0 1.7e-05 24.1 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein KR PF08659.10 EDK41765.1 - 3.5e-06 27.1 0.0 6.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EDK41765.1 - 1.1e-05 25.0 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EDK41765.1 - 1.9e-05 24.7 0.0 3.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDK41765.1 - 0.00089 18.9 0.3 0.002 17.7 0.3 1.6 1 0 0 1 1 1 1 NmrA-like family UDPG_MGDP_dh_N PF03721.14 EDK41765.1 - 0.018 14.6 0.1 0.057 13.0 0.2 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain bZIP_C PF12498.8 EDK41765.1 - 0.14 13.2 0.0 0.32 12.0 0.0 1.6 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Sybindin PF04099.12 EDK41766.1 - 8e-37 126.3 2.0 4.1e-23 81.9 0.1 2.2 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 EDK41766.1 - 1.5e-08 34.9 0.2 2.1e-08 34.4 0.2 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region GDP_Man_Dehyd PF16363.5 EDK41767.2 - 9.1e-76 255.4 0.0 1e-75 255.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDK41767.2 - 1.3e-51 175.4 0.0 1.6e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EDK41767.2 - 5.6e-15 55.2 0.0 2e-14 53.4 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EDK41767.2 - 1e-10 41.2 0.0 1.6e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EDK41767.2 - 4.1e-10 39.1 0.0 5.8e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EDK41767.2 - 1.5e-08 34.2 0.0 2.6e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDK41767.2 - 0.0085 15.6 0.0 0.76 9.2 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 EDK41767.2 - 0.1 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GalP_UDP_transf PF01087.22 EDK41768.2 - 6.4e-67 225.6 0.1 1.1e-66 224.7 0.1 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EDK41768.2 - 3.8e-65 218.7 0.7 7.2e-65 217.8 0.7 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 EDK41768.2 - 3.4e-06 26.1 1.1 0.0028 16.5 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) DcpS_C PF11969.8 EDK41768.2 - 0.071 13.6 0.7 0.15 12.6 0.7 1.6 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Methyltransf_23 PF13489.6 EDK41769.2 - 1.3e-19 70.7 0.0 1.8e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDK41769.2 - 8.1e-15 55.4 0.1 5.7e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDK41769.2 - 3.9e-13 49.9 0.0 9.2e-13 48.7 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDK41769.2 - 1.2e-09 38.7 0.0 2.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDK41769.2 - 5.9e-08 32.7 0.0 1.4e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDK41769.2 - 0.00018 20.8 0.0 0.46 9.6 0.0 2.2 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family Pox_MCEL PF03291.16 EDK41769.2 - 0.0055 15.8 0.0 0.041 13.0 0.0 2.3 1 1 0 1 1 1 1 mRNA capping enzyme CMAS PF02353.20 EDK41769.2 - 0.0056 16.0 0.1 0.02 14.2 0.0 1.9 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase RRM_1 PF00076.22 EDK41769.2 - 0.0058 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CheR PF01739.18 EDK41769.2 - 0.0069 15.9 0.0 2.1 7.8 0.0 2.3 2 0 0 2 2 2 2 CheR methyltransferase, SAM binding domain MTS PF05175.14 EDK41769.2 - 0.037 13.6 0.0 0.094 12.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EDK41769.2 - 0.14 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EDK41769.2 - 0.17 11.9 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cullin PF00888.22 EDK41770.2 - 1.2e-150 503.2 3.7 1.5e-150 502.8 3.7 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDK41770.2 - 2.4e-25 88.3 2.4 2.4e-25 88.3 2.4 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain Penicillinase_R PF03965.16 EDK41770.2 - 0.12 12.7 0.1 0.46 10.8 0.1 2.1 1 0 0 1 1 1 0 Penicillinase repressor SANT_DAMP1_like PF16282.5 EDK41772.2 - 2.6e-16 59.6 0.6 3.9e-14 52.6 0.1 2.6 2 0 0 2 2 2 2 SANT/Myb-like domain of DAMP1 TerB PF05099.13 EDK41772.2 - 1.2 9.1 0.0 1.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Tellurite resistance protein TerB Mus7 PF09462.10 EDK41773.2 - 1e-34 120.5 19.0 2.9e-23 82.6 1.3 3.4 3 1 0 4 4 4 2 Mus7/MMS22 family 3Beta_HSD PF01073.19 EDK41775.2 - 2.2e-85 286.1 0.0 2.6e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDK41775.2 - 7.6e-30 104.1 0.0 9.4e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDK41775.2 - 3.9e-19 69.2 0.0 1e-18 67.9 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDK41775.2 - 4.5e-15 55.5 0.0 5.8e-14 51.9 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDK41775.2 - 1.9e-13 50.7 0.0 3.6e-13 49.8 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EDK41775.2 - 3.2e-10 39.6 0.0 4.6e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDK41775.2 - 3.1e-08 33.1 0.0 1.1e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EDK41775.2 - 0.00038 20.1 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EDK41775.2 - 0.0069 16.3 0.0 0.07 13.0 0.0 2.2 1 1 0 1 1 1 1 KR domain Methyltransf_2 PF00891.18 EDK41775.2 - 0.032 13.5 0.0 0.35 10.1 0.0 2.2 2 0 0 2 2 2 0 O-methyltransferase domain Semialdhyde_dh PF01118.24 EDK41775.2 - 0.076 13.4 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain FtsJ PF01728.19 EDK41775.2 - 0.13 12.4 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DB PF01682.19 EDK41776.2 - 0.024 14.9 7.7 0.039 14.2 7.7 1.4 1 0 0 1 1 1 0 DB module Glyco_hydro_72 PF03198.14 EDK41777.2 - 2.1e-136 454.3 11.6 2.8e-136 453.9 11.6 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EDK41777.2 - 1e-27 96.6 5.8 3.4e-27 95.0 5.8 2.0 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 EDK41777.2 - 9.6e-05 21.6 2.2 0.00041 19.6 2.2 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain G-patch PF01585.23 EDK41778.2 - 1.8e-11 43.7 0.1 6.9e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EDK41778.2 - 0.0027 17.8 0.0 0.0027 17.8 0.0 3.4 2 1 0 2 2 1 1 G-patch domain RR_TM4-6 PF06459.12 EDK41778.2 - 0.017 15.0 23.9 0.022 14.6 23.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 EDK41778.2 - 0.045 14.0 17.0 0.072 13.4 17.0 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family FeoA PF04023.14 EDK41778.2 - 0.088 13.1 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 FeoA domain SRP-alpha_N PF04086.13 EDK41778.2 - 0.15 11.9 26.8 0.22 11.4 26.8 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SET PF00856.28 EDK41778.2 - 0.27 11.6 6.6 0.43 11.0 6.6 1.3 1 0 0 1 1 1 0 SET domain CDC45 PF02724.14 EDK41778.2 - 0.35 9.1 22.6 0.44 8.8 22.6 1.1 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 EDK41778.2 - 0.63 7.1 10.9 0.59 7.2 10.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 EDK41778.2 - 0.96 9.5 12.2 1.3 9.0 12.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 EDK41778.2 - 1.7 7.6 10.0 2.3 7.1 10.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4775 PF16001.5 EDK41778.2 - 2.3 7.6 34.1 3.1 7.1 34.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) SOBP PF15279.6 EDK41778.2 - 3.2 8.3 14.1 4 8.0 14.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.7 EDK41778.2 - 6 4.9 18.8 6.9 4.7 18.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 EDK41778.2 - 9.5 5.1 21.2 12 4.8 21.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 N6-adenineMlase PF10237.9 EDK41779.2 - 1.5e-50 171.1 0.1 2.1e-50 170.7 0.1 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase B-block_TFIIIC PF04182.12 EDK41780.2 - 7.7e-22 77.2 0.0 2.5e-20 72.4 0.0 3.1 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 EDK41780.2 - 0.0004 20.2 0.0 0.0036 17.1 0.0 2.3 2 0 0 2 2 2 1 MarR family MarR PF01047.22 EDK41780.2 - 0.028 14.4 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 MarR family Rpn9_C PF18261.1 EDK41780.2 - 0.045 13.4 0.6 0.14 11.8 0.6 1.8 1 0 0 1 1 1 0 Rpn9 C-terminal helix HTH_20 PF12840.7 EDK41780.2 - 0.15 12.1 0.0 0.66 10.1 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain SNF5 PF04855.12 EDK41781.2 - 2.1e-50 171.7 0.6 1.6e-46 159.0 0.6 2.3 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 FlgM PF04316.13 EDK41781.2 - 0.64 10.4 0.0 0.64 10.4 0.0 2.4 3 0 0 3 3 3 0 Anti-sigma-28 factor, FlgM dCMP_cyt_deam_1 PF00383.23 EDK41782.2 - 2.9e-07 30.3 0.1 5.5e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDK41782.2 - 0.00075 19.3 1.7 0.0042 16.8 1.7 2.2 1 1 0 1 1 1 1 MafB19-like deaminase APOBEC2 PF18772.1 EDK41782.2 - 0.072 13.1 0.2 2.6 8.0 0.1 2.4 2 0 0 2 2 2 0 APOBEC2 KIAA1430 PF13879.6 EDK41782.2 - 0.081 13.7 0.4 0.081 13.7 0.4 2.5 3 0 0 3 3 3 0 KIAA1430 homologue Telomerase_RBD PF12009.8 EDK41783.2 - 3.3e-28 98.5 0.5 9.3e-27 93.8 0.2 2.7 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EDK41783.2 - 4.5e-12 46.0 0.4 7.9e-09 35.4 0.1 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) AIP3 PF03915.13 EDK41784.2 - 1.9e-128 429.0 19.7 1.9e-128 429.0 19.7 2.0 3 0 0 3 3 3 1 Actin interacting protein 3 DUF1640 PF07798.11 EDK41784.2 - 0.00031 20.9 1.4 0.00031 20.9 1.4 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1640) E2R135 PF11570.8 EDK41784.2 - 0.024 14.9 1.6 0.075 13.3 0.4 2.4 2 0 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 CorA PF01544.18 EDK41784.2 - 2.1 7.6 8.5 0.35 10.1 3.6 2.2 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein Importin_rep_5 PF18816.1 EDK41785.2 - 3e-21 75.5 0.1 5.8e-21 74.5 0.1 1.5 1 0 0 1 1 1 1 Importin repeat HEAT PF02985.22 EDK41785.2 - 0.0037 17.4 0.4 0.13 12.5 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat DUF2277 PF10041.9 EDK41785.2 - 0.17 12.2 0.6 3.2 8.2 0.0 2.7 2 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2277) Importin_rep_6 PF18829.1 EDK41786.1 - 5.5e-31 106.9 1.9 5.5e-31 106.9 1.9 1.7 2 0 0 2 2 2 1 Importin repeat 6 Importin_rep_4 PF18808.1 EDK41787.2 - 2.5e-29 101.4 2.4 8.4e-29 99.7 0.7 2.7 3 0 0 3 3 3 1 Importin repeat HEAT PF02985.22 EDK41787.2 - 0.00011 22.1 0.5 2.1 8.8 0.1 4.5 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 EDK41787.2 - 0.0045 17.5 0.0 0.18 12.3 0.0 3.2 1 1 1 2 2 2 1 HEAT-like repeat DRIM PF07539.12 EDK41787.2 - 0.038 12.3 0.7 0.13 10.6 0.3 1.9 2 0 0 2 2 2 0 Down-regulated in metastasis FANCI_S1 PF14675.6 EDK41787.2 - 0.083 12.5 0.0 0.39 10.2 0.0 2.0 2 1 0 2 2 2 0 FANCI solenoid 1 ParcG PF10274.9 EDK41787.2 - 0.1 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Parkin co-regulated protein Herpes_HEPA PF03324.14 EDK41787.2 - 0.15 12.5 0.0 0.47 11.0 0.0 1.8 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein MMR_HSR1_Xtn PF16897.5 EDK41788.1 - 5.9e-39 132.4 0.2 2e-38 130.6 0.1 1.9 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EDK41788.1 - 1.5e-22 79.4 0.0 3e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EDK41788.1 - 4e-21 75.2 0.4 1.7e-20 73.2 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDK41788.1 - 2.1e-09 37.1 0.0 4.5e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDK41788.1 - 0.0042 17.2 0.5 3 7.9 0.0 2.4 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EDK41788.1 - 0.01 14.9 0.2 0.022 13.8 0.2 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 EDK41788.1 - 0.11 11.9 0.2 1.6 8.2 0.1 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_22 PF13401.6 EDK41788.1 - 0.13 12.6 0.1 8.6 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDK41788.1 - 0.15 11.9 0.7 3.1 7.7 0.0 2.9 2 1 1 3 3 3 0 RsgA GTPase GTP_EFTU PF00009.27 EDK41789.2 - 2.2e-33 115.4 0.0 2.2e-33 115.4 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDK41789.2 - 1.5e-20 73.3 0.3 6.6e-20 71.2 0.0 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EDK41789.2 - 1.7e-12 47.6 0.6 2.8e-08 34.0 0.0 3.3 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDK41789.2 - 2.2e-07 31.0 0.1 7.3e-06 26.1 0.0 3.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDK41789.2 - 1.5e-06 28.0 0.1 6.8e-06 25.9 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Roc PF08477.13 EDK41789.2 - 0.0002 21.6 0.0 0.0007 19.8 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EDK41789.2 - 0.0017 18.4 0.4 0.0017 18.4 0.4 4.1 4 0 0 4 4 4 1 Dynamin family RsgA_GTPase PF03193.16 EDK41789.2 - 0.086 12.7 0.2 0.086 12.7 0.2 2.9 3 1 0 3 3 3 0 RsgA GTPase AAA_22 PF13401.6 EDK41789.2 - 0.2 12.0 1.9 1 9.6 0.4 3.0 2 1 0 2 2 2 0 AAA domain ERM PF00769.19 EDK41789.2 - 1.4 8.7 84.6 0.19 11.6 32.5 3.5 3 0 0 3 3 3 0 Ezrin/radixin/moesin family Hydrolase_6 PF13344.6 EDK41790.2 - 1.2e-27 96.0 0.0 2.5e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDK41790.2 - 1.4e-16 60.3 0.0 2.6e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDK41790.2 - 2.4e-07 31.3 0.0 3.8e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDK41790.2 - 0.052 13.6 0.9 0.38 10.8 0.0 2.4 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Hpt PF01627.23 EDK41791.1 - 2.4e-09 37.3 0.1 7.3e-09 35.8 0.1 1.8 1 1 1 2 2 2 1 Hpt domain Carb_anhydrase PF00194.21 EDK41791.1 - 0.086 12.4 0.0 0.2 11.1 0.0 1.6 1 1 1 2 2 2 0 Eukaryotic-type carbonic anhydrase CitX PF03802.14 EDK41791.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Glyco_transf_22 PF03901.17 EDK41792.2 - 3.1e-80 270.5 28.6 3.9e-80 270.1 28.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AA_permease PF00324.21 EDK41793.2 - 7.5e-133 443.6 48.0 8.6e-133 443.4 48.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDK41793.2 - 2.1e-37 129.0 49.3 2.5e-37 128.7 49.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF98 PF01947.16 EDK41793.2 - 0.065 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 p-hydroxybenzoic acid synthase Zn_clus PF00172.18 EDK41795.2 - 1.4e-05 25.1 13.4 2.4e-05 24.4 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 EDK41795.2 - 0.012 15.6 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold ABC2_membrane PF01061.24 EDK41796.2 - 1.9e-25 89.5 33.3 2.6e-25 89.1 33.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EDK41796.2 - 4.8e-23 82.2 0.2 8.1e-23 81.5 0.2 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDK41796.2 - 6.2e-08 32.8 0.1 0.0063 16.4 0.0 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDK41796.2 - 0.00011 22.6 0.2 0.0002 21.8 0.2 1.4 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 EDK41796.2 - 0.00057 19.4 0.1 0.0014 18.1 0.1 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EDK41796.2 - 0.00072 19.8 1.5 0.01 16.1 1.5 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDK41796.2 - 0.0035 16.9 0.4 0.011 15.4 0.5 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDK41796.2 - 0.0041 17.7 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDK41796.2 - 0.011 16.0 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EDK41796.2 - 0.013 16.0 0.1 0.058 13.8 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 EDK41796.2 - 0.025 14.8 0.0 0.11 12.7 0.0 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EDK41796.2 - 0.03 14.8 0.5 0.053 14.0 0.1 1.6 2 0 0 2 2 1 0 AAA domain AAA_29 PF13555.6 EDK41796.2 - 0.034 13.9 1.8 0.07 12.9 1.8 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PDR_assoc PF08370.11 EDK41796.2 - 0.037 13.8 0.2 0.037 13.8 0.2 2.1 2 0 0 2 2 1 0 Plant PDR ABC transporter associated AAA_28 PF13521.6 EDK41796.2 - 0.039 14.2 0.1 0.067 13.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDK41796.2 - 0.046 13.7 0.1 0.16 12.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EDK41796.2 - 0.05 13.5 1.5 0.076 12.9 0.7 1.6 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EDK41796.2 - 0.059 13.0 0.2 0.1 12.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EDK41796.2 - 0.3 10.8 1.9 0.63 9.7 1.9 1.4 1 0 0 1 1 1 0 AAA domain PAP2_3 PF14378.6 EDK41797.2 - 8.2e-17 61.5 20.1 1.6e-16 60.5 20.1 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.21 EDK41797.2 - 1.5e-12 47.4 7.4 1.5e-12 47.4 7.4 2.2 2 0 0 2 2 2 1 PAP2 superfamily PsbY PF06298.11 EDK41797.2 - 0.27 11.2 2.7 0.53 10.2 0.3 2.3 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) LicD PF04991.13 EDK41798.2 - 8.5e-26 91.5 1.2 1e-20 74.9 0.5 3.4 2 2 1 3 3 3 2 LicD family Aldo_ket_red PF00248.21 EDK41799.2 - 1.5e-48 165.5 0.0 3.1e-46 157.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 EDK41800.2 - 9.2e-49 166.2 0.0 1.1e-35 123.2 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family MFS_1 PF07690.16 EDK41801.2 - 5.8e-27 94.5 14.9 5.8e-27 94.5 14.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TMEM234 PF10639.9 EDK41801.2 - 0.17 11.9 5.1 0.72 9.9 0.5 3.0 2 1 0 3 3 3 0 Putative transmembrane family 234 CPP1-like PF11833.8 EDK41801.2 - 0.35 10.5 2.1 5.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Transp_cyt_pur PF02133.15 EDK41802.2 - 2.6e-70 237.4 39.5 3.2e-70 237.1 39.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RAI1 PF08652.11 EDK41803.2 - 0.00094 19.3 0.0 0.0051 17.0 0.0 2.2 1 1 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease RAI1 PF08652.11 EDK41805.2 - 0.0034 17.5 1.3 0.011 16.0 0.0 2.5 2 1 1 3 3 3 1 RAI1 like PD-(D/E)XK nuclease Peptidase_S8 PF00082.22 EDK41807.2 - 3.2e-27 95.6 8.9 2.1e-26 92.9 8.9 1.9 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDK41807.2 - 2.1e-11 44.3 0.0 4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Hyphal_reg_CWP PF11765.8 EDK41808.2 - 2e-113 378.7 12.8 4.6e-113 377.5 12.8 1.7 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.6 EDK41808.2 - 4.5e-11 43.1 20.3 4.5e-11 43.1 20.3 14.4 9 2 3 12 12 12 1 Flocculin type 3 repeat HSBP1 PF06825.12 EDK41809.2 - 0.019 14.8 1.1 0.049 13.5 1.1 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 AAA_5 PF07728.14 EDK41809.2 - 0.022 14.7 0.9 0.038 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NPV_P10 PF05531.12 EDK41809.2 - 0.023 15.1 1.4 0.023 15.1 1.4 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Packaging_FI PF14000.6 EDK41809.2 - 0.05 14.1 6.1 0.3 11.5 5.5 2.5 2 1 0 2 2 2 0 DNA packaging protein FI DUF1512 PF07431.12 EDK41809.2 - 0.051 12.6 2.9 2.2 7.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1512) DUF1664 PF07889.12 EDK41809.2 - 0.31 11.1 4.2 0.26 11.4 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) XhlA PF10779.9 EDK41809.2 - 0.4 10.9 5.1 1.2 9.4 4.7 2.1 1 1 0 1 1 1 0 Haemolysin XhlA TssO PF17561.2 EDK41809.2 - 0.89 9.6 9.9 0.12 12.5 4.5 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssO YtxH PF12732.7 EDK41809.2 - 2.7 8.6 6.0 0.67 10.5 0.8 2.5 3 1 0 3 3 3 0 YtxH-like protein LRR_8 PF13855.6 EDK41812.2 - 9e-08 31.8 11.3 0.26 11.1 0.9 6.6 3 2 5 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EDK41812.2 - 1.2e-07 31.9 16.4 0.12 12.8 0.3 8.6 6 2 3 10 10 10 2 Leucine Rich repeats (2 copies) FNIP PF05725.12 EDK41812.2 - 0.00091 19.3 14.0 0.3 11.3 0.0 5.8 6 2 1 7 7 7 3 FNIP Repeat LRR_6 PF13516.6 EDK41812.2 - 0.0016 18.4 4.3 59 4.1 0.0 7.1 8 0 0 8 8 8 0 Leucine Rich repeat MFS_1 PF07690.16 EDK41813.2 - 7.2e-36 123.8 38.6 7.2e-36 123.8 38.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EDK41813.2 - 3.3e-09 35.7 2.7 3.3e-09 35.7 2.7 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDK41813.2 - 0.00023 19.6 8.2 0.0011 17.4 8.2 2.0 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family F-box-like PF12937.7 EDK41814.2 - 0.08 12.8 0.2 0.18 11.8 0.2 1.6 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 EDK41815.2 - 4.9e-12 45.9 39.6 0.0013 19.1 1.9 8.3 4 3 5 9 9 9 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDK41815.2 - 2.5e-09 36.7 38.5 0.053 13.3 0.5 7.3 2 2 5 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 EDK41815.2 - 0.0087 15.6 11.8 6.3 6.3 2.0 4.2 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EDK41815.2 - 1.2 9.9 32.3 31 5.7 0.1 10.3 10 2 1 11 11 11 0 Leucine Rich Repeat LRR_6 PF13516.6 EDK41815.2 - 3.4 7.9 28.5 32 4.9 0.0 10.1 12 0 0 12 12 12 0 Leucine Rich repeat Say1_Mug180 PF10340.9 EDK41816.2 - 1.2e-28 100.0 0.0 1.8e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EDK41816.2 - 1.8e-16 60.7 0.0 2.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDK41816.2 - 0.012 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EDK41816.2 - 0.055 12.4 0.0 0.087 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme LRR_6 PF13516.6 EDK41817.2 - 4.5e-06 26.3 6.1 12 6.2 0.0 9.1 10 0 0 10 10 10 1 Leucine Rich repeat LRR_8 PF13855.6 EDK41817.2 - 4.8e-06 26.3 20.4 0.011 15.5 0.1 7.2 4 2 3 7 7 7 3 Leucine rich repeat LRR_4 PF12799.7 EDK41817.2 - 0.00017 21.9 40.3 0.12 12.9 0.6 8.9 7 2 4 12 12 12 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EDK41817.2 - 0.027 14.0 3.4 1.2 8.6 0.1 3.1 3 0 0 3 3 3 0 Leucine-rich repeat COX1 PF00115.20 EDK41818.2 - 7.2e-06 25.1 2.6 8.5e-06 24.9 2.6 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I LAGLIDADG_1 PF00961.19 EDK41818.2 - 0.016 16.2 1.1 0.016 16.2 1.1 2.5 2 1 1 3 3 3 0 LAGLIDADG endonuclease Proton_antipo_M PF00361.20 EDK41819.1 - 8.2e-22 77.7 7.9 8.2e-22 77.7 7.9 2.5 1 1 1 3 3 3 1 Proton-conducting membrane transporter NADH5_C PF06455.11 EDK41819.1 - 8.6e-12 45.0 11.1 8.6e-12 45.0 11.1 2.6 2 1 0 2 2 2 1 NADH dehydrogenase subunit 5 C-terminus Med6 PF04934.14 EDK41819.1 - 0.029 14.1 0.3 0.07 12.9 0.3 1.6 1 0 0 1 1 1 0 MED6 mediator sub complex component Proton_antipo_M PF00361.20 EDK41820.1 - 1.6e-16 60.3 5.3 2.2e-16 59.9 5.3 1.2 1 0 0 1 1 1 1 Proton-conducting membrane transporter Cytochrom_B_C PF00032.17 EDK41821.1 - 1.9e-33 114.8 0.8 1.9e-33 114.8 0.8 1.8 2 0 0 2 2 2 1 Cytochrome b(C-terminal)/b6/petD GIY-YIG PF01541.24 EDK41822.1 - 5.8e-08 32.9 3.9 1.3e-07 31.8 3.9 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain NUMOD1 PF07453.13 EDK41822.1 - 8.3e-07 29.1 5.0 0.00044 20.4 0.9 2.7 2 0 0 2 2 2 2 NUMOD1 domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Meyerozyma_guilliermondii_ATCC_6260-ASM14942v1/GCA_000149425.1_ASM14942v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Meyerozyma_guilliermondii_ATCC_6260-ASM14942v1/GCA_000149425.1_ASM14942v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Meyerozyma_guilliermondii_ATCC_6260-ASM14942v1/GCA_000149425.1_ASM14942v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Meyerozyma_guilliermondii_ATCC_6260-ASM14942v1/GCA_000149425.1_ASM14942v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 00:56:27 2019 # [ok]