# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- SUR7 PF06687.7 EDK35903.2 - 3.8e-07 29.8 9.4 5.5e-07 29.3 6.5 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EDK35903.2 - 6.5e-06 26.1 5.9 6.5e-06 26.1 4.1 2.1 3 0 0 3 3 3 1 Ca2+ regulator and membrane fusion protein Fig1 DUF4293 PF14126.1 EDK35903.2 - 3.8 7.4 9.7 42 4.0 3.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4293) Vma12 PF11712.3 EDK35903.2 - 5.8 6.6 9.0 4.7 6.9 3.6 2.3 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Asp PF00026.18 EDK35904.2 - 1.2e-58 198.8 8.8 2.2e-58 198.0 6.1 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EDK35904.2 - 1.1e-08 35.3 0.7 0.0065 16.9 0.2 3.6 3 0 0 3 3 3 3 Aspartyl protease TAXi_N PF14543.1 EDK35904.2 - 0.00017 21.5 0.0 0.00059 19.8 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal RVP PF00077.15 EDK35904.2 - 0.0011 18.8 0.0 1.8 8.5 0.0 3.1 3 0 0 3 3 3 2 Retroviral aspartyl protease gag-asp_proteas PF13975.1 EDK35904.2 - 0.022 14.5 0.1 7.7 6.4 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_C PF14541.1 EDK35904.2 - 0.025 14.1 0.0 0.68 9.4 0.0 2.5 1 1 0 2 2 2 0 Xylanase inhibitor C-terminal MARVEL PF01284.18 EDK35905.2 - 5.3e-12 45.7 20.5 6.9e-12 45.3 14.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF3087 PF11286.3 EDK35905.2 - 0.18 11.0 1.2 0.33 10.1 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) DUF676 PF05057.9 EDK35906.2 - 0.074 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 EDK35906.2 - 0.083 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DCR PF14047.1 EDK35907.1 - 1.9 8.8 6.5 1.8 8.9 2.1 2.6 3 1 0 3 3 3 0 Dppa2/4 conserved region DUF2264 PF10022.4 EDK35908.2 - 1.8e-120 401.9 0.0 2.4e-120 401.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Glyco_hydro_2_C PF02836.12 EDK35911.2 - 6.9e-100 333.7 0.0 1.1e-99 333.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.12 EDK35911.2 - 6.5e-47 159.8 0.0 1e-46 159.1 0.0 1.3 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.13 EDK35911.2 - 7.4e-41 139.4 0.3 9.7e-40 135.8 0.3 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 EDK35911.2 - 4.1e-09 36.8 9.0 5.3e-09 36.5 0.0 3.0 3 0 0 3 3 3 1 Glycosyl hydrolases family 2 Sugar_tr PF00083.19 EDK35912.2 - 8.5e-70 235.5 24.0 1.1e-69 235.2 16.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK35912.2 - 1.1e-25 90.1 19.5 1.1e-25 90.1 13.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK35912.2 - 4.8e-07 28.3 0.8 4.8e-07 28.3 0.6 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ABC2_membrane PF01061.19 EDK35913.2 - 1.8e-45 154.6 23.1 1.8e-45 154.6 16.0 2.2 3 0 0 3 3 3 1 ABC-2 type transporter PDR_CDR PF06422.7 EDK35913.2 - 3.9e-36 122.8 0.1 3.9e-36 122.8 0.0 2.1 2 0 0 2 2 1 1 CDR ABC transporter ABC_tran PF00005.22 EDK35913.2 - 3.5e-32 111.5 0.0 1.1e-19 71.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 EDK35913.2 - 2e-24 85.4 0.0 5.4e-24 84.0 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 EDK35913.2 - 3.9e-09 36.2 0.0 0.00015 21.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EDK35913.2 - 2.3e-08 33.3 0.1 9.6e-06 24.8 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_19 PF13245.1 EDK35913.2 - 9.2e-06 25.3 0.0 0.063 13.0 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_23 PF13476.1 EDK35913.2 - 1.2e-05 25.7 0.6 0.19 12.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.1 EDK35913.2 - 1.6e-05 24.3 0.3 0.045 13.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain cobW PF02492.14 EDK35913.2 - 0.00046 19.6 2.0 0.08 12.3 0.2 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 EDK35913.2 - 0.00054 19.9 0.4 0.058 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.1 EDK35913.2 - 0.00058 19.8 0.5 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.2 EDK35913.2 - 0.0008 18.5 12.7 0.0008 18.5 8.8 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_10 PF12846.2 EDK35913.2 - 0.002 17.6 2.2 1.3 8.4 0.0 2.9 3 0 0 3 3 3 2 AAA-like domain NACHT PF05729.7 EDK35913.2 - 0.0021 17.7 1.9 2.1 7.9 0.1 3.3 3 0 0 3 3 3 1 NACHT domain AAA_17 PF13207.1 EDK35913.2 - 0.003 18.3 0.1 2 9.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EDK35913.2 - 0.0035 17.4 0.5 0.88 9.7 0.1 2.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EDK35913.2 - 0.0037 17.2 0.4 0.99 9.3 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 EDK35913.2 - 0.0051 16.6 0.2 1.8 8.4 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EDK35913.2 - 0.0067 16.7 2.1 1.3 9.3 0.0 3.2 3 0 0 3 3 2 1 AAA domain UPF0079 PF02367.12 EDK35913.2 - 0.0068 16.0 0.2 0.41 10.2 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ABC_ATPase PF09818.4 EDK35913.2 - 0.01 14.4 0.1 0.22 10.0 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_30 PF13604.1 EDK35913.2 - 0.011 15.3 0.5 1.6 8.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 EDK35913.2 - 0.038 13.6 0.0 8.4 6.0 0.0 2.7 2 0 0 2 2 2 0 Archaeal ATPase Miro PF08477.8 EDK35913.2 - 0.084 13.3 0.2 30 5.1 0.1 2.8 2 0 0 2 2 2 0 Miro-like protein FtsK_SpoIIIE PF01580.13 EDK35913.2 - 0.088 12.2 0.1 16 4.9 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family ABC2_membrane PF01061.19 EDK35914.1 - 2.9e-45 154.0 24.7 2.9e-45 154.0 17.1 2.0 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.7 EDK35914.1 - 0.00032 20.3 0.2 0.0011 18.5 0.2 1.9 1 0 0 1 1 1 1 CDR ABC transporter SMC_N PF02463.14 EDK35914.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.2 EDK35914.1 - 1.6 7.7 24.1 24 3.8 17.6 1.9 1 1 1 2 2 2 0 ABC-2 family transporter protein Fungal_trans_2 PF11951.3 EDK35915.2 - 1.6e-38 132.3 3.9 2.3e-38 131.7 2.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK35915.2 - 2.5e-09 36.8 9.5 6.6e-09 35.5 6.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.19 EDK35916.2 - 2.1e-49 168.3 0.0 2.5e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EDK35916.2 - 1.2e-05 25.3 0.0 0.0089 15.9 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK35916.2 - 3.3e-05 23.8 0.0 8.8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 EDK35916.2 - 0.00079 18.3 0.0 0.9 8.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A ThiF PF00899.16 EDK35916.2 - 0.0084 15.9 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 ThiF family FAD_binding_2 PF00890.19 EDK35916.2 - 0.019 13.7 0.0 0.23 10.2 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.1 EDK35916.2 - 0.053 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.12 EDK35916.2 - 0.075 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.14 EDK35916.2 - 0.08 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ATG22 PF11700.3 EDK35917.2 - 6e-102 341.5 23.1 6.7e-102 341.4 16.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 EDK35917.2 - 2.1e-05 23.4 7.0 2.1e-05 23.4 4.8 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.11 EDK35917.2 - 0.00019 20.3 7.2 0.00019 20.3 5.0 1.5 1 1 0 2 2 2 1 BT1 family DUF2207 PF09972.4 EDK35917.2 - 3 6.3 11.3 0.35 9.4 0.1 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Fungal_trans_2 PF11951.3 EDK35918.2 - 3.2e-05 22.7 0.7 4e-05 22.4 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.3 EDK35919.2 - 1.1e-14 53.8 0.5 1.4e-14 53.5 0.3 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain V_cholerae_RfbT PF05575.6 EDK35919.2 - 0.03 13.3 0.2 0.044 12.8 0.2 1.4 1 0 0 1 1 1 0 Vibrio cholerae RfbT protein DAO PF01266.19 EDK35920.2 - 7.3e-23 81.0 0.2 1.6e-21 76.6 0.1 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EDK35920.2 - 0.00011 22.1 0.7 0.0019 18.2 0.3 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EDK35920.2 - 0.00075 19.8 0.5 0.0016 18.7 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 EDK35920.2 - 0.00095 19.3 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding ApbA PF02558.11 EDK35920.2 - 0.0013 18.2 0.4 0.0024 17.3 0.3 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.9 EDK35920.2 - 0.002 18.0 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK35920.2 - 0.0055 16.1 0.9 0.015 14.6 0.4 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 EDK35920.2 - 0.012 15.2 0.2 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 EDK35920.2 - 0.017 14.2 0.3 0.029 13.4 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.16 EDK35920.2 - 0.023 14.5 0.2 0.038 13.8 0.1 1.3 1 0 0 1 1 1 0 ThiF family Thi4 PF01946.12 EDK35920.2 - 0.049 12.7 0.0 0.096 11.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.19 EDK35920.2 - 0.14 10.9 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Saccharop_dh PF03435.13 EDK35920.2 - 0.15 11.0 0.2 0.23 10.3 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 EDK35920.2 - 0.18 11.7 0.2 0.4 10.6 0.1 1.5 1 0 0 1 1 1 0 NADH(P)-binding ATG22 PF11700.3 EDK35921.2 - 3.8e-123 411.4 23.2 4.3e-123 411.2 16.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like BT1 PF03092.11 EDK35921.2 - 0.0073 15.0 7.8 0.015 14.0 5.4 1.4 1 0 0 1 1 1 1 BT1 family ApbA_C PF08546.6 EDK35922.2 - 5.4e-28 97.4 0.0 2.6e-27 95.2 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EDK35922.2 - 1.5e-27 95.9 0.1 2e-27 95.4 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA bZIP_1 PF00170.16 EDK35923.2 - 4.7e-05 23.2 12.9 6e-05 22.9 8.1 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 EDK35923.2 - 0.0084 15.9 14.6 0.017 14.9 10.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper HALZ PF02183.13 EDK35923.2 - 0.048 13.3 0.6 0.048 13.3 0.4 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DivIC PF04977.10 EDK35923.2 - 0.13 11.8 3.3 0.29 10.6 1.3 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF4140 PF13600.1 EDK35923.2 - 2.1 8.8 4.6 2.9 8.3 2.4 1.8 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) IncA PF04156.9 EDK35923.2 - 7.2 6.1 7.9 10 5.6 5.4 1.4 1 1 0 1 1 1 0 IncA protein adh_short PF00106.20 EDK35924.2 - 3.1e-14 53.2 0.0 5.6e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK35924.2 - 1.4e-06 28.1 0.0 3.2e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 EDK35924.2 - 2.1e-06 27.6 0.1 3.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EDK35924.2 - 2.8e-05 23.6 0.1 0.00012 21.6 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EDK35924.2 - 0.00055 19.2 0.6 0.00088 18.5 0.1 1.5 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.1 EDK35924.2 - 0.00056 19.9 0.0 0.0017 18.3 0.0 1.8 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK35924.2 - 0.0039 16.1 0.5 0.024 13.5 0.3 2.4 1 1 0 1 1 1 1 Male sterility protein bZIP_1 PF00170.16 EDK35925.2 - 1.1e-06 28.4 11.0 1.9e-06 27.7 7.4 1.5 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.10 EDK35925.2 - 0.013 15.0 3.2 0.02 14.3 1.4 1.9 1 1 1 2 2 2 0 Septum formation initiator DUF4200 PF13863.1 EDK35925.2 - 0.02 14.8 4.9 0.035 14.0 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) HALZ PF02183.13 EDK35925.2 - 0.031 13.9 0.2 0.082 12.6 0.2 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_2 PF07716.10 EDK35925.2 - 0.043 13.6 9.4 0.077 12.8 6.5 1.4 1 0 0 1 1 1 0 Basic region leucine zipper IncA PF04156.9 EDK35925.2 - 0.055 13.0 3.7 0.08 12.5 2.6 1.2 1 0 0 1 1 1 0 IncA protein CABS1 PF15367.1 EDK35925.2 - 0.073 11.9 0.2 0.093 11.5 0.1 1.1 1 0 0 1 1 1 0 Calcium-binding and spermatid-specific protein 1 FlaC_arch PF05377.6 EDK35925.2 - 2.4 8.1 5.3 9.5 6.2 2.4 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) adh_short PF00106.20 EDK35926.1 - 1.1e-14 54.6 0.0 2.2e-14 53.7 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK35926.1 - 1.6e-08 34.4 0.0 4.5e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.1 EDK35926.1 - 2.2e-07 31.0 0.1 1.5e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK35926.1 - 4.4e-07 29.5 0.1 1.3e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 EDK35926.1 - 5.1e-07 29.6 0.1 8.2e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.8 EDK35926.1 - 0.0003 20.1 0.6 0.00044 19.5 0.1 1.4 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.7 EDK35926.1 - 0.00034 19.6 0.6 0.002 17.0 0.4 2.4 1 1 0 1 1 1 1 Male sterility protein Cas_DxTHG PF09455.5 EDK35926.1 - 0.015 14.4 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family 3Beta_HSD PF01073.14 EDK35926.1 - 0.073 11.7 0.1 0.11 11.1 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family AA_permease_2 PF13520.1 EDK35927.2 - 2.2e-14 52.8 13.4 2.7e-14 52.5 9.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3444 PF11926.3 EDK35927.2 - 0.032 13.4 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3444) AA_permease_2 PF13520.1 EDK35928.2 - 6.5e-37 127.0 32.5 7.3e-37 126.9 22.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK35928.2 - 6.2e-05 21.5 25.2 9.6e-05 20.8 17.5 1.3 1 1 0 1 1 1 1 Amino acid permease DUF4190 PF13828.1 EDK35928.2 - 6.1 6.4 12.6 1.1 8.8 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4190) CAP PF00188.21 EDK35929.2 - 2.2e-16 60.4 3.3 2.2e-16 60.4 2.3 1.5 2 0 0 2 2 2 1 Cysteine-rich secretory protein family PA_decarbox PF05870.6 EDK35930.1 - 2.1e-22 79.3 0.4 2.6e-22 79.0 0.3 1.0 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) MoaF PF10703.4 EDK35930.1 - 0.0019 17.3 0.3 0.0025 16.9 0.2 1.1 1 0 0 1 1 1 1 Molybdenum cofactor biosynthesis protein F CRAL_TRIO PF00650.15 EDK35931.2 - 5.3e-30 104.0 0.1 1.1e-29 103.0 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 EDK35931.2 - 9.4e-05 22.3 0.0 0.0002 21.3 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EDK35931.2 - 0.00016 21.7 0.0 0.00064 19.7 0.0 2.1 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Redoxin PF08534.5 EDK35931.2 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Redoxin PHD PF00628.24 EDK35932.2 - 8.5e-07 28.5 7.1 1.5e-06 27.7 4.9 1.5 1 0 0 1 1 1 1 PHD-finger Corona_S2 PF01601.11 EDK35932.2 - 0.0032 15.6 1.5 0.004 15.3 1.0 1.1 1 0 0 1 1 1 1 Coronavirus S2 glycoprotein Ecl1 PF12855.2 EDK35932.2 - 0.02 14.1 0.2 0.13 11.6 0.0 2.2 2 0 0 2 2 2 0 Life-span regulatory factor RAG2_PHD PF13341.1 EDK35932.2 - 0.11 12.4 1.0 0.18 11.8 0.2 1.7 2 0 0 2 2 2 0 RAG2 PHD domain UTP15_C PF09384.5 EDK35933.2 - 1.3e-49 167.6 0.0 2.1e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 EDK35933.2 - 1.1e-17 63.1 8.1 2.8e-05 23.8 0.1 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 EDK35933.2 - 0.0001 22.0 0.0 0.091 12.5 0.0 3.2 1 1 2 3 3 3 2 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 EDK35934.2 - 3.3e-39 131.3 31.2 8.3e-08 31.8 0.0 11.7 12 0 0 12 12 12 7 WD domain, G-beta repeat Gmad1 PF10647.4 EDK35934.2 - 8.6e-06 25.3 0.3 0.00035 20.0 0.1 2.6 2 0 0 2 2 2 2 Lipoprotein LpqB beta-propeller domain Mitofilin PF09731.4 EDK35935.2 - 8.8e-124 414.2 19.1 1.2e-107 361.0 13.0 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein Exonuc_VII_L PF02601.10 EDK35935.2 - 0.015 14.5 16.6 0.1 11.8 10.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit HLH PF00010.21 EDK35935.2 - 0.041 13.5 0.4 3.7 7.3 0.0 3.4 3 0 0 3 3 3 0 Helix-loop-helix DNA-binding domain MAAL_C PF07476.6 EDK35935.2 - 0.046 12.6 0.1 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Phasin PF05597.6 EDK35935.2 - 0.13 11.9 10.3 1 9.1 2.1 3.3 2 2 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ApoLp-III PF07464.6 EDK35935.2 - 1.1 9.3 17.9 0.12 12.3 4.5 2.7 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) ADPrib_exo_Tox PF03496.9 EDK35935.2 - 1.4 8.1 7.5 0.26 10.4 2.7 1.7 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme DUF4407 PF14362.1 EDK35935.2 - 1.6 7.5 8.1 2.9 6.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Syntaxin_2 PF14523.1 EDK35935.2 - 2.2 8.3 20.0 3.4 7.7 0.4 4.4 3 1 1 4 4 4 0 Syntaxin-like protein NPV_P10 PF05531.7 EDK35935.2 - 3 8.1 11.1 1.6 8.9 2.2 3.7 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein UPF0184 PF03670.8 EDK35935.2 - 3.4 7.9 8.0 1.7 8.8 0.5 3.2 2 2 0 2 2 2 0 Uncharacterised protein family (UPF0184) BMFP PF04380.8 EDK35935.2 - 5.5 7.1 11.0 0.82 9.8 2.6 3.1 3 0 0 3 3 3 0 Membrane fusogenic activity Actin PF00022.14 EDK35936.2 - 6.2e-106 354.1 0.0 7.4e-106 353.8 0.0 1.1 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EDK35936.2 - 0.00026 19.6 0.0 0.36 9.3 0.1 2.3 2 1 0 2 2 2 2 MreB/Mbl protein Pap_E4 PF02711.9 EDK35936.2 - 0.63 10.8 2.9 2.7 8.8 0.3 2.4 2 0 0 2 2 2 0 E4 protein Alpha-amylase_C PF02806.13 EDK35937.1 - 5.8e-23 80.8 0.1 1.8e-22 79.2 0.1 1.9 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 EDK35937.1 - 1.7e-16 60.5 5.3 3.3e-15 56.3 0.0 3.0 2 1 1 3 3 3 2 Alpha amylase, catalytic domain CBM_48 PF02922.13 EDK35937.1 - 1.2e-12 47.6 0.1 3.5e-12 46.1 0.1 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Ku PF02735.11 EDK35939.2 - 2.3e-21 76.1 0.0 4e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain MMR_HSR1 PF01926.18 EDK35940.2 - 9e-14 51.4 0.2 1.4e-12 47.5 0.0 2.6 2 1 1 3 3 3 1 50S ribosome-binding GTPase DUF258 PF03193.11 EDK35940.2 - 5.3e-05 22.4 0.2 0.00011 21.4 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 EDK35940.2 - 0.00015 21.1 0.2 0.0015 17.7 0.2 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.11 EDK35940.2 - 0.013 14.6 0.2 0.039 13.0 0.0 2.0 2 0 0 2 2 2 0 AIG1 family IIGP PF05049.8 EDK35940.2 - 0.074 11.8 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ArgK PF03308.11 EDK35940.2 - 0.12 11.1 1.0 3.5 6.3 0.0 2.8 2 2 1 3 3 3 0 ArgK protein KTI12 PF08433.5 EDK35941.1 - 5.8e-97 324.1 0.2 6.5e-97 323.9 0.2 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 EDK35941.1 - 9.4e-05 22.3 0.0 0.00023 21.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK35941.1 - 0.00015 22.5 0.0 0.00038 21.2 0.0 1.6 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.17 EDK35941.1 - 0.0022 18.1 0.0 0.0046 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.18 EDK35941.1 - 0.0037 17.2 0.0 0.015 15.2 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.1 EDK35941.1 - 0.01 16.1 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EDK35941.1 - 0.025 14.1 0.0 0.084 12.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 EDK35941.1 - 0.026 14.6 0.0 0.07 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.12 EDK35941.1 - 0.038 13.3 0.2 0.35 10.2 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase APS_kinase PF01583.15 EDK35941.1 - 0.055 13.1 0.1 0.14 11.8 0.0 1.6 1 1 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.1 EDK35941.1 - 0.057 13.4 0.3 0.57 10.1 0.0 2.3 1 1 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.1 EDK35941.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Utp11 PF03998.8 EDK35942.2 - 1.3e-74 251.0 34.3 1.5e-74 250.9 23.8 1.0 1 0 0 1 1 1 1 Utp11 protein Oligomerisation PF02410.10 EDK35943.2 - 2.6e-18 65.8 0.0 3.2e-17 62.3 0.0 2.4 2 0 0 2 2 2 1 Oligomerisation domain Drc1-Sld2 PF11719.3 EDK35944.2 - 1.6e-75 254.8 28.4 2e-74 251.2 19.7 1.9 1 1 0 1 1 1 1 DNA replication and checkpoint protein zf-C2HC5 PF06221.8 EDK35945.2 - 2e-23 81.8 6.0 3.8e-23 81.0 4.2 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type FYVE PF01363.16 EDK35945.2 - 0.21 11.5 2.7 0.51 10.2 1.8 1.6 1 0 0 1 1 1 0 FYVE zinc finger zinc_ribbon_2 PF13240.1 EDK35945.2 - 2.3 7.8 6.9 7.1 6.2 4.8 1.8 1 1 1 2 2 2 0 zinc-ribbon domain zf-CCCH PF00642.19 EDK35946.2 - 3.8e-11 42.3 34.2 8.3e-05 22.1 1.2 5.9 6 0 0 6 6 6 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EDK35946.2 - 3.2 7.9 28.3 1.9 8.5 2.3 5.0 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type Pkinase PF00069.20 EDK35947.2 - 6.5e-49 166.4 0.0 2.6e-48 164.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK35947.2 - 1.2e-23 83.5 0.0 5.3e-23 81.3 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase NRDE PF05742.7 EDK35948.2 - 2.5e-16 59.7 0.1 4.6e-16 58.9 0.0 1.6 1 1 0 1 1 1 1 NRDE protein DUF2305 PF10230.4 EDK35949.2 - 6e-67 225.8 0.0 6.9e-67 225.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 EDK35949.2 - 1.7e-12 47.7 0.0 2.2e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK35949.2 - 0.00039 20.1 0.0 0.00054 19.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 EDK35949.2 - 0.00096 18.5 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DLH PF01738.13 EDK35949.2 - 0.0058 15.9 0.1 0.03 13.6 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 EDK35949.2 - 0.041 13.4 0.0 0.52 9.8 0.0 2.1 1 1 0 2 2 2 0 alpha/beta hydrolase fold Methyltransf_31 PF13847.1 EDK35950.2 - 4.5e-14 52.2 0.1 9.2e-14 51.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EDK35950.2 - 2.4e-12 46.6 0.0 3.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.11 EDK35950.2 - 3.8e-10 39.2 0.0 4.9e-10 38.9 0.0 1.0 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.2 EDK35950.2 - 1.2e-09 38.6 0.0 5.2e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK35950.2 - 1.3e-09 38.1 0.0 3.2e-09 36.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK35950.2 - 9.4e-09 35.6 0.0 2.6e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK35950.2 - 2.1e-07 30.4 0.0 3.4e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 EDK35950.2 - 2.5e-06 27.3 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK35950.2 - 3.2e-06 27.4 0.0 9.3e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EDK35950.2 - 5.5e-06 25.3 0.1 8.2e-06 24.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.15 EDK35950.2 - 0.0001 21.5 0.0 0.00015 20.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 EDK35950.2 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_12 PF08242.7 EDK35950.2 - 0.00014 22.2 0.0 0.00033 21.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 EDK35950.2 - 0.001 18.5 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase TehB PF03848.9 EDK35950.2 - 0.0071 15.5 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB UPF0020 PF01170.13 EDK35950.2 - 0.011 15.3 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.1 EDK35950.2 - 0.014 15.0 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EDK35950.2 - 0.054 13.0 0.1 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.10 EDK35950.2 - 0.083 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 SelR PF01641.13 EDK35951.2 - 6.5e-51 171.2 0.1 7.6e-51 170.9 0.1 1.0 1 0 0 1 1 1 1 SelR domain GFA PF04828.9 EDK35951.2 - 0.015 15.2 0.9 0.37 10.7 0.1 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF1508 PF07411.7 EDK35951.2 - 0.018 14.4 0.0 0.11 11.9 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1508) Yippee-Mis18 PF03226.9 EDK35951.2 - 0.089 12.8 0.2 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RRN7 PF11781.3 EDK35951.2 - 0.12 11.8 1.7 1 8.9 0.2 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 DUF2296 PF10058.4 EDK35951.2 - 0.2 11.4 1.1 4 7.2 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DZR PF12773.2 EDK35951.2 - 0.22 11.3 4.5 1 9.2 0.4 2.4 1 1 1 2 2 2 0 Double zinc ribbon Steroid_dh PF02544.11 EDK35952.2 - 3.2e-28 98.3 3.9 5.8e-28 97.5 2.7 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 EDK35952.2 - 0.00079 18.7 2.1 0.0013 18.0 1.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 EDK35952.2 - 0.0036 17.3 0.7 0.0085 16.1 0.5 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase MBF1 PF08523.5 EDK35953.1 - 1.2e-24 86.1 1.5 1.2e-24 86.1 1.0 1.9 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 EDK35953.1 - 2.3e-14 52.9 0.3 7.7e-14 51.2 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.1 EDK35953.1 - 2.2e-07 30.9 0.1 6.2e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.2 EDK35953.1 - 1.4e-06 28.2 0.1 2.3e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.1 EDK35953.1 - 0.038 13.7 0.2 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.1 EDK35953.1 - 0.059 13.0 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TRAP-gamma PF07074.7 EDK35953.1 - 0.061 12.8 0.8 0.081 12.4 0.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) BCDHK_Adom3 PF10436.4 EDK35954.2 - 6e-30 103.9 0.3 1e-29 103.1 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EDK35954.2 - 3.1e-13 49.4 0.0 7.5e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EDK35954.2 - 9.5e-05 22.0 0.0 0.00018 21.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 EDK35954.2 - 0.073 12.8 0.0 0.29 10.9 0.0 1.9 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Cupin_8 PF13621.1 EDK35955.2 - 1.7e-10 40.8 0.0 2.7e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain PHD PF00628.24 EDK35955.2 - 5.4e-09 35.6 10.7 1.1e-08 34.6 7.4 1.5 1 0 0 1 1 1 1 PHD-finger JmjC PF02373.17 EDK35955.2 - 1.8e-07 31.3 0.1 3.6e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase AraC_binding PF02311.14 EDK35955.2 - 0.0019 17.9 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.6 EDK35955.2 - 0.014 14.8 0.0 0.038 13.4 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Prok-RING_1 PF14446.1 EDK35955.2 - 0.039 13.7 7.2 0.098 12.4 5.0 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Cupin_4 PF08007.7 EDK35955.2 - 0.08 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein Strep_his_triad PF04270.8 EDK35955.2 - 0.11 12.1 0.2 0.35 10.6 0.2 1.9 1 0 0 1 1 1 0 Streptococcal histidine triad protein Cupin_1 PF00190.17 EDK35955.2 - 0.13 11.7 0.0 0.38 10.1 0.0 1.9 2 0 0 2 2 2 0 Cupin DUF1423 PF07227.6 EDK35955.2 - 0.71 8.4 7.5 1 7.9 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) zf-HC5HC2H PF13771.1 EDK35955.2 - 1.5 9.0 7.4 1.1 9.4 2.9 2.4 2 1 0 2 2 2 0 PHD-like zinc-binding domain DUF2422 PF10337.4 EDK35956.2 - 4.9e-148 493.7 0.4 4.9e-148 493.7 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2422) DUF2421 PF10334.4 EDK35956.2 - 1.4e-81 273.4 0.0 6.7e-81 271.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) FUSC_2 PF13515.1 EDK35956.2 - 3.2e-07 30.3 14.0 3.2e-07 30.3 9.7 3.0 3 0 0 3 3 3 1 Fusaric acid resistance protein-like TetR_N PF00440.18 EDK35956.2 - 0.12 12.0 0.4 13 5.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Phage_holin_1 PF04531.8 EDK35956.2 - 0.21 11.6 1.7 2.9 7.9 0.0 3.6 3 0 0 3 3 3 0 Bacteriophage holin Arginosuc_synth PF00764.14 EDK35957.1 - 8.8e-159 528.6 0.0 1e-158 528.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 EDK35957.1 - 4.5e-06 26.3 0.0 6.4e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 EDK35957.1 - 4.5e-05 22.8 0.0 7.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 EDK35957.1 - 0.00084 17.9 0.0 0.0014 17.3 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Vhr1 PF04001.8 EDK35958.2 - 1.4e-42 143.5 1.8 4.7e-42 141.8 1.3 1.9 1 0 0 1 1 1 1 Transcription factor Vhr1 Ribonuclease_3 PF00636.21 EDK35958.2 - 0.052 13.9 0.0 0.49 10.8 0.0 2.5 2 1 0 2 2 2 0 Ribonuclease III domain HEAT_2 PF13646.1 EDK35960.2 - 1.2e-12 47.9 0.0 0.16 12.2 0.0 7.5 4 3 2 7 7 7 3 HEAT repeats HEAT PF02985.17 EDK35960.2 - 5.3e-10 38.5 5.4 0.031 14.3 0.0 8.4 10 0 0 10 10 10 3 HEAT repeat HEAT_EZ PF13513.1 EDK35960.2 - 3.6e-09 36.8 0.2 0.0096 16.3 0.1 6.5 5 1 0 5 5 5 1 HEAT-like repeat SF3b1 PF08920.5 EDK35960.2 - 2.5e-06 27.5 3.3 9.4e-05 22.4 0.1 2.5 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 Vac14_Fab1_bd PF12755.2 EDK35960.2 - 8.4e-06 26.0 0.8 7.7 6.9 0.0 6.7 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 EDK35960.2 - 5.9e-05 21.9 5.6 0.00022 20.0 0.0 3.7 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.3 EDK35960.2 - 0.00091 18.6 2.9 0.76 9.0 0.2 4.7 5 1 0 6 6 6 1 CLASP N terminal NUC173 PF08161.7 EDK35960.2 - 0.0049 16.2 1.2 0.34 10.2 0.0 3.1 3 0 0 3 3 3 1 NUC173 domain CAF-1_p150 PF11600.3 EDK35960.2 - 1.1 8.6 11.8 1.9 7.8 8.2 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Elong_Iki1 PF10483.4 EDK35961.2 - 3.8e-88 295.5 2.8 4.4e-88 295.2 1.9 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 KTI12 PF08433.5 EDK35961.2 - 0.0064 15.7 0.5 0.009 15.2 0.3 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 DUF3419 PF11899.3 EDK35961.2 - 0.0068 15.1 0.0 0.01 14.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) YkyA PF10368.4 EDK35961.2 - 0.042 13.1 2.8 0.083 12.2 1.9 1.4 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Gpi16 PF04113.9 EDK35963.2 - 8e-234 776.8 0.0 9.5e-234 776.6 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Mad3_BUB1_I PF08311.7 EDK35964.2 - 3.8e-40 136.5 1.1 1e-39 135.2 0.7 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.20 EDK35964.2 - 4.1e-18 65.4 0.0 9.7e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.6 EDK35964.2 - 2.8e-09 36.7 0.5 5.4e-08 32.6 0.1 2.6 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.12 EDK35964.2 - 2.5e-07 30.0 0.0 4.6e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Homeobox_KN PF05920.6 EDK35964.2 - 0.033 13.8 0.1 8 6.2 0.0 2.8 2 0 0 2 2 2 0 Homeobox KN domain Pex14_N PF04695.8 EDK35965.2 - 3e-38 130.9 2.6 3e-38 130.9 1.8 3.6 2 2 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CCDC84 PF14968.1 EDK35965.2 - 0.00096 18.7 6.7 0.0017 17.9 4.6 1.3 1 0 0 1 1 1 1 Coiled coil protein 84 IncA PF04156.9 EDK35965.2 - 0.0037 16.8 0.1 0.0037 16.8 0.1 2.0 2 0 0 2 2 2 1 IncA protein Sipho_Gp157 PF05565.6 EDK35965.2 - 0.016 14.8 7.2 0.046 13.2 5.0 1.8 1 0 0 1 1 1 0 Siphovirus Gp157 Tox-WTIP PF15654.1 EDK35965.2 - 0.041 13.4 0.4 0.041 13.4 0.3 2.0 2 0 0 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif Kinesin-relat_1 PF12711.2 EDK35965.2 - 0.055 13.8 0.7 0.055 13.8 0.5 2.7 1 1 1 2 2 2 0 Kinesin motor SlyX PF04102.7 EDK35965.2 - 0.057 13.7 2.9 1.4 9.3 0.2 3.4 3 1 0 3 3 3 0 SlyX FlaC_arch PF05377.6 EDK35965.2 - 4.3 7.2 15.2 11 6.0 0.1 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) V-SNARE PF05008.10 EDK35965.2 - 4.7 7.4 12.5 4.9 7.3 3.3 3.5 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF1664 PF07889.7 EDK35965.2 - 5.9 6.7 11.2 3.4 7.4 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HAUS-augmin3 PF14932.1 EDK35965.2 - 8.6 5.4 16.6 0.98 8.5 4.8 2.5 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 Med5 PF08689.5 EDK35967.2 - 1.1e-91 308.1 33.2 1.2e-91 307.9 23.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 EF-hand_2 PF09068.6 EDK35967.2 - 0.011 15.7 0.0 0.088 12.8 0.0 2.6 2 1 0 2 2 2 0 EF hand DNA_pol_B PF00136.16 EDK35969.2 - 1.8e-145 485.3 4.5 2.5e-145 484.8 3.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EDK35969.2 - 3.9e-86 288.8 0.9 9.1e-86 287.6 0.6 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EDK35969.2 - 5.7e-23 80.7 6.5 1.8e-22 79.1 4.5 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.4 EDK35969.2 - 0.0015 18.0 0.0 0.0033 16.9 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EDK35969.2 - 0.0033 17.2 0.7 0.016 15.0 0.1 2.6 2 1 0 2 2 2 1 RNase_H superfamily C1_1 PF00130.17 EDK35969.2 - 1.3 8.8 8.2 4.1 7.1 0.8 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.2 EDK35969.2 - 6.5 6.6 9.1 0.49 10.2 0.9 2.3 2 0 0 2 2 2 0 Double zinc ribbon HATPase_c PF02518.21 EDK35970.2 - 1.7e-28 98.5 0.2 3.5e-28 97.5 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EDK35970.2 - 6.9e-26 90.4 0.3 4.9e-25 87.7 0.1 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 EDK35970.2 - 4.9e-20 71.2 0.7 1.6e-18 66.4 0.4 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EDK35971.1 - 2e-36 123.9 11.5 1.9e-10 40.7 0.0 5.6 5 1 1 6 6 6 4 HAMP domain IL32 PF15225.1 EDK35971.1 - 0.0048 16.8 0.2 9.9 6.1 0.0 3.7 4 0 0 4 4 3 1 Interleukin 32 CMD PF02627.15 EDK35971.1 - 0.047 13.5 1.2 1.9 8.3 0.0 3.3 4 0 0 4 4 4 0 Carboxymuconolactone decarboxylase family PilJ PF13675.1 EDK35971.1 - 0.063 13.5 3.0 1.1 9.5 0.0 3.9 4 2 1 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term LytTR PF04397.10 EDK35971.1 - 0.071 13.1 1.1 18 5.5 0.0 4.0 5 0 0 5 5 5 0 LytTr DNA-binding domain Terpene_synth_C PF03936.11 EDK35971.1 - 0.08 12.1 0.0 0.74 8.9 0.0 2.3 1 1 1 2 2 2 0 Terpene synthase family, metal binding domain Gln-synt_C PF00120.19 EDK35971.1 - 0.092 11.8 1.1 11 5.0 0.0 3.3 4 0 0 4 4 4 0 Glutamine synthetase, catalytic domain ELL PF10390.4 EDK35971.1 - 0.095 11.9 0.6 0.9 8.7 0.0 2.7 3 1 0 4 4 4 0 RNA polymerase II elongation factor ELL EMG1 PF03587.9 EDK35971.1 - 0.15 11.3 3.1 33 3.6 2.1 3.3 1 1 0 1 1 1 0 EMG1/NEP1 methyltransferase DUF2365 PF10157.4 EDK35971.1 - 0.24 11.2 18.6 2.5 7.9 0.2 5.8 5 3 0 6 6 6 0 Uncharacterized conserved protein (DUF2365) Ste50p-SAM PF09235.5 EDK35971.1 - 0.25 11.4 4.3 24 5.0 0.0 4.1 4 1 0 4 4 4 0 Ste50p, sterile alpha motif DUF1693 PF07984.7 EDK35971.1 - 0.25 10.4 5.3 4 6.5 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1693) CENP-F_leu_zip PF10473.4 EDK35971.1 - 0.42 10.4 9.8 2.8 7.7 0.1 4.9 4 1 0 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1732 PF08340.6 EDK35971.1 - 4.5 7.1 8.7 12 5.7 0.0 5.0 6 1 0 6 6 6 0 Domain of unknown function (DUF1732) DUF2771 PF10969.3 EDK35972.2 - 0.086 12.1 0.1 0.66 9.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2771) adh_short_C2 PF13561.1 EDK35973.1 - 1.8e-25 90.0 0.0 2.4e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK35973.1 - 4.8e-24 85.1 1.7 6.7e-24 84.6 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK35973.1 - 5.2e-10 39.2 0.4 7.2e-10 38.8 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK35973.1 - 0.0072 15.7 0.3 0.015 14.7 0.1 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PDZ PF00595.19 EDK35973.1 - 0.021 14.9 0.5 0.043 13.9 0.4 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) CoA_binding_2 PF13380.1 EDK35973.1 - 0.034 14.2 0.6 0.12 12.5 0.1 1.9 2 0 0 2 2 2 0 CoA binding domain 3Beta_HSD PF01073.14 EDK35973.1 - 0.08 11.6 1.5 0.11 11.2 0.6 1.5 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_C14 PF00656.17 EDK35974.2 - 3.7e-76 256.1 0.1 4.8e-76 255.7 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.1 EDK35974.2 - 0.093 12.5 0.1 0.32 10.8 0.0 2.1 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain DUF1977 PF09320.6 EDK35975.2 - 1.6e-27 95.8 2.8 3e-27 94.9 2.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.26 EDK35975.2 - 6e-25 86.7 1.2 6e-25 86.7 0.8 1.7 2 0 0 2 2 2 1 DnaJ domain Mito_carr PF00153.22 EDK35976.2 - 5.3e-49 163.8 0.6 2.8e-15 55.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.16 EDK35977.2 - 6.2e-27 92.8 8.8 3.8e-07 29.5 0.3 5.7 6 1 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EDK35977.2 - 4.3e-13 49.6 0.1 0.0098 16.2 0.0 4.3 2 2 3 5 5 5 5 Prenyltransferase-like Herpes_LMP1 PF05297.6 EDK35978.1 - 0.16 10.8 13.2 0.18 10.6 9.1 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Daxx PF03344.10 EDK35979.2 - 0.97 7.8 21.4 1.4 7.3 14.8 1.2 1 0 0 1 1 1 0 Daxx Family TP53IP5 PF15331.1 EDK35979.2 - 6.7 6.5 6.2 8.3 6.2 4.3 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 ACPS PF01648.15 EDK35981.2 - 8.2e-09 35.2 0.0 3.3e-08 33.3 0.0 2.0 2 1 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily RNA_pol_Rpb1_3 PF04983.13 EDK35981.2 - 0.0017 18.1 0.1 0.097 12.3 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase Rpb1, domain 3 Beta_elim_lyase PF01212.16 EDK35982.2 - 4.7e-76 255.7 0.0 5.6e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EDK35982.2 - 0.00015 20.8 0.0 0.00029 19.8 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II DUF692 PF05114.8 EDK35982.2 - 0.1 11.4 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF692) Aldedh PF00171.17 EDK35983.1 - 1.4e-181 603.8 0.2 1.6e-181 603.6 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EDK35983.1 - 6.7e-06 25.0 0.1 1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) RNase_H PF00075.19 EDK35984.2 - 7.6e-25 87.7 0.2 1.5e-24 86.8 0.2 1.5 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 EDK35984.2 - 1.2e-16 60.4 3.0 2.2e-16 59.5 2.1 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin Cob_adeno_trans PF01923.13 EDK35984.2 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF1895 PF08988.5 EDK35984.2 - 0.11 12.5 0.1 0.52 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1895) RNase_H PF00075.19 EDK35985.2 - 8e-22 77.9 0.2 1.4e-21 77.2 0.2 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 EDK35985.2 - 3.9e-13 49.1 0.4 8.2e-13 48.1 0.3 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.19 EDK35986.2 - 3.8e-19 69.3 0.1 5.5e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 EDK35986.2 - 6.1e-12 45.3 0.6 1.2e-11 44.3 0.4 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin MFS_1 PF07690.11 EDK35987.2 - 5.7e-32 110.8 50.1 8e-32 110.3 34.0 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 EDK35987.2 - 0.0021 16.5 40.1 0.0093 14.4 13.2 3.3 2 1 1 3 3 3 3 MFS/sugar transport protein Abhydrolase_6 PF12697.2 EDK35988.2 - 8.6e-34 117.3 0.0 1.1e-33 117.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK35988.2 - 2.4e-26 92.7 0.0 9.9e-26 90.7 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK35988.2 - 5.7e-14 52.0 0.0 9.5e-13 48.1 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EDK35988.2 - 2.1e-05 24.2 0.0 8.2e-05 22.3 0.0 2.0 3 0 0 3 3 3 1 Putative lysophospholipase FSH1 PF03959.8 EDK35988.2 - 0.00026 20.5 0.0 0.065 12.6 0.0 2.4 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Ndr PF03096.9 EDK35988.2 - 0.0035 15.8 0.0 0.0048 15.4 0.0 1.2 1 0 0 1 1 1 1 Ndr family Phage_portal_2 PF05136.8 EDK35988.2 - 0.008 14.7 0.0 0.011 14.2 0.0 1.1 1 0 0 1 1 1 1 Phage portal protein, lambda family PapC_C PF13953.1 EDK35988.2 - 0.018 14.6 0.0 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 PapC C-terminal domain EHN PF06441.7 EDK35988.2 - 0.091 12.6 0.3 1.3 9.0 0.0 2.5 2 1 0 2 2 2 0 Epoxide hydrolase N terminus zf-C2H2 PF00096.21 EDK35989.2 - 6.6e-17 60.7 23.9 9e-05 22.5 0.2 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK35989.2 - 2.3e-14 52.8 28.6 1.3e-06 28.3 0.6 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK35989.2 - 3.4e-12 45.7 24.3 0.0028 17.8 0.5 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK35989.2 - 2.5e-07 30.6 13.1 0.00015 21.7 0.2 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK35989.2 - 0.0096 16.0 1.2 0.0096 16.0 0.9 5.0 4 1 1 5 5 5 1 Zinc-finger of C2H2 type RRN7 PF11781.3 EDK35989.2 - 0.18 11.3 4.8 4.5 6.8 0.1 3.8 4 0 0 4 4 4 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2_6 PF13912.1 EDK35989.2 - 0.26 11.2 8.8 0.5 10.3 0.2 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-RING_3 PF14369.1 EDK35989.2 - 0.62 10.1 4.3 6.2 6.9 0.0 3.5 3 0 0 3 3 3 0 zinc-finger IBR PF01485.16 EDK35989.2 - 1.5 8.7 12.1 96 2.9 7.2 3.6 2 1 1 3 3 3 0 IBR domain MobB PF03205.9 EDK35990.2 - 6.5e-10 38.8 0.0 1.8e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EDK35990.2 - 0.0012 18.7 0.0 0.003 17.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 EDK35990.2 - 0.011 15.2 0.1 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Nit_Regul_Hom PF10126.4 EDK35990.2 - 0.013 15.2 0.0 3.6 7.3 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII AAA_14 PF13173.1 EDK35990.2 - 0.026 14.4 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Clp1 PF06807.9 EDK35990.2 - 0.034 13.9 0.0 0.18 11.5 0.0 2.1 1 1 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 AAA_16 PF13191.1 EDK35990.2 - 0.06 13.3 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 EDK35990.2 - 0.062 12.7 0.0 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family SMC_N PF02463.14 EDK35990.2 - 0.074 12.2 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 EDK35990.2 - 0.075 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain DUF258 PF03193.11 EDK35990.2 - 0.15 11.2 0.1 0.34 10.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Lectin_leg-like PF03388.8 EDK35991.2 - 2.7e-17 62.6 0.7 4.1e-17 62.0 0.5 1.2 1 0 0 1 1 1 1 Legume-like lectin family CAP_N PF01213.14 EDK35991.2 - 0.0021 17.3 1.2 0.0033 16.7 0.8 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal PhoU PF01895.14 EDK35991.2 - 0.077 13.4 0.2 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 PhoU domain DUF848 PF05852.6 EDK35991.2 - 0.15 11.8 5.8 0.044 13.6 0.9 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF2458 PF10454.4 EDK35991.2 - 0.21 11.4 10.2 0.025 14.4 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) Syntaxin PF00804.20 EDK35991.2 - 0.37 10.9 11.9 0.8 9.9 0.3 2.6 1 1 1 2 2 2 0 Syntaxin Vir_act_alpha_C PF10400.4 EDK35991.2 - 1.2 9.5 4.0 6 7.2 0.6 3.0 2 1 0 2 2 2 0 Virulence activator alpha C-term DUF745 PF05335.8 EDK35991.2 - 9.4 5.7 9.1 16 4.9 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DEP PF00610.16 EDK35992.2 - 3.4e-16 58.7 0.0 7.5e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.22 EDK35992.2 - 4.5e-15 55.5 0.1 1.6e-14 53.7 0.1 2.0 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.18 EDK35992.2 - 7.3e-14 51.7 0.3 7.3e-14 51.7 0.2 3.9 4 0 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain Arf PF00025.16 EDK35994.1 - 1.4e-79 265.4 0.1 1.6e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EDK35994.1 - 2.3e-14 53.0 0.0 2.8e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EDK35994.1 - 2.4e-13 49.7 0.0 2.6e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EDK35994.1 - 2.3e-11 43.0 1.0 1.1e-08 34.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EDK35994.1 - 3.6e-11 42.6 0.0 4.3e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EDK35994.1 - 1.8e-08 34.8 0.0 2.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EDK35994.1 - 5.1e-05 23.2 0.0 6.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 EDK35994.1 - 0.0044 16.1 0.2 0.0067 15.5 0.1 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 EDK35994.1 - 0.017 14.5 0.1 0.11 11.8 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 EDK35994.1 - 0.077 12.8 0.1 0.15 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK35994.1 - 0.13 11.7 0.1 1.8 8.0 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ECH PF00378.15 EDK35995.1 - 1.6e-17 63.4 0.0 2.1e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family NPR3 PF03666.8 EDK35996.2 - 6.6e-158 525.9 5.9 4.4e-137 457.3 2.5 3.9 3 1 1 4 4 4 2 Nitrogen Permease regulator of amino acid transport activity 3 PRP8_domainIV PF12134.3 EDK35997.2 - 3.4e-124 412.6 0.6 6.1e-124 411.8 0.4 1.4 1 0 0 1 1 1 1 PRP8 domain IV core PROCN PF08083.6 EDK35997.2 - 2.1e-109 365.7 3.1 3.7e-109 364.9 2.2 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain U6-snRNA_bdg PF10596.4 EDK35997.2 - 1.1e-88 294.5 0.8 2.5e-88 293.4 0.5 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.4 EDK35997.2 - 2.3e-68 227.9 0.1 5.3e-68 226.8 0.1 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 EDK35997.2 - 2.5e-45 153.2 0.1 6.7e-45 151.8 0.0 1.9 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.4 EDK35997.2 - 1.4e-43 146.6 0.1 3.7e-43 145.3 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.16 EDK35997.2 - 0.03 14.0 0.0 0.083 12.6 0.0 1.8 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRO8NT PF08082.6 EDK35998.1 - 1.5e-74 248.6 2.5 3.1e-74 247.6 1.8 1.5 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain PROCN PF08083.6 EDK35998.1 - 1.1e-70 238.1 2.2 1.7e-70 237.5 1.5 1.2 1 0 0 1 1 1 1 PROCN (NUC071) domain zf-C3HC4_3 PF13920.1 EDK35999.2 - 2.2e-05 24.0 12.3 3.7e-05 23.3 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BatA PF07584.6 EDK35999.2 - 0.0022 18.1 0.2 0.0022 18.1 0.2 1.9 2 0 0 2 2 2 1 Aerotolerance regulator N-terminal Aminotran_1_2 PF00155.16 EDK36000.2 - 6.4e-39 133.9 0.0 7.3e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II APC8 PF04049.8 EDK36001.2 - 2.9e-37 127.5 1.8 3.4e-37 127.3 0.2 2.0 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 EDK36001.2 - 3.9e-26 89.5 18.8 8.6e-07 28.3 0.2 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.1 EDK36001.2 - 3.2e-21 74.7 14.1 3.8e-09 36.0 0.1 6.8 4 3 3 7 7 7 5 TPR repeat TPR_2 PF07719.12 EDK36001.2 - 1.9e-19 67.9 22.3 8.9e-06 25.2 0.1 8.6 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 EDK36001.2 - 4.8e-14 51.0 16.5 2.5e-05 23.7 0.4 7.1 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36001.2 - 6.3e-13 48.1 1.8 0.0008 19.8 0.0 7.9 5 3 3 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK36001.2 - 4.4e-12 46.3 11.4 3.1e-05 24.5 0.0 7.0 7 1 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 EDK36001.2 - 2.5e-10 40.1 22.7 0.00061 19.6 1.6 7.2 4 1 4 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.1 EDK36001.2 - 1.8e-09 37.0 7.3 0.019 15.1 0.1 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 EDK36001.2 - 1.5e-08 33.8 1.9 1.3 8.9 0.0 6.1 7 0 0 7 7 4 2 Tetratricopeptide repeat Apc3 PF12895.2 EDK36001.2 - 2.4e-07 30.8 22.6 0.018 15.1 0.9 5.5 2 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EDK36001.2 - 1.3e-06 28.6 8.0 0.71 10.2 0.6 6.1 5 2 2 7 7 7 3 Tetratricopeptide repeat ChAPs PF09295.5 EDK36001.2 - 3.5e-06 26.0 0.3 0.0082 14.9 0.0 3.7 3 1 1 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.1 EDK36001.2 - 0.00011 22.0 3.4 0.12 12.2 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat FNIP_C PF14638.1 EDK36001.2 - 0.084 12.2 0.1 1 8.6 0.0 2.3 2 0 0 2 2 2 0 Folliculin-interacting protein C-terminus PTH2 PF01981.11 EDK36001.2 - 0.11 12.1 0.1 1.2 8.8 0.0 2.5 2 1 1 3 3 3 0 Peptidyl-tRNA hydrolase PTH2 DUF3856 PF12968.2 EDK36001.2 - 0.69 9.7 5.3 9.1 6.0 0.4 3.4 3 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) MIT PF04212.13 EDK36001.2 - 5.1 7.0 10.5 16 5.4 0.1 4.5 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 EDK36001.2 - 7.4 7.2 19.1 12 6.6 0.0 6.9 8 1 1 9 9 5 0 Tetratricopeptide repeat MPC PF03650.8 EDK36002.1 - 5.4e-43 145.7 0.1 6e-43 145.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) ABC_membrane PF00664.18 EDK36003.2 - 2.2e-62 211.0 34.8 2.2e-32 112.5 9.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK36003.2 - 4.9e-49 166.1 0.0 1.8e-29 102.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EDK36003.2 - 6.1e-12 45.2 10.3 4.2e-05 22.8 1.1 4.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK36003.2 - 1.6e-07 31.5 6.0 0.37 10.7 0.8 5.4 3 2 1 4 4 4 2 AAA domain AAA_16 PF13191.1 EDK36003.2 - 1.4e-06 28.4 0.1 0.018 15.0 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EDK36003.2 - 8.7e-06 25.1 0.1 0.15 11.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EDK36003.2 - 6.4e-05 23.3 0.7 0.041 14.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EDK36003.2 - 8e-05 23.1 0.4 0.25 11.8 0.0 3.1 3 0 0 3 3 2 2 Miro-like protein MMR_HSR1 PF01926.18 EDK36003.2 - 0.00018 21.4 1.5 0.7 9.8 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_17 PF13207.1 EDK36003.2 - 0.00022 22.0 0.0 1.1 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EDK36003.2 - 0.00023 20.6 0.0 0.4 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 EDK36003.2 - 0.00039 19.4 0.0 0.71 8.7 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.18 EDK36003.2 - 0.00051 19.9 3.4 0.021 14.6 0.2 2.6 2 0 0 2 2 2 1 Dynamin family DUF258 PF03193.11 EDK36003.2 - 0.0017 17.5 0.1 2.1 7.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.12 EDK36003.2 - 0.0048 16.7 0.1 0.78 9.5 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_22 PF13401.1 EDK36003.2 - 0.007 16.5 1.4 7.9 6.6 0.0 4.0 3 1 0 3 3 3 0 AAA domain Zeta_toxin PF06414.7 EDK36003.2 - 0.0084 15.2 0.1 2.7 7.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin UPF0079 PF02367.12 EDK36003.2 - 0.036 13.6 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 SbcCD_C PF13558.1 EDK36003.2 - 0.04 13.8 0.1 2.4 8.1 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.13 EDK36003.2 - 0.052 13.0 0.0 5.3 6.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.2 EDK36003.2 - 0.062 12.7 2.2 6.3 6.1 0.2 3.1 3 0 0 3 3 3 0 AAA-like domain PRK PF00485.13 EDK36003.2 - 0.071 12.6 0.2 14 5.2 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.9 EDK36003.2 - 0.099 12.3 1.5 8.6 6.0 0.1 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AIG1 PF04548.11 EDK36003.2 - 1.1 8.3 3.9 7.8 5.5 0.5 2.5 2 0 0 2 2 2 0 AIG1 family Aconitase PF00330.15 EDK36004.1 - 4.7e-182 605.6 0.1 8.5e-182 604.7 0.0 1.4 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EDK36004.1 - 4.5e-45 152.9 0.0 9e-45 151.9 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Zn_clus PF00172.13 EDK36006.2 - 5.4e-09 35.8 6.8 1.2e-08 34.6 4.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK36006.2 - 2.6e-05 23.2 0.2 2.6e-05 23.2 0.1 2.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain Sec23_trunk PF04811.10 EDK36007.2 - 2.5e-72 243.1 0.0 3.7e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 EDK36007.2 - 3.3e-34 117.2 0.1 6.5e-34 116.3 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.10 EDK36007.2 - 7.7e-32 108.7 0.2 1.7e-31 107.6 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 EDK36007.2 - 1.2e-12 47.3 0.0 2.6e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.10 EDK36007.2 - 7.4e-12 44.6 8.8 1.5e-11 43.6 6.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger ThiF PF00899.16 EDK36008.2 - 1.6e-12 47.4 0.1 2.5e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 ThiF family HDA2-3 PF11496.3 EDK36009.2 - 8.3e-92 307.1 0.0 8.3e-92 307.1 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 GAS PF13851.1 EDK36009.2 - 0.0043 16.2 14.3 0.0043 16.2 9.9 2.4 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.6 EDK36009.2 - 0.017 14.5 28.9 0.042 13.2 6.7 2.6 1 1 0 2 2 2 0 Phage minor structural protein GP20 Cep57_CLD_2 PF14197.1 EDK36009.2 - 0.14 12.1 23.4 0.87 9.5 4.4 3.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.4 EDK36009.2 - 0.21 11.4 36.5 1.2 8.9 15.3 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.6 EDK36009.2 - 0.33 10.8 13.3 0.1 12.4 1.0 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) IncA PF04156.9 EDK36009.2 - 1.2 8.6 33.7 1.7 8.2 13.7 2.2 1 1 1 2 2 2 0 IncA protein DUF972 PF06156.8 EDK36009.2 - 2.3 8.5 24.0 15 6.0 4.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) WD40 PF00400.27 EDK36010.2 - 3.5e-54 178.8 23.1 1.8e-12 46.6 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.6 EDK36010.2 - 3e-11 42.3 1.7 5e-11 41.6 1.2 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Peptidase_M16 PF00675.15 EDK36011.2 - 4.5e-25 88.1 0.0 1.3e-24 86.6 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EDK36011.2 - 6.4e-09 35.7 0.6 0.0046 16.6 0.0 4.1 4 1 0 4 4 4 3 Peptidase M16 inactive domain DUF633 PF04816.7 EDK36011.2 - 0.11 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF633) DUF4452 PF14618.1 EDK36012.2 - 4.1e-26 91.7 13.2 3.7e-25 88.6 9.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4452) Cu_amine_oxid PF01179.15 EDK36013.2 - 1.6e-163 544.2 0.7 2e-163 543.9 0.5 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 EDK36013.2 - 1.7e-06 28.0 0.1 6e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain SRP1_TIP1 PF00660.12 EDK36014.2 - 1e-27 96.0 1.4 1.3e-27 95.6 1.0 1.1 1 0 0 1 1 1 1 Seripauperin and TIP1 family Pheromone PF08015.6 EDK36014.2 - 3.3 8.6 6.8 1.5 9.6 3.1 1.7 2 0 0 2 2 2 0 Fungal mating-type pheromone LRR_4 PF12799.2 EDK36016.2 - 1.1e-21 75.9 46.4 3.5e-09 36.0 6.6 5.2 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK36016.2 - 9.2e-15 54.1 21.1 1.6e-10 40.5 2.0 3.6 3 1 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 EDK36016.2 - 1.8e-05 24.1 23.0 0.091 12.8 1.1 6.6 4 1 1 5 5 5 3 Leucine Rich Repeat LRR_5 PF13306.1 EDK36016.2 - 0.00089 18.9 0.2 0.0027 17.3 0.1 1.9 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_7 PF13504.1 EDK36016.2 - 0.015 15.3 16.4 0.96 9.9 0.4 5.5 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 EDK36016.2 - 0.025 14.6 21.4 0.026 14.5 1.3 5.0 5 1 1 6 6 6 0 Leucine Rich repeat LRR_9 PF14580.1 EDK36016.2 - 0.031 13.8 7.7 0.036 13.6 2.4 2.6 2 1 1 3 3 3 0 Leucine-rich repeat Glyco_hydro_3 PF00933.16 EDK36017.1 - 8.4e-59 198.9 0.0 9.9e-59 198.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EDK36019.2 - 3.3e-53 180.5 0.0 8.3e-53 179.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EDK36019.2 - 9.2e-23 79.9 0.0 1.8e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.16 EDK36019.2 - 4.2e-13 48.9 0.0 9.8e-13 47.7 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain MFS_1 PF07690.11 EDK36020.2 - 3.3e-49 167.5 37.8 8.7e-48 162.8 26.8 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK36020.2 - 3.9e-17 61.6 22.3 7.2e-17 60.8 15.5 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EDK36020.2 - 3.6e-12 45.5 9.5 3.6e-12 45.5 6.6 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter Baculo_PEP_C PF04513.7 EDK36021.2 - 2.1 8.1 9.9 1.4 8.7 0.6 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YlqD PF11068.3 EDK36021.2 - 2.6 8.0 26.0 0.9 9.5 1.8 3.4 2 1 0 3 3 3 0 YlqD protein MerR-DNA-bind PF09278.6 EDK36021.2 - 4.2 7.8 15.0 7.8 6.9 1.2 3.8 3 0 0 3 3 3 0 MerR, DNA binding Fzo_mitofusin PF04799.8 EDK36021.2 - 9 5.6 20.8 7.7 5.8 1.6 3.4 2 1 1 3 3 3 0 fzo-like conserved region DNA_pol_E_B PF04042.11 EDK36022.2 - 5.4e-38 130.3 0.3 1.1e-37 129.4 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Prenyltrans PF00432.16 EDK36023.2 - 4.2e-60 198.9 0.6 2.6e-13 49.2 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EDK36023.2 - 1.3e-32 112.5 0.0 1.7e-16 60.6 0.0 4.0 2 2 2 4 4 4 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 EDK36023.2 - 2.9e-10 40.1 0.0 8.7e-06 25.7 0.0 3.9 2 1 2 4 4 4 4 Prenyltransferase-like Myb_DNA-bind_6 PF13921.1 EDK36024.2 - 2.5e-12 46.7 0.2 4.2e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EDK36024.2 - 2e-09 37.3 0.5 3.1e-09 36.7 0.4 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA PF00004.24 EDK36025.2 - 2.1e-39 134.7 0.0 5e-39 133.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EDK36025.2 - 2.1e-06 27.4 0.2 0.00023 20.9 0.0 3.4 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.1 EDK36025.2 - 3e-05 24.1 1.3 0.00078 19.5 0.2 2.9 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EDK36025.2 - 6.5e-05 22.0 0.0 0.00011 21.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EDK36025.2 - 0.00014 21.8 0.0 0.00032 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.8 EDK36025.2 - 0.00047 18.9 0.0 0.00075 18.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 EDK36025.2 - 0.00061 19.5 0.0 0.0027 17.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EDK36025.2 - 0.001 18.4 0.3 0.054 12.8 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 EDK36025.2 - 0.0024 17.7 0.0 0.0066 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EDK36025.2 - 0.0028 17.1 0.0 0.0051 16.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 EDK36025.2 - 0.0028 17.6 0.7 0.011 15.7 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.16 EDK36025.2 - 0.0035 16.5 0.1 0.0069 15.5 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 EDK36025.2 - 0.0074 17.0 0.4 0.04 14.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EDK36025.2 - 0.0092 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK36025.2 - 0.011 15.4 0.0 0.029 14.1 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain DUF815 PF05673.8 EDK36025.2 - 0.011 14.6 0.0 0.051 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.1 EDK36025.2 - 0.031 13.8 0.0 0.075 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EDK36025.2 - 0.045 13.4 0.3 0.21 11.2 0.0 2.3 3 0 0 3 3 3 0 NACHT domain Peptidase_M3_N PF08439.5 EDK36025.2 - 0.049 13.6 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 Oligopeptidase F Guanylate_kin PF00625.16 EDK36025.2 - 0.067 12.6 0.1 0.27 10.6 0.0 2.0 1 1 1 2 2 2 0 Guanylate kinase KaiC PF06745.8 EDK36025.2 - 0.069 12.2 0.0 1.1 8.3 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_18 PF13238.1 EDK36025.2 - 0.073 13.3 0.0 0.29 11.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EDK36025.2 - 0.086 12.0 0.0 0.24 10.5 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Arch_ATPase PF01637.13 EDK36025.2 - 0.093 12.4 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 Archaeal ATPase AAA_28 PF13521.1 EDK36025.2 - 0.094 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EDK36025.2 - 0.098 12.8 0.1 0.53 10.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.21 EDK36025.2 - 0.16 11.4 0.0 0.39 10.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MFS_1 PF07690.11 EDK36026.2 - 2.5e-43 148.1 53.0 4e-33 114.5 21.2 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36026.2 - 3e-12 45.8 4.5 3e-12 45.8 3.1 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 EDK36026.2 - 3e-12 45.5 15.6 4.7e-12 44.9 10.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 EDK36026.2 - 9.4e-08 30.8 30.8 0.00078 17.9 13.8 2.8 1 1 1 2 2 2 2 MFS/sugar transport protein DUF3526 PF12040.3 EDK36026.2 - 0.21 11.7 0.0 0.54 10.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3526) DnaJ-X PF14308.1 EDK36027.2 - 2.2e-69 232.8 10.3 4.7e-69 231.7 7.1 1.6 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.26 EDK36027.2 - 1.3e-23 82.4 0.5 1.3e-23 82.4 0.3 2.6 4 0 0 4 4 4 1 DnaJ domain UDPGT PF00201.13 EDK36027.2 - 0.096 11.2 2.6 0.13 10.7 1.8 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase PsaN PF05479.6 EDK36027.2 - 1.4 8.9 5.7 0.48 10.4 0.1 2.7 2 1 1 3 3 3 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Complex1_LYR_1 PF13232.1 EDK36028.1 - 1.5e-16 60.2 0.1 2e-16 59.9 0.1 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 EDK36028.1 - 6.7e-15 54.6 0.1 8.6e-15 54.2 0.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) adh_short PF00106.20 EDK36029.1 - 9e-19 68.0 0.0 1.4e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK36029.1 - 9.8e-17 61.5 0.1 1.2e-16 61.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK36029.1 - 7e-10 38.8 0.0 9.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK36029.1 - 0.0015 18.0 0.1 0.0033 16.8 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EDK36029.1 - 0.06 13.3 0.1 0.17 11.8 0.1 1.8 1 1 0 1 1 1 0 NADH(P)-binding TrkA_N PF02254.13 EDK36029.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 TrkA-N domain TRAPPC10 PF12584.3 EDK36030.2 - 3.1e-27 94.8 0.0 6.3e-27 93.8 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Sugar_tr PF00083.19 EDK36031.1 - 3.1e-23 82.0 12.2 8.8e-23 80.5 8.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK36031.1 - 6.7e-20 71.0 10.3 6.7e-20 71.0 7.2 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily O-antigen_lig PF13425.1 EDK36031.1 - 0.21 11.5 7.1 4.6 7.2 2.2 3.2 3 1 0 3 3 3 0 O-antigen ligase like membrane protein MFS_1 PF07690.11 EDK36032.1 - 6.3e-10 38.2 3.0 6.9e-10 38.1 1.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36032.1 - 7.6e-09 34.6 0.2 9.4e-09 34.3 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TauE PF01925.14 EDK36032.1 - 0.087 12.2 2.3 0.11 11.9 1.6 1.2 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Ni_hydr_CYTB PF01292.15 EDK36032.1 - 0.32 10.3 4.7 0.87 8.9 0.4 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Exo_endo_phos PF03372.18 EDK36033.2 - 2.1e-10 40.9 8.3 2.1e-10 40.9 4.4 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EDK36033.2 - 0.0059 16.2 3.0 0.018 14.6 0.1 2.8 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Calreticulin PF00262.13 EDK36034.2 - 5e-148 492.6 6.8 5e-148 492.6 4.7 1.4 2 0 0 2 2 2 1 Calreticulin family DUF4097 PF13349.1 EDK36034.2 - 0.03 13.8 0.1 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) Alb1 PF09135.6 EDK36035.2 - 9.3e-14 51.9 10.3 1.9e-13 50.9 4.7 2.1 2 0 0 2 2 2 1 Alb1 EMA PF02488.10 EDK36035.2 - 0.018 14.5 1.0 0.019 14.4 0.7 1.2 1 0 0 1 1 1 0 Merozoite Antigen CENP-B_dimeris PF09026.5 EDK36035.2 - 0.077 13.2 4.1 0.086 13.0 2.1 1.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain BSD PF03909.12 EDK36036.2 - 1.3e-27 95.3 6.8 9.1e-16 57.3 0.0 3.3 3 0 0 3 3 3 2 BSD domain TFIIH_BTF_p62_N PF08567.6 EDK36036.2 - 4.2e-24 83.9 0.1 9e-24 82.9 0.1 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain Coa1 PF08695.5 EDK36037.2 - 2.6e-40 136.5 0.0 3.6e-40 136.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SKG6 PF08693.5 EDK36038.2 - 0.00052 19.2 0.7 0.0019 17.4 0.5 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain YajC PF02699.10 EDK36038.2 - 0.033 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit EphA2_TM PF14575.1 EDK36038.2 - 0.036 14.4 0.0 0.085 13.2 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.1 EDK36038.2 - 0.062 13.0 0.5 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family Peptidase_M48 PF01435.13 EDK36039.2 - 8e-30 104.0 0.0 1.2e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 CoiA PF06054.6 EDK36040.2 - 0.023 13.5 0.0 0.027 13.3 0.0 1.1 1 0 0 1 1 1 0 Competence protein CoiA-like family Kin17_mid PF10357.4 EDK36041.2 - 8.2e-37 125.6 5.3 8.2e-37 125.6 3.7 2.2 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 EDK36041.2 - 2e-05 24.5 6.8 2e-05 24.5 4.7 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK36041.2 - 0.00013 22.0 5.0 0.0004 20.4 3.5 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EDK36041.2 - 0.0038 17.2 1.0 0.0038 17.2 0.7 2.6 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 EDK36041.2 - 0.042 13.6 0.4 0.042 13.6 0.2 3.2 1 1 1 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.1 EDK36041.2 - 0.15 12.4 2.4 0.35 11.2 1.6 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Myb_DNA-bind_3 PF12776.2 EDK36041.2 - 0.54 10.9 0.1 0.54 10.9 0.1 2.6 2 2 0 2 2 2 0 Myb/SANT-like DNA-binding domain UCH PF00443.24 EDK36042.2 - 4.6e-52 176.7 0.4 7.7e-52 176.0 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK36042.2 - 1.8e-26 93.2 0.6 5.7e-26 91.6 0.4 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-BED PF02892.10 EDK36042.2 - 0.00038 20.1 2.4 0.035 13.8 0.1 3.3 3 0 0 3 3 3 1 BED zinc finger zf-C2H2_4 PF13894.1 EDK36042.2 - 0.3 11.5 3.2 4.9 7.7 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Myb_DNA-binding PF00249.26 EDK36043.2 - 4.5e-30 103.4 9.5 1.5e-12 47.3 0.1 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK36043.2 - 4.3e-28 97.2 3.0 4.5e-11 42.6 0.0 3.8 3 1 1 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 EDK36043.2 - 0.00061 19.8 7.8 0.02 15.0 0.0 3.9 3 2 0 3 3 3 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.3 EDK36043.2 - 0.066 13.0 2.0 1.1 9.1 0.4 3.0 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain THF_DHG_CYH PF00763.18 EDK36044.2 - 7.6e-22 77.5 0.0 1.5e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 EDK36044.2 - 1.6e-19 69.5 0.1 2.3e-11 43.0 0.0 3.2 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.19 EDK36044.2 - 0.0026 18.0 0.0 0.0045 17.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RTP PF02334.11 EDK36044.2 - 0.098 12.6 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Replication terminator protein RabGAP-TBC PF00566.13 EDK36045.2 - 6.1e-45 153.3 7.2 4e-44 150.6 5.0 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain HSP70 PF00012.15 EDK36046.2 - 4.5e-79 265.9 6.6 4.5e-79 265.9 4.6 1.7 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 EDK36046.2 - 9.5e-09 34.2 0.4 1.5e-08 33.6 0.2 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Actin PF00022.14 EDK36046.2 - 4.5e-05 22.0 0.1 0.00015 20.2 0.0 1.7 1 1 0 2 2 2 1 Actin Exo_endo_phos PF03372.18 EDK36047.2 - 1.2e-07 31.9 0.1 3e-07 30.6 0.0 1.7 1 1 1 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RAI1 PF08652.6 EDK36048.2 - 0.039 13.7 0.8 0.11 12.3 0.0 2.2 2 1 0 2 2 2 0 RAI1 like PD-(D/E)XK nuclease Maf PF02545.9 EDK36049.2 - 2.2e-43 147.6 0.0 2.8e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein His_Phos_1 PF00300.17 EDK36050.2 - 1.1e-22 80.8 0.0 2.4e-22 79.7 0.0 1.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF572 PF04502.8 EDK36051.2 - 2.1e-63 214.5 16.0 2.7e-63 214.1 11.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Mut7-C PF01927.11 EDK36051.2 - 0.028 14.3 0.4 0.028 14.3 0.3 2.0 2 1 0 2 2 2 0 Mut7-C RNAse domain DUF342 PF03961.8 EDK36051.2 - 0.037 12.4 10.6 0.019 13.3 5.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Rapamycin_bind PF08771.6 EDK36051.2 - 0.074 13.1 1.9 0.19 11.8 1.3 1.7 1 0 0 1 1 1 0 Rapamycin binding domain Mu-like_Com PF10122.4 EDK36051.2 - 0.076 12.0 0.8 2.8 7.0 0.1 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com DUF2984 PF11203.3 EDK36051.2 - 0.12 12.4 1.4 0.16 12.1 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2984) Rhamno_transf PF11316.3 EDK36051.2 - 0.15 11.2 1.7 0.18 11.0 0.3 1.7 2 0 0 2 2 2 0 Putative rhamnosyl transferase E7 PF00527.13 EDK36051.2 - 0.3 11.2 0.1 0.3 11.2 0.1 3.0 2 1 0 2 2 1 0 E7 protein, Early protein zinc_ribbon_5 PF13719.1 EDK36051.2 - 0.38 10.3 4.3 11 5.7 0.3 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EDK36051.2 - 0.56 9.9 4.7 14 5.4 0.4 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-FPG_IleRS PF06827.9 EDK36051.2 - 1.4 8.6 4.5 13 5.5 0.1 2.8 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS DUF883 PF05957.8 EDK36051.2 - 2.9 8.3 6.6 6.1 7.3 4.3 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) 2-oxoacid_dh PF00198.18 EDK36052.2 - 3.7e-75 252.1 0.1 4.8e-75 251.7 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EDK36052.2 - 1.2e-16 60.0 0.0 2.3e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 EDK36052.2 - 1.2e-14 53.5 0.2 1.2e-14 53.5 0.1 1.9 2 0 0 2 2 2 1 e3 binding domain Rep-A_N PF04057.7 EDK36052.2 - 0.063 13.0 0.1 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain RNase_HII PF01351.13 EDK36053.2 - 6.5e-51 172.8 0.0 8.1e-51 172.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Mito_carr PF00153.22 EDK36054.2 - 8.9e-63 208.0 0.0 3.6e-21 74.6 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein MA3 PF02847.12 EDK36054.2 - 0.092 12.4 0.0 0.46 10.2 0.0 2.1 1 1 1 2 2 2 0 MA3 domain Syja_N PF02383.13 EDK36055.2 - 7.1e-87 291.1 0.3 1.5e-86 290.0 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.18 EDK36055.2 - 1.4e-24 87.3 0.0 3e-24 86.3 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.11 EDK36056.1 - 1.4e-31 108.0 1.0 2.4e-31 107.3 0.7 1.4 1 0 0 1 1 1 1 YEATS family Sec23_trunk PF04811.10 EDK36058.2 - 1.4e-50 171.9 0.1 6.2e-49 166.5 0.0 2.1 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 EDK36058.2 - 5.7e-33 113.3 0.0 1.4e-32 112.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.10 EDK36058.2 - 6.7e-31 105.7 0.2 1.3e-30 104.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 EDK36058.2 - 1.5e-08 34.1 0.0 3.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.10 EDK36058.2 - 3.2e-08 33.0 1.2 7.2e-08 31.8 0.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger tRNA-synt_2 PF00152.15 EDK36059.2 - 2.8e-73 246.6 0.0 3.5e-73 246.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK36059.2 - 2.2e-08 33.8 0.0 3.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EDK36059.2 - 2.5e-06 26.8 0.3 0.00096 18.4 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 EDK36059.2 - 0.029 13.9 0.1 6.3 6.3 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) RasGEF PF00617.14 EDK36060.2 - 9.2e-40 136.3 2.8 2.8e-37 128.2 0.1 3.3 2 1 0 2 2 2 2 RasGEF domain RhoGAP PF00620.22 EDK36060.2 - 5.1e-39 133.3 0.0 1.8e-38 131.5 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.15 EDK36060.2 - 2.2e-15 56.6 0.5 1.8e-14 53.7 0.4 2.7 1 0 0 1 1 1 1 RasGEF N-terminal motif PH_9 PF15410.1 EDK36060.2 - 0.0057 16.7 0.4 0.32 11.1 0.0 3.4 4 0 0 4 4 4 1 Pleckstrin homology domain 60KD_IMP PF02096.15 EDK36061.2 - 5.3e-43 147.0 4.8 9.3e-43 146.1 3.3 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein PolyA_pol_arg_C PF12626.2 EDK36061.2 - 0.036 13.7 0.3 0.088 12.4 0.2 1.6 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus Thymidylate_kin PF02223.12 EDK36062.2 - 0.0001 21.7 0.1 0.00025 20.4 0.1 1.7 1 0 0 1 1 1 1 Thymidylate kinase ATP13 PF12921.2 EDK36062.2 - 0.009 15.3 0.2 0.13 11.6 0.1 2.5 1 1 1 2 2 2 1 Mitochondrial ATPase expression PPR_2 PF13041.1 EDK36062.2 - 0.01 15.7 0.4 1.2 9.1 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family TPR_6 PF13174.1 EDK36062.2 - 0.061 13.8 0.1 2.9 8.5 0.0 3.7 4 1 1 5 5 5 0 Tetratricopeptide repeat PPR PF01535.15 EDK36062.2 - 0.08 12.9 0.0 5.7 7.1 0.0 3.5 3 0 0 3 3 3 0 PPR repeat SMC_N PF02463.14 EDK36063.2 - 8.6e-14 51.2 45.9 2.8e-13 49.6 31.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EDK36063.2 - 1.1e-10 42.1 31.3 1.1e-10 42.1 21.7 5.9 1 1 0 2 2 1 1 AAA domain AAA_13 PF13166.1 EDK36063.2 - 7.9e-06 24.6 81.4 0.00039 19.0 12.2 5.6 3 2 2 6 6 6 4 AAA domain AAA_15 PF13175.1 EDK36063.2 - 2.1e-05 23.7 18.5 2.1e-05 23.7 12.8 3.8 1 1 0 3 3 2 1 AAA ATPase domain ADIP PF11559.3 EDK36063.2 - 0.00019 21.3 7.2 0.00019 21.3 5.0 7.0 3 2 4 8 8 8 2 Afadin- and alpha -actinin-Binding AAA_21 PF13304.1 EDK36063.2 - 0.00043 20.3 3.7 0.00043 20.3 2.6 5.1 3 2 2 5 5 4 2 AAA domain IncA PF04156.9 EDK36063.2 - 0.0014 18.2 5.2 0.0014 18.2 3.6 5.4 2 2 2 4 4 4 2 IncA protein DUF745 PF05335.8 EDK36063.2 - 0.0014 18.1 7.0 0.0014 18.1 4.8 5.7 5 1 1 6 6 6 1 Protein of unknown function (DUF745) SbcCD_C PF13558.1 EDK36063.2 - 0.0029 17.4 0.0 0.012 15.5 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Laminin_II PF06009.7 EDK36063.2 - 0.0076 16.0 59.7 0.3 10.8 1.1 7.2 4 2 4 8 8 8 4 Laminin Domain II AAA_29 PF13555.1 EDK36063.2 - 0.016 14.7 0.0 0.038 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_C74 PF12387.3 EDK36063.2 - 0.046 12.8 0.2 4.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Pestivirus NS2 peptidase ABC_tran PF00005.22 EDK36063.2 - 0.086 13.1 0.1 0.086 13.1 0.1 5.1 4 2 0 4 4 3 0 ABC transporter Fib_alpha PF08702.5 EDK36063.2 - 1.1 9.4 59.8 0.055 13.5 1.9 6.5 4 2 2 6 6 6 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 EDK36063.2 - 3.7 7.3 47.0 0.095 12.4 2.2 6.9 4 2 3 7 7 7 0 Protein of unknown function (DUF1664) NUP PF06516.6 EDK36064.2 - 6e-123 409.6 0.0 7.1e-123 409.4 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) NUP PF06516.6 EDK36065.2 - 8.4e-132 438.7 0.0 1e-131 438.4 0.0 1.1 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) Amidohydro_1 PF01979.15 EDK36066.2 - 1.8e-43 149.4 0.1 2.3e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 EDK36066.2 - 5.4e-06 25.8 0.0 0.0056 15.9 0.0 2.4 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_4 PF13147.1 EDK36066.2 - 8.5e-05 22.7 0.0 0.1 12.6 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase Amidohydro_5 PF13594.1 EDK36066.2 - 0.0017 18.1 0.0 0.0046 16.7 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase CFEM PF05730.6 EDK36067.1 - 1.5e-09 37.5 13.4 1.5e-09 37.5 9.3 2.1 2 1 0 2 2 2 1 CFEM domain Plasmodium_Vir PF05795.6 EDK36067.1 - 2 7.5 8.5 2.5 7.1 5.9 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Hid1 PF12722.2 EDK36067.1 - 2.1 5.8 10.5 2.5 5.6 7.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Herpes_TAF50 PF03326.8 EDK36067.1 - 3 6.6 16.8 4.1 6.2 11.7 1.3 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) DUF1631 PF07793.6 EDK36067.1 - 3.3 5.7 7.4 3.6 5.5 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Hex_IIIa PF02455.11 EDK36067.1 - 9.6 4.7 9.5 13 4.2 6.6 1.2 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF1182 PF06681.8 EDK36069.2 - 0.14 11.3 0.1 0.34 10.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1182) Rogdi_lz PF10259.4 EDK36070.2 - 1.7e-95 319.2 0.6 2.1e-95 318.9 0.4 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein RskA PF10099.4 EDK36071.2 - 0.011 15.4 0.9 0.027 14.2 0.6 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA FAR1 PF03101.10 EDK36071.2 - 0.54 10.8 6.1 3.9 8.0 0.9 3.2 3 0 0 3 3 3 0 FAR1 DNA-binding domain Peptidase_M16 PF00675.15 EDK36072.2 - 6.5e-40 136.3 0.3 1.5e-39 135.1 0.2 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EDK36072.2 - 2.6e-23 82.6 0.1 2.8e-16 59.7 0.0 2.4 2 0 0 2 2 2 2 Peptidase M16 inactive domain Sec1 PF00995.18 EDK36073.2 - 2.6e-119 399.4 17.7 3e-119 399.2 12.3 1.0 1 0 0 1 1 1 1 Sec1 family Sod_Fe_C PF02777.13 EDK36074.2 - 7.7e-33 112.5 0.2 1.2e-32 111.8 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EDK36074.2 - 5.8e-25 87.3 0.2 1e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.2 EDK36074.2 - 0.041 13.7 0.0 0.33 10.8 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif Annexin PF00191.15 EDK36074.2 - 0.11 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Annexin MFS_1 PF07690.11 EDK36075.2 - 8.8e-21 74.0 49.7 3e-19 68.9 32.6 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2976 PF11190.3 EDK36075.2 - 0.0007 19.0 2.1 0.45 10.0 0.5 4.0 2 1 1 3 3 3 1 Protein of unknown function (DUF2976) PHD PF00628.24 EDK36076.2 - 2.6e-09 36.6 3.5 2.6e-09 36.6 2.4 1.8 2 0 0 2 2 2 1 PHD-finger UPF0184 PF03670.8 EDK36076.2 - 0.064 13.4 1.5 0.27 11.4 1.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) PHD_2 PF13831.1 EDK36076.2 - 0.23 10.8 5.1 0.39 10.0 3.5 1.4 1 0 0 1 1 1 0 PHD-finger CRAL_TRIO PF00650.15 EDK36077.2 - 2.1e-40 137.7 0.0 3.2e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 EDK36077.2 - 3e-09 36.9 0.0 5.5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EDK36077.2 - 0.00039 20.4 0.6 0.0042 17.1 0.1 2.7 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Nup_retrotrp_bd PF10599.4 EDK36078.2 - 3.6e-06 27.5 19.1 3.6e-06 27.5 13.2 10.0 3 2 4 7 7 7 1 Retro-transposon transporting motif AMP-binding PF00501.23 EDK36079.2 - 1.3e-38 132.4 0.0 6.6e-21 74.1 0.0 4.0 3 1 0 3 3 3 3 AMP-binding enzyme PPR_2 PF13041.1 EDK36080.2 - 5.3e-13 48.7 2.4 0.00031 20.6 0.0 4.2 3 1 2 5 5 5 3 PPR repeat family PPR_3 PF13812.1 EDK36080.2 - 6.9e-13 47.7 0.3 0.00022 21.2 0.0 5.7 5 0 0 5 5 5 3 Pentatricopeptide repeat domain PPR PF01535.15 EDK36080.2 - 4.6e-12 45.0 1.7 0.0016 18.2 0.0 4.8 5 0 0 5 5 5 2 PPR repeat ATP13 PF12921.2 EDK36080.2 - 0.0013 18.0 1.1 0.023 14.0 0.3 2.9 2 1 0 2 2 2 1 Mitochondrial ATPase expression ERAP1_C PF11838.3 EDK36080.2 - 0.0039 16.4 0.1 0.0072 15.6 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain PPR_1 PF12854.2 EDK36080.2 - 0.04 13.3 0.7 33 4.0 0.0 3.6 3 0 0 3 3 3 0 PPR repeat TPR_3 PF07720.7 EDK36080.2 - 0.053 13.3 0.1 48 3.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat tRNA-synt_1 PF00133.17 EDK36081.1 - 2.9e-46 157.6 1.3 3.2e-20 71.6 0.1 5.0 1 1 3 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 EDK36081.1 - 1.9e-45 154.4 0.0 2.8e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 EDK36081.1 - 1.1e-23 83.6 0.0 3.8e-21 75.1 0.0 3.0 2 1 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EDK36081.1 - 0.0049 16.0 0.0 0.008 15.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 EDK36081.1 - 0.0096 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) CNRIP1 PF15043.1 EDK36081.1 - 0.02 14.1 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 CB1 cannabinoid receptor-interacting protein 1 Apo-CIII PF05778.7 EDK36081.1 - 0.072 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) adh_short PF00106.20 EDK36083.2 - 2.8e-30 105.4 0.0 3.5e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK36083.2 - 6.6e-26 91.5 0.0 8.7e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK36083.2 - 1.3e-14 54.3 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EDK36083.2 - 0.0035 16.2 0.1 0.0049 15.8 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.5 EDK36083.2 - 0.0072 15.4 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Glyco_tran_WecB PF03808.8 EDK36083.2 - 0.051 12.9 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DegQ PF08181.6 EDK36083.2 - 0.088 12.5 0.1 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 DegQ (SacQ) family WD40 PF00400.27 EDK36084.2 - 7e-08 32.0 7.7 9e-07 28.5 0.2 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat YqzH PF14164.1 EDK36086.2 - 0.053 13.4 0.0 0.28 11.1 0.0 2.4 1 0 0 1 1 1 0 YqzH-like protein PspB PF06667.7 EDK36086.2 - 0.53 10.2 4.6 0.66 9.9 1.8 2.2 2 0 0 2 2 2 0 Phage shock protein B DUF4446 PF14584.1 EDK36086.2 - 3.2 7.5 10.3 0.73 9.6 2.4 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) RRM_1 PF00076.17 EDK36087.2 - 8.4e-14 50.9 0.6 5e-10 38.8 0.1 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36087.2 - 3.1e-11 43.0 0.1 3e-09 36.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36087.2 - 1.7e-09 37.3 0.1 0.002 17.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3573 PF12097.3 EDK36087.2 - 0.013 14.1 0.6 0.019 13.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) PWWP PF00855.12 EDK36087.2 - 0.043 14.0 1.0 0.043 14.0 0.7 1.9 2 0 0 2 2 2 0 PWWP domain Kri1 PF05178.7 EDK36087.2 - 0.57 10.4 10.2 0.091 13.0 0.6 3.1 2 1 0 2 2 2 0 KRI1-like family DUF1674 PF07896.7 EDK36088.2 - 1.3e-15 57.3 3.2 2e-15 56.7 2.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Vma12 PF11712.3 EDK36088.2 - 0.0095 15.6 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Methyltransf_16 PF10294.4 EDK36089.2 - 3.6e-19 68.8 0.0 6.4e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 EDK36089.2 - 2.1e-05 24.3 0.0 4.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK36089.2 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 EDK36089.2 - 0.17 10.9 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Aminotran_1_2 PF00155.16 EDK36090.2 - 1.4e-71 241.3 0.0 1.6e-71 241.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EDK36090.2 - 9.8e-06 24.8 0.0 1.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 EDK36090.2 - 2.4e-05 22.7 0.0 4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EDK36090.2 - 0.0027 16.5 0.0 0.0054 15.5 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V CLN3 PF02487.12 EDK36091.2 - 6.2e-101 338.1 23.0 2.5e-98 329.5 16.0 2.0 1 1 0 1 1 1 1 CLN3 protein MFS_1 PF07690.11 EDK36091.2 - 5.9e-05 21.9 4.4 5.9e-05 21.9 3.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily DAHP_synth_1 PF00793.15 EDK36092.1 - 1.9e-99 331.7 0.0 2.3e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family OMPdecase PF00215.19 EDK36092.1 - 0.015 14.6 0.1 0.03 13.7 0.1 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF218 PF02698.12 EDK36093.2 - 9.3e-06 25.2 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain HlyIII PF03006.15 EDK36094.1 - 7.2e-49 166.1 13.6 8.7e-49 165.9 9.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3278 PF11683.3 EDK36094.1 - 0.6 10.1 5.8 0.29 11.1 0.1 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3278) ABC2_membrane_5 PF13346.1 EDK36094.1 - 2.9 7.1 18.1 0.19 11.0 5.2 2.3 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF619 PF04768.8 EDK36095.2 - 2.9e-43 147.2 0.2 2.9e-43 147.2 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Sld5 PF05916.6 EDK36096.2 - 2e-18 66.6 0.3 3e-18 66.0 0.2 1.2 1 0 0 1 1 1 1 GINS complex protein HbrB PF08539.6 EDK36100.2 - 5.4e-05 23.0 0.5 0.00012 21.9 0.3 1.6 1 1 0 1 1 1 1 HbrB-like U-box PF04564.10 EDK36101.2 - 7.1e-20 70.7 0.0 1.6e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain TPR_11 PF13414.1 EDK36101.2 - 4.2e-08 32.7 8.8 3.7e-07 29.6 3.0 2.5 1 1 1 2 2 2 2 TPR repeat zf-Nse PF11789.3 EDK36101.2 - 0.019 14.4 0.1 0.048 13.1 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TPR_16 PF13432.1 EDK36101.2 - 0.044 14.4 0.0 0.48 11.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Tap-RNA_bind PF09162.5 EDK36101.2 - 0.076 12.5 0.0 0.24 10.9 0.0 1.9 1 0 0 1 1 1 0 Tap, RNA-binding TPR_1 PF00515.23 EDK36101.2 - 0.13 11.9 13.7 0.68 9.6 0.3 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 EDK36101.2 - 0.13 12.4 0.2 0.13 12.4 0.1 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EDK36101.2 - 0.21 11.6 8.5 5.2 7.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Chitin_synth_1 PF01644.12 EDK36102.2 - 4.1e-83 277.0 1.4 7e-83 276.3 0.9 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EDK36102.2 - 1.1e-25 89.0 0.4 3.7e-25 87.4 0.1 2.2 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EDK36102.2 - 9.9e-22 77.0 0.0 2.2e-21 75.8 0.0 1.5 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 EDK36102.2 - 5.8e-11 42.4 0.1 1.1e-10 41.5 0.1 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EDK36102.2 - 1.8e-06 27.9 0.0 5e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 MethyltransfD12 PF02086.10 EDK36103.1 - 0.034 13.6 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase RCC1 PF00415.13 EDK36104.2 - 4.1e-65 215.8 0.4 1.9e-12 47.1 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EDK36104.2 - 7.2e-35 117.8 25.1 5e-08 32.3 0.0 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Rcd1 PF04078.8 EDK36105.1 - 5.8e-123 408.8 2.1 6.9e-123 408.6 1.4 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like MatE PF01554.13 EDK36106.2 - 2e-62 209.5 26.9 7.7e-32 110.1 6.4 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 EDK36106.2 - 2.4e-06 27.3 6.2 2.4e-06 27.3 4.3 4.0 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Bystin PF05291.6 EDK36107.2 - 1.9e-124 414.4 1.0 2.4e-124 414.1 0.3 1.3 1 1 0 1 1 1 1 Bystin Ribosomal_S2 PF00318.15 EDK36107.2 - 0.018 14.3 0.1 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S2 PI-PLC-X PF00388.14 EDK36108.2 - 1.8e-51 173.4 0.0 4e-51 172.2 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 EDK36108.2 - 8.4e-43 145.1 0.1 2.1e-42 143.8 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 EDK36108.2 - 3.2e-07 30.0 0.0 8.7e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.6 EDK36108.2 - 2.3e-05 24.3 0.9 8.5e-05 22.5 0.4 2.2 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like GP40 PF11025.3 EDK36108.2 - 0.9 9.0 5.8 0.12 11.9 1.0 1.7 2 0 0 2 2 2 0 Glycoprotein GP40 of Cryptosporidium His_biosynth PF00977.16 EDK36109.2 - 4.1e-44 150.5 0.1 3e-43 147.7 0.1 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 EDK36109.2 - 9.1e-24 83.9 0.1 1.4e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.9 EDK36109.2 - 2e-05 24.2 0.0 3.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 EDK36109.2 - 0.0027 17.3 0.0 0.34 10.5 0.0 2.4 2 0 0 2 2 2 1 SNO glutamine amidotransferase family NMO PF03060.10 EDK36109.2 - 0.0095 15.1 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.9 EDK36109.2 - 0.024 13.7 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Peptidase_S51 PF03575.12 EDK36109.2 - 0.024 14.3 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 Peptidase family S51 Methyltransf_23 PF13489.1 EDK36110.2 - 0.00058 19.6 0.0 0.0027 17.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36110.2 - 0.004 17.6 0.0 0.012 16.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain RCR PF12273.3 EDK36111.1 - 1.1e-17 64.8 2.7 1.6e-17 64.2 1.8 1.3 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red GRP PF07172.6 EDK36111.1 - 0.0002 21.7 0.1 0.00032 21.1 0.0 1.3 1 0 0 1 1 1 1 Glycine rich protein family DUF1183 PF06682.7 EDK36111.1 - 0.0014 18.3 0.2 0.0016 18.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) BatD PF13584.1 EDK36111.1 - 0.002 16.8 0.2 0.0024 16.5 0.1 1.1 1 0 0 1 1 1 1 Oxygen tolerance CcmH PF03918.9 EDK36111.1 - 0.0088 15.0 0.1 0.013 14.5 0.1 1.2 1 0 0 1 1 1 1 Cytochrome C biogenesis protein WBP-1 PF11669.3 EDK36111.1 - 0.0094 16.0 0.1 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 WW domain-binding protein 1 ABC_membrane PF00664.18 EDK36111.1 - 0.016 14.6 0.3 0.021 14.2 0.2 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region EphA2_TM PF14575.1 EDK36111.1 - 0.025 14.9 0.0 0.04 14.3 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain FA_desaturase PF00487.19 EDK36111.1 - 0.038 13.4 2.7 0.048 13.0 1.9 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF2207 PF09972.4 EDK36111.1 - 0.054 12.0 0.5 0.068 11.7 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4381 PF14316.1 EDK36111.1 - 0.079 13.0 1.1 0.12 12.4 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TMEM156 PF15106.1 EDK36111.1 - 0.095 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 TMEM156 protein family DUF4131 PF13567.1 EDK36111.1 - 0.13 11.6 1.6 0.22 10.9 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3753 PF12575.3 EDK36111.1 - 0.15 11.8 0.3 0.21 11.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) SKG6 PF08693.5 EDK36111.1 - 2.1 7.7 4.2 3 7.2 2.9 1.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain AA_permease_2 PF13520.1 EDK36112.2 - 2.9e-48 164.4 39.0 3.6e-48 164.1 27.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK36112.2 - 3.3e-15 55.4 29.7 4.5e-15 54.9 20.6 1.1 1 0 0 1 1 1 1 Amino acid permease Phosphodiest PF01663.17 EDK36113.2 - 6.8e-18 65.1 0.7 4.4e-16 59.1 0.5 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 EDK36113.2 - 4.7e-07 29.4 0.0 8.1e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 EDK36113.2 - 6.4e-05 22.2 0.0 0.0071 15.5 0.0 2.2 1 1 1 2 2 2 2 Sulfatase zf-C2H2_2 PF12756.2 EDK36114.2 - 6.5e-34 116.0 5.3 4.7e-31 106.9 0.3 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) AAA_13 PF13166.1 EDK36114.2 - 0.036 12.5 4.1 0.066 11.6 2.8 1.4 1 0 0 1 1 1 0 AAA domain zf-C2H2_jaz PF12171.3 EDK36114.2 - 0.047 13.8 2.6 0.047 13.8 1.8 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.7 EDK36114.2 - 0.1 12.3 3.8 0.22 11.2 0.3 2.6 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Sipho_Gp157 PF05565.6 EDK36114.2 - 0.17 11.4 5.9 0.35 10.4 4.1 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 DHDPS PF00701.17 EDK36115.2 - 2.7e-34 118.0 0.0 3.1e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.1 EDK36115.2 - 0.072 12.2 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Glyco_hydro_88 PF07470.8 EDK36116.2 - 2.5e-13 49.7 1.2 1.5e-12 47.2 0.7 1.8 1 1 0 1 1 1 1 Glycosyl Hydrolase Family 88 DUF1680 PF07944.7 EDK36116.2 - 3.4e-06 25.6 0.2 4e-05 22.0 0.0 2.2 1 1 1 2 2 2 1 Putative glycosyl hydrolase of unknown function (DUF1680) C5-epim_C PF06662.8 EDK36116.2 - 8.6e-05 21.9 3.1 0.44 9.7 0.0 3.1 2 1 1 3 3 3 2 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.6 EDK36116.2 - 0.00028 20.0 0.1 0.00059 18.9 0.0 1.4 1 1 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) LANC_like PF05147.8 EDK36116.2 - 0.02 13.4 0.5 2.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Lanthionine synthetase C-like protein Fungal_trans PF04082.13 EDK36117.2 - 9e-63 211.5 2.4 1.6e-62 210.7 1.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.1 EDK36117.2 - 0.00084 19.5 6.2 0.0061 16.8 0.4 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.21 EDK36117.2 - 0.0011 19.1 6.7 0.005 17.1 0.3 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type Aldo_ket_red PF00248.16 EDK36118.1 - 6.2e-21 74.4 0.0 7.1e-21 74.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DNA_pol_A_exo1 PF01612.15 EDK36119.2 - 2e-45 154.4 0.3 4.1e-45 153.3 0.1 1.7 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.7 EDK36119.2 - 5.4e-24 84.3 7.0 1.3e-23 83.0 1.0 3.2 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.18 EDK36119.2 - 1.6e-07 30.9 0.0 7.6e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 HRDC domain MFS_1 PF07690.11 EDK36120.2 - 7.6e-29 100.5 17.1 7.6e-29 100.5 11.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36120.2 - 7.3e-05 21.5 7.0 7.3e-05 21.5 4.9 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter Oxidored_FMN PF00724.15 EDK36121.2 - 2.7e-92 309.4 0.0 3e-92 309.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Cyclin PF08613.6 EDK36122.2 - 1.5e-35 122.7 0.1 2.8e-35 121.9 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 EDK36122.2 - 0.00047 19.7 0.0 0.00089 18.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Metallophos PF00149.23 EDK36123.2 - 3.2e-39 134.4 1.0 4.5e-39 133.9 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MoCF_biosynth PF00994.19 EDK36124.2 - 3.6e-27 94.5 0.0 6.4e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain tRNA-synt_2c PF01411.14 EDK36125.1 - 1.5e-222 739.8 0.1 3.7e-222 738.5 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 EDK36125.1 - 4e-18 65.0 0.3 1.4e-17 63.3 0.2 2.0 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 EDK36125.1 - 2.7e-06 26.9 1.3 7.1e-06 25.6 0.9 1.8 1 0 0 1 1 1 1 DHHA1 domain Copper-fist PF00649.13 EDK36126.2 - 2e-21 74.9 0.6 4.4e-21 73.7 0.4 1.7 1 0 0 1 1 1 1 Copper fist DNA binding domain HSF_DNA-bind PF00447.12 EDK36127.2 - 1.7e-34 118.1 2.3 1.7e-34 118.1 1.6 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding DUF3320 PF11784.3 EDK36127.2 - 0.076 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) Fungal_trans_2 PF11951.3 EDK36128.2 - 3.8e-39 134.3 0.0 5.5e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK36128.2 - 6.2e-07 29.2 12.5 1.2e-06 28.2 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3260 PF11658.3 EDK36128.2 - 0.077 11.1 0.4 0.13 10.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) PAT1 PF09770.4 EDK36128.2 - 0.65 8.1 21.6 0.91 7.6 15.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pyr_redox_3 PF13738.1 EDK36129.2 - 2.6e-10 40.6 0.0 3.5e-05 23.9 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK36129.2 - 1.1e-07 31.0 0.0 1.6e-05 24.0 0.0 2.4 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EDK36129.2 - 1e-06 28.6 0.3 0.059 13.1 0.0 3.4 3 1 1 4 4 4 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EDK36129.2 - 2e-05 24.6 0.0 0.36 10.6 0.0 3.2 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EDK36129.2 - 0.00024 21.2 0.0 0.011 15.8 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 EDK36129.2 - 0.013 15.7 0.8 7.4 6.8 0.1 2.8 2 2 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox PF00070.22 EDK36129.2 - 0.068 13.5 6.7 0.23 11.8 0.0 3.2 3 1 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EDK36129.2 - 0.085 11.7 1.5 8.1 5.2 0.9 2.8 3 1 0 3 3 3 0 FAD dependent oxidoreductase TrkA_N PF02254.13 EDK36129.2 - 0.097 12.6 0.1 0.97 9.4 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_3 PF01494.14 EDK36129.2 - 0.16 10.9 0.1 10 5.0 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain DUF326 PF03860.11 EDK36129.2 - 6.1 6.8 7.4 20 5.1 1.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) Dak1 PF02733.12 EDK36130.2 - 8.7e-119 395.8 1.9 1.2e-118 395.4 1.3 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 EDK36130.2 - 5.7e-46 156.3 0.0 1.1e-45 155.4 0.0 1.5 1 0 0 1 1 1 1 DAK2 domain DNA_pol3_delta PF06144.8 EDK36130.2 - 0.34 10.3 1.5 0.35 10.3 0.0 1.7 2 0 0 2 2 2 0 DNA polymerase III, delta subunit Fungal_trans_2 PF11951.3 EDK36131.2 - 1.7e-100 336.3 0.9 2.4e-100 335.8 0.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK36131.2 - 2.9e-10 39.8 3.5 5.3e-10 39.0 2.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flocculin_t3 PF13928.1 EDK36133.1 - 1e-13 51.1 41.9 1.5e-10 40.9 16.5 4.2 4 0 0 4 4 4 2 Flocculin type 3 repeat UCR_TM PF02921.9 EDK36133.1 - 2.9 8.2 8.0 0.39 10.9 1.4 2.5 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region ERO1 PF04137.10 EDK36134.2 - 8.4e-110 367.1 0.2 1.1e-109 366.7 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DEAD PF00270.24 EDK36135.2 - 1.2e-47 161.5 0.0 2.5e-46 157.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK36135.2 - 3.9e-29 100.3 0.0 1.4e-27 95.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Hom_end_hint PF05203.11 EDK36135.2 - 2.4e-05 24.1 0.6 2.8e-05 23.9 0.4 1.2 1 0 0 1 1 1 1 Hom_end-associated Hint AAA_11 PF13086.1 EDK36135.2 - 0.00013 21.6 10.9 0.00021 20.9 5.8 2.3 2 1 1 3 3 3 1 AAA domain SAPS PF04499.10 EDK36135.2 - 0.015 13.9 8.0 0.02 13.5 5.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1253 PF06862.7 EDK36135.2 - 0.018 13.4 0.1 0.018 13.4 0.1 4.2 3 2 0 3 3 2 0 Protein of unknown function (DUF1253) CMS1 PF14617.1 EDK36135.2 - 0.033 13.2 0.1 0.033 13.2 0.0 3.3 2 1 0 2 2 1 0 U3-containing 90S pre-ribosomal complex subunit Otopetrin PF03189.8 EDK36135.2 - 0.053 12.5 0.3 0.06 12.3 0.2 1.2 1 0 0 1 1 1 0 Otopetrin Mem_trans PF03547.13 EDK36135.2 - 0.06 11.6 0.5 0.063 11.5 0.3 1.1 1 0 0 1 1 1 0 Membrane transport protein MIP-T3 PF10243.4 EDK36135.2 - 0.44 8.9 45.3 0.57 8.5 31.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Tim54 PF11711.3 EDK36135.2 - 0.63 8.5 18.6 0.33 9.5 11.1 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF966 PF06136.8 EDK36135.2 - 1.1 8.6 19.9 1.7 8.0 13.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DDRGK PF09756.4 EDK36135.2 - 1.2 8.4 36.4 2.5 7.4 25.2 1.4 1 0 0 1 1 1 0 DDRGK domain HSP90 PF00183.13 EDK36135.2 - 1.8 6.8 27.4 2.6 6.3 19.0 1.2 1 0 0 1 1 1 0 Hsp90 protein Pox_Ag35 PF03286.9 EDK36135.2 - 4.1 6.8 30.1 9.5 5.6 20.9 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2413 PF10310.4 EDK36135.2 - 4.2 6.0 29.8 6.8 5.3 20.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Tfb4 PF03850.9 EDK36135.2 - 4.7 6.3 5.4 9.8 5.3 3.7 1.5 1 0 0 1 1 1 0 Transcription factor Tfb4 NARP1 PF12569.3 EDK36135.2 - 5.1 5.7 31.1 7.5 5.1 21.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TFIIF_alpha PF05793.7 EDK36135.2 - 5.3 5.3 38.9 7.9 4.7 27.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) UCH_1 PF13423.1 EDK36137.2 - 1.5e-42 146.0 0.0 2.1e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 EDK36137.2 - 5.9e-27 94.9 0.0 9.3e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Exonuclease UCH PF00443.24 EDK36137.2 - 1.9e-11 43.6 0.1 4.1e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase eIF2A PF08662.6 EDK36137.2 - 0.12 12.0 0.0 0.52 9.9 0.0 2.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ribosomal_L40e PF01020.12 EDK36137.2 - 0.52 9.9 4.0 0.28 10.8 0.7 2.1 2 0 0 2 2 2 0 Ribosomal L40e family TCO89 PF10452.4 EDK36138.2 - 5.2e-13 48.7 64.0 1.9e-08 33.7 1.7 3.8 1 1 3 4 4 4 3 TORC1 subunit TCO89 Adaptin_N PF01602.15 EDK36139.2 - 7.6e-98 328.1 10.4 1.2e-97 327.4 7.2 1.3 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 EDK36139.2 - 1.7e-47 161.0 3.1 1.7e-47 161.0 2.1 2.5 3 0 0 3 3 3 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 EDK36139.2 - 2.4e-10 40.5 0.6 0.0056 16.9 0.0 5.2 3 3 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EDK36139.2 - 0.00064 20.1 4.9 4.4 7.9 0.3 4.3 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.17 EDK36139.2 - 0.25 11.4 9.4 2.5 8.4 0.0 5.9 7 0 0 7 7 7 0 HEAT repeat OPT PF03169.10 EDK36140.2 - 2.4e-180 601.0 43.3 2.8e-180 600.8 30.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Atx10homo_assoc PF09759.4 EDK36141.2 - 8.2e-36 121.8 1.2 3e-35 120.0 0.8 2.0 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.1 EDK36141.2 - 0.0041 17.3 0.1 0.066 13.5 0.0 2.7 3 0 0 3 3 3 1 HEAT repeats Thr_synth_N PF14821.1 EDK36142.2 - 1.1e-29 102.1 0.0 3e-29 100.8 0.0 1.8 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 EDK36142.2 - 9.5e-22 77.6 0.0 1.5e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Mmp37 PF09139.6 EDK36143.2 - 1.2e-99 333.5 0.0 1.6e-99 333.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 Gti1_Pac2 PF09729.4 EDK36144.2 - 3.5e-38 131.1 0.4 4e-31 108.1 0.0 2.3 1 1 1 2 2 2 2 Gti1/Pac2 family SAP30_Sin3_bdg PF13867.1 EDK36145.2 - 4.2e-09 36.1 0.3 1e-08 34.8 0.1 1.8 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 CUE PF02845.11 EDK36146.2 - 8.1e-10 37.9 0.0 1.4e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain WD40 PF00400.27 EDK36147.2 - 1.2e-34 116.8 12.7 2e-07 30.6 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EDK36147.2 - 1.2e-06 28.4 0.1 0.011 15.4 0.0 4.3 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 EDK36147.2 - 0.0011 17.8 0.1 0.5 9.0 0.0 2.8 2 1 0 2 2 2 2 Coatomer WD associated region M-inducer_phosp PF06617.8 EDK36147.2 - 0.023 13.7 0.9 0.039 13.0 0.6 1.4 1 0 0 1 1 1 0 M-phase inducer phosphatase Sen15 PF09631.5 EDK36147.2 - 0.06 13.5 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Sen15 protein PD40 PF07676.7 EDK36147.2 - 0.16 11.6 5.0 16 5.2 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Peptidase_M18 PF02127.10 EDK36148.2 - 4.9e-125 417.4 0.0 5.7e-125 417.1 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 EDK36148.2 - 0.006 15.3 0.1 0.055 12.2 0.0 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Sugar_tr PF00083.19 EDK36149.2 - 7.5e-89 298.3 18.0 8.9e-89 298.1 12.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK36149.2 - 1.1e-27 96.7 22.7 2.5e-18 65.9 0.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily SNARE PF05739.14 EDK36150.2 - 4.2e-05 23.1 1.0 4.2e-05 23.1 0.7 2.8 3 0 0 3 3 3 1 SNARE domain Ribosomal_L7Ae PF01248.21 EDK36151.1 - 4.8e-28 96.5 0.2 1.6e-27 94.8 0.1 1.7 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1907 PF08925.6 EDK36152.2 - 0.095 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) Adaptin_N PF01602.15 EDK36153.2 - 7.5e-100 334.7 12.1 1.3e-99 333.9 8.4 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 EDK36153.2 - 6.6e-62 206.9 0.0 1.7e-61 205.6 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 EDK36153.2 - 2.1e-53 179.7 1.3 2.1e-53 179.7 0.9 2.4 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 EDK36153.2 - 6.4e-14 52.0 4.2 2.5e-07 30.8 0.0 5.0 2 1 3 5 5 5 4 HEAT repeats HEAT PF02985.17 EDK36153.2 - 2.9e-07 29.9 0.5 0.0061 16.5 0.0 5.5 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 EDK36153.2 - 7.9e-06 26.2 0.3 0.67 10.5 0.0 5.6 5 1 1 6 6 6 1 HEAT-like repeat Cnd1 PF12717.2 EDK36153.2 - 0.00038 20.3 13.1 0.18 11.6 0.0 5.2 3 2 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 AP4E_app_platf PF14807.1 EDK36153.2 - 0.027 14.7 0.0 0.094 12.9 0.0 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Peptidase_M24 PF00557.19 EDK36154.1 - 1.1e-18 67.6 0.0 1.1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PHD PF00628.24 EDK36155.2 - 8.1e-10 38.2 36.5 6.7e-07 28.8 11.7 3.0 2 1 1 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.1 EDK36155.2 - 0.00014 21.9 10.7 0.033 14.3 1.4 2.5 2 0 0 2 2 2 2 PHD-like zinc-binding domain L51_S25_CI-B8 PF05047.11 EDK36156.1 - 1.9e-10 40.2 0.0 3e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ArgJ PF01960.13 EDK36157.2 - 4.6e-150 499.3 4.4 5.1e-150 499.1 3.0 1.0 1 0 0 1 1 1 1 ArgJ family PCRF PF03462.13 EDK36157.2 - 0.14 11.8 0.1 4.6 6.9 0.0 2.5 2 1 0 2 2 2 0 PCRF domain POT1 PF02765.12 EDK36158.2 - 0.01 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Telomeric single stranded DNA binding POT1/CDC13 adh_short PF00106.20 EDK36159.2 - 1.4e-26 93.3 0.2 6.2e-26 91.2 0.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK36159.2 - 3.3e-09 36.8 0.0 4.9e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK36159.2 - 3.2e-06 26.9 0.3 5.5e-05 22.8 0.2 2.1 1 1 0 1 1 1 1 KR domain PALP PF00291.20 EDK36159.2 - 0.029 13.6 0.0 0.098 11.8 0.0 1.7 1 1 1 2 2 2 0 Pyridoxal-phosphate dependent enzyme LpxC PF03331.8 EDK36159.2 - 0.047 12.6 0.0 0.082 11.8 0.0 1.3 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase DUF1762 PF08574.5 EDK36160.2 - 3.5e-22 78.5 14.5 3.5e-22 78.5 10.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1762) RNA_pol PF00940.14 EDK36161.2 - 2e-131 438.2 0.1 3.6e-131 437.3 0.1 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 EDK36161.2 - 1.6e-15 57.1 0.0 3.4e-13 49.5 0.0 2.5 1 1 1 2 2 2 2 DNA-directed RNA polymerase N-terminal TRAPP PF04051.11 EDK36162.2 - 8.6e-40 135.7 0.0 1.1e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component RRM_1 PF00076.17 EDK36163.2 - 3.5e-14 52.1 0.0 7.9e-11 41.4 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36163.2 - 3.7e-09 36.4 0.0 6.4e-07 29.2 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 EDK36164.2 - 8.9e-43 146.3 0.0 1.2e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36164.2 - 1.9e-25 89.4 0.0 4e-25 88.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36164.2 - 8.3e-07 28.2 0.1 1.9e-05 23.7 0.0 2.6 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK36164.2 - 0.0039 16.2 0.0 0.0071 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SUR7 PF06687.7 EDK36165.1 - 4.6e-39 134.1 12.1 5.4e-39 133.9 8.4 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EDK36165.1 - 0.00037 20.4 4.1 0.00063 19.6 2.8 1.4 1 0 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 Claudin_2 PF13903.1 EDK36165.1 - 0.095 12.3 14.6 0.065 12.9 8.5 2.0 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF3446 PF11928.3 EDK36165.1 - 0.32 11.2 3.7 0.68 10.1 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3446) RSN1_TM PF13967.1 EDK36165.1 - 0.4 10.2 4.0 0.41 10.1 1.5 2.0 2 1 1 3 3 3 0 Late exocytosis, associated with Golgi transport DUF1469 PF07332.6 EDK36165.1 - 0.85 9.3 18.4 3 7.5 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1469) DUF4064 PF13273.1 EDK36165.1 - 3.9 7.6 11.2 1.4 9.0 1.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) DUF2256 PF10013.4 EDK36166.2 - 0.028 14.1 0.9 0.028 14.1 0.6 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Haemocyan_bet_s PF14830.1 EDK36166.2 - 0.057 13.1 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Haemocyanin beta-sandwich Plasmodium_Vir PF05795.6 EDK36167.1 - 0.02 14.1 2.0 6.7 5.8 0.1 3.3 1 1 1 3 3 3 0 Plasmodium vivax Vir protein MF_alpha_N PF05436.6 EDK36167.1 - 0.039 13.6 0.4 0.086 12.5 0.2 1.6 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus TB2_DP1_HVA22 PF03134.14 EDK36167.1 - 1.8 8.3 6.1 83 3.0 0.0 4.1 1 1 2 4 4 4 0 TB2/DP1, HVA22 family ARGLU PF15346.1 EDK36169.2 - 0.43 10.3 14.6 0.2 11.4 8.5 1.6 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 RNase_H PF00075.19 EDK36170.1 - 1.4e-20 73.9 0.0 2e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 RNase H GCP5-Mod21 PF14609.1 EDK36171.2 - 0.022 12.8 0.1 0.031 12.4 0.1 1.1 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 Pex24p PF06398.6 EDK36171.2 - 0.11 11.2 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin UCR_Fe-S_N PF10399.4 EDK36171.2 - 0.14 11.3 0.2 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF2651 PF10852.3 EDK36171.2 - 1.5 9.2 6.2 3 8.2 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2651) Rab5ip PF07019.7 EDK36171.2 - 5.5 7.1 8.7 44 4.2 6.1 2.1 1 1 0 1 1 1 0 Rab5-interacting protein (Rab5ip) Tetraspannin PF00335.15 EDK36172.2 - 0.0039 16.4 0.0 0.0045 16.2 0.0 1.1 1 0 0 1 1 1 1 Tetraspanin family UPF0239 PF06783.6 EDK36172.2 - 0.012 15.5 1.9 0.082 12.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) LXG PF04740.7 EDK36173.2 - 0.045 13.5 1.0 0.084 12.6 0.7 1.4 1 0 0 1 1 1 0 LXG domain of WXG superfamily RasGAP_C PF03836.10 EDK36173.2 - 0.059 13.0 0.7 0.11 12.2 0.5 1.4 1 0 0 1 1 1 0 RasGAP C-terminus DUF972 PF06156.8 EDK36173.2 - 0.073 13.4 1.6 0.081 13.2 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 EDK36173.2 - 0.1 13.3 0.7 0.34 11.6 0.5 1.8 1 0 0 1 1 1 0 Occludin homology domain Ndc1_Nup PF09531.5 EDK36173.2 - 0.17 10.2 4.7 0.24 9.7 3.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mnd1 PF03962.10 EDK36173.2 - 0.47 10.0 4.8 0.15 11.7 1.4 1.5 2 0 0 2 2 2 0 Mnd1 family RRF_GI PF12614.3 EDK36173.2 - 0.5 10.1 3.4 1.2 8.9 0.6 2.3 2 1 0 2 2 2 0 Ribosome recycling factor IncA PF04156.9 EDK36173.2 - 5.4 6.5 7.4 0.59 9.6 1.7 1.8 2 0 0 2 2 2 0 IncA protein HTH_41 PF14502.1 EDK36174.2 - 0.14 11.8 0.0 0.48 10.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain SH3_1 PF00018.23 EDK36175.2 - 1.2e-07 31.0 0.0 2.8e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK36175.2 - 1.7e-07 30.7 0.1 5e-07 29.1 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 EDK36175.2 - 1.7e-06 27.4 0.0 4.5e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.13 EDK36175.2 - 6.5e-05 22.5 2.3 6.5e-05 22.5 1.6 1.9 2 0 0 2 2 2 1 BAR domain DUF3571 PF12095.3 EDK36175.2 - 0.075 13.2 0.1 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3571) ATG16 PF08614.6 EDK36175.2 - 5 6.9 12.1 2.2 8.0 0.6 3.3 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Abhydrolase_1 PF00561.15 EDK36176.2 - 8.2e-16 58.2 0.0 1.7e-15 57.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK36176.2 - 8.2e-10 38.9 0.0 1.1e-09 38.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK36176.2 - 1.3e-06 28.2 0.0 3e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EDK36176.2 - 0.00094 18.9 0.0 0.0027 17.5 0.0 1.8 1 0 0 1 1 1 1 Putative lysophospholipase HEAT PF02985.17 EDK36177.2 - 6.8e-09 35.0 0.7 0.0022 17.9 0.0 4.3 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.1 EDK36177.2 - 1.4e-08 34.8 0.0 0.00027 21.1 0.0 3.5 4 0 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EDK36177.2 - 9.7e-08 32.2 0.9 0.097 13.1 0.0 5.2 5 1 0 5 5 5 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EDK36177.2 - 0.0001 22.5 0.0 0.031 14.6 0.0 3.4 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region Arm PF00514.18 EDK36177.2 - 0.00022 20.8 0.4 13 5.8 0.0 4.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat DUF3349 PF11829.3 EDK36177.2 - 0.0076 16.6 0.0 0.1 13.0 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3349) MtlR PF05068.7 EDK36178.2 - 0.0097 15.3 0.1 0.091 12.2 0.0 2.3 2 0 0 2 2 2 1 Mannitol repressor HEAT PF02985.17 EDK36178.2 - 0.62 10.3 3.5 18 5.7 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat GLE1 PF07817.8 EDK36179.2 - 7.1e-85 284.0 1.4 7.1e-85 284.0 0.9 2.0 2 0 0 2 2 2 1 GLE1-like protein CAF-1_p150 PF11600.3 EDK36179.2 - 0.0083 15.5 31.8 0.016 14.5 22.0 1.4 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal ARGLU PF15346.1 EDK36179.2 - 0.01 15.5 36.1 0.021 14.5 25.0 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 BTV_NS2 PF04514.7 EDK36179.2 - 0.011 14.6 17.5 0.016 14.0 12.1 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Asp-B-Hydro_N PF05279.6 EDK36179.2 - 0.72 9.6 17.2 1.1 9.0 11.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GAGA_bind PF06217.7 EDK36179.2 - 2.1 8.2 10.5 3.8 7.3 7.3 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family GBP_C PF02841.9 EDK36179.2 - 4.2 6.4 26.2 6.9 5.7 18.2 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain LCD1 PF09798.4 EDK36179.2 - 4.9 5.0 16.4 6.8 4.5 11.4 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein Vfa1 PF08432.5 EDK36179.2 - 9 6.2 21.0 18 5.2 14.6 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ribosomal_L5_C PF00673.16 EDK36180.2 - 3.8e-25 87.4 0.0 6e-25 86.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus DUF2439 PF10382.4 EDK36181.2 - 9.1e-26 89.8 0.0 1.4e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) GGDEF PF00990.16 EDK36181.2 - 0.048 13.2 0.0 0.076 12.5 0.0 1.2 1 0 0 1 1 1 0 GGDEF domain zf-C2H2 PF00096.21 EDK36183.2 - 3.1e-05 24.0 3.0 3.1e-05 24.0 2.1 3.8 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK36183.2 - 0.015 15.5 1.7 0.015 15.5 1.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger TPR_16 PF13432.1 EDK36184.2 - 4.9e-08 33.4 0.0 0.00014 22.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36184.2 - 9e-07 28.9 0.2 0.059 14.0 0.0 5.0 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 EDK36184.2 - 0.00015 20.9 1.3 0.024 13.7 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 EDK36184.2 - 0.00076 19.2 1.6 0.006 16.4 0.3 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36184.2 - 0.00092 19.5 0.0 11 6.4 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 EDK36184.2 - 0.0011 18.6 1.0 0.047 13.4 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 EDK36184.2 - 0.0047 16.6 2.6 0.026 14.3 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat NRDE-2 PF08424.5 EDK36184.2 - 0.0088 14.9 1.7 3 6.6 0.0 3.0 3 0 0 3 3 3 2 NRDE-2, necessary for RNA interference TPR_12 PF13424.1 EDK36184.2 - 0.0099 15.7 1.1 0.094 12.6 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EDK36184.2 - 0.014 15.0 0.2 1.6 8.4 0.1 3.0 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.1 EDK36184.2 - 0.031 14.4 0.2 6.1 7.3 0.0 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 EDK36184.2 - 0.033 14.6 0.3 63 4.3 0.0 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Apc3 PF12895.2 EDK36184.2 - 0.037 14.1 7.3 1.2 9.3 0.1 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Brix PF04427.13 EDK36184.2 - 0.066 12.8 1.0 0.13 11.8 0.0 1.9 2 1 0 2 2 2 0 Brix domain HAT PF02184.11 EDK36184.2 - 0.48 10.2 7.9 6.1 6.6 0.1 3.7 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Na_Ca_ex PF01699.19 EDK36185.2 - 4.3e-29 100.8 37.1 3.3e-18 65.6 9.4 2.9 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Flavokinase PF01687.12 EDK36186.2 - 3.7e-35 120.5 0.0 4.5e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Peptidase_C48 PF02902.14 EDK36187.2 - 9.5e-36 123.4 0.1 2.2e-35 122.2 0.1 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain RNA12 PF10443.4 EDK36188.2 - 1.3e-152 508.2 1.1 3.2e-152 506.9 0.3 1.9 2 1 0 2 2 2 1 RNA12 protein Arch_ATPase PF01637.13 EDK36188.2 - 0.00013 21.7 0.6 0.0013 18.4 0.4 2.3 1 1 0 1 1 1 1 Archaeal ATPase RRM_1 PF00076.17 EDK36188.2 - 0.0046 16.5 0.0 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.24 EDK36189.2 - 8.7e-37 126.2 0.0 1.4e-36 125.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK36189.2 - 1.3e-06 28.5 0.3 0.0024 17.8 0.0 2.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.1 EDK36189.2 - 6.6e-06 26.0 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EDK36189.2 - 7.4e-06 26.1 0.3 0.0051 16.9 0.0 3.1 1 1 2 3 3 3 1 AAA domain RuvB_N PF05496.7 EDK36189.2 - 9.7e-06 24.7 0.0 2.6e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EDK36189.2 - 4.2e-05 24.3 0.0 0.00012 22.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EDK36189.2 - 5.9e-05 23.0 0.0 0.00013 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EDK36189.2 - 8.5e-05 22.4 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EDK36189.2 - 0.0002 21.0 0.1 0.0023 17.6 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 EDK36189.2 - 0.0008 18.8 0.0 0.002 17.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 EDK36189.2 - 0.00089 18.4 0.1 0.0023 17.1 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EDK36189.2 - 0.0012 18.9 0.0 0.0048 17.0 0.0 2.1 2 1 0 2 2 1 1 RNA helicase AAA_25 PF13481.1 EDK36189.2 - 0.0012 18.2 0.5 0.092 12.1 0.1 2.3 1 1 1 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 EDK36189.2 - 0.0014 18.6 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 EDK36189.2 - 0.0014 17.7 0.0 0.0024 17.0 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Parvo_NS1 PF01057.12 EDK36189.2 - 0.0022 16.9 0.0 0.0032 16.3 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 NACHT PF05729.7 EDK36189.2 - 0.0023 17.6 0.3 0.023 14.3 0.1 2.3 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.1 EDK36189.2 - 0.0082 16.4 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 EDK36189.2 - 0.0085 14.8 0.1 0.021 13.5 0.0 1.6 1 1 0 1 1 1 1 TIP49 C-terminus Arch_ATPase PF01637.13 EDK36189.2 - 0.013 15.2 0.1 0.17 11.5 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase DUF815 PF05673.8 EDK36189.2 - 0.014 14.3 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.1 EDK36189.2 - 0.017 14.7 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 EDK36189.2 - 0.023 13.5 0.0 0.051 12.4 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_28 PF13521.1 EDK36189.2 - 0.032 14.1 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EDK36189.2 - 0.037 13.7 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Part of AAA domain ABC_tran PF00005.22 EDK36189.2 - 0.042 14.1 0.0 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.21 EDK36189.2 - 0.043 13.2 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_10 PF12846.2 EDK36189.2 - 0.052 12.9 0.2 0.53 9.6 0.0 2.3 2 1 1 3 3 3 0 AAA-like domain AAA_23 PF13476.1 EDK36189.2 - 0.056 13.7 0.0 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EDK36189.2 - 0.069 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.13 EDK36189.2 - 0.091 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein ResIII PF04851.10 EDK36189.2 - 0.11 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_21 PF13304.1 EDK36189.2 - 0.11 12.4 1.3 8.2 6.2 0.1 2.7 2 1 0 3 3 3 0 AAA domain MIF4G PF02854.14 EDK36190.2 - 1.1e-22 80.5 2.5 1.3e-20 73.6 0.9 2.8 2 0 0 2 2 2 2 MIF4G domain MA3 PF02847.12 EDK36190.2 - 5.9e-19 67.8 0.1 3e-18 65.5 0.0 2.2 2 0 0 2 2 2 1 MA3 domain tRNA_U5-meth_tr PF05958.6 EDK36191.2 - 1.5e-18 66.6 0.1 2.3e-18 66.0 0.1 1.3 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 EDK36191.2 - 1.6e-11 44.0 0.1 7e-11 41.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36191.2 - 5.6e-08 33.3 0.0 6.2e-07 29.9 0.0 2.6 2 1 1 3 3 3 1 Methyltransferase domain MTS PF05175.9 EDK36191.2 - 3.9e-06 26.3 0.0 8.6e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 EDK36191.2 - 5.9e-06 26.0 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein TRAM PF01938.15 EDK36191.2 - 7.3e-06 25.6 0.1 2.1e-05 24.2 0.1 1.8 1 0 0 1 1 1 1 TRAM domain Methyltransf_32 PF13679.1 EDK36191.2 - 1e-05 25.2 0.0 5.1e-05 22.9 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36191.2 - 1.2e-05 25.2 0.0 3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EDK36191.2 - 3.5e-05 23.4 0.1 9.4e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.8 EDK36191.2 - 6.7e-05 22.1 0.0 0.00014 21.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.13 EDK36191.2 - 0.00084 18.5 0.0 0.0023 17.1 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EDK36191.2 - 0.0018 18.5 0.0 0.011 16.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36191.2 - 0.0022 18.4 0.1 0.026 15.0 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36191.2 - 0.0042 17.5 0.1 0.02 15.3 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EDK36191.2 - 0.021 13.9 0.0 0.053 12.5 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.14 EDK36191.2 - 0.066 12.7 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SMC_N PF02463.14 EDK36192.2 - 5.8e-62 208.7 8.9 2.2e-61 206.8 6.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EDK36192.2 - 8.4e-28 96.7 0.0 3.3e-27 94.8 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EDK36192.2 - 1.2e-13 51.8 17.9 1.2e-13 51.8 12.4 6.4 3 2 3 6 6 6 1 AAA domain AAA_21 PF13304.1 EDK36192.2 - 8.1e-10 39.1 30.8 3e-07 30.7 0.7 4.6 3 2 1 4 4 4 2 AAA domain AAA_29 PF13555.1 EDK36192.2 - 3.6e-07 29.6 0.0 8.2e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Baculo_PEP_C PF04513.7 EDK36192.2 - 0.054 13.3 33.7 1.6 8.5 0.8 6.4 5 2 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran PF00005.22 EDK36192.2 - 4 7.7 25.6 13 6.1 0.0 6.1 3 3 1 4 4 4 0 ABC transporter Creatinase_N PF01321.13 EDK36193.2 - 9e-16 58.5 0.0 2.4e-13 50.7 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain DUF148 PF02520.12 EDK36193.2 - 0.048 13.4 1.4 0.12 12.1 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF3020 PF11223.3 EDK36194.2 - 3.2e-20 72.2 7.6 3.2e-20 72.2 5.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3020) Phage_connect_1 PF05135.8 EDK36194.2 - 8 6.7 10.8 3.8 7.7 0.1 4.0 2 1 1 4 4 4 0 Phage gp6-like head-tail connector protein DUF1769 PF08588.5 EDK36195.1 - 1.3e-26 92.3 0.2 2.4e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Transaldolase PF00923.14 EDK36196.2 - 5.9e-98 327.5 1.1 6.7e-98 327.3 0.7 1.0 1 0 0 1 1 1 1 Transaldolase VTC PF09359.5 EDK36197.2 - 6.8e-89 297.6 3.2 1.1e-88 296.8 2.2 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 EDK36197.2 - 5.6e-19 68.9 23.1 2e-11 44.1 6.0 3.9 2 2 2 4 4 4 2 SPX domain DUF202 PF02656.10 EDK36197.2 - 3.1e-09 36.9 2.9 3.1e-09 36.9 2.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Clat_adaptor_s PF01217.15 EDK36198.2 - 2.4e-16 59.7 0.5 3e-16 59.4 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Tfb4 PF03850.9 EDK36198.2 - 0.0062 15.8 1.2 0.0081 15.4 0.8 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 DUF2706 PF10913.3 EDK36198.2 - 0.056 13.0 0.1 0.097 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) TAF1_subA PF14929.1 EDK36198.2 - 0.069 11.6 0.3 0.085 11.2 0.2 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A TES PF08034.6 EDK36198.2 - 0.13 12.3 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Trematode eggshell synthesis protein PTR2 PF00854.16 EDK36199.2 - 1.4e-46 158.9 12.4 2.2e-46 158.3 8.6 1.2 1 0 0 1 1 1 1 POT family Bromo_TP PF07524.8 EDK36200.2 - 2.7e-07 30.2 0.0 4.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated Exo5 PF09810.4 EDK36202.2 - 1e-36 126.8 0.0 3.9e-36 124.9 0.0 1.9 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 EDK36202.2 - 1.2e-06 28.1 0.0 1e-05 25.0 0.0 2.1 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Sugar_tr PF00083.19 EDK36203.2 - 1.1e-86 291.2 25.9 1.3e-86 290.9 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK36203.2 - 1e-30 106.6 28.4 1e-30 106.6 19.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK36203.2 - 0.0028 15.9 2.9 0.0028 15.9 2.0 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Viral_P18 PF04521.8 EDK36203.2 - 0.13 11.6 0.2 0.27 10.7 0.1 1.5 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein DcpS_C PF11969.3 EDK36204.2 - 5.1e-31 107.3 3.7 7e-31 106.8 2.6 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 EDK36204.2 - 2.8e-14 53.4 0.7 4.6e-14 52.7 0.5 1.3 1 0 0 1 1 1 1 HIT domain zf-BED PF02892.10 EDK36204.2 - 0.031 14.0 0.1 0.066 12.9 0.1 1.5 1 0 0 1 1 1 0 BED zinc finger Pkr1 PF08636.5 EDK36205.1 - 7.1e-32 109.3 6.2 8.4e-32 109.0 4.3 1.1 1 0 0 1 1 1 1 ER protein Pkr1 O-antigen_lig PF13425.1 EDK36205.1 - 0.0086 16.0 0.1 0.011 15.7 0.1 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Papilloma_E5A PF05776.7 EDK36205.1 - 0.039 14.1 0.8 0.05 13.7 0.6 1.1 1 0 0 1 1 1 0 Papillomavirus E5A protein zf-RING_4 PF14570.1 EDK36206.2 - 4.8e-16 58.0 7.4 9.7e-16 57.0 5.1 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_5 PF13893.1 EDK36206.2 - 4.9e-09 35.9 0.0 1e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK36206.2 - 1.3e-08 34.2 0.0 3.8e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.6 EDK36206.2 - 0.00054 19.7 2.1 0.0014 18.3 1.4 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) RRM_6 PF14259.1 EDK36206.2 - 0.002 18.0 0.0 0.0061 16.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 EDK36206.2 - 0.004 16.8 2.9 0.004 16.8 2.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK36206.2 - 0.052 13.2 4.5 0.13 11.9 3.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4187 PF13821.1 EDK36206.2 - 0.19 11.3 2.1 0.36 10.4 0.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4187) Anticodon_1 PF08264.8 EDK36207.1 - 3.6e-16 59.2 0.2 6.6e-16 58.4 0.1 1.5 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.9 EDK36207.1 - 3.6e-05 23.2 4.4 6.3e-05 22.5 3.0 1.4 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS Sp100 PF03172.8 EDK36207.1 - 0.076 12.9 0.2 2.9 7.9 0.0 2.4 1 1 1 2 2 2 0 Sp100 domain tRNA-synt_1 PF00133.17 EDK36208.2 - 1e-154 515.8 0.2 1.4e-154 515.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EDK36208.2 - 1.4e-22 79.9 0.5 2.5e-12 46.1 0.0 3.8 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 EDK36208.2 - 0.001 18.4 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1f PF01921.13 EDK36208.2 - 0.024 13.3 0.0 0.043 12.4 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_1e PF01406.14 EDK36208.2 - 0.027 13.5 0.0 2.4 7.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Citrate_synt PF00285.16 EDK36209.1 - 7.8e-101 337.3 0.0 8.8e-101 337.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase DSPc PF00782.15 EDK36210.2 - 2.8e-28 98.1 0.0 5.4e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EDK36210.2 - 0.001 18.4 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Yippee-Mis18 PF03226.9 EDK36210.2 - 0.012 15.6 0.7 0.38 10.8 0.8 2.7 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PTPlike_phytase PF14566.1 EDK36210.2 - 0.095 12.7 0.0 0.58 10.2 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.7 EDK36210.2 - 0.11 11.2 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase zinc_ribbon_5 PF13719.1 EDK36210.2 - 0.22 11.1 3.3 9.1 5.9 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EDK36210.2 - 0.49 10.1 4.1 12 5.6 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 EDK36210.2 - 1.1 9.0 5.7 5.5 6.8 1.2 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain UPF0547 PF10571.4 EDK36210.2 - 2.6 7.8 5.6 5.3 6.8 0.0 2.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Apc15p PF05841.6 EDK36211.2 - 2.2e-21 76.8 2.1 3e-21 76.4 0.2 1.9 2 0 0 2 2 2 1 Apc15p protein DUF2392 PF10288.4 EDK36212.2 - 1.7e-30 105.5 0.1 3.2e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) ATP_bind_3 PF01171.15 EDK36212.2 - 9.8e-05 21.9 0.1 0.086 12.3 0.0 2.4 2 0 0 2 2 2 2 PP-loop family COX17 PF05051.8 EDK36213.2 - 6.9e-05 22.7 2.0 0.0001 22.2 1.4 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 EDK36213.2 - 0.018 14.9 2.9 0.029 14.3 2.0 1.4 1 0 0 1 1 1 0 CHCH domain Pet191_N PF10203.4 EDK36213.2 - 0.15 12.0 5.3 0.39 10.7 3.5 1.7 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 PTN_MK_C PF01091.13 EDK36213.2 - 0.18 11.8 3.9 0.61 10.1 0.6 2.2 1 1 1 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain UPF0203 PF05254.7 EDK36213.2 - 0.4 10.5 5.3 1.8 8.4 3.7 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 EDK36213.2 - 0.69 9.7 5.6 2.1 8.2 1.0 1.9 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like PH PF00169.24 EDK36215.2 - 3.2e-12 46.5 0.0 9.6e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.23 EDK36215.2 - 1.7e-08 33.7 0.2 4.6e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EDK36215.2 - 2.6e-08 33.3 0.0 5.3e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.12 EDK36215.2 - 1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_11 PF15413.1 EDK36215.2 - 1.4e-07 31.7 1.2 1.1e-06 28.8 0.1 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.12 EDK36215.2 - 0.0015 17.9 0.0 0.0034 16.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Agenet PF05641.7 EDK36215.2 - 0.029 14.5 0.0 0.078 13.1 0.0 1.7 1 0 0 1 1 1 0 Agenet domain SAM_1 PF00536.25 EDK36215.2 - 0.037 14.1 0.1 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2000 PF09391.5 EDK36215.2 - 0.074 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) TPR_11 PF13414.1 EDK36216.2 - 1.9e-31 107.5 8.1 5.2e-12 45.2 0.1 7.6 6 3 2 8 8 8 5 TPR repeat TPR_2 PF07719.12 EDK36216.2 - 2.4e-31 105.0 0.2 5.5e-06 25.8 0.0 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.23 EDK36216.2 - 9.5e-31 104.1 1.1 5.1e-06 25.8 0.0 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat Apc3 PF12895.2 EDK36216.2 - 1.6e-25 89.0 11.7 1.7e-18 66.5 0.5 4.0 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EDK36216.2 - 5.2e-25 85.3 0.0 5.2e-06 25.8 0.0 7.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 EDK36216.2 - 4.8e-21 74.8 1.3 1.7e-06 28.5 0.2 7.2 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 EDK36216.2 - 3.4e-20 70.4 1.2 0.1 12.8 0.0 7.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 EDK36216.2 - 3.1e-19 68.6 1.4 7e-05 22.6 0.0 7.3 6 1 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36216.2 - 1e-12 47.4 0.1 0.018 15.6 0.4 7.2 6 1 2 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 EDK36216.2 - 3.7e-10 39.5 0.5 0.041 14.3 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 EDK36216.2 - 1.2e-09 37.2 0.4 1.4 8.8 0.0 7.4 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36216.2 - 3.6e-09 36.8 1.6 0.091 13.1 0.5 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 EDK36216.2 - 1.8e-08 34.1 0.0 0.0015 18.3 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF1039 PF06287.6 EDK36216.2 - 0.015 15.1 0.1 2.2 8.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1039) ChAPs PF09295.5 EDK36216.2 - 0.043 12.5 0.0 5.6 5.6 0.0 3.1 2 1 2 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.1 EDK36216.2 - 2.3 8.2 4.5 9.1 6.3 0.0 4.1 6 0 0 6 6 6 0 Tetratricopeptide repeat EMP70 PF02990.11 EDK36217.2 - 8.6e-117 390.7 6.8 8.6e-117 390.7 4.7 1.6 2 0 0 2 2 2 1 Endomembrane protein 70 ATP-synt PF00231.14 EDK36218.2 - 1.9e-68 230.9 4.4 2.2e-68 230.7 3.1 1.0 1 0 0 1 1 1 1 ATP synthase Phage_Gp14 PF10666.4 EDK36218.2 - 0.11 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Phage protein Gp14 Frag1 PF10277.4 EDK36219.2 - 1.3e-40 139.1 14.8 1.3e-40 139.1 10.3 3.1 4 0 0 4 4 4 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.18 EDK36219.2 - 6.9e-05 22.8 0.0 0.00014 21.8 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FUSC PF04632.7 EDK36219.2 - 0.0082 14.6 0.1 0.0082 14.6 0.1 2.3 1 1 1 2 2 2 1 Fusaric acid resistance protein family PDZ_1 PF12812.2 EDK36220.2 - 5.4e-47 157.5 0.0 9.4e-32 108.7 0.0 3.1 3 0 0 3 3 3 2 PDZ-like domain PDZ_2 PF13180.1 EDK36220.2 - 3.3e-19 68.5 0.5 3.8e-07 29.9 0.0 3.7 3 0 0 3 3 3 3 PDZ domain Trypsin_2 PF13365.1 EDK36220.2 - 1.8e-15 56.9 0.1 1e-12 48.0 0.0 3.0 3 0 0 3 3 3 1 Trypsin-like peptidase domain PDZ PF00595.19 EDK36220.2 - 4.7e-14 52.3 0.1 2.4e-07 30.8 0.0 3.7 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 EDK36220.2 - 5.9e-05 22.7 0.3 0.047 13.4 0.0 3.4 3 0 0 3 3 3 1 Tricorn protease PDZ domain Trypsin PF00089.21 EDK36220.2 - 8e-05 22.3 0.0 0.00035 20.2 0.0 2.0 1 1 0 1 1 1 1 Trypsin Peptidase_S7 PF00949.16 EDK36220.2 - 0.014 14.8 0.1 0.028 13.8 0.1 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF31 PF01732.11 EDK36220.2 - 0.035 13.4 0.3 0.081 12.2 0.2 1.6 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.4 EDK36220.2 - 0.082 11.3 0.6 0.34 9.2 0.1 1.9 2 0 0 2 2 2 0 Peptidase S46 ETC_C1_NDUFA4 PF04800.7 EDK36221.2 - 1.1e-27 95.8 0.6 1.7e-27 95.2 0.4 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region DUF1358 PF07096.6 EDK36221.2 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1358) ORC6 PF05460.8 EDK36222.2 - 5.2e-108 361.2 0.0 6e-108 361.1 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) N-SET PF11764.3 EDK36223.2 - 1.3e-51 174.7 1.3 1.3e-51 174.7 0.9 3.0 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.3 EDK36223.2 - 1.3e-25 88.4 1.9 2.7e-25 87.4 1.3 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated SET PF00856.23 EDK36223.2 - 2.9e-23 82.9 0.2 2.9e-23 82.9 0.1 3.8 3 3 0 3 3 3 1 SET domain MutS_V PF00488.16 EDK36224.2 - 4.6e-84 281.4 0.3 7.1e-84 280.8 0.2 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EDK36224.2 - 1.8e-31 109.5 0.0 8.6e-31 107.3 0.0 2.1 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EDK36224.2 - 1.7e-21 76.3 0.1 2.1e-20 72.8 0.0 2.5 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.12 EDK36224.2 - 3.1e-11 43.4 0.3 4e-10 39.8 0.0 2.4 2 0 0 2 2 2 1 MutS domain II AAA_29 PF13555.1 EDK36224.2 - 0.05 13.1 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gar1 PF04410.9 EDK36225.2 - 9.5e-46 155.0 2.2 1e-45 154.9 0.1 2.1 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region SUN PF03856.8 EDK36226.2 - 3e-105 351.0 17.6 3e-105 351.0 12.2 1.6 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) Macoilin PF09726.4 EDK36226.2 - 0.11 10.7 5.3 0.12 10.6 3.7 1.1 1 0 0 1 1 1 0 Transmembrane protein AA_permease PF00324.16 EDK36227.1 - 6.8e-119 397.3 47.2 8.2e-119 397.0 32.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK36227.1 - 4.8e-31 107.7 51.5 5.2e-31 107.6 35.2 1.4 1 1 0 1 1 1 1 Amino acid permease Reoviridae_Vp9 PF08978.5 EDK36227.1 - 0.032 13.1 0.1 0.092 11.6 0.0 1.7 1 0 0 1 1 1 0 Reoviridae VP9 CARDB PF07705.6 EDK36227.1 - 0.18 11.8 1.0 7.6 6.6 0.0 2.4 2 0 0 2 2 2 0 CARDB Eaf7 PF07904.8 EDK36229.2 - 5.3e-17 61.5 4.9 5.3e-17 61.5 3.4 2.2 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 TFIIF_alpha PF05793.7 EDK36229.2 - 0.009 14.4 41.4 0.011 14.1 28.7 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Lipl32 PF12103.3 EDK36229.2 - 2 7.8 7.6 2.9 7.2 4.7 1.8 1 1 1 2 2 2 0 Surface lipoprotein of Spirochaetales order S4 PF01479.20 EDK36230.1 - 3e-14 52.1 0.0 6.6e-14 51.0 0.0 1.6 1 0 0 1 1 1 1 S4 domain Methyltransf_26 PF13659.1 EDK36231.2 - 9.4e-13 48.2 0.0 1.9e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36231.2 - 1.2e-11 45.1 0.0 5.4e-11 43.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36231.2 - 7.9e-11 41.7 0.0 1.3e-10 41.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK36231.2 - 6.1e-10 38.7 0.0 1e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 EDK36231.2 - 6.4e-05 23.2 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EDK36231.2 - 0.00014 21.4 0.1 0.00038 20.0 0.0 1.7 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase N6_Mtase PF02384.11 EDK36231.2 - 0.00024 20.2 0.0 0.00037 19.6 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.8 EDK36231.2 - 0.00083 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 EDK36231.2 - 0.0013 18.3 0.0 0.004 16.7 0.0 1.8 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 EDK36231.2 - 0.0017 17.8 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_16 PF10294.4 EDK36231.2 - 0.0032 16.9 0.0 0.0065 15.9 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 EDK36231.2 - 0.0038 16.3 0.0 0.0061 15.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 EDK36231.2 - 0.0048 16.5 0.0 0.0077 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36231.2 - 0.0076 16.7 0.0 0.019 15.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 EDK36231.2 - 0.0095 15.5 0.0 0.03 13.8 0.0 1.8 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.1 EDK36231.2 - 0.0099 15.6 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36231.2 - 0.011 16.2 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 EDK36231.2 - 0.047 12.7 0.0 0.094 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_3 PF01596.12 EDK36231.2 - 0.06 12.3 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase HTH_Mga PF08280.6 EDK36231.2 - 0.062 13.0 0.1 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain AviRa PF11599.3 EDK36231.2 - 0.081 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Nol1_Nop2_Fmu PF01189.12 EDK36232.2 - 5.9e-107 357.2 0.0 1.4e-106 356.0 0.0 1.6 2 0 0 2 2 2 1 NOL1/NOP2/sun family FtsJ PF01728.14 EDK36232.2 - 0.0022 17.9 0.0 0.0055 16.7 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 EDK36232.2 - 0.0085 15.6 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Gcd10p PF04189.8 EDK36233.2 - 2.1e-101 338.9 0.2 2.6e-101 338.6 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family CAP_N PF01213.14 EDK36234.2 - 7.3e-95 317.8 3.8 1.1e-94 317.2 2.6 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 EDK36234.2 - 3.6e-55 185.6 4.0 5.4e-55 185.0 2.7 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Actin PF00022.14 EDK36235.2 - 1.9e-49 168.1 0.0 1.4e-28 99.4 0.0 2.2 2 0 0 2 2 2 2 Actin DnaJ PF00226.26 EDK36236.2 - 6.3e-28 96.2 2.8 1.1e-27 95.5 1.9 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EDK36236.2 - 7.8e-22 76.9 1.0 6.7e-18 64.3 0.0 2.8 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EDK36236.2 - 1.1e-12 47.7 21.0 1.9e-12 47.0 14.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Malate_DH PF12434.3 EDK36236.2 - 0.12 12.1 0.5 0.25 11.0 0.3 1.5 1 0 0 1 1 1 0 Malate dehydrogenase enzyme HypA PF01155.14 EDK36236.2 - 2.5 7.8 13.7 3.2 7.4 1.2 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family MFS_1 PF07690.11 EDK36237.2 - 3.9e-40 137.6 27.0 3.9e-40 137.6 18.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GLTP PF08718.6 EDK36238.2 - 0.12 12.4 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) PRK PF00485.13 EDK36239.2 - 2.2e-08 33.9 0.0 7.5e-08 32.1 0.0 1.8 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 EDK36239.2 - 5.8e-05 23.4 0.0 0.00015 22.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK36239.2 - 6.5e-05 23.7 0.0 0.0001 23.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK36239.2 - 0.037 13.5 0.0 0.089 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CPT PF07931.7 EDK36239.2 - 0.052 13.1 0.0 0.12 12.0 0.0 1.8 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.1 EDK36239.2 - 0.062 13.1 0.0 0.28 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain GNAT_acetyltr_2 PF13718.1 EDK36240.1 - 3.4e-83 277.8 0.0 1.2e-82 275.9 0.0 1.9 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 EDK36240.1 - 2.2e-66 222.8 0.0 1e-65 220.6 0.0 2.2 3 0 0 3 3 3 1 Helicase DUF1726 PF08351.6 EDK36240.1 - 1.8e-40 136.4 0.2 1.3e-39 133.7 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 EDK36240.1 - 2.4e-37 127.0 0.7 9.4e-37 125.1 0.5 2.1 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 EDK36240.1 - 0.00028 20.9 0.0 0.0019 18.3 0.0 2.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_19 PF13245.1 EDK36240.1 - 0.00094 18.8 0.0 0.63 9.8 0.0 3.3 3 0 0 3 3 3 1 Part of AAA domain AAA_22 PF13401.1 EDK36240.1 - 0.0053 16.8 0.0 0.65 10.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain DEAD PF00270.24 EDK36240.1 - 0.013 14.9 0.0 0.037 13.5 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase Acetyltransf_1 PF00583.19 EDK36240.1 - 0.039 13.9 0.0 0.17 11.9 0.0 2.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family NDT80_PhoG PF05224.7 EDK36241.2 - 4.8e-38 131.0 0.0 9e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family LSM PF01423.17 EDK36242.2 - 6.8e-16 57.5 0.6 9.5e-16 57.1 0.5 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EDK36242.2 - 0.12 12.3 0.1 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Gemin7 PF11095.3 EDK36242.2 - 0.15 11.7 0.0 0.38 10.5 0.0 1.6 2 0 0 2 2 2 0 Gem-associated protein 7 (Gemin7) C1_1 PF00130.17 EDK36243.2 - 0.016 14.9 2.5 0.34 10.6 0.3 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4201 PF13870.1 EDK36243.2 - 0.032 13.6 2.4 0.066 12.6 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF3287 PF11690.3 EDK36243.2 - 0.052 13.6 0.1 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) AAA_9 PF12781.2 EDK36243.2 - 0.052 12.3 0.2 0.075 11.8 0.1 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region D5 zinc_ribbon_5 PF13719.1 EDK36243.2 - 0.073 12.6 0.1 0.073 12.6 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain XH PF03469.9 EDK36243.2 - 0.093 12.3 3.5 0.1 12.2 0.3 2.3 1 1 1 2 2 2 0 XH domain zf-HC5HC2H_2 PF13832.1 EDK36243.2 - 0.095 12.7 2.4 0.9 9.5 0.3 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-FCS PF06467.9 EDK36243.2 - 0.099 12.3 6.0 0.28 10.8 0.5 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DZR PF12773.2 EDK36243.2 - 0.11 12.3 2.4 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 EDK36243.2 - 0.12 12.1 3.9 4.4 7.1 0.0 2.7 3 0 0 3 3 3 0 zinc-ribbons zinc_ribbon_4 PF13717.1 EDK36243.2 - 0.16 11.7 0.1 0.16 11.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.4 EDK36243.2 - 0.18 11.5 0.2 0.18 11.5 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Eapp_C PF10238.4 EDK36243.2 - 0.62 9.9 6.5 0.37 10.6 0.3 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein SlyX PF04102.7 EDK36243.2 - 0.69 10.3 2.9 1.9 8.8 0.2 2.6 2 1 0 2 2 2 0 SlyX Pneumo_phosprot PF02478.11 EDK36243.2 - 0.81 9.1 6.8 0.65 9.4 4.0 1.3 1 1 0 1 1 1 0 Pneumovirus phosphoprotein TMPIT PF07851.8 EDK36243.2 - 1.9 7.5 5.6 0.37 9.7 1.5 1.5 1 1 1 2 2 2 0 TMPIT-like protein Syntaxin PF00804.20 EDK36243.2 - 5.4 7.2 8.8 1 9.5 1.6 2.3 2 0 0 2 2 2 0 Syntaxin Zn_Tnp_IS1 PF03811.8 EDK36243.2 - 8.5 5.9 7.8 2.6 7.6 0.1 2.6 2 1 0 2 2 2 0 InsA N-terminal domain Rft-1 PF04506.8 EDK36244.2 - 3.4e-55 187.4 8.2 9e-55 186.0 5.7 1.6 1 1 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.1 EDK36244.2 - 1.3e-05 24.8 6.6 1.3e-05 24.8 4.6 2.5 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein CBFD_NFYB_HMF PF00808.18 EDK36245.2 - 1.9e-26 91.8 0.0 3.1e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK36245.2 - 4e-06 26.8 0.0 7.6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 EDK36245.2 - 0.013 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated TFIID-18kDa PF02269.11 EDK36245.2 - 0.031 14.0 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit TraO PF10626.4 EDK36245.2 - 0.12 11.7 0.1 0.27 10.6 0.0 1.6 2 0 0 2 2 2 0 Conjugative transposon protein TraO zf-RING_2 PF13639.1 EDK36246.2 - 8.7e-12 44.6 10.7 8.7e-12 44.6 7.4 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EDK36246.2 - 1.4e-07 31.0 12.1 3.3e-07 29.8 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK36246.2 - 1.5e-07 31.4 6.3 3.4e-07 30.2 4.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EDK36246.2 - 3.3e-06 27.0 10.4 1.1e-05 25.3 7.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK36246.2 - 7.3e-06 25.6 10.6 7.3e-06 25.6 7.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK36246.2 - 5.3e-05 22.8 7.0 5.3e-05 22.8 4.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK36246.2 - 0.0016 18.2 3.2 0.0044 16.8 2.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.1 EDK36246.2 - 0.071 13.2 5.5 0.044 13.9 2.4 1.8 2 0 0 2 2 1 0 PHD-like zinc-binding domain zf-C3HC4_4 PF15227.1 EDK36246.2 - 0.12 12.2 6.0 0.51 10.2 4.3 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 EDK36246.2 - 0.19 11.3 8.2 0.41 10.2 5.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Na_Ca_ex PF01699.19 EDK36246.2 - 0.41 10.2 9.0 0.32 10.6 1.2 2.4 2 0 0 2 2 2 0 Sodium/calcium exchanger protein FANCL_C PF11793.3 EDK36246.2 - 0.51 10.3 10.9 1.7 8.6 7.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_UBOX PF13445.1 EDK36246.2 - 1.9 8.2 8.9 0.22 11.2 1.7 2.7 2 1 1 3 3 3 0 RING-type zinc-finger RINGv PF12906.2 EDK36246.2 - 2 8.5 11.4 5.1 7.2 7.9 1.7 1 0 0 1 1 1 0 RING-variant domain Cortexin PF11057.3 EDK36246.2 - 4.5 6.9 10.7 5 6.7 0.0 4.1 4 0 0 4 4 4 0 Cortexin of kidney zf-RING-like PF08746.6 EDK36246.2 - 7.3 6.6 10.6 16 5.5 7.3 1.6 1 0 0 1 1 1 0 RING-like domain Nol1_Nop2_Fmu PF01189.12 EDK36247.2 - 2.2e-63 214.2 0.0 3.9e-49 167.5 0.0 2.2 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 EDK36247.2 - 0.0077 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF1887 PF09002.6 EDK36247.2 - 0.013 13.9 0.1 0.057 11.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1887) Methyltransf_26 PF13659.1 EDK36247.2 - 0.14 12.1 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Lon_C PF05362.8 EDK36248.2 - 1.2e-64 217.4 0.0 2.5e-64 216.3 0.0 1.6 2 0 0 2 2 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 EDK36248.2 - 2.1e-30 105.9 0.1 2.1e-30 105.9 0.1 2.1 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain AAA PF00004.24 EDK36248.2 - 3.3e-20 72.6 0.0 3.3e-20 72.6 0.0 2.1 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EDK36248.2 - 2.8e-07 30.3 0.0 8e-07 28.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.6 EDK36248.2 - 7.4e-06 24.8 0.0 1.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.7 EDK36248.2 - 1.8e-05 23.9 0.0 0.00055 19.0 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EDK36248.2 - 4.1e-05 24.4 0.2 0.00019 22.2 0.0 2.3 2 0 0 2 2 1 1 AAA domain ChlI PF13541.1 EDK36248.2 - 0.00012 21.5 0.0 0.00024 20.6 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.1 EDK36248.2 - 0.00015 21.9 0.1 0.009 16.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK36248.2 - 0.00017 21.6 0.0 0.00053 20.0 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 EDK36248.2 - 0.00029 20.5 0.1 0.00071 19.2 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 EDK36248.2 - 0.00034 19.4 0.4 0.0017 17.1 0.1 2.0 2 0 0 2 2 2 1 TIP49 C-terminus Zeta_toxin PF06414.7 EDK36248.2 - 0.00051 19.1 0.2 0.0018 17.4 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_14 PF13173.1 EDK36248.2 - 0.00055 19.8 0.0 0.0015 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EDK36248.2 - 0.0034 17.0 0.0 0.11 12.2 0.0 2.6 1 1 1 2 2 2 1 NTPase AAA_11 PF13086.1 EDK36248.2 - 0.0039 16.7 3.6 0.01 15.4 0.0 2.9 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.1 EDK36248.2 - 0.0061 16.8 0.0 0.0061 16.8 0.0 2.6 3 0 0 3 3 1 1 AAA domain IstB_IS21 PF01695.12 EDK36248.2 - 0.0063 15.9 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.6 EDK36248.2 - 0.0096 15.5 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 EDK36248.2 - 0.01 15.4 0.8 0.019 14.6 0.0 1.7 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 EDK36248.2 - 0.017 14.2 0.4 0.4 9.8 0.0 2.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EDK36248.2 - 0.024 14.5 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EDK36248.2 - 0.025 14.1 0.1 0.067 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EDK36248.2 - 0.043 13.2 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EDK36248.2 - 0.074 13.2 0.0 0.26 11.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 EDK36248.2 - 0.1 12.2 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 EDK36248.2 - 0.46 10.7 0.0 0.46 10.7 0.0 2.6 3 0 0 3 3 2 0 ABC transporter zf-UBR PF02207.15 EDK36249.2 - 3.7e-18 64.9 9.5 3.7e-18 64.9 6.6 2.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) MCM PF00493.18 EDK36250.2 - 5.3e-139 462.6 0.3 7.5e-139 462.1 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 EDK36250.2 - 3.8e-34 117.9 35.5 3.8e-34 117.9 24.6 2.7 3 0 0 3 3 3 2 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 EDK36250.2 - 5.9e-14 52.6 0.1 5.9e-14 52.6 0.1 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EDK36250.2 - 2.1e-08 33.6 0.0 3.5e-06 26.3 0.0 2.5 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EDK36250.2 - 4.4e-07 29.7 0.0 2.2e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EDK36250.2 - 0.00081 19.0 0.0 0.018 14.6 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK36250.2 - 0.0012 18.3 0.1 0.0062 16.0 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain ApoO PF09769.4 EDK36250.2 - 0.057 13.1 0.3 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 Apolipoprotein O Metallophos PF00149.23 EDK36251.2 - 0.069 12.5 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase DUF624 PF04854.9 EDK36253.1 - 0.01 15.6 1.5 0.021 14.6 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF624 Methyltransf_16 PF10294.4 EDK36254.1 - 1.1e-17 63.9 0.0 1.9e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 EDK36254.1 - 3.2e-06 26.9 0.1 6.6e-06 25.9 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36254.1 - 4.5e-06 27.2 0.0 6.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3883 PF13020.1 EDK36254.1 - 0.015 15.0 0.1 0.034 13.8 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3883) Methyltransf_31 PF13847.1 EDK36254.1 - 0.016 14.8 0.8 0.034 13.7 0.6 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36254.1 - 0.047 14.1 0.0 0.093 13.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF1237 PF06824.6 EDK36256.2 - 9.8e-181 600.9 0.0 1.2e-180 600.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) ATP_bind_1 PF03029.12 EDK36257.2 - 4.3e-83 278.4 0.1 7.5e-83 277.7 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 EDK36257.2 - 5.1e-07 29.3 0.9 3.8e-05 23.1 0.6 3.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EDK36257.2 - 3.8e-06 27.7 0.4 0.00023 21.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EDK36257.2 - 1.1e-05 25.3 0.0 2.8e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain ArgK PF03308.11 EDK36257.2 - 3e-05 22.9 0.1 0.042 12.6 0.0 2.4 2 0 0 2 2 2 2 ArgK protein AAA_22 PF13401.1 EDK36257.2 - 6.4e-05 23.1 0.0 0.00026 21.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain PduV-EutP PF10662.4 EDK36257.2 - 7.6e-05 22.2 0.1 0.0085 15.5 0.0 2.9 3 1 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 EDK36257.2 - 0.00062 19.4 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_10 PF12846.2 EDK36257.2 - 0.00091 18.7 2.6 0.012 15.1 1.6 2.2 1 1 0 1 1 1 1 AAA-like domain MMR_HSR1 PF01926.18 EDK36257.2 - 0.00099 19.0 0.6 0.0029 17.5 0.1 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase CbiA PF01656.18 EDK36257.2 - 0.0011 18.4 1.2 0.0016 17.8 0.0 1.9 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.1 EDK36257.2 - 0.0013 18.3 0.3 0.0041 16.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain Arf PF00025.16 EDK36257.2 - 0.0014 17.8 0.1 0.89 8.7 0.0 3.2 2 2 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.13 EDK36257.2 - 0.0014 17.8 0.0 0.081 12.1 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B SRP54 PF00448.17 EDK36257.2 - 0.0031 16.9 0.0 0.026 13.9 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 EDK36257.2 - 0.0039 17.1 0.0 0.0087 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 EDK36257.2 - 0.0086 16.3 5.4 0.011 15.9 0.0 3.2 3 1 0 3 3 3 1 AAA domain SRPRB PF09439.5 EDK36257.2 - 0.01 15.1 2.5 0.2 10.8 0.0 2.6 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit MobB PF03205.9 EDK36257.2 - 0.015 15.0 0.0 0.044 13.4 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 EDK36257.2 - 0.017 14.3 0.3 0.091 11.9 0.0 2.1 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Miro PF08477.8 EDK36257.2 - 0.027 14.9 1.0 3.5 8.1 0.0 2.7 3 0 0 3 3 2 0 Miro-like protein AAA_30 PF13604.1 EDK36257.2 - 0.033 13.7 0.0 0.084 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 EDK36257.2 - 0.033 13.3 0.0 0.6 9.2 0.0 2.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 cobW PF02492.14 EDK36257.2 - 0.035 13.5 0.3 0.29 10.5 0.2 2.3 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 EDK36257.2 - 0.059 13.1 0.6 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 ATP-synt_E PF05680.7 EDK36257.2 - 0.12 12.3 2.1 0.42 10.5 1.5 1.9 1 0 0 1 1 1 0 ATP synthase E chain DUF106 PF01956.11 EDK36258.1 - 5.6e-53 178.9 0.4 6.7e-53 178.6 0.3 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 DUF3767 PF12597.3 EDK36259.1 - 4e-46 155.4 0.3 7.1e-46 154.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) Cadherin_C PF01049.12 EDK36259.1 - 0.03 14.3 0.8 0.067 13.2 0.0 1.7 2 0 0 2 2 2 0 Cadherin cytoplasmic region DUF3353 PF11833.3 EDK36259.1 - 0.39 10.1 3.7 0.24 10.8 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3353) 4F5 PF04419.9 EDK36259.1 - 0.47 11.2 9.1 0.94 10.2 6.3 1.5 1 0 0 1 1 1 0 4F5 protein family AAA PF00004.24 EDK36260.2 - 1.2e-59 200.2 0.0 3.9e-43 146.8 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 EDK36260.2 - 6.6e-28 96.5 1.9 1.2e-27 95.7 0.2 2.4 2 0 0 2 2 2 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 EDK36260.2 - 1.5e-09 38.0 5.4 0.00041 20.3 0.1 3.9 3 2 1 4 4 4 2 AAA ATPase domain AAA_14 PF13173.1 EDK36260.2 - 3.3e-07 30.2 0.0 0.017 14.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EDK36260.2 - 3.5e-07 29.8 1.7 0.73 9.1 0.1 4.2 2 2 1 4 4 4 2 AAA domain AAA_17 PF13207.1 EDK36260.2 - 1.2e-06 29.3 0.2 0.028 15.2 0.0 3.5 3 1 0 4 4 3 2 AAA domain AAA_22 PF13401.1 EDK36260.2 - 1.3e-06 28.6 3.9 0.026 14.6 0.7 4.2 2 2 1 3 3 3 2 AAA domain NACHT PF05729.7 EDK36260.2 - 3.4e-06 26.8 4.3 0.0019 17.8 0.6 3.9 3 1 0 3 3 3 1 NACHT domain AAA_30 PF13604.1 EDK36260.2 - 1.5e-05 24.6 0.0 0.00012 21.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EDK36260.2 - 1.6e-05 24.3 0.2 0.059 12.7 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.22 EDK36260.2 - 1.9e-05 24.9 2.6 0.0032 17.7 0.1 3.1 3 0 0 3 3 2 1 ABC transporter Arch_ATPase PF01637.13 EDK36260.2 - 4.3e-05 23.3 0.5 0.11 12.1 0.0 3.8 2 2 1 3 3 3 1 Archaeal ATPase AAA_2 PF07724.9 EDK36260.2 - 7.7e-05 22.6 0.0 0.0099 15.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 EDK36260.2 - 0.00013 22.0 0.0 0.58 10.3 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_18 PF13238.1 EDK36260.2 - 0.00022 21.5 0.2 0.96 9.7 0.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EDK36260.2 - 0.00028 20.6 0.1 1.1 8.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EDK36260.2 - 0.001 18.2 0.0 0.27 10.2 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 EDK36260.2 - 0.0014 18.3 0.2 2.2 8.1 0.1 2.6 2 0 0 2 2 2 2 Part of AAA domain RuvB_N PF05496.7 EDK36260.2 - 0.0021 17.1 0.0 0.028 13.4 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Sigma54_activat PF00158.21 EDK36260.2 - 0.0035 16.8 0.0 0.95 8.9 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.1 EDK36260.2 - 0.0041 17.0 0.0 0.16 11.8 0.0 2.9 3 0 0 3 3 2 1 AAA domain DUF2075 PF09848.4 EDK36260.2 - 0.0041 16.1 0.0 1.5 7.6 0.0 2.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 EDK36260.2 - 0.02 14.4 2.4 4.3 6.8 0.2 2.7 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 EDK36260.2 - 0.02 14.0 0.2 3.8 6.5 0.0 2.7 2 1 0 2 2 2 0 KaiC AAA_29 PF13555.1 EDK36260.2 - 0.04 13.4 0.2 0.54 9.8 0.1 2.7 3 0 0 3 3 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.16 EDK36260.2 - 0.053 12.6 0.2 0.7 9.0 0.1 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PEX-2N PF09263.5 EDK36260.2 - 0.1 12.9 0.0 0.3 11.4 0.0 1.8 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal AAA_10 PF12846.2 EDK36260.2 - 0.14 11.6 2.6 0.48 9.8 0.0 2.7 3 0 0 3 3 3 0 AAA-like domain Sld5 PF05916.6 EDK36261.2 - 3.1e-17 62.8 1.5 5.1e-17 62.1 1.0 1.4 1 0 0 1 1 1 1 GINS complex protein UPF0242 PF06785.6 EDK36261.2 - 0.014 14.1 0.6 0.014 14.1 0.4 1.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) AAA_34 PF13872.1 EDK36261.2 - 0.014 14.1 0.3 0.023 13.5 0.2 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 GCIP PF13324.1 EDK36261.2 - 0.24 10.5 2.9 1.1 8.4 2.0 1.9 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting Med11 PF10280.4 EDK36262.2 - 3.1e-30 104.6 0.6 3.5e-30 104.4 0.4 1.0 1 0 0 1 1 1 1 Mediator complex protein Mur_ligase_M PF08245.7 EDK36263.2 - 1.7e-06 28.1 0.2 9.6e-06 25.7 0.1 2.2 1 1 0 1 1 1 1 Mur ligase middle domain WD40 PF00400.27 EDK36264.2 - 2.8e-13 49.1 8.1 0.00043 20.0 0.0 5.2 4 1 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.1 EDK36264.2 - 0.035 14.4 3.0 1.8 8.9 0.0 3.6 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.27 EDK36265.1 - 1.1e-42 142.3 13.6 3.7e-11 42.4 0.1 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 EDK36265.1 - 4.1e-07 28.5 2.3 0.0012 17.1 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 KOW PF00467.24 EDK36265.1 - 0.035 13.8 0.0 1.4 8.7 0.0 2.8 2 1 0 2 2 2 0 KOW motif Ribosomal_L21e PF01157.13 EDK36265.1 - 0.076 12.8 0.0 14 5.5 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein L21e Polysacc_synt_2 PF02719.10 EDK36265.1 - 0.089 11.6 0.0 0.12 11.2 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein UPF0052 PF01933.13 EDK36266.2 - 1.9e-57 194.8 0.0 2.9e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 ABA_GPCR PF12430.3 EDK36266.2 - 0.11 11.6 0.0 0.25 10.4 0.0 1.5 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor IF-2B PF01008.12 EDK36267.2 - 1.9e-68 230.4 0.0 2.7e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sin_N PF04801.8 EDK36268.2 - 1.8e-20 73.2 1.2 8.2e-20 71.0 0.8 1.8 1 1 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.24 EDK36269.2 - 2.3e-42 144.3 0.3 4.8e-42 143.3 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EDK36269.2 - 3.1e-21 74.6 0.1 9.7e-21 73.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EDK36269.2 - 2.3e-17 62.6 0.0 6e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK36269.2 - 1.7e-05 24.7 0.1 0.00013 21.9 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DcpS_C PF11969.3 EDK36270.2 - 4.4e-32 110.7 0.0 8e-32 109.9 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 EDK36270.2 - 5.6e-28 97.5 0.0 9.6e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.18 EDK36270.2 - 0.037 14.5 0.6 0.093 13.2 0.1 1.9 2 0 0 2 2 2 0 HIT domain TMEM37 PF15108.1 EDK36270.2 - 0.073 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF2404 PF10296.4 EDK36271.2 - 1.2e-07 31.7 0.0 0.0001 22.3 0.0 2.5 2 0 0 2 2 2 2 Putative integral membrane protein conserved region (DUF2404) MFS_1 PF07690.11 EDK36272.1 - 5.4e-35 120.7 24.1 7.6e-35 120.2 16.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily ERGIC_N PF13850.1 EDK36272.1 - 0.026 14.4 0.6 11 6.0 0.1 3.3 3 0 0 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) 2TM PF13239.1 EDK36272.1 - 0.11 12.5 1.6 16 5.6 0.0 3.1 2 0 0 2 2 2 0 2TM domain GFO_IDH_MocA PF01408.17 EDK36273.2 - 1.8e-22 80.1 0.3 2.6e-22 79.5 0.2 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EDK36273.2 - 2.7e-14 52.9 0.0 5.2e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.19 EDK36273.2 - 0.00088 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 EDK36273.2 - 0.072 13.1 0.1 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase L51_S25_CI-B8 PF05047.11 EDK36274.2 - 3.5e-10 39.4 0.0 4.4e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain zf-XS PF03470.9 EDK36274.2 - 0.098 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 XS zinc finger domain IF2_N PF04760.10 EDK36274.2 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region LigB PF02900.13 EDK36275.2 - 1.4e-35 122.6 0.0 2e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase YpjP PF14005.1 EDK36275.2 - 0.03 14.1 0.0 5.1 6.8 0.0 2.7 3 0 0 3 3 3 0 YpjP-like protein OmpH PF03938.9 EDK36276.2 - 0.0098 15.8 8.9 0.018 14.9 5.5 1.9 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Effector_1 PF04518.7 EDK36276.2 - 2.8 6.8 9.1 5.4 5.8 6.3 1.4 1 0 0 1 1 1 0 Effector from type III secretion system BTB PF00651.26 EDK36277.2 - 2.9e-20 72.3 0.4 1.5e-09 37.8 0.0 2.8 2 1 0 2 2 2 2 BTB/POZ domain Ank PF00023.25 EDK36277.2 - 1.3e-07 31.0 0.0 3.9e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.1 EDK36277.2 - 1.1e-05 25.4 0.0 2.8e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK36277.2 - 1.4e-05 25.3 0.0 3.9e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK36277.2 - 2.6e-05 24.6 0.0 8.6e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK36277.2 - 0.013 15.7 0.0 0.14 12.4 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat NUC173 PF08161.7 EDK36278.2 - 3.5e-77 258.2 4.7 3.9e-74 248.3 0.1 3.4 4 0 0 4 4 4 2 NUC173 domain Ipi1_N PF12333.3 EDK36278.2 - 0.0018 18.2 1.2 2.2 8.3 0.0 4.2 4 0 0 4 4 4 2 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.17 EDK36278.2 - 0.0049 16.8 0.0 13 6.2 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat Ribosomal_S16 PF00886.14 EDK36279.1 - 1.9e-25 88.3 0.0 2.7e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 Ribosomal_L10 PF00466.15 EDK36282.1 - 3.1e-27 94.3 0.0 6.5e-27 93.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 EDK36282.1 - 1.1e-19 70.5 10.2 1.7e-19 69.9 4.3 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein Metallophos PF00149.23 EDK36283.2 - 1.5e-08 34.3 3.9 1.5e-08 34.3 2.7 1.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Homeobox PF00046.24 EDK36284.2 - 3.5e-15 55.3 3.9 6.2e-15 54.5 2.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EDK36284.2 - 9.1 6.0 7.6 12 5.7 1.9 3.1 2 1 0 2 2 2 0 Homeobox KN domain Ribosomal_S13 PF00416.17 EDK36285.1 - 7.4e-41 138.9 1.8 8.6e-41 138.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 EDK36285.1 - 0.00075 18.1 0.0 0.00077 18.1 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3196 PF11428.3 EDK36285.1 - 0.042 13.1 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3196) Ribosomal_L4 PF00573.17 EDK36286.1 - 8.4e-47 159.0 0.0 1e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Peptidase_S10 PF00450.17 EDK36287.2 - 5.1e-100 335.5 0.0 7.4e-100 335.0 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase E1-E2_ATPase PF00122.15 EDK36287.2 - 0.017 14.1 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 E1-E2 ATPase NmrA PF05368.8 EDK36288.2 - 8.7e-50 169.1 0.1 1.1e-49 168.8 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EDK36288.2 - 5.8e-10 39.4 0.0 7.7e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EDK36288.2 - 4.6e-07 28.8 0.0 7.5e-07 28.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.13 EDK36288.2 - 0.05 13.6 0.0 0.094 12.7 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Sugar_tr PF00083.19 EDK36289.1 - 1e-83 281.4 21.3 1.2e-83 281.2 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK36289.1 - 1.3e-23 83.2 25.9 8.3e-20 70.7 11.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK36289.1 - 0.00028 19.2 2.6 0.00028 19.2 1.8 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cellulase PF00150.13 EDK36290.1 - 4.5e-32 111.3 1.6 8.8e-32 110.4 1.1 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Phosphorylase PF00343.15 EDK36292.2 - 4.1e-298 990.2 1.7 4.8e-298 990.0 1.2 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase WD40 PF00400.27 EDK36294.2 - 1.4e-12 46.9 8.2 0.021 14.7 0.0 6.5 6 1 0 6 6 6 4 WD domain, G-beta repeat PQQ_3 PF13570.1 EDK36294.2 - 0.0068 16.6 1.2 5.2 7.4 0.1 3.8 4 0 0 4 4 4 2 PQQ-like domain PWWP PF00855.12 EDK36295.2 - 5.7e-20 71.3 0.1 5.7e-20 71.3 0.0 3.3 4 1 0 4 4 4 1 PWWP domain MAGE PF01454.14 EDK36295.2 - 0.36 10.1 8.1 0.055 12.8 0.8 2.8 3 0 0 3 3 3 0 MAGE family GAGA_bind PF06217.7 EDK36295.2 - 5.9 6.7 20.3 0.56 10.1 3.3 2.5 3 0 0 3 3 3 0 GAGA binding protein-like family CDC45 PF02724.9 EDK36295.2 - 8 4.3 23.0 0.9 7.4 8.3 2.4 2 0 0 2 2 2 0 CDC45-like protein DUF4446 PF14584.1 EDK36296.2 - 0.041 13.7 0.1 0.091 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) FA_desaturase PF00487.19 EDK36296.2 - 0.078 12.4 3.4 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 Fatty acid desaturase DUF4116 PF13475.1 EDK36296.2 - 0.11 11.9 0.0 0.53 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) Sen15 PF09631.5 EDK36296.2 - 0.16 12.1 0.5 1.2 9.4 0.0 2.5 3 0 0 3 3 3 0 Sen15 protein DUF3278 PF11683.3 EDK36296.2 - 0.19 11.7 6.4 0.25 11.3 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) Ost4 PF10215.4 EDK36296.2 - 0.38 10.2 2.5 1 8.9 0.2 2.7 3 0 0 3 3 3 0 Oligosaccaryltransferase DUF3487 PF11990.3 EDK36296.2 - 0.89 8.9 4.5 5.3 6.4 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) DUF4131 PF13567.1 EDK36296.2 - 4.9 6.5 7.0 10 5.4 1.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SRF-TF PF00319.13 EDK36297.2 - 1.6e-23 81.6 0.2 2.2e-23 81.1 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDC45 PF02724.9 EDK36297.2 - 0.17 9.8 0.1 0.23 9.4 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein PSP1 PF04468.7 EDK36298.2 - 7.2e-32 109.2 0.1 1.3e-31 108.4 0.1 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF3698 PF12479.3 EDK36298.2 - 0.049 13.7 0.2 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) bZIP_2 PF07716.10 EDK36299.1 - 6.1e-11 41.9 10.5 1.3e-10 40.9 7.3 1.5 1 0 0 1 1 1 1 Basic region leucine zipper DUF2205 PF10224.4 EDK36299.1 - 0.0044 16.5 3.2 0.0082 15.7 2.2 1.5 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) TSC22 PF01166.13 EDK36299.1 - 0.0095 15.8 2.2 0.018 14.9 1.5 1.6 1 0 0 1 1 1 1 TSC-22/dip/bun family bZIP_1 PF00170.16 EDK36299.1 - 0.015 15.2 15.9 0.048 13.6 11.0 1.8 1 1 0 1 1 1 0 bZIP transcription factor Herpes_BLRF2 PF05812.7 EDK36299.1 - 0.018 14.8 3.4 0.018 14.8 2.4 2.0 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein AAA_23 PF13476.1 EDK36299.1 - 0.03 14.6 3.4 0.033 14.5 2.3 1.2 1 0 0 1 1 1 0 AAA domain DUF4094 PF13334.1 EDK36299.1 - 0.039 14.3 7.0 0.044 14.1 4.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) FKBP_N PF01346.13 EDK36299.1 - 0.13 12.3 5.5 0.19 11.7 3.8 1.4 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase TBPIP PF07106.8 EDK36299.1 - 0.27 10.7 11.8 0.4 10.2 8.2 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 EDK36299.1 - 0.57 10.5 8.2 0.77 10.1 5.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Ax_dynein_light PF10211.4 EDK36299.1 - 0.78 9.5 11.2 1.1 9.0 7.8 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain GBP_C PF02841.9 EDK36299.1 - 2.2 7.4 13.6 2.7 7.0 9.4 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DivIC PF04977.10 EDK36299.1 - 3.4 7.2 7.1 3.7 7.0 4.3 1.6 1 1 0 1 1 1 0 Septum formation initiator Pkinase PF00069.20 EDK36300.2 - 2.9e-63 213.4 0.0 5.4e-40 137.1 0.1 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36300.2 - 5.9e-29 100.9 0.1 4.7e-22 78.2 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 EDK36300.2 - 1.6e-08 34.5 0.0 3.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 EDK36300.2 - 2.1e-05 23.6 0.1 0.00016 20.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK36300.2 - 0.00055 19.7 0.0 0.0078 15.9 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EDK36300.2 - 0.0062 15.4 0.0 0.014 14.2 0.0 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 EDK36300.2 - 0.0092 15.0 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_9 PF13426.1 EDK36300.2 - 0.024 14.9 0.0 0.079 13.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain PAS PF00989.19 EDK36300.2 - 0.076 12.7 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 PAS fold RNase_T PF00929.19 EDK36301.1 - 2.1e-29 102.8 0.2 3.3e-29 102.2 0.1 1.3 1 0 0 1 1 1 1 Exonuclease DUF2781 PF10914.3 EDK36302.2 - 7.8e-44 149.0 13.3 8.9e-44 148.8 9.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF2217 PF10265.4 EDK36303.2 - 0.027 13.2 4.6 0.029 13.1 3.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Plus-3 PF03126.13 EDK36304.2 - 4.5e-32 110.3 0.1 1.6e-31 108.5 0.1 2.0 1 0 0 1 1 1 1 Plus-3 domain zf-Dof PF02701.10 EDK36304.2 - 0.093 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Dof domain, zinc finger Herpes_capsid PF06112.6 EDK36305.2 - 5.4 7.0 8.6 9.3 6.2 6.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ribosomal_S28e PF01200.13 EDK36306.1 - 7.2e-34 115.3 3.0 8.3e-34 115.1 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Abhydrolase_6 PF12697.2 EDK36307.2 - 4.4e-25 88.8 0.0 6.4e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK36307.2 - 2.2e-18 66.6 0.0 5.4e-18 65.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK36307.2 - 3.9e-10 39.6 0.0 1.9e-09 37.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EDK36307.2 - 0.00015 21.5 0.0 0.00035 20.3 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DUF915 PF06028.6 EDK36307.2 - 0.00089 18.4 0.0 0.0021 17.1 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_3 PF07859.8 EDK36307.2 - 0.00089 18.8 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 EDK36307.2 - 0.011 14.5 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Ser_hydrolase PF06821.8 EDK36307.2 - 0.098 12.2 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase Thioesterase PF00975.15 EDK36307.2 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 2 0 0 2 2 2 0 Thioesterase domain tRNA-synt_1c PF00749.16 EDK36308.2 - 1.4e-107 358.9 0.0 1.2e-106 355.9 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.10 EDK36308.2 - 4.2e-57 192.2 0.2 6.3e-57 191.6 0.1 1.3 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.13 EDK36308.2 - 1.1e-36 126.1 2.3 4.4e-36 124.1 0.2 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.10 EDK36308.2 - 5.8e-22 78.1 5.1 1.7e-21 76.7 3.5 1.8 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 VitK2_biosynth PF02621.9 EDK36308.2 - 0.034 13.3 0.0 0.21 10.7 0.0 1.9 2 0 0 2 2 2 0 Menaquinone biosynthesis CBM_21 PF03370.8 EDK36309.2 - 3.6e-27 94.5 0.9 3.6e-27 94.5 0.6 1.9 2 0 0 2 2 2 1 Putative phosphatase regulatory subunit Thg1C PF14413.1 EDK36310.2 - 1e-52 176.9 1.6 1.4e-52 176.4 1.1 1.2 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.7 EDK36310.2 - 3.8e-45 152.8 1.0 4.4e-45 152.6 0.1 1.5 2 0 0 2 2 2 1 tRNAHis guanylyltransferase RNA_pol_Rpb2_6 PF00562.23 EDK36311.2 - 8.4e-114 380.2 0.0 1.2e-113 379.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EDK36311.2 - 1.7e-42 144.6 0.1 2.4e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EDK36311.2 - 2.4e-30 105.3 0.0 7.2e-30 103.8 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 EDK36311.2 - 1.4e-24 85.5 0.0 3.6e-24 84.2 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 EDK36311.2 - 3.1e-24 84.6 0.0 6.4e-24 83.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.15 EDK36311.2 - 1.4e-15 57.2 0.0 5.1e-15 55.5 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 EDK36311.2 - 9e-05 22.3 0.1 0.00026 20.9 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_POL_M_15KD PF02150.11 EDK36311.2 - 0.022 14.4 0.0 0.063 12.9 0.0 1.8 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit PRK PF00485.13 EDK36312.1 - 1.3e-08 34.6 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 EDK36312.1 - 1.5e-08 35.4 0.1 4.2e-08 34.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EDK36312.1 - 2.5e-06 26.7 0.1 5.1e-06 25.7 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 EDK36312.1 - 3.9e-06 26.9 0.0 4.8e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EDK36312.1 - 4.1e-06 26.7 0.2 4.9e-05 23.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK36312.1 - 2.6e-05 23.8 0.1 5.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain NB-ARC PF00931.17 EDK36312.1 - 6.8e-05 21.8 0.1 9.7e-05 21.3 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.1 EDK36312.1 - 8.4e-05 22.8 0.0 0.00018 21.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 EDK36312.1 - 0.00021 20.9 0.0 0.00037 20.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 EDK36312.1 - 0.0004 20.5 0.0 0.00062 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EDK36312.1 - 0.00058 18.8 0.0 0.0011 17.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.10 EDK36312.1 - 0.0012 18.6 0.1 0.0031 17.2 0.0 1.7 2 0 0 2 2 1 1 NTPase Arch_ATPase PF01637.13 EDK36312.1 - 0.0012 18.5 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase cobW PF02492.14 EDK36312.1 - 0.0013 18.2 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 EDK36312.1 - 0.0014 17.4 0.0 0.0024 16.7 0.0 1.2 1 0 0 1 1 1 1 ArgK protein AAA PF00004.24 EDK36312.1 - 0.0021 18.2 0.0 0.0036 17.4 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 EDK36312.1 - 0.0022 17.0 0.0 0.0029 16.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.8 EDK36312.1 - 0.0034 16.1 0.0 0.0051 15.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus KTI12 PF08433.5 EDK36312.1 - 0.0043 16.2 0.0 0.0082 15.3 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 RuvB_N PF05496.7 EDK36312.1 - 0.0059 15.6 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus MobB PF03205.9 EDK36312.1 - 0.0071 16.0 0.1 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.10 EDK36312.1 - 0.0088 15.8 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit KAP_NTPase PF07693.9 EDK36312.1 - 0.0093 14.9 0.0 0.0093 14.9 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain TrwB_AAD_bind PF10412.4 EDK36312.1 - 0.011 14.3 0.0 0.019 13.5 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_5 PF07728.9 EDK36312.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 EDK36312.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.1 EDK36312.1 - 0.015 15.1 0.0 0.031 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EDK36312.1 - 0.018 14.6 0.1 0.088 12.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Viral_helicase1 PF01443.13 EDK36312.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.4 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Pox_A32 PF04665.7 EDK36312.1 - 0.024 13.9 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein RNA_helicase PF00910.17 EDK36312.1 - 0.025 14.7 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.1 EDK36312.1 - 0.026 14.4 0.0 0.048 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 EDK36312.1 - 0.03 13.9 0.0 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Mg_chelatase PF01078.16 EDK36312.1 - 0.031 13.4 0.0 0.058 12.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.13 EDK36312.1 - 0.033 13.6 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.1 EDK36312.1 - 0.044 13.1 0.0 0.083 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ADK PF00406.17 EDK36312.1 - 0.061 13.2 0.0 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 Adenylate kinase Miro PF08477.8 EDK36312.1 - 0.082 13.4 0.0 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein KaiC PF06745.8 EDK36312.1 - 0.086 11.9 0.1 0.19 10.7 0.1 1.6 1 1 0 1 1 1 0 KaiC DUF258 PF03193.11 EDK36312.1 - 0.1 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 EDK36312.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PIN_4 PF13638.1 EDK36314.2 - 3.6e-32 111.2 0.1 1e-31 109.8 0.1 1.8 1 0 0 1 1 1 1 PIN domain DUF928 PF06051.7 EDK36314.2 - 0.026 14.1 0.4 0.045 13.3 0.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) DUF155 PF02582.9 EDK36315.2 - 6.7e-60 201.9 1.0 1.2e-59 201.1 0.1 1.9 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 tRNA-synt_1c PF00749.16 EDK36316.2 - 2.5e-109 364.7 0.0 3.4e-109 364.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 EDK36316.2 - 1.5e-41 141.9 0.2 3.3e-41 140.8 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain MFS_1 PF07690.11 EDK36317.2 - 4.9e-37 127.4 27.6 4.9e-37 127.4 19.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36317.2 - 2.8e-15 55.8 23.2 7.7e-15 54.4 16.3 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EDK36317.2 - 0.00023 19.5 1.0 0.00042 18.6 0.7 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SBDS PF01172.13 EDK36318.2 - 4e-23 81.0 0.1 4.5e-23 80.8 0.1 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.15 EDK36319.2 - 4e-16 59.3 2.3 6.8e-16 58.6 1.6 1.3 1 0 0 1 1 1 1 RhoGEF domain Tcf25 PF04910.9 EDK36320.2 - 7.2e-90 301.5 0.2 1.1e-89 300.9 0.1 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Fis1_TPR_C PF14853.1 EDK36320.2 - 0.014 15.2 0.1 0.93 9.4 0.0 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.1 EDK36320.2 - 0.26 12.0 2.1 10 6.9 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldedh PF00171.17 EDK36321.2 - 3.6e-124 414.5 0.0 4.3e-124 414.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Prok-E2_B PF14461.1 EDK36321.2 - 0.18 11.5 0.3 0.51 10.0 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic E2 family B V-ATPase_G PF03179.10 EDK36322.1 - 3.5e-23 81.8 12.3 3.7e-23 81.8 8.6 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.13 EDK36322.1 - 0.00028 20.6 10.1 0.00036 20.3 7.0 1.2 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) DUF3552 PF12072.3 EDK36322.1 - 0.0035 16.5 11.0 0.0039 16.4 7.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) TraC_F_IV PF11130.3 EDK36322.1 - 0.025 14.0 0.1 0.026 13.9 0.1 1.1 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer KfrA_N PF11740.3 EDK36322.1 - 0.099 13.0 4.0 0.063 13.7 1.5 1.5 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term RRF PF01765.14 EDK36322.1 - 0.13 11.7 8.7 0.14 11.5 6.0 1.0 1 0 0 1 1 1 0 Ribosome recycling factor RE_AlwI PF09491.5 EDK36322.1 - 0.19 10.1 4.9 0.21 10.0 3.4 1.0 1 0 0 1 1 1 0 AlwI restriction endonuclease CALCOCO1 PF07888.6 EDK36322.1 - 0.21 9.8 7.7 0.23 9.7 5.3 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like EF-1_beta_acid PF10587.4 EDK36322.1 - 0.3 11.2 9.0 0.14 12.3 2.6 2.5 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region DUF3496 PF12001.3 EDK36322.1 - 0.34 11.1 3.7 0.39 10.9 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) Ax_dynein_light PF10211.4 EDK36322.1 - 0.59 9.9 10.1 0.64 9.8 7.0 1.0 1 0 0 1 1 1 0 Axonemal dynein light chain Atg14 PF10186.4 EDK36322.1 - 1.4 7.8 6.1 1.4 7.8 4.2 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Seryl_tRNA_N PF02403.17 EDK36322.1 - 1.7 8.6 10.0 3.7 7.5 6.9 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF883 PF05957.8 EDK36322.1 - 2.4 8.6 7.1 5.6 7.4 4.9 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Arc_PepC_II PF06847.6 EDK36322.1 - 2.6 8.5 4.2 5.5 7.4 2.7 1.7 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II SseC PF04888.7 EDK36322.1 - 3.1 7.0 5.5 3 7.1 3.8 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF4337 PF14235.1 EDK36322.1 - 3.5 7.4 8.5 4.2 7.1 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) APG6 PF04111.7 EDK36322.1 - 3.8 6.4 10.2 3.8 6.4 7.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.1 EDK36322.1 - 4.2 6.2 7.3 4.3 6.2 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Helicase_C PF00271.26 EDK36323.2 - 6.2e-16 58.0 0.0 4.7e-15 55.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OKR_DC_1_N PF03709.10 EDK36323.2 - 0.0023 17.9 0.1 0.076 13.0 0.0 3.1 3 0 0 3 3 3 1 Orn/Lys/Arg decarboxylase, N-terminal domain SNF2_N PF00176.18 EDK36324.2 - 2.5e-71 239.9 0.3 2.5e-71 239.9 0.2 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain HSA PF07529.8 EDK36324.2 - 4.1e-06 26.4 4.9 4.1e-06 26.4 3.4 3.9 3 1 1 4 4 4 1 HSA DEAD PF00270.24 EDK36324.2 - 9.1e-06 25.2 0.0 3.3e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase NDUF_B8 PF05821.6 EDK36325.1 - 1.7e-12 47.3 0.5 2.3e-12 46.9 0.3 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) RRM_1 PF00076.17 EDK36327.2 - 1.1e-34 117.8 0.0 6.4e-13 48.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36327.2 - 1.2e-21 76.4 0.0 2.3e-06 27.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36327.2 - 4.9e-14 51.9 0.2 0.00078 19.2 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK36327.2 - 0.00039 20.1 0.0 0.001 18.8 0.0 1.8 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EDK36327.2 - 0.0016 18.2 0.0 0.0049 16.6 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif G-patch PF01585.18 EDK36328.2 - 1.9e-13 49.9 0.3 3.1e-13 49.2 0.2 1.3 1 0 0 1 1 1 1 G-patch domain DUF4187 PF13821.1 EDK36328.2 - 3.1e-11 42.6 2.4 9.2e-11 41.1 1.7 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch_2 PF12656.2 EDK36328.2 - 0.00087 19.0 0.1 0.00087 19.0 0.1 2.4 2 1 1 3 3 3 1 DExH-box splicing factor binding site Pox_Ag35 PF03286.9 EDK36328.2 - 1.4 8.3 6.6 2.5 7.5 4.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Med4 PF10018.4 EDK36329.2 - 1e-40 139.1 9.9 1.5e-40 138.6 6.8 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 RBFA PF02033.13 EDK36329.2 - 0.019 15.0 0.1 0.046 13.7 0.1 1.7 1 1 0 1 1 1 0 Ribosome-binding factor A Exonuc_VII_L PF02601.10 EDK36329.2 - 0.025 13.7 4.0 0.033 13.3 2.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_2 PF07716.10 EDK36329.2 - 0.96 9.3 9.2 4.3 7.2 0.6 2.6 1 1 1 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.16 EDK36329.2 - 1.1 9.2 8.8 0.57 10.1 0.8 3.0 1 1 2 3 3 3 0 bZIP transcription factor NYD-SP28_assoc PF14775.1 EDK36329.2 - 2.2 8.0 4.9 5.2 6.8 3.2 1.8 1 1 0 1 1 1 0 Sperm tail C-terminal domain DUF972 PF06156.8 EDK36329.2 - 3.1 8.1 13.4 1.6 9.1 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF972) SNAPc19 PF15497.1 EDK36329.2 - 7.6 6.8 15.2 0.065 13.4 1.8 2.8 2 1 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Ferrochelatase PF00762.14 EDK36330.1 - 3.1e-95 318.7 0.0 3.7e-95 318.5 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Glyco_transf_7C PF02709.9 EDK36330.1 - 0.02 14.3 0.0 0.06 12.8 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain of galactosyltransferase MBOAT PF03062.14 EDK36331.2 - 2e-52 178.3 9.3 3.1e-52 177.7 6.4 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Abi PF02517.11 EDK36331.2 - 0.64 10.1 8.6 0.71 10.0 0.8 3.6 2 1 1 3 3 3 0 CAAX protease self-immunity ADH_zinc_N PF00107.21 EDK36332.2 - 1.6e-13 50.3 0.2 2.6e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK36332.2 - 1.6e-05 24.5 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Cnd1 PF12717.2 EDK36333.2 - 1e-50 172.0 12.2 2.7e-49 167.4 0.4 4.5 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 EDK36333.2 - 2.4e-47 160.7 1.3 2.4e-46 157.4 0.1 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.1 EDK36333.2 - 1e-12 48.1 0.0 2e-05 24.7 0.0 4.8 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.17 EDK36333.2 - 5.1e-11 41.6 2.2 0.09 12.9 0.0 6.3 5 0 0 5 5 5 4 HEAT repeat HEAT_EZ PF13513.1 EDK36333.2 - 2.3e-07 31.0 0.1 1.9 9.0 0.0 6.8 7 0 0 7 7 7 1 HEAT-like repeat Cnd3 PF12719.2 EDK36333.2 - 0.00043 19.3 7.3 0.0072 15.3 1.0 4.5 3 3 1 4 4 4 1 Nuclear condensing complex subunits, C-term domain DUF2435 PF10363.4 EDK36333.2 - 0.012 15.4 0.1 0.71 9.8 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2435) TAF4 PF05236.9 EDK36334.2 - 5.4e-76 255.3 8.3 5.4e-76 255.3 5.8 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family RTC PF01137.16 EDK36335.2 - 3.1e-56 189.6 0.0 3.7e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 EDK36335.2 - 1.9e-31 108.1 0.1 3.1e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain FAT PF02259.18 EDK36336.2 - 5.7e-139 463.0 0.2 5.7e-139 463.0 0.1 2.4 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.22 EDK36336.2 - 9.7e-57 192.1 0.1 1.8e-56 191.2 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 EDK36336.2 - 2.1e-42 143.2 4.8 5.2e-41 138.7 0.3 3.6 3 0 0 3 3 3 1 Rapamycin binding domain DUF3385 PF11865.3 EDK36336.2 - 1.1e-32 113.2 2.3 6.6e-32 110.6 0.1 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3385) FATC PF02260.15 EDK36336.2 - 6.1e-18 63.9 0.1 1.5e-17 62.6 0.1 1.7 1 0 0 1 1 1 1 FATC domain TPR_16 PF13432.1 EDK36336.2 - 0.00028 21.4 2.0 0.98 10.1 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36336.2 - 0.0039 17.4 1.4 24 5.3 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 EDK36336.2 - 0.088 12.9 1.0 19 5.5 0.0 3.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EDK36336.2 - 3.9 8.3 6.0 51 4.9 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Dopey_N PF04118.9 EDK36336.2 - 4.3 6.0 13.1 2.5 6.7 1.4 3.5 2 1 1 4 4 4 0 Dopey, N-terminal Actin PF00022.14 EDK36337.1 - 1e-91 307.2 0.0 2.3e-91 306.1 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EDK36337.1 - 0.00044 18.9 0.0 0.12 10.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Cpn60_TCP1 PF00118.19 EDK36338.1 - 1.1e-145 486.0 2.3 1.2e-145 485.8 1.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Hydrolase_like2 PF13246.1 EDK36338.1 - 0.042 13.8 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Resolvase PF00239.16 EDK36338.1 - 0.097 12.5 0.3 2.2 8.1 0.1 2.4 2 0 0 2 2 2 0 Resolvase, N terminal domain HEAT_2 PF13646.1 EDK36339.2 - 3e-37 126.7 0.1 1.8e-15 56.9 0.0 3.8 2 2 3 5 5 5 4 HEAT repeats HEAT_PBS PF03130.11 EDK36339.2 - 3.9e-20 70.2 0.9 1.5e-05 24.9 0.0 7.0 9 1 0 9 9 9 4 PBS lyase HEAT-like repeat HEAT PF02985.17 EDK36339.2 - 1.2e-14 52.9 0.7 0.051 13.6 0.1 6.7 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 EDK36339.2 - 1.3e-13 50.9 1.0 0.042 14.3 0.0 5.8 6 1 0 6 6 6 3 HEAT-like repeat Arm PF00514.18 EDK36339.2 - 0.013 15.3 0.1 0.55 10.1 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.2 EDK36339.2 - 0.07 12.9 0.5 39 4.0 0.0 4.2 2 2 4 6 6 6 0 non-SMC mitotic condensation complex subunit 1 TFIIS_C PF01096.13 EDK36340.1 - 5.2e-18 64.3 1.5 5.2e-18 64.3 1.0 3.2 4 0 0 4 4 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 EDK36340.1 - 2.7e-09 36.5 7.0 3.9e-07 29.6 0.1 3.2 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit DZR PF12773.2 EDK36340.1 - 0.0015 18.3 7.8 0.09 12.6 0.2 2.9 2 1 0 2 2 2 1 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 EDK36340.1 - 0.0043 16.8 4.7 0.02 14.6 0.6 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain Lar_restr_allev PF14354.1 EDK36340.1 - 0.0046 17.2 0.5 0.0046 17.2 0.4 2.7 2 1 0 2 2 2 1 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.1 EDK36340.1 - 0.023 14.2 17.1 0.24 10.9 0.8 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Terminase_GpA PF05876.7 EDK36340.1 - 0.023 13.0 0.4 0.034 12.5 0.2 1.3 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) zf-C4_Topoisom PF01396.14 EDK36340.1 - 0.031 13.7 5.9 0.092 12.2 2.0 2.9 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger C1_1 PF00130.17 EDK36340.1 - 0.042 13.5 3.2 0.41 10.4 0.1 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) IBR PF01485.16 EDK36340.1 - 0.043 13.7 7.3 1.2 9.0 0.2 2.6 2 1 0 2 2 2 0 IBR domain zf-C3HC4_3 PF13920.1 EDK36340.1 - 0.063 12.9 2.8 3.8 7.2 0.2 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIB PF13453.1 EDK36340.1 - 0.063 12.4 0.8 0.063 12.4 0.5 2.3 2 1 0 2 2 2 0 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.7 EDK36340.1 - 0.067 12.5 13.9 0.077 12.3 2.4 3.1 2 2 1 3 3 3 0 TFIIB zinc-binding Mu-like_Com PF10122.4 EDK36340.1 - 0.068 12.2 1.5 3.5 6.7 0.3 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com DUF2387 PF09526.5 EDK36340.1 - 0.069 13.0 3.2 0.11 12.3 0.0 2.5 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Nop10p PF04135.7 EDK36340.1 - 0.075 12.7 0.3 0.21 11.3 0.2 1.9 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family zf-PHD-like PF15446.1 EDK36340.1 - 0.087 12.1 3.9 0.033 13.4 0.9 1.6 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain DUF2072 PF09845.4 EDK36340.1 - 0.096 12.6 0.1 0.096 12.6 0.1 2.8 1 1 2 3 3 3 0 Zn-ribbon containing protein (DUF2072) zf-ribbon_3 PF13248.1 EDK36340.1 - 0.12 11.6 13.3 1.3 8.3 0.2 3.6 3 1 1 4 4 4 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EDK36340.1 - 0.15 11.7 9.6 6.2 6.6 0.1 4.1 4 0 0 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 EDK36340.1 - 0.16 11.9 12.9 1.5 8.7 0.1 3.4 3 1 0 3 3 3 0 Zinc ribbon domain Baculo_LEF5_C PF11792.3 EDK36340.1 - 0.17 11.3 0.0 0.17 11.3 0.0 3.0 4 0 0 4 4 3 0 Baculoviridae late expression factor 5 C-terminal domain OrfB_Zn_ribbon PF07282.6 EDK36340.1 - 0.22 11.1 6.8 3.7 7.2 0.1 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_5 PF13719.1 EDK36340.1 - 0.22 11.1 9.5 6.7 6.3 0.1 4.0 4 0 0 4 4 4 0 zinc-ribbon domain RecR PF02132.10 EDK36340.1 - 0.27 10.7 6.3 0.39 10.2 0.9 2.6 2 1 0 2 2 2 0 RecR protein NOB1_Zn_bind PF08772.6 EDK36340.1 - 0.41 10.4 8.2 3.3 7.5 1.2 3.1 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Stc1 PF12898.2 EDK36340.1 - 0.5 10.4 5.0 0.44 10.6 0.2 2.2 1 1 0 2 2 2 0 Stc1 domain Elf1 PF05129.8 EDK36340.1 - 0.53 10.0 7.4 1.3 8.7 0.3 2.6 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zinc-ribbons_6 PF07191.7 EDK36340.1 - 0.55 10.0 5.7 4.2 7.2 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbons zf-DNA_Pol PF08996.5 EDK36340.1 - 0.79 9.0 5.7 0.43 9.8 0.4 2.2 1 1 1 3 3 3 0 DNA Polymerase alpha zinc finger HypA PF01155.14 EDK36340.1 - 1.2 8.8 9.0 11 5.7 3.5 3.0 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Prok-RING_1 PF14446.1 EDK36340.1 - 1.4 8.7 9.1 15 5.4 1.1 3.3 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 zf-C2H2_3 PF13878.1 EDK36340.1 - 1.8 8.1 0.0 1.8 8.1 0.0 3.8 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO zf-C3HC4_4 PF15227.1 EDK36340.1 - 2.4 8.0 5.3 2 8.3 0.6 2.7 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-CHY PF05495.7 EDK36340.1 - 2.5 8.3 8.0 3.1 8.0 0.3 2.7 2 1 0 2 2 2 0 CHY zinc finger Rubredoxin PF00301.15 EDK36340.1 - 2.6 7.9 10.7 21 5.0 0.2 3.9 3 1 1 4 4 4 0 Rubredoxin Ogr_Delta PF04606.7 EDK36340.1 - 3.5 7.3 11.1 0.06 13.0 1.4 2.6 2 1 1 3 3 2 0 Ogr/Delta-like zinc finger DNA_RNApol_7kD PF03604.8 EDK36340.1 - 5.2 6.6 14.1 4.8 6.7 1.3 3.4 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Nudix_N_2 PF14803.1 EDK36340.1 - 5.8 6.6 10.8 9.8 5.9 0.0 3.6 4 0 0 4 4 3 0 Nudix N-terminal zf-AN1 PF01428.11 EDK36340.1 - 6.4 6.7 9.4 62 3.5 1.2 3.5 3 1 1 4 4 4 0 AN1-like Zinc finger RRN7 PF11781.3 EDK36340.1 - 6.7 6.2 9.7 8.2 6.0 0.0 3.9 4 0 0 4 4 4 0 RNA polymerase I-specific transcription initiation factor Rrn7 Rpr2 PF04032.11 EDK36340.1 - 8 6.4 7.8 1.8e+02 2.0 5.4 2.6 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_Tnp_IS91 PF14319.1 EDK36340.1 - 8.7 5.8 7.6 6.9 6.2 0.2 2.6 1 1 3 4 4 4 0 Transposase zinc-binding domain Na_H_Exchanger PF00999.16 EDK36341.2 - 7e-70 235.4 31.6 9.6e-70 235.0 21.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Flavin_Reduct PF01613.13 EDK36342.2 - 8.2e-19 67.9 0.1 1.1e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DHquinase_II PF01220.14 EDK36343.2 - 2e-56 189.2 0.0 2.2e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Dehydroquinase class II PAC2 PF09754.4 EDK36344.2 - 8.9e-38 130.3 0.0 6.1e-37 127.6 0.0 1.9 1 1 0 1 1 1 1 PAC2 family AFT PF08731.6 EDK36345.2 - 9.9e-28 96.5 6.7 1.8e-15 57.0 0.8 2.5 1 1 1 2 2 2 2 Transcription factor AFT DBD_Tnp_Mut PF03108.10 EDK36345.2 - 7.3e-06 25.4 0.4 1.4e-05 24.6 0.3 1.4 1 0 0 1 1 1 1 MuDR family transposase Ribosomal_L12 PF00542.14 EDK36346.1 - 9.1e-20 70.4 6.5 9.1e-20 70.4 4.5 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain TFIIS_C PF01096.13 EDK36347.1 - 4.7e-16 58.1 15.2 2.8e-15 55.6 3.9 3.0 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 EDK36347.1 - 4.2e-13 48.7 5.3 4.2e-13 48.7 3.7 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit DZR PF12773.2 EDK36347.1 - 0.01 15.6 0.5 0.01 15.6 0.4 2.6 2 1 0 2 2 2 0 Double zinc ribbon C1_4 PF07975.7 EDK36347.1 - 0.012 15.5 14.1 0.13 12.2 0.9 3.2 2 2 1 3 3 3 0 TFIIH C1-like domain Lar_restr_allev PF14354.1 EDK36347.1 - 0.015 15.5 5.6 0.24 11.7 0.9 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar Elf1 PF05129.8 EDK36347.1 - 0.045 13.4 5.1 0.85 9.3 0.8 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DUF2387 PF09526.5 EDK36347.1 - 0.1 12.5 6.2 3.8 7.4 0.1 2.3 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) IBR PF01485.16 EDK36347.1 - 0.1 12.4 8.1 0.89 9.4 1.0 2.4 2 0 0 2 2 2 0 IBR domain Zn_ribbon_recom PF13408.1 EDK36347.1 - 0.12 12.6 0.5 0.12 12.6 0.3 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DUF3268 PF11672.3 EDK36347.1 - 0.17 11.9 5.9 1.5 8.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3268) Zn_Tnp_IS1595 PF12760.2 EDK36347.1 - 0.92 9.3 12.7 5.8 6.8 3.3 2.8 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Ribosomal_L44 PF00935.14 EDK36347.1 - 2.6 8.1 5.4 10 6.2 0.0 2.6 2 2 0 2 2 2 0 Ribosomal protein L44 PHD PF00628.24 EDK36347.1 - 3.9 7.2 12.8 1.7 8.3 1.8 2.6 2 1 0 2 2 2 0 PHD-finger zf-C4_Topoisom PF01396.14 EDK36347.1 - 4.6 6.8 12.4 0.19 11.2 0.6 2.5 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-GRF PF06839.7 EDK36347.1 - 7.4 6.5 13.2 1.2 9.1 1.2 2.9 3 0 0 3 3 3 0 GRF zinc finger C1_3 PF07649.7 EDK36347.1 - 8.1 6.5 15.7 1.2 9.2 0.1 3.5 4 1 0 4 4 4 0 C1-like domain Fer4_10 PF13237.1 EDK36347.1 - 8.4 6.2 8.1 9.8 6.0 0.5 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Zn-ribbon_8 PF09723.5 EDK36347.1 - 8.6 6.4 12.8 23 5.0 0.2 4.0 4 0 0 4 4 4 0 Zinc ribbon domain Mut7-C PF01927.11 EDK36347.1 - 8.6 6.3 8.5 21 5.0 2.8 2.4 1 1 1 2 2 2 0 Mut7-C RNAse domain Pkinase PF00069.20 EDK36348.2 - 1.1e-70 237.7 0.0 1.9e-70 237.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36348.2 - 6.2e-40 136.9 0.0 1.2e-39 135.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36348.2 - 1e-05 24.6 0.0 2.4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK36348.2 - 0.024 14.3 1.8 0.42 10.2 0.0 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EDK36348.2 - 0.052 12.8 1.0 0.096 12.0 0.1 2.0 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.6 EDK36348.2 - 0.12 11.1 0.0 0.22 10.2 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Nramp PF01566.13 EDK36349.2 - 1.3e-83 280.8 16.6 4.9e-83 278.8 11.5 1.8 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein DUF3899 PF13038.1 EDK36349.2 - 0.24 11.5 0.1 0.24 11.5 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) HAD PF12710.2 EDK36350.1 - 2.8e-16 60.2 0.0 3.7e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EDK36350.1 - 0.00013 22.1 0.0 0.00053 20.2 0.0 2.0 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 EDK36350.1 - 0.0018 17.6 0.0 0.0083 15.4 0.0 1.8 2 0 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.7 EDK36350.1 - 0.0042 16.2 0.0 0.058 12.5 0.0 2.1 1 1 0 1 1 1 1 Putative Phosphatase P3A PF08727.6 EDK36350.1 - 0.069 12.4 0.0 8.8 5.7 0.0 2.8 3 0 0 3 3 3 0 Poliovirus 3A protein like SpoU_sub_bind PF08032.7 EDK36350.1 - 0.079 13.1 0.0 0.57 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Hydrolase PF00702.21 EDK36350.1 - 0.14 12.5 0.1 0.6 10.4 0.0 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.20 EDK36351.2 - 4.3e-69 232.5 0.0 8.6e-69 231.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36351.2 - 5.1e-32 110.9 0.0 1.5e-31 109.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36351.2 - 0.00036 19.5 0.2 0.14 11.0 0.0 2.8 2 1 0 2 2 2 2 Kinase-like SNF2_N PF00176.18 EDK36352.2 - 2.7e-35 121.6 0.0 3.4e-34 118.0 0.0 2.3 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.10 EDK36352.2 - 0.053 13.3 0.0 0.21 11.4 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.1 EDK36353.2 - 5.1e-09 35.6 6.8 1.1e-08 34.6 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK36353.2 - 1.9e-08 33.8 9.7 4.2e-08 32.7 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK36353.2 - 4.3e-08 32.8 9.0 1e-07 31.6 6.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK36353.2 - 1.2e-07 31.5 10.4 3.7e-07 30.0 7.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK36353.2 - 9.1e-06 25.6 6.5 3e-05 24.0 4.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK36353.2 - 1e-05 25.1 7.8 2.4e-05 23.9 5.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.1 EDK36353.2 - 0.0015 18.0 2.7 0.0035 16.8 1.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Helicase_C PF00271.26 EDK36353.2 - 0.0034 17.2 0.0 0.0095 15.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_4 PF14570.1 EDK36353.2 - 0.0059 16.1 2.9 0.019 14.5 2.0 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Ykof PF07615.6 EDK36353.2 - 0.047 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 YKOF-related Family zf-Apc11 PF12861.2 EDK36353.2 - 0.082 12.7 1.2 0.19 11.5 0.9 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.9 EDK36353.2 - 0.092 12.2 6.3 0.22 11.0 4.4 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_UBOX PF13445.1 EDK36353.2 - 0.23 11.1 7.4 0.68 9.7 5.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK36353.2 - 0.39 10.6 8.9 1.1 9.1 6.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RPA_C PF08784.6 EDK36354.2 - 4.2e-12 46.3 2.6 3.1e-11 43.6 0.1 2.6 2 1 1 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 EDK36354.2 - 7.6e-06 25.6 0.0 1.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PCI PF01399.22 EDK36354.2 - 0.016 15.5 0.2 0.034 14.4 0.0 1.8 2 1 0 2 2 2 0 PCI domain Rrf2 PF02082.15 EDK36354.2 - 0.063 13.4 1.5 7.2 6.8 0.0 2.6 3 0 0 3 3 3 0 Transcriptional regulator SWIB PF02201.13 EDK36356.2 - 2.1e-07 30.5 0.1 0.0077 15.8 0.0 2.5 2 0 0 2 2 2 2 SWIB/MDM2 domain Cyt-b5 PF00173.23 EDK36357.2 - 2.5e-12 46.4 0.0 6.6e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 EDK36357.2 - 7.5e-10 38.6 12.8 2.6e-09 36.8 6.5 2.6 1 1 1 2 2 2 1 Fatty acid desaturase DUF4519 PF15012.1 EDK36357.2 - 3.7 7.5 7.3 32 4.5 1.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) CBS PF00571.23 EDK36358.1 - 2.7e-10 39.8 0.0 1.2e-06 28.1 0.0 2.3 2 0 0 2 2 2 2 CBS domain RRM_1 PF00076.17 EDK36359.2 - 3.3e-31 106.7 0.0 2.1e-15 56.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36359.2 - 3.3e-16 59.0 0.0 7.4e-07 29.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36359.2 - 1.3e-14 53.7 0.0 5.7e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L9_N PF01281.14 EDK36360.2 - 1.3e-11 43.5 0.0 2.6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Big_3 PF07523.7 EDK36360.2 - 0.056 13.5 0.5 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) HCV_capsid PF01543.12 EDK36360.2 - 0.066 13.1 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus capsid protein zf-HIT PF04438.11 EDK36361.2 - 3e-11 42.7 8.7 4.9e-11 42.0 6.1 1.4 1 0 0 1 1 1 1 HIT zinc finger CDC45 PF02724.9 EDK36361.2 - 2.7 5.9 10.8 3.8 5.4 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-B_box PF00643.19 EDK36361.2 - 5.5 6.9 8.6 9.6 6.1 6.0 1.4 1 0 0 1 1 1 0 B-box zinc finger BUD22 PF09073.5 EDK36361.2 - 7.4 5.5 13.7 14 4.6 9.5 1.3 1 0 0 1 1 1 0 BUD22 zf-C3HC4_2 PF13923.1 EDK36361.2 - 9.1 6.4 10.4 17 5.5 7.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Stk19 PF10494.4 EDK36362.2 - 1.2e-87 293.4 0.4 2.2e-87 292.5 0.1 1.6 2 0 0 2 2 2 1 Serine-threonine protein kinase 19 DUF1682 PF07946.9 EDK36363.2 - 4.4e-91 305.0 8.9 5e-91 304.8 6.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Surf_Ag_VNR PF07244.10 EDK36363.2 - 0.18 12.2 2.5 5.8 7.4 0.0 2.7 2 0 0 2 2 2 0 Surface antigen variable number repeat Ank_4 PF13637.1 EDK36364.2 - 9.4e-18 64.2 1.9 7.1e-09 35.9 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EDK36364.2 - 1.4e-15 56.9 0.2 6e-13 48.5 0.1 2.9 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK36364.2 - 6.8e-13 48.7 0.1 1.3e-12 47.8 0.1 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 EDK36364.2 - 3.6e-09 35.9 5.8 1.1e-08 34.4 0.2 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 EDK36364.2 - 1.7e-06 27.6 3.0 4.4e-05 23.3 0.1 3.5 4 0 0 4 4 4 1 Ankyrin repeat TrpBP PF02081.10 EDK36364.2 - 0.085 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein Peptidase_M76 PF09768.4 EDK36365.2 - 8.8e-74 246.6 1.5 1.1e-73 246.3 1.0 1.1 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M91 PF14891.1 EDK36365.2 - 0.11 12.5 0.1 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Effector protein SprT-like PF10263.4 EDK36365.2 - 0.31 10.6 3.2 0.27 10.8 0.6 1.6 1 1 1 2 2 2 0 SprT-like family MBOAT PF03062.14 EDK36366.2 - 1.1e-42 146.3 37.7 1e-39 136.5 26.1 2.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 EDK36366.2 - 0.016 15.2 3.8 0.053 13.6 2.6 1.9 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family NDUFB10 PF10249.4 EDK36366.2 - 0.068 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 AIF_C PF14721.1 EDK36366.2 - 2.1 8.6 6.1 3.1 8.0 0.0 2.9 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term WBS_methylT PF12589.3 EDK36367.1 - 1e-15 57.9 10.1 1.9e-15 57.1 7.0 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 EDK36367.1 - 7.4e-13 48.8 0.0 1.5e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36367.1 - 3.6e-08 33.7 0.1 1.3e-07 31.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK36367.1 - 9.5e-08 31.9 0.0 1.4e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36367.1 - 2.5e-07 30.3 0.0 5.3e-07 29.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK36367.1 - 7.1e-07 29.5 0.0 1.8e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36367.1 - 6.8e-06 26.6 0.0 1.5e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.8 EDK36367.1 - 0.0002 21.4 0.0 0.00055 20.0 0.0 1.8 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_26 PF13659.1 EDK36367.1 - 0.00038 20.4 0.0 0.00079 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 EDK36367.1 - 0.0067 15.9 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 1 DNA methylase PCMT PF01135.14 EDK36367.1 - 0.008 15.7 0.0 0.05 13.1 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.8 EDK36367.1 - 0.016 14.3 0.0 0.037 13.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 EDK36367.1 - 0.017 14.2 0.0 0.098 11.7 0.0 2.0 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 EDK36367.1 - 0.091 12.1 0.8 0.95 8.8 0.1 2.5 2 1 1 3 3 3 0 Methyltransferase small domain Methyltransf_32 PF13679.1 EDK36367.1 - 0.15 11.7 0.2 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain DUF727 PF05303.7 EDK36368.2 - 1.9e-08 34.0 0.2 5.1e-07 29.4 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF727) LSM PF01423.17 EDK36369.1 - 2.4e-08 33.3 0.1 3.2e-08 32.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain EFP PF01132.15 EDK36369.1 - 0.043 13.4 0.1 0.093 12.4 0.0 1.6 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain SM-ATX PF14438.1 EDK36369.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain ABC_tran PF00005.22 EDK36372.1 - 3e-46 157.1 0.1 2.6e-23 82.8 0.0 4.5 3 2 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 EDK36372.1 - 4.9e-17 62.8 0.2 4e-07 30.3 0.0 4.6 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 EDK36372.1 - 1.1e-14 54.2 0.3 5.6e-05 22.4 0.0 4.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK36372.1 - 1e-09 37.7 0.0 0.0015 17.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EDK36372.1 - 1.5e-09 37.2 0.1 0.00011 21.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 EDK36372.1 - 2.4e-09 37.8 7.5 0.0016 18.7 0.0 3.9 4 1 0 4 4 3 2 AAA domain AAA_17 PF13207.1 EDK36372.1 - 3.2e-08 34.4 0.2 0.0052 17.5 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 EDK36372.1 - 8.5e-08 32.3 0.1 0.0011 18.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EDK36372.1 - 9.7e-08 32.2 0.0 0.003 17.7 0.0 3.7 3 1 0 3 3 2 2 AAA domain AAA_10 PF12846.2 EDK36372.1 - 1.8e-07 30.9 0.1 0.19 11.1 0.0 3.8 4 0 0 4 4 4 2 AAA-like domain MMR_HSR1 PF01926.18 EDK36372.1 - 5e-07 29.6 0.0 0.0066 16.3 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase SbcCD_C PF13558.1 EDK36372.1 - 1e-06 28.5 0.0 0.01 15.7 0.0 3.6 3 1 0 3 3 3 2 Putative exonuclease SbcCD, C subunit Miro PF08477.8 EDK36372.1 - 4.4e-06 27.1 0.0 0.095 13.2 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein RNA_helicase PF00910.17 EDK36372.1 - 6.8e-06 26.2 0.0 0.13 12.4 0.0 3.1 2 1 0 2 2 2 2 RNA helicase AAA_18 PF13238.1 EDK36372.1 - 7.5e-06 26.2 0.8 0.027 14.7 0.0 3.6 4 0 0 4 4 2 1 AAA domain AAA_33 PF13671.1 EDK36372.1 - 8.9e-06 25.6 0.0 0.2 11.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain ArgK PF03308.11 EDK36372.1 - 9e-06 24.6 0.1 0.049 12.3 0.0 2.5 2 0 0 2 2 2 2 ArgK protein Dynamin_N PF00350.18 EDK36372.1 - 1.5e-05 24.9 0.0 0.0018 18.0 0.0 3.2 2 0 0 2 2 2 1 Dynamin family MobB PF03205.9 EDK36372.1 - 4.1e-05 23.3 0.0 0.31 10.7 0.0 3.3 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EDK36372.1 - 4.4e-05 23.5 0.1 0.15 12.0 0.0 3.9 4 0 0 4 4 4 1 AAA ATPase domain AAA PF00004.24 EDK36372.1 - 5.3e-05 23.4 0.2 0.49 10.6 0.0 4.3 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) HEAT_2 PF13646.1 EDK36372.1 - 6.1e-05 23.2 2.6 0.012 15.8 0.0 3.7 1 1 2 3 3 3 2 HEAT repeats Arch_ATPase PF01637.13 EDK36372.1 - 0.00011 21.9 0.0 0.36 10.4 0.0 3.4 3 0 0 3 3 2 1 Archaeal ATPase Cnd1 PF12717.2 EDK36372.1 - 0.00021 21.1 0.0 0.0012 18.6 0.0 2.3 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 MutS_V PF00488.16 EDK36372.1 - 0.00025 20.5 0.1 0.15 11.4 0.0 2.4 2 0 0 2 2 2 1 MutS domain V AAA_14 PF13173.1 EDK36372.1 - 0.00037 20.3 0.0 1.9 8.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain Adaptin_N PF01602.15 EDK36372.1 - 0.00077 17.9 7.2 16 3.6 0.1 2.6 1 1 0 1 1 1 0 Adaptin N terminal region cobW PF02492.14 EDK36372.1 - 0.0012 18.3 0.1 0.87 9.0 0.0 3.2 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 EDK36372.1 - 0.0014 18.1 0.0 0.19 11.2 0.0 2.9 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 EDK36372.1 - 0.0017 18.0 0.0 0.82 9.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.1 EDK36372.1 - 0.002 17.7 0.0 3 7.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain HEAT PF02985.17 EDK36372.1 - 0.0034 17.3 2.0 18 5.7 0.0 4.3 5 0 0 5 5 3 0 HEAT repeat Zeta_toxin PF06414.7 EDK36372.1 - 0.004 16.2 0.1 3.2 6.8 0.0 3.4 3 1 0 3 3 3 1 Zeta toxin Septin PF00735.13 EDK36372.1 - 0.024 13.6 1.1 2 7.3 0.0 3.1 3 0 0 3 3 3 0 Septin GTP_EFTU PF00009.22 EDK36372.1 - 0.025 14.0 0.0 10 5.5 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Mg_chelatase PF01078.16 EDK36372.1 - 0.026 13.6 0.0 1 8.4 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF87 PF01935.12 EDK36372.1 - 0.034 13.9 10.5 0.36 10.6 0.0 4.6 6 0 0 6 6 3 0 Domain of unknown function DUF87 AAA_19 PF13245.1 EDK36372.1 - 0.035 13.8 0.0 6.1 6.6 0.0 3.1 3 0 0 3 3 2 0 Part of AAA domain UME PF08064.8 EDK36372.1 - 0.046 13.6 0.2 0.16 11.9 0.1 2.0 1 1 0 1 1 1 0 UME (NUC010) domain FtsK_SpoIIIE PF01580.13 EDK36372.1 - 0.051 13.0 0.3 3.2 7.1 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 EDK36372.1 - 0.059 12.7 0.0 7.6 5.9 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein ParcG PF10274.4 EDK36372.1 - 0.059 13.2 0.5 10 6.0 0.1 2.9 2 1 1 3 3 3 0 Parkin co-regulated protein ATP_bind_1 PF03029.12 EDK36372.1 - 0.072 12.6 0.4 8.1 5.9 0.0 2.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF3349 PF11829.3 EDK36372.1 - 0.95 9.9 3.6 0.69 10.3 0.1 2.6 3 0 0 3 3 1 0 Protein of unknown function (DUF3349) AAA_13 PF13166.1 EDK36372.1 - 1.3 7.3 17.0 1.7 6.9 0.0 4.7 5 0 0 5 5 5 0 AAA domain HEAT_EZ PF13513.1 EDK36372.1 - 3.8 8.1 6.2 92 3.7 0.0 4.4 3 1 2 5 5 4 0 HEAT-like repeat Ammonium_transp PF00909.16 EDK36373.2 - 3.7e-76 256.1 21.7 4.5e-76 255.9 15.0 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family DUF2830 PF11125.3 EDK36373.2 - 1.3 8.8 6.2 3 7.6 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2830) Mito_carr PF00153.22 EDK36374.1 - 5.7e-68 224.6 1.3 4.1e-22 77.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DPM3 PF08285.6 EDK36374.1 - 0.093 12.5 0.1 0.64 9.9 0.0 2.0 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) SOG2 PF10428.4 EDK36375.2 - 3.4e-60 203.9 16.9 1e-34 120.0 1.7 4.1 2 1 2 4 4 4 2 RAM signalling pathway protein LRR_4 PF12799.2 EDK36375.2 - 9.7e-14 50.6 17.0 8.6e-06 25.2 0.4 3.9 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK36375.2 - 8.1e-11 41.5 12.6 7.1e-08 32.0 2.0 3.1 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 EDK36375.2 - 3.4e-10 38.5 10.8 0.25 11.5 0.1 5.1 4 0 0 4 4 4 4 Leucine Rich Repeat LRR_7 PF13504.1 EDK36375.2 - 0.00044 20.0 11.6 8.9 7.0 0.3 5.2 4 0 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.1 EDK36375.2 - 2.7 8.3 11.0 7.5 6.9 0.2 4.4 4 0 0 4 4 4 0 Leucine Rich repeat HMA PF00403.21 EDK36376.2 - 3.8e-10 39.7 0.0 8e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.15 EDK36376.2 - 0.0027 17.8 0.0 0.012 15.8 0.0 2.0 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) RusA PF05866.6 EDK36376.2 - 0.16 12.3 0.1 0.52 10.7 0.0 1.8 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA DUF3419 PF11899.3 EDK36377.2 - 5.1e-151 502.7 0.2 8.1e-151 502.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Ubie_methyltran PF01209.13 EDK36377.2 - 4.9e-10 38.9 0.0 1e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EDK36377.2 - 1.1e-09 38.1 0.0 4.9e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36377.2 - 1.5e-09 38.1 0.1 1.3e-08 35.1 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36377.2 - 4.5e-09 36.6 0.0 1.6e-08 34.9 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK36377.2 - 9.2e-09 35.2 0.0 1.2e-07 31.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36377.2 - 4.1e-06 26.8 0.1 6.5e-05 22.9 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36377.2 - 4.4e-06 27.2 0.0 1.8e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_28 PF02636.12 EDK36377.2 - 0.022 14.1 0.0 0.052 12.9 0.0 1.7 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.15 EDK36377.2 - 0.032 13.2 0.0 0.062 12.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.14 EDK36377.2 - 0.13 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CM_2 PF01817.16 EDK36378.1 - 1.3e-11 44.3 0.1 1.8e-07 31.1 0.0 3.7 2 1 1 3 3 3 2 Chorismate mutase type II DnaJ PF00226.26 EDK36379.2 - 4e-10 39.2 0.9 1.3e-09 37.6 0.6 2.0 1 0 0 1 1 1 1 DnaJ domain Amidohydro_4 PF13147.1 EDK36380.2 - 3.6e-08 33.7 0.0 1.2e-07 32.0 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EDK36380.2 - 8.1e-08 32.2 0.0 1.1e-05 25.3 0.0 2.2 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.6 EDK36380.2 - 1.9e-06 27.3 0.0 3.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EDK36380.2 - 0.0013 18.5 0.0 0.0033 17.2 0.0 1.6 1 0 0 1 1 1 1 Amidohydrolase DUF4124 PF13511.1 EDK36380.2 - 0.025 14.6 0.0 0.08 13.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) Glucosamine_iso PF01182.15 EDK36381.2 - 1.3e-17 64.2 0.0 1.9e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Hexokinase_1 PF00349.16 EDK36382.2 - 2.8e-22 79.0 0.1 6.5e-22 77.8 0.0 1.6 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.11 EDK36382.2 - 5e-22 78.2 0.0 4.4e-21 75.2 0.0 2.1 1 1 0 1 1 1 1 Hexokinase RHD3 PF05879.7 EDK36383.2 - 1e-257 856.8 13.9 1.2e-257 856.6 9.7 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 EDK36383.2 - 9.1e-09 34.7 1.2 1.9e-08 33.6 0.1 2.1 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.18 EDK36383.2 - 2.4e-06 27.4 0.6 7.2e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EDK36383.2 - 0.00015 21.5 0.1 0.00054 19.8 0.1 2.0 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.1 EDK36383.2 - 0.0018 18.2 0.0 0.0047 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 EDK36383.2 - 0.0075 16.7 0.0 0.022 15.2 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 EDK36384.2 - 1.6e-60 203.7 0.0 4.3e-60 202.3 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 EDK36384.2 - 1.1e-22 79.6 0.0 2.4e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EDK36384.2 - 1.2e-14 53.9 0.3 3.2e-13 49.3 0.1 2.9 2 1 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EDK36384.2 - 2.3e-10 40.4 0.4 7.8e-10 38.7 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EDK36384.2 - 0.0013 18.7 0.1 0.0039 17.1 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK36384.2 - 0.021 15.3 0.0 0.054 13.9 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein MFS_1 PF07690.11 EDK36385.1 - 6.3e-18 64.6 61.2 2.1e-09 36.5 19.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK36385.1 - 9.7e-07 27.5 45.7 0.00021 19.8 16.1 2.9 1 1 2 3 3 3 3 MFS/sugar transport protein LRR_4 PF12799.2 EDK36386.2 - 5.2e-24 83.4 34.8 1.1e-05 24.9 2.5 8.9 4 1 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK36386.2 - 1.1e-16 60.2 28.6 1.3e-05 24.7 0.3 7.8 4 2 4 8 8 8 8 Leucine rich repeat LRR_1 PF00560.28 EDK36386.2 - 5.4e-12 43.9 26.2 0.14 12.3 0.1 11.3 9 2 2 11 11 11 4 Leucine Rich Repeat LRR_7 PF13504.1 EDK36386.2 - 1.2e-09 36.7 26.3 0.52 10.7 0.0 12.1 13 0 0 13 13 13 3 Leucine rich repeat LRR_5 PF13306.1 EDK36386.2 - 3.7e-08 33.1 2.7 0.031 14.0 0.1 4.7 2 1 3 5 5 5 4 Leucine rich repeats (6 copies) FNIP PF05725.7 EDK36386.2 - 3.6e-06 26.8 32.6 0.00011 22.0 1.7 7.4 8 1 0 8 8 8 2 FNIP Repeat LRR_6 PF13516.1 EDK36386.2 - 1.6e-05 24.4 31.4 0.79 9.9 0.0 11.0 12 1 0 12 12 12 3 Leucine Rich repeat EIF_2_alpha PF07541.7 EDK36387.1 - 2.4e-39 133.5 0.3 5.8e-39 132.3 0.1 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 EDK36387.1 - 1.3e-14 53.9 0.7 2.5e-14 53.1 0.5 1.5 1 0 0 1 1 1 1 S1 RNA binding domain tRNA-Thr_ED PF08915.6 EDK36387.1 - 0.0089 16.0 0.2 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase DUF381 PF04038.7 EDK36387.1 - 0.065 13.2 0.0 0.27 11.3 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF381) Pkinase PF00069.20 EDK36388.2 - 5.2e-12 45.4 0.0 6.3e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Rho_GDI PF02115.12 EDK36389.2 - 5.9e-18 65.0 0.3 6.8e-18 64.8 0.2 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Memo PF01875.12 EDK36390.1 - 2.3e-78 262.8 0.1 2.7e-78 262.6 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein NRDD PF13597.1 EDK36390.1 - 0.0064 14.6 0.0 0.0075 14.4 0.0 1.1 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Adaptin_N PF01602.15 EDK36391.2 - 1.6e-100 336.9 9.5 2e-100 336.6 6.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 EDK36391.2 - 6.7e-17 61.5 5.1 7.2e-06 26.1 0.0 5.9 2 2 3 6 6 6 5 HEAT repeats Cnd1 PF12717.2 EDK36391.2 - 8.8e-11 41.9 5.1 1.6e-09 37.8 0.0 3.6 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 EDK36391.2 - 3.4e-08 32.9 2.9 0.045 13.8 0.0 6.1 7 0 0 7 7 7 2 HEAT repeat Arm PF00514.18 EDK36391.2 - 3.7e-05 23.3 2.7 0.41 10.5 0.0 5.3 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EDK36391.2 - 0.0013 19.1 3.2 1.8 9.1 0.0 5.8 5 2 2 7 7 7 2 HEAT-like repeat DUF2435 PF10363.4 EDK36391.2 - 0.0017 18.2 0.5 0.99 9.3 0.1 4.0 2 1 0 3 3 3 1 Protein of unknown function (DUF2435) Atx10homo_assoc PF09759.4 EDK36391.2 - 0.056 13.1 1.4 2 8.1 0.0 3.9 4 1 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain DEAD PF00270.24 EDK36392.2 - 9.5e-22 77.2 0.0 1.2e-19 70.4 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK36392.2 - 1.2e-12 47.5 0.8 5.8e-12 45.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF1998 PF09369.5 EDK36392.2 - 1.2e-10 41.8 1.0 3.3e-10 40.3 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Cellulase PF00150.13 EDK36393.2 - 3.4e-12 46.1 2.8 4.8e-12 45.6 1.9 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) UCH PF00443.24 EDK36394.2 - 2.6e-65 220.1 0.6 6.3e-65 218.9 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK36394.2 - 3.4e-27 95.6 0.8 1.2e-26 93.8 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Y_phosphatase2 PF03162.8 EDK36395.2 - 6.8e-43 145.8 0.0 8.2e-43 145.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 EDK36395.2 - 0.029 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Aminotran_1_2 PF00155.16 EDK36396.2 - 5.7e-63 213.0 0.0 6.8e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EDK36396.2 - 0.0028 16.8 0.0 0.0039 16.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EDK36396.2 - 0.062 12.3 0.0 0.23 10.4 0.0 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EDK36396.2 - 0.07 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V ABC_tran PF00005.22 EDK36397.2 - 6.9e-22 78.2 0.0 5.9e-11 42.8 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EDK36397.2 - 1.9e-06 28.0 1.7 0.033 14.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 EDK36397.2 - 0.00017 21.4 0.1 0.1 12.5 0.0 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.1 EDK36397.2 - 0.011 14.7 0.1 0.62 9.0 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 EDK36397.2 - 0.026 13.9 0.1 2.1 7.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 EDK36397.2 - 0.083 13.0 0.2 3.4 7.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EDK36397.2 - 0.092 13.0 2.5 0.12 12.6 0.8 1.8 2 0 0 2 2 2 0 AAA domain BSD PF03909.12 EDK36398.2 - 8.7e-16 57.4 0.2 8.7e-16 57.4 0.1 2.5 2 0 0 2 2 2 1 BSD domain Globin PF00042.17 EDK36398.2 - 0.0048 17.2 1.1 0.0048 17.2 0.7 2.5 2 1 0 2 2 2 1 Globin Baculo_PEP_C PF04513.7 EDK36398.2 - 0.75 9.6 5.8 2.7 7.7 0.4 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cyclin_N PF00134.18 EDK36399.2 - 8.6e-05 22.1 0.3 0.00017 21.1 0.2 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EDK36399.2 - 0.0014 19.0 1.0 0.0033 17.8 0.7 1.7 1 1 0 1 1 1 1 Cyclin Metallophos PF00149.23 EDK36401.2 - 4.4e-13 49.0 0.2 1.4e-12 47.4 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase G-alpha PF00503.15 EDK36402.2 - 2e-117 392.2 1.9 2.4e-117 391.9 1.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EDK36402.2 - 9.8e-17 60.7 0.6 9.1e-12 44.5 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 EDK36402.2 - 0.00047 20.6 0.3 1.3 9.5 0.0 2.9 2 1 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 EDK36402.2 - 0.0006 19.0 1.4 0.02 14.0 0.1 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EDK36402.2 - 0.021 14.7 0.0 7.7 6.5 0.0 2.8 3 0 0 3 3 3 0 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK36402.2 - 0.061 12.7 0.1 2.1 7.7 0.0 2.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 EDK36402.2 - 0.11 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_M16_C PF05193.16 EDK36403.1 - 6e-22 78.1 0.2 1.3e-21 77.1 0.0 1.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EDK36403.1 - 3e-11 43.2 0.3 1.8e-09 37.4 0.2 2.4 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) Elong-fact-P_C PF09285.6 EDK36403.1 - 0.1 11.9 0.5 0.28 10.5 0.4 1.7 1 0 0 1 1 1 0 Elongation factor P, C-terminal Ribosomal_S7 PF00177.16 EDK36405.2 - 2e-32 111.8 0.5 3.4e-32 111.0 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF3366 PF11846.3 EDK36405.2 - 0.051 13.4 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) CybS PF05328.7 EDK36406.2 - 3.1e-54 182.1 0.1 3.6e-54 181.9 0.1 1.0 1 0 0 1 1 1 1 CybS Ribosomal_S14 PF00253.16 EDK36407.1 - 9e-10 37.7 0.0 2.4e-09 36.4 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Lum_binding PF00677.12 EDK36408.2 - 4.5e-45 151.4 3.7 1.3e-21 76.3 0.1 2.2 2 0 0 2 2 2 2 Lumazine binding domain Spore_GerAC PF05504.6 EDK36408.2 - 0.013 15.3 0.6 0.019 14.7 0.4 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal KCNQC3-Ank-G_bd PF11956.3 EDK36408.2 - 0.13 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 Proteasome PF00227.21 EDK36409.1 - 3.9e-40 137.1 0.0 4.6e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit OB_NTP_bind PF07717.11 EDK36410.2 - 5.6e-29 100.2 0.0 1.6e-28 98.7 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EDK36410.2 - 1.3e-25 89.3 0.0 4.8e-25 87.5 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) S1 PF00575.18 EDK36410.2 - 4e-12 46.0 0.4 4e-12 46.0 0.3 1.9 2 0 0 2 2 1 1 S1 RNA binding domain Helicase_C PF00271.26 EDK36410.2 - 4.3e-12 45.7 0.0 1.5e-11 44.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK36410.2 - 1.4e-08 34.3 0.2 2.8e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK36410.2 - 2.2e-06 27.8 0.0 5.2e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EDK36410.2 - 0.0023 17.8 0.4 0.053 13.4 0.3 2.6 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 EDK36410.2 - 0.0056 15.6 0.0 0.012 14.5 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 EDK36410.2 - 0.0082 15.8 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 EDK36410.2 - 0.014 15.2 0.1 2.2 8.0 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SRP54 PF00448.17 EDK36410.2 - 0.034 13.5 0.8 0.11 11.8 0.6 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 EDK36410.2 - 0.04 14.2 8.0 0.061 13.6 0.1 3.7 3 1 0 3 3 3 0 ABC transporter Sigma54_activ_2 PF14532.1 EDK36410.2 - 0.042 13.8 0.0 0.78 9.7 0.0 2.8 4 0 0 4 4 3 0 Sigma-54 interaction domain Miro PF08477.8 EDK36410.2 - 0.052 14.0 1.4 0.18 12.3 0.2 2.6 2 1 0 2 2 2 0 Miro-like protein AAA_25 PF13481.1 EDK36410.2 - 0.098 12.0 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 EDK36410.2 - 0.31 10.5 0.0 0.31 10.5 0.0 2.8 2 1 0 2 2 1 0 AAA domain Cellulase PF00150.13 EDK36411.2 - 5.6e-08 32.3 0.0 1.1e-06 28.0 0.1 2.6 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF2179 PF10035.4 EDK36411.2 - 0.013 15.1 0.2 0.026 14.0 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) DNA_primase_S PF01896.14 EDK36413.2 - 1.9e-53 180.1 0.3 4.3e-53 179.0 0.2 1.6 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit WD40 PF00400.27 EDK36414.2 - 1.4e-13 50.1 6.2 0.0013 18.5 0.1 7.2 7 1 0 7 7 7 5 WD domain, G-beta repeat PQQ_2 PF13360.1 EDK36414.2 - 1.4e-05 24.7 2.4 0.00077 18.9 1.6 2.8 1 1 1 2 2 2 1 PQQ-like domain Apc4_WD40 PF12894.2 EDK36414.2 - 0.0032 16.9 0.0 2.6 7.6 0.0 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.16 EDK36414.2 - 0.0089 15.5 0.3 4.1 7.1 0.0 3.0 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_3 PF13570.1 EDK36414.2 - 0.035 14.3 0.1 7.3 7.0 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain Syd PF07348.7 EDK36414.2 - 0.069 12.4 0.6 3.7 6.8 0.2 2.7 2 1 1 3 3 3 0 Syd protein (SUKH-2) Prenyltransf PF01255.14 EDK36415.2 - 7.4e-73 244.3 0.0 8.9e-73 244.0 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase HisG PF01634.13 EDK36416.1 - 2.9e-53 179.8 0.3 3.9e-53 179.3 0.2 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 EDK36416.1 - 1.2e-26 92.4 0.1 2.8e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain Sec7_N PF12783.2 EDK36416.1 - 0.071 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Aminotran_5 PF00266.14 EDK36417.2 - 4.1e-20 71.8 0.0 5.3e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EDK36417.2 - 2.5e-05 22.7 0.0 3.2e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EDK36417.2 - 0.011 14.7 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II PCI PF01399.22 EDK36418.2 - 5.8e-17 61.9 0.8 5.8e-17 61.9 0.5 2.4 2 1 0 2 2 2 1 PCI domain Apc9 PF12856.2 EDK36418.2 - 0.0077 16.2 0.9 0.039 14.0 0.6 2.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 Glyco_hydro_72 PF03198.9 EDK36419.2 - 7.6e-136 452.1 7.2 9.8e-136 451.8 5.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.12 EDK36419.2 - 0.00012 21.0 0.1 0.00023 20.1 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.13 EDK36419.2 - 0.0012 18.1 0.9 0.011 14.9 0.6 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Borrelia_orfD PF02999.9 EDK36419.2 - 0.31 11.1 2.2 0.22 11.6 0.2 1.7 2 0 0 2 2 2 0 Borrelia orf-D family DUF3774 PF12609.3 EDK36419.2 - 0.44 11.4 3.9 8.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Wound-induced protein Adap_comp_sub PF00928.16 EDK36420.2 - 5.2e-86 287.9 0.1 6.5e-86 287.6 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EDK36420.2 - 5.1e-09 35.9 2.0 1e-08 34.9 1.4 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF2458 PF10454.4 EDK36421.1 - 4.2e-45 153.3 8.9 6.4e-45 152.7 6.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) DGCR6 PF07324.6 EDK36421.1 - 0.018 14.5 3.6 0.031 13.7 2.5 1.3 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein Spectrin PF00435.16 EDK36421.1 - 0.056 13.7 1.6 0.14 12.4 1.0 1.8 1 1 0 1 1 1 0 Spectrin repeat vATP-synt_E PF01991.13 EDK36421.1 - 0.92 8.7 9.9 1.2 8.3 4.0 2.0 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit ILVD_EDD PF00920.16 EDK36422.2 - 1.4e-207 690.2 0.2 1.6e-207 690.0 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family UQ_con PF00179.21 EDK36423.2 - 3.1e-34 117.3 0.2 6.3e-34 116.4 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EDK36423.2 - 0.13 12.1 2.4 0.27 11.1 0.1 2.6 2 1 0 2 2 2 0 RWD domain NPV_P10 PF05531.7 EDK36423.2 - 0.34 11.2 13.2 4.3 7.6 0.5 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Ribosomal_S28e PF01200.13 EDK36424.1 - 4.7e-34 115.9 2.9 5.1e-34 115.8 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e EB1 PF03271.12 EDK36425.2 - 6.7e-16 58.0 0.1 1.3e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 EDK36425.2 - 1.2e-07 31.7 0.6 3.3e-07 30.3 0.1 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain DUF3480 PF11979.3 EDK36425.2 - 0.031 12.9 0.0 0.047 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) zf-C2H2_jaz PF12171.3 EDK36426.2 - 0.016 15.3 0.1 0.034 14.2 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 EDK36426.2 - 0.023 15.0 0.3 0.075 13.4 0.2 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK36426.2 - 0.043 14.1 0.3 0.13 12.6 0.2 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-BED PF02892.10 EDK36426.2 - 0.081 12.7 0.5 0.2 11.4 0.3 1.7 1 0 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.1 EDK36426.2 - 0.083 13.2 2.0 10 6.6 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double domain PIN_3 PF13470.1 EDK36427.2 - 0.084 13.5 0.0 0.087 13.5 0.0 1.1 1 0 0 1 1 1 0 PIN domain DUF896 PF05979.7 EDK36427.2 - 0.44 10.1 4.5 0.51 9.9 2.2 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) Cyclin PF08613.6 EDK36428.2 - 6.1e-39 133.8 0.6 6.1e-39 133.8 0.4 1.6 2 0 0 2 2 2 1 Cyclin RTA1 PF04479.8 EDK36429.2 - 7.9e-49 166.1 7.7 1.4e-48 165.3 5.3 1.3 1 0 0 1 1 1 1 RTA1 like protein PIG-P PF08510.7 EDK36429.2 - 0.029 13.9 2.3 1.1 8.8 0.0 2.6 2 0 0 2 2 2 0 PIG-P FixQ PF05545.6 EDK36429.2 - 0.26 10.9 4.3 0.72 9.5 0.5 2.8 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DGF-1_4 PF11024.3 EDK36429.2 - 1.6 9.1 11.3 0.73 10.2 5.4 2.0 1 1 1 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 RTA1 PF04479.8 EDK36430.2 - 1.4e-38 132.6 12.7 1.4e-38 132.6 8.8 1.3 2 0 0 2 2 2 1 RTA1 like protein WD40 PF00400.27 EDK36432.2 - 2.7e-19 68.2 7.9 0.00042 20.0 0.0 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat Sec16_C PF12931.2 EDK36432.2 - 0.0013 18.5 0.1 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 SRA1 PF07304.6 EDK36432.2 - 0.0032 17.2 0.0 0.0032 17.2 0.0 2.6 2 1 1 3 3 3 1 Steroid receptor RNA activator (SRA1) Glyco_hydro_65m PF03632.10 EDK36433.2 - 1e-83 281.0 1.8 5.6e-83 278.6 1.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 EDK36433.2 - 2e-28 99.3 0.4 3.5e-28 98.5 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain F5_F8_type_C PF00754.20 EDK36433.2 - 0.0013 18.5 0.2 0.0057 16.4 0.1 2.1 2 0 0 2 2 2 1 F5/8 type C domain Glyco_hydro_65C PF03633.10 EDK36433.2 - 0.047 13.7 0.4 0.23 11.5 0.0 2.5 3 0 0 3 3 3 0 Glycosyl hydrolase family 65, C-terminal domain MIS13 PF08202.6 EDK36434.2 - 1.7e-57 194.8 5.6 1.7e-57 194.8 3.9 2.1 2 1 0 2 2 2 1 Mis12-Mtw1 protein family MRP-S33 PF08293.6 EDK36436.1 - 2.9e-31 107.2 1.6 3.5e-31 107.0 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ion_trans PF00520.26 EDK36437.2 - 1.3e-92 308.5 108.2 2.6e-35 121.5 5.6 6.7 7 0 0 7 7 7 5 Ion transport protein PKD_channel PF08016.7 EDK36437.2 - 0.00028 19.4 5.7 0.00028 19.4 3.9 7.4 7 2 0 7 7 7 2 Polycystin cation channel Baculo_11_kDa PF06143.6 EDK36437.2 - 0.087 12.1 13.8 0.15 11.4 0.2 4.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family DUF2973 PF11189.3 EDK36437.2 - 0.22 11.2 2.1 6.6 6.5 0.2 4.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) PspB PF06667.7 EDK36437.2 - 0.29 11.1 5.5 4.8 7.1 0.1 3.7 3 0 0 3 3 3 0 Phage shock protein B zf-ZPR1 PF03367.8 EDK36438.1 - 8.3e-116 382.6 0.4 1.3e-57 193.4 0.1 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain SF-assemblin PF06705.6 EDK36438.1 - 0.0075 15.4 0.2 2.4 7.2 0.0 2.5 2 0 0 2 2 2 2 SF-assemblin/beta giardin Cytochrom_C_2 PF01322.15 EDK36438.1 - 0.046 14.2 4.8 3.7 8.0 0.1 3.8 4 0 0 4 4 4 0 Cytochrome C' zinc_ribbon_4 PF13717.1 EDK36438.1 - 0.15 11.7 4.6 4.2 7.1 0.1 3.8 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 EDK36438.1 - 0.25 10.9 4.9 5 6.7 0.1 3.7 3 1 0 3 3 3 0 zinc-ribbon domain WD40 PF00400.27 EDK36439.2 - 1.1e-57 189.9 30.5 4.5e-10 39.0 1.5 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.2 EDK36439.2 - 8.6e-14 51.0 1.6 1.7e-13 50.0 1.1 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 EDK36439.2 - 1.2e-12 46.7 16.4 0.0077 14.4 0.2 6.2 1 1 5 6 6 6 6 Nucleoporin Nup120/160 F-box PF00646.28 EDK36439.2 - 6.3e-12 44.8 1.9 1.3e-11 43.7 0.9 1.9 1 1 0 1 1 1 1 F-box domain BBS2_Mid PF14783.1 EDK36439.2 - 6.3e-06 25.9 0.1 0.029 14.1 0.0 4.0 2 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.6 EDK36439.2 - 0.0011 18.7 0.7 0.44 10.2 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PRANC PF09372.5 EDK36439.2 - 0.056 13.4 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 PRANC domain CBM_21 PF03370.8 EDK36440.2 - 2.6e-37 127.2 2.1 4.4e-37 126.5 1.4 1.4 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit LCM PF04072.9 EDK36441.2 - 8.2e-24 84.1 0.0 1.5e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.1 EDK36441.2 - 1e-15 57.2 1.0 7e-08 32.1 0.0 5.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 EDK36441.2 - 3.6e-14 52.4 0.0 7.2e-06 26.0 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 EDK36441.2 - 1.1e-08 34.7 0.0 0.13 12.2 0.0 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 EDK36441.2 - 8.1e-07 28.9 2.4 4.1 7.7 0.0 6.0 5 1 1 6 6 6 2 Kelch motif Kelch_2 PF07646.10 EDK36441.2 - 0.1 12.3 5.5 11 5.9 0.0 4.9 5 1 1 6 6 6 0 Kelch motif Zn_clus PF00172.13 EDK36443.2 - 3e-08 33.4 9.9 5.5e-08 32.5 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain APH PF01636.18 EDK36445.2 - 2.5e-08 33.9 0.0 2e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sedlin_N PF04628.8 EDK36446.2 - 1.4e-44 151.1 0.0 1.6e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 EDK36446.2 - 6.1e-05 22.7 0.2 0.00019 21.1 0.1 1.8 1 1 0 1 1 1 1 Sybindin-like family Tachykinin PF02202.11 EDK36446.2 - 1.3 8.8 0.0 1.3 8.8 0.0 2.6 3 0 0 3 3 3 0 Tachykinin family DAHP_synth_1 PF00793.15 EDK36448.2 - 9.3e-15 54.0 0.0 1.7e-14 53.1 0.0 1.4 1 1 0 1 1 1 1 DAHP synthetase I family PITH PF06201.8 EDK36450.2 - 1.1e-29 103.1 0.1 1.9e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.15 EDK36450.2 - 8.1e-23 80.0 0.0 1.8e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK36450.2 - 3.9e-10 39.6 0.0 6.5e-08 32.5 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EDK36450.2 - 1.6e-07 31.5 0.4 1.3e-06 28.5 0.1 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.16 EDK36450.2 - 7.1e-06 25.7 0.1 2.7e-05 23.8 0.0 2.1 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_9 PF14595.1 EDK36450.2 - 3.2e-05 23.4 0.0 6.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 EDK36450.2 - 5.3e-05 22.8 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 EDK36450.2 - 7.2e-05 22.7 0.1 0.00036 20.4 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin-like Glutaredoxin PF00462.19 EDK36450.2 - 0.0017 18.3 1.2 0.0035 17.2 0.2 2.0 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_3 PF13192.1 EDK36450.2 - 0.0037 17.0 0.1 0.0076 16.0 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.9 EDK36450.2 - 0.016 15.4 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) TrbC_Ftype PF09673.5 EDK36450.2 - 0.032 13.8 0.0 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein LETM1 PF07766.8 EDK36451.2 - 2.9e-100 334.7 3.6 4.8e-100 334.0 2.5 1.3 1 0 0 1 1 1 1 LETM1-like protein dUTPase PF00692.14 EDK36452.1 - 4.8e-43 145.6 0.0 5.7e-43 145.4 0.0 1.1 1 0 0 1 1 1 1 dUTPase HMG_box PF00505.14 EDK36453.2 - 3.9e-05 23.8 5.4 0.12 12.6 1.3 3.7 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.5 EDK36453.2 - 0.002 18.4 1.6 2.2 8.6 0.2 3.6 3 0 0 3 3 3 2 HMG-box domain DEAD PF00270.24 EDK36455.1 - 8.7e-45 152.2 1.3 1.4e-44 151.5 0.6 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK36455.1 - 1.8e-28 98.2 0.1 1.3e-27 95.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK36455.1 - 7.3e-06 25.9 0.1 1.6e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EDK36455.1 - 0.00067 19.3 1.4 0.0012 18.5 0.2 1.9 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 EDK36455.1 - 0.0023 18.0 0.0 0.0066 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EDK36455.1 - 0.0039 16.8 0.1 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.1 EDK36455.1 - 0.0071 15.4 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.9 EDK36455.1 - 0.0094 15.7 0.2 0.11 12.2 0.1 2.2 1 1 0 1 1 1 1 Flavivirus DEAD domain UvrD-helicase PF00580.16 EDK36455.1 - 0.059 12.6 0.8 0.18 11.0 0.3 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Helicase_C_2 PF13307.1 EDK36455.1 - 0.084 12.8 0.1 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 Helicase C-terminal domain Glyco_transf_8 PF01501.15 EDK36456.2 - 1.4e-27 96.6 0.6 5.8e-22 78.2 0.1 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 8 tRNA_U5-meth_tr PF05958.6 EDK36457.2 - 3.1e-25 88.6 1.1 2.1e-24 85.8 0.8 2.0 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 EDK36457.2 - 8.4e-12 44.9 0.1 1.7e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.15 EDK36457.2 - 4.9e-11 42.2 0.1 1.2e-10 40.9 0.0 1.8 2 0 0 2 2 2 1 TRAM domain Methyltransf_18 PF12847.2 EDK36457.2 - 1.1e-06 29.1 0.0 2.8e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36457.2 - 2.5e-06 27.5 0.0 4.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 EDK36457.2 - 6.5e-06 25.7 0.3 1.3e-05 24.8 0.2 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EDK36457.2 - 2.5e-05 23.7 0.1 4.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EDK36457.2 - 6.5e-05 22.1 0.4 0.00011 21.4 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.11 EDK36457.2 - 6.9e-05 22.5 0.2 0.00014 21.5 0.2 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.12 EDK36457.2 - 0.0002 20.4 0.1 0.00042 19.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 EDK36457.2 - 0.00038 19.6 0.1 0.00089 18.4 0.1 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EDK36457.2 - 0.00042 20.6 0.0 0.00085 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36457.2 - 0.0025 18.2 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EDK36457.2 - 0.028 14.0 0.1 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 PAP2 PF01569.16 EDK36458.2 - 1.6e-19 69.8 2.4 1.6e-19 69.8 1.7 1.9 2 0 0 2 2 2 1 PAP2 superfamily Ras PF00071.17 EDK36459.2 - 4.5e-46 156.1 0.0 6.3e-46 155.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK36459.2 - 1.9e-17 63.8 0.0 3.8e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK36459.2 - 3.3e-06 26.4 0.0 5.6e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 EDK36459.2 - 0.029 14.4 0.0 0.37 10.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain CBM_4_9 PF02018.12 EDK36459.2 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain DUF2401 PF10287.4 EDK36461.1 - 2.6e-103 344.5 3.6 2.6e-103 344.5 2.5 2.1 2 0 0 2 2 2 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 EDK36461.1 - 4e-30 103.7 0.5 1.5e-29 101.9 0.1 2.3 2 0 0 2 2 2 1 Glycine-rich protein domain (DUF2403) DUF3246 PF11596.3 EDK36461.1 - 0.00043 19.6 12.0 0.00043 19.6 8.3 2.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3246) GTSE1_N PF15259.1 EDK36461.1 - 0.0081 16.1 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 G-2 and S-phase expressed 1 FGGY_N PF00370.16 EDK36462.2 - 2.3e-18 66.4 0.0 3.4e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 EDK36462.2 - 2.5e-15 56.6 0.0 3.9e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.15 EDK36462.2 - 0.0028 17.0 0.0 0.043 13.1 0.0 2.2 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Arg_repressor_C PF02863.13 EDK36462.2 - 0.014 14.8 0.0 0.18 11.3 0.0 2.2 2 0 0 2 2 2 0 Arginine repressor, C-terminal domain Zn_clus PF00172.13 EDK36463.2 - 4.1e-06 26.6 17.9 6.5e-06 25.9 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.23 EDK36464.1 - 2.2e-39 134.9 0.4 2.9e-39 134.5 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NAD_binding_10 PF13460.1 EDK36465.1 - 2.3e-14 53.7 0.0 3.6e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EDK36465.1 - 4.5e-13 49.0 0.0 6.9e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 EDK36465.1 - 1.4e-12 47.6 0.5 3.4e-12 46.3 0.1 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK36465.1 - 6.3e-10 38.2 0.1 1.1e-09 37.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EDK36465.1 - 6.6e-08 31.7 0.0 3.1e-06 26.2 0.0 2.6 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EDK36465.1 - 0.00012 21.1 0.9 0.28 10.0 0.0 3.0 1 1 2 3 3 3 2 Male sterility protein Saccharop_dh PF03435.13 EDK36465.1 - 0.0032 16.5 0.0 0.0047 15.9 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Polysacc_synt_2 PF02719.10 EDK36465.1 - 0.079 11.8 0.0 0.18 10.6 0.0 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DDE_Tnp_1_3 PF13612.1 EDK36465.1 - 0.087 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Transposase DDE domain OHCU_decarbox PF09349.5 EDK36466.2 - 6.6e-40 136.9 0.0 7.9e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase ATP-synt_ab PF00006.20 EDK36467.1 - 3.2e-120 399.3 0.0 4.8e-120 398.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EDK36467.1 - 1.2e-18 67.5 0.2 2.2e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EDK36467.1 - 9.5e-15 54.5 2.8 2.2e-14 53.4 1.4 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.1 EDK36467.1 - 0.0016 18.3 0.0 0.0091 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mit_KHE1 PF10173.4 EDK36469.1 - 5.2e-65 218.8 0.4 7.1e-65 218.3 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related MARVEL PF01284.18 EDK36470.2 - 9e-06 25.5 4.1 9e-06 25.5 2.8 1.8 2 0 0 2 2 2 1 Membrane-associating domain AA_permease_2 PF13520.1 EDK36470.2 - 0.82 8.1 5.3 4.8 5.6 3.7 1.8 1 1 0 1 1 1 0 Amino acid permease Cullin PF00888.17 EDK36471.2 - 1e-148 496.5 17.9 1e-148 496.5 12.4 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 EDK36471.2 - 9.5e-25 86.2 4.3 9.5e-25 86.2 3.0 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain WD40 PF00400.27 EDK36472.2 - 1.8e-30 103.6 14.6 1.9e-05 24.3 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat SNF2_N PF00176.18 EDK36473.2 - 8.5e-37 126.5 2.8 1.6e-31 109.2 0.0 3.0 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK36473.2 - 3.7e-07 29.9 0.0 1.5e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain BRO1 PF03097.13 EDK36474.2 - 3.1e-124 414.5 10.3 5.7e-124 413.6 7.2 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EDK36474.2 - 2.6e-33 115.2 13.7 9e-33 113.4 9.4 1.9 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV Glyco_hydro_16 PF00722.16 EDK36475.2 - 2.5e-42 144.2 7.6 2.5e-42 144.2 5.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.14 EDK36475.2 - 0.054 13.4 13.3 0.11 12.4 9.2 1.4 1 0 0 1 1 1 0 Chitin recognition protein Nodulin_late PF07127.6 EDK36475.2 - 0.15 12.2 0.8 0.26 11.4 0.6 1.4 1 0 0 1 1 1 0 Late nodulin protein Coatomer_WDAD PF04053.9 EDK36476.2 - 5.2e-146 486.9 6.3 1e-145 485.9 4.4 1.5 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 EDK36476.2 - 5e-78 262.5 0.0 7.2e-78 261.9 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 EDK36476.2 - 2.4e-54 179.3 16.6 8.8e-11 41.2 0.0 8.6 9 0 0 9 9 9 6 WD domain, G-beta repeat Nup160 PF11715.3 EDK36476.2 - 0.00043 18.5 6.7 0.2 9.7 0.0 3.8 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Metallophos PF00149.23 EDK36477.2 - 2.3e-36 125.0 0.0 3.6e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 EDK36477.2 - 4.2e-23 80.7 3.5 5.4e-21 74.0 0.0 2.5 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EDK36477.2 - 9.1e-21 72.5 5.1 3.1e-07 29.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 EDK36477.2 - 1.3e-16 59.0 2.4 2.8e-05 23.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat PPP5 PF08321.7 EDK36477.2 - 1.2e-15 57.2 1.7 4.3e-13 49.1 0.3 3.5 3 1 0 3 3 3 1 PPP5 TPR repeat region TPR_17 PF13431.1 EDK36477.2 - 3.2e-09 36.2 0.4 0.00038 20.4 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EDK36477.2 - 2.2e-08 34.5 0.0 2.3e-06 28.1 0.0 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36477.2 - 3.3e-06 27.3 0.1 0.00052 20.2 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK36477.2 - 5.7e-06 25.7 4.6 0.33 10.8 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 EDK36477.2 - 0.00016 21.5 1.8 0.083 12.8 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36477.2 - 0.00024 21.4 0.0 0.055 14.1 0.0 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat MIT PF04212.13 EDK36477.2 - 0.0069 16.2 2.0 0.98 9.3 0.0 3.4 2 1 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 EDK36477.2 - 0.019 14.7 0.3 0.77 9.7 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 EDK36477.2 - 0.071 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EDK36477.2 - 0.1 12.4 0.2 7.3 6.5 0.0 3.3 2 1 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 EDK36477.2 - 0.55 10.8 3.1 9.8 6.8 0.2 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat CHCH PF06747.8 EDK36478.1 - 1.2e-07 31.4 5.7 2.1e-07 30.6 3.9 1.4 1 0 0 1 1 1 1 CHCH domain DB PF01682.14 EDK36478.1 - 0.062 13.3 1.2 0.063 13.3 0.8 1.1 1 0 0 1 1 1 0 DB module Cmc1 PF08583.5 EDK36478.1 - 0.2 11.4 7.6 0.36 10.6 5.3 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Scm3 PF10384.4 EDK36479.2 - 3.9e-24 83.8 1.0 6.8e-24 83.1 0.7 1.4 1 0 0 1 1 1 1 Centromere protein Scm3 zf-C2H2_4 PF13894.1 EDK36479.2 - 0.045 14.0 0.4 0.045 14.0 0.2 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger Peptidase_M41 PF01434.13 EDK36481.2 - 3.5e-74 248.8 0.3 6.5e-74 247.9 0.2 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EDK36481.2 - 4.7e-43 146.5 0.0 1.6e-42 144.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EDK36481.2 - 5.4e-05 24.0 2.1 0.00018 22.3 0.1 3.0 3 1 0 3 3 2 1 AAA domain AAA_22 PF13401.1 EDK36481.2 - 0.00022 21.3 0.3 0.17 11.9 0.1 3.2 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.8 EDK36481.2 - 0.0017 17.1 0.0 0.0035 16.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 EDK36481.2 - 0.0047 16.6 0.7 0.014 15.1 0.5 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 EDK36481.2 - 0.0068 16.1 0.7 0.028 14.1 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EDK36481.2 - 0.0089 15.0 0.0 0.018 14.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 EDK36481.2 - 0.0089 15.4 0.1 0.041 13.2 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.1 EDK36481.2 - 0.015 15.2 0.2 0.064 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 EDK36481.2 - 0.027 13.5 0.0 0.069 12.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_2 PF07724.9 EDK36481.2 - 0.073 12.9 0.0 0.073 12.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EDK36481.2 - 0.076 12.8 0.0 0.24 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Inp1 PF12634.2 EDK36481.2 - 0.091 12.4 2.6 0.064 12.9 0.2 2.0 3 0 0 3 3 3 0 Inheritance of peroxisomes protein 1 AAA_18 PF13238.1 EDK36481.2 - 0.12 12.6 0.0 0.12 12.6 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.1 EDK36481.2 - 0.22 10.8 3.6 0.32 10.3 0.8 2.4 1 1 1 2 2 2 0 AAA domain Glyco_transf_15 PF01793.11 EDK36483.2 - 8.6e-145 481.8 10.6 1.1e-144 481.4 7.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Glyco_transf_15 PF01793.11 EDK36484.2 - 9e-146 485.0 12.9 1.1e-145 484.7 8.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase RabGAP-TBC PF00566.13 EDK36485.2 - 1.5e-32 112.8 1.1 2.2e-32 112.2 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NPL4 PF05021.10 EDK36486.2 - 1.5e-114 382.2 0.0 2.5e-114 381.5 0.0 1.3 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 EDK36486.2 - 1.4e-72 242.1 1.0 2.2e-72 241.5 0.7 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 EDK36486.2 - 1.3e-06 28.5 0.0 3.3e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 HSP70 PF00012.15 EDK36487.1 - 7.9e-144 479.8 0.0 9.6e-144 479.5 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EDK36487.1 - 3.2e-13 48.9 0.1 1.7e-12 46.5 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 EDK36487.1 - 0.0083 15.9 3.2 0.18 11.6 0.2 3.1 2 2 0 2 2 2 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.17 EDK36487.1 - 0.14 11.9 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain HSP70 PF00012.15 EDK36488.1 - 5.3e-12 44.4 2.5 5.3e-12 44.4 1.7 1.8 1 1 1 2 2 2 1 Hsp70 protein Trans_reg_C PF00486.23 EDK36488.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal Sec2p PF06428.6 EDK36488.1 - 0.24 11.2 7.6 0.08 12.8 0.7 2.5 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p IncA PF04156.9 EDK36488.1 - 2.5 7.6 8.9 12 5.4 6.0 1.9 1 1 0 1 1 1 0 IncA protein Ribosomal_60s PF00428.14 EDK36488.1 - 9.2 6.7 14.0 26 5.2 9.7 1.8 1 1 0 1 1 1 0 60s Acidic ribosomal protein Pkinase PF00069.20 EDK36489.2 - 1e-43 149.3 0.7 2.3e-24 85.9 0.4 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36489.2 - 4.7e-17 61.9 1.9 1.8e-11 43.6 0.5 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DUF4611 PF15387.1 EDK36489.2 - 1.7 8.8 10.0 5.2 7.2 6.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.6 EDK36489.2 - 2.9 5.6 9.3 0.36 8.6 1.0 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF566 PF04484.7 EDK36489.2 - 4.3 6.7 9.2 6.9 6.0 6.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) Radical_SAM PF04055.16 EDK36490.2 - 1.8e-16 60.7 0.1 2.8e-16 60.1 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily MBA1 PF07961.6 EDK36491.2 - 5.6e-73 244.6 0.0 7e-73 244.3 0.0 1.0 1 0 0 1 1 1 1 MBA1-like protein zf-CCCH PF00642.19 EDK36492.2 - 0.00034 20.2 1.4 0.00055 19.5 1.0 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) NOG1 PF06858.9 EDK36493.1 - 2.5e-27 94.5 0.4 5.2e-27 93.5 0.3 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.6 EDK36493.1 - 9.1e-27 92.5 1.2 2.5e-26 91.1 0.8 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.18 EDK36493.1 - 1.6e-15 57.0 0.0 4.1e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK36493.1 - 2.8e-09 36.4 0.0 6.2e-09 35.3 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 EDK36493.1 - 0.00035 21.0 0.2 0.0027 18.2 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 EDK36493.1 - 0.0011 18.1 1.1 0.0014 17.8 0.0 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 EDK36493.1 - 0.014 15.2 0.7 6.9 6.4 0.0 3.0 2 1 1 3 3 3 0 Dynamin family Anp1 PF03452.9 EDK36494.2 - 8.9e-114 379.1 0.0 1.1e-113 378.9 0.0 1.1 1 0 0 1 1 1 1 Anp1 FtsH_ext PF06480.10 EDK36494.2 - 0.057 13.5 0.2 0.1 12.8 0.1 1.6 1 1 0 1 1 1 0 FtsH Extracellular Glycos_transf_2 PF00535.21 EDK36494.2 - 0.072 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 Zn_clus PF00172.13 EDK36496.2 - 6.3e-06 25.9 12.4 1.1e-05 25.2 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CD47 PF04549.9 EDK36496.2 - 0.85 9.6 4.6 1.4 8.9 3.2 1.2 1 0 0 1 1 1 0 CD47 transmembrane region RRM_6 PF14259.1 EDK36497.2 - 3.4e-05 23.7 0.0 0.0002 21.2 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK36497.2 - 0.01 15.4 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.10 EDK36497.2 - 0.024 14.1 0.8 0.1 12.1 0.5 2.2 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Flavoprotein PF02441.14 EDK36498.2 - 5.6e-41 139.2 0.2 9e-41 138.5 0.1 1.3 1 0 0 1 1 1 1 Flavoprotein NOA36 PF06524.7 EDK36498.2 - 5.5 6.1 25.5 8.3 5.5 17.7 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 EDK36498.2 - 7.1 4.4 27.2 11 3.7 18.9 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 EDK36498.2 - 7.4 5.1 43.6 0.01 14.6 22.3 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2457) MAP65_ASE1 PF03999.7 EDK36499.2 - 2.9e-44 151.7 25.7 2.9e-44 151.7 17.8 2.5 2 0 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) PQ-loop PF04193.9 EDK36501.2 - 6.2e-38 128.1 13.6 5.8e-20 70.6 1.4 3.2 3 0 0 3 3 3 2 PQ loop repeat Pho86 PF11124.3 EDK36501.2 - 0.098 11.6 0.3 0.18 10.7 0.2 1.4 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 MtN3_slv PF03083.11 EDK36501.2 - 0.25 11.2 0.1 0.25 11.2 0.1 2.8 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Pyridoxal_deC PF00282.14 EDK36502.2 - 4.3e-21 74.7 0.0 6.4e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.12 EDK36502.2 - 2.3e-08 33.5 0.0 3.5e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EDK36502.2 - 4.4e-08 32.2 0.0 3.4e-07 29.3 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EDK36502.2 - 0.00049 18.4 0.0 0.00078 17.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SLA_LP_auto_ag PF05889.8 EDK36502.2 - 0.027 12.9 0.0 0.14 10.6 0.0 1.8 2 0 0 2 2 2 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) HDA2-3 PF11496.3 EDK36503.2 - 7.5e-81 271.1 0.6 1.5e-80 270.1 0.4 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 FlaC_arch PF05377.6 EDK36503.2 - 0.38 10.6 7.6 5.1 7.0 1.2 3.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 EDK36503.2 - 0.39 9.8 3.2 0.28 10.3 0.5 1.9 3 0 0 3 3 3 0 Reovirus sigma C capsid protein HlyD PF00529.15 EDK36503.2 - 3.4 6.8 14.1 5.6 6.1 9.8 1.3 1 0 0 1 1 1 0 HlyD family secretion protein EF-hand_4 PF12763.2 EDK36504.2 - 4e-06 26.5 0.0 1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EDK36504.2 - 0.034 13.4 0.0 0.07 12.4 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 EDK36504.2 - 0.039 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair NOB1_Zn_bind PF08772.6 EDK36505.2 - 2e-28 98.0 0.8 4.7e-28 96.8 0.6 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.5 EDK36505.2 - 0.024 14.5 1.8 0.062 13.2 1.2 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-RING_3 PF14369.1 EDK36505.2 - 0.12 12.3 1.6 0.23 11.4 1.1 1.4 1 0 0 1 1 1 0 zinc-finger PLRV_ORF5 PF01690.12 EDK36505.2 - 0.71 8.9 22.3 0.08 12.0 12.3 1.6 2 0 0 2 2 2 0 Potato leaf roll virus readthrough protein GST_N_3 PF13417.1 EDK36506.2 - 2.7e-10 40.3 0.0 5.2e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EDK36506.2 - 4.5e-10 39.3 0.4 1.2e-09 38.0 0.3 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 EDK36506.2 - 3.6e-09 36.5 0.0 7e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EDK36506.2 - 5.4e-09 36.1 0.0 1.1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EDK36506.2 - 3.5e-08 33.8 0.0 1e-07 32.3 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EDK36506.2 - 2.4e-05 24.1 0.0 4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EDK36507.2 - 5.3e-09 35.9 0.0 6.9e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EDK36507.2 - 3.5e-07 29.9 0.0 5.1e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EDK36507.2 - 3.8e-07 30.4 0.0 5.9e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EDK36508.1 - 6.2e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 EDK36508.1 - 7.9e-06 25.7 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EDK36508.1 - 0.00017 21.7 0.0 0.00028 21.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EDK36508.1 - 0.00018 21.4 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EDK36508.1 - 0.001 19.2 0.0 0.0021 18.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 EDK36508.1 - 0.001 19.5 0.0 0.0014 19.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_transf_15 PF01793.11 EDK36509.2 - 1.2e-121 405.6 13.1 1.7e-121 405.2 9.1 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase tRNA-synt_2 PF00152.15 EDK36510.2 - 5.6e-109 363.9 0.0 7.1e-109 363.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK36510.2 - 2.1e-05 24.2 0.0 8e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 EDK36510.2 - 0.00078 19.0 0.0 0.071 12.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) PADR1 PF08063.7 EDK36510.2 - 0.17 11.3 0.0 0.38 10.1 0.0 1.6 1 0 0 1 1 1 0 PADR1 (NUC008) domain PUF PF00806.14 EDK36511.2 - 1.3e-23 81.0 5.1 0.0005 19.4 0.0 8.2 10 0 0 10 10 10 5 Pumilio-family RNA binding repeat PPTA PF01239.17 EDK36512.2 - 3.8e-12 44.9 7.2 2.6e-07 29.7 0.1 3.1 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat HORMA PF02301.13 EDK36513.2 - 2.7e-43 147.8 0.4 3.1e-43 147.6 0.3 1.0 1 0 0 1 1 1 1 HORMA domain Cyclin_N PF00134.18 EDK36514.2 - 4.9e-12 45.5 0.5 1.3e-11 44.1 0.3 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain Porin_3 PF01459.17 EDK36515.1 - 3.1e-63 213.6 2.8 3.5e-63 213.4 1.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin OMP_b-brl PF13505.1 EDK36515.1 - 1.4 8.8 9.6 0.68 9.8 2.6 2.5 1 1 1 2 2 2 0 Outer membrane protein beta-barrel domain Macro_2 PF14519.1 EDK36516.2 - 7.9e-16 57.9 0.0 1.3e-15 57.3 0.0 1.3 1 1 0 1 1 1 1 Macro-like domain Macro PF01661.16 EDK36516.2 - 0.024 14.5 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Macro domain NUDIX PF00293.23 EDK36517.2 - 4.5e-15 55.4 0.0 5.6e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain BOP1NT PF08145.7 EDK36518.2 - 1.9e-107 358.8 11.4 3.7e-107 357.9 7.9 1.5 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 EDK36518.2 - 1.1e-31 107.4 6.2 3.2e-11 42.6 0.2 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat BUD22 PF09073.5 EDK36518.2 - 0.28 10.2 18.6 0.61 9.0 12.9 1.5 1 0 0 1 1 1 0 BUD22 RRM_1 PF00076.17 EDK36519.1 - 6.2e-18 64.1 0.0 1.4e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36519.1 - 3.5e-11 42.9 0.0 9.7e-11 41.4 0.0 1.8 1 1 1 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36519.1 - 1.2e-08 34.6 0.1 2.5e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Adeno_E4 PF05385.6 EDK36519.1 - 0.0033 17.3 3.4 0.88 9.5 0.0 2.4 2 0 0 2 2 2 2 Mastadenovirus early E4 13 kDa protein DUF433 PF04255.9 EDK36519.1 - 0.062 12.7 0.1 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF433) DUF2956 PF11169.3 EDK36519.1 - 4.9 7.1 8.0 8.9 6.3 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Acyltransferase PF01553.16 EDK36520.2 - 0.057 12.8 0.0 0.097 12.1 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase Histone PF00125.19 EDK36521.1 - 4.2e-26 90.8 0.0 5.4e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK36521.1 - 5.4e-05 23.1 0.0 7.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK36522.1 - 5.7e-23 80.8 0.4 8.5e-23 80.2 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK36522.1 - 1.5e-07 31.3 0.8 3.6e-07 30.1 0.1 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 EDK36522.1 - 0.0013 19.0 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.8 EDK36522.1 - 0.039 13.4 0.2 0.07 12.5 0.2 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain Herpes_glycop_H PF02489.11 EDK36522.1 - 0.053 11.5 0.9 0.053 11.5 0.6 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein H ImcF-related_N PF14331.1 EDK36522.1 - 0.086 11.7 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain tRNA_synt_1c_R2 PF04557.10 EDK36522.1 - 2.8 8.7 6.6 2.6 8.8 3.5 1.7 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 PGAP1 PF07819.8 EDK36523.2 - 7.1e-86 287.4 0.0 1.5e-85 286.3 0.0 1.5 2 0 0 2 2 2 1 PGAP1-like protein DUF676 PF05057.9 EDK36523.2 - 0.00087 18.6 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 EDK36523.2 - 0.00095 18.9 0.0 0.0019 17.9 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK36523.2 - 0.00097 19.0 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK36523.2 - 0.072 12.6 0.0 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF2974 PF11187.3 EDK36523.2 - 0.073 12.4 0.0 0.24 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) LCAT PF02450.10 EDK36523.2 - 0.1 11.5 0.0 0.57 9.0 0.0 2.0 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DUF3294 PF07957.6 EDK36525.2 - 1.6e-70 237.0 0.1 1.9e-70 236.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) DUF1104 PF06518.6 EDK36525.2 - 0.26 11.4 1.8 1.6 8.9 0.1 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF1104) Sec66 PF09802.4 EDK36526.2 - 1.8e-81 272.1 0.9 1.8e-81 272.1 0.6 1.4 2 0 0 2 2 2 1 Preprotein translocase subunit Sec66 Sec3_C PF09763.4 EDK36527.2 - 1.7e-175 585.0 32.2 1.7e-175 585.0 22.3 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 EDK36527.2 - 1.1e-16 60.4 0.0 2.8e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH BRO1 PF03097.13 EDK36528.2 - 0.0008 18.2 0.1 0.0013 17.6 0.1 1.3 1 0 0 1 1 1 1 BRO1-like domain GDA1_CD39 PF01150.12 EDK36529.1 - 3.2e-128 427.9 0.1 4.5e-128 427.4 0.1 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF1524 PF07510.6 EDK36529.1 - 0.07 12.9 0.1 0.07 12.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1524) Ppx-GppA PF02541.11 EDK36529.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family GN3L_Grn1 PF08701.6 EDK36530.2 - 2.3e-27 94.7 15.2 5e-27 93.6 10.5 1.6 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 EDK36530.2 - 3.7e-22 78.4 0.5 5e-16 58.7 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK36530.2 - 3.8e-10 39.2 0.3 2.8e-08 33.2 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EDK36530.2 - 1.4e-05 24.6 0.2 0.021 14.2 0.0 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 EDK36530.2 - 7.5e-05 21.9 0.2 0.00014 21.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EDK36530.2 - 0.00023 21.0 5.8 0.56 10.0 0.0 3.9 2 2 1 3 3 3 2 Dynamin family Miro PF08477.8 EDK36530.2 - 0.00026 21.4 0.1 0.23 11.9 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein ArgK PF03308.11 EDK36530.2 - 0.0034 16.1 0.0 0.0081 14.9 0.0 1.6 1 0 0 1 1 1 1 ArgK protein cobW PF02492.14 EDK36530.2 - 0.024 14.0 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 EDK36530.2 - 0.026 14.7 0.8 0.099 12.8 0.0 2.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EDK36530.2 - 0.048 13.9 5.7 0.049 13.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 EDK36530.2 - 0.14 12.1 1.0 0.57 10.1 0.0 2.5 2 2 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 EDK36530.2 - 0.25 12.1 0.0 0.25 12.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain CAP_GLY PF01302.20 EDK36531.2 - 5.5e-14 51.6 0.4 1.2e-13 50.5 0.3 1.6 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 EDK36531.2 - 1e-09 37.8 16.4 0.098 12.3 0.2 5.6 3 3 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK36531.2 - 2.4e-05 23.7 11.9 0.064 13.3 0.4 7.0 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.1 EDK36531.2 - 5.1e-05 22.9 11.5 0.085 12.6 0.1 4.4 1 1 3 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 EDK36531.2 - 5.4e-05 22.7 3.9 3.5 8.2 0.2 6.0 6 1 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 EDK36531.2 - 0.0076 16.2 14.8 30 5.1 1.1 6.9 4 1 3 7 7 7 0 Leucine Rich repeat PUA PF01472.15 EDK36532.1 - 4.2e-18 64.8 0.0 6.3e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 PUA domain Helicase_C PF00271.26 EDK36533.2 - 7.9e-19 67.2 0.1 1.8e-18 66.1 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecO_N_2 PF13114.1 EDK36533.2 - 0.061 13.0 0.3 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 RecO N terminal ABC_trans_N PF14510.1 EDK36534.2 - 0.13 12.3 0.0 6.6 6.8 0.0 2.6 2 0 0 2 2 2 0 ABC-transporter extracellular N-terminal DEAD PF00270.24 EDK36535.1 - 2.4e-18 66.1 0.0 3.2e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK36535.1 - 7.3e-18 65.0 0.0 1.9e-17 63.7 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EDK36535.1 - 2.8e-06 26.3 0.0 4.6e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 EDK36535.1 - 0.0031 17.6 0.0 0.0066 16.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 EDK36535.1 - 0.019 14.1 0.0 0.11 11.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein MFS_1 PF07690.11 EDK36536.2 - 7.3e-18 64.3 22.4 3.1e-17 62.3 9.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily STIL_N PF15253.1 EDK36537.2 - 0.032 12.9 1.2 0.047 12.4 0.8 1.3 1 1 0 1 1 1 0 SCL-interrupting locus protein N-terminus DUF1752 PF08550.5 EDK36537.2 - 0.07 12.7 0.2 0.07 12.7 0.1 2.3 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1752) Aa_trans PF01490.13 EDK36538.2 - 1.5e-78 264.0 38.2 1.9e-78 263.8 26.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.1 EDK36538.2 - 0.0072 14.9 41.3 0.51 8.8 28.7 2.1 1 1 0 1 1 1 1 Amino acid permease Fungal_trans PF04082.13 EDK36539.2 - 1.4e-30 106.0 2.1 2.7e-30 105.1 1.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK36539.2 - 2.1e-09 37.1 12.2 3.7e-09 36.3 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPP_enzyme_M PF00205.17 EDK36540.2 - 5.7e-30 103.8 0.0 1.5e-29 102.4 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 EDK36540.2 - 4.1e-28 98.0 0.0 6.6e-28 97.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EDK36540.2 - 5.1e-18 65.0 0.0 1.8e-17 63.3 0.0 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 EDK36540.2 - 0.02 13.8 0.0 0.062 12.2 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Alg6_Alg8 PF03155.10 EDK36541.2 - 3.1e-143 478.0 37.9 3.8e-143 477.7 26.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DEAD PF00270.24 EDK36542.1 - 1.9e-34 118.6 0.7 3.6e-34 117.6 0.5 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK36542.1 - 1.2e-23 82.7 0.0 2.2e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Flavi_DEAD PF07652.9 EDK36542.1 - 0.00015 21.5 0.1 0.00033 20.4 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_22 PF13401.1 EDK36542.1 - 0.00028 21.0 0.2 0.022 14.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Helicase_C_2 PF13307.1 EDK36542.1 - 0.023 14.6 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain DUF4258 PF14076.1 EDK36542.1 - 0.037 14.0 0.0 0.089 12.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) AAA_30 PF13604.1 EDK36542.1 - 0.093 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sod_Fe_C PF02777.13 EDK36543.2 - 9e-12 44.7 0.0 3.8e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.6 EDK36544.2 - 6e-58 195.2 4.8 6e-58 195.2 3.3 2.4 2 0 0 2 2 2 1 Pal1 cell morphology protein Mitofilin PF09731.4 EDK36544.2 - 0.58 8.7 3.7 0.66 8.5 2.6 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FYVE PF01363.16 EDK36545.2 - 1.3e-14 53.7 7.8 2.4e-14 52.9 5.4 1.4 1 0 0 1 1 1 1 FYVE zinc finger DUF1501 PF07394.7 EDK36545.2 - 0.64 8.7 2.2 0.96 8.2 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) IBR PF01485.16 EDK36545.2 - 6.8 6.6 14.3 1.7 8.6 5.9 2.5 2 1 0 2 2 2 0 IBR domain FYVE_2 PF02318.11 EDK36545.2 - 9.2 6.2 10.8 0.66 9.8 2.5 2.2 1 1 1 2 2 2 0 FYVE-type zinc finger Pmp3 PF01679.12 EDK36546.1 - 8.8e-12 44.5 1.4 9.1e-12 44.4 1.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ACOX PF01756.14 EDK36547.2 - 1.1e-45 155.3 0.0 1.8e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 EDK36547.2 - 6.9e-17 60.7 0.5 1.8e-16 59.3 0.4 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 EDK36547.2 - 1.1e-11 45.1 0.0 2.5e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 EDK36547.2 - 0.0029 17.7 0.1 0.91 9.6 0.0 2.6 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain RNA_binding PF01877.12 EDK36547.2 - 0.084 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA binding ACOX PF01756.14 EDK36548.2 - 1.4e-51 174.5 0.0 3e-51 173.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 EDK36548.2 - 8.8e-17 60.3 0.9 1.7e-16 59.4 0.6 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 EDK36548.2 - 5.7e-15 55.7 0.0 1.1e-14 54.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 EDK36548.2 - 3.5e-05 23.9 0.5 0.00087 19.4 0.4 2.6 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Pyrid_oxidase_2 PF13883.1 EDK36549.1 - 6.8e-56 188.6 0.0 7.9e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LRR_4 PF12799.2 EDK36550.2 - 2.6e-13 49.2 17.0 5.6e-06 25.8 0.3 6.3 4 1 3 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK36550.2 - 3.8e-13 48.0 10.3 0.41 10.8 0.0 8.7 9 0 0 9 9 9 4 Leucine Rich repeat LRR_8 PF13855.1 EDK36550.2 - 2.7e-08 33.4 13.3 0.004 16.8 0.1 5.6 4 1 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.28 EDK36550.2 - 2.8e-07 29.6 12.8 3.8 7.9 0.1 8.0 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_7 PF13504.1 EDK36550.2 - 6.1e-06 25.6 5.4 1.7 9.1 0.0 6.7 7 0 0 7 7 7 2 Leucine rich repeat AAA_23 PF13476.1 EDK36551.2 - 2.5e-27 96.5 0.3 2.5e-27 96.5 0.2 8.0 2 1 4 6 6 6 1 AAA domain SbcCD_C PF13558.1 EDK36551.2 - 3.5e-10 39.6 0.0 8.9e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 EDK36551.2 - 2.2e-09 36.9 22.5 1.2e-06 27.9 0.0 3.9 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK36551.2 - 0.00051 20.0 34.1 0.0027 17.7 0.1 5.1 3 3 0 4 4 4 2 AAA domain AAA_13 PF13166.1 EDK36551.2 - 0.001 17.6 0.1 0.001 17.6 0.1 7.8 2 1 5 7 7 7 4 AAA domain MscS_porin PF12795.2 EDK36551.2 - 0.0067 15.7 2.7 0.0067 15.7 1.9 9.5 3 3 6 9 9 9 1 Mechanosensitive ion channel porin domain AAA_29 PF13555.1 EDK36551.2 - 0.021 14.3 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Acyltransferase PF01553.16 EDK36552.2 - 1.4e-06 27.8 0.0 2.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase RRM_1 PF00076.17 EDK36553.2 - 1.1e-79 262.0 7.4 5.5e-17 61.1 0.1 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36553.2 - 1.8e-67 223.2 1.4 9.4e-15 54.3 0.0 5.6 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36553.2 - 2.2e-47 158.7 0.6 4.3e-11 42.4 0.0 5.6 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK36553.2 - 0.00018 21.2 0.6 3.9 7.3 0.0 4.7 6 0 0 6 6 6 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 EDK36553.2 - 0.003 17.2 1.1 3.3 7.5 0.0 4.5 4 0 0 4 4 4 1 Limkain b1 Toxin_ToxA PF11584.3 EDK36553.2 - 0.17 11.7 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA Rhomboid PF01694.17 EDK36554.2 - 9.5e-25 87.3 13.6 9.5e-25 87.3 9.4 1.6 2 0 0 2 2 2 1 Rhomboid family PTPlike_phytase PF14566.1 EDK36555.2 - 3.5 7.6 9.8 0.37 10.8 3.7 1.7 2 0 0 2 2 2 0 Inositol hexakisphosphate Sec23_trunk PF04811.10 EDK36556.2 - 8.3e-23 81.0 0.4 3.6e-16 59.2 0.0 3.0 3 0 0 3 3 3 2 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EDK36556.2 - 1.6e-14 53.1 0.1 3.2e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 EDK36556.2 - 1.9e-11 43.2 2.4 4.4e-11 42.1 1.7 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 EDK36556.2 - 5.4e-08 33.2 0.2 1.5e-07 31.7 0.1 1.8 1 1 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain DUF1749 PF08538.5 EDK36557.2 - 1.1e-100 336.4 0.0 1.3e-100 336.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 EDK36557.2 - 2.6e-09 37.3 0.0 4e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK36557.2 - 1.5e-07 31.3 0.0 2.4e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 EDK36557.2 - 9.2e-06 25.1 0.0 3.4e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) DUF2305 PF10230.4 EDK36557.2 - 0.0015 17.9 0.0 0.04 13.3 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2305) LCAT PF02450.10 EDK36557.2 - 0.022 13.7 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.8 EDK36557.2 - 0.025 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Peptidase_S9 PF00326.16 EDK36557.2 - 0.038 13.2 0.0 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.8 EDK36557.2 - 0.15 11.4 0.0 0.6 9.5 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) SAM_2 PF07647.12 EDK36558.2 - 7.6e-09 35.2 0.0 1.8e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EDK36558.2 - 5.3e-08 32.9 0.0 1.4e-07 31.5 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Ribosomal_L11_N PF03946.9 EDK36559.1 - 5.8e-18 64.1 0.2 1.3e-17 62.9 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 EDK36559.1 - 1.3e-11 44.4 0.1 2.7e-11 43.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain ACBP PF00887.14 EDK36560.2 - 1.5e-10 40.6 0.1 2.7e-10 39.7 0.1 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein DUF1320 PF07030.7 EDK36560.2 - 0.028 14.1 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) WD40 PF00400.27 EDK36561.2 - 8.3e-10 38.1 23.3 0.066 13.1 0.4 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 EDK36561.2 - 0.014 15.1 0.1 5.2 6.7 0.0 2.9 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Glyco_hydro_76 PF03663.9 EDK36562.2 - 1.2e-45 156.4 0.9 1.6e-45 156.1 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF1680 PF07944.7 EDK36562.2 - 0.0011 17.3 0.0 0.39 8.9 0.0 2.3 2 0 0 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) C5-epim_C PF06662.8 EDK36562.2 - 0.0014 17.9 0.1 0.17 11.1 0.0 2.5 2 0 0 2 2 2 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.8 EDK36562.2 - 0.0029 16.6 2.6 0.12 11.3 0.6 2.5 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 GlcNAc_2-epim PF07221.6 EDK36562.2 - 0.0049 15.9 0.0 0.039 12.9 0.0 2.2 2 1 1 3 3 3 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Sterol_MT_C PF08498.5 EDK36563.2 - 4.7e-30 103.3 0.2 6.9e-30 102.7 0.2 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 EDK36563.2 - 2.8e-17 62.9 0.0 5e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36563.2 - 4.2e-17 62.1 0.0 7.1e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK36563.2 - 4.1e-13 49.3 0.0 6.7e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EDK36563.2 - 1.1e-11 44.3 0.9 1.6e-11 43.8 0.6 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 EDK36563.2 - 2.3e-11 44.2 0.0 7.5e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36563.2 - 3.9e-11 43.3 0.0 7.7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK36563.2 - 1e-10 41.8 0.0 2.2e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36563.2 - 1.7e-08 34.4 0.0 4.4e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK36563.2 - 3.7e-06 26.2 0.0 7e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.5 EDK36563.2 - 2e-05 24.2 0.1 3.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 EDK36563.2 - 0.00023 20.5 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EDK36563.2 - 0.00037 19.7 0.0 0.00064 18.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 EDK36563.2 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 EDK36563.2 - 0.013 15.2 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 EDK36563.2 - 0.04 12.9 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Lactococcin_972 PF09683.5 EDK36563.2 - 0.042 14.2 1.5 0.12 12.6 1.1 1.8 1 0 0 1 1 1 0 Bacteriocin (Lactococcin_972) UPF0020 PF01170.13 EDK36563.2 - 0.054 13.0 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Cnd3 PF12719.2 EDK36564.2 - 2.2e-98 328.9 7.2 7.3e-98 327.2 0.9 3.8 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 EDK36564.2 - 4.7e-10 39.6 1.3 1.1e-05 25.6 0.0 5.0 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.17 EDK36564.2 - 0.0024 17.7 3.0 11 6.4 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat MIF4G PF02854.14 EDK36564.2 - 0.012 15.0 11.8 0.088 12.2 0.9 3.5 3 0 0 3 3 3 0 MIF4G domain HTH_38 PF13936.1 EDK36564.2 - 0.11 12.0 3.0 0.15 11.6 0.3 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Mak10 PF04112.8 EDK36565.2 - 2.7e-20 72.2 0.5 8.1e-20 70.7 0.1 2.0 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PAP1 PF08601.5 EDK36566.2 - 1.1e-36 127.2 36.8 2.7e-32 112.8 6.6 4.4 1 1 2 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.16 EDK36566.2 - 1.3e-10 41.0 8.3 2.3e-10 40.2 5.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EDK36566.2 - 7.6e-06 25.6 10.4 2.5e-05 23.9 7.2 1.9 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EDK36566.2 - 0.00064 19.9 7.1 0.0011 19.1 4.9 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor MscS_porin PF12795.2 EDK36566.2 - 0.002 17.5 2.9 0.003 16.8 2.0 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain CCDC155 PF14662.1 EDK36566.2 - 0.055 13.0 3.5 0.089 12.3 2.4 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 dsrm PF00035.20 EDK36566.2 - 0.072 13.6 0.1 0.26 11.8 0.0 1.9 2 0 0 2 2 2 0 Double-stranded RNA binding motif RILP PF11461.3 EDK36566.2 - 0.088 12.9 0.1 0.088 12.9 0.0 2.0 2 0 0 2 2 2 0 Rab interacting lysosomal protein Adeno_PIX PF03955.9 EDK36566.2 - 0.12 12.8 0.5 0.36 11.3 0.4 1.7 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) DivIC PF04977.10 EDK36566.2 - 0.6 9.6 2.6 1.1 8.8 1.8 1.4 1 0 0 1 1 1 0 Septum formation initiator NDUFA12 PF05071.11 EDK36567.1 - 1e-26 93.4 3.7 1.3e-26 93.1 2.5 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DS PF01916.12 EDK36568.2 - 1.1e-142 474.5 0.0 1.3e-142 474.3 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Peptidase_M18 PF02127.10 EDK36569.2 - 2.6e-141 471.0 0.0 3e-141 470.8 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 EDK36569.2 - 0.00057 18.7 0.1 0.028 13.2 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase LRR19-TM PF15176.1 EDK36569.2 - 0.14 11.8 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain G-alpha PF00503.15 EDK36571.2 - 9.3e-120 399.8 3.0 1.1e-119 399.6 2.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 EDK36571.2 - 8.4e-15 54.4 0.7 1.5e-09 37.3 0.1 3.0 3 1 0 3 3 3 2 ADP-ribosylation factor family Miro PF08477.8 EDK36571.2 - 0.016 15.7 0.1 1.5 9.3 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 EDK36571.2 - 0.06 12.8 0.2 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.7 EDK36571.2 - 0.094 11.8 3.9 3.2 6.8 0.0 2.6 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Pkinase PF00069.20 EDK36572.2 - 5.1e-72 242.1 0.0 7e-72 241.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36572.2 - 3e-33 115.0 0.0 7.1e-33 113.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36572.2 - 0.00024 20.1 0.0 0.0089 15.0 0.0 2.1 2 0 0 2 2 2 2 Kinase-like SIS PF01380.17 EDK36573.2 - 6.3e-64 213.4 0.1 5.6e-34 116.5 0.1 2.3 2 0 0 2 2 2 2 SIS domain SIS_2 PF13580.1 EDK36573.2 - 0.00044 19.9 0.0 0.025 14.2 0.0 2.4 2 0 0 2 2 2 2 SIS domain DUF155 PF02582.9 EDK36574.2 - 4.5e-41 140.6 0.0 6.1e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Candida_ALS_N PF11766.3 EDK36575.2 - 5.8e-78 261.2 0.9 5.8e-78 261.2 0.6 2.3 2 1 1 3 3 3 1 Cell-wall agglutinin N-terminal ligand-sugar binding Candida_ALS PF05792.8 EDK36575.2 - 0.00022 21.2 16.2 0.00022 21.2 11.2 9.5 11 2 0 11 11 11 4 Candida agglutinin-like (ALS) DBB PF14545.1 EDK36575.2 - 0.01 15.3 2.9 2.7 7.4 0.2 3.4 2 1 1 3 3 3 0 Dof, BCAP, and BANK (DBB) motif, Ammonium_transp PF00909.16 EDK36576.2 - 3e-106 355.2 27.4 3.6e-106 355.0 19.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Aminotran_5 PF00266.14 EDK36577.2 - 1.5e-27 96.3 0.0 2.1e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V SLA_LP_auto_ag PF05889.8 EDK36577.2 - 0.0027 16.2 0.0 0.0042 15.6 0.0 1.3 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Aminotran_1_2 PF00155.16 EDK36577.2 - 0.012 14.5 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EDK36577.2 - 0.024 12.9 0.1 0.038 12.2 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EDK36577.2 - 0.12 11.3 0.1 0.36 9.8 0.1 1.7 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TPP_enzyme_N PF02776.13 EDK36578.2 - 2.2e-56 190.0 0.0 5.4e-56 188.7 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EDK36578.2 - 5.2e-49 165.7 1.6 2.7e-47 160.1 0.2 3.7 5 0 0 5 5 5 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EDK36578.2 - 8.2e-36 122.7 1.0 1.7e-35 121.7 0.3 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Zn_clus PF00172.13 EDK36579.2 - 4.3e-10 39.3 11.1 6.8e-10 38.6 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFCD_C PF12612.3 EDK36580.2 - 0.00059 19.3 8.8 0.093 12.1 0.0 4.1 4 0 0 4 4 4 3 Tubulin folding cofactor D C terminal HEAT PF02985.17 EDK36580.2 - 0.0045 16.9 0.5 0.42 10.8 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat FliD_C PF07195.7 EDK36580.2 - 0.032 13.5 0.1 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DUF1546 PF07571.8 EDK36580.2 - 0.26 11.4 3.3 8.9 6.4 0.1 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1546) Ribosomal_L30 PF00327.15 EDK36581.1 - 2.9e-14 52.3 0.9 4.5e-14 51.7 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e MNE1 PF13762.1 EDK36582.2 - 1.6e-50 170.9 7.2 1.6e-50 170.9 5.0 3.4 3 1 0 3 3 3 2 Mitochondrial splicing apparatus component Arv1 PF04161.8 EDK36582.2 - 0.9 9.4 8.6 0.029 14.2 0.8 2.2 3 0 0 3 3 3 0 Arv1-like family Methyltransf_23 PF13489.1 EDK36583.2 - 1.8e-15 57.0 0.0 2.9e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36583.2 - 4.8e-11 43.0 0.0 1.3e-10 41.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36583.2 - 4.5e-09 36.0 0.5 1.6e-08 34.2 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36583.2 - 9.8e-09 35.6 0.0 4e-08 33.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK36583.2 - 0.00023 21.4 0.0 0.00047 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36583.2 - 0.0045 17.0 0.0 0.015 15.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36583.2 - 0.037 14.5 0.1 0.21 12.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.14 EDK36583.2 - 0.05 13.5 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 EDK36583.2 - 0.076 12.1 0.0 0.48 9.4 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Lon_C PF05362.8 EDK36584.2 - 2.4e-47 160.9 0.1 4.1e-47 160.1 0.1 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 EDK36584.2 - 3.7e-45 154.1 2.1 8.6e-45 152.9 0.1 2.3 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain AAA PF00004.24 EDK36584.2 - 8.6e-26 90.6 0.0 1.1e-24 87.1 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EDK36584.2 - 5.2e-07 29.4 0.0 3.1e-06 26.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 EDK36584.2 - 7.6e-07 28.6 0.1 1.5e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.9 EDK36584.2 - 2e-06 27.8 0.0 5.7e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 EDK36584.2 - 7.9e-06 25.7 0.1 0.0041 17.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EDK36584.2 - 2.3e-05 24.5 0.3 0.012 15.7 0.0 3.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK36584.2 - 4.4e-05 23.5 0.0 0.00017 21.6 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK36584.2 - 0.0001 23.0 0.3 0.00079 20.2 0.0 2.8 3 0 0 3 3 1 1 AAA domain AAA_19 PF13245.1 EDK36584.2 - 0.00016 21.3 0.0 0.00035 20.2 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EDK36584.2 - 0.00024 20.2 0.0 0.0011 18.1 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 EDK36584.2 - 0.00067 18.4 0.2 0.0054 15.5 0.0 2.1 2 0 0 2 2 2 1 TIP49 C-terminus Zeta_toxin PF06414.7 EDK36584.2 - 0.0014 17.7 0.1 0.0027 16.8 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 EDK36584.2 - 0.0015 18.1 0.0 0.003 17.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EDK36584.2 - 0.0032 17.3 0.0 0.0068 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EDK36584.2 - 0.0048 16.3 0.3 0.019 14.4 0.0 2.1 2 1 0 2 2 2 1 AAA-like domain Mg_chelatase PF01078.16 EDK36584.2 - 0.0068 15.5 0.0 0.071 12.2 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI UPF0079 PF02367.12 EDK36584.2 - 0.0078 15.8 0.0 0.039 13.5 0.0 2.0 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 NB-ARC PF00931.17 EDK36584.2 - 0.0092 14.8 1.1 0.013 14.3 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain PhoH PF02562.11 EDK36584.2 - 0.012 14.8 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.12 EDK36584.2 - 0.019 14.3 0.0 0.043 13.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 EDK36584.2 - 0.019 15.2 3.0 0.032 14.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 EDK36584.2 - 0.028 14.5 1.0 0.1 12.8 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.1 EDK36584.2 - 0.031 13.6 0.1 0.094 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain NACHT PF05729.7 EDK36584.2 - 0.032 13.9 0.0 0.11 12.1 0.0 2.0 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 EDK36584.2 - 0.046 13.4 0.1 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 EDK36584.2 - 0.057 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 EDK36584.2 - 0.081 12.6 0.1 0.29 10.8 0.0 2.0 1 1 1 2 2 2 0 NTPase TRP_N PF14558.1 EDK36585.2 - 4.9e-45 153.0 1.0 8.4e-45 152.2 0.7 1.4 1 0 0 1 1 1 1 ML-like domain TRP PF06011.7 EDK36585.2 - 4.6e-36 124.3 5.6 4.6e-36 124.3 3.9 1.5 2 0 0 2 2 2 1 Transient receptor potential (TRP) ion channel TRP PF06011.7 EDK36586.2 - 4.6e-43 147.4 11.7 4.8e-43 147.3 8.1 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF3611 PF12263.3 EDK36586.2 - 0.0064 15.9 0.2 0.014 14.7 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) DUF2273 PF10031.4 EDK36586.2 - 0.21 11.2 7.2 6.5 6.4 0.2 3.1 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) OppC_N PF12911.2 EDK36586.2 - 0.23 10.8 5.5 2.1 7.8 0.2 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C RhodobacterPufX PF11511.3 EDK36586.2 - 0.33 10.3 1.9 0.8 9.1 1.3 1.6 1 0 0 1 1 1 0 Intrinsic membrane protein PufX DUF202 PF02656.10 EDK36586.2 - 3.4 7.9 7.3 0.19 11.9 0.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF663 PF04950.7 EDK36588.2 - 1.3e-95 319.8 0.0 1.3e-95 319.8 0.0 3.0 4 0 0 4 4 2 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EDK36588.2 - 6.5e-30 102.5 0.0 5.5e-28 96.3 0.0 2.8 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 EDK36588.2 - 7.1e-08 32.1 0.0 2e-05 24.0 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 EDK36588.2 - 1.7e-06 27.9 1.8 2.4e-06 27.5 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA PF00004.24 EDK36588.2 - 9e-06 25.9 0.5 2.4e-05 24.5 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK36588.2 - 2e-05 24.7 0.1 8e-05 22.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EDK36588.2 - 2.9e-05 23.7 0.4 0.0001 22.0 0.3 1.9 1 0 0 1 1 1 1 Part of AAA domain MobB PF03205.9 EDK36588.2 - 3.1e-05 23.6 0.6 0.00012 21.8 0.2 2.1 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EDK36588.2 - 6e-05 23.1 0.0 0.00017 21.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK36588.2 - 0.00029 21.6 0.0 0.00029 21.6 0.0 4.4 3 1 1 4 4 2 1 AAA domain Miro PF08477.8 EDK36588.2 - 0.00087 19.7 0.0 0.0037 17.7 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein RNA_helicase PF00910.17 EDK36588.2 - 0.0012 19.0 0.0 0.0038 17.3 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.1 EDK36588.2 - 0.0013 18.7 0.1 0.0051 16.7 0.1 2.1 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 EDK36588.2 - 0.0013 18.4 0.5 0.0036 17.0 0.4 1.7 1 0 0 1 1 1 1 NTPase NACHT PF05729.7 EDK36588.2 - 0.0025 17.4 0.1 0.0053 16.4 0.1 1.6 1 1 0 1 1 1 1 NACHT domain ABC_tran PF00005.22 EDK36588.2 - 0.0033 17.7 2.1 0.0064 16.7 0.0 2.6 2 0 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.18 EDK36588.2 - 0.0048 16.8 0.5 0.019 14.9 0.3 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 EDK36588.2 - 0.0048 16.3 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 EDK36588.2 - 0.0076 15.6 0.0 0.025 13.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EDK36588.2 - 0.0093 15.6 0.1 0.023 14.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 EDK36588.2 - 0.013 15.1 0.4 0.013 15.1 0.3 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EDK36588.2 - 0.013 15.8 0.1 0.013 15.8 0.0 4.6 4 2 0 4 4 1 0 AAA domain cobW PF02492.14 EDK36588.2 - 0.017 14.5 0.4 0.037 13.4 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.1 EDK36588.2 - 0.018 14.6 0.0 0.018 14.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain Cyclin PF08613.6 EDK36589.2 - 5.2e-20 72.3 1.3 8.3e-20 71.7 0.9 1.4 1 0 0 1 1 1 1 Cyclin Ribonuclease_3 PF00636.21 EDK36590.2 - 0.0057 17.0 0.0 0.024 15.0 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease III domain Cytokin_check_N PF10407.4 EDK36591.2 - 4.1e-28 96.8 0.0 7.4e-28 95.9 0.0 1.4 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus DUF596 PF04591.7 EDK36591.2 - 0.11 12.3 0.0 25 4.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF596 tRNA-synt_2b PF00587.20 EDK36592.2 - 9.5e-36 122.9 0.1 2.2e-35 121.7 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EDK36592.2 - 1.5e-22 79.6 7.7 1.5e-22 79.6 5.4 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.7 EDK36592.2 - 2.7 8.3 5.2 2.1 8.6 2.0 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.6 EDK36592.2 - 6.8 6.6 6.0 24 4.8 1.4 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.27 EDK36593.2 - 1.6e-31 107.0 11.8 2.9e-08 33.2 0.1 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat adh_short_C2 PF13561.1 EDK36594.2 - 5.3e-22 78.7 0.0 6.2e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK36594.2 - 1.4e-18 67.4 0.0 1.7e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK36594.2 - 1.1e-10 41.4 0.0 4.4e-10 39.5 0.0 1.7 2 0 0 2 2 2 1 KR domain LsmAD PF06741.8 EDK36594.2 - 0.13 12.4 0.3 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 LsmAD domain NUFIP1 PF10453.4 EDK36595.2 - 2.2e-18 65.4 4.4 2.2e-18 65.4 3.0 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.19 EDK36595.2 - 2.4e-05 23.8 3.4 3.8e-05 23.2 2.3 1.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) APC_CDC26 PF10471.4 EDK36595.2 - 0.025 15.2 2.1 0.025 15.2 1.5 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 DUF2508 PF10704.4 EDK36595.2 - 0.096 12.8 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) zf-CCCH_2 PF14608.1 EDK36595.2 - 3.4 7.7 6.5 0.63 10.1 1.3 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type FA_desaturase PF00487.19 EDK36596.2 - 4.6e-38 131.1 24.0 6.3e-38 130.6 16.6 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 EDK36596.2 - 7.7e-15 54.4 0.0 1.6e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFIIB PF00382.14 EDK36597.2 - 1.4e-42 143.3 0.7 1.9e-20 72.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 EDK36597.2 - 3.2e-13 48.7 1.2 5.8e-13 47.9 0.8 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Chordopox_RPO7 PF05864.7 EDK36597.2 - 0.33 11.0 3.5 58 3.8 0.0 3.8 3 1 1 4 4 4 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Mcp5_PH PF12814.2 EDK36598.2 - 8.5e-41 138.7 0.0 4e-40 136.5 0.0 2.3 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF3301 PF11743.3 EDK36598.2 - 0.2 11.2 1.4 32 4.1 0.0 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF3301) Reo_sigmaC PF04582.7 EDK36598.2 - 1.1 8.3 26.3 2.7 7.0 3.1 4.5 3 0 0 3 3 3 0 Reovirus sigma C capsid protein DUF3533 PF12051.3 EDK36599.2 - 6.3e-138 459.6 19.6 7.5e-138 459.4 13.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) HXXSHH PF07586.6 EDK36599.2 - 0.019 13.9 3.2 0.37 9.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) DUF4234 PF14018.1 EDK36599.2 - 0.096 12.4 0.1 0.096 12.4 0.0 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) PMT PF02366.13 EDK36600.2 - 3.1e-79 265.8 25.1 3.1e-79 265.8 17.4 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EDK36600.2 - 5.6e-27 94.5 0.2 8.8e-27 93.8 0.2 1.3 1 0 0 1 1 1 1 MIR domain SNURF PF07192.6 EDK36600.2 - 0.18 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 SNURF/RPN4 protein DUF202 PF02656.10 EDK36600.2 - 2.4 8.4 6.0 0.7 10.1 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF202) CBFD_NFYB_HMF PF00808.18 EDK36601.2 - 2e-19 69.4 0.9 2e-19 69.4 0.6 2.3 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK36601.2 - 9.7e-13 48.0 0.0 1.9e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 EDK36601.2 - 0.013 15.3 0.1 0.013 15.3 0.1 2.0 2 0 0 2 2 2 0 CENP-S associating Centromere protein X SPOB_a PF14689.1 EDK36601.2 - 0.3 10.6 2.2 0.76 9.3 1.5 1.7 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain PBP PF01161.15 EDK36602.2 - 1.3e-31 109.4 0.1 1.6e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DIM1 PF02966.11 EDK36604.1 - 1.4e-69 231.7 0.1 1.7e-69 231.4 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Amidohydro_4 PF13147.1 EDK36605.2 - 7.7e-07 29.4 0.0 1.2e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 EDK36605.2 - 3.7e-06 26.7 0.1 1.2e-05 24.9 0.0 1.9 3 0 0 3 3 3 1 Amidohydrolase Amidohydro_1 PF01979.15 EDK36605.2 - 0.1 12.2 1.2 7 6.1 0.1 2.5 1 1 1 2 2 2 0 Amidohydrolase family Sugar_tr PF00083.19 EDK36606.2 - 7.8e-28 97.2 32.0 2e-18 66.2 8.5 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 EDK36606.2 - 2.3e-14 52.8 43.7 2.8e-08 32.8 19.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 EDK36606.2 - 0.12 10.8 24.9 0.043 12.3 3.4 3.3 2 2 1 3 3 3 0 Vacuole effluxer Atg22 like AA_permease PF00324.16 EDK36608.2 - 8.7e-78 261.7 46.0 1.8e-77 260.6 31.9 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK36608.2 - 9.4e-31 106.7 39.5 1.6e-30 105.9 27.3 1.4 1 1 0 1 1 1 1 Amino acid permease Ribophorin_II PF05817.9 EDK36609.2 - 0.072 11.2 0.4 0.11 10.7 0.3 1.2 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Ded_cyto PF06920.8 EDK36612.2 - 9.6e-24 83.6 0.1 1.6e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Dedicator of cytokinesis TPR_11 PF13414.1 EDK36612.2 - 0.82 9.3 3.0 0.54 9.9 0.4 1.9 2 0 0 2 2 2 0 TPR repeat PP-binding PF00550.20 EDK36613.1 - 3.4e-11 43.2 1.2 5.1e-11 42.6 0.8 1.3 1 1 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 EDK36613.1 - 4e-06 26.7 0.9 8.7e-06 25.6 0.3 1.6 1 1 1 2 2 2 1 Acyl-carrier DUF1493 PF07377.7 EDK36613.1 - 0.06 13.4 0.2 0.087 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) LRR_4 PF12799.2 EDK36614.1 - 6.6e-53 175.6 68.7 9.2e-11 41.1 0.5 7.2 3 1 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK36614.1 - 6.6e-22 77.0 50.9 4.6e-08 32.6 4.1 6.0 3 2 4 7 7 7 5 Leucine rich repeat LRR_6 PF13516.1 EDK36614.1 - 2.5e-13 48.5 30.1 0.14 12.3 0.2 10.6 6 2 3 9 9 9 5 Leucine Rich repeat LRR_9 PF14580.1 EDK36614.1 - 1.4e-11 44.2 15.8 3.8e-09 36.3 2.1 3.2 1 1 2 3 3 3 2 Leucine-rich repeat LRR_7 PF13504.1 EDK36614.1 - 1.2e-10 39.7 24.8 3 8.4 0.0 10.3 10 1 0 10 10 10 5 Leucine rich repeat LRR_1 PF00560.28 EDK36614.1 - 4.6e-10 38.1 44.8 0.18 11.9 0.6 10.8 10 2 1 11 11 11 5 Leucine Rich Repeat UB2H PF14814.1 EDK36614.1 - 0.26 11.0 5.1 35 4.1 0.0 4.6 2 2 3 5 5 5 0 Bifunctional transglycosylase second domain LRR_2 PF07723.8 EDK36614.1 - 0.7 10.4 3.1 50 4.6 0.1 4.2 5 0 0 5 5 5 0 Leucine Rich Repeat DUF3744 PF12558.3 EDK36614.1 - 8.7 6.8 18.7 2.1 8.8 0.9 4.6 2 1 2 4 4 4 0 ATP-binding cassette cobalt transporter IF-2B PF01008.12 EDK36615.2 - 2.1e-40 138.4 2.1 4e-40 137.5 1.5 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Med1 PF10744.4 EDK36616.2 - 1e-56 192.3 0.6 1.6e-56 191.7 0.4 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 CIA30 PF08547.7 EDK36616.2 - 0.091 12.6 0.0 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Complex I intermediate-associated protein 30 (CIA30) Ubie_methyltran PF01209.13 EDK36617.2 - 1.1e-87 293.0 0.1 1.3e-87 292.8 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 EDK36617.2 - 5e-10 39.7 0.0 8.1e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36617.2 - 6.6e-10 38.7 0.0 1.3e-09 37.7 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36617.2 - 2.5e-08 34.2 0.0 5.8e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK36617.2 - 1.3e-06 28.7 0.0 2.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK36617.2 - 1.7e-05 24.5 0.0 2.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36617.2 - 0.00011 22.7 0.0 0.00022 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36617.2 - 0.0026 17.7 0.0 0.0084 16.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EDK36617.2 - 0.12 11.9 0.0 0.52 9.9 0.0 2.0 3 0 0 3 3 3 0 Hypothetical methyltransferase PK PF00224.16 EDK36618.1 - 4.1e-167 555.1 3.1 5.4e-167 554.7 2.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 EDK36618.1 - 8.5e-33 112.3 0.1 2.4e-32 110.9 0.1 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 EDK36618.1 - 0.00033 19.6 0.4 0.00077 18.4 0.1 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DnaJ PF00226.26 EDK36619.2 - 7.8e-09 35.1 0.6 1.6e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain Pam16 PF03656.8 EDK36619.2 - 0.011 15.4 0.0 0.026 14.3 0.0 1.6 2 0 0 2 2 2 0 Pam16 AAA PF00004.24 EDK36620.2 - 9.7e-57 190.8 0.0 5.7e-43 146.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EDK36620.2 - 3.2e-05 24.7 0.1 0.0014 19.4 0.0 3.1 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 EDK36620.2 - 4.8e-05 22.5 0.0 0.0016 17.5 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 EDK36620.2 - 0.00012 21.5 0.1 0.0022 17.4 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK36620.2 - 0.00013 21.9 0.4 0.029 14.3 0.0 3.4 2 1 1 3 3 3 1 AAA ATPase domain Parvo_NS1 PF01057.12 EDK36620.2 - 0.00024 20.0 0.0 0.00047 19.1 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_14 PF13173.1 EDK36620.2 - 0.00052 19.9 0.0 0.11 12.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EDK36620.2 - 0.00068 19.7 0.0 0.0072 16.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EDK36620.2 - 0.00091 18.6 0.0 0.0021 17.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.17 EDK36620.2 - 0.0016 18.5 0.0 0.016 15.3 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.9 EDK36620.2 - 0.0017 18.2 0.0 0.0063 16.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 EDK36620.2 - 0.0038 16.9 0.1 0.039 13.6 0.0 2.8 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EDK36620.2 - 0.0089 14.7 0.0 0.023 13.4 0.0 1.6 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 EDK36620.2 - 0.01 15.5 0.0 0.028 14.1 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_33 PF13671.1 EDK36620.2 - 0.012 15.5 0.0 0.27 11.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EDK36620.2 - 0.012 15.9 0.0 0.091 13.0 0.0 2.6 2 0 0 2 2 1 0 AAA domain KaiC PF06745.8 EDK36620.2 - 0.014 14.4 0.1 0.044 12.9 0.0 1.8 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.16 EDK36620.2 - 0.016 14.3 0.0 0.034 13.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 EDK36620.2 - 0.026 14.5 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EDK36620.2 - 0.041 13.4 0.1 0.18 11.3 0.1 2.2 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EDK36620.2 - 0.057 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.7 EDK36620.2 - 0.11 12.1 0.1 2.3 7.8 0.0 2.9 3 0 0 3 3 3 0 NACHT domain Ribosomal_L31e PF01198.14 EDK36621.1 - 3.4e-17 61.8 0.4 4.3e-17 61.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Chorismate_bind PF00425.13 EDK36623.2 - 0.001 18.4 0.5 0.0014 18.0 0.3 1.2 1 0 0 1 1 1 1 chorismate binding enzyme DUF3091 PF11291.3 EDK36623.2 - 0.15 12.0 2.2 0.14 12.1 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) GlnD_UR_UTase PF08335.6 EDK36623.2 - 0.19 11.5 3.7 1.4 8.7 0.5 2.0 1 1 1 2 2 2 0 GlnD PII-uridylyltransferase DUF3412 PF11892.3 EDK36623.2 - 0.34 10.7 2.5 2.6 7.8 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3412) DUF4094 PF13334.1 EDK36623.2 - 1.7 9.0 9.9 2.3 8.6 0.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) MobC PF05713.6 EDK36623.2 - 3.2 7.7 7.8 5.3 7.0 0.2 3.1 2 1 1 3 3 3 0 Bacterial mobilisation protein (MobC) DUF4050 PF13259.1 EDK36624.2 - 1.9e-18 66.5 0.7 1.9e-18 66.5 0.5 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF4050) Rxt3 PF08642.5 EDK36625.2 - 6.9e-24 84.3 0.0 6.9e-24 84.3 0.0 2.9 3 2 0 3 3 3 1 Histone deacetylation protein Rxt3 Innate_immun PF12782.2 EDK36625.2 - 1.1 8.4 11.8 1.6 7.8 8.2 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family CPSF73-100_C PF11718.3 EDK36625.2 - 7.5 5.8 7.8 13 5.0 5.4 1.3 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Vps39_1 PF10366.4 EDK36626.2 - 1.5e-33 115.0 0.5 1.5e-33 115.0 0.3 2.8 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 EDK36626.2 - 1.5e-20 73.3 0.6 4.6e-20 71.8 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.17 EDK36626.2 - 1.2e-10 41.2 1.3 1.7e-10 40.8 0.2 1.7 2 0 0 2 2 2 1 CNH domain Utp21 PF04192.7 EDK36627.2 - 1.4e-80 269.8 1.9 2e-80 269.3 1.3 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 EDK36627.2 - 5.2e-21 73.6 5.7 1.8e-09 37.0 0.0 9.2 10 1 0 10 10 10 3 WD domain, G-beta repeat PQQ_2 PF13360.1 EDK36627.2 - 1.8e-05 24.3 0.0 0.00075 19.0 0.0 3.1 3 1 0 3 3 3 1 PQQ-like domain eIF2A PF08662.6 EDK36627.2 - 0.00012 21.9 0.0 0.079 12.6 0.0 2.9 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 EDK36627.2 - 0.0099 14.2 0.0 0.021 13.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome D1 heme domain BBS2_N PF14781.1 EDK36627.2 - 0.013 15.0 0.1 0.098 12.2 0.0 2.4 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal Apc4_WD40 PF12894.2 EDK36627.2 - 0.04 13.4 0.0 11 5.6 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Dus PF01207.12 EDK36628.2 - 2.5e-46 157.9 0.0 4.1e-45 153.9 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 EDK36628.2 - 0.11 12.1 1.7 0.93 9.2 0.1 2.3 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Bap31 PF05529.7 EDK36629.1 - 5.1e-59 198.9 1.7 1.1e-58 197.8 1.2 1.5 1 1 0 1 1 1 1 B-cell receptor-associated protein 31-like Mod_r PF07200.8 EDK36629.1 - 0.025 14.4 0.4 0.045 13.6 0.2 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF3847 PF12958.2 EDK36629.1 - 0.097 12.4 0.9 0.15 11.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Mem_trans PF03547.13 EDK36630.2 - 2.8e-51 174.0 0.1 3.5e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Membrane transport protein TOM_sub5 PF15178.1 EDK36630.2 - 0.092 12.4 0.0 0.26 10.9 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM5 homolog Ashwin PF15323.1 EDK36630.2 - 0.27 11.2 9.6 0.39 10.6 6.6 1.2 1 0 0 1 1 1 0 Developmental protein Ebola_NP PF05505.7 EDK36630.2 - 3.3 5.6 7.0 4.5 5.2 4.8 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein SSrecog PF03531.9 EDK36631.2 - 4.9e-78 261.4 0.2 1e-77 260.4 0.1 1.6 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 EDK36631.2 - 1.1e-30 105.4 0.0 7.6e-29 99.5 0.0 3.2 3 1 0 3 3 3 1 Histone chaperone Rttp106-like bPH_2 PF03703.9 EDK36631.2 - 0.1 12.6 0.0 2.4 8.2 0.0 2.9 3 0 0 3 3 3 0 Bacterial PH domain Semialdhyde_dhC PF02774.13 EDK36632.2 - 2.5e-40 138.3 0.0 3.7e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 EDK36632.2 - 9.3e-34 116.3 0.0 1.6e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 EDK36632.2 - 0.0011 19.4 0.0 0.0028 18.1 0.0 1.7 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Saccharop_dh PF03435.13 EDK36632.2 - 0.0023 16.9 0.4 0.0057 15.6 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase DapB_N PF01113.15 EDK36632.2 - 0.0024 17.7 0.0 0.0056 16.5 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Methyltransf_16 PF10294.4 EDK36633.2 - 3e-08 33.3 0.0 1.2e-06 28.1 0.0 2.2 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EDK36633.2 - 0.029 14.9 0.0 0.048 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 EDK36633.2 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.1 EDK36633.2 - 0.14 11.7 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 EDK36633.2 - 0.17 11.4 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SAC3_GANP PF03399.11 EDK36634.2 - 2.6e-69 232.8 0.2 2.6e-69 232.8 0.1 2.9 3 0 0 3 3 3 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SAC3 PF12209.3 EDK36634.2 - 6.1e-27 93.5 2.5 6.1e-27 93.5 1.8 2.2 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain DUF445 PF04286.7 EDK36634.2 - 0.14 11.6 10.2 0.037 13.5 1.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF445) Sybindin PF04099.7 EDK36635.2 - 1.7e-16 60.2 0.2 2e-16 60.0 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family ENTH PF01417.15 EDK36636.2 - 3.5e-45 152.8 0.1 6e-45 152.1 0.1 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 EDK36636.2 - 0.00075 18.2 0.0 0.001 17.8 0.0 1.2 1 0 0 1 1 1 1 ANTH domain DSS1_SEM1 PF05160.8 EDK36636.2 - 0.0072 16.0 0.5 2.8 7.7 0.1 3.3 3 0 0 3 3 3 1 DSS1/SEM1 family VHS PF00790.14 EDK36636.2 - 0.11 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 VHS domain VirionAssem_T7 PF11653.3 EDK36636.2 - 5.2 7.8 8.4 1 10.1 0.2 3.2 4 0 0 4 4 4 0 Bacteriophage T7 virion assembly protein Pro_isomerase PF00160.16 EDK36637.1 - 1.1e-47 162.1 0.1 1.4e-47 161.7 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CCDC84 PF14968.1 EDK36639.2 - 8e-06 25.5 0.3 8e-06 25.5 0.2 1.5 1 1 0 1 1 1 1 Coiled coil protein 84 zf-met PF12874.2 EDK36639.2 - 0.0074 16.4 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF4404 PF14357.1 EDK36639.2 - 0.027 14.8 3.1 0.07 13.5 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) zf-C2H2_jaz PF12171.3 EDK36639.2 - 0.036 14.2 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF1800 PF08811.6 EDK36639.2 - 0.36 9.7 3.8 0.62 8.9 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) DUF1168 PF06658.7 EDK36639.2 - 1.5 8.3 20.0 0.1 12.1 7.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) PNK3P PF08645.6 EDK36640.2 - 1.2e-53 180.7 0.7 1.8e-53 180.2 0.5 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Hydrolase_3 PF08282.7 EDK36640.2 - 0.17 11.4 1.9 0.85 9.1 1.3 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ADK PF00406.17 EDK36641.2 - 0.016 15.0 0.8 0.18 11.6 0.2 2.6 1 1 2 3 3 3 0 Adenylate kinase Ribosomal_S8 PF00410.14 EDK36642.2 - 9e-20 70.8 0.0 1.2e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 DUF4201 PF13870.1 EDK36644.2 - 0.00032 20.2 0.5 0.00032 20.2 0.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) TMF_DNA_bd PF12329.3 EDK36644.2 - 0.0012 18.6 3.2 0.0012 18.6 2.2 2.8 3 0 0 3 3 2 1 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 EDK36644.2 - 0.0092 15.4 1.8 0.0092 15.4 1.2 2.6 2 0 0 2 2 2 1 Septum formation initiator Pox_A_type_inc PF04508.7 EDK36644.2 - 0.022 14.5 7.2 0.4 10.5 0.0 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.7 EDK36644.2 - 0.022 13.9 1.4 0.026 13.7 1.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein SlyX PF04102.7 EDK36644.2 - 0.12 12.7 2.2 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 SlyX Tmemb_cc2 PF10267.4 EDK36644.2 - 1.3 7.5 15.1 3.8 6.0 10.4 1.7 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ATG16 PF08614.6 EDK36644.2 - 1.7 8.4 19.4 9.9 5.9 13.5 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Herpes_UL6 PF01763.11 EDK36644.2 - 4.3 5.3 10.1 0.056 11.6 0.8 1.9 1 1 1 2 2 2 0 Herpesvirus UL6 like GAS PF13851.1 EDK36644.2 - 4.4 6.4 18.5 0.18 11.0 2.8 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.6 EDK36644.2 - 9.4 6.2 9.9 0.88 9.5 0.1 3.3 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Zip PF02535.17 EDK36645.2 - 6.8e-62 209.2 1.2 7.8e-62 209.0 0.8 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Sporozoite_P67 PF05642.6 EDK36645.2 - 0.11 10.3 1.7 0.15 9.8 1.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CBS PF00571.23 EDK36646.1 - 8.8e-29 99.0 4.9 1.2e-12 47.4 0.2 4.9 4 1 1 5 5 5 4 CBS domain Gly_transf_sug PF04488.10 EDK36646.1 - 0.0076 16.6 0.7 0.073 13.4 0.2 2.7 2 1 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif OPT PF03169.10 EDK36647.2 - 7.7e-146 487.0 34.6 8.8e-146 486.8 24.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein KH_1 PF00013.24 EDK36648.2 - 1.3e-35 120.8 5.9 2.7e-13 49.3 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EDK36648.2 - 1e-27 95.2 7.1 3.2e-09 36.2 0.4 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 EDK36648.2 - 1.3e-11 43.9 4.4 0.0029 17.1 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EDK36648.2 - 2.5e-06 27.0 0.7 0.59 9.8 0.1 3.9 4 1 0 4 4 4 3 KH domain KH_5 PF13184.1 EDK36648.2 - 0.004 16.9 5.2 4.8 7.0 0.2 3.4 3 0 0 3 3 3 2 NusA-like KH domain BCNT PF07572.7 EDK36649.2 - 9.3e-27 92.7 4.5 2.9e-26 91.2 3.1 1.9 1 0 0 1 1 1 1 Bucentaur or craniofacial development Peptidase_M49 PF03571.10 EDK36650.2 - 2.3e-234 778.5 0.0 2.9e-234 778.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 DUF3910 PF13049.1 EDK36650.2 - 0.0096 15.9 0.1 0.024 14.7 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3910) ABC_membrane PF00664.18 EDK36651.2 - 1e-44 153.0 6.9 1.6e-44 152.3 4.7 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EDK36651.2 - 8.1e-29 100.6 0.3 5.5e-28 97.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.14 EDK36651.2 - 5.6e-07 29.0 0.0 1e-06 28.1 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 EDK36651.2 - 5.6e-05 21.9 0.3 9.4e-05 21.1 0.2 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_16 PF13191.1 EDK36651.2 - 0.00041 20.3 0.1 0.0023 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EDK36651.2 - 0.0012 19.0 0.1 0.014 15.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EDK36651.2 - 0.0013 18.9 1.0 0.055 13.6 0.1 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EDK36651.2 - 0.0059 16.0 0.0 0.074 12.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 EDK36651.2 - 0.032 13.6 0.1 0.59 9.5 0.0 2.3 1 1 0 2 2 2 0 AAA-like domain SbcCD_C PF13558.1 EDK36651.2 - 0.066 13.1 0.2 0.33 10.9 0.2 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 EDK36651.2 - 0.1 13.4 0.2 0.68 10.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain DNA_pol_phi PF04931.8 EDK36652.1 - 3.3e-14 51.6 6.7 3.3e-14 51.6 4.7 1.7 2 0 0 2 2 2 1 DNA polymerase phi DUF2564 PF10819.3 EDK36652.1 - 0.012 15.6 1.4 0.13 12.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) Cbl_N PF02262.11 EDK36652.1 - 0.29 10.8 2.8 0.8 9.4 0.2 2.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DNA_pol_phi PF04931.8 EDK36653.2 - 6.5e-26 90.3 28.0 5.1e-13 47.7 0.2 3.4 2 1 1 3 3 3 3 DNA polymerase phi PfkB PF00294.19 EDK36654.1 - 1.3e-67 228.0 0.9 1.6e-67 227.7 0.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EDK36654.1 - 0.00037 19.7 0.1 0.0014 17.8 0.0 1.9 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase TRAM_LAG1_CLN8 PF03798.11 EDK36655.1 - 4e-38 130.9 15.4 4e-38 130.9 10.7 1.4 2 0 0 2 2 2 1 TLC domain Ras PF00071.17 EDK36656.1 - 1.4e-64 216.3 0.2 1.6e-64 216.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK36656.1 - 1.1e-20 74.2 0.0 1.6e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK36656.1 - 6.2e-17 61.3 0.1 7.9e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK36656.1 - 7.6e-08 31.7 0.0 8.8e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EDK36656.1 - 6e-05 22.5 0.2 0.00013 21.4 0.1 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK36656.1 - 6.8e-05 22.7 0.0 0.00011 22.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EDK36656.1 - 0.00063 19.0 0.0 0.00096 18.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.24 EDK36656.1 - 0.00099 19.3 0.0 0.017 15.3 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK36656.1 - 0.0013 18.8 0.0 0.003 17.7 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK36656.1 - 0.0068 16.4 0.2 0.073 13.0 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 EDK36656.1 - 0.023 13.9 0.0 0.065 12.4 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 EDK36656.1 - 0.029 13.8 0.0 1.2 8.5 0.0 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 EDK36656.1 - 0.032 13.7 0.0 0.097 12.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.13 EDK36656.1 - 0.099 11.6 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 Septin AAA_5 PF07728.9 EDK36656.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF3237 PF11578.3 EDK36657.1 - 9.5e-14 50.9 0.0 1.1e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Rpn3_C PF08375.6 EDK36658.2 - 2.8e-25 88.5 0.9 6.5e-25 87.3 0.6 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 EDK36658.2 - 1.3e-22 80.0 0.5 5.5e-22 78.0 0.3 2.1 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EDK36658.2 - 0.012 15.3 0.1 0.052 13.3 0.1 2.0 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 Med17 PF10156.4 EDK36659.2 - 2.3e-132 441.5 6.2 2.8e-132 441.3 4.3 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Ilm1 PF10311.4 EDK36660.1 - 4.4e-44 149.8 10.3 9.6e-44 148.7 7.2 1.5 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 ABC_membrane_3 PF13748.1 EDK36660.1 - 0.22 10.5 2.9 0.092 11.7 0.3 1.6 2 1 0 2 2 2 0 ABC transporter transmembrane region Cu-oxidase_3 PF07732.10 EDK36661.2 - 1.1e-33 115.3 4.3 7.2e-33 112.8 0.1 3.4 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 EDK36661.2 - 6.2e-30 103.5 10.1 2.9e-27 94.8 4.1 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EDK36661.2 - 8.3e-16 58.2 0.0 1.6e-14 54.0 0.0 2.9 3 1 0 3 3 3 1 Multicopper oxidase Zip PF02535.17 EDK36662.2 - 8.5e-51 172.8 0.2 9.8e-51 172.6 0.1 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Ribophorin_II PF05817.9 EDK36663.2 - 9.5e-08 30.7 0.4 1.2e-07 30.4 0.3 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Oxidored_q2 PF00420.19 EDK36663.2 - 0.084 12.4 0.1 0.084 12.4 0.1 2.3 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Peptidase_S24 PF00717.18 EDK36664.1 - 3.9e-08 32.8 0.1 1.6e-07 30.8 0.0 2.0 2 1 1 3 3 3 1 Peptidase S24-like Peptidase_S26 PF10502.4 EDK36664.1 - 0.00059 19.3 0.0 0.0015 18.0 0.0 1.6 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 CBFD_NFYB_HMF PF00808.18 EDK36666.1 - 1.5e-08 34.5 0.0 3.6e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK36666.1 - 0.00097 19.2 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pox_Ag35 PF03286.9 EDK36666.1 - 0.36 10.3 4.6 0.083 12.4 0.8 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MRP-L27 PF09809.4 EDK36667.1 - 7.3e-26 90.0 0.1 1.7e-25 88.8 0.1 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 DAO PF01266.19 EDK36668.2 - 1e-25 90.4 0.0 1.2e-25 90.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK36668.2 - 0.032 13.0 0.0 0.043 12.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.9 EDK36668.2 - 0.037 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EDK36668.2 - 0.083 11.7 0.0 0.16 10.8 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_8 PF13450.1 EDK36668.2 - 0.091 12.8 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EDK36668.2 - 0.22 11.9 0.7 0.65 10.4 0.5 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_81 PF03639.8 EDK36669.2 - 5.8e-237 788.1 28.6 5.8e-237 788.1 19.8 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 GRASP55_65 PF04495.9 EDK36670.2 - 1.8e-44 151.1 0.0 2.2e-40 137.8 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PfkB PF00294.19 EDK36671.2 - 4e-17 62.3 0.0 5.2e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EDK36671.2 - 0.00069 18.8 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase MFS_1 PF07690.11 EDK36672.2 - 8.7e-33 113.4 29.1 8.7e-33 113.4 20.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36672.2 - 7.7e-10 37.9 16.8 7.7e-10 37.9 11.6 3.7 2 2 0 2 2 2 1 Sugar (and other) transporter Ank PF00023.25 EDK36673.2 - 1.9e-16 58.9 1.9 8e-07 28.5 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 EDK36673.2 - 7.3e-16 58.2 1.7 2e-06 28.0 0.0 3.1 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EDK36673.2 - 9.1e-16 56.4 1.2 3.8e-05 23.5 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EDK36673.2 - 1.4e-12 47.7 3.2 2.6e-05 24.5 0.2 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 EDK36673.2 - 3.3e-12 46.2 2.9 3.1e-05 24.0 0.3 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.8 EDK36673.2 - 3.3e-08 33.1 0.0 3.5e-07 29.8 0.0 2.7 1 1 0 1 1 1 1 KilA-N domain IncA PF04156.9 EDK36673.2 - 0.58 9.7 10.5 0.78 9.3 4.1 2.3 2 0 0 2 2 2 0 IncA protein DUF555 PF04475.7 EDK36674.2 - 0.024 14.6 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF555) UQ_con PF00179.21 EDK36675.1 - 5e-38 129.6 0.0 7.1e-38 129.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rho_GDI PF02115.12 EDK36676.2 - 5.6e-13 48.7 0.0 6.7e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor RPN7 PF10602.4 EDK36677.2 - 1.7e-57 193.6 4.6 2.2e-57 193.2 2.4 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 EDK36677.2 - 1.4e-13 51.0 0.1 4e-13 49.5 0.1 1.8 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.1 EDK36677.2 - 0.027 14.4 1.0 0.16 11.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 EDK36677.2 - 0.03 14.0 0.1 0.19 11.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SpoVIF PF14069.1 EDK36677.2 - 0.043 13.5 0.2 0.27 11.0 0.1 2.2 2 0 0 2 2 2 0 Stage VI sporulation protein F HSCB_C PF07743.8 EDK36677.2 - 0.14 12.5 1.9 0.41 11.1 1.3 1.8 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Acyl-CoA_dh_1 PF00441.19 EDK36678.2 - 2.4e-24 86.1 0.8 3.7e-24 85.5 0.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 EDK36678.2 - 2.2e-12 46.3 0.2 1.3e-11 43.8 0.1 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 EDK36678.2 - 5.4e-11 43.0 0.0 1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 EDK36678.2 - 3.8e-07 30.4 0.7 6.2e-07 29.7 0.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain LSM PF01423.17 EDK36679.2 - 4.5e-14 51.7 0.1 6.8e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain GCD14 PF08704.5 EDK36680.1 - 5.9e-80 268.3 0.0 8.2e-80 267.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 EDK36680.1 - 4.2e-05 23.1 0.0 7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 EDK36680.1 - 0.0035 16.4 0.0 0.47 9.5 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 EDK36680.1 - 0.0047 16.5 0.0 0.0069 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36680.1 - 0.017 15.6 0.0 0.031 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36680.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 EDK36680.1 - 0.14 11.1 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Actin PF00022.14 EDK36681.2 - 3.3e-105 351.7 0.0 3.7e-105 351.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EDK36681.2 - 0.0023 16.5 0.0 0.011 14.4 0.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Pkinase PF00069.20 EDK36682.2 - 3.5e-49 167.2 0.0 6.3e-49 166.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36682.2 - 8.2e-20 70.9 0.0 2.2e-19 69.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36682.2 - 0.061 12.2 0.0 0.13 11.2 0.0 1.5 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 EDK36682.2 - 0.076 12.7 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 EDK36682.2 - 0.13 11.6 1.6 0.14 11.4 0.1 1.8 2 0 0 2 2 2 0 RIO1 family RTA1 PF04479.8 EDK36683.1 - 1.1e-47 162.3 12.2 1.1e-47 162.3 8.4 1.5 2 0 0 2 2 2 1 RTA1 like protein Glu-tRNAGln PF02686.10 EDK36684.2 - 0.0022 17.7 0.0 0.0082 15.9 0.0 1.9 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit DUF2040 PF09745.4 EDK36685.2 - 0.0035 17.1 15.2 0.0093 15.7 9.8 2.1 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF4548 PF15081.1 EDK36685.2 - 0.016 14.7 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Band_7 PF01145.20 EDK36686.2 - 4.4e-31 108.1 1.4 6.5e-31 107.6 1.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 EDK36686.2 - 0.00039 20.0 0.2 0.00058 19.4 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family CDP-OH_P_transf PF01066.16 EDK36687.2 - 4.2e-17 62.2 1.9 5.7e-17 61.8 1.3 1.2 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Tom22 PF04281.8 EDK36689.1 - 6.2e-49 165.0 1.9 7.4e-49 164.8 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF3402 PF11882.3 EDK36690.2 - 1.3e-89 301.1 7.0 1.3e-89 301.1 4.9 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.8 EDK36690.2 - 7e-23 80.9 11.7 4.4e-22 78.2 7.1 3.0 2 1 0 2 2 2 1 N1221-like protein Ribosomal_L17 PF01196.14 EDK36690.2 - 0.22 12.1 3.3 4.8 7.8 0.1 3.4 4 0 0 4 4 4 0 Ribosomal protein L17 AD PF09793.4 EDK36691.2 - 1.4e-06 28.0 0.0 3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain DUF4595 PF15283.1 EDK36691.2 - 0.041 13.5 0.3 0.084 12.5 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4595) with porin-like fold TonB_2 PF13103.1 EDK36691.2 - 0.075 13.0 2.2 2.6 8.1 0.1 3.3 3 1 0 3 3 3 0 TonB C terminal DUF1848 PF08902.6 EDK36691.2 - 0.099 12.1 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) GP3 PF03076.9 EDK36691.2 - 0.16 11.7 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Equine arteritis virus GP3 DSPc PF00782.15 EDK36692.2 - 9.3e-07 28.4 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EDK36692.2 - 1.4e-05 24.5 0.0 3.4e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EDK36692.2 - 0.001 19.1 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 EDK36692.2 - 0.033 14.4 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family TPR_11 PF13414.1 EDK36693.1 - 5.7e-38 128.3 20.9 2e-13 49.7 0.7 6.6 3 2 5 8 8 8 7 TPR repeat TPR_2 PF07719.12 EDK36693.1 - 1.8e-24 83.5 20.6 4.5e-08 32.4 0.0 10.5 8 2 2 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.23 EDK36693.1 - 1.1e-23 81.8 17.4 1.9e-08 33.5 0.1 9.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.1 EDK36693.1 - 3.4e-18 64.2 3.6 0.00012 22.0 0.1 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 EDK36693.1 - 4.8e-16 58.9 10.9 2.5e-05 24.8 0.0 5.5 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36693.1 - 2.1e-14 53.6 12.6 1.9e-05 24.9 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 EDK36693.1 - 1.5e-12 47.2 14.7 0.00022 21.0 0.0 6.9 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 EDK36693.1 - 3.1e-12 45.3 17.8 0.00013 21.4 0.1 8.1 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36693.1 - 7e-11 41.7 9.0 0.0051 17.3 0.0 7.4 4 3 4 8 8 8 3 Tetratricopeptide repeat TPR_7 PF13176.1 EDK36693.1 - 1.7e-07 30.5 3.1 4.4 7.3 0.0 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 EDK36693.1 - 4.3e-07 29.9 14.6 0.005 16.9 0.1 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 EDK36693.1 - 1.2e-06 28.2 2.9 0.019 14.8 0.0 5.3 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK36693.1 - 0.0016 18.7 0.1 0.0016 18.7 0.0 6.1 9 0 0 9 9 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 EDK36693.1 - 0.0033 16.5 8.6 0.6 9.1 3.6 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 EDK36693.1 - 0.0039 17.2 8.8 0.99 9.5 0.0 4.6 4 1 1 5 5 4 2 Tetratricopeptide repeat NST1 PF13945.1 EDK36693.1 - 0.16 12.0 5.6 0.067 13.2 1.8 1.9 2 0 0 2 2 2 0 Salt tolerance down-regulator Arrestin_N PF00339.24 EDK36694.2 - 1.7e-12 47.3 0.9 1.5e-08 34.5 0.1 3.2 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Vps26 PF03643.10 EDK36694.2 - 0.022 13.5 0.0 0.54 8.9 0.0 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 26 FKBP_C PF00254.23 EDK36695.1 - 2.8e-31 107.3 0.0 3.9e-31 106.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF59 PF01883.14 EDK36696.2 - 1.9e-08 34.1 0.1 3.1e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF59 Gryzun PF07919.7 EDK36697.2 - 3.5e-70 236.8 7.9 3.5e-70 236.8 5.5 1.4 2 0 0 2 2 2 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.3 EDK36697.2 - 2.5e-48 164.7 0.1 4.6e-48 163.8 0.0 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 NT-C2 PF10358.4 EDK36699.2 - 1.6e-44 150.8 1.5 2.8e-44 150.0 1.1 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins LSM PF01423.17 EDK36700.1 - 0.0027 17.2 0.0 0.0051 16.3 0.0 1.5 1 0 0 1 1 1 1 LSM domain Glycogen_syn PF05693.8 EDK36701.1 - 0 1113.5 0.0 0 1113.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 EDK36701.1 - 8.6e-08 31.7 0.0 3.9e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EDK36701.1 - 1.7e-07 31.4 0.1 3.2e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.6 EDK36701.1 - 5.4e-06 26.0 0.1 1.2e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain WD40 PF00400.27 EDK36702.2 - 8.6e-55 180.7 19.5 7.2e-11 41.5 0.1 13.2 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.7 EDK36702.2 - 9.3e-29 99.5 0.1 1.5e-28 98.9 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family RAB3GAP2_N PF14655.1 EDK36702.2 - 0.055 12.4 0.0 1.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.11 EDK36702.2 - 0.22 9.7 3.3 1.7 6.8 0.0 3.7 5 0 0 5 5 5 0 Cytochrome D1 heme domain Glypican PF01153.14 EDK36703.2 - 0.11 11.1 2.4 0.092 11.3 1.7 1.2 1 0 0 1 1 1 0 Glypican UPF0029 PF01205.14 EDK36704.1 - 9.3e-31 105.7 0.0 1.6e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 EDK36704.1 - 7.9e-12 45.0 0.4 1.9e-11 43.8 0.1 1.7 1 1 1 2 2 2 1 RWD domain Glucan_synthase PF02364.10 EDK36705.2 - 0 1162.2 0.4 0 1161.7 0.3 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EDK36705.2 - 2.9e-34 117.4 0.7 9.4e-34 115.8 0.5 2.0 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Peptidase_S8 PF00082.17 EDK36706.2 - 1.3e-43 149.2 5.4 1.7e-43 148.7 3.7 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EDK36706.2 - 0.056 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 ACC_central PF08326.7 EDK36707.2 - 9.2e-273 906.6 0.4 1.2e-272 906.2 0.3 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 EDK36707.2 - 1.4e-174 581.0 0.0 2.1e-174 580.5 0.0 1.3 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 EDK36707.2 - 4.9e-51 173.0 0.0 1e-50 171.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EDK36707.2 - 7.1e-24 84.0 0.1 1.6e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EDK36707.2 - 6.2e-21 74.3 0.0 4.9e-20 71.5 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 EDK36707.2 - 6.1e-18 64.2 1.4 1.1e-17 63.3 0.2 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 EDK36707.2 - 4.7e-11 42.7 0.0 1.3e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EDK36707.2 - 1.6e-08 33.6 0.0 0.011 14.4 0.0 3.2 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.1 EDK36707.2 - 0.00018 21.1 0.4 0.097 12.3 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 EDK36707.2 - 0.0021 17.5 0.0 0.0051 16.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 EDK36707.2 - 0.016 15.0 0.0 0.067 13.0 0.0 2.1 1 0 0 1 1 1 0 ATP-grasp domain RnfC_N PF13375.1 EDK36707.2 - 0.071 12.8 0.0 0.23 11.1 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Sugar_tr PF00083.19 EDK36708.2 - 2.5e-98 329.5 14.5 4e-98 328.9 10.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK36708.2 - 1.1e-22 80.3 31.5 4.1e-20 71.8 3.7 2.4 2 1 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK36708.2 - 0.00093 17.6 1.0 0.00093 17.6 0.7 2.8 3 1 0 3 3 3 2 MFS/sugar transport protein Tim17 PF02466.14 EDK36710.1 - 1.9e-29 102.3 0.4 2.4e-29 101.9 0.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.4 EDK36710.1 - 0.14 12.2 7.3 1.8 8.7 0.1 2.7 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_OmpA PF13436.1 EDK36710.1 - 1.1 8.9 5.1 0.27 10.8 0.4 2.1 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Dus PF01207.12 EDK36711.2 - 1.1e-46 159.0 0.0 3.3e-46 157.5 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) COX5A PF02284.11 EDK36711.2 - 0.078 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va SWIRM PF04433.12 EDK36712.2 - 2.6e-15 56.3 0.0 6.1e-15 55.1 0.0 1.7 2 0 0 2 2 2 1 SWIRM domain NT-C2 PF10358.4 EDK36712.2 - 0.059 12.8 0.1 0.14 11.6 0.0 1.7 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins Mis12 PF05859.7 EDK36714.2 - 8.9e-46 155.2 0.4 1.7e-45 154.3 0.3 1.5 1 0 0 1 1 1 1 Mis12 protein SHS2_Rpb7-N PF03876.12 EDK36716.1 - 4.2e-16 58.8 0.0 1.4e-15 57.1 0.0 1.8 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CorA PF01544.13 EDK36717.2 - 8.8e-07 28.2 10.4 4e-06 26.0 7.2 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein vATP-synt_E PF01991.13 EDK36718.1 - 2.5e-57 193.3 21.1 2.9e-57 193.1 14.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit HK97-gp10_like PF04883.7 EDK36718.1 - 0.0058 17.5 3.1 0.78 10.7 0.1 2.7 1 1 1 2 2 2 2 Bacteriophage HK97-gp10, putative tail-component DUF2250 PF10007.4 EDK36718.1 - 0.32 10.9 7.7 0.045 13.6 1.5 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DUF4363 PF14276.1 EDK36718.1 - 1.4 8.6 9.8 6.7 6.4 0.1 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4363) Phlebovirus_NSM PF07246.6 EDK36718.1 - 3.3 6.7 9.6 5.8 5.9 6.7 1.4 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Mito_carr PF00153.22 EDK36719.1 - 9.2e-55 182.3 4.6 6.7e-19 67.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Spc97_Spc98 PF04130.8 EDK36720.2 - 1.6e-68 231.3 22.5 2.5e-68 230.7 15.6 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family Aminotran_1_2 PF00155.16 EDK36721.2 - 2.7e-75 253.6 0.0 3.5e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EDK36721.2 - 1.4e-06 27.3 0.0 1e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EDK36721.2 - 2.1e-06 26.2 0.0 3.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EDK36721.2 - 0.003 16.6 0.4 0.016 14.2 0.3 1.9 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 EDK36721.2 - 0.0036 16.4 0.1 0.0079 15.3 0.1 1.6 1 0 0 1 1 1 1 Beta-eliminating lyase CART PF06373.6 EDK36721.2 - 0.031 14.2 0.0 0.076 12.9 0.0 1.6 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) MFS_1 PF07690.11 EDK36722.1 - 6.1e-21 74.5 19.6 6.1e-21 74.5 13.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BATS PF06968.8 EDK36723.2 - 1.9e-29 101.3 0.1 6.3e-29 99.6 0.0 2.0 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 EDK36723.2 - 8.2e-14 52.1 0.1 2.8e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily IMD PF08397.6 EDK36724.2 - 6.9e-05 22.2 4.7 0.00011 21.6 3.2 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain Arfaptin PF06456.8 EDK36724.2 - 0.033 13.5 0.1 0.033 13.5 0.0 2.2 1 1 1 2 2 2 0 Arfaptin-like domain BRO1 PF03097.13 EDK36724.2 - 0.07 11.8 4.6 0.094 11.4 1.9 1.9 2 0 0 2 2 2 0 BRO1-like domain Amidase PF01425.16 EDK36725.1 - 4e-98 329.1 0.0 4.8e-98 328.8 0.0 1.1 1 0 0 1 1 1 1 Amidase DUF3439 PF11921.3 EDK36725.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSF PF00474.12 EDK36726.2 - 6.1e-09 35.0 16.2 6.1e-09 35.0 11.2 1.8 2 0 0 2 2 2 1 Sodium:solute symporter family PBP1_TM PF14812.1 EDK36726.2 - 0.0094 16.2 0.4 0.019 15.2 0.3 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal 7tm_7 PF08395.7 EDK36726.2 - 0.015 14.3 0.3 0.015 14.3 0.2 1.9 2 0 0 2 2 2 0 7tm Chemosensory receptor Fungal_trans PF04082.13 EDK36727.2 - 1.9e-20 72.8 0.3 3e-20 72.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribonuclease_3 PF00636.21 EDK36728.2 - 3.2e-20 72.6 0.0 9.8e-20 71.1 0.0 1.9 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EDK36728.2 - 7.7e-18 64.6 0.2 1.8e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 EDK36728.2 - 2e-13 50.7 0.0 2.4e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif Cation_efflux PF01545.16 EDK36728.2 - 0.13 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Cation efflux family Ribosomal_L10 PF00466.15 EDK36729.2 - 2.4e-05 24.1 0.0 5.7e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Methyltransf_4 PF02390.12 EDK36730.2 - 4.9e-60 201.9 0.1 6.3e-60 201.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 EDK36730.2 - 1.5e-05 25.5 0.0 2.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK36730.2 - 4.2e-05 22.9 0.0 0.00038 19.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 EDK36730.2 - 0.0014 18.1 0.1 0.0021 17.6 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EDK36730.2 - 0.0027 16.8 0.0 0.0047 16.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EDK36730.2 - 0.0053 16.4 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK36730.2 - 0.009 16.0 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 EDK36730.2 - 0.017 14.1 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_11 PF08241.7 EDK36730.2 - 0.023 15.1 0.0 0.9 10.0 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36730.2 - 0.027 14.9 0.0 0.061 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 EDK36730.2 - 0.049 13.9 0.0 0.092 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Reticulon PF02453.12 EDK36731.2 - 1.2e-24 86.8 1.1 1.6e-24 86.4 0.8 1.1 1 0 0 1 1 1 1 Reticulon DUF95 PF01944.12 EDK36731.2 - 0.044 13.4 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF95 VPS11_C PF12451.3 EDK36732.2 - 1.6e-15 56.6 0.7 4.4e-15 55.2 0.5 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-RING_2 PF13639.1 EDK36732.2 - 0.00025 20.8 6.7 0.00085 19.1 4.7 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EDK36732.2 - 0.00073 19.2 8.2 0.002 17.7 5.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK36732.2 - 0.00083 19.3 6.6 0.0025 17.8 4.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.1 EDK36732.2 - 0.017 15.2 4.8 0.049 13.7 3.3 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-Apc11 PF12861.2 EDK36732.2 - 0.019 14.8 2.9 0.046 13.5 2.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EDK36732.2 - 0.057 13.5 4.3 0.17 12.0 3.0 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger zf-MIZ PF02891.15 EDK36732.2 - 0.057 12.9 6.4 0.13 11.8 4.4 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Sep15_SelM PF08806.6 EDK36732.2 - 0.07 12.8 0.5 0.78 9.5 0.0 3.1 3 0 0 3 3 3 0 Sep15/SelM redox domain TPR_11 PF13414.1 EDK36732.2 - 0.14 11.8 0.1 0.6 9.7 0.0 2.0 2 0 0 2 2 2 0 TPR repeat Prok-RING_1 PF14446.1 EDK36732.2 - 0.19 11.5 3.7 0.43 10.3 0.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-Nse PF11789.3 EDK36732.2 - 0.55 9.7 7.9 0.62 9.6 3.4 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Acetyltransf_1 PF00583.19 EDK36735.2 - 1.1e-13 51.0 0.0 1.4e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EDK36735.2 - 2.2e-10 40.5 0.0 3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EDK36735.2 - 6.3e-05 22.8 0.0 7.2e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK36735.2 - 0.0021 18.1 0.0 0.0024 17.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1620 PF07774.8 EDK36736.2 - 2.2e-64 216.7 3.9 2.2e-64 216.7 2.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 EDK36736.2 - 0.0036 16.7 0.4 0.16 11.4 0.0 2.7 2 1 0 2 2 2 1 PQQ-like domain YxiJ PF14176.1 EDK36736.2 - 0.054 13.6 0.1 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 YxiJ-like protein Zn_clus PF00172.13 EDK36737.2 - 1.6e-07 31.0 9.8 2.8e-07 30.3 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rpr2 PF04032.11 EDK36738.2 - 1.1e-13 50.7 1.0 1.5e-13 50.3 0.1 1.6 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DZR PF12773.2 EDK36738.2 - 0.051 13.3 0.1 0.095 12.5 0.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon A2L_zn_ribbon PF08792.5 EDK36738.2 - 1.4 8.4 5.5 4.8 6.7 0.2 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Pex24p PF06398.6 EDK36739.2 - 1.1e-62 211.9 8.4 1.6e-62 211.4 5.8 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin SIR2 PF02146.12 EDK36740.2 - 1e-34 119.8 0.0 2.1e-33 115.5 0.0 2.2 1 1 0 1 1 1 1 Sir2 family BmKX PF09132.5 EDK36740.2 - 0.13 12.1 0.0 0.39 10.6 0.0 1.8 1 0 0 1 1 1 0 BmKX Pkinase PF00069.20 EDK36741.2 - 9.6e-77 257.6 0.0 1.3e-76 257.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36741.2 - 2.6e-38 131.5 0.0 3.8e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 EDK36741.2 - 6.5e-18 64.6 1.1 1.1e-17 63.8 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 EDK36741.2 - 1.7e-08 33.8 0.0 6.2e-08 31.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like YukC PF10140.4 EDK36741.2 - 6e-05 21.7 0.2 9e-05 21.1 0.1 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.17 EDK36741.2 - 8.7e-05 21.9 0.2 0.00016 21.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 EDK36741.2 - 0.006 15.6 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2443 PF10398.4 EDK36741.2 - 0.014 15.2 0.2 0.029 14.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) Innate_immun PF12782.2 EDK36741.2 - 0.032 13.4 2.1 0.046 12.9 1.5 1.3 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family APH PF01636.18 EDK36741.2 - 0.042 13.5 0.2 0.2 11.3 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1421 PF07223.6 EDK36741.2 - 0.049 13.4 0.6 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1421) RuvA_C PF07499.8 EDK36741.2 - 0.14 12.3 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 RuvA, C-terminal domain CPSF73-100_C PF11718.3 EDK36741.2 - 0.14 11.5 1.1 0.24 10.7 0.7 1.3 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term PWI PF01480.12 EDK36742.2 - 7.2e-16 58.0 0.5 1.1e-15 57.4 0.3 1.3 1 0 0 1 1 1 1 PWI domain Hid1 PF12722.2 EDK36742.2 - 2.5 5.6 9.9 2.5 5.6 6.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AUX_IAA PF02309.11 EDK36742.2 - 2.6 7.7 10.4 3.4 7.3 7.2 1.1 1 0 0 1 1 1 0 AUX/IAA family YTH PF04146.10 EDK36743.2 - 3.5e-45 153.0 0.2 5.2e-45 152.4 0.1 1.3 1 0 0 1 1 1 1 YT521-B-like domain COQ7 PF03232.8 EDK36744.2 - 2.6e-76 254.9 0.0 4.1e-76 254.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.12 EDK36744.2 - 0.093 13.0 0.0 0.3 11.4 0.0 1.8 2 0 0 2 2 2 0 Rubrerythrin Nuf2 PF03800.9 EDK36745.2 - 4.1e-45 153.3 3.6 6.7e-45 152.6 0.1 2.5 2 0 0 2 2 2 1 Nuf2 family ATG16 PF08614.6 EDK36745.2 - 0.02 14.6 56.9 0.15 11.9 15.1 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) BRCA2 PF00634.13 EDK36745.2 - 0.035 13.3 1.1 1.1 8.6 0.2 3.1 3 0 0 3 3 3 0 BRCA2 repeat Bacillus_HBL PF05791.6 EDK36745.2 - 0.66 9.3 33.8 0.033 13.5 2.2 4.2 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) TMCO5 PF14992.1 EDK36745.2 - 2.8 7.0 51.6 0.18 10.9 18.0 2.3 1 1 1 2 2 2 0 TMCO5 family GAS PF13851.1 EDK36745.2 - 5 6.2 60.5 0.18 10.9 15.9 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 EDK36745.2 - 8.5 6.2 54.8 3.8 7.3 10.0 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MFS_1 PF07690.11 EDK36746.2 - 1.1e-27 96.7 42.4 5e-27 94.5 28.8 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK36746.2 - 8.2e-09 34.2 22.3 1.3e-08 33.5 15.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EDK36746.2 - 3e-05 22.7 10.0 3e-05 22.7 6.9 3.3 2 1 2 4 4 4 1 Sugar (and other) transporter Git3_C PF11970.3 EDK36747.2 - 2.4e-30 104.0 5.5 4e-30 103.4 3.8 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Git3 PF11710.3 EDK36748.1 - 1.1e-72 243.8 12.8 1.2e-72 243.7 8.9 1.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.16 EDK36748.1 - 0.00092 18.4 6.5 0.0012 18.0 4.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 EDK36748.1 - 0.14 11.0 9.0 0.19 10.6 6.2 1.3 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor AA_permease PF00324.16 EDK36750.2 - 8.6e-100 334.3 26.6 1e-99 334.0 18.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK36750.2 - 1.9e-20 72.8 28.4 2.6e-20 72.3 19.7 1.1 1 0 0 1 1 1 1 Amino acid permease Sod_Cu PF00080.15 EDK36751.2 - 3.1e-23 82.4 0.1 4.2e-23 82.0 0.1 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) OKR_DC_1_N PF03709.10 EDK36751.2 - 0.033 14.2 0.0 0.62 10.1 0.0 2.1 1 1 1 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Abhydro_lipase PF04083.11 EDK36752.2 - 7.8e-22 76.4 0.1 1.6e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 EDK36752.2 - 3.7e-17 62.6 0.1 6.8e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK36752.2 - 3.5e-09 36.8 0.0 7.1e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK36752.2 - 0.00023 20.9 0.0 0.0036 17.0 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EDK36752.2 - 0.0066 15.9 0.1 2.1 7.7 0.0 2.8 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase FSH1 PF03959.8 EDK36752.2 - 0.054 12.9 0.0 3.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DUF1770 PF08589.5 EDK36752.2 - 0.13 12.9 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1770) zf-C2H2_2 PF12756.2 EDK36753.2 - 0.006 16.6 2.6 0.013 15.5 1.8 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF2457 PF10446.4 EDK36753.2 - 0.01 14.5 26.8 0.015 14.0 18.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 EDK36753.2 - 0.018 13.5 13.6 0.025 13.1 9.4 1.1 1 0 0 1 1 1 0 Daxx Family zf-C2H2 PF00096.21 EDK36753.2 - 0.2 12.0 9.5 0.48 10.8 1.3 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Vfa1 PF08432.5 EDK36753.2 - 0.28 11.2 7.8 0.51 10.3 5.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 zf-C2H2_4 PF13894.1 EDK36753.2 - 0.32 11.4 11.4 0.09 13.1 1.3 2.8 3 0 0 3 3 2 0 C2H2-type zinc finger Sigma70_ner PF04546.8 EDK36753.2 - 0.57 9.7 16.8 0.93 9.0 11.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2796 PF10986.3 EDK36753.2 - 0.62 10.0 9.3 1.1 9.1 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Nop14 PF04147.7 EDK36753.2 - 1.3 6.8 22.7 1.8 6.3 15.7 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 EDK36753.2 - 1.7 7.6 17.6 2.6 7.0 12.2 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.7 EDK36753.2 - 1.8 7.7 17.5 2.6 7.2 12.1 1.2 1 0 0 1 1 1 0 SDA1 FYDLN_acid PF09538.5 EDK36753.2 - 2.3 8.8 24.2 1.1 9.8 15.2 1.7 2 0 0 2 2 1 0 Protein of unknown function (FYDLN_acid) BTV_NS2 PF04514.7 EDK36753.2 - 2.5 6.8 13.9 4.1 6.1 9.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Retinal PF15449.1 EDK36753.2 - 2.5 5.6 8.8 4.4 4.8 6.1 1.3 1 0 0 1 1 1 0 Retinal protein CDC45 PF02724.9 EDK36753.2 - 3.3 5.6 16.6 4.5 5.1 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 EDK36753.2 - 4.4 6.6 16.3 0.74 9.1 8.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) FAM176 PF14851.1 EDK36753.2 - 5.4 6.6 8.8 11 5.6 6.1 1.5 1 0 0 1 1 1 0 FAM176 family CobT PF06213.7 EDK36753.2 - 8.8 5.3 20.6 13 4.7 14.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT zf-C2H2_4 PF13894.1 EDK36755.2 - 3.1e-05 23.9 6.5 0.017 15.3 0.2 3.3 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.21 EDK36755.2 - 0.00015 21.8 7.9 0.0088 16.3 0.0 3.3 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.7 EDK36755.2 - 0.019 15.0 2.5 0.074 13.1 1.3 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 EDK36755.2 - 0.069 13.4 4.7 0.14 12.5 1.2 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 EDK36755.2 - 1.1 9.6 4.5 10 6.5 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain BCDHK_Adom3 PF10436.4 EDK36756.2 - 1.9e-43 147.8 0.1 3.5e-43 146.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EDK36756.2 - 7.7e-11 41.6 0.0 1.1e-09 37.9 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EDK36756.2 - 5.4e-05 22.8 0.0 9.6e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CRC_subunit PF08624.5 EDK36757.2 - 1.9e-57 193.0 0.2 3.2e-57 192.3 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit FRQ PF09421.5 EDK36757.2 - 0.12 10.1 9.3 0.17 9.6 6.4 1.1 1 0 0 1 1 1 0 Frequency clock protein YL1 PF05764.8 EDK36757.2 - 0.13 11.9 18.1 0.2 11.2 12.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CDC27 PF09507.5 EDK36757.2 - 0.41 9.8 22.8 0.58 9.3 15.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.7 EDK36757.2 - 0.41 8.4 21.1 0.55 8.0 14.6 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 EDK36757.2 - 1.6 7.6 22.3 2.3 7.2 15.4 1.1 1 0 0 1 1 1 0 BUD22 Daxx PF03344.10 EDK36757.2 - 2.9 6.2 20.3 4.1 5.7 14.1 1.1 1 0 0 1 1 1 0 Daxx Family HUN PF08729.5 EDK36758.2 - 1.2e-12 47.5 0.2 1.2e-12 47.5 0.2 2.5 2 0 0 2 2 2 1 HPC2 and ubinuclein domain RRN3 PF05327.6 EDK36758.2 - 9.5 4.1 14.1 22 3.0 9.8 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2370 PF10176.4 EDK36759.2 - 7.5e-87 290.5 1.7 9.7e-87 290.1 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2370) TMEM51 PF15345.1 EDK36759.2 - 0.22 11.2 2.9 0.23 11.1 0.0 2.5 3 1 0 3 3 3 0 Transmembrane protein 51 DUF2681 PF10883.3 EDK36759.2 - 2.2 8.5 5.9 0.4 10.9 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) adh_short PF00106.20 EDK36760.2 - 3e-28 98.8 0.0 4.5e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK36760.2 - 8.6e-19 68.2 0.1 1.1e-18 67.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK36760.2 - 1.5e-11 44.3 0.0 2.3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK36760.2 - 3.3e-05 23.4 0.1 7e-05 22.3 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 EDK36760.2 - 0.00052 19.2 0.0 0.00093 18.4 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.12 EDK36760.2 - 0.041 12.7 0.0 0.083 11.7 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain Eno-Rase_NADH_b PF12242.3 EDK36760.2 - 0.092 12.5 0.2 0.24 11.2 0.1 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase SNF5 PF04855.7 EDK36761.2 - 4.6e-61 206.3 4.8 6.6e-60 202.6 0.6 2.6 2 1 0 2 2 2 1 SNF5 / SMARCB1 / INI1 DNA_pol_B PF00136.16 EDK36762.2 - 5.2e-114 381.5 6.6 7.7e-114 381.0 4.5 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 EDK36762.2 - 7.3e-70 234.1 0.6 1.3e-69 233.3 0.4 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 EDK36762.2 - 5.1e-35 120.8 0.0 1.1e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 EDK36762.2 - 7.1e-25 86.6 10.4 2.8e-24 84.6 7.2 2.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Syntaxin_2 PF14523.1 EDK36764.2 - 2.1e-17 62.9 13.4 2.1e-17 62.9 9.3 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.14 EDK36764.2 - 3.6e-16 58.5 7.6 3.6e-16 58.5 5.3 3.4 4 0 0 4 4 4 1 SNARE domain Synaptobrevin PF00957.16 EDK36764.2 - 9.2e-05 21.9 0.5 9.2e-05 21.9 0.4 2.8 4 1 0 4 4 4 1 Synaptobrevin Cep57_CLD_2 PF14197.1 EDK36764.2 - 0.00033 20.5 0.7 0.00033 20.5 0.5 3.9 3 2 0 3 3 3 1 Centrosome localisation domain of PPC89 MCPsignal PF00015.16 EDK36764.2 - 0.0057 16.2 2.4 0.0057 16.2 1.7 2.5 1 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF883 PF05957.8 EDK36764.2 - 0.15 12.4 9.9 0.18 12.2 0.8 3.4 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) ApoO PF09769.4 EDK36764.2 - 0.17 11.5 10.8 1.2 8.8 0.1 3.1 1 1 1 3 3 3 0 Apolipoprotein O DUF2730 PF10805.3 EDK36764.2 - 1.7 8.3 10.0 0.087 12.5 0.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) LMBR1 PF04791.11 EDK36764.2 - 5.3 5.5 7.6 4.8 5.6 4.4 1.7 1 1 0 1 1 1 0 LMBR1-like membrane protein Glyco_transf_15 PF01793.11 EDK36764.2 - 7.2 5.4 8.6 3.3 6.5 2.8 2.2 1 1 1 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase AATase PF07247.7 EDK36765.2 - 4.1e-77 259.7 1.3 5e-77 259.4 0.9 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EDK36765.2 - 5.6e-05 22.1 0.5 0.14 11.0 0.0 2.1 2 0 0 2 2 2 2 Condensation domain Voltage_CLC PF00654.15 EDK36766.2 - 1.6e-87 293.8 21.0 1.6e-87 293.8 14.5 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 EDK36766.2 - 2.1e-13 49.8 0.1 5e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 CBS domain UCR_Fe-S_N PF10399.4 EDK36766.2 - 0.26 10.4 1.8 3.9 6.7 1.2 2.7 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Urb2 PF10441.4 EDK36767.2 - 2.6e-56 190.7 7.5 2.6e-56 190.7 5.2 4.0 5 0 0 5 5 5 2 Urb2/Npa2 family Ribosomal_L7Ae PF01248.21 EDK36768.1 - 3.5e-26 90.5 0.0 4.2e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EDK36768.1 - 0.00088 19.1 0.0 0.00093 19.0 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 EDK36768.1 - 0.0053 16.4 0.0 0.0071 16.1 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain ATP-synt_C PF00137.16 EDK36769.1 - 4.2e-22 77.8 17.8 2.8e-19 68.7 7.6 2.0 2 0 0 2 2 2 2 ATP synthase subunit C TCR_zetazeta PF11628.3 EDK36769.1 - 2.7 7.5 5.2 14 5.2 0.2 2.3 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain Nucleopor_Nup85 PF07575.8 EDK36770.2 - 1.9e-63 214.5 5.6 3.3e-63 213.7 3.9 1.3 1 1 0 1 1 1 1 Nup85 Nucleoporin CPSF_A PF03178.10 EDK36771.2 - 0.0019 17.3 0.0 0.0058 15.7 0.0 1.8 1 0 0 1 1 1 1 CPSF A subunit region HECT PF00632.20 EDK36772.2 - 3e-81 273.0 0.1 5.5e-81 272.1 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UCR_TM PF02921.9 EDK36773.1 - 1.4e-21 76.5 1.9 2.3e-21 75.7 1.3 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 EDK36773.1 - 3.3e-18 65.0 0.0 5.9e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Transp_cyt_pur PF02133.10 EDK36773.1 - 0.1 11.1 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin CAAD PF14159.1 EDK36774.1 - 0.082 12.5 0.3 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase WTF PF03303.8 EDK36774.1 - 0.15 11.4 1.7 0.18 11.1 1.2 1.1 1 0 0 1 1 1 0 WTF protein DUF3014 PF11219.3 EDK36776.2 - 0.0095 15.8 0.3 0.09 12.6 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3014) Mito_carr PF00153.22 EDK36777.2 - 7.1e-29 99.3 0.8 1.6e-14 53.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CFIA_Pcf11 PF11526.3 EDK36778.2 - 3.3e-20 72.0 6.1 2.1e-19 69.4 4.2 2.3 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.14 EDK36778.2 - 0.019 14.5 0.0 0.064 12.8 0.0 1.9 1 0 0 1 1 1 0 VHS domain ADK PF00406.17 EDK36779.1 - 4.9e-61 205.0 0.1 6.7e-61 204.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 EDK36779.1 - 1.5e-14 53.3 0.0 4.4e-14 51.8 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.1 EDK36779.1 - 0.0004 20.2 0.0 0.00068 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK36779.1 - 0.00045 21.0 0.0 0.00075 20.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK36779.1 - 0.0019 18.5 0.1 0.0044 17.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EDK36779.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EDK36779.1 - 0.078 12.0 0.1 0.11 11.5 0.0 1.4 1 1 0 1 1 1 0 Zeta toxin AAA_5 PF07728.9 EDK36779.1 - 0.085 12.5 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2424 PF10340.4 EDK36780.2 - 1.1e-23 83.5 0.0 1.4e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EDK36780.2 - 3e-12 46.5 0.0 4.6e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK36780.2 - 0.014 15.1 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Tfb2 PF03849.9 EDK36780.2 - 0.15 10.7 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 DUF2424 PF10340.4 EDK36781.2 - 4.5e-27 94.6 0.0 6.9e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EDK36781.2 - 2.8e-16 59.7 0.0 4.5e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK36781.2 - 0.015 15.0 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2424 PF10340.4 EDK36782.2 - 7.3e-32 110.4 0.1 1.2e-31 109.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EDK36782.2 - 2.8e-14 53.2 0.0 4.5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK36782.2 - 0.021 14.5 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.15 EDK36782.2 - 0.12 12.6 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Malic_M PF03949.10 EDK36783.2 - 1.8e-78 263.6 0.0 2.9e-78 262.9 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 EDK36783.2 - 1e-62 210.9 0.0 1.7e-62 210.1 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain H2TH PF06831.9 EDK36784.2 - 6.3e-20 70.7 0.0 1.3e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.19 EDK36784.2 - 2.4e-16 60.1 0.1 5.3e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain FAM178 PF14816.1 EDK36784.2 - 0.13 10.9 1.8 0.22 10.2 1.3 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 Snf7 PF03357.16 EDK36785.2 - 4.2e-43 146.6 16.9 4.9e-43 146.4 11.7 1.1 1 0 0 1 1 1 1 Snf7 Seryl_tRNA_N PF02403.17 EDK36785.2 - 0.036 14.0 14.6 0.55 10.2 2.6 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Mod_r PF07200.8 EDK36785.2 - 0.036 13.9 16.0 0.055 13.3 6.5 2.6 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.7 EDK36785.2 - 0.09 13.0 12.2 4.2 7.7 0.0 3.9 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Exonuc_VII_L PF02601.10 EDK36785.2 - 0.22 10.6 7.3 0.31 10.2 5.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2120 PF09893.4 EDK36785.2 - 0.24 11.3 3.1 0.41 10.5 2.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) EMP24_GP25L PF01105.19 EDK36785.2 - 0.34 10.5 4.5 3.3 7.3 0.0 2.5 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Atg14 PF10186.4 EDK36785.2 - 0.51 9.2 9.5 0.72 8.7 6.6 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1825 PF08855.5 EDK36785.2 - 0.57 10.2 8.6 0.11 12.4 2.0 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF1825) DUF771 PF05595.6 EDK36785.2 - 0.77 9.7 3.7 0.63 9.9 1.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF771) FlaC_arch PF05377.6 EDK36785.2 - 1.1 9.2 5.3 14 5.7 0.0 3.6 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 EDK36785.2 - 1.8 7.6 8.8 6.3 5.8 3.3 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DASH_Dam1 PF08653.5 EDK36785.2 - 2.8 7.7 10.2 15 5.4 0.0 3.8 3 1 0 3 3 3 0 DASH complex subunit Dam1 DUF972 PF06156.8 EDK36785.2 - 6.3 7.1 12.8 8.1 6.8 3.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF4337 PF14235.1 EDK36785.2 - 6.7 6.5 9.8 0.45 10.3 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF3573 PF12097.3 EDK36785.2 - 9.5 4.7 6.9 14 4.1 4.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Methyltransf_23 PF13489.1 EDK36786.2 - 2.2e-23 82.7 0.0 3e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK36786.2 - 4.9e-16 58.6 0.0 6.1e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK36786.2 - 1.3e-14 54.4 0.0 2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK36786.2 - 4.1e-14 52.8 0.0 6.1e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK36786.2 - 8.4e-12 45.6 0.0 1.4e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EDK36786.2 - 2.3e-09 36.7 0.1 3e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 EDK36786.2 - 7.8e-08 32.6 0.0 1.1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK36786.2 - 3.4e-07 29.7 0.0 6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 EDK36786.2 - 4.5e-07 29.2 0.0 6.8e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.6 EDK36786.2 - 3.5e-06 26.5 0.0 4.6e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_26 PF13659.1 EDK36786.2 - 7.8e-06 25.9 0.0 1.7e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EDK36786.2 - 1.9e-05 23.5 0.0 2.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.7 EDK36786.2 - 2.8e-05 23.5 0.1 4.6e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.14 EDK36786.2 - 0.00022 20.8 0.0 0.0023 17.4 0.0 2.2 1 1 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.1 EDK36786.2 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.12 EDK36786.2 - 0.0066 15.4 0.4 0.0096 14.8 0.2 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase DREV PF05219.7 EDK36786.2 - 0.017 14.0 0.0 0.028 13.3 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase TehB PF03848.9 EDK36786.2 - 0.037 13.1 0.0 0.053 12.6 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 EDK36786.2 - 0.057 12.4 0.0 0.32 10.0 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase YL1 PF05764.8 EDK36787.2 - 1.9e-37 129.1 49.3 7.6e-36 123.9 34.2 2.1 1 1 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.6 EDK36788.2 - 7.4e-11 41.4 0.0 1.7e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain MFS_1 PF07690.11 EDK36790.2 - 1.9e-39 135.3 29.7 1.9e-39 135.3 20.6 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Mpv17_PMP22 PF04117.7 EDK36791.2 - 2.6e-10 39.7 2.0 7.3e-10 38.3 1.4 1.9 1 0 0 1 1 1 1 Mpv17 / PMP22 family DEAD PF00270.24 EDK36792.2 - 6.6e-34 116.8 1.3 1.4e-33 115.7 0.9 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK36792.2 - 4.2e-23 80.9 0.1 3.5e-21 74.8 0.0 3.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK36792.2 - 1.1e-05 25.4 0.4 8.6e-05 22.4 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DnaI_N PF07319.6 EDK36792.2 - 0.08 13.2 0.5 1.2 9.4 0.1 2.8 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus Form_Nir_trans PF01226.12 EDK36793.2 - 1.6e-61 207.3 26.5 2e-61 207.1 18.4 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter zf-RING_2 PF13639.1 EDK36794.2 - 6.2e-08 32.3 11.2 6.2e-08 32.3 7.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.1 EDK36794.2 - 1.1e-07 31.5 2.6 1.1e-07 31.5 1.8 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4 PF00097.20 EDK36794.2 - 1.3e-07 31.1 12.8 1.3e-07 31.1 8.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK36794.2 - 3.3e-07 30.2 19.5 3.8e-07 30.0 8.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK36794.2 - 4.2e-06 26.3 15.3 1.6e-05 24.5 8.2 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK36794.2 - 7.1e-06 25.5 14.3 2.1e-05 24.1 6.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.22 EDK36794.2 - 1.6e-05 24.2 0.1 5.7e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 SAP domain zf-C3HC4_4 PF15227.1 EDK36794.2 - 1.7e-05 24.6 11.7 1.7e-05 24.6 8.1 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EDK36794.2 - 0.00019 21.0 3.9 0.00019 21.0 2.7 3.1 2 1 1 3 3 3 1 RING-type zinc-finger zf-rbx1 PF12678.2 EDK36794.2 - 0.00021 21.3 11.8 0.00056 19.9 5.5 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger Prok-RING_4 PF14447.1 EDK36794.2 - 0.003 17.0 8.2 0.021 14.3 3.3 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.3 EDK36794.2 - 0.055 12.9 10.7 0.079 12.4 5.3 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-Apc11 PF12861.2 EDK36794.2 - 0.2 11.5 5.9 0.094 12.5 2.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-TFIIB PF13453.1 EDK36794.2 - 0.22 10.7 2.2 0.62 9.3 0.4 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger DUF1272 PF06906.6 EDK36794.2 - 3.1 7.7 9.0 2.4 8.0 4.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-P11 PF03854.9 EDK36794.2 - 8.1 6.0 13.8 4.8 6.7 6.9 2.6 2 1 0 2 2 2 0 P-11 zinc finger WD40 PF00400.27 EDK36795.2 - 1.1e-08 34.6 0.5 2.6e-06 27.0 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Phos_pyr_kin PF08543.7 EDK36796.2 - 3.5e-09 36.2 0.0 7.2e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 EDK36796.2 - 0.0012 18.0 0.0 0.0043 16.2 0.0 2.0 1 1 1 3 3 3 1 pfkB family carbohydrate kinase Lipase_3 PF01764.20 EDK36797.2 - 3.7e-07 29.8 0.0 7.7e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EDK36797.2 - 0.017 14.8 0.0 0.16 11.7 0.0 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK36797.2 - 0.069 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family SUR7 PF06687.7 EDK36798.2 - 1.8e-36 125.7 15.5 2.4e-36 125.2 10.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EDK36798.2 - 0.0013 18.6 10.1 0.0013 18.6 7.0 1.6 1 1 1 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 NfeD PF01957.13 EDK36798.2 - 0.27 11.3 3.9 0.58 10.2 2.7 1.6 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF3754 PF12576.3 EDK36798.2 - 0.42 10.2 2.0 0.76 9.3 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) DUF4271 PF14093.1 EDK36798.2 - 0.91 9.1 13.8 0.046 13.4 5.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) PRA1 PF03208.14 EDK36798.2 - 2.4 7.5 14.3 0.15 11.4 3.9 2.3 2 0 0 2 2 2 0 PRA1 family protein Pkinase PF00069.20 EDK36799.1 - 3.7e-40 137.7 0.0 5.5e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36799.1 - 6.7e-22 77.8 0.0 1.3e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36799.1 - 0.00038 19.5 0.0 0.0009 18.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK36799.1 - 0.1 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fmp27 PF10344.4 EDK36800.2 - 5.8e-222 738.9 38.8 5.8e-222 738.9 26.9 2.4 3 0 0 3 3 3 1 Mitochondrial protein from FMP27 Apt1 PF10351.4 EDK36800.2 - 2.6e-132 441.9 19.5 2.6e-132 441.9 13.5 2.8 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.4 EDK36800.2 - 5.4e-112 374.6 19.8 4.9e-65 219.7 5.1 4.4 4 1 1 5 5 5 2 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.4 EDK36800.2 - 6.3e-56 188.6 0.0 1.5e-55 187.3 0.0 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 EDK36800.2 - 2.6e-50 170.2 0.6 4.6e-49 166.1 0.1 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 EDK36800.2 - 3.6e-28 98.0 0.0 2.5e-27 95.3 0.0 2.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain RRM_1 PF00076.17 EDK36801.2 - 1.7e-11 43.5 0.0 4.1e-11 42.3 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36801.2 - 4.8e-10 39.2 0.0 8.6e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.1 EDK36802.2 - 5.5e-13 48.5 6.7 9.1e-13 47.8 4.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EDK36802.2 - 2.2e-06 27.6 3.3 4.7e-06 26.6 2.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EDK36802.2 - 2.7e-06 27.3 6.9 4.2e-06 26.6 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK36802.2 - 6.4e-06 25.7 5.3 1.1e-05 25.0 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK36802.2 - 9.9e-06 25.1 4.9 1.6e-05 24.5 3.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 EDK36802.2 - 8.6e-05 22.3 2.4 0.00016 21.4 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 EDK36802.2 - 0.00041 19.9 3.9 0.00064 19.3 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.1 EDK36802.2 - 0.001 18.7 6.0 0.0032 17.1 4.1 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.1 EDK36802.2 - 0.016 14.8 4.1 0.038 13.6 2.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.24 EDK36802.2 - 0.017 14.8 5.7 0.028 14.1 4.0 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.1 EDK36802.2 - 0.09 12.3 6.1 0.16 11.6 4.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain BSD PF03909.12 EDK36802.2 - 0.13 11.9 0.0 0.34 10.6 0.0 1.7 1 0 0 1 1 1 0 BSD domain RINGv PF12906.2 EDK36802.2 - 0.21 11.6 7.0 0.36 10.9 4.9 1.4 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.1 EDK36802.2 - 1.1 9.2 6.0 2 8.3 4.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING HemY_N PF07219.8 EDK36802.2 - 9.3 5.8 6.1 0.49 9.9 0.1 1.9 2 0 0 2 2 1 0 HemY protein N-terminus eIF-5a PF01287.15 EDK36803.1 - 9.3e-30 102.3 0.7 1.4e-29 101.8 0.5 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 EDK36803.1 - 0.0007 19.2 0.5 0.0015 18.2 0.3 1.5 1 0 0 1 1 1 1 KOW motif TcdB_toxin_midN PF12256.3 EDK36803.1 - 0.00076 18.9 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Insecticide toxin TcdB middle/N-terminal region EFP_N PF08207.7 EDK36803.1 - 0.028 14.2 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain PWWP PF00855.12 EDK36804.2 - 1.1e-17 63.9 0.1 2.5e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 PWWP domain Med26 PF08711.6 EDK36804.2 - 0.00088 18.7 0.1 0.002 17.5 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Profilin PF00235.14 EDK36804.2 - 0.092 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Profilin Daxx PF03344.10 EDK36804.2 - 0.099 11.1 27.9 0.18 10.2 19.3 1.4 1 1 0 1 1 1 0 Daxx Family SDA1 PF05285.7 EDK36804.2 - 0.18 11.0 18.6 0.35 10.1 12.9 1.6 1 0 0 1 1 1 0 SDA1 Colicin_im PF03857.8 EDK36806.2 - 0.0016 18.2 0.7 0.0031 17.2 0.5 1.5 1 0 0 1 1 1 1 Colicin immunity protein DNA_pol_A PF00476.15 EDK36807.2 - 4.8e-92 308.5 0.0 6.6e-92 308.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A MFS_1 PF07690.11 EDK36808.2 - 9.3e-26 90.3 20.7 9.5e-20 70.5 3.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36808.2 - 7e-07 28.1 9.7 7e-07 28.1 6.7 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.1 EDK36808.2 - 0.00028 19.4 23.6 0.00042 18.8 6.3 3.0 2 1 2 4 4 4 2 MFS/sugar transport protein UNC-93 PF05978.11 EDK36808.2 - 0.004 16.6 3.7 0.004 16.6 2.5 3.0 3 1 1 4 4 4 1 Ion channel regulatory protein UNC-93 FMN_red PF03358.10 EDK36808.2 - 0.02 14.3 0.0 0.042 13.3 0.0 1.5 1 0 0 1 1 1 0 NADPH-dependent FMN reductase Bacteriocin_II PF01721.13 EDK36808.2 - 0.051 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Class II bacteriocin zf-H2C2_2 PF13465.1 EDK36810.2 - 4.7e-05 23.4 15.7 0.00017 21.7 4.0 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 EDK36810.2 - 0.00014 22.0 17.0 0.072 13.4 4.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK36810.2 - 0.0092 16.2 21.2 0.25 11.7 5.4 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger BAF1_ABF1 PF04684.8 EDK36811.2 - 0.031 13.1 4.1 0.043 12.6 2.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.11 EDK36811.2 - 0.078 12.8 2.0 0.1 12.4 1.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMF_DNA_bd PF12329.3 EDK36811.2 - 0.12 12.2 3.5 4.6 7.1 0.5 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Zip PF02535.17 EDK36811.2 - 0.25 10.3 6.6 0.3 10.0 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter P5-ATPase PF12409.3 EDK36811.2 - 0.39 10.5 1.9 0.84 9.5 1.3 1.7 1 0 0 1 1 1 0 P5-type ATPase cation transporter RTBV_P12 PF06361.6 EDK36811.2 - 1.3 9.2 6.4 0.48 10.6 1.8 2.3 3 1 0 3 3 3 0 Rice tungro bacilliform virus P12 protein SelP_N PF04592.9 EDK36811.2 - 1.6 8.0 9.9 2.7 7.3 6.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Trypsin_2 PF13365.1 EDK36812.2 - 3.1e-09 36.8 0.0 1.3e-08 34.8 0.0 2.0 2 1 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.21 EDK36812.2 - 0.00017 21.2 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Trypsin zf-BED PF02892.10 EDK36813.2 - 7.8e-08 31.9 0.3 1.8e-07 30.8 0.2 1.6 1 0 0 1 1 1 1 BED zinc finger DUF4109 PF13397.1 EDK36813.2 - 0.0029 17.9 0.1 0.0085 16.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4109) PyrI_C PF02748.10 EDK36813.2 - 0.042 13.2 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Arc_trans_TRASH PF08394.5 EDK36813.2 - 0.11 12.6 0.4 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Archaeal TRASH domain Pkinase PF00069.20 EDK36815.2 - 9.8e-57 192.0 10.1 1.5e-39 135.6 0.1 3.2 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36815.2 - 1.5e-24 86.4 9.4 1.4e-20 73.4 0.0 3.0 2 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.18 EDK36815.2 - 0.12 12.1 12.5 0.87 9.2 0.1 3.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Ytp1 PF10355.4 EDK36816.2 - 1.5e-107 358.8 9.0 1.5e-107 358.8 6.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EDK36816.2 - 3.5e-36 122.9 8.8 3.5e-36 122.9 6.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) S-methyl_trans PF02574.11 EDK36817.2 - 1.9e-49 168.5 0.0 2.7e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase MIF4G_like PF09088.6 EDK36818.2 - 2.7e-71 238.9 1.9 6.6e-71 237.6 1.3 1.7 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 EDK36818.2 - 1.4e-50 171.8 2.7 2.9e-50 170.8 1.9 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.14 EDK36818.2 - 2.6e-09 36.8 7.1 5.1e-09 35.8 1.6 2.8 3 0 0 3 3 3 1 MIF4G domain ABC_tran PF00005.22 EDK36819.2 - 2e-15 57.2 0.0 5.8e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EDK36819.2 - 5e-14 52.9 3.6 1.1e-05 25.5 0.0 3.0 2 1 1 3 3 3 2 AAA domain SMC_N PF02463.14 EDK36819.2 - 3e-05 23.3 0.1 0.16 11.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 EDK36819.2 - 0.00023 20.3 0.0 0.33 9.9 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 EDK36819.2 - 0.00085 18.7 0.1 0.0017 17.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EDK36819.2 - 0.0014 19.0 0.3 0.0039 17.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EDK36819.2 - 0.0031 16.7 0.0 0.0047 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 EDK36819.2 - 0.004 16.6 0.2 0.02 14.3 0.0 1.9 1 1 0 2 2 2 1 AAA-like domain AAA PF00004.24 EDK36819.2 - 0.004 17.3 0.0 0.036 14.2 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MutS_V PF00488.16 EDK36819.2 - 0.012 15.0 0.0 0.029 13.7 0.0 1.6 2 0 0 2 2 2 0 MutS domain V AAA_13 PF13166.1 EDK36819.2 - 0.017 13.6 0.0 0.023 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EDK36819.2 - 0.024 15.4 3.9 0.11 13.2 2.7 2.3 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EDK36819.2 - 0.026 13.9 0.2 0.12 11.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EDK36819.2 - 0.029 14.6 0.1 0.078 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 EDK36819.2 - 0.031 13.9 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.1 EDK36819.2 - 0.067 13.1 0.7 0.19 11.6 0.5 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 EDK36819.2 - 0.077 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EDK36819.2 - 0.081 13.0 0.2 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 EDK36819.2 - 0.089 12.4 0.2 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NDK PF00334.14 EDK36820.1 - 5.2e-53 178.4 0.0 5.9e-53 178.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase WD40 PF00400.27 EDK36821.1 - 3.8e-14 51.9 17.6 3.5e-06 26.6 0.1 6.8 6 1 0 6 6 6 4 WD domain, G-beta repeat RabGAP-TBC PF00566.13 EDK36822.2 - 2.8e-24 85.7 3.2 5.4e-24 84.8 2.2 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TauD PF02668.11 EDK36823.2 - 1.7e-40 139.3 0.0 2.8e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 EDK36823.2 - 3.5e-07 30.5 0.6 4.7e-05 23.7 0.0 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF971) 2OG-FeII_Oxy_3 PF13640.1 EDK36823.2 - 0.067 13.7 0.1 0.21 12.1 0.0 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Aldo_ket_red PF00248.16 EDK36824.1 - 3.5e-57 193.3 0.0 4.1e-57 193.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Reo_sigmaC PF04582.7 EDK36825.2 - 6.3e-11 42.0 35.0 4.8e-09 35.8 3.2 4.2 1 1 3 4 4 4 3 Reovirus sigma C capsid protein HOOK PF05622.7 EDK36825.2 - 3e-05 22.0 57.7 5.1e-05 21.2 40.0 1.3 1 0 0 1 1 1 1 HOOK protein AAA_13 PF13166.1 EDK36825.2 - 0.00021 19.9 22.0 0.00021 19.9 15.2 4.3 2 1 1 4 4 4 1 AAA domain IncA PF04156.9 EDK36825.2 - 0.00023 20.8 13.8 0.00023 20.8 9.6 5.3 1 1 4 5 5 5 2 IncA protein AAA_22 PF13401.1 EDK36825.2 - 0.0004 20.5 0.1 0.0075 16.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain Fib_alpha PF08702.5 EDK36825.2 - 0.00098 19.2 8.3 0.00098 19.2 5.8 6.1 2 1 5 7 7 6 1 Fibrinogen alpha/beta chain family AAA_33 PF13671.1 EDK36825.2 - 0.0037 17.1 0.1 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 EDK36825.2 - 0.018 14.7 1.2 0.12 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 EDK36825.2 - 0.02 15.2 0.0 0.02 15.2 0.0 4.9 2 1 0 2 2 1 0 ABC transporter CENP-F_leu_zip PF10473.4 EDK36825.2 - 0.026 14.4 86.0 0.93 9.3 12.5 6.5 1 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.6 EDK36825.2 - 0.028 14.2 74.7 0.11 12.3 11.8 7.0 1 1 6 7 7 7 0 Autophagy protein 16 (ATG16) DUF948 PF06103.6 EDK36825.2 - 0.028 14.2 38.5 0.076 12.8 0.8 6.6 2 1 4 7 7 7 0 Bacterial protein of unknown function (DUF948) AAA_29 PF13555.1 EDK36825.2 - 0.031 13.7 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain BLOC1_2 PF10046.4 EDK36825.2 - 0.14 12.2 53.1 0.026 14.6 1.7 6.2 2 2 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Bacillus_HBL PF05791.6 EDK36825.2 - 0.29 10.5 52.4 0.048 13.0 2.6 6.0 2 1 4 6 6 6 0 Bacillus haemolytic enterotoxin (HBL) AAA_10 PF12846.2 EDK36825.2 - 0.34 10.3 10.2 0.36 10.2 0.0 3.1 3 0 0 3 3 3 0 AAA-like domain DUF1664 PF07889.7 EDK36825.2 - 0.54 10.0 49.4 0.49 10.1 1.1 6.1 1 1 6 7 7 7 0 Protein of unknown function (DUF1664) FtsK_SpoIIIE PF01580.13 EDK36825.2 - 0.64 9.4 6.2 1.3 8.4 0.0 3.4 3 1 0 3 3 3 0 FtsK/SpoIIIE family AAA_16 PF13191.1 EDK36825.2 - 0.82 9.6 0.0 0.82 9.6 0.0 3.5 3 2 0 3 3 3 0 AAA ATPase domain WXG100 PF06013.7 EDK36825.2 - 1.5 8.8 19.1 6.8 6.7 0.1 6.3 5 2 1 6 6 5 0 Proteins of 100 residues with WXG DUF2852 PF11014.3 EDK36825.2 - 2.1 8.3 6.2 0.5 10.3 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) Atg14 PF10186.4 EDK36825.2 - 3.3 6.5 66.1 0.015 14.2 7.1 4.3 1 1 3 4 4 4 0 UV radiation resistance protein and autophagy-related subunit 14 Filament PF00038.16 EDK36825.2 - 3.4 7.0 68.8 0.012 15.0 20.4 4.2 2 1 0 3 3 2 0 Intermediate filament protein TBPIP PF07106.8 EDK36825.2 - 3.5 7.1 77.2 0.073 12.6 5.4 6.2 2 1 3 6 6 6 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.6 EDK36825.2 - 3.5 6.1 77.2 0.47 9.0 10.4 4.8 1 1 4 5 5 5 0 Spc7 kinetochore protein V_ATPase_I PF01496.14 EDK36825.2 - 3.7 5.2 56.2 2.2 5.9 22.3 3.3 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family CALCOCO1 PF07888.6 EDK36825.2 - 6.2 4.9 67.7 0.18 10.0 2.5 4.2 1 1 3 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like P16-Arc PF04699.9 EDK36826.2 - 1.6e-56 190.5 0.0 1.8e-56 190.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) RNA_binding PF01877.12 EDK36826.2 - 0.084 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA binding Utp13 PF08625.6 EDK36826.2 - 0.1 12.2 0.1 0.18 11.4 0.1 1.5 1 1 0 1 1 1 0 Utp13 specific WD40 associated domain DUF1892 PF08987.5 EDK36827.2 - 1.9e-35 121.3 5.9 2e-35 121.2 4.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) DUF1857 PF08982.6 EDK36827.2 - 0.031 13.8 0.2 0.04 13.5 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1857) DUF365 PF04033.7 EDK36827.2 - 0.072 13.0 1.2 0.15 12.0 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF365) PGI PF00342.14 EDK36828.2 - 1.7e-220 732.5 1.9 1.9e-220 732.3 1.3 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Mhr1 PF12829.2 EDK36828.2 - 0.041 13.7 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulation of mitochondrial recombination IncA PF04156.9 EDK36829.2 - 6.2 6.3 6.7 12 5.3 4.6 1.5 1 0 0 1 1 1 0 IncA protein Peptidase_S64 PF08192.6 EDK36829.2 - 7.6 4.7 19.3 2.5 6.3 11.5 1.4 1 1 0 1 1 1 0 Peptidase family S64 Zn_clus PF00172.13 EDK36831.2 - 1.1e-05 25.2 10.1 2.2e-05 24.2 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease_2 PF13520.1 EDK36832.2 - 6.6e-47 159.9 56.9 8.3e-47 159.6 39.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK36832.2 - 3.7e-19 68.4 49.3 5.2e-19 67.9 34.2 1.1 1 0 0 1 1 1 1 Amino acid permease zf-RING_2 PF13639.1 EDK36833.2 - 1.5e-06 27.8 6.6 3.1e-06 26.9 4.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EDK36833.2 - 4.6e-05 23.4 2.2 8.8e-05 22.5 1.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK36833.2 - 5.1e-05 22.9 7.7 0.00017 21.2 5.4 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK36833.2 - 0.00016 21.2 4.6 0.00043 19.9 3.2 1.7 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK36833.2 - 0.00075 19.1 4.4 0.0021 17.6 3.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK36833.2 - 0.019 14.9 2.0 0.019 14.9 1.4 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1811 PF08838.5 EDK36833.2 - 0.071 13.0 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) zf-RING_UBOX PF13445.1 EDK36833.2 - 0.071 12.8 2.1 0.2 11.3 1.5 1.8 1 1 0 1 1 1 0 RING-type zinc-finger DUF2975 PF11188.3 EDK36833.2 - 9.6 5.9 8.5 4.2 7.0 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) Glypican PF01153.14 EDK36836.2 - 0.15 10.6 0.3 0.21 10.1 0.2 1.2 1 0 0 1 1 1 0 Glypican Pol_alpha_B_N PF08418.5 EDK36836.2 - 0.21 11.0 6.3 0.3 10.5 4.3 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal TMV_coat PF00721.16 EDK36836.2 - 2.5 8.0 7.6 7.8 6.4 0.4 2.3 1 1 1 2 2 2 0 Virus coat protein (TMV like) Macoilin PF09726.4 EDK36836.2 - 3.4 5.8 16.7 3.9 5.6 11.6 1.0 1 0 0 1 1 1 0 Transmembrane protein Cation_efflux PF01545.16 EDK36837.2 - 2.4e-35 122.0 12.5 3e-35 121.6 8.7 1.1 1 0 0 1 1 1 1 Cation efflux family WD40 PF00400.27 EDK36838.1 - 6.6e-26 89.2 8.8 2.7e-09 36.5 0.0 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat Gmad1 PF10647.4 EDK36838.1 - 0.00012 21.5 0.2 0.00074 18.9 0.0 2.2 2 0 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain DUF3312 PF11768.3 EDK36838.1 - 0.0052 15.0 0.0 0.01 14.0 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3312) Rax2 PF12768.2 EDK36838.1 - 0.0074 15.5 0.0 0.019 14.2 0.0 1.6 2 0 0 2 2 2 1 Cortical protein marker for cell polarity PD40 PF07676.7 EDK36838.1 - 0.021 14.4 0.8 14 5.5 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat eIF2A PF08662.6 EDK36838.1 - 0.067 12.8 0.0 0.79 9.3 0.0 2.3 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 EDK36838.1 - 0.073 12.5 0.0 2.5 7.6 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.16 EDK36838.1 - 0.15 10.6 0.5 4.9 5.6 0.3 2.9 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DASH_Dad3 PF08656.5 EDK36840.2 - 7.4e-31 105.6 0.2 9.7e-31 105.2 0.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 COG6 PF06419.6 EDK36840.2 - 0.011 13.9 0.1 0.011 13.8 0.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Lyase_1 PF00206.15 EDK36841.1 - 8.2e-22 77.7 0.0 1.4e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 EDK36841.1 - 3.8e-16 58.8 0.0 2.3e-15 56.3 0.0 2.3 3 0 0 3 3 3 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.6 EDK36841.1 - 0.035 13.5 0.0 0.072 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) AsiA PF09010.5 EDK36841.1 - 0.064 13.1 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Anti-Sigma Factor A Mid2 PF04478.7 EDK36843.2 - 1.1e-07 31.3 1.9 1.1e-07 31.3 1.3 3.0 2 1 2 4 4 4 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 EDK36843.2 - 8.9e-05 21.7 1.4 8.9e-05 21.7 1.0 2.6 2 0 0 2 2 2 1 Transmembrane alpha-helix domain CytochromB561_N PF09786.4 EDK36843.2 - 1.7 6.9 17.0 1.9 6.8 11.8 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal ATG22 PF11700.3 EDK36843.2 - 2.9 6.2 7.2 5.5 5.3 5.0 1.7 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like TATR PF03430.8 EDK36843.2 - 5.6 5.4 12.8 7 5.1 8.8 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator DUF605 PF04652.11 EDK36843.2 - 6.5 6.0 21.1 9.1 5.5 14.6 1.1 1 0 0 1 1 1 0 Vta1 like DNA_pol_viral_N PF00242.12 EDK36843.2 - 6.7 5.6 17.2 8.3 5.3 11.9 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Borrelia_P83 PF05262.6 EDK36844.1 - 0.00058 18.2 31.1 0.00069 18.0 21.6 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein MIP-T3 PF10243.4 EDK36844.1 - 0.12 10.8 53.0 0.18 10.2 36.8 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NAD_binding_10 PF13460.1 EDK36845.2 - 1.5e-11 44.6 0.0 8.6e-11 42.1 0.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK36845.2 - 5.7e-09 35.7 0.0 2.4e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK36845.2 - 1.2e-07 30.6 0.0 1.6e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EDK36845.2 - 0.00045 19.2 0.5 0.0028 16.5 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein adh_short PF00106.20 EDK36845.2 - 0.039 13.8 0.0 0.077 12.9 0.0 1.5 1 1 0 1 1 1 0 short chain dehydrogenase RmlD_sub_bind PF04321.12 EDK36845.2 - 0.12 11.2 0.0 0.36 9.6 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short_C2 PF13561.1 EDK36845.2 - 0.15 11.8 0.1 4.2 7.0 0.0 2.1 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase HPP PF04982.8 EDK36846.2 - 1.8e-38 131.0 8.2 3.1e-38 130.2 5.7 1.4 1 0 0 1 1 1 1 HPP family E1-E2_ATPase PF00122.15 EDK36847.2 - 7.1e-79 264.0 0.9 1.5e-78 262.9 0.6 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EDK36847.2 - 2.5e-45 154.2 0.4 2.5e-45 154.2 0.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EDK36847.2 - 2.5e-35 122.8 0.0 9.3e-35 120.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK36847.2 - 3e-14 53.6 0.0 7.4e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EDK36847.2 - 5.2e-14 51.4 0.0 1.2e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 EDK36847.2 - 3.2e-13 49.4 0.0 7.4e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EDK36847.2 - 2.2e-09 37.2 1.4 2.4e-06 27.3 1.4 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase RseC_MucC PF04246.7 EDK36847.2 - 0.089 12.3 0.0 0.43 10.1 0.0 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Sua5_yciO_yrdC PF01300.13 EDK36848.2 - 3.2e-51 173.0 0.0 5.6e-51 172.3 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 EDK36848.2 - 5.8e-34 116.8 0.0 8.6e-34 116.3 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Xpo1 PF08389.7 EDK36849.2 - 2.1e-05 24.4 6.1 0.036 13.9 0.0 5.8 3 1 2 5 5 5 2 Exportin 1-like protein IBN_N PF03810.14 EDK36849.2 - 0.028 14.3 0.6 0.34 10.8 0.0 3.3 4 1 0 4 4 4 0 Importin-beta N-terminal domain VacA PF02691.10 EDK36849.2 - 0.08 10.5 0.0 0.19 9.3 0.0 1.5 2 0 0 2 2 2 0 Vacuolating cyotoxin Fis1_TPR_C PF14853.1 EDK36850.2 - 1.6e-26 91.9 0.3 2.8e-26 91.1 0.2 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 EDK36850.2 - 5.8e-14 51.0 0.0 2.1e-13 49.3 0.0 1.9 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_16 PF13432.1 EDK36850.2 - 2e-05 25.1 2.6 0.0099 16.5 0.2 2.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 EDK36850.2 - 0.00024 20.7 1.0 0.00053 19.6 0.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK36850.2 - 0.00035 20.8 0.5 0.00035 20.8 0.4 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK36850.2 - 0.0026 18.1 0.4 0.013 15.9 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36850.2 - 0.0036 17.7 0.1 0.02 15.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 EDK36850.2 - 0.097 12.9 0.2 0.21 11.8 0.1 1.5 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_7 PF13176.1 EDK36850.2 - 0.22 11.3 1.0 1.7 8.6 0.1 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat A_deamin PF02137.13 EDK36851.2 - 3.2e-65 220.6 0.0 4.4e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank PF00023.25 EDK36852.2 - 1.6e-14 52.8 0.2 5e-07 29.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 EDK36852.2 - 5e-11 42.8 0.3 5.2e-10 39.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK36852.2 - 5.7e-10 39.4 0.3 2.6e-06 27.7 0.0 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 EDK36852.2 - 2.4e-09 37.1 0.1 5e-05 23.4 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK36852.2 - 8.8e-09 34.7 0.0 0.0056 16.7 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ribul_P_3_epim PF00834.14 EDK36853.2 - 9.8e-72 240.2 0.0 1.2e-71 240.0 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.9 EDK36853.2 - 0.00038 19.6 0.4 0.00055 19.0 0.3 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG PcrB PF01884.12 EDK36853.2 - 0.001 18.3 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 PcrB family OMPdecase PF00215.19 EDK36853.2 - 0.0067 15.8 0.2 0.015 14.7 0.1 1.5 1 1 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family PG_binding_3 PF09374.5 EDK36853.2 - 0.036 14.0 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Predicted Peptidoglycan domain QRPTase_C PF01729.14 EDK36853.2 - 0.094 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Alb1 PF09135.6 EDK36854.1 - 6.1e-19 68.6 14.0 6.1e-19 68.6 9.7 1.4 1 1 0 1 1 1 1 Alb1 Macoilin PF09726.4 EDK36854.1 - 0.71 8.0 9.6 0.85 7.8 6.7 1.0 1 0 0 1 1 1 0 Transmembrane protein Peptidase_M28 PF04389.12 EDK36855.2 - 4.1e-17 62.4 0.0 7.5e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.10 EDK36855.2 - 1.1e-15 57.3 0.4 2.7e-15 56.0 0.3 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 EDK36855.2 - 1.2e-07 31.2 0.3 3.3e-07 29.9 0.2 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EDK36855.2 - 0.0046 16.4 0.0 0.0085 15.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 zf-rbx1 PF12678.2 EDK36856.2 - 0.015 15.3 0.2 0.046 13.8 0.1 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 EDK36856.2 - 0.16 11.8 9.0 0.067 13.0 3.9 2.1 2 0 0 2 2 2 0 Ring finger domain Macoilin PF09726.4 EDK36857.1 - 0.61 8.3 19.8 0.74 8.0 13.7 1.0 1 0 0 1 1 1 0 Transmembrane protein Telomere_reg-2 PF10193.4 EDK36858.2 - 1e-30 106.3 0.6 4.6e-30 104.1 0.1 2.4 2 0 0 2 2 2 1 Telomere length regulation protein DNA_pol_A_exo1 PF01612.15 EDK36859.2 - 0.00048 19.6 0.0 0.0016 17.9 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease AP_endonuc_2 PF01261.19 EDK36860.2 - 6.8e-29 100.6 0.0 1e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Nucleoporin2 PF04096.9 EDK36861.2 - 1.4e-47 161.0 0.0 2.1e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 EDK36861.2 - 6.3e-36 123.0 400.1 3.9e-08 33.5 32.7 10.0 3 2 6 9 9 9 7 Nucleoporin FG repeat region XPG_I PF00867.13 EDK36862.2 - 5e-27 93.7 0.2 1e-26 92.7 0.1 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EDK36862.2 - 1.8e-18 66.6 0.0 3.4e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 EDK36862.2 - 1.5e-06 28.3 0.0 7.3e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.2 EDK36862.2 - 0.064 13.1 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Proteasome PF00227.21 EDK36863.2 - 2.5e-58 196.5 0.1 3.1e-58 196.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF3647 PF12363.3 EDK36863.2 - 0.058 13.4 1.7 3 7.9 0.0 2.4 1 1 1 2 2 2 0 Phage protein FumaraseC_C PF10415.4 EDK36864.2 - 2e-25 88.6 0.0 3.6e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Fumarase C C-terminus Lyase_1 PF00206.15 EDK36864.2 - 9.5e-13 48.0 1.0 1.6e-12 47.2 0.7 1.3 1 0 0 1 1 1 1 Lyase DUF1153 PF06627.6 EDK36864.2 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) C6 PF01681.12 EDK36864.2 - 0.15 12.1 2.1 0.29 11.2 0.7 2.0 1 1 1 2 2 2 0 C6 domain Lyase_1 PF00206.15 EDK36865.1 - 4.8e-98 328.1 0.0 5.8e-98 327.9 0.0 1.0 1 0 0 1 1 1 1 Lyase TOM13 PF08219.6 EDK36866.2 - 4.2e-32 109.7 0.0 7.2e-32 108.9 0.0 1.4 1 0 0 1 1 1 1 Outer membrane protein TOM13 STAT2_C PF12188.3 EDK36866.2 - 0.19 11.5 0.9 0.48 10.2 0.2 1.9 2 0 0 2 2 2 0 Signal transducer and activator of transcription 2 C terminal Hexokinase_2 PF03727.11 EDK36867.2 - 7.8e-93 310.1 0.0 1.1e-92 309.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EDK36867.2 - 1.8e-82 275.6 0.0 3e-82 274.9 0.0 1.4 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.16 EDK36867.2 - 0.15 11.3 0.0 0.46 9.7 0.0 1.7 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain GPI2 PF06432.6 EDK36869.2 - 8.7e-89 297.5 13.3 9.8e-89 297.4 9.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF4235 PF14019.1 EDK36869.2 - 0.053 13.3 1.8 0.084 12.7 1.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4235) Peptidase_M56 PF05569.6 EDK36869.2 - 0.56 9.1 7.7 0.061 12.2 0.6 2.3 2 1 1 3 3 3 0 BlaR1 peptidase M56 H_PPase PF03030.11 EDK36869.2 - 0.69 8.1 5.7 1.5 7.0 3.9 1.5 1 1 0 1 1 1 0 Inorganic H+ pyrophosphatase WD40 PF00400.27 EDK36870.2 - 1.5e-66 218.0 19.3 8.3e-13 47.6 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 EDK36870.2 - 1.3e-49 167.9 0.0 2.3e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit Nup160 PF11715.3 EDK36870.2 - 1e-06 27.2 1.8 0.047 11.8 0.0 4.0 2 2 1 4 4 4 2 Nucleoporin Nup120/160 LisH PF08513.6 EDK36870.2 - 1.3e-06 27.9 0.1 2.7e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 LisH eIF2A PF08662.6 EDK36870.2 - 1.6e-06 27.9 0.6 0.0012 18.5 0.0 3.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A p47_phox_C PF08944.6 EDK36870.2 - 0.0026 17.9 3.0 0.0059 16.7 2.1 1.5 1 0 0 1 1 1 1 NADPH oxidase subunit p47Phox, C terminal domain TrpBP PF02081.10 EDK36870.2 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein DUF572 PF04502.8 EDK36871.1 - 1.1 8.4 4.3 1.2 8.2 3.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) SpoIIIAH PF12685.2 EDK36871.1 - 1.5 8.3 10.9 1.9 7.9 7.6 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CDC27 PF09507.5 EDK36871.1 - 3.9 6.5 10.1 4.5 6.3 7.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DNA_pol_viral_N PF00242.12 EDK36871.1 - 5.7 5.8 8.9 6.4 5.6 6.2 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain SRP1_TIP1 PF00660.12 EDK36872.1 - 5.2e-17 61.5 0.2 6.9e-17 61.1 0.1 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family DUF515 PF04415.7 EDK36872.1 - 0.37 8.9 3.4 0.43 8.7 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Folliculin PF11704.3 EDK36873.2 - 7.1e-53 178.6 0.3 2.4e-52 176.8 0.0 1.8 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport Atg14 PF10186.4 EDK36874.2 - 1.5e-11 43.8 3.8 3.2e-11 42.7 0.5 2.4 2 1 1 3 3 3 1 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 EDK36874.2 - 0.0013 17.8 0.0 0.0013 17.8 0.0 2.3 2 1 1 3 3 3 1 Autophagy protein Apg6 AAA_14 PF13173.1 EDK36874.2 - 0.07 13.0 2.8 0.063 13.1 0.4 2.0 2 0 0 2 2 2 0 AAA domain DUF462 PF04315.7 EDK36874.2 - 0.071 12.4 0.3 6 6.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function, DUF462 LicD PF04991.8 EDK36875.2 - 1.7e-46 158.9 1.1 2.7e-46 158.2 0.8 1.3 1 0 0 1 1 1 1 LicD family Peptidase_S24 PF00717.18 EDK36876.1 - 2.3e-11 43.1 0.3 8.7e-11 41.3 0.2 1.9 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 EDK36876.1 - 5.8e-06 25.8 0.0 0.00075 19.0 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 CHCH PF06747.8 EDK36877.1 - 2e-06 27.5 3.3 0.016 15.1 0.1 3.1 2 1 0 2 2 2 2 CHCH domain COX17 PF05051.8 EDK36877.1 - 0.057 13.4 1.0 5.2 7.1 0.0 2.5 2 1 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) CagY_M PF07337.6 EDK36877.1 - 0.099 12.1 1.8 0.18 11.2 1.3 1.5 1 0 0 1 1 1 0 DC-EC Repeat COX6B PF02297.12 EDK36877.1 - 0.25 11.3 3.5 2.7 8.0 2.4 2.2 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb GCK PF07802.6 EDK36877.1 - 0.31 11.1 4.5 6.7 6.9 0.6 2.3 1 1 2 3 3 3 0 GCK domain Pet191_N PF10203.4 EDK36877.1 - 0.71 9.9 5.6 2.1 8.4 0.6 2.4 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 EDK36877.1 - 0.85 9.4 4.3 1.7 8.4 1.9 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like EF-hand_1 PF00036.27 EDK36878.2 - 1.1e-05 24.3 0.0 2.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 EDK36878.2 - 1.5e-05 24.9 0.6 3.6e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 EDK36878.2 - 4.1e-05 22.7 0.0 8.4e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 EDK36878.2 - 7.4e-05 22.2 0.0 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 EDK36878.2 - 0.0018 17.9 0.0 0.01 15.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain NUDIX PF00293.23 EDK36879.2 - 2e-14 53.3 0.0 2.7e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.8 EDK36880.1 - 8.2e-36 123.8 1.8 1.5e-35 123.0 1.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF410) TPR_20 PF14561.1 EDK36880.1 - 0.034 14.2 0.4 0.094 12.8 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat LAP2alpha PF11560.3 EDK36880.1 - 0.13 11.4 1.5 0.22 10.6 1.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha Proteasome PF00227.21 EDK36881.2 - 4.4e-27 94.5 0.0 5.7e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Phytase PF02333.10 EDK36881.2 - 0.014 14.1 0.1 0.022 13.5 0.1 1.3 1 0 0 1 1 1 0 Phytase PDEase_II PF02112.10 EDK36882.2 - 4.5e-72 242.8 3.5 5.5e-72 242.5 2.4 1.0 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 EDK36882.2 - 7.1e-08 32.2 0.1 1e-07 31.6 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Adap_comp_sub PF00928.16 EDK36883.2 - 1.4e-10 40.7 0.0 2.3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EDK36883.2 - 3.9e-09 36.3 0.1 6.8e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.4 EDK36883.2 - 0.0089 15.2 0.6 0.032 13.4 0.0 2.1 2 1 0 2 2 2 1 Muniscin C-terminal mu homology domain Shufflon_N PF04917.7 EDK36883.2 - 0.11 11.5 0.0 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial shufflon protein, N-terminal constant region TPR_12 PF13424.1 EDK36885.2 - 2.5e-07 30.5 3.7 0.0093 15.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EDK36885.2 - 0.0017 19.0 0.2 0.013 16.1 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK36885.2 - 0.0038 17.7 1.1 0.62 10.8 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 EDK36885.2 - 0.0098 15.4 11.5 0.079 12.5 0.0 3.8 5 0 0 5 5 4 2 Tetratricopeptide repeat DUF2225 PF09986.4 EDK36885.2 - 0.021 14.2 1.0 0.035 13.5 0.0 1.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Foie-gras_1 PF11817.3 EDK36885.2 - 0.03 13.8 2.9 0.036 13.5 0.2 2.0 2 0 0 2 2 2 0 Foie gras liver health family 1 TPR_7 PF13176.1 EDK36885.2 - 0.037 13.8 2.5 1.9 8.4 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 EDK36885.2 - 0.047 13.6 9.4 0.09 12.7 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat Apc3 PF12895.2 EDK36885.2 - 0.14 12.3 0.0 0.14 12.3 0.0 3.5 4 1 1 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 EDK36885.2 - 0.15 12.4 3.5 0.54 10.6 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat UBN2 PF14223.1 EDK36885.2 - 0.15 11.8 2.3 0.99 9.2 0.4 2.2 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type TPR_10 PF13374.1 EDK36885.2 - 0.17 11.8 2.7 0.49 10.3 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 EDK36885.2 - 0.24 11.0 8.3 0.66 9.6 0.1 3.6 3 2 0 3 3 3 0 TPR repeat MIT PF04212.13 EDK36885.2 - 0.26 11.1 2.8 0.94 9.3 0.1 2.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain COG4 PF08318.7 EDK36886.2 - 1.5e-66 224.4 0.1 2.4e-66 223.8 0.1 1.3 1 0 0 1 1 1 1 COG4 transport protein zf-CCCH PF00642.19 EDK36887.2 - 1.4e-14 53.3 28.7 0.0035 16.9 0.7 5.8 5 1 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EDK36887.2 - 0.0047 16.8 46.4 0.45 10.6 4.0 7.0 6 2 1 7 7 7 4 Zinc finger C-x8-C-x5-C-x3-H type Spo7 PF03907.8 EDK36888.2 - 1.2e-73 247.1 4.7 1.5e-73 246.8 3.3 1.1 1 0 0 1 1 1 1 Spo7-like protein GWT1 PF06423.7 EDK36889.2 - 2.9e-41 140.7 7.0 2.9e-41 140.7 4.9 2.6 2 0 0 2 2 2 1 GWT1 Oxysterol_BP PF01237.13 EDK36890.2 - 6.2e-90 301.2 0.2 7.2e-90 301.0 0.1 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Ribosomal_L35Ae PF01247.13 EDK36891.2 - 1.3e-39 133.8 1.1 1.4e-39 133.7 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 EDK36891.2 - 0.029 14.2 0.0 5.3 7.0 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain GAS PF13851.1 EDK36892.2 - 7.8e-06 25.2 58.5 0.00069 18.8 14.4 3.9 1 1 2 4 4 4 2 Growth-arrest specific micro-tubule binding GRAB PF10375.4 EDK36892.2 - 6.7e-05 22.3 0.2 0.00018 21.0 0.1 1.8 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Reo_sigmaC PF04582.7 EDK36892.2 - 0.0009 18.5 26.1 0.03 13.5 6.0 3.4 1 1 3 4 4 4 3 Reovirus sigma C capsid protein TBPIP PF07106.8 EDK36892.2 - 0.0018 17.8 16.9 0.0018 17.8 11.7 4.7 1 1 4 5 5 5 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tropomyosin PF00261.15 EDK36892.2 - 0.0026 16.9 60.3 0.14 11.2 1.8 2.9 2 1 1 3 3 3 2 Tropomyosin EzrA PF06160.7 EDK36892.2 - 0.0026 16.0 44.4 0.0059 14.8 30.6 1.7 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA IncA PF04156.9 EDK36892.2 - 0.0097 15.5 61.3 0.11 12.1 14.5 3.4 1 1 2 3 3 3 2 IncA protein Filament PF00038.16 EDK36892.2 - 0.01 15.3 14.9 0.01 15.3 10.3 4.0 1 1 3 4 4 4 2 Intermediate filament protein ADIP PF11559.3 EDK36892.2 - 0.011 15.6 18.6 0.011 15.6 12.9 5.0 1 1 3 4 4 3 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 EDK36892.2 - 0.018 15.3 11.1 0.018 15.3 7.7 5.9 1 1 5 6 6 5 0 Protein of unknown function (DUF972) Myosin_tail_1 PF01576.14 EDK36892.2 - 0.055 11.2 61.6 0.63 7.6 42.7 2.0 1 1 0 1 1 1 0 Myosin tail AAA_13 PF13166.1 EDK36892.2 - 0.096 11.1 56.1 0.035 12.5 20.7 2.2 1 1 1 2 2 2 0 AAA domain TMF_DNA_bd PF12329.3 EDK36892.2 - 0.35 10.7 70.8 0.037 13.8 9.2 7.4 1 1 6 7 7 7 0 TATA element modulatory factor 1 DNA binding MCPsignal PF00015.16 EDK36892.2 - 0.36 10.3 33.3 0.24 10.8 6.0 3.2 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF869 PF05911.6 EDK36892.2 - 0.49 8.5 54.9 0.09 11.0 33.8 1.9 1 1 2 3 3 3 0 Plant protein of unknown function (DUF869) DUF948 PF06103.6 EDK36892.2 - 1.2 9.0 31.1 0.86 9.5 2.6 5.0 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF2120 PF09893.4 EDK36892.2 - 1.3 9.0 20.6 0.053 13.4 1.5 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) IFT57 PF10498.4 EDK36892.2 - 1.5 7.5 56.8 0.3 9.7 19.3 2.9 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.5 EDK36892.2 - 1.6 8.8 48.5 0.021 14.9 5.3 4.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Atg14 PF10186.4 EDK36892.2 - 1.9 7.3 52.7 4.1 6.2 11.8 4.1 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3584 PF12128.3 EDK36892.2 - 1.9 5.7 54.1 0.54 7.5 18.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) AAA_27 PF13514.1 EDK36892.2 - 2.6 5.6 47.4 2.7 5.5 17.1 2.4 1 1 1 2 2 2 0 AAA domain ATG16 PF08614.6 EDK36892.2 - 2.6 7.8 65.1 0.013 15.3 16.7 4.3 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) COG2 PF06148.6 EDK36892.2 - 3.1 7.6 33.2 8 6.3 1.3 4.9 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6 PF04111.7 EDK36892.2 - 4.2 6.3 64.5 0.57 9.1 6.0 4.0 1 1 3 4 4 4 0 Autophagy protein Apg6 Mod_r PF07200.8 EDK36892.2 - 4.3 7.2 48.7 5.7 6.8 14.1 4.1 2 1 2 4 4 3 0 Modifier of rudimentary (Mod(r)) protein DUF4200 PF13863.1 EDK36892.2 - 5 7.0 61.2 0.067 13.1 13.7 5.0 2 1 3 5 5 3 0 Domain of unknown function (DUF4200) Tropomyosin_1 PF12718.2 EDK36892.2 - 5.3 6.8 71.8 0.71 9.7 16.4 4.5 1 1 5 6 6 6 0 Tropomyosin like DUF1664 PF07889.7 EDK36892.2 - 6.2 6.6 36.8 3.8 7.3 2.6 4.8 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) DUF2422 PF10337.4 EDK36892.2 - 9.8 4.8 23.0 12 4.5 15.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2422) RFC1 PF08519.7 EDK36893.2 - 2.6e-57 192.9 0.1 5.2e-57 191.9 0.1 1.6 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.21 EDK36893.2 - 1.7e-12 47.3 0.0 4.3e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 EDK36893.2 - 1.7e-10 41.2 0.0 5.8e-10 39.4 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 EDK36893.2 - 1.2e-06 27.5 0.1 7.6e-06 24.8 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EDK36893.2 - 2.2e-05 24.5 1.3 0.0003 20.8 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 EDK36893.2 - 0.00011 22.2 0.0 0.00048 20.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK36893.2 - 0.00045 21.0 2.8 0.0018 19.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain PTCB-BRCT PF12738.2 EDK36893.2 - 0.0011 18.8 0.0 0.004 16.9 0.0 2.1 1 0 0 1 1 1 1 twin BRCT domain RuvB_N PF05496.7 EDK36893.2 - 0.0013 17.8 0.0 0.0023 17.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EDK36893.2 - 0.0086 15.8 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 EDK36893.2 - 0.0089 15.7 0.0 0.42 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.8 EDK36893.2 - 0.012 15.1 0.0 0.033 13.6 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RNA_helicase PF00910.17 EDK36893.2 - 0.025 14.7 0.0 0.2 11.8 0.0 2.6 2 1 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 EDK36893.2 - 0.037 13.9 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EDK36893.2 - 0.14 12.4 0.0 0.14 12.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain Pkinase PF00069.20 EDK36894.2 - 1.2e-62 211.4 0.0 1.5e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36894.2 - 3.5e-35 121.3 0.0 4.5e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36894.2 - 7.2e-10 38.2 0.0 1.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EDK36894.2 - 0.00022 20.1 0.0 0.00028 19.8 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 EDK36894.2 - 0.003 16.6 0.0 0.0047 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK36894.2 - 0.068 12.8 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nop53 PF07767.6 EDK36895.1 - 4e-31 108.3 18.9 6.2e-31 107.7 13.1 1.3 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) AKNA PF12443.3 EDK36895.1 - 0.0014 18.5 7.2 0.0023 17.9 5.0 1.4 1 0 0 1 1 1 1 AT-hook-containing transcription factor DUF3573 PF12097.3 EDK36895.1 - 0.029 12.9 4.1 0.032 12.8 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Ubiquitin_2 PF14560.1 EDK36895.1 - 0.03 14.5 2.6 0.052 13.8 1.8 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DUF4302 PF14135.1 EDK36895.1 - 0.032 13.5 2.3 0.036 13.4 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4302) Tnp_P_element PF12017.3 EDK36895.1 - 0.083 12.1 2.4 0.1 11.8 1.7 1.2 1 0 0 1 1 1 0 Transposase protein Katanin_con80 PF13925.1 EDK36895.1 - 0.18 11.5 5.0 0.26 11.0 3.4 1.3 1 0 0 1 1 1 0 con80 domain of Katanin DUF3373 PF11853.3 EDK36895.1 - 0.3 9.5 3.8 0.28 9.6 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Spt5_N PF11942.3 EDK36895.1 - 0.72 10.5 11.1 1.3 9.6 7.7 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF3153 PF11353.3 EDK36895.1 - 0.93 8.8 6.4 1.2 8.4 4.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3153) DUF4613 PF15390.1 EDK36895.1 - 1.8 6.6 7.1 2.2 6.3 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF4391 PF14335.1 EDK36895.1 - 2.4 7.4 19.7 0.82 9.0 7.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4391) DUF607 PF04678.8 EDK36895.1 - 2.5 7.9 7.1 3.7 7.4 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Spore_II_R PF09551.5 EDK36895.1 - 2.8 7.9 8.2 4.5 7.3 5.7 1.3 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) APG6 PF04111.7 EDK36895.1 - 4.1 6.3 14.5 4.9 6.1 10.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 RNA_pol_Rpb1_5 PF04998.12 EDK36895.1 - 4.4 6.4 6.5 5.5 6.1 4.5 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 HSP70 PF00012.15 EDK36895.1 - 8 4.2 12.0 9.3 4.0 8.3 1.1 1 0 0 1 1 1 0 Hsp70 protein Nop53 PF07767.6 EDK36896.1 - 6.6e-30 104.3 9.2 7.8e-30 104.1 6.4 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) S_layer_C PF05124.7 EDK36896.1 - 0.025 14.1 5.2 0.03 13.9 3.6 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region DUF2760 PF10816.3 EDK36896.1 - 0.088 12.3 0.3 0.42 10.1 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2760) chaperone_DMP PF10448.4 EDK36897.2 - 9.3e-24 83.9 0.0 1.1e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 20S proteasome chaperone RRM_1 PF00076.17 EDK36898.2 - 2.6e-06 26.9 10.1 0.00012 21.6 0.1 3.4 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2851 PF11013.3 EDK36899.2 - 0.045 12.4 0.0 0.063 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2851) Nfu_N PF08712.6 EDK36900.2 - 2.6e-29 100.6 0.1 5.1e-29 99.7 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 EDK36900.2 - 2.7e-22 78.3 0.0 4.2e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain SNF2_N PF00176.18 EDK36901.2 - 9e-64 215.1 0.3 1.4e-63 214.5 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK36901.2 - 5.1e-15 55.1 0.1 6e-13 48.4 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK36901.2 - 6.4e-10 38.7 0.0 2.4e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK36901.2 - 2.4e-09 37.2 0.0 6.4e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EDK36901.2 - 0.027 14.6 0.0 0.6 10.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain CAAP1 PF15335.1 EDK36901.2 - 0.049 13.8 0.7 0.15 12.2 0.1 2.2 2 0 0 2 2 2 0 Caspase activity and apoptosis inhibitor 1 RCC1_2 PF13540.1 EDK36902.2 - 8e-29 98.5 18.2 1.4e-09 37.3 0.3 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 EDK36902.2 - 4.8e-20 71.5 22.3 0.00011 22.3 0.6 7.4 6 3 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DUF775 PF05603.7 EDK36903.2 - 1.2e-61 207.7 0.1 1.4e-61 207.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Cys_Met_Meta_PP PF01053.15 EDK36904.2 - 1.4e-70 237.5 0.7 1.7e-70 237.3 0.5 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EDK36904.2 - 0.00037 19.5 0.0 0.00053 19.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EDK36904.2 - 0.00042 19.4 0.2 0.0009 18.3 0.1 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Rad51 PF08423.6 EDK36904.2 - 0.057 12.3 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Rad51 OmpA PF00691.15 EDK36906.2 - 0.066 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 OmpA family GSH_synth_ATP PF03917.12 EDK36907.2 - 1.7e-117 392.1 0.0 2e-117 391.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 EDK36907.2 - 3.1e-39 133.2 0.5 9.2e-39 131.7 0.2 1.8 2 0 0 2 2 2 1 Eukaryotic glutathione synthase Peptidase_C1_2 PF03051.10 EDK36908.2 - 1.8e-160 534.3 4.4 2e-160 534.1 3.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 EDK36908.2 - 9.4e-09 35.4 0.9 0.0022 17.8 0.0 2.5 2 1 0 2 2 2 2 Papain family cysteine protease Ribosomal_S8e PF01201.17 EDK36909.1 - 4.1e-51 172.5 1.7 4.8e-51 172.3 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.8 EDK36910.2 - 1.9e-23 81.7 0.6 2.3e-23 81.4 0.4 1.1 1 0 0 1 1 1 1 CSL zinc finger Prok-RING_1 PF14446.1 EDK36910.2 - 0.22 11.2 1.2 0.46 10.2 0.8 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Myb_DNA-binding PF00249.26 EDK36911.2 - 2.1e-26 91.7 0.5 8.8e-13 48.0 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK36911.2 - 8e-22 77.1 0.8 5.2e-14 52.0 0.0 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.7 EDK36911.2 - 0.061 12.7 0.0 0.43 10.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.1 EDK36911.2 - 0.074 12.7 0.2 0.15 11.7 0.2 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Rap1_C PF11626.3 EDK36911.2 - 0.084 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain tRNA_int_endo PF01974.12 EDK36912.2 - 9.9e-16 57.3 0.0 1.6e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PNGaseA PF12222.3 EDK36913.2 - 3e-62 210.8 2.0 1.2e-61 208.9 1.4 1.8 1 1 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Vps35 PF03635.12 EDK36914.2 - 1e-227 758.0 16.4 1.4e-227 757.5 11.3 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Nucleos_tra2_C PF07662.8 EDK36915.2 - 2.2e-66 223.3 3.5 4.9e-66 222.2 2.4 1.6 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.15 EDK36915.2 - 2.4e-10 40.5 1.1 2.4e-10 40.5 0.7 3.4 5 0 0 5 5 5 1 Na+ dependent nucleoside transporter N-terminus ATG2_CAD PF13329.1 EDK36916.2 - 9.2e-41 139.0 0.1 9.2e-41 139.0 0.1 3.2 4 0 0 4 4 4 1 Autophagy-related protein 2 CAD motif Las1 PF04031.8 EDK36917.2 - 2.3e-48 163.7 0.0 8.9e-48 161.8 0.0 2.0 2 0 0 2 2 2 1 Las1-like Grp1_Fun34_YaaH PF01184.14 EDK36918.2 - 1.1e-84 283.0 21.2 1.2e-84 282.8 14.7 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF989 PF06181.6 EDK36918.2 - 0.032 13.3 1.8 0.046 12.7 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF989) CobD_Cbib PF03186.8 EDK36918.2 - 0.079 12.0 2.2 0.36 9.8 0.0 2.4 2 1 0 2 2 2 0 CobD/Cbib protein DUF4395 PF14340.1 EDK36918.2 - 1.5 8.8 20.3 2.3 8.2 0.9 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4395) Mg_trans_NIPA PF05653.9 EDK36919.2 - 7.8e-12 44.7 7.5 1.4e-06 27.4 1.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.15 EDK36919.2 - 6.7e-06 26.1 6.0 6.7e-06 26.1 4.2 3.6 2 1 1 3 3 3 1 EamA-like transporter family EmrE PF13536.1 EDK36919.2 - 1.5e-05 25.1 24.8 0.00097 19.3 2.8 3.4 2 1 0 3 3 3 3 Multidrug resistance efflux transporter NADH-u_ox-rdase PF10785.4 EDK36919.2 - 0.081 13.1 0.0 0.89 9.8 0.0 2.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Bap31 PF05529.7 EDK36919.2 - 0.35 10.2 5.1 0.38 10.1 0.1 2.6 3 0 0 3 3 3 0 B-cell receptor-associated protein 31-like RAMP4 PF06624.7 EDK36919.2 - 1.1 8.8 0.0 1.1 8.8 0.0 2.7 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 CDC14 PF08045.6 EDK36920.2 - 7.8e-74 248.0 0.6 9.1e-74 247.8 0.5 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component PHTB1_C PF14728.1 EDK36920.2 - 0.018 13.8 0.1 0.037 12.8 0.0 1.5 2 0 0 2 2 2 0 PTHB1 C-terminus DUF3722 PF12519.3 EDK36921.2 - 7.9e-83 277.6 4.8 1.3e-82 276.9 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) Mit_ribos_Mrp51 PF11709.3 EDK36922.2 - 1.1e-102 343.4 1.7 1.4e-102 343.1 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Integrin_b_cyt PF08725.6 EDK36922.2 - 1.3 8.4 4.6 0.42 10.0 0.2 2.1 2 0 0 2 2 2 0 Integrin beta cytoplasmic domain Pkinase PF00069.20 EDK36924.2 - 7.4e-65 218.6 0.0 1.1e-64 218.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK36924.2 - 4e-47 160.4 0.0 6.3e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK36924.2 - 8.7e-07 28.1 0.1 5.3e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK36924.2 - 0.00084 19.1 0.0 0.011 15.4 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 EDK36924.2 - 0.049 12.9 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.9 EDK36924.2 - 0.17 10.8 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glutaredoxin PF00462.19 EDK36924.2 - 0.56 10.2 1.7 2.1 8.4 0.2 2.4 2 0 0 2 2 2 0 Glutaredoxin IGPD PF00475.13 EDK36925.1 - 7.4e-59 197.7 2.0 1.1e-58 197.2 1.4 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase SpoU_methylase PF00588.14 EDK36926.2 - 6.8e-24 84.3 0.0 1.7e-23 83.1 0.0 1.7 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 EDK36926.2 - 9.6e-14 51.3 0.0 4.2e-13 49.2 0.0 2.1 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding DUF676 PF05057.9 EDK36927.2 - 1.5e-39 135.5 0.0 3.2e-39 134.4 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EDK36927.2 - 4e-05 23.3 0.2 0.00014 21.5 0.0 1.9 2 0 0 2 2 2 1 PGAP1-like protein Lipase_3 PF01764.20 EDK36927.2 - 0.0006 19.4 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EDK36927.2 - 0.0009 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2150 PF09920.4 EDK36927.2 - 0.028 14.0 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2150) Cutinase PF01083.17 EDK36927.2 - 0.041 13.6 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Cutinase Abhydrolase_6 PF12697.2 EDK36927.2 - 0.097 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_2 PF01674.13 EDK36927.2 - 0.11 11.7 0.6 0.28 10.4 0.4 1.6 1 1 0 1 1 1 0 Lipase (class 2) LIP PF03583.9 EDK36927.2 - 0.12 11.5 0.0 0.37 9.9 0.0 1.9 2 0 0 2 2 2 0 Secretory lipase DUF500 PF04366.7 EDK36928.1 - 3.7e-31 107.1 0.1 5.7e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) SH3_1 PF00018.23 EDK36928.1 - 9.7e-16 56.9 0.1 1.6e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EDK36928.1 - 1.7e-13 49.8 0.0 3.3e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EDK36928.1 - 1.6e-12 46.7 0.0 3e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Arm PF00514.18 EDK36929.2 - 6.7e-74 241.4 29.5 1.2e-11 44.0 0.1 11.1 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EDK36929.2 - 8.3e-24 83.6 9.0 1.3e-06 28.5 0.0 7.0 2 2 4 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 EDK36929.2 - 6.3e-17 61.5 20.5 2.4e-06 27.8 0.7 7.9 6 1 3 9 9 9 5 HEAT-like repeat HEAT PF02985.17 EDK36929.2 - 2.4e-14 52.0 25.8 0.017 15.1 0.1 9.8 11 1 0 11 11 11 4 HEAT repeat Adaptin_N PF01602.15 EDK36929.2 - 6.3e-14 51.1 4.7 5.3e-08 31.6 0.9 2.1 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.8 EDK36929.2 - 1.4e-10 40.7 6.0 0.0011 18.1 0.2 3.6 2 1 1 3 3 3 3 Armadillo-like KAP PF05804.7 EDK36929.2 - 6.7e-10 37.5 0.5 5.1e-09 34.6 0.2 2.7 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) Vac14_Fab1_bd PF12755.2 EDK36929.2 - 4.2e-05 23.8 0.1 0.57 10.6 0.0 3.2 1 1 0 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 EDK36929.2 - 0.00026 20.9 3.7 0.8 9.5 0.0 3.9 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DUF2454 PF10521.4 EDK36929.2 - 0.0016 17.5 0.1 0.22 10.4 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF2454) V-ATPase_H_C PF11698.3 EDK36929.2 - 0.0018 18.1 2.1 1.3 8.9 0.1 4.2 1 1 5 6 6 6 2 V-ATPase subunit H Snf7 PF03357.16 EDK36930.2 - 8.3e-19 67.6 20.7 1.4e-18 66.8 14.3 1.3 1 0 0 1 1 1 1 Snf7 Allexi_40kDa PF05549.6 EDK36930.2 - 4 6.6 20.9 1.1 8.5 2.7 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein ParA PF10609.4 EDK36931.2 - 5.4e-36 122.3 0.0 1.3e-35 121.1 0.0 1.6 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 EDK36931.2 - 2.8e-15 56.2 0.0 4.3e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EDK36931.2 - 2.5e-06 27.5 0.0 9.8e-06 25.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain MipZ PF09140.6 EDK36931.2 - 1.3e-05 24.4 0.0 2.3e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 EDK36931.2 - 0.00069 18.7 0.1 0.0039 16.2 0.0 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase DUF258 PF03193.11 EDK36931.2 - 0.0048 16.1 0.0 0.009 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 EDK36931.2 - 0.0069 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.1 EDK36931.2 - 0.014 14.9 0.0 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.13 EDK36931.2 - 0.1 11.7 0.0 0.52 9.4 0.0 2.0 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_29 PF13555.1 EDK36931.2 - 0.15 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zn_Tnp_IS1595 PF12760.2 EDK36931.2 - 4.6 7.1 5.4 0.86 9.4 0.2 2.3 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Nup96 PF12110.3 EDK36932.2 - 1e-52 179.1 1.0 1.9e-52 178.1 0.7 1.5 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 EDK36932.2 - 3.2e-47 159.8 0.0 7.3e-47 158.7 0.0 1.7 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 EDK36932.2 - 0.79 9.9 60.8 0.31 11.2 36.2 3.3 2 1 0 2 2 2 0 Nucleoporin FG repeat region YjeF_N PF03853.10 EDK36933.2 - 5.9e-35 120.3 0.0 8.5e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 EDK36933.2 - 1.5e-07 31.8 2.6 5.5e-07 30.0 1.8 2.0 1 1 0 1 1 1 1 FDF domain ROF PF07073.7 EDK36933.2 - 0.13 12.3 0.1 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) MFS_1 PF07690.11 EDK36934.2 - 3.7e-28 98.2 55.9 1.5e-23 83.1 28.7 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily UBX PF00789.15 EDK36935.2 - 5.8e-09 35.8 0.0 1.9e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 UBX domain WD40 PF00400.27 EDK36936.2 - 0.0028 17.4 1.6 0.43 10.5 0.0 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PALP PF00291.20 EDK36937.2 - 5.1e-59 200.0 0.0 6.7e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 EDK36937.2 - 5.5e-14 51.6 0.0 6e-11 41.9 0.0 2.5 2 0 0 2 2 2 2 CBS domain TFIIS_M PF07500.9 EDK36938.2 - 1.3e-31 109.0 0.9 1.7e-31 108.6 0.6 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 EDK36938.2 - 1.2e-18 66.4 7.6 2.3e-18 65.5 5.3 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.3 EDK36938.2 - 0.0027 17.0 2.2 0.0044 16.3 1.5 1.3 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain Elf1 PF05129.8 EDK36938.2 - 0.0084 15.7 2.8 0.015 14.9 1.9 1.4 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.2 EDK36938.2 - 0.52 10.1 6.5 3.4 7.5 4.6 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_S27 PF01599.14 EDK36938.2 - 1.1 9.1 6.5 2.1 8.2 0.6 2.3 1 1 1 2 2 2 0 Ribosomal protein S27a RRM_1 PF00076.17 EDK36939.1 - 9.1e-16 57.2 0.0 1.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 EDK36939.1 - 3.6e-14 52.6 2.5 5.9e-14 51.9 1.7 1.4 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_6 PF14259.1 EDK36939.1 - 3.6e-14 52.4 0.0 6.1e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36939.1 - 3e-06 27.0 0.0 5.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec63 PF02889.11 EDK36939.1 - 0.027 13.7 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Sec63 Brl domain CSTF_C PF14304.1 EDK36939.1 - 0.033 13.4 0.0 0.099 11.9 0.0 1.8 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.1 EDK36940.2 - 7.9e-25 86.7 2.2 9.1e-25 86.5 0.1 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.1 EDK36940.2 - 8.2e-11 41.0 1.1 3.3e-10 39.0 0.7 2.1 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.17 EDK36940.2 - 1.8e-10 40.2 0.0 4.1e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK36940.2 - 8.1e-07 28.9 0.0 1.7e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK36940.2 - 0.0086 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.1 EDK36941.2 - 5.8e-12 45.2 8.7 3.3e-10 39.6 0.6 3.1 3 0 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.2 EDK36941.2 - 4.3e-10 39.5 1.9 1.9e-07 31.0 0.2 2.4 2 0 0 2 2 2 2 RING-H2 zinc finger zf-C3HC4 PF00097.20 EDK36941.2 - 3.3e-05 23.4 0.9 3.3e-05 23.4 0.6 3.1 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK36941.2 - 8.3e-05 22.3 1.1 0.00038 20.2 0.2 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 EDK36941.2 - 0.00018 21.4 10.1 0.00021 21.2 1.1 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 EDK36941.2 - 0.00025 20.7 0.5 0.0096 15.6 0.1 2.4 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 EDK36941.2 - 0.0003 20.4 0.7 0.0003 20.4 0.5 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK36941.2 - 0.00053 19.6 6.8 0.0033 17.0 0.5 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 EDK36941.2 - 0.00075 18.9 0.7 0.00075 18.9 0.5 2.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EDK36941.2 - 0.0023 17.6 0.3 0.0023 17.6 0.2 3.0 3 0 0 3 3 3 1 RING-type zinc-finger FANCL_C PF11793.3 EDK36941.2 - 0.034 14.1 4.2 2.6 8.0 0.7 3.2 2 1 0 2 2 2 0 FANCL C-terminal domain zf-piccolo PF05715.8 EDK36941.2 - 0.094 12.7 1.5 6.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Piccolo Zn-finger zf-RING_4 PF14570.1 EDK36941.2 - 0.57 9.8 3.4 1.7 8.3 0.2 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 EDK36941.2 - 0.58 10.0 12.3 0.06 13.2 1.4 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING DUF329 PF03884.9 EDK36941.2 - 1.3 8.6 6.3 3 7.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF329) DUF2225 PF09986.4 EDK36941.2 - 1.5 8.2 5.8 6.5 6.1 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Fungal_trans PF04082.13 EDK36943.2 - 8.7e-67 224.7 7.7 8.7e-67 224.7 5.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EDK36943.2 - 1.4e-05 25.1 2.3 1.4e-05 25.1 1.6 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK36943.2 - 4.9e-05 23.3 15.2 0.00036 20.6 0.9 3.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK36943.2 - 3.8 7.9 13.4 1.1 9.7 0.2 4.1 3 1 0 3 3 3 0 Zinc-finger double domain Ribosomal_S8e PF01201.17 EDK36944.2 - 2e-40 137.9 3.6 3.3e-40 137.2 2.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e HPD PF05044.7 EDK36944.2 - 0.019 14.6 0.8 0.058 13.0 0.2 1.9 2 0 0 2 2 2 0 Homeo-prospero domain DUF3959 PF13105.1 EDK36944.2 - 3.3 6.9 8.3 1 8.6 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) Sas10_Utp3 PF04000.10 EDK36945.2 - 5.8e-10 39.2 0.5 5.8e-10 39.2 0.4 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family NHR2 PF08788.6 EDK36945.2 - 0.02 14.3 0.0 0.049 13.1 0.0 1.6 1 0 0 1 1 1 0 NHR2 domain like NTS_2 PF15448.1 EDK36945.2 - 0.071 13.4 3.2 10 6.5 0.2 3.1 3 0 0 3 3 3 0 N-terminal segments of P. falciparum erythrocyte membrane protein FliP PF00813.15 EDK36945.2 - 0.11 12.1 2.3 0.53 9.9 0.0 2.3 2 0 0 2 2 2 0 FliP family XPC-binding PF09280.6 EDK36945.2 - 0.12 11.8 0.1 0.29 10.6 0.1 1.6 1 0 0 1 1 1 0 XPC-binding domain PUF PF00806.14 EDK36946.2 - 1.2e-57 188.2 24.4 1.1e-07 30.9 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Erf4 PF10256.4 EDK36946.2 - 1.6 8.6 6.8 2.3 8.1 0.2 3.2 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family bZIP_1 PF00170.16 EDK36947.2 - 0.0018 18.1 5.4 0.0018 18.1 3.7 3.2 3 1 1 4 4 4 2 bZIP transcription factor Kinetocho_Slk19 PF12709.2 EDK36947.2 - 0.004 17.1 16.5 0.0042 17.1 9.0 2.8 1 1 2 3 3 3 1 Central kinetochore-associated Shugoshin_N PF07558.6 EDK36947.2 - 0.018 14.7 3.5 0.018 14.7 2.4 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TSC22 PF01166.13 EDK36947.2 - 0.089 12.7 6.1 0.18 11.8 1.0 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family NYD-SP28_assoc PF14775.1 EDK36947.2 - 0.1 12.3 11.2 1.7 8.3 1.7 3.5 3 0 0 3 3 3 0 Sperm tail C-terminal domain bZIP_2 PF07716.10 EDK36947.2 - 0.26 11.1 17.5 0.12 12.1 4.1 3.3 3 0 0 3 3 3 0 Basic region leucine zipper OmpH PF03938.9 EDK36947.2 - 1.1 9.1 14.5 3.9 7.3 8.9 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Nucleoporin_FG PF13634.1 EDK36948.2 - 9.6e-33 112.8 165.9 2.2e-12 47.2 31.6 4.4 1 1 3 4 4 4 4 Nucleoporin FG repeat region LOH1CR12 PF10158.4 EDK36948.2 - 0.32 10.7 4.4 1.5 8.6 0.7 2.6 1 1 0 2 2 2 0 Tumour suppressor protein Occludin_ELL PF07303.8 EDK36948.2 - 0.38 11.5 3.8 6.4 7.5 0.2 3.1 2 1 1 3 3 3 0 Occludin homology domain Fib_alpha PF08702.5 EDK36948.2 - 0.68 10.0 7.7 0.52 10.4 1.1 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Dad2 PF08654.5 EDK36948.2 - 0.79 9.7 2.9 9 6.3 0.1 2.4 1 1 1 2 2 2 0 DASH complex subunit Dad2 IncA PF04156.9 EDK36948.2 - 1.6 8.2 6.3 11 5.5 0.6 2.1 1 1 1 2 2 2 0 IncA protein BLOC1_2 PF10046.4 EDK36948.2 - 3.6 7.7 8.3 20 5.4 1.3 3.4 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Bud13 PF09736.4 EDK36949.2 - 6.1e-41 140.0 5.2 6.1e-41 140.0 3.6 1.7 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex MUG2_C PF08593.5 EDK36949.2 - 0.1 12.8 0.2 0.37 11.0 0.0 2.1 2 0 0 2 2 2 0 Meiotically up-regulated glycoproteins C-terminal CENP-H PF05837.7 EDK36949.2 - 0.37 10.9 6.8 0.97 9.6 4.7 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) V_ATPase_I PF01496.14 EDK36949.2 - 0.6 7.8 2.9 0.77 7.5 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1170 PF06663.8 EDK36950.2 - 0.12 12.3 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) Mito_carr PF00153.22 EDK36951.1 - 6.8e-74 243.6 1.3 1.5e-26 91.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 EDK36951.1 - 0.028 14.5 3.7 0.31 11.2 0.0 3.7 4 0 0 4 4 4 0 EF-hand domain pair YtxH PF12732.2 EDK36951.1 - 0.12 12.8 0.0 0.42 11.0 0.0 2.0 1 0 0 1 1 1 0 YtxH-like protein EF-hand_1 PF00036.27 EDK36951.1 - 0.24 10.7 1.4 42 3.7 0.0 3.9 4 0 0 4 4 4 0 EF hand XRN_N PF03159.13 EDK36952.2 - 3.7e-82 275.2 0.1 6.2e-82 274.5 0.1 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus DUF3047 PF11249.3 EDK36952.2 - 0.013 14.8 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3047) zf-C2H2 PF00096.21 EDK36954.2 - 1.2e-09 37.9 20.0 0.0012 19.1 0.3 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK36954.2 - 1.2e-07 31.6 5.7 1.1e-06 28.5 0.4 4.5 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK36954.2 - 2.9e-05 24.0 25.9 0.012 15.9 1.9 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EDK36954.2 - 3.2e-05 23.6 12.1 0.0048 16.7 0.1 4.2 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK36954.2 - 0.00054 20.0 6.7 1 9.6 0.3 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.1 EDK36954.2 - 0.0062 16.1 0.5 0.0062 16.1 0.4 2.4 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-met PF12874.2 EDK36954.2 - 0.17 12.1 15.6 3.2 8.1 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type C1_4 PF07975.7 EDK36954.2 - 0.51 10.3 6.7 6 6.9 0.7 2.7 1 1 0 2 2 2 0 TFIIH C1-like domain zf-CHY PF05495.7 EDK36954.2 - 0.65 10.1 10.5 1.7 8.8 5.9 2.5 1 1 1 2 2 2 0 CHY zinc finger zf-FCS PF06467.9 EDK36954.2 - 0.71 9.5 5.6 0.9 9.2 0.5 2.8 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_ribbon_recom PF13408.1 EDK36954.2 - 0.89 9.8 6.9 12 6.1 0.2 2.8 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DZR PF12773.2 EDK36954.2 - 1.6 8.6 5.8 20 5.0 0.2 2.5 1 1 1 2 2 2 0 Double zinc ribbon zf-HIT PF04438.11 EDK36954.2 - 7.4 6.3 9.1 35 4.1 0.3 3.3 3 0 0 3 3 3 0 HIT zinc finger Pkinase PF00069.20 EDK36955.2 - 3.6e-05 23.0 0.0 7.5e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Response_reg PF00072.19 EDK36956.2 - 5.6e-21 74.6 0.0 1.2e-14 54.2 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Asp_protease PF09668.5 EDK36957.2 - 2.1e-47 159.7 0.1 3.1e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 EDK36957.2 - 2.2e-12 47.2 0.1 6.6e-12 45.7 0.1 1.9 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.26 EDK36957.2 - 9.6e-10 38.0 0.0 2.4e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.15 EDK36957.2 - 1e-09 38.2 0.1 6.4e-09 35.6 0.0 2.3 2 1 0 2 2 2 1 Retroviral aspartyl protease ubiquitin PF00240.18 EDK36957.2 - 2e-09 36.7 0.3 4.3e-09 35.6 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin family gag-asp_proteas PF13975.1 EDK36957.2 - 2.9e-07 30.2 0.0 8.7e-07 28.6 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Rad60-SLD PF11976.3 EDK36957.2 - 1.8e-05 24.3 0.2 4.7e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP_2 PF08284.6 EDK36957.2 - 0.0003 20.7 0.1 0.00063 19.6 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.1 EDK36957.2 - 0.0048 16.4 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain ThiS-like PF14453.1 EDK36957.2 - 0.68 9.8 4.2 0.39 10.6 0.8 2.3 2 1 0 2 2 2 0 ThiS-like ubiquitin Aldo_ket_red PF00248.16 EDK36958.1 - 3.3e-47 160.6 0.0 4.1e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GDI PF00996.13 EDK36959.2 - 2.2e-135 451.3 0.1 2.4e-135 451.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Peptidase_M24 PF00557.19 EDK36960.2 - 2.4e-55 187.3 0.0 3.8e-55 186.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EDK36960.2 - 2.2e-21 75.6 0.1 4.8e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain PBS_linker_poly PF00427.16 EDK36960.2 - 0.052 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide JAB PF01398.16 EDK36961.2 - 7.2e-36 122.3 0.2 1.8e-35 121.1 0.2 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 EDK36961.2 - 3.2e-27 94.8 4.6 8.4e-27 93.5 3.0 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 EDK36961.2 - 6.5e-09 35.3 0.0 1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UCH PF00443.24 EDK36962.2 - 4.8e-17 61.9 0.2 8.4e-17 61.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EDK36962.2 - 8.2e-11 41.8 2.3 8.2e-11 41.8 1.6 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein DUF2731 PF10806.3 EDK36963.2 - 2.6e-37 127.8 0.1 1.2e-36 125.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2731) Acetyltransf_7 PF13508.1 EDK36964.1 - 4.1e-08 33.2 0.0 5.7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EDK36964.1 - 2.8e-07 30.4 0.0 4.6e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 EDK36964.1 - 0.0016 18.3 0.0 0.0024 17.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EDK36964.1 - 0.016 15.0 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 EDK36964.1 - 0.018 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.1 EDK36964.1 - 0.051 13.6 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CAF1C_H4-bd PF12265.3 EDK36965.2 - 2.9e-23 81.5 0.6 5.2e-23 80.7 0.4 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 EDK36965.2 - 1.5e-21 75.3 7.3 3.2e-06 26.8 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Sulfate_transp PF00916.15 EDK36966.2 - 4e-51 173.6 7.2 5.5e-51 173.2 2.5 2.4 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EDK36966.2 - 1.1e-22 79.4 6.0 1.1e-22 79.4 4.2 2.2 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EDK36966.2 - 4.4e-16 58.3 0.0 2.8e-15 55.7 0.0 2.2 2 0 0 2 2 2 1 STAS domain DUF1427 PF07235.6 EDK36966.2 - 0.019 15.0 0.5 0.078 13.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1427) ETF_alpha PF00766.14 EDK36967.1 - 6.9e-37 124.9 0.1 1.5e-36 123.8 0.1 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.16 EDK36967.1 - 9.4e-35 119.7 0.6 1.4e-34 119.1 0.1 1.5 2 0 0 2 2 2 1 Electron transfer flavoprotein domain DUF4553 PF15090.1 EDK36968.2 - 0.047 12.6 3.7 0.064 12.2 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) DUF4175 PF13779.1 EDK36968.2 - 3.3 5.2 18.1 4.7 4.7 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Fungal_trans PF04082.13 EDK36969.2 - 4.7e-18 64.9 0.3 8.7e-18 64.1 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK36969.2 - 1e-05 25.3 8.4 1.7e-05 24.6 5.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC92 PF14916.1 EDK36969.2 - 0.02 14.4 0.1 0.044 13.3 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil domain of unknown function LRR_4 PF12799.2 EDK36970.2 - 1.2e-30 104.6 30.5 2.1e-08 33.5 2.7 7.8 5 2 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK36970.2 - 9.8e-27 92.4 24.2 2.4e-11 43.2 1.8 6.8 5 1 1 6 6 6 6 Leucine rich repeat LRR_7 PF13504.1 EDK36970.2 - 6.4e-16 55.6 21.1 0.26 11.6 0.0 11.1 10 0 0 10 10 10 4 Leucine rich repeat LRR_1 PF00560.28 EDK36970.2 - 1.6e-15 54.7 25.4 0.066 13.2 0.1 10.7 7 3 2 9 9 9 5 Leucine Rich Repeat LRR_6 PF13516.1 EDK36970.2 - 2.7e-14 51.5 31.9 0.081 13.0 0.1 11.4 9 2 2 11 11 11 5 Leucine Rich repeat LRR_9 PF14580.1 EDK36970.2 - 0.004 16.7 5.4 0.63 9.5 0.1 3.7 1 1 3 4 4 4 2 Leucine-rich repeat FNIP PF05725.7 EDK36970.2 - 0.0071 16.2 14.8 0.059 13.3 0.9 4.8 4 1 2 6 6 6 4 FNIP Repeat F-box-like PF12937.2 EDK36970.2 - 0.11 12.2 0.0 0.29 10.8 0.0 1.8 1 0 0 1 1 1 0 F-box-like CAP PF00188.21 EDK36971.2 - 1.2e-18 67.7 5.1 2e-18 67.0 3.6 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CPSF100_C PF13299.1 EDK36971.2 - 0.13 12.4 0.3 0.19 11.9 0.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal AAA_12 PF13087.1 EDK36972.2 - 1.6e-58 197.3 0.0 4.4e-58 195.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EDK36972.2 - 1.1e-55 188.8 0.1 2.1e-55 187.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK36972.2 - 6.6e-12 45.0 0.0 1.8e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EDK36972.2 - 6.6e-08 32.3 0.0 9.6e-07 28.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EDK36972.2 - 1e-06 28.5 0.0 1.1 8.7 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 EDK36972.2 - 4e-06 26.7 0.1 0.00019 21.3 0.1 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 EDK36972.2 - 1.7e-05 24.1 0.0 0.0033 16.6 0.0 3.1 3 0 0 3 3 3 1 PhoH-like protein AAA_22 PF13401.1 EDK36972.2 - 8.8e-05 22.6 0.1 0.00043 20.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.1 EDK36972.2 - 0.00012 22.5 8.2 0.00016 22.0 4.0 2.4 2 1 0 2 2 1 1 AAA domain Helicase_RecD PF05127.9 EDK36972.2 - 0.0002 21.0 0.0 0.00054 19.6 0.0 1.8 1 0 0 1 1 1 1 Helicase DUF2075 PF09848.4 EDK36972.2 - 0.00088 18.3 0.0 0.0038 16.2 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.9 EDK36972.2 - 0.0011 17.9 0.0 0.46 9.3 0.0 2.4 2 0 0 2 2 2 2 PIF1-like helicase AAA_16 PF13191.1 EDK36972.2 - 0.0041 17.1 0.0 0.0084 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK36972.2 - 0.0044 17.8 0.0 0.018 15.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EDK36972.2 - 0.0062 16.8 0.2 0.037 14.3 0.1 2.4 1 1 0 1 1 1 1 ABC transporter UvrD-helicase PF00580.16 EDK36972.2 - 0.0062 15.8 0.7 0.015 14.6 0.5 1.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_14 PF13173.1 EDK36972.2 - 0.0062 16.4 0.0 0.051 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EDK36972.2 - 0.0079 16.3 0.0 0.026 14.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 EDK36972.2 - 0.012 15.1 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_5 PF07728.9 EDK36972.2 - 0.014 15.1 0.0 0.04 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 EDK36972.2 - 0.015 15.0 0.4 0.037 13.7 0.3 1.7 1 0 0 1 1 1 0 Archaeal ATPase AAA_33 PF13671.1 EDK36972.2 - 0.025 14.4 0.0 0.051 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Zot PF05707.7 EDK36972.2 - 0.025 14.0 0.0 0.052 13.0 0.0 1.5 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) DUF4391 PF14335.1 EDK36972.2 - 0.026 13.9 0.6 0.026 13.9 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4391) AAA_18 PF13238.1 EDK36972.2 - 0.028 14.7 2.0 0.1 12.9 0.2 2.7 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 EDK36972.2 - 0.061 12.7 0.1 0.36 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Herpes_ori_bp PF02399.10 EDK36972.2 - 0.078 10.9 0.0 0.12 10.2 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein P63C PF10546.4 EDK36972.2 - 0.087 12.7 0.0 10 6.1 0.0 2.8 2 0 0 2 2 2 0 P63C domain 4HB_MCP_1 PF12729.2 EDK36972.2 - 0.11 11.8 4.8 0.038 13.3 1.2 1.8 2 0 0 2 2 1 0 Four helix bundle sensory module for signal transduction Fip1 PF05182.8 EDK36973.1 - 8.4e-24 82.5 0.7 1.9e-23 81.4 0.5 1.6 1 0 0 1 1 1 1 Fip1 motif Anillin PF08174.6 EDK36974.2 - 7.8e-19 68.1 0.2 3.7e-18 65.9 0.2 2.2 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.24 EDK36974.2 - 2e-11 44.0 0.1 8.6e-11 41.9 0.0 2.2 1 0 0 1 1 1 1 PH domain Recep_L_domain PF01030.19 EDK36975.1 - 2.8e-08 33.7 11.1 0.0053 16.7 0.3 4.6 1 1 1 3 3 3 2 Receptor L domain DUF3316 PF11777.3 EDK36975.1 - 0.001 18.8 3.2 1.9 8.2 0.0 3.6 3 1 0 3 3 3 2 Protein of unknown function (DUF3316) LRR_9 PF14580.1 EDK36975.1 - 0.053 13.0 0.5 0.15 11.6 0.4 1.8 1 1 0 1 1 1 0 Leucine-rich repeat Dockerin_1 PF00404.13 EDK36975.1 - 0.084 12.6 2.3 0.29 10.8 0.5 2.8 2 0 0 2 2 2 0 Dockerin type I repeat Macoilin PF09726.4 EDK36975.1 - 0.34 9.1 9.6 0.5 8.5 6.6 1.2 1 0 0 1 1 1 0 Transmembrane protein SR-25 PF10500.4 EDK36975.1 - 4.9 6.5 23.9 7.6 5.9 16.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UDPGP PF01704.13 EDK36976.2 - 6.4e-47 159.9 0.0 8.7e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 EDK36976.2 - 0.077 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain FGGY_C PF02782.11 EDK36977.2 - 3e-69 232.6 0.3 7.4e-69 231.3 0.2 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EDK36977.2 - 6.2e-52 176.3 0.4 2.8e-44 151.2 0.1 3.1 1 1 1 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain adh_short PF00106.20 EDK36978.1 - 2e-14 53.8 0.0 2.6e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK36978.1 - 7.2e-09 35.7 0.0 9.2e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK36978.1 - 2e-06 27.6 0.0 2.7e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK36978.1 - 0.017 15.1 0.1 0.023 14.6 0.1 1.2 1 0 0 1 1 1 0 NADH(P)-binding TrkA_N PF02254.13 EDK36978.1 - 0.023 14.7 0.2 0.1 12.5 0.0 1.9 1 1 1 2 2 2 0 TrkA-N domain F420_oxidored PF03807.12 EDK36978.1 - 0.12 12.7 0.1 0.19 12.1 0.1 1.5 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.20 EDK36979.2 - 0.15 11.9 0.2 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Herpes_UL25 PF01499.11 EDK36983.2 - 0.012 13.9 4.3 0.022 13.1 0.4 2.3 2 0 0 2 2 2 0 Herpesvirus UL25 family CHASE3 PF05227.8 EDK36983.2 - 0.015 15.0 1.0 0.015 15.0 0.7 2.6 2 1 0 2 2 2 0 CHASE3 domain Prominin PF05478.6 EDK36983.2 - 0.017 12.6 8.7 0.0033 15.0 3.1 1.7 2 0 0 2 2 2 0 Prominin MtrB PF05440.7 EDK36983.2 - 0.068 13.2 0.1 0.84 9.7 0.1 2.7 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B Baculo_PEP_C PF04513.7 EDK36983.2 - 0.24 11.1 2.4 9.2 6.0 0.1 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus AA_permease PF00324.16 EDK36984.2 - 1.2e-70 238.2 48.7 1.4e-70 237.9 33.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK36984.2 - 1.4e-21 76.5 53.6 6.1e-21 74.4 37.1 1.7 1 1 0 1 1 1 1 Amino acid permease Halogen_Hydrol PF10112.4 EDK36984.2 - 2.4 7.5 4.5 4.3 6.7 1.7 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Gln-synt_C PF00120.19 EDK36985.1 - 9.2e-63 211.7 0.0 1.1e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 EDK36985.1 - 6.3e-20 70.5 0.0 1e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.9 EDK36986.2 - 9.1e-44 149.8 4.2 9.1e-44 149.8 2.9 1.7 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 EDK36986.2 - 7.2e-19 67.8 0.5 3.2e-18 65.7 0.1 2.2 2 0 0 2 2 2 1 V-ATPase subunit H BIR PF00653.16 EDK36987.2 - 3.9e-35 120.1 10.7 5.3e-19 68.4 1.1 3.1 2 1 0 2 2 2 2 Inhibitor of Apoptosis domain SAPS PF04499.10 EDK36988.2 - 1.7e-146 488.6 0.1 1.7e-146 488.6 0.0 2.3 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein DnaJ PF00226.26 EDK36989.2 - 3.6e-16 58.6 0.1 1.2e-15 56.9 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain PTPLA PF04387.9 EDK36990.2 - 2.3e-14 53.1 7.4 2.3e-14 53.1 5.1 1.9 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA MFS_1 PF07690.11 EDK36991.2 - 3.6e-29 101.5 50.3 3.4e-23 81.9 23.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK36991.2 - 0.14 10.6 39.2 0.15 10.6 10.0 2.6 2 1 1 3 3 3 0 Sugar (and other) transporter bZIP_1 PF00170.16 EDK36992.1 - 2.2e-10 40.3 8.7 3.4e-10 39.7 6.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EDK36992.1 - 7.5e-05 22.4 6.6 0.00013 21.6 4.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EDK36992.1 - 0.0065 16.7 7.5 0.013 15.7 5.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Pex24p PF06398.6 EDK36993.1 - 0.11 11.2 8.2 0.14 10.9 5.7 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin MIP-T3 PF10243.4 EDK36994.2 - 0.25 9.7 6.5 0.44 8.9 4.5 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Calc_CGRP_IAPP PF00214.14 EDK36994.2 - 3.9 7.5 10.8 0.56 10.2 4.3 1.8 2 0 0 2 2 2 0 Calcitonin / CGRP / IAPP family K_oxygenase PF13434.1 EDK36995.2 - 0.092 11.6 1.7 0.13 11.1 1.2 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) CDP-OH_P_transf PF01066.16 EDK36996.2 - 4.4e-20 71.8 3.5 4.4e-20 71.8 2.4 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TRIQK PF15168.1 EDK36996.2 - 0.53 10.2 2.4 2.2 8.2 0.0 2.8 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family GHMP_kinases_N PF00288.21 EDK36997.2 - 2e-10 40.5 0.7 4.5e-10 39.4 0.5 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain WD40 PF00400.27 EDK36998.2 - 7.9e-65 212.6 17.4 3.7e-12 45.6 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 EDK36998.2 - 5.8e-29 100.1 11.1 9.7e-29 99.3 7.7 1.4 1 0 0 1 1 1 1 Tup N-terminal Nup160 PF11715.3 EDK36998.2 - 6.1e-06 24.6 5.0 0.071 11.2 0.0 4.6 1 1 4 5 5 5 2 Nucleoporin Nup120/160 IKI3 PF04762.7 EDK36998.2 - 0.00083 17.3 0.0 0.0025 15.7 0.0 1.8 1 1 0 1 1 1 1 IKI3 family PD40 PF07676.7 EDK36998.2 - 0.0037 16.8 0.0 12 5.7 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 EDK36998.2 - 0.0043 16.1 0.2 4.9 6.1 0.0 4.0 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.6 EDK36998.2 - 0.0068 15.2 2.5 1.8 7.1 0.0 3.3 1 1 3 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.11 EDK36998.2 - 0.02 13.1 0.1 0.26 9.5 0.1 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.4 EDK36998.2 - 0.048 12.9 0.1 3.4 7.0 0.0 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature APC_CDC26 PF10471.4 EDK36998.2 - 0.3 11.8 0.1 0.3 11.8 0.1 2.9 3 1 0 3 3 1 0 Anaphase-promoting complex APC subunit 1 TEX13 PF15186.1 EDK36998.2 - 0.46 10.0 5.8 0.95 9.0 4.0 1.5 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family RseA_C PF03873.8 EDK36998.2 - 7.4 6.5 9.1 1.1 9.1 1.8 2.7 3 0 0 3 3 3 0 Anti sigma-E protein RseA, C-terminal domain COX16 PF14138.1 EDK36999.1 - 4.4e-30 103.6 1.6 6.7e-30 103.0 1.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Arc_PepC_II PF06847.6 EDK36999.1 - 0.14 12.5 0.7 0.52 10.7 0.0 2.0 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II zf-LYAR PF08790.6 EDK37000.1 - 6.7e-16 57.6 2.7 6.7e-16 57.6 1.8 2.0 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger Ndc1_Nup PF09531.5 EDK37000.1 - 0.061 11.7 3.6 0.068 11.5 2.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DM PF00751.13 EDK37000.1 - 0.07 12.6 1.7 0.14 11.6 1.2 1.5 1 0 0 1 1 1 0 DM DNA binding domain RR_TM4-6 PF06459.7 EDK37000.1 - 0.64 9.8 11.2 0.85 9.4 7.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ECSIT PF06239.6 EDK37000.1 - 2.2 7.0 6.9 2.7 6.7 3.9 1.8 2 1 1 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway TORC_M PF12885.2 EDK37000.1 - 2.8 7.7 10.2 1.7 8.4 5.5 1.8 2 1 1 3 3 3 0 Transducer of regulated CREB activity middle domain Csm1 PF12539.3 EDK37001.2 - 1.8e-27 95.6 0.1 1.8e-27 95.6 0.0 1.8 2 1 0 2 2 2 1 Chromosome segregation protein Csm1/Pcs1 DUF641 PF04859.7 EDK37001.2 - 0.011 15.4 2.2 0.02 14.6 1.5 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Cwf_Cwc_15 PF04889.7 EDK37001.2 - 0.015 15.0 4.5 0.021 14.5 3.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein p25-alpha PF05517.7 EDK37001.2 - 0.033 14.4 0.7 0.053 13.7 0.5 1.3 1 0 0 1 1 1 0 p25-alpha DUF4617 PF15395.1 EDK37001.2 - 0.052 11.6 7.8 0.067 11.2 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4617) SlyX PF04102.7 EDK37001.2 - 0.55 10.6 6.2 1.2 9.5 4.3 1.6 1 0 0 1 1 1 0 SlyX CTD_bind PF04818.8 EDK37002.2 - 2.4e-23 82.1 0.0 5.2e-23 81.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. UvrD_C PF13361.1 EDK37003.2 - 1.1e-35 123.8 0.0 3e-33 115.7 0.0 3.0 2 2 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 EDK37003.2 - 9.6e-32 110.5 0.0 1.7e-15 57.1 0.0 2.3 1 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 EDK37003.2 - 8.4e-13 47.8 0.0 3.3e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 EDK37003.2 - 6.5e-11 42.3 0.0 1.9e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 EDK37003.2 - 3.1e-07 30.1 0.0 0.027 13.9 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 EDK37003.2 - 1.2e-06 28.2 0.1 3.9e-06 26.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain DEAD PF00270.24 EDK37003.2 - 0.00013 21.5 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.1 EDK37003.2 - 0.001 18.6 0.0 0.0033 17.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 EDK37003.2 - 0.0023 17.3 0.0 0.14 11.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 EDK37003.2 - 0.0057 16.7 0.0 2.9 8.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.9 EDK37003.2 - 0.012 15.2 0.0 0.058 13.0 0.0 2.0 2 0 0 2 2 2 0 Helicase Herpes_ori_bp PF02399.10 EDK37003.2 - 0.041 11.8 0.7 0.11 10.4 0.5 1.6 1 1 0 1 1 1 0 Origin of replication binding protein Pox_VLTF3 PF04947.9 EDK37003.2 - 0.078 12.4 0.6 0.16 11.4 0.4 1.4 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like PhoH PF02562.11 EDK37003.2 - 0.18 11.0 0.1 5.7 6.1 0.0 2.4 2 1 0 2 2 2 0 PhoH-like protein Vps52 PF04129.7 EDK37004.2 - 5.2e-83 279.3 0.4 2.4e-55 188.0 0.2 2.1 1 1 1 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.4 EDK37004.2 - 1.7e-05 23.1 1.2 3.3e-05 22.2 0.8 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec3 Rep_fac_C PF08542.6 EDK37005.2 - 2e-22 78.9 0.0 9.5e-22 76.7 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.24 EDK37005.2 - 8.6e-12 45.3 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EDK37005.2 - 1.5e-11 44.2 0.1 8.6e-10 38.5 0.1 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_3 PF07726.6 EDK37005.2 - 1.7e-07 30.8 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EDK37005.2 - 7.1e-07 29.1 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EDK37005.2 - 3.7e-06 26.1 0.1 1.1e-05 24.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EDK37005.2 - 8.8e-06 25.8 0.1 0.06 13.4 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 EDK37005.2 - 2.1e-05 24.5 0.0 0.00076 19.5 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.10 EDK37005.2 - 2.3e-05 23.2 0.0 0.0022 16.7 0.0 2.4 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 EDK37005.2 - 0.00036 20.1 0.0 0.00067 19.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.13 EDK37005.2 - 0.00041 19.9 0.0 0.00078 18.9 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EDK37005.2 - 0.00065 19.2 0.0 0.12 11.7 0.0 2.4 1 1 0 2 2 2 1 AAA-like domain Mg_chelatase PF01078.16 EDK37005.2 - 0.002 17.2 0.0 0.033 13.3 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EDK37005.2 - 0.012 15.2 0.0 0.037 13.7 0.0 1.8 2 0 0 2 2 2 0 Part of AAA domain DNA_pol3_delta PF06144.8 EDK37005.2 - 0.022 14.2 0.1 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NTPase_1 PF03266.10 EDK37005.2 - 0.032 13.9 0.1 0.2 11.3 0.1 2.1 1 1 1 2 2 2 0 NTPase ArgK PF03308.11 EDK37005.2 - 0.035 12.8 0.1 0.65 8.7 0.0 2.3 1 1 1 2 2 2 0 ArgK protein DUF4397 PF14344.1 EDK37005.2 - 0.063 13.6 0.0 0.27 11.5 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4397) DEAD PF00270.24 EDK37005.2 - 0.064 12.7 0.0 2.2 7.7 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase KTI12 PF08433.5 EDK37005.2 - 0.089 11.9 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.1 EDK37005.2 - 0.13 11.6 0.0 1.5 8.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain RNase_P_pop3 PF08228.6 EDK37006.2 - 5.2e-22 78.3 0.2 1.1e-20 74.0 0.1 2.1 1 1 0 1 1 1 1 RNase P subunit Pop3 RNA_pol_Rpb1_R PF05001.8 EDK37007.2 - 6.1e-07 29.0 69.5 0.024 14.7 10.2 4.4 2 1 0 4 4 4 4 RNA polymerase Rpb1 C-terminal repeat TCL1_MTCP1 PF01840.12 EDK37007.2 - 9.8 5.6 11.0 5.1 6.6 1.2 2.7 1 1 1 2 2 2 0 TCL1/MTCP1 family RNA_pol_Rpb1_5 PF04998.12 EDK37008.1 - 3.8e-111 370.7 0.0 5e-111 370.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_6 PF04992.9 EDK37008.1 - 5.3e-65 218.6 1.7 3.8e-64 215.8 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.7 EDK37008.1 - 4.3e-48 162.4 4.9 4.5e-48 162.3 2.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 EDK37008.1 - 1.1e-27 95.9 0.1 2.9e-27 94.5 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 EDK37008.1 - 1.8e-13 49.3 169.3 0.15 12.2 10.2 10.0 3 1 1 9 9 9 8 RNA polymerase Rpb1 C-terminal repeat RNA_pol_Rpb1_2 PF00623.15 EDK37009.1 - 7.6e-72 240.6 0.0 1e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EDK37009.1 - 5.1e-16 58.7 0.0 7.6e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.7 EDK37009.1 - 1.1e-09 38.0 1.0 1.6e-09 37.5 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_1 PF04997.7 EDK37010.1 - 5.5e-105 351.3 0.0 6.7e-105 351.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 Pro_isomerase PF00160.16 EDK37011.1 - 4.6e-45 153.5 0.2 7.5e-45 152.9 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 EDK37011.1 - 1e-10 41.0 2.7 2.7e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EDK37011.1 - 2.1e-06 27.1 6.5 0.00021 20.7 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK37011.1 - 1.7e-05 24.3 5.5 0.00029 20.5 0.3 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK37011.1 - 0.00028 20.7 3.7 0.0049 16.7 1.8 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.13 EDK37011.1 - 0.00083 19.1 1.6 0.072 12.9 0.9 2.6 2 1 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_8 PF13181.1 EDK37011.1 - 0.0071 16.0 3.0 0.076 12.8 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37011.1 - 0.079 13.6 1.7 0.6 10.8 0.1 2.7 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 EDK37011.1 - 0.088 13.4 0.5 0.4 11.4 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EDK37011.1 - 0.63 10.6 3.2 0.98 10.0 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 EDK37012.2 - 1.4e-59 201.3 0.1 1.7e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37012.2 - 8.9e-20 70.8 0.0 1.3e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK37012.2 - 1.8e-06 27.8 0.0 4.6e-06 26.5 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EDK37012.2 - 0.0028 17.2 0.2 0.0053 16.3 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase PucR PF07905.6 EDK37012.2 - 0.057 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family LTV PF04180.9 EDK37013.2 - 1.9e-71 241.8 37.7 3.2e-71 241.0 26.1 1.3 1 1 0 1 1 1 1 Low temperature viability protein HAMP PF00672.20 EDK37013.2 - 0.074 13.2 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 HAMP domain MatE PF01554.13 EDK37014.2 - 1.9e-57 193.4 33.6 3.7e-30 104.6 6.8 2.6 3 0 0 3 3 3 2 MatE PIH1 PF08190.7 EDK37015.2 - 1.6e-28 100.1 3.7 2e-28 99.8 2.2 1.4 1 1 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Ku_C PF03730.9 EDK37015.2 - 0.14 12.6 5.1 0.28 11.7 2.7 2.1 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm BPL_N PF09825.4 EDK37016.2 - 3.4e-136 453.8 0.1 4.9e-136 453.3 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.14 EDK37016.2 - 3.5e-13 49.6 0.0 7.1e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.12 EDK37016.2 - 2.3e-09 36.7 0.1 5.6e-09 35.5 0.1 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain zf-Apc11 PF12861.2 EDK37017.2 - 1.5e-43 146.5 8.0 1.9e-43 146.2 5.5 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EDK37017.2 - 1.1e-29 102.3 8.6 1.4e-29 101.9 6.0 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EDK37017.2 - 1.5e-07 31.0 14.3 9.9e-07 28.4 9.9 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EDK37017.2 - 6.6e-05 22.4 11.4 0.0002 20.9 7.9 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK37017.2 - 0.00044 20.1 10.0 0.003 17.5 6.9 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 EDK37017.2 - 0.0025 17.3 10.9 0.0064 16.0 0.6 2.7 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 EDK37017.2 - 0.0061 16.4 2.9 0.0061 16.4 2.0 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 EDK37017.2 - 0.1 12.2 11.8 2.3 7.9 8.2 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK37017.2 - 0.15 11.7 12.9 1.5 8.6 9.1 2.4 1 1 1 2 2 2 0 zinc-RING finger domain PHD PF00628.24 EDK37017.2 - 0.21 11.3 12.0 0.67 9.7 8.3 1.8 1 1 0 1 1 1 0 PHD-finger zf-HIT PF04438.11 EDK37017.2 - 0.29 10.8 6.8 0.13 11.9 1.8 2.1 2 0 0 2 2 2 0 HIT zinc finger DZR PF12773.2 EDK37017.2 - 0.83 9.5 9.3 99 2.8 6.5 2.3 1 1 0 1 1 1 0 Double zinc ribbon zf-HC5HC2H_2 PF13832.1 EDK37017.2 - 0.85 9.6 6.0 0.87 9.6 3.0 1.9 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING-like PF08746.6 EDK37017.2 - 1.4 9.0 12.1 8.1 6.5 8.4 2.2 1 1 0 1 1 1 0 RING-like domain zf-Nse PF11789.3 EDK37017.2 - 1.7 8.2 5.2 3.6 7.1 3.6 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 EDK37017.2 - 2.3 8.2 17.9 69 3.5 12.4 3.3 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 EDK37017.2 - 3.1 7.8 9.3 8.7 6.4 6.4 1.8 1 1 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.1 EDK37017.2 - 3.3 7.5 13.8 5.6 6.7 0.1 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 UbiA PF01040.13 EDK37018.2 - 2.4e-30 105.6 17.2 3e-30 105.2 11.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Lip_A_acyltrans PF03279.8 EDK37019.2 - 0.038 12.8 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase AA_kinase PF00696.23 EDK37021.2 - 1.6e-38 132.6 1.0 2.7e-38 131.9 0.7 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 EDK37021.2 - 1.4e-13 50.3 0.0 2.7e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 PUA domain SurE PF01975.12 EDK37022.1 - 9e-49 165.4 0.0 1.3e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE DUF2701 PF10857.3 EDK37023.2 - 0.067 12.9 0.1 7.7 6.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2701) Metallophos PF00149.23 EDK37024.2 - 1e-41 142.5 0.3 1.3e-41 142.2 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EDK37024.2 - 0.0021 17.9 0.0 0.003 17.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ribosomal_S18 PF01084.15 EDK37025.1 - 5.6e-20 70.9 0.0 1e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Herpes_US12 PF05363.7 EDK37025.1 - 0.21 12.0 1.0 2.7 8.5 0.0 2.4 2 1 0 2 2 2 0 Herpesvirus US12 family MFS_1 PF07690.11 EDK37026.2 - 9.2e-37 126.5 34.5 9.2e-37 126.5 23.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK37026.2 - 3.9e-12 45.4 26.2 1.3e-11 43.7 18.2 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter PI-PLC-X PF00388.14 EDK37026.2 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain HMGL-like PF00682.14 EDK37028.2 - 2.7e-74 249.7 0.2 3.2e-74 249.5 0.1 1.0 1 0 0 1 1 1 1 HMGL-like ADP_PFK_GK PF04587.10 EDK37028.2 - 0.016 13.4 0.0 0.022 13.0 0.0 1.1 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region EXS PF03124.9 EDK37029.2 - 1.4e-98 330.1 29.9 1.9e-98 329.7 20.7 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.14 EDK37029.2 - 5.8e-49 167.3 13.7 1.1e-48 166.3 9.5 1.5 1 0 0 1 1 1 1 SPX domain TauE PF01925.14 EDK37029.2 - 4.3 6.7 12.6 5.1 6.4 7.2 2.0 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE Abhydrolase_6 PF12697.2 EDK37030.2 - 1.1e-25 90.8 0.0 1.8e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK37030.2 - 3.6e-17 62.4 0.0 6.6e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DSPc PF00782.15 EDK37030.2 - 1e-12 47.7 0.0 6.6e-12 45.1 0.0 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Abhydrolase_1 PF00561.15 EDK37030.2 - 2.6e-11 43.5 0.0 6.1e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 EDK37030.2 - 5.7e-07 29.3 0.0 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein DUF2305 PF10230.4 EDK37030.2 - 1.9e-06 27.5 0.0 3.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Thioesterase PF00975.15 EDK37030.2 - 5.8e-06 26.6 0.0 0.00015 22.0 0.0 2.3 2 0 0 2 2 2 1 Thioesterase domain Ser_hydrolase PF06821.8 EDK37030.2 - 5.2e-05 22.9 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase DUF900 PF05990.7 EDK37030.2 - 0.00076 18.8 0.0 0.0014 17.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Esterase PF00756.15 EDK37030.2 - 0.0015 18.0 0.0 0.0032 16.9 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.8 EDK37030.2 - 0.0028 17.2 0.0 0.0064 16.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Y_phosphatase PF00102.22 EDK37030.2 - 0.0029 16.9 0.0 0.0066 15.8 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase BAAT_C PF08840.6 EDK37030.2 - 0.01 15.5 0.0 0.53 9.9 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DSPn PF14671.1 EDK37030.2 - 0.011 15.6 0.0 0.13 12.2 0.0 2.7 3 0 0 3 3 2 0 Dual specificity protein phosphatase, N-terminal half Abhydrolase_2 PF02230.11 EDK37030.2 - 0.013 14.9 0.1 0.082 12.3 0.0 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.2 EDK37030.2 - 0.024 13.5 0.1 0.055 12.3 0.0 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme LCAT PF02450.10 EDK37030.2 - 0.033 13.1 0.2 0.078 11.9 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DUF3530 PF12048.3 EDK37030.2 - 0.034 13.1 0.0 0.062 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF3089 PF11288.3 EDK37030.2 - 0.039 13.0 0.0 0.097 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Lipase_3 PF01764.20 EDK37030.2 - 0.06 12.9 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) DUF1057 PF06342.7 EDK37030.2 - 0.077 11.7 0.0 0.15 10.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Med11 PF10280.4 EDK37031.2 - 0.011 15.8 0.3 0.019 14.9 0.2 1.6 1 1 0 1 1 1 0 Mediator complex protein E1-E2_ATPase PF00122.15 EDK37032.2 - 1.1e-25 90.0 0.3 1.7e-25 89.3 0.2 1.3 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 EDK37032.2 - 0.027 14.6 0.1 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK37033.2 - 1.4e-08 35.4 0.0 3.4e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK37033.2 - 0.00028 21.0 0.1 0.0011 19.1 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK37033.2 - 0.0048 16.4 0.1 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribosomal_S4Pg PF11993.3 EDK37034.2 - 0.059 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Ribosomal S4P (gammaproteobacterial) ATP-synt_ab PF00006.20 EDK37035.1 - 1.3e-68 230.6 0.0 1.8e-68 230.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EDK37035.1 - 3.8e-27 94.9 0.5 3.8e-27 94.9 0.3 2.0 3 0 0 3 3 3 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EDK37035.1 - 3.1e-05 24.0 0.1 8e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_25 PF13481.1 EDK37035.1 - 0.029 13.7 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Alveol-reg_P311 PF11092.3 EDK37036.2 - 0.22 11.4 1.6 0.42 10.6 0.1 2.1 1 1 1 2 2 2 0 Neuronal protein 3.1 (p311) Macoilin PF09726.4 EDK37036.2 - 7.4 4.7 14.2 9.9 4.3 9.8 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_M1 PF01433.15 EDK37038.2 - 6e-141 470.0 0.3 1.1e-140 469.2 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EDK37038.2 - 7.4e-87 291.6 5.0 7.4e-87 291.6 3.4 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EDK37038.2 - 4.5e-18 65.5 0.1 1.1e-17 64.2 0.1 1.6 1 0 0 1 1 1 1 Peptidase MA superfamily Dynamin_M PF01031.15 EDK37039.2 - 1.7e-112 374.9 0.0 3e-112 374.2 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EDK37039.2 - 2.8e-54 183.4 1.3 5e-54 182.6 0.1 2.0 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 EDK37039.2 - 1.3e-27 95.4 4.4 3.3e-27 94.2 3.0 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EDK37039.2 - 0.0076 16.1 0.7 0.12 12.3 0.5 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK37039.2 - 0.017 14.4 0.2 4.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Miro PF08477.8 EDK37039.2 - 0.024 15.1 0.2 0.12 12.8 0.1 2.3 1 1 0 1 1 1 0 Miro-like protein ABC_tran PF00005.22 EDK37039.2 - 0.028 14.7 0.0 0.14 12.4 0.0 2.2 1 0 0 1 1 1 0 ABC transporter Saw1 PF11561.3 EDK37040.2 - 1.9e-51 174.5 6.1 2.1e-51 174.3 4.3 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 TRAPPC10 PF12584.3 EDK37040.2 - 0.014 14.9 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 Anp1 PF03452.9 EDK37041.2 - 1.3e-56 191.7 0.5 1.6e-56 191.4 0.3 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 EDK37041.2 - 0.0011 18.7 0.1 0.0023 17.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Mycobact_memb PF05423.8 EDK37041.2 - 0.015 15.0 0.0 0.048 13.3 0.0 1.8 2 0 0 2 2 2 0 Mycobacterium membrane protein Lentiviral_Tat PF02998.9 EDK37041.2 - 0.15 11.9 0.2 0.37 10.6 0.2 1.6 1 0 0 1 1 1 0 Lentiviral Tat protein KAT11 PF08214.6 EDK37042.2 - 6.6e-102 341.1 0.9 7.9e-102 340.8 0.6 1.0 1 0 0 1 1 1 1 Histone acetylation protein SpoVIF PF14069.1 EDK37042.2 - 0.11 12.1 0.4 0.55 10.0 0.0 2.2 2 1 0 2 2 2 0 Stage VI sporulation protein F DivIC PF04977.10 EDK37043.2 - 0.00024 20.5 7.7 0.0018 17.6 1.2 2.5 2 0 0 2 2 2 1 Septum formation initiator HALZ PF02183.13 EDK37043.2 - 0.00034 20.2 11.0 0.0015 18.2 3.0 2.4 2 0 0 2 2 2 1 Homeobox associated leucine zipper bZIP_1 PF00170.16 EDK37043.2 - 0.008 16.1 8.5 0.011 15.7 2.0 2.6 2 0 0 2 2 2 1 bZIP transcription factor Herpes_BLRF2 PF05812.7 EDK37043.2 - 0.043 13.6 6.9 1.4 8.7 1.0 2.3 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein TBPIP PF07106.8 EDK37043.2 - 0.053 13.0 7.1 1.4 8.4 0.7 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SPX PF03105.14 EDK37043.2 - 0.069 12.9 10.5 0.1 12.3 7.3 1.3 1 0 0 1 1 1 0 SPX domain DUF972 PF06156.8 EDK37043.2 - 0.083 13.2 8.6 0.19 12.1 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Cep57_CLD_2 PF14197.1 EDK37043.2 - 0.092 12.6 10.1 0.47 10.4 2.4 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Tup_N PF08581.5 EDK37043.2 - 0.12 12.5 2.5 1.4 9.1 0.1 2.3 2 0 0 2 2 2 0 Tup N-terminal bZIP_2 PF07716.10 EDK37043.2 - 0.13 12.1 14.8 0.58 10.0 3.0 2.6 2 0 0 2 2 2 0 Basic region leucine zipper DUF904 PF06005.7 EDK37043.2 - 0.17 12.2 11.8 0.34 11.2 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Kinesin-relat_1 PF12711.2 EDK37043.2 - 0.23 11.8 6.4 1.6 9.2 0.8 2.4 2 0 0 2 2 2 0 Kinesin motor DUF4140 PF13600.1 EDK37043.2 - 0.23 11.9 11.2 0.34 11.3 1.8 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TSC22 PF01166.13 EDK37043.2 - 0.24 11.3 5.0 0.29 11.1 0.4 2.6 2 1 0 2 2 2 0 TSC-22/dip/bun family DivIVA PF05103.8 EDK37043.2 - 0.38 10.7 10.2 1.4 8.9 1.2 2.5 1 1 0 1 1 1 0 DivIVA protein TMF_DNA_bd PF12329.3 EDK37043.2 - 0.53 10.1 8.4 5.3 6.9 1.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Kinetocho_Slk19 PF12709.2 EDK37043.2 - 0.67 10.0 6.2 2.7 8.1 0.5 2.4 2 0 0 2 2 2 0 Central kinetochore-associated DUF2681 PF10883.3 EDK37043.2 - 0.8 9.9 7.0 0.41 10.8 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Pox_A_type_inc PF04508.7 EDK37043.2 - 0.87 9.5 5.6 6.5 6.8 0.8 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Rabaptin PF03528.10 EDK37043.2 - 0.89 9.4 8.2 0.44 10.4 0.8 2.2 1 1 0 2 2 2 0 Rabaptin Rootletin PF15035.1 EDK37043.2 - 1.1 9.2 12.0 2 8.3 8.3 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion SlyX PF04102.7 EDK37043.2 - 1.5 9.2 7.7 0.3 11.4 0.4 2.5 2 0 0 2 2 2 0 SlyX bZIP_Maf PF03131.12 EDK37043.2 - 1.9 8.8 8.3 1.3 9.3 1.3 2.4 2 0 0 2 2 2 0 bZIP Maf transcription factor DUF1640 PF07798.6 EDK37043.2 - 2.9 7.9 11.9 28 4.6 6.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Vps51 PF08700.6 EDK37043.2 - 3.1 7.7 10.3 2.7 7.8 0.4 3.1 3 1 0 3 3 3 0 Vps51/Vps67 DUF3450 PF11932.3 EDK37043.2 - 3.1 7.0 9.4 1.8 7.7 1.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) AIP3 PF03915.8 EDK37043.2 - 3.3 6.5 14.9 0.64 8.8 6.8 1.9 1 1 1 2 2 2 0 Actin interacting protein 3 Wbp11 PF09429.5 EDK37043.2 - 3.4 7.7 8.2 4.9 7.1 0.8 2.4 2 0 0 2 2 2 0 WW domain binding protein 11 Bap31 PF05529.7 EDK37043.2 - 3.7 6.9 12.6 1.2 8.5 4.0 2.8 1 1 2 3 3 3 0 B-cell receptor-associated protein 31-like G-gamma PF00631.17 EDK37043.2 - 3.8 7.3 6.5 6.5 6.5 0.5 2.6 2 0 0 2 2 2 0 GGL domain MGC-24 PF05283.6 EDK37043.2 - 4.2 7.1 7.3 21 4.8 2.0 2.1 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24) DUF4613 PF15390.1 EDK37043.2 - 8 4.5 16.4 0.82 7.7 5.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4613) DUF4200 PF13863.1 EDK37043.2 - 10 6.1 14.9 3.6 7.5 2.1 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4200) Polysacc_deac_1 PF01522.16 EDK37044.2 - 5.2e-26 90.6 0.0 8.3e-26 90.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 EDK37044.2 - 0.0046 15.9 0.0 0.0067 15.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF1804 PF08822.6 EDK37045.2 - 0.0084 15.8 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) PhaP_Bmeg PF09602.5 EDK37045.2 - 0.086 12.6 1.6 1 9.1 0.1 2.3 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF2422 PF10337.4 EDK37045.2 - 0.11 11.2 0.2 0.16 10.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) NAP PF00956.13 EDK37046.2 - 4.9e-85 284.5 13.5 4.9e-85 284.5 9.3 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Prothymosin PF03247.9 EDK37046.2 - 6.8 6.8 54.3 0.81 9.8 12.6 3.3 3 0 0 3 3 3 0 Prothymosin/parathymosin family ABC_membrane_2 PF06472.10 EDK37047.2 - 5.3e-89 298.0 5.4 8.5e-89 297.4 3.8 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EDK37047.2 - 3.5e-20 72.7 0.0 1.1e-19 71.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.1 EDK37047.2 - 1.9e-06 28.3 4.4 1.2e-05 25.7 2.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 EDK37047.2 - 0.0026 17.0 1.9 1.4 8.0 0.0 3.0 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain ATP-synt_ab PF00006.20 EDK37047.2 - 0.0043 16.5 0.1 0.0088 15.5 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.24 EDK37047.2 - 0.017 15.2 0.1 0.074 13.2 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK37047.2 - 0.023 14.6 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.12 EDK37047.2 - 0.056 12.8 0.2 0.5 9.7 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.21 EDK37047.2 - 0.059 12.8 0.0 0.28 10.6 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.9 EDK37047.2 - 0.077 12.7 0.1 1 9.0 0.1 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EDK37047.2 - 0.082 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 EDK37047.2 - 0.098 12.4 0.0 0.62 9.8 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain CTP_transf_2 PF01467.21 EDK37048.1 - 2.7e-36 124.9 0.0 3.9e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase Aconitase PF00330.15 EDK37049.1 - 5.4e-193 641.7 0.0 6.6e-193 641.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EDK37049.1 - 1.4e-45 154.6 0.0 2.8e-45 153.6 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain APG5 PF04106.7 EDK37050.2 - 9.9e-48 162.2 0.2 1.2e-47 161.9 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 YjeF_N PF03853.10 EDK37052.1 - 2.1e-37 128.3 0.0 2.6e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Septin PF00735.13 EDK37053.2 - 2.2e-54 184.3 0.1 2.2e-54 184.3 0.1 2.2 2 0 0 2 2 2 1 Septin Synaptobrevin PF00957.16 EDK37053.2 - 0.081 12.5 1.2 0.23 11.0 0.8 1.8 1 0 0 1 1 1 0 Synaptobrevin HEAT_EZ PF13513.1 EDK37054.2 - 2.3e-16 59.7 27.6 3.4e-08 33.7 0.1 10.8 10 3 2 12 12 12 4 HEAT-like repeat HEAT PF02985.17 EDK37054.2 - 1.4e-14 52.7 22.3 0.0008 19.2 0.0 11.5 12 0 0 12 12 12 4 HEAT repeat IBN_N PF03810.14 EDK37054.2 - 3.8e-12 45.9 2.9 1e-11 44.6 1.4 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 EDK37054.2 - 2.6e-10 40.4 29.3 8.5e-06 25.9 0.0 7.2 3 1 4 7 7 7 4 HEAT repeats Arm PF00514.18 EDK37054.2 - 6.8e-07 28.8 8.1 0.006 16.3 0.1 6.3 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 EDK37054.2 - 0.00011 21.6 0.0 3.1 7.0 0.0 5.1 5 1 1 6 6 6 1 CLASP N terminal TIP120 PF08623.5 EDK37054.2 - 0.0045 16.5 0.4 0.05 13.1 0.0 2.9 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) PAP2 PF01569.16 EDK37055.2 - 2.9e-17 62.5 2.3 2.9e-17 62.5 1.6 1.4 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.9 EDK37055.2 - 0.12 12.1 2.4 2.4 7.9 0.3 2.3 1 1 1 2 2 2 0 Divergent PAP2 family YqhR PF11085.3 EDK37055.2 - 1.7 8.1 7.9 1.8 8.0 3.1 2.1 2 0 0 2 2 2 0 Conserved membrane protein YqhR ArfGap PF01412.13 EDK37056.2 - 4.9e-33 113.3 0.0 1e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf adh_short_C2 PF13561.1 EDK37057.2 - 6.3e-27 94.8 0.1 7.9e-27 94.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK37057.2 - 8.6e-22 77.8 2.8 1.1e-21 77.4 1.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK37057.2 - 1.7e-09 37.6 0.7 2.4e-09 37.1 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK37057.2 - 0.054 12.9 0.2 0.077 12.4 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2209 PF09974.4 EDK37057.2 - 0.11 12.5 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) SMK-1 PF04802.10 EDK37058.2 - 8.7e-41 139.5 1.9 8.7e-41 139.5 1.3 3.0 3 0 0 3 3 3 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.18 EDK37058.2 - 0.0019 17.9 0.0 0.004 16.8 0.0 1.5 1 0 0 1 1 1 1 WH1 domain HEAT_2 PF13646.1 EDK37058.2 - 0.036 14.3 0.1 6.3 7.1 0.0 3.0 3 0 0 3 3 3 0 HEAT repeats DUF2435 PF10363.4 EDK37058.2 - 0.15 12.0 1.6 0.57 10.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2435) ATP12 PF07542.6 EDK37059.2 - 8.1e-33 112.9 0.0 1.2e-32 112.4 0.0 1.2 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.15 EDK37060.2 - 2.1e-09 37.0 4.1 2.6e-09 36.7 2.8 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF3984 PF13136.1 EDK37060.2 - 0.079 12.1 0.1 0.09 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Tropomyosin_1 PF12718.2 EDK37060.2 - 2.5 7.9 7.7 2.9 7.7 1.8 2.0 1 1 1 2 2 2 0 Tropomyosin like Gon7 PF08738.5 EDK37061.1 - 5.3e-34 116.3 0.0 5.8e-34 116.1 0.0 1.0 1 0 0 1 1 1 1 Gon7 family 6PF2K PF01591.13 EDK37062.2 - 1.1e-59 201.1 0.2 1.7e-59 200.6 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EDK37062.2 - 4e-16 59.5 0.0 1e-15 58.1 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_17 PF13207.1 EDK37062.2 - 0.00044 21.0 0.0 0.0011 19.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EDK37062.2 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK37062.2 - 0.016 15.5 0.0 0.044 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 EDK37062.2 - 0.018 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF1702 PF08012.6 EDK37062.2 - 0.04 12.5 0.0 0.15 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1702) IstB_IS21 PF01695.12 EDK37062.2 - 0.073 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.1 EDK37062.2 - 0.12 12.1 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain KOW PF00467.24 EDK37063.1 - 0.0037 16.9 1.3 0.0061 16.2 0.1 1.9 2 1 0 3 3 3 1 KOW motif TIM21 PF08294.6 EDK37064.1 - 5.4e-44 149.3 0.0 6.6e-44 149.0 0.0 1.1 1 0 0 1 1 1 1 TIM21 Mito_fiss_reg PF05308.6 EDK37064.1 - 0.047 13.0 0.6 0.065 12.5 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 EDK37064.1 - 1.1 8.4 2.9 1.6 7.9 2.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Arf PF00025.16 EDK37066.2 - 1.6e-54 183.7 3.6 1.8e-54 183.6 2.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK37066.2 - 1.4e-14 53.7 0.2 1.7e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 EDK37066.2 - 9.3e-12 44.6 0.2 1.2e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EDK37066.2 - 2.9e-10 39.3 5.3 1.2e-06 27.5 1.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.22 EDK37066.2 - 8.6e-09 35.0 0.1 1.6e-08 34.2 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 EDK37066.2 - 3.9e-07 29.4 0.0 5e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EDK37066.2 - 5.6e-07 29.5 0.0 8.1e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK37066.2 - 1.7e-06 28.4 0.0 3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein cobW PF02492.14 EDK37066.2 - 0.00062 19.2 0.1 0.002 17.6 0.1 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CdhD PF03599.11 EDK37066.2 - 0.032 12.7 0.0 0.042 12.3 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit FeoB_N PF02421.13 EDK37066.2 - 0.12 11.5 3.2 2.2 7.5 2.2 2.5 1 1 0 1 1 1 0 Ferrous iron transport protein B TAF8_C PF10406.4 EDK37066.2 - 0.14 12.1 0.2 0.34 11.0 0.2 1.6 1 0 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term DRMBL PF07522.9 EDK37067.2 - 3.5e-21 75.3 0.0 1.1e-20 73.7 0.0 1.8 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 EDK37067.2 - 2.8e-06 27.0 0.1 5.1e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 EDK37067.2 - 0.0087 15.7 4.4 0.089 12.4 3.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Glyco_transf_34 PF05637.7 EDK37068.2 - 2.9e-49 167.7 0.5 4.3e-49 167.1 0.4 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF1751 PF08551.5 EDK37069.2 - 1.9e-27 95.4 5.1 4.7e-27 94.2 3.6 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 EDK37069.2 - 0.055 13.4 11.3 0.015 15.2 5.8 1.5 2 0 0 2 2 2 0 Rhomboid family Phageshock_PspG PF09583.5 EDK37069.2 - 2.3 8.3 7.1 0.32 11.0 0.4 2.7 2 0 0 2 2 2 0 Phage shock protein G (Phageshock_PspG) Glucan_synthase PF02364.10 EDK37070.2 - 0 1408.0 0.0 0 1406.8 0.0 1.6 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EDK37070.2 - 2.2e-36 124.2 1.8 3.2e-36 123.7 0.1 2.2 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 eIF2A PF08662.6 EDK37071.2 - 3.2e-45 154.2 0.0 4.4e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A CDV3 PF15359.1 EDK37071.2 - 0.14 12.2 0.4 0.14 12.2 0.3 2.4 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 OTU PF02338.14 EDK37072.2 - 1.1e-09 38.9 0.0 2.1e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease EAF PF09816.4 EDK37072.2 - 0.083 12.8 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription elongation factor Ribosomal_L16 PF00252.13 EDK37073.1 - 4.8e-32 110.4 0.1 6.2e-32 110.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PMM PF03332.8 EDK37074.1 - 3.3e-113 376.6 0.7 3.8e-113 376.5 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 EDK37074.1 - 9.1e-06 25.4 0.0 3.7e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 EDK37074.1 - 0.018 14.3 0.0 0.46 9.7 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase RCC1 PF00415.13 EDK37075.2 - 1.8e-26 92.1 0.4 1.3e-06 28.5 0.1 6.5 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 EDK37075.2 - 1.3e-20 72.4 7.4 1e-09 37.7 0.6 4.6 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat TNV_CP PF03898.8 EDK37075.2 - 0.1 11.6 0.0 0.23 10.4 0.0 1.5 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF1640 PF07798.6 EDK37076.2 - 2.2e-66 223.2 5.6 2.4e-66 223.1 3.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) ADIP PF11559.3 EDK37076.2 - 0.0059 16.5 7.5 0.081 12.8 1.3 2.2 2 0 0 2 2 2 2 Afadin- and alpha -actinin-Binding Tmemb_cc2 PF10267.4 EDK37076.2 - 0.014 13.9 4.6 0.018 13.6 3.2 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF3158 PF11358.3 EDK37076.2 - 0.02 14.4 0.8 0.02 14.4 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3158) Uds1 PF15456.1 EDK37076.2 - 0.027 14.4 7.4 0.044 13.7 5.1 1.3 1 0 0 1 1 1 0 Up-regulated During Septation Prominin PF05478.6 EDK37076.2 - 0.027 12.0 1.0 0.032 11.7 0.7 1.2 1 0 0 1 1 1 0 Prominin HalX PF08663.5 EDK37076.2 - 0.038 13.9 1.5 2 8.4 0.1 2.4 2 0 0 2 2 2 0 HalX domain FlaC_arch PF05377.6 EDK37076.2 - 0.038 13.8 4.3 1.7 8.5 0.4 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HALZ PF02183.13 EDK37076.2 - 0.053 13.2 5.5 0.14 11.8 2.9 2.3 2 1 0 2 2 2 0 Homeobox associated leucine zipper Kinesin-related PF06548.6 EDK37076.2 - 0.069 11.7 6.7 0.081 11.4 4.6 1.1 1 0 0 1 1 1 0 Kinesin-related UPF0449 PF15136.1 EDK37076.2 - 0.07 13.3 0.6 0.07 13.3 0.4 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF342 PF03961.8 EDK37076.2 - 0.11 10.9 7.8 0.14 10.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Inhibitor_I69 PF13734.1 EDK37076.2 - 0.12 12.5 0.2 5.7 7.1 0.0 2.6 2 1 1 3 3 3 0 Spi protease inhibitor Phage_lysis PF03245.8 EDK37076.2 - 0.19 11.7 3.9 0.63 10.0 2.7 1.8 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein IncA PF04156.9 EDK37076.2 - 0.19 11.2 8.6 2.2 7.8 1.4 2.2 1 1 1 2 2 2 0 IncA protein Mnd1 PF03962.10 EDK37076.2 - 0.28 10.8 9.4 0.38 10.4 6.5 1.3 1 1 0 1 1 1 0 Mnd1 family Ded_cyto PF06920.8 EDK37076.2 - 0.32 10.2 4.8 0.14 11.4 0.8 1.9 1 1 1 2 2 2 0 Dedicator of cytokinesis TraC PF07820.7 EDK37076.2 - 0.47 10.6 2.9 14 5.9 0.3 2.4 2 0 0 2 2 2 0 TraC-like protein DivIC PF04977.10 EDK37076.2 - 0.89 9.0 8.9 4.1 6.9 2.9 2.7 2 1 0 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.15 EDK37076.2 - 0.94 9.2 9.8 4.4 7.1 2.2 2.6 2 1 0 2 2 2 0 Prefoldin subunit SlyX PF04102.7 EDK37076.2 - 1.1 9.7 5.2 13 6.2 0.2 2.9 2 1 1 3 3 3 0 SlyX Baculo_PEP_C PF04513.7 EDK37076.2 - 2 8.2 8.5 4.5 7.0 3.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF972 PF06156.8 EDK37076.2 - 2.5 8.4 8.5 3.3 8.0 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) FliD_N PF02465.13 EDK37076.2 - 2.9 8.2 7.2 2.1 8.7 1.1 2.8 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Syntaxin PF00804.20 EDK37076.2 - 5.6 7.1 12.1 1.1 9.4 2.9 2.3 1 1 1 2 2 2 0 Syntaxin V-SNARE_C PF12352.3 EDK37077.2 - 3.7e-14 52.5 1.3 3.7e-14 52.5 0.9 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 EDK37077.2 - 3.4e-09 36.2 0.8 2.1e-08 33.7 0.0 2.3 2 1 1 3 3 3 1 Sec20 Sigma70_r4 PF04545.11 EDK37077.2 - 0.0019 17.5 0.3 0.0041 16.3 0.1 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 DUF607 PF04678.8 EDK37077.2 - 0.013 15.4 3.6 1.1 9.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF607 DUF4047 PF13256.1 EDK37077.2 - 0.023 14.6 3.2 0.9 9.5 0.1 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4047) DUF948 PF06103.6 EDK37077.2 - 0.068 13.0 1.5 9.4 6.1 0.1 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Lge1 PF11488.3 EDK37077.2 - 0.34 11.1 2.3 0.58 10.3 0.4 2.3 2 2 0 2 2 2 0 Transcriptional regulatory protein LGE1 CENP-Q PF13094.1 EDK37077.2 - 0.47 10.4 8.1 0.87 9.5 5.6 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DASH_Duo1 PF08651.5 EDK37077.2 - 0.64 9.6 3.4 6 6.5 0.1 2.7 3 0 0 3 3 3 0 DASH complex subunit Duo1 TPR_MLP1_2 PF07926.7 EDK37077.2 - 0.9 9.2 7.8 6.3 6.5 5.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein APG6 PF04111.7 EDK37077.2 - 2.9 6.8 7.7 6.9 5.6 4.1 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF972 PF06156.8 EDK37077.2 - 4.3 7.7 7.4 21 5.5 3.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Glyco_hydro_17 PF00332.13 EDK37078.2 - 9.3e-08 31.4 2.1 4.7e-07 29.1 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 TSP9 PF11493.3 EDK37078.2 - 0.53 10.8 11.3 0.39 11.3 2.0 3.2 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 Bromodomain PF00439.20 EDK37079.2 - 4.3e-29 100.2 0.6 1.8e-15 56.6 0.2 2.7 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 EDK37079.2 - 3.9e-17 62.0 0.0 7.6e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 BAH domain SIR2 PF02146.12 EDK37080.2 - 4.5e-41 140.5 0.0 7.7e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Sir2 family Pyr_redox_dim PF02852.17 EDK37082.2 - 3.6e-42 142.8 0.1 9.2e-42 141.5 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 EDK37082.2 - 6.1e-39 133.9 12.4 1.1e-36 126.6 8.6 3.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK37082.2 - 4.7e-19 68.5 12.7 1.1e-18 67.3 1.7 3.4 4 0 0 4 4 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EDK37082.2 - 1.9e-12 46.7 5.7 6.1e-11 41.8 0.9 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 EDK37082.2 - 4.3e-10 40.0 1.0 9.2e-05 22.5 0.1 2.7 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK37082.2 - 3.2e-09 36.6 2.4 0.00069 19.5 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.2 EDK37082.2 - 8.5e-09 34.9 8.7 5.8e-08 32.2 0.1 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 EDK37082.2 - 8.8e-07 28.2 2.8 0.00074 18.6 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.19 EDK37082.2 - 1.3e-06 27.5 11.1 4e-06 25.9 0.5 3.8 3 1 1 4 4 4 1 FAD binding domain FAD_binding_3 PF01494.14 EDK37082.2 - 1.4e-05 24.3 8.3 0.06 12.4 2.0 3.4 2 1 0 2 2 2 2 FAD binding domain HI0933_like PF03486.9 EDK37082.2 - 1.4e-05 23.7 10.7 0.0021 16.6 0.3 4.0 3 1 0 4 4 4 2 HI0933-like protein DAO PF01266.19 EDK37082.2 - 2e-05 23.6 16.7 0.028 13.3 1.2 3.4 2 2 1 3 3 3 3 FAD dependent oxidoreductase K_oxygenase PF13434.1 EDK37082.2 - 3.7e-05 22.7 0.1 0.13 11.1 0.0 2.4 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.13 EDK37082.2 - 0.0029 17.2 0.9 0.0029 17.2 0.6 2.5 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EDK37082.2 - 0.0038 16.8 0.7 0.024 14.1 0.1 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 EDK37082.2 - 0.029 13.3 2.2 0.62 8.9 0.0 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Amino_oxidase PF01593.19 EDK37082.2 - 0.077 12.0 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK37082.2 - 0.21 10.9 3.5 0.067 12.5 0.3 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.1 EDK37082.2 - 0.31 11.3 3.0 20 5.5 0.2 3.6 3 1 0 3 3 3 0 Putative NAD(P)-binding F420_oxidored PF03807.12 EDK37082.2 - 0.37 11.2 3.4 4.5 7.7 2.3 2.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pmp3 PF01679.12 EDK37083.1 - 2.5e-24 84.7 4.3 2.7e-24 84.5 3.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator tRNA-synt_2d PF01409.15 EDK37084.1 - 3.2e-88 295.0 0.0 4.4e-88 294.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 EDK37084.1 - 3.3e-06 26.8 0.0 4.7e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 EDK37084.1 - 5.1e-05 22.2 0.1 0.0015 17.4 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_His PF13393.1 EDK37084.1 - 0.11 11.5 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Histidyl-tRNA synthetase zf-H2C2_2 PF13465.1 EDK37085.2 - 4.4e-06 26.7 0.5 4.4e-06 26.7 0.4 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EDK37085.2 - 0.00048 20.3 1.1 0.22 11.9 0.0 3.4 3 0 0 3 3 3 1 Zinc finger, C2H2 type Sina PF03145.11 EDK37085.2 - 0.019 14.6 2.2 0.079 12.6 0.1 2.1 1 1 1 2 2 2 0 Seven in absentia protein family zf-H2C2_5 PF13909.1 EDK37085.2 - 0.027 14.6 1.5 28 5.1 0.0 4.2 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.1 EDK37085.2 - 0.46 10.9 5.3 0.47 10.9 0.0 3.3 4 0 0 4 4 4 0 C2H2-type zinc finger Fcf2 PF08698.6 EDK37086.2 - 3.7e-33 113.4 1.4 6.3e-33 112.7 0.1 1.9 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Fib_alpha PF08702.5 EDK37088.2 - 0.061 13.4 7.9 0.13 12.3 4.2 2.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SlyX PF04102.7 EDK37088.2 - 0.091 13.1 4.6 0.36 11.2 0.2 3.2 2 0 0 2 2 2 0 SlyX CAP_GLY PF01302.20 EDK37089.2 - 2.3e-17 62.4 0.5 3.7e-17 61.7 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF745 PF05335.8 EDK37089.2 - 0.0053 16.3 9.9 0.0053 16.3 6.9 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF745) PspB PF06667.7 EDK37089.2 - 0.037 13.9 1.6 0.037 13.9 1.1 2.3 2 0 0 2 2 2 0 Phage shock protein B NPV_P10 PF05531.7 EDK37089.2 - 0.11 12.8 3.6 4 7.7 0.7 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-CCHC PF00098.18 EDK37089.2 - 0.26 11.2 1.1 0.51 10.3 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Matrilin_ccoil PF10393.4 EDK37089.2 - 0.48 9.8 4.6 0.72 9.2 2.0 2.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF641 PF04859.7 EDK37089.2 - 0.52 10.0 16.3 1.9 8.2 3.2 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) PilJ PF13675.1 EDK37089.2 - 0.64 10.3 12.2 0.85 9.9 1.3 2.4 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term RPW8 PF05659.6 EDK37089.2 - 0.8 9.2 8.6 0.39 10.2 1.3 2.2 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Tropomyosin_1 PF12718.2 EDK37089.2 - 3.1 7.6 34.0 3.5 7.4 10.1 2.4 1 1 1 2 2 2 0 Tropomyosin like Fib_alpha PF08702.5 EDK37089.2 - 4.2 7.4 15.1 0.2 11.7 4.8 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF948 PF06103.6 EDK37089.2 - 4.3 7.2 7.6 5.2 6.9 2.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Glutaredoxin2_C PF04399.8 EDK37089.2 - 5 6.7 10.0 7.8 6.0 0.9 2.3 1 1 0 2 2 2 0 Glutaredoxin 2, C terminal domain TMF_DNA_bd PF12329.3 EDK37089.2 - 5.1 6.9 25.3 5.6 6.8 5.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 EDK37089.2 - 9 5.1 27.6 0.52 9.2 8.6 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 SlyX PF04102.7 EDK37089.2 - 9.6 6.6 16.2 5.3 7.4 2.5 2.7 1 1 1 2 2 2 0 SlyX PhzC-PhzF PF02567.11 EDK37090.2 - 3.9e-66 223.1 0.0 4.4e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.6 EDK37090.2 - 7.5e-07 28.2 0.0 1.7e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Proline racemase FMN_dh PF01070.13 EDK37091.2 - 2.3e-91 306.3 0.0 4e-91 305.5 0.0 1.3 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EDK37091.2 - 1e-19 70.0 0.0 3.8e-19 68.2 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EDK37091.2 - 0.00016 20.7 0.0 0.00026 20.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Git3 PF11710.3 EDK37092.2 - 7.4e-74 247.6 17.8 8.9e-74 247.4 12.3 1.1 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 TauD PF02668.11 EDK37093.2 - 3.4e-52 177.6 0.1 4.8e-52 177.1 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sulfatase PF00884.18 EDK37094.1 - 3.5e-64 216.9 0.0 5.9e-64 216.1 0.0 1.4 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.12 EDK37094.1 - 0.0018 16.8 0.0 0.0025 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase_C PF14707.1 EDK37094.1 - 0.041 14.1 0.0 0.34 11.1 0.0 2.2 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase Phosphodiest PF01663.17 EDK37094.1 - 0.046 13.0 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase ACOX PF01756.14 EDK37095.2 - 2.1e-47 160.9 0.0 3.8e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 EDK37095.2 - 1.4e-17 62.9 1.0 2.6e-17 62.0 0.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 EDK37095.2 - 2.8e-16 59.9 0.1 6.3e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 EDK37095.2 - 0.0021 18.1 0.1 0.0091 16.1 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Claudin_2 PF13903.1 EDK37096.2 - 3.2e-05 23.6 3.8 0.0053 16.4 1.4 2.1 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.15 EDK37096.2 - 0.0022 17.6 1.9 0.0022 17.6 1.3 2.0 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Fig1 PF12351.3 EDK37096.2 - 0.026 14.4 5.9 0.044 13.6 2.4 2.1 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 ATAD4 PF15321.1 EDK37096.2 - 0.055 14.4 1.4 0.17 12.8 0.0 2.4 3 0 0 3 3 3 0 ATPase family AAA domain containing 4 DUF4064 PF13273.1 EDK37096.2 - 0.064 13.3 4.3 4.7 7.3 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) DUF2976 PF11190.3 EDK37096.2 - 0.17 11.4 1.9 0.66 9.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) DUF3753 PF12575.3 EDK37096.2 - 0.4 10.5 2.0 1.3 8.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3753) DUF805 PF05656.9 EDK37096.2 - 0.75 9.6 3.8 12 5.7 0.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF805) DUF2975 PF11188.3 EDK37096.2 - 4.3 7.0 9.5 18 5.0 4.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) adh_short PF00106.20 EDK37097.2 - 7.2e-16 58.5 0.0 1e-15 58.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK37097.2 - 3.1e-09 36.7 0.1 4.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK37097.2 - 3.2e-06 26.7 0.0 5.6e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 EDK37097.2 - 5.5e-06 26.3 0.0 9.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EDK37097.2 - 5.7e-06 26.4 0.1 1.6e-05 24.9 0.1 1.8 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_7 PF13241.1 EDK37097.2 - 0.0094 16.1 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding NmrA PF05368.8 EDK37097.2 - 0.019 14.1 0.1 0.029 13.6 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.10 EDK37097.2 - 0.065 12.1 0.1 0.09 11.6 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 EDK37097.2 - 0.077 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 EDK37097.2 - 0.15 11.2 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans_2 PF11951.3 EDK37098.2 - 4.9e-50 170.2 2.8 6.4e-50 169.8 1.9 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37098.2 - 4.6e-07 29.6 10.8 1e-06 28.5 7.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.10 EDK37099.2 - 6.5e-74 249.0 37.7 7.5e-74 248.8 26.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MatE PF01554.13 EDK37100.2 - 6.7e-48 162.3 35.5 2.3e-26 92.3 7.2 2.7 3 0 0 3 3 3 2 MatE Tic20 PF09685.5 EDK37100.2 - 0.0043 17.0 1.3 0.0043 17.0 0.9 3.8 3 1 0 3 3 3 1 Tic20-like protein Arginase PF00491.16 EDK37101.2 - 2e-33 115.8 0.0 2.6e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 EDK37101.2 - 0.1 12.8 0.2 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 UPF0489 domain Arginase PF00491.16 EDK37102.2 - 1.4e-40 139.3 0.0 1.7e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family Hyphal_reg_CWP PF11765.3 EDK37104.2 - 8.7e-104 346.8 18.7 2.1e-103 345.6 13.0 1.7 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Zn_Tnp_IS1595 PF12760.2 EDK37104.2 - 1.3e-05 24.8 20.1 12 5.7 0.0 9.2 9 0 0 9 9 9 1 Transposase zinc-ribbon domain DUF3039 PF11238.3 EDK37104.2 - 0.053 12.9 33.4 5.6 6.4 0.0 9.3 10 0 0 10 10 10 0 Protein of unknown function (DUF3039) LRR_1 PF00560.28 EDK37106.2 - 0.052 13.5 0.4 79 3.8 0.0 4.3 3 1 1 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.2 EDK37107.2 - 2.1e-05 24.0 9.6 0.056 13.0 0.3 5.7 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK37107.2 - 0.076 13.1 0.3 9 6.7 0.1 3.6 2 0 0 2 2 2 0 Leucine Rich repeat F-box-like PF12937.2 EDK37107.2 - 0.16 11.7 1.2 0.43 10.3 0.1 2.3 2 0 0 2 2 2 0 F-box-like LRR_1 PF00560.28 EDK37107.2 - 0.56 10.4 9.0 11 6.4 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 EDK37107.2 - 0.87 10.0 15.5 15 6.3 0.1 6.7 7 0 0 7 7 7 0 Leucine rich repeat LRR_8 PF13855.1 EDK37107.2 - 9.6 6.0 16.4 0.56 10.0 0.8 5.4 4 1 0 5 5 5 0 Leucine rich repeat LRR_4 PF12799.2 EDK37108.2 - 5.1e-08 32.3 24.0 0.79 9.4 0.2 10.0 7 3 3 10 10 10 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK37108.2 - 1.4e-06 27.5 16.8 7.8 6.9 0.1 10.1 9 3 2 11 11 11 3 Leucine Rich Repeat LRR_8 PF13855.1 EDK37108.2 - 1.1e-05 25.0 15.5 0.55 10.0 0.5 7.5 4 2 6 10 10 10 6 Leucine rich repeat LRR_6 PF13516.1 EDK37108.2 - 0.00048 19.9 13.2 1.4 9.2 0.0 8.1 5 2 3 8 8 8 1 Leucine Rich repeat LRR_7 PF13504.1 EDK37108.2 - 0.0016 18.2 19.9 23 5.7 0.1 10.1 11 1 1 12 12 12 1 Leucine rich repeat FNIP PF05725.7 EDK37108.2 - 0.0023 17.8 12.2 0.3 11.0 0.0 5.6 6 0 0 6 6 6 2 FNIP Repeat ATG22 PF11700.3 EDK37109.2 - 3e-127 425.0 26.3 3.4e-127 424.8 18.2 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like BT1 PF03092.11 EDK37109.2 - 0.00053 18.8 5.9 0.00053 18.8 4.1 1.5 2 0 0 2 2 2 1 BT1 family MFS_1 PF07690.11 EDK37110.2 - 2.1e-40 138.5 32.0 2.1e-40 138.5 22.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK37110.2 - 4.9e-16 58.3 23.9 5.4e-14 51.6 16.6 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EDK37110.2 - 0.002 16.4 1.4 0.002 16.4 0.9 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OPT PF03169.10 EDK37111.2 - 7.8e-179 596.0 42.6 8.9e-179 595.8 29.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Cation_ATPase_C PF00689.16 EDK37112.2 - 1.7 8.1 13.6 0.55 9.7 1.8 2.2 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus Toxin_YhaV PF11663.3 EDK37113.2 - 6.8 6.4 6.8 8.7 6.0 1.6 2.3 2 0 0 2 2 2 0 Toxin with endonuclease activity YhaV FMO-like PF00743.14 EDK37114.2 - 1.3e-32 112.7 0.3 5.6e-17 61.1 0.0 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EDK37114.2 - 4.9e-15 56.1 0.0 1e-13 51.8 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK37114.2 - 1.8e-08 34.3 0.0 9.7e-07 28.6 0.0 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 EDK37114.2 - 3.2e-08 32.8 0.4 2.9e-06 26.4 0.0 2.7 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EDK37114.2 - 8.6e-08 32.2 0.0 1.3e-05 25.2 0.0 2.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK37114.2 - 3.6e-06 26.8 0.0 8.8e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EDK37114.2 - 0.0048 16.0 0.0 0.021 13.9 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.22 EDK37114.2 - 0.014 15.7 0.0 0.15 12.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK37114.2 - 0.1 11.0 0.1 0.36 9.2 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.2 EDK37114.2 - 0.17 10.8 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase MFS_1 PF07690.11 EDK37115.2 - 8.1e-20 70.8 30.5 8.1e-20 70.8 21.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Hyphal_reg_CWP PF11765.3 EDK37116.2 - 5.5e-104 347.5 16.2 6.9e-104 347.1 11.2 1.0 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Sugar_tr PF00083.19 EDK37117.1 - 4.9e-95 318.7 27.9 5.6e-95 318.5 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37117.1 - 5.6e-24 84.5 52.6 4.8e-20 71.5 18.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM51 PF15345.1 EDK37117.1 - 0.16 11.6 0.9 6.3 6.4 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 Fungal_trans_2 PF11951.3 EDK37118.2 - 2.6e-19 69.1 3.0 9.4e-19 67.2 2.1 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37118.2 - 7.7e-07 28.9 11.4 1.3e-06 28.1 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transketolase_N PF00456.16 EDK37119.2 - 4.1e-121 403.8 0.0 6.2e-121 403.2 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 EDK37119.2 - 4.9e-43 146.6 0.0 8.2e-43 145.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.1 EDK37119.2 - 4.1e-10 39.0 0.0 7.9e-07 28.2 0.0 2.3 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.15 EDK37119.2 - 2.3e-05 24.3 0.0 5.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.15 EDK37119.2 - 0.00018 20.3 0.0 0.00031 19.5 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component ADH_N PF08240.7 EDK37120.2 - 1.3e-30 105.3 1.8 2.5e-30 104.4 1.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK37120.2 - 8.1e-13 48.0 0.0 1.3e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK37120.2 - 0.0034 18.2 0.0 0.0069 17.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Hyphal_reg_CWP PF11765.3 EDK37121.2 - 1.9e-107 358.9 17.3 4.4e-107 357.6 12.0 1.7 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.1 EDK37121.2 - 2.2e-14 53.3 19.6 2.2e-14 53.3 13.6 15.3 5 3 8 13 13 13 1 Flocculin type 3 repeat FTP PF07504.8 EDK37121.2 - 0.0001 21.7 30.6 17 4.9 0.1 11.0 10 0 0 10 10 10 4 Fungalysin/Thermolysin Propeptide Motif Serglycin PF04360.7 EDK37121.2 - 1.1 9.0 20.7 21 4.8 14.2 3.2 1 1 0 1 1 1 0 Serglycin Cro PF09048.5 EDK37121.2 - 4.8 6.8 28.3 1.4e+02 2.2 0.1 11.1 10 4 4 14 14 14 0 Cro PTR2 PF00854.16 EDK37122.1 - 3.1e-53 180.8 19.8 3.1e-53 180.8 13.7 1.6 2 0 0 2 2 2 1 POT family Fig1 PF12351.3 EDK37123.2 - 0.018 14.9 2.9 0.018 14.9 2.0 2.3 3 0 0 3 3 3 0 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 EDK37124.2 - 2.6e-08 33.6 5.7 4.8e-08 32.8 4.0 1.4 1 1 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EDK37124.2 - 0.00016 21.5 9.5 0.00017 21.5 4.6 2.1 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF3650 PF12368.3 EDK37124.2 - 0.025 14.0 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3650) Pcc1 PF09341.5 EDK37125.1 - 6.2e-23 80.6 0.1 6.8e-23 80.5 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 Pho86 PF11124.3 EDK37125.1 - 0.0039 16.2 0.0 0.0043 16.0 0.0 1.1 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 Methyltransf_28 PF02636.12 EDK37127.2 - 4.6e-34 117.9 0.0 6.4e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MFS_1 PF07690.11 EDK37128.2 - 2.4e-05 23.2 2.6 3.2e-05 22.8 1.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily XRN_N PF03159.13 EDK37129.2 - 9.8e-81 270.6 0.0 9.8e-81 270.6 0.0 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus DAGK_cat PF00781.19 EDK37130.2 - 4.3e-12 45.5 0.0 6.4e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF3414 PF11894.3 EDK37131.2 - 0 1581.8 57.5 0 1581.6 39.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) SnoaL_4 PF13577.1 EDK37132.2 - 2.1e-20 72.9 0.0 2.4e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.1 EDK37132.2 - 0.073 13.1 0.0 0.11 12.4 0.0 1.3 1 1 0 1 1 1 0 SnoaL-like domain AA_permease PF00324.16 EDK37133.1 - 1.2e-101 340.4 38.8 1.5e-101 340.1 26.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK37133.1 - 4.4e-16 58.4 42.6 6.6e-16 57.8 29.5 1.3 1 0 0 1 1 1 1 Amino acid permease PIN_4 PF13638.1 EDK37134.2 - 6.8e-13 48.8 0.0 1.3e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 PIN domain Ribosomal_L40e PF01020.12 EDK37136.1 - 1.3e-31 107.8 11.3 1.4e-31 107.7 7.8 1.0 1 0 0 1 1 1 1 Ribosomal L40e family zf-DHHC PF01529.15 EDK37136.1 - 0.53 9.6 4.2 0.58 9.5 2.9 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase zinc_ribbon_2 PF13240.1 EDK37136.1 - 2.6 7.6 5.4 2.3 7.7 0.1 2.4 3 0 0 3 3 3 0 zinc-ribbon domain IncA PF04156.9 EDK37137.2 - 0.05 13.2 21.3 0.076 12.6 14.7 1.2 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.10 EDK37137.2 - 0.12 12.0 14.2 0.14 11.8 9.3 1.5 1 1 0 1 1 1 0 Mnd1 family DUF4094 PF13334.1 EDK37137.2 - 1.1 9.7 14.6 2.9 8.3 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) CENP-F_leu_zip PF10473.4 EDK37137.2 - 1.1 9.1 19.5 1.4 8.7 12.7 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FemAB PF02388.11 EDK37137.2 - 2.1 6.9 7.5 3.2 6.3 5.2 1.3 1 0 0 1 1 1 0 FemAB family SlyX PF04102.7 EDK37137.2 - 5.8 7.3 18.3 1.7 9.1 3.9 3.5 3 1 1 4 4 4 0 SlyX HalX PF08663.5 EDK37137.2 - 7 6.7 11.8 7.1 6.6 3.7 2.6 1 1 1 2 2 2 0 HalX domain TPR_MLP1_2 PF07926.7 EDK37138.2 - 4.2e-07 29.7 20.3 4.2e-07 29.7 14.1 14.6 3 3 7 12 12 12 5 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.4 EDK37138.2 - 0.0034 17.2 17.2 0.0034 17.2 11.9 11.8 4 1 8 12 12 12 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sugar_tr PF00083.19 EDK37139.2 - 9e-82 275.0 22.0 1.1e-81 274.7 15.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37139.2 - 1.7e-16 59.9 22.5 3.6e-15 55.5 12.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily p450 PF00067.17 EDK37140.2 - 3.4e-64 217.0 0.0 4.1e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PEPCK_ATP PF01293.15 EDK37141.2 - 2.4e-216 718.7 0.0 2.8e-216 718.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 EDK37141.2 - 0.064 13.1 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EDK37141.2 - 0.12 11.9 0.8 0.3 10.6 0.6 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 EDK37141.2 - 0.15 11.4 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.1 EDK37141.2 - 0.27 9.6 0.2 0.47 8.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.11 EDK37142.2 - 1.1e-15 57.1 30.6 1.3e-15 56.9 20.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK37142.2 - 6e-10 38.8 9.6 6e-10 38.8 6.6 2.7 4 0 0 4 4 4 1 Ion channel regulatory protein UNC-93 Imm38 PF15599.1 EDK37142.2 - 0.0029 17.1 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 Immunity protein 38 Glyco_hydro_3 PF00933.16 EDK37143.2 - 1.2e-49 168.9 0.0 1.8e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain XPG_I PF00867.13 EDK37144.2 - 2.8e-26 91.4 0.0 8.3e-26 89.8 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 EDK37144.2 - 9.4e-05 22.0 0.0 0.00021 20.8 0.0 1.6 1 1 0 1 1 1 1 XPG domain containing XPG_N PF00752.12 EDK37144.2 - 0.0005 20.2 0.0 0.0015 18.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain PTPA PF03095.10 EDK37145.2 - 5.1e-111 370.6 0.0 6.2e-111 370.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein zf-RING_2 PF13639.1 EDK37146.2 - 2.1e-07 30.6 8.6 2.1e-07 30.6 6.0 2.2 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.3 EDK37146.2 - 1e-06 28.5 5.8 3.8e-06 26.7 4.0 2.0 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.2 EDK37146.2 - 4.1e-06 26.7 3.6 1.2e-05 25.3 2.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EDK37146.2 - 0.00011 21.9 2.0 0.00037 20.2 1.4 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 EDK37146.2 - 0.0033 17.0 9.6 0.0085 15.7 6.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 EDK37146.2 - 0.0075 16.2 8.0 0.022 14.7 5.5 1.9 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4_2 PF13923.1 EDK37146.2 - 0.012 15.6 9.4 0.04 13.9 6.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.17 EDK37146.2 - 0.94 9.2 10.1 0.86 9.3 4.4 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_3 PF13920.1 EDK37146.2 - 1 9.0 5.9 2.9 7.6 4.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 EDK37146.2 - 2.1 7.9 5.1 10 5.8 3.4 2.3 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.24 EDK37146.2 - 2.7 7.7 7.2 6.9 6.4 5.0 1.8 1 0 0 1 1 1 0 PHD-finger Herpes_Helicase PF02689.9 EDK37147.2 - 8.4e-07 27.1 0.0 1.2e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Helicase PIF1 PF05970.9 EDK37147.2 - 0.0027 16.6 0.2 0.0038 16.2 0.2 1.2 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.1 EDK37147.2 - 0.0041 17.2 0.0 0.013 15.5 0.0 1.9 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain DUF2158 PF09926.4 EDK37147.2 - 0.076 12.4 0.1 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) PIF1 PF05970.9 EDK37148.2 - 2.9e-46 158.0 1.4 3e-41 141.6 0.1 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 EDK37148.2 - 6.6e-18 64.9 0.0 9.9e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EDK37148.2 - 8.3e-06 25.9 0.0 1.9e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 EDK37148.2 - 0.00033 19.7 0.1 0.0013 17.8 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 EDK37148.2 - 0.0043 17.2 0.0 0.0088 16.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EDK37148.2 - 0.0086 15.8 0.1 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain Torsin PF06309.6 EDK37148.2 - 0.017 15.0 0.2 3.7 7.4 0.0 2.9 3 0 0 3 3 3 0 Torsin AAA_5 PF07728.9 EDK37148.2 - 0.029 14.1 0.1 0.068 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 EDK37148.2 - 0.1 12.7 0.0 0.41 10.8 0.0 2.1 1 1 0 1 1 1 0 RNA helicase FH2 PF02181.18 EDK37149.2 - 4.9e-79 265.8 6.1 1.5e-78 264.3 4.2 1.8 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_GBD PF06371.8 EDK37149.2 - 2.5e-15 56.3 5.5 2.5e-15 56.3 3.8 4.4 4 2 0 4 4 4 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 EDK37149.2 - 8.7e-11 41.5 0.4 8.7e-11 41.5 0.3 2.4 2 0 0 2 2 2 1 Diaphanous FH3 Domain Adaptin_binding PF10199.4 EDK37149.2 - 0.0047 17.2 8.9 0.047 13.9 6.2 2.9 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 FTHFS PF01268.14 EDK37150.2 - 4.2e-249 827.1 0.5 5.4e-249 826.8 0.4 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 EDK37150.2 - 3.4e-66 221.2 3.5 7.6e-66 220.1 1.0 2.5 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 EDK37150.2 - 3.3e-31 107.7 0.7 1.7e-30 105.4 0.5 2.2 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain NAD_binding_10 PF13460.1 EDK37151.2 - 3.5e-23 82.5 0.9 4.2e-23 82.3 0.7 1.1 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK37151.2 - 5.9e-09 35.7 0.1 6.9e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EDK37151.2 - 3.5e-07 29.7 4.1 1.4e-05 24.5 2.8 2.0 1 1 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 EDK37151.2 - 2.7e-05 23.0 1.1 5.3e-05 22.0 0.4 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 EDK37151.2 - 8e-05 21.7 0.2 0.00011 21.3 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 EDK37151.2 - 9.9e-05 22.6 0.1 0.0003 21.0 0.1 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EDK37151.2 - 0.00064 19.6 0.1 0.0013 18.6 0.1 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 EDK37151.2 - 0.0022 16.9 0.0 0.04 12.8 0.0 2.5 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 EDK37151.2 - 0.067 12.0 0.1 0.61 8.9 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain GPCR_chapero_1 PF11904.3 EDK37152.2 - 0.94 8.5 8.3 2.5 7.1 3.6 2.1 2 0 0 2 2 2 0 GPCR-chaperone DUF4557 PF15101.1 EDK37152.2 - 1.2 8.9 7.1 2.3 8.0 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Neur_chan_memb PF02932.11 EDK37152.2 - 6.6 6.5 6.3 13 5.5 4.4 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.4 EDK37153.2 - 2e-40 138.6 3.6 2e-40 138.6 2.5 2.5 3 0 0 3 3 3 1 Enhancer of polycomb-like SPATA24 PF15175.1 EDK37153.2 - 0.015 14.9 0.1 0.015 14.9 0.0 2.7 3 1 0 3 3 3 0 Spermatogenesis-associated protein 24 WD40 PF00400.27 EDK37154.2 - 3.9e-09 36.0 1.0 0.002 17.9 0.1 4.1 3 0 0 3 3 3 3 WD domain, G-beta repeat Herpes_ori_bp PF02399.10 EDK37154.2 - 0.073 11.0 0.7 0.11 10.4 0.0 1.5 2 0 0 2 2 2 0 Origin of replication binding protein Pkinase PF00069.20 EDK37155.2 - 6.5e-53 179.5 0.0 1.2e-52 178.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37155.2 - 8.4e-20 70.9 0.0 1.6e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK37155.2 - 0.09 12.5 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Aminotran_1_2 PF00155.16 EDK37156.1 - 3.7e-40 138.0 0.0 4.5e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EDK37156.1 - 0.00059 18.2 0.0 0.00086 17.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 EDK37156.1 - 0.0012 18.0 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Alliinase_C PF04864.8 EDK37156.1 - 0.0016 17.1 0.0 0.0027 16.4 0.0 1.3 1 0 0 1 1 1 1 Allinase NDT80_PhoG PF05224.7 EDK37157.2 - 3.5e-35 121.6 0.1 3.5e-35 121.6 0.1 2.0 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Nop14 PF04147.7 EDK37157.2 - 1.2 6.9 9.9 2.3 6.0 6.9 1.5 1 0 0 1 1 1 0 Nop14-like family Thiolase_N PF00108.18 EDK37158.1 - 2.3e-85 285.7 3.6 4.2e-85 284.9 2.5 1.4 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EDK37158.1 - 3.1e-47 159.0 0.3 5.5e-47 158.2 0.2 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EDK37158.1 - 1.5e-05 24.6 1.1 6.7e-05 22.4 0.2 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.5 EDK37158.1 - 0.1 12.6 0.0 0.32 11.0 0.0 2.0 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Gly-zipper_OmpA PF13436.1 EDK37159.2 - 0.16 11.6 0.2 0.64 9.6 0.0 1.8 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain ADH_N PF08240.7 EDK37163.2 - 1.2e-27 95.7 0.9 1.8e-27 95.2 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK37163.2 - 4.1e-18 65.1 0.0 6.8e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EDK37163.2 - 0.00022 20.8 0.0 0.00053 19.5 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated 2-Hacid_dh_C PF02826.14 EDK37163.2 - 0.0035 16.5 0.0 0.0071 15.5 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PAC2 PF09754.4 EDK37163.2 - 0.065 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 PAC2 family AlaDh_PNT_C PF01262.16 EDK37163.2 - 0.066 12.7 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.13 EDK37163.2 - 0.096 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Cyclin_N PF00134.18 EDK37166.2 - 6.2e-13 48.4 0.0 1e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain MFS_1 PF07690.11 EDK37167.2 - 3.3e-41 141.1 48.1 3.6e-41 141.0 31.2 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK37167.2 - 1.6e-13 49.7 26.0 2.3e-13 49.2 18.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EDK37167.2 - 1.2e-07 30.6 18.3 1.2e-07 30.6 12.7 2.8 1 1 0 3 3 3 1 Sugar (and other) transporter Tektin PF03148.9 EDK37167.2 - 0.21 10.1 0.0 0.28 9.6 0.0 1.1 1 0 0 1 1 1 0 Tektin family JAB PF01398.16 EDK37168.2 - 2.1e-11 43.5 0.0 4e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CRF1 PF10380.4 EDK37169.2 - 2.2e-28 99.0 6.1 2.2e-28 99.0 4.2 4.3 3 2 0 3 3 3 1 Transcription factor CRF1 PHD PF00628.24 EDK37170.2 - 2.2e-09 36.8 9.3 4.5e-09 35.8 6.4 1.6 1 0 0 1 1 1 1 PHD-finger TFIIS_M PF07500.9 EDK37170.2 - 2.6e-08 33.9 0.1 8.5e-08 32.2 0.0 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.8 EDK37170.2 - 2.8e-06 27.7 0.0 8.4e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 SPOC domain PHD_2 PF13831.1 EDK37170.2 - 0.0024 17.1 4.1 0.0024 17.1 2.9 1.8 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.17 EDK37170.2 - 0.92 9.2 7.0 0.17 11.6 1.1 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Tnp_zf-ribbon_2 PF13842.1 EDK37170.2 - 1.3 9.4 6.9 2 8.8 1.0 2.5 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon SDA1 PF05285.7 EDK37170.2 - 2.6 7.2 40.0 3.6 6.7 11.5 2.3 2 0 0 2 2 2 0 SDA1 Rad9_Rad53_bind PF08605.5 EDK37171.2 - 7.8e-27 93.6 0.0 1.8e-26 92.4 0.0 1.7 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.21 EDK37171.2 - 3.7e-11 42.9 0.6 1.5e-07 31.4 0.0 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PROL5-SMR PF15621.1 EDK37171.2 - 8.4 6.8 9.1 8.4 6.8 4.1 2.5 1 1 1 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family Pro_dh PF01619.13 EDK37172.1 - 2.4e-49 168.0 0.0 3.4e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase SLS PF14611.1 EDK37173.2 - 3.5e-33 114.8 0.0 5.9e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator DUF775 PF05603.7 EDK37173.2 - 0.001 18.6 1.0 0.084 12.3 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF775) CobW_C PF07683.9 EDK37173.2 - 0.086 12.5 0.0 5.8 6.7 0.0 2.5 2 0 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain ABC1 PF03109.11 EDK37174.2 - 1e-22 80.3 0.2 2.1e-22 79.3 0.2 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 EDK37174.2 - 0.032 13.9 0.1 0.12 12.0 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.27 EDK37175.2 - 4.1e-57 188.1 34.7 3e-09 36.4 0.0 12.4 12 1 0 12 12 12 8 WD domain, G-beta repeat Utp13 PF08625.6 EDK37175.2 - 2.8e-44 150.1 0.0 4.3e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Cytochrom_D1 PF02239.11 EDK37175.2 - 5.1e-06 25.0 0.7 0.071 11.3 0.1 3.6 3 0 0 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.3 EDK37175.2 - 0.00022 19.5 6.1 1.3 7.0 0.1 5.9 4 2 2 6 6 6 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 EDK37175.2 - 0.00083 19.1 0.2 21 4.9 0.0 5.9 5 3 1 6 6 6 0 Ciliary BBSome complex subunit 2, middle region Hira PF07569.6 EDK37175.2 - 0.017 14.3 0.1 1.4 8.1 0.0 4.0 5 1 1 6 6 6 0 TUP1-like enhancer of split eIF2A PF08662.6 EDK37175.2 - 0.021 14.5 0.6 4.2 7.0 0.0 4.1 3 2 1 5 5 5 0 Eukaryotic translation initiation factor eIF2A Acetyltransf_10 PF13673.1 EDK37175.2 - 0.18 11.9 0.8 29 4.8 0.0 3.9 5 1 0 5 5 5 0 Acetyltransferase (GNAT) domain Lectin_C PF00059.16 EDK37175.2 - 0.75 10.4 4.4 78 3.9 0.0 4.0 4 0 0 4 4 4 0 Lectin C-type domain Zn_clus PF00172.13 EDK37176.2 - 4e-07 29.8 18.5 7.8e-07 28.8 12.8 1.5 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.2 EDK37177.2 - 0.05 13.3 0.1 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 F-box-like CsoSCA PF08936.5 EDK37177.2 - 0.052 11.9 3.1 0.36 9.1 2.2 2.0 1 1 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase MSC PF09402.5 EDK37178.2 - 1.3e-106 356.1 0.2 2.2e-106 355.3 0.1 1.4 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain DUF2630 PF10944.3 EDK37178.2 - 0.00085 19.3 2.1 0.034 14.2 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2630) PBP1_TM PF14812.1 EDK37178.2 - 0.013 15.7 0.0 0.013 15.7 0.0 3.6 2 1 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FCH PF00611.18 EDK37178.2 - 0.042 14.0 0.3 0.042 14.0 0.2 2.3 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain RWD PF05773.17 EDK37179.2 - 1.4e-22 79.7 0.8 1.4e-22 79.7 0.5 1.7 2 1 0 2 2 2 1 RWD domain SH3_9 PF14604.1 EDK37180.2 - 4.3e-10 39.0 0.2 4.3e-10 39.0 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 EDK37180.2 - 7.1e-10 38.1 1.0 3e-09 36.1 0.0 2.3 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 EDK37180.2 - 4.2e-06 26.1 0.1 6.9e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF2309 PF10070.4 EDK37181.2 - 0.0003 19.0 0.5 0.00043 18.5 0.4 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2309) BUD22 PF09073.5 EDK37181.2 - 0.067 12.2 11.2 0.091 11.8 7.8 1.2 1 0 0 1 1 1 0 BUD22 DUF572 PF04502.8 EDK37181.2 - 0.96 8.5 8.1 1.7 7.8 5.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) ADH_zinc_N PF00107.21 EDK37183.1 - 1.2e-31 108.9 1.4 1.8e-31 108.4 1.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK37183.1 - 6.6e-29 99.8 0.1 1.3e-28 98.9 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EDK37183.1 - 0.00014 22.7 0.3 0.00036 21.4 0.1 1.8 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Transketolase_N PF00456.16 EDK37184.1 - 2.7e-149 496.4 0.0 4.4e-149 495.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 EDK37184.1 - 1.3e-43 148.5 0.0 1.9e-43 148.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EDK37184.1 - 9.6e-12 44.9 0.0 2.4e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 EDK37184.1 - 5.2e-05 22.3 0.0 0.00041 19.3 0.0 2.0 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 EDK37184.1 - 0.0063 16.1 0.2 0.061 12.8 0.1 2.3 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Opy2 PF09463.5 EDK37185.2 - 0.00017 21.6 18.2 0.00026 20.9 12.6 1.3 1 0 0 1 1 1 1 Opy2 protein FAM220 PF15487.1 EDK37185.2 - 0.022 14.1 1.0 0.036 13.4 0.7 1.3 1 0 0 1 1 1 0 FAM220 family ASFV_J13L PF05568.6 EDK37185.2 - 0.025 14.1 0.2 0.11 12.0 0.2 1.9 1 1 0 1 1 1 0 African swine fever virus J13L protein SKG6 PF08693.5 EDK37185.2 - 0.075 12.3 0.4 0.15 11.3 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-Apc11 PF12861.2 EDK37185.2 - 0.08 12.7 4.9 0.15 11.8 3.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Not3 PF04065.10 EDK37186.2 - 6.3e-87 290.7 29.1 9.8e-87 290.0 20.2 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 EDK37186.2 - 3.7e-33 114.2 4.9 3.7e-33 114.2 3.4 2.2 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Mnd1 PF03962.10 EDK37186.2 - 0.005 16.5 9.4 0.005 16.5 6.5 2.7 2 1 1 3 3 3 2 Mnd1 family Ish1 PF10281.4 EDK37186.2 - 0.049 13.7 0.4 0.049 13.7 0.3 2.2 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein bZIP_1 PF00170.16 EDK37186.2 - 1.5 8.8 14.3 2.5 8.1 0.1 4.1 4 0 0 4 4 4 0 bZIP transcription factor Enkurin PF13864.1 EDK37186.2 - 2.8 8.2 14.9 0.59 10.3 4.4 3.1 2 0 0 2 2 2 0 Calmodulin-binding LMWPc PF01451.16 EDK37187.1 - 8e-35 120.1 0.0 9.3e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Med15_fungi PF05397.7 EDK37188.2 - 1.2e-43 147.6 3.4 1.2e-43 147.6 2.3 3.4 3 0 0 3 3 3 1 Mediator complex subunit 15 WD40 PF00400.27 EDK37189.2 - 6e-67 219.3 30.6 8.8e-09 34.9 1.0 12.5 12 1 0 12 12 12 11 WD domain, G-beta repeat Utp12 PF04003.7 EDK37189.2 - 4.2e-23 81.3 0.4 7.1e-23 80.6 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 EDK37189.2 - 2e-08 32.8 1.2 0.078 11.1 0.0 4.4 5 0 0 5 5 5 3 Nucleoporin Nup120/160 Hira PF07569.6 EDK37189.2 - 0.0016 17.7 2.6 2.7 7.1 0.0 4.7 4 1 1 5 5 5 2 TUP1-like enhancer of split PLA2_B PF01735.13 EDK37190.2 - 3.6e-198 658.7 3.4 4.3e-198 658.4 2.4 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain His_Phos_1 PF00300.17 EDK37191.2 - 3.9e-15 56.2 0.4 6.1e-15 55.6 0.0 1.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Exo_endo_phos PF03372.18 EDK37192.2 - 4.7e-21 75.8 0.1 6.9e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 EDK37192.2 - 1.1e-15 56.8 14.9 3.3e-11 42.5 1.8 2.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK37192.2 - 7.3e-14 51.2 11.0 1.6e-10 40.6 1.5 3.0 1 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 EDK37192.2 - 9.1e-10 37.2 12.9 0.016 15.1 0.0 5.6 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 EDK37192.2 - 1.6e-05 24.3 10.0 0.53 10.7 0.0 5.0 5 0 0 5 5 5 3 Leucine rich repeat LRR_6 PF13516.1 EDK37192.2 - 0.00069 19.4 3.3 0.36 11.0 0.0 4.0 3 0 0 3 3 3 1 Leucine Rich repeat Exo_endo_phos_2 PF14529.1 EDK37192.2 - 0.07 12.7 0.0 0.22 11.1 0.0 1.9 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase HhH-GPD PF00730.20 EDK37193.2 - 1.2e-18 67.3 0.0 3.4e-18 65.9 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EDK37193.2 - 1.9e-05 24.0 0.0 7.8e-05 22.1 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif NESP55 PF06390.7 EDK37193.2 - 9.6 5.5 10.2 28 3.9 7.2 1.6 1 1 1 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) Fungal_trans PF04082.13 EDK37194.2 - 1.8e-30 105.7 0.8 3.4e-30 104.7 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37194.2 - 5.2e-11 42.2 11.6 1.1e-10 41.1 8.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_11 PF08241.7 EDK37195.1 - 1.3e-15 57.6 0.0 3.1e-15 56.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK37195.1 - 3e-14 53.2 0.0 6e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK37195.1 - 1.7e-12 47.2 0.0 2.5e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK37195.1 - 1.4e-10 41.1 0.0 2.2e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK37195.1 - 8.6e-10 39.1 0.0 1.6e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK37195.1 - 6.9e-08 32.7 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK37195.1 - 2.6e-07 30.0 0.0 5e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EDK37195.1 - 8.4e-07 29.0 0.0 1.9e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK37195.1 - 0.00068 19.0 0.0 0.0032 16.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 EDK37195.1 - 0.04 12.9 0.0 0.1 11.6 0.0 1.7 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase PIG-L PF02585.12 EDK37196.2 - 1.2e-23 84.0 0.0 1.6e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Actin PF00022.14 EDK37197.2 - 4e-69 232.9 0.0 4.8e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Actin LDB19 PF13002.2 EDK37198.2 - 1.8e-62 210.2 0.5 3.1e-62 209.4 0.4 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 EDK37198.2 - 8e-06 25.7 2.2 2.4e-05 24.1 0.0 2.8 4 1 0 4 4 4 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.20 EDK37199.2 - 1.6e-60 204.4 0.0 3.3e-60 203.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37199.2 - 2.9e-20 72.4 0.0 4.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.1 EDK37199.2 - 3.1e-07 30.7 0.0 0.01 16.2 0.0 3.4 3 0 0 3 3 3 2 PAS domain PAS PF00989.19 EDK37199.2 - 2.7e-05 23.9 0.0 0.5 10.1 0.0 3.1 3 0 0 3 3 3 2 PAS fold Kinase-like PF14531.1 EDK37199.2 - 0.0004 19.4 0.0 0.00082 18.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK37199.2 - 0.0017 18.1 0.0 0.0054 16.4 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EDK37199.2 - 0.017 14.2 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Thiolase_N PF00108.18 EDK37200.2 - 2e-85 285.9 1.2 2.9e-85 285.4 0.8 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EDK37200.2 - 7.6e-45 151.3 0.6 1.5e-44 150.3 0.4 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EDK37200.2 - 0.0034 16.8 0.1 0.008 15.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EDK37200.2 - 0.094 12.3 0.1 0.63 9.7 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SLD3 PF08639.5 EDK37201.2 - 7.3e-95 318.4 13.0 7.3e-95 318.4 9.0 1.5 2 0 0 2 2 2 1 DNA replication regulator SLD3 DUF1546 PF07571.8 EDK37202.2 - 1.2e-31 108.6 0.1 2.4e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 EDK37202.2 - 1e-27 95.8 0.0 3.6e-27 94.1 0.0 2.0 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 EDK37202.2 - 2e-06 27.8 0.2 5.5e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK37202.2 - 0.00016 21.6 0.3 0.00016 21.6 0.2 2.2 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 EDK37202.2 - 0.023 14.4 0.0 0.071 12.8 0.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit HEAT_EZ PF13513.1 EDK37202.2 - 0.032 14.7 0.1 10 6.7 0.0 3.7 3 1 0 3 3 3 0 HEAT-like repeat XPG_N PF00752.12 EDK37202.2 - 0.11 12.7 0.1 0.54 10.5 0.0 2.2 3 0 0 3 3 3 0 XPG N-terminal domain SlyX PF04102.7 EDK37203.2 - 0.088 13.1 0.1 0.088 13.1 0.1 2.9 3 0 0 3 3 3 0 SlyX PhoU PF01895.14 EDK37203.2 - 0.19 12.1 0.4 0.19 12.1 0.3 2.3 3 0 0 3 3 3 0 PhoU domain DUF1212 PF06738.7 EDK37204.2 - 0.056 12.9 1.2 0.077 12.4 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1212) AA_permease PF00324.16 EDK37206.2 - 6.5e-51 173.1 45.8 8.3e-51 172.7 31.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK37206.2 - 1e-11 44.0 51.4 1.5e-11 43.4 35.6 1.2 1 0 0 1 1 1 1 Amino acid permease DEAD PF00270.24 EDK37207.2 - 1.8e-44 151.2 0.0 8.1e-44 149.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK37207.2 - 2.6e-23 81.6 0.2 8.2e-23 80.0 0.2 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.1 EDK37207.2 - 0.00032 20.3 0.0 0.28 10.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain SNF2_N PF00176.18 EDK37207.2 - 0.011 14.5 0.0 0.032 13.0 0.0 1.7 2 0 0 2 2 2 0 SNF2 family N-terminal domain ECH PF00378.15 EDK37208.2 - 6.4e-29 100.7 0.0 9e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ATP13 PF12921.2 EDK37209.2 - 1.7e-37 127.5 0.3 1.7e-37 127.5 0.2 1.9 2 0 0 2 2 2 1 Mitochondrial ATPase expression CppA_C PF14507.1 EDK37209.2 - 0.058 13.5 0.1 0.22 11.7 0.1 2.1 1 0 0 1 1 1 0 CppA C-terminal Nop52 PF05997.7 EDK37210.2 - 1.1e-76 257.0 1.5 1.4e-76 256.7 1.0 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 ATP11 PF06644.6 EDK37210.2 - 0.036 13.5 0.3 0.036 13.5 0.2 2.0 2 0 0 2 2 2 0 ATP11 protein Nucleoplasmin PF03066.10 EDK37210.2 - 1.7 8.1 12.9 0.12 11.8 0.8 2.2 2 0 0 2 2 2 0 Nucleoplasmin Slu7 PF11708.3 EDK37211.2 - 1.3e-50 172.4 6.6 1.9e-50 171.8 4.6 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor BTK PF00779.14 EDK37211.2 - 4.8e-05 22.8 5.5 0.00011 21.7 3.8 1.6 1 0 0 1 1 1 1 BTK motif DUF3315 PF11776.3 EDK37211.2 - 2.4 7.7 5.4 2.6 7.6 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3315) HLH PF00010.21 EDK37212.2 - 1.3e-10 40.7 0.3 1.3e-10 40.7 0.2 2.3 3 1 0 3 3 3 1 Helix-loop-helix DNA-binding domain Atg14 PF10186.4 EDK37212.2 - 0.047 12.6 0.8 0.089 11.7 0.6 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HIM1 PF08732.5 EDK37212.2 - 0.096 11.1 0.1 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 HIM1 Cullin_binding PF03556.10 EDK37213.2 - 1.4e-33 115.5 5.1 2.1e-33 114.9 3.5 1.3 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.1 EDK37213.2 - 1.5e-14 53.1 0.0 3.6e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain Cullin PF00888.17 EDK37214.2 - 5.3e-29 101.2 0.7 2.1e-28 99.2 0.0 2.1 3 0 0 3 3 3 1 Cullin family HTH_27 PF13463.1 EDK37214.2 - 4.1e-05 23.8 0.0 0.029 14.6 0.0 2.9 2 0 0 2 2 2 2 Winged helix DNA-binding domain PHB_acc PF05233.8 EDK37214.2 - 0.071 12.8 0.0 10 5.9 0.0 2.5 2 0 0 2 2 2 0 PHB accumulation regulatory domain TFIID_20kDa PF03847.8 EDK37215.2 - 7.3e-30 103.0 0.2 1.7e-29 101.9 0.1 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.18 EDK37215.2 - 0.015 15.3 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2052 PF09747.4 EDK37215.2 - 1.1 9.1 7.4 1.8 8.4 5.1 1.4 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CorA PF01544.13 EDK37215.2 - 2.4 7.0 4.3 4 6.3 0.0 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Allexi_40kDa PF05549.6 EDK37215.2 - 2.6 7.2 6.3 13 4.9 2.7 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein OPT PF03169.10 EDK37216.2 - 4.9e-129 431.5 42.0 5.9e-129 431.3 29.1 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4231 PF14015.1 EDK37216.2 - 0.079 12.9 1.1 0.48 10.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) OB_NTP_bind PF07717.11 EDK37217.2 - 1.5e-16 60.2 0.0 5.6e-16 58.3 0.0 2.1 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EDK37217.2 - 4e-15 55.6 1.8 5.4e-15 55.2 0.0 2.1 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EDK37217.2 - 3.6e-13 49.1 0.0 1.4e-12 47.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK37217.2 - 5.8e-08 32.4 0.0 8.4e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase RWD PF05773.17 EDK37217.2 - 1.3e-07 31.5 0.2 4.1e-07 29.8 0.1 2.0 1 0 0 1 1 1 1 RWD domain T2SE PF00437.15 EDK37217.2 - 4e-07 29.2 0.1 7.2e-07 28.3 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 EDK37217.2 - 2.9e-05 23.9 1.4 5e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.11 EDK37217.2 - 0.00023 20.4 0.0 0.00097 18.4 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_29 PF13555.1 EDK37217.2 - 0.00027 20.4 0.0 0.00059 19.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 EDK37217.2 - 0.0013 18.1 0.0 0.0036 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK37217.2 - 0.0031 17.2 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain KaiC PF06745.8 EDK37217.2 - 0.0032 16.6 0.0 0.0093 15.1 0.0 1.7 1 0 0 1 1 1 1 KaiC Zot PF05707.7 EDK37217.2 - 0.0058 16.1 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_22 PF13401.1 EDK37217.2 - 0.0062 16.6 0.8 0.024 14.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EDK37217.2 - 0.011 16.0 0.3 0.011 16.0 0.2 4.7 3 1 1 4 4 4 0 AAA domain Sigma54_activat PF00158.21 EDK37217.2 - 0.033 13.6 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.22 EDK37217.2 - 0.055 13.7 0.3 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Zn_clus PF00172.13 EDK37218.2 - 3.2e-09 36.5 14.6 6e-09 35.6 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.4 EDK37218.2 - 3.5 5.7 7.6 7.3 4.7 5.2 1.4 1 0 0 1 1 1 0 Transmembrane protein Gp_dh_C PF02800.15 EDK37219.1 - 4.5e-72 240.6 0.0 6.9e-72 240.0 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 EDK37219.1 - 1.6e-60 203.4 0.3 2.3e-60 202.9 0.2 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 EDK37219.1 - 0.0034 16.5 0.2 0.0075 15.4 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF2436 PF10365.4 EDK37219.1 - 0.012 15.2 0.6 0.022 14.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) DapB_N PF01113.15 EDK37219.1 - 0.024 14.5 0.4 0.071 13.0 0.2 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.21 EDK37219.1 - 0.094 12.2 0.1 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase CENP-L PF13092.1 EDK37220.2 - 0.00011 21.9 0.3 0.00054 19.7 0.1 2.2 1 1 1 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 PMT PF02366.13 EDK37221.2 - 1.1e-91 306.6 19.9 1.3e-91 306.3 13.8 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EDK37221.2 - 1.7e-24 86.4 0.0 2.5e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.1 EDK37221.2 - 2.7e-09 37.1 13.1 2.7e-09 37.1 9.1 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF4491 PF14898.1 EDK37221.2 - 7.4 6.7 8.9 2.4 8.3 3.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4491) Fe-S_biosyn PF01521.15 EDK37222.2 - 6.7e-11 42.1 0.2 1.1e-10 41.4 0.1 1.4 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DGF-1_4 PF11024.3 EDK37222.2 - 0.14 12.5 0.1 0.21 12.0 0.1 1.3 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 HEAT PF02985.17 EDK37223.2 - 3e-41 135.7 22.3 4.4e-05 23.2 0.0 11.7 12 0 0 12 12 11 9 HEAT repeat HEAT_2 PF13646.1 EDK37223.2 - 1.1e-34 118.5 14.9 1.4e-07 31.7 0.3 8.0 3 3 6 9 9 9 9 HEAT repeats HEAT_EZ PF13513.1 EDK37223.2 - 6.3e-14 51.9 6.8 0.053 14.0 0.0 8.2 8 0 0 8 8 8 4 HEAT-like repeat Adaptin_N PF01602.15 EDK37223.2 - 2.6e-13 49.1 0.0 1e-05 24.0 0.0 3.0 1 1 2 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 EDK37223.2 - 5.2e-12 45.9 0.5 0.017 15.5 0.0 6.8 5 3 4 9 9 8 2 Vacuolar 14 Fab1-binding region Arm PF00514.18 EDK37223.2 - 1.1e-06 28.2 0.6 10 6.1 0.0 6.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.2 EDK37223.2 - 3.3e-06 27.0 0.3 0.39 10.5 0.0 4.4 2 2 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 DUF2435 PF10363.4 EDK37223.2 - 1.9e-05 24.4 4.7 0.11 12.4 0.0 4.7 5 0 0 5 5 5 2 Protein of unknown function (DUF2435) CLASP_N PF12348.3 EDK37223.2 - 0.00036 19.9 0.1 0.74 9.1 0.0 4.6 5 1 0 5 5 5 1 CLASP N terminal Ecm29 PF13001.2 EDK37223.2 - 0.0016 17.0 1.0 1.8 6.9 0.1 3.0 2 1 1 3 3 3 2 Proteasome stabiliser Trp_Tyr_perm PF03222.8 EDK37223.2 - 0.004 16.0 0.1 0.0069 15.2 0.0 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family API5 PF05918.6 EDK37223.2 - 0.095 11.1 0.0 0.76 8.1 0.0 2.5 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Cohesin_HEAT PF12765.2 EDK37223.2 - 0.2 11.6 5.0 1.3 9.0 0.0 4.4 6 0 0 6 6 6 0 HEAT repeat associated with sister chromatid cohesion M11L PF11099.3 EDK37223.2 - 0.3 10.8 2.8 65 3.2 0.0 4.3 3 2 2 6 6 6 0 Apoptosis regulator M11L like His_Phos_1 PF00300.17 EDK37224.2 - 3.3e-18 66.2 0.0 4.8e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Guanylate_cyc_2 PF09778.4 EDK37224.2 - 0.0042 16.3 0.0 0.36 9.9 0.0 2.1 2 0 0 2 2 2 2 Guanylylate cyclase SPX PF03105.14 EDK37226.2 - 3.8e-10 40.0 2.3 2.8e-06 27.3 0.0 3.6 2 2 1 4 4 4 2 SPX domain DUF1902 PF08972.6 EDK37226.2 - 0.083 12.4 0.1 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) NIR_SIR PF01077.17 EDK37227.2 - 1.6e-50 170.5 0.0 9e-46 155.0 0.0 2.3 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 EDK37227.2 - 1.2e-29 101.7 0.1 7.3e-15 54.3 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 EDK37227.2 - 1.5e-26 93.1 0.1 5.8e-26 91.1 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin POR_N PF01855.14 EDK37227.2 - 0.0017 17.8 0.0 0.017 14.6 0.0 2.2 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Flavodoxin_3 PF12641.2 EDK37227.2 - 0.065 12.6 0.6 1.6 8.1 0.0 2.9 3 0 0 3 3 3 0 Flavodoxin domain Nbl1_Borealin_N PF10444.4 EDK37228.2 - 0.0009 18.5 1.7 0.0013 18.0 1.2 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.1 EDK37229.2 - 8.3e-11 42.2 0.0 1.1e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 EDK37229.2 - 3.7e-06 26.6 0.0 4.9e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like Ku_N PF03731.10 EDK37229.2 - 0.00014 21.3 0.1 0.006 16.0 0.1 2.3 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain UIM PF02809.15 EDK37229.2 - 0.0011 18.3 0.8 0.0029 17.0 0.6 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif VWA PF00092.23 EDK37229.2 - 0.0013 18.5 1.2 0.0019 17.9 0.8 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain PDH PF02153.12 EDK37229.2 - 0.033 13.0 0.0 0.05 12.4 0.0 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase GAF PF01590.21 EDK37230.2 - 0.0011 19.0 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 GAF domain Swi3 PF07962.7 EDK37231.2 - 1.8e-19 69.1 0.1 3.1e-19 68.3 0.1 1.5 1 1 0 1 1 1 1 Replication Fork Protection Component Swi3 DUF3896 PF13035.1 EDK37231.2 - 0.11 12.5 0.4 0.25 11.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) TB2_DP1_HVA22 PF03134.14 EDK37232.2 - 0.029 14.1 1.9 0.053 13.2 1.3 1.5 1 0 0 1 1 1 0 TB2/DP1, HVA22 family HECT_2 PF09814.4 EDK37233.2 - 3.1e-84 282.7 0.2 3.8e-84 282.4 0.2 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DHHA2 PF02833.9 EDK37234.2 - 2.8e-32 111.5 0.2 5.5e-32 110.6 0.1 1.5 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 EDK37234.2 - 2.6e-11 43.3 0.2 4.5e-11 42.5 0.2 1.5 1 0 0 1 1 1 1 DHH family PMT PF02366.13 EDK37235.2 - 3e-76 256.0 22.1 3e-76 256.0 15.3 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EDK37235.2 - 6.2e-17 61.7 2.3 5.6e-16 58.6 1.2 2.1 1 1 1 2 2 2 1 MIR domain Herpes_US9 PF06072.6 EDK37235.2 - 0.037 13.8 0.1 21 5.0 0.0 3.6 3 0 0 3 3 3 0 Alphaherpesvirus tegument protein US9 Hamartin PF04388.7 EDK37236.2 - 8.4e-09 34.6 6.7 1.6e-08 33.7 4.6 1.6 1 1 0 1 1 1 1 Hamartin protein SlyX PF04102.7 EDK37236.2 - 0.4 11.0 9.8 1.1 9.7 0.0 4.2 3 1 1 4 4 4 0 SlyX DUF4600 PF15372.1 EDK37236.2 - 6.4 6.9 14.5 1.7 8.8 3.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) NUDIX PF00293.23 EDK37237.2 - 2.4e-05 23.9 0.0 4.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain PQ-loop PF04193.9 EDK37240.2 - 8.4e-24 82.9 6.5 4.3e-20 71.0 0.1 2.7 2 0 0 2 2 2 2 PQ loop repeat DUF872 PF05915.7 EDK37240.2 - 0.14 11.9 2.0 0.13 12.0 0.2 1.8 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Rad4 PF03835.10 EDK37241.2 - 2.4e-31 108.0 3.0 6.9e-31 106.6 2.1 1.8 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 EDK37241.2 - 4.9e-20 71.0 0.0 1e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 EDK37241.2 - 8.6e-20 70.0 0.1 2e-19 68.8 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EDK37241.2 - 1.5e-11 44.4 0.7 1.1e-10 41.6 0.0 2.9 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 EDK37241.2 - 0.0057 16.8 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily GRP PF07172.6 EDK37241.2 - 1.3 9.5 8.3 3.6 8.1 5.8 1.7 1 0 0 1 1 1 0 Glycine rich protein family H_kinase_N PF12282.3 EDK37242.2 - 0.044 13.3 0.1 0.095 12.3 0.1 1.5 1 0 0 1 1 1 0 Signal transduction histidine kinase Lyase_1 PF00206.15 EDK37243.2 - 4.8e-117 390.5 0.0 6.2e-117 390.2 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 EDK37243.2 - 7.4e-25 86.7 0.0 1.6e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus Serine_rich PF08824.5 EDK37243.2 - 0.094 12.4 0.0 7.4 6.2 0.0 2.7 2 1 0 2 2 2 0 Serine rich protein interaction domain ADH_N PF08240.7 EDK37243.2 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain DUF3385 PF11865.3 EDK37243.2 - 0.16 11.8 0.1 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) SPT2 PF08243.6 EDK37244.2 - 1.9e-27 95.8 21.5 1.9e-27 95.8 14.9 2.4 2 0 0 2 2 2 1 SPT2 chromatin protein Init_tRNA_PT PF04179.7 EDK37245.2 - 2.8e-146 487.9 0.3 3.1e-146 487.7 0.2 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase FSH1 PF03959.8 EDK37246.2 - 6.2e-52 176.1 0.0 7.2e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 EDK37246.2 - 3.1e-08 33.5 0.0 4.1e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK37246.2 - 7e-08 32.6 0.0 3.6e-07 30.2 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK37246.2 - 0.00012 21.7 0.0 0.25 10.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 EDK37246.2 - 0.0048 16.5 0.0 0.015 14.8 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase BAAT_C PF08840.6 EDK37246.2 - 0.016 14.8 0.0 0.025 14.2 0.0 1.4 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 EDK37246.2 - 0.02 14.3 0.6 0.71 9.2 0.2 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 EDK37246.2 - 0.13 11.4 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Pox_MCEL PF03291.11 EDK37247.2 - 8.3e-93 310.8 0.0 1.2e-92 310.2 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_18 PF12847.2 EDK37247.2 - 2.5e-06 28.0 0.0 6.4e-06 26.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK37247.2 - 1.1e-05 25.8 0.0 4.2e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK37247.2 - 1.1e-05 25.0 0.0 3.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK37247.2 - 9.8e-05 22.6 0.0 0.00028 21.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK37247.2 - 0.00024 21.5 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Vel1p PF10339.4 EDK37247.2 - 0.0004 19.5 0.0 0.00082 18.5 0.0 1.4 1 0 0 1 1 1 1 Yeast-specific zinc responsive Methyltransf_26 PF13659.1 EDK37247.2 - 0.0031 17.5 0.0 0.008 16.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EDK37247.2 - 0.12 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family zf-C2H2_2 PF12756.2 EDK37248.2 - 0.087 12.9 0.2 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 EDK37248.2 - 0.095 13.0 1.3 0.22 11.9 0.9 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.2 EDK37248.2 - 0.11 12.7 1.9 0.27 11.4 1.4 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 EDK37248.2 - 0.11 12.8 0.8 0.29 11.5 0.5 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger TMF_TATA_bd PF12325.3 EDK37250.2 - 1.4e-33 115.2 15.3 1.4e-33 115.2 10.6 6.0 3 2 3 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 EDK37250.2 - 5.8e-15 54.8 12.3 5.8e-15 54.8 8.5 8.6 6 3 1 8 8 8 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.6 EDK37250.2 - 0.00023 21.0 4.4 0.00023 21.0 3.1 6.5 2 1 1 5 5 5 1 Autophagy protein 16 (ATG16) HALZ PF02183.13 EDK37250.2 - 0.0023 17.6 1.8 0.0023 17.6 1.2 7.4 7 1 0 8 8 8 2 Homeobox associated leucine zipper Reo_sigmaC PF04582.7 EDK37250.2 - 2 7.4 27.0 0.29 10.2 3.6 4.1 2 1 2 4 4 4 0 Reovirus sigma C capsid protein Vac_Fusion PF02346.11 EDK37250.2 - 2.9 7.3 11.2 0.33 10.4 0.4 4.2 4 0 0 4 4 4 0 Chordopoxvirus fusion protein Utp12 PF04003.7 EDK37251.2 - 8.2e-07 28.9 0.1 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF2677 PF10838.3 EDK37251.2 - 0.018 14.6 0.0 1.8 8.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2677) Pribosyltran PF00156.22 EDK37253.1 - 1.5e-09 37.6 0.2 1e-08 34.9 0.1 2.1 1 1 0 1 1 1 1 Phosphoribosyl transferase domain IBN_N PF03810.14 EDK37254.2 - 1.4e-14 53.7 0.0 1.9e-13 50.1 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.5 EDK37254.2 - 9e-08 31.0 0.0 8.8e-07 27.8 0.0 2.4 1 1 0 1 1 1 1 Cse1 Xpo1 PF08389.7 EDK37254.2 - 0.066 13.1 1.3 0.38 10.6 0.0 3.0 3 0 0 3 3 3 0 Exportin 1-like protein DUF3533 PF12051.3 EDK37255.1 - 1.4e-18 66.8 0.0 2.1e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF3533 PF12051.3 EDK37256.2 - 2e-83 280.2 22.5 2.3e-83 280.0 15.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) SurE PF01975.12 EDK37257.2 - 6e-06 25.6 0.0 1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE YihI PF04220.7 EDK37257.2 - 1.1 8.5 7.2 0.5 9.6 1.2 2.6 1 1 1 2 2 2 0 Der GTPase activator (YihI) AA_permease_2 PF13520.1 EDK37258.2 - 8e-59 199.2 36.7 1e-58 198.9 25.5 1.1 1 0 0 1 1 1 1 Amino acid permease DDHD PF02862.12 EDK37259.2 - 0.98 9.1 6.6 1.6 8.4 4.6 1.3 1 0 0 1 1 1 0 DDHD domain Rad1 PF02144.11 EDK37260.2 - 2.1e-77 259.5 0.1 2.7e-77 259.2 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 vATP-synt_AC39 PF01992.11 EDK37261.2 - 2.1e-84 283.5 0.0 2.4e-84 283.3 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Dor1 PF04124.7 EDK37262.2 - 3.9e-18 65.0 15.1 2.6e-15 55.7 6.2 2.3 2 1 0 2 2 2 2 Dor1-like family RNA_pol_Rpb1_6 PF04992.9 EDK37262.2 - 0.0012 18.6 2.8 0.0028 17.4 1.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 SNF2_N PF00176.18 EDK37263.2 - 3.2e-65 219.8 0.4 1.4e-64 217.8 0.0 2.2 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK37263.2 - 3.8e-15 55.5 0.0 2e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 EDK37263.2 - 2e-07 30.9 6.4 4.1e-07 29.9 4.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK37263.2 - 2.4e-06 27.1 4.0 4.5e-06 26.2 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK37263.2 - 0.00014 21.5 6.5 0.00034 20.3 4.4 1.8 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EDK37263.2 - 0.0005 19.7 6.0 0.001 18.7 4.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.24 EDK37263.2 - 0.00097 18.6 0.0 0.0034 16.8 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.20 EDK37263.2 - 0.0014 18.2 4.6 0.0065 16.1 3.3 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EDK37263.2 - 0.0077 15.9 2.6 0.023 14.4 1.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK37263.2 - 0.28 11.0 5.3 0.77 9.6 3.7 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE PF01363.16 EDK37263.2 - 0.83 9.5 4.0 2 8.3 2.7 1.6 1 0 0 1 1 1 0 FYVE zinc finger Prok-RING_4 PF14447.1 EDK37263.2 - 0.89 9.1 4.5 3 7.4 0.9 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.1 EDK37263.2 - 1.5 8.4 4.5 3.4 7.3 3.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TPR_11 PF13414.1 EDK37264.1 - 3.8e-09 36.0 0.3 0.00033 20.2 0.1 2.4 2 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EDK37264.1 - 1.4e-06 27.6 2.9 4.6e-05 22.8 0.2 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK37264.1 - 5.1e-06 26.0 4.8 0.00033 20.3 0.2 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 EDK37264.1 - 3.2e-05 23.7 0.1 0.00011 21.9 0.0 1.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37264.1 - 0.049 14.3 2.8 7.8 7.3 0.6 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 EDK37264.1 - 0.05 13.3 0.2 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Strep_SA_rep PF06696.6 EDK37264.1 - 0.075 12.8 0.2 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Streptococcal surface antigen repeat TPR_14 PF13428.1 EDK37264.1 - 0.08 13.6 0.5 0.48 11.2 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat rve_3 PF13683.1 EDK37264.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain TPR_6 PF13174.1 EDK37264.1 - 1.5 9.4 3.7 4.7 7.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.16 EDK37266.1 - 9.4e-62 209.0 0.0 1.1e-61 208.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 EDK37266.1 - 0.0066 14.7 0.0 0.011 14.0 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme HHH PF00633.18 EDK37266.1 - 0.14 11.8 0.0 0.38 10.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_S17 PF00366.15 EDK37267.1 - 1.9e-11 43.8 3.4 4.2e-11 42.7 2.4 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 HlyD_2 PF12700.2 EDK37267.1 - 0.93 8.5 10.0 0.041 13.0 3.2 1.5 2 0 0 2 2 2 0 HlyD family secretion protein RNA_pol_Rpb1_5 PF04998.12 EDK37267.1 - 7.8 5.6 7.7 12 5.0 5.3 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Ion_trans_2 PF07885.11 EDK37268.2 - 1.1e-27 95.5 38.5 3e-18 65.2 4.4 3.5 3 1 0 3 3 3 2 Ion channel Nucleoside_tran PF01733.13 EDK37269.2 - 3.5e-51 174.2 4.7 6.7e-51 173.2 3.2 1.5 1 0 0 1 1 1 1 Nucleoside transporter Diphthamide_syn PF01866.12 EDK37271.2 - 1.3e-40 139.5 0.0 1.5e-38 132.8 0.0 2.8 2 1 0 2 2 2 2 Putative diphthamide synthesis protein SPC25 PF06703.6 EDK37272.1 - 1.3e-30 106.1 1.9 1.4e-30 105.9 1.3 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) YSIRK_signal PF04650.12 EDK37272.1 - 0.12 11.9 1.0 0.29 10.7 0.7 1.6 1 0 0 1 1 1 0 YSIRK type signal peptide zf-C3HC4_2 PF13923.1 EDK37273.2 - 1.4e-07 31.4 4.3 2.7e-07 30.5 3.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK37273.2 - 3.2e-07 29.9 2.6 9.8e-07 28.4 1.9 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EDK37273.2 - 1e-06 28.2 3.4 2.1e-06 27.3 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK37273.2 - 1.9e-06 27.5 4.4 3.4e-06 26.7 3.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EDK37273.2 - 5.6e-06 25.9 3.8 9.9e-06 25.1 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EDK37273.2 - 3.6e-05 23.3 1.6 6.8e-05 22.5 0.7 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK37273.2 - 0.00024 20.8 4.6 0.0025 17.6 3.6 2.2 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-MIZ PF02891.15 EDK37273.2 - 5.4 6.6 6.6 21 4.7 4.6 2.0 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.1 EDK37273.2 - 5.7 6.5 8.1 1.5e+02 2.0 0.0 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 TFR_dimer PF04253.10 EDK37274.2 - 1.5e-17 63.3 1.1 3.4e-17 62.1 0.8 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.17 EDK37274.2 - 3.6e-07 29.7 0.0 0.0003 20.4 0.0 2.4 2 0 0 2 2 2 2 PA domain Peptidase_M28 PF04389.12 EDK37274.2 - 0.00066 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 EntA_Immun PF08951.5 EDK37274.2 - 0.025 14.7 0.1 0.27 11.3 0.1 2.6 1 1 1 2 2 2 0 Enterocin A Immunity ChaC PF04752.7 EDK37275.2 - 9.7e-51 172.2 0.0 1.8e-50 171.3 0.0 1.4 1 1 0 1 1 1 1 ChaC-like protein Nha1_C PF08619.5 EDK37276.2 - 1.1e-102 344.6 37.8 1.4e-102 344.2 26.2 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 EDK37276.2 - 8.7e-57 192.3 20.3 1e-56 192.1 14.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FlgD_ig PF13860.1 EDK37276.2 - 0.0077 15.9 0.3 0.19 11.4 0.0 2.4 2 0 0 2 2 2 1 FlgD Ig-like domain Aminotran_3 PF00202.16 EDK37277.1 - 8e-105 350.4 0.0 9.9e-105 350.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EDK37277.1 - 0.0011 18.1 0.0 0.0032 16.6 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EDK37277.1 - 0.0016 17.4 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Gp-FAR-1 PF05823.7 EDK37277.1 - 0.018 15.0 0.1 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) RNR_inhib PF08591.5 EDK37278.1 - 1.3e-17 64.4 0.1 3.3e-17 63.1 0.1 1.7 1 1 0 1 1 1 1 Ribonucleotide reductase inhibitor SUR7 PF06687.7 EDK37279.2 - 3.8e-21 75.6 5.7 5e-21 75.2 3.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 EDK37279.2 - 0.0031 17.4 1.6 0.0031 17.4 1.1 1.7 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SLAC1 PF03595.12 EDK37280.2 - 0.083 11.5 6.8 0.11 11.1 3.8 1.7 2 0 0 2 2 2 0 Voltage-dependent anion channel T2SF PF00482.18 EDK37280.2 - 0.11 12.4 0.2 6.2 6.7 0.0 2.8 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F DUF4271 PF14093.1 EDK37280.2 - 0.17 11.5 5.4 0.18 11.4 1.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) Cys_Met_Meta_PP PF01053.15 EDK37281.2 - 4.7e-143 476.1 0.0 5.3e-143 475.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EDK37281.2 - 2e-10 40.1 0.0 3.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EDK37281.2 - 3.3e-10 39.5 0.0 8.9e-10 38.1 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 EDK37281.2 - 9.1e-08 31.2 0.1 1.4e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.6 EDK37281.2 - 0.00028 19.2 0.2 0.00047 18.5 0.1 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.16 EDK37281.2 - 0.0012 18.1 0.0 0.0021 17.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 EDK37281.2 - 0.014 14.1 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Apc9 PF12856.2 EDK37282.2 - 0.11 12.5 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 Corona_NS2 PF04753.7 EDK37282.2 - 1.2 9.0 6.1 1.3 8.9 3.5 1.5 1 1 0 1 1 1 0 Coronavirus non-structural protein NS2 DEAD PF00270.24 EDK37283.2 - 1.3e-34 119.0 0.1 2.4e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK37283.2 - 1.1e-22 79.7 0.0 3.3e-22 78.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK37283.2 - 1.7e-07 31.2 0.1 5e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 EDK37283.2 - 0.0079 15.2 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit P5CR_dimer PF14748.1 EDK37284.2 - 5.9e-35 119.5 0.7 9.8e-35 118.8 0.5 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 EDK37284.2 - 3.5e-16 59.4 0.0 8.3e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.10 EDK37284.2 - 1.2e-05 24.3 0.0 1.5e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family NAD_Gly3P_dh_N PF01210.18 EDK37284.2 - 0.0012 18.5 0.4 0.0048 16.6 0.2 1.9 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 EDK37284.2 - 0.0016 17.8 0.1 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Saccharop_dh PF03435.13 EDK37284.2 - 0.0077 15.2 0.1 0.0099 14.8 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 EDK37284.2 - 0.053 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 EDK37284.2 - 0.079 12.9 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain JmjC PF02373.17 EDK37285.2 - 2.8e-39 133.8 1.5 3.6e-39 133.5 0.1 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase PHD PF00628.24 EDK37285.2 - 3.4e-12 45.8 6.5 3.4e-12 45.8 4.5 2.1 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.12 EDK37285.2 - 1.4e-11 43.6 0.1 4.6e-11 42.0 0.0 2.0 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.1 EDK37285.2 - 0.00075 18.7 0.7 0.0027 17.0 0.5 2.0 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.1 EDK37285.2 - 0.005 16.5 0.9 0.014 15.0 0.6 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 ARID PF01388.16 EDK37285.2 - 0.014 15.2 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain C1_1 PF00130.17 EDK37285.2 - 0.041 13.6 1.8 0.086 12.5 0.2 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.1 EDK37285.2 - 0.05 13.6 1.2 0.19 11.7 0.8 2.0 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_2 PF13639.1 EDK37285.2 - 0.24 11.2 7.5 2.8 7.8 5.2 2.7 1 1 0 1 1 1 0 Ring finger domain ATP-synt_ab PF00006.20 EDK37286.2 - 9.2e-63 211.6 0.0 1.3e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EDK37286.2 - 6.5e-27 94.2 0.2 1.1e-26 93.4 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EDK37286.2 - 1.6e-22 79.5 0.7 7.5e-22 77.3 0.5 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 EDK37286.2 - 0.00087 18.4 0.2 0.0015 17.6 0.1 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 EDK37286.2 - 0.0047 16.3 0.1 0.016 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 EDK37286.2 - 0.016 14.8 0.1 0.54 9.9 0.0 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 EDK37286.2 - 0.029 14.0 0.1 0.074 12.6 0.1 1.6 1 0 0 1 1 1 0 NACHT domain DUF258 PF03193.11 EDK37286.2 - 0.041 13.0 0.1 0.078 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK37286.2 - 0.053 13.4 0.1 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.17 EDK37286.2 - 0.077 11.8 0.5 0.5 9.1 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 EDK37286.2 - 0.087 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Arch_ATPase PF01637.13 EDK37286.2 - 0.089 12.4 0.0 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Archaeal ATPase AAA PF00004.24 EDK37286.2 - 0.091 12.9 0.1 1.4 9.0 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK37286.2 - 0.12 12.4 0.0 0.45 10.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain Peptidase_M48 PF01435.13 EDK37287.1 - 3.2e-50 170.7 0.5 4e-50 170.4 0.3 1.1 1 0 0 1 1 1 1 Peptidase family M48 DUF2201_N PF13203.1 EDK37287.1 - 0.012 14.8 0.5 0.02 14.1 0.4 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Flavin_Reduct PF01613.13 EDK37287.1 - 0.019 14.8 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Flavin reductase like domain Zn_peptidase_2 PF04298.7 EDK37287.1 - 0.066 12.5 1.1 0.068 12.5 0.1 1.5 2 0 0 2 2 2 0 Putative neutral zinc metallopeptidase Peptidase_M57 PF12388.3 EDK37287.1 - 0.075 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF684 PF05075.9 EDK37287.1 - 0.093 11.3 0.7 0.16 10.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF684) DUF955 PF06114.8 EDK37287.1 - 0.16 11.7 0.5 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF955) LUC7 PF03194.10 EDK37288.1 - 3.8e-69 233.0 8.1 4.7e-69 232.7 5.6 1.0 1 0 0 1 1 1 1 LUC7 N_terminus F-box-like PF12937.2 EDK37289.2 - 1.6e-09 37.3 0.4 3.4e-09 36.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK37289.2 - 1.4e-05 24.6 0.4 4.7e-05 22.9 0.3 1.9 1 0 0 1 1 1 1 F-box domain Glyco_hydro_72 PF03198.9 EDK37290.2 - 1.2e-23 83.5 0.0 1.8e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Peptidase_M28 PF04389.12 EDK37291.2 - 3.1e-30 105.2 0.0 1.1e-29 103.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 EDK37291.2 - 0.0074 15.8 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 EDK37291.2 - 0.054 12.2 0.0 0.25 10.0 0.0 1.8 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase URO-D PF01208.12 EDK37292.2 - 1.6e-85 287.0 0.0 1.8e-85 286.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ank_5 PF13857.1 EDK37293.2 - 3e-05 24.1 0.0 6.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EDK37293.2 - 0.00018 21.1 1.1 0.00038 20.1 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 EDK37293.2 - 0.0055 17.1 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK37293.2 - 0.0084 16.4 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) E2_bind PF08825.5 EDK37293.2 - 0.014 15.0 1.9 0.81 9.4 0.1 2.6 2 0 0 2 2 2 0 E2 binding domain DUF1664 PF07889.7 EDK37293.2 - 0.035 13.8 1.0 0.14 11.9 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SNF2_N PF00176.18 EDK37294.2 - 1.2e-55 188.3 0.0 1.7e-55 187.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EDK37294.2 - 9.2e-13 48.4 0.1 3.8e-11 43.1 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EDK37294.2 - 2.1e-12 46.7 0.0 4.8e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK37294.2 - 1.4e-10 40.9 0.2 3.2e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2428 PF10350.4 EDK37295.2 - 5.3e-66 222.2 4.0 9.6e-66 221.3 0.9 2.5 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 EDK37295.2 - 0.0013 18.6 0.9 15 6.0 0.0 6.8 7 0 0 7 7 7 1 HEAT repeat TPR_19 PF14559.1 EDK37295.2 - 0.014 15.6 0.3 5 7.5 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Lactamase_B_2 PF12706.2 EDK37296.2 - 1.2e-15 57.6 0.0 3.6e-15 56.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain DRMBL PF07522.9 EDK37296.2 - 0.00023 21.1 0.1 0.00079 19.4 0.1 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.22 EDK37296.2 - 0.0013 18.4 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DAGK_acc PF00609.14 EDK37296.2 - 0.0025 17.9 0.0 0.0056 16.8 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain RMMBL PF07521.7 EDK37296.2 - 0.003 17.3 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 EDK37296.2 - 0.053 13.2 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain TFIIS_C PF01096.13 EDK37297.2 - 1.7e-22 78.7 2.2 1.7e-22 78.7 1.5 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 EDK37297.2 - 1.1e-06 28.1 3.9 1.1e-06 28.1 2.7 2.2 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.2 EDK37297.2 - 0.019 14.7 0.4 0.019 14.7 0.3 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain DUF2387 PF09526.5 EDK37297.2 - 0.041 13.7 4.6 0.91 9.4 0.1 2.3 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) Baculo_LEF5_C PF11792.3 EDK37297.2 - 0.052 12.9 0.3 0.052 12.9 0.2 2.6 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain C1_1 PF00130.17 EDK37297.2 - 0.29 10.9 5.7 0.25 11.1 1.0 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Elf1 PF05129.8 EDK37297.2 - 0.33 10.6 3.9 3.3 7.4 0.2 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DZR PF12773.2 EDK37297.2 - 0.55 10.0 8.2 1.4 8.7 0.6 2.5 2 1 0 2 2 2 0 Double zinc ribbon zinc_ribbon_5 PF13719.1 EDK37297.2 - 7.4 6.2 9.9 3.7 7.2 1.0 3.3 4 0 0 4 4 4 0 zinc-ribbon domain IBR PF01485.16 EDK37297.2 - 8.7 6.3 12.5 2.1 8.3 0.9 3.0 2 1 0 2 2 2 0 IBR domain ORC2 PF04084.9 EDK37298.2 - 8.3e-107 356.7 3.1 1.4e-106 356.0 2.1 1.3 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Pkinase PF00069.20 EDK37299.2 - 4.2e-39 134.2 0.1 2.6e-38 131.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37299.2 - 5.9e-26 91.0 0.0 9.7e-26 90.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EDK37299.2 - 6.7e-07 28.5 0.0 1.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EDK37299.2 - 0.022 13.7 0.0 0.059 12.3 0.0 1.8 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 EDK37299.2 - 0.095 12.4 0.0 7 6.3 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family TPR_11 PF13414.1 EDK37300.2 - 6.3e-10 38.5 6.0 8.6e-07 28.5 0.1 4.6 3 1 2 5 5 5 2 TPR repeat TPR_1 PF00515.23 EDK37300.2 - 1.9e-05 24.0 0.3 0.68 9.6 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK37300.2 - 3.1e-05 23.8 1.6 0.26 11.2 0.0 4.5 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 EDK37300.2 - 0.0011 18.9 4.7 0.5 10.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37300.2 - 0.0013 19.3 1.8 2.2 9.0 0.0 4.3 3 1 2 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK37300.2 - 0.0019 18.6 4.0 1.1 10.1 0.1 5.2 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK37300.2 - 0.0023 18.2 0.3 1.9 8.8 0.1 4.3 3 2 1 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.4 EDK37300.2 - 0.0069 15.7 1.4 19 4.5 0.0 4.0 4 0 0 4 4 4 0 26S proteasome subunit RPN7 TPR_2 PF07719.12 EDK37300.2 - 0.01 15.6 8.3 18 5.5 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat Apc3 PF12895.2 EDK37300.2 - 0.036 14.1 1.8 1.3 9.2 0.1 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EDK37300.2 - 0.2 11.5 8.0 3.9 7.4 0.0 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Mg_trans_NIPA PF05653.9 EDK37302.2 - 3.4e-113 377.5 15.9 4.2e-113 377.2 11.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 EDK37302.2 - 2.4e-07 30.9 2.0 2.4e-07 30.9 1.4 2.9 2 1 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 EDK37302.2 - 0.00044 20.2 7.6 0.00044 20.2 5.3 2.8 2 1 0 2 2 2 1 EamA-like transporter family DUF2937 PF11157.3 EDK37302.2 - 0.029 13.6 1.2 0.039 13.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) eIF-1a PF01176.14 EDK37303.1 - 9.9e-27 92.1 0.4 1.4e-26 91.6 0.3 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CTK3 PF12243.3 EDK37304.2 - 2e-49 166.7 2.4 3e-49 166.2 1.2 1.6 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 EDK37304.2 - 1.8e-24 85.5 0.7 1.8e-24 85.5 0.5 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus Glyco_transf_20 PF00982.16 EDK37305.2 - 2.3e-147 491.3 0.0 3.1e-147 490.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EDK37305.2 - 2.7e-19 68.9 0.0 5.9e-19 67.9 0.0 1.6 1 0 0 1 1 1 1 Trehalose-phosphatase TatD_DNase PF01026.16 EDK37306.2 - 1.7e-35 122.4 0.0 2.2e-35 122.0 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase TIM PF00121.13 EDK37307.1 - 9.1e-89 296.7 0.0 1e-88 296.5 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase His_Phos_1 PF00300.17 EDK37308.2 - 5.8e-32 110.9 0.0 1e-31 110.1 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PAN_4 PF14295.1 EDK37308.2 - 0.035 13.8 0.5 0.086 12.5 0.3 1.7 1 0 0 1 1 1 0 PAN domain tRNA-synt_2 PF00152.15 EDK37310.2 - 7.9e-87 291.1 0.2 7.9e-87 291.1 0.2 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK37310.2 - 1.6e-10 40.6 0.0 3.1e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 EDK37310.2 - 9.5e-08 31.5 0.1 0.0013 17.9 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FtsJ PF01728.14 EDK37311.2 - 1.2e-64 217.6 0.0 1.5e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 EDK37311.2 - 0.013 16.1 0.0 0.071 13.6 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_S10 PF00338.17 EDK37312.2 - 4.2e-19 68.2 0.0 8.3e-19 67.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FAD-oxidase_C PF02913.14 EDK37314.2 - 5.6e-52 176.5 0.0 7.8e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EDK37314.2 - 3.4e-41 139.9 0.5 6.1e-41 139.1 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain GTP_EFTU PF00009.22 EDK37316.2 - 1.4e-06 27.8 0.0 0.00089 18.7 0.0 2.7 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK37316.2 - 4.7e-05 23.3 0.0 0.00013 21.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EDK37316.2 - 0.00046 20.0 0.3 0.0015 18.3 0.2 1.8 1 1 0 1 1 1 1 Dynamin family Septin PF00735.13 EDK37316.2 - 0.027 13.5 0.1 1.8 7.4 0.1 2.3 2 0 0 2 2 2 0 Septin AAA_29 PF13555.1 EDK37316.2 - 0.036 13.6 0.5 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.1 EDK37316.2 - 0.043 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK37316.2 - 0.088 12.2 0.1 11 5.4 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TPR_11 PF13414.1 EDK37317.2 - 1.4e-20 72.7 25.0 1.5e-08 34.1 2.1 5.9 3 2 3 6 6 6 6 TPR repeat TPR_1 PF00515.23 EDK37317.2 - 9.9e-14 50.2 9.0 0.00022 20.6 0.1 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.12 EDK37317.2 - 1.2e-12 46.7 22.2 0.00028 20.5 0.1 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37317.2 - 4.3e-11 43.1 27.7 9.1e-05 23.0 5.2 6.6 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 EDK37317.2 - 4.6e-09 36.1 30.9 0.22 12.2 1.4 8.0 5 2 3 8 8 8 4 Tetratricopeptide repeat Apc3 PF12895.2 EDK37317.2 - 2.7e-08 33.8 1.9 0.00033 20.7 0.1 2.9 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 EDK37317.2 - 2e-07 30.6 15.1 0.48 10.7 0.1 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK37317.2 - 3.6e-07 30.0 25.3 0.016 15.0 0.1 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK37317.2 - 4.8e-06 25.9 0.2 0.46 10.3 0.1 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK37317.2 - 7e-06 26.2 0.6 8.9e-05 22.7 0.0 5.3 4 1 2 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 EDK37317.2 - 5.8e-05 22.8 15.0 0.022 14.6 0.1 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 EDK37317.2 - 0.00016 20.8 7.7 0.054 12.5 0.3 4.2 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 EDK37317.2 - 0.00048 19.7 13.8 7 6.7 0.1 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat FimP PF09766.4 EDK37317.2 - 0.01 14.9 15.1 0.015 14.3 5.0 2.3 2 0 0 2 2 2 0 Fms-interacting protein Neur_chan_memb PF02932.11 EDK37317.2 - 0.015 15.1 0.0 0.03 14.1 0.0 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ycf1 PF05758.7 EDK37317.2 - 0.75 7.4 13.6 0.15 9.7 6.1 1.8 2 0 0 2 2 2 0 Ycf1 TPR_6 PF13174.1 EDK37317.2 - 1.7 9.2 16.1 2.1 8.9 0.4 5.5 6 0 0 6 6 4 0 Tetratricopeptide repeat Inhibitor_I71 PF12628.2 EDK37317.2 - 3 7.4 7.5 0.83 9.2 0.4 2.2 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor AAA_23 PF13476.1 EDK37317.2 - 3.9 7.7 12.8 6.3 7.0 7.8 1.9 2 0 0 2 2 2 0 AAA domain Suf PF05843.9 EDK37317.2 - 5.3 6.6 12.3 9.1 5.9 6.2 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) HAD PF12710.2 EDK37318.2 - 2.1e-19 70.4 0.0 2.8e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 EDK37318.2 - 9.1e-07 28.4 0.1 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.7 EDK37318.2 - 0.0035 16.5 0.0 0.46 9.6 0.0 2.8 3 0 0 3 3 3 1 Putative Phosphatase HAD_2 PF13419.1 EDK37318.2 - 0.073 13.2 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Peptidase_M20 PF01546.23 EDK37319.2 - 1.4e-24 86.6 0.1 2e-24 86.1 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK37319.2 - 4e-19 68.4 0.0 6.4e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EDK37319.2 - 0.049 13.3 0.1 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 DUF3212 PF11486.3 EDK37319.2 - 0.059 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) DUF2373 PF10180.4 EDK37320.2 - 8.6e-25 86.0 0.5 1.6e-24 85.2 0.4 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) TIP120 PF08623.5 EDK37321.2 - 2.4e-44 150.8 0.0 1.7e-43 148.1 0.0 2.5 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 EDK37321.2 - 4.2e-09 36.5 5.5 6.9e-05 23.0 0.0 5.0 6 0 0 6 6 6 2 HEAT repeats HEAT PF02985.17 EDK37321.2 - 3.3e-07 29.8 7.4 0.0064 16.4 0.0 6.9 6 1 1 7 7 7 1 HEAT repeat HEAT_EZ PF13513.1 EDK37321.2 - 0.0002 21.7 1.4 5.3 7.6 0.0 5.4 5 0 0 5 5 5 1 HEAT-like repeat DUF2435 PF10363.4 EDK37321.2 - 0.00023 20.9 1.7 0.093 12.6 0.1 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF2435) DNA_pol_B_palm PF14792.1 EDK37321.2 - 0.012 15.7 0.9 0.092 12.8 0.0 3.0 3 0 0 3 3 3 0 DNA polymerase beta palm Condensin2nSMC PF12422.3 EDK37321.2 - 0.013 15.2 0.3 0.081 12.6 0.0 2.5 2 1 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit ATP_bind_3 PF01171.15 EDK37321.2 - 0.034 13.6 0.4 2.4 7.6 0.1 2.6 2 0 0 2 2 2 0 PP-loop family Cnd1 PF12717.2 EDK37321.2 - 0.062 13.1 4.4 2 8.2 0.0 4.1 3 2 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 ELYS PF13934.1 EDK37321.2 - 0.16 11.7 4.9 2.5 7.7 0.4 3.3 2 1 1 3 3 3 0 Nuclear pore complex assembly Arm PF00514.18 EDK37321.2 - 1.4 8.8 4.7 9.1 6.2 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Aconitase PF00330.15 EDK37322.2 - 3.2e-79 266.5 1.3 2.4e-50 171.3 0.1 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EDK37322.2 - 6.5e-29 100.6 0.0 1.4e-28 99.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Myco_19_kDa PF05481.7 EDK37322.2 - 0.003 17.4 0.4 0.0094 15.7 0.3 1.8 1 0 0 1 1 1 1 Mycobacterium 19 kDa lipoprotein antigen DUF521 PF04412.8 EDK37322.2 - 0.053 12.0 0.0 0.095 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Abi PF02517.11 EDK37323.2 - 9.3e-14 51.3 2.1 9.3e-14 51.3 1.5 2.6 3 1 0 3 3 3 1 CAAX protease self-immunity DUF1543 PF07566.7 EDK37324.2 - 0.08 12.4 0.1 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1543) Zds_C PF08632.5 EDK37325.2 - 6.7e-31 105.4 1.7 1.2e-30 104.6 1.2 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Cyt-b5 PF00173.23 EDK37326.1 - 3.7e-19 68.2 0.4 1.8e-18 66.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 EDK37326.1 - 3.5e-10 40.2 21.4 7.3e-10 39.2 13.4 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily COX14 PF14880.1 EDK37326.1 - 0.64 9.6 4.1 23 4.6 1.4 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly RRN9 PF10680.4 EDK37327.2 - 2.5e-16 59.1 0.6 7.9e-16 57.5 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor CAF-1_p150 PF11600.3 EDK37327.2 - 0.68 9.2 14.5 1.5 8.1 10.1 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ndc1_Nup PF09531.5 EDK37327.2 - 1.9 6.7 6.2 3.1 6.0 4.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pribosyltran PF00156.22 EDK37328.2 - 3.2e-18 65.6 0.2 6.1e-18 64.7 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain SRP19 PF01922.12 EDK37329.1 - 1.7e-31 108.6 0.0 4e-31 107.4 0.0 1.7 1 0 0 1 1 1 1 SRP19 protein DUF3600 PF12207.3 EDK37329.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3600) DUF294_C PF10335.4 EDK37329.1 - 0.15 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain zf-C3HC PF07967.8 EDK37330.2 - 4.2e-38 130.1 6.2 2.2e-36 124.5 0.8 2.4 2 0 0 2 2 2 2 C3HC zinc finger-like A2L_zn_ribbon PF08792.5 EDK37330.2 - 0.11 11.9 1.9 2.1 7.8 0.2 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain WD40 PF00400.27 EDK37331.2 - 8e-45 149.1 9.0 3.7e-10 39.2 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 EDK37331.2 - 6.7e-07 28.9 0.1 1.5e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK37331.2 - 1.4e-06 27.7 0.0 3.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.3 EDK37331.2 - 0.00052 18.2 6.2 0.3 9.1 0.0 4.7 4 1 1 5 5 5 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 EDK37331.2 - 0.0013 18.4 0.1 1.2 8.9 0.0 3.7 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.1 EDK37331.2 - 0.0019 17.7 0.8 1 8.7 0.1 2.7 1 1 1 2 2 2 2 PQQ-like domain tRNA-synt_1 PF00133.17 EDK37332.2 - 3.4e-43 147.5 0.0 1.4e-33 115.7 0.0 2.7 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 EDK37332.2 - 1.8e-19 69.7 0.1 5e-10 38.6 0.0 3.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 EDK37332.2 - 4.3e-12 46.0 0.0 1.4e-11 44.4 0.0 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 EDK37332.2 - 3.2e-08 33.0 0.0 8.4e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.1 EDK37332.2 - 0.00098 18.4 0.0 0.0041 16.4 0.0 2.1 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 RRM_1 PF00076.17 EDK37333.2 - 1.9e-47 158.7 0.6 7.6e-15 54.3 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37333.2 - 8.9e-44 147.3 0.1 1.6e-12 47.2 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37333.2 - 4.9e-20 71.1 0.0 1.7e-05 24.6 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK37333.2 - 2e-09 37.0 0.0 0.0047 16.6 0.0 4.3 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 EDK37333.2 - 5.6e-08 32.4 0.1 0.88 9.3 0.0 4.8 3 2 1 4 4 4 3 Nup53/35/40-type RNA recognition motif DUF4283 PF14111.1 EDK37333.2 - 0.00036 19.6 0.0 0.25 10.4 0.0 3.4 2 2 1 3 3 3 2 Domain of unknown function (DUF4283) DUF1866 PF08952.6 EDK37333.2 - 0.014 14.9 0.0 0.96 8.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) G-patch PF01585.18 EDK37334.1 - 0.0001 22.0 2.1 0.00079 19.1 1.4 2.6 1 0 0 1 1 1 1 G-patch domain DUF1514 PF07438.6 EDK37334.1 - 0.14 12.1 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) SprA-related PF12118.3 EDK37334.1 - 0.86 8.8 32.2 1.4 8.2 22.3 1.4 1 0 0 1 1 1 0 SprA-related family PXA PF02194.10 EDK37335.2 - 8e-46 155.9 0.5 2.4e-45 154.3 0.3 1.9 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.7 EDK37335.2 - 1.1e-24 86.7 0.0 3.2e-24 85.1 0.0 1.9 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.19 EDK37335.2 - 2.4e-18 65.9 0.2 8.5e-18 64.2 0.1 2.0 1 0 0 1 1 1 1 PX domain RGS PF00615.14 EDK37335.2 - 5.1e-05 23.3 0.6 5.1e-05 23.3 0.4 3.4 4 0 0 4 4 4 1 Regulator of G protein signaling domain WW PF00397.21 EDK37336.2 - 9.6e-08 31.7 0.9 1.7e-07 30.9 0.6 1.4 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.4 EDK37336.2 - 6.5 6.7 16.9 12 5.8 11.7 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ETC_C1_NDUFA5 PF04716.9 EDK37337.2 - 4.2e-26 90.2 0.6 8.4e-26 89.2 0.4 1.5 1 0 0 1 1 1 1 ETC complex I subunit conserved region DUF2887 PF11103.3 EDK37337.2 - 0.069 12.7 0.2 0.089 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) DALR_1 PF05746.10 EDK37337.2 - 0.086 12.8 0.4 0.53 10.2 0.0 2.0 1 1 1 2 2 2 0 DALR anticodon binding domain Put_DNA-bind_N PF06971.8 EDK37337.2 - 0.34 10.7 2.1 0.34 10.6 0.4 1.8 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus Ras PF00071.17 EDK37339.2 - 1.8e-64 215.9 0.2 2.1e-64 215.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK37339.2 - 2.3e-19 70.0 0.0 3.6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK37339.2 - 4.1e-16 58.6 0.0 5.1e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK37339.2 - 2.7e-08 33.2 0.1 3.2e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EDK37339.2 - 1.9e-07 30.7 0.1 4.3e-07 29.5 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 EDK37339.2 - 0.00015 21.0 0.0 0.00018 20.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EDK37339.2 - 0.00018 21.4 0.0 0.00044 20.1 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK37339.2 - 0.00065 19.0 0.0 0.0031 16.7 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.15 EDK37339.2 - 0.0021 16.8 0.2 1.5 7.3 0.0 2.7 1 1 1 2 2 2 2 G-protein alpha subunit AAA_22 PF13401.1 EDK37339.2 - 0.0031 17.6 0.1 0.034 14.3 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK37339.2 - 0.0054 16.7 0.0 0.056 13.4 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Septin PF00735.13 EDK37339.2 - 0.012 14.6 0.0 0.026 13.5 0.0 1.5 1 0 0 1 1 1 0 Septin DUF258 PF03193.11 EDK37339.2 - 0.02 14.1 0.0 0.037 13.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 EDK37339.2 - 0.028 13.9 0.0 0.087 12.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain MCM PF00493.18 EDK37339.2 - 0.1 11.3 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family AAA_14 PF13173.1 EDK37339.2 - 0.13 12.1 0.1 0.26 11.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain B3_4 PF03483.12 EDK37340.1 - 1.7e-27 96.0 0.0 3.5e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 EDK37340.1 - 3.4e-21 74.8 0.0 2.3e-16 59.3 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain Herpes_V23 PF01802.12 EDK37340.1 - 0.068 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein DUF726 PF05277.7 EDK37341.2 - 1.3e-133 445.2 2.0 1.8e-133 444.7 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) DUF3115 PF11312.3 EDK37342.2 - 3.2e-103 344.8 0.2 3.9e-103 344.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) Methyltransf_25 PF13649.1 EDK37342.2 - 0.031 14.6 0.2 0.17 12.2 0.0 2.4 3 1 0 3 3 3 0 Methyltransferase domain SIR2 PF02146.12 EDK37343.2 - 1e-58 197.9 0.0 1.7e-58 197.2 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF3441 PF11923.3 EDK37344.2 - 7e-35 119.0 0.0 7e-35 119.0 0.0 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 EDK37344.2 - 3.6e-11 42.7 0.1 1.4e-10 40.8 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF814) NESP55 PF06390.7 EDK37344.2 - 0.004 16.5 6.8 0.004 16.5 4.7 3.3 3 1 0 3 3 3 1 Neuroendocrine-specific golgi protein P55 (NESP55) His_Phos_2 PF00328.17 EDK37345.2 - 1.5e-41 142.9 0.0 1.7e-41 142.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PTR2 PF00854.16 EDK37346.1 - 5.9e-45 153.6 4.0 5.9e-45 153.6 2.8 1.5 1 1 0 1 1 1 1 POT family zf-like PF04071.7 EDK37346.1 - 0.024 14.3 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich small domain GST_C PF00043.20 EDK37347.2 - 7.2e-17 61.1 0.0 1.3e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 EDK37347.2 - 2.9e-14 52.9 0.0 5.6e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EDK37347.2 - 3.3e-11 43.0 0.0 6.2e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 EDK37347.2 - 3.7e-10 39.8 0.0 7.6e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EDK37347.2 - 0.008 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tbf5 PF06331.7 EDK37348.2 - 0.072 12.8 0.1 0.22 11.3 0.1 1.8 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 Cyt-b5 PF00173.23 EDK37349.1 - 8.6e-11 41.4 0.0 1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain U1snRNP70_N PF12220.3 EDK37350.2 - 1.7e-25 89.1 6.6 3.3e-25 88.2 4.6 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 EDK37350.2 - 3.7e-16 58.5 0.1 7.7e-16 57.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37350.2 - 4.5e-09 36.1 0.0 9.3e-09 35.1 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37350.2 - 7.1e-05 22.5 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ran_BP1 PF00638.13 EDK37351.2 - 1.3e-24 86.5 0.0 2.3e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Mucin PF01456.12 EDK37351.2 - 4.4 7.0 18.8 8.1 6.2 13.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Methyltransf_31 PF13847.1 EDK37352.2 - 6.2e-22 77.8 0.0 8.4e-22 77.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK37352.2 - 9.9e-15 55.0 0.0 1.5e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK37352.2 - 1.4e-09 38.3 0.1 2.8e-09 37.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EDK37352.2 - 1.5e-07 31.2 0.0 1.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK37352.2 - 6.1e-07 29.7 0.1 4e-06 27.1 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK37352.2 - 2.4e-06 27.5 0.0 3.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK37352.2 - 7.2e-06 26.4 0.0 1.1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK37352.2 - 0.00082 19.1 0.0 0.0011 18.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK37352.2 - 0.00098 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 EDK37352.2 - 0.0081 15.5 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.9 EDK37352.2 - 0.063 12.4 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB CAF1C_H4-bd PF12265.3 EDK37353.2 - 2.4e-22 78.6 0.1 7.7e-22 76.9 0.0 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 EDK37353.2 - 2.9e-20 71.3 21.2 1e-07 31.5 0.5 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EDK37353.2 - 4.3e-08 33.0 2.4 8e-06 25.7 0.1 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 EDK37353.2 - 0.001 18.7 0.1 0.031 14.0 0.0 2.9 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Mt_ATP-synt_B PF05405.9 EDK37354.2 - 9.7e-49 164.9 10.2 1.2e-48 164.6 7.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DivIC PF04977.10 EDK37354.2 - 0.017 14.5 0.4 0.017 14.5 0.3 2.2 1 1 1 2 2 2 0 Septum formation initiator Uteroglobin PF01099.12 EDK37354.2 - 0.074 12.8 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Uteroglobin family FcoT PF10862.3 EDK37354.2 - 0.14 11.6 0.6 0.3 10.6 0.3 1.6 2 0 0 2 2 2 0 FcoT-like thioesterase domain DASH_Duo1 PF08651.5 EDK37354.2 - 1 8.9 6.9 5.1 6.7 0.5 3.0 2 1 1 3 3 3 0 DASH complex subunit Duo1 Abhydrolase_6 PF12697.2 EDK37355.2 - 3e-21 76.3 0.0 4.1e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK37355.2 - 4.6e-07 29.6 0.0 1.2e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK37355.2 - 4.2e-06 26.4 0.1 1e-05 25.1 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EDK37355.2 - 8.8e-05 21.8 0.0 0.00017 20.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.15 EDK37355.2 - 0.0018 17.7 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 Putative esterase DUF2920 PF11144.3 EDK37355.2 - 0.018 14.1 0.1 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Abhydrolase_2 PF02230.11 EDK37355.2 - 0.037 13.4 1.1 0.4 10.0 0.0 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase DUF500 PF04366.7 EDK37355.2 - 0.06 12.7 0.0 0.55 9.6 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF500) Palm_thioest PF02089.10 EDK37356.2 - 3.3e-52 177.1 0.0 4.1e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.2 EDK37356.2 - 0.00075 19.4 0.0 0.00093 19.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 EDK37356.2 - 0.0014 18.0 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EDK37356.2 - 0.0029 17.2 0.0 0.0043 16.6 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.11 EDK37356.2 - 0.0072 15.7 0.1 1.6 8.0 0.1 2.2 1 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 EDK37356.2 - 0.021 14.3 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold FSH1 PF03959.8 EDK37356.2 - 0.092 12.1 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Ribosomal_L1 PF00687.16 EDK37357.2 - 5.4e-47 159.9 4.5 6.6e-47 159.6 3.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Sec7_N PF12783.2 EDK37357.2 - 0.03 13.7 0.2 0.055 12.8 0.1 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal AA_permease_2 PF13520.1 EDK37358.2 - 1.9e-48 165.0 45.6 2.4e-48 164.7 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK37358.2 - 5.8e-34 117.2 41.8 7.8e-34 116.8 29.0 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3353 PF11833.3 EDK37358.2 - 1.6 8.1 6.6 6.2 6.2 4.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3353) Tim17 PF02466.14 EDK37359.1 - 3.3e-32 111.2 7.1 4.1e-32 110.9 4.9 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF3180 PF11377.3 EDK37359.1 - 3 7.7 8.5 7 6.5 0.6 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3180) Pkinase PF00069.20 EDK37361.2 - 6.7e-55 186.0 0.3 4.1e-54 183.4 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37361.2 - 2.2e-22 79.3 0.2 1.2e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EDK37361.2 - 8.6e-05 22.3 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EDK37361.2 - 0.0044 16.6 0.3 0.0044 16.6 0.2 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 EDK37361.2 - 0.0091 15.0 0.5 0.023 13.7 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EDK37361.2 - 0.013 14.8 0.1 0.013 14.8 0.1 1.7 2 0 0 2 2 2 0 RIO1 family YjcZ PF13990.1 EDK37361.2 - 0.022 13.9 0.0 2.7 7.0 0.0 2.3 2 0 0 2 2 2 0 YjcZ-like protein RNA_pol_Rpb4 PF03874.11 EDK37362.2 - 5.5e-31 106.9 1.9 7.2e-31 106.6 1.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Voldacs PF03517.8 EDK37362.2 - 0.06 13.1 1.9 0.097 12.5 1.3 1.4 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling GTP_EFTU PF00009.22 EDK37363.2 - 1e-10 41.4 0.0 1.5e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EDK37363.2 - 0.0045 17.4 0.0 0.0091 16.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 EDK37363.2 - 0.038 13.8 0.1 0.1 12.4 0.0 1.8 1 1 1 2 2 2 0 Dynamin family MMR_HSR1 PF01926.18 EDK37363.2 - 0.11 12.4 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase EFG_IV PF03764.13 EDK37364.2 - 8.1e-20 70.5 0.0 1.4e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 EDK37364.2 - 8.3e-16 57.6 0.0 1.9e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EDK37364.2 - 2.6e-08 33.8 0.6 5.9e-08 32.7 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EDK37364.2 - 4.3e-05 23.2 0.0 0.00011 21.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF2420 PF10336.4 EDK37365.2 - 9.5e-36 121.8 0.5 9.5e-36 121.8 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2420) SWIRM PF04433.12 EDK37366.2 - 1e-33 115.2 0.5 3.8e-33 113.4 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.26 EDK37366.2 - 5.5e-08 32.7 0.2 1.1e-07 31.7 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK37366.2 - 2e-06 27.7 0.1 6.9e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_L22 PF00237.14 EDK37367.1 - 6.2e-33 112.8 0.2 1.1e-32 112.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e UcrQ PF02939.11 EDK37368.1 - 1e-29 102.1 1.2 1.2e-29 101.9 0.8 1.0 1 0 0 1 1 1 1 UcrQ family DltD_C PF04914.7 EDK37368.1 - 0.081 12.7 0.0 0.085 12.7 0.0 1.2 1 0 0 1 1 1 0 DltD C-terminal region polyprenyl_synt PF00348.12 EDK37369.2 - 3e-70 236.0 0.0 3.9e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Ebp2 PF05890.7 EDK37370.2 - 4.6e-88 295.0 24.8 4.6e-88 295.0 17.2 2.0 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Glyco_transf_15 PF01793.11 EDK37371.2 - 1.1e-134 448.6 4.2 1.3e-134 448.3 2.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase MFS_1 PF07690.11 EDK37371.2 - 0.23 10.1 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily Complex1_51K PF01512.12 EDK37372.2 - 1e-46 158.3 0.0 1.4e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 EDK37373.2 - 1.2e-20 72.3 0.6 2.2e-20 71.5 0.4 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 EDK37373.2 - 2e-06 27.5 0.0 4.6e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 SLBB domain UPF0016 PF01169.14 EDK37375.1 - 1.5e-41 140.3 24.4 1.3e-21 76.5 5.0 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TerC PF03741.11 EDK37375.1 - 0.0067 15.8 0.7 0.0067 15.8 0.5 2.4 2 0 0 2 2 2 1 Integral membrane protein TerC family DUF2448 PF10476.4 EDK37375.1 - 1 8.8 3.3 2.9 7.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) Med8 PF10232.4 EDK37376.1 - 6.7e-48 163.1 1.9 9e-48 162.7 1.3 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Allexi_40kDa PF05549.6 EDK37376.1 - 0.04 13.2 0.1 0.063 12.5 0.1 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Syntaxin_2 PF14523.1 EDK37376.1 - 0.046 13.7 1.7 0.093 12.7 1.2 1.5 1 0 0 1 1 1 0 Syntaxin-like protein NpwBP PF12622.2 EDK37377.1 - 2.2e-12 47.2 1.0 2.2e-12 47.2 0.7 2.2 1 1 1 2 2 2 1 mRNA biogenesis factor Wbp11 PF09429.5 EDK37377.1 - 0.0024 17.8 11.8 0.0024 17.8 8.2 2.1 3 0 0 3 3 3 1 WW domain binding protein 11 SpoIISB_antitox PF14185.1 EDK37377.1 - 0.084 12.6 0.1 0.084 12.6 0.1 2.3 3 0 0 3 3 3 0 Antitoxin SpoIISB, type II toxin-antitoxin system Mito_carr PF00153.22 EDK37378.1 - 3.2e-77 254.3 1.2 5.4e-27 93.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3535 PF12054.3 EDK37379.2 - 2.8e-151 504.0 4.5 2.8e-151 504.0 3.1 3.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 EDK37379.2 - 1.7e-74 250.3 0.0 3.2e-74 249.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK37379.2 - 1.2e-15 57.1 0.1 1.2e-13 50.6 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HEAT PF02985.17 EDK37379.2 - 8.8e-14 50.2 8.3 0.11 12.6 0.0 10.2 9 1 1 10 10 10 4 HEAT repeat HEAT_EZ PF13513.1 EDK37379.2 - 1.7e-09 37.8 9.1 0.89 10.1 0.0 9.1 9 0 0 9 9 9 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 EDK37379.2 - 3.7e-07 30.4 0.2 0.0083 16.4 0.0 4.4 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 EDK37379.2 - 0.00031 20.9 10.2 0.02 15.1 0.0 6.8 6 4 1 7 7 7 1 HEAT repeats DUF1014 PF06244.7 EDK37380.1 - 9.7e-28 96.8 15.2 7.3e-27 94.0 10.5 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) HTH_WhiA PF02650.9 EDK37380.1 - 0.38 11.1 0.1 0.38 11.1 0.1 3.1 2 2 2 4 4 4 0 WhiA C-terminal HTH domain ADH_N PF08240.7 EDK37381.2 - 9.5e-27 92.9 0.7 1.9e-26 91.9 0.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK37381.2 - 6.5e-16 58.0 0.0 1.3e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK37381.2 - 3.9e-08 34.2 0.0 6.2e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 EDK37381.2 - 9e-07 28.6 0.0 1.6e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 EDK37381.2 - 0.0011 18.1 0.0 0.0021 17.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.15 EDK37381.2 - 0.0061 16.4 0.0 0.0097 15.8 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Methyltransf_11 PF08241.7 EDK37381.2 - 0.013 15.9 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 EDK37381.2 - 0.084 13.4 0.0 0.22 12.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Shikimate_DH PF01488.15 EDK37381.2 - 0.09 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EDK37381.2 - 0.12 12.0 0.7 0.18 11.4 0.0 1.7 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 EDK37381.2 - 0.19 11.5 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 1 0 ThiF family HMGL-like PF00682.14 EDK37382.2 - 7.9e-75 251.5 0.4 1.1e-74 251.1 0.3 1.2 1 0 0 1 1 1 1 HMGL-like ADP_PFK_GK PF04587.10 EDK37382.2 - 0.014 13.6 0.0 0.021 13.0 0.0 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region TMF_TATA_bd PF12325.3 EDK37383.2 - 0.99 9.1 5.8 5.9 6.6 1.5 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Mur_ligase_M PF08245.7 EDK37384.2 - 0.0001 22.4 0.3 0.00078 19.5 0.2 2.5 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 EDK37384.2 - 0.003 17.5 0.0 0.042 13.8 0.0 2.4 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain DASH_Dad2 PF08654.5 EDK37385.2 - 0.042 13.8 3.3 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Dad2 Pkinase PF00069.20 EDK37386.2 - 5.3e-66 222.4 0.2 9.1e-66 221.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37386.2 - 2.9e-38 131.4 0.1 4.6e-38 130.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37386.2 - 6.6e-06 25.2 0.0 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK37386.2 - 0.00044 19.3 0.1 0.0028 16.7 0.0 2.2 2 1 1 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family SUV3_C PF12513.3 EDK37387.2 - 5e-16 57.8 0.8 1.2e-15 56.6 0.6 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 EDK37387.2 - 4.3e-13 48.9 0.0 1.7e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Helicase_C_4 PF13871.1 EDK37387.2 - 0.016 14.6 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Helicase_C-like SKI PF01202.17 EDK37388.2 - 1.2e-11 44.7 0.0 1.7e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_17 PF13207.1 EDK37388.2 - 1.9e-09 38.3 0.0 2.5e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK37388.2 - 1.1e-08 35.3 0.0 2.4e-08 34.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 EDK37388.2 - 9.9e-06 25.2 0.0 1.3e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 EDK37388.2 - 3.3e-05 23.7 0.0 6.1e-05 22.9 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 EDK37388.2 - 0.00017 21.2 0.0 0.00058 19.5 0.0 1.8 2 0 0 2 2 2 1 Part of AAA domain Thymidylate_kin PF02223.12 EDK37388.2 - 0.0012 18.2 0.0 0.25 10.7 0.0 2.3 2 1 0 2 2 2 1 Thymidylate kinase AAA PF00004.24 EDK37388.2 - 0.0021 18.2 0.2 0.0028 17.8 0.2 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 EDK37388.2 - 0.0046 16.2 0.3 0.0071 15.6 0.2 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.1 EDK37388.2 - 0.0059 16.7 0.1 0.019 15.0 0.1 2.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EDK37388.2 - 0.0092 15.0 0.1 0.015 14.4 0.1 1.4 1 1 0 1 1 1 1 Zeta toxin CPT PF07931.7 EDK37388.2 - 0.0093 15.6 0.0 0.36 10.4 0.0 2.1 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_30 PF13604.1 EDK37388.2 - 0.012 15.2 0.2 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EDK37388.2 - 0.012 15.6 0.1 0.025 14.5 0.0 1.6 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 EDK37388.2 - 0.028 14.4 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 EDK37388.2 - 0.032 14.5 0.1 0.049 13.9 0.0 1.6 1 1 0 1 1 1 0 ABC transporter PRK PF00485.13 EDK37388.2 - 0.032 13.7 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.9 EDK37388.2 - 0.04 13.6 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EDK37388.2 - 0.046 13.1 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EDK37388.2 - 0.046 13.1 0.1 0.078 12.3 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein CoaE PF01121.15 EDK37388.2 - 0.047 13.0 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_24 PF13479.1 EDK37388.2 - 0.065 12.8 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EDK37388.2 - 0.071 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Cytidylate_kin2 PF13189.1 EDK37388.2 - 0.073 12.9 0.0 0.8 9.5 0.0 2.2 1 1 0 2 2 2 0 Cytidylate kinase-like family T2SE PF00437.15 EDK37388.2 - 0.074 11.9 0.1 0.13 11.1 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NB-ARC PF00931.17 EDK37388.2 - 0.09 11.6 1.5 0.55 9.0 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.7 EDK37388.2 - 0.09 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 EDK37388.2 - 0.095 11.6 0.2 0.13 11.2 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.1 EDK37388.2 - 0.21 11.8 1.9 0.3 11.3 1.3 1.7 1 1 0 1 1 1 0 AAA domain adh_short PF00106.20 EDK37389.2 - 1.7e-11 44.3 0.0 5.6e-11 42.6 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK37389.2 - 0.095 12.3 0.0 0.18 11.4 0.0 1.5 1 1 0 1 1 1 0 KR domain SGT1 PF07093.6 EDK37390.2 - 5.6e-28 97.6 1.3 5.6e-28 97.6 0.9 2.5 2 1 0 2 2 2 2 SGT1 protein Flu_B_M2 PF04772.7 EDK37390.2 - 0.022 14.8 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) Thiolase_N PF00108.18 EDK37391.2 - 3.1e-99 331.2 1.7 4.3e-99 330.7 1.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 EDK37391.2 - 3.7e-46 155.5 0.4 8.8e-46 154.3 0.3 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 EDK37391.2 - 0.00018 21.0 0.3 0.00041 19.9 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 EDK37391.2 - 0.11 12.1 1.2 4.8 6.9 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.11 EDK37392.2 - 2.2e-26 92.4 41.0 2.2e-26 92.4 28.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_6 PF10746.4 EDK37392.2 - 3.2 7.5 5.3 8.8 6.1 0.2 3.2 3 0 0 3 3 3 0 Phage holin family 6 FLILHELTA PF10306.4 EDK37393.2 - 8.9e-34 115.3 1.2 1.2e-33 114.9 0.2 1.6 2 0 0 2 2 2 1 Hypothetical protein FLILHELTA Pkinase PF00069.20 EDK37394.2 - 1e-61 208.3 0.0 1.3e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37394.2 - 9.2e-23 80.6 0.0 1.2e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37394.2 - 0.00036 19.5 0.0 0.00078 18.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK37394.2 - 0.00079 19.2 0.0 0.0037 17.0 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 EDK37394.2 - 0.003 17.1 0.3 0.0072 15.9 0.2 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase LMBR1 PF04791.11 EDK37395.2 - 0.089 11.3 4.2 0.12 10.9 2.9 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.9 EDK37395.2 - 0.39 10.6 11.7 0.58 10.0 8.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DDRGK PF09756.4 EDK37395.2 - 1.1 8.6 25.3 0.43 9.9 15.8 1.6 2 0 0 2 2 2 0 DDRGK domain DUF1682 PF07946.9 EDK37395.2 - 1.4 7.6 17.2 2.4 6.9 11.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pkinase PF00069.20 EDK37396.2 - 6.4e-35 120.5 0.0 8.2e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37396.2 - 1.3e-18 67.0 0.0 1.6e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Herpes_UL33 PF03581.8 EDK37396.2 - 0.026 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL33-like protein Kinase-like PF14531.1 EDK37396.2 - 0.028 13.3 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.20 EDK37397.2 - 2.7e-64 216.8 0.1 3.7e-64 216.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37397.2 - 7.8e-32 110.3 0.5 4.8e-30 104.4 0.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37397.2 - 0.00045 19.2 0.0 0.00091 18.2 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Imm46 PF15585.1 EDK37397.2 - 0.0019 18.2 0.0 0.005 16.8 0.0 1.7 1 0 0 1 1 1 1 Immunity protein 46 Wzt_C PF14524.1 EDK37397.2 - 0.079 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Wzt C-terminal domain Porphobil_deam PF01379.15 EDK37399.2 - 2.1e-84 281.7 0.0 3e-84 281.2 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 EDK37399.2 - 2.2e-20 72.5 0.0 4.3e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF188 PF02639.9 EDK37399.2 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 SRP_SPB PF02978.14 EDK37400.2 - 0.065 13.4 0.2 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Signal peptide binding domain ERCC4 PF02732.10 EDK37401.2 - 3.2e-23 82.0 0.0 1.9e-22 79.5 0.0 2.4 2 0 0 2 2 2 1 ERCC4 domain MTHFR PF02219.12 EDK37403.2 - 5.1e-104 347.3 0.0 8.3e-104 346.6 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ATG27 PF09451.5 EDK37404.2 - 2.4e-70 236.8 1.4 2.9e-70 236.6 1.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 EDK37404.2 - 5.7e-07 29.3 1.7 5.1e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Ldh_1_N PF00056.18 EDK37405.2 - 4e-43 146.6 1.0 5.6e-43 146.1 0.7 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 EDK37405.2 - 1.3e-31 109.6 0.0 2.4e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF2520 PF10728.4 EDK37405.2 - 0.046 13.1 0.0 0.09 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2520) 3Beta_HSD PF01073.14 EDK37405.2 - 0.09 11.4 0.0 0.15 10.7 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family OpuAC PF04069.7 EDK37405.2 - 0.14 11.5 0.0 0.31 10.3 0.0 1.5 2 0 0 2 2 2 0 Substrate binding domain of ABC-type glycine betaine transport system Beta-lactamase PF00144.19 EDK37406.2 - 6.1e-41 140.5 0.0 9.5e-41 139.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Histidinol_dh PF00815.15 EDK37407.2 - 4.9e-181 601.8 5.5 5.9e-181 601.5 3.3 1.5 2 0 0 2 2 2 1 Histidinol dehydrogenase PRA-CH PF01502.13 EDK37407.2 - 1.7e-21 75.6 0.3 4e-21 74.4 0.2 1.7 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 EDK37407.2 - 5.2e-11 42.6 0.1 1.6e-10 41.0 0.1 1.8 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.12 EDK37407.2 - 0.02 14.8 0.3 0.045 13.6 0.2 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain TPR_11 PF13414.1 EDK37408.2 - 5.4e-23 80.4 8.8 4.5e-12 45.4 0.0 4.8 3 2 2 5 5 5 4 TPR repeat TPR_1 PF00515.23 EDK37408.2 - 2.8e-22 77.3 2.9 6.1e-06 25.6 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 EDK37408.2 - 4.2e-18 63.9 1.5 0.00064 19.7 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 EDK37408.2 - 1.8e-17 61.7 5.6 0.0015 18.2 0.0 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 EDK37408.2 - 1.8e-15 56.0 0.7 0.00088 19.7 0.0 5.7 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.1 EDK37408.2 - 1e-14 54.5 1.4 0.002 18.3 0.1 4.9 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37408.2 - 1e-11 45.1 0.3 6.6e-05 23.4 0.0 4.2 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_20 PF14561.1 EDK37408.2 - 5.1e-09 36.1 0.5 0.004 17.2 0.0 4.6 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK37408.2 - 2.7e-08 33.0 3.2 0.37 10.6 0.0 5.6 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 EDK37408.2 - 9.8e-08 31.8 1.0 9.1e-05 22.3 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EDK37408.2 - 7e-07 29.0 0.0 0.004 16.9 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 EDK37408.2 - 0.00023 20.7 0.0 1.2 9.0 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 EDK37408.2 - 0.00028 20.9 1.4 0.05 13.7 0.0 2.9 2 2 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EDK37408.2 - 0.00039 19.5 0.2 0.72 8.8 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 EDK37408.2 - 0.02 15.3 2.3 59 4.4 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat IncA PF04156.9 EDK37408.2 - 0.055 13.0 0.1 0.14 11.7 0.1 1.7 1 0 0 1 1 1 0 IncA protein Ring_hydroxyl_A PF00848.14 EDK37409.2 - 4.4e-37 127.7 0.3 7.8e-37 126.9 0.2 1.3 1 0 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.21 EDK37409.2 - 2.7e-16 58.8 0.0 6.5e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain ARID PF01388.16 EDK37410.2 - 2.6e-17 62.4 0.0 2.6e-17 62.4 0.0 2.6 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Glyco_transf_34 PF05637.7 EDK37411.2 - 7e-70 235.2 0.2 9.3e-70 234.8 0.2 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Pex2_Pex12 PF04757.9 EDK37412.2 - 9.9e-20 70.9 0.7 1.3e-19 70.5 0.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 EDK37412.2 - 1.9e-09 37.3 10.1 3.2e-09 36.6 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK37412.2 - 2e-09 37.1 10.0 2.9e-09 36.5 6.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EDK37412.2 - 5.9e-07 29.0 8.6 9.4e-07 28.3 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK37412.2 - 1.5e-06 27.7 10.4 2.3e-06 27.1 7.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK37412.2 - 1.9e-05 24.6 3.7 3.5e-05 23.8 2.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK37412.2 - 3.6e-05 23.4 6.1 5.9e-05 22.7 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 EDK37412.2 - 8.6e-05 22.3 8.8 0.00016 21.4 6.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EDK37412.2 - 0.011 15.4 8.8 0.034 13.8 1.2 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_6 PF14835.1 EDK37412.2 - 0.29 10.9 4.8 0.51 10.1 3.3 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 EDK37412.2 - 0.36 10.7 6.5 0.55 10.1 4.5 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 EDK37412.2 - 1.3 8.6 9.9 2.7 7.6 6.9 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain YdjO PF14169.1 EDK37412.2 - 2.3 7.7 6.4 18 4.8 0.1 2.5 2 0 0 2 2 2 0 Cold-inducible protein YdjO IBR PF01485.16 EDK37412.2 - 3.6 7.5 9.0 19 5.2 6.3 2.0 1 1 0 1 1 1 0 IBR domain IMS PF00817.15 EDK37413.2 - 1.2e-44 151.6 0.0 2e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 EDK37413.2 - 2.6e-05 24.1 0.0 6.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Sulfate_transp PF00916.15 EDK37413.2 - 0.26 10.2 0.0 0.49 9.3 0.0 1.3 1 0 0 1 1 1 0 Sulfate transporter family NAD_binding_6 PF08030.7 EDK37414.2 - 1.9e-13 50.6 0.1 3.2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EDK37414.2 - 2.1e-13 50.4 11.9 2.1e-13 50.4 8.2 3.1 3 1 0 3 3 3 2 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EDK37414.2 - 3.5e-06 26.8 0.1 7.6e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 EDK37414.2 - 0.00073 20.0 0.0 0.0062 17.0 0.0 2.1 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain Ada_Zn_binding PF02805.11 EDK37415.2 - 3.4e-11 42.5 1.6 3.4e-11 42.5 1.1 1.6 2 0 0 2 2 2 1 Metal binding domain of Ada HTH_AraC PF00165.18 EDK37415.2 - 0.0052 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.2 EDK37415.2 - 0.0088 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain NmrA PF05368.8 EDK37416.2 - 5.9e-10 38.7 0.3 7.9e-10 38.3 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EDK37416.2 - 0.032 14.2 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding DUF2454 PF10521.4 EDK37416.2 - 0.09 11.7 0.0 0.25 10.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Pkinase PF00069.20 EDK37417.2 - 2.4e-73 246.4 0.0 3.3e-73 246.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37417.2 - 1.9e-39 135.3 0.0 2.6e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37417.2 - 4.1e-06 25.9 0.0 0.00015 20.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 EDK37417.2 - 0.097 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Aminotran_3 PF00202.16 EDK37418.2 - 1.9e-91 306.4 0.0 2.3e-91 306.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EDK37418.2 - 0.05 12.5 0.0 0.08 11.8 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II DUF2321 PF10083.4 EDK37418.2 - 0.063 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) SRI PF08236.6 EDK37420.2 - 8.4e-31 105.7 3.9 8.4e-31 105.7 2.7 2.5 1 1 1 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 EDK37420.2 - 1.3e-21 77.5 0.1 1.3e-21 77.5 0.1 3.5 2 2 0 2 2 2 1 SET domain WW PF00397.21 EDK37420.2 - 2e-06 27.5 0.2 4e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 WW domain Med26 PF08711.6 EDK37420.2 - 4.4e-05 22.9 6.0 5.8e-05 22.5 2.0 2.7 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Peptidase_S46 PF10459.4 EDK37420.2 - 3.5 5.9 18.9 7 4.9 13.1 1.4 1 0 0 1 1 1 0 Peptidase S46 NAD_Gly3P_dh_N PF01210.18 EDK37421.1 - 6.9e-53 178.5 0.0 1.1e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 EDK37421.1 - 8.5e-46 155.3 0.1 4.2e-45 153.1 0.1 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.12 EDK37421.1 - 0.00035 20.9 0.0 0.36 11.2 0.0 2.6 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.19 EDK37421.1 - 0.0041 17.4 0.0 0.027 14.7 0.0 2.1 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain zf-C2H2 PF00096.21 EDK37422.2 - 8.8e-11 41.4 9.3 2.6e-05 24.2 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37422.2 - 6.8e-10 38.5 3.9 0.00052 20.1 0.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK37422.2 - 2.5e-05 24.2 4.8 0.12 12.5 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 EDK37422.2 - 0.00047 20.3 0.8 0.00047 20.3 0.6 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.2 EDK37422.2 - 0.019 15.1 2.5 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EDK37422.2 - 0.041 13.7 6.5 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger RIG-I_C-RD PF11648.3 EDK37422.2 - 0.094 12.5 2.0 0.29 11.0 1.4 1.8 1 1 0 1 1 1 0 C-terminal domain of RIG-I PHD PF00628.24 EDK37422.2 - 0.16 11.6 0.9 6.9 6.4 0.1 2.3 2 0 0 2 2 2 0 PHD-finger LIM PF00412.17 EDK37422.2 - 0.3 11.1 3.7 0.69 10.0 2.4 1.7 1 1 0 1 1 1 0 LIM domain zf-H2C2_5 PF13909.1 EDK37422.2 - 7.1 7.0 7.4 3.7 7.9 2.1 2.5 2 1 0 2 2 2 0 C2H2-type zinc-finger domain ING PF12998.2 EDK37423.2 - 3.4e-23 81.9 0.0 7.4e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EDK37423.2 - 9.3e-09 34.8 7.1 1.8e-08 33.9 4.9 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 EDK37423.2 - 0.038 13.3 1.9 0.071 12.4 1.3 1.5 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.1 EDK37423.2 - 0.059 13.5 0.5 0.14 12.3 0.4 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain CDC45 PF02724.9 EDK37423.2 - 0.65 7.9 4.1 0.82 7.6 2.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF566 PF04484.7 EDK37423.2 - 2.5 7.5 8.4 4.7 6.6 5.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) Ras PF00071.17 EDK37424.2 - 3.1e-45 153.4 0.1 3.7e-45 153.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK37424.2 - 3.6e-21 75.8 0.0 4.4e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK37424.2 - 3.4e-10 39.4 0.0 3.9e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK37424.2 - 2e-06 27.3 0.0 1.1e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK37424.2 - 1.1e-05 25.3 0.0 1.3e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 EDK37424.2 - 0.0037 16.4 0.0 0.005 16.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_25 PF13481.1 EDK37424.2 - 0.011 15.1 0.1 0.044 13.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 EDK37424.2 - 0.052 12.5 0.0 0.085 11.8 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF258 PF03193.11 EDK37424.2 - 0.056 12.6 0.4 0.13 11.4 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EDK37424.2 - 0.058 13.5 0.0 0.16 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 EDK37424.2 - 0.13 11.6 0.1 0.92 8.8 0.0 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DAD PF02109.11 EDK37425.1 - 5.5e-39 132.7 3.1 2.8e-38 130.4 2.1 1.8 1 1 0 1 1 1 1 DAD family YGGT PF02325.12 EDK37425.1 - 0.032 14.1 0.3 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 YGGT family Y_phosphatase2 PF03162.8 EDK37427.2 - 1.4e-49 167.6 0.0 1.6e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EDK37427.2 - 3.6e-07 30.5 0.0 2.8e-05 24.4 0.0 2.1 1 1 1 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.15 EDK37427.2 - 0.0019 17.7 0.0 0.0027 17.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain IclR PF01614.13 EDK37428.2 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional regulator SPC25 PF06703.6 EDK37428.2 - 0.075 12.6 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) GSHPx PF00255.14 EDK37429.2 - 2.7e-47 158.6 0.4 3.6e-47 158.2 0.3 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.5 EDK37429.2 - 1.4e-06 27.9 0.1 4.7e-06 26.1 0.0 1.8 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EDK37429.2 - 1.4e-06 27.9 0.2 2.9e-06 26.9 0.1 1.5 1 1 0 1 1 1 1 AhpC/TSA family SCO1-SenC PF02630.9 EDK37429.2 - 0.0079 15.8 0.1 0.57 9.7 0.0 2.7 2 1 1 3 3 3 1 SCO1/SenC DUF4174 PF13778.1 EDK37429.2 - 0.061 13.4 0.0 0.12 12.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4174) Pkinase PF00069.20 EDK37430.2 - 4.9e-52 176.6 0.1 6.6e-52 176.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37430.2 - 9e-29 100.3 0.0 1.3e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37430.2 - 0.00055 18.9 0.0 0.0081 15.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK37430.2 - 0.0072 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family IlvN PF07991.7 EDK37431.2 - 1.6e-44 151.1 0.0 2.4e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 EDK37431.2 - 9.8e-17 61.2 0.1 2e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain GRAM PF02893.15 EDK37432.2 - 9.2e-18 63.5 0.0 2e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Baculo_11_kDa PF06143.6 EDK37432.2 - 0.001 18.4 0.9 0.0025 17.1 0.6 1.6 1 0 0 1 1 1 1 Baculovirus 11 kDa family 6PF2K PF01591.13 EDK37434.2 - 1.1e-76 256.8 0.0 2.7e-76 255.5 0.0 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EDK37434.2 - 3.8e-25 88.8 0.1 8.9e-25 87.6 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EDK37434.2 - 0.00012 21.9 0.0 0.00043 20.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK37434.2 - 0.013 16.3 0.0 0.078 13.8 0.0 2.4 1 1 0 1 1 1 0 AAA domain Vac7 PF12751.2 EDK37435.2 - 4.1e-32 111.5 3.5 5.7e-18 64.9 0.0 3.2 2 1 0 3 3 3 2 Vacuolar segregation subunit 7 p450 PF00067.17 EDK37436.2 - 8.2e-48 163.0 0.2 1.9e-47 161.8 0.1 1.5 1 1 0 1 1 1 1 Cytochrome P450 bZIP_1 PF00170.16 EDK37436.2 - 1.1 9.2 5.1 0.18 11.7 0.4 1.9 2 0 0 2 2 2 0 bZIP transcription factor muHD PF10291.4 EDK37437.2 - 3.1e-63 213.3 0.2 5.8e-63 212.4 0.1 1.5 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Ammonium_transp PF00909.16 EDK37438.2 - 8.8e-122 406.4 28.4 1e-121 406.2 19.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family UPF0183 PF03676.9 EDK37439.2 - 2.4e-30 105.4 1.9 1.6e-28 99.3 1.3 2.8 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0183) LRR_9 PF14580.1 EDK37440.2 - 1.5e-33 115.8 0.4 2.1e-33 115.3 0.3 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 EDK37440.2 - 6.3e-08 32.0 2.6 0.0015 18.0 0.2 3.5 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK37440.2 - 2.1e-05 24.1 1.2 0.07 12.8 0.0 2.9 1 1 2 3 3 3 2 Leucine rich repeat DUF515 PF04415.7 EDK37440.2 - 0.024 12.8 0.1 0.035 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) LRR_1 PF00560.28 EDK37440.2 - 0.57 10.4 3.8 31 5.1 0.0 4.2 3 2 1 4 4 4 0 Leucine Rich Repeat BAH PF01426.13 EDK37441.2 - 6.1e-14 51.7 0.0 1.8e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 BAH domain PHD PF00628.24 EDK37441.2 - 2.8e-09 36.5 28.7 3.3e-07 29.9 8.5 6.7 6 0 0 6 6 6 3 PHD-finger zf-HC5HC2H PF13771.1 EDK37441.2 - 0.00016 21.7 1.6 0.00016 21.7 1.1 5.8 3 2 1 5 5 5 1 PHD-like zinc-binding domain PHD_2 PF13831.1 EDK37441.2 - 0.0002 20.5 1.1 0.0002 20.5 0.8 6.1 6 0 0 6 6 6 2 PHD-finger mRNA_cap_enzyme PF01331.14 EDK37442.2 - 9.7e-63 211.3 0.1 1.4e-62 210.8 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 EDK37442.2 - 1.5e-25 89.5 0.3 3e-25 88.5 0.2 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 EDK37442.2 - 1.1e-06 28.2 0.0 4.3e-05 22.9 0.0 2.3 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DUF4420 PF14390.1 EDK37442.2 - 0.058 12.2 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4420) FMO-like PF00743.14 EDK37443.2 - 5.7e-32 110.6 0.2 3.3e-13 48.6 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EDK37443.2 - 5.6e-12 46.1 0.0 2.8e-11 43.8 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK37443.2 - 2.7e-09 36.4 0.9 0.00011 21.2 0.1 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EDK37443.2 - 5.5e-07 29.6 0.0 2.3e-05 24.3 0.0 2.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK37443.2 - 7.8e-07 28.9 0.6 1.7e-05 24.6 0.1 3.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EDK37443.2 - 2.7e-05 24.1 0.0 7.4e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.18 EDK37443.2 - 0.019 14.6 0.1 0.43 10.2 0.0 2.3 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox PF00070.22 EDK37443.2 - 0.023 15.0 0.0 0.25 11.7 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 EDK37443.2 - 0.066 13.3 0.1 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.12 EDK37443.2 - 0.072 12.1 0.1 0.31 10.0 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Prefoldin_2 PF01920.15 EDK37444.1 - 1.8e-16 59.7 11.1 2.2e-16 59.5 7.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit PhoU PF01895.14 EDK37444.1 - 0.035 14.5 1.7 0.035 14.5 1.2 2.2 1 1 1 2 2 2 0 PhoU domain DUF4094 PF13334.1 EDK37444.1 - 0.036 14.4 0.9 0.036 14.4 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) FliD_C PF07195.7 EDK37444.1 - 0.045 13.0 4.2 0.12 11.6 2.8 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Sec2p PF06428.6 EDK37444.1 - 0.057 13.2 0.4 0.057 13.2 0.3 1.9 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p GP41 PF00517.12 EDK37444.1 - 0.085 12.4 1.1 0.14 11.6 0.0 1.7 2 0 0 2 2 2 0 Retroviral envelope protein SlyX PF04102.7 EDK37444.1 - 0.093 13.1 1.0 0.093 13.1 0.7 1.9 2 1 0 2 2 2 0 SlyX TraF_2 PF13729.1 EDK37444.1 - 0.23 10.2 3.6 1.6 7.4 0.4 2.0 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein Sec20 PF03908.8 EDK37444.1 - 0.23 11.1 2.3 0.26 11.0 0.3 1.9 2 0 0 2 2 2 0 Sec20 Cob_adeno_trans PF01923.13 EDK37444.1 - 0.24 11.1 2.2 0.35 10.6 1.5 1.5 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DUF724 PF05266.9 EDK37444.1 - 0.26 10.9 6.4 0.35 10.4 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc24 PF08286.6 EDK37444.1 - 0.33 10.6 8.6 0.53 9.9 1.0 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Lge1 PF11488.3 EDK37444.1 - 0.54 10.4 3.8 0.27 11.4 0.4 2.0 1 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF972 PF06156.8 EDK37444.1 - 0.86 9.9 4.1 0.55 10.6 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) AATF-Che1 PF13339.1 EDK37444.1 - 1.7 8.8 6.0 0.95 9.6 0.9 2.0 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor NPV_P10 PF05531.7 EDK37444.1 - 1.9 8.7 4.8 18 5.6 0.5 2.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.6 EDK37444.1 - 2 8.8 7.5 0.74 10.2 0.9 2.2 1 1 0 2 2 2 0 Syntaxin 6, N-terminal Prefoldin PF02996.12 EDK37444.1 - 3 7.5 10.7 63 3.2 7.4 2.2 1 1 0 1 1 1 0 Prefoldin subunit Tropomyosin_1 PF12718.2 EDK37444.1 - 3.6 7.4 13.6 0.69 9.7 5.7 2.0 1 1 1 2 2 2 0 Tropomyosin like DivIC PF04977.10 EDK37444.1 - 4.1 6.9 9.7 3.7 7.1 0.7 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF848 PF05852.6 EDK37444.1 - 4.7 7.0 7.8 6.2 6.6 0.6 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Snf7 PF03357.16 EDK37444.1 - 5.7 6.2 11.2 0.74 9.1 1.4 2.1 2 0 0 2 2 2 0 Snf7 Rho_Binding PF08912.6 EDK37444.1 - 9 6.6 8.6 7 7.0 1.9 2.6 2 1 1 3 3 3 0 Rho Binding Acetyltransf_9 PF13527.1 EDK37445.2 - 8.2e-07 28.9 0.0 7.2e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK37445.2 - 1.3e-06 28.4 0.0 8e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EDK37445.2 - 1.4e-06 28.1 0.0 7.8e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Flavodoxin_5 PF12724.2 EDK37445.2 - 0.011 15.7 0.3 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 Flavodoxin domain Acetyltransf_10 PF13673.1 EDK37445.2 - 0.02 15.0 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK37445.2 - 0.021 14.6 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.5 EDK37445.2 - 0.08 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Glutaredoxin PF00462.19 EDK37446.1 - 5.5e-18 64.7 0.0 7.6e-18 64.2 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 EDK37446.1 - 8e-05 22.2 0.0 9.4e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF836 PF05768.9 EDK37446.1 - 0.00034 20.8 0.0 0.00042 20.5 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) DSBA PF01323.15 EDK37446.1 - 0.0014 18.2 0.2 0.15 11.5 0.1 2.1 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.1 EDK37446.1 - 0.0028 17.4 0.2 0.0046 16.7 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.1 EDK37446.1 - 0.0045 17.1 0.1 0.007 16.5 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 EDK37446.1 - 0.0075 15.8 0.0 0.0086 15.6 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_4 PF13462.1 EDK37446.1 - 0.021 14.8 0.7 1.1 9.2 0.1 2.1 1 1 0 2 2 2 0 Thioredoxin Homeobox_KN PF05920.6 EDK37448.2 - 7.8e-09 35.1 4.0 2.9e-08 33.2 2.8 2.0 1 1 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 EDK37448.2 - 0.017 14.7 3.0 0.027 14.0 2.1 1.3 1 0 0 1 1 1 0 Homeobox domain Exo70 PF03081.10 EDK37449.2 - 1.9e-92 309.9 9.7 1.9e-92 309.9 6.7 2.0 2 0 0 2 2 2 2 Exo70 exocyst complex subunit tRNA_lig_kinase PF08303.6 EDK37450.2 - 5.7e-65 218.2 0.1 6.8e-64 214.7 0.1 2.4 3 0 0 3 3 3 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 EDK37450.2 - 2.9e-61 206.9 0.2 4.1e-61 206.4 0.1 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.5 EDK37450.2 - 8.5e-41 139.8 0.4 2.8e-40 138.1 0.1 2.0 2 0 0 2 2 2 1 RNA ligase ABC_tran PF00005.22 EDK37450.2 - 0.0023 18.2 0.1 0.021 15.0 0.1 2.4 2 1 0 2 2 2 1 ABC transporter DUF673 PF05054.7 EDK37450.2 - 0.015 13.9 0.0 0.03 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF673) BRCA2 PF00634.13 EDK37450.2 - 0.2 10.9 1.7 2.6 7.3 0.3 2.5 2 0 0 2 2 2 0 BRCA2 repeat HhH-GPD PF00730.20 EDK37451.2 - 2.2e-13 50.4 0.0 4.1e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NYD-SP28_assoc PF14775.1 EDK37451.2 - 0.23 11.1 2.6 0.23 11.1 0.7 1.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain TBD PF12845.2 EDK37452.2 - 0.045 13.3 0.1 0.16 11.5 0.1 1.9 2 0 0 2 2 2 0 TBD domain Pox_A_type_inc PF04508.7 EDK37452.2 - 0.1 12.4 2.1 0.68 9.8 0.8 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Transthyretin PF00576.16 EDK37454.2 - 1.1e-19 70.4 0.2 8.9e-17 60.9 0.1 2.3 1 1 0 1 1 1 1 HIUase/Transthyretin family Stn1 PF10451.4 EDK37455.2 - 1.2e-15 57.0 0.1 1.9e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Methyltransf_8 PF05148.10 EDK37456.2 - 1.6e-62 211.0 1.2 6.4e-61 205.7 0.1 2.8 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 EDK37456.2 - 2.1e-08 34.5 0.3 1.2e-07 32.1 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK37456.2 - 2.6e-05 23.8 0.1 5.5e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 EDK37456.2 - 0.0032 17.1 0.5 0.022 14.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK37456.2 - 0.024 14.9 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF3405 PF11885.3 EDK37456.2 - 3.5 5.7 7.1 5.4 5.1 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) WD40 PF00400.27 EDK37457.2 - 9.3e-06 25.3 2.6 0.072 12.9 0.0 4.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Ets PF00178.17 EDK37457.2 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Ets-domain HECT PF00632.20 EDK37458.2 - 3e-92 309.1 0.0 4.2e-92 308.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 EDK37458.2 - 3.5e-33 113.0 20.1 5.6e-11 42.0 1.6 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.25 EDK37458.2 - 8e-18 64.0 0.8 1.8e-17 62.9 0.6 1.6 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.20 EDK37460.2 - 5.7e-33 114.1 0.0 7.2e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37460.2 - 1.8e-11 43.6 0.0 2.4e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK37460.2 - 0.0028 17.4 0.0 0.13 11.9 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EDK37460.2 - 0.13 11.5 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL MRG PF05712.8 EDK37461.2 - 2.8e-49 166.6 0.2 4.6e-49 165.9 0.1 1.3 1 1 0 1 1 1 1 MRG Tudor-knot PF11717.3 EDK37461.2 - 6.5e-12 44.9 1.0 1.3e-11 44.0 0.7 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain CD24 PF14984.1 EDK37461.2 - 0.0086 15.8 1.5 0.022 14.5 1.0 1.7 1 0 0 1 1 1 1 CD24 protein DUF2578 PF10843.3 EDK37462.1 - 3.7e-99 330.1 5.2 4.2e-99 330.0 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2578) CaMKII_AD PF08332.5 EDK37462.1 - 0.096 12.5 0.2 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association Tim17 PF02466.14 EDK37463.2 - 5.7e-47 158.9 6.9 5.7e-47 158.9 4.8 1.7 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DLH PF01738.13 EDK37463.2 - 0.0031 16.8 1.1 0.0073 15.6 0.2 1.8 1 1 1 2 2 2 1 Dienelactone hydrolase family Chromate_transp PF02417.10 EDK37463.2 - 0.025 14.1 1.0 0.055 13.0 0.7 1.6 1 0 0 1 1 1 0 Chromate transporter Bacteriocin_IIc PF10439.4 EDK37463.2 - 4.3 7.5 7.3 18 5.5 1.7 2.4 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide GP41 PF00517.12 EDK37464.2 - 0.012 15.2 0.1 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 Retroviral envelope protein CCD PF07860.6 EDK37464.2 - 0.11 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 WisP family C-Terminal Region IDH PF03971.9 EDK37464.2 - 0.13 10.6 0.1 0.16 10.3 0.1 1.1 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase Chitin_synth_1 PF01644.12 EDK37465.2 - 9e-78 259.7 0.1 1.4e-77 259.0 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 EDK37465.2 - 3.9e-25 87.3 0.0 1e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 EDK37465.2 - 5.1e-25 87.8 4.6 1e-17 63.7 0.0 3.3 3 1 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EDK37465.2 - 1.3e-10 41.3 0.7 1.3e-10 41.3 0.5 2.9 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EDK37465.2 - 2.9e-06 27.2 0.0 8.7e-05 22.4 0.0 2.6 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EDK37465.2 - 0.0083 15.8 0.0 0.9 9.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 A_deaminase PF00962.17 EDK37466.1 - 8.6e-79 264.8 0.0 9.7e-79 264.6 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Atg8 PF02991.11 EDK37467.1 - 1e-45 153.9 0.0 1.2e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 EDK37467.1 - 1.8e-05 24.8 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 GatB_N PF02934.10 EDK37468.2 - 6.6e-99 330.4 0.0 8.9e-99 329.9 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 EDK37468.2 - 2.2e-25 89.1 0.1 4.4e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 GatB domain STE3 PF02076.10 EDK37469.2 - 2.9e-86 289.0 19.2 3.4e-86 288.8 13.3 1.0 1 0 0 1 1 1 1 Pheromone A receptor YwiC PF14256.1 EDK37469.2 - 0.0095 16.0 1.1 0.0095 16.0 0.7 2.2 2 0 0 2 2 2 1 YwiC-like protein CitMHS PF03600.11 EDK37469.2 - 4.8 5.6 10.6 0.049 12.1 2.0 1.6 2 0 0 2 2 2 0 Citrate transporter Syndecan PF01034.15 EDK37469.2 - 6.7 6.4 8.0 42 3.8 0.1 3.8 4 0 0 4 4 4 0 Syndecan domain HEAT_EZ PF13513.1 EDK37470.2 - 6e-15 55.2 6.1 0.093 13.2 0.0 10.7 9 1 3 12 12 11 3 HEAT-like repeat HEAT PF02985.17 EDK37470.2 - 5.4e-12 44.7 4.1 0.00082 19.2 0.0 9.4 12 0 0 12 12 10 2 HEAT repeat HEAT_2 PF13646.1 EDK37470.2 - 5.7e-11 42.5 13.3 0.0011 19.2 0.1 7.6 5 3 5 10 10 10 4 HEAT repeats Vac14_Fab1_bd PF12755.2 EDK37470.2 - 4.9e-08 33.2 0.8 1.3 9.4 0.0 6.8 6 1 1 7 7 7 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 EDK37470.2 - 1.1e-07 31.6 1.6 2.1e-06 27.5 0.3 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ipi1_N PF12333.3 EDK37470.2 - 3.5e-07 30.1 1.8 0.76 9.7 0.0 5.5 5 0 0 5 5 5 2 Rix1 complex component involved in 60S ribosome maturation ParcG PF10274.4 EDK37470.2 - 3.9e-07 30.1 0.3 0.086 12.7 0.1 4.2 3 1 1 4 4 4 2 Parkin co-regulated protein RIX1 PF08167.7 EDK37470.2 - 1.6e-06 27.8 0.5 3.3 7.3 0.0 5.5 4 1 1 5 5 5 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.2 EDK37470.2 - 2.2e-05 24.4 4.1 0.77 9.5 0.0 5.0 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 EDK37470.2 - 3.4e-05 23.2 3.9 0.2 10.9 0.0 4.7 5 1 0 5 5 5 2 CLASP N terminal MMS19_C PF12460.3 EDK37470.2 - 0.0012 17.6 11.4 0.66 8.6 0.1 4.9 3 2 1 4 4 4 2 RNAPII transcription regulator C-terminal DEAD PF00270.24 EDK37471.2 - 1e-42 145.5 1.7 5.3e-42 143.1 0.8 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK37471.2 - 5.2e-28 96.7 0.1 1.3e-27 95.4 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 EDK37471.2 - 0.00028 20.5 0.2 0.00097 18.8 0.0 1.9 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 EDK37471.2 - 0.0015 18.1 0.2 0.014 14.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain SNF2_N PF00176.18 EDK37471.2 - 0.0027 16.5 0.0 0.0045 15.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 EDK37471.2 - 0.0038 17.0 0.1 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 EDK37471.2 - 0.0043 16.7 0.0 0.008 15.8 0.0 1.5 1 0 0 1 1 1 1 Helicase Helicase_C_2 PF13307.1 EDK37471.2 - 0.019 14.9 0.0 0.091 12.7 0.0 2.0 1 1 1 2 2 2 0 Helicase C-terminal domain DUF2075 PF09848.4 EDK37471.2 - 0.033 13.1 0.0 0.054 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 EDK37471.2 - 0.11 12.1 0.4 0.17 11.4 0.3 1.7 1 1 0 1 1 1 0 AAA domain PRK PF00485.13 EDK37472.1 - 4.4e-16 59.0 0.5 1.7e-14 53.8 0.3 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 EDK37472.1 - 4.1e-05 23.8 0.1 0.00025 21.3 0.0 2.1 1 1 1 2 2 2 1 AAA domain CPT PF07931.7 EDK37472.1 - 0.0022 17.6 0.1 0.0046 16.5 0.0 1.6 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.1 EDK37472.1 - 0.022 15.5 0.0 0.046 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain CoaE PF01121.15 EDK37472.1 - 0.025 13.9 0.1 0.18 11.2 0.1 2.1 1 1 0 1 1 1 0 Dephospho-CoA kinase DUF4221 PF13970.1 EDK37472.1 - 0.031 13.5 0.2 0.038 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) Nucleoporin_C PF03177.9 EDK37474.2 - 2.7e-122 409.2 15.0 4.1e-122 408.6 10.4 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EDK37474.2 - 2.9e-112 375.5 9.9 4.3e-112 374.9 6.8 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Peptidase_M28 PF04389.12 EDK37475.2 - 1.2e-25 90.3 0.3 3.1e-25 88.9 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 EDK37475.2 - 0.0026 17.3 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 SSB PF00436.20 EDK37476.2 - 1.1e-17 63.8 0.0 1.3e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family SecY PF00344.15 EDK37478.1 - 1.9e-72 244.0 18.7 2.2e-72 243.8 13.0 1.0 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 EDK37478.1 - 0.0011 18.4 0.0 0.0034 16.8 0.0 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p DUF846 PF05832.7 EDK37478.1 - 7.9 6.1 10.4 0.86 9.2 3.1 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF846) Ras PF00071.17 EDK37479.1 - 8.1e-48 161.8 0.1 9.6e-48 161.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.16 EDK37479.1 - 3.4e-18 65.4 0.0 4.5e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 EDK37479.1 - 3.5e-16 59.7 0.0 6.1e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 EDK37479.1 - 3.2e-07 29.7 0.1 4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EDK37479.1 - 9.4e-07 28.7 0.0 1.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK37479.1 - 1.5e-06 27.7 0.1 1.3e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 EDK37479.1 - 0.0005 19.3 0.0 0.00085 18.5 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EDK37479.1 - 0.00054 19.4 0.0 0.36 10.2 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 EDK37479.1 - 0.0011 18.2 0.4 0.092 12.0 0.3 2.4 1 1 0 1 1 1 1 Ferrous iron transport protein B DNA_pol3_delta2 PF13177.1 EDK37479.1 - 0.027 14.1 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_24 PF13479.1 EDK37479.1 - 0.061 12.9 0.5 1.4 8.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF258 PF03193.11 EDK37479.1 - 0.067 12.3 0.0 0.34 10.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK37479.1 - 0.068 13.1 0.1 0.16 11.9 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF905 PF06006.7 EDK37479.1 - 0.099 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) DHHA2 PF02833.9 EDK37479.1 - 0.11 12.6 0.1 0.26 11.4 0.0 1.5 1 1 0 1 1 1 0 DHHA2 domain PAP_assoc PF03828.14 EDK37480.2 - 7.2e-15 54.6 0.1 2e-14 53.2 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 EDK37480.2 - 6.4e-14 52.0 3.5 3.6e-13 49.6 0.1 2.6 2 0 0 2 2 2 1 Nucleotidyltransferase domain TRAUB PF08164.7 EDK37480.2 - 0.045 13.8 0.6 0.045 13.8 0.4 2.5 3 0 0 3 3 3 0 Apoptosis-antagonizing transcription factor, C-terminal Pkinase PF00069.20 EDK37481.2 - 2.6e-30 105.4 0.0 2.9e-29 102.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37481.2 - 4.2e-15 55.5 0.0 1e-12 47.7 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Bcl-2 PF00452.14 EDK37481.2 - 0.081 13.0 0.0 4.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Rif1_N PF12231.3 EDK37483.2 - 5.4e-06 25.6 0.0 1.6e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Rif1_N PF12231.3 EDK37484.1 - 5.7e-07 28.8 0.2 9.3e-07 28.1 0.1 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal RF-1 PF00472.15 EDK37486.1 - 2.3e-14 53.1 0.1 3.4e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 RF-1 domain Spt20 PF12090.3 EDK37487.2 - 1.2e-54 184.4 0.4 1.2e-54 184.4 0.3 4.8 2 1 1 3 3 3 1 Spt20 family FHA PF00498.21 EDK37488.2 - 4.6e-14 52.2 0.0 1.1e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 FHA domain Sdh5 PF03937.11 EDK37488.2 - 0.12 12.0 0.1 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase Transposase_24 PF03004.9 EDK37488.2 - 0.79 9.6 7.8 0.092 12.6 2.0 2.0 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) PhyH PF05721.8 EDK37489.2 - 1.3e-45 156.0 0.0 1.6e-45 155.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.1 EDK37489.2 - 0.026 14.8 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Transp_cyt_pur PF02133.10 EDK37490.2 - 1.1e-16 60.5 42.5 3.5e-16 58.7 29.4 1.7 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TENA_THI-4 PF03070.11 EDK37491.2 - 1.4e-15 57.6 1.0 1.8e-15 57.2 0.7 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family SCO1-SenC PF02630.9 EDK37492.2 - 2.7e-62 209.4 0.0 3.8e-62 208.9 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 EDK37492.2 - 0.0023 17.6 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family SET PF00856.23 EDK37493.2 - 6.7e-05 23.2 0.0 0.00017 21.9 0.0 1.6 1 0 0 1 1 1 1 SET domain Pho88 PF10032.4 EDK37494.1 - 5.1e-85 283.5 0.9 5.6e-85 283.4 0.6 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) PAPS_reduct PF01507.14 EDK37494.1 - 0.022 14.5 0.1 0.1 12.4 0.0 1.8 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family SNase PF00565.12 EDK37495.2 - 8.6e-35 119.2 0.0 2.4e-10 40.6 0.0 5.5 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.19 EDK37495.2 - 1.1e-13 51.0 0.0 2.4e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Tudor domain LBR_tudor PF09465.5 EDK37495.2 - 0.089 12.4 0.7 0.3 10.7 0.1 2.2 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain UQ_con PF00179.21 EDK37496.1 - 6.5e-49 164.9 0.0 7.3e-49 164.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Amino_oxidase PF01593.19 EDK37497.2 - 3.7e-61 207.5 0.0 5.5e-60 203.7 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 EDK37497.2 - 1.1e-12 47.7 0.0 2.6e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EDK37497.2 - 1.8e-06 27.8 0.1 0.00069 19.4 0.0 2.6 2 1 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.19 EDK37497.2 - 6.6e-06 25.2 0.0 0.0027 16.6 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EDK37497.2 - 5.2e-05 23.4 0.1 0.0016 18.5 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK37497.2 - 0.012 16.0 0.3 0.088 13.2 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EDK37497.2 - 0.014 14.5 0.1 0.021 13.9 0.1 1.2 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 EDK37497.2 - 0.023 13.2 0.1 0.75 8.1 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Polysacc_synt_4 PF04669.8 EDK37498.1 - 1.3e-23 83.3 1.0 8.5e-23 80.7 0.7 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis Striatin PF08232.7 EDK37499.2 - 1.2e-26 93.5 0.8 1.2e-26 93.5 0.5 3.3 2 1 0 2 2 2 1 Striatin family WD40_alt PF14077.1 EDK37499.2 - 0.029 14.0 0.3 3.4 7.3 0.0 2.7 1 1 1 2 2 2 0 Alternative WD40 repeat motif ABC_tran PF00005.22 EDK37500.2 - 3.5e-48 163.3 2.3 4e-27 95.1 0.0 4.7 4 3 1 5 5 2 2 ABC transporter AAA_21 PF13304.1 EDK37500.2 - 7.1e-15 55.7 2.7 0.00047 20.2 0.1 4.8 4 1 0 4 4 3 3 AAA domain Chromo PF00385.19 EDK37500.2 - 8.5e-10 38.1 1.4 2.5e-09 36.6 0.9 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SMC_N PF02463.14 EDK37500.2 - 9.7e-10 38.0 0.0 0.014 14.6 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK37500.2 - 5.7e-08 32.1 0.3 0.016 14.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 EDK37500.2 - 4.2e-07 29.3 0.1 0.1 11.6 0.0 3.8 4 0 0 4 4 3 2 AAA ATPase domain Miro PF08477.8 EDK37500.2 - 1.1e-06 29.1 0.0 0.014 15.9 0.0 3.0 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 EDK37500.2 - 1.4e-06 29.0 0.0 0.11 13.3 0.0 3.2 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 EDK37500.2 - 2.1e-06 27.0 0.0 0.012 14.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EDK37500.2 - 2.3e-06 27.5 0.0 0.021 14.7 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.1 EDK37500.2 - 3.6e-06 27.4 11.8 0.018 15.3 0.5 3.8 3 1 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EDK37500.2 - 1.5e-05 25.1 0.0 0.06 13.4 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 EDK37500.2 - 2.5e-05 24.2 0.0 0.12 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EDK37500.2 - 2.7e-05 23.7 1.0 0.36 10.2 0.0 3.7 4 0 0 4 4 4 2 AAA-like domain ArgK PF03308.11 EDK37500.2 - 0.0006 18.6 0.1 0.46 9.2 0.0 2.5 2 0 0 2 2 2 2 ArgK protein AAA_33 PF13671.1 EDK37500.2 - 0.00071 19.4 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EDK37500.2 - 0.001 19.3 1.0 0.38 11.0 0.0 3.3 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.17 EDK37500.2 - 0.0013 18.9 0.0 2.3 8.4 0.0 2.9 2 0 0 2 2 2 1 RNA helicase SbcCD_C PF13558.1 EDK37500.2 - 0.0014 18.5 0.2 3.9 7.4 0.0 3.9 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 EDK37500.2 - 0.0015 17.1 1.3 1.1 7.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.7 EDK37500.2 - 0.0029 17.2 0.3 1.8 8.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain MobB PF03205.9 EDK37500.2 - 0.0033 17.1 0.0 1.4 8.5 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.18 EDK37500.2 - 0.0042 16.9 3.0 0.27 11.0 0.0 3.7 4 0 0 4 4 3 1 Dynamin family Zeta_toxin PF06414.7 EDK37500.2 - 0.0062 15.6 0.8 3.6 6.6 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin AAA PF00004.24 EDK37500.2 - 0.0064 16.6 0.0 7 6.8 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.12 EDK37500.2 - 0.0065 16.3 5.8 0.093 12.5 0.0 3.6 4 0 0 4 4 3 1 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 EDK37500.2 - 0.0065 15.9 0.0 2.8 7.3 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_25 PF13481.1 EDK37500.2 - 0.0076 15.6 0.0 4.4 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 EDK37500.2 - 0.01 15.4 0.1 4.8 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain LAT PF15234.1 EDK37500.2 - 0.014 14.8 0.8 0.014 14.8 0.5 1.7 2 0 0 2 2 1 0 Linker for activation of T-cells AAA_14 PF13173.1 EDK37500.2 - 0.024 14.5 0.0 4.3 7.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EDK37500.2 - 0.041 13.3 0.4 6.4 6.2 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 EDK37500.2 - 0.042 13.2 0.1 17 4.8 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF815 PF05673.8 EDK37500.2 - 0.046 12.6 0.4 4.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MutS_V PF00488.16 EDK37500.2 - 0.047 13.0 0.1 11 5.3 0.0 2.3 2 0 0 2 2 2 0 MutS domain V AAA_16 PF13191.1 EDK37500.2 - 0.074 13.0 1.9 2.5 8.0 0.0 3.2 3 1 0 3 3 3 0 AAA ATPase domain Proteasome PF00227.21 EDK37501.2 - 1.3e-43 148.4 0.0 1.6e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Utp14 PF04615.8 EDK37502.2 - 2.1e-207 690.7 74.7 2.1e-207 690.7 51.8 2.0 1 1 1 2 2 2 1 Utp14 protein ALO PF04030.9 EDK37503.1 - 3.2e-98 328.4 0.4 5.3e-98 327.7 0.1 1.5 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 EDK37503.1 - 1.3e-22 79.8 0.0 3.5e-22 78.3 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain SIS_2 PF13580.1 EDK37503.1 - 0.099 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 SIS domain PEX11 PF05648.9 EDK37504.2 - 0.00059 19.1 0.3 0.00092 18.5 0.2 1.3 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Cas_Csy2 PF09614.5 EDK37504.2 - 0.02 14.1 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy2) Dsl1_C PF11989.3 EDK37505.2 - 5.2e-13 48.8 14.0 5.2e-13 48.8 9.7 2.1 2 1 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal DUF92 PF01940.11 EDK37505.2 - 0.21 10.7 0.3 0.33 10.0 0.2 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 HMA PF00403.21 EDK37506.1 - 5.2e-13 48.9 0.2 6.2e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF211 PF02680.9 EDK37506.1 - 0.01 15.6 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 DUF4097 PF13349.1 EDK37506.1 - 0.012 15.1 0.4 0.013 15.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) ABC_membrane PF00664.18 EDK37507.2 - 1.9e-50 171.8 39.0 1.9e-28 99.6 9.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK37507.2 - 4.9e-50 169.3 0.4 1.3e-29 103.2 0.0 3.3 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EDK37507.2 - 2.2e-09 37.7 10.2 1.8e-06 28.1 0.3 4.7 3 2 1 4 4 4 2 AAA domain SMC_N PF02463.14 EDK37507.2 - 4.1e-09 36.0 9.2 0.00019 20.7 0.1 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK37507.2 - 6.6e-09 35.1 0.4 0.00028 20.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EDK37507.2 - 3.5e-06 26.2 0.6 0.04 13.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_23 PF13476.1 EDK37507.2 - 3.6e-05 24.1 12.7 0.11 12.8 0.0 3.4 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 EDK37507.2 - 3.7e-05 24.2 0.3 0.25 11.8 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 EDK37507.2 - 0.00012 22.9 0.1 0.079 13.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK37507.2 - 0.00022 21.2 1.0 0.28 11.1 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 EDK37507.2 - 0.00023 21.1 4.2 0.023 14.6 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase T2SE PF00437.15 EDK37507.2 - 0.00051 19.0 0.0 0.037 12.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.1 EDK37507.2 - 0.0013 18.3 0.1 0.92 9.0 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 EDK37507.2 - 0.0013 18.8 2.8 2.8 8.1 0.3 3.4 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 EDK37507.2 - 0.0016 18.3 1.5 1.2 8.8 0.0 2.6 2 0 0 2 2 2 2 Dynamin family AAA_18 PF13238.1 EDK37507.2 - 0.0028 17.9 1.2 0.79 10.0 0.1 3.2 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EDK37507.2 - 0.0028 17.1 0.2 0.86 9.0 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EDK37507.2 - 0.0048 16.3 0.3 1.5 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain Zeta_toxin PF06414.7 EDK37507.2 - 0.0071 15.4 0.1 1.3 8.1 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin ATP_bind_1 PF03029.12 EDK37507.2 - 0.016 14.7 1.1 0.78 9.2 0.2 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein ArgK PF03308.11 EDK37507.2 - 0.029 13.1 0.1 0.73 8.5 0.0 2.3 2 0 0 2 2 2 0 ArgK protein Arch_ATPase PF01637.13 EDK37507.2 - 0.032 13.9 1.8 2.5 7.7 0.0 3.4 3 0 0 3 3 3 0 Archaeal ATPase ATP-synt_ab PF00006.20 EDK37507.2 - 0.038 13.5 0.1 4.5 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 EDK37507.2 - 0.055 12.8 0.2 1.2 8.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain DUF585 PF04522.7 EDK37507.2 - 0.064 12.6 0.9 0.12 11.7 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF585) Halogen_Hydrol PF10112.4 EDK37507.2 - 3.2 7.0 6.1 0.28 10.5 0.4 2.0 2 0 0 2 2 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein WD40 PF00400.27 EDK37510.2 - 4.1e-10 39.1 6.3 1.3e-05 24.8 0.2 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat T4_baseplate PF12322.3 EDK37510.2 - 0.044 13.0 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 T4 bacteriophage base plate protein Yae1_N PF09811.4 EDK37511.1 - 4.6e-11 42.0 5.0 8.3e-11 41.2 3.5 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal AATase PF07247.7 EDK37512.2 - 5e-62 210.0 0.0 6.4e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EDK37512.2 - 0.00094 18.1 0.0 0.025 13.4 0.0 2.2 2 0 0 2 2 2 2 Condensation domain GYF PF02213.11 EDK37513.2 - 4.3e-10 39.0 0.5 9.1e-10 37.9 0.3 1.6 1 0 0 1 1 1 1 GYF domain DUF1107 PF06526.7 EDK37513.2 - 0.015 15.1 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1107) WW PF00397.21 EDK37513.2 - 0.38 10.6 0.1 0.38 10.6 0.0 2.1 3 0 0 3 3 3 0 WW domain ORC5_C PF14630.1 EDK37514.2 - 3.2e-74 249.8 0.5 4.6e-74 249.2 0.3 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 EDK37514.2 - 1.1e-09 38.5 0.7 1.3e-08 35.0 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 EDK37514.2 - 5.9e-05 23.2 0.2 0.00021 21.4 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 EDK37514.2 - 0.001 19.2 0.1 0.026 14.7 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EDK37514.2 - 0.006 16.3 0.9 0.041 13.5 0.0 2.6 2 1 0 2 2 2 1 Archaeal ATPase NACHT PF05729.7 EDK37514.2 - 0.0075 15.9 0.2 0.021 14.5 0.1 1.7 1 1 0 1 1 1 1 NACHT domain AAA_14 PF13173.1 EDK37514.2 - 0.02 14.8 2.6 0.2 11.5 0.4 2.7 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 EDK37514.2 - 0.068 13.3 0.1 17 5.6 0.0 3.5 3 0 0 3 3 3 0 RNA helicase DUF1744 PF08490.7 EDK37515.2 - 5.1e-140 466.5 2.7 7.2e-140 466.0 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 EDK37515.2 - 1e-65 221.7 3.7 2.2e-65 220.6 2.5 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 EDK37515.2 - 1.6e-24 86.5 0.4 3.8e-24 85.3 0.3 1.5 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 EDK37515.2 - 1.3e-08 34.6 0.8 6.2e-08 32.4 0.2 2.5 3 0 0 3 3 3 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 EDK37515.2 - 4.7e-05 23.2 0.1 0.00025 20.9 0.0 2.3 1 0 0 1 1 1 1 RNase_H superfamily YIF1 PF03878.10 EDK37516.2 - 1.3e-66 224.1 11.1 1.7e-66 223.8 7.7 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 EDK37516.2 - 0.12 11.9 14.6 0.017 14.6 3.2 2.1 1 1 1 2 2 2 0 Yip1 domain Glyco_transf_20 PF00982.16 EDK37517.2 - 9.4e-200 664.0 0.0 1.1e-199 663.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.15 EDK37517.2 - 9.5e-06 25.1 0.3 0.019 14.4 0.0 2.7 2 1 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EDK37517.2 - 0.026 14.7 0.0 0.054 13.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 EDK37517.2 - 0.064 12.7 0.0 0.18 11.2 0.0 1.7 1 0 0 1 1 1 0 Starch synthase catalytic domain PP2C PF00481.16 EDK37519.2 - 3.8e-56 190.3 0.0 6.2e-54 183.0 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EDK37519.2 - 0.00028 20.3 0.0 0.00099 18.5 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C DUF377 PF04041.8 EDK37520.2 - 2.3e-48 164.5 0.1 2.7e-48 164.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF377) Glyco_hydro_32N PF00251.15 EDK37520.2 - 9.7e-11 41.5 2.6 1.3e-09 37.9 0.2 2.9 2 1 2 4 4 4 3 Glycosyl hydrolases family 32 N-terminal domain Ras PF00071.17 EDK37521.2 - 0.027 13.8 0.0 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 Ras family Miro PF08477.8 EDK37521.2 - 0.056 13.9 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein MMR_HSR1 PF01926.18 EDK37521.2 - 0.063 13.2 0.1 0.2 11.6 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase DASH_Duo1 PF08651.5 EDK37522.2 - 0.028 13.9 2.8 0.034 13.6 0.2 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF2730 PF10805.3 EDK37522.2 - 0.073 12.8 1.0 4 7.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) DUF4041 PF13250.1 EDK37522.2 - 0.27 10.8 2.2 14 5.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) ATP-synt_ab PF00006.20 EDK37523.2 - 1.3e-60 204.5 0.0 2.1e-60 203.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 EDK37523.2 - 1.4e-16 60.9 1.2 2.8e-16 59.9 0.8 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 EDK37523.2 - 2.1e-11 43.8 1.0 4.4e-11 42.8 0.7 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 EDK37523.2 - 0.00039 20.2 0.7 0.0011 18.8 0.5 1.7 1 0 0 1 1 1 1 HAS barrel domain Aconitase PF00330.15 EDK37524.2 - 4.2e-170 566.2 0.0 1.6e-169 564.2 0.0 1.9 2 1 0 2 2 2 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 EDK37524.2 - 8.4e-42 142.3 0.0 1.4e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain RasGEF PF00617.14 EDK37525.2 - 4.7e-49 166.6 4.9 6.5e-49 166.2 2.4 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 EDK37525.2 - 6.4e-16 58.3 1.0 3.3e-15 56.0 0.7 2.4 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.23 EDK37525.2 - 0.00019 20.7 0.0 0.00047 19.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK37525.2 - 0.06 12.9 0.0 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain AAA_12 PF13087.1 EDK37526.2 - 1.6e-58 197.4 0.1 2.9e-58 196.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EDK37526.2 - 8e-45 153.2 1.6 1.8e-44 152.1 1.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK37526.2 - 7.7e-11 41.6 0.0 1.6e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EDK37526.2 - 4.7e-10 39.3 0.0 8.2e-09 35.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 EDK37526.2 - 6.2e-06 25.8 0.0 0.11 12.0 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 EDK37526.2 - 2.4e-05 24.2 0.1 6.2e-05 22.9 0.1 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Arch_ATPase PF01637.13 EDK37526.2 - 0.00014 21.6 0.1 0.00036 20.2 0.1 1.7 1 1 0 1 1 1 1 Archaeal ATPase DUF2075 PF09848.4 EDK37526.2 - 0.00025 20.1 0.1 0.0042 16.1 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 EDK37526.2 - 0.00032 20.9 0.1 0.0012 19.0 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK37526.2 - 0.00063 19.8 0.0 0.0022 18.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.16 EDK37526.2 - 0.0007 18.9 0.1 0.0013 18.0 0.1 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.11 EDK37526.2 - 0.0008 18.6 0.2 0.012 14.8 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_16 PF13191.1 EDK37526.2 - 0.0024 17.8 0.0 0.0044 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.1 EDK37526.2 - 0.0027 17.8 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.9 EDK37526.2 - 0.0082 15.7 0.1 0.026 14.1 0.0 1.9 1 1 0 1 1 1 1 Helicase Miro PF08477.8 EDK37526.2 - 0.019 15.4 0.1 9.3 6.7 0.0 3.0 2 0 0 2 2 2 0 Miro-like protein DUF258 PF03193.11 EDK37526.2 - 0.027 13.6 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DEAD PF00270.24 EDK37526.2 - 0.066 12.6 2.0 0.4 10.1 1.4 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_25 PF13481.1 EDK37526.2 - 0.067 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain GBS_Bsp-like PF08481.5 EDK37526.2 - 0.12 12.2 0.6 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 GBS Bsp-like repeat AAA_23 PF13476.1 EDK37526.2 - 0.18 12.1 4.8 0.39 10.9 0.5 2.9 3 1 0 3 3 3 0 AAA domain Thioredoxin_4 PF13462.1 EDK37528.2 - 5e-09 36.3 0.1 1.4e-08 34.9 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EDK37528.2 - 0.0027 17.8 0.1 0.011 15.9 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.15 EDK37528.2 - 0.11 12.0 0.2 0.34 10.4 0.1 1.8 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Npa1 PF11707.3 EDK37529.2 - 0.058 12.3 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal SH3_1 PF00018.23 EDK37530.2 - 2.7e-22 77.8 0.0 9.2e-12 44.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 EDK37530.2 - 8.1e-16 57.3 0.1 3e-09 36.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.12 EDK37530.2 - 8.6e-12 44.3 0.0 1e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.19 EDK37530.2 - 2.2e-11 43.5 0.1 4.3e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 PX domain PB1 PF00564.19 EDK37530.2 - 0.011 15.3 0.1 0.028 14.0 0.0 1.7 1 0 0 1 1 1 0 PB1 domain Zn_clus PF00172.13 EDK37531.2 - 1.3e-07 31.4 12.1 2.5e-07 30.4 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.8 EDK37531.2 - 0.53 10.1 5.8 1 9.2 4.0 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Enolase_N PF03952.11 EDK37532.1 - 4.6e-52 175.4 0.0 5.5e-52 175.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, N-terminal domain Enolase_C PF00113.17 EDK37532.1 - 8.3e-05 21.6 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain ALS_ss_C PF10369.4 EDK37533.2 - 2e-19 69.0 0.0 1.1e-18 66.7 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.20 EDK37533.2 - 1.9e-11 43.1 0.1 4.5e-11 41.9 0.1 1.7 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 EDK37533.2 - 2.6e-06 27.1 0.0 4.2e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.1 EDK37533.2 - 0.12 12.1 0.2 20 4.9 0.0 2.7 3 0 0 3 3 3 0 ACT domain OPT PF03169.10 EDK37534.2 - 1.1e-167 559.2 37.6 1.3e-167 559.0 26.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4200 PF13863.1 EDK37535.2 - 0.0086 16.0 17.9 0.0086 16.0 12.4 4.3 1 1 3 4 4 4 1 Domain of unknown function (DUF4200) Reo_sigmaC PF04582.7 EDK37535.2 - 3 6.9 5.5 7.7 5.5 2.3 1.7 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF3812 PF12757.2 EDK37536.2 - 3.1e-25 88.6 6.7 3.1e-25 88.6 4.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3812) zf-C2H2 PF00096.21 EDK37537.2 - 1.7e-13 50.0 14.7 3.1e-07 30.3 1.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37537.2 - 1.7e-11 43.5 12.0 1.6e-06 28.0 1.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK37537.2 - 3e-08 33.5 19.1 3.1e-06 27.1 3.7 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EDK37537.2 - 1.3e-07 31.5 8.1 0.003 17.6 2.4 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 EDK37537.2 - 1.5e-05 24.6 3.6 0.008 15.9 1.2 2.4 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.1 EDK37537.2 - 0.0002 21.1 7.4 0.0073 16.1 1.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 EDK37537.2 - 0.00026 21.1 6.0 0.29 11.4 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 EDK37537.2 - 0.0092 16.0 5.4 0.095 12.8 0.5 2.3 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.7 EDK37537.2 - 0.016 15.3 6.3 0.059 13.5 4.4 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF535 PF04393.8 EDK37537.2 - 0.038 12.8 0.1 0.059 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF535) PyrI_C PF02748.10 EDK37537.2 - 0.11 11.9 0.5 0.23 10.9 0.4 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF629 PF04780.7 EDK37537.2 - 0.13 10.7 6.0 0.42 9.0 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-CHCC PF10276.4 EDK37537.2 - 1.9 8.3 5.1 1.3 8.9 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger domain Acetyltransf_1 PF00583.19 EDK37539.1 - 3.9e-14 52.4 0.0 5.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EDK37539.1 - 9e-07 29.1 0.0 1.1e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EDK37539.1 - 1.7e-06 28.0 0.0 2.1e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK37539.1 - 2e-05 24.6 0.0 4.3e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK37539.1 - 2.3e-05 24.5 0.0 2.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Mec-17 PF05301.6 EDK37539.1 - 0.0074 16.2 0.0 0.041 13.8 0.0 2.2 1 1 1 2 2 2 1 Touch receptor neuron protein Mec-17 Acetyltransf_9 PF13527.1 EDK37539.1 - 0.01 15.7 0.0 0.019 14.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK37539.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.6 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Fungal_trans_2 PF11951.3 EDK37540.2 - 5.1e-83 278.7 7.2 7e-83 278.3 5.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37540.2 - 1.6e-06 27.9 10.1 5.3e-06 26.2 7.0 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK37541.2 - 6.8e-11 41.5 0.1 1.3e-10 40.6 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37541.2 - 7.5e-09 35.3 10.8 1.2e-08 34.6 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Apc5 PF12862.2 EDK37541.2 - 0.1 12.4 0.6 0.32 10.8 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Swi3 PF07962.7 EDK37541.2 - 0.18 11.4 0.0 0.9 9.2 0.0 2.1 2 0 0 2 2 2 0 Replication Fork Protection Component Swi3 Sugar_tr PF00083.19 EDK37542.2 - 3.1e-88 296.3 26.9 3.6e-88 296.1 18.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37542.2 - 2.2e-16 59.5 32.2 3.4e-16 58.9 19.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK37542.2 - 1e-11 43.8 24.2 7.9e-06 24.5 0.8 3.3 2 1 1 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.19 EDK37543.2 - 3.2e-86 289.6 28.1 3.9e-86 289.4 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37543.2 - 7.8e-13 47.8 35.0 5.8e-11 41.7 20.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK37543.2 - 4.9e-10 38.3 31.3 1.1e-05 24.0 0.4 3.4 3 1 1 4 4 4 3 MFS/sugar transport protein Sugar_tr PF00083.19 EDK37544.1 - 2.7e-86 289.9 28.2 3.2e-86 289.7 19.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37544.1 - 2.2e-15 56.2 30.9 2.2e-13 49.6 17.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK37544.1 - 3.3e-10 38.9 34.4 7.3e-08 31.2 0.8 3.5 3 1 1 4 4 4 3 MFS/sugar transport protein Alpha-amylase PF00128.19 EDK37545.2 - 1.6e-100 336.5 3.1 2.9e-100 335.7 2.1 1.4 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 EDK37545.2 - 0.0024 16.8 0.1 0.0049 15.8 0.1 1.4 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme Glyco_hydro_42C PF08533.5 EDK37545.2 - 0.029 13.8 0.1 0.073 12.5 0.1 1.6 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain FHA PF00498.21 EDK37546.2 - 1.9e-14 53.5 0.0 3.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 EDK37546.2 - 6.9e-07 29.0 8.6 1.3e-06 28.0 6.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 EDK37546.2 - 0.0009 18.8 9.3 0.0017 18.0 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK37546.2 - 0.0082 15.9 4.5 0.016 15.0 3.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EDK37546.2 - 0.021 14.9 5.6 0.043 13.9 3.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK37546.2 - 0.028 14.1 6.5 0.05 13.3 4.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain FRG1 PF06229.7 EDK37546.2 - 0.18 11.2 3.1 0.33 10.3 2.2 1.3 1 0 0 1 1 1 0 FRG1-like family PHD PF00628.24 EDK37546.2 - 0.6 9.8 9.9 0.074 12.7 3.6 2.0 2 0 0 2 2 2 0 PHD-finger zf-C3HC4_2 PF13923.1 EDK37546.2 - 0.64 10.0 10.7 1.3 9.1 7.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 EDK37546.2 - 1.2 9.2 6.0 2.6 8.1 4.2 1.6 1 0 0 1 1 1 0 RING-like domain Hid1 PF12722.2 EDK37546.2 - 1.3 6.5 8.4 1.6 6.2 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.12 EDK37546.2 - 5.1 5.8 5.8 8.1 5.1 4.0 1.3 1 0 0 1 1 1 0 Presenilin Suf PF05843.9 EDK37546.2 - 7 6.2 9.8 11 5.6 6.8 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2417 PF10329.4 EDK37547.2 - 1.6e-80 269.8 9.3 2.6e-80 269.1 6.5 1.3 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 EDK37547.2 - 1.3e-13 51.3 0.0 2e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK37547.2 - 5.2e-06 26.1 0.0 8.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.15 EDK37547.2 - 8.6e-05 22.8 0.0 0.00013 22.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.2 EDK37547.2 - 0.00027 20.6 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family MRAP PF15183.1 EDK37547.2 - 0.4 10.3 2.4 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family PX PF00787.19 EDK37548.2 - 3.4e-12 46.1 1.9 4.4e-12 45.7 0.0 2.1 2 1 0 2 2 2 1 PX domain SNARE PF05739.14 EDK37548.2 - 8.1e-12 44.6 2.1 8.1e-12 44.6 1.5 2.0 2 0 0 2 2 2 1 SNARE domain AAA_13 PF13166.1 EDK37548.2 - 0.52 8.7 17.4 3.4 5.9 12.1 1.9 1 1 0 1 1 1 0 AAA domain MutS_III PF05192.13 EDK37548.2 - 2.5 7.8 7.8 45 3.7 5.4 2.4 1 1 0 1 1 1 0 MutS domain III THOC7 PF05615.8 EDK37548.2 - 5.6 7.2 14.3 1.3 9.2 1.5 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 PAP2 PF01569.16 EDK37549.2 - 3.4e-26 91.4 0.9 6.3e-26 90.5 0.7 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.1 EDK37549.2 - 0.17 12.1 2.0 0.24 11.7 0.3 2.2 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Aminotran_1_2 PF00155.16 EDK37550.1 - 1.8e-22 79.7 0.0 2.3e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EDK37550.1 - 0.00022 19.9 0.0 0.00029 19.5 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Prim-Pol PF09250.6 EDK37550.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Bifunctional DNA primase/polymerase, N-terminal EF-hand_6 PF13405.1 EDK37551.1 - 0.084 12.8 0.8 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain Rtt106 PF08512.7 EDK37552.2 - 9.3e-20 70.4 0.0 1.4e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Histone chaperone Rttp106-like SWIM PF04434.12 EDK37553.2 - 0.022 14.2 2.7 0.054 12.9 1.9 1.7 1 0 0 1 1 1 0 SWIM zinc finger Daxx PF03344.10 EDK37553.2 - 0.27 9.6 4.4 0.29 9.5 3.1 1.1 1 0 0 1 1 1 0 Daxx Family UCH PF00443.24 EDK37554.2 - 1.3e-54 185.1 0.0 2.4e-54 184.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK37554.2 - 9.7e-14 51.4 0.0 3.8e-13 49.5 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Flocculin_t3 PF13928.1 EDK37555.1 - 0.027 14.6 4.6 0.027 14.6 3.2 3.3 3 0 0 3 3 3 0 Flocculin type 3 repeat YCII PF03795.9 EDK37556.2 - 2.1e-06 27.8 0.0 2.6e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Aldo_ket_red PF00248.16 EDK37557.2 - 1.2e-62 211.2 0.1 1.4e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3782 PF12644.2 EDK37557.2 - 0.0021 17.7 0.0 0.75 9.6 0.0 3.2 2 1 0 2 2 2 2 Protein of unknown function (DUF3782) POP1 PF06978.6 EDK37558.2 - 1.3e-69 233.6 8.4 2.1e-69 232.9 5.8 1.4 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 EDK37558.2 - 2.6e-30 104.1 0.6 5.3e-30 103.0 0.4 1.6 1 0 0 1 1 1 1 POPLD (NUC188) domain AIP3 PF03915.8 EDK37558.2 - 0.034 13.0 0.3 0.057 12.3 0.2 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Ssu72 PF04722.8 EDK37559.2 - 2.8e-89 297.6 1.1 3.2e-89 297.4 0.8 1.0 1 0 0 1 1 1 1 Ssu72-like protein GIDA PF01134.17 EDK37559.2 - 0.036 12.9 0.0 0.044 12.6 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A DrrA_P4M PF14860.1 EDK37559.2 - 0.074 12.8 1.5 0.12 12.1 1.0 1.3 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain G-patch PF01585.18 EDK37560.2 - 2.4e-10 40.0 1.2 2.4e-10 40.0 0.8 1.9 2 0 0 2 2 2 1 G-patch domain R3H PF01424.17 EDK37560.2 - 0.025 14.2 0.0 0.077 12.6 0.0 1.9 2 0 0 2 2 2 0 R3H domain Peptidase_C54 PF03416.14 EDK37561.2 - 2.6e-64 217.0 0.0 2.1e-62 210.8 0.0 2.4 1 1 0 1 1 1 1 Peptidase family C54 zf-C2H2_jaz PF12171.3 EDK37562.2 - 1.1e-10 41.3 9.6 1.2e-07 31.6 4.0 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EDK37562.2 - 3.9e-10 39.7 1.6 0.00022 21.2 0.1 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 EDK37562.2 - 4.2e-09 36.2 9.3 1.3e-06 28.4 2.0 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 EDK37562.2 - 4e-06 26.8 7.8 0.022 15.1 0.3 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37562.2 - 6.9e-06 26.0 3.8 0.055 13.8 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EDK37562.2 - 0.0032 17.2 2.8 0.048 13.5 0.1 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-FCS PF06467.9 EDK37562.2 - 0.029 14.0 3.4 1.7 8.3 0.1 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Astro_capsid PF03115.9 EDK37562.2 - 0.16 10.1 9.1 0.19 9.9 6.3 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor AKAP95 PF04988.7 EDK37562.2 - 1 9.1 9.4 0.28 10.9 2.1 2.3 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) DnaJ PF00226.26 EDK37563.2 - 3.3e-26 90.7 0.1 8.9e-26 89.4 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain Rubrerythrin PF02915.12 EDK37563.2 - 0.081 13.2 4.6 0.13 12.5 0.2 2.6 1 1 1 2 2 2 0 Rubrerythrin Hydantoinase_B PF02538.9 EDK37565.2 - 9.4e-188 624.7 0.3 1.3e-187 624.2 0.2 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EDK37565.2 - 1.2e-80 270.7 0.0 2.2e-80 269.8 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EDK37565.2 - 1.4e-51 174.4 0.2 9.7e-49 165.2 0.0 3.0 4 0 0 4 4 4 2 Hydantoinase/oxoprolinase N-terminal region FAD_binding_3 PF01494.14 EDK37566.2 - 1.7e-11 43.8 0.2 5.6e-10 38.8 0.1 2.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EDK37566.2 - 3.5e-08 32.7 1.6 6.3e-06 25.3 1.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EDK37566.2 - 1.3e-07 31.5 0.4 2.9e-07 30.4 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 EDK37566.2 - 6.6e-07 28.5 0.0 9.9e-07 27.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 EDK37566.2 - 7.7e-05 22.6 1.9 0.00047 20.0 1.3 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 EDK37566.2 - 0.00019 20.3 1.0 0.00029 19.8 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EDK37566.2 - 0.00037 19.6 0.0 0.0005 19.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EDK37566.2 - 0.00092 18.3 0.1 0.14 11.2 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.22 EDK37566.2 - 0.0014 18.9 2.5 0.0015 18.9 0.4 2.1 3 0 0 3 3 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK37566.2 - 0.006 15.1 1.8 0.01 14.3 0.9 1.6 2 0 0 2 2 2 1 HI0933-like protein SE PF08491.5 EDK37566.2 - 0.019 13.7 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase GIDA PF01134.17 EDK37566.2 - 0.027 13.3 1.9 0.055 12.3 1.3 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 EDK37566.2 - 0.071 12.6 0.3 0.87 9.1 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 EDK37566.2 - 0.11 11.5 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.9 EDK37566.2 - 0.19 10.3 1.2 0.9 8.0 0.3 2.3 2 1 1 3 3 3 0 Tryptophan halogenase Zn_clus PF00172.13 EDK37567.2 - 8.5e-08 31.9 11.7 1.4e-07 31.2 8.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EDK37568.2 - 1.7e-23 82.9 21.8 2.4e-23 82.4 15.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK37568.2 - 0.00061 18.1 1.4 0.00089 17.5 1.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Strabismus PF06638.6 EDK37568.2 - 0.0048 15.2 2.0 0.0069 14.7 1.4 1.1 1 0 0 1 1 1 1 Strabismus protein DUF480 PF04337.7 EDK37569.2 - 0.064 13.1 0.4 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF480 Flg_hook PF02120.11 EDK37569.2 - 0.095 12.3 0.0 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK DUF883 PF05957.8 EDK37569.2 - 0.1 13.0 0.1 0.1 13.0 0.0 4.9 2 2 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF2937 PF11157.3 EDK37569.2 - 0.34 10.2 4.2 0.44 9.8 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) tRNA-synt_2b PF00587.20 EDK37570.2 - 2.3e-31 108.6 0.0 3.9e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EDK37570.2 - 9.9e-08 31.8 0.0 2.2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 EDK37570.2 - 0.13 11.0 0.0 0.29 9.8 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) RRM_1 PF00076.17 EDK37571.2 - 2.1e-07 30.4 0.0 1.1e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37571.2 - 5.6e-07 29.4 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37571.2 - 0.00015 21.5 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PBP1_TM PF14812.1 EDK37571.2 - 0.0063 16.7 3.5 0.0063 16.7 2.4 2.0 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 EDK37571.2 - 0.059 12.8 4.2 0.11 12.0 2.9 1.3 1 0 0 1 1 1 0 Nucleoplasmin CENP-B_dimeris PF09026.5 EDK37571.2 - 0.13 12.5 4.3 0.24 11.6 3.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2956 PF11169.3 EDK37571.2 - 0.14 12.1 0.8 11 6.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) NOA36 PF06524.7 EDK37571.2 - 4.3 6.5 5.4 7 5.8 3.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2076 PF09849.4 EDK37571.2 - 8.1 6.4 12.8 5.1 7.0 6.9 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Pol_alpha_B_N PF08418.5 EDK37571.2 - 8.3 5.8 15.6 0.17 11.4 1.0 2.8 2 1 1 3 3 3 0 DNA polymerase alpha subunit B N-terminal DUF912 PF06024.7 EDK37572.2 - 0.012 15.7 2.5 0.022 14.8 1.7 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Shisa PF13908.1 EDK37572.2 - 0.013 15.6 0.1 0.02 15.0 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator AJAP1_PANP_C PF15298.1 EDK37572.2 - 0.047 13.5 0.1 0.082 12.7 0.1 1.5 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Rifin_STEVOR PF02009.11 EDK37572.2 - 0.075 12.6 1.0 0.11 12.1 0.7 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF3377 PF11857.3 EDK37572.2 - 0.28 10.8 4.0 0.64 9.6 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF3827 PF12877.2 EDK37572.2 - 0.53 8.3 1.9 0.75 7.8 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) EphA2_TM PF14575.1 EDK37572.2 - 0.57 10.6 3.3 1.1 9.6 2.3 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PP2C PF00481.16 EDK37573.2 - 1.3e-73 247.5 0.0 1.8e-73 247.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EDK37573.2 - 0.051 12.9 0.0 0.12 11.7 0.0 1.8 1 1 0 1 1 1 0 Protein phosphatase 2C Glyco_hydro_25 PF01183.15 EDK37573.2 - 0.11 12.3 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 25 MOZ_SAS PF01853.13 EDK37574.2 - 3.7e-74 248.0 1.5 5.5e-74 247.4 1.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family LRR19-TM PF15176.1 EDK37574.2 - 0.35 10.5 4.9 4.2 7.1 0.2 2.5 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain TatD_DNase PF01026.16 EDK37575.1 - 1.7e-42 145.3 0.0 4.2e-42 144.1 0.0 1.6 1 1 0 1 1 1 1 TatD related DNase DnaJ PF00226.26 EDK37576.2 - 7.6e-08 31.9 1.0 1.7e-07 30.8 0.1 2.1 2 0 0 2 2 2 1 DnaJ domain Bin3 PF06859.7 EDK37576.2 - 0.054 13.4 0.8 0.1 12.6 0.1 1.8 1 1 1 2 2 2 0 Bicoid-interacting protein 3 (Bin3) PTH2 PF01981.11 EDK37577.2 - 3.1e-46 155.8 0.4 4.2e-46 155.3 0.3 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF4611 PF15387.1 EDK37577.2 - 0.011 15.7 0.9 0.022 14.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.5 EDK37577.2 - 0.015 15.5 0.8 0.021 15.0 0.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Myb_DNA-bind_6 PF13921.1 EDK37578.2 - 3.4e-11 43.0 0.8 4.7e-10 39.4 0.1 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EDK37578.2 - 8.3e-07 28.9 1.4 4.7e-05 23.3 0.2 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Chorismate_bind PF00425.13 EDK37579.2 - 2.3e-89 299.1 0.0 3.4e-89 298.5 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 EDK37579.2 - 1.2e-30 106.3 0.3 1.6e-27 96.1 0.0 3.3 2 1 0 3 3 3 1 Anthranilate synthase component I, N terminal region DUF2312 PF10073.4 EDK37579.2 - 0.018 14.3 0.0 0.093 12.0 0.0 2.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) POR PF01558.13 EDK37579.2 - 0.078 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase RNB PF00773.14 EDK37580.2 - 0.00014 21.2 5.0 0.077 12.2 0.0 2.9 3 0 0 3 3 3 2 RNB domain AMP-binding PF00501.23 EDK37581.2 - 1.8e-77 260.5 0.0 2.2e-77 260.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FAD-oxidase_C PF02913.14 EDK37582.2 - 1.1e-58 198.4 0.0 1.8e-58 197.7 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EDK37582.2 - 3.9e-36 123.5 0.0 7.5e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain UPF0029 PF01205.14 EDK37583.2 - 1.8e-29 101.6 0.0 2.6e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Ribosomal_L14 PF00238.14 EDK37584.1 - 4.9e-49 165.1 0.8 5.5e-49 164.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e tRNA-synt_2b PF00587.20 EDK37585.1 - 2.2e-46 157.6 0.3 3.6e-46 156.8 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EDK37585.1 - 3.1e-18 65.5 2.0 8.5e-18 64.0 0.4 2.3 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.9 EDK37585.1 - 1.3e-13 50.5 0.0 3.4e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 EDK37585.1 - 1.2e-08 34.6 0.0 5e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 TGS domain DUF1689 PF07954.6 EDK37586.2 - 3e-56 189.4 1.2 3.9e-56 189.1 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Rad10 PF03834.9 EDK37586.2 - 0.078 12.6 0.3 9.7 5.9 0.1 2.4 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) O-antigen_lig PF13425.1 EDK37586.2 - 0.085 12.8 0.0 0.75 9.7 0.0 2.0 1 1 1 2 2 2 0 O-antigen ligase like membrane protein Coatomer_E PF04733.9 EDK37587.2 - 9.7e-14 51.2 7.8 1.1e-12 47.8 5.4 2.3 1 1 0 1 1 1 1 Coatomer epsilon subunit Ground-like PF04155.13 EDK37587.2 - 0.12 12.6 0.3 0.28 11.5 0.2 1.6 1 0 0 1 1 1 0 Ground-like domain Septin PF00735.13 EDK37588.2 - 6.4e-81 271.4 1.3 6.4e-81 271.4 0.9 2.0 2 1 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EDK37588.2 - 4.8e-07 29.7 0.0 1.3e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EDK37588.2 - 0.00019 20.6 0.0 0.00033 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 EDK37588.2 - 0.00098 18.2 0.0 0.0025 16.9 0.0 1.7 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 EDK37588.2 - 0.0028 17.1 0.1 0.071 12.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EDK37588.2 - 0.0044 17.5 0.1 0.014 15.8 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein IIGP PF05049.8 EDK37588.2 - 0.018 13.8 0.2 0.018 13.8 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.13 EDK37588.2 - 0.035 13.4 0.7 0.1 11.8 0.1 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_33 PF13671.1 EDK37588.2 - 0.056 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EDK37588.2 - 0.071 13.4 5.2 0.029 14.6 1.2 2.3 2 1 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 EDK37588.2 - 0.079 12.5 0.5 0.17 11.4 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.18 EDK37588.2 - 0.2 11.4 5.5 0.068 12.9 0.9 2.5 2 1 0 2 2 2 0 Dynamin family AAA_17 PF13207.1 EDK37588.2 - 2.7 8.8 7.8 0.65 10.8 0.1 3.0 2 2 0 2 2 2 0 AAA domain KRE9 PF05390.6 EDK37589.2 - 9.5e-27 93.4 13.1 9.5e-27 93.4 9.1 1.9 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 EDK37589.2 - 1.2e-11 44.9 0.6 1.2e-11 44.9 0.4 2.8 2 1 2 4 4 4 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Pox_P4B PF03292.9 EDK37589.2 - 0.15 9.9 0.2 0.21 9.5 0.1 1.1 1 0 0 1 1 1 0 Poxvirus P4B major core protein Aldedh PF00171.17 EDK37590.2 - 1e-153 512.0 0.0 1.2e-153 511.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldo_ket_red PF00248.16 EDK37591.2 - 1.9e-63 213.9 0.0 2.3e-63 213.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Arginase PF00491.16 EDK37592.2 - 1.3e-85 287.0 0.3 1.7e-85 286.7 0.2 1.1 1 0 0 1 1 1 1 Arginase family WSC PF01822.14 EDK37593.2 - 2.1e-10 40.3 13.7 2.1e-10 40.3 9.5 2.7 2 1 0 2 2 1 1 WSC domain DUF1191 PF06697.7 EDK37593.2 - 0.00029 19.7 0.4 0.00041 19.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) DUF1517 PF07466.6 EDK37593.2 - 0.00041 19.4 3.2 0.00041 19.4 2.2 3.0 1 1 2 3 3 2 1 Protein of unknown function (DUF1517) Syndecan PF01034.15 EDK37593.2 - 0.0025 17.4 0.0 0.007 15.9 0.0 1.7 1 0 0 1 1 1 1 Syndecan domain EphA2_TM PF14575.1 EDK37593.2 - 0.0034 17.7 0.0 0.021 15.2 0.0 2.4 3 0 0 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain DUF912 PF06024.7 EDK37593.2 - 0.0035 17.3 0.1 0.075 13.0 0.1 2.3 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 EDK37593.2 - 0.0044 15.3 1.6 0.0066 14.7 0.0 1.8 1 1 1 2 2 2 1 Alphaherpesvirus glycoprotein E SKG6 PF08693.5 EDK37593.2 - 0.0054 16.0 2.0 0.026 13.8 1.4 2.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 EDK37593.2 - 0.013 15.2 0.1 0.013 15.2 0.0 2.3 1 1 1 2 2 1 0 TMEM154 protein family SOBP PF15279.1 EDK37593.2 - 0.18 12.1 7.6 0.35 11.2 5.3 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.2 EDK37593.2 - 0.93 7.0 6.5 1.1 6.8 4.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.12 EDK37593.2 - 1.5 7.5 9.0 2.2 6.9 6.3 1.3 1 0 0 1 1 1 0 Presenilin Podoplanin PF05808.6 EDK37593.2 - 9.7 5.7 21.6 65 3.0 15.0 2.0 1 1 0 1 1 1 0 Podoplanin DUF2408 PF10303.4 EDK37594.2 - 1e-61 206.9 22.2 9.6e-41 139.0 1.8 5.3 2 2 3 5 5 5 5 Protein of unknown function (DUF2408) Baculo_p24 PF05073.7 EDK37594.2 - 0.011 15.3 8.2 0.096 12.2 0.1 3.8 2 1 2 4 4 4 0 Baculovirus P24 capsid protein Flp_N PF03930.9 EDK37594.2 - 0.041 13.6 0.1 0.31 10.8 0.0 2.5 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus Cut8_C PF08559.5 EDK37595.2 - 6.4e-58 194.6 1.6 9.5e-58 194.0 1.1 1.3 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 EDK37595.2 - 1e-13 50.7 2.3 3.2e-13 49.2 1.6 1.9 1 0 0 1 1 1 1 Cut8 dimerisation domain Cut8_N PF14482.1 EDK37595.2 - 1.9e-08 34.1 1.8 3.3e-08 33.3 1.2 1.4 1 0 0 1 1 1 1 Cut8 proteasome-binding domain Rrn6 PF10214.4 EDK37595.2 - 0.0061 14.7 0.4 0.0068 14.5 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor BING4CT PF08149.6 EDK37596.2 - 5.1e-37 125.2 0.0 1.5e-35 120.5 0.0 2.7 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.27 EDK37596.2 - 3.2e-07 29.9 0.3 1.9e-05 24.3 0.0 3.6 4 0 0 4 4 4 1 WD domain, G-beta repeat VirArc_Nuclease PF12187.3 EDK37596.2 - 8.4e-05 22.0 0.1 0.00018 20.9 0.1 1.5 1 0 0 1 1 1 1 Viral/Archaeal nuclease DHO_dh PF01180.16 EDK37597.2 - 1.5e-96 322.8 0.0 1.8e-96 322.6 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 EDK37597.2 - 0.016 14.0 0.1 0.14 10.9 0.1 2.2 2 1 0 2 2 2 0 FMN-dependent dehydrogenase DASH_Dam1 PF08653.5 EDK37598.2 - 7.9e-30 102.4 0.4 2.3e-28 97.7 0.0 2.2 2 0 0 2 2 2 1 DASH complex subunit Dam1 IncA PF04156.9 EDK37598.2 - 0.00043 19.9 0.1 0.0012 18.4 0.0 1.6 2 0 0 2 2 2 1 IncA protein FlaC_arch PF05377.6 EDK37598.2 - 0.0011 18.8 0.4 0.76 9.7 0.3 2.2 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) Leu_zip PF15294.1 EDK37598.2 - 0.0014 17.7 0.1 0.0023 17.1 0.0 1.3 1 0 0 1 1 1 1 Leucine zipper Med9 PF07544.8 EDK37598.2 - 0.0026 17.4 1.7 0.0026 17.4 1.2 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 HOOK PF05622.7 EDK37598.2 - 0.0098 13.7 0.2 0.016 13.0 0.1 1.3 2 0 0 2 2 2 1 HOOK protein Prefoldin PF02996.12 EDK37598.2 - 0.015 14.9 0.4 0.084 12.5 0.2 1.9 2 0 0 2 2 2 0 Prefoldin subunit DivIC PF04977.10 EDK37598.2 - 0.024 14.1 1.1 0.046 13.2 0.8 1.4 1 0 0 1 1 1 0 Septum formation initiator Atg14 PF10186.4 EDK37598.2 - 0.025 13.5 0.4 0.035 13.0 0.3 1.3 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF812 PF05667.6 EDK37598.2 - 0.027 13.0 0.7 0.049 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF904 PF06005.7 EDK37598.2 - 0.034 14.4 1.5 0.059 13.6 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF972 PF06156.8 EDK37598.2 - 0.041 14.2 1.0 0.14 12.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Ax_dynein_light PF10211.4 EDK37598.2 - 0.058 13.2 1.0 0.35 10.6 0.6 1.9 2 0 0 2 2 2 0 Axonemal dynein light chain BLOC1_2 PF10046.4 EDK37598.2 - 0.12 12.5 0.7 9.2 6.4 0.2 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.13 EDK37598.2 - 0.13 12.2 0.6 0.39 10.7 0.1 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family HR1 PF02185.11 EDK37598.2 - 0.44 10.3 3.5 0.39 10.4 1.0 1.8 2 0 0 2 2 2 0 Hr1 repeat Vps51 PF08700.6 EDK37598.2 - 0.57 10.0 2.8 3.6 7.5 0.4 2.2 2 0 0 2 2 2 0 Vps51/Vps67 bZIP_2 PF07716.10 EDK37598.2 - 4.6 7.1 8.8 0.1 12.4 1.2 1.9 2 0 0 2 2 1 0 Basic region leucine zipper GET2 PF08690.5 EDK37599.2 - 1.5e-64 218.1 0.0 2.4e-64 217.5 0.0 1.2 1 0 0 1 1 1 1 GET complex subunit GET2 SURF1 PF02104.10 EDK37600.2 - 9.2e-59 198.8 0.0 1.2e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Med10 PF09748.4 EDK37602.1 - 4.8e-36 123.4 0.1 5.9e-36 123.1 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.2 EDK37602.1 - 0.13 11.8 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) CMD PF02627.15 EDK37605.2 - 4.4e-07 29.6 0.0 2.8e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family MKT1_C PF12246.3 EDK37605.2 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication MFS_1 PF07690.11 EDK37606.2 - 6.9e-38 130.2 37.3 7.6e-38 130.1 19.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK37606.2 - 3.1e-15 55.6 19.6 5.4e-15 54.9 13.6 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EDK37606.2 - 2.5e-05 22.7 0.7 3.9e-05 22.0 0.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF792 PF05632.6 EDK37606.2 - 0.28 10.4 1.6 0.84 8.9 0.3 2.2 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF792) AFG1_ATPase PF03969.11 EDK37607.2 - 7.3e-60 202.6 0.2 1.1e-56 192.2 0.0 3.4 2 1 1 3 3 3 2 AFG1-like ATPase AAA_22 PF13401.1 EDK37607.2 - 0.012 15.7 0.0 0.065 13.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 EDK37607.2 - 0.039 14.2 0.4 2.6 8.3 0.0 2.8 2 1 1 3 3 3 0 ABC transporter NACHT PF05729.7 EDK37607.2 - 0.048 13.3 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 EDK37607.2 - 0.054 13.7 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 EDK37607.2 - 0.063 13.4 0.3 0.96 9.6 0.0 3.0 4 0 0 4 4 4 0 RNA helicase Mg_chelatase PF01078.16 EDK37607.2 - 0.17 11.0 0.0 0.33 10.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Myotub-related PF06602.9 EDK37608.2 - 1.7e-120 402.0 0.6 2.3e-120 401.5 0.4 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.22 EDK37608.2 - 0.0036 16.6 0.1 0.0089 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 EDK37608.2 - 0.0036 17.5 0.2 0.013 15.8 0.0 2.1 2 1 0 2 2 2 1 Tyrosine phosphatase family IL7 PF01415.11 EDK37608.2 - 0.039 13.6 0.1 0.085 12.5 0.1 1.5 1 0 0 1 1 1 0 Interleukin 7/9 family NMT PF01233.14 EDK37608.2 - 0.19 11.3 1.4 0.46 10.0 0.9 1.6 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain WD40 PF00400.27 EDK37609.2 - 3.6e-06 26.6 3.7 0.23 11.4 0.2 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat CENP-T PF15511.1 EDK37609.2 - 0.0011 18.2 13.5 0.0015 17.8 9.3 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T TFIIF_alpha PF05793.7 EDK37609.2 - 0.0015 16.9 25.9 0.0015 16.9 17.9 1.6 2 0 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.7 EDK37609.2 - 0.081 10.8 35.1 0.015 13.2 21.6 1.8 2 0 0 2 2 2 0 Nop14-like family SDA1 PF05285.7 EDK37609.2 - 0.13 11.4 40.9 0.0091 15.3 23.6 2.1 2 0 0 2 2 2 0 SDA1 TMEM237 PF15383.1 EDK37609.2 - 4.5 6.3 7.0 1.3 8.0 0.0 2.8 3 0 0 3 3 3 0 Transmembrane protein 237 Oxysterol_BP PF01237.13 EDK37610.2 - 3e-125 417.3 0.0 5.1e-125 416.6 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_2 PF12796.2 EDK37610.2 - 2.7e-18 66.0 0.0 1.1e-11 44.8 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EDK37610.2 - 5.3e-16 58.2 0.2 1.5e-07 31.3 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 EDK37610.2 - 6.4e-15 55.2 0.0 3.7e-10 40.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 EDK37610.2 - 9.7e-14 50.3 0.1 4.3e-07 29.4 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 EDK37610.2 - 3.1e-12 45.4 0.1 3.9e-06 26.5 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat PH PF00169.24 EDK37610.2 - 9.2e-09 35.4 0.1 2.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 EDK37610.2 - 1.8e-07 31.1 0.3 4.6e-07 29.8 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 EDK37610.2 - 0.0022 18.2 6.9 0.0023 18.1 0.2 3.4 3 0 0 3 3 3 1 Pleckstrin homology domain RRM_5 PF13893.1 EDK37611.2 - 7.9e-09 35.2 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK37611.2 - 2.8e-06 26.8 0.0 6.6e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37611.2 - 0.094 12.7 0.0 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NAD_binding_8 PF13450.1 EDK37612.2 - 1.4e-13 50.6 0.0 3.4e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EDK37612.2 - 2.3e-09 36.8 0.0 1.2e-06 27.9 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.19 EDK37612.2 - 1.9e-06 27.0 0.0 3.3e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 EDK37612.2 - 8.5e-06 25.0 0.0 0.00053 19.1 0.0 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.22 EDK37612.2 - 2.5e-05 24.5 0.2 0.00066 20.0 0.0 3.1 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EDK37612.2 - 0.001 18.9 0.1 0.0063 16.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK37612.2 - 0.0023 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EDK37612.2 - 0.0034 17.4 0.0 0.007 16.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.10 EDK37612.2 - 0.0035 15.5 0.0 0.0067 14.6 0.0 1.3 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) Ubiquitin_2 PF14560.1 EDK37612.2 - 0.021 15.1 0.1 0.14 12.3 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain NAD_Gly3P_dh_N PF01210.18 EDK37612.2 - 0.1 12.3 0.0 2.4 7.8 0.0 2.7 1 1 2 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Arrestin_C PF02752.17 EDK37613.2 - 1.5e-27 96.3 6.7 8.4e-27 93.9 2.7 3.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EDK37613.2 - 4.2e-05 23.4 0.1 0.0012 18.6 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Adeno_E3B PF03376.9 EDK37614.2 - 1.2 9.1 4.4 6.4 6.7 1.1 2.6 2 1 0 2 2 2 0 Adenovirus E3B protein adh_short PF00106.20 EDK37616.2 - 2.8e-29 102.1 0.6 3.5e-29 101.8 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK37616.2 - 6.6e-24 84.9 0.1 8e-24 84.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK37616.2 - 5.6e-15 55.4 0.3 8.5e-15 54.8 0.2 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EDK37616.2 - 0.0048 15.8 0.0 0.0065 15.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 EDK37616.2 - 0.022 15.1 0.1 0.083 13.3 0.1 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.16 EDK37616.2 - 0.067 12.6 0.1 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Kinesin PF00225.18 EDK37617.2 - 2.5e-107 358.4 1.3 4.1e-107 357.7 0.9 1.3 1 0 0 1 1 1 1 Kinesin motor domain Fib_alpha PF08702.5 EDK37617.2 - 0.35 10.9 15.4 4.5 7.3 6.0 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF87 PF01935.12 EDK37617.2 - 1.3 8.7 10.9 1.2 8.9 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF87 Muted PF14942.1 EDK37617.2 - 1.5 8.7 12.8 0.36 10.7 6.1 2.0 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein 2-Hacid_dh_C PF02826.14 EDK37618.2 - 4.8e-54 182.2 0.0 8.2e-54 181.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EDK37618.2 - 1.5e-37 128.0 0.1 2e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EDK37618.2 - 3.9e-05 23.5 0.4 9.7e-05 22.2 0.3 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 EDK37618.2 - 0.00027 20.8 0.1 0.00056 19.7 0.1 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.20 EDK37618.2 - 0.00042 19.7 0.0 0.00097 18.5 0.0 1.6 1 0 0 1 1 1 1 ACT domain Acetyltransf_1 PF00583.19 EDK37618.2 - 0.0067 16.4 0.0 0.087 12.8 0.0 2.3 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family XdhC_C PF13478.1 EDK37618.2 - 0.015 15.6 0.0 0.047 13.9 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain IlvN PF07991.7 EDK37618.2 - 0.045 13.1 0.2 0.1 11.9 0.1 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 EDK37618.2 - 0.066 12.8 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PC_rep PF01851.17 EDK37619.2 - 2.2e-14 52.7 9.6 2e-05 24.5 0.0 4.7 4 0 0 4 4 4 3 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EDK37619.2 - 0.00072 19.7 0.1 0.071 13.3 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats TPR_6 PF13174.1 EDK37619.2 - 0.065 13.7 0.3 93 3.8 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF2408 PF10303.4 EDK37619.2 - 0.068 13.2 0.1 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) DNA_alkylation PF08713.6 EDK37619.2 - 0.073 12.5 0.0 0.2 11.1 0.0 1.7 1 0 0 1 1 1 0 DNA alkylation repair enzyme PC_rep PF01851.17 EDK37620.2 - 4.8e-24 83.1 13.5 4.1e-06 26.7 0.1 6.1 6 0 0 6 6 6 4 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EDK37620.2 - 5.4e-14 52.2 0.0 3.2e-13 49.7 0.0 2.2 1 1 1 2 2 2 1 HEAT repeats HEAT PF02985.17 EDK37620.2 - 6.1e-07 28.9 0.0 0.19 11.8 0.0 3.6 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.1 EDK37620.2 - 3.7e-05 24.0 0.1 0.032 14.7 0.0 3.0 1 1 2 3 3 3 3 HEAT-like repeat HEAT_PBS PF03130.11 EDK37620.2 - 0.015 15.7 0.2 1 9.9 0.1 3.0 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat PPP4R2 PF09184.6 EDK37620.2 - 0.16 11.5 8.6 0.24 10.8 6.0 1.2 1 0 0 1 1 1 0 PPP4R2 Exo_endo_phos PF03372.18 EDK37621.2 - 1e-09 38.6 0.0 1.5e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EDK37621.2 - 3.8e-06 26.5 0.2 1.4e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase DAGK_cat PF00781.19 EDK37622.2 - 1.8e-24 85.6 0.0 2.9e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PCI PF01399.22 EDK37624.2 - 4.6e-10 39.7 1.6 2.5e-09 37.4 0.5 2.4 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 EDK37624.2 - 0.00011 22.0 6.6 0.00071 19.3 1.0 3.0 2 1 0 2 2 2 2 COP9 signalosome, subunit CSN8 V-ATPase_C PF03223.10 EDK37625.2 - 4.2e-113 378.0 0.5 4.7e-113 377.8 0.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C SURF6 PF04935.7 EDK37626.2 - 3.6e-50 170.2 46.1 3.6e-50 170.2 31.9 2.6 1 1 0 2 2 2 1 Surfeit locus protein 6 Adaptin_N PF01602.15 EDK37628.2 - 1.1e-120 403.4 2.1 1.3e-120 403.1 1.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 EDK37628.2 - 6.4e-18 65.1 0.4 1.5e-17 63.9 0.3 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.2 EDK37628.2 - 0.00013 21.8 0.6 0.028 14.2 0.2 2.8 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EDK37628.2 - 0.0003 21.0 1.1 0.47 10.7 0.0 3.8 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.17 EDK37628.2 - 0.041 13.9 0.5 42 4.5 0.0 4.3 3 1 0 3 3 3 0 HEAT repeat Pro_isomerase PF00160.16 EDK37629.2 - 1.7e-10 41.2 0.2 1.7e-10 41.2 0.2 2.1 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Hid1 PF12722.2 EDK37629.2 - 3.6 5.1 23.0 4.7 4.7 15.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pkinase PF00069.20 EDK37630.2 - 4e-39 134.3 0.2 1.9e-19 69.8 0.0 4.0 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37630.2 - 4.5e-13 48.8 0.0 0.001 18.1 0.0 3.9 4 0 0 4 4 4 3 Protein tyrosine kinase Acyltransferase PF01553.16 EDK37631.2 - 4.7e-16 58.4 0.0 1.2e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase Gly_transf_sug PF04488.10 EDK37632.2 - 2.2e-19 69.7 0.0 4e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EDK37632.2 - 0.27 9.6 2.6 4.4 5.6 0.2 2.1 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain RNase_PH PF01138.16 EDK37633.2 - 2.7e-20 73.0 0.0 4.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EDK37633.2 - 4.7e-08 32.8 0.1 1.1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Band_7 PF01145.20 EDK37634.2 - 2e-31 109.2 0.2 2e-31 109.2 0.1 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 EDK37634.2 - 0.006 16.1 0.1 0.012 15.1 0.0 1.6 1 1 0 1 1 1 1 SPFH domain-Band 7 family BON PF04972.12 EDK37634.2 - 0.096 12.4 0.7 0.43 10.3 0.2 2.2 1 1 1 2 2 2 0 BON domain RNase_H2-Ydr279 PF09468.5 EDK37635.2 - 3.8e-61 206.9 5.9 4.4e-61 206.7 4.1 1.0 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) Ded_cyto PF06920.8 EDK37635.2 - 0.0076 15.5 0.2 0.2 10.9 0.0 2.1 2 0 0 2 2 2 1 Dedicator of cytokinesis MIS13 PF08202.6 EDK37635.2 - 0.047 12.7 1.0 0.064 12.3 0.7 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family SopA PF13981.1 EDK37635.2 - 0.058 13.4 2.8 1.5 8.8 0.1 2.9 2 1 1 3 3 3 0 SopA-like central domain Flagellin_N PF00669.15 EDK37635.2 - 0.21 11.3 4.0 0.15 11.8 0.9 1.9 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Rpp20 PF12328.3 EDK37635.2 - 0.69 9.5 5.0 1.5 8.5 3.5 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Med10 PF09748.4 EDK37635.2 - 1.2 8.9 4.5 0.59 9.9 0.4 2.2 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex LrgB PF04172.11 EDK37636.2 - 1.3e-23 83.3 9.1 8.1e-23 80.7 3.5 2.1 2 0 0 2 2 2 2 LrgB-like family Pombe_5TM PF09437.5 EDK37637.1 - 0.86 8.9 5.2 0.34 10.3 1.8 1.6 1 1 1 2 2 2 0 Pombe specific 5TM protein zf-CHCC PF10276.4 EDK37638.1 - 2e-13 49.9 0.7 3e-13 49.3 0.2 1.6 2 0 0 2 2 2 1 Zinc-finger domain Ras PF00071.17 EDK37639.1 - 4.4e-57 191.9 0.0 5.2e-57 191.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK37639.1 - 3.6e-16 59.7 0.0 6.8e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK37639.1 - 2.1e-08 33.6 0.0 3.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK37639.1 - 0.00014 21.3 0.0 0.00059 19.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EDK37639.1 - 0.0021 17.2 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 EDK37639.1 - 0.0062 15.7 0.0 0.011 15.0 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit tRNA_m1G_MT PF01746.16 EDK37640.2 - 3.9e-29 101.5 0.1 6.2e-29 100.9 0.1 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Myb_DNA-bind_3 PF12776.2 EDK37640.2 - 0.16 12.6 6.1 7.7 7.2 0.1 2.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Aldo_ket_red PF00248.16 EDK37641.2 - 5.6e-53 179.5 0.0 6.4e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 EDK37642.2 - 5.3e-41 140.3 0.0 6e-41 140.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F_bP_aldolase PF01116.15 EDK37642.2 - 0.003 16.7 0.0 0.0048 16.0 0.0 1.4 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Zn_clus PF00172.13 EDK37643.2 - 5.7e-06 26.1 12.6 5.7e-06 26.1 8.7 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Uds1 PF15456.1 EDK37643.2 - 0.019 14.9 3.3 0.037 14.0 0.7 2.5 2 0 0 2 2 2 0 Up-regulated During Septation Fungal_trans PF04082.13 EDK37644.2 - 1.5e-15 56.8 0.0 3.6e-15 55.5 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK37644.2 - 6.4e-08 32.3 10.1 1.2e-07 31.5 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4214 PF13946.1 EDK37644.2 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) ABC2_membrane PF01061.19 EDK37645.2 - 4.6e-42 143.5 22.8 4.6e-42 143.5 15.8 1.8 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.7 EDK37645.2 - 0.00067 19.2 0.1 0.003 17.1 0.1 2.2 1 0 0 1 1 1 1 CDR ABC transporter Carn_acyltransf PF00755.15 EDK37645.2 - 0.18 9.8 1.6 0.26 9.3 1.1 1.1 1 0 0 1 1 1 0 Choline/Carnitine o-acyltransferase ABC2_membrane_3 PF12698.2 EDK37645.2 - 6.6 5.6 24.3 2.4 7.0 13.4 2.4 1 1 1 2 2 2 0 ABC-2 family transporter protein PDR_CDR PF06422.7 EDK37646.2 - 7.7e-34 115.4 0.1 1.4e-33 114.6 0.1 1.3 1 0 0 1 1 1 1 CDR ABC transporter ABC_tran PF00005.22 EDK37646.2 - 1.1e-18 67.8 0.0 2.1e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.11 EDK37646.2 - 2.1e-06 26.9 0.0 3.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 EDK37646.2 - 3.5e-05 23.3 0.0 6.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC2_membrane PF01061.19 EDK37646.2 - 4.2e-05 22.8 0.8 4.2e-05 22.8 0.5 1.6 2 0 0 2 2 2 1 ABC-2 type transporter AAA_16 PF13191.1 EDK37646.2 - 0.00024 21.1 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 EDK37646.2 - 0.0022 17.9 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK37646.2 - 0.0064 15.9 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EDK37646.2 - 0.0066 15.5 0.0 0.02 13.9 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.1 EDK37646.2 - 0.013 15.4 0.2 0.31 10.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain cobW PF02492.14 EDK37646.2 - 0.018 14.4 0.2 0.032 13.6 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 EDK37646.2 - 0.037 13.7 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 EDK37646.2 - 0.04 14.2 1.6 0.051 13.8 0.1 1.9 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 EDK37646.2 - 0.051 13.5 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 EDK37646.2 - 0.083 13.0 0.1 0.17 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain UPF0079 PF02367.12 EDK37646.2 - 0.099 12.2 0.4 0.28 10.8 0.1 1.8 1 1 1 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ABC_ATPase PF09818.4 EDK37646.2 - 0.11 11.0 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class NACHT PF05729.7 EDK37646.2 - 0.13 11.9 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.1 EDK37646.2 - 0.14 13.0 0.0 0.32 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK37646.2 - 0.2 11.1 0.3 0.35 10.3 0.2 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC2_membrane PF01061.19 EDK37647.2 - 3.2e-10 39.5 2.1 3.9e-10 39.2 1.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter RgpF PF05045.7 EDK37647.2 - 0.063 11.7 0.1 0.075 11.5 0.1 1.1 1 0 0 1 1 1 0 Rhamnan synthesis protein F ABC_tran PF00005.22 EDK37648.2 - 6.6e-14 52.3 0.0 8.7e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_19 PF13245.1 EDK37648.2 - 0.0023 17.6 0.0 0.0035 17.0 0.0 1.3 1 1 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 EDK37648.2 - 0.0044 16.4 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 EDK37648.2 - 0.042 14.1 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EDK37648.2 - 0.085 12.2 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 EDK37648.2 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PQ-loop PF04193.9 EDK37649.2 - 1.9e-42 142.6 14.6 3.8e-22 77.5 1.2 2.9 2 0 0 2 2 2 2 PQ loop repeat DUF3816 PF12822.2 EDK37649.2 - 1.9 8.3 9.9 61 3.4 6.9 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) AMP-binding PF00501.23 EDK37650.2 - 2.9e-62 210.4 0.0 9.1e-61 205.4 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme tRNA_int_end_N2 PF12928.2 EDK37651.2 - 3.4e-21 74.4 0.1 6.9e-21 73.4 0.1 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Smg4_UPF3 PF03467.10 EDK37654.2 - 2.2e-08 34.3 9.2 6.3e-08 32.8 6.4 1.8 1 1 0 1 1 1 1 Smg-4/UPF3 family DUF605 PF04652.11 EDK37654.2 - 2.4 7.4 38.6 3.2 7.0 26.7 1.3 1 0 0 1 1 1 0 Vta1 like PCI PF01399.22 EDK37655.2 - 2.8e-05 24.3 0.1 9e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 PCI domain Cbl_N PF02262.11 EDK37655.2 - 0.029 14.1 0.3 0.44 10.2 0.0 2.6 2 1 1 3 3 3 0 CBL proto-oncogene N-terminal domain 1 F-box-like PF12937.2 EDK37656.2 - 0.038 13.7 0.0 0.094 12.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like Ferric_reduct PF01794.14 EDK37658.2 - 7.2e-15 55.1 10.3 2e-14 53.7 6.8 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component zf-CCHC PF00098.18 EDK37659.2 - 2.2e-07 30.4 30.7 0.00089 19.0 1.4 4.9 4 1 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.1 EDK37659.2 - 0.47 10.1 29.9 1 9.0 1.1 5.3 5 0 0 5 5 5 0 Zinc knuckle Ndc1_Nup PF09531.5 EDK37659.2 - 3.9 5.7 5.4 5.4 5.3 0.3 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Cg6151-P PF10233.4 EDK37660.2 - 1.4e-43 147.4 12.9 1.7e-43 147.1 9.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P COPI_assoc PF08507.5 EDK37660.2 - 0.00056 19.6 6.8 0.00082 19.0 4.7 1.3 1 0 0 1 1 1 1 COPI associated protein YtpI PF14007.1 EDK37660.2 - 0.056 13.3 0.5 0.056 13.3 0.4 2.7 2 1 1 3 3 3 0 YtpI-like protein YwiC PF14256.1 EDK37660.2 - 0.058 13.4 3.3 2.9 7.9 0.1 2.1 2 0 0 2 2 2 0 YwiC-like protein DUF4158 PF13700.1 EDK37660.2 - 0.13 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) Clc-like PF07062.7 EDK37660.2 - 0.28 10.4 8.1 0.6 9.3 5.6 1.5 1 1 0 1 1 1 0 Clc-like MMR_HSR1_C PF08438.5 EDK37661.2 - 6.9e-31 106.7 0.0 1.2e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 EDK37661.2 - 1.6e-17 63.5 0.0 3.4e-17 62.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK37661.2 - 6e-10 38.6 0.4 1.6e-07 30.7 0.0 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 EDK37661.2 - 0.0013 18.1 0.5 0.25 10.7 0.0 2.8 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 EDK37661.2 - 0.003 17.4 0.1 0.016 15.0 0.0 2.1 2 0 0 2 2 2 1 Dynamin family ABC_tran PF00005.22 EDK37661.2 - 0.011 16.0 0.0 0.097 12.9 0.0 2.3 3 0 0 3 3 3 0 ABC transporter AAA_16 PF13191.1 EDK37661.2 - 0.014 15.3 0.1 0.42 10.5 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 EDK37661.2 - 0.015 14.8 0.0 0.039 13.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.1 EDK37661.2 - 0.024 14.5 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 EDK37661.2 - 0.031 13.8 0.3 2.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 EDK37661.2 - 0.044 13.2 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 EDK37661.2 - 0.064 14.0 0.1 0.23 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 EDK37661.2 - 0.067 11.9 0.1 0.23 10.1 0.0 1.9 2 0 0 2 2 2 0 ArgK protein AAA_18 PF13238.1 EDK37661.2 - 0.1 12.9 0.3 1.3 9.3 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.1 EDK37661.2 - 0.12 12.2 0.0 0.87 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EDK37661.2 - 0.19 10.8 0.0 0.36 9.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin CRAL_TRIO PF00650.15 EDK37662.2 - 4.2e-20 71.8 0.0 1e-19 70.5 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain Prok_Ub PF14454.1 EDK37662.2 - 0.0025 17.4 0.0 0.0051 16.4 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic Ubiquitin CRAL_TRIO_N PF03765.10 EDK37662.2 - 0.014 15.4 0.1 0.2 11.8 0.0 2.7 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain DUF3877 PF12993.2 EDK37662.2 - 0.03 13.8 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) DnaJ PF00226.26 EDK37663.2 - 6.2e-22 77.0 2.6 6.2e-22 77.0 1.8 2.6 2 0 0 2 2 2 1 DnaJ domain PigN PF04987.9 EDK37664.2 - 2.5e-84 283.4 23.0 3.5e-84 282.9 16.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 EDK37664.2 - 1.1e-12 47.9 0.0 1.6e-09 37.6 0.0 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EDK37664.2 - 2.1e-08 33.6 0.0 8.1e-08 31.8 0.0 1.9 1 1 1 2 2 2 1 Sulfatase Metalloenzyme PF01676.13 EDK37664.2 - 1.3e-05 24.7 0.0 2.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily IGPS PF00218.16 EDK37665.2 - 9.6e-75 250.9 0.0 1.3e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 EDK37665.2 - 7.3e-46 156.0 0.0 1.1e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EDK37665.2 - 9.5e-09 35.0 0.0 1.9e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 Rep_fac-A_3 PF08661.6 EDK37666.2 - 1.1e-22 79.9 0.1 1.3e-22 79.7 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1_2 PF15490.1 EDK37666.2 - 3.7e-05 23.2 0.0 5.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Pectate_lyase PF03211.8 EDK37666.2 - 0.074 12.4 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Pectate lyase PFU PF09070.6 EDK37667.2 - 5.1e-40 136.1 0.0 9.7e-40 135.2 0.0 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.6 EDK37667.2 - 7.7e-40 136.3 0.1 9.4e-40 136.0 0.1 1.1 1 0 0 1 1 1 1 PUL domain WD40 PF00400.27 EDK37668.2 - 2.8e-45 150.6 11.1 6.8e-08 32.1 0.3 6.4 6 1 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EDK37668.2 - 0.17 10.6 0.9 1.1 7.8 0.1 2.4 2 1 1 3 3 3 0 Nup133 N terminal like Syja_N PF02383.13 EDK37669.1 - 1.8e-60 204.3 1.0 2.3e-60 204.0 0.7 1.1 1 0 0 1 1 1 1 SacI homology domain MFS_1 PF07690.11 EDK37671.1 - 8.8e-10 37.8 4.3 8.8e-10 37.8 3.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK37672.1 - 9.7e-16 57.4 19.2 1.4e-15 56.8 13.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK37672.1 - 6.3e-07 28.3 5.4 8.1e-07 27.9 3.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Ribonucleas_3_3 PF14622.1 EDK37673.2 - 1.2e-09 38.1 1.6 2.9e-09 36.9 0.9 1.8 2 0 0 2 2 2 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 EDK37673.2 - 7.3e-06 26.4 1.7 1.3e-05 25.6 0.2 2.2 2 0 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.20 EDK37673.2 - 0.0042 17.6 0.0 0.18 12.4 0.0 2.4 2 0 0 2 2 2 1 Double-stranded RNA binding motif Mito_carr PF00153.22 EDK37674.1 - 1.1e-45 153.2 8.9 1.5e-18 66.2 0.5 3.2 2 1 0 3 3 3 3 Mitochondrial carrier protein RNA_polI_A34 PF08208.6 EDK37676.2 - 5.8e-56 189.3 27.8 7.7e-56 188.9 19.3 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 GAGA_bind PF06217.7 EDK37676.2 - 0.062 13.2 11.5 0.07 13.0 8.0 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Zip PF02535.17 EDK37676.2 - 0.29 10.0 6.7 0.34 9.8 4.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MIP-T3 PF10243.4 EDK37676.2 - 0.52 8.7 32.2 0.72 8.2 22.3 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.6 EDK37676.2 - 1.1 8.6 24.6 2 7.7 17.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CT47 PF15623.1 EDK37676.2 - 1.7 8.3 17.2 2.8 7.6 11.9 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 DUF2201_N PF13203.1 EDK37676.2 - 7.5 5.6 10.9 10 5.1 7.5 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain CDC45 PF02724.9 EDK37676.2 - 8.3 4.3 15.7 12 3.7 10.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.5 EDK37677.2 - 2.3 6.5 7.0 3.7 5.8 4.9 1.4 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Methyltransf_6 PF03737.10 EDK37678.2 - 1.1e-23 83.8 0.1 1.6e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase SHS2_FTSA PF02491.15 EDK37678.2 - 0.08 12.8 0.8 0.24 11.3 0.4 1.8 1 1 1 2 2 2 0 SHS2 domain inserted in FTSA Pkinase PF00069.20 EDK37680.2 - 3.2e-69 232.9 0.0 4.1e-69 232.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37680.2 - 1.3e-39 135.8 0.0 1.8e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK37680.2 - 2.6e-05 23.3 0.0 4.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK37680.2 - 0.066 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EDK37681.2 - 7.5e-36 123.6 0.0 1.7e-35 122.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37681.2 - 4.8e-14 52.0 0.0 9.9e-14 51.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EDK37681.2 - 0.11 11.5 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Atrophin-1 PF03154.10 EDK37681.2 - 4.5 5.2 8.7 6 4.8 6.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family Pkinase PF00069.20 EDK37682.2 - 3.5e-68 229.5 0.3 5.6e-68 228.8 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37682.2 - 4e-52 176.8 0.1 6.1e-52 176.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 EDK37682.2 - 4.6e-22 78.2 3.7 1.8e-21 76.3 0.2 2.9 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 EDK37682.2 - 8.3e-09 34.8 0.0 1.6e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PH PF00169.24 EDK37682.2 - 1.2e-07 31.8 0.1 3.6e-07 30.3 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 EDK37682.2 - 0.0001 22.4 0.2 0.00029 20.9 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.1 EDK37682.2 - 0.0016 18.6 0.0 0.0098 16.1 0.0 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain APH PF01636.18 EDK37682.2 - 0.0027 17.4 0.1 0.012 15.4 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EDK37682.2 - 0.0047 15.7 0.2 0.0094 14.8 0.1 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Gti1_Pac2 PF09729.4 EDK37683.2 - 1.7e-52 177.7 0.2 1.7e-52 177.7 0.1 2.0 2 1 0 2 2 2 1 Gti1/Pac2 family F-box-like PF12937.2 EDK37684.2 - 2.2e-07 30.5 0.2 2.2e-07 30.5 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EDK37684.2 - 8.9e-06 25.2 3.1 1.7e-05 24.3 0.5 2.6 2 0 0 2 2 2 1 F-box domain Condensin2nSMC PF12422.3 EDK37684.2 - 0.015 14.9 0.2 7.6 6.2 0.0 2.7 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit TFIIE_beta PF02186.10 EDK37685.2 - 3e-27 94.3 0.4 5.9e-27 93.4 0.3 1.5 1 0 0 1 1 1 1 TFIIE beta subunit core domain Mt_ATP-synt_D PF05873.7 EDK37685.2 - 0.00056 19.5 0.1 0.0011 18.6 0.1 1.5 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) NTF2 PF02136.15 EDK37686.1 - 6.3e-24 84.6 0.0 6.9e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF1840 PF08895.6 EDK37687.2 - 0.42 10.6 5.1 2.7 8.0 0.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) cwf21 PF08312.7 EDK37688.2 - 1e-13 50.8 7.7 2.7e-13 49.5 2.6 2.5 2 0 0 2 2 2 1 cwf21 domain Prog_receptor PF02161.10 EDK37688.2 - 0.13 11.0 2.6 0.13 11.0 1.8 1.2 1 0 0 1 1 1 0 Progesterone receptor FHIPEP PF00771.15 EDK37688.2 - 0.82 7.9 2.5 0.99 7.6 1.7 1.0 1 0 0 1 1 1 0 FHIPEP family Mannosyl_trans3 PF11051.3 EDK37689.2 - 2.9e-85 285.8 0.0 4.2e-85 285.3 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative O-antigen_lig PF13425.1 EDK37689.2 - 0.023 14.6 0.1 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Wzy_C PF04932.10 EDK37689.2 - 0.074 12.8 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 O-Antigen ligase Aldo_ket_red PF00248.16 EDK37690.2 - 2.4e-41 141.4 0.0 2.8e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family GntR PF00392.16 EDK37690.2 - 0.012 15.0 0.0 1.4 8.4 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Maf1 PF09174.5 EDK37691.2 - 1.7e-31 109.4 5.0 7e-22 78.1 0.1 2.5 2 0 0 2 2 2 2 Maf1 regulator Rad51 PF08423.6 EDK37692.2 - 2.3e-20 72.5 0.1 1e-15 57.3 0.0 2.2 2 0 0 2 2 2 2 Rad51 KaiC PF06745.8 EDK37692.2 - 1.2e-09 37.6 1.5 5.3e-09 35.5 0.3 2.6 2 1 0 2 2 2 1 KaiC AAA_25 PF13481.1 EDK37692.2 - 6.7e-09 35.4 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EDK37692.2 - 0.0023 17.0 0.0 0.0036 16.4 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATP-synt_ab PF00006.20 EDK37692.2 - 0.012 15.1 0.0 0.038 13.4 0.0 2.1 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Bac_DnaA PF00308.13 EDK37692.2 - 0.016 14.8 0.1 2.9 7.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein Arch_ATPase PF01637.13 EDK37692.2 - 0.018 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase ABC_tran PF00005.22 EDK37692.2 - 0.02 15.1 0.1 0.26 11.5 0.0 2.5 2 0 0 2 2 2 0 ABC transporter PAXNEB PF05625.6 EDK37692.2 - 0.04 12.7 1.7 0.085 11.6 0.2 1.9 1 1 1 2 2 2 0 PAXNEB protein PhoH PF02562.11 EDK37692.2 - 0.043 13.0 0.0 0.078 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Pyr_redox_2 PF07992.9 EDK37693.2 - 1.9e-07 31.1 0.0 4.9e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK37693.2 - 1.9e-05 24.9 0.1 3.3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK37693.2 - 0.012 14.5 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.1 EDK37693.2 - 0.057 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase YceI PF04264.8 EDK37693.2 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 YceI-like domain Pyrophosphatase PF00719.14 EDK37694.2 - 3.3e-53 179.3 0.2 4.3e-53 178.9 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase TP6A_N PF04406.9 EDK37695.2 - 4.6e-12 45.4 0.6 1.1e-11 44.1 0.4 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.5 EDK37695.2 - 0.076 12.8 0.0 0.19 11.5 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) RCR PF12273.3 EDK37696.1 - 4.2e-43 147.0 9.8 1.9e-42 144.9 6.8 2.0 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF2167 PF09935.4 EDK37696.1 - 0.038 12.8 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) DUF221 PF02714.10 EDK37697.2 - 3.1e-101 338.4 20.1 3.1e-101 338.4 13.9 2.4 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EDK37697.2 - 1.2e-42 145.1 1.4 1.2e-42 145.1 0.9 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EDK37697.2 - 4.9e-28 96.8 0.2 2.5e-27 94.5 0.2 2.1 2 0 0 2 2 2 1 Phosphate metabolism protein DUF4463 PF14703.1 EDK37697.2 - 6.2e-16 58.6 4.2 1.5e-15 57.5 2.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) TMEM154 PF15102.1 EDK37697.2 - 0.043 13.5 3.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 TMEM154 protein family HMGL-like PF00682.14 EDK37699.1 - 8.2e-63 212.2 0.0 1.2e-62 211.6 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 EDK37699.1 - 7.9e-26 90.4 0.0 1.4e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Sugar_tr PF00083.19 EDK37700.2 - 7.4e-51 173.1 23.5 9.8e-51 172.7 16.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37700.2 - 7.3e-19 67.6 52.6 1.2e-15 57.1 20.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF606 PF04657.8 EDK37700.2 - 0.00029 20.9 1.8 0.00029 20.9 1.2 4.0 3 2 1 4 4 4 2 Protein of unknown function, DUF606 Syja_N PF02383.13 EDK37701.2 - 1.2e-64 218.0 0.1 2.2e-64 217.2 0.1 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 EDK37701.2 - 4.7e-24 85.6 0.0 8.9e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-HC2 PF13490.1 EDK37701.2 - 0.068 13.1 0.0 0.41 10.6 0.0 2.3 2 0 0 2 2 2 0 Putative zinc-finger DUF3992 PF13157.1 EDK37702.1 - 0.033 14.3 0.2 0.074 13.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) Trm112p PF03966.11 EDK37704.1 - 1.5e-19 70.1 0.0 2.1e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.1 EDK37704.1 - 0.088 13.0 0.4 0.088 13.0 0.3 1.6 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-NADH-PPase PF09297.6 EDK37704.1 - 0.098 12.1 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain Pkinase PF00069.20 EDK37705.2 - 2.1e-71 240.1 0.4 5.3e-71 238.8 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37705.2 - 1.4e-31 109.5 0.1 6.6e-23 81.1 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EDK37705.2 - 3.7e-07 29.3 0.3 0.071 12.0 0.0 3.1 2 1 0 3 3 3 2 Kinase-like Kdo PF06293.9 EDK37705.2 - 0.022 13.8 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HPIP PF15226.1 EDK37705.2 - 0.027 14.5 0.0 0.078 13.0 0.0 1.8 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family QLQ PF08880.6 EDK37705.2 - 8.4 5.9 5.8 0.95 8.9 1.0 1.7 2 0 0 2 2 2 0 QLQ PIR PF00399.14 EDK37706.1 - 4.4e-11 41.6 74.3 3.2e-05 23.0 2.7 7.2 6 1 1 7 7 7 6 Yeast PIR protein repeat Med3 PF11593.3 EDK37706.1 - 2.4 7.3 11.3 3.1 6.9 7.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Glyco_transf_41 PF13844.1 EDK37706.1 - 3.9 5.3 6.5 1.9 6.3 2.9 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 41 zf-C2H2 PF00096.21 EDK37707.2 - 1.5e-08 34.5 15.1 0.00012 22.1 1.2 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37707.2 - 1.3e-05 25.2 13.9 0.00021 21.3 0.6 3.5 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.2 EDK37707.2 - 0.00023 21.2 0.5 0.00023 21.2 0.4 2.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EDK37707.2 - 0.0015 18.6 0.4 0.0015 18.6 0.3 3.2 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 EDK37707.2 - 0.0055 16.9 13.5 0.0061 16.7 0.4 3.9 4 0 0 4 4 4 2 Zinc-finger double domain TerY-C PF15616.1 EDK37707.2 - 0.025 14.5 1.0 0.045 13.6 0.7 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-Di19 PF05605.7 EDK37707.2 - 0.17 12.0 2.9 33 4.7 0.1 2.3 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.1 EDK37707.2 - 0.18 11.5 6.2 3 7.6 0.4 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Ank_2 PF12796.2 EDK37708.2 - 9.3e-18 64.3 0.1 3.9e-12 46.3 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK37708.2 - 1.7e-12 47.4 2.1 7.3e-08 32.7 0.1 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 EDK37708.2 - 6.7e-11 41.4 1.8 0.0027 17.4 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 EDK37708.2 - 4.3e-09 36.3 1.6 0.021 15.0 0.0 4.1 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK37708.2 - 2.8e-06 27.0 6.6 0.79 10.1 0.0 5.4 6 0 0 6 6 6 3 Ankyrin repeat MutS_V PF00488.16 EDK37709.2 - 2.4e-81 272.5 0.0 4.6e-81 271.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EDK37709.2 - 2.5e-35 122.1 0.5 1.3e-34 119.8 0.2 2.3 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.15 EDK37709.2 - 2.4e-28 98.4 0.0 1.1e-27 96.2 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.12 EDK37709.2 - 4.9e-06 26.6 0.2 3.1e-05 24.0 0.0 2.6 2 1 0 2 2 2 1 MutS domain II AAA_14 PF13173.1 EDK37709.2 - 0.016 15.1 0.0 0.083 12.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain MtrG PF04210.8 EDK37709.2 - 0.027 14.1 0.0 0.079 12.6 0.0 1.8 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Abhydrolase_6 PF12697.2 EDK37710.2 - 5.8e-22 78.6 0.0 8.8e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK37710.2 - 2.1e-12 47.0 0.0 3.1e-11 43.2 0.0 2.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK37710.2 - 6.7e-06 25.9 0.0 2.3e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 EDK37710.2 - 0.00013 21.1 0.2 0.00029 20.0 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DUF2305 PF10230.4 EDK37710.2 - 0.0003 20.2 0.0 0.0012 18.3 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2305) Hydrolase_4 PF12146.3 EDK37710.2 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Lipase_3 PF01764.20 EDK37710.2 - 0.023 14.3 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.7 EDK37710.2 - 0.088 12.1 0.0 0.5 9.6 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Pmp3 PF01679.12 EDK37712.1 - 1.1e-19 69.7 4.2 1.6e-19 69.2 2.9 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Antimicrobial10 PF08105.6 EDK37712.1 - 0.25 10.9 2.3 0.49 10.0 1.6 1.5 1 0 0 1 1 1 0 Metchnikowin family TUG-UBL1 PF11470.3 EDK37713.2 - 1e-19 70.2 0.2 2.3e-19 69.0 0.1 1.7 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 EDK37713.2 - 0.011 15.7 0.1 0.061 13.3 0.0 2.3 2 1 0 2 2 2 0 UBX domain ubiquitin PF00240.18 EDK37713.2 - 0.12 11.7 1.3 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family bZIP_1 PF00170.16 EDK37714.2 - 9.8e-14 51.0 8.4 2e-13 50.0 5.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EDK37714.2 - 1.4e-09 37.5 5.6 2.8e-09 36.6 3.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 EDK37714.2 - 0.011 15.9 4.6 0.011 15.9 3.2 1.7 2 0 0 2 2 2 0 bZIP Maf transcription factor Ten1 PF12658.2 EDK37714.2 - 0.1 12.3 1.0 2.4 7.9 0.0 2.5 2 1 1 3 3 3 0 Telomere capping, CST complex subunit HeH PF12949.2 EDK37714.2 - 0.12 11.9 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain DUF4613 PF15390.1 EDK37714.2 - 0.32 9.1 5.9 0.44 8.6 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) RRM_1 PF00076.17 EDK37715.2 - 2.6e-15 55.7 1.9 1.3e-10 40.7 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37715.2 - 1.1e-10 41.2 0.3 2.7e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37715.2 - 5.6e-10 38.9 0.6 2.2e-09 36.9 0.2 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Draxin PF15550.1 EDK37715.2 - 0.039 13.5 0.3 0.048 13.3 0.2 1.1 1 0 0 1 1 1 0 Draxin VIT1 PF01988.14 EDK37716.2 - 7.1e-61 205.3 3.4 9.4e-61 204.9 2.3 1.2 1 0 0 1 1 1 1 VIT family Cad PF03596.8 EDK37716.2 - 0.036 13.7 0.3 0.063 12.9 0.2 1.3 1 0 0 1 1 1 0 Cadmium resistance transporter FIST PF08495.5 EDK37716.2 - 0.078 12.1 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 FIST N domain Band_7 PF01145.20 EDK37717.2 - 4.7e-26 91.7 4.1 7.6e-26 91.1 2.8 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2884 PF11101.3 EDK37717.2 - 0.0067 15.8 1.2 0.011 15.0 0.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2884) GatB_Yqey PF02637.13 EDK37717.2 - 0.032 13.9 0.8 0.058 13.0 0.5 1.4 1 0 0 1 1 1 0 GatB domain Peptidase_M24 PF00557.19 EDK37718.2 - 9.8e-53 178.8 0.0 1.4e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 EDK37718.2 - 4.3e-30 103.8 0.0 8.9e-30 102.8 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Zein-binding PF04576.10 EDK37718.2 - 0.065 13.3 0.6 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Zein-binding Peptidase_C48 PF02902.14 EDK37719.2 - 1.2e-09 38.0 2.5 5.8e-09 35.8 1.8 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C5 PF00770.13 EDK37719.2 - 0.028 13.9 0.0 0.052 13.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus endoprotease Tmemb_170 PF10190.4 EDK37721.2 - 0.041 13.9 8.9 0.065 13.2 6.2 1.3 1 0 0 1 1 1 0 Putative transmembrane protein 170 Proteasome PF00227.21 EDK37722.2 - 8.7e-60 201.2 0.2 1.1e-59 200.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EDK37722.2 - 8.1e-14 50.6 0.4 1.4e-13 49.9 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature NCA2 PF08637.5 EDK37723.2 - 2.4e-83 279.3 2.1 2.4e-83 279.3 1.5 1.7 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 zf-C2H2 PF00096.21 EDK37724.2 - 9.7e-11 41.3 8.6 1.7e-05 24.8 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37724.2 - 1.1e-07 31.6 9.3 0.0018 18.4 0.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK37724.2 - 1.7e-05 24.9 10.0 0.0016 18.6 1.2 3.2 3 0 0 3 3 3 2 Zinc-finger double domain Sporozoite_P67 PF05642.6 EDK37724.2 - 0.0015 16.4 0.4 0.0015 16.4 0.3 1.9 2 0 0 2 2 2 1 Sporozoite P67 surface antigen DASH_Spc19 PF08287.6 EDK37724.2 - 0.0043 16.6 0.5 0.0072 15.9 0.3 1.3 1 0 0 1 1 1 1 Spc19 zf-C2H2_6 PF13912.1 EDK37724.2 - 0.012 15.5 6.7 0.42 10.5 0.7 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-CHY PF05495.7 EDK37724.2 - 0.018 15.2 1.0 0.032 14.3 0.7 1.4 1 0 0 1 1 1 0 CHY zinc finger zf-C2H2_jaz PF12171.3 EDK37724.2 - 0.019 15.0 5.9 0.42 10.8 0.7 2.6 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK37724.2 - 0.025 14.7 1.1 3.3 8.0 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type KRTDAP PF15200.1 EDK37724.2 - 0.028 14.1 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Keratinocyte differentiation-associated RXT2_N PF08595.6 EDK37724.2 - 0.029 14.1 0.9 0.047 13.4 0.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Med3 PF11593.3 EDK37724.2 - 0.034 13.3 1.6 0.046 12.9 1.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-Di19 PF05605.7 EDK37724.2 - 0.034 14.2 0.6 0.068 13.3 0.4 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met2 PF12907.2 EDK37724.2 - 0.11 12.5 5.5 7.9 6.5 3.6 2.4 1 1 1 2 2 2 0 Zinc-binding DUF3402 PF11882.3 EDK37724.2 - 0.16 10.9 1.2 0.23 10.4 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DUF2256 PF10013.4 EDK37724.2 - 0.23 11.2 1.1 7.8 6.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) PBP1_TM PF14812.1 EDK37724.2 - 1.9 8.8 6.2 5.1 7.4 4.3 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.8 EDK37724.2 - 3.8 5.1 7.4 5.2 4.7 5.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi WW PF00397.21 EDK37725.2 - 0.00019 21.2 1.1 0.00049 19.9 0.8 1.8 1 0 0 1 1 1 1 WW domain MbeB_N PF04837.7 EDK37725.2 - 6 7.0 6.3 19 5.4 0.8 3.0 3 0 0 3 3 3 0 MbeB-like, N-term conserved region ketoacyl-synt PF00109.21 EDK37726.2 - 2.8e-57 194.1 0.3 2.8e-57 194.1 0.2 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 EDK37726.2 - 8.9e-34 115.8 1.3 1.6e-33 115.0 0.9 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 EDK37726.2 - 1.8e-05 23.8 0.0 3.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain SKN1 PF03935.10 EDK37727.2 - 2.7e-252 837.3 7.0 3.3e-252 837.0 4.8 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) APG9 PF04109.11 EDK37728.2 - 6.4e-162 538.6 10.2 8.2e-162 538.2 7.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Tetraspannin PF00335.15 EDK37728.2 - 1.6 7.9 9.8 4 6.6 1.9 3.5 3 0 0 3 3 3 0 Tetraspanin family Nop14 PF04147.7 EDK37729.2 - 6.3e-222 738.9 63.0 1.6e-136 456.4 12.9 2.4 1 1 1 2 2 2 2 Nop14-like family MARVEL PF01284.18 EDK37730.2 - 2.1e-30 105.4 18.5 2.5e-30 105.1 12.8 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.7 EDK37730.2 - 0.044 13.3 13.3 0.035 13.6 7.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF588) Tetraspannin PF00335.15 EDK37730.2 - 0.89 8.7 19.9 0.037 13.3 8.0 2.0 1 1 1 2 2 2 0 Tetraspanin family Ank_2 PF12796.2 EDK37731.2 - 3.2e-46 155.5 0.9 2e-21 76.0 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK37731.2 - 1.3e-37 127.4 1.0 2.9e-11 43.5 0.1 5.3 4 2 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 EDK37731.2 - 3.4e-35 118.0 2.0 2e-06 27.3 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 EDK37731.2 - 7.9e-34 114.9 0.8 1.4e-10 41.0 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK37731.2 - 7e-28 93.9 0.0 3.7e-05 23.5 0.0 6.6 7 0 0 7 7 7 5 Ankyrin repeat Sugar_tr PF00083.19 EDK37732.2 - 3.5e-118 395.0 27.9 4e-118 394.8 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37732.2 - 1.6e-13 50.1 34.3 2.8e-13 49.3 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SecE PF00584.15 EDK37732.2 - 0.056 13.0 0.0 0.34 10.5 0.0 2.4 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Prenyltransf PF01255.14 EDK37733.2 - 3.7e-05 22.9 0.0 0.00014 21.0 0.0 1.8 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase DUF3284 PF11687.3 EDK37735.2 - 0.0081 15.8 0.1 0.017 14.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3284) zf-met PF12874.2 EDK37735.2 - 1.3 9.3 4.8 7.8 6.8 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type IPPT PF01715.12 EDK37736.2 - 2.1e-68 230.0 0.0 2.6e-68 229.7 0.0 1.0 1 0 0 1 1 1 1 IPP transferase Arginase PF00491.16 EDK37736.2 - 0.13 11.5 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Arginase family BRO1 PF03097.13 EDK37737.2 - 5.5e-88 295.2 3.0 5.5e-88 295.2 2.1 2.1 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 EDK37737.2 - 6.2e-67 225.6 9.3 6.2e-67 225.6 6.5 1.8 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Myb_DNA-bind_6 PF13921.1 EDK37738.2 - 1.9e-20 72.7 3.4 2.9e-12 46.4 1.3 3.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EDK37738.2 - 1.5e-19 69.7 2.4 7.9e-09 35.4 0.2 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.3 EDK37738.2 - 0.0091 15.8 2.6 0.52 10.2 0.1 3.0 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF1690 PF07956.6 EDK37739.2 - 0.85 9.5 7.6 5.2 7.0 0.2 3.1 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) RRP7 PF12923.2 EDK37740.1 - 0.35 10.8 3.6 0.34 10.9 0.4 2.0 1 1 1 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) DUF2962 PF11176.3 EDK37741.2 - 1.6e-54 183.6 7.0 1.8e-54 183.5 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) DUF4589 PF15252.1 EDK37741.2 - 0.038 13.7 0.1 0.091 12.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4589) Antimicrobial_2 PF08023.7 EDK37741.2 - 0.068 13.4 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Frog antimicrobial peptide DUF87 PF01935.12 EDK37741.2 - 0.097 12.4 2.0 0.15 11.8 1.4 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF87 DUF1053 PF06327.9 EDK37741.2 - 1.4 9.2 5.2 1.1 9.5 2.4 1.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) Mating_N PF12731.2 EDK37742.2 - 0.024 14.5 1.5 0.12 12.2 0.1 2.9 2 0 0 2 2 2 0 Mating-type protein beta 1 RGS PF00615.14 EDK37743.2 - 3.9e-07 30.1 0.2 0.00049 20.1 0.0 2.4 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF619 PF04768.8 EDK37745.2 - 2e-50 170.5 1.2 4.5e-50 169.3 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 EDK37745.2 - 7e-31 107.0 0.0 1.7e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 EDK37745.2 - 1.4e-21 77.1 0.0 2.5e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.13 EDK37745.2 - 1.4e-08 34.7 0.0 4.1e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.15 EDK37745.2 - 0.0039 17.0 0.0 0.011 15.6 0.0 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Hydrolase_3 PF08282.7 EDK37745.2 - 0.031 13.8 0.1 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Y_phosphatase2 PF03162.8 EDK37746.2 - 9.8e-31 106.3 0.2 2.3e-29 101.8 0.2 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Mso1_C PF14477.1 EDK37747.2 - 2.2e-23 82.3 14.1 2.2e-23 82.3 9.7 2.7 3 1 0 3 3 3 1 Membrane-polarising domain of Mso1 Mso1_Sec1_bdg PF14475.1 EDK37747.2 - 1.4e-18 66.0 0.1 3.1e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Sec1-binding region of Mso1 eIF-3c_N PF05470.7 EDK37747.2 - 0.2 9.6 2.7 0.23 9.5 1.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Macoilin PF09726.4 EDK37747.2 - 0.84 7.8 9.8 0.87 7.7 6.8 1.1 1 0 0 1 1 1 0 Transmembrane protein SRP-alpha_N PF04086.8 EDK37747.2 - 2.1 7.6 10.5 5 6.4 7.3 1.7 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DEAD PF00270.24 EDK37748.2 - 6.9e-35 120.0 0.2 5.9e-34 116.9 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK37748.2 - 2.5e-23 81.7 0.2 5.1e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK37748.2 - 5.1e-08 32.9 0.1 2.7e-07 30.5 0.1 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EDK37748.2 - 0.011 15.5 0.1 0.034 13.8 0.1 1.8 1 0 0 1 1 1 0 Part of AAA domain SecA_DEAD PF07517.9 EDK37748.2 - 0.023 14.0 0.0 0.047 12.9 0.0 1.5 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_30 PF13604.1 EDK37748.2 - 0.061 12.8 0.5 0.1 12.1 0.3 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EDK37748.2 - 0.082 12.1 0.3 0.14 11.3 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein NAD_binding_10 PF13460.1 EDK37749.2 - 1.3e-05 25.3 0.0 2.3e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding HIM1 PF08732.5 EDK37749.2 - 1.5e-05 23.6 0.0 6.4e-05 21.5 0.0 1.8 1 1 2 3 3 3 1 HIM1 Epimerase PF01370.16 EDK37749.2 - 0.002 17.5 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 EDK37749.2 - 0.011 16.0 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 EDK37749.2 - 0.015 15.8 0.1 0.073 13.6 0.0 2.1 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NmrA PF05368.8 EDK37749.2 - 0.032 13.4 0.1 0.047 12.9 0.1 1.6 1 1 0 1 1 1 0 NmrA-like family Sad1_UNC PF07738.8 EDK37750.2 - 2.7e-37 127.5 0.1 8.2e-37 126.0 0.1 1.9 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.20 EDK37750.2 - 0.0037 17.0 0.0 0.012 15.4 0.0 1.8 1 0 0 1 1 1 1 F5/8 type C domain Muskelin_N PF06588.6 EDK37750.2 - 0.0058 16.3 0.3 0.014 15.1 0.2 1.6 1 0 0 1 1 1 1 Muskelin N-terminus RAI1 PF08652.6 EDK37751.2 - 6.1e-29 99.6 0.0 1.3e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Catalase PF00199.14 EDK37752.1 - 2.8e-179 595.7 1.6 3.7e-179 595.3 1.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EDK37752.1 - 6.8e-12 45.0 1.4 5.6e-11 42.1 0.2 2.9 4 0 0 4 4 4 1 Catalase-related immune-responsive Plasmodium_Vir PF05795.6 EDK37754.2 - 0.9 8.6 3.7 1 8.4 2.5 1.3 1 1 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.4 EDK37754.2 - 5.4 5.5 10.9 6.1 5.3 7.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein RRM_1 PF00076.17 EDK37755.2 - 1.1e-06 28.2 0.1 2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37755.2 - 1.5e-06 27.9 0.0 2.8e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK37755.2 - 0.00021 20.9 0.1 0.00038 20.1 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_6 PF14259.1 EDK37755.2 - 0.0016 18.3 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) AKAP_110 PF05716.8 EDK37755.2 - 0.061 11.3 0.2 0.076 10.9 0.1 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) DEAD PF00270.24 EDK37756.2 - 2.3e-40 137.8 0.1 6.2e-40 136.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK37756.2 - 9.2e-26 89.5 0.2 2.1e-25 88.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK37756.2 - 0.0062 16.3 1.3 0.018 14.8 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PUCC PF03209.10 EDK37757.2 - 0.0005 18.9 2.9 0.00095 17.9 2.0 1.5 1 0 0 1 1 1 1 PUCC protein Nodulin-like PF06813.8 EDK37757.2 - 0.0009 18.5 2.2 0.0009 18.5 1.5 2.3 2 0 0 2 2 2 2 Nodulin-like Aminotran_3 PF00202.16 EDK37758.2 - 1.2e-59 201.9 0.0 1.7e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 EDK37758.2 - 0.0045 16.1 0.0 0.0077 15.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase NAC PF01849.13 EDK37759.1 - 7.9e-16 57.3 0.1 1.4e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 NAC domain DEC-1_N PF04625.8 EDK37759.1 - 0.017 13.8 0.0 0.026 13.2 0.0 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Pyridoxal_deC PF00282.14 EDK37760.2 - 4.2e-53 180.1 0.0 6e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 EDK37760.2 - 1.5e-07 30.4 0.0 2.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DUF1774 PF08611.5 EDK37761.2 - 1.4e-32 111.7 2.7 1.4e-32 111.7 1.9 2.6 3 1 1 4 4 4 1 Fungal protein of unknown function (DUF1774) SF3b10 PF07189.6 EDK37762.1 - 1e-27 95.7 0.0 1.1e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) GATA PF00320.22 EDK37763.2 - 9.9e-16 56.8 4.5 1.9e-15 55.8 3.1 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 EDK37763.2 - 2.1e-08 33.5 0.1 4.3e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.7 EDK37763.2 - 0.0016 17.7 1.7 0.0027 16.9 0.3 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding Elf1 PF05129.8 EDK37763.2 - 0.006 16.2 0.1 0.013 15.2 0.1 1.5 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like DUF2197 PF09963.4 EDK37763.2 - 0.031 14.2 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) Mcm10 PF09332.6 EDK37763.2 - 1.1 8.5 4.2 1.9 7.7 0.4 2.3 2 0 0 2 2 2 0 Mcm10 replication factor ADH_zinc_N PF00107.21 EDK37764.2 - 4.2e-09 36.0 0.0 7.3e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK37764.2 - 6.9e-06 26.9 0.0 4.7e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK37764.2 - 0.00032 20.4 0.0 0.00056 19.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Sel1 PF08238.7 EDK37765.2 - 6.3e-12 45.7 1.3 0.0069 16.9 0.0 7.2 7 1 0 7 7 7 2 Sel1 repeat TPR_11 PF13414.1 EDK37765.2 - 0.00037 20.0 2.3 0.0012 18.4 0.5 2.7 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.1 EDK37765.2 - 0.0018 18.1 0.1 0.02 14.8 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK37765.2 - 0.12 12.3 0.4 1.5 8.9 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Aa_trans PF01490.13 EDK37766.2 - 6.7e-82 275.1 36.6 8e-82 274.8 25.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MitoNEET_N PF10660.4 EDK37766.2 - 1.6 8.6 5.1 6 6.8 0.1 3.3 3 0 0 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus ApoO PF09769.4 EDK37767.2 - 1.6e-40 138.4 0.3 2.3e-39 134.6 0.0 2.0 2 0 0 2 2 2 1 Apolipoprotein O HVSL PF09749.4 EDK37767.2 - 0.054 12.5 0.3 0.29 10.1 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein Syntaxin-6_N PF09177.6 EDK37767.2 - 0.076 13.4 0.1 5.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal ApbA_C PF08546.6 EDK37768.2 - 1.3e-07 31.5 0.0 3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Tropomyosin_1 PF12718.2 EDK37768.2 - 0.0006 19.6 12.8 0.00094 19.0 8.9 1.2 1 0 0 1 1 1 1 Tropomyosin like Reo_sigmaC PF04582.7 EDK37768.2 - 0.02 14.1 1.7 0.16 11.1 0.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 EDK37768.2 - 0.083 10.2 11.7 0.12 9.7 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-Q PF13094.1 EDK37768.2 - 0.26 11.3 15.9 0.086 12.8 8.5 1.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF2968 PF11180.3 EDK37768.2 - 0.29 10.4 9.6 0.58 9.5 6.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Atg14 PF10186.4 EDK37768.2 - 0.31 9.9 12.5 0.54 9.1 8.7 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 EDK37768.2 - 0.38 10.3 14.0 0.67 9.5 9.7 1.3 1 0 0 1 1 1 0 IncA protein TBPIP PF07106.8 EDK37768.2 - 0.62 9.5 13.7 1.2 8.6 9.5 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) V_ATPase_I PF01496.14 EDK37768.2 - 1.3 6.7 6.9 1.9 6.2 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HALZ PF02183.13 EDK37768.2 - 1.6 8.5 9.0 3.4 7.4 0.2 2.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.4 EDK37768.2 - 2.2 8.2 14.2 3.9 7.4 9.9 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.1 EDK37768.2 - 3.2 6.6 4.7 6.7 5.5 3.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6 PF04111.7 EDK37768.2 - 6.7 5.6 16.6 12 4.7 11.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Thymidylate_kin PF02223.12 EDK37769.2 - 7.9e-40 136.2 0.0 9.7e-40 135.9 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.1 EDK37769.2 - 0.0001 22.3 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK37769.2 - 0.00054 20.2 0.0 0.00078 19.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 EDK37769.2 - 0.0052 16.0 0.0 0.01 15.0 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 dNK PF01712.14 EDK37769.2 - 0.08 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase CPT PF07931.7 EDK37769.2 - 0.099 12.2 0.0 0.23 11.0 0.0 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Clat_adaptor_s PF01217.15 EDK37770.2 - 4.8e-51 172.2 2.6 5.6e-51 171.9 1.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ku_N PF03731.10 EDK37771.2 - 6.5e-17 61.7 0.1 1.4e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.11 EDK37771.2 - 3.7e-15 55.8 0.0 2.9e-13 49.7 0.0 2.5 2 1 0 2 2 2 2 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 EDK37771.2 - 0.032 14.7 0.2 0.14 12.7 0.1 2.2 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm Mannosyl_trans3 PF11051.3 EDK37772.2 - 2.8e-55 187.5 0.0 4.5e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative RNA_pol_Rpb8 PF03870.10 EDK37774.1 - 7.1e-45 152.5 0.1 8e-45 152.4 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 DUF4179 PF13786.1 EDK37774.1 - 0.037 14.2 0.1 0.083 13.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) CsgG PF03783.9 EDK37774.1 - 0.12 11.4 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Curli production assembly/transport component CsgG MFS_1 PF07690.11 EDK37775.2 - 2.9e-06 26.2 28.6 5.7e-06 25.2 18.1 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2023 PF09633.5 EDK37775.2 - 0.14 12.1 0.0 28 4.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2023) DUF2462 PF09495.5 EDK37776.1 - 5.3e-24 84.7 10.8 5.3e-24 84.7 7.5 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) GATase_5 PF13507.1 EDK37777.2 - 5e-103 343.5 0.1 8.2e-103 342.8 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 EDK37777.2 - 1.9e-43 148.0 0.4 1.5e-22 80.2 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 EDK37777.2 - 1.3e-25 89.4 0.8 1.1e-24 86.5 0.0 2.8 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain nsp8 PF08717.5 EDK37777.2 - 0.066 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 nsp8 replicase Ribosomal_S3_C PF00189.15 EDK37778.1 - 7.9e-15 54.8 0.1 1.6e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 EDK37778.1 - 9.5e-09 34.7 0.4 1.8e-08 33.8 0.3 1.5 1 0 0 1 1 1 1 KH domain Tmemb_14 PF03647.8 EDK37780.1 - 1.1e-26 92.9 6.1 1.3e-26 92.8 4.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C SNF2_N PF00176.18 EDK37782.2 - 6.3e-73 245.1 1.6 1.2e-72 244.2 1.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.1 EDK37782.2 - 3e-29 101.8 15.1 3e-29 101.8 10.4 2.5 2 0 0 2 2 2 1 DNA-binding domain Helicase_C PF00271.26 EDK37782.2 - 7.1e-14 51.4 0.0 2e-13 49.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK37782.2 - 1.7e-06 27.9 0.1 5e-05 23.2 0.0 3.2 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK37782.2 - 0.00094 18.7 0.0 0.0066 15.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Host_attach PF10116.4 EDK37782.2 - 0.021 15.0 0.0 0.074 13.2 0.0 1.9 1 0 0 1 1 1 0 Protein required for attachment to host cells adh_short PF00106.20 EDK37783.2 - 4e-25 88.6 0.0 5e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK37783.2 - 1.2e-16 61.2 0.0 1.5e-16 60.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK37783.2 - 1.8e-14 53.7 0.0 2.3e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK37783.2 - 5.5e-07 29.7 0.1 9.7e-07 28.9 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 EDK37783.2 - 0.00022 20.4 0.0 0.00035 19.8 0.0 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 EDK37783.2 - 0.00037 20.0 0.0 0.00059 19.3 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 EDK37783.2 - 0.038 12.9 0.3 0.048 12.6 0.2 1.3 1 1 0 1 1 1 0 Saccharopine dehydrogenase Vezatin PF12632.2 EDK37784.2 - 2e-47 161.3 13.3 2e-47 161.3 9.2 2.3 3 0 0 3 3 3 1 Mysoin-binding motif of peroxisomes Cob_adeno_trans PF01923.13 EDK37784.2 - 0.013 15.2 0.0 0.056 13.2 0.0 2.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase TSC22 PF01166.13 EDK37784.2 - 2.6 8.0 5.8 0.82 9.6 0.9 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family F-box-like PF12937.2 EDK37786.2 - 0.0017 18.0 0.3 0.0074 15.9 0.2 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK37786.2 - 0.012 15.2 0.4 0.012 15.2 0.3 2.7 3 1 1 4 4 4 0 F-box domain GATA PF00320.22 EDK37787.2 - 5.1e-17 60.9 3.9 1e-16 59.9 2.7 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 EDK37787.2 - 1.4e-11 43.7 3.4 2.6e-11 42.9 2.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Rdx PF10262.4 EDK37788.1 - 7.1e-25 86.8 0.1 9.2e-25 86.4 0.0 1.2 1 0 0 1 1 1 1 Rdx family Thioredoxin_2 PF13098.1 EDK37790.2 - 0.036 14.2 0.0 0.072 13.2 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin PF00085.15 EDK37790.2 - 0.072 12.7 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Evr1_Alr PF04777.8 EDK37791.2 - 2.6e-31 107.3 1.2 3.2e-31 107.0 0.9 1.1 1 0 0 1 1 1 1 Erv1 / Alr family HD_3 PF13023.1 EDK37792.1 - 4.5e-37 127.3 0.1 5.6e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 EDK37792.1 - 9.2e-08 32.1 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 HD domain DUF1025 PF06262.6 EDK37792.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Possibl zinc metallo-peptidase Ribosomal_L18e PF00828.14 EDK37793.1 - 3.2e-29 101.8 0.0 3.6e-29 101.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Sugar_tr PF00083.19 EDK37794.2 - 9.8e-53 179.3 10.4 1.5e-52 178.7 7.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37794.2 - 7.3e-11 41.3 36.3 1.4e-08 33.8 13.7 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily COX7C PF02935.11 EDK37794.2 - 8 6.3 8.0 30 4.4 0.2 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc Sugar_tr PF00083.19 EDK37795.2 - 4.4e-34 117.8 9.3 5.6e-34 117.4 6.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK37795.2 - 2e-18 66.2 7.8 2.2e-18 66.1 5.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF791 PF05631.9 EDK37795.2 - 2e-06 26.7 2.5 3e-06 26.1 1.7 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF791) MFS_2 PF13347.1 EDK37795.2 - 2e-05 23.1 0.6 2.8e-05 22.7 0.4 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.8 EDK37795.2 - 0.00045 18.5 2.1 0.00057 18.2 1.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1228 PF06779.9 EDK37795.2 - 0.0083 16.1 1.9 0.069 13.1 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1228) Nuc_H_symport PF03825.11 EDK37795.2 - 0.026 13.3 0.1 0.035 12.8 0.1 1.3 1 1 0 1 1 1 0 Nucleoside H+ symporter Lig_chan PF00060.21 EDK37795.2 - 0.041 13.5 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Ligand-gated ion channel Zn_clus PF00172.13 EDK37796.2 - 9.4e-07 28.6 11.1 1.9e-06 27.6 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 EDK37796.2 - 7.9e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold tRNA_bind PF01588.15 EDK37797.2 - 7.5e-27 93.0 0.1 1.6e-26 91.9 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 EDK37797.2 - 2e-05 24.9 0.0 2e-05 24.9 0.0 2.3 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 EDK37797.2 - 0.0017 18.2 0.1 0.0043 16.9 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain OmpH PF03938.9 EDK37797.2 - 0.0023 17.8 10.3 0.0023 17.8 7.1 2.0 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) NOPS PF08075.6 EDK37797.2 - 0.0078 16.5 0.9 0.022 15.1 0.6 1.8 1 0 0 1 1 1 1 NOPS (NUC059) domain GST_C PF00043.20 EDK37797.2 - 0.031 14.2 0.0 0.031 14.2 0.0 2.5 2 1 0 2 2 1 0 Glutathione S-transferase, C-terminal domain Ycf1 PF05758.7 EDK37797.2 - 0.098 10.3 4.6 0.099 10.3 3.2 1.1 1 0 0 1 1 1 0 Ycf1 DUF1510 PF07423.6 EDK37797.2 - 0.1 11.9 14.3 0.18 11.1 9.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DDHD PF02862.12 EDK37797.2 - 0.25 11.1 2.7 0.37 10.5 1.9 1.4 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.8 EDK37797.2 - 0.26 9.7 8.0 0.39 9.1 5.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.3 EDK37797.2 - 0.37 9.4 17.5 0.54 8.9 12.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Lipoprotein_X PF03305.8 EDK37797.2 - 0.72 9.1 11.7 6.9 5.9 7.9 2.1 2 0 0 2 2 2 0 Mycoplasma MG185/MG260 protein CDC45 PF02724.9 EDK37797.2 - 1.2 7.1 9.5 1.6 6.6 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.11 EDK37797.2 - 1.2 8.0 7.0 1.9 7.4 4.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MCPVI PF02993.9 EDK37797.2 - 2.1 8.4 6.8 3.7 7.6 4.7 1.3 1 0 0 1 1 1 0 Minor capsid protein VI SR-25 PF10500.4 EDK37797.2 - 2.3 7.6 22.8 1.2 8.5 13.9 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Rtf2 PF04641.7 EDK37797.2 - 5 6.2 21.1 8.8 5.4 14.7 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Vfa1 PF08432.5 EDK37797.2 - 8.9 6.2 22.9 3.8 7.4 13.7 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 eRF1_1 PF03463.10 EDK37798.2 - 8.2e-33 112.7 0.5 1.6e-32 111.8 0.3 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 EDK37798.2 - 2.8e-26 92.4 0.1 4.4e-26 91.7 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EDK37798.2 - 4.3e-19 68.8 0.0 1.9e-18 66.7 0.0 2.1 2 0 0 2 2 2 1 eRF1 domain 3 Hce2 PF14856.1 EDK37799.1 - 0.079 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Pathogen effector; putative necrosis-inducing factor Tim17 PF02466.14 EDK37799.1 - 0.4 10.7 8.3 6.7 6.7 5.8 2.3 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.4 EDK37799.1 - 0.67 10.1 9.9 3.7 7.7 1.8 3.2 2 1 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide AAA_23 PF13476.1 EDK37800.2 - 1.1e-16 61.7 20.0 1.1e-16 61.7 13.9 5.6 2 2 3 5 5 1 1 AAA domain SMC_N PF02463.14 EDK37800.2 - 5.5e-15 55.1 38.9 6.9e-14 51.5 27.0 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK37800.2 - 2e-06 27.2 0.0 3.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 EDK37800.2 - 0.00015 21.8 9.8 0.0006 19.8 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA PF00004.24 EDK37800.2 - 0.00073 19.7 5.3 0.001 19.2 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 EDK37800.2 - 0.0062 15.7 0.1 0.02 14.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_33 PF13671.1 EDK37800.2 - 0.027 14.3 0.0 0.027 14.3 0.0 4.0 4 2 0 4 4 3 0 AAA domain AAA_13 PF13166.1 EDK37800.2 - 0.036 12.5 0.1 0.0094 14.4 20.7 5.1 2 2 1 5 5 5 0 AAA domain RNA_helicase PF00910.17 EDK37800.2 - 0.07 13.3 1.1 0.24 11.5 0.1 2.6 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.1 EDK37800.2 - 0.28 11.1 0.1 0.28 11.1 0.1 3.7 4 1 0 4 4 4 0 AAA ATPase domain BLOC1_2 PF10046.4 EDK37800.2 - 5.1 7.3 63.3 1.4 9.1 2.2 8.0 4 2 3 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.4 EDK37800.2 - 7.2 6.4 96.3 0.077 12.8 2.2 6.6 3 2 3 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 EDK37800.2 - 8.5 6.1 90.6 0.19 11.4 15.5 6.4 3 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein tRNA-synt_1c PF00749.16 EDK37801.2 - 2.1e-99 332.1 0.0 2.7e-99 331.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Vps55 PF04133.9 EDK37803.2 - 1.8e-44 150.3 2.4 2.1e-44 150.0 1.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 YwiC PF14256.1 EDK37803.2 - 0.13 12.3 0.2 0.13 12.3 0.1 1.7 2 0 0 2 2 2 0 YwiC-like protein DUF4018 PF13210.1 EDK37803.2 - 0.31 10.4 9.4 0.22 10.8 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4018) MerC PF03203.9 EDK37803.2 - 0.5 10.7 4.0 1.3 9.3 0.1 2.1 2 0 0 2 2 2 0 MerC mercury resistance protein HlyIII PF03006.15 EDK37803.2 - 5.5 6.3 8.4 29 3.9 5.8 1.8 1 1 0 1 1 1 0 Haemolysin-III related SNARE PF05739.14 EDK37804.2 - 2.9e-10 39.6 2.6 2.9e-10 39.6 1.8 2.0 2 0 0 2 2 2 1 SNARE domain YjcZ PF13990.1 EDK37804.2 - 0.028 13.5 1.0 0.038 13.1 0.1 1.6 2 0 0 2 2 2 0 YjcZ-like protein Lipase_GDSL_2 PF13472.1 EDK37804.2 - 0.086 12.9 0.2 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Fib_alpha PF08702.5 EDK37804.2 - 3.6 7.6 5.9 4.4 7.4 0.7 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Lysine_decarbox PF03641.9 EDK37805.1 - 3.3e-43 146.6 0.0 4.4e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase Pro_CA PF00484.14 EDK37806.2 - 2.5e-39 134.7 0.0 3.4e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase SNF2_N PF00176.18 EDK37807.2 - 1.2e-70 237.7 0.6 3.4e-70 236.2 0.4 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK37807.2 - 2.8e-18 65.5 0.0 7.4e-18 64.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK37807.2 - 3.2e-07 29.9 0.0 7.4e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK37807.2 - 3.7e-07 30.1 0.0 3.4e-05 23.7 0.0 3.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Glyco_hydro_15 PF00723.16 EDK37808.2 - 3e-50 171.1 0.0 3.6e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF608 PF04685.8 EDK37808.2 - 0.0027 16.4 0.0 0.0075 15.0 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF608 MMgT PF10270.4 EDK37809.2 - 2.6e-28 98.5 0.2 2.9e-28 98.3 0.1 1.0 1 0 0 1 1 1 1 Membrane magnesium transporter FA_hydroxylase PF04116.8 EDK37810.2 - 7.4e-15 55.3 23.6 7.4e-15 55.3 16.4 2.4 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily VirB3 PF05101.8 EDK37810.2 - 0.0038 17.1 0.2 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Type IV secretory pathway, VirB3-like protein MFS_1 PF07690.11 EDK37811.2 - 3.5e-41 141.0 34.1 6.4e-41 140.2 22.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short_C2 PF13561.1 EDK37812.1 - 2.8e-26 92.7 0.1 3.4e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK37812.1 - 9.8e-21 74.3 0.1 1.2e-20 74.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK37812.1 - 1.3e-06 28.2 0.1 1.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK37812.1 - 0.031 13.7 0.2 0.075 12.4 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EDK37812.1 - 0.1 11.4 0.1 0.48 9.2 0.0 2.0 2 1 0 2 2 2 0 RmlD substrate binding domain Peptidase_M3 PF01432.15 EDK37813.2 - 5.8e-102 342.0 0.1 7e-102 341.8 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 EDK37813.2 - 0.014 14.7 0.2 0.022 14.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Peptidase_M3 PF01432.15 EDK37814.2 - 1e-30 107.2 3.7 1e-30 107.2 2.6 1.4 2 0 0 2 2 2 1 Peptidase family M3 Gtr1_RagA PF04670.7 EDK37815.2 - 4.5e-70 235.3 0.1 5.7e-70 235.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EDK37815.2 - 0.00053 19.2 0.0 0.0016 17.7 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.1 EDK37815.2 - 0.072 12.9 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 EDK37815.2 - 0.1 11.8 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF815 PF05673.8 EDK37815.2 - 0.11 11.3 0.0 0.25 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) tRNA-synt_2 PF00152.15 EDK37816.2 - 3.4e-81 272.6 0.4 4.1e-81 272.3 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK37816.2 - 6.5e-05 22.7 0.1 0.00015 21.5 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TYW3 PF02676.9 EDK37817.2 - 5.8e-72 241.1 0.0 7.5e-72 240.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 GRIP PF01465.15 EDK37818.2 - 7.8e-18 63.7 0.2 2.9e-17 61.9 0.1 2.1 1 0 0 1 1 1 1 GRIP domain Reo_sigmaC PF04582.7 EDK37818.2 - 3.5e-05 23.1 74.5 0.0054 15.9 7.6 7.3 2 1 6 8 8 8 6 Reovirus sigma C capsid protein ATG16 PF08614.6 EDK37818.2 - 0.0014 18.4 18.2 0.0014 18.4 12.6 8.7 2 1 5 8 8 8 2 Autophagy protein 16 (ATG16) DUF2968 PF11180.3 EDK37818.2 - 0.0018 17.7 10.2 0.0018 17.7 7.1 7.9 3 1 3 8 8 8 1 Protein of unknown function (DUF2968) APG6 PF04111.7 EDK37818.2 - 0.0039 16.2 19.2 0.0039 16.2 13.3 8.5 2 1 7 9 9 9 5 Autophagy protein Apg6 Rootletin PF15035.1 EDK37818.2 - 0.0075 16.2 13.4 0.0075 16.2 9.3 8.0 2 2 5 7 7 7 2 Ciliary rootlet component, centrosome cohesion MscS_porin PF12795.2 EDK37818.2 - 9.6 5.4 130.2 0.01 15.1 8.8 7.1 2 1 4 6 6 6 0 Mechanosensitive ion channel porin domain RasGEF PF00617.14 EDK37819.2 - 1.7e-61 207.2 1.3 1.7e-61 207.2 0.9 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 EDK37819.2 - 1e-20 73.7 1.7 3.4e-20 72.0 0.3 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.23 EDK37819.2 - 6e-15 54.3 0.0 1.7e-14 52.9 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK37819.2 - 2e-10 40.0 0.1 4.1e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK37819.2 - 5.3e-06 25.8 0.0 1.2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Vps26 PF03643.10 EDK37820.2 - 3.7e-114 380.1 0.3 4.2e-114 379.9 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 EDK37820.2 - 1.4e-06 28.2 0.6 0.042 13.6 0.1 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Mito_carr PF00153.22 EDK37821.2 - 3.3e-13 49.1 2.0 5.4e-08 32.4 0.2 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein BacA PF02673.13 EDK37821.2 - 0.007 15.5 0.2 0.15 11.2 0.0 2.2 2 0 0 2 2 2 1 Bacitracin resistance protein BacA OMPdecase PF00215.19 EDK37822.2 - 1.2e-76 257.1 0.0 1.4e-76 256.8 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Sec7 PF01369.15 EDK37823.2 - 1.5e-61 207.3 0.2 4.1e-61 205.9 0.1 1.7 1 0 0 1 1 1 1 Sec7 domain SQS_PSY PF00494.14 EDK37824.1 - 1.4e-23 83.6 0.0 2e-23 83.0 0.0 1.3 1 1 0 1 1 1 1 Squalene/phytoene synthase DUF1706 PF08020.6 EDK37824.1 - 0.062 12.7 0.1 0.2 11.1 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1706) Pro_isomerase PF00160.16 EDK37825.2 - 3.1e-25 89.2 0.5 6e-25 88.2 0.4 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 EDK37825.2 - 1e-11 44.2 4.6 1.1e-05 24.9 0.4 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EDK37825.2 - 3.2e-10 39.1 1.6 6.4e-06 25.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK37825.2 - 1.5e-06 27.5 3.4 8.4e-06 25.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK37825.2 - 8.8e-06 25.5 0.5 0.00035 20.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK37825.2 - 4.4e-05 22.9 1.0 0.0015 18.1 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK37825.2 - 9.9e-05 22.9 0.8 0.00045 20.8 0.1 2.3 3 0 0 3 3 2 1 Tetratricopeptide repeat DUF4398 PF14346.1 EDK37825.2 - 0.024 14.6 4.3 0.05 13.6 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) Apc3 PF12895.2 EDK37825.2 - 0.024 14.7 4.4 0.055 13.6 0.7 2.3 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ApoA-II PF04711.8 EDK37825.2 - 0.024 14.5 1.6 0.032 14.1 0.0 2.0 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) TPR_14 PF13428.1 EDK37825.2 - 0.046 14.3 0.1 0.21 12.3 0.0 2.1 3 0 0 3 3 1 0 Tetratricopeptide repeat TPR_19 PF14559.1 EDK37825.2 - 0.047 14.0 0.4 0.15 12.3 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 EDK37825.2 - 0.11 12.3 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_2 PF13639.1 EDK37826.2 - 4.1e-12 45.7 6.2 3.1e-11 42.9 0.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 EDK37826.2 - 5.5e-09 36.0 1.4 1.3e-07 31.6 0.1 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EDK37826.2 - 3.2e-07 30.2 3.6 2.4e-06 27.4 0.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK37826.2 - 6.3e-07 28.9 4.8 5.1e-06 26.0 0.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK37826.2 - 8.5e-07 28.5 2.0 5.2e-06 26.0 0.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK37826.2 - 3.6e-05 23.4 5.9 0.00011 21.8 0.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 EDK37826.2 - 8.7e-05 22.1 4.8 0.00011 21.8 0.1 3.2 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK37826.2 - 0.00016 21.4 1.0 0.00016 21.4 0.7 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 EDK37826.2 - 0.00062 19.5 0.4 0.0024 17.6 0.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 EDK37826.2 - 0.0052 16.3 0.5 0.014 14.8 0.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 U-box PF04564.10 EDK37826.2 - 0.012 15.5 0.0 0.037 13.9 0.0 1.8 1 0 0 1 1 1 0 U-box domain FANCL_C PF11793.3 EDK37826.2 - 0.06 13.3 5.3 0.1 12.5 0.8 2.9 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.1 EDK37826.2 - 0.075 12.6 3.5 0.075 12.6 0.3 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 EDK37826.2 - 6.1 6.9 7.5 0.81 9.7 0.9 2.2 2 0 0 2 2 2 0 RING-variant domain Asp PF00026.18 EDK37827.2 - 1.6e-60 205.0 10.4 2.9e-60 204.1 7.2 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 EDK37827.2 - 4e-07 30.4 0.3 0.67 10.4 0.0 3.6 3 0 0 3 3 3 3 Aspartyl protease TAXi_N PF14543.1 EDK37827.2 - 1.4e-06 28.3 0.0 6.4e-05 22.9 0.0 3.4 2 2 1 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EDK37827.2 - 2.3e-05 23.9 0.0 0.00098 18.6 0.0 2.9 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal RVP PF00077.15 EDK37827.2 - 0.016 15.1 0.0 2.4 8.1 0.0 3.2 3 0 0 3 3 3 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 EDK37827.2 - 0.073 12.9 0.1 5.9 6.7 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Formyl_trans_C PF02911.13 EDK37828.2 - 0.13 12.3 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Formyl transferase, C-terminal domain Zn_clus PF00172.13 EDK37829.2 - 5.2e-05 23.0 9.9 9.6e-05 22.2 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Complex1_30kDa PF00329.14 EDK37830.1 - 1.4e-35 121.6 0.1 2.3e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit End3 PF12761.2 EDK37831.2 - 9.3e-69 230.9 7.7 1.4e-68 230.4 5.3 1.3 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.2 EDK37831.2 - 3.9e-56 187.1 0.1 2.8e-54 181.2 0.1 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 EDK37831.2 - 4.8e-05 22.3 1.2 0.00013 21.0 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 EDK37831.2 - 0.0021 18.1 0.0 0.018 15.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair TBPIP PF07106.8 EDK37831.2 - 0.0057 16.2 4.0 0.0057 16.2 2.7 2.6 2 1 1 3 3 3 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) EF-hand_8 PF13833.1 EDK37831.2 - 0.0091 15.5 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Fib_alpha PF08702.5 EDK37831.2 - 0.19 11.8 7.0 0.34 11.0 4.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Med9 PF07544.8 EDK37831.2 - 1.2 8.9 6.0 0.51 10.1 1.0 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 EDK37831.2 - 2.4 7.7 7.8 4 6.9 5.4 1.4 1 0 0 1 1 1 0 IncA protein FlxA PF14282.1 EDK37831.2 - 3.1 7.7 8.8 7.8 6.4 6.1 1.7 1 0 0 1 1 1 0 FlxA-like protein Ribosomal_S13 PF00416.17 EDK37832.2 - 9e-16 58.2 0.1 1.1e-15 57.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 EOS1 PF12326.3 EDK37833.2 - 2.2e-57 192.8 11.1 4e-57 192.0 7.7 1.4 1 0 0 1 1 1 1 N-glycosylation protein Myb_DNA-bind_3 PF12776.2 EDK37835.1 - 0.0021 18.6 0.7 0.0035 17.9 0.5 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Vac14_Fig4_bd PF11916.3 EDK37836.2 - 3.2e-69 231.7 10.6 3.2e-69 231.7 7.3 1.8 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 EDK37836.2 - 7.5e-36 122.4 1.9 2.4e-35 120.8 0.3 2.7 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.1 EDK37836.2 - 1.8e-06 28.1 0.0 0.0013 19.0 0.0 4.4 5 1 0 5 5 5 1 HEAT repeats HEAT PF02985.17 EDK37836.2 - 1.6e-05 24.5 2.0 0.01 15.8 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 EDK37836.2 - 0.00047 20.5 0.0 0.14 12.6 0.0 3.9 3 0 0 3 3 3 1 HEAT-like repeat DUF3385 PF11865.3 EDK37836.2 - 0.086 12.7 6.8 3.8 7.4 0.0 4.8 5 1 0 5 5 5 0 Domain of unknown function (DUF3385) DnaJ PF00226.26 EDK37837.2 - 3.2e-23 81.2 3.0 5.2e-23 80.5 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EDK37837.2 - 6.2e-11 42.1 17.2 1e-10 41.4 12.0 1.3 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 EDK37837.2 - 6.7e-10 38.7 3.1 0.00012 21.9 0.2 4.3 4 1 0 4 4 4 2 DnaJ C terminal domain zf-C2H2_2 PF12756.2 EDK37838.2 - 1.3e-30 105.4 11.0 7.1e-29 99.8 0.7 3.6 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 EDK37838.2 - 0.0075 16.3 0.4 0.0075 16.3 0.3 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.7 EDK37838.2 - 0.031 14.0 9.2 0.77 9.5 0.7 2.9 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.21 EDK37838.2 - 0.13 12.6 0.5 0.13 12.6 0.3 3.6 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK37838.2 - 0.55 10.6 7.3 6.9 7.2 0.0 3.4 3 1 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.7 EDK37838.2 - 3.2 7.9 7.6 5.7 7.1 0.6 3.2 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF663 PF04950.7 EDK37839.2 - 3.4e-92 308.5 0.6 1.9e-91 306.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 EDK37839.2 - 3.7e-22 77.6 0.0 1.8e-21 75.4 0.0 2.3 2 0 0 2 2 2 1 AARP2CN (NUC121) domain Ribosomal_S14 PF00253.16 EDK37840.1 - 1.4e-18 65.9 4.6 1.5e-18 65.8 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Prim_Zn_Ribbon PF08273.7 EDK37840.1 - 0.066 13.2 1.7 2.8 8.0 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF2296 PF10058.4 EDK37840.1 - 0.23 11.2 2.3 2.3 8.0 0.0 2.1 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Arm PF00514.18 EDK37841.2 - 0.025 14.4 2.0 0.56 10.1 0.0 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EDK37841.2 - 0.099 12.9 0.5 0.49 10.7 0.1 2.4 3 0 0 3 3 3 0 HEAT repeats Pyridox_oxidase PF01243.15 EDK37842.1 - 0.18 11.8 0.2 0.18 11.8 0.1 2.0 2 1 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Flocculin_t3 PF13928.1 EDK37843.2 - 0.012 15.7 31.3 0.051 13.7 11.7 2.4 1 1 1 2 2 2 0 Flocculin type 3 repeat DUF605 PF04652.11 EDK37844.1 - 9.4 5.5 8.5 12 5.1 5.9 1.1 1 0 0 1 1 1 0 Vta1 like Peptidase_S64 PF08192.6 EDK37845.2 - 2.8e-241 802.6 2.9 3.4e-241 802.4 2.0 1.0 1 0 0 1 1 1 1 Peptidase family S64 6PF2K PF01591.13 EDK37846.2 - 4.6e-86 287.4 0.5 7.4e-86 286.8 0.4 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 EDK37846.2 - 9.4e-33 113.5 0.1 1.5e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 EDK37846.2 - 4e-07 30.0 0.0 7.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EDK37846.2 - 0.0019 17.4 0.0 0.0033 16.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 EDK37846.2 - 0.0074 17.0 0.1 0.065 14.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain UQ_con PF00179.21 EDK37847.1 - 3.5e-45 152.8 0.1 4e-45 152.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK37847.1 - 0.00083 19.1 0.0 0.0013 18.4 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EDK37847.1 - 0.021 14.7 2.2 0.035 13.9 1.5 1.8 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 EDK37847.1 - 0.026 14.2 0.8 0.072 12.7 0.6 1.7 1 1 0 1 1 1 0 UEV domain Pex19 PF04614.7 EDK37848.2 - 2.6e-78 263.0 13.8 5.4e-78 262.0 9.6 1.6 1 1 0 1 1 1 1 Pex19 protein family TBCA PF02970.11 EDK37848.2 - 0.019 15.0 4.0 0.019 15.0 2.8 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF445 PF04286.7 EDK37848.2 - 0.036 13.5 4.1 0.23 10.9 2.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF445) DUF2624 PF11116.3 EDK37848.2 - 0.045 14.2 1.2 1.9 9.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) AAA_31 PF13614.1 EDK37848.2 - 0.67 9.8 3.6 1.4 8.8 0.3 2.3 1 1 2 3 3 3 0 AAA domain ISG65-75 PF11727.3 EDK37848.2 - 5.4 5.9 6.9 1.4 7.8 1.6 2.0 2 0 0 2 2 2 0 Invariant surface glycoprotein Fib_alpha PF08702.5 EDK37848.2 - 7 6.7 9.9 5.5 7.1 0.4 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Lipoprotein_7 PF01540.11 EDK37848.2 - 8.2 5.3 12.6 0.63 9.0 4.0 2.4 3 0 0 3 3 3 0 Adhesin lipoprotein AAA PF00004.24 EDK37849.2 - 2.2e-91 302.9 0.0 1.3e-44 151.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK37849.2 - 1.7e-12 47.7 0.1 3.2e-06 27.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.7 EDK37849.2 - 1e-11 44.3 0.0 1.5e-05 24.2 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 EDK37849.2 - 1.1e-10 41.4 0.1 0.00083 19.1 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EDK37849.2 - 1.8e-10 41.0 0.4 0.00016 21.7 0.0 4.4 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 EDK37849.2 - 2.1e-09 37.3 0.0 6.7e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 EDK37849.2 - 1.8e-08 34.4 0.0 0.0029 17.5 0.0 3.0 2 2 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 EDK37849.2 - 5.3e-07 29.5 0.0 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 EDK37849.2 - 6.6e-07 28.3 0.0 0.014 14.1 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus AAA_17 PF13207.1 EDK37849.2 - 1.9e-06 28.7 0.0 0.048 14.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EDK37849.2 - 5.3e-06 26.5 0.0 0.074 13.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 EDK37849.2 - 7.2e-06 25.6 2.0 0.0015 18.2 0.0 3.0 3 0 0 3 3 2 1 Part of AAA domain Rad17 PF03215.10 EDK37849.2 - 2.9e-05 22.9 0.1 0.072 11.7 0.1 3.8 3 1 1 4 4 4 1 Rad17 cell cycle checkpoint protein NACHT PF05729.7 EDK37849.2 - 3.2e-05 23.6 0.0 0.0042 16.7 0.0 3.4 4 0 0 4 4 4 1 NACHT domain AAA_28 PF13521.1 EDK37849.2 - 3.5e-05 23.8 0.0 0.055 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 EDK37849.2 - 3.6e-05 23.0 0.1 0.12 11.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 EDK37849.2 - 4.2e-05 23.0 4.0 0.64 9.3 0.0 4.1 2 2 1 3 3 3 1 AAA domain Zeta_toxin PF06414.7 EDK37849.2 - 6.1e-05 22.2 0.0 0.064 12.3 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_3 PF07726.6 EDK37849.2 - 7.7e-05 22.3 0.0 0.34 10.5 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 EDK37849.2 - 0.00022 21.2 0.0 0.11 12.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain Bac_DnaA PF00308.13 EDK37849.2 - 0.00039 20.1 0.0 0.026 14.1 0.0 2.9 2 2 0 2 2 2 1 Bacterial dnaA protein Arch_ATPase PF01637.13 EDK37849.2 - 0.00053 19.7 0.0 0.48 10.0 0.0 3.2 2 2 0 2 2 2 1 Archaeal ATPase IstB_IS21 PF01695.12 EDK37849.2 - 0.001 18.5 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein DUF815 PF05673.8 EDK37849.2 - 0.0016 17.4 0.0 0.17 10.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_11 PF13086.1 EDK37849.2 - 0.0038 16.8 0.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 EDK37849.2 - 0.0041 16.7 0.7 0.16 11.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.22 EDK37849.2 - 0.0043 17.3 0.0 0.34 11.2 0.0 2.9 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.1 EDK37849.2 - 0.0046 17.2 0.0 0.17 12.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 EDK37849.2 - 0.0056 16.2 0.0 0.1 12.0 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 EDK37849.2 - 0.006 16.3 0.1 0.33 10.6 0.0 3.5 3 2 2 5 5 4 1 NTPase AAA_24 PF13479.1 EDK37849.2 - 0.008 15.7 0.1 1.8 8.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 EDK37849.2 - 0.012 14.7 0.1 3.6 6.6 0.0 3.1 3 0 0 3 3 3 0 KaiC UPF0079 PF02367.12 EDK37849.2 - 0.013 15.1 0.1 0.24 11.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activat PF00158.21 EDK37849.2 - 0.017 14.5 0.0 8.1 5.8 0.0 3.7 3 1 0 3 3 3 0 Sigma-54 interaction domain ATP-synt_ab PF00006.20 EDK37849.2 - 0.031 13.7 0.0 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AFG1_ATPase PF03969.11 EDK37849.2 - 0.041 12.6 0.2 0.21 10.3 0.0 2.0 2 1 0 2 2 2 0 AFG1-like ATPase DSHCT PF08148.7 EDK37851.2 - 1.2e-61 207.1 0.1 2.9e-61 205.8 0.1 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EDK37851.2 - 1e-22 80.4 0.0 2.6e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.1 EDK37851.2 - 4.4e-06 26.0 7.1 1.1e-05 24.7 3.0 2.8 2 1 0 2 2 2 1 rRNA-processing arch domain Helicase_C PF00271.26 EDK37851.2 - 3e-05 23.8 0.0 7.8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK37851.2 - 0.0062 16.3 0.1 0.022 14.5 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PP2C PF00481.16 EDK37852.2 - 4.7e-43 147.4 0.0 7.5e-43 146.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 EDK37852.2 - 0.026 13.9 0.0 0.055 12.8 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C SpoIIE PF07228.7 EDK37852.2 - 0.18 11.5 0.0 2 8.0 0.0 2.4 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Ribosomal_S10 PF00338.17 EDK37853.1 - 3.4e-28 97.3 1.3 4.5e-28 96.9 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ActA PF05058.7 EDK37853.1 - 0.022 12.7 0.2 0.025 12.5 0.1 1.1 1 0 0 1 1 1 0 ActA Protein MRP-L28 PF09812.4 EDK37853.1 - 0.053 13.3 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Tnp_P_element PF12017.3 EDK37853.1 - 0.075 12.2 0.1 0.077 12.2 0.0 1.1 1 0 0 1 1 1 0 Transposase protein ATP-synt_10 PF05176.9 EDK37854.2 - 1.5e-89 299.6 0.1 1.8e-89 299.3 0.1 1.0 1 0 0 1 1 1 1 ATP10 protein DCP2 PF05026.8 EDK37855.2 - 3.9e-33 113.2 0.0 7.1e-33 112.3 0.0 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 EDK37855.2 - 2.1e-12 46.8 0.0 4.8e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain SUZ PF12752.2 EDK37855.2 - 0.8 10.2 10.3 3.6 8.1 0.2 4.2 4 1 0 4 4 4 0 SUZ domain LRR_6 PF13516.1 EDK37856.2 - 0.086 12.9 0.8 3.5 7.9 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich repeat RIO1 PF01163.17 EDK37857.2 - 5.5e-41 139.9 1.1 2.3e-40 137.9 0.7 2.0 1 1 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 EDK37857.2 - 6.8e-34 115.7 0.2 7.9e-33 112.3 0.0 2.6 3 0 0 3 3 3 1 Rio2, N-terminal APH PF01636.18 EDK37857.2 - 6.1e-08 32.6 0.0 0.00016 21.4 0.0 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 EDK37857.2 - 0.00023 20.2 0.0 0.0039 16.2 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EDK37857.2 - 0.0032 16.6 0.1 0.0048 16.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain HSP70 PF00012.15 EDK37858.1 - 1.5e-236 786.0 10.8 1.8e-236 785.7 7.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EDK37858.1 - 2.9e-17 62.2 1.4 5.7e-16 58.0 0.5 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EDK37858.1 - 0.0017 18.0 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain ATP-synt_DE PF00401.15 EDK37858.1 - 8.5 6.3 13.5 0.079 12.8 2.6 2.7 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Y_phosphatase PF00102.22 EDK37859.2 - 1.8e-56 191.1 0.5 2.7e-56 190.5 0.4 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EDK37859.2 - 0.0042 17.1 0.0 0.0086 16.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.15 EDK37859.2 - 0.12 11.9 0.3 0.23 11.0 0.2 1.6 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain NMT1 PF09084.6 EDK37860.2 - 1.2e-16 61.0 0.0 3.1e-16 59.6 0.0 1.6 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 EDK37860.2 - 5.7e-05 22.6 0.0 8.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.15 EDK37860.2 - 7.3e-05 22.1 0.0 0.00015 21.1 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.15 EDK37860.2 - 0.022 13.8 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 LysR substrate binding domain VitK2_biosynth PF02621.9 EDK37860.2 - 0.1 11.8 0.0 0.34 10.0 0.0 1.8 2 0 0 2 2 2 0 Menaquinone biosynthesis Ras PF00071.17 EDK37861.2 - 3.6e-59 198.7 0.0 4.1e-59 198.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK37861.2 - 2.4e-19 69.9 0.0 3.6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK37861.2 - 7.4e-14 51.3 0.0 8.8e-14 51.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK37861.2 - 2.7e-08 33.2 0.0 3.4e-08 32.9 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EDK37861.2 - 1.9e-05 24.2 0.0 5.3e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK37861.2 - 3.1e-05 23.8 0.0 4.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EDK37861.2 - 0.0028 17.6 0.0 0.004 17.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EDK37861.2 - 0.021 14.0 0.1 0.098 11.8 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 EDK37861.2 - 0.088 12.9 0.0 0.28 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain N2227 PF07942.7 EDK37862.2 - 1.3e-87 293.2 0.0 1.7e-87 292.8 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 EDK37862.2 - 5.2e-05 23.0 0.0 0.00021 21.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK37862.2 - 0.034 14.6 0.0 0.57 10.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 EDK37862.2 - 0.13 12.8 0.0 1.7 9.2 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 EDK37862.2 - 0.13 11.8 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Zn_clus PF00172.13 EDK37863.2 - 2.6e-07 30.4 8.0 4.4e-07 29.6 5.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 EDK37865.2 - 2.3e-07 30.6 8.0 4.5e-07 29.6 5.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MutL_C PF08676.6 EDK37866.2 - 5.7e-23 81.1 0.0 1e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 EDK37866.2 - 4.3e-20 71.3 1.2 1.2e-19 69.9 0.1 2.3 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.21 EDK37866.2 - 4e-11 42.6 0.1 9.9e-11 41.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EDK37866.2 - 6.8e-11 41.9 0.1 6.8e-11 41.9 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HORMA PF02301.13 EDK37867.2 - 6.5e-27 94.3 1.0 7.4e-27 94.1 0.7 1.0 1 0 0 1 1 1 1 HORMA domain Mito_carr PF00153.22 EDK37868.2 - 2.7e-64 212.8 0.1 7.9e-21 73.5 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 EDK37868.2 - 3.4e-22 78.3 14.0 6e-11 42.3 2.5 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 EDK37868.2 - 2.1e-20 70.3 14.6 0.00014 20.9 0.4 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 EDK37868.2 - 1.5e-18 66.1 7.6 1.7e-07 30.7 0.1 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 EDK37868.2 - 4.1e-18 63.5 18.6 0.00024 20.7 0.2 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 EDK37868.2 - 4.1e-11 41.6 9.6 0.0012 18.1 0.1 4.6 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 EDK37868.2 - 0.00014 21.8 2.5 0.3 11.1 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.7 EDK37868.2 - 0.0094 16.2 2.4 0.31 11.2 0.1 3.1 1 1 2 3 3 3 1 p25-alpha TAFH PF07531.9 EDK37868.2 - 0.15 11.7 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 NHR1 homology to TAF EF-hand_10 PF14788.1 EDK37868.2 - 2.1 8.1 5.4 1.1 9.0 0.2 3.0 3 1 1 4 4 4 0 EF hand Cpn60_TCP1 PF00118.19 EDK37869.2 - 6.2e-134 447.2 13.9 7.3e-134 447.0 9.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ldl_recept_b PF00058.12 EDK37869.2 - 0.097 13.0 0.0 0.54 10.6 0.0 2.3 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B AMPKBI PF04739.10 EDK37872.1 - 1.3e-33 114.8 0.9 1.3e-33 114.8 0.6 1.8 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain STE2 PF02116.10 EDK37873.2 - 1.2e-89 300.1 25.7 1.4e-89 299.9 17.8 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR ICE2 PF08426.5 EDK37874.2 - 8.3e-169 561.5 27.0 1e-168 561.2 18.7 1.1 1 0 0 1 1 1 1 ICE2 DUF1253 PF06862.7 EDK37875.2 - 1.6e-166 554.1 7.6 2.2e-166 553.6 5.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DEAD PF00270.24 EDK37875.2 - 0.064 12.7 0.5 0.69 9.3 0.2 2.4 2 1 0 2 2 2 0 DEAD/DEAH box helicase Ribosomal_L35p PF01632.14 EDK37875.2 - 0.1 12.5 1.9 0.32 10.9 1.3 1.8 1 0 0 1 1 1 0 Ribosomal protein L35 Y_phosphatase2 PF03162.8 EDK37876.2 - 7.5e-58 194.5 0.0 1.3e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EDK37876.2 - 1.4e-07 31.9 0.0 6.5e-07 29.7 0.0 2.1 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 EDK37876.2 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.15 EDK37876.2 - 0.0033 17.0 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF2416 PF10315.4 EDK37877.2 - 4.3e-44 149.1 0.9 4.9e-44 148.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2416) Histone PF00125.19 EDK37878.1 - 1.9e-31 108.0 0.5 3.1e-31 107.3 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EDK37878.1 - 2e-06 27.9 0.0 3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EDK37878.1 - 0.0058 16.6 0.6 0.0087 16.1 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EDK37878.1 - 0.056 13.1 0.1 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Sds3 PF08598.6 EDK37879.2 - 9.9e-18 64.4 1.4 1.4e-17 63.9 1.0 1.2 1 0 0 1 1 1 1 Sds3-like GHMP_kinases_N PF00288.21 EDK37879.2 - 0.046 13.7 1.5 0.14 12.2 1.0 1.8 1 0 0 1 1 1 0 GHMP kinases N terminal domain Acetyltransf_1 PF00583.19 EDK37880.1 - 6.1e-05 22.9 0.1 0.00032 20.6 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EDK37880.1 - 0.008 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EDK37880.1 - 0.059 13.5 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK37880.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PolyA_pol_RNAbd PF12627.2 EDK37880.1 - 0.17 11.4 0.0 0.52 9.9 0.0 1.8 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A zf-H2C2 PF09337.5 EDK37881.2 - 1.6e-21 75.3 3.3 3.1e-21 74.4 2.3 1.5 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_1 PF00583.19 EDK37881.2 - 1.5e-07 31.3 0.0 8.8e-07 28.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 EDK37881.2 - 0.0007 19.5 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK37881.2 - 0.0018 18.4 0.0 0.029 14.4 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EDK37881.2 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Imm47 PF15586.1 EDK37881.2 - 0.15 11.9 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 47 FR47 PF08445.5 EDK37881.2 - 0.15 11.8 0.0 0.74 9.6 0.0 2.0 2 0 0 2 2 2 0 FR47-like protein CPSase_L_D2 PF02786.12 EDK37882.2 - 1.1e-114 380.9 0.9 4.6e-84 280.9 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 EDK37882.2 - 6.4e-46 155.0 0.0 1.5e-45 153.8 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.16 EDK37882.2 - 9.9e-45 151.6 0.0 2.2e-44 150.5 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.23 EDK37882.2 - 2.1e-43 147.9 0.0 5.9e-43 146.5 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_chain PF00289.17 EDK37882.2 - 8e-42 141.8 0.0 1.5e-20 73.3 0.0 3.2 3 0 0 3 3 3 2 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 EDK37882.2 - 3.3e-40 136.6 0.0 6.7e-40 135.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EDK37882.2 - 2.2e-37 128.5 0.4 1.3e-22 80.4 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain OTCace PF00185.19 EDK37882.2 - 1.8e-32 112.3 0.1 4.7e-32 111.0 0.1 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATPgrasp_Ter PF15632.1 EDK37882.2 - 1.8e-22 79.5 0.0 1.4e-11 43.7 0.0 3.5 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 EDK37882.2 - 3.2e-21 75.0 0.0 1.8e-20 72.6 0.0 2.5 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.8 EDK37882.2 - 3e-16 59.4 1.0 2.5e-09 36.7 0.1 2.7 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EDK37882.2 - 2.1e-15 56.4 0.9 6.1e-07 28.9 0.0 2.7 3 0 0 3 3 3 2 ATP-grasp domain ATP-grasp_3 PF02655.9 EDK37882.2 - 5.2e-08 32.9 0.4 0.0041 17.0 0.1 3.3 3 0 0 3 3 3 2 ATP-grasp domain Peptidase_C26 PF07722.8 EDK37882.2 - 6e-07 29.1 0.1 1.8e-05 24.2 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 RimK PF08443.6 EDK37882.2 - 1.9e-05 24.2 0.0 0.00043 19.8 0.0 2.5 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.14 EDK37882.2 - 0.0042 16.6 0.5 2 7.9 0.0 2.8 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MFS_1 PF07690.11 EDK37883.2 - 5.4e-43 147.0 33.1 5.4e-43 147.0 22.9 2.5 3 0 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK37883.2 - 2.1e-08 33.1 7.5 2.1e-08 33.1 5.2 3.3 3 0 0 3 3 3 2 Sugar (and other) transporter TrkH PF02386.11 EDK37884.2 - 2e-137 457.5 20.9 2.3e-136 454.0 7.5 2.1 2 0 0 2 2 2 2 Cation transport protein CDC45 PF02724.9 EDK37884.2 - 1.1 7.1 8.8 2 6.3 6.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Upf2 PF04050.9 EDK37884.2 - 3.7 7.2 11.5 13 5.5 8.0 1.8 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Brix PF04427.13 EDK37885.1 - 4.4e-47 160.2 1.7 6.2e-47 159.7 1.2 1.2 1 0 0 1 1 1 1 Brix domain RICTOR_M PF14666.1 EDK37888.2 - 3.8e-83 277.9 1.7 1.3e-79 266.3 0.2 4.4 4 1 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_N PF14664.1 EDK37888.2 - 3.1e-79 266.2 1.0 3.1e-79 266.2 0.7 1.6 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_V PF14668.1 EDK37888.2 - 3e-14 52.6 1.0 5.8e-13 48.5 0.1 3.4 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.1 EDK37888.2 - 7.5e-12 45.2 0.1 2.5e-10 40.2 0.0 3.2 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF2944 PF11161.3 EDK37888.2 - 0.05 13.2 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) UPF0139 PF03669.8 EDK37888.2 - 0.12 11.8 0.0 4.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) YopR_core PF09025.5 EDK37889.2 - 0.011 15.7 0.9 0.018 15.0 0.6 1.5 1 0 0 1 1 1 0 YopR Core DUF2096 PF09869.4 EDK37889.2 - 0.077 12.8 0.3 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) ASF1_hist_chap PF04729.8 EDK37890.2 - 4.8e-67 224.3 0.1 6.7e-67 223.9 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone CobT PF06213.7 EDK37890.2 - 1.6 7.7 21.7 2 7.5 15.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 EDK37890.2 - 2.2 6.1 23.8 2.4 5.9 16.5 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 EDK37890.2 - 5.6 6.1 15.0 6.4 5.9 10.4 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T RNA_pol_3_Rpc31 PF11705.3 EDK37890.2 - 6.4 6.6 21.7 11 5.8 15.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.9 EDK37890.2 - 8.1 4.3 15.4 9.5 4.1 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 EDK37890.2 - 10 4.4 24.9 11 4.4 17.2 1.1 1 0 0 1 1 1 0 Daxx Family F-protein PF00469.15 EDK37891.2 - 0.044 13.1 4.7 1.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef SelP_N PF04592.9 EDK37891.2 - 0.65 9.3 7.4 1.4 8.2 5.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RRN3 PF05327.6 EDK37891.2 - 6.3 4.7 8.5 11 4.0 5.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Mem_trans PF03547.13 EDK37892.2 - 1.7e-56 191.1 11.9 2.1e-56 190.8 8.3 1.1 1 0 0 1 1 1 1 Membrane transport protein Ras PF00071.17 EDK37893.2 - 9.4e-50 168.1 0.2 1.1e-49 167.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK37893.2 - 2.6e-19 69.8 0.2 3.7e-19 69.3 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 EDK37893.2 - 5.1e-09 35.8 0.1 3.2e-08 33.2 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 EDK37893.2 - 3.6e-07 29.5 0.0 3.9e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EDK37893.2 - 4.1e-06 26.7 0.0 6.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK37893.2 - 0.00017 20.9 0.0 0.0014 17.9 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.5 EDK37893.2 - 0.00019 20.6 0.0 0.0003 20.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 EDK37893.2 - 0.04 13.8 0.0 0.052 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain GDA1_CD39 PF01150.12 EDK37894.2 - 1.2e-78 264.5 0.0 2.3e-78 263.6 0.0 1.3 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Cytochrom_B_N PF00033.14 EDK37894.2 - 0.041 13.2 0.1 0.071 12.4 0.1 1.3 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB CLTH PF10607.4 EDK37895.2 - 4.6e-35 120.4 1.0 1.1e-34 119.2 0.7 1.7 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DUF2431 PF10354.4 EDK37896.2 - 6.2e-58 195.4 1.2 6.7e-58 195.3 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) HTH_Tnp_Mu_1 PF02316.11 EDK37896.2 - 0.0065 16.1 0.5 11 5.6 0.1 3.1 2 1 1 3 3 3 2 Mu DNA-binding domain UCH PF00443.24 EDK37897.2 - 1.1e-47 162.3 0.1 1.7e-47 161.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK37897.2 - 3.5e-11 43.0 0.0 8.5e-11 41.8 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.17 EDK37898.2 - 4e-47 157.7 0.1 1.6e-16 59.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37898.2 - 2e-32 110.9 0.0 4e-12 45.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37898.2 - 9.1e-28 95.8 0.0 6.9e-09 35.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK37898.2 - 0.0093 15.7 0.0 0.57 9.9 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 EDK37898.2 - 0.041 13.8 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF424 PF04242.8 EDK37898.2 - 0.062 13.3 0.2 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF424) ESR1_C PF12743.2 EDK37898.2 - 0.25 10.9 5.5 0.65 9.5 3.8 1.7 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal Met_10 PF02475.11 EDK37899.1 - 1.9e-11 43.9 0.0 4.1e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_26 PF13659.1 EDK37899.1 - 0.0085 16.1 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2 PF00096.21 EDK37900.2 - 2.7e-13 49.3 16.9 2.2e-06 27.6 3.3 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK37900.2 - 6.6e-13 48.2 13.5 8.6e-09 35.2 0.3 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK37900.2 - 5.2e-11 42.0 14.7 0.002 18.3 2.4 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK37900.2 - 7.7e-08 32.2 5.6 0.00092 19.2 0.5 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK37900.2 - 1.8e-05 24.7 12.4 0.00022 21.3 0.7 4.8 5 0 0 5 5 5 2 Zinc-finger of C2H2 type Elf1 PF05129.8 EDK37900.2 - 0.038 13.6 0.4 0.085 12.5 0.3 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Zn_ribbon_recom PF13408.1 EDK37900.2 - 0.067 13.4 0.4 0.067 13.4 0.3 1.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-C2HC_2 PF13913.1 EDK37900.2 - 0.2 11.3 0.1 0.2 11.3 0.1 3.2 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.1 EDK37900.2 - 0.8 9.6 5.8 7.5 6.6 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.10 EDK37900.2 - 0.96 9.2 5.9 38 4.1 4.1 2.8 1 1 0 1 1 1 0 BED zinc finger FYVE PF01363.16 EDK37900.2 - 1.1 9.1 6.3 2.6 8.0 4.3 1.6 1 0 0 1 1 1 0 FYVE zinc finger Bac_surface_Ag PF01103.18 EDK37901.2 - 4.3e-43 148.0 3.5 6.6e-43 147.4 2.4 1.3 1 0 0 1 1 1 1 Surface antigen DFP PF04127.10 EDK37903.2 - 8.2e-17 61.4 0.0 1e-09 38.2 0.0 2.1 1 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Cyclin_N PF00134.18 EDK37904.2 - 5.1e-10 38.9 1.3 3.1e-09 36.4 0.3 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.14 EDK37904.2 - 0.098 12.4 1.3 1.3 8.9 0.2 2.7 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Cyclin_C PF02984.14 EDK37904.2 - 0.18 11.7 4.3 0.66 9.9 0.0 3.4 3 2 0 3 3 3 0 Cyclin, C-terminal domain TRAM_LAG1_CLN8 PF03798.11 EDK37905.2 - 9.1e-37 126.5 27.5 9.1e-37 126.5 19.0 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 EDK37905.2 - 1.3e-21 75.8 0.2 1.3e-21 75.8 0.1 2.0 2 0 0 2 2 2 1 TRAM1-like protein Aa_trans PF01490.13 EDK37906.2 - 2.8e-95 319.1 36.4 3.3e-95 318.9 25.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Phage_holin_1 PF04531.8 EDK37906.2 - 2.7 8.1 5.4 1.8 8.7 1.3 2.5 2 0 0 2 2 2 0 Bacteriophage holin Kinesin PF00225.18 EDK37907.2 - 3.3e-109 364.6 0.0 4.4e-109 364.2 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain AAA_33 PF13671.1 EDK37907.2 - 0.038 13.8 0.6 0.49 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.4 EDK37907.2 - 0.059 12.3 5.0 0.1 11.5 3.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Rick_17kDa_Anti PF05433.10 EDK37908.1 - 7.1e-06 25.5 11.8 7.1e-06 25.5 8.2 2.4 2 0 0 2 2 2 1 Glycine zipper 2TM domain Sel1 PF08238.7 EDK37909.2 - 3e-42 142.1 29.2 6.4e-07 29.8 0.2 8.3 8 0 0 8 8 8 7 Sel1 repeat UQ_con PF00179.21 EDK37910.2 - 2.2e-27 95.1 0.0 3.2e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EDK37910.2 - 0.016 15.0 0.1 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 RWD domain OHCU_decarbox PF09349.5 EDK37910.2 - 0.027 14.7 1.1 0.1 12.8 0.3 1.9 2 0 0 2 2 2 0 OHCU decarboxylase Methyltransf_23 PF13489.1 EDK37911.2 - 2.8e-16 59.6 0.0 4.1e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK37911.2 - 4.8e-13 48.9 0.0 8.4e-13 48.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK37911.2 - 3e-12 46.8 0.0 9.9e-12 45.2 0.0 1.9 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK37911.2 - 3.3e-11 43.5 0.0 8.7e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK37911.2 - 1.2e-09 38.4 0.0 2.5e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK37911.2 - 3.9e-08 33.8 0.0 6.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK37911.2 - 1e-06 28.0 0.0 2e-06 27.0 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EDK37911.2 - 0.00012 22.0 0.0 0.00065 19.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.1 EDK37911.2 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EDK37911.2 - 0.0025 17.8 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase FmrO PF07091.6 EDK37911.2 - 0.008 15.1 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) MTS PF05175.9 EDK37911.2 - 0.016 14.5 0.0 0.055 12.8 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.8 EDK37911.2 - 0.018 14.1 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NNMT_PNMT_TEMT PF01234.12 EDK37911.2 - 0.085 11.8 0.0 0.26 10.2 0.0 1.6 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family 2OG-Fe_Oxy_2 PF10014.4 EDK37912.2 - 0.00087 18.7 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe dioxygenase Vps5 PF09325.5 EDK37912.2 - 0.0072 15.6 0.8 0.011 15.0 0.6 1.2 1 0 0 1 1 1 1 Vps5 C terminal like Pkinase PF00069.20 EDK37913.2 - 4.9e-33 114.3 0.0 8.5e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK37913.2 - 3e-13 49.4 0.0 4.1e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PIP49_C PF12260.3 EDK37913.2 - 0.037 13.4 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 zf-AN1 PF01428.11 EDK37914.2 - 1.6e-11 43.8 7.6 2.7e-11 43.1 5.3 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger UPF1_Zn_bind PF09416.5 EDK37914.2 - 0.052 13.1 1.4 0.1 12.1 1.0 1.5 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) zf-C5HC2 PF02928.11 EDK37914.2 - 5.3 7.1 7.9 9.9 6.3 5.4 1.4 1 0 0 1 1 1 0 C5HC2 zinc finger RNase_P_p30 PF01876.11 EDK37915.2 - 1.4e-57 193.1 0.1 1.9e-57 192.6 0.1 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Elongin_A PF06881.6 EDK37916.2 - 9.9e-22 77.3 0.1 1.9e-21 76.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A CRAL_TRIO PF00650.15 EDK37917.2 - 8.7e-38 129.3 0.0 1.2e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EDK37917.2 - 6.3e-15 55.0 4.3 3e-14 52.8 3.0 2.2 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain EXOSC1 PF10447.4 EDK37918.2 - 1.5e-34 117.7 0.1 2.7e-34 116.9 0.1 1.4 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.1 EDK37918.2 - 0.1 11.9 2.4 0.37 10.1 1.7 2.1 1 1 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region Globin PF00042.17 EDK37920.2 - 2e-06 28.0 0.0 7.5e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Globin Lin-8 PF03353.10 EDK37921.2 - 1.3 8.1 11.7 2.5 7.3 8.1 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIA PF03153.8 EDK37921.2 - 1.4 8.6 19.0 0.28 11.0 10.8 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit MTBP_N PF14918.1 EDK37921.2 - 1.6 8.0 5.9 3.6 6.9 4.1 1.5 1 0 0 1 1 1 0 MDM2-binding PAT1 PF09770.4 EDK37921.2 - 5.2 5.1 27.2 8.1 4.5 18.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Suf PF05843.9 EDK37921.2 - 9.8 5.8 10.4 18 4.9 7.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ribosomal_S5 PF00333.15 EDK37923.1 - 2e-26 91.5 5.0 2.2e-26 91.3 2.6 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 EDK37923.1 - 1.8e-22 78.4 0.1 3.1e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain CoA_binding_3 PF13727.1 EDK37923.1 - 0.016 15.0 0.2 0.052 13.3 0.0 1.8 1 1 1 2 2 2 0 CoA-binding domain Fusion_gly PF00523.13 EDK37923.1 - 0.073 11.1 0.4 0.095 10.7 0.3 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF806 PF05657.6 EDK37923.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF806) zf-CCCH_2 PF14608.1 EDK37924.2 - 7.9e-15 54.1 75.7 3.2e-05 23.7 2.7 7.6 7 0 0 7 7 7 6 Zinc finger C-x8-C-x5-C-x3-H type Nab2 PF11517.3 EDK37924.2 - 0.017 15.1 0.3 0.029 14.4 0.2 1.3 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) PAT1 PF09770.4 EDK37924.2 - 1.1 7.4 23.9 0.21 9.7 12.8 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Pex14_N PF04695.8 EDK37924.2 - 7.5 6.6 13.3 1.9 8.5 5.1 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FUSC_2 PF13515.1 EDK37925.2 - 5.2e-31 107.2 3.8 5.2e-31 107.2 2.6 2.5 2 0 0 2 2 2 2 Fusaric acid resistance protein-like DUF2421 PF10334.4 EDK37925.2 - 4.7e-08 32.9 0.3 1.2e-07 31.6 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2421) ALMT PF11744.3 EDK37925.2 - 5e-06 25.4 13.4 0.003 16.2 0.6 3.0 3 1 0 3 3 3 2 Aluminium activated malate transporter FUSC PF04632.7 EDK37925.2 - 0.017 13.6 5.5 1.9 6.8 0.0 3.0 2 1 0 2 2 2 0 Fusaric acid resistance protein family ABC1 PF03109.11 EDK37926.2 - 8.5e-32 109.6 0.0 1.6e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family DUF4169 PF13770.1 EDK37926.2 - 1.5 8.8 3.6 2.5 8.0 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) OB_NTP_bind PF07717.11 EDK37927.1 - 6.3e-25 87.2 0.0 1.6e-24 85.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EDK37927.1 - 1.6e-24 85.8 0.1 3.5e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EDK37927.1 - 1.8e-12 46.9 0.0 4.1e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK37927.1 - 5.1e-07 29.3 0.2 1.2e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK37927.1 - 2.2e-05 24.6 0.0 0.00011 22.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 EDK37927.1 - 9.4e-05 21.9 0.1 0.00024 20.6 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 EDK37927.1 - 0.0024 17.6 0.1 0.0052 16.5 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.10 EDK37927.1 - 0.0042 16.9 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ABC_tran PF00005.22 EDK37927.1 - 0.017 15.4 0.0 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_30 PF13604.1 EDK37927.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EDK37927.1 - 0.058 13.3 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain T2SE PF00437.15 EDK37927.1 - 0.073 11.9 0.0 0.14 10.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.1 EDK37927.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 EDK37927.1 - 0.19 11.2 0.0 0.47 10.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arf PF00025.16 EDK37928.1 - 1.1e-65 220.1 0.1 1.2e-65 219.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 EDK37928.1 - 2.1e-13 49.9 0.0 2.3e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 EDK37928.1 - 2.7e-12 46.2 0.0 3.2e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 EDK37928.1 - 6.6e-12 44.8 1.1 5.7e-09 35.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EDK37928.1 - 2.7e-10 39.7 0.0 3.2e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EDK37928.1 - 9.9e-08 32.4 0.0 1.5e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EDK37928.1 - 7.7e-07 29.0 0.0 1.2e-06 28.4 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK37928.1 - 0.00028 20.3 0.1 0.0022 17.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 EDK37928.1 - 0.065 12.5 0.2 1.6 8.0 0.0 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B 6PF2K PF01591.13 EDK37928.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase ArgK PF03308.11 EDK37928.1 - 0.15 10.7 0.2 0.48 9.1 0.0 2.0 2 1 0 2 2 2 0 ArgK protein Rib_5-P_isom_A PF06026.9 EDK37929.2 - 3.7e-56 189.1 0.1 4.5e-56 188.8 0.1 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 EDK37929.2 - 0.00013 21.5 0.1 0.042 13.5 0.0 2.3 1 1 1 2 2 2 2 DeoR C terminal sensor domain CaATP_NAI PF12515.3 EDK37929.2 - 0.043 13.3 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Sugar-bind PF04198.8 EDK37929.2 - 0.11 11.3 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain Ribosomal_S7e PF01251.13 EDK37930.1 - 7.4e-81 270.1 1.5 8.7e-81 269.9 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e SH3_9 PF14604.1 EDK37931.2 - 4.1e-26 90.3 0.2 2.1e-15 56.0 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 EDK37931.2 - 6.8e-25 86.1 0.4 2.5e-13 49.1 0.1 2.8 2 0 0 2 2 2 2 SH3 domain FCH PF00611.18 EDK37931.2 - 1.3e-22 79.7 3.4 4.2e-22 78.1 0.0 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.12 EDK37931.2 - 6e-13 48.0 0.0 2.2e-09 36.6 0.0 2.7 3 0 0 3 3 3 2 Variant SH3 domain SH3_3 PF08239.6 EDK37931.2 - 0.0049 17.0 0.3 0.072 13.2 0.0 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain Peptidase_C6 PF00851.13 EDK37931.2 - 0.033 12.8 5.5 0.0057 15.3 1.4 1.6 2 0 0 2 2 2 0 Helper component proteinase IncA PF04156.9 EDK37931.2 - 5.5 6.5 15.9 1.1 8.7 4.3 2.7 2 1 1 3 3 3 0 IncA protein DUF2183 PF09949.4 EDK37932.2 - 4.1e-33 113.2 0.1 8.1e-33 112.3 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) NmrA PF05368.8 EDK37932.2 - 0.0033 16.7 0.1 0.0053 16.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family zf-CCCH PF00642.19 EDK37933.2 - 6.7e-06 25.6 0.6 6.7e-06 25.6 0.4 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MOR2-PAG1_N PF14222.1 EDK37934.2 - 1.1e-135 453.4 9.9 4.7e-69 233.5 0.4 3.0 3 0 0 3 3 3 2 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 EDK37934.2 - 1e-94 317.2 3.5 1e-94 317.2 2.4 2.6 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 EDK37934.2 - 1.2e-30 105.9 13.1 5.2e-18 64.1 0.2 4.0 1 1 1 3 3 3 3 Cell morphogenesis central region HEAT_2 PF13646.1 EDK37934.2 - 0.0013 18.9 0.1 1.2 9.4 0.0 4.5 4 0 0 4 4 4 1 HEAT repeats Cnd1 PF12717.2 EDK37934.2 - 0.73 9.6 20.0 0.12 12.2 0.1 6.1 4 2 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.3 EDK37936.2 - 2.1e-104 349.5 17.2 2.1e-104 349.5 11.9 4.2 5 1 0 5 5 5 3 RNAPII transcription regulator C-terminal MMS19_N PF14500.1 EDK37936.2 - 1.2e-88 296.8 0.6 1.2e-88 296.8 0.4 2.9 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.1 EDK37936.2 - 0.00012 22.4 2.8 35 5.0 0.1 6.3 4 2 2 6 6 6 1 HEAT-like repeat DUF3625 PF12293.3 EDK37937.2 - 0.031 13.4 0.1 0.065 12.3 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3625) Bunya_G1 PF03557.10 EDK37937.2 - 0.31 8.7 8.1 0.36 8.5 5.6 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 Patched PF02460.13 EDK37937.2 - 0.48 8.2 2.6 0.63 7.8 1.8 1.1 1 0 0 1 1 1 0 Patched family HSP70 PF00012.15 EDK37937.2 - 1.2 6.9 17.7 1.6 6.5 12.3 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF1192 PF06698.6 EDK37937.2 - 1.5 8.6 9.3 0.53 10.1 2.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Glyco_hydro_65m PF03632.10 EDK37937.2 - 9.3 4.8 7.5 12 4.3 5.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain SCP2 PF02036.12 EDK37938.1 - 9.7e-22 77.1 2.4 1.1e-21 77.0 1.7 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 EDK37938.1 - 0.00016 21.6 0.2 0.0002 21.3 0.1 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal DUF1727 PF08353.5 EDK37938.1 - 0.032 13.8 0.0 0.34 10.5 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1727) WD40 PF00400.27 EDK37939.2 - 3e-14 52.2 0.0 2.1e-06 27.3 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.3 EDK37939.2 - 0.035 12.2 0.0 0.092 10.8 0.0 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF3875 PF12991.2 EDK37939.2 - 0.069 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) DUF3834 PF12916.2 EDK37939.2 - 0.1 11.6 0.2 0.35 9.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) Sec34 PF04136.10 EDK37940.2 - 0.012 15.2 4.4 0.072 12.7 0.7 2.3 1 1 0 2 2 2 0 Sec34-like family FlaC_arch PF05377.6 EDK37940.2 - 0.022 14.6 2.8 1.6 8.7 0.0 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Rsbr_N PF08678.5 EDK37940.2 - 0.031 14.1 0.3 0.08 12.8 0.0 1.8 2 0 0 2 2 2 0 Rsbr N terminal HsbA PF12296.3 EDK37940.2 - 0.052 13.4 4.2 0.54 10.1 0.7 3.0 2 1 0 2 2 2 0 Hydrophobic surface binding protein A COG5 PF10392.4 EDK37940.2 - 0.064 13.2 12.3 0.089 12.7 3.0 3.5 1 1 2 3 3 3 0 Golgi transport complex subunit 5 TPR_MLP1_2 PF07926.7 EDK37940.2 - 0.61 9.8 6.3 0.12 12.1 1.8 1.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein E1-E2_ATPase PF00122.15 EDK37941.2 - 5.9e-63 211.9 0.5 5.9e-63 211.9 0.3 2.5 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EDK37941.2 - 1.5e-45 154.9 6.6 1.5e-45 154.9 4.6 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EDK37941.2 - 4e-28 99.3 0.0 2.4e-26 93.4 0.0 3.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK37941.2 - 5.2e-16 58.3 0.1 1.1e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EDK37941.2 - 1e-13 51.8 0.0 4e-13 49.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EDK37941.2 - 3.9e-10 39.0 0.0 1.4e-09 37.2 0.0 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EDK37941.2 - 5.7e-05 22.8 0.2 0.00061 19.4 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rav1p_C PF12234.3 EDK37942.2 - 2.8e-181 603.9 0.4 5.7e-181 602.9 0.3 1.5 1 1 0 1 1 1 1 RAVE protein 1 C terminal MFS_1 PF07690.11 EDK37943.2 - 9.6e-13 47.5 26.7 1.5e-12 46.9 18.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK37943.2 - 2.3e-09 36.9 9.4 2.3e-09 36.9 6.5 2.4 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 Imm38 PF15599.1 EDK37943.2 - 0.058 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 38 Pyridoxal_deC PF00282.14 EDK37944.2 - 3.3e-70 236.4 0.0 4.2e-70 236.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 EDK37944.2 - 4.4e-07 29.3 0.0 5.8e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EDK37944.2 - 0.0037 16.0 0.0 0.0055 15.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V CPSF_A PF03178.10 EDK37945.2 - 5.2e-87 291.9 0.3 1.2e-86 290.6 0.2 1.7 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.4 EDK37945.2 - 9.5e-41 139.4 2.1 9.5e-41 139.4 1.4 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Fork_head PF00250.13 EDK37946.2 - 2.2e-38 130.1 1.3 2.2e-38 130.1 0.9 2.1 2 0 0 2 2 2 1 Fork head domain FHA PF00498.21 EDK37946.2 - 7e-10 38.8 0.1 1.5e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain WD40 PF00400.27 EDK37947.2 - 3.6e-17 61.5 12.5 2.8e-08 33.3 0.2 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.6 EDK37947.2 - 1.5e-05 24.7 1.0 0.0044 16.7 0.6 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 EDK37947.2 - 2.4e-05 23.3 0.2 4.1e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Coatomer WD associated region Cytochrom_D1 PF02239.11 EDK37947.2 - 0.0068 14.7 0.1 0.43 8.8 0.0 2.6 1 1 0 2 2 2 2 Cytochrome D1 heme domain Vps8 PF12816.2 EDK37948.2 - 9.5e-55 184.8 2.2 9.5e-55 184.8 1.5 1.9 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Vps39_1 PF10366.4 EDK37948.2 - 2.8e-05 24.0 3.8 0.019 14.9 0.5 2.8 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 WD40 PF00400.27 EDK37948.2 - 0.00031 20.5 6.8 0.0012 18.6 0.3 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat zf-rbx1 PF12678.2 EDK37948.2 - 0.0039 17.2 1.6 0.014 15.4 1.1 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EDK37948.2 - 0.039 13.6 1.0 0.12 12.1 0.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3639 PF12341.3 EDK37948.2 - 0.22 11.5 4.6 0.54 10.3 3.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3639) zf-RING_5 PF14634.1 EDK37948.2 - 0.6 9.8 6.3 0.056 13.1 0.5 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK37948.2 - 0.69 9.9 7.3 0.12 12.3 1.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK37948.2 - 5.8 6.8 8.7 0.28 11.0 1.6 2.3 2 0 0 2 2 2 0 Ring finger domain Chitin_synth_1N PF08407.6 EDK37949.2 - 0.0002 20.9 0.0 0.00044 19.8 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_1 PF01644.12 EDK37950.1 - 8.2e-27 93.9 0.1 1.4e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.10 EDK37950.1 - 2e-22 79.2 0.0 3.7e-18 65.2 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 EDK37950.1 - 1.5e-17 63.9 6.4 1.1e-16 61.1 4.4 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 EDK37950.1 - 5.5e-12 45.9 0.0 1.2e-11 44.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EDK37950.1 - 0.0026 17.0 0.1 0.022 14.0 0.0 2.3 3 0 0 3 3 3 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EDK37950.1 - 0.05 13.2 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 E1-E2_ATPase PF00122.15 EDK37951.2 - 1e-62 211.2 9.4 1.8e-62 210.4 6.5 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EDK37951.2 - 1e-23 84.8 0.1 2.1e-23 83.8 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK37951.2 - 9.2e-16 58.5 0.0 2.5e-15 57.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK37951.2 - 0.00077 19.1 0.1 0.0016 18.0 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK37951.2 - 0.03 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit DUF4234 PF14018.1 EDK37951.2 - 7.6 6.3 8.6 0.44 10.3 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) RNA_pol_Rpc34 PF05158.7 EDK37952.2 - 4.5e-87 292.2 0.0 5.2e-87 292.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.7 EDK37952.2 - 0.0087 15.8 0.5 0.047 13.5 0.1 2.1 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC eIF_4G1 PF12152.3 EDK37952.2 - 0.014 15.2 0.3 4.2 7.3 0.1 2.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4G1 Rrf2 PF02082.15 EDK37952.2 - 0.022 14.8 0.3 0.052 13.6 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator Ku_PK_bind PF08785.6 EDK37952.2 - 0.046 13.6 1.6 16 5.3 0.1 3.3 3 0 0 3 3 3 0 Ku C terminal domain like RPA_C PF08784.6 EDK37952.2 - 0.055 13.8 0.1 0.14 12.5 0.0 1.7 2 0 0 2 2 2 0 Replication protein A C terminal Phasin_2 PF09361.5 EDK37952.2 - 0.082 12.9 0.4 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Phasin protein TrmB PF01978.14 EDK37952.2 - 0.098 12.3 0.2 0.71 9.6 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB NTR2 PF15458.1 EDK37953.2 - 0.00046 19.5 2.6 0.00046 19.5 1.8 2.5 2 1 0 2 2 2 1 Nineteen complex-related protein 2 DUF4201 PF13870.1 EDK37953.2 - 0.0031 16.9 0.4 0.0052 16.2 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) TMF_DNA_bd PF12329.3 EDK37953.2 - 0.015 15.0 3.3 0.015 15.0 2.3 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF812 PF05667.6 EDK37953.2 - 0.022 13.2 2.9 0.037 12.5 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF812) IncA PF04156.9 EDK37953.2 - 0.027 14.0 4.5 0.037 13.6 1.2 2.0 2 0 0 2 2 2 0 IncA protein NPV_P10 PF05531.7 EDK37953.2 - 0.031 14.5 3.0 0.07 13.3 2.1 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3552 PF12072.3 EDK37953.2 - 0.039 13.1 3.2 0.08 12.1 2.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Cluap1 PF10234.4 EDK37953.2 - 0.082 12.0 4.2 0.65 9.1 0.4 2.1 2 0 0 2 2 2 0 Clusterin-associated protein-1 Myosin_tail_1 PF01576.14 EDK37953.2 - 0.098 10.3 7.1 0.0081 13.9 1.7 1.5 2 0 0 2 2 2 0 Myosin tail Macoilin PF09726.4 EDK37953.2 - 1.3 7.1 8.1 2.2 6.4 5.6 1.3 1 1 0 1 1 1 0 Transmembrane protein TBPIP PF07106.8 EDK37953.2 - 1.6 8.2 6.1 0.76 9.2 0.6 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DivIC PF04977.10 EDK37953.2 - 2.1 7.8 4.5 17 4.9 2.8 2.4 1 1 0 1 1 1 0 Septum formation initiator OTCace_N PF02729.16 EDK37954.2 - 8e-42 142.2 0.3 2.7e-41 140.5 0.1 1.8 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 EDK37954.2 - 4.5e-38 130.5 0.0 8.7e-38 129.6 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Sod_Cu PF00080.15 EDK37955.2 - 5e-15 55.8 0.2 7.7e-15 55.2 0.1 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Epimerase PF01370.16 EDK37956.1 - 6.6e-12 45.3 0.0 7.8e-12 45.1 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK37956.1 - 4.5e-11 41.9 0.0 5.5e-11 41.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK37956.1 - 2.3e-10 40.7 0.3 3.3e-10 40.2 0.2 1.3 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK37956.1 - 2e-09 36.7 0.1 0.00029 19.8 0.0 2.0 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.8 EDK37956.1 - 5.6e-06 25.7 0.5 9.1e-06 25.0 0.3 1.3 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.20 EDK37956.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase F420_oxidored PF03807.12 EDK37956.1 - 0.024 15.0 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.10 EDK37956.1 - 0.029 13.2 0.0 0.038 12.8 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DCP1 PF06058.8 EDK37956.1 - 0.079 13.0 0.0 0.17 11.9 0.0 1.6 1 1 0 1 1 1 0 Dcp1-like decapping family Shikimate_DH PF01488.15 EDK37956.1 - 0.095 12.8 0.0 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF3589 PF12141.3 EDK37957.2 - 2e-172 573.9 0.0 2.5e-172 573.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) WD40 PF00400.27 EDK37958.2 - 3.8e-15 55.0 12.2 5e-08 32.5 0.0 8.1 9 0 0 9 9 9 5 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EDK37958.2 - 0.024 13.4 11.1 0.53 8.9 0.9 4.6 3 2 0 5 5 5 0 Nup133 N terminal like YmzC PF14157.1 EDK37958.2 - 0.043 13.6 0.2 0.26 11.1 0.0 2.4 3 0 0 3 3 3 0 YmzC-like protein tRNA-synt_1 PF00133.17 EDK37959.2 - 9.1e-229 760.4 0.3 1.6e-228 759.6 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EDK37959.2 - 2.9e-27 95.3 0.5 1e-26 93.5 0.1 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EDK37959.2 - 1.4e-18 66.7 1.7 8.8e-08 31.2 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 EDK37959.2 - 0.0033 16.6 0.0 0.0095 15.0 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain DUF1371 PF07115.6 EDK37959.2 - 0.025 14.7 0.2 0.069 13.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1371) tRNA-synt_1_2 PF13603.1 EDK37959.2 - 0.073 12.3 0.1 0.5 9.6 0.0 2.2 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 ATP_bind_3 PF01171.15 EDK37960.2 - 2.9e-46 157.2 0.0 4.4e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.16 EDK37960.2 - 1.4e-05 24.7 0.0 3.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 EDK37960.2 - 0.0023 16.5 0.0 0.0044 15.6 0.0 1.5 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.8 EDK37960.2 - 0.029 13.6 0.0 0.067 12.4 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Peptidase_M1 PF01433.15 EDK37961.2 - 1.7e-12 47.1 2.1 0.0032 16.6 0.1 3.4 3 0 0 3 3 3 3 Peptidase family M1 VPS9 PF02204.13 EDK37962.2 - 3.1e-28 97.8 0.2 7e-28 96.6 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 EDK37962.2 - 9.9e-05 21.7 0.1 0.00025 20.4 0.1 1.6 1 0 0 1 1 1 1 CUE domain Cupin_3 PF05899.7 EDK37963.2 - 1.6e-08 33.8 0.6 2.4e-08 33.2 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.7 EDK37963.2 - 1.2e-06 28.1 0.0 1.5e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_2 PF07883.6 EDK37963.2 - 0.0011 18.4 0.1 0.0016 17.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain CDC37_N PF03234.9 EDK37964.2 - 1.3e-62 211.2 14.3 1.3e-62 211.2 9.9 2.6 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 EDK37964.2 - 2.4e-46 157.3 4.7 2.4e-46 157.3 3.3 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 EDK37964.2 - 8.7e-20 70.4 2.2 3.1e-19 68.6 0.5 2.6 2 0 0 2 2 2 1 Cdc37 C terminal domain CoA_binding_3 PF13727.1 EDK37964.2 - 0.044 13.6 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 CoA-binding domain MbeB_N PF04837.7 EDK37964.2 - 0.064 13.3 0.3 0.064 13.3 0.2 2.5 2 0 0 2 2 2 0 MbeB-like, N-term conserved region DUF4047 PF13256.1 EDK37964.2 - 1.7 8.6 10.4 0.17 11.8 0.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4047) GFO_IDH_MocA PF01408.17 EDK37965.2 - 1.9e-17 63.8 0.9 5.6e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EDK37965.2 - 2.2e-05 24.2 0.0 4.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain RRM_1 PF00076.17 EDK37966.2 - 4.3e-10 39.0 0.1 3.8e-09 36.0 0.0 2.5 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK37966.2 - 3e-08 33.5 0.0 1e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK37966.2 - 0.00014 21.6 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec20 PF03908.8 EDK37967.2 - 3.6e-25 87.4 1.9 1.2e-24 85.8 1.3 1.9 1 0 0 1 1 1 1 Sec20 Peptidase_M49 PF03571.10 EDK37967.2 - 0.0053 14.8 0.9 0.051 11.6 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M49 Med2 PF11214.3 EDK37967.2 - 2.8 8.0 7.1 16 5.5 0.0 2.6 2 0 0 2 2 2 0 Mediator complex subunit 2 NPV_P10 PF05531.7 EDK37967.2 - 4.6 7.5 8.8 0.26 11.5 1.0 2.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Exo_endo_phos PF03372.18 EDK37968.2 - 2.3e-18 67.0 0.0 3.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mob1_phocein PF03637.12 EDK37969.2 - 1e-70 236.9 0.9 1.4e-70 236.5 0.6 1.2 1 0 0 1 1 1 1 Mob1/phocein family YxiJ PF14176.1 EDK37969.2 - 0.15 12.1 0.1 0.15 12.1 0.1 2.2 2 1 0 2 2 2 0 YxiJ-like protein Fe-S_biosyn PF01521.15 EDK37972.2 - 2.8e-19 69.1 0.0 4.3e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Peptidase_M24 PF00557.19 EDK37973.2 - 4.7e-40 137.3 0.0 6.8e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 EDK37973.2 - 5.6e-20 72.1 0.1 1.3e-13 51.5 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain DUF445 PF04286.7 EDK37975.2 - 0.09 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF445) MCM_N PF14551.1 EDK37975.2 - 0.19 12.1 1.0 5.5 7.4 0.1 3.2 2 1 0 2 2 2 0 MCM N-terminal domain Rep_fac-A_C PF08646.5 EDK37976.2 - 4.1e-52 175.7 3.2 7e-48 162.0 0.2 3.0 2 1 1 3 3 3 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 EDK37976.2 - 6e-15 54.8 0.4 1.2e-08 34.6 0.0 4.1 3 1 1 4 4 4 3 OB-fold nucleic acid binding domain DUF223 PF02721.9 EDK37976.2 - 0.00092 19.2 0.3 0.0023 17.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF223 Cys_Met_Meta_PP PF01053.15 EDK37977.1 - 2.9e-130 434.0 0.0 3.3e-130 433.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EDK37977.1 - 0.002 17.1 0.0 0.0029 16.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Dioxygenase_C PF00775.16 EDK37977.1 - 0.025 13.8 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase DegT_DnrJ_EryC1 PF01041.12 EDK37977.1 - 0.11 11.5 0.0 0.35 9.8 0.0 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family 2Fe-2S_thioredx PF01257.14 EDK37978.1 - 3.2e-62 208.4 0.2 3.9e-62 208.1 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Toxin_51 PF15531.1 EDK37978.1 - 0.099 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative toxin 51 WD40 PF00400.27 EDK37979.2 - 7e-36 120.8 12.9 2.8e-07 30.1 0.1 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 EDK37979.2 - 3.6e-07 30.0 0.5 0.17 11.5 0.0 2.8 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Aminotran_1_2 PF00155.16 EDK37980.2 - 3.1e-21 75.7 0.0 4.2e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EDK37980.2 - 0.00058 19.1 0.0 0.0009 18.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.2 EDK37980.2 - 0.034 12.6 0.0 0.063 11.8 0.0 1.4 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase WD40 PF00400.27 EDK37981.2 - 3.8e-22 77.2 14.2 1.5e-05 24.6 0.0 6.7 7 1 0 7 7 7 4 WD domain, G-beta repeat HIRA_B PF09453.5 EDK37981.2 - 4.2e-11 42.0 0.5 1.1e-10 40.7 0.4 1.8 1 0 0 1 1 1 1 HIRA B motif Hira PF07569.6 EDK37981.2 - 1e-10 41.2 0.1 2.4e-10 40.0 0.1 1.6 1 0 0 1 1 1 1 TUP1-like enhancer of split eIF2A PF08662.6 EDK37981.2 - 0.013 15.2 0.0 2.3 7.8 0.0 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A CHD5 PF04420.9 EDK37982.2 - 2.9e-53 179.8 1.6 4e-53 179.3 1.1 1.2 1 0 0 1 1 1 1 CHD5-like protein DUF2252 PF10009.4 EDK37982.2 - 0.012 14.5 0.1 0.016 14.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF2397 PF09660.5 EDK37982.2 - 0.034 12.7 0.1 0.046 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) DUF2681 PF10883.3 EDK37982.2 - 0.1 12.8 2.1 0.2 11.8 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) HALZ PF02183.13 EDK37982.2 - 0.13 11.9 0.3 0.26 11.0 0.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.10 EDK37982.2 - 0.32 10.5 4.8 0.061 12.8 0.6 1.8 2 0 0 2 2 2 0 Septum formation initiator CK_II_beta PF01214.13 EDK37983.2 - 2.8e-69 232.3 0.0 3.6e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.8 EDK37984.2 - 4.9e-16 58.9 4.8 9.7e-16 58.0 3.3 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 EDK37984.2 - 1.2e-06 28.0 0.2 2.2e-05 24.1 0.0 2.7 2 1 0 2 2 2 1 DnaJ domain zf-CCCH PF00642.19 EDK37985.2 - 1.4e-09 37.3 1.3 3e-09 36.3 0.9 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.1 EDK37985.2 - 1.3e-07 31.4 12.0 2.7e-07 30.4 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK37985.2 - 1.9e-06 27.3 6.7 3.5e-06 26.5 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK37985.2 - 3.3e-06 26.8 8.3 6.5e-06 25.8 5.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 EDK37985.2 - 5.2e-06 26.0 11.4 1e-05 25.1 7.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EDK37985.2 - 3.3e-05 23.4 12.0 6.8e-05 22.4 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK37985.2 - 0.00021 21.0 8.4 0.00021 21.0 5.8 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EDK37985.2 - 0.00066 19.3 4.3 0.0034 17.0 3.0 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 EDK37985.2 - 0.016 14.9 3.5 0.033 13.9 2.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.1 EDK37985.2 - 0.021 14.3 5.7 0.05 13.1 4.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.3 EDK37985.2 - 0.11 11.9 6.0 0.23 10.9 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CDC45 PF02724.9 EDK37985.2 - 0.24 9.3 7.8 0.28 9.1 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein FYVE PF01363.16 EDK37985.2 - 4.2 7.3 10.6 13 5.8 4.0 2.7 1 1 1 2 2 2 0 FYVE zinc finger DUF4112 PF13430.1 EDK37986.2 - 3.3e-28 97.7 0.1 4.4e-28 97.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) CTP_transf_2 PF01467.21 EDK37987.2 - 5.7e-19 68.7 0.0 1.5e-08 34.8 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase FAD_syn PF06574.7 EDK37987.2 - 3.6e-05 23.4 0.0 0.005 16.4 0.0 2.3 2 0 0 2 2 2 2 FAD synthetase HABP4_PAI-RBP1 PF04774.10 EDK37988.2 - 0.0023 18.3 1.1 0.0032 17.9 0.8 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family ATE_C PF04377.10 EDK37989.2 - 1.5e-48 164.0 0.9 1.5e-48 164.0 0.7 2.1 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 EDK37989.2 - 7.2e-27 93.0 1.8 4.8e-26 90.3 1.5 2.1 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.1 EDK37989.2 - 0.14 12.1 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TFIIF_beta PF02270.10 EDK37990.2 - 8.3e-99 330.8 0.2 1.1e-98 330.4 0.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Tau95 PF09734.4 EDK37990.2 - 0.0012 18.2 0.2 0.0037 16.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit Ribosomal_L38e PF01781.13 EDK37991.1 - 4.5e-29 100.0 3.2 5.7e-29 99.6 2.2 1.2 1 0 0 1 1 1 1 Ribosomal L38e protein family ResB PF05140.9 EDK37991.1 - 0.014 13.9 0.1 0.014 13.9 0.1 1.0 1 0 0 1 1 1 0 ResB-like family DUF1664 PF07889.7 EDK37991.1 - 0.15 11.8 0.6 0.17 11.7 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Prp18 PF02840.10 EDK37992.2 - 2e-32 112.0 0.4 2e-32 112.0 0.2 2.3 2 1 1 3 3 3 1 Prp18 domain GalP_UDP_tr_C PF02744.12 EDK37992.2 - 0.038 13.5 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF3513 PF12026.3 EDK37992.2 - 0.39 10.2 8.8 0.6 9.6 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) Pex24p PF06398.6 EDK37993.2 - 1.1e-100 336.9 6.6 1.3e-100 336.7 4.6 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Uricase PF01014.13 EDK37994.1 - 4.1e-72 240.7 0.8 5e-39 133.5 0.2 2.0 2 0 0 2 2 2 2 Uricase EutQ PF06249.7 EDK37994.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ ThiF PF00899.16 EDK37995.2 - 2.9e-40 137.2 0.0 4.6e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.9 EDK37995.2 - 0.0046 16.3 0.1 0.0082 15.5 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.11 EDK37995.2 - 0.0084 15.5 0.1 0.018 14.4 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Saccharop_dh PF03435.13 EDK37995.2 - 0.0096 14.9 1.3 0.08 11.9 0.9 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 EDK37995.2 - 0.017 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.18 EDK37995.2 - 0.024 14.4 0.1 0.043 13.6 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DAO PF01266.19 EDK37995.2 - 0.029 13.2 1.3 0.056 12.3 0.9 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.13 EDK37995.2 - 0.069 12.7 0.1 0.15 11.7 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 EDK37995.2 - 0.12 12.0 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 EDK37995.2 - 0.12 11.3 0.3 0.21 10.5 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.13 EDK37995.2 - 0.12 12.3 0.1 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.22 EDK37995.2 - 0.44 10.9 3.3 0.93 9.9 0.2 2.8 4 0 0 4 4 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF1279 PF06916.8 EDK37996.2 - 6.9e-29 100.0 0.0 1.3e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Bac_small_YrzI PF09501.5 EDK37996.2 - 0.011 15.5 1.1 0.023 14.5 0.7 1.5 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) Ribosomal_L50 PF10501.4 EDK37996.2 - 0.057 13.3 0.4 0.11 12.4 0.1 1.6 2 0 0 2 2 2 0 Ribosomal subunit 39S PCDO_beta_N PF12391.3 EDK37996.2 - 0.11 11.9 0.2 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal 60KD_IMP PF02096.15 EDK37996.2 - 0.14 11.8 0.6 0.25 10.9 0.4 1.5 1 1 0 1 1 1 0 60Kd inner membrane protein Mito_carr PF00153.22 EDK37997.2 - 1.8e-58 194.2 0.1 1.1e-21 76.3 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein NDT80_PhoG PF05224.7 EDK37998.2 - 2e-64 217.0 0.3 2e-64 217.0 0.2 1.7 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family Glucan_synthase PF02364.10 EDK37999.2 - 0 1044.6 2.1 0 1044.2 1.4 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 EDK37999.2 - 1.1e-33 115.5 1.2 2.5e-33 114.4 0.8 1.6 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.9 EDK38001.2 - 4.3e-146 485.8 10.9 5.7e-146 485.4 7.5 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EDK38001.2 - 2.1e-26 92.1 2.2 5.7e-26 90.8 1.6 1.8 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.13 EDK38001.2 - 1e-06 28.1 1.6 2.7e-06 26.8 1.1 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 EDK38001.2 - 0.0013 17.6 0.4 0.0024 16.8 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Gsf2 PF11055.3 EDK38002.2 - 1.1e-158 527.6 0.1 1.3e-158 527.4 0.1 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 Meth_synt_2 PF01717.13 EDK38003.1 - 1.5e-143 477.6 0.0 3.8e-138 459.8 0.0 2.5 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 EDK38003.1 - 2e-122 408.3 0.0 1.2e-111 372.9 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain DUF3502 PF12010.3 EDK38003.1 - 0.012 15.5 0.2 0.91 9.4 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) gp12-short_mid PF09089.5 EDK38003.1 - 0.12 12.3 0.0 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 Phage short tail fibre protein gp12, middle domain SEP PF08059.8 EDK38004.2 - 5.7e-26 90.6 0.1 1.3e-25 89.5 0.0 1.6 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 EDK38004.2 - 1.4e-17 63.5 0.2 3.5e-17 62.2 0.0 1.8 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.1 EDK38004.2 - 6.3e-11 41.6 0.1 1.1e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain DUF667 PF05018.8 EDK38005.2 - 0.059 12.5 0.2 6.3 5.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF667) LRR_4 PF12799.2 EDK38006.2 - 8e-22 76.4 44.5 3.8e-06 26.3 2.6 11.4 11 2 2 13 13 13 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK38006.2 - 8.1e-22 76.7 34.6 1.3e-09 37.6 0.0 10.0 6 2 5 11 11 11 8 Leucine rich repeat LRR_1 PF00560.28 EDK38006.2 - 3.1e-10 38.6 33.1 0.73 10.1 0.4 13.1 12 3 1 13 13 13 5 Leucine Rich Repeat LRR_7 PF13504.1 EDK38006.2 - 4e-05 23.1 26.8 7.9 7.1 0.0 11.9 13 0 0 13 13 13 3 Leucine rich repeat LRR_6 PF13516.1 EDK38006.2 - 0.0025 17.6 41.2 6.3 7.1 0.2 13.7 16 0 0 16 16 16 2 Leucine Rich repeat FNIP PF05725.7 EDK38006.2 - 0.0043 16.9 19.4 0.083 12.8 0.0 7.3 8 2 1 9 9 9 2 FNIP Repeat DUF3354 PF11834.3 EDK38006.2 - 0.023 14.3 0.0 0.28 10.8 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3354) ketoacyl-synt PF00109.21 EDK38007.1 - 2.8e-19 69.5 0.1 6.1e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.15 EDK38007.1 - 3e-14 52.8 0.0 7e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 EDK38007.1 - 4.1e-12 46.0 0.0 1.1e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 EDK38007.1 - 5.9e-05 23.0 0.0 0.00018 21.4 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK38007.1 - 0.0094 15.6 0.0 0.037 13.6 0.0 2.0 1 0 0 1 1 1 1 KR domain Lact_bio_phlase PF09508.5 EDK38008.2 - 0.043 11.4 0.1 0.057 11.0 0.0 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase Symplekin_C PF12295.3 EDK38009.2 - 0.009 15.9 0.7 0.11 12.3 0.4 2.1 1 1 1 2 2 2 2 Symplekin tight junction protein C terminal UcrQ PF02939.11 EDK38009.2 - 0.16 11.8 0.1 0.35 10.7 0.1 1.5 1 0 0 1 1 1 0 UcrQ family Sec7_N PF12783.2 EDK38010.2 - 2.2e-11 43.4 0.3 4.5e-11 42.4 0.2 1.6 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Sec7 PF01369.15 EDK38010.2 - 0.011 15.3 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 Sec7 domain DUF1981 PF09324.5 EDK38011.2 - 1.1e-33 114.6 7.8 1.3e-32 111.0 1.4 3.7 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) Sec7 PF01369.15 EDK38011.2 - 5.3e-29 101.2 3.4 4.1e-28 98.3 0.2 3.3 3 0 0 3 3 3 1 Sec7 domain Mitovir_RNA_pol PF05919.6 EDK38011.2 - 0.0018 17.2 10.3 0.046 12.6 0.9 3.0 2 2 0 2 2 2 2 Mitovirus RNA-dependent RNA polymerase Stm1_N PF09598.5 EDK38012.1 - 5.2e-17 62.3 1.4 5.2e-17 62.3 1.0 4.2 3 3 1 4 4 4 1 Stm1 HABP4_PAI-RBP1 PF04774.10 EDK38012.1 - 0.009 16.4 7.5 0.009 16.4 5.2 3.1 3 1 1 4 4 4 1 Hyaluronan / mRNA binding family Stb3 PF10330.4 EDK38013.2 - 5.1e-31 106.2 0.1 1.4e-30 104.8 0.0 1.7 2 0 0 2 2 2 1 Putative Sin3 binding protein DUF3678 PF12435.3 EDK38013.2 - 0.0049 16.3 1.0 0.65 9.6 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3678) MCM PF00493.18 EDK38014.2 - 1.1e-131 438.6 0.0 2.3e-131 437.5 0.0 1.5 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 EDK38014.2 - 6.2e-30 104.1 1.0 6.1e-29 100.9 0.2 2.5 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 EDK38014.2 - 1e-07 31.3 0.0 1.6e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EDK38014.2 - 1.2e-07 31.5 0.0 2e-06 27.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) zf-UDP PF14569.1 EDK38014.2 - 0.023 14.4 0.5 0.05 13.3 0.3 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger AAA_3 PF07726.6 EDK38014.2 - 0.025 14.1 0.0 0.081 12.5 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EDK38014.2 - 0.097 12.8 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK38014.2 - 0.11 11.9 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_2 PF13335.1 EDK38014.2 - 0.15 12.4 0.1 0.54 10.6 0.1 2.0 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF202 PF02656.10 EDK38015.2 - 1.2e-18 67.0 0.0 1.2e-18 67.0 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF202) TMEM141 PF15110.1 EDK38015.2 - 0.012 15.9 0.4 0.022 15.0 0.3 1.4 1 0 0 1 1 1 0 TMEM141 protein family PTS_EIIC PF02378.13 EDK38015.2 - 0.02 13.7 1.8 0.023 13.5 1.3 1.2 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Memo PF01875.12 EDK38015.2 - 0.13 11.1 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Memo-like protein SdpI PF13630.1 EDK38015.2 - 0.15 11.7 5.6 0.16 11.6 2.9 1.7 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF4307 PF14155.1 EDK38015.2 - 6.2 6.6 7.3 3.8 7.3 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) SAP PF02037.22 EDK38016.1 - 5.8e-13 47.9 0.1 1.4e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 SAP domain HeH PF12949.2 EDK38016.1 - 0.049 13.1 0.2 0.15 11.6 0.2 1.9 1 1 0 1 1 1 0 HeH/LEM domain DUF2052 PF09747.4 EDK38016.1 - 0.14 12.0 10.2 0.21 11.4 7.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LIN37 PF15306.1 EDK38016.1 - 0.49 10.3 5.9 0.79 9.6 4.1 1.4 1 0 0 1 1 1 0 LIN37 DUF2201_N PF13203.1 EDK38016.1 - 2.1 7.4 8.0 3.3 6.8 5.6 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain Pil1 PF13805.1 EDK38017.2 - 3.8 6.5 5.7 0.21 10.6 0.2 1.5 2 0 0 2 2 2 0 Eisosome component PIL1 Peptidase_M1 PF01433.15 EDK38019.2 - 1.3e-127 426.1 0.7 1.9e-127 425.5 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EDK38019.2 - 8.4e-47 159.9 0.1 1.2e-46 159.4 0.1 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EDK38019.2 - 1.3e-18 67.3 0.2 2.5e-18 66.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily BSP PF04450.7 EDK38019.2 - 0.073 12.5 0.6 0.4 10.1 0.0 2.4 3 0 0 3 3 3 0 Peptidase of plants and bacteria BON PF04972.12 EDK38019.2 - 0.16 11.7 0.8 6 6.6 0.2 2.9 2 0 0 2 2 2 0 BON domain Asn_synthase PF00733.16 EDK38020.1 - 2.7e-68 230.2 0.0 4.2e-68 229.6 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EDK38020.1 - 9.1e-34 115.8 0.0 1.7e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EDK38020.1 - 5.3e-27 94.3 0.0 1.5e-26 92.9 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 EDK38020.1 - 7.5e-07 28.5 0.0 1.9e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 EDK38020.1 - 0.00094 17.9 0.0 0.17 10.5 0.0 2.7 1 1 2 3 3 3 1 Glutamine amidotransferases class-II NAD_synthase PF02540.12 EDK38020.1 - 0.059 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD synthase SAC3_GANP PF03399.11 EDK38021.2 - 3.5e-36 124.6 3.8 4.4e-36 124.3 2.6 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EDK38021.2 - 4.1e-19 68.7 0.2 4.1e-19 68.7 0.2 1.9 3 0 0 3 3 3 1 COP9 signalosome, subunit CSN8 ERF PF04404.7 EDK38021.2 - 0.18 11.3 1.6 1.1 8.7 0.1 2.5 2 1 0 3 3 3 0 ERF superfamily VPS28 PF03997.7 EDK38022.2 - 3.1e-44 150.8 0.1 1.7e-42 145.1 0.0 2.0 1 1 0 1 1 1 1 VPS28 protein Steroid_dh PF02544.11 EDK38024.2 - 1.7e-10 40.8 1.7 1.7e-10 40.8 1.2 2.2 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Transp_cyt_pur PF02133.10 EDK38025.1 - 5.1e-73 246.1 36.9 5.8e-73 245.9 25.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SNARE PF05739.14 EDK38026.1 - 6.6e-12 44.9 3.3 6.6e-12 44.9 2.3 3.0 2 1 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EDK38026.1 - 2.6e-06 27.5 7.7 2.6e-06 27.5 5.3 2.4 3 0 0 3 3 2 2 Syntaxin DUF3753 PF12575.3 EDK38026.1 - 0.0071 16.1 4.9 0.38 10.5 0.4 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3753) DUF4094 PF13334.1 EDK38026.1 - 0.026 14.9 8.0 0.18 12.2 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) GTSE1_N PF15259.1 EDK38026.1 - 0.039 13.9 1.9 0.076 12.9 1.3 1.6 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 DUF805 PF05656.9 EDK38026.1 - 0.089 12.6 0.6 0.12 12.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) EspG PF06872.6 EDK38026.1 - 0.093 11.0 3.9 0.16 10.2 2.7 1.3 1 0 0 1 1 1 0 EspG protein Herpes_US9 PF06072.6 EDK38026.1 - 0.23 11.3 1.0 0.52 10.1 0.7 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF4032 PF13224.1 EDK38026.1 - 0.78 9.4 8.0 2.9 7.5 1.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4032) AAA_13 PF13166.1 EDK38026.1 - 0.99 7.7 19.4 0.22 9.9 9.3 1.9 1 1 1 2 2 2 0 AAA domain DUF3394 PF11874.3 EDK38026.1 - 2.6 7.5 6.7 1.8 8.0 2.2 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF3394) ISG65-75 PF11727.3 EDK38026.1 - 3.9 6.4 14.2 0.96 8.4 4.9 2.3 2 1 0 2 2 2 0 Invariant surface glycoprotein IPK PF03770.11 EDK38027.2 - 3.2e-55 186.8 0.0 3.9e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase ACOX PF01756.14 EDK38027.2 - 0.036 13.4 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA oxidase GTP_EFTU PF00009.22 EDK38028.2 - 6.9e-46 156.0 0.0 1.4e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EDK38028.2 - 8.2e-26 90.0 0.5 1.6e-25 89.1 0.3 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EDK38028.2 - 1.3e-06 28.3 0.1 3.4e-06 27.0 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EDK38028.2 - 0.00015 21.7 0.0 0.00041 20.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Glyco_transf_15 PF01793.11 EDK38029.2 - 3e-52 177.6 11.3 4.2e-52 177.1 7.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF3867 PF12983.2 EDK38029.2 - 0.02 14.8 1.5 0.57 10.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3867) VHS PF00790.14 EDK38030.2 - 1.2e-11 44.4 0.0 2.5e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.9 EDK38030.2 - 0.00012 21.9 0.0 0.00038 20.3 0.0 1.8 1 0 0 1 1 1 1 GAT domain Vps35 PF03635.12 EDK38031.2 - 0.29 9.2 11.9 0.43 8.6 8.2 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 35 SNARE PF05739.14 EDK38032.2 - 7.3e-05 22.3 1.9 0.00014 21.5 1.3 1.5 1 0 0 1 1 1 1 SNARE domain ParA PF10609.4 EDK38033.2 - 3.3e-38 129.4 0.1 8.5e-38 128.1 0.0 1.7 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 EDK38033.2 - 9.6e-17 61.0 0.0 1.5e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 EDK38033.2 - 3.1e-07 29.7 0.1 4.3e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 EDK38033.2 - 3.4e-05 23.0 0.6 0.00021 20.4 0.1 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.1 EDK38033.2 - 6.5e-05 22.9 0.0 0.00059 19.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 EDK38033.2 - 0.0019 17.0 0.1 0.0031 16.3 0.1 1.3 1 0 0 1 1 1 1 ArgK protein AAA_26 PF13500.1 EDK38033.2 - 0.0088 15.6 0.2 0.91 9.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain YhjQ PF06564.7 EDK38033.2 - 0.014 14.7 0.0 0.025 13.9 0.0 1.4 1 1 0 1 1 1 0 YhjQ protein AAA_25 PF13481.1 EDK38033.2 - 0.019 14.3 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 EDK38033.2 - 0.053 12.9 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein APS_kinase PF01583.15 EDK38033.2 - 0.071 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase zf-C4_ClpX PF06689.8 EDK38033.2 - 3.6 7.1 5.7 2 7.9 2.3 1.8 2 0 0 2 2 2 0 ClpX C4-type zinc finger Nop16 PF09420.5 EDK38034.2 - 4.6e-59 199.2 15.5 5.3e-59 199.0 10.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 SIC PF03482.8 EDK38034.2 - 0.0072 15.9 0.4 0.0096 15.5 0.3 1.2 1 0 0 1 1 1 1 sic protein EHN PF06441.7 EDK38034.2 - 0.34 10.8 5.1 0.16 11.9 1.8 1.8 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Fe_hyd_SSU PF02256.12 EDK38034.2 - 0.71 9.9 3.1 1.1 9.3 0.5 2.4 2 1 1 3 3 3 0 Iron hydrogenase small subunit RRM_1 PF00076.17 EDK38035.1 - 1.7e-19 69.1 0.1 2.6e-19 68.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38035.1 - 9.1e-16 57.6 0.0 1.5e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38035.1 - 1.9e-13 49.9 0.0 2.9e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FXR1P_C PF12235.3 EDK38035.1 - 0.33 11.0 9.2 0.6 10.2 6.4 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein C terminal API5 PF05918.6 EDK38035.1 - 0.39 9.1 3.6 0.46 8.9 2.5 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) PMI_typeI PF01238.16 EDK38036.2 - 1.6e-153 511.1 0.0 1.9e-153 510.9 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.14 EDK38036.2 - 0.0017 18.0 0.0 0.081 12.6 0.0 2.5 3 0 0 3 3 3 1 AraC-like ligand binding domain Cupin_2 PF07883.6 EDK38036.2 - 0.0028 17.1 0.0 1.3 8.5 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Thioredoxin PF00085.15 EDK38037.2 - 6.3e-19 67.5 0.9 9.2e-15 54.1 0.1 3.9 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 EDK38037.2 - 2.4e-06 27.5 2.0 0.00019 21.3 0.2 3.7 2 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_4 PF13462.1 EDK38037.2 - 0.07 13.1 0.1 0.07 13.1 0.1 3.5 4 1 1 5 5 5 0 Thioredoxin Neur_chan_memb PF02932.11 EDK38037.2 - 0.091 12.6 0.1 0.35 10.7 0.1 2.0 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mito_carr PF00153.22 EDK38038.2 - 4.2e-72 237.9 3.3 1.5e-25 88.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Aa_trans PF01490.13 EDK38039.2 - 7.2e-29 100.4 29.6 7.2e-29 100.4 20.5 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 EDK38039.2 - 0.00014 20.7 15.5 0.00014 20.7 10.7 2.4 1 1 1 3 3 3 1 Tryptophan/tyrosine permease family Arc_PepC_II PF06847.6 EDK38039.2 - 0.03 14.7 0.5 0.064 13.6 0.4 1.6 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II NAD_binding_10 PF13460.1 EDK38040.1 - 7.2e-15 55.4 0.0 1.1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK38040.1 - 4e-06 26.4 0.0 0.00084 18.8 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.8 EDK38040.1 - 3.8e-05 23.0 0.0 6.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.19 EDK38040.1 - 0.0061 16.8 0.0 0.013 15.7 0.0 1.5 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EDK38040.1 - 0.0077 14.9 0.1 0.06 12.0 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.11 EDK38040.1 - 0.018 14.4 0.0 0.047 13.1 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA RmlD_sub_bind PF04321.12 EDK38040.1 - 0.029 13.2 0.0 0.5 9.1 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain F420_oxidored PF03807.12 EDK38040.1 - 0.03 14.7 0.0 0.057 13.8 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 EDK38040.1 - 0.035 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short PF00106.20 EDK38040.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Ldh_1_N PF00056.18 EDK38040.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.15 EDK38040.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 3HCDH_N PF02737.13 EDK38040.1 - 0.16 11.5 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF866 PF05907.8 EDK38041.1 - 1.2e-40 138.6 0.4 1.4e-40 138.3 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Ribosomal_L44 PF00935.14 EDK38041.1 - 0.0022 17.9 1.7 0.39 10.7 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L44 SprT-like PF10263.4 EDK38041.1 - 0.0081 15.8 0.0 0.0097 15.5 0.0 1.3 1 0 0 1 1 1 1 SprT-like family Terminase_GpA PF05876.7 EDK38041.1 - 0.013 13.8 0.1 0.016 13.6 0.1 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Zn_Tnp_IS1595 PF12760.2 EDK38041.1 - 0.36 10.6 5.0 1.2 9.0 3.5 1.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-UBR PF02207.15 EDK38041.1 - 0.59 9.8 5.0 1.5 8.6 0.2 2.2 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Cytochrom_c3_2 PF14537.1 EDK38041.1 - 0.78 10.1 4.4 4.3 7.7 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c3 C1_4 PF07975.7 EDK38041.1 - 1.3 9.0 4.8 11 6.1 3.5 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain zf-DNL PF05180.7 EDK38041.1 - 3.8 7.2 8.1 73 3.1 5.6 2.4 1 1 0 1 1 1 0 DNL zinc finger Mito_carr PF00153.22 EDK38042.2 - 5.9e-42 141.2 6.2 3.4e-16 58.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ArfGap PF01412.13 EDK38043.2 - 6.4e-40 135.5 2.9 6.4e-40 135.5 2.0 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Cyt-b5 PF00173.23 EDK38044.2 - 2.4e-21 75.2 0.1 3.5e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rsa3 PF14615.1 EDK38045.2 - 8.2e-19 66.6 0.7 8.2e-19 66.6 0.5 1.7 2 0 0 2 2 2 1 Ribosome-assembly protein 3 IFT57 PF10498.4 EDK38045.2 - 0.063 12.0 9.6 0.074 11.7 6.6 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Pox_A11 PF05061.8 EDK38045.2 - 0.066 12.2 5.8 0.11 11.5 4.0 1.4 1 1 0 1 1 1 0 Poxvirus A11 Protein SR-25 PF10500.4 EDK38045.2 - 0.21 11.0 17.8 0.32 10.4 12.4 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 EDK38045.2 - 0.29 11.2 12.9 0.61 10.1 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) TMEM51 PF15345.1 EDK38045.2 - 0.29 10.7 7.3 0.38 10.4 5.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2052 PF09747.4 EDK38045.2 - 0.88 9.4 11.5 1.4 8.8 8.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Vfa1 PF08432.5 EDK38045.2 - 2.8 7.9 12.9 3.3 7.7 8.6 1.3 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PBP1_TM PF14812.1 EDK38045.2 - 2.8 8.2 7.0 6.1 7.2 4.8 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SOBP PF15279.1 EDK38045.2 - 3 8.1 6.4 3.6 7.8 4.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF966 PF06136.8 EDK38045.2 - 3.9 6.7 11.4 4.5 6.5 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Mem_trans PF03547.13 EDK38045.2 - 4.1 5.5 5.4 4.7 5.4 3.8 1.1 1 0 0 1 1 1 0 Membrane transport protein SHNi-TPR PF10516.4 EDK38046.2 - 8.6e-19 66.4 1.7 8.6e-19 66.4 1.2 2.3 2 0 0 2 2 2 1 SHNi-TPR TPR_11 PF13414.1 EDK38046.2 - 4.2e-06 26.3 6.1 0.0075 15.8 1.4 2.5 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EDK38046.2 - 0.00021 20.9 6.2 0.061 13.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38046.2 - 0.0066 16.3 6.7 0.066 13.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK38046.2 - 0.072 12.7 2.8 2 8.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 EDK38046.2 - 1.1 9.1 4.1 12 5.9 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38046.2 - 5 7.9 9.1 10 6.9 1.6 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat CNH PF00780.17 EDK38047.2 - 2.1e-30 106.1 0.3 1.9e-29 102.9 0.1 2.5 2 1 0 2 2 2 1 CNH domain PH_5 PF15405.1 EDK38047.2 - 1.1e-09 38.3 0.0 2.9e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 EDK38047.2 - 0.00012 22.1 0.6 0.00057 20.0 0.1 2.4 2 0 0 2 2 2 1 PH domain adh_short PF00106.20 EDK38048.1 - 4.8e-27 94.9 0.2 6.2e-27 94.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK38048.1 - 2.5e-24 86.3 0.0 3e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK38048.1 - 3.8e-15 56.0 0.2 5.5e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EDK38048.1 - 0.00065 18.6 0.1 0.00088 18.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 EDK38048.1 - 0.0011 18.4 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EDK38048.1 - 0.02 13.8 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein Thioredoxin_8 PF13905.1 EDK38048.1 - 0.024 14.7 0.1 0.075 13.1 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like ELFV_dehydrog PF00208.16 EDK38048.1 - 0.031 13.8 0.2 0.043 13.3 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3HCDH_N PF02737.13 EDK38048.1 - 0.082 12.5 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1776 PF08643.5 EDK38048.1 - 0.097 11.7 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF3782 PF12644.2 EDK38048.1 - 0.12 12.1 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) EF-hand_1 PF00036.27 EDK38049.2 - 9.7e-27 90.2 17.2 7.2e-07 28.0 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 EDK38049.2 - 5.9e-24 83.9 4.7 1.7e-11 44.0 1.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EDK38049.2 - 5.5e-21 72.5 12.8 2.7e-05 23.6 0.0 4.6 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 EDK38049.2 - 9.5e-19 65.8 19.4 4.2e-05 22.6 0.1 4.7 4 1 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 EDK38049.2 - 1.7e-12 46.7 17.6 0.00018 21.0 0.0 4.6 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.2 EDK38049.2 - 1.2e-05 24.9 10.0 0.067 12.9 0.6 3.9 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 EDK38049.2 - 3.3e-05 23.8 0.0 0.06 13.3 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 EDK38049.2 - 0.0043 16.9 0.1 3.2 7.7 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain VCBS PF13517.1 EDK38049.2 - 0.41 11.0 3.5 10 6.5 0.2 2.6 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DivIC PF04977.10 EDK38050.2 - 0.34 10.4 2.3 0.42 10.1 0.3 2.2 2 0 0 2 2 2 0 Septum formation initiator AAA_11 PF13086.1 EDK38051.2 - 8.7e-68 228.4 1.9 8.7e-68 228.4 1.3 2.6 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 EDK38051.2 - 7.5e-66 221.3 2.1 1e-65 220.9 0.0 2.4 3 0 0 3 3 3 1 AAA domain SEN1_N PF12726.2 EDK38051.2 - 6.2e-53 179.9 1.4 1.5e-52 178.7 1.0 1.6 1 0 0 1 1 1 1 SEN1 N terminal AAA_19 PF13245.1 EDK38051.2 - 1.1e-10 41.0 0.0 2.6e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EDK38051.2 - 8.7e-07 28.7 0.0 0.00043 19.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 EDK38051.2 - 8e-06 25.5 0.3 0.16 11.4 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 EDK38051.2 - 0.027 13.8 0.0 1.5 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain Fungal_trans_2 PF11951.3 EDK38052.2 - 2.3e-43 148.2 0.5 2.3e-43 148.2 0.4 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38052.2 - 1.5e-09 37.5 11.5 2.8e-09 36.7 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RWD PF05773.17 EDK38053.2 - 5.1e-16 58.5 0.8 9.5e-16 57.7 0.6 1.5 1 0 0 1 1 1 1 RWD domain IBR PF01485.16 EDK38053.2 - 7.6e-16 57.7 37.1 7.8e-10 38.4 4.9 3.9 3 1 1 4 4 4 2 IBR domain zf-C3HC4 PF00097.20 EDK38053.2 - 7.7e-05 22.2 7.6 7.7e-05 22.2 5.2 4.3 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK38053.2 - 0.00029 20.6 5.4 0.00029 20.6 3.7 4.3 3 1 1 4 4 4 2 Ring finger domain zf-C3HC4_2 PF13923.1 EDK38053.2 - 0.0051 16.8 9.7 0.0051 16.8 6.7 4.8 5 0 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) COPIIcoated_ERV PF07970.7 EDK38054.2 - 4.5e-38 131.1 0.1 8.6e-38 130.1 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EDK38054.2 - 1.9e-20 72.6 0.2 4.2e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pex24p PF06398.6 EDK38055.2 - 5.4e-108 360.9 1.4 6.8e-108 360.6 0.9 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin YrhC PF14143.1 EDK38055.2 - 1.7 8.6 6.9 1.6 8.7 1.4 2.8 2 1 0 2 2 2 0 YrhC-like protein Pkinase PF00069.20 EDK38056.2 - 2.3e-54 184.3 0.3 8.4e-54 182.4 0.2 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38056.2 - 5.1e-26 91.3 0.1 1e-25 90.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.15 EDK38056.2 - 0.0075 15.8 0.2 0.28 10.7 0.0 2.4 1 1 1 2 2 2 1 Choline/ethanolamine kinase Sugarporin_N PF11471.3 EDK38057.1 - 0.12 12.0 0.7 0.12 12.0 0.5 2.1 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension ABC_membrane_2 PF06472.10 EDK38058.2 - 2e-64 217.4 0.1 2.8e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 EDK38058.2 - 2.8e-20 72.9 0.0 5.3e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EDK38058.2 - 0.0003 20.8 0.1 0.0013 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EDK38058.2 - 0.0016 17.8 0.0 0.0042 16.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 EDK38058.2 - 0.0018 18.6 0.1 0.018 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 EDK38058.2 - 0.02 14.5 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SMC_N PF02463.14 EDK38058.2 - 0.053 12.7 0.0 0.13 11.4 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EDK38058.2 - 0.064 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK38058.2 - 0.066 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.12 EDK38058.2 - 0.09 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.13 EDK38058.2 - 0.092 12.2 0.1 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.2 EDK38058.2 - 0.11 11.9 0.1 0.7 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_22 PF13401.1 EDK38058.2 - 0.13 12.4 0.0 0.41 10.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EDK38058.2 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pept_tRNA_hydro PF01195.14 EDK38059.1 - 4.6e-52 176.1 0.2 5.2e-52 176.0 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase CoA_binding_2 PF13380.1 EDK38060.2 - 3.2e-29 101.4 0.0 3.9e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Fungal_trans PF04082.13 EDK38061.2 - 6.9e-06 25.1 0.7 6.9e-06 25.1 0.5 2.6 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38061.2 - 2.1e-05 24.3 9.4 3.9e-05 23.4 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.8 EDK38061.2 - 9.6 5.9 25.6 1.5 8.6 13.3 2.4 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SH3_1 PF00018.23 EDK38062.2 - 4.6e-16 57.9 0.2 1.2e-15 56.5 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK38062.2 - 1.5e-14 53.2 0.2 2.9e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK38062.2 - 4.1e-12 45.3 0.2 9.9e-12 44.1 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain BAR PF03114.13 EDK38062.2 - 5.8e-09 35.8 12.9 9.2e-09 35.1 8.9 1.3 1 0 0 1 1 1 1 BAR domain DUF1413 PF07205.6 EDK38062.2 - 0.027 13.9 0.4 0.073 12.6 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) IFT46_B_C PF12317.3 EDK38062.2 - 0.18 11.1 3.7 0.12 11.7 0.6 2.0 2 1 1 3 3 3 0 Intraflagellar transport complex B protein 46 C terminal DUF342 PF03961.8 EDK38062.2 - 4.2 5.6 8.8 0.99 7.7 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF342) STAT_alpha PF01017.15 EDK38062.2 - 5.8 6.5 14.3 2.2 7.9 0.4 2.7 1 1 1 2 2 2 0 STAT protein, all-alpha domain LRR_4 PF12799.2 EDK38063.2 - 2.4e-11 42.9 7.5 2.1e-06 27.2 0.1 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK38063.2 - 5.1e-08 32.5 1.0 5.1e-08 32.5 0.7 2.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 EDK38063.2 - 0.0035 17.1 7.6 8.8 6.8 0.1 4.9 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_7 PF13504.1 EDK38063.2 - 0.0057 16.6 4.9 5 7.7 0.2 4.0 3 0 0 3 3 3 1 Leucine rich repeat OB_NTP_bind PF07717.11 EDK38064.2 - 6.7e-26 90.3 0.0 5.1e-25 87.5 0.0 2.3 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 EDK38064.2 - 7.5e-22 77.2 0.1 7.6e-21 74.0 0.0 2.7 3 0 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 EDK38064.2 - 1.1e-12 47.5 0.0 2.9e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EDK38064.2 - 6.8e-09 35.9 0.1 1.8e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 EDK38064.2 - 5.9e-08 32.3 0.2 1.2e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 EDK38064.2 - 0.00024 20.1 0.0 0.00069 18.6 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.1 EDK38064.2 - 0.0019 17.7 0.1 0.0038 16.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 EDK38064.2 - 0.003 17.0 0.5 0.01 15.3 0.3 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_14 PF13173.1 EDK38064.2 - 0.013 15.4 0.0 0.16 11.8 0.0 2.8 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EDK38064.2 - 0.017 14.5 0.1 4.7 6.5 0.0 2.7 3 0 0 3 3 3 0 AAA-like domain Arch_ATPase PF01637.13 EDK38064.2 - 0.022 14.4 0.1 0.022 14.4 0.1 2.1 2 0 0 2 2 2 0 Archaeal ATPase AAA_16 PF13191.1 EDK38064.2 - 0.037 14.0 0.3 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.1 EDK38064.2 - 0.051 13.9 0.0 0.051 13.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 EDK38064.2 - 0.054 13.2 0.1 0.28 10.9 0.0 2.2 2 0 0 2 2 2 0 Part of AAA domain ABC_tran PF00005.22 EDK38064.2 - 0.12 12.6 0.0 0.12 12.6 0.0 2.7 2 1 0 2 2 1 0 ABC transporter TruB_N PF01509.13 EDK38064.2 - 0.36 10.9 3.8 0.83 9.7 2.6 1.5 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) PRK PF00485.13 EDK38065.2 - 6.9e-61 205.1 0.0 9.7e-61 204.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 EDK38065.2 - 2.3e-35 121.6 0.0 4.4e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.1 EDK38065.2 - 3.4e-08 34.3 0.0 2.8e-07 31.3 0.0 2.5 3 1 0 3 3 2 1 AAA domain AAA_18 PF13238.1 EDK38065.2 - 9.9e-08 32.3 0.0 2.1e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EDK38065.2 - 2e-05 24.4 0.0 4.2e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EDK38065.2 - 2.9e-05 23.2 0.0 5.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.7 EDK38065.2 - 0.0014 18.2 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein KAP_NTPase PF07693.9 EDK38065.2 - 0.0037 16.3 0.0 0.0043 16.0 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain AAA_22 PF13401.1 EDK38065.2 - 0.0059 16.7 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 EDK38065.2 - 0.016 14.9 0.0 0.094 12.4 0.0 2.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EDK38065.2 - 0.018 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Miro PF08477.8 EDK38065.2 - 0.018 15.5 0.1 1.4 9.4 0.0 2.7 1 1 1 2 2 2 0 Miro-like protein CoaE PF01121.15 EDK38065.2 - 0.038 13.3 0.0 1.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_5 PF07728.9 EDK38065.2 - 0.041 13.6 0.0 0.18 11.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 EDK38065.2 - 0.042 13.5 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase Aminotran_1_2 PF00155.16 EDK38066.2 - 9.1e-42 143.2 0.0 1.7e-41 142.4 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EDK38066.2 - 0.016 14.4 0.0 0.031 13.4 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Glyco_hydro_20 PF00728.17 EDK38066.2 - 0.017 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain UspB PF10625.4 EDK38066.2 - 0.071 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Universal stress protein B (UspB) XPC-binding PF09280.6 EDK38066.2 - 0.13 11.7 0.1 5.6 6.4 0.0 3.0 3 0 0 3 3 3 0 XPC-binding domain Gaa1 PF04114.9 EDK38067.1 - 9.6e-91 304.9 18.8 6.3e-89 298.9 13.1 2.1 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component Apc4 PF12896.2 EDK38068.2 - 3.3e-66 222.6 3.5 3.3e-66 222.6 2.4 1.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 Apc4_WD40 PF12894.2 EDK38068.2 - 2e-09 36.7 0.1 9.6e-09 34.6 0.1 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 EDK38068.2 - 0.028 14.3 2.3 2 8.4 0.0 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat eIF2A PF08662.6 EDK38068.2 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Ribosomal_L1 PF00687.16 EDK38069.2 - 6.3e-26 91.0 0.2 7.8e-26 90.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Med25_SD1 PF11235.3 EDK38069.2 - 0.0028 17.9 0.7 0.0028 17.9 0.5 1.6 2 0 0 2 2 2 1 Mediator complex subunit 25 synapsin 1 RhoGAP PF00620.22 EDK38070.2 - 1.2e-11 44.4 0.2 8.1e-05 22.2 0.1 2.4 2 0 0 2 2 2 2 RhoGAP domain RP-C_C PF11800.3 EDK38070.2 - 0.93 9.1 5.3 2 8.0 3.7 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region cNMP_binding PF00027.24 EDK38071.2 - 3.2e-38 129.4 0.1 1.4e-19 69.7 0.0 2.7 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain LRR_6 PF13516.1 EDK38071.2 - 1.5e-14 52.3 10.4 0.52 10.5 0.1 9.7 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.2 EDK38071.2 - 9.1e-08 31.5 1.4 0.44 10.2 0.1 5.5 3 2 1 4 4 4 2 Leucine Rich repeats (2 copies) F-box PF00646.28 EDK38071.2 - 6.7e-07 28.8 2.6 3e-05 23.5 0.3 4.1 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.2 EDK38071.2 - 1.5e-06 27.8 2.8 2.5e-06 27.0 0.2 2.7 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.28 EDK38071.2 - 3e-06 26.5 14.7 27 5.3 0.1 9.9 11 1 0 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.1 EDK38071.2 - 6.9e-05 22.5 9.7 0.04 13.6 1.7 5.6 4 1 0 5 5 5 1 Leucine rich repeat LRR_7 PF13504.1 EDK38071.2 - 0.0083 16.1 14.9 16 6.2 0.2 8.1 9 0 0 9 9 9 1 Leucine rich repeat SUI1 PF01253.17 EDK38072.2 - 2e-15 56.3 0.0 5.1e-15 55.0 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.13 EDK38072.2 - 0.042 13.5 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 SWIB/MDM2 domain PUA PF01472.15 EDK38072.2 - 0.045 13.4 0.0 0.094 12.4 0.0 1.5 1 0 0 1 1 1 0 PUA domain PIG-S PF10510.4 EDK38073.1 - 3e-130 435.3 3.7 3.5e-130 435.1 2.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein DUF2121 PF09894.4 EDK38073.1 - 0.12 11.6 1.0 0.29 10.4 0.5 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) Endonuclease_NS PF01223.18 EDK38074.2 - 1.9e-57 194.2 0.0 2.3e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Acyl_transf_1 PF00698.16 EDK38075.2 - 7.3e-83 278.5 0.0 7.7e-82 275.1 0.0 2.7 4 0 0 4 4 4 1 Acyl transferase domain MaoC_dehydratas PF01575.14 EDK38075.2 - 5e-40 135.6 0.0 1e-39 134.6 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 EDK38075.2 - 5.6e-32 109.3 0.1 1.4e-31 108.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 EDK38075.2 - 1.7e-14 53.7 0.0 6.2e-14 51.9 0.0 2.0 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase NMO PF03060.10 EDK38075.2 - 6.5e-05 22.2 0.2 0.00049 19.3 0.1 2.3 1 1 0 1 1 1 1 Nitronate monooxygenase RelB_N PF12910.2 EDK38075.2 - 0.06 12.7 0.0 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin stability system N-terminal His_Phos_2 PF00328.17 EDK38076.2 - 1.1e-127 426.1 0.1 1.4e-127 425.8 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 EDK38076.2 - 1.7e-06 27.6 0.0 3.8e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EDK38076.2 - 0.1 12.4 0.6 0.37 10.6 0.0 2.2 3 0 0 3 3 3 0 ATP-grasp domain Pribosyltran_N PF13793.1 EDK38077.2 - 1.1e-39 134.7 0.0 2.5e-39 133.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 EDK38077.2 - 1.7e-38 132.1 0.5 2.2e-29 102.5 0.0 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 EDK38077.2 - 8.9e-05 22.2 0.2 0.001 18.8 0.1 2.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRR1 PF07985.7 EDK38078.2 - 6.7e-22 77.1 0.0 1.4e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 SRR1 HSF_DNA-bind PF00447.12 EDK38079.2 - 8.9e-37 125.4 4.4 1.7e-36 124.4 3.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 EDK38079.2 - 6.3e-26 90.5 0.2 1.8e-25 89.1 0.2 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Spermine_synth PF01564.12 EDK38079.2 - 0.014 14.3 0.1 0.028 13.3 0.1 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase Ets PF00178.17 EDK38079.2 - 0.092 12.8 0.3 0.18 11.9 0.2 1.4 1 0 0 1 1 1 0 Ets-domain Tmemb_cc2 PF10267.4 EDK38079.2 - 0.14 10.7 0.5 0.19 10.3 0.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein GIY-YIG PF01541.19 EDK38080.2 - 1.2e-08 35.1 0.0 1.8e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.4 EDK38080.2 - 0.017 15.4 0.0 0.036 14.4 0.0 1.7 1 1 0 1 1 1 0 T5orf172 domain Nudix_N_2 PF14803.1 EDK38080.2 - 0.59 9.8 0.0 0.59 9.8 0.0 2.7 3 0 0 3 3 3 0 Nudix N-terminal Glyco_hydro_31 PF01055.21 EDK38081.2 - 5.7e-149 496.6 0.5 7.9e-149 496.2 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EDK38081.2 - 3.3e-21 74.9 0.3 2e-20 72.3 0.1 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like BRE1 PF08647.6 EDK38082.2 - 1.5e-23 82.5 8.8 1.5e-23 82.5 6.1 8.0 4 2 5 9 9 5 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 EDK38082.2 - 4.1e-07 29.9 9.4 7.2e-07 29.1 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK38082.2 - 9.2e-07 28.4 7.5 1.6e-06 27.6 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK38082.2 - 1.4e-05 24.6 9.0 2.7e-05 23.7 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38082.2 - 5.1e-05 22.9 10.0 9.3e-05 22.0 7.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 EDK38082.2 - 0.00094 18.9 9.0 0.0018 18.0 6.3 1.5 1 0 0 1 1 1 1 Ring finger domain UPF0184 PF03670.8 EDK38082.2 - 0.016 15.3 4.9 0.016 15.3 3.4 5.6 4 2 4 8 8 7 0 Uncharacterised protein family (UPF0184) zf-RING_3 PF14369.1 EDK38082.2 - 0.056 13.4 2.3 0.15 12.1 1.6 1.7 1 0 0 1 1 1 0 zinc-finger zf-C2H2 PF00096.21 EDK38082.2 - 0.092 13.1 0.1 0.092 13.1 0.1 3.0 3 0 0 3 3 2 0 Zinc finger, C2H2 type zf-RING_UBOX PF13445.1 EDK38082.2 - 0.096 12.4 3.9 0.4 10.4 2.7 2.2 1 0 0 1 1 1 0 RING-type zinc-finger DUF1272 PF06906.6 EDK38082.2 - 0.12 12.2 4.7 0.32 10.8 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Prok-RING_4 PF14447.1 EDK38082.2 - 0.14 11.7 3.2 0.32 10.5 2.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 EDK38082.2 - 0.17 11.7 6.5 0.35 10.7 4.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 EDK38082.2 - 0.21 11.4 3.6 0.45 10.3 2.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Surfac_D-trimer PF09006.6 EDK38082.2 - 0.31 10.8 4.5 32 4.3 0.1 4.4 4 0 0 4 4 3 0 Lung surfactant protein D coiled-coil trimerisation zf-RING_4 PF14570.1 EDK38082.2 - 0.37 10.4 5.9 0.76 9.4 4.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DivIC PF04977.10 EDK38082.2 - 0.68 9.4 66.1 0.1 12.1 2.3 9.1 4 2 5 9 9 9 0 Septum formation initiator zinc_ribbon_4 PF13717.1 EDK38082.2 - 1.8 8.3 9.1 2.5 7.8 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Gin PF10764.4 EDK38082.2 - 2.1 8.1 4.5 3.3 7.4 0.9 2.6 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin FYVE PF01363.16 EDK38082.2 - 2.3 8.1 10.4 24 4.8 7.3 2.5 1 1 0 1 1 1 0 FYVE zinc finger zinc_ribbon_5 PF13719.1 EDK38082.2 - 2.8 7.5 9.3 3.3 7.3 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Bromodomain PF00439.20 EDK38083.1 - 5.8e-17 61.3 0.1 1e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain Dus PF01207.12 EDK38084.2 - 1.1e-78 264.2 0.0 1.2e-78 264.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 EDK38084.2 - 9.4e-05 21.4 0.1 0.00085 18.3 0.1 2.0 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Oxidored_FMN PF00724.15 EDK38084.2 - 0.0003 19.8 0.0 0.00048 19.2 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family TMP-TENI PF02581.12 EDK38084.2 - 0.00088 18.4 0.1 0.0019 17.3 0.1 1.6 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI Resolvase PF00239.16 EDK38084.2 - 0.0052 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Resolvase, N terminal domain His_biosynth PF00977.16 EDK38084.2 - 0.026 13.7 0.1 0.11 11.6 0.1 2.0 2 1 0 2 2 2 0 Histidine biosynthesis protein NMO PF03060.10 EDK38084.2 - 0.13 11.3 0.2 0.19 10.8 0.1 1.3 1 1 0 1 1 1 0 Nitronate monooxygenase SMC_N PF02463.14 EDK38085.1 - 1.5e-37 129.0 0.0 1.5e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK38085.1 - 1e-06 28.9 0.0 1.2e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 EDK38085.1 - 0.0051 15.9 0.0 0.0071 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 EDK38085.1 - 0.0053 16.6 0.1 0.013 15.4 0.0 1.7 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 EDK38086.2 - 2e-29 102.4 37.3 2e-29 102.4 25.9 3.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EDK38086.2 - 8.8e-26 90.2 0.3 9.6e-24 83.6 0.0 3.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EDK38086.2 - 9.3e-09 35.9 32.6 9.3e-09 35.9 22.6 7.5 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.1 EDK38086.2 - 3.8e-05 23.1 0.0 8.3e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 EDK38086.2 - 3.5 6.7 46.5 1.3 8.0 4.0 6.2 2 2 3 6 6 6 0 Reovirus sigma C capsid protein IncA PF04156.9 EDK38086.2 - 5.7 6.4 136.9 2.1 7.8 13.1 6.9 3 2 5 8 8 8 0 IncA protein AAA_21 PF13304.1 EDK38086.2 - 9.4 6.1 38.8 0.11 12.3 13.3 4.4 3 1 0 3 3 3 0 AAA domain RNA_polI_A14 PF08203.6 EDK38087.2 - 2.1e-21 75.9 1.3 4e-21 75.0 0.0 2.1 2 1 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 SprA-related PF12118.3 EDK38087.2 - 0.0041 16.4 17.3 0.0043 16.4 12.0 1.1 1 0 0 1 1 1 1 SprA-related family GAGA_bind PF06217.7 EDK38087.2 - 0.44 10.4 26.6 0.6 10.0 18.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Ribosomal_L34 PF00468.12 EDK38088.2 - 1.6e-21 75.6 6.9 1.6e-21 75.6 4.8 1.5 1 1 0 1 1 1 1 Ribosomal protein L34 DnaJ PF00226.26 EDK38091.2 - 2.7e-26 91.0 1.3 4.4e-26 90.3 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 EDK38091.2 - 7e-21 73.9 0.5 9.3e-18 63.9 0.0 3.2 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 EDK38091.2 - 1.8e-14 53.5 15.8 3e-14 52.8 11.0 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EDK38091.2 - 0.0028 17.3 2.6 1.1 8.9 0.8 2.3 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family Cytochrom_c3_2 PF14537.1 EDK38091.2 - 0.43 10.9 8.7 0.049 13.9 3.0 1.8 2 0 0 2 2 2 0 Cytochrome c3 Stc1 PF12898.2 EDK38091.2 - 0.93 9.5 9.2 3.1 7.9 1.0 2.5 1 1 1 2 2 2 0 Stc1 domain DUF1356 PF07092.7 EDK38091.2 - 1 8.4 3.6 7.1 5.7 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1356) Aldo_ket_red PF00248.16 EDK38092.2 - 1.5e-59 201.2 0.0 1.8e-59 200.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family T4_Gp59_C PF08994.5 EDK38092.2 - 0.019 15.1 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term HTH_Tnp_Tc5 PF03221.11 EDK38093.2 - 6e-13 48.4 0.1 1.6e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 EDK38093.2 - 0.00014 21.1 0.1 0.00031 20.0 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain ApoO PF09769.4 EDK38094.2 - 0.23 11.1 2.5 2 8.0 1.7 2.3 1 1 0 1 1 1 0 Apolipoprotein O Allantoicase PF03561.10 EDK38095.2 - 1.5e-101 336.2 0.7 4.4e-56 188.5 0.1 2.0 2 0 0 2 2 2 2 Allantoicase repeat Methyltransf_16 PF10294.4 EDK38096.2 - 1.8e-18 66.6 0.5 4.1e-18 65.4 0.1 1.6 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 EDK38096.2 - 2.1e-05 23.9 0.0 3.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 EDK38096.2 - 0.00029 21.4 0.0 0.00043 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK38096.2 - 0.004 16.7 0.0 0.0075 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 EDK38096.2 - 0.0084 15.2 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.7 EDK38096.2 - 0.012 16.0 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 EDK38096.2 - 0.037 13.7 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AA_permease PF00324.16 EDK38097.2 - 2.3e-119 398.8 46.3 2.8e-119 398.5 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK38097.2 - 5.3e-36 124.0 47.3 6.6e-36 123.7 32.8 1.1 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.11 EDK38098.2 - 1.9e-36 125.5 59.1 1.7e-32 112.5 41.6 3.0 1 1 0 2 2 2 2 Major Facilitator Superfamily WBP-1 PF11669.3 EDK38098.2 - 0.0061 16.6 0.1 0.4 10.7 0.0 2.8 2 0 0 2 2 2 1 WW domain-binding protein 1 Sugar_tr PF00083.19 EDK38098.2 - 4.3 5.7 45.2 0.66 8.4 16.0 3.1 1 1 0 2 2 2 0 Sugar (and other) transporter SAGA-Tad1 PF12767.2 EDK38099.2 - 1.2e-31 110.2 0.7 1.3e-31 110.1 0.5 1.0 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit SAGA-Tad1 PF12767.2 EDK38100.1 - 1.1e-16 61.3 0.0 1.6e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit IncA PF04156.9 EDK38101.2 - 0.00016 21.3 14.2 0.00016 21.3 9.8 2.9 1 1 1 2 2 2 1 IncA protein DivIC PF04977.10 EDK38101.2 - 0.00051 19.4 2.6 0.00051 19.4 1.8 5.6 3 2 2 5 5 5 2 Septum formation initiator FlaC_arch PF05377.6 EDK38101.2 - 0.00074 19.3 3.3 0.00074 19.3 2.3 4.0 3 1 1 4 4 4 1 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.3 EDK38101.2 - 0.0016 18.2 9.2 0.0016 18.2 6.3 4.5 1 1 3 4 4 2 1 TATA element modulatory factor 1 DNA binding Filament PF00038.16 EDK38101.2 - 0.011 15.1 41.9 0.019 14.4 29.1 1.3 1 0 0 1 1 1 0 Intermediate filament protein ATG16 PF08614.6 EDK38101.2 - 0.096 12.4 46.7 0.033 14.0 16.2 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TBPIP PF07106.8 EDK38101.2 - 0.13 11.8 38.2 4.2 6.8 5.7 3.4 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ATP-synt_ab_N PF02874.18 EDK38101.2 - 0.21 11.8 0.6 3.6 7.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain Reo_sigmaC PF04582.7 EDK38101.2 - 0.3 10.2 10.5 0.25 10.4 0.9 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Prominin PF05478.6 EDK38101.2 - 0.35 8.3 24.2 0.56 7.6 4.4 2.9 1 1 2 3 3 3 0 Prominin Seryl_tRNA_N PF02403.17 EDK38101.2 - 0.65 10.0 37.3 0.14 12.1 9.1 3.9 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF812 PF05667.6 EDK38101.2 - 0.73 8.2 40.3 0.13 10.7 7.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Snapin_Pallidin PF14712.1 EDK38101.2 - 1.9 8.8 30.5 0.84 9.9 2.2 4.7 1 1 5 6 6 6 0 Snapin/Pallidin Syntaxin-6_N PF09177.6 EDK38101.2 - 2.3 8.6 26.6 0.6 10.5 3.5 4.2 1 1 3 4 4 4 0 Syntaxin 6, N-terminal DUF869 PF05911.6 EDK38101.2 - 2.3 6.3 42.6 1.4 7.0 8.5 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) Spc7 PF08317.6 EDK38101.2 - 4.1 5.9 38.9 0.23 10.1 15.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF972 PF06156.8 EDK38101.2 - 6.6 7.1 35.6 1.1 9.6 6.2 4.0 1 1 2 3 3 3 0 Protein of unknown function (DUF972) APG6 PF04111.7 EDK38101.2 - 8.9 5.2 50.0 0.093 11.7 10.1 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 V-SNARE_C PF12352.3 EDK38102.2 - 3e-18 65.6 2.2 3e-18 65.6 1.5 2.2 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 EDK38102.2 - 1.3e-08 34.8 2.2 1.3e-08 34.8 1.5 2.2 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.8 EDK38102.2 - 0.00094 18.8 0.3 0.00094 18.8 0.2 2.0 1 1 1 2 2 2 1 Sec20 Mnd1 PF03962.10 EDK38102.2 - 0.2 11.3 2.9 0.25 10.9 2.0 1.2 1 0 0 1 1 1 0 Mnd1 family DUF4071 PF13281.1 EDK38102.2 - 0.26 10.0 3.0 0.21 10.4 0.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4071) Fusion_gly PF00523.13 EDK38102.2 - 0.47 8.4 3.1 0.17 9.9 0.2 1.6 2 0 0 2 2 2 0 Fusion glycoprotein F0 Glyco_hydro_63 PF03200.11 EDK38103.2 - 6.5e-09 34.2 3.2 3.6e-06 25.1 0.0 3.4 3 1 0 3 3 3 2 Mannosyl oligosaccharide glucosidase F-box-like PF12937.2 EDK38104.2 - 0.0012 18.4 0.0 0.0052 16.4 0.0 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EDK38104.2 - 0.034 13.7 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 F-box domain zf-C2H2_4 PF13894.1 EDK38105.2 - 1.6e-05 24.8 15.8 0.028 14.7 0.3 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK38105.2 - 0.0024 18.0 6.1 0.033 14.4 0.3 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.21 EDK38105.2 - 0.0052 17.0 25.1 0.049 13.9 1.2 4.2 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 EDK38105.2 - 0.076 13.1 0.1 0.076 13.1 0.0 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Seipin PF06775.9 EDK38106.2 - 1.5e-06 27.8 2.5 0.00011 21.8 1.7 2.2 1 1 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF1765 PF08578.5 EDK38107.2 - 4.5e-40 136.5 5.6 1.1e-39 135.3 3.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Phage_Coat_B PF05356.6 EDK38107.2 - 0.13 11.9 0.0 0.41 10.3 0.0 1.8 1 0 0 1 1 1 0 Phage Coat protein B Cytotoxic PF09000.5 EDK38107.2 - 0.2 11.7 0.1 0.42 10.6 0.1 1.4 1 0 0 1 1 1 0 Cytotoxic AA_permease_C PF13906.1 EDK38107.2 - 0.41 10.5 2.8 5.5 6.9 0.3 2.8 2 0 0 2 2 2 0 C-terminus of AA_permease Choline_kinase PF01633.15 EDK38108.2 - 8e-54 182.4 0.2 1.2e-53 181.8 0.2 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 EDK38108.2 - 1.8e-11 43.3 0.2 5.2e-11 41.8 0.2 1.8 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 EDK38108.2 - 5.6e-08 32.7 0.3 1.5e-07 31.3 0.2 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Phage_tail_L PF05100.7 EDK38108.2 - 0.058 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Phage minor tail protein L Corona_nucleoca PF00937.13 EDK38108.2 - 3.9 6.3 6.4 7.5 5.3 4.4 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein WD40 PF00400.27 EDK38109.2 - 5e-30 102.2 16.9 1.4e-08 34.3 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat TRAP-delta PF05404.7 EDK38109.2 - 0.081 12.3 0.0 0.16 11.4 0.0 1.4 1 1 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) KH_3 PF13014.1 EDK38110.2 - 6.4e-24 83.1 1.6 4.3e-11 42.1 0.0 5.2 6 0 0 6 6 6 3 KH domain KH_1 PF00013.24 EDK38110.2 - 8.5e-13 47.7 5.9 2.8e-08 33.2 0.1 5.4 7 0 0 7 7 7 2 KH domain ELO PF01151.13 EDK38111.2 - 7.7e-76 254.6 12.2 9.1e-76 254.4 8.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Sugar_tr PF00083.19 EDK38112.2 - 1.6e-96 323.6 17.8 2e-96 323.3 12.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK38112.2 - 3.2e-35 121.4 43.1 8.7e-31 106.9 14.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EDK38112.2 - 0.0018 18.0 1.4 0.037 13.8 0.2 3.3 3 0 0 3 3 3 1 MFS_1 like family DUF1228 PF06779.9 EDK38112.2 - 0.076 13.0 4.5 0.76 9.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1228) OATP PF03137.15 EDK38112.2 - 0.42 8.6 7.6 0.2 9.6 3.2 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Ribosomal_L7Ae PF01248.21 EDK38114.1 - 8.5e-23 79.6 0.5 1.5e-22 78.9 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EDK38114.1 - 0.0028 17.4 0.1 0.0046 16.8 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 RRM_1 PF00076.17 EDK38115.2 - 7.5e-26 89.5 6.4 1.6e-15 56.4 0.5 3.8 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38115.2 - 4.1e-22 77.9 0.5 6.7e-14 51.6 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38115.2 - 4.8e-12 45.5 0.3 9.9e-07 28.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EDK38115.2 - 0.00012 21.7 1.4 0.72 9.6 0.1 3.3 2 1 0 2 2 2 2 Limkain b1 DUF1675 PF07897.6 EDK38115.2 - 0.18 11.6 12.5 0.014 15.2 5.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) DUF566 PF04484.7 EDK38115.2 - 3.5 7.0 9.6 5.5 6.4 6.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) ABC_membrane PF00664.18 EDK38116.2 - 3.9e-16 59.2 4.9 1.1e-14 54.5 0.7 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region Permease PF02405.11 EDK38116.2 - 0.02 14.4 0.1 0.043 13.2 0.1 1.5 1 0 0 1 1 1 0 Permease ABC_tran PF00005.22 EDK38117.2 - 2.5e-59 199.4 0.0 2.9e-35 121.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 EDK38117.2 - 1.2e-29 103.6 8.9 1.2e-29 103.6 6.2 1.5 2 0 0 2 2 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 EDK38117.2 - 4.7e-12 46.4 2.9 8.2e-06 25.9 0.1 3.7 2 2 0 2 2 2 2 AAA domain SMC_N PF02463.14 EDK38117.2 - 1.3e-09 37.6 4.8 0.015 14.4 1.4 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EDK38117.2 - 4.1e-09 37.0 11.6 1.9e-05 25.0 0.2 2.8 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.1 EDK38117.2 - 7.5e-09 34.9 0.3 0.00049 19.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 EDK38117.2 - 1.6e-06 28.2 0.1 0.011 15.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 EDK38117.2 - 1.2e-05 24.6 0.0 0.049 12.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 EDK38117.2 - 2.4e-05 23.8 0.0 0.052 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 EDK38117.2 - 2.6e-05 24.7 0.1 0.29 11.6 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_22 PF13401.1 EDK38117.2 - 3.5e-05 23.9 0.6 0.37 10.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 EDK38117.2 - 5.1e-05 23.2 0.1 0.074 13.0 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SE PF00437.15 EDK38117.2 - 0.00018 20.4 0.5 0.037 12.9 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.1 EDK38117.2 - 0.00031 21.5 0.0 1.1 10.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EDK38117.2 - 0.00038 19.9 0.0 0.21 11.0 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Zeta_toxin PF06414.7 EDK38117.2 - 0.00051 19.2 0.1 0.79 8.7 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_10 PF12846.2 EDK38117.2 - 0.00053 19.5 0.0 0.045 13.1 0.0 2.7 3 0 0 3 3 2 1 AAA-like domain AAA PF00004.24 EDK38117.2 - 0.0014 18.8 0.3 2.4 8.3 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.1 EDK38117.2 - 0.0017 17.5 0.1 0.44 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.18 EDK38117.2 - 0.0024 17.6 0.5 0.46 10.2 0.0 2.8 3 0 0 3 3 2 1 Dynamin family DUF87 PF01935.12 EDK38117.2 - 0.0026 17.6 0.1 0.55 9.9 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 MobB PF03205.9 EDK38117.2 - 0.0026 17.4 0.2 2.9 7.5 0.0 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 EDK38117.2 - 0.011 15.3 0.4 5 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 EDK38117.2 - 0.011 15.5 0.3 5.9 6.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain Arch_ATPase PF01637.13 EDK38117.2 - 0.013 15.2 0.4 0.3 10.7 0.0 2.6 2 1 0 2 2 2 0 Archaeal ATPase ATP_bind_1 PF03029.12 EDK38117.2 - 0.017 14.6 0.4 20 4.6 0.0 3.5 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein ResIII PF04851.10 EDK38117.2 - 0.023 14.5 0.0 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.9 EDK38117.2 - 0.026 14.2 0.0 12 5.5 0.0 3.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EDK38117.2 - 0.031 14.0 0.2 0.57 9.9 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain Pox_A32 PF04665.7 EDK38117.2 - 0.032 13.5 0.1 0.45 9.7 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein DUF815 PF05673.8 EDK38117.2 - 0.032 13.1 0.0 0.43 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.1 EDK38117.2 - 0.033 14.5 1.5 5.5 7.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 EDK38117.2 - 0.043 13.2 2.6 0.74 9.2 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Adeno_IVa2 PF02456.10 EDK38117.2 - 0.053 12.1 0.3 2.1 6.8 0.0 2.8 3 0 0 3 3 3 0 Adenovirus IVa2 protein IstB_IS21 PF01695.12 EDK38117.2 - 0.055 12.8 0.0 1.9 7.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein ArgK PF03308.11 EDK38117.2 - 0.065 12.0 0.0 0.13 10.9 0.0 1.4 1 0 0 1 1 1 0 ArgK protein TrwB_AAD_bind PF10412.4 EDK38117.2 - 0.086 11.4 0.0 6.6 5.2 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 EDK38117.2 - 0.088 12.3 0.1 16 5.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.1 EDK38117.2 - 0.097 12.5 0.1 8.2 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2953 PF11167.3 EDK38117.2 - 1.3 8.9 5.7 0.35 10.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2953) AA_permease_2 PF13520.1 EDK38118.2 - 3.5e-65 220.2 40.2 4.4e-65 219.8 27.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK38118.2 - 1.7e-14 53.0 33.4 1.9e-14 52.8 22.6 1.3 1 1 0 1 1 1 1 Amino acid permease Asp PF00026.18 EDK38120.2 - 7.5e-60 202.8 0.4 8.9e-60 202.5 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK38120.2 - 4.6e-09 36.4 0.2 8.2e-07 29.1 0.1 2.3 2 0 0 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EDK38120.2 - 7.6e-06 26.3 0.0 0.05 14.1 0.0 2.8 2 0 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 EDK38120.2 - 6.4e-05 22.5 0.0 0.019 14.4 0.0 2.7 3 0 0 3 3 3 2 Xylanase inhibitor C-terminal RVP PF00077.15 EDK38120.2 - 0.029 14.3 0.0 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 EDK38120.2 - 0.08 12.7 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease CLTH PF10607.4 EDK38122.2 - 6.5e-30 103.7 1.0 9.5e-30 103.1 0.7 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 EDK38122.2 - 4.3e-07 29.4 0.2 1e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 LisH PCP_red PF08369.5 EDK38122.2 - 0.066 13.0 0.1 0.3 11.0 0.0 2.0 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit GATA PF00320.22 EDK38123.2 - 8.2e-08 31.4 7.0 8.2e-08 31.4 4.9 2.1 2 0 0 2 2 2 1 GATA zinc finger Zip PF02535.17 EDK38123.2 - 1.7 7.5 6.2 2.4 7.0 4.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ubiquitin PF00240.18 EDK38124.2 - 9.9e-22 76.1 0.1 1.8e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EDK38124.2 - 7.5e-10 38.3 0.0 1.1e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.26 EDK38124.2 - 2.6e-09 36.6 0.0 2.6e-09 36.6 0.0 2.4 3 0 0 3 3 3 1 UBA/TS-N domain Rad60-SLD_2 PF13881.1 EDK38124.2 - 7.7e-05 22.5 0.1 0.00022 21.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EDK38124.2 - 0.00013 22.1 0.0 0.00021 21.4 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 EDK38124.2 - 0.00035 20.7 0.0 0.00085 19.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain DUF4261 PF14080.1 EDK38124.2 - 0.13 12.1 0.0 0.59 9.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4261) XPC-binding PF09280.6 EDK38124.2 - 5.1 6.6 14.9 16 5.0 8.8 2.3 1 1 1 2 2 2 0 XPC-binding domain TAF8_C PF10406.4 EDK38125.2 - 4.6e-22 77.8 4.1 1.5e-21 76.1 1.5 2.8 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.8 EDK38125.2 - 0.00031 20.3 0.2 0.00093 18.8 0.0 1.8 2 0 0 2 2 2 1 Bromodomain associated PsiA PF06952.6 EDK38125.2 - 4.2 6.3 7.0 19 4.1 4.9 2.0 1 1 0 1 1 1 0 PsiA protein Sugar_tr PF00083.19 EDK38126.2 - 4.5e-83 279.3 25.9 5.5e-83 279.0 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK38126.2 - 6.2e-22 77.7 23.8 1.2e-19 70.3 14.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK38126.2 - 0.0001 20.6 5.1 0.0001 20.6 3.5 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF2306 PF10067.4 EDK38126.2 - 1.2 9.3 18.0 2.2 8.4 2.2 3.0 2 1 1 3 3 3 0 Predicted membrane protein (DUF2306) NIF PF03031.13 EDK38128.2 - 4.6e-28 97.8 0.4 1.4e-26 93.1 0.0 2.5 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.21 EDK38128.2 - 3.9e-08 33.3 0.2 1.2e-07 31.7 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EDK38128.2 - 1.1e-05 25.1 0.1 3.8e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain SUR7 PF06687.7 EDK38129.2 - 7.1e-73 244.6 10.2 8.3e-73 244.4 7.1 1.0 1 0 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.1 EDK38129.2 - 0.0019 17.9 7.9 0.0019 17.9 5.4 2.3 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.15 EDK38129.2 - 0.0073 15.9 1.8 0.0073 15.9 1.2 2.1 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Prominin PF05478.6 EDK38129.2 - 0.019 12.5 1.2 0.071 10.6 0.2 2.1 2 0 0 2 2 2 0 Prominin Tetraspannin PF00335.15 EDK38129.2 - 0.34 10.1 23.4 0.061 12.5 3.8 3.1 1 1 2 3 3 3 0 Tetraspanin family Amastin PF07344.6 EDK38129.2 - 2.9 7.4 14.6 0.96 9.0 6.5 2.6 2 1 0 2 2 2 0 Amastin surface glycoprotein DUF4064 PF13273.1 EDK38129.2 - 7.2 6.7 12.7 18 5.4 0.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) Coatomer_WDAD PF04053.9 EDK38130.2 - 5.4e-08 32.0 0.4 1.2e-07 30.9 0.2 1.5 1 1 1 2 2 2 1 Coatomer WD associated region PQQ_3 PF13570.1 EDK38130.2 - 0.055 13.7 0.1 30 5.0 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain eIF2A PF08662.6 EDK38130.2 - 0.059 13.0 0.0 0.6 9.7 0.0 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A PGM_PMM_I PF02878.11 EDK38131.2 - 1.1e-35 122.1 0.5 2.1e-33 114.7 0.4 2.5 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EDK38131.2 - 2.9e-21 75.7 0.0 1.7e-20 73.2 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 EDK38131.2 - 2.4e-17 62.9 0.0 4.9e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 EDK38131.2 - 9.5e-07 28.7 0.0 3.5e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Anp1 PF03452.9 EDK38132.2 - 5.7e-125 415.9 0.0 6.9e-125 415.6 0.0 1.1 1 0 0 1 1 1 1 Anp1 Zn_clus PF00172.13 EDK38133.2 - 2.5e-05 24.0 10.1 7.1e-05 22.6 7.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.18 EDK38134.2 - 5e-18 65.4 2.2 8.5e-18 64.6 1.5 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK38134.2 - 3.4e-06 27.0 0.5 6.7e-06 26.1 0.4 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.18 EDK38135.2 - 4.7e-13 49.0 0.0 4.7e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic aspartyl protease Yip1 PF04893.12 EDK38136.2 - 0.0057 16.1 0.2 0.0088 15.5 0.2 1.2 1 0 0 1 1 1 1 Yip1 domain Hexapep PF00132.19 EDK38137.1 - 1.3e-12 46.6 7.5 8.3e-11 40.8 2.0 2.8 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EDK38137.1 - 1.3e-09 37.4 5.6 1.5e-08 34.0 0.8 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.19 EDK38138.2 - 4.3e-12 44.9 8.1 4.7e-10 38.5 3.0 3.0 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.3 EDK38138.2 - 2.1e-11 43.6 0.0 5.5e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Maltose acetyltransferase Hexapep_2 PF14602.1 EDK38138.2 - 2.6e-08 33.2 7.2 2.4e-07 30.1 1.5 2.7 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Kelch_3 PF13415.1 EDK38140.2 - 1e-06 28.7 4.7 2.2e-06 27.6 0.1 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.1 EDK38140.2 - 8.4e-06 25.7 7.4 0.00024 21.1 0.0 4.2 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.1 EDK38140.2 - 1.2e-05 24.9 2.0 0.0033 17.1 0.1 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 EDK38140.2 - 5.8e-05 22.6 0.8 0.03 14.0 0.1 3.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 EDK38140.2 - 0.00097 18.6 6.7 0.055 13.0 0.8 4.7 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 EDK38140.2 - 0.025 14.5 0.2 2.5 8.1 0.0 3.2 2 1 0 2 2 2 0 Kelch motif DUF3812 PF12757.2 EDK38141.2 - 4.9e-17 62.1 0.7 4.9e-17 62.1 0.5 10.4 6 2 4 11 11 11 1 Protein of unknown function (DUF3812) Reo_sigmaC PF04582.7 EDK38141.2 - 0.091 11.9 9.6 0.023 13.9 3.4 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein ADH_N PF08240.7 EDK38142.1 - 1.8e-29 101.6 0.6 3.4e-29 100.7 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK38142.1 - 0.00012 21.6 0.5 0.0002 20.9 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase RRM_1 PF00076.17 EDK38143.1 - 9.1e-23 79.6 0.1 1.1e-14 53.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38143.1 - 2.7e-18 65.6 0.0 4.9e-09 36.0 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38143.1 - 0.00075 19.2 0.0 0.14 12.0 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK38143.1 - 0.043 13.5 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif CDK5_activator PF03261.10 EDK38143.1 - 1.9 7.7 5.6 2.7 7.2 3.9 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein RabGAP-TBC PF00566.13 EDK38144.2 - 0.013 14.9 8.8 0.18 11.2 0.1 2.9 3 0 0 3 3 3 0 Rab-GTPase-TBC domain ENTH PF01417.15 EDK38145.2 - 1.7e-31 108.6 0.4 2.7e-31 108.0 0.3 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 EDK38145.2 - 0.034 12.8 0.0 0.053 12.2 0.0 1.4 1 0 0 1 1 1 0 ANTH domain ubiquitin PF00240.18 EDK38146.1 - 2.4e-202 654.7 39.2 2.1e-33 113.5 0.6 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.3 EDK38146.1 - 7.1e-116 378.0 35.7 8.2e-19 67.0 0.5 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EDK38146.1 - 1.2e-34 118.4 20.4 0.00028 21.0 0.1 8.0 6 6 0 6 6 6 6 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EDK38146.1 - 1.5e-31 109.2 4.9 0.0015 18.2 0.0 6.0 6 0 0 6 6 6 6 Telomere stability and silencing DUF2407 PF10302.4 EDK38146.1 - 2.4e-19 69.3 7.3 0.23 11.6 0.0 6.2 1 1 4 6 6 6 6 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 EDK38146.1 - 2.6e-19 69.1 8.4 0.23 11.3 0.0 7.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 EDK38146.1 - 7.4e-16 57.9 0.0 2.6 8.1 0.0 6.9 6 0 0 6 6 6 6 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 EDK38146.1 - 2.9e-08 33.4 12.7 8.2 6.4 0.0 6.2 6 0 0 6 6 6 6 GLUT4 regulating protein TUG FlgD_ig PF13860.1 EDK38146.1 - 4.8e-06 26.2 11.7 23 4.7 0.0 6.2 6 0 0 6 6 6 0 FlgD Ig-like domain Big_3_3 PF13750.1 EDK38146.1 - 2e-05 24.0 0.1 82 2.5 0.0 5.7 6 0 0 6 6 6 0 Bacterial Ig-like domain (group 3) ACT_4 PF13291.1 EDK38146.1 - 0.00013 22.2 2.8 1.7e+02 2.6 0.0 6.0 6 0 0 6 6 6 0 ACT domain Plexin_cytopl PF08337.7 EDK38146.1 - 0.00016 20.1 23.6 4 5.6 0.2 7.8 7 5 0 7 7 7 5 Plexin cytoplasmic RasGAP domain Tash_PEST PF07708.6 EDK38146.1 - 0.03 14.2 47.6 5.5 7.0 1.2 6.4 6 0 0 6 6 6 0 Tash protein PEST motif GABP-alpha PF11620.3 EDK38146.1 - 0.05 13.5 14.7 82 3.2 0.1 5.9 6 0 0 6 6 6 0 GA-binding protein alpha chain FERM_N PF09379.5 EDK38146.1 - 0.59 10.2 22.7 75 3.4 0.1 8.1 6 6 0 6 6 6 0 FERM N-terminal domain DUF3781 PF12636.2 EDK38146.1 - 1.8 8.5 15.0 1.7e+02 2.2 0.1 5.9 6 0 0 6 6 6 0 Protein of unknown function (DUF3781) HEAT PF02985.17 EDK38147.2 - 0.003 17.5 0.4 0.97 9.6 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat Ecm29 PF13001.2 EDK38148.2 - 4.1e-127 424.7 2.7 9e-127 423.5 1.1 1.9 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.17 EDK38148.2 - 0.00012 21.8 2.1 0.77 10.0 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat IF-2B PF01008.12 EDK38149.2 - 1.7e-77 260.2 0.2 6.2e-77 258.3 0.1 1.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family FHIPEP PF00771.15 EDK38149.2 - 3.2 5.9 11.1 0.17 10.1 3.7 1.7 2 0 0 2 2 2 0 FHIPEP family SOBP PF15279.1 EDK38149.2 - 7 6.9 12.2 1.4 9.2 5.5 1.8 2 0 0 2 2 2 0 Sine oculis-binding protein HAD PF12710.2 EDK38150.2 - 1.4e-19 71.0 0.0 5e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EDK38150.2 - 1.5e-14 53.6 0.2 3e-14 52.6 0.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EDK38150.2 - 1.8e-13 51.4 1.5 8.8e-12 45.8 1.1 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK38150.2 - 2.5e-11 43.3 0.0 6.6e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EDK38150.2 - 0.002 17.7 0.2 0.016 14.7 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EDK38150.2 - 0.041 14.0 0.5 0.17 12.1 0.0 2.2 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Aldedh PF00171.17 EDK38151.2 - 1.1e-18 66.8 0.2 8.8e-15 53.9 0.1 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family GDI PF00996.13 EDK38152.2 - 6.2e-49 166.4 0.3 1.4e-48 165.3 0.0 1.6 2 0 0 2 2 2 1 GDP dissociation inhibitor FAD_binding_3 PF01494.14 EDK38152.2 - 0.0088 15.1 0.0 0.052 12.5 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Ribosomal_L7Ae PF01248.21 EDK38153.1 - 1.4e-25 88.5 0.6 1.9e-25 88.2 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family NTP_transf_3 PF12804.2 EDK38153.1 - 0.034 14.2 0.0 0.049 13.7 0.0 1.3 1 1 0 1 1 1 0 MobA-like NTP transferase domain DUF1269 PF06897.7 EDK38153.1 - 0.099 12.6 0.0 0.23 11.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1269) DUF2096 PF09869.4 EDK38153.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) APG6 PF04111.7 EDK38154.2 - 0.0005 19.2 3.1 0.00059 18.9 2.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 CorA PF01544.13 EDK38154.2 - 0.0005 19.1 1.4 0.00053 19.1 1.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein IncA PF04156.9 EDK38154.2 - 0.00076 19.1 1.4 0.00076 19.1 1.0 1.1 1 0 0 1 1 1 1 IncA protein Cortex-I_coil PF09304.5 EDK38154.2 - 0.0013 18.7 6.2 0.012 15.6 0.4 2.5 1 1 1 2 2 2 1 Cortexillin I, coiled coil EzrA PF06160.7 EDK38154.2 - 0.0021 16.3 3.7 0.0025 16.1 2.6 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Myosin_tail_1 PF01576.14 EDK38154.2 - 0.0047 14.7 3.7 0.005 14.6 2.6 1.1 1 0 0 1 1 1 1 Myosin tail DivIC PF04977.10 EDK38154.2 - 0.0065 15.9 1.0 0.0065 15.9 0.7 2.2 2 1 1 3 3 2 1 Septum formation initiator GAS PF13851.1 EDK38154.2 - 0.0081 15.3 6.0 0.01 15.0 4.2 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding MscS_porin PF12795.2 EDK38154.2 - 0.0095 15.2 1.6 0.011 15.0 0.7 1.5 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain Laminin_I PF06008.9 EDK38154.2 - 0.012 14.9 3.9 0.014 14.7 2.7 1.1 1 0 0 1 1 1 0 Laminin Domain I Laminin_II PF06009.7 EDK38154.2 - 0.013 15.3 3.2 0.13 12.0 0.4 2.3 1 1 1 2 2 2 0 Laminin Domain II Kinase-like PF14531.1 EDK38154.2 - 0.021 13.7 0.1 0.034 13.1 0.1 1.2 1 0 0 1 1 1 0 Kinase-like HD_3 PF13023.1 EDK38154.2 - 0.024 14.3 0.6 0.024 14.3 0.4 1.3 1 1 0 1 1 1 0 HD domain Mnd1 PF03962.10 EDK38154.2 - 0.024 14.2 0.8 0.029 14.0 0.6 1.2 1 0 0 1 1 1 0 Mnd1 family DUF4201 PF13870.1 EDK38154.2 - 0.03 13.7 6.5 0.015 14.7 3.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Halo_GVPC PF05465.8 EDK38154.2 - 0.031 14.1 0.1 0.27 11.2 0.2 2.2 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat Sipho_Gp157 PF05565.6 EDK38154.2 - 0.032 13.8 1.0 0.045 13.3 0.6 1.4 1 1 0 1 1 1 0 Siphovirus Gp157 DUF724 PF05266.9 EDK38154.2 - 0.043 13.4 1.4 0.059 12.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NPV_P10 PF05531.7 EDK38154.2 - 0.044 14.0 1.8 4.3 7.6 0.1 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.3 EDK38154.2 - 0.047 13.4 2.6 0.057 13.2 0.7 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.14 EDK38154.2 - 0.048 11.5 1.2 0.05 11.4 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.17 EDK38154.2 - 0.07 13.1 2.2 0.2 11.6 0.4 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Reo_sigmaC PF04582.7 EDK38154.2 - 0.08 12.1 0.3 0.15 11.2 0.2 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 EDK38154.2 - 0.087 12.5 4.7 0.12 12.1 3.2 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein TBPIP PF07106.8 EDK38154.2 - 0.093 12.2 3.6 0.16 11.5 1.7 1.8 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tnp_P_element PF12017.3 EDK38154.2 - 0.11 11.7 0.9 0.17 11.0 0.5 1.5 1 1 0 1 1 1 0 Transposase protein DUF1319 PF07028.6 EDK38154.2 - 0.11 12.6 5.3 0.27 11.4 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) DUF948 PF06103.6 EDK38154.2 - 0.11 12.3 1.7 4.6 7.1 0.1 2.2 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF972 PF06156.8 EDK38154.2 - 0.13 12.6 3.7 0.15 12.4 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) LMBR1 PF04791.11 EDK38154.2 - 0.15 10.6 0.7 0.16 10.5 0.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein HAUS6_N PF14661.1 EDK38154.2 - 0.15 11.4 1.8 0.19 11.0 1.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF1664 PF07889.7 EDK38154.2 - 0.18 11.6 1.9 0.56 10.0 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 EDK38154.2 - 0.35 9.7 4.7 0.45 9.4 3.3 1.3 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Prefoldin_2 PF01920.15 EDK38154.2 - 0.41 10.4 4.2 0.28 10.9 0.8 2.2 2 1 0 2 2 2 0 Prefoldin subunit Occludin_ELL PF07303.8 EDK38154.2 - 0.73 10.6 5.3 0.89 10.3 2.7 1.9 2 1 0 2 2 1 0 Occludin homology domain Snapin_Pallidin PF14712.1 EDK38154.2 - 0.9 9.8 4.4 2.8 8.2 0.3 2.7 1 1 2 3 3 3 0 Snapin/Pallidin Fib_alpha PF08702.5 EDK38154.2 - 4 7.5 5.7 6.4 6.8 3.2 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Cornichon PF03311.9 EDK38155.1 - 2.4e-50 169.9 7.2 2.7e-50 169.8 5.0 1.0 1 0 0 1 1 1 1 Cornichon protein LRR_4 PF12799.2 EDK38157.2 - 2e-21 75.1 27.2 4.8e-08 32.4 0.4 4.6 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK38157.2 - 4.3e-15 55.2 43.7 1.6e-06 27.7 3.7 4.4 1 1 4 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 EDK38157.2 - 5.1e-07 28.8 27.4 0.14 12.3 0.5 7.9 6 1 1 7 7 7 5 Leucine Rich Repeat LRR_7 PF13504.1 EDK38157.2 - 6.6e-06 25.4 12.5 9.5 6.9 0.0 6.7 6 0 0 6 6 6 3 Leucine rich repeat LRR_9 PF14580.1 EDK38157.2 - 7e-05 22.4 9.2 0.076 12.5 0.1 3.2 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.1 EDK38157.2 - 0.0036 17.2 27.0 1 9.6 0.2 7.3 6 1 1 7 7 7 2 Leucine Rich repeat RRM_1 PF00076.17 EDK38159.2 - 2.8e-47 158.2 0.1 9.6e-19 66.8 0.0 4.1 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38159.2 - 8.1e-32 109.0 0.0 2.1e-11 43.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38159.2 - 1e-25 89.3 0.0 6.1e-12 45.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK38159.2 - 6.5e-06 25.8 0.0 0.00019 21.1 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EDK38159.2 - 0.003 17.3 0.0 0.003 17.3 0.0 2.8 4 0 0 4 4 4 1 RNA binding motif Nup35_RRM PF05172.8 EDK38159.2 - 0.085 12.6 0.0 6.8 6.5 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Histone PF00125.19 EDK38160.1 - 1.6e-32 111.4 0.6 2.8e-32 110.6 0.4 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EDK38160.1 - 1.8e-06 28.0 0.0 2.7e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EDK38160.1 - 0.00077 19.4 0.1 0.0017 18.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EDK38160.1 - 0.038 13.7 0.1 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated CENP-T PF15511.1 EDK38160.1 - 0.045 13.0 1.0 0.14 11.4 0.1 1.8 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T Oxidored_q6 PF01058.17 EDK38161.1 - 1.8e-21 76.1 0.1 2.6e-21 75.6 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit EnY2 PF10163.4 EDK38162.2 - 1e-36 124.7 0.7 1.1e-36 124.5 0.5 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF2738 PF10927.3 EDK38162.2 - 0.024 13.6 0.5 0.8 8.7 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2738) NUDIX PF00293.23 EDK38163.2 - 6.7e-15 54.9 0.0 1e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain FANCL_C PF11793.3 EDK38164.2 - 0.0011 18.9 1.9 0.07 13.1 0.2 2.6 2 0 0 2 2 2 2 FANCL C-terminal domain RINGv PF12906.2 EDK38164.2 - 0.047 13.7 2.5 0.049 13.6 0.6 1.9 2 0 0 2 2 2 0 RING-variant domain NPCC PF08058.6 EDK38164.2 - 0.091 12.6 0.1 0.29 10.9 0.1 1.8 1 0 0 1 1 1 0 Nuclear pore complex component zf-RING_2 PF13639.1 EDK38164.2 - 1.8 8.4 5.0 0.56 10.0 0.9 2.0 2 0 0 2 2 2 0 Ring finger domain TPR_1 PF00515.23 EDK38165.2 - 1.6e-54 179.3 28.9 8.7e-08 31.4 0.0 11.5 11 2 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38165.2 - 1.3e-52 171.4 25.7 3.3e-06 26.6 0.0 10.4 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_11 PF13414.1 EDK38165.2 - 2e-50 168.2 22.1 4.2e-11 42.3 0.2 6.5 2 2 4 7 7 7 7 TPR repeat TPR_8 PF13181.1 EDK38165.2 - 7.9e-38 125.4 15.7 0.00032 20.2 0.0 10.3 9 1 2 11 11 11 8 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38165.2 - 1.4e-37 127.5 17.9 6.4e-07 29.8 0.0 6.7 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38165.2 - 2.3e-35 120.3 22.1 8.6e-08 32.0 0.2 7.1 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_17 PF13431.1 EDK38165.2 - 1.8e-34 115.0 19.0 0.00065 19.6 0.1 10.5 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_19 PF14559.1 EDK38165.2 - 1.2e-31 108.7 15.5 4.3e-06 26.9 0.3 6.7 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 EDK38165.2 - 2.2e-31 105.4 14.6 4e-06 26.9 0.1 9.7 4 2 6 10 10 10 7 Tetratricopeptide repeat TPR_7 PF13176.1 EDK38165.2 - 3.1e-25 85.9 17.8 0.0036 16.9 0.0 9.4 10 1 0 10 10 9 6 Tetratricopeptide repeat TPR_6 PF13174.1 EDK38165.2 - 5.5e-23 79.8 15.5 0.0011 19.2 0.0 9.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_9 PF13371.1 EDK38165.2 - 1.6e-21 75.9 8.2 1.6e-05 24.6 0.0 6.0 2 2 6 8 8 8 8 Tetratricopeptide repeat Apc3 PF12895.2 EDK38165.2 - 6e-17 61.5 7.4 4.1e-07 30.0 0.3 4.0 4 1 1 5 5 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 EDK38165.2 - 5.3e-12 45.3 8.0 0.00052 19.1 0.3 5.4 3 3 2 5 5 5 3 Tetratricopeptide repeat NARP1 PF12569.3 EDK38165.2 - 1.3e-06 27.4 0.1 1 8.0 0.0 4.3 4 1 1 5 5 5 2 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.1 EDK38165.2 - 0.00033 20.4 4.0 0.058 13.2 0.0 5.0 5 0 0 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.4 EDK38165.2 - 0.00035 20.5 3.3 4.3 7.2 0.4 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.1 EDK38165.2 - 0.00062 19.0 6.0 3.4 6.7 0.2 4.9 1 1 3 4 4 4 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.1 EDK38165.2 - 0.00065 19.5 23.7 0.097 12.6 0.2 7.7 9 0 0 9 9 8 1 Tetratricopeptide repeat MIT PF04212.13 EDK38165.2 - 0.0024 17.7 15.7 0.68 9.8 0.0 6.4 5 2 1 6 6 6 2 MIT (microtubule interacting and transport) domain ChAPs PF09295.5 EDK38165.2 - 0.0029 16.4 0.1 0.14 10.9 0.0 2.8 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.1 EDK38165.2 - 0.0055 16.7 0.1 2.7 8.1 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat YfiO PF13525.1 EDK38165.2 - 0.0057 16.1 1.2 3.3 7.1 0.0 3.1 2 1 0 2 2 2 1 Outer membrane lipoprotein TOM20_plant PF06552.7 EDK38165.2 - 0.0099 15.4 0.4 11 5.5 0.0 3.7 2 1 2 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 Rapsyn_N PF10579.4 EDK38165.2 - 0.06 13.1 0.1 10 6.0 0.0 3.4 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region TPR_3 PF07720.7 EDK38165.2 - 2.3 8.1 20.4 18 5.2 0.2 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat NAD_kinase PF01513.16 EDK38166.2 - 1.5e-51 174.8 0.0 2e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 EDK38166.2 - 0.0063 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Glyco_tran_28_C PF04101.11 EDK38166.2 - 0.022 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Hist_deacetyl PF00850.14 EDK38167.2 - 7.5e-78 261.9 0.0 1e-77 261.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain zf-DHHC PF01529.15 EDK38168.2 - 1.7e-38 131.7 8.1 1.7e-38 131.7 5.6 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase UAA PF08449.6 EDK38169.2 - 7.2e-66 222.1 16.9 9.1e-66 221.8 11.7 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 EDK38169.2 - 1.7e-06 27.7 22.2 8.6e-05 22.2 6.6 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 EDK38169.2 - 7.8e-06 25.9 26.2 0.00014 21.8 6.1 3.0 3 0 0 3 3 3 2 EamA-like transporter family Phage_Treg PF04761.7 EDK38169.2 - 0.038 13.7 0.4 0.71 9.6 0.0 2.8 3 0 0 3 3 3 0 Lactococcus bacteriophage putative transcription regulator EmrE PF13536.1 EDK38169.2 - 2.5 8.3 23.1 3.2 7.9 2.8 3.6 3 2 0 3 3 3 0 Multidrug resistance efflux transporter PALP PF00291.20 EDK38172.2 - 4.1e-71 239.7 0.0 6.2e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 EDK38172.2 - 1.5e-46 155.9 0.1 5.9e-29 99.5 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase GTP_EFTU PF00009.22 EDK38173.2 - 3.9e-48 163.3 0.0 8.8e-48 162.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 EDK38173.2 - 7.6e-36 122.2 8.2 7.9e-35 119.0 4.5 2.3 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 EDK38173.2 - 1.1e-20 73.2 0.0 2.4e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EDK38173.2 - 8.7e-06 25.7 0.4 2.2e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Ras PF00071.17 EDK38173.2 - 0.00016 21.0 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 EDK38173.2 - 0.00024 21.0 0.0 0.00049 20.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.1 EDK38173.2 - 0.0085 15.9 0.0 0.026 14.3 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.5 EDK38173.2 - 0.011 14.9 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Aminotran_5 PF00266.14 EDK38174.1 - 6.8e-26 90.8 0.0 7.4e-26 90.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Mesothelin PF06060.7 EDK38174.1 - 0.08 10.9 0.0 0.11 10.5 0.0 1.2 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Hus1 PF04005.7 EDK38175.2 - 2.1e-58 197.6 0.4 2.5e-58 197.3 0.3 1.0 1 0 0 1 1 1 1 Hus1-like protein LSM PF01423.17 EDK38176.1 - 7.4e-17 60.6 1.1 9.9e-17 60.2 0.8 1.1 1 0 0 1 1 1 1 LSM domain CPSF73-100_C PF11718.3 EDK38177.2 - 4.2e-74 248.5 0.0 6.7e-74 247.8 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 EDK38177.2 - 5.6e-34 116.7 0.1 2.8e-33 114.5 0.0 2.3 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B PF00753.22 EDK38177.2 - 3e-17 62.9 0.7 5.6e-17 62.0 0.5 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EDK38177.2 - 4.9e-13 49.0 1.1 8.4e-13 48.3 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 EDK38177.2 - 1.2e-09 37.8 0.0 2.5e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 EDK38177.2 - 4.2e-07 29.8 0.0 1.1e-06 28.4 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain MCM PF00493.18 EDK38178.1 - 2.6e-142 473.5 0.1 3.5e-142 473.0 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EDK38178.1 - 3.3e-21 76.0 0.5 9.7e-21 74.4 0.3 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 EDK38178.1 - 1.8e-06 27.2 0.0 0.00069 18.8 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EDK38178.1 - 1.7e-05 24.5 0.0 4.7e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EDK38178.1 - 0.00027 20.5 0.2 0.0032 17.0 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_2 PF13335.1 EDK38178.1 - 0.018 15.4 0.3 0.085 13.2 0.2 2.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 EDK38178.1 - 0.027 13.9 0.0 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain RF-1 PF00472.15 EDK38179.2 - 5.6e-23 80.9 4.1 7e-23 80.6 2.6 1.3 1 1 0 1 1 1 1 RF-1 domain MIR PF02815.14 EDK38179.2 - 0.026 14.0 0.2 0.16 11.4 0.0 2.1 1 1 0 2 2 2 0 MIR domain UPF0172 PF03665.8 EDK38179.2 - 0.029 13.8 0.7 0.036 13.5 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) ADIP PF11559.3 EDK38180.2 - 3.1e-48 163.5 16.5 3.1e-48 163.5 11.4 2.0 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.3 EDK38180.2 - 0.0034 17.1 5.8 0.0034 17.1 4.0 3.4 4 0 0 4 4 4 1 TATA element modulatory factor 1 DNA binding Spc7 PF08317.6 EDK38180.2 - 0.0091 14.6 17.8 0.015 14.0 7.8 2.6 2 1 0 2 2 2 1 Spc7 kinetochore protein Reo_sigmaC PF04582.7 EDK38180.2 - 0.022 13.9 9.4 0.019 14.1 1.4 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Glutaredoxin2_C PF04399.8 EDK38180.2 - 0.031 13.8 2.6 0.1 12.2 1.8 1.9 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF1947 PF09183.5 EDK38180.2 - 0.07 12.8 0.4 0.32 10.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) TMF_TATA_bd PF12325.3 EDK38180.2 - 0.09 12.5 14.4 0.98 9.1 3.3 3.7 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding FliJ PF02050.11 EDK38180.2 - 0.13 12.3 14.3 5.5 7.0 0.1 3.4 3 0 0 3 3 3 0 Flagellar FliJ protein DUF1664 PF07889.7 EDK38180.2 - 0.21 11.3 10.0 0.047 13.4 2.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 EDK38180.2 - 0.6 9.0 15.0 3 6.7 10.4 2.1 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4407 PF14362.1 EDK38180.2 - 0.68 8.8 5.0 1.2 8.0 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ACCA PF03255.9 EDK38180.2 - 2.2 7.7 6.8 2.8 7.4 1.6 2.8 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit HWE_HK PF07536.9 EDK38180.2 - 2.6 8.5 5.5 3.5 8.1 2.1 2.5 2 1 0 2 2 2 0 HWE histidine kinase Tropomyosin_1 PF12718.2 EDK38180.2 - 2.7 7.8 18.3 2.6 7.8 8.2 3.1 2 1 0 2 2 2 0 Tropomyosin like Uds1 PF15456.1 EDK38180.2 - 6.7 6.7 10.0 8 6.4 1.2 3.3 2 1 0 3 3 3 0 Up-regulated During Septation DUF848 PF05852.6 EDK38180.2 - 8 6.3 14.9 3.7 7.3 5.0 3.4 3 1 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) IncA PF04156.9 EDK38180.2 - 9.3 5.7 16.9 0.49 9.9 4.9 2.9 3 1 0 3 3 3 0 IncA protein Ras PF00071.17 EDK38181.1 - 2.5e-49 166.7 0.0 3.1e-49 166.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK38181.1 - 6.4e-15 55.7 0.0 1.3e-14 54.6 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EDK38181.1 - 1.7e-10 40.4 0.0 2.1e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 EDK38181.1 - 0.00043 20.4 0.1 0.0018 18.4 0.0 1.9 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 EDK38181.1 - 0.0016 17.6 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pox_A32 PF04665.7 EDK38181.1 - 0.028 13.7 0.1 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_22 PF13401.1 EDK38181.1 - 0.057 13.5 0.2 0.19 11.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 EDK38181.1 - 0.064 11.9 2.5 1.2 7.8 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit AAA_33 PF13671.1 EDK38181.1 - 0.087 12.7 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain RRM_6 PF14259.1 EDK38182.2 - 2.7e-14 52.8 1.5 4.8e-08 32.8 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK38182.2 - 4.4e-12 45.4 3.5 0.0018 17.8 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38182.2 - 8.3e-08 31.9 2.2 0.029 14.2 0.0 3.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aa_trans PF01490.13 EDK38183.2 - 5.6e-53 179.8 32.2 6.7e-53 179.6 22.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 EDK38183.2 - 0.00015 20.7 10.4 0.00015 20.7 7.2 2.2 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family KilA-N PF04383.8 EDK38184.2 - 4.3e-05 23.1 0.0 0.0021 17.6 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain Glyoxalase PF00903.20 EDK38185.2 - 2.8e-08 33.7 0.0 4.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 EDK38185.2 - 8.7e-05 22.4 0.0 0.00023 21.1 0.0 1.7 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TauD PF02668.11 EDK38186.2 - 0.04 13.5 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family MHC_II_alpha PF00993.15 EDK38186.2 - 0.085 12.4 0.6 0.33 10.5 0.1 2.1 2 0 0 2 2 2 0 Class II histocompatibility antigen, alpha domain RTA1 PF04479.8 EDK38187.2 - 7.3e-54 182.6 2.8 1.3e-53 181.8 1.9 1.3 1 1 0 1 1 1 1 RTA1 like protein Pex24p PF06398.6 EDK38187.2 - 0.075 11.8 1.8 0.11 11.2 0.0 2.1 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin DUF202 PF02656.10 EDK38187.2 - 5.6 7.2 6.6 5.8 7.1 1.7 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF202) RTA1 PF04479.8 EDK38188.1 - 6.7e-17 61.7 2.5 7.9e-17 61.5 1.7 1.1 1 0 0 1 1 1 1 RTA1 like protein Endonuc_BglI PF14562.1 EDK38188.1 - 0.14 10.9 0.2 0.24 10.2 0.0 1.5 2 0 0 2 2 2 0 Restriction endonuclease BglI RTA1 PF04479.8 EDK38189.2 - 2.7e-33 115.3 9.9 3.3e-33 115.0 6.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Wzy_C PF04932.10 EDK38189.2 - 0.37 10.5 4.8 0.63 9.8 0.2 2.3 1 1 1 2 2 2 0 O-Antigen ligase DUF2530 PF10745.4 EDK38189.2 - 5 7.1 5.3 20 5.2 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) RTA1 PF04479.8 EDK38190.1 - 3.8e-41 141.0 7.5 7.2e-41 140.1 5.2 1.4 1 1 0 1 1 1 1 RTA1 like protein Bac_export_1 PF01311.15 EDK38190.1 - 0.03 13.6 0.2 0.03 13.6 0.2 1.7 2 0 0 2 2 2 0 Bacterial export proteins, family 1 PgaD PF13994.1 EDK38190.1 - 0.045 13.2 0.1 0.62 9.5 0.0 2.2 2 0 0 2 2 2 0 PgaD-like protein zf-DHHC PF01529.15 EDK38190.1 - 4.4 6.6 7.0 1.2 8.5 0.2 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase RTA1 PF04479.8 EDK38191.2 - 0.011 15.2 0.0 0.011 15.2 0.0 1.7 2 0 0 2 2 2 0 RTA1 like protein zf-Di19 PF05605.7 EDK38191.2 - 0.062 13.4 0.1 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PhnA_Zn_Ribbon PF08274.7 EDK38191.2 - 0.098 12.4 1.2 0.24 11.1 0.8 1.7 1 1 0 1 1 1 0 PhnA Zinc-Ribbon UPF0547 PF10571.4 EDK38191.2 - 0.25 11.0 0.1 0.25 11.0 0.1 1.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Aldo_ket_red PF00248.16 EDK38192.1 - 2.9e-53 180.5 0.0 3.4e-53 180.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2380 PF09533.5 EDK38192.1 - 0.046 13.1 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Ribosomal_L28e PF01778.12 EDK38193.2 - 7.5e-32 110.1 3.2 7.5e-32 110.1 2.2 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.9 EDK38193.2 - 1.9e-30 104.9 16.0 1.9e-30 104.9 11.1 2.3 2 1 0 2 2 2 1 Mak16 protein C-terminal region TFIIF_alpha PF05793.7 EDK38193.2 - 0.72 8.1 22.0 0.84 7.9 15.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Glyco_hydro_3_C PF01915.17 EDK38194.2 - 1.6e-37 129.1 1.1 2.4e-36 125.4 0.8 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EDK38194.2 - 1.1e-21 76.5 0.0 1.9e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.6 EDK38194.2 - 0.0062 16.5 0.1 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 CARDB Phage_tail_X PF05489.7 EDK38194.2 - 0.12 11.8 0.5 0.37 10.2 0.0 1.9 2 0 0 2 2 2 0 Phage Tail Protein X Glyco_hydro_3 PF00933.16 EDK38195.1 - 8e-80 267.9 0.0 1.1e-79 267.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EDK38195.1 - 8.5e-18 64.7 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PA14 PF07691.7 EDK38195.1 - 7.1e-14 51.6 0.3 1.3e-13 50.7 0.2 1.4 1 0 0 1 1 1 1 PA14 domain Fungal_trans PF04082.13 EDK38196.2 - 1.2e-11 43.9 0.4 1.2e-11 43.9 0.3 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38196.2 - 4.9e-07 29.5 8.3 1.1e-06 28.4 5.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 EDK38197.2 - 1.3e-10 40.4 0.1 1.5e-10 40.3 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Hid1 PF12722.2 EDK38198.2 - 0.011 13.4 0.1 0.012 13.2 0.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Lipase3_N PF03893.11 EDK38198.2 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Lipase 3 N-terminal region DUF4230 PF14014.1 EDK38199.2 - 0.23 11.2 7.6 0.038 13.8 2.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4230) Nebulin PF00880.13 EDK38199.2 - 0.41 10.3 0.1 0.41 10.3 0.0 3.1 3 0 0 3 3 3 0 Nebulin repeat TRI12 PF06609.8 EDK38200.2 - 4.5e-05 21.8 20.9 6.2e-05 21.3 14.5 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EDK38200.2 - 0.0036 15.9 18.8 0.0036 15.9 13.0 3.1 2 2 0 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK38200.2 - 0.012 14.3 44.6 0.22 10.2 30.9 2.6 1 1 0 1 1 1 0 Major Facilitator Superfamily Pox_A14 PF05767.7 EDK38200.2 - 0.015 15.2 0.4 0.015 15.2 0.3 3.8 3 1 2 5 5 5 0 Poxvirus virion envelope protein A14 DUF3852 PF12963.2 EDK38200.2 - 0.04 13.9 2.8 0.13 12.3 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3852) Candida_ALS PF05792.8 EDK38202.2 - 1.4e-104 341.8 291.5 4.4e-10 39.5 11.8 15.2 14 0 0 14 14 14 12 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.3 EDK38204.2 - 7.6e-85 283.7 6.8 7.6e-85 283.7 4.7 1.8 2 0 0 2 2 2 1 Cell-wall agglutinin N-terminal ligand-sugar binding Candida_ALS PF05792.8 EDK38204.2 - 6.1e-78 256.5 260.4 8.6e-11 41.7 14.3 11.0 11 0 0 11 11 11 9 Candida agglutinin-like (ALS) ABC_membrane PF00664.18 EDK38205.2 - 3.2e-50 171.0 47.2 7.6e-31 107.5 16.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK38205.2 - 5.2e-48 162.8 0.8 1.4e-29 103.1 0.1 3.4 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 EDK38205.2 - 7.2e-07 29.4 3.2 0.0035 17.3 0.9 4.4 3 1 0 3 3 3 1 AAA domain AAA_29 PF13555.1 EDK38205.2 - 1.4e-06 27.6 0.9 0.0048 16.3 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 EDK38205.2 - 8.2e-06 26.6 0.0 0.09 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 EDK38205.2 - 2.7e-05 23.4 0.3 0.05 12.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 EDK38205.2 - 3.1e-05 23.9 1.1 0.026 14.5 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SE PF00437.15 EDK38205.2 - 5.7e-05 22.1 0.0 0.051 12.4 0.0 2.9 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_16 PF13191.1 EDK38205.2 - 0.00011 22.1 1.1 0.0081 16.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 EDK38205.2 - 0.00013 21.2 10.5 1.9 7.6 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 EDK38205.2 - 0.00024 21.4 10.6 0.033 14.5 2.8 3.2 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EDK38205.2 - 0.0003 21.1 0.7 0.51 10.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain cobW PF02492.14 EDK38205.2 - 0.00039 19.9 0.5 0.052 12.9 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 EDK38205.2 - 0.0026 17.2 1.2 0.42 9.9 0.0 3.0 3 0 0 3 3 3 1 AAA-like domain FtsK_SpoIIIE PF01580.13 EDK38205.2 - 0.0034 16.8 0.1 0.78 9.1 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 EDK38205.2 - 0.0047 17.0 5.3 4.3 7.4 0.1 3.7 2 1 0 2 2 2 1 AAA domain Miro PF08477.8 EDK38205.2 - 0.0056 17.1 2.4 1.4 9.4 0.1 3.1 3 0 0 3 3 2 1 Miro-like protein Zeta_toxin PF06414.7 EDK38205.2 - 0.008 15.2 0.4 1.2 8.1 0.1 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_14 PF13173.1 EDK38205.2 - 0.0095 15.8 2.1 2.3 8.1 0.0 3.5 2 1 1 3 3 3 1 AAA domain AAA_19 PF13245.1 EDK38205.2 - 0.01 15.5 0.1 0.032 13.9 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain Dynamin_N PF00350.18 EDK38205.2 - 0.016 15.0 5.7 1.5 8.6 0.1 3.0 3 0 0 3 3 3 0 Dynamin family AAA_30 PF13604.1 EDK38205.2 - 0.02 14.4 1.5 1.3 8.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 EDK38205.2 - 0.04 13.4 0.0 1.7 8.0 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain UPF0079 PF02367.12 EDK38205.2 - 0.042 13.4 0.3 0.27 10.8 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA PF00004.24 EDK38205.2 - 0.091 12.9 1.9 0.84 9.8 0.1 3.4 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.13 EDK38205.2 - 0.24 10.9 2.5 1.7 8.1 0.1 2.9 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family Arch_ATPase PF01637.13 EDK38205.2 - 0.49 10.0 0.0 0.49 10.0 0.0 3.8 3 1 0 3 3 3 0 Archaeal ATPase Pkinase PF00069.20 EDK38206.2 - 3.9e-62 209.7 0.0 7.1e-62 208.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38206.2 - 6.2e-38 130.3 0.0 5.7e-37 127.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38206.2 - 0.0063 15.5 0.0 0.013 14.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK38206.2 - 0.009 15.7 0.0 0.79 9.4 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family IncA PF04156.9 EDK38206.2 - 0.018 14.6 7.8 0.044 13.3 5.4 1.7 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.4 EDK38206.2 - 4.7 6.0 10.8 5.6 5.8 6.9 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 SAICAR_synt PF01259.13 EDK38207.2 - 4.2e-101 337.2 0.1 5e-101 336.9 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase MutS_V PF00488.16 EDK38208.2 - 8.7e-93 310.0 0.0 1.4e-92 309.4 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EDK38208.2 - 4.3e-29 101.7 1.0 8.1e-29 100.8 0.7 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 EDK38208.2 - 1.4e-14 54.0 2.2 5.3e-14 52.1 1.5 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 EDK38208.2 - 5.4e-13 49.1 0.8 1.2e-12 48.0 0.0 2.0 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.15 EDK38208.2 - 0.00072 19.5 0.2 0.0049 16.8 0.1 2.3 2 0 0 2 2 2 1 MutS domain I Ceramidase PF05875.7 EDK38209.2 - 4.8e-104 347.1 11.1 5.6e-104 346.9 7.7 1.0 1 0 0 1 1 1 1 Ceramidase DUF4131 PF13567.1 EDK38209.2 - 0.35 10.2 7.7 2 7.7 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) p450 PF00067.17 EDK38210.2 - 4.4e-42 144.1 1.2 6.2e-39 133.8 0.0 2.3 1 1 0 2 2 2 2 Cytochrome P450 Cellulose_synt PF03552.9 EDK38210.2 - 0.02 13.2 0.0 0.028 12.7 0.0 1.2 1 0 0 1 1 1 0 Cellulose synthase FliD_N PF02465.13 EDK38210.2 - 0.074 13.4 3.3 0.14 12.5 0.6 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus PAPS_reduct PF01507.14 EDK38211.2 - 2.1e-42 144.9 0.0 2.9e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DNA_binding_1 PF01035.15 EDK38212.2 - 2.6e-25 87.9 0.1 4.4e-25 87.2 0.1 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Glyco_hydro_32N PF00251.15 EDK38212.2 - 0.078 12.3 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain DMPK_coil PF08826.5 EDK38213.2 - 8.2 6.4 7.0 3.4 7.6 0.2 2.7 2 1 1 3 3 3 0 DMPK coiled coil domain like PH PF00169.24 EDK38214.2 - 1.4e-09 38.0 1.1 1.4e-09 38.0 0.7 2.8 3 0 0 3 3 3 1 PH domain Prefoldin_2 PF01920.15 EDK38214.2 - 0.0024 17.5 1.7 0.36 10.6 0.0 3.2 2 0 0 2 2 2 2 Prefoldin subunit PH_11 PF15413.1 EDK38214.2 - 3 8.1 10.3 0.09 13.0 0.5 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain CDP-OH_P_transf PF01066.16 EDK38215.1 - 9.4e-12 45.1 3.9 1.7e-11 44.2 2.7 1.4 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase NIF PF03031.13 EDK38217.2 - 3.4e-43 147.0 0.1 6.8e-43 146.0 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SYF2 PF08231.7 EDK38217.2 - 0.056 13.5 0.8 0.056 13.5 0.6 3.0 3 0 0 3 3 3 0 SYF2 splicing factor NDUF_B6 PF09782.4 EDK38217.2 - 0.066 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Hap4_Hap_bind PF10297.4 EDK38218.2 - 1.9e-09 37.0 7.4 5.9e-09 35.4 5.1 1.9 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.16 EDK38218.2 - 1.3e-06 28.2 17.3 6.1e-06 26.0 7.7 2.5 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.10 EDK38218.2 - 0.02 14.6 19.5 0.35 10.7 8.0 2.7 1 1 1 2 2 2 0 Basic region leucine zipper PP2C_C PF07830.8 EDK38218.2 - 2.3 8.4 4.6 0.62 10.2 0.1 2.3 3 0 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain Pet127 PF08634.5 EDK38219.2 - 3.2e-103 344.6 0.0 4.9e-103 344.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 6PF2K PF01591.13 EDK38220.1 - 4e-48 163.4 1.3 6e-48 162.8 0.9 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 EDK38220.1 - 3.8e-11 43.0 0.0 6.2e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 EDK38220.1 - 2.9e-07 29.9 0.0 4.3e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 APS_kinase PF01583.15 EDK38220.1 - 3.2e-07 30.1 0.0 5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.1 EDK38220.1 - 3e-06 28.0 0.0 6.5e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK38220.1 - 2e-05 24.8 0.0 4.7e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 EDK38220.1 - 9.4e-05 21.9 0.1 0.00019 20.9 0.0 1.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 EDK38220.1 - 0.0003 19.9 0.0 0.00059 19.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin MobB PF03205.9 EDK38220.1 - 0.00087 19.0 0.0 0.0033 17.1 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B G-alpha PF00503.15 EDK38220.1 - 0.0025 16.5 0.0 0.0025 16.5 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit AAA_16 PF13191.1 EDK38220.1 - 0.0047 16.9 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EDK38220.1 - 0.0076 16.4 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EDK38220.1 - 0.0096 15.3 0.0 0.014 14.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EDK38220.1 - 0.012 15.5 0.0 0.34 10.7 0.0 2.7 2 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.10 EDK38220.1 - 0.019 14.6 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.12 EDK38220.1 - 0.022 14.3 0.0 0.046 13.2 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein ArgK PF03308.11 EDK38220.1 - 0.022 13.5 0.0 0.046 12.4 0.0 1.5 2 0 0 2 2 2 0 ArgK protein NB-ARC PF00931.17 EDK38220.1 - 0.031 13.1 0.0 0.057 12.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.9 EDK38220.1 - 0.035 13.8 0.0 0.065 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 EDK38220.1 - 0.035 14.0 0.0 0.08 12.9 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 EDK38220.1 - 0.048 13.9 0.0 0.081 13.2 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.1 EDK38220.1 - 0.087 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 EDK38220.1 - 0.093 12.3 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA PF00004.24 EDK38220.1 - 0.11 12.6 0.3 0.8 9.9 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) WD40 PF00400.27 EDK38221.2 - 5.1e-44 146.6 14.8 3.4e-09 36.2 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 EDK38221.2 - 5.9e-07 29.3 1.2 0.019 14.6 0.1 3.7 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A ARD PF03079.9 EDK38222.2 - 5.5e-39 133.6 0.3 6.6e-39 133.3 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 EDK38222.2 - 1.1e-09 37.6 0.0 1.7e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 EDK38222.2 - 3.1e-07 30.1 0.0 4.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 EDK38222.2 - 9e-05 21.9 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.7 EDK38222.2 - 0.019 14.3 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Prefoldin_2 PF01920.15 EDK38223.2 - 6.3e-16 58.0 5.1 6.3e-16 58.0 3.6 1.3 2 0 0 2 2 1 1 Prefoldin subunit Prefoldin PF02996.12 EDK38223.2 - 2.3e-06 27.2 4.3 6.6e-06 25.7 3.0 1.7 1 1 0 1 1 1 1 Prefoldin subunit DUF904 PF06005.7 EDK38223.2 - 0.0031 17.7 11.4 0.02 15.1 1.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF904) DUF1640 PF07798.6 EDK38223.2 - 0.0066 16.5 8.5 0.11 12.5 1.7 2.0 1 1 0 2 2 2 2 Protein of unknown function (DUF1640) COG2 PF06148.6 EDK38223.2 - 0.013 15.3 4.0 1.1 9.1 0.3 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4200 PF13863.1 EDK38223.2 - 0.035 14.0 10.8 0.22 11.4 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Seryl_tRNA_N PF02403.17 EDK38223.2 - 0.042 13.8 7.2 1.7 8.7 0.1 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain phiKZ_IP PF12699.2 EDK38223.2 - 0.068 12.0 2.0 0.17 10.8 0.2 1.9 1 1 1 2 2 2 0 phiKZ-like phage internal head proteins DivIC PF04977.10 EDK38223.2 - 0.074 12.5 7.6 0.081 12.4 0.1 2.5 2 1 0 2 2 2 0 Septum formation initiator Imm16 PF15565.1 EDK38223.2 - 0.097 12.5 0.4 0.18 11.7 0.2 1.5 1 1 0 1 1 1 0 Immunity protein 16 AAA_27 PF13514.1 EDK38223.2 - 0.1 10.2 6.8 0.23 9.1 4.7 1.5 1 1 0 1 1 1 0 AAA domain DUF3142 PF11340.3 EDK38223.2 - 0.11 12.1 2.1 0.66 9.6 1.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3142) Thioredoxin_6 PF13848.1 EDK38223.2 - 0.11 12.3 0.8 11 5.8 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Filament PF00038.16 EDK38223.2 - 0.15 11.4 7.9 0.6 9.5 0.5 2.0 2 0 0 2 2 2 0 Intermediate filament protein Cast PF10174.4 EDK38223.2 - 0.19 9.7 10.3 0.27 9.2 0.4 2.0 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone FliD_N PF02465.13 EDK38223.2 - 0.21 11.9 6.9 0.28 11.5 1.5 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Rootletin PF15035.1 EDK38223.2 - 0.24 11.3 11.2 0.97 9.3 7.8 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Laminin_II PF06009.7 EDK38223.2 - 0.33 10.7 7.5 0.84 9.3 0.5 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF1319 PF07028.6 EDK38223.2 - 0.33 11.1 4.1 0.35 11.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) RmuC PF02646.11 EDK38223.2 - 0.4 9.4 6.6 1.2 7.9 0.6 2.0 2 0 0 2 2 2 0 RmuC family DivIVA PF05103.8 EDK38223.2 - 0.41 10.7 9.3 0.24 11.4 0.5 2.3 2 1 0 2 2 2 0 DivIVA protein DUF3010 PF11215.3 EDK38223.2 - 0.46 10.4 4.7 1.9 8.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3010) SMC_Nse1 PF07574.8 EDK38223.2 - 0.52 9.8 5.1 2.2 7.8 0.1 2.1 2 0 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex L31 PF09784.4 EDK38223.2 - 0.55 10.3 4.6 0.14 12.2 0.7 1.8 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 APG6 PF04111.7 EDK38223.2 - 0.57 9.1 8.3 0.47 9.4 4.5 1.6 1 1 0 1 1 1 0 Autophagy protein Apg6 HAP1_N PF04849.8 EDK38223.2 - 0.6 9.0 7.1 3.1 6.6 0.6 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF1664 PF07889.7 EDK38223.2 - 0.69 9.7 5.0 4.9 6.9 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 EDK38223.2 - 0.7 10.0 9.7 2.1 8.4 0.7 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family CDC37_N PF03234.9 EDK38223.2 - 0.74 10.1 8.6 2.1 8.6 5.9 1.6 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding TPR_MLP1_2 PF07926.7 EDK38223.2 - 0.89 9.2 11.5 2.7 7.7 0.6 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.14 EDK38223.2 - 0.9 9.0 7.7 3.8 7.0 0.3 2.1 2 0 0 2 2 2 0 GrpE DUF3138 PF11336.3 EDK38223.2 - 1 7.4 3.7 1.1 7.3 2.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) BLOC1_2 PF10046.4 EDK38223.2 - 1.3 9.1 9.4 3 8.0 0.4 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med4 PF10018.4 EDK38223.2 - 1.3 8.3 7.0 0.87 8.9 0.8 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF972 PF06156.8 EDK38223.2 - 1.5 9.2 5.8 2.5 8.5 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF4446 PF14584.1 EDK38223.2 - 1.6 8.5 8.2 1.2 9.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) LOH1CR12 PF10158.4 EDK38223.2 - 1.9 8.2 5.8 13 5.6 0.4 2.1 2 0 0 2 2 2 0 Tumour suppressor protein DUF342 PF03961.8 EDK38223.2 - 2.1 6.6 9.3 1.8 6.8 0.8 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF342) ThylakoidFormat PF11264.3 EDK38223.2 - 2.3 7.7 7.1 1.9 8.0 0.6 2.0 1 1 1 2 2 2 0 Thylakoid formation protein IncA PF04156.9 EDK38223.2 - 2.3 7.7 13.8 36 3.8 9.6 2.0 1 1 0 1 1 1 0 IncA protein WXG100 PF06013.7 EDK38223.2 - 2.4 8.2 8.6 16 5.5 0.1 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TMF_DNA_bd PF12329.3 EDK38223.2 - 2.4 8.0 8.8 6.8 6.5 1.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Vfa1 PF08432.5 EDK38223.2 - 2.6 8.0 6.5 5.1 7.0 0.5 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 M_domain PF12938.2 EDK38223.2 - 3.9 7.2 9.3 1.5 8.6 3.4 1.9 1 1 0 2 2 2 0 M domain of GW182 DUF4140 PF13600.1 EDK38223.2 - 4.3 7.8 6.2 15 6.0 0.2 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Ring_hydroxyl_A PF00848.14 EDK38224.2 - 0.083 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) DDOST_48kD PF03345.9 EDK38225.2 - 4.6e-111 371.3 7.0 1.8e-109 366.1 4.9 2.0 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta PDZ_2 PF13180.1 EDK38226.2 - 9e-09 35.1 0.1 1.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 EDK38226.2 - 8.2e-06 25.8 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.19 EDK38226.2 - 0.0037 17.3 0.0 0.0072 16.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Mur_ligase_C PF02875.16 EDK38226.2 - 0.092 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain EamA PF00892.15 EDK38227.2 - 1.7e-06 28.0 43.3 5.1e-05 23.3 5.0 3.9 3 2 0 4 4 4 2 EamA-like transporter family EmrE PF13536.1 EDK38227.2 - 4.3e-05 23.6 4.4 4.3e-05 23.6 3.1 3.4 3 1 0 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 EDK38227.2 - 0.44 10.1 38.9 1 9.0 3.9 4.5 3 2 1 4 4 4 0 Triose-phosphate Transporter family Nuc_sug_transp PF04142.10 EDK38227.2 - 0.72 8.9 11.4 5.8 5.9 7.7 2.4 1 1 0 1 1 1 0 Nucleotide-sugar transporter ADH_zinc_N PF00107.21 EDK38229.2 - 1.2e-12 47.4 0.1 2.4e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK38229.2 - 1.8e-06 27.6 0.3 9.7e-06 25.3 0.1 2.2 1 1 2 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EDK38229.2 - 0.0055 17.5 0.2 0.016 16.0 0.1 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PRP38 PF03371.10 EDK38230.1 - 4.4e-53 179.4 1.3 5.1e-53 179.2 0.9 1.0 1 0 0 1 1 1 1 PRP38 family BAR_2 PF10455.4 EDK38231.2 - 2.8e-85 285.7 12.3 2.8e-85 285.7 8.6 1.6 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking NYD-SP28 PF14772.1 EDK38231.2 - 1 9.4 9.7 3.7 7.6 0.1 4.3 4 1 0 4 4 4 0 Sperm tail Arf PF00025.16 EDK38232.2 - 5.1e-37 126.7 1.3 3.1e-29 101.4 0.2 2.4 2 1 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.15 EDK38232.2 - 1.8e-12 46.7 0.6 3.9e-07 29.1 0.9 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 EDK38232.2 - 4.8e-10 39.9 0.1 3.7e-09 37.1 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein Ras PF00071.17 EDK38232.2 - 1.6e-09 37.3 0.1 7.9e-09 35.1 0.0 2.0 2 0 0 2 2 2 1 Ras family SRPRB PF09439.5 EDK38232.2 - 1.7e-07 30.6 0.0 0.00011 21.4 0.0 2.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 EDK38232.2 - 1.2e-06 28.1 0.0 2.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EDK38232.2 - 1.7e-06 27.3 0.1 1.6e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EDK38232.2 - 2.8e-05 24.0 0.0 5.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.1 EDK38232.2 - 0.0088 16.3 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain SAC3_GANP PF03399.11 EDK38232.2 - 0.012 15.2 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family AAA_22 PF13401.1 EDK38232.2 - 0.013 15.6 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 EDK38232.2 - 0.13 11.7 0.6 2.8 7.3 0.0 2.5 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain CDK5_activator PF03261.10 EDK38233.2 - 2.4 7.4 6.2 7.9 5.7 4.3 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ribosomal_L29e PF01779.12 EDK38234.1 - 1.1e-22 79.5 14.6 1.5e-22 79.1 10.1 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family YkuD PF03734.9 EDK38234.1 - 0.15 12.2 0.6 0.15 12.3 0.4 1.0 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain Ribosomal_L7Ae PF01248.21 EDK38235.1 - 8.7e-23 79.6 0.5 1.5e-22 78.9 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 EDK38235.1 - 0.0029 17.4 0.1 0.0046 16.8 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 PQ-loop PF04193.9 EDK38236.2 - 2.1e-29 100.8 3.3 6.9e-20 70.3 0.4 3.5 4 0 0 4 4 4 2 PQ loop repeat RseC_MucC PF04246.7 EDK38236.2 - 0.017 14.6 0.2 0.017 14.6 0.1 2.3 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC YrhC PF14143.1 EDK38236.2 - 0.033 14.1 0.1 0.033 14.1 0.0 2.1 3 0 0 3 3 3 0 YrhC-like protein UPF0640 PF15114.1 EDK38236.2 - 0.034 13.6 0.7 0.57 9.7 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family UPF0640 Adipogenin PF15202.1 EDK38236.2 - 0.073 12.9 0.6 1.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Adipogenin Arc_PepC_II PF06847.6 EDK38236.2 - 0.092 13.1 0.3 0.44 10.9 0.0 2.1 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II MtN3_slv PF03083.11 EDK38236.2 - 0.21 11.4 0.1 0.21 11.4 0.1 2.3 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange adh_short PF00106.20 EDK38237.2 - 2.5e-05 24.2 0.0 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Caveolin PF01146.12 EDK38237.2 - 0.043 13.3 0.2 0.39 10.2 0.0 2.2 2 1 0 2 2 2 0 Caveolin Anp1 PF03452.9 EDK38238.1 - 1.4e-120 401.5 0.0 1.7e-120 401.2 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glyco_tranf_2_4 PF13704.1 EDK38238.1 - 0.098 12.9 1.1 0.26 11.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 2 SMC_N PF02463.14 EDK38239.2 - 1.3e-68 230.5 18.3 1.1e-65 221.0 12.7 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EDK38239.2 - 9.4e-24 83.6 0.4 1.8e-22 79.5 0.1 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EDK38239.2 - 1.7e-18 67.6 3.6 1.7e-18 67.6 2.5 6.8 3 2 3 6 6 4 1 AAA domain AAA_21 PF13304.1 EDK38239.2 - 4.6e-08 33.3 40.2 0.0004 20.4 6.5 5.1 2 2 2 4 4 4 2 AAA domain HrpB7 PF09486.5 EDK38239.2 - 2.7e-06 27.4 5.4 2.7e-06 27.4 3.7 6.0 5 2 2 7 7 7 1 Bacterial type III secretion protein (HrpB7) EzrA PF06160.7 EDK38239.2 - 1.7e-05 23.2 29.9 1.7e-05 23.2 20.7 5.9 3 2 2 6 6 6 2 Septation ring formation regulator, EzrA AAA_29 PF13555.1 EDK38239.2 - 2.5e-05 23.6 0.0 6.6e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MscS_porin PF12795.2 EDK38239.2 - 0.00015 21.2 30.2 0.00015 21.2 21.0 6.2 5 1 1 6 6 6 2 Mechanosensitive ion channel porin domain WEMBL PF05701.6 EDK38239.2 - 0.00016 20.2 20.8 0.00016 20.2 14.4 4.3 2 2 2 4 4 3 2 Weak chloroplast movement under blue light AAA_13 PF13166.1 EDK38239.2 - 0.0011 17.6 36.0 0.0011 17.6 25.0 6.6 3 2 4 7 7 7 2 AAA domain Reo_sigmaC PF04582.7 EDK38239.2 - 0.0016 17.7 7.0 0.0016 17.7 4.8 6.2 2 2 5 8 8 8 2 Reovirus sigma C capsid protein Tropomyosin PF00261.15 EDK38239.2 - 0.0032 16.6 6.5 0.0032 16.6 4.5 7.9 2 2 4 6 6 6 2 Tropomyosin RNB PF00773.14 EDK38240.2 - 4.5e-54 183.9 0.3 4.5e-54 183.9 0.2 2.6 2 1 0 2 2 2 1 RNB domain Flocculin_t3 PF13928.1 EDK38241.2 - 5.1e-28 96.9 61.1 5.1e-14 52.1 12.4 6.2 4 2 1 5 5 5 3 Flocculin type 3 repeat DHC_N2 PF08393.8 EDK38241.2 - 0.071 11.6 0.0 0.099 11.1 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 Flocculin_t3 PF13928.1 EDK38242.1 - 2.6e-39 133.0 107.6 4.7e-14 52.2 12.7 5.8 5 2 0 5 5 5 4 Flocculin type 3 repeat FAD_binding_1 PF00667.15 EDK38243.2 - 3.6e-69 232.5 0.0 5.7e-69 231.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EDK38243.2 - 6e-10 39.6 0.0 1.8e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EDK38243.2 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain FAD_binding_4 PF01565.18 EDK38244.2 - 2.2e-25 88.7 0.0 3e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.14 EDK38245.2 - 1.4e-41 142.4 0.0 1.8e-41 142.1 0.0 1.0 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain YL1_C PF08265.6 EDK38246.2 - 1.7e-16 59.4 0.1 3e-16 58.6 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Sedlin_N PF04628.8 EDK38247.2 - 1.2e-12 47.8 0.1 1.7e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 EDK38247.2 - 0.037 13.7 0.0 0.043 13.5 0.0 1.1 1 0 0 1 1 1 0 Sybindin-like family Peptidase_M20 PF01546.23 EDK38248.2 - 7.9e-16 58.1 0.0 1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK38248.2 - 1.7e-08 34.1 0.0 3.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans PF04082.13 EDK38249.2 - 1.2e-17 63.7 0.4 2.1e-17 62.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 EDK38250.2 - 7.7e-23 80.7 13.0 7.7e-23 80.7 9.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK38250.2 - 6.8e-08 31.5 18.9 4.1e-07 28.9 5.5 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter DUF456 PF04306.8 EDK38250.2 - 0.0051 16.8 4.6 0.0051 16.8 3.2 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF456) NfeD PF01957.13 EDK38250.2 - 0.72 9.9 8.5 2.5 8.2 1.5 3.3 2 1 1 3 3 3 0 NfeD-like C-terminal, partner-binding Amidohydro_4 PF13147.1 EDK38251.1 - 1.5e-08 34.9 0.0 2.3e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 EDK38251.1 - 2.2e-05 24.3 0.0 4.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family FAD_binding_3 PF01494.14 EDK38252.2 - 1.5e-24 86.7 0.0 1.9e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EDK38252.2 - 2e-10 40.1 2.0 2.5e-06 26.6 1.7 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK38252.2 - 1.1e-06 27.7 3.3 2e-06 26.9 2.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 EDK38252.2 - 4.8e-06 25.2 0.2 1.1e-05 24.1 0.1 1.5 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 EDK38252.2 - 0.00012 22.3 0.6 0.0016 18.7 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EDK38252.2 - 0.00015 20.8 0.4 0.00093 18.2 0.3 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 EDK38252.2 - 0.00019 21.4 0.2 0.00034 20.5 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EDK38252.2 - 0.00078 18.4 0.0 0.00096 18.1 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 EDK38252.2 - 0.0017 18.3 0.9 0.0069 16.3 0.7 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EDK38252.2 - 0.0021 17.2 0.8 0.0033 16.5 0.6 1.3 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.19 EDK38252.2 - 0.0068 15.5 0.6 2.5 7.0 0.3 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_oxidored PF12831.2 EDK38252.2 - 0.0073 15.4 2.9 0.012 14.7 2.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EDK38252.2 - 0.041 13.9 1.6 0.16 11.9 0.4 2.3 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EDK38252.2 - 0.082 12.4 0.2 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.9 EDK38252.2 - 0.2 10.2 4.1 0.63 8.6 1.9 2.1 1 1 1 2 2 2 0 Tryptophan halogenase BAG PF02179.11 EDK38254.1 - 2.7e-23 81.8 2.6 2.7e-23 81.8 1.8 1.6 2 0 0 2 2 2 1 BAG domain Sec61_beta PF03911.11 EDK38254.1 - 0.066 13.0 0.9 0.12 12.1 0.6 1.4 1 0 0 1 1 1 0 Sec61beta family Gtr1_RagA PF04670.7 EDK38254.1 - 4.5 6.3 6.8 0.69 9.0 0.1 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region DOPA_dioxygen PF08883.6 EDK38255.1 - 9.4e-33 112.3 0.1 1.2e-32 112.1 0.1 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Peptidase_M1 PF01433.15 EDK38256.2 - 3.8e-71 240.2 0.0 6.9e-71 239.3 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 EDK38256.2 - 6.5e-40 136.0 0.2 1.2e-39 135.2 0.1 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 EDK38256.2 - 3.3e-15 56.2 0.1 6.2e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M48 PF01435.13 EDK38256.2 - 0.028 13.9 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M48 DnaJ-X PF14308.1 EDK38257.2 - 1.6e-57 194.1 25.4 2.3e-55 187.0 13.1 3.1 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 EDK38257.2 - 4.9e-25 87.0 1.1 4.9e-25 87.0 0.7 2.4 2 0 0 2 2 2 1 DnaJ domain Ribosomal_S5_C PF03719.10 EDK38258.1 - 1.1e-23 82.3 0.0 6.7e-23 79.7 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 EDK38258.1 - 1.3e-19 69.6 0.0 2.4e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF2838 PF10998.3 EDK38259.2 - 4.8e-40 135.9 15.1 4.8e-40 135.9 10.5 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) OmpH PF03938.9 EDK38259.2 - 0.0019 18.1 2.3 0.035 14.0 0.1 2.2 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) Ax_dynein_light PF10211.4 EDK38259.2 - 1.8 8.3 8.7 0.65 9.8 2.9 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain DUF4337 PF14235.1 EDK38259.2 - 2 8.2 6.8 1.1 9.0 1.9 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4337) Fib_alpha PF08702.5 EDK38259.2 - 3.8 7.6 6.5 0.79 9.8 1.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family MFS_1 PF07690.11 EDK38260.2 - 2.3e-13 49.5 26.8 2.3e-13 49.5 18.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 EDK38260.2 - 0.0012 18.6 2.0 2.2 8.1 0.0 3.9 3 0 0 3 3 3 2 MFS_1 like family fn3 PF00041.16 EDK38261.2 - 2e-06 27.8 0.5 6.5e-06 26.2 0.2 2.0 2 0 0 2 2 1 1 Fibronectin type III domain CBM49 PF09478.5 EDK38261.2 - 0.0096 16.0 0.5 0.024 14.7 0.4 1.7 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 Herpes_UL37_2 PF07413.6 EDK38261.2 - 0.015 14.0 1.8 0.026 13.3 1.2 1.3 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 Reo_sigmaC PF04582.7 EDK38261.2 - 0.18 10.9 2.5 0.39 9.8 0.9 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Syntaxin PF00804.20 EDK38261.2 - 0.3 11.2 16.5 0.52 10.5 6.1 2.6 2 0 0 2 2 2 0 Syntaxin PRF PF06875.6 EDK38261.2 - 1.4 8.1 6.1 0.52 9.4 0.1 2.9 3 1 0 3 3 3 0 Plethodontid receptivity factor PRF COG2 PF06148.6 EDK38261.2 - 2.7 7.8 12.4 0.36 10.7 2.4 2.6 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HlyD PF00529.15 EDK38261.2 - 2.8 7.1 9.5 6.2 6.0 6.6 1.5 1 0 0 1 1 1 0 HlyD family secretion protein CENP-F_leu_zip PF10473.4 EDK38261.2 - 3.1 7.6 24.4 2.9 7.7 13.3 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lge1 PF11488.3 EDK38261.2 - 4.8 7.4 12.1 35 4.6 0.2 3.6 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Cortex-I_coil PF09304.5 EDK38261.2 - 9.5 6.3 21.1 27 4.8 2.4 2.8 1 1 1 2 2 2 0 Cortexillin I, coiled coil Beta_elim_lyase PF01212.16 EDK38262.1 - 9.6e-80 267.8 0.0 1.2e-79 267.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 EDK38262.1 - 1.2e-05 24.4 0.0 1.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 EDK38262.1 - 0.032 13.2 0.0 0.07 12.1 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.11 EDK38263.2 - 8.8e-36 123.3 24.2 8.8e-36 123.3 16.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK38263.2 - 2.1e-15 56.2 21.9 3.4e-15 55.5 15.2 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.8 EDK38263.2 - 9.7e-05 20.7 1.4 0.00016 20.0 1.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Alk_phosphatase PF00245.15 EDK38264.2 - 1.8e-111 372.8 0.0 2.4e-111 372.4 0.0 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 EDK38264.2 - 0.00018 20.9 0.0 0.0007 19.0 0.0 1.8 2 0 0 2 2 2 1 Metalloenzyme superfamily OCD_Mu_crystall PF02423.10 EDK38265.2 - 1.2e-10 40.6 0.1 5e-10 38.6 0.1 1.7 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.15 EDK38265.2 - 0.00015 21.8 0.1 0.00028 21.0 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ABC_sub_bind PF04392.7 EDK38265.2 - 0.018 13.9 0.1 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 ABC transporter substrate binding protein Peptidase_C1_2 PF03051.10 EDK38265.2 - 0.045 12.2 0.0 0.068 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase C1-like family SUI1 PF01253.17 EDK38265.2 - 0.056 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor SUI1 DUF4473 PF14747.1 EDK38265.2 - 0.16 12.1 1.0 16 5.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) Gpi1 PF05024.10 EDK38267.2 - 7.9e-44 149.5 8.1 7.9e-44 149.5 5.6 2.5 3 0 0 3 3 3 1 N-acetylglucosaminyl transferase component (Gpi1) TcpE PF12648.2 EDK38269.2 - 0.027 14.6 3.1 0.17 12.0 0.7 2.2 2 0 0 2 2 2 0 TcpE family MFS_1 PF07690.11 EDK38270.2 - 2.9e-10 39.4 9.7 8e-10 37.9 6.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK38271.2 - 4.5e-10 38.7 31.2 1.7e-08 33.5 8.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S2 PF00318.15 EDK38272.1 - 1.1e-40 139.0 0.1 1.5e-21 76.5 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 SMI1_KNR4 PF09346.5 EDK38273.2 - 1.1e-40 138.6 0.0 2.4e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) DIE2_ALG10 PF04922.7 EDK38274.2 - 2.8e-91 306.3 26.0 4e-91 305.8 18.0 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family WD40 PF00400.27 EDK38276.2 - 5.3e-07 29.2 9.2 0.0022 17.8 0.1 3.7 4 0 0 4 4 4 3 WD domain, G-beta repeat LVIVD PF08309.6 EDK38276.2 - 0.09 11.7 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 LVIVD repeat SH3_1 PF00018.23 EDK38277.2 - 1.3e-11 43.6 0.1 2.5e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EDK38277.2 - 5e-11 41.9 0.0 7.4e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EDK38277.2 - 1.3e-10 40.6 0.1 3e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PAT1 PF09770.4 EDK38277.2 - 0.2 9.8 13.5 0.22 9.7 9.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PRCC PF10253.4 EDK38277.2 - 0.48 11.0 6.5 1.5 9.5 2.4 2.2 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Band_7 PF01145.20 EDK38278.1 - 7.9e-22 78.0 2.8 1.2e-21 77.3 1.9 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 EDK38278.1 - 0.0074 15.8 0.6 0.014 14.9 0.4 1.4 1 1 0 1 1 1 1 Enhancer of Polycomb C-terminus DUF3416 PF11896.3 EDK38278.1 - 0.087 12.7 1.0 0.14 12.0 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) Lectin_C PF00059.16 EDK38279.2 - 0.021 15.4 3.1 0.045 14.4 0.2 2.7 3 0 0 3 3 3 0 Lectin C-type domain Methyltransf_27 PF13708.1 EDK38279.2 - 0.26 10.7 2.3 0.22 11.0 0.2 2.0 2 0 0 2 2 2 0 Methyltransferase domain UvrD_C PF13361.1 EDK38280.2 - 3.4e-70 237.2 0.5 3.4e-70 237.2 0.3 1.8 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 EDK38280.2 - 4.6e-57 193.7 1.0 4.6e-57 193.7 0.7 3.1 2 2 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 EDK38280.2 - 7.1e-14 51.3 0.1 2e-13 49.8 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 EDK38280.2 - 8.1e-11 41.9 0.0 4.7e-10 39.5 0.0 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.1 EDK38280.2 - 1.4e-07 31.3 4.7 5e-07 29.5 3.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EDK38280.2 - 3.6e-05 23.4 0.0 0.00012 21.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.9 EDK38280.2 - 0.00093 18.8 0.0 0.016 14.8 0.0 2.7 2 0 0 2 2 2 1 Helicase Viral_helicase1 PF01443.13 EDK38280.2 - 0.0023 17.5 1.1 4.9 6.5 0.1 3.7 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 EDK38280.2 - 0.016 14.7 0.1 0.056 12.9 0.1 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF2117 PF09890.4 EDK38280.2 - 0.051 12.7 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) PhoH PF02562.11 EDK38280.2 - 0.065 12.4 0.1 0.45 9.7 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.10 EDK38280.2 - 0.14 11.9 1.5 1.3 8.8 0.1 2.9 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Rho_GDI PF02115.12 EDK38281.2 - 3.6e-53 179.9 0.6 4e-53 179.8 0.4 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Filamin PF00630.14 EDK38281.2 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Filamin/ABP280 repeat Ufd2P_core PF10408.4 EDK38282.2 - 2.1e-202 673.7 4.7 2.8e-202 673.3 3.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 EDK38282.2 - 6.8e-27 93.2 1.7 2.8e-26 91.2 0.9 2.3 2 0 0 2 2 2 1 U-box domain Arf PF00025.16 EDK38283.1 - 3.1e-80 267.5 0.0 3.7e-80 267.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EDK38283.1 - 2.8e-14 52.7 0.0 3.5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EDK38283.1 - 2.2e-13 49.9 0.0 2.4e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EDK38283.1 - 1.1e-11 44.0 0.9 8.8e-09 34.5 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 EDK38283.1 - 3.4e-11 42.7 0.0 4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 EDK38283.1 - 1.4e-08 35.2 0.0 1.9e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EDK38283.1 - 4e-05 23.5 0.0 5.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 EDK38283.1 - 0.0049 15.9 0.3 0.0082 15.2 0.2 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 EDK38283.1 - 0.028 13.8 0.1 0.19 11.1 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.1 EDK38283.1 - 0.081 12.7 0.1 0.14 12.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK38283.1 - 0.11 11.9 0.1 1.8 8.0 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Radical_SAM PF04055.16 EDK38284.2 - 6.7e-13 49.1 0.0 1e-12 48.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily NUDIX PF00293.23 EDK38285.1 - 8.9e-27 93.3 0.0 1.3e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DivIC PF04977.10 EDK38286.2 - 0.014 14.8 7.9 0.014 14.8 5.5 6.0 3 2 3 6 6 6 0 Septum formation initiator CRT10 PF08728.5 EDK38286.2 - 1.9 6.3 9.0 2.5 5.9 6.2 1.2 1 0 0 1 1 1 0 CRT10 UPF0184 PF03670.8 EDK38286.2 - 9.1 6.5 10.4 2.6 8.2 0.8 3.5 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0184) Methyltrn_RNA_3 PF02598.12 EDK38287.2 - 1.8e-77 260.5 0.4 2e-77 260.4 0.2 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase OapA PF04225.7 EDK38287.2 - 0.023 14.6 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain Glyco_hydro_17 PF00332.13 EDK38288.2 - 7.9e-68 228.7 4.1 9.1e-68 228.5 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 polyprenyl_synt PF00348.12 EDK38288.2 - 0.043 12.6 0.0 0.68 8.7 0.0 2.0 2 0 0 2 2 2 0 Polyprenyl synthetase Glyco_hydro_16 PF00722.16 EDK38289.2 - 2.3e-46 157.3 0.5 2.3e-46 157.3 0.3 2.4 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 DUF605 PF04652.11 EDK38289.2 - 2.7 7.3 28.1 3.9 6.7 19.5 1.1 1 0 0 1 1 1 0 Vta1 like SPRY PF00622.23 EDK38290.2 - 5.8e-13 49.0 0.0 9.9e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain DUF3445 PF11927.3 EDK38292.2 - 1.8e-77 260.1 0.5 2.1e-77 259.8 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) SH3_1 PF00018.23 EDK38293.2 - 3.6e-24 83.8 7.2 8.6e-13 47.4 0.5 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 EDK38293.2 - 2.2e-23 81.5 5.3 2.4e-11 43.0 0.4 2.7 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.15 EDK38293.2 - 4.1e-21 75.1 0.0 7.4e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.12 EDK38293.2 - 2.1e-13 49.5 0.6 1.5e-06 27.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain zf-UBR PF02207.15 EDK38294.2 - 1e-17 63.5 10.1 4.1e-17 61.6 7.0 2.1 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-RING_2 PF13639.1 EDK38294.2 - 0.00048 19.9 0.3 0.00048 19.9 0.2 3.8 3 1 1 4 4 4 1 Ring finger domain ClpS PF02617.12 EDK38294.2 - 0.069 12.8 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS zf-C3HC4_2 PF13923.1 EDK38295.2 - 0.00061 19.7 1.5 0.00061 19.7 1.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK38295.2 - 0.0013 18.4 1.8 0.0013 18.4 1.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EDK38295.2 - 0.0019 17.8 1.8 0.0064 16.1 1.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38295.2 - 0.0097 15.6 1.4 0.0097 15.6 1.0 2.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-rbx1 PF12678.2 EDK38295.2 - 0.018 15.1 0.3 0.018 15.1 0.2 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger UAA PF08449.6 EDK38295.2 - 0.24 10.2 0.0 0.43 9.4 0.0 1.3 1 0 0 1 1 1 0 UAA transporter family zf-UBR PF02207.15 EDK38296.2 - 1.8e-17 62.8 12.2 3e-17 62.0 8.4 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 EDK38296.2 - 1.7e-07 30.8 0.0 1.6e-06 27.7 0.0 2.3 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS tRNA-synt_1b PF00579.20 EDK38297.1 - 1.5e-72 244.1 0.0 2.1e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) SBDS_C PF09377.5 EDK38298.1 - 5.7e-38 129.4 3.3 5.7e-38 129.4 2.3 1.5 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.13 EDK38298.1 - 1.3e-33 114.6 1.4 2.7e-33 113.5 0.9 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein HTH_22 PF13309.1 EDK38298.1 - 0.025 14.3 0.1 0.097 12.4 0.1 2.0 1 0 0 1 1 1 0 HTH domain DnaJ PF00226.26 EDK38299.2 - 5.7e-17 61.2 0.1 5.7e-17 61.2 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain Acyl-CoA_dh_1 PF00441.19 EDK38299.2 - 0.29 11.2 6.2 0.53 10.3 4.3 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Rtf2 PF04641.7 EDK38299.2 - 8.2 5.5 18.3 18 4.4 12.7 1.6 1 0 0 1 1 1 0 Rtf2 RING-finger IPP-2 PF04979.9 EDK38300.2 - 1.1e-09 38.6 18.1 1.2e-09 38.5 9.0 2.7 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Sigma70_ner PF04546.8 EDK38300.2 - 4 6.9 13.1 0.12 11.9 3.7 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Arf PF00025.16 EDK38301.1 - 1.6e-75 252.1 0.3 1.8e-75 252.0 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 EDK38301.1 - 2.8e-12 46.2 0.0 3.3e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 EDK38301.1 - 5.1e-11 42.1 0.0 6e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 EDK38301.1 - 9.8e-11 41.3 0.0 1.1e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 EDK38301.1 - 2.8e-10 39.4 0.8 1.5e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 EDK38301.1 - 1.3e-09 38.5 0.0 1.8e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EDK38301.1 - 0.00013 21.8 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.11 EDK38301.1 - 0.0005 18.9 1.3 0.073 11.8 0.0 2.9 2 1 1 3 3 3 1 ArgK protein GTP_EFTU PF00009.22 EDK38301.1 - 0.0012 18.2 0.2 0.024 14.0 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.22 EDK38301.1 - 0.0016 18.7 0.4 0.0055 16.9 0.3 1.8 1 1 0 1 1 1 1 ABC transporter cobW PF02492.14 EDK38301.1 - 0.015 14.7 0.7 3.9 6.8 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.17 EDK38301.1 - 0.098 12.0 0.5 0.5 9.7 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.7 EDK38301.1 - 0.13 11.9 0.3 5.6 6.5 0.1 2.2 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.4 EDK38301.1 - 0.14 11.6 0.1 1 8.8 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PDH PF02153.12 EDK38303.2 - 1.5e-13 50.2 0.0 2e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.12 EDK38303.2 - 1.6e-07 31.6 0.0 3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 EDK38303.2 - 2.1e-06 27.0 0.0 4.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 EDK38303.2 - 2.3e-06 27.5 0.0 4.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 EDK38303.2 - 0.0003 20.2 0.0 0.0005 19.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.7 EDK38303.2 - 0.0067 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 3HCDH_N PF02737.13 EDK38303.2 - 0.012 15.2 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.4 EDK38303.2 - 0.035 13.8 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain TrkA_N PF02254.13 EDK38303.2 - 0.053 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.9 EDK38303.2 - 0.095 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GHMP_kinases_N PF00288.21 EDK38304.2 - 3.5e-08 33.3 0.4 1.3e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain zf-LITAF-like PF10601.4 EDK38304.2 - 0.021 14.6 0.9 0.08 12.8 0.6 2.0 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain GHMP_kinases_C PF08544.8 EDK38305.2 - 8.1e-08 32.3 0.0 2.3e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 GHMP kinases C terminal DUF3419 PF11899.3 EDK38305.2 - 0.12 11.0 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) Neugrin PF06413.6 EDK38305.2 - 0.13 12.0 0.1 0.31 10.8 0.0 1.6 2 0 0 2 2 2 0 Neugrin DUF4448 PF14610.1 EDK38307.2 - 0.034 13.6 0.4 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF2613 PF11021.3 EDK38307.2 - 0.1 12.2 0.3 0.29 10.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) WBP-1 PF11669.3 EDK38307.2 - 0.47 10.5 2.4 2.2 8.3 1.7 2.2 1 0 0 1 1 1 0 WW domain-binding protein 1 Peptidase_M20 PF01546.23 EDK38308.2 - 1.7e-23 83.1 0.0 2.4e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK38308.2 - 1e-11 44.5 0.0 2.1e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF383 PF04063.9 EDK38309.1 - 3.5e-76 255.0 0.4 9.6e-76 253.6 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF383) DUF384 PF04064.8 EDK38309.1 - 0.00025 20.5 0.6 0.00058 19.3 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Muskelin_N PF06588.6 EDK38309.1 - 0.074 12.7 0.5 0.13 11.9 0.4 1.3 1 0 0 1 1 1 0 Muskelin N-terminus TFIIF_alpha PF05793.7 EDK38310.2 - 2.5e-22 78.9 28.1 6.5e-12 44.5 8.9 3.2 1 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4048 PF13257.1 EDK38310.2 - 0.13 11.8 8.7 0.27 10.8 6.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) Vac7 PF12751.2 EDK38310.2 - 0.19 10.5 4.7 0.091 11.5 1.2 1.9 1 1 0 1 1 1 0 Vacuolar segregation subunit 7 YjgP_YjgQ PF03739.9 EDK38310.2 - 0.47 9.1 1.4 0.75 8.4 0.6 1.6 1 1 1 2 2 2 0 Predicted permease YjgP/YjgQ family Mito_carr PF00153.22 EDK38311.1 - 2.4e-55 184.2 1.3 1.1e-18 66.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mannosyl_trans PF05007.8 EDK38313.2 - 3.2e-75 253.1 25.6 5.1e-75 252.4 17.7 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 EDK38313.2 - 2.3e-14 53.0 10.4 2.3e-14 53.0 7.2 2.1 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 EDK38313.2 - 2.6e-05 23.8 7.3 2.6e-05 23.8 5.1 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2029) RNase_PH PF01138.16 EDK38314.2 - 6.3e-31 107.4 0.4 8.3e-31 107.0 0.3 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EDK38314.2 - 4.7e-06 26.4 0.1 1.1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SURF4 PF02077.10 EDK38315.2 - 5.7e-91 304.5 12.7 6.6e-91 304.3 8.8 1.0 1 0 0 1 1 1 1 SURF4 family VirB8 PF04335.8 EDK38315.2 - 0.014 15.0 0.6 0.029 13.9 0.4 1.6 1 0 0 1 1 1 0 VirB8 protein HR_lesion PF05514.6 EDK38315.2 - 0.46 10.2 14.9 0.072 12.9 6.4 2.5 3 0 0 3 3 3 0 HR-like lesion-inducing zf-Tim10_DDP PF02953.10 EDK38316.2 - 4e-22 77.2 4.7 5.6e-22 76.8 3.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 EDK38316.2 - 0.023 14.1 3.7 0.033 13.6 2.6 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DUF1275 PF06912.6 EDK38316.2 - 0.051 12.7 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) Kelch_6 PF13964.1 EDK38317.2 - 1.5e-06 28.1 5.8 1.9 8.7 0.0 6.4 6 2 1 7 7 7 3 Kelch motif Kelch_4 PF13418.1 EDK38317.2 - 0.00025 20.7 0.1 0.00025 20.7 0.1 6.0 7 0 0 7 7 7 1 Galactose oxidase, central domain Kelch_3 PF13415.1 EDK38317.2 - 0.0012 18.9 2.5 4.7 7.4 0.0 5.5 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 EDK38317.2 - 0.042 13.6 5.3 0.53 10.1 0.0 5.1 7 0 0 7 7 7 0 Kelch motif ABC1 PF03109.11 EDK38318.2 - 8.2e-24 83.8 0.1 4e-15 55.8 0.0 2.6 2 0 0 2 2 2 2 ABC1 family RIO1 PF01163.17 EDK38318.2 - 0.00056 19.3 0.1 0.0014 17.9 0.1 1.7 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 EDK38318.2 - 0.084 12.5 0.2 0.19 11.4 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Aldedh PF00171.17 EDK38319.1 - 5.3e-179 595.3 0.3 6e-179 595.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EDK38319.1 - 0.028 13.6 0.1 1.3 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) SNF2_N PF00176.18 EDK38320.2 - 1.7e-70 237.1 0.0 2.3e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK38320.2 - 7.8e-12 44.8 0.0 1.5e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.20 EDK38320.2 - 3.2e-07 29.9 10.5 3.2e-07 29.9 7.3 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.10 EDK38320.2 - 1.6e-06 28.1 0.0 3.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK38320.2 - 4.1e-06 26.3 0.0 7.8e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.1 EDK38320.2 - 0.00092 19.1 11.0 0.00092 19.1 7.6 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK38320.2 - 0.0016 18.1 11.1 0.0016 18.1 7.7 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 EDK38320.2 - 0.0036 16.9 9.5 0.0036 16.9 6.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK38320.2 - 0.013 15.3 11.0 0.013 15.3 7.6 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING WD40 PF00400.27 EDK38321.2 - 6.9e-28 95.4 2.3 5.5e-08 32.3 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat PQQ_2 PF13360.1 EDK38321.2 - 0.008 15.6 0.1 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 PQQ-like domain SdiA-regulated PF06977.6 EDK38321.2 - 0.067 12.1 0.1 2.2 7.1 0.0 2.5 3 0 0 3 3 3 0 SdiA-regulated Nup160 PF11715.3 EDK38321.2 - 0.072 11.2 0.0 0.21 9.6 0.0 1.6 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DLH PF01738.13 EDK38323.2 - 3.5e-34 118.0 0.0 4e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EDK38323.2 - 1.6e-07 31.2 0.0 2.2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 EDK38323.2 - 0.00082 18.8 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) BAAT_C PF08840.6 EDK38323.2 - 0.0021 17.8 0.1 0.008 15.8 0.0 1.8 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.16 EDK38323.2 - 0.024 13.8 0.0 0.086 12.0 0.0 2.0 1 1 0 1 1 1 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 EDK38323.2 - 0.041 12.7 0.0 0.06 12.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S15 PF02129.13 EDK38323.2 - 0.049 13.0 0.0 0.07 12.5 0.0 1.4 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 EDK38323.2 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase ArsA_ATPase PF02374.10 EDK38324.2 - 1.5e-108 362.4 0.1 1.7e-108 362.2 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 EDK38324.2 - 5.4e-10 38.9 0.0 8.8e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EDK38324.2 - 0.00018 21.5 0.0 0.00057 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 EDK38324.2 - 0.0021 16.9 0.0 0.0038 16.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Fer4_NifH PF00142.13 EDK38324.2 - 0.0054 15.9 0.1 0.013 14.6 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Zeta_toxin PF06414.7 EDK38324.2 - 0.014 14.4 0.0 0.041 12.9 0.0 1.9 1 0 0 1 1 1 0 Zeta toxin SRP54 PF00448.17 EDK38324.2 - 0.023 14.1 0.4 0.12 11.8 0.0 2.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_25 PF13481.1 EDK38324.2 - 0.071 12.5 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EDK38324.2 - 0.072 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_10 PF12846.2 EDK38324.2 - 0.091 12.1 0.1 0.21 10.9 0.1 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_19 PF13245.1 EDK38324.2 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain SPX PF03105.14 EDK38325.2 - 9.8e-43 146.8 16.9 1.5e-42 146.3 11.7 1.3 1 0 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.1 EDK38325.2 - 7.8e-10 38.4 11.7 1.2e-09 37.8 6.8 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 EDK38325.2 - 1.9e-09 37.1 8.4 3.9e-09 36.2 5.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK38325.2 - 1.1e-08 34.8 11.0 2.4e-08 33.8 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK38325.2 - 2.8e-07 30.0 9.8 2.8e-07 30.0 6.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK38325.2 - 3.6e-07 29.7 8.7 6.4e-07 28.9 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38325.2 - 3.3e-06 26.7 9.4 1.2e-05 24.9 6.6 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 EDK38325.2 - 2.2e-05 24.0 11.9 2.7e-05 23.7 6.8 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.1 EDK38325.2 - 0.002 17.6 3.3 0.002 17.6 2.3 2.2 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Mor PF08765.6 EDK38325.2 - 0.043 13.5 0.6 0.84 9.4 0.0 2.9 3 0 0 3 3 3 0 Mor transcription activator family zf-MIZ PF02891.15 EDK38325.2 - 0.046 13.2 7.0 0.093 12.2 4.8 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Apc11 PF12861.2 EDK38325.2 - 0.058 13.2 2.3 0.12 12.2 1.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 EDK38325.2 - 0.061 13.4 5.5 0.16 12.1 3.8 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_6 PF14835.1 EDK38325.2 - 0.074 12.8 3.2 0.17 11.6 2.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GAGA PF09237.6 EDK38325.2 - 0.71 9.5 3.0 8.5 6.0 0.4 2.5 2 0 0 2 2 2 0 GAGA factor ThiF PF00899.16 EDK38326.2 - 1.2e-09 38.0 0.0 5.2e-09 36.0 0.0 2.0 2 0 0 2 2 2 1 ThiF family FTA2 PF13095.1 EDK38326.2 - 0.11 12.0 2.2 0.44 10.1 1.5 1.9 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DEAD PF00270.24 EDK38327.2 - 1.4e-41 141.8 2.7 1.1e-40 138.8 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK38327.2 - 8.2e-22 76.8 0.0 4.2e-21 74.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 EDK38327.2 - 3e-19 68.3 0.2 5.5e-19 67.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 EDK38327.2 - 0.0021 17.9 0.0 0.0021 17.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 EDK38327.2 - 0.0046 16.2 3.4 1.1 8.5 0.0 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain SecA_DEAD PF07517.9 EDK38327.2 - 0.045 13.0 2.1 14 4.8 0.0 2.9 2 1 1 3 3 3 0 SecA DEAD-like domain DUF1168 PF06658.7 EDK38327.2 - 5.8 6.4 21.5 10 5.6 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PseudoU_synth_1 PF01416.15 EDK38328.2 - 1.6e-34 118.4 0.0 8.8e-23 80.7 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase EAP30 PF04157.11 EDK38329.2 - 1.3e-37 129.0 0.0 1.5e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DUF4253 PF14062.1 EDK38329.2 - 0.075 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) Y_phosphatase3 PF13350.1 EDK38330.2 - 3e-46 157.6 0.0 6e-46 156.6 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_6 PF12697.2 EDK38330.2 - 8.4e-13 48.7 0.0 2.1e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK38330.2 - 1.5e-12 47.4 0.0 2.6e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Y_phosphatase3C PF13348.1 EDK38330.2 - 8.8e-11 41.7 0.0 2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Y_phosphatase2 PF03162.8 EDK38330.2 - 2.7e-06 26.8 0.0 5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 EDK38330.2 - 3.5e-05 23.2 0.0 6.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.9 EDK38330.2 - 0.002 16.9 0.0 0.0031 16.3 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.15 EDK38330.2 - 0.0021 17.6 0.1 0.0081 15.7 0.1 1.9 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 EDK38330.2 - 0.0029 17.6 0.1 0.0069 16.4 0.1 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Hydrolase_4 PF12146.3 EDK38330.2 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DUF1749 PF08538.5 EDK38330.2 - 0.0066 15.3 0.0 0.018 13.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.16 EDK38330.2 - 0.031 13.5 0.0 0.7 9.0 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ctf8 PF09696.5 EDK38331.2 - 2.2e-34 117.8 0.0 2.7e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Ctf8 Poxvirus_B22R_C PF13168.1 EDK38331.2 - 0.12 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal DUF3112 PF11309.3 EDK38332.1 - 2.4e-53 180.2 3.8 2.4e-53 180.2 2.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3112) RTA1 PF04479.8 EDK38332.1 - 0.0053 16.2 0.5 0.0053 16.2 0.3 2.7 3 1 0 3 3 3 1 RTA1 like protein DUF3112 PF11309.3 EDK38333.1 - 3.7e-27 95.0 2.4 3.7e-27 95.0 1.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3112) DUF3112 PF11309.3 EDK38334.2 - 4.2e-25 88.4 1.0 5.9e-25 87.9 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3112) Chs3p PF12271.3 EDK38334.2 - 0.024 13.5 1.3 0.03 13.3 0.9 1.1 1 0 0 1 1 1 0 Chitin synthase III catalytic subunit Tmemb_cc2 PF10267.4 EDK38334.2 - 1.4 7.4 3.2 10 4.5 0.2 2.0 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Pyr_redox_2 PF07992.9 EDK38335.2 - 4.3e-23 82.2 0.1 3.6e-15 56.3 0.0 3.5 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK38335.2 - 2.5e-10 40.5 0.4 2.6e-09 37.3 0.0 2.8 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK38335.2 - 0.00019 21.5 0.5 0.12 12.4 0.1 3.3 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EDK38335.2 - 0.11 12.4 0.1 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Mod_r PF07200.8 EDK38336.2 - 1.4e-09 38.0 12.1 1.9e-09 37.5 8.4 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Spore_II_R PF09551.5 EDK38336.2 - 0.0026 17.7 3.3 0.0034 17.4 2.0 1.3 1 1 0 1 1 1 1 Stage II sporulation protein R (spore_II_R) DHC_N1 PF08385.7 EDK38336.2 - 0.012 13.9 9.2 0.016 13.6 6.4 1.0 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 DUF3410 PF11890.3 EDK38336.2 - 0.016 14.7 0.2 0.039 13.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) Med9 PF07544.8 EDK38336.2 - 0.031 14.0 0.7 0.031 14.0 0.5 2.3 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 GP41 PF00517.12 EDK38336.2 - 0.031 13.8 8.9 0.057 12.9 6.2 1.3 1 0 0 1 1 1 0 Retroviral envelope protein DUF148 PF02520.12 EDK38336.2 - 0.085 12.6 8.2 0.061 13.1 2.4 2.2 1 1 0 2 2 2 0 Domain of unknown function DUF148 PhaP_Bmeg PF09602.5 EDK38336.2 - 0.12 12.1 9.8 0.34 10.7 6.8 1.7 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF2203 PF09969.4 EDK38336.2 - 0.13 12.4 2.0 0.25 11.5 1.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.8 EDK38336.2 - 0.14 11.1 7.5 0.042 12.9 2.6 1.7 1 1 1 2 2 2 0 TMPIT-like protein Laminin_II PF06009.7 EDK38336.2 - 0.16 11.7 2.4 0.54 10.0 0.4 2.1 2 0 0 2 2 2 0 Laminin Domain II Sec8_exocyst PF04048.9 EDK38336.2 - 0.16 11.5 5.8 0.097 12.3 1.3 2.1 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain SecA_DEAD PF07517.9 EDK38336.2 - 0.16 11.1 2.4 0.15 11.3 1.0 1.4 1 1 0 1 1 1 0 SecA DEAD-like domain DUF4298 PF14131.1 EDK38336.2 - 0.17 11.8 6.5 0.5 10.2 1.9 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4298) Syntaxin-6_N PF09177.6 EDK38336.2 - 0.18 12.2 6.4 2 8.8 1.9 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal IFT46_B_C PF12317.3 EDK38336.2 - 0.21 10.9 3.8 0.33 10.2 2.4 1.5 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal DUF745 PF05335.8 EDK38336.2 - 0.28 10.6 2.8 0.37 10.2 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DivIC PF04977.10 EDK38336.2 - 0.32 10.5 7.2 4.2 6.9 0.1 2.6 2 1 0 2 2 2 0 Septum formation initiator zf-C4H2 PF10146.4 EDK38336.2 - 0.46 10.4 7.9 1.3 8.9 4.8 1.8 1 1 1 2 2 2 0 Zinc finger-containing protein Fib_alpha PF08702.5 EDK38336.2 - 0.51 10.4 6.1 1.5 8.9 1.7 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Dna2 PF08696.6 EDK38336.2 - 0.96 8.7 5.0 1.1 8.5 1.9 1.8 1 1 1 2 2 2 0 DNA replication factor Dna2 FUSC-like PF12805.2 EDK38336.2 - 1.2 8.0 5.8 2 7.2 4.0 1.5 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS Seryl_tRNA_N PF02403.17 EDK38336.2 - 1.4 8.9 6.6 2.8 8.0 1.9 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.6 EDK38336.2 - 1.6 8.4 8.7 9.8 5.9 2.9 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4559 PF15112.1 EDK38336.2 - 2.3 7.2 9.6 0.81 8.7 2.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) BLOC1_2 PF10046.4 EDK38336.2 - 2.7 8.1 9.3 1.7 8.8 4.0 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 EDK38336.2 - 8 5.9 7.2 13 5.3 5.0 1.5 1 1 0 1 1 1 0 IncA protein MFS_1 PF07690.11 EDK38337.2 - 1.9e-38 132.1 29.6 1.9e-38 132.1 20.5 2.0 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF3589 PF12141.3 EDK38338.2 - 2.5e-154 514.2 0.4 3.2e-154 513.8 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) CBM_17_28 PF03424.9 EDK38338.2 - 0.11 12.0 0.1 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 17/28) Ank_3 PF13606.1 EDK38339.2 - 1.7e-14 52.4 1.1 0.00039 20.3 0.1 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 EDK38339.2 - 1.8e-14 53.8 0.1 0.00014 22.2 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK38339.2 - 3e-11 43.4 0.3 9.2e-05 22.7 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 EDK38339.2 - 6.9e-10 38.2 0.1 0.025 14.3 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 EDK38339.2 - 2.3e-07 30.8 0.4 0.12 12.6 0.0 4.6 4 1 1 5 5 5 3 Ankyrin repeats (many copies) KilA-N PF04383.8 EDK38339.2 - 2.3e-06 27.1 0.1 2.3e-06 27.1 0.0 2.8 3 1 0 3 3 3 1 KilA-N domain DUF2296 PF10058.4 EDK38341.2 - 9.6e-21 73.2 0.1 1.8e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) DUF1610 PF07754.6 EDK38341.2 - 0.0028 17.7 0.8 0.0079 16.2 0.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1610) SecY PF00344.15 EDK38341.2 - 0.0093 14.9 3.1 0.013 14.4 2.2 1.1 1 0 0 1 1 1 1 SecY translocase DUF4577 PF15145.1 EDK38341.2 - 0.051 13.4 0.3 0.17 11.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) NAC PF01849.13 EDK38342.1 - 5e-20 70.7 0.1 7.8e-20 70.1 0.1 1.3 1 0 0 1 1 1 1 NAC domain AcylCoA_dehyd_C PF12186.3 EDK38342.1 - 0.035 13.9 0.1 0.072 12.9 0.1 1.5 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal E1-E2_ATPase PF00122.15 EDK38343.2 - 3.8e-18 65.3 0.1 1.4e-16 60.2 0.0 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 EDK38343.2 - 1.7e-13 51.4 0.1 2.5e-06 28.0 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK38343.2 - 1.8e-12 47.8 0.0 9.8e-12 45.4 0.0 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK38343.2 - 2.4e-10 40.2 0.0 6.7e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EDK38343.2 - 0.00081 19.0 1.8 0.00088 18.9 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CPSF100_C PF13299.1 EDK38344.2 - 2.8e-40 138.1 2.9 5.5e-39 133.9 0.0 2.5 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 EDK38344.2 - 8.3e-23 80.6 0.0 2.6e-22 79.0 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain zf-CCHC PF00098.18 EDK38345.2 - 7.4e-06 25.6 0.6 1.2e-05 24.9 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle KH_1 PF00013.24 EDK38345.2 - 1.7e-05 24.3 0.1 6.1e-05 22.5 0.1 1.8 1 1 0 1 1 1 1 KH domain KH_3 PF13014.1 EDK38345.2 - 3.2e-05 23.4 0.7 6.4e-05 22.4 0.1 1.9 2 0 0 2 2 2 1 KH domain zf-CCHC_3 PF13917.1 EDK38345.2 - 0.013 15.2 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.1 EDK38345.2 - 0.25 10.8 2.0 0.63 9.5 0.5 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Methyltransf_26 PF13659.1 EDK38346.2 - 7.7e-13 48.5 0.0 1.1e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK38346.2 - 7.7e-07 28.6 0.0 1e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 EDK38346.2 - 0.0035 16.9 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK38346.2 - 0.037 14.4 0.0 0.79 10.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF938 PF06080.7 EDK38346.2 - 0.064 12.7 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) DUF2431 PF10354.4 EDK38346.2 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2431) ubiquitin PF00240.18 EDK38347.2 - 2e-23 81.5 0.0 2.3e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 EDK38347.2 - 1.2e-15 56.8 0.0 1.4e-15 56.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.3 EDK38347.2 - 0.0079 16.0 0.0 0.0089 15.9 0.0 1.2 1 0 0 1 1 1 1 GLUT4 regulating protein TUG DUF2407 PF10302.4 EDK38347.2 - 0.013 15.6 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 EDK38347.2 - 0.016 15.4 0.0 0.03 14.5 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain TPR_14 PF13428.1 EDK38348.2 - 6.4e-13 48.0 0.0 0.072 13.7 0.0 7.0 7 2 1 8 8 8 3 Tetratricopeptide repeat HAT PF02184.11 EDK38348.2 - 1.2e-09 37.7 31.9 0.019 14.6 0.2 10.4 10 0 0 10 10 10 4 HAT (Half-A-TPR) repeat Suf PF05843.9 EDK38348.2 - 8.1e-07 29.0 18.6 0.037 13.7 2.7 6.2 3 2 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_16 PF13432.1 EDK38348.2 - 3e-05 24.5 0.1 1.5 9.6 0.0 5.6 4 2 2 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 EDK38348.2 - 3.8e-05 23.1 2.1 0.99 9.3 0.0 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 EDK38348.2 - 0.0028 17.9 0.0 9.1 6.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38348.2 - 0.0048 16.7 2.2 19 5.3 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38348.2 - 0.013 15.4 4.0 6.6 6.9 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat U3_assoc_6 PF08640.6 EDK38348.2 - 0.019 14.6 1.0 0.019 14.6 0.7 5.1 6 1 1 7 7 7 0 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.1 EDK38348.2 - 0.032 14.6 3.2 31 5.3 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat PA PF02225.17 EDK38349.2 - 9.1e-07 28.5 0.0 2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M28 PF04389.12 EDK38349.2 - 8.5e-05 22.3 0.0 0.00023 20.9 0.0 1.7 1 0 0 1 1 1 1 Peptidase family M28 Rad21_Rec8_N PF04825.8 EDK38350.2 - 2.2e-11 43.6 0.1 4.4e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 EDK38350.2 - 0.056 12.6 0.0 0.73 9.0 0.0 2.4 2 0 0 2 2 2 0 Conserved region of Rad21 / Rec8 like protein Pil1 PF13805.1 EDK38351.1 - 1.3e-153 509.8 1.3 1.5e-153 509.6 0.9 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.5 EDK38351.1 - 0.026 14.3 2.6 0.62 9.9 0.1 3.2 3 0 0 3 3 3 0 Proto-chlorophyllide reductase 57 kD subunit Hat1_N PF10394.4 EDK38352.1 - 3.5e-37 127.9 1.1 6.5e-37 127.0 0.8 1.5 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_7 PF13508.1 EDK38352.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AHS2 PF02626.10 EDK38353.2 - 8.2e-82 274.5 0.0 1.5e-81 273.6 0.0 1.4 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 AHS1 PF02682.11 EDK38353.2 - 5e-48 163.2 0.0 7.7e-48 162.6 0.0 1.2 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 Biotin_lipoyl PF00364.17 EDK38353.2 - 8e-18 63.8 1.6 8e-18 63.8 1.1 3.1 4 0 0 4 4 4 1 Biotin-requiring enzyme RnfC_N PF13375.1 EDK38353.2 - 0.00083 19.0 0.1 0.0025 17.4 0.0 1.9 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD PF00529.15 EDK38353.2 - 0.35 10.1 1.5 1.6 7.9 0.2 2.2 2 0 0 2 2 2 0 HlyD family secretion protein Biotin_lipoyl_2 PF13533.1 EDK38353.2 - 3 7.5 10.1 4.1 7.1 0.1 3.7 3 1 1 4 4 4 0 Biotin-lipoyl like CPSase_L_D2 PF02786.12 EDK38354.2 - 2.2e-60 203.5 0.0 4.2e-60 202.6 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EDK38354.2 - 3.1e-39 133.4 0.0 1.1e-38 131.6 0.0 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EDK38354.2 - 4.8e-20 72.0 0.0 1.3e-19 70.6 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain Biotin_carb_C PF02785.14 EDK38354.2 - 1.3e-13 50.8 0.1 5.4e-13 48.8 0.0 2.1 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain ATPgrasp_Ter PF15632.1 EDK38354.2 - 1.5e-12 46.9 0.0 1.4e-07 30.5 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EDK38354.2 - 1e-10 41.3 0.0 2.2e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Amidase PF01425.16 EDK38354.2 - 1.8e-10 40.2 0.0 3.1e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Amidase ATP-grasp PF02222.17 EDK38354.2 - 1e-05 24.9 0.0 2.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EDK38354.2 - 0.00023 20.7 0.0 0.02 14.3 0.0 2.5 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EDK38354.2 - 0.0019 18.0 0.0 0.0053 16.6 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 EDK38354.2 - 0.0081 15.3 0.1 0.017 14.3 0.1 1.5 1 1 0 1 1 1 1 ATP-grasp domain Amidase PF01425.16 EDK38355.2 - 6.4e-73 246.0 0.0 7.9e-73 245.7 0.0 1.0 1 0 0 1 1 1 1 Amidase DUF1761 PF08570.5 EDK38356.1 - 0.0024 17.8 4.2 0.0029 17.6 2.1 1.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1761) DUF2207 PF09972.4 EDK38356.1 - 0.003 16.2 0.4 0.0036 15.9 0.3 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Sec62 PF03839.11 EDK38356.1 - 0.25 10.7 4.1 0.36 10.1 2.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Fijivirus_P9-2 PF06837.6 EDK38356.1 - 9 5.3 6.8 11 5.1 4.7 1.4 1 1 0 1 1 1 0 Fijivirus P9-2 protein SSF PF00474.12 EDK38357.2 - 1.6e-16 59.9 31.0 2.3e-16 59.4 21.5 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family EAP30 PF04157.11 EDK38358.2 - 2.4e-40 138.0 0.1 3.8e-40 137.4 0.1 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 EDK38358.2 - 2.4e-30 104.2 0.0 4.5e-30 103.2 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 EDK38358.2 - 0.00011 21.6 0.0 0.00025 20.5 0.0 1.6 1 0 0 1 1 1 1 GRAM domain zf-RanBP PF00641.13 EDK38358.2 - 0.012 14.6 2.2 0.012 14.6 1.5 2.7 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others DZR PF12773.2 EDK38358.2 - 0.029 14.1 7.9 0.033 13.9 1.5 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 EDK38358.2 - 5.8 6.2 10.2 6 6.2 2.6 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Mo25 PF08569.6 EDK38359.2 - 4.8e-125 417.0 5.6 5.4e-125 416.8 3.9 1.0 1 0 0 1 1 1 1 Mo25-like Aminotran_4 PF01063.14 EDK38360.2 - 4.5e-31 108.1 0.0 7.4e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class IV Glyco_hydro_47 PF01532.15 EDK38361.2 - 6.2e-131 437.1 0.1 8.5e-131 436.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF624 PF04854.9 EDK38361.2 - 0.12 12.2 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Phosphodiest PF01663.17 EDK38362.2 - 7.1e-14 51.9 0.1 1e-13 51.3 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EDK38362.2 - 2.2e-05 23.7 0.1 3.4e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 EDK38362.2 - 7.6e-05 22.2 0.1 0.00013 21.4 0.1 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily CTK3_C PF12350.3 EDK38363.2 - 0.21 11.6 1.7 12 6.0 0.2 2.6 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus Retrotrans_gag PF03732.12 EDK38363.2 - 0.3 11.1 2.1 0.76 9.8 1.4 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein FAM183 PF14886.1 EDK38363.2 - 7.9 7.0 8.1 2.3 8.8 1.6 2.2 2 0 0 2 2 2 0 FAM183A and FAM183B related Pkinase PF00069.20 EDK38364.2 - 2.5e-70 236.5 0.0 3.4e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38364.2 - 9.3e-31 106.8 0.0 1.4e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EDK38364.2 - 5.1e-12 46.1 1.1 5.1e-12 46.1 0.7 2.6 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EDK38364.2 - 3e-09 36.2 0.0 7.2e-09 35.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like C2 PF00168.25 EDK38364.2 - 1.1e-07 31.6 0.0 3e-06 26.9 0.0 2.7 1 1 0 1 1 1 1 C2 domain APH PF01636.18 EDK38364.2 - 0.031 13.9 0.1 0.06 13.0 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 EDK38364.2 - 0.064 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 EDK38364.2 - 0.081 11.9 0.1 0.21 10.6 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L28 PF00830.14 EDK38365.2 - 1.2e-14 53.8 2.4 2e-14 53.1 1.6 1.4 1 0 0 1 1 1 1 Ribosomal L28 family DsbC_N PF10411.4 EDK38365.2 - 0.0061 15.8 0.0 0.015 14.5 0.0 1.7 1 0 0 1 1 1 1 Disulfide bond isomerase protein N-terminus BORG_CEP PF14957.1 EDK38366.2 - 0.052 14.4 2.3 0.59 11.0 0.1 2.1 2 0 0 2 2 2 0 Cdc42 effector Myf5 PF12232.3 EDK38366.2 - 0.22 12.1 2.7 0.3 11.7 0.9 2.0 2 1 0 2 2 2 0 Myogenic determination factor 5 DUF1640 PF07798.6 EDK38367.2 - 9.5e-13 48.5 5.6 1.4e-12 48.0 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) AAA PF00004.24 EDK38368.2 - 2.8e-95 315.5 0.0 3.4e-47 159.9 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EDK38368.2 - 1.5e-15 56.8 0.0 7.5e-09 34.9 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EDK38368.2 - 1.3e-13 51.2 1.6 0.0021 18.2 0.0 6.0 3 2 1 4 4 3 2 AAA domain AAA_2 PF07724.9 EDK38368.2 - 2.5e-13 50.2 0.1 6.1e-05 23.0 0.0 3.4 3 1 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 EDK38368.2 - 2.4e-12 47.7 0.2 2.6e-07 31.4 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 EDK38368.2 - 3.8e-12 46.5 0.2 9.8e-05 22.4 0.1 3.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_14 PF13173.1 EDK38368.2 - 4.9e-11 42.6 0.0 9.2e-05 22.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 EDK38368.2 - 3.4e-10 39.3 0.0 0.00059 18.9 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_33 PF13671.1 EDK38368.2 - 4.2e-10 39.6 0.0 0.0013 18.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EDK38368.2 - 4.7e-10 39.3 0.4 0.00013 21.6 0.0 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EDK38368.2 - 1.8e-08 33.5 0.0 0.00068 18.4 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 EDK38368.2 - 3.4e-08 33.6 0.0 0.0016 18.5 0.0 2.7 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.22 EDK38368.2 - 4.8e-08 33.4 0.0 0.0079 16.4 0.0 3.4 2 1 0 2 2 2 2 ABC transporter AAA_19 PF13245.1 EDK38368.2 - 1.6e-07 31.0 0.1 0.0096 15.6 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 EDK38368.2 - 3.2e-07 29.9 4.3 0.13 11.6 0.0 4.5 2 2 2 4 4 4 1 AAA domain IstB_IS21 PF01695.12 EDK38368.2 - 3.3e-07 29.8 0.6 0.038 13.4 0.0 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_18 PF13238.1 EDK38368.2 - 4.1e-07 30.3 5.7 0.00024 21.4 0.0 4.4 5 0 0 5 5 3 2 AAA domain AAA_28 PF13521.1 EDK38368.2 - 4.2e-07 30.0 0.0 0.006 16.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 EDK38368.2 - 4.4e-07 29.2 0.4 0.02 14.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Cytidylate_kin2 PF13189.1 EDK38368.2 - 3.2e-06 27.1 0.3 0.0011 18.8 0.0 3.0 3 0 0 3 3 2 1 Cytidylate kinase-like family Arch_ATPase PF01637.13 EDK38368.2 - 6.6e-06 25.9 1.0 0.12 12.0 0.0 4.4 3 2 1 4 4 4 2 Archaeal ATPase Vps4_C PF09336.5 EDK38368.2 - 7.1e-06 25.8 0.1 0.001 18.8 0.0 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain SKI PF01202.17 EDK38368.2 - 7.6e-06 25.8 1.0 0.034 14.0 0.0 3.2 3 0 0 3 3 2 2 Shikimate kinase NACHT PF05729.7 EDK38368.2 - 9.2e-06 25.4 0.3 0.15 11.7 0.0 3.5 3 1 1 4 4 3 2 NACHT domain AAA_3 PF07726.6 EDK38368.2 - 1e-05 25.1 0.0 0.07 12.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 EDK38368.2 - 2e-05 24.3 1.4 0.36 10.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.17 EDK38368.2 - 2.6e-05 23.2 0.0 0.59 8.9 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain AAA_24 PF13479.1 EDK38368.2 - 6.1e-05 22.6 0.1 0.073 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 EDK38368.2 - 0.00011 21.3 0.2 2.2 7.3 0.0 3.6 2 1 1 3 3 3 1 KaiC DUF815 PF05673.8 EDK38368.2 - 0.00012 21.1 0.0 0.096 11.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.10 EDK38368.2 - 0.00015 20.6 0.0 0.056 12.1 0.0 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Viral_helicase1 PF01443.13 EDK38368.2 - 0.00017 21.1 0.6 0.57 9.6 0.0 3.4 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 EDK38368.2 - 0.00041 19.8 0.0 0.26 10.7 0.0 2.8 3 0 0 3 3 2 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EDK38368.2 - 0.00052 20.0 0.0 1.7 8.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EDK38368.2 - 0.00077 18.4 0.2 0.52 9.1 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 FeoB_N PF02421.13 EDK38368.2 - 0.0012 18.1 0.3 1.1 8.4 0.0 3.9 3 1 1 4 4 4 1 Ferrous iron transport protein B NTPase_1 PF03266.10 EDK38368.2 - 0.0018 18.0 0.0 1.1 8.9 0.0 2.8 2 0 0 2 2 2 1 NTPase ATP-synt_ab PF00006.20 EDK38368.2 - 0.0026 17.2 0.0 2.5 7.5 0.0 2.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.11 EDK38368.2 - 0.0044 16.2 0.5 1.1 8.5 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein CPT PF07931.7 EDK38368.2 - 0.0045 16.6 0.0 0.091 12.3 0.0 2.8 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.4 EDK38368.2 - 0.0067 15.9 0.0 2 7.9 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation KTI12 PF08433.5 EDK38368.2 - 0.016 14.4 0.3 1.1 8.4 0.0 3.1 3 0 0 3 3 3 0 Chromatin associated protein KTI12 UPF0079 PF02367.12 EDK38368.2 - 0.016 14.7 0.1 2 8.0 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 EDK38368.2 - 0.019 14.9 0.0 0.8 9.6 0.0 3.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF258 PF03193.11 EDK38368.2 - 0.023 13.8 0.0 0.42 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 EDK38368.2 - 0.023 14.1 0.9 6.2 6.1 0.0 3.6 3 1 0 3 3 3 0 AAA-like domain AAA_29 PF13555.1 EDK38368.2 - 0.033 13.7 0.0 0.6 9.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ADK PF00406.17 EDK38368.2 - 0.059 13.2 0.0 3 7.6 0.0 2.4 2 0 0 2 2 2 0 Adenylate kinase AAA_30 PF13604.1 EDK38368.2 - 0.074 12.6 0.0 12 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 EDK38368.2 - 0.21 11.8 0.0 0.21 11.8 0.0 3.8 3 1 1 4 4 2 0 AAA domain ResIII PF04851.10 EDK38368.2 - 8.9 6.0 8.2 15 5.3 0.0 3.8 3 1 1 4 4 3 0 Type III restriction enzyme, res subunit HSP9_HSP12 PF04119.7 EDK38369.1 - 5.1e-27 93.7 8.9 7.6e-27 93.1 3.7 2.2 2 1 0 2 2 2 1 Heat shock protein 9/12 Tape_meas_lam_C PF09718.5 EDK38369.1 - 0.014 15.2 7.4 0.17 11.8 0.2 2.6 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) SNARE PF05739.14 EDK38369.1 - 0.053 13.2 3.1 4.7 6.9 0.4 2.6 2 0 0 2 2 2 0 SNARE domain DUF883 PF05957.8 EDK38369.1 - 0.11 12.9 6.7 0.26 11.7 3.8 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2823 PF11034.3 EDK38369.1 - 0.18 11.9 15.2 0.2 11.7 0.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2823) Mt_ATP-synt_B PF05405.9 EDK38369.1 - 0.22 10.9 4.5 0.78 9.1 1.0 2.0 1 1 1 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4449 PF14613.1 EDK38369.1 - 0.48 10.3 5.6 0.71 9.7 3.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) MIT PF04212.13 EDK38369.1 - 0.81 9.6 5.9 3.7 7.4 0.0 2.4 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain ERp29 PF07749.7 EDK38369.1 - 0.84 10.3 6.4 0.28 11.8 1.8 1.9 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain MT0933_antitox PF14013.1 EDK38369.1 - 2 8.5 13.6 8.9 6.5 0.7 3.4 2 2 0 2 2 2 0 MT0933-like antitoxin protein MxiH PF09392.5 EDK38369.1 - 7.7 7.1 9.4 28 5.3 6.5 2.0 1 1 0 1 1 1 0 Type III secretion needle MxiH like RRM_1 PF00076.17 EDK38370.2 - 4.5e-08 32.5 1.2 3.9e-05 23.2 0.1 3.3 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK38370.2 - 5.4e-06 26.1 0.3 0.00026 20.7 0.2 2.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38370.2 - 5.3e-05 23.1 0.4 0.00046 20.1 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Dopey_N PF04118.9 EDK38372.2 - 1.2e-116 388.8 5.2 1.2e-115 385.5 1.1 2.7 2 0 0 2 2 2 2 Dopey, N-terminal Abhydrolase_2 PF02230.11 EDK38373.1 - 6.1e-49 166.3 0.0 7.1e-49 166.1 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 EDK38373.1 - 1.9e-09 37.4 0.0 2.3e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 EDK38373.1 - 2.3e-07 30.4 0.0 3.4e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.13 EDK38373.1 - 4e-06 26.2 0.1 5.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 EDK38373.1 - 5.4e-05 23.1 0.0 0.0038 17.1 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EDK38373.1 - 0.0011 18.2 0.1 0.1 11.8 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family LIP PF03583.9 EDK38373.1 - 0.0046 16.2 0.0 0.012 14.8 0.0 1.7 2 0 0 2 2 2 1 Secretory lipase BAAT_C PF08840.6 EDK38373.1 - 0.025 14.2 0.1 0.039 13.6 0.0 1.3 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Cutinase PF01083.17 EDK38373.1 - 0.035 13.8 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Cutinase Abhydrolase_3 PF07859.8 EDK38373.1 - 0.097 12.2 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PE-PPE PF08237.6 EDK38373.1 - 0.12 11.7 0.1 0.32 10.4 0.0 1.6 1 1 0 2 2 2 0 PE-PPE domain Dus PF01207.12 EDK38374.1 - 5.9e-77 258.5 0.0 8e-77 258.1 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-C2H2 PF00096.21 EDK38375.2 - 9.7e-08 31.9 11.2 0.0016 18.6 2.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK38375.2 - 2.6e-06 27.4 12.5 4.6e-06 26.6 2.5 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK38375.2 - 0.00036 20.6 12.9 0.0067 16.6 2.3 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger Cauli_AT PF03233.8 EDK38375.2 - 0.3 10.7 4.2 0.32 10.6 0.1 2.6 3 0 0 3 3 3 0 Aphid transmission protein Glyco_tran_28_C PF04101.11 EDK38376.2 - 4.6e-19 68.6 0.3 3.4e-18 65.8 0.2 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 EDK38376.2 - 0.00018 20.8 0.0 0.00025 20.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 1 DUF2369 PF10179.4 EDK38376.2 - 0.004 16.3 0.0 0.0051 15.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2369) THF_DHG_CYH_C PF02882.14 EDK38376.2 - 0.0076 15.3 0.8 0.031 13.3 0.1 2.2 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TFIID-18kDa PF02269.11 EDK38377.2 - 2e-18 65.9 0.0 3.1e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit DUF1931 PF09123.6 EDK38377.2 - 0.0047 16.8 0.0 0.0074 16.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1931) RINGv PF12906.2 EDK38378.2 - 2.3e-15 56.3 10.5 5.1e-15 55.2 7.3 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 EDK38378.2 - 0.011 15.5 8.2 0.022 14.5 5.7 1.6 1 0 0 1 1 1 0 Ring finger domain FANCL_C PF11793.3 EDK38378.2 - 0.38 10.7 5.0 1.1 9.2 3.4 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 EDK38378.2 - 0.45 10.2 5.8 0.86 9.3 4.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pribosyl_synth PF14572.1 EDK38379.2 - 5.4e-42 143.6 3.0 1.4e-35 122.7 1.4 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 EDK38379.2 - 7.7e-38 128.8 0.7 4.4e-37 126.3 0.0 2.3 2 1 1 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EDK38379.2 - 3.9e-12 45.9 1.2 2.6e-11 43.3 0.9 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EDK38379.2 - 0.02 14.0 0.2 0.037 13.2 0.1 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase TAFII55_N PF04658.8 EDK38380.2 - 6.5e-45 152.5 0.0 6.5e-45 152.5 0.0 2.2 3 1 0 3 3 3 1 TAFII55 protein conserved region DUF506 PF04720.7 EDK38380.2 - 4.3 6.9 13.8 2.1 7.9 8.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF506) Gcd10p PF04189.8 EDK38380.2 - 7.6 5.5 12.6 9.7 5.2 8.2 1.6 1 1 0 1 1 1 0 Gcd10p family P5-ATPase PF12409.3 EDK38381.2 - 2.1e-38 130.8 0.0 7.3e-38 129.0 0.0 2.0 1 0 0 1 1 1 1 P5-type ATPase cation transporter HAD PF12710.2 EDK38381.2 - 6.4e-30 104.7 0.0 1.2e-29 103.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EDK38381.2 - 1.6e-29 102.5 0.1 3.7e-29 101.3 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EDK38381.2 - 7.2e-19 69.0 0.0 1.4e-17 64.7 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK38381.2 - 4.8e-07 29.6 0.0 1.3e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 EDK38381.2 - 0.00012 21.4 0.0 0.00034 20.0 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EDK38381.2 - 0.0036 16.9 0.7 0.4 10.2 0.0 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Grp1_Fun34_YaaH PF01184.14 EDK38382.1 - 2.2e-92 308.1 23.1 2.5e-92 307.9 16.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF202 PF02656.10 EDK38383.1 - 8.6e-14 51.5 4.3 8.6e-14 51.5 3.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) LHC PF00556.15 EDK38383.1 - 0.19 11.6 0.2 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit MARVEL PF01284.18 EDK38383.1 - 0.19 11.5 4.3 0.26 11.0 3.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain DUF2207 PF09972.4 EDK38383.1 - 0.41 9.1 3.3 0.44 9.0 2.3 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2347 PF09804.4 EDK38384.2 - 8.9e-76 254.8 1.2 8.9e-76 254.8 0.9 1.8 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 EDK38384.2 - 3.3e-34 118.5 6.2 4.9e-33 114.7 4.3 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) Avl9 PF09794.4 EDK38384.2 - 3.4e-09 35.6 0.2 9.2e-09 34.2 0.2 1.7 1 1 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 EDK38384.2 - 0.002 17.7 0.1 0.0045 16.6 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Aldo_ket_red PF00248.16 EDK38385.2 - 5.6e-62 209.1 0.0 6.7e-62 208.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Homeobox PF00046.24 EDK38386.2 - 2.2e-18 65.6 1.1 3.9e-18 64.8 0.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 EDK38386.2 - 0.00055 19.5 0.7 0.0012 18.4 0.5 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 EDK38386.2 - 0.016 14.2 0.0 0.034 13.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez DUF4518 PF15008.1 EDK38386.2 - 0.056 12.4 0.3 0.11 11.5 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) TPR_11 PF13414.1 EDK38387.2 - 0.0013 18.3 0.5 0.0029 17.2 0.0 1.9 2 0 0 2 2 2 1 TPR repeat Sel1 PF08238.7 EDK38387.2 - 0.0025 18.4 0.4 1.9 9.2 0.0 3.9 4 0 0 4 4 4 1 Sel1 repeat Pkinase PF00069.20 EDK38388.2 - 3.9e-56 190.0 0.0 4.8e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38388.2 - 4.1e-24 85.0 0.0 4.9e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38388.2 - 0.03 13.2 0.0 3.3 6.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.9 EDK38388.2 - 0.072 12.1 0.0 0.099 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 EDK38388.2 - 0.098 11.4 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RINT1_TIP1 PF04437.8 EDK38389.2 - 4.7e-59 200.2 17.5 4.7e-59 200.2 12.1 1.9 2 0 0 2 2 2 1 RINT-1 / TIP-1 family Cpn60_TCP1 PF00118.19 EDK38390.2 - 1.1e-156 522.3 2.2 1.2e-156 522.1 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SH3_1 PF00018.23 EDK38391.2 - 7.4e-08 31.6 0.4 1.6e-07 30.5 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK38391.2 - 3.6e-06 26.4 0.7 7.5e-06 25.4 0.5 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK38391.2 - 3.2e-05 23.3 0.2 7.4e-05 22.1 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.20 EDK38392.2 - 7.2e-68 228.5 0.0 8.9e-68 228.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38392.2 - 7.7e-31 107.0 0.0 9.9e-31 106.7 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38392.2 - 0.0003 19.8 0.0 0.00044 19.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK38392.2 - 0.0056 16.4 0.1 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 EDK38392.2 - 0.085 11.6 0.1 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DAO PF01266.19 EDK38393.2 - 6.1e-50 170.1 0.0 6.8e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 EDK38393.2 - 0.0015 18.6 0.3 0.055 13.5 0.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK38393.2 - 0.0025 17.7 0.2 0.0063 16.5 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.10 EDK38393.2 - 0.082 11.0 0.0 1.1 7.3 0.1 2.3 3 0 0 3 3 3 0 Malate:quinone oxidoreductase (Mqo) VTC PF09359.5 EDK38394.1 - 3.1e-104 347.9 0.5 4.7e-104 347.3 0.0 1.5 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 EDK38394.1 - 9.3e-22 78.0 18.5 1.2e-10 41.5 0.2 3.6 2 1 1 3 3 3 2 SPX domain DUF202 PF02656.10 EDK38394.1 - 3.7e-11 43.0 6.5 3.7e-11 43.0 4.5 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF202) Herpes_UL25 PF01499.11 EDK38394.1 - 0.027 12.7 0.2 0.042 12.1 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family LXG PF04740.7 EDK38394.1 - 0.65 9.7 8.6 1.2 8.8 0.3 3.0 2 1 1 3 3 3 0 LXG domain of WXG superfamily DAO PF01266.19 EDK38395.2 - 9e-22 77.4 0.0 2.2e-21 76.1 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EDK38395.2 - 0.013 14.1 0.0 0.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.22 EDK38395.2 - 0.016 15.5 0.0 0.045 14.1 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EDK38395.2 - 0.046 12.8 0.1 0.44 9.6 0.0 2.1 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.1 EDK38395.2 - 0.064 13.2 0.2 0.17 11.9 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 EDK38395.2 - 0.16 11.7 0.3 0.84 9.3 0.2 2.1 2 1 0 2 2 2 0 FAD-NAD(P)-binding Hydrolase PF00702.21 EDK38396.2 - 6.9e-19 69.1 0.0 1.2e-14 55.2 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EDK38396.2 - 1.8e-17 63.1 1.1 5.2e-17 61.6 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 EDK38396.2 - 1.7e-14 54.4 1.5 1.6e-13 51.2 1.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK38396.2 - 3.6e-11 42.8 0.0 1.3e-10 41.0 0.0 2.1 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EDK38396.2 - 0.003 17.1 0.1 0.003 17.1 0.1 3.5 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase Pyr_redox_2 PF07992.9 EDK38397.2 - 1.4e-10 41.4 0.0 3e-10 40.3 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK38397.2 - 5.5e-08 33.0 0.6 1.9e-05 24.9 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK38397.2 - 4.4e-07 30.1 0.1 6.8e-06 26.2 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK38397.2 - 1.6e-06 27.2 0.2 7.6e-05 21.7 0.0 1.9 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EDK38397.2 - 0.00036 20.3 0.1 0.031 14.0 0.0 3.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding Ldh_1_N PF00056.18 EDK38397.2 - 0.11 12.2 0.1 22 4.8 0.0 2.4 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DUF3336 PF11815.3 EDK38399.2 - 1.3e-36 125.2 2.5 2.5e-36 124.3 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EDK38399.2 - 1.7e-07 31.3 0.0 5e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 Patatin-like phospholipase Erf4 PF10256.4 EDK38399.2 - 0.023 14.5 0.3 0.19 11.5 0.0 2.5 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family DUF2348 PF09807.4 EDK38400.2 - 0.00067 18.8 0.0 0.0011 18.1 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2348) Leu_zip PF15294.1 EDK38400.2 - 0.098 11.7 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Leucine zipper Mito_carr PF00153.22 EDK38401.2 - 6.9e-64 211.5 1.4 2.1e-22 78.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M22 PF00814.20 EDK38402.2 - 2e-55 188.1 0.0 2.9e-55 187.6 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.15 EDK38402.2 - 0.019 14.2 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Nse4_C PF08743.5 EDK38403.2 - 2.5e-19 69.0 0.1 6.3e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 EDK38403.2 - 1.4e-09 37.5 0.8 2.8e-09 36.6 0.1 1.8 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE DNA_mis_repair PF01119.14 EDK38404.2 - 2.8e-33 113.8 0.1 5.3e-33 113.0 0.1 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 EDK38404.2 - 8.8e-15 54.5 0.0 2e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EDK38404.2 - 7.7e-10 38.4 0.2 2.8e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_14 PF13428.1 EDK38405.2 - 1.9e-08 34.2 1.0 0.00062 20.1 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 EDK38405.2 - 2e-07 31.2 1.3 0.044 14.1 0.0 4.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38405.2 - 0.0019 18.8 0.7 2.3 8.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 EDK38405.2 - 0.0059 16.7 1.2 2.8 8.3 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EDK38405.2 - 0.044 13.6 0.0 1.2 9.1 0.0 3.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.12 EDK38405.2 - 0.67 10.0 9.5 5.4 7.1 0.1 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.23 EDK38405.2 - 6.4 6.5 10.4 1.8 8.2 0.2 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat SUI1 PF01253.17 EDK38406.1 - 3.7e-20 71.5 2.8 3.7e-20 71.5 1.9 2.3 2 0 0 2 2 2 1 Translation initiation factor SUI1 MoCF_biosynth PF00994.19 EDK38406.1 - 0.048 13.0 1.7 0.14 11.5 0.3 2.1 1 1 2 3 3 3 0 Probable molybdopterin binding domain FAM110_C PF14160.1 EDK38406.1 - 0.059 14.3 2.7 1.3 10.0 0.4 2.3 2 1 0 2 2 2 0 Centrosome-associated C terminus DUF4157 PF13699.1 EDK38406.1 - 0.072 13.2 0.2 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) DUF3759 PF12585.3 EDK38406.1 - 0.27 11.1 9.1 0.82 9.6 0.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3759) PIN_2 PF10130.4 EDK38406.1 - 0.28 11.2 7.0 0.84 9.6 4.1 2.1 1 1 1 2 2 2 0 PIN domain TnpV PF14198.1 EDK38406.1 - 0.43 10.4 8.9 0.053 13.4 2.2 2.0 2 0 0 2 2 2 0 Transposon-encoded protein TnpV zf-DNA_Pol PF08996.5 EDK38406.1 - 1.1 8.5 6.7 1.5 8.1 1.3 2.1 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Cgr1 PF03879.9 EDK38406.1 - 1.3 9.2 20.5 0.16 12.1 8.3 2.3 2 0 0 2 2 2 0 Cgr1 family Coq4 PF05019.8 EDK38407.2 - 0.069 12.0 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Zn_clus PF00172.13 EDK38408.2 - 1.8e-08 34.1 6.4 2.9e-08 33.5 4.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Arch_ATPase PF01637.13 EDK38409.2 - 6e-06 26.1 0.1 6e-06 26.1 0.1 3.3 4 1 0 4 4 4 1 Archaeal ATPase AAA_16 PF13191.1 EDK38409.2 - 0.00014 21.8 0.1 0.0069 16.3 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EDK38409.2 - 0.0027 17.8 0.0 0.0084 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EDK38409.2 - 0.025 14.7 0.0 0.075 13.2 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EDK38409.2 - 0.029 13.7 0.0 0.085 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 EDK38409.2 - 0.053 13.2 0.0 0.82 9.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sensor PF13796.1 EDK38409.2 - 0.39 10.3 0.0 0.63 9.6 0.0 1.2 1 0 0 1 1 1 0 Putative sensor HECT PF00632.20 EDK38410.2 - 1.3e-84 284.0 3.8 1.6e-84 283.8 1.0 2.3 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Fungal_trans PF04082.13 EDK38411.2 - 4.4e-14 51.9 1.1 8.1e-14 51.1 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38411.2 - 1e-08 34.9 10.1 1.7e-08 34.2 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase_6 PF13344.1 EDK38412.2 - 5.5e-25 87.1 0.0 9.9e-25 86.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK38412.2 - 4.7e-09 36.9 0.0 2.1e-08 34.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EDK38412.2 - 1.5e-07 30.9 0.0 4e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 EDK38412.2 - 0.001 19.3 0.3 0.77 9.9 0.1 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Rpp20 PF12328.3 EDK38414.2 - 2.1e-30 105.2 0.7 2.7e-30 104.9 0.5 1.1 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 EDK38414.2 - 3.7e-18 64.8 0.6 6.2e-18 64.1 0.4 1.4 1 0 0 1 1 1 1 Alba Pam16 PF03656.8 EDK38415.2 - 1e-07 31.7 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.26 EDK38415.2 - 3.8e-07 29.7 0.0 6.1e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L24e PF01246.15 EDK38416.1 - 7.7e-28 96.1 1.2 2.8e-27 94.3 0.8 2.0 1 0 0 1 1 1 1 Ribosomal protein L24e SEEEED PF14797.1 EDK38416.1 - 0.0018 18.4 8.9 0.0026 17.9 6.2 1.3 1 0 0 1 1 1 1 Serine-rich region of AP3B1, clathrin-adaptor complex ANTH PF07651.11 EDK38417.2 - 2.5e-62 210.1 3.5 2.5e-62 210.1 2.4 2.1 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.15 EDK38417.2 - 1.2e-07 31.6 1.9 2.5e-07 30.6 0.3 2.3 2 0 0 2 2 2 1 ENTH domain Glyco_hydro_16 PF00722.16 EDK38418.2 - 6.8e-49 165.6 2.9 6.8e-49 165.6 2.0 1.8 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 Rhodanese PF00581.15 EDK38419.1 - 6.6e-16 58.6 0.0 8.1e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.15 EDK38419.1 - 0.041 13.4 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain CTP_transf_2 PF01467.21 EDK38420.2 - 2.1e-25 89.5 0.0 3.6e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase DUF3360 PF11840.3 EDK38420.2 - 0.13 10.5 0.2 0.19 10.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3360) DUF2404 PF10296.4 EDK38421.2 - 4.8e-09 36.2 0.0 8.9e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Flo11 PF10182.4 EDK38422.1 - 8.6e-39 132.5 0.1 1.9e-38 131.4 0.1 1.5 1 0 0 1 1 1 1 Flo11 domain Flocculin_t3 PF13928.1 EDK38422.1 - 2.9e-16 59.3 20.2 2.9e-16 59.3 14.0 3.8 4 1 0 4 4 4 1 Flocculin type 3 repeat Flocculin_t3 PF13928.1 EDK38423.1 - 5.8e-12 45.5 64.6 5.6e-08 32.8 14.9 11.5 3 2 3 6 6 6 3 Flocculin type 3 repeat Adaptin_N PF01602.15 EDK38424.2 - 3.6e-86 289.5 12.3 4.4e-86 289.2 8.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 EDK38424.2 - 6.6e-11 42.3 2.5 0.00035 20.8 0.2 4.5 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.17 EDK38424.2 - 2.7e-09 36.3 0.6 0.19 11.8 0.0 5.4 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 EDK38424.2 - 4.6e-05 23.7 1.0 0.062 13.8 0.0 3.9 3 1 0 3 3 3 2 HEAT-like repeat TilS PF09179.6 EDK38424.2 - 0.21 11.6 1.7 0.52 10.3 0.3 2.3 2 0 0 2 2 2 0 TilS substrate binding domain Arm PF00514.18 EDK38424.2 - 0.22 11.4 4.8 17 5.3 0.0 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat XPG_N PF00752.12 EDK38425.2 - 8.8e-35 119.0 0.0 2.5e-34 117.5 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 EDK38425.2 - 1.1e-27 95.8 0.0 3.6e-27 94.2 0.0 1.9 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 EDK38425.2 - 0.00068 19.8 0.0 0.0033 17.6 0.0 2.2 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.11 EDK38425.2 - 0.023 14.7 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Y_phosphatase2 PF03162.8 EDK38426.1 - 2.6e-43 147.2 0.3 4.7e-40 136.6 0.2 2.1 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 EDK38426.1 - 3.8e-07 30.5 0.1 8.3e-07 29.3 0.0 1.5 2 0 0 2 2 2 1 Tyrosine phosphatase family Merozoite_SPAM PF07133.6 EDK38426.1 - 0.03 14.2 5.7 0.056 13.3 3.9 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) MAS20 PF02064.10 EDK38426.1 - 0.11 12.4 1.3 0.19 11.6 0.9 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor Lactamase_B PF00753.22 EDK38427.2 - 8.7e-29 100.5 0.3 1.1e-28 100.2 0.2 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 EDK38427.2 - 8.2e-05 22.2 0.7 0.0003 20.4 0.5 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain SGS PF05002.10 EDK38428.2 - 6.9e-27 93.0 3.1 6.9e-27 93.0 2.2 2.2 3 0 0 3 3 3 1 SGS domain CS PF04969.11 EDK38428.2 - 6e-18 65.1 0.2 6e-18 65.1 0.1 2.0 2 0 0 2 2 2 1 CS domain TPR_12 PF13424.1 EDK38428.2 - 6.2e-10 38.8 0.1 1.1e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38428.2 - 8.4e-10 37.8 0.9 0.0006 19.5 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK38428.2 - 1e-09 37.9 0.3 1.7e-09 37.1 0.2 1.3 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 EDK38428.2 - 8.2e-09 34.7 1.2 6.5e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK38428.2 - 3.4e-06 26.4 1.1 0.0023 17.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38428.2 - 0.0003 21.3 0.1 0.00076 20.0 0.0 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK38428.2 - 0.00082 19.6 0.4 1.5 9.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 EDK38428.2 - 0.0011 18.8 0.0 0.063 13.1 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 EDK38428.2 - 0.002 18.1 0.1 0.0085 16.2 0.1 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.1 EDK38428.2 - 0.0037 16.4 0.1 0.0064 15.6 0.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_3 PF07720.7 EDK38428.2 - 0.0048 16.6 1.4 0.76 9.6 0.1 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.4 EDK38428.2 - 0.0086 14.6 0.1 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_14 PF13428.1 EDK38428.2 - 0.038 14.6 0.0 0.48 11.1 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Pex14_N PF04695.8 EDK38428.2 - 3 7.8 8.5 0.44 10.5 2.0 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Kinesin PF00225.18 EDK38429.2 - 5.2e-105 350.8 2.4 5.2e-105 350.8 1.7 2.2 2 0 0 2 2 2 1 Kinesin motor domain ADIP PF11559.3 EDK38429.2 - 0.0014 18.4 12.4 0.0014 18.4 8.6 4.6 3 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding HrpB7 PF09486.5 EDK38429.2 - 0.0057 16.6 6.4 0.0057 16.6 4.4 2.8 1 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) AAA_10 PF12846.2 EDK38429.2 - 0.015 14.7 0.0 0.015 14.7 0.0 2.6 2 2 0 2 2 2 0 AAA-like domain TMF_TATA_bd PF12325.3 EDK38429.2 - 0.02 14.6 39.2 0.032 13.9 6.6 3.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding ImmE5 PF11480.3 EDK38429.2 - 0.13 12.1 0.4 4.4 7.1 0.0 2.9 2 1 1 3 3 3 0 Colicin-E5 Imm protein APG6 PF04111.7 EDK38429.2 - 0.34 9.9 46.1 0.1 11.6 9.4 3.6 1 1 2 3 3 3 0 Autophagy protein Apg6 Rrp15p PF07890.7 EDK38430.1 - 2.4e-32 111.6 11.9 2.4e-32 111.6 8.3 2.6 2 1 0 2 2 2 1 Rrp15p Daxx PF03344.10 EDK38430.1 - 0.0017 16.9 22.9 0.0019 16.7 15.9 1.0 1 0 0 1 1 1 1 Daxx Family RRS1 PF04939.7 EDK38430.1 - 0.045 13.2 0.1 0.045 13.2 0.1 2.8 1 1 1 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) NESP55 PF06390.7 EDK38430.1 - 2 7.7 18.6 2.3 7.5 12.1 1.6 1 1 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.6 EDK38430.1 - 3.9 7.3 13.9 6.3 6.6 9.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2890 PF11081.3 EDK38430.1 - 7.2 6.6 19.7 10 6.0 13.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DUF1639 PF07797.9 EDK38430.1 - 9.6 5.6 7.7 0.82 9.1 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1639) Hid1 PF12722.2 EDK38430.1 - 9.7 3.7 12.4 10 3.6 8.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPR PF01535.15 EDK38431.2 - 3.9e-07 29.6 0.2 0.027 14.4 0.0 4.2 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.1 EDK38431.2 - 9.7e-06 25.4 0.6 0.38 10.7 0.0 4.5 5 0 0 5 5 5 2 PPR repeat family PPR_3 PF13812.1 EDK38431.2 - 4.3e-05 23.4 0.0 3.2 8.2 0.0 4.7 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 EDK38431.2 - 0.05 13.0 0.3 0.05 13.0 0.2 2.8 4 0 0 4 4 4 0 PPR repeat Acyltransferase PF01553.16 EDK38432.2 - 2.2e-10 40.1 0.0 3.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Pescadillo_N PF06732.6 EDK38433.2 - 1.8e-121 404.7 1.9 1.8e-121 404.7 1.3 2.4 2 1 1 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 EDK38433.2 - 3.7e-09 36.6 0.0 1.3e-08 34.8 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DUF3371 PF11851.3 EDK38433.2 - 0.039 14.6 5.9 0.11 13.1 4.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Med18 PF09637.5 EDK38435.2 - 1.2e-101 339.5 2.3 1.3e-101 339.3 1.6 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.5 EDK38436.1 - 1.2e-14 53.9 9.5 1.7e-14 53.4 6.6 1.3 1 0 0 1 1 1 1 VMA21-like domain RseC_MucC PF04246.7 EDK38436.1 - 0.18 11.4 1.1 0.18 11.3 0.7 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF1385 PF07136.6 EDK38436.1 - 1.2 8.2 4.0 1.2 8.1 2.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) DUF1469 PF07332.6 EDK38436.1 - 8.5 6.1 7.7 12 5.6 5.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1469) ATP-synt_S1 PF05827.7 EDK38437.2 - 8e-38 130.3 1.1 1.1e-37 129.8 0.8 1.2 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) ERG4_ERG24 PF01222.12 EDK38438.2 - 7.2e-153 509.1 12.2 8.1e-153 508.9 8.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EDK38438.2 - 3.7e-06 26.4 1.5 3.7e-06 26.4 1.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Sporozoite_P67 PF05642.6 EDK38440.2 - 0.011 13.5 0.8 0.014 13.2 0.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_L3 PF00297.17 EDK38441.1 - 1e-119 398.7 9.6 1.2e-119 398.5 6.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 FadA PF09403.5 EDK38441.1 - 0.21 11.6 2.4 0.2 11.6 0.6 1.6 2 0 0 2 2 2 0 Adhesion protein FadA Ldh_1_C PF02866.13 EDK38442.1 - 2.8e-42 144.4 0.1 3.9e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 EDK38442.1 - 3.1e-42 143.7 0.1 4.7e-42 143.1 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.11 EDK38442.1 - 0.0048 16.2 0.0 0.096 11.9 0.0 2.4 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase 3Beta_HSD PF01073.14 EDK38442.1 - 0.049 12.3 0.0 0.076 11.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 EDK38442.1 - 0.1 12.4 0.0 0.31 10.9 0.0 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus CRM1_C PF08767.6 EDK38443.2 - 8e-121 402.8 4.2 8e-121 402.8 2.9 2.9 2 1 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.7 EDK38443.2 - 2.6e-39 134.4 4.7 2.6e-39 134.4 3.3 4.6 6 0 0 6 6 6 1 Exportin 1-like protein IBN_N PF03810.14 EDK38443.2 - 5.1e-16 58.3 0.9 5.1e-16 58.3 0.6 3.5 4 0 0 4 4 4 1 Importin-beta N-terminal domain V-ATPase_H_C PF11698.3 EDK38443.2 - 0.023 14.5 6.6 3.6 7.5 0.1 4.2 4 0 0 4 4 4 0 V-ATPase subunit H bPH_4 PF06713.6 EDK38443.2 - 0.13 12.1 2.3 5.5 6.9 0.0 3.4 3 0 0 3 3 3 0 Bacterial PH domain Ran_BP1 PF00638.13 EDK38444.1 - 1.2e-53 180.3 2.2 1.7e-53 179.8 1.5 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 EDK38444.1 - 1.7e-05 24.5 0.3 0.00021 20.9 0.2 2.2 1 1 0 1 1 1 1 WH1 domain Cellulose_synt PF03552.9 EDK38444.1 - 0.029 12.6 0.9 0.039 12.2 0.6 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF1681 PF07933.9 EDK38444.1 - 0.055 13.0 0.1 0.055 13.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1681) CDC27 PF09507.5 EDK38444.1 - 0.22 10.7 14.0 0.29 10.2 9.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM176 PF14851.1 EDK38444.1 - 2.1 8.0 4.7 4 7.1 3.3 1.5 1 0 0 1 1 1 0 FAM176 family Ank_2 PF12796.2 EDK38445.2 - 8.7e-41 138.1 9.9 8.4e-14 51.6 0.0 4.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK38445.2 - 3.4e-25 87.9 2.5 2.7e-07 30.9 0.0 5.2 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 EDK38445.2 - 1.1e-24 84.9 4.2 4.8e-07 29.2 0.0 6.6 6 0 0 6 6 6 6 Ankyrin repeat SPX PF03105.14 EDK38445.2 - 4.7e-24 85.6 21.8 2.5e-15 56.9 1.8 3.0 3 1 1 4 4 4 2 SPX domain Ank_3 PF13606.1 EDK38445.2 - 5.3e-24 81.9 5.8 0.00021 21.2 0.0 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.1 EDK38445.2 - 6.4e-20 70.7 7.0 0.0015 18.6 0.0 6.1 3 1 3 6 6 6 5 Ankyrin repeats (many copies) GDPD PF03009.12 EDK38445.2 - 9.1e-06 25.3 0.0 2.5e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family IgG_binding_B PF01378.12 EDK38445.2 - 0.15 11.9 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 B domain DUF2013 PF09431.5 EDK38446.2 - 3.5e-45 153.2 13.3 3.5e-45 153.2 9.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Ribosomal_L4 PF00573.17 EDK38447.1 - 2.6e-45 154.1 2.6 4.1e-45 153.5 1.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 EDK38447.1 - 1e-29 102.2 5.4 2e-29 101.2 2.5 2.2 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ras PF00071.17 EDK38448.1 - 6.7e-54 181.6 0.1 7.8e-54 181.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK38448.1 - 1.2e-20 74.2 0.0 1.7e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK38448.1 - 7.6e-17 61.0 0.0 9e-17 60.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK38448.1 - 1.5e-09 37.4 0.0 1.7e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EDK38448.1 - 2.1e-05 24.4 0.0 2.8e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK38448.1 - 9.9e-05 21.8 0.0 0.00018 20.9 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 EDK38448.1 - 0.038 13.9 0.1 0.074 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 EDK38448.1 - 0.04 13.0 0.1 0.06 12.5 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 G-alpha PF00503.15 EDK38448.1 - 0.13 10.8 0.0 3.5 6.2 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit Cpn10 PF00166.16 EDK38449.1 - 1.5e-27 95.3 0.0 1.7e-27 95.1 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit BP28CT PF08146.7 EDK38450.2 - 7.8e-45 152.3 5.3 2.2e-43 147.6 1.8 3.9 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 EDK38450.2 - 1.7e-17 63.5 0.2 1.6e-16 60.3 0.1 3.0 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.1 EDK38450.2 - 0.00057 20.1 0.5 5.6 7.3 0.0 4.0 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 EDK38450.2 - 0.00066 20.0 0.8 3.4 8.2 0.0 4.5 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.17 EDK38450.2 - 0.11 12.6 1.5 41 4.6 0.1 4.3 3 0 0 3 3 3 0 HEAT repeat AA_permease PF00324.16 EDK38451.2 - 1.1e-121 406.5 50.0 1.4e-121 406.2 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK38451.2 - 6.3e-28 97.4 52.5 8.4e-28 97.0 36.4 1.1 1 0 0 1 1 1 1 Amino acid permease Delta_lysin PF05372.6 EDK38451.2 - 3.1 7.2 6.1 1.3 8.4 0.6 2.4 2 0 0 2 2 2 0 Delta lysin family CAP PF00188.21 EDK38452.2 - 1.5e-18 67.4 7.1 2.3e-18 66.8 4.9 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF605 PF04652.11 EDK38452.2 - 3.1 7.0 32.2 4.2 6.6 22.3 1.2 1 0 0 1 1 1 0 Vta1 like DUF3808 PF10300.4 EDK38453.2 - 1.1e-116 390.2 0.1 1.5e-116 389.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.1 EDK38453.2 - 0.0098 16.5 2.0 0.74 10.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_5 PF12688.2 EDK38453.2 - 0.074 13.0 0.1 9.3 6.3 0.0 3.2 3 0 0 3 3 3 0 Tetratrico peptide repeat TPR_4 PF07721.9 EDK38453.2 - 0.11 12.9 2.8 4.6 7.9 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38453.2 - 0.54 10.3 4.0 8.6 6.5 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 EDK38453.2 - 0.94 9.8 5.1 1 9.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat UNC-50 PF05216.8 EDK38454.2 - 5.6e-91 303.8 13.9 6.5e-91 303.6 9.6 1.0 1 0 0 1 1 1 1 UNC-50 family DUF1509 PF07420.6 EDK38455.2 - 5.2 6.2 10.4 1.3 8.2 3.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1509) IBR PF01485.16 EDK38456.2 - 1.1e-16 60.4 30.3 1.4e-09 37.7 9.5 4.8 4 1 1 5 5 5 2 IBR domain zf-RING_2 PF13639.1 EDK38456.2 - 0.00067 19.4 10.0 0.00067 19.4 6.9 4.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK38456.2 - 0.0026 17.7 11.6 0.0026 17.7 8.0 4.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK38456.2 - 0.0098 15.5 10.2 0.0098 15.5 7.1 5.5 3 3 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Nop14 PF04147.7 EDK38457.2 - 1.3 6.8 20.4 2.4 5.9 14.1 1.3 1 0 0 1 1 1 0 Nop14-like family Pam16 PF03656.8 EDK38458.1 - 1e-33 115.8 0.2 1.3e-33 115.5 0.1 1.0 1 0 0 1 1 1 1 Pam16 UPF0128 PF03673.8 EDK38458.1 - 0.026 13.8 0.3 0.032 13.5 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) PHD PF00628.24 EDK38459.2 - 2.1e-07 30.5 10.5 4e-07 29.6 7.3 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 EDK38459.2 - 4.8e-06 26.9 7.8 5.4e-06 26.8 0.1 3.7 3 1 0 3 3 3 1 SET domain LRR_8 PF13855.1 EDK38460.2 - 1.6e-09 37.3 15.2 1.2e-05 24.9 0.8 3.6 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.2 EDK38460.2 - 5.3e-08 32.3 16.6 9.7e-06 25.0 1.9 4.8 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK38460.2 - 1.6e-06 27.3 15.5 0.56 10.4 0.0 6.7 4 1 2 6 6 6 3 Leucine Rich Repeat LRR_7 PF13504.1 EDK38460.2 - 0.0016 18.2 15.3 1.2 9.6 0.0 6.6 7 1 0 7 7 7 2 Leucine rich repeat LRR_6 PF13516.1 EDK38460.2 - 0.0091 15.9 19.3 2.7 8.3 0.1 6.7 3 2 3 6 6 6 2 Leucine Rich repeat FNIP PF05725.7 EDK38460.2 - 0.39 10.7 6.6 3.5 7.6 0.5 3.0 1 1 2 3 3 3 0 FNIP Repeat F-box PF00646.28 EDK38460.2 - 1.6 8.5 5.0 0.68 9.6 0.2 3.0 3 0 0 3 3 3 0 F-box domain ABC_membrane PF00664.18 EDK38461.2 - 9.2e-54 182.7 47.7 3e-30 105.5 16.3 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK38461.2 - 2.3e-49 167.2 0.6 3.5e-29 101.8 0.0 3.1 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EDK38461.2 - 3.2e-07 29.8 8.0 0.0067 15.6 0.3 4.4 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK38461.2 - 3.8e-07 29.5 0.7 0.0077 15.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 EDK38461.2 - 1e-06 28.9 21.9 1.8e-06 28.1 0.1 5.7 5 2 1 6 6 5 2 AAA domain AAA_17 PF13207.1 EDK38461.2 - 3.2e-05 24.7 2.4 0.31 11.8 0.0 3.4 3 0 0 3 3 2 2 AAA domain Miro PF08477.8 EDK38461.2 - 0.00012 22.5 0.5 0.79 10.2 0.1 2.9 2 0 0 2 2 2 2 Miro-like protein AAA_16 PF13191.1 EDK38461.2 - 0.0005 20.1 0.8 0.088 12.7 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 EDK38461.2 - 0.00071 19.5 2.5 0.54 10.2 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 EDK38461.2 - 0.0011 18.2 1.6 0.57 9.3 0.4 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_30 PF13604.1 EDK38461.2 - 0.0027 17.3 1.4 0.73 9.3 0.1 3.0 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 EDK38461.2 - 0.0068 15.8 0.0 0.3 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EDK38461.2 - 0.0098 14.9 2.7 1.5 7.8 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin ArgK PF03308.11 EDK38461.2 - 0.027 13.2 0.5 3.6 6.2 0.1 2.3 2 0 0 2 2 2 0 ArgK protein FtsK_SpoIIIE PF01580.13 EDK38461.2 - 0.034 13.6 3.5 0.28 10.6 0.0 2.9 4 0 0 4 4 3 0 FtsK/SpoIIIE family AAA_22 PF13401.1 EDK38461.2 - 0.038 14.1 1.9 12 5.9 0.2 3.3 3 0 0 3 3 3 0 AAA domain T2SE PF00437.15 EDK38461.2 - 0.046 12.6 1.0 0.42 9.4 0.2 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.1 EDK38461.2 - 0.15 12.3 0.0 0.15 12.3 0.0 4.1 2 1 1 3 3 2 0 AAA domain cobW PF02492.14 EDK38461.2 - 0.28 10.6 2.3 0.95 8.8 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 EDK38461.2 - 1.1 9.5 12.2 1.3 9.3 0.0 3.6 4 0 0 4 4 2 0 AAA domain MFS_1 PF07690.11 EDK38462.2 - 1.3e-20 73.3 41.0 5.2e-13 48.4 6.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Trehalase PF01204.13 EDK38463.2 - 1.1e-175 585.1 2.7 1.3e-175 584.9 1.9 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 EDK38463.2 - 1.1e-17 63.0 0.3 2e-17 62.2 0.2 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain polyprenyl_synt PF00348.12 EDK38464.2 - 2.4e-51 174.0 0.1 3e-23 81.9 0.0 3.2 3 0 0 3 3 3 3 Polyprenyl synthetase Ribosomal_L3 PF00297.17 EDK38465.2 - 1.1e-34 119.9 2.9 9.8e-34 116.9 2.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L3 Ribosomal_L6 PF00347.18 EDK38466.2 - 3.4e-24 85.1 3.5 1.5e-11 44.6 1.1 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S4 PF00163.14 EDK38467.2 - 1.1e-24 86.5 2.2 1.9e-24 85.8 1.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 EDK38467.2 - 4.8e-09 35.5 0.0 1.3e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 S4 domain SKG6 PF08693.5 EDK38468.2 - 3.8e-09 35.7 0.1 6.6e-09 34.9 0.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.1 EDK38468.2 - 0.013 15.0 0.0 0.06 12.8 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF1191 PF06697.7 EDK38468.2 - 0.016 14.0 0.0 0.031 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Ferric_reduct PF01794.14 EDK38469.2 - 8.9e-23 80.7 13.8 8.9e-23 80.7 9.6 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EDK38469.2 - 2.3e-21 75.6 0.0 3.9e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EDK38469.2 - 1.9e-19 70.1 0.0 3.2e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Flu_NS2 PF00601.14 EDK38470.2 - 0.0092 16.1 0.7 0.014 15.5 0.5 1.3 1 0 0 1 1 1 1 Influenza non-structural protein (NS2) HAUS6_N PF14661.1 EDK38470.2 - 3.5 6.8 9.1 4.7 6.4 6.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Acetyltransf_1 PF00583.19 EDK38471.2 - 4.5e-12 45.8 0.0 9.6e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EDK38471.2 - 1.3e-06 28.4 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK38471.2 - 0.016 15.3 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK38471.2 - 0.019 14.8 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.1 EDK38471.2 - 0.045 13.6 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.2 EDK38472.2 - 2.1e-65 221.2 0.0 3.6e-65 220.5 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 EDK38472.2 - 1.7e-12 47.3 0.1 6.2e-12 45.5 0.1 2.1 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region SRF-TF PF00319.13 EDK38473.2 - 3.6e-22 77.3 0.0 5.5e-22 76.7 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_S6e PF01092.14 EDK38474.1 - 3.8e-47 159.0 0.6 7.8e-47 158.0 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e zinc_ribbon_6 PF14599.1 EDK38475.2 - 1.7e-26 91.8 1.7 1.7e-26 91.8 1.1 4.2 3 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.7 EDK38475.2 - 1.8e-15 56.8 24.4 1.8e-15 56.8 16.9 4.6 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.1 EDK38475.2 - 2.2e-07 30.5 8.9 2.2e-07 30.5 6.2 5.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 EDK38475.2 - 3.5e-06 26.5 10.4 3.5e-06 26.5 7.2 6.0 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK38475.2 - 5.6e-06 26.2 7.4 5.6e-06 26.2 5.1 6.1 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38475.2 - 2.5e-05 23.9 11.6 2.5e-05 23.9 8.1 6.2 4 1 2 6 6 6 1 zinc-RING finger domain PRP21_like_P PF12230.3 EDK38476.2 - 4.6e-62 209.5 6.1 8.2e-62 208.6 4.2 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 EDK38476.2 - 1.2e-20 72.8 0.0 8.8e-11 41.2 0.0 2.5 2 0 0 2 2 2 2 Surp module NIF PF03031.13 EDK38477.2 - 1.7e-47 161.0 0.2 2.5e-47 160.5 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ashwin PF15323.1 EDK38477.2 - 0.021 14.8 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Developmental protein Aminotran_1_2 PF00155.16 EDK38479.1 - 7.7e-73 245.5 0.0 8.7e-73 245.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EDK38479.1 - 0.13 10.7 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase zf-H2C2_2 PF13465.1 EDK38480.2 - 2e-06 27.8 2.5 2e-06 27.8 1.8 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EDK38480.2 - 2.8e-06 27.3 20.5 1.9e-05 24.6 1.1 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK38480.2 - 5.9e-06 26.2 17.8 0.00031 20.8 0.8 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 EDK38480.2 - 0.18 12.0 7.8 9.8 6.5 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EDK38480.2 - 0.23 11.4 6.5 0.79 9.7 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Ldh_1_C PF02866.13 EDK38481.1 - 7.3e-46 156.0 0.3 1.2e-45 155.3 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 EDK38481.1 - 2.7e-44 150.4 0.1 4.5e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 EDK38481.1 - 9.4e-06 25.7 0.1 2.3e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 EDK38481.1 - 0.0064 15.2 0.0 0.0092 14.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.14 EDK38481.1 - 0.013 14.5 0.1 0.12 11.4 0.0 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.19 EDK38481.1 - 0.061 13.6 0.2 0.59 10.4 0.0 2.3 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Tau95 PF09734.4 EDK38482.2 - 2.6e-68 230.6 0.4 4.1e-68 229.9 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit VTC PF09359.5 EDK38482.2 - 0.0076 15.2 0.2 0.0076 15.2 0.1 1.6 2 0 0 2 2 2 1 VTC domain Tom22 PF04281.8 EDK38482.2 - 0.62 9.5 6.2 7 6.1 5.0 2.0 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 DPM3 PF08285.6 EDK38483.1 - 7.5e-38 128.2 0.3 8.2e-38 128.1 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) GSAP-16 PF14959.1 EDK38483.1 - 0.065 12.9 0.4 0.092 12.4 0.2 1.5 1 1 0 1 1 1 0 gamma-Secretase-activating protein C-term Oxidored-like PF09791.4 EDK38484.2 - 1.7e-26 91.3 1.7 1.7e-26 91.3 1.2 1.9 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal PHO4 PF01384.15 EDK38485.2 - 1.2e-113 379.0 18.4 1.5e-113 378.7 12.8 1.1 1 0 0 1 1 1 1 Phosphate transporter family DUF4225 PF13988.1 EDK38485.2 - 0.28 10.6 3.8 11 5.4 0.4 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4225) F_actin_cap_B PF01115.12 EDK38486.2 - 3.7e-98 327.5 0.1 4.3e-98 327.3 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit NPCC PF08058.6 EDK38488.2 - 0.034 13.9 3.0 0.12 12.2 0.2 2.5 1 1 1 2 2 2 0 Nuclear pore complex component Clathrin_lg_ch PF01086.12 EDK38489.2 - 1.1e-58 198.8 21.4 1.3e-58 198.5 14.8 1.1 1 0 0 1 1 1 1 Clathrin light chain DUF3492 PF11997.3 EDK38489.2 - 0.012 15.2 2.5 0.015 14.8 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Phosducin PF02114.11 EDK38489.2 - 0.049 12.3 4.0 0.099 11.3 2.7 1.5 1 1 0 1 1 1 0 Phosducin DUF87 PF01935.12 EDK38489.2 - 4.2 7.1 7.5 3.9 7.2 4.5 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF87 Ribosomal_L30_N PF08079.7 EDK38489.2 - 9 6.4 11.5 1.7 8.7 4.6 2.1 1 1 1 2 2 2 0 Ribosomal L30 N-terminal domain F-box-like PF12937.2 EDK38490.2 - 1.1e-07 31.3 0.0 3.2e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK38490.2 - 1e-05 25.0 0.0 3.2e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 F-box domain PH_9 PF15410.1 EDK38491.2 - 1.7e-05 24.9 0.0 0.00062 19.9 0.0 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain Polyketide_cyc PF03364.15 EDK38492.2 - 3.2e-21 75.6 0.1 4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 EDK38492.2 - 0.0066 16.6 0.0 0.0096 16.0 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Ribosomal_S25 PF03297.10 EDK38493.1 - 8.3e-43 144.7 3.8 9.2e-43 144.5 2.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Ftsk_gamma PF09397.5 EDK38493.1 - 0.0007 19.2 0.0 0.00098 18.7 0.0 1.2 1 0 0 1 1 1 1 Ftsk gamma domain RPA_C PF08784.6 EDK38493.1 - 0.11 12.8 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Replication protein A C terminal Ran_BP1 PF00638.13 EDK38494.2 - 4.5e-24 84.8 0.1 8.5e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.6 EDK38494.2 - 7.7e-13 48.6 1.3 7.7e-13 48.6 0.9 5.8 3 2 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) WH1 PF00568.18 EDK38494.2 - 0.0038 16.9 0.0 0.1 12.3 0.0 2.4 2 0 0 2 2 2 1 WH1 domain Copine PF07002.11 EDK38494.2 - 0.67 9.6 2.9 8.4 6.1 0.1 3.4 3 1 1 4 4 4 0 Copine Dynactin PF12455.3 EDK38495.2 - 0.0023 16.8 0.3 0.0038 16.1 0.2 1.2 1 0 0 1 1 1 1 Dynein associated protein PEP-utilisers_N PF05524.8 EDK38495.2 - 0.077 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal CTDII PF01556.13 EDK38496.2 - 3.9e-26 90.7 3.1 6.8e-20 70.7 0.6 3.4 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 EDK38496.2 - 2e-23 81.8 6.3 4.3e-23 80.8 4.4 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EDK38496.2 - 1.9e-11 43.8 21.6 3e-11 43.2 15.0 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 EDK38496.2 - 4.4 7.0 8.7 9.5 5.9 0.8 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family AcetylCoA_hydro PF02550.10 EDK38497.1 - 4.2e-66 222.4 0.0 7.9e-66 221.5 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 EDK38497.1 - 2.9e-43 147.1 0.0 4.3e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CoA_trans PF01144.18 EDK38497.1 - 0.093 11.8 0.0 0.22 10.6 0.0 1.7 1 0 0 1 1 1 0 Coenzyme A transferase DUF3835 PF12927.2 EDK38498.2 - 1.1e-11 45.5 3.0 1.1e-11 45.5 2.1 5.4 5 2 0 5 5 5 2 Domain of unknown function (DUF3835) Prefoldin PF02996.12 EDK38498.2 - 4.2e-07 29.6 0.1 1.6e-06 27.7 0.1 2.1 1 0 0 1 1 1 1 Prefoldin subunit TBCA PF02970.11 EDK38499.1 - 7.4e-25 86.8 10.0 8.1e-25 86.7 6.9 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF2361 PF10153.4 EDK38499.1 - 0.00088 19.4 3.9 0.001 19.2 2.7 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2361) DUF1837 PF08878.6 EDK38499.1 - 0.059 12.9 0.8 0.072 12.6 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1837) ATP_bind_1 PF03029.12 EDK38500.2 - 4.1e-71 239.2 0.0 5.2e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 EDK38500.2 - 0.0091 14.7 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 1 ArgK protein MMR_HSR1 PF01926.18 EDK38500.2 - 0.03 14.2 0.1 0.33 10.9 0.1 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_10 PF12846.2 EDK38500.2 - 0.053 12.9 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.1 EDK38500.2 - 0.065 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EDK38500.2 - 0.067 13.0 0.0 0.18 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 EDK38500.2 - 0.13 11.6 0.0 0.45 9.8 0.0 1.9 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.22 EDK38500.2 - 0.16 11.4 0.0 22 4.4 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 EDK38500.2 - 0.72 10.6 8.0 0.14 12.9 1.5 2.8 2 2 0 2 2 2 0 AAA domain MitMem_reg PF13012.1 EDK38501.2 - 1.3e-40 138.1 1.3 2.9e-40 136.9 0.9 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 EDK38501.2 - 1e-27 96.1 0.0 1.8e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.13 EDK38502.2 - 5.4e-26 91.3 17.2 1.4e-25 90.0 11.9 1.6 1 1 0 1 1 1 1 UbiA prenyltransferase family PDGLE PF13190.1 EDK38502.2 - 0.082 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 PDGLE domain Hexokinase_2 PF03727.11 EDK38503.2 - 2.1e-75 253.0 0.0 3.1e-75 252.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 EDK38503.2 - 1.9e-70 236.3 0.1 3.2e-70 235.6 0.1 1.4 1 0 0 1 1 1 1 Hexokinase Glutaredoxin PF00462.19 EDK38504.2 - 2.6e-05 24.0 0.0 5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Cytochrom_NNT PF03264.9 EDK38504.2 - 0.0042 16.5 1.4 0.006 16.0 1.0 1.3 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Thioredoxin_9 PF14595.1 EDK38504.2 - 0.0067 15.9 0.1 0.011 15.2 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 EDK38504.2 - 0.0073 16.4 0.1 0.028 14.5 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain DUF1148 PF06618.6 EDK38504.2 - 0.073 13.0 0.0 0.094 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1148) DUF953 PF06110.6 EDK38504.2 - 0.12 11.8 0.8 0.24 10.8 0.4 1.6 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) SHMT PF00464.14 EDK38505.1 - 1.3e-208 692.2 0.1 1.5e-208 692.0 0.1 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 EDK38505.1 - 2.6e-07 29.9 0.0 8.2e-07 28.2 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 EDK38505.1 - 4e-06 25.8 0.0 5.8e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EDK38505.1 - 0.00032 19.9 0.0 0.00074 18.7 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Cut12 PF11500.3 EDK38505.1 - 0.11 12.2 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Spindle pole body formation-associated protein Pyridoxal_deC PF00282.14 EDK38505.1 - 0.15 10.4 0.1 0.53 8.6 0.0 1.8 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain ORMDL PF04061.9 EDK38506.1 - 3.8e-57 191.6 5.4 4.7e-57 191.3 3.8 1.1 1 0 0 1 1 1 1 ORMDL family RCC1_2 PF13540.1 EDK38507.2 - 4.1e-18 64.4 3.5 8.6e-09 34.7 0.0 6.0 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 EDK38507.2 - 9.4e-16 57.7 0.6 0.00014 21.9 0.1 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat bZIP_2 PF07716.10 EDK38508.2 - 2e-06 27.4 9.0 2e-06 27.4 6.2 1.8 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EDK38508.2 - 2.6e-06 27.2 6.9 2.6e-06 27.2 4.8 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.12 EDK38508.2 - 0.012 15.8 5.0 0.023 15.0 3.4 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF4637 PF15470.1 EDK38508.2 - 0.012 15.1 0.4 0.012 15.1 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF848 PF05852.6 EDK38508.2 - 0.016 15.0 3.6 0.017 15.0 1.8 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) LAG1-DNAbind PF09271.6 EDK38508.2 - 0.1 13.0 1.4 0.17 12.3 0.5 1.7 1 1 0 1 1 1 0 LAG1, DNA binding Fib_alpha PF08702.5 EDK38508.2 - 0.3 11.2 2.6 0.51 10.4 1.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AhpC-TSA PF00578.16 EDK38510.2 - 5.5e-26 90.6 0.0 9.7e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EDK38510.2 - 5.3e-20 71.4 0.0 7.4e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 EDK38510.2 - 0.0013 18.6 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Metallophos PF00149.23 EDK38511.2 - 1.6e-16 60.3 8.6 2.9e-16 59.4 6.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase OSCP PF00213.13 EDK38512.2 - 5.9e-46 156.4 3.8 6.9e-46 156.2 2.6 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Ribosomal_L2_C PF03947.13 EDK38513.1 - 1.6e-47 160.5 4.2 3.3e-47 159.5 2.9 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 EDK38513.1 - 2.9e-26 91.2 0.8 8.3e-26 89.7 0.6 1.9 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain TPP1 PF10341.4 EDK38514.2 - 9.6e-23 80.1 0.2 1.5e-22 79.5 0.2 1.3 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Lactamase_B_2 PF12706.2 EDK38515.2 - 1.2e-35 122.8 0.3 2.1e-35 122.0 0.2 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 EDK38515.2 - 4e-23 80.6 0.1 9.8e-23 79.4 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease DUF2183 PF09949.4 EDK38515.2 - 0.073 13.0 0.2 25 4.8 0.0 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2183) DUF3336 PF11815.3 EDK38516.2 - 4e-43 146.4 2.4 8.2e-43 145.3 1.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EDK38516.2 - 2.2e-25 89.7 0.0 5.2e-25 88.5 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase Zip PF02535.17 EDK38517.2 - 2.8e-26 92.2 12.4 7e-18 64.6 2.5 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter F-box PF00646.28 EDK38518.2 - 2e-07 30.4 0.1 8.1e-07 28.5 0.1 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EDK38518.2 - 4.5e-05 23.0 0.1 0.00013 21.6 0.1 1.8 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.12 EDK38518.2 - 0.00026 20.6 0.5 0.36 10.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK38518.2 - 0.00075 18.9 1.6 0.022 14.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38518.2 - 0.0013 18.6 1.5 1.1 9.2 0.1 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK38518.2 - 0.0019 17.7 3.8 0.029 14.0 1.1 3.0 2 1 1 3 3 3 2 TPR repeat TPR_7 PF13176.1 EDK38518.2 - 0.023 14.4 0.1 0.7 9.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DIX PF00778.12 EDK38518.2 - 0.04 13.6 0.2 5.6 6.7 0.0 2.5 2 0 0 2 2 2 0 DIX domain HHH_8 PF14716.1 EDK38518.2 - 0.043 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain U3_snoRNA_assoc PF08297.6 EDK38519.2 - 5.1e-24 84.3 2.7 5.1e-24 84.3 1.9 2.9 2 1 0 2 2 2 1 U3 snoRNA associated SOBP PF15279.1 EDK38519.2 - 2.2 8.5 11.7 2.7 8.3 8.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Mif2_N PF15624.1 EDK38519.2 - 8.7 6.9 17.3 3.4 8.2 9.1 2.0 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal zf-B_box PF00643.19 EDK38520.2 - 0.079 12.8 1.3 0.079 12.8 0.9 2.4 2 0 0 2 2 2 0 B-box zinc finger Elf1 PF05129.8 EDK38520.2 - 0.1 12.2 3.6 0.2 11.3 0.2 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like NMT1 PF09084.6 EDK38521.1 - 2e-76 256.3 0.0 2.5e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 EDK38521.1 - 1.8e-06 27.5 0.0 0.011 15.0 0.0 2.8 2 1 1 3 3 3 2 NMT1-like family Phosphonate-bd PF12974.2 EDK38521.1 - 0.051 12.9 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein PTS_2-RNA PF01885.11 EDK38522.2 - 2.9e-62 209.3 0.2 3.2e-62 209.1 0.1 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PARP PF00644.15 EDK38522.2 - 0.12 11.7 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain Complex1_LYR PF05347.10 EDK38523.2 - 1.3e-06 28.1 0.2 2e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EDK38523.2 - 0.00011 22.3 0.3 0.00016 21.8 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Utp8 PF10395.4 EDK38524.2 - 2.3e-221 736.7 3.0 2.7e-221 736.4 2.0 1.0 1 0 0 1 1 1 1 Utp8 family HAD_2 PF13419.1 EDK38525.1 - 1.6e-16 61.0 0.0 2.8e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK38525.1 - 9.5e-10 39.2 0.0 2.2e-07 31.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EDK38525.1 - 5.5e-07 29.2 0.2 1.1e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 EDK38525.1 - 0.021 14.7 0.1 0.21 11.4 0.1 2.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK38525.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ribosomal_L23 PF00276.15 EDK38526.1 - 3.6e-19 68.4 1.4 4.4e-19 68.2 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 Phage_G PF02306.10 EDK38526.1 - 0.076 12.6 0.0 0.082 12.5 0.0 1.0 1 0 0 1 1 1 0 Major spike protein (G protein) USP7_ICP0_bdg PF12436.3 EDK38526.1 - 0.079 12.1 0.1 0.079 12.1 0.1 1.1 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 RRM_3 PF08777.6 EDK38526.1 - 0.079 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Ribosomal_S11 PF00411.14 EDK38527.2 - 2.3e-06 27.7 0.0 3.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Pkinase PF00069.20 EDK38528.1 - 1.1e-57 195.1 0.0 1.3e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38528.1 - 3.2e-26 91.9 0.0 4.4e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38528.1 - 0.0006 18.8 0.0 0.0019 17.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK38528.1 - 0.0066 15.5 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 EDK38528.1 - 0.094 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase YodA PF09223.6 EDK38528.1 - 0.12 12.0 0.1 0.23 11.0 0.0 1.5 2 0 0 2 2 2 0 YodA lipocalin-like domain DUF1138 PF06592.8 EDK38528.1 - 0.12 12.3 0.0 25 4.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) UPF0220 PF05255.6 EDK38529.1 - 2.3e-72 241.6 4.9 2.6e-72 241.4 3.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) WD40 PF00400.27 EDK38530.2 - 2.5e-45 150.7 17.7 5e-09 35.6 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat PQQ_2 PF13360.1 EDK38530.2 - 1.7e-07 30.9 2.4 0.031 13.7 0.1 3.2 1 1 2 3 3 3 3 PQQ-like domain Coatomer_WDAD PF04053.9 EDK38530.2 - 7.7e-07 28.2 0.1 0.0043 15.9 0.0 2.2 2 0 0 2 2 2 2 Coatomer WD associated region Nup160 PF11715.3 EDK38530.2 - 4e-06 25.2 1.4 1.9 6.5 0.0 4.4 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PQQ_3 PF13570.1 EDK38530.2 - 1.6e-05 25.0 0.9 0.023 14.9 0.1 3.4 3 0 0 3 3 3 2 PQQ-like domain MMS1_N PF10433.4 EDK38530.2 - 0.00029 19.1 0.0 0.004 15.3 0.0 2.3 1 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Cytochrom_D1 PF02239.11 EDK38530.2 - 0.0014 16.9 0.9 0.051 11.8 0.1 2.9 2 1 1 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.16 EDK38530.2 - 0.024 14.1 0.9 12 5.6 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat DUF3312 PF11768.3 EDK38530.2 - 0.075 11.2 0.0 0.22 9.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Pkinase PF00069.20 EDK38532.2 - 6.9e-64 215.4 0.0 4.7e-63 212.7 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38532.2 - 1e-43 149.3 0.0 2.1e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38532.2 - 5.9e-06 25.4 0.0 1.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK38532.2 - 0.054 12.5 0.0 0.16 11.0 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CorA PF01544.13 EDK38533.2 - 1.7e-05 23.9 3.6 2.9e-05 23.2 2.5 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CobD_Cbib PF03186.8 EDK38533.2 - 0.09 11.8 0.2 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 CobD/Cbib protein RhoGAP PF00620.22 EDK38534.2 - 0.00011 21.7 0.6 0.00028 20.5 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain Snapin_Pallidin PF14712.1 EDK38534.2 - 0.032 14.5 1.1 0.15 12.3 0.0 2.6 2 0 0 2 2 2 0 Snapin/Pallidin rve_3 PF13683.1 EDK38534.2 - 0.041 13.4 0.0 0.24 10.9 0.0 2.5 1 0 0 1 1 1 0 Integrase core domain CENP-O PF09496.5 EDK38535.2 - 2.8e-23 81.9 0.4 6e-23 80.8 0.3 1.6 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component DivIC PF04977.10 EDK38535.2 - 0.037 13.5 1.1 0.11 11.9 0.6 1.9 2 0 0 2 2 2 0 Septum formation initiator Spc24 PF08286.6 EDK38535.2 - 0.3 10.8 2.9 3.3 7.4 2.0 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Clathrin PF00637.15 EDK38536.2 - 6.2e-190 622.4 53.5 4.8e-32 110.5 0.5 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 EDK38536.2 - 1.5e-25 88.8 2.2 2.3e-25 88.2 0.5 2.3 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.15 EDK38536.2 - 1.4e-17 62.6 1.8 0.044 14.0 0.0 6.8 6 0 0 6 6 6 4 Clathrin propeller repeat Clathrin-link PF09268.5 EDK38536.2 - 1.2e-05 24.2 0.0 3.7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_1 PF00515.23 EDK38536.2 - 0.00011 21.6 2.9 20 4.9 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 EDK38536.2 - 0.00095 18.7 4.8 24 5.0 0.0 7.6 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38536.2 - 0.0052 16.6 5.0 12 5.9 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38536.2 - 0.0091 15.8 10.7 5.4 7.1 0.0 7.0 6 1 1 7 7 7 1 Tetratricopeptide repeat DUF2422 PF10337.4 EDK38537.2 - 0.14 10.9 0.1 0.23 10.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Eapp_C PF10238.4 EDK38537.2 - 6.2 6.7 7.9 33 4.3 3.7 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein LIM PF00412.17 EDK38539.2 - 6.9e-17 61.2 22.5 9.1e-10 38.4 4.5 2.6 2 1 0 2 2 2 2 LIM domain zinc_ribbon_2 PF13240.1 EDK38539.2 - 0.064 12.7 8.7 0.062 12.8 1.1 3.5 3 1 0 3 3 3 0 zinc-ribbon domain SNARE_assoc PF09335.6 EDK38540.2 - 1.2e-16 61.0 7.5 1.2e-16 61.0 5.2 2.6 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF4231 PF14015.1 EDK38540.2 - 2.2 8.2 9.6 14 5.6 0.1 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF4231) DnaG_DnaB_bind PF08278.6 EDK38541.1 - 0.057 13.6 0.2 0.17 12.0 0.1 1.9 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding Sugar_tr PF00083.19 EDK38542.2 - 6e-19 67.9 5.8 7.5e-19 67.6 4.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK38542.2 - 3.6e-18 65.4 14.8 5e-10 38.6 9.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_2 PF12679.2 EDK38542.2 - 1.5 7.6 8.3 1.2 7.9 4.8 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein Sensor PF13796.1 EDK38542.2 - 2.7 7.5 10.9 0.028 14.0 1.0 2.5 3 1 0 3 3 3 0 Putative sensor Esterase PF00756.15 EDK38543.2 - 3.6e-45 154.3 0.1 4.3e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 EDK38543.2 - 6.1e-10 39.0 0.0 8.4e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 EDK38543.2 - 2.1e-07 30.1 0.0 2.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 EDK38543.2 - 0.00021 20.2 0.0 0.027 13.2 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase Peptidase_S9 PF00326.16 EDK38543.2 - 0.00047 19.4 0.4 0.00077 18.7 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.20 EDK38543.2 - 0.0072 15.9 0.0 0.012 15.2 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 EDK38543.2 - 0.016 15.0 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 EDK38543.2 - 0.1 12.1 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein GCIP PF13324.1 EDK38544.2 - 2.5e-05 23.6 0.2 3.3e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting WH1 PF00568.18 EDK38546.2 - 8.7e-29 99.4 0.0 1.7e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 WH1 domain TMA7 PF09072.5 EDK38547.1 - 9.2e-27 93.2 18.3 1e-26 93.1 12.7 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 rRNA_processing PF08524.6 EDK38547.1 - 0.021 14.6 3.2 0.023 14.4 2.2 1.1 1 0 0 1 1 1 0 rRNA processing FACT-Spt16_Nlob PF14826.1 EDK38547.1 - 0.3 10.6 2.2 0.34 10.4 1.5 1.0 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain EIN3 PF04873.8 EDK38547.1 - 0.91 8.7 6.2 1 8.5 4.3 1.0 1 0 0 1 1 1 0 Ethylene insensitive 3 Ribosomal_L17 PF01196.14 EDK38548.2 - 2.7e-21 75.9 0.1 4.2e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 DUF3701 PF12482.3 EDK38548.2 - 0.14 11.8 0.1 6.6 6.5 0.0 2.9 2 1 1 3 3 3 0 Phage integrase protein adh_short PF00106.20 EDK38549.2 - 6.7e-23 81.4 0.0 8.3e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK38549.2 - 1.2e-10 41.5 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK38549.2 - 1.7e-10 40.8 0.0 2.4e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 EDK38549.2 - 0.00042 20.4 0.0 0.00076 19.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 EDK38549.2 - 0.0024 17.8 0.1 0.031 14.2 0.0 2.3 2 1 0 2 2 2 1 NADH(P)-binding THF_DHG_CYH_C PF02882.14 EDK38549.2 - 0.003 16.6 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.5 EDK38549.2 - 0.022 13.9 0.0 0.11 11.5 0.0 1.9 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Semialdhyde_dh PF01118.19 EDK38549.2 - 0.061 13.6 0.0 2.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 EDK38549.2 - 0.079 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 EDK38549.2 - 0.11 11.8 0.0 0.21 11.0 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 EDK38549.2 - 0.12 11.2 0.1 0.45 9.3 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain DEDD_Tnp_IS110 PF01548.12 EDK38549.2 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Transposase MRP-L47 PF06984.8 EDK38551.2 - 3.3e-16 58.9 0.7 5.6e-16 58.2 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Strabismus PF06638.6 EDK38551.2 - 0.081 11.2 4.4 0.11 10.7 3.1 1.1 1 0 0 1 1 1 0 Strabismus protein DUF3213 PF11491.3 EDK38552.2 - 0.3 11.0 2.7 2.5 8.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3213) Fib_alpha PF08702.5 EDK38552.2 - 6.1 6.9 7.9 19 5.3 4.6 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Sec39 PF08314.6 EDK38553.2 - 1.4e-69 234.8 12.5 1.9e-69 234.4 8.7 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 PIF1 PF05970.9 EDK38554.2 - 2.5e-58 197.7 2.4 2.9e-55 187.6 1.6 2.3 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 EDK38554.2 - 7.7e-16 58.2 0.0 2e-15 56.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK38554.2 - 5.4e-05 22.8 0.3 0.00012 21.8 0.2 1.5 1 0 0 1 1 1 1 Part of AAA domain Herpes_Helicase PF02689.9 EDK38554.2 - 7.6e-05 20.6 0.1 0.011 13.5 0.0 2.2 2 0 0 2 2 2 2 Helicase AAA_22 PF13401.1 EDK38554.2 - 8.5e-05 22.7 0.0 0.00031 20.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EDK38554.2 - 0.00015 21.9 0.2 0.00057 20.0 0.0 2.1 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK38554.2 - 0.00029 20.8 0.0 0.00084 19.3 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.1 EDK38554.2 - 0.00035 20.6 0.0 0.0045 17.0 0.0 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.4 EDK38554.2 - 0.00051 19.1 0.1 0.003 16.5 0.1 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SE PF00437.15 EDK38554.2 - 0.0025 16.7 0.1 0.0041 16.0 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Helicase_RecD PF05127.9 EDK38554.2 - 0.0046 16.6 0.2 0.029 14.0 0.2 2.2 1 1 0 1 1 1 1 Helicase PhoH PF02562.11 EDK38554.2 - 0.0048 16.1 0.0 0.0093 15.2 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_14 PF13173.1 EDK38554.2 - 0.0084 16.0 1.7 0.32 10.8 0.0 3.3 3 1 0 3 3 2 1 AAA domain ABC_tran PF00005.22 EDK38554.2 - 0.013 15.8 1.2 0.026 14.8 0.1 2.0 2 0 0 2 2 2 0 ABC transporter TrwB_AAD_bind PF10412.4 EDK38554.2 - 0.013 14.1 0.0 0.037 12.6 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.7 EDK38554.2 - 0.023 14.3 0.0 0.061 12.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.1 EDK38554.2 - 0.026 14.0 0.0 0.072 12.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.24 EDK38554.2 - 0.046 13.2 0.0 3.1 7.2 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase cobW PF02492.14 EDK38554.2 - 0.14 11.5 0.1 0.35 10.3 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 EDK38554.2 - 0.36 10.4 4.8 0.25 11.0 0.3 2.5 2 1 0 2 2 2 0 Archaeal ATPase DEAD PF00270.24 EDK38555.2 - 0.0024 17.3 0.0 0.0066 15.9 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase cNMP_binding PF00027.24 EDK38556.2 - 1.7e-28 98.2 0.1 5.1e-13 48.6 0.0 4.5 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Patatin PF01734.17 EDK38556.2 - 1.6e-20 73.9 1.6 5.6e-20 72.1 1.1 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase Pam17 PF08566.5 EDK38557.2 - 6.7e-68 227.7 0.0 7.9e-68 227.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 DUF1212 PF06738.7 EDK38557.2 - 0.0073 15.7 0.2 0.014 14.8 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1212) SNF2_N PF00176.18 EDK38558.2 - 4.2e-82 275.3 0.9 4.2e-82 275.3 0.6 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 EDK38558.2 - 9.1e-21 73.5 0.0 2.7e-20 72.0 0.0 1.8 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.26 EDK38558.2 - 9.6e-19 67.0 0.0 7.2e-17 61.0 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.1 EDK38558.2 - 8.6e-14 51.4 2.7 8.6e-14 51.4 1.9 3.6 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex DEAD PF00270.24 EDK38558.2 - 4.6e-07 29.4 0.1 2.3e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase HSA PF07529.8 EDK38558.2 - 0.00067 19.3 4.7 0.00067 19.3 3.3 2.9 3 0 0 3 3 3 1 HSA peroxidase PF00141.18 EDK38559.1 - 2.3e-36 125.4 0.0 4.2e-36 124.5 0.0 1.4 1 1 0 1 1 1 1 Peroxidase Ribosomal_L6 PF00347.18 EDK38560.1 - 2.4e-29 101.6 7.3 5.7e-15 55.5 0.8 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 YbbR PF07949.7 EDK38560.1 - 0.07 13.2 3.9 0.38 10.8 0.4 3.1 1 1 1 2 2 2 0 YbbR-like protein BRE PF06113.7 EDK38560.1 - 0.099 11.6 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) Med7 PF05983.6 EDK38561.2 - 1.1e-68 230.0 0.4 1.4e-68 229.7 0.3 1.1 1 0 0 1 1 1 1 MED7 protein Med4 PF10018.4 EDK38561.2 - 0.009 15.4 2.1 0.019 14.4 1.4 1.5 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Adaptin_N PF01602.15 EDK38562.2 - 1.7e-125 419.3 8.2 2.3e-125 418.9 5.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 EDK38562.2 - 9e-20 71.2 5.3 2.7e-19 69.7 0.1 3.3 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 EDK38562.2 - 1.6e-10 40.1 0.1 0.052 13.6 0.0 5.4 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.1 EDK38562.2 - 2e-10 40.8 0.0 8.5e-05 22.7 0.0 4.6 3 1 2 5 5 5 3 HEAT repeats SPO22 PF08631.5 EDK38562.2 - 0.0067 15.5 0.1 0.017 14.1 0.0 1.7 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like Arm PF00514.18 EDK38562.2 - 0.0076 16.0 3.5 3 7.8 0.0 3.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 EDK38562.2 - 0.011 16.2 0.0 1.6 9.3 0.0 4.2 2 1 1 3 3 3 0 HEAT-like repeat Atx10homo_assoc PF09759.4 EDK38562.2 - 0.017 14.8 0.2 8.6 6.1 0.0 3.0 2 1 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain DUF1548 PF07579.6 EDK38562.2 - 0.034 14.2 0.1 0.2 11.7 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1548) DUF2989 PF11207.3 EDK38562.2 - 0.079 12.4 1.7 0.32 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2989) Methyltransf_10 PF05971.7 EDK38564.2 - 4.2e-10 39.2 0.0 6.4e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF890) Lge1 PF11488.3 EDK38564.2 - 0.067 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 Mog1 PF04603.7 EDK38565.2 - 2.6e-14 53.3 1.1 2.7e-11 43.5 0.1 2.2 1 1 1 2 2 2 2 Ran-interacting Mog1 protein NYN PF01936.13 EDK38565.2 - 0.055 13.7 0.1 0.097 12.9 0.1 1.4 1 1 0 1 1 1 0 NYN domain Gly_transf_sug PF04488.10 EDK38566.2 - 5.6e-13 49.1 0.0 1.4e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 EDK38566.2 - 0.0066 14.9 0.1 0.019 13.4 0.0 1.8 2 0 0 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain DUF3375 PF11855.3 EDK38566.2 - 0.024 13.3 1.2 0.038 12.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) TipAS PF07739.8 EDK38566.2 - 0.049 13.9 0.1 0.24 11.7 0.0 2.1 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain I_LWEQ PF01608.12 EDK38566.2 - 0.079 12.8 0.3 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 I/LWEQ domain PIG-X PF08320.7 EDK38567.2 - 6.8e-58 195.3 0.0 9.8e-58 194.8 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 DUF3800 PF12686.2 EDK38568.1 - 0.00028 20.6 1.5 0.00042 20.0 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3800) Apolipo_F PF15148.1 EDK38568.1 - 0.087 12.1 2.4 0.2 10.9 1.6 1.6 1 0 0 1 1 1 0 Apolipoprotein F DUF2141 PF09912.4 EDK38568.1 - 0.11 12.1 2.3 1.7 8.3 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2141) Fucose_iso_N2 PF07882.7 EDK38568.1 - 0.13 11.8 4.5 0.043 13.4 0.4 1.9 1 1 1 2 2 2 0 L-fucose isomerase, second N-terminal domain HalX PF08663.5 EDK38568.1 - 0.31 11.0 7.4 0.16 12.0 2.4 2.5 2 0 0 2 2 2 0 HalX domain DUF2400 PF09674.5 EDK38568.1 - 3 7.4 10.6 5.6 6.6 0.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2400) Spc7 PF08317.6 EDK38568.1 - 4.3 5.9 28.6 0.48 9.0 6.6 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein DUF3602 PF12223.3 EDK38570.2 - 3e-28 98.0 24.3 1.2e-19 70.4 1.7 3.8 1 1 3 4 4 4 4 Protein of unknown function (DUF3602) Dehydrin PF00257.14 EDK38570.2 - 0.00049 20.4 3.5 0.00086 19.6 2.5 1.4 1 1 0 1 1 1 1 Dehydrin DUF1190 PF06693.6 EDK38570.2 - 0.077 13.0 6.6 0.29 11.1 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1190) Ham1p_like PF01725.11 EDK38571.1 - 1.4e-51 174.5 0.0 1.6e-51 174.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family TPK_catalytic PF04263.11 EDK38572.2 - 2.8e-24 85.0 0.1 3.9e-19 68.4 0.0 2.2 2 0 0 2 2 2 2 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 EDK38572.2 - 1.2e-09 37.7 0.5 1.2e-09 37.7 0.3 1.7 2 0 0 2 2 2 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TFIID-31kDa PF02291.10 EDK38573.2 - 1.3e-49 167.3 0.0 1.5e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit ChAPs PF09295.5 EDK38574.2 - 6.6e-159 528.9 0.0 1e-158 528.2 0.0 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.1 EDK38574.2 - 1.3e-06 28.6 0.1 8.5e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 EDK38574.2 - 9.2e-06 25.2 0.2 0.0018 17.8 0.0 3.3 2 1 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 EDK38574.2 - 0.00022 21.7 1.0 0.04 14.6 0.0 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38574.2 - 0.00027 20.6 0.8 3.6 7.7 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 EDK38574.2 - 0.0013 18.8 0.3 0.41 10.8 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 EDK38574.2 - 0.0015 18.1 0.1 0.61 9.9 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK38574.2 - 0.057 14.0 1.0 4.9 8.0 0.0 4.2 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38574.2 - 0.074 13.0 0.0 0.38 10.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 EDK38574.2 - 0.13 11.9 0.4 35 4.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat HIG_1_N PF04588.8 EDK38575.1 - 2.4e-19 68.7 0.2 3.3e-19 68.3 0.2 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Sensor_TM1 PF13755.1 EDK38575.1 - 0.016 14.7 0.1 0.045 13.2 0.0 1.8 1 1 1 2 2 2 0 Sensor N-terminal transmembrane domain Lge1 PF11488.3 EDK38575.1 - 0.069 13.3 4.2 0.11 12.7 2.9 1.3 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 IncA PF04156.9 EDK38575.1 - 0.08 12.5 7.8 0.14 11.7 5.4 1.4 1 0 0 1 1 1 0 IncA protein DUF4131 PF13567.1 EDK38575.1 - 0.086 12.2 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4485 PF14846.1 EDK38575.1 - 0.14 11.9 1.2 0.22 11.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Guanylate_kin PF00625.16 EDK38576.2 - 3.5e-67 225.3 0.0 3.9e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 EDK38576.2 - 5.3e-07 29.5 0.1 2.4e-06 27.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK38576.2 - 1.7e-06 28.3 0.1 7e-06 26.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK38576.2 - 2.1e-06 27.8 0.1 8.7e-06 25.8 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK38576.2 - 3.2e-06 27.9 0.0 6.2e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EDK38576.2 - 1.2e-05 25.4 0.0 8e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EDK38576.2 - 7.3e-05 22.7 0.3 0.00029 20.8 0.2 2.2 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EDK38576.2 - 0.00036 20.6 0.0 0.00071 19.7 0.0 1.5 2 0 0 2 2 1 1 RNA helicase ABC_tran PF00005.22 EDK38576.2 - 0.00038 20.7 0.0 0.00049 20.4 0.0 1.5 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 EDK38576.2 - 0.00055 19.1 0.0 0.00076 18.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 EDK38576.2 - 0.00056 19.6 0.0 0.0011 18.7 0.0 1.6 1 1 0 1 1 1 1 Archaeal ATPase AAA_19 PF13245.1 EDK38576.2 - 0.001 18.7 0.2 0.0048 16.6 0.0 2.1 2 1 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 EDK38576.2 - 0.001 18.9 0.0 0.0039 17.0 0.0 2.0 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EDK38576.2 - 0.0012 18.7 0.0 0.0018 18.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK38576.2 - 0.0018 18.7 0.1 0.0044 17.5 0.0 1.7 1 1 0 1 1 1 1 Miro-like protein T2SE PF00437.15 EDK38576.2 - 0.0028 16.6 0.0 0.0068 15.3 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein NTPase_1 PF03266.10 EDK38576.2 - 0.0031 17.2 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_30 PF13604.1 EDK38576.2 - 0.0043 16.6 0.0 0.11 12.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 EDK38576.2 - 0.0043 16.5 0.4 0.014 14.9 0.0 2.0 2 1 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.7 EDK38576.2 - 0.0047 16.6 0.0 0.0082 15.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DUF2075 PF09848.4 EDK38576.2 - 0.0051 15.8 0.0 0.038 12.9 0.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 EDK38576.2 - 0.0052 16.9 0.3 0.018 15.2 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 EDK38576.2 - 0.0098 14.6 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 EDK38576.2 - 0.013 15.2 0.2 0.032 13.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 EDK38576.2 - 0.014 14.8 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.1 EDK38576.2 - 0.021 14.3 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 EDK38576.2 - 0.032 13.6 0.0 0.09 12.2 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_2 PF07724.9 EDK38576.2 - 0.035 14.0 0.0 0.8 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) MobB PF03205.9 EDK38576.2 - 0.041 13.5 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 EDK38576.2 - 0.051 12.9 0.0 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 EDK38576.2 - 0.08 11.9 0.0 0.11 11.5 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain AAA_23 PF13476.1 EDK38576.2 - 0.084 13.1 2.6 0.15 12.3 1.7 1.8 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.1 EDK38576.2 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.13 EDK38576.2 - 0.13 11.7 0.1 0.18 11.2 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Xpo1 PF08389.7 EDK38577.2 - 6.3e-27 94.3 3.9 6.3e-27 94.3 2.7 3.8 3 1 1 4 4 4 1 Exportin 1-like protein IBN_N PF03810.14 EDK38577.2 - 3.6e-06 26.7 3.6 1.1e-05 25.2 0.6 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain rpo30_N PF12410.3 EDK38577.2 - 0.0044 16.6 0.1 0.039 13.6 0.0 2.4 2 0 0 2 2 2 1 Poxvirus DNA dependent RNA polymerase 30kDa subunit SRP54_N PF02881.14 EDK38578.1 - 0.12 12.5 8.8 3.1 7.9 0.3 3.6 1 1 2 3 3 3 0 SRP54-type protein, helical bundle domain DUF2703 PF10865.3 EDK38578.1 - 0.13 12.1 0.4 18 5.2 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF2703) HMA PF00403.21 EDK38579.2 - 1.6e-45 153.0 7.1 7.2e-15 54.8 0.1 4.5 4 0 0 4 4 4 3 Heavy-metal-associated domain E1-E2_ATPase PF00122.15 EDK38579.2 - 1.8e-45 154.7 2.1 1.3e-44 152.0 0.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 EDK38579.2 - 7.1e-36 124.6 0.0 1.2e-35 123.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK38579.2 - 2.7e-11 44.0 0.0 5.5e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK38579.2 - 0.00072 19.2 2.1 0.041 13.4 0.7 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF59 PF01883.14 EDK38579.2 - 0.12 12.4 2.1 34 4.5 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function DUF59 SART-1 PF03343.8 EDK38580.2 - 2e-80 270.9 66.7 1.8e-61 208.3 22.0 4.1 1 1 3 4 4 4 4 SART-1 family NDUFA12 PF05071.11 EDK38581.2 - 1.3e-06 28.7 10.1 1.3e-06 28.7 7.0 2.5 2 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Asp-B-Hydro_N PF05279.6 EDK38581.2 - 0.0093 15.8 10.6 0.011 15.6 7.3 1.0 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region PX PF00787.19 EDK38582.2 - 2.5e-15 56.2 0.0 3e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 PX domain Pyr_redox_2 PF07992.9 EDK38583.2 - 9.1e-30 104.0 0.0 3.2e-29 102.2 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK38583.2 - 2.2e-17 63.1 0.1 1.2e-14 54.4 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK38583.2 - 5.2e-08 33.1 0.0 2.2e-05 24.6 0.0 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EDK38583.2 - 0.00016 20.6 3.0 0.57 8.9 0.2 3.7 3 1 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.1 EDK38583.2 - 0.00019 21.6 0.0 0.075 13.3 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.12 EDK38583.2 - 0.00039 19.5 0.2 0.0081 15.2 0.0 2.3 2 1 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.1 EDK38583.2 - 0.0008 19.3 0.0 0.019 15.0 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EDK38583.2 - 0.0024 16.8 0.0 1.8 7.4 0.0 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase Shikimate_DH PF01488.15 EDK38583.2 - 0.0033 17.5 0.3 0.78 9.8 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.19 EDK38583.2 - 0.0036 16.1 2.9 0.57 8.9 0.0 2.7 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.1 EDK38583.2 - 0.0052 15.7 0.0 1.4 7.7 0.0 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 EDK38583.2 - 0.04 12.9 0.0 6.1 5.7 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 EDK38583.2 - 0.11 12.2 0.3 18 5.0 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SNARE PF05739.14 EDK38584.2 - 9.8e-12 44.3 2.9 9.8e-12 44.3 2.0 3.2 4 0 0 4 4 4 1 SNARE domain Syntaxin_2 PF14523.1 EDK38584.2 - 2.7e-05 24.1 14.0 2.7e-05 24.1 9.7 2.8 2 1 1 3 3 3 1 Syntaxin-like protein MCPsignal PF00015.16 EDK38584.2 - 0.017 14.6 6.3 0.36 10.3 1.2 2.3 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 EDK38584.2 - 0.18 11.5 11.6 0.09 12.5 1.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF883 PF05957.8 EDK38584.2 - 0.35 11.2 2.1 2.6 8.4 0.1 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ISG65-75 PF11727.3 EDK38584.2 - 0.36 9.8 8.1 2.3 7.1 1.3 2.2 2 0 0 2 2 2 0 Invariant surface glycoprotein Synaptobrevin PF00957.16 EDK38584.2 - 0.5 9.9 3.1 1.1 8.9 0.1 2.7 3 0 0 3 3 3 0 Synaptobrevin Laminin_II PF06009.7 EDK38584.2 - 2.5 7.8 13.3 0.61 9.8 2.0 2.6 3 0 0 3 3 3 0 Laminin Domain II AATF-Che1 PF13339.1 EDK38584.2 - 3.7 7.6 11.6 3.9 7.6 1.2 2.4 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor HalX PF08663.5 EDK38584.2 - 4.7 7.2 10.9 3.5 7.6 0.1 3.9 3 1 1 4 4 4 0 HalX domain DUF948 PF06103.6 EDK38584.2 - 5.2 6.9 6.3 11 5.9 0.1 2.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.5 EDK38584.2 - 6.8 6.8 21.1 0.54 10.3 4.0 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family WD40 PF00400.27 EDK38585.2 - 1.6e-50 167.2 21.6 1.3e-10 40.7 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EDK38585.2 - 0.00019 20.8 0.0 0.67 9.5 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.1 EDK38585.2 - 0.0055 16.4 0.3 1.1 9.0 0.1 3.7 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region ATP-grasp_4 PF13535.1 EDK38585.2 - 0.078 12.7 0.3 0.17 11.6 0.1 1.6 1 1 0 1 1 1 0 ATP-grasp domain Coatomer_WDAD PF04053.9 EDK38585.2 - 0.23 10.2 2.6 0.45 9.2 0.3 2.3 2 1 1 3 3 3 0 Coatomer WD associated region FAD_binding_6 PF00970.19 EDK38586.2 - 2.9e-07 30.5 0.0 1.7e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EDK38586.2 - 0.0028 18.2 0.2 3.9 8.0 0.0 3.0 3 0 0 3 3 3 2 Oxidoreductase NAD-binding domain Hira PF07569.6 EDK38587.2 - 1e-83 279.8 0.6 2.5e-83 278.6 0.4 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.27 EDK38587.2 - 5.1e-13 48.3 8.3 0.015 15.1 0.0 7.1 6 0 0 6 6 6 4 WD domain, G-beta repeat HIRA_B PF09453.5 EDK38587.2 - 4e-10 38.9 1.5 1.1e-09 37.6 1.0 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.7 EDK38587.2 - 0.0031 17.1 3.0 0.17 11.5 0.1 3.8 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat CK_II_beta PF01214.13 EDK38588.2 - 6.8e-70 234.3 0.0 8.2e-70 234.0 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit tRNA-synt_1b PF00579.20 EDK38589.2 - 3.4e-69 233.1 0.0 4.8e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) 3HCDH_N PF02737.13 EDK38589.2 - 0.12 12.0 0.1 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GATA PF00320.22 EDK38590.2 - 0.016 14.5 1.8 0.71 9.2 0.1 2.5 2 0 0 2 2 2 0 GATA zinc finger PNP_UDP_1 PF01048.15 EDK38591.2 - 2.7e-47 160.7 0.0 4.3e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily WD40 PF00400.27 EDK38592.2 - 1.7e-44 148.1 26.5 1.2e-11 44.0 0.2 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 EDK38592.2 - 0.007 16.0 12.2 0.022 14.4 0.7 4.0 1 1 3 5 5 5 3 Transcription factor IIIC subunit delta N-term Serine_rich PF08824.5 EDK38593.2 - 0.04 13.6 1.6 0.51 10.0 0.0 2.7 1 1 2 3 3 3 0 Serine rich protein interaction domain Herpes_UL25 PF01499.11 EDK38593.2 - 0.14 10.3 4.6 0.086 11.1 1.9 1.5 1 1 1 2 2 2 0 Herpesvirus UL25 family AATF-Che1 PF13339.1 EDK38593.2 - 0.3 11.2 3.1 2.2 8.4 1.1 2.3 1 1 0 2 2 2 0 Apoptosis antagonizing transcription factor DivIVA PF05103.8 EDK38593.2 - 0.36 10.8 6.6 0.93 9.5 0.1 2.6 1 1 2 3 3 3 0 DivIVA protein Flagellin_N PF00669.15 EDK38593.2 - 0.98 9.2 7.9 0.64 9.8 0.3 2.4 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Zip PF02535.17 EDK38594.2 - 0.015 14.3 3.8 0.024 13.6 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Innate_immun PF12782.2 EDK38594.2 - 0.45 9.6 9.4 0.7 9.0 6.5 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Transp_cyt_pur PF02133.10 EDK38595.1 - 4.6e-142 473.6 25.9 5.3e-142 473.4 17.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Abhydrolase_6 PF12697.2 EDK38596.2 - 1e-15 58.2 0.0 2.1e-15 57.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK38596.2 - 8.9e-08 31.9 0.3 1.6e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK38596.2 - 0.00011 21.9 0.1 0.00083 19.1 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EDK38596.2 - 0.043 13.2 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative esterase PLA2_B PF01735.13 EDK38597.2 - 9.1e-165 548.5 5.5 4.2e-164 546.3 3.8 1.8 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Nfu_N PF08712.6 EDK38598.2 - 9.5e-29 98.8 0.6 2.2e-28 97.7 0.1 1.9 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 EDK38598.2 - 4.6e-22 77.5 0.0 7.7e-22 76.8 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain RhoGAP PF00620.22 EDK38598.2 - 8.9e-05 22.1 0.2 0.00076 19.1 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain DUF445 PF04286.7 EDK38598.2 - 0.0032 17.0 0.2 0.0033 17.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) YojJ PF10372.4 EDK38598.2 - 0.0045 16.8 1.0 0.0045 16.8 0.7 1.8 2 0 0 2 2 2 1 Bacterial membrane-spanning protein N-terminus ERp29 PF07749.7 EDK38598.2 - 0.3 11.7 2.5 1.6 9.4 0.2 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Nramp PF01566.13 EDK38600.2 - 3.2e-91 305.8 13.2 6.7e-91 304.7 9.1 1.5 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein DUF1352 PF07086.7 EDK38600.2 - 0.35 10.4 11.7 0.27 10.8 3.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1352) DUF4407 PF14362.1 EDK38600.2 - 0.59 9.0 2.7 1.1 8.0 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Asp PF00026.18 EDK38602.2 - 3.5e-61 207.1 0.2 5e-61 206.6 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK38602.2 - 4.3e-08 33.2 0.0 7.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal RVP PF00077.15 EDK38602.2 - 2.2e-05 24.2 0.1 0.35 10.8 0.0 3.7 4 0 0 4 4 4 2 Retroviral aspartyl protease Asp_protease_2 PF13650.1 EDK38602.2 - 0.00025 21.4 0.1 0.094 13.2 0.0 3.6 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.1 EDK38602.2 - 0.0018 17.8 0.0 0.18 11.3 0.0 2.4 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp PF00026.18 EDK38603.2 - 1e-69 235.2 7.5 1.2e-69 235.0 5.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK38603.2 - 1.5e-07 31.4 0.4 3.7e-07 30.2 0.2 1.7 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EDK38603.2 - 1.6e-05 24.5 0.0 9.6e-05 21.9 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal AA_permease_2 PF13520.1 EDK38604.2 - 4.7e-46 157.2 47.2 5.7e-46 156.9 32.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK38604.2 - 1.3e-26 92.9 41.1 1.7e-26 92.6 28.5 1.0 1 0 0 1 1 1 1 Amino acid permease YoqO PF14037.1 EDK38604.2 - 0.014 15.4 5.9 0.3 11.1 0.5 3.0 2 0 0 2 2 2 0 YoqO-like protein DUF3810 PF12725.2 EDK38604.2 - 0.14 11.0 2.1 0.098 11.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) MatE PF01554.13 EDK38605.2 - 1.8e-59 199.9 32.3 1.1e-36 125.8 5.7 2.8 4 0 0 4 4 4 2 MatE Glyco_hydro_76 PF03663.9 EDK38606.2 - 1.3e-136 455.8 17.6 1.7e-136 455.4 12.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 HAD_2 PF13419.1 EDK38607.2 - 3e-17 63.4 0.1 4.4e-17 62.8 0.1 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EDK38607.2 - 5.2e-08 32.4 0.0 1.1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EDK38607.2 - 0.0022 18.4 0.0 0.0032 17.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.21 EDK38607.2 - 0.14 11.6 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Gal4_dimer PF03902.8 EDK38607.2 - 0.15 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Gal4-like dimerisation domain Fungal_trans_2 PF11951.3 EDK38608.2 - 5.5e-49 166.7 0.2 1.4e-48 165.4 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38608.2 - 3.4e-07 30.0 10.8 6.4e-07 29.1 7.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Adap_comp_sub PF00928.16 EDK38609.2 - 1.3e-53 181.7 2.0 2.1e-53 181.0 1.4 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pterin_4a PF01329.14 EDK38610.2 - 1.6e-24 85.4 1.0 1.6e-24 85.4 0.7 1.5 2 0 0 2 2 2 1 Pterin 4 alpha carbinolamine dehydratase Ferritin PF00210.19 EDK38610.2 - 0.018 14.7 0.7 0.029 14.1 0.5 1.4 1 0 0 1 1 1 0 Ferritin-like domain IMD PF08397.6 EDK38610.2 - 0.023 13.9 1.1 0.033 13.4 0.7 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF3510 PF12022.3 EDK38610.2 - 0.06 13.4 4.0 0.23 11.5 0.9 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3510) Cna_B PF05738.8 EDK38612.2 - 2.2 8.1 5.8 1e+02 2.7 0.3 4.2 4 0 0 4 4 4 0 Cna protein B-type domain Helicase_C PF00271.26 EDK38613.2 - 1.3e-13 50.5 0.0 3.9e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 EDK38613.2 - 7.8e-13 48.3 0.0 7.8e-13 48.3 0.0 2.8 2 1 0 2 2 1 1 Helicase associated domain (HA2) DEAD PF00270.24 EDK38613.2 - 7.2e-09 35.3 0.0 1.7e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK38613.2 - 5.2e-06 26.6 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 EDK38613.2 - 0.0017 17.3 0.0 0.0031 16.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 EDK38613.2 - 0.0022 17.8 4.0 0.49 10.1 0.0 3.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit KaiC PF06745.8 EDK38613.2 - 0.015 14.4 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 KaiC Flavi_DEAD PF07652.9 EDK38613.2 - 0.032 13.9 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain FtsK_SpoIIIE PF01580.13 EDK38613.2 - 0.048 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.11 EDK38613.2 - 0.079 12.1 0.1 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Zip PF02535.17 EDK38613.2 - 5.5 5.8 4.7 9.1 5.1 3.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Synaptobrevin PF00957.16 EDK38614.2 - 5.9e-25 86.6 0.4 8.5e-25 86.1 0.3 1.2 1 0 0 1 1 1 1 Synaptobrevin ADIP PF11559.3 EDK38614.2 - 0.03 14.2 0.6 0.037 13.9 0.4 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Herpes_UL6 PF01763.11 EDK38614.2 - 0.06 11.5 0.1 0.07 11.3 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like ALS2CR8 PF15299.1 EDK38614.2 - 0.093 12.3 0.4 0.18 11.3 0.2 1.6 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 CBFD_NFYB_HMF PF00808.18 EDK38615.2 - 2.5e-07 30.6 0.1 5.6e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK38615.2 - 0.00017 21.6 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.9 EDK38615.2 - 0.028 14.1 1.1 0.032 14.0 0.0 1.6 2 0 0 2 2 2 0 hTAFII28-like protein conserved region DUF2146 PF10220.4 EDK38615.2 - 0.54 8.1 14.2 0.71 7.7 9.8 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Cwf_Cwc_15 PF04889.7 EDK38615.2 - 0.91 9.1 21.8 1.3 8.6 15.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ycf1 PF05758.7 EDK38615.2 - 2.2 5.9 9.3 2.7 5.6 6.4 1.2 1 0 0 1 1 1 0 Ycf1 BUD22 PF09073.5 EDK38615.2 - 4.1 6.3 28.1 5.5 5.9 19.5 1.2 1 0 0 1 1 1 0 BUD22 SAPS PF04499.10 EDK38615.2 - 7.5 5.0 13.6 4.8 5.6 7.9 1.7 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein MOZ_SAS PF01853.13 EDK38616.2 - 8.2e-48 162.1 0.0 1.3e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family Sulfolobus_pRN PF05584.6 EDK38616.2 - 0.47 10.4 1.8 0.82 9.6 0.0 2.2 2 0 0 2 2 2 0 Sulfolobus plasmid regulatory protein zf-C2H2 PF00096.21 EDK38616.2 - 3.3 8.2 6.3 10 6.7 4.4 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type SNF2_N PF00176.18 EDK38617.2 - 2.5e-70 236.6 0.2 3.7e-70 236.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK38617.2 - 1e-11 44.4 0.0 9.4e-11 41.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HIRAN PF08797.6 EDK38617.2 - 2.5e-10 40.2 0.0 8.6e-10 38.5 0.0 2.0 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.1 EDK38617.2 - 9e-08 31.8 8.3 9e-08 31.8 5.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EDK38617.2 - 4e-07 29.5 10.1 7.8e-07 28.6 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38617.2 - 6.5e-07 28.9 8.0 1.2e-06 28.0 5.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK38617.2 - 2.8e-06 27.2 9.5 5.7e-06 26.2 6.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK38617.2 - 5.1e-06 26.0 6.9 8.9e-06 25.2 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK38617.2 - 0.01 15.6 8.7 0.025 14.4 6.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 EDK38617.2 - 0.016 15.2 2.5 0.04 14.0 1.8 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_UBOX PF13445.1 EDK38617.2 - 0.026 14.2 6.0 0.081 12.6 4.2 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 EDK38617.2 - 0.15 11.6 4.3 0.3 10.6 3.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 EDK38617.2 - 0.24 11.2 3.0 0.49 10.2 2.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DAHP_synth_1 PF00793.15 EDK38618.1 - 5.9e-96 320.3 0.0 6.7e-96 320.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family UCH PF00443.24 EDK38619.2 - 2.5e-46 157.9 0.2 4.4e-46 157.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK38619.2 - 5.8e-24 85.0 0.1 3.7e-23 82.3 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EDK38619.2 - 1.3e-20 73.2 4.3 1.3e-20 73.2 2.9 3.6 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 EDK38619.2 - 2e-15 56.0 0.0 1.7e-06 27.6 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain Glyco_hydro_18 PF00704.23 EDK38620.2 - 4.2e-68 230.3 0.8 4.7e-68 230.1 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.8 EDK38620.2 - 0.0023 17.1 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 GPP34 PF05719.6 EDK38621.1 - 2.6e-60 204.0 0.1 3.3e-60 203.6 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PIP5K PF01504.13 EDK38622.2 - 5.2e-62 209.2 3.1 1.1e-61 208.1 2.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 EDK38622.2 - 9.6e-23 80.5 0.7 1.7e-22 79.7 0.5 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 EDK38622.2 - 3.4e-16 58.8 10.1 3.4e-16 58.8 7.0 2.4 2 0 0 2 2 2 1 FYVE zinc finger SUR7 PF06687.7 EDK38623.2 - 2.2e-19 69.8 21.8 3.1e-19 69.3 15.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family LMF1 PF06762.9 EDK38623.2 - 0.025 13.4 0.1 0.034 12.9 0.1 1.2 1 0 0 1 1 1 0 Lipase maturation factor B12D PF06522.6 EDK38624.2 - 0.11 12.2 0.1 0.33 10.6 0.0 1.8 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SNARE PF05739.14 EDK38625.2 - 9e-15 54.1 0.6 9e-15 54.1 0.4 2.7 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 EDK38625.2 - 0.00026 21.1 0.2 0.00026 21.1 0.1 2.4 2 0 0 2 2 2 1 Syntaxin Ribosomal_S6 PF01250.12 EDK38625.2 - 0.026 14.3 1.6 0.041 13.7 0.1 2.1 2 1 1 3 3 3 0 Ribosomal protein S6 DUF3357 PF11837.3 EDK38625.2 - 0.04 13.7 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) MCPsignal PF00015.16 EDK38625.2 - 0.065 12.7 1.4 0.12 11.9 1.0 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMPIT PF07851.8 EDK38625.2 - 0.32 10.0 6.1 0.13 11.3 2.3 1.6 1 1 1 2 2 2 0 TMPIT-like protein Sec20 PF03908.8 EDK38625.2 - 0.46 10.2 6.4 0.17 11.5 0.6 2.8 1 1 1 2 2 2 0 Sec20 Cauli_DNA-bind PF03310.8 EDK38625.2 - 1.3 8.8 5.4 0.72 9.7 0.2 2.6 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein Arrestin_C PF02752.17 EDK38626.2 - 3.9e-16 59.4 0.0 7.1e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EDK38626.2 - 3e-14 53.0 0.0 4.6e-12 45.9 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 EDK38626.2 - 0.019 14.4 0.0 0.049 13.1 0.0 1.6 1 0 0 1 1 1 0 Arrestin_N terminal like Hydantoinase_B PF02538.9 EDK38626.2 - 0.14 10.3 0.0 0.2 9.8 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase LRR_6 PF13516.1 EDK38627.2 - 0.0011 18.8 2.1 16 5.9 0.0 4.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.2 EDK38627.2 - 0.0071 15.9 9.1 4.1 7.1 0.4 4.8 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) DUF2625 PF10946.3 EDK38628.2 - 0.15 10.9 0.4 0.25 10.2 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 NatB_MDM20 PF09797.4 EDK38629.2 - 3.2e-71 239.9 22.1 3.6e-71 239.8 13.5 2.4 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.1 EDK38629.2 - 0.00036 20.8 4.3 15 6.0 0.0 4.8 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK38629.2 - 0.0055 17.2 0.3 5.8 7.8 0.0 4.6 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38629.2 - 0.0084 16.7 0.0 0.2 12.3 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 EDK38629.2 - 0.034 14.2 14.2 0.052 13.6 0.1 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EDK38629.2 - 0.066 13.6 1.2 1.9 9.1 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat E1-E2_ATPase PF00122.15 EDK38630.2 - 4.7e-72 241.7 2.8 9.7e-72 240.7 2.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 EDK38630.2 - 1.9e-29 102.4 1.1 1.9e-29 102.4 0.8 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 EDK38630.2 - 7.4e-29 101.7 0.0 2e-27 97.0 0.0 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK38630.2 - 1.8e-21 75.8 0.0 3.9e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 EDK38630.2 - 2.5e-13 50.6 0.0 5.5e-13 49.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 EDK38630.2 - 1.1e-10 40.8 0.0 2.6e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 EDK38630.2 - 0.00051 19.7 3.1 0.00082 19.0 0.5 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase His_Phos_1 PF00300.17 EDK38631.1 - 1.8e-30 106.0 0.1 2.4e-30 105.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pantoate_transf PF02548.10 EDK38632.1 - 2.2e-105 351.4 0.3 2.6e-105 351.2 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 EDK38632.1 - 2.9e-10 39.7 0.3 7.3e-10 38.4 0.2 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Glyoxalase PF00903.20 EDK38633.2 - 5.3e-37 126.6 0.2 8.9e-18 64.5 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 EDK38633.2 - 2e-25 89.4 0.0 9.7e-13 48.6 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 EDK38633.2 - 4e-12 46.0 0.1 4.9e-05 23.3 0.0 3.9 1 1 3 4 4 4 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 EDK38633.2 - 0.0098 15.8 0.0 1.2 9.0 0.0 2.8 2 1 0 2 2 2 1 Glyoxalase-like domain CppA_N PF14506.1 EDK38633.2 - 0.025 14.2 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 CppA N-terminal UCH PF00443.24 EDK38634.2 - 4.9e-49 166.8 1.1 7.8e-49 166.1 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK38634.2 - 3.2e-13 49.8 9.8 4.4e-12 46.0 6.8 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 EDK38634.2 - 4.5e-10 38.7 0.4 1.4e-09 37.1 0.3 1.9 1 0 0 1 1 1 1 Ubiquitin family MRP-L28 PF09812.4 EDK38634.2 - 0.041 13.7 1.9 0.14 11.9 1.3 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 OST-HTH PF12872.2 EDK38634.2 - 0.045 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Lactamase_B_2 PF12706.2 EDK38635.2 - 5.1e-28 97.9 0.1 6.7e-28 97.5 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 EDK38635.2 - 2.2e-11 43.7 0.0 4.1e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ABC_tran PF00005.22 EDK38636.2 - 2.8e-44 150.7 4.6 2.4e-22 79.6 0.0 3.4 3 1 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 EDK38636.2 - 1.3e-21 76.2 5.1 1.3e-21 76.2 3.5 3.9 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.1 EDK38636.2 - 7.5e-17 62.2 22.8 5e-07 29.9 0.2 5.8 4 2 0 5 5 5 3 AAA domain AAA_17 PF13207.1 EDK38636.2 - 3.1e-09 37.7 5.1 6.4e-05 23.7 0.1 3.8 4 1 0 4 4 3 2 AAA domain SMC_N PF02463.14 EDK38636.2 - 3.2e-09 36.3 3.6 0.0012 18.1 0.5 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EDK38636.2 - 3.8e-06 27.0 0.1 0.0014 18.6 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 EDK38636.2 - 4.6e-06 26.0 0.3 0.062 12.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 EDK38636.2 - 5.4e-06 26.9 0.9 0.18 12.3 0.2 3.5 2 1 0 2 2 2 2 Miro-like protein AAA_28 PF13521.1 EDK38636.2 - 7.4e-06 26.0 1.6 0.036 14.0 0.1 3.1 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 EDK38636.2 - 7.5e-06 25.2 0.0 0.029 13.5 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 EDK38636.2 - 1.1e-05 25.6 2.5 0.23 11.5 0.7 3.8 3 1 0 3 3 2 2 AAA domain MobB PF03205.9 EDK38636.2 - 3.9e-05 23.3 0.7 0.28 10.8 0.1 3.1 3 1 0 3 3 3 2 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 EDK38636.2 - 9.8e-05 22.2 0.0 0.06 13.2 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.24 EDK38636.2 - 0.0001 22.4 2.2 0.34 11.1 0.1 4.3 4 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EDK38636.2 - 0.0003 21.1 14.0 0.074 13.3 0.5 4.8 5 1 0 5 5 4 2 AAA domain AAA_33 PF13671.1 EDK38636.2 - 0.00032 20.5 3.7 0.18 11.6 0.0 3.4 4 0 0 4 4 3 2 AAA domain AAA_25 PF13481.1 EDK38636.2 - 0.00041 19.8 0.0 1.1 8.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 EDK38636.2 - 0.00042 20.0 0.7 0.57 9.8 0.0 2.7 2 0 0 2 2 2 2 NACHT domain PduV-EutP PF10662.4 EDK38636.2 - 0.001 18.5 0.2 1.1 8.7 0.0 2.6 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SbcCD_C PF13558.1 EDK38636.2 - 0.0012 18.7 0.3 1.7 8.6 0.1 3.3 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF812 PF05667.6 EDK38636.2 - 0.0014 17.2 2.3 0.0014 17.2 1.6 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF812) RNA_helicase PF00910.17 EDK38636.2 - 0.0026 17.9 0.1 3.7 7.7 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_10 PF12846.2 EDK38636.2 - 0.0033 16.9 0.1 4.6 6.5 0.2 3.4 3 0 0 3 3 3 0 AAA-like domain AAA_14 PF13173.1 EDK38636.2 - 0.0038 17.1 0.9 0.82 9.5 0.0 3.5 4 0 0 4 4 2 1 AAA domain ATP-synt_ab PF00006.20 EDK38636.2 - 0.0043 16.5 0.0 0.072 12.5 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.1 EDK38636.2 - 0.0052 17.1 38.0 0.15 12.4 0.0 5.2 4 1 1 5 5 4 2 AAA domain Dynamin_N PF00350.18 EDK38636.2 - 0.017 14.9 0.2 0.017 14.9 0.2 4.0 3 1 0 4 4 4 0 Dynamin family ArgK PF03308.11 EDK38636.2 - 0.019 13.7 2.4 0.38 9.4 0.0 3.6 4 0 0 4 4 4 0 ArgK protein T2SE PF00437.15 EDK38636.2 - 0.024 13.5 0.0 0.22 10.3 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF972 PF06156.8 EDK38636.2 - 0.038 14.3 1.0 0.038 14.3 0.7 3.3 3 1 0 3 3 2 0 Protein of unknown function (DUF972) SRP54 PF00448.17 EDK38636.2 - 0.048 13.0 0.3 9.9 5.5 0.2 3.4 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Pox_A32 PF04665.7 EDK38636.2 - 0.098 11.9 3.1 0.4 9.9 0.1 2.8 3 0 0 3 3 3 0 Poxvirus A32 protein Vps39_2 PF10367.4 EDK38636.2 - 4.8 7.4 6.0 1.1 9.4 1.3 2.2 3 0 0 3 3 1 0 Vacuolar sorting protein 39 domain 2 Aldedh PF00171.17 EDK38637.2 - 3e-78 263.2 0.0 3.7e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3764 PF12594.3 EDK38637.2 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) Aldo_ket_red PF00248.16 EDK38638.2 - 4e-50 170.2 0.8 5.2e-50 169.8 0.6 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SnoaL PF07366.7 EDK38639.1 - 1.1e-26 92.8 0.0 1.4e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 EDK38639.1 - 1.2e-17 64.1 0.0 1.5e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain Flavoprotein PF02441.14 EDK38640.2 - 4.7e-26 90.9 0.0 3.2e-25 88.2 0.0 2.1 1 1 0 1 1 1 1 Flavoprotein Abhydrolase_6 PF12697.2 EDK38641.2 - 3e-09 37.0 0.0 3.7e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK38641.2 - 0.00018 21.3 0.0 0.00027 20.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EDK38641.2 - 0.0003 20.0 0.0 0.0055 15.9 0.0 2.5 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 EDK38641.2 - 0.0014 18.0 0.0 0.0042 16.5 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Esterase PF00756.15 EDK38641.2 - 0.0019 17.6 0.0 0.0049 16.3 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Imm20 PF15568.1 EDK38641.2 - 0.0041 17.0 0.0 0.29 11.0 0.0 2.4 2 1 0 2 2 2 1 Immunity protein 20 Lipase_3 PF01764.20 EDK38641.2 - 0.01 15.4 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DLH PF01738.13 EDK38641.2 - 0.015 14.6 0.0 3.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 EDK38641.2 - 0.026 14.0 0.1 0.43 10.0 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold WD40 PF00400.27 EDK38642.2 - 2.5e-12 46.1 2.0 0.00032 20.4 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat CPSF_A PF03178.10 EDK38642.2 - 0.00095 18.3 0.1 0.0048 16.0 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region Coatomer_WDAD PF04053.9 EDK38642.2 - 0.0063 15.3 0.1 0.48 9.1 0.0 2.7 2 2 1 3 3 3 1 Coatomer WD associated region BCAS3 PF12490.3 EDK38642.2 - 0.029 13.6 0.0 0.076 12.3 0.0 1.7 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 PQQ_2 PF13360.1 EDK38642.2 - 0.064 12.7 0.0 0.49 9.8 0.0 2.3 3 0 0 3 3 3 0 PQQ-like domain Serglycin PF04360.7 EDK38642.2 - 0.079 12.6 3.3 0.19 11.4 2.3 1.6 1 0 0 1 1 1 0 Serglycin PBP1_TM PF14812.1 EDK38642.2 - 0.37 11.1 4.9 0.77 10.1 3.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal M_domain PF12938.2 EDK38642.2 - 0.73 9.5 6.6 1.4 8.6 4.6 1.4 1 0 0 1 1 1 0 M domain of GW182 PQQ_3 PF13570.1 EDK38642.2 - 1.4 9.2 4.2 8.9 6.7 0.1 3.6 3 1 1 4 4 4 0 PQQ-like domain FAM176 PF14851.1 EDK38642.2 - 2.9 7.5 5.2 5.2 6.7 3.6 1.3 1 0 0 1 1 1 0 FAM176 family RNB PF00773.14 EDK38643.2 - 3.5e-94 315.7 0.0 5.1e-94 315.1 0.0 1.2 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 EDK38643.2 - 3.7e-17 62.6 0.1 9.9e-17 61.2 0.1 1.8 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 EDK38643.2 - 0.032 13.7 0.2 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease B OB domain DHBP_synthase PF00926.14 EDK38644.2 - 2.9e-82 274.6 0.1 3.2e-82 274.4 0.1 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase tRNA-synt_1b PF00579.20 EDK38645.1 - 5.5e-18 65.1 0.0 9.8e-11 41.3 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Ribosomal_L27e PF01777.13 EDK38646.1 - 2.9e-20 72.1 0.9 3.1e-20 72.0 0.6 1.0 1 0 0 1 1 1 1 Ribosomal L27e protein family Hydrolase_2 PF07486.7 EDK38646.1 - 0.021 15.3 0.0 0.024 15.1 0.0 1.0 1 0 0 1 1 1 0 Cell Wall Hydrolase CDI PF02234.14 EDK38646.1 - 0.23 11.2 1.1 0.31 10.8 0.8 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor MFS_1 PF07690.11 EDK38647.1 - 1.7e-28 99.4 27.1 4.2e-28 98.0 16.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK38647.1 - 0.0022 16.2 2.1 0.0033 15.6 1.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.20 EDK38648.2 - 6.1e-66 222.2 0.1 1.1e-65 221.3 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38648.2 - 2.7e-33 115.1 0.0 3.8e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38648.2 - 8.5e-07 28.2 0.0 6e-06 25.4 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 EDK38648.2 - 6.1e-05 22.1 0.0 0.00011 21.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EDK38648.2 - 0.02 14.2 0.6 0.042 13.1 0.4 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 EDK38648.2 - 0.043 13.5 0.1 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RBD PF02196.10 EDK38649.2 - 0.034 13.8 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 Raf-like Ras-binding domain RNase_T PF00929.19 EDK38650.2 - 7.3e-24 84.8 0.0 1.5e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 Exonuclease RasGAP PF00616.14 EDK38653.2 - 1.8e-32 112.6 7.1 7.9e-32 110.5 3.8 2.9 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase DUF2611 PF11022.3 EDK38654.1 - 4.7e-27 93.8 0.0 5.1e-27 93.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) Brix PF04427.13 EDK38655.2 - 1e-42 145.9 1.3 1.8e-42 145.2 0.9 1.4 1 0 0 1 1 1 1 Brix domain Rhomboid PF01694.17 EDK38656.2 - 2.8e-32 111.7 13.3 2.8e-32 111.7 9.2 2.5 3 0 0 3 3 3 1 Rhomboid family Ribosomal_L50 PF10501.4 EDK38657.1 - 2.7e-33 114.2 2.0 3e-33 114.1 0.8 1.6 2 0 0 2 2 2 1 Ribosomal subunit 39S DUF285 PF03382.9 EDK38657.1 - 0.032 13.8 0.4 0.054 13.0 0.3 1.3 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 CBS PF00571.23 EDK38658.2 - 6.7e-37 125.0 4.2 3.3e-11 42.7 0.0 4.4 4 0 0 4 4 4 4 CBS domain PB1 PF00564.19 EDK38658.2 - 1e-08 34.7 0.1 4.5e-08 32.6 0.2 1.9 2 0 0 2 2 2 1 PB1 domain DUF3592 PF12158.3 EDK38658.2 - 0.033 13.9 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) SporV_AA PF12164.3 EDK38658.2 - 0.063 13.2 0.4 6.3 6.8 0.0 2.9 3 0 0 3 3 3 0 Stage V sporulation protein AA Prenyltransf PF01255.14 EDK38659.1 - 6.9e-75 250.9 0.1 9.6e-75 250.5 0.1 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Vma12 PF11712.3 EDK38660.1 - 4.5e-43 146.3 0.4 6.3e-43 145.8 0.3 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3878 PF12994.2 EDK38660.1 - 0.00057 19.1 0.0 0.00087 18.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3878) MscS_TM PF12794.2 EDK38660.1 - 0.0061 15.2 1.0 0.0095 14.5 0.1 1.7 1 1 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 DUF1673 PF07895.6 EDK38660.1 - 0.021 14.3 0.3 0.03 13.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Ins145_P3_rec PF08709.6 EDK38660.1 - 0.046 12.7 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF4149 PF13664.1 EDK38660.1 - 0.062 13.3 0.0 0.092 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) MerC PF03203.9 EDK38660.1 - 0.094 13.0 0.1 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 MerC mercury resistance protein DsrD PF08679.6 EDK38660.1 - 0.97 9.4 4.0 38 4.3 0.0 3.2 2 1 0 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) tRNA_SAD PF07973.9 EDK38661.2 - 2.1e-11 43.5 0.2 5.5e-11 42.1 0.1 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 EDK38661.2 - 8e-07 27.7 0.0 1.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) Ribosomal_S9 PF00380.14 EDK38662.2 - 1.1e-40 138.6 0.5 2e-40 137.7 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Myb_DNA-binding PF00249.26 EDK38663.2 - 5.6e-11 42.3 0.0 6.8e-05 22.8 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK38663.2 - 0.035 14.2 0.2 1.3 9.1 0.1 2.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain AAA_16 PF13191.1 EDK38664.2 - 1.2e-09 38.4 2.2 3.3e-08 33.7 1.5 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EDK38664.2 - 2.1e-09 37.6 0.1 4.5e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EDK38664.2 - 2.3e-08 34.2 0.0 5.2e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 EDK38664.2 - 0.00016 21.3 0.0 0.00041 20.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 EDK38664.2 - 0.00046 19.9 0.0 0.0008 19.1 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_11 PF13086.1 EDK38664.2 - 0.0016 18.0 0.0 0.0034 16.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 EDK38664.2 - 0.0019 17.0 0.0 0.0032 16.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain NTPase_1 PF03266.10 EDK38664.2 - 0.013 15.2 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 NTPase DUF2075 PF09848.4 EDK38664.2 - 0.034 13.1 0.0 0.067 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.17 EDK38664.2 - 0.048 13.8 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 EDK38664.2 - 0.064 12.9 0.1 0.18 11.4 0.1 1.7 1 1 0 1 1 1 0 NACHT domain Cdc6_C PF09079.6 EDK38664.2 - 0.077 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal KAP_NTPase PF07693.9 EDK38664.2 - 0.14 11.1 2.3 5.7 5.8 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain CENP-S PF15630.1 EDK38665.2 - 9.1e-27 93.0 0.0 1.1e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 EDK38665.2 - 0.0004 19.7 0.0 0.00052 19.3 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 EDK38665.2 - 0.073 12.8 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 Bromodomain associated DUF3337 PF11816.3 EDK38666.2 - 9.8e-71 238.8 7.7 2.3e-70 237.5 4.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.27 EDK38666.2 - 1.3e-18 66.1 14.7 1.5e-06 27.8 0.0 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat DUF4496 PF14908.1 EDK38666.2 - 0.0065 16.3 0.1 0.021 14.7 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4496) RNA_pol_Rpb5_C PF01191.14 EDK38667.1 - 3.6e-32 109.7 0.3 5.2e-32 109.2 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 EDK38667.1 - 8.4e-14 51.7 0.0 1.4e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain SH3_2 PF07653.12 EDK38667.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain RibD_C PF01872.12 EDK38668.2 - 1.4e-29 103.1 0.0 1.8e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 RibD C-terminal domain Prp19_bind PF06991.6 EDK38669.2 - 2.1e-06 27.2 12.4 3.8e-06 26.3 6.0 2.0 1 1 1 2 2 2 2 Splicing factor, Prp19-binding domain HrpA_pilin PF09589.5 EDK38669.2 - 0.007 16.7 0.2 0.013 15.8 0.2 1.6 1 1 0 1 1 1 1 HrpA pilus formation protein Adeno_PIX PF03955.9 EDK38669.2 - 0.14 12.6 0.5 1 9.9 0.1 2.0 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) TMEM156 PF15106.1 EDK38669.2 - 0.14 11.3 1.3 0.16 11.1 0.9 1.3 1 0 0 1 1 1 0 TMEM156 protein family CAF-1_p150 PF11600.3 EDK38669.2 - 0.87 8.9 8.7 1.2 8.4 6.1 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Sox_N PF12444.3 EDK38669.2 - 2.4 9.3 6.8 4.8 8.3 4.7 1.6 1 1 0 1 1 1 0 Sox developmental protein N terminal ELO PF01151.13 EDK38670.1 - 1.6e-60 204.5 16.4 2e-60 204.2 11.4 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PfkB PF00294.19 EDK38671.2 - 6e-56 189.7 0.3 7.2e-56 189.5 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 EDK38671.2 - 6e-06 25.6 0.4 1.1e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PCI PF01399.22 EDK38672.2 - 9.8e-09 35.4 0.2 5.2e-08 33.1 0.1 2.4 1 0 0 1 1 1 1 PCI domain BCIP PF13862.1 EDK38673.1 - 2.4e-68 229.5 6.0 2.9e-68 229.2 4.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein PAXIP1_C PF15364.1 EDK38673.1 - 3.9 7.3 8.8 9.2 6.1 1.7 2.3 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein WD40 PF00400.27 EDK38674.2 - 2.6e-26 90.4 7.1 2.6e-07 30.2 0.1 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat UCH_1 PF13423.1 EDK38675.2 - 1.9e-55 188.4 0.0 4.4e-55 187.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.24 EDK38675.2 - 2.8e-14 52.8 0.0 6.3e-14 51.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BAR PF03114.13 EDK38676.2 - 2.5e-46 158.0 10.3 3.1e-46 157.7 7.1 1.1 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.8 EDK38676.2 - 0.00022 20.6 8.1 0.0004 19.7 5.6 1.5 1 1 0 1 1 1 1 Arfaptin-like domain DUF3338 PF11819.3 EDK38676.2 - 0.022 14.2 0.2 0.022 14.2 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3338) BBE PF08031.7 EDK38676.2 - 0.045 13.6 0.2 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Berberine and berberine like Phasin_2 PF09361.5 EDK38676.2 - 0.053 13.5 3.6 0.98 9.4 0.2 2.8 3 0 0 3 3 3 0 Phasin protein AAA_18 PF13238.1 EDK38676.2 - 0.073 13.3 1.0 0.16 12.3 0.6 1.8 1 1 0 1 1 1 0 AAA domain Vps5 PF09325.5 EDK38676.2 - 0.21 10.8 8.1 0.27 10.4 1.1 2.5 1 1 2 3 3 3 0 Vps5 C terminal like BAR_2 PF10455.4 EDK38676.2 - 0.93 8.3 9.4 3.6 6.4 6.5 2.1 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking AMPKBI PF04739.10 EDK38677.2 - 4.8e-40 135.4 0.5 1.6e-39 133.8 0.4 1.9 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain Glyco_hydro_32N PF00251.15 EDK38679.2 - 3.3e-88 296.0 6.4 3.3e-88 296.0 4.5 1.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.7 EDK38679.2 - 9.1e-11 41.9 0.0 9e-10 38.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 C terminal AAA PF00004.24 EDK38680.2 - 1.6e-52 177.2 0.1 3.4e-39 134.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EDK38680.2 - 6.7e-10 38.7 0.0 2.7e-09 36.8 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.1 EDK38680.2 - 3.9e-09 36.7 1.8 0.00029 20.9 0.3 4.0 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EDK38680.2 - 1.1e-08 35.8 0.0 0.002 18.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_2 PF07724.9 EDK38680.2 - 3.2e-08 33.6 0.1 6.2e-06 26.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 EDK38680.2 - 6.6e-08 32.9 0.1 0.0017 18.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 EDK38680.2 - 3.2e-07 30.5 0.0 0.0066 16.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.8 EDK38680.2 - 7e-07 28.2 0.1 0.016 13.9 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus RuvB_N PF05496.7 EDK38680.2 - 1.1e-06 27.9 0.2 0.027 13.5 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 EDK38680.2 - 1.1e-06 27.9 0.2 0.004 16.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EDK38680.2 - 1.3e-06 28.2 0.2 0.001 18.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 EDK38680.2 - 3.4e-06 26.2 0.1 0.0059 15.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.1 EDK38680.2 - 5.5e-06 26.3 0.0 0.13 12.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.12 EDK38680.2 - 7e-06 25.5 0.7 0.00013 21.5 0.1 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_19 PF13245.1 EDK38680.2 - 9.7e-06 25.2 0.1 0.011 15.4 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain RNA_helicase PF00910.17 EDK38680.2 - 1.1e-05 25.5 0.0 0.027 14.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.1 EDK38680.2 - 1.7e-05 24.7 0.0 0.035 14.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 EDK38680.2 - 2.5e-05 23.7 0.0 0.03 13.7 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein NB-ARC PF00931.17 EDK38680.2 - 0.00013 20.9 0.1 0.51 9.1 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain AAA_25 PF13481.1 EDK38680.2 - 0.00015 21.2 4.1 0.37 10.1 0.0 3.6 2 2 1 3 3 3 2 AAA domain AAA_3 PF07726.6 EDK38680.2 - 0.00015 21.3 0.0 0.043 13.4 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EDK38680.2 - 0.00027 20.9 0.0 0.81 9.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.1 EDK38680.2 - 0.00032 20.3 0.5 0.13 11.8 0.2 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EDK38680.2 - 0.00052 19.1 0.0 0.4 9.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Sigma54_activ_2 PF14532.1 EDK38680.2 - 0.00066 19.7 0.0 1.8 8.6 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain PhoH PF02562.11 EDK38680.2 - 0.00071 18.8 0.5 1.5 8.0 0.0 3.2 3 0 0 3 3 3 1 PhoH-like protein Sigma54_activat PF00158.21 EDK38680.2 - 0.00087 18.8 0.0 0.61 9.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.22 EDK38680.2 - 0.0015 18.8 0.2 0.078 13.2 0.1 2.6 2 0 0 2 2 2 1 ABC transporter KTI12 PF08433.5 EDK38680.2 - 0.0016 17.6 0.1 1.5 7.9 0.0 2.8 3 0 0 3 3 2 1 Chromatin associated protein KTI12 Parvo_NS1 PF01057.12 EDK38680.2 - 0.0018 17.1 0.0 0.62 8.8 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NACHT PF05729.7 EDK38680.2 - 0.0062 16.1 0.2 4.6 6.8 0.0 3.0 2 1 0 2 2 2 0 NACHT domain DEAD PF00270.24 EDK38680.2 - 0.007 15.8 1.2 11 5.4 0.0 3.5 2 2 0 3 3 3 0 DEAD/DEAH box helicase Vps4_C PF09336.5 EDK38680.2 - 0.011 15.6 0.1 0.066 13.1 0.0 2.2 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain ResIII PF04851.10 EDK38680.2 - 0.011 15.5 0.3 4.6 7.0 0.0 2.9 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.1 EDK38680.2 - 0.013 15.0 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EDK38680.2 - 0.013 15.0 0.0 0.6 9.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase KaiC PF06745.8 EDK38680.2 - 0.013 14.5 0.8 1.4 7.9 0.0 3.0 2 1 1 3 3 3 0 KaiC SKI PF01202.17 EDK38680.2 - 0.014 15.3 0.1 11 5.8 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase Torsin PF06309.6 EDK38680.2 - 0.017 15.0 0.0 2.4 8.0 0.0 2.9 3 0 0 3 3 2 0 Torsin Zot PF05707.7 EDK38680.2 - 0.021 14.2 0.2 9.3 5.6 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) CPT PF07931.7 EDK38680.2 - 0.025 14.1 0.1 0.21 11.2 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein UPF0079 PF02367.12 EDK38680.2 - 0.039 13.5 0.0 0.54 9.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 EDK38680.2 - 0.043 13.4 0.0 2 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 EDK38680.2 - 0.066 12.6 0.6 1.6 8.1 0.0 3.2 3 1 0 3 3 3 0 FtsK/SpoIIIE family Arch_ATPase PF01637.13 EDK38680.2 - 0.086 12.5 2.6 4.3 6.9 0.3 3.1 2 2 1 3 3 3 0 Archaeal ATPase IncA PF04156.9 EDK38681.2 - 0.0072 15.9 10.7 0.011 15.2 7.4 1.3 1 0 0 1 1 1 1 IncA protein DUF3981 PF13139.1 EDK38681.2 - 0.009 15.9 0.3 0.016 15.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3981) Fib_alpha PF08702.5 EDK38681.2 - 0.036 14.1 7.6 0.036 14.2 4.5 1.6 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.11 EDK38681.2 - 0.049 13.8 6.6 0.51 10.5 4.6 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 SRA1 PF07304.6 EDK38681.2 - 0.056 13.1 1.2 0.087 12.5 0.7 1.6 1 1 0 1 1 1 0 Steroid receptor RNA activator (SRA1) YrzO PF14142.1 EDK38681.2 - 0.094 12.3 4.9 7.6 6.2 0.2 3.4 1 1 3 4 4 4 0 YrzO-like protein VIT1 PF01988.14 EDK38681.2 - 0.12 11.8 4.7 4.5 6.7 3.2 2.4 1 1 0 1 1 1 0 VIT family DUF2570 PF10828.3 EDK38681.2 - 0.15 11.6 7.5 0.13 11.8 0.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) DUF484 PF04340.7 EDK38681.2 - 0.2 11.0 3.0 0.28 10.6 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF484 CALCOCO1 PF07888.6 EDK38681.2 - 0.22 9.7 8.3 0.28 9.4 5.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF342 PF03961.8 EDK38681.2 - 0.28 9.5 4.0 0.38 9.1 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF148 PF02520.12 EDK38681.2 - 0.3 10.8 7.1 0.92 9.3 1.8 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 FlgN PF05130.7 EDK38681.2 - 0.45 10.7 10.2 0.7 10.1 4.1 2.1 1 1 1 2 2 2 0 FlgN protein Nup54 PF13874.1 EDK38681.2 - 0.55 9.9 11.3 0.85 9.2 7.8 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 SlyX PF04102.7 EDK38681.2 - 0.82 10.0 14.4 0.88 9.9 4.8 2.8 1 1 0 2 2 2 0 SlyX SNARE PF05739.14 EDK38681.2 - 0.98 9.1 15.8 0.12 12.1 0.8 3.1 2 1 1 3 3 3 0 SNARE domain Mnd1 PF03962.10 EDK38681.2 - 1.2 8.7 7.0 1.8 8.1 4.9 1.2 1 0 0 1 1 1 0 Mnd1 family MscS_porin PF12795.2 EDK38681.2 - 1.5 8.1 16.4 2.2 7.5 11.4 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain APG6 PF04111.7 EDK38681.2 - 2 7.4 6.4 2.9 6.8 4.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Med9 PF07544.8 EDK38681.2 - 3.7 7.3 10.9 5 6.9 1.2 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ADIP PF11559.3 EDK38681.2 - 8.3 6.3 13.8 18 5.1 9.2 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding MpPF26 PF07666.6 EDK38682.2 - 0.0055 16.6 3.2 0.2 11.5 0.2 2.2 2 0 0 2 2 2 2 M penetrans paralogue family 26 DUF1616 PF07760.6 EDK38682.2 - 0.14 11.3 4.5 0.11 11.5 0.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1616) AhpC-TSA PF00578.16 EDK38683.1 - 2.1e-34 117.8 0.0 2.8e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EDK38683.1 - 1.9e-16 59.8 0.0 2.6e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 EDK38683.1 - 3.1e-13 49.1 0.3 6.5e-13 48.1 0.0 1.7 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin HIT PF01230.18 EDK38684.2 - 4.9e-23 81.4 0.1 6.8e-23 81.0 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EDK38684.2 - 1e-05 25.7 0.0 1.6e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EDK38684.2 - 0.1 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Med6 PF04934.9 EDK38685.2 - 5.7e-54 181.4 0.5 7.2e-54 181.1 0.3 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component Pro_isomerase PF00160.16 EDK38687.1 - 1.1e-41 142.6 0.2 1.4e-41 142.2 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IGR PF09597.5 EDK38688.1 - 6.1e-24 83.6 0.2 9.4e-24 83.0 0.1 1.3 1 0 0 1 1 1 1 IGR protein motif ABC_tran_2 PF12848.2 EDK38688.1 - 0.0071 16.1 2.2 0.087 12.6 1.5 2.1 1 1 0 1 1 1 1 ABC transporter Ligase_CoA PF00549.14 EDK38689.2 - 1.1e-24 86.8 0.0 1.7e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 EDK38689.2 - 1.3e-24 86.4 1.2 1.3e-24 86.4 0.8 2.0 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 EDK38689.2 - 2.1e-05 24.1 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 EDK38689.2 - 0.0004 20.5 0.1 0.001 19.1 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain Actin PF00022.14 EDK38690.2 - 6.6e-19 67.5 0.0 2.1e-12 46.2 0.0 3.9 3 1 0 3 3 3 2 Actin MreB_Mbl PF06723.8 EDK38690.2 - 0.00057 18.5 0.0 0.0075 14.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 EDK38690.2 - 0.1 12.4 0.0 0.44 10.3 0.0 2.2 2 0 0 2 2 2 0 Cell division protein FtsA CemA PF03040.9 EDK38690.2 - 0.35 10.4 2.4 0.72 9.4 1.7 1.4 1 0 0 1 1 1 0 CemA family Tim17 PF02466.14 EDK38692.2 - 2.3e-19 69.6 0.0 3.9e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family La PF05383.12 EDK38693.2 - 2.4e-18 65.6 0.4 5.7e-18 64.4 0.1 1.8 2 0 0 2 2 2 1 La domain HCO3_cotransp PF00955.16 EDK38694.2 - 0.00022 20.0 9.8 0.0021 16.8 3.8 2.1 1 1 1 2 2 2 2 HCO3- transporter family HCO3_cotransp PF00955.16 EDK38695.2 - 6.1e-42 143.9 8.2 2.7e-37 128.6 4.2 2.0 1 1 1 2 2 2 2 HCO3- transporter family HCO3_cotransp PF00955.16 EDK38696.2 - 8.3e-15 54.4 0.1 1.2e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 HCO3- transporter family HCO3_cotransp PF00955.16 EDK38697.2 - 4.9e-38 131.0 10.6 2.7e-37 128.6 4.4 2.0 1 1 1 2 2 2 2 HCO3- transporter family Asparaginase_2 PF01112.13 EDK38698.2 - 5.5e-16 58.1 0.0 4.1e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 Asparaginase Ribosomal_L24e PF01246.15 EDK38699.1 - 5.5e-34 115.8 0.4 5.5e-34 115.8 0.3 2.0 2 1 0 2 2 2 1 Ribosomal protein L24e PTS_IIA PF02255.11 EDK38699.1 - 3.9 7.3 6.5 6.9 6.6 4.5 1.4 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Ribosomal_L7Ae PF01248.21 EDK38700.1 - 2.6e-24 84.5 0.0 3e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DASH_Spc34 PF08657.5 EDK38701.2 - 1.3e-65 221.6 4.2 1.4e-65 221.5 2.9 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 TMPIT PF07851.8 EDK38701.2 - 0.11 11.6 2.0 0.15 11.1 1.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF641 PF04859.7 EDK38701.2 - 0.15 11.8 3.0 0.27 10.9 2.1 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Takusan PF04822.8 EDK38701.2 - 0.44 10.3 4.2 0.96 9.2 2.9 1.5 1 0 0 1 1 1 0 Takusan AAA_23 PF13476.1 EDK38701.2 - 0.86 9.8 6.7 1.7 8.9 4.6 1.3 1 1 0 1 1 1 0 AAA domain IncA PF04156.9 EDK38701.2 - 1 8.9 4.9 1.3 8.5 3.4 1.2 1 0 0 1 1 1 0 IncA protein Peptidase_M22 PF00814.20 EDK38702.1 - 2e-84 283.2 0.0 2.4e-84 283.0 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family DnaJ PF00226.26 EDK38703.2 - 1e-19 69.9 0.1 2e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.17 EDK38703.2 - 0.0035 16.9 0.0 0.0089 15.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.1 EDK38703.2 - 0.0045 16.5 0.8 0.0092 15.5 0.0 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4523) RRM_6 PF14259.1 EDK38703.2 - 0.0051 16.7 0.0 0.023 14.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF543 PF04418.7 EDK38704.1 - 6.5e-27 93.2 2.5 7.9e-27 93.0 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Voltage_CLC PF00654.15 EDK38705.2 - 7.7e-92 308.0 21.3 7.7e-92 308.0 14.7 1.9 2 0 0 2 2 2 1 Voltage gated chloride channel MT-A70 PF05063.9 EDK38706.2 - 1.2e-13 51.0 0.0 1.9e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 MT-A70 zf-Sec23_Sec24 PF04810.10 EDK38706.2 - 0.16 11.5 2.0 0.38 10.3 1.4 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Iso_dh PF00180.15 EDK38707.1 - 4.2e-72 242.9 0.0 5e-72 242.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF2543 PF10820.3 EDK38707.1 - 0.12 12.3 0.2 0.75 9.8 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2543) mRNA_triPase PF02940.10 EDK38708.2 - 2.7e-55 187.4 4.8 4.4e-55 186.7 3.3 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain CorC_HlyC PF03471.12 EDK38708.2 - 0.12 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Transporter associated domain ATP11 PF06644.6 EDK38708.2 - 1.7 8.0 7.4 0.34 10.3 1.2 2.1 2 0 0 2 2 2 0 ATP11 protein Glycos_transf_2 PF00535.21 EDK38709.2 - 2.1e-25 89.3 0.0 2.8e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EDK38709.2 - 2.9e-10 40.3 0.0 4.1e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EDK38709.2 - 0.0024 17.0 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 EDK38709.2 - 0.0031 17.8 0.0 0.0085 16.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7N PF13733.1 EDK38709.2 - 0.063 12.6 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 DUF4372 PF14294.1 EDK38710.2 - 0.094 12.6 1.4 0.24 11.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) Ribonuclease PF00545.15 EDK38710.2 - 0.12 12.4 1.2 0.26 11.3 0.8 1.5 1 0 0 1 1 1 0 ribonuclease Per1 PF04080.8 EDK38711.2 - 3.1e-86 289.1 15.0 4.4e-86 288.6 10.4 1.2 1 0 0 1 1 1 1 Per1-like DUF4282 PF14110.1 EDK38711.2 - 0.0091 16.1 0.1 0.0091 16.1 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4282) Apc5 PF12862.2 EDK38711.2 - 0.1 12.4 0.1 5.1 7.0 0.2 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF3317 PF11779.3 EDK38711.2 - 1.2 8.6 5.8 11 5.4 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3317) DUF2404 PF10296.4 EDK38713.2 - 5e-30 103.4 0.0 1.2e-29 102.2 0.0 1.7 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) PH_11 PF15413.1 EDK38713.2 - 6.8e-13 48.8 1.4 1.1e-12 48.1 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 EDK38713.2 - 8.1e-06 25.9 0.2 3.1e-05 24.1 0.1 2.0 1 0 0 1 1 1 1 PH domain PI3_PI4_kinase PF00454.22 EDK38714.2 - 2.1e-49 168.1 0.2 1.2e-48 165.6 0.1 2.5 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.8 EDK38714.2 - 2.9e-28 97.9 1.7 2.2e-27 95.1 1.2 2.8 1 0 0 1 1 1 1 UME (NUC010) domain FAT PF02259.18 EDK38714.2 - 4.3e-18 65.4 6.5 2e-16 59.9 5.1 2.7 2 1 0 2 2 2 1 FAT domain FATC PF02260.15 EDK38714.2 - 6.1e-15 54.3 0.1 1.3e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 FATC domain TPR_11 PF13414.1 EDK38714.2 - 0.0099 15.5 2.0 4.1 7.1 0.4 3.1 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.1 EDK38714.2 - 0.18 12.5 0.0 0.61 10.8 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PRMT5 PF05185.11 EDK38715.2 - 3.1e-56 191.1 0.1 3.8e-55 187.6 0.0 2.0 1 1 1 2 2 2 1 PRMT5 arginine-N-methyltransferase Methyltransf_26 PF13659.1 EDK38715.2 - 4.9e-06 26.5 0.0 1.9e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK38715.2 - 1.4e-05 25.6 0.0 4.9e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK38715.2 - 0.013 15.0 0.0 0.029 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 EDK38715.2 - 0.019 14.7 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EDK38715.2 - 0.16 11.3 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CKS PF01111.14 EDK38716.2 - 2.5e-33 113.7 0.1 3.7e-33 113.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF2867 PF11066.3 EDK38716.2 - 0.017 14.8 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) APC_15aa PF05972.6 EDK38716.2 - 0.084 12.8 0.7 16 5.7 0.1 2.6 2 0 0 2 2 2 0 APC 15 residue motif CWC25 PF12542.3 EDK38717.2 - 7e-16 58.4 0.7 7e-16 58.4 0.5 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing factor Cir_N PF10197.4 EDK38717.2 - 1.2e-13 50.7 15.0 1.2e-13 50.7 10.4 2.4 2 1 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR Cgr1 PF03879.9 EDK38717.2 - 0.0088 16.2 7.3 0.0088 16.2 5.1 2.4 2 1 0 2 2 2 1 Cgr1 family C1q PF00386.16 EDK38717.2 - 0.04 13.9 0.1 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 C1q domain IncA PF04156.9 EDK38717.2 - 0.73 9.4 8.0 1.4 8.4 5.6 1.4 1 0 0 1 1 1 0 IncA protein CTP_transf_1 PF01148.15 EDK38718.1 - 5.4e-30 104.9 19.1 6.6e-30 104.6 13.2 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family MFS_1 PF07690.11 EDK38719.2 - 1.4e-10 40.4 18.7 1.4e-10 40.4 13.0 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Mid1 PF12929.2 EDK38721.2 - 1e-150 502.2 14.9 1.7e-150 501.5 10.3 1.3 1 1 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 EDK38721.2 - 0.011 16.0 1.7 0.46 10.8 0.1 2.5 2 0 0 2 2 2 0 Fz domain Rep_fac_C PF08542.6 EDK38722.2 - 2.9e-16 59.2 0.0 6e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EDK38722.2 - 1.5e-11 44.2 0.1 3.2e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EDK38722.2 - 1.1e-05 25.6 0.2 1.8e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.8 EDK38722.2 - 0.00011 21.7 0.1 0.00019 21.0 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 EDK38722.2 - 0.012 14.2 0.2 0.019 13.6 0.1 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Prenyltransf PF01255.14 EDK38722.2 - 0.034 13.2 0.1 0.064 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative undecaprenyl diphosphate synthase DEAD PF00270.24 EDK38722.2 - 0.039 13.4 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK38722.2 - 0.055 13.6 0.1 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain Smr PF01713.16 EDK38723.2 - 2.2e-14 53.3 0.2 7.6e-14 51.6 0.0 2.1 2 0 0 2 2 2 1 Smr domain CUE PF02845.11 EDK38723.2 - 3.1e-10 39.3 2.5 8.6e-06 25.1 0.0 3.6 3 0 0 3 3 3 2 CUE domain Pkinase PF00069.20 EDK38724.2 - 2.3e-72 243.3 0.0 3.7e-72 242.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38724.2 - 1.4e-48 165.2 0.0 2.3e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 EDK38724.2 - 4.7e-20 71.7 0.2 4.1e-19 68.7 0.0 2.9 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 EDK38724.2 - 8.3e-05 21.6 0.0 0.00013 21.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK38724.2 - 0.017 14.8 0.0 0.25 11.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Hydrolase_like PF13242.1 EDK38725.1 - 6.2e-15 54.6 0.0 1.9e-13 49.8 0.0 2.9 2 1 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 EDK38725.1 - 1e-11 44.5 0.0 2.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase adh_short PF00106.20 EDK38727.1 - 3.2e-22 79.2 0.0 4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK38727.1 - 3.4e-17 63.0 0.1 3.9e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK38727.1 - 1.3e-12 47.7 0.0 1.6e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK38727.1 - 8.9e-06 25.2 0.1 1.8e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EDK38727.1 - 0.0028 17.6 0.1 0.0064 16.5 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 EDK38727.1 - 0.035 14.0 0.0 0.089 12.7 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.12 EDK38727.1 - 0.11 12.8 0.0 0.38 11.2 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Fcf1 PF04900.7 EDK38728.1 - 6.5e-40 135.3 0.2 1.3e-39 134.3 0.1 1.5 1 0 0 1 1 1 1 Fcf1 Metallophos PF00149.23 EDK38729.2 - 7.9e-06 25.3 0.2 1.6e-05 24.4 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EDK38729.2 - 0.00022 21.0 0.0 0.00047 20.0 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MCP_N PF05581.7 EDK38729.2 - 0.071 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Vibrio chemotaxis protein N terminus UBA PF00627.26 EDK38730.2 - 8.5e-10 38.1 0.1 2.2e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 EDK38730.2 - 0.001 18.5 1.2 0.0014 18.1 0.0 1.8 2 0 0 2 2 2 1 UBA-like domain CUE PF02845.11 EDK38730.2 - 0.0057 16.1 0.0 0.016 14.6 0.0 1.9 1 0 0 1 1 1 1 CUE domain Cullin_binding PF03556.10 EDK38730.2 - 0.2 11.8 1.7 0.35 11.0 0.2 2.1 2 0 0 2 2 2 0 Cullin binding tRNA-synt_1d PF00750.14 EDK38731.2 - 1.2e-96 323.6 4.1 1.5e-96 323.3 2.8 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 EDK38731.2 - 3.9e-29 101.0 0.0 2.3e-28 98.5 0.0 2.4 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 EDK38731.2 - 4.2e-06 27.2 0.1 1.3e-05 25.6 0.0 2.0 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain PINIT PF14324.1 EDK38732.2 - 4.2e-37 127.4 0.0 4.2e-37 127.4 0.0 6.5 3 1 1 7 7 7 1 PINIT domain zf-MIZ PF02891.15 EDK38732.2 - 3.5e-21 74.4 6.6 7.7e-21 73.3 4.6 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 EDK38732.2 - 3.3e-08 32.8 3.7 4.4e-08 32.4 0.4 2.3 2 0 0 2 2 2 1 SAP domain zf-Nse PF11789.3 EDK38732.2 - 8.5e-07 28.4 2.4 1.9e-06 27.2 1.7 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.1 EDK38732.2 - 0.057 13.0 2.7 0.1 12.2 1.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK38732.2 - 0.16 11.8 7.1 0.32 10.8 4.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EDK38732.2 - 0.19 11.7 6.6 0.36 10.9 4.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK38732.2 - 0.6 9.8 4.6 1.3 8.8 3.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 EDK38732.2 - 0.68 9.6 6.1 1.4 8.6 4.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK38732.2 - 1.1 9.1 5.8 2.1 8.2 4.0 1.5 1 0 0 1 1 1 0 Ring finger domain SHS2_Rpb7-N PF03876.12 EDK38733.2 - 1.7e-17 63.2 0.0 2.9e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 EDK38733.2 - 8.1e-15 54.6 0.1 1.3e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 EDK38733.2 - 0.08 13.1 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 RNA polymerase III subunit Rpc25 Ribosomal_L13 PF00572.13 EDK38734.2 - 1.4e-41 141.5 0.1 2.3e-41 140.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L13 Sif PF06767.6 EDK38734.2 - 0.085 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Sif protein RNA_pol_Rpb2_6 PF00562.23 EDK38735.2 - 1.3e-125 419.1 0.0 2.5e-125 418.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EDK38735.2 - 4.1e-67 225.0 0.1 6.7e-67 224.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EDK38735.2 - 1.3e-49 168.2 0.0 2.4e-49 167.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EDK38735.2 - 3.4e-31 107.3 0.1 7.7e-31 106.1 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 EDK38735.2 - 5.8e-28 96.5 0.4 1.2e-27 95.5 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 EDK38735.2 - 4.7e-23 80.9 0.3 1.1e-22 79.7 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_3 PF04565.11 EDK38735.2 - 5.9e-22 77.2 0.1 1.5e-21 75.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 Ribosomal_L23 PF00276.15 EDK38736.2 - 8.1e-19 67.3 0.0 1.6e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 TB2_DP1_HVA22 PF03134.14 EDK38737.2 - 7.3e-08 32.0 1.0 3.4e-07 29.9 0.8 1.9 2 0 0 2 2 2 1 TB2/DP1, HVA22 family ISN1 PF06437.6 EDK38738.2 - 1.1e-187 623.8 0.0 1.2e-187 623.6 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Ribosomal_S4e PF00900.15 EDK38739.1 - 1.8e-31 107.6 0.4 4.1e-31 106.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 EDK38739.1 - 8.6e-08 31.9 0.0 2.3e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.20 EDK38739.1 - 3.3e-07 29.6 0.0 6.2e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 EDK38739.1 - 3.4e-05 23.3 1.2 3.4e-05 23.3 0.8 3.5 4 0 0 4 4 4 1 KOW motif S4_2 PF13275.1 EDK38739.1 - 0.1 12.2 0.0 0.61 9.7 0.0 2.1 2 0 0 2 2 2 0 S4 domain CIA30 PF08547.7 EDK38740.2 - 4.4e-41 140.3 0.0 5.8e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Choline_transpo PF04515.7 EDK38741.2 - 1.1e-09 37.5 4.5 1.1e-09 37.5 3.1 2.3 2 0 0 2 2 2 2 Plasma-membrane choline transporter WBP-1 PF11669.3 EDK38741.2 - 0.071 13.1 0.2 0.071 13.1 0.1 2.3 2 1 1 3 3 3 0 WW domain-binding protein 1 Ndc1_Nup PF09531.5 EDK38741.2 - 0.28 9.5 14.4 0.43 8.9 10.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2585 PF10755.4 EDK38741.2 - 0.46 9.9 4.7 0.26 10.7 1.5 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2585) DUF3464 PF11947.3 EDK38741.2 - 1.4 8.3 3.3 3.3 7.1 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Choline_transpo PF04515.7 EDK38742.1 - 7.3e-57 192.6 6.8 8.2e-57 192.4 4.7 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter Metallophos_2 PF12850.2 EDK38743.2 - 1.4e-12 47.7 0.0 2.5e-12 46.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CagX PF03524.10 EDK38743.2 - 0.011 14.9 0.1 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Conjugal transfer protein SpoIIP PF07454.6 EDK38743.2 - 0.035 13.2 3.8 0.27 10.3 2.9 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF262 PF03235.9 EDK38743.2 - 0.04 13.8 1.7 0.068 13.1 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 Tim54 PF11711.3 EDK38743.2 - 0.043 12.4 7.0 0.064 11.8 4.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Tom37_C PF11801.3 EDK38743.2 - 0.044 13.6 0.4 0.072 12.9 0.3 1.4 1 0 0 1 1 1 0 Tom37 C-terminal domain Ycf1 PF05758.7 EDK38743.2 - 0.055 11.1 5.4 0.068 10.8 3.8 1.1 1 0 0 1 1 1 0 Ycf1 CPSF100_C PF13299.1 EDK38743.2 - 0.056 13.6 1.4 0.061 13.5 0.2 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.7 EDK38743.2 - 0.074 10.9 11.9 0.095 10.6 8.3 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.11 EDK38743.2 - 0.098 11.6 5.9 0.15 10.9 4.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Kei1 PF08552.6 EDK38743.2 - 0.11 12.1 0.2 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2722 PF10846.3 EDK38743.2 - 0.11 11.4 4.4 0.19 10.7 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Trypan_PARP PF05887.6 EDK38743.2 - 0.13 12.0 9.3 0.19 11.5 6.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CAF-1_p150 PF11600.3 EDK38743.2 - 0.59 9.4 28.1 0.9 8.8 19.4 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Vfa1 PF08432.5 EDK38743.2 - 0.72 9.8 12.6 1.2 9.1 8.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GOLD_2 PF13897.1 EDK38743.2 - 0.92 9.7 5.5 1.8 8.7 3.8 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Zip PF02535.17 EDK38743.2 - 0.96 8.3 2.5 1.3 7.9 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Nucleoplasmin PF03066.10 EDK38743.2 - 1.3 8.5 13.8 2.2 7.7 9.5 1.5 1 0 0 1 1 1 0 Nucleoplasmin Usp PF00582.21 EDK38743.2 - 1.3 9.2 5.8 2.6 8.2 3.5 1.8 2 0 0 2 2 2 0 Universal stress protein family TFIIF_alpha PF05793.7 EDK38743.2 - 1.3 7.3 19.9 1.7 6.9 13.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RRN3 PF05327.6 EDK38743.2 - 1.8 6.5 6.5 2.4 6.1 4.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.9 EDK38743.2 - 2.3 6.1 11.2 3.3 5.6 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.6 EDK38743.2 - 2.5 7.7 17.6 4 7.0 12.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4637 PF15470.1 EDK38743.2 - 2.6 7.6 10.9 3.9 7.0 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Radial_spoke PF04712.7 EDK38743.2 - 3.4 6.3 14.4 4.8 5.8 10.0 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein YqfQ PF14181.1 EDK38743.2 - 4.1 7.4 13.6 6.9 6.6 9.5 1.3 1 0 0 1 1 1 0 YqfQ-like protein VID27 PF08553.5 EDK38743.2 - 5.9 4.9 14.0 7.8 4.5 9.7 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein FAM176 PF14851.1 EDK38743.2 - 6 6.5 9.9 11 5.6 6.9 1.3 1 0 0 1 1 1 0 FAM176 family ATP-synt_E PF05680.7 EDK38743.2 - 6.5 6.7 9.6 11 6.0 6.6 1.3 1 0 0 1 1 1 0 ATP synthase E chain Daxx PF03344.10 EDK38743.2 - 7.2 4.9 20.2 11 4.3 14.0 1.2 1 0 0 1 1 1 0 Daxx Family NOT2_3_5 PF04153.13 EDK38744.2 - 5.4e-38 129.9 0.2 6.8e-38 129.5 0.1 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AAA_18 PF13238.1 EDK38745.1 - 7e-28 97.5 0.4 1.1e-27 96.8 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EDK38745.1 - 1e-13 52.1 0.7 3.6e-13 50.3 0.1 1.8 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 EDK38745.1 - 8e-05 22.8 0.0 0.00028 21.0 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.1 EDK38745.1 - 8.5e-05 22.5 0.0 0.0002 21.2 0.0 1.8 1 1 1 2 2 2 1 Cytidylate kinase-like family Thymidylate_kin PF02223.12 EDK38745.1 - 0.00029 20.2 0.1 0.083 12.2 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.1 EDK38745.1 - 0.00034 20.5 0.0 0.092 12.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 EDK38745.1 - 0.00042 20.3 0.0 0.0011 18.9 0.0 1.8 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.5 EDK38745.1 - 0.0011 18.2 0.0 0.0023 17.1 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.7 EDK38745.1 - 0.0016 18.1 0.0 0.0035 16.9 0.0 1.7 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.1 EDK38745.1 - 0.0021 18.0 0.0 0.0045 16.9 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EDK38745.1 - 0.0022 17.7 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EDK38745.1 - 0.0022 17.1 0.0 0.0048 16.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin RNA_helicase PF00910.17 EDK38745.1 - 0.0098 16.0 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 EDK38745.1 - 0.01 15.9 0.0 0.013 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EDK38745.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ADK PF00406.17 EDK38745.1 - 0.014 15.2 0.7 1.8 8.4 0.5 2.3 1 1 0 1 1 1 0 Adenylate kinase Glutaredoxin PF00462.19 EDK38745.1 - 0.026 14.5 0.0 0.084 12.8 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin NACHT PF05729.7 EDK38745.1 - 0.028 14.0 0.0 0.099 12.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Viral_helicase1 PF01443.13 EDK38745.1 - 0.048 13.1 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase tRNA_lig_kinase PF08303.6 EDK38745.1 - 0.071 12.9 0.1 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain PRK PF00485.13 EDK38745.1 - 0.11 12.0 0.0 0.29 10.6 0.0 1.7 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family Mg_chelatase PF01078.16 EDK38745.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.10 EDK38745.1 - 0.21 11.2 1.3 0.45 10.1 0.1 2.1 2 1 0 2 2 2 0 NTPase Heme_oxygenase PF01126.15 EDK38746.1 - 7.8e-27 94.1 0.9 1.4e-26 93.3 0.6 1.4 1 1 0 1 1 1 1 Heme oxygenase Ribosomal_S6 PF01250.12 EDK38746.1 - 0.042 13.6 0.1 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein S6 AA_permease PF00324.16 EDK38747.2 - 4.9e-122 407.6 35.5 5.7e-122 407.4 24.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK38747.2 - 9.4e-35 119.9 35.9 1.1e-34 119.7 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease PRELI PF04707.9 EDK38748.2 - 4.4e-38 130.3 0.1 5.3e-38 130.0 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family DUF3970 PF13113.1 EDK38749.1 - 0.12 12.0 0.2 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) Cwf_Cwc_15 PF04889.7 EDK38750.2 - 0.85 9.2 9.8 1.1 8.9 6.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Prefoldin_2 PF01920.15 EDK38751.2 - 1.8e-20 72.6 9.4 2.1e-20 72.4 6.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.12 EDK38751.2 - 0.0038 16.8 4.2 0.0045 16.6 2.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF3727 PF12527.3 EDK38751.2 - 0.0083 16.1 0.9 0.012 15.7 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3727) Occludin_ELL PF07303.8 EDK38751.2 - 0.048 14.4 4.7 0.36 11.5 0.6 2.1 2 0 0 2 2 2 0 Occludin homology domain Spc24 PF08286.6 EDK38751.2 - 0.05 13.2 8.5 0.2 11.3 0.9 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF1192 PF06698.6 EDK38751.2 - 0.06 13.1 0.8 0.06 13.1 0.6 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF1192) Lge1 PF11488.3 EDK38751.2 - 0.083 13.0 4.5 0.12 12.6 0.3 2.3 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 CENP-F_leu_zip PF10473.4 EDK38751.2 - 0.14 11.9 10.9 0.32 10.8 1.5 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AF0941-like PF14591.1 EDK38751.2 - 0.18 11.8 3.7 0.43 10.6 2.4 1.7 1 1 0 1 1 1 0 AF0941-like FliJ PF02050.11 EDK38751.2 - 0.37 10.8 8.0 2.1 8.4 0.6 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein Prefoldin_3 PF13758.1 EDK38751.2 - 0.53 10.0 4.4 3 7.6 3.1 2.1 1 1 0 1 1 1 0 Prefoldin subunit Streptin-Immun PF11083.3 EDK38751.2 - 0.83 9.6 5.3 0.28 11.2 0.5 2.1 2 1 0 2 2 2 0 Lantibiotic streptin immunity protein IncA PF04156.9 EDK38751.2 - 1.2 8.7 9.5 4.3 6.8 6.6 1.7 1 1 0 1 1 1 0 IncA protein THOC7 PF05615.8 EDK38751.2 - 1.3 9.3 7.6 1.6 9.0 1.0 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 DUF1374 PF07118.6 EDK38751.2 - 1.3 9.1 5.8 0.49 10.5 1.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1374) Atg14 PF10186.4 EDK38751.2 - 1.3 7.8 7.3 2.9 6.7 4.8 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4200 PF13863.1 EDK38751.2 - 2.2 8.2 9.7 4.8 7.1 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) FlaC_arch PF05377.6 EDK38751.2 - 2.4 8.1 6.3 3.5 7.5 0.5 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.5 EDK38751.2 - 2.9 8.0 6.0 2 8.5 0.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.2 EDK38751.2 - 4 7.2 9.9 28 4.5 6.9 2.0 1 1 0 1 1 1 0 Tropomyosin like COQ9 PF08511.6 EDK38752.2 - 2.3e-27 94.3 0.1 5.2e-27 93.1 0.0 1.6 2 0 0 2 2 2 1 COQ9 POC1 PF10450.4 EDK38753.1 - 2.6e-05 23.1 0.0 3.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 POC1 chaperone Mpv17_PMP22 PF04117.7 EDK38754.2 - 1.9e-23 81.8 5.1 7.7e-23 79.9 1.7 3.0 3 0 0 3 3 3 1 Mpv17 / PMP22 family Tachylectin PF14517.1 EDK38754.2 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Tachylectin NADH_u_ox_C PF12853.2 EDK38755.2 - 8.1e-42 140.8 0.6 1.1e-41 140.4 0.4 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit NADH-u_ox-rdase PF10785.4 EDK38755.2 - 6.1e-32 109.7 0.0 9e-32 109.1 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit CLASP_N PF12348.3 EDK38756.2 - 4.7e-12 45.7 0.8 1.7e-10 40.6 0.4 2.9 3 0 0 3 3 3 1 CLASP N terminal HEAT PF02985.17 EDK38756.2 - 1.2e-06 28.0 5.3 2.5 8.4 0.1 6.1 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.2 EDK38756.2 - 0.0039 17.0 0.8 0.05 13.4 0.5 2.4 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 ETF PF01012.16 EDK38757.1 - 5.5e-35 120.5 0.1 7.2e-35 120.1 0.1 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain MOZART2 PF12926.2 EDK38757.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated AAA_14 PF13173.1 EDK38758.2 - 0.0054 16.6 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK38758.2 - 0.0063 17.3 0.0 0.012 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EDK38758.2 - 0.031 14.4 0.0 0.061 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase KAP_NTPase PF07693.9 EDK38758.2 - 0.037 13.0 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_16 PF13191.1 EDK38758.2 - 0.064 13.2 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Adeno_IVa2 PF02456.10 EDK38758.2 - 0.08 11.5 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Zeta_toxin PF06414.7 EDK38758.2 - 0.081 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AA_permease PF00324.16 EDK38759.2 - 1.3e-137 459.0 33.9 1.5e-137 458.8 23.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK38759.2 - 3.2e-41 141.2 35.4 4.1e-41 140.9 24.5 1.0 1 0 0 1 1 1 1 Amino acid permease MULE PF10551.4 EDK38759.2 - 0.15 12.2 0.0 24 5.1 0.0 2.5 2 0 0 2 2 2 0 MULE transposase domain DUF1772 PF08592.6 EDK38759.2 - 5 6.8 9.4 1.4 8.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) SlyX PF04102.7 EDK38760.2 - 0.00029 21.1 1.4 0.037 14.3 0.0 2.7 2 1 0 2 2 2 1 SlyX Mer2 PF09074.5 EDK38760.2 - 0.0075 16.2 2.0 0.01 15.7 0.8 1.8 1 1 1 2 2 2 1 Mer2 FlaC_arch PF05377.6 EDK38760.2 - 0.13 12.2 0.3 17 5.3 0.0 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4191 PF13829.1 EDK38760.2 - 0.14 11.2 0.1 0.37 9.8 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) Syntaxin PF00804.20 EDK38760.2 - 2.2 8.5 6.1 21 5.3 4.0 2.3 1 1 0 1 1 1 0 Syntaxin LSM PF01423.17 EDK38761.1 - 7.7e-10 38.1 0.1 1.8e-09 37.0 0.0 1.6 2 0 0 2 2 2 1 LSM domain Aldolase_II PF00596.16 EDK38762.2 - 1.4e-40 138.8 0.0 1.8e-40 138.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Nop PF01798.13 EDK38763.2 - 5.1e-60 201.1 0.8 1.2e-59 199.9 0.6 1.7 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EDK38763.2 - 5.1e-26 90.2 0.0 1.2e-25 89.0 0.0 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EDK38763.2 - 1.8e-18 66.4 2.0 1.8e-18 66.4 1.4 2.8 2 1 0 2 2 2 1 NOP5NT (NUC127) domain GAGA_bind PF06217.7 EDK38763.2 - 0.15 11.9 21.4 0.26 11.1 14.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Dna2 PF08696.6 EDK38764.2 - 1.9e-67 226.6 0.1 3.6e-67 225.7 0.1 1.5 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 EDK38764.2 - 9.6e-47 158.9 0.2 7.1e-46 156.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 EDK38764.2 - 1.4e-37 129.5 0.4 1.7e-17 63.7 0.0 2.7 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.1 EDK38764.2 - 4.6e-11 42.6 0.0 1.8e-10 40.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK38764.2 - 4.8e-09 35.8 0.0 1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 EDK38764.2 - 1.8e-07 30.9 0.7 0.076 12.5 0.1 4.0 2 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.12 EDK38764.2 - 2.4e-07 30.8 1.6 3.9e-06 26.8 0.2 2.7 3 0 0 3 3 2 1 Domain of unknown function DUF83 UvrD-helicase PF00580.16 EDK38764.2 - 7.8e-06 25.4 0.9 3.1e-05 23.4 0.0 2.5 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.1 EDK38764.2 - 0.00022 21.2 0.0 0.00079 19.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.9 EDK38764.2 - 0.00059 19.5 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 Helicase MobB PF03205.9 EDK38764.2 - 0.001 18.7 0.2 0.0029 17.3 0.1 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 EDK38764.2 - 0.002 18.4 0.1 0.0055 17.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EDK38764.2 - 0.0036 16.7 0.1 0.017 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EDK38764.2 - 0.0042 17.5 0.2 0.035 14.5 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein PIF1 PF05970.9 EDK38764.2 - 0.0055 15.7 0.4 0.17 10.7 0.1 2.9 4 0 0 4 4 3 1 PIF1-like helicase DUF2075 PF09848.4 EDK38764.2 - 0.0059 15.6 0.0 0.014 14.3 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.17 EDK38764.2 - 0.0082 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ArgK PF03308.11 EDK38764.2 - 0.011 14.5 0.1 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein PhoH PF02562.11 EDK38764.2 - 0.018 14.2 0.0 0.093 11.9 0.0 2.1 1 1 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.1 EDK38764.2 - 0.026 14.6 0.2 0.14 12.2 0.0 2.4 3 0 0 3 3 1 0 AAA domain FtsK_SpoIIIE PF01580.13 EDK38764.2 - 0.042 13.3 0.1 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 EDK38764.2 - 0.048 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.24 EDK38764.2 - 0.058 13.5 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 EDK38764.2 - 0.078 12.6 0.2 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 NTPase Diphthamide_syn PF01866.12 EDK38764.2 - 0.099 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Putative diphthamide synthesis protein AAA_33 PF13671.1 EDK38764.2 - 0.1 12.5 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.1 EDK38764.2 - 0.1 12.7 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Sel1 PF08238.7 EDK38765.2 - 2.8e-26 91.3 19.9 0.0018 18.8 0.1 10.1 10 0 0 10 10 10 7 Sel1 repeat TPR_19 PF14559.1 EDK38765.2 - 0.0035 17.6 6.2 3.4 8.0 0.1 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF2615 PF11027.3 EDK38765.2 - 0.071 13.0 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) TPR_16 PF13432.1 EDK38765.2 - 1.7 9.4 15.1 7.9 7.2 0.0 6.4 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.1 EDK38765.2 - 5 7.1 7.3 12 6.0 0.0 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat V_ATPase_I PF01496.14 EDK38766.2 - 1.4e-252 839.9 12.8 5.8e-202 672.5 10.0 2.1 2 0 0 2 2 2 2 V-type ATPase 116kDa subunit family Dor1 PF04124.7 EDK38766.2 - 0.058 11.8 0.1 0.14 10.6 0.0 1.5 1 0 0 1 1 1 0 Dor1-like family HOOK PF05622.7 EDK38766.2 - 0.38 8.5 0.1 0.57 7.9 0.1 1.1 1 0 0 1 1 1 0 HOOK protein GCR1_C PF12550.3 EDK38767.2 - 0.017 14.9 0.9 0.06 13.2 0.6 2.0 1 1 0 1 1 1 0 Transcriptional activator of glycolytic enzymes HLH PF00010.21 EDK38768.2 - 1.6e-18 66.1 1.4 1.2e-16 60.1 0.1 3.2 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain DUF2014 PF09427.5 EDK38768.2 - 0.00018 20.7 0.0 0.00035 19.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) GIDA PF01134.17 EDK38768.2 - 0.081 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A zf-RING_2 PF13639.1 EDK38769.2 - 2.1e-10 40.2 7.6 4.8e-10 39.1 5.3 1.6 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 EDK38769.2 - 3.2e-09 36.7 4.9 6.6e-09 35.7 3.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK38769.2 - 1.5e-07 30.9 4.9 2.9e-07 30.1 3.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EDK38769.2 - 1.2e-06 28.0 7.2 2.4e-06 27.1 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK38769.2 - 4.6e-06 26.1 4.0 1e-05 25.1 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK38769.2 - 0.00013 21.9 3.8 0.00013 21.9 2.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK38769.2 - 0.0011 18.7 2.1 0.0022 17.7 1.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 EDK38769.2 - 0.003 17.5 2.4 0.0077 16.1 1.7 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain DUF2921 PF11145.3 EDK38769.2 - 0.0073 14.0 0.1 0.012 13.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2921) zf-RING_UBOX PF13445.1 EDK38769.2 - 0.0081 15.8 1.9 0.024 14.3 1.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 EDK38769.2 - 0.039 13.7 0.4 0.091 12.5 0.3 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.2 EDK38769.2 - 1.6 8.8 5.7 4.6 7.3 4.0 1.9 1 1 0 1 1 1 0 RING-variant domain DUF3246 PF11596.3 EDK38770.2 - 2.9e-56 190.4 55.2 2.9e-56 190.4 38.3 13.0 7 4 4 11 11 11 2 Protein of unknown function (DUF3246) COQ7 PF03232.8 EDK38771.2 - 0.027 13.9 0.2 0.14 11.6 0.1 2.1 1 1 1 2 2 2 0 Ubiquinone biosynthesis protein COQ7 DUF445 PF04286.7 EDK38771.2 - 0.07 12.6 11.2 0.041 13.4 5.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF445) Complex1_LYR PF05347.10 EDK38772.1 - 2.6e-08 33.5 0.0 4.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EDK38772.1 - 2.5e-06 27.5 0.0 5.4e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 EDK38772.1 - 8.8e-06 26.1 0.0 1.1e-05 25.8 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like SAGA-Tad1 PF12767.2 EDK38772.1 - 0.03 13.9 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Glyco_transf_15 PF01793.11 EDK38773.2 - 4.1e-123 410.5 13.0 5.4e-123 410.1 9.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GLTP PF08718.6 EDK38774.1 - 1.1e-43 148.8 0.0 1.8e-43 148.1 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) YycI PF09648.5 EDK38775.2 - 0.026 14.0 3.0 0.17 11.2 1.5 2.2 2 0 0 2 2 2 0 YycH protein DUF3849 PF12960.2 EDK38775.2 - 0.12 12.3 1.3 0.55 10.1 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3849) Glyco_hydro_3 PF00933.16 EDK38776.2 - 1.3e-80 270.5 0.0 2e-80 270.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EDK38776.2 - 4.7e-67 225.8 0.0 1.7e-66 223.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EDK38776.2 - 9.8e-24 83.0 0.1 2e-23 82.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.7 EDK38776.2 - 5e-12 45.6 0.0 9.2e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 PA14 domain DUF2841 PF11001.3 EDK38777.2 - 4.4e-39 133.2 2.5 9.1e-39 132.1 1.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Nop PF01798.13 EDK38779.2 - 3.6e-59 198.3 0.1 7.7e-59 197.2 0.1 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EDK38779.2 - 1.4e-26 91.9 0.2 3.3e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 EDK38779.2 - 4.5e-23 81.1 0.5 4.5e-23 81.1 0.3 3.0 2 1 0 2 2 2 1 NOP5NT (NUC127) domain GAGA_bind PF06217.7 EDK38779.2 - 0.34 10.8 18.2 0.52 10.2 12.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.12 EDK38779.2 - 0.51 10.1 13.2 0.86 9.3 9.2 1.4 1 0 0 1 1 1 0 DDHD domain MIP-T3 PF10243.4 EDK38779.2 - 3.5 5.9 41.7 4.7 5.5 28.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1510 PF07423.6 EDK38779.2 - 4.9 6.4 33.8 8.5 5.6 23.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) RR_TM4-6 PF06459.7 EDK38779.2 - 7.5 6.3 25.0 6.8 6.4 16.4 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Fungal_trans_2 PF11951.3 EDK38780.2 - 5.2e-77 259.0 1.3 7.6e-77 258.4 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38780.2 - 2.5e-07 30.4 9.8 4.5e-07 29.6 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AflR PF08493.5 EDK38780.2 - 8.8 5.2 14.7 8 5.4 0.4 2.3 2 0 0 2 2 2 0 Aflatoxin regulatory protein UQ_con PF00179.21 EDK38781.1 - 2.8e-51 172.6 0.0 3.2e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK38781.1 - 5.9e-05 22.8 0.0 7.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EDK38781.1 - 0.00037 20.3 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 EDK38781.1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Bromodomain PF00439.20 EDK38782.2 - 4.1e-19 68.2 0.0 1.6e-18 66.3 0.0 2.0 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.8 EDK38783.2 - 3.4e-08 33.0 0.2 1.5e-07 31.0 0.0 2.2 3 0 0 3 3 3 1 Bromodomain associated RCC1 PF00415.13 EDK38784.2 - 3.8e-12 46.2 0.1 0.00025 21.1 0.0 4.8 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 EDK38784.2 - 5.1e-10 39.3 0.4 0.00014 21.8 0.0 2.8 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.2 EDK38784.2 - 1.2e-05 25.6 0.1 2.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RCC1_2 PF13540.1 EDK38784.2 - 1.3e-05 24.6 0.7 0.00015 21.2 0.0 3.2 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.1 EDK38784.2 - 0.001 19.5 1.3 0.0033 17.9 0.9 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 EDK38784.2 - 0.0018 17.9 1.3 2.6 8.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 EDK38784.2 - 0.0079 16.3 3.2 0.33 11.3 0.1 3.1 3 0 0 3 3 3 1 Ankyrin repeat zf-Mss51 PF13824.1 EDK38786.2 - 6.9e-21 73.8 0.6 1.4e-20 72.8 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.6 EDK38786.2 - 0.02 14.4 0.0 0.059 12.9 0.0 1.8 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain PRKCSH PF07915.8 EDK38787.2 - 1.9e-21 76.6 1.5 1.7e-20 73.6 0.6 2.7 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein SepZ PF06066.6 EDK38788.1 - 0.015 15.2 0.0 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 SepZ CAP18_C PF12153.3 EDK38788.1 - 0.042 13.5 0.9 0.057 13.0 0.6 1.2 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) Baculo_PEP_C PF04513.7 EDK38788.1 - 0.074 12.8 0.2 0.098 12.4 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4376 PF14301.1 EDK38788.1 - 0.085 12.9 0.1 0.1 12.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4376) DUF2505 PF10698.4 EDK38788.1 - 0.14 11.6 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) DUF382 PF04037.8 EDK38789.2 - 1.4e-54 183.3 0.3 3.4e-54 182.1 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.11 EDK38789.2 - 2e-18 65.4 0.5 3.6e-18 64.6 0.4 1.4 1 0 0 1 1 1 1 PSP Zn_clus PF00172.13 EDK38790.2 - 3.9e-05 23.4 8.1 7.7e-05 22.5 5.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Molybdopterin PF00384.17 EDK38791.2 - 3.6e-68 230.2 0.0 1.1e-65 222.0 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.1 EDK38791.2 - 7.9e-20 70.4 0.4 1.9e-19 69.2 0.2 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.4 EDK38791.2 - 2.4e-17 61.8 0.3 6.1e-17 60.5 0.2 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF1982 PF09326.6 EDK38791.2 - 5.7e-15 55.1 0.0 1.6e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) Fer2 PF00111.22 EDK38791.2 - 1.3e-08 34.4 0.3 1.3e-08 34.4 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.17 EDK38791.2 - 0.01 15.5 0.1 0.2 11.3 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.22 EDK38791.2 - 0.097 12.3 1.0 3 7.5 0.2 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.6 EDK38791.2 - 0.17 11.7 1.8 1.9 8.4 1.3 2.4 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster DUF4246 PF14033.1 EDK38792.2 - 1.7e-140 469.0 3.5 2.8e-140 468.3 1.2 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF4246) DUF2034 PF10356.4 EDK38794.2 - 8.2e-50 168.5 0.0 1.1e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 EDK38794.2 - 1.3e-05 24.9 0.0 0.0013 18.4 0.0 2.4 2 1 0 2 2 2 2 Restriction endonuclease YHYH PF14240.1 EDK38794.2 - 0.096 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 YHYH protein Glyco_hydro_18 PF00704.23 EDK38795.2 - 8.1e-25 87.9 4.1 9.7e-23 81.1 0.8 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 NAD_binding_5 PF07994.7 EDK38796.1 - 2.5e-116 388.3 0.3 2.9e-116 388.0 0.2 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 EDK38796.1 - 2.5e-44 149.6 0.9 6.3e-44 148.3 0.1 2.1 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase AMP-binding PF00501.23 EDK38797.2 - 3.4e-73 246.4 0.0 5.2e-73 245.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EDK38797.2 - 0.13 13.2 0.0 0.31 12.0 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Asparaginase PF00710.15 EDK38798.2 - 1.3e-72 244.3 0.0 1.6e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Asparaginase Abhydrolase_6 PF12697.2 EDK38799.2 - 9.7e-18 64.8 0.1 1.2e-17 64.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK38799.2 - 4.4e-05 23.2 0.1 5.5e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK38799.2 - 0.038 13.5 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.15 EDK38799.2 - 0.061 12.7 0.1 0.1 11.9 0.0 1.5 2 0 0 2 2 2 0 Putative esterase CPSase_L_D2 PF02786.12 EDK38801.2 - 7.8e-56 188.6 0.0 1.2e-55 188.1 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EDK38801.2 - 1.6e-36 124.7 0.1 2.8e-36 123.9 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 EDK38801.2 - 4.5e-17 62.3 0.0 9.5e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EDK38801.2 - 7.1e-14 51.2 0.0 5.2e-13 48.4 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 EDK38801.2 - 2.2e-12 46.7 0.0 3.6e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_carb_C PF02785.14 EDK38801.2 - 1.3e-07 31.5 0.0 6.7e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.17 EDK38801.2 - 3.3e-06 26.5 0.0 5.7e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EDK38801.2 - 0.0015 18.0 0.0 0.0072 15.8 0.0 2.0 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EDK38801.2 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 EDK38801.2 - 0.048 12.8 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain LamB_YcsF PF03746.11 EDK38802.2 - 9.2e-56 188.6 0.0 1.2e-55 188.2 0.0 1.1 1 0 0 1 1 1 1 LamB/YcsF family DUF2207 PF09972.4 EDK38805.1 - 0.00091 17.9 0.2 0.0011 17.6 0.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Peptidase_M50 PF02163.17 EDK38805.1 - 0.031 13.2 0.2 0.04 12.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M50 DUF4153 PF13687.1 EDK38805.1 - 0.11 11.9 5.8 0.036 13.5 2.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4153) RDD PF06271.7 EDK38805.1 - 0.91 9.4 10.9 0.096 12.5 3.8 1.9 2 0 0 2 2 2 0 RDD family Aldedh PF00171.17 EDK38806.1 - 3.8e-164 546.4 0.3 4.3e-164 546.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EDK38806.1 - 8.1e-05 21.9 0.1 0.022 14.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) LuxC PF05893.9 EDK38806.1 - 0.00061 18.6 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) COX6B PF02297.12 EDK38807.1 - 8.3e-23 80.2 6.3 1.1e-22 79.8 4.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 EDK38807.1 - 0.1 12.6 1.6 1.5 8.9 1.1 2.3 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 EDK38807.1 - 3.9 7.3 6.7 29 4.5 0.3 2.9 1 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like TRAPPC9-Trs120 PF08626.6 EDK38808.2 - 1.6e-277 923.4 3.7 1.9e-277 923.1 2.6 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Proteasome PF00227.21 EDK38809.2 - 3.4e-48 163.4 0.1 4.1e-48 163.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 EDK38809.2 - 3e-12 45.5 0.2 7.2e-12 44.3 0.1 1.7 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Aha1_N PF09229.6 EDK38810.2 - 1e-41 141.9 0.0 1.6e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 EDK38810.2 - 1.6e-16 60.5 0.0 2.9e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Serglycin PF04360.7 EDK38810.2 - 0.014 15.1 1.4 0.03 14.0 1.0 1.6 1 0 0 1 1 1 0 Serglycin TFIIF_alpha PF05793.7 EDK38810.2 - 0.39 9.0 5.1 0.51 8.6 3.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AF-4 PF05110.8 EDK38810.2 - 1.4 6.6 12.2 1.8 6.2 8.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein ADH_zinc_N PF00107.21 EDK38811.1 - 2.5e-18 65.8 0.2 4e-18 65.2 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK38811.1 - 0.0002 22.2 0.0 0.00048 21.0 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Pyr_redox_3 PF13738.1 EDK38811.1 - 0.015 15.4 0.1 0.033 14.2 0.1 1.5 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK38811.1 - 0.021 14.2 0.1 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.1 EDK38811.1 - 0.045 14.0 0.1 0.082 13.1 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding HycI PF01750.13 EDK38811.1 - 0.074 12.5 0.1 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase maturation protease TrkA_N PF02254.13 EDK38811.1 - 0.079 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Iso_dh PF00180.15 EDK38812.1 - 3.5e-96 322.1 0.0 4.3e-96 321.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF4591 PF15261.1 EDK38812.1 - 0.15 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) Formyl_trans_N PF00551.14 EDK38813.1 - 1.4e-45 155.1 0.1 1.6e-45 154.8 0.1 1.0 1 0 0 1 1 1 1 Formyl transferase MannoseP_isomer PF01050.13 EDK38813.1 - 0.075 12.6 0.4 0.16 11.5 0.2 1.6 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase GTP_EFTU PF00009.22 EDK38814.1 - 7.7e-63 211.3 0.1 1.1e-62 210.8 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EDK38814.1 - 7.9e-38 128.7 0.0 2.9e-37 126.8 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 EDK38814.1 - 8.7e-21 73.5 0.0 2.2e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EDK38814.1 - 4.3e-14 52.3 2.3 8.1e-14 51.4 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 EFG_II PF14492.1 EDK38814.1 - 5.1e-14 51.8 0.0 1.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 EDK38814.1 - 2.8e-05 24.0 0.2 7e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1279 PF06916.8 EDK38815.2 - 0.0064 16.7 1.0 1.3 9.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1279) MLANA PF14991.1 EDK38815.2 - 0.034 14.1 0.1 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein melan-A Cu_amine_oxid PF01179.15 EDK38816.2 - 2e-163 543.9 0.0 2.5e-163 543.6 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.11 EDK38816.2 - 6.1e-25 87.2 0.1 1.7e-24 85.8 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.11 EDK38816.2 - 3.7e-19 68.5 0.0 8.1e-19 67.4 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain RNA_Me_trans PF04252.8 EDK38817.1 - 4.5e-61 205.6 0.2 5.4e-61 205.4 0.1 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase tRNA_m1G_MT PF01746.16 EDK38817.1 - 0.0084 15.7 0.0 0.024 14.2 0.0 1.7 1 1 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase DDHD PF02862.12 EDK38818.2 - 1.1e-27 97.2 5.0 1.9e-27 96.5 0.0 2.6 2 1 0 2 2 2 1 DDHD domain DUF2305 PF10230.4 EDK38818.2 - 0.019 14.3 0.0 0.044 13.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Lipase_3 PF01764.20 EDK38818.2 - 0.04 13.5 0.0 0.093 12.3 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.2 EDK38818.2 - 0.064 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.9 EDK38818.2 - 0.073 12.3 0.2 3.1 7.0 0.0 2.6 3 0 0 3 3 3 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 EDK38818.2 - 0.085 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 EDK38818.2 - 0.096 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein LCCL PF03815.14 EDK38819.2 - 8.8e-07 28.8 0.1 1.9e-06 27.7 0.1 1.6 1 1 0 1 1 1 1 LCCL domain Ribonuc_red_lgC PF02867.10 EDK38820.2 - 1.5e-218 726.7 0.0 2.7e-218 725.9 0.0 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EDK38820.2 - 3e-23 81.3 0.0 8.6e-23 79.9 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 EDK38820.2 - 1.3e-15 57.5 0.5 3.7e-15 56.1 0.1 2.1 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 EDK38820.2 - 0.0097 14.0 0.0 0.015 13.3 0.0 1.3 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase PRP3 PF08572.5 EDK38821.2 - 8.7e-60 201.8 13.0 8.7e-60 201.8 9.0 1.5 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 EDK38821.2 - 4.1e-39 133.1 2.6 5e-39 132.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) HECT PF00632.20 EDK38822.2 - 1.9e-97 326.2 0.1 3.4e-97 325.4 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 EDK38822.2 - 1.5e-65 221.6 3.0 3.7e-65 220.4 2.1 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.7 EDK38822.2 - 2.4e-47 161.5 0.0 5.9e-47 160.2 0.0 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF4414 PF14377.1 EDK38822.2 - 9.7e-18 64.0 2.1 9.7e-18 64.0 1.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4414) 4HBT_2 PF13279.1 EDK38823.2 - 4.1e-08 33.6 0.1 6.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily zf-H2C2_2 PF13465.1 EDK38824.2 - 0.046 14.0 5.3 0.046 14.0 3.7 4.5 3 2 1 4 4 4 0 Zinc-finger double domain zf-C2H2 PF00096.21 EDK38824.2 - 0.12 12.7 25.2 0.13 12.6 4.4 4.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 EDK38824.2 - 0.28 11.1 16.4 0.98 9.4 1.8 3.9 3 1 0 3 3 3 0 C2H2-type zinc finger zf-DBF PF07535.7 EDK38824.2 - 1.6 8.4 6.1 8.8 6.0 1.1 2.7 3 0 0 3 3 3 0 DBF zinc finger zf-C2H2_4 PF13894.1 EDK38824.2 - 4.7 7.7 31.1 4.9 7.7 0.1 4.9 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK38824.2 - 7.3 6.8 11.9 1.3 9.2 0.2 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.9 EDK38824.2 - 8.4 6.1 11.5 9.1 6.0 0.2 3.5 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif C1_4 PF07975.7 EDK38824.2 - 9.2 6.3 10.9 2.4 8.2 1.2 2.9 3 0 0 3 3 3 0 TFIIH C1-like domain ELO PF01151.13 EDK38825.2 - 7.3e-60 202.3 26.5 8.7e-60 202.1 18.4 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family OAD_gamma PF04277.8 EDK38825.2 - 0.23 11.8 0.0 0.23 11.8 0.0 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain CNH PF00780.17 EDK38826.2 - 1.7e-75 254.0 0.1 4.2e-75 252.7 0.0 1.7 2 0 0 2 2 2 1 CNH domain RhoGEF PF00621.15 EDK38826.2 - 1e-37 129.7 3.5 3e-37 128.2 2.4 1.8 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.1 EDK38826.2 - 7.7e-25 87.4 0.8 7.7e-25 87.4 0.5 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain DEP PF00610.16 EDK38826.2 - 2e-11 43.4 0.0 5e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) P21-Arc PF04062.9 EDK38827.2 - 6.4e-82 273.5 0.0 7.2e-82 273.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit ICMT PF04140.9 EDK38828.2 - 3.4e-16 59.2 2.4 8e-16 58.0 1.6 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EDK38828.2 - 1.9e-13 50.4 3.2 1.9e-13 50.4 2.2 2.3 2 0 0 2 2 2 1 Phospholipid methyltransferase NnrU PF07298.6 EDK38828.2 - 0.0025 17.2 7.6 0.0044 16.4 5.3 1.4 1 1 0 1 1 1 1 NnrU protein ICMT PF04140.9 EDK38829.2 - 1.7e-23 82.5 0.1 3.6e-23 81.5 0.1 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 EDK38829.2 - 1.7e-13 50.5 0.4 1.7e-13 50.5 0.3 1.9 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 EDK38829.2 - 0.00027 20.2 0.3 0.00027 20.2 0.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) NnrU PF07298.6 EDK38829.2 - 0.011 15.1 0.4 0.024 14.0 0.2 1.8 1 1 1 2 2 2 0 NnrU protein NfeD PF01957.13 EDK38829.2 - 0.065 13.3 1.2 0.16 12.1 0.3 1.9 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF1049 PF06305.6 EDK38829.2 - 0.62 9.5 0.0 0.62 9.5 0.0 2.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1049) FA_desaturase PF00487.19 EDK38830.2 - 5.3e-21 75.2 17.2 9.5e-21 74.3 11.9 1.4 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EDK38830.2 - 4e-05 23.6 0.0 7.5e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Mito_carr PF00153.22 EDK38831.2 - 9.2e-31 105.4 9.1 6.2e-14 51.4 0.0 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein TPT PF03151.11 EDK38832.2 - 3.5e-28 98.1 6.5 3.5e-28 98.1 4.5 3.0 2 1 1 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 EDK38832.2 - 1.6e-10 40.4 17.9 2.2e-10 39.9 12.4 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 EDK38832.2 - 5.7e-09 36.0 23.3 1e-07 32.0 2.5 3.0 2 1 0 2 2 2 2 EamA-like transporter family DUF3611 PF12263.3 EDK38832.2 - 0.051 12.9 0.0 0.051 12.9 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3611) Na_H_Exchanger PF00999.16 EDK38833.2 - 1.4e-64 217.9 37.8 1.9e-64 217.6 26.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Ndc1_Nup PF09531.5 EDK38834.2 - 7.7e-138 460.5 19.9 8.6e-138 460.3 13.8 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Spo0A_C PF08769.6 EDK38835.2 - 0.032 14.0 0.1 0.17 11.7 0.1 2.0 2 1 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal MRP-S26 PF14943.1 EDK38835.2 - 3.2 7.2 25.6 0.024 14.1 3.7 2.4 1 1 1 2 2 2 0 Mitochondrial ribosome subunit S26 ERCC4 PF02732.10 EDK38836.2 - 1.4e-23 83.2 0.1 3.4e-23 81.9 0.1 1.7 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 EDK38836.2 - 0.00018 21.6 0.0 0.0034 17.5 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain HTH_45 PF14947.1 EDK38836.2 - 0.02 14.6 0.0 0.074 12.8 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix LSM PF01423.17 EDK38837.2 - 3.6e-17 61.6 0.1 4.4e-17 61.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain PAD PF03068.10 EDK38837.2 - 0.094 11.1 0.0 0.096 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Rad52_Rad22 PF04098.10 EDK38839.2 - 4.8e-58 195.2 0.0 7.4e-58 194.6 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein E2_bind PF08825.5 EDK38840.2 - 2.1e-30 104.3 0.2 3.2e-30 103.7 0.1 1.3 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 EDK38840.2 - 2.8e-27 94.0 0.8 5e-27 93.2 0.2 1.7 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein ThiF PF00899.16 EDK38840.2 - 6e-19 68.2 0.0 1.9e-18 66.6 0.0 1.8 2 0 0 2 2 2 1 ThiF family UBA_e1_thiolCys PF10585.4 EDK38840.2 - 4.4e-17 61.1 5.4 9.9e-17 60.0 3.7 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site MoeZ_MoeB PF05237.8 EDK38840.2 - 0.00036 20.0 0.6 0.0034 16.9 0.0 2.4 2 0 0 2 2 2 1 MoeZ/MoeB domain Ecm33 PF12454.3 EDK38840.2 - 0.032 14.0 1.4 0.064 13.1 1.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein UAE_UbL PF14732.1 EDK38840.2 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Abhydrolase_6 PF12697.2 EDK38841.2 - 2.9e-21 76.4 0.1 4.1e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK38841.2 - 2.2e-08 33.9 0.1 2.8e-07 30.3 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK38841.2 - 5.4e-05 22.9 0.0 0.00021 21.0 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 EDK38841.2 - 0.0011 18.6 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase MRJP PF03022.11 EDK38842.2 - 8.8e-28 97.3 0.0 1.3e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Major royal jelly protein PQQ_2 PF13360.1 EDK38842.2 - 0.00011 21.7 0.0 0.069 12.5 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain Cu-oxidase_2 PF07731.9 EDK38843.2 - 1.4e-44 150.9 8.8 2e-41 140.7 0.6 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 EDK38843.2 - 4.5e-41 139.2 8.6 6.1e-39 132.4 1.2 3.6 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EDK38843.2 - 1.5e-39 135.4 7.9 1.6e-34 119.1 0.8 3.3 3 1 0 3 3 3 2 Multicopper oxidase Col_cuticle_N PF01484.12 EDK38843.2 - 0.022 14.4 0.1 0.045 13.4 0.1 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain PetG PF02529.10 EDK38843.2 - 0.15 11.6 0.2 0.29 10.6 0.1 1.5 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 Adap_comp_sub PF00928.16 EDK38844.2 - 3.9e-36 124.5 0.0 4.1e-30 104.7 0.0 2.4 2 0 0 2 2 2 2 Adaptor complexes medium subunit family DPM2 PF07297.7 EDK38845.1 - 8.2e-34 115.7 2.2 9.8e-34 115.4 1.5 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.7 EDK38845.1 - 0.0009 18.8 0.3 0.00097 18.7 0.2 1.1 1 0 0 1 1 1 1 PIG-P ABC2_membrane_2 PF12679.2 EDK38845.1 - 0.018 13.8 3.0 0.02 13.7 2.1 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein MerE PF05052.7 EDK38845.1 - 0.056 13.4 1.7 0.081 12.9 0.1 1.8 2 0 0 2 2 2 0 MerE protein TauE PF01925.14 EDK38845.1 - 0.076 12.4 4.0 0.11 11.9 2.8 1.3 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE DUF1469 PF07332.6 EDK38845.1 - 0.13 12.0 0.8 0.17 11.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Lgl_C PF08596.5 EDK38846.2 - 5.6e-119 397.1 0.0 9.7e-119 396.3 0.0 1.4 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal Nucleoporin_N PF08801.6 EDK38846.2 - 0.00016 20.5 0.3 0.07 11.8 0.0 3.3 4 0 0 4 4 4 2 Nup133 N terminal like SMI1_KNR4 PF09346.5 EDK38846.2 - 0.028 14.4 0.0 3.4 7.6 0.0 3.1 3 0 0 3 3 3 0 SMI1 / KNR4 family (SUKH-1) WD40 PF00400.27 EDK38846.2 - 0.033 14.0 4.6 0.66 9.9 0.0 4.7 5 0 0 5 5 5 0 WD domain, G-beta repeat IKI3 PF04762.7 EDK38846.2 - 0.48 8.1 0.0 1.2 6.8 0.0 1.6 2 0 0 2 2 2 0 IKI3 family tRNA-synt_2b PF00587.20 EDK38847.2 - 1.2e-25 90.0 0.0 2.1e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 EDK38847.2 - 1.1e-08 35.0 8.0 1.1e-08 35.0 5.5 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain OmpH PF03938.9 EDK38847.2 - 0.036 14.0 0.3 0.082 12.8 0.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF342 PF03961.8 EDK38847.2 - 0.22 9.8 6.8 0.64 8.3 4.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) AA_permease PF00324.16 EDK38848.2 - 3e-121 405.1 33.6 3.7e-121 404.7 23.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK38848.2 - 3.6e-28 98.2 36.2 4.4e-28 97.9 25.1 1.0 1 0 0 1 1 1 1 Amino acid permease Nramp PF01566.13 EDK38848.2 - 0.0056 15.5 2.7 0.0056 15.5 1.9 3.4 3 1 1 4 4 4 1 Natural resistance-associated macrophage protein Peptidase_M3 PF01432.15 EDK38849.2 - 8.3e-111 371.2 2.3 1.1e-110 370.8 1.6 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 EDK38849.2 - 0.14 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Pkinase PF00069.20 EDK38850.2 - 9e-64 215.1 0.0 1.6e-63 214.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38850.2 - 1.5e-33 115.9 0.0 3.8e-32 111.3 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38850.2 - 1.5e-05 24.0 0.1 0.0084 15.1 0.0 3.0 3 0 0 3 3 3 2 Kinase-like LCD1 PF09798.4 EDK38850.2 - 0.0049 14.9 0.7 0.01 13.8 0.5 1.5 1 0 0 1 1 1 1 DNA damage checkpoint protein APH PF01636.18 EDK38850.2 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 EDK38850.2 - 0.18 10.8 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cid2 PF09774.4 EDK38851.1 - 4.4e-39 133.9 2.9 6.2e-39 133.5 2.0 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 FAD_binding_3 PF01494.14 EDK38851.1 - 0.081 11.9 0.0 0.088 11.8 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain TPR_11 PF13414.1 EDK38852.2 - 2.4e-11 43.1 1.8 3.4e-09 36.2 0.1 2.8 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 EDK38852.2 - 2.8e-08 33.0 0.0 0.047 13.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38852.2 - 6e-05 22.6 0.1 1 9.4 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38852.2 - 0.00062 19.6 0.3 0.1 12.5 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 EDK38852.2 - 0.019 14.1 0.0 2.7 7.3 0.0 2.7 3 0 0 3 3 3 0 SHNi-TPR Ribosomal_S20p PF01649.13 EDK38852.2 - 0.023 15.0 0.1 0.24 11.7 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein S20 TPR_9 PF13371.1 EDK38852.2 - 0.028 14.2 0.0 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Snf7 PF03357.16 EDK38853.2 - 3.1e-18 65.7 16.0 3.1e-18 65.7 11.1 1.2 1 1 0 1 1 1 1 Snf7 FKBP_C PF00254.23 EDK38853.2 - 0.086 12.8 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase Ist1 PF03398.9 EDK38853.2 - 0.19 11.1 5.8 0.45 9.9 4.0 1.6 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF3886 PF13025.1 EDK38853.2 - 0.55 10.2 7.2 0.52 10.3 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) PspA_IM30 PF04012.7 EDK38853.2 - 0.61 9.4 15.7 39 3.4 10.9 2.2 1 1 0 1 1 1 0 PspA/IM30 family Prominin PF05478.6 EDK38853.2 - 0.99 6.8 8.2 1.2 6.5 5.7 1.3 1 0 0 1 1 1 0 Prominin TPR_MLP1_2 PF07926.7 EDK38853.2 - 2.4 7.9 11.8 0.88 9.3 3.1 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.14 EDK38853.2 - 2.6 7.5 9.7 0.69 9.4 4.3 1.8 1 1 1 2 2 2 0 GrpE Sod_Fe_C PF02777.13 EDK38854.1 - 1.7e-36 124.2 0.4 3.6e-36 123.2 0.3 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 EDK38854.1 - 2.1e-29 101.6 1.2 3.7e-29 100.7 0.9 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HHH_2 PF12826.2 EDK38854.1 - 0.017 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Vps5 PF09325.5 EDK38856.1 - 1e-08 34.7 12.2 2.7e-08 33.3 8.4 1.6 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 EDK38856.1 - 0.00077 19.2 2.9 0.0082 15.9 0.0 2.7 2 1 0 2 2 2 1 PX domain Mito_carr PF00153.22 EDK38857.2 - 4.9e-09 35.7 0.0 0.0015 18.2 0.0 3.4 2 1 0 2 2 2 2 Mitochondrial carrier protein Syntaxin-6_N PF09177.6 EDK38858.2 - 4.8e-14 52.5 1.6 4.8e-14 52.5 1.1 2.9 2 2 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 EDK38858.2 - 3.5e-10 39.4 10.3 6.5e-10 38.5 4.6 2.6 3 0 0 3 3 3 1 SNARE domain DUF2267 PF10025.4 EDK38858.2 - 0.048 13.7 0.2 0.12 12.4 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) G0-G1_switch_2 PF15103.1 EDK38858.2 - 0.21 11.8 0.7 8.2 6.7 0.1 2.5 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF1845 PF08900.6 EDK38858.2 - 0.3 10.3 4.5 0.45 9.7 1.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1845) Sec20 PF03908.8 EDK38858.2 - 0.38 10.4 3.0 4 7.1 0.2 2.4 2 0 0 2 2 2 0 Sec20 DUF1664 PF07889.7 EDK38858.2 - 1.9 8.2 4.6 12 5.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 EDK38858.2 - 5 7.4 9.7 3.8 7.8 0.6 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TFIID-18kDa PF02269.11 EDK38860.2 - 6.5e-34 115.6 1.7 8.5e-34 115.2 0.1 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Acetyltransf_1 PF00583.19 EDK38861.1 - 3.4e-15 55.8 0.0 4.8e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EDK38861.1 - 8.7e-07 29.0 0.0 1.4e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EDK38861.1 - 3.1e-05 23.6 0.0 5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 EDK38861.1 - 9.2e-05 22.2 0.4 0.00019 21.2 0.0 1.8 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK38861.1 - 0.00031 20.8 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 EDK38861.1 - 0.0011 19.1 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain KH_1 PF00013.24 EDK38862.2 - 0.00026 20.5 0.3 0.00059 19.4 0.2 1.5 1 0 0 1 1 1 1 KH domain MDM31_MDM32 PF08118.6 EDK38863.2 - 1.6e-56 191.8 2.9 6.7e-34 117.2 0.1 3.1 2 1 0 3 3 3 3 Yeast mitochondrial distribution and morphology (MDM) proteins G-patch_2 PF12656.2 EDK38864.2 - 6.4e-20 70.7 1.6 1e-19 70.1 0.2 2.0 2 0 0 2 2 2 1 DExH-box splicing factor binding site G-patch PF01585.18 EDK38864.2 - 0.097 12.4 1.7 0.14 11.9 0.0 2.2 3 0 0 3 3 3 0 G-patch domain AAA PF00004.24 EDK38865.2 - 3.5e-07 30.4 0.0 8.8e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) VirE PF05272.6 EDK38865.2 - 0.02 14.3 0.0 7.4 5.9 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E DUF258 PF03193.11 EDK38865.2 - 0.033 13.3 0.0 0.07 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK38865.2 - 0.076 12.9 0.0 0.25 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 EDK38865.2 - 0.1 12.7 0.0 0.36 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain TRAPP PF04051.11 EDK38866.2 - 3.3e-41 140.3 0.0 3.9e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Y_phosphatase PF00102.22 EDK38869.2 - 1.2e-61 208.0 0.0 1.9e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 EDK38869.2 - 7.4e-13 48.8 0.0 2.4e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.15 EDK38869.2 - 0.00029 20.4 0.0 0.00067 19.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 EDK38869.2 - 0.0075 16.5 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Thioredoxin PF00085.15 EDK38870.1 - 5.4e-30 103.1 0.0 5.9e-30 103.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK38870.1 - 1.1e-08 35.0 0.1 6.1e-06 26.2 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EDK38870.1 - 2.5e-07 30.8 0.2 3.1e-06 27.3 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EDK38870.1 - 1.7e-05 24.4 0.0 1.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.11 EDK38870.1 - 0.00013 20.7 0.0 0.00015 20.6 0.0 1.0 1 0 0 1 1 1 1 Phosducin Glutaredoxin PF00462.19 EDK38870.1 - 0.00049 20.0 0.0 0.00093 19.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Redoxin PF08534.5 EDK38870.1 - 0.001 18.6 0.1 0.0045 16.5 0.1 1.8 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.16 EDK38870.1 - 0.0012 18.5 0.1 0.0022 17.7 0.1 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_3 PF13192.1 EDK38870.1 - 0.0013 18.5 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.1 EDK38870.1 - 0.0037 17.2 0.1 0.0056 16.6 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.1 EDK38870.1 - 0.0091 15.5 0.0 0.012 15.0 0.0 1.3 1 1 0 1 1 1 1 F plasmid transfer operon protein HyaE PF07449.6 EDK38870.1 - 0.069 13.0 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_6 PF13848.1 EDK38870.1 - 0.074 12.8 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DIM1 PF02966.11 EDK38870.1 - 0.081 12.4 0.0 0.092 12.2 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 eIF3_subunit PF08597.5 EDK38872.2 - 5.3e-70 235.7 24.1 6.5e-70 235.4 16.7 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit His_Phos_1 PF00300.17 EDK38873.1 - 3.6e-16 59.6 0.0 6.5e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Dynactin_p62 PF05502.8 EDK38874.2 - 8.9e-10 37.9 22.1 0.00014 20.7 12.1 2.5 1 1 1 2 2 2 2 Dynactin p62 family RNA_POL_M_15KD PF02150.11 EDK38874.2 - 0.059 13.0 7.0 1.1 8.9 0.1 3.7 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit FAD-oxidase_C PF02913.14 EDK38875.2 - 6e-54 182.9 0.0 9.6e-54 182.3 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 EDK38875.2 - 5.8e-37 126.2 0.0 1.3e-36 125.1 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain TPR_11 PF13414.1 EDK38876.2 - 6.7e-19 67.2 8.5 9.9e-16 57.1 2.6 2.6 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 EDK38876.2 - 4.5e-13 48.1 2.9 0.00022 20.6 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 EDK38876.2 - 5.8e-11 41.4 5.0 0.0095 15.7 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 EDK38876.2 - 1.3e-07 31.2 1.4 0.0096 16.0 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 EDK38876.2 - 2.3e-05 24.6 1.7 0.76 10.5 0.4 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 EDK38876.2 - 4e-05 23.4 6.3 0.00067 19.5 2.3 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 EDK38876.2 - 0.00013 21.5 1.1 10 6.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38876.2 - 0.00041 20.9 5.5 0.0016 19.0 1.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK38876.2 - 0.00043 19.8 6.5 0.1 12.4 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 EDK38876.2 - 0.016 15.4 2.2 1.2 9.4 0.3 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4661 PF15576.1 EDK38876.2 - 0.057 13.0 1.5 0.084 12.5 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) BTAD PF03704.12 EDK38876.2 - 0.22 11.8 5.0 0.2 11.9 0.8 2.6 3 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.1 EDK38876.2 - 4 8.1 9.2 4.7 7.8 0.8 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat VPS9 PF02204.13 EDK38877.2 - 4.1e-09 36.4 1.6 6.2e-09 35.8 0.5 1.8 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 EDK38877.2 - 1.8e-05 24.8 0.1 0.19 12.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK38877.2 - 6.1e-05 23.2 0.0 0.054 13.8 0.0 3.5 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK38877.2 - 9.4e-05 22.8 0.7 1.4 9.5 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK38877.2 - 0.00045 20.1 0.3 0.014 15.5 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.25 EDK38877.2 - 0.0034 17.1 0.0 0.1 12.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Hydantoinase_B PF02538.9 EDK38878.2 - 6.4e-177 588.9 0.1 8.4e-177 588.5 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase DUF4154 PF13689.1 EDK38879.2 - 0.043 13.4 0.0 0.05 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4154) Hydantoinase_B PF02538.9 EDK38880.1 - 0.001 17.4 0.0 0.0016 16.7 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EDK38881.2 - 3.1e-71 239.8 0.1 3.7e-71 239.5 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase DUF367 PF04034.8 EDK38882.1 - 3.9e-54 181.6 0.0 5.6e-54 181.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 EDK38882.1 - 2.2e-16 59.1 0.4 3.8e-16 58.3 0.3 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Ribonuc_red_sm PF00268.16 EDK38883.1 - 1.3e-124 414.7 1.6 1.6e-124 414.4 1.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Fib_succ_major PF09603.5 EDK38883.1 - 0.092 13.2 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 Fibrobacter succinogenes major domain (Fib_succ_major) RE_XcyI PF09571.5 EDK38883.1 - 0.14 11.0 0.2 0.85 8.4 0.0 1.9 2 0 0 2 2 2 0 XcyI restriction endonuclease PH PF00169.24 EDK38884.2 - 0.045 13.9 0.1 0.25 11.5 0.0 2.2 2 0 0 2 2 2 0 PH domain DNA_ligase_A_M PF01068.16 EDK38885.2 - 1.5e-55 187.6 0.1 2.6e-55 186.9 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EDK38885.2 - 3.9e-17 62.6 0.1 7.8e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EDK38885.2 - 2.6e-08 34.1 0.0 1e-07 32.2 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.14 EDK38885.2 - 8.1e-06 25.6 3.5 0.012 15.3 0.1 3.2 3 1 0 3 3 3 2 mRNA capping enzyme, catalytic domain BRCT PF00533.21 EDK38885.2 - 2.2e-05 24.5 0.2 0.2 11.8 0.0 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Abhydrolase_6 PF12697.2 EDK38886.2 - 2e-14 54.0 0.1 2.5e-14 53.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK38886.2 - 9.5e-07 28.6 0.0 2.9e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK38886.2 - 0.016 14.7 0.1 0.39 10.2 0.1 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold NDUF_B6 PF09782.4 EDK38886.2 - 0.12 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Sugar_tr PF00083.19 EDK38887.2 - 3.9e-67 226.7 25.3 1e-65 222.1 17.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK38887.2 - 9.6e-36 123.2 38.2 1.5e-31 109.3 14.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2763 PF10961.3 EDK38887.2 - 0.2 12.0 0.5 0.43 10.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) PI-PLC-X PF00388.14 EDK38888.2 - 6.6e-20 71.0 0.0 1.2e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF697 PF05128.7 EDK38888.2 - 0.05 13.1 0.0 0.078 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF697) DUF2286 PF10051.4 EDK38888.2 - 0.083 12.5 0.1 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2286) She9_MDM33 PF05546.6 EDK38889.2 - 1.6e-95 318.5 11.1 3.1e-95 317.6 7.7 1.4 1 0 0 1 1 1 1 She9 / Mdm33 family PsbH PF00737.15 EDK38889.2 - 0.0041 16.6 0.4 0.0084 15.6 0.3 1.4 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein DUF4206 PF13901.1 EDK38889.2 - 0.013 15.1 3.6 0.11 11.9 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) DUF4041 PF13250.1 EDK38889.2 - 0.5 9.9 0.0 0.5 9.9 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4041) CENP-Q PF13094.1 EDK38889.2 - 4.4 7.3 16.7 0.36 10.8 5.2 2.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit AAA PF00004.24 EDK38890.1 - 1e-45 155.1 0.0 2.4e-45 153.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 EDK38890.1 - 6.1e-09 36.0 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EDK38890.1 - 2.4e-07 30.9 0.0 8.7e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 EDK38890.1 - 6.9e-07 29.0 0.2 2.6e-06 27.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EDK38890.1 - 1.3e-06 28.6 0.4 0.00013 22.1 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EDK38890.1 - 4.5e-05 23.3 0.0 0.00013 21.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 EDK38890.1 - 8e-05 21.6 0.0 0.00017 20.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 EDK38890.1 - 0.00062 18.9 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin RuvB_N PF05496.7 EDK38890.1 - 0.0007 18.7 0.0 0.0015 17.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EDK38890.1 - 0.00091 20.0 0.4 0.0034 18.1 0.0 2.0 2 1 0 2 2 1 1 AAA domain NACHT PF05729.7 EDK38890.1 - 0.001 18.7 0.2 0.066 12.8 0.0 2.4 2 0 0 2 2 2 1 NACHT domain NTPase_1 PF03266.10 EDK38890.1 - 0.0015 18.2 0.0 0.0045 16.7 0.0 1.8 2 0 0 2 2 1 1 NTPase AAA_33 PF13671.1 EDK38890.1 - 0.0016 18.3 0.0 0.0033 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK38890.1 - 0.0019 17.8 0.2 0.0052 16.5 0.2 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_3 PF07726.6 EDK38890.1 - 0.0032 17.0 0.0 0.015 14.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 EDK38890.1 - 0.0036 17.2 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EDK38890.1 - 0.0052 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 EDK38890.1 - 0.0057 16.0 1.1 0.087 12.2 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.1 EDK38890.1 - 0.0057 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EDK38890.1 - 0.0079 15.3 0.1 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 EDK38890.1 - 0.0087 14.8 0.0 0.016 13.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_11 PF13086.1 EDK38890.1 - 0.011 15.3 0.0 0.024 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 EDK38890.1 - 0.012 15.1 0.1 0.13 11.6 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 EDK38890.1 - 0.017 14.5 0.0 0.041 13.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Arch_ATPase PF01637.13 EDK38890.1 - 0.02 14.6 0.1 0.22 11.2 0.0 2.3 1 1 1 2 2 2 0 Archaeal ATPase AAA_30 PF13604.1 EDK38890.1 - 0.02 14.4 0.0 0.055 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 EDK38890.1 - 0.027 14.7 0.0 0.096 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 EDK38890.1 - 0.03 13.9 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 EDK38890.1 - 0.038 14.2 0.5 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 EDK38890.1 - 0.058 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein KaiC PF06745.8 EDK38890.1 - 0.11 11.5 0.1 0.61 9.1 0.0 2.1 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.17 EDK38890.1 - 0.13 11.1 0.0 0.26 10.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.12 EDK38890.1 - 0.17 10.6 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Glyco_transf_22 PF03901.12 EDK38891.2 - 1.9e-66 224.7 24.5 2.5e-66 224.4 17.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Utp12 PF04003.7 EDK38892.2 - 1.8e-23 82.5 0.6 3.8e-23 81.4 0.4 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family Utp21 PF04192.7 EDK38892.2 - 0.0012 17.9 1.3 0.0021 17.2 0.9 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain UTP15_C PF09384.5 EDK38892.2 - 0.0045 16.6 0.1 0.01 15.5 0.1 1.6 1 0 0 1 1 1 1 UTP15 C terminal Cwf_Cwc_15 PF04889.7 EDK38892.2 - 0.08 12.6 0.2 0.08 12.6 0.1 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_6 PF12697.2 EDK38893.2 - 1.5e-28 100.2 0.0 2.1e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK38893.2 - 1.5e-13 50.8 0.1 7.3e-12 45.3 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK38893.2 - 1.4e-11 44.3 0.0 2e-11 43.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EDK38893.2 - 3.7e-08 33.8 0.0 4.8e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 EDK38893.2 - 9.5e-06 25.3 0.1 2e-05 24.3 0.1 1.5 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.3 EDK38893.2 - 0.00017 21.4 0.0 0.0004 20.1 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Esterase PF00756.15 EDK38893.2 - 0.00052 19.5 0.0 0.00074 19.0 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Lipase_3 PF01764.20 EDK38893.2 - 0.027 14.0 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydro_lipase PF04083.11 EDK38893.2 - 0.07 12.4 0.1 0.15 11.4 0.1 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Ndr PF03096.9 EDK38893.2 - 0.14 10.6 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Ndr family CBFD_NFYB_HMF PF00808.18 EDK38894.2 - 3.8e-13 49.2 1.8 6.2e-13 48.6 1.2 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK38894.2 - 0.0098 15.9 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF1043 PF06295.7 EDK38894.2 - 0.067 12.8 2.0 0.11 12.1 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF3510 PF12022.3 EDK38894.2 - 0.093 12.8 0.9 0.13 12.3 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) DUF3753 PF12575.3 EDK38894.2 - 0.11 12.2 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Bromo_TP PF07524.8 EDK38894.2 - 0.12 12.0 0.1 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Orthopox_B11R PF07033.6 EDK38894.2 - 4.4 6.8 6.6 1.3 8.5 1.6 2.2 2 1 0 2 2 2 0 Orthopoxvirus B11R protein Yos1 PF08571.5 EDK38895.1 - 1.5e-33 114.7 0.9 1.7e-33 114.5 0.6 1.1 1 0 0 1 1 1 1 Yos1-like O-antigen_lig PF13425.1 EDK38895.1 - 0.069 13.1 1.2 0.091 12.7 0.8 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RabGAP-TBC PF00566.13 EDK38896.2 - 8.1e-36 123.4 0.1 1.1e-35 123.0 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HSP70 PF00012.15 EDK38897.2 - 1.8e-52 178.1 22.1 4.1e-52 176.9 0.1 3.1 3 0 0 3 3 3 2 Hsp70 protein Pribosyltran PF00156.22 EDK38898.1 - 1.1e-11 44.4 0.0 1.8e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Fe-ADH PF00465.14 EDK38898.1 - 0.029 13.0 0.0 0.042 12.4 0.0 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Mito_fiss_Elm1 PF06258.6 EDK38898.1 - 0.061 12.2 0.0 0.093 11.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 UFD1 PF03152.9 EDK38899.2 - 4.3e-73 244.1 0.0 5.5e-73 243.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Cse1 PF08506.5 EDK38901.2 - 1.8e-12 46.5 2.6 1.8e-12 46.5 1.8 2.3 2 1 0 2 2 2 1 Cse1 MOR2-PAG1_C PF14225.1 EDK38901.2 - 0.014 15.1 2.6 0.023 14.4 0.6 2.2 2 1 0 2 2 2 0 Cell morphogenesis C-terminal IBN_N PF03810.14 EDK38902.2 - 1.3e-12 47.4 0.1 4.2e-12 45.8 0.0 1.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain RRP7 PF12923.2 EDK38903.2 - 1.8e-36 125.0 11.1 2.7e-36 124.4 7.7 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) RRM_1 PF00076.17 EDK38903.2 - 0.047 13.3 1.9 5 6.8 0.0 3.4 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF45 PF01863.12 EDK38903.2 - 0.13 12.0 2.9 0.21 11.3 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 Ribosomal_L14e PF01929.12 EDK38903.2 - 0.7 10.2 7.7 0.28 11.5 2.9 2.1 1 1 1 2 2 2 0 Ribosomal protein L14 Aminotran_4 PF01063.14 EDK38904.2 - 6.2e-32 110.9 0.0 7.8e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV HAD PF12710.2 EDK38905.1 - 2.6e-16 60.3 0.1 3.7e-16 59.8 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK38905.1 - 1.2e-12 47.9 0.6 3.1e-10 40.0 0.0 3.2 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK38905.1 - 4.4e-11 43.5 1.6 2.6e-09 37.7 0.5 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EDK38905.1 - 2.5e-07 31.0 0.0 1.1e-06 29.0 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 EDK38905.1 - 0.0004 19.6 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 Putative Phosphatase DUF705 PF05152.7 EDK38905.1 - 0.033 13.1 0.7 0.11 11.4 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF705) Nt_Gln_amidase PF09764.4 EDK38905.1 - 0.1 11.8 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 N-terminal glutamine amidase Toxin_ToxA PF11584.3 EDK38905.1 - 0.12 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA CRAL_TRIO PF00650.15 EDK38906.2 - 2.6e-36 124.5 0.0 4.1e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EDK38906.2 - 1.4e-16 60.3 0.8 3.5e-16 59.0 0.2 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EDK38906.2 - 0.078 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Tctex-1 PF03645.8 EDK38907.2 - 2.6e-06 27.2 0.1 2.6e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Tctex-1 family CENP-Q PF13094.1 EDK38908.2 - 1.9e-29 102.7 8.6 1.9e-29 102.7 6.0 1.5 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.4 EDK38908.2 - 0.017 15.2 6.7 0.19 11.8 3.2 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CXCL17 PF15211.1 EDK38908.2 - 0.086 13.2 0.1 0.16 12.4 0.1 1.4 1 0 0 1 1 1 0 VEGF co-regulated chemokine 1 IncA PF04156.9 EDK38908.2 - 0.13 11.8 11.5 0.061 12.9 5.8 1.9 2 1 0 2 2 2 0 IncA protein Auxin_repressed PF05564.7 EDK38908.2 - 5.7 7.5 8.8 8.2 7.0 1.6 2.6 3 0 0 3 3 3 0 Dormancy/auxin associated protein RRN7 PF11781.3 EDK38909.2 - 5.6e-12 44.9 0.2 9.2e-12 44.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 Aldedh PF00171.17 EDK38910.1 - 4.3e-184 612.1 0.4 4.9e-184 611.9 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 EDK38910.1 - 0.035 13.3 0.2 1.1 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Sec6 PF06046.8 EDK38911.2 - 4.8e-195 648.8 15.4 9.4e-195 647.9 10.2 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec6 Coatamer_beta_C PF07718.7 EDK38911.2 - 0.0072 15.9 1.5 0.016 14.8 1.0 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region DASH_Dam1 PF08653.5 EDK38911.2 - 0.026 14.3 0.1 0.12 12.1 0.1 2.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 LsmAD PF06741.8 EDK38912.2 - 5.4e-28 96.8 1.5 1.2e-27 95.7 1.1 1.7 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.1 EDK38912.2 - 1.1e-06 28.4 0.0 3.7e-06 26.7 0.0 2.0 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.10 EDK38912.2 - 0.11 12.0 1.9 0.42 10.2 1.4 2.1 1 0 0 1 1 1 0 Ataxin-2 C-terminal region DUF4573 PF15140.1 EDK38913.2 - 0.07 12.7 0.0 0.35 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4573) ATG16 PF08614.6 EDK38914.1 - 1e-27 97.2 18.6 3.7e-24 85.6 12.4 2.0 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 EDK38914.1 - 0.00095 17.0 16.4 0.00095 17.0 11.4 1.3 2 0 0 2 2 2 1 Myosin tail HAP1_N PF04849.8 EDK38914.1 - 0.0011 17.9 11.8 0.0015 17.5 8.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Reo_sigmaC PF04582.7 EDK38914.1 - 0.0061 15.7 1.3 0.0068 15.6 0.9 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Flagellar_rod PF05149.7 EDK38914.1 - 0.0084 15.3 11.3 0.013 14.7 7.8 1.3 1 0 0 1 1 1 1 Paraflagellar rod protein GAS PF13851.1 EDK38914.1 - 0.017 14.3 18.4 0.022 13.9 7.2 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.10 EDK38914.1 - 0.02 14.8 11.9 0.029 14.4 8.3 1.2 1 0 0 1 1 1 0 Fez1 IncA PF04156.9 EDK38914.1 - 0.037 13.6 11.8 0.046 13.3 8.2 1.2 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 EDK38914.1 - 0.039 13.7 20.5 0.36 10.6 12.0 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.1 EDK38914.1 - 0.049 13.0 18.1 0.041 13.3 7.2 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.6 EDK38914.1 - 0.051 12.2 17.3 0.069 11.8 10.3 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.4 EDK38914.1 - 0.051 12.5 14.1 0.072 12.0 9.6 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Lge1 PF11488.3 EDK38914.1 - 0.079 13.1 11.6 0.34 11.1 8.1 2.2 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 AAA_13 PF13166.1 EDK38914.1 - 0.2 10.1 11.3 0.23 9.9 7.8 1.1 1 0 0 1 1 1 0 AAA domain SlyX PF04102.7 EDK38914.1 - 0.22 11.9 14.9 0.59 10.5 1.5 2.7 1 1 1 2 2 2 0 SlyX DUF1049 PF06305.6 EDK38914.1 - 0.26 10.7 4.2 2.6 7.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) APG6 PF04111.7 EDK38914.1 - 0.26 10.2 16.2 0.03 13.3 7.7 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 SLIDE PF09111.5 EDK38914.1 - 0.28 10.9 5.3 0.45 10.2 3.5 1.5 1 1 0 1 1 1 0 SLIDE V_ATPase_I PF01496.14 EDK38914.1 - 0.39 8.5 9.0 0.47 8.2 6.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glutaredoxin2_C PF04399.8 EDK38914.1 - 0.42 10.1 5.9 1.4 8.4 3.8 2.2 1 1 0 1 1 1 0 Glutaredoxin 2, C terminal domain ISG65-75 PF11727.3 EDK38914.1 - 0.5 9.3 10.7 2.1 7.3 3.4 2.1 1 1 1 2 2 2 0 Invariant surface glycoprotein OEP PF02321.13 EDK38914.1 - 0.63 9.6 10.6 0.66 9.5 6.8 1.4 1 1 0 1 1 1 0 Outer membrane efflux protein bZIP_1 PF00170.16 EDK38914.1 - 0.77 9.7 17.1 0.77 9.7 0.7 3.3 2 1 1 3 3 3 0 bZIP transcription factor DUF2630 PF10944.3 EDK38914.1 - 0.81 9.8 4.4 0.86 9.7 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2630) CALCOCO1 PF07888.6 EDK38914.1 - 0.93 7.7 14.8 1.6 6.9 10.3 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.3 EDK38914.1 - 1.4 8.7 17.3 1 9.2 9.8 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Val_tRNA-synt_C PF10458.4 EDK38914.1 - 1.6 8.8 12.7 10 6.2 0.7 3.5 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm DUF641 PF04859.7 EDK38914.1 - 1.8 8.3 11.4 1.4 8.6 3.5 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Cep57_MT_bd PF06657.8 EDK38914.1 - 2.1 8.3 10.1 0.11 12.4 0.7 2.8 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 TPR_MLP1_2 PF07926.7 EDK38914.1 - 2.2 8.0 19.2 5.5 6.7 13.3 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3810 PF12725.2 EDK38914.1 - 4.5 6.0 6.5 3.1 6.6 1.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Adeno_PIX PF03955.9 EDK38914.1 - 4.5 7.8 5.8 1.2 9.6 0.7 2.1 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) Macoilin PF09726.4 EDK38914.1 - 6.1 4.9 14.6 2.8 6.1 8.0 1.7 1 1 1 2 2 2 0 Transmembrane protein DUF4404 PF14357.1 EDK38914.1 - 6.2 7.3 10.5 2.2 8.7 2.9 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) DivIVA PF05103.8 EDK38914.1 - 6.7 6.7 16.8 1.3e+02 2.5 11.6 2.3 1 1 0 1 1 1 0 DivIVA protein Glyco_transf_22 PF03901.12 EDK38915.2 - 9.6e-46 156.6 20.1 1.2e-45 156.3 13.9 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Calpain_III PF01067.17 EDK38916.2 - 1.4e-05 24.7 3.0 3.6e-05 23.4 0.2 2.9 3 1 0 3 3 3 1 Calpain large subunit, domain III Peptidase_C2 PF00648.16 EDK38916.2 - 0.00076 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease MHC_I_2 PF14586.1 EDK38916.2 - 0.028 14.0 0.2 1.4 8.4 0.1 2.7 2 0 0 2 2 2 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 OST3_OST6 PF04756.8 EDK38917.2 - 3.8e-22 78.5 5.8 7.9e-22 77.5 4.0 1.5 1 0 0 1 1 1 1 OST3 / OST6 family DUF1980 PF09323.5 EDK38917.2 - 0.0049 16.6 5.8 0.0091 15.7 0.5 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1980) Thioredoxin PF00085.15 EDK38917.2 - 0.02 14.5 0.0 0.3 10.7 0.0 2.2 1 1 0 1 1 1 0 Thioredoxin VIT1 PF01988.14 EDK38917.2 - 5.2 6.5 6.9 3.8 6.9 0.5 2.2 2 0 0 2 2 2 0 VIT family EamA PF00892.15 EDK38917.2 - 7.6 6.5 15.6 0.18 11.8 2.0 2.9 3 0 0 3 3 3 0 EamA-like transporter family DUF3238 PF11579.3 EDK38918.2 - 0.11 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3238) RNA_pol_Rpb4 PF03874.11 EDK38919.1 - 5.1e-29 100.6 0.8 6.3e-29 100.3 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Ten1 PF12658.2 EDK38920.1 - 4.2e-21 74.9 0.0 5.2e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Fungal_trans PF04082.13 EDK38921.2 - 8.7e-25 87.0 0.5 8.7e-25 87.0 0.3 1.9 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK38922.2 - 1.1e-10 41.2 10.1 1.6e-10 40.6 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HypA PF01155.14 EDK38922.2 - 0.15 11.7 2.4 0.23 11.1 1.6 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family CmcH_NodU PF02543.10 EDK38924.2 - 0.079 12.0 0.7 0.13 11.3 0.5 1.3 1 0 0 1 1 1 0 Carbamoyltransferase SPRY PF00622.23 EDK38925.2 - 1.4e-05 25.1 0.0 0.0003 20.8 0.0 2.3 2 0 0 2 2 2 1 SPRY domain SMC_Nse1 PF07574.8 EDK38926.2 - 2.7e-24 85.9 1.1 2.1e-23 83.0 0.7 1.9 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 EDK38926.2 - 0.00069 19.5 9.3 0.002 18.0 6.4 1.8 1 1 1 2 2 2 1 RING-like domain zf-rbx1 PF12678.2 EDK38926.2 - 0.012 15.6 3.6 0.024 14.7 2.5 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger IpaB_EvcA PF03278.8 EDK38926.2 - 0.022 13.9 2.8 0.031 13.5 1.9 1.2 1 0 0 1 1 1 0 IpaB/EvcA family zf-RING_2 PF13639.1 EDK38926.2 - 0.045 13.5 7.5 0.094 12.5 5.2 1.5 1 0 0 1 1 1 0 Ring finger domain Chordopox_A30L PF06015.7 EDK38926.2 - 0.068 12.7 0.1 0.068 12.7 0.1 1.7 2 0 0 2 2 2 0 Chordopoxvirus A30L protein C1_1 PF00130.17 EDK38926.2 - 0.11 12.2 8.1 0.21 11.3 5.6 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Glyco_hydro_16 PF00722.16 EDK38927.2 - 1.1e-39 135.6 0.0 1.6e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PFK PF00365.15 EDK38928.2 - 3.7e-164 544.5 0.7 7.8e-123 408.9 0.5 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.14 EDK38928.2 - 0.02 14.3 0.9 0.068 12.7 0.6 2.0 1 0 0 1 1 1 0 UvrB/uvrC motif HSF_DNA-bind PF00447.12 EDK38929.2 - 1.1e-36 125.1 0.5 2.4e-36 124.0 0.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding DUF2702 PF10863.3 EDK38930.2 - 3.3e-34 117.6 4.3 3.3e-34 117.6 3.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2702) DUF3245 PF11595.3 EDK38930.2 - 0.0051 17.1 12.2 0.0086 16.3 8.5 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3245) Got1 PF04178.7 EDK38932.1 - 3.5e-19 69.0 6.0 3.8e-19 68.9 4.1 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF973 PF06157.6 EDK38932.1 - 0.013 14.4 6.1 0.017 14.1 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Na_Ca_ex PF01699.19 EDK38932.1 - 0.15 11.6 4.1 0.22 11.1 2.8 1.3 1 1 0 1 1 1 0 Sodium/calcium exchanger protein YrhK PF14145.1 EDK38932.1 - 0.18 11.4 5.2 0.23 11.1 2.0 2.3 2 1 0 2 2 2 0 YrhK-like protein PEMT PF04191.8 EDK38932.1 - 0.34 11.0 3.3 0.55 10.3 0.4 2.0 2 0 0 2 2 2 0 Phospholipid methyltransferase ATP1G1_PLM_MAT8 PF02038.11 EDK38932.1 - 3.3 6.7 7.4 7.5 5.6 0.6 2.4 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DnaJ_CXXCXGXG PF00684.14 EDK38933.2 - 0.00043 20.2 18.2 0.11 12.5 0.3 3.2 2 1 1 3 3 3 3 DnaJ central domain DUF2318 PF10080.4 EDK38933.2 - 0.003 17.2 6.4 0.14 11.9 0.4 2.4 2 0 0 2 2 2 2 Predicted membrane protein (DUF2318) HypA PF01155.14 EDK38933.2 - 0.037 13.7 6.5 1.5 8.5 0.3 3.0 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family DUF3624 PF12292.3 EDK38933.2 - 0.52 10.7 5.7 5.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) Cytochrom_c3_2 PF14537.1 EDK38933.2 - 1.7 9.0 11.8 16 5.9 6.3 2.6 2 1 1 3 3 3 0 Cytochrome c3 Aldedh PF00171.17 EDK38934.2 - 1.7e-105 353.0 0.0 2.1e-105 352.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MMR_HSR1 PF01926.18 EDK38935.2 - 1.8e-19 69.8 0.2 3.9e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 EDK38935.2 - 1.9e-19 69.2 0.1 3.9e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 EDK38935.2 - 1.5e-14 53.5 0.1 2.5e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EDK38935.2 - 1.6e-05 24.7 1.4 0.0072 16.1 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 EDK38935.2 - 0.00038 20.9 0.1 0.00084 19.8 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 EDK38935.2 - 0.0046 16.0 0.2 0.0077 15.3 0.1 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.5 EDK38935.2 - 0.059 12.5 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MCM PF00493.18 EDK38935.2 - 0.076 11.8 0.2 0.15 10.8 0.0 1.5 2 0 0 2 2 2 0 MCM2/3/5 family DUF2361 PF10153.4 EDK38936.2 - 5.5e-41 139.3 16.4 5.5e-41 139.3 11.4 1.9 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2361) Peptidase_C12 PF01088.16 EDK38936.2 - 0.024 13.8 0.4 0.042 13.0 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF4460 PF14687.1 EDK38936.2 - 0.21 11.3 4.2 0.12 12.1 1.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) Prismane PF03063.15 EDK38936.2 - 0.65 8.2 3.0 0.78 8.0 1.9 1.2 1 1 0 1 1 1 0 Prismane/CO dehydrogenase family PAPS_reduct PF01507.14 EDK38936.2 - 7.9 6.2 6.7 4.4 7.0 3.1 1.7 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Sec63 PF02889.11 EDK38937.2 - 6.5e-47 160.2 0.3 1.2e-46 159.4 0.2 1.3 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.26 EDK38937.2 - 1.2e-08 34.7 0.1 4.4e-08 32.8 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Sec63 PF02889.11 EDK38938.2 - 4.3e-35 121.4 0.0 5.4e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 EDK38938.2 - 7.9e-15 54.7 0.0 1.1e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK38938.2 - 3e-06 27.1 0.0 4.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EDK38938.2 - 0.00077 19.1 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 EDK38938.2 - 0.0027 17.3 0.0 0.0055 16.3 0.0 1.5 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 EDK38938.2 - 0.0057 15.9 0.0 0.0097 15.1 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein Sec63 PF02889.11 EDK38939.2 - 8.4e-52 176.3 1.5 3.6e-50 170.9 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 EDK38939.2 - 2.3e-29 102.0 1.9 5.8e-28 97.4 0.5 3.5 4 0 0 4 4 4 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK38939.2 - 5.2e-09 36.1 0.1 5.2e-09 36.1 0.1 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EDK38939.2 - 2.5e-07 30.4 0.0 8.3e-07 28.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EDK38939.2 - 0.027 14.6 2.1 0.095 12.8 0.2 2.9 3 1 0 3 3 3 0 AAA domain IstB_IS21 PF01695.12 EDK38939.2 - 0.029 13.7 0.2 1.4 8.3 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein DEAD PF00270.24 EDK38940.2 - 6.4e-44 149.4 1.8 1.1e-43 148.6 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK38940.2 - 1.9e-21 75.6 0.0 4e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 EDK38940.2 - 6e-19 67.3 0.1 1.3e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DNA_pol_E_B PF04042.11 EDK38941.2 - 5e-44 150.0 0.2 9.5e-44 149.1 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B RNB PF00773.14 EDK38942.2 - 9.4e-61 205.8 1.2 9.4e-61 205.8 0.8 2.1 3 0 0 3 3 3 1 RNB domain OB_RNB PF08206.6 EDK38942.2 - 0.0023 17.3 0.1 0.87 9.1 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease B OB domain GTP_cyclohydroI PF01227.17 EDK38943.1 - 6.8e-78 260.0 0.1 8.2e-78 259.7 0.1 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 EDK38943.1 - 6e-05 22.9 0.0 0.00027 20.8 0.0 1.9 2 0 0 2 2 2 1 QueF-like protein DUF2703 PF10865.3 EDK38943.1 - 0.094 12.6 0.6 0.2 11.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) Amidase PF01425.16 EDK38944.2 - 4e-109 365.4 0.4 4.8e-109 365.1 0.3 1.0 1 0 0 1 1 1 1 Amidase tRNA-synt_1g PF09334.6 EDK38945.2 - 1e-147 491.9 0.9 1.4e-147 491.5 0.7 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.5 EDK38945.2 - 2.3e-20 73.2 0.2 4.9e-20 72.1 0.1 1.6 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.17 EDK38945.2 - 9.3e-08 30.5 1.1 0.00081 17.5 0.0 3.2 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 EDK38945.2 - 0.0069 15.5 0.4 0.033 13.3 0.1 2.1 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain DZR PF12773.2 EDK38945.2 - 0.48 10.2 3.6 1.1 9.0 2.5 1.6 1 0 0 1 1 1 0 Double zinc ribbon PS_Dcarbxylase PF02666.10 EDK38946.2 - 3.4e-54 183.2 0.0 5.3e-54 182.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 EDK38946.2 - 2.7e-20 71.9 2.5 5.4e-13 48.5 0.1 3.1 2 1 0 2 2 2 2 C2 domain DUF3668 PF12416.3 EDK38946.2 - 0.018 14.2 0.0 0.042 13.0 0.0 1.5 1 0 0 1 1 1 0 Cep120 protein SRP54 PF00448.17 EDK38947.2 - 4.6e-47 160.0 1.8 5.5e-47 159.7 0.3 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.8 EDK38947.2 - 4.2e-08 32.9 3.3 8.6e-08 31.9 2.3 1.4 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal ArgK PF03308.11 EDK38947.2 - 7.5e-08 31.4 0.2 1.5e-07 30.4 0.0 1.5 2 0 0 2 2 2 1 ArgK protein CbiA PF01656.18 EDK38947.2 - 9.2e-06 25.1 0.1 2.1e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.1 EDK38947.2 - 0.0031 17.6 0.1 0.017 15.2 0.0 2.4 3 1 0 3 3 3 1 AAA domain SRX PF09201.5 EDK38947.2 - 0.0057 16.3 0.8 0.011 15.4 0.1 1.9 2 0 0 2 2 2 1 SRX AAA_10 PF12846.2 EDK38947.2 - 0.027 13.9 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain SRP54_N PF02881.14 EDK38947.2 - 0.035 14.2 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain MobB PF03205.9 EDK38947.2 - 0.038 13.7 0.0 0.093 12.4 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Borrelia_lipo_2 PF06238.6 EDK38947.2 - 0.041 13.9 1.6 1 9.4 0.2 2.9 2 0 0 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein AAA_14 PF13173.1 EDK38947.2 - 0.044 13.6 0.0 0.16 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 EDK38947.2 - 0.05 13.0 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 EDK38947.2 - 0.09 12.3 0.5 0.6 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 EDK38947.2 - 0.48 9.6 4.8 2 7.6 0.1 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Yip1 PF04893.12 EDK38948.1 - 2.1e-10 40.3 16.6 3.4e-10 39.7 11.4 1.4 1 1 0 1 1 1 1 Yip1 domain tRNA-synt_1g PF09334.6 EDK38949.2 - 2.2e-118 395.3 0.6 4.5e-118 394.3 0.4 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EDK38949.2 - 5.6e-26 90.6 0.1 9.5e-11 40.4 0.0 4.0 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 EDK38949.2 - 3.1e-09 36.4 0.1 0.0011 18.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.8 EDK38949.2 - 0.00074 19.2 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA AAA PF00004.24 EDK38950.2 - 1.4e-50 170.8 0.0 5.2e-43 146.3 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 EDK38950.2 - 4.7e-07 29.8 1.0 6.5e-06 26.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 EDK38950.2 - 3.1e-06 27.2 0.2 3e-05 24.0 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain Bromodomain PF00439.20 EDK38950.2 - 2.2e-05 24.2 0.3 0.00013 21.7 0.1 2.4 2 0 0 2 2 2 1 Bromodomain AAA_22 PF13401.1 EDK38950.2 - 3.9e-05 23.8 0.8 0.0005 20.2 0.1 3.0 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 EDK38950.2 - 7.7e-05 22.1 0.0 0.00019 20.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 EDK38950.2 - 0.00015 21.4 0.1 0.00085 19.0 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EDK38950.2 - 0.0009 19.1 0.0 0.0063 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EDK38950.2 - 0.0036 17.0 0.1 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 EDK38950.2 - 0.004 17.0 0.0 0.015 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 EDK38950.2 - 0.0083 16.2 0.0 0.057 13.5 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.1 EDK38950.2 - 0.011 15.0 0.1 0.033 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 EDK38950.2 - 0.013 15.5 0.0 0.4 10.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.1 EDK38950.2 - 0.017 15.0 0.3 0.12 12.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.16 EDK38950.2 - 0.019 14.1 0.2 0.057 12.5 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 EDK38950.2 - 0.019 13.9 0.0 0.071 12.1 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_30 PF13604.1 EDK38950.2 - 0.024 14.2 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EDK38950.2 - 0.032 15.0 0.0 0.032 15.0 0.0 4.0 3 1 0 4 4 4 0 AAA domain AAA_3 PF07726.6 EDK38950.2 - 0.033 13.7 0.0 0.11 12.0 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK38950.2 - 0.042 13.3 0.1 0.77 9.2 0.0 2.9 3 1 0 3 3 3 0 Sigma-54 interaction domain PhoH PF02562.11 EDK38950.2 - 0.079 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.22 EDK38950.2 - 0.14 12.4 0.0 0.14 12.4 0.0 2.6 3 1 0 3 3 1 0 ABC transporter ResIII PF04851.10 EDK38950.2 - 0.17 11.7 0.0 0.17 11.7 0.0 2.7 2 1 0 2 2 1 0 Type III restriction enzyme, res subunit Spt4 PF06093.8 EDK38951.1 - 3.9e-31 106.7 0.0 4.7e-31 106.4 0.0 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RNHCP PF12647.2 EDK38951.1 - 0.046 13.5 0.5 0.059 13.2 0.3 1.2 1 0 0 1 1 1 0 RNHCP domain RNA_POL_M_15KD PF02150.11 EDK38951.1 - 0.061 13.0 1.4 0.8 9.4 0.6 2.2 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.7 EDK38951.1 - 0.11 11.8 0.5 0.62 9.4 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding 60KD_IMP PF02096.15 EDK38952.2 - 2.9e-24 85.8 9.6 9e-23 80.9 6.7 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein Gemini_AL1_M PF08283.6 EDK38953.2 - 0.0053 16.5 0.3 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 Geminivirus rep protein central domain HHH PF00633.18 EDK38953.2 - 0.012 15.2 0.0 0.034 13.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif SPRY PF00622.23 EDK38954.2 - 0.0051 16.8 0.3 0.02 14.9 0.0 2.0 2 0 0 2 2 2 1 SPRY domain Kdo PF06293.9 EDK38955.2 - 5.5e-09 35.3 0.0 8.9e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 EDK38955.2 - 1.3e-07 31.0 0.0 1.5e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 EDK38955.2 - 1.2e-06 27.9 0.0 2.8e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 EDK38955.2 - 3.1e-06 27.1 0.0 0.0011 18.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 EDK38955.2 - 0.0005 19.2 0.0 0.00057 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.15 EDK38955.2 - 0.0036 16.4 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 EDK38955.2 - 0.0062 16.1 0.1 0.011 15.2 0.1 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase WaaY PF06176.6 EDK38955.2 - 0.074 12.2 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) MARVEL PF01284.18 EDK38957.1 - 3.5e-22 78.7 20.5 4.7e-22 78.3 14.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain PHO4 PF01384.15 EDK38957.1 - 0.49 8.9 8.4 0.27 9.8 4.4 1.4 1 1 0 1 1 1 0 Phosphate transporter family YlaC PF10777.4 EDK38957.1 - 2.8 7.4 4.5 8.3 5.9 0.0 2.1 2 0 0 2 2 2 0 Inner membrane protein YlaC Ribonuclease_T2 PF00445.13 EDK38958.2 - 9.4e-45 152.5 4.1 2e-44 151.4 2.8 1.5 1 0 0 1 1 1 1 Ribonuclease T2 family AdoHcyase PF05221.12 EDK38959.1 - 1.2e-136 453.9 0.0 1.4e-136 453.7 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 EDK38959.1 - 4e-83 277.1 2.8 6.1e-83 276.5 1.9 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 EDK38959.1 - 6.4e-07 28.6 0.1 2e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 EDK38959.1 - 0.01 15.1 0.1 0.018 14.3 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain ELFV_dehydrog PF00208.16 EDK38959.1 - 0.018 14.6 0.1 0.048 13.2 0.1 1.7 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.13 EDK38959.1 - 0.051 13.5 0.1 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain TMEM107 PF14995.1 EDK38959.1 - 0.089 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein GATA PF00320.22 EDK38960.2 - 2.8e-16 58.5 3.8 5.9e-16 57.5 2.6 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 EDK38960.2 - 0.15 11.4 0.8 0.28 10.5 0.5 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding IF4E PF01652.13 EDK38961.2 - 7.1e-42 142.7 0.1 1.2e-41 142.0 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RibD_C PF01872.12 EDK38961.2 - 0.049 13.2 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 RibD C-terminal domain Peptidase_M20 PF01546.23 EDK38962.1 - 2.7e-30 105.2 0.0 5.2e-30 104.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK38962.1 - 6.6e-13 48.3 0.0 1.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain HAD_2 PF13419.1 EDK38963.2 - 2.8e-24 86.3 1.1 3.7e-24 85.8 0.7 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase FSH1 PF03959.8 EDK38964.1 - 3e-67 226.1 0.0 3.6e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 EDK38964.1 - 1.1e-06 28.4 0.0 2.1e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 EDK38964.1 - 0.00072 19.0 0.1 0.007 15.8 0.1 2.4 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 EDK38964.1 - 0.0041 17.0 0.0 1.8 8.4 0.0 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase family Thioredoxin PF00085.15 EDK38965.2 - 3.5e-23 81.2 0.7 2.3e-22 78.6 0.2 2.4 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK38965.2 - 5.7e-08 32.7 2.0 9.9e-07 28.8 0.1 3.2 2 2 1 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EDK38965.2 - 1.4e-05 25.2 0.9 6.5e-05 23.1 0.4 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.16 EDK38965.2 - 0.00044 19.9 0.4 0.0021 17.7 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 EDK38965.2 - 0.0026 17.3 0.2 0.0049 16.4 0.2 1.4 1 0 0 1 1 1 1 Redoxin TraF PF13728.1 EDK38965.2 - 0.03 13.8 0.0 0.03 13.8 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_9 PF14595.1 EDK38965.2 - 0.069 12.7 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin Peptidase_C12 PF01088.16 EDK38966.2 - 9.3e-64 214.5 0.0 1.3e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Scramblase PF03803.10 EDK38967.2 - 3e-62 209.5 0.0 4.1e-62 209.1 0.0 1.2 1 0 0 1 1 1 1 Scramblase Mito_carr PF00153.22 EDK38968.1 - 9e-69 227.2 0.8 5.9e-22 77.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Imm1 PF14430.1 EDK38968.1 - 0.15 12.1 0.0 0.37 10.9 0.0 1.6 2 0 0 2 2 2 0 Immunity protein Imm1 RRM_1 PF00076.17 EDK38969.2 - 1.9e-06 27.3 0.0 5.1e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK38969.2 - 2.8e-06 27.2 0.0 9.5e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_4 PF14392.1 EDK38969.2 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Zinc knuckle Arginase PF00491.16 EDK38970.1 - 4e-64 216.5 0.0 4.8e-64 216.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.12 EDK38971.2 - 5.3e-75 252.2 0.0 3.4e-74 249.5 0.0 2.2 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 EDK38971.2 - 3.6e-25 88.1 1.3 9.5e-07 29.0 0.1 4.9 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank PF00023.25 EDK38971.2 - 1.6e-19 68.6 6.1 0.00043 19.9 0.0 7.6 8 0 0 8 8 8 3 Ankyrin repeat Ank_4 PF13637.1 EDK38971.2 - 4.6e-19 68.3 2.5 2.7e-06 27.7 0.1 5.3 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK38971.2 - 1.3e-17 62.0 4.0 0.0077 16.3 0.0 7.9 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.1 EDK38971.2 - 1.3e-16 60.2 1.3 0.00048 20.2 0.0 5.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) SPX PF03105.14 EDK38971.2 - 2.6e-16 60.2 30.6 6e-13 49.1 5.1 4.2 3 1 1 4 4 4 2 SPX domain TIP41 PF04176.8 EDK38972.2 - 6.7e-75 250.3 0.0 8.7e-75 249.9 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family Sod_Fe_C PF02777.13 EDK38973.2 - 6e-16 58.1 0.1 4.2e-08 32.9 0.1 2.4 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain EnY2 PF10163.4 EDK38974.2 - 0.56 10.1 3.6 0.62 10.0 0.6 2.6 2 1 0 2 2 2 0 Transcription factor e(y)2 TPR_11 PF13414.1 EDK38975.2 - 1e-06 28.2 0.6 4.1e-05 23.1 0.4 2.5 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 EDK38975.2 - 0.00047 19.8 0.3 0.00047 19.8 0.2 4.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 EDK38975.2 - 0.00055 19.4 0.2 0.00055 19.4 0.1 2.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK38975.2 - 0.00078 20.0 0.1 0.022 15.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK38975.2 - 0.021 14.5 0.2 0.35 10.7 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat CTP_synth_N PF06418.9 EDK38976.1 - 4.3e-119 396.6 0.2 6.4e-119 396.1 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 EDK38976.1 - 4.2e-54 182.9 0.0 6.1e-54 182.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EDK38976.1 - 1.6e-07 31.0 0.0 3.8e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 EDK38976.1 - 0.022 14.1 0.0 0.063 12.6 0.0 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ESCRT-II PF05871.7 EDK38978.2 - 4.6e-40 136.7 0.0 6.7e-40 136.2 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit SCA7 PF08313.7 EDK38979.2 - 0.0089 15.6 0.6 0.0089 15.6 0.4 1.6 2 0 0 2 2 2 1 SCA7, zinc-binding domain REGB_T4 PF10715.4 EDK38979.2 - 0.011 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Endoribonuclease RegB T4-bacteriophage encoded SCHIP-1 PF10148.4 EDK38979.2 - 0.039 13.3 0.5 0.073 12.4 0.3 1.5 1 1 0 1 1 1 0 Schwannomin-interacting protein 1 LRR_4 PF12799.2 EDK38980.2 - 1.6e-12 46.7 12.0 0.056 13.0 0.0 7.5 5 2 2 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.2 EDK38980.2 - 4.5e-11 42.3 0.6 1.6e-10 40.5 0.5 2.0 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 EDK38980.2 - 1.1e-10 41.1 15.0 0.0031 17.2 0.0 6.8 4 3 3 7 7 7 6 Leucine rich repeat F-box PF00646.28 EDK38980.2 - 1.8e-06 27.4 0.9 7.6e-06 25.4 0.6 2.1 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.1 EDK38980.2 - 2.5e-06 26.9 15.8 23 5.4 0.0 10.7 12 0 0 12 12 12 0 Leucine Rich repeat PRANC PF09372.5 EDK38980.2 - 0.023 14.6 0.1 0.1 12.5 0.1 2.2 1 0 0 1 1 1 0 PRANC domain DMA PF03474.9 EDK38980.2 - 0.086 12.7 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 DMRTA motif LRR_1 PF00560.28 EDK38980.2 - 0.14 12.2 26.7 43 4.7 0.0 10.5 9 3 0 9 9 9 0 Leucine Rich Repeat CLAMP PF14769.1 EDK38980.2 - 0.15 12.2 0.4 34 4.6 0.0 3.6 3 0 0 3 3 3 0 Flagellar C1a complex subunit C1a-32 PUF PF00806.14 EDK38981.2 - 2e-25 86.7 0.4 4.3e-05 22.7 0.0 5.9 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat PCI PF01399.22 EDK38983.2 - 1.6e-15 57.3 0.6 8.7e-14 51.7 0.1 3.0 2 1 0 2 2 2 1 PCI domain eIF-5_eIF-2B PF01873.12 EDK38984.1 - 1.8e-41 140.7 0.1 7.4e-41 138.7 0.1 1.9 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.13 EDK38984.1 - 9.6e-29 99.1 3.7 3.2e-28 97.4 0.1 2.6 2 1 1 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Nudix_N_2 PF14803.1 EDK38984.1 - 0.066 12.9 1.4 0.15 11.7 1.0 1.5 1 0 0 1 1 1 0 Nudix N-terminal DNA_RNApol_7kD PF03604.8 EDK38984.1 - 0.29 10.6 2.1 0.55 9.7 1.5 1.5 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Npa1 PF11707.3 EDK38986.2 - 1e-60 205.5 9.0 1.3e-60 205.2 6.2 1.1 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal DUF4559 PF15112.1 EDK38986.2 - 0.033 13.3 0.0 0.088 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) Bul1_N PF04425.7 EDK38987.2 - 1.6e-52 178.5 11.8 1.8e-41 142.1 0.3 3.1 1 1 2 3 3 3 3 Bul1 N terminus Bul1_C PF04426.7 EDK38987.2 - 9.9e-06 24.9 5.7 0.0091 15.2 0.8 2.8 1 1 1 2 2 2 2 Bul1 C terminus GAS PF13851.1 EDK38987.2 - 0.017 14.3 0.2 0.017 14.3 0.1 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Pkinase PF00069.20 EDK38988.2 - 4.3e-64 216.1 0.2 6.5e-64 215.5 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK38988.2 - 8.9e-25 87.2 0.0 2e-24 86.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK38988.2 - 9.2e-05 21.5 0.0 0.083 11.8 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Sigma70_ner PF04546.8 EDK38988.2 - 1.9 8.0 6.5 1.3 8.6 3.0 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region ABC_tran PF00005.22 EDK38990.2 - 9.1e-39 132.8 0.2 4.4e-22 78.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.19 EDK38990.2 - 3.2e-22 78.7 16.0 5.1e-22 78.0 11.1 1.3 1 0 0 1 1 1 1 ABC-2 type transporter AAA_17 PF13207.1 EDK38990.2 - 9.7e-10 39.3 0.0 0.00043 21.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 EDK38990.2 - 1.4e-09 38.2 0.3 0.0022 18.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.1 EDK38990.2 - 3.1e-09 37.2 17.7 8.4e-09 35.7 1.5 3.7 4 1 0 4 4 3 2 AAA domain DUF258 PF03193.11 EDK38990.2 - 4e-09 35.8 0.3 0.0011 18.1 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK38990.2 - 1.6e-08 34.7 0.1 0.0021 18.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 EDK38990.2 - 1.8e-08 34.7 0.0 0.0054 17.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 EDK38990.2 - 6.1e-08 32.7 0.3 0.015 15.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EDK38990.2 - 2.1e-07 30.3 1.5 0.014 14.9 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SE PF00437.15 EDK38990.2 - 3.6e-07 29.3 1.4 0.0056 15.6 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein NACHT PF05729.7 EDK38990.2 - 5.3e-07 29.4 0.1 0.035 13.7 0.0 2.5 2 0 0 2 2 2 2 NACHT domain SMC_N PF02463.14 EDK38990.2 - 5.3e-07 29.0 2.0 0.0008 18.6 0.2 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain cobW PF02492.14 EDK38990.2 - 6.4e-07 28.9 0.9 0.011 15.1 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 EDK38990.2 - 2.6e-06 27.1 0.1 0.041 13.4 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Arch_ATPase PF01637.13 EDK38990.2 - 4.4e-06 26.5 4.1 0.0088 15.7 0.0 3.1 4 0 0 4 4 2 2 Archaeal ATPase MMR_HSR1 PF01926.18 EDK38990.2 - 4.5e-06 26.6 0.3 0.058 13.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_10 PF12846.2 EDK38990.2 - 4.8e-06 26.2 1.1 0.076 12.4 0.1 2.3 2 0 0 2 2 2 2 AAA-like domain MobB PF03205.9 EDK38990.2 - 6e-06 26.0 0.2 0.03 14.0 0.0 2.4 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EDK38990.2 - 7.3e-06 25.9 0.1 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 EDK38990.2 - 1.3e-05 25.3 0.1 0.21 11.7 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.1 EDK38990.2 - 2.3e-05 24.2 0.1 0.19 11.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.9 EDK38990.2 - 4.7e-05 23.1 0.1 0.074 12.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EDK38990.2 - 5e-05 22.9 0.1 0.16 11.7 0.0 2.4 2 0 0 2 2 2 2 Part of AAA domain AAA_30 PF13604.1 EDK38990.2 - 5.6e-05 22.8 0.0 0.18 11.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain NTPase_1 PF03266.10 EDK38990.2 - 9.5e-05 22.1 0.1 0.47 10.1 0.0 2.4 2 0 0 2 2 2 2 NTPase Pox_A32 PF04665.7 EDK38990.2 - 0.00011 21.5 0.3 0.17 11.1 0.1 2.3 2 0 0 2 2 2 2 Poxvirus A32 protein PduV-EutP PF10662.4 EDK38990.2 - 0.00012 21.5 0.1 0.42 10.0 0.0 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation PRK PF00485.13 EDK38990.2 - 0.00014 21.4 0.1 0.12 11.8 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.17 EDK38990.2 - 0.00019 20.9 0.8 0.34 10.3 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_24 PF13479.1 EDK38990.2 - 0.00022 20.8 0.5 0.31 10.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain UPF0079 PF02367.12 EDK38990.2 - 0.00037 20.1 0.4 0.088 12.4 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_15 PF13175.1 EDK38990.2 - 0.00041 19.5 0.3 0.00041 19.5 0.2 4.0 3 2 1 4 4 3 1 AAA ATPase domain AAA_25 PF13481.1 EDK38990.2 - 0.00056 19.3 0.1 0.45 9.8 0.1 2.7 3 0 0 3 3 2 1 AAA domain FtsK_SpoIIIE PF01580.13 EDK38990.2 - 0.00081 18.9 1.1 0.082 12.3 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Septin PF00735.13 EDK38990.2 - 0.0013 17.8 0.2 0.45 9.4 0.0 2.4 2 0 0 2 2 2 1 Septin ATP-synt_ab PF00006.20 EDK38990.2 - 0.0015 18.1 0.1 0.43 10.0 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Thymidylate_kin PF02223.12 EDK38990.2 - 0.0017 17.7 0.0 0.72 9.1 0.1 2.5 2 0 0 2 2 2 1 Thymidylate kinase AAA PF00004.24 EDK38990.2 - 0.0018 18.4 2.9 1.5 8.9 0.0 3.5 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 EDK38990.2 - 0.0019 18.0 0.2 0.011 15.5 0.0 2.4 2 1 0 2 2 1 1 Putative exonuclease SbcCD, C subunit DUF2075 PF09848.4 EDK38990.2 - 0.0032 16.5 0.1 1.7 7.5 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Miro PF08477.8 EDK38990.2 - 0.0037 17.7 0.1 3.3 8.2 0.0 2.9 2 0 0 2 2 2 0 Miro-like protein APS_kinase PF01583.15 EDK38990.2 - 0.0077 15.9 0.5 2.7 7.6 0.1 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase NB-ARC PF00931.17 EDK38990.2 - 0.0087 14.9 0.1 2.1 7.1 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain SRPRB PF09439.5 EDK38990.2 - 0.0089 15.2 2.9 1.1 8.3 0.0 2.7 3 0 0 3 3 2 1 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.16 EDK38990.2 - 0.0091 15.1 0.3 0.99 8.5 0.0 3.1 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EDK38990.2 - 0.011 14.8 0.1 3.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin KAP_NTPase PF07693.9 EDK38990.2 - 0.016 14.1 5.1 1.1 8.2 0.1 3.2 2 1 1 3 3 3 0 KAP family P-loop domain ArgK PF03308.11 EDK38990.2 - 0.017 13.8 0.2 1.2 7.7 0.0 2.2 2 0 0 2 2 2 0 ArgK protein FeoB_N PF02421.13 EDK38990.2 - 0.017 14.3 1.3 0.76 9.0 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B PIF1 PF05970.9 EDK38990.2 - 0.027 13.4 0.3 5.1 5.9 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase GTP_EFTU PF00009.22 EDK38990.2 - 0.028 13.8 0.0 6.6 6.1 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_23 PF13476.1 EDK38990.2 - 0.039 14.2 0.9 0.039 14.2 0.6 4.1 3 1 1 4 4 3 0 AAA domain TrwB_AAD_bind PF10412.4 EDK38990.2 - 0.048 12.2 1.2 0.66 8.5 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.12 EDK38990.2 - 0.061 13.1 8.9 0.47 10.2 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function DUF87 CbiA PF01656.18 EDK38990.2 - 0.11 11.9 0.5 3 7.1 0.1 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain TGF_beta_GS PF08515.7 EDK38990.2 - 0.88 8.9 4.6 2.4 7.5 0.1 2.5 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif ABC2_membrane_3 PF12698.2 EDK38990.2 - 5.3 5.9 16.9 1.1 8.1 8.1 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Dynamin_N PF00350.18 EDK38990.2 - 7.7 6.2 9.4 7.9 6.2 0.0 3.5 4 0 0 4 4 3 0 Dynamin family ABC_tran PF00005.22 EDK38991.2 - 4.3e-51 172.8 3.2 9.5e-25 87.4 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC2_membrane PF01061.19 EDK38991.2 - 2.1e-40 138.1 37.4 5.3e-23 81.2 8.6 2.5 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 EDK38991.2 - 3.5e-18 66.6 12.2 3.7e-08 33.6 2.3 4.5 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 EDK38991.2 - 1.4e-13 50.5 0.1 1.6e-05 24.2 0.0 3.0 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 EDK38991.2 - 4.8e-11 42.1 0.9 0.00017 20.7 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK38991.2 - 1.5e-10 41.4 0.8 0.00036 20.5 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 EDK38991.2 - 5.1e-10 39.6 2.9 0.0005 20.2 0.0 4.0 3 2 0 3 3 2 2 AAA domain AAA_15 PF13175.1 EDK38991.2 - 2e-09 36.9 3.4 0.096 11.7 0.0 4.2 4 0 0 4 4 4 3 AAA ATPase domain AAA_17 PF13207.1 EDK38991.2 - 8.3e-09 36.3 0.1 0.0056 17.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EDK38991.2 - 1.5e-08 33.9 0.2 0.0033 16.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 EDK38991.2 - 1.9e-08 34.9 0.4 0.00093 19.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 EDK38991.2 - 1.5e-06 27.7 0.1 0.27 10.5 0.0 3.5 3 0 0 3 3 3 2 AAA domain NACHT PF05729.7 EDK38991.2 - 2.6e-06 27.2 0.1 0.062 12.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain FtsK_SpoIIIE PF01580.13 EDK38991.2 - 2.8e-06 26.9 0.0 0.00057 19.4 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.2 EDK38991.2 - 3.3e-06 26.7 3.2 0.033 13.6 0.2 3.2 3 0 0 3 3 3 2 AAA-like domain RNA_helicase PF00910.17 EDK38991.2 - 8.9e-06 25.8 0.4 0.089 12.9 0.0 2.8 2 0 0 2 2 2 2 RNA helicase SbcCD_C PF13558.1 EDK38991.2 - 1.2e-05 25.1 2.6 0.11 12.4 0.0 3.9 3 2 0 3 3 2 2 Putative exonuclease SbcCD, C subunit AAA PF00004.24 EDK38991.2 - 1.4e-05 25.2 0.4 1.2 9.3 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 EDK38991.2 - 1.6e-05 24.7 0.0 0.06 13.0 0.0 2.6 2 0 0 2 2 2 2 Archaeal ATPase AAA_33 PF13671.1 EDK38991.2 - 1.6e-05 24.8 0.1 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 EDK38991.2 - 1.7e-05 25.0 4.4 0.037 14.3 0.0 3.2 4 0 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.18 EDK38991.2 - 2.6e-05 24.1 3.4 0.04 13.8 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase MobB PF03205.9 EDK38991.2 - 2.8e-05 23.8 0.0 0.22 11.2 0.0 2.9 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 EDK38991.2 - 4.1e-05 23.6 0.5 0.23 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 EDK38991.2 - 4.3e-05 23.2 0.1 0.28 10.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) T2SE PF00437.15 EDK38991.2 - 9.8e-05 21.3 0.0 0.28 10.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_14 PF13173.1 EDK38991.2 - 0.00015 21.7 0.9 0.98 9.3 0.0 3.8 4 0 0 4 4 3 1 AAA domain PRK PF00485.13 EDK38991.2 - 0.00048 19.7 0.5 0.12 11.8 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.1 EDK38991.2 - 0.00089 18.9 0.2 0.67 9.4 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.1 EDK38991.2 - 0.0013 18.3 0.2 1.9 8.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 EDK38991.2 - 0.0015 19.0 2.9 0.17 12.4 0.0 2.9 3 0 0 3 3 2 1 Miro-like protein Rad17 PF03215.10 EDK38991.2 - 0.0023 16.6 0.1 0.13 10.9 0.0 2.4 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 EDK38991.2 - 0.0032 17.1 0.0 2.2 8.1 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain Septin PF00735.13 EDK38991.2 - 0.0032 16.5 0.2 0.58 9.1 0.0 2.3 2 0 0 2 2 2 1 Septin KAP_NTPase PF07693.9 EDK38991.2 - 0.0037 16.2 0.0 0.91 8.4 0.0 2.3 2 0 0 2 2 2 1 KAP family P-loop domain cobW PF02492.14 EDK38991.2 - 0.006 16.0 1.5 1.7 8.0 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PDR_CDR PF06422.7 EDK38991.2 - 0.007 16.0 0.6 0.023 14.3 0.2 2.1 1 1 0 1 1 1 1 CDR ABC transporter DUF87 PF01935.12 EDK38991.2 - 0.008 16.0 8.1 0.59 9.9 0.0 3.0 3 0 0 3 3 2 2 Domain of unknown function DUF87 ATP_bind_1 PF03029.12 EDK38991.2 - 0.0081 15.7 0.2 3.4 7.1 0.1 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF815 PF05673.8 EDK38991.2 - 0.0092 14.9 0.4 2 7.3 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 EDK38991.2 - 0.015 14.3 0.0 0.99 8.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.12 EDK38991.2 - 0.017 14.5 0.0 32 3.8 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein Guanylate_kin PF00625.16 EDK38991.2 - 0.017 14.5 0.3 4.9 6.5 0.0 2.5 2 0 0 2 2 2 0 Guanylate kinase ArgK PF03308.11 EDK38991.2 - 0.023 13.4 0.1 4.5 5.9 0.0 2.5 2 0 0 2 2 2 0 ArgK protein Pox_A32 PF04665.7 EDK38991.2 - 0.026 13.8 0.4 3 7.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein NTPase_1 PF03266.10 EDK38991.2 - 0.032 13.9 0.6 2.2 7.9 0.1 3.1 3 0 0 3 3 3 0 NTPase SRPRB PF09439.5 EDK38991.2 - 0.033 13.3 0.9 4.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.13 EDK38991.2 - 0.067 12.7 0.2 12 5.2 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 EDK38991.2 - 0.069 12.7 0.1 2.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Dynamin_N PF00350.18 EDK38991.2 - 0.074 12.8 3.8 0.2 11.4 0.1 2.5 2 0 0 2 2 2 0 Dynamin family ATP-synt_ab PF00006.20 EDK38991.2 - 0.086 12.3 0.0 2.2 7.7 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF2075 PF09848.4 EDK38991.2 - 0.13 11.1 0.2 6.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.17 EDK38991.2 - 0.14 11.5 0.5 7.4 5.9 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.16 EDK38991.2 - 0.23 10.6 0.3 7.4 5.6 0.0 2.8 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI SurE PF01975.12 EDK38992.2 - 4.5e-46 156.6 0.0 6e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE PAP2 PF01569.16 EDK38993.2 - 5e-11 42.3 6.2 5e-11 42.3 4.3 2.4 2 1 1 3 3 3 1 PAP2 superfamily PAP2_C PF14360.1 EDK38993.2 - 0.00018 21.7 6.5 0.00018 21.7 4.5 4.1 5 1 0 5 5 5 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 EDK38993.2 - 0.00083 18.9 7.1 0.00083 18.9 4.9 1.7 2 0 0 2 2 2 1 PAP2 superfamily Mt_ATP-synt_D PF05873.7 EDK38994.2 - 5e-15 55.5 4.5 6.1e-15 55.2 3.1 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Vps51 PF08700.6 EDK38994.2 - 0.011 15.5 6.5 0.074 12.8 0.2 2.2 1 1 1 2 2 2 0 Vps51/Vps67 Serine_rich PF08824.5 EDK38994.2 - 0.026 14.2 0.5 0.035 13.8 0.3 1.2 1 0 0 1 1 1 0 Serine rich protein interaction domain DUF2205 PF10224.4 EDK38994.2 - 0.033 13.7 5.2 0.71 9.4 0.5 2.4 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Dor1 PF04124.7 EDK38994.2 - 0.039 12.4 2.5 0.045 12.2 1.7 1.1 1 0 0 1 1 1 0 Dor1-like family RNR_N PF08343.5 EDK38994.2 - 0.054 13.3 0.1 0.16 11.7 0.0 1.8 1 1 0 1 1 1 0 Ribonucleotide reductase N-terminal Peptidase_S64 PF08192.6 EDK38994.2 - 0.12 10.6 3.2 0.15 10.3 2.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF2408 PF10303.4 EDK38994.2 - 0.15 12.2 2.3 0.23 11.5 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) RelB PF04221.7 EDK38994.2 - 0.16 11.7 1.3 3.4 7.4 0.0 3.0 1 1 1 3 3 3 0 RelB antitoxin V_ATPase_I PF01496.14 EDK38994.2 - 0.16 9.7 5.6 0.19 9.5 3.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Aida_N PF08910.5 EDK38994.2 - 0.19 11.9 1.7 0.28 11.4 0.9 1.6 1 1 0 1 1 1 0 Aida N-terminus DUF4570 PF15134.1 EDK38994.2 - 0.25 11.2 3.1 0.84 9.5 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) Adaptin_N PF01602.15 EDK38995.2 - 6.5e-82 275.5 7.6 5.9e-66 222.8 1.3 2.1 2 0 0 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 EDK38995.2 - 1.5e-07 31.7 1.0 3e-07 30.7 0.7 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 EDK38995.2 - 0.0049 17.1 0.0 2.6 8.3 0.0 3.7 3 1 1 4 4 4 2 HEAT repeats Alpha_adaptin_C PF02296.11 EDK38995.2 - 0.0068 16.3 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain HEAT PF02985.17 EDK38995.2 - 0.027 14.5 4.7 37 4.7 0.1 4.8 4 0 0 4 4 4 0 HEAT repeat Arm PF00514.18 EDK38995.2 - 0.15 11.9 1.6 3.9 7.4 0.0 3.2 3 1 1 4 4 4 0 Armadillo/beta-catenin-like repeat CAP PF00188.21 EDK38996.2 - 1.3e-17 64.4 3.3 1.3e-17 64.4 2.3 1.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family PseudoU_synth_2 PF00849.17 EDK38997.2 - 4.5e-28 98.1 0.0 7.9e-28 97.3 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF4558 PF15104.1 EDK38997.2 - 0.081 12.8 0.1 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4558) WD40 PF00400.27 EDK38999.2 - 2.5e-17 62.0 0.0 8.5e-06 25.4 0.0 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EDK38999.2 - 0.074 11.3 0.0 0.42 8.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain SH3_1 PF00018.23 EDK39000.2 - 4.7e-11 41.8 0.1 4.7e-11 41.8 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EDK39000.2 - 1.5e-09 37.3 0.1 3.5e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK39000.2 - 2.4e-09 36.5 0.0 4.6e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Anoctamin PF04547.7 EDK39001.2 - 7.5e-92 308.3 14.8 1e-91 307.8 10.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Ala_racemase_N PF01168.15 EDK39002.2 - 3.1e-44 151.1 0.0 3.9e-44 150.8 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHQS PF01959.11 EDK39002.2 - 0.0099 14.5 0.4 0.05 12.2 0.0 2.0 2 0 0 2 2 2 1 3-dehydroquinate synthase (EC 4.6.1.3) La PF05383.12 EDK39003.1 - 6.9e-20 70.6 0.0 1.3e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 EDK39003.1 - 1.1e-05 24.9 0.0 0.13 11.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK39003.1 - 9.1e-05 22.3 0.0 0.00024 20.9 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PBP_sp32 PF07222.7 EDK39003.1 - 2.7 7.1 12.0 4.1 6.5 8.3 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Pol_alpha_B_N PF08418.5 EDK39004.2 - 2e-29 102.8 8.3 2.4e-29 102.6 5.7 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 EDK39005.2 - 5.3e-10 38.9 0.1 7.2e-10 38.4 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_E_B PF04042.11 EDK39006.2 - 1.4e-06 27.7 0.0 2.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B ResIII PF04851.10 EDK39007.2 - 5.8e-24 84.9 0.6 1.8e-23 83.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EDK39007.2 - 3.3e-14 52.4 0.1 1.4e-13 50.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK39007.2 - 6.6e-11 41.9 0.0 1.3e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.1 EDK39007.2 - 0.0018 18.1 0.1 0.015 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain GEMIN8 PF15348.1 EDK39007.2 - 7.9 6.4 9.6 2.6 8.0 1.4 2.3 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Peptidase_C13 PF01650.13 EDK39008.2 - 2.9e-47 161.1 0.5 4.3e-47 160.5 0.4 1.3 1 0 0 1 1 1 1 Peptidase C13 family CLASP_N PF12348.3 EDK39009.2 - 4e-88 294.6 13.6 2.6e-76 255.9 3.2 2.9 3 0 0 3 3 3 2 CLASP N terminal HEAT_2 PF13646.1 EDK39009.2 - 0.0061 16.8 0.1 5.4 7.3 0.0 3.8 2 1 0 2 2 2 1 HEAT repeats Arm PF00514.18 EDK39009.2 - 0.068 13.0 0.2 2.2 8.2 0.2 3.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 EDK39009.2 - 0.13 12.4 0.0 10 6.4 0.0 3.5 2 0 0 2 2 2 0 HEAT repeat STE PF02200.11 EDK39010.2 - 5.4e-58 193.8 2.4 1e-57 192.9 1.6 1.5 1 0 0 1 1 1 1 STE like transcription factor DUF3591 PF12157.3 EDK39012.2 - 1.9e-197 656.2 7.0 3.1e-197 655.4 4.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.1 EDK39012.2 - 1.7e-06 27.6 2.2 2.3e-06 27.1 0.6 2.0 2 0 0 2 2 2 1 Zinc knuckle Pkinase PF00069.20 EDK39013.2 - 2.3e-52 177.7 0.0 4.2e-52 176.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39013.2 - 8.6e-27 93.8 0.0 7e-26 90.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase SMC_Nse1 PF07574.8 EDK39013.2 - 0.0017 17.9 0.1 0.004 16.7 0.0 1.5 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex APH PF01636.18 EDK39013.2 - 0.049 13.3 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Thioredoxin_7 PF13899.1 EDK39014.2 - 2.7e-17 62.5 0.0 5.5e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 EDK39014.2 - 3.7e-11 42.9 0.0 1.2e-10 41.3 0.0 1.9 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 EDK39014.2 - 4.5e-11 42.0 0.1 1.7e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 UBA-like domain Thioredox_DsbH PF03190.10 EDK39014.2 - 0.018 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Toxin_67 PF15545.1 EDK39014.2 - 0.084 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative toxin 67 DUF2115 PF09888.4 EDK39015.2 - 0.034 14.2 9.7 0.15 12.1 0.6 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) PRESAN PF09687.5 EDK39015.2 - 0.073 13.1 4.0 0.053 13.5 1.0 2.1 2 0 0 2 2 2 0 Plasmodium RESA N-terminal ADIP PF11559.3 EDK39015.2 - 0.2 11.5 7.8 0.97 9.3 0.9 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3847 PF12958.2 EDK39015.2 - 1.5 8.6 5.3 10 5.9 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Sds3 PF08598.6 EDK39015.2 - 2.6 7.5 10.9 4 6.9 7.3 1.6 1 1 0 1 1 1 0 Sds3-like Skp1 PF01466.14 EDK39016.2 - 3.2e-36 123.2 2.3 1.2e-35 121.3 1.1 2.0 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 EDK39016.2 - 7.7e-19 67.5 0.1 1.8e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Peroxin-3 PF04882.7 EDK39017.2 - 1.3e-129 432.7 12.2 1.5e-129 432.5 8.5 1.0 1 0 0 1 1 1 1 Peroxin-3 XPC-binding PF09280.6 EDK39017.2 - 0.068 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 XPC-binding domain GRAM PF02893.15 EDK39018.2 - 2.1e-20 71.9 0.0 4.7e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Ribonuc_2-5A PF06479.7 EDK39019.2 - 8.3e-44 148.5 3.5 8.3e-44 148.5 2.4 1.9 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.20 EDK39019.2 - 3.3e-43 147.7 0.0 5.1e-43 147.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39019.2 - 6.9e-23 81.0 0.0 2.7e-22 79.1 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.16 EDK39019.2 - 0.0024 17.2 0.0 0.2 11.2 0.0 2.9 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.1 EDK39019.2 - 0.0053 16.2 0.0 0.044 13.2 0.0 2.4 1 1 0 1 1 1 1 PQQ-like domain Sas10_Utp3 PF04000.10 EDK39020.2 - 3.3e-16 59.2 0.9 8.8e-16 57.8 0.1 1.9 1 1 1 2 2 2 1 Sas10/Utp3/C1D family NPV_P10 PF05531.7 EDK39020.2 - 0.0015 18.7 0.5 1.2 9.4 0.1 2.3 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 EDK39020.2 - 0.12 12.3 2.8 4 7.3 0.1 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) XhlA PF10779.4 EDK39020.2 - 0.13 12.2 2.7 13 5.8 0.7 2.7 2 1 0 2 2 2 0 Haemolysin XhlA Nop25 PF09805.4 EDK39021.2 - 3.3e-41 140.5 22.3 3.3e-41 140.5 15.5 2.2 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) zf-SAP30 PF13866.1 EDK39021.2 - 0.011 15.4 1.8 0.033 13.8 1.3 1.8 1 0 0 1 1 1 0 SAP30 zinc-finger Creatinase_N PF01321.13 EDK39021.2 - 0.1 13.0 0.7 0.4 11.1 0.5 2.3 1 1 0 1 1 1 0 Creatinase/Prolidase N-terminal domain EcsC PF12787.2 EDK39021.2 - 0.27 10.5 4.5 0.48 9.7 0.2 2.4 2 0 0 2 2 2 0 EcsC protein family EXS PF03124.9 EDK39022.2 - 3.1e-69 233.6 13.7 3.8e-69 233.3 9.5 1.0 1 0 0 1 1 1 1 EXS family Ribonuclease_3 PF00636.21 EDK39024.2 - 6.3e-10 39.5 0.0 1.5e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 EDK39024.2 - 3.9e-06 26.8 0.0 0.00032 20.6 0.0 2.3 1 1 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 EDK39024.2 - 0.0011 19.4 0.0 0.0027 18.2 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif GARS_A PF01071.14 EDK39025.2 - 3.5e-80 268.1 0.0 7.4e-80 267.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 EDK39025.2 - 6.5e-35 119.5 0.9 1.6e-33 115.1 0.0 3.4 3 1 1 4 4 4 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 EDK39025.2 - 4.5e-32 111.1 0.0 8.6e-32 110.2 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 EDK39025.2 - 3.8e-27 94.2 0.8 9.3e-27 93.0 0.5 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 EDK39025.2 - 3e-16 59.4 2.7 1.1e-15 57.6 0.8 2.8 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATP-grasp_4 PF13535.1 EDK39025.2 - 1.9e-09 37.5 0.0 6.1e-09 35.8 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EDK39025.2 - 1.5e-07 30.5 0.0 4e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EDK39025.2 - 2.2e-06 27.1 0.0 4.9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EDK39025.2 - 2.8e-05 24.0 0.1 0.00015 21.7 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 EDK39025.2 - 3.2e-05 23.4 0.1 0.00042 19.8 0.0 2.7 2 0 0 2 2 2 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.12 EDK39025.2 - 0.0074 15.5 0.1 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain GCS PF03074.11 EDK39026.2 - 1.9e-134 448.4 0.3 1.6e-112 376.2 0.0 2.2 2 0 0 2 2 2 2 Glutamate-cysteine ligase GCS2 PF04107.8 EDK39026.2 - 0.047 12.7 0.0 0.095 11.7 0.0 1.4 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) adh_short PF00106.20 EDK39027.2 - 2.1e-27 96.0 0.0 2.9e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK39027.2 - 2.5e-15 56.9 0.0 3.6e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK39027.2 - 9.7e-09 35.1 0.0 1.7e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK39027.2 - 7.1e-06 26.1 0.0 1.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK39027.2 - 1.6e-05 24.5 0.0 0.00012 21.6 0.0 2.3 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 EDK39027.2 - 0.00055 19.6 0.3 0.0011 18.6 0.2 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1776 PF08643.5 EDK39027.2 - 0.019 14.1 0.0 0.57 9.2 0.0 2.5 2 1 1 3 3 3 0 Fungal family of unknown function (DUF1776) NmrA PF05368.8 EDK39027.2 - 0.092 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family DFP PF04127.10 EDK39027.2 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Sugar_tr PF00083.19 EDK39028.2 - 3.7e-64 216.9 22.8 4.6e-64 216.6 15.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39028.2 - 5.2e-25 87.9 23.4 5.2e-25 87.9 16.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily SMI1_KNR4 PF09346.5 EDK39029.2 - 1.3e-27 96.3 0.0 3.1e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Mitofilin PF09731.4 EDK39029.2 - 3.9 5.9 26.4 7.8 5.0 18.3 1.5 1 0 0 1 1 1 0 Mitochondrial inner membrane protein APC10 PF03256.11 EDK39030.2 - 2.3e-43 148.0 0.0 4.3e-42 143.8 0.0 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) QRPTase_C PF01729.14 EDK39031.2 - 6.7e-54 181.9 0.1 9.3e-54 181.4 0.1 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 EDK39031.2 - 1.1e-28 98.8 0.0 3.1e-28 97.3 0.0 1.8 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Acetyltransf_13 PF13880.1 EDK39032.2 - 7.4e-20 70.4 0.0 1.3e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 EDK39032.2 - 1.2e-08 34.3 2.7 3e-08 33.0 1.8 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.19 EDK39032.2 - 0.00022 21.2 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EDK39032.2 - 0.053 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 EDK39032.2 - 0.078 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Mito_carr PF00153.22 EDK39033.2 - 2.6e-34 116.7 5.7 2.9e-11 42.9 0.0 4.6 4 1 0 4 4 4 4 Mitochondrial carrier protein YajC PF02699.10 EDK39033.2 - 0.077 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit GIDA PF01134.17 EDK39035.2 - 1.1e-148 495.3 0.0 1.4e-148 494.9 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 EDK39035.2 - 1.2e-13 50.8 0.0 4.9e-13 48.9 0.0 2.1 2 0 0 2 2 2 1 GidA associated domain 3 Pyr_redox_2 PF07992.9 EDK39035.2 - 4e-05 23.5 0.8 9.9e-05 22.2 0.6 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EDK39035.2 - 0.00029 20.0 0.1 0.00041 19.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 EDK39035.2 - 0.0012 17.8 0.2 0.98 8.2 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK39035.2 - 0.013 14.3 0.9 0.022 13.6 0.6 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.22 EDK39035.2 - 0.017 15.5 0.0 0.052 13.9 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK39035.2 - 0.14 10.6 1.6 2.3 6.6 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein CMS1 PF14617.1 EDK39036.2 - 3.8e-29 101.4 10.2 5.6e-29 100.9 7.1 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.24 EDK39036.2 - 0.049 13.1 0.3 0.084 12.3 0.1 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase Vps51 PF08700.6 EDK39038.2 - 8.3e-11 41.5 0.1 8.3e-11 41.5 0.1 2.9 3 0 0 3 3 3 1 Vps51/Vps67 Zn_clus PF00172.13 EDK39039.2 - 3.6e-08 33.1 10.4 6e-08 32.4 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Synapsin_C PF02750.9 EDK39039.2 - 0.03 13.4 0.0 0.04 13.0 0.0 1.2 1 0 0 1 1 1 0 Synapsin, ATP binding domain Cse1 PF08506.5 EDK39040.2 - 7.3e-151 501.9 15.6 1.6e-150 500.7 10.8 1.6 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 EDK39040.2 - 1.5e-99 333.2 0.4 1.5e-99 333.2 0.3 2.5 2 1 1 3 3 3 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 EDK39040.2 - 3.3e-17 62.1 0.2 1.3e-14 53.8 0.0 4.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.17 EDK39040.2 - 0.086 12.9 0.8 19 5.6 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat UAA PF08449.6 EDK39041.1 - 4.4e-16 58.6 22.9 4.5e-16 58.6 15.4 1.3 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 EDK39041.1 - 2.5e-10 40.2 8.4 2.5e-10 40.2 5.8 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family PHO4 PF01384.15 EDK39041.1 - 2.8e-05 22.9 1.2 2.8e-05 22.9 0.8 2.6 2 1 0 2 2 2 2 Phosphate transporter family Cellulose_synt PF03552.9 EDK39041.1 - 0.00017 20.0 1.3 0.00032 19.1 0.9 1.4 1 0 0 1 1 1 1 Cellulose synthase EamA PF00892.15 EDK39041.1 - 0.0042 17.1 30.9 0.011 15.8 5.3 2.4 2 0 0 2 2 2 2 EamA-like transporter family GATase_2 PF00310.16 EDK39042.2 - 2.3e-26 92.3 0.1 4.3e-20 71.7 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 EDK39042.2 - 4.3e-16 59.0 0.0 8e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 EDK39042.2 - 3.4e-14 52.6 0.0 6.1e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 EDK39042.2 - 9.8e-12 44.6 0.1 1.6e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DEAD PF00270.24 EDK39043.1 - 1.2e-41 142.0 0.1 1.8e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39043.1 - 6.6e-25 86.7 0.0 1.2e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK39043.1 - 0.0009 19.1 0.1 0.065 13.0 0.1 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit EFG_C PF00679.19 EDK39044.2 - 1e-14 54.1 0.0 5.6e-14 51.7 0.0 2.3 3 0 0 3 3 3 1 Elongation factor G C-terminus EFG_II PF14492.1 EDK39044.2 - 1.6e-14 53.4 0.0 3.4e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 EDK39044.2 - 2e-09 37.4 0.1 4.8e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.13 EDK39044.2 - 0.0054 16.2 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV RuvB_C PF05491.8 EDK39044.2 - 0.031 13.9 0.0 0.077 12.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB C-terminus DUF3926 PF13080.1 EDK39044.2 - 0.089 12.3 0.3 0.24 10.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) Papo_T_antigen PF02380.10 EDK39045.2 - 0.043 13.7 0.1 0.077 12.9 0.1 1.4 1 0 0 1 1 1 0 T-antigen specific domain RNase_T PF00929.19 EDK39046.2 - 1.5e-16 61.1 0.0 2.3e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease Adenylsucc_synt PF00709.16 EDK39047.1 - 2.4e-168 560.1 0.0 2.8e-168 559.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Cupin_5 PF06172.6 EDK39048.1 - 0.096 12.5 0.0 2.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Cupin superfamily (DUF985) Iso_dh PF00180.15 EDK39049.1 - 2.3e-56 191.2 0.0 2.6e-56 191.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Complex1_LYR_2 PF13233.1 EDK39051.1 - 4.1e-21 75.4 0.4 4.9e-21 75.1 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like DSPc PF00782.15 EDK39052.2 - 0.0026 17.3 0.0 2.8 7.5 0.0 2.5 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain HTH_37 PF13744.1 EDK39052.2 - 0.15 11.8 0.0 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Hap4_Hap_bind PF10297.4 EDK39053.2 - 8.6e-08 31.7 10.5 8.6e-08 31.7 7.3 2.7 3 0 0 3 3 3 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DASH_Hsk3 PF08227.6 EDK39054.2 - 3e-22 78.5 2.9 3.9e-22 78.1 2.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Pet127 PF08634.5 EDK39054.2 - 0.0039 16.3 0.0 0.0042 16.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet127 IncA PF04156.9 EDK39054.2 - 0.077 12.5 0.2 0.091 12.3 0.1 1.1 1 0 0 1 1 1 0 IncA protein Cmc1 PF08583.5 EDK39055.1 - 6.7e-19 67.4 5.6 8.5e-19 67.0 3.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 EDK39055.1 - 0.12 12.3 1.8 0.24 11.3 0.9 1.8 1 1 0 1 1 1 0 CHCH domain Spc24 PF08286.6 EDK39056.2 - 1e-28 99.3 2.8 1e-28 99.3 2.0 1.9 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Myosin_tail_1 PF01576.14 EDK39056.2 - 0.0012 16.7 0.2 0.0012 16.7 0.2 1.8 2 0 0 2 2 2 1 Myosin tail DUF4140 PF13600.1 EDK39056.2 - 0.13 12.7 0.5 0.72 10.3 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Viral_P18 PF04521.8 EDK39056.2 - 0.17 11.3 3.6 3.1 7.2 0.2 2.2 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein V_ATPase_I PF01496.14 EDK39056.2 - 0.36 8.6 5.3 0.93 7.2 3.6 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Nbl1_Borealin_N PF10444.4 EDK39056.2 - 0.46 9.8 3.1 0.57 9.6 0.2 2.5 2 1 1 3 3 3 0 Nbl1 / Borealin N terminal TPR_MLP1_2 PF07926.7 EDK39056.2 - 0.94 9.2 6.3 1.2 8.8 0.6 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein L31 PF09784.4 EDK39057.2 - 1.7e-43 146.8 1.8 1.9e-43 146.6 1.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Ecl1 PF12855.2 EDK39058.2 - 3.2e-15 55.1 7.6 5e-15 54.4 5.3 1.3 1 0 0 1 1 1 1 Life-span regulatory factor zf-C2H2_jaz PF12171.3 EDK39058.2 - 0.081 13.1 0.9 0.081 13.1 0.7 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-MYND PF01753.13 EDK39058.2 - 0.33 10.8 5.2 0.69 9.8 3.6 1.5 1 0 0 1 1 1 0 MYND finger DAGK_prokar PF01219.14 EDK39059.1 - 0.016 14.8 1.7 0.06 12.9 0.1 2.0 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase YlaC PF10777.4 EDK39059.1 - 0.74 9.3 5.2 4.1 6.9 0.5 2.1 1 1 1 2 2 2 0 Inner membrane protein YlaC BCD PF15461.1 EDK39059.1 - 3.6 6.9 9.2 3.6 6.9 3.0 2.0 1 1 1 2 2 2 0 Beta-carotene 15,15'-dioxygenase PWI PF01480.12 EDK39061.2 - 3.3e-06 27.1 0.7 1e-05 25.5 0.5 1.9 1 0 0 1 1 1 1 PWI domain NRDE-2 PF08424.5 EDK39062.2 - 0.0074 15.2 0.1 0.0074 15.2 0.1 3.2 3 1 1 4 4 4 2 NRDE-2, necessary for RNA interference Suf PF05843.9 EDK39062.2 - 0.15 11.7 9.6 4.2 7.0 0.0 4.4 4 2 2 6 6 6 0 Suppressor of forked protein (Suf) C1_1 PF00130.17 EDK39063.2 - 0.013 15.2 0.2 0.025 14.3 0.1 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.2 EDK39063.2 - 0.21 11.4 1.8 0.32 10.8 0.4 1.9 2 0 0 2 2 2 0 Double zinc ribbon UBA PF00627.26 EDK39064.2 - 7.6e-22 76.5 1.0 5.9e-12 45.0 0.1 2.5 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.6 EDK39064.2 - 1.7e-18 65.8 2.0 3.1e-18 64.9 1.4 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.18 EDK39064.2 - 1.6e-13 49.8 0.7 3.7e-13 48.6 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 EDK39064.2 - 1e-05 25.3 0.1 1.8e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 EDK39064.2 - 0.00013 21.5 0.1 0.00029 20.4 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EDK39064.2 - 0.0022 18.1 0.1 0.005 17.0 0.1 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain YukD PF08817.5 EDK39064.2 - 0.11 13.0 0.5 0.31 11.6 0.0 1.9 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Serglycin PF04360.7 EDK39064.2 - 0.66 9.6 6.3 0.51 10.0 1.1 2.3 2 0 0 2 2 2 0 Serglycin HAD_2 PF13419.1 EDK39065.2 - 1.9e-17 64.0 0.0 2.5e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF3336 PF11815.3 EDK39066.2 - 9.6e-46 154.9 2.0 1.7e-45 154.0 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 EDK39066.2 - 1.3e-19 70.9 0.0 2.6e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase TPR_MLP1_2 PF07926.7 EDK39067.2 - 0.087 12.5 4.8 0.17 11.5 3.3 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Fungal_trans PF04082.13 EDK39068.2 - 4.4e-30 104.4 0.1 4.4e-30 104.4 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39068.2 - 2.6e-09 36.8 9.5 4.2e-09 36.1 6.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Suf PF05843.9 EDK39068.2 - 0.0035 17.1 2.0 0.0083 15.8 1.4 1.6 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Fungal_trans PF04082.13 EDK39069.2 - 3e-20 72.1 0.4 6.2e-20 71.1 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39069.2 - 3.2e-08 33.3 12.2 5.2e-08 32.6 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PALP PF00291.20 EDK39070.2 - 1.3e-59 201.9 0.6 2.1e-59 201.2 0.4 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GHMP_kinases_C PF08544.8 EDK39070.2 - 0.058 13.6 0.1 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 GHMP kinases C terminal PEX11 PF05648.9 EDK39072.2 - 7.9e-06 25.2 1.1 1.1e-05 24.8 0.8 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PEX11 PF05648.9 EDK39073.2 - 0.0045 16.2 0.0 0.02 14.1 0.0 1.9 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) UPF0104 PF03706.8 EDK39073.2 - 0.073 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Fumble PF03630.9 EDK39074.2 - 9.4e-117 389.6 1.3 2.8e-116 388.1 0.9 1.6 1 1 0 1 1 1 1 Fumble Peptidase_M1 PF01433.15 EDK39075.2 - 2.4e-80 270.5 0.0 3.9e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 EDK39075.2 - 1.8e-63 214.7 2.4 2.8e-63 214.1 1.6 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 EDK39075.2 - 7.1e-22 77.8 0.1 2e-21 76.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase MA superfamily ABC_tran PF00005.22 EDK39076.2 - 4.9e-34 117.5 0.0 9.2e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 EDK39076.2 - 1.4e-32 113.2 16.8 1.7e-32 112.9 11.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 EDK39076.2 - 4.1e-10 39.2 0.6 2.8e-07 29.9 0.4 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK39076.2 - 1.3e-09 38.4 0.0 0.0048 16.9 0.0 3.3 2 1 1 3 3 3 3 AAA domain AAA_16 PF13191.1 EDK39076.2 - 0.00023 21.2 0.1 0.00063 19.7 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK39076.2 - 0.00025 21.8 0.1 0.00081 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK39076.2 - 0.00079 18.9 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 EDK39076.2 - 0.0014 18.8 0.0 0.0066 16.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 EDK39076.2 - 0.0035 16.8 0.1 0.0068 15.8 0.1 1.5 1 1 0 1 1 1 1 AAA-like domain AAA_25 PF13481.1 EDK39076.2 - 0.0037 16.6 0.0 0.0092 15.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 EDK39076.2 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 EDK39076.2 - 0.016 14.8 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.7 EDK39076.2 - 0.017 14.2 0.2 0.055 12.6 0.0 1.9 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.1 EDK39076.2 - 0.024 14.9 0.1 0.079 13.2 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.1 EDK39076.2 - 0.034 14.0 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EDK39076.2 - 0.059 13.2 0.3 0.19 11.5 0.0 2.2 2 1 1 3 3 2 0 AAA domain DUF258 PF03193.11 EDK39076.2 - 0.064 12.4 0.0 0.19 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_19 PF13245.1 EDK39076.2 - 0.079 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain SbcCD_C PF13558.1 EDK39076.2 - 0.086 12.7 0.2 0.67 9.9 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF2951 PF11166.3 EDK39076.2 - 8 6.3 7.0 9.2 6.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) TPP_enzyme_M PF00205.17 EDK39077.2 - 2.6e-36 124.3 0.0 1e-34 119.2 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 EDK39077.2 - 2.5e-33 115.0 0.0 4.2e-33 114.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EDK39077.2 - 5e-12 45.6 0.0 1.3e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain OCC1 PF15506.1 EDK39077.2 - 0.038 13.8 0.2 10 6.0 0.0 2.7 2 0 0 2 2 2 0 OCC1 family TcpQ PF10671.4 EDK39077.2 - 0.046 13.6 0.0 0.16 11.8 0.0 1.9 1 0 0 1 1 1 0 Toxin co-regulated pilus biosynthesis protein Q HLH PF00010.21 EDK39078.2 - 2.2e-15 56.0 4.4 5.2e-15 54.8 3.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain BLIP PF07467.6 EDK39078.2 - 0.15 11.7 5.2 0.22 11.1 3.6 1.2 1 0 0 1 1 1 0 Beta-lactamase inhibitor (BLIP) Mcm10 PF09332.6 EDK39078.2 - 0.15 11.3 17.8 0.2 10.9 12.3 1.2 1 0 0 1 1 1 0 Mcm10 replication factor DUF3138 PF11336.3 EDK39078.2 - 0.28 9.3 5.9 0.36 8.9 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Cytochrome-c551 PF10643.4 EDK39078.2 - 0.47 9.7 4.8 0.83 8.8 0.9 2.0 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 DUF1635 PF07795.6 EDK39078.2 - 0.64 9.3 10.2 0.46 9.8 5.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) DUF2057 PF09829.4 EDK39078.2 - 0.94 9.1 17.5 0.21 11.2 9.4 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Ribosomal_60s PF00428.14 EDK39078.2 - 1.9 8.9 12.9 0.49 10.8 6.3 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein TFIIA PF03153.8 EDK39078.2 - 2.4 7.9 18.6 3.5 7.4 12.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LicD PF04991.8 EDK39079.2 - 3.6e-47 161.1 0.2 3.6e-47 161.1 0.1 2.7 2 1 0 2 2 2 1 LicD family Xan_ur_permease PF00860.15 EDK39080.1 - 5.2e-70 235.8 28.6 1e-69 234.8 19.8 1.4 1 1 0 1 1 1 1 Permease family DUF4029 PF13221.1 EDK39080.1 - 0.055 13.8 0.2 0.17 12.2 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4029) PEX11 PF05648.9 EDK39081.2 - 0.00029 20.1 2.8 0.069 12.4 0.0 3.1 2 1 1 3 3 3 3 Peroxisomal biogenesis factor 11 (PEX11) DUF2397 PF09660.5 EDK39081.2 - 0.06 11.9 0.1 0.078 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Mito_carr PF00153.22 EDK39082.2 - 2.8e-37 126.3 6.5 2.2e-19 68.9 0.2 2.9 2 1 1 3 3 3 2 Mitochondrial carrier protein CRF PF00473.12 EDK39082.2 - 0.14 12.2 0.1 3.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Corticotropin-releasing factor family MutL_C PF08676.6 EDK39083.2 - 1.8e-15 56.8 5.9 4.4e-15 55.5 3.2 2.4 2 1 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 EDK39083.2 - 6.7e-09 35.5 0.2 1.4e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 EDK39083.2 - 3.2e-08 33.2 0.1 7.4e-08 32.0 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hep_59 PF07052.6 EDK39084.2 - 0.0085 16.4 0.6 0.023 15.0 0.4 1.8 1 0 0 1 1 1 1 Hepatocellular carcinoma-associated antigen 59 NPCC PF08058.6 EDK39085.2 - 9.9e-41 138.9 0.1 1.6e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore complex component zf-C4H2 PF10146.4 EDK39085.2 - 3.2 7.6 5.4 1.4 8.9 0.1 2.3 2 1 0 2 2 2 0 Zinc finger-containing protein 4HBT_3 PF13622.1 EDK39086.1 - 1.9e-32 113.0 0.0 2.3e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EDK39086.1 - 2.3e-08 33.7 1.8 0.00014 21.4 0.2 3.3 3 1 1 4 4 4 2 Acyl-CoA thioesterase Recep_L_domain PF01030.19 EDK39087.2 - 3.7e-09 36.5 6.8 0.0055 16.6 0.1 4.0 2 1 1 3 3 3 3 Receptor L domain LRR_9 PF14580.1 EDK39087.2 - 0.087 12.3 0.2 0.27 10.7 0.1 2.0 2 0 0 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.1 EDK39087.2 - 0.37 10.5 5.7 14 5.5 0.2 4.2 2 1 1 3 3 3 0 Leucine rich repeat CTP_transf_2 PF01467.21 EDK39088.2 - 6.2e-07 29.6 0.0 1e-06 28.9 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase DUF4112 PF13430.1 EDK39091.2 - 4.4e-31 106.9 0.1 7e-31 106.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) HCV_core PF01542.13 EDK39091.2 - 0.066 13.6 0.3 0.36 11.2 0.1 2.0 1 1 1 2 2 2 0 Hepatitis C virus core protein Ank_2 PF12796.2 EDK39092.2 - 2e-45 153.0 5.8 1e-14 54.6 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) zf-DHHC PF01529.15 EDK39092.2 - 1.1e-27 96.4 4.5 1.1e-27 96.4 3.1 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.1 EDK39092.2 - 1.6e-25 88.9 5.9 7.1e-07 29.5 0.1 5.1 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK39092.2 - 3.3e-23 79.4 2.7 0.00017 21.5 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.25 EDK39092.2 - 4.7e-23 79.7 12.1 4.3e-06 26.2 0.0 6.8 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.1 EDK39092.2 - 6.2e-22 77.1 6.3 3.9e-06 26.9 1.4 5.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) RNase_T PF00929.19 EDK39093.2 - 3.5e-17 63.1 0.0 6.1e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 EDK39093.2 - 0.0075 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease CHORD PF04968.7 EDK39093.2 - 0.042 14.0 7.4 0.094 12.9 5.1 1.6 1 0 0 1 1 1 0 CHORD MutS_V PF00488.16 EDK39095.2 - 1.1e-73 247.5 0.0 1.7e-73 246.9 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 EDK39095.2 - 1.1e-40 139.5 0.0 2e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 EDK39095.2 - 5e-31 107.0 0.0 1.4e-30 105.6 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 EDK39095.2 - 1.4e-16 60.8 0.0 5.9e-16 58.7 0.0 2.0 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 EDK39095.2 - 1.7e-13 50.5 0.7 4.6e-13 49.1 0.5 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.1 EDK39095.2 - 0.0062 16.0 0.0 0.016 14.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4149 PF13664.1 EDK39096.2 - 3.1e-22 78.5 0.8 2.6e-21 75.5 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF2062 PF09835.4 EDK39096.2 - 0.032 13.8 0.1 2.2 7.8 0.0 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) LANC_like PF05147.8 EDK39096.2 - 0.036 12.6 0.1 0.044 12.3 0.1 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein zf-C2H2 PF00096.21 EDK39097.2 - 4.7e-09 36.0 9.8 0.00041 20.5 1.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK39097.2 - 2.6e-06 27.4 9.0 7.2e-06 26.0 2.8 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK39097.2 - 2e-05 24.5 10.7 0.032 14.5 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 EDK39097.2 - 0.0071 16.5 1.6 1.4 9.1 0.0 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EDK39097.2 - 0.056 13.3 5.6 0.87 9.5 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK39097.2 - 0.13 12.4 0.9 12 6.1 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Glutaredoxin PF00462.19 EDK39098.2 - 1.2e-19 70.0 0.0 5.4e-18 64.7 0.0 2.5 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.15 EDK39098.2 - 1.2e-14 53.8 0.0 3.8e-14 52.2 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK39098.2 - 2.6e-06 27.4 0.1 0.0016 18.5 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like Phosducin PF02114.11 EDK39098.2 - 0.0042 15.8 0.0 0.0065 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosducin ArsC PF03960.10 EDK39098.2 - 0.0053 16.8 0.0 0.16 12.0 0.0 2.4 2 0 0 2 2 2 1 ArsC family Thioredoxin_2 PF13098.1 EDK39098.2 - 0.0072 16.5 0.0 0.11 12.7 0.0 2.6 2 2 1 3 3 3 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EDK39098.2 - 0.037 13.5 0.0 0.39 10.2 0.0 2.3 2 1 0 2 2 2 0 Thioredoxin Rad17 PF03215.10 EDK39099.2 - 3e-12 46.0 3.3 1.1e-08 34.2 0.9 2.5 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein Rad17 PF03215.10 EDK39100.2 - 2.2e-37 128.9 0.0 3e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.24 EDK39100.2 - 0.001 19.2 0.0 0.0093 16.1 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK39100.2 - 0.0081 16.1 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain T2SE PF00437.15 EDK39100.2 - 0.013 14.3 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 EDK39100.2 - 0.018 15.1 0.0 0.047 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 EDK39100.2 - 0.046 14.5 0.1 0.12 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 EDK39100.2 - 0.099 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.1 EDK39100.2 - 0.14 11.7 0.1 0.31 10.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain Cor1 PF04803.7 EDK39100.2 - 0.24 11.1 1.1 0.38 10.5 0.7 1.3 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region JmjC PF02373.17 EDK39101.2 - 4.8e-41 139.5 0.6 4.8e-41 139.5 0.4 2.8 3 0 0 3 3 3 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.1 EDK39101.2 - 5.9e-13 48.7 8.0 1.9e-12 47.1 5.6 1.9 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.12 EDK39101.2 - 1e-12 47.3 0.5 2.7e-12 45.9 0.4 1.8 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H_2 PF13832.1 EDK39101.2 - 3.1e-10 40.0 6.0 1.1e-09 38.3 4.1 1.9 1 0 0 1 1 1 1 PHD-zinc-finger like domain Slx4 PF09494.5 EDK39102.2 - 2e-18 65.8 0.2 5.3e-18 64.5 0.1 1.7 1 0 0 1 1 1 1 Slx4 endonuclease CAF1A PF12253.3 EDK39103.2 - 2.5e-26 91.5 11.9 2.5e-26 91.5 8.3 4.1 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 EDK39103.2 - 2.8e-08 33.3 98.7 2.8e-08 33.3 68.4 2.8 2 1 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Sulfate_transp PF00916.15 EDK39104.2 - 2.5e-79 266.1 7.2 2.5e-79 266.1 5.0 1.7 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 EDK39104.2 - 1.7e-30 104.4 3.8 1.7e-30 104.4 2.6 3.6 4 0 0 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 EDK39104.2 - 1.2e-06 27.8 0.0 2.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 EDK39104.2 - 0.14 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 STAS domain FGGY_C PF02782.11 EDK39105.2 - 9.9e-55 185.2 0.4 3.2e-54 183.5 0.1 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 EDK39105.2 - 2.4e-23 82.7 0.0 6.9e-23 81.2 0.0 1.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.15 EDK39105.2 - 0.0085 15.4 0.0 0.059 12.6 0.0 2.2 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family CBFD_NFYB_HMF PF00808.18 EDK39106.2 - 1.2e-13 50.8 0.5 1.9e-13 50.2 0.4 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 EDK39106.2 - 3.7e-06 26.9 0.3 5.1e-06 26.5 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 MdcG PF10620.4 EDK39106.2 - 0.12 11.8 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG Trypan_PARP PF05887.6 EDK39106.2 - 0.13 12.1 3.1 0.2 11.4 2.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) tRNA_int_endo PF01974.12 EDK39107.2 - 1.3e-22 79.3 0.3 3.4e-22 78.0 0.0 1.8 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain APG6 PF04111.7 EDK39108.2 - 1.7e-93 313.1 9.4 2.4e-93 312.6 6.5 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 Med9 PF07544.8 EDK39108.2 - 0.046 13.4 4.8 0.16 11.7 3.3 2.0 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DDE_Tnp_ISL3 PF01610.12 EDK39108.2 - 6.1 6.3 8.9 11 5.5 6.2 1.4 1 1 0 1 1 1 0 Transposase EMP70 PF02990.11 EDK39109.2 - 1e-197 657.7 12.5 1.4e-197 657.3 8.7 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Zn_clus PF00172.13 EDK39110.2 - 7.2e-08 32.2 9.5 1.4e-07 31.3 6.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BTB_2 PF02214.17 EDK39111.2 - 5e-09 36.2 2.8 0.0013 18.8 0.1 3.5 3 1 0 3 3 3 2 BTB/POZ domain Fungal_trans_2 PF11951.3 EDK39112.2 - 2.3e-23 82.4 0.3 3e-23 82.0 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39112.2 - 4.8e-11 42.3 9.4 1.1e-10 41.2 6.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.18 EDK39113.2 - 6.3e-17 62.3 0.1 7.9e-17 62.0 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EDK39113.2 - 8.4e-05 22.1 0.5 0.0016 18.0 0.3 2.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase MFS_1 PF07690.11 EDK39114.2 - 1.7e-25 89.4 27.4 2.6e-25 88.8 19.0 1.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39114.2 - 5.4e-06 25.2 12.5 5.4e-06 25.2 8.7 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter PMP1_2 PF08114.6 EDK39114.2 - 0.048 13.1 0.8 0.13 11.7 0.6 1.7 1 0 0 1 1 1 0 ATPase proteolipid family ATP-synt_C PF00137.16 EDK39115.2 - 2.5e-26 91.3 32.8 1.1e-16 60.4 6.8 2.4 3 0 0 3 3 3 2 ATP synthase subunit C Sensor_TM1 PF13755.1 EDK39115.2 - 0.08 12.4 1.5 0.97 8.9 0.1 2.4 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain PC_rep PF01851.17 EDK39116.2 - 3.4e-24 83.6 12.4 1.1e-06 28.5 0.1 9.3 9 0 0 9 9 9 4 Proteasome/cyclosome repeat HEAT_2 PF13646.1 EDK39116.2 - 3.4e-05 24.0 0.1 0.51 10.6 0.0 3.8 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 EDK39116.2 - 0.039 14.4 0.0 3.1 8.4 0.0 3.6 2 1 1 3 3 3 0 HEAT-like repeat CENP-B_dimeris PF09026.5 EDK39116.2 - 9.9 6.4 12.7 2.8 8.2 0.7 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CRAL_TRIO_2 PF13716.1 EDK39117.2 - 2.2e-36 124.9 1.4 7.3e-36 123.3 1.0 1.8 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.22 EDK39117.2 - 1.4e-12 47.4 0.1 3e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PAE PF03283.8 EDK39117.2 - 0.025 13.2 0.0 0.041 12.5 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Intimin_C PF07979.6 EDK39117.2 - 0.09 12.9 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Intimin C-type lectin domain FAR1 PF03101.10 EDK39118.2 - 2e-06 28.1 1.5 2e-06 28.1 1.0 2.1 2 0 0 2 2 2 1 FAR1 DNA-binding domain AFT PF08731.6 EDK39118.2 - 3.4e-06 27.2 1.9 9.7e-06 25.7 0.1 2.6 2 1 0 2 2 2 1 Transcription factor AFT DBD_Tnp_Mut PF03108.10 EDK39118.2 - 0.00022 20.7 0.1 0.022 14.3 0.0 2.6 2 0 0 2 2 2 1 MuDR family transposase RPA_interact_C PF14768.1 EDK39118.2 - 1.5 9.2 5.1 18 5.8 0.1 2.6 2 0 0 2 2 2 0 Replication protein A interacting C-terminal NicO PF03824.11 EDK39118.2 - 5.8 6.1 6.0 11 5.1 4.2 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein Spermine_synth PF01564.12 EDK39120.2 - 1.9e-79 266.0 0.2 2.6e-79 265.6 0.2 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 EDK39120.2 - 0.0029 17.1 0.0 0.01 15.4 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK39120.2 - 0.018 15.6 0.0 0.03 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 EDK39120.2 - 0.15 11.4 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 zf-C2H2 PF00096.21 EDK39121.2 - 4.8e-06 26.5 17.7 3.5e-05 23.8 2.7 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK39121.2 - 0.00037 20.6 13.6 0.032 14.5 1.3 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK39121.2 - 0.005 17.0 13.8 0.0076 16.5 0.9 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.7 EDK39121.2 - 0.99 9.5 6.0 20 5.3 3.1 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 EDK39121.2 - 2.6 8.2 7.3 52 4.1 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Peptidase_S49_N PF08496.5 EDK39122.2 - 0.03 14.1 0.1 0.03 14.1 0.1 2.5 2 1 1 3 3 3 0 Peptidase family S49 N-terminal BrkDBD PF09607.5 EDK39122.2 - 0.061 12.8 0.7 0.12 11.9 0.5 1.5 1 0 0 1 1 1 0 Brinker DNA-binding domain DUF4604 PF15377.1 EDK39122.2 - 0.56 10.4 14.6 0.8 9.9 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RR_TM4-6 PF06459.7 EDK39122.2 - 0.57 10.0 9.8 0.79 9.5 6.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Herpes_DNAp_acc PF04929.7 EDK39122.2 - 0.85 8.5 8.2 0.34 9.8 4.1 1.4 2 0 0 2 2 2 0 Herpes DNA replication accessory factor ATAD4 PF15321.1 EDK39122.2 - 2 9.4 10.9 0.24 12.4 4.3 1.8 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 RNase_H2-Ydr279 PF09468.5 EDK39122.2 - 2.2 7.3 10.2 3.7 6.6 7.0 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) TPR_16 PF13432.1 EDK39123.2 - 1e-05 26.0 1.8 0.0067 17.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK39123.2 - 1.5e-05 25.1 2.1 1.1 10.1 0.0 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 EDK39123.2 - 0.00031 21.0 6.4 0.018 15.3 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK39123.2 - 0.018 14.6 4.0 0.76 9.4 0.0 3.2 3 1 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 EDK39123.2 - 0.025 14.4 0.0 11 6.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S6 PF01250.12 EDK39123.2 - 0.032 14.0 0.0 0.1 12.4 0.0 1.9 1 0 0 1 1 1 0 Ribosomal protein S6 TPR_17 PF13431.1 EDK39123.2 - 0.04 14.1 0.8 22 5.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Fungal_trans PF04082.13 EDK39124.2 - 3.6e-06 26.0 1.7 3e-05 23.0 1.2 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39124.2 - 0.0028 17.5 11.1 0.005 16.7 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.7 EDK39125.2 - 4e-52 177.3 32.1 4.5e-52 177.1 22.2 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.7 EDK39125.2 - 0.65 8.2 35.0 0.88 7.8 24.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Exonuc_VII_L PF02601.10 EDK39125.2 - 2.5 7.2 12.4 3.2 6.8 8.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit GIT_SHD PF08518.6 EDK39126.2 - 5.5e-25 86.4 6.6 4.1e-14 51.6 0.5 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Pentapeptide_4 PF13599.1 EDK39126.2 - 5.4 6.8 11.3 4.1 7.2 1.1 2.8 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) DEAD PF00270.24 EDK39127.2 - 3e-41 140.7 0.1 1.2e-40 138.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39127.2 - 1.5e-25 88.8 0.1 4.1e-25 87.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK39127.2 - 0.0012 18.6 0.0 0.0012 18.6 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EDK39127.2 - 0.009 16.1 0.1 0.046 13.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Ribonucleas_3_3 PF14622.1 EDK39128.2 - 5.3e-29 100.7 0.1 7e-29 100.3 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 EDK39128.2 - 7.6e-05 23.1 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain ATP-synt_G PF04718.10 EDK39129.1 - 4.5e-32 110.7 0.3 4.5e-32 110.7 0.2 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Serinc PF03348.10 EDK39130.2 - 6.2e-160 532.6 13.8 7e-160 532.4 9.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF3976 PF13121.1 EDK39130.2 - 0.63 9.9 5.1 0.14 12.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3976) PAXNEB PF05625.6 EDK39131.2 - 2.9e-118 394.8 0.1 3.2e-118 394.7 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein KaiC PF06745.8 EDK39131.2 - 0.046 12.8 0.1 0.46 9.5 0.0 2.2 2 1 0 2 2 2 0 KaiC MCM PF00493.18 EDK39132.2 - 3.1e-139 463.4 0.1 5.2e-139 462.6 0.1 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 EDK39132.2 - 1.2e-22 80.6 0.3 1.2e-22 80.6 0.2 2.8 3 1 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.9 EDK39132.2 - 2.6e-06 27.2 0.0 1e-05 25.2 0.0 2.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 EDK39132.2 - 3.8e-06 26.2 0.0 0.00022 20.4 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EDK39132.2 - 0.00013 21.5 0.0 0.0027 17.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK39132.2 - 0.043 13.3 0.2 3.7 7.0 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF1751 PF08551.5 EDK39134.1 - 4.5e-15 55.7 1.9 4.5e-15 55.7 1.3 2.4 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) YWFCY PF14293.1 EDK39134.1 - 1 9.2 5.8 0.13 12.1 0.4 2.1 2 0 0 2 2 2 0 YWFCY protein Rhomboid PF01694.17 EDK39134.1 - 1.1 9.2 10.3 0.054 13.5 3.0 1.8 2 0 0 2 2 2 0 Rhomboid family TRAPPC-Trs85 PF12739.2 EDK39135.2 - 2.5e-109 365.6 5.4 2.5e-109 365.6 3.7 1.7 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Rax2 PF12768.2 EDK39136.2 - 1.4e-87 293.5 0.9 1.4e-87 293.5 0.6 6.7 3 2 4 7 7 7 4 Cortical protein marker for cell polarity BNR PF02012.15 EDK39137.2 - 0.004 16.7 1.9 0.58 10.2 0.1 3.1 2 0 0 2 2 2 2 BNR/Asp-box repeat BNR PF02012.15 EDK39138.2 - 5.8e-10 37.4 37.6 0.0073 15.9 0.4 10.7 10 0 0 10 10 10 5 BNR/Asp-box repeat BNR_2 PF13088.1 EDK39138.2 - 0.00022 20.6 2.6 0.047 12.9 0.3 4.8 4 3 0 4 4 4 1 BNR repeat-like domain PSII_BNR PF14870.1 EDK39138.2 - 0.00073 18.6 2.5 3.8 6.4 0.1 4.7 3 2 1 4 4 4 1 Photosynthesis system II assembly factor YCF48 Frataxin_Cyay PF01491.11 EDK39138.2 - 0.035 13.9 0.0 0.22 11.3 0.0 2.4 2 0 0 2 2 2 0 Frataxin-like domain Mo-co_dimer PF03404.11 EDK39138.2 - 0.33 10.5 6.1 8.9 5.9 0.0 4.7 5 1 1 6 6 6 0 Mo-co oxidoreductase dimerisation domain FF PF01846.14 EDK39140.2 - 1.3e-27 95.5 17.7 7.5e-10 38.6 0.5 5.8 5 0 0 5 5 5 4 FF domain WW PF00397.21 EDK39140.2 - 3.4e-19 68.3 21.0 4e-10 39.3 4.7 2.7 2 0 0 2 2 2 2 WW domain DUF4047 PF13256.1 EDK39140.2 - 0.35 10.8 14.9 0.19 11.7 0.2 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4047) ARPC4 PF05856.7 EDK39141.1 - 3.8e-67 224.9 4.4 4.2e-67 224.7 3.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) P34-Arc PF04045.9 EDK39141.1 - 0.092 12.0 1.1 0.15 11.3 0.1 1.7 1 1 1 2 2 2 0 Arp2/3 complex, 34 kD subunit p34-Arc DUF3942 PF13078.1 EDK39141.1 - 0.21 11.6 4.0 0.68 10.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3942) Fungal_trans PF04082.13 EDK39142.2 - 1e-30 106.4 0.2 1e-30 106.4 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39142.2 - 2.9e-05 23.8 10.0 6.7e-05 22.7 6.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-DHHC PF01529.15 EDK39144.2 - 2.4e-32 111.6 12.7 2.4e-32 111.6 8.8 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase BCD PF15461.1 EDK39144.2 - 0.085 12.2 7.0 0.48 9.8 1.0 2.4 2 0 0 2 2 2 0 Beta-carotene 15,15'-dioxygenase TRM PF02005.11 EDK39146.2 - 2.3e-129 431.5 0.0 2.9e-129 431.2 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.11 EDK39146.2 - 0.00014 21.5 0.0 0.00039 20.0 0.0 1.7 1 0 0 1 1 1 1 Met-10+ like-protein DUF2067 PF09840.4 EDK39146.2 - 0.004 16.6 0.0 0.009 15.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) Thg1C PF14413.1 EDK39146.2 - 0.043 13.4 0.7 0.11 12.1 0.0 2.0 2 1 0 2 2 2 0 Thg1 C terminal domain CpXC PF14353.1 EDK39146.2 - 0.077 12.9 0.2 1 9.3 0.0 2.5 1 1 1 2 2 2 0 CpXC protein DUF2197 PF09963.4 EDK39146.2 - 0.094 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) DUF2763 PF10961.3 EDK39147.1 - 0.16 12.3 1.5 0.19 12.1 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) DUF3246 PF11596.3 EDK39147.1 - 1.9 7.7 7.3 2.4 7.3 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Chorion_3 PF05387.6 EDK39147.1 - 9.5 5.5 14.6 11 5.3 10.1 1.1 1 0 0 1 1 1 0 Chorion family 3 Epimerase PF01370.16 EDK39148.2 - 2.9e-16 59.6 0.0 5.8e-16 58.6 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK39148.2 - 7.5e-12 44.5 0.0 9.5e-12 44.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EDK39148.2 - 1.8e-09 36.9 0.1 0.00072 18.5 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 EDK39148.2 - 7.7e-09 35.8 0.1 1.3e-08 35.0 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 EDK39148.2 - 0.00012 21.4 0.1 0.016 14.4 0.1 2.2 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.10 EDK39148.2 - 0.0017 17.2 0.3 0.0026 16.6 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ELFV_dehydrog PF00208.16 EDK39148.2 - 0.013 15.1 0.1 0.027 14.0 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.20 EDK39148.2 - 0.022 14.6 0.1 0.081 12.8 0.0 1.9 2 0 0 2 2 2 0 short chain dehydrogenase Shikimate_DH PF01488.15 EDK39148.2 - 0.037 14.1 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.15 EDK39148.2 - 0.052 13.4 0.1 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Ydc2-catalyt PF09159.5 EDK39149.1 - 4.5e-48 164.0 0.6 7.6e-48 163.3 0.4 1.4 1 1 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.8 EDK39149.1 - 0.00085 19.2 0.3 6.4 6.6 0.0 3.3 3 0 0 3 3 3 2 Poxvirus A22 protein Flavoprotein PF02441.14 EDK39150.2 - 7.3e-41 138.8 1.6 1.3e-40 138.0 1.1 1.4 1 0 0 1 1 1 1 Flavoprotein CobT PF06213.7 EDK39150.2 - 1.2e-05 24.5 5.4 1.8e-05 23.9 3.7 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DUF2457 PF10446.4 EDK39150.2 - 0.00049 18.9 31.5 0.00049 18.9 21.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) Sigma70_ner PF04546.8 EDK39150.2 - 0.035 13.7 20.8 0.059 12.9 14.4 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Tim54 PF11711.3 EDK39150.2 - 0.073 11.6 0.5 0.13 10.7 0.4 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Utp14 PF04615.8 EDK39150.2 - 0.2 9.7 13.3 0.36 8.9 9.2 1.3 1 0 0 1 1 1 0 Utp14 protein BUD22 PF09073.5 EDK39150.2 - 0.78 8.7 17.2 1.7 7.5 11.9 1.5 1 0 0 1 1 1 0 BUD22 HSP90 PF00183.13 EDK39150.2 - 4.9 5.4 18.1 7.9 4.7 12.6 1.2 1 0 0 1 1 1 0 Hsp90 protein Vfa1 PF08432.5 EDK39150.2 - 8.5 6.3 15.0 4.5 7.2 8.6 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S24 PF00717.18 EDK39151.2 - 1.5e-08 34.1 0.1 2.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like M-factor PF03855.8 EDK39151.2 - 0.21 11.6 1.2 0.4 10.7 0.0 2.0 2 0 0 2 2 2 0 M-factor adh_short PF00106.20 EDK39152.2 - 3.8e-22 78.9 0.0 5.3e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK39152.2 - 1.2e-13 51.3 0.1 3.4e-13 49.9 0.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EDK39152.2 - 2.1e-06 27.8 0.0 3.6e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EDK39152.2 - 3.8e-06 26.7 0.1 5.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 EDK39152.2 - 0.011 14.8 0.0 0.1 11.6 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.10 EDK39152.2 - 0.015 14.8 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_7 PF13241.1 EDK39152.2 - 0.02 15.1 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Eno-Rase_NADH_b PF12242.3 EDK39152.2 - 0.043 13.6 0.1 0.087 12.6 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ApbA PF02558.11 EDK39152.2 - 0.073 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Epimerase PF01370.16 EDK39152.2 - 0.086 12.2 0.0 0.12 11.8 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.22 EDK39152.2 - 0.12 12.7 0.0 0.4 11.1 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Saccharop_dh PF03435.13 EDK39152.2 - 0.13 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF4208 PF13907.1 EDK39154.2 - 0.067 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) PRKCSH-like PF12999.2 EDK39155.2 - 2.3e-84 281.3 6.3 5.2e-84 280.1 4.3 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 EDK39155.2 - 3.1e-60 202.1 0.1 3.1e-60 202.1 0.1 2.2 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein HR1 PF02185.11 EDK39155.2 - 0.017 14.8 5.3 0.017 14.8 3.7 2.9 4 0 0 4 4 4 0 Hr1 repeat Pox_A_type_inc PF04508.7 EDK39155.2 - 0.25 11.2 4.9 1 9.3 0.1 3.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Fib_alpha PF08702.5 EDK39155.2 - 0.36 10.9 13.7 0.074 13.1 6.1 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family LUC7 PF03194.10 EDK39155.2 - 0.44 10.0 8.5 0.69 9.3 5.9 1.4 1 1 0 1 1 1 0 LUC7 N_terminus FliJ PF02050.11 EDK39155.2 - 0.48 10.4 10.0 0.31 11.1 4.2 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Phage_GPO PF05929.6 EDK39155.2 - 0.84 8.8 9.0 0.12 11.6 1.9 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase V_ATPase_I PF01496.14 EDK39155.2 - 8.4 4.1 11.8 9 4.0 7.5 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family BUD22 PF09073.5 EDK39156.2 - 3.7e-84 283.3 42.9 6.5e-61 206.7 16.8 2.4 1 1 1 2 2 2 2 BUD22 Trypan_PARP PF05887.6 EDK39156.2 - 4.4e-05 23.3 1.5 4.4e-05 23.3 1.0 1.9 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF3896 PF13035.1 EDK39156.2 - 6 6.9 12.8 0.16 12.0 1.6 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) TRM13 PF05206.9 EDK39157.2 - 7.5e-74 248.2 3.8 3e-71 239.7 2.7 2.1 1 1 0 1 1 1 1 Methyltransferase TRM13 Methyltransf_32 PF13679.1 EDK39157.2 - 0.00011 21.8 0.7 0.00022 20.9 0.5 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF3173 PF11372.3 EDK39157.2 - 0.013 15.1 0.1 2.6 7.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3173) TCTP PF00838.12 EDK39158.2 - 1.1e-71 240.1 1.5 1.3e-71 239.9 1.0 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein PTPA PF03095.10 EDK39158.2 - 0.069 12.3 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein GerPC PF10737.4 EDK39158.2 - 0.072 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Spore germination protein GerPC FGE-sulfatase PF03781.11 EDK39158.2 - 0.12 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 DPPIV_N PF00930.16 EDK39159.2 - 2.7e-103 345.2 10.3 4.9e-103 344.4 7.1 1.4 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EDK39159.2 - 1.8e-45 154.7 0.6 2.9e-45 154.1 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EDK39159.2 - 3.3e-07 30.1 0.0 1e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 EDK39159.2 - 0.00064 19.2 0.5 0.0015 18.0 0.1 1.8 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) LIP PF03583.9 EDK39159.2 - 0.0035 16.5 0.3 0.98 8.5 0.0 2.4 2 0 0 2 2 2 2 Secretory lipase Abhydrolase_2 PF02230.11 EDK39159.2 - 0.021 14.2 0.1 2.6 7.4 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DLH PF01738.13 EDK39159.2 - 0.085 12.1 0.0 0.26 10.5 0.0 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family HATPase_c PF02518.21 EDK39160.2 - 1.8e-26 92.0 0.1 9.3e-26 89.7 0.1 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EDK39160.2 - 2.5e-26 91.8 0.2 5.4e-26 90.8 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 EDK39160.2 - 3.6e-13 49.3 0.4 9.9e-13 47.8 0.2 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 EDK39160.2 - 0.019 15.1 0.1 0.019 15.1 0.0 2.5 2 1 0 2 2 2 0 HAMP domain Candida_ALS PF05792.8 EDK39161.2 - 0 1109.2 1109.5 9.3e-11 41.6 11.1 46.4 46 1 2 48 48 48 43 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.3 EDK39161.2 - 1.2e-84 283.0 6.9 2.6e-84 282.0 4.8 1.6 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding Hpr_kinase_C PF07475.7 EDK39161.2 - 0.015 14.6 4.6 6.1 6.1 0.0 7.0 7 3 3 10 10 10 0 HPr Serine kinase C-terminal domain Epimerase PF01370.16 EDK39163.2 - 8.4e-16 58.1 0.0 1.1e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK39163.2 - 1.5e-11 43.5 0.0 2e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK39163.2 - 5e-07 29.9 0.0 1.4e-06 28.4 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK39163.2 - 0.00011 21.2 0.1 0.0036 16.2 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EDK39163.2 - 0.02 14.1 0.1 0.2 10.9 0.0 2.1 2 0 0 2 2 2 0 NmrA-like family PINIT PF14324.1 EDK39164.2 - 0.11 12.5 0.2 0.4 10.7 0.0 1.9 2 1 0 2 2 2 0 PINIT domain Fungal_trans PF04082.13 EDK39165.2 - 3e-32 111.5 1.9 3.7e-32 111.2 1.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain SGL PF08450.7 EDK39166.1 - 1e-56 192.0 0.0 1.2e-56 191.8 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 EDK39166.1 - 0.00081 19.3 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 Strictosidine synthase NHL PF01436.16 EDK39166.1 - 0.0029 17.4 0.0 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 NHL repeat Arylesterase PF01731.15 EDK39166.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Arylesterase GFO_IDH_MocA PF01408.17 EDK39167.2 - 5.6e-05 23.6 0.0 0.00013 22.4 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EDK39167.2 - 0.00062 19.5 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain MFS_1 PF07690.11 EDK39168.1 - 4.5e-14 51.9 22.0 5.6e-14 51.6 15.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK39168.1 - 6.4e-11 41.9 14.6 8e-11 41.6 8.3 2.4 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 Bax1-I PF01027.15 EDK39168.1 - 0.14 11.7 21.3 6.5 6.2 14.8 2.1 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Sugar_tr PF00083.19 EDK39168.1 - 0.16 10.4 20.1 0.3 9.6 13.9 1.4 1 1 0 1 1 1 0 Sugar (and other) transporter DUF1109 PF06532.6 EDK39169.2 - 0.014 14.8 0.2 0.026 13.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1109) Abhydrolase_3 PF07859.8 EDK39170.2 - 0.0023 17.5 0.9 0.004 16.7 0.6 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 EDK39170.2 - 0.0096 14.6 0.1 0.022 13.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) COesterase PF00135.23 EDK39170.2 - 0.062 12.0 0.1 0.076 11.7 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family Abhydrolase_3 PF07859.8 EDK39171.2 - 9.8e-53 178.8 0.0 1.1e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EDK39171.2 - 0.0032 16.6 1.4 0.014 14.6 0.9 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Asp PF00026.18 EDK39172.2 - 1.3e-53 182.3 2.2 1.5e-53 182.0 1.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK39172.2 - 6.8e-05 22.8 0.0 0.00025 21.0 0.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EDK39172.2 - 0.00045 20.6 0.5 1.6 9.2 0.0 2.6 2 1 0 2 2 2 2 Aspartyl protease MFS_1 PF07690.11 EDK39173.2 - 1.8e-31 109.1 30.3 1.8e-31 109.1 21.0 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK39173.2 - 0.00027 19.2 1.1 0.00056 18.2 0.8 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF89 PF01937.14 EDK39173.2 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF89 Fungal_trans PF04082.13 EDK39174.2 - 3.8e-13 48.9 2.8 7.5e-13 47.9 1.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39174.2 - 2.1e-09 37.1 11.2 5.7e-09 35.7 7.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EDK39175.2 - 3.1e-29 101.8 40.8 3.1e-29 101.8 28.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39175.2 - 0.00029 19.5 17.4 0.00029 19.5 12.1 2.8 1 1 1 2 2 2 1 Sugar (and other) transporter 2-Hacid_dh_C PF02826.14 EDK39176.1 - 8.2e-44 148.8 0.0 2.9e-43 147.0 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EDK39176.1 - 3.4e-19 68.6 0.0 4.7e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.15 EDK39176.1 - 0.00019 21.5 0.2 0.094 12.8 0.0 3.0 2 1 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.10 EDK39176.1 - 0.0016 18.2 0.0 0.0045 16.8 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF4336 PF14234.1 EDK39177.2 - 0.00017 20.8 0.0 0.018 14.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) Lactamase_B PF00753.22 EDK39177.2 - 0.016 14.8 0.0 0.023 14.3 0.0 1.3 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily GST_N_3 PF13417.1 EDK39178.1 - 4.2e-13 49.3 0.0 7.4e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 EDK39178.1 - 4.3e-12 46.0 0.0 1.3e-11 44.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 EDK39178.1 - 3.7e-11 42.8 0.0 7.9e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EDK39178.1 - 2e-09 37.3 0.0 3.2e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.5 EDK39178.1 - 0.008 16.5 0.0 0.027 14.8 0.0 1.8 1 1 0 2 2 2 1 MetRS-N binding domain GST_C_2 PF13410.1 EDK39178.1 - 0.018 14.9 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EDK39178.1 - 0.091 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Hom_end PF05204.9 EDK39179.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Homing endonuclease Arylsulfotran_2 PF14269.1 EDK39180.2 - 0.11 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) cobW PF02492.14 EDK39181.1 - 1.2e-45 155.1 7.3 1.3e-43 148.4 5.1 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EDK39181.1 - 1.9e-19 69.1 0.0 2e-14 53.0 0.0 2.5 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.9 EDK39181.1 - 0.0039 16.8 0.6 0.016 14.9 0.1 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CDC45 PF02724.9 EDK39181.1 - 0.0044 15.1 7.3 0.0065 14.5 5.0 1.1 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.7 EDK39181.1 - 0.0063 15.8 6.4 0.0063 15.8 4.4 1.6 2 0 0 2 2 2 1 SDA1 Nop14 PF04147.7 EDK39181.1 - 0.0083 14.1 12.2 0.012 13.5 8.5 1.2 1 0 0 1 1 1 1 Nop14-like family ArgK PF03308.11 EDK39181.1 - 0.024 13.4 2.4 0.78 8.4 0.0 2.5 3 0 0 3 3 3 0 ArgK protein AAA_29 PF13555.1 EDK39181.1 - 0.064 12.7 0.1 0.16 11.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.13 EDK39181.1 - 0.064 12.7 0.9 0.31 10.5 0.1 2.4 2 1 1 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 EDK39181.1 - 0.069 13.4 0.1 0.069 13.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain NOA36 PF06524.7 EDK39181.1 - 0.073 12.3 8.3 0.13 11.5 5.8 1.3 1 0 0 1 1 1 0 NOA36 protein UPF0079 PF02367.12 EDK39181.1 - 0.075 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 EDK39181.1 - 0.087 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EDK39181.1 - 0.087 12.9 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 EDK39181.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Paf1 PF03985.8 EDK39181.1 - 0.75 8.4 12.9 1.2 7.8 8.9 1.2 1 0 0 1 1 1 0 Paf1 BUD22 PF09073.5 EDK39181.1 - 1.8 7.5 13.3 3.6 6.5 9.2 1.4 1 0 0 1 1 1 0 BUD22 CobT PF06213.7 EDK39181.1 - 3 6.9 16.9 5.1 6.1 11.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MFS_1 PF07690.11 EDK39182.2 - 5.9e-33 114.0 25.0 5.9e-33 114.0 17.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK39182.2 - 1.3 8.4 11.5 0.022 14.2 2.2 2.3 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 Fungal_trans PF04082.13 EDK39183.2 - 1.8e-68 230.2 1.4 2.7e-68 229.6 1.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EDK39183.2 - 4.5e-06 26.6 7.8 0.0009 19.4 1.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39183.2 - 2.6e-05 24.2 6.8 0.0034 17.6 0.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK39183.2 - 0.0083 16.3 0.3 0.0083 16.3 0.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain Abhydrolase_3 PF07859.8 EDK39185.1 - 6.9e-60 202.2 0.0 9.8e-60 201.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 EDK39185.1 - 3.1e-06 26.1 1.8 1.7e-05 23.7 1.3 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.16 EDK39185.1 - 9.3e-06 25.0 0.1 8.3e-05 21.9 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF2424 PF10340.4 EDK39185.1 - 0.0003 19.5 0.0 0.00047 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Esterase_phd PF10503.4 EDK39185.1 - 0.011 14.9 0.0 0.034 13.4 0.0 1.7 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_5 PF12695.2 EDK39185.1 - 0.053 13.2 0.0 0.21 11.3 0.0 1.9 1 1 1 2 2 2 0 Alpha/beta hydrolase family D-ser_dehydrat PF14031.1 EDK39186.2 - 2.5e-20 72.4 0.0 5.3e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 EDK39186.2 - 7.9e-13 48.4 0.2 1.1e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHDPS PF00701.17 EDK39189.2 - 3e-39 134.3 0.0 3.3e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family GreA_GreB_N PF03449.10 EDK39189.2 - 0.08 13.0 0.3 39 4.3 0.0 3.3 3 0 0 3 3 3 0 Transcription elongation factor, N-terminal Glyco_hydro_81 PF03639.8 EDK39190.2 - 4.7e-223 742.1 31.6 4.7e-223 742.1 21.9 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 Fer2_3 PF13085.1 EDK39191.2 - 2.4e-31 107.7 0.1 4.2e-31 107.0 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 EDK39191.2 - 2.5e-10 40.5 8.3 2.5e-10 40.5 5.8 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 EDK39191.2 - 9.3e-09 35.1 6.2 9.3e-09 35.1 4.3 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 EDK39191.2 - 3.2e-05 24.2 3.4 3.2e-05 24.2 2.3 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 EDK39191.2 - 0.00028 20.6 5.4 0.00028 20.6 3.7 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 EDK39191.2 - 0.00043 20.4 8.4 0.044 14.0 0.1 3.4 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.2 EDK39191.2 - 0.00083 19.6 5.4 0.00083 19.6 3.8 2.6 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 EDK39191.2 - 0.0021 17.7 4.0 0.0095 15.6 0.8 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_15 PF13459.1 EDK39191.2 - 1.1 9.8 7.5 1.6 9.3 0.1 2.8 3 0 0 3 3 3 0 4Fe-4S single cluster domain 2-Hacid_dh_C PF02826.14 EDK39192.2 - 1.6e-43 147.9 0.0 5.6e-43 146.1 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EDK39192.2 - 9.6e-20 70.4 0.0 1.4e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.15 EDK39192.2 - 0.00084 19.4 0.2 0.44 10.6 0.0 2.8 2 1 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Flo11 PF10182.4 EDK39193.2 - 2e-45 154.0 6.4 3.5e-45 153.2 4.4 1.4 1 0 0 1 1 1 1 Flo11 domain Dockerin_1 PF00404.13 EDK39193.2 - 1.2 8.9 8.2 68 3.4 0.0 6.1 8 0 0 8 8 8 0 Dockerin type I repeat TnpB_IS66 PF05717.8 EDK39195.2 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 IS66 Orf2 like protein FTH PF01827.22 EDK39196.2 - 0.028 14.0 4.9 1.2 8.7 0.4 3.1 2 1 1 3 3 3 0 FTH domain LRR_4 PF12799.2 EDK39196.2 - 4.2 7.1 31.2 0.54 9.9 6.4 6.6 6 1 1 7 7 7 0 Leucine Rich repeats (2 copies) Zn_clus PF00172.13 EDK39198.2 - 4.1e-08 32.9 11.2 4.1e-08 32.9 7.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.8 EDK39199.2 - 1.4e-67 227.5 11.3 1.4e-67 227.5 7.8 1.4 2 0 0 2 2 2 1 RTA1 like protein Bap31 PF05529.7 EDK39199.2 - 0.024 14.0 0.9 0.053 12.9 0.6 1.6 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Endonuc_BglI PF14562.1 EDK39199.2 - 0.025 13.4 0.2 0.041 12.7 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease BglI DUF2207 PF09972.4 EDK39199.2 - 0.29 9.6 11.0 0.21 10.1 4.1 3.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF1469 PF07332.6 EDK39199.2 - 2.8 7.7 8.0 3.9 7.2 0.1 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1469) DUF4341 PF14241.1 EDK39200.2 - 0.04 13.6 0.7 0.28 10.9 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4341) Sugar_tr PF00083.19 EDK39201.1 - 1.6e-29 102.7 11.0 2e-29 102.4 7.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39201.1 - 1.9e-12 46.5 13.7 1.9e-12 46.5 9.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily PAP2 PF01569.16 EDK39202.2 - 3.3e-19 68.8 0.7 3.3e-19 68.8 0.5 1.5 2 0 0 2 2 2 1 PAP2 superfamily Apc4 PF12896.2 EDK39202.2 - 0.051 12.8 0.1 0.082 12.1 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 S-AdoMet_synt_C PF02773.11 EDK39203.1 - 5.1e-77 256.2 0.2 1e-76 255.2 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 EDK39203.1 - 1.9e-47 160.1 0.0 3.4e-47 159.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 EDK39203.1 - 3.3e-43 145.9 0.2 7e-43 144.9 0.1 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain MRC1 PF09444.5 EDK39204.2 - 4.2e-40 137.4 14.3 4.2e-40 137.4 9.9 6.1 6 0 0 6 6 6 1 MRC1-like domain KH_1 PF00013.24 EDK39206.1 - 0.0087 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 EDK39206.1 - 0.017 14.7 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 KH domain KH_4 PF13083.1 EDK39206.1 - 0.091 12.4 0.1 0.36 10.4 0.0 2.0 2 0 0 2 2 2 0 KH domain Pkinase PF00069.20 EDK39207.2 - 4.1e-73 245.7 0.0 1.1e-72 244.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39207.2 - 1.6e-35 122.4 0.0 3.4e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39207.2 - 4.9e-05 22.4 0.0 0.0029 16.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK39207.2 - 0.0049 16.6 0.1 0.015 15.0 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF501 PF04417.7 EDK39207.2 - 4 7.2 6.9 1.2 8.9 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF501) EMG1 PF03587.9 EDK39209.1 - 9.8e-77 256.8 0.0 1.1e-76 256.6 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase LCD1 PF09798.4 EDK39210.2 - 1.9e-131 439.2 12.8 2.2e-131 439.0 8.9 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein DUF4600 PF15372.1 EDK39210.2 - 0.005 17.0 2.6 0.011 15.8 1.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) Macoilin PF09726.4 EDK39210.2 - 0.011 14.0 2.5 0.017 13.4 1.8 1.3 1 0 0 1 1 1 0 Transmembrane protein Myosin_tail_1 PF01576.14 EDK39210.2 - 0.027 12.2 5.9 0.037 11.7 4.1 1.1 1 0 0 1 1 1 0 Myosin tail TACC PF05010.9 EDK39210.2 - 0.03 14.0 1.3 0.045 13.5 0.9 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Spc7 PF08317.6 EDK39210.2 - 0.33 9.5 5.8 0.54 8.8 4.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF947 PF06102.7 EDK39210.2 - 0.54 10.0 2.8 1.3 8.8 1.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF947) Ribosomal_L37e PF01907.14 EDK39211.1 - 5.8e-28 96.4 11.1 5.8e-28 96.4 7.7 1.5 2 0 0 2 2 2 1 Ribosomal protein L37e DZR PF12773.2 EDK39211.1 - 0.00068 19.3 1.5 0.0011 18.7 1.1 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_6 PF14599.1 EDK39211.1 - 0.021 14.6 1.2 0.03 14.1 0.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon C1_1 PF00130.17 EDK39211.1 - 0.056 13.1 3.0 0.095 12.4 2.1 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SelR PF01641.13 EDK39211.1 - 0.087 12.5 0.3 0.12 12.1 0.2 1.4 1 1 0 1 1 1 0 SelR domain DUF1258 PF06869.7 EDK39211.1 - 0.097 11.7 0.4 0.1 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) zf-C3HC4_3 PF13920.1 EDK39211.1 - 0.17 11.5 2.9 0.22 11.1 2.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK39211.1 - 0.25 11.0 3.7 0.46 10.2 2.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain GATA PF00320.22 EDK39211.1 - 0.54 9.6 7.7 0.29 10.5 1.3 2.4 1 1 1 2 2 2 0 GATA zinc finger zf-ribbon_3 PF13248.1 EDK39211.1 - 0.56 9.4 4.8 2.3 7.5 3.3 1.9 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 EDK39211.1 - 1.8 8.1 4.8 11 5.5 0.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 EDK39211.1 - 2.1 8.4 6.3 3.3 7.8 4.3 1.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HYPF PF07503.7 EDK39211.1 - 5.2 6.5 8.0 18 4.8 3.5 2.7 2 1 1 3 3 3 0 HypF finger YhfH PF14149.1 EDK39211.1 - 6.1 6.7 6.2 4.6 7.1 0.7 2.3 1 1 1 2 2 2 0 YhfH-like protein Nucleo_P87 PF07267.6 EDK39212.2 - 0.031 12.9 2.5 0.035 12.8 1.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4083 PF13314.1 EDK39213.2 - 0.0081 15.9 0.9 0.0081 15.9 0.7 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4083) DUF3452 PF11934.3 EDK39213.2 - 0.013 14.7 2.0 0.26 10.6 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3452) DUF948 PF06103.6 EDK39213.2 - 1.6 8.6 15.6 1.9 8.3 1.2 4.7 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Mer2 PF09074.5 EDK39213.2 - 3.5 7.5 10.5 2.5 7.9 1.2 3.1 3 1 1 4 4 4 0 Mer2 Med10 PF09748.4 EDK39213.2 - 7.7 6.3 8.2 6.6 6.5 0.2 3.3 4 0 0 4 4 4 0 Transcription factor subunit Med10 of Mediator complex DUF835 PF05763.7 EDK39214.2 - 0.058 12.9 0.3 0.12 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF835) PRK PF00485.13 EDK39214.2 - 0.14 11.7 0.1 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family PAP2 PF01569.16 EDK39216.2 - 2.6e-21 75.6 1.0 2.6e-21 75.6 0.7 1.7 2 0 0 2 2 2 1 PAP2 superfamily SH3_9 PF14604.1 EDK39217.2 - 4e-06 26.3 0.1 1.4e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 EDK39217.2 - 3.6e-05 23.0 0.3 0.00032 20.0 0.2 2.3 1 1 0 1 1 1 1 SH3 domain DUF4448 PF14610.1 EDK39217.2 - 0.0029 17.1 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SH3_2 PF07653.12 EDK39217.2 - 0.018 14.4 0.1 0.081 12.4 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain DUF4177 PF13783.1 EDK39217.2 - 0.16 11.6 0.0 0.47 10.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) Presenilin PF01080.12 EDK39217.2 - 0.2 10.4 2.2 0.31 9.8 1.5 1.2 1 0 0 1 1 1 0 Presenilin PH PF00169.24 EDK39218.2 - 2.3e-07 30.9 0.2 0.00015 21.8 0.0 2.7 2 0 0 2 2 2 2 PH domain DUF605 PF04652.11 EDK39219.2 - 5e-48 164.3 2.4 6.1e-48 164.1 1.6 1.0 1 0 0 1 1 1 1 Vta1 like Nop25 PF09805.4 EDK39219.2 - 0.046 13.7 5.0 0.11 12.5 3.5 1.6 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Rpn3_C PF08375.6 EDK39219.2 - 1.4 9.4 12.7 0.64 10.4 5.1 3.0 3 1 0 3 3 3 0 Proteasome regulatory subunit C-terminal Sdh5 PF03937.11 EDK39220.2 - 4.7e-27 93.4 0.8 7.7e-27 92.8 0.6 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase EF-hand_7 PF13499.1 EDK39221.2 - 1.5e-16 60.2 10.0 5e-08 32.9 0.3 3.4 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 EDK39221.2 - 3.9e-16 57.4 3.1 4.7e-05 22.9 0.0 5.2 5 1 1 6 6 6 4 EF-hand domain EF-hand_1 PF00036.27 EDK39221.2 - 1.3e-13 49.1 5.6 2.2e-05 23.4 0.1 5.3 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.1 EDK39221.2 - 2.5e-08 33.3 1.6 0.00063 19.3 0.0 4.4 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 EDK39221.2 - 0.0073 16.1 1.4 1.1 9.2 0.1 3.7 2 1 1 3 3 3 1 EF-hand domain EF-hand_4 PF12763.2 EDK39221.2 - 0.048 13.3 0.2 0.12 12.1 0.1 1.8 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.1 EDK39221.2 - 0.053 12.8 10.9 3.9 6.9 0.1 5.4 6 0 0 6 6 6 0 EF hand EF-hand_2 PF09068.6 EDK39221.2 - 0.083 12.9 0.1 0.33 11.0 0.1 2.0 1 1 0 1 1 1 0 EF hand Ank_5 PF13857.1 EDK39222.2 - 7.1e-08 32.4 0.4 1.1e-05 25.5 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK39222.2 - 1.3e-07 31.7 0.1 2.6e-05 24.4 0.1 2.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) KilA-N PF04383.8 EDK39222.2 - 1.9e-06 27.4 0.0 4.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 KilA-N domain Ank PF00023.25 EDK39222.2 - 1e-05 25.0 0.6 0.029 14.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 EDK39222.2 - 3.2e-05 23.7 0.9 0.024 14.8 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 EDK39222.2 - 0.00023 21.6 0.3 4.3 7.9 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) zf-met PF12874.2 EDK39223.1 - 2.6e-06 27.4 0.9 9.3e-06 25.6 0.7 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EDK39223.1 - 0.034 14.2 0.2 0.096 12.8 0.2 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF3505 PF12013.3 EDK39223.1 - 0.041 14.1 0.0 0.067 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) PAPS_reduct PF01507.14 EDK39224.1 - 8e-18 64.8 0.1 7e-16 58.5 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family HLH PF00010.21 EDK39225.2 - 7.9e-17 60.7 0.0 1.8e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tom22 PF04281.8 EDK39225.2 - 0.013 14.9 0.7 0.024 14.1 0.5 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 DUF4085 PF13315.1 EDK39225.2 - 0.091 12.1 0.5 0.16 11.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Phage_mat-A PF03863.8 EDK39225.2 - 0.14 11.2 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Phage maturation protein SIR2 PF02146.12 EDK39227.2 - 7.7e-62 208.1 0.0 1.1e-61 207.6 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.8 EDK39227.2 - 7.3e-32 110.0 0.1 9.1e-15 54.5 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 EDK39227.2 - 5.7e-06 26.1 0.0 0.0033 17.1 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain CutC PF03932.9 EDK39227.2 - 0.1 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 CutC family DUF164 PF02591.10 EDK39227.2 - 7.2 6.5 7.3 6.7 6.6 3.2 2.3 2 1 0 2 2 2 0 Putative zinc ribbon domain CMAS PF02353.15 EDK39228.2 - 4.2e-63 212.9 0.5 5.1e-63 212.7 0.4 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 EDK39228.2 - 8.3e-15 54.8 0.0 1.5e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK39228.2 - 1.4e-05 25.4 0.0 2.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK39228.2 - 0.00049 19.7 0.0 0.00078 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK39228.2 - 0.00055 20.4 0.0 0.0015 19.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 EDK39228.2 - 0.002 18.1 0.4 0.0077 16.2 0.1 2.0 2 1 1 3 3 3 1 FtsJ-like methyltransferase Methyltransf_12 PF08242.7 EDK39228.2 - 0.0078 16.6 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain COX7C PF02935.11 EDK39228.2 - 0.0087 15.8 0.3 0.019 14.7 0.2 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Methyltransf_25 PF13649.1 EDK39228.2 - 0.014 15.7 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 EDK39228.2 - 0.019 14.3 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DOT1 PF08123.8 EDK39228.2 - 0.022 14.0 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 EDK39228.2 - 0.11 12.5 0.0 0.28 11.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Malate_synthase PF01274.17 EDK39229.1 - 5.7e-223 740.6 0.0 6.5e-223 740.4 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.9 EDK39229.1 - 0.054 12.3 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Glutaredoxin PF00462.19 EDK39230.2 - 7.6e-14 51.4 0.0 1.4e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Apc9 PF12856.2 EDK39231.2 - 3.5e-24 84.7 1.2 5.7e-24 84.1 0.0 2.0 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 9 Candida_ALS PF05792.8 EDK39232.2 - 9.1e-136 441.5 517.4 1.6e-10 40.8 14.3 18.7 19 0 0 19 19 19 16 Candida agglutinin-like (ALS) Candida_ALS_N PF11766.3 EDK39232.2 - 5.1e-95 317.1 12.1 8.3e-95 316.4 8.4 1.3 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding Pyr_redox_2 PF07992.9 EDK39233.2 - 3.1e-37 128.4 0.9 5e-37 127.7 0.6 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 EDK39233.2 - 4.6e-35 119.9 0.3 1.5e-34 118.3 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 EDK39233.2 - 3e-17 62.7 4.2 3.1e-14 53.1 0.2 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK39233.2 - 3.1e-08 33.9 0.0 8.3e-07 29.2 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EDK39233.2 - 4.5e-07 29.2 0.4 8.9e-07 28.3 0.3 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EDK39233.2 - 1.6e-06 26.8 2.3 0.0083 14.6 0.1 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.19 EDK39233.2 - 1.2e-05 24.3 3.5 0.0011 17.8 1.1 2.9 2 1 1 3 3 3 1 FAD binding domain K_oxygenase PF13434.1 EDK39233.2 - 3.8e-05 22.7 0.0 6.6e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.19 EDK39233.2 - 0.00017 20.5 5.8 0.0003 19.8 0.3 3.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.17 EDK39233.2 - 0.00045 19.2 0.5 0.00045 19.2 0.4 3.5 3 1 1 4 4 4 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 EDK39233.2 - 0.00046 20.1 0.5 0.00046 20.1 0.3 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EDK39233.2 - 0.0051 15.9 1.5 1 8.3 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain 2-Hacid_dh_C PF02826.14 EDK39233.2 - 0.006 15.7 0.4 1.6 7.8 0.0 3.2 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thi4 PF01946.12 EDK39233.2 - 0.017 14.2 0.3 0.059 12.4 0.0 2.0 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.16 EDK39233.2 - 0.022 14.3 0.2 0.63 9.5 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 EDK39233.2 - 0.034 13.8 2.7 0.55 9.8 0.1 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.1 EDK39233.2 - 0.74 9.5 4.6 8.3 6.1 0.0 3.1 3 1 0 3 3 3 0 FAD-NAD(P)-binding LSM PF01423.17 EDK39234.1 - 1.7e-12 46.7 0.6 2e-12 46.4 0.4 1.1 1 0 0 1 1 1 1 LSM domain Zn_clus PF00172.13 EDK39235.2 - 2.9e-09 36.6 6.2 8.6e-09 35.1 4.3 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YvfG PF09628.5 EDK39235.2 - 0.0054 16.8 0.2 0.02 15.0 0.1 2.0 1 0 0 1 1 1 1 YvfG protein Dickkopf_N PF04706.7 EDK39235.2 - 7.8 6.7 15.7 0.31 11.2 5.1 2.7 3 0 0 3 3 3 0 Dickkopf N-terminal cysteine-rich region ABC1 PF03109.11 EDK39236.2 - 3.3e-33 114.1 0.0 6.2e-33 113.2 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.17 EDK39236.2 - 0.0033 16.8 0.0 0.028 13.7 0.0 2.3 2 0 0 2 2 2 1 RIO1 family TSA PF03249.8 EDK39236.2 - 0.03 12.8 0.0 0.054 12.0 0.0 1.3 1 0 0 1 1 1 0 Type specific antigen Aa_trans PF01490.13 EDK39237.2 - 1.2e-75 254.5 28.0 1.4e-75 254.3 19.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3169 PF11368.3 EDK39237.2 - 1.6 7.9 12.2 0.076 12.2 0.4 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF3169) DUF4006 PF13179.1 EDK39237.2 - 3.3 7.3 5.9 4.6 6.8 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF4006) TIMELESS PF04821.9 EDK39238.2 - 2.3e-49 168.0 0.6 2.3e-49 168.0 0.4 2.3 2 0 0 2 2 2 1 Timeless protein DUF1533 PF07550.6 EDK39238.2 - 0.003 17.4 0.5 0.0091 15.9 0.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1533) DUF433 PF04255.9 EDK39238.2 - 0.046 13.1 0.1 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Zn_clus PF00172.13 EDK39239.2 - 4.3e-05 23.3 12.5 0.0001 22.1 8.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK39240.2 - 1.2e-13 50.5 0.0 2.3e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39240.2 - 5e-08 32.7 9.2 9.5e-08 31.8 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TSC22 PF01166.13 EDK39240.2 - 0.14 12.1 0.0 0.6 10.1 0.0 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family Cyclin_N PF00134.18 EDK39241.2 - 1.6e-18 66.4 0.0 2.4e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EDK39241.2 - 1.5e-10 41.6 0.2 3.4e-10 40.5 0.0 1.6 2 0 0 2 2 2 1 Cyclin Cmc1 PF08583.5 EDK39243.2 - 0.042 13.6 0.2 0.052 13.3 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like AMMECR1 PF01871.12 EDK39243.2 - 0.1 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 AMMECR1 TRP PF06011.7 EDK39244.2 - 5.8e-99 331.6 32.4 8.6e-99 331.0 22.4 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EDK39244.2 - 1.4e-05 25.1 3.4 0.059 13.3 0.4 2.4 2 0 0 2 2 2 2 ML-like domain SET PF00856.23 EDK39245.2 - 2.9e-11 43.9 0.0 1.5e-10 41.6 0.0 2.1 2 1 0 2 2 2 1 SET domain Clathrin-link PF09268.5 EDK39245.2 - 0.037 13.0 0.1 0.084 11.9 0.1 1.6 1 0 0 1 1 1 0 Clathrin, heavy-chain linker PQQ_3 PF13570.1 EDK39246.2 - 9.3e-05 22.5 1.2 0.043 14.1 0.1 4.0 4 0 0 4 4 4 1 PQQ-like domain PQQ_2 PF13360.1 EDK39246.2 - 0.00021 20.8 0.2 0.0012 18.3 0.1 2.2 2 1 0 2 2 2 1 PQQ-like domain WD40 PF00400.27 EDK39246.2 - 0.00052 19.7 0.1 0.11 12.4 0.0 3.5 3 0 0 3 3 3 1 WD domain, G-beta repeat Reg_prop PF07494.6 EDK39246.2 - 0.1 12.6 0.1 0.35 11.0 0.1 1.9 1 0 0 1 1 1 0 Two component regulator propeller DUF2462 PF09495.5 EDK39248.2 - 0.018 15.7 0.1 0.018 15.7 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2462) Pkinase PF00069.20 EDK39249.2 - 5.5e-45 153.5 0.0 9.6e-36 123.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39249.2 - 7e-18 64.6 0.0 2.1e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EDK39249.2 - 5.2e-05 22.3 0.2 0.22 10.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Med14 PF08638.6 EDK39250.2 - 4.9e-17 61.8 0.0 4.9e-16 58.5 0.0 2.4 2 0 0 2 2 2 1 Mediator complex subunit MED14 Zn_clus PF00172.13 EDK39252.2 - 1.3e-05 24.9 21.2 0.00015 21.5 7.4 2.5 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldose_epim PF01263.15 EDK39255.2 - 1.1e-40 139.6 0.2 1.3e-40 139.4 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase PAP2 PF01569.16 EDK39256.2 - 7.5e-13 48.2 9.2 7.5e-13 48.2 6.4 2.4 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 EDK39256.2 - 1.3e-07 31.3 6.8 1.3e-07 31.3 4.7 2.3 2 0 0 2 2 2 1 PAP2 superfamily Ribosomal_S6 PF01250.12 EDK39257.2 - 4.2e-10 39.3 0.0 5e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 APS_kinase PF01583.15 EDK39258.1 - 1.1e-72 242.8 0.0 1.3e-72 242.5 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 EDK39258.1 - 1.8e-07 31.1 0.0 4e-07 30.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EDK39258.1 - 1.8e-05 25.5 0.1 3.6e-05 24.5 0.1 1.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 EDK39258.1 - 2.3e-05 23.7 0.0 3.2e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 EDK39258.1 - 0.00024 21.3 0.2 0.0015 18.8 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_29 PF13555.1 EDK39258.1 - 0.0031 17.0 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.7 EDK39258.1 - 0.0049 15.9 0.0 0.0077 15.3 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_23 PF13476.1 EDK39258.1 - 0.017 15.4 0.1 0.031 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain CPT PF07931.7 EDK39258.1 - 0.045 13.3 0.1 0.74 9.4 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.1 EDK39258.1 - 0.072 13.0 0.2 0.11 12.4 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.18 EDK39258.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Snf7 PF03357.16 EDK39259.2 - 9.2e-30 103.2 21.9 9.2e-30 103.2 15.1 2.1 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.9 EDK39259.2 - 5.6e-05 22.6 4.1 9.2e-05 21.9 2.8 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway RNA_pol_Rpb2_45 PF10385.4 EDK39259.2 - 0.062 13.1 1.6 0.15 11.8 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Pollen_allerg_2 PF01620.11 EDK39259.2 - 0.3 11.4 2.6 0.57 10.4 1.8 1.4 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) DUF948 PF06103.6 EDK39259.2 - 3.9 7.3 9.6 0.55 10.1 1.9 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.17 EDK39259.2 - 6 6.9 18.5 0.19 11.7 6.5 2.8 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DAO PF01266.19 EDK39261.2 - 6.7e-15 54.8 0.0 7.5e-15 54.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Crl PF07417.7 EDK39261.2 - 0.0055 16.4 0.0 0.0086 15.7 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator Crl Cu-oxidase_3 PF07732.10 EDK39262.2 - 1.5e-45 153.7 4.0 3.9e-43 145.9 0.3 3.4 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 EDK39262.2 - 9.2e-43 145.0 12.5 2.4e-40 137.2 1.6 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 EDK39262.2 - 1.7e-32 112.5 1.8 6.2e-32 110.7 0.7 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.1 EDK39262.2 - 0.0093 15.8 0.0 39 4.1 0.0 3.6 3 0 0 3 3 3 0 Cupredoxin-like domain YlqD PF11068.3 EDK39264.2 - 0.36 10.8 22.0 0.036 14.1 10.5 2.5 1 1 1 2 2 2 0 YlqD protein DUF1192 PF06698.6 EDK39264.2 - 0.42 10.4 16.9 0.4 10.5 0.4 5.1 4 1 1 5 5 5 0 Protein of unknown function (DUF1192) ADIP PF11559.3 EDK39264.2 - 3.6 7.4 27.7 2.2 8.1 11.3 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.1 EDK39264.2 - 8 5.3 14.5 14 4.5 10.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Myb_DNA-binding PF00249.26 EDK39265.2 - 1.6e-19 69.6 8.2 1.5e-09 37.7 0.1 3.2 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK39265.2 - 4.1e-16 58.8 11.0 2.8e-13 49.7 1.3 3.9 3 1 1 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 EDK39265.2 - 2.5e-06 27.5 13.8 4.1e-06 26.8 2.1 3.7 2 1 1 3 3 3 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 EDK39265.2 - 0.24 11.5 13.3 0.89 9.7 1.6 4.3 2 1 2 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Sec5 PF15469.1 EDK39266.2 - 2.9e-40 137.9 11.2 2.9e-40 137.9 7.7 3.8 4 2 2 6 6 6 1 Exocyst complex component Sec5 Vps51 PF08700.6 EDK39266.2 - 2e-06 27.5 2.2 2e-06 27.5 1.5 2.9 2 0 0 2 2 2 1 Vps51/Vps67 FTR1 PF03239.9 EDK39267.2 - 1.1e-93 313.6 4.5 1.3e-93 313.3 3.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Ldr_toxin PF13940.1 EDK39267.2 - 0.92 9.3 5.8 0.14 11.9 0.5 2.3 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system MFS_1 PF07690.11 EDK39268.2 - 7e-36 123.6 35.8 7e-36 123.6 24.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39268.2 - 4.7e-12 45.2 6.9 4.7e-12 45.2 4.8 3.4 2 1 2 4 4 4 1 Sugar (and other) transporter Sybindin PF04099.7 EDK39268.2 - 0.078 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sybindin-like family TruB_N PF01509.13 EDK39270.2 - 3.9e-45 153.6 0.1 5.8e-44 149.8 0.0 2.3 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) DUF2023 PF09633.5 EDK39270.2 - 0.059 13.3 0.1 5.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2023) RRN3 PF05327.6 EDK39270.2 - 0.72 7.8 3.9 1.1 7.2 2.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Erf4 PF10256.4 EDK39271.2 - 1.9e-32 111.6 0.0 2.7e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF1331 PF07048.6 EDK39271.2 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) DUF3981 PF13139.1 EDK39272.2 - 0.27 11.2 3.2 0.29 11.1 1.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) DUF3087 PF11286.3 EDK39272.2 - 1.8 7.7 4.9 0.71 9.0 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3087) DUF2069 PF09842.4 EDK39273.2 - 0.01 15.7 0.2 0.042 13.7 0.0 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2069) PPR_3 PF13812.1 EDK39274.2 - 1.3e-18 65.6 0.2 0.052 13.8 0.0 8.0 8 1 0 8 8 8 5 Pentatricopeptide repeat domain PPR_2 PF13041.1 EDK39274.2 - 1.3e-16 60.3 16.7 8.4e-05 22.4 0.0 7.7 4 2 5 9 9 9 5 PPR repeat family PPR PF01535.15 EDK39274.2 - 6.4e-16 57.1 14.4 0.059 13.3 0.1 8.9 9 0 0 9 9 9 5 PPR repeat PPR_1 PF12854.2 EDK39274.2 - 5.1e-05 22.6 7.7 0.0059 16.0 0.0 5.5 6 0 0 6 6 6 2 PPR repeat RPM2 PF08579.6 EDK39274.2 - 0.00025 21.1 5.0 0.91 9.6 0.1 4.8 4 1 1 5 5 5 2 Mitochondrial ribonuclease P subunit (RPM2) Rep_fac_C PF08542.6 EDK39274.2 - 0.054 13.4 0.2 22 5.1 0.0 3.9 3 0 0 3 3 3 0 Replication factor C C-terminal domain Cyto_heme_lyase PF01265.12 EDK39275.2 - 1.8e-69 234.2 0.0 2e-69 234.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase OTU PF02338.14 EDK39276.2 - 7e-16 58.9 3.5 1.8e-15 57.5 0.0 2.5 3 0 0 3 3 3 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 EDK39276.2 - 5.2e-05 22.7 1.3 0.0014 18.0 0.0 2.5 2 1 1 3 3 3 2 Peptidase C65 Otubain Lge1 PF11488.3 EDK39276.2 - 1.6 8.9 10.1 0.05 13.7 1.7 2.5 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 AIF-MLS PF14962.1 EDK39276.2 - 2.4 7.7 9.1 3.7 7.1 6.3 1.3 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Cyclin_N PF00134.18 EDK39277.2 - 5.2e-36 123.0 1.2 9.1e-36 122.2 0.8 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.1 EDK39278.2 - 4.9e-50 170.3 0.1 1.2e-49 169.0 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 EDK39278.2 - 1.6e-06 27.6 0.0 0.00014 21.2 0.0 2.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 EDK39278.2 - 0.018 15.2 0.0 0.052 13.7 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.6 EDK39278.2 - 0.042 13.3 0.0 14 5.2 0.0 2.7 3 0 0 3 3 3 0 Cupin domain ARD PF03079.9 EDK39278.2 - 0.41 10.5 6.5 0.57 10.1 0.0 3.0 3 0 0 3 3 3 0 ARD/ARD' family Trypan_PARP PF05887.6 EDK39278.2 - 0.42 10.4 10.8 0.73 9.6 7.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4611 PF15387.1 EDK39278.2 - 0.51 10.5 13.2 0.41 10.8 5.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Daxx PF03344.10 EDK39278.2 - 6 5.2 14.2 9.9 4.4 9.8 1.3 1 0 0 1 1 1 0 Daxx Family ETF_QO PF05187.8 EDK39280.2 - 1.7e-37 127.8 0.0 2.9e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 EDK39280.2 - 2.7e-11 42.9 0.2 4.1e-05 22.6 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK39280.2 - 1.5e-10 40.5 0.3 0.00043 19.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.12 EDK39280.2 - 1.6e-06 27.3 0.2 0.0033 16.5 0.1 2.2 1 1 1 2 2 2 2 Thi4 family Pyr_redox PF00070.22 EDK39280.2 - 2.8e-06 27.6 0.2 0.057 13.8 0.0 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK39280.2 - 4e-06 26.7 0.0 9.4e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EDK39280.2 - 1.5e-05 23.6 0.0 5e-05 21.9 0.0 1.8 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.1 EDK39280.2 - 2e-05 24.7 0.0 4.9e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EDK39280.2 - 6.5e-05 22.9 0.0 0.00015 21.7 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 EDK39280.2 - 9.3e-05 21.6 0.0 0.00017 20.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EDK39280.2 - 0.00016 20.8 0.0 0.00042 19.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.9 EDK39280.2 - 0.00027 19.7 0.1 0.07 11.7 0.0 2.5 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EDK39280.2 - 0.00083 19.1 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.2 EDK39280.2 - 0.0099 16.2 0.8 0.027 14.8 0.5 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Lycopene_cycl PF05834.7 EDK39280.2 - 0.095 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_10 PF13237.1 EDK39280.2 - 0.099 12.4 0.6 0.2 11.4 0.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain RhoGEF PF00621.15 EDK39281.2 - 1.6e-35 122.6 0.0 2.7e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.6 EDK39281.2 - 1.7e-32 111.2 0.0 3.5e-32 110.2 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin PH_10 PF15411.1 EDK39281.2 - 9.1e-23 80.6 0.0 1.7e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.19 EDK39281.2 - 1.4e-06 27.8 0.0 6.3e-06 25.7 0.0 2.2 1 0 0 1 1 1 1 PB1 domain Pterin_bind PF00809.17 EDK39282.2 - 3.2e-57 193.3 0.1 1.1e-43 149.0 0.1 2.6 1 1 1 2 2 2 2 Pterin binding enzyme HPPK PF01288.15 EDK39282.2 - 8.5e-40 135.4 0.0 2.1e-39 134.1 0.0 1.7 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.13 EDK39282.2 - 2.7e-39 133.8 1.3 3.7e-19 68.9 0.2 2.6 2 0 0 2 2 2 2 Dihydroneopterin aldolase DUF77 PF01910.12 EDK39282.2 - 0.38 10.4 6.3 1.3 8.7 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function DUF77 RTC4 PF14474.1 EDK39283.2 - 1.4e-35 121.9 0.1 1.4e-35 121.9 0.1 1.8 2 0 0 2 2 2 1 RTC4-like domain RRM_6 PF14259.1 EDK39284.2 - 3.2e-06 27.0 0.0 6.3e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK39284.2 - 4.6e-05 22.9 0.0 7.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK39284.2 - 0.04 13.7 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.1 EDK39284.2 - 0.04 13.3 0.0 0.091 12.2 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein family 7 Esterase_phd PF10503.4 EDK39284.2 - 0.076 12.2 1.1 0.15 11.2 0.7 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase DUF1631 PF07793.6 EDK39284.2 - 0.19 9.8 0.7 0.32 9.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) CTD_bind PF04818.8 EDK39284.2 - 0.19 11.9 0.1 1.1 9.5 0.1 2.2 1 1 0 1 1 1 0 RNA polymerase II-binding domain. Peptidase_S21 PF00716.12 EDK39284.2 - 2.2 7.5 6.7 3.9 6.7 3.9 1.8 1 1 0 1 1 1 0 Assemblin (Peptidase family S21) MRP-L46 PF11788.3 EDK39285.2 - 3.7e-37 127.3 1.5 6e-37 126.7 1.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Atu4866 PF11512.3 EDK39285.2 - 0.12 12.0 0.0 3.6 7.4 0.0 2.6 2 1 1 3 3 3 0 Agrobacterium tumefaciens protein Atu4866 COPIIcoated_ERV PF07970.7 EDK39286.2 - 5.3e-74 248.5 0.0 6.7e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 EDK39286.2 - 2.6e-32 110.6 0.6 1.8e-31 107.9 0.1 2.1 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) WD40 PF00400.27 EDK39287.2 - 2.5e-15 55.6 4.5 2.1e-05 24.2 0.1 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 EDK39287.2 - 3.2e-05 22.3 1.1 0.0085 14.4 0.1 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain SdiA-regulated PF06977.6 EDK39287.2 - 0.0022 16.9 0.0 0.0053 15.7 0.0 1.6 2 0 0 2 2 2 1 SdiA-regulated eIF2A PF08662.6 EDK39287.2 - 0.0037 16.9 0.2 1.2 8.7 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Peptidase_S9_N PF02897.10 EDK39287.2 - 0.0039 15.8 0.1 0.051 12.1 0.0 2.5 3 0 0 3 3 3 1 Prolyl oligopeptidase, N-terminal beta-propeller domain BBS2_Mid PF14783.1 EDK39287.2 - 0.0044 16.7 0.1 0.018 14.7 0.0 2.1 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region zf-CCHC PF00098.18 EDK39288.2 - 4.6e-47 155.8 56.7 8.3e-08 31.8 1.7 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 EDK39288.2 - 3.4e-11 42.6 46.0 0.02 14.5 0.4 7.0 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.1 EDK39288.2 - 0.00095 18.8 51.2 0.4 10.4 0.9 7.0 2 2 5 7 7 7 5 Zinc knuckle zf-CCHC_6 PF15288.1 EDK39288.2 - 0.015 14.9 2.1 0.015 14.9 1.4 7.0 6 1 1 7 7 7 0 Zinc knuckle RRM_6 PF14259.1 EDK39289.2 - 2.6e-13 49.7 0.0 1.4e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 EDK39289.2 - 4e-11 43.3 0.0 6.8e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_5 PF13893.1 EDK39289.2 - 2.3e-10 40.1 0.0 3.9e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK39289.2 - 1.6e-08 34.0 0.0 6.8e-08 32.0 0.0 2.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.16 EDK39290.2 - 3.2e-08 33.3 15.4 9.8e-08 31.8 10.7 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EDK39290.2 - 0.017 14.9 13.5 0.017 14.9 9.4 2.7 3 1 1 4 4 4 0 Basic region leucine zipper Macoilin PF09726.4 EDK39290.2 - 0.018 13.3 14.8 0.024 12.9 10.2 1.1 1 0 0 1 1 1 0 Transmembrane protein LMSTEN PF07988.7 EDK39290.2 - 0.052 12.8 1.6 0.16 11.3 1.1 1.8 1 0 0 1 1 1 0 LMSTEN motif CAF-1_p150 PF11600.3 EDK39290.2 - 2.2 7.5 24.1 0.054 12.8 11.5 1.8 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal TPR_11 PF13414.1 EDK39291.2 - 1e-56 188.4 45.6 6.4e-17 60.9 1.8 6.2 4 2 3 7 7 7 7 TPR repeat TPR_1 PF00515.23 EDK39291.2 - 1.8e-50 166.5 33.3 2.7e-08 33.0 0.5 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 EDK39291.2 - 1e-40 134.3 32.8 3e-08 32.9 0.3 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 EDK39291.2 - 1.3e-25 89.4 14.9 1.2e-06 28.9 0.4 6.4 4 2 2 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.1 EDK39291.2 - 3.6e-24 84.4 22.0 3.6e-09 36.4 1.5 5.9 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 EDK39291.2 - 1e-22 78.1 31.7 1.6e-05 24.3 0.4 9.3 8 1 1 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.1 EDK39291.2 - 7.1e-22 75.9 13.6 0.0033 17.9 0.0 9.4 6 3 4 10 10 9 6 Tetratricopeptide repeat TPR_7 PF13176.1 EDK39291.2 - 4.3e-16 57.3 17.5 0.053 13.3 0.0 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.1 EDK39291.2 - 8.2e-16 58.1 22.2 1.5e-05 25.2 1.7 6.7 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 EDK39291.2 - 1.1e-13 50.1 20.0 0.17 12.1 0.0 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.1 EDK39291.2 - 1.2e-09 37.9 4.6 0.00027 20.7 0.0 6.0 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK39291.2 - 2.7e-08 33.7 29.0 0.9 10.1 0.0 8.9 9 0 0 9 9 8 3 Tetratricopeptide repeat Apc3 PF12895.2 EDK39291.2 - 1.6e-07 31.3 22.3 0.037 14.1 1.3 4.9 3 2 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 EDK39291.2 - 2.4e-06 27.3 8.5 0.00022 21.0 0.1 5.3 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 EDK39291.2 - 6.7e-05 22.6 8.1 0.82 9.6 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_21 PF09976.4 EDK39291.2 - 0.0002 21.2 22.2 0.088 12.7 0.1 5.3 4 1 0 5 5 5 3 Tetratricopeptide repeat Inhibitor_I9 PF05922.11 EDK39291.2 - 0.0016 19.0 0.0 0.018 15.5 0.0 2.8 2 0 0 2 2 2 1 Peptidase inhibitor I9 PPR_2 PF13041.1 EDK39291.2 - 0.042 13.8 0.4 65 3.6 0.0 4.3 5 0 0 5 5 5 0 PPR repeat family DUF3808 PF10300.4 EDK39291.2 - 0.12 10.9 5.8 0.04 12.4 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) DUF3856 PF12968.2 EDK39291.2 - 0.79 9.5 14.8 20 5.0 0.2 5.5 3 3 1 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_3 PF07720.7 EDK39291.2 - 1.8 8.4 26.0 0.72 9.7 0.4 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2225 PF09986.4 EDK39291.2 - 4.7 6.6 15.0 1.8 8.0 2.4 3.2 3 2 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Fungal_trans PF04082.13 EDK39292.2 - 2.1e-16 59.6 3.3 5e-16 58.3 2.3 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39292.2 - 3.1e-07 30.1 15.6 6.6e-07 29.1 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4510 PF14971.1 EDK39292.2 - 0.13 12.4 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) Zn_clus PF00172.13 EDK39293.2 - 1.6e-07 31.1 16.2 3.2e-07 30.1 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NARP1 PF12569.3 EDK39294.2 - 1.4e-133 446.4 28.2 9e-100 334.8 1.5 4.4 3 2 0 3 3 3 3 NMDA receptor-regulated protein 1 TPR_16 PF13432.1 EDK39294.2 - 5.9e-13 49.1 7.0 0.0016 19.0 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.12 EDK39294.2 - 4.9e-12 44.7 13.5 0.052 13.4 0.0 8.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 EDK39294.2 - 9.6e-11 41.8 9.7 0.0013 19.0 0.0 5.1 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EDK39294.2 - 1.8e-10 40.4 5.6 0.035 14.7 0.0 8.6 6 2 4 10 10 9 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK39294.2 - 2.3e-10 39.9 20.4 4.4e-06 26.2 0.2 6.1 6 1 1 7 7 7 3 TPR repeat TPR_17 PF13431.1 EDK39294.2 - 2.3e-08 33.5 2.6 0.16 12.2 0.0 5.5 4 1 0 4 4 3 3 Tetratricopeptide repeat Apc3 PF12895.2 EDK39294.2 - 3.2e-08 33.6 18.7 0.00078 19.5 0.4 5.8 5 1 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EDK39294.2 - 1.8e-05 24.5 13.6 0.056 13.3 0.1 6.0 6 1 1 7 7 6 2 Tetratricopeptide repeat BLVR PF06375.6 EDK39294.2 - 0.0002 21.2 2.6 0.00048 19.9 1.8 1.6 1 0 0 1 1 1 1 Bovine leukaemia virus receptor (BLVR) TPR_1 PF00515.23 EDK39294.2 - 0.00026 20.4 13.1 0.57 9.8 0.0 7.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_10 PF13374.1 EDK39294.2 - 0.0068 16.3 2.1 60 3.7 0.0 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat Rapsyn_N PF10579.4 EDK39294.2 - 0.0096 15.7 0.0 0.052 13.3 0.0 2.2 2 0 0 2 2 1 1 Rapsyn N-terminal myristoylation and linker region TPR_8 PF13181.1 EDK39294.2 - 0.019 14.7 20.6 0.051 13.3 0.0 7.5 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_9 PF13371.1 EDK39294.2 - 0.02 14.7 0.1 24 4.8 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF627 PF04781.7 EDK39294.2 - 0.054 13.1 0.3 0.054 13.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF627) RecQ5 PF06959.6 EDK39294.2 - 0.093 12.3 0.3 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 RecQ helicase protein-like 5 (RecQ5) Sel1 PF08238.7 EDK39294.2 - 0.23 12.1 2.5 0.53 10.9 0.2 3.0 4 0 0 4 4 1 0 Sel1 repeat Fis1_TPR_C PF14853.1 EDK39294.2 - 0.89 9.4 6.9 3.4 7.6 0.2 4.3 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Got1 PF04178.7 EDK39295.2 - 5.7e-32 110.2 17.8 7.6e-32 109.8 12.4 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family MFS_1_like PF12832.2 EDK39295.2 - 0.12 12.2 10.6 0.74 9.6 7.3 2.2 1 1 0 1 1 1 0 MFS_1 like family Imp-YgjV PF10688.4 EDK39295.2 - 0.22 10.9 11.2 0.29 10.5 7.8 1.1 1 0 0 1 1 1 0 Bacterial inner membrane protein ubiquitin PF00240.18 EDK39296.2 - 0.08 12.3 0.1 0.27 10.6 0.0 2.0 2 1 0 2 2 2 0 Ubiquitin family DUF2665 PF11654.3 EDK39297.1 - 4.1e-28 96.6 0.1 4.6e-28 96.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2665) RabGAP-TBC PF00566.13 EDK39298.2 - 6e-41 140.2 0.0 1e-40 139.4 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PalH PF08733.5 EDK39299.2 - 1.7e-110 369.1 9.6 2.1e-110 368.8 6.6 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF418 PF04235.7 EDK39299.2 - 0.044 13.4 0.2 0.044 13.4 0.1 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF418) DUF1746 PF08508.5 EDK39299.2 - 0.15 12.0 6.5 0.06 13.2 1.5 2.3 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1746) PseudoU_synth_2 PF00849.17 EDK39300.2 - 3.1e-32 111.6 0.1 4.9e-32 111.0 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.17 EDK39300.2 - 6.2e-19 67.5 0.4 1.1e-18 66.7 0.3 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF1556 PF07590.6 EDK39300.2 - 0.12 12.6 2.9 3.1 8.0 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1556) DUF3449 PF11931.3 EDK39301.2 - 6.9e-63 211.7 1.9 8.9e-63 211.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) zf-met PF12874.2 EDK39301.2 - 5.5e-13 48.6 8.3 3.3e-07 30.2 2.2 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EDK39301.2 - 3.8e-10 39.6 7.5 7.7e-09 35.4 1.9 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 EDK39301.2 - 1.9e-05 24.7 2.0 0.013 15.6 0.1 3.6 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.7 EDK39301.2 - 0.0069 15.9 3.3 0.0069 15.9 2.3 2.4 2 0 0 2 2 2 1 U1 zinc finger Zn_ribbon_2 PF12674.2 EDK39301.2 - 0.041 14.2 2.8 0.52 10.7 0.4 2.7 2 0 0 2 2 2 0 Putative zinc ribbon domain HD_assoc PF13286.1 EDK39301.2 - 0.055 13.7 1.2 0.19 12.0 0.0 2.4 3 0 0 3 3 3 0 Phosphohydrolase-associated domain zf-C2H2 PF00096.21 EDK39301.2 - 0.3 11.5 6.4 0.94 9.9 1.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF87 PF01935.12 EDK39301.2 - 2.1 8.1 6.2 0.42 10.4 1.2 2.0 2 1 0 2 2 2 0 Domain of unknown function DUF87 Exo_endo_phos PF03372.18 EDK39302.2 - 8.1e-12 45.5 0.0 1.1e-11 45.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AA_permease PF00324.16 EDK39303.2 - 1.7e-134 448.7 44.6 2.1e-134 448.4 30.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK39303.2 - 5.2e-39 133.9 48.9 7.1e-39 133.5 33.9 1.0 1 0 0 1 1 1 1 Amino acid permease PAP_central PF04928.12 EDK39304.2 - 2.9e-110 367.0 0.0 3.9e-110 366.6 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 EDK39304.2 - 2.8e-49 166.6 0.0 4.5e-49 165.9 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 EDK39304.2 - 3.5e-12 46.4 0.0 9.9e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Oxysterol_BP PF01237.13 EDK39305.2 - 3.5e-88 295.4 0.0 4.7e-88 295.0 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein PI3_PI4_kinase PF00454.22 EDK39306.2 - 2.4e-32 112.3 0.6 1.3e-31 109.8 0.1 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 EDK39306.2 - 4.4e-19 67.9 1.5 1.4e-18 66.3 1.0 2.0 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 EDK39306.2 - 2.5e-05 23.5 3.3 2.5e-05 23.5 2.3 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Sec10 PF07393.6 EDK39308.2 - 1.4e-73 248.3 18.5 1.7e-73 248.0 12.8 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.28 EDK39308.2 - 2.3e-07 30.3 0.0 1.2e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 EDK39308.2 - 0.0057 16.3 0.0 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like RsbRD_N PF14361.1 EDK39308.2 - 0.086 13.2 0.8 0.39 11.1 0.2 2.3 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain Imm16 PF15565.1 EDK39309.2 - 0.0031 17.3 0.3 0.046 13.5 0.1 2.5 1 1 0 2 2 2 1 Immunity protein 16 PPR_3 PF13812.1 EDK39309.2 - 0.0036 17.4 3.2 74 4.0 0.0 5.9 5 0 0 5 5 5 0 Pentatricopeptide repeat domain TPR_14 PF13428.1 EDK39309.2 - 0.006 17.1 0.1 8.4 7.3 0.0 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat PPR PF01535.15 EDK39309.2 - 0.061 13.3 0.2 5.8 7.1 0.0 4.0 5 0 0 5 5 5 0 PPR repeat Ribosomal_L31 PF01197.13 EDK39310.2 - 0.047 13.6 0.1 0.13 12.2 0.1 1.9 1 1 0 1 1 1 0 Ribosomal protein L31 Cpn60_TCP1 PF00118.19 EDK39311.2 - 8.9e-151 502.7 5.5 1e-150 502.5 3.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HSDR_N_2 PF13588.1 EDK39311.2 - 0.15 11.8 0.7 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Cyclin_N PF00134.18 EDK39312.2 - 4.1e-39 133.0 1.1 5.3e-38 129.4 0.2 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EDK39312.2 - 3.3e-09 36.7 0.1 8.8e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain CNTF PF01110.12 EDK39312.2 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Ciliary neurotrophic factor Myosin_head PF00063.16 EDK39313.2 - 1.4e-239 796.8 8.5 1.4e-239 796.8 5.9 3.6 3 2 0 4 4 4 1 Myosin head (motor domain) ATG16 PF08614.6 EDK39313.2 - 0.00082 19.2 23.2 0.00082 19.2 16.0 12.2 4 2 7 11 11 11 4 Autophagy protein 16 (ATG16) DUF2968 PF11180.3 EDK39313.2 - 0.0011 18.4 11.9 0.0011 18.4 8.2 10.6 4 2 8 12 12 12 2 Protein of unknown function (DUF2968) TPR_MLP1_2 PF07926.7 EDK39313.2 - 0.0043 16.8 2.6 0.0043 16.8 1.8 11.8 4 2 5 11 11 11 4 TPR/MLP1/MLP2-like protein Myosin_tail_1 PF01576.14 EDK39313.2 - 0.081 10.6 225.3 0.0041 14.9 14.4 5.9 2 2 2 5 5 5 0 Myosin tail Peptidase_M16_C PF05193.16 EDK39314.1 - 3.6e-37 127.8 0.0 1.2e-36 126.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EDK39314.1 - 1.3e-33 115.8 0.0 2.2e-32 111.8 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DMAP_binding PF06464.6 EDK39314.1 - 0.025 15.1 0.7 0.046 14.3 0.5 1.4 1 0 0 1 1 1 0 DMAP1-binding Domain Methyltransf_11 PF08241.7 EDK39315.2 - 0.00097 19.5 0.0 0.0021 18.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK39315.2 - 0.0011 19.3 0.3 0.019 15.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain BSP_II PF05432.6 EDK39315.2 - 0.0088 15.3 8.0 0.014 14.6 5.6 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Methyltransf_4 PF02390.12 EDK39315.2 - 0.09 11.8 0.3 0.17 10.8 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase RRN3 PF05327.6 EDK39315.2 - 2.4 6.1 6.2 3.6 5.5 4.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.4 EDK39315.2 - 3.5 6.2 9.2 4.9 5.7 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Prog_receptor PF02161.10 EDK39315.2 - 6.9 5.3 6.7 3.2 6.4 2.6 1.7 2 0 0 2 2 2 0 Progesterone receptor HLH PF00010.21 EDK39316.2 - 2.4e-18 65.5 0.0 4.7e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain p450 PF00067.17 EDK39317.1 - 5.5e-89 298.8 0.0 6.5e-89 298.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GHMP_kinases_N PF00288.21 EDK39318.2 - 3.5e-12 46.2 0.0 7.1e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EDK39318.2 - 0.021 14.9 0.0 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 GHMP kinases C terminal Bac_surface_Ag PF01103.18 EDK39319.2 - 2.5e-11 43.6 8.4 2.5e-11 43.6 5.8 1.5 2 0 0 2 2 2 1 Surface antigen RabGAP-TBC PF00566.13 EDK39320.2 - 2.3e-19 69.7 1.0 4.8e-19 68.6 0.7 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Elf1 PF05129.8 EDK39321.2 - 3.6e-30 103.4 2.0 4.8e-30 103.0 1.4 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.1 EDK39321.2 - 0.091 12.6 3.8 0.21 11.5 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger Prothymosin PF03247.9 EDK39321.2 - 0.094 12.8 5.4 0.14 12.3 3.7 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family Ribosomal_L37ae PF01780.14 EDK39321.2 - 0.12 12.2 0.4 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-C2H2_2 PF12756.2 EDK39321.2 - 0.45 10.6 3.7 5.1 7.2 0.4 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.5 EDK39321.2 - 0.88 9.5 3.2 8.5 6.4 2.3 2.3 1 1 1 2 2 2 0 Zinc ribbon domain GnHR_trans PF12369.3 EDK39321.2 - 1.1 9.7 5.4 18 5.8 1.2 2.2 2 0 0 2 2 2 0 Gonadotropin hormone receptor transmembrane region zf-AN1 PF01428.11 EDK39321.2 - 1.8 8.5 5.6 14 5.6 0.3 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger LRR_4 PF12799.2 EDK39322.2 - 5.1e-07 29.1 17.8 0.0027 17.2 2.1 6.3 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK39322.2 - 0.031 14.3 10.2 1.6 9.0 0.3 5.6 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.28 EDK39322.2 - 2 8.7 18.2 2.1 8.7 0.3 6.6 6 1 0 6 6 6 0 Leucine Rich Repeat MFS_1 PF07690.11 EDK39323.2 - 4.8e-13 48.5 3.2 9e-08 31.2 0.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4064 PF13273.1 EDK39323.2 - 1.5 8.9 9.1 0.77 9.8 0.5 3.9 2 1 0 3 3 3 0 Protein of unknown function (DUF4064) SRP54 PF00448.17 EDK39324.2 - 4.2e-78 261.3 2.2 1.2e-77 259.7 0.5 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 EDK39324.2 - 2.7e-23 82.1 6.4 2.7e-23 82.1 4.4 4.7 4 1 1 5 5 3 1 Signal peptide binding domain SRP54_N PF02881.14 EDK39324.2 - 1.1e-15 57.4 4.3 1.1e-15 57.4 3.0 2.1 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain cobW PF02492.14 EDK39324.2 - 3.4e-07 29.8 3.0 3.9e-05 23.1 0.2 3.2 3 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 EDK39324.2 - 5.6e-06 26.2 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain CbiA PF01656.18 EDK39324.2 - 2.3e-05 23.9 0.2 0.00012 21.4 0.1 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 EDK39324.2 - 4e-05 23.3 0.1 0.00013 21.6 0.1 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.1 EDK39324.2 - 0.00051 19.9 0.0 0.076 12.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain ArgK PF03308.11 EDK39324.2 - 0.0021 16.8 0.0 0.0021 16.8 0.0 3.1 3 1 1 4 4 4 1 ArgK protein AAA_17 PF13207.1 EDK39324.2 - 0.0036 18.1 0.1 0.012 16.4 0.0 1.9 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 EDK39324.2 - 0.012 15.2 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase SRPRB PF09439.5 EDK39324.2 - 0.019 14.2 4.9 3.8 6.6 0.0 3.9 4 0 0 4 4 4 0 Signal recognition particle receptor beta subunit MipZ PF09140.6 EDK39324.2 - 0.026 13.5 0.1 0.69 8.9 0.1 2.5 1 1 0 1 1 1 0 ATPase MipZ AAA_18 PF13238.1 EDK39324.2 - 0.031 14.5 0.2 0.32 11.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 EDK39324.2 - 0.038 14.1 0.8 0.19 11.8 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 EDK39324.2 - 0.25 10.7 2.1 3.2 7.0 0.2 2.6 1 1 1 2 2 2 0 AAA domain XPC-binding PF09280.6 EDK39324.2 - 1.7 8.1 22.8 1.6 8.2 0.2 3.4 2 1 1 3 3 3 0 XPC-binding domain AAA PF00004.24 EDK39324.2 - 1.9 8.6 5.2 3.4 7.8 0.5 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Peptidase_A22B PF04258.8 EDK39326.2 - 3e-54 184.5 8.5 1.1e-53 182.6 5.9 1.9 1 1 0 1 1 1 1 Signal peptide peptidase DUF1119 PF06550.6 EDK39326.2 - 9.2e-07 28.2 3.5 9.2e-07 28.2 2.4 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1119) KH_1 PF00013.24 EDK39328.2 - 2.1e-36 123.3 0.4 2e-13 49.7 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 EDK39328.2 - 4.5e-22 77.2 12.8 1.9e-07 30.5 2.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 EDK39328.2 - 3.2e-09 36.2 1.7 0.00026 20.5 0.0 3.7 4 0 0 4 4 4 3 KH domain KH_2 PF07650.12 EDK39328.2 - 6.1e-08 32.1 7.1 0.05 13.1 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 EDK39328.2 - 2.1e-07 30.6 0.7 0.95 9.3 0.0 3.4 3 0 0 3 3 3 3 NusA-like KH domain GAF_2 PF13185.1 EDK39329.1 - 4e-10 40.3 0.0 6.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 EDK39329.1 - 0.00035 20.7 0.0 0.00049 20.2 0.0 1.3 1 1 0 1 1 1 1 GAF domain GAF_3 PF13492.1 EDK39329.1 - 0.0018 18.3 0.0 0.0037 17.3 0.0 1.7 1 1 0 1 1 1 1 GAF domain CRT10 PF08728.5 EDK39330.2 - 2e-194 647.5 1.3 8.1e-133 443.9 0.1 2.5 2 1 1 3 3 3 2 CRT10 CENP-C_C PF11699.3 EDK39331.2 - 6.6e-24 83.7 0.2 1.3e-23 82.8 0.1 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.1 EDK39331.2 - 8.2e-17 62.0 6.3 8.2e-17 62.0 4.3 3.2 2 1 1 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.6 EDK39331.2 - 4.2e-06 26.1 0.1 7.8e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.13 EDK39331.2 - 0.025 14.1 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase V-SNARE_C PF12352.3 EDK39331.2 - 0.054 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus YflT PF11181.3 EDK39331.2 - 0.059 13.5 0.3 0.13 12.4 0.2 1.5 1 0 0 1 1 1 0 Heat induced stress protein YflT Ribosomal_L10 PF00466.15 EDK39332.2 - 1.2e-14 54.0 0.0 3.7e-14 52.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 ARL2_Bind_BART PF11527.3 EDK39333.2 - 0.052 13.3 1.8 1.4 8.7 0.2 3.1 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART Complex1_LYR PF05347.10 EDK39334.1 - 1.4e-07 31.2 0.8 2.3e-07 30.5 0.6 1.4 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EDK39334.1 - 2.9e-07 30.6 1.2 3.8e-07 30.2 0.8 1.2 1 0 0 1 1 1 1 Complex1_LYR-like DUF4080 PF13311.1 EDK39334.1 - 0.035 14.1 0.1 0.041 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) CH PF00307.26 EDK39335.2 - 4.8e-72 238.9 0.2 8.6e-22 77.2 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.3 EDK39335.2 - 3.5e-10 39.4 0.0 0.066 12.8 0.0 4.3 4 0 0 4 4 4 4 CAMSAP CH domain EF-hand_1 PF00036.27 EDK39335.2 - 0.00012 21.0 0.0 0.0044 16.2 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 EDK39335.2 - 0.041 14.0 0.3 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair Pep3_Vps18 PF05131.9 EDK39336.2 - 7.6e-25 87.0 0.1 2.2e-24 85.5 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Vps39_2 PF10367.4 EDK39336.2 - 1.8e-05 24.8 0.8 5.9e-05 23.2 0.6 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.1 EDK39336.2 - 0.00034 20.3 3.4 0.00077 19.2 2.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK39336.2 - 0.0013 18.6 3.3 0.0035 17.3 2.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 EDK39336.2 - 0.013 15.4 2.8 0.028 14.4 1.9 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.20 EDK39336.2 - 0.03 13.9 3.7 0.08 12.6 2.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK39336.2 - 0.078 13.1 4.2 0.029 14.4 0.8 1.8 2 0 0 2 2 1 0 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 EDK39336.2 - 0.18 11.4 5.3 0.49 10.1 3.7 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 EDK39336.2 - 0.18 11.4 2.8 0.5 10.0 1.9 1.7 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 EDK39336.2 - 0.91 9.3 3.7 0.53 10.0 1.1 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_5 PF14634.1 EDK39336.2 - 1.6 8.5 6.6 0.59 9.9 2.7 1.7 2 0 0 2 2 2 0 zinc-RING finger domain Spb1_C PF07780.7 EDK39337.2 - 1.1e-73 247.3 23.7 1.1e-73 247.3 16.4 3.3 3 0 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.3 EDK39337.2 - 1.5e-53 180.5 14.0 1.5e-53 180.5 9.7 4.6 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 EDK39337.2 - 2.8e-51 174.0 0.1 7.7e-51 172.6 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Latarcin PF10279.4 EDK39337.2 - 0.0021 18.2 6.2 0.15 12.2 2.7 3.6 2 1 0 2 2 2 1 Latarcin precursor ATP_transf PF09830.4 EDK39339.1 - 1.9e-20 72.3 0.0 3.2e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 EDK39339.1 - 0.00027 21.4 0.0 0.001 19.5 0.0 2.0 2 0 0 2 2 2 1 HIT domain UCR_14kD PF02271.11 EDK39340.2 - 1.5e-42 143.6 0.1 1.7e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.22 EDK39341.2 - 4e-57 189.9 1.3 6.9e-19 67.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sugar_tr PF00083.19 EDK39342.2 - 7.7e-34 117.0 31.6 3.2e-33 114.9 21.9 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39342.2 - 9.3e-32 110.0 32.7 9.3e-32 110.0 22.7 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39343.2 - 2.7e-35 121.8 23.1 7.3e-35 120.4 16.0 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39343.2 - 1.1e-34 119.7 24.8 1.1e-34 119.7 17.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Histone PF00125.19 EDK39344.1 - 5.7e-23 80.8 0.4 8.5e-23 80.2 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK39344.1 - 1.6e-07 31.2 0.8 3.6e-07 30.1 0.1 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 EDK39344.1 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.8 EDK39344.1 - 0.038 13.4 0.2 0.07 12.5 0.2 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain Herpes_glycop_H PF02489.11 EDK39344.1 - 0.04 11.9 0.9 0.04 11.9 0.7 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein H ImcF-related_N PF14331.1 EDK39344.1 - 0.092 11.6 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 ImcF-related N-terminal domain tRNA_synt_1c_R2 PF04557.10 EDK39344.1 - 2.7 8.7 6.7 2.5 8.8 3.6 1.7 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Histone PF00125.19 EDK39345.1 - 4.3e-26 90.8 0.0 5.4e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK39345.1 - 5.3e-05 23.2 0.0 7.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Acid_PPase PF12689.2 EDK39346.2 - 6.8e-53 178.7 0.0 8.1e-53 178.5 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase Memo PF01875.12 EDK39346.2 - 0.063 12.1 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 Memo-like protein NIF PF03031.13 EDK39346.2 - 0.074 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase ZZ PF00569.12 EDK39347.2 - 8.7e-10 37.9 2.7 1.9e-09 36.8 1.9 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF3361 PF11841.3 EDK39349.2 - 0.03 14.0 1.3 0.035 13.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) Snapin_Pallidin PF14712.1 EDK39349.2 - 0.069 13.4 0.7 0.27 11.5 0.2 2.2 1 1 1 2 2 2 0 Snapin/Pallidin DUF1691 PF07950.6 EDK39349.2 - 0.075 12.9 0.2 0.2 11.5 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1691) DRIM PF07539.7 EDK39350.2 - 7.4e-45 151.8 2.0 3.7e-43 146.3 0.3 3.6 3 0 0 3 3 3 2 Down-regulated in metastasis Ku_PK_bind PF08785.6 EDK39350.2 - 0.11 12.3 4.1 2.5 8.0 0.1 4.6 3 0 0 3 3 3 0 Ku C terminal domain like DUF155 PF02582.9 EDK39351.2 - 7.6e-60 201.7 1.9 2.5e-59 200.1 1.6 1.6 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 DUF4552 PF15089.1 EDK39351.2 - 0.0059 15.5 0.1 0.0093 14.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4552) MalM PF07148.7 EDK39351.2 - 0.023 14.1 0.3 0.047 13.1 0.1 1.6 2 0 0 2 2 2 0 Maltose operon periplasmic protein precursor (MalM) UPF0449 PF15136.1 EDK39351.2 - 0.039 14.1 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 STE PF02200.11 EDK39352.2 - 0.024 14.7 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 STE like transcription factor AIM24 PF01987.12 EDK39353.2 - 6.1e-07 29.1 0.2 2.2e-06 27.2 0.1 2.0 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 PIP5K PF01504.13 EDK39354.2 - 5.6e-85 284.4 0.2 1.1e-84 283.4 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3836 PF12930.2 EDK39354.2 - 0.11 12.0 0.1 0.11 12.0 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF3836) Suc_Fer-like PF06999.7 EDK39355.2 - 1.1e-51 176.0 0.1 1.3e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Thioredoxin PF00085.15 EDK39356.2 - 1.1e-32 111.7 0.0 2.1e-22 78.7 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 EDK39356.2 - 1.4e-11 44.5 0.3 1.5e-05 25.1 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EDK39356.2 - 2.1e-11 43.7 0.7 2.1e-07 30.9 0.1 3.1 3 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.1 EDK39356.2 - 2.6e-09 36.9 0.1 1.2e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.16 EDK39356.2 - 0.0011 18.6 1.3 0.029 14.0 0.1 3.0 3 2 2 5 5 5 1 AhpC/TSA family ERp29_N PF07912.8 EDK39356.2 - 0.0024 17.8 0.9 0.0085 16.0 0.3 2.2 2 1 0 2 2 2 1 ERp29, N-terminal domain Glutaredoxin PF00462.19 EDK39356.2 - 0.0032 17.4 0.0 0.15 12.0 0.0 2.7 2 0 0 2 2 2 1 Glutaredoxin TraF PF13728.1 EDK39356.2 - 0.012 15.1 0.1 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.1 EDK39356.2 - 0.072 12.9 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin domain Vps39_2 PF10367.4 EDK39356.2 - 0.12 12.5 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DUF836 PF05768.9 EDK39357.1 - 3.5e-13 49.6 0.3 4.6e-13 49.2 0.2 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 EDK39357.1 - 0.00037 20.4 0.3 0.00088 19.2 0.2 1.7 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.1 EDK39357.1 - 0.14 12.3 0.4 0.17 12.0 0.3 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain adh_short PF00106.20 EDK39358.1 - 3.9e-07 30.1 0.0 6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK39358.1 - 0.00055 19.7 0.0 0.00067 19.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 EDK39358.1 - 0.0049 16.0 0.0 0.0058 15.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.20 EDK39359.2 - 2.7e-21 76.2 0.0 3.6e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK39359.2 - 2.9e-09 37.0 0.0 3.8e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 EDK39359.2 - 0.00013 21.6 0.1 0.00026 20.6 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 EDK39359.2 - 0.0002 21.4 0.0 0.00036 20.6 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EDK39359.2 - 0.00055 19.6 0.0 0.0014 18.2 0.0 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK39359.2 - 0.011 15.1 0.0 0.019 14.3 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.17 EDK39360.2 - 5.1e-23 81.8 0.0 8.1e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 EDK39360.2 - 6.1e-15 55.0 0.0 2.2e-14 53.2 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.19 EDK39360.2 - 0.0031 17.8 0.0 0.0055 17.0 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 EDK39360.2 - 0.056 13.3 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF676 PF05057.9 EDK39361.2 - 1.1e-36 126.2 0.0 2.2e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.11 EDK39361.2 - 0.055 12.9 0.1 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.20 EDK39361.2 - 0.071 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.2 EDK39361.2 - 0.089 12.5 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Transket_pyr PF02779.19 EDK39362.2 - 4.2e-66 221.8 0.0 6.9e-66 221.1 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 EDK39362.2 - 2.9e-54 183.8 0.0 4.2e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Aminotran_1_2 PF00155.16 EDK39363.2 - 2.3e-38 132.0 0.0 3.1e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II LRR_4 PF12799.2 EDK39364.2 - 7.5e-05 22.2 13.3 0.033 13.8 0.2 4.7 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) PQQ PF01011.16 EDK39364.2 - 0.047 13.2 0.0 0.92 9.1 0.0 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat IMPDH PF00478.20 EDK39364.2 - 0.069 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain LRR_1 PF00560.28 EDK39364.2 - 0.2 11.8 14.8 48 4.5 0.1 6.6 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.1 EDK39364.2 - 0.55 10.0 17.8 0.66 9.7 0.7 5.3 2 1 2 5 5 5 0 Leucine rich repeat LRR_7 PF13504.1 EDK39364.2 - 1.9 9.0 14.6 13 6.4 0.2 6.2 6 0 0 6 6 6 0 Leucine rich repeat Sod_Cu PF00080.15 EDK39365.2 - 3.6e-21 75.7 0.0 5.8e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) APH PF01636.18 EDK39366.2 - 2.1e-35 122.6 0.0 2.8e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 EDK39366.2 - 3.9e-08 32.7 0.0 5.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 EDK39366.2 - 7.5e-06 25.6 0.0 1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 EDK39366.2 - 0.00028 19.6 0.0 0.0004 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.9 EDK39366.2 - 0.0042 16.0 0.0 0.027 13.4 0.0 2.1 1 1 0 1 1 1 1 Fructosamine kinase APH_6_hur PF04655.9 EDK39366.2 - 0.0068 15.5 0.0 0.0089 15.2 0.0 1.4 1 1 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase Mss4 PF04421.8 EDK39368.2 - 2e-09 37.1 0.2 1.4e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Mss4 protein GMC_oxred_N PF00732.14 EDK39369.2 - 1.6e-61 208.1 0.1 2.2e-61 207.6 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 EDK39369.2 - 9.8e-22 77.7 0.1 5.8e-21 75.3 0.0 2.2 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.19 EDK39369.2 - 1.7e-06 27.1 0.1 4.5e-06 25.7 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EDK39369.2 - 0.0023 16.8 0.0 0.53 9.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EDK39369.2 - 0.019 14.9 0.2 0.057 13.4 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HVSL PF09749.4 EDK39370.2 - 4.1e-07 29.2 1.0 0.00083 18.4 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised conserved protein ArfGap PF01412.13 EDK39371.2 - 3.1e-31 107.5 0.0 3.1e-31 107.5 0.0 2.5 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf UBA PF00627.26 EDK39371.2 - 0.0079 16.0 0.0 0.077 12.8 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain Med15 PF09606.5 EDK39371.2 - 0.16 10.1 64.0 0.22 9.6 44.4 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3332 PF11810.3 EDK39371.2 - 0.67 9.6 11.6 1.2 8.8 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) ABC2_membrane_3 PF12698.2 EDK39371.2 - 8.1 5.3 13.6 12 4.8 9.4 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_2 PF07724.9 EDK39372.2 - 2.3e-47 161.0 0.2 9.7e-45 152.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 EDK39372.2 - 5.8e-23 81.5 0.1 1.1e-12 48.2 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 EDK39372.2 - 1.1e-22 79.6 0.6 3.9e-22 77.9 0.4 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 EDK39372.2 - 7.3e-15 54.9 0.0 2.8e-09 36.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.15 EDK39372.2 - 2.2e-13 49.9 0.6 3.2e-10 39.7 0.1 3.4 3 0 0 3 3 3 1 Clp amino terminal domain AAA_16 PF13191.1 EDK39372.2 - 8.1e-12 45.4 10.9 1.4e-05 25.1 0.2 5.2 3 3 1 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.21 EDK39372.2 - 1.1e-11 44.5 0.5 1.4e-06 27.9 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 EDK39372.2 - 1.8e-09 37.8 0.0 0.00087 19.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EDK39372.2 - 9.8e-06 25.4 7.9 0.0022 17.7 1.2 4.8 5 1 0 5 5 4 1 Archaeal ATPase Mg_chelatase PF01078.16 EDK39372.2 - 2.2e-05 23.7 0.1 0.8 8.8 0.0 3.4 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI NACHT PF05729.7 EDK39372.2 - 0.00014 21.5 0.1 0.045 13.4 0.0 2.7 2 0 0 2 2 2 1 NACHT domain DUF258 PF03193.11 EDK39372.2 - 0.0016 17.6 0.0 0.085 12.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_33 PF13671.1 EDK39372.2 - 0.0019 18.0 0.7 0.15 11.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 EDK39372.2 - 0.002 17.5 0.0 0.32 10.3 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 EDK39372.2 - 0.0023 17.0 0.0 0.094 11.8 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_3 PF07726.6 EDK39372.2 - 0.0057 16.2 0.0 0.15 11.6 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 EDK39372.2 - 0.0076 15.9 0.0 2.8 7.6 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 EDK39372.2 - 0.0077 15.7 0.0 0.42 10.0 0.0 2.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_18 PF13238.1 EDK39372.2 - 0.0077 16.5 6.4 1 9.6 0.0 4.3 3 1 1 4 4 4 1 AAA domain AAA_30 PF13604.1 EDK39372.2 - 0.0084 15.7 0.7 1.7 8.2 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.1 EDK39372.2 - 0.01 15.3 0.2 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_17 PF13207.1 EDK39372.2 - 0.013 16.3 12.3 0.083 13.7 0.0 4.5 4 1 0 4 4 2 0 AAA domain AAA_24 PF13479.1 EDK39372.2 - 0.019 14.5 0.0 5.7 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Torsin PF06309.6 EDK39372.2 - 0.025 14.4 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Torsin ABC_tran PF00005.22 EDK39372.2 - 0.025 14.8 1.4 4.3 7.6 0.0 3.1 3 0 0 3 3 2 0 ABC transporter APS_kinase PF01583.15 EDK39372.2 - 0.038 13.6 0.5 0.19 11.3 0.0 2.4 2 1 1 3 3 2 0 Adenylylsulphate kinase DUF3945 PF13101.1 EDK39372.2 - 0.048 12.9 0.0 0.21 10.8 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) UPF0079 PF02367.12 EDK39372.2 - 0.06 12.9 0.0 4.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Miro PF08477.8 EDK39372.2 - 0.076 13.5 0.1 1.3 9.5 0.0 3.0 3 0 0 3 3 2 0 Miro-like protein PEPCK_ATP PF01293.15 EDK39372.2 - 0.11 11.0 0.0 0.35 9.3 0.0 1.7 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase RNA_helicase PF00910.17 EDK39372.2 - 0.11 12.7 0.0 23 5.2 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_10 PF12846.2 EDK39372.2 - 0.91 8.8 11.3 1.3 8.3 0.1 4.2 3 2 0 4 4 4 0 AAA-like domain eIF-6 PF01912.13 EDK39373.1 - 2.2e-85 284.7 1.0 2.8e-85 284.4 0.7 1.1 1 0 0 1 1 1 1 eIF-6 family Phage_holin_6 PF10746.4 EDK39373.1 - 0.022 14.4 0.1 0.063 13.0 0.0 1.7 2 0 0 2 2 2 0 Phage holin family 6 PI3_PI4_kinase PF00454.22 EDK39374.2 - 5.9e-37 127.3 0.0 2e-36 125.6 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 EDK39374.2 - 5.8e-24 84.2 0.2 3e-23 81.9 0.0 2.2 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) TRP PF06011.7 EDK39375.2 - 2.6e-160 533.7 31.6 3.5e-160 533.3 21.9 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 EDK39375.2 - 4.1e-47 159.7 0.2 1.1e-46 158.4 0.2 1.7 1 0 0 1 1 1 1 ML-like domain Neur_chan_memb PF02932.11 EDK39375.2 - 0.005 16.7 0.9 0.027 14.3 0.0 2.4 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF2231 PF09990.4 EDK39375.2 - 2.1 8.7 15.6 0.23 11.8 0.4 3.7 3 1 0 3 3 3 0 Predicted membrane protein (DUF2231) TBPIP PF07106.8 EDK39376.2 - 0.13 11.8 1.1 0.19 11.2 0.7 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF2521 PF10730.4 EDK39376.2 - 0.14 11.9 0.1 5 6.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2521) DUF883 PF05957.8 EDK39376.2 - 0.17 12.3 1.4 0.29 11.5 0.6 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MARVEL PF01284.18 EDK39377.2 - 1.5e-05 24.8 12.8 2.4e-05 24.2 8.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain H_PPase PF03030.11 EDK39377.2 - 0.57 8.3 6.6 0.87 7.7 4.6 1.2 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase 2-oxoacid_dh PF00198.18 EDK39378.1 - 1.3e-80 269.9 0.1 1.9e-80 269.4 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 EDK39378.1 - 1.1e-20 73.0 3.6 2e-20 72.1 2.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 EDK39378.1 - 2e-07 30.5 0.9 0.0003 20.4 0.3 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.14 EDK39378.1 - 1.6e-05 24.5 1.1 4.1e-05 23.2 0.8 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.1 EDK39378.1 - 0.00013 21.6 0.7 0.0027 17.4 0.1 2.7 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.1 EDK39378.1 - 0.00043 20.5 0.8 0.032 14.5 0.1 2.5 1 1 1 2 2 2 1 HlyD family secretion protein HlyD PF00529.15 EDK39378.1 - 0.0076 15.5 0.1 0.026 13.8 0.0 1.8 2 0 0 2 2 2 1 HlyD family secretion protein CDC45 PF02724.9 EDK39378.1 - 0.16 9.9 6.4 0.2 9.6 4.5 1.3 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.7 EDK39378.1 - 0.29 10.9 17.1 0.41 10.4 11.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.5 EDK39378.1 - 0.33 10.9 19.2 0.64 10.0 13.3 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GAGA_bind PF06217.7 EDK39378.1 - 0.41 10.5 9.3 0.61 10.0 6.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family MIP-T3 PF10243.4 EDK39378.1 - 0.7 8.2 28.6 0.97 7.8 19.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ndc1_Nup PF09531.5 EDK39378.1 - 2.2 6.5 4.0 2.8 6.2 2.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1510 PF07423.6 EDK39378.1 - 7.6 5.8 21.3 1.8 7.8 12.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) zf-C2H2 PF00096.21 EDK39379.2 - 5.7e-10 38.9 26.4 5.9e-05 23.1 1.5 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39379.2 - 8.3e-10 38.3 21.5 0.0012 19.0 0.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK39379.2 - 8.9e-06 25.7 24.1 6.1e-05 23.1 0.3 4.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EDK39379.2 - 0.12 12.5 8.0 1.6 8.9 0.2 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.13 EDK39379.2 - 0.28 11.6 11.8 0.032 14.5 2.1 2.4 1 1 1 2 2 2 0 TRAF-type zinc finger zf-BED PF02892.10 EDK39379.2 - 0.87 9.3 7.1 13 5.6 2.4 3.1 2 1 1 3 3 3 0 BED zinc finger zf-C2H2 PF00096.21 EDK39380.2 - 9.4e-11 41.4 16.0 3.2e-05 23.9 1.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39380.2 - 1.1e-08 34.7 13.7 0.00047 20.2 3.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK39380.2 - 2.1e-08 34.0 15.5 3e-06 27.2 4.3 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 EDK39380.2 - 7.6e-06 25.9 9.6 0.0024 17.9 1.5 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK39380.2 - 6e-05 23.0 9.6 0.0037 17.4 1.4 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-Di19 PF05605.7 EDK39380.2 - 0.0016 18.5 4.3 0.0026 17.8 3.0 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 EDK39380.2 - 0.0033 17.1 10.7 0.061 13.0 3.2 2.5 1 1 1 2 2 2 2 BED zinc finger zf-CHCC PF10276.4 EDK39380.2 - 0.19 11.6 0.1 0.19 11.6 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_2 PF12756.2 EDK39380.2 - 0.27 11.3 7.4 3.8 7.6 0.5 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 EDK39380.2 - 0.46 10.4 6.9 2 8.4 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger PyrI_C PF02748.10 EDK39380.2 - 2.5 7.6 4.8 4.6 6.7 0.3 2.4 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.1 EDK39380.2 - 4.9 6.9 9.8 6.4 6.5 2.0 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Kelch_6 PF13964.1 EDK39381.2 - 5e-05 23.2 0.4 0.0023 18.0 0.0 2.9 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 EDK39381.2 - 0.0015 18.6 0.0 0.041 14.0 0.0 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Chorismate_synt PF01264.16 EDK39382.2 - 3.8e-133 443.2 0.0 4.3e-133 443.0 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SRPRB PF09439.5 EDK39383.2 - 3.2e-30 104.6 0.0 3.9e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 EDK39383.2 - 5.8e-09 35.4 0.0 1.3e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK39383.2 - 1.9e-06 27.2 0.0 2.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 EDK39383.2 - 3.4e-06 26.9 0.1 5.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 EDK39383.2 - 4.9e-06 26.2 0.2 0.00065 19.3 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 EDK39383.2 - 1.1e-05 24.9 0.0 0.0001 21.7 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 EDK39383.2 - 0.0006 20.3 0.0 0.001 19.5 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 EDK39383.2 - 0.0026 17.1 0.0 0.0047 16.3 0.0 1.4 1 1 0 1 1 1 1 Ras family AAA_22 PF13401.1 EDK39383.2 - 0.0033 17.5 0.0 0.0064 16.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK39383.2 - 0.022 14.7 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 EDK39383.2 - 0.024 14.0 0.1 0.027 13.9 0.1 1.5 1 1 0 1 1 1 0 AAA-like domain Septin PF00735.13 EDK39383.2 - 0.042 12.8 0.0 0.37 9.7 0.0 2.1 2 0 0 2 2 2 0 Septin Dynamin_N PF00350.18 EDK39383.2 - 0.052 13.3 0.1 9.1 6.0 0.1 2.4 1 1 1 2 2 2 0 Dynamin family Flp_Fap PF04964.9 EDK39383.2 - 0.054 13.0 2.5 0.13 11.8 1.1 2.0 2 0 0 2 2 2 0 Flp/Fap pilin component AAA_23 PF13476.1 EDK39383.2 - 0.079 13.2 0.8 0.73 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EDK39383.2 - 0.099 11.8 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 EDK39383.2 - 0.12 12.6 0.2 0.27 11.5 0.1 1.9 1 1 0 1 1 1 0 ABC transporter Vfa1 PF08432.5 EDK39384.2 - 5.2e-49 166.7 6.4 6.5e-49 166.4 4.4 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Mnd1 PF03962.10 EDK39384.2 - 0.0019 17.9 1.6 0.0026 17.4 1.1 1.1 1 0 0 1 1 1 1 Mnd1 family LXG PF04740.7 EDK39384.2 - 0.038 13.7 1.0 0.053 13.3 0.7 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily LRS4 PF10422.4 EDK39384.2 - 0.039 13.3 1.9 0.051 12.9 1.3 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Glyco_transf_36 PF06165.6 EDK39384.2 - 0.044 13.6 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 36 Cep57_CLD_2 PF14197.1 EDK39384.2 - 0.054 13.4 1.2 2.3 8.2 0.1 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 HalX PF08663.5 EDK39384.2 - 0.08 12.9 1.0 14 5.7 0.2 2.5 3 0 0 3 3 3 0 HalX domain DUF342 PF03961.8 EDK39384.2 - 0.095 11.0 2.8 0.12 10.7 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GreA_GreB_N PF03449.10 EDK39384.2 - 0.2 11.7 1.3 2.4 8.2 0.1 2.2 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal DUF2046 PF09755.4 EDK39384.2 - 0.22 10.3 3.8 0.56 9.0 2.5 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Cortex-I_coil PF09304.5 EDK39384.2 - 0.22 11.5 6.4 2.2 8.3 4.4 2.1 1 1 0 1 1 1 0 Cortexillin I, coiled coil HR1 PF02185.11 EDK39384.2 - 0.26 11.0 3.5 2.5 7.9 0.3 2.5 2 0 0 2 2 2 0 Hr1 repeat BBS2_C PF14782.1 EDK39384.2 - 0.32 9.5 8.1 0.039 12.5 2.1 1.8 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal DUF3450 PF11932.3 EDK39384.2 - 0.52 9.5 4.6 0.48 9.6 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Prefoldin_2 PF01920.15 EDK39384.2 - 0.82 9.4 7.9 9.9 5.9 0.0 2.5 2 1 0 2 2 2 0 Prefoldin subunit DUF2681 PF10883.3 EDK39384.2 - 1.2 9.3 4.9 0.39 10.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Syntaxin PF00804.20 EDK39384.2 - 1.7 8.8 4.7 9.6 6.4 3.4 1.9 1 1 1 2 2 2 0 Syntaxin TMF_DNA_bd PF12329.3 EDK39384.2 - 2.7 7.8 10.5 0.65 9.8 1.4 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.16 EDK39384.2 - 7.2 6.6 11.7 4.5 7.2 0.1 3.2 2 1 0 3 3 3 0 bZIP transcription factor Ax_dynein_light PF10211.4 EDK39384.2 - 7.8 6.2 7.7 3.9 7.2 3.0 1.9 1 1 1 2 2 2 0 Axonemal dynein light chain Tropomyosin_1 PF12718.2 EDK39384.2 - 8.3 6.2 11.6 2.4e+02 1.5 8.1 2.1 1 1 0 1 1 1 0 Tropomyosin like Metallophos PF00149.23 EDK39385.1 - 1.4e-44 151.8 0.2 1.8e-44 151.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_S27e PF01667.12 EDK39386.1 - 2e-26 91.2 6.2 2.2e-26 91.1 4.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 EDK39386.1 - 0.0094 15.8 3.9 0.0098 15.7 2.7 1.2 1 0 0 1 1 1 1 IBR domain zinc_ribbon_4 PF13717.1 EDK39386.1 - 0.16 11.7 3.6 6.6 6.5 2.5 2.4 1 1 0 1 1 1 0 zinc-ribbon domain DUF4206 PF13901.1 EDK39386.1 - 0.26 10.7 2.2 0.25 10.8 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) DUF3133 PF11331.3 EDK39386.1 - 0.27 10.8 5.0 0.39 10.3 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3133) zinc_ribbon_5 PF13719.1 EDK39386.1 - 0.29 10.7 4.2 1.3 8.6 0.2 2.4 1 1 1 2 2 2 0 zinc-ribbon domain TRA-1_regulated PF02343.11 EDK39386.1 - 0.82 9.1 3.7 0.84 9.1 2.6 1.1 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 zf-CXXC PF02008.15 EDK39386.1 - 2.9 7.7 6.1 40 4.1 4.2 2.0 1 1 0 1 1 1 0 CXXC zinc finger domain ZZ PF00569.12 EDK39386.1 - 3.3 7.3 6.5 8.2 6.0 1.0 2.6 1 1 1 2 2 2 0 Zinc finger, ZZ type TFIIS_C PF01096.13 EDK39386.1 - 6.2 6.5 6.2 63 3.3 3.4 2.2 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) Aminotran_1_2 PF00155.16 EDK39387.1 - 2.3e-76 257.1 0.0 2.6e-76 256.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Abhydrolase_6 PF12697.2 EDK39387.1 - 0.11 12.3 0.0 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family RTA1 PF04479.8 EDK39388.2 - 2.7e-23 82.6 4.6 3.5e-23 82.2 3.2 1.1 1 0 0 1 1 1 1 RTA1 like protein CTV_P6 PF06706.6 EDK39388.2 - 0.049 13.1 0.1 0.049 13.1 0.1 2.4 3 0 0 3 3 3 0 Citrus tristeza virus 6-kDa protein DUF1240 PF06836.7 EDK39388.2 - 0.062 13.5 1.1 7.6 6.8 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1240) DUF1129 PF06570.6 EDK39388.2 - 2 7.6 5.6 3.2 7.0 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) RTA1 PF04479.8 EDK39389.2 - 5.3e-32 111.1 1.4 6.6e-32 110.8 1.0 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF4084 PF13321.1 EDK39389.2 - 0.019 14.2 1.2 0.024 13.9 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4084) PMP1_2 PF08114.6 EDK39389.2 - 0.075 12.5 0.2 1.2 8.6 0.0 2.6 2 0 0 2 2 2 0 ATPase proteolipid family AIF-MLS PF14962.1 EDK39389.2 - 0.2 11.3 1.0 0.4 10.3 0.1 1.8 2 0 0 2 2 2 0 Mitochondria Localisation Sequence EMP24_GP25L PF01105.19 EDK39390.2 - 1.1e-45 155.6 0.8 1.2e-45 155.4 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3753 PF12575.3 EDK39390.2 - 0.092 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Pkinase PF00069.20 EDK39391.2 - 2e-76 256.5 0.0 2.5e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39391.2 - 1.6e-34 119.1 0.1 2.9e-34 118.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EDK39391.2 - 0.00027 20.0 0.2 0.00044 19.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EDK39391.2 - 0.0047 15.9 0.0 0.012 14.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 EDK39391.2 - 0.0062 16.2 0.5 0.057 13.1 0.1 1.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EDK39391.2 - 0.031 13.1 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2406 PF10295.4 EDK39392.1 - 3.6e-25 88.2 1.0 3.6e-25 88.2 0.7 1.7 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) TPR_11 PF13414.1 EDK39393.2 - 9.1e-09 34.8 1.0 5.7e-08 32.2 0.2 2.3 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 EDK39393.2 - 2.8e-05 23.6 0.1 0.058 13.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK39393.2 - 8.2e-05 22.4 0.3 0.0046 16.8 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 EDK39393.2 - 0.00039 19.8 1.0 0.046 13.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK39393.2 - 0.00085 18.9 0.8 2.3 8.2 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_like PF09279.6 EDK39393.2 - 0.022 14.7 0.2 0.099 12.6 0.1 2.1 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like Apc3 PF12895.2 EDK39393.2 - 0.034 14.2 2.1 0.053 13.6 0.3 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.2 EDK39393.2 - 0.045 13.5 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_19 PF14559.1 EDK39393.2 - 0.046 14.0 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.5 EDK39393.2 - 3.8 6.0 6.1 1.9 7.0 0.1 2.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) Nop10p PF04135.7 EDK39394.1 - 5.6e-22 77.2 0.2 7e-22 76.9 0.1 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family RRM_1 PF00076.17 EDK39395.2 - 1.2e-18 66.5 0.0 2.2e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK39395.2 - 7.2e-12 45.1 0.0 1.4e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK39395.2 - 1.2e-09 37.8 0.4 2.3e-09 36.9 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK39395.2 - 0.0076 16.0 0.1 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 EDK39395.2 - 0.0081 15.8 0.3 0.059 13.1 0.0 2.4 1 1 1 2 2 2 1 Limkain b1 CENP-B_dimeris PF09026.5 EDK39395.2 - 0.95 9.7 7.2 1.9 8.7 5.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 EDK39395.2 - 3.2 7.3 9.8 0.3 10.6 3.0 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Cyt-b5 PF00173.23 EDK39396.1 - 3.9e-25 87.4 0.3 4.7e-25 87.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NMO PF03060.10 EDK39397.2 - 2.8e-58 197.6 0.0 3.2e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 EDK39397.2 - 2.3e-05 23.4 0.0 0.06 12.2 0.0 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 EDK39397.2 - 0.0083 15.0 0.0 0.026 13.3 0.0 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase PcrB PF01884.12 EDK39397.2 - 0.013 14.7 0.0 0.12 11.6 0.0 2.1 2 0 0 2 2 2 0 PcrB family Aldolase PF01081.14 EDK39397.2 - 0.05 12.7 0.1 0.18 10.9 0.0 1.9 2 0 0 2 2 2 0 KDPG and KHG aldolase Cys_Met_Meta_PP PF01053.15 EDK39398.1 - 1.1e-62 211.6 0.0 4.2e-62 209.6 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 EDK39398.1 - 1.6e-05 23.8 0.0 2.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EDK39398.1 - 0.0055 15.7 0.0 0.008 15.1 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II DUF2493 PF10686.4 EDK39398.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2493) MFS_1 PF07690.11 EDK39399.1 - 3.3e-21 75.3 29.4 2.6e-20 72.4 11.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39399.1 - 9.1e-19 67.3 22.5 1.3e-18 66.8 15.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Methyltransf_PK PF05891.7 EDK39401.2 - 1.5e-78 263.0 0.0 1.7e-78 262.8 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Sld5 PF05916.6 EDK39402.2 - 1.5e-14 54.2 0.2 2e-14 53.8 0.2 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.12 EDK39403.2 - 2.3e-25 86.3 6.7 0.0053 16.5 0.0 11.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_11 PF13414.1 EDK39403.2 - 1.4e-24 85.5 22.7 4.6e-06 26.1 0.0 10.1 7 3 2 11 11 11 6 TPR repeat TPR_19 PF14559.1 EDK39403.2 - 4.5e-24 84.5 5.0 1.7e-05 25.0 0.0 11.3 10 3 3 13 13 13 5 Tetratricopeptide repeat TPR_1 PF00515.23 EDK39403.2 - 1.5e-22 78.1 8.9 0.0076 15.8 0.0 11.3 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_12 PF13424.1 EDK39403.2 - 7.5e-21 73.8 6.1 0.00068 19.5 0.1 9.9 6 4 2 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 EDK39403.2 - 1.2e-16 60.8 0.0 0.00043 20.8 0.0 8.6 7 2 1 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 EDK39403.2 - 1.2e-14 52.8 23.7 0.02 14.6 0.1 11.8 13 0 0 13 13 13 5 Tetratricopeptide repeat TPR_14 PF13428.1 EDK39403.2 - 2e-14 52.7 0.5 0.75 10.5 0.0 11.2 7 3 4 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.1 EDK39403.2 - 9.8e-08 31.6 10.3 3.4 8.0 0.0 10.1 13 0 0 13 13 12 2 Tetratricopeptide repeat Apc3 PF12895.2 EDK39403.2 - 1.7e-06 28.0 12.0 0.019 15.0 0.1 6.2 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EDK39403.2 - 4.6e-05 23.5 20.3 1 9.9 0.0 11.5 14 0 0 14 14 13 1 Tetratricopeptide repeat TPR_7 PF13176.1 EDK39403.2 - 0.00013 21.4 5.2 0.91 9.4 0.0 7.7 9 0 0 9 9 8 1 Tetratricopeptide repeat V_ATPase_I PF01496.14 EDK39403.2 - 2.2 6.0 14.7 7.1 4.3 10.2 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.6 EDK39404.2 - 4.7e-103 344.2 5.9 9.3e-103 343.3 4.1 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.1 EDK39404.2 - 9.1e-18 63.6 0.0 2.6e-17 62.1 0.0 1.8 1 0 0 1 1 1 1 Spc7_C2 Spc7_N PF15402.1 EDK39404.2 - 7.6e-08 30.8 25.0 9.9e-05 20.5 15.1 2.1 1 1 1 2 2 2 2 N-terminus of kinetochore NMS complex subunit Spc7 ADIP PF11559.3 EDK39404.2 - 0.0048 16.8 3.7 1.5 8.6 0.5 2.6 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding HR1 PF02185.11 EDK39404.2 - 0.17 11.6 7.7 6.9 6.4 0.9 3.7 2 1 1 3 3 3 0 Hr1 repeat Fib_alpha PF08702.5 EDK39404.2 - 0.76 9.8 9.4 0.046 13.8 2.1 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family PEX11 PF05648.9 EDK39405.1 - 1e-70 237.5 0.4 1.1e-70 237.3 0.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF3484 PF11983.3 EDK39406.2 - 1.5 9.7 7.7 8.4 7.3 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3484) CFEM PF05730.6 EDK39407.2 - 0.00074 19.2 5.8 0.0012 18.5 4.0 1.5 1 0 0 1 1 1 1 CFEM domain ALG3 PF05208.8 EDK39408.2 - 6.3e-103 344.8 28.6 7.8e-103 344.5 19.9 1.1 1 0 0 1 1 1 1 ALG3 protein LisH PF08513.6 EDK39409.2 - 4.2e-07 29.4 0.0 7.4e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 LisH WD40 PF00400.27 EDK39410.2 - 1.6e-29 100.6 2.7 2.7e-06 27.0 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Apc4_WD40 PF12894.2 EDK39410.2 - 0.024 14.1 0.0 0.093 12.2 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.3 EDK39410.2 - 0.068 11.2 0.1 7.9 4.4 0.0 2.3 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Voltage_CLC PF00654.15 EDK39411.2 - 1.1e-77 261.4 21.5 3.9e-77 259.6 14.8 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 EDK39411.2 - 0.06 13.1 2.2 0.19 11.5 0.1 2.8 3 0 0 3 3 3 0 CBS domain AAR2 PF05282.6 EDK39412.2 - 8.6e-78 261.7 5.8 1.1e-77 261.5 4.0 1.0 1 0 0 1 1 1 1 AAR2 protein DUF1074 PF06382.6 EDK39413.2 - 0.017 15.0 0.6 0.025 14.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1074) HMG_box_2 PF09011.5 EDK39413.2 - 0.026 14.9 2.4 0.039 14.3 0.1 2.3 2 0 0 2 2 2 0 HMG-box domain HMG_box PF00505.14 EDK39413.2 - 0.046 13.9 0.2 0.046 13.9 0.1 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box DUF3348 PF11828.3 EDK39413.2 - 0.058 12.8 0.7 0.073 12.4 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3348) Arrestin_C PF02752.17 EDK39414.2 - 9.5e-12 45.1 0.0 9.5e-12 45.1 0.0 2.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EDK39414.2 - 5.5e-06 26.2 0.0 0.004 16.9 0.0 2.7 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain NAD_binding_2 PF03446.10 EDK39415.2 - 3e-39 134.4 0.0 4.3e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EDK39415.2 - 5.5e-17 61.9 0.0 9.6e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 EDK39415.2 - 0.07 13.5 0.0 0.2 12.0 0.0 1.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.17 EDK39415.2 - 0.14 12.6 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold BPL_LplA_LipB PF03099.14 EDK39416.2 - 2.3e-17 63.1 0.0 4.5e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family UPF0086 PF01868.11 EDK39417.2 - 1.5e-11 43.7 0.0 5.9e-09 35.4 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function UPF0086 Vps51 PF08700.6 EDK39418.2 - 9.2e-07 28.6 2.1 3.7e-06 26.6 1.5 2.1 1 1 0 1 1 1 1 Vps51/Vps67 YmgB PF10798.3 EDK39418.2 - 0.1 12.4 0.3 0.31 10.8 0.1 1.9 2 0 0 2 2 2 0 Biofilm development protein YmgB/AriR PUF PF00806.14 EDK39419.2 - 1.5e-56 184.8 7.8 1.3e-07 30.7 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat HTH_16 PF12645.2 EDK39419.2 - 0.14 12.1 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Fungal_trans_2 PF11951.3 EDK39420.2 - 4.4e-15 55.1 1.1 4.2e-14 51.9 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39420.2 - 8.2e-07 28.8 12.5 1.7e-06 27.8 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ERG4_ERG24 PF01222.12 EDK39421.2 - 2.5e-161 537.0 26.5 2.8e-161 536.8 18.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family CytoC_RC PF02276.13 EDK39421.2 - 0.084 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit Proteasome PF00227.21 EDK39422.1 - 3.1e-36 124.4 0.0 3.5e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Hist_deacetyl PF00850.14 EDK39423.2 - 1.4e-80 270.9 0.0 1.8e-80 270.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase PF00069.20 EDK39424.2 - 2.3e-61 207.2 0.9 3e-61 206.8 0.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39424.2 - 7.3e-35 120.2 0.1 1.2e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39424.2 - 3.8e-05 22.8 0.0 6e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 EDK39424.2 - 0.043 13.1 0.4 0.081 12.2 0.3 1.4 1 0 0 1 1 1 0 RIO1 family Rhodanese PF00581.15 EDK39425.2 - 5.6e-13 49.2 0.0 1.3e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain adh_short PF00106.20 EDK39426.2 - 4.5e-67 225.1 5.3 1.2e-33 116.3 0.5 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EDK39426.2 - 6.5e-34 117.1 2.4 2.2e-17 63.3 0.3 2.2 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.14 EDK39426.2 - 4.7e-33 113.1 0.0 1.4e-32 111.6 0.0 1.8 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 EDK39426.2 - 0.00011 21.9 0.0 0.015 15.1 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Epimerase PF01370.16 EDK39426.2 - 0.058 12.8 1.9 1.6 8.1 0.1 2.4 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family CENP-B_dimeris PF09026.5 EDK39426.2 - 0.14 12.4 7.7 0.3 11.3 5.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nucleoplasmin PF03066.10 EDK39426.2 - 0.14 11.6 5.2 0.31 10.5 3.6 1.6 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 EDK39426.2 - 1.7 8.9 6.9 3.2 8.1 4.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Acyltransferase PF01553.16 EDK39427.2 - 4.4e-09 35.8 0.0 7.1e-08 31.9 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase DNA_ligase_A_M PF01068.16 EDK39428.1 - 1.4e-60 204.1 0.4 2.5e-60 203.3 0.3 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 EDK39428.1 - 2.1e-54 183.9 0.1 4.3e-54 183.0 0.1 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 EDK39428.1 - 5e-26 90.9 0.0 1.1e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 EDK39428.1 - 0.0017 17.9 0.7 1.5 8.5 0.0 2.5 2 0 0 2 2 2 2 DNA ligase OB-like domain Actin PF00022.14 EDK39429.2 - 3.3e-19 68.5 0.0 2.2e-18 65.8 0.0 1.9 1 1 0 1 1 1 1 Actin Aa_trans PF01490.13 EDK39430.2 - 0.062 11.7 1.2 0.085 11.3 0.8 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein Histone PF00125.19 EDK39431.2 - 2.3e-30 104.5 0.3 3.9e-30 103.7 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EDK39431.2 - 5.6e-05 23.2 0.0 8.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EDK39431.2 - 0.0014 18.6 1.0 0.0041 17.1 0.3 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 EDK39431.2 - 0.015 14.5 0.1 0.024 13.9 0.0 1.3 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T DUF1358 PF07096.6 EDK39432.2 - 0.019 14.6 0.9 0.026 14.1 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1358) G3P_acyltransf PF02660.10 EDK39432.2 - 0.22 11.0 2.1 0.28 10.7 1.4 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase 2OG-FeII_Oxy_2 PF13532.1 EDK39433.2 - 3e-25 89.1 0.1 5.3e-25 88.3 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.7 EDK39433.2 - 0.0095 15.8 7.3 0.019 14.8 5.1 1.5 1 0 0 1 1 1 1 GRF zinc finger CUE PF02845.11 EDK39433.2 - 0.014 14.9 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 CUE domain Zn_ribbon_recom PF13408.1 EDK39433.2 - 0.031 14.5 0.7 0.1 12.8 0.5 1.9 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Tetraspannin PF00335.15 EDK39435.2 - 0.014 14.6 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Tetraspanin family TarH PF02203.10 EDK39435.2 - 0.09 12.6 0.3 0.25 11.1 0.1 1.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF4446 PF14584.1 EDK39435.2 - 0.097 12.5 0.3 0.14 11.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Anoctamin PF04547.7 EDK39435.2 - 0.12 10.9 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel Alg6_Alg8 PF03155.10 EDK39436.2 - 5.6e-68 229.8 24.4 9.5e-68 229.1 16.9 1.3 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Alg6_Alg8 PF03155.10 EDK39437.2 - 3.1e-43 148.3 0.1 3.8e-43 148.0 0.1 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family GCR1_C PF12550.3 EDK39438.2 - 3.3e-14 52.5 0.1 8.2e-14 51.2 0.1 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Rsa3 PF14615.1 EDK39438.2 - 0.11 11.7 2.9 0.44 9.8 0.1 2.8 3 0 0 3 3 3 0 Ribosome-assembly protein 3 DUF1635 PF07795.6 EDK39438.2 - 0.26 10.6 3.1 0.36 10.1 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Rad4 PF03835.10 EDK39439.2 - 3.4e-11 42.7 0.2 6.7e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 EDK39439.2 - 1.8e-07 31.3 0.4 4.5e-07 30.0 0.3 1.7 1 1 0 1 1 1 1 Transglutaminase-like superfamily Tsg PF04668.7 EDK39439.2 - 0.94 9.6 5.0 12 6.0 0.9 2.7 3 0 0 3 3 3 0 Twisted gastrulation (Tsg) protein conserved region Zn_Tnp_IS1595 PF12760.2 EDK39439.2 - 0.97 9.2 4.4 12 5.8 3.2 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF3556 PF12077.3 EDK39440.2 - 0.059 11.3 0.8 0.068 11.1 0.5 1.0 1 0 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) tRNA-synt_1b PF00579.20 EDK39441.2 - 7e-71 238.7 0.0 1.1e-70 238.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) HA2 PF04408.18 EDK39442.2 - 1.2e-17 63.7 0.5 3.5e-17 62.2 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EDK39442.2 - 3.6e-15 55.7 0.0 8.5e-15 54.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EDK39442.2 - 1.9e-14 53.2 0.0 1.2e-13 50.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK39442.2 - 2.8e-07 30.1 0.2 6.7e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK39442.2 - 2e-06 27.9 1.0 4e-06 27.0 0.1 1.9 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 EDK39442.2 - 0.00067 19.4 0.1 0.0025 17.5 0.1 2.0 1 0 0 1 1 1 1 Archaeal ATPase AAA_29 PF13555.1 EDK39442.2 - 0.0028 17.1 0.0 0.0074 15.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 EDK39442.2 - 0.038 13.1 0.0 0.086 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_30 PF13604.1 EDK39442.2 - 0.078 12.5 0.7 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EDK39442.2 - 0.086 12.2 1.0 3.9 6.8 0.0 2.7 3 0 0 3 3 3 0 AAA-like domain ABC_tran PF00005.22 EDK39442.2 - 0.086 13.1 0.1 0.086 13.1 0.1 3.4 2 1 2 4 4 4 0 ABC transporter FtsK_SpoIIIE PF01580.13 EDK39442.2 - 0.12 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Inositol_P PF00459.20 EDK39443.2 - 6.8e-58 196.1 0.8 1.6e-57 194.8 0.6 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family DUF3985 PF13153.1 EDK39443.2 - 0.029 14.1 0.9 0.054 13.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3985) SUR7 PF06687.7 EDK39444.2 - 1.2e-50 171.9 5.8 1.6e-50 171.6 4.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family TAS2R PF05296.8 EDK39444.2 - 0.024 13.5 0.1 0.024 13.5 0.0 2.1 2 0 0 2 2 2 0 Mammalian taste receptor protein (TAS2R) LRR19-TM PF15176.1 EDK39444.2 - 0.12 12.0 0.2 0.74 9.5 0.0 2.3 1 1 1 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF2417 PF10329.4 EDK39444.2 - 0.23 10.8 2.9 0.41 10.0 0.1 2.1 2 0 0 2 2 2 0 Region of unknown function (DUF2417) ABC2_membrane_4 PF12730.2 EDK39444.2 - 3 6.9 13.1 0.57 9.3 0.1 2.6 3 0 0 3 3 3 0 ABC-2 family transporter protein Tht1 PF04163.7 EDK39446.2 - 4.3e-21 74.9 18.7 2.9e-20 72.1 12.7 1.9 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Laminin_II PF06009.7 EDK39446.2 - 0.14 11.9 2.8 0.3 10.8 0.8 2.5 2 1 0 3 3 3 0 Laminin Domain II DUF2015 PF09435.5 EDK39446.2 - 4.3 7.1 9.7 0.13 12.0 0.9 2.8 4 1 0 4 4 4 0 Fungal protein of unknown function (DUF2015) Lipase_3 PF01764.20 EDK39448.2 - 4.9e-29 100.7 0.0 6.8e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EDK39448.2 - 0.00033 20.4 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EDK39448.2 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.8 EDK39448.2 - 0.0034 17.0 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 EDK39448.2 - 0.0035 17.2 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK39448.2 - 0.027 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.15 EDK39448.2 - 0.077 13.2 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain DUF1057 PF06342.7 EDK39448.2 - 0.11 11.2 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.8 EDK39448.2 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold BRCT PF00533.21 EDK39449.2 - 2.3e-06 27.6 0.2 0.034 14.2 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ribosomal_L1 PF00687.16 EDK39450.2 - 1.3e-52 178.3 7.0 2e-52 177.6 4.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Calcipressin PF04847.7 EDK39451.2 - 1.3e-14 54.2 0.0 1.9e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Calcipressin RabGAP-TBC PF00566.13 EDK39452.2 - 3.2e-35 121.5 11.3 5.2e-32 111.0 2.8 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Metallophos PF00149.23 EDK39453.2 - 3.7e-10 39.5 9.3 7.7e-10 38.4 6.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EDK39453.2 - 1.7e-07 31.1 0.6 2.8e-07 30.5 0.4 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FBPase_2 PF06874.6 EDK39453.2 - 0.0019 16.3 0.3 0.042 11.9 0.1 2.0 1 1 1 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Rap1-DNA-bind PF09197.5 EDK39454.2 - 2.8e-35 121.0 1.7 2.3e-31 108.4 0.0 3.0 3 0 0 3 3 3 2 Rap1, DNA-binding Rap1_C PF11626.3 EDK39454.2 - 1.6e-21 76.0 0.1 2e-20 72.4 0.0 2.4 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 EDK39454.2 - 3.8e-05 23.3 0.9 0.33 10.7 0.0 3.2 3 0 0 3 3 3 2 Rap1 Myb domain Myb_DNA-binding PF00249.26 EDK39454.2 - 0.0029 17.6 0.2 2.6 8.1 0.0 3.3 2 1 0 2 2 2 2 Myb-like DNA-binding domain Glyco_hydro_17 PF00332.13 EDK39455.1 - 2.5e-07 30.0 1.1 6.3e-07 28.7 0.2 1.8 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 USP7_C2 PF14533.1 EDK39456.2 - 1.1e-55 188.3 3.1 1.8e-53 181.1 0.1 3.8 2 2 1 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 EDK39456.2 - 5.9e-52 176.4 1.6 5.9e-52 176.4 1.1 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 EDK39456.2 - 7.4e-38 130.2 4.4 7.4e-38 130.2 3.0 2.2 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.1 EDK39456.2 - 4.3e-34 118.3 0.9 2.8e-32 112.3 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 EDK39456.2 - 3.5e-13 49.8 2.2 2.1e-12 47.3 0.2 3.2 3 0 0 3 3 3 1 MATH domain Retinal PF15449.1 EDK39456.2 - 1.1 6.7 2.1 1.6 6.2 1.5 1.1 1 0 0 1 1 1 0 Retinal protein CTP_transf_2 PF01467.21 EDK39457.2 - 5.2e-13 49.3 0.0 1.7e-12 47.6 0.0 1.8 2 0 0 2 2 2 1 Cytidylyltransferase COG2 PF06148.6 EDK39457.2 - 0.0023 17.8 0.3 0.013 15.3 0.0 2.0 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 PPR_2 PF13041.1 EDK39458.2 - 4.6e-15 55.3 0.0 9.8e-13 47.8 0.0 3.0 3 0 0 3 3 3 2 PPR repeat family MA3 PF02847.12 EDK39459.2 - 2.2e-17 62.7 0.6 5.1e-16 58.3 0.1 2.6 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.14 EDK39459.2 - 7.8e-11 41.7 1.2 7.8e-11 41.7 0.8 1.8 2 0 0 2 2 2 1 MIF4G domain Bac_DnaA_C PF08299.6 EDK39459.2 - 0.048 13.5 0.2 0.29 11.0 0.0 2.4 2 1 1 3 3 3 0 Bacterial dnaA protein helix-turn-helix DUF2922 PF11148.3 EDK39459.2 - 0.052 13.2 0.2 0.32 10.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Cytochrom_C PF00034.16 EDK39460.1 - 6.3e-09 36.5 0.0 9.5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 EDK39460.1 - 3.4e-07 30.3 0.8 4.4e-06 26.7 0.6 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 EDK39460.1 - 0.011 15.2 0.3 0.15 11.5 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c-550 domain Cytochrom_C1 PF02167.10 EDK39460.1 - 0.021 14.4 0.0 0.031 13.9 0.0 1.3 1 1 0 1 1 1 0 Cytochrome C1 family Phosducin PF02114.11 EDK39461.2 - 2.9e-18 65.5 0.2 3.4e-18 65.3 0.2 1.1 1 0 0 1 1 1 1 Phosducin UCH PF00443.24 EDK39462.2 - 1.3e-57 194.9 8.4 1.3e-57 194.9 5.8 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK39462.2 - 2.4e-32 112.5 8.0 3.7e-32 111.9 5.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 EDK39462.2 - 4.8e-15 55.4 13.6 4.8e-15 55.4 9.4 3.1 2 1 1 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein DUF483 PF04467.7 EDK39462.2 - 0.078 13.0 0.1 4 7.5 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF483) ABC_tran PF00005.22 EDK39463.2 - 4e-09 36.9 0.0 6.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 EDK39463.2 - 0.00036 19.8 0.1 0.00045 19.5 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK39463.2 - 0.01 15.8 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain ABC_membrane PF00664.18 EDK39464.2 - 8.3e-56 189.3 34.5 1.5e-35 123.0 11.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK39464.2 - 1e-13 51.7 0.0 1.4e-12 48.0 0.0 2.7 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 EDK39464.2 - 0.0016 17.9 0.1 0.0045 16.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 EDK39464.2 - 0.0035 16.6 0.6 0.49 9.5 0.4 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EDK39464.2 - 0.018 15.8 0.0 0.055 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.1 EDK39464.2 - 0.063 13.2 7.5 1.6 8.6 0.3 3.6 3 1 1 4 4 4 0 AAA domain T2SE PF00437.15 EDK39464.2 - 0.09 11.6 0.2 0.22 10.3 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.1 EDK39464.2 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 EDK39464.2 - 0.15 12.3 1.3 0.6 10.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain PI31_Prot_C PF08577.6 EDK39465.2 - 2.1e-14 53.9 10.8 4.4e-14 52.8 7.5 1.6 1 0 0 1 1 1 1 PI31 proteasome regulator Glucosamine_iso PF01182.15 EDK39466.1 - 2.2e-50 171.1 0.0 3e-50 170.7 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase WD40 PF00400.27 EDK39467.2 - 1.1e-41 139.2 19.3 4.7e-08 32.6 0.0 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 EDK39467.2 - 2.1e-08 33.3 4.2 0.074 11.7 0.2 4.4 1 1 4 5 5 5 3 Nup133 N terminal like SBBP PF06739.6 EDK39467.2 - 0.22 11.3 0.2 0.22 11.3 0.1 2.7 3 0 0 3 3 3 0 Beta-propeller repeat DUF4632 PF15451.1 EDK39467.2 - 0.23 11.3 0.9 0.47 10.4 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) MOZ_SAS PF01853.13 EDK39468.2 - 1.7e-83 278.5 3.5 1.3e-77 259.2 0.3 2.4 2 0 0 2 2 2 2 MOZ/SAS family Tudor-knot PF11717.3 EDK39468.2 - 1.3e-21 76.0 0.5 3.1e-21 74.8 0.4 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PTPA PF03095.10 EDK39469.2 - 1.6e-116 388.6 0.4 2e-116 388.4 0.3 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein LETM1 PF07766.8 EDK39470.2 - 0.062 12.3 6.8 0.06 12.3 0.7 2.4 1 1 1 2 2 2 0 LETM1-like protein Clp1 PF06807.9 EDK39471.2 - 5.6e-19 68.6 0.4 3.3e-18 66.1 0.1 2.2 2 1 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 EDK39471.2 - 0.0045 16.7 0.0 0.011 15.4 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EDK39471.2 - 0.026 14.4 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.12 EDK39471.2 - 0.032 13.7 0.2 0.32 10.4 0.1 2.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein LRR_4 PF12799.2 EDK39473.2 - 2.5e-24 84.4 59.5 8.2e-06 25.3 0.8 10.5 6 3 4 12 12 12 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK39473.2 - 1.5e-20 72.6 44.0 6e-05 22.7 2.7 8.4 3 2 8 11 11 11 9 Leucine rich repeat LRR_1 PF00560.28 EDK39473.2 - 2.1e-12 45.2 47.6 0.22 11.6 0.7 14.1 13 2 0 13 13 13 6 Leucine Rich Repeat LRR_5 PF13306.1 EDK39473.2 - 2.2e-05 24.1 3.0 0.01 15.5 0.1 3.5 3 1 0 3 3 3 2 Leucine rich repeats (6 copies) LRR_7 PF13504.1 EDK39473.2 - 5.4e-05 22.7 53.7 2.8 8.5 1.5 14.1 16 0 0 16 16 16 3 Leucine rich repeat LRR_6 PF13516.1 EDK39473.2 - 0.00011 21.8 60.3 0.22 11.7 0.1 14.0 15 1 1 16 16 16 3 Leucine Rich repeat DUF892 PF05974.7 EDK39473.2 - 0.032 14.0 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF892) FNIP PF05725.7 EDK39473.2 - 0.064 13.2 26.4 0.053 13.4 1.1 7.1 5 2 1 6 6 6 0 FNIP Repeat Frankia_peptide PF14407.1 EDK39473.2 - 0.091 12.5 0.0 24 4.7 0.0 2.8 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. NIF PF03031.13 EDK39474.2 - 4.9e-50 169.2 0.2 7.2e-50 168.7 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Mononeg_RNA_pol PF00946.14 EDK39474.2 - 0.0092 13.4 0.4 0.01 13.2 0.3 1.1 1 0 0 1 1 1 1 Mononegavirales RNA dependent RNA polymerase HAD_2 PF13419.1 EDK39474.2 - 0.094 12.9 0.1 2.2 8.4 0.0 2.1 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase GAPT PF11770.3 EDK39474.2 - 2.1 7.9 8.5 3.3 7.3 5.9 1.2 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) DUF2981 PF11200.3 EDK39474.2 - 3 6.8 15.5 4.1 6.3 10.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) WD40 PF00400.27 EDK39475.2 - 8.2e-37 123.7 7.5 3.8e-07 29.7 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Sof1 PF04158.9 EDK39475.2 - 4.6e-33 113.0 9.6 9.8e-33 112.0 6.7 1.6 1 0 0 1 1 1 1 Sof1-like domain Pkinase PF00069.20 EDK39476.2 - 9.6e-59 198.6 0.1 1.1e-53 182.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39476.2 - 3e-18 65.8 0.0 6.9e-18 64.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EDK39476.2 - 0.038 13.7 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 EDK39476.2 - 0.079 11.9 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Ist1 PF03398.9 EDK39477.2 - 4.3e-62 208.3 0.6 5.8e-62 207.9 0.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway WD40 PF00400.27 EDK39478.2 - 2.6e-59 195.1 19.9 3.9e-11 42.3 0.3 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 EDK39478.2 - 4e-06 25.2 3.8 0.014 13.5 0.1 3.7 2 1 1 3 3 3 3 Nucleoporin Nup120/160 DUF3972 PF13118.1 EDK39478.2 - 0.12 12.4 0.3 0.24 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Rhodanese PF00581.15 EDK39479.1 - 1.3e-16 60.9 0.0 1.9e-08 34.6 0.0 2.6 2 1 0 2 2 2 2 Rhodanese-like domain Ribosomal_L37 PF08561.5 EDK39479.1 - 0.023 14.2 0.1 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 TruD PF01142.13 EDK39480.2 - 2e-67 227.4 0.7 6.7e-63 212.6 0.0 4.2 2 2 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) DUF1697 PF08002.6 EDK39480.2 - 0.013 15.5 0.5 0.037 14.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) Cytadhesin_P30 PF07271.6 EDK39480.2 - 2 7.6 5.4 3.1 6.9 3.7 1.3 1 0 0 1 1 1 0 Cytadhesin P30/P32 RRM_5 PF13893.1 EDK39481.2 - 0.032 14.0 0.0 8.8 6.2 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.18 EDK39482.2 - 3.6e-93 311.9 0.4 6.3e-93 311.1 0.3 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF641 PF04859.7 EDK39482.2 - 6.6 6.4 13.7 0.73 9.5 0.7 3.9 1 1 3 4 4 4 0 Plant protein of unknown function (DUF641) Pkinase PF00069.20 EDK39483.2 - 2.9e-77 259.3 0.0 4.3e-77 258.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39483.2 - 1.1e-38 132.7 0.0 2.2e-38 131.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase FHA PF00498.21 EDK39483.2 - 1.7e-29 101.7 0.5 3.9e-15 55.7 0.1 2.8 2 0 0 2 2 2 2 FHA domain Kinase-like PF14531.1 EDK39483.2 - 2.4e-08 33.3 0.0 8.9e-08 31.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK39483.2 - 7.1e-05 21.9 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK39483.2 - 0.00057 19.6 0.0 0.05 13.3 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kelch_4 PF13418.1 EDK39483.2 - 0.045 13.5 0.1 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Galactose oxidase, central domain RIO1 PF01163.17 EDK39483.2 - 0.046 13.0 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PNP_UDP_1 PF01048.15 EDK39484.1 - 1e-33 116.2 0.0 1.3e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DAGAT PF03982.8 EDK39486.2 - 1.1e-54 185.1 4.9 6e-26 90.8 0.0 4.1 3 1 0 3 3 3 3 Diacylglycerol acyltransferase ORC3_N PF07034.6 EDK39487.2 - 1.1e-29 103.4 1.8 1.8e-29 102.7 0.2 2.0 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus AAA_22 PF13401.1 EDK39487.2 - 0.0075 16.4 2.4 0.021 14.9 0.2 2.8 3 0 0 3 3 3 1 AAA domain Fmp27_WPPW PF10359.4 EDK39488.2 - 0.026 12.9 0.1 0.035 12.5 0.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Med9 PF07544.8 EDK39488.2 - 0.17 11.6 1.7 5.5 6.8 0.4 2.6 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Mannosyl_trans3 PF11051.3 EDK39489.2 - 1.5e-71 240.9 0.6 1.5e-71 240.9 0.4 1.8 2 0 0 2 2 2 1 Mannosyltransferase putative MR_MLE_C PF13378.1 EDK39490.2 - 2.5e-20 72.5 0.0 2e-19 69.6 0.0 2.1 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EDK39490.2 - 1.8e-12 47.5 0.0 4e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EDK39490.2 - 1e-08 35.1 0.0 1.6e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans PF04082.13 EDK39491.2 - 7.7e-24 83.9 0.0 1.3e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39491.2 - 2.3e-06 27.4 13.1 3.9e-06 26.6 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 5_nucleotid PF05761.9 EDK39491.2 - 0.023 13.2 0.0 0.034 12.6 0.0 1.2 1 0 0 1 1 1 0 5' nucleotidase family DHDPS PF00701.17 EDK39492.1 - 3.4e-43 147.3 0.0 3.9e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family adh_short_C2 PF13561.1 EDK39493.2 - 1.8e-26 93.4 0.0 2.2e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK39493.2 - 6.2e-26 91.3 0.5 8e-26 90.9 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK39493.2 - 4.1e-10 39.6 0.2 5.9e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 EDK39493.2 - 0.07 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 EDK39493.2 - 0.08 12.0 0.2 0.29 10.2 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Bac_rhamnosid PF05592.6 EDK39494.1 - 2.1e-25 88.9 1.8 2.1e-23 82.3 0.5 2.2 2 1 0 2 2 2 2 Bacterial alpha-L-rhamnosidase DUF608 PF04685.8 EDK39494.1 - 5.8e-08 31.8 0.3 1.1e-07 30.9 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF608 Trehalase PF01204.13 EDK39494.1 - 5.9e-07 28.4 0.0 9.4e-07 27.8 0.0 1.2 1 0 0 1 1 1 1 Trehalase MORN PF02493.15 EDK39494.1 - 0.071 12.8 0.4 0.35 10.6 0.0 2.5 2 0 0 2 2 2 0 MORN repeat Prenyltrans_1 PF13243.1 EDK39494.1 - 0.13 12.3 1.0 0.32 11.0 0.0 2.2 3 0 0 3 3 3 0 Prenyltransferase-like Sugar_tr PF00083.19 EDK39496.2 - 5e-51 173.6 14.6 6.2e-51 173.3 10.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter AA_permease PF00324.16 EDK39497.2 - 1.1e-141 472.4 42.6 1.3e-141 472.2 29.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK39497.2 - 1.2e-37 129.4 43.6 1.7e-37 129.0 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease Proteasome PF00227.21 EDK39498.2 - 2e-47 160.9 1.6 2.2e-47 160.7 1.1 1.0 1 0 0 1 1 1 1 Proteasome subunit RasGEF_N_2 PF14663.1 EDK39498.2 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Pro_isomerase PF00160.16 EDK39499.2 - 1e-38 132.9 0.1 1.4e-38 132.5 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 EDK39500.2 - 8.8e-17 60.5 0.0 1.2e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK39500.2 - 6.7e-13 48.4 0.0 9.4e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK39500.2 - 4.5e-10 39.2 0.0 5.8e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribophorin_I PF04597.9 EDK39501.2 - 2.2e-135 451.5 3.2 2.5e-135 451.3 2.2 1.0 1 0 0 1 1 1 1 Ribophorin I Rotamase PF00639.16 EDK39502.2 - 5.6e-24 84.6 0.2 9.8e-24 83.9 0.0 1.4 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 EDK39502.2 - 5.2e-18 65.4 0.0 6.4e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 EDK39502.2 - 2.9e-09 36.6 0.3 5.2e-09 35.8 0.2 1.4 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.1 EDK39502.2 - 1.7e-06 28.6 0.0 2.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain ADK PF00406.17 EDK39503.2 - 2.8e-46 157.1 0.0 3.6e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_33 PF13671.1 EDK39503.2 - 3.1e-10 40.0 0.0 4.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK39503.2 - 9.5e-10 38.8 0.0 1.4e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK39503.2 - 6.1e-07 30.2 0.0 9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 EDK39503.2 - 1.3e-05 24.6 0.5 0.081 12.2 0.0 2.2 1 1 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.7 EDK39503.2 - 0.005 15.9 0.0 0.0069 15.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin SRP54 PF00448.17 EDK39503.2 - 0.012 15.0 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain adh_short PF00106.20 EDK39504.2 - 7.8e-31 107.2 3.6 9.7e-31 106.9 2.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK39504.2 - 2.1e-14 53.5 2.1 2.9e-14 53.1 1.4 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EDK39504.2 - 3.6e-14 53.1 0.2 4.7e-14 52.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 EDK39504.2 - 3.7e-05 23.2 0.5 0.00017 21.1 0.4 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EDK39504.2 - 0.00087 19.2 0.1 0.0016 18.3 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.10 EDK39504.2 - 0.0049 15.7 0.2 0.0068 15.3 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 EDK39504.2 - 0.044 13.7 3.2 0.15 12.0 2.1 1.9 1 1 0 1 1 1 0 NADH(P)-binding NAD_binding_4 PF07993.7 EDK39504.2 - 0.097 11.5 0.6 0.89 8.4 0.4 2.6 1 1 0 1 1 1 0 Male sterility protein Pkinase PF00069.20 EDK39505.2 - 7e-54 182.6 0.3 1.5e-53 181.5 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39505.2 - 1.6e-19 69.9 0.1 4.1e-18 65.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EDK39505.2 - 0.016 14.3 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SUN PF03856.8 EDK39507.2 - 2.8e-101 338.0 20.2 2.8e-101 338.0 14.0 1.5 2 0 0 2 2 2 1 Beta-glucosidase (SUN family) zf-MYND PF01753.13 EDK39507.2 - 0.13 12.1 2.2 0.32 10.9 1.5 1.6 1 0 0 1 1 1 0 MYND finger Sporozoite_P67 PF05642.6 EDK39507.2 - 0.4 8.4 10.6 0.74 7.6 7.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Herpes_capsid PF06112.6 EDK39507.2 - 5.2 7.0 13.9 12 5.9 9.6 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein MSP1_C PF07462.6 EDK39507.2 - 6.5 5.0 7.0 8.6 4.6 4.9 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Kinetochor_Ybp2 PF08568.5 EDK39508.2 - 3.4e-166 554.2 16.6 4.3e-166 553.8 11.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin APG12 PF04110.8 EDK39509.2 - 2.7e-25 88.3 0.0 5.2e-25 87.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.11 EDK39509.2 - 0.00083 19.3 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like HTH_22 PF13309.1 EDK39509.2 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 HTH domain TFIIE_alpha PF02002.12 EDK39510.2 - 6.4e-23 80.2 1.3 3e-22 78.1 0.3 2.2 2 0 0 2 2 2 1 TFIIE alpha subunit Rab_eff_C PF04698.7 EDK39510.2 - 3.5e-05 22.1 5.5 4.8e-05 21.7 3.8 1.1 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus Zn_Tnp_IS1595 PF12760.2 EDK39510.2 - 0.0035 17.0 0.4 0.0086 15.8 0.3 1.6 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DZR PF12773.2 EDK39510.2 - 0.02 14.7 0.3 0.039 13.7 0.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon DUF2688 PF10892.3 EDK39510.2 - 0.036 13.7 0.2 0.076 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) zf-FPG_IleRS PF06827.9 EDK39510.2 - 0.048 13.3 0.3 4.1 7.1 0.1 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS OrfB_Zn_ribbon PF07282.6 EDK39510.2 - 0.07 12.8 0.3 0.14 11.8 0.2 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF2387 PF09526.5 EDK39510.2 - 0.094 12.6 1.7 0.16 11.9 0.1 2.2 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) HTH_9 PF08221.6 EDK39510.2 - 0.1 12.4 0.1 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain zf-TFIIB PF13453.1 EDK39510.2 - 0.14 11.3 0.5 0.33 10.1 0.4 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger DiS_P_DiS PF06750.8 EDK39510.2 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain AAA_18 PF13238.1 EDK39510.2 - 0.15 12.3 1.0 9 6.6 0.0 2.9 3 1 0 3 3 3 0 AAA domain Zn-ribbon_8 PF09723.5 EDK39510.2 - 0.23 11.4 1.2 1.5 8.8 0.8 2.1 1 1 2 3 3 3 0 Zinc ribbon domain Fork_head PF00250.13 EDK39511.2 - 2.7e-34 117.0 0.4 5.6e-34 116.0 0.2 1.5 1 0 0 1 1 1 1 Fork head domain DUF3686 PF12458.3 EDK39511.2 - 0.13 10.4 0.0 0.3 9.2 0.0 1.4 2 0 0 2 2 2 0 ATPase involved in DNA repair G10 PF01125.12 EDK39512.1 - 1.7e-60 202.7 7.9 2e-60 202.5 5.5 1.0 1 0 0 1 1 1 1 G10 protein Ribosomal_L38e PF01781.13 EDK39512.1 - 0.012 15.4 0.5 0.019 14.6 0.3 1.3 1 0 0 1 1 1 0 Ribosomal L38e protein family DUF2387 PF09526.5 EDK39512.1 - 4.9 7.1 9.1 8.1 6.4 1.1 2.5 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) HEAT PF02985.17 EDK39513.2 - 0.0042 17.0 0.0 0.81 9.9 0.0 3.5 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.3 EDK39513.2 - 0.0057 16.0 0.2 0.35 10.2 0.1 2.3 2 0 0 2 2 2 2 CLASP N terminal Pkinase_Tyr PF07714.12 EDK39513.2 - 0.0074 15.3 0.0 0.046 12.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase OPT PF03169.10 EDK39514.2 - 2.6e-170 567.9 47.3 3e-170 567.6 32.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein OPT PF03169.10 EDK39516.2 - 1.3e-171 572.2 46.3 1.5e-171 572.0 32.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein YtzH PF14165.1 EDK39516.2 - 0.055 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 YtzH-like protein OPT PF03169.10 EDK39517.2 - 3.4e-170 567.5 51.8 3.9e-170 567.3 35.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ribosomal_L13 PF00572.13 EDK39521.1 - 2.4e-27 95.4 0.1 4.6e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L13 HMGL-like PF00682.14 EDK39522.2 - 8.8e-69 231.7 0.0 1.3e-68 231.2 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 EDK39522.2 - 2.7e-29 101.6 1.3 5.3e-29 100.7 0.9 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain RRM_1 PF00076.17 EDK39523.2 - 4.3e-09 35.8 0.0 8.4e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK39523.2 - 0.0036 17.2 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Trypan_PARP PF05887.6 EDK39524.2 - 0.26 11.0 26.0 0.11 12.3 0.9 3.1 3 0 0 3 3 3 0 Procyclic acidic repetitive protein (PARP) SPX PF03105.14 EDK39524.2 - 4.1 7.1 20.4 5.3 6.7 14.1 1.2 1 0 0 1 1 1 0 SPX domain Daxx PF03344.10 EDK39524.2 - 4.3 5.7 32.3 1.3 7.3 4.9 2.2 2 0 0 2 2 2 0 Daxx Family Serinc PF03348.10 EDK39524.2 - 6.2 5.4 10.5 2.5 6.7 1.4 2.0 1 1 1 2 2 2 0 Serine incorporator (Serinc) PRP1_N PF06424.7 EDK39524.2 - 6.3 7.1 12.9 21 5.4 0.2 2.3 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Arrestin_N PF00339.24 EDK39525.2 - 1.1e-12 47.9 0.2 4.1e-12 46.1 0.0 2.1 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 EDK39525.2 - 3.4e-06 27.2 7.1 2.2e-05 24.5 0.0 4.0 2 2 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Kelch_5 PF13854.1 EDK39526.2 - 2.5e-31 107.1 17.7 9.9e-08 31.7 0.3 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 EDK39526.2 - 5.9e-30 102.7 7.4 3.2e-07 30.3 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.1 EDK39526.2 - 4.7e-29 99.8 18.7 1.8e-08 34.0 0.1 6.5 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 EDK39526.2 - 7.7e-26 89.1 12.0 1.2e-07 31.6 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 EDK39526.2 - 2.1e-18 65.5 15.8 3.7e-09 35.9 0.0 6.2 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 EDK39526.2 - 1.6e-15 56.1 8.0 3.6e-06 26.5 0.1 6.1 6 0 0 6 6 6 3 Kelch motif TSC22 PF01166.13 EDK39526.2 - 0.0075 16.2 2.3 0.0075 16.2 1.6 5.3 5 0 0 5 5 5 3 TSC-22/dip/bun family Vps53_N PF04100.7 EDK39527.2 - 2.5e-52 177.9 12.0 4.9e-52 176.9 8.3 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.8 EDK39527.2 - 1.5e-05 23.3 8.8 0.00016 19.9 6.0 2.3 1 1 0 1 1 1 1 Exocyst complex component Sec6 PRAI PF00697.17 EDK39528.2 - 1.2e-42 145.6 0.3 2.1e-39 135.1 0.1 2.0 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Cpn60_TCP1 PF00118.19 EDK39529.2 - 1.4e-137 459.2 10.0 1.6e-137 459.0 6.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.12 EDK39529.2 - 0.0036 17.3 0.1 0.099 12.7 0.0 2.8 3 0 0 3 3 3 1 Dinitrogenase iron-molybdenum cofactor Sec2p PF06428.6 EDK39530.2 - 2e-29 101.4 11.5 2e-29 101.4 8.0 3.2 2 1 1 3 3 3 1 GDP/GTP exchange factor Sec2p FH2 PF02181.18 EDK39531.2 - 2.3e-84 283.4 13.7 2.3e-84 283.4 9.5 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.11 EDK39531.2 - 2.8e-45 154.1 0.6 2.8e-45 154.1 0.4 4.4 5 0 0 5 5 5 2 Diaphanous FH3 Domain Drf_GBD PF06371.8 EDK39531.2 - 1.4e-38 132.1 0.6 1.4e-38 132.1 0.4 4.2 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain MMS1_N PF10433.4 EDK39532.2 - 3.4e-126 421.3 0.3 5.8e-126 420.5 0.2 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PQQ_3 PF13570.1 EDK39532.2 - 0.022 15.0 0.0 17 5.8 0.0 3.7 3 0 0 3 3 3 0 PQQ-like domain Sugar_tr PF00083.19 EDK39533.2 - 1e-26 93.5 7.7 1.3e-26 93.2 5.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39533.2 - 1.2e-16 60.4 11.9 1.4e-16 60.1 8.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.15 EDK39533.2 - 0.08 10.9 3.0 0.16 9.9 2.1 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3902 PF13042.1 EDK39533.2 - 0.61 9.3 6.1 4.7 6.4 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3902) Sugar_tr PF00083.19 EDK39534.2 - 9.1e-13 47.5 11.0 1.2e-12 47.1 7.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39534.2 - 2.8e-10 39.4 10.6 3.9e-10 38.9 7.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4191 PF13829.1 EDK39534.2 - 5.4 6.0 5.3 0.76 8.8 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Yip1 PF04893.12 EDK39535.2 - 1.7e-08 34.1 0.8 2e-08 33.9 0.5 1.0 1 0 0 1 1 1 1 Yip1 domain PPR_2 PF13041.1 EDK39536.2 - 3.4e-08 33.3 1.0 0.00016 21.5 0.0 4.2 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.15 EDK39536.2 - 4e-05 23.3 0.2 5.2 7.2 0.0 5.2 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.1 EDK39536.2 - 8e-05 22.6 0.1 0.022 14.9 0.0 4.7 4 0 0 4 4 4 1 Pentatricopeptide repeat domain DUF4279 PF14106.1 EDK39536.2 - 0.042 13.7 0.0 12 5.8 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) HTH_38 PF13936.1 EDK39536.2 - 0.056 13.0 0.2 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain TPR_12 PF13424.1 EDK39536.2 - 0.11 12.4 6.5 2 8.3 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat SPC22 PF04573.7 EDK39537.2 - 5.9e-44 149.3 0.3 7.2e-44 149.1 0.2 1.0 1 0 0 1 1 1 1 Signal peptidase subunit tRNA-synt_1e PF01406.14 EDK39538.2 - 2.9e-134 446.9 0.1 2.9e-134 446.9 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 EDK39538.2 - 6.1e-08 31.7 8.6 2.2e-05 23.3 0.1 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 EDK39538.2 - 6.8e-05 21.0 0.0 6.8e-05 21.0 0.0 2.9 3 1 0 3 3 3 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.16 EDK39538.2 - 0.055 12.1 4.4 0.45 9.1 0.0 2.7 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF4647 PF15504.1 EDK39538.2 - 2.6 6.8 15.7 4 6.1 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Ribosomal_L14e PF01929.12 EDK39539.1 - 9.6e-31 105.9 3.3 1.4e-30 105.4 2.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 DUF3341 PF11821.3 EDK39540.2 - 0.028 13.8 3.2 0.027 13.9 1.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) MRP_L53 PF10780.4 EDK39540.2 - 0.26 11.3 0.9 8.3 6.4 0.0 2.3 2 0 0 2 2 2 0 39S ribosomal protein L53/MRP-L53 GTP_EFTU PF00009.22 EDK39541.2 - 5e-60 202.1 0.1 1.1e-59 201.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 EDK39541.2 - 2.4e-33 114.2 0.0 6.9e-33 112.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 EDK39541.2 - 9.4e-31 105.4 0.0 2.2e-30 104.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 EDK39541.2 - 6.6e-22 77.1 0.0 1.6e-21 75.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 EDK39541.2 - 4.5e-12 45.9 0.1 1.4e-11 44.3 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 EDK39541.2 - 0.0052 17.2 0.0 0.013 15.9 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 EDK39541.2 - 0.0076 16.1 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GCR1_C PF12550.3 EDK39541.2 - 0.046 13.5 0.1 0.17 11.7 0.0 2.0 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes DUF3376 PF11856.3 EDK39541.2 - 0.18 11.1 0.1 0.27 10.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3376) FA_desaturase PF00487.19 EDK39542.2 - 4.1e-19 69.0 25.0 8.1e-19 68.0 17.4 1.4 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 EDK39542.2 - 8.3e-09 35.5 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Chitin_synth_2 PF03142.10 EDK39545.2 - 9.3e-288 954.8 0.7 9.3e-288 954.8 0.5 1.6 2 0 0 2 2 2 1 Chitin synthase Glyco_tranf_2_3 PF13641.1 EDK39545.2 - 4.4e-20 72.4 0.0 3.6e-17 62.9 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 EDK39545.2 - 7.9e-20 71.3 2.6 3.1e-19 69.4 1.8 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 EDK39545.2 - 1.4e-06 27.6 0.1 8e-06 25.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 EDK39545.2 - 2.6e-06 27.2 0.0 1.4e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Cyt-b5 PF00173.23 EDK39545.2 - 3.8e-06 26.5 0.0 0.0023 17.6 0.0 3.4 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Sec7_N PF12783.2 EDK39547.2 - 4.8e-43 146.5 4.8 1.2e-42 145.1 3.4 1.7 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal CAP59_mtransfer PF11735.3 EDK39547.2 - 0.054 12.7 0.6 0.52 9.4 0.1 2.2 2 0 0 2 2 2 0 Cryptococcal mannosyltransferase 1 PP2C PF00481.16 EDK39548.2 - 3e-34 118.5 0.0 4.5e-22 78.6 0.0 3.7 2 1 1 3 3 3 3 Protein phosphatase 2C PP2C_2 PF13672.1 EDK39548.2 - 0.0019 17.6 0.0 0.0043 16.4 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Ribosomal_S19 PF00203.16 EDK39549.1 - 5.3e-23 80.4 0.0 6.9e-23 80.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Rho_GDI PF02115.12 EDK39549.1 - 0.095 12.1 0.1 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor DEAD PF00270.24 EDK39550.2 - 1.3e-38 132.1 0.0 3e-38 130.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39550.2 - 2e-19 69.2 0.3 4e-19 68.2 0.2 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK39550.2 - 4.6e-09 36.3 0.0 4.6e-09 36.3 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Trypan_PARP PF05887.6 EDK39550.2 - 0.025 14.3 10.0 0.064 13.0 6.9 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AAA_22 PF13401.1 EDK39550.2 - 0.53 10.4 3.5 1.8 8.6 0.9 3.1 2 1 0 2 2 2 0 AAA domain Daxx PF03344.10 EDK39550.2 - 7.7 4.8 22.2 11 4.3 15.4 1.1 1 0 0 1 1 1 0 Daxx Family SNF2_N PF00176.18 EDK39551.2 - 2.7e-72 243.1 0.1 5.8e-72 241.9 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK39551.2 - 1.6e-14 53.5 0.0 4.5e-14 52.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain V_ATPase_I PF01496.14 EDK39551.2 - 9.4 3.9 9.4 22 2.7 6.5 1.6 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Suc_Fer-like PF06999.7 EDK39552.2 - 2.5e-47 161.8 0.0 2.9e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like KilA-N PF04383.8 EDK39553.2 - 5.2e-06 26.0 0.4 7.1e-05 22.4 0.0 2.7 2 1 0 2 2 2 1 KilA-N domain SAGA-Tad1 PF12767.2 EDK39553.2 - 0.56 9.8 17.6 1.1 8.8 12.2 1.6 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Bap31 PF05529.7 EDK39554.2 - 1.3e-49 168.2 2.7 2.2e-49 167.5 1.9 1.3 1 1 0 1 1 1 1 B-cell receptor-associated protein 31-like Med28 PF11594.3 EDK39554.2 - 0.067 13.4 1.1 0.11 12.7 0.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 28 CorA PF01544.13 EDK39555.2 - 4.3e-40 137.5 2.2 8.2e-20 71.0 0.0 3.2 2 1 1 3 3 3 3 CorA-like Mg2+ transporter protein A_thal_3526 PF09713.5 EDK39555.2 - 0.066 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) DUF3484 PF11983.3 EDK39555.2 - 0.59 11.0 4.1 2 9.3 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3484) Aldo_ket_red PF00248.16 EDK39556.2 - 2e-43 148.2 0.0 2.9e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Rotamase PF00639.16 EDK39556.2 - 0.13 13.0 0.2 0.26 12.0 0.1 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain FCH PF00611.18 EDK39557.2 - 1.7e-18 66.5 0.0 1.7e-18 66.5 0.0 2.9 3 1 1 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 EDK39557.2 - 3.6e-10 39.0 0.0 7.3e-10 38.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK39557.2 - 4.2e-10 39.0 0.1 9.5e-10 37.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK39557.2 - 4.7e-05 22.7 0.0 8.6e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ipi1_N PF12333.3 EDK39557.2 - 0.11 12.4 1.0 4.9 7.1 0.0 3.2 2 1 1 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation MCM_N PF14551.1 EDK39557.2 - 0.82 10.1 3.9 0.41 11.1 0.6 2.1 2 0 0 2 2 2 0 MCM N-terminal domain DUF4137 PF13593.1 EDK39558.2 - 4.7e-122 406.9 18.8 5.4e-122 406.7 13.0 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Motilin_assoc PF04643.7 EDK39558.2 - 0.068 12.6 0.1 0.2 11.1 0.1 1.8 2 0 0 2 2 2 0 Motilin/ghrelin-associated peptide COG6 PF06419.6 EDK39559.2 - 1.5e-184 614.6 18.6 2.1e-184 614.1 12.9 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Cloacin PF03515.9 EDK39560.2 - 0.66 9.1 4.4 1.2 8.3 3.1 1.4 1 0 0 1 1 1 0 Colicin-like bacteriocin tRNase domain Iso_dh PF00180.15 EDK39561.2 - 2.3e-73 247.1 0.0 2.7e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Med11 PF10280.4 EDK39562.2 - 0.13 12.2 2.7 0.24 11.4 0.5 2.4 2 1 0 2 2 2 0 Mediator complex protein COX7C PF02935.11 EDK39563.1 - 7.4e-18 64.1 4.5 8.8e-18 63.8 3.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Sec1 PF00995.18 EDK39565.2 - 1.3e-39 136.3 5.1 2e-39 135.6 3.5 1.4 1 0 0 1 1 1 1 Sec1 family 4HBT_3 PF13622.1 EDK39566.2 - 1.2e-27 97.2 0.0 1.6e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EDK39566.2 - 2.5e-12 46.5 0.0 1.8e-10 40.5 0.0 2.4 2 1 0 2 2 2 1 Acyl-CoA thioesterase AP2 PF00847.15 EDK39566.2 - 0.14 12.3 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 AP2 domain 4HBT_3 PF13622.1 EDK39567.2 - 2.2e-26 93.1 0.0 3.4e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 EDK39567.2 - 3.4e-12 46.1 3.4 4.8e-11 42.4 0.0 2.9 3 1 0 3 3 3 2 Acyl-CoA thioesterase MFS_1 PF07690.11 EDK39568.2 - 2.7e-36 125.0 28.3 2.7e-36 125.0 19.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily ADH_zinc_N PF00107.21 EDK39569.2 - 1.6e-14 53.5 0.4 2.9e-14 52.7 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK39569.2 - 8.2e-05 22.3 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AAA_5 PF07728.9 EDK39570.2 - 1.2e-127 420.2 0.1 2.3e-22 79.2 0.0 10.0 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 EDK39570.2 - 7.3e-32 109.7 0.0 8.4e-09 35.1 0.0 8.2 8 0 0 8 8 8 5 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 EDK39570.2 - 2.5e-28 98.8 0.4 6e-05 23.2 0.0 7.6 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 EDK39570.2 - 1e-23 83.9 2.6 0.0003 20.8 0.0 7.8 8 0 0 8 8 7 4 Sigma-54 interaction domain AAA_14 PF13173.1 EDK39570.2 - 4.9e-23 81.4 4.2 0.00052 19.9 0.0 9.7 9 1 0 10 10 9 4 AAA domain AAA_16 PF13191.1 EDK39570.2 - 1.9e-22 80.1 5.4 0.0016 18.4 0.0 7.6 7 0 0 7 7 6 5 AAA ATPase domain Sigma54_activat PF00158.21 EDK39570.2 - 3.9e-20 71.9 0.2 0.0019 17.6 0.1 6.6 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_22 PF13401.1 EDK39570.2 - 1e-19 70.9 4.2 0.0046 17.0 0.0 7.9 7 1 0 7 7 6 4 AAA domain AAA_33 PF13671.1 EDK39570.2 - 1.7e-17 63.6 0.2 0.056 13.3 0.0 7.1 6 1 0 6 6 6 4 AAA domain AAA_17 PF13207.1 EDK39570.2 - 3e-15 57.1 29.9 0.00057 20.6 0.0 9.3 8 1 0 8 8 6 5 AAA domain T2SE PF00437.15 EDK39570.2 - 9.9e-14 50.8 2.7 0.029 13.2 0.1 6.4 6 0 0 6 6 6 3 Type II/IV secretion system protein UPF0079 PF02367.12 EDK39570.2 - 3.5e-13 49.2 7.3 0.013 15.1 0.2 6.8 6 0 0 6 6 6 3 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 EDK39570.2 - 1.4e-11 44.5 6.6 0.2 11.8 0.0 8.1 8 0 0 8 8 7 3 RNA helicase AAA_19 PF13245.1 EDK39570.2 - 4.3e-11 42.4 5.8 0.3 10.8 0.0 6.5 6 0 0 6 6 6 2 Part of AAA domain AAA_18 PF13238.1 EDK39570.2 - 4.6e-11 43.1 32.5 0.029 14.6 0.0 10.8 9 1 0 9 9 7 4 AAA domain AAA_28 PF13521.1 EDK39570.2 - 1.1e-10 41.7 9.1 0.39 10.6 0.0 7.7 7 0 0 7 7 7 2 AAA domain NACHT PF05729.7 EDK39570.2 - 3e-10 39.9 3.0 0.18 11.4 0.0 5.9 5 0 0 5 5 5 2 NACHT domain Miro PF08477.8 EDK39570.2 - 6.8e-10 39.4 9.8 0.11 13.0 0.1 7.5 7 0 0 7 7 7 2 Miro-like protein PduV-EutP PF10662.4 EDK39570.2 - 3.2e-09 36.4 3.8 0.084 12.3 0.0 6.1 6 0 0 6 6 6 2 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 EDK39570.2 - 1.2e-08 34.7 4.3 0.19 11.4 0.0 6.5 6 0 0 6 6 6 2 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 EDK39570.2 - 1.2e-08 35.3 24.7 0.0076 16.5 0.0 8.0 7 1 0 7 7 6 2 ABC transporter DUF258 PF03193.11 EDK39570.2 - 1.9e-08 33.6 9.2 0.47 9.6 0.6 6.3 6 0 0 6 6 6 3 Protein of unknown function, DUF258 AAA_25 PF13481.1 EDK39570.2 - 2e-08 33.8 3.4 0.54 9.6 0.1 5.6 6 0 0 6 6 5 2 AAA domain Mg_chelatase PF01078.16 EDK39570.2 - 4.8e-08 32.4 5.8 6.9 5.7 0.1 8.6 8 1 0 9 9 9 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 EDK39570.2 - 3.1e-07 29.7 3.0 2 7.3 0.0 6.7 8 1 0 8 8 7 1 Holliday junction DNA helicase ruvB N-terminus AAA_29 PF13555.1 EDK39570.2 - 7.7e-07 28.5 7.8 0.64 9.5 0.0 6.4 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_7 PF12775.2 EDK39570.2 - 8.2e-06 25.0 4.4 0.76 8.8 0.1 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region D3 IstB_IS21 PF01695.12 EDK39570.2 - 1e-05 25.0 4.8 0.61 9.4 0.0 6.4 8 0 0 8 8 7 1 IstB-like ATP binding protein SRP54 PF00448.17 EDK39570.2 - 2.7e-05 23.6 7.0 0.16 11.3 0.3 5.0 5 0 0 5 5 5 2 SRP54-type protein, GTPase domain PhoH PF02562.11 EDK39570.2 - 4.3e-05 22.8 1.4 0.89 8.7 0.0 4.6 5 0 0 5 5 5 2 PhoH-like protein CPT PF07931.7 EDK39570.2 - 6.5e-05 22.6 0.8 11 5.6 0.0 5.9 7 0 0 7 7 7 0 Chloramphenicol phosphotransferase-like protein ATP-synt_ab PF00006.20 EDK39570.2 - 7.6e-05 22.3 0.0 1.2 8.6 0.0 5.1 5 2 1 6 6 6 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_6 PF12774.2 EDK39570.2 - 0.00046 19.7 0.0 3.3 7.1 0.0 4.7 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region D1 NTPase_1 PF03266.10 EDK39570.2 - 0.0011 18.7 5.3 4.8 6.8 0.4 5.6 5 0 0 5 5 5 0 NTPase FtsK_SpoIIIE PF01580.13 EDK39570.2 - 0.012 15.1 5.2 5.4 6.4 0.1 4.7 4 0 0 4 4 4 0 FtsK/SpoIIIE family TPP_enzyme_N PF02776.13 EDK39570.2 - 1.7 8.0 0.0 8 5.9 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PP2C_2 PF13672.1 EDK39571.2 - 6.1e-10 38.8 0.0 9.1e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 EDK39571.2 - 3e-08 33.5 0.0 4.9e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 EDK39571.2 - 1.2e-06 28.1 0.6 0.036 13.4 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C EPSP_synthase PF00275.15 EDK39572.2 - 1.3e-128 429.0 0.1 1.8e-128 428.5 0.1 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHquinase_I PF01487.10 EDK39572.2 - 5.3e-63 212.6 0.0 1.1e-62 211.6 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 EDK39572.2 - 3.2e-33 114.8 0.0 7e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.6 EDK39572.2 - 5.7e-24 83.9 0.0 1.6e-23 82.5 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 EDK39572.2 - 2.8e-13 50.1 0.0 8.1e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_17 PF13207.1 EDK39572.2 - 3.4e-08 34.3 0.0 1.1e-07 32.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EDK39572.2 - 0.0052 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EDK39572.2 - 0.0063 16.3 0.0 0.017 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EDK39572.2 - 0.033 14.0 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain 6PF2K PF01591.13 EDK39572.2 - 0.076 12.0 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DHQ_synthase PF01761.15 EDK39573.2 - 6.4e-78 261.2 0.1 9.9e-78 260.6 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 EDK39573.2 - 1.2e-09 37.8 0.0 1.7e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 EDK39573.2 - 6.8e-07 28.2 0.1 9.4e-07 27.7 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase PolyA_pol PF01743.15 EDK39574.2 - 6.6e-16 58.6 0.1 1.8e-15 57.2 0.1 1.8 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 EDK39574.2 - 1.3e-10 40.6 0.0 3.2e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 EDK39574.2 - 7.9e-07 28.9 0.1 1.7e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative DNA_repr_REX1B PF14966.1 EDK39575.2 - 0.1 12.9 1.1 0.25 11.7 0.1 2.1 2 0 0 2 2 2 0 DNA repair REX1-B ArfGap PF01412.13 EDK39576.2 - 9.9e-29 99.5 4.4 1.5e-28 98.8 0.6 2.7 1 1 1 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.24 EDK39576.2 - 3.1e-12 46.6 0.1 8.9e-12 45.1 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 EDK39576.2 - 2.4e-05 24.4 4.1 7.2e-05 22.9 0.5 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.1 EDK39576.2 - 0.00047 20.1 0.1 0.0012 18.9 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Glyoxalase PF00903.20 EDK39576.2 - 0.048 13.6 0.1 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PH_11 PF15413.1 EDK39576.2 - 0.12 12.5 1.9 0.82 9.9 0.7 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Pkinase PF00069.20 EDK39577.2 - 8.7e-69 231.5 0.0 1.1e-68 231.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39577.2 - 2.2e-48 164.6 0.0 2.9e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39577.2 - 0.019 13.9 0.0 0.036 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.6 EDK39577.2 - 0.028 13.2 0.5 0.3 9.8 0.4 2.3 2 1 0 2 2 2 0 Seadornavirus VP7 RIO1 PF01163.17 EDK39577.2 - 0.029 13.6 0.2 0.079 12.2 0.2 1.7 1 1 0 1 1 1 0 RIO1 family DUF1548 PF07579.6 EDK39578.2 - 0.17 12.0 2.3 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) XPG_I PF00867.13 EDK39579.2 - 2.9e-23 81.7 0.0 7.6e-23 80.3 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EDK39579.2 - 4.2e-23 81.5 0.0 1.2e-22 80.1 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 EDK39579.2 - 0.00051 19.5 0.0 0.0017 17.9 0.0 1.8 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 EDK39579.2 - 0.0016 18.6 0.0 0.0074 16.5 0.0 2.2 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Phospho_p8 PF10195.4 EDK39579.2 - 0.027 14.3 0.9 0.068 13.0 0.6 1.6 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 HHH PF00633.18 EDK39579.2 - 0.064 12.9 0.0 20 5.1 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif IFT57 PF10498.4 EDK39580.2 - 0.15 10.8 10.1 0.21 10.3 7.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SOBP PF15279.1 EDK39580.2 - 4.2 7.6 15.5 6.2 7.1 10.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CGI-121 PF08617.5 EDK39581.1 - 4e-41 140.3 1.0 4.5e-41 140.2 0.7 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 WASH-7_mid PF14744.1 EDK39581.1 - 0.036 12.8 0.1 0.056 12.2 0.0 1.2 1 0 0 1 1 1 0 WASH complex subunit 7 MAT1 PF06391.8 EDK39582.2 - 8.7e-48 162.5 25.9 1e-47 162.3 18.0 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4 PF00097.20 EDK39582.2 - 0.0014 18.2 4.2 0.0036 16.9 2.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK39582.2 - 0.002 17.7 4.8 0.0036 16.9 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK39582.2 - 0.022 14.5 5.4 0.047 13.5 3.8 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 EDK39582.2 - 0.024 14.6 7.6 0.07 13.1 5.3 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-piccolo PF05715.8 EDK39582.2 - 0.026 14.5 0.8 0.059 13.3 0.6 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger Prominin PF05478.6 EDK39582.2 - 0.077 10.5 14.6 0.11 10.0 10.1 1.2 1 0 0 1 1 1 0 Prominin zf-RING_5 PF14634.1 EDK39582.2 - 0.094 12.4 8.8 0.8 9.4 6.3 2.2 1 1 1 2 2 2 0 zinc-RING finger domain Fibrillarin PF01269.12 EDK39582.2 - 0.11 11.3 3.3 0.9 8.4 2.0 2.1 2 0 0 2 2 2 0 Fibrillarin zf-RING_UBOX PF13445.1 EDK39582.2 - 0.15 11.7 4.5 0.46 10.2 3.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Fucose_iso_N2 PF07882.7 EDK39582.2 - 1.4 8.5 7.0 4.1 7.0 4.9 1.9 1 1 0 1 1 1 0 L-fucose isomerase, second N-terminal domain FYDLN_acid PF09538.5 EDK39582.2 - 3.5 8.2 11.7 0.33 11.5 0.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF948 PF06103.6 EDK39582.2 - 3.6 7.5 5.6 1.1 9.1 0.4 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) zf-DHHC PF01529.15 EDK39583.2 - 6e-20 71.3 10.9 6e-20 71.3 7.6 1.5 1 1 0 1 1 1 1 DHHC palmitoyltransferase Adipogenin PF15202.1 EDK39583.2 - 0.16 11.8 1.7 0.35 10.7 1.1 1.6 1 0 0 1 1 1 0 Adipogenin DUF3270 PF11674.3 EDK39583.2 - 0.28 11.2 2.0 0.65 10.0 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) DUF4131 PF13567.1 EDK39583.2 - 8.3 5.7 10.2 3.7 6.9 4.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) zf-DHHC PF01529.15 EDK39584.2 - 0.008 15.5 0.1 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase B12D PF06522.6 EDK39584.2 - 0.094 12.4 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DNA_pol_lambd_f PF10391.4 EDK39584.2 - 0.11 12.0 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda RPAP1_C PF08620.5 EDK39585.2 - 9.4e-34 115.1 0.2 1.7e-32 111.0 0.0 2.3 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 EDK39585.2 - 2e-19 68.8 2.6 3.9e-19 67.9 1.8 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal Pmp3 PF01679.12 EDK39586.2 - 1.2e-18 66.4 8.4 1.4e-18 66.2 5.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator ADH_zinc_N_2 PF13602.1 EDK39587.2 - 2.8e-13 50.8 0.0 8e-13 49.3 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 EDK39587.2 - 3e-12 46.2 0.2 3e-11 42.9 0.0 2.4 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK39587.2 - 0.00015 21.5 0.8 0.00088 19.0 0.0 2.6 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.3 EDK39587.2 - 0.039 13.1 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Pkinase PF00069.20 EDK39588.2 - 3.8e-67 226.1 0.0 5.5e-67 225.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39588.2 - 1.8e-50 171.4 0.0 2.7e-50 170.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 EDK39588.2 - 4.4e-36 122.9 0.0 1.3e-35 121.5 0.0 1.8 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 EDK39588.2 - 2.8e-11 43.0 0.0 8.3e-11 41.5 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EDK39588.2 - 8.4e-11 41.8 0.0 2.3e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.1 EDK39588.2 - 1e-06 27.9 0.0 0.00036 19.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase PF00069.20 EDK39589.2 - 3.8e-39 134.4 0.0 1.9e-26 92.8 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39589.2 - 7.4e-18 64.5 0.0 7.7e-15 54.6 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 EDK39589.2 - 0.0025 17.1 0.8 0.016 14.6 0.0 2.5 3 1 1 4 4 4 1 RIO1 family APH PF01636.18 EDK39589.2 - 0.0034 17.1 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 EDK39589.2 - 0.033 13.2 0.0 0.077 12.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.15 EDK39589.2 - 0.039 13.0 0.1 0.099 11.7 0.0 1.6 2 0 0 2 2 2 0 Ecdysteroid kinase Sugar_tr PF00083.19 EDK39590.1 - 1.4e-112 376.5 23.4 1.6e-112 376.3 16.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39590.1 - 9.1e-23 80.5 40.2 7e-18 64.4 8.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Metallophos PF00149.23 EDK39591.2 - 1.1e-10 41.2 0.0 3.8e-10 39.5 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FlgH PF02107.11 EDK39591.2 - 0.3 10.6 4.3 0.54 9.7 3.0 1.3 1 0 0 1 1 1 0 Flagellar L-ring protein Sec62 PF03839.11 EDK39591.2 - 0.93 8.8 6.0 2.1 7.7 4.1 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 RNase_H2-Ydr279 PF09468.5 EDK39591.2 - 0.99 8.5 10.0 1.7 7.7 6.9 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF4337 PF14235.1 EDK39591.2 - 1.2 8.9 9.9 3.5 7.4 6.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) RR_TM4-6 PF06459.7 EDK39591.2 - 2 8.2 11.0 3.2 7.5 7.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CASP_C PF08172.7 EDK39592.2 - 6.8e-73 244.7 6.8 6.8e-73 244.7 4.7 3.7 2 1 1 3 3 3 1 CASP C terminal CENP-F_leu_zip PF10473.4 EDK39592.2 - 0.0082 16.0 12.7 0.0082 16.0 8.8 6.0 4 2 1 6 6 6 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 EDK39592.2 - 4.3 7.0 71.6 0.2 11.4 3.9 7.0 3 1 3 6 6 6 0 TPR/MLP1/MLP2-like protein Ribosomal_L21e PF01157.13 EDK39593.1 - 1.3e-28 98.6 6.7 1.3e-28 98.6 3.9 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.4 EDK39593.1 - 0.00014 21.3 0.0 0.00015 21.1 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 DUF1989 PF09347.5 EDK39593.1 - 0.045 13.1 0.0 0.062 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) ATP_bind_4 PF01902.12 EDK39595.2 - 4.8e-39 133.9 0.0 1.3e-38 132.5 0.0 1.7 1 1 0 1 1 1 1 ATP-binding region Ribonuc_L-PSP PF01042.16 EDK39595.2 - 1e-13 51.0 0.1 1e-05 25.2 0.0 2.6 3 0 0 3 3 3 2 Endoribonuclease L-PSP LicD PF04991.8 EDK39596.2 - 1.8e-49 168.6 1.6 1.8e-49 168.6 1.1 2.7 3 0 0 3 3 3 1 LicD family CN_hydrolase PF00795.17 EDK39597.2 - 5.8e-14 51.8 0.0 1e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase LicD PF04991.8 EDK39598.2 - 8.2e-52 176.2 0.0 8.2e-52 176.2 0.0 3.1 4 0 0 4 4 4 1 LicD family COX6A PF02046.10 EDK39599.1 - 8.1e-44 148.2 1.9 9.1e-44 148.0 1.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.27 EDK39601.2 - 2e-09 36.9 1.1 0.00061 19.5 0.1 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Ribosomal_S26e PF01283.14 EDK39602.1 - 1.2e-51 173.7 10.3 1.4e-51 173.5 7.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.2 EDK39602.1 - 0.03 14.7 0.7 0.21 11.9 0.2 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain mono-CXXC PF15626.1 EDK39602.1 - 0.07 13.0 1.0 0.07 13.0 0.7 2.0 2 0 0 2 2 2 0 single CXXC unit Fer4_10 PF13237.1 EDK39602.1 - 0.12 12.2 2.6 0.32 10.8 1.8 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain COX5B PF01215.14 EDK39603.2 - 1.3e-40 138.1 0.0 1.5e-40 138.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb 2-Hacid_dh_C PF02826.14 EDK39604.2 - 1.1e-40 138.6 0.0 1.6e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EDK39604.2 - 9.2e-15 54.2 0.0 1.1e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.12 EDK39604.2 - 0.00016 22.0 0.1 0.00055 20.3 0.1 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 EDK39604.2 - 0.00024 21.0 0.3 0.00047 20.0 0.1 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 EDK39604.2 - 0.00088 18.6 0.1 0.0014 18.0 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Rossmann-like PF10727.4 EDK39604.2 - 0.0042 16.7 0.2 0.01 15.5 0.0 1.6 2 0 0 2 2 2 1 Rossmann-like domain ApbA PF02558.11 EDK39604.2 - 0.015 14.7 0.1 0.029 13.8 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AdoHcyase_NAD PF00670.16 EDK39604.2 - 0.021 14.6 0.2 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.1 EDK39604.2 - 0.024 14.8 0.1 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.13 EDK39604.2 - 0.11 12.5 0.3 0.2 11.6 0.2 1.5 1 1 0 1 1 1 0 TrkA-N domain SH3_1 PF00018.23 EDK39605.2 - 6.5e-37 124.6 7.2 4.1e-12 45.3 0.0 4.5 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.7 EDK39605.2 - 7.1e-34 115.2 0.0 1.3e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.1 EDK39605.2 - 8.7e-33 111.6 5.4 7e-10 38.3 0.1 4.4 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 EDK39605.2 - 2.8e-30 103.5 0.1 9.2e-08 31.4 0.0 4.7 4 0 0 4 4 4 4 Variant SH3 domain P21-Arc PF04062.9 EDK39605.2 - 0.14 11.9 0.1 0.39 10.4 0.0 1.7 2 0 0 2 2 2 0 ARP2/3 complex ARPC3 (21 kDa) subunit MT-A70 PF05063.9 EDK39606.2 - 2.7e-49 167.1 0.2 4.2e-49 166.4 0.1 1.3 1 0 0 1 1 1 1 MT-A70 GcpE PF04551.9 EDK39606.2 - 0.14 10.9 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 GcpE protein DUF962 PF06127.6 EDK39607.2 - 2.8e-22 78.4 2.8 6.9e-22 77.1 1.9 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF962) STT3 PF02516.9 EDK39608.2 - 3e-138 461.7 39.9 1.3e-134 449.8 25.7 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.1 EDK39608.2 - 0.00098 19.0 13.2 0.00098 19.0 9.1 3.4 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase TPPK_C PF12555.3 EDK39608.2 - 9.5 6.0 13.7 7.4 6.3 0.0 3.5 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal FYVE PF01363.16 EDK39609.2 - 2.2e-15 56.3 6.6 3.9e-15 55.4 4.5 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.11 EDK39609.2 - 7 6.6 14.0 1.4 8.8 7.0 1.9 2 0 0 2 2 2 0 AN1-like Zinc finger FUN14 PF04930.10 EDK39610.1 - 2.2e-07 31.0 1.6 8.2e-07 29.2 1.1 2.0 1 1 0 1 1 1 1 FUN14 family ATPase_gene1 PF09527.5 EDK39610.1 - 0.65 9.8 6.6 3.8 7.3 0.4 3.2 2 1 1 3 3 3 0 Putative F0F1-ATPase subunit (ATPase_gene1) RNA_pol_Rpb1_5 PF04998.12 EDK39611.2 - 2.8e-97 325.2 0.0 2.9e-96 321.9 0.0 2.4 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EDK39611.2 - 4.6e-64 215.3 0.1 1.1e-63 214.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 EDK39611.2 - 1.9e-38 131.7 0.0 1.2e-37 129.0 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EDK39611.2 - 3.4e-24 84.6 0.1 2e-23 82.1 0.0 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 EDK39611.2 - 2.4e-23 82.9 12.0 8.8e-22 77.7 0.0 3.8 3 1 0 3 3 3 2 RNA polymerase Rpb1, domain 1 TFIIA PF03153.8 EDK39611.2 - 2.7 7.7 23.8 0.015 15.2 8.7 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Na_trans_assoc PF06512.8 EDK39611.2 - 3.6 7.5 20.8 5.2 6.9 11.6 2.8 3 0 0 3 3 3 0 Sodium ion transport-associated C2 PF00168.25 EDK39612.2 - 1.9e-50 168.6 2.2 1.6e-14 53.4 0.1 4.5 4 0 0 4 4 4 4 C2 domain SAPS PF04499.10 EDK39612.2 - 0.44 9.1 9.2 0.74 8.3 6.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ycf1 PF05758.7 EDK39612.2 - 0.66 7.6 10.5 1 7.0 7.3 1.2 1 0 0 1 1 1 0 Ycf1 Vfa1 PF08432.5 EDK39612.2 - 1.5 8.7 18.4 3.8 7.4 12.8 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.8 EDK39612.2 - 1.7 7.0 9.2 2.6 6.4 6.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.17 EDK39612.2 - 2.2 7.2 6.7 3.6 6.4 4.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.11 EDK39612.2 - 2.8 7.7 6.5 1.7 8.4 2.6 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GAGA_bind PF06217.7 EDK39612.2 - 3.2 7.6 8.8 5.4 6.9 6.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2201_N PF13203.1 EDK39612.2 - 6.3 5.8 10.4 11 5.0 7.2 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain CDC45 PF02724.9 EDK39612.2 - 7.2 4.5 14.5 11 3.8 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein LtrA PF06772.6 EDK39613.2 - 4.6e-29 101.4 10.2 4.6e-29 101.4 7.1 1.4 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) InaF-motif PF15018.1 EDK39613.2 - 0.0094 15.3 0.2 0.044 13.2 0.1 2.2 1 0 0 1 1 1 1 TRP-interacting helix DUF4491 PF14898.1 EDK39613.2 - 3.2 7.9 10.5 0.3 11.2 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) TMEM192 PF14802.1 EDK39613.2 - 4 6.2 8.4 0.15 10.9 0.9 2.2 2 1 0 2 2 2 0 TMEM192 family MRP-S25 PF13741.1 EDK39614.2 - 3.4e-92 308.1 0.2 4.4e-92 307.7 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.4 EDK39614.2 - 7.7e-05 22.6 0.1 0.0047 16.8 0.0 2.6 2 1 0 2 2 2 1 Mitochondrial ribosomal protein S23 ATP13 PF12921.2 EDK39615.2 - 0.0035 16.6 0.1 0.088 12.1 0.0 3.0 2 1 0 2 2 2 1 Mitochondrial ATPase expression PPR_2 PF13041.1 EDK39615.2 - 0.0036 17.2 0.0 3.9 7.5 0.0 3.3 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.1 EDK39615.2 - 0.032 14.5 0.0 4.8 7.7 0.0 3.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain MarR_2 PF12802.2 EDK39615.2 - 0.04 13.5 0.0 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 MarR family DUF3233 PF11557.3 EDK39616.2 - 0.0043 15.9 0.0 0.0043 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3233) OAD_gamma PF04277.8 EDK39616.2 - 0.097 13.0 0.5 0.19 12.1 0.3 1.7 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF1469 PF07332.6 EDK39616.2 - 0.098 12.3 1.0 0.17 11.6 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF350 PF03994.9 EDK39616.2 - 1.1 9.0 5.3 4 7.2 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF350) Frataxin_Cyay PF01491.11 EDK39617.1 - 1.4e-35 121.3 0.0 1.8e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain zf-MIZ PF02891.15 EDK39618.2 - 1.4e-10 40.4 1.8 1.2e-08 34.2 0.1 2.7 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger zf-Nse PF11789.3 EDK39618.2 - 2.4e-05 23.7 1.7 0.00029 20.2 0.0 2.6 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DUF21 PF01595.15 EDK39619.2 - 5.1e-32 110.6 0.1 9e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 EDK39619.2 - 0.00034 20.3 0.1 0.89 9.3 0.0 3.3 3 0 0 3 3 3 2 CBS domain Pkinase PF00069.20 EDK39620.2 - 5.9e-51 173.1 0.0 1e-50 172.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39620.2 - 7.8e-18 64.4 0.0 1.9e-17 63.2 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39620.2 - 0.017 14.1 0.0 0.042 12.8 0.0 1.7 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 EDK39620.2 - 0.051 13.3 1.5 0.097 12.3 0.1 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Solute_trans_a PF03619.11 EDK39621.2 - 1.8e-96 322.6 13.0 2.3e-96 322.3 9.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha mIF3 PF14877.1 EDK39622.2 - 2.4e-64 216.0 5.8 2.4e-64 216.0 4.0 1.8 2 0 0 2 2 2 1 Mitochondrial translation initiation factor Fe_hyd_lg_C PF02906.9 EDK39623.2 - 5.7e-69 232.5 0.0 9.2e-69 231.8 0.0 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Ytp1 PF10355.4 EDK39624.2 - 2.7e-74 249.7 9.0 4.4e-74 249.1 6.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) Peptidase_S8 PF00082.17 EDK39625.2 - 4.1e-52 177.0 1.9 4.1e-52 177.0 1.3 1.8 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 EDK39625.2 - 1.2e-24 85.9 0.2 2.5e-24 84.8 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Plasmodium_Vir PF05795.6 EDK39625.2 - 0.00015 21.1 1.2 0.00027 20.2 0.8 1.3 1 0 0 1 1 1 1 Plasmodium vivax Vir protein TMEM154 PF15102.1 EDK39625.2 - 0.013 15.1 0.1 0.032 13.9 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF4407 PF14362.1 EDK39625.2 - 0.31 9.9 2.2 0.54 9.1 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) G6PD_C PF02781.11 EDK39626.2 - 3.7e-130 433.0 0.0 5.5e-130 432.4 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 EDK39626.2 - 4.9e-65 219.1 0.1 9.3e-65 218.2 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain WD40 PF00400.27 EDK39627.2 - 0.0012 18.6 0.0 0.029 14.2 0.0 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat IKI3 PF04762.7 EDK39627.2 - 0.072 10.8 0.0 0.13 10.0 0.0 1.4 1 1 0 1 1 1 0 IKI3 family WD40 PF00400.27 EDK39628.2 - 4.2e-31 105.6 12.4 1.4e-06 27.9 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Glycos_transf_4 PF00953.16 EDK39629.2 - 2.3e-30 105.4 16.7 2.3e-30 105.4 11.6 2.3 2 1 0 2 2 2 1 Glycosyl transferase family 4 WD40 PF00400.27 EDK39631.2 - 1.9e-07 30.6 18.1 0.03 14.2 0.1 6.6 6 1 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.1 EDK39631.2 - 0.067 13.4 0.5 23 5.4 0.0 3.6 3 0 0 3 3 3 0 PQQ-like domain ELFV_dehydrog PF00208.16 EDK39632.2 - 9.9e-63 211.9 0.0 1.6e-62 211.2 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 EDK39632.2 - 1.6e-22 78.8 0.0 3.3e-17 61.3 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 EDK39632.2 - 0.0013 18.3 0.0 0.0034 16.9 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ubiquitin_3 PF14836.1 EDK39632.2 - 0.036 13.7 0.0 0.089 12.4 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Phage_int_SAM_4 PF13495.1 EDK39632.2 - 0.28 11.5 4.4 2.2 8.6 0.1 3.6 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain Pribosyl_synth PF14572.1 EDK39633.2 - 1.5e-39 135.6 0.1 2.2e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 EDK39633.2 - 1.1e-31 108.9 0.0 3.8e-31 107.2 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EDK39633.2 - 1e-10 41.4 0.0 2.6e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Adap_comp_sub PF00928.16 EDK39634.2 - 2.2e-72 243.3 0.1 2.6e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 EDK39634.2 - 1.2e-05 25.1 0.0 2.6e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain muHD PF10291.4 EDK39634.2 - 0.0098 15.0 0.0 0.021 14.0 0.0 1.6 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain CUE PF02845.11 EDK39635.2 - 1.3e-09 37.3 0.1 3.1e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 CUE domain UBA PF00627.26 EDK39635.2 - 0.03 14.1 0.0 0.074 12.9 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain Pho86 PF11124.3 EDK39636.2 - 1.4e-122 408.4 0.3 1.6e-122 408.2 0.2 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 Lectin_leg-like PF03388.8 EDK39637.2 - 3.9e-57 193.0 0.0 4.9e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.14 EDK39637.2 - 6.9e-05 22.3 0.0 0.0027 17.1 0.0 2.1 2 0 0 2 2 2 2 Legume lectin domain PDE8 PF08629.5 EDK39637.2 - 0.18 11.5 0.0 0.62 9.9 0.0 1.8 2 0 0 2 2 2 0 PDE8 phosphodiesterase YkyA PF10368.4 EDK39638.2 - 0.039 13.2 0.3 0.051 12.9 0.2 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein His_Phos_1 PF00300.17 EDK39639.1 - 4.1e-31 108.2 0.2 5e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 EDK39639.1 - 0.1 11.9 0.1 0.18 11.0 0.0 1.5 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) IU_nuc_hydro PF01156.14 EDK39640.2 - 2.7e-77 260.0 0.0 3e-77 259.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Abhydro_lipase PF04083.11 EDK39641.2 - 7.4e-16 57.2 0.0 1.2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_5 PF12695.2 EDK39641.2 - 0.021 14.5 0.0 0.034 13.9 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF3089 PF11288.3 EDK39641.2 - 0.023 13.8 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Mito_carr PF00153.22 EDK39642.2 - 2.1e-65 216.4 5.2 1.1e-21 76.3 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein 2-Hacid_dh_C PF02826.14 EDK39643.2 - 9.1e-51 171.5 0.0 1.3e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 EDK39643.2 - 6.6e-15 54.7 0.0 1.4e-14 53.6 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 EDK39643.2 - 1e-05 25.4 0.0 3.4e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 EDK39643.2 - 0.00037 20.8 0.0 0.00091 19.6 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.7 EDK39643.2 - 0.00068 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 EDK39643.2 - 0.0036 16.8 0.2 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.16 EDK39643.2 - 0.063 13.0 1.4 3.5 7.4 0.1 2.8 2 1 1 3 3 3 0 ThiF family DUF4056 PF13265.1 EDK39643.2 - 0.068 12.1 0.1 0.22 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4056) Peptidase_M28 PF04389.12 EDK39644.2 - 4.3e-34 117.8 0.0 7e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 EDK39644.2 - 1.7e-12 46.8 0.1 3.7e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.23 EDK39644.2 - 0.00081 18.9 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 EDK39644.2 - 0.0016 17.2 0.1 0.005 15.6 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase DnaJ PF00226.26 EDK39645.2 - 1.6e-22 79.0 3.0 5e-22 77.4 2.1 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 EDK39645.2 - 1.8e-05 24.2 2.9 0.25 11.3 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK39645.2 - 6.4e-05 22.4 0.8 0.32 10.8 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK39645.2 - 0.0011 18.5 10.1 0.0073 15.8 0.0 5.0 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.1 EDK39645.2 - 0.0051 16.4 5.2 0.18 11.4 0.0 4.2 4 0 0 4 4 4 1 TPR repeat PDGF_N PF04692.8 EDK39645.2 - 0.07 13.6 0.0 0.07 13.6 0.0 3.9 3 1 1 4 4 4 0 Platelet-derived growth factor, N terminal region Activator_LAG-3 PF11498.3 EDK39645.2 - 1.6 7.3 27.3 2.7 6.6 18.9 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 BAF1_ABF1 PF04684.8 EDK39645.2 - 7 5.3 20.6 12 4.5 14.3 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AAA PF00004.24 EDK39646.2 - 9e-43 145.6 0.0 1.7e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EDK39646.2 - 3.9e-07 29.8 0.0 1.1e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 EDK39646.2 - 9.4e-07 28.8 0.0 2e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 EDK39646.2 - 8.9e-06 25.8 0.2 0.00041 20.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK39646.2 - 6.9e-05 22.9 0.0 0.00024 21.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF2968 PF11180.3 EDK39646.2 - 0.00064 19.1 0.5 0.001 18.4 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) RuvB_N PF05496.7 EDK39646.2 - 0.00072 18.6 0.0 0.0013 17.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EDK39646.2 - 0.00073 19.4 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EDK39646.2 - 0.00081 18.8 0.0 0.0023 17.3 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 EDK39646.2 - 0.00085 19.0 0.0 0.0019 17.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 EDK39646.2 - 0.0012 19.6 0.1 0.0035 18.1 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.1 EDK39646.2 - 0.0031 17.3 0.0 0.007 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EDK39646.2 - 0.0043 16.1 0.0 0.029 13.4 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin ATG16 PF08614.6 EDK39646.2 - 0.0089 15.8 1.5 0.017 14.9 1.0 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) AAA_25 PF13481.1 EDK39646.2 - 0.011 15.1 0.1 0.063 12.6 0.0 2.0 1 1 0 2 2 2 0 AAA domain AAA_28 PF13521.1 EDK39646.2 - 0.011 15.6 0.3 0.031 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 EDK39646.2 - 0.016 14.4 0.0 0.033 13.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Filament PF00038.16 EDK39646.2 - 0.017 14.6 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 Intermediate filament protein AAA_3 PF07726.6 EDK39646.2 - 0.02 14.5 0.0 0.052 13.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 EDK39646.2 - 0.02 14.5 0.5 0.037 13.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain PhoH PF02562.11 EDK39646.2 - 0.022 14.0 0.0 0.067 12.4 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein TIP49 PF06068.8 EDK39646.2 - 0.022 13.4 0.0 0.043 12.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 C-terminus KaiC PF06745.8 EDK39646.2 - 0.026 13.6 0.0 0.072 12.1 0.0 1.7 1 0 0 1 1 1 0 KaiC Tropomyosin PF00261.15 EDK39646.2 - 0.028 13.4 3.0 0.029 13.4 0.8 1.8 2 0 0 2 2 2 0 Tropomyosin AAA_18 PF13238.1 EDK39646.2 - 0.031 14.6 0.4 0.13 12.5 0.0 2.3 3 1 0 3 3 3 0 AAA domain Cluap1 PF10234.4 EDK39646.2 - 0.031 13.4 0.9 0.053 12.7 0.6 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 RNA_helicase PF00910.17 EDK39646.2 - 0.033 14.3 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TMF_TATA_bd PF12325.3 EDK39646.2 - 0.044 13.5 0.8 0.11 12.2 0.2 2.0 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding DUF2072 PF09845.4 EDK39646.2 - 0.046 13.6 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) UvrD-helicase PF00580.16 EDK39646.2 - 0.05 12.8 0.2 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain NACHT PF05729.7 EDK39646.2 - 0.057 13.0 0.0 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_13 PF13166.1 EDK39646.2 - 0.06 11.7 0.7 0.63 8.4 0.3 2.0 2 0 0 2 2 2 0 AAA domain DivIC PF04977.10 EDK39646.2 - 0.074 12.5 1.5 0.17 11.4 1.1 1.5 1 0 0 1 1 1 0 Septum formation initiator HR1 PF02185.11 EDK39646.2 - 0.2 11.3 4.0 0.52 10.0 2.8 1.7 1 0 0 1 1 1 0 Hr1 repeat Neur_chan_memb PF02932.11 EDK39647.2 - 2 8.2 7.0 55 3.5 4.8 2.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MIF4G PF02854.14 EDK39648.2 - 2.4e-39 134.9 0.5 4.2e-39 134.1 0.4 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 EDK39648.2 - 2e-26 91.6 0.4 7.8e-26 89.7 0.3 2.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 AAA PF00004.24 EDK39649.2 - 1.3e-15 57.7 0.0 3.2e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EDK39649.2 - 2.5e-14 52.9 0.2 1.6e-13 50.2 0.1 2.3 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EDK39649.2 - 3.5e-08 34.2 0.2 7.4e-07 30.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EDK39649.2 - 2.4e-06 27.4 0.0 5.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EDK39649.2 - 1.2e-05 25.4 0.1 9.9e-05 22.4 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK39649.2 - 2e-05 24.8 0.5 0.0001 22.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 EDK39649.2 - 2.5e-05 24.1 0.1 9.2e-05 22.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain Rad17 PF03215.10 EDK39649.2 - 0.00017 20.4 0.0 0.31 9.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EDK39649.2 - 0.00021 21.3 0.2 0.0039 17.2 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EDK39649.2 - 0.00024 20.8 0.0 0.001 18.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 EDK39649.2 - 0.0015 18.0 0.0 0.31 10.5 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.1 EDK39649.2 - 0.0015 18.2 0.0 0.0032 17.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 EDK39649.2 - 0.0026 17.6 0.1 0.17 11.7 0.0 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit NB-ARC PF00931.17 EDK39649.2 - 0.0026 16.6 0.0 0.025 13.4 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA_28 PF13521.1 EDK39649.2 - 0.0071 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EDK39649.2 - 0.0083 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.9 EDK39649.2 - 0.0088 15.9 0.0 0.05 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_3 PF07726.6 EDK39649.2 - 0.02 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EDK39649.2 - 0.021 14.4 0.0 0.27 10.9 0.0 2.3 1 1 0 2 2 2 0 DNA polymerase III, delta subunit NACHT PF05729.7 EDK39649.2 - 0.025 14.2 0.0 0.066 12.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.16 EDK39649.2 - 0.034 13.2 0.1 0.088 11.9 0.1 1.7 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 EDK39649.2 - 0.038 14.1 0.0 0.095 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SKI PF01202.17 EDK39649.2 - 0.04 13.8 0.0 0.81 9.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase ABC_tran PF00005.22 EDK39649.2 - 0.051 13.8 0.0 0.14 12.4 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 EDK39649.2 - 0.052 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 EDK39649.2 - 0.06 12.8 1.3 3.9 6.9 0.0 2.7 2 1 1 3 3 3 0 DEAD/DEAH box helicase AAA_10 PF12846.2 EDK39649.2 - 0.067 12.6 0.0 3.9 6.8 0.0 3.0 2 2 1 3 3 3 0 AAA-like domain TIP49 PF06068.8 EDK39649.2 - 0.071 11.8 0.0 0.14 10.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus NTPase_1 PF03266.10 EDK39649.2 - 0.11 12.2 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.1 EDK39649.2 - 0.17 11.2 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain LIM_bind PF01803.11 EDK39650.2 - 4.5e-25 88.1 0.0 1.2e-23 83.4 0.0 2.5 1 1 0 1 1 1 1 LIM-domain binding protein PAPA-1 PF04795.7 EDK39652.2 - 5.7e-14 52.5 10.6 5.7e-14 52.5 7.3 2.8 2 1 1 3 3 3 1 PAPA-1-like conserved region Neugrin PF06413.6 EDK39654.2 - 8.9e-09 35.4 3.8 1.7e-08 34.5 2.6 1.5 1 1 0 1 1 1 1 Neugrin HTH_DeoR PF08220.7 EDK39654.2 - 0.076 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain VID27 PF08553.5 EDK39655.2 - 5.6e-254 845.0 15.7 8.9e-253 841.1 10.9 1.9 1 1 0 1 1 1 1 VID27 cytoplasmic protein DUF2697 PF10906.3 EDK39656.2 - 7.9e-34 115.4 1.1 8.9e-34 115.3 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2697) RGS PF00615.14 EDK39657.2 - 6e-10 39.2 0.0 1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain bZIP_2 PF07716.10 EDK39658.2 - 2.7e-12 46.2 8.2 5.1e-12 45.4 5.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EDK39658.2 - 0.00051 19.9 11.8 0.02 14.8 3.2 2.5 1 1 1 2 2 2 2 bZIP transcription factor Herpes_BLRF2 PF05812.7 EDK39658.2 - 0.023 14.4 1.5 0.023 14.4 1.0 1.9 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein DUF4473 PF14747.1 EDK39658.2 - 0.024 14.8 1.1 0.054 13.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) TSC22 PF01166.13 EDK39658.2 - 0.057 13.3 2.7 0.14 12.0 1.8 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family Fib_alpha PF08702.5 EDK39658.2 - 0.073 13.1 4.6 0.15 12.2 3.2 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TBPIP PF07106.8 EDK39658.2 - 0.38 10.2 9.5 0.64 9.5 6.6 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 EDK39658.2 - 0.59 10.5 4.1 1.4 9.3 2.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CPSase_L_D2 PF02786.12 EDK39659.2 - 6.6e-82 273.8 0.2 1e-81 273.2 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 EDK39659.2 - 2.8e-65 219.4 0.0 4.7e-65 218.6 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 EDK39659.2 - 7.2e-36 122.6 0.0 1.8e-35 121.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 EDK39659.2 - 1.9e-29 101.7 0.0 4.3e-29 100.6 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 EDK39659.2 - 2.4e-25 89.5 0.0 5.2e-25 88.4 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.17 EDK39659.2 - 4e-18 64.8 4.4 4e-18 64.8 3.1 2.5 3 0 0 3 3 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 EDK39659.2 - 1.1e-17 63.8 0.0 8.6e-17 60.8 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 EDK39659.2 - 7.1e-15 55.2 0.1 1.3e-14 54.3 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 EDK39659.2 - 3.3e-11 42.6 2.2 0.00017 21.1 0.5 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 EDK39659.2 - 2.5e-07 30.3 0.0 6.1e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 EDK39659.2 - 8.9e-06 25.1 0.0 1.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 EDK39659.2 - 1e-05 25.1 0.0 0.0002 20.9 0.0 2.5 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 EDK39659.2 - 0.00049 20.0 0.1 0.0021 17.9 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 EDK39659.2 - 0.00049 19.5 0.6 0.54 9.5 0.1 2.4 2 0 0 2 2 2 2 HlyD family secretion protein DUF2118 PF09891.4 EDK39659.2 - 0.00071 19.3 0.0 0.21 11.3 0.4 3.2 3 0 0 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2118) HlyD_3 PF13437.1 EDK39659.2 - 0.0069 16.7 0.4 0.25 11.6 0.2 2.8 1 1 1 2 2 2 1 HlyD family secretion protein GCV_H PF01597.14 EDK39659.2 - 0.011 15.4 1.5 0.073 12.7 0.4 2.6 1 1 1 2 2 2 0 Glycine cleavage H-protein PYNP_C PF07831.8 EDK39659.2 - 0.026 13.9 4.9 0.58 9.6 0.1 3.4 2 1 1 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain RnfC_N PF13375.1 EDK39659.2 - 0.14 11.8 4.3 0.21 11.3 0.6 2.9 3 1 1 4 4 3 0 RnfC Barrel sandwich hybrid domain DASH_Duo1 PF08651.5 EDK39660.1 - 9.7e-20 69.9 3.9 9.7e-20 69.9 2.7 1.7 1 1 1 2 2 2 1 DASH complex subunit Duo1 eIF3_N PF09440.5 EDK39660.1 - 0.0039 17.3 2.1 0.0047 17.0 0.9 1.4 1 1 0 1 1 1 1 eIF3 subunit 6 N terminal domain Tropomyosin_1 PF12718.2 EDK39660.1 - 0.011 15.5 9.5 0.014 15.2 6.6 1.1 1 0 0 1 1 1 0 Tropomyosin like DUF484 PF04340.7 EDK39660.1 - 0.093 12.1 3.5 0.14 11.5 2.4 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF484 Enkurin PF13864.1 EDK39660.1 - 0.095 12.9 2.7 5.7 7.2 0.6 2.5 2 0 0 2 2 2 0 Calmodulin-binding bZIP_2 PF07716.10 EDK39660.1 - 0.1 12.4 7.3 3.4 7.5 3.6 2.4 2 0 0 2 2 2 0 Basic region leucine zipper DUF4391 PF14335.1 EDK39660.1 - 0.11 11.8 2.8 0.14 11.5 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Nnf1 PF03980.9 EDK39660.1 - 0.13 12.2 8.1 0.68 9.9 1.6 2.4 3 0 0 3 3 2 0 Nnf1 DUF4561 PF15120.1 EDK39660.1 - 0.14 11.6 0.5 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4561) DASH_Dad2 PF08654.5 EDK39660.1 - 0.17 11.9 6.1 0.11 12.4 2.9 1.6 1 1 1 2 2 2 0 DASH complex subunit Dad2 DivIC PF04977.10 EDK39660.1 - 0.18 11.3 4.9 0.73 9.3 0.8 2.3 2 0 0 2 2 2 0 Septum formation initiator Syntaxin-6_N PF09177.6 EDK39660.1 - 0.19 12.1 8.1 0.28 11.6 3.7 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FadA PF09403.5 EDK39660.1 - 0.31 11.0 4.1 3.3 7.7 1.3 2.1 2 0 0 2 2 2 0 Adhesion protein FadA NYD-SP28_assoc PF14775.1 EDK39660.1 - 0.33 10.6 3.7 0.47 10.1 1.1 2.1 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF3782 PF12644.2 EDK39660.1 - 0.38 10.5 0.1 0.38 10.5 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3782) Hemerythrin PF01814.18 EDK39660.1 - 0.44 10.7 3.4 8.9 6.4 2.3 2.1 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain GAS PF13851.1 EDK39660.1 - 0.58 9.3 8.8 0.58 9.3 2.8 2.1 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.4 EDK39660.1 - 0.73 10.0 4.7 1.6 8.9 0.6 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cortex-I_coil PF09304.5 EDK39660.1 - 0.86 9.6 8.3 1.3 9.1 2.4 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil IncA PF04156.9 EDK39660.1 - 1.1 8.7 11.2 3 7.3 4.0 2.0 1 1 1 2 2 2 0 IncA protein TMF_DNA_bd PF12329.3 EDK39660.1 - 1.2 8.9 10.4 0.73 9.6 2.6 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.3 EDK39660.1 - 2.4 8.0 10.6 4.8 7.0 1.9 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Mnd1 PF03962.10 EDK39660.1 - 2.5 7.7 9.2 1.7 8.3 2.1 2.0 1 1 1 2 2 2 0 Mnd1 family Med31 PF05669.7 EDK39661.1 - 2.6e-40 136.3 4.7 3.1e-40 136.0 3.2 1.0 1 0 0 1 1 1 1 SOH1 Scs3p PF10261.4 EDK39662.2 - 1.6e-76 256.4 14.9 2e-76 256.1 10.3 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM DUF1129 PF06570.6 EDK39662.2 - 0.0025 17.1 1.6 0.0025 17.1 1.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1129) He_PIG PF05345.7 EDK39663.2 - 1.1e-14 54.1 17.3 1.5e-08 34.5 1.2 4.9 6 0 0 6 6 6 3 Putative Ig domain Mid2 PF04478.7 EDK39663.2 - 1e-05 25.0 1.8 6.3e-05 22.4 0.1 2.8 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor TMEM154 PF15102.1 EDK39663.2 - 1.1e-05 25.1 0.1 2.8e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family Herpes_gE PF02480.11 EDK39663.2 - 1.6e-05 23.3 0.1 2.7e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E SKG6 PF08693.5 EDK39663.2 - 0.00018 20.7 0.9 0.00063 19.0 0.6 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF1517 PF07466.6 EDK39663.2 - 0.00022 20.3 0.3 0.00065 18.7 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1517) FAM163 PF15069.1 EDK39663.2 - 0.0011 19.5 0.4 0.01 16.3 0.0 2.5 2 0 0 2 2 2 1 FAM163 family DUF4448 PF14610.1 EDK39663.2 - 0.002 17.6 0.0 0.0053 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) EphA2_TM PF14575.1 EDK39663.2 - 0.18 12.2 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain 4HBT PF03061.17 EDK39664.2 - 0.00081 19.4 1.6 1 9.5 0.0 3.6 3 1 0 3 3 3 2 Thioesterase superfamily Transket_pyr PF02779.19 EDK39665.1 - 6.3e-45 152.8 0.0 1e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 EDK39665.1 - 2.2e-35 121.2 0.1 4.6e-35 120.2 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Acatn PF13000.2 EDK39666.2 - 2.4e-161 537.9 19.1 2.9e-158 527.8 13.3 2.1 1 1 0 1 1 1 1 Acetyl-coenzyme A transporter 1 PQ-loop PF04193.9 EDK39667.2 - 4e-32 109.5 16.4 3.2e-17 61.8 1.1 3.0 3 0 0 3 3 3 2 PQ loop repeat ubiquitin PF00240.18 EDK39668.1 - 2.2e-05 23.7 0.2 2.8e-05 23.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 EDK39668.1 - 0.0014 18.8 0.2 0.0064 16.7 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Metallophos PF00149.23 EDK39669.2 - 2.5e-42 144.5 1.2 3.2e-42 144.1 0.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Aminotran_3 PF00202.16 EDK39670.2 - 2.5e-101 338.9 0.4 3.1e-101 338.6 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EDK39670.2 - 0.00064 18.7 0.0 0.00091 18.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cation_efflux PF01545.16 EDK39671.2 - 1.4e-18 67.0 9.3 1.9e-18 66.5 6.4 1.1 1 0 0 1 1 1 1 Cation efflux family DUF3040 PF11239.3 EDK39671.2 - 0.068 13.2 0.1 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Med12 PF09497.5 EDK39672.2 - 2e-26 91.7 0.2 5.6e-26 90.3 0.1 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Myosin_head PF00063.16 EDK39673.2 - 6.9e-212 705.2 6.6 1.1e-211 704.6 4.6 1.3 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 EDK39673.2 - 1.6e-40 138.5 0.0 3.2e-40 137.5 0.0 1.5 1 0 0 1 1 1 1 Myosin tail SH3_1 PF00018.23 EDK39673.2 - 3.9e-07 29.3 0.1 7.6e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK39673.2 - 6.4e-06 25.6 0.0 1.7e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.7 EDK39673.2 - 4.6e-05 22.8 0.2 0.14 11.4 0.0 2.4 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain AAA_17 PF13207.1 EDK39673.2 - 0.0025 18.6 0.0 0.02 15.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain SH3_2 PF07653.12 EDK39673.2 - 0.0042 16.5 0.0 0.0093 15.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.1 EDK39673.2 - 0.0049 17.0 0.0 0.015 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK39673.2 - 0.012 15.5 0.0 0.053 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 EDK39673.2 - 0.024 13.7 0.0 0.065 12.3 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 EDK39673.2 - 0.12 12.0 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain IQ PF00612.22 EDK39673.2 - 2.4 8.0 7.8 1.2 8.9 2.5 2.3 1 1 1 2 2 2 0 IQ calmodulin-binding motif WD40 PF00400.27 EDK39674.2 - 2.1e-89 290.5 31.9 3.4e-14 52.1 0.2 8.4 8 1 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 EDK39674.2 - 2.6e-09 37.0 0.1 0.0013 18.4 0.0 3.5 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 EDK39674.2 - 7.2e-06 24.4 11.5 0.008 14.3 0.0 4.4 2 2 2 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EDK39674.2 - 0.00069 18.4 4.4 0.019 13.7 0.7 2.7 1 1 2 3 3 3 2 Nup133 N terminal like Gmad1 PF10647.4 EDK39674.2 - 0.031 13.6 0.4 0.2 11.0 0.0 2.3 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain DUF3312 PF11768.3 EDK39674.2 - 0.045 11.9 0.0 1.2 7.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3312) Glyco_transf_41 PF13844.1 EDK39674.2 - 0.055 11.4 0.0 0.091 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 Cytochrom_D1 PF02239.11 EDK39674.2 - 0.059 11.6 0.1 0.93 7.7 0.0 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.7 EDK39674.2 - 0.11 12.1 1.7 12 5.6 0.1 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat 7TM_GPCR_Sri PF10327.4 EDK39675.2 - 0.00076 18.5 1.6 0.43 9.4 0.1 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Sri Thioredoxin_6 PF13848.1 EDK39675.2 - 0.098 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Pkinase PF00069.20 EDK39676.2 - 2.6e-69 233.2 0.0 2.3e-68 230.1 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39676.2 - 2.6e-38 131.6 0.2 1.6e-37 128.9 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39676.2 - 4.4e-07 29.1 0.0 1.5e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK39676.2 - 0.00077 19.2 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EDK39676.2 - 0.0027 16.5 0.5 0.0066 15.3 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 RIO1 PF01163.17 EDK39676.2 - 0.01 15.2 0.8 0.026 13.8 0.3 1.8 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 EDK39676.2 - 0.073 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Img2 PF05046.9 EDK39677.1 - 4.1e-23 81.4 0.6 5.2e-23 81.0 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) zf-C2H2 PF00096.21 EDK39678.2 - 9.2e-16 57.1 40.9 3.7e-05 23.7 0.4 8.5 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK39678.2 - 1.6e-15 56.4 10.7 1.3e-08 34.6 0.2 9.2 11 0 0 11 11 11 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK39678.2 - 1.6e-05 24.8 9.9 0.0027 17.8 0.3 9.3 9 1 0 9 9 9 4 C2H2-type zinc finger zf-C2H2_6 PF13912.1 EDK39678.2 - 1.6e-05 24.5 10.8 0.15 12.0 0.4 4.8 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK39678.2 - 0.0019 18.2 0.6 0.042 13.9 0.0 6.7 6 2 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK39678.2 - 0.79 10.0 19.8 0.33 11.2 0.7 5.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type PAT1 PF09770.4 EDK39680.2 - 2.1e-228 760.6 42.5 4.2e-227 756.2 29.5 1.9 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Chorismate_bind PF00425.13 EDK39681.2 - 1.3e-75 254.1 0.0 2.1e-75 253.4 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 EDK39681.2 - 6.5e-29 100.7 0.0 9.6e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 EDK39681.2 - 1.3e-17 64.1 0.0 2.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 EDK39681.2 - 1.6e-05 24.4 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 F-box-like PF12937.2 EDK39682.2 - 1.7e-06 27.6 0.7 1.7e-06 27.6 0.5 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 EDK39682.2 - 0.014 15.0 0.2 0.041 13.5 0.0 1.9 2 0 0 2 2 2 0 F-box domain DUF2146 PF10220.4 EDK39682.2 - 0.065 11.2 1.2 0.25 9.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2146) COX7a PF02238.10 EDK39683.1 - 0.0023 17.6 0.2 0.003 17.2 0.1 1.3 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIIa zf-RING_2 PF13639.1 EDK39684.2 - 1.3e-07 31.2 12.9 1.3e-07 31.2 9.0 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 EDK39684.2 - 2.1e-07 30.4 12.5 4.7e-07 29.3 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK39684.2 - 3e-06 26.8 12.6 3e-06 26.8 8.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK39684.2 - 1.5e-05 24.6 11.0 1.5e-05 24.6 7.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK39684.2 - 3.6e-05 23.5 10.2 3.6e-05 23.5 7.1 2.5 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EDK39684.2 - 4.1e-05 23.5 13.8 4.1e-05 23.5 9.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3716 PF12511.3 EDK39684.2 - 0.0024 17.4 0.6 0.0024 17.4 0.4 2.6 2 1 0 2 2 1 1 Protein of unknown function (DUF3716) zf-RING_UBOX PF13445.1 EDK39684.2 - 0.0066 16.1 4.1 0.0066 16.1 2.9 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 EDK39684.2 - 0.011 15.8 8.3 0.011 15.8 5.7 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger zf-RING_6 PF14835.1 EDK39684.2 - 0.012 15.3 4.6 0.012 15.3 3.2 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 EDK39684.2 - 3.4 7.5 10.9 0.12 12.2 3.1 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Kri1_C PF12936.2 EDK39687.2 - 2e-32 111.0 3.6 2e-32 111.0 2.5 6.1 4 2 2 6 6 6 1 KRI1-like family C-terminal Kri1 PF05178.7 EDK39687.2 - 3.1e-21 75.5 24.1 3.1e-21 75.5 16.7 6.7 3 2 3 6 6 6 1 KRI1-like family DUF1479 PF07350.7 EDK39688.2 - 3.7e-156 519.8 0.0 4.2e-156 519.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.8 EDK39688.2 - 0.00051 20.1 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) ABC_trans_N PF14510.1 EDK39689.2 - 7.5e-25 86.8 0.0 1.8e-24 85.6 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC_tran PF00005.22 EDK39689.2 - 1.4e-20 73.9 0.0 4.2e-20 72.4 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_19 PF13245.1 EDK39689.2 - 0.0076 15.9 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 EDK39689.2 - 0.016 14.5 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EDK39689.2 - 0.043 14.1 0.2 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 EDK39689.2 - 0.05 13.0 0.1 0.68 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain Rep_2 PF01719.12 EDK39689.2 - 0.074 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Plasmid replication protein DUF333 PF03891.10 EDK39690.2 - 0.11 12.2 0.2 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF333) ABC2_membrane PF01061.19 EDK39691.2 - 1.3e-33 115.9 19.5 1.6e-33 115.6 13.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter DUF3353 PF11833.3 EDK39691.2 - 0.31 10.4 2.8 0.62 9.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) 2TM PF13239.1 EDK39691.2 - 0.34 11.0 4.4 0.61 10.1 0.3 2.3 2 0 0 2 2 2 0 2TM domain DUF373 PF04123.8 EDK39691.2 - 3.8 6.4 5.4 5.3 5.9 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) ABC2_membrane PF01061.19 EDK39692.1 - 1.9e-44 151.3 24.3 1.9e-44 151.3 16.9 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 EDK39692.1 - 8.2e-20 71.5 0.0 2.2e-19 70.1 0.0 1.8 2 0 0 2 2 1 1 ABC transporter DUF258 PF03193.11 EDK39692.1 - 2.4e-06 26.8 0.0 7.3e-06 25.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 PDR_CDR PF06422.7 EDK39692.1 - 1.6e-05 24.4 1.8 0.0016 18.0 0.1 2.9 2 0 0 2 2 2 1 CDR ABC transporter AAA_25 PF13481.1 EDK39692.1 - 8.5e-05 22.0 0.1 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK39692.1 - 0.0018 18.2 0.0 0.0036 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.1 EDK39692.1 - 0.011 15.7 1.0 0.6 10.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.1 EDK39692.1 - 0.013 15.4 0.0 0.033 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 EDK39692.1 - 0.013 14.9 0.1 0.032 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.14 EDK39692.1 - 0.014 14.5 0.0 0.39 9.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.14 EDK39692.1 - 0.035 13.5 0.3 0.06 12.7 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 EDK39692.1 - 0.036 14.3 0.0 0.075 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 EDK39692.1 - 0.051 13.5 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_ATPase PF09818.4 EDK39692.1 - 0.064 11.8 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class UPF0079 PF02367.12 EDK39692.1 - 0.14 11.7 0.1 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 ABC2_membrane_3 PF12698.2 EDK39692.1 - 3.9 6.3 23.5 15 4.4 16.4 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein MFS_1 PF07690.11 EDK39693.2 - 5.2e-45 153.6 13.8 5.2e-45 153.6 9.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39693.2 - 1.1e-11 43.9 4.3 1.1e-11 43.9 2.9 3.0 2 2 1 3 3 3 1 Sugar (and other) transporter Corona_nucleoca PF00937.13 EDK39693.2 - 0.0012 17.9 0.7 0.002 17.1 0.5 1.3 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein OATP PF03137.15 EDK39693.2 - 0.008 14.2 1.6 0.51 8.3 1.1 2.8 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family CcoS PF03597.10 EDK39693.2 - 9.4 5.7 9.6 20 4.7 0.1 4.0 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Vps51 PF08700.6 EDK39694.2 - 0.0009 19.0 5.9 0.0009 19.0 4.1 2.8 2 1 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 EDK39694.2 - 0.0096 15.7 9.3 0.017 15.0 0.3 2.8 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 PH PF00169.24 EDK39694.2 - 0.019 15.1 1.5 0.041 14.1 0.2 2.2 2 0 0 2 2 2 0 PH domain Imm6 PF14434.1 EDK39694.2 - 1.7 8.3 10.4 0.74 9.5 1.5 3.6 2 1 1 3 3 3 0 Immunity protein Imm6 WD40 PF00400.27 EDK39695.2 - 1.6e-13 49.9 20.2 6.6e-05 22.6 0.0 7.2 8 0 0 8 8 8 4 WD domain, G-beta repeat LisH PF08513.6 EDK39695.2 - 2.8e-07 30.0 0.4 2.8e-07 30.0 0.3 2.2 2 0 0 2 2 2 1 LisH eIF2A PF08662.6 EDK39695.2 - 2.1e-06 27.5 0.6 0.0094 15.6 0.0 3.7 4 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A TPD52 PF04201.10 EDK39695.2 - 0.036 13.7 1.0 0.66 9.6 0.0 2.2 1 1 1 2 2 2 0 Tumour protein D52 family UPF0139 PF03669.8 EDK39696.2 - 0.0073 15.8 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) SIP1 PF04938.7 EDK39697.2 - 4.9e-14 52.2 0.3 1.6e-13 50.5 0.2 1.7 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Tfb4 PF03850.9 EDK39698.2 - 3.6e-108 361.0 1.5 4.3e-108 360.7 1.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 VWA_2 PF13519.1 EDK39698.2 - 6.3e-07 29.6 2.4 9.6e-07 29.0 1.7 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCMP_cyt_deam_1 PF00383.17 EDK39700.2 - 2.3e-22 78.5 0.0 3.1e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 EDK39700.2 - 0.0012 18.6 1.0 0.036 13.9 0.9 2.1 1 1 1 2 2 2 1 Bd3614-like deaminase MafB19-deam PF14437.1 EDK39700.2 - 0.035 13.7 0.1 0.06 12.9 0.0 1.4 1 1 0 1 1 1 0 MafB19-like deaminase XOO_2897-deam PF14440.1 EDK39700.2 - 0.045 13.4 0.1 0.17 11.5 0.0 1.8 1 1 1 2 2 2 0 Xanthomonas XOO_2897-like deaminase APOBEC_N PF08210.6 EDK39700.2 - 0.35 10.4 2.7 0.65 9.5 1.9 1.6 1 1 0 1 1 1 0 APOBEC-like N-terminal domain Pkinase PF00069.20 EDK39701.2 - 4.2e-21 75.2 0.0 8.4e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39701.2 - 7.4e-10 38.3 0.0 1.7e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.27 EDK39701.2 - 2.8e-08 33.3 1.4 0.00034 20.3 0.2 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat HEAT PF02985.17 EDK39701.2 - 0.00011 22.0 4.0 0.44 10.7 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 EDK39701.2 - 0.00072 19.7 0.0 0.052 13.8 0.0 3.4 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 EDK39701.2 - 0.36 11.3 1.3 99 3.6 0.0 4.0 3 1 1 4 4 4 0 HEAT-like repeat Cofilin_ADF PF00241.15 EDK39702.1 - 8.4e-11 41.8 0.0 8.8e-11 41.7 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Gtr1_RagA PF04670.7 EDK39702.1 - 0.15 11.1 0.2 0.17 10.9 0.1 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DSPc PF00782.15 EDK39703.2 - 4.2e-22 78.1 0.0 8.5e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.1 EDK39703.2 - 2.8e-12 46.8 0.0 2.3e-11 43.8 0.0 2.2 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.22 EDK39703.2 - 3.8e-06 26.4 0.0 8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 EDK39703.2 - 0.0056 16.1 0.3 0.01 15.3 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 EDK39703.2 - 0.012 15.7 0.1 0.04 13.9 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 EDK39703.2 - 0.054 13.7 0.2 0.16 12.2 0.1 1.8 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF3439 PF11921.3 EDK39703.2 - 0.16 11.6 4.1 1.8 8.3 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Complex1_LYR_1 PF13232.1 EDK39704.2 - 0.012 15.8 1.0 0.012 15.8 0.7 3.1 3 1 0 3 3 3 0 Complex1_LYR-like RPAP2_Rtr1 PF04181.8 EDK39705.2 - 2.7e-23 81.8 0.7 4.2e-23 81.2 0.5 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family Cofilin_ADF PF00241.15 EDK39705.2 - 0.061 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein DUF747 PF05346.6 EDK39706.2 - 1.7e-107 359.3 11.2 2.8e-107 358.6 7.7 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family COX15-CtaA PF02628.10 EDK39707.2 - 3.1e-97 325.1 8.7 3.8e-97 324.8 6.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Cytochrom_B561 PF03188.11 EDK39707.2 - 0.014 15.1 0.3 0.014 15.1 0.2 2.4 3 0 0 3 3 3 0 Eukaryotic cytochrome b561 AMP-binding PF00501.23 EDK39709.2 - 6.8e-66 222.3 0.0 8.2e-66 222.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EDK39709.2 - 4.3e-06 27.5 0.1 1.6e-05 25.7 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain YejG PF13989.1 EDK39709.2 - 0.066 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 YejG-like protein PGK PF00162.14 EDK39710.1 - 6.4e-156 518.7 1.1 7.2e-156 518.5 0.8 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Fes1 PF08609.5 EDK39711.2 - 2.2e-28 98.5 5.3 2.8e-28 98.2 1.9 2.2 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 ERCC4 PF02732.10 EDK39713.2 - 2e-10 40.6 0.8 3e-10 40.0 0.6 1.3 1 0 0 1 1 1 1 ERCC4 domain AAA-ATPase_like PF09820.4 EDK39713.2 - 0.025 13.7 0.2 0.039 13.1 0.2 1.3 1 0 0 1 1 1 0 Predicted AAA-ATPase Sec8_exocyst PF04048.9 EDK39714.2 - 3.8e-50 169.2 8.7 3.9e-50 169.1 3.8 2.7 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Sec5 PF15469.1 EDK39714.2 - 0.00045 19.9 10.2 0.0016 18.1 3.5 2.7 2 0 0 2 2 2 2 Exocyst complex component Sec5 MCPsignal PF00015.16 EDK39714.2 - 1 8.8 5.1 0.36 10.3 0.3 2.5 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ctr PF04145.10 EDK39715.2 - 1.9e-36 125.2 0.5 2.7e-36 124.7 0.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family CaMKII_AD PF08332.5 EDK39715.2 - 0.064 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association DUF3947 PF13135.1 EDK39715.2 - 0.43 10.8 3.9 0.87 9.8 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) MYT1 PF08474.6 EDK39715.2 - 5 6.5 6.1 1.3 8.4 1.9 1.5 2 0 0 2 2 2 0 Myelin transcription factor 1 DUF4229 PF14012.1 EDK39715.2 - 8.8 6.3 9.6 0.24 11.3 2.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) zf-C2H2 PF00096.21 EDK39716.2 - 0.019 15.2 11.7 2.8 8.4 0.0 4.1 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39716.2 - 0.045 14.0 8.7 7.6 7.1 1.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 EDK39717.2 - 0.00012 22.1 10.6 0.69 10.3 0.3 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger DUF3584 PF12128.3 EDK39717.2 - 0.009 13.4 3.3 0.012 13.0 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) zf-H2C2_2 PF13465.1 EDK39717.2 - 0.014 15.6 1.3 0.014 15.6 0.9 3.5 3 1 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.7 EDK39717.2 - 0.068 13.2 2.1 0.077 13.1 0.3 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 EDK39717.2 - 0.49 10.8 15.2 9.1 6.8 1.6 4.4 3 1 0 3 3 3 0 Zinc finger, C2H2 type DUF4175 PF13779.1 EDK39717.2 - 7.5 4.1 17.1 9.2 3.8 11.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ribosomal_L15e PF00827.12 EDK39718.1 - 1.6e-89 298.5 14.5 1.8e-89 298.3 10.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 AICARFT_IMPCHas PF01808.13 EDK39719.1 - 7.8e-119 396.4 0.0 1e-118 396.0 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 EDK39719.1 - 6.9e-24 83.6 0.0 2.7e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 MGS-like domain DUF3664 PF12406.3 EDK39719.1 - 0.013 16.1 0.3 0.026 15.1 0.2 1.4 1 0 0 1 1 1 0 Surface protein DnaJ PF00226.26 EDK39720.2 - 7.3e-18 64.0 0.5 1.6e-17 62.9 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.11 EDK39720.2 - 9.3e-16 57.9 0.0 1.1e-13 51.1 0.0 2.1 1 1 1 2 2 2 2 Sec63 Brl domain Acetyltransf_1 PF00583.19 EDK39721.1 - 4.2e-18 65.1 0.0 5.9e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EDK39721.1 - 2e-10 40.7 0.0 3.2e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EDK39721.1 - 3.1e-07 30.0 0.0 5.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EDK39721.1 - 6.7e-06 26.2 0.0 9.4e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EDK39721.1 - 0.00024 20.9 0.0 0.00062 19.6 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EDK39721.1 - 0.0029 17.5 0.0 0.0039 17.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 EDK39721.1 - 0.006 15.9 0.0 0.008 15.5 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Acetyltransf_8 PF13523.1 EDK39721.1 - 0.02 14.7 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK39721.1 - 0.022 14.6 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Cyt-b5 PF00173.23 EDK39722.1 - 4.7e-13 48.7 0.0 6e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TAP_C PF03943.8 EDK39723.2 - 1.1e-09 37.5 0.0 2.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.2 EDK39723.2 - 7.1e-07 28.7 2.9 1.8e-06 27.4 0.8 2.6 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) NTF2 PF02136.15 EDK39723.2 - 0.0021 18.4 0.2 0.082 13.2 0.0 2.9 2 1 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain LRR_1 PF00560.28 EDK39723.2 - 0.011 15.6 3.8 3.9 7.8 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.1 EDK39723.2 - 0.015 15.0 0.4 0.07 12.9 0.2 2.3 2 0 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.1 EDK39723.2 - 0.18 11.9 3.8 4.5 7.6 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich repeat LRR_7 PF13504.1 EDK39723.2 - 0.21 11.9 1.9 5 7.7 0.3 3.0 2 0 0 2 2 2 0 Leucine rich repeat SipA PF09052.5 EDK39723.2 - 1.4 7.2 5.7 2.3 6.4 4.0 1.3 1 0 0 1 1 1 0 Salmonella invasion protein A PIGA PF08288.7 EDK39724.2 - 4.3e-46 155.2 2.0 2.8e-45 152.5 0.6 2.4 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 EDK39724.2 - 6.3e-29 100.5 0.0 9.2e-29 100.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EDK39724.2 - 1.1e-17 64.3 0.2 1.8e-17 63.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 EDK39724.2 - 2.9e-13 50.1 0.0 5.7e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EDK39724.2 - 1.6e-12 47.8 0.0 3e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.1 EDK39724.2 - 9.9e-06 25.4 0.2 2e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 EDK39724.2 - 0.0088 16.2 0.0 0.024 14.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 CAP_GLY PF01302.20 EDK39725.2 - 5.2e-24 83.7 1.1 8.2e-24 83.1 0.8 1.3 1 0 0 1 1 1 1 CAP-Gly domain DUF4200 PF13863.1 EDK39725.2 - 0.00061 19.7 4.3 0.00061 19.7 3.0 5.3 2 1 2 5 5 5 2 Domain of unknown function (DUF4200) TACC PF05010.9 EDK39725.2 - 0.022 14.5 0.1 0.022 14.5 0.0 3.4 2 2 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) IncA PF04156.9 EDK39725.2 - 0.023 14.3 73.4 0.035 13.7 10.8 5.5 2 2 2 4 4 4 0 IncA protein Reo_sigmaC PF04582.7 EDK39725.2 - 0.48 9.5 33.6 7.6 5.6 8.3 4.5 2 1 2 4 4 4 0 Reovirus sigma C capsid protein Filament PF00038.16 EDK39725.2 - 1.2 8.5 53.6 1.1 8.7 4.7 3.8 2 1 1 3 3 3 0 Intermediate filament protein Prefoldin_3 PF13758.1 EDK39725.2 - 2 8.2 0.0 1.7 8.4 1.5 6.0 4 2 2 7 7 7 0 Prefoldin subunit APG6 PF04111.7 EDK39725.2 - 2.1 7.3 59.2 0.33 9.9 1.5 3.8 3 1 1 4 4 4 0 Autophagy protein Apg6 GAS PF13851.1 EDK39725.2 - 2.5 7.2 68.7 0.13 11.4 3.5 5.4 2 2 3 5 5 5 0 Growth-arrest specific micro-tubule binding DUF2400 PF09674.5 EDK39725.2 - 7.5 6.1 14.6 4.8 6.8 0.1 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF2400) DUF869 PF05911.6 EDK39725.2 - 7.5 4.6 58.7 0.11 10.7 7.2 3.7 2 1 2 4 4 4 0 Plant protein of unknown function (DUF869) AAA PF00004.24 EDK39727.2 - 2e-43 147.7 0.0 3.5e-43 146.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK39727.2 - 9.9e-07 28.9 0.1 2.8e-05 24.1 0.0 2.5 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 EDK39727.2 - 3.9e-06 26.6 0.2 6.9e-05 22.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EDK39727.2 - 1.3e-05 25.3 0.0 0.0031 17.6 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 EDK39727.2 - 1.5e-05 24.9 0.0 3.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 EDK39727.2 - 7.9e-05 22.3 0.1 0.00023 20.8 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EDK39727.2 - 8.6e-05 21.6 0.2 0.00017 20.6 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 EDK39727.2 - 0.00032 21.5 1.0 0.0011 19.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain UPF0079 PF02367.12 EDK39727.2 - 0.0004 20.0 0.0 0.00072 19.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 TIP49 PF06068.8 EDK39727.2 - 0.0014 17.4 0.1 0.0024 16.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 EDK39727.2 - 0.0016 17.8 0.0 0.0034 16.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.17 EDK39727.2 - 0.0028 17.8 0.0 0.0064 16.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.16 EDK39727.2 - 0.0036 16.4 0.1 0.0082 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 EDK39727.2 - 0.0057 16.5 0.0 0.016 15.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.1 EDK39727.2 - 0.0064 16.4 0.2 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 EDK39727.2 - 0.0095 15.0 0.3 0.045 12.8 0.0 2.2 3 0 0 3 3 3 1 KaiC AAA_24 PF13479.1 EDK39727.2 - 0.0099 15.4 0.4 0.018 14.5 0.3 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EDK39727.2 - 0.012 14.9 0.7 0.06 12.7 0.3 2.1 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.1 EDK39727.2 - 0.013 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EDK39727.2 - 0.013 15.7 0.3 0.087 13.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 EDK39727.2 - 0.015 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 EDK39727.2 - 0.023 13.9 0.2 0.042 13.0 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein DUF4200 PF13863.1 EDK39727.2 - 0.026 14.4 0.3 0.057 13.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Occludin_ELL PF07303.8 EDK39727.2 - 0.032 14.9 0.2 0.069 13.8 0.1 1.5 1 0 0 1 1 1 0 Occludin homology domain Sigma54_activat PF00158.21 EDK39727.2 - 0.051 13.0 0.1 0.18 11.2 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.6 EDK39727.2 - 0.069 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.12 EDK39727.2 - 0.075 11.8 0.1 0.14 11.0 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.7 EDK39727.2 - 0.11 12.2 0.1 0.24 11.0 0.0 1.7 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.1 EDK39727.2 - 0.12 11.9 0.1 0.47 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain NTP_transf_3 PF12804.2 EDK39728.2 - 1.4e-09 38.2 0.0 2.1e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 EDK39728.2 - 3.8e-08 32.4 2.0 0.00098 18.5 0.5 2.7 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 EDK39728.2 - 5.6e-06 25.8 0.0 8.8e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.1 EDK39728.2 - 0.11 12.1 5.7 2 8.0 0.5 2.7 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase DUF4588 PF15251.1 EDK39729.2 - 2.1e-24 86.8 4.9 3.1e-24 86.2 3.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Longin PF13774.1 EDK39730.2 - 4.6e-25 86.9 0.2 8e-25 86.2 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 EDK39730.2 - 5e-15 54.8 0.1 8.5e-15 54.1 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.7 EDK39730.2 - 0.00032 20.5 0.1 0.00045 20.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Gly_acyl_tr_N PF06021.6 EDK39730.2 - 0.064 12.6 0.1 0.094 12.1 0.1 1.2 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF4375 PF14300.1 EDK39730.2 - 0.076 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) Mon1 PF03164.9 EDK39731.2 - 8.6e-68 228.8 3.0 1.4e-67 228.1 2.1 1.2 1 0 0 1 1 1 1 Trafficking protein Mon1 RRF PF01765.14 EDK39732.2 - 4.6e-42 143.2 0.6 4.6e-42 143.2 0.4 1.6 1 1 1 2 2 2 1 Ribosome recycling factor STAS PF01740.16 EDK39732.2 - 0.024 14.0 0.1 0.052 12.9 0.1 1.6 1 0 0 1 1 1 0 STAS domain Ribosomal_L30_N PF08079.7 EDK39732.2 - 3.2 7.8 9.2 0.25 11.3 1.1 2.5 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain Ipi1_N PF12333.3 EDK39733.2 - 1.7e-31 108.1 1.2 1.7e-31 108.1 0.9 2.1 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation MMS19_N PF14500.1 EDK39733.2 - 0.029 13.6 1.7 3.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.1 EDK39733.2 - 0.054 13.7 0.2 0.22 11.8 0.0 2.2 2 1 0 2 2 2 0 HEAT repeats Brr6_like_C_C PF10104.4 EDK39734.2 - 8.2e-46 154.8 0.1 1.2e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain ZYG-11_interact PF05884.7 EDK39734.2 - 0.019 14.0 0.2 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 Pex24p PF06398.6 EDK39735.2 - 0.051 12.3 0.3 0.063 12.0 0.2 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Lig_chan PF00060.21 EDK39735.2 - 0.11 12.1 0.4 0.22 11.2 0.3 1.5 1 1 0 1 1 1 0 Ligand-gated ion channel Motilin_ghrelin PF04644.7 EDK39735.2 - 0.15 11.8 1.7 0.38 10.5 1.2 1.7 1 0 0 1 1 1 0 Motilin/ghrelin Sugar_tr PF00083.19 EDK39736.1 - 4.3e-64 216.7 2.9 4.8e-64 216.6 2.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39736.1 - 6e-19 67.9 3.3 8.2e-19 67.5 2.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.8 EDK39736.1 - 0.0016 16.6 3.0 0.0022 16.2 2.1 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_2 PF13347.1 EDK39736.1 - 0.2 10.0 9.8 0.015 13.7 3.1 1.8 2 1 0 2 2 2 0 MFS/sugar transport protein Zip PF02535.17 EDK39736.1 - 0.99 8.3 4.3 1.3 7.9 0.7 2.3 2 1 0 2 2 2 0 ZIP Zinc transporter Sugar_tr PF00083.19 EDK39737.1 - 3.2e-44 151.2 17.3 3.6e-44 151.0 12.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Ilm1 PF10311.4 EDK39737.1 - 0.054 12.9 2.9 0.093 12.2 2.0 1.4 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 PrgI PF12666.2 EDK39737.1 - 6.7 6.9 9.9 2 8.6 0.1 2.5 2 0 0 2 2 2 0 PrgI family protein DUF3792 PF12670.2 EDK39737.1 - 6.9 6.5 11.4 1 9.2 3.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) DUF904 PF06005.7 EDK39738.2 - 0.025 14.8 3.5 0.041 14.1 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF904) BssS PF13991.1 EDK39738.2 - 0.033 13.9 0.1 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 BssS protein family DUF2207 PF09972.4 EDK39738.2 - 0.72 8.3 6.8 30 3.0 4.7 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3981 PF13139.1 EDK39738.2 - 3 7.8 6.5 4.5 7.2 3.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) MFS_1 PF07690.11 EDK39739.2 - 2.3e-23 82.4 28.4 2.3e-23 82.4 19.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 EDK39740.2 - 2.7e-32 111.8 35.7 2.7e-32 111.8 24.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldolase_II PF00596.16 EDK39741.2 - 2.3e-43 147.9 0.2 2.8e-43 147.6 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Pkinase PF00069.20 EDK39742.2 - 1.4e-59 201.3 0.0 1.9e-59 200.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39742.2 - 2e-33 115.5 0.0 2.7e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39742.2 - 0.0087 15.0 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like zinc-ribbons_6 PF07191.7 EDK39743.2 - 0.0048 16.6 2.3 0.0048 16.6 1.6 4.6 3 2 2 5 5 5 1 zinc-ribbons DUF4407 PF14362.1 EDK39743.2 - 0.19 10.6 9.8 0.32 9.9 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) C1_1 PF00130.17 EDK39743.2 - 0.39 10.4 21.6 1.5 8.6 0.9 4.8 4 1 1 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Auto_anti-p27 PF06677.7 EDK39743.2 - 0.82 9.4 13.0 1.9 8.2 0.0 3.6 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TFIIA PF03153.8 EDK39743.2 - 1.2 8.9 33.0 0.18 11.6 18.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DZR PF12773.2 EDK39743.2 - 2 8.2 33.2 2.1e+03 -1.4 12.5 4.7 1 1 1 2 2 2 0 Double zinc ribbon DUF2318 PF10080.4 EDK39743.2 - 5.9 6.7 15.3 4.7 7.0 0.9 3.6 2 1 1 3 3 3 0 Predicted membrane protein (DUF2318) Lin-8 PF03353.10 EDK39743.2 - 6.3 5.9 18.1 12 5.0 12.6 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RRM_1 PF00076.17 EDK39744.2 - 1.7e-19 69.1 0.4 2.2e-12 46.3 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK39744.2 - 1.2e-13 50.7 1.0 1.9e-09 37.3 0.0 3.3 3 1 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK39744.2 - 6.2e-05 22.7 0.2 0.16 11.8 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sds3 PF08598.6 EDK39745.2 - 2.6e-40 138.1 0.0 2.6e-40 138.1 0.0 2.8 2 1 0 2 2 2 1 Sds3-like BRCT PF00533.21 EDK39747.2 - 2.8e-09 37.0 0.2 6.5e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EDK39747.2 - 1.3e-06 28.1 0.0 2.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain DUF3006 PF11213.3 EDK39747.2 - 0.0007 19.2 0.1 0.0007 19.2 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) CTD PF12815.2 EDK39748.1 - 0.12 12.8 7.4 0.66 10.3 5.1 2.0 1 1 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Transcrip_reg PF01709.15 EDK39749.2 - 8e-67 224.7 0.9 9.1e-67 224.5 0.7 1.0 1 0 0 1 1 1 1 Transcriptional regulator Mito_carr PF00153.22 EDK39750.2 - 9e-71 233.6 1.9 9.3e-26 89.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PT-VENN PF04829.8 EDK39750.2 - 0.015 14.8 1.9 1.5 8.4 0.1 2.6 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif Abhydrolase_3 PF07859.8 EDK39751.2 - 0.033 13.7 0.1 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK39751.2 - 0.09 12.6 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Aminotran_3 PF00202.16 EDK39752.2 - 5.9e-82 275.2 0.0 7.1e-82 274.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 EDK39752.2 - 0.0044 16.0 0.0 0.0062 15.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II TRF PF08558.5 EDK39753.2 - 5.4e-86 287.8 0.0 8e-86 287.2 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 EDK39753.2 - 6.2e-07 29.3 0.5 1.3e-06 28.3 0.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK39753.2 - 3.5e-05 23.8 0.0 8.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.27 EDK39754.2 - 3.5e-39 131.2 28.8 9.6e-07 28.4 0.7 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat PTSIIA_gutA PF03829.8 EDK39754.2 - 0.032 13.8 0.0 7.5 6.2 0.0 2.3 2 0 0 2 2 2 0 PTS system glucitol/sorbitol-specific IIA component eIF2A PF08662.6 EDK39754.2 - 0.097 12.3 0.1 0.75 9.4 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A YEATS PF03366.11 EDK39755.2 - 1.2e-25 89.0 0.0 2.1e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 YEATS family FlgM PF04316.8 EDK39755.2 - 0.093 12.6 0.0 2.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM YqeY PF09424.5 EDK39756.2 - 4e-18 65.6 3.4 5.1e-18 65.3 2.3 1.1 1 0 0 1 1 1 1 Yqey-like protein PYRIN PF02758.11 EDK39756.2 - 0.075 12.7 0.3 0.31 10.7 0.0 2.1 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain DSPc PF00782.15 EDK39757.2 - 8.6e-16 57.7 0.0 4.8e-14 52.0 0.0 2.9 3 1 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Glyco_transf_11 PF01531.11 EDK39757.2 - 0.042 12.8 0.1 1.8 7.4 0.0 2.7 3 0 0 3 3 3 0 Glycosyl transferase family 11 Y_phosphatase PF00102.22 EDK39757.2 - 0.07 12.4 0.0 0.7 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein-tyrosine phosphatase DHFR_1 PF00186.14 EDK39759.2 - 2.4e-31 108.5 0.0 2.9e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Pyridox_oxase_2 PF12766.2 EDK39761.2 - 1.7e-29 102.0 0.0 3.4e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 EDK39761.2 - 1.6e-07 31.2 0.1 3.6e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Ras PF00071.17 EDK39762.2 - 1.9e-50 170.4 0.1 2.4e-50 170.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK39762.2 - 1.4e-20 74.0 0.5 7.3e-20 71.6 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 EDK39762.2 - 5.4e-08 32.2 0.0 7.5e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK39762.2 - 7.4e-06 25.5 0.0 1.3e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK39762.2 - 3.6e-05 23.6 0.0 6.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 EDK39762.2 - 0.024 14.6 0.2 3.6 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.13 EDK39762.2 - 0.027 13.7 0.1 0.063 12.5 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B G-alpha PF00503.15 EDK39762.2 - 0.43 9.2 8.0 0.66 8.6 0.0 3.0 1 1 0 3 3 3 0 G-protein alpha subunit GST_N_2 PF13409.1 EDK39763.2 - 4.1e-25 87.5 0.1 5.8e-24 83.8 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 EDK39763.2 - 8.6e-13 47.9 0.0 2.8e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 EDK39763.2 - 1.5e-06 28.6 0.0 3.8e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 EDK39763.2 - 1.5e-05 25.0 0.1 0.11 12.7 0.0 2.8 3 0 0 3 3 3 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 EDK39763.2 - 2.8e-05 23.9 0.0 6.1e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.21 EDK39764.2 - 3.3e-05 23.9 0.5 3.3e-05 23.9 0.4 4.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39764.2 - 0.02 15.1 1.0 0.02 15.1 0.7 4.3 4 1 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.2 EDK39764.2 - 0.021 15.0 4.2 0.094 12.9 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 EDK39764.2 - 0.067 13.1 0.1 0.067 13.1 0.1 3.7 4 1 1 5 5 5 0 C2H2-type zinc finger Med15 PF09606.5 EDK39764.2 - 0.21 9.7 77.5 0.039 12.1 34.9 2.2 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal MCM PF00493.18 EDK39766.1 - 1.2e-120 402.2 0.1 1.8e-120 401.7 0.1 1.3 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 EDK39766.1 - 8.9e-07 28.2 0.0 6.1e-06 25.5 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EDK39766.1 - 0.0059 16.2 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK39766.1 - 0.0065 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain MCM_N PF14551.1 EDK39767.2 - 6.6e-20 71.8 0.0 1e-19 71.1 0.0 1.3 1 0 0 1 1 1 1 MCM N-terminal domain MCM PF00493.18 EDK39767.2 - 0.017 13.9 0.0 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family HypA PF01155.14 EDK39767.2 - 0.044 13.4 0.2 0.18 11.4 0.1 1.9 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 EDK39767.2 - 0.16 11.9 2.4 0.52 10.3 1.6 1.8 1 0 0 1 1 1 0 Zinc ribbon domain tRNA_bind PF01588.15 EDK39768.1 - 2.4e-11 43.2 0.1 3.4e-11 42.8 0.1 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain AhpC-TSA PF00578.16 EDK39769.2 - 9.3e-35 119.0 0.0 1.3e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EDK39769.2 - 1.7e-16 60.0 0.0 2.2e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 EDK39769.2 - 2.2e-12 46.4 0.0 3.9e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Fungal_trans PF04082.13 EDK39770.2 - 1.4e-19 70.0 2.1 2.6e-19 69.1 1.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39770.2 - 4.1e-09 36.1 10.2 7.3e-09 35.3 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PEGSRP PF07623.6 EDK39770.2 - 0.056 12.7 3.1 0.12 11.6 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1584) Rad51 PF08423.6 EDK39771.2 - 5.1e-140 464.6 0.0 6.4e-140 464.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 EDK39771.2 - 5.6e-12 45.4 0.0 7.6e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 EDK39771.2 - 3.5e-10 39.4 0.0 5e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.1 EDK39771.2 - 2.8e-09 37.0 0.1 7.6e-09 35.6 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain KaiC PF06745.8 EDK39771.2 - 4e-07 29.3 0.0 7.1e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 KaiC PAXNEB PF05625.6 EDK39771.2 - 0.0038 16.1 0.1 0.031 13.0 0.0 2.0 2 0 0 2 2 2 1 PAXNEB protein AAA_22 PF13401.1 EDK39771.2 - 0.013 15.6 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 EDK39771.2 - 0.062 12.1 0.1 0.13 11.0 0.0 1.5 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain HhH-GPD PF00730.20 EDK39771.2 - 0.15 12.3 0.0 0.31 11.3 0.0 1.7 1 1 1 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein Pkinase PF00069.20 EDK39772.2 - 8.8e-69 231.5 0.0 1.6e-68 230.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39772.2 - 3.2e-40 137.8 0.0 5.3e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39772.2 - 2e-09 36.8 0.0 3.6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK39772.2 - 0.00076 18.5 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK39772.2 - 0.0044 16.7 0.1 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 EDK39772.2 - 0.024 14.0 0.3 0.053 12.8 0.2 1.5 1 0 0 1 1 1 0 RIO1 family zf-NF-X1 PF01422.12 EDK39773.2 - 0.0013 18.6 9.0 0.0013 18.6 6.2 13.2 16 0 0 16 16 16 4 NF-X1 type zinc finger Fcf1 PF04900.7 EDK39774.1 - 1.3e-35 121.4 0.6 1.3e-35 121.4 0.4 1.6 2 0 0 2 2 2 1 Fcf1 Pox_Ag35 PF03286.9 EDK39774.1 - 0.075 12.5 9.0 0.12 11.8 6.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein OPT PF03169.10 EDK39775.2 - 1.1e-191 638.5 59.0 1.3e-191 638.3 40.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Iron_permease PF04120.7 EDK39775.2 - 0.059 12.9 0.6 0.16 11.5 0.4 1.7 1 0 0 1 1 1 0 Low affinity iron permease GrpE PF01025.14 EDK39776.1 - 4.7e-54 182.3 7.1 6.9e-54 181.8 4.9 1.3 1 1 0 1 1 1 1 GrpE IncA PF04156.9 EDK39776.1 - 0.0024 17.4 7.3 0.0035 16.9 5.1 1.2 1 0 0 1 1 1 1 IncA protein DUF812 PF05667.6 EDK39776.1 - 0.013 14.0 7.7 0.016 13.7 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GAS PF13851.1 EDK39776.1 - 0.066 12.4 13.2 0.11 11.7 9.2 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding OmpH PF03938.9 EDK39776.1 - 0.12 12.2 12.0 0.19 11.6 8.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Mod_r PF07200.8 EDK39776.1 - 0.24 11.2 12.1 0.21 11.5 6.6 1.9 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TMPIT PF07851.8 EDK39776.1 - 0.42 9.6 3.3 0.53 9.3 2.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein Med9 PF07544.8 EDK39776.1 - 0.52 10.0 5.4 1.1 9.0 2.6 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Exonuc_VII_L PF02601.10 EDK39776.1 - 0.67 9.0 6.2 0.83 8.7 4.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.14 EDK39776.1 - 0.94 7.2 4.8 1.1 7.0 3.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF740 PF05340.7 EDK39776.1 - 1.3 7.2 7.8 1.6 7.0 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Adeno_PIX PF03955.9 EDK39776.1 - 1.4 9.5 4.1 1.3 9.5 0.5 2.2 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) DUF2205 PF10224.4 EDK39776.1 - 3 7.4 10.6 0.067 12.7 0.8 2.2 1 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Iso_dh PF00180.15 EDK39777.1 - 1.6e-33 116.1 0.0 1.9e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.15 EDK39778.2 - 1e-59 202.2 0.0 1.3e-59 201.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pkinase PF00069.20 EDK39779.2 - 3.7e-41 141.0 0.0 5.8e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39779.2 - 2.4e-23 82.5 0.0 4.6e-23 81.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK39779.2 - 0.12 12.0 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 EDK39779.2 - 0.19 10.5 0.0 0.42 9.3 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Nol1_Nop2_Fmu PF01189.12 EDK39780.2 - 4.6e-20 72.1 0.0 1.1e-19 70.9 0.0 1.6 2 0 0 2 2 2 1 NOL1/NOP2/sun family FtsJ PF01728.14 EDK39780.2 - 0.035 14.0 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 FtsJ-like methyltransferase NusB PF01029.13 EDK39780.2 - 0.11 12.4 0.4 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 NusB family Hist_deacetyl PF00850.14 EDK39781.2 - 8.8e-95 317.5 0.0 1.3e-94 316.9 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 EDK39781.2 - 1.9e-53 180.5 0.3 3.9e-53 179.5 0.2 1.5 1 0 0 1 1 1 1 Arb2 domain GldM_N PF12081.3 EDK39781.2 - 0.059 12.8 0.6 0.34 10.4 0.1 2.3 3 0 0 3 3 3 0 GldM N-terminal domain His_Phos_1 PF00300.17 EDK39782.2 - 9.4e-19 68.0 0.1 1.7e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) WD40 PF00400.27 EDK39783.2 - 0.022 14.6 0.6 3.2 7.7 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Ycf15 PF10705.4 EDK39783.2 - 0.09 12.8 2.0 0.098 12.7 0.0 2.0 2 0 0 2 2 2 0 Chloroplast protein precursor Ycf15 putative DUF3812 PF12757.2 EDK39783.2 - 0.25 11.3 9.7 0.41 10.6 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3812) DUF788 PF05620.6 EDK39783.2 - 2.1 8.1 6.1 3.6 7.4 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF788) BLVR PF06375.6 EDK39783.2 - 3.8 7.3 14.4 1.2 8.9 8.0 1.6 2 0 0 2 2 2 0 Bovine leukaemia virus receptor (BLVR) Peptidase_S49_N PF08496.5 EDK39783.2 - 7.3 6.3 9.6 12 5.6 6.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Myb_DNA-binding PF00249.26 EDK39784.2 - 2.2e-08 33.9 0.0 5.9e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF3698 PF12479.3 EDK39784.2 - 2 8.5 5.6 4.8 7.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3698) PIG-H PF10181.4 EDK39785.2 - 8.4e-26 89.3 0.1 1.6e-25 88.5 0.1 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component RhoGAP PF00620.22 EDK39786.2 - 3.8e-34 117.4 0.3 1.1e-33 116.0 0.2 1.9 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 EDK39786.2 - 3.4e-31 107.0 50.1 3.5e-11 42.9 4.6 4.5 4 0 0 4 4 4 4 LIM domain DUF2793 PF10983.3 EDK39786.2 - 0.19 11.5 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2793) Auto_anti-p27 PF06677.7 EDK39786.2 - 0.21 11.3 4.0 0.97 9.2 0.8 3.1 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) BolA PF01722.13 EDK39787.1 - 3.2e-21 75.0 0.0 3.9e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein MFS_1 PF07690.11 EDK39788.2 - 7.9e-25 87.2 29.5 7.9e-25 87.2 20.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 EDK39788.2 - 0.016 15.2 5.5 1.4 9.0 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) RNA_pol_Rpb6 PF01192.17 EDK39788.2 - 0.02 14.6 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb6 FA_desaturase PF00487.19 EDK39788.2 - 0.25 10.7 0.0 0.25 10.7 0.0 2.5 1 1 1 2 2 2 0 Fatty acid desaturase NIF3 PF01784.13 EDK39789.2 - 6.6e-55 186.3 0.0 7.7e-55 186.0 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Phosphodiest PF01663.17 EDK39790.2 - 3.9e-85 286.3 1.8 3.9e-85 286.3 1.2 1.6 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 EDK39790.2 - 0.0036 16.5 0.1 0.13 11.4 0.0 2.3 2 0 0 2 2 2 2 Sulfatase zf-Nse PF11789.3 EDK39791.2 - 1.4e-16 59.7 0.0 2.3e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 EDK39791.2 - 0.0021 17.7 0.2 0.0085 15.7 0.0 2.1 2 0 0 2 2 2 1 RING-type zinc-finger RMF PF04957.7 EDK39791.2 - 0.035 13.7 1.4 0.044 13.4 0.0 1.8 2 0 0 2 2 2 0 Ribosome modulation factor zf-RING_2 PF13639.1 EDK39791.2 - 0.049 13.4 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.2 EDK39791.2 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 EDK39791.2 - 0.13 12.3 0.3 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_2_C PF02836.12 EDK39791.2 - 0.25 10.2 3.5 0.41 9.4 2.4 1.4 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Methyltransf_11 PF08241.7 EDK39792.2 - 1.2e-22 80.2 0.0 2.3e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK39792.2 - 2.1e-18 66.5 0.0 2.9e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK39792.2 - 1.8e-17 63.3 0.0 2.2e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK39792.2 - 2.8e-11 43.6 0.0 5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK39792.2 - 3.3e-11 43.7 0.0 7.3e-11 42.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK39792.2 - 1.7e-10 41.2 0.0 2.8e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK39792.2 - 4.1e-09 35.8 0.0 6.1e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 EDK39792.2 - 7.2e-08 32.4 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 EDK39792.2 - 7.1e-06 24.6 0.1 4.7e-05 21.9 0.0 1.8 1 1 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 EDK39792.2 - 0.00018 20.9 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.15 EDK39792.2 - 0.00028 19.9 0.0 0.00046 19.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.7 EDK39792.2 - 0.0013 18.0 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PCMT PF01135.14 EDK39792.2 - 0.0021 17.6 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.6 EDK39792.2 - 0.0021 16.7 0.0 0.0052 15.5 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) DREV PF05219.7 EDK39792.2 - 0.0025 16.7 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.9 EDK39792.2 - 0.075 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DOT1 PF08123.8 EDK39792.2 - 0.088 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_31 PF13847.1 EDK39793.1 - 2.3e-25 88.9 0.0 2.7e-25 88.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK39793.1 - 3.3e-22 78.7 0.0 6.8e-22 77.7 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK39793.1 - 4.6e-19 68.4 0.0 8.8e-19 67.5 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 EDK39793.1 - 8e-16 58.6 0.0 1.6e-15 57.6 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK39793.1 - 2.2e-15 56.8 0.0 5e-15 55.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK39793.1 - 7e-13 48.6 0.0 8.3e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK39793.1 - 1.1e-12 48.2 0.0 2.9e-12 46.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK39793.1 - 3.2e-07 30.3 0.0 9e-07 28.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK39793.1 - 1e-06 28.2 0.0 1.5e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EDK39793.1 - 2.6e-06 27.1 0.0 3.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.7 EDK39793.1 - 7.1e-06 25.5 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.8 EDK39793.1 - 2.7e-05 23.4 0.0 5.7e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.12 EDK39793.1 - 0.00011 21.2 0.3 0.00074 18.6 0.0 2.3 2 1 1 3 3 3 1 Putative methyltransferase Methyltransf_9 PF08003.6 EDK39793.1 - 0.00013 20.8 0.0 0.00018 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_8 PF05148.10 EDK39793.1 - 0.00019 21.1 0.0 0.00073 19.2 0.0 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.15 EDK39793.1 - 0.0003 19.9 0.2 0.00063 18.9 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EDK39793.1 - 0.0024 17.5 0.1 0.0051 16.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.13 EDK39793.1 - 0.02 14.1 0.1 0.22 10.7 0.0 2.1 2 0 0 2 2 2 0 O-methyltransferase FmrO PF07091.6 EDK39793.1 - 0.026 13.5 0.0 0.042 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) UPF0020 PF01170.13 EDK39793.1 - 0.03 13.8 0.1 0.07 12.7 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Rsm22 PF09243.5 EDK39793.1 - 0.094 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 MFS_1 PF07690.11 EDK39794.2 - 7.5e-38 130.1 32.9 7.5e-38 130.1 22.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 EDK39794.2 - 0.0079 14.2 6.3 0.3 9.0 4.4 2.5 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Zn_clus PF00172.13 EDK39795.2 - 2.5e-09 36.8 12.6 2.5e-09 36.8 8.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2614 PF11023.3 EDK39795.2 - 0.49 10.2 6.6 3.8 7.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) GCR1_C PF12550.3 EDK39796.2 - 0.0019 18.0 0.4 0.0047 16.7 0.2 1.7 1 1 0 1 1 1 1 Transcriptional activator of glycolytic enzymes ERM PF00769.14 EDK39796.2 - 1.3 8.4 8.3 0.085 12.3 1.5 2.0 2 1 0 2 2 2 0 Ezrin/radixin/moesin family ELFV_dehydrog PF00208.16 EDK39797.1 - 1.3e-85 286.8 5.4 1.6e-85 286.6 3.7 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 EDK39797.1 - 5.7e-47 158.5 0.0 9.9e-47 157.7 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.1 EDK39797.1 - 0.13 12.5 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Tim54 PF11711.3 EDK39798.2 - 7.1e-150 498.8 2.1 9.7e-150 498.3 1.4 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 cobW PF02492.14 EDK39799.2 - 1.8e-41 141.5 0.8 2.4e-41 141.1 0.6 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 EDK39799.2 - 4.5e-07 29.4 0.0 1.7e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_29 PF13555.1 EDK39799.2 - 0.002 17.6 0.0 0.0054 16.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 EDK39799.2 - 0.0022 18.2 0.4 0.0061 16.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 EDK39799.2 - 0.003 17.4 0.0 0.0073 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 EDK39799.2 - 0.0079 16.5 0.7 0.017 15.4 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK39799.2 - 0.012 15.5 0.1 0.036 14.0 0.0 1.7 2 1 1 3 3 3 0 AAA ATPase domain Arch_ATPase PF01637.13 EDK39799.2 - 0.044 13.4 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase GTP_EFTU PF00009.22 EDK39799.2 - 0.044 13.2 0.1 4 6.8 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK39799.2 - 0.051 13.5 0.3 0.12 12.3 0.2 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 EDK39799.2 - 0.053 13.6 0.2 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 EDK39799.2 - 0.061 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 EDK39799.2 - 0.087 13.1 0.3 0.25 11.6 0.1 1.8 2 0 0 2 2 2 0 ABC transporter Glyco_transf_22 PF03901.12 EDK39800.2 - 2.8e-35 122.1 21.1 4.3e-35 121.5 14.6 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF3341 PF11821.3 EDK39800.2 - 1.1 8.7 4.8 56 3.1 0.0 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3341) Sfi1 PF08457.5 EDK39801.2 - 2.2e-39 135.3 72.2 2.2e-39 135.3 50.1 2.2 1 1 1 2 2 2 2 Sfi1 spindle body protein Pkinase PF00069.20 EDK39802.2 - 7.2e-68 228.5 0.0 1.3e-67 227.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK39802.2 - 4e-44 150.6 0.0 8.8e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK39802.2 - 1.6e-08 33.8 0.0 1.5e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_1 PF00536.25 EDK39802.2 - 0.0013 18.8 0.0 0.0081 16.3 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Ribosomal_L21p PF00829.16 EDK39803.2 - 3e-05 24.0 0.0 4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein UPF0640 PF15114.1 EDK39803.2 - 0.14 11.6 0.5 0.63 9.5 0.2 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0640 SAPS PF04499.10 EDK39804.2 - 1.3e-181 604.4 3.9 1.3e-181 604.4 2.7 2.4 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein Nha1_C PF08619.5 EDK39804.2 - 0.00047 19.5 7.7 0.00047 19.5 5.3 2.5 3 1 0 3 3 3 1 Alkali metal cation/H+ antiporter Nha1 C terminus TAF4 PF05236.9 EDK39804.2 - 0.0033 16.7 6.1 0.0062 15.8 4.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family FLO_LFY PF01698.11 EDK39804.2 - 8 5.1 10.5 0.19 10.5 2.5 1.7 2 0 0 2 2 2 0 Floricaula / Leafy protein CPSF100_C PF13299.1 EDK39804.2 - 9.3 6.4 9.1 6.7 6.8 3.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1687 PF07955.6 EDK39805.2 - 7.4e-24 84.2 0.0 1e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) GATase_4 PF13230.1 EDK39806.2 - 2.9e-17 62.2 0.0 6.8e-17 61.0 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 EDK39806.2 - 2.2e-12 47.0 0.0 3.9e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 EDK39806.2 - 4.2e-09 35.5 0.0 1.7e-07 30.2 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 EDK39806.2 - 0.053 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase domain Isochorismatase PF00857.15 EDK39807.1 - 5e-37 127.5 0.1 5.5e-37 127.3 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family PyrI_C PF02748.10 EDK39808.1 - 0.0095 15.3 0.3 0.026 13.9 0.2 1.8 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain NPDC1 PF06809.6 EDK39808.1 - 0.08 11.7 0.3 0.11 11.2 0.2 1.2 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) DUF2881 PF11087.3 EDK39808.1 - 0.29 10.6 3.2 3.8 7.0 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2881) Synaphin PF05835.7 EDK39809.2 - 0.22 11.6 4.1 0.3 11.2 2.8 1.2 1 0 0 1 1 1 0 Synaphin protein DUF904 PF06005.7 EDK39809.2 - 0.69 10.2 10.8 10 6.4 7.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF904) PTPLA PF04387.9 EDK39810.2 - 2e-42 144.4 10.5 2e-42 144.4 7.3 1.8 2 1 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA PTPLA PF04387.9 EDK39811.1 - 4.7e-56 188.7 8.8 7.1e-56 188.1 6.1 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ChAPs PF09295.5 EDK39812.2 - 1.2e-25 90.0 0.0 5.3e-21 74.8 0.0 2.4 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) Apc3 PF12895.2 EDK39812.2 - 0.00014 21.8 0.0 0.00048 20.2 0.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 EDK39812.2 - 0.0037 16.8 0.0 0.01 15.4 0.0 1.7 1 0 0 1 1 1 1 TPR repeat TPR_19 PF14559.1 EDK39812.2 - 0.035 14.4 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 EDK39812.2 - 0.17 12.5 0.0 0.36 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat LRR_4 PF12799.2 EDK39813.2 - 5.6e-51 169.4 85.1 4.1e-08 32.6 3.4 11.9 6 3 7 13 13 13 11 Leucine Rich repeats (2 copies) PP2C PF00481.16 EDK39813.2 - 5.9e-46 156.9 0.0 9.9e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.1 EDK39813.2 - 1.4e-45 152.8 70.0 1.2e-10 40.9 5.1 8.8 5 2 3 8 8 8 7 Leucine rich repeat Guanylate_cyc PF00211.15 EDK39813.2 - 1.6e-28 99.3 0.0 3.2e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 EDK39813.2 - 1.6e-24 82.1 74.4 0.0067 16.3 0.2 19.2 20 0 0 20 20 20 9 Leucine Rich Repeat RA PF00788.18 EDK39813.2 - 3.3e-12 46.7 0.0 8.7e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain LRR_7 PF13504.1 EDK39813.2 - 5.5e-07 28.7 73.1 0.61 10.5 0.0 17.5 19 0 0 19 19 19 4 Leucine rich repeat LRR_6 PF13516.1 EDK39813.2 - 0.0021 17.9 67.9 1 9.6 0.1 17.2 17 2 2 19 19 19 2 Leucine Rich repeat LRR_5 PF13306.1 EDK39813.2 - 0.014 15.0 12.1 0.29 10.8 0.2 4.8 3 2 1 4 4 4 0 Leucine rich repeats (6 copies) LRR_9 PF14580.1 EDK39813.2 - 0.2 11.1 14.5 0.8 9.2 1.1 4.1 2 1 2 4 4 4 0 Leucine-rich repeat Ad_cyc_g-alpha PF08509.6 EDK39814.2 - 4.3e-06 25.9 1.4 1.2e-05 24.5 1.0 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain Pneumo_att_G PF05539.6 EDK39814.2 - 1.2 8.3 7.6 1.8 7.8 5.3 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Golgin_A5 PF09787.4 EDK39814.2 - 2.8 6.3 8.4 4.1 5.8 5.8 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DEAD PF00270.24 EDK39816.2 - 1.4e-43 148.2 0.8 3.2e-43 147.1 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39816.2 - 1.2e-24 85.9 0.0 4.2e-24 84.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF572 PF04502.8 EDK39816.2 - 5.6 6.0 45.2 0.93 8.6 10.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) SYS1 PF09801.4 EDK39817.2 - 2.9e-51 173.2 16.4 3.3e-51 173.0 11.3 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Glyco_hydro_3 PF00933.16 EDK39818.2 - 4.2e-81 272.2 0.0 6.1e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 EDK39818.2 - 1e-67 228.0 0.0 4.8e-67 225.7 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 EDK39818.2 - 4.1e-23 81.1 0.6 9.6e-23 79.9 0.1 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.7 EDK39818.2 - 1.1e-14 54.2 0.1 2.4e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 PA14 domain Aldolase_II PF00596.16 EDK39819.1 - 6.3e-48 162.8 1.0 8.1e-48 162.4 0.7 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3148 PF11347.3 EDK39819.1 - 0.15 11.6 0.0 0.58 9.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3148) TetR_N PF00440.18 EDK39819.1 - 1.9 8.2 4.7 4.6 6.9 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family AA_permease PF00324.16 EDK39820.2 - 5.9e-109 364.5 45.3 7.4e-109 364.2 31.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK39820.2 - 4.6e-25 88.0 47.2 6.3e-25 87.5 32.7 1.0 1 0 0 1 1 1 1 Amino acid permease FMN_dh PF01070.13 EDK39821.2 - 3.9e-62 210.1 0.4 1.5e-61 208.2 0.3 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 EDK39821.2 - 1.1e-09 37.7 0.0 1.9e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 EDK39821.2 - 6.3e-06 25.3 0.3 0.00024 20.0 0.1 2.2 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 EDK39821.2 - 0.0016 17.6 0.5 0.0044 16.2 0.3 1.8 1 1 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.16 EDK39821.2 - 0.014 14.7 0.3 1.1 8.4 0.0 2.5 2 1 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.9 EDK39821.2 - 0.038 13.0 0.0 1.6 7.7 0.0 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG FMN_dh PF01070.13 EDK39822.2 - 1.2e-24 86.8 0.0 1.7e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EDK39822.2 - 5.4e-20 70.9 0.0 1.3e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Aminotran_3 PF00202.16 EDK39823.1 - 3.3e-61 207.0 0.0 4.2e-61 206.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Ribonuc_L-PSP PF01042.16 EDK39824.2 - 1.1e-24 86.5 0.1 1.3e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP SEA PF01390.15 EDK39824.2 - 0.037 13.7 0.2 5.4 6.7 0.0 2.1 2 0 0 2 2 2 0 SEA domain MoCF_biosynth PF00994.19 EDK39824.2 - 0.06 12.7 0.0 0.067 12.6 0.0 1.1 1 0 0 1 1 1 0 Probable molybdopterin binding domain DUF1904 PF08921.6 EDK39824.2 - 0.13 12.3 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) Epimerase PF01370.16 EDK39825.1 - 1.9e-19 70.0 0.0 2.6e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK39825.1 - 9.5e-16 57.3 0.0 1.4e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EDK39825.1 - 2.9e-10 39.4 0.1 1.3e-08 34.1 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EDK39825.1 - 6.4e-07 29.5 0.0 1.9e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EDK39825.1 - 2.5e-06 27.5 0.0 4.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 EDK39825.1 - 0.00074 18.5 0.2 0.0013 17.6 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 EDK39825.1 - 0.0054 16.4 0.0 0.009 15.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 EDK39825.1 - 0.026 13.7 0.0 0.064 12.4 0.0 1.7 2 0 0 2 2 2 0 NmrA-like family Zeta_toxin PF06414.7 EDK39825.1 - 0.044 12.8 0.0 0.075 12.1 0.0 1.4 1 1 0 1 1 1 0 Zeta toxin Shikimate_DH PF01488.15 EDK39825.1 - 0.066 13.3 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Fungal_trans_2 PF11951.3 EDK39826.2 - 1.7e-67 227.6 6.7 2e-67 227.4 4.7 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_1_2 PF00155.16 EDK39827.2 - 2.3e-39 135.3 0.0 3.5e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Fungal_trans PF04082.13 EDK39828.2 - 1.2e-21 76.7 2.5 2.3e-21 75.8 1.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39828.2 - 0.00093 19.0 6.8 0.0017 18.1 4.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_A_type_inc PF04508.7 EDK39828.2 - 4.6 7.2 7.3 0.76 9.7 0.3 3.2 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Lyase_1 PF00206.15 EDK39829.2 - 4.8e-46 157.3 0.0 7.8e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 EDK39829.2 - 1.3e-20 73.1 0.0 5e-20 71.2 0.0 2.0 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Sugar_tr PF00083.19 EDK39830.2 - 4.6e-42 144.1 23.4 5.1e-42 143.9 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39830.2 - 1.2e-05 24.2 17.1 1.5e-05 23.8 11.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ABC2_membrane_2 PF12679.2 EDK39830.2 - 1.7 7.4 12.8 2.5 6.9 8.4 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein MFS_1 PF07690.11 EDK39831.1 - 1.7e-05 23.7 15.7 2e-05 23.4 10.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily adh_short PF00106.20 EDK39832.1 - 1.9e-11 44.1 0.0 2.2e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK39832.1 - 1.2e-07 31.6 0.0 1.4e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EDK39832.1 - 1.6e-06 28.0 0.0 1.9e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EDK39832.1 - 0.02 14.8 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 NADH(P)-binding Epimerase PF01370.16 EDK39832.1 - 0.026 13.9 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EDK39832.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.5 1 1 0 1 1 1 0 TrkA-N domain CRAL_TRIO_2 PF13716.1 EDK39833.2 - 0.016 15.1 0.3 0.038 13.8 0.2 1.6 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain Zn_clus PF00172.13 EDK39834.2 - 4.9e-06 26.3 12.1 4.9e-06 26.3 8.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1479 PF07350.7 EDK39835.2 - 6e-158 525.6 0.0 7.6e-158 525.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Fungal_trans PF04082.13 EDK39836.2 - 2.2e-12 46.4 0.3 4.2e-12 45.5 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.19 EDK39837.2 - 7.2e-70 235.7 25.4 7.2e-70 235.7 17.6 1.4 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39837.2 - 3.1e-22 78.7 32.1 9e-22 77.2 11.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1119 PF06550.6 EDK39837.2 - 0.0017 17.5 1.2 0.0026 16.9 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1119) DUF2809 PF10990.3 EDK39837.2 - 0.12 12.8 4.1 0.35 11.3 1.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2809) DUF1593 PF07632.6 EDK39838.2 - 9.6e-90 300.3 0.0 1.3e-89 299.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.10 EDK39838.2 - 0.015 13.6 0.0 0.037 12.3 0.0 1.5 1 1 0 1 1 1 0 REJ domain CotE PF10628.4 EDK39839.2 - 0.086 12.2 0.4 0.11 11.8 0.3 1.2 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) Zn_clus PF00172.13 EDK39840.2 - 0.0052 16.6 11.6 0.011 15.6 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1241 PF06840.6 EDK39840.2 - 0.037 13.2 0.2 3.3 6.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1241) M20_dimer PF07687.9 EDK39841.2 - 1.7e-06 27.7 0.0 2.3e-05 24.1 0.0 2.3 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 EDK39841.2 - 1.7e-06 27.6 0.0 2.7e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 MFS_1 PF07690.11 EDK39842.2 - 1.3e-37 129.3 32.5 1.3e-37 129.3 22.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily ESSS PF10183.4 EDK39842.2 - 0.011 16.1 0.1 0.034 14.5 0.1 1.9 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) MFS_1 PF07690.11 EDK39843.2 - 3.5e-08 32.5 45.1 9e-07 27.9 18.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK39843.2 - 0.00098 17.8 18.2 0.00098 17.8 12.6 2.6 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 EDK39843.2 - 1.2 7.4 39.5 0.0058 15.0 6.0 3.1 2 1 0 2 2 2 0 MFS/sugar transport protein LRR_8 PF13855.1 EDK39844.2 - 1.9e-08 33.9 9.4 2.9e-05 23.7 1.3 6.9 4 2 6 10 10 10 4 Leucine rich repeat LRR_4 PF12799.2 EDK39844.2 - 7.7e-06 25.4 39.7 0.054 13.1 1.3 9.3 2 1 5 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK39844.2 - 6.1e-05 22.5 34.4 1.4 9.2 0.1 10.9 10 3 2 12 12 12 4 Leucine Rich Repeat LRR_7 PF13504.1 EDK39844.2 - 0.0045 16.9 32.4 21 5.9 0.0 12.2 14 1 1 15 15 15 2 Leucine rich repeat tRNA_bind_2 PF13725.1 EDK39844.2 - 0.033 14.2 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 Possible tRNA binding domain Fungal_trans PF04082.13 EDK39845.2 - 3.9e-12 45.5 1.6 3.9e-12 45.5 1.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39845.2 - 6.4e-07 29.1 12.1 6.4e-07 29.1 8.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NotI PF12183.3 EDK39845.2 - 0.34 9.9 2.1 0.62 9.0 1.5 1.3 1 0 0 1 1 1 0 Restriction endonuclease NotI DUF2961 PF11175.3 EDK39846.1 - 1.1e-85 286.7 5.9 1.6e-85 286.2 4.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) Sugar_tr PF00083.19 EDK39847.2 - 7.9e-79 265.3 28.7 9.1e-79 265.1 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39847.2 - 1.8e-18 66.3 60.4 4.5e-17 61.8 23.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK39847.2 - 0.00047 18.6 30.3 0.0029 16.0 5.6 3.5 2 2 2 4 4 4 3 MFS/sugar transport protein RyR PF02026.11 EDK39848.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.4 1 1 0 1 1 1 0 RyR domain MFS_1 PF07690.11 EDK39849.2 - 1.9e-26 92.6 23.9 1.9e-26 92.6 16.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1485 PF07364.7 EDK39850.2 - 3.9e-74 249.4 0.0 5e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1485) MlrC_C PF07171.7 EDK39850.2 - 9.3e-24 83.9 0.0 1.3e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 MlrC C-terminus Fungal_trans PF04082.13 EDK39851.2 - 1.9e-31 108.9 2.6 2.6e-30 105.1 0.5 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39851.2 - 8.2e-06 25.6 17.7 1.3e-05 24.9 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FMO-like PF00743.14 EDK39852.2 - 1.8e-38 132.0 0.1 7.2e-26 90.4 0.0 2.7 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EDK39852.2 - 2.7e-20 73.3 0.0 5.3e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK39852.2 - 1.6e-16 60.4 0.0 1.7e-14 53.8 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EDK39852.2 - 1.2e-09 38.3 0.0 7.8e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK39852.2 - 3.2e-08 33.8 0.0 0.1 13.0 0.0 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK39852.2 - 1.1e-07 30.7 0.3 3.6e-05 22.4 0.0 2.9 2 1 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.1 EDK39852.2 - 2.5e-07 30.6 0.1 1.4e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 EDK39852.2 - 3.1e-07 29.6 0.1 0.00064 18.7 0.1 2.7 2 1 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 EDK39852.2 - 4e-05 22.6 0.0 0.00017 20.6 0.0 2.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 EDK39852.2 - 0.00028 19.6 0.0 0.33 9.5 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_oxidored PF12831.2 EDK39852.2 - 0.0014 17.7 0.0 0.14 11.2 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 EDK39852.2 - 0.006 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Autotrns_rpt PF12951.2 EDK39852.2 - 0.073 12.7 2.2 0.13 11.9 1.5 1.4 1 0 0 1 1 1 0 Autotransporter-associated beta strand repeat Thi4 PF01946.12 EDK39852.2 - 0.089 11.8 0.1 1.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.17 EDK39852.2 - 0.33 9.7 5.0 3.3 6.4 0.6 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EDK39852.2 - 0.75 8.7 3.2 0.45 9.4 0.4 1.8 2 0 0 2 2 2 0 FAD binding domain Sugar_tr PF00083.19 EDK39853.2 - 6.3e-79 265.6 28.1 7.2e-79 265.4 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39853.2 - 1e-19 70.4 60.4 3.6e-18 65.3 23.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK39853.2 - 4.5e-05 22.0 29.5 0.0011 17.5 1.7 3.4 3 1 1 4 4 4 2 MFS/sugar transport protein DUF2961 PF11175.3 EDK39854.1 - 9.7e-86 286.9 5.9 1.4e-85 286.3 4.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) Fungal_trans PF04082.13 EDK39855.2 - 1.1e-12 47.4 1.5 1.1e-12 47.4 1.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain LRR_4 PF12799.2 EDK39856.2 - 7e-09 35.1 43.5 0.035 13.7 0.8 10.6 7 4 4 11 11 11 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK39856.2 - 0.00035 20.2 39.1 1.9 8.7 0.1 12.5 11 3 2 13 13 13 3 Leucine Rich Repeat LRR_8 PF13855.1 EDK39856.2 - 0.00079 19.1 34.5 0.11 12.2 0.1 8.8 3 1 8 11 11 11 8 Leucine rich repeat FNIP PF05725.7 EDK39856.2 - 0.015 15.2 30.6 0.22 11.4 0.2 8.0 7 1 0 7 7 7 0 FNIP Repeat LRR_7 PF13504.1 EDK39856.2 - 0.019 15.0 28.6 60 4.5 0.1 12.2 12 2 0 12 12 12 0 Leucine rich repeat F-box-like_2 PF13013.1 EDK39856.2 - 0.11 12.1 1.6 15 5.3 0.1 2.7 2 0 0 2 2 2 0 F-box-like domain LRR_5 PF13306.1 EDK39856.2 - 0.17 11.6 6.9 0.6 9.8 0.0 4.2 4 1 0 4 4 4 0 Leucine rich repeats (6 copies) LRR_6 PF13516.1 EDK39856.2 - 3 8.1 19.7 18 5.8 0.1 8.8 10 0 0 10 10 10 0 Leucine Rich repeat HTH_AraC PF00165.18 EDK39857.2 - 0.0001 22.0 0.0 0.00031 20.4 0.0 1.9 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.2 EDK39857.2 - 0.0011 19.0 0.0 0.0025 17.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain LRR_4 PF12799.2 EDK39858.2 - 1.1e-15 56.8 37.6 0.0024 17.4 0.6 10.2 3 2 9 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK39858.2 - 1.5e-13 50.2 29.0 1.7e-08 34.1 1.7 7.6 5 4 3 8 8 8 4 Leucine rich repeat LRR_1 PF00560.28 EDK39858.2 - 2.1e-09 36.1 34.0 0.25 11.4 0.0 11.3 9 2 2 11 11 11 4 Leucine Rich Repeat LRR_7 PF13504.1 EDK39858.2 - 2.5e-07 29.7 37.4 6.5 7.4 0.1 13.6 14 2 1 15 15 15 3 Leucine rich repeat FNIP PF05725.7 EDK39858.2 - 0.033 14.1 0.4 0.033 14.1 0.3 6.2 7 2 1 8 8 8 0 FNIP Repeat LRR_6 PF13516.1 EDK39858.2 - 5.8 7.3 32.0 24 5.3 0.0 10.2 10 2 2 12 12 12 0 Leucine Rich repeat Asp PF00026.18 EDK39859.2 - 7.9e-71 238.8 13.1 9.4e-71 238.6 9.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK39859.2 - 8.6e-07 29.0 2.8 8.6e-07 29.0 2.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EDK39859.2 - 0.0072 15.8 0.2 2 7.9 0.0 2.4 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal Asp PF00026.18 EDK39860.2 - 4.2e-64 216.8 2.7 5.4e-64 216.4 1.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK39860.2 - 2e-05 24.5 0.2 4.5e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EDK39860.2 - 0.0011 18.6 0.0 0.037 13.5 0.0 2.6 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.18 EDK39861.2 - 7.2e-65 219.3 1.3 9.3e-65 218.9 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK39861.2 - 7.8e-06 25.9 0.4 1.6e-05 24.9 0.1 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 EDK39861.2 - 6.1e-05 22.6 0.0 0.00015 21.3 0.0 1.6 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 EDK39861.2 - 0.064 13.7 0.7 8.9 6.8 0.0 3.5 2 2 1 3 3 3 0 Aspartyl protease DUF1772 PF08592.6 EDK39862.2 - 5.1e-09 35.9 1.8 7.1e-09 35.5 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF2269 PF10027.4 EDK39862.2 - 0.14 11.9 3.2 0.17 11.6 2.2 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) KRTDAP PF15200.1 EDK39863.2 - 0.084 12.6 1.4 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 Keratinocyte differentiation-associated FMO-like PF00743.14 EDK39864.2 - 9.2e-33 113.2 0.1 2.3e-13 49.2 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EDK39864.2 - 4.9e-16 59.3 0.0 1.4e-15 57.9 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK39864.2 - 2.2e-07 30.1 0.3 1.4e-05 24.2 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EDK39864.2 - 7.3e-07 29.0 0.0 2.7e-05 24.0 0.0 3.2 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 EDK39864.2 - 2e-06 27.8 0.0 0.00033 20.5 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EDK39864.2 - 4.2e-06 26.0 0.2 0.0098 15.0 0.1 2.4 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.1 EDK39864.2 - 4.4e-06 26.6 0.0 1.6e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GATase PF00117.23 EDK39865.2 - 1e-09 38.0 0.0 1.7e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 EDK39865.2 - 0.01 15.2 0.0 0.034 13.5 0.0 1.8 1 1 0 1 1 1 0 Peptidase C26 DUF2894 PF11445.3 EDK39866.2 - 1.1 9.5 6.0 3.5 7.8 4.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) ADIP PF11559.3 EDK39866.2 - 1.2 9.0 5.8 4.7 7.0 0.3 2.6 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding zf-Tim10_DDP PF02953.10 EDK39867.1 - 9.4e-20 69.6 1.2 1.1e-19 69.4 0.8 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2454 PF10521.4 EDK39868.2 - 2.4e-67 226.8 0.2 3.1e-67 226.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) Indigoidine_A PF04227.7 EDK39869.2 - 7.9e-123 409.3 0.2 9e-123 409.1 0.1 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.19 EDK39870.2 - 0.0016 17.6 0.0 0.037 13.1 0.0 2.3 3 0 0 3 3 3 2 pfkB family carbohydrate kinase Chalcone PF02431.10 EDK39871.2 - 7e-58 195.3 0.0 9.7e-58 194.8 0.0 1.2 1 0 0 1 1 1 1 Chalcone-flavanone isomerase NTP_transferase PF00483.18 EDK39872.1 - 4e-49 167.1 0.0 5.6e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 EDK39872.1 - 2.2e-11 44.0 0.0 3.3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 EDK39872.1 - 2.6e-08 32.9 9.9 6.3e-08 31.7 0.9 4.1 4 1 0 4 4 4 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 EDK39872.1 - 0.0018 17.7 3.6 0.029 13.9 0.1 3.2 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.14 EDK39872.1 - 0.091 12.3 0.0 0.24 10.9 0.0 1.8 2 1 0 2 2 2 0 Cytidylyltransferase MFS_1 PF07690.11 EDK39874.2 - 1.6e-15 56.7 21.0 1.6e-15 56.7 14.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 EDK39874.2 - 1.5e-05 24.3 10.3 1.5e-05 24.3 7.1 2.3 2 0 0 2 2 2 1 Nodulin-like MFS_1_like PF12832.2 EDK39874.2 - 0.02 14.6 3.0 1.2 8.9 0.0 3.4 3 0 0 3 3 3 0 MFS_1 like family FBPase PF00316.15 EDK39875.2 - 3.9e-135 449.8 0.0 4.4e-135 449.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 EDK39875.2 - 0.037 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Inositol monophosphatase family SecY PF00344.15 EDK39877.2 - 7.9e-94 314.4 8.0 1e-93 314.0 5.5 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 EDK39877.2 - 2.5e-17 62.0 0.1 9.9e-17 60.1 0.1 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p LicD PF04991.8 EDK39878.2 - 2.3e-45 155.2 0.2 2.3e-45 155.2 0.2 2.9 3 1 1 4 4 4 1 LicD family LicD PF04991.8 EDK39879.2 - 5.9e-43 147.3 2.2 5.9e-43 147.3 1.5 3.9 3 1 0 3 3 3 1 LicD family Mgm101p PF06420.7 EDK39880.2 - 5.7e-90 299.1 0.0 8.4e-90 298.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Tim17 PF02466.14 EDK39881.1 - 0.011 15.7 1.0 0.026 14.5 0.7 1.5 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Polysacc_synt_3 PF13440.1 EDK39881.1 - 0.13 11.6 2.1 0.17 11.3 1.4 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MAS20 PF02064.10 EDK39882.2 - 2.6e-17 62.8 3.2 1.2e-16 60.7 2.2 1.8 1 1 0 1 1 1 1 MAS20 protein import receptor PI3K_p85B PF02192.11 EDK39882.2 - 0.018 14.4 0.3 0.056 12.8 0.0 1.9 1 1 1 2 2 2 0 PI3-kinase family, p85-binding domain Osmo_MPGsynth PF09488.5 EDK39882.2 - 0.039 12.6 0.4 0.1 11.2 0.0 1.7 1 1 1 2 2 2 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) DUF533 PF04391.7 EDK39882.2 - 0.077 12.3 0.4 0.15 11.4 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF533) Beta-Casp PF10996.3 EDK39882.2 - 0.098 12.5 1.1 0.34 10.8 0.8 1.8 1 1 0 1 1 1 0 Beta-Casp domain Cellulase PF00150.13 EDK39883.2 - 2.7e-14 53.0 7.5 2.7e-14 53.0 5.2 2.0 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.10 EDK39883.2 - 0.00047 19.3 3.0 0.0024 17.0 0.0 2.3 2 1 0 2 2 2 1 Beta-galactosidase Homoserine_dh PF00742.14 EDK39884.2 - 3.3e-53 180.0 0.0 4.8e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 EDK39884.2 - 2.9e-19 69.6 0.0 4.5e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 EDK39884.2 - 0.00015 22.0 0.0 0.00029 21.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Hydrolase_6 PF13344.1 EDK39884.2 - 0.086 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase 2-Hacid_dh_C PF02826.14 EDK39884.2 - 0.089 11.9 0.0 0.23 10.6 0.0 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3608 PF12257.3 EDK39885.2 - 8.3e-145 480.9 1.5 1.3e-144 480.2 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 EDK39885.2 - 4.4e-26 90.4 0.2 9.7e-26 89.3 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SNO PF01174.14 EDK39886.1 - 2.8e-63 212.9 0.0 1e-61 207.8 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 EDK39886.1 - 3.6e-11 42.8 0.0 2.9e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.12 EDK39886.1 - 0.0014 18.3 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.19 EDK39886.1 - 0.0016 17.9 0.0 0.0023 17.4 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.23 EDK39886.1 - 0.0016 17.8 0.1 0.0094 15.4 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I BPL_N PF09825.4 EDK39886.1 - 0.013 14.3 0.0 0.098 11.4 0.0 1.9 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal DUF4154 PF13689.1 EDK39886.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4154) DUF4066 PF13278.1 EDK39886.1 - 0.036 13.3 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative amidotransferase SOR_SNZ PF01680.12 EDK39887.1 - 2e-105 350.9 9.5 2.9e-105 350.4 6.6 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 EDK39887.1 - 3.3e-10 39.4 5.6 5.7e-09 35.4 0.1 2.6 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.12 EDK39887.1 - 5.1e-05 22.2 0.1 0.012 14.4 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.9 EDK39887.1 - 5.8e-05 22.1 1.2 0.00077 18.4 0.1 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.16 EDK39887.1 - 0.0038 16.5 0.1 0.067 12.4 0.0 2.6 2 1 1 3 3 3 1 Histidine biosynthesis protein IGPS PF00218.16 EDK39887.1 - 0.019 14.0 0.0 0.05 12.6 0.0 1.7 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase NMO PF03060.10 EDK39887.1 - 0.043 12.9 2.0 0.095 11.8 0.1 2.1 2 0 0 2 2 2 0 Nitronate monooxygenase Ribosomal_S5_C PF03719.10 EDK39887.1 - 0.044 13.0 0.0 0.1 11.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain PEP_mutase PF13714.1 EDK39887.1 - 0.085 12.0 1.1 0.52 9.4 0.1 2.5 2 1 1 3 3 3 0 Phosphoenolpyruvate phosphomutase Peroxin-22 PF12827.2 EDK39888.2 - 5.9e-37 125.9 1.4 8.3e-37 125.4 1.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family DUF1836 PF08876.6 EDK39888.2 - 0.061 13.0 3.5 0.24 11.1 0.2 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1836) RasGEF PF00617.14 EDK39889.2 - 1.7e-49 168.1 2.5 3.2e-49 167.2 1.8 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 EDK39889.2 - 6.7e-20 71.1 3.2 4.2e-19 68.5 0.9 3.0 3 0 0 3 3 3 1 RasGEF N-terminal motif Fork_head PF00250.13 EDK39890.2 - 1e-19 70.3 0.3 2.7e-19 68.9 0.2 1.7 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 EDK39890.2 - 1.2e-09 38.1 0.2 2.5e-09 37.0 0.2 1.6 1 0 0 1 1 1 1 FHA domain Proteasome PF00227.21 EDK39891.1 - 1.1e-47 161.7 0.2 1.6e-47 161.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_L5_C PF00673.16 EDK39892.1 - 2.4e-23 81.6 0.1 3.7e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 EDK39892.1 - 2.9e-20 71.8 0.1 8e-20 70.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 BCAS2 PF05700.6 EDK39893.2 - 1e-14 54.5 12.5 1.9e-13 50.4 8.6 2.0 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) PHF5 PF03660.9 EDK39894.2 - 9.8e-49 163.8 12.7 1.1e-48 163.6 8.8 1.0 1 0 0 1 1 1 1 PHF5-like protein zinc-ribbons_6 PF07191.7 EDK39894.2 - 0.00023 20.8 4.3 0.00023 20.8 3.0 1.8 1 1 1 2 2 2 1 zinc-ribbons UPF0547 PF10571.4 EDK39894.2 - 0.01 15.4 2.3 0.01 15.4 1.6 2.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DZR PF12773.2 EDK39894.2 - 2.4 8.0 15.1 10 6.0 5.8 3.3 1 1 1 2 2 2 0 Double zinc ribbon Ribosomal_S14 PF00253.16 EDK39894.2 - 6.1 6.3 6.5 0.34 10.3 0.5 2.0 2 1 0 2 2 2 0 Ribosomal protein S14p/S29e zf-RING_2 PF13639.1 EDK39895.2 - 1.1e-09 37.9 13.0 1.1e-09 37.9 9.0 2.4 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.24 EDK39895.2 - 2.7e-07 30.1 6.0 2.7e-07 30.1 4.2 2.6 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.2 EDK39895.2 - 2.5e-05 24.2 10.2 2.5e-05 24.2 7.1 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 EDK39895.2 - 0.00037 20.2 6.1 0.00037 20.2 4.2 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 EDK39895.2 - 0.00075 19.1 7.9 0.00075 19.1 5.5 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 EDK39895.2 - 0.0063 16.5 11.6 0.0063 16.5 8.0 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 EDK39895.2 - 0.01 15.7 12.4 0.42 10.6 3.3 2.9 3 0 0 3 3 3 0 FANCL C-terminal domain PHD_2 PF13831.1 EDK39895.2 - 0.011 15.0 1.5 0.011 15.0 1.1 2.7 3 0 0 3 3 3 0 PHD-finger zf-PHD-like PF15446.1 EDK39895.2 - 0.012 14.9 0.9 0.012 14.9 0.6 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-C3HC4 PF00097.20 EDK39895.2 - 0.021 14.4 10.9 0.021 14.4 7.5 2.9 2 1 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-4CXXC_R1 PF10497.4 EDK39895.2 - 1.4 9.0 7.7 3.7 7.7 1.2 2.7 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Cofilin_ADF PF00241.15 EDK39896.2 - 6.8e-26 90.6 0.1 1.7e-12 47.3 0.1 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF498 PF04430.9 EDK39897.1 - 1.5e-18 66.3 0.0 2e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Pil1 PF13805.1 EDK39899.2 - 3.6e-154 511.6 0.2 4.2e-154 511.4 0.2 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.6 EDK39899.2 - 0.0057 16.0 1.2 0.0084 15.4 0.9 1.2 1 0 0 1 1 1 1 FAM92 protein V_ATPase_I PF01496.14 EDK39899.2 - 0.22 9.3 0.5 0.27 9.0 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mpv17_PMP22 PF04117.7 EDK39900.2 - 2.2e-22 78.4 5.9 2.2e-22 78.4 4.1 1.6 1 1 0 1 1 1 1 Mpv17 / PMP22 family Mpv17_PMP22 PF04117.7 EDK39901.1 - 6.7e-26 89.7 5.6 1.1e-25 88.9 3.9 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family B56 PF01603.15 EDK39902.2 - 1.4e-151 504.7 12.5 2.7e-142 474.1 5.7 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) DUF1002 PF06207.6 EDK39902.2 - 3.2 7.0 6.3 5.5 6.2 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) IMPDH PF00478.20 EDK39903.1 - 9.4e-142 472.0 3.9 1.1e-141 471.8 2.7 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 EDK39903.1 - 3.1e-13 49.2 0.0 2.5e-06 27.1 0.0 2.4 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 EDK39903.1 - 2.4e-09 36.7 4.0 5.1e-06 25.8 0.9 2.6 3 0 0 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.13 EDK39903.1 - 3.7e-08 32.6 1.2 1.6e-07 30.5 0.9 1.9 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EDK39903.1 - 1.3e-05 24.5 0.7 6.9e-05 22.2 0.5 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 EDK39903.1 - 7.1e-05 22.0 2.0 0.00059 18.9 0.3 2.3 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG Aldolase PF01081.14 EDK39903.1 - 0.0036 16.4 0.1 0.014 14.5 0.0 2.0 1 0 0 1 1 1 1 KDPG and KHG aldolase DUF1273 PF06908.6 EDK39903.1 - 0.081 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1273) MFS_1 PF07690.11 EDK39904.2 - 3.3e-15 55.6 38.3 9e-10 37.7 19.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK39904.2 - 8.9e-06 24.1 17.7 1.2e-05 23.7 12.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) S1FA PF04689.8 EDK39904.2 - 1.5 8.7 7.0 2.2 8.2 1.3 3.0 1 1 1 2 2 2 0 DNA binding protein S1FA Glyco_hydro_20 PF00728.17 EDK39905.2 - 1.4e-93 313.8 0.4 1.7e-93 313.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 EDK39905.2 - 1.4e-11 45.1 0.0 3.8e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 EDK39905.2 - 0.004 17.6 0.0 0.0064 17.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Epimerase PF01370.16 EDK39906.2 - 2.6e-26 92.5 0.1 3.5e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK39906.2 - 3.1e-26 91.7 0.1 3.8e-26 91.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK39906.2 - 1.6e-17 64.1 1.0 2.9e-17 63.2 0.7 1.5 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK39906.2 - 7.4e-17 61.1 0.0 9.3e-17 60.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EDK39906.2 - 1.2e-10 41.0 0.6 1.7e-08 34.0 0.1 2.2 2 0 0 2 2 2 2 NmrA-like family Polysacc_synt_2 PF02719.10 EDK39906.2 - 2e-09 36.7 0.2 2e-09 36.7 0.2 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EDK39906.2 - 2.2e-06 27.7 2.5 5.5e-06 26.4 1.7 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK39906.2 - 0.00025 20.7 2.6 0.00073 19.2 1.8 1.7 1 1 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 EDK39906.2 - 0.043 12.7 0.3 0.057 12.3 0.2 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase FAM209 PF15206.1 EDK39906.2 - 0.046 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 FAM209 family Ldh_1_N PF00056.18 EDK39906.2 - 0.17 11.7 0.7 0.64 9.8 0.1 2.1 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain p450 PF00067.17 EDK39907.2 - 4.4e-64 216.7 1.0 5.6e-64 216.3 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.19 EDK39908.1 - 1.9e-109 366.2 25.6 2.5e-109 365.8 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK39908.1 - 4.2e-20 71.7 36.4 2e-14 53.0 8.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HlyIII PF03006.15 EDK39909.2 - 2.7e-54 183.9 5.8 3.8e-54 183.4 4.0 1.2 1 0 0 1 1 1 1 Haemolysin-III related LicD PF04991.8 EDK39910.2 - 7.3e-43 147.0 0.3 7.3e-43 147.0 0.2 3.5 3 1 0 3 3 3 1 LicD family Aldo_ket_red PF00248.16 EDK39911.2 - 3e-50 170.6 0.1 4.1e-50 170.1 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Peripla_BP_4 PF13407.1 EDK39911.2 - 0.068 12.5 0.0 0.25 10.6 0.0 2.0 2 1 0 2 2 2 0 Periplasmic binding protein domain Ada_Zn_binding PF02805.11 EDK39912.2 - 6.6e-28 96.0 1.4 1e-27 95.4 1.0 1.3 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.18 EDK39912.2 - 2.9e-05 23.7 0.1 5.5e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.2 EDK39912.2 - 0.0018 18.3 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3818 PF12825.2 EDK39913.2 - 3.6e-118 394.1 11.2 7e-118 393.1 7.8 1.5 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 EDK39913.2 - 1.9e-43 147.3 0.9 6.4e-43 145.6 0.6 1.9 1 0 0 1 1 1 1 PX-associated PX PF00787.19 EDK39913.2 - 9.6e-08 31.8 1.8 2.3e-07 30.6 0.4 2.4 2 0 0 2 2 2 1 PX domain CAF1 PF04857.15 EDK39915.2 - 5.4e-40 137.3 1.4 5.4e-40 137.3 1.0 1.5 2 0 0 2 2 2 1 CAF1 family ribonuclease Lum_binding PF00677.12 EDK39915.2 - 0.076 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Lumazine binding domain zf-HC5HC2H PF13771.1 EDK39916.2 - 3 8.0 10.6 27 4.9 0.1 3.5 3 0 0 3 3 3 0 PHD-like zinc-binding domain zf-CCHC_4 PF14392.1 EDK39916.2 - 7.6 6.2 7.8 6.9 6.4 0.1 2.9 3 0 0 3 3 3 0 Zinc knuckle PA28_alpha PF02251.13 EDK39917.1 - 0.03 14.4 1.3 5.2 7.3 0.0 4.0 1 1 3 4 4 4 0 Proteasome activator pa28 alpha subunit PRANC PF09372.5 EDK39917.1 - 0.13 12.2 0.0 11 6.1 0.0 2.3 1 1 0 2 2 2 0 PRANC domain DUF3350 PF11830.3 EDK39917.1 - 0.28 11.2 1.7 16 5.6 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3350) Phytoreo_Pns PF05451.6 EDK39917.1 - 0.36 9.4 2.4 0.5 8.9 1.3 1.5 1 1 1 2 2 2 0 Phytoreovirus nonstructural protein Pns10/11 RGS PF00615.14 EDK39917.1 - 0.53 10.3 6.4 3.5 7.7 0.1 3.9 2 2 1 4 4 4 0 Regulator of G protein signaling domain Mga PF05043.8 EDK39917.1 - 0.59 10.4 10.2 0.065 13.5 1.5 2.5 1 1 2 3 3 3 0 Mga helix-turn-helix domain Lact-deh-memb PF09330.6 EDK39917.1 - 0.81 9.0 3.7 1.6 8.0 1.8 1.8 1 1 1 2 2 2 0 D-lactate dehydrogenase, membrane binding CDC50 PF03381.10 EDK39918.1 - 2.3e-100 335.3 4.1 2.8e-100 335.0 2.8 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family NTF2 PF02136.15 EDK39919.2 - 7.8e-14 52.0 0.0 1.5e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 EDK39919.2 - 0.0095 15.5 0.0 0.024 14.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UQ_con PF00179.21 EDK39920.2 - 2e-43 147.1 0.0 2.5e-43 146.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 EDK39920.2 - 2.4e-18 65.4 0.1 3.8e-18 64.8 0.1 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.1 EDK39920.2 - 7.4e-05 22.5 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EDK39920.2 - 0.06 13.2 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain UBA_2 PF08587.6 EDK39920.2 - 0.076 13.2 0.1 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) GN3L_Grn1 PF08701.6 EDK39920.2 - 0.14 12.1 0.4 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase Not1 PF04054.10 EDK39921.2 - 2.6e-146 487.3 0.1 7.3e-146 485.8 0.0 1.9 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 EDK39921.2 - 5.4e-30 104.0 2.1 9.3e-30 103.2 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) RabGAP-TBC PF00566.13 EDK39922.2 - 6.1e-39 133.7 5.4 1.3e-38 132.6 3.8 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Fer2_3 PF13085.1 EDK39922.2 - 0.046 13.5 0.2 0.14 11.9 0.2 1.8 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Rap1-DNA-bind PF09197.5 EDK39922.2 - 0.25 11.8 2.0 0.81 10.2 0.0 2.8 3 1 0 3 3 3 0 Rap1, DNA-binding DUF814 PF05670.8 EDK39923.2 - 7.5e-19 67.4 2.0 9.1e-19 67.1 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF814) PMD PF10536.4 EDK39923.2 - 0.036 13.0 0.9 0.039 12.9 0.6 1.1 1 0 0 1 1 1 0 Plant mobile domain HSP70 PF00012.15 EDK39923.2 - 0.68 7.7 9.8 0.57 8.0 0.0 2.0 2 0 0 2 2 2 0 Hsp70 protein 2OG-FeII_Oxy_5 PF13759.1 EDK39923.2 - 0.79 10.0 5.2 1.2 9.4 0.1 3.0 1 1 2 3 3 3 0 Putative 2OG-Fe(II) oxygenase COX6B PF02297.12 EDK39924.1 - 4.9e-18 64.9 4.2 5.7e-18 64.6 2.9 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Somatostatin PF03002.10 EDK39924.1 - 0.0089 15.6 2.0 0.018 14.6 1.4 1.5 1 0 0 1 1 1 1 Somatostatin/Cortistatin family CHCH PF06747.8 EDK39924.1 - 0.032 14.1 0.7 0.052 13.4 0.5 1.4 1 0 0 1 1 1 0 CHCH domain UPF0203 PF05254.7 EDK39924.1 - 0.43 10.4 4.3 0.73 9.7 1.3 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) FNIP_N PF14636.1 EDK39925.2 - 8 6.9 9.1 7.1 7.1 5.6 1.5 1 1 0 1 1 1 0 Folliculin-interacting protein N-terminus Aminotran_5 PF00266.14 EDK39926.2 - 4.7e-24 84.8 0.0 5.5e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 EDK39926.2 - 0.013 14.4 0.2 0.024 13.5 0.1 1.3 1 1 0 1 1 1 0 Aminotransferase class I and II MS_channel PF00924.13 EDK39926.2 - 0.047 13.0 0.4 0.095 12.0 0.2 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel adh_short PF00106.20 EDK39926.2 - 0.077 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase DnaJ PF00226.26 EDK39927.2 - 2e-20 72.2 1.2 6.7e-20 70.5 0.9 2.0 1 0 0 1 1 1 1 DnaJ domain PTH2 PF01981.11 EDK39927.2 - 0.026 14.2 0.4 0.057 13.1 0.3 1.6 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 BING4CT PF08149.6 EDK39927.2 - 0.14 11.6 0.6 0.88 9.1 0.1 2.3 2 0 0 2 2 2 0 BING4CT (NUC141) domain CTNNBL PF08216.6 EDK39927.2 - 1.1 8.8 7.0 0.45 10.1 2.6 2.0 2 1 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear DUF4441 PF14536.1 EDK39927.2 - 1.2 9.0 7.3 0.63 10.0 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) Fib_alpha PF08702.5 EDK39927.2 - 4.3 7.4 7.4 0.89 9.6 2.5 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DNA_topoisoIV PF00521.15 EDK39928.2 - 1.2e-124 416.4 0.5 2.4e-124 415.4 0.0 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 EDK39928.2 - 4.4e-37 126.9 3.0 1.2e-36 125.5 2.1 1.7 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 EDK39928.2 - 8.1e-12 44.9 0.0 4e-11 42.7 0.0 2.2 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 EDK39928.2 - 2.2e-09 37.0 0.0 5.7e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GTP_cyclohydro2 PF00925.15 EDK39929.1 - 4.7e-59 198.4 0.0 1.2e-53 180.8 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II Fungal_trans PF04082.13 EDK39930.2 - 5.3e-34 117.2 1.7 9.4e-34 116.4 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK39930.2 - 1.3e-09 37.7 10.8 1.3e-09 37.7 7.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pigment_DH PF06324.6 EDK39930.2 - 0.0017 17.5 0.0 0.0017 17.5 0.0 2.4 2 0 0 2 2 2 1 Pigment-dispersing hormone (PDH) RNase_PH PF01138.16 EDK39931.1 - 1e-25 90.5 0.1 1.6e-25 89.9 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.8 EDK39932.2 - 5.4e-58 193.6 8.5 1.2e-35 121.8 0.5 3.0 2 0 0 2 2 2 2 Phospholipid methyltransferase GPI-anchored PF10342.4 EDK39932.2 - 0.04 14.4 0.1 0.13 12.7 0.1 2.0 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CALCOCO1 PF07888.6 EDK39932.2 - 0.042 12.1 0.2 0.068 11.4 0.1 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DEAD PF00270.24 EDK39933.2 - 3.3e-44 150.3 0.0 1.9e-43 147.8 0.0 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39933.2 - 3.5e-11 42.7 0.0 1.3e-10 40.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK39933.2 - 0.00029 20.7 0.0 0.00082 19.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 EDK39933.2 - 0.0073 15.8 0.0 0.8 9.2 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EDK39933.2 - 0.026 14.2 0.3 5.4 6.8 0.0 2.9 2 1 0 2 2 2 0 Part of AAA domain RNA_pol_L_2 PF13656.1 EDK39934.2 - 3.1e-31 106.6 0.1 4e-31 106.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 EDK39934.2 - 1.1e-13 50.0 0.0 1.5e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SID PF11778.3 EDK39935.2 - 1.6e-12 47.5 1.3 3.3e-12 46.4 0.4 1.9 1 1 1 2 2 2 1 Septation initiation Striatin PF08232.7 EDK39935.2 - 0.015 15.5 0.5 0.015 15.5 0.4 2.2 2 1 0 2 2 2 0 Striatin family DivIC PF04977.10 EDK39935.2 - 1.3 8.5 7.0 0.28 10.6 2.2 1.8 2 0 0 2 2 2 0 Septum formation initiator CENP-F_N PF10481.4 EDK39935.2 - 2.3 7.5 8.1 0.13 11.6 0.6 2.2 2 1 0 2 2 2 0 Cenp-F N-terminal domain zf-H2C2_2 PF13465.1 EDK39936.2 - 2e-22 78.2 26.9 1.5e-08 34.4 0.4 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.21 EDK39936.2 - 4.6e-22 76.9 30.3 1.3e-05 25.2 0.7 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK39936.2 - 1.5e-15 56.2 23.9 0.00031 20.8 1.9 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.2 EDK39936.2 - 3.4e-06 27.0 14.2 0.0051 16.9 0.1 4.5 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 EDK39936.2 - 1.5e-05 25.0 12.2 0.085 13.0 0.1 4.1 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EDK39936.2 - 0.00013 21.7 17.7 0.036 13.9 0.8 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.7 EDK39936.2 - 0.0014 18.6 8.2 0.13 12.3 0.9 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.6 EDK39936.2 - 0.11 12.1 2.3 0.65 9.6 0.2 3.1 1 1 2 3 3 3 0 GAGA factor Cytochrome_C7 PF14522.1 EDK39936.2 - 0.46 10.1 11.5 1.3 8.6 8.0 1.8 1 1 0 1 1 1 0 Cytochrome c7 zf-BED PF02892.10 EDK39936.2 - 0.51 10.1 21.1 0.36 10.6 1.8 3.9 3 1 1 4 4 4 0 BED zinc finger zf-C2HC_2 PF13913.1 EDK39936.2 - 0.62 9.7 9.4 2.1 8.1 0.2 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-CHCC PF10276.4 EDK39936.2 - 2.5 7.9 10.4 1.8 8.4 0.5 2.7 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_2 PF12756.2 EDK39936.2 - 4.3 7.5 14.3 3.8 7.6 0.9 3.5 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF221 PF02714.10 EDK39937.2 - 1.1e-111 372.8 25.9 2e-111 371.9 18.0 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EDK39937.2 - 8.2e-40 135.9 1.5 8.2e-40 135.9 1.0 2.7 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 EDK39937.2 - 2.2e-30 104.3 0.0 5.8e-30 103.0 0.0 1.8 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 EDK39937.2 - 1.4e-18 67.1 0.9 1.4e-18 67.1 0.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4463) IncA PF04156.9 EDK39937.2 - 0.1 12.1 5.4 0.22 11.0 0.0 3.2 3 1 0 3 3 3 0 IncA protein Pyrophosphatase PF00719.14 EDK39938.2 - 8.8e-53 177.9 0.0 1.1e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.4 EDK39939.2 - 1.5e-194 648.6 31.9 1.5e-194 648.6 22.1 1.8 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 GHMP_kinases_N PF00288.21 EDK39940.2 - 1.2e-18 66.9 0.4 3.3e-18 65.5 0.3 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EDK39940.2 - 1.6e-08 34.6 0.0 6e-08 32.7 0.0 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.4 EDK39940.2 - 0.00083 18.5 0.7 0.0048 16.1 0.0 2.2 2 0 0 2 2 2 1 Galactokinase galactose-binding signature Mtc PF03820.12 EDK39941.2 - 8.8e-114 379.2 0.2 9.8e-114 379.1 0.1 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier ACPS PF01648.15 EDK39942.1 - 1.5e-12 47.3 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily EABR PF12180.3 EDK39942.1 - 0.018 14.3 0.0 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 TSG101 and ALIX binding domain of CEP55 HicB PF05534.7 EDK39942.1 - 0.14 11.7 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 HicB family GMP_synt_C PF00958.17 EDK39943.2 - 1.2e-39 133.8 0.2 4.7e-39 132.0 0.1 2.0 2 0 0 2 2 2 1 GMP synthase C terminal domain GATase PF00117.23 EDK39943.2 - 1.8e-39 135.1 0.0 3.3e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 EDK39943.2 - 1.1e-09 37.6 0.0 4.4e-06 25.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 EDK39943.2 - 8.7e-09 35.1 0.2 4.5e-08 32.8 0.0 2.3 2 1 0 2 2 2 1 Peptidase C26 QueC PF06508.8 EDK39943.2 - 0.0015 17.8 0.0 0.026 13.7 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 EDK39943.2 - 0.0048 16.3 0.0 0.01 15.2 0.0 1.6 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 EDK39943.2 - 0.026 13.1 0.0 0.046 12.2 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase ATP_bind_3 PF01171.15 EDK39943.2 - 0.049 13.1 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 PP-loop family HOASN PF14515.1 EDK39943.2 - 0.084 13.2 0.2 0.19 12.1 0.2 1.5 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices WD40 PF00400.27 EDK39945.2 - 3.5e-39 131.2 12.5 1.1e-09 37.8 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat NLE PF08154.7 EDK39945.2 - 2.8e-26 91.3 0.5 4.3e-26 90.7 0.3 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 EDK39945.2 - 3.3e-07 28.8 3.0 0.00069 17.8 0.7 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Hanta_G1 PF01567.11 EDK39945.2 - 0.042 12.1 0.0 0.065 11.4 0.0 1.2 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 N2227 PF07942.7 EDK39946.2 - 7.1e-52 176.0 0.6 9.3e-52 175.6 0.4 1.1 1 0 0 1 1 1 1 N2227-like protein DUF4375 PF14300.1 EDK39946.2 - 0.19 11.7 3.2 0.15 12.0 0.3 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4375) PPTA PF01239.17 EDK39947.2 - 6.9e-38 126.4 18.6 5e-10 38.3 1.5 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PSCyt2 PF07583.6 EDK39947.2 - 0.027 14.0 0.7 0.17 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1549) Hist_deacetyl PF00850.14 EDK39948.2 - 4.3e-66 223.3 0.1 6.7e-66 222.7 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain RhoGAP PF00620.22 EDK39949.2 - 1.9e-17 63.3 0.0 3.7e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PX PF00787.19 EDK39949.2 - 2.5e-07 30.4 0.1 6.4e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 PX domain PH PF00169.24 EDK39949.2 - 3e-07 30.5 0.0 1e-06 28.8 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 EDK39949.2 - 0.014 15.6 0.2 0.13 12.5 0.1 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain PH_6 PF15406.1 EDK39949.2 - 0.038 14.0 0.0 0.14 12.2 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain DUF2215 PF10225.4 EDK39949.2 - 5.1 6.4 10.7 0.17 11.3 3.2 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) Kinetocho_Slk19 PF12709.2 EDK39950.2 - 3.6e-25 87.8 9.7 3.6e-25 87.8 6.7 3.3 3 0 0 3 3 3 1 Central kinetochore-associated DUF4456 PF14644.1 EDK39950.2 - 0.0043 16.2 12.7 0.0043 16.2 8.8 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4456) DUF883 PF05957.8 EDK39950.2 - 0.01 16.1 6.3 0.01 16.1 4.4 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF3107 PF11305.3 EDK39950.2 - 0.012 15.4 1.3 0.031 14.1 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3107) Spectrin PF00435.16 EDK39950.2 - 0.017 15.3 26.7 0.067 13.4 10.7 2.8 1 1 2 3 3 3 0 Spectrin repeat DUF1202 PF06717.6 EDK39950.2 - 0.019 14.2 16.1 0.074 12.3 4.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1202) TPR_MLP1_2 PF07926.7 EDK39950.2 - 0.034 13.8 35.7 0.11 12.1 2.0 3.1 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Sbi-IV PF11621.3 EDK39950.2 - 0.051 13.7 0.4 0.051 13.7 0.3 3.1 3 2 0 3 3 3 0 C3 binding domain 4 of IgG-bind protein SBI DUF2465 PF10239.4 EDK39950.2 - 0.076 12.2 13.3 0.095 11.8 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) WD40_alt PF14077.1 EDK39950.2 - 0.076 12.6 2.3 0.3 10.7 0.3 2.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif Acetyltransf_5 PF13444.1 EDK39950.2 - 0.11 13.1 1.1 0.2 12.2 0.2 1.8 2 1 0 2 2 1 0 Acetyltransferase (GNAT) domain YvrJ PF12841.2 EDK39950.2 - 0.13 11.5 6.6 1.3 8.3 1.3 3.4 4 0 0 4 4 3 0 YvrJ protein family Apolipoprotein PF01442.13 EDK39950.2 - 0.15 11.5 29.5 0.023 14.1 14.3 2.5 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain PilJ PF13675.1 EDK39950.2 - 0.15 12.3 13.9 1.4e+02 2.8 9.6 3.1 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term ADIP PF11559.3 EDK39950.2 - 0.21 11.4 39.2 0.17 11.7 8.6 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 EDK39950.2 - 0.27 10.8 34.0 0.13 11.8 15.5 2.2 1 1 0 2 2 2 0 IncA protein FlxA PF14282.1 EDK39950.2 - 0.3 11.0 35.0 1.4 8.8 13.6 3.3 1 1 2 3 3 3 0 FlxA-like protein DUF972 PF06156.8 EDK39950.2 - 0.31 11.4 29.8 0.21 11.9 8.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF2937 PF11157.3 EDK39950.2 - 0.31 10.3 7.8 0.09 12.1 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) YlqD PF11068.3 EDK39950.2 - 0.41 10.6 30.3 0.51 10.3 10.6 2.4 1 1 1 2 2 2 0 YlqD protein MADF_DNA_bdg PF10545.4 EDK39950.2 - 0.52 10.5 8.6 0.12 12.6 1.4 2.6 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Peptidase_S49 PF01343.13 EDK39950.2 - 0.53 10.0 11.2 0.74 9.5 2.0 2.3 1 1 1 2 2 2 0 Peptidase family S49 DUF3584 PF12128.3 EDK39950.2 - 0.57 7.4 27.1 0.89 6.7 18.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Dynactin_p62 PF05502.8 EDK39950.2 - 0.62 8.7 11.4 0.73 8.5 7.9 1.1 1 0 0 1 1 1 0 Dynactin p62 family Mod_r PF07200.8 EDK39950.2 - 0.8 9.6 29.7 2.9 7.7 14.7 2.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4618 PF15397.1 EDK39950.2 - 1 8.6 30.8 2.3 7.5 21.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Rootletin PF15035.1 EDK39950.2 - 1.1 9.2 29.4 0.15 11.9 5.4 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.5 EDK39950.2 - 1.2 9.2 26.6 0.48 10.5 12.3 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1825 PF08855.5 EDK39950.2 - 1.6 8.7 13.4 1.5 8.8 7.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1825) ZYG-11_interact PF05884.7 EDK39950.2 - 2 7.3 3.5 2.6 7.0 2.4 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF999 PF06198.6 EDK39950.2 - 2.1 8.1 8.4 1 9.1 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF999) Alg14 PF08660.6 EDK39950.2 - 2.5 8.0 5.6 0.38 10.7 1.1 1.7 2 0 0 2 2 1 0 Oligosaccharide biosynthesis protein Alg14 like PA26 PF04636.8 EDK39950.2 - 2.7 6.6 12.6 3.2 6.3 8.7 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4404 PF14357.1 EDK39950.2 - 2.7 8.4 27.6 0.34 11.3 7.8 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) bZIP_1 PF00170.16 EDK39950.2 - 3.1 7.8 27.3 2.9 7.9 1.6 3.9 3 1 1 4 4 4 0 bZIP transcription factor KfrA_N PF11740.3 EDK39950.2 - 3.2 8.2 19.0 1.5 9.3 2.9 3.3 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term Reo_sigmaC PF04582.7 EDK39950.2 - 3.4 6.7 8.1 1.3 8.0 2.4 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Cauli_DNA-bind PF03310.8 EDK39950.2 - 4.4 7.1 13.6 1.3 8.8 6.1 2.1 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein TSC22 PF01166.13 EDK39950.2 - 4.8 7.2 18.5 1.5 8.8 3.7 3.4 3 1 0 3 3 3 0 TSC-22/dip/bun family ATG16 PF08614.6 EDK39950.2 - 6.4 6.5 32.2 1.5 8.6 12.8 2.4 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) DivIC PF04977.10 EDK39950.2 - 9.7 5.7 35.5 4.4 6.8 1.9 4.2 1 1 2 3 3 3 0 Septum formation initiator DUF479 PF04336.7 EDK39950.2 - 10 6.3 10.4 6.4 6.9 2.0 3.0 2 1 1 3 3 3 0 Protein of unknown function, DUF479 IncA PF04156.9 EDK39951.2 - 0.003 17.1 29.2 0.003 17.1 20.3 3.6 1 1 1 2 2 2 1 IncA protein GAS PF13851.1 EDK39951.2 - 2.7 7.1 59.1 0.059 12.5 15.3 3.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 EDK39951.2 - 4 6.5 24.4 0.11 11.6 7.5 2.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3552 PF12072.3 EDK39951.2 - 4.4 6.4 61.2 0.17 11.0 20.4 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF3552) DUF972 PF06156.8 EDK39951.2 - 6.1 7.2 46.3 5.1 7.4 7.2 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Peptidase_M20 PF01546.23 EDK39953.2 - 1.2e-23 83.6 0.0 1.7e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK39953.2 - 3e-11 43.0 0.0 5.5e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EDK39953.2 - 0.00044 20.0 0.1 0.0018 18.0 0.1 1.9 1 1 0 1 1 1 1 Peptidase family M28 PyrBI_leader PF08052.6 EDK39953.2 - 0.12 12.2 0.1 0.33 10.7 0.1 1.7 1 0 0 1 1 1 0 PyrBI operon leader peptide RNA_pol_N PF01194.12 EDK39954.1 - 1.8e-29 101.5 1.1 2.1e-29 101.3 0.7 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Slx4 PF09494.5 EDK39954.1 - 0.062 13.0 0.3 1.2 8.8 0.0 2.0 1 1 1 2 2 2 0 Slx4 endonuclease WD40 PF00400.27 EDK39955.2 - 6.6e-07 28.9 10.9 0.00055 19.7 0.0 7.0 6 2 1 7 7 7 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 EDK39955.2 - 0.26 10.0 3.1 0.1 11.3 0.2 1.7 2 0 0 2 2 2 0 Coatomer WD associated region Dynamin_N PF00350.18 EDK39956.2 - 3.3e-42 144.1 0.0 7.5e-42 143.0 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.15 EDK39956.2 - 1.9e-06 26.8 1.2 0.00035 19.4 0.1 2.5 2 1 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 EDK39956.2 - 0.00055 19.8 0.0 0.0028 17.6 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK39956.2 - 0.0017 18.8 0.0 0.0047 17.4 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Sigma70_ner PF04546.8 EDK39956.2 - 0.011 15.3 2.4 0.032 13.8 1.7 1.8 1 0 0 1 1 1 0 Sigma-70, non-essential region SRI PF08236.6 EDK39956.2 - 0.012 15.4 0.4 0.36 10.8 0.1 2.9 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain DUF4248 PF14053.1 EDK39956.2 - 0.071 12.6 0.1 0.37 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) NOA36 PF06524.7 EDK39956.2 - 0.55 9.4 7.1 0.92 8.7 4.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 EDK39956.2 - 2.8 6.5 14.2 4.8 5.7 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Transp_cyt_pur PF02133.10 EDK39957.2 - 1.6e-53 181.8 36.4 2e-53 181.5 25.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CENP-N PF05238.8 EDK39958.2 - 0.34 9.8 6.2 0.1 11.6 1.7 1.7 1 1 0 2 2 2 0 Kinetochore protein CHL4 like TFIIF_alpha PF05793.7 EDK39958.2 - 1.1 7.5 12.8 1.5 7.1 8.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.5 EDK39958.2 - 2.8 6.9 12.1 3.1 6.7 8.4 1.1 1 0 0 1 1 1 0 BUD22 Ribosomal_60s PF00428.14 EDK39959.1 - 1.9e-21 76.2 15.7 2.4e-21 75.9 10.9 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2637 PF10935.3 EDK39959.1 - 0.024 14.5 2.0 0.028 14.3 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) HemY_N PF07219.8 EDK39959.1 - 4.1 6.9 6.2 4.3 6.9 1.8 2.0 2 0 0 2 2 2 0 HemY protein N-terminus PepSY_2 PF13670.1 EDK39959.1 - 7.9 6.4 10.7 1.6 8.7 4.0 2.0 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain MAM33 PF02330.11 EDK39960.2 - 1.7e-25 89.9 6.5 2.2e-25 89.6 4.5 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein Cyclin_N PF00134.18 EDK39961.2 - 1.3e-43 147.6 0.4 2.3e-43 146.7 0.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 EDK39961.2 - 1.1e-31 109.2 0.0 2.2e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF3844 PF12955.2 EDK39963.2 - 2.2e-31 107.9 5.2 4.1e-31 107.1 3.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Mt_ATP-synt_D PF05873.7 EDK39963.2 - 0.011 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) EGF_2 PF07974.8 EDK39963.2 - 0.92 9.7 12.5 1.7 8.8 8.7 1.5 1 0 0 1 1 1 0 EGF-like domain Evr1_Alr PF04777.8 EDK39964.2 - 3.3e-28 97.4 0.1 5.1e-28 96.8 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family V-SNARE_C PF12352.3 EDK39965.2 - 1.7e-12 47.1 0.2 1.7e-12 47.1 0.2 2.2 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus KxDL PF10241.4 EDK39965.2 - 0.75 9.7 7.8 0.23 11.3 2.0 2.4 2 1 1 3 3 3 0 Uncharacterized conserved protein Sec20 PF03908.8 EDK39965.2 - 0.88 9.3 5.7 2.1 8.1 0.1 2.7 2 1 1 3 3 3 0 Sec20 DUF4570 PF15134.1 EDK39965.2 - 0.89 9.4 11.7 0.24 11.2 0.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4570) DUF1691 PF07950.6 EDK39966.2 - 1.2e-43 147.4 7.4 1.8e-22 79.3 4.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) DUF3816 PF12822.2 EDK39966.2 - 0.059 13.2 0.7 0.11 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) NifU_N PF01592.11 EDK39967.1 - 8.7e-55 184.0 0.1 1.1e-54 183.7 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain LRR_4 PF12799.2 EDK39968.2 - 0.038 13.6 15.7 2.9 7.6 0.1 5.3 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK39968.2 - 0.27 11.4 10.2 7.5 6.9 0.0 5.7 6 0 0 6 6 6 0 Leucine Rich repeat Ribosomal_L18p PF00861.17 EDK39969.1 - 3.3e-43 146.6 0.0 3.3e-43 146.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 EDK39969.1 - 3.6e-32 110.7 7.9 3.6e-32 110.7 5.4 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1160 PF06648.6 EDK39969.1 - 0.05 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) GCR1_C PF12550.3 EDK39969.1 - 0.65 9.9 4.8 5.3 6.9 0.1 2.4 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes SPT6_acidic PF14632.1 EDK39969.1 - 2.1 8.5 8.9 6.5 6.9 6.2 1.8 1 1 0 1 1 1 0 Acidic N-terminal SPT6 NAPRTase PF04095.11 EDK39970.2 - 2.4e-61 207.1 0.2 3.7e-61 206.5 0.1 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family IBN_N PF03810.14 EDK39971.2 - 1.8e-15 56.6 1.4 2.1e-14 53.1 0.0 3.4 5 0 0 5 5 5 1 Importin-beta N-terminal domain CtaG_Cox11 PF04442.9 EDK39972.2 - 4.2e-56 188.9 0.2 6.1e-56 188.4 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Cupredoxin_1 PF13473.1 EDK39972.2 - 0.04 13.7 0.0 0.078 12.8 0.0 1.4 1 0 0 1 1 1 0 Cupredoxin-like domain CPDase PF07823.6 EDK39973.2 - 5.1e-62 208.8 0.0 8.5e-62 208.1 0.0 1.2 1 1 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 EDK39973.2 - 2.8e-05 23.8 0.4 0.0045 16.7 0.4 2.7 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.11 EDK39973.2 - 0.01 15.8 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 LigT like Phosphoesterase PurS PF02700.9 EDK39973.2 - 0.022 14.7 0.6 0.51 10.3 0.0 2.2 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase FHIPEP PF00771.15 EDK39973.2 - 0.15 10.3 0.1 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family Glucosamine_iso PF01182.15 EDK39974.1 - 8.8e-55 185.5 0.0 1e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase NMD3 PF04981.8 EDK39975.2 - 1.5e-74 250.1 4.7 1.5e-74 250.1 3.3 1.6 2 0 0 2 2 2 1 NMD3 family VPS11_C PF12451.3 EDK39975.2 - 0.16 11.8 2.8 0.41 10.5 2.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal HypA PF01155.14 EDK39975.2 - 3.7 7.2 7.0 13 5.5 0.0 2.8 2 1 1 3 3 3 0 Hydrogenase expression/synthesis hypA family Bromodomain PF00439.20 EDK39976.2 - 4.4e-27 93.8 0.4 1e-26 92.6 0.3 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 EDK39976.2 - 1.3e-08 34.9 0.2 2.7e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EDK39976.2 - 3.4e-08 33.3 0.0 6.2e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 EDK39976.2 - 0.0076 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1492 PF07374.6 EDK39976.2 - 0.04 14.0 0.2 0.085 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Daxx PF03344.10 EDK39976.2 - 0.42 9.0 16.4 0.57 8.6 11.3 1.1 1 0 0 1 1 1 0 Daxx Family NOA36 PF06524.7 EDK39976.2 - 0.78 8.9 10.5 1.2 8.2 7.3 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.4 EDK39976.2 - 0.9 8.2 15.8 1.3 7.6 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.9 EDK39976.2 - 1 7.3 12.4 1.5 6.7 8.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.6 EDK39976.2 - 7 6.4 14.0 12 5.7 9.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nop14 PF04147.7 EDK39976.2 - 9.8 3.9 19.5 14 3.4 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2157 PF09925.4 EDK39977.2 - 0.022 14.3 0.3 0.022 14.3 0.2 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF3981 PF13139.1 EDK39977.2 - 0.27 11.2 3.2 0.3 11.0 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) PRT_C PF08372.5 EDK39977.2 - 7.3 6.0 10.2 0.53 9.7 2.1 2.0 1 1 1 2 2 2 0 Plant phosphoribosyltransferase C-terminal TctB PF07331.6 EDK39978.2 - 0.081 12.5 0.3 0.13 11.9 0.2 1.3 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Phage_Coat_Gp8 PF05371.7 EDK39978.2 - 0.39 10.3 5.1 6.9 6.3 0.4 2.5 2 1 0 2 2 2 0 Phage major coat protein, Gp8 ThiF PF00899.16 EDK39979.2 - 8.4e-28 96.8 0.0 2e-27 95.6 0.0 1.7 2 0 0 2 2 2 1 ThiF family 2-Hacid_dh_C PF02826.14 EDK39979.2 - 0.0019 17.4 0.0 0.054 12.6 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EDK39979.2 - 0.0021 18.1 0.0 0.013 15.5 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Spc97_Spc98 PF04130.8 EDK39980.2 - 1e-82 278.2 15.2 1.5e-82 277.6 10.5 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family Proteasome PF00227.21 EDK39981.1 - 6.2e-56 188.6 0.2 8.3e-56 188.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EDK39981.1 - 1.9e-13 49.4 0.1 3.8e-13 48.4 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ATP-grasp_2 PF08442.5 EDK39982.2 - 9.4e-50 168.7 0.8 1.5e-49 168.1 0.6 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 EDK39982.2 - 2.8e-25 88.7 0.0 5e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase AATase PF07247.7 EDK39983.2 - 3.6e-64 217.0 3.4 4.3e-64 216.8 2.3 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EDK39983.2 - 0.00014 20.8 1.3 0.00033 19.6 0.9 1.6 1 1 0 1 1 1 1 Condensation domain DUF947 PF06102.7 EDK39984.2 - 5.1e-49 166.3 26.1 5.1e-49 166.3 18.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF947) Cas_Cas4 PF01930.12 EDK39984.2 - 0.7 9.7 7.0 1.2 9.0 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF83 DUF2507 PF10702.4 EDK39984.2 - 0.71 9.5 4.9 0.43 10.2 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2507) Rhodanese PF00581.15 EDK39986.2 - 2.2e-16 60.2 0.0 3.5e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain FTHFS PF01268.14 EDK39987.1 - 8.4e-262 869.1 0.2 1.1e-261 868.7 0.2 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 EDK39987.1 - 1.8e-65 218.9 0.4 9.9e-65 216.5 0.2 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 EDK39987.1 - 5.3e-38 129.6 0.4 1.2e-37 128.5 0.3 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GTP_EFTU PF00009.22 EDK39987.1 - 0.048 13.0 0.1 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AdoHcyase_NAD PF00670.16 EDK39987.1 - 0.076 12.8 0.2 1.4 8.7 0.1 2.7 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acyl_transf_1 PF00698.16 EDK39988.2 - 5.1e-21 75.3 0.0 6.5e-21 74.9 0.0 1.0 1 0 0 1 1 1 1 Acyl transferase domain HMG_box PF00505.14 EDK39989.1 - 3e-08 33.7 8.7 3e-08 33.7 6.0 2.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EDK39989.1 - 0.00023 21.4 6.8 0.00023 21.4 4.7 2.5 2 0 0 2 2 2 1 HMG-box domain Reo_sigmaC PF04582.7 EDK39989.1 - 0.16 11.1 3.7 0.22 10.6 2.6 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein SDA1 PF05285.7 EDK39990.2 - 1.1e-93 314.0 31.7 1.1e-93 314.0 22.0 2.9 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.7 EDK39990.2 - 5.4e-24 84.2 0.2 1.8e-23 82.5 0.1 2.0 1 0 0 1 1 1 1 NUC130/3NT domain TFIIB PF00382.14 EDK39991.2 - 2e-52 174.8 0.7 2.1e-25 88.3 0.1 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 EDK39991.2 - 9.9e-29 99.4 0.3 9.9e-29 99.4 0.2 2.7 3 0 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 EDK39991.2 - 2.7e-08 32.9 1.5 4.5e-08 32.2 1.0 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 EDK39991.2 - 5.5e-06 25.9 0.1 0.099 12.2 0.0 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain Lar_restr_allev PF14354.1 EDK39991.2 - 0.0092 16.2 0.4 0.022 15.0 0.3 1.6 1 0 0 1 1 1 1 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 EDK39991.2 - 1.1 8.5 3.3 3.6 6.9 2.3 1.9 1 1 0 1 1 1 0 zinc-ribbon domain DUF202 PF02656.10 EDK39992.2 - 9.9e-17 60.9 1.0 9.9e-17 60.9 0.7 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF202) Abhydrolase_9_N PF15420.1 EDK39992.2 - 0.054 13.2 1.6 0.057 13.1 1.1 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus COX4_pro_2 PF07835.7 EDK39992.2 - 0.11 12.5 3.6 0.49 10.4 0.0 2.6 3 0 0 3 3 3 0 Bacterial aa3 type cytochrome c oxidase subunit IV DEAD PF00270.24 EDK39993.2 - 4.6e-42 143.3 0.0 2.3e-41 141.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK39993.2 - 1.8e-28 98.2 0.1 3.4e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK39993.2 - 0.00038 20.3 0.0 0.001 18.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MIF4G_like_2 PF09090.6 EDK39993.2 - 0.047 12.8 0.2 0.14 11.3 0.1 1.7 2 0 0 2 2 2 0 MIF4G like GTP1_OBG PF01018.17 EDK39994.1 - 6.9e-33 113.5 4.6 6.8e-24 84.2 2.5 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 EDK39994.1 - 1.4e-22 79.8 0.0 4e-22 78.3 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK39994.1 - 4.7e-11 42.2 0.0 7e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.17 EDK39994.1 - 2.5e-05 23.7 0.1 5.9e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Ras family Arf PF00025.16 EDK39994.1 - 5.1e-05 22.5 0.0 0.00017 20.8 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 EDK39994.1 - 7e-05 23.2 0.0 0.00017 22.0 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 EDK39994.1 - 0.0002 21.2 0.3 0.23 11.2 0.0 2.9 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 EDK39994.1 - 0.028 13.8 0.0 2.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_21 PF13304.1 EDK39994.1 - 0.03 14.2 0.0 0.07 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK39994.1 - 0.035 13.6 0.0 0.35 10.3 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 EDK39994.1 - 0.057 13.7 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter DUF3602 PF12223.3 EDK39994.1 - 7.8 6.9 8.4 1 9.7 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF3602) Response_reg PF00072.19 EDK39995.1 - 9.7e-16 57.7 0.0 1.4e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Ribonuc_red_lgC PF02867.10 EDK39996.2 - 2e-212 706.5 0.0 2.5e-212 706.2 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 EDK39996.2 - 1.1e-18 66.7 0.2 2.5e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Tfb2 PF03849.9 EDK39997.2 - 6.6e-152 505.3 0.0 1.4e-151 504.3 0.0 1.5 2 0 0 2 2 2 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 EDK39997.2 - 0.00017 21.3 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain STAG PF08514.6 EDK39997.2 - 0.12 12.1 0.2 0.39 10.4 0.0 1.9 2 0 0 2 2 2 0 STAG domain RNA_pol_Rpb2_6 PF00562.23 EDK39998.2 - 6.5e-120 400.4 0.0 6.5e-120 400.4 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 EDK39998.2 - 1.4e-57 193.9 0.6 2.6e-57 193.0 0.4 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 EDK39998.2 - 2e-39 134.9 1.4 4.2e-39 133.9 0.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 EDK39998.2 - 3.9e-30 103.9 0.1 1.1e-29 102.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 EDK39998.2 - 1.9e-26 91.6 0.1 1.5e-25 88.7 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 EDK39998.2 - 7.9e-19 67.1 0.0 1.7e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 EDK39998.2 - 5.3e-12 45.5 0.5 1.7e-11 43.8 0.3 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Baculo_Y142 PF04913.7 EDK39998.2 - 0.00056 18.3 0.1 0.00095 17.6 0.1 1.2 1 0 0 1 1 1 1 Baculovirus Y142 protein zf-RING_2 PF13639.1 EDK39999.2 - 5.3e-11 42.1 6.8 8.9e-11 41.4 4.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK39999.2 - 2e-07 30.8 7.6 3.7e-07 30.0 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK39999.2 - 2e-07 30.9 2.3 4.8e-07 29.7 1.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 EDK39999.2 - 1e-06 28.3 6.7 1.7e-06 27.6 4.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 EDK39999.2 - 1.2e-06 28.0 4.1 2e-06 27.3 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.17 EDK39999.2 - 3.5e-06 26.6 0.0 7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-C3HC4 PF00097.20 EDK39999.2 - 6.5e-06 25.7 6.8 1.1e-05 24.9 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK39999.2 - 0.0019 17.9 1.6 0.0039 17.0 1.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.1 EDK39999.2 - 0.015 15.0 1.8 0.05 13.3 0.2 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-Nse PF11789.3 EDK39999.2 - 0.035 13.6 3.9 0.069 12.6 2.7 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Shisa PF13908.1 EDK39999.2 - 0.1 12.8 0.0 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator zf-RING_UBOX PF13445.1 EDK39999.2 - 0.16 11.7 5.1 0.42 10.3 3.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger RINGv PF12906.2 EDK39999.2 - 0.3 11.1 6.3 0.55 10.3 4.4 1.5 1 0 0 1 1 1 0 RING-variant domain C1_1 PF00130.17 EDK39999.2 - 1.8 8.3 5.2 0.6 9.8 1.5 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FANCL_C PF11793.3 EDK39999.2 - 6.1 6.8 9.4 13 5.8 5.4 2.4 2 1 0 2 2 2 0 FANCL C-terminal domain Zn_clus PF00172.13 EDK40000.2 - 1.7e-05 24.5 6.7 3.5e-05 23.6 4.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mu-like_gpT PF10124.4 EDK40000.2 - 0.024 13.6 0.0 0.072 12.0 0.0 1.7 2 0 0 2 2 2 0 Mu-like prophage major head subunit gpT PAS PF00989.19 EDK40000.2 - 0.097 12.4 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.1 EDK40000.2 - 0.13 12.6 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 PAS domain Noc2 PF03715.8 EDK40001.2 - 2.3e-126 420.7 6.0 2.3e-126 420.7 4.2 1.9 3 0 0 3 3 3 1 Noc2p family DPPIV_N PF00930.16 EDK40002.2 - 3.7e-69 233.0 2.3 5.9e-69 232.3 1.6 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 EDK40002.2 - 3.2e-39 134.3 0.4 5.8e-39 133.5 0.3 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 EDK40002.2 - 1.4e-07 31.3 0.0 3.9e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK40002.2 - 3.9e-05 23.6 0.1 0.0032 17.3 0.0 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1741 PF08427.5 EDK40003.2 - 1.5e-09 37.6 0.1 4.6e-09 36.1 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Mito_carr PF00153.22 EDK40004.2 - 2.2e-64 213.2 1.2 2.1e-22 78.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RIIa PF02197.12 EDK40004.2 - 0.15 11.5 0.0 7.6 6.0 0.0 2.4 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit WD40 PF00400.27 EDK40005.2 - 5.8e-67 219.3 18.2 1.8e-08 33.9 1.1 10.7 10 0 0 10 10 10 9 WD domain, G-beta repeat Kelch_6 PF13964.1 EDK40005.2 - 0.015 15.4 1.2 10 6.5 0.1 3.8 3 0 0 3 3 3 0 Kelch motif DUF792 PF05632.6 EDK40005.2 - 0.058 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) Kelch_1 PF01344.20 EDK40005.2 - 0.072 12.6 0.2 10 5.7 0.1 2.9 2 0 0 2 2 2 0 Kelch motif Gmad1 PF10647.4 EDK40005.2 - 0.45 9.8 3.1 1.5 8.1 0.1 2.9 2 2 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain Med20 PF08612.6 EDK40006.2 - 1.5e-51 174.6 0.0 1.8e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex DEAD PF00270.24 EDK40007.2 - 1.5e-44 151.4 0.1 3e-44 150.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 EDK40007.2 - 3.2e-23 81.0 0.0 7.8e-23 79.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 EDK40007.2 - 1.2e-18 66.7 0.0 2.4e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 EDK40007.2 - 0.00079 19.4 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain RNA_pol_Rpc4 PF05132.9 EDK40008.2 - 3.2e-16 59.5 0.1 3.2e-16 59.5 0.1 4.2 2 2 1 3 3 3 2 RNA polymerase III RPC4 DUF1547 PF07577.6 EDK40008.2 - 0.081 12.6 0.4 13 5.5 0.1 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1547) Sas10 PF09368.5 EDK40009.2 - 1.2e-29 102.2 11.0 1.2e-29 102.2 7.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 EDK40009.2 - 7.8e-08 32.4 1.8 1.8e-07 31.2 0.0 2.5 2 1 1 3 3 3 1 Sas10/Utp3/C1D family Cyclin_N PF00134.18 EDK40010.2 - 8.9e-13 47.9 1.7 1.8e-12 46.9 1.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Borrelia_P83 PF05262.6 EDK40010.2 - 0.0014 17.0 0.2 0.0014 17.0 0.1 1.4 2 0 0 2 2 2 1 Borrelia P83/100 protein Cpn60_TCP1 PF00118.19 EDK40011.2 - 4.6e-139 464.1 14.4 5.2e-139 463.9 10.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family D123 PF07065.9 EDK40012.2 - 4.8e-104 347.6 0.2 5.6e-104 347.4 0.1 1.0 1 0 0 1 1 1 1 D123 SGL PF08450.7 EDK40013.2 - 7.8e-67 225.2 0.1 9.6e-67 224.9 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.11 EDK40013.2 - 0.0051 16.8 0.0 0.016 15.2 0.0 1.8 2 0 0 2 2 2 1 Strictosidine synthase Arylesterase PF01731.15 EDK40013.2 - 0.12 12.3 0.0 0.65 10.0 0.0 2.1 2 0 0 2 2 2 0 Arylesterase zf-HIT PF04438.11 EDK40014.1 - 2e-12 46.5 8.6 2.6e-12 46.1 5.9 1.2 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.13 EDK40014.1 - 0.043 13.6 6.7 0.067 13.0 4.7 1.3 1 0 0 1 1 1 0 MYND finger PolC_DP2 PF03833.8 EDK40014.1 - 0.047 11.3 0.4 0.046 11.4 0.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 MerR-DNA-bind PF09278.6 EDK40014.1 - 0.08 13.3 0.1 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 MerR, DNA binding zf-B_box PF00643.19 EDK40014.1 - 0.33 10.8 7.9 0.47 10.3 5.5 1.2 1 0 0 1 1 1 0 B-box zinc finger Tnp_zf-ribbon_2 PF13842.1 EDK40014.1 - 3.8 7.9 8.5 6.4 7.2 5.9 1.4 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Cyclin_N PF00134.18 EDK40015.2 - 1.6e-05 24.5 0.1 2.2e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EDK40015.2 - 0.00014 22.2 0.1 0.00022 21.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin SHD1 PF03983.7 EDK40015.2 - 0.08 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 SLA1 homology domain 1, SHD1 Frag1 PF10277.4 EDK40016.2 - 2.2e-57 194.0 23.1 2.2e-57 194.0 16.0 1.8 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family VIT1 PF01988.14 EDK40016.2 - 0.055 12.9 1.0 0.12 11.8 0.7 1.7 1 1 0 1 1 1 0 VIT family GWT1 PF06423.7 EDK40016.2 - 1.9 8.5 10.1 0.2 11.7 2.9 2.4 2 2 0 2 2 2 0 GWT1 Fungal_trans PF04082.13 EDK40018.2 - 2.5e-13 49.4 0.7 4.2e-13 48.7 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40018.2 - 1.2e-10 41.1 11.5 1.9e-10 40.4 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.1 EDK40019.2 - 2.9e-10 39.9 18.1 3.4e-06 27.0 3.3 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EDK40019.2 - 2.8e-09 36.7 13.7 0.00012 22.1 1.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK40019.2 - 1.3e-06 28.3 12.2 0.00097 19.3 0.9 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 EDK40019.2 - 0.25 11.4 4.4 0.4 10.8 3.0 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF2225 PF09986.4 EDK40019.2 - 0.29 10.5 0.9 0.68 9.3 0.6 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_jaz PF12171.3 EDK40019.2 - 0.64 10.2 2.7 1 9.6 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Cyclin_N PF00134.18 EDK40020.2 - 2.2e-07 30.4 0.1 3.3e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EDK40020.2 - 0.00013 22.3 0.0 0.00018 21.9 0.0 1.2 1 0 0 1 1 1 1 Cyclin CHZ PF09649.5 EDK40021.1 - 2e-20 71.6 1.7 2e-20 71.6 1.2 2.9 3 1 0 3 3 3 1 Histone chaperone domain CHZ FLO_LFY PF01698.11 EDK40021.1 - 0.87 8.3 9.8 1.3 7.8 6.8 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein NARP1 PF12569.3 EDK40021.1 - 1.6 7.3 10.6 2.2 6.9 7.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Dicty_REP PF05086.7 EDK40021.1 - 5.1 4.7 6.1 5.7 4.5 4.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LSM PF01423.17 EDK40022.1 - 1.3e-15 56.7 0.0 1.8e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF4394 PF14339.1 EDK40022.1 - 0.042 13.1 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) Ras PF00071.17 EDK40024.2 - 1.1e-59 200.4 0.1 1.3e-59 200.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40024.2 - 5.1e-21 75.3 0.0 8.3e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK40024.2 - 3.5e-12 45.9 0.0 4.6e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 EDK40024.2 - 7.6e-07 29.0 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 EDK40024.2 - 0.00066 19.8 0.2 0.047 13.8 0.0 2.1 1 1 1 2 2 2 1 AAA domain GTP_EFTU PF00009.22 EDK40024.2 - 0.00071 19.0 0.0 0.0018 17.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain KAP_NTPase PF07693.9 EDK40024.2 - 0.0019 17.2 0.0 0.0024 16.9 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.1 EDK40024.2 - 0.0026 17.7 0.3 0.0071 16.3 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EDK40024.2 - 0.0058 15.8 0.1 0.013 14.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.7 EDK40024.2 - 0.0097 15.0 0.0 0.014 14.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.22 EDK40024.2 - 0.018 15.3 0.0 0.026 14.8 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_15 PF13175.1 EDK40024.2 - 0.028 13.4 0.0 0.051 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.10 EDK40024.2 - 0.028 14.1 0.1 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 NTPase SRPRB PF09439.5 EDK40024.2 - 0.056 12.6 0.0 0.086 12.0 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 EDK40024.2 - 0.076 12.5 0.0 0.15 11.5 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 EDK40024.2 - 0.14 11.4 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B SPT16 PF08644.6 EDK40025.2 - 1.8e-50 170.7 0.1 1.8e-50 170.7 0.0 2.5 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 EDK40025.2 - 2.6e-36 124.6 0.3 2.6e-36 124.6 0.2 2.3 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 EDK40025.2 - 3.3e-25 88.8 0.0 7e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 EDK40025.2 - 1.8e-18 66.2 0.0 5.5e-18 64.7 0.0 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DNA_primase_lrg PF04104.9 EDK40026.2 - 1.2e-75 254.1 0.0 1.7e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Hydrolase PF00702.21 EDK40027.2 - 2.1e-24 87.1 0.0 6.2e-24 85.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK40027.2 - 4.1e-22 79.2 0.3 8.4e-22 78.2 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 EDK40027.2 - 9.6e-19 67.3 0.0 2.1e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 EDK40027.2 - 3.7e-06 26.7 0.0 9e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 EDK40027.2 - 0.00021 20.9 0.1 0.0017 18.0 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 EDK40027.2 - 0.021 14.1 0.0 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase tRNA-synt_1 PF00133.17 EDK40029.2 - 1.1e-225 750.2 0.1 5.4e-225 747.9 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 EDK40029.2 - 1.7e-38 131.7 0.1 5.8e-38 130.0 0.1 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 EDK40029.2 - 1.8e-19 69.6 0.2 2e-10 39.8 0.0 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 EDK40029.2 - 2.3e-12 46.6 4.9 1.5e-07 30.8 0.0 3.3 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.14 EDK40029.2 - 0.004 16.3 1.4 0.31 10.1 0.0 3.5 4 0 0 4 4 4 1 tRNA synthetases class I (C) catalytic domain DUF848 PF05852.6 EDK40029.2 - 0.012 15.4 6.5 0.18 11.6 1.0 2.7 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) tRNA-synt_1b PF00579.20 EDK40029.2 - 0.5 9.4 0.0 0.5 9.4 0.0 3.3 4 0 0 4 4 4 0 tRNA synthetases class I (W and Y) Prp31_C PF09785.4 EDK40030.2 - 5.6e-29 101.0 9.2 5.6e-29 101.0 6.4 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain Nop PF01798.13 EDK40030.2 - 6.6e-29 100.1 0.0 1.6e-28 98.9 0.0 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 EDK40030.2 - 4.3e-15 55.2 0.3 9.8e-15 54.1 0.2 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain RNase_PH PF01138.16 EDK40031.1 - 1.8e-15 57.4 0.1 2.7e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EDK40031.1 - 0.0003 20.6 0.0 0.00067 19.5 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Pkinase PF00069.20 EDK40032.2 - 1.7e-52 178.1 0.0 1.2e-51 175.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40032.2 - 2.7e-26 92.2 0.0 5.5e-19 68.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EDK40032.2 - 6.5e-06 25.3 0.0 0.0024 16.8 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_C PF00433.19 EDK40032.2 - 1.6e-05 25.3 1.9 7.1e-05 23.2 1.3 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.9 EDK40032.2 - 0.0048 15.9 0.0 0.015 14.3 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK40032.2 - 0.0072 16.0 0.0 0.027 14.2 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Grp1_Fun34_YaaH PF01184.14 EDK40033.2 - 3.6e-90 300.8 22.0 4.3e-90 300.6 15.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3483 PF11982.3 EDK40033.2 - 2.8 7.1 8.3 0.76 9.0 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) CwfJ_C_1 PF04677.10 EDK40034.2 - 1.5e-26 92.4 0.0 4.2e-26 91.0 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 EDK40034.2 - 8.7e-19 67.8 0.7 1.5e-18 67.0 0.5 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 SET PF00856.23 EDK40035.2 - 7.5e-13 49.1 2.0 2.3e-09 37.7 0.0 2.4 2 1 0 2 2 2 2 SET domain zf-FCS PF06467.9 EDK40035.2 - 0.019 14.5 2.9 0.042 13.4 2.0 1.7 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif YHS PF04945.8 EDK40035.2 - 0.022 14.5 1.6 0.095 12.5 0.4 2.5 2 0 0 2 2 2 0 YHS domain DUF4238 PF14022.1 EDK40035.2 - 0.031 13.5 0.4 0.041 13.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) AA_permease PF00324.16 EDK40036.1 - 4.8e-117 391.2 40.7 5.8e-117 390.9 28.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40036.1 - 1.3e-36 126.1 39.2 1.6e-36 125.7 27.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK40037.1 - 2.1e-89 300.0 46.8 2.3e-89 299.9 32.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40037.1 - 2.8e-30 105.2 51.6 3.5e-30 104.9 35.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40038.2 - 7.6e-64 215.8 55.1 9.5e-64 215.4 38.2 1.1 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L21e PF01157.13 EDK40039.1 - 2.5e-42 142.7 6.0 2.5e-42 142.7 4.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.4 EDK40039.1 - 0.00022 20.6 0.0 0.00027 20.3 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 DUF1989 PF09347.5 EDK40039.1 - 0.05 13.0 0.0 0.067 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) Surface_Ag_2 PF01617.12 EDK40039.1 - 0.068 12.3 0.3 0.082 12.1 0.2 1.2 1 0 0 1 1 1 0 Surface antigen CBF PF03914.12 EDK40040.2 - 4.2e-43 146.6 1.1 9.1e-43 145.5 0.8 1.6 1 0 0 1 1 1 1 CBF/Mak21 family MCM PF00493.18 EDK40041.2 - 6.9e-126 419.5 0.9 6.9e-126 419.5 0.6 1.6 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 EDK40041.2 - 3.1e-26 92.2 1.2 1.2e-25 90.3 0.0 2.6 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 EDK40041.2 - 9.8e-08 31.3 0.0 1.7e-06 27.3 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EDK40041.2 - 0.0029 17.2 0.2 0.013 15.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 EDK40041.2 - 0.0034 16.8 0.0 0.016 14.6 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain Methyltransf_15 PF09445.5 EDK40042.2 - 7.3e-47 158.9 0.0 9.6e-47 158.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 EDK40042.2 - 4.7e-08 33.0 0.0 6.7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK40042.2 - 2e-07 31.3 0.0 3.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40042.2 - 1.9e-06 28.3 0.0 3.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 EDK40042.2 - 8.9e-06 25.3 0.0 2.1e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.1 EDK40042.2 - 6.3e-05 22.7 0.0 9.5e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK40042.2 - 0.00099 18.7 0.0 0.0036 16.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 EDK40042.2 - 0.0012 18.0 0.0 0.0021 17.1 0.0 1.4 1 1 0 1 1 1 1 N-6 DNA Methylase MTS PF05175.9 EDK40042.2 - 0.0017 17.7 0.0 0.0076 15.6 0.0 1.8 1 1 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.7 EDK40042.2 - 0.0037 17.7 0.0 0.011 16.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EDK40042.2 - 0.033 13.2 0.1 0.061 12.3 0.0 1.4 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 EDK40042.2 - 0.045 12.8 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF3419 PF11899.3 EDK40042.2 - 0.1 11.3 0.1 2.2 6.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3419) PCMT PF01135.14 EDK40042.2 - 0.14 11.6 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ASFV_L11L PF05293.6 EDK40043.2 - 0.0097 16.0 1.8 0.0098 15.9 0.5 1.5 2 0 0 2 2 2 1 African swine fever virus (ASFV) L11L protein GCR1_C PF12550.3 EDK40044.2 - 5.1e-21 74.3 0.1 9.7e-21 73.4 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes HSP70 PF00012.15 EDK40045.2 - 3.4e-262 870.7 12.7 3.9e-262 870.5 8.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EDK40045.2 - 7.6e-16 57.6 4.0 2.3e-14 52.7 1.1 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 EDK40045.2 - 0.0003 20.4 0.0 0.001 18.7 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EDK40045.2 - 0.011 15.5 9.3 1.1 9.1 2.4 4.0 2 2 0 2 2 2 0 Cell division protein FtsA DUF615 PF04751.9 EDK40045.2 - 0.024 14.2 3.4 0.03 13.9 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF615) Asp PF00026.18 EDK40047.1 - 5.9e-102 341.1 0.1 8.9e-102 340.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK40047.1 - 6e-10 39.3 0.0 1.7e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 EDK40047.1 - 2.9e-05 24.4 0.0 0.02 15.4 0.0 2.6 2 0 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 EDK40047.1 - 0.0012 18.3 0.0 0.011 15.3 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Abhydrolase_6 PF12697.2 EDK40048.2 - 8.7e-13 48.6 0.0 1.2e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK40048.2 - 5.4e-11 42.4 0.0 9.5e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK40048.2 - 1.2e-06 28.3 0.0 3.3e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 EDK40048.2 - 0.00033 20.4 0.0 0.00053 19.7 0.0 1.3 1 0 0 1 1 1 1 Cutinase Abhydrolase_2 PF02230.11 EDK40048.2 - 0.0014 18.1 0.0 0.011 15.1 0.0 2.4 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF676 PF05057.9 EDK40048.2 - 0.007 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 EDK40048.2 - 0.01 15.4 0.0 0.038 13.6 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) PGAP1 PF07819.8 EDK40048.2 - 0.041 13.4 0.0 0.088 12.3 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_9 PF10081.4 EDK40048.2 - 0.069 11.8 0.0 0.2 10.3 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta-hydrolase family UPF0227 PF05728.7 EDK40048.2 - 0.081 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) EamA PF00892.15 EDK40049.2 - 2.7e-25 88.8 30.1 8.7e-15 54.8 3.7 2.7 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.1 EDK40049.2 - 5.2e-07 29.8 6.1 5.2e-07 29.8 4.2 3.3 4 0 0 4 4 4 2 Multidrug resistance efflux transporter Fig1 PF12351.3 EDK40049.2 - 0.037 13.9 0.7 0.037 13.9 0.5 2.3 2 2 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Ras PF00071.17 EDK40050.1 - 8e-51 171.6 0.0 9.1e-51 171.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40050.1 - 6.8e-14 52.3 0.0 9.3e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK40050.1 - 1.8e-09 37.0 0.0 2.4e-09 36.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 EDK40050.1 - 0.00014 21.3 0.0 0.5 9.8 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 EDK40050.1 - 0.026 13.7 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 EDK40050.1 - 0.091 12.7 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NST1 PF13945.1 EDK40051.2 - 4.3e-20 72.5 3.4 2.7e-13 50.4 1.1 4.8 3 1 1 4 4 4 2 Salt tolerance down-regulator Frag1 PF10277.4 EDK40053.2 - 8.8e-23 80.9 23.8 1.1e-22 80.6 16.5 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4131 PF13567.1 EDK40053.2 - 0.018 14.4 0.6 0.018 14.4 0.4 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF4131) Voltage_CLC PF00654.15 EDK40053.2 - 0.056 12.4 14.0 2.2 7.2 0.5 2.1 1 1 1 2 2 2 0 Voltage gated chloride channel Shisa PF13908.1 EDK40053.2 - 0.076 13.1 4.1 4.6 7.3 0.0 3.0 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator UPF0182 PF03699.8 EDK40053.2 - 0.36 8.6 8.2 0.47 8.3 5.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) CobD_Cbib PF03186.8 EDK40053.2 - 2.3 7.2 7.7 1.4 7.9 1.7 2.2 1 1 0 2 2 2 0 CobD/Cbib protein DUF373 PF04123.8 EDK40053.2 - 2.7 6.9 12.0 3.7 6.4 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) SNF2_N PF00176.18 EDK40055.2 - 2e-82 276.3 0.9 3.4e-82 275.6 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 EDK40055.2 - 2.5e-43 146.5 0.8 2.5e-43 146.5 0.6 2.6 3 0 0 3 3 3 1 SLIDE HAND PF09110.6 EDK40055.2 - 1.5e-34 118.7 3.7 1.5e-34 118.7 2.6 3.9 4 1 0 4 4 4 1 HAND Helicase_C PF00271.26 EDK40055.2 - 1.4e-14 53.6 0.0 6.4e-14 51.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK40055.2 - 2.8e-08 33.8 4.1 2.4e-07 30.7 0.0 4.1 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK40055.2 - 5.7e-05 22.6 0.0 0.00014 21.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.1 EDK40055.2 - 0.00043 20.1 0.3 0.1 12.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain DEAD_2 PF06733.10 EDK40055.2 - 0.033 13.5 0.3 0.081 12.3 0.2 1.6 1 0 0 1 1 1 0 DEAD_2 GSHPx PF00255.14 EDK40056.1 - 4e-36 122.6 0.0 5.2e-36 122.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 EDK40056.1 - 0.00041 20.0 0.0 0.0033 17.0 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 EDK40056.1 - 0.0036 16.8 0.1 0.034 13.6 0.1 2.0 1 1 0 1 1 1 1 Redoxin DUF2404 PF10296.4 EDK40057.2 - 2.3e-07 30.8 0.0 1.4e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) Chs3p PF12271.3 EDK40058.1 - 1.6e-136 454.0 21.4 1.9e-136 453.8 14.8 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit FA_desaturase PF00487.19 EDK40058.1 - 0.31 10.4 5.9 0.58 9.5 4.1 1.4 1 0 0 1 1 1 0 Fatty acid desaturase DUF3353 PF11833.3 EDK40058.1 - 6.1 6.2 13.0 0.085 12.2 0.9 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3353) RhoGAP PF00620.22 EDK40059.2 - 1.5e-41 141.5 0.1 4.3e-41 140.0 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.18 EDK40059.2 - 2e-12 47.0 0.8 2e-12 47.0 0.5 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Rsa3 PF14615.1 EDK40059.2 - 0.13 11.5 1.0 19 4.6 0.1 3.0 3 0 0 3 3 3 0 Ribosome-assembly protein 3 COMPASS-Shg1 PF05205.7 EDK40060.2 - 1.9e-33 114.9 1.0 1.9e-33 114.9 0.7 2.0 1 1 1 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 CDC45 PF02724.9 EDK40060.2 - 2.1 6.2 8.4 2.6 5.9 5.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Cullin PF00888.17 EDK40061.2 - 3.2e-56 191.1 17.6 4.7e-56 190.5 12.2 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 EDK40061.2 - 4.4e-12 45.6 5.2 2.7e-10 39.9 0.0 3.8 4 0 0 4 4 4 1 Cullin protein neddylation domain HTH_DeoR PF08220.7 EDK40061.2 - 0.013 15.0 0.0 0.036 13.6 0.0 1.7 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_11 PF08279.7 EDK40061.2 - 0.029 13.9 0.1 0.086 12.4 0.0 1.8 1 0 0 1 1 1 0 HTH domain Rrf2 PF02082.15 EDK40061.2 - 0.056 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator GRIM-19 PF06212.7 EDK40061.2 - 0.13 11.9 0.7 1.5 8.5 0.1 2.4 2 0 0 2 2 2 0 GRIM-19 protein PP-binding PF00550.20 EDK40062.2 - 9.4e-13 48.2 0.5 1.5e-12 47.6 0.3 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 EDK40062.2 - 1.1e-05 25.3 0.4 1.5e-05 24.8 0.3 1.2 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 EDK40062.2 - 0.0011 19.0 0.2 0.0017 18.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1493) Ribosom_S12_S23 PF00164.20 EDK40063.2 - 1e-44 150.8 1.7 1.3e-44 150.5 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Mob_synth_C PF06463.8 EDK40063.2 - 0.056 13.1 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C P34-Arc PF04045.9 EDK40064.2 - 6.7e-108 359.5 1.5 9e-108 359.1 1.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.7 EDK40064.2 - 0.017 14.5 0.7 0.043 13.2 0.5 1.7 1 1 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) CbiK PF06180.6 EDK40064.2 - 0.051 12.6 0.2 0.076 12.0 0.1 1.2 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) Pkinase PF00069.20 EDK40065.2 - 1.1e-55 188.5 0.0 1.5e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40065.2 - 1.1e-38 132.7 0.0 1.6e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40065.2 - 1e-09 37.8 0.0 1.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EDK40065.2 - 0.0003 19.7 0.5 0.00044 19.1 0.3 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Hep_59 PF07052.6 EDK40065.2 - 0.016 15.5 0.2 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Pox_ser-thr_kin PF05445.6 EDK40065.2 - 0.085 11.6 0.3 0.13 11.0 0.2 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ytp1 PF10355.4 EDK40066.2 - 6.1e-108 360.1 9.2 1.1e-107 359.2 6.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 EDK40066.2 - 1.7e-34 117.5 8.4 1.7e-34 117.5 5.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DNA_pol_B PF00136.16 EDK40067.2 - 1.1e-86 291.5 0.0 1.8e-86 290.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 EDK40067.2 - 6.8e-19 67.8 0.5 1.4e-10 40.5 0.1 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 EDK40067.2 - 1.1e-10 41.3 11.5 2.5e-10 40.1 8.0 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RR_TM4-6 PF06459.7 EDK40067.2 - 1.4 8.7 10.4 3.3 7.5 7.2 1.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDP-OH_P_transf PF01066.16 EDK40068.1 - 5e-19 68.4 4.9 5e-19 68.4 3.4 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3643 PF12356.3 EDK40068.1 - 0.015 14.6 0.2 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3643) Apc5 PF12862.2 EDK40069.2 - 1.4e-31 108.1 8.8 2.9e-31 107.1 5.1 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_16 PF13432.1 EDK40069.2 - 0.0003 21.3 0.1 2.2 9.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK40069.2 - 0.0078 15.9 0.5 0.78 9.6 0.1 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 EDK40069.2 - 0.021 14.7 5.1 0.091 12.7 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 EDK40069.2 - 0.023 14.3 0.1 0.023 14.3 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 EDK40069.2 - 0.032 14.8 1.0 7.8 7.4 0.0 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 EDK40069.2 - 0.049 13.4 0.5 0.25 11.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3486 PF11985.3 EDK40069.2 - 0.088 12.8 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) TPR_2 PF07719.12 EDK40069.2 - 0.39 10.7 5.5 1.6 8.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 EDK40069.2 - 2.5 7.7 7.7 0.46 10.1 0.1 3.4 4 1 1 5 5 5 0 TPR repeat RIX1 PF08167.7 EDK40070.2 - 3.6e-45 153.6 0.5 7.3e-44 149.3 0.0 2.8 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis BSP_II PF05432.6 EDK40070.2 - 0.084 12.1 13.3 0.14 11.4 9.2 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Lin-8 PF03353.10 EDK40070.2 - 1.1 8.4 12.2 2 7.6 8.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Merozoite_SPAM PF07133.6 EDK40070.2 - 8.2 6.2 22.2 1.5 8.7 12.6 1.8 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) V_ATPase_I PF01496.14 EDK40071.2 - 5.8e-283 940.4 2.6 6.6e-283 940.2 1.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family U-box PF04564.10 EDK40072.2 - 5.1e-18 64.8 0.3 1.5e-17 63.3 0.0 1.9 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 EDK40072.2 - 0.0092 15.4 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF1451 PF07295.6 EDK40072.2 - 0.067 12.9 0.2 0.27 10.9 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) D5_N PF08706.6 EDK40072.2 - 0.1 12.7 1.4 1.2 9.1 1.0 2.1 1 1 0 1 1 1 0 D5 N terminal like Seryl_tRNA_N PF02403.17 EDK40072.2 - 0.1 12.6 0.7 0.61 10.1 0.3 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Acylphosphatase PF00708.13 EDK40072.2 - 0.11 12.6 0.1 0.2 11.7 0.1 1.4 1 1 0 1 1 1 0 Acylphosphatase IKI3 PF04762.7 EDK40073.2 - 0 1101.0 1.4 0 1100.7 1.0 1.1 1 0 0 1 1 1 1 IKI3 family IF-2B PF01008.12 EDK40073.2 - 0.41 9.5 4.3 3 6.7 0.1 2.8 3 0 0 3 3 3 0 Initiation factor 2 subunit family Rad52_Rad22 PF04098.10 EDK40074.2 - 7.4e-23 80.9 0.1 1e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Uso1_p115_head PF04869.9 EDK40075.2 - 2.6e-116 387.7 0.5 1e-115 385.8 0.4 2.2 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region DUF3584 PF12128.3 EDK40075.2 - 7.4e-05 20.3 254.8 0.0091 13.3 29.2 5.1 1 1 4 5 5 5 4 Protein of unknown function (DUF3584) Snapin_Pallidin PF14712.1 EDK40075.2 - 0.00078 19.7 5.0 0.00078 19.7 3.5 14.9 2 2 15 18 18 14 2 Snapin/Pallidin Myosin_tail_1 PF01576.14 EDK40075.2 - 0.00083 17.2 302.4 0.0018 16.0 29.8 4.5 1 1 2 3 3 3 2 Myosin tail IncA PF04156.9 EDK40075.2 - 0.00093 18.8 282.1 0.4 10.2 23.7 11.9 1 1 10 11 11 11 4 IncA protein Tropomyosin_1 PF12718.2 EDK40075.2 - 0.0025 17.6 45.6 0.0025 17.6 31.6 12.6 2 2 8 11 11 9 4 Tropomyosin like TBPIP PF07106.8 EDK40075.2 - 0.0032 17.0 13.3 0.0032 17.0 9.2 15.9 2 1 16 18 18 15 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4201 PF13870.1 EDK40075.2 - 0.0036 16.7 21.2 0.0036 16.7 14.7 12.1 1 1 9 11 11 9 3 Domain of unknown function (DUF4201) NPV_P10 PF05531.7 EDK40075.2 - 0.0073 16.5 2.1 0.0073 16.5 1.5 15.2 8 6 3 13 13 11 3 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 EDK40075.2 - 0.012 14.7 118.3 0.026 13.7 6.0 9.9 1 1 10 11 11 11 0 Reovirus sigma C capsid protein GAS PF13851.1 EDK40075.2 - 0.023 13.9 293.3 0.3 10.2 27.3 11.2 1 1 10 11 11 11 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 EDK40075.2 - 0.055 11.9 253.3 0.18 10.2 32.5 6.9 1 1 7 8 8 8 0 AAA domain zf-H2C2_2 PF13465.1 EDK40076.2 - 1.7e-06 28.0 0.9 1.7e-06 28.0 0.6 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.21 EDK40076.2 - 0.00012 22.2 15.5 0.0011 19.1 3.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK40076.2 - 0.00032 20.8 14.4 0.082 13.2 2.2 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Optomotor-blind PF11078.3 EDK40076.2 - 0.018 15.4 0.2 0.05 13.9 0.1 1.8 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region RPAP2_Rtr1 PF04181.8 EDK40076.2 - 0.12 12.4 1.4 0.22 11.6 1.0 1.4 1 0 0 1 1 1 0 Rtr1/RPAP2 family zf-met PF12874.2 EDK40076.2 - 0.58 10.4 9.5 3.3 8.0 0.6 2.7 2 1 0 2 2 2 0 Zinc-finger of C2H2 type Fer4_18 PF13746.1 EDK40076.2 - 1.1 9.7 5.5 0.71 10.3 1.1 2.1 1 1 2 3 3 3 0 4Fe-4S dicluster domain PALP PF00291.20 EDK40077.1 - 8.8e-43 146.6 0.0 1.1e-42 146.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Xpo1 PF08389.7 EDK40078.2 - 1.3e-31 109.5 11.5 1.5e-31 109.3 0.0 4.2 5 0 0 5 5 5 2 Exportin 1-like protein WD40 PF00400.27 EDK40079.2 - 2.1e-15 55.9 0.7 0.00067 19.4 0.0 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat PQQ_2 PF13360.1 EDK40079.2 - 0.0048 16.4 1.0 1.8 7.9 0.5 3.1 2 1 0 2 2 2 2 PQQ-like domain Coiled-coil_56 PF09813.4 EDK40080.2 - 0.052 13.5 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 YL1_C PF08265.6 EDK40080.2 - 0.13 11.8 0.1 0.36 10.4 0.1 1.7 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain DUF3453 PF11935.3 EDK40082.2 - 1.5e-61 207.8 0.7 3.3e-61 206.7 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) DSPc PF00782.15 EDK40083.2 - 4.2e-28 97.5 0.2 8.3e-22 77.1 0.0 2.9 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 EDK40083.2 - 8.5e-08 31.8 0.0 3.2e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DUF3548 PF12068.3 EDK40084.2 - 0.088 12.0 0.3 0.19 11.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3548) AAA PF00004.24 EDK40085.2 - 3.6e-15 56.3 0.0 1.3e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 EDK40085.2 - 1e-12 47.9 0.0 4.4e-12 45.9 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 EDK40085.2 - 1e-11 44.6 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.10 EDK40085.2 - 1.8e-10 40.1 0.0 1.2e-06 27.4 0.0 2.2 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 EDK40085.2 - 1.2e-06 28.7 0.0 9.2e-06 25.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EDK40085.2 - 3.1e-06 26.4 0.0 7.3e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 EDK40085.2 - 3.9e-06 26.5 0.0 1.3e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 EDK40085.2 - 2.6e-05 24.2 1.4 0.00074 19.5 0.0 3.0 2 2 0 3 3 3 1 AAA ATPase domain AAA_11 PF13086.1 EDK40085.2 - 4.5e-05 23.1 0.0 7e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.8 EDK40085.2 - 0.00014 21.3 0.0 0.00033 20.1 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_30 PF13604.1 EDK40085.2 - 0.00031 20.3 0.0 0.0028 17.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EDK40085.2 - 0.00054 19.8 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK40085.2 - 0.00087 20.0 0.0 0.0025 18.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 EDK40085.2 - 0.00094 18.4 0.0 0.0066 15.6 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 EDK40085.2 - 0.0017 17.3 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_gamma3 PF12169.3 EDK40085.2 - 0.0031 17.2 0.7 0.0097 15.6 0.2 2.1 2 0 0 2 2 2 1 DNA polymerase III subunits gamma and tau domain III AAA_24 PF13479.1 EDK40085.2 - 0.0056 16.2 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 EDK40085.2 - 0.0063 15.9 0.4 0.04 13.3 0.0 2.3 2 2 0 2 2 2 1 AAA domain TIP49 PF06068.8 EDK40085.2 - 0.017 13.8 0.0 0.57 8.8 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus ResIII PF04851.10 EDK40085.2 - 0.017 14.9 0.0 0.083 12.7 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.22 EDK40085.2 - 0.018 15.3 0.0 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.9 EDK40085.2 - 0.022 14.4 0.3 0.098 12.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Nab2 PF11517.3 EDK40085.2 - 0.024 14.7 0.1 0.066 13.3 0.0 1.7 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) AAA_18 PF13238.1 EDK40085.2 - 0.028 14.7 0.0 0.088 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EDK40085.2 - 0.036 14.0 0.0 0.088 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 EDK40085.2 - 0.044 13.2 0.0 0.14 11.6 0.0 2.0 1 1 0 1 1 1 0 AAA-like domain DUF2075 PF09848.4 EDK40085.2 - 0.045 12.7 0.0 0.08 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.18 EDK40085.2 - 0.048 12.4 0.0 1.9 7.2 0.0 2.2 1 1 0 2 2 2 0 SNF2 family N-terminal domain RNA_helicase PF00910.17 EDK40085.2 - 0.083 13.0 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.13 EDK40085.2 - 0.091 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.1 EDK40085.2 - 0.11 12.8 0.0 0.2 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain BTB_2 PF02214.17 EDK40086.2 - 0.015 15.5 0.0 0.061 13.5 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain KAR9 PF08580.5 EDK40086.2 - 0.09 11.0 1.8 0.12 10.5 1.2 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF3275 PF11679.3 EDK40086.2 - 0.19 11.3 0.4 0.31 10.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Yae1_N PF09811.4 EDK40087.2 - 9.5e-13 47.4 1.5 1.3e-12 47.0 1.1 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal DUF3685 PF12452.3 EDK40088.2 - 0.085 12.0 0.1 0.15 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) DUF1415 PF07209.7 EDK40088.2 - 0.12 12.0 0.3 0.22 11.2 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1415) PX PF00787.19 EDK40089.2 - 0.0089 15.8 0.1 0.029 14.1 0.1 1.9 2 0 0 2 2 2 1 PX domain PAP2 PF01569.16 EDK40090.2 - 9.2e-22 77.0 4.0 9.2e-22 77.0 2.8 1.7 2 0 0 2 2 2 1 PAP2 superfamily DUF4321 PF14209.1 EDK40090.2 - 0.0059 16.2 6.5 0.044 13.4 0.3 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4321) RseC_MucC PF04246.7 EDK40090.2 - 0.018 14.6 0.7 2.7 7.5 0.0 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Colicin_V PF02674.11 EDK40090.2 - 0.036 13.9 9.0 0.15 11.8 3.5 2.9 1 1 1 2 2 2 0 Colicin V production protein MerC PF03203.9 EDK40090.2 - 0.14 12.5 5.5 0.69 10.2 2.4 2.4 1 1 1 2 2 2 0 MerC mercury resistance protein 7TMR-DISM_7TM PF07695.6 EDK40090.2 - 0.2 11.2 17.4 1.9 8.1 1.3 2.5 2 1 0 2 2 2 0 7TM diverse intracellular signalling FUSC_2 PF13515.1 EDK40090.2 - 0.91 9.4 12.4 0.43 10.5 0.7 2.7 2 1 1 3 3 3 0 Fusaric acid resistance protein-like ABC2_membrane_4 PF12730.2 EDK40090.2 - 1.5 7.9 7.3 0.55 9.3 1.5 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein FtsX PF02687.16 EDK40090.2 - 1.5 8.5 12.0 1.4 8.7 0.1 3.6 1 1 1 2 2 2 0 FtsX-like permease family Choline_kinase PF01633.15 EDK40091.2 - 4.1e-42 144.1 0.0 2.6e-41 141.5 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 EDK40091.2 - 7.8e-09 35.6 0.0 2e-08 34.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family HGTP_anticodon2 PF12745.2 EDK40092.2 - 1.3e-93 313.1 1.1 1.3e-93 313.1 0.7 2.4 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 EDK40092.2 - 3.2e-72 242.7 0.7 6.8e-42 143.3 0.0 3.5 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40092.2 - 1.1e-42 145.9 0.2 1.2e-20 73.6 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 EDK40092.2 - 2.3e-18 66.1 0.5 7.5e-18 64.4 0.3 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.1 EDK40092.2 - 6.1e-09 35.3 0.0 1.3e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Histidyl-tRNA synthetase Kinase-like PF14531.1 EDK40092.2 - 4.2e-06 25.9 0.0 0.00031 19.8 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK40092.2 - 0.00022 20.3 0.0 0.18 10.8 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Mre11_DNA_bind PF04152.9 EDK40093.2 - 4.9e-46 156.7 1.2 4.9e-46 156.7 0.8 2.7 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 EDK40093.2 - 5e-28 97.8 0.9 7.8e-28 97.2 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FAM220 PF15487.1 EDK40093.2 - 2.4 7.4 9.7 4.1 6.6 6.7 1.3 1 0 0 1 1 1 0 FAM220 family ATP11 PF06644.6 EDK40094.2 - 7e-86 288.0 11.0 8.3e-86 287.7 7.6 1.0 1 0 0 1 1 1 1 ATP11 protein UvsW PF11637.3 EDK40094.2 - 0.52 10.0 6.2 0.29 10.8 2.3 2.1 1 1 1 2 2 2 0 ATP-dependant DNA helicase UvsW V-ATPase_G PF03179.10 EDK40094.2 - 2.9 8.2 12.0 1.4 9.2 5.1 2.5 1 1 2 3 3 3 0 Vacuolar (H+)-ATPase G subunit zf-DNL PF05180.7 EDK40095.1 - 6.7e-33 112.2 0.7 1.1e-32 111.4 0.5 1.4 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.8 EDK40095.1 - 0.0093 15.6 1.2 0.015 15.0 0.8 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_5 PF13719.1 EDK40095.1 - 0.022 14.3 1.6 1.3 8.6 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain UPF0167 PF03691.9 EDK40095.1 - 0.026 13.9 0.1 0.034 13.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) TFIIS_C PF01096.13 EDK40095.1 - 0.042 13.4 3.8 1.1 8.8 0.6 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_4 PF13717.1 EDK40095.1 - 0.26 11.0 5.5 1.3 8.7 0.1 2.4 1 1 1 2 2 2 0 zinc-ribbon domain zf-C3HC4_3 PF13920.1 EDK40096.2 - 1.4e-05 24.7 7.5 1.4e-05 24.7 5.2 3.6 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) DUF648 PF04890.8 EDK40096.2 - 2.1 7.4 8.8 0.47 9.5 2.1 2.3 2 1 1 3 3 3 0 Family of unknown function (DUF648) PGP_phosphatase PF09419.5 EDK40097.2 - 1.3e-69 232.8 0.1 1.5e-69 232.6 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 EDK40097.2 - 9.6e-07 28.4 0.0 1.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EDK40097.2 - 0.012 16.0 0.0 0.015 15.6 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PI3_PI4_kinase PF00454.22 EDK40098.1 - 3.7e-30 105.1 0.0 6.3e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 EDK40098.1 - 8.7e-10 37.8 0.2 8.7e-10 37.8 0.1 1.9 2 0 0 2 2 2 1 FATC domain HhH-GPD PF00730.20 EDK40098.1 - 0.018 15.2 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein Ependymin PF00811.13 EDK40098.1 - 0.095 12.4 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Ependymin FAT PF02259.18 EDK40100.1 - 1.1e-76 258.1 5.2 1.7e-76 257.4 3.6 1.3 1 0 0 1 1 1 1 FAT domain TPR_11 PF13414.1 EDK40100.1 - 0.11 12.1 0.1 0.11 12.1 0.0 3.3 3 1 0 3 3 3 0 TPR repeat TPR_12 PF13424.1 EDK40100.1 - 0.43 10.5 4.0 3.1 7.7 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 EDK40100.1 - 0.9 9.6 4.0 17 5.6 0.4 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 EDK40100.1 - 2.1 8.3 4.9 23 5.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Med2 PF11214.3 EDK40102.2 - 0.38 10.7 4.8 8.7 6.4 0.0 3.2 3 0 0 3 3 3 0 Mediator complex subunit 2 Acyltransferase PF01553.16 EDK40103.2 - 0.0024 17.3 0.0 0.004 16.5 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Aldo_ket_red PF00248.16 EDK40104.2 - 3.9e-62 209.6 0.1 4.6e-62 209.4 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ABC2_membrane PF01061.19 EDK40105.2 - 7.2e-86 286.6 58.3 4.2e-47 160.0 13.0 3.3 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.7 EDK40105.2 - 3.4e-41 139.0 0.5 2e-34 117.3 0.0 3.3 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 EDK40105.2 - 3.3e-39 134.2 0.0 7.6e-20 71.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter DUF258 PF03193.11 EDK40105.2 - 9e-07 28.2 0.4 3.8e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 EDK40105.2 - 6e-05 22.2 32.5 0.016 14.2 10.2 2.7 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.1 EDK40105.2 - 8e-05 22.1 0.7 0.00046 19.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK40105.2 - 8.6e-05 22.6 0.6 0.00039 20.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 EDK40105.2 - 0.0003 20.2 0.9 0.034 13.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.1 EDK40105.2 - 0.00062 20.5 0.0 0.27 12.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.1 EDK40105.2 - 0.00075 19.4 0.5 0.015 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EDK40105.2 - 0.0015 18.8 0.1 0.12 12.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EDK40105.2 - 0.0017 18.0 0.0 0.55 10.0 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain MMR_HSR1 PF01926.18 EDK40105.2 - 0.0026 17.6 0.0 0.4 10.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.14 EDK40105.2 - 0.0029 16.8 0.0 0.2 10.8 0.0 3.0 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.7 EDK40105.2 - 0.0031 17.2 0.8 0.74 9.4 0.0 3.0 3 0 0 3 3 3 1 NACHT domain AAA_33 PF13671.1 EDK40105.2 - 0.0062 16.4 0.1 0.39 10.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EDK40105.2 - 0.0068 16.7 2.6 0.11 12.8 0.0 3.0 3 1 1 4 4 3 1 AAA domain AAA_22 PF13401.1 EDK40105.2 - 0.007 16.5 0.2 0.51 10.4 0.0 2.9 3 0 0 3 3 2 1 AAA domain cobW PF02492.14 EDK40105.2 - 0.0088 15.5 1.9 0.27 10.6 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.1 EDK40105.2 - 0.0091 15.9 0.0 0.32 10.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 EDK40105.2 - 0.02 13.9 0.0 0.044 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.2 EDK40105.2 - 0.021 14.2 0.9 2.7 7.3 0.1 2.5 2 0 0 2 2 2 0 AAA-like domain Arch_ATPase PF01637.13 EDK40105.2 - 0.071 12.7 0.0 8.6 5.9 0.0 2.5 2 0 0 2 2 2 0 Archaeal ATPase AAA_24 PF13479.1 EDK40105.2 - 0.078 12.5 1.0 6.2 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 EDK40105.2 - 0.082 13.4 0.7 8.9 6.8 0.0 2.9 3 0 0 3 3 2 0 Miro-like protein NTPase_1 PF03266.10 EDK40105.2 - 0.11 12.1 1.0 4.4 6.9 0.1 2.9 3 0 0 3 3 3 0 NTPase AAA_30 PF13604.1 EDK40105.2 - 0.18 11.3 0.2 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EDK40105.2 - 0.29 10.6 0.6 0.65 9.4 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Coprogen_oxidas PF01218.13 EDK40106.2 - 1.7e-131 437.1 0.0 2e-131 436.9 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase CorA PF01544.13 EDK40107.2 - 3.3e-43 147.8 0.4 6.8e-27 94.2 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Tn7_Tnp_TnsA_N PF08722.6 EDK40107.2 - 0.19 11.7 1.5 1.6 8.7 0.1 2.9 3 0 0 3 3 3 0 TnsA endonuclease N terminal DHC_N2 PF08393.8 EDK40108.2 - 7.9e-98 327.6 14.9 7.9e-98 327.6 10.4 4.3 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.7 EDK40108.2 - 2.1e-68 231.1 14.2 2.1e-68 231.1 9.8 4.4 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.2 EDK40108.2 - 3.9e-59 199.9 0.1 9e-59 198.7 0.1 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.10 EDK40108.2 - 1.4e-53 182.0 0.8 4.4e-53 180.4 0.0 2.3 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor MT PF12777.2 EDK40108.2 - 4.1e-31 108.0 5.8 4.3e-30 104.6 3.3 2.3 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 EDK40108.2 - 5.3e-29 100.7 0.0 5.4e-09 35.9 0.0 5.6 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_9 PF12781.2 EDK40108.2 - 7.5e-23 80.5 1.0 2e-22 79.1 0.2 2.1 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.2 EDK40108.2 - 3.7e-22 78.5 0.2 1.2e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 EDK40108.2 - 1.1e-16 60.7 0.0 6.6e-15 54.9 0.0 3.0 3 0 0 3 3 3 1 P-loop containing dynein motor region D3 AAA PF00004.24 EDK40108.2 - 1.4e-11 44.7 0.0 0.0069 16.5 0.0 5.5 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EDK40108.2 - 1.3e-07 32.0 0.0 0.67 10.2 0.0 5.8 5 0 0 5 5 4 2 AAA domain AAA_22 PF13401.1 EDK40108.2 - 1.6e-07 31.5 7.5 0.016 15.3 0.0 7.3 9 0 0 9 9 6 1 AAA domain AAA_17 PF13207.1 EDK40108.2 - 3.2e-07 31.1 0.0 0.97 10.2 0.0 5.5 4 0 0 4 4 4 2 AAA domain AAA_19 PF13245.1 EDK40108.2 - 6e-05 22.7 0.2 1 9.1 0.0 4.4 4 0 0 4 4 4 1 Part of AAA domain AAA_33 PF13671.1 EDK40108.2 - 8e-05 22.5 0.0 0.66 9.8 0.0 4.7 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.7 EDK40108.2 - 0.0027 16.8 0.1 0.43 9.6 0.0 3.5 4 0 0 4 4 4 1 Zeta toxin Mg_chelatase PF01078.16 EDK40108.2 - 0.012 14.7 0.2 1.6 7.8 0.0 3.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 EDK40108.2 - 0.041 13.2 0.3 2 7.7 0.0 3.9 5 0 0 5 5 5 0 AAA domain AAA_28 PF13521.1 EDK40108.2 - 0.083 12.8 0.0 31 4.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain FUSC PF04632.7 EDK40108.2 - 9.5 4.5 1.2 23 3.2 0.8 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ribosomal_S19e PF01090.14 EDK40109.1 - 3.4e-55 185.3 0.1 3.9e-55 185.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF1374 PF07118.6 EDK40110.2 - 0.0027 17.7 0.1 0.022 14.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1374) Med8 PF10232.4 EDK40111.2 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Prefoldin PF02996.12 EDK40112.2 - 7.4e-31 106.2 4.0 8.7e-31 106.0 2.8 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 EDK40112.2 - 0.0028 17.4 7.5 0.015 15.0 0.2 2.2 1 1 1 2 2 2 1 Prefoldin subunit PilJ PF13675.1 EDK40112.2 - 0.0089 16.3 1.9 0.25 11.6 0.4 2.1 1 1 1 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term TAF PF02969.12 EDK40112.2 - 0.1 12.5 0.1 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) Syntaxin-6_N PF09177.6 EDK40112.2 - 0.14 12.5 5.7 0.28 11.6 0.4 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.7 EDK40112.2 - 0.28 10.9 3.3 3.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) End3 PF12761.2 EDK40112.2 - 0.3 10.7 7.2 21 4.7 5.0 2.1 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SlyX PF04102.7 EDK40112.2 - 0.55 10.6 5.2 0.41 11.0 0.2 2.7 2 1 1 3 3 3 0 SlyX IncA PF04156.9 EDK40112.2 - 0.65 9.5 9.6 0.41 10.2 1.0 2.0 2 0 0 2 2 2 0 IncA protein Fzo_mitofusin PF04799.8 EDK40112.2 - 1.4 8.2 5.1 4.2 6.7 0.8 2.1 2 0 0 2 2 2 0 fzo-like conserved region XhlA PF10779.4 EDK40112.2 - 2.3 8.2 8.1 3.9 7.4 0.1 2.4 2 0 0 2 2 2 0 Haemolysin XhlA Noelin-1 PF12308.3 EDK40112.2 - 2.3 8.0 5.0 20 5.0 0.7 2.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein Thi4 PF01946.12 EDK40113.2 - 2.4e-104 347.4 0.0 2.9e-104 347.2 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 EDK40113.2 - 8.7e-09 34.7 0.9 1.2e-07 30.9 0.4 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK40113.2 - 2.5e-07 29.8 2.6 0.00011 21.2 0.7 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 EDK40113.2 - 2.9e-07 30.3 0.1 1.4e-06 28.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EDK40113.2 - 1.3e-06 28.4 0.0 2.2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 EDK40113.2 - 2.5e-06 26.6 0.3 4.9e-06 25.7 0.2 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 EDK40113.2 - 4.3e-05 23.3 0.3 0.00038 20.2 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 EDK40113.2 - 0.00011 22.3 0.0 0.0002 21.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK40113.2 - 0.0033 15.9 0.4 0.0054 15.2 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 EDK40113.2 - 0.0039 16.2 0.1 0.0061 15.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 EDK40113.2 - 0.0067 15.3 0.6 0.019 13.8 0.2 1.8 2 1 1 3 3 3 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 EDK40113.2 - 0.008 15.3 0.1 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 EDK40113.2 - 0.015 13.9 0.3 0.021 13.4 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Shikimate_DH PF01488.15 EDK40113.2 - 0.022 14.8 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UPF0020 PF01170.13 EDK40114.2 - 3.1e-13 49.7 0.0 5.7e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 EDK40114.2 - 2.3e-08 34.0 0.0 5.1e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 EDK40114.2 - 0.00026 20.5 0.1 0.03 13.7 0.1 2.5 2 2 0 2 2 2 1 DNA methylase N6_Mtase PF02384.11 EDK40114.2 - 0.00047 19.3 0.0 0.00085 18.4 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_15 PF09445.5 EDK40114.2 - 0.016 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Met_10 PF02475.11 EDK40114.2 - 0.043 13.4 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein MethyltransfD12 PF02086.10 EDK40114.2 - 0.11 11.8 3.1 0.67 9.3 0.1 2.6 2 1 1 3 3 3 0 D12 class N6 adenine-specific DNA methyltransferase RRM_1 PF00076.17 EDK40115.2 - 7.4e-37 124.8 0.7 4.7e-18 64.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40115.2 - 1.9e-28 98.2 0.3 6.8e-13 48.4 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40115.2 - 6.1e-15 54.8 0.0 1.2e-06 28.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK40115.2 - 0.0052 16.5 0.1 0.29 10.9 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 EDK40115.2 - 0.024 14.3 0.2 0.76 9.5 0.0 2.4 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.6 EDK40115.2 - 0.12 11.8 1.9 11 5.5 0.3 2.7 2 1 0 2 2 2 0 Ribonuclease B OB domain BRF1 PF07741.8 EDK40115.2 - 0.7 10.1 3.1 1.3 9.3 2.2 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain RRM_3 PF08777.6 EDK40115.2 - 0.97 9.3 3.0 4.1 7.3 0.0 2.6 3 0 0 3 3 3 0 RNA binding motif PAT1 PF09770.4 EDK40115.2 - 8.7 4.4 16.9 11 4.0 11.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DEAD PF00270.24 EDK40116.2 - 3.3e-46 156.8 0.1 3.6e-45 153.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DBP10CT PF08147.7 EDK40116.2 - 3e-23 81.3 7.7 1.2e-22 79.4 5.3 2.2 1 0 0 1 1 1 1 DBP10CT (NUC160) domain Helicase_C PF00271.26 EDK40116.2 - 1.7e-20 72.6 0.1 4.8e-20 71.2 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain IMPDH PF00478.20 EDK40117.2 - 6.2e-141 469.3 2.8 7.3e-141 469.1 1.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 EDK40117.2 - 4.8e-14 51.8 0.0 5.1e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 EDK40117.2 - 2e-10 40.3 1.9 1.5e-06 27.5 0.8 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 EDK40117.2 - 5.4e-08 32.0 1.5 2.7e-07 29.7 1.1 2.1 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EDK40117.2 - 3e-05 23.4 0.6 9.7e-05 21.7 0.4 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 EDK40117.2 - 0.00031 19.9 2.3 0.00091 18.3 0.3 2.1 1 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.9 EDK40117.2 - 0.0065 15.4 0.1 0.014 14.4 0.1 1.5 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Aldolase PF01081.14 EDK40117.2 - 0.012 14.7 0.0 0.04 13.0 0.0 1.8 1 0 0 1 1 1 0 KDPG and KHG aldolase B12-binding PF02310.14 EDK40117.2 - 0.044 13.6 0.0 0.092 12.6 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain DUF1273 PF06908.6 EDK40117.2 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1273) Clat_adaptor_s PF01217.15 EDK40118.2 - 1.8e-53 180.0 2.3 2.3e-53 179.7 1.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TraC_F_IV PF11130.3 EDK40118.2 - 0.038 13.4 0.2 0.053 12.9 0.1 1.1 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer Mannosyl_trans3 PF11051.3 EDK40119.2 - 3.5e-88 295.4 0.0 4.8e-88 295.0 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_15 PF01793.11 EDK40120.2 - 1.4e-117 392.3 12.6 1.7e-117 392.1 8.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase IPK PF03770.11 EDK40121.2 - 1.3e-54 184.8 0.0 2.8e-54 183.7 0.0 1.6 2 0 0 2 2 2 1 Inositol polyphosphate kinase HCMVantigenic_N PF12154.3 EDK40121.2 - 0.0056 16.5 1.1 0.0056 16.5 0.7 2.1 2 0 0 2 2 2 1 Glycoprotein B N-terminal antigenic domain of HCMV ADH_N PF08240.7 EDK40122.2 - 1.6e-27 95.4 1.2 1.6e-27 95.4 0.9 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK40122.2 - 1.1e-21 76.7 0.0 1.6e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase F420_oxidored PF03807.12 EDK40122.2 - 0.0099 16.2 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_3 PF13738.1 EDK40122.2 - 0.022 14.8 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Saccharop_dh PF03435.13 EDK40122.2 - 0.036 13.0 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Shikimate_DH PF01488.15 EDK40122.2 - 0.11 12.6 0.1 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FMN_red PF03358.10 EDK40123.2 - 5.9e-12 45.3 0.0 8.9e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 EDK40123.2 - 7.1e-11 42.2 0.1 1.5e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 EDK40123.2 - 3.6e-07 29.8 0.0 5.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.2 EDK40123.2 - 0.0015 18.5 0.0 0.068 13.1 0.0 2.5 2 1 1 3 3 3 1 Flavodoxin domain FMN_red PF03358.10 EDK40124.2 - 8e-12 44.9 0.0 1e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 EDK40124.2 - 1.3e-11 44.6 0.0 2e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 EDK40124.2 - 1.9e-06 27.5 0.0 2.3e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.2 EDK40124.2 - 0.033 14.1 0.0 0.22 11.4 0.0 2.1 2 1 1 3 3 3 0 Flavodoxin domain PNPOx_C PF10590.4 EDK40125.2 - 2.1e-18 65.5 2.1 2.1e-18 65.5 1.4 1.7 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 EDK40125.2 - 2.3e-13 49.9 0.0 3.6e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Cupin_8 PF13621.1 EDK40126.2 - 6.5e-13 48.7 0.0 1.5e-12 47.5 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 EDK40126.2 - 6.4e-09 36.0 0.8 0.00012 22.3 0.1 2.6 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.2 EDK40126.2 - 9.1e-06 25.3 0.0 3.1e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 F-box-like Cupin_2 PF07883.6 EDK40126.2 - 0.044 13.2 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 Cupin domain GPI PF06560.6 EDK40126.2 - 0.057 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Ribosomal_L32p PF01783.18 EDK40127.2 - 1.5e-12 47.4 0.9 1.5e-12 47.4 0.6 2.1 2 0 0 2 2 2 1 Ribosomal L32p protein family Atg14 PF10186.4 EDK40127.2 - 0.086 11.7 0.3 0.14 11.0 0.1 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 zf-ribbon_3 PF13248.1 EDK40127.2 - 0.16 11.2 2.6 0.25 10.5 1.8 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Septin PF00735.13 EDK40128.2 - 5.6e-108 360.2 0.2 6.7e-108 359.9 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EDK40128.2 - 1.7e-09 37.6 0.0 3.2e-09 36.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EDK40128.2 - 4.5e-07 29.1 0.4 1e-06 28.0 0.3 1.8 1 1 0 1 1 1 1 AIG1 family DUF258 PF03193.11 EDK40128.2 - 5.9e-07 28.8 0.0 1.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 EDK40128.2 - 1.3e-05 24.7 0.0 0.00071 19.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 EDK40128.2 - 0.00017 21.4 2.0 0.21 11.3 0.4 2.5 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 EDK40128.2 - 0.0012 19.3 0.1 0.011 16.1 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 EDK40128.2 - 0.0012 18.8 0.2 0.0036 17.3 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain MobB PF03205.9 EDK40128.2 - 0.0026 17.4 0.1 0.14 11.8 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 EDK40128.2 - 0.0036 17.6 0.6 0.0068 16.7 0.4 1.7 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.7 EDK40128.2 - 0.0039 16.3 0.0 0.075 12.1 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_10 PF12846.2 EDK40128.2 - 0.0049 16.3 0.1 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain FtsK_SpoIIIE PF01580.13 EDK40128.2 - 0.0067 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family IIGP PF05049.8 EDK40128.2 - 0.0093 14.8 0.0 0.016 14.0 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) NB-ARC PF00931.17 EDK40128.2 - 0.01 14.7 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.1 EDK40128.2 - 0.015 15.4 0.2 0.048 13.8 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EDK40128.2 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 EDK40128.2 - 0.024 14.1 0.1 0.76 9.2 0.1 2.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 EDK40128.2 - 0.03 13.8 0.1 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 EDK40128.2 - 0.037 13.9 0.2 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 EDK40128.2 - 0.068 12.4 0.3 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B T2SE PF00437.15 EDK40128.2 - 0.073 11.9 0.1 0.13 11.0 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.1 EDK40128.2 - 0.57 11.0 2.1 5.2 7.9 1.5 2.4 1 1 0 1 1 1 0 AAA domain Glyco_transf_8 PF01501.15 EDK40129.2 - 9.2e-37 126.7 0.0 2e-36 125.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 EDK40129.2 - 2.6e-06 27.0 0.0 4.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Myb_DNA-bind_6 PF13921.1 EDK40130.2 - 0.00052 20.0 1.7 0.38 10.8 0.1 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain HTH_7 PF02796.10 EDK40130.2 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MFS_1 PF07690.11 EDK40131.2 - 9.9e-32 110.0 21.4 9.9e-32 110.0 14.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4341 PF14241.1 EDK40131.2 - 0.09 12.4 2.2 0.41 10.3 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4341) FixP_N PF14715.1 EDK40131.2 - 1.4 8.3 8.2 1.4 8.3 0.0 3.4 3 0 0 3 3 3 0 N-terminal domain of cytochrome oxidase-cbb3, FixP ThiF PF00899.16 EDK40132.2 - 9.5e-55 184.1 0.1 6e-34 116.7 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 EDK40132.2 - 3.3e-45 153.2 0.0 6.3e-45 152.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 EDK40132.2 - 3.3e-35 119.4 0.8 4.9e-24 83.6 0.4 2.9 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EDK40132.2 - 1.8e-24 84.8 0.5 6e-20 70.3 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site ABC_membrane PF00664.18 EDK40133.2 - 2e-63 214.4 42.4 2.7e-33 115.5 12.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK40133.2 - 1.8e-56 190.2 0.0 2e-31 109.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EDK40133.2 - 2.9e-15 56.0 0.0 0.00012 21.3 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK40133.2 - 2.2e-11 44.2 0.2 0.21 11.5 0.0 4.3 2 2 2 4 4 4 4 AAA domain AAA_29 PF13555.1 EDK40133.2 - 4e-07 29.4 0.9 0.024 14.1 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 EDK40133.2 - 8.8e-07 28.2 0.1 0.031 13.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 EDK40133.2 - 4.9e-05 24.1 2.4 0.47 11.2 0.2 3.5 3 1 0 3 3 2 2 AAA domain SbcCD_C PF13558.1 EDK40133.2 - 5.7e-05 22.9 0.0 0.4 10.6 0.0 3.5 3 0 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EDK40133.2 - 0.00012 22.3 1.0 2.6 8.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 EDK40133.2 - 0.00018 21.6 1.1 1.5 8.9 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.1 EDK40133.2 - 0.0024 18.2 2.7 0.89 9.8 0.1 2.7 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 EDK40133.2 - 0.0026 17.7 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 EDK40133.2 - 0.004 16.6 7.6 1.1 8.5 0.2 3.6 4 0 0 4 4 3 2 AAA-like domain NB-ARC PF00931.17 EDK40133.2 - 0.0055 15.6 0.3 0.78 8.5 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_25 PF13481.1 EDK40133.2 - 0.0071 15.7 0.1 2.1 7.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.4 EDK40133.2 - 0.0082 14.7 0.1 0.23 9.9 0.0 2.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class RNA_helicase PF00910.17 EDK40133.2 - 0.0092 16.1 0.2 5.2 7.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.18 EDK40133.2 - 0.013 15.4 1.0 0.41 10.6 0.3 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF3987 PF13148.1 EDK40133.2 - 0.021 13.4 0.0 1.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) MobB PF03205.9 EDK40133.2 - 0.026 14.2 1.2 0.41 10.3 0.2 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EDK40133.2 - 0.036 13.9 0.2 7.5 6.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 EDK40133.2 - 0.047 13.5 2.3 0.45 10.2 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_5 PF07728.9 EDK40133.2 - 0.072 12.8 0.3 8.1 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 EDK40133.2 - 0.094 12.3 0.9 13 5.3 0.1 2.6 2 0 0 2 2 2 0 NACHT domain PRK PF00485.13 EDK40133.2 - 0.13 11.8 0.3 8.5 5.8 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Miro PF08477.8 EDK40133.2 - 0.75 10.3 3.0 33 4.9 0.3 3.2 3 0 0 3 3 2 0 Miro-like protein Fungal_trans_2 PF11951.3 EDK40134.2 - 8.5e-11 41.0 0.2 8.5e-11 41.0 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40134.2 - 3.9e-06 26.6 14.4 7.5e-06 25.7 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Brr6_like_C_C PF10104.4 EDK40135.2 - 8.7e-46 154.7 1.6 1.2e-45 154.3 1.1 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF501 PF04417.7 EDK40135.2 - 0.11 12.3 0.0 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF501) UDG PF03167.14 EDK40136.1 - 1.3e-12 47.4 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF913 PF06025.7 EDK40136.1 - 0.048 12.3 0.1 0.074 11.7 0.0 1.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Transposase_22 PF02994.9 EDK40137.2 - 0.004 15.7 2.2 0.0045 15.5 1.6 1.1 1 0 0 1 1 1 1 L1 transposable element MGC-24 PF05283.6 EDK40137.2 - 0.096 12.4 2.3 0.14 11.9 1.6 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Vac_ImportDeg PF09783.4 EDK40139.2 - 4.9e-54 182.5 0.4 6.9e-54 182.0 0.3 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein PEMT PF04191.8 EDK40140.1 - 2.1e-34 117.7 2.9 3.5e-34 117.0 2.0 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase Saccharop_dh PF03435.13 EDK40141.2 - 4.1e-87 292.6 0.0 6.1e-87 292.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Tubulin_3 PF14881.1 EDK40142.2 - 1.4e-24 86.5 0.2 2.6e-24 85.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 EDK40142.2 - 1.2e-17 64.0 0.0 4.8e-17 62.0 0.0 2.1 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 EDK40142.2 - 0.0022 17.8 0.0 0.0046 16.8 0.0 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain DnaJ PF00226.26 EDK40143.2 - 5.6e-27 93.2 2.6 8.3e-27 92.7 1.8 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 EDK40143.2 - 4.4e-13 49.0 16.5 7.3e-13 48.3 11.4 1.4 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 EDK40143.2 - 1.6e-05 24.7 0.1 0.00015 21.5 0.0 2.4 2 0 0 2 2 2 1 DnaJ C terminal domain HypA PF01155.14 EDK40143.2 - 1.3 8.7 5.4 5.9 6.6 0.3 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DZR PF12773.2 EDK40143.2 - 1.8 8.4 11.9 37 4.2 1.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon DUF2408 PF10303.4 EDK40144.2 - 0.059 13.4 0.5 0.59 10.2 0.3 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) HMG_CoA_synt_C PF08540.5 EDK40145.2 - 8e-104 347.0 3.8 1e-103 346.6 2.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 EDK40145.2 - 2e-90 301.0 0.2 3.6e-90 300.1 0.2 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.5 EDK40145.2 - 0.13 11.9 0.2 0.3 10.7 0.1 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ish1 PF10281.4 EDK40146.2 - 1.6e-33 114.3 42.8 3.3e-09 36.6 1.5 8.6 9 0 0 9 9 9 6 Putative stress-responsive nuclear envelope protein HeH PF12949.2 EDK40146.2 - 4.6e-10 38.8 3.2 0.062 12.8 0.0 5.3 5 0 0 5 5 5 3 HeH/LEM domain Apolipoprotein PF01442.13 EDK40146.2 - 0.014 14.9 11.4 0.051 13.0 1.7 3.8 3 1 1 4 4 4 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.8 EDK40146.2 - 0.09 13.1 26.2 3.9 7.9 4.0 6.3 3 1 2 6 6 6 0 Bacterial protein of unknown function (DUF883) Chlorosome_CsmC PF11098.3 EDK40146.2 - 0.85 9.3 9.3 0.18 11.5 2.1 2.8 1 1 1 2 2 2 0 Chlorosome envelope protein C DUF357 PF04010.8 EDK40146.2 - 9.9 5.9 18.9 1.3 8.7 0.7 5.3 5 1 0 5 5 5 0 Protein of unknown function (DUF357) Tubulin_C PF03953.12 EDK40147.1 - 2.6e-49 166.4 0.1 4.1e-49 165.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.20 EDK40147.1 - 6.3e-45 153.6 0.0 9.1e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.1 EDK40147.1 - 0.0077 15.7 0.0 0.037 13.4 0.0 2.1 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.1 EDK40147.1 - 0.045 12.6 0.0 7.1 5.4 0.0 2.2 2 0 0 2 2 2 0 Tubulin like NAD_binding_1 PF00175.16 EDK40148.2 - 3.8e-26 91.7 0.0 5.7e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EDK40148.2 - 2.2e-25 88.6 0.0 3.6e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EDK40148.2 - 2e-05 24.5 0.0 0.0006 19.7 0.0 2.2 1 1 1 2 2 2 1 Ferric reductase NAD binding domain zf-CCCH PF00642.19 EDK40149.2 - 1.6e-09 37.2 11.9 9.1e-05 22.0 1.1 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF2252 PF10009.4 EDK40149.2 - 0.47 9.3 7.9 0.69 8.7 5.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) UPF0560 PF10577.4 EDK40149.2 - 0.93 7.6 12.7 1.6 6.9 8.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Ycf1 PF05758.7 EDK40149.2 - 3.2 5.3 15.1 3.8 5.1 10.5 1.1 1 0 0 1 1 1 0 Ycf1 Cation_efflux PF01545.16 EDK40150.2 - 2.6e-44 151.4 3.4 3.9e-44 150.8 2.4 1.2 1 0 0 1 1 1 1 Cation efflux family CLU PF13236.1 EDK40151.2 - 1.6e-84 282.7 0.0 3.9e-84 281.4 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 EDK40151.2 - 1.2e-37 129.4 2.0 1.2e-35 122.9 1.4 3.1 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.1 EDK40151.2 - 2.7e-21 75.2 3.5 3.8e-09 36.3 0.1 3.5 1 1 4 5 5 5 5 Tetratricopeptide repeat CLU_N PF15044.1 EDK40151.2 - 4.6e-20 71.5 0.4 1.3e-19 70.1 0.3 1.8 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_11 PF13414.1 EDK40151.2 - 1.1e-06 28.2 1.0 0.00023 20.7 0.1 3.7 3 1 2 5 5 5 3 TPR repeat TPR_10 PF13374.1 EDK40151.2 - 4.4e-06 26.4 0.0 0.0082 16.0 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 EDK40151.2 - 1.3e-05 24.7 1.2 0.75 9.8 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK40151.2 - 0.0041 16.6 0.6 12 5.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 EDK40151.2 - 0.14 12.0 0.6 1.1e+02 2.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Nucleoside_tran PF01733.13 EDK40151.2 - 0.15 11.1 0.2 0.29 10.2 0.1 1.4 1 0 0 1 1 1 0 Nucleoside transporter F-box-like PF12937.2 EDK40152.2 - 8.4e-12 44.6 0.0 2e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK40152.2 - 2.4e-09 36.5 1.4 3.1e-09 36.2 0.1 1.9 2 0 0 2 2 2 1 F-box domain RAB3GAP2_N PF14655.1 EDK40152.2 - 0.04 12.9 0.0 0.074 12.0 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3760 PF12586.3 EDK40152.2 - 0.097 12.5 0.0 13 5.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) RPM2 PF08579.6 EDK40153.2 - 4.7e-30 104.1 1.4 4.7e-30 104.1 1.0 3.5 3 0 0 3 3 3 1 Mitochondrial ribonuclease P subunit (RPM2) Methyltransf_11 PF08241.7 EDK40154.2 - 8.9e-15 54.9 0.0 1.5e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK40154.2 - 4.2e-10 39.1 0.0 6.2e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 EDK40154.2 - 2.4e-09 37.1 0.0 3.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK40154.2 - 1.9e-08 34.0 0.0 2.5e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40154.2 - 4.9e-08 33.5 0.0 8.2e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK40154.2 - 5.4e-07 30.0 0.0 9.4e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK40154.2 - 8.2e-07 29.3 0.0 1.5e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 EDK40154.2 - 0.00017 20.6 0.0 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.7 EDK40154.2 - 0.00019 20.8 0.0 0.0003 20.1 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_26 PF13659.1 EDK40154.2 - 0.0004 20.3 0.0 0.001 19.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 EDK40154.2 - 0.002 17.8 0.0 0.003 17.2 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 EDK40154.2 - 0.019 14.3 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DNA_methylase PF00145.12 EDK40154.2 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Mannosyl_trans3 PF11051.3 EDK40155.2 - 2.5e-68 230.3 0.1 5.3e-68 229.3 0.0 1.6 2 0 0 2 2 2 1 Mannosyltransferase putative YchF-GTPase_C PF06071.8 EDK40157.1 - 7.8e-36 121.7 0.2 1.4e-35 120.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF933) TGS PF02824.16 EDK40157.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 TGS domain SecA_PP_bind PF01043.15 EDK40157.1 - 0.035 14.4 0.3 0.066 13.5 0.1 1.6 2 0 0 2 2 2 0 SecA preprotein cross-linking domain MMR_HSR1 PF01926.18 EDK40158.1 - 1.2e-13 51.0 0.0 2.5e-13 49.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK40158.1 - 0.0021 17.3 0.0 0.004 16.4 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EDK40158.1 - 0.046 13.5 0.1 1.6 8.5 0.0 2.5 3 0 0 3 3 3 0 Dynamin family AAA_23 PF13476.1 EDK40158.1 - 0.048 13.9 1.8 0.17 12.1 1.2 1.8 1 1 0 1 1 1 0 AAA domain Ribosomal_L37 PF08561.5 EDK40159.1 - 1.5e-25 88.5 1.8 1.7e-25 88.3 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 TnpV PF14198.1 EDK40159.1 - 0.047 13.5 0.3 0.067 13.0 0.2 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV EXS PF03124.9 EDK40160.2 - 0.074 12.0 0.6 0.089 11.7 0.4 1.1 1 0 0 1 1 1 0 EXS family Asp PF00026.18 EDK40161.2 - 1.2e-48 165.9 4.5 1.6e-48 165.5 3.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK40161.2 - 7.3e-12 45.5 0.0 1.3e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal DIL PF01843.14 EDK40162.2 - 2.5e-16 59.4 8.7 2.9e-12 46.3 0.1 3.4 3 1 1 4 4 4 2 DIL domain Ank PF00023.25 EDK40162.2 - 1.3e-10 40.4 0.0 0.00075 19.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 EDK40162.2 - 3.4e-09 36.6 0.1 0.00077 19.6 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 EDK40162.2 - 5e-09 36.3 0.0 1.9e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 EDK40162.2 - 8.9e-07 28.5 0.0 0.021 15.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 EDK40162.2 - 0.0015 18.9 0.0 0.19 12.3 0.0 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) CIMR PF00878.13 EDK40163.2 - 1.2e-10 41.3 0.1 4.2e-05 23.3 0.1 2.5 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.10 EDK40163.2 - 2e-08 33.6 0.0 3.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.1 EDK40163.2 - 0.0052 16.2 0.0 0.011 15.1 0.0 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein NADH5_C PF06455.6 EDK40163.2 - 0.11 11.8 0.2 0.19 11.1 0.0 1.4 2 0 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus MTP18 PF10558.4 EDK40164.2 - 4.1e-65 218.2 0.1 6.7e-65 217.5 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF2407_C PF13373.1 EDK40165.2 - 9.4e-40 135.7 0.0 1.4e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 EDK40165.2 - 2.9e-18 65.8 0.0 5.6e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.18 EDK40165.2 - 0.12 11.8 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family 3-HAO PF06052.7 EDK40166.2 - 7.2e-66 220.2 0.0 8e-66 220.0 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 EDK40166.2 - 1.5e-06 27.5 0.0 2.5e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 EDK40166.2 - 0.029 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_3 PF05899.7 EDK40166.2 - 0.1 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) UDPGP PF01704.13 EDK40169.2 - 5.3e-118 394.1 0.0 6.5e-118 393.8 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Gp-FAR-1 PF05823.7 EDK40169.2 - 0.086 12.7 0.1 0.27 11.1 0.0 1.9 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Complex1_49kDa PF00346.14 EDK40171.1 - 5.3e-129 429.0 0.0 6.6e-129 428.6 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.14 EDK40171.1 - 0.18 10.5 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase DnaJ PF00226.26 EDK40172.2 - 7.5e-19 67.2 2.4 2.1e-18 65.8 1.7 1.8 1 0 0 1 1 1 1 DnaJ domain Trigger_C PF05698.9 EDK40172.2 - 0.0064 16.3 0.1 0.018 14.8 0.0 1.7 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus DUF2076 PF09849.4 EDK40173.1 - 1.5e-07 31.7 4.3 1.6e-07 31.6 3.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 EDK40173.1 - 6.8e-05 22.6 4.0 0.00011 21.9 2.8 1.4 1 0 0 1 1 1 1 CHCH domain Gly-zipper_OmpA PF13436.1 EDK40173.1 - 0.0056 16.3 3.6 0.01 15.4 2.5 1.5 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain Nucleoporin_FG PF13634.1 EDK40173.1 - 0.043 14.0 8.4 0.067 13.4 5.8 1.4 1 0 0 1 1 1 0 Nucleoporin FG repeat region COX6B PF02297.12 EDK40173.1 - 0.4 10.7 6.5 0.63 10.1 4.5 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Na_K-ATPase PF00287.13 EDK40173.1 - 0.56 8.9 3.7 0.69 8.6 2.6 1.1 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain DUF3235 PF11574.3 EDK40173.1 - 1 9.6 4.9 0.7 10.1 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Sec-ASP3 PF15432.1 EDK40175.2 - 0.023 14.6 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 Attacin_C PF03769.10 EDK40176.2 - 0.0095 16.0 0.9 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 Attacin, C-terminal region RAP1 PF07218.6 EDK40176.2 - 0.87 7.6 4.3 1.4 6.9 3.0 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Topoisom_I_N PF02919.10 EDK40177.2 - 1.6e-102 341.3 4.2 1.6e-102 341.3 2.9 2.6 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 EDK40177.2 - 3.7e-81 271.6 0.4 3.7e-81 271.6 0.3 2.2 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 EDK40177.2 - 3.4e-31 106.7 0.2 1.1e-30 105.1 0.2 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF3610 PF12272.3 EDK40177.2 - 0.012 15.2 0.9 0.96 9.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3610) PIN_4 PF13638.1 EDK40177.2 - 0.1 12.7 4.5 0.5 10.4 3.1 2.1 1 0 0 1 1 1 0 PIN domain Herpes_LP PF03363.8 EDK40177.2 - 0.14 11.6 2.0 0.3 10.6 1.4 1.4 1 0 0 1 1 1 0 Herpesvirus leader protein Pkinase PF00069.20 EDK40178.2 - 2.4e-71 239.9 0.0 4e-71 239.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40178.2 - 2e-38 131.9 0.0 3.2e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.13 EDK40178.2 - 4.2e-31 106.7 4.5 2.9e-16 59.1 0.0 3.0 3 0 0 3 3 3 2 POLO box duplicated region Kinase-like PF14531.1 EDK40178.2 - 2.9e-10 39.6 0.0 1.4e-09 37.3 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK40178.2 - 0.0027 16.8 0.0 0.0063 15.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK40178.2 - 0.086 12.5 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Aminotran_5 PF00266.14 EDK40179.2 - 1.2e-78 264.4 0.0 1.6e-78 264.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 EDK40179.2 - 4.9e-08 32.4 0.0 6e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EDK40179.2 - 1.8e-05 23.9 0.1 2.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 EDK40179.2 - 8.4e-05 21.1 0.0 0.00012 20.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Iso_dh PF00180.15 EDK40180.2 - 7e-130 433.0 0.0 8.1e-130 432.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3507 PF12015.3 EDK40181.2 - 1.3e-65 220.3 0.0 3.2e-65 219.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF2015 PF09435.5 EDK40182.2 - 8.7e-41 138.6 0.4 1.1e-40 138.3 0.3 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF3290 PF11694.3 EDK40182.2 - 0.031 13.9 1.0 0.046 13.4 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Endonuc-dimeris PF09124.5 EDK40182.2 - 0.046 13.3 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation RRM_1 PF00076.17 EDK40183.2 - 4e-42 141.7 0.8 1.4e-18 66.2 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40183.2 - 1.3e-32 111.6 0.1 3e-13 49.5 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40183.2 - 8.4e-19 67.1 0.0 6.3e-09 35.5 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 EDK40183.2 - 7.9e-07 28.7 1.1 0.2 11.4 0.2 3.4 3 1 0 3 3 3 3 Limkain b1 DUF1325 PF07039.6 EDK40184.2 - 4.8e-32 110.2 0.0 7.5e-32 109.6 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4537 PF15057.1 EDK40184.2 - 0.036 13.8 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) ER_lumen_recept PF00810.13 EDK40185.2 - 1.6e-06 28.7 8.2 1.2e-05 25.8 4.7 2.2 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.9 EDK40185.2 - 0.00024 20.5 7.9 0.0016 17.9 0.1 2.8 2 0 0 2 2 2 2 PQ loop repeat PgaD PF13994.1 EDK40185.2 - 0.16 11.4 3.2 0.14 11.6 0.2 2.2 2 0 0 2 2 2 0 PgaD-like protein PLDc_2 PF13091.1 EDK40186.2 - 5.9e-14 51.9 0.0 4.9e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 EDK40186.2 - 4.2e-06 26.3 1.7 0.13 12.0 0.1 3.9 3 1 0 3 3 3 2 Phospholipase D Active site motif YchF-GTPase_C PF06071.8 EDK40187.2 - 1.6e-27 95.1 0.1 6.1e-27 93.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 EDK40187.2 - 1.4e-15 57.2 0.7 2e-14 53.5 0.3 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.16 EDK40187.2 - 3e-06 26.9 0.0 5.7e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 EDK40187.2 - 0.0006 19.1 0.0 0.0014 17.9 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_14 PF13173.1 EDK40187.2 - 0.0022 17.8 0.0 0.015 15.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.1 EDK40187.2 - 0.0027 18.0 0.5 0.0046 17.2 0.4 1.4 1 0 0 1 1 1 1 AAA domain COG5 PF10392.4 EDK40187.2 - 0.0053 16.7 1.5 0.04 13.8 0.1 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 DUF3236 PF11576.3 EDK40187.2 - 0.087 12.2 0.0 0.22 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) MFS_1 PF07690.11 EDK40188.2 - 6.2e-34 117.2 49.3 4.4e-33 114.4 33.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK40188.2 - 5.7e-10 38.3 28.7 9.9e-10 37.5 19.8 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter UPF0154 PF03672.8 EDK40188.2 - 0.068 12.7 0.3 0.14 11.7 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Ribosomal_L27 PF01016.14 EDK40189.1 - 2.8e-32 110.3 0.1 5.1e-32 109.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein GvpL_GvpF PF06386.6 EDK40189.1 - 0.16 11.4 10.7 0.067 12.7 5.7 1.6 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF2058 PF09831.4 EDK40189.1 - 0.81 9.5 8.8 0.11 12.3 2.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Rer1 PF03248.8 EDK40190.2 - 9.7e-82 272.8 7.0 1.1e-81 272.6 4.8 1.0 1 0 0 1 1 1 1 Rer1 family MFS_1 PF07690.11 EDK40190.2 - 0.0025 16.5 2.3 0.0034 16.1 1.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Ndc1_Nup PF09531.5 EDK40190.2 - 0.012 14.0 7.0 0.41 8.9 1.1 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Pox_P35 PF03213.9 EDK40190.2 - 0.21 10.5 1.4 0.3 10.0 1.0 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein DUF1538 PF07556.6 EDK40190.2 - 0.31 10.0 3.2 0.59 9.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1538) ANTH PF07651.11 EDK40191.2 - 2.7e-77 259.2 0.0 2.7e-77 259.2 0.0 4.3 2 1 1 3 3 3 1 ANTH domain I_LWEQ PF01608.12 EDK40191.2 - 9.5e-66 220.4 5.1 9.5e-66 220.4 3.5 7.1 5 1 2 7 7 7 3 I/LWEQ domain AA_permease PF00324.16 EDK40192.2 - 3.4e-76 256.5 16.9 3.7e-76 256.4 11.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40192.2 - 7.7e-28 97.1 20.4 1e-27 96.7 14.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK40193.2 - 2.2e-27 95.5 17.8 2.4e-27 95.4 12.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40193.2 - 3.2e-08 32.5 15.9 3.4e-08 32.4 11.0 1.0 1 0 0 1 1 1 1 Amino acid permease NAD_binding_10 PF13460.1 EDK40194.2 - 1.8e-05 24.8 0.0 2.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_7 PF13241.1 EDK40194.2 - 0.00015 21.9 0.0 0.00025 21.2 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding adh_short PF00106.20 EDK40194.2 - 0.00024 21.0 1.0 0.00056 19.8 0.7 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 EDK40194.2 - 0.00081 18.8 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 EDK40194.2 - 0.0012 17.9 0.0 0.0024 16.9 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain KR PF08659.5 EDK40194.2 - 0.0016 18.1 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.19 EDK40194.2 - 0.0024 18.1 0.0 0.0074 16.5 0.0 1.8 3 0 0 3 3 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.8 EDK40194.2 - 0.0037 16.5 0.6 0.006 15.8 0.4 1.4 1 1 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.15 EDK40194.2 - 0.012 15.6 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EDK40194.2 - 0.015 14.9 0.1 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 EDK40194.2 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.14 EDK40194.2 - 0.039 13.0 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EDK40194.2 - 0.054 12.2 0.1 0.082 11.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family UEV PF05743.8 EDK40195.2 - 2.2e-24 85.4 0.4 3.8e-24 84.7 0.0 1.7 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.5 EDK40195.2 - 0.00065 19.2 0.0 0.0017 17.9 0.0 1.8 1 0 0 1 1 1 1 Vps23 core domain Flagellin_C PF00700.16 EDK40195.2 - 0.12 12.4 0.8 0.24 11.5 0.3 1.7 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region DKCLD PF08068.7 EDK40196.2 - 8.5e-30 102.4 0.1 4e-29 100.3 0.1 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 EDK40196.2 - 4.4e-21 75.5 5.7 1e-19 71.1 0.0 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 EDK40196.2 - 2.3e-20 72.1 0.6 4.5e-20 71.1 0.4 1.5 1 0 0 1 1 1 1 PUA domain GAGA_bind PF06217.7 EDK40196.2 - 1.6 8.6 17.0 2.3 8.1 11.8 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Cohesin_load PF10345.4 EDK40197.2 - 2.1e-46 158.3 16.6 2.5e-46 158.1 11.5 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.1 EDK40197.2 - 0.06 13.2 0.9 1.4 8.9 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat NPV_P10 PF05531.7 EDK40198.2 - 1.6 8.9 6.6 1.9 8.7 0.1 3.4 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Exo_endo_phos PF03372.18 EDK40199.2 - 4.2e-15 56.3 0.0 6.6e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EDK40199.2 - 8.5e-12 44.7 0.0 6.4e-10 38.6 0.0 2.8 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 EDK40199.2 - 6e-11 42.0 2.8 1.3e-10 40.9 1.9 1.6 1 0 0 1 1 1 1 GRF zinc finger TBP PF00352.16 EDK40200.1 - 2.6e-69 228.6 0.1 3e-34 116.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 EDK40200.1 - 0.0016 18.4 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4116 PF13475.1 EDK40201.2 - 0.067 12.6 0.1 0.4 10.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) BAR PF03114.13 EDK40202.1 - 7.7e-54 182.6 1.0 8.8e-54 182.4 0.7 1.0 1 0 0 1 1 1 1 BAR domain PRD PF00874.15 EDK40202.1 - 0.09 12.9 0.4 0.33 11.1 0.2 2.0 2 1 0 2 2 2 0 PRD domain DUF2303 PF10065.4 EDK40202.1 - 0.095 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) Actin PF00022.14 EDK40204.2 - 6e-13 47.9 0.0 8.6e-07 27.7 0.0 2.7 1 1 1 2 2 2 2 Actin DUF4206 PF13901.1 EDK40204.2 - 0.024 14.2 0.4 0.039 13.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) DUF1227 PF06777.6 EDK40205.2 - 4.5e-62 208.0 0.5 1e-61 206.9 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 EDK40205.2 - 9.5e-52 174.9 1.9 1.9e-51 173.8 1.3 1.6 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 EDK40205.2 - 1.9e-43 148.3 0.0 4.8e-43 147.0 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.24 EDK40205.2 - 0.00061 19.3 0.1 0.14 11.6 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 EDK40205.2 - 0.0067 16.2 0.5 1.7 8.4 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit SNF2_N PF00176.18 EDK40205.2 - 0.0094 14.7 0.1 1.1 8.0 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain ADK PF00406.17 EDK40206.2 - 6.2e-43 146.2 0.0 7.8e-43 145.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 EDK40206.2 - 1.7e-12 46.7 0.0 3.1e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 EDK40206.2 - 3.8e-05 23.9 0.0 9.6e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EDK40206.2 - 0.00018 22.2 0.0 0.00055 20.7 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 EDK40206.2 - 0.00023 21.0 0.1 0.00051 19.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain Guanylate_kin PF00625.16 EDK40206.2 - 0.11 11.9 0.0 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase Leo1 PF04004.8 EDK40207.2 - 2.1e-42 144.7 1.3 2.1e-42 144.7 0.9 2.3 3 0 0 3 3 3 1 Leo1-like protein HUN PF08729.5 EDK40207.2 - 0.027 14.3 10.3 0.027 14.3 7.2 3.1 2 0 0 2 2 2 0 HPC2 and ubinuclein domain RhoGAP PF00620.22 EDK40208.2 - 6.2e-36 123.2 0.4 7.3e-20 71.1 0.0 2.7 3 0 0 3 3 3 2 RhoGAP domain BAR PF03114.13 EDK40209.2 - 2.6e-58 197.2 8.0 3.4e-58 196.8 5.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 EDK40209.2 - 3.6e-15 55.0 0.0 7.8e-15 53.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK40209.2 - 4.6e-15 54.9 0.1 7.9e-15 54.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK40209.2 - 9.3e-11 41.0 0.0 1.9e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF605 PF04652.11 EDK40209.2 - 0.0066 15.8 14.4 0.011 15.1 10.0 1.3 1 0 0 1 1 1 1 Vta1 like peroxidase PF00141.18 EDK40210.2 - 1.5e-47 162.0 0.0 2.2e-47 161.4 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Microcephalin PF12258.3 EDK40210.2 - 0.16 10.9 2.1 0.22 10.4 1.5 1.1 1 0 0 1 1 1 0 Microcephalin protein IDO PF01231.13 EDK40211.2 - 8.6e-161 535.0 0.0 9.7e-161 534.9 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase tRNA-synt_His PF13393.1 EDK40212.2 - 4.5e-41 140.8 0.1 2.7e-34 118.6 0.0 2.2 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 EDK40212.2 - 3.9e-19 68.8 0.0 7.7e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EDK40212.2 - 6.6e-12 45.2 0.7 1.4e-11 44.1 0.1 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2 PF00152.15 EDK40212.2 - 3.1e-05 22.9 0.1 0.00035 19.4 0.1 2.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) HGTP_anticodon2 PF12745.2 EDK40212.2 - 0.019 14.0 0.2 0.019 14.0 0.1 2.4 3 0 0 3 3 3 0 Anticodon binding domain of tRNAs tRNA-synt_2d PF01409.15 EDK40212.2 - 0.05 12.7 0.0 0.081 12.0 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Ribosomal_60s PF00428.14 EDK40212.2 - 0.81 10.1 13.6 0.92 9.9 0.2 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein FA_desaturase PF00487.19 EDK40213.2 - 2.3e-30 105.8 10.5 2.3e-30 105.8 7.3 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.5 EDK40213.2 - 3e-17 61.5 0.3 6.8e-17 60.4 0.2 1.7 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) EST1_DNA_bind PF10373.4 EDK40214.2 - 9.3e-40 136.5 5.4 9.3e-40 136.5 3.8 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.4 EDK40214.2 - 8.1e-23 80.8 4.3 8.1e-23 80.8 3.0 2.6 3 0 0 3 3 3 1 Telomerase activating protein Est1 Peptidase_C97 PF05903.9 EDK40215.1 - 6.6e-38 129.8 0.0 7.3e-38 129.7 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 EDK40215.1 - 0.021 14.7 0.8 0.069 13.1 0.5 1.9 1 1 0 1 1 1 0 Lecithin retinol acyltransferase WEMBL PF05701.6 EDK40216.2 - 0.0015 17.0 2.9 0.0021 16.5 2.0 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light Med28 PF11594.3 EDK40216.2 - 0.062 13.5 5.2 0.23 11.7 3.5 2.0 1 1 0 1 1 1 0 Mediator complex subunit 28 Sec2p PF06428.6 EDK40216.2 - 0.076 12.8 3.9 0.11 12.3 1.1 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p BRX_N PF13713.1 EDK40216.2 - 0.12 11.8 1.0 0.31 10.5 0.7 1.7 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain CENP-H PF05837.7 EDK40216.2 - 0.92 9.7 7.5 0.14 12.3 2.2 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Actin PF00022.14 EDK40217.2 - 3.5e-72 243.0 0.0 8e-72 241.8 0.0 1.6 1 1 0 1 1 1 1 Actin ECH_C PF13766.1 EDK40218.2 - 9.2e-32 109.6 0.2 2.1e-31 108.5 0.2 1.7 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 EDK40218.2 - 7.2e-25 87.5 0.0 3.1e-24 85.4 0.0 1.9 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase family WD40 PF00400.27 EDK40219.2 - 8.1e-07 28.6 1.7 0.013 15.3 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Lactonase PF10282.4 EDK40219.2 - 0.018 14.1 0.0 1.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Sec62 PF03839.11 EDK40220.2 - 6.3e-57 192.5 2.3 8.2e-57 192.2 1.6 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 Arrestin_C PF02752.17 EDK40221.2 - 9.5e-24 84.0 0.0 6.3e-21 74.9 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 EDK40221.2 - 2.9e-08 33.6 0.1 8e-07 28.9 0.0 2.9 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Abhydrolase_6 PF12697.2 EDK40222.2 - 9.6e-16 58.3 0.0 1.4e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK40222.2 - 2.3e-14 53.5 0.0 3.9e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK40222.2 - 3.6e-05 23.5 0.0 7.7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 EDK40222.2 - 0.0065 16.2 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Cutinase Lipase_3 PF01764.20 EDK40222.2 - 0.026 14.1 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Glyco_transf_20 PF00982.16 EDK40223.2 - 1.9e-150 501.5 0.0 2.3e-150 501.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 EDK40223.2 - 5.3e-78 261.1 0.0 9.8e-78 260.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.15 EDK40223.2 - 0.0061 16.0 0.0 0.048 13.0 0.0 2.3 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EDK40223.2 - 0.0061 16.7 0.1 0.022 14.9 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Hydrolase_3 PF08282.7 EDK40223.2 - 0.018 14.6 0.0 0.14 11.7 0.0 2.0 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase RRM_1 PF00076.17 EDK40224.2 - 9.7e-87 284.6 3.4 2e-21 75.4 0.2 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40224.2 - 2.6e-60 200.3 0.5 2.8e-17 62.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40224.2 - 2.1e-41 139.5 0.1 2.4e-09 36.8 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 EDK40224.2 - 1.9e-25 88.3 0.3 1.9e-25 88.3 0.2 2.8 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain Limkain-b1 PF11608.3 EDK40224.2 - 6.9e-05 22.5 2.2 0.023 14.4 0.1 3.5 3 0 0 3 3 3 1 Limkain b1 Calcipressin PF04847.7 EDK40224.2 - 0.00021 20.8 1.5 0.46 10.0 0.1 4.0 4 0 0 4 4 4 1 Calcipressin CbiG_mid PF11761.3 EDK40224.2 - 0.00097 19.3 0.0 5.8 7.2 0.0 3.8 3 0 0 3 3 3 1 Cobalamin biosynthesis central region Nup35_RRM_2 PF14605.1 EDK40224.2 - 0.0075 16.0 0.1 6.9 6.5 0.0 3.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.1 EDK40224.2 - 0.11 11.9 0.0 21 4.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) OB_RNB PF08206.6 EDK40224.2 - 0.12 11.9 1.3 20 4.7 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain DUF4078 PF13300.1 EDK40224.2 - 0.18 11.9 5.8 0.47 10.6 0.5 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4078) YflT PF11181.3 EDK40224.2 - 0.4 10.8 4.4 10 6.3 0.3 3.4 4 0 0 4 4 4 0 Heat induced stress protein YflT SNF2_N PF00176.18 EDK40225.2 - 2.3e-71 240.0 0.7 3.5e-71 239.4 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF4208 PF13907.1 EDK40225.2 - 3e-27 94.7 1.6 3e-27 94.7 1.1 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Chromo PF00385.19 EDK40225.2 - 4.6e-21 74.2 7.0 8.3e-13 47.8 1.2 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 EDK40225.2 - 1.6e-15 56.6 0.0 6.2e-15 54.8 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ABC_tran PF00005.22 EDK40226.2 - 9e-34 116.7 0.0 1e-15 58.2 0.0 2.5 2 1 0 2 2 2 2 ABC transporter RLI PF04068.10 EDK40226.2 - 1.6e-13 49.9 5.2 3.8e-13 48.7 3.6 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.1 EDK40226.2 - 1.9e-13 51.0 6.4 0.0058 16.6 0.0 4.3 2 2 2 4 4 4 4 AAA domain SMC_N PF02463.14 EDK40226.2 - 9.3e-10 38.0 0.9 0.016 14.4 0.0 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.22 EDK40226.2 - 5.1e-08 32.1 3.3 5.1e-08 32.1 2.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA PF00004.24 EDK40226.2 - 8.3e-06 26.0 0.0 0.029 14.5 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK40226.2 - 1.2e-05 25.4 0.1 0.054 13.6 0.0 3.1 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EDK40226.2 - 1.5e-05 25.7 0.1 0.17 12.6 0.0 3.0 2 2 0 2 2 2 2 AAA domain Fer4_6 PF12837.2 EDK40226.2 - 3.8e-05 23.3 2.8 3.8e-05 23.3 2.0 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.1 EDK40226.2 - 4.8e-05 22.7 0.2 0.047 13.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_15 PF13175.1 EDK40226.2 - 7.5e-05 21.9 0.3 2 7.3 0.0 4.4 5 0 0 5 5 5 1 AAA ATPase domain DUF258 PF03193.11 EDK40226.2 - 0.00019 20.6 2.1 0.34 10.1 0.0 3.0 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_18 PF13238.1 EDK40226.2 - 0.00019 21.7 0.1 0.85 9.9 0.0 2.9 2 1 0 2 2 2 2 AAA domain Fer4_21 PF14697.1 EDK40226.2 - 0.0004 20.1 11.8 0.00087 19.0 8.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 EDK40226.2 - 0.0007 19.3 2.4 0.0007 19.3 1.6 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_25 PF13481.1 EDK40226.2 - 0.0007 19.0 0.1 0.13 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EDK40226.2 - 0.00089 19.7 0.0 1.9 8.9 0.0 2.9 3 0 0 3 3 2 1 Miro-like protein VirE PF05272.6 EDK40226.2 - 0.0012 18.3 0.0 0.74 9.2 0.0 2.5 2 0 0 2 2 2 1 Virulence-associated protein E Fer4_7 PF12838.2 EDK40226.2 - 0.0016 18.7 2.0 0.0016 18.7 1.4 2.4 1 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EDK40226.2 - 0.0018 18.0 1.3 0.0018 18.0 0.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 EDK40226.2 - 0.0024 18.0 2.1 0.0024 18.0 1.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_33 PF13671.1 EDK40226.2 - 0.0031 17.3 0.0 0.72 9.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain NACHT PF05729.7 EDK40226.2 - 0.0034 17.0 0.9 1 9.0 0.0 2.7 3 0 0 3 3 2 1 NACHT domain Fer4_16 PF13484.1 EDK40226.2 - 0.0042 17.8 0.1 0.0042 17.8 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain RNA_helicase PF00910.17 EDK40226.2 - 0.0042 17.2 0.1 1.1 9.5 0.0 2.7 2 0 0 2 2 2 1 RNA helicase MobB PF03205.9 EDK40226.2 - 0.0044 16.7 0.4 1.2 8.8 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 EDK40226.2 - 0.0048 16.9 0.0 0.89 9.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Fer4_3 PF12798.2 EDK40226.2 - 0.0058 17.1 4.2 0.0058 17.1 2.9 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_13 PF13166.1 EDK40226.2 - 0.0071 14.8 0.3 0.022 13.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 EDK40226.2 - 0.01 15.2 2.3 0.57 9.5 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain UPF0079 PF02367.12 EDK40226.2 - 0.012 15.2 0.3 0.11 12.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 EDK40226.2 - 0.012 15.9 0.1 0.66 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 EDK40226.2 - 0.019 14.8 0.1 5.5 6.9 0.0 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_8 PF13183.1 EDK40226.2 - 0.025 14.6 7.9 0.056 13.4 5.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain NB-ARC PF00931.17 EDK40226.2 - 0.029 13.2 0.0 0.69 8.7 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.9 EDK40226.2 - 0.051 13.3 1.0 0.49 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EDK40226.2 - 0.057 13.3 1.0 13 5.6 0.0 3.1 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.1 EDK40226.2 - 0.063 13.2 0.5 16 5.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 EDK40226.2 - 0.11 11.9 0.7 0.56 9.6 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.10 EDK40226.2 - 0.13 10.9 0.0 1.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_30 PF13604.1 EDK40226.2 - 0.14 11.7 0.4 3 7.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.12 EDK40226.2 - 0.15 11.3 0.4 22 4.3 0.0 2.9 3 0 0 3 3 3 0 Thymidylate kinase AAA_24 PF13479.1 EDK40226.2 - 0.18 11.3 0.6 3 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Fer4_4 PF12800.2 EDK40226.2 - 0.26 11.7 13.6 0.05 13.9 1.7 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Peptidase_M24 PF00557.19 EDK40227.1 - 3e-07 30.2 0.0 4.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 14-3-3 PF00244.15 EDK40228.1 - 2.8e-114 380.0 4.6 3.2e-114 379.8 3.2 1.0 1 0 0 1 1 1 1 14-3-3 protein SpoIIIAH PF12685.2 EDK40228.1 - 0.11 11.9 2.0 0.15 11.5 0.8 1.6 2 0 0 2 2 2 0 SpoIIIAH-like protein Septin PF00735.13 EDK40229.2 - 1.9e-113 378.1 0.0 3.3e-113 377.3 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EDK40229.2 - 3.3e-07 30.2 0.0 6.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 EDK40229.2 - 5.3e-05 22.4 1.6 0.00015 20.9 0.2 2.3 2 1 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 EDK40229.2 - 6.2e-05 22.5 0.0 0.00087 18.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 EDK40229.2 - 0.0035 17.3 0.2 0.01 15.8 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain Miro PF08477.8 EDK40229.2 - 0.0037 17.7 0.0 0.012 16.1 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 EDK40229.2 - 0.0076 16.3 0.0 0.021 14.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain AIG1 PF04548.11 EDK40229.2 - 0.0094 15.0 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 AIG1 family FtsK_SpoIIIE PF01580.13 EDK40229.2 - 0.017 14.6 0.0 0.052 13.0 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ras PF00071.17 EDK40229.2 - 0.02 14.2 0.1 0.11 11.8 0.1 2.1 1 1 0 1 1 1 0 Ras family Dynamin_N PF00350.18 EDK40229.2 - 0.021 14.6 5.6 2.1 8.1 0.0 3.2 2 1 1 3 3 3 0 Dynamin family NACHT PF05729.7 EDK40229.2 - 0.027 14.1 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 EDK40229.2 - 0.029 14.6 0.1 0.094 13.0 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.1 EDK40229.2 - 0.033 13.7 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 EDK40229.2 - 0.037 13.0 0.7 0.061 12.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RRF_GI PF12614.3 EDK40229.2 - 0.05 13.4 1.7 0.11 12.3 1.2 1.5 1 0 0 1 1 1 0 Ribosome recycling factor T2SE PF00437.15 EDK40229.2 - 0.082 11.7 0.2 0.17 10.7 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF641 PF04859.7 EDK40229.2 - 0.091 12.5 3.5 0.091 12.5 0.9 2.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) PduV-EutP PF10662.4 EDK40229.2 - 0.094 12.2 0.0 0.69 9.4 0.0 2.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 EDK40229.2 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF29 PF01724.11 EDK40229.2 - 0.18 11.6 3.7 0.15 11.8 1.2 1.9 2 1 0 2 2 1 0 Domain of unknown function DUF29 KAP_NTPase PF07693.9 EDK40229.2 - 0.35 9.8 3.9 0.45 9.4 1.9 1.9 1 1 1 2 2 2 0 KAP family P-loop domain Zn_clus PF00172.13 EDK40230.2 - 8.6e-08 31.9 8.3 1.4e-07 31.2 5.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK40230.2 - 8.4e-06 24.8 8.5 2.4e-05 23.3 2.6 3.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain Fungal_trans PF04082.13 EDK40231.2 - 7.7e-16 57.7 0.3 1.3e-15 56.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40231.2 - 2e-09 37.2 10.6 3.2e-09 36.5 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tropomyosin PF00261.15 EDK40231.2 - 0.013 14.6 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Tropomyosin SUN PF03856.8 EDK40232.2 - 5.9e-84 281.2 18.2 6.8e-84 281.0 12.6 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF333 PF03891.10 EDK40232.2 - 0.15 11.9 3.8 0.38 10.6 0.1 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF333) SieB PF14163.1 EDK40233.2 - 0.31 10.5 4.3 0.55 9.7 3.0 1.4 1 0 0 1 1 1 0 Superinfection exclusion protein B DUF4231 PF14015.1 EDK40233.2 - 0.52 10.3 2.2 0.95 9.4 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Tetraspannin PF00335.15 EDK40233.2 - 0.69 9.1 6.5 6.4 5.9 1.1 2.5 2 1 0 2 2 2 0 Tetraspanin family HSA PF07529.8 EDK40234.2 - 1.3e-13 50.4 0.0 1.3e-13 50.4 0.0 3.0 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.1 EDK40234.2 - 4.4e-09 36.2 0.6 1.8e-08 34.3 0.4 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 EDK40234.2 - 0.078 13.0 0.1 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain PH_4 PF15404.1 EDK40235.2 - 1.5e-58 197.4 0.3 4.9e-58 195.7 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.1 EDK40235.2 - 4.2e-24 83.7 1.1 1.3e-23 82.2 0.1 2.5 2 0 0 2 2 2 1 Sporulation protein family 7 PH PF00169.24 EDK40235.2 - 6.3e-08 32.7 0.2 0.038 14.1 0.0 4.0 3 1 0 3 3 3 2 PH domain PH_6 PF15406.1 EDK40235.2 - 0.0022 18.0 0.0 1.2 9.2 0.0 3.4 4 0 0 4 4 4 1 Pleckstrin homology domain UPF0546 PF10639.4 EDK40235.2 - 0.19 11.5 0.0 0.85 9.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 PH_10 PF15411.1 EDK40236.2 - 0.079 13.1 0.2 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain C1_1 PF00130.17 EDK40236.2 - 0.44 10.3 3.6 0.98 9.2 2.5 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.1 EDK40236.2 - 0.67 9.8 7.3 1.6 8.6 5.1 1.7 1 0 0 1 1 1 0 Ring finger domain E1_dh PF00676.15 EDK40237.2 - 4.9e-120 399.7 0.1 5.9e-120 399.5 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 EDK40237.2 - 0.0023 16.9 0.0 0.004 16.1 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.1 EDK40237.2 - 1 10.0 5.6 1.2 9.7 0.2 3.1 2 2 1 3 3 3 0 KRTAP type 7 family Sec63 PF02889.11 EDK40238.2 - 1.5e-92 310.1 0.2 3e-92 309.1 0.1 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 EDK40238.2 - 1.6e-38 131.8 0.0 9.2e-29 100.0 0.0 2.9 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 EDK40238.2 - 1.7e-10 41.0 0.0 6.2e-10 39.2 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EDK40238.2 - 3.1e-09 36.5 0.0 9.5e-09 35.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 EDK40238.2 - 0.00066 19.8 0.2 0.0067 16.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 EDK40238.2 - 0.0016 18.1 0.0 1.2 8.9 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain Glycos_transf_3 PF00591.16 EDK40240.1 - 5.9e-64 215.9 0.0 6.7e-64 215.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain WEMBL PF05701.6 EDK40241.2 - 7.9e-05 21.3 30.3 7.9e-05 21.3 21.0 6.1 1 1 2 3 3 3 2 Weak chloroplast movement under blue light DUF869 PF05911.6 EDK40241.2 - 0.00096 17.5 125.8 0.0061 14.8 16.7 6.0 1 1 2 4 4 4 4 Plant protein of unknown function (DUF869) GAS PF13851.1 EDK40241.2 - 0.0016 17.6 18.0 0.0016 17.6 12.5 9.0 3 1 7 10 10 10 2 Growth-arrest specific micro-tubule binding IncA PF04156.9 EDK40241.2 - 0.0017 17.9 35.6 0.0045 16.5 12.9 10.0 1 1 8 9 9 9 4 IncA protein CENP-F_leu_zip PF10473.4 EDK40241.2 - 0.0047 16.7 16.6 0.0047 16.7 11.5 10.2 3 2 7 10 10 10 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.7 EDK40241.2 - 0.0071 16.1 9.0 0.0071 16.1 6.2 9.2 4 2 6 10 10 10 2 Laminin Domain II Tropomyosin_1 PF12718.2 EDK40241.2 - 0.0077 16.0 19.1 0.0077 16.0 13.3 9.2 2 2 5 8 8 8 5 Tropomyosin like Prefoldin PF02996.12 EDK40241.2 - 0.01 15.4 1.6 0.01 15.4 1.1 14.5 11 5 2 16 16 16 0 Prefoldin subunit FliJ PF02050.11 EDK40241.2 - 0.028 14.4 0.6 0.028 14.4 0.4 11.1 4 2 9 13 13 13 0 Flagellar FliJ protein MtrB PF05440.7 EDK40241.2 - 0.66 10.0 3.4 4.7 7.3 0.0 4.0 4 1 1 5 5 5 0 Tetrahydromethanopterin S-methyltransferase subunit B Apc13p PF05839.6 EDK40242.2 - 4.9e-06 26.4 0.8 1.3e-05 25.0 0.6 1.7 1 1 0 1 1 1 1 Apc13p protein SEEEED PF14797.1 EDK40243.2 - 0.001 19.1 13.0 0.001 19.1 9.0 2.2 2 0 0 2 2 2 1 Serine-rich region of AP3B1, clathrin-adaptor complex CDK2AP PF09806.4 EDK40243.2 - 4 7.6 13.3 3.4 7.8 3.3 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Secretin_N_2 PF07655.8 EDK40243.2 - 7.3 7.0 18.2 4 7.9 1.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Zip PF02535.17 EDK40244.2 - 7.8e-11 41.5 4.6 1.7e-10 40.4 3.2 1.5 1 0 0 1 1 1 1 ZIP Zinc transporter Thyroglobulin_1 PF00086.13 EDK40244.2 - 0.019 14.3 1.4 6.8 6.1 0.0 3.3 3 1 0 3 3 3 0 Thyroglobulin type-1 repeat NARG2_C PF10505.4 EDK40244.2 - 0.15 11.1 0.0 0.85 8.7 0.0 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus RNA_pol_Rpb1_5 PF04998.12 EDK40245.2 - 1.8e-97 325.9 0.0 3e-97 325.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 EDK40245.2 - 9.9e-70 233.7 0.1 3.7e-69 231.9 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.7 EDK40245.2 - 4e-66 223.5 0.0 6.5e-66 222.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.13 EDK40245.2 - 1.7e-38 131.8 0.0 6.8e-38 129.8 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 EDK40245.2 - 3.2e-31 107.2 0.1 1.2e-30 105.3 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 DSS1_SEM1 PF05160.8 EDK40246.1 - 8.9e-24 83.0 18.6 9.8e-24 82.9 12.9 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family RNase_H2_suC PF08615.6 EDK40246.1 - 0.93 9.3 3.6 1 9.2 2.5 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) AAA PF00004.24 EDK40247.2 - 6.8e-41 139.5 0.0 1.2e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK40247.2 - 4.6e-05 23.4 2.0 0.008 16.1 0.0 3.2 3 1 1 4 4 4 1 AAA ATPase domain AAA_2 PF07724.9 EDK40247.2 - 6.4e-05 22.9 0.0 0.00022 21.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EDK40247.2 - 0.00038 19.5 0.0 0.0014 17.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EDK40247.2 - 0.00067 19.8 0.3 0.024 14.7 0.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EDK40247.2 - 0.00086 19.0 0.1 0.0065 16.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 EDK40247.2 - 0.0017 18.2 0.0 0.0055 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 EDK40247.2 - 0.011 14.9 0.1 0.038 13.2 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.8 EDK40247.2 - 0.012 14.4 0.0 0.032 13.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_19 PF13245.1 EDK40247.2 - 0.016 14.9 0.2 0.043 13.5 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain Mg_chelatase PF01078.16 EDK40247.2 - 0.019 14.1 0.2 0.05 12.7 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 EDK40247.2 - 0.02 14.3 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 EDK40247.2 - 0.036 13.4 1.3 0.29 10.5 0.2 2.3 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.1 EDK40247.2 - 0.036 14.8 0.1 0.14 13.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.6 EDK40247.2 - 0.044 13.6 1.6 0.13 12.1 1.1 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) AAA_14 PF13173.1 EDK40247.2 - 0.056 13.3 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 EDK40247.2 - 0.093 12.2 1.6 0.19 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain Glyco_hydro_1 PF00232.13 EDK40248.2 - 7.8e-77 258.3 1.3 2.3e-75 253.5 0.9 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_cc PF11790.3 EDK40248.2 - 0.0019 17.6 0.2 0.0059 16.0 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase catalytic core Peptidase_M24 PF00557.19 EDK40249.1 - 1.7e-44 151.9 0.0 2e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-MYND PF01753.13 EDK40249.1 - 0.0052 16.6 3.8 0.0052 16.6 2.7 2.0 2 0 0 2 2 2 1 MYND finger Translin PF01997.11 EDK40250.2 - 3e-57 193.4 0.2 3.4e-57 193.2 0.1 1.0 1 0 0 1 1 1 1 Translin family Occludin_ELL PF07303.8 EDK40250.2 - 0.044 14.5 0.0 0.13 13.0 0.0 1.8 2 0 0 2 2 2 0 Occludin homology domain Cpn60_TCP1 PF00118.19 EDK40251.2 - 8.4e-148 492.9 0.4 9.6e-148 492.7 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Zn_clus PF00172.13 EDK40252.2 - 8.2e-06 25.6 11.9 1.5e-05 24.7 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec1 PF00995.18 EDK40254.2 - 3.3e-140 468.4 3.3 3.8e-140 468.2 2.3 1.0 1 0 0 1 1 1 1 Sec1 family TIP49 PF06068.8 EDK40255.2 - 4.3e-186 618.4 0.3 5.2e-186 618.1 0.2 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 EDK40255.2 - 2e-14 53.2 0.6 3.7e-07 29.4 0.0 3.1 3 0 0 3 3 3 3 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 EDK40255.2 - 2.6e-10 40.5 0.3 1.7e-06 28.3 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK40255.2 - 5.4e-07 29.7 0.2 0.0069 16.3 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 EDK40255.2 - 5e-06 26.6 0.2 0.16 12.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.9 EDK40255.2 - 0.00026 20.7 0.1 0.072 12.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 EDK40255.2 - 0.00044 19.4 0.2 0.0017 17.4 0.1 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 EDK40255.2 - 0.00077 19.1 0.2 0.0035 17.0 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain Sigma54_activat PF00158.21 EDK40255.2 - 0.0011 18.4 0.0 0.79 9.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.1 EDK40255.2 - 0.0016 17.8 0.0 0.0035 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 EDK40255.2 - 0.0017 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 EDK40255.2 - 0.0019 17.3 0.1 0.08 12.0 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 EDK40255.2 - 0.0023 17.8 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EDK40255.2 - 0.0063 16.8 0.1 0.021 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 EDK40255.2 - 0.0092 16.7 0.0 0.027 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EDK40255.2 - 0.011 15.1 0.1 0.027 13.8 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2075 PF09848.4 EDK40255.2 - 0.028 13.3 0.0 0.047 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) GvpD PF07088.6 EDK40255.2 - 0.044 12.1 0.1 0.39 8.9 0.0 2.0 2 0 0 2 2 2 0 GvpD gas vesicle protein PIF1 PF05970.9 EDK40255.2 - 0.045 12.7 0.0 2.3 7.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_33 PF13671.1 EDK40255.2 - 0.061 13.1 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 EDK40255.2 - 0.077 12.8 0.1 0.81 9.4 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DnaB_C PF03796.10 EDK40255.2 - 0.093 11.6 0.0 0.19 10.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ATP-synt_ab PF00006.20 EDK40255.2 - 0.11 11.9 0.2 0.92 8.9 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.12 EDK40256.2 - 5e-84 281.5 0.0 5.8e-84 281.3 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 EDK40256.2 - 0.00044 19.1 0.0 0.0014 17.5 0.0 1.7 2 0 0 2 2 2 1 ArgK protein AAA_10 PF12846.2 EDK40256.2 - 0.0013 18.2 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_17 PF13207.1 EDK40256.2 - 0.0017 19.1 0.0 0.003 18.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 EDK40256.2 - 0.0066 16.3 0.0 0.013 15.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase KAP_NTPase PF07693.9 EDK40256.2 - 0.026 13.5 0.0 0.074 12.0 0.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain RNA_helicase PF00910.17 EDK40256.2 - 0.027 14.6 0.0 0.088 12.9 0.0 1.9 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.22 EDK40256.2 - 0.03 14.6 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.1 EDK40256.2 - 0.057 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.13 EDK40256.2 - 0.069 12.3 0.0 0.31 10.1 0.0 2.0 2 1 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_29 PF13555.1 EDK40256.2 - 0.096 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.1 EDK40256.2 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 EDK40256.2 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 EDK40256.2 - 0.14 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 T2SE PF00437.15 EDK40256.2 - 0.15 10.9 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 EDK40256.2 - 0.19 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cation_efflux PF01545.16 EDK40257.2 - 4.2e-53 180.2 2.3 4.2e-53 180.2 1.6 2.2 2 1 0 2 2 2 1 Cation efflux family His_Phos_1 PF00300.17 EDK40258.2 - 1.3e-14 54.5 0.0 2.8e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PI3_PI4_kinase PF00454.22 EDK40259.2 - 8.5e-41 139.9 0.0 5.4e-40 137.3 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 EDK40259.2 - 2.6e-36 124.5 4.3 2.1e-22 79.2 0.2 2.6 2 0 0 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.19 EDK40259.2 - 4.2e-26 91.4 0.1 9.2e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 CoaE PF01121.15 EDK40260.2 - 9.7e-61 204.3 0.0 1.2e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 EDK40260.2 - 1.3e-05 25.9 0.1 3.3e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK40260.2 - 0.00084 19.6 0.1 0.0034 17.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EDK40260.2 - 0.036 13.9 0.2 0.67 9.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EDK40260.2 - 0.046 13.6 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain ApbA_C PF08546.6 EDK40261.2 - 8.3e-35 119.5 0.2 1.4e-34 118.7 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EDK40261.2 - 1.2e-28 99.5 0.0 1.7e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 EDK40261.2 - 0.033 13.9 0.0 0.2 11.3 0.0 2.3 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Saccharop_dh PF03435.13 EDK40261.2 - 0.047 12.6 0.0 0.077 11.9 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase SET PF00856.23 EDK40262.2 - 4.8e-22 78.9 0.0 3.6e-21 76.1 0.0 2.0 2 0 0 2 2 2 1 SET domain Topoisom_bac PF01131.15 EDK40263.2 - 7.2e-97 324.7 0.0 8.7e-97 324.4 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 EDK40263.2 - 1.3e-18 66.8 0.0 3.4e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Toprim_4 PF13662.1 EDK40263.2 - 0.09 12.7 0.0 7.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Toprim domain zf-CCCH PF00642.19 EDK40264.2 - 1.3e-07 31.0 1.4 2.6e-07 30.1 1.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 EDK40264.2 - 0.59 10.2 2.5 1.4 9.0 1.8 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type DUF221 PF02714.10 EDK40265.2 - 1.6e-99 332.8 22.3 1.6e-99 332.8 15.5 1.9 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EDK40265.2 - 8.4e-37 126.1 5.4 3.2e-36 124.2 3.8 2.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EDK40265.2 - 7e-14 52.1 0.0 3.5e-13 49.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4463) RRM_6 PF14259.1 EDK40265.2 - 0.067 13.1 0.0 0.75 9.8 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FTA4 PF13093.1 EDK40266.2 - 3.5e-41 140.9 15.0 4.2e-41 140.7 10.4 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 GSH_synth_ATP PF03917.12 EDK40266.2 - 0.02 13.4 0.5 0.024 13.2 0.3 1.1 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain Mac PF12464.3 EDK40266.2 - 0.06 13.3 0.3 0.26 11.3 0.2 2.2 1 0 0 1 1 1 0 Maltose acetyltransferase Terminase_4 PF05119.7 EDK40266.2 - 0.11 12.6 1.0 0.28 11.3 0.0 2.2 2 1 0 2 2 2 0 Phage terminase, small subunit PBP_dimer PF03717.10 EDK40266.2 - 0.18 11.8 6.9 1.4 8.9 4.8 2.0 1 1 0 1 1 1 0 Penicillin-binding Protein dimerisation domain FERM_M PF00373.13 EDK40266.2 - 5.8 7.1 7.7 4.4 7.4 2.7 2.2 1 1 1 2 2 2 0 FERM central domain Glyco_hydro_18 PF00704.23 EDK40267.1 - 1.8e-36 126.2 7.5 1.8e-36 126.2 5.2 1.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.14 EDK40267.1 - 5e-08 32.8 16.2 2e-07 30.8 10.9 2.3 1 1 0 1 1 1 1 Chitin recognition protein Ribosomal_60s PF00428.14 EDK40268.1 - 1.4e-26 92.6 11.7 1.7e-26 92.4 8.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_S19 PF00203.16 EDK40269.1 - 6.5e-32 108.9 0.1 7.8e-32 108.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Mito_carr PF00153.22 EDK40270.2 - 2.4e-57 190.6 6.0 2.1e-20 72.1 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein HTH_34 PF13601.1 EDK40271.2 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Mito_carr PF00153.22 EDK40272.2 - 1.5e-45 152.8 1.2 1.8e-14 53.1 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF456 PF04306.8 EDK40272.2 - 0.39 10.7 6.2 0.23 11.4 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF456) TetR_C PF02909.12 EDK40273.2 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 1 0 1 1 1 0 Tetracyclin repressor, C-terminal all-alpha domain SPA PF08616.5 EDK40274.2 - 6.6e-35 119.2 0.1 2e-34 117.6 0.1 1.9 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.7 EDK40274.2 - 9.6e-32 109.9 0.0 2.2e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.4 EDK40274.2 - 2.1e-12 46.2 1.1 4.1e-07 28.8 0.0 2.6 2 1 0 2 2 2 2 Transport protein Avl9 DUF2347 PF09804.4 EDK40274.2 - 2.9e-05 23.5 0.1 0.026 13.7 0.1 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) DENN PF02141.16 EDK40274.2 - 0.064 12.9 1.9 3.4 7.3 0.1 2.9 2 1 0 2 2 2 0 DENN (AEX-3) domain zf-H2C2_2 PF13465.1 EDK40275.2 - 5.7e-05 23.2 4.8 0.057 13.7 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 EDK40275.2 - 0.00017 21.7 13.8 0.0007 19.7 2.1 3.7 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK40275.2 - 0.018 15.3 10.3 0.22 11.9 1.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger C1_4 PF07975.7 EDK40275.2 - 0.65 10.0 7.3 3.4 7.7 0.9 2.6 2 1 0 2 2 2 0 TFIIH C1-like domain zf-H2C2_5 PF13909.1 EDK40275.2 - 5.9 7.3 9.2 7.2 7.0 1.7 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain SprT-like PF10263.4 EDK40275.2 - 8.9 5.9 9.8 76 2.9 6.8 2.2 1 1 0 1 1 1 0 SprT-like family RGS PF00615.14 EDK40276.2 - 1e-06 28.8 0.2 6.5e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain Claudin_2 PF13903.1 EDK40276.2 - 0.15 11.6 3.1 0.11 12.2 0.3 1.8 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4234 PF14018.1 EDK40276.2 - 7.9 6.3 8.4 11 5.8 1.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) Ribosomal_L19e PF01280.15 EDK40277.1 - 2.5e-47 160.3 9.0 2.5e-47 160.3 6.3 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e DUF2423 PF10338.4 EDK40278.2 - 3e-20 71.9 9.0 3e-20 71.9 6.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) L27_2 PF09045.5 EDK40278.2 - 0.36 10.4 2.7 0.38 10.3 0.4 2.1 1 1 1 2 2 2 0 L27_2 AIRC PF00731.15 EDK40279.2 - 4.7e-65 217.4 1.9 9.1e-65 216.5 1.3 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.17 EDK40279.2 - 2.6e-61 205.9 0.0 4.1e-61 205.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 EDK40279.2 - 2.4e-10 40.4 0.1 4.3e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain 2-Hacid_dh_C PF02826.14 EDK40279.2 - 4.5e-05 22.6 0.0 0.0001 21.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CPSase_L_D2 PF02786.12 EDK40279.2 - 4.8e-05 22.7 0.0 0.00011 21.6 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain NAD_binding_2 PF03446.10 EDK40279.2 - 0.0018 18.1 1.9 0.29 10.9 0.0 2.8 3 0 0 3 3 3 2 NAD binding domain of 6-phosphogluconate dehydrogenase Dala_Dala_lig_C PF07478.8 EDK40279.2 - 0.003 16.9 0.0 0.061 12.7 0.0 2.4 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CoA_binding_2 PF13380.1 EDK40279.2 - 0.0034 17.5 0.8 15 5.7 0.0 3.7 2 1 1 3 3 3 0 CoA binding domain NAD_binding_10 PF13460.1 EDK40279.2 - 0.022 14.7 0.2 0.054 13.4 0.1 1.7 1 0 0 1 1 1 0 NADH(P)-binding ATPgrasp_Ter PF15632.1 EDK40279.2 - 0.047 12.4 0.0 0.15 10.7 0.0 1.8 3 0 0 3 3 3 0 ATP-grasp in the biosynthetic pathway with Ter operon XdhC_C PF13478.1 EDK40279.2 - 0.048 13.9 0.1 0.77 10.0 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain ATP-grasp_3 PF02655.9 EDK40279.2 - 0.099 12.4 0.0 0.35 10.7 0.0 2.1 1 1 0 1 1 1 0 ATP-grasp domain Thioredoxin PF00085.15 EDK40279.2 - 0.1 12.2 0.1 0.62 9.7 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin TEA PF01285.13 EDK40281.2 - 2.1e-28 99.6 0.0 3e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 TEA/ATTS domain family DUF2370 PF10176.4 EDK40281.2 - 0.017 14.4 0.8 0.031 13.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) zf-HC5HC2H_2 PF13832.1 EDK40282.2 - 7.3e-34 116.0 4.7 7.3e-34 116.0 3.3 2.8 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 EDK40282.2 - 8.8e-29 99.5 2.5 8.8e-29 99.5 1.7 3.6 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.1 EDK40282.2 - 1.5e-12 46.6 1.7 1.5e-12 46.6 1.2 2.9 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 EDK40282.2 - 4e-09 36.0 24.3 3.6e-08 32.9 6.3 2.8 2 0 0 2 2 2 2 PHD-finger EPL1 PF10513.4 EDK40282.2 - 5.1e-09 36.5 0.0 1.3e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-RING-like PF08746.6 EDK40282.2 - 0.16 11.9 26.1 0.04 13.9 6.0 3.6 3 1 0 3 3 3 0 RING-like domain Prok-RING_1 PF14446.1 EDK40282.2 - 2.5 7.9 28.4 0.35 10.6 4.9 3.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 CBF PF03914.12 EDK40283.2 - 4.3e-44 149.8 0.1 4.3e-44 149.8 0.1 3.1 3 0 0 3 3 3 1 CBF/Mak21 family HEAT PF02985.17 EDK40283.2 - 0.19 11.8 1.0 24 5.3 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat Mem_trans PF03547.13 EDK40283.2 - 0.43 8.8 1.3 0.73 8.0 0.9 1.5 1 0 0 1 1 1 0 Membrane transport protein Parvo_coat PF00740.13 EDK40283.2 - 1 8.2 6.6 2.1 7.2 4.6 1.4 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Ras PF00071.17 EDK40284.2 - 1.8e-28 98.9 0.0 2.4e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40284.2 - 5.4e-09 36.5 0.0 1.2e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein AAA_24 PF13479.1 EDK40284.2 - 0.0026 17.3 0.2 0.0059 16.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 EDK40284.2 - 0.043 13.7 0.0 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 EDK40284.2 - 0.19 11.7 0.6 0.4 10.6 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.20 EDK40285.2 - 2.2e-64 217.1 0.0 3.6e-64 216.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40285.2 - 1.7e-35 122.3 0.0 2.9e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 EDK40285.2 - 2.1e-32 110.6 7.4 2.9e-16 58.9 1.5 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 EDK40285.2 - 8e-19 67.1 33.3 4e-10 39.2 9.3 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 EDK40285.2 - 2.4e-12 47.1 1.7 2.4e-12 47.1 1.2 2.9 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EDK40285.2 - 2.5e-06 26.6 0.1 1.2e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like C2 PF00168.25 EDK40285.2 - 0.0003 20.5 0.1 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain Uds1 PF15456.1 EDK40285.2 - 0.018 15.0 2.0 0.023 14.6 0.1 2.1 2 0 0 2 2 2 0 Up-regulated During Septation DUF4206 PF13901.1 EDK40285.2 - 4 6.9 23.7 0.36 10.3 4.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4206) zf-RING_3 PF14369.1 EDK40286.2 - 0.026 14.5 3.7 0.25 11.3 0.4 3.3 3 0 0 3 3 3 0 zinc-finger Zn_Tnp_IS1595 PF12760.2 EDK40286.2 - 0.068 12.9 1.0 0.068 12.9 0.7 3.5 3 1 0 3 3 3 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.1 EDK40286.2 - 1.7 7.9 7.9 34 3.8 3.6 3.2 2 1 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 EDK40286.2 - 5.5 6.8 12.0 16 5.3 5.4 3.0 2 1 0 2 2 2 0 Double zinc ribbon WD40 PF00400.27 EDK40287.2 - 0.049 13.5 4.3 12 5.9 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Pkinase PF00069.20 EDK40288.2 - 1.2e-73 247.4 0.0 2.5e-73 246.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40288.2 - 3.8e-36 124.4 0.0 1.1e-35 122.9 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40288.2 - 0.0047 15.9 0.3 0.021 13.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK40288.2 - 0.045 13.4 0.0 0.045 13.4 0.0 1.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.20 EDK40289.2 - 9.8e-71 237.9 0.0 1.4e-70 237.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40289.2 - 5.6e-31 107.5 0.0 8e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 EDK40289.2 - 7.1e-10 39.2 4.1 7.1e-10 39.2 2.8 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 EDK40289.2 - 0.0018 17.3 0.0 0.0048 15.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 EDK40289.2 - 0.006 15.6 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK40289.2 - 0.027 14.2 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family MRP-L28 PF09812.4 EDK40291.1 - 1.5e-31 109.3 3.5 1.8e-31 109.1 2.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Orbi_VP5 PF00901.12 EDK40291.1 - 0.0015 16.8 0.4 0.0018 16.5 0.3 1.0 1 0 0 1 1 1 1 Orbivirus outer capsid protein VP5 Sema PF01403.14 EDK40291.1 - 0.014 13.9 0.1 0.017 13.7 0.0 1.1 1 0 0 1 1 1 0 Sema domain Imm-NTF2 PF15655.1 EDK40291.1 - 0.034 14.6 1.5 0.043 14.2 1.0 1.1 1 0 0 1 1 1 0 NTF2 fold immunity protein CDK5_activator PF03261.10 EDK40291.1 - 0.076 12.3 0.7 0.085 12.1 0.5 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DivIC PF04977.10 EDK40291.1 - 4.9 6.7 7.0 0.74 9.3 2.3 1.5 2 0 0 2 2 2 0 Septum formation initiator NuA4 PF09340.5 EDK40292.2 - 2.9e-26 90.9 4.8 4e-26 90.4 3.3 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 BBS2_C PF14782.1 EDK40292.2 - 0.046 12.2 0.1 0.046 12.2 0.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Enolase_C PF00113.17 EDK40293.1 - 1.5e-154 513.2 0.0 2e-154 512.8 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 EDK40293.1 - 2.1e-56 189.4 0.0 3.7e-56 188.6 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain Aminotran_5 PF00266.14 EDK40294.2 - 6e-12 44.9 0.0 1.3e-11 43.9 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 EDK40294.2 - 0.029 12.6 0.0 0.042 12.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 EDK40294.2 - 0.038 13.0 0.1 0.09 11.7 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Clat_adaptor_s PF01217.15 EDK40295.2 - 4.4e-44 149.6 2.8 5.3e-44 149.3 2.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CBP4 PF07960.6 EDK40296.2 - 2.9e-49 165.9 1.9 3.2e-49 165.7 1.3 1.0 1 0 0 1 1 1 1 CBP4 DUF2105 PF09878.4 EDK40296.2 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2105) SspO PF08175.7 EDK40296.2 - 0.2 11.9 0.9 0.43 10.9 0.7 1.5 1 0 0 1 1 1 0 Small acid-soluble spore protein O family LAMTOR PF15454.1 EDK40296.2 - 0.44 10.8 0.1 0.44 10.8 0.1 2.2 2 1 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Fungal_trans_2 PF11951.3 EDK40297.2 - 1.7e-11 43.3 0.6 2.3e-11 42.9 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40297.2 - 2.5e-06 27.2 8.8 2.5e-06 27.2 6.1 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ras PF00071.17 EDK40298.1 - 2.3e-49 166.8 0.0 2.7e-49 166.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40298.1 - 4.2e-13 49.8 0.0 6e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK40298.1 - 1.1e-06 28.0 0.0 1.4e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family HATPase_c PF02518.21 EDK40299.2 - 3.2e-27 94.4 0.3 6.1e-27 93.5 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 EDK40299.2 - 5.8e-18 64.9 0.1 1.6e-17 63.4 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain Pkinase PF00069.20 EDK40299.2 - 1.5e-17 63.5 0.0 3.3e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HisKA PF00512.20 EDK40299.2 - 1.3e-12 47.5 0.1 5.8e-12 45.4 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.1 EDK40299.2 - 1.5e-12 47.9 0.0 3.9e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Pkinase_Tyr PF07714.12 EDK40299.2 - 4.4e-12 45.6 0.0 9.8e-12 44.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase GAF_3 PF13492.1 EDK40299.2 - 1.2e-09 38.3 0.0 2.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.1 EDK40299.2 - 0.0016 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 EDK40299.2 - 0.027 14.5 0.0 0.16 12.0 0.0 2.4 3 0 0 3 3 3 0 GAF domain HMG_box_2 PF09011.5 EDK40300.2 - 8.9e-08 32.3 10.3 6e-07 29.7 2.8 4.3 3 3 0 3 3 3 2 HMG-box domain HMG_box PF00505.14 EDK40300.2 - 8.7e-05 22.7 1.4 8.7e-05 22.7 1.0 5.2 3 2 1 4 4 4 2 HMG (high mobility group) box DUF3470 PF11953.3 EDK40300.2 - 0.026 14.1 0.0 0.026 14.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3470) CI-B14_5a PF07347.7 EDK40300.2 - 0.033 13.9 0.2 0.033 13.9 0.2 2.7 2 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) CAF-1_p150 PF11600.3 EDK40300.2 - 1.3 8.3 35.4 0.015 14.6 19.2 1.6 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3106 PF11304.3 EDK40300.2 - 1.6 9.2 23.4 8.3 6.8 0.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) YABBY PF04690.8 EDK40300.2 - 2.2 8.4 10.8 0.78 9.9 2.8 2.6 3 0 0 3 3 3 0 YABBY protein DUF853 PF05872.7 EDK40300.2 - 2.4 6.3 7.4 3.5 5.8 5.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Mnd1 PF03962.10 EDK40300.2 - 3.1 7.4 25.5 0.89 9.1 0.7 2.2 2 0 0 2 2 2 0 Mnd1 family MRP-L46 PF11788.3 EDK40300.2 - 8.1 7.1 22.8 0.13 12.9 9.1 2.5 2 1 1 3 3 3 0 39S mitochondrial ribosomal protein L46 Cpn60_TCP1 PF00118.19 EDK40301.2 - 5.9e-143 477.0 14.7 6.7e-143 476.8 10.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cyclin_N PF00134.18 EDK40302.2 - 3.1e-13 49.4 0.0 4.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 EDK40302.2 - 8.5e-13 48.9 0.8 1.7e-12 48.0 0.0 1.9 2 1 1 3 3 3 1 Cyclin Na_Ca_ex PF01699.19 EDK40303.2 - 2.2e-50 169.8 31.2 2.5e-25 88.7 5.1 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SE PF08491.5 EDK40304.2 - 2.7e-119 397.0 0.0 3.4e-119 396.7 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 EDK40304.2 - 1.9e-15 56.7 0.0 2.2e-14 53.3 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 EDK40304.2 - 7e-13 48.2 2.6 1.2e-05 24.3 0.5 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK40304.2 - 2.3e-08 33.3 2.0 0.0012 17.8 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.17 EDK40304.2 - 1.2e-06 27.6 0.2 0.017 14.0 0.1 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.2 EDK40304.2 - 4.1e-06 26.1 2.6 0.0021 17.2 0.7 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase 3HCDH_N PF02737.13 EDK40304.2 - 9.4e-05 22.1 0.4 0.00018 21.2 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 EDK40304.2 - 0.00019 21.3 0.4 0.00041 20.2 0.3 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EDK40304.2 - 0.00021 20.0 2.9 0.017 13.7 0.0 2.4 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.7 EDK40304.2 - 0.00064 18.7 0.9 0.072 12.0 0.1 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein Shikimate_DH PF01488.15 EDK40304.2 - 0.0012 18.9 0.1 0.0024 17.9 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 EDK40304.2 - 0.0015 18.9 1.1 0.011 16.1 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EDK40304.2 - 0.002 17.2 0.6 0.007 15.4 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.1 EDK40304.2 - 0.0021 18.0 0.1 0.0057 16.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain adh_short PF00106.20 EDK40304.2 - 0.0089 15.9 2.0 1.6 8.6 0.1 2.5 2 0 0 2 2 2 1 short chain dehydrogenase UDPG_MGDP_dh_N PF03721.9 EDK40304.2 - 0.015 14.6 0.0 0.042 13.2 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.1 EDK40304.2 - 0.02 14.9 1.4 1 9.4 1.0 2.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.13 EDK40304.2 - 0.026 12.8 0.0 0.054 11.8 0.0 1.5 2 0 0 2 2 2 0 GDP dissociation inhibitor NAD_Gly3P_dh_N PF01210.18 EDK40304.2 - 0.051 13.3 0.1 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 EDK40304.2 - 0.053 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.16 EDK40304.2 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 ThiF family F420_oxidored PF03807.12 EDK40304.2 - 0.075 13.4 0.1 0.16 12.4 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 EDK40304.2 - 0.093 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HI0933_like PF03486.9 EDK40304.2 - 0.1 11.0 0.1 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein KR PF08659.5 EDK40304.2 - 0.16 11.6 0.4 5.9 6.5 0.1 2.6 2 0 0 2 2 2 0 KR domain W2 PF02020.13 EDK40305.2 - 2.3e-18 65.9 6.4 5e-18 64.8 4.4 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.18 EDK40305.2 - 4.1e-08 32.8 0.0 8.3e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 EDK40305.2 - 4.3e-08 32.2 16.4 0.0024 17.2 0.9 3.4 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 EDK40305.2 - 0.0024 17.9 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 EDK40305.2 - 0.036 13.6 14.1 0.035 13.6 0.6 3.7 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ctr PF04145.10 EDK40306.1 - 4.2e-27 94.9 14.0 1.3e-14 54.4 2.5 2.0 1 1 1 2 2 2 2 Ctr copper transporter family U3_assoc_6 PF08640.6 EDK40307.2 - 1.3e-30 104.9 4.6 6.8e-30 102.6 0.3 2.8 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.1 EDK40307.2 - 4.6e-06 26.7 0.7 0.024 15.2 0.1 3.6 1 1 1 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.5 EDK40307.2 - 9.4e-05 21.4 0.6 0.013 14.4 0.4 2.2 1 1 0 1 1 1 1 NRDE-2, necessary for RNA interference TPR_16 PF13432.1 EDK40307.2 - 0.00018 22.0 1.4 0.017 15.7 0.6 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 EDK40307.2 - 0.00033 20.6 0.5 1.5 9.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 EDK40307.2 - 0.024 14.2 0.2 0.48 10.1 0.1 2.6 1 1 2 3 3 3 0 TPR repeat TPR_19 PF14559.1 EDK40307.2 - 0.027 14.8 0.6 0.067 13.5 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat HAT PF02184.11 EDK40307.2 - 0.066 12.9 1.4 11 5.8 0.0 3.5 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat Suf PF05843.9 EDK40307.2 - 0.23 11.1 2.9 1.5 8.4 0.1 2.7 2 1 1 3 3 3 0 Suppressor of forked protein (Suf) SWIRM PF04433.12 EDK40309.2 - 4.5e-19 68.3 0.9 7.6e-18 64.4 0.0 2.9 3 0 0 3 3 3 1 SWIRM domain ZZ PF00569.12 EDK40309.2 - 6e-16 57.7 7.7 1.2e-15 56.8 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 EDK40309.2 - 3.4e-10 39.8 0.0 8.8e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 EDK40309.2 - 4e-07 30.0 0.3 1.3e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain DnaB_2 PF07261.6 EDK40309.2 - 0.21 11.1 1.7 0.45 10.1 0.1 2.3 3 0 0 3 3 3 0 Replication initiation and membrane attachment Baculo_IE-1 PF05290.6 EDK40309.2 - 0.74 9.5 5.2 1.7 8.3 3.6 1.6 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Ribosomal_S17e PF00833.13 EDK40310.1 - 3.8e-43 146.1 0.1 4.7e-43 145.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 Cryptochrome_C PF12546.3 EDK40310.1 - 0.039 14.6 0.1 0.051 14.2 0.0 1.2 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal DAO PF01266.19 EDK40311.2 - 7.5e-52 176.4 0.0 2.6e-51 174.6 0.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EDK40311.2 - 5.7e-05 23.0 0.0 0.00014 21.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 EDK40311.2 - 0.0055 15.8 0.1 0.0093 15.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Strep_67kDa_ant PF06100.6 EDK40311.2 - 0.01 14.2 1.3 0.028 12.7 0.2 1.9 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Pyr_redox_3 PF13738.1 EDK40311.2 - 0.06 13.3 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK40311.2 - 0.071 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 EDK40311.2 - 0.17 10.4 0.2 0.25 9.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase ATP-synt_S1 PF05827.7 EDK40312.2 - 9.4e-69 231.8 0.1 1.1e-68 231.6 0.1 1.0 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) CAP PF00188.21 EDK40313.2 - 1.7e-14 54.3 3.1 2.8e-14 53.6 2.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_M18 PF02127.10 EDK40314.2 - 9e-166 551.6 0.0 1e-165 551.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 EDK40314.2 - 9.8e-10 37.6 0.0 0.0005 18.9 0.0 2.6 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase AA_permease PF00324.16 EDK40315.2 - 2.4e-115 385.6 43.9 3e-115 385.3 30.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40315.2 - 1.1e-35 123.0 51.3 1.3e-35 122.7 35.6 1.1 1 0 0 1 1 1 1 Amino acid permease PrgI PF12666.2 EDK40315.2 - 0.047 13.8 0.4 0.047 13.8 0.3 3.9 6 0 0 6 6 6 0 PrgI family protein Synaptobrevin PF00957.16 EDK40315.2 - 1.3 8.7 0.0 1.3 8.7 0.0 4.0 5 0 0 5 5 5 0 Synaptobrevin Rad60-SLD PF11976.3 EDK40316.2 - 1.2e-20 72.9 0.3 2.3e-20 72.0 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like E2R135 PF11570.3 EDK40317.2 - 0.016 15.2 0.1 0.028 14.5 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 ThiF PF00899.16 EDK40319.1 - 1e-41 141.9 0.0 1.8e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 EDK40319.1 - 5.2e-24 83.6 0.1 1e-23 82.7 0.1 1.4 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 EDK40319.1 - 1.5e-16 60.7 0.0 4.2e-16 59.3 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.15 EDK40319.1 - 0.0078 16.3 0.0 0.023 14.7 0.0 1.8 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF2681 PF10883.3 EDK40319.1 - 0.012 15.7 0.6 0.023 14.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) HALZ PF02183.13 EDK40319.1 - 0.23 11.2 3.5 0.49 10.1 2.4 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper Mto2_bdg PF12808.2 EDK40319.1 - 0.43 10.7 3.5 0.98 9.5 2.4 1.6 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region NUC153 PF08159.7 EDK40320.2 - 4.9e-16 57.9 13.9 7.1e-16 57.4 1.7 3.5 3 0 0 3 3 3 2 NUC153 domain UreE_N PF02814.10 EDK40320.2 - 1.2 8.7 4.0 1.2 8.6 0.0 2.9 3 0 0 3 3 3 0 UreE urease accessory protein, N-terminal domain TLD PF07534.11 EDK40321.2 - 6.5e-28 97.4 0.1 4.5e-26 91.4 0.0 2.5 1 1 0 1 1 1 1 TLD Kei1 PF08552.6 EDK40322.2 - 6.5e-51 172.6 10.0 2.9e-50 170.5 6.9 1.8 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 DUF3816 PF12822.2 EDK40322.2 - 0.077 12.8 6.2 0.11 12.3 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) RIO1 PF01163.17 EDK40323.1 - 4e-73 244.8 4.6 4e-73 244.8 3.2 2.0 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 EDK40323.1 - 9.5e-07 28.2 0.2 9.5e-07 28.2 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 EDK40323.1 - 0.0024 17.6 0.0 0.28 10.8 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF2052 PF09747.4 EDK40324.2 - 0.021 14.7 1.8 0.025 14.5 1.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PAPS_reduct PF01507.14 EDK40324.2 - 0.064 13.0 0.3 0.066 13.0 0.2 1.2 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family KfrA_N PF11740.3 EDK40324.2 - 0.77 10.2 8.5 1.3 9.5 5.9 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term CART PF06373.6 EDK40325.2 - 0.33 10.9 4.5 0.68 9.9 3.1 1.6 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) LysE PF01810.13 EDK40326.2 - 0.15 11.2 4.4 0.2 10.9 3.0 1.5 1 1 0 1 1 1 0 LysE type translocator DUF3357 PF11837.3 EDK40326.2 - 0.45 10.3 0.1 0.45 10.3 0.1 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3357) DUF3169 PF11368.3 EDK40326.2 - 0.53 9.4 3.9 0.92 8.6 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DUF1129 PF06570.6 EDK40326.2 - 0.54 9.5 3.7 1.3 8.2 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) EmrE PF13536.1 EDK40326.2 - 1.2 9.3 8.1 0.13 12.4 1.2 2.3 1 1 0 2 2 2 0 Multidrug resistance efflux transporter HLH PF00010.21 EDK40327.2 - 1.4e-13 50.2 0.9 2.7e-13 49.3 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COP-gamma_platf PF08752.5 EDK40327.2 - 0.0013 18.5 0.3 0.0033 17.2 0.2 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Got1 PF04178.7 EDK40328.2 - 4.2e-31 107.5 15.5 4.2e-31 107.5 10.8 2.0 2 0 0 2 2 2 1 Got1/Sft2-like family PSS PF03034.10 EDK40328.2 - 0.082 12.2 6.8 0.015 14.7 0.9 2.2 1 1 1 2 2 2 0 Phosphatidyl serine synthase DUF2157 PF09925.4 EDK40328.2 - 7.1 6.2 10.5 0.3 10.6 0.2 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) HIT PF01230.18 EDK40329.1 - 2.2e-23 82.5 0.0 3.2e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 EDK40329.1 - 2.2e-10 40.7 0.0 3.4e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 EDK40329.1 - 0.0071 15.9 0.8 0.013 15.1 0.5 1.7 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Not1 PF04054.10 EDK40329.1 - 0.077 11.8 0.0 0.079 11.8 0.0 1.1 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 AAA PF00004.24 EDK40330.2 - 1.2e-97 323.1 0.0 1.8e-47 160.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 EDK40330.2 - 3.8e-20 71.6 1.5 1e-19 70.2 0.4 2.3 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 EDK40330.2 - 2.2e-14 53.7 0.0 1.2e-07 31.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 EDK40330.2 - 6.9e-14 51.4 0.1 4.6e-06 25.8 0.0 3.3 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 EDK40330.2 - 3e-12 46.6 0.0 1.5e-06 28.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 EDK40330.2 - 1.3e-11 45.3 0.0 0.0002 22.1 0.0 3.5 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.9 EDK40330.2 - 2e-11 43.7 0.9 1.9e-05 24.3 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 EDK40330.2 - 7.8e-11 42.2 3.6 0.0046 17.1 0.1 4.9 3 2 0 3 3 3 2 AAA domain CDC48_2 PF02933.12 EDK40330.2 - 1.3e-10 40.7 0.0 3.6e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.1 EDK40330.2 - 4.6e-10 39.7 0.4 0.0048 16.9 0.0 4.1 3 2 0 3 3 3 2 AAA ATPase domain TIP49 PF06068.8 EDK40330.2 - 1.5e-09 37.0 0.1 0.00068 18.4 0.0 2.6 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 EDK40330.2 - 1.7e-08 34.4 0.0 0.0012 18.7 0.0 2.8 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.12 EDK40330.2 - 9.3e-08 31.6 1.3 0.0053 16.2 0.1 3.0 4 0 0 4 4 2 2 IstB-like ATP binding protein RNA_helicase PF00910.17 EDK40330.2 - 3.1e-07 30.5 0.0 0.025 14.7 0.0 3.3 4 0 0 4 4 2 2 RNA helicase Mg_chelatase PF01078.16 EDK40330.2 - 4.5e-07 29.2 0.5 0.026 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 EDK40330.2 - 4.7e-07 29.1 0.0 0.0072 15.4 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin AAA_19 PF13245.1 EDK40330.2 - 5.8e-07 29.1 1.2 0.037 13.7 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 EDK40330.2 - 1.1e-06 28.2 8.5 0.065 12.6 0.4 4.5 2 2 2 4 4 4 2 AAA domain ResIII PF04851.10 EDK40330.2 - 2.8e-06 27.2 0.2 0.0027 17.5 0.0 2.6 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit AAA_18 PF13238.1 EDK40330.2 - 3.8e-06 27.2 0.0 0.15 12.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.1 EDK40330.2 - 7e-06 25.7 0.1 0.047 13.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 EDK40330.2 - 1.1e-05 25.4 0.0 0.23 11.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 EDK40330.2 - 1.2e-05 24.5 1.7 0.87 8.6 0.0 3.6 2 1 1 3 3 3 2 KaiC Vps4_C PF09336.5 EDK40330.2 - 1.2e-05 25.0 0.1 0.00067 19.4 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ABC_tran PF00005.22 EDK40330.2 - 1.9e-05 24.9 0.1 0.16 12.2 0.0 3.7 3 1 0 3 3 2 1 ABC transporter PhoH PF02562.11 EDK40330.2 - 3.3e-05 23.1 0.5 0.068 12.4 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activat PF00158.21 EDK40330.2 - 6.5e-05 22.4 0.1 0.28 10.6 0.0 3.4 3 1 0 3 3 2 1 Sigma-54 interaction domain AAA_11 PF13086.1 EDK40330.2 - 9e-05 22.1 0.0 0.34 10.4 0.0 2.7 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 EDK40330.2 - 0.0001 22.1 0.9 0.23 11.1 0.1 4.2 3 2 2 5 5 4 2 Archaeal ATPase DUF815 PF05673.8 EDK40330.2 - 0.00012 21.1 0.0 0.16 10.9 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Bac_DnaA PF00308.13 EDK40330.2 - 0.00015 21.4 0.0 0.052 13.1 0.0 2.8 2 0 0 2 2 2 1 Bacterial dnaA protein Sigma54_activ_2 PF14532.1 EDK40330.2 - 0.0002 21.4 0.0 0.96 9.4 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.12 EDK40330.2 - 0.00021 20.2 0.2 0.46 9.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_3 PF07726.6 EDK40330.2 - 0.00022 20.8 0.0 0.87 9.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 EDK40330.2 - 0.00039 20.1 0.3 3.7 7.1 0.0 3.6 3 0 0 3 3 3 0 NACHT domain DUF2075 PF09848.4 EDK40330.2 - 0.00058 18.9 0.0 0.6 9.0 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 EDK40330.2 - 0.0013 18.3 0.0 2 7.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 EDK40330.2 - 0.0029 16.5 0.7 1 8.1 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain NTPase_1 PF03266.10 EDK40330.2 - 0.0054 16.4 0.9 3.4 7.3 0.0 4.1 4 0 0 4 4 3 0 NTPase T2SE PF00437.15 EDK40330.2 - 0.0056 15.6 0.0 2.1 7.2 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein IPT PF01745.11 EDK40330.2 - 0.011 14.8 0.2 1.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_10 PF12846.2 EDK40330.2 - 0.012 15.0 0.9 13 5.1 0.1 3.7 3 1 1 4 4 4 0 AAA-like domain SMC_Nse1 PF07574.8 EDK40330.2 - 0.039 13.5 3.0 0.092 12.3 0.7 2.2 2 0 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex UPF0079 PF02367.12 EDK40330.2 - 0.052 13.1 0.2 12 5.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 SKI PF01202.17 EDK40330.2 - 0.059 13.2 0.0 4.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase KAP_NTPase PF07693.9 EDK40330.2 - 0.069 12.1 0.0 5.2 5.9 0.0 2.7 2 1 1 3 3 3 0 KAP family P-loop domain KTI12 PF08433.5 EDK40330.2 - 0.084 12.0 0.0 6.3 5.9 0.0 2.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Viral_helicase1 PF01443.13 EDK40330.2 - 0.12 11.8 0.0 14 5.0 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase MobB PF03205.9 EDK40330.2 - 1.2 8.8 3.8 34 4.1 0.1 3.7 4 0 0 4 4 3 0 Molybdopterin guanine dinucleotide synthesis protein B Glycos_transf_2 PF00535.21 EDK40331.2 - 1.6e-32 112.5 0.0 1.9e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 EDK40331.2 - 4.8e-14 52.7 0.0 5.6e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 EDK40331.2 - 2.3e-08 33.4 0.0 3e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 EDK40331.2 - 1.2e-05 24.7 0.0 1.8e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 EDK40331.2 - 0.085 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 ThiF PF00899.16 EDK40332.2 - 2.6e-34 117.9 0.0 5.2e-34 116.9 0.0 1.5 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 EDK40332.2 - 3.9e-26 90.4 0.4 8.7e-26 89.2 0.3 1.6 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 EDK40332.2 - 5.3e-20 70.5 6.3 5.3e-20 70.5 4.4 1.8 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 EDK40332.2 - 9.1e-07 28.8 2.3 1.6e-06 28.1 0.3 2.3 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Profilin PF00235.14 EDK40333.1 - 4.1e-41 139.8 0.0 4.6e-41 139.7 0.0 1.0 1 0 0 1 1 1 1 Profilin YugN PF08868.5 EDK40333.1 - 0.03 13.9 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 YugN-like family YCII PF03795.9 EDK40335.1 - 4.6e-05 23.5 0.0 5.6e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain YCII PF03795.9 EDK40336.1 - 0.00063 19.8 0.0 0.00081 19.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain zf-RanBP PF00641.13 EDK40337.2 - 4.7e-18 63.9 13.6 7.2e-11 40.9 1.6 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 EDK40337.2 - 7.1e-09 35.1 0.0 1.6e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.19 EDK40337.2 - 9.7e-09 35.7 0.1 2.8e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 Exonuclease RRM_6 PF14259.1 EDK40337.2 - 0.00037 20.4 0.0 0.00097 19.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 EDK40337.2 - 4.8 7.0 12.1 3.9 7.3 2.2 2.4 1 1 1 2 2 2 0 Double zinc ribbon Peptidase_S49_N PF08496.5 EDK40337.2 - 5.4 6.8 6.5 8.5 6.1 1.6 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF221 PF02714.10 EDK40338.2 - 1.5e-99 332.9 28.7 1.5e-99 332.9 19.9 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 EDK40338.2 - 2.9e-39 134.1 4.9 2.9e-39 134.1 3.4 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 EDK40338.2 - 0.0091 16.4 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) RRM_6 PF14259.1 EDK40338.2 - 0.035 14.0 0.0 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Zn_clus PF00172.13 EDK40339.2 - 1.2e-10 41.0 7.4 1.9e-10 40.4 5.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PX PF00787.19 EDK40340.2 - 6.5e-11 42.0 0.9 1.9e-10 40.5 0.1 2.0 2 0 0 2 2 2 1 PX domain SH3_1 PF00018.23 EDK40340.2 - 8.6e-09 34.6 0.0 1.8e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK40340.2 - 2.9e-08 33.1 0.0 5.4e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK40340.2 - 2.9e-06 26.6 0.0 6.8e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.6 EDK40340.2 - 0.018 15.2 1.0 0.29 11.3 0.3 2.9 2 1 0 2 2 2 0 Bacterial SH3 domain SH3_1 PF00018.23 EDK40341.2 - 2.9e-10 39.3 0.0 3.2e-09 36.0 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 EDK40341.2 - 2.5e-09 36.5 0.0 4.5e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PX PF00787.19 EDK40341.2 - 3.5e-08 33.2 0.1 3e-07 30.2 0.0 2.3 2 0 0 2 2 2 1 PX domain SH3_2 PF07653.12 EDK40341.2 - 0.00015 21.1 0.0 0.00095 18.6 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain Pkinase PF00069.20 EDK40343.2 - 3.7e-70 236.0 0.0 4.8e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40343.2 - 2.2e-36 125.2 0.0 2.9e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40343.2 - 3.9e-05 22.7 0.0 6.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.19 EDK40343.2 - 3.1 8.4 7.8 1.4 9.4 2.4 2.7 3 1 0 3 3 3 0 Protein kinase C terminal domain P22_Tail-4 PF11650.3 EDK40344.2 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 P22 tail accessory factor CRAL_TRIO PF00650.15 EDK40344.2 - 0.15 11.5 0.4 0.28 10.6 0.3 1.4 1 0 0 1 1 1 0 CRAL/TRIO domain NapE PF06796.6 EDK40344.2 - 1.2 8.5 4.5 3.5 7.0 3.1 1.8 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Peptidase_C12 PF01088.16 EDK40345.2 - 1.6e-53 181.0 0.0 1.8e-53 180.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SAC3_GANP PF03399.11 EDK40346.2 - 1.1e-56 191.6 5.7 1.1e-56 191.6 3.9 1.6 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 EDK40346.2 - 1.6e-05 24.7 0.4 5.3e-05 23.0 0.3 1.9 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 MRP-63 PF14978.1 EDK40346.2 - 2.9 8.3 8.1 2.3 8.7 0.5 3.2 3 0 0 3 3 3 0 Mitochondrial ribosome protein 63 TIM21 PF08294.6 EDK40347.2 - 0.061 12.9 0.1 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 TIM21 Sel1 PF08238.7 EDK40348.2 - 1.4e-08 35.0 0.7 0.0021 18.6 0.1 3.5 3 0 0 3 3 3 2 Sel1 repeat MAP1B_neuraxin PF00414.12 EDK40348.2 - 0.096 12.0 3.3 0.22 10.8 2.3 1.6 1 0 0 1 1 1 0 Neuraxin and MAP1B repeat Peptidase_M1 PF01433.15 EDK40349.2 - 6.1e-75 252.7 0.0 8.8e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 EDK40349.2 - 1.3e-41 141.5 2.2 2.1e-41 140.8 1.5 1.3 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 EDK40349.2 - 1.3e-18 67.2 0.0 2.1e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M48 PF01435.13 EDK40349.2 - 0.021 14.3 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M48 Ribosomal_S8 PF00410.14 EDK40350.1 - 3.3e-26 91.6 0.0 4.3e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1086 PF06461.6 EDK40351.2 - 0.044 13.5 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1086) DUF3445 PF11927.3 EDK40353.1 - 6.2e-76 255.0 0.9 7.8e-76 254.7 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) MFS_1 PF07690.11 EDK40354.2 - 9.9e-36 123.1 49.0 1.8e-23 82.8 18.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK40354.2 - 1e-07 30.9 46.0 1.2e-05 24.1 12.1 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.2 EDK40354.2 - 0.0053 16.5 4.8 0.12 12.1 0.6 2.6 2 0 0 2 2 2 2 MFS_1 like family Ion_trans_N PF08412.5 EDK40354.2 - 0.062 12.6 0.1 0.86 8.9 0.0 2.6 2 0 0 2 2 2 0 Ion transport protein N-terminal DUF2012 PF09430.5 EDK40355.2 - 1.6e-05 24.7 0.0 3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) TPT PF03151.11 EDK40356.2 - 1.3e-18 67.1 12.1 1.3e-18 67.1 8.4 3.4 2 2 0 2 2 2 1 Triose-phosphate Transporter family Beach PF02138.13 EDK40357.2 - 2e-107 358.6 0.2 7.6e-107 356.7 0.1 2.1 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.1 EDK40357.2 - 1.1e-12 47.6 0.0 3e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 EDK40357.2 - 4.6e-10 39.9 0.0 1.2e-09 38.6 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily UCH PF00443.24 EDK40358.2 - 3.6e-80 268.9 0.0 1.8e-79 266.6 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK40358.2 - 1e-19 71.0 0.1 3e-09 36.7 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase TSP9 PF11493.3 EDK40358.2 - 0.024 15.1 0.0 0.062 13.8 0.0 1.7 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 CW_binding_1 PF01473.15 EDK40358.2 - 0.24 11.5 1.9 0.75 10.0 1.3 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat TF_Zn_Ribbon PF08271.7 EDK40358.2 - 2.8 7.3 4.8 0.61 9.4 0.3 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding RNase_PH PF01138.16 EDK40359.2 - 2.7e-18 66.5 0.4 6.1e-17 62.1 0.3 2.3 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF3113 PF11310.3 EDK40359.2 - 0.011 15.4 0.7 0.4 10.4 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3113) RNase_PH_C PF03725.10 EDK40359.2 - 0.034 14.0 0.8 0.061 13.2 0.1 1.8 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Glu_synthase PF01645.12 EDK40360.2 - 1.3e-150 501.4 3.1 1.9e-132 441.6 0.5 2.7 3 0 0 3 3 3 2 Conserved region in glutamate synthase GATase_2 PF00310.16 EDK40360.2 - 2.9e-137 457.2 0.0 4.4e-137 456.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 EDK40360.2 - 8.5e-119 396.0 0.1 1.6e-118 395.1 0.1 1.5 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 EDK40360.2 - 2.6e-65 219.2 3.1 4.8e-65 218.3 2.1 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 EDK40360.2 - 2.5e-23 81.8 0.2 7.3e-23 80.3 0.2 1.9 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 EDK40360.2 - 1.8e-15 57.3 0.0 8.6e-15 55.1 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK40360.2 - 1.5e-10 41.4 0.3 0.00027 21.0 0.1 2.8 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK40360.2 - 1.4e-08 35.0 0.0 5.9e-05 23.3 0.0 3.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK40360.2 - 8.4e-08 32.1 0.0 3.1e-07 30.3 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 EDK40360.2 - 1.3e-05 24.5 0.1 2.3e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Hom_end PF05204.9 EDK40360.2 - 0.00017 21.5 1.9 0.062 13.2 0.0 4.0 4 0 0 4 4 3 1 Homing endonuclease FAD_binding_2 PF00890.19 EDK40360.2 - 0.00018 20.4 0.1 0.00037 19.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 EDK40360.2 - 0.00019 20.4 0.0 0.00045 19.2 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 EDK40360.2 - 0.00024 19.6 1.6 0.00028 19.4 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 EDK40360.2 - 0.00062 18.9 0.1 0.0028 16.7 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.2 EDK40360.2 - 0.0022 17.1 0.1 0.0047 16.0 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.1 EDK40360.2 - 0.003 17.8 1.3 0.97 9.7 0.0 3.5 3 0 0 3 3 3 1 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.18 EDK40360.2 - 0.0034 17.1 0.0 0.0081 15.9 0.0 1.7 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 EDK40360.2 - 0.004 16.2 0.1 0.009 15.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain LAGLIDADG_3 PF14528.1 EDK40360.2 - 0.0041 17.3 0.1 0.068 13.4 0.0 2.7 2 0 0 2 2 2 1 LAGLIDADG-like domain AlaDh_PNT_C PF01262.16 EDK40360.2 - 0.015 14.8 0.5 0.11 12.0 0.1 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Hom_end_hint PF05203.11 EDK40360.2 - 0.017 14.8 0.4 0.041 13.6 0.0 1.8 2 0 0 2 2 1 0 Hom_end-associated Hint AdoHcyase_NAD PF00670.16 EDK40360.2 - 0.033 14.0 0.1 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Hint_2 PF13403.1 EDK40360.2 - 0.078 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Hint domain FMO-like PF00743.14 EDK40360.2 - 0.13 10.3 0.0 0.82 7.7 0.0 2.0 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like Shikimate_DH PF01488.15 EDK40360.2 - 0.16 12.1 1.3 25 4.9 0.0 2.9 3 0 0 3 3 2 0 Shikimate / quinate 5-dehydrogenase Fasciclin PF02469.17 EDK40362.2 - 1.8e-05 24.7 0.0 4.9e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Fasciclin domain GrpB PF04229.9 EDK40362.2 - 0.0058 16.3 0.2 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 GrpB protein DUF4469 PF14734.1 EDK40362.2 - 0.028 14.2 0.1 0.074 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold VHS PF00790.14 EDK40363.2 - 2e-40 137.6 0.0 4.8e-40 136.4 0.0 1.6 1 0 0 1 1 1 1 VHS domain Alpha_adaptinC2 PF02883.15 EDK40363.2 - 2e-17 63.5 0.9 2e-17 63.5 0.6 2.2 1 1 1 2 2 2 1 Adaptin C-terminal domain GAT PF03127.9 EDK40363.2 - 2.9e-13 49.6 0.7 1.2e-12 47.6 0.5 2.2 1 0 0 1 1 1 1 GAT domain Phage_cap_E PF03864.10 EDK40363.2 - 0.043 12.7 0.1 0.069 12.0 0.1 1.2 1 0 0 1 1 1 0 Phage major capsid protein E Seryl_tRNA_N PF02403.17 EDK40363.2 - 0.4 10.7 5.9 1.3 9.0 1.6 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4112 PF13430.1 EDK40364.1 - 1.1e-33 115.2 0.5 1.5e-33 114.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Coq4 PF05019.8 EDK40365.2 - 5.2e-101 336.1 0.0 6.4e-101 335.8 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GyrI-like PF06445.10 EDK40365.2 - 0.027 14.4 0.2 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 GyrI-like small molecule binding domain Antimicrobial_5 PF08026.6 EDK40365.2 - 0.064 13.1 0.2 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Bee antimicrobial peptide FHA PF00498.21 EDK40366.2 - 7.7e-16 57.9 0.0 1.4e-13 50.7 0.0 2.5 2 0 0 2 2 2 2 FHA domain YjgP_YjgQ PF03739.9 EDK40366.2 - 0.01 14.5 1.2 0.015 14.1 0.8 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family AT_hook PF02178.14 EDK40366.2 - 0.18 11.5 7.3 1.9 8.4 0.8 2.6 2 0 0 2 2 2 0 AT hook motif DASH_Spc19 PF08287.6 EDK40367.2 - 1.4e-43 148.1 7.6 1.8e-43 147.8 5.3 1.1 1 0 0 1 1 1 1 Spc19 PMEI PF04043.10 EDK40367.2 - 0.047 13.5 2.3 0.11 12.4 0.0 2.2 2 1 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Spc24 PF08286.6 EDK40367.2 - 0.35 10.5 2.9 6.8 6.4 0.2 2.6 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Sec2p PF06428.6 EDK40367.2 - 0.48 10.2 5.3 6.6 6.6 2.3 2.4 1 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p PXA PF02194.10 EDK40368.2 - 1.3e-13 50.9 3.7 3.1e-13 49.6 2.5 1.7 1 0 0 1 1 1 1 PXA domain BPL_LplA_LipB PF03099.14 EDK40369.2 - 1.7e-12 47.4 0.0 3.7e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family TMF_DNA_bd PF12329.3 EDK40369.2 - 0.0071 16.1 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding Rotamase PF00639.16 EDK40369.2 - 0.024 15.3 1.3 47 4.8 0.1 3.2 2 1 1 3 3 3 0 PPIC-type PPIASE domain YdjC PF04794.7 EDK40369.2 - 0.086 12.2 0.0 0.43 10.0 0.0 1.9 2 0 0 2 2 2 0 YdjC-like protein SAS4 PF15460.1 EDK40370.2 - 0.049 13.5 0.1 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 BCL_N PF04714.8 EDK40370.2 - 0.14 11.7 0.5 0.31 10.6 0.4 1.6 1 0 0 1 1 1 0 BCL7, N-terminal conserver region CybS PF05328.7 EDK40371.1 - 4.4e-54 181.6 0.2 6.1e-54 181.2 0.1 1.2 1 0 0 1 1 1 1 CybS TPR_14 PF13428.1 EDK40372.2 - 0.019 15.5 0.2 0.24 12.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 EDK40372.2 - 0.022 15.0 0.0 0.065 13.5 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-DHHC PF01529.15 EDK40373.2 - 2.2e-34 118.3 11.5 2.2e-34 118.3 8.0 1.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF2157 PF09925.4 EDK40373.2 - 0.37 10.3 4.7 0.072 12.7 0.4 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Nipped-B_C PF12830.2 EDK40374.2 - 2.3e-39 134.9 6.4 9.1e-39 133.0 1.4 3.3 2 1 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 EDK40374.2 - 1.5e-13 50.4 7.3 7.7e-13 48.0 1.1 3.7 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Metallophos PF00149.23 EDK40375.2 - 1.6e-09 37.4 2.5 4e-09 36.1 1.7 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SAS4 PF15460.1 EDK40376.2 - 1.8e-32 111.1 0.3 3.6e-32 110.2 0.2 1.5 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Sec10 PF07393.6 EDK40377.2 - 2e-189 631.2 17.3 2.5e-189 630.9 12.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF16 PF01519.11 EDK40377.2 - 0.0049 17.0 0.5 0.0049 17.0 0.3 2.5 2 0 0 2 2 2 1 Protein of unknown function DUF16 TMF_DNA_bd PF12329.3 EDK40377.2 - 0.038 13.8 1.5 0.41 10.4 0.1 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Nnf1 PF03980.9 EDK40377.2 - 0.057 13.4 2.0 0.24 11.4 0.2 2.7 2 0 0 2 2 2 0 Nnf1 ubiquitin PF00240.18 EDK40378.1 - 1.3e-34 117.4 0.9 2.6e-34 116.4 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.14 EDK40378.1 - 1.8e-27 94.9 2.1 3.3e-27 94.0 1.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 EDK40378.1 - 4.8e-20 71.0 0.7 1e-19 70.0 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 EDK40378.1 - 7.9e-06 26.0 0.4 3.8e-05 23.8 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 EDK40378.1 - 0.00011 21.9 0.0 0.00017 21.3 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 EDK40378.1 - 0.0012 18.6 0.4 0.0026 17.6 0.3 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 EDK40378.1 - 0.0054 16.9 0.5 0.0072 16.4 0.4 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.16 EDK40378.1 - 0.024 14.4 0.5 0.037 13.9 0.4 1.3 1 0 0 1 1 1 0 IBR domain DUF2870 PF11069.3 EDK40378.1 - 0.044 13.8 0.3 0.092 12.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Plexin_cytopl PF08337.7 EDK40378.1 - 0.16 10.2 2.9 3.5 5.8 0.1 2.2 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain PRELI PF04707.9 EDK40379.2 - 2.7e-52 176.4 0.1 3.9e-52 175.9 0.1 1.2 1 0 0 1 1 1 1 PRELI-like family DDE_1 PF03184.14 EDK40380.2 - 8.7e-10 38.0 0.0 2.1e-09 36.8 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease LicD PF04991.8 EDK40382.2 - 1.5e-43 149.3 2.7 1.5e-43 149.3 1.9 2.4 2 1 0 2 2 2 1 LicD family Peptidase_M16 PF00675.15 EDK40383.2 - 1.1e-49 168.0 0.0 3e-48 163.3 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EDK40383.2 - 1.5e-32 112.7 0.0 5.1e-32 111.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Ada3 PF10198.4 EDK40384.2 - 1.8e-44 150.6 5.1 3.9e-44 149.5 3.6 1.5 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 MRP-S28 PF10213.4 EDK40385.2 - 1.3e-39 135.2 1.7 2.3e-39 134.3 1.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein DUF159 PF02586.9 EDK40386.2 - 1.9e-41 141.9 0.3 3.4e-41 141.0 0.2 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 MgsA_C PF12002.3 EDK40387.2 - 1.7e-57 193.8 0.0 4.4e-57 192.4 0.0 1.7 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal zf-C2HC_2 PF13913.1 EDK40388.2 - 0.0013 18.3 1.8 0.0021 17.6 1.2 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.1 EDK40388.2 - 0.058 13.7 0.6 0.14 12.5 0.4 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 EDK40388.2 - 0.063 13.6 0.4 0.15 12.5 0.3 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type GRA6 PF05084.8 EDK40388.2 - 0.7 9.3 4.2 1.1 8.7 2.6 1.5 1 1 0 1 1 1 0 Granule antigen protein (GRA6) OGG_N PF07934.7 EDK40389.2 - 1.6e-32 111.9 0.5 3.6e-32 110.7 0.4 1.6 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 EDK40389.2 - 3.1e-15 56.3 0.0 5.2e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 EDK40389.2 - 0.038 13.7 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Zn_clus PF00172.13 EDK40390.2 - 8.8e-06 25.5 9.0 1.9e-05 24.4 6.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK40390.2 - 1.2e-05 24.3 3.1 3.5e-05 22.7 2.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3463 PF11946.3 EDK40390.2 - 0.069 12.7 2.2 1.6 8.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3463) Fungal_trans PF04082.13 EDK40391.2 - 3.9e-10 39.0 0.1 6.9e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Arylsulfotran_2 PF14269.1 EDK40392.2 - 9.8e-89 297.4 7.8 1.4e-88 296.9 5.4 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ PF01011.16 EDK40392.2 - 0.028 13.9 1.3 2 8.1 0.1 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat Arylsulfotran_2 PF14269.1 EDK40393.2 - 1.8e-77 260.4 3.5 2.4e-77 260.0 2.4 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 EDK40393.2 - 3e-18 65.5 1.8 8e-18 64.1 1.0 1.8 1 1 1 2 2 2 1 Arylsulfotransferase (ASST) PQQ PF01011.16 EDK40393.2 - 0.019 14.5 0.1 1.6 8.3 0.1 3.2 2 0 0 2 2 2 0 PQQ enzyme repeat MFS_1 PF07690.11 EDK40394.2 - 2.6e-40 138.2 41.6 5e-40 137.3 28.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK40395.2 - 7e-28 97.3 14.8 9.9e-28 96.8 10.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4281 PF14108.1 EDK40395.2 - 0.015 15.4 1.2 0.042 13.9 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4281) MFS_1 PF07690.11 EDK40396.2 - 2.8e-21 75.6 14.4 3.4e-21 75.3 10.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 EDK40396.2 - 0.013 15.2 0.5 0.038 13.7 0.4 1.8 1 0 0 1 1 1 0 MFS_1 like family SdpI PF13630.1 EDK40396.2 - 1.4 8.6 7.5 3.5 7.3 1.0 2.7 2 0 0 2 2 2 0 SdpI/YhfL protein family AHS2 PF02626.10 EDK40398.2 - 1.4e-66 224.6 0.0 1.9e-66 224.1 0.0 1.2 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 CPSase_L_D2 PF02786.12 EDK40398.2 - 6.7e-44 149.7 0.0 1.2e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 EDK40398.2 - 4.7e-30 103.7 0.0 7.7e-30 103.0 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain AHS1 PF02682.11 EDK40398.2 - 3.2e-14 52.8 0.0 6e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 ATP-grasp_4 PF13535.1 EDK40398.2 - 4.6e-08 33.0 0.1 8.2e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EDK40398.2 - 1.4e-06 27.8 0.0 2.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 EDK40398.2 - 0.0035 16.1 0.0 0.0058 15.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon LamB_YcsF PF03746.11 EDK40399.2 - 5.8e-70 235.1 0.0 6.9e-70 234.8 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family AP_endonuc_2 PF01261.19 EDK40399.2 - 0.088 12.0 0.0 7.6 5.7 0.0 2.3 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel SSF PF00474.12 EDK40400.2 - 1.3e-09 37.1 7.7 1.3e-09 37.1 5.3 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family SSF PF00474.12 EDK40401.2 - 1.2e-09 37.3 8.8 1.2e-09 37.3 6.1 1.5 1 1 0 1 1 1 1 Sodium:solute symporter family DUF1785 PF08699.5 EDK40401.2 - 0.1 11.9 0.2 0.24 10.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1785) AA_permease PF00324.16 EDK40402.1 - 1.6e-97 326.8 34.3 2e-97 326.5 23.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40402.1 - 2.5e-22 78.9 36.2 3.4e-22 78.5 25.1 1.0 1 0 0 1 1 1 1 Amino acid permease DHDPS PF00701.17 EDK40403.1 - 3.7e-70 235.7 0.0 4.2e-70 235.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Peripla_BP_1 PF00532.16 EDK40403.1 - 0.037 13.2 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family PEP_mutase PF13714.1 EDK40403.1 - 0.076 12.2 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Fungal_trans PF04082.13 EDK40405.2 - 4.4e-26 91.3 0.7 1.1e-25 90.0 0.5 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40405.2 - 9.2e-11 41.4 8.4 1.8e-10 40.5 5.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FMN_dh PF01070.13 EDK40406.2 - 8.1e-118 393.3 0.0 1.2e-117 392.7 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 EDK40406.2 - 3.5e-07 29.7 0.1 6.6e-05 22.2 0.0 2.6 2 1 1 3 3 3 2 Histidine biosynthesis protein IMPDH PF00478.20 EDK40406.2 - 1e-06 27.8 0.2 3e-06 26.3 0.1 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 EDK40406.2 - 2.8e-06 26.5 0.2 1.5e-05 24.0 0.1 1.9 1 1 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 EDK40406.2 - 9.5e-06 24.9 0.5 1.7e-05 24.1 0.2 1.4 2 0 0 2 2 2 1 Nitronate monooxygenase ThiG PF05690.9 EDK40406.2 - 0.00024 20.2 0.6 0.042 12.9 0.0 2.4 1 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG DHO_dh PF01180.16 EDK40406.2 - 0.0066 15.4 0.2 0.31 9.9 0.0 2.1 1 1 0 2 2 2 1 Dihydroorotate dehydrogenase Dus PF01207.12 EDK40406.2 - 0.02 13.7 0.1 5.1 5.8 0.0 2.3 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) Aldedh PF00171.17 EDK40407.1 - 1.4e-103 346.7 0.2 1.7e-103 346.4 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 EDK40407.1 - 0.021 13.5 0.0 0.029 13.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) BMC PF00936.14 EDK40407.1 - 0.085 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 BMC domain Aldedh PF00171.17 EDK40408.1 - 4.2e-57 193.5 0.1 4.6e-57 193.3 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Zn_clus PF00172.13 EDK40409.2 - 3.8e-09 36.3 11.3 8.2e-09 35.2 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 EDK40410.2 - 6.6e-73 245.8 18.6 8.1e-73 245.5 12.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40410.2 - 2.2e-22 79.2 44.8 1.8e-21 76.2 16.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK40410.2 - 0.0004 18.8 26.7 0.0092 14.4 5.9 2.8 2 2 1 3 3 3 2 MFS/sugar transport protein DUF3671 PF12420.3 EDK40410.2 - 6.3 6.8 6.5 1.6 8.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF1680 PF07944.7 EDK40411.2 - 2e-105 353.0 0.0 3.5e-105 352.2 0.0 1.3 1 1 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) ASL_C2 PF14698.1 EDK40411.2 - 0.06 13.4 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Argininosuccinate lyase C-terminal INTS5_N PF14837.1 EDK40412.2 - 0.04 13.3 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus YL1 PF05764.8 EDK40412.2 - 6.6 6.2 11.4 0.21 11.1 3.6 1.6 2 0 0 2 2 2 0 YL1 nuclear protein UPF0047 PF01894.12 EDK40413.1 - 8.4e-42 141.7 0.0 9.8e-42 141.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PHD PF00628.24 EDK40414.2 - 1.4e-10 40.7 6.4 3.5e-10 39.4 4.4 1.7 1 0 0 1 1 1 1 PHD-finger Matrilin_ccoil PF10393.4 EDK40414.2 - 0.053 12.8 0.0 0.14 11.5 0.0 1.8 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin MFS_1 PF07690.11 EDK40415.2 - 1e-18 67.1 45.4 4.3e-15 55.2 30.1 2.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.8 EDK40415.2 - 2.1e-06 26.1 4.9 4.2e-06 25.1 3.4 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector TRI12 PF06609.8 EDK40415.2 - 2.6e-05 22.6 29.0 0.001 17.3 20.1 2.9 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF872 PF05915.7 EDK40415.2 - 0.0033 17.2 0.1 0.021 14.6 0.1 2.5 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) WD40 PF00400.27 EDK40416.2 - 1.7e-16 59.3 8.5 0.00074 19.3 0.0 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 EDK40416.2 - 3.5e-10 39.6 0.1 1.5e-09 37.5 0.0 2.1 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex Cellulase-like PF12876.2 EDK40416.2 - 0.089 13.2 0.1 1.7 9.1 0.0 2.9 2 1 0 2 2 2 0 Sugar-binding cellulase-like Vps55 PF04133.9 EDK40417.2 - 7.7e-34 116.0 2.6 9.7e-34 115.6 1.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Oxidored_q1 PF00361.15 EDK40417.2 - 0.012 14.8 1.3 0.012 14.8 0.9 1.9 2 0 0 2 2 2 0 NADH-Ubiquinone/plastoquinone (complex I), various chains LGT PF01790.13 EDK40417.2 - 0.014 14.3 2.5 1.8 7.4 0.1 2.2 1 1 1 2 2 2 0 Prolipoprotein diacylglyceryl transferase EI24 PF07264.6 EDK40417.2 - 0.025 14.0 6.0 0.075 12.4 4.2 1.7 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Oxidored_q2 PF00420.19 EDK40417.2 - 0.04 13.5 3.0 0.45 10.1 0.3 2.2 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L ABC2_membrane_5 PF13346.1 EDK40417.2 - 0.57 9.4 12.4 0.12 11.6 3.3 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF1516 PF07457.6 EDK40417.2 - 6.6 6.8 8.7 5.5 7.1 1.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1516) Abi PF02517.11 EDK40417.2 - 6.8 6.9 9.7 45 4.2 6.7 2.2 1 1 0 1 1 1 0 CAAX protease self-immunity DUF1077 PF06417.7 EDK40418.1 - 3e-51 171.9 4.4 3.6e-51 171.7 3.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) THUMP PF02926.12 EDK40419.1 - 4.6e-22 78.4 0.5 4.6e-22 78.4 0.3 2.1 2 0 0 2 2 2 1 THUMP domain DUF1357 PF07094.6 EDK40419.1 - 3.4 7.0 16.0 0.078 12.4 1.9 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1357) F-box PF00646.28 EDK40420.2 - 0.00058 19.4 0.1 0.0017 17.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 EDK40420.2 - 0.03 14.0 0.3 0.088 12.5 0.1 2.0 2 0 0 2 2 2 0 F-box-like HSP70 PF00012.15 EDK40421.2 - 4.4e-225 748.1 5.9 5.6e-225 747.8 4.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EDK40421.2 - 8e-19 67.3 2.6 1.9e-17 62.9 0.6 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 EDK40421.2 - 5.6e-05 22.8 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 EDK40421.2 - 0.0025 17.6 7.4 1.3 8.8 0.1 4.6 4 1 0 4 4 4 2 Cell division protein FtsA Hydantoinase_A PF01968.13 EDK40421.2 - 0.011 14.8 2.0 1.2 8.1 0.2 3.2 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase Proteasome PF00227.21 EDK40422.2 - 6e-50 169.1 0.3 9.1e-50 168.5 0.2 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EDK40422.2 - 1.3e-11 43.6 0.1 2.1e-11 42.9 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Phage_CRI PF05144.9 EDK40422.2 - 0.0098 15.0 0.1 0.019 14.0 0.0 1.4 1 0 0 1 1 1 1 Phage replication protein CRI Sec15 PF04091.7 EDK40423.2 - 3.3e-103 345.2 2.1 3.3e-103 345.2 1.5 2.9 2 1 1 3 3 3 1 Exocyst complex subunit Sec15-like Sec5 PF15469.1 EDK40423.2 - 0.00041 20.1 4.8 0.0021 17.8 3.3 2.2 1 0 0 1 1 1 1 Exocyst complex component Sec5 Sec8_exocyst PF04048.9 EDK40423.2 - 0.0033 17.0 3.6 0.012 15.2 2.5 2.0 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DASH_Duo1 PF08651.5 EDK40423.2 - 0.058 12.9 4.2 0.11 12.1 1.3 2.7 1 1 1 2 2 2 0 DASH complex subunit Duo1 DUF869 PF05911.6 EDK40423.2 - 4.4 5.4 11.1 2.4 6.2 5.8 1.7 1 1 0 2 2 2 0 Plant protein of unknown function (DUF869) Adaptin_binding PF10199.4 EDK40424.2 - 3.6e-13 49.9 7.3 1.6e-12 47.8 5.0 2.0 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 DUF3952 PF13130.1 EDK40424.2 - 0.084 12.8 1.2 0.16 11.9 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3952) Dynamin_N PF00350.18 EDK40425.2 - 1.2e-15 57.7 1.5 3.2e-15 56.3 0.0 2.6 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 EDK40425.2 - 4e-10 39.6 0.2 1e-08 35.1 0.0 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK40425.2 - 5.1e-09 35.8 1.1 3.4e-06 26.6 1.3 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain PglZ PF08665.7 EDK40425.2 - 0.0033 17.1 0.3 0.0033 17.1 0.2 3.0 4 0 0 4 4 4 1 PglZ domain Miro PF08477.8 EDK40425.2 - 0.0056 17.1 1.6 0.23 11.9 0.1 3.5 2 1 0 2 2 2 1 Miro-like protein AAA_17 PF13207.1 EDK40425.2 - 0.046 14.5 0.8 1.1 10.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 EDK40425.2 - 0.049 13.9 0.7 2 8.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.1 EDK40425.2 - 0.1 12.1 0.3 0.39 10.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF1904 PF08921.6 EDK40425.2 - 0.56 10.2 5.9 7.2 6.7 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1904) Ureidogly_hydro PF04115.7 EDK40426.2 - 1.5e-50 170.8 0.1 1.7e-50 170.6 0.1 1.0 1 0 0 1 1 1 1 Ureidoglycolate hydrolase adh_short PF00106.20 EDK40427.2 - 1e-23 84.0 0.1 1.4e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK40427.2 - 2.3e-17 63.5 0.5 2.8e-17 63.3 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK40427.2 - 8.6e-13 48.3 0.1 1.2e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK40427.2 - 9.6e-07 28.9 1.0 1.6e-06 28.2 0.7 1.6 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK40427.2 - 0.00021 20.7 0.1 0.00043 19.7 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 EDK40427.2 - 0.00025 21.0 0.1 0.0016 18.4 0.1 2.0 2 0 0 2 2 2 1 TrkA-N domain Saccharop_dh PF03435.13 EDK40427.2 - 0.0078 15.2 0.1 0.012 14.6 0.1 1.4 1 1 0 1 1 1 1 Saccharopine dehydrogenase DUF1776 PF08643.5 EDK40427.2 - 0.022 13.9 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Methyltransf_18 PF12847.2 EDK40427.2 - 0.039 14.5 0.0 0.095 13.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain NmrA PF05368.8 EDK40427.2 - 0.055 12.7 0.3 0.12 11.5 0.1 1.5 1 1 0 1 1 1 0 NmrA-like family Semialdhyde_dh PF01118.19 EDK40427.2 - 0.11 12.8 0.1 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Peripla_BP_6 PF13458.1 EDK40427.2 - 0.12 11.7 0.4 4.1 6.6 0.0 2.0 1 1 1 2 2 2 0 Periplasmic binding protein Nodulin-like PF06813.8 EDK40428.2 - 4.9e-18 65.3 5.6 4.9e-18 65.3 3.9 2.0 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.11 EDK40428.2 - 2.3e-16 59.4 21.4 2.3e-16 59.4 14.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UBX PF00789.15 EDK40429.2 - 5.4e-12 45.6 0.0 1.7e-11 44.0 0.0 1.9 1 0 0 1 1 1 1 UBX domain Prenyltrans PF00432.16 EDK40430.2 - 6.1e-38 128.0 11.3 9.7e-11 41.0 0.0 5.0 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EDK40430.2 - 3.1e-18 66.2 0.1 9.8e-12 45.2 0.0 3.4 2 1 1 3 3 3 2 Prenyltransferase-like Prenyltrans_1 PF13243.1 EDK40430.2 - 0.0065 16.4 0.0 0.88 9.6 0.0 3.2 2 1 1 3 3 3 2 Prenyltransferase-like Y_phosphatase PF00102.22 EDK40431.2 - 4.4e-58 196.3 1.9 6.5e-58 195.8 1.3 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 EDK40431.2 - 9.6e-20 71.0 0.0 8.3e-18 64.7 0.0 3.1 3 0 0 3 3 3 1 Rhodanese-like domain DSPc PF00782.15 EDK40431.2 - 0.0001 21.8 0.0 0.0005 19.6 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 EDK40431.2 - 0.013 15.5 0.0 0.042 13.8 0.0 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 EDK40431.2 - 0.035 14.3 0.0 0.068 13.4 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family HAUS5 PF14817.1 EDK40432.2 - 0.0023 16.5 13.2 0.0029 16.2 9.1 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Effector_1 PF04518.7 EDK40432.2 - 0.025 13.5 7.0 0.037 13.0 4.9 1.3 1 0 0 1 1 1 0 Effector from type III secretion system CENP-H PF05837.7 EDK40432.2 - 0.22 11.6 21.7 1.9 8.7 7.6 3.4 2 1 1 3 3 3 0 Centromere protein H (CENP-H) TSC22 PF01166.13 EDK40432.2 - 0.44 10.5 8.8 4.3 7.3 0.5 4.0 3 2 1 4 4 4 0 TSC-22/dip/bun family IncA PF04156.9 EDK40432.2 - 1 8.8 27.6 1.8 8.1 19.1 1.5 1 1 0 1 1 1 0 IncA protein DUF4200 PF13863.1 EDK40432.2 - 4.6 7.1 25.6 0.42 10.5 10.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF2418 PF10332.4 EDK40433.2 - 6.3e-31 106.6 0.4 6.3e-31 106.6 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) RNase_PH PF01138.16 EDK40434.2 - 8e-17 61.7 0.0 1.1e-16 61.2 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 EDK40434.2 - 0.0028 17.5 0.0 0.0063 16.4 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 G-7-MTase PF12803.2 EDK40434.2 - 0.021 13.9 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Nup35_RRM PF05172.8 EDK40435.2 - 3.1e-24 84.6 0.0 7.4e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 EDK40435.2 - 6.4e-05 22.6 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SpoU_methylase PF00588.14 EDK40436.2 - 9.8e-26 90.3 0.0 2.4e-25 89.0 0.0 1.7 1 0 0 1 1 1 1 SpoU rRNA Methylase family DUF3445 PF11927.3 EDK40437.2 - 5.1e-78 261.9 0.1 6.2e-78 261.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) PX PF00787.19 EDK40438.2 - 8.6e-20 70.6 1.0 6.7e-19 67.7 0.0 2.4 2 1 0 2 2 2 1 PX domain Snapin_Pallidin PF14712.1 EDK40438.2 - 3.8 7.8 8.8 8.9 6.6 0.4 3.4 4 0 0 4 4 4 0 Snapin/Pallidin Nup84_Nup100 PF04121.8 EDK40439.2 - 2.2e-241 802.4 2.5 2.6e-241 802.1 1.7 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Nup96 PF12110.3 EDK40439.2 - 0.004 16.2 1.7 0.85 8.6 0.0 3.6 4 0 0 4 4 4 2 Nuclear protein 96 PCI PF01399.22 EDK40440.2 - 5.6e-17 61.9 3.0 8.7e-17 61.3 0.1 2.7 3 1 0 3 3 3 1 PCI domain TPR_21 PF09976.4 EDK40440.2 - 8.6e-05 22.5 7.0 0.19 11.6 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 EDK40440.2 - 0.00047 19.7 5.3 20 5.3 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 EDK40440.2 - 0.00071 20.1 3.2 0.56 10.9 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.1 EDK40440.2 - 0.0023 17.1 10.5 0.0067 15.6 0.5 2.6 2 1 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 EDK40440.2 - 0.014 15.3 11.0 0.71 9.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 EDK40440.2 - 0.017 15.5 13.5 0.48 10.9 0.6 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Apc5 PF12862.2 EDK40440.2 - 0.02 14.7 3.1 0.53 10.1 0.2 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_8 PF13181.1 EDK40440.2 - 0.054 13.2 9.6 5.3 7.0 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DDRGK PF09756.4 EDK40440.2 - 0.061 12.7 0.5 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 DDRGK domain TPR_20 PF14561.1 EDK40440.2 - 0.77 9.9 5.1 4.3 7.5 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Methyltransf_23 PF13489.1 EDK40441.2 - 2.5e-16 59.8 0.0 5.5e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK40441.2 - 2.6e-13 49.8 0.0 5.3e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK40441.2 - 4e-12 46.4 0.0 8.6e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK40441.2 - 1.5e-11 44.5 0.3 3.9e-11 43.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK40441.2 - 6.4e-11 41.8 0.0 1.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EDK40441.2 - 2.2e-10 40.7 0.0 5.3e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40441.2 - 1.2e-09 38.6 0.0 2.6e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK40441.2 - 0.0045 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK40441.2 - 0.055 12.8 1.0 0.22 10.8 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase small domain DivIC PF04977.10 EDK40442.2 - 0.064 12.7 3.3 0.25 10.8 0.3 2.1 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.7 EDK40442.2 - 3.6 8.0 5.5 8.1 6.9 0.3 2.1 1 1 1 2 2 2 0 SlyX RF-1 PF00472.15 EDK40443.2 - 1.3e-37 128.0 1.8 1.3e-37 128.0 1.3 1.7 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.13 EDK40443.2 - 5.8e-28 96.9 0.0 1.3e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 PCRF domain TBCA PF02970.11 EDK40443.2 - 0.37 10.8 4.7 0.12 12.4 0.5 2.2 2 0 0 2 2 2 0 Tubulin binding cofactor A EMP24_GP25L PF01105.19 EDK40444.2 - 1.9e-46 158.0 3.5 2.8e-46 157.5 2.4 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD XLF PF09302.6 EDK40444.2 - 0.028 14.1 0.4 0.21 11.3 0.1 2.1 2 0 0 2 2 2 0 XLF (XRCC4-like factor) ECR1_N PF14382.1 EDK40445.2 - 5.5e-14 51.1 0.0 2.5e-13 49.0 0.0 2.2 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 EDK40445.2 - 0.0051 16.7 0.0 0.2 11.6 0.0 2.9 2 1 0 2 2 2 1 Exosome component EXOSC1/CSL4 Met_10 PF02475.11 EDK40446.2 - 4.6e-70 235.2 0.0 7.7e-70 234.5 0.0 1.4 1 1 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.10 EDK40446.2 - 0.00049 19.6 0.0 0.00081 18.9 0.0 1.3 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.11 EDK40446.2 - 0.019 13.8 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase BHD_3 PF10405.4 EDK40447.2 - 2.5e-23 81.5 0.1 5.4e-23 80.4 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.10 EDK40447.2 - 7.5e-21 74.0 0.7 4.5e-20 71.5 0.0 2.7 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_1 PF10403.4 EDK40447.2 - 6.8e-17 60.7 2.4 2.4e-16 58.9 0.2 2.7 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 EDK40447.2 - 9.4e-06 25.8 4.0 1.9e-05 24.8 0.2 3.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 DUF3420 PF11900.3 EDK40447.2 - 0.1 12.7 1.6 0.34 11.0 1.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) BUD22 PF09073.5 EDK40447.2 - 0.17 10.9 0.0 0.17 10.9 0.0 2.5 3 0 0 3 3 3 0 BUD22 RNase_H2_suC PF08615.6 EDK40448.2 - 2.5e-28 98.6 0.0 2.8e-28 98.4 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) VirE PF05272.6 EDK40448.2 - 0.068 12.6 0.0 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Virulence-associated protein E DIOX_N PF14226.1 EDK40449.2 - 5.4e-15 55.9 0.0 9.7e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 EDK40449.2 - 1.9e-13 50.5 0.0 4.5e-13 49.3 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ERG4_ERG24 PF01222.12 EDK40450.2 - 6.7e-142 473.0 12.3 7.6e-142 472.8 8.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 EDK40450.2 - 0.00017 21.0 1.5 0.00041 19.7 1.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) MFS_1 PF07690.11 EDK40451.2 - 1.4e-26 93.1 32.6 2.1e-26 92.4 22.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Aldolase_II PF00596.16 EDK40452.2 - 8.5e-44 149.3 0.1 1.1e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Peptidase_M20 PF01546.23 EDK40453.1 - 2.1e-26 92.6 0.1 3e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK40453.1 - 1.5e-07 31.1 0.4 3.8e-07 29.8 0.3 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 EDK40453.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Epimerase PF01370.16 EDK40454.2 - 5.5e-18 65.2 0.0 7.9e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EDK40454.2 - 3.5e-13 49.9 0.5 1.8e-12 47.6 0.3 1.9 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK40454.2 - 3.3e-10 39.3 0.2 1.3e-07 30.8 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 EDK40454.2 - 1.1e-09 37.4 0.0 1.4e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 EDK40454.2 - 6.4e-07 28.8 0.2 3.2e-06 26.5 0.1 2.2 2 1 0 2 2 2 1 NmrA-like family adh_short PF00106.20 EDK40454.2 - 0.013 15.3 0.0 0.054 13.4 0.0 1.9 1 1 0 1 1 1 0 short chain dehydrogenase KR PF08659.5 EDK40454.2 - 0.044 13.4 0.1 0.36 10.4 0.1 2.1 1 1 0 1 1 1 0 KR domain DapB_N PF01113.15 EDK40454.2 - 0.1 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Fungal_trans_2 PF11951.3 EDK40455.2 - 2.7e-72 243.5 0.5 3.8e-72 242.9 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40455.2 - 8.1e-06 25.6 15.3 8.1e-06 25.6 10.6 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.7 EDK40456.2 - 3.1e-32 110.5 1.4 5e-32 109.9 1.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK40456.2 - 6.1e-15 54.9 0.0 1e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.1 EDK40456.2 - 0.19 11.3 0.5 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-associated EamA PF00892.15 EDK40457.2 - 7.9e-10 38.8 7.1 7.9e-10 38.8 4.9 4.1 3 1 1 4 4 4 1 EamA-like transporter family EmrE PF13536.1 EDK40457.2 - 2.8e-06 27.5 6.7 2.8e-06 27.5 4.6 3.8 3 2 0 3 3 3 1 Multidrug resistance efflux transporter TPT PF03151.11 EDK40457.2 - 3.3e-05 23.5 23.5 0.00051 19.7 5.7 2.5 2 1 0 2 2 2 2 Triose-phosphate Transporter family Nuc_sug_transp PF04142.10 EDK40457.2 - 0.00073 18.7 0.8 0.0015 17.6 0.6 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter DUF914 PF06027.7 EDK40457.2 - 0.021 13.6 11.6 0.011 14.5 6.9 1.3 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) MFS_1 PF07690.11 EDK40458.2 - 8.3e-46 156.2 57.0 3.4e-44 150.9 39.5 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK40458.2 - 3.7e-10 38.9 15.0 3.7e-10 38.9 10.4 3.0 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40459.2 - 1.7e-27 96.1 19.2 1.7e-27 96.1 13.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily FMO-like PF00743.14 EDK40460.2 - 1.7e-21 76.0 4.0 4.9e-10 38.2 0.1 3.0 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 EDK40460.2 - 8e-15 55.4 0.5 1.2e-09 38.5 0.1 2.4 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK40460.2 - 1.4e-11 43.9 0.8 2.9e-07 29.7 0.1 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 EDK40460.2 - 4.3e-07 29.8 0.7 5.6e-06 26.2 0.5 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EDK40460.2 - 1.5e-05 24.8 0.2 5.4e-05 23.1 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EDK40460.2 - 9.1e-05 22.4 0.0 0.0018 18.1 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EDK40460.2 - 0.0049 15.8 1.2 0.012 14.4 0.7 1.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.12 EDK40460.2 - 0.018 14.1 0.1 1.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Thi4 family DUF905 PF06006.7 EDK40460.2 - 0.027 13.8 0.3 0.078 12.3 0.2 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) DUF2874 PF11396.3 EDK40460.2 - 0.11 12.5 2.0 3 7.8 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2874) TauD PF02668.11 EDK40461.2 - 1.3e-46 159.4 0.1 2e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Oxysterol_BP PF01237.13 EDK40462.2 - 2.3e-107 358.5 0.3 3.2e-107 358.1 0.2 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.1 EDK40462.2 - 2.1e-33 114.2 0.3 4.3e-33 113.2 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain zf-C3HC4_2 PF13923.1 EDK40463.2 - 2.1e-08 34.0 7.8 2.1e-08 34.0 5.4 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK40463.2 - 2.5e-08 33.6 6.2 2.5e-08 33.6 4.3 2.6 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 EDK40463.2 - 3.2e-07 29.9 5.7 9.9e-07 28.3 3.9 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK40463.2 - 8.3e-07 28.7 7.8 8.3e-07 28.7 5.4 3.0 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 EDK40463.2 - 8.4e-07 28.5 6.2 8.4e-07 28.5 4.3 3.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK40463.2 - 1.5e-05 24.5 4.5 1.5e-05 24.5 3.1 3.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK40463.2 - 5.7e-05 22.7 6.0 5.7e-05 22.7 4.2 3.2 2 1 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.3 EDK40463.2 - 0.00012 21.4 3.1 0.00012 21.4 2.1 2.5 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit bZIP_1 PF00170.16 EDK40463.2 - 0.068 13.1 0.6 0.83 9.6 0.0 2.4 2 0 0 2 2 2 0 bZIP transcription factor Sina PF03145.11 EDK40463.2 - 0.078 12.6 20.1 0.31 10.6 4.2 3.3 1 1 2 3 3 3 0 Seven in absentia protein family G_glu_transpept PF01019.16 EDK40464.2 - 6.3e-130 434.0 0.0 7.1e-130 433.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Sugar_tr PF00083.19 EDK40465.2 - 3.2e-08 32.5 2.9 5.1e-08 31.9 2.0 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter DUF456 PF04306.8 EDK40465.2 - 0.0026 17.7 2.4 0.0026 17.7 1.7 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF456) MFS_1 PF07690.11 EDK40465.2 - 0.017 13.8 12.1 0.0093 14.7 6.9 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily 7TMR-DISM_7TM PF07695.6 EDK40465.2 - 0.2 11.2 6.5 0.44 10.1 0.2 2.2 1 1 1 2 2 2 0 7TM diverse intracellular signalling NfeD PF01957.13 EDK40465.2 - 0.21 11.6 2.9 0.46 10.6 0.6 2.2 1 1 0 2 2 2 0 NfeD-like C-terminal, partner-binding YwiC PF14256.1 EDK40465.2 - 0.42 10.7 3.0 3 7.9 0.6 2.5 1 1 1 2 2 2 0 YwiC-like protein NVEALA PF14055.1 EDK40465.2 - 1.3 8.8 4.4 0.86 9.3 0.2 2.6 3 0 0 3 3 3 0 NVEALA protein MFS_1 PF07690.11 EDK40466.1 - 5.7e-14 51.5 2.6 6.2e-14 51.4 1.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.13 EDK40467.2 - 2.5e-18 65.8 0.4 5.3e-18 64.8 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MAGE PF01454.14 EDK40468.2 - 1e-20 73.9 0.0 1.4e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 MAGE family FAD_binding_1 PF00667.15 EDK40469.2 - 1.2e-63 214.4 0.0 1.8e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 EDK40469.2 - 3.4e-32 111.3 2.1 3.4e-32 111.3 1.5 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.16 EDK40469.2 - 4.9e-25 88.2 0.5 4e-23 82.0 0.0 3.2 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 EDK40469.2 - 0.00082 19.3 0.1 0.0036 17.2 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin domain Spore_IV_A PF09547.5 EDK40469.2 - 0.057 12.1 0.0 0.12 11.0 0.0 1.4 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Glyco_transf_18 PF15024.1 EDK40469.2 - 0.089 11.1 0.0 0.3 9.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase family 18 Ins_P5_2-kin PF06090.7 EDK40470.2 - 1.4e-84 283.7 5.7 1.7e-84 283.5 3.9 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase AIM24 PF01987.12 EDK40471.2 - 5.8e-08 32.4 0.1 1.2e-06 28.1 0.1 2.2 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 MKT1_C PF12246.3 EDK40472.2 - 2.5e-72 242.8 1.1 3.7e-72 242.2 0.8 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 EDK40472.2 - 1.7e-32 111.5 0.4 6.6e-32 109.7 0.2 2.1 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 EDK40472.2 - 4.2e-14 52.3 0.0 1.2e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 EDK40472.2 - 1.8e-13 50.6 0.1 1.7e-11 44.2 0.0 3.1 3 0 0 3 3 3 1 XPG N-terminal domain Xpo1 PF08389.7 EDK40473.2 - 0.0012 18.7 5.2 0.0012 18.7 3.6 4.5 3 2 0 3 3 3 1 Exportin 1-like protein Brix PF04427.13 EDK40474.1 - 8.4e-44 149.5 2.4 1.2e-43 148.9 1.6 1.2 1 0 0 1 1 1 1 Brix domain RNA_polI_A34 PF08208.6 EDK40474.1 - 0.2 11.3 0.0 0.2 11.3 0.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 MaoC_dehydrat_N PF13452.1 EDK40475.2 - 5e-06 26.3 0.0 0.12 12.1 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.14 EDK40475.2 - 0.00016 21.0 0.0 0.0003 20.1 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain Glyco_hydro_38 PF01074.17 EDK40477.2 - 8.5e-81 271.2 0.5 1.4e-80 270.5 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 EDK40477.2 - 1.3e-64 218.7 0.7 2.1e-64 218.0 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 EDK40477.2 - 4.8e-26 90.7 0.0 1.1e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Flocculin_t3 PF13928.1 EDK40478.1 - 3.5e-31 107.0 60.2 4.7e-16 58.6 16.1 3.1 3 0 0 3 3 3 2 Flocculin type 3 repeat HupH_C PF04809.8 EDK40478.1 - 0.039 13.7 0.4 0.09 12.5 0.3 1.6 1 1 0 1 1 1 0 HupH hydrogenase expression protein, C-terminal conserved region DUF2615 PF11027.3 EDK40478.1 - 4.3 7.3 7.7 17 5.4 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) zf-RING_5 PF14634.1 EDK40478.1 - 6.6 6.5 7.7 9.9 5.9 0.7 2.8 1 1 1 2 2 2 0 zinc-RING finger domain CCDC14 PF15254.1 EDK40478.1 - 6.8 4.9 12.1 5.3 5.2 6.7 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 14 LMP PF04778.7 EDK40479.2 - 0.0028 17.4 4.4 0.0028 17.4 3.0 2.0 2 0 0 2 2 2 1 LMP repeated region Baculo_PEP_C PF04513.7 EDK40479.2 - 0.0055 16.5 2.8 0.0079 16.0 0.1 2.3 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 EDK40479.2 - 0.024 14.2 0.4 0.091 12.3 0.2 2.0 1 0 0 1 1 1 0 IncA protein NPV_P10 PF05531.7 EDK40479.2 - 0.073 13.3 8.8 0.11 12.8 1.8 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein WEMBL PF05701.6 EDK40479.2 - 0.14 10.6 1.4 0.17 10.2 0.4 1.5 2 0 0 2 2 2 0 Weak chloroplast movement under blue light Enkurin PF13864.1 EDK40479.2 - 0.52 10.5 3.2 2.5 8.3 0.7 2.9 2 1 1 3 3 3 0 Calmodulin-binding Redoxin PF08534.5 EDK40480.1 - 1.6e-34 118.5 0.0 1.7e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EDK40480.1 - 3.1e-09 36.5 0.0 3.8e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family PIG-F PF06699.6 EDK40481.2 - 3e-54 183.8 8.5 3.6e-54 183.6 5.9 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Herpes_UL43 PF05072.8 EDK40481.2 - 0.12 11.0 8.0 0.26 9.9 1.8 2.1 2 0 0 2 2 2 0 Herpesvirus UL43 protein Gly-zipper_Omp PF13488.1 EDK40481.2 - 3.9 7.1 9.2 6.2 6.5 2.7 2.4 2 0 0 2 2 2 0 Glycine zipper PRA1 PF03208.14 EDK40481.2 - 5 6.4 7.7 17 4.7 2.9 2.3 2 0 0 2 2 2 0 PRA1 family protein CPSF_A PF03178.10 EDK40482.2 - 3.4e-93 312.2 0.7 3.8e-91 305.5 0.1 2.3 2 0 0 2 2 2 2 CPSF A subunit region Hira PF07569.6 EDK40482.2 - 0.11 11.6 0.6 0.87 8.7 0.0 2.7 4 0 0 4 4 4 0 TUP1-like enhancer of split Flocculin_t3 PF13928.1 EDK40483.2 - 2.3e-17 62.8 77.5 1.4e-12 47.4 15.2 7.9 6 3 1 7 7 7 3 Flocculin type 3 repeat Isochorismatase PF00857.15 EDK40484.2 - 6.2e-22 78.3 0.0 8.4e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family ADH_zinc_N PF00107.21 EDK40485.2 - 0.00043 19.8 0.3 0.0014 18.2 0.1 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.19 EDK40485.2 - 0.005 17.1 0.0 0.0096 16.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain ADH_N PF08240.7 EDK40485.2 - 0.024 14.4 0.2 0.066 12.9 0.1 1.7 1 1 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.13 EDK40485.2 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Thioredoxin PF00085.15 EDK40486.2 - 1.1e-14 53.9 0.0 1.4e-09 37.5 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.1 EDK40486.2 - 1.8e-05 24.7 0.8 0.0084 16.1 0.1 2.9 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.1 EDK40486.2 - 0.0001 22.4 0.4 0.0046 17.1 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.1 EDK40486.2 - 0.0056 16.1 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 F plasmid transfer operon protein ER_lumen_recept PF00810.13 EDK40487.1 - 4.2e-54 183.0 8.5 4.2e-54 183.0 5.9 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.9 EDK40487.1 - 0.52 9.9 10.2 5.4 6.6 0.2 4.3 2 1 2 4 4 4 0 PQ loop repeat Proteasome PF00227.21 EDK40488.2 - 1.5e-36 125.4 0.1 9.5e-36 122.8 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit zf-Tim10_DDP PF02953.10 EDK40489.2 - 7.8e-25 85.9 0.9 9.3e-25 85.7 0.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MFS_1 PF07690.11 EDK40490.2 - 5.1e-14 51.7 20.2 7.5e-14 51.1 14.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK40490.2 - 1.9 7.9 10.5 0.085 12.3 2.0 2.4 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 EDK40491.2 - 1.9e-19 69.5 15.0 2.7e-19 69.1 10.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK40491.2 - 0.052 13.0 5.4 0.017 14.6 1.4 1.9 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 DUF308 PF03729.8 EDK40491.2 - 1.2 9.1 8.6 1.2 9.2 3.6 2.7 1 1 2 3 3 3 0 Short repeat of unknown function (DUF308) MFS_1 PF07690.11 EDK40492.1 - 0.0011 17.8 0.3 0.0014 17.4 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK40493.2 - 1.9e-07 30.1 9.4 1.9e-07 30.1 6.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Imm9 PF15561.1 EDK40493.2 - 0.038 13.5 1.6 0.16 11.5 0.2 2.1 2 0 0 2 2 2 0 Immunity protein 9 MFS_1_like PF12832.2 EDK40493.2 - 0.5 10.1 6.6 2.5 7.9 0.1 2.7 2 0 0 2 2 2 0 MFS_1 like family DUF308 PF03729.8 EDK40493.2 - 8.2 6.5 9.4 0.51 10.3 2.1 2.4 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Ctr PF04145.10 EDK40494.1 - 2.3e-42 144.4 2.3 2.6e-42 144.2 1.6 1.0 1 0 0 1 1 1 1 Ctr copper transporter family ATP_synt_I PF03899.10 EDK40494.1 - 0.53 10.4 10.2 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 ATP synthase I chain DUF676 PF05057.9 EDK40495.2 - 4e-39 134.1 0.1 5.9e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EDK40495.2 - 0.00049 19.7 0.0 0.00086 18.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EDK40495.2 - 0.0051 16.4 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 EDK40495.2 - 0.0053 16.5 0.0 0.012 15.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK40495.2 - 0.013 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK40495.2 - 0.024 14.5 0.0 0.05 13.4 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family DLH PF01738.13 EDK40495.2 - 0.091 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF1890 PF09001.6 EDK40495.2 - 0.11 12.5 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1890) Melibiase PF02065.13 EDK40496.2 - 3.3e-38 131.4 0.0 1.2e-19 70.2 0.0 2.1 1 1 1 2 2 2 2 Melibiase Epimerase PF01370.16 EDK40497.2 - 1.7e-19 70.1 0.0 2.3e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK40497.2 - 1.2e-09 37.2 0.0 1.8e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK40497.2 - 4.9e-07 29.9 0.1 1.1e-06 28.8 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK40497.2 - 0.00034 19.6 0.2 0.03 13.2 0.1 2.4 1 1 1 2 2 2 1 Male sterility protein NmrA PF05368.8 EDK40497.2 - 0.00095 18.4 0.1 0.0034 16.6 0.0 1.9 2 1 0 2 2 2 1 NmrA-like family Gp_dh_C PF02800.15 EDK40498.2 - 4.8e-69 230.8 0.0 6.8e-69 230.3 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 EDK40498.2 - 6.3e-60 201.5 0.1 9.8e-60 200.8 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DUF2436 PF10365.4 EDK40498.2 - 0.0054 16.3 0.3 0.0095 15.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2436) DapB_N PF01113.15 EDK40498.2 - 0.017 15.0 0.1 0.062 13.2 0.1 2.1 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 EDK40498.2 - 0.054 12.6 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PABP PF00658.13 EDK40498.2 - 0.16 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain Peptidase_S15 PF02129.13 EDK40499.2 - 2.5e-53 181.2 0.9 4.2e-53 180.5 0.6 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 EDK40499.2 - 3.4e-26 92.4 0.0 9.1e-26 91.1 0.0 1.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_6 PF12697.2 EDK40499.2 - 6e-07 29.5 0.0 1.4e-06 28.3 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK40499.2 - 6.1e-06 26.0 0.0 2.2e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Sugar_tr PF00083.19 EDK40500.2 - 1.4e-20 73.3 24.3 2.6e-20 72.4 16.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40500.2 - 1.6e-20 73.1 29.2 4.4e-19 68.4 10.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily EXS PF03124.9 EDK40501.2 - 3.7e-86 289.2 23.4 5.4e-86 288.7 16.2 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.14 EDK40501.2 - 1.9e-23 83.6 4.7 3.5e-23 82.7 3.3 1.3 1 0 0 1 1 1 1 SPX domain UPF0075 PF03702.9 EDK40502.2 - 9.6e-86 287.9 0.0 1.2e-85 287.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0075) MFS_1 PF07690.11 EDK40503.2 - 1.3e-13 50.4 32.5 1.3e-13 50.4 22.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.11 EDK40503.2 - 1.1e-08 34.7 7.0 1.1e-08 34.7 4.8 2.9 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 PrgI PF12666.2 EDK40503.2 - 0.21 11.7 0.1 0.21 11.7 0.1 4.3 3 2 1 4 4 4 0 PrgI family protein Fungal_trans PF04082.13 EDK40504.2 - 7.2e-31 106.9 1.0 1e-30 106.4 0.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40504.2 - 1.4e-08 34.4 13.4 1.4e-08 34.4 9.3 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.9 EDK40505.2 - 4.9e-24 85.3 0.0 1.4e-23 83.8 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK40505.2 - 5.8e-11 42.6 0.0 7.4e-10 39.1 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK40505.2 - 8.7e-06 25.9 0.1 0.0051 16.8 0.1 3.3 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 EDK40505.2 - 0.027 14.4 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain LRR_4 PF12799.2 EDK40507.2 - 3.4e-07 29.7 36.3 0.00031 20.3 1.8 10.1 6 3 4 10 10 10 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK40507.2 - 7.3e-06 25.3 26.9 1.1 9.5 1.3 10.6 7 5 3 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.1 EDK40507.2 - 1.5e-05 24.6 0.9 1.5e-05 24.6 0.6 7.7 6 4 4 10 10 10 3 Leucine rich repeat FNIP PF05725.7 EDK40507.2 - 0.00016 21.5 20.6 0.13 12.2 0.1 7.2 8 1 1 9 9 9 3 FNIP Repeat LRR_7 PF13504.1 EDK40507.2 - 0.00059 19.6 26.5 0.26 11.6 0.1 12.3 15 0 0 15 15 15 1 Leucine rich repeat LRR_5 PF13306.1 EDK40507.2 - 0.007 16.0 4.5 1.5 8.5 0.0 4.4 3 1 1 4 4 4 1 Leucine rich repeats (6 copies) DUF917 PF06032.7 EDK40509.2 - 4.8e-95 318.0 0.0 7.9e-95 317.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 EDK40509.2 - 5.8e-52 176.5 5.5 1.4e-50 172.0 1.1 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EDK40509.2 - 6e-36 123.5 1.3 2.2e-32 111.9 0.0 3.6 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.1 EDK40509.2 - 0.00041 18.8 0.6 0.062 11.6 0.0 2.2 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.15 EDK40509.2 - 0.0043 16.3 0.5 0.033 13.4 0.2 2.8 1 1 1 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Transp_cyt_pur PF02133.10 EDK40510.1 - 1.6e-71 241.1 34.8 1.9e-71 240.9 24.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin F-box PF00646.28 EDK40511.2 - 0.0023 17.5 1.1 0.018 14.7 0.2 2.9 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.2 EDK40511.2 - 0.0043 16.6 14.2 0.64 9.6 0.0 6.5 6 2 0 6 6 6 2 Leucine Rich repeats (2 copies) Chloroplast_duf PF14476.1 EDK40511.2 - 0.21 10.3 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 Petal formation-expressed DUF3452 PF11934.3 EDK40512.2 - 0.066 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) Polyketide_cyc2 PF10604.4 EDK40513.2 - 2.4e-10 40.7 0.0 2.7e-10 40.5 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sugar_tr PF00083.19 EDK40514.2 - 2.4e-59 201.1 12.9 2.6e-59 200.9 8.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40514.2 - 2.4e-10 39.6 24.4 2e-06 26.8 3.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 EDK40516.1 - 0.00035 19.3 8.6 0.00035 19.3 6.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Acyl_transf_3 PF01757.17 EDK40516.1 - 0.021 13.6 5.1 0.026 13.3 3.6 1.0 1 0 0 1 1 1 0 Acyltransferase family DUF606 PF04657.8 EDK40516.1 - 0.032 14.3 5.9 0.12 12.4 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function, DUF606 DUF1385 PF07136.6 EDK40516.1 - 0.043 12.8 0.7 0.13 11.3 0.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1385) EcsB PF05975.7 EDK40516.1 - 0.069 11.6 2.5 0.09 11.2 1.7 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB 7TMR-DISM_7TM PF07695.6 EDK40516.1 - 0.58 9.7 12.2 1.6 8.3 8.7 1.5 1 1 0 1 1 1 0 7TM diverse intracellular signalling MgtC PF02308.11 EDK40516.1 - 0.8 9.5 4.7 2 8.2 1.8 2.3 1 1 2 3 3 3 0 MgtC family Oxidored_q2 PF00420.19 EDK40516.1 - 1.7 8.3 6.9 3.1 7.4 4.8 1.4 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Peptidase_U4 PF03419.8 EDK40516.1 - 2.8 6.9 7.3 4.5 6.2 5.1 1.4 1 1 0 1 1 1 0 Sporulation factor SpoIIGA ABC2_membrane_4 PF12730.2 EDK40516.1 - 2.9 7.0 14.6 0.45 9.6 6.1 1.9 1 1 2 3 3 3 0 ABC-2 family transporter protein MFS_1 PF07690.11 EDK40517.1 - 2.3e-23 82.4 15.2 2.8e-23 82.2 10.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DVL PF08137.7 EDK40517.1 - 0.27 10.7 1.2 0.65 9.4 0.8 1.6 1 0 0 1 1 1 0 DVL family MFS_1 PF07690.11 EDK40518.1 - 1.4e-33 116.0 30.3 1.4e-33 116.0 21.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DAO PF01266.19 EDK40519.1 - 1.9e-20 73.0 0.0 2.3e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 EDK40519.1 - 5.4e-05 23.1 0.0 9.8e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 EDK40519.1 - 0.014 14.2 0.0 0.021 13.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 EDK40519.1 - 0.015 15.4 0.0 0.057 13.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK40519.1 - 0.015 15.0 0.0 0.033 13.9 0.0 1.6 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 EDK40519.1 - 0.041 14.2 0.0 0.12 12.8 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EDK40519.1 - 0.053 12.5 0.0 0.076 12.0 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.16 EDK40519.1 - 0.081 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 ThiF family Pyr_redox_2 PF07992.9 EDK40519.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EDK40519.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 EDK40520.1 - 1.9e-08 33.5 0.0 2.3e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA_C PF08546.6 EDK40522.1 - 1.5e-28 99.2 0.0 2.2e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EDK40522.1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Aminotran_1_2 PF00155.16 EDK40523.2 - 1.9e-15 56.6 0.0 2.4e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EDK40523.2 - 0.0013 17.9 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 EDK40523.2 - 0.062 12.3 0.1 2.1 7.2 0.0 2.6 2 1 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Asp_Glu_race PF01177.17 EDK40524.1 - 4e-05 23.6 0.2 0.00027 20.8 0.1 1.9 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Fungal_trans PF04082.13 EDK40525.2 - 2.2e-22 79.2 0.7 4.5e-22 78.1 0.5 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40525.2 - 1.3e-09 37.8 8.7 2.3e-09 36.9 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_31 PF13847.1 EDK40526.2 - 5.3e-30 104.0 0.0 7.3e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK40526.2 - 4.3e-27 94.4 0.0 7.9e-27 93.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK40526.2 - 1.3e-21 76.8 0.0 1.9e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 EDK40526.2 - 1.9e-16 60.2 0.0 3.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40526.2 - 2e-15 57.3 0.0 4.5e-15 56.2 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK40526.2 - 3.9e-15 56.1 0.0 7.1e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK40526.2 - 4.8e-13 49.1 0.0 7.4e-13 48.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK40526.2 - 2e-09 37.5 0.0 3.4e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK40526.2 - 8.7e-09 34.9 0.0 1.3e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 EDK40526.2 - 4.1e-06 26.4 0.0 5.5e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 EDK40526.2 - 5.1e-06 25.6 0.0 9.1e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MetW PF07021.7 EDK40526.2 - 6.5e-06 25.6 0.0 9.7e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_PK PF05891.7 EDK40526.2 - 1.3e-05 24.6 0.0 2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PrmA PF06325.8 EDK40526.2 - 5.6e-05 22.4 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.14 EDK40526.2 - 0.00021 21.3 0.0 0.00059 19.8 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 EDK40526.2 - 0.00025 20.7 0.1 0.0037 16.9 0.0 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.11 EDK40526.2 - 0.00032 19.1 0.0 0.00047 18.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_9 PF08003.6 EDK40526.2 - 0.00034 19.4 0.0 0.00056 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.1 EDK40526.2 - 0.0025 17.5 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 EDK40526.2 - 0.0032 16.8 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) DREV PF05219.7 EDK40526.2 - 0.0054 15.6 0.0 0.0082 15.0 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.15 EDK40526.2 - 0.008 15.2 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TehB PF03848.9 EDK40526.2 - 0.0087 15.2 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB UPF0020 PF01170.13 EDK40526.2 - 0.034 13.7 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Sulfatase PF00884.18 EDK40527.2 - 5e-40 137.6 0.0 6.5e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 EDK40527.2 - 7.2e-09 35.4 0.2 0.00022 20.6 0.0 2.5 2 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.12 EDK40527.2 - 0.043 12.2 0.0 0.063 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_hydro_81 PF03639.8 EDK40528.2 - 9.3e-195 648.6 3.9 1.1e-194 648.4 2.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 Arm PF00514.18 EDK40530.2 - 5.7e-84 273.4 14.1 2.9e-13 49.0 0.0 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 EDK40530.2 - 3.2e-23 81.7 0.1 1.2e-05 25.5 0.0 5.9 2 2 3 5 5 5 5 HEAT repeats IBB PF01749.15 EDK40530.2 - 5.2e-23 81.0 6.2 1.1e-22 80.0 4.3 1.6 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.1 EDK40530.2 - 8.7e-21 73.8 1.2 3.1e-06 27.5 0.0 4.9 3 1 2 5 5 5 3 HEAT-like repeat HEAT PF02985.17 EDK40530.2 - 1.3e-14 52.9 0.1 0.0071 16.3 0.0 6.7 7 0 0 7 7 7 3 HEAT repeat Arm_2 PF04826.8 EDK40530.2 - 1.3e-06 27.6 0.1 0.082 12.0 0.0 4.5 1 1 3 4 4 4 1 Armadillo-like Adaptin_N PF01602.15 EDK40530.2 - 2.3e-06 26.2 0.0 0.0059 14.9 0.0 2.2 1 1 1 2 2 2 2 Adaptin N terminal region RICTOR_V PF14668.1 EDK40530.2 - 5.4e-05 23.0 3.0 2.1 8.3 0.0 5.6 5 2 2 7 7 7 2 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.3 EDK40530.2 - 7.3e-05 22.6 0.0 0.49 10.3 0.0 4.3 3 1 2 5 5 5 1 V-ATPase subunit H Proteasom_PSMB PF10508.4 EDK40530.2 - 8.2e-05 21.0 0.1 0.021 13.1 0.0 3.1 2 1 1 3 3 3 2 Proteasome non-ATPase 26S subunit DUF2505 PF10698.4 EDK40530.2 - 0.075 12.5 0.0 1.7 8.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2505) Usp PF00582.21 EDK40532.2 - 1.1e-09 38.6 0.0 1.8e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family DNA_photolyase PF00875.13 EDK40532.2 - 0.095 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 DNA photolyase Far-17a_AIG1 PF04750.9 EDK40533.2 - 1.5e-24 86.3 12.1 1.6e-24 86.2 8.4 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein TraL PF07178.6 EDK40533.2 - 6.1 6.9 8.2 0.63 10.0 0.3 3.0 2 1 1 3 3 3 0 TraL protein Far-17a_AIG1 PF04750.9 EDK40534.2 - 4.6e-15 55.3 12.1 5.6e-15 55.0 8.4 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Peptidase_M14 PF00246.19 EDK40535.2 - 1e-63 215.5 0.1 1.5e-63 215.0 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.11 EDK40535.2 - 0.0033 17.0 0.1 0.009 15.6 0.1 1.8 1 0 0 1 1 1 1 Carboxypeptidase activation peptide WND PF07861.6 EDK40535.2 - 0.021 13.8 0.1 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 WisP family N-Terminal Region Tyr_Deacylase PF02580.11 EDK40536.2 - 2.4e-47 160.5 0.0 3.2e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase eIF2_C PF09173.6 EDK40536.2 - 0.071 13.1 0.5 0.11 12.5 0.4 1.3 1 0 0 1 1 1 0 Initiation factor eIF2 gamma, C terminal Aa_trans PF01490.13 EDK40537.1 - 1.2e-31 109.6 31.9 1.5e-31 109.3 22.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YqzM PF14141.1 EDK40537.1 - 0.19 11.5 0.1 0.19 11.5 0.1 2.4 3 0 0 3 3 3 0 YqzM-like protein F-box-like PF12937.2 EDK40539.2 - 0.0017 17.9 0.1 0.0064 16.1 0.0 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 EDK40539.2 - 0.0043 16.6 0.2 0.013 15.1 0.2 1.9 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 EDK40539.2 - 0.013 15.2 0.3 0.032 13.9 0.2 1.8 1 1 0 1 1 1 0 F-box-like domain FTH PF01827.22 EDK40539.2 - 0.34 10.5 2.9 1.4 8.4 0.1 3.0 3 1 0 3 3 3 0 FTH domain Pga1 PF10333.4 EDK40540.2 - 1.6e-08 34.4 0.3 8.1e-08 32.1 0.2 1.8 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Endosulfine PF04667.12 EDK40541.2 - 3.7e-30 103.7 1.1 5e-30 103.3 0.7 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region S-antigen PF05756.6 EDK40541.2 - 0.03 14.2 0.5 0.049 13.6 0.2 1.5 1 1 0 1 1 1 0 S-antigen protein Autophagy_act_C PF03987.10 EDK40542.2 - 5.7e-16 58.4 0.6 1e-15 57.6 0.4 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain INSIG PF07281.7 EDK40544.2 - 3.3e-22 78.7 1.6 4.8e-22 78.2 1.1 1.3 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) Colicin_V PF02674.11 EDK40544.2 - 0.49 10.2 8.0 1.9 8.3 3.3 2.3 2 0 0 2 2 2 0 Colicin V production protein WLM PF08325.5 EDK40545.2 - 6.5e-49 166.3 0.0 9e-49 165.8 0.0 1.1 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.12 EDK40545.2 - 0.063 13.0 0.1 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF45 TMP-TENI PF02581.12 EDK40546.2 - 1.6e-53 180.5 0.8 2.4e-53 179.9 0.5 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI HK PF02110.10 EDK40546.2 - 4.3e-40 137.4 0.1 8.9e-40 136.4 0.1 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family Flu_M1_C PF08289.6 EDK40546.2 - 0.087 12.8 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain RNase_P_Rpp14 PF01900.14 EDK40547.2 - 8.3e-39 131.8 0.0 1.1e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family TPR_19 PF14559.1 EDK40548.2 - 6.2e-23 80.9 3.3 7.1e-09 35.8 0.2 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 EDK40548.2 - 2.9e-21 75.2 13.0 1.6e-07 31.1 0.1 6.7 5 1 1 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 EDK40548.2 - 7.6e-20 71.0 2.7 7.3e-08 32.8 0.1 6.0 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 EDK40548.2 - 2.4e-19 68.7 9.3 1.2e-06 28.0 0.1 7.6 6 1 1 8 8 8 5 TPR repeat TPR_2 PF07719.12 EDK40548.2 - 5.7e-17 60.2 15.7 0.0045 16.8 0.0 9.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.1 EDK40548.2 - 3e-16 58.4 2.9 0.00013 22.2 0.0 8.8 7 3 3 10 10 9 4 Tetratricopeptide repeat TPR_1 PF00515.23 EDK40548.2 - 3.1e-15 55.0 8.3 0.00098 18.6 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat Apc3 PF12895.2 EDK40548.2 - 2.4e-14 53.1 7.3 2.7e-08 33.8 0.0 5.0 6 0 0 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 EDK40548.2 - 8.2e-12 44.7 7.9 0.67 10.5 0.0 7.7 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK40548.2 - 9.7e-11 40.6 23.2 0.0013 18.3 0.0 8.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 EDK40548.2 - 1.1e-08 34.6 5.5 0.047 13.9 0.1 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.1 EDK40548.2 - 1.5e-08 34.3 2.5 1.1 9.2 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 EDK40548.2 - 1.9e-08 33.4 0.7 0.23 11.3 0.0 5.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 EDK40548.2 - 5.5e-08 32.8 3.0 0.00041 20.4 0.2 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 EDK40548.2 - 1.6e-06 27.3 6.4 0.0042 16.1 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 EDK40548.2 - 5e-06 26.2 1.6 0.17 11.7 0.0 5.2 5 1 1 6 6 5 1 Tetratricopeptide repeat RPN7 PF10602.4 EDK40548.2 - 3.5e-05 23.2 2.7 0.46 9.8 0.1 4.7 3 1 0 3 3 3 1 26S proteasome subunit RPN7 NARP1 PF12569.3 EDK40548.2 - 0.0017 17.1 9.7 0.63 8.7 0.0 4.0 3 1 1 4 4 4 3 NMDA receptor-regulated protein 1 TPR_5 PF12688.2 EDK40548.2 - 0.021 14.8 2.5 0.08 12.9 0.0 3.2 5 0 0 5 5 3 0 Tetratrico peptide repeat Alkyl_sulf_dimr PF14863.1 EDK40548.2 - 0.04 14.1 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_4 PF07721.9 EDK40548.2 - 0.052 13.9 0.8 0.052 13.9 0.6 2.9 3 0 0 3 3 1 0 Tetratricopeptide repeat UDP-g_GGTase PF06427.6 EDK40549.2 - 1.8e-23 82.9 0.6 3.2e-23 82.1 0.4 1.4 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 EDK40549.2 - 1.2e-08 34.5 0.0 3.1e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 MTHFR PF02219.12 EDK40550.2 - 5.6e-06 25.6 0.3 8.4e-06 25.0 0.2 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase TLD PF07534.11 EDK40552.2 - 6.6e-28 97.4 0.5 9.4e-25 87.2 0.2 2.1 1 1 1 2 2 2 2 TLD Asp_Glu_race PF01177.17 EDK40553.2 - 2.6e-28 99.4 0.0 2.9e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Rad9 PF04139.8 EDK40554.2 - 4.2e-13 49.0 1.9 1.3e-12 47.3 1.3 1.8 1 1 0 1 1 1 1 Rad9 MPC PF03650.8 EDK40555.1 - 6.6e-36 122.8 0.0 7.3e-36 122.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Zn_clus PF00172.13 EDK40556.2 - 1.6e-07 31.1 14.9 3.2e-07 30.1 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF972 PF06156.8 EDK40556.2 - 0.082 13.2 0.1 0.082 13.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF972) CCDC32 PF14989.1 EDK40557.1 - 0.074 12.8 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing 32 RAP1 PF07218.6 EDK40557.1 - 0.98 7.4 3.9 1.3 7.0 2.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Cytochrom_B559 PF00283.14 EDK40558.2 - 0.19 11.0 3.2 0.57 9.5 2.2 1.8 1 0 0 1 1 1 0 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits DJ-1_PfpI PF01965.19 EDK40559.2 - 1.6e-23 82.7 0.1 3.2e-23 81.8 0.1 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family DJ-1_PfpI_N PF13587.1 EDK40559.2 - 3.1e-05 23.4 0.0 6.1e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of DJ-1_PfpI family Acyltransferase PF01553.16 EDK40560.1 - 2.1e-31 108.1 0.0 3e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Adaptin_N PF01602.15 EDK40561.2 - 8e-91 304.9 14.8 1.9e-90 303.6 9.7 1.9 2 1 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.2 EDK40561.2 - 1.9e-12 47.4 1.2 1.9e-12 47.4 0.8 2.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 L27 PF02828.11 EDK40561.2 - 0.019 14.6 0.2 0.056 13.1 0.2 1.9 1 0 0 1 1 1 0 L27 domain CENP-U PF13097.1 EDK40562.2 - 5.4e-15 55.7 1.3 5.4e-08 32.9 0.0 2.4 1 1 1 2 2 2 2 CENP-A nucleosome associated complex (NAC) subunit KxDL PF10241.4 EDK40562.2 - 7.8e-05 22.5 1.9 0.00014 21.6 1.3 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein STAT_alpha PF01017.15 EDK40562.2 - 0.0058 16.3 0.5 0.0099 15.6 0.3 1.4 2 0 0 2 2 2 1 STAT protein, all-alpha domain Ly49 PF08391.5 EDK40562.2 - 0.023 14.7 2.0 0.039 14.0 1.4 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Metallopep PF12044.3 EDK40563.2 - 6.4e-151 502.5 0.0 7.6e-151 502.3 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 EDK40563.2 - 2.8e-07 30.4 0.0 1.2e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Jacalin-like lectin domain Reprolysin_2 PF13574.1 EDK40563.2 - 0.0053 16.8 0.2 0.01 15.8 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 EDK40563.2 - 0.0054 17.2 0.2 0.014 15.9 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 EDK40563.2 - 0.0099 15.8 0.5 0.019 14.9 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M66 PF10462.4 EDK40563.2 - 0.068 12.0 0.0 0.18 10.6 0.1 1.6 2 0 0 2 2 2 0 Peptidase M66 Reprolysin_4 PF13583.1 EDK40563.2 - 0.092 12.2 0.1 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Tyr-DNA_phospho PF06087.7 EDK40564.2 - 2.3e-138 461.5 0.5 2.8e-138 461.2 0.4 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase DUF1906 PF08924.6 EDK40564.2 - 0.011 15.6 0.1 0.025 14.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1906) SMC_N PF02463.14 EDK40565.2 - 7.8e-54 182.2 53.2 1.1e-52 178.4 36.9 3.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 EDK40565.2 - 5.2e-29 100.6 0.1 3.8e-28 97.8 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 EDK40565.2 - 1.3e-15 58.2 9.9 1.3e-15 58.2 6.9 7.3 2 2 2 4 4 1 1 AAA domain AAA_21 PF13304.1 EDK40565.2 - 4.5e-15 56.3 10.8 1.5e-08 34.9 0.1 3.6 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.1 EDK40565.2 - 0.0013 18.2 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 EDK40565.2 - 0.0055 16.1 4.4 0.1 12.0 0.0 3.5 3 0 0 3 3 3 1 FtsK/SpoIIIE family IncA PF04156.9 EDK40565.2 - 0.0073 15.9 13.6 0.0073 15.9 9.4 7.3 2 2 3 6 6 6 3 IncA protein AAA_13 PF13166.1 EDK40565.2 - 0.012 14.1 111.0 0.018 13.5 22.9 6.5 3 2 5 8 8 8 0 AAA domain MtrB PF05440.7 EDK40565.2 - 0.032 14.2 5.8 5.3 7.1 0.1 4.3 3 1 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B Reo_sigmaC PF04582.7 EDK40565.2 - 0.095 11.8 58.8 0.16 11.1 1.4 6.9 2 2 6 8 8 8 0 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 EDK40565.2 - 4.7 4.7 125.9 0.0052 14.5 21.4 4.5 2 2 2 4 4 4 0 Myosin tail DUF3584 PF12128.3 EDK40565.2 - 9.6 3.3 115.8 0.027 11.8 27.1 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF3584) EF-hand_1 PF00036.27 EDK40567.1 - 1.6e-28 95.7 3.9 5.2e-09 34.7 0.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 EDK40567.1 - 2.3e-26 91.1 3.3 2.3e-11 43.1 0.2 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 EDK40567.1 - 3.5e-24 84.6 1.5 1.7e-16 60.1 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 EDK40567.1 - 2.1e-22 77.3 3.9 1.1e-08 34.0 0.0 3.4 3 1 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 EDK40567.1 - 1.2e-17 62.1 2.6 2.8e-08 32.9 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_9 PF14658.1 EDK40567.1 - 5.1e-09 35.9 0.1 0.00028 20.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 EDK40567.1 - 4.9e-07 29.4 1.7 0.0036 17.0 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 EDK40567.1 - 7.4e-07 29.1 0.0 0.00014 21.8 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 EDK40567.1 - 1e-06 28.2 0.0 0.021 14.4 0.0 3.0 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) TerB PF05099.8 EDK40567.1 - 6.6e-05 22.6 0.5 0.0011 18.7 0.1 2.0 1 1 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_10 PF14788.1 EDK40567.1 - 0.0021 17.6 0.5 0.0065 16.1 0.0 2.0 2 1 0 2 2 2 1 EF hand Dockerin_1 PF00404.13 EDK40567.1 - 0.04 13.6 13.1 3 7.6 0.1 3.5 3 0 0 3 3 3 0 Dockerin type I repeat Poly_export PF02563.11 EDK40567.1 - 0.066 12.9 0.0 0.14 11.9 0.0 1.6 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein VCBS PF13517.1 EDK40567.1 - 0.11 12.9 2.5 0.66 10.3 1.7 2.2 1 1 1 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF533 PF04391.7 EDK40567.1 - 0.15 11.3 1.8 1.7 7.9 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF533) PB1 PF00564.19 EDK40567.1 - 0.2 11.3 0.8 23 4.7 0.1 2.7 2 1 1 3 3 3 0 PB1 domain DUF1296 PF06972.6 EDK40567.1 - 0.31 11.0 2.1 2.6 8.0 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1296) IMS PF00817.15 EDK40568.2 - 1e-35 122.7 0.0 1e-34 119.4 0.0 2.5 3 0 0 3 3 3 1 impB/mucB/samB family IMS_C PF11799.3 EDK40568.2 - 3.5e-13 49.6 0.0 1.1e-12 48.0 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.21 EDK40568.2 - 6.3e-06 26.2 0.1 1.6e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.3 EDK40568.2 - 6.4e-05 22.7 0.0 0.0016 18.3 0.0 3.0 3 0 0 3 3 3 1 IMS family HHH motif DUF4414 PF14377.1 EDK40568.2 - 0.033 14.0 11.4 0.44 10.4 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4414) PTCB-BRCT PF12738.2 EDK40568.2 - 0.054 13.3 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 twin BRCT domain Hist_deacetyl PF00850.14 EDK40569.2 - 2.1e-72 244.0 0.0 2.6e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glyco_trans_1_4 PF13692.1 EDK40570.2 - 6.4e-18 65.1 0.0 1.2e-17 64.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 EDK40570.2 - 7.2e-16 58.0 0.0 1e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 EDK40570.2 - 0.0012 19.0 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 XFP_C PF09363.5 EDK40570.2 - 0.023 14.1 0.1 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 XFP C-terminal domain XPA_C PF05181.7 EDK40571.2 - 8.8e-25 86.0 0.9 1.7e-24 85.1 0.1 2.0 2 0 0 2 2 2 1 XPA protein C-terminus XPA_N PF01286.13 EDK40571.2 - 0.00059 19.4 0.1 0.00059 19.4 0.1 2.1 3 0 0 3 3 3 1 XPA protein N-terminal FYVE_2 PF02318.11 EDK40571.2 - 3.4 7.6 15.5 0.36 10.7 0.9 3.4 3 0 0 3 3 3 0 FYVE-type zinc finger HSP90 PF00183.13 EDK40572.1 - 3e-253 841.0 35.1 3.6e-253 840.7 24.4 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 EDK40572.1 - 3.8e-11 42.6 0.0 7.1e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EDK40572.1 - 1.7e-10 40.7 0.0 1.7e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2435 PF10363.4 EDK40573.2 - 3.9e-33 113.2 0.3 1.9e-32 110.9 0.2 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2435) HEAT_2 PF13646.1 EDK40573.2 - 0.0013 18.9 0.1 0.52 10.6 0.0 3.0 2 0 0 2 2 2 2 HEAT repeats DUF2411 PF10304.4 EDK40573.2 - 0.0013 18.2 0.0 0.0043 16.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) Ank_2 PF12796.2 EDK40574.2 - 2.9e-19 69.2 0.2 7e-17 61.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 EDK40574.2 - 9.1e-18 63.8 0.2 1.2e-09 38.1 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 EDK40574.2 - 2.9e-17 61.5 0.2 9.2e-10 37.8 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 EDK40574.2 - 1.3e-15 57.4 0.0 1.5e-11 44.4 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK40574.2 - 3.1e-15 54.7 0.6 1.3e-07 31.1 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat eIF-5_eIF-2B PF01873.12 EDK40575.2 - 7.9e-45 151.5 0.1 1.2e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.10 EDK40575.2 - 0.03 13.9 0.0 0.099 12.3 0.0 1.9 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Pkinase PF00069.20 EDK40577.2 - 4.6e-38 130.8 0.0 2.9e-26 92.1 0.0 1.9 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40577.2 - 3e-15 55.9 0.0 2.4e-12 46.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 EDK40577.2 - 0.0095 14.9 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK40577.2 - 0.14 11.8 0.0 0.16 11.6 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Rhomboid PF01694.17 EDK40578.2 - 3e-12 46.7 6.6 3e-12 46.7 4.6 1.6 1 1 1 2 2 2 1 Rhomboid family Inp1 PF12634.2 EDK40579.2 - 6.8e-34 116.6 0.3 6.8e-34 116.6 0.2 2.9 2 1 0 2 2 2 1 Inheritance of peroxisomes protein 1 Porin_3 PF01459.17 EDK40580.2 - 2.1e-84 283.0 0.4 2.5e-84 282.8 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin PFK PF00365.15 EDK40581.2 - 1.4e-165 549.2 6.4 1.2e-122 408.3 2.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase Glyoxalase_2 PF12681.2 EDK40581.2 - 4.6e-05 23.9 0.0 0.00012 22.6 0.0 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 EDK40581.2 - 0.00099 19.0 0.0 0.0051 16.7 0.0 2.1 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily UVR PF02151.14 EDK40581.2 - 0.12 11.8 1.0 0.32 10.5 0.7 1.7 1 0 0 1 1 1 0 UvrB/uvrC motif TBCC PF07986.7 EDK40582.1 - 3.5e-13 48.9 1.0 6.6e-13 48.1 0.7 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TPP_enzyme_N PF02776.13 EDK40583.2 - 1.9e-20 73.0 0.0 3.2e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 EDK40583.2 - 3.1e-16 59.3 0.0 7e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 EDK40583.2 - 1.7e-05 24.5 0.0 3.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DAO PF01266.19 EDK40584.2 - 2.3e-15 56.3 0.0 3.6e-15 55.7 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Crl PF07417.7 EDK40584.2 - 0.062 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Crl Fungal_trans_2 PF11951.3 EDK40585.2 - 6.9e-46 156.5 0.0 8.3e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ran-binding PF05508.6 EDK40585.2 - 0.015 14.2 0.9 0.022 13.6 0.6 1.1 1 0 0 1 1 1 0 RanGTP-binding protein STAS PF01740.16 EDK40585.2 - 0.1 12.0 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 STAS domain DUF2443 PF10398.4 EDK40585.2 - 0.18 11.6 1.2 0.5 10.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) AA_permease PF00324.16 EDK40586.2 - 8.5e-89 298.0 50.3 1e-88 297.8 34.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40586.2 - 9e-23 80.4 52.6 1.1e-22 80.1 36.5 1.1 1 0 0 1 1 1 1 Amino acid permease Peptidase_M19 PF01244.16 EDK40587.2 - 6.8e-107 357.0 0.0 8.1e-107 356.8 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.9 EDK40587.2 - 0.004 16.7 0.0 0.0071 15.9 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase AMP-binding PF00501.23 EDK40588.2 - 2.6e-61 207.2 0.0 8e-60 202.3 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme TIP49 PF06068.8 EDK40589.1 - 2.8e-165 549.9 3.7 3.2e-165 549.6 2.6 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 EDK40589.1 - 1.2e-08 35.1 2.1 1.4e-05 25.2 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 EDK40589.1 - 3.8e-05 22.8 3.8 0.014 14.4 0.1 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 EDK40589.1 - 0.00011 22.3 0.1 0.11 12.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 EDK40589.1 - 0.00043 20.3 0.0 0.034 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain DnaB_C PF03796.10 EDK40589.1 - 0.0034 16.3 0.1 0.0059 15.5 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.16 EDK40589.1 - 0.004 16.3 0.8 0.077 12.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 EDK40589.1 - 0.01 15.5 0.1 1.4 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 EDK40589.1 - 0.021 14.5 0.2 0.043 13.5 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_25 PF13481.1 EDK40589.1 - 0.04 13.3 0.3 0.098 12.0 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EDK40589.1 - 0.044 13.7 0.1 0.34 10.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 EDK40589.1 - 0.12 13.2 0.0 0.38 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATP-synt_C PF00137.16 EDK40590.2 - 1.1e-26 92.5 28.3 7.7e-16 57.7 4.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Polysacc_synt_3 PF13440.1 EDK40590.2 - 0.02 14.3 0.6 0.02 14.3 0.4 2.3 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein Mis14 PF08641.7 EDK40591.2 - 6.9e-18 65.0 2.2 2e-17 63.5 0.7 2.0 1 1 1 2 2 2 1 Kinetochore protein Mis14 like SlyX PF04102.7 EDK40591.2 - 0.053 13.9 0.3 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 SlyX RasGAP_C PF03836.10 EDK40592.2 - 7.6e-45 152.0 8.7 2.5e-44 150.4 6.0 2.0 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.14 EDK40592.2 - 4.6e-31 108.0 0.3 1.3e-30 106.6 0.2 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.22 EDK40592.2 - 0.00059 19.2 20.9 0.093 12.4 0.1 8.6 10 0 0 10 10 10 1 IQ calmodulin-binding motif DivIC PF04977.10 EDK40592.2 - 0.64 9.5 6.3 0.41 10.1 0.5 2.8 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.3 EDK40592.2 - 2.2 8.1 14.0 0.42 10.4 2.0 3.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1900 PF08954.6 EDK40593.2 - 1.5e-49 166.9 0.0 4.8e-49 165.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1900) Prefoldin PF02996.12 EDK40593.2 - 0.041 13.5 0.8 0.041 13.5 0.5 1.9 2 0 0 2 2 2 0 Prefoldin subunit WD40 PF00400.27 EDK40593.2 - 0.15 11.9 1.9 0.41 10.6 0.1 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat Fib_alpha PF08702.5 EDK40593.2 - 0.27 11.3 2.4 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF605 PF04652.11 EDK40593.2 - 8.7 5.6 30.2 12 5.1 20.9 1.1 1 0 0 1 1 1 0 Vta1 like LCAT PF02450.10 EDK40594.2 - 3.4e-108 362.0 1.4 3.4e-108 362.0 1.0 2.3 2 1 0 2 2 2 1 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.2 EDK40594.2 - 0.00052 19.7 0.0 0.0011 18.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.5 EDK40594.2 - 0.048 12.5 0.0 0.083 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Ribosomal_S19 PF00203.16 EDK40594.2 - 0.08 12.5 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S19 Med17 PF10156.4 EDK40594.2 - 0.22 9.7 1.4 0.34 9.1 1.0 1.2 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Autophagy_N PF03986.8 EDK40595.2 - 2.4e-51 173.3 0.9 3.9e-51 172.6 0.6 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 EDK40595.2 - 4.9e-22 77.8 0.2 1.1e-21 76.7 0.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 EDK40595.2 - 8.5e-14 50.3 0.3 1.7e-13 49.4 0.2 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Whi5 PF08528.6 EDK40596.2 - 1.2 8.8 11.9 0.069 12.7 3.8 2.3 3 0 0 3 3 3 0 Whi5 like PCI PF01399.22 EDK40597.2 - 2.9e-07 30.7 0.0 5.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 PCI domain TMEM95 PF15203.1 EDK40597.2 - 0.022 14.1 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 TMEM95 family ERG2_Sigma1R PF04622.7 EDK40598.2 - 3.6e-87 291.1 1.8 3.9e-87 291.0 1.3 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein MatE PF01554.13 EDK40599.2 - 1.1e-53 181.1 33.7 1.4e-28 99.5 6.6 3.0 3 0 0 3 3 3 2 MatE CcmH PF03918.9 EDK40599.2 - 0.076 11.9 0.1 0.076 11.9 0.1 2.0 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Cyclin_N PF00134.18 EDK40600.2 - 1.5e-27 95.6 0.0 3.1e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Rot1 PF10681.4 EDK40601.2 - 4.4e-95 317.0 1.5 5.1e-95 316.8 1.1 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VHS PF00790.14 EDK40603.2 - 3.4e-26 91.5 0.1 1e-25 90.0 0.0 1.8 2 0 0 2 2 2 1 VHS domain FYVE PF01363.16 EDK40603.2 - 1.1e-18 66.8 4.6 2e-18 66.0 3.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.15 EDK40603.2 - 0.00077 18.8 1.6 0.00077 18.8 1.1 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif DUF1631 PF07793.6 EDK40603.2 - 0.085 10.9 9.4 0.081 11.0 4.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1631) zf-AN1 PF01428.11 EDK40603.2 - 0.37 10.6 7.8 0.84 9.5 5.4 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger Orn_Arg_deC_N PF02784.11 EDK40604.2 - 8.3e-72 241.3 0.0 1.1e-71 241.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 EDK40604.2 - 7e-31 106.3 0.0 1.5e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Metallophos PF00149.23 EDK40605.2 - 9.8e-41 139.3 0.1 1.5e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1395 PF07160.7 EDK40605.2 - 0.017 14.6 0.1 0.97 8.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1395) Voldacs PF03517.8 EDK40606.2 - 3.6e-22 78.6 0.4 6.4e-22 77.8 0.3 1.4 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Hid1 PF12722.2 EDK40607.2 - 6.5e-146 487.3 22.9 1.3e-126 423.5 12.9 2.1 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein WGG PF10273.4 EDK40608.1 - 1.5e-25 89.0 1.0 3e-25 88.1 0.7 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF4604 PF15377.1 EDK40608.1 - 0.075 13.2 3.6 0.12 12.5 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) EF-1_beta_acid PF10587.4 EDK40608.1 - 1.2 9.3 5.0 3.7 7.7 3.4 1.8 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region RRS1 PF04939.7 EDK40608.1 - 1.7 8.0 5.1 0.8 9.1 0.9 1.9 2 0 0 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) AAA PF00004.24 EDK40609.2 - 5.1e-17 62.2 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 EDK40609.2 - 2.3e-10 40.7 0.0 3.8e-07 30.2 0.0 2.8 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 EDK40609.2 - 1.6e-07 31.4 0.0 4.2e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain BAH PF01426.13 EDK40609.2 - 8e-06 25.6 0.1 2.6e-05 23.9 0.1 1.9 1 0 0 1 1 1 1 BAH domain Arch_ATPase PF01637.13 EDK40609.2 - 5e-05 23.1 3.8 5.2e-05 23.0 0.0 2.9 3 1 0 3 3 3 1 Archaeal ATPase Cdc6_C PF09079.6 EDK40609.2 - 0.0013 18.3 0.1 0.013 15.1 0.1 2.4 2 0 0 2 2 2 1 CDC6, C terminal AAA_17 PF13207.1 EDK40609.2 - 0.0019 18.9 0.0 0.011 16.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EDK40609.2 - 0.0052 16.3 2.8 0.0073 15.9 0.0 2.6 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.1 EDK40609.2 - 0.0077 16.5 0.0 0.024 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK40609.2 - 0.018 14.7 0.0 0.064 13.0 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain NTPase_1 PF03266.10 EDK40609.2 - 0.029 14.1 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 NTPase NACHT PF05729.7 EDK40609.2 - 0.04 13.5 0.0 0.63 9.6 0.0 2.5 1 1 0 1 1 1 0 NACHT domain Ras PF00071.17 EDK40610.2 - 4.9e-27 94.3 1.0 5.6e-27 94.1 0.7 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40610.2 - 4.8e-15 56.0 0.1 1.3e-14 54.7 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 EDK40610.2 - 1e-05 24.7 0.6 1.3e-05 24.4 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 EDK40610.2 - 8.7e-05 21.8 0.1 0.00011 21.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK40610.2 - 0.00074 18.9 0.1 0.00093 18.6 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.15 EDK40610.2 - 0.078 11.6 0.4 0.16 10.6 0.2 1.7 1 1 0 1 1 1 0 G-protein alpha subunit NOG1 PF06858.9 EDK40610.2 - 0.12 12.3 0.4 4 7.3 0.0 2.5 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) Ribosomal_S3Ae PF01015.13 EDK40611.1 - 1.1e-79 266.3 6.8 1.3e-79 266.1 4.7 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family SpoVIF PF14069.1 EDK40611.1 - 0.017 14.8 1.2 0.37 10.5 0.4 2.5 2 0 0 2 2 2 0 Stage VI sporulation protein F C2 PF00168.25 EDK40612.2 - 5e-54 180.1 1.8 3.6e-17 61.9 0.0 5.4 5 0 0 5 5 5 5 C2 domain Zip PF02535.17 EDK40612.2 - 7 5.5 5.6 12 4.7 3.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter FKBP_C PF00254.23 EDK40613.1 - 8.8e-27 92.9 0.1 4.2e-26 90.8 0.0 2.2 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase SprA-related PF12118.3 EDK40613.1 - 2 7.6 29.4 0.93 8.7 3.3 2.1 2 0 0 2 2 2 0 SprA-related family Daxx PF03344.10 EDK40613.1 - 2.1 6.7 68.7 0.46 8.9 17.5 2.2 2 0 0 2 2 2 0 Daxx Family DUF4551 PF15087.1 EDK40613.1 - 8.6 4.5 9.3 13 3.9 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) HMG-CoA_red PF00368.13 EDK40614.2 - 1.1e-158 527.7 1.9 1.5e-158 527.3 1.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 EDK40614.2 - 2.3e-29 102.0 0.1 4.9e-29 101.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 EDK40614.2 - 1e-08 34.7 10.1 2e-08 33.8 7.0 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation DUF1049 PF06305.6 EDK40614.2 - 0.0047 16.3 2.1 0.61 9.5 0.1 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF1049) Cys_Met_Meta_PP PF01053.15 EDK40615.2 - 1.6e-34 118.8 0.0 2.1e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 EDK40615.2 - 0.00095 18.2 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II PDE6_gamma PF04868.7 EDK40615.2 - 0.12 12.2 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Cyt-b5 PF00173.23 EDK40616.1 - 1.3e-11 44.1 0.1 2e-11 43.4 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Whi5 PF08528.6 EDK40616.1 - 0.015 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Whi5 like Zn_clus PF00172.13 EDK40617.2 - 0.012 15.4 11.0 0.022 14.6 7.6 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain SlyX PF04102.7 EDK40617.2 - 0.41 11.0 3.8 0.46 10.8 0.1 3.0 3 0 0 3 3 3 0 SlyX Syntaxin PF00804.20 EDK40617.2 - 0.71 10.0 4.1 2.3 8.4 2.9 1.9 1 0 0 1 1 1 0 Syntaxin Glyco_hydro_47 PF01532.15 EDK40618.2 - 1.2e-162 541.6 0.1 1.4e-162 541.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.9 EDK40618.2 - 0.1 11.9 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 Fmp27_SW PF10305.4 EDK40618.2 - 0.21 12.0 1.5 2 8.8 0.1 2.4 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain bZIP_1 PF00170.16 EDK40619.2 - 1.3e-08 34.6 3.3 2.8e-08 33.5 2.3 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 EDK40619.2 - 0.00072 19.3 4.5 0.00072 19.3 3.1 2.2 2 1 0 2 2 2 1 Basic region leucine zipper Leptin PF02024.10 EDK40619.2 - 0.0094 15.6 0.1 0.018 14.7 0.0 1.3 1 0 0 1 1 1 1 Leptin Aft1_HRA PF11786.3 EDK40619.2 - 0.23 11.7 7.7 0.075 13.2 1.7 2.9 2 1 0 2 2 2 0 Aft1 HRA domain DUF3492 PF11997.3 EDK40619.2 - 1.2 8.6 3.4 1.8 8.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) RR_TM4-6 PF06459.7 EDK40619.2 - 1.3 8.8 9.5 2.8 7.7 6.6 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4613 PF15390.1 EDK40619.2 - 2.1 6.4 10.0 2.9 5.9 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DDRGK PF09756.4 EDK40619.2 - 2.3 7.5 12.6 3.8 6.8 8.8 1.2 1 0 0 1 1 1 0 DDRGK domain GAGA_bind PF06217.7 EDK40619.2 - 3.5 7.5 12.8 6.6 6.6 8.9 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.9 EDK40619.2 - 4.4 5.2 10.3 6.2 4.7 7.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1708 PF08101.6 EDK40620.2 - 1.3e-145 485.4 4.3 1.2e-144 482.2 3.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) Phosphoprotein PF00922.12 EDK40620.2 - 0.018 14.2 2.7 0.033 13.4 1.9 1.3 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein NST1 PF13945.1 EDK40621.2 - 0.11 12.5 5.1 1.9 8.5 0.7 2.7 2 0 0 2 2 2 0 Salt tolerance down-regulator Carn_acyltransf PF00755.15 EDK40623.2 - 3.1e-106 355.7 0.6 3.6e-106 355.5 0.4 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase G_glu_transpept PF01019.16 EDK40624.2 - 6e-85 285.6 0.0 7.3e-85 285.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Bul1_N PF04425.7 EDK40625.2 - 1.1e-104 350.4 1.6 3.4e-102 342.2 1.1 2.2 1 1 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.7 EDK40625.2 - 5e-16 58.7 8.4 3.6e-14 52.6 0.8 4.0 2 1 1 3 3 3 1 Bul1 C terminus Bul1_N PF04425.7 EDK40626.2 - 2.2e-102 342.8 5.8 2.2e-102 342.8 4.0 2.3 1 1 1 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 EDK40626.2 - 3.9e-47 160.7 7.7 3.9e-47 160.7 5.4 2.9 3 0 0 3 3 3 1 Bul1 C terminus TPR_11 PF13414.1 EDK40627.2 - 3.8e-16 58.4 8.3 1.8e-14 53.1 3.3 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 EDK40627.2 - 9.2e-09 34.5 7.3 0.02 14.7 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 EDK40627.2 - 2e-08 33.4 13.1 0.00018 20.9 1.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 EDK40627.2 - 4.1e-06 26.8 8.8 7.7e-06 25.9 6.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EDK40627.2 - 0.0031 17.4 5.1 1 9.3 0.1 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 EDK40627.2 - 0.0089 15.8 5.9 0.033 14.0 0.1 3.2 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat Pox_T4_N PF04491.7 EDK40627.2 - 0.017 14.9 0.4 0.6 9.9 0.0 2.5 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus TPR_8 PF13181.1 EDK40627.2 - 5.6 6.9 9.2 13 5.8 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat INCENP_ARK-bind PF03941.10 EDK40628.2 - 2.7e-17 62.3 0.1 2.7e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region Bul1_N PF04425.7 EDK40629.2 - 9.5e-117 390.2 6.9 7.9e-116 387.1 1.4 2.5 2 1 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 EDK40629.2 - 4.9e-19 68.5 10.1 1.6e-10 40.6 0.9 2.9 2 1 1 3 3 3 2 Bul1 C terminus PGC7_Stella PF15549.1 EDK40629.2 - 0.43 10.5 2.5 3.5 7.6 0.6 2.4 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain PQ-loop PF04193.9 EDK40630.2 - 9.5e-23 79.5 8.8 6.6e-13 47.9 0.6 2.8 2 0 0 2 2 2 2 PQ loop repeat GTP_EFTU PF00009.22 EDK40631.1 - 2.7e-61 206.3 0.4 3.6e-61 205.8 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 EDK40631.1 - 6.4e-26 90.4 0.0 1.8e-25 89.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EDK40631.1 - 1.8e-21 76.0 1.6 5.2e-21 74.5 1.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EDK40631.1 - 2.5e-05 23.8 0.2 7.8e-05 22.2 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 EDK40631.1 - 3.7e-05 23.6 0.0 8.2e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK40631.1 - 0.0033 17.8 0.0 0.006 17.0 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein DisA_N PF02457.11 EDK40631.1 - 0.093 11.8 0.0 0.25 10.4 0.0 1.7 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding PduV-EutP PF10662.4 EDK40631.1 - 0.1 12.0 0.9 10 5.6 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CbiA PF01656.18 EDK40631.1 - 0.2 11.0 1.6 6.2 6.1 0.0 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Apc1 PF12859.2 EDK40632.2 - 1.7e-15 57.1 0.0 1.7e-15 57.1 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 EDK40632.2 - 1.1e-07 31.6 10.0 0.027 14.7 0.0 5.5 5 0 0 5 5 5 4 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.10 EDK40633.2 - 8.1e-77 257.0 0.0 1.1e-74 250.1 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Big_5 PF13205.1 EDK40633.2 - 0.033 14.7 0.5 0.09 13.3 0.4 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain Mob1_phocein PF03637.12 EDK40634.2 - 2e-67 226.2 1.5 2.5e-67 225.8 1.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family RNA_pol PF00940.14 EDK40635.2 - 2.4e-163 543.3 0.1 1.4e-162 540.8 0.0 2.1 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 EDK40635.2 - 5.1e-88 295.3 3.8 6e-88 295.1 1.2 2.2 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal PPR_3 PF13812.1 EDK40635.2 - 0.15 12.4 0.2 8.1 7.0 0.0 3.6 3 0 0 3 3 3 0 Pentatricopeptide repeat domain PPR_2 PF13041.1 EDK40635.2 - 0.73 9.8 2.9 26 4.8 0.0 3.8 5 0 0 5 5 5 0 PPR repeat family Snf7 PF03357.16 EDK40636.2 - 5e-42 143.1 19.9 5e-42 143.1 13.8 1.8 1 1 1 2 2 2 1 Snf7 NuA4 PF09340.5 EDK40636.2 - 0.2 11.3 0.3 0.2 11.3 0.2 2.5 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 FlaC_arch PF05377.6 EDK40636.2 - 0.3 11.0 5.5 8.8 6.3 0.3 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) zf-ZPR1 PF03367.8 EDK40636.2 - 0.66 9.1 8.4 0.028 13.5 1.6 1.8 2 1 0 2 2 2 0 ZPR1 zinc-finger domain CK2S PF15011.1 EDK40636.2 - 0.74 9.5 5.5 6.7 6.4 0.3 3.0 1 1 1 3 3 3 0 Casein Kinase 2 substrate IncA PF04156.9 EDK40636.2 - 1.1 8.8 20.2 7.8 6.0 12.9 2.4 1 1 1 2 2 2 0 IncA protein Enkurin PF13864.1 EDK40636.2 - 6.4 7.0 18.9 2.3 8.4 1.2 3.4 3 1 0 3 3 3 0 Calmodulin-binding Syntaxin PF00804.20 EDK40637.2 - 1.2e-21 76.8 3.3 1.2e-21 76.8 2.3 2.3 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.14 EDK40637.2 - 6.8e-17 60.9 3.0 3.1e-16 58.8 0.6 2.5 2 0 0 2 2 2 1 SNARE domain Sed5p PF11416.3 EDK40637.2 - 1.3e-16 59.6 0.5 3.2e-16 58.4 0.3 1.7 1 0 0 1 1 1 1 Integral membrane protein Sed5p DUF1722 PF08349.6 EDK40637.2 - 0.019 14.8 2.0 0.071 12.9 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) Flagellin_C PF00700.16 EDK40637.2 - 0.03 14.4 2.1 2.4 8.3 0.1 2.7 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region APG17 PF04108.7 EDK40637.2 - 0.16 10.7 6.4 1.2 7.8 1.1 2.1 2 0 0 2 2 2 0 Autophagy protein Apg17 MCPsignal PF00015.16 EDK40637.2 - 0.26 10.8 3.0 0.33 10.4 0.2 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF16 PF01519.11 EDK40637.2 - 0.39 10.9 8.6 1.4 9.1 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 HSBP1 PF06825.7 EDK40637.2 - 0.69 9.5 4.5 3.3 7.3 0.1 3.0 3 1 1 4 4 4 0 Heat shock factor binding protein 1 FlaC_arch PF05377.6 EDK40637.2 - 1 9.2 5.2 0.62 10.0 0.2 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) FliJ PF02050.11 EDK40637.2 - 4.2 7.4 9.4 0.3 11.1 1.6 2.4 2 1 0 2 2 2 0 Flagellar FliJ protein Tubulin PF00091.20 EDK40638.1 - 2.4e-51 174.6 0.0 2.8e-51 174.3 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.1 EDK40638.1 - 0.0018 17.7 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Complex1_LYR PF05347.10 EDK40639.2 - 3.7e-08 33.0 0.4 7.9e-08 31.9 0.2 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EDK40639.2 - 9.2e-08 32.1 0.4 2e-07 31.0 0.2 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 EDK40639.2 - 0.0034 17.8 1.1 0.0065 16.9 0.8 1.4 1 0 0 1 1 1 1 Complex1_LYR-like LuxC PF05893.9 EDK40639.2 - 0.1 11.3 0.3 0.13 10.9 0.2 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) RIC1 PF07064.8 EDK40640.2 - 8.2e-16 58.2 5.8 1.9e-15 57.0 4.0 1.6 1 0 0 1 1 1 1 RIC1 RCC1_2 PF13540.1 EDK40640.2 - 0.077 12.6 0.3 4.4 7.0 0.0 3.1 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Ribosomal_L13e PF01294.13 EDK40641.1 - 5.5e-65 218.1 6.2 7.4e-65 217.7 4.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Arylsulfotrans PF05935.6 EDK40641.1 - 0.082 11.3 0.1 0.1 11.1 0.1 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Ribosomal_60s PF00428.14 EDK40642.1 - 9.6e-24 83.5 11.3 1.2e-23 83.3 7.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MFS_1 PF07690.11 EDK40643.2 - 7.5e-39 133.4 11.9 7.5e-39 133.4 8.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK40643.2 - 8.4e-09 34.5 4.5 8.4e-09 34.5 3.1 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter Cellulase PF00150.13 EDK40644.2 - 9.9e-17 61.0 12.3 1.7e-16 60.3 8.5 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ish1 PF10281.4 EDK40644.2 - 0.036 14.1 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein LIP PF03583.9 EDK40645.1 - 1.2e-108 362.7 0.4 1.5e-108 362.4 0.3 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_5 PF12695.2 EDK40645.1 - 7.2e-06 25.8 0.1 1.9e-05 24.4 0.1 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK40645.1 - 0.00019 21.3 0.0 0.00056 19.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EDK40645.1 - 0.0053 15.9 1.9 0.79 8.9 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family Biotin_carb_C PF02785.14 EDK40645.1 - 0.051 13.5 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain MDM31_MDM32 PF08118.6 EDK40646.2 - 9e-26 90.3 0.1 1.1e-25 90.0 0.1 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins MDM31_MDM32 PF08118.6 EDK40647.2 - 4.6e-150 500.4 4.0 5.1e-150 500.2 2.8 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF202 PF02656.10 EDK40648.1 - 0.01 15.9 4.2 0.038 14.2 2.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF202) COX4_pro_2 PF07835.7 EDK40648.1 - 0.043 13.8 1.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV INO80_Ies4 PF08193.6 EDK40649.2 - 1e-07 32.1 6.7 1e-07 32.1 4.7 2.3 1 1 0 2 2 2 1 INO80 complex subunit Ies4 NAM-associated PF14303.1 EDK40649.2 - 0.11 12.8 20.4 0.14 12.4 14.1 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF4140 PF13600.1 EDK40649.2 - 0.24 11.8 4.0 0.14 12.5 1.2 1.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) SOG2 PF10428.4 EDK40649.2 - 7.6 5.0 9.8 8.7 4.8 6.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein tRNA-synt_2b PF00587.20 EDK40650.2 - 5.8e-49 165.9 0.2 7.6e-49 165.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) CDC73 PF05179.9 EDK40651.2 - 7.1e-54 182.9 0.5 9.2e-54 182.6 0.3 1.1 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family APG17 PF04108.7 EDK40652.2 - 3e-121 405.0 8.4 3.7e-121 404.7 5.8 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 FTCD_C PF04961.7 EDK40652.2 - 0.046 13.1 4.7 2.3 7.6 0.9 2.6 3 0 0 3 3 3 0 Formiminotransferase-cyclodeaminase Tweety PF04906.8 EDK40652.2 - 0.33 9.3 3.8 9.9 4.4 2.2 2.4 2 0 0 2 2 2 0 Tweety ADIP PF11559.3 EDK40652.2 - 0.73 9.7 8.4 0.11 12.4 2.6 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding FliT PF05400.8 EDK40652.2 - 0.76 10.2 8.6 6.6 7.2 3.2 2.8 2 1 0 2 2 2 0 Flagellar protein FliT Pneumo_M2 PF07380.6 EDK40652.2 - 1.3 9.0 4.4 28 4.7 0.0 3.8 4 0 0 4 4 4 0 Pneumovirus M2 protein G-patch PF01585.18 EDK40653.2 - 2e-13 49.8 3.7 3.7e-13 49.0 2.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 EDK40653.2 - 1.2e-07 31.4 0.8 3.1e-07 30.1 0.6 1.7 1 0 0 1 1 1 1 DExH-box splicing factor binding site FHIPEP PF00771.15 EDK40653.2 - 0.052 11.8 0.3 0.07 11.4 0.2 1.2 1 0 0 1 1 1 0 FHIPEP family CHCH PF06747.8 EDK40654.2 - 4.2e-07 29.7 2.0 7e-07 29.0 1.4 1.4 1 0 0 1 1 1 1 CHCH domain DUF2149 PF09919.4 EDK40654.2 - 0.017 15.2 1.4 0.043 13.9 0.0 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) Ras PF00071.17 EDK40655.2 - 1.3e-41 141.6 0.2 2.5e-41 140.7 0.1 1.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 EDK40655.2 - 3.6e-16 59.7 0.0 5.2e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK40655.2 - 9.4e-12 44.5 0.1 1.2e-11 44.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK40655.2 - 1e-08 34.6 0.0 1.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EDK40655.2 - 2.9e-05 23.5 0.1 5.9e-05 22.5 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK40655.2 - 0.00019 21.3 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 EDK40655.2 - 0.012 15.2 0.2 0.66 9.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 EDK40655.2 - 0.012 15.6 0.1 0.26 11.2 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 EDK40655.2 - 0.039 14.1 0.0 0.098 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 EDK40655.2 - 0.1 12.1 0.0 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EDK40655.2 - 0.11 12.1 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Synaptobrevin PF00957.16 EDK40656.1 - 1.8e-15 56.2 0.6 3.3e-15 55.4 0.4 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 EDK40656.1 - 1.2e-14 53.6 0.0 2.1e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain SAM_2 PF07647.12 EDK40657.2 - 2.3e-05 24.1 1.0 5.3e-05 22.9 0.0 2.1 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 EDK40657.2 - 0.0015 18.6 0.1 0.0038 17.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.14 EDK40658.2 - 7.4e-41 140.4 2.6 3.8e-37 128.2 0.2 2.6 2 1 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.17 EDK40658.2 - 0.12 12.4 0.0 0.56 10.2 0.0 2.2 2 0 0 2 2 2 0 HD domain ABC_membrane PF00664.18 EDK40659.2 - 1.6e-51 175.3 39.8 2.7e-29 102.4 4.8 2.6 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK40659.2 - 1.1e-50 171.4 0.2 2e-29 102.6 0.2 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EDK40659.2 - 1.2e-11 44.2 8.3 0.00023 20.4 2.4 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK40659.2 - 1.4e-06 27.7 0.2 0.018 14.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EDK40659.2 - 1.5e-05 24.8 1.0 0.096 12.6 0.1 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.1 EDK40659.2 - 4.9e-05 23.4 0.2 0.45 10.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain FtsK_SpoIIIE PF01580.13 EDK40659.2 - 5.4e-05 22.7 0.0 0.045 13.2 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF258 PF03193.11 EDK40659.2 - 9.4e-05 21.6 0.1 0.088 11.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 EDK40659.2 - 0.0001 21.7 0.0 0.56 9.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 EDK40659.2 - 0.00016 22.1 0.2 0.75 10.2 0.0 3.2 2 0 0 2 2 2 2 Miro-like protein DUF87 PF01935.12 EDK40659.2 - 0.00066 19.5 0.1 0.99 9.1 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_10 PF12846.2 EDK40659.2 - 0.00085 18.8 0.2 0.51 9.7 0.0 2.6 2 1 1 3 3 3 1 AAA-like domain T2SE PF00437.15 EDK40659.2 - 0.0014 17.6 0.0 0.59 8.9 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_21 PF13304.1 EDK40659.2 - 0.002 18.1 23.0 0.15 12.0 0.0 5.8 6 2 1 7 7 5 2 AAA domain AAA_17 PF13207.1 EDK40659.2 - 0.0037 18.0 9.6 1.6 9.5 0.0 4.6 4 1 0 4 4 4 1 AAA domain AAA_23 PF13476.1 EDK40659.2 - 0.0043 17.4 8.9 0.0096 16.2 0.2 3.1 3 1 0 3 3 2 1 AAA domain AAA_30 PF13604.1 EDK40659.2 - 0.0058 16.2 1.3 1.8 8.0 0.5 2.9 2 1 0 2 2 2 1 AAA domain MobB PF03205.9 EDK40659.2 - 0.0073 16.0 0.3 1.8 8.2 0.0 2.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.18 EDK40659.2 - 0.012 15.4 3.8 0.14 12.0 0.0 3.5 4 0 0 4 4 4 0 Dynamin family NACHT PF05729.7 EDK40659.2 - 0.014 15.0 0.0 0.11 12.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 EDK40659.2 - 0.019 15.0 0.1 2.1 8.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 EDK40659.2 - 0.042 14.0 0.6 2 8.6 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 EDK40659.2 - 0.055 12.2 0.0 4.3 6.0 0.0 2.3 2 0 0 2 2 2 0 ArgK protein DUF4335 PF14233.1 EDK40660.2 - 0.0015 18.0 2.5 0.0026 17.2 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4335) CCDC-167 PF15188.1 EDK40660.2 - 0.0026 17.6 0.2 0.0089 15.9 0.1 1.9 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 Spc7 PF08317.6 EDK40660.2 - 0.047 12.3 3.4 0.025 13.2 1.1 1.4 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF148 PF02520.12 EDK40660.2 - 0.064 13.0 1.2 0.16 11.8 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF148 Syntaxin PF00804.20 EDK40660.2 - 0.17 12.0 4.5 0.43 10.7 0.8 2.7 2 1 0 2 2 2 0 Syntaxin DUF1043 PF06295.7 EDK40660.2 - 0.22 11.1 2.2 0.79 9.3 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) AMP-binding PF00501.23 EDK40661.2 - 9e-71 238.4 0.0 1.3e-70 237.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 EDK40661.2 - 4.6e-68 228.8 0.0 1.3e-67 227.3 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein PP-binding PF00550.20 EDK40661.2 - 1.2e-13 51.1 0.0 3.9e-13 49.4 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.1 EDK40661.2 - 2.3e-10 41.2 0.7 9.6e-10 39.2 0.5 2.1 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.16 EDK40661.2 - 5.5e-10 39.0 0.0 9e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PB1 PF00564.19 EDK40661.2 - 0.011 15.3 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 PB1 domain Per1 PF04080.8 EDK40662.2 - 2.6e-104 348.3 17.4 2.6e-104 348.3 12.1 1.4 2 0 0 2 2 2 1 Per1-like TP_methylase PF00590.15 EDK40663.2 - 5.3e-22 78.5 0.1 9.2e-22 77.7 0.1 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases polyprenyl_synt PF00348.12 EDK40664.2 - 2.5e-38 131.4 0.0 3.6e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.11 EDK40664.2 - 0.011 15.0 0.0 0.033 13.4 0.0 1.4 1 1 0 1 1 1 0 Terpene synthase family, metal binding domain DER1 PF04511.10 EDK40665.2 - 1.3e-24 86.8 8.1 4.3e-24 85.1 5.6 1.9 1 1 0 1 1 1 1 Der1-like family VPS9 PF02204.13 EDK40666.2 - 1.3e-08 34.8 0.1 2.4e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RNase_H_2 PF13482.1 EDK40669.2 - 0.001 18.8 3.4 0.0015 18.3 2.4 1.2 1 0 0 1 1 1 1 RNase_H superfamily DUF4158 PF13700.1 EDK40669.2 - 0.023 14.1 3.2 0.033 13.6 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) LRR_4 PF12799.2 EDK40670.2 - 5.3e-10 38.6 13.8 7.2e-05 22.3 0.1 3.6 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK40670.2 - 2.8e-05 23.7 2.8 0.0016 18.1 0.1 3.2 1 1 2 3 3 3 3 Leucine rich repeat F-box-like PF12937.2 EDK40670.2 - 0.0025 17.5 3.0 0.0093 15.6 0.2 3.1 3 0 0 3 3 3 1 F-box-like LRR_6 PF13516.1 EDK40670.2 - 0.012 15.5 15.8 3.1 8.1 1.3 6.2 5 1 0 5 5 5 0 Leucine Rich repeat LRR_7 PF13504.1 EDK40670.2 - 0.023 14.7 12.7 57 4.5 0.0 6.5 6 0 0 6 6 6 0 Leucine rich repeat F-box PF00646.28 EDK40670.2 - 0.029 14.0 0.5 0.029 14.0 0.3 2.2 2 0 0 2 2 2 0 F-box domain FNIP PF05725.7 EDK40670.2 - 0.25 11.3 2.8 8.5 6.4 0.1 3.4 3 0 0 3 3 3 0 FNIP Repeat LRR_1 PF00560.28 EDK40670.2 - 0.63 10.2 18.7 38 4.8 0.0 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat ABC_membrane PF00664.18 EDK40671.2 - 8.6e-51 172.9 7.7 1.1e-50 172.6 5.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 EDK40671.2 - 3.7e-34 117.9 0.0 8.2e-34 116.8 0.0 1.6 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.14 EDK40671.2 - 5.1e-06 25.8 0.3 0.001 18.3 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 EDK40671.2 - 5.5e-06 26.5 0.1 0.0032 17.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 EDK40671.2 - 7.5e-05 22.7 0.0 0.00018 21.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK40671.2 - 0.00018 22.3 0.0 0.00035 21.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 EDK40671.2 - 0.00036 20.6 0.1 0.0056 16.8 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EDK40671.2 - 0.00097 18.8 0.0 0.014 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 EDK40671.2 - 0.0024 18.1 0.0 0.0063 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK40671.2 - 0.0027 17.2 0.1 0.0071 15.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.4 EDK40671.2 - 0.0028 16.3 0.3 0.0049 15.5 0.2 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_33 PF13671.1 EDK40671.2 - 0.01 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 EDK40671.2 - 0.031 14.4 0.0 0.51 10.5 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 EDK40671.2 - 0.039 13.3 0.0 0.49 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EDK40671.2 - 0.046 12.9 0.0 0.087 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 EDK40671.2 - 0.047 13.1 0.0 0.29 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain 6PF2K PF01591.13 EDK40671.2 - 0.059 12.4 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SbcCD_C PF13558.1 EDK40671.2 - 0.072 13.0 2.2 0.26 11.2 0.3 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.13 EDK40671.2 - 0.094 12.1 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sigma54_activ_2 PF14532.1 EDK40671.2 - 0.12 12.4 0.0 0.65 10.0 0.0 2.2 3 0 0 3 3 2 0 Sigma-54 interaction domain Glyco_transf_28 PF03033.15 EDK40672.2 - 6.6e-28 97.2 0.0 1.3e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.15 EDK40672.2 - 2e-19 68.8 5.2 1.1e-14 53.7 0.1 3.1 3 0 0 3 3 3 2 GRAM domain PH PF00169.24 EDK40672.2 - 2.1e-07 31.1 0.3 3.1e-06 27.3 0.0 3.3 4 0 0 4 4 4 1 PH domain UDPGT PF00201.13 EDK40672.2 - 1e-06 27.6 0.0 2.1e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_4_4 PF13579.1 EDK40672.2 - 0.0039 17.3 0.0 0.007 16.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Abhydrolase_1 PF00561.15 EDK40673.2 - 2.2e-47 161.5 0.0 3e-47 161.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK40673.2 - 3.4e-09 36.9 0.0 7e-09 35.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK40673.2 - 0.026 14.2 0.1 0.17 11.6 0.1 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 EDK40673.2 - 0.13 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Zn_clus PF00172.13 EDK40674.2 - 6e-10 38.8 8.2 1e-09 38.1 5.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 EDK40674.2 - 2.1e-09 36.6 0.3 2.8e-08 32.9 0.2 2.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain WD40 PF00400.27 EDK40675.2 - 8.6e-25 85.6 11.5 9.5e-05 22.1 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat Lgl_C PF08596.5 EDK40675.2 - 0.0047 15.4 0.0 0.0098 14.3 0.0 1.5 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal eIF2A PF08662.6 EDK40675.2 - 0.0053 16.4 0.0 4.6 6.8 0.0 2.9 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 EDK40675.2 - 0.055 12.2 0.0 5.5 5.6 0.0 2.9 2 1 1 3 3 3 0 Nup133 N terminal like Thioredoxin PF00085.15 EDK40676.2 - 4.9e-52 173.9 0.4 2.5e-26 91.3 0.0 3.4 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 EDK40676.2 - 1.2e-31 109.9 1.2 2.6e-23 82.7 2.3 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 EDK40676.2 - 4.6e-12 46.1 2.6 3.3e-05 24.0 0.1 4.0 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 EDK40676.2 - 3.3e-09 36.7 0.2 0.0022 18.0 0.0 3.6 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.1 EDK40676.2 - 1.3e-06 28.2 1.8 0.038 14.0 0.0 3.9 4 0 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.16 EDK40676.2 - 2.3e-05 24.0 0.8 0.1 12.2 0.0 3.9 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_9 PF14595.1 EDK40676.2 - 0.00099 18.6 1.4 0.12 11.9 0.0 3.2 4 0 0 4 4 4 1 Thioredoxin Redoxin PF08534.5 EDK40676.2 - 0.006 16.1 0.1 2.6 7.5 0.0 2.7 2 0 0 2 2 2 2 Redoxin Svf1 PF08622.5 EDK40677.2 - 1.9e-82 276.8 1.5 2.3e-82 276.5 1.0 1.0 1 0 0 1 1 1 1 Svf1-like Enhancin PF03272.8 EDK40677.2 - 0.064 11.1 0.0 0.083 10.7 0.0 1.1 1 0 0 1 1 1 0 Viral enhancin protein ABC2_membrane PF01061.19 EDK40678.2 - 1.2e-34 119.3 13.8 1.2e-34 119.3 9.5 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 EDK40678.2 - 2.9e-26 92.4 0.0 5.2e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EDK40678.2 - 3.5e-09 37.0 0.0 2.3e-08 34.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.2 EDK40678.2 - 5.9e-08 32.1 12.0 5.9e-08 32.1 8.3 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein hEGF PF12661.2 EDK40678.2 - 0.004 17.1 16.7 0.0059 16.6 2.5 3.7 3 0 0 3 3 3 2 Human growth factor-like EGF AAA_25 PF13481.1 EDK40678.2 - 0.0078 15.6 0.0 0.83 9.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 EDK40678.2 - 0.014 14.5 0.4 0.037 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_15 PF13175.1 EDK40678.2 - 0.014 14.4 0.0 4.6 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 EDK40678.2 - 0.025 14.0 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.1 EDK40678.2 - 0.029 14.2 0.0 0.086 12.7 0.0 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 EDK40678.2 - 0.062 13.2 0.3 0.1 12.5 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 EDK40678.2 - 0.08 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain UCH PF00443.24 EDK40679.2 - 7.4e-51 172.8 0.5 1.7e-50 171.6 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 EDK40679.2 - 5.7e-41 137.7 11.7 5.2e-16 57.8 0.2 4.6 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.1 EDK40679.2 - 6.2e-12 45.5 3.1 4.8e-06 26.2 0.1 2.6 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase FliD_C PF07195.7 EDK40679.2 - 0.0032 16.8 0.2 0.1 11.8 0.0 2.9 2 1 1 3 3 3 1 Flagellar hook-associated protein 2 C-terminus TMF_DNA_bd PF12329.3 EDK40679.2 - 0.01 15.6 0.4 0.039 13.7 0.1 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BCS1_N PF08740.6 EDK40680.2 - 4.5e-49 166.6 0.0 8e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 EDK40680.2 - 6.5e-23 81.3 0.0 1.1e-22 80.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EDK40680.2 - 8e-06 26.6 0.0 1.7e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK40680.2 - 0.00038 20.7 0.0 0.0012 19.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EDK40680.2 - 0.00055 19.9 0.0 0.00099 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 EDK40680.2 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 EDK40680.2 - 0.0015 18.5 0.1 0.0024 17.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EDK40680.2 - 0.0017 17.3 0.0 0.0027 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 EDK40680.2 - 0.0022 18.1 0.0 0.0067 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 EDK40680.2 - 0.0023 17.6 0.0 0.012 15.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EDK40680.2 - 0.0026 16.8 0.0 0.0045 16.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 EDK40680.2 - 0.0051 15.9 0.0 0.0087 15.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.1 EDK40680.2 - 0.0063 15.9 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 EDK40680.2 - 0.009 16.3 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_14 PF13173.1 EDK40680.2 - 0.0094 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK40680.2 - 0.011 15.1 0.0 0.032 13.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.1 EDK40680.2 - 0.012 15.2 0.1 0.044 13.3 0.0 1.9 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 EDK40680.2 - 0.015 15.4 0.0 0.04 14.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Arch_ATPase PF01637.13 EDK40680.2 - 0.031 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_19 PF13245.1 EDK40680.2 - 0.037 13.7 0.0 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain KaiC PF06745.8 EDK40680.2 - 0.038 13.0 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.7 EDK40680.2 - 0.039 13.6 0.0 0.26 10.9 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Miro PF08477.8 EDK40680.2 - 0.06 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein AAA_11 PF13086.1 EDK40680.2 - 0.064 12.8 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 EDK40680.2 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EDK40680.2 - 0.083 13.2 0.0 0.19 11.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain UPF0079 PF02367.12 EDK40680.2 - 0.09 12.4 0.0 0.55 9.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 HSF_DNA-bind PF00447.12 EDK40681.2 - 1.5e-34 118.2 1.4 2.7e-34 117.4 1.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Tcp11 PF05794.8 EDK40682.2 - 1.7e-159 531.2 1.5 2.2e-159 530.9 1.0 1.1 1 0 0 1 1 1 1 T-complex protein 11 TCTP PF00838.12 EDK40684.2 - 0.1 12.6 4.8 0.33 10.9 0.2 2.3 2 0 0 2 2 2 0 Translationally controlled tumour protein Clathrin_lg_ch PF01086.12 EDK40684.2 - 0.25 11.2 9.7 0.35 10.7 6.7 1.2 1 0 0 1 1 1 0 Clathrin light chain DUF2842 PF11003.3 EDK40684.2 - 0.72 9.7 0.1 0.72 9.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) Glyco_hydro_92 PF07971.7 EDK40685.2 - 6.2e-167 556.2 5.4 7.9e-167 555.9 3.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Pkinase PF00069.20 EDK40686.2 - 7.3e-65 218.6 0.0 1.4e-64 217.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40686.2 - 8.8e-28 97.0 0.0 1.2e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40686.2 - 0.0071 15.3 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK40686.2 - 0.035 13.1 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 EDK40686.2 - 0.12 11.6 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 EDK40686.2 - 0.14 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 EDK40687.2 - 2.4e-71 239.9 0.0 2.9e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40687.2 - 7.3e-29 100.6 0.0 1e-28 100.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40687.2 - 0.00065 18.7 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 EDK40687.2 - 0.0013 17.6 0.2 0.0021 16.9 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.18 EDK40687.2 - 0.0018 18.0 0.1 0.0088 15.8 0.0 1.8 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 EDK40687.2 - 0.019 14.0 0.4 0.057 12.4 0.3 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Lge1 PF11488.3 EDK40688.2 - 9.7e-19 67.3 1.3 9.7e-19 67.3 0.9 1.5 2 0 0 2 2 2 1 Transcriptional regulatory protein LGE1 Tropomyosin PF00261.15 EDK40688.2 - 0.064 12.3 3.3 0.095 11.7 2.3 1.1 1 0 0 1 1 1 0 Tropomyosin ADIP PF11559.3 EDK40688.2 - 0.16 11.9 3.1 0.24 11.2 2.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding adh_short PF00106.20 EDK40689.1 - 3.9e-23 82.2 0.1 5.4e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK40689.1 - 3.8e-11 43.2 0.4 5.7e-11 42.6 0.3 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK40689.1 - 1e-05 25.2 0.1 2.6e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK40689.1 - 1.1e-05 25.5 0.1 2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 EDK40689.1 - 0.0031 16.4 0.5 0.0045 15.9 0.4 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 EDK40689.1 - 0.01 15.9 0.2 0.026 14.6 0.1 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 EDK40689.1 - 0.02 14.5 0.5 0.052 13.2 0.3 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DMP1 PF07263.6 EDK40690.2 - 0.001 17.8 5.8 0.0012 17.6 4.0 1.1 1 0 0 1 1 1 1 Dentin matrix protein 1 (DMP1) NPR3 PF03666.8 EDK40690.2 - 9.2 4.6 8.3 12 4.2 5.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CTDII PF01556.13 EDK40691.2 - 4.1e-25 87.4 0.0 4e-21 74.6 0.0 2.5 2 1 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 EDK40691.2 - 1.9e-23 81.9 0.3 2.9e-23 81.3 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.27 EDK40692.2 - 8e-48 158.6 19.1 1.2e-10 40.8 0.4 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 EDK40692.2 - 5.6e-10 37.9 14.0 0.011 13.9 0.1 4.8 2 1 2 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EDK40692.2 - 0.00011 21.1 3.8 0.02 13.6 0.1 3.3 1 1 1 2 2 2 2 Nup133 N terminal like DUF3312 PF11768.3 EDK40692.2 - 0.00049 18.4 0.4 0.036 12.3 0.0 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3312) VID27 PF08553.5 EDK40692.2 - 0.072 11.3 0.0 0.88 7.7 0.0 2.3 2 0 0 2 2 2 0 VID27 cytoplasmic protein SET PF00856.23 EDK40693.2 - 1.2e-09 38.6 0.0 3e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.13 EDK40693.2 - 0.0061 16.3 17.1 0.0061 16.3 11.9 3.2 3 0 0 3 3 3 1 MYND finger zf-Mss51 PF13824.1 EDK40693.2 - 0.024 14.4 15.1 1.2 9.0 0.5 2.9 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 RFX_DNA_binding PF02257.10 EDK40694.2 - 2e-28 98.3 0.0 5.4e-28 96.9 0.0 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain Cdc6_C PF09079.6 EDK40694.2 - 0.091 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal DUF2497 PF10691.4 EDK40694.2 - 0.12 12.3 0.0 0.42 10.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2497) Ribosomal_L30 PF00327.15 EDK40695.2 - 4e-14 51.9 0.2 8.5e-14 50.8 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF2036 PF09724.4 EDK40696.2 - 1.9e-63 214.5 0.0 2.2e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) Mito_carr PF00153.22 EDK40697.2 - 6.5e-34 115.5 0.1 1.5e-17 63.0 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein RRM_1 PF00076.17 EDK40698.2 - 4.2e-50 167.2 2.0 3.3e-14 52.2 0.0 5.4 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40698.2 - 1e-42 143.9 0.2 2.3e-12 46.7 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40698.2 - 1.4e-16 60.0 0.4 2.6e-06 27.1 0.0 5.3 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trypan_PARP PF05887.6 EDK40698.2 - 0.053 13.3 22.9 0.013 15.3 9.3 2.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) CENP-N PF05238.8 EDK40699.2 - 8.4e-112 374.1 0.0 9.5e-112 373.9 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like HRDC PF00570.18 EDK40699.2 - 0.11 12.2 0.0 0.31 10.7 0.0 1.8 1 0 0 1 1 1 0 HRDC domain Vps16_N PF04841.8 EDK40700.2 - 7.5e-51 172.9 0.3 3.2e-49 167.5 0.2 2.7 1 1 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.7 EDK40700.2 - 3.9e-34 118.0 6.1 2.7e-33 115.3 4.2 2.2 1 1 0 1 1 1 1 Vps16, C-terminal region Skp1_POZ PF03931.10 EDK40701.2 - 1.7e-06 28.0 0.6 1.1e-05 25.3 0.4 2.0 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain DUF1942 PF09167.6 EDK40701.2 - 0.096 12.4 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1942) CLTH PF10607.4 EDK40702.2 - 2.4e-23 82.4 2.7 2.4e-23 82.4 1.9 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 EDK40702.2 - 1.3e-07 31.1 1.1 3.7e-07 29.7 0.0 2.5 2 1 0 2 2 2 1 RING-type zinc-finger PyrI_C PF02748.10 EDK40702.2 - 0.13 11.6 0.6 0.32 10.4 0.4 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain AdoMet_MTase PF07757.8 EDK40703.2 - 9.2e-43 144.9 0.1 1.5e-42 144.1 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.1 EDK40703.2 - 0.16 11.6 0.1 4.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.20 EDK40704.1 - 1.1e-74 250.8 0.0 1.3e-74 250.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40704.1 - 4.9e-35 120.8 0.0 6.4e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40704.1 - 0.0014 17.6 0.1 0.002 17.1 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Fibrillarin_2 PF10113.4 EDK40705.2 - 0.013 13.8 0.0 0.019 13.3 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein CPL PF08144.6 EDK40705.2 - 0.013 15.3 0.0 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 CPL (NUC119) domain PHR PF08005.7 EDK40705.2 - 0.13 12.4 0.1 7.8 6.6 0.0 2.3 2 0 0 2 2 2 0 PHR domain ICL PF00463.16 EDK40706.1 - 1.9e-296 983.3 2.6 2.1e-296 983.1 1.8 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 EDK40706.1 - 6.1e-12 45.2 0.0 4.3e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase PSD5 PF07637.6 EDK40706.1 - 0.076 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1595) PQ-loop PF04193.9 EDK40707.2 - 1e-11 44.1 13.4 7.4e-08 31.8 1.0 3.4 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.13 EDK40707.2 - 0.0035 17.8 1.7 0.0035 17.8 1.2 2.4 2 1 0 2 2 2 1 ER lumen protein retaining receptor MtN3_slv PF03083.11 EDK40707.2 - 0.72 9.7 13.3 0.15 11.9 0.4 2.7 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange zf-C2H2 PF00096.21 EDK40708.2 - 1.4e-07 31.3 1.7 0.0026 17.9 0.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK40708.2 - 1.1e-05 25.4 0.7 0.12 12.7 0.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 EDK40708.2 - 0.038 14.1 0.2 0.13 12.4 0.2 1.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 EDK40708.2 - 0.31 11.4 3.0 5.1 7.5 0.0 2.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 EDK40708.2 - 0.68 10.2 2.9 17 5.8 0.2 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain His_Phos_1 PF00300.17 EDK40709.2 - 3.5e-41 140.9 0.1 6.3e-41 140.1 0.0 1.4 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF3605 PF12239.3 EDK40710.2 - 3.6e-47 160.1 1.3 8.6e-47 158.9 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) Histone PF00125.19 EDK40711.1 - 2.4e-15 56.4 0.2 2.9e-15 56.1 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK40711.1 - 1.7e-05 24.7 0.1 2.9e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.12 EDK40711.1 - 2.1e-05 24.3 0.1 2.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 EDK40711.1 - 2.3e-05 24.5 0.1 3e-05 24.0 0.1 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 EDK40711.1 - 0.00042 19.6 0.0 0.00045 19.5 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 EDK40711.1 - 0.0037 16.9 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 EDK40711.1 - 0.063 13.5 0.1 0.13 12.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.10 EDK40711.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.19 EDK40712.1 - 1.9e-31 108.0 0.5 3.1e-31 107.3 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 EDK40712.1 - 2e-06 27.9 0.0 3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 EDK40712.1 - 0.0058 16.6 0.6 0.0087 16.1 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 EDK40712.1 - 0.056 13.1 0.1 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated DUF3445 PF11927.3 EDK40713.2 - 9.1e-79 264.3 0.0 1.1e-78 264.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Mannosyl_trans2 PF04188.8 EDK40714.2 - 2.2e-50 171.8 30.4 1e-41 143.3 14.0 2.0 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V)) AMP-binding PF00501.23 EDK40715.2 - 1.1e-72 244.7 0.1 1.7e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EDK40715.2 - 2.7e-21 76.2 0.8 1.7e-20 73.7 0.4 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain HSP70 PF00012.15 EDK40716.1 - 3e-271 900.6 10.4 3.4e-271 900.4 7.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 EDK40716.1 - 9.4e-18 63.8 0.0 1.3e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 EDK40716.1 - 0.0018 17.9 0.0 0.0079 15.8 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 EDK40716.1 - 0.003 16.6 0.1 0.029 13.4 0.0 2.3 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase Septin PF00735.13 EDK40717.2 - 5.2e-109 363.6 0.1 5.2e-109 363.6 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 EDK40717.2 - 5.9e-05 22.9 0.0 0.00022 21.1 0.0 2.1 2 2 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.1 EDK40717.2 - 0.00021 21.4 0.2 0.0018 18.4 0.0 2.6 2 2 0 2 2 2 1 AAA domain FeoB_N PF02421.13 EDK40717.2 - 0.0018 17.5 0.0 0.0037 16.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 EDK40717.2 - 0.0053 15.9 0.0 0.012 14.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 EDK40717.2 - 0.006 16.1 0.4 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain Strep_SA_rep PF06696.6 EDK40717.2 - 0.017 14.8 0.6 0.035 13.8 0.4 1.6 1 0 0 1 1 1 0 Streptococcal surface antigen repeat Miro PF08477.8 EDK40717.2 - 0.02 15.3 0.3 0.068 13.6 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein AAA PF00004.24 EDK40717.2 - 0.021 14.9 1.4 0.15 12.2 0.0 2.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 EDK40717.2 - 0.023 14.1 0.5 0.38 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain cobW PF02492.14 EDK40717.2 - 0.048 13.0 0.1 0.12 11.7 0.1 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 EDK40717.2 - 0.049 13.6 0.2 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Phage_GPO PF05929.6 EDK40717.2 - 0.059 12.6 6.3 0.092 11.9 4.3 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase NACHT PF05729.7 EDK40717.2 - 0.066 12.8 0.1 0.36 10.4 0.0 2.1 2 1 0 2 2 2 0 NACHT domain AAA_33 PF13671.1 EDK40717.2 - 0.073 12.9 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 EDK40717.2 - 0.16 12.2 4.6 0.76 10.0 0.1 2.5 2 1 0 2 2 2 0 ABC transporter MAP7 PF05672.6 EDK40717.2 - 0.64 9.3 14.9 1.2 8.4 10.3 1.4 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family AAA_11 PF13086.1 EDK40717.2 - 0.76 9.2 9.1 15 5.0 5.5 2.1 2 0 0 2 2 2 0 AAA domain Remorin_C PF03763.8 EDK40717.2 - 0.8 9.2 13.9 1.6 8.3 9.6 1.4 1 0 0 1 1 1 0 Remorin, C-terminal region IncA PF04156.9 EDK40717.2 - 3.7 7.1 12.9 6.1 6.3 8.9 1.3 1 0 0 1 1 1 0 IncA protein DUF1090 PF06476.7 EDK40717.2 - 6.2 6.5 15.4 12 5.5 10.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Dynamin_N PF00350.18 EDK40717.2 - 7.6 6.3 7.2 0.87 9.3 0.0 2.4 2 2 0 2 2 2 0 Dynamin family CinA PF02464.12 EDK40718.2 - 2.6e-30 104.9 0.0 3.4e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Competence-damaged protein Proteasom_Rpn13 PF04683.8 EDK40719.1 - 4.1e-25 87.6 0.0 5.6e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Pkinase PF00069.20 EDK40720.2 - 2.2e-52 177.8 0.0 3.6e-51 173.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40720.2 - 1.3e-23 83.3 0.0 6.9e-22 77.7 0.0 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40720.2 - 0.00035 19.6 0.0 0.18 10.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 EDK40720.2 - 0.18 11.5 0.0 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3543 PF12063.3 EDK40721.2 - 2.8e-90 301.7 0.3 2.8e-90 301.7 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 EDK40721.2 - 7.6e-65 218.6 0.0 1.6e-64 217.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40721.2 - 1.4e-44 152.1 0.0 2.2e-44 151.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40721.2 - 0.00018 20.6 0.0 0.0025 16.8 0.0 2.4 3 0 0 3 3 3 1 Kinase-like Chorein_N PF12624.2 EDK40722.2 - 9.7e-46 154.1 0.6 2.7e-45 152.7 0.4 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1162 PF06650.7 EDK40724.2 - 2e-81 273.2 4.3 6.4e-81 271.5 0.6 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1162) ATG_C PF09333.6 EDK40724.2 - 0.00035 20.6 0.0 0.00078 19.5 0.0 1.5 1 0 0 1 1 1 1 ATG C terminal domain Formyl_trans_N PF00551.14 EDK40725.2 - 1.2e-31 109.7 0.0 2e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.13 EDK40725.2 - 2.7e-10 40.2 0.1 4.4e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Nodulin-like PF06813.8 EDK40726.2 - 1.7e-17 63.4 6.4 1.7e-17 63.4 4.4 3.1 2 1 1 3 3 3 1 Nodulin-like MFS_1 PF07690.11 EDK40726.2 - 8.5e-10 37.8 33.5 8.5e-10 37.8 23.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PepSY_TM_2 PF13703.1 EDK40726.2 - 0.068 13.3 0.4 0.068 13.3 0.2 4.4 5 1 0 5 5 5 0 PepSY-associated TM helix TRAUB PF08164.7 EDK40727.2 - 0.068 13.2 3.8 0.091 12.8 1.6 1.9 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal Saccharop_dh PF03435.13 EDK40728.2 - 7.1e-05 21.9 0.3 0.0001 21.3 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase ADH_zinc_N PF00107.21 EDK40728.2 - 0.0001 21.8 0.2 0.00027 20.4 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Semialdhyde_dh PF01118.19 EDK40728.2 - 0.00064 20.0 0.1 0.0012 19.1 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 EDK40728.2 - 0.0072 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.15 EDK40728.2 - 0.011 15.6 0.2 0.025 14.4 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CoA_binding PF02629.14 EDK40728.2 - 0.03 14.8 0.3 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 CoA binding domain ADH_zinc_N_2 PF13602.1 EDK40728.2 - 0.05 14.4 0.4 0.58 11.0 0.0 2.4 1 1 1 2 2 2 0 Zinc-binding dehydrogenase Ran-binding PF05508.6 EDK40729.2 - 0.00033 19.6 0.1 0.00037 19.4 0.1 1.1 1 0 0 1 1 1 1 RanGTP-binding protein WD40 PF00400.27 EDK40729.2 - 0.11 12.4 0.1 17 5.4 0.0 2.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Trp_syntA PF00290.15 EDK40730.2 - 3e-89 297.9 0.1 4.3e-89 297.4 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 EDK40730.2 - 4.4e-22 78.6 1.0 6.6e-22 78.1 0.1 1.7 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rrn6 PF10214.4 EDK40731.2 - 8.1e-154 513.6 26.7 2.1e-152 508.9 18.5 2.1 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Spore_III_AB PF09548.5 EDK40731.2 - 1.1 8.9 3.1 11 5.6 0.4 2.3 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Glyco_hydro_63 PF03200.11 EDK40732.2 - 3.4e-273 908.3 0.3 1.3e-272 906.3 0.2 1.7 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 EDK40732.2 - 2.9e-06 26.2 1.3 4.6e-06 25.5 0.9 1.2 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.9 EDK40732.2 - 0.00021 20.1 0.2 0.00067 18.4 0.1 1.8 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Metallophos PF00149.23 EDK40733.2 - 3.4e-07 29.8 9.9 4.7e-07 29.3 5.8 2.1 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.13 EDK40733.2 - 0.025 14.5 0.0 0.092 12.7 0.0 1.9 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain Ribosomal_S4e PF00900.15 EDK40734.1 - 6e-31 105.9 0.2 1.5e-30 104.7 0.1 1.7 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 EDK40734.1 - 8.1e-21 73.5 4.4 2.4e-20 72.0 3.2 1.7 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.20 EDK40734.1 - 3.9e-07 29.4 0.0 7e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 EDK40734.1 - 3.8e-05 23.2 1.2 3.8e-05 23.2 0.8 3.4 4 0 0 4 4 4 1 KOW motif RabGAP-TBC PF00566.13 EDK40735.2 - 7.6e-48 162.8 3.1 7.6e-48 162.8 2.2 2.5 3 0 0 3 3 3 1 Rab-GTPase-TBC domain GAS PF13851.1 EDK40735.2 - 0.0012 18.0 15.5 0.012 14.7 3.1 3.5 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding APG6 PF04111.7 EDK40735.2 - 0.0029 16.7 3.8 0.0029 16.7 2.6 2.6 3 0 0 3 3 3 1 Autophagy protein Apg6 MogR_DNAbind PF12181.3 EDK40735.2 - 0.011 15.4 0.7 0.046 13.4 0.1 2.3 2 0 0 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) LEDGF PF11467.3 EDK40735.2 - 0.021 14.5 2.5 0.043 13.5 0.7 2.4 2 0 0 2 2 1 0 Lens epithelium-derived growth factor (LEDGF) Syntaxin-6_N PF09177.6 EDK40735.2 - 0.031 14.6 16.6 0.25 11.7 0.9 4.6 2 1 2 4 4 4 0 Syntaxin 6, N-terminal DUF972 PF06156.8 EDK40735.2 - 0.033 14.5 1.0 0.033 14.5 0.7 4.8 3 1 2 6 6 5 0 Protein of unknown function (DUF972) Syntaxin PF00804.20 EDK40735.2 - 0.046 13.8 15.7 0.51 10.5 0.1 3.7 2 1 1 3 3 3 0 Syntaxin Reo_sigmaC PF04582.7 EDK40735.2 - 0.052 12.7 3.7 0.4 9.8 0.6 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Microtub_assoc PF07989.6 EDK40735.2 - 0.46 10.3 8.6 0.035 13.9 1.4 2.5 2 0 0 2 2 2 0 Microtubule associated TPR_MLP1_2 PF07926.7 EDK40735.2 - 0.46 10.2 16.5 2.4 7.9 7.4 3.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 EDK40735.2 - 0.8 9.2 22.0 0.014 14.9 3.2 3.2 2 1 1 3 3 3 0 IncA protein DASH_Hsk3 PF08227.6 EDK40735.2 - 1.1 9.5 4.9 7 6.9 0.0 3.7 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like Baculo_PEP_C PF04513.7 EDK40735.2 - 1.2 8.9 11.9 0.67 9.7 0.6 3.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PEP-utilisers_N PF05524.8 EDK40735.2 - 1.3 8.8 10.4 1.7 8.4 4.0 3.2 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal Trypan_PARP PF05887.6 EDK40735.2 - 2.2 8.0 6.1 3.9 7.2 4.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4200 PF13863.1 EDK40735.2 - 2.3 8.1 17.2 4.3 7.2 0.6 3.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) Fib_alpha PF08702.5 EDK40735.2 - 2.9 8.0 15.0 0.074 13.1 2.7 2.9 3 0 0 3 3 2 0 Fibrinogen alpha/beta chain family CCDC-167 PF15188.1 EDK40735.2 - 3.9 7.4 9.1 57 3.7 0.1 3.5 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 CENP-F_leu_zip PF10473.4 EDK40735.2 - 6.7 6.5 21.2 0.053 13.3 3.3 3.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.4 EDK40735.2 - 8.7 6.5 17.5 5.3 7.2 0.7 4.6 4 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LigT_PEase PF02834.11 EDK40736.2 - 0.11 12.4 0.3 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 LigT like Phosphoesterase Zn_clus PF00172.13 EDK40737.2 - 2.1e-09 37.1 15.6 4.6e-09 36.0 10.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.8 EDK40737.2 - 0.0084 16.0 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain UQ_con PF00179.21 EDK40738.2 - 4.5e-24 84.4 0.0 5.3e-24 84.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK40738.2 - 1.1e-06 28.4 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 EDK40738.2 - 5e-05 22.9 0.1 7.1e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 UEV domain RQC PF09382.5 EDK40739.2 - 5.1e-23 80.8 0.0 1.7e-22 79.0 0.0 2.0 1 0 0 1 1 1 1 RQC domain DEAD PF00270.24 EDK40739.2 - 6.4e-23 81.0 0.0 1.6e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK40739.2 - 4.1e-20 71.4 0.0 1e-16 60.5 0.0 3.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain HRDC PF00570.18 EDK40739.2 - 0.0014 18.2 0.0 0.0036 16.9 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Helicase_Sgs1 PF11408.3 EDK40739.2 - 0.052 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase zf-CCCH PF00642.19 EDK40740.2 - 1.7e-20 72.2 14.8 1.5e-12 46.9 1.4 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF966 PF06136.8 EDK40740.2 - 0.0075 15.7 0.9 0.0084 15.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF966) zf-CCCH_2 PF14608.1 EDK40740.2 - 0.039 13.9 13.1 0.12 12.4 0.2 2.7 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type DUF3554 PF12074.3 EDK40741.2 - 3.3e-74 250.3 1.2 3.3e-74 250.3 0.9 6.1 5 3 1 6 6 6 2 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 EDK40741.2 - 7.2e-37 125.5 41.2 6.5e-08 32.7 0.0 16.7 13 3 6 19 19 19 8 HEAT repeats HEAT PF02985.17 EDK40741.2 - 4.2e-30 101.0 29.0 0.017 15.1 0.0 21.9 27 0 0 27 27 27 7 HEAT repeat HEAT_EZ PF13513.1 EDK40741.2 - 2.2e-26 91.6 42.7 0.021 15.3 0.1 19.0 18 3 3 21 21 21 9 HEAT-like repeat CLASP_N PF12348.3 EDK40741.2 - 1.3e-18 67.2 4.5 0.0012 18.2 0.0 9.9 8 3 3 12 12 12 6 CLASP N terminal Vac14_Fab1_bd PF12755.2 EDK40741.2 - 6.3e-16 58.5 1.5 0.27 11.6 0.0 10.0 9 2 3 12 12 12 4 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 EDK40741.2 - 7.2e-16 58.5 0.4 0.0047 16.8 0.0 9.7 9 2 1 11 11 11 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.3 EDK40741.2 - 0.019 14.8 2.6 3.4 7.5 0.1 5.5 6 1 1 7 7 7 0 Domain of unknown function (DUF3385) YpjP PF14005.1 EDK40741.2 - 0.11 12.2 0.0 14 5.4 0.0 3.6 2 0 0 2 2 2 0 YpjP-like protein Cohesin_HEAT PF12765.2 EDK40741.2 - 0.15 12.0 9.6 4.6 7.3 0.1 6.0 6 0 0 6 6 6 0 HEAT repeat associated with sister chromatid cohesion zf-H2C2_2 PF13465.1 EDK40742.2 - 1.2e-08 34.8 19.4 2.5e-05 24.3 3.3 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 EDK40742.2 - 4.1e-07 29.9 15.5 0.00097 19.3 3.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK40742.2 - 0.00022 21.2 12.5 0.059 13.7 2.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger RTA1 PF04479.8 EDK40743.2 - 1e-29 103.6 15.6 2.2e-29 102.5 10.8 1.5 1 1 0 1 1 1 1 RTA1 like protein YqzM PF14141.1 EDK40743.2 - 0.037 13.8 0.6 0.037 13.8 0.4 4.6 6 0 0 6 6 6 0 YqzM-like protein PsbN PF02468.10 EDK40743.2 - 5.8 6.6 6.9 1.9 8.1 0.0 3.1 3 0 0 3 3 3 0 Photosystem II reaction centre N protein (psbN) Fungal_trans PF04082.13 EDK40744.1 - 6.3e-17 61.3 0.4 6.3e-17 61.3 0.2 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK40744.1 - 5.4e-06 26.2 14.5 5.4e-06 26.2 10.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.19 EDK40745.2 - 5.7e-84 282.2 34.9 6.6e-84 282.0 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40745.2 - 1.7e-25 89.4 43.6 5.2e-20 71.4 19.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.8 EDK40745.2 - 0.083 12.9 0.6 0.33 10.9 0.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CN_hydrolase PF00795.17 EDK40746.2 - 4.7e-09 35.8 0.0 1.4e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.17 EDK40747.2 - 2.8e-31 108.2 0.0 3.7e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RRM_1 PF00076.17 EDK40748.2 - 5.8e-32 109.1 0.5 1e-15 57.1 0.0 3.7 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40748.2 - 1.1e-21 76.5 0.1 1.1e-09 38.1 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40748.2 - 3.1e-17 62.1 0.2 2.6e-09 36.7 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK40748.2 - 0.00032 20.4 0.0 2 8.2 0.0 3.5 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EDK40748.2 - 0.011 15.5 0.1 0.56 10.0 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif Zn_clus PF00172.13 EDK40749.1 - 3.7e-09 36.3 10.7 5.8e-09 35.7 7.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EBV-NA3 PF05009.7 EDK40749.1 - 0.026 13.7 0.1 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Fungal_trans PF04082.13 EDK40750.2 - 1.3e-14 53.6 0.6 2.3e-14 52.9 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Abhydrolase_5 PF12695.2 EDK40751.1 - 1.2e-10 41.2 0.0 1.7e-09 37.5 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK40751.1 - 3.6e-10 40.1 0.0 5.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK40751.1 - 5e-06 26.2 0.0 1.6e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 EDK40751.1 - 0.00053 19.3 0.0 0.0013 18.0 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.6 EDK40751.1 - 0.0016 18.2 0.0 0.005 16.5 0.0 1.7 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.13 EDK40751.1 - 0.0019 17.6 0.0 0.0022 17.4 0.0 1.3 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.16 EDK40751.1 - 0.049 12.8 0.0 0.28 10.3 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family JAB PF01398.16 EDK40752.2 - 5.9e-27 93.6 1.2 9.7e-27 92.9 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 EDK40752.2 - 5.1e-07 29.2 0.0 1.3e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain CDC45 PF02724.9 EDK40752.2 - 0.034 12.2 11.8 0.044 11.8 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF_4G1 PF12152.3 EDK40752.2 - 0.053 13.4 0.3 2.2 8.2 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 4G1 UPF0172 PF03665.8 EDK40752.2 - 0.37 10.2 5.3 0.54 9.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) UCH PF00443.24 EDK40753.2 - 9.7e-58 195.3 5.0 1.2e-57 195.0 3.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK40753.2 - 9.4e-13 48.2 9.6 2.8e-12 46.7 6.7 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.1 EDK40753.2 - 0.0046 16.2 3.1 0.013 14.7 0.3 2.8 3 1 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase Yippee-Mis18 PF03226.9 EDK40754.2 - 4.1e-14 52.3 0.1 5.9e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.13 EDK40754.2 - 0.0012 18.5 0.1 0.61 9.7 0.0 2.5 2 1 1 3 3 3 2 SelR domain Rsm1 PF08600.5 EDK40754.2 - 0.0099 15.7 0.6 0.12 12.2 0.0 2.1 2 0 0 2 2 2 1 Rsm1-like Transp_Tc5_C PF04236.10 EDK40754.2 - 0.017 15.2 0.3 0.017 15.2 0.2 2.3 3 0 0 3 3 3 0 Tc5 transposase C-terminal domain DNA_RNApol_7kD PF03604.8 EDK40754.2 - 0.33 10.4 3.0 1.8 8.1 0.1 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit PP28 PF10252.4 EDK40755.2 - 0.01 15.8 2.8 0.017 15.1 1.9 1.3 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 DUF3527 PF12043.3 EDK40755.2 - 0.1 12.0 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) Ribosomal_L22 PF00237.14 EDK40756.2 - 2.8e-19 68.9 0.0 4.4e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Baculo_11_kDa PF06143.6 EDK40757.1 - 0.0073 15.6 0.7 2.5 7.5 0.4 2.3 2 0 0 2 2 2 2 Baculovirus 11 kDa family TraQ PF09679.5 EDK40757.1 - 0.32 10.9 1.7 0.71 9.8 0.2 2.0 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Flo11 PF10182.4 EDK40758.2 - 2.9e-44 150.3 3.3 2.9e-44 150.3 2.3 2.1 2 0 0 2 2 2 1 Flo11 domain SHR3_chaperone PF08229.6 EDK40759.1 - 4.7e-80 267.1 0.1 5.6e-80 266.9 0.1 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 Ras PF00071.17 EDK40760.2 - 6.9e-55 184.8 0.0 8.1e-55 184.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK40760.2 - 3.8e-14 53.1 0.0 5.9e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK40760.2 - 1.2e-07 31.1 0.0 1.6e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RRM_1 PF00076.17 EDK40761.2 - 3.9e-09 36.0 0.0 7.9e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40761.2 - 9.9e-08 31.8 0.1 2.2e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.9 EDK40761.2 - 0.021 12.8 8.9 0.025 12.6 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.2 EDK40761.2 - 1.1 6.8 5.3 0.93 7.0 3.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YaaC PF14175.1 EDK40761.2 - 3.6 6.4 5.5 6.8 5.5 3.8 1.4 1 0 0 1 1 1 0 YaaC-like Protein SOBP PF15279.1 EDK40761.2 - 3.9 7.7 8.7 5.3 7.3 6.0 1.3 1 1 0 1 1 1 0 Sine oculis-binding protein WD40 PF00400.27 EDK40762.2 - 5.7e-15 54.5 4.9 7.8e-05 22.4 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat adh_short PF00106.20 EDK40763.2 - 4.5e-12 46.2 0.0 7.4e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK40763.2 - 2e-07 30.8 0.0 3.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.7 EDK40763.2 - 0.064 12.1 0.6 0.12 11.2 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein Pkinase PF00069.20 EDK40764.2 - 1e-62 211.6 0.0 1.5e-62 211.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40764.2 - 1.7e-22 79.7 0.0 2.5e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK40764.2 - 0.054 13.2 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4014 PF13198.1 EDK40765.2 - 0.14 12.5 0.9 2.7 8.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4014) Ribosomal_L11 PF00298.14 EDK40766.2 - 2.7e-26 91.4 0.3 5.2e-26 90.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.9 EDK40766.2 - 3.9e-25 87.0 0.4 6.6e-25 86.3 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain RE_XcyI PF09571.5 EDK40767.2 - 6.7 5.4 6.1 1.2 7.9 1.3 1.7 2 0 0 2 2 2 0 XcyI restriction endonuclease Cwf_Cwc_15 PF04889.7 EDK40767.2 - 7.4 6.2 17.3 8.1 6.0 12.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BTV_NS2 PF04514.7 EDK40767.2 - 8.3 5.1 11.2 8.4 5.1 7.8 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 FAM176 PF14851.1 EDK40767.2 - 9.6 5.8 14.7 1.6 8.3 7.6 1.6 1 1 0 1 1 1 0 FAM176 family WD40 PF00400.27 EDK40769.2 - 8.1e-18 63.5 13.1 6.2e-07 29.0 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 EDK40769.2 - 0.11 12.2 0.2 48 3.5 0.0 3.7 3 1 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A PP1_bind PF15276.1 EDK40769.2 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein phosphatase 1 binding GDC-P PF02347.11 EDK40770.2 - 1.2e-191 637.0 0.0 1.7e-177 590.4 0.0 2.3 2 0 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.16 EDK40770.2 - 0.00014 21.1 0.0 0.00024 20.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 EDK40770.2 - 0.055 11.7 0.2 0.25 9.5 0.0 2.1 3 0 0 3 3 3 0 Cys/Met metabolism PLP-dependent enzyme GTP_EFTU PF00009.22 EDK40771.1 - 3.6e-58 196.1 0.0 4.6e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 EDK40771.1 - 3.2e-14 52.8 2.3 3.2e-14 52.8 1.6 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EDK40771.1 - 0.00052 19.9 0.4 0.0017 18.3 0.3 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 EDK40771.1 - 0.0023 17.5 1.2 0.0051 16.4 0.9 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 CBS PF00571.23 EDK40772.2 - 3.7e-19 68.2 0.1 3.1e-05 23.6 0.0 5.3 5 0 0 5 5 5 5 CBS domain FA_desaturase PF00487.19 EDK40773.2 - 4.8e-19 68.8 17.8 4.8e-19 68.8 12.3 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 EDK40773.2 - 2.1e-14 53.0 0.0 4.6e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 EDK40773.2 - 5.8 7.3 20.4 7.8 6.9 6.3 3.4 2 1 1 3 3 3 0 Fatty acid hydroxylase superfamily Glyco_hydro_31 PF01055.21 EDK40774.2 - 1.7e-125 419.3 0.0 2.1e-125 419.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 EDK40774.2 - 1e-22 79.7 0.4 8.9e-22 76.7 0.5 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like Sugar_tr PF00083.19 EDK40775.2 - 3.6e-63 213.7 17.3 4.7e-63 213.3 12.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40775.2 - 3.3e-22 78.7 18.4 5e-22 78.0 12.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 EDK40775.2 - 3e-06 25.9 17.2 0.00013 20.5 0.8 3.0 3 0 0 3 3 3 2 MFS/sugar transport protein GPP34 PF05719.6 EDK40775.2 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) Sugar_tr PF00083.19 EDK40776.2 - 1.2e-78 264.7 17.3 1.4e-78 264.5 12.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40776.2 - 8.9e-27 93.7 36.8 2.3e-25 89.0 15.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK40776.2 - 0.00027 19.4 21.7 0.00072 18.0 0.3 3.4 3 1 1 4 4 4 2 MFS/sugar transport protein Pro_isomerase PF00160.16 EDK40777.1 - 8.5e-46 155.9 0.2 9.6e-46 155.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Redoxin PF08534.5 EDK40778.1 - 6.7e-29 100.3 0.1 7.7e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 EDK40778.1 - 6.8e-07 29.0 0.0 9.1e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Avl9 PF09794.4 EDK40779.2 - 9.2e-135 448.9 4.0 1.1e-134 448.6 2.8 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.4 EDK40779.2 - 1.2e-09 37.8 4.4 5.3e-09 35.7 3.0 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.5 EDK40779.2 - 3.8e-07 29.7 1.5 0.00047 19.8 1.0 2.7 1 1 0 1 1 1 1 Stabilization of polarity axis DENN PF02141.16 EDK40779.2 - 4.6e-05 23.2 3.6 0.00024 20.8 2.1 2.1 2 0 0 2 2 2 1 DENN (AEX-3) domain WD40 PF00400.27 EDK40780.1 - 3.6e-06 26.6 0.2 0.069 13.0 0.1 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat Lactonase PF10282.4 EDK40780.1 - 0.0042 16.2 0.1 0.095 11.7 0.0 2.5 3 0 0 3 3 3 1 Lactonase, 7-bladed beta-propeller PQQ_2 PF13360.1 EDK40780.1 - 0.0062 16.0 0.0 0.15 11.4 0.0 2.3 2 0 0 2 2 2 1 PQQ-like domain ABC_membrane PF00664.18 EDK40781.2 - 5.2e-82 275.3 38.8 6.5e-49 166.7 2.5 2.7 3 1 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 EDK40781.2 - 6e-47 159.3 0.1 4.4e-28 98.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 EDK40781.2 - 6.8e-08 32.0 7.8 0.0022 17.2 2.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 EDK40781.2 - 2.2e-06 27.7 2.1 0.022 14.7 0.1 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_25 PF13481.1 EDK40781.2 - 0.00018 20.9 0.1 0.096 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 EDK40781.2 - 0.00023 21.6 1.6 0.59 10.6 0.0 3.3 3 0 0 3 3 3 2 Miro-like protein AAA_29 PF13555.1 EDK40781.2 - 0.00024 20.5 0.9 0.7 9.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 EDK40781.2 - 0.00025 20.9 3.0 0.2 11.6 0.2 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_23 PF13476.1 EDK40781.2 - 0.00036 20.9 0.6 0.21 11.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_10 PF12846.2 EDK40781.2 - 0.0007 19.1 2.0 0.46 9.8 0.0 3.1 3 1 0 4 4 4 2 AAA-like domain AAA_21 PF13304.1 EDK40781.2 - 0.0013 18.7 8.6 0.58 10.0 0.1 4.8 3 2 1 4 4 3 1 AAA domain DUF258 PF03193.11 EDK40781.2 - 0.0015 17.7 0.8 0.58 9.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.12 EDK40781.2 - 0.0026 17.5 0.7 1.1 9.0 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_30 PF13604.1 EDK40781.2 - 0.01 15.4 1.5 3.7 7.0 0.7 3.2 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 EDK40781.2 - 0.011 14.8 0.9 5.2 6.1 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin T2SE PF00437.15 EDK40781.2 - 0.013 14.4 0.1 0.24 10.2 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ArgK PF03308.11 EDK40781.2 - 0.016 14.0 0.1 0.061 12.0 0.0 1.9 2 0 0 2 2 2 0 ArgK protein MobB PF03205.9 EDK40781.2 - 0.022 14.4 0.8 6 6.5 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 EDK40781.2 - 0.023 13.7 0.2 0.059 12.4 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 EDK40781.2 - 0.06 14.1 0.9 7.5 7.4 0.2 3.0 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 EDK40781.2 - 0.074 12.8 2.4 0.71 9.6 0.2 2.6 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.1 EDK40781.2 - 0.075 13.3 0.0 20 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 EDK40781.2 - 0.078 12.4 0.1 11 5.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.7 EDK40781.2 - 0.13 11.9 0.6 0.81 9.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 EDK40781.2 - 0.27 11.3 1.7 18 5.4 0.0 3.3 2 1 0 2 2 2 0 AAA domain Sec1 PF00995.18 EDK40782.2 - 9e-104 348.1 0.0 1.1e-103 347.8 0.0 1.1 1 0 0 1 1 1 1 Sec1 family TPT PF03151.11 EDK40783.2 - 3.1e-31 108.1 14.7 3.1e-31 108.1 10.2 2.7 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 EDK40783.2 - 1.2e-13 50.7 18.1 1.2e-13 50.7 12.6 1.5 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.15 EDK40783.2 - 0.00071 19.6 13.0 0.00071 19.6 9.0 3.3 3 1 0 3 3 3 2 EamA-like transporter family DUF3754 PF12576.3 EDK40783.2 - 0.84 9.2 10.2 0.33 10.5 2.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3754) Asp PF00026.18 EDK40784.2 - 3.7e-21 75.6 0.0 9e-21 74.4 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Melibiase PF02065.13 EDK40785.2 - 4.8e-35 121.0 0.0 9.9e-20 70.5 0.0 2.1 1 1 1 2 2 2 2 Melibiase MFS_1 PF07690.11 EDK40786.2 - 2.5e-41 141.6 48.7 4.9e-40 137.3 32.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK40786.2 - 2.5e-15 55.7 28.4 3.3e-15 55.3 19.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 EDK40786.2 - 8.3e-09 34.5 18.3 8.3e-09 34.5 12.7 2.9 1 1 1 3 3 3 1 Sugar (and other) transporter Tic22 PF04278.7 EDK40786.2 - 0.1 11.8 0.2 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Tic22-like family Pox_A14 PF05767.7 EDK40786.2 - 1.1 9.2 6.1 0.17 11.8 0.5 2.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 MFS_1 PF07690.11 EDK40787.2 - 1.7e-25 89.4 29.3 3.1e-14 52.4 8.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.3 EDK40787.2 - 3.4e-06 25.8 25.1 4.1e-05 22.2 7.4 2.5 2 1 0 2 2 2 2 Vacuole effluxer Atg22 like MFS_2 PF13347.1 EDK40787.2 - 2.5e-05 22.8 30.8 0.00018 20.0 7.0 2.9 2 1 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.19 EDK40787.2 - 2.7e-05 22.9 19.0 5.6e-05 21.8 10.3 2.0 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.2 EDK40787.2 - 6.4e-05 22.6 1.7 0.00049 19.8 0.2 3.0 3 0 0 3 3 3 1 MFS_1 like family Mu-like_gpT PF10124.4 EDK40787.2 - 0.1 11.5 0.0 1.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Mu-like prophage major head subunit gpT MFS_1 PF07690.11 EDK40788.2 - 3e-30 105.1 42.5 3e-30 105.1 29.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Ferric_reduct PF01794.14 EDK40789.2 - 1.2e-16 60.9 1.6 1.2e-16 60.9 1.1 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EDK40789.2 - 1.5e-12 47.3 0.0 3.4e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EDK40789.2 - 3e-12 46.7 0.0 6e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF905 PF06006.7 EDK40789.2 - 0.016 14.5 0.1 0.037 13.3 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) NAD_binding_1 PF00175.16 EDK40789.2 - 0.12 12.9 0.0 0.44 11.1 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DUF4405 PF14358.1 EDK40789.2 - 0.5 10.5 6.9 0.41 10.8 0.4 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Glyco_hydro_114 PF03537.8 EDK40790.2 - 3.5e-25 87.5 0.1 5.7e-25 86.8 0.1 1.3 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 DUF1148 PF06618.6 EDK40791.2 - 0.061 13.2 0.1 0.12 12.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1148) NmrA PF05368.8 EDK40792.2 - 2.7e-09 36.6 0.2 4.1e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 EDK40792.2 - 3.7e-09 36.8 0.0 5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK40792.2 - 7.2e-09 35.4 0.0 6.6e-07 28.9 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EDK40792.2 - 7.4e-08 31.6 0.1 1.1e-07 31.0 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.19 EDK40792.2 - 8.4e-07 29.3 0.1 1.5e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EDK40792.2 - 1.4e-06 27.2 0.0 5.7e-05 21.9 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EDK40792.2 - 1.6e-06 27.2 0.2 4.1e-06 25.8 0.1 1.9 2 1 0 2 2 2 1 Male sterility protein Saccharop_dh PF03435.13 EDK40792.2 - 4.9e-05 22.4 0.1 6.9e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase DXP_reductoisom PF02670.11 EDK40792.2 - 0.003 18.1 0.2 0.006 17.1 0.2 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.15 EDK40792.2 - 0.0055 16.6 0.1 0.009 15.9 0.1 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 EDK40792.2 - 0.0056 17.0 0.3 0.013 15.9 0.2 1.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.20 EDK40792.2 - 0.06 13.2 0.1 0.16 11.8 0.1 1.8 1 1 0 1 1 1 0 short chain dehydrogenase GFO_IDH_MocA PF01408.17 EDK40792.2 - 0.11 13.0 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.19 EDK40793.1 - 1e-131 439.6 21.7 1.2e-131 439.4 15.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40793.1 - 2e-24 85.9 20.6 2e-24 85.9 14.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Epimerase PF01370.16 EDK40794.2 - 1.4e-22 80.3 0.0 1.8e-22 79.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK40794.2 - 2.2e-14 52.8 0.0 2.9e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK40794.2 - 3.1e-11 43.6 0.0 4.5e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK40794.2 - 3.1e-06 26.2 0.0 0.00029 19.8 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EDK40794.2 - 5.4e-06 26.4 0.0 1e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 EDK40794.2 - 0.00042 19.6 0.1 0.0029 16.9 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.15 EDK40794.2 - 0.025 14.5 0.1 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 EDK40794.2 - 0.061 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF867 PF05908.6 EDK40794.2 - 0.072 12.1 0.1 1.1 8.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF867) CRCB PF02537.10 EDK40795.2 - 1.5e-32 111.9 29.1 1.1e-22 80.1 7.5 3.1 3 1 0 3 3 3 2 CrcB-like protein Synapsin_N PF10581.4 EDK40795.2 - 0.37 10.6 2.9 26 4.7 0.1 3.3 3 0 0 3 3 3 0 Synapsin N-terminal DUF2842 PF11003.3 EDK40795.2 - 2 8.3 9.5 1.1 9.1 2.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2842) FMN_bind_2 PF04299.7 EDK40796.2 - 6.1e-61 204.7 0.4 8.2e-61 204.3 0.3 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain LMP PF04778.7 EDK40796.2 - 0.024 14.4 0.5 0.05 13.3 0.1 1.7 2 1 0 2 2 2 0 LMP repeated region Pyridox_oxidase PF01243.15 EDK40796.2 - 0.088 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase RRM_1 PF00076.17 EDK40797.1 - 9.4e-17 60.4 0.0 1.6e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40797.1 - 6.5e-15 54.8 0.0 1e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40797.1 - 3.4e-07 30.0 0.0 6.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Guanylate_kin PF00625.16 EDK40797.1 - 0.026 13.9 0.9 0.035 13.5 0.6 1.2 1 0 0 1 1 1 0 Guanylate kinase Pox_A_type_inc PF04508.7 EDK40797.1 - 0.27 11.1 0.3 0.27 11.1 0.2 2.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Oxysterol_BP PF01237.13 EDK40797.1 - 0.31 9.4 2.2 0.43 9.0 1.5 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein API5 PF05918.6 EDK40797.1 - 5.5 5.3 6.6 7.9 4.8 4.6 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Fasciclin PF02469.17 EDK40798.2 - 3.9e-21 75.3 2.1 6.9e-09 35.7 0.0 4.9 5 1 0 5 5 5 3 Fasciclin domain Aa_trans PF01490.13 EDK40799.2 - 1.6e-61 208.0 27.1 2e-61 207.7 18.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TPT PF03151.11 EDK40800.2 - 5.7e-10 39.0 27.3 1.9e-06 27.5 6.4 2.6 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 EDK40800.2 - 8.6e-08 32.2 4.7 8.6e-08 32.2 3.3 3.8 3 2 1 4 4 4 2 EamA-like transporter family DUF914 PF06027.7 EDK40800.2 - 0.00025 20.0 12.1 0.00025 20.0 8.4 1.5 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) UAA PF08449.6 EDK40800.2 - 0.0038 16.1 17.8 0.0066 15.4 12.3 1.5 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 EDK40800.2 - 0.017 15.3 1.2 0.017 15.3 0.8 3.6 3 1 1 4 4 4 0 Multidrug resistance efflux transporter PepSY_TM_2 PF13703.1 EDK40800.2 - 0.92 9.7 15.2 0.064 13.4 4.7 3.5 3 1 0 3 3 3 0 PepSY-associated TM helix OST3_OST6 PF04756.8 EDK40801.2 - 9.7e-13 47.9 4.0 9.7e-13 47.9 2.8 1.9 2 0 0 2 2 2 1 OST3 / OST6 family DUF4131 PF13567.1 EDK40801.2 - 1.5 8.1 8.4 6.5 6.1 0.0 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF4131) UDG PF03167.14 EDK40802.2 - 1.7e-19 69.7 0.0 4.1e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Mannosyl_trans3 PF11051.3 EDK40803.2 - 3.3e-83 279.1 0.0 4.6e-83 278.6 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative SNF2_N PF00176.18 EDK40804.2 - 2.4e-81 272.8 0.1 4.1e-81 272.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 EDK40804.2 - 2.8e-44 149.6 0.9 2.8e-44 149.6 0.6 2.7 4 0 0 4 4 4 1 SLIDE HAND PF09110.6 EDK40804.2 - 2e-37 128.0 4.3 2e-37 128.0 3.0 3.2 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 EDK40804.2 - 9.9e-16 57.3 0.0 1.1e-14 53.9 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK40804.2 - 7.4e-10 38.9 3.1 3.4e-09 36.7 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK40804.2 - 2.9e-05 23.6 0.0 0.00014 21.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.26 EDK40804.2 - 0.0085 16.1 0.0 0.044 13.8 0.0 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA_22 PF13401.1 EDK40804.2 - 0.36 10.9 4.6 1.1 9.3 0.0 3.9 5 1 0 5 5 5 0 AAA domain DOT1 PF08123.8 EDK40806.2 - 1.3e-69 233.6 0.1 3.3e-69 232.3 0.1 1.7 2 0 0 2 2 2 1 Histone methylation protein DOT1 Daxx PF03344.10 EDK40807.2 - 0.51 8.7 23.0 0.72 8.2 16.0 1.2 1 0 0 1 1 1 0 Daxx Family PALP PF00291.20 EDK40808.2 - 8.5e-56 189.4 0.1 1e-55 189.1 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rad33 PF08730.5 EDK40809.2 - 3.6e-45 153.5 0.0 4.6e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Rad33 EMP24_GP25L PF01105.19 EDK40811.2 - 1.1e-44 152.3 0.3 1.4e-44 151.9 0.2 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DASH_Dad2 PF08654.5 EDK40811.2 - 0.019 14.9 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad2 DUF3209 PF11483.3 EDK40811.2 - 0.077 13.3 0.8 0.16 12.2 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) M16C_assoc PF08367.6 EDK40812.2 - 1.7e-74 249.7 1.9 2.6e-74 249.2 1.3 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 EDK40812.2 - 4.4e-09 36.2 0.1 0.0014 18.3 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EDK40813.2 - 1.9e-09 37.4 0.1 4.5e-09 36.2 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Mito_carr PF00153.22 EDK40814.2 - 3.8e-58 193.1 5.7 1e-18 66.8 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1049 PF06305.6 EDK40814.2 - 0.037 13.5 0.1 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) zf-MYND PF01753.13 EDK40815.2 - 4.9e-07 29.5 19.5 1.1e-06 28.3 13.5 1.6 1 0 0 1 1 1 1 MYND finger DUF2424 PF10340.4 EDK40816.2 - 2.6e-24 85.5 0.6 1.4e-23 83.1 0.4 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EDK40816.2 - 2.5e-16 59.9 0.0 3.4e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK40816.2 - 0.00019 21.2 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 EDK40816.2 - 0.098 12.8 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF2737 PF10930.3 EDK40817.2 - 0.063 12.8 7.3 1.9 8.1 3.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2737) Glyco_hydro_76 PF03663.9 EDK40818.2 - 6.2e-21 75.1 10.6 7.6e-21 74.9 7.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF240 PF03086.9 EDK40818.2 - 0.25 10.9 1.5 1.8 8.2 0.1 2.6 2 1 1 3 3 3 0 MG032/MG096/MG288 family 2 DUF2401 PF10287.4 EDK40819.2 - 7.4e-89 297.2 5.3 1.4e-88 296.3 3.7 1.4 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 EDK40819.2 - 5.9e-25 87.2 0.1 1.5e-24 85.9 0.1 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) CelD_N PF02927.9 EDK40819.2 - 0.19 12.0 2.2 3.7 7.8 0.0 3.4 4 0 0 4 4 4 0 N-terminal ig-like domain of cellulase Muted PF14942.1 EDK40820.2 - 0.0045 16.8 9.4 0.0045 16.8 6.5 2.7 1 1 2 3 3 3 1 Organelle biogenesis, Muted-like protein DUF3584 PF12128.3 EDK40820.2 - 0.01 13.2 20.7 0.013 12.9 14.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) UPF0242 PF06785.6 EDK40820.2 - 0.045 12.4 14.9 0.074 11.7 10.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Baculo_PEP_C PF04513.7 EDK40820.2 - 0.24 11.2 12.8 2.3 8.0 4.5 3.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 EDK40820.2 - 0.8 9.2 32.6 0.11 12.0 10.1 3.7 2 1 2 4 4 4 0 IncA protein Tropomyosin PF00261.15 EDK40820.2 - 1.1 8.3 28.2 3.9 6.5 19.6 1.8 1 1 0 1 1 1 0 Tropomyosin DUF4472 PF14739.1 EDK40820.2 - 2.4 8.6 21.3 0.054 13.9 3.4 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DUF4407 PF14362.1 EDK40820.2 - 2.5 6.9 16.7 6 5.7 11.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.14 EDK40820.2 - 2.7 5.7 19.1 5.3 4.7 13.0 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Spectrin PF00435.16 EDK40820.2 - 3.2 8.1 16.0 6.5 7.0 1.7 3.0 1 1 2 3 3 3 0 Spectrin repeat TPR_MLP1_2 PF07926.7 EDK40820.2 - 4.4 7.0 29.8 0.024 14.3 8.7 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TBPIP PF07106.8 EDK40820.2 - 6.4 6.2 27.5 0.071 12.6 8.8 3.0 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fib_alpha PF08702.5 EDK40820.2 - 6.5 6.8 21.2 0.2 11.7 6.4 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.7 EDK40820.2 - 6.7 7.0 11.9 14 5.9 0.4 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein WXG100 PF06013.7 EDK40820.2 - 7.7 6.6 8.7 8.6 6.4 0.9 2.8 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Flavin_Reduct PF01613.13 EDK40821.1 - 1.8e-26 92.8 0.0 2.3e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Peptidase_C50 PF03568.12 EDK40822.2 - 2.9e-88 296.1 0.0 9.4e-88 294.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase family C50 DUF1833 PF08875.6 EDK40822.2 - 0.017 14.2 0.0 0.055 12.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1833) TPR_8 PF13181.1 EDK40822.2 - 0.034 13.9 0.3 1.9 8.4 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Mpp10 PF04006.7 EDK40823.2 - 2e-95 320.4 63.5 3.5e-95 319.6 44.0 1.4 1 1 0 1 1 1 1 Mpp10 protein DUF1488 PF07369.6 EDK40823.2 - 0.058 13.2 2.7 0.1 12.4 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1488) FtsJ PF01728.14 EDK40824.2 - 8.1e-62 208.4 0.0 9.8e-62 208.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 EDK40824.2 - 1.7e-05 24.4 0.0 0.00088 18.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK40824.2 - 0.0016 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40824.2 - 0.02 15.4 0.0 0.56 10.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain PIR PF00399.14 EDK40825.1 - 9e-13 47.0 93.5 0.031 13.6 2.3 9.9 9 0 0 9 9 9 9 Yeast PIR protein repeat HCV_NS5a_1a PF08300.8 EDK40825.1 - 0.01 15.7 2.0 33 4.4 0.0 5.0 3 1 4 7 7 7 0 Hepatitis C virus non-structural 5a zinc finger domain vWA-TerF-like PF10138.4 EDK40825.1 - 0.011 15.5 8.8 0.049 13.4 0.9 2.5 1 1 1 2 2 2 0 vWA found in TerF C terminus RC-P840_PscD PF10657.4 EDK40825.1 - 0.021 14.6 6.9 0.68 9.7 0.2 3.6 1 1 4 5 5 5 0 Photosystem P840 reaction centre protein PscD Med15 PF09606.5 EDK40825.1 - 0.17 10.0 33.2 0.19 9.9 23.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Copine PF07002.11 EDK40825.1 - 5.5 6.7 17.2 8.3 6.1 0.3 4.3 1 1 4 5 5 5 0 Copine RRN3 PF05327.6 EDK40826.2 - 7.6e-194 644.9 14.2 9.6e-194 644.6 9.9 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Pex16 PF08610.5 EDK40826.2 - 0.003 16.5 4.8 0.27 10.2 0.1 2.8 2 1 0 2 2 2 2 Peroxisomal membrane protein (Pex16) DUF4496 PF14908.1 EDK40826.2 - 0.036 13.9 0.1 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4496) DUF724 PF05266.9 EDK40827.2 - 0.016 14.8 0.1 0.028 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) JAB PF01398.16 EDK40827.2 - 0.078 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF1752 PF08550.5 EDK40829.2 - 1.5e-12 46.8 3.0 2.6e-12 46.0 2.1 1.4 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF3661 PF12400.3 EDK40830.2 - 3.5e-42 143.5 5.8 3.5e-42 143.5 4.0 1.4 2 0 0 2 2 2 1 Vaculolar membrane protein COX17 PF05051.8 EDK40831.1 - 5.8e-22 77.4 8.5 6.4e-22 77.3 5.9 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 EDK40831.1 - 6.3e-05 22.7 5.4 9.4e-05 22.2 3.7 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 EDK40831.1 - 0.0094 15.7 0.1 0.0094 15.7 0.1 2.1 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1903 PF08991.5 EDK40831.1 - 0.28 11.3 6.1 0.75 10.0 4.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1903) Vps54 PF07928.7 EDK40832.2 - 3.6e-35 121.0 2.4 7.3e-35 120.0 0.0 2.8 3 0 0 3 3 3 1 Vps54-like protein FluMu_gp41 PF10109.4 EDK40832.2 - 0.0087 15.9 0.1 0.044 13.7 0.0 2.1 2 0 0 2 2 2 1 Mu-like prophage FluMu protein gp41 DUF2312 PF10073.4 EDK40832.2 - 0.038 13.3 0.1 0.15 11.4 0.1 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) IF-2B PF01008.12 EDK40833.2 - 1.5e-57 194.7 0.1 2.2e-57 194.1 0.1 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family Pex2_Pex12 PF04757.9 EDK40834.2 - 1.4e-57 194.8 13.0 1.7e-57 194.4 9.0 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.1 EDK40834.2 - 1.8e-06 27.6 2.2 3.4e-06 26.8 1.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 EDK40834.2 - 5.6e-06 26.2 2.9 1e-05 25.4 1.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK40834.2 - 0.00064 19.3 0.8 0.0012 18.4 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 EDK40834.2 - 0.0013 18.1 0.2 1.9 7.9 0.1 2.5 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-C3HC4 PF00097.20 EDK40834.2 - 0.002 17.7 2.3 0.0038 16.8 1.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK40834.2 - 0.0036 17.0 2.4 0.0067 16.2 1.7 1.5 1 1 0 1 1 1 1 Ring finger domain Not3 PF04065.10 EDK40835.2 - 1.6e-77 259.9 21.3 2.7e-77 259.1 14.8 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 EDK40835.2 - 8.6e-05 22.4 11.9 0.0019 18.0 0.1 4.2 5 0 0 5 5 5 2 NOT2 / NOT3 / NOT5 family DivIC PF04977.10 EDK40835.2 - 1.1 8.7 9.7 3.8 7.0 1.8 3.3 3 1 0 3 3 3 0 Septum formation initiator DUF904 PF06005.7 EDK40835.2 - 6.1 7.2 13.0 11 6.4 3.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF904) HSP70 PF00012.15 EDK40836.2 - 3.8e-89 299.2 1.7 4.7e-89 298.9 1.2 1.0 1 0 0 1 1 1 1 Hsp70 protein DIOX_N PF14226.1 EDK40836.2 - 0.095 13.2 0.5 0.21 12.1 0.2 1.6 1 1 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal YbaB_DNA_bd PF02575.11 EDK40836.2 - 0.61 9.9 5.4 2.3 8.1 0.5 2.3 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family CotH PF08757.6 EDK40836.2 - 3.6 6.7 7.9 15 4.7 5.0 1.9 1 1 1 2 2 2 0 CotH protein HSP70 PF00012.15 EDK40837.1 - 3.7e-77 259.6 0.7 4.5e-77 259.3 0.5 1.0 1 0 0 1 1 1 1 Hsp70 protein FtsA PF14450.1 EDK40837.1 - 0.01 15.6 0.6 0.029 14.2 0.4 1.8 1 1 0 1 1 1 0 Cell division protein FtsA cNMP_binding PF00027.24 EDK40838.2 - 4.3e-42 141.8 0.4 3e-20 71.8 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.12 EDK40838.2 - 2.4e-09 36.4 0.4 8e-09 34.7 0.2 2.0 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.6 EDK40838.2 - 0.16 11.4 1.6 2.8 7.5 0.4 2.5 2 0 0 2 2 2 0 Cupin domain Abhydrolase_6 PF12697.2 EDK40839.2 - 8.5e-19 68.3 0.0 1.2e-18 67.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK40839.2 - 2.2e-11 43.7 0.1 4.1e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK40839.2 - 3.6e-10 39.7 0.0 5.6e-10 39.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EDK40839.2 - 1.1e-07 31.5 0.0 2.4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DUF2305 PF10230.4 EDK40839.2 - 7.6e-06 25.5 0.2 2.5e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2305) DUF915 PF06028.6 EDK40839.2 - 0.0013 17.8 0.1 0.0034 16.5 0.1 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.8 EDK40839.2 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.20 EDK40839.2 - 0.0015 18.1 0.2 0.0066 16.0 0.1 2.0 1 1 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.9 EDK40839.2 - 0.0039 16.5 0.0 0.0085 15.4 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Thioesterase PF00975.15 EDK40839.2 - 0.021 15.0 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 Thioesterase domain Ser_hydrolase PF06821.8 EDK40839.2 - 0.032 13.8 0.0 0.15 11.6 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase UPF0565 PF10561.4 EDK40839.2 - 0.035 12.9 0.1 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF900 PF05990.7 EDK40839.2 - 0.054 12.8 0.0 0.084 12.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) NAD_synthase PF02540.12 EDK40840.2 - 7.1e-24 84.0 0.0 2.5e-23 82.2 0.0 1.8 1 1 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.17 EDK40840.2 - 1.1e-23 83.5 0.0 1.7e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Asn_synthase PF00733.16 EDK40840.2 - 0.00091 18.7 0.1 0.0018 17.8 0.1 1.4 1 0 0 1 1 1 1 Asparagine synthase TauD PF02668.11 EDK40841.2 - 8.2e-47 160.0 0.0 1.2e-46 159.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 EDK40841.2 - 0.02 15.3 0.1 9.8 6.7 0.0 2.4 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily CBM_X PF06204.6 EDK40841.2 - 0.094 12.2 0.0 1.1 8.8 0.0 2.6 3 0 0 3 3 3 0 Putative carbohydrate binding domain Rib PF08428.5 EDK40841.2 - 0.098 12.4 0.4 0.52 10.1 0.1 2.2 2 0 0 2 2 2 0 Rib/alpha-like repeat Erg28 PF03694.8 EDK40842.1 - 9.7e-46 154.3 0.7 1.1e-45 154.1 0.5 1.0 1 0 0 1 1 1 1 Erg28 like protein HRXXH PF13933.1 EDK40843.2 - 3e-107 357.6 2.3 4.8e-107 356.9 1.6 1.3 1 0 0 1 1 1 1 Putative peptidase family Methyltransf_33 PF10017.4 EDK40843.2 - 0.1 12.5 0.6 0.17 11.7 0.4 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Ssl1 PF04056.9 EDK40844.2 - 3e-66 222.7 0.1 4.5e-66 222.1 0.1 1.3 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 EDK40844.2 - 1.3e-21 76.3 12.1 2.4e-21 75.4 4.3 2.5 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 EDK40844.2 - 3.5e-09 36.9 0.0 6.2e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 EDK40844.2 - 2.8e-05 23.9 0.8 5.1e-05 23.0 0.5 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.16 EDK40844.2 - 0.27 11.1 13.1 0.025 14.4 2.5 2.6 1 1 1 2 2 2 0 IBR domain DZR PF12773.2 EDK40844.2 - 1.1 9.1 17.1 8.6e+02 -0.2 11.8 3.1 1 1 0 1 1 1 0 Double zinc ribbon zf-HIT PF04438.11 EDK40844.2 - 7 6.3 22.5 1.4 8.6 2.9 3.9 4 0 0 4 4 4 0 HIT zinc finger Spt5-NGN PF03439.8 EDK40845.2 - 2.3e-22 78.5 0.0 4.3e-22 77.6 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 EDK40845.2 - 3e-22 79.0 18.4 3e-22 79.0 12.8 3.4 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 EDK40845.2 - 3e-13 48.9 13.6 2.7e-06 26.8 0.2 6.1 6 0 0 6 6 6 3 KOW motif NusG PF02357.14 EDK40845.2 - 0.004 17.3 0.1 0.2 11.9 0.0 3.0 2 0 0 2 2 2 1 Transcription termination factor nusG YajC PF02699.10 EDK40845.2 - 0.21 11.2 5.8 1 9.1 0.3 3.5 3 1 1 4 4 4 0 Preprotein translocase subunit AA_permease PF00324.16 EDK40846.2 - 1.3e-87 294.1 42.4 1.7e-87 293.8 29.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK40846.2 - 1.6e-25 89.5 45.0 2.3e-25 89.0 31.2 1.1 1 0 0 1 1 1 1 Amino acid permease Pribosyltran PF00156.22 EDK40848.2 - 2.1e-16 59.7 0.0 2.6e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EDK40848.2 - 0.0033 16.6 0.0 0.0042 16.3 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_3 PF15610.1 EDK40848.2 - 0.021 13.7 0.0 0.03 13.2 0.0 1.1 1 0 0 1 1 1 0 PRTase ComF-like HD PF01966.17 EDK40849.2 - 2.3e-07 30.8 0.0 3.5e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 HD domain Med13_C PF06333.7 EDK40850.2 - 1.2e-126 422.7 0.3 1.2e-126 422.7 0.2 3.3 3 1 0 3 3 3 1 Mediator complex subunit 13 C-terminal MFS_1 PF07690.11 EDK40851.2 - 2.9e-37 128.2 31.8 2.9e-37 128.2 22.0 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.15 EDK40851.2 - 0.0074 14.3 7.9 0.29 9.1 3.9 2.8 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF1993 PF09351.5 EDK40852.2 - 3.1e-36 124.7 0.0 3.5e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) XFP_N PF09364.5 EDK40852.2 - 0.12 10.9 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 XFP N-terminal domain Apc15p PF05841.6 EDK40853.2 - 0.0018 19.0 8.1 0.039 14.6 3.7 2.6 2 0 0 2 2 2 1 Apc15p protein TSC22 PF01166.13 EDK40853.2 - 0.06 13.3 6.0 3.6 7.6 0.2 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.16 EDK40853.2 - 1.1 9.2 10.3 4.5 7.3 0.1 3.6 2 1 2 4 4 4 0 bZIP transcription factor Ndc1_Nup PF09531.5 EDK40853.2 - 1.8 6.8 4.8 3.5 5.9 3.3 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NYD-SP28_assoc PF14775.1 EDK40853.2 - 8.9 6.1 7.8 1.2 8.9 0.6 2.7 3 0 0 3 3 3 0 Sperm tail C-terminal domain Cyclin_N PF00134.18 EDK40854.2 - 2.5e-43 146.6 1.5 5.9e-42 142.2 0.5 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 EDK40854.2 - 4.5e-33 113.6 0.1 1.4e-32 112.0 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain BRCT PF00533.21 EDK40855.2 - 1.1e-24 86.3 0.1 1.6e-08 34.5 0.0 6.1 5 0 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EDK40855.2 - 6.8e-19 67.4 5.9 5.5e-12 45.3 0.2 5.5 6 1 0 6 6 6 3 twin BRCT domain Wzz PF02706.10 EDK40855.2 - 0.045 13.5 1.1 0.095 12.5 0.8 1.5 1 0 0 1 1 1 0 Chain length determinant protein ENTH PF01417.15 EDK40856.2 - 3.5e-40 136.7 0.0 5.9e-40 136.0 0.0 1.4 1 0 0 1 1 1 1 ENTH domain UIM PF02809.15 EDK40856.2 - 0.0001 21.5 7.5 0.017 14.6 0.5 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif PAT1 PF09770.4 EDK40856.2 - 0.00041 18.7 53.4 0.00053 18.3 37.0 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 EDK40856.2 - 0.017 13.4 64.1 0.022 12.9 44.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.8 EDK40857.2 - 0.022 14.6 15.5 0.014 15.2 4.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 EDK40857.2 - 0.083 10.7 19.1 0.12 10.2 13.2 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2722 PF10846.3 EDK40857.2 - 0.098 11.6 8.7 0.031 13.3 4.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) BSP_II PF05432.6 EDK40857.2 - 0.1 11.8 17.2 0.22 10.7 11.9 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Ycf1 PF05758.7 EDK40857.2 - 0.1 10.2 1.0 0.13 9.9 0.7 1.1 1 0 0 1 1 1 0 Ycf1 CobT PF06213.7 EDK40857.2 - 0.15 11.1 18.7 0.23 10.5 13.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_ner PF04546.8 EDK40857.2 - 0.63 9.6 14.7 1.4 8.4 10.2 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region Daxx PF03344.10 EDK40857.2 - 1.6 7.1 24.8 0.15 10.5 13.9 1.6 2 0 0 2 2 2 0 Daxx Family RNA_pol_3_Rpc31 PF11705.3 EDK40857.2 - 1.6 8.5 20.5 3.5 7.5 14.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.7 EDK40857.2 - 1.9 7.6 17.4 3.2 6.9 12.1 1.3 1 0 0 1 1 1 0 SDA1 RR_TM4-6 PF06459.7 EDK40857.2 - 3.9 7.2 13.8 8.3 6.2 9.6 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.6 EDK40857.2 - 5 6.4 16.5 8.7 5.6 11.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Radial_spoke PF04712.7 EDK40857.2 - 8.3 5.0 18.0 13 4.3 12.5 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein CDC45 PF02724.9 EDK40857.2 - 8.4 4.2 16.7 15 3.4 11.6 1.3 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.10 EDK40857.2 - 8.8 4.8 7.0 13 4.3 4.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Glyco_hydro_76 PF03663.9 EDK40858.2 - 5.3e-151 503.2 17.8 6.3e-151 502.9 12.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 PX PF00787.19 EDK40859.2 - 6.9e-15 54.8 0.8 6.9e-15 54.8 0.6 2.4 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 EDK40859.2 - 7.5e-07 28.6 4.0 1.2e-05 24.7 0.5 2.2 2 0 0 2 2 2 1 Vps5 C terminal like DUF1664 PF07889.7 EDK40859.2 - 0.0026 17.5 1.1 1.3 8.8 0.0 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) DNA_topoisoIV PF00521.15 EDK40859.2 - 0.0078 15.1 1.0 0.0078 15.1 0.7 2.1 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DUF1627 PF07789.7 EDK40859.2 - 0.033 13.7 0.8 5 6.6 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1627) IncA PF04156.9 EDK40859.2 - 0.035 13.7 8.3 0.81 9.2 0.2 2.6 2 1 0 2 2 2 0 IncA protein WD40_alt PF14077.1 EDK40859.2 - 0.08 12.5 0.1 0.25 10.9 0.0 1.8 1 0 0 1 1 1 0 Alternative WD40 repeat motif Tropomyosin_1 PF12718.2 EDK40859.2 - 0.23 11.2 10.5 0.26 11.1 0.3 3.2 4 0 0 4 4 4 0 Tropomyosin like RmuC PF02646.11 EDK40859.2 - 0.27 10.0 5.8 0.059 12.2 0.3 2.3 2 1 0 2 2 2 0 RmuC family BLOC1_2 PF10046.4 EDK40859.2 - 0.65 10.1 6.9 5.3 7.2 0.2 3.3 3 0 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.7 EDK40859.2 - 1.3 9.2 9.0 4.2 7.7 0.4 3.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.3 EDK40859.2 - 2 8.2 11.9 4.5 7.1 1.8 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Nup54 PF13874.1 EDK40859.2 - 2.2 7.9 6.7 1.5 8.4 0.1 2.9 4 0 0 4 4 4 0 Nucleoporin complex subunit 54 SIR2 PF02146.12 EDK40860.2 - 1.6e-56 190.8 0.0 9.9e-56 188.2 0.0 2.0 2 0 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.17 EDK40860.2 - 0.031 14.0 0.0 10 5.9 0.0 2.7 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.8 EDK40860.2 - 0.35 10.4 1.8 4.9 6.7 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF592) Lung_7-TM_R PF06814.8 EDK40861.2 - 7e-59 199.1 16.9 1.4e-58 198.2 11.7 1.5 1 0 0 1 1 1 1 Lung seven transmembrane receptor PCI PF01399.22 EDK40862.2 - 5e-08 33.2 1.6 8e-08 32.5 0.1 2.2 2 1 0 2 2 2 1 PCI domain TBSV_P22 PF03558.8 EDK40862.2 - 0.0057 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 TBSV core protein P21/P22 TPR_19 PF14559.1 EDK40862.2 - 0.043 14.1 0.8 0.41 11.0 0.0 3.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Spc97_Spc98 PF04130.8 EDK40863.1 - 0.0024 16.2 0.4 0.0032 15.8 0.1 1.4 1 1 0 1 1 1 1 Spc97 / Spc98 family PX PF00787.19 EDK40864.2 - 4e-22 78.1 0.0 6.6e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 PX domain Mannosyl_trans3 PF11051.3 EDK40865.2 - 4.7e-88 295.0 0.0 6.5e-88 294.5 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 EDK40865.2 - 0.0071 15.6 0.0 0.018 14.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 TFIIIC_delta PF12657.2 EDK40866.2 - 1.1e-09 38.2 0.1 4e-09 36.4 0.0 2.0 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.2 EDK40866.2 - 5.2e-06 26.2 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex PALP PF00291.20 EDK40868.2 - 8e-57 192.7 0.0 9.1e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Nop53 PF07767.6 EDK40868.2 - 0.14 11.1 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Myco_arth_vir_N PF09610.5 EDK40868.2 - 0.18 11.7 2.4 0.55 10.2 1.6 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Helicase_C_2 PF13307.1 EDK40869.2 - 6.6e-55 185.5 0.0 1.6e-54 184.3 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 EDK40869.2 - 8.8e-48 161.9 1.1 2e-47 160.8 0.8 1.7 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.10 EDK40869.2 - 3.7e-06 26.8 0.1 0.0079 16.0 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK40869.2 - 0.0027 17.2 2.4 0.84 9.1 0.0 2.7 2 1 0 2 2 2 2 DEAD/DEAH box helicase SNF2_N PF00176.18 EDK40869.2 - 0.019 13.8 0.0 0.94 8.2 0.0 2.3 2 0 0 2 2 2 0 SNF2 family N-terminal domain AAA_22 PF13401.1 EDK40869.2 - 0.023 14.8 0.0 1.1 9.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 EDK40869.2 - 0.035 13.3 0.0 6.1 6.0 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein 2OG-FeII_Oxy_3 PF13640.1 EDK40870.2 - 7e-13 48.9 0.0 1.1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 EDK40870.2 - 2e-05 24.1 0.6 7.5e-05 22.2 0.4 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 EDK40870.2 - 0.00037 20.7 0.0 0.00067 19.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UspB PF10625.4 EDK40870.2 - 0.081 12.7 0.1 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) Nic96 PF04097.9 EDK40871.2 - 9e-211 701.2 4.0 1.3e-210 700.6 2.7 1.2 1 0 0 1 1 1 1 Nup93/Nic96 DUF2232 PF09991.4 EDK40871.2 - 0.071 12.0 0.5 0.18 10.7 0.2 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) AA_permease_2 PF13520.1 EDK40872.2 - 4.4e-49 167.1 50.4 5.5e-49 166.8 35.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK40872.2 - 1.7e-25 89.2 44.4 2.1e-25 89.0 30.7 1.0 1 0 0 1 1 1 1 Amino acid permease LNS2 PF08235.8 EDK40873.2 - 1.2e-72 242.6 0.0 1.9e-72 241.9 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 EDK40873.2 - 1.9e-37 127.3 0.1 1e-36 124.9 0.0 2.3 2 0 0 2 2 2 1 lipin, N-terminal conserved region Hydrolase_6 PF13344.1 EDK40873.2 - 0.11 12.4 0.0 0.49 10.3 0.0 2.1 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase SURF2 PF05477.6 EDK40873.2 - 6.5 5.8 18.3 14 4.6 12.7 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) TFIIA PF03153.8 EDK40873.2 - 7.6 6.3 26.7 9.7 5.9 13.8 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SM-ATX PF14438.1 EDK40875.2 - 0.092 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF3589 PF12141.3 EDK40876.2 - 1.3e-185 617.4 0.8 1.5e-185 617.2 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) DUF3589 PF12141.3 EDK40877.2 - 1.4e-201 670.1 0.0 2.1e-201 669.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) RRM_1 PF00076.17 EDK40880.2 - 1.7e-12 46.8 0.4 1.5e-08 34.1 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40880.2 - 7.5e-10 38.5 0.0 6.1e-09 35.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40880.2 - 9.4e-08 31.9 0.1 2.1e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_3 PF07859.8 EDK40881.2 - 1e-11 44.8 0.0 2e-11 43.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK40881.2 - 1.6e-09 37.6 0.0 2.1e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 EDK40881.2 - 8.2e-07 28.4 0.1 5.1e-06 25.8 0.1 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 EDK40881.2 - 7.4e-06 26.0 0.0 4.3e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 EDK40881.2 - 9.5e-05 21.5 1.3 0.00011 21.3 0.2 1.7 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) BAAT_C PF08840.6 EDK40881.2 - 0.00012 21.9 0.2 0.0016 18.1 0.1 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.15 EDK40881.2 - 0.001 18.7 0.0 0.016 14.7 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2424 PF10340.4 EDK40881.2 - 0.0014 17.3 0.0 0.013 14.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2424) DUF2305 PF10230.4 EDK40881.2 - 0.0033 16.8 0.0 0.0062 15.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 EDK40881.2 - 0.0076 15.8 0.0 0.017 14.6 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein DUF900 PF05990.7 EDK40881.2 - 0.018 14.3 0.0 0.036 13.3 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.20 EDK40881.2 - 0.023 14.2 0.0 0.053 13.1 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) LCAT PF02450.10 EDK40881.2 - 0.024 13.6 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase FSH1 PF03959.8 EDK40881.2 - 0.04 13.3 0.0 0.056 12.8 0.0 1.3 1 1 0 1 1 1 0 Serine hydrolase (FSH1) eIF3g PF12353.3 EDK40882.1 - 2.4e-45 153.5 3.7 3.3e-45 153.1 2.6 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 EDK40882.1 - 7.1e-13 47.9 0.0 1.4e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK40882.1 - 4.8e-10 39.2 0.0 1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK40882.1 - 3.5e-05 23.5 0.0 7.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RLL PF10036.4 EDK40882.1 - 0.013 14.9 0.1 0.019 14.4 0.1 1.2 1 0 0 1 1 1 0 Putative carnitine deficiency-associated protein Sua5_yciO_yrdC PF01300.13 EDK40882.1 - 0.1 11.8 0.0 0.44 9.7 0.0 1.9 2 0 0 2 2 2 0 Telomere recombination WD40 PF00400.27 EDK40883.2 - 4.9e-31 105.4 12.3 2.2e-09 36.8 0.0 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ABC2_membrane_3 PF12698.2 EDK40883.2 - 0.16 10.9 0.5 0.74 8.7 0.3 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein STAG PF08514.6 EDK40884.2 - 6.6e-19 67.7 0.2 2.3e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 STAG domain HEAT_2 PF13646.1 EDK40884.2 - 0.00019 21.6 0.0 0.0046 17.2 0.0 3.2 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.17 EDK40884.2 - 0.024 14.7 0.4 2.2 8.6 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat SWIRM PF04433.12 EDK40885.2 - 2.7e-32 110.7 1.1 6.5e-32 109.5 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.26 EDK40885.2 - 9.6e-08 31.9 0.0 2.3e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.12 EDK40885.2 - 9.5e-05 21.8 3.3 0.003 17.0 0.3 2.2 2 0 0 2 2 2 2 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.1 EDK40885.2 - 0.0017 18.4 0.0 0.009 16.0 0.0 2.3 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 EDK40885.2 - 0.014 15.4 0.0 0.07 13.2 0.0 2.2 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Peptidase_C6 PF00851.13 EDK40885.2 - 0.15 10.6 5.8 0.27 9.8 4.0 1.3 1 0 0 1 1 1 0 Helper component proteinase FTR1 PF03239.9 EDK40886.1 - 2.2e-94 315.8 9.9 2.6e-94 315.6 6.8 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3112 PF11309.3 EDK40886.1 - 0.082 12.6 7.1 0.013 15.3 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) DUF4293 PF14126.1 EDK40886.1 - 0.19 11.6 3.6 1.4 8.8 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4293) UPF0154 PF03672.8 EDK40886.1 - 6.3 6.4 6.4 2.3 7.9 0.3 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) FAA_hydrolase PF01557.13 EDK40887.2 - 1.2e-48 165.5 0.0 1.5e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family dCMP_cyt_deam_1 PF00383.17 EDK40888.2 - 9.5e-25 86.2 0.7 1.4e-24 85.6 0.5 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region AAA_18 PF13238.1 EDK40888.2 - 0.00047 20.4 0.1 0.0011 19.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK40888.2 - 0.0064 17.2 0.2 0.021 15.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain Patched PF02460.13 EDK40889.2 - 6.4e-69 232.7 22.1 1e-47 162.5 0.9 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.3 EDK40889.2 - 2.8e-45 153.4 8.9 2.8e-45 153.4 6.2 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 EDK40889.2 - 5.3e-05 22.0 1.8 5.3e-05 22.0 1.2 2.8 2 1 0 2 2 2 1 MMPL family DUF3094 PF11293.3 EDK40889.2 - 3.9 7.0 7.1 2.8 7.4 0.3 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) CBM_48 PF02922.13 EDK40890.2 - 0.011 15.7 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) DNA_RNApol_7kD PF03604.8 EDK40891.1 - 3.2e-15 55.2 2.7 4.3e-15 54.8 1.9 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.14 EDK40891.1 - 0.0003 20.4 0.3 0.00032 20.3 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family FYDLN_acid PF09538.5 EDK40891.1 - 0.0012 19.3 0.2 0.0013 19.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) DZR PF12773.2 EDK40891.1 - 0.0071 16.1 1.3 0.014 15.2 0.9 1.4 1 1 0 1 1 1 1 Double zinc ribbon C1_1 PF00130.17 EDK40891.1 - 0.0077 15.9 0.9 0.01 15.5 0.6 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 EDK40891.1 - 0.012 15.3 0.7 0.019 14.7 0.5 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zn_Tnp_IS1595 PF12760.2 EDK40891.1 - 0.019 14.7 1.3 0.41 10.4 0.1 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain NCD3G PF07562.9 EDK40891.1 - 0.023 14.4 0.3 0.032 13.9 0.2 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR FYVE PF01363.16 EDK40891.1 - 0.026 14.4 1.5 0.033 14.0 1.0 1.2 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.11 EDK40891.1 - 0.027 14.3 0.5 0.03 14.2 0.4 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger TFIIS_C PF01096.13 EDK40891.1 - 0.065 12.8 1.7 1.6 8.4 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-C3HC PF07967.8 EDK40891.1 - 0.074 12.8 0.2 0.077 12.7 0.2 1.2 1 0 0 1 1 1 0 C3HC zinc finger-like A2L_zn_ribbon PF08792.5 EDK40891.1 - 0.1 12.1 1.6 0.45 10.0 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn_ribbon_recom PF13408.1 EDK40891.1 - 0.13 12.5 1.1 0.13 12.5 0.8 1.8 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-ISL3 PF14690.1 EDK40891.1 - 0.14 12.1 0.3 0.14 12.1 0.2 1.6 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 UPF0547 PF10571.4 EDK40891.1 - 0.21 11.3 2.7 0.96 9.2 1.9 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 ZZ PF00569.12 EDK40891.1 - 0.21 11.1 1.9 11 5.6 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, ZZ type Zn-ribbon_8 PF09723.5 EDK40891.1 - 0.45 10.4 4.4 2.6 8.0 3.1 2.1 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_5 PF13719.1 EDK40891.1 - 0.47 10.0 4.6 13 5.4 3.3 2.2 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EDK40891.1 - 0.59 9.8 4.4 15 5.4 3.1 2.2 1 1 0 1 1 1 0 zinc-ribbon domain RRN7 PF11781.3 EDK40891.1 - 1.2 8.6 4.5 10 5.7 0.2 2.3 1 1 1 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 PPR_2 PF13041.1 EDK40892.2 - 0.00051 19.9 0.1 0.0022 17.9 0.1 2.1 1 0 0 1 1 1 1 PPR repeat family WSC PF01822.14 EDK40893.2 - 3.6e-11 42.8 11.4 3.6e-11 42.8 7.9 3.4 2 1 0 2 2 2 1 WSC domain TrbL PF04610.9 EDK40893.2 - 0.094 12.3 0.2 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein TMEM51 PF15345.1 EDK40893.2 - 0.18 11.5 23.9 1.3 8.6 0.2 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 IncA PF04156.9 EDK40893.2 - 2.3 7.7 10.0 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 IncA protein Hid1 PF12722.2 EDK40893.2 - 5.5 4.5 22.5 2.2 5.8 11.5 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein PPI_Ypi1 PF07491.6 EDK40894.2 - 1.6e-28 98.0 6.5 2.9e-28 97.2 4.5 1.5 1 0 0 1 1 1 1 Protein phosphatase inhibitor MFMR PF07777.6 EDK40894.2 - 0.31 10.9 7.3 0.44 10.4 5.0 1.3 1 0 0 1 1 1 0 G-box binding protein MFMR SR-25 PF10500.4 EDK40894.2 - 8.3 5.8 14.5 13 5.1 10.1 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-C2H2 PF00096.21 EDK40895.2 - 1.5e-07 31.2 15.7 9.7e-05 22.4 1.8 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 EDK40895.2 - 5.6e-05 23.2 3.5 5.6e-05 23.2 2.4 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 EDK40895.2 - 0.014 15.7 1.0 0.014 15.7 0.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK40895.2 - 0.015 15.4 0.2 0.043 13.9 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 EDK40895.2 - 0.016 15.4 1.3 0.016 15.4 0.9 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 EDK40895.2 - 0.056 13.7 1.7 0.056 13.7 1.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Wound_ind PF08186.6 EDK40896.1 - 0.0047 16.8 0.1 0.0047 16.8 0.0 1.9 2 0 0 2 2 2 1 Wound-inducible basic protein family tRNA_Me_trans PF03054.11 EDK40897.2 - 5.3e-120 400.2 0.0 6.1e-120 400.0 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.12 EDK40897.2 - 9.1e-07 28.0 0.0 0.00015 20.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Asn_synthase PF00733.16 EDK40897.2 - 2e-05 24.2 0.0 3.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.15 EDK40897.2 - 0.00047 19.6 0.0 0.00097 18.6 0.0 1.5 1 0 0 1 1 1 1 PP-loop family ThiI PF02568.9 EDK40897.2 - 0.0032 16.9 0.0 0.011 15.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.8 EDK40897.2 - 0.0062 15.8 0.1 0.059 12.6 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC DUF4058 PF13267.1 EDK40898.2 - 0.0056 15.8 0.8 0.022 13.8 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4058) Rho_Binding PF08912.6 EDK40898.2 - 0.022 15.0 1.8 3.7 7.9 0.1 2.9 3 0 0 3 3 3 0 Rho Binding CCDC155 PF14662.1 EDK40898.2 - 0.032 13.8 8.7 0.044 13.3 4.8 1.8 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Tn7_Tnp_TnsA_C PF08721.6 EDK40898.2 - 0.2 11.7 1.6 1.5 8.9 0.0 2.8 3 1 0 3 3 3 0 TnsA endonuclease C terminal DUF972 PF06156.8 EDK40898.2 - 0.67 10.3 8.2 8.7 6.7 1.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Kinetocho_Slk19 PF12709.2 EDK40898.2 - 0.68 10.0 6.6 4.2 7.5 0.1 3.4 3 1 0 3 3 3 0 Central kinetochore-associated EMP24_GP25L PF01105.19 EDK40898.2 - 1.9 8.2 5.1 0.66 9.6 0.0 2.3 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Syntaxin PF00804.20 EDK40898.2 - 2.3 8.4 9.6 6.1 7.0 1.3 2.9 1 1 3 4 4 4 0 Syntaxin Syntaxin_2 PF14523.1 EDK40898.2 - 3.6 7.6 9.2 5.4 7.1 1.2 2.5 1 1 1 2 2 2 0 Syntaxin-like protein Fib_alpha PF08702.5 EDK40898.2 - 4.7 7.3 9.3 0.83 9.7 2.5 2.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FlxA PF14282.1 EDK40898.2 - 5.9 6.8 11.5 6 6.8 1.6 3.3 3 1 0 3 3 3 0 FlxA-like protein Pro_isomerase PF00160.16 EDK40899.2 - 8.7e-52 175.4 0.7 1.5e-51 174.6 0.5 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 EDK40899.2 - 0.0013 18.5 0.1 8.4 6.4 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Gmad1 PF10647.4 EDK40899.2 - 0.13 11.6 0.1 4.3 6.6 0.0 3.0 4 0 0 4 4 4 0 Lipoprotein LpqB beta-propeller domain EAF PF09816.4 EDK40900.2 - 4.8e-17 61.9 0.2 1e-16 60.8 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor SNase PF00565.12 EDK40901.1 - 9.2e-21 74.1 0.0 1.2e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue PGM_PMM_I PF02878.11 EDK40902.1 - 1.4e-17 63.4 0.0 2.3e-07 30.3 0.0 2.7 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 EDK40902.1 - 2.5e-15 56.6 0.5 1.3e-13 51.1 0.1 2.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EDK40902.1 - 1.8e-09 37.4 0.3 4.3e-09 36.2 0.2 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.11 EDK40902.1 - 0.0077 16.2 0.1 0.025 14.6 0.1 1.9 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Acetyltransf_5 PF13444.1 EDK40902.1 - 0.056 14.0 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RrnaAD PF00398.15 EDK40904.2 - 6.8e-63 212.1 0.0 9.9e-63 211.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 EDK40904.2 - 2.1e-08 34.1 0.0 4.1e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40904.2 - 0.00012 22.6 0.0 0.00028 21.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 EDK40904.2 - 0.0051 16.1 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 EDK40904.2 - 0.0084 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 EDK40904.2 - 0.0096 15.0 0.0 0.026 13.6 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 EDK40904.2 - 0.032 13.7 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 EDK40904.2 - 0.046 13.4 0.0 0.091 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain KAR9 PF08580.5 EDK40905.2 - 4.4e-36 124.4 14.9 6.4e-36 123.9 10.3 1.2 1 0 0 1 1 1 1 Yeast cortical protein KAR9 TAN PF11640.3 EDK40905.2 - 0.018 14.8 0.7 0.043 13.5 0.5 1.6 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Kelch_3 PF13415.1 EDK40906.2 - 1.4e-40 136.5 1.8 4.8e-10 39.3 0.0 7.3 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.1 EDK40906.2 - 5.9e-36 122.0 8.5 2.4e-07 30.3 0.0 7.1 5 2 1 6 6 6 5 Galactose oxidase, central domain DUF4110 PF13422.1 EDK40906.2 - 7.4e-28 96.2 0.0 7.4e-28 96.2 0.0 4.5 3 2 1 4 4 4 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.1 EDK40906.2 - 2.6e-24 84.3 5.8 1.9e-06 27.7 0.1 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_5 PF13854.1 EDK40906.2 - 1e-20 73.2 1.5 0.0028 17.5 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 EDK40906.2 - 2.6e-16 58.8 7.5 0.00043 19.7 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 EDK40906.2 - 1.8e-11 43.2 12.1 0.056 13.2 0.0 6.7 6 1 0 6 6 6 4 Kelch motif DUF2724 PF10893.3 EDK40906.2 - 0.043 13.6 0.0 0.17 11.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2724) Spore_coat_CotO PF14153.1 EDK40906.2 - 0.17 11.3 32.4 0.04 13.3 4.7 3.1 3 0 0 3 3 3 0 Spore coat protein CotO CAF1C_H4-bd PF12265.3 EDK40908.1 - 9.9e-19 67.0 0.0 2.3e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 EDK40908.1 - 3.1e-17 61.7 17.8 5.4e-07 29.2 0.0 5.3 7 0 0 7 7 7 4 WD domain, G-beta repeat Dabb PF07876.7 EDK40908.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain PRP1_N PF06424.7 EDK40909.2 - 6.1e-34 117.1 0.7 2.3e-33 115.3 0.5 2.1 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 EDK40909.2 - 2.7e-22 77.2 2.2 0.014 15.9 0.0 11.7 9 4 4 13 13 12 4 Tetratricopeptide repeat TPR_19 PF14559.1 EDK40909.2 - 6.5e-19 68.0 0.4 4.2e-05 23.7 0.0 8.6 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.1 EDK40909.2 - 2.6e-16 58.9 0.5 0.00051 19.6 0.0 7.1 5 2 1 6 6 6 4 TPR repeat TPR_17 PF13431.1 EDK40909.2 - 1e-12 47.1 0.2 3.8 7.9 0.0 9.7 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK40909.2 - 2.4e-10 40.8 0.0 0.5 11.0 0.0 7.2 7 1 2 9 9 8 2 Tetratricopeptide repeat TPR_2 PF07719.12 EDK40909.2 - 1.8e-08 33.6 0.4 0.025 14.4 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK40909.2 - 1.2e-06 27.8 0.0 0.4 10.3 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 EDK40909.2 - 1.9e-06 27.1 13.4 0.01 14.9 1.0 4.8 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 EDK40909.2 - 8e-06 25.7 0.1 0.0081 16.0 0.0 4.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK40909.2 - 2.2e-05 24.5 10.3 2 9.0 0.0 7.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_8 PF13181.1 EDK40909.2 - 0.00051 19.6 1.8 4.9 7.1 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat Dynamin_N PF00350.18 EDK40909.2 - 0.033 14.0 0.4 0.13 12.0 0.1 2.1 2 0 0 2 2 2 0 Dynamin family Fer4_13 PF13370.1 EDK40909.2 - 0.074 13.4 0.0 15 6.0 0.0 3.5 3 0 0 3 3 3 0 4Fe-4S single cluster domain Apc3 PF12895.2 EDK40909.2 - 0.11 12.6 4.0 2.6 8.2 0.0 3.5 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MAD PF05557.8 EDK40910.2 - 5.3e-27 94.2 64.9 1e-25 90.0 45.0 2.8 1 1 0 1 1 1 1 Mitotic checkpoint protein bZIP_1 PF00170.16 EDK40910.2 - 0.00021 21.1 3.5 0.0083 16.0 0.3 9.8 8 3 1 10 10 10 3 bZIP transcription factor Reo_sigmaC PF04582.7 EDK40910.2 - 0.004 16.3 3.3 0.004 16.3 2.3 4.4 3 1 1 4 4 4 2 Reovirus sigma C capsid protein Filament PF00038.16 EDK40910.2 - 0.072 12.5 71.3 0.016 14.7 7.8 4.6 1 1 2 4 4 4 0 Intermediate filament protein WD40_alt PF14077.1 EDK40910.2 - 0.25 11.0 7.1 6.7 6.4 0.5 3.7 3 0 0 3 3 3 0 Alternative WD40 repeat motif Tropomyosin_1 PF12718.2 EDK40910.2 - 8.5 6.2 75.2 0.063 13.1 2.6 7.1 3 2 3 6 6 6 0 Tropomyosin like UQ_con PF00179.21 EDK40911.2 - 1.7e-19 69.6 0.1 1.9e-19 69.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 EDK40911.2 - 0.0029 17.5 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 RWD domain Mitochondr_Som1 PF11093.3 EDK40912.2 - 1.7e-37 127.0 1.3 2.5e-37 126.5 0.9 1.3 1 0 0 1 1 1 1 Mitochondrial export protein Som1 MBOAT PF03062.14 EDK40913.2 - 4.5e-54 183.7 26.5 4.5e-54 183.7 18.4 2.2 2 1 1 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family Sec7 PF01369.15 EDK40914.2 - 4.3e-32 111.3 3.7 1.2e-31 109.8 2.6 1.8 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 EDK40914.2 - 0.0042 17.2 1.8 0.0072 16.4 0.0 2.4 3 0 0 3 3 3 1 Pleckstrin homology domain Proteasome PF00227.21 EDK40915.2 - 9.3e-43 145.7 0.0 1.1e-42 145.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF3948 PF13134.1 EDK40915.2 - 0.12 11.8 0.2 0.3 10.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3948) Cmc1 PF08583.5 EDK40916.2 - 1e-16 60.4 8.9 1.9e-16 59.6 6.2 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 EDK40916.2 - 0.15 12.0 2.3 6.4 6.8 0.2 2.4 2 0 0 2 2 2 0 CHCH domain Takusan PF04822.8 EDK40916.2 - 0.29 10.9 7.0 0.43 10.3 4.8 1.3 1 0 0 1 1 1 0 Takusan Peptidase_S10 PF00450.17 EDK40917.2 - 5.9e-132 440.7 0.3 7.9e-132 440.3 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 EDK40917.2 - 7.1e-23 80.9 0.1 1.2e-22 80.2 0.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Abhydrolase_6 PF12697.2 EDK40917.2 - 0.0014 18.5 0.0 0.021 14.7 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family rRNA_proc-arch PF13234.1 EDK40919.2 - 3e-93 311.8 0.8 5.3e-93 311.0 0.6 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 EDK40919.2 - 3.8e-67 225.0 0.5 8e-67 223.9 0.4 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 EDK40919.2 - 9.8e-22 77.2 0.0 4.4e-21 75.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK40919.2 - 3.8e-07 29.8 0.0 1.2e-06 28.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain T2SE PF00437.15 EDK40919.2 - 0.044 12.6 0.0 0.11 11.3 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein Glyco_hydro_20 PF00728.17 EDK40920.2 - 5e-87 292.3 1.6 6.2e-87 292.0 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 EDK40920.2 - 1.2e-17 64.8 0.0 3.8e-17 63.1 0.0 1.9 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 EDK40920.2 - 9.5e-05 22.9 0.0 0.00016 22.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF1624 PF07786.7 EDK40922.2 - 0.00068 19.0 0.8 0.0014 18.0 0.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1624) Sugar_tr PF00083.19 EDK40923.2 - 4.6e-75 252.9 31.0 5.4e-75 252.6 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40923.2 - 5.5e-12 45.0 32.4 7.3e-12 44.6 21.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily PITH PF06201.8 EDK40924.2 - 9.5e-39 132.5 0.0 1.2e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 PITH domain Nodulin_late PF07127.6 EDK40925.2 - 5.4 7.2 6.4 5.7 7.1 1.3 2.5 2 0 0 2 2 2 0 Late nodulin protein His_Phos_1 PF00300.17 EDK40926.1 - 2.7e-41 141.2 0.0 3.8e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Nucleoporin_FG PF13634.1 EDK40927.2 - 0.013 15.6 30.5 0.021 15.0 21.2 1.3 1 0 0 1 1 1 0 Nucleoporin FG repeat region Period_C PF12114.3 EDK40927.2 - 4.3 6.9 8.4 5.9 6.4 5.8 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Macoilin PF09726.4 EDK40927.2 - 6.4 4.9 7.0 7.2 4.7 4.8 1.0 1 0 0 1 1 1 0 Transmembrane protein TAP42 PF04177.7 EDK40928.2 - 0.1 11.5 5.7 0.12 11.2 4.0 1.3 1 0 0 1 1 1 0 TAP42-like family Nsp1_C PF05064.8 EDK40930.2 - 5.3e-32 109.9 5.5 5.3e-32 109.9 3.8 2.0 3 1 0 3 3 3 1 Nsp1-like C-terminal region WEMBL PF05701.6 EDK40930.2 - 0.043 12.2 2.2 0.064 11.7 1.6 1.4 1 1 0 1 1 1 0 Weak chloroplast movement under blue light AAA_13 PF13166.1 EDK40930.2 - 0.054 11.9 1.1 0.078 11.4 0.4 1.4 1 1 0 1 1 1 0 AAA domain Bul1_C PF04426.7 EDK40930.2 - 0.12 11.5 1.8 0.13 11.4 0.2 1.8 2 0 0 2 2 2 0 Bul1 C terminus NPV_P10 PF05531.7 EDK40930.2 - 0.28 11.4 6.1 0.3 11.3 0.1 3.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein PMC2NT PF08066.7 EDK40930.2 - 0.58 10.4 2.9 0.94 9.8 0.6 2.2 2 1 0 2 2 2 0 PMC2NT (NUC016) domain CorA PF01544.13 EDK40930.2 - 0.63 9.0 4.5 1.2 8.1 0.7 2.4 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein APG6 PF04111.7 EDK40930.2 - 0.65 8.9 6.4 0.18 10.8 2.1 1.7 1 1 1 2 2 2 0 Autophagy protein Apg6 Cor1 PF04803.7 EDK40930.2 - 1.1 8.9 6.0 18 5.0 0.0 3.0 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region PQ-loop PF04193.9 EDK40931.2 - 2.2e-19 68.7 2.3 1.8e-11 43.3 0.0 3.3 2 1 0 2 2 2 2 PQ loop repeat ALAD PF00490.16 EDK40932.2 - 3.9e-114 380.8 0.0 4.4e-114 380.7 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Snf7 PF03357.16 EDK40933.2 - 1.9e-32 112.0 13.2 3.1e-32 111.3 9.2 1.3 1 0 0 1 1 1 1 Snf7 Coiled-coil_56 PF09813.4 EDK40933.2 - 0.13 12.2 2.2 0.6 10.1 1.5 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF1040 PF06288.8 EDK40933.2 - 0.74 10.0 3.5 0.51 10.6 0.3 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1040) GrpE PF01025.14 EDK40933.2 - 2.3 7.7 11.8 0.11 12.0 2.2 2.2 2 0 0 2 2 2 0 GrpE WD40 PF00400.27 EDK40934.2 - 1.1e-18 66.3 16.9 0.00012 21.7 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 EDK40934.2 - 0.0011 18.7 0.7 2.2 7.9 0.0 3.1 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Pkinase PF00069.20 EDK40935.1 - 1.1e-71 241.1 0.0 1.3e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK40935.1 - 5.2e-31 107.6 0.0 7.8e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK40935.1 - 2.5e-05 23.3 0.0 0.0021 17.0 0.0 2.3 1 1 0 2 2 2 2 Kinase-like Kdo PF06293.9 EDK40935.1 - 0.00025 20.1 0.2 0.0022 17.1 0.1 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK40935.1 - 0.00041 20.1 0.1 0.002 17.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 EDK40935.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Rgp1 PF08737.5 EDK40936.2 - 1.3e-112 376.9 0.0 2e-112 376.3 0.0 1.3 1 0 0 1 1 1 1 Rgp1 CBF PF03914.12 EDK40936.2 - 0.039 13.4 0.6 0.075 12.4 0.4 1.4 1 0 0 1 1 1 0 CBF/Mak21 family DUF1034 PF06280.7 EDK40936.2 - 0.065 13.6 0.9 0.15 12.4 0.3 1.8 2 0 0 2 2 2 0 Fn3-like domain (DUF1034) A_deaminase PF00962.17 EDK40937.2 - 1.3e-113 379.2 0.1 2e-113 378.6 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Phos_pyr_kin PF08543.7 EDK40938.2 - 6.8e-65 218.6 0.0 1.2e-64 217.8 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 EDK40938.2 - 7.6e-43 146.7 0.8 1.6e-42 145.6 0.4 1.6 2 0 0 2 2 2 1 TENA/THI-4/PQQC family PfkB PF00294.19 EDK40938.2 - 0.0018 17.4 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.10 EDK40938.2 - 0.034 13.3 0.1 0.17 11.0 0.1 1.9 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family YlaC PF10777.4 EDK40938.2 - 0.064 12.8 0.1 0.14 11.6 0.1 1.5 1 0 0 1 1 1 0 Inner membrane protein YlaC EF-hand_4 PF12763.2 EDK40939.2 - 2.8e-23 81.6 0.0 1.9e-14 53.2 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.6 EDK40939.2 - 4.6e-11 42.6 207.8 1.7e-05 24.8 28.5 9.9 4 2 3 7 7 7 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.27 EDK40939.2 - 2.1e-07 29.7 0.2 0.0061 15.7 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 EDK40939.2 - 6.1e-06 26.2 0.0 0.0046 17.0 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair WH2 PF02205.15 EDK40939.2 - 0.00019 20.9 0.3 0.00052 19.5 0.2 1.7 1 0 0 1 1 1 1 WH2 motif EF-hand_8 PF13833.1 EDK40939.2 - 0.0029 17.1 0.0 0.2 11.2 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 EDK40939.2 - 0.054 13.4 5.4 0.61 10.1 0.0 3.9 5 0 0 5 5 5 0 EF-hand domain AAA_2 PF07724.9 EDK40940.2 - 4.5e-51 173.1 0.5 1.6e-49 168.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 EDK40940.2 - 7.1e-24 83.5 1.6 2.1e-23 82.0 0.6 2.3 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 EDK40940.2 - 3.4e-20 72.6 0.1 1.7e-10 41.1 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EDK40940.2 - 1.3e-17 63.8 0.1 3.6e-11 42.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EDK40940.2 - 6.5e-15 55.5 5.7 3.3e-05 23.9 0.0 4.5 3 2 0 5 5 4 3 AAA ATPase domain AAA_22 PF13401.1 EDK40940.2 - 7e-12 45.6 0.7 8.2e-06 25.9 0.1 3.8 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.21 EDK40940.2 - 4.5e-08 32.7 0.1 3.9e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.1 EDK40940.2 - 1.5e-07 31.3 1.2 0.035 14.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 EDK40940.2 - 7.1e-06 25.5 0.1 0.039 13.3 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 EDK40940.2 - 9.8e-06 25.4 12.5 0.093 12.4 0.1 4.6 3 2 1 4 4 4 2 Archaeal ATPase OmpH PF03938.9 EDK40940.2 - 1.3e-05 25.1 2.7 2.1e-05 24.5 1.2 1.8 2 0 0 2 2 1 1 Outer membrane protein (OmpH-like) NACHT PF05729.7 EDK40940.2 - 1.6e-05 24.6 0.8 0.12 12.0 0.0 3.4 4 0 0 4 4 3 2 NACHT domain AAA_19 PF13245.1 EDK40940.2 - 3e-05 23.6 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain TrwB_AAD_bind PF10412.4 EDK40940.2 - 5.4e-05 21.9 0.4 0.1 11.2 0.1 3.0 2 1 1 3 3 3 2 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.1 EDK40940.2 - 6.2e-05 23.0 2.9 0.68 9.8 0.0 4.3 4 1 0 4 4 3 2 AAA domain RNA_helicase PF00910.17 EDK40940.2 - 7.5e-05 22.8 0.7 0.61 10.2 0.0 3.3 3 1 0 3 3 2 2 RNA helicase AAA_30 PF13604.1 EDK40940.2 - 8.6e-05 22.2 1.2 0.22 11.0 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_17 PF13207.1 EDK40940.2 - 0.00012 22.8 5.3 0.068 13.9 0.0 3.9 3 1 0 3 3 2 1 AAA domain DUF815 PF05673.8 EDK40940.2 - 0.0002 20.3 1.1 0.027 13.3 0.3 3.6 2 2 0 2 2 2 1 Protein of unknown function (DUF815) MobB PF03205.9 EDK40940.2 - 0.00026 20.7 0.1 0.18 11.5 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 EDK40940.2 - 0.00027 20.0 0.0 0.013 14.5 0.0 3.0 2 1 0 2 2 2 1 Zeta toxin DUF87 PF01935.12 EDK40940.2 - 0.00041 20.2 5.5 0.35 10.6 0.0 3.5 3 0 0 3 3 3 1 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 EDK40940.2 - 0.00079 19.3 0.0 0.032 14.1 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.1 EDK40940.2 - 0.0011 19.2 6.5 0.34 11.1 0.0 3.3 3 0 0 3 3 2 2 AAA domain PhoH PF02562.11 EDK40940.2 - 0.0012 18.1 0.0 0.98 8.6 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein T2SE PF00437.15 EDK40940.2 - 0.0013 17.7 0.4 0.13 11.1 0.1 2.6 2 1 0 2 2 2 1 Type II/IV secretion system protein Mg_chelatase PF01078.16 EDK40940.2 - 0.0025 17.0 0.1 1.7 7.7 0.0 3.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI Torsin PF06309.6 EDK40940.2 - 0.0044 16.8 0.0 0.093 12.6 0.0 2.4 2 0 0 2 2 2 1 Torsin ResIII PF04851.10 EDK40940.2 - 0.0086 15.9 6.4 0.81 9.4 0.3 3.6 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit UPF0079 PF02367.12 EDK40940.2 - 0.0086 15.6 0.0 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 EDK40940.2 - 0.0087 15.4 0.1 7.2 5.9 0.0 3.0 2 1 1 3 3 3 0 AAA domain PduV-EutP PF10662.4 EDK40940.2 - 0.013 14.9 0.0 1.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 EDK40940.2 - 0.014 14.8 2.7 2.4 7.4 0.1 3.1 3 1 0 3 3 2 0 AAA-like domain AAA_24 PF13479.1 EDK40940.2 - 0.014 14.9 0.2 3.4 7.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.17 EDK40940.2 - 0.018 14.4 1.5 2 7.7 0.0 3.2 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Malic_M PF03949.10 EDK40940.2 - 0.032 13.7 0.1 0.073 12.6 0.1 1.5 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain DUF2075 PF09848.4 EDK40940.2 - 0.044 12.7 0.0 0.044 12.7 0.0 2.6 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.1 EDK40940.2 - 0.048 13.5 0.1 5.2 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 EDK40940.2 - 0.066 12.3 0.1 12 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Seryl_tRNA_N PF02403.17 EDK40940.2 - 0.072 13.1 10.8 0.11 12.5 5.6 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_3 PF07726.6 EDK40940.2 - 0.075 12.6 0.1 1.5 8.4 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 EDK40940.2 - 0.18 12.1 6.1 0.9 9.8 0.0 3.5 3 2 0 3 3 2 0 ABC transporter Miro PF08477.8 EDK40940.2 - 0.22 12.0 2.1 2.3 8.7 0.1 3.1 3 0 0 3 3 3 0 Miro-like protein AAA_15 PF13175.1 EDK40940.2 - 0.25 10.3 5.7 0.46 9.4 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain APG6 PF04111.7 EDK40940.2 - 0.25 10.3 9.2 0.44 9.5 6.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DivIC PF04977.10 EDK40940.2 - 1.6 8.2 14.0 2.9 7.4 4.3 2.9 1 1 1 2 2 2 0 Septum formation initiator V_ATPase_I PF01496.14 EDK40940.2 - 8.5 4.0 6.9 13 3.5 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PalH PF08733.5 EDK40941.2 - 9.9e-98 327.1 10.1 1.2e-97 326.9 7.0 1.0 1 0 0 1 1 1 1 PalH/RIM21 YukC PF10140.4 EDK40941.2 - 0.16 10.5 0.1 2.8 6.4 0.0 2.1 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC Sec23_trunk PF04811.10 EDK40942.2 - 4.1e-43 147.5 0.0 7.1e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EDK40942.2 - 1.7e-24 85.1 0.9 3.5e-24 84.2 0.3 1.8 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EDK40942.2 - 4.4e-17 62.3 0.0 9.1e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EDK40942.2 - 3.8e-12 45.5 8.8 3.8e-12 45.5 6.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EDK40942.2 - 0.099 12.3 0.0 0.29 10.8 0.0 1.8 1 0 0 1 1 1 0 Gelsolin repeat UNC45-central PF11701.3 EDK40943.2 - 4.1e-30 104.4 0.3 4.1e-30 104.4 0.2 4.1 3 2 0 3 3 3 1 Myosin-binding striated muscle assembly central Arm PF00514.18 EDK40943.2 - 0.028 14.2 1.6 10 6.1 0.1 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF3095 PF11294.3 EDK40943.2 - 0.046 12.7 0.0 0.097 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) IU_nuc_hydro PF01156.14 EDK40943.2 - 0.077 12.1 0.0 13 4.9 0.0 2.6 2 0 0 2 2 2 0 Inosine-uridine preferring nucleoside hydrolase ING PF12998.2 EDK40944.1 - 3.3e-24 85.1 6.8 5e-24 84.5 4.7 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 EDK40944.1 - 7e-10 38.4 8.2 1.1e-09 37.7 5.7 1.3 1 0 0 1 1 1 1 PHD-finger Flagellar_rod PF05149.7 EDK40944.1 - 0.011 14.9 3.9 0.016 14.4 2.7 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein zf-HC5HC2H PF13771.1 EDK40944.1 - 0.019 15.1 1.9 0.025 14.7 0.2 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain PHD_2 PF13831.1 EDK40944.1 - 0.084 12.2 3.2 0.15 11.3 2.2 1.5 1 0 0 1 1 1 0 PHD-finger GAPT PF11770.3 EDK40944.1 - 0.12 12.0 0.2 0.55 9.8 0.0 2.0 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) zf-RING-like PF08746.6 EDK40944.1 - 0.25 11.3 2.9 0.44 10.5 2.0 1.4 1 0 0 1 1 1 0 RING-like domain DASH_Spc34 PF08657.5 EDK40944.1 - 3.9 7.0 9.6 0.99 9.0 3.7 1.8 2 0 0 2 2 2 0 DASH complex subunit Spc34 Mgr1 PF08602.5 EDK40946.2 - 1.5e-71 241.3 7.9 1.2e-39 136.3 1.4 2.9 1 1 1 2 2 2 2 Mgr1-like, i-AAA protease complex subunit bZIP_1 PF00170.16 EDK40947.2 - 5.7e-08 32.5 11.2 2.4e-07 30.6 7.8 1.9 1 1 0 1 1 1 1 bZIP transcription factor Tup_N PF08581.5 EDK40947.2 - 0.0045 17.1 2.2 0.011 15.9 1.5 1.6 1 0 0 1 1 1 1 Tup N-terminal Glutaredoxin2_C PF04399.8 EDK40947.2 - 0.014 14.9 0.9 0.023 14.2 0.6 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain TSC22 PF01166.13 EDK40947.2 - 0.056 13.4 0.3 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family CASP_C PF08172.7 EDK40947.2 - 0.11 11.5 3.9 0.21 10.5 2.8 1.5 1 1 0 1 1 1 0 CASP C terminal bZIP_2 PF07716.10 EDK40947.2 - 0.47 10.3 13.5 1.1 9.0 0.9 2.3 1 1 1 2 2 2 0 Basic region leucine zipper Atg14 PF10186.4 EDK40947.2 - 0.54 9.1 10.8 0.7 8.7 7.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_GP20 PF06810.6 EDK40947.2 - 0.67 9.3 9.8 0.69 9.3 5.7 1.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 Nop53 PF07767.6 EDK40947.2 - 0.69 8.8 10.7 0.96 8.3 7.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PEPcase_2 PF14010.1 EDK40947.2 - 0.75 8.0 3.8 1.1 7.5 2.6 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Seryl_tRNA_N PF02403.17 EDK40947.2 - 2.1 8.3 8.9 5.1 7.1 6.1 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain bZIP_Maf PF03131.12 EDK40947.2 - 5.9 7.2 11.4 0.86 9.9 4.2 2.0 2 0 0 2 2 2 0 bZIP Maf transcription factor UPF0449 PF15136.1 EDK40947.2 - 6.7 6.9 9.1 1 9.5 3.6 1.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Spermine_synth PF01564.12 EDK40949.2 - 4.8e-98 326.9 0.1 1.1e-97 325.8 0.0 1.5 2 0 0 2 2 2 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 EDK40949.2 - 0.00092 18.8 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK40949.2 - 0.0021 18.4 0.0 0.0059 17.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK40949.2 - 0.033 14.7 0.0 0.06 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF43 PF01861.11 EDK40949.2 - 0.061 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF43 Methyltransf_30 PF05430.6 EDK40949.2 - 0.097 12.3 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 EDK40949.2 - 0.098 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain MFS_1 PF07690.11 EDK40950.2 - 4.4e-31 107.8 39.0 4.4e-31 107.8 27.0 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Neurensin PF14927.1 EDK40950.2 - 2.8 7.3 6.3 11 5.3 0.0 3.6 3 1 1 4 4 4 0 Neurensin MFS_1 PF07690.11 EDK40951.2 - 8.5e-16 57.6 22.9 1.1e-15 57.1 15.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK40952.2 - 1.7e-15 56.6 22.3 1.7e-15 56.6 15.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Cdd1 PF11731.3 EDK40952.2 - 0.038 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Pathogenicity locus MFS_1_like PF12832.2 EDK40952.2 - 0.077 12.8 4.9 0.037 13.8 1.0 2.5 3 0 0 3 3 3 0 MFS_1 like family PBP PF01161.15 EDK40953.2 - 9.3e-10 38.5 0.2 1.9e-09 37.5 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MIF4G PF02854.14 EDK40954.2 - 1.6e-17 63.6 16.5 1.1e-08 34.8 0.6 3.9 4 1 0 4 4 4 3 MIF4G domain Daxx PF03344.10 EDK40954.2 - 0.48 8.8 33.5 0.98 7.8 23.2 1.4 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 EDK40954.2 - 0.53 8.1 39.0 1.6 6.5 27.0 1.8 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 EDK40954.2 - 4.3 6.3 36.6 8.2 5.3 25.4 1.4 1 0 0 1 1 1 0 BUD22 ATP-synt_E PF05680.7 EDK40955.2 - 7.4e-21 73.9 0.3 1.1e-20 73.4 0.2 1.1 1 0 0 1 1 1 1 ATP synthase E chain SpoIIE PF07228.7 EDK40956.2 - 1.7e-24 86.6 0.0 2.7e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 EDK40956.2 - 2.9e-08 33.3 0.0 5.3e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 EDK40956.2 - 3.2e-07 30.0 0.0 8e-06 25.4 0.0 2.2 1 1 0 2 2 2 1 Protein phosphatase 2C FYVE PF01363.16 EDK40957.2 - 8.2e-19 67.2 24.3 5.7e-17 61.3 2.3 3.1 3 0 0 3 3 3 2 FYVE zinc finger zf-AN1 PF01428.11 EDK40957.2 - 0.017 14.9 10.8 0.017 14.9 7.5 3.8 4 0 0 4 4 4 0 AN1-like Zinc finger Sugar_tr PF00083.19 EDK40958.2 - 4.5e-108 361.7 24.5 5.2e-108 361.5 17.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK40958.2 - 5.5e-20 71.3 25.3 5.5e-20 71.3 17.5 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily CDC45 PF02724.9 EDK40960.2 - 5e-208 692.1 0.4 5.8e-208 691.8 0.3 1.0 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.7 EDK40960.2 - 1.5 6.6 9.9 2.1 6.1 6.9 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2415 PF10313.4 EDK40961.2 - 1.1e-20 72.9 0.2 2.5e-20 71.8 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) DLH PF01738.13 EDK40963.2 - 1.2e-20 73.6 0.0 1.4e-20 73.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EDK40963.2 - 0.0009 19.0 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family TetR_C_7 PF14246.1 EDK40963.2 - 0.0058 16.8 0.0 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal region Ish1 PF10281.4 EDK40963.2 - 0.033 14.2 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein DLH PF01738.13 EDK40964.1 - 6.2e-18 64.8 0.0 7.5e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 EDK40964.1 - 0.00054 19.7 0.0 0.00072 19.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK40964.1 - 0.1 12.4 0.0 0.42 10.4 0.0 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family Exo_endo_phos PF03372.18 EDK40965.2 - 1.7e-16 60.9 0.0 2.3e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4405 PF14358.1 EDK40965.2 - 0.058 13.5 5.3 0.34 11.0 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Spindle_Spc25 PF08234.7 EDK40966.2 - 9.3e-20 70.4 0.4 2.2e-19 69.1 0.3 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 TelA PF05816.6 EDK40966.2 - 2.7 6.6 26.6 0.16 10.6 12.9 2.2 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) DUF2470 PF10615.4 EDK40967.1 - 2.1e-12 47.0 0.0 3.1e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) adh_short PF00106.20 EDK40968.2 - 7.6e-06 25.9 0.0 0.0065 16.3 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 EDK40968.2 - 0.16 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 KR domain WD40 PF00400.27 EDK40972.2 - 2.6e-10 39.7 14.3 0.0013 18.5 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat TFIID_30kDa PF03540.8 EDK40973.2 - 6.5e-28 96.3 0.0 1.1e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Orbi_VP6 PF01516.11 EDK40973.2 - 0.57 9.1 3.9 0.66 8.9 0.3 2.1 1 1 1 2 2 2 0 Orbivirus helicase VP6 MFS_1 PF07690.11 EDK40974.1 - 3.5e-35 121.3 19.8 3.5e-35 121.3 13.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily HECT PF00632.20 EDK40975.2 - 8.6e-88 294.5 0.0 2.4e-87 293.0 0.0 1.8 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) F-actin_cap_A PF01267.12 EDK40976.2 - 6e-72 241.9 4.8 6.8e-72 241.7 3.3 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit SRA1 PF07304.6 EDK40977.2 - 0.0083 15.8 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) PHA_synth_III_E PF09712.5 EDK40977.2 - 0.018 14.4 0.4 0.021 14.2 0.3 1.0 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) PilJ PF13675.1 EDK40977.2 - 0.061 13.6 0.1 0.072 13.4 0.1 1.1 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Lectin_N PF03954.9 EDK40977.2 - 0.086 12.2 0.3 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain IFT57 PF10498.4 EDK40977.2 - 0.093 11.4 0.5 0.11 11.2 0.4 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1359 PF07097.6 EDK40977.2 - 0.1 12.6 0.6 0.13 12.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) SNARE PF05739.14 EDK40977.2 - 0.1 12.3 1.9 0.14 11.8 1.1 1.5 1 1 0 1 1 1 0 SNARE domain Nup54 PF13874.1 EDK40977.2 - 0.45 10.1 2.1 1.4 8.5 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 VHS PF00790.14 EDK40978.2 - 1.1e-32 112.5 1.0 2.4e-32 111.4 0.7 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.23 EDK40978.2 - 1.5e-14 53.0 0.0 2.7e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 EDK40978.2 - 2.5e-14 52.5 0.1 4.6e-14 51.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 EDK40978.2 - 7.7e-12 44.5 0.0 1.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.15 EDK40978.2 - 0.0011 18.4 2.2 0.0046 16.4 1.5 2.2 1 0 0 1 1 1 1 Ubiquitin interaction motif DUF3774 PF12609.3 EDK40978.2 - 0.8 10.6 4.5 0.97 10.3 0.1 3.0 3 0 0 3 3 3 0 Wound-induced protein TRAM_LAG1_CLN8 PF03798.11 EDK40979.1 - 6.8e-34 117.1 22.1 6.8e-34 117.1 15.3 2.2 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 EDK40979.1 - 1.2e-22 79.1 0.5 1.2e-22 79.1 0.3 2.5 2 0 0 2 2 2 1 TRAM1-like protein Ribosomal_S2 PF00318.15 EDK40981.2 - 1.6e-58 197.3 0.0 1.5e-57 194.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S2 Methyltrn_RNA_4 PF09936.4 EDK40981.2 - 0.02 14.4 0.2 0.04 13.4 0.1 1.4 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase AcetDehyd-dimer PF09290.6 EDK40981.2 - 0.063 13.1 0.1 5.4 6.9 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation DUF87 PF01935.12 EDK40981.2 - 0.07 12.9 4.0 0.12 12.1 2.8 1.5 1 1 0 1 1 1 0 Domain of unknown function DUF87 CS PF04969.11 EDK40982.2 - 2.7e-07 31.0 1.5 4.6e-07 30.2 1.0 1.3 1 0 0 1 1 1 1 CS domain Med15 PF09606.5 EDK40982.2 - 0.0059 14.8 1.3 0.0078 14.4 0.9 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Ydc2-catalyt PF09159.5 EDK40982.2 - 0.64 9.4 3.7 0.8 9.1 2.6 1.1 1 0 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF2763 PF10961.3 EDK40982.2 - 1.3 9.4 10.4 0.16 12.4 3.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) Syja_N PF02383.13 EDK40984.2 - 5.4e-93 311.2 3.8 5.4e-93 311.2 2.7 3.1 3 1 1 4 4 4 1 SacI homology domain DUF1863 PF08937.6 EDK40984.2 - 0.78 9.7 8.5 0.12 12.4 1.9 2.4 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) ATP-sulfurylase PF01747.12 EDK40985.2 - 5.3e-81 271.0 0.0 7.1e-81 270.6 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 EDK40985.2 - 5.8e-53 178.5 0.0 1e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain CTP_transf_2 PF01467.21 EDK40985.2 - 0.12 12.3 0.3 1.1 9.3 0.1 2.3 2 1 1 3 3 3 0 Cytidylyltransferase 6PGD PF00393.14 EDK40986.2 - 2.6e-135 450.2 0.0 3.1e-135 450.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 EDK40986.2 - 9.5e-14 51.5 0.0 1.6e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 EDK40986.2 - 0.029 14.4 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase p450 PF00067.17 EDK40987.2 - 2.2e-49 168.2 0.0 2.8e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2636 PF11120.3 EDK40987.2 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2636) CBF PF03914.12 EDK40988.2 - 5e-40 136.6 0.0 1.2e-39 135.3 0.0 1.7 1 0 0 1 1 1 1 CBF/Mak21 family NOC3p PF07540.6 EDK40988.2 - 3.4e-32 110.5 0.2 1.2e-31 108.8 0.2 2.0 1 0 0 1 1 1 1 Nucleolar complex-associated protein SPRY PF00622.23 EDK40989.2 - 6.8e-10 39.0 0.1 1.6e-09 37.8 0.0 1.7 2 0 0 2 2 2 1 SPRY domain TSGP1 PF07771.6 EDK40989.2 - 1.2 9.0 9.0 7.6 6.4 5.1 2.3 2 0 0 2 2 2 0 Tick salivary peptide group 1 Med15 PF09606.5 EDK40990.2 - 0.0004 18.7 49.6 0.00042 18.6 34.4 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 EDK40990.2 - 0.017 13.4 51.9 0.02 13.1 36.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AT_hook PF02178.14 EDK40990.2 - 0.6 9.9 14.9 0.43 10.4 2.4 2.7 2 0 0 2 2 2 0 AT hook motif NpwBP PF12622.2 EDK40990.2 - 0.62 10.5 8.1 21 5.6 5.6 3.2 1 1 0 1 1 1 0 mRNA biogenesis factor TFIIA PF03153.8 EDK40990.2 - 1.4 8.7 31.4 2 8.2 21.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Biotin_lipoyl PF00364.17 EDK40991.2 - 6.4e-19 67.3 0.5 1.1e-18 66.6 0.3 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 EDK40991.2 - 7.5e-05 22.2 0.1 0.00037 20.0 0.0 2.2 3 0 0 3 3 3 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 EDK40991.2 - 0.00029 20.4 0.1 0.011 15.3 0.0 2.9 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_2 PF12700.2 EDK40991.2 - 0.37 9.8 13.9 17 4.4 9.6 2.3 1 1 0 1 1 1 0 HlyD family secretion protein Rtf2 PF04641.7 EDK40991.2 - 0.88 8.7 10.6 1.5 7.9 7.3 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger APC_CDC26 PF10471.4 EDK40991.2 - 3.1 8.6 14.3 0.74 10.6 7.3 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 Nramp PF01566.13 EDK40992.2 - 5.1e-91 305.1 4.5 1e-90 304.1 3.1 1.4 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein Vma12 PF11712.3 EDK40992.2 - 0.0085 15.8 5.8 0.61 9.7 0.0 3.2 3 1 0 3 3 3 2 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1352 PF07086.7 EDK40992.2 - 0.094 12.3 1.3 0.25 10.9 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1352) Shisa PF13908.1 EDK40992.2 - 0.22 11.6 4.2 0.38 10.9 0.0 3.1 3 1 1 4 4 4 0 Wnt and FGF inhibitory regulator Abhydrolase_6 PF12697.2 EDK40993.2 - 7.2e-22 78.3 0.0 9.7e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK40993.2 - 2.5e-18 66.2 0.0 1.1e-16 60.8 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1100 PF06500.6 EDK40993.2 - 3.7e-10 38.9 0.0 5.6e-09 35.0 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1100) AXE1 PF05448.7 EDK40993.2 - 8.4e-10 37.6 0.0 6.1e-06 24.9 0.0 3.0 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.13 EDK40993.2 - 1.3e-08 34.5 0.0 1.6e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.13 EDK40993.2 - 3.1e-08 33.1 0.0 9.1e-05 21.8 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.16 EDK40993.2 - 6.5e-07 28.7 0.0 3e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.6 EDK40993.2 - 4.6e-06 26.4 0.0 0.0042 16.8 0.0 2.1 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 EDK40993.2 - 5.9e-05 22.8 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 EDK40993.2 - 0.0057 16.2 0.0 0.019 14.5 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 EDK40993.2 - 0.051 13.1 0.0 11 5.5 0.0 2.7 3 0 0 3 3 3 0 Serine hydrolase PAF-AH_p_II PF03403.8 EDK40993.2 - 0.13 10.5 0.0 3.4 5.8 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II SRP9-21 PF05486.7 EDK40994.2 - 3.9e-26 90.5 1.2 6e-26 90.0 0.9 1.3 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Di19_C PF14571.1 EDK40994.2 - 7.3 6.9 10.9 5.7 7.3 3.6 2.5 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal CBM_20 PF00686.14 EDK40995.2 - 0.011 15.2 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 Starch binding domain Eclosion PF04736.7 EDK40996.2 - 0.099 12.0 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 Eclosion hormone PMT PF02366.13 EDK40998.2 - 1.5e-76 257.0 16.5 1.5e-76 257.0 11.5 2.6 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EDK40998.2 - 3.7e-55 186.4 0.0 8.7e-55 185.2 0.0 1.7 1 0 0 1 1 1 1 MIR domain HAD_2 PF13419.1 EDK40999.1 - 2.4e-14 53.9 0.0 3e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK40999.1 - 2.4e-05 24.8 0.0 0.00011 22.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 EDK40999.1 - 0.056 13.3 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EDK40999.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Pex2_Pex12 PF04757.9 EDK41000.2 - 5.1e-37 127.4 11.2 7e-37 127.0 7.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_5 PF14634.1 EDK41000.2 - 0.0003 20.4 5.4 0.00074 19.1 3.7 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK41000.2 - 0.00088 19.2 2.0 0.00088 19.2 1.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK41000.2 - 0.0047 16.5 4.3 0.0097 15.5 3.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK41000.2 - 0.017 14.9 2.0 0.017 14.9 1.4 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 EDK41000.2 - 0.047 13.5 5.8 0.4 10.5 4.0 2.1 1 1 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 EDK41000.2 - 0.053 13.2 1.7 0.14 11.8 1.2 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.2 EDK41000.2 - 0.13 12.3 1.5 0.25 11.4 1.0 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger FYVE PF01363.16 EDK41000.2 - 0.85 9.5 4.5 2.8 7.8 3.1 1.9 1 1 0 1 1 1 0 FYVE zinc finger CPL PF08144.6 EDK41001.2 - 1.4e-12 47.7 0.9 1.4e-11 44.4 0.0 3.1 4 1 1 5 5 5 1 CPL (NUC119) domain PUF PF00806.14 EDK41001.2 - 0.00047 19.4 0.9 8.9 6.0 0.0 4.9 4 0 0 4 4 4 1 Pumilio-family RNA binding repeat DUF4253 PF14062.1 EDK41001.2 - 0.038 13.6 0.0 0.091 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) Daxx PF03344.10 EDK41001.2 - 0.2 10.1 31.4 0.29 9.5 21.8 1.2 1 0 0 1 1 1 0 Daxx Family CENP-T PF15511.1 EDK41001.2 - 5.6 6.0 31.5 8.6 5.4 21.8 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Thioredoxin PF00085.15 EDK41002.1 - 4.4e-27 93.7 0.0 5.3e-27 93.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.11 EDK41002.1 - 1.5e-05 23.8 0.0 1.8e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 Phosducin Thioredoxin_2 PF13098.1 EDK41002.1 - 1.6e-05 25.0 0.1 0.00076 19.6 0.1 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 EDK41002.1 - 2.2e-05 24.0 0.0 2.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK41002.1 - 2.4e-05 24.3 0.0 0.00047 20.2 0.0 2.3 1 1 0 1 1 1 1 Thioredoxin-like HyaE PF07449.6 EDK41002.1 - 0.028 14.3 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.1 EDK41002.1 - 0.035 14.1 0.1 0.066 13.2 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like DbpA PF03880.10 EDK41002.1 - 0.071 12.7 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 DbpA RNA binding domain TraF PF13728.1 EDK41002.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Redoxin PF08534.5 EDK41002.1 - 0.16 11.4 0.3 0.44 10.0 0.1 1.7 1 1 1 2 2 2 0 Redoxin AAA PF00004.24 EDK41003.2 - 2.8e-40 137.5 0.0 4.9e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41003.2 - 6.5e-07 29.5 0.2 0.0022 18.1 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.9 EDK41003.2 - 8.9e-06 25.7 0.0 2.5e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EDK41003.2 - 2.6e-05 23.2 0.0 4.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 EDK41003.2 - 0.00016 21.7 0.1 0.0007 19.6 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 EDK41003.2 - 0.00017 21.3 0.1 0.00072 19.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 EDK41003.2 - 0.0011 18.1 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 EDK41003.2 - 0.0013 18.6 0.1 0.0038 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 EDK41003.2 - 0.0036 17.1 0.0 0.0073 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 EDK41003.2 - 0.0049 17.6 0.2 0.016 16.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 EDK41003.2 - 0.0081 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 EDK41003.2 - 0.01 15.6 0.6 0.022 14.5 0.4 1.5 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 EDK41003.2 - 0.01 14.9 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 EDK41003.2 - 0.013 14.8 1.1 0.25 10.7 0.3 2.3 1 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 EDK41003.2 - 0.014 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 EDK41003.2 - 0.015 14.8 0.0 0.033 13.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 EDK41003.2 - 0.021 15.1 0.0 0.053 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 EDK41003.2 - 0.025 13.3 0.0 0.055 12.1 0.0 1.5 1 0 0 1 1 1 0 TIP49 C-terminus NB-ARC PF00931.17 EDK41003.2 - 0.031 13.1 0.0 0.056 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 EDK41003.2 - 0.038 14.1 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase KaiC PF06745.8 EDK41003.2 - 0.038 13.1 0.1 0.53 9.3 0.1 2.2 1 1 1 2 2 2 0 KaiC NACHT PF05729.7 EDK41003.2 - 0.051 13.2 0.1 0.39 10.3 0.0 2.2 1 1 0 2 2 2 0 NACHT domain NTPase_1 PF03266.10 EDK41003.2 - 0.054 13.1 0.1 0.32 10.6 0.0 2.4 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.16 EDK41003.2 - 0.06 12.5 0.1 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 EDK41003.2 - 0.072 12.6 0.2 0.17 11.4 0.2 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EDK41003.2 - 0.082 12.1 0.4 0.24 10.6 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein Bax1-I PF01027.15 EDK41004.1 - 8.1e-49 166.0 30.9 9.3e-49 165.8 21.4 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2215 PF10225.4 EDK41004.1 - 0.42 10.0 15.9 0.34 10.3 9.6 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2215) Fst_toxin PF13955.1 EDK41004.1 - 0.94 9.2 6.8 1.5 8.5 1.6 2.6 2 0 0 2 2 2 0 Toxin Fst, type I toxin-antitoxin system zf-RING_2 PF13639.1 EDK41005.2 - 7.3e-12 44.9 6.6 1.1e-11 44.3 4.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK41005.2 - 9.8e-11 41.5 5.8 1.6e-10 40.8 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK41005.2 - 3.9e-10 39.2 5.3 6.4e-10 38.5 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 EDK41005.2 - 1.1e-09 37.7 5.4 1.8e-09 37.1 3.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 EDK41005.2 - 2.1e-08 33.8 4.3 5.6e-08 32.5 3.0 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EDK41005.2 - 4.7e-07 29.4 1.8 4.7e-07 29.4 1.3 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 EDK41005.2 - 7.7e-07 28.7 6.6 1.6e-06 27.7 4.6 1.6 1 1 0 1 1 1 1 zinc-RING finger domain FANCL_C PF11793.3 EDK41005.2 - 0.0033 17.3 4.3 0.015 15.2 3.0 1.9 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_4 PF14570.1 EDK41005.2 - 0.0045 16.5 3.5 0.02 14.4 2.5 2.1 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain TerY-C PF15616.1 EDK41005.2 - 0.0055 16.6 4.9 0.038 13.9 3.4 2.0 1 1 0 1 1 1 1 TerY-C metal binding domain zf-rbx1 PF12678.2 EDK41005.2 - 0.015 15.3 3.7 0.034 14.2 2.6 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger zf-MIZ PF02891.15 EDK41005.2 - 0.018 14.5 6.8 0.045 13.2 4.7 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Rtf2 PF04641.7 EDK41005.2 - 0.035 13.2 0.2 0.043 13.0 0.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1644 PF07800.7 EDK41005.2 - 0.048 13.5 2.2 1.9 8.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) zf-Apc11 PF12861.2 EDK41005.2 - 0.065 13.0 2.8 0.24 11.2 1.9 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FYVE PF01363.16 EDK41005.2 - 0.14 12.0 5.4 0.34 10.8 3.7 1.7 1 1 0 1 1 1 0 FYVE zinc finger UPF0547 PF10571.4 EDK41005.2 - 0.82 9.4 7.6 42 3.9 0.0 3.1 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 IBR PF01485.16 EDK41005.2 - 1.6 8.6 5.4 0.99 9.3 1.9 2.1 1 1 0 1 1 1 0 IBR domain Prok-RING_4 PF14447.1 EDK41005.2 - 2.1 7.9 11.2 15 5.2 5.1 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 EDK41005.2 - 4.1 7.2 5.9 28 4.6 4.1 2.3 1 1 0 1 1 1 0 zf-RING of BARD1-type protein PH PF00169.24 EDK41006.2 - 3e-13 49.8 0.6 6.5e-13 48.7 0.4 1.6 1 0 0 1 1 1 1 PH domain SOBP PF15279.1 EDK41006.2 - 0.13 12.6 17.1 0.26 11.6 11.8 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein Ribosomal_L14 PF00238.14 EDK41007.1 - 1.3e-31 108.8 0.0 1.5e-31 108.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e WSC PF01822.14 EDK41008.2 - 1.2e-11 44.3 17.2 1.2e-11 44.3 12.0 3.0 2 1 0 2 2 2 1 WSC domain Mitofilin PF09731.4 EDK41008.2 - 0.0066 15.1 3.9 0.008 14.8 2.7 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Herpes_UL32 PF06070.6 EDK41008.2 - 0.1 11.0 21.4 0.13 10.6 14.8 1.1 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 SKG6 PF08693.5 EDK41008.2 - 0.33 10.2 1.4 2 7.8 1.0 2.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ABC2_membrane_3 PF12698.2 EDK41008.2 - 1.2 8.1 4.0 1.7 7.5 2.8 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF605 PF04652.11 EDK41008.2 - 2.2 7.6 28.3 0.034 13.5 14.8 1.5 2 0 0 2 2 2 0 Vta1 like Podoplanin PF05808.6 EDK41008.2 - 6.7 6.2 29.9 0.023 14.2 10.1 2.4 1 1 1 2 2 2 0 Podoplanin DUF572 PF04502.8 EDK41008.2 - 9.4 5.3 18.2 19 4.3 12.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF572) Epimerase PF01370.16 EDK41009.2 - 1.9e-20 73.2 0.0 2.5e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK41009.2 - 5.5e-11 41.6 0.0 7.4e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 EDK41009.2 - 6e-11 41.7 0.0 6.1e-09 35.1 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EDK41009.2 - 8.3e-11 42.2 0.1 1.8e-10 41.1 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 EDK41009.2 - 0.00027 20.8 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 EDK41009.2 - 0.0036 16.5 0.1 0.016 14.4 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.15 EDK41009.2 - 0.02 14.8 0.1 0.042 13.7 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Use1 PF09753.4 EDK41010.2 - 5.9e-10 39.0 0.1 8e-10 38.5 0.1 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 ERG2_Sigma1R PF04622.7 EDK41010.2 - 0.085 12.0 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein Erp_C PF06780.6 EDK41010.2 - 0.89 9.3 3.4 0.58 9.9 0.4 2.0 2 0 0 2 2 2 0 Erp protein C-terminus RRM_6 PF14259.1 EDK41011.2 - 2.7e-31 107.3 0.1 6.3e-08 32.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 EDK41011.2 - 6.2e-27 93.0 0.4 4.5e-08 32.6 0.2 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK41011.2 - 1.2e-22 79.5 0.6 1.3e-06 28.1 0.1 4.7 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 EDK41011.2 - 0.0051 16.5 0.1 0.16 11.7 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 EDK41011.2 - 0.19 11.5 0.1 0.53 10.1 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif COX4 PF02936.9 EDK41013.1 - 3.5e-38 130.5 0.1 4.4e-38 130.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Pkinase PF00069.20 EDK41014.2 - 1e-41 142.8 0.0 1.9e-41 141.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41014.2 - 3.9e-24 85.1 0.0 7.9e-24 84.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase GATA PF00320.22 EDK41015.2 - 1.4e-32 110.7 17.8 7.5e-17 60.3 4.2 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 EDK41015.2 - 8.4e-07 28.2 5.9 0.0044 16.3 0.3 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding RRN7 PF11781.3 EDK41015.2 - 6.7e-06 25.4 4.2 0.035 13.6 0.4 2.5 2 0 0 2 2 2 2 RNA polymerase I-specific transcription initiation factor Rrn7 ArfGap PF01412.13 EDK41015.2 - 0.00025 20.7 2.2 0.072 12.8 0.1 2.3 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf Zn-ribbon_8 PF09723.5 EDK41015.2 - 0.0072 16.2 2.5 1.8 8.5 0.0 2.8 3 0 0 3 3 3 2 Zinc ribbon domain Auto_anti-p27 PF06677.7 EDK41015.2 - 0.025 14.3 3.8 0.67 9.7 0.4 2.8 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.6 EDK41015.2 - 0.035 13.7 0.3 0.035 13.7 0.2 2.8 3 0 0 3 3 3 0 Putative transposase DNA-binding domain DZR PF12773.2 EDK41015.2 - 0.038 13.8 12.2 0.14 11.9 0.1 3.0 2 1 0 2 2 2 0 Double zinc ribbon zf-RING_3 PF14369.1 EDK41015.2 - 0.075 13.0 0.3 0.075 13.0 0.2 2.7 2 0 0 2 2 2 0 zinc-finger eIF-5_eIF-2B PF01873.12 EDK41015.2 - 0.39 10.3 4.0 10 5.7 0.3 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Eapp_C PF10238.4 EDK41015.2 - 0.49 10.2 4.9 0.23 11.3 0.4 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein zf-ribbon_3 PF13248.1 EDK41015.2 - 4 6.7 14.0 8.6 5.7 1.9 3.2 2 2 0 2 2 2 0 zinc-ribbon domain zf-Sec23_Sec24 PF04810.10 EDK41015.2 - 7.3 6.2 15.1 0.34 10.5 0.6 3.3 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Mito_carr PF00153.22 EDK41016.1 - 8.9e-54 179.1 2.4 1.2e-17 63.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fer4 PF00037.22 EDK41017.2 - 8.1e-14 50.5 16.9 3.3e-08 32.7 2.8 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 EDK41017.2 - 9e-13 48.2 34.3 5.7e-09 36.1 8.1 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_7 PF12838.2 EDK41017.2 - 3.7e-12 46.4 10.7 7.2e-12 45.4 7.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 EDK41017.2 - 1.9e-10 40.3 24.0 2.4e-08 33.6 8.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.1 EDK41017.2 - 7e-10 39.5 10.5 3.2e-05 24.6 1.0 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.1 EDK41017.2 - 2e-09 37.3 4.7 5.1e-05 23.2 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 EDK41017.2 - 2.9e-08 33.4 33.0 1.8e-05 24.4 8.9 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.2 EDK41017.2 - 1.1e-07 31.3 14.5 0.00042 20.0 1.5 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 EDK41017.2 - 1.9e-07 31.3 6.7 0.0018 18.5 1.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 EDK41017.2 - 4.2e-07 29.7 12.8 0.0006 19.9 2.1 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.2 EDK41017.2 - 5.8e-07 29.1 17.4 0.0013 18.5 3.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.1 EDK41017.2 - 6.7e-05 23.2 11.1 0.017 15.5 0.6 2.6 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_15 PF13459.1 EDK41017.2 - 0.0052 17.3 12.8 0.27 11.8 1.3 2.9 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_13 PF13370.1 EDK41017.2 - 0.0088 16.4 15.7 0.31 11.4 3.2 2.9 2 1 1 3 3 3 2 4Fe-4S single cluster domain Fer4_3 PF12798.2 EDK41017.2 - 0.016 15.7 17.5 0.042 14.4 2.8 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 EDK41017.2 - 0.097 12.8 6.0 0.31 11.2 0.1 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain DSPc PF00782.15 EDK41019.2 - 1.3e-25 89.4 0.0 3.6e-24 84.8 0.0 2.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.7 EDK41019.2 - 7.6e-05 21.7 0.4 0.0003 19.7 0.0 1.9 1 1 1 2 2 2 1 Initiator tRNA phosphoribosyl transferase Y_phosphatase PF00102.22 EDK41019.2 - 0.00014 21.2 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 EDK41019.2 - 0.058 13.4 0.0 0.18 11.8 0.0 1.8 1 1 0 1 1 1 0 Inositol hexakisphosphate Ank_2 PF12796.2 EDK41020.2 - 1.7e-32 111.5 1.2 7.7e-13 48.5 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 EDK41020.2 - 4e-27 92.6 4.9 3.9e-10 39.0 0.1 6.4 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.1 EDK41020.2 - 3.3e-25 87.5 1.7 9.4e-08 32.0 0.1 5.3 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK41020.2 - 3e-23 79.5 1.8 8.1e-07 28.6 0.1 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.1 EDK41020.2 - 1.9e-22 79.1 0.6 2.1e-07 31.2 0.0 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) DUF2011 PF09428.5 EDK41021.1 - 6.5e-27 93.9 19.6 6.5e-27 93.9 13.6 1.4 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2011) COG5 PF10392.4 EDK41022.2 - 3.5e-37 127.3 0.1 7.9e-37 126.1 0.1 1.6 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Sec23_trunk PF04811.10 EDK41023.2 - 1.3e-65 221.1 0.0 1.9e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 EDK41023.2 - 6.8e-25 86.4 0.0 1.7e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 EDK41023.2 - 1.9e-17 63.5 0.0 5.6e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 EDK41023.2 - 2.3e-16 59.0 8.0 4e-16 58.2 5.5 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 EDK41023.2 - 0.0011 18.6 0.0 0.0039 16.8 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat DUF4336 PF14234.1 EDK41024.2 - 0.05 12.7 0.6 5.8 6.0 0.0 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4336) Epimerase PF01370.16 EDK41025.2 - 1.2e-23 83.7 0.2 2.1e-23 82.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK41025.2 - 8.8e-23 80.3 0.1 1.1e-22 80.0 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK41025.2 - 5.3e-19 68.9 0.1 7.8e-19 68.3 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK41025.2 - 5.4e-19 68.1 0.1 1e-18 67.1 0.1 1.4 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EDK41025.2 - 1.7e-09 37.3 0.0 2.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 EDK41025.2 - 1.7e-05 24.6 0.1 3.2e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 EDK41025.2 - 5.4e-05 23.1 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 EDK41025.2 - 0.00078 18.4 0.1 0.0015 17.4 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF2639 PF11121.3 EDK41025.2 - 0.024 14.1 0.0 0.064 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) Abhydrolase_6 PF12697.2 EDK41026.2 - 6.9e-37 127.5 0.0 7.9e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41026.2 - 2.7e-25 89.2 0.0 4.3e-25 88.6 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK41026.2 - 6e-23 81.2 1.1 2.9e-21 75.7 0.8 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 EDK41026.2 - 3e-12 46.2 0.1 7.4e-12 44.9 0.1 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Peptidase_S9 PF00326.16 EDK41026.2 - 1.2e-08 34.4 0.3 0.0021 17.3 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.13 EDK41026.2 - 9.5e-05 21.7 0.0 0.0088 15.3 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF915 PF06028.6 EDK41026.2 - 0.0032 16.5 0.1 0.017 14.2 0.0 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_2 PF02230.11 EDK41026.2 - 0.0072 15.7 0.1 0.016 14.6 0.0 1.5 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DUF1749 PF08538.5 EDK41026.2 - 0.024 13.5 0.0 0.24 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Ser_hydrolase PF06821.8 EDK41026.2 - 0.075 12.6 0.0 0.61 9.6 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase PAF-AH_p_II PF03403.8 EDK41026.2 - 0.087 11.0 0.1 2.7 6.2 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.6 EDK41026.2 - 0.092 11.5 0.0 0.19 10.4 0.0 1.5 1 1 0 1 1 1 0 Chlorophyllase Ndr PF03096.9 EDK41026.2 - 0.11 10.9 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family ADH_zinc_N PF00107.21 EDK41027.2 - 6.3e-14 51.6 0.2 1.1e-13 50.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK41027.2 - 6e-07 29.2 0.7 1.3e-05 24.9 0.4 2.8 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 EDK41027.2 - 0.098 13.5 0.0 0.2 12.5 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 4HBT PF03061.17 EDK41028.1 - 2.2e-08 34.0 0.0 4e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Asn_synthase PF00733.16 EDK41029.2 - 6.9e-46 156.8 0.0 9.9e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 EDK41029.2 - 4.5e-10 39.3 0.1 1.3e-08 34.5 0.0 3.0 3 1 0 3 3 3 1 Glutamine amidotransferase domain GATase_6 PF13522.1 EDK41029.2 - 3.6e-06 26.9 0.0 1.2e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase domain CReP_N PF10472.4 EDK41029.2 - 0.0031 16.2 0.0 0.0053 15.5 0.0 1.2 1 0 0 1 1 1 1 eIF2-alpha phosphatase phosphorylation constitutive repressor Glutaredoxin PF00462.19 EDK41030.2 - 0.064 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin Pkinase PF00069.20 EDK41031.2 - 2.2e-25 89.3 0.1 4.2e-25 88.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41031.2 - 6.1e-14 51.7 0.0 1.5e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase ParcG PF10274.4 EDK41031.2 - 0.0023 17.8 0.5 0.005 16.7 0.1 1.7 2 0 0 2 2 2 1 Parkin co-regulated protein RRM_1 PF00076.17 EDK41032.2 - 6.2e-13 48.1 0.0 9.4e-13 47.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK41032.2 - 2.8e-11 43.2 0.0 4.7e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK41032.2 - 1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gtr1_RagA PF04670.7 EDK41033.2 - 2.6e-95 318.0 5.2 3.5e-95 317.5 3.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 EDK41033.2 - 2.5e-08 33.4 0.1 5.3e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Ras family Arf PF00025.16 EDK41033.2 - 3.3e-08 32.9 0.6 5.4e-08 32.2 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family Miro PF08477.8 EDK41033.2 - 4.4e-07 30.4 1.8 5.6e-07 30.0 0.1 2.0 2 1 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 EDK41033.2 - 3.5e-06 26.9 0.1 1.1e-05 25.3 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 EDK41033.2 - 0.011 16.0 0.7 0.027 14.7 0.1 2.1 2 1 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 EDK41033.2 - 0.013 15.0 0.3 0.03 13.8 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.8 EDK41033.2 - 0.015 14.2 0.0 0.027 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Cor1 PF04803.7 EDK41033.2 - 0.42 10.3 7.6 4.7 6.9 0.5 3.2 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region SQS_PSY PF00494.14 EDK41034.2 - 5.7e-44 150.4 0.0 7.2e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Cnd1 PF12717.2 EDK41034.2 - 0.011 15.5 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Arg_repressor PF01316.16 EDK41034.2 - 0.03 13.8 0.3 0.078 12.5 0.2 1.7 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF544 PF04424.8 EDK41035.2 - 9.1e-10 38.4 0.0 1.8e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF544) N1221 PF07923.8 EDK41035.2 - 0.032 13.0 0.1 0.066 12.0 0.1 1.5 1 0 0 1 1 1 0 N1221-like protein Paf1 PF03985.8 EDK41036.2 - 1.6e-100 336.9 13.1 1.8e-100 336.7 9.1 1.0 1 0 0 1 1 1 1 Paf1 Hemocyanin_N PF03722.9 EDK41036.2 - 0.1 12.7 0.7 6.6 6.9 0.0 3.1 2 1 1 3 3 3 0 Hemocyanin, all-alpha domain Cupin_8 PF13621.1 EDK41036.2 - 0.28 10.6 3.7 0.6 9.5 0.2 2.2 2 0 0 2 2 2 0 Cupin-like domain FMN_red PF03358.10 EDK41037.2 - 9.3e-13 47.9 0.0 1.2e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 EDK41037.2 - 3.8e-05 23.3 0.0 4.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.20 EDK41037.2 - 0.00087 19.3 0.3 0.0061 16.5 0.2 2.4 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.2 EDK41037.2 - 0.015 15.3 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain Aldo_ket_red PF00248.16 EDK41038.2 - 8.9e-32 110.0 0.0 1.2e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1672 PF07901.6 EDK41038.2 - 0.1 11.5 0.3 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Ras PF00071.17 EDK41039.2 - 9.5e-52 174.6 0.4 1.2e-51 174.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK41039.2 - 6.8e-21 74.9 0.0 1.1e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK41039.2 - 7.9e-16 57.7 0.1 1e-15 57.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 EDK41039.2 - 2e-08 33.6 0.2 2.4e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 EDK41039.2 - 1e-07 31.6 0.2 2.1e-06 27.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK41039.2 - 2.6e-06 27.3 0.0 4.1e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 EDK41039.2 - 4.5e-05 22.7 0.2 6.5e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 EDK41039.2 - 0.00013 21.5 0.3 0.016 14.8 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 EDK41039.2 - 0.00017 21.7 0.0 0.00062 19.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 EDK41039.2 - 0.00031 20.2 0.4 0.007 15.8 0.0 2.3 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arch_ATPase PF01637.13 EDK41039.2 - 0.00032 20.4 0.1 0.00053 19.7 0.1 1.7 1 1 0 1 1 1 1 Archaeal ATPase AAA_24 PF13479.1 EDK41039.2 - 0.0017 17.9 0.1 0.0023 17.5 0.1 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 EDK41039.2 - 0.0024 17.5 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DUF258 PF03193.11 EDK41039.2 - 0.0035 16.5 0.1 0.0099 15.0 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 EDK41039.2 - 0.0036 17.3 0.0 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 EDK41039.2 - 0.0049 16.6 0.4 0.083 12.6 0.3 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Septin PF00735.13 EDK41039.2 - 0.011 14.7 0.3 0.026 13.5 0.1 1.7 2 0 0 2 2 2 0 Septin MobB PF03205.9 EDK41039.2 - 0.012 15.3 0.0 0.025 14.2 0.0 1.6 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 EDK41039.2 - 0.012 15.3 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.17 EDK41039.2 - 0.017 13.9 0.1 0.027 13.3 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_10 PF12846.2 EDK41039.2 - 0.023 14.1 0.1 0.045 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_14 PF13173.1 EDK41039.2 - 0.04 13.8 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain PRK PF00485.13 EDK41039.2 - 0.044 13.3 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.20 EDK41039.2 - 0.049 13.1 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 EDK41039.2 - 0.055 12.9 0.3 0.15 11.5 0.1 1.8 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.17 EDK41039.2 - 0.067 13.3 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA PF00004.24 EDK41039.2 - 0.1 12.8 0.0 0.24 11.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.15 EDK41039.2 - 0.12 11.0 4.1 0.71 8.4 2.8 2.3 1 1 0 1 1 1 0 G-protein alpha subunit ABC_tran PF00005.22 EDK41039.2 - 0.13 12.5 1.6 0.24 11.7 1.1 1.8 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 EDK41039.2 - 0.48 10.7 4.7 1.5 9.0 3.2 1.9 1 1 0 1 1 1 0 AAA domain DUF1771 PF08590.5 EDK41040.2 - 1.1e-23 83.0 12.6 1.1e-23 83.0 8.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.16 EDK41040.2 - 9.5e-16 57.7 0.1 2.7e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Smr domain Seryl_tRNA_N PF02403.17 EDK41040.2 - 0.00037 20.4 1.8 0.0008 19.3 1.3 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Scaffolding_pro PF11418.3 EDK41040.2 - 0.045 14.0 0.3 0.097 13.0 0.2 1.5 1 0 0 1 1 1 0 Phi29 scaffolding protein DUF4407 PF14362.1 EDK41040.2 - 0.88 8.4 4.5 1.3 7.8 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sugar_tr PF00083.19 EDK41041.2 - 8.4e-84 281.7 25.7 1e-83 281.4 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41041.2 - 2.7e-23 82.2 62.7 6.1e-21 74.5 24.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM192 PF14802.1 EDK41041.2 - 0.2 10.5 0.0 0.46 9.2 0.0 1.5 1 0 0 1 1 1 0 TMEM192 family DHDPS PF00701.17 EDK41042.2 - 2.6e-38 131.2 0.0 3e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans PF04082.13 EDK41043.2 - 6.4e-18 64.5 2.0 1e-17 63.8 1.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41043.2 - 3.1e-06 26.9 9.6 7.9e-06 25.6 6.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.1 EDK41043.2 - 0.0057 15.9 2.0 0.011 15.0 1.4 1.4 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain DUF1399 PF07173.7 EDK41044.2 - 3.1e-32 111.7 0.7 3.3e-29 101.9 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF1399) DUF1399 PF07173.7 EDK41045.2 - 6.8e-30 104.1 0.1 2.1e-26 92.8 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1399) GTP_EFTU_D3 PF03143.12 EDK41046.1 - 1.4e-37 127.8 0.1 3.4e-37 126.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.22 EDK41046.1 - 1.1e-19 70.6 0.0 2e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 EDK41046.1 - 5.2e-16 58.5 3.1 5.2e-16 58.5 2.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 EDK41046.1 - 0.001 18.6 1.2 0.001 18.6 0.8 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 BRCT PF00533.21 EDK41047.2 - 2.6e-34 117.1 10.8 9.3e-12 44.9 0.3 5.4 4 1 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 EDK41047.2 - 1.7e-22 79.0 8.0 1.9e-07 30.8 0.1 5.5 5 0 0 5 5 5 5 twin BRCT domain DUF4136 PF13590.1 EDK41047.2 - 0.006 16.6 0.3 0.011 15.8 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4136) PBP1_TM PF14812.1 EDK41047.2 - 0.4 11.0 5.8 0.3 11.4 0.1 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribophorin_I PF04597.9 EDK41048.1 - 0.026 13.0 0.2 0.032 12.7 0.1 1.1 1 0 0 1 1 1 0 Ribophorin I Furin-like PF00757.15 EDK41048.1 - 0.042 13.5 3.5 0.053 13.1 2.5 1.1 1 0 0 1 1 1 0 Furin-like cysteine rich region PLU-1 PF08429.6 EDK41049.2 - 1.6e-40 139.0 4.3 3.8e-40 137.7 0.9 2.8 3 0 0 3 3 3 1 PLU-1-like protein JmjC PF02373.17 EDK41049.2 - 2.8e-14 53.3 0.1 6.2e-07 29.6 0.0 3.0 2 0 0 2 2 2 2 JmjC domain, hydroxylase ARID PF01388.16 EDK41049.2 - 3.1e-13 49.3 1.8 9.7e-13 47.7 0.0 2.9 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain PHD PF00628.24 EDK41049.2 - 4.1e-10 39.1 8.9 9.7e-10 37.9 6.1 1.7 1 0 0 1 1 1 1 PHD-finger AA_permease_2 PF13520.1 EDK41051.2 - 1.1e-61 208.7 48.2 1.3e-61 208.4 33.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK41051.2 - 2.2e-16 59.3 38.3 2.9e-16 58.8 26.6 1.1 1 0 0 1 1 1 1 Amino acid permease US2 PF02476.10 EDK41051.2 - 0.074 13.5 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 US2 family Peptidase_S10 PF00450.17 EDK41052.2 - 7.8e-126 420.5 0.1 1.2e-125 419.9 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 EDK41052.2 - 0.0096 15.8 0.0 0.048 13.5 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Rtf2 PF04641.7 EDK41054.2 - 1e-56 192.0 5.1 1.3e-56 191.7 3.5 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 EDK41054.2 - 0.0078 15.7 0.0 0.083 12.4 0.0 2.5 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit HNH PF01844.18 EDK41054.2 - 0.013 15.3 2.3 0.54 10.1 0.1 2.5 2 0 0 2 2 2 0 HNH endonuclease ADK_lid PF05191.9 EDK41054.2 - 0.029 14.0 0.1 0.089 12.4 0.1 1.9 1 0 0 1 1 1 0 Adenylate kinase, active site lid zf-RING_UBOX PF13445.1 EDK41054.2 - 0.032 13.9 0.3 0.14 11.9 0.0 2.4 2 1 0 2 2 2 0 RING-type zinc-finger zf-C2HC_2 PF13913.1 EDK41054.2 - 0.044 13.4 1.4 0.044 13.4 0.9 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Mss51 PF13824.1 EDK41054.2 - 0.11 12.4 0.4 0.29 11.0 0.3 1.8 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 FYDLN_acid PF09538.5 EDK41054.2 - 0.24 12.0 4.4 0.23 12.0 1.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Rad50_zn_hook PF04423.9 EDK41054.2 - 0.29 10.6 3.6 2.7 7.5 0.1 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif Prefoldin PF02996.12 EDK41055.2 - 7e-25 87.0 0.9 8.6e-25 86.7 0.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit DivIC PF04977.10 EDK41055.2 - 0.14 11.6 1.8 1.1 8.7 0.3 2.2 2 0 0 2 2 2 0 Septum formation initiator Imm31 PF15595.1 EDK41055.2 - 0.14 11.9 0.5 1.1 9.0 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 31 P16-Arc PF04699.9 EDK41055.2 - 0.21 11.5 1.7 0.21 11.5 0.2 1.6 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) ALIX_LYPXL_bnd PF13949.1 EDK41055.2 - 0.24 10.3 4.0 1.7 7.5 0.1 1.9 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF4200 PF13863.1 EDK41055.2 - 0.31 11.0 5.3 2.5 8.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) bZIP_1 PF00170.16 EDK41055.2 - 0.5 10.3 3.1 3.3 7.7 0.1 2.4 2 1 0 2 2 2 0 bZIP transcription factor Mod_r PF07200.8 EDK41055.2 - 0.57 10.0 4.8 0.83 9.5 0.8 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Rad10 PF03834.9 EDK41056.2 - 1.2e-29 101.7 0.3 2.9e-29 100.5 0.2 1.7 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.1 EDK41056.2 - 0.013 15.6 0.0 0.032 14.4 0.0 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain Neur_chan_memb PF02932.11 EDK41056.2 - 0.029 14.2 1.2 0.03 14.2 0.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mem_trans PF03547.13 EDK41056.2 - 0.29 9.3 1.4 0.29 9.4 1.0 1.1 1 0 0 1 1 1 0 Membrane transport protein Gag_spuma PF03276.9 EDK41056.2 - 0.34 9.1 26.1 0.48 8.6 18.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Sec62 PF03839.11 EDK41056.2 - 1.7 7.9 5.4 2.5 7.4 3.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PAT1 PF09770.4 EDK41056.2 - 2 6.5 21.8 2.6 6.1 15.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF3381 PF11861.3 EDK41056.2 - 3.7 7.0 11.9 7.3 6.0 7.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) HGTP_anticodon2 PF12745.2 EDK41056.2 - 6.4 5.8 13.2 13 4.7 8.4 1.9 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs Zip PF02535.17 EDK41056.2 - 8 5.3 10.5 12 4.8 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Fungal_trans PF04082.13 EDK41057.2 - 9.7e-14 50.8 6.6 1.4e-13 50.2 4.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41057.2 - 1.2e-09 37.8 7.9 2.5e-09 36.8 5.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CemA PF03040.9 EDK41057.2 - 0.00014 21.5 0.3 0.00028 20.5 0.2 1.4 1 0 0 1 1 1 1 CemA family MFS_1 PF07690.11 EDK41058.2 - 1.1e-12 47.3 51.7 8.9e-07 27.9 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nairovirus_M PF07948.6 EDK41058.2 - 0.18 9.9 2.7 0.3 9.1 1.8 1.3 1 0 0 1 1 1 0 Nairovirus M polyprotein-like DUF2108 PF09881.4 EDK41058.2 - 5.5 6.8 7.6 6.6 6.6 0.1 3.6 4 0 0 4 4 4 0 Predicted membrane protein (DUF2108) Metallophos PF00149.23 EDK41059.2 - 6.6e-17 61.5 6.3 5.4e-16 58.5 4.4 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EDK41059.2 - 0.0024 17.7 0.1 0.01 15.6 0.0 2.0 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain MFS_1 PF07690.11 EDK41060.2 - 2.9e-35 121.6 52.6 3e-35 121.5 33.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK41060.2 - 0.004 15.7 15.0 0.004 15.7 10.4 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Epimerase PF01370.16 EDK41061.1 - 6.8e-20 71.5 0.0 8.8e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK41061.1 - 1.1e-13 50.5 0.0 1.4e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK41061.1 - 5.8e-13 49.2 0.2 1.3e-12 48.1 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK41061.1 - 2.4e-10 39.7 0.1 1.4e-08 33.9 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EDK41061.1 - 3.4e-05 23.2 0.7 0.00014 21.1 0.2 2.0 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 EDK41061.1 - 0.00063 19.7 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 EDK41061.1 - 0.0059 15.5 0.1 0.012 14.4 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DapB_N PF01113.15 EDK41061.1 - 0.026 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 EDK41061.1 - 0.029 14.7 0.0 0.081 13.3 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Thioredoxin PF00085.15 EDK41062.2 - 7.1e-29 99.5 0.0 7.8e-29 99.4 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 EDK41062.2 - 1.4e-07 31.4 0.1 9e-07 28.9 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 EDK41062.2 - 2e-07 31.1 0.2 1.8e-06 28.1 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 EDK41062.2 - 3.1e-05 23.6 0.1 4.4e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Phosducin PF02114.11 EDK41062.2 - 9.4e-05 21.2 0.0 0.0001 21.1 0.0 1.0 1 0 0 1 1 1 1 Phosducin Redoxin PF08534.5 EDK41062.2 - 0.00013 21.5 0.1 0.0002 20.9 0.0 1.3 1 1 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 EDK41062.2 - 0.00016 21.2 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.1 EDK41062.2 - 0.00018 21.0 0.0 0.00027 20.4 0.0 1.3 1 1 0 1 1 1 1 F plasmid transfer operon protein DIM1 PF02966.11 EDK41062.2 - 0.00032 20.2 0.2 0.00099 18.6 0.1 1.7 1 1 0 1 1 1 1 Mitosis protein DIM1 Glutaredoxin PF00462.19 EDK41062.2 - 0.00042 20.2 0.1 0.00069 19.5 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 EDK41062.2 - 0.00076 19.2 0.0 0.00099 18.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.1 EDK41062.2 - 0.0049 16.8 0.1 0.01 15.8 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_5 PF13743.1 EDK41062.2 - 0.0078 15.7 0.1 0.15 11.5 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin DUF836 PF05768.9 EDK41062.2 - 0.01 16.0 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) HyaE PF07449.6 EDK41062.2 - 0.086 12.7 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE FmdA_AmdA PF03069.10 EDK41063.1 - 3.3e-142 473.5 0.0 3.8e-142 473.3 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family Ferric_reduct PF01794.14 EDK41064.2 - 1.4e-15 57.4 6.2 1.4e-15 57.4 4.3 2.2 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 EDK41064.2 - 9.1e-09 35.1 0.0 1.7e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain DUF4405 PF14358.1 EDK41064.2 - 0.09 12.9 0.4 0.09 12.9 0.3 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) ApbA_C PF08546.6 EDK41065.1 - 7.6e-28 97.0 0.3 1.7e-27 95.8 0.3 1.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EDK41065.1 - 0.057 12.8 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AA_permease PF00324.16 EDK41066.1 - 2.8e-70 237.0 42.1 3.2e-70 236.8 29.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK41066.1 - 1.1e-27 96.7 44.7 1.3e-27 96.4 31.0 1.0 1 0 0 1 1 1 1 Amino acid permease TauD PF02668.11 EDK41067.1 - 3.5e-45 154.6 0.1 4.4e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.11 EDK41068.2 - 4.4e-31 107.8 25.5 1.6e-30 105.9 18.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Lig_chan PF00060.21 EDK41068.2 - 0.057 13.1 0.9 0.24 11.1 0.6 2.1 1 0 0 1 1 1 0 Ligand-gated ion channel AAT PF03417.11 EDK41069.2 - 9.2e-27 93.9 0.0 1.3e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NAAA-beta PF15508.1 EDK41069.2 - 4.3e-05 23.7 0.1 8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Acetyltransf_11 PF13720.1 EDK41069.2 - 0.026 14.7 0.0 0.065 13.4 0.0 1.7 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Fungal_trans PF04082.13 EDK41070.2 - 3.8e-17 62.0 5.0 5.8e-17 61.4 3.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.17 EDK41071.2 - 1.1e-46 159.3 0.0 1.6e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.20 EDK41072.1 - 3.9e-20 72.4 0.3 2.5e-19 69.8 0.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41072.1 - 3.9e-17 62.8 0.2 1.2e-16 61.2 0.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41072.1 - 4.5e-10 39.4 1.1 1.5e-07 31.2 0.1 2.1 1 1 0 2 2 2 2 KR domain DUF1776 PF08643.5 EDK41072.1 - 0.0037 16.4 0.0 0.0064 15.6 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 EDK41072.1 - 0.005 16.2 0.0 0.0097 15.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EDK41072.1 - 0.0053 15.7 0.0 0.0073 15.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.13 EDK41072.1 - 0.098 12.3 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amidohydro_1 PF01979.15 EDK41074.2 - 3.9e-08 33.3 0.0 8.1e-08 32.2 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EDK41074.2 - 0.093 12.7 0.0 0.19 11.7 0.0 1.5 1 1 0 1 1 1 0 Amidohydrolase LRR_4 PF12799.2 EDK41075.2 - 3.8e-06 26.3 37.7 0.009 15.6 1.0 8.9 4 3 6 10 10 10 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK41075.2 - 5e-06 26.0 12.6 1.1 9.5 0.0 8.0 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.28 EDK41075.2 - 0.00048 19.7 30.1 0.066 13.2 0.1 8.8 8 3 2 10 10 10 3 Leucine Rich Repeat LRR_7 PF13504.1 EDK41075.2 - 0.0019 18.0 29.3 0.36 11.2 0.0 10.2 11 0 0 11 11 11 3 Leucine rich repeat CMS1 PF14617.1 EDK41075.2 - 0.074 12.1 0.2 1.1 8.2 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit LRR_8 PF13855.1 EDK41075.2 - 4.2 7.2 47.3 0.035 13.8 2.9 9.0 6 4 6 12 12 12 0 Leucine rich repeat MFS_1 PF07690.11 EDK41076.2 - 2e-23 82.7 20.8 2.6e-23 82.3 14.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 EDK41077.2 - 7e-05 21.7 0.5 8.7e-05 21.3 0.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 EDK41077.2 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1228) Amidohydro_4 PF13147.1 EDK41078.2 - 5.2e-16 59.5 0.0 3.1e-12 47.0 0.0 3.3 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EDK41078.2 - 3e-11 43.5 0.0 2.6e-07 30.6 0.0 3.2 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.6 EDK41078.2 - 5.3e-07 29.2 0.0 9.8e-05 21.7 0.0 3.0 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_5 PF13594.1 EDK41078.2 - 6.7e-07 29.0 0.0 1.8e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase Peptidase_M20 PF01546.23 EDK41079.2 - 9.1e-27 93.7 0.0 3.1e-26 92.0 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK41079.2 - 4.3e-09 36.1 0.0 7.8e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Amidohydro_4 PF13147.1 EDK41081.2 - 7.7e-14 52.3 0.1 9.6e-08 32.3 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EDK41081.2 - 2e-12 47.4 0.0 1.2e-11 44.9 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 EDK41081.2 - 3e-09 36.5 0.0 8.1e-09 35.1 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EDK41081.2 - 3.5e-08 33.0 0.0 1.1e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.11 EDK41082.2 - 9e-53 179.2 33.2 1.7e-52 178.3 23.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK41082.2 - 1.5e-13 50.1 12.9 1.5e-13 50.1 9.0 3.0 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.8 EDK41082.2 - 1.5e-06 26.7 8.0 1.5e-06 26.7 5.5 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans_2 PF11951.3 EDK41083.2 - 5.3e-16 58.1 0.9 7.4e-16 57.7 0.6 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_3 PF07969.6 EDK41084.2 - 2.5e-31 109.2 0.0 4.7e-31 108.4 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 EDK41084.2 - 2.8e-09 37.4 0.0 0.00016 21.8 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 EDK41084.2 - 3.2e-08 33.5 0.0 9.1e-07 28.8 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 EDK41084.2 - 8e-08 31.9 0.0 2.6e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.11 EDK41085.1 - 2.9e-26 92.0 22.1 2.9e-26 92.0 15.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK41085.1 - 1.2e-10 40.6 0.8 1.2e-10 40.6 0.6 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.11 EDK41086.2 - 3.5e-10 39.1 47.2 3.5e-10 39.1 32.7 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF2830 PF11125.3 EDK41086.2 - 0.068 12.8 1.8 1.2 8.9 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2830) MFS_1 PF07690.11 EDK41087.2 - 2.7e-35 121.7 37.1 2.7e-35 121.7 25.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 EDK41088.2 - 2.5e-23 82.3 26.2 2.5e-23 82.3 18.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N PF00107.21 EDK41089.2 - 4.7e-14 52.0 0.1 9.4e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK41089.2 - 1.1e-05 25.1 0.8 0.00021 21.0 0.4 3.0 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_N PF08240.7 EDK41090.1 - 6.3e-27 93.5 2.3 1.1e-26 92.6 1.4 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK41090.1 - 1.9e-17 62.9 0.0 3e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EDK41090.1 - 2.9e-05 23.2 0.1 5.7e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EDK41090.1 - 0.0012 18.4 0.0 0.0029 17.2 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 EDK41090.1 - 0.0055 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.15 EDK41090.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MR_MLE_C PF13378.1 EDK41091.1 - 2.1e-14 53.4 0.1 5.2e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE PF01188.16 EDK41091.1 - 5e-14 52.5 0.0 1.1e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 EDK41091.1 - 0.00076 19.4 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Sugar_tr PF00083.19 EDK41092.2 - 1.5e-92 310.5 25.5 1.7e-92 310.3 17.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41092.2 - 9.8e-28 96.8 36.8 3.4e-25 88.5 10.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1228 PF06779.9 EDK41092.2 - 0.0024 17.8 7.0 0.023 14.7 1.1 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1228) MtrG PF04210.8 EDK41092.2 - 0.25 11.0 5.5 10 5.8 2.0 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G PspC PF04024.7 EDK41092.2 - 0.25 10.8 7.4 1.2 8.6 1.2 2.8 2 0 0 2 2 2 0 PspC domain Fungal_trans PF04082.13 EDK41094.2 - 1.1e-56 191.6 4.8 2e-56 190.7 3.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 EDK41094.2 - 2.2e-08 33.9 8.5 0.0012 19.0 0.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK41094.2 - 3.1e-05 23.9 9.2 0.0076 16.5 0.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger Ogr_Delta PF04606.7 EDK41094.2 - 0.023 14.3 0.1 1.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger adh_short PF00106.20 EDK41095.2 - 2.3e-23 82.9 0.0 2.9e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41095.2 - 4.5e-22 78.9 0.1 5.6e-22 78.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41095.2 - 1.7e-13 50.6 0.0 2.1e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK41095.2 - 1.1e-06 28.7 0.4 2.2e-06 27.8 0.3 1.5 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 EDK41095.2 - 1.6e-05 24.4 0.1 2.7e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 EDK41095.2 - 4.2e-05 22.5 0.1 5.5e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 EDK41095.2 - 0.00027 20.2 1.3 0.0014 17.9 0.6 2.0 2 1 0 2 2 2 1 NmrA-like family DUF1776 PF08643.5 EDK41095.2 - 0.0064 15.6 0.0 0.013 14.6 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) TrkA_N PF02254.13 EDK41095.2 - 0.02 14.8 0.1 0.073 13.0 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Saccharop_dh PF03435.13 EDK41095.2 - 0.058 12.3 0.1 0.07 12.0 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 EDK41095.2 - 0.064 11.9 0.0 0.084 11.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HATPase_c PF02518.21 EDK41095.2 - 0.12 12.0 0.0 0.51 10.0 0.0 1.9 1 1 1 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase adh_short PF00106.20 EDK41096.2 - 3.3e-23 82.4 0.0 4.2e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41096.2 - 4.8e-15 55.9 0.0 5.7e-15 55.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41096.2 - 8.9e-12 45.0 0.0 1e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 EDK41096.2 - 3.3e-06 27.2 0.2 6.9e-06 26.1 0.2 1.7 1 1 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 EDK41096.2 - 0.0012 18.8 0.1 0.0039 17.1 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain Epimerase PF01370.16 EDK41096.2 - 0.0014 18.0 0.1 0.0029 17.0 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 EDK41096.2 - 0.0028 16.8 0.0 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 EDK41096.2 - 0.0097 14.9 0.1 0.015 14.3 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 EDK41096.2 - 0.019 15.4 0.2 1.2 9.5 0.0 2.8 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.10 EDK41096.2 - 0.024 13.5 0.2 0.037 12.9 0.1 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.19 EDK41096.2 - 0.036 14.3 0.0 0.23 11.7 0.0 2.2 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 EDK41096.2 - 0.036 12.7 0.1 0.06 12.0 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GrpB PF04229.9 EDK41096.2 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 GrpB protein DUF3589 PF12141.3 EDK41097.2 - 3.3e-132 441.2 0.0 4.5e-132 440.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) zf-MYND PF01753.13 EDK41097.2 - 0.12 12.3 0.1 0.12 12.3 0.1 2.4 2 0 0 2 2 2 0 MYND finger DUF4131 PF13567.1 EDK41097.2 - 0.19 11.1 2.1 0.32 10.3 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Sugar_tr PF00083.19 EDK41098.1 - 1.9e-152 508.0 35.1 2.1e-152 507.8 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41098.1 - 6.7e-26 90.8 47.4 2.1e-21 76.0 15.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.8 EDK41098.1 - 0.054 13.5 0.0 5.1 7.1 0.0 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LMF1 PF06762.9 EDK41098.1 - 3.1 6.5 7.8 0.14 10.8 0.4 2.0 1 1 1 2 2 2 0 Lipase maturation factor GFO_IDH_MocA PF01408.17 EDK41099.2 - 1.2e-22 80.7 0.0 1.7e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.11 EDK41099.2 - 0.012 15.9 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 EDK41099.2 - 0.026 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PhyH PF05721.8 EDK41100.1 - 5.5e-14 52.7 0.0 2.2e-13 50.7 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 EDK41100.1 - 0.015 15.7 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily AraC_binding PF02311.14 EDK41100.1 - 0.084 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AraC-like ligand binding domain Zn_clus PF00172.13 EDK41101.2 - 1.9e-05 24.4 10.0 5e-05 23.1 6.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 EDK41102.2 - 3.2e-06 26.9 10.3 3.2e-06 26.9 7.2 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 EDK41103.2 - 1.6e-06 27.8 7.8 3.1e-06 26.9 5.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.24 EDK41104.2 - 4.3e-59 199.8 8.2 1.4e-57 194.8 5.7 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK41104.2 - 4.8e-30 105.0 9.2 3.2e-23 82.6 1.8 2.6 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PMSR PF01625.16 EDK41105.1 - 2.3e-52 177.0 0.1 2.7e-52 176.7 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Hydantoinase_B PF02538.9 EDK41106.2 - 1.7e-188 627.1 0.2 2.4e-188 626.6 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 EDK41106.2 - 3.8e-83 278.9 0.0 6e-83 278.2 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EDK41106.2 - 2.8e-36 124.6 0.1 3.3e-34 117.8 0.0 2.7 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Fungal_trans PF04082.13 EDK41107.2 - 8.1e-17 60.9 1.0 1.5e-16 60.1 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 EDK41108.2 - 4.6e-30 104.5 26.2 4.6e-30 104.5 18.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3094 PF11293.3 EDK41108.2 - 0.24 10.8 2.4 3.1 7.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF2109 PF09882.4 EDK41108.2 - 0.26 11.2 11.8 5.6 6.9 0.2 4.2 3 1 0 3 3 3 0 Predicted membrane protein (DUF2109) Rep_fac_C PF08542.6 EDK41109.2 - 7.7e-21 73.8 0.0 2e-20 72.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 EDK41109.2 - 3.7e-10 39.7 0.1 8.1e-10 38.5 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 EDK41109.2 - 1.5e-07 31.7 0.2 4.9e-07 30.0 0.2 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41109.2 - 5.1e-07 29.8 0.3 0.00018 21.6 0.1 3.2 1 1 2 3 3 3 1 AAA domain Rad17 PF03215.10 EDK41109.2 - 1.4e-05 23.9 0.0 3e-05 22.9 0.0 1.6 1 1 1 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 EDK41109.2 - 0.00023 21.2 0.3 0.079 12.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 EDK41109.2 - 0.00026 21.0 0.1 0.0085 16.1 0.1 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.9 EDK41109.2 - 0.003 17.2 0.0 0.067 12.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.8 EDK41109.2 - 0.0077 15.7 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.16 EDK41109.2 - 0.011 14.8 0.0 0.074 12.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF3549 PF12069.3 EDK41109.2 - 0.02 13.6 0.3 0.032 12.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) ABC_tran PF00005.22 EDK41109.2 - 0.032 14.5 0.0 0.11 12.8 0.0 1.9 2 1 0 2 2 2 0 ABC transporter Dynamin_N PF00350.18 EDK41109.2 - 0.068 12.9 1.0 0.92 9.3 0.2 2.2 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.1 EDK41109.2 - 0.46 10.0 2.4 4.8 6.7 1.7 2.2 1 1 0 1 1 1 0 AAA domain Pmp3 PF01679.12 EDK41110.2 - 3.7e-13 48.9 3.9 4.6e-13 48.6 2.7 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Papilloma_E5 PF03025.9 EDK41110.2 - 0.072 13.0 3.7 0.1 12.5 2.5 1.2 1 0 0 1 1 1 0 Papillomavirus E5 Snf7 PF03357.16 EDK41111.2 - 3.1e-24 85.2 21.1 4.4e-24 84.7 14.6 1.3 1 1 0 1 1 1 1 Snf7 DUF796 PF05638.7 EDK41111.2 - 0.0071 16.3 2.0 0.0074 16.2 0.6 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF796) DUF2758 PF10957.3 EDK41111.2 - 0.24 11.2 2.4 0.24 11.2 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2758) Eno-Rase_FAD_bd PF07055.7 EDK41111.2 - 0.27 11.2 4.6 0.16 11.9 1.4 2.0 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Viral_P18 PF04521.8 EDK41111.2 - 1.6 8.1 8.9 4.9 6.6 2.1 2.7 2 1 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Ribosomal_L16 PF00252.13 EDK41113.1 - 3.6e-35 120.5 0.3 5.3e-35 120.0 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.15 EDK41114.2 - 2.1e-52 177.8 0.5 1.5e-25 89.8 0.0 2.9 2 1 1 3 3 3 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 EDK41114.2 - 1.1e-23 83.1 0.2 3.6e-23 81.5 0.0 2.0 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.15 EDK41114.2 - 1.7 7.3 5.7 2 7.0 0.1 2.9 3 1 1 4 4 4 0 tRNA synthetases class II (D, K and N) Flavodoxin_1 PF00258.20 EDK41115.2 - 8.9e-25 87.3 0.0 1.6e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.15 EDK41115.2 - 5.4e-24 84.8 0.0 1.1e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 EDK41115.2 - 3.5e-13 50.0 0.0 6.8e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Arch_ATPase PF01637.13 EDK41115.2 - 0.0029 17.3 0.0 0.0077 15.9 0.0 1.7 1 0 0 1 1 1 1 Archaeal ATPase Flavodoxin_5 PF12724.2 EDK41115.2 - 0.022 14.7 0.0 0.063 13.2 0.0 1.7 1 1 1 2 2 2 0 Flavodoxin domain Bromodomain PF00439.20 EDK41116.2 - 9.1e-34 115.2 2.2 1e-18 67.0 0.2 2.5 2 0 0 2 2 2 2 Bromodomain TrmE_N PF10396.4 EDK41117.2 - 4.3e-37 126.5 0.0 8.1e-37 125.6 0.0 1.5 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 EDK41117.2 - 1.1e-20 73.6 0.3 5.8e-20 71.3 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTPase_Cys_C PF12631.2 EDK41117.2 - 1.1e-14 54.5 0.0 2.7e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE FeoB_N PF02421.13 EDK41117.2 - 1.9e-10 40.2 0.0 3.4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EDK41117.2 - 2.4e-08 33.9 0.6 0.0037 17.1 0.0 2.7 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 EDK41117.2 - 3.5e-08 33.0 0.0 9.4e-06 25.1 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.11 EDK41117.2 - 1e-05 24.7 0.1 1.8e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 EDK41117.2 - 1.7e-05 25.2 0.1 9.8e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 EDK41117.2 - 0.001 18.4 0.0 0.0031 16.9 0.0 1.8 2 1 0 2 2 2 1 Ras family DUF258 PF03193.11 EDK41117.2 - 0.0019 17.4 0.0 0.0074 15.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 EDK41117.2 - 0.041 14.1 2.6 0.16 12.2 1.8 2.1 1 1 0 1 1 1 0 ABC transporter Anp1 PF03452.9 EDK41117.2 - 0.061 12.4 0.4 0.2 10.7 0.3 1.8 1 1 0 1 1 1 0 Anp1 AAA_28 PF13521.1 EDK41117.2 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ParA PF10609.4 EDK41118.1 - 4.7e-37 125.7 1.3 8.1e-37 124.9 0.2 1.9 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 EDK41118.1 - 2.5e-17 62.9 0.0 3.6e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 EDK41118.1 - 5.2e-10 39.4 0.0 2.4e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.6 EDK41118.1 - 5.2e-08 32.2 0.0 8.2e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.13 EDK41118.1 - 1.4e-05 24.4 0.1 0.0063 15.7 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.10 EDK41118.1 - 7.9e-05 21.8 1.8 0.0002 20.4 0.2 2.2 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.1 EDK41118.1 - 8.3e-05 22.2 0.6 0.24 10.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain YhjQ PF06564.7 EDK41118.1 - 0.00014 21.3 0.2 0.00055 19.3 0.0 1.8 2 0 0 2 2 2 1 YhjQ protein ArgK PF03308.11 EDK41118.1 - 0.01 14.6 0.2 0.017 13.8 0.1 1.3 1 0 0 1 1 1 0 ArgK protein SRP54 PF00448.17 EDK41118.1 - 0.013 14.9 0.2 0.026 13.9 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain VirC1 PF07015.6 EDK41118.1 - 0.024 13.6 0.4 0.057 12.4 0.1 1.6 2 0 0 2 2 2 0 VirC1 protein AAA_25 PF13481.1 EDK41118.1 - 0.11 11.8 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain CTP_transf_1 PF01148.15 EDK41120.2 - 7.2e-18 65.1 11.6 2.4e-16 60.1 4.1 2.1 1 1 1 2 2 2 2 Cytidylyltransferase family AMMECR1 PF01871.12 EDK41121.2 - 1.8e-42 144.3 0.0 2.3e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 LRR_1 PF00560.28 EDK41122.2 - 6.1e-13 46.8 17.4 0.075 13.1 0.3 7.9 6 2 1 7 7 7 4 Leucine Rich Repeat LRR_8 PF13855.1 EDK41122.2 - 1.3e-12 47.3 26.6 3.7e-06 26.5 9.2 4.6 5 1 0 5 5 5 3 Leucine rich repeat LRR_4 PF12799.2 EDK41122.2 - 1.1e-11 44.0 26.8 1.2e-05 24.7 11.3 5.8 3 2 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 EDK41122.2 - 2.6e-09 36.1 22.6 0.073 13.1 0.9 6.9 7 0 0 7 7 7 4 Leucine Rich repeat LRR_7 PF13504.1 EDK41122.2 - 0.00017 21.2 19.1 0.092 13.0 0.2 7.6 7 0 0 7 7 7 1 Leucine rich repeat F-box-like PF12937.2 EDK41122.2 - 0.069 12.8 0.8 0.24 11.1 0.5 2.0 1 0 0 1 1 1 0 F-box-like LAMTOR PF15454.1 EDK41123.2 - 5e-14 52.3 4.7 5e-14 52.3 3.3 1.5 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF970 PF06153.6 EDK41123.2 - 0.026 14.4 0.3 0.056 13.4 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF970) TEX33 PF15400.1 EDK41123.2 - 0.035 14.5 0.9 0.05 14.0 0.2 1.6 2 0 0 2 2 2 0 Testis-expressed sequence 33 protein family Arch_flagellin PF01917.11 EDK41123.2 - 0.046 13.3 0.8 0.055 13.0 0.6 1.2 1 0 0 1 1 1 0 Archaebacterial flagellin PRCC PF10253.4 EDK41124.2 - 0.0042 17.8 4.5 0.0042 17.8 3.1 1.7 2 0 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting DUF1777 PF08648.7 EDK41125.2 - 3.5 7.3 22.4 5.7 6.6 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Pkinase PF00069.20 EDK41126.2 - 8.9e-70 234.7 0.0 4e-69 232.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41126.2 - 1.3e-34 119.4 0.0 9.7e-33 113.3 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.14 EDK41126.2 - 4.3e-18 64.4 0.9 9.5e-18 63.3 0.0 1.9 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.1 EDK41126.2 - 3.6e-05 22.8 0.0 6.6e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK41126.2 - 4.3e-05 22.6 0.0 7.5e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 EDK41126.2 - 0.014 15.0 0.1 0.08 12.6 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family WaaY PF06176.6 EDK41126.2 - 0.055 12.6 0.1 0.089 12.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Seadorna_VP7 PF07387.6 EDK41126.2 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.4 EDK41126.2 - 2.6 7.3 7.4 0.089 12.1 0.2 2.1 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL Pyr_redox_3 PF13738.1 EDK41127.2 - 9.7e-06 25.7 0.0 0.00081 19.4 0.0 2.4 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 EDK41127.2 - 7.2e-05 22.7 0.0 0.00017 21.5 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK41127.2 - 0.00045 20.0 0.0 0.0027 17.5 0.0 2.3 2 1 1 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.22 EDK41127.2 - 0.026 14.9 0.0 0.48 10.8 0.1 2.8 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase zf-HIT PF04438.11 EDK41128.2 - 0.013 15.1 13.7 0.02 14.5 9.5 1.3 1 0 0 1 1 1 0 HIT zinc finger DASH_Ask1 PF08655.5 EDK41129.2 - 1.9e-29 101.2 0.7 1.9e-29 101.2 0.5 2.0 2 0 0 2 2 2 1 DASH complex subunit Ask1 Complex1_LYR PF05347.10 EDK41130.2 - 1.3e-12 47.3 1.1 1.5e-12 47.0 0.7 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 EDK41130.2 - 1.6e-09 37.8 0.8 1.8e-09 37.6 0.6 1.1 1 0 0 1 1 1 1 Complex1_LYR-like DUF4130 PF13566.1 EDK41130.2 - 0.068 12.7 0.5 0.14 11.6 0.2 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4130 UPF0113 PF03657.8 EDK41130.2 - 0.098 12.3 0.0 4.9 6.7 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0113) RhoGAP PF00620.22 EDK41131.2 - 6.3e-43 146.0 0.1 1.7e-42 144.6 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 EDK41131.2 - 2.2e-13 50.0 25.6 3.2e-08 33.4 5.7 2.5 2 0 0 2 2 2 2 LIM domain ERM PF00769.14 EDK41131.2 - 0.0027 17.2 3.6 0.0027 17.2 2.5 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family DUF972 PF06156.8 EDK41131.2 - 0.0056 17.0 8.1 0.009 16.3 0.2 3.6 2 1 1 3 3 3 1 Protein of unknown function (DUF972) DUF904 PF06005.7 EDK41131.2 - 0.16 12.3 10.0 0.14 12.4 0.4 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF904) HALZ PF02183.13 EDK41131.2 - 8.9 6.1 9.1 0.77 9.5 0.1 3.7 4 1 0 5 5 5 0 Homeobox associated leucine zipper Glyco_transf_21 PF13506.1 EDK41132.2 - 6.4e-16 58.1 0.0 2.8e-08 33.2 0.0 3.2 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 EDK41132.2 - 2.2e-12 47.2 0.0 6.8e-10 39.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 EDK41132.2 - 6.3e-07 29.2 0.0 0.0012 18.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Carn_acyltransf PF00755.15 EDK41133.2 - 3.4e-186 619.8 0.0 3.8e-186 619.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RFX_DNA_binding PF02257.10 EDK41134.2 - 2.2e-11 43.7 0.5 2.7e-10 40.2 0.3 2.4 1 1 0 1 1 1 1 RFX DNA-binding domain Pribosyl_synth PF14572.1 EDK41135.2 - 3.9e-39 134.2 2.6 2.5e-35 121.8 0.7 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 EDK41135.2 - 1.1e-37 128.3 1.8 2e-36 124.2 0.1 2.4 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 EDK41135.2 - 1.1e-13 50.9 0.8 3.3e-13 49.4 0.5 1.8 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 EDK41135.2 - 0.00032 19.9 0.1 0.00055 19.1 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ATG11 PF10377.4 EDK41136.2 - 7.9e-37 126.0 0.7 7.9e-37 126.0 0.5 2.6 2 0 0 2 2 2 1 Autophagy-related protein 11 Baculo_PEP_C PF04513.7 EDK41136.2 - 0.037 13.8 14.2 0.1 12.4 0.0 5.2 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.1 EDK41136.2 - 0.33 10.9 0.1 0.33 10.9 0.0 4.5 4 1 1 5 5 5 0 CENP-Q, a CENPA-CAD centromere complex subunit Reo_sigmaC PF04582.7 EDK41136.2 - 5 6.1 10.8 0.89 8.6 0.9 3.3 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Atg14 PF10186.4 EDK41136.2 - 7.9 5.3 28.5 0.2 10.5 9.8 3.6 4 0 0 4 4 4 0 UV radiation resistance protein and autophagy-related subunit 14 DUF336 PF03928.9 EDK41137.2 - 2.9e-11 43.2 0.0 3.5e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF336) DUF336 PF03928.9 EDK41138.2 - 9.6e-23 80.4 0.0 1.1e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF336) RXT2_N PF08595.6 EDK41139.2 - 3.7e-43 146.8 1.2 3.7e-43 146.8 0.8 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal Vir_act_alpha_C PF10400.4 EDK41139.2 - 0.22 11.9 2.2 9.2 6.7 0.0 2.9 2 1 1 3 3 3 0 Virulence activator alpha C-term PCNA_N PF00705.13 EDK41140.1 - 1.4e-47 160.3 2.3 1.4e-47 160.3 1.6 2.2 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 EDK41140.1 - 7.2e-47 158.5 0.0 1.1e-46 157.8 0.0 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 EDK41140.1 - 1.8e-08 33.8 0.1 2.3e-08 33.4 0.1 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.11 EDK41140.1 - 8.5e-08 31.2 1.5 2.7e-05 23.0 0.4 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.7 EDK41140.1 - 6.3e-06 25.3 0.0 0.015 14.3 0.0 2.1 2 0 0 2 2 2 2 Hus1-like protein Acetyltransf_1 PF00583.19 EDK41141.1 - 5.7e-15 55.1 0.0 8.7e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 EDK41141.1 - 1e-09 38.6 0.0 1.2e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EDK41141.1 - 1.2e-09 38.2 0.0 1.5e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK41141.1 - 2.5e-09 37.1 0.0 3.6e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EDK41141.1 - 5.7e-09 35.6 0.0 9.5e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 EDK41141.1 - 5.6e-07 29.6 0.0 7.2e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK41141.1 - 0.0039 17.0 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.1 EDK41141.1 - 0.0063 16.3 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 EDK41141.1 - 0.074 12.9 0.0 0.12 12.3 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain F_bP_aldolase PF01116.15 EDK41142.1 - 1.4e-76 257.3 0.0 1.7e-76 257.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II zf-Tim10_DDP PF02953.10 EDK41143.1 - 5.6e-16 57.5 3.4 6.5e-16 57.3 2.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.10 EDK41144.2 - 1.9e-64 217.4 0.3 4.5e-64 216.2 0.2 1.5 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 EDK41144.2 - 5.6e-44 149.8 0.0 1.2e-43 148.6 0.0 1.6 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.1 EDK41144.2 - 3.4e-05 22.7 0.5 0.01 14.6 0.0 3.0 3 0 0 3 3 3 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 EDK41144.2 - 0.00012 21.9 0.0 0.00027 20.7 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.9 EDK41144.2 - 0.014 15.3 0.1 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.6 EDK41144.2 - 0.024 14.1 0.1 0.41 10.1 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain CUE PF02845.11 EDK41145.2 - 4.9e-09 35.5 0.3 7.1e-09 34.9 0.2 1.3 1 0 0 1 1 1 1 CUE domain CDC27 PF09507.5 EDK41145.2 - 0.22 10.6 30.9 0.32 10.1 21.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF2217 PF10265.4 EDK41145.2 - 0.23 10.1 8.8 0.3 9.8 6.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF605 PF04652.11 EDK41145.2 - 1.5 8.1 24.8 1.7 7.9 17.2 1.2 1 0 0 1 1 1 0 Vta1 like Mitofilin PF09731.4 EDK41145.2 - 4.3 5.8 19.8 5.9 5.4 13.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein HMG_box PF00505.14 EDK41147.1 - 1.5e-24 86.0 2.1 1.5e-24 86.0 1.4 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EDK41147.1 - 8.3e-20 70.9 1.6 1.3e-19 70.2 1.1 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 EDK41147.1 - 5.8e-05 22.8 2.3 5.8e-05 22.8 1.6 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box 5 CHDNT PF08073.7 EDK41147.1 - 0.00032 20.3 0.0 0.00049 19.7 0.0 1.2 1 0 0 1 1 1 1 CHDNT (NUC034) domain DUF1014 PF06244.7 EDK41147.1 - 0.013 15.6 1.0 0.043 14.0 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1014) YABBY PF04690.8 EDK41147.1 - 0.08 13.1 0.3 0.12 12.5 0.1 1.4 1 1 0 1 1 1 0 YABBY protein AATase PF07247.7 EDK41148.2 - 2e-66 224.5 0.1 3.1e-66 223.8 0.0 1.3 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 EDK41148.2 - 0.00011 21.1 0.0 0.0035 16.2 0.0 2.2 2 0 0 2 2 2 2 Condensation domain DUF89 PF01937.14 EDK41149.1 - 2.6e-118 394.8 3.3 2.9e-118 394.7 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Syntaxin_2 PF14523.1 EDK41149.1 - 0.71 9.9 3.2 29 4.7 0.0 3.1 4 0 0 4 4 4 0 Syntaxin-like protein TFIIA_gamma_C PF02751.9 EDK41150.2 - 3.7e-27 93.8 0.7 5.4e-27 93.3 0.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 EDK41150.2 - 1.3e-24 85.5 0.5 1.9e-24 84.9 0.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain DapH_N PF08503.5 EDK41150.2 - 0.025 14.6 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal Nup160 PF11715.3 EDK41151.2 - 6.5e-40 136.7 5.3 1e-39 136.1 3.7 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 SBDS PF01172.13 EDK41151.2 - 0.052 13.3 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF4144 PF13642.1 EDK41152.2 - 0.012 15.9 0.7 0.17 12.2 0.1 2.2 2 0 0 2 2 2 0 protein structure with unknown function DUF3072 PF11272.3 EDK41152.2 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) FAD_binding_2 PF00890.19 EDK41152.2 - 0.097 11.5 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Bul1_N PF04425.7 EDK41153.2 - 5e-149 496.6 6.1 5e-149 496.6 4.2 2.0 1 1 1 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 EDK41153.2 - 5.6e-14 51.9 13.5 2.7e-08 33.3 0.1 4.3 3 1 0 4 4 4 3 Bul1 C terminus GATase PF00117.23 EDK41154.2 - 1.5e-44 151.8 0.0 2e-44 151.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.17 EDK41154.2 - 7.9e-41 138.6 0.0 1.4e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.8 EDK41154.2 - 0.00016 21.2 0.2 0.0015 17.9 0.0 2.3 1 1 1 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.19 EDK41154.2 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family FA_hydroxylase PF04116.8 EDK41155.2 - 1.3e-13 51.3 22.4 1.3e-13 51.3 15.5 1.9 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily adh_short PF00106.20 EDK41156.2 - 1.7e-33 115.8 0.0 2.4e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41156.2 - 1.7e-13 50.8 0.1 2.5e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41156.2 - 4.2e-12 46.0 0.0 6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 EDK41156.2 - 0.00029 19.8 0.0 0.0006 18.8 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 EDK41156.2 - 0.00069 19.3 0.3 0.0014 18.3 0.2 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 EDK41156.2 - 0.0016 17.8 0.0 0.0028 17.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Racemase_4 PF13615.1 EDK41156.2 - 0.033 14.4 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative alanine racemase NAD_binding_10 PF13460.1 EDK41156.2 - 0.061 13.3 0.2 0.21 11.5 0.1 2.0 1 1 0 1 1 1 0 NADH(P)-binding ATP_bind_3 PF01171.15 EDK41157.2 - 9.5e-19 67.5 0.0 4.9e-18 65.2 0.0 2.2 3 1 0 3 3 3 1 PP-loop family DUF2392 PF10288.4 EDK41157.2 - 0.0071 16.6 0.0 0.022 15.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2392) DUF3970 PF13113.1 EDK41157.2 - 0.49 10.1 3.7 1.3 8.7 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) HNH PF01844.18 EDK41157.2 - 0.85 9.5 10.2 26 4.7 0.2 3.9 3 1 1 4 4 4 0 HNH endonuclease DUF4428 PF14471.1 EDK41157.2 - 1.6 8.5 11.2 0.13 12.0 0.7 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) DZR PF12773.2 EDK41157.2 - 4.5 7.1 10.3 6.1 6.7 0.4 3.1 3 0 0 3 3 3 0 Double zinc ribbon DUF2616 PF11077.3 EDK41157.2 - 5 6.5 9.0 1 8.8 0.7 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) Cytochrom_c3_2 PF14537.1 EDK41157.2 - 7.5 6.9 10.4 1.7 9.0 0.6 2.5 2 0 0 2 2 2 0 Cytochrome c3 eIF-3c_N PF05470.7 EDK41158.2 - 6.8e-147 490.0 6.9 1.9e-113 379.6 0.2 3.0 3 1 1 4 4 4 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 EDK41158.2 - 4.9e-09 36.4 2.4 1.2e-08 35.2 0.5 2.6 2 1 0 2 2 2 1 PCI domain MIT PF04212.13 EDK41159.2 - 0.0046 16.8 0.1 0.014 15.2 0.1 1.9 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Tbf5 PF06331.7 EDK41160.2 - 0.04 13.6 0.4 0.27 11.0 0.0 2.4 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 NMT PF01233.14 EDK41161.2 - 1.4e-79 265.3 0.3 2.4e-79 264.6 0.0 1.5 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 EDK41161.2 - 1.4e-77 259.3 0.8 2.5e-77 258.5 0.6 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_7 PF13508.1 EDK41161.2 - 0.081 13.0 0.0 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WD40 PF00400.27 EDK41162.1 - 5.4e-17 60.9 11.5 2.6e-08 33.4 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 EDK41162.1 - 0.0086 14.2 0.1 0.12 10.5 0.1 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_3 PF13570.1 EDK41162.1 - 0.1 12.8 0.3 0.92 9.8 0.0 2.7 3 0 0 3 3 3 0 PQQ-like domain ABC_tran PF00005.22 EDK41163.1 - 8.2e-50 168.6 0.4 6.2e-24 84.8 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 EDK41163.1 - 3.1e-20 71.7 1.1 3.1e-20 71.7 0.8 3.3 4 1 0 4 4 1 1 ABC transporter AAA_21 PF13304.1 EDK41163.1 - 1.3e-19 71.2 3.9 1.2e-05 25.3 0.0 4.3 2 2 1 4 4 4 4 AAA domain SMC_N PF02463.14 EDK41163.1 - 5e-10 38.9 1.8 0.035 13.3 0.1 4.5 4 1 0 4 4 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 EDK41163.1 - 1.9e-08 33.6 0.0 0.0017 17.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 EDK41163.1 - 3.6e-08 33.6 0.1 0.013 15.6 0.0 3.1 3 1 0 3 3 2 2 AAA domain AAA_17 PF13207.1 EDK41163.1 - 7.5e-08 33.2 0.2 0.031 15.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 EDK41163.1 - 7.2e-07 29.3 4.9 0.013 15.5 0.0 3.4 4 1 0 4 4 4 2 AAA ATPase domain DUF258 PF03193.11 EDK41163.1 - 1.1e-06 27.9 0.0 0.0015 17.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_18 PF13238.1 EDK41163.1 - 3.4e-06 27.3 1.5 0.012 15.8 0.0 3.5 4 0 0 4 4 2 2 AAA domain NACHT PF05729.7 EDK41163.1 - 7.4e-06 25.7 0.4 0.085 12.5 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Miro PF08477.8 EDK41163.1 - 8.9e-06 26.1 3.8 0.018 15.5 0.0 3.2 4 0 0 4 4 2 2 Miro-like protein AAA_23 PF13476.1 EDK41163.1 - 3e-05 24.4 15.4 0.12 12.6 0.0 4.3 4 0 0 4 4 3 2 AAA domain RNA_helicase PF00910.17 EDK41163.1 - 5.3e-05 23.3 0.0 0.67 10.1 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.1 EDK41163.1 - 5.6e-05 23.0 0.0 0.49 10.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 EDK41163.1 - 8.9e-05 22.0 0.2 1.6 8.0 0.0 3.4 3 0 0 3 3 3 2 AAA-like domain AAA PF00004.24 EDK41163.1 - 9.1e-05 22.6 0.0 0.73 10.0 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 EDK41163.1 - 0.0001 21.2 0.0 0.083 11.7 0.0 2.5 2 1 0 2 2 2 2 NB-ARC domain MMR_HSR1 PF01926.18 EDK41163.1 - 0.00011 22.1 0.2 0.3 11.0 0.1 3.3 3 1 0 3 3 2 2 50S ribosome-binding GTPase AAA_5 PF07728.9 EDK41163.1 - 0.00011 21.8 0.1 0.37 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 EDK41163.1 - 0.00015 21.8 0.7 0.54 10.1 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.1 EDK41163.1 - 0.00019 20.5 0.0 0.24 10.4 0.0 3.3 3 1 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.1 EDK41163.1 - 0.00029 20.2 0.0 2 7.7 0.0 3.4 3 1 0 3 3 3 2 AAA domain MobB PF03205.9 EDK41163.1 - 0.00037 20.2 0.2 0.07 12.8 0.0 3.2 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 EDK41163.1 - 0.00049 19.9 0.8 0.46 10.3 0.0 3.1 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.8 EDK41163.1 - 0.0025 16.7 0.0 0.75 8.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) MCM PF00493.18 EDK41163.1 - 0.0031 16.3 1.2 0.36 9.5 0.0 2.5 3 0 0 3 3 3 1 MCM2/3/5 family Arch_ATPase PF01637.13 EDK41163.1 - 0.0031 17.2 7.0 0.16 11.6 0.0 3.5 4 0 0 4 4 3 2 Archaeal ATPase DAP3 PF10236.4 EDK41163.1 - 0.0053 15.7 1.2 1.9 7.3 0.0 2.9 3 0 0 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 Ras PF00071.17 EDK41163.1 - 0.0061 15.9 0.1 4.1 6.7 0.0 2.8 3 0 0 3 3 3 0 Ras family SbcCD_C PF13558.1 EDK41163.1 - 0.0069 16.2 0.7 0.19 11.6 0.1 3.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.4 EDK41163.1 - 0.0085 15.5 0.5 9.4 5.7 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 EDK41163.1 - 0.011 15.4 0.0 1.4 8.5 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.1 EDK41163.1 - 0.011 15.2 0.0 1.8 8.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 EDK41163.1 - 0.024 13.5 0.0 0.39 9.5 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein ArgK PF03308.11 EDK41163.1 - 0.033 12.9 0.1 4.5 5.9 0.0 2.9 3 0 0 3 3 3 0 ArgK protein ATP-synt_ab PF00006.20 EDK41163.1 - 0.075 12.5 0.0 0.34 10.3 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_13 PF13166.1 EDK41163.1 - 0.26 9.6 8.4 14 3.9 0.0 4.0 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.18 EDK41163.1 - 1.3 8.8 8.7 5.5 6.7 0.0 4.1 3 1 1 4 4 4 0 Dynamin family DUF87 PF01935.12 EDK41163.1 - 4.1 7.1 10.5 17 5.1 0.0 4.0 4 1 1 5 5 4 0 Domain of unknown function DUF87 DUF3437 PF11919.3 EDK41164.2 - 2.9e-29 100.5 0.0 1.2e-28 98.6 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) NOA36 PF06524.7 EDK41164.2 - 2.5 7.2 9.2 4.4 6.4 6.4 1.3 1 0 0 1 1 1 0 NOA36 protein EF-hand_1 PF00036.27 EDK41165.2 - 1e-12 46.3 0.5 0.00028 19.9 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 EDK41165.2 - 1e-11 43.6 2.0 0.00095 18.8 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 EDK41165.2 - 1.4e-11 43.1 0.3 0.0001 21.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 EDK41165.2 - 3.6e-09 36.6 0.2 0.00049 20.1 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 EDK41165.2 - 0.0023 17.4 0.9 1.2 8.7 0.0 3.4 3 1 0 3 3 3 2 EF-hand domain pair Glycos_transf_2 PF00535.21 EDK41167.2 - 0.025 14.2 0.1 0.065 12.9 0.1 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Septin PF00735.13 EDK41168.1 - 2.1e-74 250.0 0.0 3.6e-74 249.2 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 EDK41168.1 - 5.9e-05 22.9 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 EDK41168.1 - 0.0014 17.8 0.0 0.004 16.2 0.0 1.7 2 0 0 2 2 2 1 AIG1 family DUF91 PF01939.11 EDK41168.1 - 0.0095 15.1 0.1 0.017 14.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF91 DUF258 PF03193.11 EDK41168.1 - 0.013 14.6 0.0 0.044 12.9 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 EDK41168.1 - 0.014 15.7 1.3 0.067 13.4 0.0 2.3 2 1 0 2 2 2 0 ABC transporter AAA_17 PF13207.1 EDK41168.1 - 0.017 15.9 0.1 0.11 13.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.7 EDK41168.1 - 0.018 14.2 0.1 0.051 12.7 0.0 1.8 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Ras PF00071.17 EDK41168.1 - 0.026 13.8 0.1 0.32 10.3 0.0 2.4 2 0 0 2 2 2 0 Ras family AAA_10 PF12846.2 EDK41168.1 - 0.042 13.2 0.0 0.098 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA-like domain Dynamin_N PF00350.18 EDK41168.1 - 0.045 13.5 0.2 1.3 8.8 0.0 2.9 3 0 0 3 3 3 0 Dynamin family T2SE PF00437.15 EDK41168.1 - 0.095 11.5 0.0 0.25 10.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 EDK41168.1 - 0.095 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 EDK41168.1 - 0.096 12.8 0.7 0.42 10.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain cobW PF02492.14 EDK41168.1 - 0.13 11.7 0.8 1.2 8.5 0.3 2.6 2 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 EDK41168.1 - 0.35 10.8 3.5 1.4 8.8 0.1 3.0 2 1 1 3 3 3 0 AAA domain PIN_4 PF13638.1 EDK41169.1 - 1.2e-06 28.6 0.0 1.6e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 PIN domain QLQ PF08880.6 EDK41170.2 - 2.1e-13 49.4 3.2 2.1e-13 49.4 2.2 4.5 5 0 0 5 5 5 1 QLQ HSA PF07529.8 EDK41170.2 - 5.6e-05 22.8 8.3 5.6e-05 22.8 5.8 2.3 2 0 0 2 2 2 1 HSA SNF2_N PF00176.18 EDK41171.2 - 4.7e-77 258.7 1.0 7.1e-77 258.1 0.7 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 EDK41171.2 - 3.7e-18 65.1 0.0 2.6e-16 59.2 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.1 EDK41171.2 - 3.2e-16 59.2 4.7 6.5e-16 58.2 0.7 2.8 1 1 1 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex HDA2-3 PF11496.3 EDK41171.2 - 5.4e-09 35.2 0.5 1.2e-08 34.1 0.3 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 EDK41171.2 - 5.8e-07 29.5 1.4 9e-07 28.8 0.1 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RrnaAD PF00398.15 EDK41172.2 - 4e-29 101.4 0.0 5.5e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.1 EDK41172.2 - 0.042 13.5 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RICTOR_M PF14666.1 EDK41172.2 - 0.045 12.7 0.0 0.079 11.9 0.0 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Methyltransf_31 PF13847.1 EDK41172.2 - 0.15 11.6 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Vps36_ESCRT-II PF11605.3 EDK41173.2 - 0.00016 21.3 0.1 0.00044 20.0 0.0 1.7 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 EDK41173.2 - 0.021 14.3 0.1 0.058 12.9 0.0 1.7 1 1 0 1 1 1 0 GRAM domain bPH_3 PF14470.1 EDK41173.2 - 0.048 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial PH domain Suf PF05843.9 EDK41174.2 - 9.6e-73 245.3 12.8 8.6e-72 242.1 1.0 3.6 2 1 0 2 2 2 2 Suppressor of forked protein (Suf) TPR_19 PF14559.1 EDK41174.2 - 4.1e-05 23.8 0.0 0.17 12.2 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat Fib_alpha PF08702.5 EDK41174.2 - 0.21 11.7 13.3 0.035 14.2 1.6 3.4 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family Tom37_C PF11801.3 EDK41175.2 - 7.3e-57 191.8 0.1 1e-56 191.3 0.1 1.2 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.4 EDK41175.2 - 2.3e-25 88.6 0.3 5.3e-25 87.4 0.2 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein DUF4448 PF14610.1 EDK41176.2 - 9e-60 201.4 0.3 9e-60 201.4 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4448) DUF658 PF04936.7 EDK41176.2 - 0.076 12.8 1.6 1.3 8.8 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF658) Zip PF02535.17 EDK41177.2 - 4.3e-26 91.6 17.0 9.3e-26 90.5 11.8 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter PNRC PF15365.1 EDK41178.2 - 0.0001 22.1 2.5 0.0001 22.1 1.8 3.1 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator Cation_efflux PF01545.16 EDK41179.2 - 8.3e-78 261.3 2.2 1.3e-77 260.6 1.6 1.2 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 EDK41179.2 - 0.0094 14.9 0.1 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter Opi1 PF08618.5 EDK41182.2 - 2.9e-24 85.7 14.0 1.2e-12 47.5 5.1 3.4 1 1 2 3 3 3 3 Transcription factor Opi1 Cortex-I_coil PF09304.5 EDK41182.2 - 0.0021 18.0 4.5 0.0051 16.8 3.2 1.6 1 0 0 1 1 1 1 Cortexillin I, coiled coil DNA_pol3_a_NII PF11490.3 EDK41182.2 - 0.051 13.1 3.2 0.15 11.6 2.2 1.8 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DUF1675 PF07897.6 EDK41182.2 - 9 6.0 13.6 2.7 7.7 7.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) PTR2 PF00854.16 EDK41183.1 - 8.4e-54 182.7 19.1 1.2e-53 182.3 13.2 1.2 1 0 0 1 1 1 1 POT family DUF1435 PF07256.7 EDK41183.1 - 0.27 11.2 2.6 19 5.3 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) S1 PF00575.18 EDK41184.2 - 1.5e-73 242.8 47.1 1.4e-15 57.1 0.8 13.1 13 0 0 13 13 13 12 S1 RNA binding domain TPR_19 PF14559.1 EDK41184.2 - 2.3e-07 31.0 0.6 0.057 13.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Suf PF05843.9 EDK41184.2 - 5.8e-07 29.5 1.9 5.8e-07 29.5 1.3 4.5 3 2 2 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EDK41184.2 - 7.6e-05 23.0 0.0 5.8 7.8 0.0 4.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK41184.2 - 0.049 13.2 0.0 0.3 10.7 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.1 EDK41184.2 - 0.2 12.3 0.0 23 5.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat BRAP2 PF07576.7 EDK41185.2 - 3.1e-26 91.0 0.5 7e-26 89.9 0.0 1.8 2 0 0 2 2 2 1 BRCA1-associated protein 2 zf-UBP PF02148.14 EDK41185.2 - 4.7e-19 68.2 4.6 1.1e-18 67.1 3.2 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 EDK41185.2 - 5.9e-09 35.6 10.3 5.9e-09 35.6 7.2 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EDK41185.2 - 7.8e-06 25.4 6.1 7.8e-06 25.4 4.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK41185.2 - 1.8e-05 24.3 8.2 1.8e-05 24.3 5.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK41185.2 - 0.00018 21.4 10.4 0.00018 21.4 7.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK41185.2 - 0.00052 20.0 4.9 0.00052 20.0 3.4 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 EDK41185.2 - 0.00053 19.5 10.3 0.00053 19.5 7.2 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 EDK41185.2 - 0.0012 18.5 4.5 0.0036 17.0 1.4 2.7 1 1 1 2 2 2 1 RING-type zinc-finger NPV_P10 PF05531.7 EDK41185.2 - 0.0081 16.3 7.2 0.029 14.6 1.8 2.5 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein TerY-C PF15616.1 EDK41185.2 - 0.016 15.1 2.8 0.016 15.1 1.9 2.7 2 1 1 3 3 2 0 TerY-C metal binding domain zf-RING_6 PF14835.1 EDK41185.2 - 0.32 10.8 4.7 1.2 8.9 3.3 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 EDK41185.2 - 0.48 10.3 7.8 2.4 8.1 5.4 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING SlyX PF04102.7 EDK41185.2 - 0.64 10.4 6.6 0.12 12.7 1.2 2.3 2 1 0 2 2 2 0 SlyX DUF948 PF06103.6 EDK41185.2 - 0.71 9.7 4.8 1.3 8.9 0.8 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) IncA PF04156.9 EDK41185.2 - 0.76 9.3 13.7 0.52 9.8 6.5 2.4 2 1 0 2 2 1 0 IncA protein ArfGap PF01412.13 EDK41185.2 - 1 9.1 8.7 0.038 13.7 1.1 2.2 3 0 0 3 3 2 0 Putative GTPase activating protein for Arf DivIC PF04977.10 EDK41185.2 - 1.1 8.7 8.3 0.3 10.6 0.6 3.0 1 1 2 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.3 EDK41185.2 - 1.4 8.7 11.8 1.1 9.1 5.6 2.5 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Cript PF10235.4 EDK41185.2 - 1.5 9.2 7.6 0.16 12.3 0.9 2.2 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT zf-Apc11 PF12861.2 EDK41185.2 - 1.6 8.6 11.2 0.047 13.5 3.1 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1664 PF07889.7 EDK41185.2 - 1.7 8.4 6.3 1.5 8.6 2.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.16 EDK41185.2 - 2.4 8.1 11.4 0.72 9.8 1.1 3.4 3 0 0 3 3 3 0 bZIP transcription factor zf-Sec23_Sec24 PF04810.10 EDK41185.2 - 4.6 6.8 12.7 4 7.0 0.9 2.9 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger FlaC_arch PF05377.6 EDK41185.2 - 6.9 6.6 7.3 19 5.2 0.4 3.3 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) DUF972 PF06156.8 EDK41185.2 - 8 6.8 11.7 2.5 8.4 4.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Pkinase PF00069.20 EDK41186.2 - 7.5e-61 205.5 0.0 2.3e-60 203.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41186.2 - 4e-48 163.7 0.0 7e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK41186.2 - 0.002 17.1 0.0 0.0036 16.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like ADH_zinc_N PF00107.21 EDK41187.2 - 1.9e-26 92.1 1.1 3.6e-26 91.2 0.8 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK41187.2 - 1.9e-05 25.5 0.0 4.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.11 EDK41187.2 - 0.0079 16.5 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II SIS_2 PF13580.1 EDK41187.2 - 0.14 11.8 3.0 0.15 11.7 0.5 2.1 2 1 1 3 3 3 0 SIS domain ADH_zinc_N PF00107.21 EDK41188.1 - 1.5e-28 98.9 0.2 4.8e-28 97.3 0.3 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK41188.1 - 1.3e-05 26.0 0.1 5.5e-05 24.0 0.0 2.0 3 0 0 3 3 3 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 EDK41188.1 - 0.0081 15.7 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain SIS_2 PF13580.1 EDK41188.1 - 0.23 11.1 3.6 0.29 10.8 0.2 2.5 2 1 1 3 3 3 0 SIS domain ADH_zinc_N PF00107.21 EDK41189.2 - 1e-26 93.0 0.1 1.6e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK41189.2 - 0.00016 22.6 0.0 0.00043 21.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PGM_PMM_II PF02879.11 EDK41189.2 - 0.013 15.8 0.1 0.035 14.4 0.1 1.8 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II AlaDh_PNT_C PF01262.16 EDK41189.2 - 0.064 12.8 0.1 0.099 12.2 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SIS_2 PF13580.1 EDK41189.2 - 0.12 12.1 1.9 0.24 11.1 0.3 2.2 2 1 1 3 3 3 0 SIS domain TusA PF01206.12 EDK41189.2 - 0.12 11.9 0.0 4.2 7.0 0.0 2.5 1 1 1 2 2 2 0 Sulfurtransferase TusA ADH_zinc_N PF00107.21 EDK41190.1 - 0.0013 18.2 1.0 0.0021 17.5 0.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SIS_2 PF13580.1 EDK41190.1 - 0.011 15.4 0.1 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 SIS domain CDC50 PF03381.10 EDK41191.2 - 1.4e-95 319.6 3.9 1.9e-95 319.2 2.7 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family eRF1_2 PF03464.10 EDK41192.1 - 5e-46 156.3 0.1 9.2e-46 155.4 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 EDK41192.1 - 1.8e-36 124.8 0.2 3.8e-36 123.7 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 EDK41192.1 - 1.5e-27 95.7 0.1 3e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 PTSIIB_sorb PF03830.10 EDK41192.1 - 0.068 13.0 0.6 0.15 11.8 0.1 1.9 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component Ribosomal_L7Ae PF01248.21 EDK41192.1 - 0.079 12.4 0.0 0.24 10.9 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2969 PF11184.3 EDK41192.1 - 0.55 10.3 3.3 22 5.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2969) DEAD PF00270.24 EDK41193.1 - 3.6e-39 133.9 0.0 8e-39 132.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK41193.1 - 1.4e-22 79.3 0.0 3.8e-22 77.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK41193.1 - 0.00016 21.5 2.5 0.00024 20.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EDK41193.1 - 0.008 16.3 1.7 0.023 14.8 0.1 2.4 2 1 0 2 2 2 1 AAA domain DUF3321 PF11968.3 EDK41194.2 - 2.3e-92 308.5 0.2 4.8e-92 307.5 0.1 1.5 2 0 0 2 2 2 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 EDK41194.2 - 9e-08 32.0 0.0 1.6e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK41194.2 - 0.0091 16.4 0.0 0.061 13.8 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain FliG_M PF14841.1 EDK41194.2 - 0.12 12.3 0.1 0.84 9.6 0.0 2.3 2 0 0 2 2 2 0 FliG middle domain Sugar_tr PF00083.19 EDK41195.2 - 4.6e-160 533.0 28.7 5.3e-160 532.8 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41195.2 - 1.8e-32 112.4 24.8 3.1e-28 98.5 9.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK41195.2 - 0.0002 19.6 0.6 0.0002 19.6 0.4 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cytochrom_B_N PF00033.14 EDK41195.2 - 0.0081 15.5 5.2 0.012 15.0 0.8 2.8 3 0 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 EDK41195.2 - 0.083 12.2 6.5 0.5 9.7 2.2 3.0 3 1 0 3 3 3 0 Prokaryotic cytochrome b561 Aminotran_1_2 PF00155.16 EDK41196.1 - 4.9e-80 269.1 0.0 5.6e-80 268.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PGM_PMM_I PF02878.11 EDK41197.2 - 2.4e-37 127.5 0.2 3.4e-37 127.0 0.1 1.2 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 EDK41197.2 - 5.7e-23 81.1 0.0 1.7e-22 79.6 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 EDK41197.2 - 1.8e-14 53.9 0.1 4.6e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 EDK41197.2 - 1.3e-10 41.1 0.0 3.2e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain GATA PF00320.22 EDK41198.2 - 6.3e-15 54.2 4.0 1.8e-14 52.7 2.7 1.9 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 EDK41198.2 - 0.0071 15.6 0.3 0.013 14.8 0.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Ribosomal_S15 PF00312.17 EDK41199.2 - 8.4e-18 63.9 0.1 8.4e-18 63.9 0.1 3.0 3 0 0 3 3 3 1 Ribosomal protein S15 DUF2175 PF09943.4 EDK41199.2 - 0.4 10.7 4.5 0.82 9.7 0.3 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Nnf1 PF03980.9 EDK41200.2 - 1.7e-32 111.6 1.7 3e-32 110.8 1.2 1.4 1 0 0 1 1 1 1 Nnf1 Atg31 PF09795.4 EDK41200.2 - 0.0057 16.3 7.0 0.073 12.7 0.5 2.6 2 1 1 3 3 3 2 Autophagy-related protein 31 Vps53_N PF04100.7 EDK41200.2 - 0.01 14.6 3.8 0.057 12.1 0.1 2.1 2 0 0 2 2 2 0 Vps53-like, N-terminal HALZ PF02183.13 EDK41200.2 - 0.11 12.1 0.7 0.39 10.4 0.1 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper SNAP PF14938.1 EDK41201.2 - 2.5e-108 361.5 8.1 2.8e-108 361.3 5.6 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 EDK41201.2 - 1.3e-11 44.2 7.3 2.3e-07 30.6 0.4 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 EDK41201.2 - 6.1e-09 35.4 10.3 4.6e-06 26.1 0.8 3.6 1 1 3 4 4 4 4 TPR repeat TPR_2 PF07719.12 EDK41201.2 - 4.2e-08 32.5 8.0 0.043 13.7 0.2 5.3 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 EDK41201.2 - 5.6e-08 32.0 3.3 0.0042 16.7 0.1 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 EDK41201.2 - 9.7e-07 29.3 0.3 0.0029 18.2 0.0 3.5 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 EDK41201.2 - 3.9e-06 27.0 0.9 0.82 10.4 0.0 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 EDK41201.2 - 2.4e-05 23.7 11.4 0.26 10.9 0.0 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 EDK41201.2 - 3.2e-05 24.0 3.9 0.038 14.4 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 EDK41201.2 - 4.7e-05 22.8 8.8 0.005 16.5 0.0 4.3 4 1 0 4 4 3 2 Tetratricopeptide repeat Apc3 PF12895.2 EDK41201.2 - 0.0001 22.3 9.8 0.011 15.8 1.7 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.4 EDK41201.2 - 0.001 18.4 1.1 0.13 11.6 0.0 3.2 1 1 2 3 3 3 1 26S proteasome subunit RPN7 DUF2225 PF09986.4 EDK41201.2 - 0.038 13.4 4.2 0.24 10.8 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF3206 PF11472.3 EDK41201.2 - 0.044 13.5 0.4 0.13 12.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) TPR_19 PF14559.1 EDK41201.2 - 0.051 13.9 3.4 4.9 7.5 0.0 3.2 2 2 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 EDK41201.2 - 0.052 13.7 2.9 10 6.5 0.1 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 EDK41201.2 - 0.07 13.6 15.1 1.5 9.7 0.1 6.2 7 0 0 7 7 5 0 Aromatic-di-Alanine (AdAR) repeat Foie-gras_1 PF11817.3 EDK41201.2 - 0.094 12.1 0.7 0.3 10.5 0.4 2.0 1 1 1 2 2 2 0 Foie gras liver health family 1 Rapamycin_bind PF08771.6 EDK41201.2 - 0.15 12.1 3.0 1.6 8.8 0.2 3.0 3 0 0 3 3 3 0 Rapamycin binding domain MIT PF04212.13 EDK41201.2 - 0.43 10.4 8.3 14 5.6 0.1 4.5 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain MFS_1 PF07690.11 EDK41202.2 - 4.9e-23 81.4 5.4 4.9e-23 81.4 3.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2207 PF09972.4 EDK41202.2 - 4.9 5.6 6.7 0.27 9.7 0.7 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) MFS_1 PF07690.11 EDK41203.2 - 4.2e-17 61.8 49.4 2.8e-09 36.1 12.1 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily CPSase_L_D2 PF02786.12 EDK41204.2 - 7.7e-23 80.8 0.0 1.1e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.1 EDK41204.2 - 6.2e-22 78.2 0.1 1.3e-21 77.1 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_chain PF00289.17 EDK41204.2 - 4.3e-17 62.2 0.0 8.5e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 EDK41204.2 - 1.2e-09 37.3 0.0 1.4e-08 33.8 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EDK41204.2 - 7.9e-09 35.0 0.0 1.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EDK41204.2 - 3.2e-08 33.1 0.0 6.8e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.6 EDK41204.2 - 1.4e-06 27.9 0.0 3.6e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 RimK-like ATP-grasp domain Epimerase PF01370.16 EDK41204.2 - 0.0013 18.2 0.0 0.0033 16.9 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GARS_A PF01071.14 EDK41204.2 - 0.017 14.6 0.1 0.032 13.7 0.1 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TrkA_N PF02254.13 EDK41204.2 - 0.022 14.7 0.0 0.074 13.0 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain CPSase_L_D2 PF02786.12 EDK41205.2 - 3.7e-85 284.5 0.0 8.9e-85 283.2 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 EDK41205.2 - 9.8e-17 61.0 0.0 2e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 EDK41205.2 - 2.1e-15 56.5 0.1 8.2e-15 54.6 0.0 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 EDK41205.2 - 1.6e-14 54.1 0.0 2.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 EDK41205.2 - 4.6e-14 51.9 0.0 2.8e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 EDK41205.2 - 7.2e-10 38.4 0.0 1.4e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 EDK41205.2 - 3.3e-07 29.9 0.0 6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.1 EDK41205.2 - 0.085 12.0 0.0 0.17 11.0 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.6 EDK41205.2 - 0.087 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain PIG-P PF08510.7 EDK41206.2 - 5.9e-38 129.3 6.8 6.7e-38 129.1 4.7 1.0 1 0 0 1 1 1 1 PIG-P YrhC PF14143.1 EDK41206.2 - 0.074 12.9 0.5 0.73 9.8 0.0 2.1 2 0 0 2 2 2 0 YrhC-like protein HEAT PF02985.17 EDK41207.2 - 9.3e-31 103.1 17.6 0.00017 21.3 0.0 11.6 11 0 0 11 11 11 7 HEAT repeat HEAT_EZ PF13513.1 EDK41207.2 - 3.3e-30 103.7 3.2 5.6e-11 42.5 0.0 9.6 8 2 3 11 11 9 5 HEAT-like repeat HEAT_2 PF13646.1 EDK41207.2 - 9.5e-30 102.7 0.8 3.6e-07 30.3 0.0 7.9 4 2 2 8 8 8 5 HEAT repeats Vac14_Fab1_bd PF12755.2 EDK41207.2 - 6.8e-11 42.4 1.1 0.0032 17.7 0.2 5.6 3 2 3 7 7 7 4 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 EDK41207.2 - 7.6e-10 38.9 9.8 0.032 14.0 0.3 6.3 4 3 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 EDK41207.2 - 1.3e-08 33.6 2.6 9e-07 27.5 0.2 3.5 3 1 0 3 3 3 1 Adaptin N terminal region Arm PF00514.18 EDK41207.2 - 9.2e-08 31.6 12.9 0.16 11.8 0.0 7.5 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat IBN_N PF03810.14 EDK41207.2 - 2.2e-07 30.7 5.3 0.0002 21.2 0.1 5.1 6 0 0 6 6 6 1 Importin-beta N-terminal domain Dopey_N PF04118.9 EDK41207.2 - 0.003 16.3 0.1 0.0085 14.8 0.1 1.7 1 0 0 1 1 1 1 Dopey, N-terminal HEAT_PBS PF03130.11 EDK41207.2 - 0.023 15.1 0.2 2.1e+02 2.8 0.0 5.4 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Xpo1 PF08389.7 EDK41207.2 - 0.025 14.5 9.0 0.049 13.5 0.5 4.9 5 2 0 5 5 5 0 Exportin 1-like protein DUF1981 PF09324.5 EDK41207.2 - 0.047 13.2 3.4 10 5.7 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) NOA36 PF06524.7 EDK41207.2 - 0.72 9.0 5.5 1.2 8.3 3.8 1.2 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.1 EDK41207.2 - 0.74 10.1 12.2 1.6 9.0 8.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SH3_1 PF00018.23 EDK41208.2 - 2.2e-07 30.1 1.9 4.1e-07 29.2 0.0 2.4 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.1 EDK41208.2 - 8.1e-05 22.1 0.9 0.014 14.9 0.1 3.2 3 0 0 3 3 3 2 Variant SH3 domain FTR1 PF03239.9 EDK41209.2 - 1.1e-75 254.4 8.7 1.3e-75 254.2 6.0 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family UPF0233 PF06781.7 EDK41209.2 - 0.05 13.2 1.0 0.2 11.3 0.7 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0233) E1_DerP2_DerF2 PF02221.10 EDK41210.2 - 3.3e-25 88.9 0.1 3.9e-25 88.6 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 EDK41210.2 - 0.063 13.3 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 ML-like domain Sulfate_transp PF00916.15 EDK41211.2 - 2.4e-46 157.9 4.2 4.6e-46 157.0 2.9 1.5 1 0 0 1 1 1 1 Sulfate transporter family STAS PF01740.16 EDK41211.2 - 3.9e-14 52.0 0.0 2.5e-12 46.2 0.0 2.4 2 0 0 2 2 2 1 STAS domain PCDO_beta_N PF12391.3 EDK41211.2 - 0.11 11.9 0.5 0.19 11.1 0.4 1.4 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal Cyc-maltodext_C PF10438.4 EDK41212.2 - 0.02 14.9 0.0 0.31 11.1 0.0 2.4 2 0 0 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain Pkinase PF00069.20 EDK41213.2 - 3e-42 144.5 0.0 4.9e-22 78.3 0.0 3.8 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41213.2 - 1.4e-15 57.1 0.0 1.8e-12 46.9 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.18 EDK41213.2 - 0.0028 17.4 0.0 0.0091 15.7 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EDK41213.2 - 0.044 12.7 0.0 0.67 8.8 0.0 2.1 1 1 0 1 1 1 0 Kinase-like Bot1p PF12298.3 EDK41214.1 - 5e-25 88.4 0.0 7.9e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein HTH_Tnp_1 PF01527.15 EDK41214.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Transposase Bot1p PF12298.3 EDK41215.2 - 3.1e-24 85.8 0.2 4.2e-24 85.4 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein EMP24_GP25L PF01105.19 EDK41216.2 - 6.6e-43 146.5 0.2 9e-43 146.1 0.2 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RNA_pol_A_bac PF01000.21 EDK41218.2 - 8.3e-31 106.4 0.0 1.5e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EDK41218.2 - 4e-16 57.8 0.0 6.4e-16 57.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Hormone_4 PF00220.12 EDK41218.2 - 0.13 11.9 1.0 0.38 10.5 0.7 1.8 1 0 0 1 1 1 0 Neurohypophysial hormones, N-terminal Domain DUF1746 PF08508.5 EDK41219.2 - 4.5e-16 58.8 2.8 7e-16 58.2 2.0 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Prenyltrans PF00432.16 EDK41220.2 - 1.9e-26 91.2 7.3 9.1e-11 41.1 0.1 4.7 4 1 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 EDK41220.2 - 5.5e-23 81.5 0.0 2.9e-16 59.8 0.0 4.7 2 1 2 4 4 4 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 EDK41220.2 - 5.4e-21 74.6 0.0 2.5e-11 43.5 0.0 5.3 4 2 1 5 5 5 3 Prenyltransferase-like Pec_lyase PF09492.5 EDK41220.2 - 3.8e-07 29.5 0.9 0.026 13.7 0.3 4.3 4 1 1 5 5 5 2 Pectic acid lyase A2M_comp PF07678.9 EDK41220.2 - 0.089 12.0 0.0 3 7.0 0.0 2.7 2 1 1 3 3 3 0 A-macroglobulin complement component Nrap PF03813.9 EDK41221.2 - 0 1209.2 0.0 0 1208.9 0.0 1.1 1 0 0 1 1 1 1 Nrap protein Amidohydro_1 PF01979.15 EDK41223.2 - 9.5e-32 110.9 0.5 6.8e-16 58.8 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 EDK41223.2 - 1.9e-25 90.4 0.1 2e-14 54.2 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 EDK41223.2 - 5.2e-09 35.7 0.1 1.3e-08 34.5 0.1 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 EDK41223.2 - 7.4e-07 28.7 0.0 0.0022 17.2 0.0 2.5 2 0 0 2 2 2 2 Amidohydrolase family DHOase PF12890.2 EDK41223.2 - 0.11 12.1 0.0 4.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Dihydro-orotase-like ADH_zinc_N PF00107.21 EDK41224.2 - 3.2e-11 42.8 0.0 7.4e-11 41.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK41224.2 - 8.5e-07 29.9 0.0 2e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK41224.2 - 0.00027 20.6 0.1 0.00089 18.9 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Mpv17_PMP22 PF04117.7 EDK41225.2 - 1.1e-07 31.3 0.3 3.5e-07 29.7 0.2 1.8 1 0 0 1 1 1 1 Mpv17 / PMP22 family Ycf4 PF02392.11 EDK41225.2 - 1.9 7.8 4.6 0.45 9.8 0.3 1.8 1 1 1 2 2 2 0 Ycf4 Sugar_tr PF00083.19 EDK41226.2 - 2.6e-88 296.5 29.2 3.1e-88 296.3 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41226.2 - 3.4e-16 58.8 32.3 3.4e-16 58.8 22.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 EDK41226.2 - 1.4 6.8 7.7 2.3 6.2 1.8 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector ArfGap PF01412.13 EDK41228.2 - 9e-33 112.5 1.1 2.4e-32 111.1 0.7 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ORC6 PF05460.8 EDK41228.2 - 5.5 5.9 14.2 8.4 5.3 9.9 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Tim44 PF04280.10 EDK41229.1 - 2.8e-33 114.9 0.6 5.7e-33 113.9 0.1 1.8 2 0 0 2 2 2 1 Tim44-like domain FAD_binding_3 PF01494.14 EDK41230.2 - 4.3e-20 72.0 0.0 2.4e-19 69.6 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 EDK41230.2 - 5.4e-06 26.3 0.0 1.3e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 EDK41230.2 - 1e-05 25.8 0.2 0.00043 20.6 0.0 2.9 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EDK41230.2 - 0.00052 19.7 0.0 0.00085 19.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 EDK41230.2 - 0.00054 19.8 0.1 0.0015 18.4 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 EDK41230.2 - 0.00076 18.4 0.0 0.0014 17.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 EDK41230.2 - 0.0011 17.8 0.0 0.032 13.0 0.0 2.4 3 0 0 3 3 3 1 Squalene epoxidase GIDA PF01134.17 EDK41230.2 - 0.0013 17.7 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.2 EDK41230.2 - 0.0039 16.3 0.0 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK41230.2 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.9 EDK41230.2 - 0.024 13.1 0.0 0.34 9.3 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.19 EDK41230.2 - 0.035 12.9 0.1 0.051 12.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.11 EDK41230.2 - 0.17 11.3 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RabGAP-TBC PF00566.13 EDK41231.2 - 5.6e-06 25.9 5.6 5.6e-06 25.9 3.9 2.8 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Tropomyosin_1 PF12718.2 EDK41231.2 - 0.0032 17.3 22.2 0.0058 16.4 15.4 1.4 1 0 0 1 1 1 1 Tropomyosin like Atg14 PF10186.4 EDK41231.2 - 3.5 6.4 18.4 7.1 5.4 12.7 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Reo_sigmaC PF04582.7 EDK41231.2 - 6.2 5.8 7.9 29 3.6 5.0 1.9 1 1 0 1 1 1 0 Reovirus sigma C capsid protein IncA PF04156.9 EDK41231.2 - 6.5 6.3 20.7 5.8 6.4 8.6 2.3 1 1 1 2 2 2 0 IncA protein Syntaxin-6_N PF09177.6 EDK41231.2 - 8.1 6.9 12.8 8.1 6.9 1.0 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TMF_DNA_bd PF12329.3 EDK41231.2 - 8.8 6.2 27.5 7.7 6.4 5.2 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Peptidase_C48 PF02902.14 EDK41232.2 - 1e-28 100.4 2.0 1e-28 100.4 1.4 2.2 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain 4HBT PF03061.17 EDK41233.1 - 1e-06 28.7 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF3918 PF13056.1 EDK41233.1 - 0.042 13.1 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) HSP9_HSP12 PF04119.7 EDK41234.1 - 6.2e-24 83.8 3.7 7e-24 83.6 2.5 1.0 1 0 0 1 1 1 1 Heat shock protein 9/12 Thymidylat_synt PF00303.14 EDK41235.1 - 3.5e-119 396.7 0.0 4e-119 396.5 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase DASH_Dad2 PF08654.5 EDK41236.1 - 3.9e-35 119.9 0.7 4.9e-35 119.6 0.5 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 NPV_P10 PF05531.7 EDK41236.1 - 0.00091 19.4 1.4 0.0012 19.0 1.0 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.17 EDK41236.1 - 0.0019 18.1 2.1 0.0025 17.8 1.4 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DASH_Duo1 PF08651.5 EDK41236.1 - 0.0053 16.3 1.3 0.0076 15.8 0.9 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 IncA PF04156.9 EDK41236.1 - 0.0069 15.9 1.0 0.0087 15.6 0.7 1.1 1 0 0 1 1 1 1 IncA protein CENP-F_leu_zip PF10473.4 EDK41236.1 - 0.012 15.4 2.3 0.015 15.1 1.6 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliD_N PF02465.13 EDK41236.1 - 0.05 13.9 1.0 0.066 13.5 0.7 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus BRX_N PF13713.1 EDK41236.1 - 0.057 12.8 0.2 0.16 11.4 0.1 1.7 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain SpoOE-like PF09388.5 EDK41236.1 - 0.062 12.8 2.6 0.091 12.2 1.1 1.8 1 1 1 2 2 2 0 Spo0E like sporulation regulatory protein EFG_C PF00679.19 EDK41236.1 - 0.083 12.7 0.0 0.19 11.5 0.0 1.7 1 1 0 1 1 1 0 Elongation factor G C-terminus IFT57 PF10498.4 EDK41236.1 - 0.083 11.6 1.7 0.11 11.2 1.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 M PF02370.11 EDK41236.1 - 2 9.0 5.4 1.1 9.8 0.2 2.5 2 0 0 2 2 2 0 M protein repeat Shugoshin_N PF07558.6 EDK41237.2 - 4.3e-13 48.7 6.4 4.3e-13 48.7 4.4 2.6 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 EDK41237.2 - 8e-09 34.8 8.5 8e-09 34.8 5.9 2.2 2 0 0 2 2 2 1 Shugoshin C terminus TSC22 PF01166.13 EDK41237.2 - 0.051 13.5 1.1 0.36 10.8 0.9 2.3 2 1 1 3 3 3 0 TSC-22/dip/bun family Acyl-thio_N PF12590.3 EDK41237.2 - 0.65 10.4 9.8 0.065 13.7 2.3 2.5 2 0 0 2 2 2 0 Acyl-ATP thioesterase Nucleoporin_C PF03177.9 EDK41238.2 - 6.1e-96 322.2 24.6 7.5e-96 321.9 17.1 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 EDK41238.2 - 9.8e-68 228.8 0.6 9.8e-68 228.8 0.4 2.2 2 0 0 2 2 2 1 Nup133 N terminal like Brix PF04427.13 EDK41239.2 - 2e-34 118.9 2.6 2.6e-34 118.5 1.8 1.1 1 0 0 1 1 1 1 Brix domain FAD_binding_8 PF08022.7 EDK41240.2 - 4.8e-22 77.8 0.1 1.6e-21 76.1 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.7 EDK41240.2 - 8.7e-20 71.2 0.0 1.4e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EDK41240.2 - 1.1e-14 54.5 15.7 2.5e-14 53.4 9.7 2.4 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.16 EDK41240.2 - 0.021 15.3 0.0 1.8 9.1 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain PrgI PF12666.2 EDK41240.2 - 2.3 8.4 7.5 2.8 8.1 3.3 2.5 2 1 0 2 2 2 0 PrgI family protein MaoC_dehydratas PF01575.14 EDK41241.2 - 2.8e-09 36.3 0.0 1.8e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 MaoC like domain Sugar_tr PF00083.19 EDK41242.2 - 1.8e-88 297.0 22.0 2.2e-88 296.8 15.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41242.2 - 3.6e-28 98.2 27.0 3.5e-19 68.7 4.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 EDK41242.2 - 0.00013 20.3 2.9 0.00026 19.3 2.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1228 PF06779.9 EDK41242.2 - 0.0039 17.1 10.2 0.05 13.6 0.7 3.6 4 1 1 5 5 5 2 Protein of unknown function (DUF1228) OATP PF03137.15 EDK41242.2 - 0.018 13.1 10.0 0.028 12.4 0.1 2.9 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3100 PF11299.3 EDK41242.2 - 0.55 9.4 5.6 2.2 7.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3100) ParBc PF02195.13 EDK41243.1 - 2.7e-14 53.0 0.0 3.4e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain FAD_binding_8 PF08022.7 EDK41244.2 - 7e-24 83.7 0.0 1.5e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 EDK41244.2 - 2.6e-22 79.3 0.0 4e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 EDK41244.2 - 8e-16 58.2 11.5 3.8e-15 56.0 7.0 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component Phage-tail_3 PF13550.1 EDK41244.2 - 0.067 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative phage tail protein FTR1 PF03239.9 EDK41245.2 - 3.7e-82 275.7 0.7 2.9e-80 269.4 0.5 2.0 1 1 0 1 1 1 1 Iron permease FTR1 family Acetate_kinase PF00871.12 EDK41245.2 - 0.065 11.7 0.0 0.097 11.1 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family DUF897 PF05982.7 EDK41245.2 - 0.39 9.4 9.3 0.57 8.9 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF897) Tmemb_14 PF03647.8 EDK41245.2 - 0.46 10.9 7.8 4.3 7.8 0.7 2.8 2 0 0 2 2 2 0 Transmembrane proteins 14C UPF0016 PF01169.14 EDK41245.2 - 0.93 9.6 7.0 2.2 8.4 1.0 2.8 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 HlyIII PF03006.15 EDK41245.2 - 1.1 8.6 8.5 4.3 6.6 0.1 3.0 3 0 0 3 3 3 0 Haemolysin-III related Pkinase PF00069.20 EDK41246.2 - 2e-63 213.9 0.0 2.5e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41246.2 - 1.7e-31 109.2 0.0 2.5e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK41246.2 - 0.0072 15.3 0.2 0.018 13.9 0.0 1.7 2 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 EDK41246.2 - 0.011 14.5 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 EDK41246.2 - 0.13 11.2 0.3 0.96 8.4 0.2 2.2 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sugar_tr PF00083.19 EDK41247.1 - 1.7e-112 376.2 36.4 2e-112 376.0 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41247.1 - 4.9e-27 94.5 43.5 3.1e-26 91.9 21.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cytochrom_C1 PF02167.10 EDK41248.1 - 5.8e-83 277.8 0.0 6.9e-83 277.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 EDK41248.1 - 0.0046 17.0 0.1 0.0094 16.0 0.1 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 EDK41248.1 - 0.033 15.0 0.1 0.096 13.5 0.1 1.8 1 0 0 1 1 1 0 Cytochrome c DUF2340 PF10209.4 EDK41249.1 - 3.6e-54 182.1 0.8 4.2e-54 181.9 0.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF4177 PF13783.1 EDK41249.1 - 0.012 15.2 0.1 0.042 13.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4177) CH PF00307.26 EDK41250.2 - 6.1e-22 77.7 10.0 2.9e-16 59.4 0.1 4.2 3 2 1 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 EDK41250.2 - 0.04 13.5 4.0 0.081 12.5 0.0 3.4 4 1 0 4 4 4 0 CAMSAP CH domain NHR2 PF08788.6 EDK41250.2 - 0.042 13.3 0.4 0.28 10.6 0.0 2.4 2 0 0 2 2 2 0 NHR2 domain like DUF2203 PF09969.4 EDK41250.2 - 0.043 14.0 0.3 2.4 8.3 0.0 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Pkinase PF00069.20 EDK41251.2 - 6.4e-54 182.8 0.0 7.9e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41251.2 - 5.8e-18 64.8 0.0 9.3e-17 60.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 EDK41251.2 - 4.6e-06 26.5 0.0 2.8e-05 23.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 EDK41251.2 - 0.011 14.6 0.0 0.022 13.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.15 EDK41251.2 - 0.021 14.4 0.1 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 EDK41251.2 - 0.072 12.4 0.2 7.6 5.8 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Ribosomal_L18e PF00828.14 EDK41253.1 - 2.5e-16 60.2 0.0 5.1e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 DUF3128 PF11326.3 EDK41254.2 - 2.7e-32 110.7 1.0 3.6e-32 110.3 0.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3128) Ras PF00071.17 EDK41255.1 - 4.2e-22 78.2 0.0 4.9e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Plasmodium_Vir PF05795.6 EDK41256.2 - 0.075 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Glyco_transf_8 PF01501.15 EDK41257.2 - 0.00032 20.1 0.6 0.0041 16.4 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 8 Tho2 PF11262.3 EDK41258.2 - 1.2e-77 260.9 3.9 1.2e-77 260.9 2.7 3.5 4 0 0 4 4 4 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 EDK41258.2 - 7.8e-30 102.4 0.7 3.8e-29 100.2 0.1 2.5 2 0 0 2 2 2 1 Transcription- and export-related complex subunit zf-C2H2 PF00096.21 EDK41259.2 - 7.6e-25 85.7 69.4 4.3e-05 23.6 0.1 9.3 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK41259.2 - 1.4e-17 62.6 62.3 0.0076 16.5 0.4 9.3 9 0 0 9 9 9 7 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK41259.2 - 1.3e-12 47.3 71.1 8.6e-07 28.9 0.4 10.4 10 1 1 11 11 11 5 Zinc-finger double domain zf-met PF12874.2 EDK41259.2 - 0.0011 19.1 38.5 0.34 11.1 0.1 8.0 9 0 0 9 9 9 4 Zinc-finger of C2H2 type IBR PF01485.16 EDK41259.2 - 0.0041 16.9 1.1 0.0041 16.9 0.7 5.1 2 1 2 4 4 4 2 IBR domain zf-C2H2_jaz PF12171.3 EDK41259.2 - 0.67 10.1 44.5 0.65 10.2 0.2 8.8 8 2 1 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 EDK41259.2 - 0.76 9.7 26.3 0.71 9.8 0.6 6.4 6 0 0 6 6 6 0 C2H2-type zinc finger zinc_ribbon_5 PF13719.1 EDK41259.2 - 5 6.7 9.8 4.2 7.0 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 EDK41259.2 - 5.2 6.8 9.9 5.3 6.8 0.1 3.7 3 0 0 3 3 3 0 zinc-ribbon domain NADH-G_4Fe-4S_3 PF10588.4 EDK41259.2 - 5.5 6.3 8.0 3 7.1 0.2 3.3 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region hDGE_amylase PF14701.1 EDK41260.2 - 2.6e-169 563.6 0.0 3.4e-169 563.2 0.0 1.2 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme hGDE_central PF14702.1 EDK41260.2 - 1.9e-48 164.9 0.0 3e-48 164.2 0.0 1.3 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 EDK41260.2 - 9.5e-28 95.8 0.7 2.2e-27 94.7 0.5 1.7 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 EDK41260.2 - 1.5e-06 27.8 0.1 0.00037 19.9 0.1 2.3 2 0 0 2 2 2 2 Alpha amylase, catalytic domain DUF4038 PF13204.1 EDK41260.2 - 0.078 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) SRP72 PF08492.7 EDK41261.2 - 8e-10 38.9 1.7 8e-10 38.9 1.2 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.1 EDK41261.2 - 0.014 15.6 8.5 5.9 7.3 1.7 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 EDK41261.2 - 0.07 13.6 0.2 12 6.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 EDK41261.2 - 0.11 12.4 1.2 9.2 6.2 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Aldedh PF00171.17 EDK41262.2 - 8.2e-77 258.4 0.5 1e-76 258.1 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ECH PF00378.15 EDK41262.2 - 0.054 12.6 0.6 0.17 10.9 0.2 1.9 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase family Hap4_Hap_bind PF10297.4 EDK41264.2 - 2e-07 30.5 10.5 2e-07 30.5 7.3 1.7 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 DUF4515 PF14988.1 EDK41264.2 - 0.067 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) FGGY_N PF00370.16 EDK41265.2 - 1.9e-17 63.4 0.0 1.6e-09 37.4 0.0 3.1 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 EDK41265.2 - 1.1e-12 47.9 0.0 1.6e-11 44.2 0.0 2.6 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain AlaDh_PNT_N PF05222.10 EDK41267.1 - 1.6e-27 96.1 0.0 3e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 EDK41267.1 - 2.4e-18 66.2 0.0 3.7e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain WD40 PF00400.27 EDK41268.1 - 4.2e-34 115.2 3.3 3.1e-09 36.3 0.1 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 EDK41268.1 - 9.1e-10 37.2 0.7 0.00063 18.0 0.0 2.7 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 EDK41268.1 - 1e-06 27.8 3.5 0.92 8.1 0.0 4.7 1 1 4 5 5 5 3 Nup133 N terminal like BBS2_Mid PF14783.1 EDK41268.1 - 0.0015 18.2 0.6 3.1 7.6 0.0 4.3 2 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Hira PF07569.6 EDK41268.1 - 0.0058 15.8 0.2 0.36 10.0 0.0 2.7 2 0 0 2 2 2 1 TUP1-like enhancer of split DUF2793 PF10983.3 EDK41268.1 - 0.033 13.9 0.3 13 5.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2793) CobW_C PF07683.9 EDK41268.1 - 0.072 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain LigT_PEase PF02834.11 EDK41269.2 - 6.5e-08 32.4 0.2 0.0042 17.0 0.0 2.3 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.1 EDK41269.2 - 0.00018 21.2 0.8 0.00063 19.4 0.6 1.7 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily 2H-phosphodiest PF08975.5 EDK41269.2 - 0.0065 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1868) HVSL PF09749.4 EDK41269.2 - 0.016 14.2 1.3 0.18 10.8 0.9 2.0 1 1 0 1 1 1 0 Uncharacterised conserved protein CPDase PF07823.6 EDK41269.2 - 0.065 12.7 1.7 2.2 7.7 0.0 2.1 1 1 1 2 2 2 0 Cyclic phosphodiesterase-like protein DUF3932 PF13068.1 EDK41269.2 - 0.097 12.7 0.3 0.3 11.2 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3932) Dabb PF07876.7 EDK41269.2 - 0.2 12.0 1.8 4.2 7.8 0.0 2.7 3 0 0 3 3 3 0 Stress responsive A/B Barrel Domain TPR_2 PF07719.12 EDK41270.2 - 1e-35 118.7 19.6 7.3e-06 25.5 0.1 11.6 13 0 0 13 13 13 7 Tetratricopeptide repeat TPR_11 PF13414.1 EDK41270.2 - 5.9e-35 118.7 20.3 1.3e-09 37.5 0.0 7.0 7 0 0 7 7 7 5 TPR repeat TPR_1 PF00515.23 EDK41270.2 - 2.2e-34 115.6 10.9 2.4e-06 26.9 0.2 10.1 10 0 0 10 10 10 6 Tetratricopeptide repeat Apc3 PF12895.2 EDK41270.2 - 9.3e-24 83.3 20.2 2.7e-19 69.0 0.3 5.7 4 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 EDK41270.2 - 9.4e-24 83.1 11.5 4.4e-12 45.7 0.4 9.1 6 2 5 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.1 EDK41270.2 - 1.7e-23 82.6 4.2 0.00025 21.6 0.0 7.7 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 EDK41270.2 - 1e-21 75.0 10.1 1.7e-05 24.2 0.6 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 EDK41270.2 - 8.7e-19 67.6 11.4 0.0049 17.1 0.1 7.4 6 2 1 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 EDK41270.2 - 6.2e-17 60.5 6.0 0.64 10.8 0.0 9.7 5 1 5 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 EDK41270.2 - 5.8e-15 53.8 9.8 0.0062 16.2 0.0 8.4 8 1 0 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.1 EDK41270.2 - 9.7e-10 38.0 12.5 0.0066 16.3 0.4 7.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 EDK41270.2 - 1.7e-09 37.4 7.7 3.7e-05 23.4 0.0 5.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.1 EDK41270.2 - 1.8e-08 33.9 17.5 0.45 10.8 0.0 8.9 11 0 0 11 11 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 EDK41270.2 - 3.7e-08 33.2 9.3 0.76 10.3 0.1 8.5 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.1 EDK41270.2 - 0.0011 18.0 5.9 0.54 9.2 0.0 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.4 EDK41270.2 - 3 7.7 8.9 3.8 7.4 0.0 4.5 5 1 0 5 5 4 0 Tetratricopeptide repeat WD40 PF00400.27 EDK41271.2 - 3.3e-06 26.7 6.0 0.00031 20.5 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat BRAP2 PF07576.7 EDK41272.2 - 0.036 13.6 0.1 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 BRCA1-associated protein 2 PUF PF00806.14 EDK41273.2 - 1.9e-59 193.9 15.0 5.3e-08 31.9 0.0 8.7 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat SapB_2 PF03489.12 EDK41273.2 - 0.12 12.4 0.1 3 7.9 0.0 2.9 2 0 0 2 2 2 0 Saposin-like type B, region 2 SIS PF01380.17 EDK41274.2 - 5.8e-13 48.5 0.0 1.3e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 EDK41274.2 - 0.00059 19.5 0.1 0.047 13.3 0.0 2.5 1 1 1 2 2 2 2 SIS domain KaiA PF07688.7 EDK41274.2 - 0.00099 18.4 0.0 0.0019 17.5 0.0 1.5 1 0 0 1 1 1 1 KaiA domain DUF3384 PF11864.3 EDK41275.2 - 7.5e-88 295.0 10.7 1.9e-87 293.7 7.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.10 EDK41275.2 - 1.9e-59 200.1 5.1 8.5e-59 198.0 1.7 2.4 2 0 0 2 2 2 1 Rap/ran-GAP Tuberin PF03542.11 EDK41275.2 - 1.2e-22 80.5 5.1 3.7e-21 75.5 2.8 2.7 2 1 0 2 2 2 1 Tuberin AA_permease PF00324.16 EDK41276.2 - 3.8e-138 460.8 41.5 4.3e-138 460.6 28.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK41276.2 - 1.2e-41 142.6 42.3 1.5e-41 142.3 29.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF946 PF06101.6 EDK41277.1 - 6.5e-12 44.2 0.5 1.2e-11 43.3 0.3 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF946) NAD_binding_1 PF00175.16 EDK41278.1 - 8.2e-31 106.8 0.0 1.3e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EDK41278.1 - 4.6e-30 103.6 0.0 6.8e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EDK41278.1 - 0.00045 20.1 0.0 0.0049 16.7 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Ofd1_CTDD PF10637.4 EDK41279.2 - 3.5e-94 314.8 0.6 5.1e-91 304.5 0.1 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 EDK41279.2 - 5.6e-14 52.4 0.1 2.1e-13 50.6 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily AA_kinase PF00696.23 EDK41280.2 - 1.9e-39 135.6 0.0 2.9e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 EDK41280.2 - 1.2e-09 37.3 1.2 1e-05 24.8 0.4 2.6 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 EDK41280.2 - 1.4e-06 27.7 2.8 7e-05 22.2 0.4 2.4 2 0 0 2 2 2 2 ACT domain BAR_2 PF10455.4 EDK41281.2 - 1.8e-65 220.7 7.7 2.5e-65 220.2 5.3 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 EDK41281.2 - 7.1e-17 61.6 4.3 4.1e-16 59.1 3.0 2.0 1 1 0 1 1 1 1 BAR domain DUF310 PF03750.8 EDK41281.2 - 0.00035 20.7 1.6 0.0009 19.4 0.2 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF310) Arfaptin PF06456.8 EDK41281.2 - 0.0011 18.3 2.0 0.038 13.3 0.1 2.5 1 1 1 2 2 2 1 Arfaptin-like domain SBDS_C PF09377.5 EDK41281.2 - 0.0027 17.3 0.0 0.0078 15.9 0.0 1.7 1 1 0 1 1 1 1 SBDS protein C-terminal domain UPF0236 PF06782.6 EDK41281.2 - 0.0078 14.6 0.9 0.018 13.4 0.6 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0236) Frataxin_Cyay PF01491.11 EDK41281.2 - 0.19 11.5 2.8 1.3 8.8 0.1 2.9 3 0 0 3 3 3 0 Frataxin-like domain Aminotran_1_2 PF00155.16 EDK41282.2 - 1.1e-23 83.8 0.0 1.5e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 EDK41282.2 - 0.0011 17.5 0.0 0.017 13.7 0.0 2.3 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Tubulin PF00091.20 EDK41283.2 - 7.7e-46 156.6 0.1 1.1e-45 156.0 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 EDK41283.2 - 3.1e-12 46.6 0.0 4.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 EDK41283.2 - 0.0048 16.3 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain adh_short PF00106.20 EDK41284.2 - 2e-19 70.1 0.0 2.6e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41284.2 - 2.4e-17 63.5 0.0 2.9e-17 63.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41284.2 - 1.3e-08 34.7 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK41284.2 - 1.8e-05 24.2 0.0 3e-05 23.5 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EDK41284.2 - 0.0023 17.9 0.0 0.005 16.8 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding PAC2 PF09754.4 EDK41284.2 - 0.0023 17.8 0.0 0.006 16.4 0.0 1.7 2 0 0 2 2 2 1 PAC2 family PdxJ PF03740.8 EDK41284.2 - 0.0047 16.1 0.0 0.0086 15.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthesis protein PdxJ F420_oxidored PF03807.12 EDK41284.2 - 0.066 13.6 0.0 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent G6PD_N PF00479.17 EDK41284.2 - 0.11 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 EDK41284.2 - 0.12 11.2 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase adh_short PF00106.20 EDK41285.2 - 3e-21 76.0 0.0 4.2e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41285.2 - 1.5e-17 64.1 0.0 1.8e-17 63.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41285.2 - 4.5e-10 39.4 0.0 7.3e-10 38.7 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK41285.2 - 1.1e-05 24.9 0.0 1.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 EDK41285.2 - 0.00071 19.6 0.0 0.001 19.1 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding PAC2 PF09754.4 EDK41285.2 - 0.0058 16.5 0.0 0.0092 15.8 0.0 1.3 1 0 0 1 1 1 1 PAC2 family Fungal_trans PF04082.13 EDK41286.2 - 4.8e-27 94.4 0.2 1e-26 93.3 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41286.2 - 1.1e-05 25.2 12.1 2.8e-05 23.9 8.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.8 EDK41286.2 - 0.037 13.9 0.2 0.08 12.8 0.1 1.6 1 0 0 1 1 1 0 Gal4-like dimerisation domain Dickkopf_N PF04706.7 EDK41286.2 - 3.6 7.8 15.0 17 5.7 10.4 2.0 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region adh_short PF00106.20 EDK41287.1 - 1.3e-32 113.0 0.5 1.9e-32 112.4 0.4 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41287.1 - 1.9e-22 80.1 0.0 2.5e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41287.1 - 5.1e-16 58.8 0.2 8.1e-16 58.1 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK41287.1 - 0.00029 20.3 0.1 0.00038 19.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 EDK41287.1 - 0.0031 17.2 0.2 0.0078 15.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Transketolase_N PF00456.16 EDK41287.1 - 0.036 12.8 0.1 0.064 12.0 0.1 1.3 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain Spermine_synth PF01564.12 EDK41287.1 - 0.051 12.5 0.2 0.076 11.9 0.1 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase PRK PF00485.13 EDK41288.2 - 3.9e-09 36.3 0.0 5e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 EDK41288.2 - 4.9e-08 33.8 0.0 1.3e-07 32.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 EDK41288.2 - 3.9e-07 30.4 0.2 4.7e-06 26.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 EDK41288.2 - 1.1e-05 25.2 0.0 0.0023 17.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 EDK41288.2 - 1.2e-05 24.4 0.0 1.9e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Zeta_toxin PF06414.7 EDK41288.2 - 2.2e-05 23.6 0.0 4.8e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin 6PF2K PF01591.13 EDK41288.2 - 6.1e-05 22.2 0.0 0.00012 21.2 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase KTI12 PF08433.5 EDK41288.2 - 6.7e-05 22.2 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_19 PF13245.1 EDK41288.2 - 0.0002 21.0 0.0 0.00074 19.2 0.0 1.9 2 0 0 2 2 2 1 Part of AAA domain NB-ARC PF00931.17 EDK41288.2 - 0.00045 19.1 0.0 0.00064 18.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.17 EDK41288.2 - 0.0011 18.5 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain APS_kinase PF01583.15 EDK41288.2 - 0.0038 16.8 0.0 0.0083 15.7 0.0 1.6 2 0 0 2 2 1 1 Adenylylsulphate kinase MMR_HSR1 PF01926.18 EDK41288.2 - 0.0046 16.9 0.1 0.0097 15.8 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.11 EDK41288.2 - 0.0083 14.9 0.0 0.012 14.3 0.0 1.2 1 0 0 1 1 1 1 ArgK protein T2SE PF00437.15 EDK41288.2 - 0.015 14.1 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.24 EDK41288.2 - 0.018 15.2 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 EDK41288.2 - 0.02 14.6 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EDK41288.2 - 0.022 14.7 0.0 0.036 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.12 EDK41288.2 - 0.023 14.2 0.2 0.037 13.5 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.13 EDK41288.2 - 0.026 14.0 0.0 0.046 13.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 EDK41288.2 - 0.033 14.4 0.0 0.062 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.16 EDK41288.2 - 0.041 13.0 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 EDK41288.2 - 0.049 13.0 0.1 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 EDK41288.2 - 0.051 13.7 0.0 0.094 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.7 EDK41288.2 - 0.052 12.5 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus CoaE PF01121.15 EDK41288.2 - 0.057 12.8 0.2 0.74 9.1 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase NTPase_1 PF03266.10 EDK41288.2 - 0.065 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 NTPase cobW PF02492.14 EDK41288.2 - 0.075 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.13 EDK41288.2 - 0.091 12.0 0.1 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_PrkA PF08298.6 EDK41288.2 - 0.12 11.0 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain NACHT PF05729.7 EDK41288.2 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.1 EDK41288.2 - 0.13 11.7 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 EDK41288.2 - 0.14 11.7 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.1 EDK41288.2 - 0.14 12.0 0.8 15 5.4 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase-like family ADH_N PF08240.7 EDK41289.1 - 1.7e-30 105.0 1.4 3e-30 104.1 0.6 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK41289.1 - 1.4e-17 63.4 0.1 2.5e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 EDK41289.1 - 0.00023 22.0 0.0 0.0004 21.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.1 EDK41289.1 - 0.00059 19.4 0.1 0.001 18.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK41289.1 - 0.0011 19.4 0.1 0.0021 18.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK41289.1 - 0.02 15.3 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 EDK41289.1 - 0.055 12.5 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 EDK41289.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.20 EDK41290.1 - 1.1e-30 106.7 1.9 1.3e-30 106.5 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41290.1 - 7.1e-22 78.3 0.0 9.1e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41290.1 - 7.8e-14 51.7 0.8 1.1e-13 51.2 0.6 1.1 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.8 EDK41290.1 - 0.033 13.5 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family RmlD_sub_bind PF04321.12 EDK41290.1 - 0.065 12.1 0.8 5.9 5.6 0.1 2.4 1 1 0 2 2 2 0 RmlD substrate binding domain NmrA PF05368.8 EDK41290.1 - 0.094 11.9 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.16 EDK41290.1 - 0.095 12.1 0.4 0.22 10.9 0.3 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 EDK41290.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sugar_tr PF00083.19 EDK41291.2 - 2.2e-82 277.0 19.6 2.6e-82 276.7 13.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41291.2 - 5.4e-24 84.5 27.9 7.3e-22 77.5 15.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YopH_N PF09013.5 EDK41292.2 - 0.0046 16.6 0.2 0.064 12.9 0.0 2.7 3 0 0 3 3 3 1 YopH, N-terminal Fmp27 PF10344.4 EDK41293.2 - 6.5e-179 596.5 36.3 6.5e-179 596.5 25.1 1.7 2 0 0 2 2 2 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.4 EDK41293.2 - 3.3e-102 342.3 8.8 3.3e-102 342.3 6.1 2.2 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.4 EDK41293.2 - 4.2e-58 195.6 0.0 1.3e-57 194.1 0.0 1.9 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 EDK41293.2 - 2.7e-48 163.7 0.4 8.2e-48 162.1 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 EDK41293.2 - 3.3e-29 101.3 0.8 5.5e-28 97.4 0.1 3.4 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain RabGAP-TBC PF00566.13 EDK41294.2 - 6.3e-52 176.1 1.1 6.3e-52 176.1 0.7 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.15 EDK41294.2 - 1e-08 34.5 0.0 2.8e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.3 EDK41294.2 - 0.00032 20.4 0.0 0.001 18.7 0.0 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EF-hand_6 PF13405.1 EDK41294.2 - 0.02 14.7 1.0 0.71 9.9 0.1 3.5 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.1 EDK41294.2 - 0.041 14.0 0.1 0.22 11.7 0.1 2.3 1 0 0 1 1 1 0 EF-hand domain pair Spc24 PF08286.6 EDK41295.2 - 1.2 8.8 6.9 2.7 7.6 4.8 1.6 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 V_ATPase_I PF01496.14 EDK41295.2 - 1.6 6.4 3.9 2.4 5.9 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 EDK41295.2 - 2.9 6.8 9.4 5.2 6.0 6.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1770 PF08589.5 EDK41296.2 - 0.12 13.0 0.5 0.54 10.9 0.1 1.9 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1770) RNA_pol_A_bac PF01000.21 EDK41297.2 - 1.9e-30 105.2 0.0 3e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 EDK41297.2 - 1.6e-14 52.7 0.0 2.1e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain His_biosynth PF00977.16 EDK41298.2 - 3.5e-27 95.1 0.0 4.2e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF2181 PF10223.4 EDK41298.2 - 0.1 11.9 0.1 0.34 10.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2181) Aldolase PF01081.14 EDK41298.2 - 0.11 11.6 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 KDPG and KHG aldolase Nop25 PF09805.4 EDK41299.2 - 1.5 8.8 9.5 0.66 10.0 2.2 2.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Cnd2 PF05786.9 EDK41300.2 - 9.1e-207 688.9 23.4 1e-206 688.7 16.2 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Gag_p15 PF08723.5 EDK41300.2 - 0.017 15.1 0.3 0.047 13.6 0.0 1.8 2 0 0 2 2 2 0 Gag protein p15 DUF3937 PF13073.1 EDK41300.2 - 0.19 11.6 0.2 12 5.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) Peptidase_M41 PF01434.13 EDK41301.2 - 1.3e-70 237.1 0.2 2.1e-70 236.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EDK41301.2 - 3.3e-41 140.5 0.0 1.5e-40 138.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41301.2 - 2.5e-05 24.4 0.1 0.075 13.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.8 EDK41301.2 - 4.7e-05 22.2 0.0 9.3e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 EDK41301.2 - 6.3e-05 23.0 0.0 0.0002 21.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 EDK41301.2 - 0.00013 22.7 0.0 0.00032 21.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EDK41301.2 - 0.00063 18.8 0.0 0.0073 15.3 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 EDK41301.2 - 0.00072 19.2 0.2 0.004 16.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 EDK41301.2 - 0.0023 17.3 1.0 0.09 12.1 0.5 2.4 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 EDK41301.2 - 0.0023 17.6 2.2 0.0062 16.2 1.5 1.6 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 EDK41301.2 - 0.0055 16.1 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 EDK41301.2 - 0.026 14.4 0.0 0.08 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EDK41301.2 - 0.026 13.5 0.1 0.06 12.4 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_2 PF07724.9 EDK41301.2 - 0.03 14.2 0.0 0.16 11.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) KaiC PF06745.8 EDK41301.2 - 0.033 13.3 0.1 0.48 9.5 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.1 EDK41301.2 - 0.036 14.3 0.1 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 EDK41301.2 - 0.044 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 EDK41301.2 - 0.044 12.9 0.2 0.089 11.9 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SpoU_sub_bind PF08032.7 EDK41301.2 - 0.092 12.9 0.1 36 4.6 0.0 3.0 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding AAA_28 PF13521.1 EDK41301.2 - 0.092 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 EDK41301.2 - 0.12 11.6 0.5 0.37 10.0 0.3 1.8 1 0 0 1 1 1 0 PhoH-like protein HLH PF00010.21 EDK41302.2 - 3.2e-14 52.3 0.1 5.7e-14 51.5 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GCV_T PF01571.16 EDK41303.2 - 3.5e-06 26.5 0.0 0.015 14.6 0.0 2.4 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain FlgD PF03963.9 EDK41303.2 - 0.008 16.2 0.1 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region GCV_T_C PF08669.6 EDK41303.2 - 0.013 15.5 0.1 0.06 13.3 0.0 2.1 1 1 1 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain Cyt-b5 PF00173.23 EDK41303.2 - 0.026 14.3 0.1 0.28 11.0 0.0 2.5 2 1 1 3 3 3 0 Cytochrome b5-like Heme/Steroid binding domain zf-CCHC_4 PF14392.1 EDK41306.2 - 0.036 13.7 4.3 0.09 12.4 3.0 1.7 1 0 0 1 1 1 0 Zinc knuckle Carn_acyltransf PF00755.15 EDK41307.2 - 2e-91 306.8 0.0 3.2e-91 306.2 0.0 1.3 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RIG-I_C-RD PF11648.3 EDK41307.2 - 0.12 12.2 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of RIG-I zf-C2H2 PF00096.21 EDK41308.2 - 1.5e-16 59.6 13.5 3.1e-06 27.2 0.9 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK41308.2 - 1.4e-12 46.9 10.6 0.00011 22.2 0.7 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK41308.2 - 2.1e-11 43.5 19.9 1e-08 35.0 0.5 5.1 5 1 0 5 5 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 EDK41308.2 - 1.5e-05 24.7 6.9 0.043 13.7 0.4 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 EDK41308.2 - 0.0027 17.7 3.5 0.017 15.2 0.6 4.3 4 0 0 4 4 3 2 Zinc-finger double-stranded RNA-binding RRN7 PF11781.3 EDK41308.2 - 0.0046 16.4 2.7 0.12 11.9 0.0 2.7 3 0 0 3 3 3 1 RNA polymerase I-specific transcription initiation factor Rrn7 GAGA PF09237.6 EDK41308.2 - 0.022 14.3 1.3 1.1 8.8 0.2 2.8 1 1 1 2 2 2 0 GAGA factor zf-C2HC_2 PF13913.1 EDK41308.2 - 0.028 14.0 6.6 0.17 11.5 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-FCS PF06467.9 EDK41308.2 - 0.038 13.6 0.5 11 5.7 0.0 2.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn-ribbon_8 PF09723.5 EDK41308.2 - 0.085 12.8 2.9 1.8 8.6 2.0 2.5 1 1 1 2 2 2 0 Zinc ribbon domain Transpos_assoc PF13963.1 EDK41308.2 - 0.094 12.7 2.6 0.17 11.8 0.6 2.2 1 1 1 2 2 2 0 Transposase-associated domain C1_4 PF07975.7 EDK41308.2 - 0.11 12.5 1.4 1 9.4 1.2 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain XPA_N PF01286.13 EDK41308.2 - 0.35 10.5 2.4 12 5.6 0.0 3.2 3 0 0 3 3 3 0 XPA protein N-terminal zf-BED PF02892.10 EDK41308.2 - 0.87 9.4 6.4 4.8 7.0 0.1 3.0 3 0 0 3 3 3 0 BED zinc finger Zn_Tnp_IS1595 PF12760.2 EDK41308.2 - 1.1 9.0 4.3 0.76 9.6 1.5 1.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Pyridox_oxidase PF01243.15 EDK41309.2 - 9.1e-14 51.2 0.0 4.5e-13 49.0 0.0 2.0 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 EDK41309.2 - 0.00029 20.6 0.0 0.0024 17.6 0.0 2.0 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Cas_Cas5d PF09704.5 EDK41309.2 - 0.019 14.6 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) Pyrid_oxidase_2 PF13883.1 EDK41309.2 - 0.038 13.7 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase ORC4_C PF14629.1 EDK41310.2 - 4.8e-50 169.7 1.3 6.8e-50 169.2 0.9 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 EDK41310.2 - 2.6e-13 50.3 0.0 5.1e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EDK41310.2 - 6.1e-11 42.5 0.0 1.7e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 EDK41310.2 - 6.3e-09 35.8 0.1 1.2e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA PF00004.24 EDK41310.2 - 6.8e-08 32.7 0.2 2.8e-07 30.8 0.1 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 EDK41310.2 - 0.00088 19.1 2.0 0.0026 17.6 0.4 2.4 2 1 0 2 2 2 1 AAA domain AAA-ATPase_like PF09820.4 EDK41310.2 - 0.0024 17.0 0.5 0.0081 15.3 0.4 1.9 1 1 0 1 1 1 1 Predicted AAA-ATPase AAA_5 PF07728.9 EDK41310.2 - 0.0035 17.0 0.0 0.0076 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.9 EDK41310.2 - 0.016 14.1 0.2 3.1 6.7 0.2 2.8 2 1 1 3 3 3 0 KAP family P-loop domain AAA_2 PF07724.9 EDK41310.2 - 0.019 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NTPase_1 PF03266.10 EDK41310.2 - 0.019 14.6 0.9 0.25 11.0 0.1 2.6 2 1 0 2 2 2 0 NTPase AAA_33 PF13671.1 EDK41310.2 - 0.038 13.8 0.0 0.083 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 EDK41310.2 - 0.043 12.9 0.0 0.081 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activ_2 PF14532.1 EDK41310.2 - 0.1 12.6 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Glyco_tran_WecB PF03808.8 EDK41310.2 - 0.11 11.8 0.0 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family RGS PF00615.14 EDK41311.2 - 1.7e-14 53.9 0.0 7e-14 51.9 0.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain GTP_EFTU PF00009.22 EDK41312.1 - 1.8e-38 131.8 0.1 3e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 EDK41312.1 - 2.6e-35 120.3 0.3 5.5e-35 119.2 0.2 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 EDK41312.1 - 1.6e-10 40.9 1.6 2.8e-10 40.1 0.3 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EDK41312.1 - 0.0061 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 EDK41312.1 - 0.05 13.4 0.9 0.19 11.5 0.0 2.4 2 1 0 2 2 2 0 Dynamin family Fungal_trans PF04082.13 EDK41313.2 - 4.6e-11 42.0 2.3 9.4e-11 41.0 0.1 2.4 2 1 1 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41313.2 - 1.9e-08 34.0 11.5 3.3e-08 33.3 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 EDK41314.2 - 1.5e-29 102.8 46.9 6.3e-27 94.2 15.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 EDK41314.2 - 3.1e-14 52.2 17.1 9.9e-08 30.7 5.2 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.8 EDK41314.2 - 0.00035 18.8 7.7 0.004 15.3 0.2 2.6 2 1 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.2 EDK41314.2 - 0.00052 19.7 2.6 0.0018 18.0 0.4 2.9 3 0 0 3 3 3 1 MFS_1 like family Sugar_tr PF00083.19 EDK41314.2 - 0.089 11.3 24.5 1 7.8 17.0 2.7 1 1 0 1 1 1 0 Sugar (and other) transporter OATP PF03137.15 EDK41314.2 - 2.6 6.0 12.8 0.015 13.3 0.7 2.7 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family AA_permease PF00324.16 EDK41315.2 - 3.6e-120 401.5 42.4 4.5e-120 401.2 29.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK41315.2 - 6.1e-38 130.4 44.1 7.2e-38 130.2 30.6 1.0 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_7 PF13508.1 EDK41316.2 - 2.5e-07 30.7 0.5 1.9e-06 27.9 0.3 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 EDK41316.2 - 1.2e-05 25.2 0.9 0.0035 17.1 0.0 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 EDK41316.2 - 0.00012 21.9 0.1 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.1 EDK41316.2 - 0.012 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.5 EDK41316.2 - 0.042 13.6 0.1 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_3 PF13302.1 EDK41316.2 - 0.08 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IFN-gamma PF00714.12 EDK41316.2 - 0.091 12.5 0.2 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Interferon gamma Acetyltransf_8 PF13523.1 EDK41316.2 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CYSTM PF12734.2 EDK41317.2 - 4.9e-05 23.3 47.3 0.00037 20.4 24.3 4.7 2 2 0 2 2 2 1 Cysteine-rich TM module stress tolerance MFS_1 PF07690.11 EDK41318.1 - 2.2e-26 92.4 25.6 2.2e-26 92.4 17.8 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3169 PF11368.3 EDK41318.1 - 0.054 12.6 0.8 0.39 9.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Ribosomal_S7 PF00177.16 EDK41319.1 - 4.8e-38 130.0 2.6 6.4e-38 129.6 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Lyase_1 PF00206.15 EDK41319.1 - 0.0018 17.5 0.1 0.0022 17.2 0.1 1.3 1 0 0 1 1 1 1 Lyase MFS_1 PF07690.11 EDK41320.2 - 3.8e-16 58.7 31.2 3.8e-16 58.7 21.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DNA_ligase_A_M PF01068.16 EDK41320.2 - 0.072 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Zip PF02535.17 EDK41320.2 - 0.75 8.7 12.3 0.53 9.2 3.0 2.5 2 1 0 2 2 2 0 ZIP Zinc transporter Spore_YtrH PF14034.1 EDK41320.2 - 5.5 6.9 10.4 0.089 12.7 0.3 2.5 3 0 0 3 3 3 0 Sporulation protein YtrH AAA PF00004.24 EDK41321.2 - 2.9e-42 144.0 0.0 5e-42 143.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 EDK41321.2 - 1.3e-30 105.0 0.1 4.7e-29 100.0 0.1 3.0 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 EDK41321.2 - 6.5e-22 77.1 4.6 1.9e-21 75.6 2.8 2.1 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain RNA_helicase PF00910.17 EDK41321.2 - 2.3e-06 27.7 1.1 0.0094 16.1 0.0 3.8 4 0 0 4 4 3 1 RNA helicase AAA_17 PF13207.1 EDK41321.2 - 2.4e-06 28.3 0.0 1.7e-05 25.5 0.0 2.5 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 EDK41321.2 - 4.6e-06 26.4 0.0 2.5e-05 24.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 EDK41321.2 - 1.3e-05 24.7 0.0 4.3e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.1 EDK41321.2 - 2.5e-05 24.4 0.5 0.0017 18.4 0.1 2.8 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 EDK41321.2 - 2.6e-05 24.2 0.2 0.00036 20.5 0.0 2.4 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.7 EDK41321.2 - 3.7e-05 22.8 0.0 6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 EDK41321.2 - 4.3e-05 23.4 0.0 0.00014 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 EDK41321.2 - 6.8e-05 21.9 0.0 0.00036 19.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 EDK41321.2 - 0.00024 19.9 0.0 0.00041 19.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 EDK41321.2 - 0.00037 19.9 0.1 0.12 11.8 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 EDK41321.2 - 0.00043 20.1 0.0 0.0012 18.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 EDK41321.2 - 0.00048 20.0 0.0 0.0021 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 EDK41321.2 - 0.0079 16.5 0.1 0.025 14.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 EDK41321.2 - 0.016 14.9 0.3 0.051 13.3 0.0 1.9 2 0 0 2 2 1 0 Part of AAA domain Zeta_toxin PF06414.7 EDK41321.2 - 0.017 14.2 0.1 0.18 10.9 0.0 2.4 1 1 1 2 2 2 0 Zeta toxin Mg_chelatase PF01078.16 EDK41321.2 - 0.02 14.0 0.0 0.062 12.4 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 EDK41321.2 - 0.022 14.4 0.0 0.6 9.7 0.0 2.4 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.11 EDK41321.2 - 0.03 13.5 0.0 0.061 12.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.1 EDK41321.2 - 0.036 13.6 1.8 0.039 13.5 0.0 1.9 3 0 0 3 3 2 0 AAA domain ResIII PF04851.10 EDK41321.2 - 0.038 13.8 0.5 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.12 EDK41321.2 - 0.048 12.5 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Torsin PF06309.6 EDK41321.2 - 0.049 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.21 EDK41321.2 - 0.07 12.5 0.0 0.2 11.1 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 EDK41321.2 - 0.083 12.9 0.0 0.27 11.2 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain KaiC PF06745.8 EDK41321.2 - 0.089 11.8 0.0 3.7 6.6 0.0 2.3 1 1 1 2 2 2 0 KaiC Arch_ATPase PF01637.13 EDK41321.2 - 0.1 12.2 2.0 0.35 10.5 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase AAA_28 PF13521.1 EDK41321.2 - 0.11 12.4 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2414 PF10309.4 EDK41322.1 - 8.2e-30 102.2 0.3 1.5e-29 101.4 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2414) PIG-U PF06728.8 EDK41323.2 - 2.2e-76 257.2 20.4 2.4e-76 257.0 14.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Peptidase_M16 PF00675.15 EDK41324.1 - 9.9e-18 64.3 0.2 2.3e-17 63.1 0.0 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 EDK41324.1 - 4.4e-11 42.8 0.0 8e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain RNA_pol_Rpb6 PF01192.17 EDK41327.1 - 3.1e-22 78.0 0.2 4.9e-22 77.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 EF-hand_6 PF13405.1 EDK41328.2 - 0.00012 21.6 0.4 0.0044 16.7 0.0 3.2 3 1 1 4 4 4 1 EF-hand domain EF-hand_7 PF13499.1 EDK41328.2 - 0.012 15.7 1.4 0.03 14.4 0.4 2.2 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.1 EDK41328.2 - 0.019 14.5 0.1 0.27 10.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Actin PF00022.14 EDK41329.1 - 5.5e-129 430.0 0.0 6.3e-129 429.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 EDK41329.1 - 0.013 14.1 0.3 2.1 6.8 0.0 2.4 2 1 0 2 2 2 0 MreB/Mbl protein UPRTase PF14681.1 EDK41330.1 - 1.2e-75 253.2 0.0 1.5e-75 252.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 EDK41330.1 - 0.0067 16.1 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 EDK41330.1 - 0.071 12.8 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) CAP_GLY PF01302.20 EDK41331.2 - 1.9e-23 81.9 1.0 3.2e-23 81.2 0.7 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 EDK41331.2 - 8.3e-18 64.4 0.0 1.5e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF3052 PF11253.3 EDK41331.2 - 0.0066 16.0 0.1 0.0099 15.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3052) PGA2 PF07543.7 EDK41332.2 - 1.2e-09 38.1 11.8 2e-05 24.3 2.8 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 OmpH PF03938.9 EDK41332.2 - 0.0039 17.1 7.2 0.0047 16.8 5.0 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) ATP-synt PF00231.14 EDK41332.2 - 0.0075 15.6 0.3 0.0085 15.4 0.2 1.1 1 0 0 1 1 1 1 ATP synthase Topoisom_I PF01028.15 EDK41332.2 - 0.023 13.8 0.9 0.028 13.5 0.6 1.0 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core FAM176 PF14851.1 EDK41332.2 - 0.027 14.1 0.3 0.032 13.9 0.2 1.1 1 0 0 1 1 1 0 FAM176 family Bap31 PF05529.7 EDK41332.2 - 0.3 10.5 2.5 0.37 10.2 1.7 1.3 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like WD40 PF00400.27 EDK41333.2 - 3.2e-24 83.8 5.6 1.1e-08 34.6 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat RNA_pol_3_Rpc31 PF11705.3 EDK41334.2 - 2.7e-51 174.7 8.3 3.6e-51 174.3 5.8 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 C2 PF00168.25 EDK41335.2 - 1.5e-08 34.3 0.0 3.4e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain MRP-L20 PF12824.2 EDK41337.1 - 1.2e-49 168.3 1.1 1.4e-49 168.2 0.8 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.6 EDK41337.1 - 0.021 14.6 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Neugrin HTH_11 PF08279.7 EDK41337.1 - 0.024 14.3 0.0 0.047 13.3 0.0 1.5 1 0 0 1 1 1 0 HTH domain Lipocalin_5 PF13924.1 EDK41337.1 - 0.05 13.2 0.5 2.8 7.6 0.3 2.1 1 1 1 2 2 2 0 Lipocalin-like domain Ndc80_HEC PF03801.8 EDK41338.2 - 9.1e-52 174.7 0.0 1.9e-51 173.6 0.0 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family Reo_sigmaC PF04582.7 EDK41338.2 - 0.0083 15.3 8.8 0.33 10.0 0.4 2.3 2 0 0 2 2 2 2 Reovirus sigma C capsid protein Mt_ATP-synt_D PF05873.7 EDK41338.2 - 0.023 14.3 10.7 0.39 10.3 0.3 3.5 2 1 1 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) EzrA PF06160.7 EDK41338.2 - 0.029 12.5 25.5 0.047 11.8 9.4 2.3 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA ADIP PF11559.3 EDK41338.2 - 0.16 11.8 27.4 0.21 11.5 4.8 4.1 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding Tup_N PF08581.5 EDK41338.2 - 0.17 12.0 0.1 0.17 12.0 0.1 5.0 3 2 1 5 5 5 0 Tup N-terminal NPV_P10 PF05531.7 EDK41338.2 - 0.19 11.9 6.7 3.9 7.8 0.1 4.6 3 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.2 EDK41338.2 - 0.4 10.5 27.5 0.32 10.8 5.7 3.7 2 2 1 3 3 3 0 Tropomyosin like IncA PF04156.9 EDK41338.2 - 0.78 9.3 27.7 4.9 6.7 6.1 3.4 2 2 0 2 2 2 0 IncA protein KLRAQ PF10205.4 EDK41338.2 - 0.98 9.4 13.4 0.94 9.5 0.1 3.3 2 1 0 3 3 3 0 Predicted coiled-coil domain-containing protein TPR_MLP1_2 PF07926.7 EDK41338.2 - 1.1 9.0 27.8 17 5.1 7.2 4.6 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein DNA_repr_REX1B PF14966.1 EDK41338.2 - 1.1 9.6 9.9 0.55 10.6 0.2 3.8 2 2 2 4 4 4 0 DNA repair REX1-B V_ATPase_I PF01496.14 EDK41338.2 - 1.3 6.8 20.0 0.033 12.0 3.2 2.3 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family TMF_TATA_bd PF12325.3 EDK41338.2 - 1.6 8.4 27.1 1.4 8.6 1.3 5.2 2 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding FlaC_arch PF05377.6 EDK41338.2 - 2.4 8.1 13.1 0.68 9.8 0.1 4.9 4 2 1 5 5 5 0 Flagella accessory protein C (FlaC) FliD_C PF07195.7 EDK41338.2 - 3.1 7.0 15.4 9.6 5.4 0.2 3.7 3 2 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DUF4407 PF14362.1 EDK41338.2 - 5.3 5.9 16.2 1.2 7.9 3.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) SlyX PF04102.7 EDK41338.2 - 6.4 7.2 17.8 0.21 11.9 1.4 4.8 4 1 1 5 5 5 0 SlyX Glyco_hydro_2 PF00703.16 EDK41340.2 - 2e-07 31.4 0.0 5.1e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.13 EDK41340.2 - 7.3e-05 22.3 0.1 0.00021 20.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain FlgD_ig PF13860.1 EDK41340.2 - 0.0029 17.3 0.4 0.1 12.3 0.0 2.6 2 0 0 2 2 2 1 FlgD Ig-like domain DUF3636 PF12331.3 EDK41341.1 - 0.056 13.0 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) HMG_box PF00505.14 EDK41342.2 - 1.5e-17 63.5 1.2 3.4e-17 62.4 0.8 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 EDK41342.2 - 1.2e-07 31.9 0.2 1.2e-07 31.9 0.2 1.8 2 0 0 2 2 2 1 HMG-box domain DUF4407 PF14362.1 EDK41342.2 - 0.067 12.1 3.9 0.091 11.7 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PTP_N PF12453.3 EDK41342.2 - 0.068 12.7 1.2 0.4 10.3 0.8 2.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase N terminal FAM60A PF15396.1 EDK41342.2 - 0.34 10.6 5.5 0.84 9.3 3.8 1.6 1 0 0 1 1 1 0 Protein Family FAM60A ABC2_membrane_3 PF12698.2 EDK41342.2 - 0.44 9.5 3.0 0.16 11.0 0.1 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein COG2 PF06148.6 EDK41343.2 - 1.1e-20 73.8 1.5 1.1e-20 73.8 1.1 1.6 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 EDK41343.2 - 0.00067 19.4 2.7 0.0041 16.9 0.4 2.8 1 1 1 2 2 2 1 Vps51/Vps67 DUF848 PF05852.6 EDK41343.2 - 0.013 15.4 0.5 0.041 13.7 0.0 2.0 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Colipase-like PF15083.1 EDK41344.2 - 0.0043 16.9 5.4 0.0069 16.2 3.8 1.3 1 0 0 1 1 1 1 Colipase-like CHCH PF06747.8 EDK41344.2 - 0.013 15.3 11.4 0.11 12.5 2.8 2.5 2 0 0 2 2 2 0 CHCH domain COX6B PF02297.12 EDK41344.2 - 2.4 8.2 8.8 6.3 6.8 2.2 2.3 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 EDK41344.2 - 2.5 8.2 7.5 2.9 7.9 2.6 2.6 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Nup54 PF13874.1 EDK41346.2 - 1.8e-38 131.3 0.6 4.1e-38 130.2 0.1 1.8 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 EDK41346.2 - 5.1e-29 100.8 164.1 4.7e-14 52.5 34.4 4.4 1 1 3 4 4 4 4 Nucleoporin FG repeat region HA2 PF04408.18 EDK41348.2 - 2e-19 69.4 0.2 1e-18 67.2 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 EDK41348.2 - 1.8e-17 63.2 0.3 6e-17 61.5 0.2 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 EDK41348.2 - 2.1e-13 49.9 0.0 6.6e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 EDK41348.2 - 1.7e-07 30.8 0.1 4.5e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 EDK41348.2 - 1.1e-06 28.8 0.1 2.9e-06 27.4 0.1 1.8 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.9 EDK41348.2 - 0.0036 17.0 0.0 0.0084 15.8 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SE PF00437.15 EDK41348.2 - 0.01 14.7 0.1 0.022 13.6 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.22 EDK41348.2 - 0.027 14.7 0.8 0.31 11.3 0.0 2.9 3 0 0 3 3 2 0 ABC transporter ResIII PF04851.10 EDK41348.2 - 0.032 14.0 9.7 0.1 12.4 0.0 3.7 3 2 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_14 PF13173.1 EDK41348.2 - 0.038 13.8 0.6 1.6 8.6 0.4 2.8 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 EDK41348.2 - 0.053 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 EDK41348.2 - 0.054 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 EDK41348.2 - 0.14 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 EDK41348.2 - 0.19 12.0 0.1 0.19 12.0 0.1 3.6 3 2 1 4 4 4 0 AAA domain Pantoate_ligase PF02569.10 EDK41349.2 - 7.1e-95 316.9 0.1 8.2e-95 316.7 0.1 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Abhydrolase_6 PF12697.2 EDK41350.2 - 2.3e-24 86.5 0.0 2.8e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK41350.2 - 4.9e-09 36.0 0.1 3.6e-08 33.2 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41350.2 - 6.7e-06 25.8 0.0 3.5e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 EDK41350.2 - 0.00074 19.0 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 EDK41350.2 - 0.021 14.0 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family PAF-AH_p_II PF03403.8 EDK41350.2 - 0.048 11.9 0.0 0.082 11.1 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Tecti-min-caps PF09300.5 EDK41350.2 - 0.14 11.9 0.0 0.37 10.6 0.0 1.6 2 0 0 2 2 2 0 Tectiviridae, minor capsid SRP40_C PF05022.7 EDK41351.1 - 6.3e-31 106.6 3.6 1.2e-30 105.8 2.5 1.5 1 0 0 1 1 1 1 SRP40, C-terminal domain MIP-T3 PF10243.4 EDK41351.1 - 2.1 6.7 31.0 2.6 6.4 21.5 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Helicase_C_3 PF13625.1 EDK41352.2 - 3.5e-25 88.2 0.2 1.8e-24 85.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK41352.2 - 2.3e-14 53.6 0.0 5.2e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 EDK41352.2 - 1.3e-11 44.2 0.0 3e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 EDK41352.2 - 2.1e-11 43.2 0.1 3.1e-11 42.6 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 EDK41352.2 - 5.3e-07 29.2 0.0 1.1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.1 EDK41352.2 - 0.024 13.4 0.0 0.037 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 SBP_bac_6 PF13343.1 EDK41352.2 - 0.034 13.4 0.0 0.075 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein DUF1681 PF07933.9 EDK41353.2 - 2.4e-05 23.9 0.2 0.096 12.2 0.0 2.2 2 1 0 2 2 2 2 Protein of unknown function (DUF1681) Aldedh PF00171.17 EDK41354.2 - 5.7e-74 249.1 0.0 6.9e-74 248.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_S21 PF01165.15 EDK41355.2 - 3.6e-10 39.1 2.0 6.3e-10 38.3 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 Mito_carr PF00153.22 EDK41356.2 - 7.5e-47 156.9 6.7 4.5e-19 67.9 0.1 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein WGG PF10273.4 EDK41358.1 - 6.7 6.8 9.5 20 5.3 3.3 2.9 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 RNA_pol_Rpc82 PF05645.8 EDK41359.2 - 3.3e-68 230.0 0.8 5.8e-67 225.9 0.3 2.1 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 EDK41359.2 - 3.5e-18 65.2 2.6 5.3e-18 64.6 0.4 2.4 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 EDK41359.2 - 4e-06 26.2 1.0 0.047 13.2 0.0 3.6 3 0 0 3 3 3 2 TFIIE alpha subunit TrmB PF01978.14 EDK41359.2 - 0.0043 16.7 1.3 0.031 13.9 0.0 3.1 4 0 0 4 4 4 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 EDK41359.2 - 0.03 13.7 0.5 0.16 11.3 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_43 PF09904.4 EDK41359.2 - 0.097 12.4 0.0 0.42 10.4 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix TPR_11 PF13414.1 EDK41360.2 - 1.3e-41 140.0 26.1 1.7e-09 37.1 0.0 11.7 8 4 6 14 14 14 10 TPR repeat TPR_19 PF14559.1 EDK41360.2 - 2.4e-25 88.6 10.2 1.3e-06 28.6 0.0 10.6 8 3 3 11 11 11 4 Tetratricopeptide repeat TPR_2 PF07719.12 EDK41360.2 - 6.3e-24 81.9 32.4 6.4e-06 25.6 0.1 15.3 18 0 0 18 18 18 4 Tetratricopeptide repeat TPR_16 PF13432.1 EDK41360.2 - 1.5e-22 79.6 9.7 0.0002 21.9 0.0 9.4 8 2 2 10 10 9 4 Tetratricopeptide repeat TPR_1 PF00515.23 EDK41360.2 - 6.3e-22 76.2 27.7 8.7e-06 25.1 0.0 13.0 13 2 0 13 13 13 6 Tetratricopeptide repeat TPR_17 PF13431.1 EDK41360.2 - 4e-21 73.4 8.9 0.0044 17.1 0.1 12.0 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_12 PF13424.1 EDK41360.2 - 4.4e-21 74.6 25.8 0.00053 19.8 0.0 10.3 5 4 5 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.1 EDK41360.2 - 2.2e-19 67.6 15.9 0.0031 17.1 0.0 11.6 11 4 0 11 11 11 4 Tetratricopeptide repeat Apc3 PF12895.2 EDK41360.2 - 3.3e-19 68.8 21.3 3.7e-06 26.9 0.0 8.3 7 2 2 9 9 9 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 EDK41360.2 - 7e-19 66.6 16.0 4.2e-05 23.8 0.0 12.4 11 3 3 14 14 12 3 Tetratricopeptide repeat TPR_9 PF13371.1 EDK41360.2 - 1e-11 44.4 0.2 0.065 13.0 0.0 6.9 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 EDK41360.2 - 3.3e-08 32.7 10.9 0.0053 16.4 0.0 8.7 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_6 PF13174.1 EDK41360.2 - 4.4e-08 33.0 9.3 8.7 7.0 0.0 9.5 10 0 0 10 10 10 1 Tetratricopeptide repeat NARP1 PF12569.3 EDK41360.2 - 0.00025 19.9 1.3 0.024 13.4 0.0 3.4 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_4 PF07721.9 EDK41360.2 - 0.00065 19.8 0.5 2.4 8.8 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 EDK41360.2 - 0.026 14.4 11.7 0.95 9.4 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 EDK41360.2 - 2.3 7.5 8.7 27 4.1 0.0 4.4 5 0 0 5 5 5 0 SHNi-TPR ATG13 PF10033.4 EDK41361.2 - 3.8e-71 239.1 0.0 6.5e-71 238.4 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 AFG1_ATPase PF03969.11 EDK41362.2 - 9.9e-77 258.1 0.0 2e-72 244.0 0.0 2.4 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 EDK41362.2 - 0.00012 22.1 0.3 0.17 11.8 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_14 PF13173.1 EDK41362.2 - 0.0047 16.8 0.0 0.051 13.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 EDK41362.2 - 0.014 15.6 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41362.2 - 0.016 15.3 0.1 0.23 11.5 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.9 EDK41362.2 - 0.031 14.0 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 EDK41362.2 - 0.035 13.7 0.4 1.5 8.4 0.0 2.5 2 1 1 3 3 3 0 Archaeal ATPase NACHT PF05729.7 EDK41362.2 - 0.045 13.4 0.0 0.087 12.4 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 EDK41362.2 - 0.053 13.6 0.0 0.22 11.7 0.0 2.2 1 1 0 1 1 1 0 RNA helicase Heme_oxygenase PF01126.15 EDK41363.2 - 0.0051 16.4 0.0 0.021 14.3 0.0 2.0 2 0 0 2 2 2 1 Heme oxygenase Suf PF05843.9 EDK41364.2 - 2.8e-12 46.9 17.5 0.00032 20.5 0.0 6.7 6 1 1 7 7 7 4 Suppressor of forked protein (Suf) TPR_14 PF13428.1 EDK41364.2 - 1.9e-08 34.2 0.0 2.4 9.0 0.0 6.1 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 EDK41364.2 - 1.3e-07 31.4 0.4 1.2 9.0 0.0 5.3 5 1 0 5 5 4 2 Tetratricopeptide repeat NRDE-2 PF08424.5 EDK41364.2 - 1.2e-05 24.3 8.5 1.4e-05 24.1 1.5 4.1 4 2 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_11 PF13414.1 EDK41364.2 - 1.9e-05 24.1 0.5 1 9.0 0.0 5.1 5 1 1 6 6 6 1 TPR repeat SNAP PF14938.1 EDK41364.2 - 0.00014 21.1 0.8 0.4 9.7 0.1 2.6 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_2 PF07719.12 EDK41364.2 - 0.0035 17.1 1.7 5.4 7.1 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK41364.2 - 0.0065 17.1 0.0 42 4.9 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 EDK41364.2 - 0.013 15.6 1.4 85 3.7 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 EDK41364.2 - 0.085 12.6 5.1 4.1 7.3 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 EDK41364.2 - 0.092 12.8 1.0 19 5.4 0.0 3.5 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Peptidase_M3_N PF08439.5 EDK41364.2 - 0.18 11.8 2.9 2.4 8.2 0.0 3.0 2 0 0 2 2 2 0 Oligopeptidase F TPR_6 PF13174.1 EDK41364.2 - 0.21 12.0 6.9 68 4.2 0.0 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat KNOX2 PF03791.8 EDK41364.2 - 0.61 9.4 4.0 1.1 8.6 0.2 3.0 3 0 0 3 3 3 0 KNOX2 domain ATP-synt_D PF01813.12 EDK41365.1 - 1.1e-66 224.1 6.0 1.5e-66 223.6 4.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit D ThiF PF00899.16 EDK41365.1 - 0.12 12.2 2.2 0.29 10.9 0.5 2.2 2 0 0 2 2 2 0 ThiF family DUF1664 PF07889.7 EDK41365.1 - 0.68 9.7 4.6 0.3 10.9 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RICH PF05062.7 EDK41365.1 - 0.73 9.9 6.2 0.45 10.6 1.6 2.5 2 1 0 2 2 2 0 RICH domain DUF4615 PF15393.1 EDK41365.1 - 0.75 10.0 6.6 0.34 11.1 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) adh_short PF00106.20 EDK41366.1 - 1.3e-23 83.7 0.2 1.6e-23 83.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 EDK41366.1 - 1.5e-22 80.5 0.1 1.8e-22 80.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 EDK41366.1 - 2.1e-13 50.3 0.1 3e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF4325 PF14213.1 EDK41366.1 - 0.017 14.7 0.1 0.39 10.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4325) ThiF PF00899.16 EDK41366.1 - 0.041 13.6 0.1 0.076 12.8 0.1 1.4 1 0 0 1 1 1 0 ThiF family FAD_binding_2 PF00890.19 EDK41367.1 - 1.7e-123 412.5 3.1 2.2e-123 412.2 2.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 EDK41367.1 - 6.7e-49 165.0 0.6 1e-48 164.4 0.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.12 EDK41367.1 - 4.2e-07 29.3 0.1 0.0005 19.2 0.0 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.9 EDK41367.1 - 6e-06 26.2 2.2 0.00018 21.4 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 EDK41367.1 - 1.2e-05 24.4 0.4 0.001 18.0 0.5 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.19 EDK41367.1 - 9.9e-05 21.3 0.8 0.00059 18.8 0.2 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 EDK41367.1 - 0.0038 16.3 0.1 0.0085 15.1 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 EDK41367.1 - 0.0078 15.1 0.3 0.84 8.4 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein HI0933_like PF03486.9 EDK41367.1 - 0.02 13.3 0.0 0.089 11.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Antimicrobial_7 PF08102.6 EDK41367.1 - 0.092 12.7 0.2 7 6.7 0.0 2.6 2 0 0 2 2 2 0 Scorpion antimicrobial peptide adh_short_C2 PF13561.1 EDK41368.1 - 4.2e-30 105.2 0.0 5.1e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 EDK41368.1 - 1.1e-23 83.9 0.0 1.4e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 EDK41368.1 - 3.3e-09 36.6 0.0 4.7e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 EDK41368.1 - 0.0007 19.0 0.0 0.0023 17.4 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 EDK41368.1 - 0.007 16.7 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Saccharop_dh PF03435.13 EDK41368.1 - 0.014 14.4 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase DFP PF04127.10 EDK41368.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_10 PF13460.1 EDK41368.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.7 1 1 0 1 1 1 0 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 EDK41368.1 - 0.036 13.8 0.5 0.079 12.7 0.1 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 2-Hacid_dh_C PF02826.14 EDK41368.1 - 0.052 12.7 0.0 0.083 12.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF4115 PF13464.1 EDK41368.1 - 0.053 13.1 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) FMN_dh PF01070.13 EDK41368.1 - 0.085 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase YjeF_N PF03853.10 EDK41368.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus PuR_N PF09182.5 EDK41368.1 - 0.23 11.0 1.9 1.8 8.2 0.1 2.9 3 1 0 3 3 3 0 Bacterial purine repressor, N-terminal CENP-B_dimeris PF09026.5 EDK41369.2 - 2.8 8.2 10.7 0.11 12.7 2.5 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PX PF00787.19 EDK41370.2 - 3.6e-21 75.0 0.0 5.2e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 EDK41370.2 - 8.2e-07 28.5 0.0 1.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Vps5 C terminal like Vps5 PF09325.5 EDK41371.2 - 1.8e-67 227.0 11.7 2e-67 226.8 8.1 1.0 1 0 0 1 1 1 1 Vps5 C terminal like DUF496 PF04363.7 EDK41371.2 - 0.00048 19.8 2.4 0.0052 16.5 0.2 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF496) DUF1237 PF06824.6 EDK41371.2 - 0.00061 18.5 0.3 0.00064 18.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) FAM92 PF06730.6 EDK41371.2 - 0.0018 17.6 7.8 0.0047 16.2 5.3 1.6 1 1 0 1 1 1 1 FAM92 protein DivIC PF04977.10 EDK41371.2 - 0.0094 15.4 5.3 0.027 13.9 1.8 2.5 2 0 0 2 2 2 1 Septum formation initiator BAR PF03114.13 EDK41371.2 - 0.0099 15.4 6.1 0.015 14.8 4.2 1.3 1 0 0 1 1 1 1 BAR domain FliD_N PF02465.13 EDK41371.2 - 0.022 15.1 1.8 0.022 15.1 1.2 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Imm8 PF15560.1 EDK41371.2 - 0.024 14.3 0.2 0.074 12.7 0.1 1.8 2 0 0 2 2 2 0 Immunity protein 8 DUF869 PF05911.6 EDK41371.2 - 0.027 12.7 9.3 0.031 12.5 6.4 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) ADIP PF11559.3 EDK41371.2 - 0.029 14.2 6.3 0.038 13.8 3.6 1.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HrpB7 PF09486.5 EDK41371.2 - 0.03 14.2 0.4 0.13 12.1 0.1 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Ax_dynein_light PF10211.4 EDK41371.2 - 0.035 13.9 6.0 0.028 14.2 2.9 1.6 2 0 0 2 2 2 0 Axonemal dynein light chain COG5 PF10392.4 EDK41371.2 - 0.071 13.0 7.0 0.88 9.5 0.9 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 GAS PF13851.1 EDK41371.2 - 0.088 11.9 9.1 0.031 13.4 3.9 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.6 EDK41371.2 - 0.094 12.5 7.6 0.16 11.7 4.8 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.15 EDK41371.2 - 0.11 11.5 8.6 0.041 12.9 4.0 1.7 2 0 0 2 2 2 0 Tropomyosin Cauli_AT PF03233.8 EDK41371.2 - 0.16 11.6 7.0 0.055 13.1 2.7 1.9 2 1 0 2 2 2 0 Aphid transmission protein DUF972 PF06156.8 EDK41371.2 - 0.17 12.2 6.8 0.28 11.5 3.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Mt_ATP-synt_B PF05405.9 EDK41371.2 - 0.24 10.8 12.1 0.68 9.3 5.2 2.7 2 1 1 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Sec8_exocyst PF04048.9 EDK41371.2 - 0.51 9.9 10.3 0.2 11.2 3.3 2.3 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Exonuc_VII_L PF02601.10 EDK41371.2 - 1.4 8.0 7.7 0.98 8.5 4.2 1.6 1 1 0 2 2 2 0 Exonuclease VII, large subunit DUF2203 PF09969.4 EDK41371.2 - 1.4 9.1 6.0 0.94 9.7 1.1 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) BLOC1_2 PF10046.4 EDK41371.2 - 2.8 8.1 10.6 1.4 9.1 2.8 2.9 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.7 EDK41371.2 - 3.1 8.2 8.2 6.7 7.1 0.1 3.3 2 1 1 3 3 3 0 SlyX DUF1664 PF07889.7 EDK41371.2 - 4.3 7.1 6.6 2.9 7.7 1.9 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ACT_7 PF13840.1 EDK41372.2 - 1.4e-26 91.7 0.1 9.2e-14 50.7 0.0 2.9 2 1 0 2 2 2 2 ACT domain GYF PF02213.11 EDK41373.2 - 1.7e-16 59.5 0.1 3.5e-16 58.5 0.1 1.6 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.1 EDK41373.2 - 0.0018 17.7 0.5 0.0051 16.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) Phage_integrase PF00589.17 EDK41373.2 - 0.044 13.4 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family RRP7 PF12923.2 EDK41373.2 - 4 7.4 9.0 0.82 9.6 0.4 3.1 2 1 1 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) UMP1 PF05348.6 EDK41374.2 - 6.4e-26 90.8 0.0 8.7e-26 90.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Nuc_sug_transp PF04142.10 EDK41375.2 - 5.9e-13 48.4 0.7 5.9e-13 48.4 0.5 1.9 2 0 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.6 EDK41375.2 - 1.1e-09 37.6 13.0 1.1e-09 37.6 9.0 1.6 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.15 EDK41375.2 - 2.7e-06 27.4 2.8 2.7e-06 27.4 1.9 3.1 3 1 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 EDK41375.2 - 2.8e-06 27.4 3.5 2.8e-06 27.4 2.4 3.1 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 EDK41375.2 - 0.0005 19.8 0.4 0.0005 19.8 0.3 2.5 2 0 0 2 2 2 1 Uncharacterised protein family UPF0546 YrhC PF14143.1 EDK41375.2 - 0.15 12.0 2.8 3.8 7.5 0.0 2.9 2 0 0 2 2 2 0 YrhC-like protein TPT PF03151.11 EDK41375.2 - 1.7 8.3 25.9 0.43 10.2 1.6 3.0 3 1 0 3 3 3 0 Triose-phosphate Transporter family Multi_Drug_Res PF00893.14 EDK41375.2 - 3 8.3 13.0 2.9 8.4 0.4 2.9 2 0 0 2 2 2 0 Small Multidrug Resistance protein Fibrillarin PF01269.12 EDK41376.1 - 2.4e-107 357.0 0.0 3e-107 356.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 EDK41376.1 - 4.9e-06 26.2 0.1 1.2e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Shadoo PF14999.1 EDK41376.1 - 0.028 14.2 19.0 0.028 14.2 13.2 3.4 1 1 1 2 2 2 0 Shadow of prion protein, neuroprotective PCMT PF01135.14 EDK41376.1 - 0.085 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-RING_5 PF14634.1 EDK41377.2 - 0.0008 19.0 1.7 0.0008 19.0 1.2 1.9 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 EDK41377.2 - 0.0016 18.0 2.3 0.0017 17.9 0.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 EDK41377.2 - 0.0038 17.0 0.8 0.0096 15.7 0.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 EDK41377.2 - 0.0053 16.6 2.1 0.0057 16.5 0.1 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 EDK41377.2 - 0.017 14.8 0.8 0.036 13.7 0.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.1 EDK41377.2 - 0.028 14.4 4.5 0.028 14.4 3.1 2.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 EDK41377.2 - 0.059 12.5 0.2 0.059 12.5 0.1 2.4 3 0 0 3 3 3 0 Rtf2 RING-finger zf-C3HC4_3 PF13920.1 EDK41377.2 - 1.9 8.2 6.3 0.31 10.7 1.5 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Usp PF00582.21 EDK41378.2 - 1e-20 74.3 0.6 3.8e-20 72.5 0.0 2.1 2 1 0 2 2 2 1 Universal stress protein family YkyA PF10368.4 EDK41378.2 - 0.47 9.7 11.3 0.037 13.3 3.3 2.5 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein UBA_4 PF14555.1 EDK41379.2 - 1.6e-14 53.1 0.1 3.6e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 EDK41379.2 - 3.5e-13 49.4 0.1 1.1e-12 47.8 0.0 1.9 2 0 0 2 2 2 1 UBX domain DAO PF01266.19 EDK41381.1 - 6.6e-52 176.5 0.0 8.3e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK41381.1 - 3.9e-14 52.3 0.9 9.1e-14 51.1 0.6 1.5 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 EDK41381.1 - 1.1e-11 44.5 1.1 4.6e-07 29.2 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EDK41381.1 - 6.8e-06 26.1 0.3 0.00057 19.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 EDK41381.1 - 8.3e-05 21.7 0.9 0.1 11.6 0.0 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.17 EDK41381.1 - 0.00021 20.2 0.4 0.011 14.6 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.9 EDK41381.1 - 0.0017 16.9 0.6 0.0034 15.9 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.14 EDK41381.1 - 0.0031 16.6 0.7 0.014 14.4 0.5 1.9 1 1 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.13 EDK41381.1 - 0.01 15.4 1.0 0.056 13.0 0.7 2.1 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 EDK41381.1 - 0.014 15.3 0.3 0.036 14.0 0.2 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 EDK41381.1 - 0.017 15.3 0.0 0.06 13.6 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Lycopene_cycl PF05834.7 EDK41381.1 - 0.066 12.1 0.2 0.43 9.4 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Transposase_20 PF02371.11 EDK41381.1 - 0.088 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Amdo_NSP PF12475.3 EDK41384.2 - 0.054 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Amdovirus non-structural protein IFRD PF05004.8 EDK41387.2 - 6.7e-15 54.9 6.2 1.6e-14 53.6 0.0 3.2 2 1 2 4 4 4 2 Interferon-related developmental regulator (IFRD) ORF6C PF10552.4 EDK41387.2 - 0.025 14.3 0.2 0.091 12.5 0.1 1.9 1 0 0 1 1 1 0 ORF6C domain Acetyltransf_1 PF00583.19 EDK41388.2 - 3e-09 36.7 0.0 4.6e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 EDK41388.2 - 1.2e-06 28.1 0.0 2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.1 EDK41388.2 - 0.00044 20.2 0.0 0.00055 19.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK41388.2 - 0.00074 19.6 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK41388.2 - 0.0016 18.5 0.0 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 EDK41388.2 - 0.015 15.1 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain BBS2_Mid PF14783.1 EDK41389.2 - 2.4e-06 27.3 0.4 0.31 10.8 0.0 4.3 3 1 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 EDK41389.2 - 0.004 16.9 0.2 10 6.1 0.0 4.7 6 0 0 6 6 6 1 WD domain, G-beta repeat PQQ_3 PF13570.1 EDK41389.2 - 0.013 15.7 0.0 36 4.8 0.0 4.0 3 0 0 3 3 3 0 PQQ-like domain RAB3GAP2_N PF14655.1 EDK41389.2 - 0.04 12.9 0.0 0.1 11.5 0.0 1.6 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus FGF PF00167.13 EDK41389.2 - 0.16 11.7 0.1 0.4 10.4 0.1 1.6 1 0 0 1 1 1 0 Fibroblast growth factor K_trans PF02705.11 EDK41390.2 - 3.6e-184 613.0 15.4 4.3e-184 612.7 10.7 1.0 1 0 0 1 1 1 1 K+ potassium transporter LSM14 PF12701.2 EDK41391.1 - 2e-29 101.2 0.0 3.3e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.1 EDK41391.1 - 0.0001 22.1 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.5 EDK41391.1 - 0.00012 22.5 4.6 0.093 13.2 0.2 2.4 1 1 1 2 2 2 2 FDF domain TFIIA PF03153.8 EDK41391.1 - 0.015 15.2 7.7 0.018 14.9 5.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit API5 PF05918.6 EDK41391.1 - 0.11 11.0 7.2 0.15 10.5 5.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Med3 PF11593.3 EDK41391.1 - 5.2 6.2 18.8 6.8 5.8 13.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Med26 PF08711.6 EDK41392.2 - 6.3e-12 44.8 0.1 1.3e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ribosom_S12_S23 PF00164.20 EDK41393.1 - 3e-40 136.4 0.3 3.6e-40 136.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Mito_carr PF00153.22 EDK41394.1 - 5.5e-53 176.6 0.1 2.4e-19 68.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.27 EDK41395.2 - 0.00084 19.1 0.5 13 5.8 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat CPSF_A PF03178.10 EDK41395.2 - 0.048 12.7 0.5 0.77 8.7 0.0 2.3 1 1 0 2 2 2 0 CPSF A subunit region PQQ_3 PF13570.1 EDK41395.2 - 0.063 13.5 0.5 11 6.4 0.0 3.4 3 0 0 3 3 3 0 PQQ-like domain DBR1 PF05011.8 EDK41396.2 - 3e-14 53.1 0.0 5.5e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 EDK41396.2 - 1.1e-08 34.7 0.1 1.2e-07 31.3 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 EDK41396.2 - 0.00017 21.4 0.0 0.00051 19.9 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SPOUT_MTase PF02590.12 EDK41396.2 - 0.073 12.7 0.7 0.16 11.6 0.1 1.7 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase NAD_binding_1 PF00175.16 EDK41397.2 - 3.9e-27 94.9 0.0 8.4e-27 93.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 EDK41397.2 - 6.9e-24 83.8 0.0 1.3e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 EDK41397.2 - 6.1e-07 29.4 0.1 0.00021 21.2 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Carb_kinase PF01256.12 EDK41398.2 - 3e-54 183.8 1.2 4.7e-53 179.9 0.8 2.0 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.7 EDK41398.2 - 0.0003 20.0 0.0 0.0005 19.3 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase NAD_Gly3P_dh_N PF01210.18 EDK41400.1 - 2.4e-52 176.8 0.1 4.1e-52 176.0 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 EDK41400.1 - 2e-41 141.2 0.1 3.3e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.12 EDK41400.1 - 0.0031 17.8 0.1 0.095 13.1 0.0 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NUDIX PF00293.23 EDK41401.2 - 1e-14 54.3 0.0 2.1e-14 53.2 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain PA26 PF04636.8 EDK41402.2 - 0.46 9.1 2.8 0.6 8.7 1.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Brix PF04427.13 EDK41403.2 - 1.2e-59 201.1 4.1 1.9e-59 200.5 2.8 1.2 1 0 0 1 1 1 1 Brix domain TFIIA PF03153.8 EDK41403.2 - 0.05 13.5 10.6 0.072 12.9 7.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DEAD PF00270.24 EDK41404.2 - 1.8e-48 164.2 0.3 2.7e-47 160.3 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK41404.2 - 7.1e-28 96.2 0.0 1.7e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK41404.2 - 1.2e-06 28.5 0.8 1.5e-05 24.8 0.0 2.9 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 EDK41404.2 - 0.015 15.0 0.2 0.18 11.5 0.0 2.8 3 0 0 3 3 3 0 Part of AAA domain FYVE PF01363.16 EDK41405.2 - 2.6e-18 65.6 10.7 2.6e-18 65.6 7.4 3.2 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 EDK41405.2 - 1e-11 44.4 2.0 1e-11 44.4 1.4 3.7 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 EDK41405.2 - 3.1e-05 23.8 23.7 3.3e-05 23.8 2.2 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK41405.2 - 0.00054 19.5 1.3 0.00054 19.5 0.9 4.2 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 EDK41405.2 - 0.0028 17.7 2.9 0.0028 17.7 2.0 3.5 3 1 0 3 3 3 1 RING-H2 zinc finger RINGv PF12906.2 EDK41405.2 - 0.046 13.7 2.2 0.046 13.7 1.5 3.0 3 0 0 3 3 2 0 RING-variant domain zf-RING_UBOX PF13445.1 EDK41405.2 - 0.047 13.3 1.4 0.047 13.3 1.0 2.7 3 0 0 3 3 3 0 RING-type zinc-finger zf-Di19 PF05605.7 EDK41405.2 - 0.071 13.2 3.7 1.6 8.8 0.0 2.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-HC5HC2H PF13771.1 EDK41405.2 - 0.073 13.2 0.1 0.073 13.2 0.1 3.1 3 0 0 3 3 3 0 PHD-like zinc-binding domain FdhE PF04216.7 EDK41405.2 - 0.38 10.4 12.5 5.2 6.6 0.0 2.3 1 1 1 2 2 2 0 Protein involved in formate dehydrogenase formation SCP1201-deam PF14428.1 EDK41405.2 - 0.94 9.1 3.8 0.56 9.9 0.2 2.2 2 1 0 2 2 2 0 SCP1.201-like deaminase Med21 PF11221.3 EDK41406.2 - 7.9e-52 175.0 6.9 1.1e-51 174.6 4.8 1.2 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Spore_III_AB PF09548.5 EDK41406.2 - 0.002 17.8 1.1 0.0044 16.7 0.5 1.7 2 0 0 2 2 2 1 Stage III sporulation protein AB (spore_III_AB) Sipho_Gp157 PF05565.6 EDK41406.2 - 0.039 13.5 1.7 0.059 12.9 1.2 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 NYD-SP28 PF14772.1 EDK41406.2 - 4 7.5 9.4 1.1 9.3 3.5 2.1 3 0 0 3 3 3 0 Sperm tail PMT PF02366.13 EDK41407.2 - 4.8e-54 183.3 12.2 4.8e-54 183.3 8.5 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 EDK41407.2 - 6.4e-28 97.5 0.1 9.1e-28 97.0 0.1 1.2 1 0 0 1 1 1 1 MIR domain DUF1329 PF07044.6 EDK41407.2 - 0.052 12.4 0.4 0.098 11.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1329) Ins145_P3_rec PF08709.6 EDK41407.2 - 0.18 10.7 0.0 0.38 9.7 0.0 1.4 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor F-box-like PF12937.2 EDK41408.2 - 0.029 14.0 0.1 0.053 13.2 0.1 1.5 1 0 0 1 1 1 0 F-box-like DUF3760 PF12586.3 EDK41408.2 - 0.065 13.0 0.0 0.74 9.6 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3760) LRR_8 PF13855.1 EDK41408.2 - 0.25 11.1 3.6 2.4 7.9 0.5 3.6 5 0 0 5 5 5 0 Leucine rich repeat ApoO PF09769.4 EDK41410.2 - 5.1e-48 162.7 0.9 2.1e-47 160.7 0.1 1.9 2 0 0 2 2 2 1 Apolipoprotein O Imm3 PF14425.1 EDK41410.2 - 0.038 13.9 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Immunity protein Imm3 OEP PF02321.13 EDK41410.2 - 0.073 12.6 0.3 0.77 9.3 0.0 2.1 2 0 0 2 2 2 0 Outer membrane efflux protein BCAS2 PF05700.6 EDK41410.2 - 0.075 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Rsm22 PF09243.5 EDK41411.2 - 2.9e-23 82.2 3.1 8.4e-08 31.5 0.0 4.3 4 0 0 4 4 4 4 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_12 PF08242.7 EDK41411.2 - 0.011 16.1 0.0 0.2 12.1 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain Trypan_PARP PF05887.6 EDK41411.2 - 0.75 9.6 19.4 0.015 15.1 3.7 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) EzrA PF06160.7 EDK41412.2 - 0.011 13.9 6.2 0.017 13.3 0.9 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Mito_carr PF00153.22 EDK41413.2 - 1.2e-60 201.1 0.4 1.1e-22 79.5 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Raptor_N PF14538.1 EDK41414.2 - 2.9e-67 225.3 0.0 5.5e-67 224.4 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.27 EDK41414.2 - 1.3e-09 37.5 7.4 0.47 10.4 0.0 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat HEAT PF02985.17 EDK41414.2 - 1e-06 28.3 0.3 0.19 11.8 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.2 EDK41414.2 - 0.00033 20.5 0.0 0.7 9.7 0.0 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 EDK41414.2 - 0.0021 18.2 0.0 0.43 10.8 0.0 3.3 1 1 2 3 3 3 2 HEAT repeats CLASP_N PF12348.3 EDK41414.2 - 0.049 12.9 0.0 0.27 10.5 0.0 2.2 2 0 0 2 2 2 0 CLASP N terminal CDO_I PF05995.7 EDK41415.2 - 1.1e-37 128.9 0.0 1.4e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I DUF1637 PF07847.7 EDK41415.2 - 0.003 16.9 0.9 0.024 14.0 0.6 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1637) SLAC1 PF03595.12 EDK41416.2 - 7.1e-87 291.1 44.5 9.4e-87 290.7 30.9 1.2 1 0 0 1 1 1 1 Voltage-dependent anion channel Trs65 PF12735.2 EDK41417.2 - 5.5e-82 275.5 6.7 5.5e-82 275.5 4.7 2.0 2 0 0 2 2 2 1 TRAPP trafficking subunit Trs65 Act-Frag_cataly PF09192.5 EDK41418.2 - 0.021 13.7 0.2 0.05 12.5 0.1 1.5 1 1 1 2 2 2 0 Actin-fragmin kinase, catalytic Laminin_EGF PF00053.19 EDK41418.2 - 0.055 13.3 0.2 0.088 12.7 0.1 1.2 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) DUF4451 PF14616.1 EDK41419.2 - 2.4e-36 124.2 0.6 5.9e-36 122.9 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) DUF1986 PF09342.6 EDK41419.2 - 0.011 15.0 0.3 0.02 14.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) zf-Di19 PF05605.7 EDK41419.2 - 0.14 12.3 7.5 5.7 7.1 0.1 3.0 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding tRNA-synt_2b PF00587.20 EDK41420.2 - 1.7e-67 226.3 0.2 4.1e-67 225.0 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EDK41420.2 - 6.4e-21 74.1 0.3 2e-20 72.5 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain Pyr_redox_3 PF13738.1 EDK41421.2 - 4.6e-18 66.0 0.1 1.5e-17 64.3 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EDK41421.2 - 5.8e-16 57.7 2.9 1.3e-14 53.3 2.0 2.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EDK41421.2 - 2.9e-10 40.0 0.0 7.4e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EDK41421.2 - 4.5e-10 38.9 0.2 3.1e-07 29.6 0.1 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EDK41421.2 - 6.2e-05 22.9 0.0 0.00024 21.0 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK41421.2 - 0.00024 20.9 0.0 0.043 13.5 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 EDK41421.2 - 0.00042 19.4 0.1 0.0045 16.0 0.0 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 EDK41421.2 - 0.00066 18.6 0.1 0.46 9.3 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK41421.2 - 0.0019 17.0 0.0 0.004 16.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.15 EDK41421.2 - 0.0046 17.0 0.1 2.2 8.3 0.0 2.9 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase GIDA PF01134.17 EDK41421.2 - 0.094 11.5 0.0 0.8 8.4 0.0 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A HI0933_like PF03486.9 EDK41421.2 - 0.095 11.1 0.1 0.16 10.3 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.1 EDK41422.2 - 5.6e-15 55.9 0.0 4.7e-14 52.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 EDK41422.2 - 3.6e-10 38.6 0.1 7.7e-06 24.3 0.0 3.1 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.1 EDK41422.2 - 3e-09 36.7 0.0 1e-08 35.0 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 EDK41422.2 - 7.1e-08 31.7 0.1 2.3e-06 26.8 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.9 EDK41422.2 - 1.4e-05 25.0 0.0 2.5e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 EDK41422.2 - 1.8e-05 24.5 0.0 0.0099 15.6 0.0 3.8 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.19 EDK41422.2 - 0.00054 18.9 0.0 0.029 13.2 0.0 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 EDK41422.2 - 0.0044 15.9 0.0 0.096 11.5 0.0 2.7 3 1 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.12 EDK41422.2 - 0.0046 16.0 0.5 0.13 11.2 0.0 2.7 3 0 0 3 3 3 1 Thi4 family FAD_binding_2 PF00890.19 EDK41422.2 - 0.0055 15.5 0.0 0.0093 14.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Spermine_synth PF01564.12 EDK41422.2 - 0.011 14.6 0.0 0.74 8.6 0.0 2.3 2 0 0 2 2 2 0 Spermine/spermidine synthase GIDA PF01134.17 EDK41422.2 - 0.014 14.2 0.1 1.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.15 EDK41422.2 - 0.035 14.2 0.2 0.44 10.6 0.0 2.5 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.2 EDK41422.2 - 0.061 12.4 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.22 EDK41422.2 - 0.091 13.1 0.0 3.1 8.2 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ABA_GPCR PF12430.3 EDK41423.2 - 2.2e-55 186.8 5.9 2.2e-55 186.8 4.1 2.2 2 1 0 2 2 2 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 EDK41423.2 - 4.9e-20 71.3 1.4 1.4e-19 69.8 0.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3735) BRCT PF00533.21 EDK41423.2 - 0.011 15.8 0.0 0.27 11.3 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Mhr1 PF12829.2 EDK41424.2 - 7.5e-36 121.8 1.7 1.7e-35 120.7 1.2 1.6 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Fungal_trans PF04082.13 EDK41425.2 - 1.4e-12 47.0 10.4 3.1e-12 45.9 7.2 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41425.2 - 6.8e-07 29.1 15.2 1.2e-06 28.2 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.24 EDK41426.2 - 2.5e-40 137.7 0.0 4.4e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41426.2 - 4.6e-06 26.7 0.0 0.00089 19.4 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 EDK41426.2 - 2.4e-05 24.0 0.0 0.00011 21.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EDK41426.2 - 0.00012 22.0 0.0 0.00041 20.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 EDK41426.2 - 0.00033 20.6 0.0 0.00063 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 EDK41426.2 - 0.00065 18.6 0.0 0.0012 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 EDK41426.2 - 0.0013 19.5 0.1 0.0031 18.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK41426.2 - 0.005 16.5 0.1 0.011 15.4 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 EDK41426.2 - 0.0054 15.8 0.0 0.0091 15.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 EDK41426.2 - 0.0088 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 EDK41426.2 - 0.012 14.7 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 EDK41426.2 - 0.016 15.0 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 EDK41426.2 - 0.024 14.5 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 EDK41426.2 - 0.024 14.9 0.0 0.058 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 EDK41426.2 - 0.025 14.2 0.0 4.5 6.9 0.0 2.4 1 1 1 2 2 2 0 Archaeal ATPase IstB_IS21 PF01695.12 EDK41426.2 - 0.029 13.7 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 EDK41426.2 - 0.03 14.4 0.0 0.068 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.1 EDK41426.2 - 0.034 14.2 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 EDK41426.2 - 0.034 13.3 0.0 0.09 11.9 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 EDK41426.2 - 0.034 13.7 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 EDK41426.2 - 0.039 12.6 0.0 0.065 11.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 EDK41426.2 - 0.084 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 EDK41426.2 - 0.14 11.6 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_pol_Rbc25 PF08292.7 EDK41428.2 - 3.7e-43 146.5 0.8 5.3e-43 146.1 0.6 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 EDK41428.2 - 6.4e-19 67.8 0.0 1.1e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RRM_1 PF00076.17 EDK41429.1 - 4.7e-20 70.9 0.0 7e-20 70.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK41429.1 - 4.6e-10 39.3 0.0 6.9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK41429.1 - 0.014 15.2 0.0 0.051 13.4 0.0 2.0 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DctQ PF04290.7 EDK41430.2 - 0.058 13.1 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUSP PF06337.7 EDK41432.2 - 0.94 9.9 6.0 2.9 8.3 4.2 2.0 1 1 0 1 1 1 0 DUSP domain CUE PF02845.11 EDK41433.2 - 1.4e-10 40.4 0.0 2.3e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 CUE domain CbiG_mid PF11761.3 EDK41433.2 - 0.012 15.8 0.2 0.052 13.7 0.2 2.1 1 0 0 1 1 1 0 Cobalamin biosynthesis central region Pneumo_att_G PF05539.6 EDK41433.2 - 6.7 5.9 12.3 12 5.1 8.6 1.4 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G GATA PF00320.22 EDK41435.2 - 6.6e-13 47.7 3.0 2.1e-12 46.1 1.8 1.9 2 0 0 2 2 2 1 GATA zinc finger Hydrolase_6 PF13344.1 EDK41436.2 - 4.6e-24 84.2 0.0 7.8e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 EDK41436.2 - 0.0029 18.0 0.0 0.0065 16.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EDK41436.2 - 0.076 13.2 0.2 2.1 8.5 0.0 2.2 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase TP_methylase PF00590.15 EDK41437.2 - 7.3e-42 143.4 0.2 1.8e-41 142.1 0.0 1.7 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 EDK41437.2 - 1e-11 44.9 0.0 2.1e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 EDK41437.2 - 0.00064 18.9 0.2 1.5 8.2 0.0 3.2 4 0 0 4 4 4 2 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 EDK41437.2 - 0.012 14.5 0.0 0.026 13.4 0.0 1.6 1 0 0 1 1 1 0 Sirohaem biosynthesis protein central Nro1 PF12753.2 EDK41438.2 - 2.6e-161 537.0 27.8 2.9e-161 536.9 19.3 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 TPR_11 PF13414.1 EDK41438.2 - 0.0003 20.3 2.9 0.021 14.4 0.0 3.8 4 1 0 4 4 4 1 TPR repeat TPR_19 PF14559.1 EDK41438.2 - 0.00053 20.2 10.6 0.0045 17.3 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 EDK41438.2 - 0.0015 18.9 1.3 4.4 8.2 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 EDK41438.2 - 0.0052 17.4 3.6 0.56 10.9 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat AnfO_nitrog PF09582.5 EDK41438.2 - 0.087 11.9 2.5 0.22 10.6 1.3 2.0 1 1 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) TPR_1 PF00515.23 EDK41438.2 - 0.38 10.4 5.8 17 5.1 0.5 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat eIF3_p135 PF12807.2 EDK41438.2 - 1.1 9.1 5.6 0.3 10.9 0.8 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 zf-AN1 PF01428.11 EDK41439.2 - 6.1e-10 38.8 9.8 1.6e-09 37.4 6.8 1.8 1 0 0 1 1 1 1 AN1-like Zinc finger ubiquitin PF00240.18 EDK41439.2 - 0.00048 19.4 0.0 0.0012 18.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin family Calc_CGRP_IAPP PF00214.14 EDK41439.2 - 0.095 12.7 3.0 2.5 8.1 0.4 2.4 2 0 0 2 2 2 0 Calcitonin / CGRP / IAPP family Acyltransferase PF01553.16 EDK41440.2 - 1.1e-09 37.8 0.0 1.1e-08 34.5 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase TRAPP PF04051.11 EDK41441.1 - 7.6e-28 96.9 0.0 8.6e-28 96.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component FA_hydroxylase PF04116.8 EDK41442.1 - 4.5e-17 62.4 5.4 4.5e-17 62.4 3.7 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Tenui_N PF05733.6 EDK41442.1 - 0.081 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Tenuivirus/Phlebovirus nucleocapsid protein ABC2_membrane_2 PF12679.2 EDK41443.1 - 0.0001 21.2 2.0 0.00023 20.1 0.0 2.0 1 1 0 2 2 2 1 ABC-2 family transporter protein Gate PF07670.9 EDK41443.1 - 1.3 8.9 8.6 1.4 8.8 0.1 2.6 1 1 1 2 2 2 0 Nucleoside recognition Methyltransf_11 PF08241.7 EDK41444.2 - 2e-16 60.2 0.0 3.5e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK41444.2 - 6.1e-12 45.7 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK41444.2 - 3.8e-11 42.7 0.0 5.8e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK41444.2 - 3.7e-10 40.1 0.0 7.4e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK41444.2 - 7.9e-09 35.4 0.0 1.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK41444.2 - 1.1e-07 32.4 0.0 2e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 EDK41444.2 - 4.8e-07 29.1 0.0 8.8e-07 28.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 EDK41444.2 - 6.4e-05 22.3 0.0 0.00016 21.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 EDK41444.2 - 0.00018 21.4 0.0 0.00056 19.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 EDK41444.2 - 0.0019 16.9 0.0 0.0029 16.3 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase CMAS PF02353.15 EDK41444.2 - 0.0049 15.9 0.0 0.022 13.8 0.0 2.0 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.1 EDK41444.2 - 0.0071 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 EDK41444.2 - 0.0075 15.3 0.0 0.068 12.2 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase DREV PF05219.7 EDK41444.2 - 0.0076 15.1 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_15 PF09445.5 EDK41444.2 - 0.022 14.3 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_PK PF05891.7 EDK41444.2 - 0.023 14.0 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase PrmA PF06325.8 EDK41444.2 - 0.056 12.5 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pirin PF02678.11 EDK41445.1 - 9.7e-29 99.3 0.3 1.6e-28 98.6 0.2 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 EDK41445.1 - 4.3e-22 78.1 0.0 8.4e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 EDK41445.1 - 8.6e-05 21.9 0.6 0.14 11.6 0.0 2.4 2 0 0 2 2 2 2 Cupin domain CDC27 PF09507.5 EDK41446.2 - 9.8e-26 90.9 26.6 6.3e-22 78.3 10.8 2.2 1 1 1 2 2 2 2 DNA polymerase subunit Cdc27 RRP7 PF12923.2 EDK41446.2 - 0.024 14.6 6.9 0.035 14.1 0.1 2.6 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) ALIX_LYPXL_bnd PF13949.1 EDK41447.2 - 0.0019 17.2 0.1 0.0035 16.3 0.1 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF4239 PF14023.1 EDK41447.2 - 0.019 14.3 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) CTK3 PF12243.3 EDK41447.2 - 0.052 13.1 0.1 0.17 11.5 0.0 1.9 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 Angiomotin_C PF12240.3 EDK41447.2 - 0.095 12.1 0.3 0.2 11.1 0.2 1.5 1 0 0 1 1 1 0 Angiomotin C terminal FA_desaturase PF00487.19 EDK41450.2 - 0.096 12.1 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Fatty acid desaturase ADH_N PF08240.7 EDK41452.2 - 0.012 15.3 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Peptidase_M20 PF01546.23 EDK41453.2 - 2.2e-23 82.7 0.0 3.4e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 EDK41453.2 - 7.9e-11 41.6 0.0 1.4e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.27 EDK41453.2 - 6.3e-10 38.5 0.4 0.058 13.2 0.0 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat FA_synthesis PF02504.10 EDK41453.2 - 0.2 10.4 0.0 0.67 8.7 0.0 1.7 2 0 0 2 2 2 0 Fatty acid synthesis protein SPX PF03105.14 EDK41454.2 - 6.7e-48 163.8 16.8 1.1e-47 163.1 11.6 1.4 1 1 0 1 1 1 1 SPX domain AF0941-like PF14591.1 EDK41454.2 - 0.036 14.1 0.9 0.093 12.7 0.5 1.8 2 0 0 2 2 2 0 AF0941-like Nucleoplasmin PF03066.10 EDK41454.2 - 0.72 9.3 7.0 1.8 8.0 4.8 1.6 1 0 0 1 1 1 0 Nucleoplasmin Na_sulph_symp PF00939.14 EDK41455.2 - 1.7e-14 53.5 29.8 9.8e-14 51.0 14.2 2.0 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 EDK41455.2 - 3.1e-08 32.6 34.1 2.9e-05 22.8 6.1 2.1 1 1 1 2 2 2 2 Citrate transporter TMEM164 PF14808.1 EDK41455.2 - 0.03 13.5 2.9 1.5 7.9 0.0 2.6 1 1 1 2 2 2 0 TMEM164 family DUF373 PF04123.8 EDK41455.2 - 8.2 5.3 18.6 0.75 8.7 6.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Sigma70_r1_1 PF03979.9 EDK41456.2 - 0.12 12.3 1.4 11 6.0 0.0 3.1 3 0 0 3 3 3 0 Sigma-70 factor, region 1.1 UPF0118 PF01594.11 EDK41456.2 - 0.3 10.0 2.4 0.18 10.7 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF20 POM121 PF15229.1 EDK41457.2 - 0.0095 15.3 0.5 0.013 14.9 0.4 1.1 1 0 0 1 1 1 1 POM121 family Apt1 PF10351.4 EDK41457.2 - 0.094 11.5 0.7 0.15 10.9 0.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PI3_PI4_kinase PF00454.22 EDK41458.2 - 2.5e-43 148.2 0.0 3.5e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ApbA_C PF08546.6 EDK41459.2 - 1.8e-29 102.2 0.0 3.4e-29 101.3 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 EDK41459.2 - 2.3e-24 85.5 0.0 3.1e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.22 EDK41459.2 - 0.0061 16.9 0.2 0.019 15.3 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 EDK41459.2 - 0.091 12.5 0.3 1.3 8.8 0.1 2.3 2 0 0 2 2 2 0 ThiF family FAD_binding_3 PF01494.14 EDK41459.2 - 0.16 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.19 EDK41459.2 - 0.16 10.8 0.6 0.24 10.2 0.4 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Phos_pyr_kin PF08543.7 EDK41460.1 - 5.2e-15 55.3 0.0 7.1e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 EDK41460.1 - 1.7e-08 34.0 0.0 3.2e-08 33.0 0.0 1.5 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Endonuc-FokI_C PF09254.6 EDK41460.1 - 0.02 13.9 0.0 0.048 12.7 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal V-set_CD47 PF08204.6 EDK41460.1 - 0.081 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain TIG PF01833.19 EDK41461.2 - 1.4e-11 44.2 3.1 2.9e-11 43.2 0.4 2.7 2 0 0 2 2 2 1 IPT/TIG domain Ank PF00023.25 EDK41461.2 - 3.5e-11 42.3 0.0 2.5e-05 23.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 EDK41461.2 - 4.8e-08 33.2 0.0 1.3e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 EDK41461.2 - 6.7e-07 29.6 0.1 2.4e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 EDK41461.2 - 8e-06 25.9 0.0 2.7e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 EDK41461.2 - 0.00051 20.0 0.0 0.48 10.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat HEM4 PF02602.10 EDK41462.2 - 3.1e-42 144.4 0.0 3.5e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD AMP-binding PF00501.23 EDK41463.2 - 6.9e-90 301.4 0.0 8.5e-90 301.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 EDK41463.2 - 6.8e-19 68.5 0.5 1.4e-17 64.3 0.2 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain OPA3 PF07047.7 EDK41464.2 - 1.9e-35 121.5 1.5 1.9e-35 121.5 1.1 1.6 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Histone PF00125.19 EDK41465.1 - 5.8e-22 77.5 0.1 7.4e-22 77.2 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 EDK41465.1 - 0.00089 19.2 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NPR2 PF06218.6 EDK41466.2 - 6.4e-187 621.4 1.3 9e-187 620.9 0.4 1.5 2 0 0 2 2 2 1 Nitrogen permease regulator 2 NPR3 PF03666.8 EDK41466.2 - 0.00045 18.8 0.4 0.85 8.0 0.1 2.9 1 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 CI-B14_5a PF07347.7 EDK41466.2 - 0.06 13.1 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Cpn60_TCP1 PF00118.19 EDK41467.2 - 4.9e-116 388.2 9.2 5.7e-116 388.0 6.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rrf2 PF02082.15 EDK41467.2 - 0.074 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator RNA_pol_I_TF PF04090.7 EDK41468.2 - 5.5e-73 244.4 0.2 1.1e-72 243.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor Heme_oxygenase PF01126.15 EDK41468.2 - 0.06 12.8 2.1 0.87 9.1 0.0 2.2 2 0 0 2 2 2 0 Heme oxygenase DUF1010 PF06231.6 EDK41468.2 - 0.14 12.2 1.3 0.28 11.2 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) YaaC PF14175.1 EDK41468.2 - 3.9 6.3 11.3 0.68 8.8 5.0 1.7 2 0 0 2 2 2 0 YaaC-like Protein zf-rbx1 PF12678.2 EDK41469.2 - 4.9e-11 42.5 0.2 8.8e-11 41.7 0.2 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 EDK41469.2 - 2.8e-10 39.8 3.6 6.9e-10 38.6 2.5 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 EDK41469.2 - 6.6e-06 25.6 4.5 7.6e-05 22.3 3.4 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 EDK41469.2 - 5.7e-05 22.6 2.0 0.00012 21.6 1.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 EDK41469.2 - 0.00011 21.8 1.0 0.00021 20.9 0.7 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 EDK41469.2 - 0.00013 21.9 1.1 0.00013 21.9 0.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 EDK41469.2 - 0.00089 19.0 2.0 0.0029 17.3 1.4 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 EDK41469.2 - 0.0018 17.9 0.2 0.005 16.5 0.2 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 EDK41469.2 - 0.012 15.4 0.7 0.031 14.1 0.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 EDK41469.2 - 0.16 11.9 3.0 0.83 9.6 2.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 EDK41469.2 - 0.23 11.5 3.3 0.76 9.8 2.3 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 EDK41469.2 - 0.28 10.7 2.2 0.4 10.2 0.5 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Kinesin PF00225.18 EDK41470.2 - 1.5e-102 342.7 4.0 1.5e-102 342.7 2.8 2.5 2 0 0 2 2 2 1 Kinesin motor domain dsDNA_bind PF01984.15 EDK41471.2 - 3.6e-30 104.1 1.2 4.3e-30 103.8 0.8 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain bact-PGI_C PF10432.4 EDK41471.2 - 0.022 14.4 0.2 0.028 14.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal region Ras PF00071.17 EDK41472.2 - 6.9e-46 155.5 0.2 7.8e-46 155.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 EDK41472.2 - 3.4e-10 40.4 0.0 4.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK41472.2 - 2.7e-08 33.2 0.3 3.2e-08 33.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK41472.2 - 0.00014 21.3 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 EDK41472.2 - 0.018 14.1 0.2 0.023 13.8 0.1 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region zf-C2H2 PF00096.21 EDK41473.2 - 3.2e-12 46.0 13.0 9.4e-06 25.6 2.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 EDK41473.2 - 1.4e-10 40.6 11.4 4e-05 23.6 2.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 EDK41473.2 - 7.7e-10 38.5 4.8 7.7e-10 38.5 3.3 3.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_6 PF13912.1 EDK41473.2 - 4.7e-08 32.6 3.2 1.4e-07 31.1 0.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.2 EDK41473.2 - 0.0011 19.0 4.3 0.78 10.0 0.5 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-Di19 PF05605.7 EDK41473.2 - 0.0035 17.4 1.1 0.0035 17.4 0.8 2.1 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 EDK41473.2 - 0.021 14.9 0.6 0.021 14.9 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.6 EDK41473.2 - 0.31 10.7 1.5 5.2 6.8 0.3 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-H2C2_5 PF13909.1 EDK41473.2 - 1.4 9.2 7.5 3.2 8.1 1.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain GAGA PF09237.6 EDK41473.2 - 2.2 7.9 6.3 0.81 9.3 1.3 2.4 2 1 1 3 3 3 0 GAGA factor MFS_1 PF07690.11 EDK41474.2 - 1.7e-30 105.9 27.7 1.7e-30 105.9 19.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3082 PF11282.3 EDK41474.2 - 0.045 13.8 3.3 13 5.9 0.1 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3082) RPW8 PF05659.6 EDK41475.2 - 0.028 13.9 1.5 0.056 12.9 0.0 2.2 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Metallophos PF00149.23 EDK41476.2 - 1.5e-39 135.5 0.0 2.2e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Methyltransf_23 PF13489.1 EDK41476.2 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Acetyltransf_1 PF00583.19 EDK41477.2 - 1.5e-08 34.5 0.0 2.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 EDK41477.2 - 6e-08 32.7 0.0 1.2e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 EDK41477.2 - 7e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 EDK41477.2 - 0.0008 19.2 0.0 0.0026 17.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 EDK41477.2 - 0.0045 17.1 0.0 0.012 15.7 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 EDK41477.2 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.1 EDK41477.2 - 0.13 12.4 0.0 0.28 11.3 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Methyltransf_28 PF02636.12 EDK41478.2 - 1.6e-79 266.8 0.0 2.2e-79 266.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Syntaxin PF00804.20 EDK41478.2 - 0.14 12.3 0.5 0.28 11.3 0.4 1.5 1 0 0 1 1 1 0 Syntaxin LCM PF04072.9 EDK41479.2 - 8.8e-24 84.0 0.0 1.5e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase ArdA PF07275.6 EDK41479.2 - 0.023 14.9 0.0 0.061 13.5 0.0 1.7 1 0 0 1 1 1 0 Antirestriction protein (ArdA) Methyltransf_11 PF08241.7 EDK41480.2 - 2e-11 44.2 0.0 3.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK41480.2 - 2e-09 37.2 0.0 2.7e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 EDK41480.2 - 9.9e-06 25.3 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK41480.2 - 3.4e-05 24.2 0.0 5.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK41480.2 - 0.00027 21.4 0.0 0.00048 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK41480.2 - 0.00063 20.0 0.0 0.0012 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 EDK41480.2 - 0.0028 16.4 0.0 0.0041 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MAP65_ASE1 PF03999.7 EDK41481.2 - 0.032 12.8 0.5 0.05 12.2 0.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TAFII28 PF04719.9 EDK41482.2 - 4.2e-22 77.7 0.2 5.1e-20 71.0 0.2 2.3 2 0 0 2 2 2 2 hTAFII28-like protein conserved region Catalase PF00199.14 EDK41483.2 - 6.6e-162 538.5 0.0 8e-162 538.2 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 EDK41483.2 - 4.3e-11 42.4 0.0 2.4e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive 4HBT PF03061.17 EDK41484.2 - 0.095 12.8 0.0 2 8.5 0.0 2.5 2 0 0 2 2 2 0 Thioesterase superfamily SET PF00856.23 EDK41485.2 - 1.3e-14 54.8 0.0 1.5e-13 51.3 0.0 2.2 1 1 0 1 1 1 1 SET domain HTH_21 PF13276.1 EDK41485.2 - 1.3e-05 25.1 0.0 2.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 HTH-like domain SAF PF08666.7 EDK41485.2 - 0.092 13.1 0.0 3 8.3 0.0 2.3 2 0 0 2 2 2 0 SAF domain 5-FTHF_cyc-lig PF01812.15 EDK41486.2 - 5.7e-35 120.7 0.0 6.6e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Cyt-b5 PF00173.23 EDK41487.2 - 1.4e-22 79.2 0.0 1.9e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UCH PF00443.24 EDK41489.2 - 3e-05 23.2 4.1 3.2e-05 23.1 2.5 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 EDK41489.2 - 0.0032 16.9 0.1 0.0042 16.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.24 EDK41490.2 - 3.5e-16 59.1 6.2 7.1e-16 58.1 1.3 2.0 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Nitr_red_assoc PF09655.5 EDK41490.2 - 0.045 14.0 0.1 0.096 13.0 0.1 1.6 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) SPX PF03105.14 EDK41491.2 - 1.4e-48 166.0 2.6 2e-48 165.5 1.8 1.3 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 EDK41491.2 - 1.6e-26 93.2 40.8 2.4e-26 92.6 28.3 1.3 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 EDK41491.2 - 5.8e-10 38.2 23.1 5.8e-10 38.2 16.0 2.2 1 1 1 2 2 2 1 Citrate transporter NnrU PF07298.6 EDK41492.2 - 0.33 10.2 5.2 0.21 10.9 0.2 2.5 2 1 1 3 3 3 0 NnrU protein DUF788 PF05620.6 EDK41493.2 - 1.1e-11 44.9 0.0 1.4e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF788) BolA PF01722.13 EDK41494.2 - 3.2e-31 107.1 1.0 5.1e-31 106.4 0.7 1.3 1 0 0 1 1 1 1 BolA-like protein Myosin_head PF00063.16 EDK41495.2 - 2.5e-258 858.7 5.3 2.5e-258 858.7 3.6 2.2 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 EDK41495.2 - 3.5e-34 116.8 0.3 1.7e-33 114.6 0.2 2.4 1 0 0 1 1 1 1 DIL domain IQ PF00612.22 EDK41495.2 - 7.5e-17 59.2 27.7 2.4e-05 23.5 0.1 6.7 7 0 0 7 7 7 5 IQ calmodulin-binding motif AAA_22 PF13401.1 EDK41495.2 - 0.00076 19.6 0.0 0.0069 16.5 0.0 2.7 1 0 0 1 1 1 1 AAA domain Myosin_N PF02736.14 EDK41495.2 - 0.0014 18.2 0.2 0.0036 16.9 0.1 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ABC_tran PF00005.22 EDK41495.2 - 0.019 15.2 4.0 0.12 12.6 0.0 3.0 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.1 EDK41495.2 - 0.064 13.2 2.9 0.34 10.8 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 EDK41495.2 - 0.11 12.2 0.0 0.37 10.5 0.0 1.9 1 0 0 1 1 1 0 Part of AAA domain ADIP PF11559.3 EDK41495.2 - 3.3 7.5 35.2 0.023 14.6 8.9 4.0 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding IFT57 PF10498.4 EDK41495.2 - 3.9 6.1 33.1 0.21 10.3 18.6 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF948 PF06103.6 EDK41495.2 - 4.6 7.1 13.7 1.6 8.6 2.4 3.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FMN_dh PF01070.13 EDK41496.2 - 3.7e-114 381.3 0.1 4.8e-114 380.9 0.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 EDK41496.2 - 7e-26 89.8 0.1 1.8e-25 88.5 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 EDK41496.2 - 8e-07 28.2 0.0 1.4e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 EDK41496.2 - 0.00075 18.4 0.0 0.0015 17.5 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.16 EDK41496.2 - 0.021 14.1 0.0 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.9 EDK41496.2 - 0.11 11.4 0.0 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Copper-fist PF00649.13 EDK41497.2 - 1.7e-21 75.1 0.7 1.7e-21 75.1 0.5 2.5 1 1 1 2 2 2 1 Copper fist DNA binding domain VESA1_N PF12785.2 EDK41497.2 - 0.036 13.0 11.7 0.047 12.6 8.1 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Ran-binding PF05508.6 EDK41498.2 - 3.9e-109 364.2 1.9 5.2e-109 363.8 1.3 1.1 1 0 0 1 1 1 1 RanGTP-binding protein RNA_pol_Rpo13 PF12136.3 EDK41498.2 - 0.016 14.9 0.1 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain SNF2_N PF00176.18 EDK41499.2 - 9.3e-67 224.9 0.0 1.2e-66 224.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 EDK41499.2 - 2.2e-55 187.4 1.4 3.8e-55 186.7 0.9 1.4 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.26 EDK41499.2 - 2.4e-13 49.7 0.0 4.9e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 EDK41499.2 - 1.6e-08 33.7 0.0 8.2e-08 31.4 0.0 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 EDK41499.2 - 0.00013 21.4 0.0 0.00054 19.4 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 EDK41499.2 - 0.0035 17.1 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit FAD_binding_2 PF00890.19 EDK41501.2 - 3.3e-83 279.8 0.0 5e-83 279.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 EDK41501.2 - 1.8e-22 78.8 0.1 1.1e-20 73.1 0.0 3.0 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 EDK41501.2 - 1.8e-13 50.1 0.0 4e-12 45.7 0.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 EDK41501.2 - 1.1e-08 34.6 0.1 2.3e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 EDK41501.2 - 1.1e-08 35.2 0.0 3.1e-06 27.2 0.0 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 EDK41501.2 - 1.6e-07 31.2 0.6 9.1e-07 28.8 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EDK41501.2 - 5.3e-06 25.1 3.0 0.00046 18.7 0.1 2.9 3 1 0 3 3 3 2 HI0933-like protein GIDA PF01134.17 EDK41501.2 - 2e-05 23.6 0.4 0.00022 20.2 0.0 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 EDK41501.2 - 0.0024 17.0 0.3 0.0039 16.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 EDK41501.2 - 0.0053 15.8 0.1 0.19 10.8 0.0 2.8 3 0 0 3 3 3 1 Thi4 family Pyr_redox_3 PF13738.1 EDK41501.2 - 0.0081 16.2 0.4 0.027 14.5 0.3 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HTH_11 PF08279.7 EDK41501.2 - 0.03 13.9 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 HTH domain Streptin-Immun PF11083.3 EDK41501.2 - 0.034 14.1 0.2 0.075 13.0 0.1 1.5 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein AlaDh_PNT_C PF01262.16 EDK41501.2 - 0.075 12.6 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 EDK41501.2 - 0.077 11.8 0.2 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.13 EDK41501.2 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Actin PF00022.14 EDK41502.1 - 1.2e-151 504.6 0.0 1.4e-151 504.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 EDK41502.1 - 0.023 15.0 0.0 0.062 13.6 0.0 1.8 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Phosphodiest PF01663.17 EDK41502.1 - 0.081 12.2 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Synaptobrevin PF00957.16 EDK41503.1 - 9.7e-28 95.6 1.5 1.1e-27 95.4 1.0 1.0 1 0 0 1 1 1 1 Synaptobrevin ODV-E18 PF10717.4 EDK41503.1 - 0.092 12.1 0.2 0.11 11.9 0.2 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 OppC_N PF12911.2 EDK41503.1 - 0.19 11.1 1.0 0.27 10.6 0.7 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C MtrG PF04210.8 EDK41503.1 - 8.9 6.0 6.4 29 4.4 4.4 1.9 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G GCV_H PF01597.14 EDK41504.1 - 1.6e-23 82.6 0.2 2.2e-23 82.2 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 EDK41504.1 - 0.11 12.2 0.0 0.52 9.9 0.0 1.9 2 0 0 2 2 2 0 Biotin-requiring enzyme LicD PF04991.8 EDK41505.2 - 4.8e-36 124.8 1.8 6.2e-36 124.4 0.2 2.0 2 0 0 2 2 2 1 LicD family DUF1870 PF08965.5 EDK41505.2 - 0.087 12.4 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) HSP70 PF00012.15 EDK41506.1 - 9.5e-72 241.7 0.1 1e-71 241.6 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.11 EDK41506.1 - 4.9e-05 23.0 0.0 5.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF1464 PF07318.7 EDK41506.1 - 0.034 12.9 0.0 0.041 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) HSP70 PF00012.15 EDK41507.2 - 6.8e-59 199.3 2.0 7.6e-59 199.1 1.4 1.0 1 0 0 1 1 1 1 Hsp70 protein Macoilin PF09726.4 EDK41507.2 - 1.2 7.2 7.3 1.5 6.9 5.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Na_Ca_ex PF01699.19 EDK41508.2 - 1.2e-34 118.9 45.2 2.8e-21 75.5 7.9 3.4 4 0 0 4 4 4 2 Sodium/calcium exchanger protein 3-PAP PF12578.3 EDK41511.2 - 0.055 13.3 0.0 2.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Myotubularin-associated protein Med16 PF11635.3 EDK41512.2 - 8.5e-191 635.7 0.7 1.1e-190 635.4 0.5 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 SHMT PF00464.14 EDK41513.2 - 5.9e-206 683.4 0.1 6.8e-206 683.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 EDK41513.2 - 8.9e-07 28.1 0.0 1.6e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 EDK41513.2 - 0.002 17.3 0.0 0.0029 16.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 EDK41513.2 - 0.0037 16.0 0.0 0.0056 15.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.20 EDK41514.2 - 2.3e-45 154.7 0.0 2.9e-45 154.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41514.2 - 1.6e-20 73.3 0.0 2.1e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 EDK41514.2 - 3.3e-07 29.5 0.0 5.4e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 EDK41514.2 - 2.1e-06 26.9 0.0 3.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 EDK41514.2 - 6.2e-06 26.1 0.2 7.8e-05 22.5 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family DUF2413 PF10310.4 EDK41515.2 - 7.2e-129 430.4 8.9 8.2e-129 430.2 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) DUF1687 PF07955.6 EDK41516.2 - 0.00018 21.4 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) CN_hydrolase PF00795.17 EDK41517.1 - 1.2e-22 80.2 0.0 1.9e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase BCDHK_Adom3 PF10436.4 EDK41518.2 - 7.1e-65 217.5 0.0 1.4e-64 216.5 0.0 1.5 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 EDK41518.2 - 2.7e-15 56.0 0.0 5.3e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 EDK41518.2 - 0.061 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1170 PF06663.8 EDK41518.2 - 0.063 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) Peroxin-13_N PF04088.8 EDK41519.2 - 5.4e-62 208.4 0.8 8.6e-62 207.7 0.6 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.12 EDK41519.2 - 9e-09 34.6 0.0 1.7e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 EDK41519.2 - 2.4e-08 33.4 0.0 4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EDK41519.2 - 3.9e-08 32.5 0.0 6.9e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.6 EDK41519.2 - 0.00077 19.5 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain DUF1192 PF06698.6 EDK41520.1 - 0.0019 17.9 1.1 5.3 6.9 0.0 3.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1192) MT0933_antitox PF14013.1 EDK41520.1 - 0.013 15.6 36.8 0.76 9.9 4.0 4.9 1 1 3 4 4 4 0 MT0933-like antitoxin protein RESP18 PF14948.1 EDK41520.1 - 0.026 14.5 0.1 0.6 10.1 0.0 2.4 1 1 0 2 2 2 0 RESP18 domain Mitofilin PF09731.4 EDK41520.1 - 0.07 11.7 22.5 0.084 11.5 15.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein GAGE PF05831.6 EDK41520.1 - 0.12 12.4 10.6 1.2 9.2 0.1 3.4 1 1 2 3 3 3 0 GAGE protein EspB PF05802.6 EDK41520.1 - 0.12 11.2 25.9 0.98 8.2 10.5 2.1 1 1 1 2 2 2 0 Enterobacterial EspB protein YtxH PF12732.2 EDK41520.1 - 0.12 12.7 28.2 0.14 12.5 3.5 3.9 2 2 1 3 3 3 0 YtxH-like protein ISG65-75 PF11727.3 EDK41520.1 - 0.27 10.2 28.0 0.19 10.7 6.6 2.2 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF883 PF05957.8 EDK41520.1 - 0.39 11.1 19.2 2.5 8.5 3.9 3.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) Tape_meas_lam_C PF09718.5 EDK41520.1 - 0.46 10.4 9.7 8 6.4 1.5 3.5 3 1 1 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) LEA_4 PF02987.11 EDK41520.1 - 0.95 9.3 41.3 0.052 13.4 9.4 4.2 3 2 0 4 4 4 0 Late embryogenesis abundant protein Rifin_STEVOR PF02009.11 EDK41520.1 - 1.9 8.0 17.7 22 4.5 12.3 2.0 1 1 0 1 1 1 0 Rifin/stevor family DUF4200 PF13863.1 EDK41520.1 - 2.2 8.2 8.7 1.6 8.7 2.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ApoC-I PF04691.7 EDK41520.1 - 3.2 7.5 6.3 8.9 6.0 0.5 2.7 2 1 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) SSPI PF14098.1 EDK41520.1 - 5.5 6.9 5.5 4.4 7.2 0.1 3.0 2 1 1 3 3 3 0 Small, acid-soluble spore protein I DUF948 PF06103.6 EDK41520.1 - 9.8 6.1 7.7 9.7 6.1 2.6 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) GDA1_CD39 PF01150.12 EDK41521.2 - 5.8e-105 351.2 0.0 7.6e-105 350.9 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Serglycin PF04360.7 EDK41521.2 - 0.00073 19.2 3.6 0.00073 19.2 2.5 1.6 2 0 0 2 2 2 1 Serglycin DUF3246 PF11596.3 EDK41521.2 - 8 5.6 10.7 19 4.4 7.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) NAD_kinase PF01513.16 EDK41522.2 - 1.3e-73 247.2 0.0 1.9e-73 246.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 EDK41522.2 - 0.11 11.9 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DEAD PF00270.24 EDK41523.2 - 1.5e-47 161.2 0.0 3.7e-46 156.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK41523.2 - 3.6e-27 94.0 0.0 7.7e-27 92.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.1 EDK41523.2 - 0.015 14.3 0.1 0.051 12.6 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.10 EDK41523.2 - 0.034 13.9 0.0 0.083 12.7 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Gly_transf_sug PF04488.10 EDK41524.2 - 1.8e-13 50.7 0.0 3.9e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Isochorismatase PF00857.15 EDK41525.2 - 3.6e-26 92.1 0.1 7.8e-26 91.0 0.1 1.6 1 1 0 1 1 1 1 Isochorismatase family Isy1 PF06246.7 EDK41526.2 - 9e-74 248.0 9.8 1e-73 247.8 6.8 1.0 1 0 0 1 1 1 1 Isy1-like splicing family PTPS PF01242.14 EDK41526.2 - 0.069 12.8 0.0 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase NUC153 PF08159.7 EDK41527.2 - 4.1e-15 55.0 0.9 8.6e-15 54.0 0.6 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 EDK41527.2 - 0.0073 16.1 0.0 0.14 12.0 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF643 PF04867.7 EDK41529.2 - 0.028 14.7 0.5 0.07 13.5 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF643) DUF2065 PF09838.4 EDK41529.2 - 0.074 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) Lyase_1 PF00206.15 EDK41530.2 - 4.2e-101 338.2 0.0 7.8e-101 337.3 0.0 1.4 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.1 EDK41530.2 - 1e-25 89.5 0.0 2.6e-25 88.2 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal tRNA-synt_2 PF00152.15 EDK41531.2 - 5e-75 252.3 0.0 7.3e-75 251.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK41531.2 - 6.8e-11 41.8 0.1 1.4e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.6 EDK41531.2 - 0.059 12.3 0.0 0.096 11.6 0.0 1.3 1 0 0 1 1 1 0 Inositol 1, 3, 4-trisphosphate 5/6-kinase ProRS-C_1 PF09180.6 EDK41532.2 - 3.8e-25 87.5 0.6 9.1e-25 86.3 0.4 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 EDK41532.2 - 9.4e-22 77.4 0.1 1.6e-21 76.6 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 EDK41532.2 - 5.5e-19 67.9 0.1 2.8e-18 65.6 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain tRNA_edit PF04073.10 EDK41532.2 - 2.2e-09 37.2 0.5 4.4e-09 36.2 0.3 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain PHP PF02811.14 EDK41533.2 - 3.2e-15 56.3 0.0 4.9e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 PHP domain TAP42 PF04177.7 EDK41534.2 - 1.1e-98 330.3 7.6 1.2e-98 330.2 5.3 1.0 1 0 0 1 1 1 1 TAP42-like family tRNA-synt_2 PF00152.15 EDK41535.2 - 8.8e-83 277.8 0.0 1.1e-82 277.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 EDK41535.2 - 3e-06 27.0 0.1 7.2e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain zf-Tim10_DDP PF02953.10 EDK41536.1 - 3.2e-21 74.3 5.9 4.2e-21 73.9 4.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Mmp37 PF09139.6 EDK41536.1 - 0.032 13.2 0.4 0.033 13.2 0.3 1.0 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 E_Pc_C PF06752.7 EDK41536.1 - 0.045 13.2 0.3 0.05 13.1 0.2 1.0 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Phasin_2 PF09361.5 EDK41536.1 - 0.048 13.7 0.1 0.15 12.1 0.1 1.7 1 1 1 2 2 2 0 Phasin protein Bromodomain PF00439.20 EDK41537.2 - 8.7e-20 70.4 0.0 2.8e-19 68.8 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Nop14 PF04147.7 EDK41537.2 - 9.8e-06 23.7 24.5 1.3e-05 23.3 17.0 1.1 1 0 0 1 1 1 1 Nop14-like family TFIIF_alpha PF05793.7 EDK41537.2 - 0.00033 19.1 25.9 0.00045 18.7 18.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Daxx PF03344.10 EDK41537.2 - 0.00079 18.0 24.1 0.001 17.6 16.7 1.1 1 0 0 1 1 1 1 Daxx Family CENP-T PF15511.1 EDK41537.2 - 0.0014 17.9 16.0 0.0018 17.5 11.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T DUF605 PF04652.11 EDK41537.2 - 0.0029 17.0 12.4 0.0033 16.8 8.6 1.1 1 0 0 1 1 1 1 Vta1 like MIP-T3 PF10243.4 EDK41537.2 - 0.021 13.2 29.0 0.031 12.7 20.1 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 BUD22 PF09073.5 EDK41537.2 - 0.021 13.8 27.2 0.028 13.5 18.8 1.2 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.9 EDK41537.2 - 0.054 13.0 20.5 0.096 12.2 14.2 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Spore_coat_CotO PF14153.1 EDK41537.2 - 0.1 12.0 22.6 0.17 11.2 15.7 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Astro_capsid PF03115.9 EDK41537.2 - 0.23 9.6 11.2 0.28 9.4 7.7 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor GAGA_bind PF06217.7 EDK41537.2 - 0.36 10.7 10.7 0.53 10.1 7.4 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family RNA_pol_3_Rpc31 PF11705.3 EDK41537.2 - 0.39 10.6 29.8 0.82 9.5 20.6 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RP-C_C PF11800.3 EDK41537.2 - 0.4 10.3 11.9 0.8 9.3 8.3 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF1510 PF07423.6 EDK41537.2 - 0.57 9.5 31.5 0.9 8.8 21.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 EDK41537.2 - 0.63 7.9 26.3 0.29 9.1 16.6 1.5 2 0 0 2 2 2 0 CDC45-like protein Menin PF05053.8 EDK41537.2 - 0.99 7.4 13.3 1.4 7.0 9.2 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.17 EDK41537.2 - 1.8 7.4 6.3 3.1 6.7 4.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.7 EDK41537.2 - 2.2 7.3 28.7 3.7 6.5 19.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SAPS PF04499.10 EDK41537.2 - 2.5 6.6 16.4 0.3 9.6 8.5 1.6 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein FAM60A PF15396.1 EDK41537.2 - 4.6 6.9 7.7 7.9 6.1 5.3 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Hid1 PF12722.2 EDK41537.2 - 6.6 4.2 20.7 5.8 4.4 12.5 1.9 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Paf1 PF03985.8 EDK41537.2 - 6.8 5.3 32.3 10 4.7 22.4 1.2 1 0 0 1 1 1 0 Paf1 MFS_1 PF07690.11 EDK41538.2 - 9.1e-29 100.2 19.1 1.3e-28 99.7 13.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Amidase PF01425.16 EDK41539.2 - 1.2e-94 317.7 0.0 1.5e-94 317.3 0.0 1.1 1 0 0 1 1 1 1 Amidase Peptidase_M16_C PF05193.16 EDK41540.2 - 5.6e-19 68.5 0.0 5.8e-15 55.4 0.0 2.9 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 EDK41540.2 - 1.7e-06 27.8 0.0 4.6e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) UFD1 PF03152.9 EDK41541.2 - 2.4e-18 65.9 0.4 7e-18 64.3 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin fusion degradation protein UFD1 Ribosomal_L31e PF01198.14 EDK41541.2 - 0.023 14.3 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L31e Peptidase_S8 PF00082.17 EDK41542.2 - 4.8e-52 176.8 9.1 7.6e-52 176.2 6.3 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EDK41542.2 - 3.3e-11 43.6 0.0 3.3e-11 43.6 0.0 2.2 3 0 0 3 3 3 1 Peptidase inhibitor I9 UQ_con PF00179.21 EDK41543.1 - 1.8e-48 163.5 0.1 2e-48 163.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK41543.1 - 1.7e-06 27.7 0.2 8e-06 25.6 0.0 1.8 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.17 EDK41543.1 - 0.021 14.6 0.2 0.049 13.5 0.2 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 EDK41543.1 - 0.085 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain COX4 PF02936.9 EDK41544.2 - 0.022 14.5 0.8 0.042 13.5 0.1 1.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV Peptidase_M41 PF01434.13 EDK41546.2 - 1.1e-74 250.4 0.0 2.1e-74 249.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 EDK41546.2 - 9.9e-43 145.4 1.6 6.7e-42 142.8 0.0 3.1 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 EDK41546.2 - 6.4e-05 23.7 0.1 0.00053 20.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain FtsH_ext PF06480.10 EDK41546.2 - 0.00086 19.4 0.5 0.00086 19.4 0.3 2.1 2 0 0 2 2 2 1 FtsH Extracellular AAA_22 PF13401.1 EDK41546.2 - 0.0011 19.1 3.1 0.17 12.0 0.3 4.2 3 2 1 4 4 3 1 AAA domain AAA_5 PF07728.9 EDK41546.2 - 0.0018 18.0 0.4 0.11 12.2 0.0 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 EDK41546.2 - 0.0028 16.4 0.0 0.0051 15.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 EDK41546.2 - 0.0072 15.4 0.1 0.03 13.3 0.0 2.1 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 EDK41546.2 - 0.0085 16.0 2.6 0.043 13.7 0.0 3.3 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 EDK41546.2 - 0.011 15.5 1.7 0.02 14.6 0.5 1.9 2 0 0 2 2 2 0 Part of AAA domain IstB_IS21 PF01695.12 EDK41546.2 - 0.026 13.9 0.0 0.061 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 EDK41546.2 - 0.062 12.3 0.7 0.29 10.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.1 EDK41546.2 - 0.094 12.6 0.1 0.37 10.7 0.1 2.0 2 1 0 2 2 1 0 AAA ATPase domain AAA_25 PF13481.1 EDK41546.2 - 0.11 11.8 0.9 0.58 9.5 0.2 2.3 1 1 1 2 2 2 0 AAA domain Fe-ADH_2 PF13685.1 EDK41546.2 - 0.33 10.2 0.9 1.3 8.2 0.0 2.3 3 0 0 3 3 3 0 Iron-containing alcohol dehydrogenase AAA_18 PF13238.1 EDK41546.2 - 0.38 11.0 0.0 0.38 11.0 0.0 2.9 4 0 0 4 4 3 0 AAA domain Exo_endo_phos PF03372.18 EDK41547.2 - 2e-10 41.0 1.1 2.6e-10 40.6 0.7 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 EDK41547.2 - 0.00015 21.3 0.1 0.00037 20.1 0.0 1.7 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Abhydrolase_6 PF12697.2 EDK41548.2 - 4.8e-09 36.4 0.0 1.1e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.10 EDK41548.2 - 5e-06 25.7 0.0 9.6e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.15 EDK41548.2 - 1.6e-05 24.5 0.0 2.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK41548.2 - 0.00035 20.3 0.0 0.00089 19.0 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 EDK41548.2 - 0.0086 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_8 PF06259.7 EDK41548.2 - 0.012 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase PGAP1 PF07819.8 EDK41548.2 - 0.025 14.1 0.0 0.071 12.6 0.0 1.7 1 0 0 1 1 1 0 PGAP1-like protein TcdB_N PF12918.2 EDK41548.2 - 0.036 14.1 0.5 0.098 12.7 0.3 1.7 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Ser_hydrolase PF06821.8 EDK41548.2 - 0.21 11.2 0.0 0.37 10.3 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase DnaJ PF00226.26 EDK41549.2 - 4.5e-18 64.7 0.1 7e-18 64.1 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.8 EDK41549.2 - 1.3e-16 59.8 0.3 2.2e-16 59.0 0.2 1.4 1 0 0 1 1 1 1 CSL zinc finger MOSC PF03473.12 EDK41549.2 - 0.011 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 MOSC domain RNA_pol_I_A49 PF06870.7 EDK41550.2 - 3.3e-137 457.1 1.4 3.7e-137 457.0 0.9 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor ATP-cone PF03477.11 EDK41550.2 - 0.027 14.8 2.3 0.062 13.7 1.6 1.6 1 0 0 1 1 1 0 ATP cone domain NAP PF00956.13 EDK41551.2 - 1.7e-32 112.4 5.9 2.1e-32 112.1 4.1 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) FAD_binding_3 PF01494.14 EDK41552.2 - 6e-19 68.3 0.0 2.2e-14 53.2 0.0 2.8 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 EDK41552.2 - 0.00017 20.6 0.1 0.011 14.6 0.1 2.7 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.19 EDK41552.2 - 0.00083 18.3 0.2 0.0015 17.5 0.1 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 EDK41552.2 - 0.0023 16.8 0.0 0.0033 16.3 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.9 EDK41552.2 - 0.0034 17.2 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 EDK41552.2 - 0.0041 15.8 0.0 0.31 9.5 0.0 2.2 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.1 EDK41552.2 - 0.0078 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 EDK41552.2 - 0.023 13.5 0.2 0.041 12.7 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.1 EDK41552.2 - 0.085 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 EDK41552.2 - 0.12 10.8 0.1 0.17 10.2 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Hpt PF01627.18 EDK41552.2 - 0.12 12.4 0.2 0.4 10.7 0.0 1.9 3 0 0 3 3 2 0 Hpt domain DUF676 PF05057.9 EDK41553.2 - 7.8e-08 31.8 0.0 4.4e-07 29.4 0.1 2.1 2 1 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 EDK41553.2 - 3.2e-07 30.1 0.0 6.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.6 EDK41553.2 - 1.7e-06 27.3 0.0 0.0094 15.0 0.0 2.8 3 0 0 3 3 3 2 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.10 EDK41553.2 - 0.0022 17.0 0.1 0.004 16.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.15 EDK41553.2 - 0.029 13.9 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.7 EDK41553.2 - 0.091 12.0 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_5 PF12695.2 EDK41553.2 - 0.12 12.1 0.0 1.1 8.9 0.0 2.2 2 1 0 2 2 2 0 Alpha/beta hydrolase family Aldedh PF00171.17 EDK41554.2 - 2.1e-113 379.1 1.1 2.5e-113 378.8 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PH PF00169.24 EDK41555.2 - 5e-09 36.2 0.2 2.3e-08 34.1 0.0 2.3 2 0 0 2 2 2 1 PH domain HLH PF00010.21 EDK41556.2 - 7.2e-16 57.6 0.2 1.6e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MIF4G_like PF09088.6 EDK41556.2 - 0.0039 16.6 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 MIF4G like LMBR1 PF04791.11 EDK41557.2 - 6.8e-20 71.0 30.0 2.7e-19 69.1 20.8 1.8 1 1 0 1 1 1 1 LMBR1-like membrane protein ADH_N PF08240.7 EDK41558.2 - 3.1e-08 33.3 0.0 5.3e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2722 PF10846.3 EDK41559.2 - 1.2e-104 350.6 19.2 1.2e-104 350.6 13.3 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF2722) SHQ1 PF04925.10 EDK41560.2 - 1.6e-76 255.9 0.1 2.6e-76 255.2 0.1 1.2 1 0 0 1 1 1 1 SHQ1 protein DUF4263 PF14082.1 EDK41560.2 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) Diphthamide_syn PF01866.12 EDK41561.2 - 5.5e-119 396.9 0.0 6.5e-119 396.7 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Arginase PF00491.16 EDK41562.2 - 4.8e-83 278.6 0.0 5.7e-83 278.4 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 EDK41562.2 - 0.015 15.5 0.3 0.031 14.4 0.2 1.6 1 0 0 1 1 1 0 UPF0489 domain Na_H_Exchanger PF00999.16 EDK41563.2 - 1.2e-34 119.5 31.5 1e-23 83.5 14.0 2.0 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family Rab_eff_C PF04698.7 EDK41563.2 - 0.085 10.9 3.9 0.12 10.5 2.7 1.0 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus S1FA PF04689.8 EDK41563.2 - 4.3 7.2 5.0 2 8.3 1.3 2.1 2 0 0 2 2 2 0 DNA binding protein S1FA Beta_helix PF13229.1 EDK41564.2 - 0.0051 16.5 4.0 0.33 10.7 0.2 3.2 1 1 0 3 3 3 2 Right handed beta helix region HELP PF03451.9 EDK41564.2 - 0.01 15.3 0.1 22 4.6 0.0 3.9 2 1 2 4 4 4 0 HELP motif DUF3068 PF11271.3 EDK41566.1 - 3.5 6.6 13.8 0.28 10.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3068) Sugar_tr PF00083.19 EDK41567.2 - 3.1e-78 263.3 33.5 3.6e-78 263.1 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41567.2 - 4.8e-32 111.0 33.0 1.5e-26 92.9 12.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.13 EDK41568.2 - 2.2e-06 26.7 2.2 4.1e-06 25.8 1.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain bZIP_2 PF07716.10 EDK41568.2 - 0.0069 16.1 0.7 0.015 15.1 0.5 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 EDK41568.2 - 0.0077 16.1 0.5 0.021 14.7 0.3 1.7 1 0 0 1 1 1 1 bZIP transcription factor Kinetocho_Slk19 PF12709.2 EDK41568.2 - 0.017 15.1 0.6 0.048 13.7 0.4 1.6 1 0 0 1 1 1 0 Central kinetochore-associated Zn_clus PF00172.13 EDK41568.2 - 0.041 13.7 15.3 0.084 12.7 10.6 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HALZ PF02183.13 EDK41568.2 - 0.066 12.9 1.8 0.18 11.5 1.3 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper Alpha-amylase PF00128.19 EDK41569.2 - 2e-99 332.9 0.6 3e-99 332.3 0.4 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 EDK41569.2 - 0.00022 20.2 0.1 0.0004 19.4 0.1 1.3 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme Asp PF00026.18 EDK41570.2 - 4.1e-60 203.6 9.2 5e-60 203.4 6.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 EDK41570.2 - 0.00024 21.0 0.0 0.0013 18.6 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal adh_short PF00106.20 EDK41571.2 - 4.5e-13 49.4 0.0 4.5e-13 49.4 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 EDK41571.2 - 1.7e-07 31.1 0.0 2.4e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 EDK41571.2 - 1.1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 EDK41571.2 - 4.6e-05 23.5 0.1 0.00011 22.2 0.1 1.6 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 EDK41571.2 - 0.0092 15.4 0.0 0.011 15.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.1 EDK41571.2 - 0.017 15.3 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.14 EDK41571.2 - 0.029 13.4 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain p450 PF00067.17 EDK41572.2 - 2.7e-62 210.8 0.0 3.5e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_4 PF12799.2 EDK41573.2 - 7.9e-05 22.1 18.1 0.0072 15.9 0.0 6.8 5 3 1 6 6 6 1 Leucine Rich repeats (2 copies) LysM PF01476.15 EDK41573.2 - 0.015 15.1 0.0 0.046 13.6 0.0 1.8 1 0 0 1 1 1 0 LysM domain LRR_7 PF13504.1 EDK41573.2 - 0.13 12.5 15.3 56 4.6 0.1 8.3 8 1 1 9 9 9 0 Leucine rich repeat LRR_8 PF13855.1 EDK41573.2 - 0.17 11.6 13.4 1.1 9.1 0.2 6.0 4 3 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 EDK41573.2 - 2.9 8.2 17.4 12 6.3 1.5 7.0 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.2 EDK41574.2 - 7.3e-10 38.2 10.0 0.044 13.4 0.0 5.5 4 2 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK41574.2 - 1.7e-08 33.3 7.7 5.5 7.4 0.0 6.8 7 0 0 7 7 7 4 Leucine Rich Repeat LRR_7 PF13504.1 EDK41574.2 - 3.6e-07 29.3 11.3 4.2 8.0 0.0 7.4 8 0 0 8 8 8 3 Leucine rich repeat LRR_8 PF13855.1 EDK41574.2 - 8.6e-07 28.6 9.8 0.0085 15.8 0.3 4.5 1 1 4 5 5 5 5 Leucine rich repeat FNIP PF05725.7 EDK41574.2 - 0.0029 17.5 6.6 0.2 11.6 0.0 4.5 4 2 1 5 5 5 2 FNIP Repeat LRR_3 PF07725.7 EDK41574.2 - 0.12 12.2 4.5 1.7 8.5 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.1 EDK41574.2 - 0.21 11.7 11.1 42 4.6 0.0 6.2 6 1 1 7 7 7 0 Leucine Rich repeat LRR_4 PF12799.2 EDK41575.2 - 9.1e-11 41.1 34.1 0.012 15.2 0.5 10.5 5 3 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK41575.2 - 1.5e-06 27.8 26.3 0.03 14.0 0.4 8.4 7 2 2 9 9 9 3 Leucine rich repeat LRR_1 PF00560.28 EDK41575.2 - 7.6e-05 22.2 29.7 1.9 8.8 0.0 11.8 9 3 2 11 11 11 2 Leucine Rich Repeat FNIP PF05725.7 EDK41575.2 - 0.00014 21.7 17.5 0.17 11.8 0.2 7.3 5 3 0 6 6 6 2 FNIP Repeat LRR_7 PF13504.1 EDK41575.2 - 0.12 12.6 33.7 21 5.9 0.0 12.6 14 2 1 15 15 15 0 Leucine rich repeat LRR_4 PF12799.2 EDK41577.2 - 3.7e-08 32.7 30.4 0.12 12.0 0.3 9.1 3 1 9 12 12 12 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK41577.2 - 3e-06 26.4 30.1 0.97 9.7 0.0 10.5 8 5 2 10 10 10 4 Leucine Rich Repeat LRR_8 PF13855.1 EDK41577.2 - 2.1e-05 24.1 33.4 0.0002 21.0 1.0 7.8 3 2 7 11 11 11 5 Leucine rich repeat LRR_7 PF13504.1 EDK41577.2 - 0.0014 18.4 28.8 4.9 7.8 0.1 11.1 13 0 0 13 13 13 2 Leucine rich repeat FNIP PF05725.7 EDK41577.2 - 0.0018 18.1 31.5 0.13 12.2 1.0 7.0 8 0 0 8 8 8 4 FNIP Repeat Pyr_redox_2 PF07992.9 EDK41578.2 - 9.6e-16 58.2 0.0 1.9e-15 57.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 EDK41578.2 - 5.8e-10 39.4 0.1 3.4e-06 27.3 0.0 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 EDK41578.2 - 3e-07 30.7 2.0 2.2e-05 24.6 0.0 3.0 1 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 EDK41578.2 - 1.3e-05 24.2 0.1 8e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 EDK41578.2 - 1.5e-05 23.8 2.9 0.035 12.7 0.1 3.3 4 0 0 4 4 4 2 Tryptophan halogenase NAD_binding_9 PF13454.1 EDK41578.2 - 0.0003 20.5 2.0 1.3 8.7 0.0 4.2 3 1 0 4 4 4 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.1 EDK41578.2 - 0.0016 18.6 0.4 0.2 11.9 0.0 2.7 1 1 1 2 2 2 1 Putative NAD(P)-binding Lipase PF00151.14 EDK41578.2 - 0.0017 17.6 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Lipase Fer4_14 PF13394.1 EDK41578.2 - 0.0092 15.9 0.2 0.052 13.5 0.1 2.3 1 1 1 2 2 2 1 4Fe-4S single cluster domain GIDA PF01134.17 EDK41578.2 - 1.5 7.6 6.4 0.2 10.4 0.6 2.3 1 1 2 3 3 3 0 Glucose inhibited division protein A Ammonium_transp PF00909.16 EDK41580.1 - 1.9e-88 296.6 21.9 2.2e-88 296.4 15.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Reticulon PF02453.12 EDK41580.1 - 0.021 14.4 9.2 1.5 8.4 0.0 3.3 3 0 0 3 3 3 0 Reticulon Fungal_trans_2 PF11951.3 EDK41582.2 - 3.2e-38 131.3 5.3 3.9e-38 131.0 3.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 EDK41582.2 - 5.1e-08 32.6 7.6 9e-08 31.9 5.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.9 EDK41583.2 - 1e-91 307.8 3.2 1.2e-91 307.5 2.2 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_B PF02538.9 EDK41584.1 - 6.2e-59 199.6 0.1 7.6e-59 199.3 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Pox_P4B PF03292.9 EDK41584.1 - 0.064 11.1 0.1 0.17 9.8 0.0 1.6 2 0 0 2 2 2 0 Poxvirus P4B major core protein Hydantoinase_A PF01968.13 EDK41586.1 - 6.3e-75 251.9 0.1 1.6e-73 247.3 0.0 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EDK41586.1 - 1.2e-55 187.6 3.4 1.6e-54 184.0 0.1 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Radical_SAM PF04055.16 EDK41586.1 - 0.019 15.1 0.4 0.17 12.0 0.1 2.5 2 1 0 2 2 2 0 Radical SAM superfamily MutL PF13941.1 EDK41586.1 - 0.056 11.7 0.2 0.37 9.0 0.0 2.0 2 0 0 2 2 2 0 MutL protein DAO PF01266.19 EDK41587.2 - 1.3e-22 80.2 0.1 2e-22 79.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK41587.2 - 2.1e-05 23.5 0.2 4.8e-05 22.3 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 EDK41587.2 - 3.9e-05 22.8 0.0 5.9e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 EDK41587.2 - 0.0005 19.8 0.2 0.84 9.3 0.2 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding 3HCDH_N PF02737.13 EDK41587.2 - 0.00053 19.6 0.4 0.0012 18.5 0.2 1.5 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.1 EDK41587.2 - 0.00065 19.6 0.0 0.0019 18.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 EDK41587.2 - 0.00081 19.3 0.6 0.014 15.3 0.4 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 EDK41587.2 - 0.0014 17.7 0.1 0.0031 16.6 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 EDK41587.2 - 0.0032 17.5 0.0 0.38 10.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 EDK41587.2 - 0.0036 16.4 0.0 0.24 10.5 0.0 2.8 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 EDK41587.2 - 0.0078 16.5 0.0 0.03 14.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK41587.2 - 0.0083 15.5 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.16 EDK41587.2 - 0.029 13.9 0.1 0.073 12.6 0.1 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 EDK41587.2 - 0.036 13.9 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TPMT PF05724.6 EDK41587.2 - 0.057 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) ApbA PF02558.11 EDK41587.2 - 0.11 11.8 0.1 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MFS_1 PF07690.11 EDK41588.2 - 1.7e-33 115.8 28.1 2.2e-33 115.4 19.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 EDK41588.2 - 0.00017 21.5 4.6 0.00062 19.7 0.6 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1228) FAD_binding_6 PF00970.19 EDK41589.2 - 2.7e-14 53.0 0.0 3.5e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain MFS_1 PF07690.11 EDK41590.1 - 0.00025 19.8 14.2 0.00043 19.1 9.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Globin PF00042.17 EDK41591.2 - 2.3e-10 40.7 0.0 6.8e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Globin Protoglobin PF11563.3 EDK41591.2 - 0.012 15.2 0.0 0.02 14.5 0.0 1.4 1 1 0 1 1 1 0 Protoglobin Bac_globin PF01152.16 EDK41591.2 - 0.057 13.4 0.1 0.35 10.8 0.0 2.2 1 1 0 1 1 1 0 Bacterial-like globin FAD_binding_6 PF00970.19 EDK41591.2 - 0.065 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Epimerase PF01370.16 EDK41592.1 - 1.5e-05 24.5 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family FAD_binding_6 PF00970.19 EDK41593.2 - 2.1e-14 53.4 0.0 3.8e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 EDK41593.2 - 1.6e-09 38.2 0.0 1.9e-08 34.8 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF3221 PF11518.3 EDK41593.2 - 0.021 14.5 0.1 3.3 7.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3221) NAD_binding_6 PF08030.7 EDK41593.2 - 0.058 13.3 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Epimerase PF01370.16 EDK41594.1 - 0.0088 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2145 PF09916.4 EDK41596.2 - 0.026 14.0 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2145) PTase_Orf2 PF11468.3 EDK41598.2 - 0.039 13.1 0.0 0.051 12.7 0.0 1.1 1 0 0 1 1 1 0 Aromatic prenyltransferase Orf2 UQ_con PF00179.21 EDK41599.1 - 9.4e-46 154.7 0.0 1.1e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK41599.1 - 7.4e-05 22.5 0.0 9.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 EDK41599.1 - 0.037 13.9 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.8 EDK41599.1 - 0.043 13.5 0.0 0.084 12.5 0.0 1.5 1 1 0 1 1 1 0 UEV domain E1-E2_ATPase PF00122.15 EDK41600.2 - 9.7e-17 60.7 1.6 1.4e-15 56.9 0.0 2.7 3 0 0 3 3 3 1 E1-E2 ATPase HAD PF12710.2 EDK41600.2 - 9.9e-14 51.9 0.4 1.1e-12 48.4 0.3 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 EDK41600.2 - 6.2e-13 48.5 0.0 1.7e-12 47.1 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 EDK41600.2 - 1.6e-11 45.0 0.2 1e-06 29.2 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK41600.2 - 0.0032 17.1 0.1 0.0091 15.6 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mito_carr PF00153.22 EDK41601.1 - 2.8e-69 228.8 4.5 5.2e-24 83.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SAM_decarbox PF01536.11 EDK41603.2 - 3.2e-96 321.8 5.4 5e-95 317.9 3.8 2.0 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase Dynamin_M PF01031.15 EDK41604.2 - 6.4e-104 346.8 0.1 1.1e-103 346.1 0.1 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 EDK41604.2 - 7.6e-56 188.5 0.1 1.3e-55 187.7 0.1 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 EDK41604.2 - 5.7e-25 87.0 5.1 5.7e-25 87.0 3.5 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 EDK41604.2 - 0.00089 19.2 2.3 0.011 15.7 0.3 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 EDK41604.2 - 0.044 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Pkinase PF00069.20 EDK41605.2 - 7.6e-72 241.5 0.0 1e-71 241.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41605.2 - 1.6e-42 145.3 0.0 2e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK41605.2 - 4.2e-09 35.7 0.0 4.3e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 EDK41605.2 - 0.046 13.4 0.1 0.61 9.7 0.1 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_C PF00433.19 EDK41605.2 - 0.068 13.7 0.0 0.24 11.9 0.0 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain Macro PF01661.16 EDK41606.2 - 9.3e-24 83.6 0.0 1.2e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Macro domain WD40 PF00400.27 EDK41607.2 - 3.9e-05 23.3 5.3 0.01 15.7 0.3 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat CENP-F_leu_zip PF10473.4 EDK41608.2 - 0.00016 21.5 3.8 0.00016 21.5 2.6 4.2 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.1 EDK41608.2 - 0.0012 18.0 22.0 0.0012 18.0 15.2 2.4 1 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF869 PF05911.6 EDK41608.2 - 0.0084 14.4 30.5 0.063 11.5 16.0 2.1 1 1 1 2 2 2 2 Plant protein of unknown function (DUF869) WGG PF10273.4 EDK41608.2 - 0.011 15.7 0.5 0.035 14.1 0.1 2.0 2 0 0 2 2 1 0 Pre-rRNA-processing protein TSR2 HALZ PF02183.13 EDK41608.2 - 0.037 13.7 10.6 0.52 10.0 1.5 4.3 3 1 1 4 4 4 0 Homeobox associated leucine zipper DivIC PF04977.10 EDK41608.2 - 0.043 13.3 13.1 0.4 10.2 0.4 3.5 1 1 1 3 3 3 0 Septum formation initiator Tup_N PF08581.5 EDK41608.2 - 0.11 12.6 10.8 1.3 9.3 1.9 3.4 2 1 1 3 3 2 0 Tup N-terminal PilJ PF13675.1 EDK41608.2 - 0.14 12.4 6.6 1.2 9.4 0.2 3.5 1 1 3 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pox_A_type_inc PF04508.7 EDK41608.2 - 0.14 11.9 2.0 19 5.3 0.7 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat CCDC155 PF14662.1 EDK41608.2 - 0.17 11.4 23.0 0.015 14.8 6.4 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 Serine_rich PF08824.5 EDK41608.2 - 0.23 11.1 8.3 0.21 11.2 0.4 2.7 1 1 1 2 2 2 0 Serine rich protein interaction domain Phage_lysis PF03245.8 EDK41608.2 - 0.36 10.8 7.6 0.066 13.2 1.3 2.5 1 1 0 2 2 2 0 Bacteriophage Rz lysis protein FlaC_arch PF05377.6 EDK41608.2 - 0.42 10.5 8.6 3.1 7.7 0.3 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MCC-bdg_PDZ PF10506.4 EDK41608.2 - 0.47 10.3 6.8 7.6 6.4 0.0 3.7 2 1 2 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome IncA PF04156.9 EDK41608.2 - 1.7 8.2 26.7 2.6 7.6 11.2 3.6 1 1 1 2 2 2 0 IncA protein NusB PF01029.13 EDK41608.2 - 2 8.3 10.1 0.37 10.7 0.8 2.7 2 0 0 2 2 2 0 NusB family DUF3086 PF11285.3 EDK41608.2 - 2.1 7.0 10.5 12 4.5 4.9 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3086) DUF3450 PF11932.3 EDK41608.2 - 2.2 7.4 18.1 3 7.0 0.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF4140 PF13600.1 EDK41608.2 - 2.5 8.6 7.1 11 6.5 0.0 3.7 3 1 0 4 4 3 0 N-terminal domain of unknown function (DUF4140) FliD_N PF02465.13 EDK41608.2 - 2.6 8.4 22.6 0.11 12.8 2.6 4.5 2 1 2 4 4 4 0 Flagellar hook-associated protein 2 N-terminus Reo_sigmaC PF04582.7 EDK41608.2 - 3 6.9 17.3 0.25 10.4 0.8 3.1 1 1 1 3 3 3 0 Reovirus sigma C capsid protein ERM PF00769.14 EDK41608.2 - 3.1 7.2 25.4 0.025 14.0 6.3 3.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Osmo_CC PF08946.5 EDK41608.2 - 4 7.5 7.2 35 4.5 0.4 4.3 4 0 0 4 4 4 0 Osmosensory transporter coiled coil Pup PF05639.6 EDK41608.2 - 5.8 7.4 8.1 6.2 7.4 0.1 4.0 3 1 1 4 4 3 0 Pup-like protein CENP-F_N PF10481.4 EDK41608.2 - 7.5 5.8 26.6 0.015 14.7 8.9 2.8 1 1 1 3 3 3 0 Cenp-F N-terminal domain bZIP_1 PF00170.16 EDK41608.2 - 9.4 6.2 28.3 0.086 12.8 2.9 5.1 5 2 1 6 6 5 0 bZIP transcription factor DUF3074 PF11274.3 EDK41609.1 - 3.9e-40 137.4 0.1 6.1e-40 136.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) AAA PF00004.24 EDK41611.2 - 2.5e-10 40.6 0.0 5.3e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 EDK41611.2 - 7.2e-08 32.6 0.0 2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 EDK41611.2 - 6.7e-07 28.3 2.1 1.8e-06 26.9 1.4 1.7 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_5 PF07728.9 EDK41611.2 - 1.3e-06 28.1 0.0 3.3e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 EDK41611.2 - 5.4e-06 26.3 0.0 1.9e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 EDK41611.2 - 0.00041 19.4 0.0 0.00078 18.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 EDK41611.2 - 0.0014 18.6 0.0 0.042 13.8 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 EDK41611.2 - 0.0078 15.9 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 EDK41611.2 - 0.021 14.9 0.0 0.12 12.5 0.0 2.4 1 1 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 EDK41611.2 - 0.029 13.4 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 EDK41611.2 - 0.03 14.6 0.8 0.26 11.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.21 EDK41611.2 - 0.039 13.4 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.1 EDK41611.2 - 0.068 13.9 0.0 0.17 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 EDK41611.2 - 0.083 11.9 0.1 0.41 9.7 0.0 2.0 1 1 1 2 2 2 0 KaiC AAA_11 PF13086.1 EDK41611.2 - 0.089 12.3 0.1 0.089 12.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 EDK41611.2 - 0.099 12.3 0.0 0.26 10.9 0.0 1.8 1 1 0 1 1 1 0 NACHT domain AAA_3 PF07726.6 EDK41611.2 - 0.12 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CRAL_TRIO PF00650.15 EDK41612.1 - 5.7e-37 126.6 0.0 8.7e-37 126.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 EDK41612.1 - 2.7e-11 43.4 0.5 6.8e-11 42.1 0.1 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 EDK41612.1 - 0.0012 18.7 0.0 0.0064 16.4 0.0 1.9 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain RasGAP PF00616.14 EDK41613.2 - 1.6e-63 213.9 0.3 1.6e-63 213.9 0.2 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 EDK41613.2 - 0.00042 20.0 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 1 C2 domain UPF1_Zn_bind PF09416.5 EDK41614.2 - 8.1e-68 226.8 8.7 8.1e-68 226.8 6.1 2.5 2 1 1 3 3 3 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 EDK41614.2 - 2.6e-59 199.9 0.0 6e-59 198.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 EDK41614.2 - 1.1e-52 178.9 3.5 1.9e-52 178.1 2.4 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 EDK41614.2 - 6.7e-14 51.9 0.6 8.2e-13 48.3 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 EDK41614.2 - 4.2e-13 48.8 0.0 1.7e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 EDK41614.2 - 2.2e-06 27.6 0.2 4.2e-06 26.7 0.2 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 EDK41614.2 - 0.00025 20.5 0.2 0.00044 19.7 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.13 EDK41614.2 - 0.0012 18.3 4.8 0.93 8.9 0.0 3.6 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 EDK41614.2 - 0.0013 18.0 4.0 0.18 11.0 2.5 2.4 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.4 EDK41614.2 - 0.0023 16.9 7.5 0.0033 16.4 0.2 3.9 4 1 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 EDK41614.2 - 0.0074 15.5 0.0 0.019 14.2 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein UvrD_C_2 PF13538.1 EDK41614.2 - 0.016 15.3 0.2 0.092 12.8 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 EDK41614.2 - 0.025 14.7 0.0 0.068 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.9 EDK41614.2 - 0.031 13.2 0.0 3 6.7 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase Ribosomal_S13_N PF08069.7 EDK41614.2 - 0.12 12.2 0.0 0.36 10.6 0.0 1.8 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain AAA_25 PF13481.1 EDK41614.2 - 0.14 11.5 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RE_HindIII PF09518.5 EDK41615.2 - 0.0088 14.9 2.3 0.0088 14.9 1.6 2.1 2 0 0 2 2 2 1 HindIII restriction endonuclease FlgN PF05130.7 EDK41615.2 - 0.65 10.2 12.7 0.12 12.6 5.5 2.0 2 0 0 2 2 2 0 FlgN protein TMPIT PF07851.8 EDK41615.2 - 5.6 5.9 17.5 0.27 10.2 1.8 2.8 2 1 1 3 3 3 0 TMPIT-like protein Epimerase PF01370.16 EDK41616.2 - 8.5e-18 64.6 0.0 1.3e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK41616.2 - 1.2e-15 56.9 0.0 1.8e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK41616.2 - 4.4e-13 49.6 0.2 7.7e-13 48.8 0.1 1.4 1 1 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK41616.2 - 4.4e-10 38.8 0.0 1.3e-09 37.3 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EDK41616.2 - 0.0019 18.1 0.2 0.0042 17.0 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.8 EDK41616.2 - 0.0033 16.7 0.0 0.023 13.9 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family F420_oxidored PF03807.12 EDK41616.2 - 0.047 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Abhydrolase_6 PF12697.2 EDK41617.2 - 2.2e-29 102.9 0.1 2.7e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41617.2 - 1.1e-15 57.7 0.0 1.4e-14 54.1 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK41617.2 - 2.9e-10 40.0 0.0 4.8e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 EDK41617.2 - 0.044 13.0 0.0 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family TRAUB PF08164.7 EDK41618.2 - 1.4e-28 98.8 1.7 4e-28 97.3 0.0 2.8 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.1 EDK41618.2 - 2.4e-26 92.4 4.8 2.4e-26 92.4 3.3 3.2 3 1 1 4 4 4 1 Apoptosis antagonizing transcription factor Daxx PF03344.10 EDK41618.2 - 0.049 12.1 34.6 0.086 11.3 24.0 1.5 1 0 0 1 1 1 0 Daxx Family DUF2457 PF10446.4 EDK41618.2 - 0.25 10.0 28.3 0.01 14.5 15.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) IF4E PF01652.13 EDK41620.1 - 9.5e-60 200.8 1.1 1.2e-59 200.6 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Abhydrolase_5 PF12695.2 EDK41621.2 - 4.3e-18 65.4 0.0 6.2e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK41621.2 - 6.7e-13 49.0 0.0 2.5e-11 43.9 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41621.2 - 2.8e-09 36.8 0.7 7.2e-07 28.9 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold BAAT_C PF08840.6 EDK41621.2 - 6.4e-05 22.7 0.0 0.0037 16.9 0.0 2.4 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF818 PF05677.7 EDK41621.2 - 7.3e-05 21.6 0.3 0.00011 21.0 0.2 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.16 EDK41621.2 - 0.00078 18.7 0.0 0.0057 15.9 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 EDK41621.2 - 0.0021 17.5 0.1 0.038 13.4 0.1 2.1 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 EDK41621.2 - 0.0026 17.5 0.0 0.0091 15.8 0.0 2.0 2 0 0 2 2 2 1 Putative lysophospholipase Lipase_3 PF01764.20 EDK41621.2 - 0.0053 16.3 0.0 0.0087 15.6 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.7 EDK41621.2 - 0.033 12.6 0.1 0.15 10.5 0.0 1.9 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) UPF0227 PF05728.7 EDK41621.2 - 0.05 13.3 0.3 0.22 11.2 0.2 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) Esterase PF00756.15 EDK41621.2 - 0.057 12.8 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DLH PF01738.13 EDK41621.2 - 0.11 11.7 0.0 0.8 8.9 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydro_lipase PF04083.11 EDK41621.2 - 0.11 11.8 0.1 0.27 10.5 0.1 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Abhydrolase_3 PF07859.8 EDK41621.2 - 0.13 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold WD40 PF00400.27 EDK41622.2 - 7.1e-15 54.2 5.1 7.1e-07 28.8 0.0 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-RING_2 PF13639.1 EDK41622.2 - 2.7e-05 23.9 5.7 2.7e-05 23.9 4.0 2.7 3 0 0 3 3 3 1 Ring finger domain Peripla_BP_6 PF13458.1 EDK41622.2 - 0.26 10.6 0.0 0.35 10.1 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein zf-rbx1 PF12678.2 EDK41622.2 - 1.9 8.6 11.5 6.6 6.9 8.0 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger Sld5 PF05916.6 EDK41623.2 - 1.6e-06 28.3 0.6 3.2e-06 27.3 0.3 1.6 1 1 0 1 1 1 1 GINS complex protein tRNA-synt_1e PF01406.14 EDK41623.2 - 0.05 12.7 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain WD40 PF00400.27 EDK41624.2 - 0.02 14.7 10.5 1.6 8.7 0.1 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat Pox_Ag35 PF03286.9 EDK41624.2 - 0.97 8.9 5.9 1.6 8.1 4.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rad21_Rec8_N PF04825.8 EDK41625.2 - 7.6e-29 99.8 0.5 1.5e-28 98.9 0.1 1.7 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 EDK41625.2 - 3.1e-07 29.4 0.0 8.1e-07 28.1 0.0 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Med2 PF11214.3 EDK41626.2 - 8.1e-36 122.2 3.4 8.1e-36 122.2 2.4 2.2 1 1 1 2 2 1 1 Mediator complex subunit 2 U79_P34 PF03064.11 EDK41626.2 - 0.00039 20.0 5.9 0.0006 19.4 4.1 1.4 1 0 0 1 1 1 1 HSV U79 / HCMV P34 MIP-T3 PF10243.4 EDK41626.2 - 0.0066 14.9 13.3 0.0079 14.7 9.2 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 DUF4246 PF14033.1 EDK41626.2 - 0.017 13.7 4.1 0.019 13.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) FLO_LFY PF01698.11 EDK41626.2 - 0.026 13.3 5.8 0.033 13.0 4.0 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 EDK41626.2 - 0.08 12.8 4.0 0.086 12.7 2.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RAP1 PF07218.6 EDK41626.2 - 0.26 9.3 5.4 0.31 9.0 3.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Vfa1 PF08432.5 EDK41626.2 - 0.34 10.9 15.1 0.59 10.1 10.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ycf1 PF05758.7 EDK41626.2 - 0.41 8.2 6.1 0.42 8.2 4.2 1.1 1 0 0 1 1 1 0 Ycf1 RR_TM4-6 PF06459.7 EDK41626.2 - 0.75 9.6 8.0 1.2 8.9 5.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SpoVR PF04293.8 EDK41626.2 - 0.81 7.9 5.7 1 7.6 3.9 1.1 1 0 0 1 1 1 0 SpoVR like protein CAF-1_p150 PF11600.3 EDK41626.2 - 1.4 8.2 27.8 2.1 7.6 19.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Atrophin-1 PF03154.10 EDK41626.2 - 1.5 6.8 14.2 1.9 6.5 9.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family CDC45 PF02724.9 EDK41626.2 - 1.7 6.5 11.2 2 6.3 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP_sp32 PF07222.7 EDK41626.2 - 2.4 7.2 9.4 3.5 6.7 6.5 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 NARP1 PF12569.3 EDK41626.2 - 3.2 6.4 12.4 4.4 5.9 8.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GvpL_GvpF PF06386.6 EDK41626.2 - 4.9 6.6 11.9 7.7 6.0 8.3 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DDHD PF02862.12 EDK41626.2 - 5 6.8 8.7 7.1 6.3 6.0 1.2 1 0 0 1 1 1 0 DDHD domain ATP-synt_DE_N PF02823.11 EDK41627.2 - 8.2e-23 79.9 0.0 1.5e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ADH_zinc_N PF00107.21 EDK41628.2 - 1e-25 89.7 0.2 1.8e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 EDK41628.2 - 4.3e-25 87.5 0.6 8.6e-25 86.6 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Pyr_redox PF00070.22 EDK41628.2 - 0.0046 17.3 1.1 0.16 12.3 1.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 EDK41628.2 - 0.018 13.5 0.5 0.027 12.9 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein ADH_zinc_N_2 PF13602.1 EDK41628.2 - 0.06 14.2 0.1 0.61 10.9 0.0 2.4 1 1 1 2 2 2 0 Zinc-binding dehydrogenase NAD_binding_3 PF03447.11 EDK41628.2 - 0.082 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 EDK41628.2 - 0.1 12.8 0.1 0.33 11.2 0.3 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.9 EDK41628.2 - 0.12 10.9 0.6 0.19 10.3 0.4 1.2 1 0 0 1 1 1 0 Tryptophan halogenase AlaDh_PNT_C PF01262.16 EDK41628.2 - 0.13 11.8 1.6 0.25 10.8 1.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.19 EDK41628.2 - 0.2 10.4 1.7 0.28 9.9 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 EDK41628.2 - 0.25 10.1 1.2 0.34 9.7 0.8 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 EDK41628.2 - 0.55 9.2 4.7 0.9 8.5 3.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase LSM PF01423.17 EDK41630.1 - 2.5e-13 49.3 0.0 3.9e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 EDK41630.1 - 2.8e-06 27.1 0.0 3.9e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DER1 PF04511.10 EDK41631.2 - 4.6e-21 75.2 14.3 1.9e-20 73.2 6.1 2.1 1 1 1 2 2 2 2 Der1-like family DUF2919 PF11143.3 EDK41631.2 - 0.82 9.4 5.6 15 5.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) Na_Ca_ex PF01699.19 EDK41632.2 - 2.6e-28 98.3 25.0 8.6e-16 57.8 3.1 4.2 4 1 1 5 5 5 2 Sodium/calcium exchanger protein DUF307 PF03733.8 EDK41632.2 - 6.2e-14 52.1 6.6 6.2e-14 52.1 4.6 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF307) DUF1049 PF06305.6 EDK41632.2 - 0.64 9.5 9.5 3.2 7.3 2.5 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) Alpha-amylase PF00128.19 EDK41633.1 - 7.7e-104 347.4 1.2 7.7e-104 347.4 0.8 1.7 3 0 0 3 3 3 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.1 EDK41633.1 - 0.0018 17.2 0.0 0.006 15.5 0.0 1.8 2 0 0 2 2 2 1 glucanotransferase domain of human glycogen debranching enzyme Zn_clus PF00172.13 EDK41634.2 - 6.6e-07 29.1 11.7 1.3e-06 28.2 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lipase_GDSL_2 PF13472.1 EDK41635.2 - 7e-10 39.3 0.0 8.6e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 EDK41635.2 - 7.4e-08 32.4 0.0 9e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3196 PF11428.3 EDK41635.2 - 0.025 13.8 0.0 0.052 12.8 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3196) Ribosomal_S3_C PF00189.15 EDK41635.2 - 0.12 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain PAH PF02671.16 EDK41638.2 - 1.2e-39 133.6 1.7 1.4e-19 69.4 0.4 2.3 2 0 0 2 2 2 2 Paired amphipathic helix repeat Sin3_corepress PF08295.7 EDK41639.2 - 2.2e-43 146.0 0.1 7.6e-43 144.3 0.0 2.0 1 0 0 1 1 1 1 Sin3 family co-repressor Membr_traf_MHD PF10540.4 EDK41640.2 - 1.8e-14 53.7 0.0 2.9e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain DUF4650 PF15509.1 EDK41640.2 - 0.052 12.4 1.0 0.078 11.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) C2 PF00168.25 EDK41641.2 - 1.6e-08 34.2 0.0 4e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain SWIB PF02201.13 EDK41642.2 - 1.2e-21 76.1 0.2 2.8e-21 74.9 0.2 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.6 EDK41642.2 - 1.4e-11 43.9 1.3 2.2e-11 43.3 0.3 1.8 2 0 0 2 2 2 1 DEK C terminal domain RRS1 PF04939.7 EDK41643.1 - 2.8e-67 225.3 7.5 3.2e-67 225.0 5.2 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Miro PF08477.8 EDK41644.2 - 5.9e-33 113.8 0.0 1.4e-15 57.8 0.0 2.9 2 1 0 2 2 2 2 Miro-like protein EF_assoc_1 PF08355.7 EDK41644.2 - 2.7e-31 106.6 1.2 4.9e-31 105.8 0.9 1.4 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.7 EDK41644.2 - 4.4e-28 96.8 0.0 1.1e-27 95.6 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Ras PF00071.17 EDK41644.2 - 1.6e-21 76.3 0.0 9.9e-10 38.0 0.0 3.2 3 0 0 3 3 3 3 Ras family EF-hand_1 PF00036.27 EDK41644.2 - 2.1e-08 32.8 2.9 0.0026 16.9 0.5 3.0 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.18 EDK41644.2 - 6.9e-08 32.4 0.0 0.0021 18.0 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.1 EDK41644.2 - 1.9e-07 31.1 0.3 0.011 15.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 EDK41644.2 - 4.6e-07 29.1 3.0 0.019 14.8 0.3 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 EDK41644.2 - 1.9e-05 23.7 5.3 0.02 14.2 2.2 2.8 2 0 0 2 2 2 2 EF hand Arf PF00025.16 EDK41644.2 - 6.4e-05 22.2 0.0 0.35 10.0 0.0 3.4 3 0 0 3 3 3 1 ADP-ribosylation factor family MobB PF03205.9 EDK41644.2 - 0.00015 21.5 0.0 0.7 9.5 0.0 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 EDK41644.2 - 0.0008 19.1 0.0 0.25 11.0 0.0 2.5 2 0 0 2 2 2 1 Archaeal ATPase GTP_EFTU PF00009.22 EDK41644.2 - 0.0015 17.9 0.0 0.31 10.4 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain EF-hand_8 PF13833.1 EDK41644.2 - 0.0049 16.4 1.0 0.17 11.5 0.2 2.7 2 0 0 2 2 2 1 EF-hand domain pair Dynamin_N PF00350.18 EDK41644.2 - 0.0084 15.9 0.0 1.2 8.8 0.0 2.4 2 0 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.13 EDK41644.2 - 0.026 14.0 0.0 0.28 10.6 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.1 EDK41644.2 - 0.029 14.3 0.0 0.63 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain NAD_binding_10 PF13460.1 EDK41644.2 - 0.038 14.0 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 NADH(P)-binding AAA_22 PF13401.1 EDK41644.2 - 0.042 13.9 0.0 16 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 EDK41644.2 - 0.053 12.7 0.0 9.7 5.4 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_32 PF13654.1 EDK41644.2 - 0.1 11.2 0.0 0.88 8.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain BolA PF01722.13 EDK41645.2 - 4.1e-16 58.7 0.0 4.8e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein eIF2A PF08662.6 EDK41646.2 - 5.5e-39 133.9 0.6 1.3e-34 119.6 1.0 3.7 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 EDK41646.2 - 8.6e-09 34.9 0.1 2e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 EDK41646.2 - 5e-07 29.4 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 EDK41646.2 - 1.7e-06 27.9 0.1 3.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 EDK41646.2 - 0.25 11.3 2.2 28 4.7 0.0 4.4 5 0 0 5 5 5 0 WD domain, G-beta repeat Mto2_bdg PF12808.2 EDK41647.2 - 1.7e-06 28.0 5.7 1.7e-06 28.0 4.0 7.0 7 0 0 7 7 7 1 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF4407 PF14362.1 EDK41647.2 - 0.0077 15.2 34.2 0.17 10.8 0.8 4.1 2 1 2 4 4 4 3 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.7 EDK41647.2 - 0.021 14.6 1.4 0.021 14.6 0.9 5.8 4 1 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.7 EDK41647.2 - 0.021 15.1 0.3 0.021 15.1 0.2 7.5 6 1 3 9 9 9 0 SlyX bZIP_1 PF00170.16 EDK41647.2 - 0.031 14.2 0.1 0.031 14.2 0.0 8.7 6 4 2 9 9 9 0 bZIP transcription factor TPR_MLP1_2 PF07926.7 EDK41647.2 - 0.21 11.3 0.0 0.21 11.3 0.0 7.2 3 2 2 5 5 5 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.3 EDK41647.2 - 3 5.0 50.2 15 2.7 33.7 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) APG6 PF04111.7 EDK41647.2 - 3.5 6.6 49.7 1.2 8.0 0.3 4.4 3 1 1 4 4 4 0 Autophagy protein Apg6 DivIC PF04977.10 EDK41647.2 - 9.2 5.8 47.0 0.17 11.3 0.4 7.2 6 1 1 7 7 7 0 Septum formation initiator Proteasome PF00227.21 EDK41648.1 - 2.2e-52 177.1 0.0 2.8e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 EDK41648.1 - 3.2e-13 48.7 0.8 4.3e-13 48.3 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature zf-DHHC PF01529.15 EDK41649.2 - 1.6e-34 118.8 8.6 2.6e-34 118.1 6.0 1.3 1 1 0 1 1 1 1 DHHC palmitoyltransferase AhpC-TSA PF00578.16 EDK41650.1 - 5.8e-36 122.8 0.0 8e-36 122.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 EDK41650.1 - 1.2e-16 60.6 0.0 1.5e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 EDK41650.1 - 3.1e-12 45.9 0.1 5.4e-12 45.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF2951 PF11166.3 EDK41651.2 - 0.016 15.0 5.1 0.016 15.0 3.5 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) PMC2NT PF08066.7 EDK41651.2 - 0.14 12.4 3.8 1 9.7 2.1 2.8 1 1 1 2 2 2 0 PMC2NT (NUC016) domain PI3_PI4_kinase PF00454.22 EDK41652.2 - 8.7e-48 162.8 0.0 2.4e-47 161.3 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 EDK41652.2 - 7e-29 100.5 1.5 7e-29 100.5 1.0 2.4 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 EDK41652.2 - 2.3e-14 52.5 0.1 8.4e-14 50.7 0.0 2.1 2 0 0 2 2 2 1 FATC domain GCV_T PF01571.16 EDK41653.2 - 1.2e-59 201.2 0.0 1.6e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 EDK41653.2 - 2.2e-16 59.6 0.0 3.6e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.7 EDK41653.2 - 7e-06 25.9 0.0 0.025 14.4 0.0 2.4 1 1 1 2 2 2 2 Sarcosine oxidase, gamma subunit family Acetyltransf_9 PF13527.1 EDK41655.2 - 4.1e-05 23.4 0.0 0.0018 18.0 0.0 2.7 2 1 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 EDK41655.2 - 0.0011 19.1 0.1 0.0034 17.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Ubiq_cyt_C_chap PF03981.7 EDK41656.1 - 4.8e-40 136.6 0.1 1e-39 135.5 0.1 1.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone Aldo_ket_red PF00248.16 EDK41657.1 - 4.5e-43 147.0 0.0 5.1e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F_bP_aldolase PF01116.15 EDK41657.1 - 0.0045 16.1 0.0 0.0075 15.3 0.0 1.4 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Zn_clus PF00172.13 EDK41658.2 - 0.00019 21.2 13.1 0.00032 20.5 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF148 PF02520.12 EDK41658.2 - 0.093 12.5 2.2 0.27 11.0 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF148 Dickkopf_N PF04706.7 EDK41658.2 - 0.54 10.4 10.7 1.1 9.4 7.4 1.5 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region adh_short PF00106.20 EDK41659.1 - 8.9e-06 25.7 0.3 3.7e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EDK41659.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 1 0 1 1 1 0 NADH(P)-binding Toprim_Crpt PF13342.1 EDK41659.1 - 0.095 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Oxidored_FMN PF00724.15 EDK41660.1 - 8.1e-104 347.2 0.0 9.2e-104 347.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF3085 PF11284.3 EDK41660.1 - 0.053 13.7 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) SBF PF01758.11 EDK41661.2 - 3.4e-38 130.9 18.9 3.4e-38 130.9 13.1 2.2 1 1 0 2 2 2 1 Sodium Bile acid symporter family Oxidored_FMN PF00724.15 EDK41662.2 - 8e-106 353.8 0.0 9.1e-106 353.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.15 EDK41663.2 - 7.6e-100 334.2 0.0 8.8e-100 334.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.15 EDK41664.1 - 4.9e-109 364.4 0.0 5.6e-109 364.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.15 EDK41665.1 - 1.3e-107 359.7 0.0 1.5e-107 359.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ADH_N PF08240.7 EDK41666.2 - 3.3e-25 87.9 2.8 5.8e-25 87.1 1.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 EDK41666.2 - 4.2e-11 42.4 0.0 6.8e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 EDK41666.2 - 9.8e-06 24.8 0.0 1.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 EDK41666.2 - 0.00035 20.1 0.5 0.00066 19.2 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.16 EDK41666.2 - 0.02 14.4 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_2 PF03446.10 EDK41666.2 - 0.031 14.1 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase WAC_Acf1_DNA_bd PF10537.4 EDK41667.2 - 7.1e-41 138.5 1.6 2.4e-40 136.8 1.1 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 EDK41667.2 - 8.4e-10 38.2 0.1 2.3e-09 36.8 0.1 1.8 1 0 0 1 1 1 1 DDT domain WHIM2 PF15613.1 EDK41667.2 - 7.3e-07 28.8 0.2 2.3e-06 27.3 0.1 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 WHIM3 PF15614.1 EDK41667.2 - 4.8e-06 26.2 0.0 3.5e-05 23.4 0.1 2.5 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 3 IncA PF04156.9 EDK41667.2 - 6.2 6.3 11.4 0.54 9.8 4.1 2.1 2 0 0 2 2 2 0 IncA protein SKIP_SNW PF02731.10 EDK41668.2 - 1.1e-52 177.7 11.2 1.1e-52 177.7 7.8 1.8 2 0 0 2 2 2 1 SKIP/SNW domain DUF2193 PF09959.4 EDK41668.2 - 0.097 10.9 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) GDPD PF03009.12 EDK41669.2 - 1e-20 74.3 0.4 6.3e-20 71.7 0.3 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family ACT_7 PF13840.1 EDK41669.2 - 0.028 13.9 0.0 0.066 12.7 0.0 1.6 1 0 0 1 1 1 0 ACT domain Peptidase_A2B PF12384.3 EDK41669.2 - 0.072 12.4 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Ty3 transposon peptidase NUDIX PF00293.23 EDK41670.2 - 3.3e-09 36.5 0.0 5.5e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.6 EDK41670.2 - 2.2e-06 27.0 0.3 3.9e-06 26.2 0.2 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.6 EDK41670.2 - 9.3e-06 25.9 0.0 2.4e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain DNA_ligase_ZBD PF03119.11 EDK41670.2 - 0.02 14.5 0.4 0.049 13.3 0.3 1.7 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_ribbon_recom PF13408.1 EDK41670.2 - 0.12 12.6 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DEAD PF00270.24 EDK41671.2 - 3.4e-25 88.4 0.0 2e-24 85.9 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 EDK41671.2 - 1.1e-13 50.7 0.0 3.4e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 EDK41671.2 - 6.9e-09 35.7 0.0 3e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 EDK41671.2 - 0.055 13.6 0.5 5.1 7.2 0.1 3.4 2 2 1 3 3 3 0 AAA domain UvrD-helicase PF00580.16 EDK41671.2 - 0.06 12.6 0.1 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain DAP3 PF10236.4 EDK41672.2 - 3.8e-63 213.2 0.2 6.2e-63 212.5 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_5 PF07728.9 EDK41672.2 - 0.00021 21.0 0.0 0.00059 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 EDK41672.2 - 0.00068 19.6 0.1 0.0019 18.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 EDK41672.2 - 0.0017 17.5 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 EDK41672.2 - 0.0093 15.4 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.8 EDK41672.2 - 0.015 14.2 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Miro PF08477.8 EDK41672.2 - 0.023 15.1 0.0 0.12 12.8 0.0 2.2 2 0 0 2 2 2 0 Miro-like protein ABC_tran PF00005.22 EDK41672.2 - 0.057 13.7 0.0 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter UPF0113 PF03657.8 EDK41673.1 - 6.8e-11 42.0 0.0 9.1e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) Nol1_Nop2_Fmu_2 PF13636.1 EDK41673.1 - 0.056 13.5 0.0 0.089 12.8 0.0 1.4 1 1 0 1 1 1 0 pre-rRNA processing and ribosome biogenesis PUA PF01472.15 EDK41673.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 1 0 1 1 1 0 PUA domain PseudoU_synth_1 PF01416.15 EDK41674.2 - 6.6e-23 81.1 0.0 5.4e-11 42.8 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.4 EDK41674.2 - 0.038 13.4 0.0 0.064 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Pkinase PF00069.20 EDK41675.2 - 1.7e-39 135.5 0.0 2.9e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41675.2 - 1.2e-14 54.0 0.0 2e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 EDK41675.2 - 2.4e-06 27.4 0.0 0.0033 17.1 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family CENP-T PF15511.1 EDK41676.2 - 0.14 11.4 14.4 0.15 11.2 10.0 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T ASFV_J13L PF05568.6 EDK41676.2 - 3.7 7.0 11.8 5 6.6 8.2 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein Pkinase PF00069.20 EDK41677.2 - 2.1e-55 187.7 0.0 2.3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41677.2 - 3e-34 118.2 0.0 3.5e-34 118.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 EDK41677.2 - 1.5e-08 33.9 0.0 1.7e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 EDK41677.2 - 0.0029 16.6 0.0 0.004 16.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SCA7 PF08313.7 EDK41678.2 - 4.5e-33 112.6 0.4 4.5e-33 112.6 0.3 1.8 2 0 0 2 2 2 1 SCA7, zinc-binding domain Sgf11 PF08209.6 EDK41678.2 - 0.0001 21.4 0.6 0.00019 20.7 0.4 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Alpha_GJ PF03229.8 EDK41678.2 - 6.2 7.1 13.2 0.23 11.8 0.9 2.9 1 1 1 2 2 2 0 Alphavirus glycoprotein J Radical_SAM PF04055.16 EDK41679.2 - 8.9e-23 81.2 0.0 2.2e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 EDK41679.2 - 1.5e-21 76.2 0.0 4.3e-21 74.7 0.0 1.9 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 EDK41679.2 - 1.4e-15 57.4 0.0 2.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin Glycos_transf_1 PF00534.15 EDK41680.2 - 5.4e-27 94.3 0.0 1.1e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 EDK41680.2 - 2.3e-06 27.4 0.1 2.6e-05 24.0 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 EDK41680.2 - 0.00095 19.3 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EDK41680.2 - 0.0012 18.9 0.0 0.0069 16.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 EDK41680.2 - 0.039 14.0 0.0 0.069 13.2 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain DUF1414 PF07208.6 EDK41680.2 - 0.077 12.7 0.2 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) DUF1992 PF09350.5 EDK41681.2 - 7.1e-20 70.6 0.0 2.5e-19 68.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DUF1604 PF07713.8 EDK41683.2 - 0.039 13.7 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) WAC_Acf1_DNA_bd PF10537.4 EDK41684.1 - 0.06 13.5 0.2 0.11 12.6 0.2 1.4 1 1 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal Cwf_Cwc_15 PF04889.7 EDK41684.1 - 0.15 11.7 3.3 0.2 11.3 2.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Arf PF00025.16 EDK41685.2 - 9.2e-48 161.7 0.0 1e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 EDK41685.2 - 5.5e-08 31.8 0.0 9.1e-08 31.1 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Miro PF08477.8 EDK41685.2 - 0.00017 22.1 0.0 0.00023 21.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 EDK41685.2 - 0.00032 19.9 0.0 0.0004 19.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 EDK41685.2 - 0.00075 18.9 0.0 0.00083 18.7 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.22 EDK41685.2 - 0.13 11.6 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK41686.2 - 2.1e-16 59.9 0.0 1.1e-14 54.3 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK41686.2 - 3.1e-06 26.5 0.0 2.3e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 EDK41686.2 - 0.00085 18.5 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 EDK41686.2 - 0.015 15.1 0.2 0.033 14.0 0.1 1.8 1 1 0 1 1 1 0 Dynamin family AIG1 PF04548.11 EDK41686.2 - 0.017 14.1 0.0 0.035 13.2 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Miro PF08477.8 EDK41686.2 - 0.04 14.3 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Arg_repressor PF01316.16 EDK41686.2 - 0.075 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain FtsJ PF01728.14 EDK41687.2 - 5.3e-26 91.7 0.0 1e-25 90.7 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ribosomal_L1 PF00687.16 EDK41688.1 - 1.4e-44 152.1 4.5 1.8e-44 151.7 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Coatomer_WDAD PF04053.9 EDK41689.2 - 3.8e-171 569.7 1.3 3.8e-171 569.7 0.9 1.7 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.27 EDK41689.2 - 5.2e-46 152.9 10.4 2.3e-10 39.9 0.0 8.9 9 0 0 9 9 9 5 WD domain, G-beta repeat Nup160 PF11715.3 EDK41689.2 - 0.00065 17.9 6.4 0.07 11.2 0.1 4.8 3 1 1 5 5 5 2 Nucleoporin Nup120/160 Glycos_transf_1 PF00534.15 EDK41690.2 - 4.4e-16 58.7 0.0 9.5e-16 57.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 EDK41690.2 - 6.1e-05 23.1 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Peptidase_M24 PF00557.19 EDK41692.2 - 1e-44 152.6 0.5 1.4e-44 152.1 0.4 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Dicty_REP PF05086.7 EDK41692.2 - 2.1 5.9 4.6 2.7 5.6 3.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Phage_tube PF04985.9 EDK41693.2 - 0.04 13.3 1.5 0.055 12.8 1.1 1.1 1 0 0 1 1 1 0 Phage tail tube protein FII MatP PF06303.7 EDK41693.2 - 0.15 11.9 8.0 0.3 10.9 5.6 1.5 1 1 0 1 1 1 0 Organiser of macrodomain of Terminus of chromosome DUF2589 PF11655.3 EDK41693.2 - 0.18 11.9 3.6 0.24 11.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2589) CAF-1_p150 PF11600.3 EDK41693.2 - 0.46 9.8 9.7 0.61 9.4 6.7 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal LPP20 PF02169.11 EDK41693.2 - 1.6 8.9 6.7 2.4 8.3 4.6 1.4 1 0 0 1 1 1 0 LPP20 lipoprotein Mucin PF01456.12 EDK41693.2 - 2.4 7.9 18.3 3.4 7.4 12.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Aa_trans PF01490.13 EDK41694.2 - 7.2e-53 179.5 2.8 8.7e-53 179.2 2.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AOX PF01786.12 EDK41695.2 - 7.4e-88 293.3 0.1 9e-88 293.0 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase SH3_9 PF14604.1 EDK41696.2 - 1.6e-08 33.9 0.0 2.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 EDK41696.2 - 3.9e-08 32.5 0.1 7.1e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 EDK41696.2 - 6e-08 32.0 0.0 1.1e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain YfhO PF09586.5 EDK41696.2 - 0.01 13.9 0.1 0.013 13.5 0.1 1.1 1 0 0 1 1 1 1 Bacterial membrane protein YfhO Hydantoinase_B PF02538.9 EDK41697.2 - 4.7e-123 411.2 0.2 8.6e-123 410.3 0.1 1.4 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Aldo_ket_red PF00248.16 EDK41697.2 - 2.3e-52 177.5 0.0 8.5e-52 175.7 0.0 1.9 2 0 0 2 2 2 1 Aldo/keto reductase family Hydantoinase_A PF01968.13 EDK41697.2 - 8.6e-28 97.2 0.0 2.1e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 EDK41698.1 - 4.8e-55 185.7 0.1 4.8e-55 185.7 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.13 EDK41698.1 - 5.5e-22 78.2 0.1 2.2e-20 72.9 0.0 2.2 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Radical_SAM PF04055.16 EDK41698.1 - 0.0062 16.7 0.5 0.06 13.5 0.1 2.4 2 1 0 2 2 2 1 Radical SAM superfamily DAO PF01266.19 EDK41699.2 - 4.6e-23 81.7 0.0 6.8e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 EDK41699.2 - 3.3e-05 22.9 0.4 6.4e-05 21.9 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 EDK41699.2 - 5.7e-05 22.3 0.0 8.7e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 EDK41699.2 - 0.00051 19.9 0.0 0.021 14.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 EDK41699.2 - 0.00055 19.6 0.0 0.00097 18.8 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.1 EDK41699.2 - 0.00085 19.1 0.2 1.1 8.9 0.2 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 EDK41699.2 - 0.00089 19.2 0.0 0.0026 17.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 EDK41699.2 - 0.002 17.2 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.14 EDK41699.2 - 0.0029 16.7 0.1 0.34 10.0 0.0 2.9 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 EDK41699.2 - 0.0047 17.0 0.0 0.52 10.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 EDK41699.2 - 0.011 15.1 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 EDK41699.2 - 0.012 16.0 0.0 0.041 14.2 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 EDK41699.2 - 0.042 13.4 0.1 0.1 12.1 0.1 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 EDK41699.2 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TPMT PF05724.6 EDK41699.2 - 0.086 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MFS_1 PF07690.11 EDK41700.2 - 1.9e-33 115.6 28.9 2.5e-33 115.2 20.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1228 PF06779.9 EDK41700.2 - 0.00027 20.9 5.1 0.0008 19.3 0.8 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1228) FAD_binding_6 PF00970.19 EDK41701.2 - 3.5e-14 52.7 0.0 6.5e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.17 EDK41701.2 - 9.1e-10 38.8 0.0 2.3e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 Globin NAD_binding_1 PF00175.16 EDK41701.2 - 1.4e-09 38.5 0.0 3.2e-08 34.1 0.0 2.8 2 1 1 3 3 3 1 Oxidoreductase NAD-binding domain DUF3221 PF11518.3 EDK41701.2 - 0.015 14.9 0.2 4.9 6.8 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3221) Protoglobin PF11563.3 EDK41701.2 - 0.035 13.7 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Protoglobin NAD_binding_6 PF08030.7 EDK41701.2 - 0.079 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Bac_globin PF01152.16 EDK41701.2 - 0.12 12.4 0.1 1.1 9.2 0.0 2.6 2 1 0 2 2 2 0 Bacterial-like globin Epimerase PF01370.16 EDK41702.1 - 2.8e-19 69.4 0.1 3.8e-19 69.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 EDK41702.1 - 9.5e-14 50.7 0.1 1.3e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 EDK41702.1 - 6.3e-12 45.8 0.2 1.1e-11 45.0 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 EDK41702.1 - 1.7e-11 43.5 0.1 1.8e-09 36.9 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 EDK41702.1 - 3.5e-05 23.1 0.8 0.0028 16.9 0.2 2.2 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 EDK41702.1 - 7.9e-05 22.6 0.1 0.00016 21.6 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 EDK41702.1 - 0.00014 20.9 0.1 0.029 13.2 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EDK41702.1 - 0.00078 18.4 0.4 0.0017 17.3 0.3 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 EDK41702.1 - 0.0028 18.0 0.0 0.0071 16.7 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 EDK41702.1 - 0.012 15.5 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.5 EDK41702.1 - 0.017 14.7 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 KR domain DcuC PF03606.10 EDK41705.2 - 0.01 14.0 1.4 0.016 13.4 0.9 1.2 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF1625 PF07787.7 EDK41705.2 - 1.1 8.5 6.1 0.75 8.9 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1625) Abhydrolase_6 PF12697.2 EDK41706.2 - 8.3e-32 110.9 0.0 1e-31 110.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41706.2 - 1.5e-18 67.2 0.0 2.8e-18 66.3 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK41706.2 - 9.4e-12 44.9 0.0 1.7e-11 44.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 EDK41706.2 - 0.00017 21.2 0.0 0.00063 19.3 0.0 1.9 1 1 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.15 EDK41706.2 - 0.00057 20.1 0.0 0.0008 19.6 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain Esterase PF00756.15 EDK41706.2 - 0.0027 17.1 0.0 0.0049 16.3 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.3 EDK41706.2 - 0.0096 15.7 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DUF676 PF05057.9 EDK41706.2 - 0.041 13.1 0.0 0.076 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF1057 PF06342.7 EDK41706.2 - 0.11 11.2 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.13 EDK41706.2 - 0.13 11.4 0.0 3.2 6.9 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family CN_hydrolase PF00795.17 EDK41707.2 - 1.8e-29 102.3 0.0 7.2e-29 100.4 0.0 1.7 1 1 0 2 2 2 1 Carbon-nitrogen hydrolase YoaP PF14268.1 EDK41707.2 - 0.22 10.7 0.6 0.46 9.7 0.4 1.5 1 0 0 1 1 1 0 YoaP-like MFS_1 PF07690.11 EDK41708.2 - 7.5e-36 123.5 45.4 2.9e-35 121.6 30.4 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Mannosyl_trans3 PF11051.3 EDK41709.2 - 5.3e-84 281.7 0.0 7.6e-84 281.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Sas10 PF09368.5 EDK41709.2 - 0.074 13.2 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 Sas10 C-terminal domain UPF0061 PF02696.9 EDK41710.2 - 8.3e-117 390.4 0.0 1e-116 390.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Bul1_N PF04425.7 EDK41712.2 - 9.4e-122 406.7 10.5 9.4e-122 406.7 7.3 1.5 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 EDK41712.2 - 7.9e-16 58.0 12.8 4.1e-08 32.7 0.5 3.3 2 1 1 3 3 3 2 Bul1 C terminus Transp_cyt_pur PF02133.10 EDK41713.2 - 5.2e-10 38.4 41.6 2.7e-09 36.0 28.8 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF3508 PF12018.3 EDK41713.2 - 0.095 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) Zn_clus PF00172.13 EDK41714.2 - 2.9e-05 23.8 10.4 4.9e-05 23.1 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mannosyl_trans3 PF11051.3 EDK41715.2 - 1.3e-74 251.0 0.3 1.3e-74 251.0 0.2 1.8 2 0 0 2 2 2 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 EDK41715.2 - 0.00026 20.4 3.1 0.0008 18.8 2.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Amidase PF01425.16 EDK41716.2 - 1.4e-85 287.7 0.0 1.7e-85 287.5 0.0 1.0 1 0 0 1 1 1 1 Amidase GTP_EFTU PF00009.22 EDK41717.2 - 9e-45 152.4 0.1 1.4e-44 151.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 EDK41717.2 - 1.9e-06 27.7 0.1 1.8e-05 24.6 0.0 2.7 3 1 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 EDK41717.2 - 7.1e-06 25.5 0.0 2.5e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D3 PF03143.12 EDK41717.2 - 0.00024 21.1 0.3 0.0014 18.8 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 EDK41717.2 - 0.001 19.1 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 EDK41717.2 - 0.019 15.4 0.1 0.38 11.2 0.1 2.6 1 1 0 1 1 1 0 Miro-like protein Syntaxin-18_N PF10496.4 EDK41718.2 - 5.3e-19 67.8 0.4 7.2e-18 64.2 0.0 2.7 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Methyltransf_3 PF01596.12 EDK41719.2 - 1.4e-22 79.7 0.0 1.8e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 EDK41719.2 - 3.5e-12 47.0 0.0 5.1e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK41719.2 - 1.6e-07 31.8 0.0 2.8e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 EDK41719.2 - 0.0031 16.8 0.0 0.0067 15.7 0.0 1.5 1 1 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_26 PF13659.1 EDK41719.2 - 0.05 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain SYF2 PF08231.7 EDK41720.2 - 3.4e-14 53.2 21.2 3.4e-14 53.2 14.7 2.0 1 1 1 2 2 2 1 SYF2 splicing factor MT-A70 PF05063.9 EDK41720.2 - 0.058 12.9 1.4 0.093 12.2 1.0 1.4 1 0 0 1 1 1 0 MT-A70 SH2_2 PF14633.1 EDK41721.2 - 4.4e-68 228.6 0.3 4.4e-68 228.6 0.2 2.6 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.1 EDK41721.2 - 1.5e-35 121.9 0.0 4.5e-35 120.4 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 DLD PF14878.1 EDK41721.2 - 3.4e-35 120.5 3.3 3.4e-35 120.5 2.3 4.8 6 0 0 6 6 6 1 Death-like domain of SPT6 HHH_7 PF14635.1 EDK41721.2 - 3.7e-29 100.8 0.1 1e-28 99.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.1 EDK41721.2 - 3e-22 78.8 3.0 3e-22 78.8 2.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.1 EDK41721.2 - 1.5e-19 69.9 25.4 1.5e-19 69.9 17.6 5.0 5 0 0 5 5 5 2 Acidic N-terminal SPT6 TauD PF02668.11 EDK41722.2 - 7.6e-56 189.6 0.0 1e-55 189.1 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 EDK41722.2 - 0.021 15.2 0.0 0.082 13.3 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF971) DUF1212 PF06738.7 EDK41723.2 - 3.7e-47 160.2 10.4 2.6e-46 157.5 0.6 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 EDK41723.2 - 4.8e-25 87.9 9.4 4.8e-25 87.9 6.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3815) PDCD2_C PF04194.8 EDK41724.2 - 9.1e-38 129.4 1.5 3.7e-35 120.9 0.0 2.8 3 0 0 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain Ydc2-catalyt PF09159.5 EDK41724.2 - 0.099 12.1 0.9 0.14 11.5 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 GTP_EFTU PF00009.22 EDK41725.2 - 4.3e-37 127.3 4.4 4.3e-37 127.3 3.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EDK41725.2 - 5.6e-25 87.3 0.7 1.6e-24 85.8 0.5 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EDK41725.2 - 2.5e-12 46.7 0.9 3e-06 27.2 0.0 3.1 2 0 0 2 2 2 2 Elongation factor Tu domain 2 IF2_N PF04760.10 EDK41725.2 - 3.7e-12 45.7 0.0 6e-11 41.8 0.0 2.9 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.18 EDK41725.2 - 3.3e-07 30.2 0.2 1.4e-06 28.2 0.1 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 EDK41725.2 - 5.6e-07 30.0 0.3 1.7e-06 28.4 0.2 1.9 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 EDK41725.2 - 0.0014 17.8 0.7 0.0025 17.0 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.17 EDK41725.2 - 0.0019 17.6 0.2 0.0044 16.4 0.1 1.6 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 EDK41725.2 - 0.0047 16.1 0.3 0.0047 16.1 0.2 2.3 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Hydrolase_6 PF13344.1 EDK41725.2 - 0.0054 16.5 0.1 1.2 9.0 0.0 3.7 3 2 0 3 3 3 1 Haloacid dehalogenase-like hydrolase FeoB_N PF02421.13 EDK41725.2 - 0.025 13.8 0.2 0.05 12.8 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF2924 PF11149.3 EDK41725.2 - 0.063 13.3 1.6 0.15 12.0 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) Dynamin_N PF00350.18 EDK41725.2 - 0.92 9.2 8.6 6.6 6.5 0.0 3.7 3 1 1 4 4 4 0 Dynamin family Dfp1_Him1_M PF08630.5 EDK41726.2 - 2.6e-41 140.3 0.0 5.3e-41 139.2 0.0 1.6 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.7 EDK41726.2 - 1.2e-22 79.2 1.9 2.1e-22 78.5 1.3 1.4 1 0 0 1 1 1 1 DBF zinc finger Coprogen_oxidas PF01218.13 EDK41727.2 - 0.036 12.6 0.1 0.05 12.1 0.1 1.2 1 0 0 1 1 1 0 Coproporphyrinogen III oxidase UQ_con PF00179.21 EDK41728.2 - 2.5e-41 140.3 0.0 3.1e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 EDK41728.2 - 0.0005 19.8 0.0 0.0018 18.0 0.0 1.8 1 1 0 1 1 1 1 Prokaryotic E2 family B SH3BGR PF04908.10 EDK41729.2 - 1.5e-07 31.2 1.1 2.1e-06 27.6 0.0 3.3 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.19 EDK41729.2 - 0.017 15.1 0.1 0.095 12.7 0.0 2.3 2 0 0 2 2 2 0 Glutaredoxin KH_1 PF00013.24 EDK41730.2 - 3.7e-67 221.8 37.4 1.4e-11 43.8 0.1 11.6 13 0 0 13 13 13 9 KH domain KH_3 PF13014.1 EDK41730.2 - 4.4e-44 147.4 20.7 7.9e-09 34.9 0.1 10.3 10 1 0 10 10 10 7 KH domain KH_4 PF13083.1 EDK41730.2 - 2.4e-06 27.1 0.8 5.8 6.6 0.0 5.5 4 0 0 4 4 4 3 KH domain KH_2 PF07650.12 EDK41730.2 - 0.0001 21.7 15.9 0.89 9.1 0.0 6.9 8 0 0 8 8 8 3 KH domain BMC PF00936.14 EDK41730.2 - 0.032 13.8 0.1 33 4.2 0.0 4.1 4 0 0 4 4 4 0 BMC domain FAD_binding_7 PF03441.9 EDK41731.2 - 2.9e-94 315.3 0.2 4.9e-94 314.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 EDK41731.2 - 2.8e-34 118.2 0.1 5.3e-34 117.3 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase AA_permease_2 PF13520.1 EDK41732.2 - 1.7e-91 306.9 47.4 2.1e-91 306.6 32.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 EDK41732.2 - 1.4e-17 63.2 38.7 1.8e-17 62.8 26.8 1.1 1 0 0 1 1 1 1 Amino acid permease L51_S25_CI-B8 PF05047.11 EDK41733.2 - 4.4e-06 26.3 0.0 7.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Zn_clus PF00172.13 EDK41734.2 - 0.0025 17.6 13.6 0.0025 17.6 9.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TauD PF02668.11 EDK41735.1 - 1.6e-50 172.2 0.8 2e-50 171.8 0.5 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TauD PF02668.11 EDK41736.1 - 7.2e-53 179.8 1.0 1.1e-52 179.2 0.4 1.5 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family EF-hand_4 PF12763.2 EDK41737.2 - 1e-25 89.4 0.0 1.2e-11 44.2 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand UBA PF00627.26 EDK41737.2 - 1.6e-09 37.3 0.5 3.9e-09 36.0 0.3 1.7 1 0 0 1 1 1 1 UBA/TS-N domain DUF2968 PF11180.3 EDK41737.2 - 0.00046 19.6 8.1 0.00046 19.6 5.6 3.4 1 1 2 3 3 2 1 Protein of unknown function (DUF2968) EF-hand_1 PF00036.27 EDK41737.2 - 0.0012 18.0 0.0 0.71 9.3 0.0 3.6 3 0 0 3 3 3 1 EF hand UBA_4 PF14555.1 EDK41737.2 - 0.0063 16.0 0.3 0.016 14.7 0.2 1.7 1 0 0 1 1 1 1 UBA-like domain EF-hand_7 PF13499.1 EDK41737.2 - 0.0065 16.5 0.0 0.04 14.0 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 EDK41737.2 - 0.033 14.0 0.0 0.26 11.2 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain DUF3584 PF12128.3 EDK41737.2 - 0.071 10.4 38.2 0.12 9.6 26.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Filament PF00038.16 EDK41737.2 - 0.51 9.7 38.6 0.97 8.8 26.8 1.4 1 0 0 1 1 1 0 Intermediate filament protein TPR_MLP1_2 PF07926.7 EDK41737.2 - 2.6 7.7 52.7 0.022 14.4 16.2 3.5 1 1 2 3 3 2 0 TPR/MLP1/MLP2-like protein GAS PF13851.1 EDK41737.2 - 6.3 5.9 45.4 2 7.5 9.3 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.1 EDK41737.2 - 9.4 5.6 40.2 0.033 13.6 15.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Gar1 PF04410.9 EDK41738.2 - 3e-44 150.1 0.3 3e-44 150.1 0.2 1.8 1 1 1 2 2 2 1 Gar1/Naf1 RNA binding region MMR_HSR1 PF01926.18 EDK41739.2 - 1.2e-16 60.6 0.0 2.4e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 EDK41739.2 - 1.6e-07 30.9 0.1 3.6e-06 26.5 0.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 EDK41739.2 - 1.3e-06 27.7 0.0 3e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 EDK41739.2 - 5.2e-06 26.3 0.1 0.06 13.1 0.1 2.5 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.13 EDK41739.2 - 1.2e-05 24.6 0.0 1.9e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 EDK41739.2 - 4.1e-05 22.8 0.0 6.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 EDK41739.2 - 0.016 15.0 0.0 0.054 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_DNA_bp PF00747.12 EDK41739.2 - 0.022 11.9 0.0 0.03 11.5 0.0 1.1 1 0 0 1 1 1 0 ssDNA binding protein Miro PF08477.8 EDK41739.2 - 0.03 14.8 0.0 0.071 13.6 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein AAA_22 PF13401.1 EDK41739.2 - 0.031 14.4 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.11 EDK41739.2 - 0.033 13.3 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 AIG1 family DUF1525 PF07511.6 EDK41739.2 - 0.087 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) PLDc PF00614.17 EDK41740.2 - 7.8e-17 60.4 0.4 2e-08 33.7 0.1 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 EDK41740.2 - 2.5e-13 49.8 0.1 1.7e-08 34.2 0.0 2.9 2 1 0 2 2 2 2 PLD-like domain Erv26 PF04148.8 EDK41741.2 - 5.5e-78 261.1 13.9 9.5e-78 260.3 9.7 1.3 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF2189 PF09955.4 EDK41741.2 - 0.086 12.7 6.1 4.1 7.3 4.2 2.7 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2189) DUF996 PF06195.8 EDK41741.2 - 0.27 11.2 5.4 0.5 10.3 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF996) CD20 PF04103.10 EDK41741.2 - 0.3 11.0 6.0 0.054 13.4 1.0 2.0 2 1 0 2 2 2 0 CD20-like family ST7 PF04184.7 EDK41741.2 - 0.44 8.7 2.6 0.7 8.0 1.8 1.2 1 0 0 1 1 1 0 ST7 protein Yip1 PF04893.12 EDK41741.2 - 3.2 7.2 12.4 4.3 6.8 7.5 2.0 1 1 0 1 1 1 0 Yip1 domain DUF1700 PF08006.6 EDK41741.2 - 6.5 6.0 8.1 0.4 9.9 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Abhydrolase_1 PF00561.15 EDK41742.2 - 5.6e-18 65.3 0.1 1.3e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 EDK41742.2 - 6.9e-10 39.1 0.0 1.3e-09 38.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 EDK41742.2 - 2e-05 24.1 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 EDK41742.2 - 0.082 12.1 0.0 0.57 9.3 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Scs3p PF10261.4 EDK41743.2 - 7.1e-44 149.6 7.3 1.3e-43 148.7 5.1 1.4 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM HMA PF00403.21 EDK41744.1 - 1.2e-05 25.3 8.6 0.0023 18.0 0.2 3.3 4 0 0 4 4 4 2 Heavy-metal-associated domain E1-E2_ATPase PF00122.15 EDK41745.2 - 1.4e-46 158.3 0.0 4e-46 156.9 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 EDK41745.2 - 5.5e-38 131.5 0.0 8.5e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 EDK41745.2 - 2.3e-18 67.0 0.0 4.9e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 EDK41745.2 - 0.011 15.3 0.1 0.081 12.4 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PP2C PF00481.16 EDK41746.2 - 6.1e-63 212.5 1.1 2e-49 168.2 0.2 2.7 2 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 EDK41746.2 - 0.0013 18.4 0.0 0.003 17.2 0.0 1.7 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) UPF0029 PF01205.14 EDK41746.2 - 0.056 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein family UPF0029 F-box-like PF12937.2 EDK41747.2 - 0.00092 18.8 0.1 0.0026 17.4 0.0 1.9 1 0 0 1 1 1 1 F-box-like Abhydrolase_6 PF12697.2 EDK41748.2 - 3.1e-09 37.0 0.0 3.6e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 EDK41748.2 - 0.00023 20.9 0.0 0.00034 20.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 EDK41748.2 - 0.024 14.1 0.0 0.048 13.2 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 EDK41748.2 - 0.11 11.7 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family DDE_1 PF03184.14 EDK41749.2 - 9.4e-37 126.2 1.1 2.6e-36 124.7 0.2 2.1 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 EDK41749.2 - 1.7e-15 56.5 0.1 4.4e-15 55.2 0.1 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_32 PF13565.1 EDK41749.2 - 0.015 16.0 0.0 0.051 14.3 0.0 1.9 1 0 0 1 1 1 0 Homeodomain-like domain DUF846 PF05832.7 EDK41751.2 - 4.9e-53 178.6 11.5 5.9e-53 178.3 8.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Clathrin PF00637.15 EDK41752.2 - 2.9e-29 101.5 6.4 1.5e-28 99.2 1.6 3.4 4 0 0 4 4 4 1 Region in Clathrin and VPS WD40 PF00400.27 EDK41752.2 - 0.0071 16.1 0.2 0.031 14.1 0.2 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat Tbf5 PF06331.7 EDK41753.1 - 3.6e-26 90.7 0.0 4e-26 90.5 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Sec34 PF04136.10 EDK41754.2 - 6e-32 110.5 1.7 6e-32 110.5 1.2 2.1 2 0 0 2 2 2 1 Sec34-like family Dor1 PF04124.7 EDK41754.2 - 0.015 13.8 7.1 0.018 13.5 2.3 2.6 2 1 0 2 2 2 0 Dor1-like family zf-primase PF09329.6 EDK41755.2 - 3.6e-11 42.4 2.8 6.2e-11 41.7 1.9 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 EDK41755.2 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain EamA PF00892.15 EDK41756.2 - 0.009 16.0 0.7 0.012 15.6 0.5 1.2 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 EDK41756.2 - 0.021 14.9 1.3 0.03 14.4 0.9 1.2 1 0 0 1 1 1 0 Multidrug resistance efflux transporter p450 PF00067.17 EDK41757.1 - 5.7e-65 219.6 0.0 7.3e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 UPF0160 PF03690.8 EDK41758.2 - 1e-125 419.4 0.0 1.1e-125 419.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Toprim_2 PF13155.1 EDK41758.2 - 0.1 12.9 0.1 0.25 11.7 0.1 1.8 1 0 0 1 1 1 0 Toprim-like MFS_1 PF07690.11 EDK41759.2 - 1e-13 50.7 8.1 1e-13 50.7 5.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1700 PF08006.6 EDK41759.2 - 1.2 8.3 7.0 0.23 10.7 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1700) Sugar_tr PF00083.19 EDK41761.1 - 1.2e-103 347.1 34.9 1.4e-103 346.8 24.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41761.1 - 1.3e-22 80.0 37.7 3.5e-22 78.5 23.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 EDK41762.1 - 1.4e-106 356.7 26.7 1.8e-106 356.4 18.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 EDK41762.1 - 4.7e-26 91.3 27.7 1.3e-25 89.8 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 EDK41763.2 - 4.2e-42 144.0 0.0 1.7e-35 122.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 EDK41763.2 - 3.3e-15 55.8 0.0 1.1e-12 47.6 0.0 3.0 1 1 1 2 2 2 1 Protein tyrosine kinase NotI PF12183.3 EDK41763.2 - 0.00045 19.3 0.7 0.0016 17.6 0.4 1.8 2 0 0 2 2 2 1 Restriction endonuclease NotI Pox_ser-thr_kin PF05445.6 EDK41763.2 - 0.017 13.9 0.0 0.039 12.7 0.0 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase PaRep2a PF07903.6 EDK41763.2 - 0.097 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 PaRep2a protein Kdo PF06293.9 EDK41763.2 - 0.13 11.2 0.1 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1669 PF07894.7 EDK41763.2 - 0.18 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1669) GalKase_gal_bdg PF10509.4 EDK41764.2 - 4e-22 77.2 0.0 7.4e-22 76.3 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 EDK41764.2 - 7.1e-15 54.8 0.3 1.9e-14 53.4 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 EDK41764.2 - 3.2e-09 36.8 0.0 6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal Aldose_epim PF01263.15 EDK41765.1 - 7.9e-67 225.4 0.5 1.1e-66 224.9 0.3 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase Epimerase PF01370.16 EDK41765.1 - 1e-47 162.5 0.0 1.4e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 EDK41765.1 - 2.6e-24 84.9 0.0 5.3e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Polysacc_synt_2 PF02719.10 EDK41765.1 - 3.2e-17 62.3 0.1 2.1e-15 56.4 0.1 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 EDK41765.1 - 3.5e-17 62.0 0.1 1.2e-16 60.2 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 EDK41765.1 - 1.9e-12 46.6 0.0 5.2e-12 45.2 0.0 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 EDK41765.1 - 1.5e-10 40.4 0.0 9.4e-09 34.5 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 EDK41765.1 - 1.6e-06 28.1 0.0 2.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 EDK41765.1 - 3.4e-06 27.2 0.0 6.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 EDK41765.1 - 6.3e-06 25.9 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 EDK41765.1 - 8e-05 21.9 0.2 0.00017 20.9 0.2 1.5 1 0 0 1 1 1 1 NmrA-like family UDPG_MGDP_dh_N PF03721.9 EDK41765.1 - 0.0032 16.8 0.1 0.015 14.7 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.19 EDK41765.1 - 0.068 12.0 0.7 0.11 11.3 0.5 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Sybindin PF04099.7 EDK41766.1 - 5.9e-37 126.5 2.0 3.1e-23 82.0 0.1 2.2 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.8 EDK41766.1 - 3.1e-09 36.8 0.1 3.5e-09 36.6 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Epimerase PF01370.16 EDK41767.2 - 1.2e-53 182.0 0.0 1.4e-53 181.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EDK41767.2 - 4e-18 65.2 0.0 7.6e-18 64.3 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 EDK41767.2 - 4.4e-12 45.4 0.0 8.4e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 EDK41767.2 - 6.4e-10 38.1 0.0 8.9e-10 37.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 EDK41767.2 - 1.7e-08 33.7 0.0 3e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EDK41767.2 - 0.002 18.0 0.0 0.026 14.4 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase Saccharop_dh PF03435.13 EDK41767.2 - 0.061 12.2 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 EDK41767.2 - 0.15 12.0 0.0 0.57 10.1 0.0 1.9 1 1 0 1 1 1 0 NADH(P)-binding GalP_UDP_transf PF01087.17 EDK41768.2 - 1.6e-66 223.8 0.1 3e-66 222.9 0.1 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.12 EDK41768.2 - 1.3e-62 210.2 0.9 2.7e-62 209.2 0.6 1.5 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.18 EDK41768.2 - 0.06 13.8 0.0 0.44 11.1 0.0 2.3 2 0 0 2 2 2 0 HIT domain Methyltransf_23 PF13489.1 EDK41769.2 - 6.7e-19 68.1 0.0 1.1e-18 67.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 EDK41769.2 - 9.8e-15 54.8 0.1 6.6e-14 52.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 EDK41769.2 - 5.5e-09 36.5 0.0 1.3e-08 35.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 EDK41769.2 - 6.6e-09 36.1 0.0 1.6e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 EDK41769.2 - 1.7e-08 34.1 0.0 5.2e-08 32.6 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 EDK41769.2 - 4.8e-07 30.0 0.0 1.2e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 EDK41769.2 - 4.7e-06 26.6 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 EDK41769.2 - 0.00015 20.8 0.0 0.38 9.6 0.0 2.2 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family DUF3419 PF11899.3 EDK41769.2 - 0.0026 16.5 0.0 0.0048 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) CMAS PF02353.15 EDK41769.2 - 0.0047 16.0 0.1 0.021 13.9 0.0 1.9 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase RRM_1 PF00076.17 EDK41769.2 - 0.0051 16.4 0.0 0.015 14.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CheR PF01739.13 EDK41769.2 - 0.011 15.0 0.0 3.5 6.8 0.0 2.3 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain MTS PF05175.9 EDK41769.2 - 0.023 14.1 0.0 0.058 12.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.8 EDK41769.2 - 0.13 11.3 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.1 EDK41769.2 - 0.18 11.4 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cullin PF00888.17 EDK41770.2 - 4.7e-92 309.4 5.1 4.7e-92 309.4 3.5 1.8 2 1 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 EDK41770.2 - 2.7e-26 91.1 3.6 2.7e-26 91.1 2.5 2.7 2 0 0 2 2 2 1 Cullin protein neddylation domain Mus7 PF09462.5 EDK41773.2 - 5.5e-36 124.6 11.9 3.7e-23 82.2 0.8 3.4 2 1 0 3 3 3 2 Mus7/MMS22 family 3Beta_HSD PF01073.14 EDK41775.2 - 2.8e-82 275.5 0.0 3.4e-82 275.3 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 EDK41775.2 - 1.2e-29 103.4 0.0 1.5e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 EDK41775.2 - 2.3e-19 69.3 0.0 5.7e-19 68.0 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 EDK41775.2 - 1.1e-11 45.1 0.0 1.7e-11 44.4 0.0 1.3 1 1 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 EDK41775.2 - 2.9e-11 42.7 0.0 4.2e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 EDK41775.2 - 6.6e-08 31.7 0.0 2.5e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 EDK41775.2 - 5.6e-06 26.3 0.0 1.4e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 EDK41775.2 - 0.00059 19.1 0.0 0.00085 18.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 EDK41775.2 - 0.015 14.9 0.0 0.093 12.3 0.0 2.0 1 1 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.19 EDK41775.2 - 0.047 13.9 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DB PF01682.14 EDK41776.2 - 0.042 13.8 8.9 0.073 13.1 6.1 1.4 1 0 0 1 1 1 0 DB module Glyco_hydro_72 PF03198.9 EDK41777.2 - 1.3e-135 451.4 10.5 1.7e-135 451.0 7.3 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 EDK41777.2 - 3.3e-27 94.7 5.7 1.1e-26 93.1 3.9 2.0 1 0 0 1 1 1 1 X8 domain G-patch PF01585.18 EDK41778.2 - 2.4e-11 43.2 0.1 9.7e-11 41.2 0.0 2.1 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.2 EDK41778.2 - 0.00014 21.6 0.0 0.00014 21.6 0.0 3.5 2 1 0 2 2 1 1 DExH-box splicing factor binding site SprA-related PF12118.3 EDK41778.2 - 0.0063 15.8 17.1 0.0074 15.6 11.8 1.2 1 0 0 1 1 1 1 SprA-related family FeoA PF04023.9 EDK41778.2 - 0.11 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 FeoA domain RR_TM4-6 PF06459.7 EDK41778.2 - 0.13 12.1 20.8 0.18 11.6 14.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MIP-T3 PF10243.4 EDK41778.2 - 0.3 9.4 44.9 0.4 9.0 31.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF2201_N PF13203.1 EDK41778.2 - 0.67 9.0 17.0 0.99 8.5 11.8 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF1510 PF07423.6 EDK41778.2 - 1 8.7 30.6 0.8 9.0 19.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 EDK41778.2 - 1.8 6.5 23.3 2.3 6.1 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein FLO_LFY PF01698.11 EDK41778.2 - 1.9 7.2 18.9 2.4 6.8 13.1 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Zip PF02535.17 EDK41778.2 - 4.7 6.1 10.2 6.3 5.7 7.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter APG6 PF04111.7 EDK41778.2 - 5.8 5.8 20.1 7.8 5.4 13.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 N6-adenineMlase PF10237.4 EDK41779.2 - 5.6e-60 201.6 0.1 5.6e-60 201.6 0.1 1.4 2 0 0 2 2 2 1 Probable N6-adenine methyltransferase B-block_TFIIIC PF04182.7 EDK41780.2 - 5.8e-22 77.3 0.1 2.3e-20 72.2 0.0 3.3 4 0 0 4 4 4 1 B-block binding subunit of TFIIIC MarR_2 PF12802.2 EDK41780.2 - 5e-05 22.8 0.0 0.00053 19.6 0.0 2.4 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.1 EDK41780.2 - 0.00029 21.0 0.0 0.0015 18.8 0.0 2.3 2 0 0 2 2 2 1 Winged helix DNA-binding domain TFIIE_beta PF02186.10 EDK41780.2 - 0.0072 16.2 0.1 0.25 11.3 0.1 2.7 2 0 0 2 2 2 1 TFIIE beta subunit core domain MarR PF01047.17 EDK41780.2 - 0.014 15.0 0.0 0.053 13.2 0.0 2.0 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.2 EDK41780.2 - 0.073 12.8 0.0 0.57 10.0 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain SNF5 PF04855.7 EDK41781.2 - 5.8e-58 196.2 2.3 1.6e-56 191.5 0.4 2.4 2 1 0 2 2 2 1 SNF5 / SMARCB1 / INI1 dCMP_cyt_deam_1 PF00383.17 EDK41782.2 - 9e-07 28.4 0.1 1.6e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region HCNGP PF07818.8 EDK41782.2 - 0.007 16.3 0.3 0.032 14.2 0.2 2.1 1 0 0 1 1 1 1 HCNGP-like protein Telomerase_RBD PF12009.3 EDK41783.2 - 6.5e-34 116.7 2.1 2.8e-33 114.6 0.4 2.7 3 0 0 3 3 3 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 EDK41783.2 - 2.5e-11 43.3 0.4 1.2e-10 41.0 0.3 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AIP3 PF03915.8 EDK41784.2 - 2.9e-156 520.6 20.0 2.9e-156 520.6 13.8 2.2 3 0 0 3 3 3 1 Actin interacting protein 3 Syntaxin_2 PF14523.1 EDK41784.2 - 0.017 15.1 0.1 0.017 15.1 0.1 4.4 4 1 1 5 5 5 0 Syntaxin-like protein HEAT PF02985.17 EDK41785.2 - 0.037 14.1 0.3 0.6 10.3 0.0 3.0 3 0 0 3 3 3 0 HEAT repeat Peptidase_C65 PF10275.4 EDK41785.2 - 0.15 11.3 0.0 0.32 10.2 0.0 1.5 2 0 0 2 2 2 0 Peptidase C65 Otubain HEAT_2 PF13646.1 EDK41785.2 - 0.2 11.9 2.0 3.5 7.9 0.4 2.9 1 1 2 3 3 3 0 HEAT repeats HEAT_2 PF13646.1 EDK41787.2 - 9.6e-06 25.7 1.6 0.00042 20.5 0.0 3.4 2 1 1 4 4 4 1 HEAT repeats HEAT PF02985.17 EDK41787.2 - 5.5e-05 22.9 4.1 0.029 14.4 0.0 4.5 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 EDK41787.2 - 0.018 15.5 3.3 2.2 8.8 0.0 4.3 3 2 2 5 5 5 0 HEAT-like repeat CLASP_N PF12348.3 EDK41787.2 - 0.022 14.1 0.5 1.2 8.4 0.1 2.9 3 1 0 3 3 3 0 CLASP N terminal IBN_N PF03810.14 EDK41787.2 - 0.023 14.6 0.0 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 Importin-beta N-terminal domain Tfb2 PF03849.9 EDK41787.2 - 0.065 11.8 0.0 0.17 10.5 0.0 1.7 2 0 0 2 2 2 0 Transcription factor Tfb2 ParcG PF10274.4 EDK41787.2 - 0.084 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Parkin co-regulated protein TGS PF02824.16 EDK41788.1 - 3.1e-22 78.1 0.0 6.2e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 EDK41788.1 - 6.5e-18 64.7 0.5 1.6e-17 63.5 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 EDK41788.1 - 1.5e-09 37.3 0.0 3.3e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 EDK41788.1 - 0.00084 19.1 0.5 0.7 9.6 0.0 2.4 1 1 1 2 2 2 2 Dynamin family ArgK PF03308.11 EDK41788.1 - 0.0049 15.6 0.2 0.012 14.4 0.2 1.6 1 0 0 1 1 1 1 ArgK protein Miro PF08477.8 EDK41788.1 - 0.021 15.3 0.1 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein Arf PF00025.16 EDK41788.1 - 0.09 12.0 0.2 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.22 EDK41789.2 - 7.9e-32 110.2 0.0 7.5e-31 107.0 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 EDK41789.2 - 1.1e-20 73.5 0.0 4.1e-20 71.6 0.0 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 EDK41789.2 - 4.5e-12 45.9 0.7 3.3e-08 33.5 0.0 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 EDK41789.2 - 1.3e-06 28.3 0.1 8.1e-06 25.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 EDK41789.2 - 0.0018 17.8 0.2 0.016 14.7 0.0 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 EDK41789.2 - 0.0021 17.9 0.4 0.0021 17.9 0.3 4.3 4 0 0 4 4 4 1 Dynamin family GTP_EFTU_D4 PF14578.1 EDK41789.2 - 0.0054 16.3 0.1 0.017 14.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 AAA_22 PF13401.1 EDK41789.2 - 0.0058 16.7 0.1 0.035 14.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain Hydrolase_6 PF13344.1 EDK41790.2 - 9.7e-28 96.0 0.0 2e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 EDK41790.2 - 2e-15 56.2 0.0 3.9e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 EDK41790.2 - 8e-10 39.4 0.0 7.2e-09 36.3 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 EDK41790.2 - 0.0015 18.7 0.1 0.56 10.3 0.1 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hpt PF01627.18 EDK41791.1 - 1.1e-10 41.4 0.0 2.6e-10 40.1 0.0 1.6 1 1 0 1 1 1 1 Hpt domain DUF2524 PF10732.4 EDK41791.1 - 0.096 12.8 0.2 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) CitX PF03802.9 EDK41791.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Glyco_transf_22 PF03901.12 EDK41792.2 - 2.3e-80 270.6 28.6 2.9e-80 270.3 19.8 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AA_permease PF00324.16 EDK41793.2 - 2.4e-130 435.1 48.5 2.7e-130 434.9 33.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 EDK41793.2 - 5.9e-36 123.9 50.1 6.8e-36 123.7 34.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF98 PF01947.11 EDK41793.2 - 0.054 13.2 0.1 0.091 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF98) Zn_clus PF00172.13 EDK41795.2 - 1.2e-05 25.1 13.4 2e-05 24.4 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 EDK41795.2 - 0.0097 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold ABC2_membrane PF01061.19 EDK41796.2 - 1.5e-25 89.6 33.6 2e-25 89.1 23.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 EDK41796.2 - 3.9e-23 82.2 0.2 6.7e-23 81.5 0.1 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 EDK41796.2 - 8.2e-10 39.1 1.0 0.00031 20.7 0.0 3.1 3 1 0 4 4 3 2 AAA domain AAA_25 PF13481.1 EDK41796.2 - 9e-05 21.9 0.4 0.017 14.5 0.3 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 EDK41796.2 - 0.00012 22.1 0.2 0.00022 21.2 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 EDK41796.2 - 0.00015 21.8 1.2 0.0022 18.1 0.8 2.2 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 EDK41796.2 - 0.00053 19.1 0.0 0.096 11.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 EDK41796.2 - 0.00056 19.2 0.2 0.0014 17.9 0.1 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 EDK41796.2 - 0.0012 19.7 0.0 0.0031 18.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain SbcCD_C PF13558.1 EDK41796.2 - 0.0026 17.6 0.0 0.0084 16.0 0.0 2.0 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.1 EDK41796.2 - 0.004 17.4 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 EDK41796.2 - 0.0088 16.2 0.1 0.04 14.1 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 EDK41796.2 - 0.0096 15.7 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 EDK41796.2 - 0.014 14.8 1.8 0.031 13.7 1.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.14 EDK41796.2 - 0.015 14.7 0.1 0.029 13.8 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 EDK41796.2 - 0.021 14.8 0.2 0.047 13.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 EDK41796.2 - 0.023 13.8 0.1 0.041 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 EDK41796.2 - 0.028 14.1 0.1 0.13 12.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PDR_assoc PF08370.6 EDK41796.2 - 0.03 13.8 0.2 0.03 13.8 0.1 2.3 2 0 0 2 2 1 0 Plant PDR ABC transporter associated AAA_19 PF13245.1 EDK41796.2 - 0.072 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 EDK41796.2 - 0.093 13.0 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 EDK41796.2 - 0.14 11.8 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PAP2 PF01569.16 EDK41797.2 - 5.2e-12 45.5 7.2 5.2e-12 45.5 5.0 2.3 3 0 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.1 EDK41797.2 - 0.043 13.3 11.9 0.09 12.2 8.2 1.5 1 0 0 1 1 1 0 PAP2 superfamily LicD PF04991.8 EDK41798.2 - 8e-42 143.6 0.5 8e-42 143.6 0.4 2.7 3 0 0 3 3 3 1 LicD family Aldo_ket_red PF00248.16 EDK41799.2 - 9.4e-52 175.5 0.0 1.1e-51 175.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 EDK41800.2 - 1.7e-50 171.4 0.0 2.1e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.11 EDK41801.2 - 5.6e-27 94.3 15.0 5.6e-27 94.3 10.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UPF0546 PF10639.4 EDK41801.2 - 0.048 13.4 4.8 0.28 11.0 0.2 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0546 Transp_cyt_pur PF02133.10 EDK41802.2 - 2.1e-70 237.4 39.5 2.7e-70 237.1 27.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ATP_synth_reg PF14960.1 EDK41802.2 - 0.054 12.6 0.1 0.19 10.9 0.1 1.9 1 0 0 1 1 1 0 ATP synthase regulation RAI1 PF08652.6 EDK41803.2 - 0.0059 16.3 0.0 0.032 14.0 0.0 2.3 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease RAI1 PF08652.6 EDK41805.2 - 0.00025 20.7 1.4 0.0071 16.1 0.0 2.9 1 1 1 2 2 2 1 RAI1 like PD-(D/E)XK nuclease Peptidase_S8 PF00082.17 EDK41807.2 - 4.1e-43 147.5 6.0 5.6e-43 147.1 4.1 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 EDK41807.2 - 1.2e-11 45.0 0.0 2.5e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Hyphal_reg_CWP PF11765.3 EDK41808.2 - 1.3e-109 366.0 19.2 3.2e-109 364.7 13.3 1.7 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal Flocculin_t3 PF13928.1 EDK41808.2 - 9.7e-14 51.2 19.8 9.7e-14 51.2 13.7 13.4 7 3 2 9 9 9 1 Flocculin type 3 repeat Cro PF09048.5 EDK41808.2 - 0.092 12.3 14.9 1.6e+02 2.0 0.0 7.9 8 0 0 8 8 8 0 Cro NPV_P10 PF05531.7 EDK41809.2 - 0.019 15.1 1.4 0.019 15.1 1.0 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AAA_5 PF07728.9 EDK41809.2 - 0.029 14.0 0.0 0.029 14.0 0.0 1.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Caps_synth_GfcC PF06251.6 EDK41809.2 - 0.031 13.4 0.7 0.06 12.5 0.5 1.4 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Laminin_II PF06009.7 EDK41809.2 - 0.17 11.6 5.7 0.33 10.6 1.6 2.4 2 0 0 2 2 2 0 Laminin Domain II DUF607 PF04678.8 EDK41809.2 - 0.62 9.9 4.0 0.59 10.0 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function, DUF607 YtxH PF12732.2 EDK41809.2 - 0.62 10.4 8.1 2.8 8.3 5.6 2.3 1 1 0 1 1 1 0 YtxH-like protein DUF1664 PF07889.7 EDK41809.2 - 1.3 8.8 5.8 0.41 10.4 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Herpes_UL6 PF01763.11 EDK41809.2 - 1.7 6.7 11.0 0.069 11.3 2.8 1.9 2 1 0 2 2 2 0 Herpesvirus UL6 like Syntaxin PF00804.20 EDK41809.2 - 1.8 8.8 10.6 0.14 12.3 3.4 2.2 2 1 0 2 2 2 0 Syntaxin Laminin_I PF06008.9 EDK41809.2 - 3.9 6.7 14.4 0.15 11.3 5.0 2.2 3 0 0 3 3 3 0 Laminin Domain I F-box PF00646.28 EDK41811.2 - 0.067 12.8 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 F-box domain LRR_4 PF12799.2 EDK41812.2 - 2.2e-09 36.6 16.9 0.21 11.2 0.6 9.3 5 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK41812.2 - 5.3e-06 26.0 16.8 0.032 14.0 1.3 7.2 5 1 4 9 9 9 3 Leucine rich repeat LRR_1 PF00560.28 EDK41812.2 - 1.9e-05 24.0 14.7 21 5.6 0.6 10.1 6 3 1 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 EDK41812.2 - 0.00014 21.4 12.4 30 5.4 0.0 9.3 10 1 1 11 11 11 0 Leucine rich repeat FNIP PF05725.7 EDK41812.2 - 0.00075 19.3 14.0 0.24 11.3 0.0 5.8 6 2 1 7 7 7 3 FNIP Repeat LRR_6 PF13516.1 EDK41812.2 - 0.43 10.8 15.3 17 5.8 0.0 8.6 10 2 2 12 12 12 0 Leucine Rich repeat MFS_1 PF07690.11 EDK41813.2 - 1.3e-35 122.7 38.6 1.3e-35 122.7 26.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 EDK41813.2 - 2.7e-09 35.7 2.7 2.7e-09 35.7 1.9 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 EDK41813.2 - 0.02 12.9 10.2 0.025 12.6 1.2 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF1049 PF06305.6 EDK41813.2 - 4 7.0 13.5 1.4 8.4 0.1 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1049) PRANC PF09372.5 EDK41814.2 - 0.077 12.9 2.3 0.14 12.1 0.1 2.5 2 1 1 3 3 3 0 PRANC domain LRR_4 PF12799.2 EDK41815.2 - 1.6e-12 46.7 39.3 0.00073 19.1 0.9 9.4 4 4 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 EDK41815.2 - 5.5e-09 34.8 37.3 0.51 10.5 0.0 11.2 9 3 2 11 11 11 5 Leucine Rich Repeat LRR_8 PF13855.1 EDK41815.2 - 6.2e-09 35.4 35.4 0.0067 16.1 2.3 7.0 3 3 3 6 6 6 6 Leucine rich repeat LRR_7 PF13504.1 EDK41815.2 - 5.4e-07 28.7 34.2 1.8 9.0 0.0 12.7 12 2 2 14 14 14 2 Leucine rich repeat LRR_6 PF13516.1 EDK41815.2 - 0.00098 18.9 31.6 16 5.9 0.1 11.3 12 0 0 12 12 12 1 Leucine Rich repeat DUF2424 PF10340.4 EDK41816.2 - 1e-28 100.0 0.0 1.5e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 EDK41816.2 - 3.2e-18 66.0 0.0 4.7e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 EDK41816.2 - 0.002 17.8 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 EDK41816.2 - 0.04 13.7 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family LRR_4 PF12799.2 EDK41817.2 - 0.00017 21.1 36.8 0.65 9.6 2.3 10.3 6 2 4 10 10 10 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 EDK41817.2 - 0.0038 16.9 30.2 0.21 11.3 1.6 7.8 3 1 5 9 9 9 5 Leucine rich repeat LRR_1 PF00560.28 EDK41817.2 - 0.014 15.3 32.2 5.5 7.4 0.1 11.6 10 4 3 13 13 13 0 Leucine Rich Repeat LRR_7 PF13504.1 EDK41817.2 - 0.058 13.6 30.2 16 6.2 0.0 12.5 13 1 0 13 13 13 0 Leucine rich repeat COX1 PF00115.15 EDK41818.2 - 2.3e-07 29.7 4.1 2.9e-07 29.5 2.9 1.2 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I LAGLIDADG_1 PF00961.14 EDK41818.2 - 0.005 17.3 2.0 0.005 17.3 1.4 2.3 1 1 1 2 2 2 1 LAGLIDADG endonuclease Oxidored_q1 PF00361.15 EDK41819.1 - 1.3e-21 77.0 9.5 1.3e-21 77.0 6.6 3.4 2 1 1 3 3 3 1 NADH-Ubiquinone/plastoquinone (complex I), various chains NADH5_C PF06455.6 EDK41819.1 - 4.8e-13 48.8 9.2 4.8e-13 48.8 6.4 2.8 2 2 0 2 2 2 1 NADH dehydrogenase subunit 5 C-terminus Med6 PF04934.9 EDK41819.1 - 0.016 14.7 0.3 0.032 13.7 0.2 1.4 1 0 0 1 1 1 0 MED6 mediator sub complex component PIG-F PF06699.6 EDK41819.1 - 1.3 8.9 5.3 11 5.9 0.0 2.8 2 1 1 3 3 3 0 GPI biosynthesis protein family Pig-F Oxidored_q1 PF00361.15 EDK41820.1 - 6.4e-16 58.4 8.6 6.4e-16 58.4 6.0 1.6 2 0 0 2 2 2 1 NADH-Ubiquinone/plastoquinone (complex I), various chains DUF4126 PF13548.1 EDK41820.1 - 0.015 14.7 0.3 0.015 14.7 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4126) Cytochrom_B_C PF00032.12 EDK41821.1 - 1.5e-36 124.7 1.5 1.5e-36 124.7 1.0 2.0 2 0 0 2 2 2 1 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N_2 PF13631.1 EDK41821.1 - 2.3e-06 27.4 0.2 2.3e-06 27.4 0.1 2.1 2 1 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB GIY-YIG PF01541.19 EDK41822.1 - 1.8e-05 25.0 4.6 5.2e-05 23.5 3.2 1.9 1 1 0 1 1 1 1 GIY-YIG catalytic domain NUMOD1 PF07453.8 EDK41822.1 - 6.5e-05 22.6 14.3 0.00016 21.3 1.0 3.4 3 0 0 3 3 3 2 NUMOD1 domain NuA4 PF09340.5 EDK41822.1 - 0.074 12.7 0.8 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4