# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Pentapeptide_4 PF13599.6 EDP41363.1 - 0.0016 18.6 0.0 1.5 9.0 0.0 2.7 1 1 0 2 2 2 2 Pentapeptide repeats (9 copies) DUF2924 PF11149.8 EDP41363.1 - 0.18 12.1 8.6 8.2 6.8 0.8 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF2924) Cu-oxidase_2 PF07731.14 EDP41365.1 - 1.3e-38 131.8 3.1 1.9e-38 131.3 3.1 1.3 1 0 0 1 1 1 1 Multicopper oxidase TruB_C_2 PF16198.5 EDP41365.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 tRNA pseudouridylate synthase B C-terminal domain Na_Ca_ex PF01699.24 EDP41366.1 - 9.6e-22 77.6 7.9 1.3e-21 77.1 7.9 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Romo1 PF10247.9 EDP41366.1 - 0.009 16.4 1.7 0.018 15.4 1.7 1.4 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 DUF1661 PF07877.11 EDP41366.1 - 0.21 11.3 0.1 0.52 10.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1661) preSET_CXC PF18264.1 EDP41368.1 - 2.5 8.6 16.6 5.2 7.6 5.9 2.3 2 0 0 2 2 2 0 CXC domain Defensin_2 PF01097.18 EDP41369.1 - 0.00013 21.8 10.5 0.00013 21.8 10.5 2.8 2 1 1 3 3 3 1 Arthropod defensin Defensin_2 PF01097.18 EDP41370.1 - 0.00042 20.2 12.5 0.00042 20.2 12.5 2.8 2 1 1 3 3 3 1 Arthropod defensin FMN_dh PF01070.18 EDP41371.1 - 7.7e-113 377.1 0.0 8.7e-113 376.9 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 EDP41371.1 - 6.4e-06 25.8 0.1 1.1e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDP41371.1 - 0.00022 20.3 1.3 0.00067 18.7 0.5 2.1 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EDP41371.1 - 0.002 17.3 0.2 0.0033 16.6 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EDP41371.1 - 0.0035 16.7 0.2 0.41 9.9 0.2 2.3 1 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EDP41371.1 - 0.011 15.2 0.2 0.14 11.6 0.0 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein SH3_12 PF18129.1 EDP41371.1 - 0.019 15.1 0.2 0.04 14.0 0.2 1.6 1 0 0 1 1 1 0 Xrn1 SH3-like domain Ricin_B_lectin PF00652.22 EDP41372.1 - 0.029 14.6 0.2 0.4 10.9 0.0 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain Asp PF00026.23 EDP41373.1 - 1.6e-30 106.7 0.0 1.9e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP41373.1 - 0.00016 22.3 0.1 0.082 13.6 0.1 2.4 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP41373.1 - 0.00076 20.0 0.0 0.52 10.9 0.1 2.4 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDP41373.1 - 0.0068 16.2 0.0 0.013 15.3 0.0 1.6 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal DUF2730 PF10805.8 EDP41375.1 - 0.022 14.8 0.3 0.027 14.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) TolA_bind_tri PF16331.5 EDP41375.1 - 0.061 13.4 2.1 0.14 12.3 0.2 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation HHH_7 PF14635.6 EDP41375.1 - 0.083 13.2 0.1 0.094 13.1 0.1 1.1 1 0 0 1 1 1 0 Helix-hairpin-helix motif Bap31_Bap29_C PF18035.1 EDP41375.1 - 0.093 12.8 0.4 0.11 12.5 0.4 1.3 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF465 PF04325.13 EDP41375.1 - 0.18 11.9 1.1 2.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) DUF4288 PF14119.6 EDP41377.1 - 0.022 15.1 0.1 0.051 14.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Serine_rich PF08824.10 EDP41377.1 - 0.072 13.1 1.9 1.4 8.9 0.1 2.4 1 1 0 2 2 2 0 Serine rich protein interaction domain Defensin_2 PF01097.18 EDP41378.1 - 0.00042 20.2 12.5 0.00042 20.2 12.5 2.8 2 1 1 3 3 3 1 Arthropod defensin Ricin_B_lectin PF00652.22 EDP41380.1 - 0.029 14.6 0.2 0.4 10.9 0.0 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain Asp PF00026.23 EDP41381.1 - 3.2e-39 135.2 0.0 1.4e-38 133.1 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP41381.1 - 2.3e-06 28.2 0.2 0.12 13.0 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP41381.1 - 3.5e-05 24.3 0.0 0.28 11.8 0.0 2.4 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDP41381.1 - 0.013 15.3 0.0 0.059 13.1 0.0 2.1 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EDP41381.1 - 0.088 13.0 0.0 12 6.1 0.0 2.5 2 1 1 3 3 3 0 Xylanase inhibitor N-terminal Cu-oxidase_2 PF07731.14 EDP41383.1 - 9.7e-45 151.7 4.7 2.6e-37 127.6 0.7 3.3 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 EDP41383.1 - 8.7e-35 120.2 0.6 1.8e-34 119.2 0.1 1.7 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP41383.1 - 8.2e-26 90.4 4.8 9.6e-23 80.5 0.2 4.6 4 2 0 4 4 4 2 Multicopper oxidase Antigen_C PF16364.5 EDP41383.1 - 0.11 12.9 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Cell surface antigen C-terminus Aldo_ket_red PF00248.21 EDP41384.1 - 1.4e-70 237.8 0.1 1.8e-70 237.5 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 EDP41385.1 - 7.7e-16 58.0 45.1 1.5e-15 57.0 41.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EDP41385.1 - 0.059 12.2 26.5 0.88 8.4 24.9 2.2 1 1 0 1 1 1 0 MFS_1 like family Comm PF15957.5 EDP41385.1 - 1.1 9.6 0.0 1.1 9.6 0.0 2.4 3 0 0 3 3 3 0 Commissureless tRNA_synthFbeta PF17759.1 EDP41386.1 - 3e-50 170.6 0.0 3.7e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B5 PF03484.15 EDP41386.1 - 2.1e-14 53.5 0.0 5e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase B5 domain MFS_1 PF07690.16 EDP41388.1 - 3.2e-12 46.1 8.1 4.6e-12 45.5 8.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily 7TM_GPCR_Str PF10326.9 EDP41388.1 - 0.2 11.0 3.7 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str Cu-oxidase_2 PF07731.14 EDP41389.1 - 6.6e-41 139.3 4.4 1.6e-39 134.8 2.7 2.2 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EDP41389.1 - 1.2e-30 106.7 0.9 6.7e-30 104.3 0.2 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP41390.1 - 5.1e-18 65.2 0.0 6.3e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDP41390.1 - 0.02 14.7 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Multicopper oxidase DUF3615 PF12274.8 EDP41390.1 - 0.073 13.6 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) FMN_dh PF01070.18 EDP41391.1 - 1.2e-65 221.9 0.5 1.3e-65 221.7 0.5 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 EDP41391.1 - 1.7e-06 27.7 0.3 2.2e-06 27.3 0.3 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDP41391.1 - 3.7e-05 22.9 2.2 0.00018 20.6 0.3 2.4 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EDP41391.1 - 0.00043 19.7 0.3 0.11 11.8 0.2 2.1 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 EDP41391.1 - 0.00054 19.2 0.2 0.00078 18.7 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 EDP41391.1 - 0.0012 18.3 0.2 0.034 13.6 0.0 2.0 1 1 1 2 2 2 1 Histidine biosynthesis protein SH3_12 PF18129.1 EDP41391.1 - 0.004 17.2 0.3 0.0097 16.0 0.2 1.6 1 1 0 1 1 1 1 Xrn1 SH3-like domain DHO_dh PF01180.21 EDP41391.1 - 0.14 11.4 0.2 0.17 11.0 0.2 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase DHDPS PF00701.22 EDP41391.1 - 0.15 10.8 0.1 0.19 10.4 0.1 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Hydrolase_like PF13242.6 EDP41391.1 - 0.17 12.0 0.8 9.6 6.4 0.0 2.4 2 1 0 2 2 2 0 HAD-hyrolase-like Chitin_synth_1 PF01644.17 EDP41393.1 - 1.8e-68 229.6 0.0 2.5e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDP41393.1 - 8.7e-23 80.1 0.0 1.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDP41393.1 - 2.6e-05 23.1 0.0 0.00011 21.0 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase DASH_Ask1 PF08655.10 EDP41394.1 - 1.2e-29 101.9 1.1 2.4e-29 101.0 1.1 1.5 1 0 0 1 1 1 1 DASH complex subunit Ask1 OTU PF02338.19 EDP41395.1 - 3.5e-26 92.2 0.0 6.5e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EDP41395.1 - 0.03 13.8 0.1 0.18 11.2 0.1 2.0 1 1 0 1 1 1 0 Peptidase C65 Otubain Actin PF00022.19 EDP41396.1 - 2.3e-120 401.9 0.0 2.7e-120 401.7 0.0 1.0 1 0 0 1 1 1 1 Actin Phosphoesterase PF04185.14 EDP41397.1 - 1.9e-75 254.3 2.2 3e-75 253.7 2.2 1.3 1 0 0 1 1 1 1 Phosphoesterase family MFS_1 PF07690.16 EDP41398.1 - 5.7e-24 84.7 20.4 1.9e-23 82.9 13.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Transp_cyt_pur PF02133.15 EDP41399.1 - 1.5e-22 80.0 40.9 2.9e-22 79.1 39.9 1.8 1 1 1 2 2 2 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sugar_tr PF00083.24 EDP41400.1 - 8.9e-61 206.1 6.9 1e-60 205.9 6.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter FtsH_ext PF06480.15 EDP41400.1 - 0.3 11.5 0.9 2 8.8 1.1 2.3 2 0 0 2 2 2 0 FtsH Extracellular GARS_A PF01071.19 EDP41401.1 - 3.9e-72 242.1 0.0 5.9e-72 241.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 EDP41401.1 - 1.5e-35 122.6 0.0 3.6e-35 121.4 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 EDP41401.1 - 2e-29 102.2 0.2 8.9e-29 100.1 0.0 2.3 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EDP41401.1 - 1.3e-27 95.9 2.2 4.7e-27 94.1 1.2 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EDP41401.1 - 4.1e-15 56.2 1.4 1.6e-14 54.3 0.8 2.4 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 EDP41401.1 - 0.00051 20.1 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_2 PF08442.10 EDP41401.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.17 EDP41401.1 - 0.064 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain CAF1C_H4-bd PF12265.8 EDP41402.1 - 7.9e-18 64.5 0.1 3.9e-17 62.3 0.0 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EDP41402.1 - 2.4e-14 53.5 15.1 8.9e-06 26.4 0.1 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41402.1 - 0.00056 20.2 0.1 0.2 12.0 0.1 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF3246 PF11596.8 EDP41402.1 - 0.0053 16.2 0.9 0.0053 16.2 0.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3246) Ricin_B_lectin PF00652.22 EDP41403.1 - 0.027 14.7 0.0 0.14 12.4 0.0 2.0 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain Asp PF00026.23 EDP41404.1 - 1.3e-16 60.9 0.3 1.8e-11 44.0 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP41404.1 - 0.0023 18.5 0.1 2.8 8.7 0.0 2.8 3 0 0 3 3 3 2 Aspartyl protease SepSecS PF05889.13 EDP41404.1 - 0.0036 16.0 0.0 0.005 15.6 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS S1FA PF04689.13 EDP41406.1 - 0.12 12.6 2.3 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 DNA binding protein S1FA SRTM1 PF15872.5 EDP41406.1 - 0.27 11.4 1.5 0.34 11.1 0.2 1.8 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 DUF3742 PF12553.8 EDP41406.1 - 0.49 10.5 3.5 0.28 11.3 1.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3742) DUF2208 PF09973.9 EDP41406.1 - 3 7.4 5.3 0.26 10.9 0.5 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) VirB3 PF05101.13 EDP41406.1 - 5.4 7.3 19.9 0.76 10.0 9.7 2.6 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein Defensin_2 PF01097.18 EDP41407.1 - 0.0053 16.7 10.2 0.0053 16.7 10.2 3.1 2 1 1 3 3 3 1 Arthropod defensin MFS_1 PF07690.16 EDP41409.1 - 4.1e-07 29.3 29.3 1.8e-06 27.1 2.5 2.7 3 1 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EDP41409.1 - 1.5e-05 23.8 11.7 0.00026 19.7 3.7 3.2 2 1 0 2 2 2 2 MFS/sugar transport protein GTP_EFTU PF00009.27 EDP41410.1 - 3.3e-44 150.8 0.0 4.9e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EDP41410.1 - 5.2e-36 123.9 5.7 8.2e-36 123.3 5.7 1.3 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EDP41410.1 - 4.8e-24 84.5 0.0 9.8e-24 83.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EDP41410.1 - 6.8e-22 77.3 0.0 2e-21 75.8 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDP41410.1 - 9.9e-08 32.3 0.0 2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP41410.1 - 3.9e-07 30.1 0.1 9.2e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase EFG_II PF14492.6 EDP41410.1 - 2.7e-05 24.2 0.0 5.7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Roc PF08477.13 EDP41410.1 - 0.0083 16.3 0.0 0.054 13.7 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EDP41410.1 - 0.018 15.1 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Ras PF00071.22 EDP41410.1 - 0.048 13.2 0.0 0.21 11.1 0.0 1.9 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 EDP41410.1 - 0.097 12.1 0.1 0.36 10.3 0.1 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 EDP41411.1 - 1.2e-14 54.9 0.0 2.1e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDP41411.1 - 4e-06 26.7 0.0 8.1e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EDP41411.1 - 5.1e-05 23.3 0.0 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_2 PF07724.14 EDP41411.1 - 5.4e-05 23.4 0.0 9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDP41411.1 - 0.00012 22.3 0.0 0.003 17.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDP41411.1 - 0.00012 22.5 0.2 0.0019 18.6 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EDP41411.1 - 0.00071 19.7 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDP41411.1 - 0.00087 19.3 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDP41411.1 - 0.00095 18.8 0.2 1.1 8.8 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.6 EDP41411.1 - 0.0015 18.5 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDP41411.1 - 0.0023 18.2 0.0 0.11 12.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP41411.1 - 0.011 15.5 0.1 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDP41411.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EDP41411.1 - 0.029 14.3 0.1 0.15 11.9 0.0 1.9 1 1 1 2 2 2 0 NTPase NACHT PF05729.12 EDP41411.1 - 0.034 14.1 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_assoc_2 PF16193.5 EDP41411.1 - 0.036 14.4 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain AAA_17 PF13207.6 EDP41411.1 - 0.04 14.3 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDP41411.1 - 0.091 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EDP41411.1 - 0.2 11.7 0.0 0.45 10.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EDP41411.1 - 0.21 12.2 0.0 0.41 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDP41411.1 - 0.22 10.6 0.0 0.38 9.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 EDP41411.1 - 0.24 10.7 0.0 0.47 9.8 0.0 1.4 1 0 0 1 1 1 0 KaiC Exo_endo_phos PF03372.23 EDP41412.1 - 4.5e-11 42.7 0.1 7.1e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Brr6_like_C_C PF10104.9 EDP41412.1 - 0.0087 15.8 0.1 0.014 15.2 0.1 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Pyridoxal_deC PF00282.19 EDP41413.1 - 1.2e-59 201.9 0.0 1.8e-59 201.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDP41413.1 - 0.0013 17.7 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Ribosomal_60s PF00428.19 EDP41414.1 - 2.3e-23 82.6 10.2 6.2e-23 81.2 9.2 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.20 EDP41414.1 - 2.4e-23 82.1 0.8 7.3e-23 80.6 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EDP41414.1 - 8.5e-20 70.5 0.0 1.5e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P ECH_1 PF00378.20 EDP41416.1 - 7.4e-21 74.6 0.1 9.7e-21 74.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDP41416.1 - 3.6e-06 26.7 0.1 4.9e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Arc PF03869.14 EDP41416.1 - 0.0031 17.3 0.0 0.081 12.8 0.0 2.9 3 0 0 3 3 3 1 Arc-like DNA binding domain Peptidase_S49 PF01343.18 EDP41416.1 - 0.032 14.2 0.1 0.6 10.1 0.1 2.1 2 0 0 2 2 2 0 Peptidase family S49 ECH_1 PF00378.20 EDP41417.1 - 2.3e-17 63.2 0.0 3e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDP41417.1 - 0.0016 18.0 0.0 0.0021 17.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4269 PF14091.6 EDP41417.1 - 0.095 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) WD40 PF00400.32 EDP41418.1 - 9.9e-06 26.2 3.1 1 10.3 0.2 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41418.1 - 0.00051 20.3 0.0 0.14 12.5 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SAS4 PF15460.6 EDP41419.1 - 2.6e-05 24.3 3.0 5.9e-05 23.1 3.0 1.7 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 PEHE PF15275.6 EDP41419.1 - 0.00091 19.9 1.5 0.00091 19.9 1.5 2.3 1 1 0 2 2 2 1 PEHE domain CHORD PF04968.12 EDP41420.1 - 7.3e-46 154.7 14.9 1e-23 83.8 1.5 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 EDP41420.1 - 0.00024 22.1 0.3 0.00049 21.1 0.0 1.7 2 0 0 2 2 2 1 CS domain FAP PF07174.11 EDP41420.1 - 0.0011 18.5 7.9 0.0018 17.8 7.9 1.3 1 0 0 1 1 1 1 Fibronectin-attachment protein (FAP) BTK PF00779.19 EDP41420.1 - 0.12 12.3 11.4 0.19 11.5 3.1 3.3 3 1 0 3 3 3 0 BTK motif ADH_zinc_N PF00107.26 EDP41423.1 - 4.4e-09 36.4 0.0 7.4e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP41423.1 - 8.2e-05 22.4 0.1 0.00035 20.4 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N PF08240.12 EDP41424.1 - 0.0002 21.2 0.4 0.0031 17.4 0.0 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDP41424.1 - 0.0023 17.9 0.0 0.0055 16.7 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EDP41425.1 - 4.9e-10 39.5 0.0 9.9e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP41425.1 - 0.00091 19.1 0.0 0.0034 17.2 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain TolA_bind_tri PF16331.5 EDP41426.1 - 0.061 13.4 2.2 0.13 12.3 0.3 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation HHH_7 PF14635.6 EDP41426.1 - 0.1 13.0 0.1 0.11 12.8 0.1 1.1 1 0 0 1 1 1 0 Helix-hairpin-helix motif BST2 PF16716.5 EDP41426.1 - 0.1 13.2 0.2 0.12 12.9 0.2 1.3 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 DUF465 PF04325.13 EDP41426.1 - 0.18 11.9 1.1 2.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Transp_cyt_pur PF02133.15 EDP41427.1 - 5.5e-30 104.5 32.8 8.6e-30 103.9 32.8 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF3040 PF11239.8 EDP41427.1 - 1.2 9.4 0.0 1.2 9.4 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) Glyco_hydro_43 PF04616.14 EDP41428.1 - 3.8e-35 121.6 0.0 4.3e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 ADH_zinc_N PF00107.26 EDP41429.1 - 3.5e-23 82.0 0.0 7.6e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP41429.1 - 7.5e-11 43.2 0.0 2.2e-10 41.7 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP41429.1 - 3.7e-10 39.7 0.1 1.6e-09 37.6 0.0 2.0 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain HupF_HypC PF01455.18 EDP41429.1 - 0.022 14.9 0.3 0.65 10.2 0.0 2.4 1 1 1 2 2 2 0 HupF/HypC family AA_kinase PF00696.28 EDP41430.1 - 2.3e-32 112.5 0.0 4e-32 111.7 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 EDP41430.1 - 2.3e-08 33.7 1.9 0.0015 18.3 0.1 3.0 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 EDP41430.1 - 1e-07 31.7 1.5 0.00053 19.7 0.1 2.5 2 0 0 2 2 2 2 ACT domain Cse1 PF08506.10 EDP41431.1 - 4.3e-132 440.4 0.2 7.2e-132 439.7 0.2 1.4 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EDP41431.1 - 3.7e-121 404.7 0.0 7.6e-121 403.7 0.0 1.5 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EDP41431.1 - 9.8e-16 57.4 1.6 3.2e-13 49.4 0.1 3.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EDP41431.1 - 0.00033 20.7 0.5 0.00033 20.7 0.5 4.4 5 3 0 5 5 5 1 Exportin 1-like protein UTP15_C PF09384.10 EDP41431.1 - 0.094 12.4 0.3 1.6 8.4 0.0 2.5 1 1 1 2 2 2 0 UTP15 C terminal Cullin_binding PF03556.15 EDP41431.1 - 0.11 12.9 0.0 0.46 10.9 0.0 2.1 1 0 0 1 1 1 0 Cullin binding RNB PF00773.19 EDP41432.1 - 8e-51 173.3 0.0 1.2e-50 172.7 0.0 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EDP41432.1 - 1.9e-19 69.5 0.0 3.6e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EDP41432.1 - 1.1e-14 54.5 0.0 2.3e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EDP41432.1 - 0.00016 21.8 0.0 0.55 10.4 0.0 3.3 3 0 0 3 3 3 2 Cold shock domain Rrp44_CSD1 PF17216.3 EDP41432.1 - 0.00048 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Prot_ATP_ID_OB PF16450.5 EDP41432.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain OB_RNB PF08206.11 EDP41432.1 - 0.071 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain NIF PF03031.18 EDP41433.1 - 1.9e-09 37.5 0.1 0.0019 18.0 0.1 2.1 1 1 0 2 2 2 2 NLI interacting factor-like phosphatase ACOX PF01756.19 EDP41434.1 - 1.8e-38 131.9 0.0 3e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EDP41434.1 - 7.7e-22 77.3 0.0 1.4e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 EDP41434.1 - 3.8e-11 43.6 0.0 8.5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 EDP41434.1 - 3.4e-09 37.1 0.1 1e-08 35.5 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Mito_carr PF00153.27 EDP41435.1 - 2.1e-48 162.2 4.9 3.9e-22 78.0 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EDP41435.1 - 0.00019 21.8 0.3 0.00048 20.5 0.3 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EDP41435.1 - 0.00025 20.7 0.1 0.0015 18.3 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EDP41435.1 - 0.0011 18.4 0.1 0.011 15.3 0.0 2.4 2 0 0 2 2 2 1 EF hand Tubulin PF00091.25 EDP41436.1 - 6.9e-67 225.5 0.0 9.5e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDP41436.1 - 9e-49 164.8 0.0 1.4e-48 164.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EDP41436.1 - 0.00046 19.9 0.0 0.0011 18.7 0.0 1.8 1 1 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDP41436.1 - 0.093 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Tubulin like SRF-TF PF00319.18 EDP41437.1 - 5.2e-20 70.7 0.0 8.2e-20 70.0 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) zf-U1 PF06220.12 EDP41438.1 - 1.6e-07 31.0 0.9 2.8e-07 30.2 0.9 1.4 1 0 0 1 1 1 1 U1 zinc finger MqsA_antitoxin PF15731.5 EDP41438.1 - 0.028 14.5 0.2 0.055 13.6 0.2 1.4 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA CPSF_A PF03178.15 EDP41439.1 - 9.3e-65 219.0 0.0 1.5e-64 218.3 0.0 1.3 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 EDP41439.1 - 1.2e-07 30.8 0.0 2.6e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ribosomal_S26e PF01283.19 EDP41440.1 - 1.2e-19 70.7 0.4 1.3e-19 70.6 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e DUF4333 PF14230.6 EDP41442.1 - 0.073 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4333) Glyco_hydro_16 PF00722.21 EDP41443.1 - 4.7e-22 78.3 0.1 9.3e-22 77.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKG6 PF08693.10 EDP41443.1 - 0.079 12.4 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain bZIP_1 PF00170.21 EDP41444.1 - 0.03 14.4 0.4 0.03 14.4 0.4 2.4 2 0 0 2 2 2 0 bZIP transcription factor YABBY PF04690.13 EDP41444.1 - 0.28 11.7 5.2 0.18 12.4 2.6 2.0 2 0 0 2 2 2 0 YABBY protein bZIP_Maf PF03131.17 EDP41444.1 - 0.44 11.1 12.0 0.74 10.4 11.2 1.8 1 1 0 1 1 1 0 bZIP Maf transcription factor DDHD PF02862.17 EDP41445.1 - 4.9e-11 43.2 0.0 3.3e-09 37.2 0.0 2.9 1 1 0 1 1 1 1 DDHD domain Abhydrolase_6 PF12697.7 EDP41445.1 - 0.018 15.6 0.1 0.018 15.6 0.1 2.9 2 1 1 3 3 3 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EDP41445.1 - 0.12 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase N-SET PF11764.8 EDP41446.1 - 2.2e-06 27.9 4.0 2.2e-06 27.9 4.0 3.2 2 1 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 EDP41446.1 - 4.4e-05 23.9 0.1 0.00074 19.9 0.0 2.8 3 1 0 3 3 3 1 SET domain SET_assoc PF11767.8 EDP41446.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Carboxyl_trans PF01039.22 EDP41447.1 - 3.5e-48 164.5 0.0 4.2e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain FANC_SAP PF18081.1 EDP41447.1 - 4.2 7.6 6.6 21 5.4 0.6 2.5 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain DEAD PF00270.29 EDP41448.1 - 2.8e-42 144.5 0.0 4.3e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP41448.1 - 1.4e-25 89.8 0.0 2.4e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP41448.1 - 0.00011 22.2 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_L27A PF00828.19 EDP41449.1 - 4.3e-36 124.4 0.0 5.7e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Syntaxin PF00804.25 EDP41450.1 - 5.1e-31 107.9 9.1 5.1e-31 107.9 9.1 2.1 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EDP41450.1 - 4.7e-09 36.1 1.1 4.7e-09 36.1 1.1 2.3 2 0 0 2 2 2 1 SNARE domain PBP_N PF17093.5 EDP41450.1 - 0.014 15.7 1.9 0.083 13.1 0.3 2.7 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus DUF4094 PF13334.6 EDP41450.1 - 0.092 13.2 0.2 0.092 13.2 0.2 3.5 3 2 1 4 4 4 0 Domain of unknown function (DUF4094) Laminin_II PF06009.12 EDP41450.1 - 0.12 12.4 8.4 1.1 9.2 1.7 2.6 2 0 0 2 2 2 0 Laminin Domain II PBP1_TM PF14812.6 EDP41450.1 - 1.8 9.0 10.0 1.1 9.6 0.1 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Alg14 PF08660.11 EDP41451.1 - 9.1e-30 103.9 0.0 1.1e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like PDH PF02153.17 EDP41452.1 - 6.5e-12 45.0 0.0 1.1e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EDP41452.1 - 9.8e-05 22.9 0.0 0.00031 21.3 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EDP41452.1 - 0.0039 17.4 0.0 0.0069 16.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EDP41452.1 - 0.033 13.6 0.0 0.067 12.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDP41452.1 - 0.046 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF3410 PF11890.8 EDP41452.1 - 0.13 12.0 0.3 0.36 10.7 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) DAHP_synth_1 PF00793.20 EDP41453.1 - 1.7e-92 309.2 0.0 2.1e-92 308.9 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family TPP_enzyme_N PF02776.18 EDP41454.1 - 2.7e-20 72.7 0.0 4.7e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDP41454.1 - 1.6e-19 70.0 0.0 8.7e-19 67.6 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDP41454.1 - 6.5e-16 58.5 0.0 1.2e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EDP41454.1 - 0.003 16.8 0.1 0.0051 16.1 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase 3Beta_HSD PF01073.19 EDP41455.1 - 5.5e-16 58.4 0.0 7.7e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP41455.1 - 4.8e-15 55.7 0.0 1.1e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP41455.1 - 5.2e-15 55.8 0.1 1.1e-14 54.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDP41455.1 - 8.9e-15 54.5 0.1 2.8e-09 36.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EDP41455.1 - 4.2e-11 42.9 0.0 5.3e-10 39.3 0.0 2.1 1 1 1 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EDP41455.1 - 9.2e-10 38.1 0.0 1.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EDP41455.1 - 2.1e-09 37.2 0.3 4.2e-09 36.3 0.1 1.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDP41455.1 - 7.2e-05 22.3 0.0 0.00041 19.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDP41455.1 - 0.001 19.0 0.4 0.012 15.6 0.1 2.5 2 1 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EDP41455.1 - 0.0086 16.3 0.1 0.032 14.5 0.1 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EDP41455.1 - 0.013 14.6 0.0 0.25 10.4 0.0 2.2 2 1 0 2 2 2 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 EDP41455.1 - 0.044 13.9 0.0 11 6.1 0.0 2.5 2 1 1 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 EDP41456.1 - 7e-13 48.7 0.0 8.7e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP41456.1 - 1.3e-07 32.7 0.0 1.8e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDP41456.1 - 0.0048 16.4 0.0 0.015 14.8 0.0 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus FAD_binding_3 PF01494.19 EDP41457.1 - 7.2e-64 216.2 0.0 9.2e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDP41457.1 - 0.00055 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain p450 PF00067.22 EDP41458.1 - 1.2e-30 106.7 0.3 1.7e-29 102.9 0.3 1.9 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EDP41459.1 - 7.8e-42 143.5 60.8 4.7e-39 134.3 60.6 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDP41459.1 - 0.51 8.6 16.0 0.026 12.8 3.7 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family EIIBC-GUT_C PF07663.11 EDP41459.1 - 1.3 9.3 12.9 0.1 12.8 0.4 3.5 4 0 0 4 4 4 0 Sorbitol phosphotransferase enzyme II C-terminus TPP_enzyme_N PF02776.18 EDP41460.1 - 2.7e-20 72.7 0.0 4.7e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDP41460.1 - 1.6e-19 70.0 0.0 8.7e-19 67.6 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDP41460.1 - 6.5e-16 58.5 0.0 1.2e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EDP41460.1 - 0.003 16.8 0.1 0.0051 16.1 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase 3Beta_HSD PF01073.19 EDP41461.1 - 5.5e-16 58.4 0.0 7.7e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP41461.1 - 4.8e-15 55.7 0.0 1.1e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP41461.1 - 5.2e-15 55.8 0.1 1.1e-14 54.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDP41461.1 - 8.9e-15 54.5 0.1 2.8e-09 36.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EDP41461.1 - 4.2e-11 42.9 0.0 5.3e-10 39.3 0.0 2.1 1 1 1 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EDP41461.1 - 9.2e-10 38.1 0.0 1.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EDP41461.1 - 2.1e-09 37.2 0.3 4.2e-09 36.3 0.1 1.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDP41461.1 - 7.2e-05 22.3 0.0 0.00041 19.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDP41461.1 - 0.001 19.0 0.4 0.012 15.6 0.1 2.5 2 1 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EDP41461.1 - 0.0086 16.3 0.1 0.032 14.5 0.1 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EDP41461.1 - 0.013 14.6 0.0 0.25 10.4 0.0 2.2 2 1 0 2 2 2 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 EDP41461.1 - 0.044 13.9 0.0 11 6.1 0.0 2.5 2 1 1 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 EDP41462.1 - 7e-13 48.7 0.0 8.7e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP41462.1 - 1.3e-07 32.7 0.0 1.8e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDP41462.1 - 0.0048 16.4 0.0 0.015 14.8 0.0 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus FAD_binding_3 PF01494.19 EDP41463.1 - 7.2e-64 216.2 0.0 9.2e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDP41463.1 - 0.00055 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain p450 PF00067.22 EDP41464.1 - 1.2e-30 106.7 0.3 1.7e-29 102.9 0.3 1.9 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EDP41465.1 - 7.8e-42 143.5 60.8 4.7e-39 134.3 60.6 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDP41465.1 - 0.51 8.6 16.0 0.026 12.8 3.7 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family EIIBC-GUT_C PF07663.11 EDP41465.1 - 1.3 9.3 12.9 0.1 12.8 0.4 3.5 4 0 0 4 4 4 0 Sorbitol phosphotransferase enzyme II C-terminus TPP_enzyme_N PF02776.18 EDP41466.1 - 2.7e-20 72.7 0.0 4.7e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDP41466.1 - 1.6e-19 70.0 0.0 8.7e-19 67.6 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDP41466.1 - 6.5e-16 58.5 0.0 1.2e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EDP41466.1 - 0.003 16.8 0.1 0.0051 16.1 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase 3Beta_HSD PF01073.19 EDP41467.1 - 5.5e-16 58.4 0.0 7.7e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP41467.1 - 4.8e-15 55.7 0.0 1.1e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP41467.1 - 5.2e-15 55.8 0.1 1.1e-14 54.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EDP41467.1 - 8.9e-15 54.5 0.1 2.8e-09 36.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EDP41467.1 - 4.2e-11 42.9 0.0 5.3e-10 39.3 0.0 2.1 1 1 1 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EDP41467.1 - 9.2e-10 38.1 0.0 1.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EDP41467.1 - 2.1e-09 37.2 0.3 4.2e-09 36.3 0.1 1.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDP41467.1 - 7.2e-05 22.3 0.0 0.00041 19.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDP41467.1 - 0.001 19.0 0.4 0.012 15.6 0.1 2.5 2 1 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EDP41467.1 - 0.0086 16.3 0.1 0.032 14.5 0.1 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EDP41467.1 - 0.013 14.6 0.0 0.25 10.4 0.0 2.2 2 1 0 2 2 2 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 EDP41467.1 - 0.044 13.9 0.0 11 6.1 0.0 2.5 2 1 1 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 EDP41468.1 - 2.4e-07 30.8 0.0 3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP41468.1 - 3.7e-07 31.3 0.0 5.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDP41468.1 - 0.00085 18.9 0.0 0.046 13.2 0.0 2.6 1 1 1 2 2 2 1 Glucose dehydrogenase C-terminus MOZART1 PF12554.8 EDP41468.1 - 0.15 11.8 0.0 0.53 10.1 0.0 1.9 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated FAD_binding_3 PF01494.19 EDP41469.1 - 7.2e-64 216.2 0.0 9.2e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EDP41469.1 - 0.00055 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain PDH PF02153.17 EDP41470.1 - 4.2e-12 45.6 0.0 6.3e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EDP41470.1 - 1.5e-05 25.5 0.0 5.1e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EDP41470.1 - 0.00014 22.1 0.0 0.00026 21.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EDP41470.1 - 0.00036 20.6 0.0 0.00068 19.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EDP41470.1 - 0.00038 19.9 0.0 0.00074 18.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EDP41470.1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 EDP41470.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Rossmann-like domain TrkA_N PF02254.18 EDP41470.1 - 0.034 14.4 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Herpes_LP PF03363.13 EDP41471.1 - 0.032 14.0 0.2 0.064 13.0 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus leader protein Tim17 PF02466.19 EDP41473.1 - 7.7e-20 71.3 1.1 1.1e-19 70.8 1.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ribosomal_L27 PF01016.19 EDP41474.1 - 1.5e-31 108.2 0.3 3e-31 107.2 0.1 1.5 2 0 0 2 2 2 1 Ribosomal L27 protein ECR1_N PF14382.6 EDP41474.1 - 0.25 11.2 0.2 0.25 11.2 0.2 2.0 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region DUF3835 PF12927.7 EDP41475.1 - 0.16 12.8 0.0 0.16 12.8 0.0 4.5 4 1 0 4 4 4 0 Domain of unknown function (DUF3835) Ccdc124 PF06244.12 EDP41476.1 - 8.5e-27 94.2 1.1 8.5e-27 94.2 1.1 1.9 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF2852 PF11014.8 EDP41476.1 - 0.0022 18.1 3.0 0.0022 18.1 3.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2852) DUF4829 PF16111.5 EDP41476.1 - 0.1 13.4 0.1 0.12 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) DAO PF01266.24 EDP41477.1 - 3.9e-22 79.3 1.5 1.8e-12 47.5 0.8 2.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDP41477.1 - 0.00025 21.2 0.3 0.00061 20.0 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDP41477.1 - 0.00031 20.1 0.2 0.0028 17.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP41477.1 - 0.00094 19.7 0.3 0.0021 18.6 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDP41477.1 - 0.0016 18.9 0.0 0.003 18.0 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EDP41477.1 - 0.0055 15.8 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EDP41477.1 - 0.014 14.7 0.4 0.025 13.9 0.0 1.5 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 EDP41477.1 - 0.015 15.3 0.0 0.042 13.9 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EDP41477.1 - 0.016 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EDP41477.1 - 0.058 12.7 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 EDP41477.1 - 0.061 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glu_dehyd_C PF16912.5 EDP41477.1 - 0.089 12.3 0.1 0.19 11.2 0.0 1.6 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus 3HCDH_N PF02737.18 EDP41477.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C2H2_jaz PF12171.8 EDP41478.1 - 9e-10 38.6 1.1 1.9e-09 37.5 1.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDP41478.1 - 0.00027 21.2 0.5 0.0005 20.4 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDP41478.1 - 0.0021 18.4 1.2 0.0021 18.4 1.2 1.7 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) AAL_decarboxy PF03306.13 EDP41478.1 - 0.07 12.5 0.0 0.077 12.3 0.0 1.1 1 0 0 1 1 1 0 Alpha-acetolactate decarboxylase PBP1_TM PF14812.6 EDP41478.1 - 3.8 8.0 7.4 0.95 9.9 4.1 1.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L35Ae PF01247.18 EDP41479.1 - 1.3e-41 140.6 0.6 1.5e-41 140.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EDP41479.1 - 0.00052 20.2 0.0 1 9.6 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain DNA_pol_B PF00136.21 EDP41480.1 - 2.6e-116 389.1 0.2 4.1e-116 388.4 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EDP41480.1 - 1.6e-46 158.4 0.2 3e-46 157.5 0.2 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EDP41480.1 - 3.2e-23 82.4 0.0 5.8e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EDP41480.1 - 2.8e-06 27.3 5.5 6.2e-06 26.2 5.5 1.6 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EDP41480.1 - 0.064 12.1 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral zinc_ribbon_12 PF11331.8 EDP41480.1 - 0.3 10.9 1.9 0.8 9.6 0.1 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain RED_N PF07808.13 EDP41481.1 - 9.1e-05 22.1 4.1 9.1e-05 22.1 4.1 1.6 2 0 0 2 2 2 1 RED-like protein N-terminal region Colicin_Pyocin PF01320.18 EDP41481.1 - 0.082 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein Phos_pyr_kin PF08543.12 EDP41482.1 - 2e-09 37.2 0.0 4.5e-09 36.1 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EDP41482.1 - 1.1e-06 28.1 0.0 2.6e-05 23.7 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase A_deaminase PF00962.22 EDP41485.1 - 4.4e-118 394.3 0.1 6.2e-118 393.9 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase PGK PF00162.19 EDP41486.1 - 2.8e-148 493.9 2.1 3.1e-148 493.7 2.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF4434 PF14488.6 EDP41486.1 - 0.15 12.1 0.2 6.4 6.8 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) Aldo_ket_red PF00248.21 EDP41487.1 - 6.4e-33 114.2 0.0 1.1e-32 113.5 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Flavoprotein PF02441.19 EDP41488.1 - 1.8e-37 128.5 0.1 2.4e-37 128.1 0.1 1.1 1 0 0 1 1 1 1 Flavoprotein W2 PF02020.18 EDP41489.1 - 2.7e-15 56.3 0.6 2.7e-15 56.3 0.6 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EDP41489.1 - 5.4e-12 44.9 6.7 0.0002 21.0 3.4 4.0 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EDP41489.1 - 1.7e-06 27.3 0.1 2.7e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 EDP41489.1 - 3.1e-06 26.8 1.7 0.013 15.3 0.0 3.3 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 EDP41489.1 - 0.0002 21.7 0.0 0.0004 20.8 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 EDP41489.1 - 0.00065 19.4 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase RNA_pol_3_Rpc31 PF11705.8 EDP41489.1 - 0.97 9.6 11.9 2.9 8.1 11.9 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 LID PF17916.1 EDP41489.1 - 0.98 9.1 6.1 2.7 7.7 6.1 1.7 1 0 0 1 1 1 0 LIM interaction domain (LID) Ran_BP1 PF00638.18 EDP41490.1 - 1.5e-09 38.2 0.4 2.8e-09 37.3 0.4 1.4 1 0 0 1 1 1 1 RanBP1 domain Kei1 PF08552.11 EDP41491.1 - 1.2e-52 178.6 2.1 1.2e-52 178.6 2.1 1.4 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 dsDNA_bind PF01984.20 EDP41492.1 - 2.3e-28 98.7 5.8 2.7e-28 98.4 5.8 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain tRNA_int_endo PF01974.17 EDP41494.1 - 2.7e-17 62.6 0.1 4.6e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EDP41494.1 - 0.0021 17.7 0.1 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Trypan_PARP PF05887.11 EDP41494.1 - 0.06 13.3 0.9 0.13 12.2 0.9 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) mRNA_cap_enzyme PF01331.19 EDP41495.1 - 7.3e-49 166.3 0.0 9.8e-49 165.8 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDP41495.1 - 1.3e-23 83.7 0.1 1.8e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDP41495.1 - 4.9e-05 23.1 0.0 0.005 16.5 0.0 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EDP41495.1 - 0.04 14.2 0.0 0.18 12.1 0.0 2.1 2 0 0 2 2 2 0 RNA ligase 2-Hacid_dh_C PF02826.19 EDP41497.1 - 3.6e-47 160.0 0.0 7.9e-47 158.9 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDP41497.1 - 8.4e-18 64.3 0.0 1.2e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDP41497.1 - 1.7e-06 28.3 0.2 1.2e-05 25.5 0.0 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EDP41497.1 - 0.002 17.7 0.0 0.0042 16.7 0.0 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EDP41497.1 - 0.02 14.2 0.1 0.99 8.7 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_C PF03720.15 EDP41497.1 - 0.053 13.9 0.0 0.45 11.0 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Shikimate_DH PF01488.20 EDP41497.1 - 0.13 12.3 0.1 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DJ-1_PfpI PF01965.24 EDP41499.1 - 9.2e-08 32.1 0.0 2.8e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EDP41499.1 - 0.0016 18.1 0.0 0.0034 17.1 0.0 1.4 1 1 0 1 1 1 1 ThiJ/PfpI family-like Aldo_ket_red PF00248.21 EDP41500.1 - 4.8e-32 111.3 0.0 6e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TfuA PF07812.12 EDP41500.1 - 0.1 12.3 0.0 18 5.1 0.0 2.8 3 0 0 3 3 3 0 TfuA-like protein Cu-oxidase_2 PF07731.14 EDP41501.1 - 6.7e-42 142.5 8.5 7.5e-37 126.1 3.5 3.4 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 EDP41501.1 - 2.5e-34 118.7 0.3 7.9e-34 117.1 0.1 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP41501.1 - 2.5e-24 85.6 6.8 1.4e-21 76.7 0.1 5.0 4 2 0 5 5 5 2 Multicopper oxidase DUF1080 PF06439.11 EDP41501.1 - 0.027 14.6 0.1 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1080) Catalase PF00199.19 EDP41503.1 - 2.8e-175 583.0 0.1 3.5e-175 582.7 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDP41503.1 - 2.5e-19 69.2 0.1 4.9e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EDP41503.1 - 1.1e-12 47.8 0.1 2.3e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain found in long catalases LIP PF03583.14 EDP41504.1 - 7.5e-58 196.1 0.0 9.8e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 EDP41504.1 - 0.0015 18.0 0.6 0.9 9.0 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Cu-oxidase PF00394.22 EDP41505.1 - 3.5e-23 82.5 0.2 5.5e-23 81.8 0.2 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP41505.1 - 1e-22 80.3 3.9 4e-22 78.5 0.2 3.0 2 2 0 2 2 2 1 Multicopper oxidase DUF3615 PF12274.8 EDP41505.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) Cu-oxidase_2 PF07731.14 EDP41506.1 - 1.5e-40 138.1 1.6 2.1e-40 137.6 1.6 1.2 1 0 0 1 1 1 1 Multicopper oxidase Defensin_2 PF01097.18 EDP41508.1 - 0.00042 20.2 12.5 0.00042 20.2 12.5 2.8 2 1 1 3 3 3 1 Arthropod defensin Laminin_I PF06008.14 EDP41509.1 - 0.013 15.2 1.9 1.2 8.8 0.3 2.1 2 0 0 2 2 2 0 Laminin Domain I DUF2730 PF10805.8 EDP41509.1 - 0.023 14.8 0.2 0.045 13.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4288 PF14119.6 EDP41509.1 - 0.04 14.3 0.3 0.086 13.3 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) TolA_bind_tri PF16331.5 EDP41509.1 - 0.18 11.9 0.3 0.18 11.9 0.3 2.7 3 0 0 3 3 3 0 TolA binding protein trimerisation Nup54 PF13874.6 EDP41509.1 - 1.4 9.0 5.8 10 6.2 5.8 2.1 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Catalase PF00199.19 EDP41510.1 - 4.8e-176 585.5 0.1 6.4e-176 585.1 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EDP41510.1 - 5.2e-20 71.4 0.1 9.8e-20 70.5 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EDP41510.1 - 2.1e-10 40.4 0.0 3.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases AbrB_C PF18277.1 EDP41510.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 AbrB C-terminal domain Acetyltransf_2 PF00797.17 EDP41511.1 - 1.4e-61 208.4 0.0 1.7e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 N-acetyltransferase Peptidase_C71 PF12386.8 EDP41511.1 - 0.087 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei DUF676 PF05057.14 EDP41514.1 - 2.6e-06 27.1 0.0 5.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EDP41514.1 - 0.0018 18.0 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 EDP41514.1 - 0.0037 16.6 0.0 0.64 9.2 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDP41514.1 - 0.023 14.8 0.0 0.056 13.5 0.0 1.6 1 0 0 1 1 1 0 Thioesterase domain Palm_thioest PF02089.15 EDP41514.1 - 0.023 14.5 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF915 PF06028.11 EDP41514.1 - 0.044 13.1 0.0 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 EDP41514.1 - 0.066 12.8 0.0 6.8 6.2 0.0 2.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold HGWP PF03578.15 EDP41514.1 - 0.44 10.1 3.1 0.36 10.4 0.6 2.2 2 0 0 2 2 2 0 HGWP repeat Na_Ca_ex PF01699.24 EDP41515.1 - 3.3e-42 144.0 40.5 1.5e-24 86.7 15.1 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Romo1 PF10247.9 EDP41515.1 - 0.053 13.9 5.2 0.29 11.5 2.6 2.8 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Dcc1 PF09724.9 EDP41516.1 - 5.9e-46 157.3 0.0 7.1e-46 157.0 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DUF2116 PF09889.9 EDP41517.1 - 1.1 9.3 2.5 7.8 6.6 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Sld5 PF05916.11 EDP41518.1 - 0.013 15.9 0.0 0.021 15.3 0.0 1.3 1 0 0 1 1 1 0 GINS complex protein HTH_17 PF12728.7 EDP41518.1 - 0.042 14.0 0.0 0.089 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain CAP_GLY PF01302.25 EDP41519.1 - 2.5e-23 81.8 1.8 4.5e-23 81.0 1.8 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EDP41519.1 - 2e-18 66.6 0.0 3.7e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUF1153 PF06627.11 EDP41519.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) ABC_tran_CTD PF16326.5 EDP41520.1 - 0.034 14.4 0.2 0.076 13.3 0.2 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain Med9 PF07544.13 EDP41520.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Pex19 PF04614.12 EDP41520.1 - 0.15 11.8 0.0 0.19 11.5 0.0 1.3 1 1 0 1 1 1 0 Pex19 protein family Pox_A_type_inc PF04508.12 EDP41520.1 - 0.21 11.5 0.4 0.46 10.4 0.4 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Se-cys_synth_N PF12390.8 EDP41520.1 - 1.3 9.4 5.2 3.8 7.8 5.2 1.9 1 1 0 1 1 1 0 Selenocysteine synthase N terminal Uds1 PF15456.6 EDP41521.1 - 2.9e-20 72.7 5.3 2.9e-20 72.7 5.3 11.8 3 1 6 9 9 9 1 Up-regulated During Septation Seryl_tRNA_N PF02403.22 EDP41521.1 - 0.0053 17.0 6.4 0.0053 17.0 6.4 12.7 4 2 9 13 13 13 5 Seryl-tRNA synthetase N-terminal domain HTH_37 PF13744.6 EDP41521.1 - 1.5 8.8 23.2 3.2 7.8 4.3 5.5 2 1 1 3 3 3 0 Helix-turn-helix domain COPIIcoated_ERV PF07970.12 EDP41522.1 - 2.1e-76 256.6 0.1 2.7e-76 256.3 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDP41522.1 - 1.4e-24 86.3 0.0 2.4e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Complex1_49kDa PF00346.19 EDP41523.1 - 1.6e-117 391.4 0.0 2.2e-117 391.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EDP41523.1 - 0.045 12.6 0.0 0.088 11.7 0.0 1.5 1 0 0 1 1 1 0 Nickel-dependent hydrogenase Bromodomain PF00439.25 EDP41524.1 - 2.2e-18 66.1 0.1 5.8e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 Bromodomain PrmA PF06325.13 EDP41525.1 - 0.00019 20.9 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EDP41525.1 - 0.0033 18.1 0.2 0.64 10.8 0.1 3.0 2 1 0 3 3 3 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EDP41525.1 - 0.041 13.5 0.1 0.067 12.8 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 EDP41525.1 - 0.045 13.3 0.0 0.1 12.2 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_23 PF13489.6 EDP41525.1 - 0.056 13.3 0.0 0.1 12.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Syja_N PF02383.18 EDP41525.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 SacI homology domain GNAT_acetyltr_2 PF13718.6 EDP41526.1 - 5e-90 300.9 0.0 8.8e-90 300.1 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EDP41526.1 - 1.3e-64 217.3 0.0 5.6e-64 215.2 0.0 2.0 2 0 0 2 2 2 1 Helicase tRNA_bind_2 PF13725.6 EDP41526.1 - 5.6e-55 186.6 0.1 8.6e-55 186.0 0.1 1.3 1 0 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 EDP41526.1 - 4.4e-30 103.5 0.0 1e-29 102.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 EDP41526.1 - 0.00068 19.9 0.1 0.17 12.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain Acetyltransf_1 PF00583.25 EDP41526.1 - 0.019 15.2 0.0 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDP41526.1 - 0.068 13.6 0.0 0.25 11.8 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sigma70_r4_2 PF08281.12 EDP41526.1 - 0.14 11.9 0.2 0.59 9.9 0.2 2.1 1 0 0 1 1 1 0 Sigma-70, region 4 TAL_FSA PF00923.19 EDP41527.1 - 2.9e-96 322.2 0.3 3.3e-96 322.0 0.3 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase CorA PF01544.18 EDP41528.1 - 9e-11 41.6 3.1 1.4e-10 41.0 3.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein YiaAB PF05360.14 EDP41528.1 - 0.1 12.8 2.4 8.2 6.8 0.2 2.3 2 0 0 2 2 2 0 yiaA/B two helix domain ER PF01133.17 EDP41528.1 - 0.15 12.1 0.2 0.36 10.9 0.2 1.6 1 0 0 1 1 1 0 Enhancer of rudimentary DUF948 PF06103.11 EDP41528.1 - 0.19 12.0 2.1 0.53 10.6 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Adaptin_binding PF10199.9 EDP41529.1 - 0.0081 16.8 0.2 0.042 14.5 0.2 2.0 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 VipB PF05943.12 EDP41529.1 - 0.011 14.6 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion protein, EvpB/VC_A0108, tail sheath Cyclin PF08613.11 EDP41530.1 - 1.1e-08 35.6 0.0 2.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Cyclin RabGAP-TBC PF00566.18 EDP41531.1 - 3.5e-43 147.8 0.0 9.5e-43 146.3 0.0 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Elongin_A PF06881.11 EDP41532.1 - 3.5e-23 82.1 0.0 4.2e-23 81.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A UPF0242 PF06785.11 EDP41534.1 - 6.3 6.9 12.9 12 5.9 9.9 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 EDP41535.1 - 1.3e-28 98.6 19.9 1.1e-07 32.5 0.1 8.0 8 0 0 8 8 8 5 WD domain, G-beta repeat Hira PF07569.11 EDP41535.1 - 9.4e-21 74.6 0.0 2.4e-20 73.3 0.0 1.7 1 1 0 1 1 1 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 EDP41535.1 - 8.1e-11 42.1 0.1 2.8 8.3 0.0 6.5 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EDP41535.1 - 0.0031 17.3 0.6 0.0031 17.3 0.6 1.9 2 0 0 2 2 2 1 HIRA B motif PD40 PF07676.12 EDP41535.1 - 0.037 14.0 0.6 34 4.5 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat HrpE PF06188.12 EDP41535.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E Ge1_WD40 PF16529.5 EDP41535.1 - 0.11 11.4 0.4 4.3 6.2 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4434 PF14488.6 EDP41535.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) adh_short_C2 PF13561.6 EDP41536.1 - 1.4e-57 195.0 0.0 1.9e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDP41536.1 - 2.8e-46 157.4 0.1 3.6e-46 157.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDP41536.1 - 8.6e-13 48.6 0.1 1.2e-12 48.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Pyr_redox_2 PF07992.14 EDP41536.1 - 1.8e-06 27.4 0.0 2.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP41536.1 - 0.0047 17.4 0.0 0.01 16.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 EDP41536.1 - 0.0097 16.1 0.3 0.029 14.6 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.6 EDP41536.1 - 0.012 16.1 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding 3Beta_HSD PF01073.19 EDP41536.1 - 0.031 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EDP41536.1 - 0.077 12.3 0.0 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain HAGH_C PF16123.5 EDP41537.1 - 7.6e-20 71.2 0.0 1.3e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EDP41537.1 - 3.4e-13 50.1 2.4 2e-07 31.3 0.8 2.7 2 1 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EDP41537.1 - 0.00044 19.8 0.1 0.00075 19.1 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF4417 PF14386.6 EDP41537.1 - 0.07 12.7 0.0 9 5.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4417) E3_binding PF02817.17 EDP41537.1 - 0.088 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 e3 binding domain DUF1977 PF09320.11 EDP41538.1 - 2.2e-23 82.5 0.6 3.9e-23 81.7 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EDP41539.1 - 2.2e-05 24.5 0.1 5.9e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 EDP41539.1 - 0.095 12.9 0.3 0.49 10.6 0.2 2.2 1 1 0 1 1 1 0 Tetratricopeptide repeat GerA PF03323.13 EDP41539.1 - 0.2 10.1 0.1 0.23 9.9 0.1 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Mito_carr PF00153.27 EDP41540.1 - 1.2e-63 211.1 2.7 2.8e-22 78.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ChAPs PF09295.10 EDP41541.1 - 3.2e-139 464.3 0.0 4.3e-139 463.9 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 EDP41541.1 - 2.9e-06 27.7 0.2 0.14 12.7 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDP41541.1 - 1.5e-05 24.7 0.5 2.9 8.2 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDP41541.1 - 0.00097 18.4 0.1 0.2 10.8 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP41541.1 - 0.023 15.5 0.4 83 4.4 0.0 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP41541.1 - 0.036 14.3 5.3 2 8.7 0.2 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDP41541.1 - 0.037 14.7 2.0 57 4.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MFS_1 PF07690.16 EDP41542.1 - 1.9e-37 129.0 37.2 1.9e-37 129.0 37.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Myb_DNA-binding PF00249.31 EDP41543.1 - 2.9e-40 136.2 12.2 2.5e-14 53.2 0.9 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP41543.1 - 1e-32 112.2 8.1 5.1e-14 52.3 0.7 3.3 1 1 2 3 3 3 3 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EDP41543.1 - 0.0043 17.2 1.9 0.083 13.1 0.0 3.0 2 1 1 3 3 3 1 SANT/Myb-like domain of DAMP1 SLIDE PF09111.10 EDP41543.1 - 0.0046 17.0 0.0 0.17 11.9 0.0 2.7 2 1 0 2 2 2 1 SLIDE Rap1_C PF11626.8 EDP41543.1 - 0.0078 16.3 0.3 10 6.3 0.5 3.2 2 1 1 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.10 EDP41543.1 - 0.051 13.7 0.1 0.17 12.0 0.1 1.8 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Myb_DNA-bind_7 PF15963.5 EDP41543.1 - 0.069 13.0 0.1 16 5.5 0.0 2.5 2 0 0 2 2 2 0 Myb DNA-binding like Myb_DNA-bind_5 PF13873.6 EDP41543.1 - 0.15 12.1 5.0 1.1 9.3 0.1 3.3 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain FAT PF02259.23 EDP41544.1 - 1.9e-68 231.2 6.7 3.9e-68 230.2 6.7 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EDP41544.1 - 9.7e-24 84.5 0.0 1.7e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TetR_C_16 PF17920.1 EDP41544.1 - 0.013 15.7 1.9 9.4 6.5 0.1 5.0 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain DED PF01335.21 EDP41544.1 - 0.063 13.6 0.7 5.5 7.4 0.1 3.3 2 0 0 2 2 2 0 Death effector domain Sec7_N PF12783.7 EDP41545.1 - 0.36 10.7 17.5 1.6 8.7 0.0 5.3 3 1 2 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PI3_PI4_kinase PF00454.27 EDP41546.1 - 3.8e-30 105.5 0.0 7.9e-29 101.2 0.0 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EDP41546.1 - 0.0042 17.0 0.0 0.0093 15.9 0.0 1.6 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 EDP41546.1 - 0.014 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) MFS_1 PF07690.16 EDP41547.1 - 4.6e-32 111.3 36.0 4.6e-32 111.3 36.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Snf7 PF03357.21 EDP41548.1 - 1.5e-39 135.3 18.1 1.5e-39 135.3 18.1 1.5 1 1 1 2 2 2 1 Snf7 Jnk-SapK_ap_N PF09744.9 EDP41548.1 - 0.41 10.9 13.0 0.068 13.4 7.4 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Atg14 PF10186.9 EDP41548.1 - 0.74 8.8 7.3 1 8.4 7.1 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DAO PF01266.24 EDP41549.1 - 9.5e-47 160.3 1.0 1.2e-46 159.9 1.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDP41549.1 - 0.0026 18.0 0.0 0.0079 16.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDP41549.1 - 0.028 15.0 0.0 0.058 14.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDP41549.1 - 0.045 13.0 0.2 0.16 11.1 0.0 2.0 3 0 0 3 3 3 0 Thi4 family Pyr_redox_2 PF07992.14 EDP41549.1 - 0.076 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 EDP41549.1 - 0.22 10.1 0.0 0.35 9.4 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) BOP1NT PF08145.12 EDP41550.1 - 6.6e-105 350.7 0.8 9.8e-105 350.1 0.8 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EDP41550.1 - 2.8e-19 69.1 0.5 9.6e-06 26.2 0.1 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41550.1 - 0.077 13.3 0.0 30 5.0 0.0 3.1 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Proteasome PF00227.26 EDP41552.1 - 2.3e-25 89.2 0.0 3.3e-25 88.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit DUF515 PF04415.12 EDP41552.1 - 5 5.4 6.1 7.4 4.9 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Kei1 PF08552.11 EDP41552.1 - 5.1 6.9 7.2 8.2 6.3 7.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 TFR_dimer PF04253.15 EDP41553.1 - 3.8e-21 75.4 0.0 1.1e-20 73.9 0.0 1.8 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EDP41553.1 - 4.8e-20 72.1 0.0 8.2e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EDP41553.1 - 2.5e-11 43.4 1.0 5.3e-11 42.4 0.7 1.7 2 0 0 2 2 2 1 PA domain Tmemb_cc2 PF10267.9 EDP41553.1 - 0.028 13.6 0.1 0.32 10.1 0.1 2.0 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Methyltransf_25 PF13649.6 EDP41553.1 - 0.082 13.6 0.1 0.23 12.2 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain SOAR PF16533.5 EDP41553.1 - 0.45 10.5 2.2 4.8 7.2 0.1 2.4 2 0 0 2 2 2 0 STIM1 Orai1-activating region GCN5L1 PF06320.13 EDP41553.1 - 0.74 10.0 2.5 0.56 10.4 0.2 1.9 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF1631 PF07793.11 EDP41553.1 - 2 6.7 5.6 0.34 9.3 1.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1631) WD40 PF00400.32 EDP41554.1 - 1.6e-40 136.3 9.1 1.9e-09 38.0 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41554.1 - 2e-05 24.8 0.3 6.7 7.1 0.1 5.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP41554.1 - 0.0075 15.0 0.3 10 4.6 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 SBDS PF01172.18 EDP41555.1 - 1.2e-16 60.6 0.0 1.4e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein tRNA-synt_2 PF00152.20 EDP41558.1 - 8.3e-85 284.6 0.0 1.2e-84 284.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDP41558.1 - 6.1e-10 39.0 0.0 1.1e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain T2SSE_N PF05157.15 EDP41558.1 - 0.0082 16.4 0.7 0.018 15.3 0.2 1.8 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein E, N-terminal domain cNMP_binding PF00027.29 EDP41559.1 - 8.7e-40 134.7 0.0 2e-19 69.4 0.1 2.5 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 EDP41559.1 - 0.036 13.8 0.0 0.094 12.4 0.0 1.8 1 0 0 1 1 1 0 Cupin domain Mt_ATP-synt_D PF05873.12 EDP41560.1 - 6.4e-06 26.1 0.2 7.4e-06 25.9 0.2 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) HMMR_N PF15905.5 EDP41560.1 - 0.0058 16.2 0.5 0.0068 15.9 0.5 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal XhlA PF10779.9 EDP41560.1 - 0.08 13.2 0.4 0.08 13.2 0.4 1.5 2 0 0 2 2 2 0 Haemolysin XhlA DUF1366 PF07104.11 EDP41560.1 - 0.089 12.5 1.2 0.14 11.8 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1366) Ribosomal_S25 PF03297.15 EDP41561.1 - 5.9e-38 129.1 1.1 1.1e-37 128.3 1.1 1.4 1 0 0 1 1 1 1 S25 ribosomal protein MerR_1 PF13411.6 EDP41561.1 - 0.084 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 MerR HTH family regulatory protein EF-hand_7 PF13499.6 EDP41562.1 - 9.5e-08 32.4 0.0 1.3e-07 32.0 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EDP41562.1 - 2.3e-07 29.9 0.1 2.6e-05 23.5 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EDP41562.1 - 1.2e-06 28.3 0.1 3.6e-06 26.7 0.0 1.7 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EDP41562.1 - 2.5e-06 27.0 0.1 2.9e-05 23.7 0.1 2.4 2 1 1 3 3 3 1 EF-hand domain EF-hand_9 PF14658.6 EDP41562.1 - 0.014 15.7 0.0 0.028 14.7 0.0 1.5 1 1 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 EDP41562.1 - 0.055 13.0 0.6 0.25 10.9 0.1 2.4 2 1 0 2 2 2 0 EF hand DUF2956 PF11169.8 EDP41563.1 - 0.12 12.6 2.2 0.2 11.8 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) AMMECR1 PF01871.17 EDP41564.1 - 2.7e-41 141.0 0.0 3.1e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 RF-1 PF00472.20 EDP41565.1 - 1e-21 77.0 4.3 1.9e-21 76.2 4.3 1.4 1 0 0 1 1 1 1 RF-1 domain Forkhead PF00250.18 EDP41566.1 - 3.6e-19 68.8 0.1 6e-19 68.1 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EDP41566.1 - 0.022 15.1 0.0 0.13 12.6 0.0 2.2 1 1 0 1 1 1 0 FHA domain TMEM208_SND2 PF05620.11 EDP41567.1 - 1.3e-39 135.7 0.9 2.2e-39 134.9 0.9 1.3 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF2070 PF09843.9 EDP41567.1 - 0.36 9.1 1.5 0.41 8.9 1.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ribosomal_S3Ae PF01015.18 EDP41568.1 - 1.4e-90 302.3 1.3 1.7e-90 302.1 1.3 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 EDP41568.1 - 0.091 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region SNF5 PF04855.12 EDP41569.1 - 1.3e-56 192.0 0.0 1.3e-55 188.8 0.0 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Sporozoite_P67 PF05642.11 EDP41569.1 - 0.078 11.1 0.7 0.16 10.1 0.7 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nucleo_P87 PF07267.11 EDP41569.1 - 0.33 9.8 2.7 1.6 7.5 0.2 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 RRM_1 PF00076.22 EDP41570.1 - 2.6e-07 30.3 0.0 4.1e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Flavokinase PF01687.17 EDP41572.1 - 1.4e-31 109.0 0.0 1.6e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase Thr_synth_N PF14821.6 EDP41573.1 - 1.6e-25 89.1 0.0 2.2e-24 85.4 0.0 2.4 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 EDP41573.1 - 9.7e-17 61.3 0.0 1.6e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WD40 PF00400.32 EDP41574.1 - 7e-09 36.2 10.1 0.00029 21.6 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41574.1 - 2.1e-08 34.3 0.1 0.0012 19.1 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PfkB PF00294.24 EDP41575.1 - 2.1e-35 122.5 0.1 2.4e-35 122.3 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase RNA_Me_trans PF04252.13 EDP41576.1 - 4.7e-54 183.0 0.0 6.2e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase SNARE_assoc PF09335.11 EDP41577.1 - 1.4e-11 44.9 8.0 3.6e-11 43.6 8.0 1.7 1 0 0 1 1 1 1 SNARE associated Golgi protein Sod_Fe_C PF02777.18 EDP41578.1 - 8.6e-18 64.4 0.0 1.7e-08 34.5 0.0 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDP41578.1 - 0.012 16.1 0.0 0.028 14.9 0.0 1.6 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Ndc1_Nup PF09531.10 EDP41579.1 - 3.1e-50 171.5 8.6 4.6e-50 171.0 8.6 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup RNA_pol PF00940.19 EDP41579.1 - 0.079 11.8 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 DNA-dependent RNA polymerase SOG2 PF10428.9 EDP41579.1 - 0.1 11.8 8.2 0.16 11.1 8.2 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 EDP41579.1 - 0.28 11.1 1.4 0.39 10.6 1.4 1.3 1 0 0 1 1 1 0 SPX domain MCM PF00493.23 EDP41580.1 - 4e-100 333.5 0.0 6.3e-100 332.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP41580.1 - 3.7e-29 101.1 0.0 6.3e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDP41580.1 - 2.2e-21 76.1 0.5 6.4e-21 74.6 0.5 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDP41580.1 - 2.8e-07 30.1 0.1 2.5e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDP41580.1 - 5.8e-07 29.6 0.0 2.6e-06 27.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM_N PF14551.6 EDP41580.1 - 4.9e-05 23.9 0.1 0.00018 22.1 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 EDP41580.1 - 0.0077 16.1 0.1 0.056 13.3 0.1 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDP41580.1 - 0.13 11.9 0.0 0.9 9.2 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain zf-UDP PF14569.6 EDP41580.1 - 0.25 11.5 0.6 0.53 10.4 0.6 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger AAA_lid_2 PF17863.1 EDP41580.1 - 1.8 8.5 4.9 0.92 9.4 0.2 3.0 3 0 0 3 3 3 0 AAA lid domain DUF2974 PF11187.8 EDP41582.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) LIM PF00412.22 EDP41583.1 - 7.1e-27 93.4 34.8 7.2e-14 51.8 7.9 4.0 3 1 0 3 3 3 3 LIM domain JAB PF01398.21 EDP41584.1 - 7.9e-17 61.3 0.0 1.9e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDP41584.1 - 8.2e-08 32.0 0.2 4.2e-07 29.8 0.1 2.2 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain GCP_N_terminal PF17681.1 EDP41585.1 - 5.7e-76 256.1 0.0 5.2e-75 252.9 0.0 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDP41585.1 - 4.6e-65 220.1 6.5 4.9e-65 220.0 5.0 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal ZapB PF06005.12 EDP41585.1 - 0.12 12.9 0.0 0.46 11.0 0.0 2.0 2 0 0 2 2 2 0 Cell division protein ZapB MarR_2 PF12802.7 EDP41585.1 - 0.15 12.0 0.0 0.15 12.0 0.0 2.9 3 0 0 3 3 3 0 MarR family ADH_N PF08240.12 EDP41586.1 - 6.9e-27 93.5 0.8 1.1e-26 92.8 0.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDP41586.1 - 1.2e-10 41.5 0.1 1.8e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EDP41586.1 - 1.5e-05 24.6 0.3 0.0063 16.0 0.1 2.3 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 EDP41586.1 - 0.02 14.1 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDP41586.1 - 0.15 10.7 0.1 0.32 9.7 0.2 1.4 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 EDP41586.1 - 0.18 11.1 0.2 0.27 10.4 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Ras PF00071.22 EDP41587.1 - 5.2e-48 162.7 0.5 5.9e-48 162.5 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP41587.1 - 9e-17 61.4 0.0 1.3e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP41587.1 - 3.5e-08 33.1 0.0 4.2e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDP41587.1 - 5.2e-05 23.3 0.0 6.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDP41587.1 - 0.00035 20.5 0.1 0.18 11.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDP41587.1 - 0.00041 19.9 0.2 0.0057 16.2 0.2 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EDP41587.1 - 0.00059 19.4 0.0 0.016 14.7 0.0 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 EDP41587.1 - 0.0014 18.1 0.1 0.0017 17.8 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RVT_3 PF13456.6 EDP41587.1 - 0.03 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like CaKB PF03185.15 EDP41587.1 - 0.11 12.2 0.3 0.7 9.5 0.1 1.9 1 1 1 2 2 2 0 Calcium-activated potassium channel, beta subunit AAA_14 PF13173.6 EDP41587.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RabGAP-TBC PF00566.18 EDP41588.1 - 5.1e-07 29.6 0.1 7.8e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Clat_adaptor_s PF01217.20 EDP41589.1 - 0.00028 20.8 0.0 0.00037 20.4 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain IQ PF00612.27 EDP41590.1 - 7.3e-19 65.7 32.0 0.0024 17.5 0.1 9.4 9 1 0 9 9 9 7 IQ calmodulin-binding motif CH PF00307.31 EDP41590.1 - 8.2e-16 58.2 0.0 1.4e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EDP41590.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Cu-oxidase_2 PF07731.14 EDP41591.1 - 6.1e-25 87.6 0.5 7.3e-25 87.3 0.5 1.1 1 0 0 1 1 1 1 Multicopper oxidase FH2 PF02181.23 EDP41592.1 - 2.2e-71 240.9 0.3 3.4e-71 240.4 0.3 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain ATP-synt_D PF01813.17 EDP41593.1 - 5.6e-68 228.6 0.0 7.3e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D ADK PF00406.22 EDP41595.1 - 3.7e-37 127.7 0.0 1.3e-36 126.0 0.0 1.7 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDP41595.1 - 1.7e-32 112.7 0.0 2.1e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP41595.1 - 1.7e-11 44.7 0.0 2.2e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP41595.1 - 2e-05 24.8 0.0 0.018 15.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain Thymidylate_kin PF02223.17 EDP41595.1 - 7.2e-05 22.5 0.0 0.00036 20.3 0.0 1.8 1 1 0 1 1 1 1 Thymidylate kinase Zeta_toxin PF06414.12 EDP41595.1 - 0.075 12.3 0.0 0.19 11.0 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin Ploopntkinase3 PF18751.1 EDP41595.1 - 0.086 12.7 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_19 PF13245.6 EDP41595.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain CLN3 PF02487.17 EDP41596.1 - 1.8e-80 271.0 4.5 9.7e-80 268.5 4.5 1.8 1 1 0 1 1 1 1 CLN3 protein Hol_Tox PF16935.5 EDP41596.1 - 0.07 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 Putative Holin-like Toxin (Hol-Tox) Snf7 PF03357.21 EDP41597.1 - 4.9e-33 114.1 17.9 9.4e-33 113.2 17.9 1.4 1 1 0 1 1 1 1 Snf7 TPR_MLP1_2 PF07926.12 EDP41597.1 - 0.14 12.2 5.9 0.24 11.5 5.3 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4123 PF13503.6 EDP41597.1 - 0.28 11.6 1.7 0.51 10.8 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4123) Peptidase_M2 PF01401.18 EDP41597.1 - 0.62 8.6 3.8 0.79 8.3 3.8 1.0 1 0 0 1 1 1 0 Angiotensin-converting enzyme PspA_IM30 PF04012.12 EDP41597.1 - 1.1 8.8 18.7 1.7 8.2 5.0 2.3 1 1 1 2 2 2 0 PspA/IM30 family YlqD PF11068.8 EDP41597.1 - 5.1 7.5 12.8 4.9 7.5 7.6 2.2 1 1 1 2 2 2 0 YlqD protein APG6_N PF17675.1 EDP41597.1 - 7.7 7.1 9.5 2.8 8.5 5.6 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Pkinase PF00069.25 EDP41598.1 - 2.7e-44 151.5 0.0 3.2e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP41598.1 - 1.6e-25 89.9 0.0 1.7e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP41598.1 - 5.8e-06 25.8 0.0 1.1e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDP41598.1 - 1.2e-05 24.3 0.0 1.7e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDP41598.1 - 0.00096 19.1 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EDP41598.1 - 0.0016 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 EDP41598.1 - 0.011 14.8 0.0 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EDP41598.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDP41598.1 - 0.031 13.9 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EDP41598.1 - 0.21 10.5 0.0 0.29 10.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Cyto_heme_lyase PF01265.17 EDP41599.1 - 7.6e-71 239.1 20.9 2.4e-56 191.5 8.8 3.7 1 1 2 3 3 3 2 Cytochrome c/c1 heme lyase SIS PF01380.22 EDP41600.1 - 1.3e-13 51.0 0.0 2.8e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EDP41600.1 - 0.023 14.7 0.4 0.069 13.2 0.3 1.8 1 1 1 2 2 2 0 SIS domain YTH PF04146.15 EDP41601.1 - 2.4e-35 121.9 0.1 3.9e-35 121.3 0.1 1.3 1 1 0 1 1 1 1 YT521-B-like domain DUF2961 PF11175.8 EDP41601.1 - 0.08 12.6 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) PorA PF11271.8 EDP41602.1 - 0.065 12.5 0.2 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 Porin PorA UCR_Fe-S_N PF10399.9 EDP41602.1 - 0.082 12.3 7.3 0.17 11.3 7.3 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Ribosomal_60s PF00428.19 EDP41602.1 - 0.11 13.1 3.7 0.2 12.3 3.7 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein CLASP_N PF12348.8 EDP41603.1 - 1.1e-12 48.0 0.1 7.8e-06 25.6 0.0 3.7 3 1 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 EDP41603.1 - 4.4e-07 29.6 9.7 0.99 9.8 0.3 7.0 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EDP41603.1 - 1.8e-05 24.8 0.0 1.3 9.0 0.2 4.3 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDP41603.1 - 0.00044 20.7 11.4 0.9 10.1 0.1 5.9 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 EDP41603.1 - 0.025 15.0 16.8 0.7 10.3 0.0 5.8 5 1 1 6 6 6 0 HEAT repeats Cohesin_HEAT PF12765.7 EDP41603.1 - 0.13 12.5 2.2 0.9 9.9 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 EDP41604.1 - 4.8e-07 29.6 0.0 6.5e-05 22.6 0.0 3.0 3 0 0 3 3 3 1 CLASP N terminal HEAT PF02985.22 EDP41604.1 - 0.00075 19.5 12.2 0.31 11.4 0.1 6.0 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EDP41604.1 - 0.0017 18.7 12.2 0.058 13.8 0.3 5.9 4 2 3 7 7 7 2 HEAT repeats MMS19_N PF14500.6 EDP41604.1 - 0.0077 15.8 0.1 11 5.5 0.0 3.7 4 0 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 EDP41604.1 - 0.028 14.9 6.7 1 10.0 0.1 5.0 5 0 0 5 5 5 0 HEAT-like repeat Transp_cyt_pur PF02133.15 EDP41605.1 - 8.5e-26 90.7 35.7 3.6e-25 88.7 35.7 1.8 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin HMGL-like PF00682.19 EDP41606.1 - 1.3e-79 267.5 0.8 1.3e-79 267.5 0.8 1.6 2 0 0 2 2 2 1 HMGL-like FliG_N PF14842.6 EDP41606.1 - 0.091 13.3 0.1 0.19 12.3 0.1 1.5 1 0 0 1 1 1 0 FliG N-terminal domain Dus PF01207.17 EDP41607.1 - 5.1e-40 137.5 0.0 7.3e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) EPSP_synthase PF00275.20 EDP41608.1 - 2.4e-122 408.7 0.1 3.8e-122 408.0 0.1 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EDP41608.1 - 5.1e-96 320.9 1.0 1.3e-95 319.5 0.3 1.9 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EDP41608.1 - 6.3e-56 190.2 0.0 1.3e-55 189.1 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 EDP41608.1 - 8.2e-25 86.9 0.0 2.7e-24 85.2 0.0 2.0 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EDP41608.1 - 5.7e-24 85.0 0.0 5.1e-22 78.7 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase Shikimate_DH PF01488.20 EDP41608.1 - 3.3e-08 33.7 0.0 7.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 EDP41608.1 - 5.1e-07 29.4 0.4 1.4e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 EDP41608.1 - 1.8e-06 27.9 0.3 1.8e-06 27.9 0.3 2.6 3 0 0 3 3 3 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.6 EDP41608.1 - 0.0016 18.6 0.0 0.01 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain UreF PF01730.16 EDP41608.1 - 0.063 13.9 0.2 0.26 11.9 0.2 2.1 1 0 0 1 1 1 0 UreF AAA_16 PF13191.6 EDP41608.1 - 0.097 13.0 0.1 0.81 10.0 0.0 2.6 2 1 1 3 3 3 0 AAA ATPase domain AAA_18 PF13238.6 EDP41608.1 - 0.18 12.4 0.0 0.35 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 EDP41609.1 - 1.3e-44 152.9 2.5 1.8e-44 152.5 2.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDP41609.1 - 4.6e-32 111.4 0.0 9.4e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 EDP41609.1 - 0.00018 20.9 0.0 0.00045 19.5 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin SMC_N PF02463.19 EDP41609.1 - 0.0015 18.1 0.2 0.017 14.6 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EDP41609.1 - 0.024 13.4 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class PsbW PF07123.12 EDP41609.1 - 0.027 14.5 0.6 0.083 12.9 0.3 2.0 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) CDP-OH_P_transf PF01066.21 EDP41610.1 - 4.2e-13 49.8 0.6 4.2e-13 49.8 0.6 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Hexapep PF00132.24 EDP41611.1 - 4.1e-12 45.3 1.1 5.8e-05 22.7 0.1 3.3 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDP41611.1 - 2.4e-05 24.0 6.6 0.0038 16.9 4.5 2.9 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 EDP41611.1 - 0.013 15.9 0.8 0.069 13.5 0.8 2.0 1 1 0 1 1 1 0 MobA-like NTP transferase domain NTP_transferase PF00483.23 EDP41611.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase DUF4954 PF16314.5 EDP41611.1 - 0.04 12.0 0.5 0.11 10.6 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EDP41611.1 - 0.077 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase MIF4G PF02854.19 EDP41612.1 - 1.2e-31 110.1 0.0 1.7e-16 60.5 0.1 3.7 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 EDP41612.1 - 8.1e-10 39.6 5.9 8.1e-10 39.6 5.9 3.6 4 1 0 4 4 4 1 Up-frameshift suppressor 2 PDE4_UCR PF18100.1 EDP41612.1 - 0.08 13.6 0.9 0.37 11.4 0.2 2.5 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) DUF4238 PF14022.6 EDP41612.1 - 0.16 11.5 3.0 0.5 9.8 3.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4238) KH_1 PF00013.29 EDP41613.1 - 1.1e-43 146.9 7.7 2.4e-16 59.3 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EDP41613.1 - 2.7e-14 52.8 9.3 9.6e-06 25.3 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EDP41613.1 - 5.9e-08 32.5 3.9 0.15 12.0 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EDP41613.1 - 0.0007 19.6 7.1 1 9.5 0.2 3.8 3 1 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 EDP41613.1 - 0.005 16.8 0.0 11 6.1 0.0 3.5 3 1 0 3 3 3 1 KH-like RNA-binding domain UDPGT PF00201.18 EDP41614.1 - 2.3e-08 33.3 0.0 1.1e-07 31.1 0.1 1.8 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase p450 PF00067.22 EDP41615.1 - 2.5e-61 207.8 0.2 6.4e-54 183.4 0.1 2.4 2 1 0 2 2 2 2 Cytochrome P450 dUTPase PF00692.19 EDP41616.1 - 1.2e-45 154.4 0.0 1.4e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase Pro_isomerase PF00160.21 EDP41617.1 - 6.7e-39 133.7 0.0 1.6e-38 132.5 0.0 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LMWPc PF01451.21 EDP41617.1 - 0.0055 17.1 0.1 0.012 16.0 0.1 1.5 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase RhoGAP PF00620.27 EDP41618.1 - 1.2e-33 116.1 0.3 2.6e-33 115.0 0.3 1.6 1 0 0 1 1 1 1 RhoGAP domain PX PF00787.24 EDP41618.1 - 0.0023 17.9 0.0 0.0053 16.7 0.0 1.6 1 0 0 1 1 1 1 PX domain DUF2232 PF09991.9 EDP41618.1 - 0.26 10.4 0.1 0.4 9.8 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Ran_BP1 PF00638.18 EDP41619.1 - 1.3e-21 77.1 1.2 2.2e-21 76.4 0.0 2.0 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.23 EDP41619.1 - 2e-07 30.9 0.0 4.2e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 WH1 domain DUF4889 PF16230.5 EDP41619.1 - 2.4 8.4 9.1 1.1 9.5 0.2 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4889) Usp PF00582.26 EDP41620.1 - 6.9e-17 62.3 0.3 2.6e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 Universal stress protein family Lon_C PF05362.13 EDP41621.1 - 7e-67 224.9 0.2 1.5e-66 223.9 0.2 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EDP41621.1 - 8.8e-33 113.9 0.0 8.8e-33 113.9 0.0 1.6 2 0 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EDP41621.1 - 2.3e-21 76.6 0.0 6.6e-21 75.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 EDP41621.1 - 3.2e-07 30.2 0.1 6.7e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EDP41621.1 - 4e-06 26.9 0.0 8.3e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 EDP41621.1 - 9.7e-06 24.7 0.0 1.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_2 PF07724.14 EDP41621.1 - 6.3e-05 23.2 0.0 0.00018 21.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EDP41621.1 - 0.00015 22.1 0.0 0.004 17.4 0.0 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EDP41621.1 - 0.00045 20.0 0.0 0.0018 18.0 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDP41621.1 - 0.0016 18.8 0.0 0.0048 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EDP41621.1 - 0.0022 18.6 0.7 0.0062 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain ClpB_D2-small PF10431.9 EDP41621.1 - 0.004 17.2 1.1 0.02 14.9 0.1 2.6 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_14 PF13173.6 EDP41621.1 - 0.0075 16.3 0.0 0.022 14.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain SKI PF01202.22 EDP41621.1 - 0.022 14.9 0.0 0.35 11.0 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase AAA_30 PF13604.6 EDP41621.1 - 0.032 13.9 0.0 0.098 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EDP41621.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 EDP41621.1 - 0.04 13.8 0.1 0.64 9.9 0.0 2.5 1 1 1 2 2 2 0 NTPase AAA_7 PF12775.7 EDP41621.1 - 0.048 13.2 0.3 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EDP41621.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 EDP41621.1 - 0.069 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EDP41621.1 - 0.071 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 EDP41621.1 - 0.086 12.0 0.2 0.33 10.1 0.1 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_3 PF07726.11 EDP41621.1 - 0.11 12.3 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDP41621.1 - 0.13 12.5 0.0 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDP41621.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDP41621.1 - 0.16 12.5 1.0 0.32 11.5 0.1 1.9 2 0 0 2 2 1 0 ABC transporter TsaE PF02367.17 EDP41621.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EDP41621.1 - 1.9 8.9 8.1 8.6 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DNA_pol_B PF00136.21 EDP41622.1 - 1.6e-149 498.5 0.4 2.1e-149 498.1 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDP41622.1 - 8.3e-83 278.3 0.0 2.3e-82 276.9 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDP41622.1 - 3.3e-13 49.9 11.1 7.3e-13 48.8 11.1 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EDP41622.1 - 0.0017 17.3 0.5 0.0079 15.1 0.1 2.1 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 EDP41622.1 - 0.02 14.6 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DUF1476 PF07345.11 EDP41622.1 - 0.16 12.3 0.6 19 5.7 0.2 2.6 2 0 0 2 2 2 0 ATPase inhibitor subunit zeta BMC PF00936.19 EDP41622.1 - 0.18 11.8 2.2 1.5 8.9 0.1 2.7 3 0 0 3 3 3 0 BMC domain Methyltr_RsmB-F PF01189.17 EDP41623.1 - 1.4e-71 240.3 0.0 2.4e-71 239.5 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EDP41623.1 - 8.7e-08 32.6 0.0 2.4e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 EDP41623.1 - 0.025 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.19 EDP41623.1 - 0.14 12.3 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase CNH PF00780.22 EDP41624.1 - 1.3e-74 251.3 0.0 2e-74 250.7 0.0 1.3 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 EDP41624.1 - 9.3e-47 158.5 0.0 1.9e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EDP41624.1 - 6.7e-36 124.2 0.4 1e-35 123.6 0.4 1.3 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EDP41624.1 - 7.6e-06 25.9 0.0 1.9e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RSN1_7TM PF02714.15 EDP41625.1 - 2.1e-54 184.7 31.3 2.1e-54 184.7 31.3 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EDP41625.1 - 7.8e-26 91.4 0.0 1.1e-25 90.8 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EDP41625.1 - 4.3e-15 55.8 1.2 4.3e-15 55.8 1.2 3.8 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport YjeF_N PF03853.15 EDP41626.1 - 1.2e-30 106.7 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus FMO-like PF00743.19 EDP41627.1 - 2.5e-19 69.1 0.1 1.3e-18 66.7 0.1 2.2 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EDP41627.1 - 1.6e-14 53.8 0.0 3.4e-13 49.5 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDP41627.1 - 1.9e-13 50.4 0.0 4.7e-10 39.2 0.1 3.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDP41627.1 - 5.4e-11 42.2 0.1 4.7e-06 26.0 0.0 3.0 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDP41627.1 - 1.4e-10 41.2 0.6 6.8e-10 39.0 0.0 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDP41627.1 - 1.5e-10 41.3 0.2 2.1e-07 30.8 0.2 2.8 2 1 1 4 4 4 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EDP41627.1 - 3.2e-09 37.2 2.7 0.0014 19.1 0.1 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP41627.1 - 7.6e-08 32.5 0.8 4.2e-05 23.6 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EDP41627.1 - 0.00012 21.6 0.0 0.009 15.3 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EDP41627.1 - 0.00013 20.8 0.8 0.013 14.3 0.0 2.5 3 0 0 3 3 3 1 HI0933-like protein Shikimate_DH PF01488.20 EDP41627.1 - 0.00025 21.1 0.0 0.88 9.6 0.0 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EDP41627.1 - 0.00038 19.8 0.2 0.0045 16.3 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EDP41627.1 - 0.00056 19.3 0.1 0.031 13.5 0.0 2.7 3 0 0 3 3 3 1 FAD binding domain 3HCDH_N PF02737.18 EDP41627.1 - 0.001 19.0 0.5 0.0021 18.0 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EDP41627.1 - 0.0038 16.3 0.0 0.19 10.7 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EDP41627.1 - 0.0051 16.1 2.2 0.33 10.2 0.1 2.4 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 EDP41627.1 - 0.007 16.8 0.0 3.3 8.2 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding GIDA PF01134.22 EDP41627.1 - 0.016 14.3 1.4 0.3 10.1 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EDP41627.1 - 0.033 13.3 0.0 0.033 13.3 0.0 1.5 2 0 0 2 2 1 0 FAD binding domain NAD_binding_2 PF03446.15 EDP41627.1 - 0.054 13.7 0.2 0.11 12.6 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 EDP41627.1 - 0.069 12.7 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.7 EDP41627.1 - 0.087 12.2 0.2 0.67 9.2 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 EDP41627.1 - 0.17 11.9 0.6 0.67 9.9 0.1 2.0 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 EDP41627.1 - 0.18 12.1 0.6 1 9.6 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain GATA PF00320.27 EDP41628.1 - 3.6e-14 52.1 8.1 1.8e-13 49.9 7.5 2.4 2 0 0 2 2 2 1 GATA zinc finger PQ-loop PF04193.14 EDP41629.1 - 4.9e-13 48.6 2.4 4.9e-13 48.6 2.4 1.8 2 0 0 2 2 2 1 PQ loop repeat Holin_2-3 PF13272.6 EDP41629.1 - 0.41 11.0 2.7 0.78 10.1 0.5 2.2 1 1 0 2 2 2 0 Putative 2/3 transmembrane domain holin PH PF00169.29 EDP41630.1 - 1.4e-05 25.5 0.0 2.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 PH domain DNApol_Exo PF18136.1 EDP41631.1 - 1.7e-82 276.7 0.0 2.6e-80 269.6 0.0 2.7 1 1 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EDP41631.1 - 1.3e-47 162.6 0.0 2.4e-47 161.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A Brr6_like_C_C PF10104.9 EDP41632.1 - 9.3e-42 142.0 0.3 1.1e-41 141.7 0.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Y_phosphatase2 PF03162.13 EDP41633.1 - 1.2e-26 93.2 0.0 1.2e-25 90.0 0.0 2.0 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDP41633.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Sad1_UNC PF07738.13 EDP41634.1 - 1.1e-27 96.6 0.0 1.2e-25 90.0 0.0 2.5 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal CLZ PF16526.5 EDP41634.1 - 5e-05 23.6 3.3 0.0092 16.3 0.0 3.1 2 1 1 3 3 3 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spc7 PF08317.11 EDP41634.1 - 0.00062 18.7 4.5 0.00062 18.7 4.5 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein Laminin_II PF06009.12 EDP41634.1 - 0.96 9.5 5.9 12 5.9 0.2 3.1 3 0 0 3 3 3 0 Laminin Domain II COG5 PF10392.9 EDP41634.1 - 6.9 6.9 7.3 4.5 7.4 0.4 3.0 3 0 0 3 3 3 0 Golgi transport complex subunit 5 FlxA PF14282.6 EDP41634.1 - 7.3 6.6 9.2 21 5.2 0.4 3.2 2 1 1 3 3 3 0 FlxA-like protein Aldo_ket_red PF00248.21 EDP41635.1 - 1.5e-45 155.6 0.1 7.7e-45 153.3 0.1 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family SHR3_chaperone PF08229.11 EDP41636.1 - 4.2e-40 136.7 0.5 4.9e-40 136.5 0.5 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Peptidase_M48_N PF16491.5 EDP41636.1 - 0.13 12.1 1.7 0.28 11.1 1.7 1.6 1 1 0 1 1 1 0 CAAX prenyl protease N-terminal, five membrane helices DBD_Tnp_Mut PF03108.15 EDP41637.1 - 1.5e-06 28.1 0.0 2.4e-05 24.2 0.0 2.5 2 0 0 2 2 2 1 MuDR family transposase MULE PF10551.9 EDP41637.1 - 0.002 18.5 0.0 0.0074 16.7 0.0 1.9 1 0 0 1 1 1 1 MULE transposase domain SWIM PF04434.17 EDP41637.1 - 0.0059 16.3 0.3 0.018 14.7 0.3 1.8 1 0 0 1 1 1 1 SWIM zinc finger zf-CCHC_6 PF15288.6 EDP41637.1 - 0.019 14.8 1.5 0.019 14.8 1.5 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 EDP41637.1 - 0.037 13.9 2.5 0.088 12.6 2.5 1.7 1 0 0 1 1 1 0 Zinc knuckle ERCC3_RAD25_C PF16203.5 EDP41638.1 - 4.3e-121 402.8 0.1 7.8e-121 401.9 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EDP41638.1 - 4.4e-38 130.3 0.0 9.5e-38 129.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP41638.1 - 3e-18 66.4 0.0 6.3e-18 65.3 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP41638.1 - 2.2e-11 44.1 0.1 6.8e-11 42.5 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EDP41638.1 - 6.1e-09 35.1 0.0 8.6e-09 34.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 EDP41638.1 - 3e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase URO-D PF01208.17 EDP41638.1 - 0.053 12.6 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) Dynactin_p62 PF05502.13 EDP41639.1 - 2.6e-45 155.1 22.7 9.3e-32 110.4 11.0 2.6 1 1 2 3 3 3 2 Dynactin p62 family AIP3 PF03915.13 EDP41640.1 - 8e-133 443.5 2.8 1.3e-132 442.8 2.8 1.3 1 0 0 1 1 1 1 Actin interacting protein 3 CHDCT2 PF08074.11 EDP41640.1 - 0.0016 18.6 2.6 0.13 12.4 0.1 2.6 1 1 1 2 2 2 2 CHDCT2 (NUC038) domain DUF1640 PF07798.11 EDP41640.1 - 0.25 11.3 5.9 0.086 12.9 2.4 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Prominin PF05478.11 EDP41640.1 - 0.58 8.0 4.9 0.37 8.7 1.2 1.9 1 1 1 2 2 2 0 Prominin Hemagglutinin PF00509.18 EDP41640.1 - 0.97 7.8 2.5 3.5 5.9 0.8 2.0 2 0 0 2 2 2 0 Haemagglutinin SpecificRecomb PF10136.9 EDP41640.1 - 1.4 7.1 3.1 1.8 6.8 2.1 1.6 2 0 0 2 2 2 0 Site-specific recombinase HMMR_N PF15905.5 EDP41640.1 - 7.3 6.0 9.9 0.35 10.3 0.5 2.7 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF3336 PF11815.8 EDP41642.1 - 9.2e-42 142.0 0.2 1.6e-41 141.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EDP41642.1 - 7.3e-17 62.2 0.1 1.8e-16 61.0 0.1 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase TadE PF07811.12 EDP41642.1 - 0.16 12.3 1.7 0.39 11.0 1.7 1.6 1 0 0 1 1 1 0 TadE-like protein XRN_M PF17846.1 EDP41643.1 - 1.4e-96 324.2 3.6 8.9e-96 321.5 3.7 2.0 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EDP41643.1 - 3.3e-72 242.8 0.0 6.4e-72 241.9 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EDP41643.1 - 2.3e-48 164.5 0.0 5.5e-48 163.3 0.0 1.7 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 EDP41643.1 - 7e-20 70.9 0.1 2.4e-19 69.2 0.1 1.9 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 EDP41643.1 - 1.1e-17 64.0 0.0 4.4e-17 62.1 0.0 2.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain PAPS_reduct PF01507.19 EDP41644.1 - 8.1e-19 68.3 0.0 1.3e-08 35.1 0.0 3.1 2 1 1 3 3 3 3 Phosphoadenosine phosphosulfate reductase family HCV_env PF01539.17 EDP41645.1 - 0.0063 16.2 0.0 0.0091 15.7 0.0 1.2 1 0 0 1 1 1 1 Hepatitis C virus envelope glycoprotein E1 Nop16 PF09420.10 EDP41646.1 - 3.2e-40 138.4 2.5 2.2e-38 132.4 2.5 2.0 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 Pkinase PF00069.25 EDP41647.1 - 1.5e-17 63.8 0.0 2.9e-08 33.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain HEAT PF02985.22 EDP41647.1 - 4e-15 54.6 3.7 0.013 15.7 0.0 6.3 6 0 0 6 6 5 3 HEAT repeat Pkinase_Tyr PF07714.17 EDP41647.1 - 1.4e-10 40.9 0.0 0.00064 19.1 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase WD40 PF00400.32 EDP41647.1 - 3.7e-10 40.2 20.5 2.5e-05 24.9 0.1 6.3 6 0 0 6 6 5 4 WD domain, G-beta repeat HEAT_2 PF13646.6 EDP41647.1 - 7.1e-09 35.9 0.0 0.0094 16.3 0.0 3.9 3 1 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 EDP41647.1 - 9.8e-07 29.2 0.2 0.0066 16.9 0.0 3.9 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 EDP41647.1 - 0.00096 19.2 4.4 15 5.6 1.6 4.4 2 2 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EDP41647.1 - 0.076 13.1 0.1 40 4.4 0.0 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat EH_Signature PF15611.6 EDP41647.1 - 0.08 12.3 0.0 0.37 10.2 0.0 2.0 2 0 0 2 2 2 0 EH_Signature domain Adaptin_N PF01602.20 EDP41647.1 - 0.12 10.9 4.3 0.43 9.1 4.2 2.0 1 1 0 1 1 1 0 Adaptin N terminal region Proteasom_PSMB PF10508.9 EDP41647.1 - 0.22 10.0 0.7 0.43 9.0 0.5 1.5 1 1 0 1 1 1 0 Proteasome non-ATPase 26S subunit Actin PF00022.19 EDP41648.1 - 3.4e-88 296.0 0.0 1.8e-55 188.2 0.0 2.0 1 1 1 2 2 2 2 Actin Robl_LC7 PF03259.17 EDP41648.1 - 0.093 12.5 0.1 4.8 7.0 0.0 2.3 2 0 0 2 2 2 0 Roadblock/LC7 domain Acetyltransf_1 PF00583.25 EDP41649.1 - 6.6e-12 45.7 0.0 1e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDP41649.1 - 7.6e-08 32.7 0.0 1.1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDP41649.1 - 2.7e-05 24.1 0.1 0.00011 22.1 0.1 1.9 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EDP41649.1 - 5.1e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EDP41649.1 - 0.053 13.2 0.0 0.94 9.2 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EDP41649.1 - 0.089 12.9 0.0 0.41 10.7 0.0 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EDP41649.1 - 0.12 13.0 0.0 0.15 12.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CBX7_C PF17218.3 EDP41649.1 - 0.14 11.9 0.4 0.26 11.1 0.4 1.5 1 0 0 1 1 1 0 CBX family C-terminal motif PRMT5_TIM PF17285.2 EDP41650.1 - 1e-61 208.4 0.0 1.5e-61 207.8 0.0 1.3 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 EDP41650.1 - 9.4e-50 168.9 0.0 1.5e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5 PF05185.16 EDP41650.1 - 8.2e-49 165.8 0.0 1.6e-48 164.8 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_25 PF13649.6 EDP41650.1 - 7.4e-05 23.4 0.0 0.00016 22.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP41650.1 - 0.0087 16.7 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_20 PF12147.8 EDP41650.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase RRM_1 PF00076.22 EDP41651.1 - 3.1e-18 65.3 0.3 8.1e-18 64.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP41651.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CS PF04969.16 EDP41652.1 - 0.00099 20.1 0.0 0.0019 19.1 0.0 1.5 1 0 0 1 1 1 1 CS domain CRIM PF16978.5 EDP41653.1 - 6.3e-17 62.0 0.0 1.6e-16 60.8 0.0 1.6 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain Aconitase PF00330.20 EDP41654.1 - 5.9e-148 493.7 0.0 7.4e-148 493.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDP41654.1 - 1.5e-43 148.2 0.0 3e-43 147.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Pyr_redox_2 PF07992.14 EDP41655.1 - 3.6e-49 167.6 0.2 4.2e-49 167.4 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDP41655.1 - 1.3e-16 60.7 0.1 5.1e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP41655.1 - 1.5e-16 60.7 0.2 7.7e-14 52.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDP41655.1 - 5.4e-05 22.5 0.5 0.00049 19.4 0.0 2.3 2 1 1 3 3 3 1 Thi4 family FAD_oxidored PF12831.7 EDP41655.1 - 6.6e-05 22.4 0.1 0.02 14.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EDP41655.1 - 8.2e-05 21.8 1.7 0.0064 15.6 0.0 3.2 4 1 0 4 4 4 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDP41655.1 - 0.00048 20.3 0.5 0.0089 16.2 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EDP41655.1 - 0.0034 17.8 0.3 0.22 11.9 0.0 3.0 2 2 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EDP41655.1 - 0.005 16.0 3.1 0.035 13.2 1.0 2.4 2 1 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 EDP41655.1 - 0.012 14.9 0.1 0.04 13.1 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain K_oxygenase PF13434.6 EDP41655.1 - 0.012 14.7 0.1 0.48 9.5 0.0 2.8 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 EDP41655.1 - 0.013 14.4 0.2 0.056 12.3 0.1 1.8 2 0 0 2 2 2 0 Tryptophan halogenase DAO PF01266.24 EDP41655.1 - 0.015 14.9 0.6 0.03 13.9 0.6 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDP41655.1 - 0.028 13.1 0.2 0.11 11.2 0.4 1.8 2 0 0 2 2 2 0 HI0933-like protein Shikimate_DH PF01488.20 EDP41655.1 - 0.052 13.6 0.0 13 5.8 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase COesterase PF00135.28 EDP41656.1 - 1.9e-64 218.4 3.3 1.8e-61 208.6 0.2 2.1 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EDP41656.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ribosomal_L4 PF00573.22 EDP41657.1 - 6.2e-41 140.2 0.3 1.1e-40 139.4 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EDP41657.1 - 5.8e-29 100.0 0.3 5.8e-29 100.0 0.3 2.8 2 1 1 3 3 3 1 60S ribosomal protein L4 C-terminal domain PAPS_reduct PF01507.19 EDP41658.1 - 7.4e-40 136.8 0.0 9.3e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF3395 PF11875.8 EDP41659.1 - 6.6e-46 156.1 0.4 1.4e-45 155.0 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EDP41659.1 - 1.8e-10 40.8 0.9 3e-10 40.1 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain LSM PF01423.22 EDP41660.1 - 1.3e-07 31.2 0.0 1.4e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 LSM domain Root_cap PF06830.11 EDP41660.1 - 0.11 12.6 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Root cap Redoxin PF08534.10 EDP41661.1 - 7.4e-30 103.6 0.0 8.2e-30 103.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EDP41661.1 - 4.4e-08 33.1 0.0 6e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF3384 PF11864.8 EDP41662.1 - 1.1e-46 159.8 3.2 3.4e-46 158.1 3.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EDP41662.1 - 1.8e-43 148.3 0.0 3.4e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EDP41662.1 - 2.4e-41 142.1 9.0 3.5e-36 125.0 6.3 3.2 2 1 0 2 2 2 2 Tuberin HAD_2 PF13419.6 EDP41663.1 - 0.0082 16.3 0.0 0.095 12.8 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_47 PF01532.20 EDP41664.1 - 1.8e-144 482.1 0.0 2.2e-144 481.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 LRR_6 PF13516.6 EDP41665.1 - 8.6e-15 53.5 24.1 0.045 13.8 0.0 8.7 10 0 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.7 EDP41665.1 - 1e-05 25.8 10.2 0.17 12.4 0.2 5.8 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP41665.1 - 0.0063 16.2 16.7 0.52 10.1 0.1 5.5 5 1 0 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 EDP41665.1 - 0.011 16.2 10.4 6.9 7.6 0.1 7.2 8 0 0 8 8 8 0 Leucine Rich Repeat HEAT PF02985.22 EDP41666.1 - 1.5 9.3 10.9 15 6.2 0.1 6.4 5 0 0 5 5 5 0 HEAT repeat UCH PF00443.29 EDP41667.1 - 2.1e-32 112.6 0.1 3e-32 112.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EDP41667.1 - 1.3e-16 60.2 2.9 4e-15 55.5 0.2 3.3 3 0 0 3 3 3 1 A repeated domain in UCH-protein UCH_1 PF13423.6 EDP41667.1 - 2.7e-07 30.5 0.2 0.0051 16.4 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rer1 PF03248.13 EDP41668.1 - 9.2e-64 214.3 2.5 1.1e-63 214.0 2.5 1.0 1 0 0 1 1 1 1 Rer1 family Cupin_8 PF13621.6 EDP41669.1 - 4.3e-28 98.7 0.0 9.8e-28 97.5 0.0 1.5 1 1 1 2 2 2 1 Cupin-like domain RNA_pol_3_Rpc31 PF11705.8 EDP41669.1 - 0.0014 18.9 2.2 0.0014 18.9 2.2 1.6 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 CNDH2_C PF16858.5 EDP41669.1 - 0.056 13.3 2.8 0.087 12.7 2.8 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NOA36 PF06524.12 EDP41669.1 - 1.1 8.5 15.9 0.15 11.4 11.4 1.7 2 0 0 2 2 2 0 NOA36 protein Nop25 PF09805.9 EDP41669.1 - 1.2 9.6 9.1 0.43 11.1 5.8 1.7 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) LIP PF03583.14 EDP41670.1 - 6.6e-58 196.3 0.2 8.7e-58 195.9 0.2 1.1 1 0 0 1 1 1 1 Secretory lipase DLH PF01738.18 EDP41670.1 - 0.0078 15.8 0.1 2.2 7.8 0.0 2.9 2 1 1 3 3 3 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EDP41670.1 - 0.094 12.5 0.1 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase LIP PF03583.14 EDP41671.1 - 2.8e-62 210.6 0.0 3.5e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Asp PF00026.23 EDP41672.1 - 9.4e-48 163.2 2.2 4.8e-47 160.9 2.2 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDP41672.1 - 1.6e-10 41.5 1.1 4.3e-05 23.8 0.9 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDP41672.1 - 3.9e-08 33.8 0.1 0.002 18.8 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP41672.1 - 1.1e-07 32.4 0.0 0.0021 18.6 0.0 2.5 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease LIP PF03583.14 EDP41673.1 - 8.6e-60 202.5 0.0 1.1e-59 202.1 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 EDP41673.1 - 0.00026 20.5 0.3 0.2 11.1 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Cu-oxidase_3 PF07732.15 EDP41674.1 - 5.1e-18 65.2 0.0 6.3e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDP41674.1 - 0.02 14.7 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Multicopper oxidase DUF3615 PF12274.8 EDP41674.1 - 0.073 13.6 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) DEAD PF00270.29 EDP41676.1 - 1.7e-20 73.5 0.0 4.6e-20 72.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.10 EDP41676.1 - 3.6e-20 71.9 0.0 6.9e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 EDP41676.1 - 4.2e-18 65.7 0.1 1.1e-16 61.1 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EDP41676.1 - 2.2e-15 57.1 5.6 2.4e-15 57.0 3.4 2.3 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EDP41676.1 - 0.0077 16.2 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit 6PGD PF00393.19 EDP41677.1 - 7.5e-125 416.1 0.0 9.2e-125 415.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EDP41677.1 - 1.9e-52 177.6 0.0 2.9e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EDP41677.1 - 0.0067 17.0 0.1 0.016 15.8 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EDP41677.1 - 0.18 11.1 0.0 0.38 10.1 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPR_1 PF00515.28 EDP41678.1 - 6.5e-29 98.5 1.2 1.4e-08 34.2 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDP41678.1 - 1.7e-21 74.5 1.4 4.1e-07 29.6 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDP41678.1 - 1.2e-18 66.5 4.8 1.2e-07 31.3 0.8 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 EDP41678.1 - 3.9e-18 64.1 1.1 5.7e-06 26.1 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP41678.1 - 6e-14 51.3 0.9 2e-06 27.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP41678.1 - 2.3e-12 46.6 0.2 9.7e-05 22.9 0.0 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP41678.1 - 7.6e-11 42.5 0.6 8.9e-06 26.3 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP41678.1 - 1.3e-09 38.5 0.7 6.2e-06 26.6 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDP41678.1 - 2e-08 33.8 1.6 0.0041 16.9 0.5 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP41678.1 - 2.4e-08 33.4 0.2 0.0011 18.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP41678.1 - 3.4e-08 33.6 3.9 5.6e-06 26.6 1.3 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EDP41678.1 - 8.4e-06 26.3 0.2 4.3e-05 24.0 0.1 2.0 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 EDP41678.1 - 3.5e-05 23.2 0.2 0.00011 21.5 0.1 1.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDP41678.1 - 0.00026 21.1 0.0 0.022 14.9 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP41678.1 - 0.0077 16.8 2.4 4.9 8.0 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDP41678.1 - 0.014 16.0 0.0 3 8.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EDP41678.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal MIT PF04212.18 EDP41678.1 - 0.56 10.3 8.4 2.2 8.4 0.6 3.3 3 1 1 4 4 3 0 MIT (microtubule interacting and transport) domain STI1 PF17830.1 EDP41678.1 - 1.3 9.0 15.8 3.1 7.8 1.4 3.1 1 1 0 2 2 2 0 STI1 domain Com_YlbF PF06133.11 EDP41678.1 - 1.8 9.2 7.4 0.67 10.6 0.2 3.0 3 1 0 3 3 2 0 Control of competence regulator ComK, YlbF/YmcA Sterol-sensing PF12349.8 EDP41679.1 - 4.9e-38 130.4 10.5 9.9e-38 129.4 10.5 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EDP41679.1 - 4.7e-08 31.6 8.0 6.5e-08 31.1 8.0 1.1 1 0 0 1 1 1 1 Patched family Rad21_Rec8_N PF04825.13 EDP41681.1 - 8.9e-31 106.3 0.0 1.7e-30 105.4 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EDP41681.1 - 1.9e-10 39.9 0.0 3.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Aa_trans PF01490.18 EDP41682.1 - 3.5e-44 151.2 12.7 2.8e-43 148.2 8.5 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Aa_trans PF01490.18 EDP41683.1 - 9.9e-12 44.3 0.7 1.2e-11 44.0 0.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EDP41683.1 - 0.00094 18.3 1.8 0.0012 18.0 1.8 1.1 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family RhoGAP PF00620.27 EDP41684.1 - 1.7e-36 125.3 0.1 3.3e-36 124.4 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EDP41684.1 - 1.2e-28 99.1 30.0 5.1e-13 49.0 2.9 4.8 5 0 0 5 5 5 4 LIM domain NinD PF17466.2 EDP41684.1 - 0.14 12.3 3.7 0.18 11.9 1.7 2.3 2 0 0 2 2 2 0 Family of unknown function F-box-like PF12937.7 EDP41685.1 - 3e-05 23.8 0.0 8.5e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EDP41685.1 - 0.002 17.9 2.8 0.022 14.6 0.6 2.5 2 0 0 2 2 2 1 F-box domain Ank_2 PF12796.7 EDP41686.1 - 9.7e-12 45.3 2.6 5.6e-05 23.6 0.2 3.7 2 1 3 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP41686.1 - 5.7e-09 36.3 4.7 0.011 16.3 0.1 4.6 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP41686.1 - 5.1e-08 32.6 5.9 0.0032 17.8 0.0 5.5 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EDP41686.1 - 3.2e-07 30.5 6.7 0.0022 18.2 0.0 4.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EDP41686.1 - 1.6e-06 28.3 8.7 0.0097 16.3 0.1 5.2 4 2 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 EDP41686.1 - 0.00012 21.9 0.1 0.00073 19.4 0.1 2.0 1 1 0 1 1 1 1 KilA-N domain Spc7 PF08317.11 EDP41686.1 - 0.057 12.3 7.1 0.25 10.2 3.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein CC2-LZ PF16516.5 EDP41686.1 - 0.91 9.9 6.1 6.7 7.1 0.7 2.6 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Sporozoite_P67 PF05642.11 EDP41686.1 - 5.1 5.0 12.6 10 4.1 12.6 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF641 PF04859.12 EDP41686.1 - 9.3 6.6 7.9 5.9 7.2 3.0 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) SH3_1 PF00018.28 EDP41687.1 - 1.1e-40 137.0 1.2 2.6e-13 49.4 0.0 3.8 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 EDP41687.1 - 4.1e-35 119.4 8.0 4.5e-12 45.6 0.1 4.1 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EDP41687.1 - 2.9e-20 71.7 0.0 5.4e-07 29.2 0.0 4.1 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 EDP41687.1 - 2.8e-19 68.7 0.0 5.4e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SAM_4 PF18017.1 EDP41687.1 - 0.00014 21.8 0.0 0.00034 20.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_10 PF17902.1 EDP41687.1 - 0.00016 21.7 0.1 0.0032 17.5 0.0 2.9 3 0 0 3 3 3 1 SH3 domain SH3_3 PF08239.11 EDP41687.1 - 0.0033 17.7 0.5 3.3 8.0 0.0 3.3 3 0 0 3 3 3 1 Bacterial SH3 domain SAM_1 PF00536.30 EDP41687.1 - 0.04 14.3 0.0 0.076 13.5 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SPESP1 PF15754.5 EDP41687.1 - 0.99 8.5 10.3 2.6 7.2 10.3 1.6 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 START PF01852.19 EDP41688.1 - 8.6e-15 54.7 2.2 2.5e-05 23.8 0.0 3.5 3 0 0 3 3 3 3 START domain Pex14_N PF04695.13 EDP41688.1 - 0.00075 20.2 3.2 0.00075 20.2 3.2 4.5 4 0 0 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DDHD PF02862.17 EDP41688.1 - 0.18 11.9 5.8 0.3 11.2 0.9 2.6 2 0 0 2 2 2 0 DDHD domain CSG2 PF16965.5 EDP41688.1 - 0.27 10.1 1.4 0.5 9.3 1.4 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator EPL1 PF10513.9 EDP41688.1 - 2.4 8.5 8.1 0.84 10.0 1.4 3.0 3 0 0 3 3 3 0 Enhancer of polycomb-like Neur_chan_memb PF02932.16 EDP41688.1 - 3.3 7.7 9.9 2 8.4 1.5 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EDP41688.1 - 3.5 6.3 12.8 0.099 11.4 2.4 2.4 2 0 0 2 2 2 0 Presenilin Zip PF02535.22 EDP41688.1 - 5 6.2 6.6 0.22 10.7 0.4 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Apt1 PF10351.9 EDP41688.1 - 5 5.9 14.8 1 8.1 2.5 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Mak16 PF04874.14 EDP41689.1 - 2.7e-26 92.1 22.2 8.2e-26 90.5 22.2 1.8 1 1 0 1 1 1 1 Mak16 protein C-terminal region PYC_OADA PF02436.18 EDP41689.1 - 0.0078 16.0 1.4 0.011 15.4 0.3 1.7 1 1 0 1 1 1 1 Conserved carboxylase domain GSH_synthase PF03199.15 EDP41689.1 - 0.02 15.3 0.2 0.049 14.1 0.2 1.6 1 0 0 1 1 1 0 Eukaryotic glutathione synthase Pkinase_Tyr PF07714.17 EDP41690.1 - 1.3e-41 142.6 0.0 1.6e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EDP41690.1 - 8.5e-40 136.8 0.0 1.1e-39 136.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EDP41690.1 - 0.015 14.2 0.1 0.37 9.7 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EDP41690.1 - 0.041 13.8 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP41690.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Nitroreductase PF00881.24 EDP41691.1 - 3.8e-20 72.6 0.0 4.5e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Nitroreductase PF00881.24 EDP41692.1 - 1.2e-12 48.2 0.0 1.4e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Cyclin PF08613.11 EDP41694.1 - 5.7e-22 78.8 0.5 6.6e-22 78.6 0.5 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EDP41694.1 - 0.0048 16.6 0.5 0.0062 16.3 0.5 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF1673 PF07895.11 EDP41694.1 - 0.081 12.6 0.3 0.099 12.3 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Prp18 PF02840.15 EDP41695.1 - 3.1e-33 114.9 0.5 6.3e-33 113.8 0.0 1.7 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EDP41695.1 - 3.7e-11 42.4 3.3 8.3e-11 41.3 3.3 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Transformer PF06495.11 EDP41695.1 - 1 9.4 7.4 1.8 8.6 7.4 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein LcrG PF07216.12 EDP41695.1 - 1.4 8.9 5.7 0.34 10.9 0.9 2.4 2 1 0 2 2 2 0 LcrG protein COX6B PF02297.17 EDP41696.1 - 4.1e-15 55.8 5.7 4.9e-15 55.5 5.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb DUF717 PF05338.12 EDP41696.1 - 0.39 10.9 2.7 0.3 11.2 1.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF717) Med1 PF10744.9 EDP41697.1 - 1e-05 24.8 0.3 0.23 10.4 0.1 3.3 2 2 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 DAGK_cat PF00781.24 EDP41699.1 - 6.1e-14 51.7 0.0 1.4e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EDP41699.1 - 0.094 11.9 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase Methyltransf_23 PF13489.6 EDP41700.1 - 1.9e-06 27.8 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP41700.1 - 0.00014 22.5 0.0 0.00043 21.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.6 EDP41700.1 - 0.0011 20.0 0.1 0.0023 19.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP41700.1 - 0.0019 18.9 0.0 0.0036 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP41700.1 - 0.0019 18.8 0.0 0.0037 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain LBP_M PF17385.2 EDP41700.1 - 0.13 11.7 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain LEA_2 PF03168.13 EDP41701.1 - 0.0057 17.2 0.0 0.0099 16.4 0.0 1.3 1 0 0 1 1 1 1 Late embryogenesis abundant protein Cpn60_TCP1 PF00118.24 EDP41702.1 - 4.3e-154 513.8 13.6 5.2e-154 513.5 13.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA_14 PF13173.6 EDP41702.1 - 0.037 14.0 0.0 0.097 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain UFD1 PF03152.14 EDP41703.1 - 1.8e-55 187.1 0.0 1.2e-32 112.8 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin fusion degradation protein UFD1 RraA-like PF03737.15 EDP41704.1 - 2.3e-27 96.0 0.0 3.2e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Aldolase/RraA DUF3808 PF10300.9 EDP41705.1 - 4.5e-65 220.2 0.0 8e-65 219.4 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EDP41705.1 - 4.3e-06 26.4 13.8 0.0081 16.2 1.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP41705.1 - 6e-06 25.8 8.5 0.26 11.2 0.3 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP41705.1 - 0.00078 19.3 6.0 1.7 8.8 0.6 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP41705.1 - 0.0077 16.4 6.4 7.5 7.0 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP41705.1 - 0.019 15.5 0.2 10 6.7 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDP41705.1 - 0.054 13.8 1.7 9.9 6.5 0.2 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP41705.1 - 0.099 13.3 0.8 47 4.9 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDP41705.1 - 0.16 12.4 1.7 0.72 10.4 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat CRAL_TRIO PF00650.20 EDP41706.1 - 3.1e-31 108.3 0.1 5.6e-31 107.4 0.1 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDP41706.1 - 2.8e-10 40.5 0.0 4.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDP41706.1 - 1.7e-08 34.5 0.0 5.1e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Mito_fiss_reg PF05308.11 EDP41707.1 - 3.7 7.5 9.3 0.17 11.9 2.8 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator GAF_2 PF13185.6 EDP41708.1 - 0.061 13.6 0.0 0.31 11.3 0.0 1.9 2 0 0 2 2 2 0 GAF domain Abhydrolase_1 PF00561.20 EDP41709.1 - 5.5e-40 137.6 0.0 2e-39 135.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EDP41709.1 - 0.0048 16.6 0.0 0.0075 15.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EDP41709.1 - 0.084 12.1 0.0 2.9 7.1 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 tRNA-synt_His PF13393.6 EDP41710.1 - 1.9e-39 135.8 0.3 5.7e-34 117.8 0.0 2.3 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EDP41710.1 - 5.3e-08 32.9 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 EDP41710.1 - 0.0033 17.0 0.0 0.0068 16.0 0.0 1.5 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 EDP41710.1 - 0.32 10.0 2.1 3.4 6.7 0.8 2.8 2 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) Use1 PF09753.9 EDP41711.1 - 1.7e-16 60.7 0.0 2.2e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 Macoilin PF09726.9 EDP41711.1 - 0.13 10.8 2.9 0.13 10.8 2.9 1.1 1 0 0 1 1 1 0 Macoilin family Dehydrin PF00257.19 EDP41711.1 - 0.13 12.8 2.9 0.25 11.9 2.9 1.4 1 0 0 1 1 1 0 Dehydrin Apt1 PF10351.9 EDP41711.1 - 0.68 8.7 5.1 0.79 8.5 5.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ribonuc_L-PSP PF01042.21 EDP41712.1 - 8.8e-42 141.9 0.3 1.2e-41 141.6 0.3 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP RhoGEF PF00621.20 EDP41713.1 - 1.4e-14 54.7 0.3 2.2e-13 50.9 0.3 2.2 1 1 0 1 1 1 1 RhoGEF domain Ndufs5 PF10200.9 EDP41714.1 - 0.00075 19.7 0.8 0.0013 19.0 0.8 1.5 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 EDP41714.1 - 0.0025 18.2 0.9 0.0036 17.6 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Pet191_N PF10203.9 EDP41714.1 - 0.11 12.8 1.1 0.2 12.0 1.1 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EDP41714.1 - 0.18 11.9 3.8 0.43 10.6 3.8 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Gpi1 PF05024.15 EDP41715.1 - 2.8e-47 161.2 9.3 4.9e-47 160.4 9.3 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Ras PF00071.22 EDP41716.1 - 1.5e-58 197.0 0.1 2e-58 196.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP41716.1 - 8.2e-37 126.1 0.1 1.2e-36 125.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP41716.1 - 8.7e-16 57.9 0.1 1.1e-15 57.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDP41716.1 - 2.3e-05 24.0 0.0 0.00012 21.7 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDP41716.1 - 0.00015 21.8 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EDP41716.1 - 0.00021 20.8 0.0 0.00026 20.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDP41716.1 - 0.00026 20.4 0.1 0.00034 20.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EDP41716.1 - 0.0042 17.0 0.1 2.4 8.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Seipin PF06775.14 EDP41717.1 - 6.7e-51 173.2 0.2 1.2e-50 172.4 0.2 1.4 1 1 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) TAP42 PF04177.12 EDP41718.1 - 5.7e-65 219.5 0.3 7.2e-65 219.2 0.3 1.0 1 0 0 1 1 1 1 TAP42-like family CENP-B_dimeris PF09026.10 EDP41718.1 - 0.72 10.3 8.5 0.25 11.7 1.8 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DAGK_cat PF00781.24 EDP41719.1 - 1.8e-22 79.3 0.0 3.3e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EDP41719.1 - 0.0065 15.7 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Thioredoxin PF00085.20 EDP41720.1 - 1.1e-53 179.6 0.0 7.5e-26 90.1 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EDP41720.1 - 5.1e-24 85.0 0.1 5.1e-24 85.0 0.1 2.8 3 0 0 3 3 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 EDP41720.1 - 2.7e-17 63.1 0.0 8.3e-11 41.8 0.0 2.3 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EDP41720.1 - 1.3e-13 51.3 0.2 2.4e-05 24.7 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDP41720.1 - 2.8e-11 43.6 0.2 4.8e-05 23.6 0.1 3.6 2 2 1 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EDP41720.1 - 6.4e-09 35.9 0.1 0.0016 18.6 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EDP41720.1 - 1.7e-08 34.4 0.1 0.004 17.1 0.0 2.5 2 0 0 2 2 2 2 AhpC/TSA family TraF PF13728.6 EDP41720.1 - 7e-07 29.3 0.0 0.025 14.4 0.0 2.6 2 0 0 2 2 2 2 F plasmid transfer operon protein ERp29_N PF07912.13 EDP41720.1 - 2.2e-06 27.8 0.0 0.016 15.3 0.0 2.4 2 0 0 2 2 2 2 ERp29, N-terminal domain Redoxin PF08534.10 EDP41720.1 - 9e-05 22.2 0.1 0.086 12.5 0.0 2.3 2 0 0 2 2 2 2 Redoxin DDE_Tnp_1_2 PF13586.6 EDP41720.1 - 0.00052 20.3 0.0 0.63 10.5 0.0 2.6 2 0 0 2 2 2 2 Transposase DDE domain HyaE PF07449.11 EDP41720.1 - 0.0014 18.6 0.0 1.6 8.7 0.0 2.7 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Apolipoprotein PF01442.18 EDP41720.1 - 0.03 14.2 3.8 0.12 12.3 3.8 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF953 PF06110.11 EDP41720.1 - 0.056 13.1 0.1 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Phage_Mu_Gam PF07352.12 EDP41720.1 - 0.094 12.6 1.5 0.18 11.7 0.4 2.1 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Thioredoxin_9 PF14595.6 EDP41720.1 - 0.1 12.4 0.1 21 4.9 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 EDP41720.1 - 0.11 12.7 3.1 4.3 7.5 0.0 2.9 3 1 0 3 3 3 0 Thioredoxin Glutaredoxin PF00462.24 EDP41720.1 - 0.17 12.1 6.0 2.6 8.3 1.0 3.3 2 2 0 2 2 2 0 Glutaredoxin Mu-like_Com PF10122.9 EDP41720.1 - 0.38 10.2 1.5 24 4.5 0.1 2.8 2 0 0 2 2 2 0 Mu-like prophage protein Com Amidohydro_1 PF01979.20 EDP41721.1 - 7e-64 216.3 0.8 1.1e-63 215.7 0.8 1.2 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EDP41721.1 - 4.8e-53 178.6 0.7 1e-52 177.5 0.7 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 EDP41721.1 - 1.2e-36 125.0 0.0 2.4e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 EDP41721.1 - 1.2e-25 89.4 0.0 2.5e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_3 PF07969.11 EDP41721.1 - 1.1e-07 31.8 0.3 9.1e-05 22.1 0.0 2.8 2 1 0 2 2 2 2 Amidohydrolase family Abi_C PF14355.6 EDP41721.1 - 0.042 13.9 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 Abortive infection C-terminus ubiquitin PF00240.23 EDP41722.1 - 2.3e-22 78.5 0.4 2.5e-22 78.4 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDP41722.1 - 1.7e-13 50.2 0.4 2e-13 49.9 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDP41722.1 - 0.0044 17.4 0.0 0.013 15.9 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDP41722.1 - 0.014 15.4 0.0 0.015 15.2 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDP41722.1 - 0.11 12.6 0.4 16 5.6 0.3 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain AhpC-TSA PF00578.21 EDP41723.1 - 9.4e-05 22.3 0.0 0.00011 22.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family UEV PF05743.13 EDP41724.1 - 1.3e-07 31.5 0.0 2.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 UEV domain TelA PF05816.11 EDP41724.1 - 0.0088 15.1 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DEAD PF00270.29 EDP41725.1 - 6.5e-08 32.5 0.1 1.1e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP41725.1 - 4.3e-05 23.8 0.0 0.00014 22.1 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DHH PF01368.20 EDP41726.1 - 1.2e-11 44.7 0.0 1.7e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 DHH family Pox_A32 PF04665.12 EDP41726.1 - 0.0046 16.5 0.1 0.02 14.4 0.1 1.8 2 0 0 2 2 2 1 Poxvirus A32 protein DUF3678 PF12435.8 EDP41726.1 - 0.15 11.5 3.3 1.3 8.4 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3678) DHHA2 PF02833.14 EDP41727.1 - 3.7e-18 66.1 0.0 4.7e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 DHHA2 domain Iron_traffic PF04362.14 EDP41727.1 - 0.035 13.8 0.2 0.063 13.0 0.2 1.4 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking DUF155 PF02582.14 EDP41728.1 - 2.2e-47 161.4 0.0 3.5e-47 160.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF2457 PF10446.9 EDP41728.1 - 0.0041 16.3 7.5 0.0041 16.3 7.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 EDP41728.1 - 1.3 8.8 11.7 0.098 12.4 5.0 2.4 3 0 0 3 3 3 0 Pox virus Ag35 surface protein NOA36 PF06524.12 EDP41728.1 - 1.6 8.0 19.6 3 7.1 19.6 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EDP41728.1 - 7.4 7.0 20.4 34 4.9 20.4 2.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Vps54 PF07928.12 EDP41729.1 - 1.1e-45 155.4 2.5 6.7e-45 152.8 0.2 2.5 2 0 0 2 2 2 1 Vps54-like protein Vps54_N PF10475.9 EDP41729.1 - 0.0017 17.7 5.1 0.0023 17.3 1.9 2.3 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex vATP-synt_E PF01991.18 EDP41729.1 - 0.034 13.5 0.7 0.14 11.5 0.4 2.1 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit Urease_gamma PF00547.18 EDP41729.1 - 0.83 10.0 3.0 0.82 10.0 0.1 2.6 3 0 0 3 3 3 0 Urease, gamma subunit RCC1 PF00415.18 EDP41730.1 - 2.6e-18 66.4 2.7 0.0073 16.9 0.7 5.3 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EDP41730.1 - 1.2e-10 41.7 0.3 1.6e-09 38.1 0.2 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EDP41730.1 - 3.3e-09 36.3 13.5 1.8e-05 24.4 0.1 6.1 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EDP41730.1 - 7.3e-09 35.9 0.0 0.00022 21.4 0.0 3.3 2 1 1 3 3 3 2 BTB/POZ domain Ank_5 PF13857.6 EDP41730.1 - 1.5e-07 31.6 0.2 2.9e-05 24.3 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDP41730.1 - 4.2e-07 30.5 0.0 8.7e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP41730.1 - 2.8e-06 27.2 0.4 0.017 15.6 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EDP41730.1 - 0.00039 20.8 0.4 0.58 10.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat PQQ_3 PF13570.6 EDP41730.1 - 0.23 12.0 1.2 20 5.8 0.1 3.3 3 0 0 3 3 3 0 PQQ-like domain CCAP PF11105.8 EDP41730.1 - 0.24 11.4 1.2 0.56 10.2 1.2 1.6 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a UPF0228 PF05727.11 EDP41731.1 - 0.11 12.3 0.3 0.26 11.1 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0228) YchF-GTPase_C PF06071.13 EDP41732.1 - 6.5e-33 112.8 0.0 1.6e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EDP41732.1 - 1.3e-17 63.9 0.0 3.2e-17 62.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP41732.1 - 2.9e-06 26.9 0.0 5.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EDP41732.1 - 0.094 13.3 1.2 9.7 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP41732.1 - 0.41 11.1 1.6 2.3 8.7 0.1 2.2 2 0 0 2 2 2 0 ABC transporter RNase_HII PF01351.18 EDP41733.1 - 2.4e-21 76.5 0.1 7.8e-16 58.5 0.0 2.3 2 0 0 2 2 2 2 Ribonuclease HII Cor1 PF04803.12 EDP41733.1 - 0.0034 17.6 0.1 0.0058 16.9 0.1 1.3 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region RNase_HII PF01351.18 EDP41734.1 - 1.2e-10 41.6 0.2 1.5e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 Ribonuclease HII DNA_pol_A_exo1 PF01612.20 EDP41735.1 - 1.8e-33 115.7 0.3 2.5e-33 115.3 0.3 1.2 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EDP41735.1 - 1.4e-17 64.1 0.0 4.1e-17 62.6 0.0 1.9 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 EDP41735.1 - 3.3e-09 36.6 0.3 6.5e-09 35.7 0.3 1.6 1 0 0 1 1 1 1 HRDC domain Nitroreductase PF00881.24 EDP41735.1 - 0.00014 21.9 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 Nitroreductase family ChaB PF06150.12 EDP41735.1 - 0.063 13.9 0.1 0.18 12.4 0.1 1.8 1 0 0 1 1 1 0 ChaB Cellulase PF00150.18 EDP41736.1 - 8.9e-10 38.4 6.6 1.8e-09 37.4 6.6 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF2613 PF11021.8 EDP41736.1 - 0.77 9.9 0.0 0.77 9.9 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) Cellulase PF00150.18 EDP41737.1 - 1.2e-13 51.2 5.2 1.9e-13 50.5 5.2 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF3701 PF12482.8 EDP41737.1 - 0.091 12.8 0.0 0.4 10.8 0.0 2.0 2 0 0 2 2 2 0 Phage integrase protein DEAD PF00270.29 EDP41738.1 - 1.3e-43 148.8 0.1 2.3e-43 148.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP41738.1 - 3.5e-32 111.0 0.1 1.2e-31 109.3 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP41738.1 - 0.00018 21.6 0.0 0.00036 20.6 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDP41738.1 - 0.00042 20.7 0.0 0.013 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP41738.1 - 0.025 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain UTP25 PF06862.12 EDP41738.1 - 0.037 12.8 0.0 1.2 7.8 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF3449 PF11931.8 EDP41739.1 - 7.5e-66 221.4 3.5 1.9e-63 213.6 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EDP41739.1 - 6.2e-23 81.1 1.5 3.2e-22 78.8 0.2 2.4 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 EDP41739.1 - 6.4e-08 32.7 2.9 0.00013 22.3 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type SF3a60_bindingd PF12108.8 EDP41739.1 - 7.4e-07 28.9 0.2 3e-06 27.0 0.1 2.0 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain zf-C2H2_jaz PF12171.8 EDP41739.1 - 6.5e-06 26.3 4.8 0.0005 20.3 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EDP41739.1 - 0.011 16.0 2.2 0.98 9.8 0.5 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) RPAP1_N PF08621.10 EDP41739.1 - 0.46 10.3 6.0 3.4 7.5 0.0 2.9 3 0 0 3 3 3 0 RPAP1-like, N-terminal Ribonuclease_T2 PF00445.18 EDP41742.1 - 9.5e-39 133.5 1.1 1.4e-38 132.9 1.1 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family TPR_7 PF13176.6 EDP41742.1 - 0.012 15.6 0.1 0.24 11.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat rve PF00665.26 EDP41743.1 - 8.4e-19 67.9 0.0 1.5e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 EDP41743.1 - 0.0016 18.5 1.2 0.0016 18.5 1.2 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 EDP41743.1 - 0.013 15.2 0.1 0.16 11.8 0.0 2.4 2 0 0 2 2 2 0 Integrase core domain 3-HAO PF06052.12 EDP41743.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase RNA_pol_Rpb1_5 PF04998.17 EDP41744.1 - 3.5e-82 275.8 0.0 9e-82 274.5 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDP41744.1 - 5.5e-64 215.4 0.1 1.1e-63 214.4 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDP41744.1 - 2.1e-35 122.0 0.0 4.4e-35 120.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDP41744.1 - 1.9e-20 72.8 0.0 6.6e-20 71.1 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 EDP41744.1 - 1.7e-15 57.2 0.6 2.4e-11 43.5 0.0 3.4 2 1 0 2 2 2 2 RNA polymerase Rpb1, domain 1 LcrG PF07216.12 EDP41744.1 - 0.035 14.0 0.3 0.14 12.1 0.2 2.1 2 0 0 2 2 2 0 LcrG protein ThiF PF00899.21 EDP41745.1 - 4.1e-39 134.4 0.0 8.5e-39 133.4 0.0 1.5 2 0 0 2 2 2 1 ThiF family DAO PF01266.24 EDP41745.1 - 0.0091 15.6 0.2 0.015 14.9 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 EDP41745.1 - 0.016 15.5 0.3 0.062 13.6 0.3 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 EDP41745.1 - 0.021 14.1 0.3 0.041 13.1 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EDP41745.1 - 0.089 12.4 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 6PF2K PF01591.18 EDP41746.1 - 8.9e-68 227.9 0.0 1.2e-67 227.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDP41746.1 - 3.9e-34 118.0 0.0 6.8e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDP41746.1 - 5.7e-08 33.0 0.3 1.2e-07 31.9 0.3 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDP41746.1 - 0.017 14.6 0.0 0.035 13.6 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 GBP PF02263.19 EDP41746.1 - 0.092 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain Peptidase_M24 PF00557.24 EDP41747.1 - 4.3e-41 140.9 0.0 6.2e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 PGA2 PF07543.12 EDP41747.1 - 0.031 14.2 6.8 0.16 11.9 7.1 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 CDC45 PF02724.14 EDP41747.1 - 1.6 6.9 7.5 2.1 6.6 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein GEN1_C PF18380.1 EDP41747.1 - 3.7 8.5 6.9 8.3 7.4 6.9 1.6 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Coilin_N PF15862.5 EDP41747.1 - 9.7 6.0 8.2 1.3e+02 2.3 8.1 2.2 2 0 0 2 2 2 0 Coilin N-terminus UQ_con PF00179.26 EDP41748.1 - 3.4e-31 107.8 0.0 3.5e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rhodanese PF00581.20 EDP41749.1 - 2.8e-18 66.4 0.0 4.3e-10 40.1 0.0 2.9 2 1 0 2 2 2 2 Rhodanese-like domain Arrestin_C PF02752.22 EDP41750.1 - 1.7e-14 54.4 0.7 1.2e-12 48.4 0.3 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDP41750.1 - 2.5e-13 50.3 0.1 8.7e-09 35.6 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EDP41750.1 - 0.00067 19.4 0.3 0.0069 16.1 0.0 2.4 3 0 0 3 3 3 1 Arrestin_N terminal like Mito_fiss_reg PF05308.11 EDP41750.1 - 0.0061 16.7 0.7 0.016 15.3 0.7 1.7 1 0 0 1 1 1 1 Mitochondrial fission regulator Nup188 PF10487.9 EDP41751.1 - 1.3e-29 102.8 0.0 1.2e-18 66.5 0.0 2.5 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Nup192 PF11894.8 EDP41751.1 - 0.00021 18.6 0.4 0.00021 18.6 0.4 2.7 4 0 0 4 4 4 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 COG6 PF06419.11 EDP41752.1 - 1.4e-57 195.3 0.0 1.6e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 B12-binding PF02310.19 EDP41752.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain Macro PF01661.21 EDP41753.1 - 1.1e-37 128.7 0.0 1.5e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Macro domain Methyltransf_23 PF13489.6 EDP41754.1 - 6.7e-11 42.3 0.0 9.9e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP41754.1 - 1.7e-08 35.1 0.0 3.7e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP41754.1 - 6e-07 30.1 0.0 2.2e-06 28.3 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDP41754.1 - 3.4e-05 23.4 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EDP41754.1 - 0.0023 18.6 0.0 0.0058 17.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP41754.1 - 0.0029 17.4 0.0 0.0053 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Nucleoporin_N PF08801.11 EDP41755.1 - 6.3e-12 45.0 0.0 9.1e-12 44.4 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDP41756.1 - 5e-76 256.7 0.4 9.3e-76 255.8 0.4 1.4 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Adeno_E1B_19K PF01691.16 EDP41756.1 - 0.079 12.5 0.4 0.42 10.2 0.3 2.3 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen DUF1682 PF07946.14 EDP41757.1 - 1.4e-57 195.3 0.0 1.8e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) CBP_BcsF PF11120.8 EDP41757.1 - 0.13 12.4 0.2 0.28 11.3 0.2 1.5 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF USP7_ICP0_bdg PF12436.8 EDP41758.1 - 3.5e-82 275.3 1.4 9.2e-82 274.0 0.8 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EDP41758.1 - 2.2e-64 217.0 4.5 3.3e-61 206.6 0.7 2.8 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EDP41758.1 - 4.5e-48 164.0 0.1 6.8e-48 163.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP41758.1 - 4.9e-24 85.5 0.0 1.3e-23 84.1 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EDP41758.1 - 8.6e-10 38.8 0.0 3e-08 33.8 0.0 2.9 2 1 0 2 2 2 1 MATH domain Chalcone_2 PF16035.5 EDP41759.1 - 9.1e-17 61.5 0.0 1.1e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Abhydrolase_1 PF00561.20 EDP41760.1 - 1.6e-12 47.6 0.2 3.1e-11 43.4 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP41760.1 - 1.1e-08 35.9 0.0 1.6e-08 35.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP41760.1 - 6.1e-07 28.9 0.0 8.4e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDP41760.1 - 9.8e-07 28.7 0.0 1.3e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Chlorophyllase2 PF12740.7 EDP41760.1 - 0.013 14.5 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 EDP41760.1 - 0.028 13.4 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Thioesterase PF00975.20 EDP41760.1 - 0.14 12.3 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Arrestin_N PF00339.29 EDP41761.1 - 6.9e-09 35.9 0.2 5.2e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Polysacc_deac_1 PF01522.21 EDP41762.1 - 3.8e-29 101.1 0.0 7.8e-29 100.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase TauD PF02668.16 EDP41763.1 - 1.9e-42 145.9 0.3 2.4e-42 145.6 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribonuclease PF00545.20 EDP41764.1 - 0.11 13.3 0.0 0.15 12.8 0.0 1.3 1 0 0 1 1 1 0 ribonuclease PI3_PI4_kinase PF00454.27 EDP41765.1 - 1.9e-33 116.3 0.1 4.2e-23 82.4 0.1 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EDP41765.1 - 5.6e-23 81.3 0.0 1.1e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EDP41765.1 - 0.042 13.2 0.3 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) cwf18 PF08315.12 EDP41766.1 - 2.1e-27 96.4 3.5 2.5e-27 96.2 3.5 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor zf-Mss51 PF13824.6 EDP41767.1 - 3.4e-22 78.3 1.2 5.8e-22 77.5 1.2 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 cobW PF02492.19 EDP41768.1 - 2.4e-33 115.2 0.0 3e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EDP41768.1 - 1.3e-05 24.3 1.1 5.6e-05 22.2 1.1 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EDP41768.1 - 0.003 17.6 0.0 0.0095 16.0 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EDP41768.1 - 0.023 15.3 0.0 0.06 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP41768.1 - 0.044 14.2 0.0 0.059 13.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.12 EDP41768.1 - 0.077 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein ABC_tran PF00005.27 EDP41768.1 - 0.091 13.3 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 EDP41768.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EDP41768.1 - 0.15 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 EDP41768.1 - 0.16 11.9 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MobB PF03205.14 EDP41768.1 - 0.46 10.4 2.3 2.8 7.9 0.0 2.5 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SelP_N PF04592.14 EDP41768.1 - 3.3 7.0 9.8 5.1 6.4 9.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Vma12 PF11712.8 EDP41769.1 - 8.3e-17 61.6 0.0 1.2e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase AFG1_ATPase PF03969.16 EDP41770.1 - 5.7e-89 298.5 1.0 1.2e-85 287.6 0.0 3.0 2 1 0 3 3 3 2 AFG1-like ATPase AAA_22 PF13401.6 EDP41770.1 - 6e-06 26.6 0.0 3.6e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDP41770.1 - 9.9e-05 22.8 0.1 0.00097 19.6 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EDP41770.1 - 0.0056 16.1 0.0 0.16 11.4 0.0 2.4 2 0 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 EDP41770.1 - 0.021 14.3 0.7 0.12 11.9 0.1 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 EDP41770.1 - 0.052 14.0 0.7 0.31 11.4 0.0 2.6 2 2 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDP41770.1 - 0.067 13.2 0.1 0.46 10.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EDP41770.1 - 0.11 12.9 0.1 1 9.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Mad3_BUB1_I PF08311.12 EDP41771.1 - 4.3e-42 143.0 0.3 7.4e-42 142.2 0.3 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EDP41771.1 - 1.3e-10 41.1 0.0 1.2e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP41771.1 - 0.039 13.2 0.0 0.22 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase Sde2_N_Ubi PF13019.6 EDP41771.1 - 0.12 12.2 0.8 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain Mad3_BUB1_I_2 PF17014.5 EDP41771.1 - 0.16 12.0 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein DNA_pol_phi PF04931.13 EDP41771.1 - 7.2 4.6 11.3 12 3.9 11.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Brix PF04427.18 EDP41772.1 - 1.2e-47 162.5 0.0 1.7e-47 162.1 0.0 1.1 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 EDP41772.1 - 1.5 8.0 27.5 0.15 11.4 22.2 1.8 2 0 0 2 2 2 0 BUD22 Cpn60_TCP1 PF00118.24 EDP41773.1 - 5.6e-150 500.2 12.0 6.7e-150 500.0 12.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 EDP41773.1 - 0.00014 21.4 0.1 0.00075 19.0 0.0 2.0 2 0 0 2 2 2 1 Telomere recombination Pkinase PF00069.25 EDP41774.1 - 4.8e-61 206.4 0.0 5.8e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP41774.1 - 2.5e-25 89.3 0.0 3.1e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP41774.1 - 3.6e-07 29.8 0.0 5.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDP41774.1 - 1e-05 25.0 0.3 1.8e-05 24.2 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EDP41774.1 - 0.0025 17.3 0.1 0.004 16.7 0.1 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EDP41774.1 - 0.0031 16.4 0.0 0.0046 15.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDP41774.1 - 0.05 13.5 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PACT_coil_coil PF10495.9 EDP41774.1 - 0.077 13.6 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein DUF2423 PF10338.9 EDP41775.1 - 8.8e-14 51.5 1.4 8.8e-14 51.5 1.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) Ank_2 PF12796.7 EDP41776.1 - 6e-32 110.1 2.2 7.8e-12 45.6 0.3 4.2 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP41776.1 - 1.8e-24 85.8 5.1 1.5e-08 35.0 0.1 5.9 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP41776.1 - 1.2e-17 62.1 3.8 0.057 14.0 0.1 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 EDP41776.1 - 1.2e-16 60.6 5.1 6e-05 23.2 0.2 6.4 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EDP41776.1 - 2.5e-13 49.8 7.1 0.0013 19.1 0.0 6.8 7 0 0 7 7 7 4 Ankyrin repeat GDPD PF03009.17 EDP41776.1 - 1e-10 41.8 0.0 1.8e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SPX PF03105.19 EDP41777.1 - 5.7e-07 29.8 0.0 5.7e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 SPX domain CRM1_C PF08767.11 EDP41778.1 - 5.1e-130 433.3 0.7 1.6e-128 428.4 0.0 3.2 2 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EDP41778.1 - 4.6e-40 137.1 4.0 7.2e-39 133.2 0.7 4.1 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EDP41778.1 - 4e-33 112.9 3.3 1e-32 111.6 3.3 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EDP41778.1 - 3.4e-31 107.1 2.8 9.2e-31 105.7 1.2 2.6 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EDP41778.1 - 5.4e-20 70.6 1.5 1.8e-19 68.9 1.5 2.0 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EDP41778.1 - 4.4e-14 52.1 0.4 4.4e-14 52.1 0.4 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Zn_peptidase PF04228.13 EDP41778.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Cnd1 PF12717.7 EDP41778.1 - 0.2 11.7 1.4 26 4.8 0.1 3.6 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 zf-C2H2 PF00096.26 EDP41780.1 - 9.6e-06 25.8 7.5 0.0016 18.8 1.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP41780.1 - 0.0026 18.4 8.3 0.013 16.2 0.9 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDP41780.1 - 0.0075 16.2 1.7 1.4 9.0 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP41780.1 - 0.81 10.2 6.7 1.2 9.7 0.9 2.7 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2HC_2 PF13913.6 EDP41780.1 - 1.1 9.3 8.3 0.24 11.3 2.7 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf_C2H2_ZHX PF18387.1 EDP41780.1 - 10 5.9 6.0 3 7.6 0.3 2.8 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain bZIP_1 PF00170.21 EDP41781.1 - 4.3e-05 23.5 10.2 9.4e-05 22.4 10.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDP41781.1 - 0.00062 19.8 9.0 0.0015 18.6 9.0 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EDP41781.1 - 0.08 13.5 6.7 0.19 12.3 6.7 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor GAT PF03127.14 EDP41781.1 - 0.086 13.2 0.5 0.22 11.8 0.5 1.7 1 0 0 1 1 1 0 GAT domain DUF4047 PF13256.6 EDP41781.1 - 0.09 13.0 0.5 0.16 12.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) Cdh1_DBD_1 PF18196.1 EDP41781.1 - 0.11 12.8 0.2 0.16 12.3 0.2 1.4 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Csm1_N PF18504.1 EDP41781.1 - 0.14 12.5 1.8 0.41 11.0 1.8 1.8 1 0 0 1 1 1 0 Csm1 N-terminal domain TMF_DNA_bd PF12329.8 EDP41781.1 - 0.17 11.9 1.8 0.34 10.9 1.8 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Glutaredoxin PF00462.24 EDP41782.1 - 3.1e-17 62.5 0.0 5e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin PDCD2_C PF04194.13 EDP41783.1 - 3.9e-36 124.7 7.1 3.5e-34 118.4 7.1 2.1 1 1 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Cwf_Cwc_15 PF04889.12 EDP41783.1 - 0.0058 16.4 9.3 0.18 11.5 7.2 2.2 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EDP41783.1 - 1 9.7 5.2 2 8.8 5.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MTHFR PF02219.17 EDP41784.1 - 5.9e-97 324.4 0.0 3.5e-96 321.9 0.0 1.9 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase AAA PF00004.29 EDP41785.1 - 7.3e-13 49.1 0.0 1.6e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDP41785.1 - 5.8e-10 39.8 0.2 2.4e-08 34.6 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDP41785.1 - 1e-08 35.5 0.0 2.1e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 EDP41785.1 - 4.6e-08 33.1 0.2 9.2e-08 32.1 0.2 1.4 1 0 0 1 1 1 1 AAA lid domain Cdc6_C PF09079.11 EDP41785.1 - 1.5e-05 24.9 0.0 4.5e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_19 PF13245.6 EDP41785.1 - 0.0037 17.6 1.0 0.012 15.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP41785.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Glyco_transf_22 PF03901.17 EDP41786.1 - 4.1e-66 223.9 25.1 5e-66 223.6 25.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Exo_endo_phos PF03372.23 EDP41787.1 - 3.3e-13 49.7 0.0 7.9e-13 48.5 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3392 PF11872.8 EDP41787.1 - 0.039 14.2 2.6 0.65 10.3 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3392) Ank_2 PF12796.7 EDP41789.1 - 4.9e-14 52.7 3.5 4.8e-08 33.5 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) TIG PF01833.24 EDP41789.1 - 4.9e-12 45.8 0.2 1.1e-10 41.5 0.3 2.8 2 0 0 2 2 2 1 IPT/TIG domain Ank PF00023.30 EDP41789.1 - 3.8e-11 42.9 5.0 2.1e-05 24.7 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EDP41789.1 - 5.7e-09 36.3 2.6 7.8e-08 32.7 1.4 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP41789.1 - 1.4e-08 34.3 2.8 0.0014 18.9 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EDP41789.1 - 3.2e-07 30.5 1.8 1.4e-06 28.4 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SDA1 PF05285.12 EDP41789.1 - 0.0011 18.4 2.2 0.0019 17.7 2.2 1.3 1 0 0 1 1 1 1 SDA1 DPBB_1 PF03330.18 EDP41790.1 - 1.3e-06 28.6 0.0 1.7e-06 28.2 0.0 1.3 1 1 0 1 1 1 1 Lytic transglycolase Cu_bind_like PF02298.17 EDP41790.1 - 0.018 15.0 0.1 0.026 14.5 0.1 1.2 1 0 0 1 1 1 0 Plastocyanin-like domain AAA_6 PF12774.7 EDP41790.1 - 0.14 11.1 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region RHD3 PF05879.12 EDP41791.1 - 3.9e-234 779.2 0.0 7.6e-234 778.2 0.0 1.4 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EDP41791.1 - 2.3e-05 24.4 0.0 5.5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 EDP41791.1 - 4.3e-05 22.9 0.1 7.6e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EDP41791.1 - 0.00016 21.8 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 EDP41791.1 - 0.0005 20.4 0.1 0.0021 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTF2 PF02136.20 EDP41792.1 - 1.8e-29 102.8 0.4 1.8e-29 102.8 0.4 1.9 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EDP41792.1 - 2.9e-09 36.6 0.0 6.1e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDP41792.1 - 0.0073 16.4 0.1 0.023 14.7 0.1 1.8 1 0 0 1 1 1 1 Limkain b1 PI3K_1B_p101 PF10486.9 EDP41792.1 - 0.0095 13.8 6.6 0.013 13.3 6.6 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SOBP PF15279.6 EDP41792.1 - 2.7 8.5 19.1 5.3 7.5 19.1 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein Dynamin_M PF01031.20 EDP41793.1 - 2.9e-101 338.5 0.0 4.2e-101 337.9 0.0 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EDP41793.1 - 2.7e-33 115.4 0.0 5.4e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EDP41793.1 - 1.4e-28 98.9 2.2 3.1e-28 97.8 2.2 1.6 1 0 0 1 1 1 1 Dynamin GTPase effector domain TatD_DNase PF01026.21 EDP41794.1 - 6.9e-32 110.8 0.0 7.8e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Cyclin_N PF00134.23 EDP41795.1 - 1.3e-43 147.8 0.8 3.7e-43 146.3 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDP41795.1 - 1.8e-26 92.5 0.3 3.1e-25 88.5 0.0 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain zf-HIT PF04438.16 EDP41796.1 - 1.4e-05 24.9 8.8 2e-05 24.4 8.8 1.3 1 0 0 1 1 1 1 HIT zinc finger FXMRP1_C_core PF12235.8 EDP41796.1 - 0.13 12.9 1.6 0.26 11.9 1.6 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Prenyltrans PF00432.21 EDP41799.1 - 4.8e-19 67.8 18.4 2.9e-06 26.9 0.0 6.1 4 2 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EDP41799.1 - 0.068 12.3 0.0 0.46 9.5 0.0 2.0 1 1 1 2 2 2 0 Squalene-hopene cyclase N-terminal domain PRIMA1 PF16101.5 EDP41799.1 - 1.4 8.9 7.8 0.25 11.4 3.7 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Thioredoxin PF00085.20 EDP41800.1 - 5e-27 93.9 0.0 1.9e-26 92.0 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EDP41800.1 - 0.00047 20.6 0.7 0.0032 17.9 0.2 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EDP41800.1 - 0.0039 16.6 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDP41800.1 - 0.0074 16.6 0.0 0.038 14.3 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 EDP41800.1 - 0.016 15.1 0.0 0.054 13.4 0.0 1.9 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_9 PF14595.6 EDP41800.1 - 0.026 14.3 0.0 0.026 14.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_7 PF13899.6 EDP41800.1 - 0.071 13.3 0.0 0.071 13.3 0.0 2.5 3 0 0 3 3 3 0 Thioredoxin-like Med3 PF11593.8 EDP41800.1 - 1.1 8.4 5.9 1.8 7.6 5.9 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PPR_2 PF13041.6 EDP41801.1 - 0.01 16.0 0.0 0.75 10.0 0.0 3.5 4 0 0 4 4 4 1 PPR repeat family TPR_19 PF14559.6 EDP41801.1 - 0.041 14.4 0.0 0.13 12.7 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3405 PF11885.8 EDP41802.1 - 1.4e-84 284.6 12.3 1.2e-53 182.5 1.6 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF3405) Amnionless PF14828.6 EDP41803.1 - 0.057 12.3 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Amnionless TraL PF07178.11 EDP41803.1 - 0.2 12.1 0.0 0.36 11.3 0.0 1.4 1 0 0 1 1 1 0 TraL protein PepSY_TM PF03929.16 EDP41803.1 - 0.3 10.7 1.6 0.39 10.4 0.0 1.8 2 0 0 2 2 2 0 PepSY-associated TM region Lactamase_B_2 PF12706.7 EDP41804.1 - 1.3e-18 67.3 0.0 2.1e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain STT3 PF02516.14 EDP41805.1 - 1.6e-134 449.5 40.6 4.9e-134 447.9 40.6 1.6 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit AAA PF00004.29 EDP41806.1 - 1e-59 200.7 0.0 2.2e-45 154.3 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDP41806.1 - 2.2e-09 37.9 1.4 0.0095 16.3 0.0 4.4 3 1 0 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 EDP41806.1 - 2.6e-07 30.5 0.0 0.0033 17.2 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDP41806.1 - 2.8e-07 30.6 0.0 0.0074 16.3 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EDP41806.1 - 0.00018 21.2 1.4 0.35 10.7 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain TsaE PF02367.17 EDP41806.1 - 0.00028 20.9 0.1 0.25 11.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EDP41806.1 - 0.00035 20.6 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EDP41806.1 - 0.00037 19.7 0.0 0.82 8.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDP41806.1 - 0.0006 20.1 0.4 0.057 13.7 0.1 3.4 3 1 1 4 4 3 1 AAA domain AAA_3 PF07726.11 EDP41806.1 - 0.00074 19.4 0.7 0.56 10.1 0.0 3.4 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EDP41806.1 - 0.0017 18.5 0.0 0.004 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EDP41806.1 - 0.0017 18.1 0.0 0.72 9.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 EDP41806.1 - 0.0021 18.6 0.0 0.17 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDP41806.1 - 0.0037 17.2 0.4 2.3 8.1 0.1 3.0 3 0 0 3 3 2 1 NACHT domain AAA_25 PF13481.6 EDP41806.1 - 0.0041 16.7 0.4 0.043 13.4 0.1 2.8 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EDP41806.1 - 0.0048 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 EDP41806.1 - 0.0068 16.6 0.0 0.36 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDP41806.1 - 0.0086 15.4 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_7 PF12775.7 EDP41806.1 - 0.01 15.3 0.0 0.071 12.6 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EDP41806.1 - 0.011 14.9 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EDP41806.1 - 0.011 15.9 0.0 0.39 11.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDP41806.1 - 0.012 15.0 0.5 0.047 13.1 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDP41806.1 - 0.013 15.8 0.0 0.089 13.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase FAM75 PF14650.6 EDP41806.1 - 0.017 14.7 18.0 0.03 13.9 18.0 1.3 1 0 0 1 1 1 0 FAM75 family NTPase_1 PF03266.15 EDP41806.1 - 0.031 14.2 0.1 7.4 6.4 0.0 2.4 2 0 0 2 2 2 0 NTPase TIP49 PF06068.13 EDP41806.1 - 0.032 13.4 0.0 0.063 12.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain MeaB PF03308.16 EDP41806.1 - 0.033 13.2 0.1 0.069 12.1 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Vps4_C PF09336.10 EDP41806.1 - 0.047 13.7 0.0 0.47 10.5 0.0 2.5 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain PhoH PF02562.16 EDP41806.1 - 0.058 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 EDP41806.1 - 0.076 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ldh_1_C PF02866.18 EDP41807.1 - 6.7e-48 162.8 0.2 1.2e-47 162.0 0.2 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDP41807.1 - 5.8e-44 149.6 0.1 1.2e-43 148.6 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDP41807.1 - 5.9e-06 25.5 0.0 8.1e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EDP41807.1 - 0.0018 18.2 0.1 0.0075 16.2 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EDP41807.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EDP41807.1 - 0.12 12.8 0.3 0.99 9.9 0.0 2.5 2 1 1 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain COG7 PF10191.9 EDP41808.1 - 2.5e-25 88.9 12.8 3e-16 58.9 9.8 3.4 3 1 0 3 3 3 3 Golgi complex component 7 (COG7) Snapin_Pallidin PF14712.6 EDP41808.1 - 0.034 14.5 0.5 0.94 9.9 0.4 2.6 2 0 0 2 2 2 0 Snapin/Pallidin DAHP_synth_1 PF00793.20 EDP41809.1 - 2.3e-96 321.9 0.0 2.7e-96 321.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family HEAT PF02985.22 EDP41811.1 - 4e-21 73.3 3.5 0.00048 20.2 0.0 9.8 9 0 0 9 9 9 4 HEAT repeat HEAT_EZ PF13513.6 EDP41811.1 - 2.4e-14 53.4 9.9 7.6e-09 35.9 0.0 6.9 6 1 1 7 7 7 2 HEAT-like repeat IBN_N PF03810.19 EDP41811.1 - 5.3e-09 35.9 3.1 8.7e-07 28.8 0.0 4.1 4 0 0 4 4 4 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EDP41811.1 - 7.3e-08 32.7 7.8 0.074 13.5 0.0 5.7 3 2 2 5 5 4 3 HEAT repeats MMS19_C PF12460.8 EDP41811.1 - 2.6e-05 23.5 3.9 0.11 11.6 0.0 3.9 4 1 0 4 4 4 3 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 EDP41811.1 - 0.0029 17.7 0.1 0.01 15.9 0.1 2.0 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EDP41811.1 - 0.017 15.2 7.2 3.1 8.0 0.1 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Proteasom_PSMB PF10508.9 EDP41811.1 - 0.019 13.5 0.2 8.3 4.8 0.0 3.0 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit SNF2_N PF00176.23 EDP41812.1 - 2e-71 240.6 0.1 4.6e-71 239.4 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 EDP41812.1 - 8.1e-39 132.2 0.5 3.6e-38 130.1 0.5 2.2 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 EDP41812.1 - 6.2e-29 101.0 2.7 6.2e-29 101.0 2.7 4.0 5 0 0 5 5 5 1 HAND Helicase_C PF00271.31 EDP41812.1 - 1.2e-20 73.9 0.0 5.4e-19 68.6 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EDP41812.1 - 1.5e-10 40.7 0.1 3.6e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EDP41812.1 - 1.3e-09 38.3 0.0 8.3e-09 35.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDP41812.1 - 2.3e-05 24.2 0.0 6.4e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DBINO PF13892.6 EDP41812.1 - 2.8e-05 24.5 1.7 2.8e-05 24.5 1.7 4.3 4 0 0 4 4 4 1 DNA-binding domain Myb_DNA-binding PF00249.31 EDP41812.1 - 0.0023 18.1 0.0 0.028 14.6 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 EDP41812.1 - 0.0046 16.2 0.4 0.012 14.8 0.4 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EDP41812.1 - 0.015 15.4 0.0 0.048 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF2407_C PF13373.6 EDP41814.1 - 3.5e-12 46.7 2.8 4.1e-11 43.2 2.8 2.5 1 1 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EDP41814.1 - 0.00054 20.5 0.1 0.16 12.5 0.0 3.1 2 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Lumazine_bd_2 PF12893.7 EDP41814.1 - 0.092 13.4 0.0 0.24 12.1 0.0 1.6 2 0 0 2 2 2 0 Putative lumazine-binding Peptidase_S8 PF00082.22 EDP41815.1 - 2.4e-40 138.7 1.4 2.4e-40 138.7 1.4 1.5 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 EDP41815.1 - 2.3e-23 82.0 0.1 6.2e-23 80.6 0.1 1.8 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EDP41815.1 - 0.0053 17.5 0.2 0.25 12.1 0.0 2.4 2 0 0 2 2 2 1 Peptidase S8 pro-domain Calreticulin PF00262.18 EDP41816.1 - 9.3e-167 554.5 8.1 1.2e-166 554.2 8.1 1.1 1 0 0 1 1 1 1 Calreticulin family CCB2_CCB4 PF11152.8 EDP41816.1 - 0.062 12.6 0.0 0.28 10.5 0.1 1.9 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 Lyase_1 PF00206.20 EDP41817.1 - 2.6e-96 322.7 0.0 3.7e-96 322.2 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EDP41817.1 - 2e-26 92.5 0.0 4.5e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DnaJ_C PF01556.18 EDP41818.1 - 1.4e-32 112.8 0.0 2e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDP41818.1 - 1.1e-23 83.2 0.4 1.6e-23 82.6 0.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDP41818.1 - 8.8e-13 48.4 22.9 1.5e-12 47.7 22.9 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDP41818.1 - 0.15 12.1 16.9 0.22 11.5 3.7 2.4 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Glyco_hydro_85 PF03644.13 EDP41820.1 - 2.5e-71 240.6 0.2 3.4e-71 240.1 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DUF5435 PF17503.2 EDP41820.1 - 0.028 14.2 0.8 0.05 13.3 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5435) Syntaxin_2 PF14523.6 EDP41821.1 - 1.9e-17 63.4 7.3 3.3e-17 62.7 0.1 3.0 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EDP41821.1 - 2.4e-09 37.0 2.0 3.4e-09 36.6 0.3 2.2 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 EDP41821.1 - 1.2e-07 31.7 12.4 1.6e-07 31.2 12.4 1.2 1 0 0 1 1 1 1 Syntaxin TMPIT PF07851.13 EDP41821.1 - 0.0089 15.3 1.0 0.0089 15.3 1.0 2.0 1 1 1 2 2 2 1 TMPIT-like protein MCPsignal PF00015.21 EDP41821.1 - 0.11 12.3 7.7 0.09 12.6 4.3 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Synaptobrevin PF00957.21 EDP41821.1 - 0.26 11.1 3.2 0.25 11.2 0.3 2.3 2 0 0 2 2 2 0 Synaptobrevin Ribosomal_S6 PF01250.17 EDP41821.1 - 0.57 10.5 2.6 8.1 6.8 0.0 3.4 2 2 2 4 4 4 0 Ribosomal protein S6 DUF1043 PF06295.12 EDP41821.1 - 1.7 8.6 11.6 4 7.5 0.2 3.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF1664 PF07889.12 EDP41821.1 - 3 7.9 10.3 1.1 9.4 3.6 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) TAF PF02969.17 EDP41822.1 - 1.5e-29 101.9 0.4 2.6e-29 101.2 0.4 1.4 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EDP41822.1 - 6.5e-05 23.3 0.4 0.00011 22.6 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDP41822.1 - 0.006 16.6 0.0 0.017 15.2 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit MOSC PF03473.17 EDP41822.1 - 0.042 13.9 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 MOSC domain THF_DHG_CYH PF00763.23 EDP41823.1 - 1.6e-26 92.9 0.0 3.1e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EDP41823.1 - 1.5e-13 50.4 0.0 1.1e-08 34.5 0.0 2.8 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain baeRF_family10 PF18854.1 EDP41823.1 - 0.01 16.0 0.0 0.026 14.8 0.0 1.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 SBP_bac_5 PF00496.22 EDP41823.1 - 0.056 12.4 0.1 0.082 11.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle RRM_1 PF00076.22 EDP41824.1 - 7.9e-12 44.8 0.2 3.4e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhoLip_ATPase_C PF16212.5 EDP41826.1 - 3.2e-49 167.9 20.1 3.2e-49 167.9 20.1 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDP41826.1 - 2e-18 65.8 4.8 5.3e-18 64.5 4.8 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EDP41826.1 - 1.7e-12 47.2 0.0 7.2e-11 42.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDP41826.1 - 4.3e-12 46.8 0.5 5.7e-07 30.0 0.6 2.8 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDP41826.1 - 8.6e-11 41.7 1.2 1.8e-09 37.4 0.0 3.4 3 2 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDP41826.1 - 7e-05 22.7 0.1 0.00018 21.4 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Vps35 PF03635.17 EDP41827.1 - 1.3e-292 972.8 0.0 1.5e-292 972.6 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Arm PF00514.23 EDP41827.1 - 0.085 12.9 0.0 0.29 11.2 0.0 2.1 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat Ribosomal_L18A PF01775.17 EDP41828.1 - 8.3e-53 177.6 1.3 1e-52 177.3 1.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Nup35_RRM_2 PF14605.6 EDP41829.1 - 3.1e-08 33.5 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 EDP41829.1 - 2.1e-07 30.7 0.0 0.015 15.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 EDP41829.1 - 1.8e-06 28.2 0.1 5.1e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 EDP41829.1 - 6e-06 26.0 3.3 1.1e-05 25.2 3.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP41829.1 - 4.2e-05 23.5 4.6 8e-05 22.6 4.6 1.5 1 0 0 1 1 1 1 Zinc finger domain SAP PF02037.27 EDP41829.1 - 0.071 12.9 0.1 0.17 11.7 0.1 1.7 1 0 0 1 1 1 0 SAP domain RRM_3 PF08777.11 EDP41829.1 - 0.087 12.9 0.1 4.2 7.5 0.0 3.1 3 0 0 3 3 3 0 RNA binding motif zf-CCCH_4 PF18044.1 EDP41829.1 - 0.64 9.9 4.1 1.2 9.0 4.1 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger ubiquitin PF00240.23 EDP41830.1 - 2.4e-34 116.9 0.5 3.7e-34 116.3 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 EDP41830.1 - 5.5e-29 99.8 12.2 9.9e-29 99.0 12.2 1.4 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 EDP41830.1 - 8.7e-16 57.5 0.6 8.7e-16 57.5 0.6 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDP41830.1 - 3.2e-05 24.3 0.3 0.00014 22.2 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDP41830.1 - 0.0035 17.2 0.1 0.011 15.7 0.1 1.8 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDP41830.1 - 0.0036 17.6 0.1 0.0059 16.9 0.1 1.4 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDP41830.1 - 0.0094 16.0 0.1 0.021 14.9 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EDP41830.1 - 0.025 14.6 1.1 6.3 6.9 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EDP41830.1 - 0.026 15.1 0.2 0.08 13.5 0.0 1.8 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain zf-C2H2_2 PF12756.7 EDP41831.1 - 4.5e-23 81.5 0.0 8.3e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF5017 PF16409.5 EDP41831.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5017) NOA36 PF06524.12 EDP41831.1 - 4.5 6.5 8.9 7 5.9 8.9 1.3 1 0 0 1 1 1 0 NOA36 protein NST1 PF13945.6 EDP41833.1 - 1e-25 91.0 8.3 3.1e-24 86.1 0.0 2.6 3 0 0 3 3 3 2 Salt tolerance down-regulator HC2 PF07382.11 EDP41834.1 - 0.00068 19.8 29.6 0.00068 19.8 29.6 2.1 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 Evr1_Alr PF04777.13 EDP41835.1 - 8.3e-26 90.4 0.3 1.7e-25 89.4 0.1 1.6 2 0 0 2 2 2 1 Erv1 / Alr family UCH PF00443.29 EDP41836.1 - 5.7e-65 219.4 0.0 7.2e-65 219.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP41836.1 - 1.1e-16 61.3 0.0 5e-16 59.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-MIZ PF02891.20 EDP41836.1 - 0.0023 17.6 0.0 0.0061 16.3 0.0 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Rhodanese PF00581.20 EDP41836.1 - 0.023 15.2 0.0 0.046 14.2 0.0 1.5 1 0 0 1 1 1 0 Rhodanese-like domain CRC_subunit PF08624.10 EDP41837.1 - 3.5e-46 157.0 0.0 1.9e-45 154.6 0.0 2.0 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit PPR_2 PF13041.6 EDP41838.1 - 6.3e-07 29.5 0.0 0.0001 22.4 0.0 3.6 3 1 0 3 3 3 1 PPR repeat family PPR_3 PF13812.6 EDP41838.1 - 0.042 13.9 0.0 1.2 9.3 0.0 2.5 1 1 1 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 EDP41838.1 - 0.15 12.4 0.1 1 9.8 0.0 2.6 3 0 0 3 3 3 0 PPR repeat eIF2_C PF09173.11 EDP41839.1 - 2.6e-36 123.8 0.2 6.8e-36 122.4 0.2 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EDP41839.1 - 2.3e-21 76.2 0.3 1.3e-20 73.8 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDP41839.1 - 2.1e-11 44.0 0.5 2.1e-11 44.0 0.5 2.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EDP41839.1 - 0.00063 19.7 0.2 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EDP41839.1 - 0.0067 16.5 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EDP41839.1 - 0.013 15.5 0.7 0.067 13.2 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EDP41839.1 - 0.072 13.1 0.1 0.2 11.7 0.1 1.9 1 1 0 1 1 1 0 Dynamin family Got1 PF04178.12 EDP41840.1 - 2.4e-15 56.9 11.8 7.7e-10 39.2 2.1 2.2 1 1 1 2 2 2 2 Got1/Sft2-like family PhaG_MnhG_YufB PF03334.14 EDP41840.1 - 0.076 13.3 6.9 0.14 12.5 6.9 1.5 1 0 0 1 1 1 0 Na+/H+ antiporter subunit DUF4396 PF14342.6 EDP41840.1 - 0.34 11.3 5.9 0.72 10.2 5.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4396) DUF2070 PF09843.9 EDP41840.1 - 4 5.6 6.3 4.7 5.4 6.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ATP_sub_h PF10775.9 EDP41841.1 - 3.3e-21 75.0 1.5 3.3e-21 75.0 1.5 2.0 2 1 0 2 2 2 1 ATP synthase complex subunit h DUF3519 PF12033.8 EDP41841.1 - 0.075 13.4 0.2 0.097 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) IATP PF04568.12 EDP41842.1 - 1.1e-11 45.0 1.9 1.1e-11 45.0 1.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP S8_pro-domain PF16470.5 EDP41842.1 - 0.0056 17.4 0.2 0.0073 17.0 0.2 1.2 1 0 0 1 1 1 1 Peptidase S8 pro-domain AAA_11 PF13086.6 EDP41843.1 - 6.9e-48 163.7 0.6 1.1e-47 163.0 0.6 1.3 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EDP41843.1 - 2.9e-45 154.4 0.0 8.3e-45 152.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDP41843.1 - 6.6e-16 59.0 0.3 2.4e-15 57.1 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP41843.1 - 1.1e-13 51.4 0.1 1.5e-10 41.1 0.1 3.0 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EDP41843.1 - 0.00045 19.8 0.1 0.00085 18.9 0.1 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDP41843.1 - 0.0093 16.4 1.9 0.047 14.1 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain ResIII PF04851.15 EDP41843.1 - 0.053 13.5 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.16 EDP41843.1 - 0.072 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein OTU PF02338.19 EDP41844.1 - 1.8e-09 38.2 0.0 3.4e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EDP41844.1 - 2.4e-05 23.9 0.1 0.048 13.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase C65 Otubain MTES_1575 PF18741.1 EDP41844.1 - 0.33 11.1 0.1 0.33 11.1 0.1 1.9 2 0 0 2 2 2 0 REase_MTES_1575 ANAPC1 PF12859.7 EDP41845.1 - 5.8e-17 62.5 2.7 8.4e-17 62.0 0.2 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 1 APC1_C PF18122.1 EDP41845.1 - 5.2e-08 33.0 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 EDP41845.1 - 0.0046 17.3 12.9 0.014 15.8 0.1 5.2 6 0 0 6 6 6 1 Proteasome/cyclosome repeat RrnaAD PF00398.20 EDP41846.1 - 1.6e-60 204.4 0.0 1e-59 201.8 0.0 1.9 1 1 1 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EDP41846.1 - 3.4e-08 34.1 0.0 6.9e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP41846.1 - 7.8e-07 29.7 0.0 1.8e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP41846.1 - 1.8e-05 25.4 0.0 3.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EDP41846.1 - 9.6e-05 22.2 0.0 0.00015 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EDP41846.1 - 0.00012 21.7 0.0 0.00025 20.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EDP41846.1 - 0.00053 19.4 0.0 0.00083 18.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 EDP41846.1 - 0.0013 18.4 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 EDP41846.1 - 0.0017 18.2 0.0 0.0027 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 EDP41846.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 EDP41846.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 EDP41846.1 - 0.022 14.1 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EDP41846.1 - 0.041 13.7 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EDP41846.1 - 0.078 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Met_10 PF02475.16 EDP41846.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Adaptin_N PF01602.20 EDP41847.1 - 2.2e-130 435.7 5.3 2.7e-130 435.4 5.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDP41847.1 - 2.8e-59 199.8 2.1 2.2e-56 190.4 0.2 3.2 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDP41847.1 - 1.1e-17 64.2 7.6 5.4e-05 23.5 0.0 6.8 3 2 4 7 7 7 5 HEAT repeats HEAT PF02985.22 EDP41847.1 - 1.6e-14 52.8 3.1 0.0035 17.5 0.0 7.7 7 0 0 7 7 7 3 HEAT repeat Cnd3 PF12719.7 EDP41847.1 - 3e-07 29.9 0.3 1.2e-05 24.6 0.1 2.6 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 EDP41847.1 - 6.2e-05 23.4 7.4 3.3 8.3 0.0 7.2 9 0 0 9 9 9 1 HEAT-like repeat RTP1_C1 PF10363.9 EDP41847.1 - 8.4e-05 22.7 0.7 2.7 8.2 0.0 5.0 4 1 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 EDP41847.1 - 0.0044 16.9 0.4 0.029 14.3 0.0 2.5 2 1 1 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal CLASP_N PF12348.8 EDP41847.1 - 0.0078 15.8 0.2 0.69 9.4 0.0 3.2 3 1 1 4 4 4 1 CLASP N terminal Cohesin_HEAT PF12765.7 EDP41847.1 - 0.048 14.0 0.5 4.3 7.7 0.0 3.6 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion HEAT_PBS PF03130.16 EDP41847.1 - 1.1 10.1 7.3 1.1e+02 3.9 0.1 4.9 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat DUF3074 PF11274.8 EDP41848.1 - 2.2e-41 141.8 0.0 3.7e-41 141.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Kelch_5 PF13854.6 EDP41849.1 - 3.5e-14 52.4 7.9 3.9e-07 29.9 0.1 5.5 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EDP41849.1 - 6.1e-10 39.0 3.9 0.00011 22.1 0.0 5.7 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EDP41849.1 - 6.3e-09 35.9 11.4 0.0079 16.5 0.1 4.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EDP41849.1 - 0.00049 20.3 6.9 0.0056 16.9 0.2 4.7 4 1 1 5 5 5 1 Kelch motif Kelch_2 PF07646.15 EDP41849.1 - 0.0006 19.7 0.2 0.0045 16.9 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 EDP41849.1 - 0.0017 17.9 1.9 0.032 13.8 0.2 3.5 3 0 0 3 3 3 1 Kelch motif CD99L2 PF12301.8 EDP41849.1 - 0.05 13.9 9.7 0.13 12.6 9.7 1.6 1 0 0 1 1 1 0 CD99 antigen like protein 2 HIG_1_N PF04588.13 EDP41849.1 - 0.13 12.5 0.6 0.31 11.3 0.2 1.8 2 0 0 2 2 2 0 Hypoxia induced protein conserved region PorA PF11271.8 EDP41849.1 - 0.65 9.2 6.6 27 3.9 0.0 3.0 3 0 0 3 3 3 0 Porin PorA Aldose_epim PF01263.20 EDP41850.1 - 1.3e-11 44.4 0.0 2.3e-11 43.6 0.0 1.4 1 1 0 1 1 1 1 Aldose 1-epimerase ZU5 PF00791.20 EDP41850.1 - 0.022 15.1 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 ZU5 domain PMT PF02366.18 EDP41851.1 - 3.5e-80 269.1 15.4 3.5e-80 269.1 15.4 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDP41851.1 - 5.6e-59 199.1 4.8 5.6e-59 199.1 4.8 2.7 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDP41851.1 - 1.9e-17 63.7 1.8 7.5e-17 61.8 0.7 2.0 1 1 1 2 2 2 2 MIR domain PMT_2 PF13231.6 EDP41851.1 - 2.5e-05 24.6 12.3 2.5e-05 24.6 12.3 2.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Stonin2_N PF12016.8 EDP41852.1 - 0.082 12.3 2.8 0.099 12.1 2.8 1.0 1 0 0 1 1 1 0 Stonin 2 GMC_oxred_N PF00732.19 EDP41853.1 - 1e-36 126.8 0.2 4.1e-36 124.9 0.1 1.9 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDP41853.1 - 1.1e-22 81.1 0.0 3.5e-22 79.5 0.0 1.8 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDP41853.1 - 4.7e-12 45.7 3.6 4.2e-05 22.8 1.7 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EDP41853.1 - 3.3e-08 33.5 7.8 4.5e-07 29.8 7.8 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDP41853.1 - 0.00036 19.9 0.3 0.00085 18.7 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EDP41853.1 - 0.00054 19.3 0.4 0.00089 18.6 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDP41853.1 - 0.0012 18.1 0.6 0.0028 16.9 0.6 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EDP41853.1 - 0.0016 18.6 2.3 0.0049 17.1 2.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDP41853.1 - 0.032 14.8 0.5 0.23 12.0 0.4 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDP41853.1 - 0.083 11.9 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EDP41853.1 - 0.12 11.7 4.4 1.9 7.8 4.6 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 EDP41853.1 - 0.23 11.0 3.4 0.44 10.1 3.4 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.22 EDP41853.1 - 0.28 10.2 0.4 0.48 9.4 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EDP41853.1 - 0.68 8.6 2.7 0.51 9.0 1.3 1.5 2 0 0 2 2 2 0 HI0933-like protein Bin3 PF06859.12 EDP41854.1 - 9.9e-23 80.8 0.0 1.5e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 EDP41854.1 - 2.4e-07 30.7 0.0 3.1e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP41854.1 - 0.00012 21.9 0.0 0.014 15.2 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EDP41854.1 - 0.00012 22.7 0.0 0.017 15.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP41854.1 - 0.0053 17.5 0.0 3.6 8.4 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain RNA_pol PF00940.19 EDP41855.1 - 1.4e-176 587.4 0.0 2.1e-176 586.9 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EDP41855.1 - 8.3e-97 324.6 2.1 8.3e-97 324.6 2.1 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal TPX2_importin PF12214.8 EDP41855.1 - 0.15 12.2 5.1 0.19 11.9 3.8 1.8 1 1 0 1 1 1 0 Cell cycle regulated microtubule associated protein PPR_2 PF13041.6 EDP41855.1 - 0.15 12.3 0.1 10 6.4 0.0 2.5 2 0 0 2 2 2 0 PPR repeat family Sod_Fe_C PF02777.18 EDP41856.1 - 3.8e-35 120.1 0.1 6.6e-35 119.4 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDP41856.1 - 1.4e-30 105.6 0.5 1.4e-30 105.6 0.5 1.9 2 1 1 3 3 3 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SET PF00856.28 EDP41858.1 - 4.7e-19 69.4 0.3 4.7e-19 69.4 0.3 3.5 2 2 0 2 2 2 1 SET domain AWS PF17907.1 EDP41858.1 - 1.1e-12 47.7 6.4 1.1e-12 47.7 6.4 2.5 2 0 0 2 2 2 1 AWS domain SRI PF08236.11 EDP41858.1 - 1.9e-10 40.8 11.5 1.2e-05 25.4 0.1 3.2 3 0 0 3 3 3 2 SRI (Set2 Rpb1 interacting) domain Med26 PF08711.11 EDP41858.1 - 0.029 14.4 0.1 0.11 12.5 0.1 2.1 1 0 0 1 1 1 0 TFIIS helical bundle-like domain WDCP PF15390.6 EDP41858.1 - 7.5 4.8 13.2 12 4.1 13.2 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family XPA_C PF05181.12 EDP41859.1 - 2.1e-23 82.0 1.1 3.4e-23 81.3 1.1 1.4 1 0 0 1 1 1 1 XPA protein C-terminus Zn-ribbon_8 PF09723.10 EDP41859.1 - 6.6 6.9 8.6 6.2 7.0 0.1 2.8 2 1 1 3 3 3 0 Zinc ribbon domain PD40 PF07676.12 EDP41861.1 - 0.039 13.9 1.6 2.5 8.2 0.0 3.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 EDP41861.1 - 0.053 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF5551 PF17705.1 EDP41861.1 - 0.068 12.8 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5551) Proteasome_A_N PF10584.9 EDP41861.1 - 0.077 12.7 3.7 0.15 11.8 0.0 3.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Ge1_WD40 PF16529.5 EDP41861.1 - 0.15 11.0 0.0 2.1 7.3 0.0 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 EDP41861.1 - 0.64 11.0 2.6 12 6.9 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat FA_desaturase PF00487.24 EDP41862.1 - 4.7e-25 88.9 25.7 4.7e-25 88.9 25.7 1.7 1 1 1 2 2 2 1 Fatty acid desaturase Mus7 PF09462.10 EDP41863.1 - 3.1e-74 250.9 0.0 5.2e-74 250.2 0.0 1.3 1 0 0 1 1 1 1 Mus7/MMS22 family Urb2 PF10441.9 EDP41863.1 - 0.0019 18.2 0.1 0.16 11.8 0.1 2.4 1 1 1 2 2 2 2 Urb2/Npa2 family RhoGEF PF00621.20 EDP41864.1 - 2.6e-20 73.4 0.8 7.5e-19 68.7 0.0 2.5 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EDP41864.1 - 4e-18 65.3 10.5 9.2e-18 64.1 10.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EDP41864.1 - 0.02 15.4 1.7 0.2 12.2 0.4 2.9 2 1 0 2 2 2 0 PH domain Furin-like_2 PF15913.5 EDP41864.1 - 0.92 9.7 9.3 1.8 8.7 9.3 1.4 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich Collagen PF01391.18 EDP41865.1 - 0.41 10.4 11.2 0.69 9.7 11.2 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) CTD_bind PF04818.13 EDP41866.1 - 1.3e-06 29.1 0.0 4.8e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. NR_Repeat PF14046.6 EDP41866.1 - 0.39 10.9 1.8 0.65 10.2 0.7 1.9 2 0 0 2 2 2 0 Nuclear receptor repeat SRP9-21 PF05486.12 EDP41867.1 - 0.0017 18.7 7.1 0.02 15.2 0.0 3.1 2 1 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Ribosomal_L24e PF01246.20 EDP41868.1 - 5.2e-07 29.8 0.9 1.1e-06 28.7 0.9 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e HAGH_C PF16123.5 EDP41868.1 - 0.031 14.8 2.5 0.078 13.5 2.4 1.9 1 1 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus R2K_3 PF14243.6 EDP41868.1 - 0.072 13.1 0.7 0.082 12.9 0.7 1.2 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 SEA PF01390.20 EDP41868.1 - 0.16 12.0 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 SEA domain WD40 PF00400.32 EDP41869.1 - 1.3e-19 70.2 10.9 0.00038 21.2 0.0 5.9 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41869.1 - 3.3e-06 27.3 0.0 0.51 10.7 0.0 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP41869.1 - 0.0085 14.8 1.9 1.9 7.1 0.0 3.2 3 1 1 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EDP41869.1 - 0.018 14.4 0.0 1.5 8.0 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain PRP4 PF08799.11 EDP41870.1 - 4.3e-10 39.0 2.0 9.9e-10 37.8 2.0 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.6 EDP41870.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal tRNA-synt_2d PF01409.20 EDP41871.1 - 2.2e-85 286.1 0.0 2.9e-85 285.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EDP41871.1 - 3.5e-10 40.0 0.0 1.8e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EDP41871.1 - 1.3e-07 31.3 0.0 0.00064 19.2 0.0 2.5 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EDP41871.1 - 0.00069 18.8 0.6 0.0044 16.2 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 EDP41871.1 - 0.87 9.6 3.0 2.8 8.0 3.0 1.9 1 1 0 1 1 1 0 PheRS DNA binding domain 2 Peptidase_M3 PF01432.20 EDP41872.1 - 8e-131 437.4 0.0 9.8e-131 437.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 MFS_1 PF07690.16 EDP41874.1 - 4.2e-44 150.9 30.8 5.3e-44 150.6 30.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP41874.1 - 2.2e-12 46.6 13.1 2.2e-12 46.6 13.1 2.7 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EDP41874.1 - 5.5e-06 25.1 1.7 7.8e-06 24.6 1.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EDP41874.1 - 8e-05 21.1 1.1 8e-05 21.1 1.1 1.8 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EDP41874.1 - 0.0083 15.0 5.6 0.0083 15.0 5.6 3.6 3 1 1 4 4 4 2 MFS_1 like family MFS_3 PF05977.13 EDP41874.1 - 0.17 10.2 4.8 0.12 10.8 2.3 1.9 2 1 0 2 2 2 0 Transmembrane secretion effector MFS_1 PF07690.16 EDP41875.1 - 2.2e-20 72.9 19.3 4.8e-11 42.2 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipase_3 PF01764.25 EDP41876.1 - 1.2e-27 96.5 0.0 1.6e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EDP41876.1 - 2.5e-06 27.2 0.0 1.8e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EDP41876.1 - 0.00068 19.0 0.0 0.00097 18.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDP41876.1 - 0.009 16.6 0.1 0.013 16.1 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EDP41876.1 - 0.018 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_1 PF00561.20 EDP41876.1 - 0.025 14.3 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 EDP41876.1 - 0.032 12.9 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 EDP41876.1 - 0.065 12.9 0.0 0.15 11.7 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EDP41876.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF676 PF05057.14 EDP41876.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 EDP41876.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.16 EDP41877.1 - 1.3e-30 106.6 37.7 2.3e-29 102.4 32.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_5_2 PF16079.5 EDP41877.1 - 5.1 7.5 11.9 0.19 12.1 0.8 3.5 3 1 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V FAD_binding_7 PF03441.14 EDP41878.1 - 2.8e-77 258.8 4.9 4.3e-77 258.2 4.9 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase GMC_oxred_N PF00732.19 EDP41879.1 - 8.8e-48 163.2 0.3 1.2e-47 162.8 0.3 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDP41879.1 - 7.8e-28 97.8 0.0 1.4e-27 97.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDP41879.1 - 7.1e-07 28.6 0.6 0.0015 17.7 0.2 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDP41879.1 - 0.00019 21.6 1.8 0.00036 20.7 0.4 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDP41879.1 - 0.0057 15.9 0.1 0.014 14.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDP41879.1 - 0.032 13.8 1.0 0.86 9.1 0.3 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDP41879.1 - 0.038 13.0 0.1 0.055 12.5 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 EDP41879.1 - 0.039 12.7 0.3 1.7 7.2 0.1 2.2 2 0 0 2 2 2 0 HI0933-like protein DUF1188 PF06690.11 EDP41879.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Asp PF00026.23 EDP41880.1 - 2.7e-13 50.1 0.0 3e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EDP41880.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal ADH_zinc_N PF00107.26 EDP41882.1 - 2.5e-16 59.8 0.1 3.7e-16 59.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP41882.1 - 6.6e-16 58.2 0.7 3.2e-15 56.0 0.2 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDP41882.1 - 2.8e-05 25.2 0.0 4.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Asp PF00026.23 EDP41884.1 - 2.4e-32 112.6 0.0 2.1e-31 109.5 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDP41884.1 - 0.00056 20.2 0.0 0.082 13.1 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDP41884.1 - 0.0013 19.3 0.0 0.54 10.9 0.0 2.8 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP41884.1 - 0.0054 17.3 0.0 1.3 9.6 0.0 2.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDP41884.1 - 0.061 13.1 0.0 0.57 10.0 0.0 2.2 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal DUF5635 PF18685.1 EDP41884.1 - 0.21 11.6 0.3 0.4 10.7 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5635) His_Phos_2 PF00328.22 EDP41886.1 - 2e-05 24.1 0.0 0.00096 18.6 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Metallophos PF00149.28 EDP41887.1 - 5.2e-11 43.4 1.2 8.1e-11 42.8 1.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Amidase PF01425.21 EDP41888.1 - 1.6e-89 301.0 0.0 2e-89 300.6 0.0 1.1 1 0 0 1 1 1 1 Amidase MotCF PF09158.10 EDP41889.1 - 0.083 13.0 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage T4 MotA, C-terminal EVE PF01878.18 EDP41891.1 - 3.4e-38 130.9 0.0 6.6e-38 130.0 0.0 1.4 1 1 0 1 1 1 1 EVE domain DUF1891 PF09004.10 EDP41891.1 - 0.15 11.7 0.1 0.28 10.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1891) Pkinase PF00069.25 EDP41892.1 - 3.5e-53 180.6 0.0 2.5e-46 158.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP41892.1 - 2.4e-23 82.7 0.0 1e-19 70.9 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EDP41892.1 - 0.00016 21.1 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDP41892.1 - 0.00045 19.6 0.1 0.0024 17.2 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDP41892.1 - 0.048 12.4 0.0 0.076 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EDP41892.1 - 0.049 13.6 0.1 0.12 12.3 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family RasGAP PF00616.19 EDP41893.1 - 3.2e-40 138.0 0.6 1.1e-39 136.3 0.0 2.2 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EDP41893.1 - 1.9e-10 41.0 1.3 4.7e-10 39.7 1.3 1.7 1 0 0 1 1 1 1 RasGAP C-terminus DUF3196 PF11428.8 EDP41893.1 - 0.52 9.8 5.7 1.3 8.5 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3196) Ribosomal_L13e PF01294.18 EDP41894.1 - 1.4e-72 243.3 4.5 1.4e-72 243.3 4.5 1.4 2 0 0 2 2 2 1 Ribosomal protein L13e Peptidase_M76 PF09768.9 EDP41895.1 - 1.9e-67 226.3 0.1 2.3e-67 226.0 0.1 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EDP41895.1 - 0.034 14.0 2.8 0.064 13.1 1.2 1.9 1 1 1 2 2 2 0 SprT-like family Dicty_spore_N PF04562.12 EDP41895.1 - 0.11 13.2 1.2 4.3 8.1 0.7 2.3 1 1 1 2 2 2 0 Dictyostelium spore coat protein, N terminus Lebercilin PF15619.6 EDP41896.1 - 0.0039 16.9 4.7 0.005 16.5 4.7 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease V-SNARE_C PF12352.8 EDP41896.1 - 0.026 14.8 1.6 0.84 10.0 0.2 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus MutS_V PF00488.21 EDP41897.1 - 2.1e-79 266.0 0.2 4.2e-79 265.0 0.0 1.6 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EDP41897.1 - 4.5e-31 108.6 1.5 5.5e-31 108.3 0.1 1.9 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EDP41897.1 - 2.6e-16 59.8 0.1 8.5e-16 58.1 0.1 2.0 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EDP41897.1 - 1.1e-15 58.1 0.3 6e-15 55.7 0.1 2.2 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.20 EDP41897.1 - 1.3e-15 57.6 0.0 2.4e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain I Phage_fiber_2 PF03406.13 EDP41897.1 - 0.088 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Phage tail fibre repeat ING PF12998.7 EDP41898.1 - 2.1e-09 37.9 1.5 3.8e-09 37.1 1.5 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDP41898.1 - 0.00012 21.9 11.1 0.00025 20.9 11.1 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.6 EDP41898.1 - 0.014 15.6 0.4 0.035 14.3 0.4 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDP41898.1 - 0.05 13.9 2.2 0.17 12.2 2.2 1.9 1 0 0 1 1 1 0 PHD-like zinc-binding domain PLDc_2 PF13091.6 EDP41899.1 - 3.3e-12 46.5 0.0 2.2e-06 27.6 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDP41899.1 - 2.9e-09 36.7 1.3 0.0041 17.2 0.0 3.1 2 1 0 2 2 2 2 Phospholipase D Active site motif Gcd10p PF04189.13 EDP41901.1 - 3.9e-39 134.5 0.2 4e-23 82.0 0.0 2.4 2 1 1 3 3 3 2 Gcd10p family DUF5572 PF17733.1 EDP41902.1 - 7.8e-19 67.3 0.9 1.2e-18 66.6 0.9 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Mpp10 PF04006.12 EDP41903.1 - 7.7e-103 345.0 97.5 5.1e-100 335.7 97.5 2.7 1 1 0 1 1 1 1 Mpp10 protein Aminotran_3 PF00202.21 EDP41904.1 - 1.7e-41 142.2 0.0 6.9e-19 67.8 0.0 3.2 2 1 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 EDP41904.1 - 0.00011 22.1 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain TPR_1 PF00515.28 EDP41907.1 - 1.9e-30 103.4 13.4 7.3e-06 25.6 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EDP41907.1 - 2.2e-23 80.5 3.0 5e-05 23.2 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDP41907.1 - 2.5e-23 80.2 18.6 0.0012 18.8 0.1 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDP41907.1 - 7.1e-16 57.6 20.3 0.002 18.8 0.1 8.1 5 1 3 8 8 8 5 Tetratricopeptide repeat ANAPC8 PF04049.13 EDP41907.1 - 1.8e-15 57.2 1.2 1.6e-14 54.2 1.2 2.2 1 1 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_11 PF13414.6 EDP41907.1 - 4.5e-14 51.9 2.2 0.0011 18.5 0.0 5.2 2 1 3 5 5 5 2 TPR repeat TPR_15 PF13429.6 EDP41907.1 - 9.1e-12 44.8 8.0 0.00046 19.5 0.1 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP41907.1 - 2.1e-11 43.3 8.2 0.031 14.6 0.0 7.5 8 1 1 9 9 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDP41907.1 - 6.2e-10 39.4 8.3 0.0032 17.9 0.0 5.7 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDP41907.1 - 6.4e-10 39.5 14.7 0.00015 22.3 0.3 5.4 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP41907.1 - 7.8e-10 38.9 18.1 0.00011 22.5 0.3 5.5 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP41907.1 - 1.3e-09 37.4 11.7 0.0009 19.1 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP41907.1 - 1.8e-08 34.5 12.8 0.0064 16.7 0.2 4.5 4 1 1 5 5 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDP41907.1 - 8.9e-08 32.2 19.9 0.00011 22.3 0.4 5.0 3 1 2 6 6 5 3 Tetratricopeptide repeat ChAPs PF09295.10 EDP41907.1 - 4.8e-05 22.5 0.1 0.00031 19.9 0.0 2.0 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.6 EDP41907.1 - 4.9e-05 23.7 3.5 4.6 8.1 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat BTAD PF03704.17 EDP41907.1 - 0.038 14.4 5.9 0.15 12.5 2.5 3.0 1 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EDP41907.1 - 5.8 6.9 12.2 2 8.4 0.0 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat FHA PF00498.26 EDP41908.1 - 1.3e-16 60.7 0.5 4.3e-16 59.0 0.0 2.2 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EDP41908.1 - 7.7e-05 22.9 0.0 0.00035 20.8 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Jnk-SapK_ap_N PF09744.9 EDP41908.1 - 0.0057 16.9 10.2 0.026 14.8 4.0 2.3 2 0 0 2 2 2 2 JNK_SAPK-associated protein-1 DUF1843 PF08898.10 EDP41908.1 - 0.21 12.1 2.9 1 9.9 2.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1843) Mer2 PF09074.10 EDP41908.1 - 1.2 9.0 10.7 4.5 7.0 0.9 2.3 2 0 0 2 2 2 0 Mer2 Ribosomal_L38e PF01781.18 EDP41909.1 - 5.2e-33 113.0 3.0 5.9e-33 112.8 3.0 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Ribosomal_S11 PF00411.19 EDP41910.1 - 5.8e-47 158.6 1.1 7e-47 158.4 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CS PF04969.16 EDP41911.1 - 2.8e-17 63.5 0.1 7.4e-17 62.1 0.0 1.7 2 0 0 2 2 2 1 CS domain SNF2_N PF00176.23 EDP41912.1 - 1.2e-45 155.8 0.0 2.1e-45 154.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EDP41912.1 - 6.3e-11 42.6 0.0 1e-10 41.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDP41912.1 - 5e-08 32.9 0.0 7.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EDP41912.1 - 0.00056 19.7 0.0 0.0018 18.0 0.0 1.7 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2439 PF10382.9 EDP41912.1 - 0.088 13.2 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) Bac_surface_Ag PF01103.23 EDP41913.1 - 2.9e-23 82.9 0.0 8.9e-18 64.8 0.0 2.1 1 1 1 2 2 2 2 Surface antigen RNA_pol_Rbc25 PF08292.12 EDP41914.1 - 3.9e-36 124.1 0.0 5.5e-36 123.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EDP41914.1 - 9.8e-21 73.9 0.1 7e-20 71.2 0.1 2.1 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RhoGAP PF00620.27 EDP41915.1 - 7.3e-17 61.6 0.8 1.1e-16 61.0 0.8 1.3 1 0 0 1 1 1 1 RhoGAP domain Vps8 PF12816.7 EDP41916.1 - 5.4e-48 163.1 1.7 6.5e-48 162.9 0.4 1.9 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 ANAPC4_WD40 PF12894.7 EDP41916.1 - 0.018 15.3 0.0 0.16 12.3 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDP41916.1 - 0.025 15.4 0.1 0.16 12.9 0.1 2.5 1 0 0 1 1 1 0 WD domain, G-beta repeat MdcE PF06833.11 EDP41916.1 - 0.37 10.2 1.0 0.66 9.4 0.1 1.8 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Peptidase_M41 PF01434.18 EDP41917.1 - 5.3e-61 205.8 0.0 1.6e-60 204.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EDP41917.1 - 2.9e-42 144.2 0.0 5.8e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP41917.1 - 9.4e-11 41.3 0.1 1.9e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EDP41917.1 - 1.4e-10 41.5 0.0 5e-10 39.7 0.0 2.0 2 0 0 2 2 2 1 FtsH Extracellular TIP49 PF06068.13 EDP41917.1 - 0.0083 15.4 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EDP41917.1 - 0.01 16.1 0.0 0.94 9.7 0.1 2.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EDP41917.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDP41917.1 - 0.015 15.8 1.2 3.6 8.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP41917.1 - 0.021 15.2 1.2 0.13 12.7 0.2 2.8 3 1 1 4 4 4 0 AAA ATPase domain AAA_5 PF07728.14 EDP41917.1 - 0.03 14.3 0.0 0.12 12.3 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EDP41917.1 - 0.057 13.8 0.7 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain ARID PF01388.21 EDP41918.1 - 6.3e-06 26.8 0.0 2.1e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 EDP41918.1 - 0.0086 15.4 0.2 1.1 8.4 0.0 2.4 2 0 0 2 2 2 2 SWI/SNF-like complex subunit BAF250/Osa RPN1_C PF18051.1 EDP41919.1 - 1.7e-25 88.8 0.0 2.3e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal RPN1_RPN2_N PF17781.1 EDP41920.1 - 1.5e-114 382.6 1.7 2.9e-114 381.6 1.5 1.6 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 EDP41920.1 - 7.6e-18 64.0 14.1 3.3e-07 30.4 0.0 7.8 8 0 0 8 8 8 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDP41920.1 - 0.00021 21.6 0.2 1 9.8 0.0 3.8 3 1 1 4 4 4 2 HEAT repeats IFRD PF05004.13 EDP41920.1 - 0.22 10.6 2.2 3.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) HhH-GPD PF00730.25 EDP41921.1 - 6.1e-14 52.4 0.0 1.1e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH_5 PF14520.6 EDP41921.1 - 0.064 13.9 0.0 0.17 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH PF00633.23 EDP41921.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Aa_trans PF01490.18 EDP41923.1 - 8.4e-55 186.1 20.3 1.1e-54 185.7 20.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Nsp1_C PF05064.13 EDP41924.1 - 6.1e-32 109.9 0.2 1.1e-31 109.0 0.2 1.4 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EDP41924.1 - 1.3e-05 25.9 119.1 0.0013 19.5 25.3 5.3 1 1 2 3 3 3 2 Nucleoporin FG repeat region bMG5 PF17972.1 EDP41924.1 - 0.0012 19.2 5.7 14 6.1 0.0 5.7 2 1 3 5 5 5 1 Bacterial Alpha-2-macroglobulin MG5 domain LTXXQ PF07813.12 EDP41924.1 - 0.0055 17.4 7.5 0.012 16.3 7.5 1.5 1 0 0 1 1 1 1 LTXXQ motif family protein Lipoprotein_7 PF01540.16 EDP41924.1 - 0.04 13.2 0.1 0.058 12.7 0.1 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein GAS PF13851.6 EDP41924.1 - 0.12 11.7 3.9 0.22 10.9 3.9 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.6 EDP41924.1 - 0.15 10.7 2.0 0.2 10.2 1.6 1.4 1 1 0 1 1 1 0 AAA domain Tropomyosin PF00261.20 EDP41924.1 - 0.27 10.6 3.6 0.4 10.0 3.6 1.2 1 0 0 1 1 1 0 Tropomyosin ABC_tran_CTD PF16326.5 EDP41924.1 - 0.37 11.1 2.5 0.95 9.8 2.5 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain Nucleoporin_FG2 PF15967.5 EDP41924.1 - 0.38 9.2 82.1 0.0082 14.7 23.3 4.7 2 1 1 4 4 4 0 Nucleoporin FG repeated region Proteasome PF00227.26 EDP41925.1 - 1.9e-28 99.3 0.0 2.2e-28 99.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Peptidase_S9 PF00326.21 EDP41926.1 - 1.5e-49 168.4 0.2 2.4e-49 167.7 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 EDP41926.1 - 0.097 11.3 0.0 4.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DNA_pol3_delta2 PF13177.6 EDP41927.1 - 4.3e-09 36.4 0.1 6.7e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EDP41927.1 - 0.00023 21.5 0.4 0.00084 19.7 0.0 2.1 3 1 0 3 3 3 1 Replication factor C C-terminal domain Aminotran_1_2 PF00155.21 EDP41928.1 - 2.4e-37 129.0 0.0 3.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II SET PF00856.28 EDP41929.1 - 2.2e-08 34.7 0.0 3.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 SET domain Peripla_BP_1 PF00532.21 EDP41929.1 - 0.069 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Actin PF00022.19 EDP41930.1 - 2.4e-50 171.3 0.0 1.1e-49 169.1 0.0 1.7 1 1 0 1 1 1 1 Actin PilM_2 PF11104.8 EDP41930.1 - 0.0067 15.5 0.0 1.6 7.7 0.0 2.1 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; MreB_Mbl PF06723.13 EDP41930.1 - 0.049 12.5 0.0 0.35 9.6 0.0 2.2 3 0 0 3 3 3 0 MreB/Mbl protein HSP70 PF00012.20 EDP41930.1 - 0.21 9.7 0.0 0.58 8.3 0.0 1.6 2 0 0 2 2 2 0 Hsp70 protein Pro_isomerase PF00160.21 EDP41931.1 - 2.1e-50 171.1 0.2 2.5e-50 170.8 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Mss4 PF04421.13 EDP41932.1 - 4.1e-08 33.3 0.1 3.5e-07 30.3 0.1 2.3 1 1 0 1 1 1 1 Mss4 protein Acetyltransf_7 PF13508.7 EDP41932.1 - 0.0048 17.3 0.0 0.0082 16.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP41932.1 - 0.019 15.2 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family TRAM_LAG1_CLN8 PF03798.16 EDP41933.1 - 2.7e-36 125.2 31.3 2.7e-36 125.2 31.3 1.9 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EDP41933.1 - 1.7e-18 66.0 0.2 1.7e-18 66.0 0.2 2.7 2 1 0 2 2 2 1 TRAM1-like protein Peptidase_Mx PF15887.5 EDP41933.1 - 0.025 14.0 1.3 0.041 13.3 1.3 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase CobS PF02654.15 EDP41933.1 - 1.1 9.4 5.6 0.73 10.0 3.4 1.9 2 1 0 2 2 2 0 Cobalamin-5-phosphate synthase DnaJ PF00226.31 EDP41934.1 - 2.3e-15 56.4 2.4 4.5e-15 55.5 2.4 1.5 1 0 0 1 1 1 1 DnaJ domain PIN_12 PF16289.5 EDP41934.1 - 0.043 14.3 0.2 0.34 11.4 0.0 2.1 2 0 0 2 2 2 0 PIN domain RecO_C PF02565.15 EDP41934.1 - 0.055 13.3 0.4 0.18 11.6 0.1 1.8 2 0 0 2 2 2 0 Recombination protein O C terminal NAGLU_C PF12972.7 EDP41934.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain DEAD PF00270.29 EDP41935.1 - 1.2e-39 135.9 0.0 2e-39 135.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP41935.1 - 9.5e-16 58.1 0.0 7.3e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDP41935.1 - 3.2e-08 33.8 0.0 7.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDP41935.1 - 0.036 14.4 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 EDP41935.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain Cyt-b5 PF00173.28 EDP41936.1 - 1.5e-21 76.3 0.1 1.5e-21 76.3 0.1 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EDP41936.1 - 7.6e-14 52.2 20.3 7.6e-14 52.2 20.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TMEM189_B_dmain PF10520.9 EDP41936.1 - 0.039 14.1 6.0 1.4 9.0 1.7 2.5 1 1 1 2 2 2 0 B domain of TMEM189, localisation domain Lactamase_B_4 PF13691.6 EDP41937.1 - 1.1e-16 60.2 0.0 1e-15 57.1 0.0 2.7 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EDP41937.1 - 1.1e-15 57.7 3.4 2.6e-11 43.4 2.4 3.5 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDP41937.1 - 0.027 14.5 0.1 0.083 12.9 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily RNase_P_Rpp14 PF01900.19 EDP41937.1 - 0.13 12.6 0.0 0.87 9.9 0.0 2.2 2 0 0 2 2 2 0 Rpp14/Pop5 family PH PF00169.29 EDP41938.1 - 1.3e-05 25.6 0.0 2.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 PH domain Ribosomal_60s PF00428.19 EDP41938.1 - 0.00011 22.7 7.7 0.0003 21.3 7.7 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein RNA_pol_3_Rpc31 PF11705.8 EDP41938.1 - 0.11 12.8 11.4 0.059 13.6 7.5 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 EDP41938.1 - 0.14 12.6 9.0 0.29 11.6 9.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4746 PF15928.5 EDP41938.1 - 0.19 11.2 6.3 0.36 10.2 6.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NOA36 PF06524.12 EDP41938.1 - 0.29 10.4 5.1 0.43 9.9 5.1 1.2 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 EDP41938.1 - 1.1 9.0 7.7 3.6 7.3 2.7 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 EDP41938.1 - 3.9 6.5 10.8 6.6 5.8 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Med4 PF10018.9 EDP41938.1 - 6.1 6.5 10.8 0.57 9.8 0.7 2.3 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DNA_pol_phi PF04931.13 EDP41938.1 - 8.5 4.3 10.1 17 3.3 10.1 1.4 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 EDP41939.1 - 2.5e-44 148.4 21.9 1.1e-07 32.4 0.1 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41939.1 - 2.3e-24 85.5 2.8 9.8e-07 29.0 0.0 6.1 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDP41939.1 - 9.4e-08 32.2 0.1 0.0068 16.3 0.0 3.4 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EDP41939.1 - 3.4e-05 23.0 0.3 0.049 12.6 0.1 3.5 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EDP41939.1 - 0.0061 14.6 0.0 1.1 7.2 0.0 2.7 2 1 1 3 3 3 2 IKI3 family Gaa1 PF04114.14 EDP41940.1 - 7.4e-77 259.5 0.0 5.7e-76 256.5 0.0 2.0 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component Methyltransf_23 PF13489.6 EDP41941.1 - 4.4e-21 75.4 0.0 6.4e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP41941.1 - 3.4e-17 62.9 0.0 8.4e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP41941.1 - 3.3e-13 50.2 0.2 2.4e-12 47.4 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP41941.1 - 5.2e-13 49.6 0.0 9.8e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP41941.1 - 1.2e-12 47.8 0.0 1.9e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDP41941.1 - 1.5e-06 27.7 0.0 3.1e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EDP41941.1 - 0.00017 20.7 0.0 0.00028 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 EDP41941.1 - 0.00025 20.4 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EDP41941.1 - 0.0012 18.3 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDP41941.1 - 0.052 13.1 0.1 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 EDP41941.1 - 0.15 11.7 0.4 0.25 10.9 0.4 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW TPMT PF05724.11 EDP41941.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CLU PF13236.6 EDP41942.1 - 5.6e-72 242.2 0.0 1.3e-71 241.0 0.0 1.7 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EDP41942.1 - 3e-49 167.4 0.0 7.4e-49 166.2 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_10 PF13374.6 EDP41942.1 - 1.1e-21 76.0 1.7 5.8e-08 32.4 0.2 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDP41942.1 - 6.7e-20 71.2 3.9 1.2e-11 44.7 0.4 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat CLU_N PF15044.6 EDP41942.1 - 1.3e-09 38.3 0.0 2.3e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term DUF727 PF05303.12 EDP41942.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF727) HMG-CoA_red PF00368.18 EDP41943.1 - 1.6e-141 471.6 2.9 2.2e-141 471.1 2.9 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 EDP41943.1 - 5.7e-14 52.2 3.7 6.6e-09 35.8 0.3 2.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation IgaA PF07095.11 EDP41943.1 - 0.0023 16.0 0.3 0.0039 15.2 0.3 1.2 1 0 0 1 1 1 1 Intracellular growth attenuator protein IgaA Patched PF02460.18 EDP41943.1 - 0.02 13.0 0.0 0.037 12.1 0.0 1.3 1 1 0 1 1 1 0 Patched family AMP-binding PF00501.28 EDP41945.1 - 7.5e-93 311.4 0.0 1e-92 311.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDP41945.1 - 0.00068 20.6 0.1 0.0028 18.6 0.1 2.2 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain DJ-1_PfpI PF01965.24 EDP41946.1 - 6.5e-28 97.6 0.0 7.6e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 EDP41946.1 - 0.00019 21.1 0.0 0.0003 20.5 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain found in long catalases GATase_3 PF07685.14 EDP41946.1 - 0.034 13.8 0.4 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain Sec63 PF02889.16 EDP41947.1 - 1.6e-143 476.4 0.0 2e-77 259.9 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EDP41947.1 - 1.5e-44 151.8 0.0 5.4e-26 91.4 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EDP41947.1 - 3.3e-36 123.8 0.2 8.7e-36 122.5 0.2 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EDP41947.1 - 5e-23 82.0 0.0 1.2e-15 57.9 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP41947.1 - 8.4e-13 48.6 0.0 5.1e-08 33.2 0.0 3.7 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDP41947.1 - 1.8e-05 25.1 0.4 0.24 11.7 0.1 3.8 4 1 0 4 4 4 2 AAA domain AAA_7 PF12775.7 EDP41947.1 - 0.15 11.6 0.0 13 5.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region PHD PF00628.29 EDP41948.1 - 9.3e-07 28.7 14.7 1.9e-06 27.7 14.7 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 EDP41948.1 - 2.2e-06 28.2 0.0 1.2e-05 25.8 0.0 2.3 1 1 0 1 1 1 1 SET domain PHD_2 PF13831.6 EDP41948.1 - 0.005 16.4 7.3 0.01 15.4 7.3 1.5 1 0 0 1 1 1 1 PHD-finger HEAT_EZ PF13513.6 EDP41949.1 - 6.7e-05 23.3 7.6 0.057 14.0 0.1 6.1 6 0 0 6 6 6 2 HEAT-like repeat GDI PF00996.18 EDP41949.1 - 0.028 13.0 0.0 0.043 12.3 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Anticodon_1 PF08264.13 EDP41950.1 - 0.0051 16.8 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA PG_binding_1 PF01471.18 EDP41950.1 - 0.026 14.7 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Putative peptidoglycan binding domain NPA PF16469.5 EDP41950.1 - 0.16 12.6 0.0 0.26 11.9 0.0 1.3 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 PCI PF01399.27 EDP41951.1 - 0.058 13.9 0.1 0.13 12.8 0.1 1.6 1 0 0 1 1 1 0 PCI domain UvrD-helicase PF00580.21 EDP41952.1 - 5.8e-13 49.1 0.0 6.2e-10 39.1 0.0 2.4 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EDP41952.1 - 8.3e-12 45.1 0.0 1.5e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EDP41952.1 - 9.6e-12 45.5 0.0 2.1e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EDP41952.1 - 2.1e-10 40.3 0.2 1.7e-09 37.4 0.2 2.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EDP41952.1 - 4.1e-08 33.2 0.0 0.00054 19.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EDP41952.1 - 4.9e-08 33.0 0.1 0.045 13.5 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EDP41952.1 - 5.5e-05 22.7 0.0 0.16 11.4 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein AAA_22 PF13401.6 EDP41952.1 - 0.0013 19.0 0.0 0.6 10.4 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EDP41952.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain BolA PF01722.18 EDP41953.1 - 5.1e-17 61.9 0.1 1.2e-16 60.7 0.1 1.6 1 0 0 1 1 1 1 BolA-like protein CN_hydrolase PF00795.22 EDP41954.1 - 3.7e-06 26.5 0.0 4e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase RNA_pol_Rpb5_C PF01191.19 EDP41954.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain ResIII PF04851.15 EDP41956.1 - 3.1e-22 79.4 0.0 1e-21 77.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP41956.1 - 8.9e-20 71.1 0.2 1.8e-19 70.1 0.2 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP41956.1 - 4.9e-18 65.5 0.0 3e-16 59.7 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EDP41956.1 - 1.6e-05 24.7 0.0 3.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase NPR3 PF03666.13 EDP41957.1 - 3.9e-62 210.6 16.1 6.1e-52 177.0 2.2 3.1 2 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 EDP41957.1 - 0.0002 20.3 0.0 0.0077 15.0 0.0 2.7 3 0 0 3 3 3 1 Nitrogen permease regulator 2 Ocular_alb PF02101.15 EDP41957.1 - 0.18 10.7 0.1 0.3 10.0 0.1 1.2 1 0 0 1 1 1 0 Ocular albinism type 1 protein FAM92 PF06730.11 EDP41957.1 - 0.49 9.8 4.0 7.2 6.0 0.1 2.7 3 0 0 3 3 3 0 FAM92 protein Drf_GBD PF06371.13 EDP41958.1 - 1e-10 41.5 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Kinesin PF00225.23 EDP41959.1 - 6.5e-104 347.4 0.1 1e-103 346.8 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDP41959.1 - 4.1e-25 88.5 0.0 8.9e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 EDP41959.1 - 0.14 12.0 0.3 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein PapD-like PF14874.6 EDP41960.1 - 0.032 14.4 0.2 1.2 9.3 0.1 2.6 2 0 0 2 2 2 0 Flagellar-associated PapD-like PapD-like PF14874.6 EDP41961.1 - 6.8e-08 32.6 0.0 0.0026 17.9 0.1 3.5 3 0 0 3 3 3 2 Flagellar-associated PapD-like ASH PF15780.5 EDP41961.1 - 6.4e-06 26.3 0.0 0.016 15.4 0.0 4.0 3 1 0 3 3 3 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 EDP41961.1 - 2.8e-05 24.3 1.5 0.067 13.4 0.0 4.6 4 1 1 5 5 5 2 Transmembrane protein 131-like DUF1573 PF07610.11 EDP41961.1 - 0.17 11.9 0.0 4.2 7.5 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1573) Vps39_1 PF10366.9 EDP41962.1 - 1.1e-24 86.8 0.1 5.6e-24 84.5 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EDP41962.1 - 6.9e-22 78.0 0.8 3.6e-21 75.7 0.3 2.5 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EDP41962.1 - 9.2e-11 41.8 0.2 1.3e-05 25.1 0.0 3.2 4 0 0 4 4 4 2 Region in Clathrin and VPS CNH PF00780.22 EDP41962.1 - 4.4e-06 26.5 0.0 4e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 CNH domain TPR_10 PF13374.6 EDP41962.1 - 0.074 12.9 3.1 9 6.3 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 EDP41962.1 - 0.18 12.1 0.4 90 3.7 0.0 4.0 4 0 0 4 4 4 0 PPR repeat TPR_7 PF13176.6 EDP41962.1 - 2.2 8.5 7.1 12 6.2 0.3 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDP41962.1 - 2.3 8.6 6.3 9.2 6.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EDP41963.1 - 1.5e-46 159.3 0.0 1.7e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDP41963.1 - 0.013 14.7 0.0 0.17 11.1 0.0 2.2 3 0 0 3 3 3 0 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EDP41963.1 - 0.015 13.9 0.0 0.024 13.2 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Peptidase_M1 PF01433.20 EDP41966.1 - 1.7e-65 220.6 1.6 2.8e-65 219.9 1.6 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EDP41966.1 - 4.5e-57 194.0 3.7 8.9e-57 193.0 3.7 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EDP41966.1 - 8.4e-35 120.6 0.1 9.3e-33 114.0 0.1 2.4 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain DUF5421 PF17458.2 EDP41966.1 - 0.2 11.0 0.1 0.41 10.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5421) ERAP1_C PF11838.8 EDP41967.1 - 2.6e-72 244.0 1.8 4.8e-72 243.2 1.8 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EDP41967.1 - 3.5e-64 216.4 0.8 5.4e-64 215.7 0.8 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDP41967.1 - 3.3e-32 112.2 0.0 1.2e-30 107.1 0.0 2.5 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 EDP41968.1 - 2.6e-74 250.6 1.2 3.2e-74 250.3 0.5 1.5 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EDP41968.1 - 3.2e-68 229.5 0.1 5.2e-68 228.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EDP41968.1 - 1.5e-38 132.8 0.0 6.4e-37 127.5 0.0 2.4 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain SEP PF08059.13 EDP41969.1 - 1.6e-24 86.3 0.0 4.6e-24 84.8 0.0 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EDP41969.1 - 0.0042 17.2 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 UBX domain Mito_carr PF00153.27 EDP41970.1 - 1.6e-38 130.5 4.0 1.6e-22 79.2 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Fuseless PF15993.5 EDP41970.1 - 0.0088 15.3 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 1 Fuseless Ras PF00071.22 EDP41971.1 - 6.5e-41 139.6 0.2 7.6e-41 139.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP41971.1 - 6.5e-21 74.8 0.2 2.3e-20 73.0 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP41971.1 - 1.3e-09 37.8 0.1 6.2e-09 35.5 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDP41971.1 - 0.00021 20.9 0.1 0.00027 20.5 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDP41971.1 - 0.00074 18.9 0.0 0.00097 18.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SWIB PF02201.18 EDP41972.1 - 2.7e-20 72.0 0.0 5.2e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain TFIIA PF03153.13 EDP41972.1 - 0.16 12.0 7.5 0.32 10.9 7.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_S9 PF00380.19 EDP41973.1 - 3.3e-31 108.3 0.1 3.7e-31 108.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L4 PF00573.22 EDP41974.1 - 6.7e-59 198.8 0.0 9.2e-59 198.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family NUFIP1 PF10453.9 EDP41975.1 - 1.1e-08 34.8 0.1 2.6e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) EFTUD2 PF16004.5 EDP41975.1 - 0.31 11.6 0.0 0.31 11.6 0.0 3.0 2 1 1 3 3 3 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus RAP1 PF07218.11 EDP41975.1 - 2.7 6.1 9.5 3.7 5.7 9.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ABC_tran PF00005.27 EDP41976.1 - 3e-45 154.1 0.0 1e-26 94.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDP41976.1 - 6.6e-44 150.6 26.4 1.2e-24 87.5 10.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EDP41976.1 - 6.6e-13 48.6 0.5 0.021 14.3 0.0 4.6 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDP41976.1 - 4.6e-08 33.8 0.1 0.015 15.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EDP41976.1 - 5.5e-08 32.4 0.0 0.0005 19.8 0.0 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDP41976.1 - 5.8e-07 29.6 1.7 0.062 13.1 0.2 4.2 2 2 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDP41976.1 - 7.2e-07 29.6 0.5 0.081 13.2 0.0 3.8 4 1 0 4 4 4 2 AAA domain AAA_16 PF13191.6 EDP41976.1 - 5.2e-06 26.9 0.1 0.016 15.6 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 EDP41976.1 - 3.9e-05 22.9 0.0 0.04 13.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EDP41976.1 - 0.00021 21.2 0.0 0.46 10.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDP41976.1 - 0.00041 20.4 0.0 0.065 13.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EDP41976.1 - 0.0012 18.5 0.2 0.31 10.6 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EDP41976.1 - 0.0013 18.3 0.0 0.46 10.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 EDP41976.1 - 0.0013 17.7 0.0 0.5 9.2 0.0 2.2 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 EDP41976.1 - 0.0014 18.1 0.0 1.7 7.9 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family Zeta_toxin PF06414.12 EDP41976.1 - 0.0031 16.8 0.0 1.4 8.2 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 EDP41976.1 - 0.013 15.4 0.2 21 5.0 0.0 3.4 3 0 0 3 3 3 0 NACHT domain Roc PF08477.13 EDP41976.1 - 0.019 15.2 0.1 2.3 8.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EDP41976.1 - 0.024 14.6 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 EDP41976.1 - 0.036 14.5 0.0 7.8 6.9 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EDP41976.1 - 0.046 14.1 0.0 13 6.2 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.6 EDP41976.1 - 0.048 13.4 0.0 16 5.1 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 EDP41976.1 - 0.052 13.6 0.4 4.9 7.2 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 EDP41976.1 - 0.061 13.4 0.1 2.5 8.1 0.1 2.5 2 0 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 EDP41976.1 - 0.073 12.8 0.0 12 5.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EDP41976.1 - 0.075 13.1 0.6 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain DEAD PF00270.29 EDP41976.1 - 0.15 11.8 0.1 29 4.4 0.1 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase Sigma54_activat PF00158.26 EDP41976.1 - 0.15 11.7 0.0 22 4.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EDP41976.1 - 0.2 11.5 0.6 17 5.2 0.0 3.6 4 1 1 5 5 4 0 ATPase domain predominantly from Archaea GCV_T PF01571.21 EDP41977.1 - 5.5e-74 248.8 0.1 7e-74 248.4 0.1 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EDP41977.1 - 3.2e-20 71.8 0.0 7.6e-20 70.6 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 EDP41977.1 - 0.095 12.8 0.1 0.24 11.5 0.0 1.7 2 0 0 2 2 2 0 Sarcosine oxidase, gamma subunit family LRR_8 PF13855.6 EDP41978.1 - 2.6e-14 52.7 21.2 1e-09 38.0 7.7 4.3 4 1 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EDP41978.1 - 1.2e-11 44.7 16.2 2.5e-05 24.5 3.2 4.7 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) Torus PF16131.5 EDP41978.1 - 3.4e-07 30.9 4.9 0.0076 16.9 0.4 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 EDP41978.1 - 9.4e-07 28.5 10.1 0.00078 19.2 1.7 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EDP41978.1 - 5.5e-06 26.2 7.1 0.00041 20.2 0.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP41978.1 - 0.00015 21.7 15.1 0.00091 19.2 3.5 2.4 2 0 0 2 2 2 2 Zinc finger domain LRR_6 PF13516.6 EDP41978.1 - 0.00019 21.2 19.9 14 6.1 0.0 7.3 8 0 0 8 8 8 2 Leucine Rich repeat zf-CCCH_3 PF15663.5 EDP41978.1 - 0.0012 19.0 0.6 0.0024 18.1 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger containing family LRR_1 PF00560.33 EDP41978.1 - 0.049 14.2 15.7 55 4.9 0.2 6.8 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_9 PF14580.6 EDP41978.1 - 0.09 12.3 0.5 12 5.4 0.0 2.2 1 1 1 2 2 2 0 Leucine-rich repeat Sugar_tr PF00083.24 EDP41979.1 - 4.5e-19 68.6 19.1 1.4e-11 44.0 6.0 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter WD40 PF00400.32 EDP41980.1 - 3.5e-26 90.9 15.1 0.00079 20.2 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP41980.1 - 1.1e-07 32.1 0.6 0.7 10.2 0.3 4.3 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain CHCH PF06747.13 EDP41981.1 - 3.3e-08 33.5 4.6 6.3e-08 32.5 4.6 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EDP41981.1 - 0.0026 18.1 1.7 0.005 17.2 1.7 1.5 1 0 0 1 1 1 1 GCK domain Tom5 PF10642.9 EDP41981.1 - 0.3 11.1 0.2 0.3 11.1 0.2 2.5 3 0 0 3 3 3 0 Mitochondrial import receptor subunit or translocase adh_short PF00106.25 EDP41982.1 - 5.4e-08 32.5 0.0 9.3e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Ytp1 PF10355.9 EDP41983.1 - 4.1e-54 183.7 13.6 4.6e-52 176.9 13.6 2.2 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) SAM_1 PF00536.30 EDP41984.1 - 4.7e-17 62.2 0.0 8.7e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EDP41984.1 - 3.4e-15 55.9 0.0 6.1e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 EDP41984.1 - 4.1e-08 32.7 0.0 3.7e-06 26.4 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EDP41984.1 - 3.5e-05 23.6 0.2 0.0038 17.1 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain RA PF00788.23 EDP41984.1 - 0.00017 22.1 0.0 0.0004 21.0 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_PNT PF02198.16 EDP41984.1 - 0.0096 15.9 0.0 0.043 13.8 0.0 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SIM_C PF06621.12 EDP41984.1 - 0.17 11.9 0.2 0.36 10.8 0.2 1.4 1 0 0 1 1 1 0 Single-minded protein C-terminus SAM_3 PF18016.1 EDP41984.1 - 0.19 11.5 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Sec7 PF01369.20 EDP41985.1 - 5e-19 68.7 0.0 8.7e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Cullin PF00888.22 EDP41986.1 - 2.6e-08 33.0 0.0 4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Cullin family RmlD_sub_bind PF04321.17 EDP41987.1 - 1.7e-55 188.2 0.0 2.8e-55 187.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Vps5 PF09325.10 EDP41987.1 - 1.3e-38 132.9 5.3 2.4e-38 132.0 5.3 1.3 1 0 0 1 1 1 1 Vps5 C terminal like Epimerase PF01370.21 EDP41987.1 - 9e-25 87.5 0.0 1.6e-24 86.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PX PF00787.24 EDP41987.1 - 4.9e-23 81.3 0.0 9.8e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 PX domain GDP_Man_Dehyd PF16363.5 EDP41987.1 - 8.6e-13 48.4 2.4 2.6e-12 46.8 0.1 2.7 2 2 1 3 3 3 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDP41987.1 - 6.4e-08 32.1 0.3 8.2e-06 25.2 0.3 2.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EDP41987.1 - 0.0006 19.1 0.0 0.045 12.9 0.0 2.7 1 1 1 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 EDP41987.1 - 0.0026 16.8 0.0 0.0058 15.7 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EDP41987.1 - 0.0079 15.8 0.1 0.023 14.3 0.1 1.7 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.20 EDP41987.1 - 0.0083 16.2 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 EDP41987.1 - 0.019 14.5 0.0 0.043 13.3 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase bHLH-MYC_N PF14215.6 EDP41987.1 - 0.14 12.5 0.3 0.34 11.2 0.3 1.6 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal NAD_binding_10 PF13460.6 EDP41987.1 - 0.31 10.9 2.3 0.29 11.0 0.1 2.2 3 0 0 3 3 3 0 NAD(P)H-binding Vezatin PF12632.7 EDP41989.1 - 5.2e-15 55.6 0.2 1.3e-11 44.4 0.0 2.4 2 0 0 2 2 2 2 Mysoin-binding motif of peroxisomes 60KD_IMP PF02096.20 EDP41990.1 - 1.2e-24 87.0 3.3 1.7e-24 86.6 3.3 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Troponin-I_N PF11636.8 EDP41990.1 - 0.021 14.8 3.5 0.059 13.3 3.5 1.8 1 0 0 1 1 1 0 Troponin I residues 1-32 TBP PF00352.21 EDP41991.1 - 4.8e-61 202.7 0.2 3.6e-32 110.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EDP41991.1 - 1.3e-05 25.2 0.0 0.19 11.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EDP41991.1 - 0.15 11.9 0.1 0.76 9.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) HSF_DNA-bind PF00447.17 EDP41992.1 - 9.8e-32 109.4 0.4 1.4e-31 108.9 0.4 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding RNA_pol_Rpc82 PF05645.13 EDP41994.1 - 3.5e-14 53.2 0.2 5.9e-14 52.4 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EDP41994.1 - 9e-06 25.7 2.4 0.0078 16.3 0.6 3.7 3 1 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EDP41994.1 - 0.002 17.9 0.1 0.0061 16.4 0.1 1.9 1 0 0 1 1 1 1 TFIIE alpha subunit SNARE_assoc PF09335.11 EDP41995.1 - 1.8e-11 44.6 2.8 3.1e-11 43.8 2.8 1.4 1 0 0 1 1 1 1 SNARE associated Golgi protein DUF2554 PF10829.8 EDP41995.1 - 0.069 13.6 0.0 0.22 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2554) Sld5 PF05916.11 EDP41996.1 - 3.2e-07 30.8 0.2 6.9e-07 29.7 0.0 1.5 2 0 0 2 2 2 1 GINS complex protein RRM_1 PF00076.22 EDP41997.1 - 2.4e-37 126.6 0.0 4.9e-15 55.1 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP41997.1 - 0.0058 16.6 0.0 0.61 10.1 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EDP41997.1 - 0.041 13.5 0.0 1.4 8.6 0.0 2.6 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP41997.1 - 0.041 14.0 0.0 10 6.3 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif RRM_occluded PF16842.5 EDP41997.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EDP41997.1 - 0.19 12.0 0.0 21 5.3 0.0 3.1 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter UPF0052 PF01933.18 EDP41998.1 - 1.6e-10 40.7 0.0 1.7e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 tRNA_U5-meth_tr PF05958.11 EDP41999.1 - 3.3e-11 42.8 0.0 5.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EDP41999.1 - 2.6e-07 30.6 0.0 4.5e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.20 EDP41999.1 - 3e-06 27.1 0.0 6.1e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 TRAM domain Methyltransf_25 PF13649.6 EDP41999.1 - 3.5e-06 27.6 0.0 7.5e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EDP41999.1 - 6.9e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EDP41999.1 - 0.00016 21.2 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDP41999.1 - 0.00021 20.9 0.0 0.0004 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EDP41999.1 - 0.00023 21.7 0.0 0.00055 20.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 EDP41999.1 - 0.0023 17.6 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 EDP41999.1 - 0.019 15.7 0.0 0.042 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EDP41999.1 - 0.025 14.0 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.6 EDP41999.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EDP41999.1 - 0.082 12.6 0.0 0.28 10.9 0.0 1.8 1 1 1 2 2 2 0 Met-10+ like-protein Ubie_methyltran PF01209.18 EDP41999.1 - 0.18 11.1 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family EamA PF00892.20 EDP42000.1 - 1e-11 45.2 37.7 3e-08 33.9 5.8 4.0 4 0 0 4 4 4 4 EamA-like transporter family RhoGAP PF00620.27 EDP42002.1 - 1.9e-38 131.7 0.1 7e-38 129.8 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain Jnk-SapK_ap_N PF09744.9 EDP42002.1 - 0.054 13.7 2.1 0.11 12.7 2.1 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 MCU PF04678.13 EDP42002.1 - 0.25 11.4 2.4 0.41 10.7 2.4 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter KH_1 PF00013.29 EDP42003.1 - 4.6e-31 106.4 0.0 6.7e-08 32.3 0.0 5.9 6 0 0 6 6 6 4 KH domain Macoilin PF09726.9 EDP42003.1 - 0.028 13.0 1.8 0.043 12.4 1.8 1.2 1 0 0 1 1 1 0 Macoilin family Secretin_N PF03958.17 EDP42003.1 - 0.86 10.0 0.0 0.86 10.0 0.0 3.6 4 0 0 4 4 4 0 Bacterial type II/III secretion system short domain Menin PF05053.13 EDP42003.1 - 1.2 7.4 3.6 1.7 6.9 3.6 1.1 1 0 0 1 1 1 0 Menin SR-25 PF10500.9 EDP42003.1 - 8.9 5.9 11.0 27 4.3 11.0 1.8 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpb5_N PF03871.14 EDP42004.1 - 9.4e-29 99.8 1.1 1.3e-28 99.3 0.6 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.19 EDP42004.1 - 2.7e-06 27.1 1.6 2.7e-06 27.1 1.6 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain Mrr_cat PF04471.12 EDP42004.1 - 2e-05 24.6 0.1 3e-05 24.0 0.1 1.3 1 1 0 1 1 1 1 Restriction endonuclease Mrr_cat_2 PF13156.6 EDP42004.1 - 0.013 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease Ribosomal_L27A PF00828.19 EDP42004.1 - 0.09 13.5 0.2 0.16 12.7 0.2 1.4 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A NAD_binding_1 PF00175.21 EDP42005.1 - 6.7e-28 97.5 0.0 1e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDP42005.1 - 2e-18 66.6 0.0 4e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDP42005.1 - 3.3e-06 27.3 0.0 0.0015 18.7 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EDP42005.1 - 0.011 16.0 0.0 0.034 14.4 0.0 1.9 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain ABC_ATPase PF09818.9 EDP42006.1 - 9.4e-153 509.2 0.0 1.1e-152 508.9 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_25 PF13481.6 EDP42006.1 - 0.033 13.8 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Chitin_synth_2 PF03142.15 EDP42007.1 - 4.9e-226 751.4 0.1 6.8e-226 751.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDP42007.1 - 1.2e-15 57.9 7.0 1.2e-14 54.7 4.8 2.6 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDP42007.1 - 4.4e-14 52.9 0.2 9.8e-13 48.5 0.1 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDP42007.1 - 0.011 15.3 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EDP42007.1 - 0.11 12.3 0.0 0.91 9.3 0.0 2.3 3 0 0 3 3 3 0 Glycosyl transferase family 2 DSPc PF00782.20 EDP42008.1 - 2.2e-05 24.3 0.1 0.00012 21.9 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EDP42008.1 - 0.00033 20.3 0.1 0.0006 19.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 EDP42008.1 - 0.00072 19.2 0.3 0.0025 17.4 0.1 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EDP42008.1 - 0.0019 18.3 0.1 0.0069 16.5 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate SLC35F PF06027.12 EDP42009.1 - 1.9e-07 30.9 3.3 1.9e-07 30.9 3.3 2.0 2 0 0 2 2 2 1 Solute carrier family 35 EamA PF00892.20 EDP42009.1 - 0.00018 21.7 6.9 0.00018 21.7 6.9 3.1 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 EDP42009.1 - 0.0017 17.6 0.4 0.0045 16.2 0.4 1.7 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 EDP42009.1 - 0.033 13.4 5.2 0.016 14.4 1.2 2.1 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport BAH PF01426.18 EDP42010.1 - 1.8e-13 50.4 0.0 2.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 BAH domain Bromodomain PF00439.25 EDP42010.1 - 1.9e-12 47.1 0.0 4.8e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Pkinase PF00069.25 EDP42011.1 - 8e-63 212.3 0.0 9.2e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42011.1 - 3.6e-19 69.1 0.0 5e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP42011.1 - 3.4e-07 30.4 0.0 2.3e-06 27.7 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP42011.1 - 0.0071 15.7 0.1 0.014 14.8 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDP42011.1 - 0.017 13.9 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Aconitase_B_N PF11791.8 EDP42011.1 - 0.031 14.4 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 Aconitate B N-terminal domain Choline_kinase PF01633.20 EDP42011.1 - 0.033 13.8 0.1 0.033 13.8 0.1 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase tRNA-synt_1b PF00579.25 EDP42012.1 - 1.1e-20 74.2 0.0 6.5e-20 71.6 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Vmethyltransf PF01660.17 EDP42012.1 - 0.0074 15.2 0.1 0.0098 14.8 0.1 1.2 1 0 0 1 1 1 1 Viral methyltransferase LSM PF01423.22 EDP42013.1 - 1.5e-14 53.4 0.0 2e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDP42013.1 - 0.00091 19.3 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 EDP42013.1 - 0.055 13.6 0.1 0.075 13.2 0.1 1.5 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Fimbrial_CS1 PF04449.12 EDP42013.1 - 0.098 12.8 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 CS1 type fimbrial major subunit Avl9 PF09794.9 EDP42014.1 - 1.4e-52 178.7 0.0 2.5e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EDP42014.1 - 0.0014 18.5 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Fibrillarin PF01269.17 EDP42016.1 - 1.6e-108 361.1 0.0 2e-108 360.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EDP42016.1 - 1.1e-05 25.3 0.0 1.6e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EDP42016.1 - 0.0044 16.8 0.1 0.0088 15.8 0.1 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 EDP42016.1 - 0.046 13.4 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDP42016.1 - 0.064 13.4 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Tubulin PF00091.25 EDP42017.1 - 2.7e-67 226.8 0.0 3.8e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDP42017.1 - 3e-44 150.2 0.1 5.6e-44 149.3 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EDP42017.1 - 4.9e-05 23.6 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EDP42017.1 - 0.046 12.9 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Ion_trans PF00520.31 EDP42018.1 - 5.8e-117 389.2 68.8 1.6e-41 142.2 2.1 6.1 5 1 1 6 6 6 6 Ion transport protein GPHH PF16905.5 EDP42018.1 - 0.13 12.0 0.0 0.39 10.5 0.0 1.8 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated BCS1_N PF08740.11 EDP42019.1 - 3.2e-54 183.7 0.1 4.6e-54 183.2 0.1 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EDP42019.1 - 7e-17 62.1 0.0 1.3e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDP42019.1 - 0.00061 20.2 0.1 0.0034 17.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EDP42019.1 - 0.0033 18.0 0.0 0.011 16.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDP42019.1 - 0.0069 16.6 0.0 0.022 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDP42019.1 - 0.011 15.4 0.1 0.25 10.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDP42019.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 EDP42019.1 - 0.072 13.1 0.0 0.21 11.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EDP42019.1 - 0.085 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase PF06745.13 EDP42019.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 EDP42019.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDP42019.1 - 0.18 12.2 0.0 0.38 11.2 0.0 1.6 1 1 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 EDP42019.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MgtE PF01769.16 EDP42020.1 - 1.7e-36 125.4 24.4 2.9e-19 69.7 0.0 3.6 2 2 1 3 3 3 2 Divalent cation transporter PRA1 PF03208.19 EDP42020.1 - 1.8 8.2 18.2 2.6 7.7 5.7 3.0 2 0 0 2 2 2 0 PRA1 family protein PCI PF01399.27 EDP42021.1 - 6.5e-11 42.7 0.8 2.5e-10 40.8 0.1 2.5 2 0 0 2 2 2 1 PCI domain Peptidase_M15_2 PF05951.13 EDP42021.1 - 0.29 10.8 4.0 0.54 9.9 0.0 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF882) DUF382 PF04037.13 EDP42022.1 - 5.6e-57 191.4 0.1 9.3e-57 190.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EDP42022.1 - 1.2e-18 66.7 4.2 4.3e-18 64.9 4.2 2.0 1 0 0 1 1 1 1 PSP CDC45 PF02724.14 EDP42022.1 - 0.84 7.9 7.8 1.3 7.2 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EDP42022.1 - 3.2 7.1 9.4 5.3 6.4 9.4 1.3 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EDP42022.1 - 5 5.1 14.1 7.3 4.5 14.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EDP42022.1 - 8.7 4.4 10.0 14 3.8 10.0 1.2 1 0 0 1 1 1 0 Nop14-like family Proteasome PF00227.26 EDP42024.1 - 3.6e-50 170.1 0.1 4.6e-50 169.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EDP42024.1 - 5e-11 41.8 0.1 5e-11 41.8 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Rio2_N PF09202.11 EDP42024.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Rio2, N-terminal Pyr_redox_2 PF07992.14 EDP42025.1 - 2.4e-34 118.9 0.0 3e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EDP42025.1 - 2e-13 50.1 0.0 4.6e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EDP42025.1 - 3.3e-07 30.8 0.1 4.7e-06 27.1 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 EDP42025.1 - 2.9e-05 23.9 0.0 6.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Reductase_C PF14759.6 EDP42025.1 - 8.6e-05 23.0 0.0 0.00018 22.0 0.0 1.6 1 0 0 1 1 1 1 Reductase C-terminal Pyr_redox_3 PF13738.6 EDP42025.1 - 0.0047 16.2 0.1 0.041 13.1 0.1 2.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDP42025.1 - 0.025 13.7 1.5 0.54 9.3 0.0 2.2 1 1 1 2 2 2 0 FAD binding domain Thi4 PF01946.17 EDP42025.1 - 0.03 13.6 0.1 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 Thi4 family AIF_C PF14721.6 EDP42025.1 - 0.11 12.9 0.1 2 8.8 0.0 2.4 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EF-hand_4 PF12763.7 EDP42026.1 - 1.1e-36 125.0 0.0 4.9e-15 55.4 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EDP42026.1 - 2.1e-07 31.3 0.0 0.0024 18.3 0.1 4.3 5 0 0 5 5 5 1 EF-hand domain pair EF-hand_1 PF00036.32 EDP42026.1 - 2e-06 26.9 0.0 0.27 10.9 0.0 4.7 5 0 0 5 5 5 1 EF hand EF-hand_6 PF13405.6 EDP42026.1 - 3.7e-05 23.3 1.3 2.9 8.0 0.0 5.6 7 0 0 7 7 6 1 EF-hand domain Macoilin PF09726.9 EDP42026.1 - 4.5e-05 22.2 10.1 6.1e-05 21.8 10.1 1.1 1 0 0 1 1 1 1 Macoilin family FPP PF05911.11 EDP42026.1 - 0.0038 15.5 16.3 0.0052 15.1 16.3 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil EF-hand_8 PF13833.6 EDP42026.1 - 0.0048 16.7 0.0 3 7.7 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain pair AAA_13 PF13166.6 EDP42026.1 - 0.043 12.5 10.9 0.063 11.9 10.9 1.1 1 0 0 1 1 1 0 AAA domain PI3K_P85_iSH2 PF16454.5 EDP42026.1 - 0.074 12.6 17.5 0.14 11.7 17.5 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4201 PF13870.6 EDP42026.1 - 0.22 11.2 20.2 0.2 11.4 19.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) End3 PF12761.7 EDP42026.1 - 0.33 11.1 0.0 0.33 11.1 0.0 3.2 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 EzrA PF06160.12 EDP42026.1 - 0.54 8.4 16.4 0.75 7.9 16.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA V_ATPase_I PF01496.19 EDP42026.1 - 0.68 7.8 11.9 0.98 7.3 11.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 EDP42026.1 - 0.81 9.8 30.0 0.023 14.8 8.2 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding zf-C4H2 PF10146.9 EDP42026.1 - 1.3 9.3 14.1 0.03 14.6 4.5 2.5 2 0 0 2 2 2 0 Zinc finger-containing protein ATG16 PF08614.11 EDP42026.1 - 1.6 8.9 37.1 3.1 8.0 36.2 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF812 PF05667.11 EDP42026.1 - 2.2 7.1 21.3 5.3 5.8 21.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) CENP-Q PF13094.6 EDP42026.1 - 3.8 7.7 29.8 2.6 8.2 11.6 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fez1 PF06818.15 EDP42026.1 - 5.4 7.4 22.4 8.4 6.8 22.4 1.3 1 0 0 1 1 1 0 Fez1 Tup_N PF08581.10 EDP42026.1 - 5.5 7.4 14.5 8.6 6.8 7.5 2.9 1 1 2 3 3 3 0 Tup N-terminal DUF1515 PF07439.11 EDP42026.1 - 7.6 6.6 6.4 8.1 6.5 5.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) CENP-H PF05837.12 EDP42026.1 - 8.1 6.9 27.4 3.7 8.0 11.1 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) UBA PF00627.31 EDP42027.1 - 9e-07 28.7 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain UBA_3 PF09288.10 EDP42027.1 - 0.022 14.6 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain SAGA-Tad1 PF12767.7 EDP42028.1 - 1.7e-43 149.1 0.1 3.4e-43 148.1 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Pkinase PF00069.25 EDP42029.1 - 7.9e-55 186.0 0.0 9.8e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42029.1 - 2.5e-38 131.9 0.0 3.8e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP42029.1 - 2.4e-06 26.6 0.0 4.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP42029.1 - 5.1e-06 26.0 0.0 9.3e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP42029.1 - 0.018 14.9 2.5 0.12 12.3 0.0 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDP42029.1 - 0.045 13.1 0.0 0.09 12.1 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SPRY PF00622.28 EDP42030.1 - 7.3e-21 74.5 1.3 1.6e-20 73.4 0.3 1.9 2 0 0 2 2 2 1 SPRY domain bZIP_1 PF00170.21 EDP42031.1 - 2.7e-06 27.4 8.8 8e-06 25.9 8.3 2.0 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EDP42031.1 - 0.37 10.9 10.4 0.22 11.7 5.7 2.2 1 1 1 2 2 2 0 Basic region leucine zipper KTI12 PF08433.10 EDP42032.1 - 6.3e-46 157.0 0.0 7.3e-46 156.8 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EDP42032.1 - 3.1e-08 33.9 0.1 4.1e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EDP42034.1 - 2.7e-46 157.5 0.0 6.6e-46 156.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42034.1 - 4.3e-26 91.4 0.0 1.4e-25 89.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42034.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PAP_assoc PF03828.19 EDP42035.1 - 2.3e-16 59.7 0.2 1.4e-15 57.3 0.0 2.5 3 0 0 3 3 3 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EDP42035.1 - 3.9e-10 39.9 0.0 7.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDP42035.1 - 0.099 12.7 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase AAA PF00004.29 EDP42036.1 - 1.5e-32 112.8 0.0 2.1e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDP42036.1 - 2.4e-07 31.1 0.1 9.7e-07 29.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDP42036.1 - 2.1e-06 28.2 0.1 2.1e-05 25.0 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EDP42036.1 - 7.6e-06 26.0 0.0 1.4e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDP42036.1 - 9.1e-06 25.9 0.0 2.6e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 EDP42036.1 - 1.3e-05 25.0 0.0 5.1e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EDP42036.1 - 1.7e-05 25.3 0.0 3.6e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EDP42036.1 - 3.3e-05 23.9 0.0 6.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP42036.1 - 8.5e-05 22.7 0.0 0.00015 21.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDP42036.1 - 0.00019 21.2 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EDP42036.1 - 0.00026 20.8 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 EDP42036.1 - 0.00034 20.6 0.1 0.36 10.7 0.2 2.2 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea RuvB_N PF05496.12 EDP42036.1 - 0.00037 20.3 0.2 0.0041 16.9 0.0 2.1 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EDP42036.1 - 0.00047 20.1 0.1 0.0014 18.6 0.1 1.9 1 1 0 1 1 1 1 NACHT domain DUF815 PF05673.13 EDP42036.1 - 0.00051 19.3 0.1 0.0069 15.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 EDP42036.1 - 0.00076 19.4 0.1 0.0019 18.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDP42036.1 - 0.0012 18.5 0.4 0.1 12.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain TsaE PF02367.17 EDP42036.1 - 0.0012 18.8 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 EDP42036.1 - 0.0013 19.1 0.2 0.015 15.6 0.2 2.2 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDP42036.1 - 0.0014 19.0 0.0 0.0028 18.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.6 EDP42036.1 - 0.0026 17.5 0.0 0.0064 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDP42036.1 - 0.003 17.8 0.0 0.0061 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EDP42036.1 - 0.0033 17.2 0.2 0.0074 16.0 0.1 1.8 2 1 0 2 2 1 1 Cytidylate kinase Rad17 PF03215.15 EDP42036.1 - 0.0072 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain TIP49 PF06068.13 EDP42036.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EDP42036.1 - 0.021 14.2 0.0 0.061 12.7 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDP42036.1 - 0.022 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain MMR_HSR1 PF01926.23 EDP42036.1 - 0.022 14.8 0.0 0.44 10.6 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EDP42036.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_3 PF07726.11 EDP42036.1 - 0.035 14.0 0.0 0.066 13.1 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 EDP42036.1 - 0.037 13.2 0.0 4.6 6.4 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain ABC_tran PF00005.27 EDP42036.1 - 0.044 14.3 0.0 0.074 13.6 0.0 1.5 1 1 0 1 1 1 0 ABC transporter PhoH PF02562.16 EDP42036.1 - 0.053 13.0 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein CPT PF07931.12 EDP42036.1 - 0.064 13.1 0.1 0.14 11.9 0.0 1.6 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 EDP42036.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 EDP42036.1 - 0.097 13.1 0.0 0.21 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EDP42036.1 - 0.13 11.6 0.0 0.63 9.3 0.0 1.8 1 1 1 2 2 2 0 KaiC AAA_13 PF13166.6 EDP42036.1 - 0.14 10.8 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 EDP42036.1 - 0.16 11.3 0.0 0.46 9.8 0.0 1.6 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain DUF2075 PF09848.9 EDP42036.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 EDP42036.1 - 0.2 12.1 0.0 0.38 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 EDP42037.1 - 1.2e-10 41.7 0.2 0.002 18.9 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42037.1 - 6.5e-05 23.2 0.2 0.5 10.7 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 EDP42037.1 - 0.016 15.0 0.0 0.12 12.1 0.0 2.1 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain WD40_like PF17005.5 EDP42037.1 - 0.091 12.1 0.5 1.8 7.8 0.1 2.2 2 1 1 3 3 3 0 WD40-like domain PP2C PF00481.21 EDP42038.1 - 7.4e-58 196.2 0.0 1.3e-57 195.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C HlyIII PF03006.20 EDP42039.1 - 4.8e-52 176.9 19.1 6.4e-52 176.5 19.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.11 EDP42039.1 - 4.6 6.7 5.7 3.1 7.2 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) TAF8_C PF10406.9 EDP42040.1 - 2.9e-14 53.3 0.1 7e-14 52.1 0.1 1.7 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term E1-E2_ATPase PF00122.20 EDP42041.1 - 3e-34 118.1 11.6 1.8e-32 112.4 0.3 3.8 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDP42041.1 - 1.1e-27 96.9 5.2 1.1e-27 96.9 5.2 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EDP42041.1 - 1.2e-19 70.2 0.0 2.6e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDP42041.1 - 1.6e-18 67.8 0.0 2.4e-16 60.7 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDP42041.1 - 4.1e-17 61.6 0.0 2.6e-16 59.1 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDP42041.1 - 0.00023 21.0 0.1 0.0049 16.6 0.4 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EDP42041.1 - 0.092 12.6 1.5 0.24 11.3 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) Rdx PF10262.9 EDP42043.1 - 2e-20 72.8 0.0 3.8e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Rdx family DUF2613 PF11021.8 EDP42043.1 - 0.008 16.3 6.6 0.083 13.0 6.6 2.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2613) SIR2 PF02146.17 EDP42045.1 - 2.4e-26 92.7 0.1 1.3e-18 67.5 0.0 3.3 3 0 0 3 3 3 2 Sir2 family FAM70 PF14967.6 EDP42045.1 - 3.1 7.2 4.7 7.2 6.0 4.7 1.5 1 0 0 1 1 1 0 FAM70 protein ETF PF01012.21 EDP42046.1 - 2.1e-45 154.8 4.7 3.4e-45 154.2 4.7 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EDP42046.1 - 2.7e-33 113.8 1.7 3.7e-33 113.4 0.2 2.0 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ANAPC4 PF12896.7 EDP42047.1 - 2.5e-31 108.8 0.1 3.7e-31 108.2 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EDP42047.1 - 0.11 12.8 0.0 0.43 10.9 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ku PF02735.16 EDP42048.1 - 1.2e-25 90.5 0.0 2.2e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EDP42048.1 - 0.092 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Ku C terminal domain like Glyco_trans_1_4 PF13692.6 EDP42049.1 - 2e-05 25.0 0.0 3.8e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDP42049.1 - 0.012 15.6 6.1 0.02 14.9 6.1 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Ufd2P_core PF10408.9 EDP42050.1 - 9e-202 672.0 0.0 1.1e-201 671.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EDP42050.1 - 4.3e-25 87.7 0.2 1.4e-24 86.0 0.2 2.0 1 0 0 1 1 1 1 U-box domain DivIC PF04977.15 EDP42050.1 - 0.067 13.0 0.2 0.3 10.9 0.2 2.1 1 0 0 1 1 1 0 Septum formation initiator ABC_tran_CTD PF16326.5 EDP42050.1 - 0.21 11.9 1.7 3.4 8.0 0.7 2.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain Pox_A_type_inc PF04508.12 EDP42050.1 - 0.22 11.4 3.9 0.59 10.1 3.9 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat FlaC_arch PF05377.11 EDP42050.1 - 1.3 9.5 3.3 30 5.1 0.0 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) EIF_2_alpha PF07541.12 EDP42051.1 - 5.1e-38 129.7 0.2 1.5e-37 128.2 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EDP42051.1 - 2.7e-13 50.0 0.2 7.7e-13 48.6 0.2 1.8 1 0 0 1 1 1 1 S1 RNA binding domain bMG3 PF11974.8 EDP42051.1 - 0.021 14.8 0.0 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain Amidohydro_1 PF01979.20 EDP42051.1 - 0.034 13.5 0.2 0.047 13.0 0.2 1.2 1 0 0 1 1 1 0 Amidohydrolase family DUF4453 PF14627.6 EDP42051.1 - 0.077 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) AP_endonuc_2 PF01261.24 EDP42051.1 - 0.13 11.7 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Cpn60_TCP1 PF00118.24 EDP42052.1 - 7.4e-152 506.4 2.3 8.6e-152 506.2 2.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.21 EDP42052.1 - 0.011 15.9 0.6 0.18 11.9 0.1 2.9 3 0 0 3 3 3 0 Resolvase, N terminal domain Pro_isomerase PF00160.21 EDP42053.1 - 8.8e-49 165.8 0.0 1.6e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EDP42053.1 - 4e-11 43.3 0.4 0.0067 17.3 0.0 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42053.1 - 0.033 14.5 0.0 1.7 9.0 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP42053.1 - 0.036 13.0 0.9 0.35 9.8 0.3 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SGL PF08450.12 EDP42053.1 - 0.098 12.2 0.0 4.8 6.7 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region BCNT PF07572.12 EDP42055.1 - 1.3e-28 98.9 0.3 1.8e-28 98.4 0.3 1.2 1 0 0 1 1 1 1 Bucentaur or craniofacial development Presenilin PF01080.17 EDP42056.1 - 0.37 9.5 2.4 0.17 10.6 0.1 1.6 2 0 0 2 2 2 0 Presenilin zf-RING_5 PF14634.6 EDP42057.1 - 0.65 10.0 4.7 4 7.5 2.8 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EDP42057.1 - 0.77 10.1 6.2 0.64 10.4 3.4 2.1 2 0 0 2 2 2 0 Ring finger domain Na_Ca_ex PF01699.24 EDP42058.1 - 5.2e-16 59.0 39.0 4.7e-12 46.1 13.3 3.9 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 EDP42058.1 - 2.1e-10 41.1 14.0 2.1e-10 41.1 14.0 4.2 4 0 0 4 4 4 1 Inner membrane component domain ECM1 PF05782.11 EDP42058.1 - 0.19 10.6 1.2 0.28 10.1 1.2 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) PufQ PF05398.11 EDP42058.1 - 0.35 11.0 1.6 17 5.6 0.4 2.9 2 0 0 2 2 2 0 PufQ cytochrome subunit CCB1 PF12046.8 EDP42058.1 - 0.66 9.3 2.6 3.7 6.9 0.4 2.7 3 0 0 3 3 3 0 Cofactor assembly of complex C subunit B Otopetrin PF03189.13 EDP42058.1 - 0.98 8.2 6.1 0.088 11.6 0.9 1.8 2 0 0 2 2 2 0 Otopetrin Semialdhyde_dhC PF02774.18 EDP42059.1 - 4.1e-39 134.5 0.0 5.5e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EDP42059.1 - 7.1e-27 94.3 0.0 1.8e-26 92.9 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDP42059.1 - 0.021 15.0 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ILVD_EDD PF00920.21 EDP42060.1 - 2.4e-205 683.0 0.1 2.8e-205 682.8 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family PS_Dcarbxylase PF02666.15 EDP42061.1 - 2.1e-51 174.3 0.0 3.2e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EDP42061.1 - 1.2e-20 73.7 0.0 1.5e-18 66.9 0.1 3.1 3 0 0 3 3 3 1 C2 domain EF-hand_1 PF00036.32 EDP42061.1 - 0.00027 20.3 0.1 0.0007 19.0 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EDP42061.1 - 0.00084 19.1 0.1 0.0026 17.6 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EDP42061.1 - 0.026 15.0 0.1 0.065 13.7 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair Cytochrom_C PF00034.21 EDP42062.1 - 4.3e-11 43.8 0.0 6.5e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EDP42062.1 - 1.6e-08 34.8 1.7 2.2e-07 31.1 1.7 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EDP42062.1 - 0.00099 18.8 0.2 0.0076 16.0 0.1 2.0 2 0 0 2 2 2 1 Cytochrome c-550 domain CCP_MauG PF03150.14 EDP42062.1 - 0.012 16.3 0.0 0.013 16.1 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase GATA PF00320.27 EDP42063.1 - 7e-15 54.3 2.5 1.3e-14 53.5 2.5 1.4 1 0 0 1 1 1 1 GATA zinc finger Ribosomal_L15e PF00827.17 EDP42064.1 - 6.4e-92 306.5 8.7 7.5e-92 306.3 8.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 Ribosomal_L18_c PF14204.6 EDP42065.1 - 9.4e-36 122.6 6.4 1.1e-35 122.4 6.4 1.1 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.6 EDP42065.1 - 0.00082 19.5 0.2 0.65 10.3 0.0 2.8 2 1 0 2 2 2 2 Threonine synthase N terminus MtrA PF04208.14 EDP42065.1 - 0.048 13.3 0.1 0.066 12.8 0.1 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A Methyltransf_4 PF02390.17 EDP42065.1 - 0.092 12.2 0.5 0.14 11.6 0.5 1.3 1 0 0 1 1 1 0 Putative methyltransferase His_Phos_2 PF00328.22 EDP42066.1 - 8.1e-42 143.9 1.0 1e-41 143.6 1.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.22 EDP42067.1 - 1.2e-47 163.1 0.0 1.5e-47 162.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) B12D PF06522.11 EDP42068.1 - 1.6e-13 50.2 0.0 1.6e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit ERG4_ERG24 PF01222.17 EDP42069.1 - 3.9e-144 480.6 8.6 4.5e-144 480.4 8.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EDP42069.1 - 2e-06 27.5 1.0 4.4e-06 26.4 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EDP42069.1 - 0.00032 21.1 0.0 0.002 18.5 0.0 2.5 1 1 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.14 EDP42069.1 - 0.019 15.4 0.0 0.069 13.6 0.0 1.9 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family NAD_binding_8 PF13450.6 EDP42070.1 - 1.6e-10 41.0 0.1 0.00029 21.0 0.2 2.2 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDP42070.1 - 0.00084 19.0 0.1 0.0011 18.6 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EDP42070.1 - 0.0023 17.3 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Osw5 PF17062.5 EDP42070.1 - 0.0026 17.8 2.5 0.0054 16.8 2.5 1.5 1 0 0 1 1 1 1 Outer spore wall 5 Pyr_redox_2 PF07992.14 EDP42070.1 - 0.051 12.8 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDP42070.1 - 0.053 12.8 0.1 0.084 12.1 0.1 1.2 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EDP42070.1 - 0.23 10.5 0.1 0.31 10.1 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Prenylcys_lyase PF07156.14 EDP42071.1 - 1.6e-21 76.8 0.0 1.9e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase Cofilin_ADF PF00241.20 EDP42072.1 - 8.1e-44 148.3 0.4 9.2e-44 148.1 0.4 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein dCache_2 PF08269.11 EDP42072.1 - 0.031 13.4 0.1 0.047 12.9 0.1 1.2 1 0 0 1 1 1 0 Cache domain LPP20 PF02169.16 EDP42072.1 - 0.093 13.1 0.3 0.21 12.0 0.1 1.6 2 0 0 2 2 2 0 LPP20 lipoprotein Ras PF00071.22 EDP42073.1 - 1.3e-56 190.7 0.0 1.5e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP42073.1 - 3.2e-22 79.0 0.0 4.5e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP42073.1 - 7e-07 28.9 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EDP42073.1 - 0.00088 18.7 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EDP42073.1 - 0.18 11.1 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GDA1_CD39 PF01150.17 EDP42074.1 - 7.2e-92 308.2 0.0 1e-91 307.8 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EDP42074.1 - 0.0094 15.4 0.1 0.13 11.7 0.0 2.1 2 0 0 2 2 2 1 Ppx/GppA phosphatase family DcpS_C PF11969.8 EDP42075.1 - 1.6e-26 93.0 0.2 3.8e-26 91.8 0.1 1.6 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 EDP42075.1 - 5.7e-23 81.7 0.0 9.2e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal TFCD_C PF12612.8 EDP42076.1 - 1.7e-18 67.2 0.4 9.7e-18 64.7 0.1 2.5 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal B56 PF01603.20 EDP42076.1 - 0.017 14.1 0.3 2.9 6.8 0.1 2.4 3 0 0 3 3 3 0 Protein phosphatase 2A regulatory B subunit (B56 family) Vac14_Fab1_bd PF12755.7 EDP42076.1 - 0.027 15.0 0.0 0.21 12.2 0.0 2.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Cnd3 PF12719.7 EDP42076.1 - 0.053 12.7 2.3 0.11 11.6 0.7 2.3 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 EDP42076.1 - 0.063 13.5 0.5 1 9.6 0.1 3.0 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EDP42076.1 - 0.24 11.8 0.1 0.24 11.8 0.1 6.7 8 0 0 8 8 8 0 HEAT repeat TerB PF05099.13 EDP42076.1 - 0.27 11.2 4.3 6.6 6.7 1.4 2.6 2 0 0 2 2 2 0 Tellurite resistance protein TerB HEAT_PBS PF03130.16 EDP42076.1 - 0.46 11.3 12.1 1.2 10.0 1.0 5.5 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Hpt PF01627.23 EDP42077.1 - 2.2e-07 31.1 0.0 2.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Hpt domain MINDY_DUB PF04424.13 EDP42078.1 - 1.3e-27 96.1 0.0 2.1e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase DUF2510 PF10708.9 EDP42078.1 - 0.11 12.2 0.3 0.55 10.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) Peptidase_M24 PF00557.24 EDP42079.1 - 3.3e-20 72.7 0.9 8.8e-20 71.3 0.9 1.6 1 1 0 1 1 1 1 Metallopeptidase family M24 Pkinase PF00069.25 EDP42080.1 - 1.7e-38 132.6 0.0 3.2e-38 131.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42080.1 - 2.2e-11 43.6 0.0 3.5e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP42080.1 - 2.1e-05 24.6 1.7 0.00018 21.5 0.0 3.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EDP42080.1 - 0.0018 17.9 0.0 0.0039 16.8 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinetochor_Ybp2 PF08568.10 EDP42080.1 - 0.085 11.3 0.0 0.59 8.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family, YAP/Alf4/glomulin Haspin_kinase PF12330.8 EDP42080.1 - 0.2 10.6 0.0 0.41 9.5 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain AAA_2 PF07724.14 EDP42081.1 - 4.8e-46 157.0 0.0 2.5e-42 144.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDP42081.1 - 1.3e-30 105.4 4.3 7.5e-30 102.9 0.1 2.5 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EDP42081.1 - 9.1e-27 92.9 1.4 2e-26 91.8 0.1 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EDP42081.1 - 1.8e-19 70.5 0.0 5e-10 39.9 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDP42081.1 - 1.8e-12 47.4 0.2 2.6e-07 30.7 0.0 3.3 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EDP42081.1 - 6.3e-09 35.8 0.1 1.1e-06 28.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EDP42081.1 - 7.1e-06 26.1 0.0 0.031 14.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDP42081.1 - 1.4e-05 25.4 2.1 0.19 12.0 0.1 4.5 3 2 0 3 3 3 2 AAA domain AAA_7 PF12775.7 EDP42081.1 - 1.4e-05 24.7 0.0 0.26 10.8 0.0 3.1 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_16 PF13191.6 EDP42081.1 - 3.6e-05 24.2 8.7 0.00058 20.3 0.1 4.2 3 2 1 5 5 4 1 AAA ATPase domain ATPase_2 PF01637.18 EDP42081.1 - 8.6e-05 22.6 2.8 0.35 10.8 0.0 3.2 4 0 0 4 4 3 2 ATPase domain predominantly from Archaea TniB PF05621.11 EDP42081.1 - 0.00029 20.3 0.0 0.017 14.6 0.0 2.9 2 1 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 EDP42081.1 - 0.00075 19.3 0.0 0.16 11.7 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EDP42081.1 - 0.00087 19.7 0.1 0.59 10.5 0.0 2.8 2 1 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 EDP42081.1 - 0.0011 18.7 0.9 0.056 13.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain SRP54 PF00448.22 EDP42081.1 - 0.0017 18.0 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 EDP42081.1 - 0.0018 17.7 1.1 3.5 7.0 0.1 3.6 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDP42081.1 - 0.0028 17.9 1.3 3.6 7.8 0.0 4.1 3 1 0 4 4 3 1 AAA domain AAA_18 PF13238.6 EDP42081.1 - 0.0046 17.5 0.0 2.1 8.9 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_6 PF12774.7 EDP42081.1 - 0.0078 15.2 0.0 0.39 9.6 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EDP42081.1 - 0.0079 16.2 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EDP42081.1 - 0.0082 16.1 0.2 0.49 10.3 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA_23 PF13476.6 EDP42081.1 - 0.0098 16.4 5.9 17 5.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDP42081.1 - 0.0099 15.2 1.3 0.23 10.7 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin DNA_pol3_delta2 PF13177.6 EDP42081.1 - 0.015 15.1 0.1 1.2 8.9 0.0 3.5 3 1 0 3 3 3 0 DNA polymerase III, delta subunit Roc PF08477.13 EDP42081.1 - 0.015 15.5 0.0 1.8 8.8 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 EDP42081.1 - 0.018 15.4 0.4 9.7 6.5 0.0 3.9 5 0 0 5 5 4 0 AAA domain AAA_24 PF13479.6 EDP42081.1 - 0.038 13.7 0.0 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EDP42081.1 - 0.055 13.3 0.1 0.65 9.9 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EDP42081.1 - 0.065 13.1 0.1 0.91 9.4 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase ResIII PF04851.15 EDP42081.1 - 0.068 13.2 0.1 4.2 7.3 0.0 3.2 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 EDP42081.1 - 0.072 13.3 0.0 9.4 6.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP42081.1 - 0.22 12.0 3.1 33 5.0 0.0 3.5 2 1 1 3 3 3 0 ABC transporter TIP49 PF06068.13 EDP42081.1 - 0.28 10.3 8.4 4.7 6.3 0.1 4.1 3 1 2 5 5 5 0 TIP49 P-loop domain ATP_bind_1 PF03029.17 EDP42081.1 - 0.3 10.8 1.0 10 5.8 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein YlqD PF11068.8 EDP42081.1 - 1 9.7 8.0 3.3 8.1 7.3 2.2 2 0 0 2 2 2 0 YlqD protein BCIP PF13862.6 EDP42082.1 - 8.1e-19 68.2 0.0 1.2e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 p21-C-terminal region-binding protein NIF PF03031.18 EDP42083.1 - 1.3e-54 184.2 0.1 1.8e-54 183.7 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PRK PF00485.18 EDP42084.1 - 0.013 15.2 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family RIBIOP_C PF04950.12 EDP42085.1 - 4.3e-97 325.1 0.0 4.3e-97 325.1 0.0 2.2 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDP42085.1 - 2.3e-31 107.7 0.0 1e-30 105.6 0.0 2.2 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 EDP42085.1 - 5e-05 23.7 0.0 5e-05 23.7 0.0 3.2 4 1 0 4 4 1 1 AAA ATPase domain AAA_22 PF13401.6 EDP42085.1 - 9.7e-05 22.7 0.0 0.00041 20.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EDP42085.1 - 0.0015 18.6 0.1 0.0071 16.4 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EDP42085.1 - 0.0022 18.2 3.3 0.017 15.3 0.0 3.1 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EDP42085.1 - 0.0025 17.4 2.9 0.1 12.1 0.0 3.3 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EDP42085.1 - 0.0044 17.5 0.0 0.0044 17.5 0.0 2.9 3 0 0 3 3 2 1 ABC transporter AAA PF00004.29 EDP42085.1 - 0.0045 17.4 0.0 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EDP42085.1 - 0.0047 16.9 1.3 0.0066 16.4 0.0 1.9 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDP42085.1 - 0.0056 17.1 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EDP42085.1 - 0.012 15.7 0.1 0.036 14.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDP42085.1 - 0.012 15.2 0.6 0.32 10.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDP42085.1 - 0.012 15.2 0.1 0.03 13.9 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EDP42085.1 - 0.016 14.4 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain PduV-EutP PF10662.9 EDP42085.1 - 0.019 14.7 0.1 0.051 13.3 0.1 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EDP42085.1 - 0.021 14.7 0.0 0.048 13.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EDP42085.1 - 0.054 13.7 0.1 0.054 13.7 0.1 2.7 4 0 0 4 4 1 0 AAA domain MobB PF03205.14 EDP42085.1 - 0.055 13.4 0.2 0.19 11.6 0.1 2.1 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 EDP42085.1 - 0.066 12.8 0.2 0.34 10.5 0.1 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 EDP42085.1 - 0.081 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EDP42085.1 - 0.11 12.2 1.5 0.2 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EDP42085.1 - 0.12 12.6 0.0 0.12 12.6 0.0 2.4 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EDP42085.1 - 0.15 11.9 0.5 0.31 10.9 0.5 1.5 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 EDP42085.1 - 0.38 10.6 0.0 0.38 10.6 0.0 2.5 3 0 0 3 3 2 0 RsgA GTPase Ribosomal_L23eN PF03939.13 EDP42085.1 - 0.45 10.8 6.3 5.6 7.3 0.2 2.7 2 0 0 2 2 2 0 Ribosomal protein L23, N-terminal domain AAA_18 PF13238.6 EDP42085.1 - 0.58 10.7 0.0 0.58 10.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 EDP42085.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.6 4 0 0 4 4 2 0 AAA domain PCC_BT PF18140.1 EDP42085.1 - 1.8 8.9 6.6 3.8 7.9 0.1 2.7 2 0 0 2 2 2 0 Propionyl-coenzyme A carboxylase BT domain ADH_zinc_N PF00107.26 EDP42086.1 - 5.2e-10 39.4 0.0 7.8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AA_permease PF00324.21 EDP42087.1 - 2e-125 419.1 43.5 2.3e-125 418.9 43.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDP42087.1 - 6.4e-31 107.6 45.2 8.5e-31 107.2 45.2 1.1 1 0 0 1 1 1 1 Amino acid permease Pyr_redox_2 PF07992.14 EDP42088.1 - 5.7e-40 137.4 0.0 8.1e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP42088.1 - 1.7e-09 38.1 0.0 1.4e-06 28.8 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_6 PF13405.6 EDP42088.1 - 2.6e-08 33.2 0.5 0.00028 20.6 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EDP42088.1 - 1.8e-07 30.2 0.4 5.7e-05 22.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EDP42088.1 - 4.8e-06 26.9 0.2 1.1e-05 25.8 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EDP42088.1 - 5.9e-06 25.5 0.9 7.7e-05 22.0 0.2 2.5 2 0 0 2 2 2 1 EF hand Pyr_redox_3 PF13738.6 EDP42088.1 - 0.013 14.8 2.7 1.1 8.5 3.9 2.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EDP42088.1 - 0.045 14.2 0.0 0.17 12.3 0.0 2.2 1 1 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EDP42088.1 - 0.093 12.7 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Syja_N PF02383.18 EDP42089.1 - 1.2e-59 202.3 0.0 1.8e-59 201.7 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EDP42089.1 - 1.6e-07 31.1 0.0 2.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PI_PP_I PF18363.1 EDP42090.1 - 0.64 10.2 4.6 1.1 9.5 0.2 3.5 2 2 0 3 3 3 0 Phosphoinositide phosphatase insertion domain Cas_Csn2 PF09711.10 EDP42090.1 - 0.87 9.2 4.7 4.9 6.8 0.4 2.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csn2) Fib_alpha PF08702.10 EDP42090.1 - 7 6.8 59.9 0.18 12.0 2.6 7.2 4 1 3 7 7 7 0 Fibrinogen alpha/beta chain family PHD PF00628.29 EDP42091.1 - 5.1e-08 32.7 9.2 8.8e-08 31.9 9.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDP42091.1 - 0.015 14.8 7.0 0.028 14.0 7.0 1.4 1 0 0 1 1 1 0 PHD-finger zf-CW PF07496.15 EDP42091.1 - 0.022 14.8 2.3 0.043 13.8 2.3 1.5 1 0 0 1 1 1 0 CW-type Zinc Finger FYVE_2 PF02318.16 EDP42091.1 - 0.028 14.6 1.7 0.043 14.0 1.7 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger Peptidase_M16 PF00675.20 EDP42092.1 - 5.1e-39 133.6 0.0 8.3e-39 132.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDP42092.1 - 6.9e-39 133.7 0.0 1.2e-38 133.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Hydrolase_4 PF12146.8 EDP42093.1 - 3.9e-26 91.8 0.1 6.6e-26 91.0 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDP42093.1 - 5.7e-11 43.4 0.1 8.7e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDP42093.1 - 0.00012 21.8 0.2 0.00048 19.8 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EDP42093.1 - 0.0055 16.3 0.0 2.2 7.8 0.0 2.5 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EDP42093.1 - 0.0066 16.0 0.0 2.7 7.5 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EDP42093.1 - 0.048 13.1 0.0 0.36 10.3 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Linker_histone PF00538.19 EDP42094.1 - 8.7e-06 26.0 0.0 2.4e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family Pkinase PF00069.25 EDP42095.1 - 1.4e-07 31.2 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EDP42095.1 - 9.9e-07 28.9 0.1 2.2e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP42095.1 - 0.005 15.7 0.1 0.0084 14.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDP42095.1 - 0.0079 15.6 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDP42095.1 - 0.033 13.2 0.1 0.052 12.6 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 EDP42095.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase IPK PF03770.16 EDP42097.1 - 1.1e-41 142.9 0.0 2e-41 142.0 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Ribosomal_L14e PF01929.17 EDP42098.1 - 7.6e-24 84.0 4.7 5e-22 78.2 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L14 Ribosomal_S8 PF00410.19 EDP42099.1 - 6.6e-21 74.6 0.0 1.2e-20 73.7 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S17e PF00833.18 EDP42100.1 - 3.9e-23 81.7 0.0 4.8e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal S17 Glyco_hydro_8 PF01270.17 EDP42101.1 - 1.4e-20 73.4 0.1 9.9e-20 70.6 0.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 8 DNA_pol_A_exo1 PF01612.20 EDP42102.1 - 1.3e-18 67.3 0.0 1.8e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease RAC_head PF16717.5 EDP42103.1 - 8.9e-17 61.9 0.5 8.9e-17 61.9 0.5 3.1 4 0 0 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 EDP42103.1 - 5.5e-16 58.5 0.2 5.5e-16 58.5 0.2 1.9 2 0 0 2 2 2 1 DnaJ domain AAA_21 PF13304.6 EDP42103.1 - 0.2 11.4 2.5 0.29 10.9 2.5 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system LMBR1 PF04791.16 EDP42103.1 - 2.1 7.1 4.4 2.9 6.7 4.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Presenilin PF01080.17 EDP42103.1 - 2.4 6.8 7.5 4 6.1 7.5 1.3 1 0 0 1 1 1 0 Presenilin AAA_23 PF13476.6 EDP42103.1 - 3.5 8.1 13.7 0.54 10.7 9.0 1.9 2 0 0 2 2 2 0 AAA domain DUF5427 PF10310.9 EDP42103.1 - 8.8 5.2 19.4 15 4.4 19.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) tRNA-synt_2b PF00587.25 EDP42104.1 - 2.3e-35 122.2 0.0 3.6e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EDP42104.1 - 7.1e-13 48.7 10.1 9.5e-12 45.1 7.2 2.6 2 1 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain YqfD PF06898.11 EDP42104.1 - 0.1 11.4 2.8 0.16 10.8 2.8 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD ProRS-C_1 PF09180.11 EDP42105.1 - 3.1e-27 94.6 0.2 5.8e-27 93.7 0.2 1.5 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EDP42105.1 - 1.1e-17 64.5 0.0 2.3e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDP42105.1 - 2.8e-17 62.7 0.1 2.8e-16 59.4 0.0 2.7 3 0 0 3 3 3 1 Anticodon binding domain tRNA_edit PF04073.15 EDP42105.1 - 1.1e-12 48.1 0.3 2.4e-12 47.0 0.3 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain SRP19 PF01922.17 EDP42106.1 - 4.1e-20 72.5 0.0 6.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein DUF3617 PF12276.8 EDP42106.1 - 0.044 14.1 0.1 0.061 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) zf-CCHC PF00098.23 EDP42107.1 - 9.5e-52 170.9 57.8 2.1e-08 33.9 2.6 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EDP42107.1 - 1.1e-13 50.6 41.8 0.0045 16.7 0.5 7.0 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 EDP42107.1 - 1.1e-11 44.5 36.2 0.03 14.3 0.3 7.1 2 2 5 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 EDP42107.1 - 0.0016 18.1 37.2 0.52 10.1 0.3 7.0 6 1 1 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 EDP42107.1 - 0.021 14.7 48.5 0.076 12.9 4.7 7.0 5 2 2 7 7 7 0 Zinc knuckle zf-CCHC_2 PF13696.6 EDP42107.1 - 0.048 13.5 48.8 0.29 11.0 1.2 7.3 7 0 0 7 7 7 0 Zinc knuckle HscB_4_cys PF18256.1 EDP42107.1 - 0.84 9.5 0.1 0.84 9.5 0.1 7.3 7 1 0 7 7 7 0 Co-chaperone HscB tetracysteine metal binding motif DnaJ_CXXCXGXG PF00684.19 EDP42107.1 - 1.3 9.4 40.7 0.12 12.8 11.4 4.3 1 1 3 4 4 4 0 DnaJ central domain SKN1 PF03935.15 EDP42108.1 - 1.4e-170 568.1 3.0 2.1e-170 567.4 3.0 1.2 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) DEAD PF00270.29 EDP42109.1 - 1.9e-19 70.1 0.0 1.5e-18 67.1 0.0 2.4 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42109.1 - 0.0002 21.7 0.0 0.0004 20.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42109.1 - 0.0031 17.5 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Fer2 PF00111.27 EDP42110.1 - 4.2e-11 42.6 0.7 6.4e-11 42.1 0.7 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Sugar_tr PF00083.24 EDP42111.1 - 1.6e-55 188.8 12.9 2.2e-55 188.4 12.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP42111.1 - 0.00023 20.2 31.5 0.019 13.9 4.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 EDP42111.1 - 0.024 14.4 0.5 0.024 14.4 0.5 3.0 3 0 0 3 3 3 0 Bacteriophage holin family HP1 DUF2070 PF09843.9 EDP42111.1 - 1.7 6.9 6.2 2.2 6.5 6.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) WD40 PF00400.32 EDP42112.1 - 2.3e-17 63.0 12.2 1.7e-05 25.5 0.3 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42112.1 - 7e-16 58.3 6.8 0.0002 21.6 0.0 5.9 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP42112.1 - 6.4e-05 22.1 1.1 0.0031 16.5 0.0 3.0 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDP42112.1 - 7.5e-05 22.7 0.0 0.00023 21.1 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EDP42112.1 - 0.00074 17.7 0.4 0.029 12.4 0.3 2.3 2 0 0 2 2 2 2 IKI3 family Nbas_N PF15492.6 EDP42112.1 - 0.061 12.6 0.5 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Pkinase PF00069.25 EDP42113.1 - 4.5e-59 200.0 0.0 5.2e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42113.1 - 3.9e-26 91.9 0.0 5.2e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP42113.1 - 0.03 13.3 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDP42113.1 - 0.036 14.0 0.1 0.073 13.0 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP42113.1 - 0.051 12.9 0.0 0.081 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 EDP42113.1 - 0.087 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Utp12 PF04003.12 EDP42114.1 - 4.3e-22 78.5 0.3 7.3e-22 77.7 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 EDP42114.1 - 0.00031 21.5 0.0 0.0048 17.7 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ATP12 PF07542.11 EDP42115.1 - 0.096 12.8 0.4 0.22 11.6 0.4 1.6 1 0 0 1 1 1 0 ATP12 chaperone protein Cut8 PF08559.10 EDP42116.1 - 1.4e-14 54.3 0.0 3.1e-14 53.2 0.0 1.5 2 0 0 2 2 2 1 Cut8, nuclear proteasome tether protein PRELI PF04707.14 EDP42117.1 - 2.4e-17 63.2 0.0 3e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family Suf PF05843.14 EDP42118.1 - 9.5e-71 239.2 0.0 2.5e-69 234.5 0.0 3.0 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EDP42118.1 - 2.5e-05 24.7 4.6 0.94 10.5 0.0 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42118.1 - 0.019 15.4 5.0 3.4 8.3 0.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat HSCB_C PF07743.13 EDP42118.1 - 5.3 7.6 9.4 16 6.0 3.6 3.5 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain TPR_1 PF00515.28 EDP42119.1 - 1.5e-43 144.9 18.3 1.9e-05 24.3 0.1 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42119.1 - 7.6e-39 128.7 17.8 0.0011 18.9 0.0 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 EDP42119.1 - 1.6e-32 111.2 15.6 3.3e-17 62.2 3.1 3.4 4 0 0 4 4 3 2 STI1 domain TPR_12 PF13424.6 EDP42119.1 - 1.8e-24 85.8 11.3 6.6e-09 35.9 0.0 6.7 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42119.1 - 2.8e-23 80.1 19.7 0.00077 19.5 0.0 8.5 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDP42119.1 - 7.5e-20 70.3 13.9 5e-06 26.1 0.0 7.2 6 2 1 7 7 7 5 TPR repeat TPR_14 PF13428.6 EDP42119.1 - 2.7e-18 65.1 1.9 0.0073 17.0 0.0 8.2 4 2 4 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42119.1 - 5e-18 65.5 9.0 0.00027 21.5 0.3 6.2 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42119.1 - 1.7e-15 57.2 8.6 0.0015 19.0 0.0 6.6 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 EDP42119.1 - 5.7e-13 48.3 8.9 0.028 14.3 0.0 8.7 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42119.1 - 1.1e-12 47.0 5.0 0.026 14.5 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP42119.1 - 2e-09 37.1 1.8 0.038 14.4 0.1 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDP42119.1 - 2.7e-08 33.8 1.2 0.18 11.9 0.0 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EDP42119.1 - 0.00035 20.0 3.2 0.036 13.4 0.0 3.3 3 0 0 3 3 3 1 MalT-like TPR region NARP1 PF12569.8 EDP42119.1 - 0.0058 15.6 16.7 0.0072 15.3 0.3 3.8 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 SprT-like PF10263.9 EDP42119.1 - 0.093 12.6 0.1 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 SprT-like family ANAPC3 PF12895.7 EDP42119.1 - 0.4 10.9 11.3 8.2 6.7 0.4 4.5 3 3 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EDP42119.1 - 2.4 9.0 16.7 76 4.3 0.4 7.7 10 0 0 10 10 10 0 Tetratricopeptide repeat RNA_pol_3_Rpc31 PF11705.8 EDP42120.1 - 1.8e-17 64.4 1.7 3.2e-17 63.6 1.7 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Zn_clus PF00172.18 EDP42121.1 - 1.8e-05 24.7 8.5 4e-05 23.6 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nup192 PF11894.8 EDP42122.1 - 3.6e-204 680.8 0.0 5.4e-204 680.3 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Urb2 PF10441.9 EDP42122.1 - 4.4 7.2 7.0 26 4.6 0.3 3.1 3 0 0 3 3 3 0 Urb2/Npa2 family Pyridoxal_deC PF00282.19 EDP42123.1 - 5e-93 311.8 0.0 5.8e-93 311.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF2269 PF10027.9 EDP42125.1 - 0.1 12.6 6.7 0.047 13.7 4.3 1.6 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2269) EI24 PF07264.11 EDP42126.1 - 1.3e-05 25.5 5.4 3.3e-05 24.2 5.2 1.8 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF4112 PF13430.6 EDP42126.1 - 0.15 12.3 0.1 0.72 10.2 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) Thioredoxin PF00085.20 EDP42127.1 - 2.8e-05 24.0 0.0 4.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Ovate PF04844.13 EDP42128.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional repressor, ovate TruB_N PF01509.18 EDP42129.1 - 3e-38 131.5 0.0 2.2e-36 125.4 0.0 2.1 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EDP42129.1 - 2.9e-07 30.6 0.0 6.9e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DGF-1_C PF11040.8 EDP42129.1 - 0.072 13.1 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Formyl_trans_N PF00551.19 EDP42130.1 - 4.2e-16 59.2 0.0 6.1e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EDP42130.1 - 1e-07 32.1 0.0 1.7e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain MWFE PF15879.5 EDP42130.1 - 0.11 12.7 1.4 0.12 12.6 0.1 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Ysc84 PF04366.12 EDP42131.1 - 9.7e-39 132.0 0.0 2.7e-38 130.6 0.0 1.7 2 0 0 2 2 2 1 Las17-binding protein actin regulator Esterase PF00756.20 EDP42132.1 - 9.3e-43 146.7 0.0 1.1e-42 146.4 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EDP42132.1 - 3.7e-05 23.3 0.0 5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EDP42132.1 - 0.0023 17.2 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EDP42132.1 - 0.0086 15.0 0.0 0.014 14.3 0.0 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Lipase_3 PF01764.25 EDP42132.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 EDP42132.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold DnaJ PF00226.31 EDP42133.1 - 0.0029 17.7 0.0 0.0063 16.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain CPBP PF02517.16 EDP42134.1 - 2.5e-18 66.2 0.8 4.9e-18 65.3 0.8 1.5 1 0 0 1 1 1 1 CPBP intramembrane metalloprotease YtxH PF12732.7 EDP42135.1 - 0.00044 20.7 4.2 0.24 12.0 4.2 2.1 1 1 0 1 1 1 1 YtxH-like protein DUF883 PF05957.13 EDP42135.1 - 0.00053 20.5 2.4 0.04 14.5 0.3 2.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF883) Nbl1_Borealin_N PF10444.9 EDP42135.1 - 0.005 16.5 0.0 0.095 12.4 0.0 2.1 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal Apolipoprotein PF01442.18 EDP42135.1 - 0.0082 16.0 3.2 0.014 15.3 3.2 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DivIVA PF05103.13 EDP42135.1 - 0.029 14.5 3.9 0.11 12.6 0.5 2.0 2 0 0 2 2 2 0 DivIVA protein Tape_meas_lam_C PF09718.10 EDP42135.1 - 0.07 13.3 5.2 0.16 12.2 0.5 2.5 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) V-ATPase_G_2 PF16999.5 EDP42135.1 - 0.28 11.6 5.0 1.6 9.2 0.6 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 EDP42135.1 - 1.9 8.6 10.4 58 3.8 10.4 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) YlqD PF11068.8 EDP42135.1 - 2 8.8 7.2 5.1 7.5 7.2 1.6 1 1 0 1 1 1 0 YlqD protein Alanine_zipper PF11839.8 EDP42135.1 - 4.7 7.6 13.6 12 6.4 3.4 2.7 1 1 1 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Inositol_P PF00459.25 EDP42136.1 - 2.2e-46 158.6 0.2 4.1e-45 154.4 0.2 2.0 1 1 0 1 1 1 1 Inositol monophosphatase family Importin_rep_5 PF18816.1 EDP42136.1 - 0.1 12.9 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Importin repeat AAA_5 PF07728.14 EDP42137.1 - 2.7e-67 225.0 0.0 1.8e-28 99.3 0.0 3.5 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDP42137.1 - 0.00061 19.7 0.0 0.15 11.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EDP42137.1 - 0.014 15.5 0.2 0.32 11.2 0.1 2.6 2 0 0 2 2 2 0 Midasin AAA lid domain AAA_16 PF13191.6 EDP42137.1 - 0.016 15.6 0.7 5.5 7.4 0.0 3.9 3 1 0 3 3 3 0 AAA ATPase domain AAA PF00004.29 EDP42137.1 - 0.12 12.8 0.0 0.33 11.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Raptor_N PF14538.6 EDP42138.1 - 5.7e-61 204.8 0.0 1.3e-60 203.6 0.0 1.7 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 EDP42138.1 - 5.9e-08 32.3 8.8 0.019 15.2 0.1 5.5 5 0 0 5 5 5 3 HEAT repeat WD40 PF00400.32 EDP42138.1 - 1.9e-06 28.5 13.8 0.51 11.3 0.1 6.8 7 0 0 7 7 7 2 WD domain, G-beta repeat Cnd1 PF12717.7 EDP42138.1 - 0.0022 18.0 0.3 0.058 13.4 0.0 2.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDP42138.1 - 0.0035 17.7 5.0 0.037 14.4 0.5 4.4 3 1 1 4 4 4 2 HEAT repeats Hira PF07569.11 EDP42138.1 - 0.19 11.4 0.6 16 5.1 0.0 2.5 2 0 0 2 2 2 0 TUP1-like enhancer of split HEAT_EZ PF13513.6 EDP42138.1 - 2.8 8.5 14.0 0.71 10.4 0.2 5.4 5 0 0 5 5 5 0 HEAT-like repeat NUDIX PF00293.28 EDP42139.1 - 0.11 12.5 0.0 0.35 10.9 0.0 1.8 1 0 0 1 1 1 0 NUDIX domain Torus PF16131.5 EDP42140.1 - 9.8e-08 32.7 0.3 1.2e-05 26.0 0.2 2.9 2 0 0 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 EDP42140.1 - 1.3e-06 28.7 9.4 1.3e-06 28.7 9.4 2.5 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EDP42140.1 - 5.3e-05 22.9 14.6 0.00012 21.8 5.5 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Ank_2 PF12796.7 EDP42140.1 - 0.00041 20.9 0.0 0.00076 20.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP42140.1 - 0.0013 19.2 0.0 0.0034 17.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) zf-CCCH PF00642.24 EDP42140.1 - 0.0018 18.1 12.1 0.11 12.4 2.5 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ank_3 PF13606.6 EDP42140.1 - 0.016 15.6 0.0 0.19 12.4 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EDP42140.1 - 0.031 14.6 0.1 0.32 11.4 0.1 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) zf_CCCH_4 PF18345.1 EDP42140.1 - 0.5 10.5 19.3 0.064 13.3 1.9 2.9 3 0 0 3 3 3 0 Zinc finger domain zf-CCCH_3 PF15663.5 EDP42140.1 - 0.64 10.3 2.6 26 5.1 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger containing family Pkinase PF00069.25 EDP42141.1 - 4e-70 236.2 0.0 4.7e-70 236.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42141.1 - 1.1e-31 110.0 0.0 1.4e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP42141.1 - 0.00018 21.6 0.1 0.00036 20.5 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDP42141.1 - 0.00044 19.9 0.3 0.00072 19.2 0.3 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EDP42141.1 - 0.00048 19.5 0.2 0.00082 18.8 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDP42141.1 - 0.00081 18.8 0.3 0.0056 16.0 0.1 2.0 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDP42141.1 - 0.0099 14.9 0.1 0.014 14.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain 3Beta_HSD PF01073.19 EDP42142.1 - 9e-57 192.2 0.0 5.3e-53 179.8 0.0 2.3 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP42142.1 - 1.3e-22 80.5 0.0 3.4e-22 79.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDP42142.1 - 6.6e-11 42.2 0.0 5.9e-09 35.8 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDP42142.1 - 3.1e-10 39.7 0.0 5.5e-09 35.6 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EDP42142.1 - 1e-08 34.6 0.0 1.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EDP42142.1 - 1.4e-08 34.8 0.0 1e-07 32.0 0.0 2.2 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EDP42142.1 - 0.0014 17.8 0.0 0.0026 16.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EDP42142.1 - 0.0064 16.4 0.3 0.028 14.3 0.3 1.9 1 1 0 1 1 1 1 KR domain zf-CHY PF05495.12 EDP42143.1 - 7.3e-11 42.4 9.6 1.3e-10 41.6 9.6 1.3 1 0 0 1 1 1 1 CHY zinc finger Zn_Tnp_IS1595 PF12760.7 EDP42143.1 - 0.0081 16.1 7.8 0.88 9.6 5.1 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain Cys_rich_KTR PF14205.6 EDP42143.1 - 0.015 15.1 8.7 0.93 9.3 0.1 2.4 1 1 1 2 2 2 0 Cysteine-rich KTR Anti-TRAP PF15777.5 EDP42143.1 - 0.028 14.4 2.6 0.14 12.1 0.0 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-FPG_IleRS PF06827.14 EDP42143.1 - 0.029 14.2 1.0 0.029 14.2 1.0 1.8 2 0 0 2 2 1 0 Zinc finger found in FPG and IleRS zf-LITAF-like PF10601.9 EDP42143.1 - 0.045 14.0 3.4 1.5 9.1 0.5 2.4 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EDP42143.1 - 0.048 13.8 2.1 0.048 13.8 2.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain HypA PF01155.19 EDP42143.1 - 0.066 13.2 0.9 0.066 13.2 0.9 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DpnI PF06044.12 EDP42143.1 - 0.11 12.1 3.0 0.29 10.7 0.5 2.3 1 1 2 3 3 3 0 Dam-replacing family DUF3797 PF12677.7 EDP42143.1 - 0.12 12.3 3.2 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) TF_Zn_Ribbon PF08271.12 EDP42143.1 - 0.24 10.9 5.2 0.77 9.3 1.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Elf1 PF05129.13 EDP42143.1 - 0.58 10.2 8.9 2.5 8.2 8.8 1.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Zn_ribbon_SprT PF17283.2 EDP42143.1 - 2.2 8.3 10.9 0.48 10.4 0.7 2.8 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zinc_ribbon_4 PF13717.6 EDP42143.1 - 2.5 8.1 11.9 7.2 6.6 0.1 3.5 3 1 0 3 3 3 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 EDP42143.1 - 5 7.0 8.3 3.4 7.5 2.7 2.6 2 1 0 2 2 2 0 A2L zinc ribbon domain ACBP PF00887.19 EDP42144.1 - 6.1e-32 109.7 0.8 8.6e-32 109.2 0.8 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein IFN-gamma PF00714.17 EDP42144.1 - 0.076 12.9 0.1 8.7 6.2 0.0 2.1 1 1 1 2 2 2 0 Interferon gamma DUF1145 PF06611.12 EDP42145.1 - 0.02 14.8 2.5 0.02 14.8 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1145) PIRT PF15099.6 EDP42145.1 - 0.056 13.0 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family YebF PF13995.6 EDP42145.1 - 0.057 13.4 0.0 0.099 12.7 0.0 1.3 1 0 0 1 1 1 0 YebF-like protein Ribophorin_II PF05817.14 EDP42145.1 - 0.16 10.5 2.3 0.39 9.2 2.2 1.6 1 1 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Methyltransf_23 PF13489.6 EDP42147.1 - 1.5e-13 50.9 0.0 1.2e-12 48.0 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP42147.1 - 5.3e-12 46.3 0.0 2.5e-11 44.2 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP42147.1 - 1.9e-11 44.5 0.0 2.3e-10 41.0 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP42147.1 - 2.4e-09 37.7 0.0 1.4e-08 35.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42147.1 - 1.7e-05 24.7 0.0 6.4e-05 22.8 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDP42147.1 - 3.6e-05 23.1 0.0 0.00074 18.8 0.0 2.1 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 EDP42147.1 - 0.0026 18.8 0.0 0.0065 17.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDP42147.1 - 0.003 17.1 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EDP42147.1 - 0.023 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ham1p_like PF01725.16 EDP42148.1 - 1.4e-29 103.4 0.1 4.2e-24 85.5 0.0 2.0 1 1 1 2 2 2 2 Ham1 family ANAPC4 PF12896.7 EDP42148.1 - 0.14 11.7 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 Glycos_transf_4 PF00953.21 EDP42149.1 - 3.9e-30 104.9 8.7 3.9e-30 104.9 8.7 2.3 3 0 0 3 3 3 1 Glycosyl transferase family 4 Herpes_VP19C PF03327.14 EDP42149.1 - 0.075 12.5 0.2 0.11 11.9 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus capsid shell protein VP19C DUF3951 PF13131.6 EDP42149.1 - 0.93 9.7 4.0 3.2 8.0 0.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) TPR_2 PF07719.17 EDP42150.1 - 4.6e-05 23.2 0.9 0.5 10.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP42150.1 - 0.00041 20.0 0.0 0.22 11.4 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42150.1 - 0.0048 17.0 0.0 5.2 7.5 0.0 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42150.1 - 0.0091 16.0 0.6 0.21 11.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDP42150.1 - 0.064 13.6 6.9 0.28 11.5 0.2 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EDP42150.1 - 0.12 12.8 3.1 1.6 9.3 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42150.1 - 0.23 12.2 23.2 1.1 9.9 0.3 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP42150.1 - 0.71 10.6 2.8 19 6.2 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42151.1 - 2.6e-09 37.4 22.5 0.023 15.2 1.2 6.1 4 2 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42151.1 - 6.6e-08 32.1 14.0 1.1 9.5 0.1 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP42151.1 - 1.2e-07 32.0 48.3 0.001 19.7 2.2 10.5 7 4 6 13 13 12 4 Tetratricopeptide repeat TPR_6 PF13174.6 EDP42151.1 - 4e-07 30.3 4.8 0.82 10.4 0.0 6.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP42151.1 - 8.3e-07 28.6 1.1 1.6 8.7 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42151.1 - 5.4e-06 26.2 1.4 6.2 7.3 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP42151.1 - 0.00011 22.4 2.6 0.13 12.7 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDP42151.1 - 0.00039 20.0 0.3 0.011 15.4 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.6 EDP42151.1 - 0.00063 20.3 38.8 0.0092 16.6 4.3 6.9 6 2 1 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDP42151.1 - 0.0077 16.4 25.6 0.03 14.5 1.8 5.6 5 1 1 6 6 5 2 Tetratricopeptide repeat BTAD PF03704.17 EDP42151.1 - 0.0084 16.6 0.2 0.0084 16.6 0.2 4.1 3 1 0 3 3 3 1 Bacterial transcriptional activator domain PI3K_P85_iSH2 PF16454.5 EDP42151.1 - 0.099 12.2 0.6 2.7 7.6 0.2 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_7 PF13176.6 EDP42151.1 - 0.1 12.7 2.4 1.2 9.4 0.1 3.9 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 EDP42151.1 - 0.27 11.6 0.1 0.27 11.6 0.1 5.1 6 1 0 6 6 5 0 Tetratricopeptide repeat DUF3151 PF11349.8 EDP42151.1 - 1 9.4 7.3 0.17 12.0 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3151) TPR_12 PF13424.6 EDP42151.1 - 8.2 6.8 31.9 0.16 12.3 0.8 7.2 6 2 2 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42152.1 - 2.1e-05 24.3 0.5 5.4e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EDP42152.1 - 2.5e-05 23.9 0.2 7.8e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42152.1 - 3e-05 23.8 2.6 5.9e-05 22.9 0.2 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42152.1 - 0.00017 22.2 1.0 0.00024 21.7 0.2 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDP42152.1 - 0.0011 18.6 0.3 0.0027 17.3 0.3 1.7 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.6 EDP42152.1 - 0.0012 18.9 2.6 0.0015 18.7 0.3 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDP42152.1 - 0.0014 19.3 2.2 0.02 15.7 0.2 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP42152.1 - 0.059 13.6 1.8 0.12 12.6 1.3 1.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDP42152.1 - 0.09 13.1 4.6 0.11 12.8 0.4 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EDP42153.1 - 4.2e-68 228.7 0.1 6.1e-68 228.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDP42153.1 - 3.1e-32 110.9 0.0 8.3e-32 109.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EDP42153.1 - 3.4e-21 75.1 0.0 7.7e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDP42153.1 - 5.5e-13 49.1 0.0 1.7e-12 47.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EDP42153.1 - 1.3e-12 47.6 0.0 3.3e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDP42153.1 - 0.00047 20.2 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase NARP1 PF12569.8 EDP42154.1 - 2.2e-133 445.9 12.8 1.6e-119 400.2 12.0 2.7 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EDP42154.1 - 5.9e-10 38.5 19.2 3.7e-05 23.5 0.1 8.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDP42154.1 - 1.4e-09 38.0 17.0 2.3e-05 24.4 0.9 6.5 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDP42154.1 - 4.2e-07 30.2 20.8 2 9.4 3.1 9.8 7 3 3 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42154.1 - 1.1e-06 29.2 12.2 0.00033 21.2 0.8 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42154.1 - 5.1e-05 23.7 21.8 0.0078 16.7 0.7 8.1 8 3 2 10 10 10 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDP42154.1 - 0.0001 22.3 2.1 10 6.3 0.0 4.9 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 EDP42154.1 - 0.0002 21.0 5.9 0.0031 17.3 0.1 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42154.1 - 0.00039 20.4 2.6 7.2 7.1 0.1 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42154.1 - 0.003 17.5 10.4 0.035 14.1 0.1 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat ATP13 PF12921.7 EDP42154.1 - 0.021 14.7 0.0 0.23 11.3 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial ATPase expression TPR_12 PF13424.6 EDP42154.1 - 0.023 15.0 15.9 0.028 14.7 0.0 6.2 5 1 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP42154.1 - 0.032 14.5 9.4 1.7 8.9 0.5 4.9 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.7 EDP42154.1 - 0.042 14.1 0.5 0.28 11.4 0.0 2.6 2 0 0 2 2 2 0 Tetratrico peptide repeat TPR_10 PF13374.6 EDP42154.1 - 0.21 11.5 0.1 0.21 11.5 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Pkinase PF00069.25 EDP42155.1 - 1.7e-65 221.0 0.0 2.5e-65 220.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42155.1 - 9.5e-29 100.5 0.0 1.3e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDP42155.1 - 6e-13 49.3 1.4 4.5e-12 46.5 1.4 2.4 1 1 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 EDP42155.1 - 2.4e-10 40.6 0.0 4.2e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EDP42155.1 - 7e-08 32.1 0.0 8.5e-07 28.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDP42155.1 - 2.7e-05 23.3 0.0 4.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EDP42155.1 - 0.00015 21.5 0.0 0.18 11.4 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDP42155.1 - 0.0057 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP42155.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PP-binding PF00550.25 EDP42156.1 - 4e-15 55.9 0.1 5.8e-15 55.4 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EDP42156.1 - 3.3e-06 27.2 0.7 4.5e-06 26.8 0.7 1.2 1 0 0 1 1 1 1 Acyl-carrier Ribosomal_L12_N PF16320.5 EDP42156.1 - 0.2 11.4 4.4 0.53 10.0 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L17 PF01196.19 EDP42157.1 - 2.1e-10 41.3 0.2 1e-09 39.1 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L17 DUF1751 PF08551.10 EDP42158.1 - 2e-11 44.3 3.4 4.6e-11 43.2 3.4 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DUF2417 PF10329.9 EDP42158.1 - 0.068 12.6 9.5 0.11 11.9 9.5 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF4052 PF13261.6 EDP42158.1 - 0.72 9.6 11.8 0.26 11.1 8.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4052) WD40 PF00400.32 EDP42159.1 - 1.5e-42 142.7 17.0 2.1e-07 31.5 0.0 8.4 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42159.1 - 5.6e-20 71.4 0.1 0.00012 22.3 0.0 5.6 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP42159.1 - 0.003 16.6 0.0 2.7 6.9 0.0 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDP42159.1 - 0.003 17.4 0.0 0.089 12.7 0.0 2.8 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDP42159.1 - 0.04 12.6 0.2 0.32 9.6 0.0 2.4 3 1 0 3 3 3 0 Nucleoporin Nup120/160 Ribosomal_S7 PF00177.21 EDP42160.1 - 2.1e-36 124.8 0.4 2.5e-36 124.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e CtaG_Cox11 PF04442.14 EDP42161.1 - 1.8e-57 193.6 0.1 2.1e-57 193.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DKCLD PF08068.12 EDP42162.1 - 3.2e-31 107.2 0.1 3e-30 104.1 0.2 2.3 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EDP42162.1 - 1.2e-23 83.0 0.8 2.3e-23 82.1 0.8 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EDP42162.1 - 1.6e-22 80.5 6.1 2.6e-21 76.5 0.1 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EDP42162.1 - 3.8e-21 74.8 0.7 7.4e-21 73.9 0.7 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EDP42162.1 - 0.0052 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain CDC45 PF02724.14 EDP42162.1 - 8.1 4.6 31.1 10 4.3 31.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L22e PF01776.17 EDP42163.1 - 6e-44 148.9 0.1 7.4e-44 148.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Spb1_C PF07780.12 EDP42164.1 - 1.1e-75 253.9 20.7 1.1e-75 253.9 20.7 3.5 4 0 0 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.19 EDP42164.1 - 1.7e-53 181.4 0.0 2.9e-53 180.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EDP42164.1 - 3.9e-46 156.9 3.1 3.9e-46 156.9 3.1 5.2 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) DUF148 PF02520.17 EDP42164.1 - 0.097 12.8 5.5 0.07 13.2 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 eIF2A PF08662.11 EDP42165.1 - 9.8e-39 133.2 0.1 9e-35 120.3 0.0 3.9 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EDP42165.1 - 0.00012 21.9 0.0 0.00032 20.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 EDP42165.1 - 0.003 17.8 0.0 49 4.3 0.0 5.6 6 1 1 7 7 7 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDP42165.1 - 0.0095 16.8 2.0 2 9.4 0.1 5.1 6 0 0 6 6 6 1 WD domain, G-beta repeat Lgl_C PF08596.10 EDP42165.1 - 0.09 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal YccJ PF13993.6 EDP42165.1 - 0.17 12.2 2.4 0.37 11.2 0.1 2.8 3 0 0 3 3 3 0 YccJ-like protein PEX11 PF05648.14 EDP42166.1 - 4.2e-64 216.1 2.1 4.7e-64 215.9 2.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DNApol3-delta_C PF09115.10 EDP42166.1 - 0.027 15.0 0.0 0.051 14.1 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal Sel1 PF08238.12 EDP42167.1 - 1e-06 29.2 23.8 0.025 15.2 0.2 7.0 5 2 0 5 5 5 4 Sel1 repeat TPR_11 PF13414.6 EDP42167.1 - 0.053 13.2 3.9 3.7 7.3 0.4 3.4 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 EDP42167.1 - 0.14 12.6 1.3 13 6.4 0.1 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat SR-25 PF10500.9 EDP42167.1 - 0.14 11.7 5.8 0.15 11.6 4.7 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TPR_1 PF00515.28 EDP42167.1 - 0.39 10.6 2.6 16 5.6 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42167.1 - 1.1 9.6 3.9 35 4.9 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Deltaretro_Tax PF05599.11 EDP42168.1 - 0.0011 19.4 0.8 0.003 18.0 0.7 1.9 1 1 0 1 1 1 1 Deltaretrovirus Tax protein Ribosomal_L32p PF01783.23 EDP42168.1 - 0.0015 18.8 2.7 0.0024 18.1 2.7 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family ICL PF00463.21 EDP42169.1 - 2.3e-97 326.7 1.7 2.7e-97 326.5 1.7 1.0 1 0 0 1 1 1 1 Isocitrate lyase family TrbL PF04610.14 EDP42169.1 - 0.056 13.2 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein ICL PF00463.21 EDP42170.1 - 2.6e-152 508.0 0.2 3.1e-152 507.8 0.2 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDP42170.1 - 1.1e-09 38.2 0.1 1.5e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Arg_repressor_C PF02863.18 EDP42170.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Ribo_biogen_C PF04034.13 EDP42171.1 - 1.7e-47 160.3 0.0 2.3e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EDP42171.1 - 7.3e-14 51.3 0.2 1.2e-13 50.6 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SDA1 PF05285.12 EDP42171.1 - 0.0079 15.7 6.9 0.012 15.1 6.9 1.3 1 0 0 1 1 1 1 SDA1 CAF1-p150_C2 PF15539.6 EDP42171.1 - 0.29 10.5 4.6 0.59 9.5 4.6 1.5 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term NOA36 PF06524.12 EDP42171.1 - 3.9 6.7 16.2 6.8 5.9 16.2 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EDP42171.1 - 7.8 4.7 11.2 11 4.1 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Prenyltrans PF00432.21 EDP42173.1 - 1.8e-39 133.1 6.8 1.1e-10 41.1 0.1 4.2 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EDP42173.1 - 0.021 14.0 0.2 0.049 12.7 0.1 1.6 1 1 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain MutS_V PF00488.21 EDP42174.1 - 1.1e-63 214.7 1.1 1.9e-63 213.9 0.1 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EDP42174.1 - 1.7e-33 116.5 4.0 3.2e-33 115.6 4.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EDP42174.1 - 3.5e-09 36.9 0.0 8.3e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EDP42174.1 - 1.7e-08 34.8 0.0 4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EDP42174.1 - 4.7e-05 23.7 0.0 0.00011 22.5 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.6 EDP42174.1 - 0.13 12.0 0.2 0.32 10.8 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DinB_2 PF12867.7 EDP42174.1 - 0.7 10.4 5.9 0.83 10.2 0.7 2.5 2 0 0 2 2 2 0 DinB superfamily RNA_pol_Rpb6 PF01192.22 EDP42175.1 - 4.2e-16 58.6 0.1 5.9e-16 58.1 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 AMP-binding PF00501.28 EDP42176.1 - 2.7e-50 171.2 0.0 4e-50 170.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDP42176.1 - 2.4e-11 43.8 0.9 6.2e-11 42.5 0.9 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 EDP42176.1 - 2.8e-07 30.0 8.2 0.029 14.1 0.1 6.7 6 1 0 6 6 6 2 Bacterial transferase hexapeptide (six repeats) AMP-binding_C PF13193.6 EDP42176.1 - 7.7e-06 26.8 0.2 0.022 15.7 0.1 2.7 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EDP42176.1 - 0.026 13.4 0.0 1 8.1 0.0 2.1 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Hexapep_2 PF14602.6 EDP42176.1 - 1.2 9.0 9.3 6.3 6.6 0.1 5.2 5 1 1 6 6 6 0 Hexapeptide repeat of succinyl-transferase Hepar_II_III PF07940.13 EDP42177.1 - 8.8e-11 41.9 0.1 2.8e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 Heparinase II/III-like protein DUF4962 PF16332.5 EDP42177.1 - 9.6e-05 21.1 5.2 0.00015 20.4 5.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) Pilin_N PF07790.11 EDP42177.1 - 0.14 13.1 0.5 0.69 10.9 0.1 2.3 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal TPPK_C PF12555.8 EDP42177.1 - 0.44 10.6 7.0 0.073 13.1 2.2 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Pkinase PF00069.25 EDP42178.1 - 6e-28 97.9 0.0 5.5e-27 94.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42178.1 - 1.3e-13 50.8 0.0 2.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP42178.1 - 0.034 14.1 0.2 0.064 13.2 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP42178.1 - 0.05 12.9 0.0 0.076 12.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EDP42178.1 - 0.23 10.4 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF3152 PF11350.8 EDP42179.1 - 0.2 11.3 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) Carn_acyltransf PF00755.20 EDP42180.1 - 2.1e-169 564.9 0.0 2.4e-169 564.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Hydrolase_4 PF12146.8 EDP42181.1 - 0.0029 16.9 0.1 2 7.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP42181.1 - 0.16 11.6 0.1 1.4 8.5 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold tRNA-synt_2 PF00152.20 EDP42182.1 - 4e-80 269.2 0.0 5.2e-80 268.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDP42182.1 - 3.4e-05 23.7 0.0 7.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDP42182.1 - 0.05 13.1 0.2 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Tubulin_C PF03953.17 EDP42183.1 - 9.4e-36 122.8 0.0 1.2e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain RecT PF03837.14 EDP42183.1 - 0.026 14.0 0.1 0.043 13.3 0.1 1.3 1 0 0 1 1 1 0 RecT family Tubulin PF00091.25 EDP42184.1 - 4.9e-53 180.3 0.0 5.7e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EDP42184.1 - 0.0011 18.6 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDP42184.1 - 0.0035 16.6 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Cupin_8 PF13621.6 EDP42185.1 - 7.8e-15 55.3 0.0 2.1e-12 47.3 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EDP42185.1 - 2.4e-12 47.3 0.0 4.8e-12 46.3 0.0 1.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 EDP42185.1 - 0.0011 18.9 0.4 0.0025 17.7 0.4 1.7 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.12 EDP42185.1 - 0.0061 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.11 EDP42185.1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Cupin domain F-box PF00646.33 EDP42185.1 - 0.058 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 F-box domain TLD PF07534.16 EDP42186.1 - 1e-22 80.9 0.0 1.2e-19 70.9 0.0 3.3 2 1 0 2 2 2 2 TLD RhoGEF PF00621.20 EDP42187.1 - 1.2e-40 139.7 0.1 1.8e-40 139.1 0.1 1.3 1 0 0 1 1 1 1 RhoGEF domain LRR_8 PF13855.6 EDP42187.1 - 2.4e-05 24.0 1.9 0.16 11.8 0.0 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EDP42187.1 - 0.00034 20.9 6.4 0.0013 19.1 0.1 3.4 2 1 2 4 4 4 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDP42187.1 - 0.053 13.6 0.7 1.7 8.9 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EDP42187.1 - 9.3 7.2 12.4 5.4 8.0 0.3 5.4 5 1 0 5 5 5 0 Leucine Rich Repeat MMS1_N PF10433.9 EDP42188.1 - 1.8e-145 485.3 0.0 2.9e-145 484.6 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EDP42188.1 - 3.4e-81 273.1 0.0 1.3e-80 271.2 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region AdoMet_MTase PF07757.13 EDP42189.1 - 3.8e-33 114.1 0.3 4.1e-32 110.8 0.3 2.2 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Ins_P5_2-kin PF06090.12 EDP42191.1 - 9.9e-23 81.1 0.0 1.1e-22 80.9 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase MAPEG PF01124.18 EDP42192.1 - 1e-16 61.0 1.0 1.3e-16 60.7 1.0 1.3 1 0 0 1 1 1 1 MAPEG family Tma16 PF11176.8 EDP42193.1 - 6.7e-36 123.4 0.2 8e-36 123.1 0.2 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 L31 PF09784.9 EDP42193.1 - 0.076 13.4 0.8 0.13 12.7 0.8 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 ADH_zinc_N PF00107.26 EDP42194.1 - 2.4e-14 53.5 0.3 3.7e-14 52.8 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP42194.1 - 4.5e-07 31.0 0.4 1.1e-06 29.8 0.2 1.8 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.10 EDP42194.1 - 0.021 15.0 0.1 0.047 13.9 0.1 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Tetraspanin PF00335.20 EDP42195.1 - 0.0084 15.8 2.6 0.0084 15.8 2.6 1.8 1 1 1 2 2 2 1 Tetraspanin family MARVEL PF01284.23 EDP42195.1 - 0.89 9.6 8.0 1.3 9.0 7.7 1.5 1 1 0 1 1 1 0 Membrane-associating domain COX14 PF14880.6 EDP42195.1 - 2.6 8.0 5.1 0.81 9.6 1.6 2.0 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Myb_DNA-bind_7 PF15963.5 EDP42196.1 - 1.7e-26 91.9 0.8 4.3e-26 90.6 0.8 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EDP42196.1 - 8.3e-07 29.1 2.4 1.1e-06 28.7 0.9 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP42196.1 - 0.055 13.7 0.8 0.055 13.7 0.8 2.7 3 0 0 3 3 3 0 Myb-like DNA-binding domain Bud13 PF09736.9 EDP42197.1 - 9e-44 149.4 5.9 9e-44 149.4 5.9 2.5 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex NCBP3 PF10309.9 EDP42198.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 zf-Nse PF11789.8 EDP42199.1 - 9.1e-13 47.8 0.0 1.7e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EDP42199.1 - 2.5e-07 30.6 0.0 9.1e-06 25.6 0.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger U-box PF04564.15 EDP42199.1 - 7.6e-05 22.8 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 EDP42199.1 - 0.0013 18.5 0.4 0.0049 16.7 0.1 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EDP42199.1 - 0.0098 15.7 0.1 0.044 13.7 0.0 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein DUF3323 PF11796.8 EDP42199.1 - 0.021 14.7 1.1 0.042 13.7 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) CTP_synth_N PF06418.14 EDP42201.1 - 2.6e-96 322.0 0.3 3.6e-56 190.4 1.5 2.1 1 1 1 2 2 2 2 CTP synthase N-terminus GATase PF00117.28 EDP42201.1 - 1.5e-49 168.3 0.0 2.3e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDP42201.1 - 0.021 14.6 0.1 0.081 12.7 0.0 1.9 2 0 0 2 2 2 0 Peptidase C26 Steroid_dh PF02544.16 EDP42202.1 - 2.1e-15 57.0 1.4 9.8e-14 51.6 1.4 2.5 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF2069 PF09842.9 EDP42202.1 - 0.1 12.8 5.1 0.096 12.9 2.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2069) SF3b10 PF07189.11 EDP42203.1 - 4.1e-31 106.9 0.0 4.7e-31 106.7 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) SNF2_N PF00176.23 EDP42204.1 - 2.7e-63 213.8 0.4 4.8e-63 213.0 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EDP42204.1 - 6.8e-52 175.4 14.8 6.8e-52 175.4 14.8 3.5 4 0 0 4 4 4 1 DNA-binding domain Helicase_C PF00271.31 EDP42204.1 - 1.2e-16 61.1 0.0 2.6e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42204.1 - 3.8e-06 27.0 0.0 1.1e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDP42204.1 - 0.0046 16.2 2.2 0.017 14.3 0.0 2.8 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EDP42204.1 - 0.013 15.2 0.0 0.039 13.7 0.0 1.8 1 0 0 1 1 1 0 DEAD/DEAH box helicase Fe_hyd_lg_C PF02906.14 EDP42204.1 - 0.23 11.1 2.6 0.14 11.8 0.4 1.6 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Pex14_N PF04695.13 EDP42205.1 - 7.7e-23 81.9 3.4 3.6e-22 79.7 0.0 2.5 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1485 PF07364.12 EDP42205.1 - 0.0055 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M81 TEX19 PF15553.6 EDP42205.1 - 0.23 11.4 2.0 0.41 10.6 2.0 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 Adaptin_N PF01602.20 EDP42206.1 - 1.8e-110 370.0 0.0 3e-110 369.3 0.0 1.3 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EDP42206.1 - 8.9e-47 159.0 0.0 2e-46 157.9 0.0 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EDP42206.1 - 3.7e-30 104.4 0.0 1.4e-29 102.5 0.0 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EDP42206.1 - 6.5e-18 64.9 1.0 2.1e-09 37.7 0.0 5.0 3 1 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 EDP42206.1 - 2.6e-08 34.1 1.6 0.15 12.1 0.0 3.6 3 0 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EDP42206.1 - 0.00055 20.4 2.1 3.9 8.4 0.2 5.4 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat Arm PF00514.23 EDP42206.1 - 0.007 16.4 1.4 42 4.4 0.0 4.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EDP42206.1 - 0.032 14.5 12.9 1.4 9.4 0.1 5.8 7 0 0 7 7 7 0 HEAT repeat HEAT_EZ PF13513.6 EDP42206.1 - 1.6 9.3 8.3 4.5 7.9 0.4 4.3 3 1 0 4 4 4 0 HEAT-like repeat bZIP_2 PF07716.15 EDP42207.1 - 6.1e-08 32.6 14.7 6.1e-08 32.6 14.7 2.5 3 1 0 3 3 2 1 Basic region leucine zipper DUF2205 PF10224.9 EDP42207.1 - 0.0054 16.7 0.9 0.019 15.0 0.9 1.9 1 0 0 1 1 1 1 Short coiled-coil protein ATP11 PF06644.11 EDP42207.1 - 0.012 15.4 7.5 0.012 15.4 7.5 3.2 2 1 2 4 4 4 0 ATP11 protein bZIP_Maf PF03131.17 EDP42207.1 - 0.012 16.1 5.9 0.012 16.1 5.9 3.2 3 0 0 3 3 3 0 bZIP Maf transcription factor PRKG1_interact PF15898.5 EDP42207.1 - 0.014 16.3 4.3 0.014 16.3 4.3 3.4 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain bZIP_1 PF00170.21 EDP42207.1 - 0.017 15.2 11.1 0.058 13.5 10.6 2.2 1 1 1 2 2 2 0 bZIP transcription factor Shugoshin_N PF07558.11 EDP42207.1 - 0.092 12.6 1.0 0.18 11.7 1.0 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Phlebovirus_NSM PF07246.11 EDP42207.1 - 0.12 11.7 0.8 0.23 10.8 0.8 1.4 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M TSC22 PF01166.18 EDP42207.1 - 0.21 11.9 0.2 0.21 11.9 0.2 1.8 2 0 0 2 2 1 0 TSC-22/dip/bun family ECM11 PF15463.6 EDP42207.1 - 0.85 10.2 8.8 5.8 7.5 1.2 3.1 2 0 0 2 2 2 0 Extracellular mutant protein 11 YabA PF06156.13 EDP42207.1 - 5.4 7.7 8.4 0.17 12.6 0.8 2.4 2 1 0 2 2 2 0 Initiation control protein YabA mRNA_cap_enzyme PF01331.19 EDP42208.1 - 2.2e-25 89.7 0.0 3.7e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EDP42208.1 - 3.1e-17 63.2 0.6 5.9e-17 62.3 0.6 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EDP42208.1 - 0.00021 21.0 0.2 0.0066 16.1 0.1 2.7 1 1 1 2 2 2 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EDP42208.1 - 0.012 15.9 0.0 0.037 14.3 0.0 1.7 2 0 0 2 2 2 0 RNA ligase mRNA_cap_C PF03919.15 EDP42209.1 - 4.9e-19 69.0 0.0 7.6e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.19 EDP42209.1 - 7.1e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Sugar_tr PF00083.24 EDP42210.1 - 1.2e-100 337.5 22.6 1.6e-99 333.8 22.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP42210.1 - 2e-09 36.9 40.5 1.4e-06 27.5 21.0 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EDP42210.1 - 0.1 12.4 0.6 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF697 PF05128.12 EDP42210.1 - 0.35 10.6 2.2 6.4 6.5 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF697) MFS_1 PF07690.16 EDP42211.1 - 2.1e-12 46.7 50.6 2e-09 36.8 32.8 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily ParA PF10609.9 EDP42213.1 - 7.3e-49 166.4 0.0 2.3e-48 164.8 0.0 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_26 PF13500.6 EDP42213.1 - 0.024 14.5 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ubie_methyltran PF01209.18 EDP42213.1 - 0.15 11.3 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FAD_binding_2 PF00890.24 EDP42214.1 - 2.2e-125 419.0 4.7 2.9e-125 418.7 4.7 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EDP42214.1 - 1.2e-44 151.4 1.3 2.1e-44 150.6 1.3 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 EDP42214.1 - 4.5e-05 22.7 1.7 0.044 12.9 2.6 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EDP42214.1 - 0.00014 21.2 0.3 0.045 13.0 0.1 2.4 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 EDP42214.1 - 0.00038 19.8 0.9 0.0042 16.3 0.2 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDP42214.1 - 0.021 14.1 1.4 0.025 13.8 0.3 1.7 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EDP42214.1 - 0.024 13.7 0.2 0.078 12.0 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 EDP42214.1 - 0.12 11.9 1.8 0.47 10.0 1.8 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EDP42214.1 - 0.5 9.0 4.0 0.85 8.3 1.0 2.5 3 0 0 3 3 3 0 HI0933-like protein DUF1690 PF07956.11 EDP42215.1 - 1.2e-17 64.6 3.9 1.5e-17 64.3 3.9 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) rve_3 PF13683.6 EDP42215.1 - 0.0045 16.7 0.3 0.023 14.5 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain PIN_10 PF18478.1 EDP42215.1 - 0.016 15.4 0.1 0.024 14.8 0.1 1.3 1 0 0 1 1 1 0 PIN like domain ATP-synt_F6 PF05511.11 EDP42215.1 - 0.081 13.3 0.8 7.6 7.0 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 YscO PF07321.12 EDP42215.1 - 0.1 12.6 8.5 0.64 10.0 7.9 2.0 1 1 0 1 1 1 0 Type III secretion protein YscO DUF4407 PF14362.6 EDP42215.1 - 0.13 11.6 2.4 0.15 11.4 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RNAse_A_bac PF18431.1 EDP42215.1 - 0.14 13.2 2.1 1 10.3 0.0 2.4 2 1 0 2 2 2 0 Bacterial CdiA-CT RNAse A domain Protamine_P2 PF00841.19 EDP42215.1 - 0.14 12.7 1.3 0.2 12.1 1.3 1.4 1 0 0 1 1 1 0 Sperm histone P2 Phage_Arf PF17585.2 EDP42215.1 - 0.22 11.5 0.9 0.37 10.8 0.9 1.3 1 0 0 1 1 1 0 Accessory recombination function protein zf-C2HC5 PF06221.13 EDP42216.1 - 6.9e-16 58.0 4.6 1.1e-15 57.3 4.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DZR PF12773.7 EDP42216.1 - 0.49 10.5 2.6 1.1 9.3 2.6 1.6 1 0 0 1 1 1 0 Double zinc ribbon Cupin_8 PF13621.6 EDP42217.1 - 4.3e-09 36.5 0.1 3.4e-08 33.5 0.1 2.0 1 1 0 1 1 1 1 Cupin-like domain JHD PF17811.1 EDP42217.1 - 1.3e-06 28.9 0.9 1.4e-05 25.6 0.6 2.5 1 1 1 2 2 2 1 Jumonji helical domain JmjC PF02373.22 EDP42217.1 - 3.5e-06 27.4 0.4 0.00018 21.9 0.0 2.8 2 1 0 2 2 2 1 JmjC domain, hydroxylase efThoc1 PF11957.8 EDP42218.1 - 2.2e-60 204.8 0.1 5.2e-60 203.5 0.1 1.6 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor DUF1981 PF09324.10 EDP42218.1 - 0.095 12.6 0.6 0.23 11.3 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) RRM_1 PF00076.22 EDP42219.1 - 7.2e-13 48.2 0.0 1.8e-12 46.9 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ubiquitin PF00240.23 EDP42220.1 - 6.6e-35 118.7 0.9 4e-34 116.2 0.5 2.1 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 EDP42220.1 - 1.8e-25 88.8 0.7 4.9e-25 87.4 0.7 1.8 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EDP42220.1 - 4.5e-16 58.4 0.5 8.1e-16 57.6 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDP42220.1 - 1.1e-05 25.7 0.5 8e-05 23.0 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDP42220.1 - 0.00047 20.2 0.6 0.0011 19.0 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EDP42220.1 - 0.0039 17.5 1.0 0.01 16.2 0.1 1.9 1 1 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EDP42220.1 - 0.0069 16.3 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EDP42220.1 - 0.0076 16.8 1.0 0.011 16.3 1.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDP42220.1 - 0.037 14.1 3.0 3.5 7.8 0.2 2.6 3 0 0 3 3 3 0 Ubiquitin-like domain DUF4925 PF16272.5 EDP42220.1 - 0.095 12.2 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4925) Plexin_cytopl PF08337.12 EDP42220.1 - 0.33 9.6 3.5 12 4.5 0.5 2.4 2 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain Pkinase PF00069.25 EDP42221.1 - 5e-51 173.6 0.0 6.7e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42221.1 - 5.7e-20 71.7 0.0 9.9e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1713 PF08213.11 EDP42222.1 - 1.9e-12 46.9 23.8 1.9e-12 46.9 23.8 2.2 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) PepSY_2 PF13670.6 EDP42222.1 - 0.13 12.3 0.2 0.13 12.3 0.2 1.9 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Ribosomal_L2_C PF03947.18 EDP42223.1 - 1.1e-51 174.3 0.2 1.6e-51 173.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDP42224.1 - 5.2e-11 42.4 3.0 9.1e-11 41.6 0.2 2.2 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Skp1_POZ PF03931.15 EDP42225.1 - 6.3e-26 90.3 0.1 1.1e-25 89.6 0.1 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 EDP42225.1 - 0.0073 16.5 0.0 0.12 12.6 0.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain Unstab_antitox PF09720.10 EDP42225.1 - 0.11 12.6 0.2 8.8 6.5 0.1 2.1 2 0 0 2 2 2 0 Putative addiction module component DUF3535 PF12054.8 EDP42226.1 - 1e-83 282.0 1.9 3.4e-83 280.3 1.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EDP42226.1 - 8.7e-63 212.1 0.0 2.3e-62 210.7 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP42226.1 - 1.4e-16 60.8 0.0 3.3e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EDP42226.1 - 2.8e-05 24.0 6.8 0.38 11.1 0.0 7.1 7 0 0 7 7 7 1 HEAT repeat Vac14_Fab1_bd PF12755.7 EDP42226.1 - 3.9e-05 24.2 0.2 0.25 12.0 0.1 3.0 2 1 0 2 2 2 2 Vacuolar 14 Fab1-binding region Trypan_PARP PF05887.11 EDP42226.1 - 0.0018 18.3 2.3 0.0018 18.3 2.3 1.6 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) HEAT_EZ PF13513.6 EDP42226.1 - 0.094 13.2 18.1 0.11 13.0 0.1 6.9 7 0 0 7 7 7 0 HEAT-like repeat TonB_N PF16031.5 EDP42226.1 - 0.7 10.4 11.4 1.5 9.3 11.4 1.5 1 0 0 1 1 1 0 TonB polyproline region SPESP1 PF15754.5 EDP42226.1 - 1.1 8.3 5.1 2.2 7.4 5.1 1.4 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Cnd1 PF12717.7 EDP42226.1 - 1.6 8.8 6.6 0.63 10.1 0.5 3.3 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 CIA30 PF08547.12 EDP42227.1 - 1.8e-22 80.0 0.0 1.9e-10 41.0 0.0 2.2 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) SGBP_B_XBD PF18329.1 EDP42227.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain Tim44 PF04280.15 EDP42228.1 - 8.3e-32 110.3 0.0 8.2e-31 107.1 0.0 2.3 2 0 0 2 2 2 1 Tim44-like domain Seryl_tRNA_N PF02403.22 EDP42228.1 - 0.019 15.2 1.6 0.041 14.1 1.4 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Mis14 PF08641.12 EDP42228.1 - 0.05 13.9 2.2 0.094 13.0 0.8 2.2 1 1 1 2 2 2 0 Kinetochore protein Mis14 like RGS12_us2 PF16611.5 EDP42228.1 - 0.053 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Unstructured region between RBD and GoLoco Pex19 PF04614.12 EDP42228.1 - 0.25 11.1 2.5 0.44 10.3 2.5 1.4 1 0 0 1 1 1 0 Pex19 protein family TMF_TATA_bd PF12325.8 EDP42228.1 - 1.6 8.9 6.5 41 4.4 6.5 2.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Smr PF01713.21 EDP42229.1 - 1.2e-06 28.8 0.0 4.6e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Smr domain zf-CCCH PF00642.24 EDP42229.1 - 5.5e-05 23.0 8.6 0.00048 20.0 1.3 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP42229.1 - 0.0005 20.0 7.1 0.38 10.9 1.9 3.0 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 EDP42229.1 - 0.0013 19.1 10.2 0.055 14.0 2.5 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EDP42229.1 - 0.049 13.4 16.8 0.067 13.0 4.9 3.4 2 2 0 2 2 2 0 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDP42229.1 - 0.058 13.6 5.8 0.38 11.0 5.8 2.1 1 1 0 1 1 1 0 Zinc-finger containing family zf-C3H1 PF10650.9 EDP42229.1 - 2 8.3 9.9 4.4 7.1 1.1 2.7 3 0 0 3 3 3 0 Putative zinc-finger domain Torus PF16131.5 EDP42229.1 - 2.3 9.0 4.0 11 6.8 0.2 2.4 1 1 1 2 2 2 0 Torus domain Paf1 PF03985.13 EDP42230.1 - 1.5e-40 139.5 9.6 8.8e-31 107.3 0.1 2.7 2 1 1 3 3 3 2 Paf1 UCH_1 PF13423.6 EDP42231.1 - 4.2e-71 240.1 0.0 5.7e-71 239.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EDP42231.1 - 1.8e-16 61.2 0.0 4.3e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EDP42231.1 - 0.0028 17.2 0.0 0.071 12.6 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 EDP42231.1 - 0.0032 18.3 0.9 0.2 12.6 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42231.1 - 0.013 15.8 0.0 4.3 7.7 0.0 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDP42231.1 - 0.082 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Mitoc_mL59 PF18126.1 EDP42232.1 - 1.7e-25 89.8 10.6 3.1e-25 89.0 10.6 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Q_salvage PF10343.9 EDP42233.1 - 1.1e-06 28.5 0.0 8.9e-06 25.5 0.0 2.5 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family VHS PF00790.19 EDP42234.1 - 7e-36 123.2 2.2 9.5e-36 122.7 0.9 1.7 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 EDP42234.1 - 1.4e-15 56.6 0.0 2.8e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP42234.1 - 1.4e-14 53.6 0.5 3.2e-14 52.5 0.5 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP42234.1 - 4.4e-11 42.3 0.1 8.1e-11 41.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EDP42234.1 - 7.4e-08 32.6 2.1 6.7e-07 29.5 0.4 3.1 2 1 1 3 3 3 1 GAT domain UIM PF02809.20 EDP42234.1 - 0.00073 19.3 1.3 0.0029 17.4 1.3 2.1 1 0 0 1 1 1 1 Ubiquitin interaction motif Hrs_helical PF12210.8 EDP42234.1 - 0.025 15.1 0.8 0.025 15.1 0.8 2.5 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate HEAT_2 PF13646.6 EDP42234.1 - 0.077 13.4 0.9 0.38 11.2 0.3 2.5 2 0 0 2 2 2 0 HEAT repeats TPR_1 PF00515.28 EDP42235.1 - 1.3e-06 28.0 1.1 0.0031 17.3 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 EDP42235.1 - 4e-05 23.4 0.0 0.00012 21.9 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_2 PF07719.17 EDP42235.1 - 0.00028 20.8 8.7 0.012 15.7 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat DnaJ PF00226.31 EDP42235.1 - 0.00029 20.9 0.1 0.00065 19.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_12 PF13424.6 EDP42235.1 - 0.1 12.9 5.0 0.17 12.2 0.3 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42235.1 - 0.26 11.9 0.0 0.26 11.9 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EDP42236.1 - 1.1e-40 139.2 0.8 1.5e-40 138.8 0.8 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EDP42236.1 - 1e-13 51.7 0.6 6.2e-13 49.2 0.0 2.5 2 1 1 3 3 3 1 PCI domain RPN6_N PF18055.1 EDP42237.1 - 1.7e-22 80.0 7.2 1.8e-22 79.9 0.7 2.7 3 0 0 3 3 3 2 26S proteasome regulatory subunit RPN6 N-terminal domain RPN7 PF10602.9 EDP42237.1 - 0.0076 16.0 0.6 0.016 14.9 0.2 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 Aha1_N PF09229.11 EDP42238.1 - 3.2e-32 111.6 0.0 4.6e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EDP42238.1 - 4.3e-18 65.7 0.0 1.2e-17 64.3 0.0 1.7 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 EDP42238.1 - 0.0038 17.5 0.0 0.0089 16.3 0.0 1.6 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport YqfQ PF14181.6 EDP42238.1 - 0.17 12.1 4.1 0.29 11.3 4.1 1.3 1 0 0 1 1 1 0 YqfQ-like protein RTT107_BRCT_6 PF16771.5 EDP42240.1 - 0.045 13.9 0.3 8.8 6.5 0.0 2.4 1 1 1 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Cdh1_DBD_1 PF18196.1 EDP42240.1 - 0.057 13.7 0.8 9.6 6.5 0.3 2.5 1 1 1 2 2 2 0 Chromodomain helicase DNA-binding domain 1 DUF1967 PF09269.11 EDP42240.1 - 0.088 12.8 0.6 38 4.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) DUF883 PF05957.13 EDP42240.1 - 0.29 11.8 5.6 18 6.0 1.0 3.7 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF5618 PF18498.1 EDP42240.1 - 1.5 9.1 6.6 1.3 9.2 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF5618) YtxH PF12732.7 EDP42240.1 - 4.9 7.8 11.0 1.2e+03 0.1 11.0 2.7 1 1 0 1 1 1 0 YtxH-like protein COX7C PF02935.16 EDP42241.1 - 0.035 14.4 0.6 0.078 13.2 0.6 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc Macoilin PF09726.9 EDP42241.1 - 6.9 5.1 7.5 7.6 4.9 7.5 1.0 1 0 0 1 1 1 0 Macoilin family DnaJ PF00226.31 EDP42242.1 - 2.4e-17 62.8 2.3 2.5e-17 62.7 0.2 2.2 3 0 0 3 3 3 1 DnaJ domain TraW_N PF12477.8 EDP42242.1 - 0.12 12.4 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal RcsF PF16358.5 EDP42242.1 - 0.14 12.3 1.4 0.27 11.3 0.2 2.1 1 1 1 2 2 2 0 RcsF lipoprotein FAM76 PF16046.5 EDP42242.1 - 1.6 8.0 4.5 2.6 7.3 4.5 1.2 1 0 0 1 1 1 0 FAM76 protein Cyclin_N PF00134.23 EDP42243.1 - 0.00069 19.4 0.2 0.0014 18.3 0.2 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain MatE PF01554.18 EDP42244.1 - 1e-47 161.8 27.1 1.6e-24 86.4 11.2 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EDP42244.1 - 3e-07 30.6 7.2 3e-07 30.6 7.2 3.9 2 2 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Mito_carr PF00153.27 EDP42245.1 - 8.6e-26 89.7 0.8 8.3e-17 60.9 0.2 2.6 2 0 0 2 2 2 2 Mitochondrial carrier protein DEAD PF00270.29 EDP42246.1 - 2.2e-46 157.9 0.0 3.8e-46 157.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42246.1 - 8.2e-24 84.1 0.0 2.2e-23 82.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDP42246.1 - 2.7e-19 69.2 0.2 6.4e-19 67.9 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDP42246.1 - 3.9e-07 30.2 0.0 1e-06 28.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EDP42246.1 - 0.081 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain 30K_MP_C_Ter PF11330.8 EDP42246.1 - 0.13 11.6 0.2 0.23 10.8 0.2 1.3 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins BUD22 PF09073.10 EDP42246.1 - 1 8.6 29.5 0.036 13.4 7.5 2.3 2 0 0 2 2 2 0 BUD22 Ank_3 PF13606.6 EDP42247.1 - 0.61 10.8 2.6 1.5e+02 3.5 0.0 4.0 4 0 0 4 4 4 0 Ankyrin repeat TPT PF03151.16 EDP42248.1 - 8.7e-53 179.5 16.6 1.5e-52 178.8 16.6 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EDP42248.1 - 7.3e-16 58.6 22.3 1.6e-10 41.3 9.8 2.6 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EDP42248.1 - 3.4e-11 42.9 16.5 5.3e-11 42.3 16.2 1.3 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EDP42248.1 - 2e-07 30.5 8.6 6e-05 22.4 1.1 2.1 1 1 0 2 2 2 2 Nucleotide-sugar transporter TMEM234 PF10639.9 EDP42248.1 - 0.28 11.2 8.4 4.5 7.3 1.0 2.6 2 0 0 2 2 2 0 Putative transmembrane family 234 Multi_Drug_Res PF00893.19 EDP42248.1 - 0.63 10.7 8.3 0.13 13.0 1.9 2.7 2 1 0 2 2 2 0 Small Multidrug Resistance protein BAG PF02179.16 EDP42249.1 - 1.7e-18 66.8 0.2 2.8e-18 66.1 0.2 1.3 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EDP42249.1 - 1.2e-07 31.4 0.4 4.7e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 EDP42249.1 - 0.023 15.2 0.1 0.71 10.4 0.0 2.9 3 1 0 3 3 3 0 Ubiquitin-like domain zf-TFIIIC PF12660.7 EDP42250.1 - 1.4e-08 34.6 5.1 4.6e-08 32.9 5.1 1.9 1 1 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex DnaJ-X PF14308.6 EDP42251.1 - 9.2e-66 221.3 0.4 9.2e-66 221.3 0.4 2.5 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDP42251.1 - 3.3e-18 65.6 2.2 3.4e-18 65.5 0.1 2.2 3 0 0 3 3 3 1 DnaJ domain Raftlin PF15250.6 EDP42251.1 - 0.19 10.5 5.2 0.32 9.7 5.2 1.3 1 0 0 1 1 1 0 Raftlin CBP_BcsG PF11658.8 EDP42251.1 - 0.69 8.2 3.1 1 7.7 3.1 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF2120 PF09893.9 EDP42251.1 - 0.91 9.6 7.4 0.14 12.3 1.3 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) IMUP PF15761.5 EDP42251.1 - 7.3 7.3 14.7 0.22 12.2 8.1 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein Ribosomal_S4e PF00900.20 EDP42252.1 - 8.2e-33 112.2 0.1 1.6e-32 111.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EDP42252.1 - 5.9e-23 80.3 0.0 1.3e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EDP42252.1 - 4.3e-19 68.3 6.9 8.6e-19 67.4 6.2 1.9 2 0 0 2 2 2 1 RS4NT (NUC023) domain S4 PF01479.25 EDP42252.1 - 0.00043 19.9 0.2 0.0034 17.1 0.0 2.4 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 EDP42252.1 - 0.14 12.2 4.6 0.095 12.7 1.7 2.3 2 0 0 2 2 2 0 KOW motif CwfJ_C_2 PF04676.14 EDP42253.1 - 1.7e-35 121.9 0.1 3.1e-35 121.0 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 EDP42253.1 - 1.2e-05 25.1 0.1 1.8e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Rnk_N PF14760.6 EDP42254.1 - 0.44 11.1 3.1 1.2 9.7 3.1 1.7 1 0 0 1 1 1 0 Rnk N-terminus Zip PF02535.22 EDP42255.1 - 2.9e-59 201.0 6.8 3.7e-59 200.6 6.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter ArgJ PF01960.18 EDP42256.1 - 1.2e-124 415.8 0.0 1.5e-124 415.5 0.0 1.0 1 0 0 1 1 1 1 ArgJ family Peptidase_S58 PF03576.14 EDP42256.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S58 Thioredoxin_8 PF13905.6 EDP42257.1 - 5.3e-07 29.9 0.0 1.2e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like LIP PF03583.14 EDP42258.1 - 4e-45 154.4 0.0 5.4e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase SelP_N PF04592.14 EDP42258.1 - 3 7.2 14.2 4.6 6.6 14.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Cyclin PF08613.11 EDP42260.1 - 3.1e-39 134.9 1.1 8.5e-23 81.5 0.4 2.4 2 0 0 2 2 2 2 Cyclin Thiolase_N PF00108.23 EDP42261.1 - 8.6e-80 267.8 3.5 9.1e-80 267.7 2.2 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDP42261.1 - 3.5e-42 142.9 1.0 3.5e-42 142.9 1.0 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDP42261.1 - 0.018 14.6 0.3 0.018 14.6 0.3 3.0 4 0 0 4 4 4 0 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EDP42261.1 - 0.021 15.0 0.1 0.087 13.0 0.1 2.1 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal CENP-T_C PF15511.6 EDP42262.1 - 4.7e-08 33.1 0.1 5.7e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EDP42262.1 - 0.00029 20.9 0.1 0.00044 20.4 0.1 1.5 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EDP42262.1 - 0.00046 20.4 0.1 0.00094 19.4 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EDP42262.1 - 0.00057 20.2 0.0 0.00074 19.8 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 EDP42262.1 - 0.00065 20.1 0.1 0.00073 19.9 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDP42262.1 - 0.061 13.4 0.0 0.069 13.2 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EDP42263.1 - 1.6e-50 170.9 2.9 1.7e-50 170.7 2.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDP42263.1 - 6.7e-05 23.2 0.0 0.0001 22.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDP42263.1 - 0.00017 21.6 0.8 0.00023 21.3 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDP42263.1 - 0.00034 21.2 1.5 0.00041 20.9 1.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDP42263.1 - 0.0014 18.8 0.1 0.0027 17.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDP42263.1 - 0.036 14.1 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EDP42263.1 - 0.1 12.6 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated Hydrolase_4 PF12146.8 EDP42264.1 - 1e-38 133.0 0.0 1.6e-38 132.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDP42264.1 - 3.1e-11 44.3 1.2 3.9e-11 44.0 1.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDP42264.1 - 1.3e-09 38.1 0.1 3.1e-08 33.6 0.1 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EDP42264.1 - 9.2e-06 25.7 0.0 0.00025 21.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDP42264.1 - 0.0019 17.7 0.0 1.8 8.0 0.0 2.9 2 1 1 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EDP42264.1 - 0.053 13.3 0.0 0.7 9.6 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase LIDHydrolase PF10230.9 EDP42264.1 - 0.093 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Glyco_transf_8 PF01501.20 EDP42265.1 - 1.4e-12 47.7 0.1 1.8e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EDP42265.1 - 0.028 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative DUF2420 PF10336.9 EDP42266.1 - 2.5e-12 46.8 0.1 1.6e-11 44.2 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF2420) UCH PF00443.29 EDP42267.1 - 2.7e-72 243.3 0.0 3.6e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP42267.1 - 2.1e-13 50.5 0.0 1.4e-05 24.9 0.0 3.0 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EDP42267.1 - 9.1e-11 42.2 0.0 1.7e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 DUSP domain YukD PF08817.10 EDP42267.1 - 0.15 12.7 0.1 0.54 11.0 0.1 1.9 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Glutaredoxin PF00462.24 EDP42268.1 - 1.3e-19 70.2 0.0 4.9e-18 65.1 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EDP42268.1 - 6.7e-14 51.7 0.0 1.3e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDP42268.1 - 0.00019 21.8 0.0 0.00088 19.7 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EDP42268.1 - 0.00028 21.1 0.1 0.11 12.8 0.0 2.5 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_3 PF13192.6 EDP42268.1 - 0.034 14.2 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin domain GST_N_3 PF13417.6 EDP42268.1 - 0.055 13.9 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Phosducin PF02114.16 EDP42268.1 - 0.057 12.4 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosducin OST3_OST6 PF04756.13 EDP42268.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HyaE PF07449.11 EDP42268.1 - 0.13 12.3 0.0 0.5 10.4 0.0 1.9 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE Nuf2 PF03800.14 EDP42269.1 - 4e-27 95.0 0.4 9e-27 93.9 0.4 1.6 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 EDP42269.1 - 7.5e-05 22.8 18.5 0.00014 21.9 0.2 3.4 1 1 2 3 3 3 1 Designed helical repeat protein 10 domain COPIIcoated_ERV PF07970.12 EDP42269.1 - 0.026 14.4 0.4 0.036 13.9 0.4 1.4 1 1 0 1 1 1 0 Endoplasmic reticulum vesicle transporter DUF2935 PF11155.8 EDP42269.1 - 0.035 14.4 0.1 0.11 12.9 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) SPATA24 PF15175.6 EDP42269.1 - 0.045 13.7 8.4 0.052 13.5 7.0 1.7 1 1 0 1 1 1 0 Spermatogenesis-associated protein 24 YojJ PF10372.9 EDP42269.1 - 0.056 13.5 5.5 2.5 8.2 0.1 3.7 2 1 2 4 4 4 0 Bacterial membrane-spanning protein N-terminus SOAR PF16533.5 EDP42269.1 - 0.2 11.6 6.0 1.4 9.0 0.6 2.9 2 1 1 3 3 3 0 STIM1 Orai1-activating region Yuri_gagarin PF15934.5 EDP42269.1 - 0.21 11.4 12.3 0.3 10.9 11.7 1.6 1 1 0 1 1 1 0 Yuri gagarin HAUS-augmin3 PF14932.6 EDP42269.1 - 1.1 8.8 12.2 2.7 7.5 12.1 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Nnf1 PF03980.14 EDP42269.1 - 1.4 9.4 11.1 1.2 9.5 9.0 2.1 1 1 0 1 1 1 0 Nnf1 bZIP_1 PF00170.21 EDP42269.1 - 1.4 9.0 8.3 9.3 6.4 1.3 3.4 3 1 0 3 3 3 0 bZIP transcription factor DMPK_coil PF08826.10 EDP42269.1 - 2 8.6 14.7 3.7 7.7 0.2 3.6 1 1 2 4 4 4 0 DMPK coiled coil domain like ATG16 PF08614.11 EDP42269.1 - 2.6 8.2 19.2 16 5.7 6.7 2.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) BRE1 PF08647.11 EDP42269.1 - 6.9 6.8 13.6 4.7 7.4 5.5 3.1 1 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase GHMP_kinases_N PF00288.26 EDP42270.1 - 1.5e-10 41.1 0.1 3.8e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDP42270.1 - 0.00093 19.5 0.0 0.0026 18.1 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal SAC3_GANP PF03399.16 EDP42271.1 - 8.9e-22 77.8 11.9 1.4e-20 73.9 7.0 2.7 2 1 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EDP42271.1 - 0.034 14.1 0.8 0.064 13.2 0.1 1.8 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family DUF982 PF06169.12 EDP42271.1 - 0.035 14.1 0.0 0.095 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF982) AAA_33 PF13671.6 EDP42272.1 - 1.9e-10 41.1 3.4 6e-07 29.7 0.3 2.1 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 EDP42272.1 - 2.5e-05 24.8 0.2 0.00073 20.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EDP42272.1 - 0.0014 19.0 0.7 0.012 16.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EDP42272.1 - 0.1 12.0 0.8 2.2 7.7 0.0 2.0 1 1 1 2 2 2 0 Chromatin associated protein KTI12 SKI PF01202.22 EDP42272.1 - 0.16 12.1 0.5 1.7 8.7 0.0 2.4 2 1 0 2 2 2 0 Shikimate kinase dNK PF01712.19 EDP42272.1 - 0.16 11.8 0.0 2.7 7.8 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase cobW PF02492.19 EDP42272.1 - 0.16 11.5 0.3 0.31 10.6 0.2 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain WD40 PF00400.32 EDP42273.1 - 0.00017 22.3 4.2 36 5.5 0.0 6.5 6 1 0 6 6 6 3 WD domain, G-beta repeat IGPD PF00475.18 EDP42274.1 - 4.7e-61 205.3 2.4 6.4e-61 204.9 2.4 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase SAP PF02037.27 EDP42275.1 - 1.2e-11 44.0 0.9 1.8e-11 43.5 0.9 1.3 1 0 0 1 1 1 1 SAP domain FANC_SAP PF18081.1 EDP42275.1 - 0.025 14.7 0.6 0.053 13.7 0.6 1.5 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain Actin PF00022.19 EDP42276.1 - 4.1e-20 71.8 0.0 2e-09 36.6 0.0 3.0 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 EDP42276.1 - 5.7e-10 38.9 0.0 6.8e-06 25.5 0.0 2.1 2 0 0 2 2 2 2 Putative actin-like family SOG2 PF10428.9 EDP42276.1 - 0.0029 16.9 8.8 0.0054 16.0 8.8 1.4 1 0 0 1 1 1 1 RAM signalling pathway protein MreB_Mbl PF06723.13 EDP42276.1 - 0.028 13.3 0.0 5.1 5.8 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein MTHFR PF02219.17 EDP42277.1 - 8.5e-74 248.4 0.0 4.7e-62 209.9 0.0 2.2 1 1 1 2 2 2 2 Methylenetetrahydrofolate reductase SMC_Nse1 PF07574.13 EDP42278.1 - 2.4e-24 86.3 0.6 9.7e-24 84.3 0.6 1.8 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EDP42278.1 - 1.9e-07 31.3 9.9 3.7e-07 30.3 9.9 1.5 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 EDP42278.1 - 0.03 14.6 5.0 0.057 13.8 5.0 1.5 1 0 0 1 1 1 0 Ring finger domain MarR_2 PF12802.7 EDP42278.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 MarR family Aminotran_1_2 PF00155.21 EDP42279.1 - 5.1e-74 249.6 0.0 5.8e-74 249.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II ubiquitin PF00240.23 EDP42280.1 - 1.8e-34 117.3 0.5 3e-34 116.6 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EDP42280.1 - 4.4e-16 58.5 0.6 7.1e-16 57.8 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.16 EDP42280.1 - 2e-09 37.5 6.8 3.3e-09 36.8 6.8 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.6 EDP42280.1 - 2.9e-05 24.4 0.1 0.00013 22.4 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EDP42280.1 - 0.0055 17.0 0.2 0.011 16.0 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDP42280.1 - 0.006 16.7 0.0 0.017 15.2 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EDP42280.1 - 0.0064 16.4 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDP42280.1 - 0.016 15.2 1.1 5.4 7.1 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EDP42280.1 - 0.022 15.3 0.0 0.03 14.9 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain PX PF00787.24 EDP42281.1 - 6.9e-20 71.1 0.2 1.4e-19 70.2 0.2 1.5 1 0 0 1 1 1 1 PX domain BAR PF03114.18 EDP42281.1 - 0.0011 18.7 7.6 0.074 12.7 2.6 2.4 2 0 0 2 2 2 2 BAR domain Vps5 PF09325.10 EDP42281.1 - 0.025 14.1 0.3 0.025 14.1 0.3 2.2 2 0 0 2 2 2 0 Vps5 C terminal like Trimer_CC PF08954.11 EDP42281.1 - 0.05 13.2 0.8 0.13 11.8 0.8 1.7 1 0 0 1 1 1 0 Trimerisation motif Rep_fac_C PF08542.11 EDP42282.1 - 5e-23 81.3 0.3 1.7e-22 79.6 0.1 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 EDP42282.1 - 6.4e-18 65.4 0.0 1.4e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDP42282.1 - 5.9e-13 48.9 0.0 1.2e-09 38.2 0.0 2.5 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 EDP42282.1 - 6.5e-09 36.0 0.0 1.2e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EDP42282.1 - 1.8e-06 28.4 2.8 0.00012 22.5 2.8 2.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EDP42282.1 - 2e-06 27.7 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EDP42282.1 - 3.3e-06 27.3 0.0 9.2e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_30 PF13604.6 EDP42282.1 - 3.9e-06 26.7 0.1 1.7e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDP42282.1 - 4.4e-06 26.7 0.2 0.00049 20.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EDP42282.1 - 5.1e-06 26.3 0.3 4.3e-05 23.3 0.1 2.5 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDP42282.1 - 1.2e-05 25.3 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 EDP42282.1 - 6.3e-05 23.1 0.0 0.0032 17.5 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDP42282.1 - 0.00016 22.0 0.1 0.03 14.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EDP42282.1 - 0.00026 20.2 0.0 0.00041 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EDP42282.1 - 0.00034 20.7 0.0 0.00074 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EDP42282.1 - 0.00095 19.0 0.1 0.002 17.9 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.6 EDP42282.1 - 0.0015 18.8 0.2 0.023 15.0 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDP42282.1 - 0.0017 17.9 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_3 PF07726.11 EDP42282.1 - 0.0017 18.2 0.0 0.0055 16.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EDP42282.1 - 0.0024 17.7 0.3 0.012 15.4 0.5 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_23 PF13476.6 EDP42282.1 - 0.0025 18.3 0.0 0.0044 17.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EDP42282.1 - 0.0044 17.3 0.3 0.024 14.9 0.2 2.4 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EDP42282.1 - 0.0061 16.0 0.0 0.041 13.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EDP42282.1 - 0.013 15.1 0.0 0.03 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDP42282.1 - 0.023 15.1 0.0 0.047 14.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EDP42282.1 - 0.025 15.1 0.0 0.057 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDP42282.1 - 0.033 13.9 0.1 0.15 11.8 0.1 2.0 1 1 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 EDP42282.1 - 0.062 12.7 0.1 1.2 8.5 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein DUF2075 PF09848.9 EDP42282.1 - 0.068 12.4 0.7 1.5 8.0 0.7 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EDP42282.1 - 0.075 12.5 0.2 2.6 7.5 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Thioredoxin_6 PF13848.6 EDP42282.1 - 0.084 12.8 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain DUF1525 PF07511.11 EDP42282.1 - 0.36 11.0 1.8 5.6 7.1 0.0 2.7 3 1 0 3 3 2 0 Protein of unknown function (DUF1525) CLASP_N PF12348.8 EDP42283.1 - 3.1e-68 229.7 0.3 1.2e-64 218.0 0.2 2.6 3 0 0 3 3 2 2 CLASP N terminal HEAT PF02985.22 EDP42283.1 - 6.3e-08 32.2 5.5 0.049 13.9 0.0 6.5 6 0 0 6 6 5 2 HEAT repeat HEAT_2 PF13646.6 EDP42283.1 - 1.7e-06 28.3 5.2 0.024 15.0 0.1 4.4 4 0 0 4 4 3 2 HEAT repeats HEAT_EZ PF13513.6 EDP42283.1 - 2.1e-06 28.1 7.1 0.47 11.0 0.2 5.8 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 EDP42283.1 - 0.0011 19.1 0.1 5.3 7.1 0.0 3.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 EDP42283.1 - 0.0036 17.6 0.2 1e+02 3.4 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Plasmodium_Vir PF05795.11 EDP42283.1 - 0.022 14.2 2.4 0.038 13.4 2.4 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Spt20 PF12090.8 EDP42283.1 - 0.061 12.9 24.2 0.13 11.9 24.2 1.4 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 EDP42283.1 - 0.064 12.7 5.5 0.11 12.0 5.5 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pox_Ag35 PF03286.14 EDP42283.1 - 0.22 11.3 8.1 0.64 9.8 8.1 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 EDP42283.1 - 0.26 10.0 8.4 0.44 9.3 8.4 1.4 1 0 0 1 1 1 0 Presenilin RXT2_N PF08595.11 EDP42283.1 - 0.31 11.0 5.9 0.68 10.0 5.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal FHIPEP PF00771.20 EDP42283.1 - 0.36 9.3 4.9 0.64 8.4 4.9 1.3 1 0 0 1 1 1 0 FHIPEP family ALMT PF11744.8 EDP42283.1 - 0.39 9.5 3.0 0.69 8.7 3.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Tim54 PF11711.8 EDP42283.1 - 0.42 9.4 9.0 0.88 8.3 9.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 EDP42283.1 - 0.46 10.2 4.1 0.83 9.4 4.1 1.4 1 0 0 1 1 1 0 Connexin TFB6 PF17110.5 EDP42283.1 - 0.8 9.4 5.0 1.8 8.3 5.0 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Spore_coat_CotO PF14153.6 EDP42283.1 - 1.2 9.0 16.9 2.3 8.1 16.9 1.4 1 0 0 1 1 1 0 Spore coat protein CotO PBP_sp32 PF07222.12 EDP42283.1 - 1.4 8.3 11.4 3.4 7.1 9.7 2.4 2 0 0 2 2 2 0 Proacrosin binding protein sp32 FAM60A PF15396.6 EDP42283.1 - 1.6 8.7 4.1 3.6 7.5 4.1 1.6 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.16 EDP42283.1 - 2.6 7.5 7.8 4.3 6.8 7.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Androgen_recep PF02166.16 EDP42283.1 - 3.2 6.5 22.8 7.4 5.3 22.8 1.5 1 0 0 1 1 1 0 Androgen receptor DUF913 PF06025.12 EDP42283.1 - 3.5 6.5 9.1 9.9 5.0 9.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 EDP42283.1 - 3.7 6.4 12.0 5.7 5.8 12.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 EDP42283.1 - 4.3 7.1 12.2 18 5.0 9.1 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF4834 PF16118.5 EDP42283.1 - 6.8 7.7 14.0 23 6.0 14.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DnaJ-X PF14308.6 EDP42283.1 - 7.8 5.9 9.9 1.1e+02 2.1 8.9 2.3 2 0 0 2 2 2 0 X-domain of DnaJ-containing Peptidase_S64 PF08192.11 EDP42283.1 - 8.4 4.8 9.4 13 4.1 9.4 1.2 1 0 0 1 1 1 0 Peptidase family S64 TERB2 PF15101.6 EDP42283.1 - 8.7 6.3 14.2 19 5.2 14.2 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FAM176 PF14851.6 EDP42283.1 - 9.8 5.8 12.3 3 7.5 9.0 1.8 2 0 0 2 2 1 0 FAM176 family HECT PF00632.25 EDP42284.1 - 8.2e-68 229.1 0.0 1.2e-67 228.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SDA1 PF05285.12 EDP42284.1 - 0.71 9.2 11.3 1.3 8.3 11.3 1.3 1 0 0 1 1 1 0 SDA1 Herpes_LMP1 PF05297.11 EDP42284.1 - 0.84 8.8 11.1 1.4 8.1 11.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) HA2 PF04408.23 EDP42286.1 - 1e-22 80.5 0.0 3.6e-22 78.7 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDP42286.1 - 1.9e-15 57.0 0.0 5.2e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDP42286.1 - 3.8e-12 46.5 0.0 8.4e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP42286.1 - 2.3e-07 30.8 0.0 4.5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDP42286.1 - 4e-05 23.9 0.1 0.00012 22.3 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP42286.1 - 0.0013 18.5 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDP42286.1 - 0.0017 18.7 0.1 0.0038 17.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EDP42286.1 - 0.019 14.2 0.0 0.037 13.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EDP42286.1 - 0.023 14.6 0.2 0.25 11.3 0.1 2.3 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 EDP42286.1 - 0.031 13.3 0.0 0.079 12.0 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein HDC PF02329.16 EDP42286.1 - 0.051 12.6 0.0 0.089 11.8 0.0 1.3 1 0 0 1 1 1 0 Histidine carboxylase PI chain AAA_14 PF13173.6 EDP42286.1 - 0.063 13.3 0.1 0.66 10.0 0.1 2.4 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 EDP42286.1 - 0.092 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EDP42286.1 - 0.11 13.1 0.0 0.31 11.5 0.0 1.8 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 EDP42286.1 - 0.17 11.4 0.0 0.77 9.3 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Asp_protease PF09668.10 EDP42287.1 - 1.1e-57 193.2 0.0 1.6e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EDP42287.1 - 1.7e-22 79.8 0.0 3.7e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDP42287.1 - 2.5e-10 40.8 0.1 5.7e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease UBA_4 PF14555.6 EDP42287.1 - 6.6e-07 29.0 0.0 1.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain RVP PF00077.20 EDP42287.1 - 5.2e-05 23.5 0.0 0.00024 21.3 0.0 2.2 2 1 0 2 2 2 1 Retroviral aspartyl protease RVP_2 PF08284.11 EDP42287.1 - 6.2e-05 22.8 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Tropomyosin PF00261.20 EDP42287.1 - 0.0099 15.3 0.1 0.015 14.6 0.1 1.2 1 0 0 1 1 1 1 Tropomyosin RNB PF00773.19 EDP42288.1 - 7.6e-52 176.7 0.0 1.3e-51 175.9 0.0 1.4 1 0 0 1 1 1 1 RNB domain SHMT PF00464.19 EDP42289.1 - 3e-171 569.4 0.0 3.4e-171 569.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EDP42289.1 - 2.6e-06 26.9 0.1 1.1e-05 24.8 0.1 2.1 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EDP42289.1 - 0.0063 15.7 0.0 0.018 14.2 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II DUF4142 PF13628.6 EDP42289.1 - 0.14 12.4 1.5 0.19 12.0 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) STI1 PF17830.1 EDP42289.1 - 0.14 12.1 0.1 21 5.1 0.0 2.4 2 0 0 2 2 2 0 STI1 domain Kin17_mid PF10357.9 EDP42290.1 - 1.8e-45 153.9 0.1 2.9e-45 153.3 0.1 1.2 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein betaPIX_CC PF16523.5 EDP42290.1 - 0.0053 16.5 2.4 0.0072 16.1 1.4 1.7 2 0 0 2 2 2 1 betaPIX coiled coil Peptidase_M16 PF00675.20 EDP42291.1 - 3.7e-17 62.7 0.0 6.9e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDP42291.1 - 1.9e-11 44.3 0.0 3.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain 2-Hacid_dh PF00389.30 EDP42292.1 - 1.6e-19 69.9 0.0 1.7e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 EDP42292.1 - 4.8e-09 35.8 0.0 7.5e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RRM_1 PF00076.22 EDP42293.1 - 0.014 15.2 0.1 0.028 14.2 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GCD14 PF08704.10 EDP42293.1 - 0.14 11.8 0.2 0.19 11.4 0.2 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit ORC5_C PF14630.6 EDP42294.1 - 2.3e-48 165.2 0.0 2.6e-48 165.0 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DDDD PF10161.9 EDP42294.1 - 0.0073 16.0 0.0 5.2 6.9 0.0 2.4 2 0 0 2 2 2 2 Putative mitochondrial precursor protein TIP120 PF08623.10 EDP42294.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) Oxidored_FMN PF00724.20 EDP42295.1 - 7.2e-42 143.9 0.0 1.5e-37 129.7 0.0 2.1 2 0 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Pribosyl_synth PF14572.6 EDP42295.1 - 0.027 14.5 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain Oxidored_FMN PF00724.20 EDP42296.1 - 4.6e-42 144.5 0.0 1.1e-37 130.2 0.0 2.1 2 0 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Myb_DNA-binding PF00249.31 EDP42297.1 - 1.3e-12 47.7 0.0 4e-05 23.7 0.0 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EDP42297.1 - 2.9e-05 23.9 0.1 0.00045 20.0 0.0 2.5 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EDP42297.1 - 9e-05 22.7 0.2 0.47 10.8 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain UQ_con PF00179.26 EDP42298.1 - 1.4e-53 180.3 0.0 1.5e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDP42298.1 - 0.0022 18.3 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EDP42298.1 - 0.0074 16.0 0.0 0.0087 15.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDP42298.1 - 0.033 14.1 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain ELO PF01151.18 EDP42299.1 - 7.2e-47 160.0 25.3 8.9e-47 159.7 25.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ada3 PF10198.9 EDP42300.1 - 5.4e-22 78.3 3.1 5.4e-22 78.3 3.1 1.8 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 SSF PF00474.17 EDP42301.1 - 6.5e-05 22.0 15.9 0.00027 19.9 15.9 2.0 1 1 0 1 1 1 1 Sodium:solute symporter family PPP4R2 PF09184.11 EDP42302.1 - 7.8e-13 48.7 0.0 9.5e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 PPP4R2 Mg_trans_NIPA PF05653.14 EDP42303.1 - 2.8e-98 328.7 17.0 3.3e-98 328.4 17.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDP42303.1 - 5.3e-05 23.4 6.3 5.3e-05 23.4 6.3 3.3 3 1 0 3 3 3 1 EamA-like transporter family Trp_oprn_chp PF09534.10 EDP42303.1 - 1.2 8.9 4.3 7.8 6.3 0.0 3.0 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4131 PF13567.6 EDP42303.1 - 1.5 8.5 9.2 7.9 6.1 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF3671 PF12420.8 EDP42303.1 - 3.3 7.8 9.3 0.24 11.5 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function VirB8 PF04335.13 EDP42304.1 - 0.064 13.1 0.5 0.064 13.1 0.5 1.7 2 0 0 2 2 2 0 VirB8 protein CAP59_mtransfer PF11735.8 EDP42305.1 - 5.2e-65 219.5 0.0 6.4e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 FCH PF00611.23 EDP42306.1 - 1.3e-09 38.2 0.0 2.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2959 PF11172.8 EDP42306.1 - 1.5 9.0 6.0 1.7 8.7 0.3 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2959) RhoGAP PF00620.27 EDP42307.1 - 3.6e-05 23.7 0.1 4.6e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 RhoGAP domain DDDD PF10161.9 EDP42307.1 - 0.16 11.8 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Ribosomal_60s PF00428.19 EDP42308.1 - 3e-27 95.0 12.3 3.5e-27 94.8 12.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MT PF12777.7 EDP42308.1 - 0.056 12.5 0.5 0.062 12.3 0.5 1.1 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Cytomega_UL84 PF06284.11 EDP42308.1 - 0.49 8.8 3.0 0.6 8.5 3.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ribosomal_S19 PF00203.21 EDP42309.1 - 1.6e-16 59.9 0.1 2.3e-16 59.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.16 EDP42309.1 - 0.0028 17.7 0.0 0.0037 17.3 0.0 1.1 1 0 0 1 1 1 1 Flagellar assembly protein FliH ERCC4 PF02732.15 EDP42310.1 - 1.8e-21 77.0 0.0 2.9e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain Cytochrom_C1 PF02167.15 EDP42311.1 - 2.5e-96 321.6 0.0 3.2e-96 321.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EDP42311.1 - 0.0016 18.7 0.0 0.0036 17.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CPSase_L_D2 PF02786.17 EDP42312.1 - 5.4e-54 182.9 0.0 8.6e-54 182.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EDP42312.1 - 5.9e-27 94.4 0.0 1.6e-26 93.0 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDP42312.1 - 5.4e-20 71.5 0.0 1.7e-19 69.9 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 EDP42312.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EDP42312.1 - 0.0049 16.4 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EDP42312.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Asp PF00026.23 EDP42313.1 - 6.3e-23 81.7 0.0 1e-22 81.0 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EDP42313.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EDP42313.1 - 0.078 13.6 0.1 2 9.1 0.0 2.3 2 0 0 2 2 2 0 Aspartyl protease Gpr1_Fun34_YaaH PF01184.19 EDP42314.1 - 1.9e-45 155.0 17.9 2.2e-45 154.8 17.9 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 EDP42315.1 - 4.6e-73 245.2 17.6 5.5e-73 245.0 17.6 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family CAAD PF14159.6 EDP42315.1 - 0.065 13.1 0.3 0.16 11.9 0.3 1.7 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF4239 PF14023.6 EDP42315.1 - 2.9 7.5 5.4 3 7.5 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Gpr1_Fun34_YaaH PF01184.19 EDP42316.1 - 2e-69 233.4 16.8 2.3e-69 233.2 16.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Phosphoesterase PF04185.14 EDP42317.1 - 1.8e-79 267.5 3.5 2.4e-79 267.1 3.5 1.1 1 0 0 1 1 1 1 Phosphoesterase family Phosphoesterase PF04185.14 EDP42318.1 - 6.5e-75 252.5 4.2 1.1e-74 251.8 4.2 1.3 1 0 0 1 1 1 1 Phosphoesterase family Phosphoesterase PF04185.14 EDP42319.1 - 1.7e-76 257.7 4.0 2.3e-76 257.3 4.0 1.1 1 0 0 1 1 1 1 Phosphoesterase family Cu-oxidase PF00394.22 EDP42320.1 - 6.5e-31 107.6 0.0 1.2e-28 100.2 0.0 3.1 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP42320.1 - 2e-30 105.3 8.6 4.5e-21 75.1 0.6 3.7 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDP42320.1 - 1.6e-29 102.4 4.4 1.6e-29 102.4 4.4 3.0 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EDP42321.1 - 1.7e-31 108.7 5.2 1.3e-21 76.8 0.6 3.1 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EDP42321.1 - 6.8e-30 103.6 4.8 6.8e-30 103.6 4.8 2.7 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EDP42321.1 - 3e-26 92.4 0.1 1.3e-25 90.4 0.0 2.1 3 0 0 3 3 3 1 Multicopper oxidase RNA_lig_T4_1 PF09511.10 EDP42322.1 - 7.7e-79 264.6 0.0 1.7e-78 263.5 0.0 1.6 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 EDP42322.1 - 5.6e-30 104.6 0.0 1e-29 103.8 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 EDP42322.1 - 4.3e-24 85.3 0.0 4.3e-24 85.3 0.0 1.6 2 0 0 2 2 2 1 Fungal tRNA ligase phosphodiesterase domain PTPRCAP PF15713.5 EDP42322.1 - 0.24 11.7 5.3 0.5 10.7 5.3 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF3381 PF11861.8 EDP42322.1 - 7.4 6.4 10.8 19 5.0 10.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) TFIIA PF03153.13 EDP42324.1 - 1.3 8.9 27.3 1.5 8.7 27.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Herpes_gE PF02480.16 EDP42324.1 - 5.9 5.5 5.6 9.5 4.8 5.6 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E XPG_I_2 PF12813.7 EDP42325.1 - 1.9e-06 27.6 0.2 4.1e-05 23.2 0.0 2.5 2 0 0 2 2 2 1 XPG domain containing Tim54 PF11711.8 EDP42325.1 - 0.074 11.8 4.2 0.16 10.7 4.2 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RRP7 PF12923.7 EDP42325.1 - 0.29 11.3 0.0 0.29 11.3 0.0 2.5 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Choline_kinase PF01633.20 EDP42326.1 - 2.4e-36 125.4 0.0 3.7e-23 82.2 0.0 2.6 2 1 0 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 EDP42326.1 - 2.8e-06 27.5 0.1 0.012 15.6 0.0 3.2 2 1 0 2 2 2 2 Phosphotransferase enzyme family SOSSC PF15925.5 EDP42326.1 - 0.07 14.4 0.0 1.5 10.2 0.0 2.7 2 0 0 2 2 2 0 SOSS complex subunit C MAS20 PF02064.15 EDP42327.1 - 2.1e-25 89.3 3.3 2.1e-25 89.3 3.3 2.3 2 1 0 2 2 2 1 MAS20 protein import receptor Spore_coat_CotO PF14153.6 EDP42327.1 - 3 7.7 19.5 2.5 8.0 10.9 2.1 2 0 0 2 2 2 0 Spore coat protein CotO DUF3818 PF12825.7 EDP42328.1 - 2.2e-112 375.4 0.7 3.4e-112 374.8 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDP42328.1 - 7.3e-31 106.9 3.3 3.2e-30 104.8 3.3 2.1 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EDP42328.1 - 1.6e-13 50.6 0.0 5.7e-13 48.8 0.0 2.0 1 0 0 1 1 1 1 PX domain MutS_III PF05192.18 EDP42328.1 - 8.3 6.6 8.4 3.9 7.6 1.3 3.3 3 1 0 3 3 3 0 MutS domain III HSP70 PF00012.20 EDP42329.1 - 1.1e-260 866.0 14.7 1.3e-260 865.8 14.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDP42329.1 - 2.7e-15 56.0 3.8 2.4e-13 49.6 2.1 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDP42329.1 - 0.0028 18.1 8.5 0.22 12.0 0.6 3.9 3 1 0 3 3 3 2 Cell division protein FtsA Seryl_tRNA_N PF02403.22 EDP42329.1 - 0.061 13.6 5.9 0.19 12.0 5.9 1.9 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Tex_YqgF PF16921.5 EDP42329.1 - 0.097 13.1 0.9 0.28 11.6 0.9 1.8 1 0 0 1 1 1 0 Tex protein YqgF-like domain YTH PF04146.15 EDP42330.1 - 2.8e-51 173.8 0.5 7e-51 172.5 0.0 1.9 2 0 0 2 2 2 1 YT521-B-like domain RRM_1 PF00076.22 EDP42330.1 - 6e-05 22.8 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RWD PF05773.22 EDP42331.1 - 4e-09 36.8 9.4 1.1e-07 32.1 6.1 2.9 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EDP42331.1 - 0.00019 21.8 6.8 0.00019 21.8 6.8 3.0 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 Chalcone_2 PF16035.5 EDP42331.1 - 0.027 14.2 2.3 0.064 13.0 2.2 1.7 1 1 0 1 1 1 0 Chalcone isomerase like TP_methylase PF00590.20 EDP42331.1 - 0.038 13.9 0.3 0.13 12.2 0.0 1.9 1 1 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases SNX17_FERM_C PF18116.1 EDP42331.1 - 0.12 12.5 0.1 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain RPN7 PF10602.9 EDP42332.1 - 3e-14 53.1 0.1 5.1e-14 52.4 0.1 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EDP42332.1 - 0.002 18.6 0.0 0.0069 16.9 0.0 1.9 2 0 0 2 2 2 1 PCI domain TPR_1 PF00515.28 EDP42332.1 - 0.084 12.7 1.2 0.44 10.5 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42332.1 - 0.19 11.8 2.5 0.27 11.4 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42332.1 - 4.6 7.6 7.5 0.27 11.4 0.5 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat EST1_DNA_bind PF10373.9 EDP42333.1 - 2e-27 96.4 0.0 2.3e-24 86.4 0.0 3.1 3 1 0 3 3 3 2 Est1 DNA/RNA binding domain EST1 PF10374.9 EDP42333.1 - 2.9e-19 70.0 0.0 5.4e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Telomerase activating protein Est1 WD40 PF00400.32 EDP42334.1 - 2.2e-23 82.1 15.2 6.1e-05 23.7 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42335.1 - 0.00062 20.0 0.0 0.069 13.4 0.0 3.2 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDP42335.1 - 0.0046 17.8 0.0 0.097 13.6 0.0 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Lactonase PF10282.9 EDP42335.1 - 0.073 12.3 0.2 0.22 10.8 0.1 1.7 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Glutaredoxin PF00462.24 EDP42336.1 - 4.1e-17 62.1 0.0 6.5e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 EDP42336.1 - 0.00046 20.6 0.0 0.00061 20.1 0.0 1.3 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 EDP42336.1 - 0.0042 17.1 0.0 0.0081 16.2 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.6 EDP42336.1 - 0.0059 17.0 0.1 0.021 15.2 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 EDP42336.1 - 0.032 14.0 0.3 0.23 11.2 0.1 2.0 1 1 0 2 2 2 0 DSBA-like thioredoxin domain Rib_5-P_isom_A PF06026.14 EDP42337.1 - 1.8e-59 200.3 0.0 2.2e-59 200.0 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EDP42337.1 - 0.02 14.8 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 DeoR C terminal sensor domain Sugar-bind PF04198.13 EDP42337.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain WD40 PF00400.32 EDP42338.1 - 3.8e-31 106.6 16.8 2.7e-08 34.3 0.1 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42338.1 - 9.6e-10 38.6 0.1 0.041 14.2 0.0 4.5 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP42338.1 - 0.00048 19.2 0.0 0.16 10.9 0.0 2.7 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_2 PF07646.15 EDP42338.1 - 0.008 16.1 0.1 0.053 13.5 0.1 2.4 1 0 0 1 1 1 1 Kelch motif WD40_like PF17005.5 EDP42338.1 - 0.012 15.0 0.0 6.7 5.9 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain Kelch_6 PF13964.6 EDP42338.1 - 0.08 13.3 1.5 6.7 7.2 0.1 3.6 4 0 0 4 4 4 0 Kelch motif WDCP PF15390.6 EDP42338.1 - 0.1 11.0 0.1 0.13 10.6 0.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PQQ_3 PF13570.6 EDP42338.1 - 0.43 11.1 8.9 1.8 9.1 0.2 4.7 5 1 0 5 5 5 0 PQQ-like domain Sec10 PF07393.11 EDP42341.1 - 1e-71 242.4 2.4 8.3e-71 239.4 2.4 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.33 EDP42341.1 - 0.13 12.2 2.5 0.63 10.0 2.5 2.2 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EDP42341.1 - 0.27 11.1 7.6 0.28 11.1 2.0 3.0 2 1 0 2 2 2 0 F-box-like Spo7 PF03907.13 EDP42342.1 - 1.5e-21 77.0 7.2 2e-15 56.9 1.7 2.1 1 1 1 2 2 2 2 Spo7-like protein CBP4 PF07960.11 EDP42342.1 - 6.6 6.6 7.9 13 5.7 0.4 2.4 2 1 0 2 2 2 0 CBP4 BIR PF00653.21 EDP42343.1 - 3.1e-22 79.0 0.8 8.1e-22 77.7 0.8 1.8 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain 60KD_IMP PF02096.20 EDP42344.1 - 0.0017 18.3 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein DNA_ligase_OB_2 PF14743.6 EDP42345.1 - 9.6e-24 83.2 0.2 1.7e-23 82.4 0.2 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.21 EDP42345.1 - 2.3e-09 37.2 0.0 5.6e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EDP42345.1 - 0.00076 19.8 0.0 0.0021 18.4 0.0 1.7 1 1 0 1 1 1 1 RNA ligase Fer2_3 PF13085.6 EDP42346.1 - 2.8e-33 114.2 0.1 4.4e-33 113.5 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EDP42346.1 - 3.4e-09 37.1 5.2 3.4e-09 37.1 5.2 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDP42346.1 - 4.1e-07 30.4 7.1 4.1e-07 30.4 7.1 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDP42346.1 - 9.8e-07 28.8 3.6 9.8e-07 28.8 3.6 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EDP42346.1 - 0.00075 20.0 5.0 0.00075 20.0 5.0 2.3 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EDP42346.1 - 0.00097 19.0 0.4 0.00097 19.0 0.4 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_15 PF13459.6 EDP42346.1 - 0.29 11.9 4.8 7.1 7.5 0.6 2.6 3 0 0 3 3 3 0 4Fe-4S single cluster domain Fer4_9 PF13187.6 EDP42346.1 - 0.99 9.6 14.2 2.2 8.5 10.6 2.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain PHP PF02811.19 EDP42347.1 - 0.00025 21.4 0.0 0.00096 19.5 0.0 1.9 1 1 0 1 1 1 1 PHP domain IF4E PF01652.18 EDP42349.1 - 3.2e-47 160.3 0.0 4.8e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E ubiquitin PF00240.23 EDP42350.1 - 1.1e-07 31.5 0.3 1.8e-06 27.6 0.3 2.0 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 EDP42350.1 - 0.0029 18.0 0.1 0.097 13.1 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 EDP42350.1 - 0.0068 16.2 0.1 0.073 12.9 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UN_NPL4 PF11543.8 EDP42350.1 - 0.049 14.1 0.0 0.14 12.7 0.0 1.7 1 1 0 1 1 1 0 Nuclear pore localisation protein NPL4 TBK1_ULD PF18396.1 EDP42350.1 - 0.075 13.0 0.0 0.082 12.8 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain YukD PF08817.10 EDP42350.1 - 0.084 13.6 0.0 0.12 13.1 0.0 1.4 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_4 PF18036.1 EDP42350.1 - 0.19 11.8 0.0 2.7 8.1 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain Mito_carr PF00153.27 EDP42351.1 - 1.6e-38 130.5 0.2 8.5e-23 80.1 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Peptidase_S26 PF10502.9 EDP42352.1 - 3.6e-09 36.5 0.0 5.4e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EDP42352.1 - 0.00055 19.8 0.0 0.00099 19.0 0.0 1.6 1 1 0 1 1 1 1 Peptidase S24-like PAP2_3 PF14378.6 EDP42353.1 - 7e-22 78.0 15.9 7e-22 78.0 15.9 2.3 1 1 1 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EDP42353.1 - 4.7e-09 36.1 10.4 4.7e-09 36.1 10.4 2.1 2 1 1 3 3 3 1 PAP2 superfamily Pex14_N PF04695.13 EDP42353.1 - 0.67 10.6 4.0 0.97 10.1 4.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DEP PF00610.21 EDP42354.1 - 1.9e-18 66.3 0.1 3.6e-18 65.4 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) IML1 PF12257.8 EDP42355.1 - 4e-109 364.2 0.0 4.6e-109 363.9 0.0 1.0 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 Sec23_trunk PF04811.15 EDP42356.1 - 3.2e-73 246.3 0.0 4.5e-73 245.8 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EDP42356.1 - 9.6e-32 109.6 0.1 1.9e-31 108.7 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EDP42356.1 - 4e-26 90.8 0.1 8e-26 89.9 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDP42356.1 - 1.7e-15 56.8 4.7 4.1e-15 55.6 4.7 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDP42356.1 - 1.1e-12 47.6 0.0 2.3e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDP42356.1 - 0.037 13.4 0.1 0.082 12.3 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain WD40 PF00400.32 EDP42357.1 - 2.6e-11 43.9 7.3 4.6e-05 24.1 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat TagF_N PF09867.9 EDP42357.1 - 0.065 13.3 0.0 2.1 8.4 0.0 2.7 2 0 0 2 2 2 0 TagF N-terminal domain, Type VI secretion system-associated Ribosomal_L37ae PF01780.19 EDP42358.1 - 1.5e-39 134.0 8.1 2.1e-39 133.5 8.1 1.2 1 0 0 1 1 1 1 Ribosomal L37ae protein family DUF1364 PF07102.12 EDP42358.1 - 0.0039 17.0 0.4 0.0068 16.2 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1364) Zn_Tnp_IS1595 PF12760.7 EDP42358.1 - 0.044 13.8 3.2 0.057 13.4 1.7 1.9 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 EDP42358.1 - 0.083 13.4 1.9 0.43 11.1 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-ribbon_3 PF13248.6 EDP42358.1 - 0.27 10.7 3.5 7.7 6.1 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Sdh5 PF03937.16 EDP42359.1 - 2.9e-25 88.0 1.3 4.5e-25 87.4 1.3 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase IBN_N PF03810.19 EDP42360.1 - 3.8e-13 49.1 0.0 3e-12 46.3 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 EDP42360.1 - 6.6e-07 28.5 0.0 1.6e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Cse1 HEAT PF02985.22 EDP42360.1 - 0.0021 18.2 3.0 5.9 7.4 0.0 5.1 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 EDP42360.1 - 0.017 15.5 2.3 3.6 8.0 0.1 3.3 3 0 0 3 3 3 0 HEAT repeats Xpo1 PF08389.12 EDP42360.1 - 0.028 14.5 5.1 0.074 13.1 0.0 3.7 4 0 0 4 4 4 0 Exportin 1-like protein Vac14_Fab1_bd PF12755.7 EDP42360.1 - 0.051 14.2 2.6 0.77 10.4 0.0 4.1 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region ACTH_assoc PF16102.5 EDP42360.1 - 0.57 11.1 2.2 8.4 7.4 0.0 2.9 2 0 0 2 2 2 0 ACTH-associated domain DUF1216 PF06746.11 EDP42360.1 - 1 9.4 2.9 0.73 9.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) Rad17 PF03215.15 EDP42361.1 - 1e-07 32.1 0.0 0.002 18.1 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EDP42361.1 - 0.036 14.4 0.0 0.097 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain DAO PF01266.24 EDP42362.1 - 3.3e-45 155.2 0.2 4.9e-45 154.6 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EDP42362.1 - 5.9e-41 139.3 0.0 1.2e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EDP42362.1 - 7.1e-07 28.6 1.8 0.014 14.5 0.8 2.5 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EDP42362.1 - 0.0037 16.7 0.8 0.0062 15.9 0.2 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP42362.1 - 0.0062 15.8 0.2 0.013 14.8 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDP42362.1 - 0.02 15.1 0.3 0.28 11.5 0.3 2.7 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EDP42362.1 - 0.13 11.3 0.1 0.77 8.8 0.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EDP42362.1 - 0.22 10.7 0.0 0.42 9.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Brix PF04427.18 EDP42363.1 - 1.1e-29 103.9 0.1 1.5e-29 103.5 0.1 1.2 1 0 0 1 1 1 1 Brix domain Ribosomal_L28 PF00830.19 EDP42364.1 - 4.1e-18 65.3 1.4 1.7e-17 63.3 0.4 2.1 2 0 0 2 2 2 1 Ribosomal L28 family ATP-synt_ab PF00006.25 EDP42365.1 - 1.7e-68 230.5 0.0 2.4e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDP42365.1 - 2.9e-10 40.5 0.1 6.3e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3533 PF12051.8 EDP42365.1 - 0.023 13.6 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF561 PF04481.12 EDP42365.1 - 0.18 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) 4HBT_3 PF13622.6 EDP42366.1 - 3.8e-36 125.6 0.1 5.6e-36 125.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDP42366.1 - 0.009 15.9 0.0 0.036 13.9 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA thioesterase Stimulus_sens_1 PF13756.6 EDP42366.1 - 0.1 13.2 0.0 12 6.5 0.0 2.4 2 0 0 2 2 2 0 Stimulus-sensing domain Motile_Sperm PF00635.26 EDP42367.1 - 7.4e-26 90.1 0.1 1.1e-25 89.6 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 EDP42367.1 - 0.00074 19.7 0.1 0.0016 18.6 0.1 1.5 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF3618 PF12277.8 EDP42367.1 - 0.086 13.1 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3618) AJAP1_PANP_C PF15298.6 EDP42367.1 - 0.95 9.7 5.8 1.7 8.8 5.8 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus SelP_N PF04592.14 EDP42368.1 - 4.6 6.6 15.2 5.2 6.4 15.2 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ORC2 PF04084.14 EDP42369.1 - 5.3e-41 140.6 0.0 7.9e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 SQS_PSY PF00494.19 EDP42370.1 - 1.5e-45 155.8 0.0 5.5e-45 153.9 0.0 1.7 1 1 0 1 1 1 1 Squalene/phytoene synthase Pkinase PF00069.25 EDP42371.1 - 1e-64 218.5 0.0 1.2e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42371.1 - 7.1e-38 130.4 0.0 1.2e-37 129.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP42371.1 - 2e-05 23.7 0.1 3.2e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDP42371.1 - 3.3e-05 22.8 0.0 5.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP42371.1 - 0.00011 21.6 0.0 0.00025 20.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDP42371.1 - 0.014 15.0 0.2 0.034 13.7 0.1 1.7 2 0 0 2 2 2 0 RIO1 family Seadorna_VP7 PF07387.11 EDP42371.1 - 0.04 13.0 0.1 0.064 12.3 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EDP42371.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RasGEF PF00617.19 EDP42372.1 - 3.2e-41 141.4 0.0 6.2e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDP42372.1 - 4.5e-06 26.9 0.2 1.4e-05 25.2 0.2 1.9 1 1 0 1 1 1 1 RasGEF N-terminal motif Mito_carr PF00153.27 EDP42373.1 - 2.2e-47 158.9 1.7 1.2e-16 60.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDP42373.1 - 0.22 10.6 1.1 13 4.8 0.1 2.7 2 1 0 3 3 3 0 Gammaproteobacterial serine protease 2-oxoacid_dh PF00198.23 EDP42374.1 - 1.6e-79 266.6 0.0 2.5e-79 266.0 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDP42374.1 - 1.3e-18 66.6 1.5 2.2e-18 65.8 1.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 EDP42374.1 - 5.3e-05 23.9 0.0 0.05 14.3 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 EDP42374.1 - 0.012 15.5 0.3 0.027 14.3 0.3 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.6 EDP42374.1 - 0.019 14.8 0.0 0.86 9.5 0.0 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like Presenilin PF01080.17 EDP42374.1 - 0.13 11.0 9.5 0.18 10.6 9.5 1.1 1 0 0 1 1 1 0 Presenilin HlyD_D23 PF16576.5 EDP42374.1 - 0.13 11.4 1.7 0.82 8.8 0.0 2.5 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion CDC45 PF02724.14 EDP42374.1 - 0.7 8.1 13.8 0.93 7.7 13.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 EDP42374.1 - 1.9 8.5 4.5 2.5 8.1 4.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GAGA_bind PF06217.12 EDP42374.1 - 2.2 8.5 8.3 3 8.0 8.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family SLC12 PF03522.15 EDP42374.1 - 7.9 5.4 7.6 10 5.0 7.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Lipoprotein_20 PF13942.6 EDP42375.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.5 1 1 1 2 2 2 0 YfhG lipoprotein DUF3053 PF11254.8 EDP42375.1 - 0.13 11.9 5.8 3.4 7.2 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) FAM76 PF16046.5 EDP42375.1 - 0.18 11.1 2.5 0.33 10.2 2.5 1.4 1 0 0 1 1 1 0 FAM76 protein COG2 PF06148.11 EDP42375.1 - 0.31 11.1 5.4 2.6 8.1 0.3 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 LXG PF04740.12 EDP42375.1 - 0.33 10.6 4.1 0.79 9.4 1.6 2.2 1 1 1 2 2 2 0 LXG domain of WXG superfamily DivIC PF04977.15 EDP42375.1 - 0.62 9.9 5.0 5 7.0 0.8 3.0 2 0 0 2 2 2 0 Septum formation initiator TMF_TATA_bd PF12325.8 EDP42375.1 - 1.7 8.8 11.7 0.71 10.1 1.2 3.0 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding RRF PF01765.19 EDP42375.1 - 3.1 7.7 9.3 0.21 11.5 1.7 2.5 1 1 2 3 3 3 0 Ribosome recycling factor HIP1_clath_bdg PF16515.5 EDP42375.1 - 3.5 8.3 11.9 16 6.2 0.4 2.8 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PHD PF00628.29 EDP42376.1 - 7.3e-07 29.0 5.7 7.8e-06 25.7 2.6 2.7 2 1 1 3 3 3 1 PHD-finger C1_1 PF00130.22 EDP42376.1 - 0.023 14.6 2.1 0.023 14.6 2.1 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHF12_MRG_bd PF16737.5 EDP42376.1 - 0.027 14.2 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain FdhE PF04216.12 EDP42376.1 - 0.094 12.6 0.3 0.17 11.7 0.3 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation PHD_2 PF13831.6 EDP42376.1 - 1.2 8.8 5.5 1.8 8.2 0.1 3.0 3 0 0 3 3 3 0 PHD-finger PHD_4 PF16866.5 EDP42376.1 - 7.8 6.7 9.2 0.22 11.7 1.8 2.2 3 0 0 3 3 3 0 PHD-finger Vps51 PF08700.11 EDP42377.1 - 1.5e-11 44.2 0.6 3.7e-11 42.9 0.6 1.7 1 0 0 1 1 1 1 Vps51/Vps67 Flt3_lig PF02947.14 EDP42377.1 - 0.01 16.0 0.3 0.38 10.9 0.1 3.2 3 0 0 3 3 3 0 flt3 ligand TED_complement PF07678.14 EDP42377.1 - 0.19 10.8 3.4 0.36 9.8 0.1 2.7 3 0 0 3 3 3 0 A-macroglobulin TED domain Synaptobrevin PF00957.21 EDP42378.1 - 2.5e-14 52.8 0.2 4e-14 52.2 0.2 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EDP42378.1 - 4.1e-12 46.0 0.0 8.1e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_teg_N PF04843.12 EDP42378.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region UPF0258 PF06789.12 EDP42379.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Pkinase PF00069.25 EDP42380.1 - 5.4e-66 222.7 0.0 8.9e-66 221.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42380.1 - 3.5e-35 121.5 0.0 3.7e-34 118.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EDP42380.1 - 0.00043 19.4 0.1 0.00074 18.7 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EDP42380.1 - 0.00044 20.2 0.1 0.00044 20.2 0.1 3.4 4 1 1 5 5 5 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP42380.1 - 0.00052 19.4 0.1 0.003 16.9 0.1 2.2 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDP42380.1 - 0.0055 15.5 0.0 0.02 13.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase RIC1 PF07064.13 EDP42381.1 - 8.3e-73 244.9 0.0 1.2e-72 244.3 0.0 1.3 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EDP42381.1 - 6e-05 23.3 0.0 0.0035 17.6 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EDP42381.1 - 0.048 13.6 0.0 0.17 11.9 0.0 2.0 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Mito_carr PF00153.27 EDP42382.1 - 6.2e-52 173.5 0.3 3.6e-19 68.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein E1-E2_ATPase PF00122.20 EDP42383.1 - 3.4e-20 72.3 0.0 8.6e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EDP42383.1 - 8.6e-14 52.3 0.0 2.6e-07 31.2 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDP42383.1 - 0.0091 16.1 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDP42383.1 - 0.032 14.0 0.0 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SieB PF14163.6 EDP42383.1 - 0.51 9.8 0.0 0.51 9.8 0.0 2.9 3 0 0 3 3 3 0 Super-infection exclusion protein B Pkinase PF00069.25 EDP42384.1 - 1.1e-65 221.7 0.0 2.1e-65 220.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42384.1 - 1e-43 149.5 0.0 1.9e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EDP42384.1 - 1.2e-13 51.2 0.0 2.5e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 RA PF00788.23 EDP42384.1 - 0.0006 20.4 0.0 0.0011 19.6 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.6 EDP42384.1 - 0.001 18.5 0.2 0.018 14.3 0.1 2.7 3 1 0 3 3 3 1 Kinase-like Planc_extracel PF07595.12 EDP42384.1 - 0.0086 15.8 1.3 0.044 13.6 1.3 2.3 1 0 0 1 1 1 1 Planctomycete extracellular Pkinase_fungal PF17667.1 EDP42384.1 - 0.027 13.2 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Hydantoinase_B PF02538.14 EDP42385.1 - 3.7e-215 715.2 0.1 4.2e-215 715.0 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase DPBB_1 PF03330.18 EDP42387.1 - 0.0011 19.2 0.4 0.0029 17.9 0.0 2.0 2 1 0 2 2 2 1 Lytic transglycolase Utp14 PF04615.13 EDP42387.1 - 3.7 6.0 20.5 4.8 5.6 20.5 1.0 1 0 0 1 1 1 0 Utp14 protein Sugar_tr PF00083.24 EDP42388.1 - 7.4e-103 344.8 7.7 9e-103 344.5 7.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP42388.1 - 2.3e-18 66.3 14.7 2.3e-18 66.3 14.7 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EDP42388.1 - 0.0011 17.3 1.4 0.0025 16.2 1.4 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF2079 PF09852.9 EDP42388.1 - 0.043 12.7 2.9 0.096 11.5 2.9 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Trp_oprn_chp PF09534.10 EDP42388.1 - 0.049 13.4 0.2 5.7 6.7 0.0 2.5 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2530 PF10745.9 EDP42388.1 - 8.2 6.7 11.8 0.46 10.8 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) BLM10_mid PF16507.5 EDP42389.1 - 3.3e-162 540.8 0.0 5.9e-162 540.0 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region TPR_20 PF14561.6 EDP42389.1 - 0.0076 16.6 0.0 0.031 14.6 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3437 PF11919.8 EDP42390.1 - 1.4e-26 92.2 0.2 1.1e-25 89.3 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT PF02985.22 EDP42390.1 - 0.0021 18.2 0.2 0.0074 16.5 0.0 2.1 2 0 0 2 2 2 1 HEAT repeat HEAT_EZ PF13513.6 EDP42390.1 - 0.0037 17.7 0.1 1 9.9 0.0 3.2 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.6 EDP42390.1 - 0.0038 17.6 0.3 0.22 11.9 0.0 2.4 2 0 0 2 2 2 1 HEAT repeats IFRD PF05004.13 EDP42390.1 - 0.075 12.1 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) UPF0061 PF02696.14 EDP42391.1 - 3.8e-94 316.1 0.0 5e-94 315.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family INCENP_ARK-bind PF03941.15 EDP42391.1 - 0.27 11.2 0.9 1 9.3 0.1 2.4 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region Mannosyl_trans PF05007.13 EDP42392.1 - 5.5e-38 131.3 0.3 9.6e-38 130.5 0.3 1.4 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EDP42392.1 - 9.6e-09 34.8 0.0 1.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U CorA PF01544.18 EDP42393.1 - 8.1e-44 150.1 0.9 1.1e-43 149.7 0.9 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SUR7 PF06687.12 EDP42394.1 - 9e-16 58.1 0.6 1e-15 57.9 0.6 1.1 1 0 0 1 1 1 1 SUR7/PalI family NADH5_C PF06455.11 EDP42394.1 - 0.029 13.9 1.3 0.041 13.5 1.3 1.2 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus S_4TM PF18159.1 EDP42394.1 - 0.28 10.5 2.4 0.34 10.2 1.7 1.4 1 1 0 1 1 1 0 SMODS-associating 4TM effector domain DUF805 PF05656.14 EDP42394.1 - 0.43 11.0 3.3 0.6 10.5 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF373 PF04123.13 EDP42394.1 - 0.75 9.2 5.2 1 8.7 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) GPI-anchored PF10342.9 EDP42395.1 - 3.3e-07 31.0 0.0 5.9e-07 30.2 0.0 1.4 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Acyl-CoA_dh_1 PF00441.24 EDP42396.1 - 4.1e-48 163.4 1.8 6.1e-48 162.8 1.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EDP42396.1 - 3.7e-28 97.6 0.0 8.2e-28 96.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EDP42396.1 - 2.9e-24 85.9 0.0 5.5e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EDP42396.1 - 3.4e-17 63.0 0.8 6.1e-17 62.1 0.8 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EDP42396.1 - 0.0007 19.3 0.0 0.0037 17.0 0.0 2.1 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal CBS PF00571.28 EDP42397.1 - 4.2e-28 97.6 5.3 1e-06 29.1 0.2 4.8 4 0 0 4 4 4 4 CBS domain PB1 PF00564.24 EDP42397.1 - 0.00042 20.2 0.2 0.001 18.9 0.2 1.6 1 0 0 1 1 1 1 PB1 domain MMR_HSR1_Xtn PF16897.5 EDP42398.1 - 1.2e-41 141.0 0.4 2.2e-41 140.2 0.4 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EDP42398.1 - 1.9e-19 69.8 0.0 4.2e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EDP42398.1 - 1.9e-18 66.2 0.1 3.5e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EDP42398.1 - 1.9e-10 40.5 0.0 3.6e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDP42398.1 - 0.0032 17.5 0.3 0.97 9.5 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AAA_28 PF13521.6 EDP42398.1 - 0.018 15.3 0.3 0.049 13.9 0.3 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EDP42398.1 - 0.043 14.4 0.0 0.097 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EDP42398.1 - 0.068 13.4 0.0 0.24 11.6 0.0 2.1 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EDP42398.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 AIG1 family MCM PF00493.23 EDP42398.1 - 0.071 12.2 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_16 PF13191.6 EDP42398.1 - 0.077 13.4 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EDP42398.1 - 0.1 12.5 0.3 0.75 9.7 0.0 2.4 2 1 1 3 3 3 0 RsgA GTPase LCAT PF02450.15 EDP42399.1 - 3.6e-61 207.5 0.2 4.7e-61 207.1 0.2 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EDP42399.1 - 0.0089 16.7 1.3 0.017 15.7 1.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EDP42399.1 - 0.062 13.0 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.8 EDP42399.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DnaJ PF00226.31 EDP42401.1 - 1e-18 67.2 0.1 1.4e-18 66.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 EDP42401.1 - 9.9e-11 41.2 0.4 1.7e-10 40.5 0.4 1.4 1 0 0 1 1 1 1 CSL zinc finger AviRa PF11599.8 EDP42401.1 - 0.061 12.8 0.2 0.096 12.1 0.2 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Peptidase_C48 PF02902.19 EDP42402.1 - 2.7e-36 125.5 0.0 6.8e-36 124.1 0.0 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SGT1 PF07093.11 EDP42403.1 - 6e-58 196.7 24.5 1.5e-56 192.1 24.5 2.9 1 1 0 1 1 1 1 SGT1 protein ARA70 PF12489.8 EDP42403.1 - 2.1 8.6 7.2 0.39 10.9 0.5 2.7 3 0 0 3 3 3 0 Nuclear coactivator Complex1_30kDa PF00329.19 EDP42404.1 - 4.6e-46 156.4 0.0 6.5e-46 155.9 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit BCAS2 PF05700.11 EDP42405.1 - 7.7e-54 182.5 8.6 1e-53 182.1 8.6 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Rrp15p PF07890.12 EDP42406.1 - 2.5e-33 115.3 1.9 2.5e-33 115.3 1.9 2.0 2 1 0 2 2 2 1 Rrp15p CDC45 PF02724.14 EDP42406.1 - 3.1e-05 22.5 16.5 4.7e-05 21.9 16.5 1.3 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 EDP42406.1 - 0.00047 18.5 20.5 0.00065 18.1 20.5 1.3 1 0 0 1 1 1 1 Nop14-like family Nop53 PF07767.11 EDP42406.1 - 0.0052 16.2 14.0 0.0052 16.2 14.0 1.8 2 0 0 2 2 2 1 Nop53 (60S ribosomal biogenesis) DNA_pol_phi PF04931.13 EDP42406.1 - 0.11 10.5 29.3 0.16 10.1 29.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 EDP42406.1 - 0.79 9.4 12.0 1.9 8.2 12.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Roughex PF06020.11 EDP42406.1 - 2.2 7.3 14.1 3.5 6.6 14.1 1.3 1 0 0 1 1 1 0 Drosophila roughex protein ATP-grasp_2 PF08442.10 EDP42407.1 - 4.9e-70 235.2 1.6 2.1e-69 233.1 0.1 2.0 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EDP42407.1 - 1.7e-23 83.1 1.0 6.5e-23 81.2 1.1 1.9 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 EDP42407.1 - 2.2e-09 37.1 0.5 6.2e-09 35.6 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EDP42407.1 - 0.0048 16.7 0.5 0.013 15.3 0.1 1.9 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 EDP42407.1 - 0.031 13.8 0.0 0.084 12.4 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain HipA_C PF07804.12 EDP42407.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 HipA-like C-terminal domain Ribosomal_S8 PF00410.19 EDP42408.1 - 1.1e-14 54.4 0.0 1.5e-13 50.8 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8 Methyltransf_31 PF13847.6 EDP42409.1 - 4.4e-13 49.3 0.0 5.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EDP42409.1 - 5.9e-06 26.3 0.0 8.1e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP42409.1 - 2.4e-05 24.9 0.0 9.5e-05 23.0 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP42409.1 - 0.00052 20.7 0.0 0.001 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP42409.1 - 0.0028 17.5 0.0 0.0064 16.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP42409.1 - 0.0039 17.8 0.0 0.033 14.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDP42409.1 - 0.025 14.1 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain DREV PF05219.12 EDP42409.1 - 0.047 12.8 0.0 0.73 8.9 0.0 2.0 2 0 0 2 2 2 0 DREV methyltransferase Ribosomal_S27e PF01667.17 EDP42410.1 - 1.1e-23 82.7 3.0 1.1e-23 82.6 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EDP42410.1 - 0.043 13.3 0.2 0.056 13.0 0.2 1.1 1 0 0 1 1 1 0 TFIIB zinc-binding zf-C3HC4_3 PF13920.6 EDP42410.1 - 0.078 12.9 1.5 0.13 12.1 1.5 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_4 PF13717.6 EDP42410.1 - 0.099 12.6 1.5 1.8 8.6 1.5 2.4 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_L19e PF01280.20 EDP42411.1 - 6.7e-62 207.8 10.0 6.7e-62 207.8 10.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e DUF5427 PF10310.9 EDP42412.1 - 1.7e-17 63.5 24.9 1.1e-09 37.8 19.2 3.5 1 1 1 2 2 2 2 Family of unknown function (DUF5427) TSP9 PF11493.8 EDP42412.1 - 0.072 13.8 0.3 0.3 11.8 0.1 2.2 1 1 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 Phage_GP20 PF06810.11 EDP42412.1 - 0.25 11.1 0.8 0.37 10.6 0.0 1.6 2 0 0 2 2 2 0 Phage minor structural protein GP20 Retinal PF15449.6 EDP42412.1 - 3.3 5.4 39.0 6.9 4.3 39.0 1.5 1 0 0 1 1 1 0 Retinal protein Metallophos PF00149.28 EDP42413.1 - 2e-36 126.4 0.3 5.5e-35 121.7 0.1 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDP42413.1 - 0.015 15.8 0.1 0.06 13.8 0.0 2.1 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain cwf21 PF08312.12 EDP42413.1 - 0.076 13.2 0.0 0.67 10.2 0.0 2.5 2 0 0 2 2 2 0 cwf21 domain DUF1647 PF07801.11 EDP42413.1 - 0.22 11.3 1.6 3.3 7.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Proteasome PF00227.26 EDP42414.1 - 4.4e-32 111.1 0.1 5.7e-32 110.7 0.1 1.3 1 1 0 1 1 1 1 Proteasome subunit UBA PF00627.31 EDP42415.1 - 2.1e-06 27.5 0.2 2.1e-06 27.5 0.2 2.7 3 0 0 3 3 3 1 UBA/TS-N domain HOIP-UBA PF16678.5 EDP42415.1 - 0.022 14.8 0.0 0.057 13.4 0.0 1.7 1 0 0 1 1 1 0 HOIP UBA domain pair GerD PF17898.1 EDP42415.1 - 0.045 13.7 3.7 0.089 12.7 3.7 1.5 1 1 0 1 1 1 0 Spore germination GerD central core domain STI1 PF17830.1 EDP42415.1 - 2.5 8.1 15.4 0.77 9.7 2.6 3.7 2 1 0 3 3 3 0 STI1 domain HAD_2 PF13419.6 EDP42416.1 - 2.2e-13 50.7 0.0 3.7e-13 50.0 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDP42416.1 - 2.1e-06 27.7 0.1 6.6e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EDP42416.1 - 0.0097 16.2 0.0 0.017 15.4 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDP42417.1 - 6.3e-07 29.7 0.0 8.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDP42417.1 - 4.7e-05 23.8 0.0 6.2e-05 23.4 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDP42417.1 - 0.0018 18.7 0.0 0.0025 18.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase tRNA-synt_1_2 PF13603.6 EDP42417.1 - 0.058 12.9 0.0 0.092 12.2 0.0 1.3 1 1 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 AMPKBI PF04739.15 EDP42418.1 - 2.1e-26 92.0 3.3 3.7e-26 91.2 0.8 2.5 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EDP42418.1 - 2.3e-26 91.8 0.0 4.6e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM53 PF16760.5 EDP42418.1 - 0.059 14.0 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) HDPD PF02924.14 EDP42418.1 - 0.12 12.5 0.1 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage lambda head decoration protein D zf-ANAPC11 PF12861.7 EDP42419.1 - 2.2e-23 82.1 10.0 2.8e-23 81.8 10.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EDP42419.1 - 6.7e-20 71.1 11.3 8.9e-20 70.7 11.3 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EDP42419.1 - 2e-07 31.2 14.3 3.3e-06 27.3 14.3 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDP42419.1 - 7.1e-06 25.8 9.5 1.6e-05 24.6 9.5 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDP42419.1 - 0.0011 18.8 16.8 0.0012 18.6 12.7 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP42419.1 - 0.0049 17.0 8.6 0.011 15.9 3.4 2.5 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDP42419.1 - 0.0076 16.3 8.3 0.0077 16.2 6.0 2.0 1 1 1 2 2 2 1 RING-type zinc-finger RecR PF02132.15 EDP42419.1 - 0.014 15.0 3.8 0.19 11.3 1.4 2.6 2 1 0 2 2 2 0 RecR protein zf-RING_4 PF14570.6 EDP42419.1 - 0.049 13.4 2.4 0.049 13.4 2.4 2.5 1 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EDP42419.1 - 0.052 13.5 12.8 0.045 13.7 7.7 2.2 2 1 0 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.8 EDP42419.1 - 0.064 13.4 12.7 0.5 10.6 12.7 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 EDP42419.1 - 0.084 12.7 3.4 0.18 11.7 3.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-HC5HC2H_2 PF13832.6 EDP42419.1 - 0.14 12.3 6.3 0.04 14.1 3.7 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING-like PF08746.11 EDP42419.1 - 0.15 12.4 10.0 0.41 11.0 10.0 1.9 1 1 0 1 1 1 0 RING-like domain zf-HC5HC2H PF13771.6 EDP42419.1 - 0.43 10.8 6.9 1.5 9.1 7.3 1.8 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING_11 PF17123.5 EDP42419.1 - 0.43 10.4 10.7 4.5 7.1 10.7 2.2 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EDP42419.1 - 1.4 8.6 13.4 12 5.6 12.8 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zn-ribbon_8 PF09723.10 EDP42419.1 - 4.4 7.5 8.4 4.9 7.4 0.6 2.3 2 0 0 2 2 2 0 Zinc ribbon domain RINGv PF12906.7 EDP42419.1 - 4.5 7.5 11.7 18 5.6 11.9 2.0 1 1 0 1 1 1 0 RING-variant domain Kinesin PF00225.23 EDP42420.1 - 1.1e-47 162.7 0.0 2.3e-47 161.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDP42420.1 - 5.4e-44 149.7 0.0 1.1e-43 148.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding EzrA PF06160.12 EDP42420.1 - 0.0012 17.2 4.8 0.0017 16.6 4.8 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4201 PF13870.6 EDP42420.1 - 0.0049 16.6 8.1 0.0049 16.6 8.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4201) BRE1 PF08647.11 EDP42420.1 - 0.022 14.8 2.3 0.022 14.8 2.3 2.6 4 0 0 4 4 3 0 BRE1 E3 ubiquitin ligase Spc29 PF17082.5 EDP42420.1 - 0.19 11.5 11.8 0.57 10.0 0.3 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 FAM76 PF16046.5 EDP42420.1 - 0.41 10.0 8.5 0.63 9.4 8.5 1.2 1 0 0 1 1 1 0 FAM76 protein Phage_GP20 PF06810.11 EDP42420.1 - 0.45 10.3 6.0 0.06 13.2 1.5 1.7 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF641 PF04859.12 EDP42420.1 - 0.5 10.7 13.5 1.8 8.9 5.0 3.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ERM PF00769.19 EDP42420.1 - 0.84 9.4 26.1 0.075 12.8 11.4 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family AAA_16 PF13191.6 EDP42420.1 - 1.2 9.5 0.0 1.2 9.5 0.0 3.1 3 1 0 3 3 2 0 AAA ATPase domain CENP-F_leu_zip PF10473.9 EDP42420.1 - 1.5 8.8 17.5 0.027 14.5 8.6 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EDP42420.1 - 4.5 7.8 22.1 1 9.9 13.2 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region PKcGMP_CC PF16808.5 EDP42420.1 - 6.4 6.7 12.6 0.37 10.7 1.6 3.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran_CTD PF16326.5 EDP42421.1 - 2.8e-05 24.3 35.6 0.0046 17.2 3.2 6.0 5 1 2 7 7 7 3 ABC transporter C-terminal domain DUF603 PF04645.12 EDP42421.1 - 0.013 15.2 3.0 0.19 11.4 0.5 2.7 2 2 1 3 3 3 0 Protein of unknown function, DUF603 DUF4407 PF14362.6 EDP42421.1 - 0.11 11.8 40.1 0.45 9.8 9.8 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) EzrA PF06160.12 EDP42421.1 - 0.96 7.5 27.0 0.61 8.2 23.2 2.3 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF4363 PF14276.6 EDP42421.1 - 1.1 9.4 12.6 0.16 12.1 3.9 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4363) NPV_P10 PF05531.12 EDP42421.1 - 1.1 9.7 13.8 1.8 9.1 0.5 4.9 3 1 2 5 5 5 0 Nucleopolyhedrovirus P10 protein Hemerythrin PF01814.23 EDP42421.1 - 2.6 8.7 19.6 9.2 6.9 0.3 4.1 2 2 2 4 4 4 0 Hemerythrin HHE cation binding domain DUF948 PF06103.11 EDP42421.1 - 7 7.0 12.7 1.1 9.6 0.7 4.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 EDP42421.1 - 7.2 6.7 9.7 44 4.1 0.8 3.8 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pkinase PF00069.25 EDP42422.1 - 3.5e-66 223.3 0.0 4.3e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42422.1 - 2.7e-33 115.3 0.0 3.5e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP42422.1 - 0.00016 21.1 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP42422.1 - 0.0034 17.3 0.1 0.99 9.3 0.0 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP42422.1 - 0.0067 15.4 0.0 0.042 12.8 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain BHD_3 PF10405.9 EDP42424.1 - 2.7e-26 91.8 0.0 6.2e-26 90.6 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 EDP42424.1 - 3e-24 85.4 0.2 6.1e-24 84.4 0.2 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 EDP42424.1 - 1.7e-16 59.8 0.0 3.8e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EDP42424.1 - 2e-15 57.5 0.7 2e-15 57.5 0.7 3.9 4 1 0 4 4 4 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EDP42424.1 - 7e-09 36.1 0.1 2.7e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Transglutaminase-like superfamily EDR1 PF14381.6 EDP42424.1 - 0.026 14.2 0.1 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 DUF3801 PF12687.7 EDP42424.1 - 0.4 10.7 3.6 1.7 8.7 3.6 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3801) DUF747 PF05346.11 EDP42425.1 - 4.1e-112 374.8 4.9 6.7e-112 374.1 4.9 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family Ebp2 PF05890.12 EDP42427.1 - 6.6e-87 291.5 9.4 6.6e-87 291.5 9.4 2.2 2 1 1 3 3 3 1 Eukaryotic rRNA processing protein EBP2 CENP-B_dimeris PF09026.10 EDP42427.1 - 0.033 14.6 2.7 0.033 14.6 2.7 8.1 3 1 4 7 7 7 0 Centromere protein B dimerisation domain RGS-like PF09128.11 EDP42427.1 - 0.3 10.8 3.8 0.83 9.3 3.8 1.8 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Leo1 PF04004.13 EDP42428.1 - 6e-47 159.6 3.8 2.4e-46 157.6 3.8 2.1 1 1 0 1 1 1 1 Leo1-like protein BUD22 PF09073.10 EDP42428.1 - 0.019 14.4 47.4 0.32 10.3 21.1 2.1 2 0 0 2 2 2 0 BUD22 zf-C2H2 PF00096.26 EDP42430.1 - 5.2e-09 36.1 14.0 0.0005 20.4 3.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDP42430.1 - 1.2e-07 31.9 16.8 7.3e-05 23.0 4.4 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDP42430.1 - 8.1e-05 23.1 11.2 0.046 14.6 1.8 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EDP42430.1 - 0.085 13.5 0.3 0.28 11.8 0.3 1.9 1 0 0 1 1 1 0 FOXP coiled-coil domain G6PD_C PF02781.16 EDP42431.1 - 1.5e-103 346.0 0.0 2.3e-103 345.4 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EDP42431.1 - 1.3e-35 123.7 0.1 1.9e-35 123.1 0.1 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Sod_Fe_C PF02777.18 EDP42432.1 - 4.1e-36 123.2 0.5 7.3e-36 122.4 0.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EDP42432.1 - 1e-17 64.4 5.9 1e-17 64.4 5.9 1.9 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain zf-RING_UBOX PF13445.6 EDP42433.1 - 1.2e-09 38.0 2.9 1.2e-09 38.0 2.9 1.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDP42433.1 - 3.3e-08 33.3 2.5 3.3e-08 33.3 2.5 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP42433.1 - 1.2e-07 31.6 3.8 1.2e-07 31.6 3.8 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDP42433.1 - 3.4e-07 30.0 3.6 3.4e-07 30.0 3.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP42433.1 - 3.2e-05 24.2 11.2 3.2e-05 24.2 11.2 3.0 2 1 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.6 EDP42433.1 - 0.00021 21.1 1.4 0.00021 21.1 1.4 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EDP42433.1 - 0.00023 21.3 5.3 0.00023 21.3 5.3 2.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EDP42433.1 - 0.00084 19.2 11.0 0.00084 19.2 11.0 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDP42433.1 - 0.0067 16.3 5.0 0.0067 16.3 5.0 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 Tmpp129 PF10272.9 EDP42433.1 - 0.0093 15.3 3.2 0.014 14.7 3.2 1.2 1 0 0 1 1 1 1 Putative transmembrane protein precursor PhnA_Zn_Ribbon PF08274.12 EDP42433.1 - 0.019 14.9 0.2 1.4 8.9 0.0 2.7 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Trm112p PF03966.16 EDP42433.1 - 0.19 12.3 1.1 0.65 10.6 0.2 2.3 2 1 0 2 2 1 0 Trm112p-like protein FYVE PF01363.21 EDP42433.1 - 0.86 9.8 9.3 0.32 11.1 4.6 2.4 2 0 0 2 2 2 0 FYVE zinc finger zf-C4pol PF14260.6 EDP42433.1 - 3.7 8.1 8.9 2.2 8.8 0.5 2.8 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DEAD PF00270.29 EDP42434.1 - 1.2e-35 122.9 0.0 2.8e-35 121.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42434.1 - 6.3e-29 100.6 0.0 2.3e-26 92.3 0.1 2.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42434.1 - 9.4e-09 35.5 0.0 1.7e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDP42434.1 - 0.036 13.4 0.0 0.066 12.5 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Methyltransf_25 PF13649.6 EDP42435.1 - 0.06 14.1 0.0 0.14 12.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain G-patch_2 PF12656.7 EDP42436.1 - 4.4e-24 84.3 0.8 9.8e-24 83.2 0.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 EDP42436.1 - 4.4e-05 23.3 4.5 0.00014 21.7 4.4 2.0 1 1 0 1 1 1 1 G-patch domain Asp PF00026.23 EDP42437.1 - 1.3e-105 353.3 0.0 1.6e-105 353.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDP42437.1 - 7.8e-15 55.6 0.4 1.6e-12 48.0 0.4 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDP42437.1 - 1.4e-05 24.9 0.0 0.00021 21.1 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EDP42437.1 - 0.00037 21.1 0.0 0.3 11.7 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP42437.1 - 0.0053 17.3 0.0 3.3 8.3 0.0 2.7 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease BUD22 PF09073.10 EDP42438.1 - 0.14 11.4 47.4 0.38 10.1 31.1 2.2 2 0 0 2 2 2 0 BUD22 Utp14 PF04615.13 EDP42438.1 - 0.69 8.4 37.4 0.032 12.8 24.6 2.1 2 0 0 2 2 2 0 Utp14 protein SOG2 PF10428.9 EDP42438.1 - 2.7 7.1 56.0 0.65 9.1 42.0 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein MAD PF05557.13 EDP42440.1 - 7.7e-40 136.9 52.9 1.6e-37 129.3 52.9 2.9 1 1 0 1 1 1 1 Mitotic checkpoint protein GAS PF13851.6 EDP42440.1 - 0.0046 16.3 3.4 0.0046 16.3 3.4 6.0 3 3 3 6 6 6 2 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 EDP42440.1 - 0.013 15.6 9.5 0.013 15.6 9.5 5.7 2 2 4 6 6 6 0 Tropomyosin like DUF4677 PF15726.5 EDP42440.1 - 0.072 13.2 0.6 3.4 7.8 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4677) Neuropep_like PF15161.6 EDP42440.1 - 0.12 12.0 6.8 11 5.8 0.0 5.4 4 1 1 5 5 5 0 Neuropeptide-like NPV_P10 PF05531.12 EDP42440.1 - 0.47 11.0 18.0 6.5 7.3 0.0 6.0 5 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein FAA_hydro_N_2 PF18288.1 EDP42440.1 - 1.5 9.3 9.5 0.78 10.2 0.1 4.1 3 1 1 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 Spc7 PF08317.11 EDP42440.1 - 2.4 7.0 61.1 0.37 9.6 12.8 5.4 3 2 2 5 5 5 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EDP42440.1 - 2.5 8.2 42.0 21 5.3 0.2 8.5 8 1 1 9 9 9 0 bZIP transcription factor Prefoldin_2 PF01920.20 EDP42440.1 - 3.1 7.8 42.0 0.43 10.6 2.1 7.8 6 1 2 8 8 8 0 Prefoldin subunit TSC22 PF01166.18 EDP42440.1 - 3.7 7.9 30.6 0.84 10.0 0.2 8.2 8 1 1 9 9 9 0 TSC-22/dip/bun family bZIP_1 PF00170.21 EDP42441.1 - 1.2e-05 25.3 10.0 5.8e-05 23.1 9.9 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDP42441.1 - 0.00014 21.8 9.3 0.00025 21.0 9.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper T3SS_needle_E PF08988.10 EDP42441.1 - 0.013 15.7 1.3 0.03 14.5 1.3 1.6 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle CREPT PF16566.5 EDP42441.1 - 0.016 15.4 3.8 0.03 14.5 3.8 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour SNAPc19 PF15497.6 EDP42441.1 - 0.07 13.6 0.7 0.07 13.6 0.7 2.4 3 0 0 3 3 3 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 bZIP_Maf PF03131.17 EDP42441.1 - 0.088 13.3 7.5 0.16 12.5 7.5 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF641 PF04859.12 EDP42441.1 - 0.5 10.7 4.2 3.6 7.9 3.2 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Transformer PF06495.11 EDP42441.1 - 0.71 9.9 8.4 1.6 8.8 8.4 1.6 1 0 0 1 1 1 0 Fruit fly transformer protein Sec2p PF06428.11 EDP42441.1 - 0.84 9.6 6.3 2.3 8.2 6.3 1.8 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p TBCA PF02970.16 EDP42442.1 - 1e-25 89.9 0.1 1.3e-25 89.5 0.1 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A PMEI PF04043.15 EDP42442.1 - 0.0034 17.7 1.4 0.0043 17.4 1.4 1.3 1 0 0 1 1 1 1 Plant invertase/pectin methylesterase inhibitor DUF2353 PF09789.9 EDP42442.1 - 0.024 14.0 0.5 0.027 13.8 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) HIP1_clath_bdg PF16515.5 EDP42442.1 - 0.22 12.2 3.2 1 10.0 0.7 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Pkinase PF00069.25 EDP42444.1 - 8.6e-29 100.7 0.1 1.3e-28 100.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42444.1 - 1.7e-14 53.7 0.5 3e-14 52.9 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP42444.1 - 0.00011 21.2 0.2 0.00016 20.6 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EDP42444.1 - 0.0025 16.9 0.2 0.0025 16.9 0.2 1.7 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase APH PF01636.23 EDP42444.1 - 0.0084 16.1 1.2 0.23 11.4 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDP42444.1 - 0.13 11.9 4.2 0.87 9.2 0.0 2.7 3 0 0 3 3 3 0 RIO1 family DEAD PF00270.29 EDP42445.1 - 1.5e-50 171.4 0.0 3.8e-50 170.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42445.1 - 3.9e-30 104.4 0.0 1.2e-28 99.6 0.0 2.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42445.1 - 6.9e-07 29.4 0.0 1.8e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EDP42445.1 - 0.0053 16.5 0.0 0.32 10.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDP42445.1 - 0.027 14.8 0.0 6.4 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Exo_endo_phos PF03372.23 EDP42446.1 - 0.09 12.3 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 EDP42447.1 - 6.7e-09 35.6 0.1 1e-08 35.0 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EDP42447.1 - 0.0023 17.8 0.1 0.82 9.5 0.0 2.8 3 0 0 3 3 3 2 Endonuclease-reverse transcriptase Peptidase_M22 PF00814.25 EDP42448.1 - 1.6e-47 162.5 0.0 1.9e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family zf-RING_5 PF14634.6 EDP42449.1 - 8.9e-05 22.4 1.3 0.00018 21.4 1.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EDP42449.1 - 0.026 14.8 0.8 0.026 14.8 0.8 1.8 1 1 0 1 1 1 0 Ring finger domain Ribosomal_L30 PF00327.20 EDP42450.1 - 1.7e-12 47.0 0.1 2.4e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e UbiA PF01040.18 EDP42451.1 - 1.2e-37 129.5 16.4 5.3e-37 127.5 16.4 1.8 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF1214 PF06742.11 EDP42452.1 - 1.4e-08 35.1 2.3 0.0002 21.7 0.1 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1214) Cyclin_N PF00134.23 EDP42453.1 - 8.7e-10 38.4 0.2 1.4e-09 37.7 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDP42453.1 - 1.3e-07 32.1 0.1 1.3e-07 32.1 0.1 1.8 2 1 0 2 2 2 1 Cyclin Hormone_3 PF00159.18 EDP42453.1 - 0.056 13.5 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 Pancreatic hormone peptide ABC_membrane PF00664.23 EDP42454.1 - 5.1e-18 65.7 0.1 6.1e-18 65.5 0.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDP42455.1 - 9.1e-58 194.7 0.0 1.2e-27 97.1 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDP42455.1 - 4.5e-21 75.7 1.3 8.4e-21 74.8 0.3 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EDP42455.1 - 1.8e-12 47.2 0.4 0.0028 17.2 0.0 4.4 4 1 1 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDP42455.1 - 1.6e-08 35.1 2.6 0.0084 16.5 0.5 3.4 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EDP42455.1 - 3.5e-08 33.1 0.0 0.011 15.5 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDP42455.1 - 1.9e-07 31.2 0.1 0.3 10.9 0.1 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EDP42455.1 - 7.7e-07 29.2 0.1 0.069 13.2 0.0 3.8 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDP42455.1 - 8.3e-07 29.3 0.3 0.015 15.5 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EDP42455.1 - 2.1e-05 24.9 1.4 0.13 12.5 0.1 3.2 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 EDP42455.1 - 8.1e-05 22.8 0.0 0.35 11.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EDP42455.1 - 0.00011 21.9 0.8 0.33 10.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EDP42455.1 - 0.00019 22.0 0.0 0.15 12.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EDP42455.1 - 0.00042 20.5 0.0 0.12 12.5 0.0 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain ABC_ATPase PF09818.9 EDP42455.1 - 0.00061 18.7 0.1 0.08 11.7 0.0 2.5 2 0 0 2 2 2 1 Predicted ATPase of the ABC class G-alpha PF00503.20 EDP42455.1 - 0.00094 18.4 0.0 0.13 11.4 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit RsgA_GTPase PF03193.16 EDP42455.1 - 0.00098 19.1 0.0 0.69 9.8 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase ATP-synt_ab PF00006.25 EDP42455.1 - 0.0014 18.3 1.0 0.25 11.0 0.0 2.7 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 EDP42455.1 - 0.0019 17.5 0.0 1 8.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin CbiA PF01656.23 EDP42455.1 - 0.0054 16.8 0.5 0.3 11.1 0.0 3.0 3 1 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 EDP42455.1 - 0.0067 16.8 0.1 7.1 7.1 0.0 2.9 3 0 0 3 3 2 0 RNA helicase DUF3987 PF13148.6 EDP42455.1 - 0.01 14.9 0.0 2.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_24 PF13479.6 EDP42455.1 - 0.011 15.4 0.0 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EDP42455.1 - 0.013 14.9 0.3 0.5 9.7 0.0 2.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family APS_kinase PF01583.20 EDP42455.1 - 0.025 14.5 0.1 3.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_7 PF12775.7 EDP42455.1 - 0.027 14.0 0.0 9.1 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 EDP42455.1 - 0.036 13.8 0.0 8.5 6.1 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Ploopntkinase3 PF18751.1 EDP42455.1 - 0.039 13.9 0.1 2.9 7.7 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 EDP42455.1 - 0.039 14.4 0.2 21 5.6 0.0 3.4 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDP42455.1 - 0.044 13.5 18.6 0.02 14.6 1.7 5.0 5 1 0 5 5 5 0 AAA domain MMR_HSR1 PF01926.23 EDP42455.1 - 0.048 13.7 0.0 2.6 8.1 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EDP42455.1 - 0.054 12.7 0.0 4 6.5 0.0 2.4 2 1 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 EDP42455.1 - 0.054 13.4 0.1 15 5.4 0.0 2.7 3 0 0 3 3 2 0 NACHT domain AAA_17 PF13207.6 EDP42455.1 - 0.056 13.9 0.1 6.5 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDP42455.1 - 0.069 12.5 0.0 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Ploopntkinase1 PF18748.1 EDP42455.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 AAA_15 PF13175.6 EDP42455.1 - 0.15 11.7 0.0 16 5.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EDP42455.1 - 0.23 11.9 0.0 11 6.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain HSP70 PF00012.20 EDP42456.1 - 9.6e-07 27.4 2.2 1.1e-06 27.2 2.2 1.0 1 0 0 1 1 1 1 Hsp70 protein ATP-synt_DE PF00401.20 EDP42456.1 - 0.56 10.5 10.6 0.26 11.6 6.3 2.3 2 1 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain HSP70 PF00012.20 EDP42457.1 - 4.8e-120 401.5 0.8 5.8e-120 401.3 0.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDP42457.1 - 3.5e-14 52.4 0.1 4.8e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EDP42457.1 - 0.01 15.1 0.2 0.015 14.6 0.2 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.11 EDP42457.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 0 StbA protein DDR PF08841.10 EDP42457.1 - 0.032 13.2 1.6 0.069 12.1 0.1 2.1 2 1 1 3 3 3 0 Diol dehydratase reactivase ATPase-like domain Ribosomal_S2 PF00318.20 EDP42458.1 - 1.6e-52 177.9 0.0 4.1e-52 176.5 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein S2 DUF5542 PF17696.1 EDP42458.1 - 0.09 12.9 0.3 0.24 11.5 0.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5542) SR-25 PF10500.9 EDP42458.1 - 0.83 9.2 18.7 0.91 9.1 15.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SNF5 PF04855.12 EDP42459.1 - 1.9e-58 198.1 0.1 2.7e-58 197.6 0.1 1.2 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EDP42459.1 - 0.0056 16.3 1.5 0.0056 16.3 1.5 2.1 2 0 0 2 2 2 1 GATA zinc finger PITH PF06201.13 EDP42460.1 - 1.5e-25 90.2 0.0 1.8e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain TrkH PF02386.16 EDP42461.1 - 7.9e-96 321.5 8.2 1.9e-93 313.6 5.2 2.1 2 0 0 2 2 2 2 Cation transport protein UPF0016 PF01169.19 EDP42462.1 - 2.5e-21 75.8 15.0 8.4e-18 64.5 7.2 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Trp_oprn_chp PF09534.10 EDP42462.1 - 0.00027 20.8 0.2 0.016 15.0 0.0 2.2 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3995 PF13160.6 EDP42462.1 - 0.0071 16.7 5.7 0.4 11.0 2.2 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3995) DUF4131 PF13567.6 EDP42462.1 - 0.021 14.5 0.5 1.3 8.7 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) O-antigen_lig PF13425.6 EDP42462.1 - 0.14 10.9 0.2 1.2 7.9 0.5 1.9 2 0 0 2 2 2 0 O-antigen ligase like membrane protein PCMT PF01135.19 EDP42462.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FAM70 PF14967.6 EDP42462.1 - 3 7.2 8.0 0.29 10.5 0.2 2.1 2 0 0 2 2 2 0 FAM70 protein DUF485 PF04341.12 EDP42462.1 - 6.6 6.8 8.4 0.95 9.5 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Sad1_UNC PF07738.13 EDP42463.1 - 2.1e-24 86.0 0.0 4.2e-24 85.0 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Lectin_N PF03954.14 EDP42463.1 - 0.046 13.5 3.5 0.16 11.7 3.1 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Cellulase PF00150.18 EDP42464.1 - 7.3e-16 58.4 1.1 7.3e-16 58.4 1.1 1.6 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) GSCFA PF08885.11 EDP42464.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 GSCFA family RhoGEF PF00621.20 EDP42465.1 - 2.1e-28 99.8 0.0 2.8e-27 96.1 0.0 2.3 1 1 0 1 1 1 1 RhoGEF domain T3SSipB PF16535.5 EDP42465.1 - 0.12 12.9 0.2 0.45 11.0 0.0 1.9 2 0 0 2 2 2 0 Type III cell invasion protein SipB Hexapep PF00132.24 EDP42467.1 - 6.3e-10 38.4 4.0 6.1e-06 25.8 2.6 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EDP42467.1 - 7.8e-06 25.5 2.2 7.5e-05 22.4 0.6 2.2 1 1 1 2 2 2 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EDP42467.1 - 0.0024 16.9 0.0 0.0026 16.8 0.0 1.0 1 0 0 1 1 1 1 L-fucokinase NAPRTase PF04095.16 EDP42468.1 - 2e-51 174.9 0.0 2.9e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family EF-hand_6 PF13405.6 EDP42469.1 - 3e-07 29.8 0.1 0.0054 16.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EDP42469.1 - 9.3e-07 29.2 0.3 0.0037 17.7 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EDP42469.1 - 0.0006 19.2 0.6 0.37 10.4 0.0 2.5 2 0 0 2 2 2 2 EF hand DUF2666 PF10869.8 EDP42469.1 - 0.0045 17.2 0.1 0.58 10.4 0.0 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF2666) EF-hand_9 PF14658.6 EDP42469.1 - 0.02 15.2 0.0 8.1 6.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 EDP42469.1 - 0.1 12.1 0.6 0.39 10.3 0.0 2.1 2 0 0 2 2 2 0 EF hand TAS2R PF05296.13 EDP42470.1 - 0.16 11.1 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) UPF0220 PF05255.11 EDP42471.1 - 4.4e-64 215.0 0.0 5e-64 214.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Myb_DNA-binding PF00249.31 EDP42472.1 - 2.7e-23 81.9 2.0 1.3e-11 44.5 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP42472.1 - 5.8e-22 77.7 4.3 4.8e-14 52.3 1.6 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EDP42472.1 - 0.036 14.1 0.1 7.4 6.6 0.0 2.3 1 1 1 2 2 2 0 SLIDE HTH_AsnC-type PF13404.6 EDP42472.1 - 0.066 13.0 0.3 0.41 10.5 0.0 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Myb_Cef PF11831.8 EDP42473.1 - 1.2e-44 152.7 7.2 2.9e-44 151.4 7.2 1.6 1 0 0 1 1 1 1 pre-mRNA splicing factor component Aminotran_1_2 PF00155.21 EDP42474.1 - 3.4e-59 200.8 0.0 4.3e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDP42474.1 - 0.11 11.0 0.0 0.39 9.2 0.0 1.7 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Med17 PF10156.9 EDP42475.1 - 7e-09 34.9 0.0 6.3e-08 31.8 0.0 2.1 1 1 0 1 1 1 1 Subunit 17 of Mediator complex DAOA PF15199.6 EDP42475.1 - 0.064 13.7 0.2 0.18 12.2 0.2 1.7 1 0 0 1 1 1 0 D-amino acid oxidase activator FKBP_C PF00254.28 EDP42476.1 - 2.6e-34 117.4 0.0 3.3e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LSM PF01423.22 EDP42477.1 - 3.5e-13 49.0 0.0 4.3e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain zf-CCCH_2 PF14608.6 EDP42478.1 - 7.4e-13 48.4 37.3 5.8e-05 23.4 2.3 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger TFIIA PF03153.13 EDP42478.1 - 0.036 14.1 4.5 0.051 13.6 4.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MerC PF03203.14 EDP42479.1 - 0.82 10.1 7.2 0.23 11.9 1.0 2.7 3 0 0 3 3 3 0 MerC mercury resistance protein PseudoU_synth_2 PF00849.22 EDP42480.1 - 1.7e-21 76.9 0.0 3.5e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase Sld7_C PF18596.1 EDP42481.1 - 0.015 15.4 0.1 0.03 14.4 0.1 1.5 1 0 0 1 1 1 0 Sld7 C-terminal domain MMR_HSR1 PF01926.23 EDP42482.1 - 7.1e-12 45.4 0.0 1.4e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 EDP42482.1 - 0.0035 16.4 0.0 0.0061 15.7 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 EDP42482.1 - 0.017 14.7 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EDP42482.1 - 0.091 12.8 0.3 0.42 10.7 0.1 2.1 3 0 0 3 3 3 0 Dynamin family Roc PF08477.13 EDP42482.1 - 0.12 12.6 0.3 1.9 8.8 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EDP42482.1 - 0.14 11.9 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDP42482.1 - 0.16 11.8 0.5 1.3 8.9 0.2 2.3 2 1 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 EDP42482.1 - 0.28 11.7 0.0 0.45 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDP42482.1 - 0.29 11.5 1.5 0.44 10.9 0.1 2.1 3 0 0 3 3 3 0 AAA ATPase domain GvpG PF05120.12 EDP42483.1 - 0.22 11.6 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Gas vesicle protein G GREB1 PF15782.5 EDP42483.1 - 9.3 3.2 24.4 13 2.7 24.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MIF4G PF02854.19 EDP42485.1 - 1.3e-55 188.4 0.3 1.3e-55 188.4 0.3 1.6 2 0 0 2 2 2 1 MIF4G domain eIF_4G1 PF12152.8 EDP42485.1 - 6.8e-20 71.0 0.5 1.7e-19 69.7 0.5 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 MA3 PF02847.17 EDP42485.1 - 8.3e-11 41.9 0.5 1.8e-09 37.6 0.1 2.4 2 0 0 2 2 2 1 MA3 domain Bromodomain PF00439.25 EDP42487.1 - 5.3e-10 39.2 0.0 9.5e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Bromodomain tRNA-synt_2 PF00152.20 EDP42488.1 - 7.6e-87 291.3 0.0 1.1e-86 290.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDP42488.1 - 2.1e-10 40.4 0.0 4.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4539 PF15072.6 EDP42488.1 - 0.048 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) CPSF100_C PF13299.6 EDP42488.1 - 0.15 12.2 0.8 7.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S8 PF00082.22 EDP42489.1 - 6.7e-33 114.2 7.0 1.2e-32 113.3 7.0 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EDP42489.1 - 3.1e-06 27.7 0.0 1.7e-05 25.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase inhibitor I9 Pkinase PF00069.25 EDP42490.1 - 4.3e-70 236.1 0.0 5.4e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42490.1 - 2.3e-34 118.8 0.0 3.1e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDP42490.1 - 0.0042 16.5 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP42490.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP42490.1 - 0.018 14.0 0.6 0.049 12.6 0.1 1.7 1 1 1 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 EDP42490.1 - 0.022 14.4 1.2 4.8 6.7 0.0 2.4 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDP42490.1 - 0.06 12.9 0.2 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 EDP42490.1 - 0.062 12.1 0.2 0.36 9.6 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Spt20 PF12090.8 EDP42490.1 - 0.23 11.0 4.8 0.34 10.5 4.8 1.2 1 0 0 1 1 1 0 Spt20 family GIT_SHD PF08518.11 EDP42491.1 - 3.6e-19 68.1 21.9 3.5e-12 45.7 2.6 3.4 4 0 0 4 4 4 2 Spa2 homology domain (SHD) of GIT PspB PF06667.12 EDP42491.1 - 4.4 7.4 6.0 14 5.9 1.5 3.3 2 0 0 2 2 2 0 Phage shock protein B Mito_carr PF00153.27 EDP42492.1 - 3.2e-67 222.5 1.5 2.5e-21 75.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EDP42493.1 - 9.5e-26 89.4 0.0 1.1e-06 28.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP42493.1 - 2.5e-12 46.5 0.0 0.015 15.1 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif DUF4523 PF15023.6 EDP42493.1 - 0.00041 20.2 0.0 1.6 8.5 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 EDP42493.1 - 0.13 12.4 0.0 9.1 6.5 0.0 3.3 4 0 0 4 4 4 0 RNA recognition motif ER_lumen_recept PF00810.18 EDP42494.1 - 1.3e-41 142.8 11.3 1.7e-41 142.5 11.3 1.1 1 0 0 1 1 1 1 ER lumen protein retaining receptor NMO PF03060.15 EDP42495.1 - 5.4e-48 164.1 4.8 2.3e-46 158.7 4.8 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EDP42495.1 - 8.5e-10 38.2 1.3 0.00037 19.6 0.3 2.2 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Zip PF02535.22 EDP42496.1 - 2e-21 76.6 13.1 1.9e-14 53.7 11.3 2.3 1 1 0 2 2 2 2 ZIP Zinc transporter BCLP PF12304.8 EDP42496.1 - 0.074 12.6 2.0 0.17 11.5 2.0 1.6 1 0 0 1 1 1 0 Beta-casein like protein LRR_4 PF12799.7 EDP42497.1 - 1.3e-07 31.8 5.6 5.6e-05 23.4 0.3 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP42497.1 - 1.5e-07 31.1 1.7 3.5e-07 29.9 1.7 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 EDP42497.1 - 0.0067 16.8 2.0 9.4 7.2 0.0 4.6 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 EDP42497.1 - 1.2 9.4 2.8 2 8.7 0.0 2.7 3 0 0 3 3 3 0 Leucine Rich repeat TFIID_30kDa PF03540.13 EDP42498.1 - 1e-25 89.4 0.0 1.9e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CBS PF00571.28 EDP42498.1 - 0.012 16.0 0.3 1.5 9.3 0.0 3.0 3 0 0 3 3 3 0 CBS domain bZIP_1 PF00170.21 EDP42499.1 - 7.1e-06 26.0 6.7 2.8e-05 24.1 4.3 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EDP42499.1 - 0.073 13.6 1.2 1.4 9.5 0.1 2.5 2 0 0 2 2 2 0 bZIP Maf transcription factor TolA_bind_tri PF16331.5 EDP42499.1 - 0.29 11.2 3.2 0.18 11.9 0.2 2.0 2 0 0 2 2 2 0 TolA binding protein trimerisation bZIP_2 PF07716.15 EDP42499.1 - 1.5 9.0 9.7 0.72 10.0 3.7 2.3 2 0 0 2 2 2 0 Basic region leucine zipper SMC_N PF02463.19 EDP42501.1 - 1.4e-64 217.6 0.0 2.3e-64 216.9 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDP42501.1 - 1.1e-28 99.9 0.0 2.9e-28 98.5 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDP42501.1 - 7.5e-14 52.2 0.4 8.9e-06 25.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDP42501.1 - 2.2e-13 50.7 0.2 5.4e-08 33.0 0.0 3.3 3 2 0 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 EDP42501.1 - 5e-12 46.7 27.2 5e-12 46.7 27.2 5.3 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDP42501.1 - 0.025 14.3 0.0 0.062 13.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1617 PF07761.12 EDP42501.1 - 0.077 13.1 2.7 0.26 11.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1617) eIF3g PF12353.8 EDP42501.1 - 0.83 10.1 4.8 0.37 11.2 0.4 2.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G EMC3_TMCO1 PF01956.16 EDP42502.1 - 7.5e-33 113.7 0.4 9.2e-33 113.4 0.4 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Ceramidase PF05875.12 EDP42503.1 - 7e-58 196.1 9.5 8.4e-58 195.9 9.5 1.0 1 0 0 1 1 1 1 Ceramidase Pinin_SDK_memA PF04696.13 EDP42504.1 - 8.7e-08 32.3 24.1 1.3e-07 31.8 10.2 3.2 2 2 1 3 3 3 2 pinin/SDK/memA/ protein conserved region Sporozoite_P67 PF05642.11 EDP42504.1 - 0.28 9.2 1.2 0.49 8.4 1.2 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen KfrA_N PF11740.8 EDP42504.1 - 0.68 10.6 19.7 2.5 8.8 2.9 2.5 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term EPL1 PF10513.9 EDP42504.1 - 1.2 9.5 9.5 2.5 8.4 9.5 1.5 1 1 0 1 1 1 0 Enhancer of polycomb-like PhoLip_ATPase_C PF16212.5 EDP42505.1 - 1.6e-73 247.5 23.5 1.6e-73 247.5 23.5 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EDP42505.1 - 2.7e-24 84.6 1.3 2.7e-24 84.6 1.3 1.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EDP42505.1 - 4.3e-11 43.5 3.7 9.1e-07 29.4 1.5 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDP42505.1 - 4.7e-11 42.6 0.0 2.4e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDP42505.1 - 0.026 14.3 0.1 0.083 12.6 0.1 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDP42505.1 - 0.1 13.0 0.1 1.6 9.1 0.1 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TMEM223 PF14640.6 EDP42506.1 - 0.0075 16.5 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 Transmembrane protein 223 TMEM238 PF15125.6 EDP42506.1 - 0.19 12.0 7.8 0.34 11.1 1.2 2.2 2 0 0 2 2 2 0 TMEM238 protein family RNase_T PF00929.24 EDP42507.1 - 1.7e-12 48.2 0.0 3.6e-12 47.1 0.0 1.6 2 0 0 2 2 2 1 Exonuclease RabGAP-TBC PF00566.18 EDP42508.1 - 2.6e-52 177.6 0.0 3.5e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IL34 PF15036.6 EDP42508.1 - 0.17 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Interleukin 34 RNA_pol_Rpb8 PF03870.15 EDP42509.1 - 3.8e-47 160.0 0.1 4.3e-47 159.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EDP42509.1 - 0.12 12.5 0.1 1.8 8.6 0.1 2.0 1 1 1 2 2 2 0 DNA-directed RNA polymerase, subunit G polyprenyl_synt PF00348.17 EDP42510.1 - 4.4e-33 114.4 0.0 5.4e-33 114.1 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase DUF1409 PF07197.12 EDP42510.1 - 0.035 14.0 0.0 0.088 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) FGGY_C PF02782.16 EDP42511.1 - 9.6e-14 51.6 0.0 3e-13 50.0 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDP42511.1 - 3e-07 30.3 0.6 8.2e-06 25.6 0.1 2.5 1 1 1 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain Chon_Sulph_att PF06566.11 EDP42511.1 - 0.05 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Chondroitin sulphate attachment domain GSu_C4xC__C2xCH PF09698.10 EDP42511.1 - 2.1 9.2 5.3 7.1 7.5 0.1 3.7 4 0 0 4 4 4 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) HEAT_EZ PF13513.6 EDP42512.1 - 1.4e-27 95.7 20.9 2.8e-14 53.2 0.1 9.8 7 2 3 10 10 10 4 HEAT-like repeat HEAT_2 PF13646.6 EDP42512.1 - 2.7e-17 63.0 1.8 6.9e-05 23.2 0.0 7.0 5 3 3 8 8 8 4 HEAT repeats HEAT PF02985.22 EDP42512.1 - 8.3e-17 59.9 18.8 0.00077 19.5 0.0 9.0 9 0 0 9 9 7 4 HEAT repeat Vac14_Fab1_bd PF12755.7 EDP42512.1 - 3.6e-11 43.5 0.0 0.0018 18.9 0.0 5.1 4 2 1 5 5 5 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EDP42512.1 - 1.5e-05 25.1 0.0 0.16 12.0 0.0 3.7 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EDP42512.1 - 0.0002 21.2 0.0 0.00088 19.2 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain MMS19_C PF12460.8 EDP42512.1 - 0.0016 17.6 8.5 0.083 12.0 0.1 4.1 3 1 2 5 5 5 2 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 EDP42512.1 - 0.0062 16.7 0.7 0.3 11.3 0.0 3.9 5 0 0 5 5 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3437 PF11919.8 EDP42512.1 - 0.029 14.3 1.1 4.1 7.4 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3437) MFAP1 PF06991.11 EDP42512.1 - 0.042 13.7 2.7 0.071 12.9 2.7 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing eIF3_N PF09440.10 EDP42512.1 - 0.15 12.5 0.1 0.38 11.2 0.1 1.7 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain TFIIA PF03153.13 EDP42512.1 - 0.27 11.2 7.3 0.43 10.5 7.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arm PF00514.23 EDP42512.1 - 0.29 11.3 11.0 2.2 8.5 0.1 6.5 8 0 0 8 8 7 0 Armadillo/beta-catenin-like repeat CAF1A PF12253.8 EDP42512.1 - 1.2 9.4 10.9 2.4 8.4 10.9 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Sigma70_ner PF04546.13 EDP42512.1 - 1.3 8.8 5.0 1.4e+02 2.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region RNA_pol_3_Rpc31 PF11705.8 EDP42512.1 - 3.8 7.7 11.8 7.5 6.7 11.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.12 EDP42512.1 - 5.9 6.2 8.8 9.3 5.6 8.8 1.2 1 0 0 1 1 1 0 SDA1 DUF3437 PF11919.8 EDP42513.1 - 0.0041 17.0 0.0 0.0043 16.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) Cpn60_TCP1 PF00118.24 EDP42514.1 - 1.6e-122 409.6 0.2 2.2e-63 214.6 0.0 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family TetR_C_14 PF17754.1 EDP42514.1 - 0.012 15.6 0.1 0.031 14.2 0.1 1.7 1 0 0 1 1 1 0 MftR C-terminal domain Sacchrp_dh_NADP PF03435.18 EDP42515.1 - 4.6e-14 52.8 0.3 1e-13 51.7 0.3 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EDP42515.1 - 0.0008 19.3 0.8 0.0014 18.6 0.8 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EDP42515.1 - 0.0029 18.0 0.2 0.019 15.4 0.2 2.2 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EDP42515.1 - 0.012 15.2 1.0 0.019 14.5 1.0 1.3 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 EDP42515.1 - 0.17 11.2 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase UPF0086 PF01868.16 EDP42516.1 - 1.6e-15 56.7 0.0 6.4e-14 51.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function UPF0086 RCC1 PF00415.18 EDP42517.1 - 3.3e-31 107.7 10.9 3.2e-09 37.3 0.1 5.8 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 EDP42517.1 - 3.2e-12 46.2 4.4 3.2e-12 46.2 4.4 2.2 3 0 0 3 3 2 1 PHD-finger RCC1_2 PF13540.6 EDP42517.1 - 1.1e-11 44.2 24.7 0.00014 21.6 0.7 5.3 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Prok-RING_1 PF14446.6 EDP42517.1 - 0.022 14.7 2.3 0.022 14.7 2.3 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 EDP42517.1 - 0.041 14.2 0.2 0.041 14.2 0.2 2.3 3 0 0 3 3 2 0 C1 domain PHD_2 PF13831.6 EDP42517.1 - 0.05 13.2 0.7 0.05 13.2 0.7 2.2 2 0 0 2 2 2 0 PHD-finger zf-PHD-like PF15446.6 EDP42517.1 - 0.054 13.1 0.2 0.11 12.2 0.2 1.5 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FANCL_C PF11793.8 EDP42517.1 - 0.085 13.0 0.3 0.26 11.5 0.3 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain Reg_prop PF07494.11 EDP42517.1 - 0.14 12.5 0.2 6.6 7.3 0.2 3.2 3 0 0 3 3 3 0 Two component regulator propeller PHD_4 PF16866.5 EDP42517.1 - 1.4 9.0 10.7 0.34 11.1 6.1 2.4 2 1 0 2 2 2 0 PHD-finger zf-piccolo PF05715.13 EDP42517.1 - 3.3 7.9 7.1 1.6 9.0 3.5 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger E1-E2_ATPase PF00122.20 EDP42518.1 - 6.7e-50 169.1 0.5 6.7e-50 169.1 0.5 3.6 5 0 0 5 5 5 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDP42518.1 - 1.1e-35 123.0 3.6 2.9e-35 121.6 3.6 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDP42518.1 - 1.4e-25 90.9 0.7 4.1e-25 89.3 0.5 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDP42518.1 - 1.9e-14 53.1 0.0 5.2e-14 51.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EDP42518.1 - 1.2e-12 47.8 0.0 2.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDP42518.1 - 1.9e-07 31.1 1.4 1.9e-05 24.5 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDP42518.1 - 0.031 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HSP70 PF00012.20 EDP42519.1 - 3.2e-46 157.8 3.0 4.8e-45 153.9 3.0 2.3 1 1 0 1 1 1 1 Hsp70 protein Menin PF05053.13 EDP42519.1 - 0.67 8.2 13.5 1 7.6 13.5 1.2 1 0 0 1 1 1 0 Menin DUF4719 PF15843.5 EDP42519.1 - 1.6 8.8 5.1 3.1 7.8 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Sel1 PF08238.12 EDP42521.1 - 7.8e-12 45.5 13.4 0.023 15.4 0.2 6.5 6 0 0 6 6 6 6 Sel1 repeat TPR_2 PF07719.17 EDP42522.1 - 0.18 12.0 1.7 21 5.5 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 EDP42523.1 - 5.3e-11 42.8 9.0 0.00023 21.7 0.1 5.9 6 0 0 6 6 6 2 Sel1 repeat DRIM PF07539.12 EDP42524.1 - 5.4e-149 497.4 3.8 5.4e-149 497.4 3.8 2.8 3 1 1 4 4 4 1 Down-regulated in metastasis Kri1_C PF12936.7 EDP42525.1 - 1.7e-24 85.8 0.0 1.7e-24 85.8 0.0 4.2 3 1 1 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 EDP42525.1 - 7.4e-24 84.3 10.9 7.4e-24 84.3 10.9 4.5 4 2 0 4 4 4 1 KRI1-like family LIN52 PF10044.9 EDP42525.1 - 0.041 14.6 8.5 2.8 8.7 0.1 3.0 2 1 0 2 2 2 0 Retinal tissue protein SQS_PSY PF00494.19 EDP42526.1 - 3.6e-30 105.4 0.0 5.4e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Med15_fungi PF05397.12 EDP42528.1 - 6e-25 87.7 3.0 6e-25 87.7 3.0 3.9 3 0 0 3 3 3 1 Mediator complex subunit 15 ARID PF01388.21 EDP42528.1 - 4.7e-17 62.4 3.1 1.3e-16 61.0 0.1 3.2 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain PspB PF06667.12 EDP42528.1 - 8.9 6.5 6.5 57 3.9 0.1 3.0 2 0 0 2 2 2 0 Phage shock protein B CCDC85 PF10226.9 EDP42529.1 - 0.00039 20.1 0.7 0.00053 19.7 0.7 1.2 1 0 0 1 1 1 1 CCDC85 family BRE1 PF08647.11 EDP42529.1 - 0.008 16.2 3.1 0.008 16.2 3.1 1.6 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase NUDE_C PF04880.13 EDP42529.1 - 0.068 13.7 4.1 0.049 14.1 2.7 1.4 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region YabA PF06156.13 EDP42529.1 - 0.1 13.2 1.0 0.24 12.1 1.0 1.7 1 1 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 EDP42529.1 - 0.23 11.3 6.3 0.22 11.3 4.3 1.9 2 0 0 2 2 2 0 Septum formation initiator bZIP_2 PF07716.15 EDP42529.1 - 0.84 9.8 8.0 1.7 8.8 6.3 2.2 1 1 1 2 2 2 0 Basic region leucine zipper ZapB PF06005.12 EDP42529.1 - 1.2 9.6 8.9 0.11 12.9 4.3 1.6 2 0 0 2 2 2 0 Cell division protein ZapB CASP_C PF08172.12 EDP42529.1 - 1.5 8.1 9.5 0.95 8.8 3.4 2.2 1 1 1 2 2 2 0 CASP C terminal NRBF2 PF08961.10 EDP42529.1 - 1.6 8.3 6.8 3.6 7.1 6.0 1.8 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator HAUS-augmin3 PF14932.6 EDP42529.1 - 1.8 8.0 6.8 3.3 7.2 6.7 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4337 PF14235.6 EDP42529.1 - 3 7.9 6.2 1 9.5 3.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) tRNA-synt_2b PF00587.25 EDP42530.1 - 1.3e-36 126.3 0.0 2.1e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDP42530.1 - 2.4e-19 69.2 0.2 4.4e-19 68.4 0.2 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EDP42530.1 - 3.3e-10 39.9 0.0 6.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EDP42530.1 - 1.3e-08 34.7 0.0 2.4e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 TGS domain PTPA PF03095.15 EDP42531.1 - 5e-70 236.3 0.0 6.2e-70 236.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein GatB_N PF02934.15 EDP42532.1 - 1.4e-70 237.8 0.0 2e-66 224.2 0.0 2.1 1 1 1 2 2 2 2 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EDP42532.1 - 8.2e-30 103.6 0.0 1.2e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 GatB domain SNAP PF14938.6 EDP42533.1 - 2.1e-94 316.1 6.5 2.3e-94 316.0 6.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Spatacsin_C PF14649.6 EDP42533.1 - 9.5e-06 24.9 4.8 0.001 18.3 0.6 2.2 1 1 1 2 2 2 2 Spatacsin C-terminus TPR_MalT PF17874.1 EDP42533.1 - 2.9e-05 23.6 5.8 4.4e-05 23.0 5.8 1.2 1 0 0 1 1 1 1 MalT-like TPR region Suppressor_APC PF11414.8 EDP42533.1 - 0.0096 16.0 0.2 0.027 14.6 0.2 1.8 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein TPR_1 PF00515.28 EDP42533.1 - 0.11 12.4 3.4 11 6.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat PmbA_TldD PF01523.16 EDP42533.1 - 3.6 7.3 5.5 5.2 6.8 5.0 1.5 1 1 1 2 2 2 0 Putative modulator of DNA gyrase Methyltransf_11 PF08241.12 EDP42534.1 - 8.9e-14 51.9 0.0 1.7e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP42534.1 - 1e-11 45.4 0.0 2.3e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP42534.1 - 2.1e-10 40.7 0.0 3.5e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP42534.1 - 8.5e-10 39.3 0.0 1.6e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42534.1 - 1.9e-05 24.5 0.0 3.8e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDP42534.1 - 2.8e-05 23.6 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Med5 PF08689.10 EDP42535.1 - 3.5e-06 25.2 1.1 7.8e-05 20.7 0.0 2.3 2 1 0 2 2 2 2 Mediator complex subunit Med5 PK PF00224.21 EDP42536.1 - 2.2e-151 503.6 0.4 2.9e-151 503.3 0.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EDP42536.1 - 5.6e-32 110.4 0.0 1.7e-31 108.9 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EDP42536.1 - 5.2e-06 25.8 0.9 2.5e-05 23.5 0.5 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EDP42536.1 - 0.0045 16.0 0.0 0.11 11.5 0.0 2.2 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain DUF3479 PF11965.8 EDP42536.1 - 0.086 13.0 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) IPPT PF01715.17 EDP42538.1 - 1.2e-53 182.3 0.0 3.7e-53 180.7 0.0 1.8 1 0 0 1 1 1 1 IPP transferase Peptidase_M1 PF01433.20 EDP42538.1 - 8.8e-40 136.6 0.0 1.4e-39 135.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EDP42538.1 - 9.4e-37 125.6 0.1 2.3e-36 124.3 0.1 1.7 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EDP42538.1 - 1.7e-24 87.1 0.1 2.9e-24 86.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain AAA_33 PF13671.6 EDP42538.1 - 0.0025 18.0 4.0 0.31 11.2 0.0 3.7 4 0 0 4 4 4 1 AAA domain IPT PF01745.16 EDP42538.1 - 0.0087 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Isopentenyl transferase AAA_16 PF13191.6 EDP42538.1 - 0.01 16.2 0.1 0.36 11.2 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 EDP42538.1 - 0.048 13.9 0.9 0.83 9.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EDP42538.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 EDP42538.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Autophagy_N PF03986.13 EDP42539.1 - 1.2e-37 128.9 0.1 2e-37 128.2 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EDP42539.1 - 3.2e-19 69.3 0.0 1.2e-18 67.4 0.0 2.1 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EDP42539.1 - 6.2e-12 44.8 1.2 1e-11 44.1 1.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Aconitase PF00330.20 EDP42540.1 - 3.9e-111 372.3 0.1 3.7e-110 369.1 0.1 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDP42540.1 - 3.7e-20 72.6 0.0 8.1e-20 71.5 0.0 1.6 1 1 0 1 1 1 1 Aconitase C-terminal domain IlvN PF07991.12 EDP42541.1 - 2.5e-44 150.7 0.0 3.7e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EDP42541.1 - 3.3e-40 137.7 0.0 7.7e-40 136.5 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain Rtt106_N PF18215.1 EDP42541.1 - 0.046 13.5 1.1 6.4 6.6 0.3 3.1 4 0 0 4 4 4 0 Histone chaperone Rtt106 N-terminal domain Metallophos PF00149.28 EDP42542.1 - 1.8e-10 41.7 0.1 2.3e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 EDP42542.1 - 0.0041 15.5 0.5 0.075 11.3 0.0 2.0 2 0 0 2 2 2 2 Firmicute fructose-1,6-bisphosphatase LSM PF01423.22 EDP42543.1 - 3.9e-20 71.3 0.0 4.4e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EDP42543.1 - 0.066 13.4 0.0 0.083 13.0 0.0 1.2 1 0 0 1 1 1 0 RimP C-terminal SH3 domain WSD PF15613.6 EDP42544.1 - 4.4e-23 81.6 2.4 4.7e-23 81.5 0.1 2.3 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EDP42544.1 - 2.9e-12 46.7 0.0 5.7e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EDP42544.1 - 0.0044 16.5 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 ING PF12998.7 EDP42544.1 - 2.5 8.7 5.8 0.65 10.6 1.2 2.2 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF5315 PF17242.2 EDP42544.1 - 2.6 7.9 9.6 0.15 11.9 0.9 2.6 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) Abhydrolase_1 PF00561.20 EDP42545.1 - 3.7e-15 56.3 0.0 2.7e-13 50.1 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP42545.1 - 6.4e-10 40.0 2.7 8.5e-10 39.6 2.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP42545.1 - 8.8e-10 38.3 0.9 1.8e-08 33.9 0.9 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EDP42545.1 - 0.00066 19.5 0.1 0.0018 18.1 0.1 1.6 1 1 1 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 EDP42545.1 - 0.00076 19.0 0.1 0.0011 18.5 0.1 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 EDP42545.1 - 0.001 18.9 0.0 0.64 9.8 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Palm_thioest PF02089.15 EDP42545.1 - 0.014 15.3 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Peptidase_S9 PF00326.21 EDP42545.1 - 0.029 13.9 0.1 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 EDP42545.1 - 0.037 13.7 0.0 0.22 11.1 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Agenet PF05641.12 EDP42546.1 - 0.0062 17.0 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 Agenet domain RR_TM4-6 PF06459.12 EDP42546.1 - 0.059 13.2 3.1 0.067 13.0 3.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L31e PF01198.19 EDP42547.1 - 2.9e-39 133.1 2.8 3.7e-39 132.8 2.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e GTP_EFTU PF00009.27 EDP42548.1 - 8.2e-58 195.1 0.4 1.4e-57 194.3 0.4 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDP42548.1 - 2e-29 102.1 0.0 4.2e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDP42548.1 - 5.9e-15 55.4 5.4 5.9e-15 55.4 5.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP42548.1 - 1.9e-05 24.7 0.3 5e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase cobW PF02492.19 EDP42548.1 - 0.0074 15.9 0.7 0.013 15.1 0.1 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDP42548.1 - 0.0075 16.2 0.2 0.023 14.6 0.1 1.7 1 1 1 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EDP42548.1 - 0.026 14.3 0.2 8.3 6.2 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EDP42548.1 - 0.12 12.9 0.2 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Spt5-NGN PF03439.13 EDP42549.1 - 1.1e-17 63.6 0.0 2.2e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 EDP42549.1 - 2.5e-17 63.7 14.1 2.5e-17 63.7 14.1 4.4 3 1 1 4 4 4 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 EDP42549.1 - 6.9e-12 45.8 49.6 3.4e-10 40.3 16.9 4.4 2 1 2 4 4 4 3 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 EDP42549.1 - 1e-06 28.5 14.3 0.017 15.1 0.2 6.0 6 0 0 6 6 6 3 KOW motif DNA_pol_phi PF04931.13 EDP42550.1 - 0.0037 15.5 42.8 0.0037 15.5 42.8 2.1 2 0 0 2 2 2 1 DNA polymerase phi SDA1 PF05285.12 EDP42550.1 - 7.2 5.9 48.8 0.025 14.0 22.9 2.4 2 0 0 2 2 2 0 SDA1 PP2C PF00481.21 EDP42551.1 - 3.8e-34 118.5 0.0 2.1e-31 109.5 0.0 2.6 2 1 0 2 2 2 2 Protein phosphatase 2C RRM_1 PF00076.22 EDP42552.1 - 5.1e-16 58.3 0.0 6.3e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP42552.1 - 3.7e-08 33.4 0.0 7.2e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif V-ATPase_C PF03223.15 EDP42553.1 - 6.1e-123 410.9 4.7 6.8e-123 410.7 4.7 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF1524 PF07510.11 EDP42553.1 - 0.064 13.1 0.2 0.18 11.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1524) HEAT_EZ PF13513.6 EDP42553.1 - 0.12 13.0 0.2 1.7 9.2 0.1 2.5 2 0 0 2 2 2 0 HEAT-like repeat PTS_2-RNA PF01885.16 EDP42554.1 - 1.2e-45 155.8 0.0 1.4e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family DHFR_1 PF00186.19 EDP42555.1 - 5.1e-22 78.3 0.0 3.2e-10 39.9 0.0 3.1 2 1 0 2 2 2 2 Dihydrofolate reductase tRNA-synt_1c PF00749.21 EDP42556.1 - 1e-104 349.8 0.0 1e-104 349.8 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EDP42556.1 - 1e-32 113.4 0.0 1.7e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.6 EDP42556.1 - 0.00053 20.0 0.8 0.0017 18.3 0.8 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP42556.1 - 0.012 15.8 0.0 0.012 15.8 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 EDP42556.1 - 0.028 13.8 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain WASH-7_C PF14746.6 EDP42556.1 - 0.44 10.2 0.0 0.44 10.2 0.0 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal BRF1 PF07741.13 EDP42556.1 - 4.3 7.7 8.1 14 6.1 8.1 1.9 1 0 0 1 1 1 0 Brf1-like TBP-binding domain LSM PF01423.22 EDP42557.1 - 4.7e-11 42.2 0.0 6.3e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDP42557.1 - 0.022 14.4 0.1 0.039 13.6 0.1 1.4 1 0 0 1 1 1 0 Hfq protein adh_short PF00106.25 EDP42558.1 - 3.2e-83 278.0 8.6 4.9e-42 143.6 0.7 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDP42558.1 - 8.2e-69 231.7 7.1 3.3e-34 118.5 0.9 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP42558.1 - 3.6e-30 105.2 5.3 5.3e-17 62.3 0.3 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.19 EDP42558.1 - 2e-19 69.4 0.0 4.4e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EDP42558.1 - 0.0011 19.1 0.0 0.021 14.9 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase THF_DHG_CYH_C PF02882.19 EDP42558.1 - 0.0077 15.6 0.2 1.2 8.5 0.0 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EDP42558.1 - 0.12 12.3 5.7 3.3 7.6 0.7 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PglL_A PF15864.5 EDP42558.1 - 2.3 8.0 8.2 11 5.8 1.1 2.6 2 0 0 2 2 2 0 Protein glycosylation ligase DUF543 PF04418.12 EDP42558.1 - 3.3 7.8 5.0 15 5.7 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF543) NDUFA12 PF05071.16 EDP42559.1 - 1.4e-25 90.0 6.5 1.6e-25 89.7 6.5 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Polysacc_synt_4 PF04669.13 EDP42560.1 - 1.5e-18 67.0 2.3 4.8e-17 62.1 2.3 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Asn_synthase PF00733.21 EDP42561.1 - 2.9e-20 73.3 1.6 1.8e-10 41.0 0.3 3.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDP42561.1 - 0.00015 21.7 0.0 0.00046 20.1 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDP42561.1 - 0.00031 21.0 0.0 0.00081 19.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF4880 PF16220.5 EDP42561.1 - 0.78 9.7 4.4 5.6 6.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) TMEM70 PF06979.12 EDP42562.1 - 0.00013 22.4 0.4 0.00021 21.7 0.4 1.3 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex DUF4645 PF15488.6 EDP42563.1 - 0.028 13.9 1.0 0.042 13.3 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4645) Leader_Trp PF08255.11 EDP42563.1 - 0.11 12.5 0.9 0.31 11.1 0.9 1.8 1 0 0 1 1 1 0 Trp-operon Leader Peptide PRNT PF15174.6 EDP42563.1 - 1.9 8.6 4.5 1.3 9.1 0.8 2.2 2 0 0 2 2 2 0 Prion-related protein testis-specific MnmE_helical PF12631.7 EDP42564.1 - 1.4e-29 103.8 0.0 2.2e-29 103.1 0.0 1.3 1 1 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EDP42564.1 - 1.5e-21 76.9 0.0 3.4e-21 75.7 0.0 1.7 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EDP42564.1 - 3.4e-20 72.2 0.0 9.4e-20 70.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP42564.1 - 1.7e-08 34.2 0.1 5.9e-08 32.4 0.0 2.0 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDP42564.1 - 2.7e-05 24.3 0.0 0.00016 21.8 0.0 2.0 1 1 1 2 2 2 1 Dynamin family AAA_25 PF13481.6 EDP42564.1 - 0.00038 20.1 1.4 0.071 12.7 0.0 3.1 2 1 1 3 3 3 1 AAA domain Roc PF08477.13 EDP42564.1 - 0.0031 17.7 0.0 0.021 15.0 0.0 2.5 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP42564.1 - 0.0094 15.4 0.0 0.27 10.7 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDP42564.1 - 0.016 15.2 0.0 0.22 11.4 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 EDP42564.1 - 0.036 13.6 0.0 2 7.9 0.0 2.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EDP42564.1 - 0.055 12.8 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 AIG1 family AAA_28 PF13521.6 EDP42564.1 - 0.15 12.3 1.0 1 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EDP42564.1 - 0.24 11.0 0.3 0.6 9.7 0.0 1.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF5102 PF17104.5 EDP42565.1 - 1.4e-49 169.7 1.4 1.8e-49 169.4 1.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) Clathrin_bdg PF15045.6 EDP42565.1 - 0.0021 18.0 0.0 0.11 12.6 0.0 2.5 2 0 0 2 2 2 1 Clathrin-binding box of Aftiphilin, vesicle trafficking FEZ PF07763.13 EDP42565.1 - 0.003 17.3 0.2 0.15 11.8 0.0 2.6 2 1 1 3 3 3 1 FEZ-like protein Abhydrolase_6 PF12697.7 EDP42566.1 - 1.1e-24 88.3 0.5 1.6e-24 87.7 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP42566.1 - 1.2e-10 41.1 0.0 1.6e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP42566.1 - 3.2e-09 36.8 0.0 6.2e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EDP42566.1 - 5.7e-08 33.2 0.0 1.3e-07 31.9 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain Lipase_3 PF01764.25 EDP42566.1 - 0.013 15.3 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) LIDHydrolase PF10230.9 EDP42566.1 - 0.024 14.2 0.0 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase DUF2974 PF11187.8 EDP42566.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF900 PF05990.12 EDP42566.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EDP42566.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EDP42566.1 - 0.22 11.3 0.0 0.41 10.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Aldo_ket_red PF00248.21 EDP42567.1 - 8.9e-56 189.2 0.0 1e-55 189.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Leptin PF02024.15 EDP42567.1 - 0.19 11.5 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Leptin Phosphoesterase PF04185.14 EDP42568.1 - 3e-80 270.1 1.2 4.5e-80 269.5 1.2 1.2 1 0 0 1 1 1 1 Phosphoesterase family Asp PF00026.23 EDP42569.1 - 3.9e-44 151.4 6.2 1.1e-43 149.9 6.2 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP42569.1 - 2.3e-08 34.6 0.8 0.00068 20.2 0.1 2.6 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP42569.1 - 4.5e-08 33.5 0.2 0.0019 18.7 0.0 2.7 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 EDP42569.1 - 1.3e-05 25.5 0.0 0.0028 17.9 0.0 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDP42569.1 - 4e-05 23.4 0.0 0.00033 20.5 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.23 EDP42570.1 - 2.7e-38 132.2 4.7 1.8e-37 129.5 4.7 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EDP42570.1 - 0.004 16.9 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EDP42570.1 - 0.0063 17.1 1.0 1.3 9.7 0.0 3.3 2 1 0 2 2 2 1 Aspartyl protease TAXi_N PF14543.6 EDP42570.1 - 0.0092 16.2 0.2 2.3 8.4 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EDP42570.1 - 0.017 15.6 0.4 5 7.8 0.0 3.1 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Asp PF00026.23 EDP42571.1 - 2.3e-39 135.7 4.4 7.5e-39 134.0 4.4 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP42571.1 - 5.4e-06 27.0 2.1 0.017 15.7 0.2 2.5 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP42571.1 - 2.4e-05 24.8 2.1 0.17 12.4 0.1 2.5 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 EDP42571.1 - 0.0051 17.1 0.8 0.36 11.1 0.4 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp PF00026.23 EDP42572.1 - 9.5e-22 77.8 2.1 2.7e-21 76.3 2.1 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP42572.1 - 6.2e-05 23.6 1.3 0.082 13.6 0.2 2.7 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP42572.1 - 0.004 17.7 0.2 1.1 9.8 0.0 2.6 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp PF00026.23 EDP42573.1 - 1.3e-28 100.4 2.8 2.8e-28 99.2 2.8 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP42573.1 - 1.1e-07 32.4 0.2 0.0018 18.9 0.0 2.7 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP42573.1 - 8e-05 23.1 0.0 0.23 12.0 0.0 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Lipocalin_8 PF16585.5 EDP42574.1 - 1.2 9.6 16.3 54 4.2 0.1 6.8 2 2 4 8 8 8 0 Lipocalin-like domain DUF4124 PF13511.6 EDP42574.1 - 1.2 9.5 59.8 24 5.4 1.2 13.2 2 2 9 13 13 13 0 Domain of unknown function (DUF4124) WD40_3 PF15911.5 EDP42574.1 - 2.7 8.1 11.1 1.1e+02 2.9 0.0 6.1 7 0 0 7 7 7 0 WD domain, G-beta repeat PNTB PF02233.16 EDP42576.1 - 0.4 9.5 5.5 0.54 9.1 5.5 1.4 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit DUF155 PF02582.14 EDP42577.1 - 2.8e-46 157.8 0.0 4.4e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CTD PF12815.7 EDP42578.1 - 0.07 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 UPF0121 PF03661.13 EDP42580.1 - 2.5e-47 161.3 5.8 2.8e-47 161.1 5.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) CTV_P6 PF06706.11 EDP42580.1 - 1.4 8.6 4.0 6 6.7 0.1 3.2 3 0 0 3 3 3 0 Citrus tristeza virus 6-kDa protein Rad51 PF08423.11 EDP42581.1 - 9.7e-19 67.6 0.0 3.4e-17 62.6 0.0 2.7 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 EDP42581.1 - 0.0011 18.5 0.3 0.0045 16.5 0.1 1.8 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EDP42581.1 - 0.0018 17.7 0.2 0.0043 16.4 0.1 1.7 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 EDP42581.1 - 0.014 15.0 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpb1_5 PF04998.17 EDP42582.1 - 9.9e-103 343.2 0.0 1.4e-102 342.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDP42582.1 - 6.3e-74 247.7 0.0 1e-73 247.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EDP42582.1 - 1.1e-57 195.0 0.0 2e-57 194.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_1 PF04997.12 EDP42582.1 - 9.4e-51 173.0 0.0 1.3e-50 172.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_7 PF04990.12 EDP42582.1 - 5.1e-47 159.2 0.3 9.6e-47 158.4 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 EDP42582.1 - 2.9e-46 157.3 0.0 5.9e-46 156.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDP42582.1 - 1e-37 128.3 0.0 2.4e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EDP42582.1 - 1.1e-29 101.1 239.2 0.004 17.4 9.9 16.1 4 1 18 23 23 23 23 RNA polymerase Rpb1 C-terminal repeat UIM PF02809.20 EDP42583.1 - 1.2e-05 24.8 13.2 0.0046 16.8 1.4 2.8 3 0 0 3 3 3 2 Ubiquitin interaction motif Hid1 PF12722.7 EDP42584.1 - 7.2e-100 335.4 9.7 3.9e-98 329.6 9.7 2.1 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EDP42584.1 - 3.4e-46 157.9 1.8 4.3e-46 157.6 1.8 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Cnd1_N PF12922.7 EDP42584.1 - 0.086 12.7 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term DUF543 PF04418.12 EDP42585.1 - 0.89 9.6 4.0 0.27 11.2 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF543) Pkinase PF00069.25 EDP42586.1 - 1.1e-69 234.8 0.0 1.8e-69 234.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Abhydrolase_3 PF07859.13 EDP42586.1 - 5.7e-45 153.8 0.0 9.7e-45 153.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 EDP42586.1 - 6.5e-31 107.5 0.0 1e-30 106.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Say1_Mug180 PF10340.9 EDP42586.1 - 3.1e-12 46.1 0.0 7.9e-12 44.7 0.0 1.6 2 0 0 2 2 2 1 Steryl acetyl hydrolase Pkinase_fungal PF17667.1 EDP42586.1 - 0.0024 16.7 0.2 0.0053 15.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDP42586.1 - 0.003 16.9 0.0 0.014 14.8 0.0 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EDP42586.1 - 0.0063 16.5 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family COesterase PF00135.28 EDP42586.1 - 0.032 13.1 0.0 0.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Carboxylesterase family Kdo PF06293.14 EDP42586.1 - 0.038 13.3 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EDP42586.1 - 0.04 13.4 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 EDP42586.1 - 0.061 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 EDP42586.1 - 0.2 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase NAC PF01849.18 EDP42588.1 - 6e-15 55.0 0.0 1.2e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 NAC domain ANAPC_CDC26 PF10471.9 EDP42588.1 - 0.35 11.7 4.6 0.56 11.1 4.6 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Proteasome PF00227.26 EDP42589.1 - 6.1e-47 159.6 0.0 7.9e-47 159.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Tht1 PF04163.12 EDP42589.1 - 0.072 11.8 0.3 0.09 11.5 0.3 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein SNARE_assoc PF09335.11 EDP42590.1 - 2.4e-05 24.8 2.0 2.4e-05 24.8 2.0 1.8 2 1 0 2 2 2 1 SNARE associated Golgi protein Cytochrome-c551 PF10643.9 EDP42590.1 - 0.051 13.2 0.7 0.074 12.6 0.7 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF2975 PF11188.8 EDP42590.1 - 0.056 13.3 0.2 0.056 13.3 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) PUF PF00806.19 EDP42591.1 - 1.6e-08 33.7 3.5 0.0033 17.0 0.0 5.2 7 0 0 7 7 7 2 Pumilio-family RNA binding repeat PI_PP_C PF18365.1 EDP42591.1 - 0.077 13.0 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain RNase_PH PF01138.21 EDP42592.1 - 3.9e-19 69.5 0.2 8e-19 68.4 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 GHMP_kinases_N PF00288.26 EDP42593.1 - 1.1e-07 32.0 0.6 2.2e-07 31.0 0.6 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDP42593.1 - 1.4e-06 28.5 0.0 3.7e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal ABC_tran PF00005.27 EDP42594.1 - 2.2e-45 154.6 0.0 7e-23 81.7 0.0 3.2 2 1 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDP42594.1 - 5.7e-26 90.4 4.4 5.7e-26 90.4 4.4 3.3 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 EDP42594.1 - 5.4e-17 62.6 5.8 1.3e-05 25.2 0.1 4.5 4 1 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDP42594.1 - 3.4e-09 36.5 0.0 0.014 14.9 0.0 4.4 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDP42594.1 - 2.9e-07 30.6 0.2 0.015 15.4 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EDP42594.1 - 7e-07 28.9 0.1 0.014 15.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 EDP42594.1 - 7.6e-07 29.5 0.4 0.015 15.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EDP42594.1 - 1.7e-06 28.0 0.0 0.021 14.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EDP42594.1 - 7e-06 26.4 0.0 0.064 13.5 0.0 3.3 3 1 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EDP42594.1 - 7.4e-06 26.5 2.6 0.51 10.9 0.0 4.0 5 0 0 5 5 3 2 AAA domain AAA_16 PF13191.6 EDP42594.1 - 4.9e-05 23.8 1.9 0.15 12.4 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EDP42594.1 - 6e-05 23.6 6.1 0.16 12.5 0.0 4.4 5 0 0 5 5 5 2 AAA domain AAA_15 PF13175.6 EDP42594.1 - 0.00013 21.8 0.5 0.25 11.0 0.0 3.3 4 0 0 4 4 4 2 AAA ATPase domain MeaB PF03308.16 EDP42594.1 - 0.00021 20.3 0.0 0.15 11.0 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDP42594.1 - 0.00052 20.0 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 EDP42594.1 - 0.00097 18.9 0.0 2 8.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDP42594.1 - 0.0015 18.9 0.0 0.75 10.2 0.0 2.5 2 0 0 2 2 2 1 RNA helicase DUF87 PF01935.17 EDP42594.1 - 0.0022 18.2 2.5 0.029 14.4 0.0 3.2 3 0 0 3 3 3 1 Helicase HerA, central domain DUF815 PF05673.13 EDP42594.1 - 0.0032 16.7 0.0 0.23 10.6 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA PF00004.29 EDP42594.1 - 0.0056 17.1 0.0 2 8.9 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EDP42594.1 - 0.0072 16.5 0.0 4 7.7 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EDP42594.1 - 0.0077 15.8 0.0 4.7 6.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 EDP42594.1 - 0.013 15.0 0.2 6.4 6.3 0.0 3.5 3 1 0 3 3 3 0 AAA domain TsaE PF02367.17 EDP42594.1 - 0.014 15.4 0.0 1.1 9.3 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EDP42594.1 - 0.016 15.2 0.2 5.8 6.9 0.0 3.5 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EDP42594.1 - 0.018 14.6 0.0 5.1 6.6 0.0 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EDP42594.1 - 0.043 13.0 0.0 7.3 5.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 EDP42594.1 - 0.044 13.8 0.0 12 5.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDP42594.1 - 0.047 13.6 0.0 7.4 6.4 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_33 PF13671.6 EDP42594.1 - 0.05 13.8 8.9 0.86 9.8 0.0 3.3 4 1 0 4 4 2 0 AAA domain SbcCD_C PF13558.6 EDP42594.1 - 0.15 12.3 1.2 6.6 7.0 0.2 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.21 EDP42594.1 - 0.15 11.4 0.0 5.7 6.3 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Dynamin_N PF00350.23 EDP42594.1 - 0.28 11.2 3.5 13 5.8 0.1 3.9 3 1 1 4 4 4 0 Dynamin family CLP1_P PF16575.5 EDP42594.1 - 3.4 7.4 5.8 2.5 7.8 0.1 3.3 4 1 0 4 4 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop BSD PF03909.17 EDP42595.1 - 2.4e-19 69.1 0.1 8e-17 61.0 0.1 3.1 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 EDP42595.1 - 3.5e-13 49.7 0.0 1.2e-12 47.9 0.0 2.0 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain HSCB_C PF07743.13 EDP42595.1 - 0.0053 17.2 0.5 0.02 15.4 0.5 2.0 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain IL10 PF00726.17 EDP42595.1 - 0.046 13.2 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Interleukin 10 CDC37_N PF03234.14 EDP42596.1 - 7.9e-37 127.0 0.5 7.9e-37 127.0 0.5 2.5 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EDP42596.1 - 2.5e-26 91.9 0.7 8e-26 90.3 0.1 1.9 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EDP42596.1 - 6.3e-16 58.3 0.1 3.3e-15 56.0 0.0 2.2 2 0 0 2 2 2 1 Cdc37 C terminal domain Blo-t-5 PF11642.8 EDP42596.1 - 0.064 13.2 0.5 0.2 11.6 0.5 1.8 1 0 0 1 1 1 0 Mite allergen Blo t 5 LSM14 PF12701.7 EDP42597.1 - 2e-25 88.7 0.0 3.2e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EDP42597.1 - 3e-08 33.7 0.0 8.6e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Ataxin 2 SM domain FDF PF09532.10 EDP42597.1 - 0.00016 22.5 11.2 0.00047 21.0 2.9 3.4 1 1 1 2 2 2 1 FDF domain LAP1C PF05609.12 EDP42597.1 - 1.1 8.3 8.6 1.5 7.9 8.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Coiled-coil_56 PF09813.9 EDP42599.1 - 0.00037 20.5 0.0 0.00052 20.0 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 BPL_LplA_LipB PF03099.19 EDP42600.1 - 5.8e-08 32.7 0.0 9.9e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF3712 PF12505.8 EDP42601.1 - 4.8e-109 359.6 33.2 4.9e-25 88.2 0.3 9.4 9 0 0 9 9 9 7 Protein of unknown function (DUF3712) LEA_2 PF03168.13 EDP42601.1 - 3.4e-08 33.9 2.3 0.0013 19.2 0.0 5.8 6 0 0 6 6 6 2 Late embryogenesis abundant protein Actin PF00022.19 EDP42602.1 - 0.0024 16.6 0.0 0.0026 16.4 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 EDP42603.1 - 1e-28 100.1 0.0 5.5e-19 68.1 0.1 2.2 2 0 0 2 2 2 2 Actin NAD_binding_5 PF07994.12 EDP42604.1 - 8e-146 485.5 0.0 1e-145 485.2 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EDP42604.1 - 3e-43 146.5 0.0 5.1e-43 145.8 0.0 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase DUF89 PF01937.19 EDP42605.1 - 1.4e-90 303.8 0.1 1.1e-47 162.8 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function DUF89 Ala_racemase_N PF01168.20 EDP42605.1 - 2.9e-11 43.4 0.2 1.6e-09 37.8 0.2 2.6 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain SBDS_C PF09377.10 EDP42606.1 - 1.5e-34 118.5 1.5 2.3e-34 117.9 0.7 1.6 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 EDP42606.1 - 1.3e-33 115.0 0.8 2.2e-33 114.2 0.4 1.7 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Pre-PUA PF17832.1 EDP42606.1 - 0.07 13.8 0.0 0.19 12.4 0.0 1.8 1 0 0 1 1 1 0 Pre-PUA-like domain Sulfate_transp PF00916.20 EDP42607.1 - 9.3e-67 225.4 18.3 1.5e-66 224.7 18.3 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDP42607.1 - 1.1e-08 34.7 0.0 3e-08 33.3 0.0 1.8 1 1 1 2 2 2 1 STAS domain UCR_UQCRX_QCR9 PF05365.12 EDP42607.1 - 0.012 15.5 0.0 0.054 13.5 0.0 2.1 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF4645 PF15488.6 EDP42607.1 - 0.06 12.8 0.1 0.095 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4645) DUF2157 PF09925.9 EDP42607.1 - 4.4 7.1 10.8 0.035 13.9 1.0 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) NCBP3 PF10309.9 EDP42608.1 - 2.2e-15 56.2 0.0 3.6e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 DEAD PF00270.29 EDP42609.1 - 5.3e-45 153.3 1.1 7.3e-45 152.9 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42609.1 - 1e-31 109.5 0.3 4.2e-31 107.6 0.1 2.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP42609.1 - 2.7e-06 27.5 0.0 5.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDP42609.1 - 2e-05 24.9 0.4 0.0025 18.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP42609.1 - 0.00038 20.2 0.1 0.00071 19.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain tRNA-synt_1b PF00579.25 EDP42609.1 - 0.02 14.2 0.2 0.051 12.9 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) DUF1664 PF07889.12 EDP42609.1 - 0.058 13.4 0.6 7.9 6.5 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Flavi_DEAD PF07652.14 EDP42609.1 - 0.073 13.0 0.2 0.33 10.9 0.0 2.2 3 0 0 3 3 3 0 Flavivirus DEAD domain CMS1 PF14617.6 EDP42609.1 - 0.091 12.1 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EDP42609.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Helicase SLAC1 PF03595.17 EDP42610.1 - 8.3e-46 156.7 23.0 9.2e-46 156.6 23.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel PMT PF02366.18 EDP42611.1 - 5e-77 258.8 17.2 9.6e-77 257.9 17.2 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDP42611.1 - 3.4e-53 180.2 12.3 3.4e-53 180.2 12.3 2.0 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDP42611.1 - 2.5e-17 63.3 0.0 4.5e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 MIR domain CitMHS PF03600.16 EDP42611.1 - 0.0058 15.9 0.2 0.011 14.9 0.2 1.5 1 0 0 1 1 1 1 Citrate transporter Peptidase_M15 PF01427.17 EDP42611.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 D-ala-D-ala dipeptidase WD40 PF00400.32 EDP42612.1 - 1.2e-44 149.4 17.7 7.8e-12 45.5 1.0 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42612.1 - 1.2e-17 64.0 2.8 0.00042 20.6 0.1 6.1 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP42612.1 - 5.3e-07 28.9 0.9 0.0028 16.7 0.0 4.3 1 1 4 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDP42612.1 - 0.00011 21.0 4.9 0.14 10.7 0.0 4.2 2 1 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDP42612.1 - 0.00058 18.7 0.4 0.8 8.4 0.0 3.6 1 1 2 4 4 4 2 Nup133 N terminal like eIF2A PF08662.11 EDP42612.1 - 0.0011 18.9 0.2 3.2 7.6 0.0 3.7 1 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EDP42612.1 - 0.0011 17.4 0.0 0.0026 16.2 0.0 1.6 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 EDP42612.1 - 0.0024 16.8 1.2 0.0042 16.1 0.0 2.0 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 EDP42612.1 - 0.0085 15.8 0.0 5.3 6.7 0.0 3.5 2 1 1 3 3 3 1 TUP1-like enhancer of split Coatomer_WDAD PF04053.14 EDP42612.1 - 0.02 14.0 0.0 0.036 13.1 0.0 1.3 1 1 0 1 1 1 0 Coatomer WD associated region dsrm PF00035.26 EDP42613.1 - 7.3e-09 36.2 0.0 1.8e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EDP42613.1 - 0.00035 21.1 0.0 0.00072 20.1 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EDP42613.1 - 0.00036 20.7 0.0 0.00077 19.6 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like SRP54 PF00448.22 EDP42614.1 - 8.3e-34 116.9 0.0 4.7e-32 111.2 0.0 2.3 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EDP42614.1 - 3.5e-27 96.1 7.6 8.5e-27 94.8 7.6 1.6 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal MeaB PF03308.16 EDP42614.1 - 4.8e-06 25.8 0.0 1.2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54_N PF02881.19 EDP42614.1 - 4.9e-06 26.7 0.0 1.7e-05 25.0 0.0 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 EDP42614.1 - 0.004 17.2 0.0 0.021 14.9 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EDP42614.1 - 0.018 14.8 0.4 0.07 12.8 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP42614.1 - 0.05 14.0 0.1 0.33 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 EDP42614.1 - 0.051 13.6 1.3 0.52 10.4 0.3 2.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase EcoEI_R_C PF08463.10 EDP42614.1 - 0.11 12.6 0.5 0.9 9.6 0.0 2.3 3 0 0 3 3 3 0 EcoEI R protein C-terminal VirC1 PF07015.11 EDP42614.1 - 0.14 11.4 0.2 42 3.3 0.0 3.1 3 0 0 3 3 3 0 VirC1 protein ArsA_ATPase PF02374.15 EDP42614.1 - 0.16 11.1 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Anion-transporting ATPase Na_H_Exchanger PF00999.21 EDP42615.1 - 1.9e-67 227.7 37.9 2.4e-67 227.4 37.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PDR_CDR PF06422.12 EDP42615.1 - 0.034 14.1 0.6 0.21 11.5 0.6 2.4 1 0 0 1 1 1 0 CDR ABC transporter Abhydrolase_1 PF00561.20 EDP42616.1 - 1.5e-09 37.9 0.0 1.9e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP42616.1 - 0.0021 18.7 0.0 0.0027 18.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP42616.1 - 0.013 14.7 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SWIRM-assoc_2 PF16496.5 EDP42617.1 - 3.5e-33 115.1 5.9 3.5e-33 115.1 5.9 2.6 2 1 0 2 2 2 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 EDP42617.1 - 1.3e-31 108.7 0.2 3.2e-31 107.5 0.2 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EDP42617.1 - 1.8e-28 98.3 9.1 4.2e-28 97.1 9.1 1.7 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EDP42617.1 - 1.9e-10 40.8 0.0 3.8e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP42617.1 - 2.3e-07 30.9 0.0 6.5e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EDP42617.1 - 8e-07 28.8 1.1 1.5e-06 27.9 1.1 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_7 PF15963.5 EDP42617.1 - 0.0068 16.3 1.0 0.037 13.9 0.0 2.6 2 0 0 2 2 2 1 Myb DNA-binding like RhoGAP PF00620.27 EDP42618.1 - 2.2e-39 134.7 0.0 5e-39 133.6 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 EDP42618.1 - 8.3e-09 35.6 0.0 3.1e-08 33.8 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 EDP42618.1 - 2.1e-08 34.6 0.0 8.3e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 RasGEF domain Cellulase PF00150.18 EDP42619.1 - 6.9e-18 65.1 7.6 1.4e-17 64.0 7.6 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SelP_N PF04592.14 EDP42619.1 - 1.3 8.4 25.7 2.4 7.5 25.7 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 EDP42619.1 - 2.9 6.6 5.0 5.1 5.7 5.0 1.4 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 EDP42619.1 - 3.3 7.5 17.8 1.1 9.1 12.1 2.3 2 0 0 2 2 2 0 SPX domain NRDE-2 PF08424.10 EDP42622.1 - 3.8e-10 39.4 0.1 5e-06 25.9 0.0 4.5 3 3 1 4 4 4 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EDP42622.1 - 3.9e-10 39.7 31.7 3.8 8.6 0.5 12.7 9 4 4 14 14 13 2 Tetratricopeptide repeat Suf PF05843.14 EDP42622.1 - 2.8e-08 34.1 5.6 8e-05 22.8 1.1 5.2 4 1 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EDP42622.1 - 6e-07 29.9 6.5 18 5.9 0.2 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42622.1 - 3e-06 26.9 15.9 1.2 9.4 0.1 8.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP42622.1 - 4.6e-06 26.8 10.6 4.3 7.7 0.4 7.1 7 1 0 7 7 7 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDP42622.1 - 6.8e-06 26.1 9.1 0.88 9.6 0.3 6.9 7 1 1 8 8 8 1 Mad3/BUB1 homology region 1 TPR_17 PF13431.6 EDP42622.1 - 7e-05 22.9 6.3 7 7.3 0.0 6.6 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP42622.1 - 0.00018 21.5 6.7 11 6.6 0.1 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EDP42622.1 - 0.00065 19.2 0.1 2.2 7.6 0.0 4.5 4 1 1 5 5 5 1 MalT-like TPR region MIT PF04212.18 EDP42622.1 - 0.0035 17.4 0.1 0.076 13.1 0.1 3.4 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 EDP42622.1 - 0.0096 15.7 5.5 31 4.6 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat LemA PF04011.12 EDP42622.1 - 0.045 13.6 1.5 0.2 11.5 0.5 2.4 1 1 1 2 2 2 0 LemA family SNAP PF14938.6 EDP42622.1 - 0.74 9.2 11.0 7.3 5.9 1.0 4.5 2 1 5 7 7 7 0 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 EDP42622.1 - 0.94 10.2 15.1 62 4.4 0.1 7.1 7 1 2 9 9 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP42622.1 - 0.94 10.3 13.2 49 4.9 0.0 7.6 9 0 0 9 9 8 0 Tetratricopeptide repeat UCH PF00443.29 EDP42623.1 - 5.6e-43 147.3 0.0 7.3e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP42623.1 - 4.3e-13 49.5 0.0 6.9e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase R3H PF01424.22 EDP42624.1 - 2.8e-08 33.6 0.0 5.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EDP42624.1 - 4.3e-07 29.7 0.0 8.4e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EDP42625.1 - 1.5e-31 108.0 3.8 2e-07 31.6 0.7 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42625.1 - 2.1e-08 34.4 0.0 0.27 11.6 0.0 6.3 3 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Striatin PF08232.12 EDP42625.1 - 0.00033 21.3 0.0 0.00033 21.3 0.0 2.4 3 0 0 3 3 3 1 Striatin family Ge1_WD40 PF16529.5 EDP42625.1 - 0.022 13.7 0.1 0.66 8.9 0.0 3.1 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FXR_C1 PF16096.5 EDP42626.1 - 0.021 15.0 1.6 0.065 13.4 1.6 1.8 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Med26 PF08711.11 EDP42627.1 - 1.8e-08 34.3 0.0 3.2e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain S4 PF01479.25 EDP42628.1 - 8.6e-13 47.8 0.3 8.6e-13 47.8 0.3 2.5 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EDP42628.1 - 1.5e-06 29.0 0.2 3.4e-06 27.9 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 EDP42629.1 - 4.1e-35 119.7 4.4 4.8e-35 119.4 3.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e RNA_replicase_B PF03431.13 EDP42629.1 - 0.087 11.3 0.2 0.1 11.1 0.2 1.0 1 0 0 1 1 1 0 RNA replicase, beta-chain PUA PF01472.20 EDP42629.1 - 0.17 11.9 1.4 0.39 10.7 0.5 2.0 2 1 0 2 2 2 0 PUA domain Amidohydro_1 PF01979.20 EDP42630.1 - 4.8e-09 36.0 0.0 7.2e-08 32.1 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.11 EDP42630.1 - 4.4e-07 29.7 0.4 1.3e-06 28.2 0.1 1.9 2 0 0 2 2 2 1 Amidohydrolase family Ank_2 PF12796.7 EDP42631.1 - 2.5e-15 56.8 0.2 8.8e-13 48.7 0.2 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP42631.1 - 8.1e-12 44.2 0.3 0.0013 19.0 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EDP42631.1 - 1.4e-10 41.1 0.1 0.00038 20.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EDP42631.1 - 2.1e-10 40.9 0.6 0.0018 18.8 0.2 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDP42631.1 - 4.3e-09 36.5 2.2 0.0005 20.3 0.0 3.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Pes-10 PF07149.11 EDP42631.1 - 0.3 10.1 4.3 0.42 9.6 4.3 1.3 1 0 0 1 1 1 0 Pes-10 Atrophin-1 PF03154.15 EDP42631.1 - 0.5 8.6 8.3 0.64 8.2 8.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family Sds3 PF08598.11 EDP42632.1 - 6.7e-23 81.8 6.5 6.7e-23 81.8 6.5 2.1 2 0 0 2 2 2 1 Sds3-like BCDHK_Adom3 PF10436.9 EDP42633.1 - 3.8e-63 212.2 0.0 5.2e-63 211.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDP42633.1 - 1.6e-10 41.5 0.0 3.1e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDP42633.1 - 2e-05 24.4 0.0 3.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MASE1 PF05231.14 EDP42633.1 - 0.16 11.1 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 MASE1 Mt_ATP-synt_B PF05405.14 EDP42634.1 - 9.2e-43 145.7 2.7 1.1e-42 145.4 2.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Pkinase PF00069.25 EDP42635.1 - 4e-71 239.5 0.0 4.6e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42635.1 - 6.2e-32 110.9 0.0 9.7e-32 110.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase VPS9 PF02204.18 EDP42636.1 - 2.8e-30 104.6 0.0 4.7e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EDP42636.1 - 6.4e-14 52.0 0.0 3.7e-12 46.4 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) CUE PF02845.16 EDP42636.1 - 4.5e-10 39.0 0.1 9.9e-10 37.9 0.1 1.6 1 0 0 1 1 1 1 CUE domain DMA PF03474.14 EDP42636.1 - 0.00039 20.0 0.0 0.00073 19.1 0.0 1.4 1 0 0 1 1 1 1 DMRTA motif SOG2 PF10428.9 EDP42636.1 - 7.2 5.7 9.9 2.3 7.3 2.6 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein RRM_1 PF00076.22 EDP42637.1 - 6.6e-07 29.1 0.5 0.015 15.1 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EDP42637.1 - 0.14 11.9 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain HMG_CoA_synt_N PF01154.17 EDP42638.1 - 1.1e-87 292.4 0.1 1.8e-87 291.7 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 EDP42638.1 - 9.2e-77 258.4 0.2 1.3e-76 257.9 0.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal ACP_syn_III_C PF08541.10 EDP42638.1 - 0.0098 16.0 0.2 0.072 13.3 0.1 2.3 1 1 1 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal YjeJ PF15922.5 EDP42638.1 - 0.015 14.5 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 YjeJ-like AAA PF00004.29 EDP42640.1 - 2.1e-83 277.3 0.0 3.5e-41 140.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP42640.1 - 1.5e-25 88.7 4.2 3.7e-12 45.8 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDP42640.1 - 6.4e-13 49.4 0.3 2.9e-07 31.0 0.1 3.8 2 1 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 EDP42640.1 - 6.4e-12 45.5 0.0 1.5e-06 28.1 0.0 3.2 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDP42640.1 - 1.6e-10 41.1 0.2 2.9e-05 24.1 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDP42640.1 - 2.7e-09 37.4 1.5 0.00055 20.2 0.3 4.0 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDP42640.1 - 1.1e-06 28.9 0.0 0.02 15.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EDP42640.1 - 2e-06 28.1 0.0 0.0041 17.5 0.0 2.5 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.13 EDP42640.1 - 3.6e-06 26.4 0.0 0.015 14.5 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_2 PF07724.14 EDP42640.1 - 1e-05 25.8 0.0 0.021 14.9 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 EDP42640.1 - 1.2e-05 25.3 0.0 0.018 15.0 0.0 2.8 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 EDP42640.1 - 5.9e-05 23.1 0.0 0.0058 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDP42640.1 - 0.0001 22.3 0.1 0.14 12.0 0.0 3.6 3 1 0 4 4 3 1 NACHT domain AAA_28 PF13521.6 EDP42640.1 - 0.00015 22.1 0.2 0.27 11.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 EDP42640.1 - 0.00017 21.0 0.1 0.091 12.1 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDP42640.1 - 0.00029 20.6 0.0 0.058 13.1 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 EDP42640.1 - 0.00031 20.6 0.0 0.44 10.4 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDP42640.1 - 0.00064 20.3 0.0 0.11 13.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDP42640.1 - 0.00078 19.2 0.0 0.015 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDP42640.1 - 0.0014 18.2 0.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region TsaE PF02367.17 EDP42640.1 - 0.0014 18.6 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EDP42640.1 - 0.0016 18.1 5.4 0.26 10.8 0.5 4.2 2 2 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EDP42640.1 - 0.0016 18.2 0.0 0.23 11.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EDP42640.1 - 0.0081 16.1 0.0 1.4 8.8 0.0 3.0 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EDP42640.1 - 0.012 16.1 0.0 0.18 12.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 EDP42640.1 - 0.02 14.6 0.1 0.38 10.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EDP42640.1 - 0.036 13.8 0.0 0.76 9.5 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Sigma54_activ_2 PF14532.6 EDP42640.1 - 0.04 14.0 0.0 4.6 7.4 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_17 PF13207.6 EDP42640.1 - 0.048 14.1 0.0 20 5.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 EDP42640.1 - 0.048 12.8 0.0 0.65 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase PF06745.13 EDP42640.1 - 0.056 12.8 0.0 2.8 7.2 0.0 2.8 3 0 0 3 3 3 0 KaiC AAA_19 PF13245.6 EDP42640.1 - 0.074 13.4 0.1 1.8 8.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EDP42640.1 - 0.089 12.5 0.0 5 6.8 0.0 3.4 3 1 1 4 4 4 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EDP42640.1 - 0.1 11.8 0.1 2.1 7.6 0.0 2.8 2 1 1 3 3 3 0 Zeta toxin PhoH PF02562.16 EDP42640.1 - 0.16 11.4 0.4 0.79 9.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein FAD_binding_3 PF01494.19 EDP42641.1 - 4.8e-19 68.8 0.3 1.4e-08 34.4 0.5 2.2 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 EDP42641.1 - 0.0028 16.8 0.0 0.0046 16.0 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Hpt PF01627.23 EDP42641.1 - 0.023 14.9 1.2 0.051 13.8 0.4 2.0 2 0 0 2 2 2 0 Hpt domain MMS19_N PF14500.6 EDP42642.1 - 6.3e-71 239.0 4.9 7.3e-69 232.2 0.0 5.0 3 3 2 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 EDP42642.1 - 4.4e-48 164.4 0.2 4.4e-48 164.4 0.2 3.1 4 1 0 4 4 4 1 RNAPII transcription regulator C-terminal MMS22L_C PF14911.6 EDP42642.1 - 2.7e-05 23.4 2.9 0.18 10.8 0.2 3.3 3 0 0 3 3 3 2 S-phase genomic integrity recombination mediator, C-terminal IFN-gamma PF00714.17 EDP42642.1 - 0.048 13.5 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Interferon gamma DUF3361 PF11841.8 EDP42642.1 - 0.14 12.1 1.7 15 5.5 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) HEAT PF02985.22 EDP42642.1 - 9.8 6.7 18.2 5.7 7.5 0.0 6.4 6 0 0 6 6 6 0 HEAT repeat zf-CCCH PF00642.24 EDP42643.1 - 9.9e-14 50.8 16.9 2.7e-08 33.5 1.2 4.4 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP42643.1 - 6.3e-13 48.3 23.3 2.3e-06 27.5 2.3 4.4 4 0 0 4 4 4 3 Zinc finger domain zf-CCCH_4 PF18044.1 EDP42643.1 - 0.0024 17.6 1.4 0.0024 17.6 1.4 4.7 6 0 0 6 6 6 3 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDP42643.1 - 0.0044 17.2 12.2 2.8 8.2 1.7 3.5 2 1 1 3 3 3 3 Zinc-finger containing family Torus PF16131.5 EDP42643.1 - 0.005 17.5 17.4 0.027 15.2 0.3 4.0 2 1 2 4 4 4 1 Torus domain zf-C3H1 PF10650.9 EDP42643.1 - 0.27 11.0 0.1 0.27 11.0 0.1 2.6 3 0 0 3 3 3 0 Putative zinc-finger domain RecQ_Zn_bind PF16124.5 EDP42643.1 - 2.7 8.8 6.4 2 9.2 3.5 2.4 2 0 0 2 2 2 0 RecQ zinc-binding PPP4R2 PF09184.11 EDP42643.1 - 4.5 6.8 8.5 8 6.0 8.5 1.4 1 0 0 1 1 1 0 PPP4R2 zf-CCCH_2 PF14608.6 EDP42643.1 - 6.3 7.4 22.1 0.44 11.1 0.7 4.2 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Rtf2 PF04641.12 EDP42644.1 - 2.6e-32 112.2 0.0 1.6e-30 106.4 0.0 2.0 1 1 0 1 1 1 1 Rtf2 RING-finger TRAF6_Z2 PF18048.1 EDP42644.1 - 0.055 13.6 1.1 0.055 13.6 1.1 1.6 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 S1 PF00575.23 EDP42645.1 - 3.3e-13 49.8 0.0 6.4e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 EDP42645.1 - 5.8e-10 39.4 0.0 1.1e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GCV_T PF01571.21 EDP42645.1 - 0.011 15.1 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain RNA_pol_Rbc25 PF08292.12 EDP42645.1 - 0.057 13.6 0.0 0.085 13.1 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Pkinase PF00069.25 EDP42647.1 - 7.6e-33 114.0 0.0 1e-32 113.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42647.1 - 2e-13 50.2 0.0 2.9e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP42647.1 - 0.0052 16.7 0.4 0.034 14.1 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP42647.1 - 0.0073 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDP42647.1 - 0.01 15.5 0.0 0.037 13.6 0.0 1.8 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EDP42647.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Glyco_transf_20 PF00982.21 EDP42648.1 - 2.2e-150 501.5 0.0 3.1e-150 501.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDP42648.1 - 9.6e-16 57.6 0.0 2.1e-15 56.5 0.0 1.6 1 1 0 1 1 1 1 Trehalose-phosphatase CEP1-DNA_bind PF09287.10 EDP42648.1 - 0.0041 16.8 0.0 0.0074 16.0 0.0 1.3 1 0 0 1 1 1 1 CEP-1, DNA binding Ldt_C PF17969.1 EDP42648.1 - 0.16 12.8 0.4 0.65 10.8 0.4 2.0 1 0 0 1 1 1 0 L,D-transpeptidase C-terminal domain P16-Arc PF04699.14 EDP42649.1 - 2.4e-48 164.4 0.0 2.7e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Pkinase PF00069.25 EDP42650.1 - 1.9e-72 243.8 0.1 2.8e-72 243.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42650.1 - 2.8e-52 177.6 0.1 5.2e-52 176.7 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDP42650.1 - 1.2e-22 80.0 0.0 2.7e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 EDP42650.1 - 3.9e-11 43.4 0.6 7.8e-11 42.4 0.6 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EDP42650.1 - 3.2e-06 26.7 0.0 6e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDP42650.1 - 4.7e-06 25.6 0.1 4.7e-06 25.6 0.1 1.8 2 1 0 2 2 2 1 Fungal protein kinase PH_11 PF15413.6 EDP42650.1 - 0.00021 21.7 2.0 0.025 15.0 2.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Haspin_kinase PF12330.8 EDP42650.1 - 0.0011 18.0 0.2 0.0022 17.0 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP42650.1 - 0.046 13.7 0.1 0.046 13.7 0.1 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family PH_9 PF15410.6 EDP42650.1 - 0.13 12.7 0.7 6.9 7.1 0.7 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain DUF1491 PF07372.12 EDP42650.1 - 0.28 11.6 0.8 1.5 9.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1491) RRM_1 PF00076.22 EDP42651.1 - 1.2e-22 79.5 0.0 4.7e-14 51.9 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP42651.1 - 0.1 12.7 0.0 0.67 10.1 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif FF PF01846.19 EDP42652.1 - 5.6e-30 103.3 0.8 5.7e-12 45.6 0.0 5.6 5 0 0 5 5 5 3 FF domain WW PF00397.26 EDP42652.1 - 4.9e-05 23.3 4.6 4.9e-05 23.3 4.6 2.2 2 0 0 2 2 2 1 WW domain RhoGAP-FF1 PF16512.5 EDP42652.1 - 0.015 16.0 3.0 1.1 10.0 0.3 3.6 3 0 0 3 3 3 0 p190-A and -B Rho GAPs FF domain LUD_dom PF02589.15 EDP42652.1 - 0.017 14.8 0.4 0.067 12.9 0.1 2.2 2 0 0 2 2 2 0 LUD domain HSP70 PF00012.20 EDP42653.1 - 5.4e-71 239.5 0.0 8.3e-71 238.9 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDP42653.1 - 2.4e-06 26.6 0.0 0.00061 18.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 EDP42653.1 - 0.0032 16.6 0.0 2.2 7.2 0.0 2.3 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; Guanylate_kin PF00625.21 EDP42654.1 - 1.5e-55 187.7 0.0 1.7e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EDP42654.1 - 6.1e-06 26.7 0.1 1.7e-05 25.2 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDP42654.1 - 7.7e-06 26.2 0.0 1.6e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EDP42654.1 - 8.9e-06 25.7 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EDP42654.1 - 1.1e-05 25.4 0.0 2.4e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EDP42654.1 - 1.6e-05 25.1 0.0 0.00014 22.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP42654.1 - 2.5e-05 24.8 0.0 6.2e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDP42654.1 - 7e-05 22.4 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EDP42654.1 - 0.00087 19.7 0.0 0.0022 18.4 0.0 1.7 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.27 EDP42654.1 - 0.0011 19.4 0.0 0.002 18.7 0.0 1.3 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 EDP42654.1 - 0.0015 18.8 0.0 0.073 13.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDP42654.1 - 0.0026 17.5 0.0 0.044 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EDP42654.1 - 0.0039 17.1 0.0 0.0052 16.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 EDP42654.1 - 0.0066 16.9 0.0 0.0098 16.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EDP42654.1 - 0.008 16.4 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EDP42654.1 - 0.0081 16.1 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EDP42654.1 - 0.01 15.8 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 EDP42654.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 EDP42654.1 - 0.021 14.7 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 NTPase Septin PF00735.18 EDP42654.1 - 0.026 13.8 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_14 PF13173.6 EDP42654.1 - 0.036 14.1 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDP42654.1 - 0.052 12.7 0.0 0.098 11.8 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 EDP42654.1 - 0.054 13.5 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDP42654.1 - 0.059 12.7 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDP42654.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 EDP42654.1 - 0.11 11.7 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CENP-T_C PF15511.6 EDP42655.1 - 8.9e-08 32.2 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EDP42655.1 - 0.00053 20.1 0.1 0.00079 19.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EDP42655.1 - 0.00088 19.6 0.0 0.0014 19.0 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EDP42655.1 - 0.00091 19.5 0.0 0.0017 18.6 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP42655.1 - 0.0012 19.3 0.1 0.0016 18.8 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EDP42655.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Nup35_RRM PF05172.13 EDP42656.1 - 2.7e-09 36.9 0.0 5.6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Glyco_hydro_42M PF08532.10 EDP42656.1 - 0.18 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Beta-galactosidase trimerisation domain Pkinase PF00069.25 EDP42657.1 - 2e-72 243.7 0.0 2.3e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42657.1 - 2.9e-32 112.0 0.0 3.6e-32 111.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP42657.1 - 0.00037 19.6 0.0 0.002 17.1 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP42657.1 - 0.00081 19.4 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP42657.1 - 0.0017 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EDP42657.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EDP42657.1 - 0.028 13.8 0.2 0.078 12.3 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tim17 PF02466.19 EDP42658.1 - 3.7e-09 36.9 0.1 5.3e-09 36.4 0.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HAD_2 PF13419.6 EDP42660.1 - 3.3e-14 53.4 0.0 4.6e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EDP42660.1 - 1.5e-09 38.5 0.0 1.5e-08 35.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EDP42660.1 - 0.00099 19.2 0.0 0.86 9.7 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EDP42660.1 - 0.0035 17.8 0.0 0.0077 16.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NT5C PF06941.12 EDP42660.1 - 0.065 13.1 0.0 2.8 7.8 0.0 2.2 2 0 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Snf7 PF03357.21 EDP42661.1 - 2.5e-42 144.4 18.1 3e-42 144.2 18.1 1.0 1 0 0 1 1 1 1 Snf7 Uso1_p115_C PF04871.13 EDP42661.1 - 0.0072 16.7 8.9 0.0072 16.7 8.9 2.7 1 1 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region Endotoxin_N PF03945.14 EDP42661.1 - 0.0079 15.9 4.4 0.47 10.1 3.5 2.1 1 1 1 2 2 2 1 delta endotoxin, N-terminal domain Phosphoprotein PF00922.17 EDP42661.1 - 0.041 13.5 4.0 0.068 12.8 4.0 1.3 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Glutaredoxin PF00462.24 EDP42661.1 - 0.11 12.7 0.1 0.59 10.4 0.1 2.2 1 0 0 1 1 1 0 Glutaredoxin Hpt PF01627.23 EDP42661.1 - 0.2 12.0 4.3 0.74 10.1 4.3 2.1 1 1 0 1 1 1 0 Hpt domain NPV_P10 PF05531.12 EDP42661.1 - 0.3 11.6 8.6 0.33 11.5 2.8 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EDP42661.1 - 0.48 11.0 18.1 2.5 8.6 15.2 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF5082 PF16888.5 EDP42661.1 - 0.86 9.9 13.7 49 4.2 11.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) AATF-Che1 PF13339.6 EDP42661.1 - 1.4 9.6 9.5 3.1 8.5 6.1 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Mgr1 PF08602.10 EDP42661.1 - 1.4 7.7 6.1 2.1 7.1 6.1 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit AAA_23 PF13476.6 EDP42661.1 - 1.6 9.2 6.9 2 8.9 6.9 1.1 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 EDP42661.1 - 3.2 6.3 10.2 4.5 5.8 8.1 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 EDP42661.1 - 9 6.6 18.7 4.6 7.6 9.8 3.5 2 2 2 4 4 4 0 ABC transporter C-terminal domain BAR PF03114.18 EDP42662.1 - 3.6e-43 147.9 0.1 4.7e-43 147.6 0.1 1.1 1 0 0 1 1 1 1 BAR domain DUF826 PF05696.11 EDP42662.1 - 0.045 13.8 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF826) Metallophos PF00149.28 EDP42663.1 - 1.3e-26 94.3 0.0 3.5e-26 93.0 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EDP42663.1 - 3.9e-23 81.6 0.0 6.5e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 EDP42663.1 - 2.2e-18 65.2 1.3 4e-05 23.3 0.1 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDP42663.1 - 3.2e-13 48.7 2.4 0.0012 18.8 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDP42663.1 - 1.3e-12 47.1 0.8 6.5e-06 25.7 0.0 3.4 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.6 EDP42663.1 - 7.3e-09 35.2 0.7 0.063 13.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP42663.1 - 1.1e-08 34.9 0.5 0.0092 16.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42663.1 - 0.00011 22.8 1.2 0.0015 19.2 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42663.1 - 0.00023 21.6 3.8 0.11 13.0 0.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP42663.1 - 0.00046 20.8 2.0 2.6 9.1 0.2 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP42663.1 - 0.00079 19.7 2.1 1.4 9.3 0.3 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDP42663.1 - 0.012 15.7 0.3 0.47 10.6 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP42663.1 - 0.031 14.9 1.5 14 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42663.1 - 0.076 13.1 0.1 0.61 10.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF354 PF04007.12 EDP42663.1 - 0.23 10.5 0.0 0.66 9.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF354) Fis1_TPR_C PF14853.6 EDP42663.1 - 0.25 11.4 0.4 3.1 7.9 0.1 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Ribosomal_L21p PF00829.21 EDP42664.1 - 2.7e-17 62.8 0.0 1.4e-11 44.5 0.1 2.2 2 0 0 2 2 2 2 Ribosomal prokaryotic L21 protein ATP-synt_ab PF00006.25 EDP42665.1 - 5.5e-71 238.6 0.0 8.3e-71 238.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EDP42665.1 - 6.5e-41 139.6 0.0 1.2e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EDP42665.1 - 2e-19 69.9 2.3 3e-19 69.3 1.3 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 EDP42665.1 - 0.0067 16.6 1.0 0.013 15.6 1.0 1.5 1 0 0 1 1 1 1 HAS barrel domain NPM1-C PF16276.5 EDP42665.1 - 0.056 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nucleophosmin C-terminal domain Dynamin_M PF01031.20 EDP42666.1 - 2.4e-106 355.2 0.0 1.2e-105 352.8 0.0 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EDP42666.1 - 9.8e-35 120.1 0.0 2.2e-34 118.9 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EDP42666.1 - 1.4e-27 95.6 2.7 1.4e-27 95.6 2.7 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain TipAS PF07739.13 EDP42666.1 - 0.04 14.5 0.1 0.15 12.7 0.0 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Sas10_Utp3 PF04000.15 EDP42667.1 - 8.4e-13 48.8 0.5 2.4e-12 47.3 0.5 1.8 1 0 0 1 1 1 1 Sas10/Utp3/C1D family FAM219A PF15260.6 EDP42667.1 - 0.7 10.3 3.5 1.3 9.4 0.3 2.5 3 0 0 3 3 3 0 Protein family FAM219A MBOAT PF03062.19 EDP42668.1 - 1.5e-36 126.5 18.8 4.5e-36 124.9 18.8 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF4658 PF15555.6 EDP42668.1 - 0.1 12.7 0.3 0.21 11.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) MBOAT_2 PF13813.6 EDP42668.1 - 0.12 12.7 6.4 0.063 13.6 3.7 1.9 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family UAA PF08449.11 EDP42669.1 - 1e-81 274.5 14.3 1.2e-81 274.3 14.3 1.0 1 0 0 1 1 1 1 UAA transporter family RasGEF PF00617.19 EDP42671.1 - 3.9e-41 141.2 0.3 8.5e-41 140.1 0.3 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDP42671.1 - 1.7e-05 25.0 0.0 4.1e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif TPR_11 PF13414.6 EDP42671.1 - 0.21 11.3 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 TPR repeat SRF-TF PF00319.18 EDP42672.1 - 1.3e-20 72.6 0.1 1.9e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Sortilin-Vps10 PF15902.5 EDP42673.1 - 9.9e-241 799.1 0.0 7.1e-128 427.2 0.0 2.8 3 1 0 3 3 3 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EDP42673.1 - 3.4e-83 278.1 3.3 1.7e-44 152.1 0.0 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EDP42673.1 - 4.8e-10 37.9 34.3 3.3 8.1 0.6 11.4 11 0 0 11 11 11 5 BNR/Asp-box repeat CHB_HEX_C PF03174.13 EDP42673.1 - 0.00099 19.0 0.9 15 5.6 0.0 5.6 5 1 1 6 6 6 1 Chitobiase/beta-hexosaminidase C-terminal domain PSII_BNR PF14870.6 EDP42673.1 - 0.0015 17.8 0.3 0.68 9.1 0.1 4.1 3 0 0 3 3 3 1 Photosynthesis system II assembly factor YCF48 preSET_CXC PF18264.1 EDP42673.1 - 4.1 8.0 7.4 9.4 6.8 1.0 2.8 2 0 0 2 2 2 0 CXC domain DUF3169 PF11368.8 EDP42674.1 - 0.051 13.1 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF2721 PF11026.8 EDP42674.1 - 5.1 7.0 5.7 1.8 8.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Dus PF01207.17 EDP42675.1 - 4.3e-40 137.7 0.0 1.7e-27 96.3 0.0 2.0 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) ScsC_N PF18312.1 EDP42675.1 - 0.19 11.6 0.1 0.49 10.2 0.1 1.6 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain ASF1_hist_chap PF04729.13 EDP42676.1 - 2.4e-70 235.4 0.1 3.1e-70 235.1 0.1 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone Sterol_MT_C PF08498.10 EDP42677.1 - 1.3e-30 105.5 0.7 2e-30 104.9 0.7 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EDP42677.1 - 1.5e-18 67.2 0.0 3.1e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP42677.1 - 1.8e-16 60.6 0.0 4.7e-16 59.3 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42677.1 - 1.8e-16 60.3 0.0 2.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP42677.1 - 3.4e-14 53.0 0.0 5.1e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDP42677.1 - 1.4e-13 50.8 0.0 1.8e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDP42677.1 - 7.9e-11 42.6 0.1 2.5e-10 41.0 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDP42677.1 - 1.6e-06 27.6 0.0 3.8e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EDP42677.1 - 2.9e-05 23.9 0.0 4e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EDP42677.1 - 0.00025 20.6 0.0 0.00046 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EDP42677.1 - 0.0017 18.4 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EDP42677.1 - 0.0037 16.9 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_3 PF01596.17 EDP42677.1 - 0.0047 16.1 0.0 0.0073 15.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_15 PF09445.10 EDP42677.1 - 0.0054 16.3 0.0 0.0079 15.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_2 PF00891.18 EDP42677.1 - 0.016 14.5 0.1 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_24 PF13578.6 EDP42677.1 - 0.034 15.2 0.0 0.2 12.7 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain UPF0020 PF01170.18 EDP42677.1 - 0.045 13.4 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 EDP42677.1 - 0.095 12.2 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 EDP42677.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EDP42677.1 - 0.19 11.9 0.0 0.55 10.3 0.0 1.7 2 0 0 2 2 2 0 FtsJ-like methyltransferase DHO_dh PF01180.21 EDP42678.1 - 4.5e-98 328.1 0.0 6.2e-98 327.6 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 EDP42678.1 - 0.0046 16.4 0.2 0.0078 15.6 0.2 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 EDP42678.1 - 0.0082 15.2 0.8 0.22 10.5 1.0 2.5 2 1 0 2 2 2 1 FMN-dependent dehydrogenase CR6_interact PF10147.9 EDP42678.1 - 0.16 11.7 0.1 0.44 10.2 0.2 1.6 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 zf-C2H2 PF00096.26 EDP42679.1 - 4.7e-22 77.1 23.4 1.3e-05 25.3 1.6 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDP42679.1 - 6.4e-22 77.0 19.4 5.3e-06 26.6 0.1 5.4 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDP42679.1 - 2.7e-12 46.4 21.4 0.0073 17.0 1.4 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDP42679.1 - 9.5e-06 25.8 4.1 0.13 12.6 0.1 3.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDP42679.1 - 0.00017 21.9 10.2 0.022 15.2 0.3 3.8 4 0 0 4 4 4 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EDP42679.1 - 0.00078 20.0 1.3 2.7 8.7 0.0 3.4 1 1 2 3 3 3 1 FOXP coiled-coil domain ADK_lid PF05191.14 EDP42679.1 - 0.058 13.4 0.3 4.4 7.4 0.1 3.7 3 1 0 3 3 3 0 Adenylate kinase, active site lid zf-TRAF PF02176.18 EDP42679.1 - 0.078 13.7 9.2 0.2 12.3 0.5 3.1 2 1 1 3 3 3 0 TRAF-type zinc finger Viral_helicase1 PF01443.18 EDP42679.1 - 0.084 12.6 0.1 10 5.8 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase zf-C2H2_aberr PF17017.5 EDP42679.1 - 0.19 11.8 1.9 33 4.5 0.0 3.0 1 1 2 3 3 3 0 Aberrant zinc-finger zf-MYST PF17772.1 EDP42679.1 - 0.32 10.6 1.9 1.3 8.7 0.0 2.9 4 0 0 4 4 4 0 MYST family zinc finger domain zf-C2H2_6 PF13912.6 EDP42679.1 - 0.64 10.1 13.3 0.21 11.6 0.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDP42679.1 - 0.73 9.6 14.5 2.5 7.9 1.4 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EDP42679.1 - 2.5 8.0 14.5 15 5.4 0.2 4.4 4 0 0 4 4 4 0 C2H2-type zinc-finger domain SMC_N PF02463.19 EDP42680.1 - 4.1e-72 242.2 0.0 6.9e-72 241.4 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EDP42680.1 - 3.8e-25 88.5 0.0 1e-24 87.0 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EDP42680.1 - 3.9e-14 53.2 6.0 7.5e-07 29.3 0.1 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDP42680.1 - 2.4e-10 41.2 0.0 2.4e-10 41.2 0.0 6.1 2 2 0 4 4 1 1 AAA domain AAA_29 PF13555.6 EDP42680.1 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EDP42680.1 - 0.00049 19.9 0.0 0.00049 19.9 0.0 3.4 3 1 1 4 4 3 1 AAA ATPase domain SbcCD_C PF13558.6 EDP42680.1 - 0.0055 16.9 0.0 0.39 11.0 0.0 2.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit PKcGMP_CC PF16808.5 EDP42680.1 - 0.01 15.7 1.2 0.01 15.7 1.2 4.1 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase 7tm_6 PF02949.20 EDP42680.1 - 0.081 12.0 0.6 0.23 10.5 0.6 1.7 1 0 0 1 1 1 0 7tm Odorant receptor ABC_tran PF00005.27 EDP42680.1 - 0.3 11.6 0.0 0.3 11.6 0.0 4.9 4 2 1 5 5 4 0 ABC transporter Baculo_PEP_C PF04513.12 EDP42680.1 - 2.2 8.3 17.2 0.055 13.5 2.5 4.3 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_22 PF13401.6 EDP42680.1 - 5.5 7.3 15.7 18 5.6 0.0 5.3 5 0 0 5 5 5 0 AAA domain Ipi1_N PF12333.8 EDP42681.1 - 0.08 13.5 0.0 0.096 13.3 0.0 1.2 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DUF2277 PF10041.9 EDP42681.1 - 0.18 12.2 0.1 0.36 11.2 0.1 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) DUF2418 PF10332.9 EDP42682.1 - 1.6e-13 51.0 0.0 1.8e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) MCM_bind PF09739.9 EDP42683.1 - 5.1e-85 286.1 0.0 6.3e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor MCM_lid PF17855.1 EDP42683.1 - 0.025 15.0 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 MCM AAA-lid domain CKS PF01111.19 EDP42684.1 - 6.4e-35 119.3 0.3 8.6e-35 118.8 0.3 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Aldo_ket_red PF00248.21 EDP42685.1 - 1e-48 166.1 0.1 7.1e-47 160.0 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Molydop_binding PF01568.21 EDP42685.1 - 0.063 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Aldo_ket_red PF00248.21 EDP42686.1 - 3.6e-47 161.0 0.0 6e-46 157.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 EDP42687.1 - 4.4e-47 160.7 0.0 1.5e-45 155.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family nsp8 PF08717.10 EDP42687.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 nsp8 replicase HGTP_anticodon PF03129.20 EDP42688.1 - 4.3e-20 71.7 0.0 9.7e-20 70.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EDP42688.1 - 2.7e-09 37.2 0.0 6.1e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sds3 PF08598.11 EDP42689.1 - 0.0047 16.9 18.8 0.0047 16.9 18.8 12.7 3 1 6 10 10 10 5 Sds3-like Mcp5_PH PF12814.7 EDP42690.1 - 1.2e-39 135.2 0.1 3.2e-39 133.8 0.1 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EDP42690.1 - 0.075 13.5 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 PH domain DUF4709 PF15821.5 EDP42690.1 - 3.6 7.9 10.4 0.22 11.8 1.2 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4709) Baculo_PEP_C PF04513.12 EDP42690.1 - 8.5 6.4 17.6 0.56 10.3 2.1 3.7 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nop10p PF04135.12 EDP42691.1 - 2.7e-21 75.3 0.5 3.2e-21 75.1 0.5 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family EMP24_GP25L PF01105.24 EDP42692.1 - 8.3e-32 110.6 0.0 9.5e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Integrin_alpha PF00357.20 EDP42692.1 - 0.58 10.3 1.9 1.2 9.2 1.9 1.5 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region zf-UBR PF02207.20 EDP42693.1 - 1.7e-10 40.9 9.1 1.7e-10 40.9 9.1 3.5 3 1 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.29 EDP42693.1 - 0.00064 19.6 9.0 0.00064 19.6 9.0 3.6 3 2 0 3 3 3 1 PHD-finger C1_1 PF00130.22 EDP42693.1 - 0.023 14.6 1.6 0.023 14.6 1.6 4.7 4 1 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EDP42693.1 - 3.8 7.7 10.2 0.12 12.5 2.3 2.7 2 1 0 2 2 2 0 KIAA1045 RING finger Pyrid_oxidase_2 PF13883.6 EDP42694.1 - 6e-19 68.6 0.1 7.3e-19 68.4 0.1 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase VRR_NUC PF08774.11 EDP42695.1 - 5.2e-17 61.9 0.0 2.2e-16 59.9 0.0 2.0 2 0 0 2 2 2 1 VRR-NUC domain SAP PF02037.27 EDP42695.1 - 0.00099 18.8 0.7 0.0022 17.7 0.7 1.6 1 0 0 1 1 1 1 SAP domain Pox_A_type_inc PF04508.12 EDP42695.1 - 0.73 9.8 3.0 1.5 8.8 0.1 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Myosin_head PF00063.21 EDP42697.1 - 1e-262 873.3 0.0 1e-262 873.3 0.0 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 EDP42697.1 - 1.2e-06 28.3 0.3 2.3e-06 27.3 0.3 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 EDP42697.1 - 0.28 11.5 0.0 0.28 11.5 0.0 4.1 4 1 0 4 4 4 0 AAA domain DUF1366 PF07104.11 EDP42697.1 - 1.9 8.2 9.1 0.1 12.3 2.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) MOZ_SAS PF01853.18 EDP42698.1 - 1.3e-15 57.6 0.0 1.8e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family DUF1456 PF07308.13 EDP42698.1 - 0.18 12.2 0.0 3.1 8.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1456) WD40 PF00400.32 EDP42699.1 - 3.4e-61 201.7 23.3 5.6e-11 42.8 0.1 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42699.1 - 2e-21 76.1 2.8 1.6e-06 28.3 0.1 5.1 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP42699.1 - 2.5e-12 46.2 6.0 4.7e-05 22.2 0.1 4.4 2 1 1 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EDP42699.1 - 2.6e-05 23.1 1.5 0.21 10.3 0.0 3.5 1 1 2 4 4 4 3 Nup133 N terminal like WD40_like PF17005.5 EDP42699.1 - 0.056 12.8 0.0 1.7 7.9 0.0 2.8 3 1 1 4 4 4 0 WD40-like domain Kinesin PF00225.23 EDP42700.1 - 7e-77 258.6 1.5 1.4e-42 145.8 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EDP42700.1 - 0.00032 20.7 0.0 0.00084 19.3 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding DUF16 PF01519.16 EDP42700.1 - 0.00079 19.9 5.7 0.00087 19.7 1.3 2.6 2 0 0 2 2 2 1 Protein of unknown function DUF16 FPP PF05911.11 EDP42700.1 - 0.0017 16.7 8.3 0.0025 16.1 8.3 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Mod_r PF07200.13 EDP42700.1 - 0.018 15.1 0.9 0.018 15.1 0.9 2.8 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein UPF0242 PF06785.11 EDP42700.1 - 0.089 12.9 9.6 1.1 9.4 0.9 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 EDP42700.1 - 0.28 11.4 20.2 0.11 12.7 9.9 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 EDP42700.1 - 0.38 11.2 3.1 21 5.6 0.2 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EDP42700.1 - 0.44 9.9 3.7 0.76 9.1 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.9 EDP42700.1 - 0.47 10.8 6.0 0.16 12.2 1.0 2.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PI3K_P85_iSH2 PF16454.5 EDP42700.1 - 0.6 9.7 8.0 0.087 12.4 3.3 1.9 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Snapin_Pallidin PF14712.6 EDP42700.1 - 2.2 8.8 9.2 0.28 11.6 1.0 2.9 3 1 1 4 4 4 0 Snapin/Pallidin Lebercilin PF15619.6 EDP42700.1 - 2.4 7.8 14.3 0.029 14.0 2.2 2.8 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease BRE1 PF08647.11 EDP42700.1 - 4.5 7.4 9.5 0.22 11.6 0.5 2.8 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 EDP42700.1 - 6.5 6.0 10.1 0.18 11.2 1.6 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.20 EDP42700.1 - 8.6 5.7 14.3 5 6.4 10.0 2.1 1 1 1 2 2 2 0 Tropomyosin DAHP_synth_1 PF00793.20 EDP42701.1 - 2.6e-93 311.9 0.0 3e-93 311.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family DUF3692 PF12469.8 EDP42701.1 - 0.18 12.0 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein CBFD_NFYB_HMF PF00808.23 EDP42702.1 - 1.1e-18 67.2 0.1 1.9e-18 66.5 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YolD PF08863.10 EDP42702.1 - 0.01 15.8 2.2 1 9.4 0.8 2.1 2 0 0 2 2 2 0 YolD-like protein FTHFS PF01268.19 EDP42703.1 - 5e-254 843.6 0.0 6.2e-253 840.0 0.0 2.0 2 0 0 2 2 2 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EDP42703.1 - 2.6e-60 202.4 3.0 7.6e-60 200.8 1.6 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EDP42703.1 - 1.2e-18 67.5 0.1 3.1e-18 66.1 0.1 1.8 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SAM_2 PF07647.17 EDP42704.1 - 2.6e-08 33.9 1.5 3.4e-08 33.5 0.0 2.0 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EDP42704.1 - 4.7e-05 23.7 0.0 0.0001 22.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) NRBF2 PF08961.10 EDP42704.1 - 0.089 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator IGR PF09597.10 EDP42704.1 - 0.096 12.8 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 IGR protein motif DUF4407 PF14362.6 EDP42704.1 - 9.1 5.5 7.5 17 4.6 6.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ATP-synt_ab PF00006.25 EDP42706.1 - 1.7e-63 214.1 0.0 2.6e-63 213.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EDP42706.1 - 2.3e-14 53.6 0.7 1e-13 51.6 0.6 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_16 PF13191.6 EDP42706.1 - 0.0063 16.9 0.0 0.017 15.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EDP42706.1 - 0.0068 15.6 0.9 0.012 14.8 0.2 1.7 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 EDP42706.1 - 0.011 15.7 0.1 0.025 14.5 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 EDP42706.1 - 0.017 15.6 0.0 0.23 11.9 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDP42706.1 - 0.026 14.4 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 EDP42706.1 - 0.029 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EDP42706.1 - 0.048 13.0 0.3 0.097 12.0 0.3 1.5 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 EDP42706.1 - 0.054 13.8 0.8 0.22 11.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDP42706.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Septin PF00735.18 EDP42707.1 - 3.4e-82 275.9 3.1 6.4e-69 232.3 0.4 2.0 1 1 1 2 2 2 2 Septin RsgA_GTPase PF03193.16 EDP42707.1 - 2.5e-05 24.3 1.0 0.00099 19.0 0.4 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EDP42707.1 - 5.2e-05 23.5 0.1 0.0026 18.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EDP42707.1 - 0.00012 22.2 0.5 0.00061 19.9 0.3 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EDP42707.1 - 0.0019 17.6 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 EDP42707.1 - 0.0061 17.0 0.0 0.0097 16.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EDP42707.1 - 0.0062 17.0 0.0 0.014 15.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AIG1 PF04548.16 EDP42707.1 - 0.0083 15.5 0.3 0.0083 15.5 0.3 2.1 3 0 0 3 3 3 1 AIG1 family AAA_7 PF12775.7 EDP42707.1 - 0.01 15.4 0.4 0.019 14.5 0.2 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EDP42707.1 - 0.011 15.8 0.1 0.024 14.7 0.1 1.6 1 0 0 1 1 1 0 Dynamin family IIGP PF05049.13 EDP42707.1 - 0.019 14.1 0.3 0.045 12.8 0.0 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) NB-ARC PF00931.22 EDP42707.1 - 0.02 14.1 0.1 0.028 13.6 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain RuvB_N PF05496.12 EDP42707.1 - 0.024 14.4 0.1 2.3 7.9 0.0 2.4 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain GTP_EFTU PF00009.27 EDP42707.1 - 0.03 13.9 0.1 5.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 EDP42707.1 - 0.031 13.7 0.0 0.052 13.0 0.0 1.4 1 1 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EDP42707.1 - 0.046 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SCAMP PF04144.13 EDP42708.1 - 2.7e-47 161.3 13.3 3.2e-47 161.1 13.3 1.1 1 0 0 1 1 1 1 SCAMP family Peptidase_U4 PF03419.13 EDP42708.1 - 3.5 6.8 11.8 4.6 6.4 11.8 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Bromodomain PF00439.25 EDP42709.1 - 4.5e-40 135.6 1.5 5e-19 68.2 0.1 2.3 2 0 0 2 2 2 2 Bromodomain CENP-S PF15630.6 EDP42709.1 - 0.025 15.0 0.5 0.38 11.2 0.1 2.3 2 0 0 2 2 2 0 CENP-S protein Sec39 PF08314.11 EDP42710.1 - 4.8e-17 61.7 0.0 1.3e-16 60.3 0.0 1.6 2 0 0 2 2 2 1 Secretory pathway protein Sec39 DUF3419 PF11899.8 EDP42711.1 - 5.4e-145 483.4 0.1 1.1e-144 482.4 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3419) Methyltransf_25 PF13649.6 EDP42711.1 - 1.1e-08 35.7 0.0 9e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42711.1 - 3.4e-07 30.2 0.0 9.2e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP42711.1 - 1.4e-06 28.3 0.0 3.7e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EDP42711.1 - 2.4e-06 27.1 0.0 1.5e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EDP42711.1 - 3.7e-06 27.6 0.0 1.2e-05 25.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP42711.1 - 3.8e-06 27.5 0.0 6.1e-05 23.6 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_4 PF02390.17 EDP42711.1 - 0.028 13.9 0.0 0.063 12.7 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Hs1pro-1_C PF07014.12 EDP42711.1 - 0.07 12.6 0.0 5.2 6.5 0.0 2.4 3 0 0 3 3 3 0 Hs1pro-1 protein C-terminus Adaptin_N PF01602.20 EDP42712.1 - 2.8e-89 300.1 10.7 5.4e-89 299.1 10.7 1.4 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDP42712.1 - 3.8e-10 40.0 6.0 1e-08 35.4 0.4 4.1 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EDP42712.1 - 0.00029 20.9 3.4 16 6.1 0.1 5.4 4 0 0 4 4 4 1 HEAT repeat MMS19_N PF14500.6 EDP42712.1 - 0.08 12.5 1.7 0.76 9.3 0.2 2.7 1 1 1 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II APAF1_C PF17908.1 EDP42712.1 - 0.25 11.3 1.9 14 5.7 0.1 3.3 2 1 1 3 3 3 0 APAF-1 helical domain Tim54 PF11711.8 EDP42715.1 - 9.2e-47 159.6 0.0 1.8e-46 158.6 0.0 1.4 1 1 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF3123 PF11321.8 EDP42715.1 - 1.8 9.2 5.0 36 5.1 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3123) PNP_UDP_1 PF01048.20 EDP42716.1 - 1.1e-35 123.0 0.2 1.3e-35 122.8 0.2 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily mRNA_triPase PF02940.15 EDP42717.1 - 2.1e-35 122.4 0.8 2.5e-35 122.2 0.8 1.0 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Pkinase PF00069.25 EDP42718.1 - 3e-55 187.4 0.0 4.3e-55 186.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42718.1 - 1e-30 106.9 0.0 1.5e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP42718.1 - 0.0056 16.0 0.2 2.2 7.5 0.3 2.5 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 EDP42718.1 - 0.0066 15.8 0.2 0.012 15.0 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MutS_V PF00488.21 EDP42719.1 - 1.2e-66 224.4 0.2 2.1e-66 223.6 0.2 1.4 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EDP42719.1 - 2.6e-35 121.1 0.0 1.8e-34 118.4 0.0 2.3 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 EDP42719.1 - 1.7e-30 106.7 0.1 4.6e-30 105.3 0.1 1.8 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 EDP42719.1 - 9.7e-13 48.6 0.0 2.2e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EDP42719.1 - 8e-08 32.5 0.0 2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV Nop14 PF04147.12 EDP42719.1 - 1.6 6.8 12.2 2.5 6.2 12.2 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EDP42719.1 - 2.5 7.5 13.7 4.2 6.7 13.7 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EDP42719.1 - 2.7 6.2 12.5 4.6 5.4 12.5 1.2 1 0 0 1 1 1 0 CDC45-like protein FAT PF02259.23 EDP42720.1 - 2.9e-114 381.9 0.2 2.9e-114 381.9 0.2 1.9 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EDP42720.1 - 1.5e-67 228.1 0.0 2.5e-67 227.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EDP42720.1 - 2.4e-59 199.9 0.7 2.5e-57 193.3 0.0 4.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EDP42720.1 - 2.4e-43 146.6 0.3 2.4e-43 146.6 0.3 3.2 3 0 0 3 3 2 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EDP42720.1 - 4e-16 59.2 22.6 0.00087 19.6 0.0 10.5 8 1 3 11 11 11 5 HEAT repeats FATC PF02260.20 EDP42720.1 - 2.6e-15 55.9 0.7 1.8e-14 53.2 0.3 2.7 2 0 0 2 2 2 1 FATC domain HEAT PF02985.22 EDP42720.1 - 4.5e-13 48.2 15.6 0.033 14.4 0.1 11.1 9 0 0 9 9 9 2 HEAT repeat UME PF08064.13 EDP42720.1 - 3.5e-06 26.8 1.7 4.1 7.4 0.1 5.7 5 0 0 5 5 5 2 UME (NUC010) domain HEAT_EZ PF13513.6 EDP42720.1 - 0.00087 19.7 36.3 0.038 14.5 0.7 11.7 14 2 2 16 16 14 3 HEAT-like repeat Cnd1 PF12717.7 EDP42720.1 - 0.0014 18.7 1.0 3.5 7.6 0.1 4.5 3 1 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 TPR_19 PF14559.6 EDP42720.1 - 0.0022 18.5 0.2 7.6 7.1 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDP42720.1 - 0.0035 18.0 2.9 0.57 10.9 0.3 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Vac14_Fab1_bd PF12755.7 EDP42720.1 - 0.0054 17.3 3.4 1e+02 3.6 0.0 6.8 6 1 2 8 8 6 0 Vacuolar 14 Fab1-binding region HEAT_PBS PF03130.16 EDP42720.1 - 0.51 11.2 8.1 1.1e+02 3.9 0.5 7.1 6 1 0 6 6 5 0 PBS lyase HEAT-like repeat PFU PF09070.11 EDP42721.1 - 5.4e-36 123.3 0.0 8.5e-36 122.7 0.0 1.3 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 EDP42721.1 - 1.2e-31 110.0 0.4 1.7e-31 109.5 0.4 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 EDP42721.1 - 1.3e-18 67.0 23.4 0.00026 21.7 0.7 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 EDP42721.1 - 0.0002 21.4 0.0 0.31 11.1 0.0 3.3 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region PQ-loop PF04193.14 EDP42722.1 - 1e-17 63.6 8.4 1.8e-09 37.3 3.7 2.7 2 0 0 2 2 2 2 PQ loop repeat DUF5504 PF17608.2 EDP42722.1 - 0.37 10.9 4.7 0.83 9.8 0.7 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5504) Syndecan PF01034.20 EDP42722.1 - 2.1 8.3 0.0 2.1 8.3 0.0 3.3 3 0 0 3 3 3 0 Syndecan domain Herpes_LMP1 PF05297.11 EDP42722.1 - 3.3 6.8 16.0 1.7 7.8 0.3 2.1 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) YfhO PF09586.10 EDP42722.1 - 9.4 4.3 7.3 0.39 8.9 1.4 1.6 2 0 0 2 2 2 0 Bacterial membrane protein YfhO Endonuclease_NS PF01223.23 EDP42723.1 - 1.5e-53 181.9 0.0 2.1e-53 181.5 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Aminotran_3 PF00202.21 EDP42724.1 - 3.5e-122 408.0 0.0 4.1e-122 407.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDP42724.1 - 0.0032 16.7 0.0 0.0076 15.5 0.0 1.7 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EDP42724.1 - 0.044 13.1 0.0 0.12 11.6 0.0 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase Cyt-b5 PF00173.28 EDP42725.1 - 5.7e-13 48.8 0.0 9.6e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MHC2-interact PF09307.10 EDP42725.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 CLIP, MHC2 interacting Ribosomal_L7Ae PF01248.26 EDP42726.1 - 6e-13 48.3 0.0 1.3e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Eapp_C PF10238.9 EDP42726.1 - 0.023 14.8 0.9 0.031 14.3 0.9 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein Inhibitor_I34 PF10466.9 EDP42726.1 - 0.18 12.4 16.6 1.1 9.9 0.0 2.3 2 0 0 2 2 2 0 Saccharopepsin inhibitor I34 Sec62 PF03839.16 EDP42726.1 - 0.4 10.1 3.8 0.61 9.5 3.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 MscS_TM PF12794.7 EDP42726.1 - 0.66 8.8 1.2 0.9 8.3 1.2 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Zip PF02535.22 EDP42726.1 - 0.84 8.8 2.2 1.1 8.4 2.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.12 EDP42726.1 - 0.87 9.8 6.3 1.3 9.3 6.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family NARP1 PF12569.8 EDP42726.1 - 1.6 7.6 10.7 1.9 7.3 10.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PPL5 PF18168.1 EDP42726.1 - 1.7 7.9 6.1 2.4 7.4 6.1 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Cytomega_UL84 PF06284.11 EDP42726.1 - 2.5 6.4 5.5 3.9 5.8 5.5 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Connexin PF00029.19 EDP42726.1 - 3.4 7.4 4.3 4.4 7.0 4.3 1.2 1 0 0 1 1 1 0 Connexin OAD_gamma PF04277.13 EDP42726.1 - 3.4 8.3 7.0 1.4 9.6 4.5 1.7 2 0 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain Ferlin_C PF16165.5 EDP42726.1 - 3.7 7.5 7.2 6.6 6.7 7.2 1.5 1 0 0 1 1 1 0 Ferlin C-terminus DUF4775 PF16001.5 EDP42726.1 - 4.8 6.5 18.8 7.4 5.9 18.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Peptidase_S49_N PF08496.10 EDP42726.1 - 6.5 6.8 12.1 4.8 7.2 10.6 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal tRNA-synt_1b PF00579.25 EDP42727.1 - 1.3e-66 224.9 0.0 1.5e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Peroxin-13_N PF04088.13 EDP42728.1 - 1.1e-46 158.7 0.1 2.2e-46 157.7 0.1 1.5 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EDP42728.1 - 3.6e-12 45.8 0.0 5.9e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EDP42728.1 - 1.5e-10 40.5 0.0 2.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP42728.1 - 9e-10 38.3 0.0 1.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Arm-DNA-bind_3 PF13356.6 EDP42728.1 - 0.081 13.3 1.5 0.2 12.1 0.1 2.2 2 1 0 2 2 2 0 Arm DNA-binding domain Pex2_Pex12 PF04757.14 EDP42728.1 - 0.16 11.5 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region Ribosomal_L16 PF00252.18 EDP42729.1 - 6.2e-40 136.3 0.0 8e-40 135.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF3212 PF11486.8 EDP42729.1 - 0.096 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) Rep_fac-A_C PF08646.10 EDP42731.1 - 4.2e-51 172.5 0.0 1.3e-48 164.5 0.0 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EDP42731.1 - 2.2e-35 120.5 0.7 3.5e-34 116.6 0.2 2.7 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EDP42731.1 - 6e-12 45.4 0.1 6.7e-09 35.6 0.0 3.4 3 1 0 3 3 3 1 OB-fold nucleic acid binding domain Rep-A_N PF04057.12 EDP42731.1 - 1.7e-10 40.8 0.5 3.8e-10 39.7 0.5 1.7 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF4539 PF15072.6 EDP42731.1 - 0.029 14.4 0.0 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) PH PF00169.29 EDP42732.1 - 2.2e-08 34.6 0.0 0.0029 18.1 0.0 2.5 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EDP42732.1 - 4.4e-08 33.5 0.7 1.1e-06 29.0 0.7 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EDP42732.1 - 0.11 12.9 0.2 0.92 10.0 0.2 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain Ist1 PF03398.14 EDP42733.1 - 3.3e-51 173.5 2.8 4e-51 173.2 2.8 1.0 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DNA_primase_S PF01896.19 EDP42734.1 - 3.7e-50 170.4 0.0 7.2e-50 169.5 0.0 1.5 1 1 0 1 1 1 1 DNA primase small subunit zf-AD PF07776.15 EDP42734.1 - 0.051 13.8 0.8 16 5.8 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) Pyridoxal_deC PF00282.19 EDP42735.1 - 6.4e-57 193.0 0.0 5e-56 190.0 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EDP42735.1 - 0.021 13.8 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V OKR_DC_1 PF01276.20 EDP42735.1 - 0.027 13.2 0.0 0.039 12.7 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Pkinase PF00069.25 EDP42736.1 - 2.3e-72 243.5 0.1 3.3e-72 243.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42736.1 - 7.6e-43 146.7 0.0 1.3e-42 145.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EDP42736.1 - 6.9e-31 106.2 0.0 7.5e-16 58.1 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EDP42736.1 - 2.1e-06 27.3 0.0 9.7e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EDP42736.1 - 0.00045 19.1 0.0 0.00086 18.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EDP42736.1 - 0.0085 15.1 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain BRCA-2_OB1 PF09103.10 EDP42737.1 - 0.025 14.5 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_OB1 PF09103.10 EDP42738.1 - 1.3e-19 70.3 0.0 1.8e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 EDP42738.1 - 6.9e-06 25.9 0.8 1e-05 25.3 0.8 1.2 1 0 0 1 1 1 1 BRCA2, helical SIS PF01380.22 EDP42740.1 - 6.6e-63 210.4 0.2 3.4e-34 117.5 0.1 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EDP42740.1 - 4.4e-16 59.3 0.0 9.1e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDP42740.1 - 4.4e-11 42.8 0.0 8.5e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EDP42740.1 - 0.00091 18.2 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II YoeB_toxin PF06769.14 EDP42740.1 - 0.024 14.7 0.0 0.065 13.3 0.0 1.7 1 0 0 1 1 1 0 YoeB-like toxin of bacterial type II toxin-antitoxin system Helicase_C_2 PF13307.6 EDP42741.1 - 4.5e-53 179.9 0.0 1.3e-52 178.4 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EDP42741.1 - 1.4e-46 158.3 0.0 2.7e-46 157.4 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EDP42741.1 - 1.3e-05 25.2 0.4 0.17 11.9 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 EDP42741.1 - 0.0079 16.0 0.5 0.13 12.0 0.5 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 EDP42741.1 - 0.0092 15.5 0.1 0.053 13.0 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein DUF4691 PF15762.5 EDP42741.1 - 0.11 12.7 0.1 0.27 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) GRAB PF10375.9 EDP42743.1 - 6.2e-11 41.8 1.7 5.1e-09 35.7 0.1 2.4 2 0 0 2 2 2 2 GRIP-related Arf-binding domain GRIP PF01465.20 EDP42743.1 - 0.011 15.7 0.1 0.046 13.6 0.0 2.0 2 0 0 2 2 2 0 GRIP domain Ribosomal_S10 PF00338.22 EDP42744.1 - 6.9e-27 93.6 0.7 8.2e-27 93.3 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF3642 PF12182.8 EDP42744.1 - 0.027 14.8 0.0 0.042 14.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial lipoprotein Ribosomal_L27A PF00828.19 EDP42745.1 - 4.4e-20 72.7 0.0 7.5e-20 71.9 0.0 1.4 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A IBR PF01485.21 EDP42746.1 - 1.3e-18 66.9 46.2 7.6e-11 42.1 4.3 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EDP42746.1 - 4.5e-05 23.2 5.6 4.5e-05 23.2 5.6 4.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP42746.1 - 0.0013 19.0 3.3 0.0013 19.0 3.3 4.6 2 2 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EDP42746.1 - 0.0019 18.2 2.0 0.0019 18.2 2.0 3.8 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDP42746.1 - 0.012 15.4 2.2 0.012 15.4 2.2 5.2 3 2 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP42746.1 - 0.054 13.7 0.6 0.054 13.7 0.6 4.5 4 1 0 4 4 4 0 zinc finger of C3HC4-type, RING 3HCDH_N PF02737.18 EDP42747.1 - 1.2e-54 184.9 1.7 2e-54 184.2 1.7 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EDP42747.1 - 9.1e-31 106.3 0.0 2.1e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EDP42747.1 - 0.0021 17.7 0.9 0.0049 16.5 0.9 1.6 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 EDP42747.1 - 0.024 14.8 4.9 0.62 10.2 3.6 2.4 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EDP42747.1 - 0.026 14.8 4.3 0.13 12.5 4.3 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 EDP42747.1 - 0.069 12.5 0.1 0.084 12.2 0.1 1.2 1 0 0 1 1 1 0 ThiF family Ribosomal_L11 PF00298.19 EDP42747.1 - 0.14 12.7 2.0 0.2 12.2 0.5 2.1 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain Phenol_Hydrox PF02332.18 EDP42747.1 - 0.19 11.3 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase F420_oxidored PF03807.17 EDP42747.1 - 2.2 8.9 5.3 54 4.5 5.3 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Glycos_transf_2 PF00535.26 EDP42748.1 - 7.8e-34 116.9 0.0 9.8e-34 116.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDP42748.1 - 2e-13 50.8 0.0 3e-13 50.2 0.0 1.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EDP42748.1 - 8.3e-05 22.2 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDP42748.1 - 0.00057 19.4 0.0 0.0013 18.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EDP42748.1 - 0.014 15.9 0.0 0.038 14.5 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_7N PF13733.6 EDP42748.1 - 0.052 13.2 0.1 0.086 12.5 0.1 1.3 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 WD40 PF00400.32 EDP42749.1 - 8.1e-27 92.9 7.2 1.7e-08 35.0 0.2 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Sof1 PF04158.14 EDP42749.1 - 1.3e-25 89.4 8.9 2.5e-25 88.6 8.9 1.4 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EDP42749.1 - 4e-09 36.7 0.1 0.13 12.5 0.0 4.5 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDP42749.1 - 0.0012 18.8 0.0 0.0027 17.6 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A NT-C2 PF10358.9 EDP42750.1 - 2.4e-09 37.0 0.0 1.9e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins Pribosyltran_N PF13793.6 EDP42751.1 - 7.1e-43 145.3 0.3 4.5e-42 142.7 0.0 2.2 2 1 1 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EDP42751.1 - 4e-38 131.3 1.2 3.2e-33 115.3 0.5 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EDP42751.1 - 1e-14 54.3 0.2 3e-14 52.8 0.2 1.8 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDP42751.1 - 0.0099 15.3 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase LSM PF01423.22 EDP42752.1 - 8.5e-18 63.8 0.6 1.1e-17 63.5 0.6 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDP42752.1 - 0.054 13.6 0.1 0.066 13.4 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain BPL_C PF02237.17 EDP42752.1 - 0.076 12.9 0.5 0.15 11.9 0.5 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Hfq PF17209.3 EDP42752.1 - 0.16 11.7 0.1 0.23 11.1 0.1 1.2 1 0 0 1 1 1 0 Hfq protein XPG_I PF00867.18 EDP42753.1 - 1.3e-24 86.4 0.0 2.1e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EDP42753.1 - 3.9e-05 23.3 0.0 6.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 EDP42753.1 - 0.0071 16.9 0.0 0.014 16.0 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold TFIIIC_sub6 PF10419.9 EDP42754.1 - 2.3e-11 43.4 0.0 3.2e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain UDPG_MGDP_dh_N PF03721.14 EDP42755.1 - 6e-57 192.2 0.0 9.4e-57 191.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 EDP42755.1 - 4e-35 120.4 0.0 8.9e-35 119.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 EDP42755.1 - 3.6e-31 107.2 0.0 6.5e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sacchrp_dh_NADP PF03435.18 EDP42755.1 - 0.0055 17.0 0.6 0.057 13.7 0.0 2.5 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EDP42755.1 - 0.052 13.7 0.0 0.27 11.4 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Abhydrolase_6 PF12697.7 EDP42756.1 - 0.042 14.4 1.4 0.068 13.8 0.2 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase family Ribosomal_L1 PF00687.21 EDP42757.1 - 5.3e-57 192.9 0.1 9.2e-57 192.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF1077 PF06417.12 EDP42758.1 - 2.7e-43 146.7 5.6 3.5e-43 146.4 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Pyr_redox_2 PF07992.14 EDP42759.1 - 8.1e-23 81.1 0.0 1.3e-20 73.8 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP42759.1 - 6.3e-14 52.3 0.0 1.2e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDP42759.1 - 0.015 14.4 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDP42759.1 - 0.15 12.0 0.1 17 5.4 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding Ribosomal_S24e PF01282.19 EDP42760.1 - 7.7e-33 112.3 0.0 1.2e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e LSM PF01423.22 EDP42761.1 - 2.4e-14 52.7 0.0 2.7e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.21 EDP42762.1 - 6.5e-19 67.9 0.0 9.3e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDP42762.1 - 0.023 15.0 0.0 0.31 11.4 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein L5 Clathrin PF00637.20 EDP42763.1 - 4.8e-16 58.9 0.2 1.2e-15 57.7 0.2 1.7 1 0 0 1 1 1 1 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 EDP42763.1 - 0.034 14.2 0.5 0.12 12.4 0.5 1.9 1 0 0 1 1 1 0 Zinc-finger RAB3GAP2_N PF14655.6 EDP42763.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1180 PF06679.12 EDP42763.1 - 0.37 11.2 1.3 0.78 10.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) zf-RING_UBOX PF13445.6 EDP42763.1 - 0.38 10.8 6.6 0.1 12.6 1.2 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 EDP42763.1 - 0.52 10.7 7.1 0.64 10.4 2.0 3.1 3 0 0 3 3 3 0 Ring finger domain zf-RING_5 PF14634.6 EDP42763.1 - 1.6 8.8 7.3 0.15 12.1 1.6 2.2 2 0 0 2 2 2 0 zinc-RING finger domain GRIM-19 PF06212.12 EDP42764.1 - 6.8e-17 61.7 0.0 7.4e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein Nop14 PF04147.12 EDP42765.1 - 1.2e-264 880.7 19.8 1.5e-264 880.4 19.8 1.0 1 0 0 1 1 1 1 Nop14-like family Cullin_binding PF03556.15 EDP42766.1 - 0.004 17.6 0.1 0.0049 17.3 0.1 1.3 1 0 0 1 1 1 1 Cullin binding C2-set_2 PF08205.12 EDP42766.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain LSM PF01423.22 EDP42767.1 - 4.9e-17 61.4 0.2 3.8e-09 36.1 0.0 2.0 2 0 0 2 2 2 2 LSM domain SM-ATX PF14438.6 EDP42767.1 - 0.014 15.5 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF2167 PF09935.9 EDP42767.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) MFS_2 PF13347.6 EDP42768.1 - 3.7e-15 55.4 4.0 5.7e-15 54.8 4.0 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 EDP42768.1 - 0.00085 18.3 0.0 0.0015 17.5 0.0 1.5 1 1 0 1 1 1 1 MFS_1 like family PUCC PF03209.15 EDP42768.1 - 0.0018 17.3 5.5 0.0043 16.1 4.6 1.9 1 1 1 2 2 2 1 PUCC protein DUF4112 PF13430.6 EDP42768.1 - 0.16 12.2 0.6 1 9.6 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) DUF2644 PF10841.8 EDP42768.1 - 0.17 12.1 0.6 0.93 9.8 0.6 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) 14-3-3 PF00244.20 EDP42769.1 - 2.2e-107 357.6 4.4 2.5e-107 357.4 4.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Adaptin_N PF01602.20 EDP42770.1 - 1.5e-92 310.8 5.7 2e-92 310.5 5.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EDP42770.1 - 0.0089 16.4 1.8 0.12 12.8 0.1 2.7 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EDP42770.1 - 0.019 15.2 0.5 1.6 9.2 0.1 3.5 3 0 0 3 3 3 0 HEAT repeat DUF3106 PF11304.8 EDP42770.1 - 0.1 13.1 0.4 0.22 12.0 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) RRN3 PF05327.11 EDP42771.1 - 4.4e-106 355.7 7.8 4.9e-106 355.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 EDP42771.1 - 2.9 7.7 10.1 17 5.2 7.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Ras PF00071.22 EDP42772.1 - 8.5e-50 168.5 0.0 1e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP42772.1 - 5.6e-30 104.0 0.0 8.8e-30 103.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP42772.1 - 6.4e-10 38.8 0.0 8.8e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDP42772.1 - 0.0002 20.8 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDP42772.1 - 0.00077 19.5 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EDP42772.1 - 0.0035 16.5 1.0 1.5 7.9 0.1 2.7 2 1 0 3 3 3 2 G-protein alpha subunit RNA_helicase PF00910.22 EDP42772.1 - 0.018 15.4 0.1 0.19 12.2 0.1 2.2 1 1 0 1 1 1 0 RNA helicase Pox_A32 PF04665.12 EDP42772.1 - 0.018 14.5 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 EDP42772.1 - 0.027 14.0 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF5118 PF17162.4 EDP42772.1 - 0.036 13.9 0.1 0.07 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) RsgA_GTPase PF03193.16 EDP42772.1 - 0.047 13.6 0.1 6 6.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EDP42772.1 - 0.051 13.3 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDP42772.1 - 0.062 13.7 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EDP42772.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE STAS PF01740.21 EDP42772.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 1 1 0 1 1 1 0 STAS domain AAA_33 PF13671.6 EDP42772.1 - 0.13 12.4 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EDP42772.1 - 0.17 11.2 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Septin RPA43_OB PF17875.1 EDP42773.1 - 7.2e-21 75.1 0.1 7.2e-21 75.1 0.1 4.9 2 2 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EDP42773.1 - 9e-08 32.4 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 LAP1C PF05609.12 EDP42773.1 - 5.7 5.9 25.2 7.5 5.5 25.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Thioredoxin PF00085.20 EDP42774.1 - 2.8e-15 56.2 0.0 4e-15 55.7 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDP42774.1 - 5.5e-05 23.4 0.0 7e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EDP42774.1 - 0.00016 21.8 0.0 0.00025 21.2 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EDP42774.1 - 0.0051 17.3 0.1 0.038 14.5 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EDP42774.1 - 0.011 15.7 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 EDP42774.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Redoxin Thioredoxin_9 PF14595.6 EDP42774.1 - 0.044 13.5 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 EDP42774.1 - 0.059 13.8 0.0 0.32 11.5 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) RasGAP PF00616.19 EDP42775.1 - 0.00015 21.6 0.0 0.00051 19.8 0.0 1.7 1 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Methyltransf_16 PF10294.9 EDP42776.1 - 3.9e-14 52.8 0.0 4.9e-11 42.7 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 EDP42776.1 - 0.0046 16.5 0.0 0.0095 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EDP42776.1 - 0.13 12.9 0.1 0.39 11.5 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42776.1 - 0.19 11.5 0.0 0.37 10.6 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain MT-A70 PF05063.14 EDP42777.1 - 1.8e-54 184.3 0.0 3.3e-54 183.4 0.0 1.4 1 1 0 1 1 1 1 MT-A70 Cadherin_C_2 PF16492.5 EDP42778.1 - 0.018 15.8 0.2 1.2 9.9 0.0 2.8 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal WD40 PF00400.32 EDP42779.1 - 3.1e-26 91.1 28.4 2.6e-05 24.9 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EDP42779.1 - 6.1e-13 48.4 2.1 2.1e-12 46.7 2.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDP42779.1 - 1.4e-07 31.2 0.6 3.2e-07 30.0 0.6 1.6 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.6 EDP42779.1 - 1.3e-06 28.4 0.0 0.012 15.6 0.0 3.3 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EDP42779.1 - 0.00017 21.8 0.1 2.5 8.5 0.0 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain ecTbetaR2 PF08917.10 EDP42779.1 - 0.38 10.7 0.1 0.38 10.7 0.1 2.5 3 1 0 3 3 3 0 Transforming growth factor beta receptor 2 ectodomain Pal1 PF08316.11 EDP42780.1 - 1.3e-13 51.9 3.5 6.5e-13 49.6 3.0 2.3 1 1 1 2 2 2 1 Pal1 cell morphology protein SCP2 PF02036.17 EDP42781.1 - 6.2e-24 84.4 1.9 7.4e-24 84.2 1.9 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EDP42781.1 - 0.0036 17.6 0.6 0.0042 17.4 0.6 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Bot1p PF12298.8 EDP42783.1 - 8.9e-23 81.3 0.0 1.4e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein MRP-L20 PF12824.7 EDP42783.1 - 0.0082 16.3 0.1 0.0082 16.3 0.1 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 His_Phos_2 PF00328.22 EDP42785.1 - 9.5e-70 235.9 0.1 1.3e-69 235.4 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EDP42785.1 - 6e-35 119.3 0.1 1.9e-34 117.7 0.1 1.9 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EDP42785.1 - 8.5e-08 32.0 0.0 1.8e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain LETM1 PF07766.13 EDP42786.1 - 1e-11 44.7 1.1 1.3e-11 44.3 1.1 1.1 1 0 0 1 1 1 1 LETM1-like protein LSM PF01423.22 EDP42787.1 - 5.7e-17 61.2 0.2 8.2e-17 60.7 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDP42787.1 - 0.021 14.5 0.1 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 Hfq protein WD40 PF00400.32 EDP42789.1 - 1.7e-07 31.8 6.0 0.66 10.9 0.1 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat Lyase_8_C PF02884.17 EDP42789.1 - 0.065 13.7 0.0 21 5.7 0.0 2.4 2 0 0 2 2 2 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain TRAPPC-Trs85 PF12739.7 EDP42790.1 - 3.2e-72 243.7 12.8 5.2e-72 243.1 12.8 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Alpha_adaptinC2 PF02883.20 EDP42790.1 - 0.19 12.0 0.0 7.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Adaptin C-terminal domain SNAP PF14938.6 EDP42790.1 - 0.46 9.9 7.5 0.27 10.6 1.1 2.4 1 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP Pex24p PF06398.11 EDP42791.1 - 1e-28 100.4 0.1 1.6e-28 99.8 0.1 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin NAD_binding_1 PF00175.21 EDP42792.1 - 5.5e-10 39.9 0.0 1e-09 39.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 EDP42792.1 - 6.7e-10 39.5 0.1 1.2e-08 35.5 0.1 2.3 2 0 0 2 2 2 1 Globin Protoglobin PF11563.8 EDP42792.1 - 7.1e-05 22.8 0.1 0.00012 22.0 0.1 1.4 1 0 0 1 1 1 1 Protoglobin NAD_binding_6 PF08030.12 EDP42792.1 - 0.003 17.7 0.6 0.0086 16.2 0.1 1.9 2 1 1 3 3 3 1 Ferric reductase NAD binding domain RRM_1 PF00076.22 EDP42793.1 - 3.2e-39 132.6 0.0 2.4e-20 72.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP42793.1 - 1.9e-06 27.9 0.0 0.00097 19.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EDP42793.1 - 0.014 15.4 0.0 0.54 10.3 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RNA_pol_Rpb1_1 PF04997.12 EDP42794.1 - 6.4e-84 281.9 0.0 9e-84 281.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EDP42794.1 - 2.1e-83 279.9 0.3 3.3e-83 279.2 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EDP42794.1 - 3.2e-71 238.9 0.0 6.3e-71 237.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EDP42794.1 - 1.5e-38 132.2 0.0 4.3e-38 130.7 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EDP42794.1 - 9.4e-31 106.0 0.0 2.2e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 zf-RING_7 PF02591.15 EDP42794.1 - 0.0029 17.8 0.2 0.75 10.0 0.0 3.0 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf-ISL3 PF14690.6 EDP42794.1 - 0.02 15.5 3.2 0.17 12.6 0.3 2.9 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_10 PF10058.9 EDP42794.1 - 0.079 12.7 0.9 1.9 8.3 0.1 2.6 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf_CopZ PF18423.1 EDP42794.1 - 0.38 10.8 1.6 0.7 9.9 0.1 2.2 2 0 0 2 2 2 0 Zinc binding domain zf-ribbon_3 PF13248.6 EDP42794.1 - 2.3 7.7 4.7 5 6.7 0.3 3.1 3 0 0 3 3 3 0 zinc-ribbon domain ThiF PF00899.21 EDP42796.1 - 1.9e-102 341.8 0.0 1.6e-68 230.7 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EDP42796.1 - 1.4e-88 297.1 0.1 2.1e-88 296.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EDP42796.1 - 2e-33 114.4 0.6 4.4e-33 113.3 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EDP42796.1 - 1.2e-27 96.5 0.0 2.2e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EDP42796.1 - 3.9e-24 84.6 0.1 1.5e-23 82.8 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle End_beta_barrel PF12195.8 EDP42796.1 - 0.08 12.9 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Beta barrel domain of bacteriophage endosialidase ANTAR PF03861.14 EDP42796.1 - 0.14 12.1 0.2 0.3 11.0 0.2 1.5 1 0 0 1 1 1 0 ANTAR domain Pyr_redox PF00070.27 EDP42796.1 - 0.15 12.7 0.5 25 5.5 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SnoaL_2 PF12680.7 EDP42797.1 - 0.14 12.8 0.0 0.48 11.1 0.0 1.9 2 0 0 2 2 2 0 SnoaL-like domain NAD_binding_2 PF03446.15 EDP42798.1 - 0.54 10.4 3.4 0.18 11.9 0.3 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Med13_C PF06333.12 EDP42799.1 - 2e-12 47.0 1.2 2e-12 47.0 1.2 3.5 3 2 1 4 4 4 2 Mediator complex subunit 13 C-terminal domain Halogen_Hydrol PF10112.9 EDP42800.1 - 0.16 12.0 0.1 0.16 12.0 0.1 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein CDT1_C PF16679.5 EDP42802.1 - 2.1e-15 56.9 0.3 5.5e-15 55.6 0.3 1.8 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain CDT1 PF08839.11 EDP42802.1 - 5.3e-08 33.4 0.0 0.0079 16.5 0.0 3.3 2 1 0 2 2 2 2 DNA replication factor CDT1 like Iso_dh PF00180.20 EDP42803.1 - 2.8e-88 296.4 0.0 3.3e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GTP_EFTU PF00009.27 EDP42804.1 - 8.9e-44 149.4 0.0 1.3e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDP42804.1 - 3.9e-09 36.6 0.0 4.6e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 EDP42804.1 - 2.4e-06 27.8 0.0 5.7e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Arf PF00025.21 EDP42804.1 - 0.0033 16.9 0.0 1.1 8.7 0.0 2.2 1 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EDP42804.1 - 0.0098 16.1 0.0 1.7 8.9 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D2 PF03144.25 EDP42804.1 - 0.087 13.2 0.2 1.8 9.0 0.0 2.6 3 0 0 3 3 3 0 Elongation factor Tu domain 2 FeoB_N PF02421.18 EDP42804.1 - 0.14 11.6 0.0 7.9 6.0 0.0 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B SRPRB PF09439.10 EDP42804.1 - 0.21 11.0 0.0 3.8 6.9 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Myb_DNA-binding PF00249.31 EDP42805.1 - 1.3e-29 102.1 5.8 2.1e-11 43.8 0.4 4.3 4 0 0 4 4 4 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP42805.1 - 1.2e-23 83.1 0.4 3e-08 33.8 0.0 4.6 3 1 1 4 4 4 4 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EDP42805.1 - 0.0053 17.1 0.5 1.8 9.0 0.0 3.5 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 EDP42805.1 - 0.22 11.6 0.7 3.3 7.9 0.3 2.8 2 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Sedlin_N PF04628.13 EDP42806.1 - 6.7e-20 71.5 0.5 2.2e-15 56.9 0.4 3.1 2 1 0 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.12 EDP42806.1 - 7.2e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 1 0 1 1 1 1 Sybindin-like family Methyltransf_30 PF05430.11 EDP42807.1 - 0.1 12.5 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase PRKCSH_1 PF13015.6 EDP42808.1 - 1.4e-28 99.5 0.3 2.1e-28 99.0 0.3 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EDP42808.1 - 3.1e-11 44.1 1.6 5.7e-11 43.3 0.6 1.9 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EDP42808.1 - 0.02 14.8 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Lebercilin PF15619.6 EDP42808.1 - 0.067 12.9 1.5 0.091 12.4 0.3 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TRAF_BIRC3_bd PF16673.5 EDP42808.1 - 0.09 12.6 0.4 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain HR1 PF02185.16 EDP42808.1 - 0.22 11.7 1.7 19 5.5 0.3 2.3 2 0 0 2 2 2 0 Hr1 repeat HalX PF08663.10 EDP42808.1 - 1.6 9.1 6.3 0.91 9.9 3.0 2.1 2 0 0 2 2 2 0 HalX domain Pox_A_type_inc PF04508.12 EDP42808.1 - 6.7 6.8 8.7 0.65 9.9 4.1 1.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Acyltransferase PF01553.21 EDP42809.1 - 4.1e-33 113.9 0.0 5.9e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase BTB PF00651.31 EDP42810.1 - 0.00022 21.4 0.0 0.00057 20.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain RabGAP-TBC PF00566.18 EDP42811.1 - 2.6e-19 69.7 5.1 9.5e-16 58.1 0.7 3.0 3 0 0 3 3 3 3 Rab-GTPase-TBC domain Rab5ip PF07019.12 EDP42812.1 - 5.6e-14 52.5 5.2 1e-13 51.7 5.2 1.4 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) WD40 PF00400.32 EDP42813.1 - 7.9e-12 45.5 10.3 2.9e-06 27.9 1.6 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42813.1 - 9e-10 38.7 0.0 0.045 14.1 0.0 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EDP42813.1 - 0.0017 17.5 0.0 0.0035 16.4 0.0 1.5 2 0 0 2 2 2 1 Coatomer WD associated region AAA_2 PF07724.14 EDP42814.1 - 1.6e-51 174.8 0.0 3e-49 167.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EDP42814.1 - 1.6e-31 108.3 1.3 1.6e-31 108.3 1.3 3.9 3 1 1 4 4 4 1 AAA lid domain AAA PF00004.29 EDP42814.1 - 3.8e-26 92.1 0.0 1.3e-14 54.8 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EDP42814.1 - 2e-21 75.8 0.1 8.7e-21 73.8 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EDP42814.1 - 1.8e-14 53.9 0.0 5.9e-09 36.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 EDP42814.1 - 7.3e-11 42.0 4.8 4.8e-05 23.4 0.2 4.0 3 0 0 3 3 3 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 EDP42814.1 - 1.1e-10 42.2 7.5 5.8e-06 26.8 0.1 5.5 4 2 1 6 6 5 1 AAA ATPase domain AAA_22 PF13401.6 EDP42814.1 - 2.2e-08 34.5 0.4 0.064 13.5 0.0 5.4 4 1 1 5 5 4 2 AAA domain Sigma54_activat PF00158.26 EDP42814.1 - 1.3e-07 31.4 0.0 1.9e-05 24.4 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 EDP42814.1 - 2.2e-06 27.2 0.0 0.0051 16.2 0.0 3.6 3 0 0 3 3 3 1 Bacterial TniB protein AAA_7 PF12775.7 EDP42814.1 - 9.8e-06 25.2 0.0 0.049 13.2 0.0 2.9 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_33 PF13671.6 EDP42814.1 - 1.3e-05 25.3 2.3 0.13 12.4 0.0 4.0 2 1 1 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EDP42814.1 - 2.5e-05 24.1 0.0 0.12 12.1 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EDP42814.1 - 6.7e-05 23.2 0.0 0.34 11.3 0.0 3.2 3 0 0 3 3 3 2 RNA helicase AAA_24 PF13479.6 EDP42814.1 - 0.00017 21.3 0.0 0.34 10.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EDP42814.1 - 0.00021 21.3 0.1 0.89 9.4 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase Mg_chelatase PF01078.21 EDP42814.1 - 0.00057 19.3 0.0 0.38 10.1 0.0 2.7 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDP42814.1 - 0.00068 20.0 0.7 0.15 12.4 0.0 3.9 3 1 0 3 3 3 1 AAA domain AAA_28 PF13521.6 EDP42814.1 - 0.001 19.3 1.0 0.47 10.7 0.0 3.6 3 1 1 4 4 3 1 AAA domain Zeta_toxin PF06414.12 EDP42814.1 - 0.0012 18.2 0.0 0.79 9.0 0.0 3.0 3 0 0 3 3 2 1 Zeta toxin AAA_18 PF13238.6 EDP42814.1 - 0.002 18.7 0.1 3.5 8.2 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EDP42814.1 - 0.0026 17.5 0.2 2 8.1 0.0 3.7 4 0 0 4 4 3 1 AAA domain RuvB_N PF05496.12 EDP42814.1 - 0.0044 16.8 0.1 9.9 5.9 0.0 3.6 4 0 0 4 4 3 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 EDP42814.1 - 0.0048 16.0 0.0 0.02 14.0 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.6 EDP42814.1 - 0.005 16.9 0.0 6.5 6.8 0.0 3.6 3 1 0 3 3 3 0 AAA domain TsaE PF02367.17 EDP42814.1 - 0.0058 16.6 0.0 2.3 8.2 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EDP42814.1 - 0.0072 15.9 3.8 0.069 12.7 0.0 3.4 2 1 0 3 3 3 1 AAA domain DUF815 PF05673.13 EDP42814.1 - 0.031 13.4 0.0 0.63 9.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EDP42814.1 - 0.041 13.8 0.0 0.041 13.8 0.0 4.1 3 2 0 4 4 4 0 ATPase domain predominantly from Archaea Roc PF08477.13 EDP42814.1 - 0.044 14.0 0.0 8.9 6.6 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 EDP42814.1 - 0.055 12.9 0.0 1.7 8.1 0.0 2.9 3 0 0 3 3 3 0 PhoH-like protein SRP54 PF00448.22 EDP42814.1 - 0.074 12.7 0.0 14 5.2 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain EMP24_GP25L PF01105.24 EDP42814.1 - 0.097 12.6 0.7 0.23 11.4 0.7 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD AAA_3 PF07726.11 EDP42814.1 - 0.11 12.3 0.0 19 5.1 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EDP42814.1 - 0.12 12.2 0.0 22 4.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain FTA4 PF13093.6 EDP42814.1 - 0.22 11.4 4.1 0.47 10.3 4.1 1.5 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Spc7 PF08317.11 EDP42814.1 - 0.24 10.2 12.1 0.4 9.5 10.9 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Tup_N PF08581.10 EDP42814.1 - 0.3 11.4 4.2 2.7 8.4 2.2 2.9 2 0 0 2 2 2 0 Tup N-terminal Laminin_II PF06009.12 EDP42814.1 - 0.36 10.9 7.9 0.098 12.7 3.6 2.3 2 0 0 2 2 2 0 Laminin Domain II LUC7 PF03194.15 EDP42814.1 - 0.73 9.5 7.4 2.3 7.8 7.4 1.8 1 0 0 1 1 1 0 LUC7 N_terminus Fzo_mitofusin PF04799.13 EDP42814.1 - 2.4 7.7 3.9 2.5 7.6 1.4 2.2 2 0 0 2 2 2 0 fzo-like conserved region HIP1_clath_bdg PF16515.5 EDP42814.1 - 2.9 8.6 10.3 0.4 11.3 4.9 2.3 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exonuc_VII_L PF02601.15 EDP42814.1 - 3.6 7.1 10.0 0.79 9.2 4.4 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Atg14 PF10186.9 EDP42814.1 - 4.7 6.2 6.6 8.8 5.3 6.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 EDP42814.1 - 5.6 7.4 11.6 38 4.7 0.0 3.6 3 1 0 3 3 3 0 AAA domain bZIP_1 PF00170.21 EDP42815.1 - 7.9e-13 48.3 4.3 1.2e-12 47.7 4.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDP42815.1 - 3.5e-09 36.6 3.9 5.6e-09 36.0 3.9 1.3 1 0 0 1 1 1 1 Basic region leucine zipper HAP1_N PF04849.13 EDP42815.1 - 0.025 13.8 1.3 0.037 13.2 1.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Nnf1 PF03980.14 EDP42815.1 - 0.031 14.6 0.4 0.058 13.8 0.4 1.4 1 0 0 1 1 1 0 Nnf1 HALZ PF02183.18 EDP42815.1 - 0.032 14.4 0.1 0.058 13.6 0.1 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_Maf PF03131.17 EDP42815.1 - 0.043 14.3 1.6 0.095 13.2 1.6 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Yuri_gagarin PF15934.5 EDP42815.1 - 0.043 13.6 0.2 0.065 13.1 0.2 1.2 1 0 0 1 1 1 0 Yuri gagarin CCDC106 PF15794.5 EDP42815.1 - 6.3 6.5 13.3 0.16 11.6 1.3 2.9 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 106 RRM_1 PF00076.22 EDP42816.1 - 8.6e-21 73.5 0.1 3.5e-16 58.8 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP42816.1 - 8.6e-05 22.1 0.0 0.00024 20.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP42816.1 - 0.003 17.4 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_8 PF11835.8 EDP42816.1 - 0.0032 17.6 0.0 0.0056 16.9 0.0 1.4 1 0 0 1 1 1 1 RRM-like domain Aldedh PF00171.22 EDP42817.1 - 4.8e-78 262.7 0.0 5.6e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fic PF02661.18 EDP42817.1 - 0.12 13.3 0.0 0.26 12.2 0.0 1.6 1 0 0 1 1 1 0 Fic/DOC family Pkinase PF00069.25 EDP42818.1 - 1.4e-70 237.7 0.0 1.7e-70 237.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42818.1 - 5.9e-41 140.5 0.0 7.9e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP42818.1 - 5.1e-10 39.1 0.0 7.2e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDP42818.1 - 0.0011 18.4 0.1 0.0069 15.8 0.0 2.1 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDP42818.1 - 0.0032 16.5 0.0 0.0075 15.3 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP42818.1 - 0.026 14.4 0.5 0.18 11.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family HAD PF12710.7 EDP42819.1 - 1.3e-12 48.5 0.0 1.8e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EDP42819.1 - 1.2e-05 25.0 0.1 0.0002 21.0 0.0 2.2 1 1 1 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 EDP42819.1 - 0.018 15.3 0.1 0.51 10.6 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Proteasome PF00227.26 EDP42820.1 - 1.7e-58 197.3 0.0 2.8e-58 196.6 0.0 1.3 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EDP42820.1 - 2e-09 36.9 0.0 7.4e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature NUC153 PF08159.12 EDP42821.1 - 6.8e-13 48.2 0.4 1.4e-12 47.2 0.4 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EDP42821.1 - 0.027 15.3 0.8 32 5.6 0.0 4.2 4 0 0 4 4 4 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42821.1 - 0.085 13.2 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Trypan_PARP PF05887.11 EDP42821.1 - 3.9 7.5 16.4 4.9 7.1 12.4 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ribosomal_L11 PF00298.19 EDP42822.1 - 3.7e-24 85.0 1.5 5.9e-24 84.4 1.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EDP42822.1 - 7.3e-22 77.0 2.2 9.2e-22 76.7 0.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain adh_short_C2 PF13561.6 EDP42823.1 - 5.2e-57 193.1 0.1 6.5e-57 192.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDP42823.1 - 2.8e-46 157.5 2.9 3.6e-46 157.1 2.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDP42823.1 - 9.1e-17 61.5 0.1 1.2e-16 61.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDP42823.1 - 2.4e-06 27.2 0.2 3.1e-06 26.8 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDP42823.1 - 0.00035 20.1 0.1 0.00045 19.7 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 EDP42823.1 - 0.0011 18.9 0.3 0.076 12.9 0.3 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EDP42823.1 - 0.0013 19.2 0.4 0.46 11.1 0.2 2.6 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Peripla_BP_4 PF13407.6 EDP42823.1 - 0.02 14.5 0.1 0.028 14.0 0.1 1.3 1 1 0 1 1 1 0 Periplasmic binding protein domain PALP PF00291.25 EDP42823.1 - 0.031 13.7 1.6 0.1 12.0 1.6 1.9 1 1 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme NifU_N PF01592.16 EDP42824.1 - 1.5e-54 183.5 0.1 2e-54 183.1 0.1 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Snf7 PF03357.21 EDP42825.1 - 1.8e-29 102.5 7.6 2.1e-29 102.3 7.6 1.0 1 0 0 1 1 1 1 Snf7 RRP36 PF06102.12 EDP42826.1 - 1.5e-42 145.4 20.4 1.5e-42 145.4 20.4 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Utp14 PF04615.13 EDP42827.1 - 3.6e-128 429.3 53.1 5.6e-126 422.0 53.1 2.0 1 1 0 1 1 1 1 Utp14 protein Utp14 PF04615.13 EDP42828.1 - 2.3e-21 76.1 13.1 2.3e-21 76.1 13.1 2.1 1 1 1 2 2 2 1 Utp14 protein TFIIF_alpha PF05793.12 EDP42828.1 - 1.7 7.1 27.5 2 6.9 27.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EDP42828.1 - 9.9 4.2 26.9 13 3.9 26.9 1.1 1 0 0 1 1 1 0 Nop14-like family UPF0113_N PF17833.1 EDP42829.1 - 2.6e-30 104.8 0.0 4.1e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EDP42829.1 - 1.8e-24 85.8 0.0 2.9e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PP1 PF07430.11 EDP42829.1 - 0.041 13.9 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain Methyltransf_8 PF05148.15 EDP42831.1 - 2.1e-48 165.1 0.0 1.3e-22 80.8 0.0 3.0 3 0 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EDP42831.1 - 2.5e-05 24.9 0.1 0.00015 22.3 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP42831.1 - 0.0005 20.7 0.1 0.0042 17.7 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP42831.1 - 0.00088 19.1 0.0 0.0052 16.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP42831.1 - 0.031 14.1 0.1 7.1 6.4 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EDP42831.1 - 0.078 12.5 0.0 9.4 5.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EDP42831.1 - 0.16 11.3 0.0 0.45 9.8 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family TPX2_importin PF12214.8 EDP42831.1 - 0.34 11.1 6.8 0.93 9.7 3.1 2.5 1 1 1 2 2 2 0 Cell cycle regulated microtubule associated protein Sec7 PF01369.20 EDP42832.1 - 6.1e-70 234.6 0.1 1.8e-69 233.1 0.1 1.9 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDP42832.1 - 4.1e-42 143.8 3.7 4.1e-42 143.8 3.7 3.8 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EDP42832.1 - 2.3e-29 101.1 4.8 3e-28 97.5 0.1 4.3 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) DCB PF16213.5 EDP42832.1 - 1.4e-22 80.2 2.4 2.8e-21 76.0 0.2 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 eIF-6 PF01912.18 EDP42833.1 - 2.1e-80 268.8 0.3 2.9e-80 268.3 0.1 1.3 2 0 0 2 2 2 1 eIF-6 family zf-Tim10_DDP PF02953.15 EDP42834.1 - 3.6e-19 68.2 1.1 4.2e-19 68.0 1.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger THOC2_N PF16134.5 EDP42835.1 - 4.9e-92 309.6 5.9 5e-92 309.6 0.0 2.4 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EDP42835.1 - 4.3e-82 275.7 2.0 4.6e-82 275.6 0.0 1.9 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EDP42835.1 - 2e-31 107.9 0.0 4.3e-31 106.8 0.0 1.6 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Plasmodium_HRP PF05403.11 EDP42835.1 - 0.063 13.1 16.8 0.24 11.2 16.8 2.0 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) Asp-B-Hydro_N PF05279.11 EDP42835.1 - 5.2 7.1 18.2 16 5.4 18.2 1.8 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Adap_comp_sub PF00928.21 EDP42836.1 - 1.2e-38 133.0 0.0 1.7e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Tom22 PF04281.13 EDP42836.1 - 0.15 11.8 1.8 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 WLM PF08325.10 EDP42837.1 - 5.8e-24 85.2 0.2 1e-23 84.4 0.2 1.3 1 0 0 1 1 1 1 WLM domain TBK1_ULD PF18396.1 EDP42837.1 - 0.00016 21.6 0.2 0.00028 20.7 0.2 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 EDP42837.1 - 0.00093 19.6 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EDP42837.1 - 0.0022 17.7 0.1 0.0048 16.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Glyco_hydro_cc PF11790.8 EDP42838.1 - 3.5e-56 190.4 9.8 4.7e-56 190.0 9.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core SH3_1 PF00018.28 EDP42839.1 - 5e-21 74.1 0.0 4.6e-09 35.8 0.0 2.9 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EDP42839.1 - 7.2e-13 48.2 0.0 4.3e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EDP42839.1 - 1.2e-12 47.3 0.0 1.4e-08 34.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EDP42839.1 - 0.0026 17.6 0.0 0.0096 15.8 0.0 2.0 1 0 0 1 1 1 1 PB1 domain PX PF00787.24 EDP42839.1 - 0.0048 16.9 0.1 0.0096 15.9 0.1 1.5 1 0 0 1 1 1 1 PX domain ELYS-bb PF16687.5 EDP42839.1 - 0.043 12.4 0.1 0.063 11.9 0.1 1.1 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin Phage_term_smal PF05944.12 EDP42840.1 - 0.0045 17.0 0.1 8.6 6.3 0.0 3.3 1 1 3 4 4 4 2 Phage small terminase subunit DUF2997 PF11211.8 EDP42840.1 - 0.014 15.1 0.5 37 4.2 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2997) MOZART1 PF12554.8 EDP42840.1 - 0.026 14.3 0.0 43 4.0 0.0 3.3 3 0 0 3 3 3 0 Mitotic-spindle organizing gamma-tubulin ring associated DUF5628 PF18621.1 EDP42840.1 - 0.034 14.6 0.1 11 6.5 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5628) IBN_N PF03810.19 EDP42840.1 - 0.075 13.0 0.2 25 4.9 0.0 3.2 1 1 3 4 4 4 0 Importin-beta N-terminal domain Babuvirus_MP PF07234.11 EDP42840.1 - 0.28 11.4 0.7 2.7 8.2 0.1 2.3 1 1 0 2 2 2 0 Movement and RNA silencing protein GRIP PF01465.20 EDP42840.1 - 2 8.4 8.1 51 3.9 0.0 4.4 5 0 0 5 5 5 0 GRIP domain PTR2 PF00854.21 EDP42842.1 - 1.7e-69 234.6 6.7 2.1e-69 234.3 6.7 1.1 1 0 0 1 1 1 1 POT family MTP18 PF10558.9 EDP42842.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) S4 PF01479.25 EDP42844.1 - 5.3e-09 35.7 0.0 1e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 S4 domain S-AdoMet_synt_C PF02773.16 EDP42845.1 - 3e-68 228.1 0.5 3e-67 224.8 0.0 2.2 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 EDP42845.1 - 7.1e-46 154.9 0.2 1.6e-45 153.8 0.2 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EDP42845.1 - 6.4e-45 152.3 0.0 1.3e-44 151.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 EDP42845.1 - 0.0061 15.4 0.1 0.091 11.5 0.0 2.1 2 0 0 2 2 2 1 S-adenosylmethionine synthetase (AdoMet synthetase) DUF3818 PF12825.7 EDP42846.1 - 3.8e-69 233.3 0.0 5.5e-69 232.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EDP42846.1 - 9.7e-05 22.4 0.2 0.00032 20.7 0.0 1.9 2 0 0 2 2 2 1 PX-associated FAD_binding_1 PF00667.20 EDP42847.1 - 8.3e-50 169.4 0.0 1.4e-49 168.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain POR PF01558.18 EDP42847.1 - 3.3e-09 37.1 0.0 1.4e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 Pyruvate ferredoxin/flavodoxin oxidoreductase NAD_binding_1 PF00175.21 EDP42847.1 - 1.6e-07 32.0 0.0 3.7e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR_N PF01855.19 EDP42847.1 - 0.11 12.2 3.4 0.24 11.1 3.4 1.5 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg YjgF_endoribonc PF14588.6 EDP42847.1 - 0.12 12.5 0.3 0.28 11.3 0.0 1.7 2 0 0 2 2 2 0 YjgF/chorismate_mutase-like, putative endoribonuclease Ribosomal_S7e PF01251.18 EDP42848.1 - 3.5e-78 261.6 0.1 4e-78 261.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF1768 PF08719.11 EDP42849.1 - 3.2e-28 99.0 0.0 4.1e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DAD PF02109.16 EDP42850.1 - 2.4e-42 143.6 1.4 2.8e-42 143.5 1.4 1.0 1 0 0 1 1 1 1 DAD family GTP_EFTU PF00009.27 EDP42851.1 - 2e-43 148.2 0.0 6.2e-43 146.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDP42851.1 - 8.2e-32 109.8 0.0 8.2e-32 109.8 0.0 3.1 5 0 0 5 5 5 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDP42851.1 - 1.4e-08 35.0 0.8 3.9e-08 33.6 0.8 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP42851.1 - 0.0015 18.6 0.0 0.0079 16.3 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase SWI-SNF_Ssr4 PF08549.10 EDP42851.1 - 0.18 10.4 12.8 0.26 9.9 12.8 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DNA_pol3_beta_2 PF02767.16 EDP42851.1 - 0.33 11.2 1.6 0.68 10.2 0.1 2.0 2 0 0 2 2 2 0 DNA polymerase III beta subunit, central domain Hamartin PF04388.12 EDP42851.1 - 0.82 8.3 4.0 1.1 7.8 4.0 1.1 1 0 0 1 1 1 0 Hamartin protein PAM2 PF07145.15 EDP42851.1 - 6.4 6.7 8.3 11 6.0 1.9 3.1 2 1 1 3 3 3 0 Ataxin-2 C-terminal region DUF1640 PF07798.11 EDP42852.1 - 4.7e-59 199.4 1.4 7.9e-59 198.6 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Phage_Mu_Gam PF07352.12 EDP42852.1 - 0.018 14.9 1.0 0.039 13.9 1.0 1.5 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Prominin PF05478.11 EDP42852.1 - 0.11 10.4 2.2 0.15 10.0 2.2 1.1 1 0 0 1 1 1 0 Prominin zf-ZPR1 PF03367.13 EDP42852.1 - 0.17 11.7 2.5 0.3 10.9 2.5 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain OmpH PF03938.14 EDP42852.1 - 5.6 7.3 10.0 0.11 12.8 3.2 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Rho_GDI PF02115.17 EDP42853.1 - 2.4e-54 184.0 0.0 3.2e-54 183.6 0.0 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Complex1_LYR PF05347.15 EDP42854.1 - 1.2e-08 34.8 4.7 2.1e-08 34.1 4.7 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDP42854.1 - 0.13 13.0 1.4 0.24 12.2 1.3 1.6 1 1 0 1 1 1 0 Complex1_LYR-like LEF-4 PF05098.12 EDP42854.1 - 0.18 10.6 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Late expression factor 4 (LEF-4) VWA_2 PF13519.6 EDP42855.1 - 0.0035 18.0 0.0 0.0089 16.7 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain Flavin_Reduct PF01613.18 EDP42856.1 - 2.3e-26 92.7 0.4 3e-26 92.3 0.4 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Sedlin_N PF04628.13 EDP42857.1 - 2.5e-22 79.4 0.1 3.8e-22 78.8 0.1 1.4 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region COA2 PF17051.5 EDP42858.1 - 0.0011 19.0 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Pkinase PF00069.25 EDP42859.1 - 2.2e-58 197.7 0.0 1.4e-57 195.1 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42859.1 - 1.2e-41 142.8 0.0 1.3e-40 139.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 EDP42859.1 - 5e-34 117.8 0.1 1.4e-33 116.4 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_fungal PF17667.1 EDP42859.1 - 0.0039 16.0 0.0 0.0062 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP42859.1 - 0.016 14.5 0.2 0.28 10.4 0.1 3.0 4 1 0 4 4 4 0 Kinase-like APH PF01636.23 EDP42859.1 - 0.016 15.1 2.5 0.098 12.6 0.0 2.9 2 2 0 2 2 2 0 Phosphotransferase enzyme family YihI PF04220.12 EDP42859.1 - 0.14 11.9 0.0 0.68 9.7 0.0 2.1 2 0 0 2 2 2 0 Der GTPase activator (YihI) Pkinase PF00069.25 EDP42860.1 - 3.6e-71 239.6 0.0 4.9e-71 239.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42860.1 - 2.3e-30 105.8 0.0 1.1e-22 80.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDP42860.1 - 4.3e-08 32.8 0.0 0.05 12.9 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EDP42860.1 - 0.00044 19.2 0.3 0.0015 17.4 0.0 1.9 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EDP42860.1 - 0.027 14.4 0.1 0.74 9.7 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDP42860.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDP42860.1 - 0.13 11.9 0.0 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TFIIA PF03153.13 EDP42860.1 - 6.7 6.6 10.0 18 5.2 10.0 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SART-1 PF03343.13 EDP42861.1 - 3e-126 422.5 37.8 3.7e-126 422.2 37.8 1.1 1 0 0 1 1 1 1 SART-1 family RhoGAP PF00620.27 EDP42862.1 - 4e-23 81.9 0.0 8.8e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain AICARFT_IMPCHas PF01808.18 EDP42862.1 - 0.25 10.7 0.0 0.38 10.1 0.0 1.2 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme NOT2_3_5 PF04153.18 EDP42864.1 - 9.7e-45 151.9 10.0 9.7e-45 151.9 10.0 1.8 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Not3 PF04065.15 EDP42864.1 - 2.8e-43 148.0 8.6 4.5e-43 147.3 8.6 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component DUF2373 PF10180.9 EDP42864.1 - 0.0055 16.5 2.8 0.011 15.5 2.8 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) PulA_N1 PF17999.1 EDP42864.1 - 0.054 14.2 0.2 0.11 13.2 0.2 1.5 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Ribosomal_L19 PF01245.20 EDP42865.1 - 3.1e-17 62.5 0.9 7.2e-17 61.3 0.9 1.5 1 1 0 1 1 1 1 Ribosomal protein L19 Aminotran_1_2 PF00155.21 EDP42866.1 - 7.4e-73 245.8 0.0 9e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDP42866.1 - 2.6e-07 29.9 0.0 4.9e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EDP42866.1 - 5.9e-05 21.8 0.0 0.00023 19.9 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EDP42866.1 - 0.0086 15.4 0.2 0.018 14.4 0.2 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EDP42866.1 - 0.011 15.0 0.2 0.032 13.5 0.2 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase FliC_SP PF12613.8 EDP42866.1 - 0.021 15.3 0.7 0.063 13.8 0.7 1.8 1 0 0 1 1 1 0 Flagellin structural protein Ytp1 PF10355.9 EDP42867.1 - 8.1e-106 353.3 3.6 1.2e-105 352.8 3.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EDP42867.1 - 1e-07 31.6 1.2 1e-07 31.6 1.2 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Abhydrolase_3 PF07859.13 EDP42868.1 - 1.5e-21 77.2 0.0 5.4e-21 75.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDP42868.1 - 5.7e-21 74.8 0.0 6.2e-16 58.2 0.0 2.1 2 0 0 2 2 2 2 Steryl acetyl hydrolase C2 PF00168.30 EDP42870.1 - 2.1e-09 37.6 0.0 3e-07 30.7 0.0 2.2 1 1 0 1 1 1 1 C2 domain RasGAP_C PF03836.15 EDP42871.1 - 3e-08 33.9 0.0 4.3e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 RasGAP C-terminus TypeIII_RM_meth PF12564.8 EDP42871.1 - 0.063 13.4 1.4 0.28 11.3 0.3 2.1 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit Drf_FH3 PF06367.16 EDP42872.1 - 2.1e-46 158.0 0.6 2.1e-46 158.0 0.6 2.4 1 1 1 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EDP42872.1 - 6.6e-42 143.2 0.0 1.5e-41 142.1 0.0 1.6 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain DUF745 PF05335.13 EDP42872.1 - 0.012 15.4 0.4 0.023 14.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Spc7 PF08317.11 EDP42872.1 - 0.012 14.5 0.3 0.028 13.3 0.3 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein PKcGMP_CC PF16808.5 EDP42872.1 - 0.087 12.7 1.9 0.42 10.5 0.2 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CC2-LZ PF16516.5 EDP42872.1 - 0.26 11.7 8.2 1.8 9.0 0.4 3.1 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Fez1 PF06818.15 EDP42872.1 - 0.49 10.8 4.8 0.19 12.1 2.1 1.6 2 0 0 2 2 2 0 Fez1 HMMR_N PF15905.5 EDP42872.1 - 0.52 9.7 3.9 0.31 10.5 0.4 2.0 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal L51_S25_CI-B8 PF05047.16 EDP42873.1 - 7.5e-05 22.6 0.1 0.00021 21.1 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain eRF1_2 PF03464.15 EDP42874.1 - 3.9e-44 150.2 0.0 6.7e-44 149.4 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EDP42874.1 - 2.7e-39 134.2 0.2 5.8e-39 133.1 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EDP42874.1 - 2e-19 69.9 0.0 3.1e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EDP42874.1 - 2.6e-10 40.7 0.0 4.5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EDP42874.1 - 5.6e-08 33.1 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 DUF3440 PF11922.8 EDP42874.1 - 0.045 13.4 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) Sec16_C PF12931.7 EDP42876.1 - 1.2e-79 268.1 0.0 1.6e-79 267.7 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EDP42876.1 - 1.3e-21 77.4 0.0 4e-21 75.8 0.0 2.0 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Arf PF00025.21 EDP42877.1 - 2.1e-70 235.7 0.0 2.3e-70 235.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP42877.1 - 1.7e-14 54.1 0.0 2.3e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDP42877.1 - 1.1e-12 47.9 0.0 1.2e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDP42877.1 - 6.7e-11 41.9 0.0 8.5e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDP42877.1 - 8.1e-11 41.7 0.1 2.4e-06 27.0 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDP42877.1 - 1.1e-08 34.7 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDP42877.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EDP42877.1 - 0.042 13.4 0.1 0.23 11.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GATA PF00320.27 EDP42878.1 - 4.8e-17 61.3 1.1 1.2e-16 60.1 1.1 1.7 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EDP42878.1 - 4.9e-12 45.5 1.3 1.2e-11 44.2 1.3 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ArfGap PF01412.18 EDP42878.1 - 0.012 15.7 0.1 0.032 14.3 0.1 1.7 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf ABC_tran PF00005.27 EDP42879.1 - 8.7e-36 123.4 0.0 4.5e-35 121.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EDP42879.1 - 1.1e-35 123.6 6.0 1.5e-35 123.2 6.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDP42879.1 - 2.9e-06 26.9 0.1 0.0052 16.2 0.0 3.0 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA PF00004.29 EDP42879.1 - 0.00014 22.3 0.0 0.0013 19.2 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EDP42879.1 - 0.00073 20.0 0.0 0.0027 18.1 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 EDP42879.1 - 0.0012 18.7 0.9 0.0027 17.5 0.0 1.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 EDP42879.1 - 0.0014 18.6 0.0 0.024 14.5 0.0 2.3 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EDP42879.1 - 0.0035 17.3 0.0 0.027 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDP42879.1 - 0.0061 16.8 0.1 0.054 13.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDP42879.1 - 0.0097 15.6 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EDP42879.1 - 0.044 13.4 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 EDP42879.1 - 0.055 13.3 2.0 0.13 12.1 2.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_14 PF13173.6 EDP42879.1 - 0.058 13.4 0.1 0.7 9.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EDP42879.1 - 0.072 13.0 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 EDP42879.1 - 0.077 13.5 0.4 0.19 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EDP42879.1 - 0.089 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 EDP42879.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EDP42879.1 - 0.16 12.1 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 EDP42879.1 - 0.63 10.3 4.3 0.41 10.9 0.2 2.8 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit PAP2 PF01569.21 EDP42880.1 - 3.5e-30 104.6 0.5 3.5e-30 104.6 0.5 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EDP42880.1 - 0.0012 18.6 9.8 0.22 11.2 3.6 2.8 2 1 0 2 2 2 2 PAP2 superfamily RDD PF06271.12 EDP42880.1 - 0.23 11.7 3.9 0.35 11.1 0.1 2.6 3 0 0 3 3 3 0 RDD family Topoisom_bac PF01131.20 EDP42882.1 - 1.1e-98 330.9 0.0 1.6e-98 330.4 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EDP42882.1 - 3.4e-09 36.9 0.1 1e-08 35.3 0.0 1.9 2 0 0 2 2 2 1 Toprim domain zf-GRF PF06839.12 EDP42882.1 - 2.7e-08 33.8 20.0 0.00011 22.2 3.1 2.8 2 0 0 2 2 2 2 GRF zinc finger DUF730 PF05325.11 EDP42882.1 - 0.18 11.8 5.8 0.3 11.1 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF730) HLH PF00010.26 EDP42884.1 - 4.5e-09 36.1 0.0 1.2e-08 34.8 0.0 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.13 EDP42884.1 - 0.64 10.0 10.2 0.73 9.8 10.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HAMP PF00672.25 EDP42885.1 - 8.8e-37 125.3 21.5 2.4e-07 31.0 0.2 9.1 8 2 0 8 8 8 6 HAMP domain HATPase_c PF02518.26 EDP42885.1 - 6.3e-27 94.3 0.0 2.6e-26 92.3 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EDP42885.1 - 3.5e-26 91.6 0.5 4.2e-25 88.1 0.8 2.5 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EDP42885.1 - 8.7e-17 60.9 1.9 7.8e-16 57.9 0.4 3.7 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain DUF1843 PF08898.10 EDP42885.1 - 0.00068 20.1 0.7 12 6.5 0.1 5.4 5 0 0 5 5 5 1 Domain of unknown function (DUF1843) TMF_TATA_bd PF12325.8 EDP42885.1 - 0.027 14.7 4.2 7.8 6.8 0.0 4.1 5 0 0 5 5 5 0 TATA element modulatory factor 1 TATA binding PhoR PF11808.8 EDP42885.1 - 0.039 14.4 0.0 44 4.6 0.0 3.9 4 0 0 4 4 4 0 Phosphate regulon sensor protein PhoR DUF3829 PF12889.7 EDP42885.1 - 0.17 11.4 1.4 5.1 6.5 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) HrpB7 PF09486.10 EDP42885.1 - 0.61 10.5 3.2 1.2e+02 3.0 0.0 4.1 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) Rab5-bind PF09311.11 EDP42885.1 - 0.92 8.8 13.8 5.1 6.4 0.1 5.1 3 2 3 6 6 6 0 Rabaptin-like protein SpoIIID PF12116.8 EDP42885.1 - 1 9.5 3.8 63 3.8 0.0 4.7 6 0 0 6 6 6 0 Stage III sporulation protein D CENP-F_leu_zip PF10473.9 EDP42885.1 - 3.1 7.8 11.3 31 4.6 0.1 5.2 5 0 0 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TFIIS_M PF07500.14 EDP42886.1 - 2.8e-23 82.5 0.0 5.4e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 EDP42886.1 - 3e-11 43.4 0.0 6.2e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 SPOC domain PHD PF00628.29 EDP42886.1 - 1.7e-09 37.4 11.4 2.9e-09 36.7 11.4 1.4 1 0 0 1 1 1 1 PHD-finger ADK_lid PF05191.14 EDP42886.1 - 6.4 6.8 7.4 1 9.4 3.3 1.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid Porin_3 PF01459.22 EDP42887.1 - 3.9e-73 246.2 0.2 4.6e-73 246.0 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin MBOAT_2 PF13813.6 EDP42888.1 - 2e-05 24.7 4.9 2e-05 24.7 4.9 3.2 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family ANAPC4_WD40 PF12894.7 EDP42889.1 - 0.094 13.0 0.0 2.4 8.5 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Phage_Gp19 PF09355.10 EDP42889.1 - 0.15 12.5 0.1 0.47 10.9 0.1 1.8 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 WD40 PF00400.32 EDP42889.1 - 0.15 13.0 0.0 0.15 13.0 0.0 5.2 5 0 0 5 5 5 0 WD domain, G-beta repeat Histone PF00125.24 EDP42890.1 - 2.5e-19 69.9 0.0 3.5e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EDP42890.1 - 2.5e-09 36.7 0.0 6.2e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EDP42890.1 - 0.0092 16.2 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.25 EDP42891.1 - 8.5e-15 54.8 0.0 9.6e-15 54.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42891.1 - 1.1e-05 24.9 0.0 1.3e-05 24.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EDP42892.1 - 8.8e-15 54.8 0.0 1.4e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42892.1 - 1.7e-12 47.2 0.0 2.2e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Glycos_transf_2 PF00535.26 EDP42893.1 - 8.9e-20 71.2 0.0 2.1e-19 70.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EDP42893.1 - 1.9e-07 31.2 0.2 0.00013 22.0 0.1 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EDP42893.1 - 0.0031 17.0 0.0 0.0049 16.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 PAH PF02671.21 EDP42894.1 - 6.3e-25 87.1 5.5 3.6e-16 59.0 4.5 2.2 2 0 0 2 2 2 2 Paired amphipathic helix repeat Sin3a_C PF16879.5 EDP42895.1 - 6.5e-66 223.0 0.0 1.3e-65 221.9 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein DNA_pol_phi PF04931.13 EDP42895.1 - 0.06 11.4 4.5 0.12 10.4 4.5 1.4 1 0 0 1 1 1 0 DNA polymerase phi eIF-1a PF01176.19 EDP42896.1 - 1.2e-20 73.1 0.0 1.6e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 YIF1 PF03878.15 EDP42897.1 - 2.3e-88 295.8 0.1 3.8e-88 295.1 0.1 1.3 1 1 0 1 1 1 1 YIF1 FAE1_CUT1_RppA PF08392.12 EDP42897.1 - 0.2 10.9 0.0 0.31 10.3 0.0 1.1 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein RNA_pol_Rpb2_1 PF04563.15 EDP42898.1 - 7.8e-34 117.0 0.0 1.2e-33 116.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EDP42898.1 - 1.6e-27 95.4 0.0 3.7e-27 94.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EDP42898.1 - 2.1e-22 79.7 0.0 2.9e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 EDP42898.1 - 2e-20 72.5 0.0 4.6e-20 71.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain Arena_nucleocap PF00843.17 EDP42898.1 - 0.21 10.5 0.0 0.36 9.7 0.0 1.3 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain RNA_pol_Rpb2_6 PF00562.28 EDP42899.1 - 3.6e-100 335.8 0.0 1.2e-99 334.1 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 EDP42899.1 - 1e-17 64.3 0.1 8.5e-15 54.9 0.1 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Nfu_N PF08712.11 EDP42900.1 - 2.6e-31 107.5 0.0 5.5e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EDP42900.1 - 1.7e-26 92.1 0.1 3e-26 91.3 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Peptidase_S10 PF00450.22 EDP42902.1 - 9.3e-30 104.4 0.0 1.2e-29 104.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase TPR_16 PF13432.6 EDP42902.1 - 0.02 15.5 0.1 0.048 14.3 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Peptidase_S10 PF00450.22 EDP42903.1 - 5.8e-40 138.0 0.0 7.9e-40 137.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF4853 PF16145.5 EDP42903.1 - 0.16 12.1 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) NOC3p PF07540.11 EDP42904.1 - 4.5e-30 104.0 0.0 1.3e-29 102.5 0.0 1.9 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 EDP42904.1 - 3.9e-11 43.3 0.3 3.9e-11 43.3 0.3 3.0 3 2 0 3 3 3 1 CBF/Mak21 family PRAS PF15798.5 EDP42904.1 - 0.033 14.8 1.1 0.033 14.8 1.1 3.3 3 0 0 3 3 3 0 Proline-rich AKT1 substrate 1 RRM_1 PF00076.22 EDP42905.1 - 7.5e-82 269.2 3.0 1e-21 76.5 0.4 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EDP42905.1 - 1.4e-27 95.6 0.3 4e-26 91.0 0.3 2.8 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EDP42905.1 - 2e-12 46.8 0.1 0.0015 18.1 0.0 4.2 1 1 3 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP42905.1 - 6.3e-06 26.0 0.0 0.00049 19.9 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EDP42905.1 - 0.00038 20.5 0.2 14 5.9 0.0 4.8 4 2 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EDP42905.1 - 0.005 16.8 1.3 34 4.5 0.0 4.0 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EDP42905.1 - 0.0059 16.6 0.3 20 5.3 0.1 4.3 4 0 0 4 4 4 0 Limkain b1 RRM_3 PF08777.11 EDP42905.1 - 0.026 14.6 5.7 2.1 8.4 2.0 3.3 4 0 0 4 4 4 0 RNA binding motif Recombinase PF07508.13 EDP42905.1 - 0.13 12.7 0.1 0.39 11.1 0.1 1.8 1 0 0 1 1 1 0 Recombinase DbpA PF03880.15 EDP42905.1 - 0.17 11.9 0.0 24 5.0 0.0 3.6 4 0 0 4 4 4 0 DbpA RNA binding domain GrpE PF01025.19 EDP42906.1 - 1.5e-42 145.1 0.2 1.8e-42 144.8 0.2 1.1 1 0 0 1 1 1 1 GrpE TB2_DP1_HVA22 PF03134.19 EDP42907.1 - 2.7e-29 100.9 8.5 3.4e-29 100.6 8.5 1.1 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Hum_adeno_E3A PF05393.11 EDP42907.1 - 4.9 7.2 5.7 0.32 11.0 1.0 1.5 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein KH_8 PF17903.1 EDP42908.1 - 6.8e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EDP42908.1 - 0.022 14.5 0.3 0.05 13.4 0.3 1.6 1 0 0 1 1 1 0 KH domain MitMem_reg PF13012.6 EDP42910.1 - 8.3e-35 119.6 0.3 1.4e-34 118.8 0.3 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EDP42910.1 - 6.4e-30 103.6 0.0 1.2e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RIBIOP_C PF04950.12 EDP42911.1 - 1.2e-41 143.1 0.0 1.2e-41 143.1 0.0 2.1 2 1 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EDP42911.1 - 9.2e-18 64.1 0.2 1e-16 60.8 0.0 2.5 2 0 0 2 2 2 1 AARP2CN (NUC121) domain DUF3793 PF12672.7 EDP42911.1 - 0.019 15.0 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) RIBIOP_C PF04950.12 EDP42912.1 - 1.1e-49 169.4 0.0 1.3e-49 169.2 0.0 1.1 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal ORMDL PF04061.14 EDP42913.1 - 1.9e-53 179.9 2.2 2.2e-53 179.7 2.2 1.0 1 0 0 1 1 1 1 ORMDL family DUF2229 PF09989.9 EDP42914.1 - 0.13 11.9 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) SPT6_acidic PF14632.6 EDP42914.1 - 1.2 9.7 14.2 2.5 8.7 0.7 2.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 LNS2 PF08235.13 EDP42915.1 - 2.9e-101 337.7 0.0 4e-101 337.2 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EDP42915.1 - 9.2e-29 99.4 0.1 8.7e-28 96.3 0.1 2.2 1 1 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 EDP42915.1 - 2.7e-08 33.9 0.0 6.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF4012 PF13196.6 EDP42915.1 - 0.087 13.3 0.0 12 6.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4012) HAT_KAT11 PF08214.11 EDP42916.1 - 2.5e-27 96.1 0.0 4.3e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Histone acetylation protein Tryp_inh PF17983.1 EDP42916.1 - 1.8 8.7 6.1 8.3 6.6 0.1 3.1 3 0 0 3 3 3 0 Trypsin inhibitors 1,2 and 3 FKBP_C PF00254.28 EDP42917.1 - 2e-33 114.5 0.0 2.2e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RCC1 PF00415.18 EDP42918.1 - 2.7e-55 184.8 4.1 2.1e-11 44.3 0.2 7.6 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EDP42918.1 - 1.1e-35 120.6 35.2 1.6e-08 34.1 0.2 8.3 9 0 0 9 9 9 6 Regulator of chromosome condensation (RCC1) repeat Reg_prop PF07494.11 EDP42918.1 - 0.047 13.9 0.1 16 6.1 0.1 4.0 4 0 0 4 4 4 0 Two component regulator propeller Linker_histone PF00538.19 EDP42919.1 - 2.9e-18 66.0 0.0 2.9e-18 66.0 0.0 2.3 2 1 0 2 2 2 1 linker histone H1 and H5 family SOG2 PF10428.9 EDP42919.1 - 0.75 8.9 18.8 0.84 8.8 18.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 EDP42919.1 - 0.82 9.2 18.5 0.99 9.0 18.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.9 EDP42919.1 - 3 6.3 17.8 3.2 6.2 17.8 1.0 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 EDP42919.1 - 3.3 6.0 20.2 4 5.7 20.2 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 EDP42919.1 - 3.8 6.4 10.8 4.5 6.2 10.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FSA_C PF10479.9 EDP42919.1 - 6.4 4.8 18.3 7.2 4.6 18.3 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus tRNA-synt_1 PF00133.22 EDP42920.1 - 2.2e-212 706.6 0.0 2.2e-211 703.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDP42920.1 - 1.7e-33 115.7 0.0 3.1e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDP42920.1 - 1.3e-14 53.8 0.5 2e-06 26.8 0.1 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EDP42920.1 - 2.8e-09 36.7 0.2 1.2e-05 24.9 0.1 2.5 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EDP42920.1 - 0.0026 17.1 2.3 0.57 9.5 0.0 3.1 4 0 0 4 4 4 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1b PF00579.25 EDP42920.1 - 0.11 11.8 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) IKI3 PF04762.12 EDP42921.1 - 4.8e-231 769.5 0.0 1e-230 768.5 0.0 1.5 2 0 0 2 2 2 1 IKI3 family ANAPC4_WD40 PF12894.7 EDP42921.1 - 0.00017 21.8 0.0 0.46 10.8 0.0 4.3 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Se-cys_synth_N PF12390.8 EDP42921.1 - 0.0055 16.9 1.9 0.0093 16.2 0.0 2.4 2 0 0 2 2 2 1 Selenocysteine synthase N terminal WD40 PF00400.32 EDP42921.1 - 0.018 15.9 0.7 16 6.6 0.2 4.9 4 0 0 4 4 4 0 WD domain, G-beta repeat DUF3885 PF13021.6 EDP42921.1 - 0.099 12.8 0.1 0.29 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) CtIP_N PF10482.9 EDP42921.1 - 0.29 11.2 2.8 0.24 11.4 0.1 2.2 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Spt5_N PF11942.8 EDP42921.1 - 2.3 9.2 6.1 10 7.2 6.1 2.1 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal ECH_1 PF00378.20 EDP42922.1 - 5.6e-30 104.5 0.0 9.4e-30 103.7 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDP42922.1 - 2e-19 70.3 0.0 2.4e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Gly_acyl_tr_C PF08444.10 EDP42923.1 - 0.017 15.4 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region MFS_1 PF07690.16 EDP42924.1 - 3.9e-42 144.4 28.9 3.9e-42 144.4 28.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP42924.1 - 4.2e-18 65.5 7.0 4.2e-18 65.5 7.0 2.5 1 1 1 2 2 2 1 Sugar (and other) transporter ABC1 PF03109.16 EDP42925.1 - 1.1e-28 99.7 0.0 2e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EDP42925.1 - 0.009 15.4 0.0 4.1 6.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 EDP42925.1 - 0.036 13.7 0.0 0.092 12.3 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Spindle_Spc25 PF08234.12 EDP42926.1 - 5.6e-16 58.5 0.0 1.1e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 EDP42926.1 - 0.00016 20.7 7.7 0.00023 20.2 7.7 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ERM PF00769.19 EDP42926.1 - 0.0012 18.7 10.3 0.0016 18.3 10.3 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family SHE3 PF17078.5 EDP42926.1 - 0.0052 16.5 4.7 0.01 15.6 4.7 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 SKA2 PF16740.5 EDP42926.1 - 0.0059 16.4 12.4 0.058 13.2 5.9 2.4 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 2 V_ATPase_I PF01496.19 EDP42926.1 - 0.0069 14.4 4.5 0.0084 14.1 4.5 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family FapA PF03961.13 EDP42926.1 - 0.035 12.7 5.0 0.054 12.1 5.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TssR PF17643.1 EDP42926.1 - 0.052 11.5 0.1 0.065 11.2 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssR CALCOCO1 PF07888.11 EDP42926.1 - 0.052 12.4 16.3 0.072 11.9 16.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Protein_K PF12283.8 EDP42926.1 - 0.082 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage protein K Fmp27_WPPW PF10359.9 EDP42926.1 - 0.14 11.0 7.0 0.19 10.6 7.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Golgin_A5 PF09787.9 EDP42926.1 - 0.35 10.3 13.9 0.54 9.7 13.9 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 EDP42926.1 - 0.37 10.8 13.1 0.65 10.0 12.6 1.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HIP1_clath_bdg PF16515.5 EDP42926.1 - 1.1 10.0 18.8 4.4 8.0 5.4 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 EDP42926.1 - 1.4 8.2 10.9 2.1 7.6 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EDP42926.1 - 1.8 8.6 8.9 3.4 7.7 3.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 EDP42926.1 - 1.9 9.1 18.5 2.9 8.4 16.7 2.1 2 1 1 3 3 2 0 Apg6 coiled-coil region UPF0242 PF06785.11 EDP42926.1 - 2.3 8.3 10.8 3.3 7.8 10.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF883 PF05957.13 EDP42926.1 - 3.2 8.4 16.7 0.46 11.1 6.9 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) AAA_13 PF13166.6 EDP42926.1 - 3.7 6.1 9.4 10 4.6 9.4 1.7 1 1 0 1 1 1 0 AAA domain DUF4200 PF13863.6 EDP42926.1 - 4.5 7.7 18.3 12 6.3 18.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Seryl_tRNA_N PF02403.22 EDP42926.1 - 4.9 7.4 13.8 4.4 7.6 7.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HAUS-augmin3 PF14932.6 EDP42926.1 - 7 6.1 13.2 16 5.0 11.8 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Pkinase PF00069.25 EDP42927.1 - 1.1e-61 208.5 0.0 4.2e-61 206.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42927.1 - 1.4e-27 96.6 0.0 6.9e-19 68.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDP42927.1 - 0.00067 19.1 0.0 0.029 13.7 0.0 2.5 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.14 EDP42927.1 - 0.0073 15.7 0.1 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDP42927.1 - 0.017 14.1 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EDP42927.1 - 0.033 14.1 1.9 0.56 10.1 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 EDP42927.1 - 0.14 12.9 0.3 0.46 11.2 0.0 2.1 2 1 0 2 2 2 0 Protein kinase C terminal domain MRP-L47 PF06984.13 EDP42927.1 - 0.21 11.7 1.0 33 4.7 0.0 3.3 3 0 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) MAPEG PF01124.18 EDP42928.1 - 6.7e-26 90.7 5.0 7.7e-26 90.5 5.0 1.0 1 0 0 1 1 1 1 MAPEG family SirB PF04247.12 EDP42928.1 - 0.052 13.6 0.1 0.071 13.2 0.1 1.2 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB HECT PF00632.25 EDP42929.1 - 3.7e-100 335.4 0.0 4.7e-100 335.0 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PAXIP1_C PF15364.6 EDP42929.1 - 0.015 15.6 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein Autoind_bind PF03472.15 EDP42929.1 - 0.036 13.5 0.0 0.075 12.5 0.0 1.5 1 0 0 1 1 1 0 Autoinducer binding domain zf-UBR PF02207.20 EDP42930.1 - 1.4e-15 57.1 14.3 3.2e-15 56.0 14.3 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EDP42930.1 - 2.3e-07 30.5 0.0 8.1e-07 28.7 0.0 2.0 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 EDP42930.1 - 0.014 15.7 1.4 0.014 15.7 1.4 3.6 3 1 0 3 3 3 0 Ring finger domain TRAPP PF04051.16 EDP42931.1 - 1.3e-30 106.0 0.0 1.5e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Bromodomain PF00439.25 EDP42932.1 - 1.8e-31 108.0 0.4 1.1e-15 57.4 0.0 3.2 2 1 0 2 2 2 2 Bromodomain BET PF17035.5 EDP42932.1 - 8.4e-20 70.7 0.8 8.4e-20 70.7 0.8 1.9 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation zf-C2H2 PF00096.26 EDP42933.1 - 9.9e-07 28.9 0.8 0.029 14.8 0.1 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP42933.1 - 1.1e-06 29.0 1.6 0.0048 17.6 0.1 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDP42933.1 - 7.1e-05 23.0 1.2 0.0095 16.2 0.6 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EDP42933.1 - 0.00013 22.1 1.0 0.0079 16.5 1.0 2.1 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EDP42933.1 - 0.00062 19.7 0.7 0.068 13.2 0.0 2.3 1 1 1 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EDP42933.1 - 0.0045 17.3 0.3 0.65 10.4 0.2 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 EDP42933.1 - 0.0095 15.8 3.0 0.56 10.1 0.3 2.1 1 1 1 2 2 2 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_2 PF13465.6 EDP42933.1 - 0.11 13.0 7.0 0.22 12.0 0.7 2.7 3 0 0 3 3 3 0 Zinc-finger double domain Abhydro_lipase PF04083.16 EDP42935.1 - 1.2e-13 50.4 0.0 2.7e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EDP42935.1 - 2.7e-10 40.3 0.1 5.8e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDP42935.1 - 0.00026 20.3 0.0 0.00048 19.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PUF PF00806.19 EDP42936.1 - 5.8e-44 145.4 4.5 1.8e-08 33.6 0.1 6.3 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat FlgD_ig PF13860.6 EDP42936.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 FlgD Ig-like domain PUF PF00806.19 EDP42937.1 - 1.1e-19 68.9 0.1 2.1e-08 33.4 0.1 2.3 2 0 0 2 2 2 2 Pumilio-family RNA binding repeat RFC1 PF08519.12 EDP42939.1 - 1.3e-47 161.9 0.0 2.3e-47 161.1 0.0 1.4 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EDP42939.1 - 9.1e-13 48.4 0.0 1.6e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EDP42939.1 - 3.4e-07 30.8 0.0 7.2e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EDP42939.1 - 1.5e-05 25.0 0.0 4.1e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 EDP42939.1 - 0.0015 18.3 0.0 0.0089 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDP42939.1 - 0.0019 18.2 0.0 0.0048 16.8 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EDP42939.1 - 0.0039 17.6 0.3 0.016 15.6 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EDP42939.1 - 0.027 14.7 0.1 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain SAGA-Tad1 PF12767.7 EDP42939.1 - 0.037 13.8 0.1 0.57 9.9 0.0 2.5 2 1 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit AAA_22 PF13401.6 EDP42939.1 - 0.05 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain 5_3_exonuc PF01367.20 EDP42939.1 - 0.053 14.1 0.0 1.4 9.6 0.0 2.7 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold NTPase_1 PF03266.15 EDP42939.1 - 0.072 13.0 0.0 0.32 10.9 0.0 2.0 3 0 0 3 3 3 0 NTPase AAA_14 PF13173.6 EDP42939.1 - 0.074 13.1 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain DNA_pol3_delta PF06144.13 EDP42939.1 - 0.095 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_33 PF13671.6 EDP42939.1 - 0.13 12.4 0.0 0.13 12.4 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EDP42939.1 - 0.15 12.4 0.1 0.44 10.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF3915 PF13054.6 EDP42939.1 - 0.29 11.1 0.9 0.6 10.1 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Rgp1 PF08737.10 EDP42940.1 - 1.8e-75 254.7 0.0 4.8e-73 246.7 0.0 2.1 1 1 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 EDP42940.1 - 3.5e-05 24.3 0.0 0.078 13.4 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EDP42940.1 - 0.00011 22.3 0.0 0.00028 21.0 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EDP42940.1 - 0.0036 16.9 0.0 0.13 11.8 0.0 2.2 2 0 0 2 2 2 1 SpoOM protein Sec20 PF03908.13 EDP42941.1 - 2.4e-15 56.2 1.1 2.4e-15 56.2 1.1 2.4 2 0 0 2 2 2 1 Sec20 adh_short PF00106.25 EDP42942.1 - 1.8e-29 102.6 0.0 2.8e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP42942.1 - 4.4e-21 75.5 0.0 7.2e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP42942.1 - 1.2e-08 35.1 0.0 2.6e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EDP42942.1 - 0.0076 15.7 0.1 0.016 14.5 0.1 1.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EDP42942.1 - 0.1 12.0 0.1 0.2 11.1 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Arm PF00514.23 EDP42943.1 - 4.1e-61 201.3 22.8 8e-12 44.8 0.2 9.7 10 1 0 10 10 10 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EDP42943.1 - 2.1e-13 50.4 9.5 0.049 14.2 0.2 8.1 6 1 2 8 8 8 3 HEAT-like repeat HEAT_2 PF13646.6 EDP42943.1 - 9.1e-12 45.2 5.3 0.087 13.2 0.1 6.0 2 2 2 5 5 5 4 HEAT repeats HEAT PF02985.22 EDP42943.1 - 2.5e-08 33.5 11.9 3.9 8.0 0.0 8.1 8 0 0 8 8 8 1 HEAT repeat KAP PF05804.12 EDP42943.1 - 2.2e-06 26.2 0.1 3.2e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EDP42943.1 - 1.2e-05 24.7 2.7 0.02 14.2 0.3 3.6 1 1 1 3 3 3 2 V-ATPase subunit H Adaptin_N PF01602.20 EDP42943.1 - 3.1e-05 22.7 7.4 0.00041 19.0 7.4 2.4 1 1 0 1 1 1 1 Adaptin N terminal region Arm_2 PF04826.13 EDP42943.1 - 3.9e-05 23.2 6.8 0.092 12.2 0.0 3.4 2 1 1 3 3 3 2 Armadillo-like Cnd1 PF12717.7 EDP42943.1 - 0.00047 20.2 4.0 0.071 13.2 0.3 3.3 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 EDP42943.1 - 0.0057 16.8 1.7 45 4.2 0.0 4.4 3 1 2 5 5 5 0 V-ATPase subunit H HEAT_PBS PF03130.16 EDP42943.1 - 0.028 15.1 1.5 1.9e+02 3.2 0.0 5.4 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat UNC45-central PF11701.8 EDP42943.1 - 0.028 14.4 3.1 2.2 8.2 0.2 3.7 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central YqfD PF06898.11 EDP42943.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Atx10homo_assoc PF09759.9 EDP42943.1 - 0.43 10.6 2.4 2.3 8.3 0.0 3.4 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain CTNNBL PF08216.11 EDP42943.1 - 0.57 10.4 2.8 29 4.9 0.0 3.5 3 1 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear FF PF01846.19 EDP42944.1 - 1.4e-16 60.3 10.1 9.1e-07 29.0 0.0 6.7 6 1 0 6 6 6 3 FF domain RhoGAP-FF1 PF16512.5 EDP42944.1 - 0.002 18.7 8.7 0.011 16.4 1.4 3.4 2 1 0 2 2 2 2 p190-A and -B Rho GAPs FF domain WW PF00397.26 EDP42944.1 - 0.21 11.7 0.6 0.48 10.5 0.6 1.6 1 0 0 1 1 1 0 WW domain Abhydrolase_1 PF00561.20 EDP42945.1 - 4e-12 46.3 0.0 1.1e-11 44.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EDP42945.1 - 0.0082 16.2 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein TIP120 PF08623.10 EDP42946.1 - 4.2e-41 140.5 0.8 4.2e-41 140.5 0.8 2.4 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) RTP1_C1 PF10363.9 EDP42946.1 - 3.4e-08 33.7 8.7 0.73 10.0 0.1 7.2 7 2 0 7 7 7 3 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EDP42946.1 - 9.2e-07 29.2 34.1 8.6e-05 23.0 0.5 9.9 8 1 1 9 9 9 2 HEAT-like repeat RIX1 PF08167.12 EDP42946.1 - 0.00017 21.4 9.3 1.6 8.4 0.0 6.6 5 3 1 6 6 6 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 EDP42946.1 - 0.0058 16.7 0.6 20 5.2 0.0 4.2 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 EDP42946.1 - 0.017 15.5 1.5 0.31 11.4 0.0 3.8 3 1 1 4 4 4 0 TAF6 C-terminal HEAT repeat domain Collagen_mid PF15984.5 EDP42946.1 - 0.37 10.5 3.4 13 5.5 0.2 3.0 3 0 0 3 3 3 0 Bacterial collagen, middle region HEAT PF02985.22 EDP42946.1 - 2.3 8.7 25.9 2.1 8.8 0.0 9.0 11 0 0 11 11 11 0 HEAT repeat Adaptin_N PF01602.20 EDP42946.1 - 2.6 6.5 8.0 8.6 4.8 0.0 4.4 4 1 0 4 4 4 0 Adaptin N terminal region PQQ_3 PF13570.6 EDP42947.1 - 0.022 15.3 0.1 9 6.9 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain Ysc84 PF04366.12 EDP42948.1 - 1.2e-27 96.2 0.1 4.1e-26 91.2 0.1 2.1 1 1 0 1 1 1 1 Las17-binding protein actin regulator RhoGEF PF00621.20 EDP42949.1 - 5.8e-10 39.7 0.4 1.4e-09 38.5 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain EssA PF10661.9 EDP42949.1 - 0.55 10.1 1.9 1 9.2 1.9 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA TSC22 PF01166.18 EDP42949.1 - 5.9 7.3 10.2 0.25 11.7 0.3 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family CHS5_N PF16892.5 EDP42950.1 - 2.5e-24 84.9 0.1 4.4e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus fn3_2 PF16893.5 EDP42950.1 - 6.7e-17 61.4 0.0 1.8e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain PTCB-BRCT PF12738.7 EDP42950.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EDP42950.1 - 2.9e-05 24.4 0.0 6.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDP42950.1 - 0.0015 18.9 0.0 0.004 17.5 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3006 PF11213.8 EDP42950.1 - 0.031 14.5 0.0 0.093 13.0 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) Creatinase_N_2 PF16189.5 EDP42952.1 - 7.9e-43 146.3 0.1 8.7e-42 143.0 0.0 2.3 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EDP42952.1 - 2.1e-37 128.8 0.0 4.6e-37 127.7 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EDP42952.1 - 9.3e-21 74.9 0.3 3.5e-14 53.6 0.0 2.6 2 1 1 3 3 3 2 Creatinase/Prolidase N-terminal domain TPR_2 PF07719.17 EDP42953.1 - 5.3e-10 38.6 9.6 0.00073 19.5 1.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDP42953.1 - 3.5e-06 26.6 8.1 0.001 18.8 1.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP42953.1 - 4.4e-06 27.1 6.8 0.00094 19.6 1.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDP42953.1 - 0.00013 21.9 2.5 1.2 9.2 0.0 3.4 1 1 2 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 EDP42953.1 - 0.0028 18.3 8.2 0.26 11.9 2.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP42953.1 - 0.003 18.2 11.3 0.52 11.3 0.2 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP42953.1 - 0.0049 17.1 5.1 0.027 14.7 4.4 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EDP42953.1 - 0.13 12.0 8.0 1.1 8.9 1.5 3.2 2 1 1 3 3 3 0 TPR repeat TPR_12 PF13424.6 EDP42953.1 - 0.28 11.5 4.6 0.59 10.5 0.2 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP42953.1 - 1.1 9.5 5.8 1.6 8.9 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 EDP42954.1 - 1.4e-41 142.6 0.0 1.1e-22 80.7 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EDP42954.1 - 4.2e-14 52.5 0.0 1.5e-12 47.3 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EDP42954.1 - 0.045 13.7 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP42954.1 - 0.093 11.5 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EDP42954.1 - 0.1 11.9 0.0 0.53 9.5 0.0 1.9 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 EDP42954.1 - 0.1 12.2 0.0 0.32 10.6 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDP42956.1 - 2.8e-10 40.5 0.2 1.4e-05 25.1 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EDP42956.1 - 4.2e-09 36.2 0.0 4.8e-09 36.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EDP42956.1 - 1.9e-08 33.9 0.0 8.7e-06 25.2 0.0 2.0 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EDP42956.1 - 1.2e-07 31.5 0.0 0.00084 19.0 0.0 2.1 2 0 0 2 2 2 2 RIO1 family Pkinase_Tyr PF07714.17 EDP42956.1 - 7.1e-06 25.5 0.0 8.2e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 EDP42956.1 - 0.00013 21.4 0.1 0.00024 20.5 0.0 1.4 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 EDP42956.1 - 0.0036 16.9 0.0 0.041 13.5 0.0 1.8 1 1 1 2 2 2 1 Choline/ethanolamine kinase eIF-3_zeta PF05091.12 EDP42958.1 - 3.7e-191 636.6 0.0 4.3e-191 636.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) VID27 PF08553.10 EDP42959.1 - 9.3e-164 544.6 0.0 1.2e-163 544.3 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 EDP42959.1 - 2.8e-18 66.2 1.7 1.3e-17 64.1 2.3 1.9 2 0 0 2 2 2 1 VID27 PH-like domain AAA PF00004.29 EDP42960.1 - 7.7e-53 178.4 0.0 6e-39 133.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 EDP42960.1 - 1.3e-10 40.9 0.3 6.5e-09 35.4 0.1 2.8 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_lid_3 PF17862.1 EDP42960.1 - 1.4e-09 37.6 0.0 3.5e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDP42960.1 - 2.8e-09 37.4 0.0 0.00033 20.9 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EDP42960.1 - 7.2e-09 36.2 0.1 0.006 17.0 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 EDP42960.1 - 2.3e-08 34.4 0.0 3.7e-05 23.9 0.0 3.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDP42960.1 - 3.6e-08 33.5 0.3 0.0013 18.8 0.1 3.1 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EDP42960.1 - 1.3e-07 31.2 0.0 0.0063 15.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 EDP42960.1 - 1.7e-07 31.1 0.2 0.031 14.0 0.1 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDP42960.1 - 1.6e-06 27.7 0.4 0.0043 16.5 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDP42960.1 - 4.8e-06 27.1 0.0 0.13 12.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EDP42960.1 - 6e-06 26.5 0.0 0.15 12.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EDP42960.1 - 1.1e-05 25.2 0.0 0.038 13.7 0.0 2.8 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EDP42960.1 - 2.5e-05 24.1 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EDP42960.1 - 2.6e-05 24.6 0.0 0.098 13.1 0.0 2.5 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 EDP42960.1 - 2.8e-05 24.1 0.2 0.048 13.6 0.0 3.0 2 1 1 3 3 3 1 NACHT domain AAA_30 PF13604.6 EDP42960.1 - 6e-05 22.9 0.0 0.23 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 EDP42960.1 - 0.00012 22.0 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EDP42960.1 - 0.00015 21.4 0.0 0.37 10.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EDP42960.1 - 0.00016 21.2 0.0 0.19 11.2 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein ATPase PF06745.13 EDP42960.1 - 0.00023 20.6 0.1 0.02 14.2 0.1 2.5 2 0 0 2 2 2 1 KaiC TsaE PF02367.17 EDP42960.1 - 0.00026 21.0 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EDP42960.1 - 0.00036 21.0 0.1 0.45 11.0 0.1 2.6 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EDP42960.1 - 0.00055 19.5 1.2 0.046 13.2 0.0 2.7 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_3 PF07726.11 EDP42960.1 - 0.00073 19.4 0.0 0.2 11.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDP42960.1 - 0.00078 19.2 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase_2 PF01637.18 EDP42960.1 - 0.00096 19.1 0.0 14 5.5 0.0 4.0 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EDP42960.1 - 0.0011 18.2 0.0 0.9 8.7 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_14 PF13173.6 EDP42960.1 - 0.0014 18.7 0.0 1 9.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 EDP42960.1 - 0.0014 17.8 0.0 1.6 7.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 EDP42960.1 - 0.0019 18.5 0.3 1.1 9.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EDP42960.1 - 0.0021 18.3 0.0 1.6 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EDP42960.1 - 0.0061 17.0 0.1 1.5 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EDP42960.1 - 0.015 14.6 0.1 5.1 6.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 EDP42960.1 - 0.031 14.3 0.0 4.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DAP3 PF10236.9 EDP42960.1 - 0.075 12.2 0.1 5.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 EDP42960.1 - 0.078 12.7 0.3 5.8 6.7 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 EDP42960.1 - 0.09 12.2 0.0 5.5 6.3 0.0 3.1 3 1 0 3 3 2 0 Bacterial TniB protein Rad17 PF03215.15 EDP42960.1 - 0.091 12.7 0.0 3.1 7.7 0.0 2.8 3 0 0 3 3 3 0 Rad17 P-loop domain CDC48_N PF02359.18 EDP42960.1 - 0.11 12.7 0.0 0.7 10.1 0.0 2.4 2 0 0 2 2 1 0 Cell division protein 48 (CDC48), N-terminal domain PP2C PF00481.21 EDP42961.1 - 4.3e-32 111.8 0.0 6.8e-20 71.8 0.0 3.4 3 0 0 3 3 3 3 Protein phosphatase 2C Cyt-b5 PF00173.28 EDP42962.1 - 6.8e-10 38.9 0.0 1.5e-09 37.8 0.0 1.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain CSN8_PSD8_EIF3K PF10075.9 EDP42963.1 - 3e-26 92.1 0.0 4.9e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EDP42963.1 - 3.5e-05 23.3 0.0 6.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP family HMG_box PF00505.19 EDP42964.1 - 1.1e-20 73.8 8.0 5.9e-11 42.6 0.2 3.1 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDP42964.1 - 4.9e-13 49.5 6.5 1.2e-07 32.2 1.2 2.4 2 0 0 2 2 2 2 HMG-box domain Abhydrolase_2 PF02230.16 EDP42965.1 - 1.7e-09 37.8 0.0 2.2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase MAGE PF01454.19 EDP42966.1 - 3.1e-48 164.3 0.0 3.8e-48 164.0 0.0 1.1 1 0 0 1 1 1 1 MAGE family RNase_T PF00929.24 EDP42967.1 - 0.017 15.7 0.0 0.075 13.6 0.0 2.1 2 1 0 2 2 2 0 Exonuclease CHORD PF04968.12 EDP42967.1 - 0.042 14.6 0.3 0.12 13.1 0.3 1.8 1 0 0 1 1 1 0 CHORD DNA_pol_A_exo1 PF01612.20 EDP42967.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 1 0 1 1 1 0 3'-5' exonuclease adh_short PF00106.25 EDP42968.1 - 7.8e-06 25.5 0.1 0.52 9.7 0.1 3.5 3 1 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDP42968.1 - 0.042 13.4 0.0 2.2 7.8 0.0 2.9 2 1 1 3 3 3 0 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP42968.1 - 0.1 12.5 1.2 1 9.3 0.0 2.3 3 0 0 3 3 3 0 KR domain NUSAP PF16006.5 EDP42968.1 - 0.46 10.2 3.8 0.67 9.7 3.8 1.1 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Dynamin_N PF00350.23 EDP42969.1 - 1.6e-40 139.0 0.0 3e-40 138.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EDP42969.1 - 2.5e-07 30.2 0.3 2.3e-06 27.1 0.0 2.6 3 0 0 3 3 3 1 Dynamin central region MMR_HSR1 PF01926.23 EDP42969.1 - 0.00012 22.1 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF883 PF05957.13 EDP42969.1 - 0.22 12.1 1.2 25 5.5 0.0 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Ribosomal_S3_C PF00189.20 EDP42971.1 - 2.1e-21 76.2 0.6 3.4e-21 75.6 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EDP42971.1 - 5.1e-10 39.0 0.0 9.4e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 KH domain HABP4_PAI-RBP1 PF04774.15 EDP42972.1 - 1.8e-15 57.8 12.6 5.6e-15 56.2 12.6 1.9 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family PI-PLC-X PF00388.19 EDP42973.1 - 3.5e-53 179.1 0.0 5.7e-53 178.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EDP42973.1 - 1.7e-35 121.8 0.1 4e-35 120.6 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EDP42973.1 - 0.0033 17.9 0.1 0.0099 16.3 0.1 1.8 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like PH_14 PF17787.1 EDP42973.1 - 0.012 15.5 0.0 0.055 13.3 0.0 2.0 2 0 0 2 2 2 0 PH domain C2 PF00168.30 EDP42973.1 - 0.016 15.5 0.1 5.6 7.3 0.0 3.1 2 1 1 3 3 3 0 C2 domain EF-hand_7 PF13499.6 EDP42973.1 - 0.093 13.2 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 EDP42973.1 - 0.17 11.7 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Mg_trans_NIPA PF05653.14 EDP42974.1 - 2e-20 73.1 11.7 5.4e-11 42.2 2.4 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA Ribosomal_L13 PF00572.18 EDP42976.1 - 1.1e-11 45.1 0.3 8.3e-10 39.0 0.0 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 BBP1_C PF15272.6 EDP42976.1 - 0.002 18.0 0.2 0.0027 17.6 0.2 1.2 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal Alpha-2-MRAP_C PF06401.11 EDP42976.1 - 0.044 13.7 0.9 0.054 13.4 0.1 1.5 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Ribosomal_L32e PF01655.18 EDP42977.1 - 5.1e-44 149.1 0.2 6e-44 148.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 SlyX PF04102.12 EDP42978.1 - 0.31 11.7 0.1 0.31 11.7 0.1 4.1 5 0 0 5 5 5 0 SlyX CRAL_TRIO PF00650.20 EDP42979.1 - 1.2e-18 67.4 0.0 1.8e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain SPA PF08616.10 EDP42980.1 - 7.6e-10 38.8 0.0 1.4e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EDP42980.1 - 8.5e-05 21.4 0.0 0.25 10.0 0.0 2.3 2 0 0 2 2 2 2 Transport protein Avl9 DENN PF02141.21 EDP42980.1 - 0.0016 18.4 0.0 0.011 15.7 0.0 2.2 1 1 0 1 1 1 1 DENN (AEX-3) domain Apt1 PF10351.9 EDP42980.1 - 0.46 9.3 5.0 0.74 8.6 5.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DEAD PF00270.29 EDP42981.1 - 3.5e-35 121.3 0.3 9.3e-35 120.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP42981.1 - 1.7e-29 102.4 0.1 3.7e-29 101.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EDP42981.1 - 0.026 14.2 0.0 0.068 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain TIMELESS PF04821.14 EDP42982.1 - 6.1e-75 252.0 0.0 9.5e-75 251.4 0.0 1.3 1 0 0 1 1 1 1 Timeless protein HEAT_2 PF13646.6 EDP42982.1 - 0.017 15.5 0.1 0.11 12.9 0.1 2.5 1 0 0 1 1 1 0 HEAT repeats DCP1 PF06058.13 EDP42983.1 - 3.9e-28 97.7 0.0 4.2e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Dcp1-like decapping family Di19_C PF14571.6 EDP42984.1 - 0.64 10.6 4.7 3.4 8.2 0.0 2.8 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal Yippee-Mis18 PF03226.14 EDP42985.1 - 1.9e-25 89.1 0.0 2.8e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Cyclin_N PF00134.23 EDP42986.1 - 2.1e-43 147.1 0.2 1.7e-41 140.9 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDP42986.1 - 7.3e-32 110.0 0.1 1.2e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain JAB PF01398.21 EDP42987.1 - 3.1e-31 107.8 0.7 1.1e-30 106.0 0.4 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EDP42987.1 - 0.00012 21.9 0.2 0.00034 20.3 0.1 1.9 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EDP42987.1 - 0.082 12.9 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) NUFIP2 PF15293.6 EDP42987.1 - 1.3 7.8 4.0 1.1 8.1 0.2 2.0 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 2 Aldedh PF00171.22 EDP42988.1 - 1.7e-59 201.6 0.0 2.7e-59 200.9 0.0 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Aminotran_1_2 PF00155.21 EDP42989.1 - 3.4e-43 148.2 0.0 2.1e-42 145.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 EDP42989.1 - 0.0065 15.3 0.0 0.011 14.5 0.0 1.3 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain WD40 PF00400.32 EDP42991.1 - 7.7e-17 61.4 2.2 0.00014 22.6 0.3 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP42991.1 - 2.7e-07 30.8 0.0 7.9e-06 26.1 0.0 3.1 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 EDP42991.1 - 0.0026 16.5 0.0 0.011 14.3 0.0 1.6 1 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ge1_WD40 PF16529.5 EDP42991.1 - 0.028 13.4 0.3 0.2 10.6 0.0 2.3 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 EDP42991.1 - 0.089 12.8 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat GTP_EFTU PF00009.27 EDP42992.1 - 1.6e-49 168.1 0.0 2.4e-49 167.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDP42992.1 - 4.8e-07 30.1 0.0 9.4e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.24 EDP42992.1 - 6.7e-07 29.3 0.0 1.3e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EDP42992.1 - 1.3e-05 25.2 0.0 3.5e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EDP42992.1 - 1.5e-05 25.1 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 EDP42992.1 - 1.7e-05 24.7 0.0 3.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 EDP42992.1 - 0.0045 16.6 0.0 0.0086 15.7 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDP42992.1 - 0.026 13.9 0.0 0.061 12.7 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MeaB PF03308.16 EDP42992.1 - 0.068 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PLA2_B PF01735.18 EDP42993.1 - 8.7e-146 486.2 0.6 1.1e-145 485.9 0.6 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DUF4516 PF14990.6 EDP42993.1 - 3.2 7.6 4.3 7.1 6.4 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4516) His_Phos_1 PF00300.22 EDP42994.1 - 2.3e-15 56.8 1.1 2.3e-10 40.5 0.0 3.6 2 2 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) DAGAT PF03982.13 EDP42995.1 - 6.7e-100 333.8 0.0 8e-100 333.6 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DUF3437 PF11919.8 EDP42995.1 - 0.048 13.6 0.0 0.23 11.4 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Cnd2 PF05786.14 EDP42996.1 - 1.5e-145 486.9 18.6 9.3e-142 474.3 18.6 3.7 1 1 0 1 1 1 1 Condensin complex subunit 2 CDP-OH_P_transf PF01066.21 EDP42997.1 - 4.5e-18 65.8 0.0 4.5e-18 65.8 0.0 3.1 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase CNH PF00780.22 EDP42998.1 - 3.5e-28 99.0 0.0 6.2e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EDP42998.1 - 3.6e-27 95.8 0.0 7.4e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EDP42998.1 - 0.00043 20.7 0.1 0.0019 18.7 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_5 PF15405.6 EDP42998.1 - 0.005 16.9 0.0 0.12 12.5 0.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain Sulfate_transp PF00916.20 EDP42999.1 - 1.3e-113 379.6 11.0 1.7e-113 379.2 11.0 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EDP42999.1 - 2.9e-09 36.6 0.0 1e-08 34.8 0.0 1.9 2 0 0 2 2 2 1 STAS domain MFS_MOT1 PF16983.5 EDP42999.1 - 0.0032 17.9 10.1 0.027 14.9 1.2 3.0 2 1 0 2 2 2 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 EDP42999.1 - 0.0039 17.5 0.1 0.01 16.1 0.1 1.6 1 0 0 1 1 1 1 STAS domain SNN_transmemb PF09049.10 EDP42999.1 - 0.019 14.9 0.4 0.019 14.9 0.4 2.4 2 0 0 2 2 2 0 Stannin transmembrane BRCT PF00533.26 EDP43000.1 - 1.8e-23 82.7 0.0 3.9e-09 36.8 0.0 4.9 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EDP43000.1 - 6e-23 80.6 2.4 9e-14 51.2 0.1 4.8 5 0 0 5 5 5 3 twin BRCT domain BRCT_2 PF16589.5 EDP43000.1 - 7.9e-15 55.0 0.0 0.00056 20.3 0.0 4.9 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EDP43000.1 - 1.1e-14 54.1 0.1 3.5e-14 52.5 0.1 1.9 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EDP43000.1 - 0.00019 21.6 1.2 0.44 10.9 0.0 3.6 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain PAT1 PF09770.9 EDP43001.1 - 7.8e-61 206.4 6.2 1e-59 202.7 6.2 2.4 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 PAT1 PF09770.9 EDP43002.1 - 2e-11 43.0 5.4 9.4e-11 40.7 5.4 1.8 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 EDP43002.1 - 0.54 10.2 4.4 0.72 9.8 4.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sec1 PF00995.23 EDP43003.1 - 2.1e-102 344.3 0.0 2.6e-102 343.9 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DASH_Hsk3 PF08227.11 EDP43004.1 - 4.5e-15 55.7 2.9 6.2e-15 55.3 2.9 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Aminotran_1_2 PF00155.21 EDP43005.1 - 2.5e-18 66.4 0.0 2.8e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EDP43005.1 - 6.3e-10 38.4 0.0 8.1e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase LSM PF01423.22 EDP43006.1 - 1e-18 66.7 1.2 4.3e-18 64.8 1.2 1.8 1 1 0 1 1 1 1 LSM domain ROF PF07073.12 EDP43006.1 - 0.18 12.0 0.1 0.53 10.5 0.0 1.7 1 1 0 2 2 2 0 Modulator of Rho-dependent transcription termination (ROF) IU_nuc_hydro PF01156.19 EDP43008.1 - 3.3e-38 132.0 0.0 5.5e-38 131.3 0.0 1.3 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CN_hydrolase PF00795.22 EDP43009.1 - 5e-28 98.2 0.1 8.3e-28 97.4 0.0 1.3 1 1 1 2 2 2 1 Carbon-nitrogen hydrolase DEAD PF00270.29 EDP43010.1 - 4.8e-46 156.7 0.0 1.8e-45 154.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43010.1 - 1.2e-29 102.9 0.0 2.4e-29 101.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43010.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit PDZ_5 PF17817.1 EDP43011.1 - 0.019 15.3 0.3 0.05 13.9 0.3 1.7 1 0 0 1 1 1 0 PDZ domain Ribosomal_L5_C PF00673.21 EDP43012.1 - 5.8e-22 77.7 0.0 1e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EDP43012.1 - 2.9e-17 62.7 0.0 7.1e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L5 MKT1_C PF12246.8 EDP43013.1 - 2.3e-73 246.4 0.0 5.4e-73 245.2 0.1 1.6 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EDP43013.1 - 1e-24 86.7 0.0 3.2e-24 85.1 0.0 1.9 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EDP43013.1 - 2.4e-07 31.2 0.0 5.9e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain Pkinase PF00069.25 EDP43014.1 - 1.5e-53 181.9 0.0 3e-53 180.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43014.1 - 3.2e-27 95.4 0.0 5.9e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43014.1 - 1.5e-05 24.5 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP43014.1 - 0.0004 20.4 0.0 0.00081 19.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP43014.1 - 0.004 16.0 0.0 0.0067 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EDP43014.1 - 0.0074 15.9 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EDP43014.1 - 0.0081 15.5 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDP43014.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Carn_acyltransf PF00755.20 EDP43015.1 - 8.1e-161 536.6 0.0 9.5e-161 536.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase UPF0047 PF01894.17 EDP43016.1 - 6.8e-37 126.1 0.0 7.7e-37 126.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Histidinol_dh PF00815.20 EDP43017.1 - 1.6e-162 541.2 1.4 2.5e-162 540.6 1.4 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EDP43017.1 - 2.1e-24 85.2 0.7 5.1e-24 83.9 0.3 1.9 2 0 0 2 2 2 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EDP43017.1 - 2e-12 47.3 0.0 1.3e-11 44.8 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 EDP43017.1 - 0.0053 16.9 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain Peptidase_S10 PF00450.22 EDP43018.1 - 1.2e-51 176.5 0.0 1.5e-51 176.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase YorP PF09629.10 EDP43018.1 - 0.14 12.4 0.0 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 YorP protein Maf1 PF09174.10 EDP43019.1 - 2.5e-36 125.4 0.0 5.4e-30 104.8 0.0 2.5 2 0 0 2 2 2 2 Maf1 regulator GTSE1_N PF15259.6 EDP43020.1 - 0.009 16.2 1.8 0.026 14.7 1.8 1.8 1 0 0 1 1 1 1 G-2 and S-phase expressed 1 Erythro-docking PF09277.11 EDP43020.1 - 0.06 13.3 2.1 0.18 11.7 2.1 1.9 1 0 0 1 1 1 0 Erythronolide synthase, docking Pex24p PF06398.11 EDP43021.1 - 0.036 13.1 11.9 0.06 12.3 11.9 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin EF-hand_1 PF00036.32 EDP43022.1 - 3.1e-24 82.7 3.0 1.1e-08 34.0 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EDP43022.1 - 1.8e-19 69.9 0.1 4e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EDP43022.1 - 3.2e-19 68.5 1.7 3.1e-14 52.5 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDP43022.1 - 3.2e-19 67.1 4.0 1e-07 31.3 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EDP43022.1 - 8.8e-19 66.1 2.5 7.3e-07 28.4 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EDP43022.1 - 1.9e-07 31.3 0.1 4.7e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 EDP43022.1 - 0.00098 19.2 0.0 0.0026 17.8 0.0 1.6 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.13 EDP43022.1 - 0.002 18.1 0.0 0.022 14.8 0.0 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.9 EDP43022.1 - 0.0053 17.1 0.0 1.1 9.6 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Poly_export PF02563.16 EDP43022.1 - 0.012 15.8 0.0 0.42 10.9 0.0 2.3 1 1 1 2 2 2 0 Polysaccharide biosynthesis/export protein EF-hand_4 PF12763.7 EDP43022.1 - 0.013 15.5 0.1 0.041 13.8 0.1 1.9 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EDP43022.1 - 0.034 14.3 0.7 1.3 9.2 0.3 2.5 1 1 1 2 2 2 0 Dockerin type I domain TerB PF05099.13 EDP43022.1 - 0.046 13.7 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TerB Sel1 PF08238.12 EDP43023.1 - 1.2e-45 152.9 14.4 3.5e-09 37.0 0.1 7.3 6 1 1 7 7 7 7 Sel1 repeat TPR_14 PF13428.6 EDP43023.1 - 0.058 14.2 4.0 1.5 9.9 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat GATA PF00320.27 EDP43024.1 - 0.00041 19.9 6.5 0.018 14.6 0.2 2.6 2 0 0 2 2 2 2 GATA zinc finger HA2 PF04408.23 EDP43025.1 - 1.7e-23 82.9 2.4 2.2e-23 82.6 0.1 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDP43025.1 - 2.5e-22 79.0 0.0 5.3e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDP43025.1 - 4.7e-13 49.4 0.0 1.4e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EDP43025.1 - 4.7e-09 36.5 0.1 1e-08 35.4 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 EDP43025.1 - 7.7e-05 22.5 0.1 0.00015 21.6 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDP43025.1 - 0.00047 20.4 0.1 0.0017 18.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP43025.1 - 0.00086 19.1 0.0 0.0026 17.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EDP43025.1 - 0.0039 17.7 1.2 0.13 12.7 0.1 2.9 2 1 1 3 3 3 1 ABC transporter T2SSE PF00437.20 EDP43025.1 - 0.0045 16.1 0.0 0.013 14.6 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EDP43025.1 - 0.0092 16.3 0.0 0.02 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Glyco_transf_8C PF08437.10 EDP43025.1 - 0.047 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 8 C-terminal ATPase PF06745.13 EDP43025.1 - 0.075 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 EDP43025.1 - 0.12 11.9 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 EDP43025.1 - 0.12 12.4 0.0 0.7 9.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EDP43025.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EDP43025.1 - 0.16 12.1 1.1 0.63 10.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain PWI PF01480.17 EDP43025.1 - 0.17 12.2 0.0 0.47 10.8 0.0 1.7 1 0 0 1 1 1 0 PWI domain DUF2075 PF09848.9 EDP43025.1 - 0.19 11.0 0.0 0.19 11.0 0.0 2.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) PAPA-1 PF04795.12 EDP43026.1 - 3e-27 95.3 4.6 3e-27 95.3 4.6 4.0 2 1 0 2 2 2 1 PAPA-1-like conserved region Polysacc_deac_2 PF04748.13 EDP43026.1 - 0.021 14.0 0.2 0.039 13.1 0.2 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase ThiF PF00899.21 EDP43027.1 - 2.2e-72 243.4 0.1 2.9e-72 242.9 0.1 1.0 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 EDP43027.1 - 2.3e-13 50.6 0.4 3.7e-09 36.9 0.1 2.3 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 EDP43027.1 - 0.0025 17.9 0.7 0.01 15.9 0.2 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EDP43027.1 - 0.0084 16.5 0.1 0.033 14.6 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding VEK-30 PF12107.8 EDP43027.1 - 0.13 12.3 0.9 0.29 11.1 0.9 1.6 1 0 0 1 1 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway MFS_1 PF07690.16 EDP43028.1 - 2.8e-20 72.6 40.3 2.2e-18 66.3 11.0 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP43028.1 - 9.8e-06 24.7 1.3 9.8e-06 24.7 1.3 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EDP43028.1 - 0.00097 18.1 0.5 0.00097 18.1 0.5 3.3 2 2 2 4 4 4 1 MFS_1 like family TFIIE_alpha PF02002.17 EDP43029.1 - 9.3e-13 47.9 0.0 1.9e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 EDP43029.1 - 0.056 13.0 1.3 0.13 11.8 1.3 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding HTH_Crp_2 PF13545.6 EDP43029.1 - 0.11 12.5 0.7 0.33 11.0 0.8 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain NMD3 PF04981.13 EDP43030.1 - 5.8e-79 265.0 6.6 7.9e-79 264.5 6.6 1.2 1 0 0 1 1 1 1 NMD3 family DZR PF12773.7 EDP43030.1 - 0.034 14.2 6.9 3.5 7.7 6.9 2.8 1 1 0 1 1 1 0 Double zinc ribbon DUF5321 PF17254.2 EDP43030.1 - 0.061 12.8 4.0 0.13 11.7 4.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5321) NinF PF05810.12 EDP43030.1 - 6.5 6.7 9.2 1.2 9.1 0.5 3.5 2 1 1 3 3 3 0 NinF protein rRNA_proc-arch PF13234.6 EDP43031.1 - 2.8e-78 263.6 0.0 4.6e-78 262.9 0.0 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EDP43031.1 - 4.2e-52 176.1 0.5 1.1e-51 174.8 0.5 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EDP43031.1 - 1.8e-18 66.9 0.0 2.9e-17 63.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43031.1 - 2.5e-06 27.8 0.0 9.8e-06 25.9 0.0 2.0 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43031.1 - 0.00063 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4868 PF16162.5 EDP43031.1 - 0.038 13.9 0.1 0.071 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4868) T2SSE PF00437.20 EDP43031.1 - 0.16 11.0 0.0 1.2 8.1 0.0 2.3 3 0 0 3 3 3 0 Type II/IV secretion system protein UMP1 PF05348.11 EDP43032.1 - 3e-29 101.6 0.2 3.9e-29 101.3 0.2 1.2 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 UCH PF00443.29 EDP43033.1 - 9.6e-37 126.9 0.0 1.2e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP43033.1 - 1.4e-06 28.1 0.0 1.7e-05 24.6 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDP43033.1 - 0.17 11.4 0.0 0.17 11.4 0.0 2.4 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase GCS PF03074.16 EDP43034.1 - 9.5e-154 512.2 0.0 1.2e-153 511.8 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase Vps16_N PF04841.13 EDP43035.1 - 1.7e-49 168.7 0.0 6.5e-32 110.8 0.0 2.1 2 0 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.12 EDP43035.1 - 5.9e-46 157.0 0.0 1.1e-27 96.9 0.0 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region Tubulin_3 PF14881.6 EDP43036.1 - 1.3e-17 64.0 0.0 2.2e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 EDP43036.1 - 0.1 12.8 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain DIM1 PF02966.16 EDP43037.1 - 9.9e-32 109.5 0.1 1.1e-31 109.4 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Pterin_4a PF01329.19 EDP43038.1 - 5.8e-26 90.5 0.0 7.2e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase ATP-synt_G PF04718.15 EDP43039.1 - 2.8e-17 63.4 0.3 5.5e-17 62.4 0.1 1.6 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Y_phosphatase2 PF03162.13 EDP43040.1 - 6.5e-59 198.2 0.0 9.3e-59 197.7 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EDP43040.1 - 1.2e-07 31.9 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EDP43040.1 - 0.00071 19.2 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDP43040.1 - 0.0026 17.6 0.0 0.0045 16.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain HORMA PF02301.18 EDP43041.1 - 9.5e-29 100.5 0.2 1.1e-28 100.3 0.2 1.0 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EDP43041.1 - 2e-05 24.6 0.3 3.6e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 Autophagy-related protein 101 bacHORMA_2 PF18173.1 EDP43041.1 - 0.00041 20.2 0.2 0.0017 18.2 0.1 2.0 2 1 0 2 2 2 1 Bacterial HORMA domain 2 DUF1682 PF07946.14 EDP43041.1 - 0.014 14.6 0.2 0.016 14.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MCM PF00493.23 EDP43042.1 - 1.9e-83 279.0 0.0 3e-83 278.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP43042.1 - 1.6e-24 86.1 0.5 5e-24 84.5 0.5 1.7 1 1 1 2 2 2 1 MCM OB domain MCM_N PF14551.6 EDP43042.1 - 3e-15 56.7 0.3 8.3e-15 55.3 0.2 1.8 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EDP43042.1 - 1.2e-07 31.8 0.0 3.9e-07 30.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDP43042.1 - 3.7e-07 29.8 0.0 0.00013 21.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDP43042.1 - 2.9e-05 23.9 0.0 0.0011 18.9 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDP43042.1 - 0.0009 19.0 0.0 0.95 9.2 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 EDP43042.1 - 0.024 15.0 0.0 0.2 12.0 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EDP43042.1 - 0.068 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MCM_lid PF17855.1 EDP43043.1 - 6.3e-09 36.1 0.9 6.3e-09 36.1 0.9 1.8 2 0 0 2 2 2 1 MCM AAA-lid domain DUF4778 PF16008.5 EDP43043.1 - 0.021 14.9 0.3 0.022 14.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) GGA_N-GAT PF18308.1 EDP43043.1 - 0.054 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 GGA N-GAT domain CPSF73-100_C PF11718.8 EDP43044.1 - 6.6e-54 182.7 0.0 1.2e-53 181.9 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EDP43044.1 - 2.8e-30 104.9 0.0 5.7e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EDP43044.1 - 4.3e-17 61.8 0.1 4.3e-17 61.8 0.1 2.2 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 EDP43044.1 - 4.9e-14 52.2 0.0 2.9e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EDP43044.1 - 0.0032 17.5 0.0 0.0072 16.4 0.0 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RabGAP-TBC PF00566.18 EDP43045.1 - 6.2e-47 160.0 0.0 9e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_L37 PF08561.10 EDP43046.1 - 0.00012 22.6 15.5 0.00016 22.2 15.5 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 DUF4158 PF13700.6 EDP43046.1 - 0.089 12.6 6.6 0.11 12.3 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) vATP-synt_E PF01991.18 EDP43047.1 - 9.1e-62 208.0 11.6 1.1e-61 207.8 11.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit SNARE PF05739.19 EDP43047.1 - 0.085 12.9 0.0 0.28 11.2 0.0 1.9 1 0 0 1 1 1 0 SNARE domain TTc_toxin_rep PF18807.1 EDP43047.1 - 0.13 12.2 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 Tripartite Tc toxins repeat UPF0449 PF15136.6 EDP43047.1 - 6.1 7.4 10.1 4.3 7.9 7.9 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 RRM_1 PF00076.22 EDP43048.1 - 4.4e-13 48.8 0.1 7e-13 48.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 EDP43048.1 - 6.4e-10 39.5 1.4 8.1e-10 39.2 0.5 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G Ribonucleas_3_3 PF14622.6 EDP43049.1 - 1.9e-36 125.1 0.0 2.8e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EDP43049.1 - 0.002 18.7 0.0 0.0048 17.5 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain Tim17 PF02466.19 EDP43050.1 - 0.054 13.9 3.0 0.11 12.9 1.0 2.5 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Mito_carr PF00153.27 EDP43051.1 - 1.4e-69 230.1 3.8 8.2e-24 83.4 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Ribosomal_S13 PF00416.22 EDP43052.1 - 3.4e-52 176.2 2.4 4e-52 176.0 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EDP43052.1 - 0.0015 17.4 0.0 0.0018 17.2 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 EDP43052.1 - 0.021 15.1 0.4 0.077 13.3 0.1 2.0 1 1 0 2 2 2 0 Helix-hairpin-helix motif DUF1822 PF08852.11 EDP43052.1 - 0.023 13.7 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) NAD_binding_5 PF07994.12 EDP43052.1 - 0.063 12.6 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase CPSase_L_D2 PF02786.17 EDP43053.1 - 3.3e-81 271.8 0.1 1.3e-80 269.8 0.0 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EDP43053.1 - 1.2e-66 224.2 0.0 1.9e-66 223.6 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EDP43053.1 - 3.5e-39 133.8 0.0 1.1e-38 132.2 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EDP43053.1 - 2.1e-29 101.8 0.0 5.6e-29 100.4 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EDP43053.1 - 1.9e-25 89.9 0.0 3.9e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EDP43053.1 - 8e-15 54.4 0.6 2e-14 53.2 0.6 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EDP43053.1 - 7.5e-11 41.7 0.7 7.4e-06 25.7 0.4 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EDP43053.1 - 1e-10 41.5 0.0 1.9e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDP43053.1 - 5.4e-06 26.1 0.1 1.3e-05 24.8 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain HlyD_3 PF13437.6 EDP43053.1 - 6.3e-05 23.6 0.0 0.27 12.0 0.0 2.9 2 0 0 2 2 2 2 HlyD family secretion protein ATP-grasp_3 PF02655.14 EDP43053.1 - 0.00021 21.4 0.0 0.00042 20.4 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EDP43053.1 - 0.00035 19.8 0.0 0.013 14.8 0.0 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion NQRA PF05896.11 EDP43053.1 - 0.0018 17.8 0.3 0.0031 17.0 0.3 1.3 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATP-grasp_4 PF13535.6 EDP43053.1 - 0.042 13.5 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain GCV_H PF01597.19 EDP43053.1 - 0.07 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein ATPgrasp_ST PF14397.6 EDP43053.1 - 0.14 11.4 0.0 0.32 10.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.6 EDP43053.1 - 0.17 11.7 0.3 0.54 10.0 0.1 2.0 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon Aminotran_3 PF00202.21 EDP43055.1 - 4.3e-117 391.2 0.0 5.1e-117 391.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EDP43055.1 - 0.011 14.9 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Methyltrn_RNA_3 PF02598.17 EDP43055.1 - 0.063 12.8 0.0 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methyltransferase Forkhead PF00250.18 EDP43056.1 - 2.7e-31 107.7 0.0 5e-31 106.8 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain Cullin PF00888.22 EDP43057.1 - 1.2e-200 668.3 0.0 1.6e-200 667.9 0.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDP43057.1 - 3e-26 91.2 0.3 7.9e-26 89.9 0.3 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain TFIIF_beta PF02270.15 EDP43057.1 - 0.18 12.0 0.5 0.61 10.3 0.0 2.1 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain Pkinase PF00069.25 EDP43058.1 - 7.7e-34 117.2 0.0 1e-22 80.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43058.1 - 1.3e-17 63.9 0.0 5.8e-12 45.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDP43058.1 - 0.0001 21.7 0.1 0.016 14.6 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 EDP43058.1 - 0.12 11.7 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP43058.1 - 2.3 8.1 7.8 0.15 11.9 0.6 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family GATA PF00320.27 EDP43059.1 - 2e-15 56.1 7.0 2e-15 56.1 7.0 2.9 3 0 0 3 3 3 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 EDP43059.1 - 0.0074 15.8 1.6 0.018 14.5 1.6 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EDP43059.1 - 0.031 14.4 0.3 0.1 12.7 0.3 1.9 1 0 0 1 1 1 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.15 EDP43059.1 - 0.26 11.4 3.9 1.3 9.1 1.7 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Fes1 PF08609.10 EDP43061.1 - 4.3e-24 85.2 0.5 5.3e-24 84.9 0.5 1.1 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 TPR_2 PF07719.17 EDP43062.1 - 5.9e-30 101.0 19.9 0.00038 20.3 0.1 10.0 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 EDP43062.1 - 1.4e-23 81.7 9.9 0.0082 15.9 0.0 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43062.1 - 5.5e-16 57.4 3.2 0.0058 16.8 0.0 8.1 10 0 0 10 10 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP43062.1 - 7.3e-15 55.0 14.6 6.4e-09 35.9 1.1 5.7 4 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EDP43062.1 - 1.7e-11 44.2 26.7 1.4e-05 25.3 1.1 8.2 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43062.1 - 5.5e-11 42.3 23.4 0.3 12.0 0.2 8.5 7 1 1 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43062.1 - 6e-10 39.6 36.3 0.00021 21.9 0.0 8.4 6 1 3 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43062.1 - 2.1e-08 34.6 19.6 0.12 12.9 0.4 7.9 7 1 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDP43062.1 - 1.1e-07 31.5 4.6 0.47 10.2 0.1 6.2 6 0 0 6 6 6 2 TPR repeat TPR_17 PF13431.6 EDP43062.1 - 2e-06 27.8 0.6 3.4 8.3 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP43062.1 - 4.1e-06 27.1 20.1 2.7 8.8 0.0 8.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDP43062.1 - 0.005 16.7 13.8 0.07 13.0 0.1 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 EDP43062.1 - 0.0059 16.6 4.1 11 6.1 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP43062.1 - 0.02 14.9 16.6 3.5 7.9 0.0 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDP43062.1 - 0.067 13.8 21.7 0.2 12.4 0.5 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat ANAPC8 PF04049.13 EDP43062.1 - 0.081 13.0 0.0 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 TPR_9 PF13371.6 EDP43062.1 - 0.13 12.4 13.9 1.6 8.9 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat PPR PF01535.20 EDP43062.1 - 0.18 12.2 0.0 13 6.3 0.0 3.9 4 0 0 4 4 3 0 PPR repeat HhH-GPD PF00730.25 EDP43063.1 - 1.5e-17 64.0 0.0 3e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 EDP43063.1 - 3.7e-16 59.1 0.6 5.4e-08 32.8 0.2 2.6 1 1 1 2 2 2 2 NUDIX domain HHH PF00633.23 EDP43063.1 - 0.00018 21.2 0.3 0.0007 19.3 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EDP43063.1 - 0.028 14.7 8.5 0.068 13.5 8.5 1.7 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III HHH_5 PF14520.6 EDP43063.1 - 0.031 14.9 0.0 12 6.6 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain MF_alpha_N PF05436.11 EDP43064.1 - 0.12 12.3 0.2 0.17 11.8 0.2 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Clat_adaptor_s PF01217.20 EDP43065.1 - 3.8e-45 153.3 0.4 3.7e-33 114.4 0.1 2.1 2 0 0 2 2 2 2 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.6 EDP43065.1 - 0.043 13.8 0.2 0.063 13.3 0.2 1.2 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Arf PF00025.21 EDP43066.1 - 1.7e-42 144.8 0.0 1.9e-42 144.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP43066.1 - 0.00012 22.3 0.0 0.00018 21.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EDP43066.1 - 0.0012 18.1 0.1 0.0016 17.7 0.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Ras PF00071.22 EDP43066.1 - 0.0018 17.9 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EDP43066.1 - 0.0059 16.1 0.0 0.0068 15.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Acyl-CoA_dh_1 PF00441.24 EDP43067.1 - 2.5e-29 102.4 0.8 3.7e-29 101.9 0.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDP43067.1 - 4e-15 56.5 0.0 1.2e-14 55.0 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EDP43067.1 - 5.6e-15 55.3 0.1 1.1e-14 54.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDP43067.1 - 5.1e-06 26.8 0.1 9.4e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DAO PF01266.24 EDP43068.1 - 5e-43 148.0 0.0 6e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP43068.1 - 9.3e-08 31.6 0.0 0.0006 19.1 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDP43068.1 - 1.5e-07 30.9 0.2 5.4e-07 29.0 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDP43068.1 - 1.5e-06 28.4 0.1 7.6e-06 26.1 0.1 2.3 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDP43068.1 - 2.4e-06 28.0 0.0 6.9e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDP43068.1 - 9.8e-06 25.0 0.2 2.5e-05 23.7 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EDP43068.1 - 3.2e-05 23.2 0.0 0.032 13.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A 3HCDH_N PF02737.18 EDP43068.1 - 0.00017 21.5 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EDP43068.1 - 0.00017 21.6 0.1 0.24 11.4 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding TrkA_N PF02254.18 EDP43068.1 - 0.0019 18.4 0.0 0.0037 17.5 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_3 PF13738.6 EDP43068.1 - 0.0022 17.3 0.0 0.025 13.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EDP43068.1 - 0.0022 17.7 0.1 0.0051 16.5 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EDP43068.1 - 0.0048 16.2 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EDP43068.1 - 0.0058 16.2 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EDP43068.1 - 0.0095 16.2 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 EDP43068.1 - 0.016 14.6 0.2 0.34 10.2 0.2 2.1 2 0 0 2 2 2 0 ThiF family NAD_binding_7 PF13241.6 EDP43068.1 - 0.032 14.7 0.0 0.065 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 EDP43068.1 - 0.056 12.8 0.1 0.088 12.1 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDP43068.1 - 0.099 11.7 0.0 0.61 9.1 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.14 EDP43068.1 - 0.15 10.7 0.6 1.4 7.5 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Epimerase PF01370.21 EDP43068.1 - 0.16 11.4 0.2 1 8.8 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family UBN_AB PF14075.6 EDP43069.1 - 5.3e-30 104.8 0.1 5.3e-30 104.8 0.1 1.8 2 0 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.10 EDP43069.1 - 5.7e-11 42.2 0.1 5.7e-11 42.2 0.1 2.1 2 0 0 2 2 2 1 HPC2 and ubinuclein domain HSP70 PF00012.20 EDP43070.1 - 2.4e-260 864.9 13.5 2.8e-260 864.7 13.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDP43070.1 - 3.1e-19 69.0 0.6 7.6e-17 61.1 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.18 EDP43070.1 - 0.00021 20.6 2.5 0.051 12.8 0.2 3.0 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase FtsA PF14450.6 EDP43070.1 - 0.014 15.8 5.9 3.4 8.1 0.0 3.8 3 2 0 3 3 3 0 Cell division protein FtsA FGGY_C PF02782.16 EDP43070.1 - 0.063 13.0 0.0 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain DMRL_synthase PF00885.19 EDP43070.1 - 0.11 12.4 0.1 0.78 9.6 0.0 2.2 2 0 0 2 2 2 0 6,7-dimethyl-8-ribityllumazine synthase PI3K_P85_iSH2 PF16454.5 EDP43070.1 - 3.3 7.3 13.3 0.26 10.9 5.2 2.3 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CP12 PF02672.15 EDP43070.1 - 6.5 7.6 8.2 1.2 10.0 2.4 2.5 2 0 0 2 2 2 0 CP12 domain Spectrin PF00435.21 EDP43070.1 - 7 7.2 10.7 0.46 11.0 2.4 2.8 2 2 1 3 3 3 0 Spectrin repeat Pex2_Pex12 PF04757.14 EDP43071.1 - 4e-28 98.6 0.6 5.6e-28 98.1 0.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 EDP43071.1 - 2.1e-10 40.7 8.2 3.6e-10 40.0 8.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP43071.1 - 5.2e-10 39.0 7.2 9.4e-10 38.2 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP43071.1 - 1.8e-09 37.3 4.9 2.9e-09 36.6 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP43071.1 - 1.8e-08 34.1 6.4 2.9e-08 33.4 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDP43071.1 - 2.4e-08 34.1 5.5 4.6e-08 33.2 5.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EDP43071.1 - 4.9e-08 32.8 5.5 7.9e-08 32.1 5.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDP43071.1 - 2.1e-06 27.5 5.3 4.3e-06 26.5 5.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDP43071.1 - 7.3e-05 22.7 5.5 0.00022 21.2 5.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EDP43071.1 - 0.00088 19.4 4.0 0.00088 19.4 4.0 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EDP43071.1 - 0.0039 17.2 2.1 0.0074 16.3 2.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EDP43071.1 - 0.0046 16.8 2.0 0.009 15.9 2.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EDP43071.1 - 0.01 15.6 7.6 0.019 14.7 7.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain APP_amyloid PF10515.9 EDP43071.1 - 0.019 15.4 0.0 0.08 13.5 0.0 2.1 1 0 0 1 1 1 0 Beta-amyloid precursor protein C-terminus IBR PF01485.21 EDP43071.1 - 0.023 14.9 3.9 0.044 14.0 3.9 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_11 PF17123.5 EDP43071.1 - 0.085 12.6 1.5 0.21 11.4 1.5 1.7 1 0 0 1 1 1 0 RING-like zinc finger Baculo_IE-1 PF05290.11 EDP43071.1 - 0.15 12.0 0.3 0.26 11.2 0.3 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Zn_ribbon_17 PF17120.5 EDP43071.1 - 0.16 11.6 4.3 0.32 10.7 4.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.5 EDP43071.1 - 0.16 12.1 4.1 0.3 11.3 4.1 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF1272 PF06906.11 EDP43071.1 - 0.93 9.6 3.9 1.8 8.7 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Ras PF00071.22 EDP43073.1 - 2.2e-59 199.7 0.0 2.7e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP43073.1 - 1e-19 70.9 0.0 1.6e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP43073.1 - 4.3e-08 32.8 0.0 5e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDP43073.1 - 2.5e-05 24.2 0.3 0.041 13.8 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDP43073.1 - 4.4e-05 23.1 0.0 9.5e-05 22.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EDP43073.1 - 0.0011 19.0 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EDP43073.1 - 0.0037 16.8 0.0 0.011 15.3 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EDP43073.1 - 0.014 15.5 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EDP43073.1 - 0.019 14.8 1.9 0.24 11.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein GDA1_CD39 PF01150.17 EDP43074.1 - 6.9e-94 314.9 0.0 1.2e-93 314.1 0.0 1.3 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EDP43074.1 - 0.034 13.6 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Sec6 PF06046.13 EDP43075.1 - 2.9e-118 395.8 0.2 3.4e-117 392.2 0.0 2.0 2 0 0 2 2 2 1 Exocyst complex component Sec6 HTH_31 PF13560.6 EDP43075.1 - 0.025 14.9 2.0 0.06 13.7 0.1 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain DUF3510 PF12022.8 EDP43075.1 - 0.031 14.6 0.1 0.18 12.2 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) DFRP_C PF16543.5 EDP43076.1 - 6e-30 103.6 0.8 6e-30 103.6 0.8 3.5 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf_CCCH_4 PF18345.1 EDP43076.1 - 2.4e-05 24.2 6.1 2.4e-05 24.2 6.1 3.4 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH PF00642.24 EDP43076.1 - 0.00031 20.6 1.5 0.00031 20.6 1.5 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EDP43076.1 - 0.0012 18.6 11.6 0.013 15.3 2.7 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger Torus PF16131.5 EDP43076.1 - 0.012 16.3 17.1 0.014 16.1 6.0 3.5 2 1 1 3 3 3 0 Torus domain zf-CCCH_2 PF14608.6 EDP43076.1 - 0.018 15.5 10.6 0.41 11.2 3.0 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EDP43076.1 - 0.21 11.8 10.6 0.063 13.5 1.0 3.1 2 1 0 3 3 3 0 Zinc-finger containing family KI67R PF08065.12 EDP43076.1 - 6.8 7.3 19.0 4.3 7.9 0.2 3.3 3 0 0 3 3 3 0 KI67R (NUC007) repeat LRR_6 PF13516.6 EDP43078.1 - 7.5e-05 22.5 0.0 0.093 12.8 0.0 3.5 4 0 0 4 4 4 2 Leucine Rich repeat PseudoU_synth_1 PF01416.20 EDP43078.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 tRNA pseudouridine synthase AIRC PF00731.20 EDP43079.1 - 7.9e-64 213.7 0.7 1.7e-63 212.6 0.7 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EDP43079.1 - 3e-53 179.9 0.0 4.5e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EDP43079.1 - 2.7e-19 68.6 0.0 5.3e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 EDP43079.1 - 6.3e-05 22.6 0.0 0.00021 20.9 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EDP43079.1 - 0.017 15.2 0.0 0.067 13.2 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain PrpR_N PF06506.11 EDP43079.1 - 0.023 14.3 0.0 0.081 12.5 0.0 1.9 1 0 0 1 1 1 0 Propionate catabolism activator GMC_oxred_C PF05199.13 EDP43080.1 - 4e-35 121.5 0.2 7.1e-35 120.6 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EDP43080.1 - 6.4e-34 117.7 0.0 9.9e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase DUF3292 PF11696.8 EDP43081.1 - 8.6e-15 54.2 8.1 1e-06 27.5 1.4 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF3292) Reticulon PF02453.17 EDP43081.1 - 6e-05 23.1 1.1 0.014 15.3 0.2 2.3 2 0 0 2 2 2 2 Reticulon PRT_C PF08372.10 EDP43081.1 - 0.00055 19.7 4.7 0.00089 19.0 1.1 2.3 1 1 1 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 EDP43081.1 - 0.32 10.4 1.5 0.84 9.0 0.2 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) Arf PF00025.21 EDP43082.1 - 1.1e-79 265.9 0.1 1.3e-79 265.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP43082.1 - 2.7e-14 53.4 0.0 3.6e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDP43082.1 - 8e-14 51.5 0.0 9.9e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EDP43082.1 - 4.9e-13 49.0 0.9 4.3e-09 36.0 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EDP43082.1 - 1e-12 48.0 0.0 1.1e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDP43082.1 - 1.1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDP43082.1 - 3.9e-06 26.9 0.0 6.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EDP43082.1 - 0.0059 15.9 0.3 0.022 14.0 0.1 1.8 2 0 0 2 2 2 1 6-phosphofructo-2-kinase RNA_pol_I_A49 PF06870.12 EDP43083.1 - 2.2e-74 250.7 0.0 2.6e-74 250.4 0.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor GntR PF00392.21 EDP43083.1 - 0.096 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Plasmid_RAQPRD PF09686.10 EDP43083.1 - 0.098 12.9 0.4 2.9 8.2 0.1 2.6 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Methyltransf_28 PF02636.17 EDP43084.1 - 1.3e-67 228.3 0.0 1.6e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase eIF3_N PF09440.10 EDP43085.1 - 7.1e-41 139.8 3.4 1.5e-40 138.7 2.1 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EDP43085.1 - 1.8e-10 41.3 0.0 4.2e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 PCI domain Ribosomal_L36e PF01158.18 EDP43086.1 - 2.5e-37 127.0 4.1 2.8e-37 126.8 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Voldacs PF03517.13 EDP43087.1 - 9.2e-16 58.2 0.0 1.2e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Calcipressin PF04847.12 EDP43088.1 - 7e-25 87.9 0.2 1.8e-24 86.5 0.2 1.7 1 1 0 1 1 1 1 Calcipressin Ysc84 PF04366.12 EDP43089.1 - 2.5e-39 133.9 0.7 5.1e-39 132.9 0.7 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator PGAP1 PF07819.13 EDP43090.1 - 1.9e-61 207.7 0.0 2.8e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EDP43090.1 - 1.7e-05 25.5 1.8 2.4e-05 25.1 1.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EDP43090.1 - 0.00013 21.6 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EDP43090.1 - 0.0016 17.8 0.0 0.0021 17.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP43090.1 - 0.0031 17.2 1.4 0.046 13.3 0.1 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EDP43090.1 - 0.042 13.7 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 EDP43090.1 - 0.042 13.7 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF2048 PF09752.9 EDP43090.1 - 0.13 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Lipase_2 PF01674.18 EDP43090.1 - 0.16 11.5 0.1 1.2 8.6 0.0 2.2 3 0 0 3 3 3 0 Lipase (class 2) Nop14 PF04147.12 EDP43092.1 - 0.12 10.5 37.8 0.13 10.5 37.8 1.0 1 0 0 1 1 1 0 Nop14-like family DUF2722 PF10846.8 EDP43092.1 - 1.5 7.7 21.6 2 7.2 21.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Mpp10 PF04006.12 EDP43092.1 - 5.1 5.4 33.9 6.8 5.0 33.9 1.2 1 0 0 1 1 1 0 Mpp10 protein Tam41_Mmp37 PF09139.11 EDP43093.1 - 1.2e-107 360.1 0.0 1.5e-107 359.8 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Mur_ligase_M PF08245.12 EDP43094.1 - 0.00014 22.0 0.0 0.6 10.1 0.0 2.6 2 1 1 3 3 3 2 Mur ligase middle domain Mur_ligase_C PF02875.21 EDP43094.1 - 0.046 14.0 0.0 0.63 10.3 0.0 2.7 3 0 0 3 3 3 0 Mur ligase family, glutamate ligase domain Ribosomal_L6e PF01159.19 EDP43095.1 - 3.3e-38 130.7 0.1 4.9e-38 130.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 EDP43095.1 - 0.034 14.4 0.2 0.034 14.4 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein L6, N-terminal domain Pet127 PF08634.10 EDP43096.1 - 1.3e-104 349.5 0.0 1.9e-104 349.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 AC_N PF16214.5 EDP43096.1 - 1.4 7.9 3.2 2.4 7.2 3.2 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DER1 PF04511.15 EDP43097.1 - 3e-24 86.0 2.0 3.2e-24 85.9 2.0 1.0 1 0 0 1 1 1 1 Der1-like family F-actin_cap_A PF01267.17 EDP43098.1 - 9.4e-85 284.3 1.9 1.1e-84 284.0 1.9 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit F_actin_cap_B PF01115.17 EDP43098.1 - 6.9e-05 22.6 0.8 9.7e-05 22.1 0.1 1.5 2 0 0 2 2 2 1 F-actin capping protein, beta subunit Xpo1 PF08389.12 EDP43099.1 - 1e-09 38.6 0.1 6e-09 36.1 0.0 2.5 2 0 0 2 2 2 1 Exportin 1-like protein RIX1 PF08167.12 EDP43099.1 - 0.011 15.5 5.8 0.042 13.6 0.0 4.0 5 0 0 5 5 5 0 rRNA processing/ribosome biogenesis Ferrochelatase PF00762.19 EDP43100.1 - 5e-104 347.8 0.0 5.7e-104 347.6 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 EDP43100.1 - 0.012 16.0 0.0 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 CbiX ORF_12_N PF18042.1 EDP43100.1 - 0.096 13.1 0.4 8.9 6.8 0.2 2.8 2 0 0 2 2 2 0 ORF 12 gene product N-terminal Tcf25 PF04910.14 EDP43101.1 - 9.8e-95 317.6 0.0 1.2e-94 317.3 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 SCO1-SenC PF02630.14 EDP43102.1 - 1.7e-45 154.2 0.0 2.4e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EDP43102.1 - 0.0064 16.4 0.0 0.04 13.9 0.0 2.1 1 1 0 1 1 1 1 AhpC/TSA family HSF_DNA-bind PF00447.17 EDP43103.1 - 6.4e-22 78.0 0.0 9.2e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding PRP1_N PF06424.12 EDP43104.1 - 1.7e-49 168.1 5.0 1.7e-49 168.1 5.0 2.4 2 1 1 3 3 3 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EDP43104.1 - 1.4e-22 78.5 50.0 0.0013 19.4 0.9 15.1 5 3 11 16 16 15 10 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43104.1 - 1.1e-20 73.9 16.3 0.00074 20.0 1.0 9.5 8 2 2 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43104.1 - 1.6e-06 28.6 35.2 5.7e-06 26.9 2.9 8.5 8 2 1 9 9 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43104.1 - 4.4e-06 26.5 0.3 1.8 8.9 0.1 6.4 8 0 0 8 8 8 1 Tetratricopeptide repeat NARP1 PF12569.8 EDP43104.1 - 1.4e-05 24.3 0.7 0.36 9.7 0.0 4.8 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EDP43104.1 - 2.2e-05 24.2 5.5 3.9 7.8 0.1 7.2 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDP43104.1 - 0.00012 22.2 0.2 0.63 10.6 0.1 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP43104.1 - 0.02 15.1 0.4 14 6.0 0.1 4.7 4 1 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 EDP43104.1 - 0.026 14.0 2.0 0.27 10.6 0.1 3.3 3 1 1 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EDP43104.1 - 0.027 15.1 9.1 44 5.0 0.1 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat Suf PF05843.14 EDP43104.1 - 0.11 12.4 1.8 31 4.4 1.9 3.9 5 0 0 5 5 5 0 Suppressor of forked protein (Suf) TPR_12 PF13424.6 EDP43104.1 - 0.23 11.7 27.3 0.14 12.5 0.5 6.3 8 0 0 8 8 6 0 Tetratricopeptide repeat DEAD PF00270.29 EDP43105.1 - 1.1e-22 80.6 0.0 1.8e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EDP43105.1 - 5.1e-19 68.8 0.9 1.2e-18 67.6 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EDP43105.1 - 5.3e-11 42.8 0.0 2.5e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CDT1 PF08839.11 EDP43105.1 - 0.0019 18.5 0.1 0.0032 17.8 0.1 1.3 1 0 0 1 1 1 1 DNA replication factor CDT1 like Malic_M PF03949.15 EDP43106.1 - 5e-84 281.6 0.0 6.4e-84 281.2 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EDP43106.1 - 1.4e-60 204.2 0.0 2.1e-60 203.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Shikimate_DH PF01488.20 EDP43106.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_C PF02866.18 EDP43107.1 - 1.1e-46 158.8 0.0 2.5e-46 157.7 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EDP43107.1 - 4.1e-45 153.3 0.0 6.2e-45 152.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EDP43107.1 - 5.3e-05 22.4 0.0 7.9e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EDP43107.1 - 0.0063 17.0 0.1 0.034 14.6 0.0 2.2 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EDP43107.1 - 0.0087 15.4 0.3 0.12 11.6 0.0 2.6 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 EDP43107.1 - 0.17 11.4 0.1 0.58 9.7 0.1 1.8 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase Peptidase_C48 PF02902.19 EDP43108.1 - 1.5e-08 34.8 0.0 1.9e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C48 PF02902.19 EDP43109.1 - 1.1e-11 44.9 0.7 1.8e-11 44.3 0.7 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain HD_3 PF13023.6 EDP43110.1 - 7e-36 123.6 2.9 7e-36 123.6 2.9 2.0 2 0 0 2 2 2 1 HD domain HD_2 PF12917.7 EDP43110.1 - 3.7e-09 36.6 1.2 3.7e-09 36.6 1.2 1.8 2 0 0 2 2 2 1 HD containing hydrolase-like enzyme HD PF01966.22 EDP43110.1 - 0.1 12.8 6.7 0.035 14.3 2.8 2.2 2 0 0 2 2 2 0 HD domain Sulfate_transp PF00916.20 EDP43111.1 - 3.9e-25 88.4 17.9 7.2e-25 87.5 17.9 1.4 1 1 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 EDP43111.1 - 4.8e-05 23.7 12.5 0.01 16.2 1.8 3.4 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily Ras PF00071.22 EDP43112.1 - 8.1e-33 113.3 0.0 1.4e-20 73.5 0.0 2.2 2 0 0 2 2 2 2 Ras family EF_assoc_2 PF08356.12 EDP43112.1 - 3.6e-30 103.8 0.0 8e-30 102.7 0.0 1.6 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EDP43112.1 - 5.9e-28 96.3 0.1 5.9e-28 96.3 0.1 1.9 2 0 0 2 2 1 1 EF hand associated Roc PF08477.13 EDP43112.1 - 2e-17 63.5 0.0 1.7e-10 41.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_6 PF13405.6 EDP43112.1 - 1.3e-09 37.2 0.5 6.4e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EDP43112.1 - 6.4e-08 31.6 1.1 0.0023 17.3 0.0 2.6 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 EDP43112.1 - 1.1e-07 31.9 0.0 0.0066 16.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Arf PF00025.21 EDP43112.1 - 2.6e-07 30.3 0.0 0.016 14.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family EF-hand_7 PF13499.6 EDP43112.1 - 4.1e-07 30.3 0.1 0.0036 17.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EDP43112.1 - 9.9e-06 24.8 2.9 0.0035 16.8 0.0 2.8 2 1 0 2 2 2 2 EF hand AAA_18 PF13238.6 EDP43112.1 - 1.3e-05 25.7 0.0 0.028 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDP43112.1 - 2.6e-05 24.2 2.0 0.085 12.8 0.0 3.9 3 1 1 4 4 4 1 RsgA GTPase SRPRB PF09439.10 EDP43112.1 - 3e-05 23.5 0.0 0.096 12.1 0.0 2.5 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EDP43112.1 - 8e-05 23.1 0.0 0.13 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDP43112.1 - 0.00014 22.1 0.1 0.29 11.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain EF-hand_8 PF13833.6 EDP43112.1 - 0.00052 19.8 0.7 1.3 9.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.6 EDP43112.1 - 0.00059 19.7 2.7 0.093 12.6 0.5 2.4 2 0 0 2 2 2 1 EF hand AAA_29 PF13555.6 EDP43112.1 - 0.0012 18.6 0.1 1.6 8.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 EDP43112.1 - 0.0012 18.9 1.5 1.4 8.9 0.0 3.0 2 1 1 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 EDP43112.1 - 0.0013 18.3 0.2 0.061 12.8 0.0 2.5 2 1 0 3 3 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 EDP43112.1 - 0.0017 18.3 0.0 0.86 9.5 0.0 2.4 2 0 0 2 2 2 1 NACHT domain ABC_tran PF00005.27 EDP43112.1 - 0.0027 18.2 0.0 3 8.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_25 PF13481.6 EDP43112.1 - 0.0036 16.9 0.0 0.55 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDP43112.1 - 0.0058 16.8 0.1 0.57 10.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EDP43112.1 - 0.0076 15.4 0.2 2.1 7.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) cobW PF02492.19 EDP43112.1 - 0.0098 15.5 0.3 10 5.7 0.0 3.5 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain SPARC_Ca_bdg PF10591.9 EDP43112.1 - 0.015 15.6 0.5 6 7.2 0.0 3.2 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_28 PF13521.6 EDP43112.1 - 0.019 15.2 0.0 5.8 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EDP43112.1 - 0.026 14.3 0.4 7.3 6.3 0.0 3.7 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EDP43112.1 - 0.028 13.7 0.0 1.3 8.3 0.0 2.6 3 0 0 3 3 3 0 Septin AAA_7 PF12775.7 EDP43112.1 - 0.056 12.9 0.0 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EDP43112.1 - 0.067 12.9 0.0 7.7 6.2 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DAP3 PF10236.9 EDP43112.1 - 0.13 11.4 0.3 2.4 7.3 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 FtsK_SpoIIIE PF01580.18 EDP43112.1 - 0.14 11.5 0.6 0.9 8.8 0.0 2.4 3 0 0 3 3 3 0 FtsK/SpoIIIE family TsaE PF02367.17 EDP43112.1 - 0.15 12.1 0.0 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rnk_N PF14760.6 EDP43112.1 - 0.16 12.5 0.8 0.48 10.9 0.0 2.2 2 0 0 2 2 2 0 Rnk N-terminus ATPase_2 PF01637.18 EDP43112.1 - 0.16 11.8 0.0 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea VirE PF05272.11 EDP43112.1 - 0.21 11.3 0.0 18 5.0 0.0 2.8 3 0 0 3 3 3 0 Virulence-associated protein E AAA_5 PF07728.14 EDP43112.1 - 0.23 11.4 0.5 10 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) HECT PF00632.25 EDP43114.1 - 3.8e-86 289.3 0.0 5.4e-86 288.8 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HA2 PF04408.23 EDP43115.1 - 2.1e-15 56.9 0.1 4.3e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDP43115.1 - 8.7e-11 42.2 0.0 3.6e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDP43115.1 - 5.2e-09 36.3 0.0 1.6e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDP43115.1 - 0.0042 16.9 0.1 0.023 14.5 0.0 2.2 2 1 1 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EDP43115.1 - 0.11 12.5 0.0 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF5051 PF16473.5 EDP43115.1 - 0.19 11.7 0.5 0.46 10.5 0.5 1.6 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like DUF2373 PF10180.9 EDP43116.1 - 3.9e-10 39.4 1.5 2.2e-08 33.8 1.9 2.4 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) CDC45 PF02724.14 EDP43116.1 - 0.032 12.6 1.7 0.031 12.6 1.7 1.1 1 0 0 1 1 1 0 CDC45-like protein HGTP_anticodon2 PF12745.7 EDP43116.1 - 2.4 7.6 9.1 0.59 9.6 5.9 1.5 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs RRM_1 PF00076.22 EDP43117.1 - 4e-34 116.3 0.0 2.7e-12 46.3 0.0 5.3 6 0 0 6 6 6 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP43117.1 - 1.8e-07 31.0 0.0 0.023 14.7 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EDP43117.1 - 0.00066 19.7 0.0 1.7 8.8 0.0 4.3 5 0 0 5 5 5 1 RNA recognition motif RRM_occluded PF16842.5 EDP43117.1 - 0.0093 15.8 0.0 1.8 8.5 0.0 3.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM PF05172.13 EDP43117.1 - 0.029 14.3 0.0 0.58 10.1 0.0 2.6 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif VWA PF00092.28 EDP43118.1 - 0.00063 20.0 0.0 0.0037 17.5 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF3772 PF12607.8 EDP43118.1 - 0.024 14.4 1.0 0.05 13.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3772) Cullin PF00888.22 EDP43119.1 - 9.8e-167 556.3 8.8 1.3e-166 555.8 8.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDP43119.1 - 1e-26 92.8 1.5 2.9e-26 91.3 1.5 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HTH_IclR PF09339.10 EDP43119.1 - 0.0019 18.0 0.5 0.0078 16.0 0.5 2.2 1 0 0 1 1 1 1 IclR helix-turn-helix domain DprA_WH PF17782.1 EDP43119.1 - 0.18 12.0 0.1 0.48 10.6 0.1 1.7 1 0 0 1 1 1 0 DprA winged helix domain Pho88 PF10032.9 EDP43121.1 - 5.7e-12 45.3 0.0 6.4e-12 45.1 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Pho88 PF10032.9 EDP43122.1 - 1.5e-24 86.2 0.3 1.7e-24 86.1 0.3 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) WD40 PF00400.32 EDP43123.1 - 2e-07 31.6 16.0 0.00049 20.8 0.8 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43123.1 - 6.4e-06 26.4 0.0 0.019 15.3 0.0 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 EDP43123.1 - 0.1 11.3 0.8 5.2 5.7 0.7 2.7 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Sas10 PF09368.10 EDP43124.1 - 3.4e-25 88.3 4.0 3.4e-25 88.3 4.0 3.2 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EDP43124.1 - 8.7e-05 23.1 0.4 0.00039 21.0 0.4 2.1 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Fcf2 PF08698.11 EDP43125.1 - 3.5e-18 65.8 0.0 3.1e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 Fcf2 pre-rRNA processing EPL1 PF10513.9 EDP43126.1 - 5.6e-05 23.6 0.4 5.6e-05 23.6 0.4 3.1 3 0 0 3 3 3 1 Enhancer of polycomb-like Tom22 PF04281.13 EDP43127.1 - 5.4e-38 129.9 0.4 6.1e-38 129.7 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Importin_rep_4 PF18808.1 EDP43127.1 - 2.7 8.3 6.6 4.2 7.7 6.6 1.3 1 0 0 1 1 1 0 Importin repeat RRN3 PF05327.11 EDP43127.1 - 3.1 6.2 7.3 3.6 6.0 7.3 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EDP43127.1 - 3.1 5.8 6.5 3.6 5.6 6.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Calpain_inhib PF00748.19 EDP43128.1 - 3.9 8.0 7.9 0.42 11.1 1.8 2.2 2 0 0 2 2 2 0 Calpain inhibitor Na_H_Exchanger PF00999.21 EDP43129.1 - 1.5e-19 70.1 5.8 1.8e-19 69.8 5.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Insulin_TMD PF17870.1 EDP43129.1 - 0.14 12.2 1.0 0.37 10.9 1.0 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment dCMP_cyt_deam_1 PF00383.23 EDP43130.1 - 6e-10 38.9 0.0 9.5e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDP43130.1 - 1.4e-06 28.1 0.1 4.4e-06 26.5 0.1 1.8 1 1 0 1 1 1 1 MafB19-like deaminase SET PF00856.28 EDP43130.1 - 5.7e-05 23.6 0.0 0.00012 22.5 0.0 1.5 1 0 0 1 1 1 1 SET domain RXT2_N PF08595.11 EDP43131.1 - 0.41 10.7 5.0 1 9.4 5.0 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF3295 PF11702.8 EDP43131.1 - 0.51 9.6 12.4 0.046 13.1 8.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) NOA36 PF06524.12 EDP43131.1 - 5.9 6.1 18.3 8.4 5.6 18.3 1.2 1 0 0 1 1 1 0 NOA36 protein NUP214 PF16755.5 EDP43132.1 - 5e-13 49.0 0.0 8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 bMG5 PF17972.1 EDP43132.1 - 0.015 15.7 14.0 8.2 6.8 0.2 4.9 2 1 3 5 5 5 0 Bacterial Alpha-2-macroglobulin MG5 domain CK_II_beta PF01214.18 EDP43133.1 - 7e-52 175.9 0.0 8.2e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit PHD PF00628.29 EDP43134.1 - 1.2e-05 25.1 12.1 2.5e-05 24.1 12.1 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EDP43134.1 - 0.0042 17.0 2.7 0.012 15.5 2.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 FUSC PF04632.12 EDP43134.1 - 2.3 6.7 7.8 3.4 6.1 7.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-RING_9 PF13901.6 EDP43134.1 - 2.8 7.9 9.0 0.85 9.6 5.7 1.8 2 1 0 2 2 2 0 Putative zinc-RING and/or ribbon Pkinase PF00069.25 EDP43135.1 - 2.9e-65 220.3 0.0 4.8e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43135.1 - 1.7e-29 102.9 0.0 2.9e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP43135.1 - 0.0019 17.2 0.1 0.0074 15.3 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EDP43135.1 - 0.13 12.2 1.1 0.28 11.1 0.1 2.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family DUF3449 PF11931.8 EDP43135.1 - 0.39 10.5 4.1 29 4.4 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) TFA2_Winged_2 PF18121.1 EDP43136.1 - 2.8e-18 65.3 0.0 6.2e-18 64.2 0.0 1.6 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EDP43136.1 - 8.5e-05 22.8 0.1 0.00018 21.7 0.1 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain LRR_10 PF18805.1 EDP43136.1 - 0.019 14.6 0.0 0.089 12.5 0.0 2.0 2 0 0 2 2 2 0 Leucine-rich repeat Tyr-DNA_phospho PF06087.12 EDP43137.1 - 1.4e-17 63.8 0.0 1.6e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EDP43137.1 - 0.00047 20.1 0.0 0.00062 19.7 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain POPLD PF08170.12 EDP43142.1 - 5.5e-21 74.7 0.0 1.4e-20 73.4 0.0 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain POP1 PF06978.11 EDP43142.1 - 5e-10 39.7 0.9 9.3e-10 38.8 0.9 1.5 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 adh_short PF00106.25 EDP43143.1 - 0.00014 21.4 0.0 0.017 14.5 0.0 2.6 2 1 1 3 3 3 2 short chain dehydrogenase KR PF08659.10 EDP43143.1 - 0.0082 16.1 0.3 0.015 15.2 0.0 1.5 2 0 0 2 2 2 1 KR domain Transketolase_C PF02780.20 EDP43143.1 - 0.14 12.0 0.0 0.4 10.6 0.0 1.7 2 0 0 2 2 2 0 Transketolase, C-terminal domain DUF1681 PF07933.14 EDP43144.1 - 3.2e-37 127.5 0.0 3.6e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) DUF1983 PF09327.11 EDP43144.1 - 0.053 13.6 0.0 0.078 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1983) SSV1_ORF_D-335 PF07935.11 EDP43144.1 - 0.11 12.8 0.1 0.25 11.6 0.0 1.5 2 0 0 2 2 2 0 ORF D-335-like protein WD40 PF00400.32 EDP43145.1 - 5.2e-11 42.9 6.8 0.0016 19.2 0.1 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Epimerase PF01370.21 EDP43146.1 - 2.7e-14 53.2 0.0 6.3e-13 48.7 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP43146.1 - 3e-14 53.3 0.0 4.1e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EDP43146.1 - 8.6e-14 51.7 0.0 1.4e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EDP43146.1 - 1.4e-13 50.5 0.0 7.2e-12 44.9 0.0 2.3 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDP43146.1 - 2.7e-11 43.1 0.0 2.1e-09 36.9 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EDP43146.1 - 1.4e-10 40.7 0.5 0.00051 19.3 0.2 3.1 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EDP43146.1 - 1.4e-05 24.7 0.0 5.1e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EDP43146.1 - 0.00097 18.6 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP43146.1 - 0.0027 17.3 0.0 0.0064 16.1 0.0 1.6 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EDP43146.1 - 0.0073 15.5 0.0 0.018 14.2 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EDP43146.1 - 0.047 13.6 0.0 0.24 11.3 0.0 2.0 1 1 1 2 2 2 0 KR domain tRNA-synt_2b PF00587.25 EDP43146.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Mit_KHE1 PF10173.9 EDP43147.1 - 4.3e-50 170.4 1.7 6.1e-50 169.9 1.7 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Glyco_hydro_16 PF00722.21 EDP43148.1 - 8.4e-08 31.9 0.1 2.1e-07 30.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 tRNA-synt_2b PF00587.25 EDP43149.1 - 1.7e-33 116.1 0.0 2.5e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDP43149.1 - 0.00014 21.9 0.0 0.00034 20.7 0.0 1.6 1 1 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EDP43149.1 - 0.18 10.8 0.1 0.32 10.0 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Peptidase_M22 PF00814.25 EDP43150.1 - 8.4e-77 258.5 0.0 9.2e-76 255.1 0.0 1.9 1 1 0 1 1 1 1 Glycoprotease family Helicase_C PF00271.31 EDP43151.1 - 7.4e-12 45.6 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP43151.1 - 6.2e-05 22.8 0.0 0.00061 19.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase HLH PF00010.26 EDP43152.1 - 1.3e-17 63.5 1.9 3.4e-17 62.2 1.9 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5427 PF10310.9 EDP43152.1 - 3.3 6.5 4.6 16 4.3 0.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5427) Med21 PF11221.8 EDP43153.1 - 1.2e-10 41.8 0.4 2.1e-10 41.0 0.4 1.3 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF3135 PF11333.8 EDP43153.1 - 0.0049 17.1 0.2 0.013 15.8 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3135) GAT PF03127.14 EDP43153.1 - 0.017 15.4 0.2 0.045 14.1 0.0 1.7 2 0 0 2 2 2 0 GAT domain MitMem_reg PF13012.6 EDP43153.1 - 0.078 13.4 0.0 0.099 13.1 0.0 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Endosulfine PF04667.17 EDP43154.1 - 1.3e-26 92.6 0.7 2.3e-26 91.7 0.1 1.6 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region Porin_3 PF01459.22 EDP43155.1 - 1.7e-65 221.2 0.5 1.9e-65 221.0 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic porin DUF5477 PF17571.2 EDP43156.1 - 0.0054 16.9 1.1 0.013 15.7 1.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5477) CPSF_A PF03178.15 EDP43157.1 - 1.9e-42 145.8 0.0 4.1e-41 141.4 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 EDP43157.1 - 1.7e-22 79.7 0.0 2.7e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ig_C19orf38 PF17737.1 EDP43157.1 - 0.034 14.5 0.0 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 Ig domain in C19orf38 (HIDE1) WD40 PF00400.32 EDP43157.1 - 0.58 11.1 6.7 2.4 9.1 0.1 4.5 4 0 0 4 4 4 0 WD domain, G-beta repeat TPR_1 PF00515.28 EDP43158.1 - 9.8e-10 37.8 3.2 3.5e-05 23.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDP43158.1 - 1.6e-07 30.9 6.4 0.0015 18.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43158.1 - 0.00094 19.6 1.1 0.00094 19.6 1.1 2.4 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP43158.1 - 0.0012 19.1 0.3 0.0012 19.1 0.3 2.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDP43158.1 - 0.0012 19.0 1.3 0.0023 18.0 1.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDP43158.1 - 0.0014 18.9 1.3 0.073 13.5 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43158.1 - 0.0034 18.0 8.0 0.0034 18.0 2.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43158.1 - 0.0057 17.4 1.4 0.03 15.1 0.4 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDP43158.1 - 0.0093 15.9 1.6 0.033 14.2 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43158.1 - 0.08 13.2 0.5 17 6.0 0.0 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EDP43158.1 - 0.099 13.1 0.7 0.17 12.3 0.7 1.4 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_12 PF13424.6 EDP43158.1 - 0.71 10.2 7.1 1.5 9.1 3.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat AAA_11 PF13086.6 EDP43159.1 - 8.3e-68 229.0 0.1 1.4e-67 228.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EDP43159.1 - 5.4e-60 202.4 0.0 8.7e-60 201.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain SEN1_N PF12726.7 EDP43159.1 - 6.6e-21 74.2 0.3 1.3e-20 73.3 0.3 1.4 1 0 0 1 1 1 1 SEN1 N terminal AAA_30 PF13604.6 EDP43159.1 - 1.4e-12 47.7 0.0 7.8e-08 32.3 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDP43159.1 - 1.3e-08 35.3 0.0 4.1e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDP43159.1 - 9.4e-08 32.1 0.2 0.078 12.7 0.0 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EDP43159.1 - 0.00075 19.8 0.6 0.025 14.9 0.0 2.8 1 1 1 2 2 2 1 AAA domain UvrD-helicase PF00580.21 EDP43159.1 - 0.0083 15.7 0.0 0.2 11.1 0.0 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 EDP43159.1 - 0.02 15.3 0.6 0.1 13.0 0.6 2.3 1 1 0 1 1 1 0 AAA ATPase domain UvrD_C_2 PF13538.6 EDP43159.1 - 0.023 14.5 0.1 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA PF00004.29 EDP43159.1 - 0.033 14.6 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 EDP43159.1 - 0.039 13.3 0.1 0.7 9.2 0.0 2.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family Jnk-SapK_ap_N PF09744.9 EDP43159.1 - 0.16 12.2 4.8 0.38 11.0 4.8 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 C1_1 PF00130.22 EDP43160.1 - 1.6e-20 72.7 21.9 1.9e-11 43.7 4.9 2.2 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 EDP43160.1 - 3.9e-07 30.1 4.9 7.7e-07 29.1 4.9 1.5 1 0 0 1 1 1 1 Hr1 repeat C2 PF00168.30 EDP43160.1 - 0.001 19.3 0.0 0.0018 18.6 0.0 1.3 1 0 0 1 1 1 1 C2 domain C1_2 PF03107.16 EDP43160.1 - 0.44 10.9 19.3 2.5 8.5 6.4 2.3 2 0 0 2 2 2 0 C1 domain FYVE_2 PF02318.16 EDP43160.1 - 2 8.7 14.5 3.2 8.0 3.2 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger Pkinase PF00069.25 EDP43161.1 - 6.7e-64 215.8 0.0 8.1e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43161.1 - 1.8e-36 125.7 0.0 2.3e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43161.1 - 0.0015 17.9 0.0 0.0037 16.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDP43161.1 - 0.0017 18.0 0.4 0.28 10.8 0.1 2.1 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EDP43161.1 - 0.027 13.4 0.2 0.036 13.0 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EDP43161.1 - 0.045 12.5 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_S19e PF01090.19 EDP43162.1 - 3.7e-45 153.0 0.0 4.2e-45 152.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e RXT2_N PF08595.11 EDP43162.1 - 0.024 14.7 2.1 0.029 14.4 2.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 EDP43162.1 - 0.055 12.6 0.3 0.041 13.0 0.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Cwf_Cwc_15 PF04889.12 EDP43162.1 - 0.17 11.6 7.9 0.18 11.5 7.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EDP43162.1 - 6.2 6.0 11.4 7.2 5.8 11.4 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EDP43162.1 - 7.1 7.1 18.8 11 6.5 18.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RRM_1 PF00076.22 EDP43163.1 - 2e-09 37.1 0.0 6.4e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP43163.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RhoGAP PF00620.27 EDP43164.1 - 1.2e-08 34.9 0.1 2.6e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EDP43164.1 - 0.081 13.2 0.1 0.3 11.4 0.1 2.0 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain RIO1 PF01163.22 EDP43165.1 - 6.4e-70 234.6 0.0 1.4e-69 233.5 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 EDP43165.1 - 0.00075 18.9 0.6 0.0013 18.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EDP43165.1 - 0.0027 17.1 3.9 0.048 13.0 3.9 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DALR_1 PF05746.15 EDP43165.1 - 0.3 11.3 1.8 13 6.0 0.1 2.7 2 0 0 2 2 2 0 DALR anticodon binding domain Pkinase_fungal PF17667.1 EDP43165.1 - 0.78 8.4 9.3 0.044 12.6 1.0 2.4 2 0 0 2 2 2 0 Fungal protein kinase Hist_deacetyl PF00850.19 EDP43166.1 - 2e-28 99.8 0.1 3e-28 99.2 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain vATP-synt_AC39 PF01992.16 EDP43167.1 - 1.5e-113 379.8 0.3 1.7e-113 379.6 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit HA2 PF04408.23 EDP43168.1 - 2.5e-20 72.8 0.1 2.5e-20 72.8 0.1 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDP43168.1 - 2.3e-11 44.0 0.0 1.7e-10 41.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDP43168.1 - 3.1e-07 30.6 0.0 1.8e-06 28.2 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 EDP43168.1 - 1e-06 29.0 0.1 4.6e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EDP43168.1 - 1.4e-06 28.2 0.0 3.2e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EDP43168.1 - 0.0015 18.3 0.0 0.0038 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDP43168.1 - 0.012 15.9 3.5 0.023 15.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDP43168.1 - 0.061 13.8 0.0 0.061 13.8 0.0 2.9 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EDP43168.1 - 0.1 11.9 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 KaiC UDG PF03167.19 EDP43169.1 - 1.2e-17 64.4 0.0 2.4e-17 63.4 0.0 1.5 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily Yos1 PF08571.10 EDP43171.1 - 4.7e-21 74.8 0.9 6.9e-21 74.3 0.9 1.3 1 1 0 1 1 1 1 Yos1-like Hydrolase_6 PF13344.6 EDP43172.1 - 5.5e-19 68.2 0.0 1.1e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDP43172.1 - 2.9e-08 33.6 0.0 6.6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDP43172.1 - 0.012 15.9 0.0 3.3 7.9 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase OPT PF03169.15 EDP43174.1 - 2.8e-59 201.3 8.4 3.1e-59 201.2 8.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3429 PF11911.8 EDP43174.1 - 0.024 14.9 0.2 0.053 13.8 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3429) Colicin_V PF02674.16 EDP43174.1 - 0.036 14.0 1.8 6.6 6.7 0.1 2.6 2 0 0 2 2 2 0 Colicin V production protein SNARE_assoc PF09335.11 EDP43174.1 - 0.058 13.9 5.5 0.13 12.7 0.5 3.0 1 1 2 3 3 3 0 SNARE associated Golgi protein OPT PF03169.15 EDP43175.1 - 5.1e-73 246.7 22.7 5.8e-73 246.5 22.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Cohesin_HEAT PF12765.7 EDP43178.1 - 7.4e-10 39.0 0.0 7.4e-10 39.0 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 EDP43178.1 - 0.0043 17.2 7.7 10 6.7 0.2 4.9 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.7 EDP43178.1 - 0.0051 16.9 4.4 0.92 9.5 1.1 2.6 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Nipped-B_C PF12830.7 EDP43179.1 - 1.1e-45 156.0 1.2 2.8e-45 154.6 0.5 2.0 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Chitin_synth_2 PF03142.15 EDP43180.1 - 2.8e-228 758.8 0.0 3.6e-228 758.4 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 EDP43180.1 - 1.2e-13 50.8 0.0 4.9e-13 48.8 0.0 2.0 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 EDP43180.1 - 3.7e-10 40.1 0.0 3e-08 33.8 0.0 2.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 EDP43180.1 - 5.2e-09 36.1 0.0 4.6e-07 29.9 0.0 2.8 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 EDP43180.1 - 5.4e-09 36.3 1.9 1.6e-08 34.7 1.9 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EDP43180.1 - 0.00013 21.8 0.0 0.1 12.4 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDP43180.1 - 0.005 16.3 0.0 0.1 12.0 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Pkinase PF00069.25 EDP43181.1 - 1.6e-67 227.7 0.0 1.9e-67 227.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43181.1 - 5.3e-32 111.1 0.0 7e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDP43181.1 - 0.0008 18.8 0.3 0.0016 17.8 0.3 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP43181.1 - 0.0032 17.4 0.4 0.061 13.2 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP43181.1 - 0.008 15.2 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDP43181.1 - 0.014 14.2 0.0 0.017 13.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EDP43181.1 - 0.014 15.0 0.1 0.023 14.3 0.1 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EDP43181.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like YukC PF10140.9 EDP43181.1 - 0.056 12.3 0.0 0.077 11.8 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Sel1 PF08238.12 EDP43182.1 - 3.1e-11 43.6 14.7 2.3e-05 24.9 0.1 6.4 6 0 0 6 6 6 2 Sel1 repeat TPR_2 PF07719.17 EDP43182.1 - 0.0014 18.6 0.1 0.046 13.9 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43182.1 - 0.073 13.3 0.0 0.8 10.1 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_S64 PF08192.11 EDP43182.1 - 3.4 6.0 4.6 5.1 5.5 4.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 ERM PF00769.19 EDP43182.1 - 5 6.9 19.8 2.7 7.7 15.4 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family eIF-5a PF01287.20 EDP43183.1 - 1.5e-29 101.8 0.4 2e-29 101.5 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Tube PF17212.3 EDP43183.1 - 0.03 14.4 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Tail tubular protein HLH PF00010.26 EDP43184.1 - 4.1e-14 52.3 0.1 8.4e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TolA_bind_tri PF16331.5 EDP43184.1 - 0.02 15.0 1.1 0.056 13.5 1.1 1.7 1 0 0 1 1 1 0 TolA binding protein trimerisation MCC-bdg_PDZ PF10506.9 EDP43184.1 - 0.073 13.1 0.6 0.15 12.1 0.6 1.5 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Telomere_reg-2 PF10193.9 EDP43185.1 - 8.8e-29 100.1 0.1 2.1e-28 98.9 0.1 1.7 1 0 0 1 1 1 1 Telomere length regulation protein NAD_binding_7 PF13241.6 EDP43186.1 - 9.7e-30 103.1 0.0 1.7e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EDP43186.1 - 3.6e-20 71.4 0.5 6e-20 70.7 0.5 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EDP43186.1 - 9.7e-13 47.3 0.2 1.7e-12 46.6 0.2 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 EDP43186.1 - 0.04 13.2 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pil1 PF13805.6 EDP43187.1 - 1.2e-24 87.2 3.5 1.8e-24 86.7 3.5 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 Ribonuc_P_40 PF08584.11 EDP43188.1 - 4.7e-47 160.6 0.0 4.9e-46 157.3 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit TEA PF01285.18 EDP43189.1 - 5.7e-30 103.2 0.0 1.2e-29 102.2 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain Sec1 PF00995.23 EDP43190.1 - 2.5e-104 350.6 0.0 3.1e-104 350.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family 4HBT PF03061.22 EDP43190.1 - 0.081 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Thioesterase superfamily tRNA-synt_1e PF01406.19 EDP43191.1 - 3.4e-123 410.8 0.0 1.1e-122 409.1 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EDP43191.1 - 4.8e-09 35.5 0.4 0.00015 20.6 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDP43191.1 - 4.3e-07 28.6 0.4 0.0066 14.7 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 EDP43191.1 - 3.8e-05 22.7 0.5 0.0017 17.3 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain DALR_2 PF09190.11 EDP43191.1 - 0.00018 21.9 0.0 0.0012 19.3 0.0 2.4 2 0 0 2 2 2 1 DALR domain Aspzincin_M35 PF14521.6 EDP43191.1 - 0.036 14.6 0.0 0.083 13.4 0.0 1.5 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase tRNA-synt_1f PF01921.18 EDP43191.1 - 0.044 12.7 0.1 5.9 5.7 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (K) EGL-1 PF11430.8 EDP43191.1 - 0.64 9.9 2.8 1.4 8.9 2.8 1.5 1 0 0 1 1 1 0 Programmed cell death activator EGL-1 TetR_C_1 PF02909.17 EDP43191.1 - 1 9.1 4.7 5.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Exo_endo_phos PF03372.23 EDP43192.1 - 5.1e-09 36.0 0.1 2.1e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RAB3GAP2_N PF14655.6 EDP43192.1 - 0.11 11.7 0.0 13 4.9 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus LUC7 PF03194.15 EDP43193.1 - 2.7e-49 168.1 2.3 4.6e-49 167.3 0.9 1.7 1 1 1 2 2 2 1 LUC7 N_terminus AAA_13 PF13166.6 EDP43193.1 - 0.048 12.3 3.7 5.2 5.6 3.6 1.9 1 1 1 2 2 2 0 AAA domain Prominin PF05478.11 EDP43193.1 - 0.055 11.4 0.1 0.079 10.9 0.1 1.2 1 0 0 1 1 1 0 Prominin FapA PF03961.13 EDP43193.1 - 0.066 11.8 1.0 0.079 11.5 1.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMCO5 PF14992.6 EDP43193.1 - 0.54 9.8 6.3 0.77 9.3 6.3 1.1 1 0 0 1 1 1 0 TMCO5 family APG6_N PF17675.1 EDP43193.1 - 1.1 9.8 9.2 1.8 9.1 9.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 EDP43193.1 - 1.7 8.9 9.5 0.97 9.7 0.4 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Thymidylate_kin PF02223.17 EDP43194.1 - 5.5e-43 146.8 0.0 7.4e-43 146.4 0.0 1.2 1 0 0 1 1 1 1 Thymidylate kinase Hydrolase_4 PF12146.8 EDP43194.1 - 0.00034 20.0 1.0 0.00074 18.9 0.3 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 AAA_33 PF13671.6 EDP43194.1 - 0.0028 17.8 0.0 0.016 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDP43194.1 - 0.01 16.1 0.1 0.016 15.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain FSH1 PF03959.13 EDP43194.1 - 0.032 13.9 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PRK PF00485.18 EDP43194.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family KTI12 PF08433.10 EDP43194.1 - 0.24 10.8 0.0 0.45 9.9 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 CSTF2_hinge PF14327.6 EDP43195.1 - 1.8e-31 108.4 1.8 1.8e-31 108.4 1.8 2.2 2 1 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 EDP43195.1 - 6e-16 57.7 12.9 2.2e-14 52.7 8.5 2.4 2 0 0 2 2 2 2 Transcription termination and cleavage factor C-terminal FliG_N PF14842.6 EDP43195.1 - 0.092 13.3 1.0 19 5.8 0.0 2.9 2 1 1 3 3 3 0 FliG N-terminal domain Prefoldin_2 PF01920.20 EDP43196.1 - 6.6e-07 29.2 10.7 0.002 18.1 0.3 2.0 2 0 0 2 2 2 2 Prefoldin subunit Tropomyosin PF00261.20 EDP43196.1 - 0.023 14.0 3.7 0.023 14.0 3.7 1.9 2 0 0 2 2 2 0 Tropomyosin DHR10 PF18595.1 EDP43196.1 - 4.7 7.3 14.1 9.3 6.3 1.4 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain B56 PF01603.20 EDP43197.1 - 2.9e-188 626.0 7.4 3.5e-188 625.8 7.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Herpes_UL21 PF03252.13 EDP43197.1 - 0.08 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL21 Sec66 PF09802.9 EDP43198.1 - 5.8e-34 117.2 0.3 7.1e-34 117.0 0.3 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 CK_II_beta PF01214.18 EDP43199.1 - 1.1e-35 123.1 0.0 1.6e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Transket_pyr PF02779.24 EDP43200.1 - 4e-49 166.7 0.1 5.7e-49 166.2 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDP43200.1 - 9.5e-40 135.3 0.0 1.9e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EDP43200.1 - 0.056 13.8 0.0 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II Pyrophosphatase PF00719.19 EDP43201.1 - 3e-58 196.2 0.2 4.2e-58 195.7 0.2 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase peroxidase PF00141.23 EDP43202.1 - 1.6e-45 155.6 0.0 2.4e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Peroxidase DUF4003 PF13170.6 EDP43202.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) Rgp1 PF08737.10 EDP43203.1 - 0.0095 15.2 0.1 0.017 14.3 0.1 1.3 1 0 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 EDP43203.1 - 0.054 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain He_PIG PF05345.12 EDP43204.1 - 0.73 10.1 0.0 0.73 10.1 0.0 3.6 4 0 0 4 4 4 0 Putative Ig domain E1-E2_ATPase PF00122.20 EDP43205.1 - 2.2e-51 174.0 2.2 7.4e-51 172.2 0.8 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EDP43205.1 - 4.8e-49 166.5 4.8 1.2e-48 165.3 3.0 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EDP43205.1 - 3.5e-24 86.3 1.0 1.2e-23 84.5 1.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDP43205.1 - 1.3e-16 60.4 0.0 2.5e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EDP43205.1 - 5.6e-10 39.4 0.9 1.4e-07 31.5 1.7 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EDP43205.1 - 4.5e-05 23.9 0.0 0.0001 22.7 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase L31 PF09784.9 EDP43206.1 - 8.4e-40 135.3 0.2 9.5e-40 135.2 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 F_bP_aldolase PF01116.20 EDP43207.1 - 8.9e-95 317.4 0.0 1e-94 317.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Lipase_GDSL_2 PF13472.6 EDP43207.1 - 0.037 14.4 0.1 0.075 13.4 0.1 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family GLTP PF08718.11 EDP43208.1 - 6.3e-47 159.6 0.0 8.5e-47 159.2 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Fasciclin PF02469.22 EDP43209.1 - 1.2e-53 180.7 1.5 6.4e-12 45.8 0.0 6.2 5 2 0 5 5 5 5 Fasciclin domain Radical_SAM_C PF16199.5 EDP43210.1 - 3.6e-31 107.0 0.0 1.2e-30 105.4 0.0 1.9 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EDP43210.1 - 2.8e-17 63.6 0.1 8.8e-17 62.0 0.1 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EDP43210.1 - 1.6e-07 31.5 0.0 3.3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDP43210.1 - 4e-06 26.8 0.0 8.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDP43210.1 - 0.014 15.9 0.0 0.035 14.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDP43210.1 - 0.12 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Myotub-related PF06602.14 EDP43211.1 - 2.1e-07 30.2 0.0 2.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Myotub-related PF06602.14 EDP43212.1 - 8.2e-120 399.9 0.3 1e-119 399.6 0.3 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 EDP43212.1 - 0.00017 21.2 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDP43212.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EDP43212.1 - 0.086 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family LRR_6 PF13516.6 EDP43213.1 - 1.7e-10 40.1 19.8 0.012 15.6 0.1 8.0 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.7 EDP43213.1 - 0.0002 21.6 19.0 0.97 10.0 2.9 6.5 4 2 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDP43213.1 - 0.00038 20.6 8.2 5.7 7.9 0.4 6.7 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.6 EDP43213.1 - 0.05 13.4 17.6 1.6 8.6 0.4 5.7 3 2 3 6 6 6 0 Leucine rich repeat DUF5089 PF17002.5 EDP43213.1 - 0.12 12.2 5.4 0.19 11.6 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) NOA36 PF06524.12 EDP43213.1 - 0.31 10.3 12.6 0.47 9.7 12.6 1.2 1 0 0 1 1 1 0 NOA36 protein PTPRCAP PF15713.5 EDP43213.1 - 1.3 9.3 14.8 2.4 8.4 14.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 EDP43213.1 - 3.8 5.7 13.2 5.7 5.1 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Lactamase_B_2 PF12706.7 EDP43214.1 - 6.3e-24 84.6 0.0 1.5e-23 83.4 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDP43214.1 - 2.2e-06 27.8 0.0 4.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily WD40 PF00400.32 EDP43215.1 - 2.4e-17 63.0 7.4 0.00057 20.6 0.0 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ_2 PF13360.6 EDP43215.1 - 9.5e-06 25.4 2.2 0.00044 19.9 1.0 3.2 1 1 0 2 2 2 1 PQQ-like domain PQQ_3 PF13570.6 EDP43215.1 - 1.1e-05 25.8 2.2 0.069 13.7 0.1 4.5 5 0 0 5 5 5 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EDP43215.1 - 4.2e-05 23.8 0.0 8.7 6.7 0.0 4.1 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EDP43215.1 - 0.11 12.5 0.5 5.6 7.1 0.0 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5046 PF16465.5 EDP43215.1 - 0.14 11.6 0.1 0.54 9.7 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5046) FMO-like PF00743.19 EDP43216.1 - 9.3e-19 67.2 0.0 1.5e-12 46.8 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDP43216.1 - 1.1e-07 31.4 0.0 5.3e-07 29.2 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EDP43216.1 - 0.00014 21.2 0.0 0.00085 18.6 0.0 2.2 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EDP43216.1 - 0.00014 21.2 0.0 0.0021 17.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDP43217.1 - 9.1e-10 38.6 0.0 1.1e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EDP43217.1 - 5.3e-07 29.7 0.0 8.1e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EDP43217.1 - 7.7e-05 22.1 0.0 8.5e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EDP43217.1 - 0.0003 20.1 0.1 0.00035 19.9 0.1 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EDP43217.1 - 0.00067 19.3 0.4 0.00085 19.0 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FMO-like PF00743.19 EDP43217.1 - 0.0015 17.0 0.0 0.0018 16.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EDP43217.1 - 0.0038 16.5 0.2 0.0045 16.3 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EDP43217.1 - 0.004 16.0 0.0 0.0044 15.9 0.0 1.0 1 0 0 1 1 1 1 MCRA family HI0933_like PF03486.14 EDP43217.1 - 0.0041 15.9 0.5 0.005 15.6 0.5 1.1 1 0 0 1 1 1 1 HI0933-like protein Amino_oxidase PF01593.24 EDP43217.1 - 0.0046 16.3 0.0 0.0055 16.0 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EDP43217.1 - 0.0063 15.9 0.0 0.0063 15.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EDP43217.1 - 0.025 13.9 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EDP43217.1 - 0.045 12.8 0.1 0.051 12.6 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EDP43217.1 - 0.077 12.1 0.7 0.085 11.9 0.7 1.1 1 0 0 1 1 1 0 FAD binding domain K_oxygenase PF13434.6 EDP43217.1 - 0.086 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EDP43217.1 - 0.092 13.3 0.0 0.12 13.0 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EDP43217.1 - 0.2 10.4 0.3 0.23 10.2 0.3 1.0 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 EDP43217.1 - 0.31 10.1 0.7 0.34 9.9 0.7 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Pkinase PF00069.25 EDP43218.1 - 2.2e-24 86.3 0.0 2.8e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43218.1 - 6.7e-12 45.2 0.0 9.8e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP43218.1 - 5.7e-06 25.4 0.0 8e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDP43218.1 - 0.021 14.7 0.0 4 7.3 0.0 2.4 1 1 0 2 2 2 0 Phosphotransferase enzyme family zf-Tim10_DDP PF02953.15 EDP43219.1 - 1.2e-19 69.7 0.5 1.2e-19 69.7 0.5 1.7 2 0 0 2 2 2 1 Tim10/DDP family zinc finger DNA_pol_phi PF04931.13 EDP43220.1 - 3.9e-208 693.2 1.9 1.4e-205 684.8 0.3 2.1 2 0 0 2 2 2 2 DNA polymerase phi BUD22 PF09073.10 EDP43220.1 - 0.00088 18.7 15.7 0.00088 18.7 15.7 3.0 4 0 0 4 4 4 1 BUD22 DUF1117 PF06547.12 EDP43220.1 - 8.2 7.0 5.8 3 8.4 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1117) Rhodanese PF00581.20 EDP43221.1 - 4.9e-09 36.7 0.0 1.3e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain PUF PF00806.19 EDP43223.1 - 7e-24 82.1 0.0 0.00057 19.4 0.0 6.1 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EDP43223.1 - 3.3e-11 42.8 0.0 1.1e-05 25.1 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP43223.1 - 0.00027 20.7 0.0 0.0017 18.2 0.0 2.1 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_1 PF00076.22 EDP43224.1 - 6.2e-19 67.6 0.0 5e-13 48.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP43224.1 - 0.0051 16.9 0.0 0.086 13.0 0.0 2.4 2 1 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 EDP43224.1 - 0.014 15.0 0.0 0.88 9.2 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA_bind_3 PF17176.4 EDP43224.1 - 0.093 13.0 0.1 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 tRNA-binding domain zf-C2H2_4 PF13894.6 EDP43225.1 - 2.6e-05 24.7 6.1 0.012 16.4 1.7 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EDP43225.1 - 0.0018 18.7 9.5 0.44 11.1 0.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EDP43225.1 - 0.91 9.6 5.3 7.2 6.7 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger SAP PF02037.27 EDP43226.1 - 2.3e-05 24.0 0.1 4.7e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 SAP domain zf-WRNIP1_ubi PF18279.1 EDP43226.1 - 0.00047 20.6 0.2 0.0011 19.4 0.2 1.6 1 0 0 1 1 1 1 Werner helicase-interacting protein 1 ubiquitin-binding domain TRAF6_Z2 PF18048.1 EDP43226.1 - 0.00066 19.7 0.3 0.0012 18.9 0.3 1.3 1 0 0 1 1 1 1 TNF receptor-associated factor 6 zinc finger 2 zf-Di19 PF05605.12 EDP43226.1 - 0.0048 17.2 0.8 0.033 14.5 0.2 2.3 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EDP43226.1 - 0.018 14.6 1.1 0.035 13.7 0.3 2.0 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Prok-RING_4 PF14447.6 EDP43226.1 - 0.075 12.9 0.2 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zinc_ribbon_4 PF13717.6 EDP43226.1 - 0.097 12.6 0.1 3 7.8 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Rad50_zn_hook PF04423.14 EDP43226.1 - 0.12 12.2 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif MFS_1 PF07690.16 EDP43227.1 - 1.4e-19 70.3 14.5 1.4e-19 70.3 14.5 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily ERG2_Sigma1R PF04622.12 EDP43228.1 - 3.1e-88 294.6 0.0 3.9e-88 294.2 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein G0-G1_switch_2 PF15103.6 EDP43228.1 - 0.046 14.2 0.0 0.079 13.4 0.0 1.3 1 0 0 1 1 1 0 G0/G1 switch protein 2 Spc24 PF08286.11 EDP43229.1 - 2.1e-06 27.9 1.7 2.2e-06 27.9 1.7 1.0 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 HMMR_N PF15905.5 EDP43229.1 - 0.046 13.2 1.5 0.045 13.2 1.5 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HECW_N PF16562.5 EDP43229.1 - 0.059 13.2 0.2 0.065 13.0 0.2 1.0 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 CAF1A PF12253.8 EDP43230.1 - 8.7e-21 73.9 1.0 8.7e-21 73.9 1.0 2.7 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A CDC27 PF09507.10 EDP43230.1 - 6.1 6.1 21.8 0.022 14.2 11.3 2.0 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 AAA PF00004.29 EDP43231.1 - 1.1e-15 58.2 0.0 2.7e-15 56.9 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDP43231.1 - 2.6e-12 46.8 0.0 1.1e-09 38.3 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EDP43231.1 - 2.1e-11 44.1 0.0 4.6e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 EDP43231.1 - 2.6e-07 30.7 0.0 7.2e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_11 PF13086.6 EDP43231.1 - 5.7e-06 26.3 0.0 1.2e-05 25.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDP43231.1 - 1.7e-05 25.1 0.0 0.00098 19.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EDP43231.1 - 8.4e-05 23.0 0.0 0.0005 20.5 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EDP43231.1 - 0.0001 22.1 0.1 0.00024 20.9 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EDP43231.1 - 0.00022 20.7 0.0 0.0039 16.6 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDP43231.1 - 0.00048 20.2 0.0 0.0016 18.4 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP43231.1 - 0.00057 19.6 0.0 0.002 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EDP43231.1 - 0.00068 19.4 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDP43231.1 - 0.00074 19.6 0.0 0.0037 17.3 0.0 1.9 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 EDP43231.1 - 0.0011 18.9 0.0 0.0053 16.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 EDP43231.1 - 0.0022 18.3 0.0 0.0051 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 EDP43231.1 - 0.0034 17.7 0.0 0.033 14.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 EDP43231.1 - 0.0058 16.9 0.0 0.024 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDP43231.1 - 0.0069 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 EDP43231.1 - 0.0092 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DEAD PF00270.29 EDP43231.1 - 0.023 14.5 0.0 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.6 EDP43231.1 - 0.03 14.9 0.0 0.14 12.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EDP43231.1 - 0.059 13.2 0.0 0.29 11.0 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EDP43231.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 EDP43231.1 - 0.084 12.3 0.0 2.3 7.6 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 EDP43231.1 - 0.12 11.5 0.0 0.6 9.3 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 EDP43231.1 - 0.13 11.8 0.1 0.46 10.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDP43231.1 - 0.2 12.1 0.0 0.29 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDP43231.1 - 0.2 12.0 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Ribosomal_S6 PF01250.17 EDP43232.1 - 1.8e-06 28.1 0.0 2.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 AA_kinase PF00696.28 EDP43233.1 - 1.7e-39 135.9 0.2 2.2e-39 135.5 0.2 1.1 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EDP43233.1 - 1.6e-14 53.6 2.6 3.3e-14 52.6 0.0 2.7 3 1 0 3 3 3 1 PUA domain WD40 PF00400.32 EDP43234.1 - 7.5e-10 39.2 6.4 0.00014 22.6 0.0 7.4 7 1 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43234.1 - 1.5e-05 25.2 0.0 0.016 15.5 0.0 4.8 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EDP43234.1 - 0.0015 18.9 0.4 0.18 12.4 0.0 4.0 2 0 0 2 2 2 1 PQQ-like domain DEAD PF00270.29 EDP43236.1 - 1.3e-35 122.8 0.2 2.1e-35 122.1 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDP43236.1 - 1.1e-06 28.8 0.0 2.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDP43236.1 - 0.0057 16.9 0.6 0.041 14.2 0.6 2.3 1 1 0 1 1 1 1 AAA domain SRP-alpha_N PF04086.13 EDP43236.1 - 2.5 8.0 11.9 0.65 9.9 8.5 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal CAP_N PF01213.19 EDP43237.1 - 0.47 9.9 7.3 0.85 9.0 7.3 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CTP_transf_like PF01467.26 EDP43238.1 - 3.7e-28 98.5 0.0 4.5e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Laminin_G_3 PF13385.6 EDP43239.1 - 8.2e-14 52.0 1.5 3.1e-13 50.1 1.5 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Metallophos PF00149.28 EDP43239.1 - 5.7e-06 27.0 0.5 5.7e-06 27.0 0.5 2.1 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Laminin_G_2 PF02210.24 EDP43239.1 - 0.037 14.6 0.0 0.078 13.6 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain DEAD PF00270.29 EDP43241.1 - 1.4e-37 129.2 0.1 3.1e-37 128.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43241.1 - 2e-18 66.7 0.0 6.2e-18 65.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43241.1 - 0.0042 17.1 0.0 1.6 8.7 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDP43241.1 - 0.036 13.3 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Maelstrom PF13017.6 EDP43241.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 piRNA pathway germ-plasm component ORC_WH_C PF18137.1 EDP43242.1 - 3.7e-27 95.1 0.0 7.7e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal RE_TaqI PF09573.10 EDP43242.1 - 0.0075 16.1 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 TaqI restriction endonuclease ORC3_N PF07034.11 EDP43242.1 - 0.11 11.5 6.6 0.22 10.6 0.0 4.1 5 1 0 5 5 5 0 Origin recognition complex (ORC) subunit 3 N-terminus CDP-OH_P_transf PF01066.21 EDP43243.1 - 6.9e-13 49.2 0.6 6.9e-13 49.2 0.6 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CAP_N PF01213.19 EDP43243.1 - 0.1 12.0 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_carr PF00153.27 EDP43244.1 - 2.4e-22 78.7 0.6 9.1e-11 41.5 0.1 2.8 2 1 0 2 2 2 2 Mitochondrial carrier protein NPR2 PF06218.11 EDP43245.1 - 3.8e-83 279.7 1.1 5.3e-36 124.3 0.2 4.1 2 2 1 3 3 3 3 Nitrogen permease regulator 2 NPR3 PF03666.13 EDP43245.1 - 4.5e-07 29.0 0.4 0.00033 19.6 0.0 2.6 2 1 1 3 3 3 3 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_M28 PF04389.17 EDP43246.1 - 0.0053 16.5 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Prion_bPrPp PF11587.8 EDP43246.1 - 0.16 11.8 0.2 0.28 11.1 0.2 1.4 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal DEAD PF00270.29 EDP43247.1 - 0.00013 21.8 0.0 0.00049 19.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD PF00270.29 EDP43248.1 - 7.5e-29 100.7 0.3 2.6e-28 99.0 0.3 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EDP43248.1 - 1.5e-11 44.6 0.0 2.6e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP43248.1 - 7.5e-07 29.5 0.0 9.2e-06 26.0 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Sec63 PF02889.16 EDP43248.1 - 0.00013 21.3 0.0 0.00025 20.3 0.0 1.5 1 0 0 1 1 1 1 Sec63 Brl domain AAA_22 PF13401.6 EDP43248.1 - 0.0011 19.2 0.1 0.0045 17.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain SNF2_N PF00176.23 EDP43248.1 - 0.022 13.5 0.1 0.035 12.8 0.1 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain TniB PF05621.11 EDP43248.1 - 0.024 14.0 0.3 1.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_11 PF13086.6 EDP43248.1 - 0.056 13.2 0.0 0.15 11.9 0.0 1.7 1 1 1 2 2 2 0 AAA domain Sigma54_DBD PF04552.13 EDP43248.1 - 0.083 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-54, DNA binding domain AhpC-TSA PF00578.21 EDP43249.1 - 0.00081 19.3 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDP43249.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.5 2 0 0 2 2 2 0 Redoxin PTPLA PF04387.14 EDP43250.1 - 1.2e-45 155.2 5.2 1.5e-45 154.9 5.2 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Glyco_transf_22 PF03901.17 EDP43251.1 - 1.8e-31 109.8 23.8 2.2e-31 109.5 23.8 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SNF2_N PF00176.23 EDP43252.1 - 3.8e-70 236.4 0.0 5.3e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EDP43252.1 - 3.1e-19 68.7 0.0 8.6e-19 67.3 0.0 1.8 1 0 0 1 1 1 1 HIRAN domain ResIII PF04851.15 EDP43252.1 - 1.2e-07 31.8 0.0 5e-07 29.9 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP43252.1 - 3.4e-07 30.6 0.0 2e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP43252.1 - 1.9e-05 24.5 0.0 4.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_3 PF13920.6 EDP43252.1 - 0.00023 20.9 13.2 0.00023 20.9 13.2 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP43252.1 - 0.0031 17.8 15.3 0.011 16.0 15.3 2.1 1 0 0 1 1 1 1 Ring finger domain ADH_zinc_N PF00107.26 EDP43252.1 - 0.13 12.3 0.0 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase zf-C3HC4_2 PF13923.6 EDP43252.1 - 1.8 8.5 16.1 7.1 6.6 16.1 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP43252.1 - 1.8 8.5 21.6 0.063 13.2 14.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP43252.1 - 3 7.9 22.2 0.53 10.3 15.0 2.5 2 0 0 2 2 2 0 zinc-RING finger domain ANAPC10 PF03256.16 EDP43254.1 - 3.7e-36 124.5 0.0 1.9e-35 122.2 0.0 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) NIF PF03031.18 EDP43255.1 - 7.6e-25 87.5 0.0 1.7e-24 86.3 0.0 1.6 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Adaptin_binding PF10199.9 EDP43255.1 - 0.005 17.4 1.9 0.0085 16.7 1.9 1.4 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 FAM70 PF14967.6 EDP43255.1 - 0.24 10.8 0.4 0.36 10.3 0.4 1.2 1 0 0 1 1 1 0 FAM70 protein Neugrin PF06413.11 EDP43255.1 - 0.44 10.5 8.0 0.74 9.8 8.0 1.2 1 0 0 1 1 1 0 Neugrin PTCB-BRCT PF12738.7 EDP43256.1 - 1e-06 28.6 0.0 1.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EDP43256.1 - 5.4e-06 26.7 0.0 9.5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EDP43256.1 - 0.0099 16.2 0.3 0.028 14.7 0.3 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain WD40 PF00400.32 EDP43257.1 - 1.1e-15 57.7 8.2 0.16 12.9 0.0 8.0 7 0 0 7 7 7 5 WD domain, G-beta repeat VID27 PF08553.10 EDP43257.1 - 0.23 10.5 0.0 0.44 9.5 0.0 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain CbiX PF01903.17 EDP43258.1 - 0.12 12.7 15.2 0.57 10.5 0.5 4.5 2 1 2 4 4 4 0 CbiX GalP_UDP_tr_C PF02744.17 EDP43259.1 - 4.5e-48 163.1 0.0 7.4e-48 162.4 0.0 1.4 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.22 EDP43259.1 - 1.2e-17 64.9 0.1 2.4e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain DUF4921 PF16268.5 EDP43259.1 - 0.00026 19.9 0.0 0.00034 19.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4921) dCMP_cyt_deam_1 PF00383.23 EDP43260.1 - 1.2e-24 86.1 1.5 2e-24 85.4 1.5 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDP43260.1 - 8.1e-09 35.4 0.1 1.2e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EDP43260.1 - 0.045 13.9 0.5 0.091 12.9 0.5 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EDP43260.1 - 0.12 12.5 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 APOBEC3 APOBEC4_like PF18774.1 EDP43260.1 - 0.17 11.8 0.1 0.27 11.2 0.1 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase tRNA-synt_2b PF00587.25 EDP43261.1 - 1.1e-23 84.1 0.0 3e-22 79.4 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) FLILHELTA PF10306.9 EDP43261.1 - 8.3e-12 45.3 0.0 2.3e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA CENP-F_leu_zip PF10473.9 EDP43261.1 - 0.34 10.9 2.6 0.63 10.1 2.1 1.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JmjC PF02373.22 EDP43262.1 - 6.9e-40 136.0 0.2 1.3e-39 135.1 0.2 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 EDP43262.1 - 4e-14 52.3 0.1 7.4e-14 51.4 0.1 1.5 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.6 EDP43262.1 - 7.9e-12 45.3 2.4 7.9e-12 45.3 2.4 2.0 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EDP43262.1 - 5.5e-11 42.6 2.8 5.5e-11 42.6 2.8 1.8 2 0 0 2 2 2 1 PHD-zinc-finger like domain C1_2 PF03107.16 EDP43262.1 - 0.13 12.6 2.1 0.27 11.6 0.8 2.3 2 0 0 2 2 2 0 C1 domain PHD PF00628.29 EDP43262.1 - 0.23 11.4 5.1 0.08 12.9 1.8 2.0 2 0 0 2 2 2 0 PHD-finger VWC PF00093.18 EDP43262.1 - 0.25 11.7 2.3 0.71 10.2 2.3 1.7 1 0 0 1 1 1 0 von Willebrand factor type C domain Rhodanese_C PF12368.8 EDP43262.1 - 2.1 8.8 5.3 0.81 10.1 1.0 2.5 3 0 0 3 3 3 0 Rhodanase C-terminal TPT PF03151.16 EDP43263.1 - 3e-22 79.3 21.8 4.2e-22 78.9 21.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Zn_ribbon_17 PF17120.5 EDP43264.1 - 0.0034 17.0 3.1 0.0034 17.0 3.1 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EDP43264.1 - 0.014 15.3 0.8 0.014 15.3 0.8 2.7 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EDP43264.1 - 0.017 15.2 6.1 0.017 15.2 6.1 2.2 2 0 0 2 2 2 0 KIAA1045 RING finger C1_2 PF03107.16 EDP43264.1 - 0.024 15.0 1.4 0.024 15.0 1.4 2.1 2 0 0 2 2 2 0 C1 domain Prok-RING_1 PF14446.6 EDP43264.1 - 0.027 14.4 1.4 0.027 14.4 1.4 2.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Cytochrom_CIII PF02085.16 EDP43264.1 - 0.16 12.3 5.7 0.45 10.9 1.1 2.5 2 0 0 2 2 2 0 Class III cytochrome C family Rubredoxin PF00301.20 EDP43264.1 - 0.64 10.1 0.1 0.64 10.1 0.1 2.5 3 0 0 3 3 3 0 Rubredoxin PHD_4 PF16866.5 EDP43264.1 - 3.3 7.9 15.1 0.035 14.2 3.6 2.9 2 1 1 3 3 3 0 PHD-finger PHD PF00628.29 EDP43264.1 - 9.4 6.2 14.7 0.086 12.7 5.5 2.4 2 1 0 2 2 2 0 PHD-finger zf-NF-X1 PF01422.17 EDP43265.1 - 0.031 14.3 15.2 0.031 14.3 15.2 3.7 3 0 0 3 3 3 0 NF-X1 type zinc finger Mito_carr PF00153.27 EDP43266.1 - 1.1e-15 57.3 0.2 1.4e-15 57.0 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein UME PF08064.13 EDP43266.1 - 0.059 13.3 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 UME (NUC010) domain Mito_carr PF00153.27 EDP43267.1 - 6.3e-23 80.5 1.0 3.3e-15 55.8 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Sulfate_transp PF00916.20 EDP43267.1 - 0.12 11.0 2.8 4.3 6.0 0.0 2.1 2 0 0 2 2 2 0 Sulfate permease family Ras PF00071.22 EDP43268.1 - 5.9e-65 217.8 0.9 7.8e-65 217.4 0.9 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP43268.1 - 9.1e-37 125.9 0.1 2e-36 124.8 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP43268.1 - 9.1e-18 64.3 0.1 1.3e-17 63.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDP43268.1 - 5.8e-08 32.8 1.3 0.00052 20.0 0.3 2.2 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EDP43268.1 - 1.3e-05 24.7 0.1 1.7e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EDP43268.1 - 1.4e-05 24.7 0.4 3.5e-05 23.4 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDP43268.1 - 2.6e-05 23.7 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDP43268.1 - 4.1e-05 23.6 1.4 5.4e-05 23.3 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EDP43268.1 - 0.003 17.3 0.4 0.16 11.8 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain FeoB_N PF02421.18 EDP43268.1 - 0.0045 16.5 0.1 0.031 13.8 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EDP43268.1 - 0.0064 16.9 0.7 0.0086 16.5 0.0 1.7 2 1 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 EDP43268.1 - 0.011 16.1 0.1 0.78 10.2 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDP43268.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EDP43268.1 - 0.022 15.3 1.6 0.42 11.1 1.6 2.4 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 EDP43268.1 - 0.024 13.9 0.1 0.18 11.0 0.0 2.0 2 0 0 2 2 2 0 Septin AAA_22 PF13401.6 EDP43268.1 - 0.062 13.6 0.0 0.062 13.6 0.0 2.0 2 1 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EDP43268.1 - 0.063 12.8 0.0 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 EDP43268.1 - 0.08 12.3 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 EDP43268.1 - 0.097 12.4 0.1 1.6 8.5 0.0 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EDP43268.1 - 0.15 11.7 2.0 1.3 8.6 0.2 2.9 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EDP43268.1 - 0.33 10.9 1.2 0.34 10.8 0.0 1.6 2 0 0 2 2 1 0 NACHT domain Sec7 PF01369.20 EDP43269.1 - 2e-64 216.7 0.0 3.2e-64 216.0 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EDP43269.1 - 1.8e-15 57.2 0.1 6.9e-15 55.3 0.1 2.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Med31 PF05669.12 EDP43270.1 - 1.2e-32 111.7 5.4 1.6e-32 111.4 5.4 1.1 1 0 0 1 1 1 1 SOH1 AAR2 PF05282.11 EDP43271.1 - 9.9e-69 232.4 0.0 1.1e-68 232.2 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein Ribosomal_L2_C PF03947.18 EDP43272.1 - 3.6e-46 156.5 3.1 5.5e-46 155.9 3.1 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EDP43272.1 - 2e-14 53.3 0.0 5.1e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain EXS PF03124.14 EDP43273.1 - 4.2e-73 246.5 19.5 5.2e-73 246.2 19.5 1.0 1 0 0 1 1 1 1 EXS family SDA1 PF05285.12 EDP43274.1 - 3.5e-92 309.5 35.6 3.5e-92 309.5 35.6 2.1 2 0 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 EDP43274.1 - 8e-20 70.9 2.0 1.6e-19 70.0 0.1 2.4 2 0 0 2 2 2 1 NUC130/3NT domain DUF4042 PF13251.6 EDP43274.1 - 2 8.1 5.3 0.46 10.2 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) DEAD PF00270.29 EDP43275.1 - 3.5e-39 134.4 0.0 5.4e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EDP43275.1 - 2.4e-19 69.3 0.5 4.6e-19 68.4 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EDP43275.1 - 6.5e-19 68.3 0.0 1.6e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43275.1 - 7.2e-08 32.6 0.0 2.5e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDP43275.1 - 0.12 12.6 0.1 1.1 9.5 0.1 2.5 1 1 0 1 1 1 0 AAA domain RRM_3 PF08777.11 EDP43276.1 - 0.0044 17.1 0.0 0.0061 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA binding motif FoP_duplication PF13865.6 EDP43276.1 - 0.75 10.4 15.6 1.3 9.6 15.6 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 La PF05383.17 EDP43277.1 - 1.9e-24 85.5 0.0 3.6e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EDP43277.1 - 1.9e-07 30.8 0.6 4e-07 29.8 0.6 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRO8NT PF08082.11 EDP43277.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain VTC PF09359.10 EDP43278.1 - 1.6e-100 336.0 0.1 3.5e-100 334.9 0.1 1.6 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EDP43278.1 - 1.5e-16 61.4 4.6 1.5e-16 61.4 4.6 2.8 2 1 0 2 2 2 1 SPX domain DUF202 PF02656.15 EDP43278.1 - 1.5e-12 47.7 3.8 1.5e-12 47.7 3.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Herpes_UL25 PF01499.16 EDP43278.1 - 0.0077 14.8 2.2 0.013 14.0 2.2 1.3 1 0 0 1 1 1 1 Herpesvirus UL25 family DUF1319 PF07028.11 EDP43278.1 - 0.074 13.3 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) DUF4618 PF15397.6 EDP43278.1 - 4.9 6.5 6.1 5.4 6.4 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) COX15-CtaA PF02628.15 EDP43279.1 - 7.9e-95 317.6 3.8 1.1e-94 317.1 3.8 1.2 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Ni_hydr_CYTB PF01292.20 EDP43279.1 - 4 7.0 14.0 4.2e+03 -2.8 13.7 3.5 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 SH3_1 PF00018.28 EDP43280.1 - 3.3e-12 45.8 0.0 4.7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP43280.1 - 8.3e-11 41.6 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP43280.1 - 3.4e-06 26.7 0.0 5.7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.6 EDP43280.1 - 0.017 15.5 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain HLH PF00010.26 EDP43281.1 - 2.9e-13 49.6 0.1 5.4e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AAA PF00004.29 EDP43282.1 - 4.6e-06 27.1 0.0 1e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDP43282.1 - 0.0052 17.1 1.4 0.027 14.7 0.2 2.5 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EDP43282.1 - 0.0072 15.4 0.1 0.085 11.9 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein Rad17 PF03215.15 EDP43282.1 - 0.015 15.2 0.0 0.064 13.2 0.0 2.1 2 1 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 EDP43282.1 - 0.036 14.5 3.1 0.13 12.7 1.2 2.8 2 1 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 EDP43282.1 - 0.045 13.5 0.1 0.12 12.1 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 EDP43282.1 - 0.2 11.5 0.1 0.52 10.2 0.1 1.6 1 1 1 2 2 2 0 NTPase Peptidase_C25_C PF03785.14 EDP43283.1 - 0.023 14.5 2.8 0.067 13.0 2.8 1.7 1 0 0 1 1 1 0 Peptidase family C25, C terminal ig-like domain DSPn PF14671.6 EDP43284.1 - 5.8e-37 127.3 0.0 4e-36 124.6 0.0 2.0 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EDP43284.1 - 3.1e-13 49.7 0.0 1.1e-12 47.8 0.0 1.9 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDP43284.1 - 0.0015 18.1 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase EMG1 PF03587.14 EDP43285.1 - 2.1e-78 262.4 0.0 4e-78 261.6 0.0 1.4 2 0 0 2 2 2 1 EMG1/NEP1 methyltransferase Ank_2 PF12796.7 EDP43286.1 - 9.4e-20 71.0 0.1 3.7e-10 40.2 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP43286.1 - 6.1e-19 68.1 1.6 4.4e-11 43.1 0.3 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EDP43286.1 - 5e-16 58.3 0.2 7.7e-05 23.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EDP43286.1 - 7.8e-13 48.4 1.4 5.8e-05 23.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP43286.1 - 1.1e-12 46.9 0.9 0.002 18.4 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeat KilA-N PF04383.13 EDP43286.1 - 5.7e-06 26.1 0.1 3.4e-05 23.7 0.1 2.1 1 1 0 1 1 1 1 KilA-N domain UPF0300 PF08594.10 EDP43286.1 - 0.058 12.7 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0300) CLP1_P PF16575.5 EDP43287.1 - 1.1e-29 103.6 0.0 2.6e-28 99.1 0.0 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EDP43287.1 - 0.098 13.0 0.0 0.24 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Mito_carr PF00153.27 EDP43288.1 - 4.1e-63 209.3 2.2 1.1e-23 83.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein PMT PF02366.18 EDP43289.1 - 6.1e-83 278.2 15.3 1e-82 277.4 15.3 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EDP43289.1 - 3.2e-58 196.6 10.0 3.2e-58 196.6 10.0 2.0 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EDP43289.1 - 1.2e-25 90.4 0.0 2.5e-25 89.4 0.0 1.5 1 0 0 1 1 1 1 MIR domain 5-FTHF_cyc-lig PF01812.20 EDP43290.1 - 4.1e-32 111.6 0.0 5.2e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family DASH_Duo1 PF08651.10 EDP43291.1 - 0.087 12.6 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 DASH complex subunit Duo1 ACBP PF00887.19 EDP43292.1 - 5e-06 26.6 0.0 5.7e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Peroxin-3 PF04882.12 EDP43293.1 - 2e-120 403.0 0.2 1.3e-119 400.3 0.2 1.9 1 1 0 1 1 1 1 Peroxin-3 ABC_tran PF00005.27 EDP43294.1 - 1.9e-45 154.7 0.0 2.2e-25 89.8 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDP43294.1 - 5.2e-17 62.6 1.5 0.0081 16.0 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDP43294.1 - 1.7e-10 40.8 0.0 0.00038 19.9 0.0 3.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 EDP43294.1 - 1.2e-09 37.9 0.2 2.5e-09 36.9 0.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 EDP43294.1 - 7.6e-07 29.8 0.9 0.038 14.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EDP43294.1 - 2.8e-06 27.4 0.2 0.0052 16.8 0.0 3.7 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EDP43294.1 - 3.2e-06 26.8 0.1 0.045 13.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain HEAT_EZ PF13513.6 EDP43294.1 - 2.4e-05 24.7 2.0 0.64 10.6 0.1 5.0 4 0 0 4 4 4 1 HEAT-like repeat DUF87 PF01935.17 EDP43294.1 - 8.1e-05 22.8 0.3 0.097 12.8 0.0 3.0 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_22 PF13401.6 EDP43294.1 - 0.00012 22.4 0.1 0.7 10.2 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EDP43294.1 - 0.00018 21.9 1.7 0.25 11.7 0.0 4.6 4 1 1 5 5 5 1 AAA ATPase domain AAA_30 PF13604.6 EDP43294.1 - 0.0014 18.3 1.0 0.3 10.8 0.0 3.3 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EDP43294.1 - 0.0019 18.1 0.0 0.064 13.2 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 EDP43294.1 - 0.0019 17.2 0.2 0.15 11.0 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDP43294.1 - 0.015 15.2 0.0 4.2 7.3 0.0 2.7 2 0 0 2 2 2 0 NACHT domain SR-25 PF10500.9 EDP43294.1 - 0.016 14.9 2.8 0.032 13.8 2.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_27 PF13514.6 EDP43294.1 - 0.019 14.6 0.1 7.3 6.1 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 EDP43294.1 - 0.019 14.7 0.0 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EDP43294.1 - 0.022 14.1 0.2 12 5.1 0.0 3.5 3 0 0 3 3 3 0 Zeta toxin AAA_24 PF13479.6 EDP43294.1 - 0.024 14.3 0.0 6.1 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EDP43294.1 - 0.025 14.8 1.2 5.1 7.3 0.0 3.3 4 0 0 4 4 2 0 AAA domain cobW PF02492.19 EDP43294.1 - 0.033 13.8 0.1 6.2 6.4 0.0 3.3 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EDP43294.1 - 0.034 14.7 0.0 2.7 8.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain HEAT_2 PF13646.6 EDP43294.1 - 0.05 14.0 13.0 2.2 8.7 2.6 4.5 3 2 1 4 4 4 0 HEAT repeats Tudor-knot PF11717.8 EDP43294.1 - 0.054 13.4 0.1 0.16 11.9 0.1 1.8 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain AAA_33 PF13671.6 EDP43294.1 - 0.06 13.5 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDP43294.1 - 0.071 13.5 0.0 2 8.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 EDP43294.1 - 0.12 11.8 0.5 0.57 9.7 0.0 2.2 3 0 0 3 3 3 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EDP43294.1 - 0.13 12.3 0.0 0.96 9.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family DUF2600 PF10776.9 EDP43294.1 - 0.14 11.0 0.1 0.32 9.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) WD40 PF00400.32 EDP43295.1 - 1.2e-05 26.0 4.6 0.15 13.0 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_2 PF13360.6 EDP43295.1 - 0.039 13.5 0.1 0.073 12.6 0.1 1.4 1 0 0 1 1 1 0 PQQ-like domain MMS1_N PF10433.9 EDP43295.1 - 0.16 10.6 0.0 15 4.0 0.0 2.9 2 1 1 3 3 3 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term DnaJ PF00226.31 EDP43296.1 - 2e-16 59.8 0.2 4.5e-16 58.7 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain NOA36 PF06524.12 EDP43296.1 - 0.31 10.3 25.6 0.66 9.2 25.6 1.5 1 0 0 1 1 1 0 NOA36 protein SAPS PF04499.15 EDP43296.1 - 1.1 8.0 4.3 1.5 7.5 4.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cwf_Cwc_15 PF04889.12 EDP43296.1 - 5.6 6.6 29.1 13 5.5 29.1 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFB6 PF17110.5 EDP43296.1 - 7.8 6.2 10.3 18 5.1 10.3 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Fumble PF03630.14 EDP43297.1 - 1.6e-120 402.2 0.0 2.4e-120 401.7 0.0 1.2 1 0 0 1 1 1 1 Fumble UPF0184 PF03670.13 EDP43297.1 - 0.14 12.5 0.1 0.49 10.8 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Spt4 PF06093.13 EDP43298.1 - 2.6e-30 104.4 0.3 2.9e-30 104.2 0.3 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger MIF4G_like PF09088.11 EDP43299.1 - 7.2e-63 211.8 0.0 1.7e-62 210.6 0.0 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EDP43299.1 - 7.7e-63 212.5 2.2 1.6e-62 211.4 2.2 1.5 1 0 0 1 1 1 1 MIF4G like Alanine_zipper PF11839.8 EDP43299.1 - 0.19 12.1 3.4 0.26 11.7 1.8 2.1 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Eaf7 PF07904.13 EDP43300.1 - 0.017 15.5 0.1 0.017 15.5 0.1 2.0 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Mitofilin PF09731.9 EDP43300.1 - 0.93 8.3 10.2 1.1 8.1 10.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Glyco_transf_15 PF01793.16 EDP43301.1 - 3.9e-114 381.3 7.7 4.9e-114 380.9 7.7 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Glyco_transf_15 PF01793.16 EDP43302.1 - 1.4e-92 310.4 6.7 1.6e-92 310.2 6.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase RNA_pol_A_bac PF01000.26 EDP43303.1 - 6.2e-28 97.4 0.0 1.1e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDP43303.1 - 0.00034 20.0 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LIM_bind PF01803.16 EDP43304.1 - 2.5e-17 63.2 0.0 3.4e-16 59.5 0.0 2.0 1 1 0 1 1 1 1 LIM-domain binding protein DUF2456 PF10445.9 EDP43305.1 - 4.3e-20 71.6 7.6 1.8e-19 69.6 5.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF2456) URO-D PF01208.17 EDP43306.1 - 3.3e-111 371.8 0.0 3.7e-111 371.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) TIP49 PF06068.13 EDP43307.1 - 7e-159 528.7 0.0 9.6e-159 528.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDP43307.1 - 3.1e-21 75.3 0.1 7.5e-21 74.0 0.1 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EDP43307.1 - 6.3e-09 36.4 1.4 2.2e-05 24.9 0.1 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDP43307.1 - 2e-08 34.1 0.1 5.4e-05 23.0 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDP43307.1 - 3.6e-07 30.5 0.1 0.0078 16.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EDP43307.1 - 0.00026 21.0 0.1 0.1 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EDP43307.1 - 0.00039 20.8 3.2 0.12 12.7 0.1 2.9 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EDP43307.1 - 0.00084 19.8 0.9 0.015 15.7 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EDP43307.1 - 0.0014 18.2 1.0 0.0053 16.3 0.3 2.1 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 EDP43307.1 - 0.0059 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EDP43307.1 - 0.0076 15.6 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 EDP43307.1 - 0.013 15.2 0.1 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EDP43307.1 - 0.019 14.3 0.1 1.2 8.4 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EDP43307.1 - 0.029 14.1 0.1 0.092 12.5 0.1 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2075 PF09848.9 EDP43307.1 - 0.059 12.6 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EDP43307.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CENP-S PF15630.6 EDP43307.1 - 0.067 13.6 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 CENP-S protein Zeta_toxin PF06414.12 EDP43307.1 - 0.1 11.9 0.2 0.25 10.6 0.2 1.6 1 0 0 1 1 1 0 Zeta toxin IMPDH PF00478.25 EDP43308.1 - 4.6e-134 446.8 0.0 4.2e-132 440.3 0.0 2.0 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EDP43308.1 - 6.1e-14 52.2 0.4 1.3e-05 25.5 0.0 3.0 3 0 0 3 3 3 2 CBS domain FMN_dh PF01070.18 EDP43308.1 - 3.1e-13 49.5 0.3 1.3e-12 47.5 0.4 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EDP43308.1 - 2.3e-11 43.7 3.0 3.8e-09 36.4 1.9 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 EDP43308.1 - 2.9e-08 33.4 1.8 1.2e-05 24.9 0.3 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.14 EDP43308.1 - 0.00079 18.8 2.8 0.0016 17.8 1.0 2.0 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 EDP43308.1 - 0.0017 17.6 0.1 0.0039 16.4 0.1 1.5 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Glu_synthase PF01645.17 EDP43308.1 - 0.013 14.6 1.8 0.023 13.9 1.8 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase PK PF00224.21 EDP43308.1 - 0.013 14.4 0.0 0.03 13.2 0.0 1.5 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain G3P_antiterm PF04309.12 EDP43308.1 - 0.013 14.9 0.6 0.79 9.1 0.1 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator EAL PF00563.20 EDP43308.1 - 0.016 14.8 0.8 3.6 7.0 0.1 2.6 2 1 1 3 3 3 0 EAL domain Aldolase PF01081.19 EDP43308.1 - 0.019 14.4 0.3 0.063 12.7 0.1 2.0 2 0 0 2 2 2 0 KDPG and KHG aldolase Dus PF01207.17 EDP43308.1 - 0.047 12.8 2.1 0.64 9.1 0.2 2.2 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) YpsA PF06908.11 EDP43308.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family DHO_dh PF01180.21 EDP43308.1 - 0.27 10.4 2.8 0.69 9.1 0.3 2.3 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase TAF4 PF05236.14 EDP43309.1 - 3.2e-29 102.6 7.1 3.2e-29 102.6 7.1 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family EPL1 PF10513.9 EDP43309.1 - 0.8 10.1 18.1 0.22 11.9 2.8 2.5 2 1 0 2 2 2 0 Enhancer of polycomb-like Lin-8 PF03353.15 EDP43309.1 - 1.3 8.5 21.5 0.96 9.0 9.4 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF908 PF06012.12 EDP43309.1 - 6.5 6.1 22.4 1.7 8.0 1.9 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Glyco_transf_15 PF01793.16 EDP43310.1 - 8.4e-107 357.2 14.8 2.1e-106 355.9 14.8 1.5 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PPR_2 PF13041.6 EDP43311.1 - 6.9e-36 122.2 0.0 5.2e-11 42.6 0.0 10.2 8 2 3 11 11 11 5 PPR repeat family PPR PF01535.20 EDP43311.1 - 6.5e-27 91.9 2.7 0.0018 18.4 0.0 12.6 12 2 0 12 12 12 4 PPR repeat PPR_3 PF13812.6 EDP43311.1 - 3.4e-20 71.9 0.0 3e-07 30.4 0.0 6.9 6 1 3 9 9 9 5 Pentatricopeptide repeat domain PPR_long PF17177.4 EDP43311.1 - 3.7e-17 62.4 4.7 1.3e-12 47.6 0.1 4.7 5 0 0 5 5 5 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EDP43311.1 - 4.3e-15 55.1 0.0 1.9e-05 24.3 0.0 7.0 9 0 0 9 9 9 3 PPR repeat ECSIT PF06239.11 EDP43311.1 - 0.12 11.4 0.0 13 4.8 0.0 2.5 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway RRM_1 PF00076.22 EDP43312.1 - 0.0019 18.0 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nucleo_P87 PF07267.11 EDP43312.1 - 0.016 14.1 0.3 0.019 13.9 0.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Kinesin PF00225.23 EDP43313.1 - 6.7e-89 298.1 0.1 9.1e-89 297.7 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDP43313.1 - 1.5e-13 50.9 0.0 1e-09 38.5 0.0 2.6 2 0 0 2 2 2 2 Microtubule binding AMP_N PF05195.16 EDP43314.1 - 1.8e-39 134.2 0.0 2.8e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Peptidase_M24 PF00557.24 EDP43314.1 - 0.013 15.2 0.1 0.028 14.1 0.1 1.5 1 0 0 1 1 1 0 Metallopeptidase family M24 Peptidase_M24 PF00557.24 EDP43315.1 - 8.3e-31 107.3 0.0 1e-30 107.0 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 S4 PF01479.25 EDP43316.1 - 2.5e-11 43.1 0.0 6e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EDP43316.1 - 7.4e-10 39.6 0.8 1.1e-09 39.0 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Fe_hyd_lg_C PF02906.14 EDP43317.1 - 2.4e-62 210.7 0.0 3.7e-62 210.2 0.0 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain OmpH PF03938.14 EDP43318.1 - 0.067 13.5 5.1 0.11 12.9 5.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 EDP43318.1 - 0.21 10.8 2.9 0.29 10.4 2.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin_2 PF14523.6 EDP43318.1 - 0.65 10.4 6.2 0.89 10.0 5.2 1.7 1 1 1 2 2 2 0 Syntaxin-like protein S36_mt PF10937.8 EDP43319.1 - 1.2e-11 46.2 1.4 2.4e-11 45.2 1.4 1.5 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial NDUF_B7 PF05676.13 EDP43320.1 - 8.7e-19 67.0 0.2 1.1e-18 66.7 0.2 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 EDP43320.1 - 0.024 14.7 0.3 0.034 14.2 0.3 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like XRN_M PF17846.1 EDP43322.1 - 9.3e-153 509.3 1.8 6.9e-112 374.6 0.4 2.4 2 1 0 2 2 2 2 Xrn1 helical domain XRN_N PF03159.18 EDP43322.1 - 8.1e-91 303.7 0.0 8.1e-91 303.7 0.0 2.6 5 0 0 5 5 5 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 EDP43322.1 - 0.0011 18.9 5.7 0.0022 18.0 5.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 EDP43322.1 - 0.25 11.4 4.1 0.25 11.3 2.0 2.2 2 0 0 2 2 2 0 Zinc knuckle PMI_typeI PF01238.21 EDP43323.1 - 5.3e-14 52.2 0.0 6.4e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I PMI_typeI PF01238.21 EDP43324.1 - 1.9e-73 247.8 0.0 2.2e-73 247.6 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 EDP43324.1 - 3.4e-07 29.9 0.0 0.00013 21.6 0.0 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EDP43324.1 - 1.2e-06 28.4 0.0 0.00022 21.2 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain PPR_2 PF13041.6 EDP43325.1 - 0.0003 20.9 0.0 0.00083 19.5 0.0 1.7 1 0 0 1 1 1 1 PPR repeat family Abhydrolase_3 PF07859.13 EDP43326.1 - 1.5e-27 96.9 0.0 1.9e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EDP43326.1 - 1.4e-05 24.6 0.0 0.001 18.6 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 EDP43326.1 - 6.1e-05 22.7 0.0 0.011 15.3 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EDP43326.1 - 0.0014 18.3 0.1 0.0034 17.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EDP43326.1 - 0.0015 18.5 0.0 0.0048 16.9 0.0 1.7 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EDP43326.1 - 0.0019 17.9 0.0 0.0043 16.7 0.0 1.5 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase_phd PF10503.9 EDP43326.1 - 0.012 15.1 0.0 0.031 13.8 0.0 1.6 2 0 0 2 2 2 0 Esterase PHB depolymerase AXE1 PF05448.12 EDP43326.1 - 0.04 12.6 0.0 0.066 11.9 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EDP43327.1 - 7.3e-34 117.5 0.0 9.5e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 EDP43327.1 - 0.093 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) LIDHydrolase PF10230.9 EDP43327.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Acetyltransf_1 PF00583.25 EDP43328.1 - 1.5e-18 67.1 0.1 2.1e-18 66.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDP43328.1 - 6.3e-11 42.3 0.0 8.7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDP43328.1 - 6.4e-10 39.3 0.0 9.1e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDP43328.1 - 2.9e-09 36.7 0.1 4.4e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EDP43328.1 - 1.8e-07 31.3 0.1 2.6e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EDP43328.1 - 5e-05 23.0 0.0 8.3e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EDP43328.1 - 0.00014 21.9 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EDP43328.1 - 0.00026 21.7 0.1 0.00034 21.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4748 PF15932.5 EDP43329.1 - 0.063 13.0 0.0 0.082 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) CwfJ_C_1 PF04677.15 EDP43330.1 - 2e-29 102.0 0.0 3.3e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Cnd1 PF12717.7 EDP43331.1 - 6.6e-51 172.6 6.8 2.8e-48 164.0 0.0 3.7 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 EDP43331.1 - 3e-36 124.8 0.1 1e-35 123.1 0.0 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 EDP43331.1 - 2.8e-07 30.2 5.3 1.1 9.7 0.1 6.6 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 EDP43331.1 - 5.8e-06 26.6 2.4 0.25 11.8 0.1 4.6 3 1 0 3 3 3 2 HEAT repeats Cnd3 PF12719.7 EDP43331.1 - 0.00016 21.0 0.6 0.0048 16.1 0.4 2.7 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.20 EDP43331.1 - 0.00057 18.6 1.6 0.015 13.9 0.0 2.8 3 0 0 3 3 3 1 Adaptin N terminal region ELMO_CED12 PF04727.13 EDP43331.1 - 0.076 13.1 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 ELMO/CED-12 family HEAT_EZ PF13513.6 EDP43331.1 - 0.17 12.5 9.6 0.65 10.6 0.2 4.8 5 0 0 5 5 4 0 HEAT-like repeat RTP1_C1 PF10363.9 EDP43331.1 - 0.56 10.4 8.4 4.4 7.5 0.0 5.0 6 1 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 PqqD PF05402.12 EDP43331.1 - 0.59 10.5 2.3 21 5.5 0.0 4.0 4 0 0 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) Arm PF00514.23 EDP43331.1 - 0.67 10.1 2.5 7.3 6.8 0.1 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Sec62 PF03839.16 EDP43332.1 - 2.6e-52 177.5 3.8 4.5e-52 176.7 3.8 1.4 1 1 0 1 1 1 1 Translocation protein Sec62 Alg6_Alg8 PF03155.15 EDP43333.1 - 5e-120 401.7 23.8 8.9e-92 308.6 16.2 2.2 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family Actin PF00022.19 EDP43334.1 - 4e-122 407.7 0.0 1.7e-121 405.7 0.0 1.7 1 1 0 1 1 1 1 Actin Pkinase PF00069.25 EDP43335.1 - 1e-56 192.2 0.0 1.4e-55 188.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43335.1 - 9.3e-27 93.9 0.0 1.7e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3027 PF11228.8 EDP43335.1 - 0.029 14.4 0.4 0.053 13.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) UCH PF00443.29 EDP43336.1 - 6.1e-48 163.6 0.1 7.9e-48 163.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP43336.1 - 7.8e-30 104.6 3.1 1.1e-28 100.7 3.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDP43336.1 - 0.0046 16.5 0.4 0.057 12.9 1.0 2.1 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DPBB_1 PF03330.18 EDP43337.1 - 5.9e-07 29.7 0.1 1.1e-06 28.9 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EDP43337.1 - 1.3e-05 25.0 0.2 2e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 Barwin family DUF4889 PF16230.5 EDP43337.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) TIM21 PF08294.11 EDP43338.1 - 1.3e-13 51.0 0.0 1.7e-11 44.2 0.0 2.6 2 1 0 2 2 2 2 TIM21 RL10P_insert PF17777.1 EDP43339.1 - 7e-23 80.4 0.0 1.1e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EDP43339.1 - 2.2e-18 66.2 0.0 3.4e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 HEAT_2 PF13646.6 EDP43340.1 - 1e-26 93.1 4.2 1.5e-14 54.1 0.0 3.2 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 EDP43340.1 - 2.1e-12 46.5 0.3 0.00096 19.6 0.0 6.6 7 1 0 7 7 7 3 PBS lyase HEAT-like repeat HEAT PF02985.22 EDP43340.1 - 6.8e-10 38.4 1.4 0.3 11.5 0.0 6.0 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 EDP43340.1 - 2.2e-06 28.0 1.9 0.13 12.8 0.1 4.2 3 1 1 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 EDP43340.1 - 6.6e-05 23.0 0.1 1.1 9.3 0.0 3.3 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 UPF0147 PF03685.13 EDP43340.1 - 0.018 15.1 0.4 0.91 9.6 0.0 3.6 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0147) Arm PF00514.23 EDP43340.1 - 0.021 14.9 0.0 18 5.5 0.0 3.6 2 1 1 3 3 3 0 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.7 EDP43340.1 - 0.26 11.7 2.0 19 5.7 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Ligase_CoA PF00549.19 EDP43341.1 - 5.1e-22 78.3 0.0 6.4e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EDP43341.1 - 1.4e-07 31.4 0.0 2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain Vta1 PF04652.16 EDP43342.1 - 8.2e-31 106.9 0.1 9e-31 106.8 0.1 1.0 1 0 0 1 1 1 1 Vta1 like DWNN PF08783.11 EDP43343.1 - 1.2e-32 112.0 0.0 1.9e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EDP43343.1 - 9.2e-10 38.2 6.2 1.8e-09 37.2 6.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EDP43343.1 - 2.7e-06 27.2 1.4 4.8e-06 26.4 1.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 EDP43343.1 - 0.00021 21.1 11.0 0.00021 21.1 11.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.6 EDP43343.1 - 0.0021 18.0 0.2 0.0057 16.6 0.2 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EDP43343.1 - 0.0042 16.9 14.8 0.0042 16.9 14.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP43343.1 - 0.018 15.4 14.1 0.018 15.4 14.1 1.7 2 0 0 2 2 1 0 Ring finger domain zf-RING_5 PF14634.6 EDP43343.1 - 0.019 15.0 14.2 0.019 15.0 14.2 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EDP43343.1 - 0.02 14.8 14.8 0.038 13.9 14.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ArenaCapSnatch PF17296.2 EDP43343.1 - 0.029 13.8 0.2 0.05 13.0 0.2 1.3 1 0 0 1 1 1 0 Arenavirus cap snatching domain zf_C2H2_10 PF18414.1 EDP43343.1 - 0.033 13.7 0.5 0.033 13.7 0.5 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger zf-CCHC_5 PF14787.6 EDP43343.1 - 0.061 13.0 4.3 0.09 12.5 0.7 2.9 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Siva PF05458.12 EDP43343.1 - 0.062 13.0 3.2 0.14 11.9 3.2 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-C3HC4_4 PF15227.6 EDP43343.1 - 0.77 10.0 14.0 1.6 8.9 14.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Sec8_exocyst PF04048.14 EDP43345.1 - 3.9e-28 98.1 0.0 7.3e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain COG2 PF06148.11 EDP43345.1 - 6.1e-06 26.4 2.1 4.5e-05 23.6 0.0 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.9 EDP43345.1 - 1.4e-05 24.5 0.1 2.8e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Ribosomal_S5 PF00333.20 EDP43346.1 - 1.6e-17 63.2 0.5 2.8e-17 62.4 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDP43346.1 - 5e-16 57.9 0.0 1.5e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain RRM_1 PF00076.22 EDP43347.1 - 7.6e-32 109.0 0.0 6.5e-18 64.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3932 PF13068.6 EDP43347.1 - 0.099 12.9 0.0 21 5.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3932) Methyltransf_16 PF10294.9 EDP43349.1 - 8.6e-17 61.4 0.0 1.1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EDP43349.1 - 0.0017 17.8 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EDP43349.1 - 0.01 15.7 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Hap4_Hap_bind PF10297.9 EDP43350.1 - 6.7e-07 29.2 4.0 1.5e-06 28.1 4.0 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EDP43350.1 - 4e-06 26.8 13.7 2.3e-05 24.4 10.7 2.2 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EDP43350.1 - 0.0037 17.3 13.7 0.058 13.5 2.8 2.3 2 0 0 2 2 2 2 Basic region leucine zipper TolA_bind_tri PF16331.5 EDP43350.1 - 0.43 10.7 5.7 0.78 9.9 5.7 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation HAUS6_N PF14661.6 EDP43350.1 - 2.3 7.7 5.9 3.7 7.1 5.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus RibD_C PF01872.17 EDP43351.1 - 3e-30 105.6 0.0 3.4e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain MASE2 PF05230.11 EDP43351.1 - 0.084 12.9 0.5 0.51 10.4 0.1 2.1 2 0 0 2 2 2 0 MASE2 domain GSCFA PF08885.11 EDP43351.1 - 0.19 11.3 0.1 0.31 10.7 0.1 1.4 1 1 0 1 1 1 0 GSCFA family CX9C PF16860.5 EDP43352.1 - 3.2e-18 65.5 11.6 9.4e-14 51.2 3.6 2.3 2 1 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EDP43352.1 - 1e-05 25.5 6.6 0.035 14.2 1.8 2.9 2 2 1 3 3 3 3 CHCH domain Cmc1 PF08583.10 EDP43352.1 - 0.0014 18.6 11.0 1.2 9.2 2.2 3.8 1 1 2 3 3 3 3 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EDP43352.1 - 0.024 14.9 8.6 0.25 11.6 1.0 2.7 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein GCK PF07802.11 EDP43352.1 - 0.074 13.5 5.3 3.2 8.3 0.7 2.8 1 1 3 4 4 4 0 GCK domain Pet191_N PF10203.9 EDP43352.1 - 0.11 12.8 10.9 2 8.8 6.4 2.9 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 EDP43352.1 - 0.51 10.1 9.8 1.3 8.8 1.0 2.8 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX17 PF05051.13 EDP43352.1 - 0.8 10.1 8.6 1.3 9.4 0.8 3.1 1 1 3 4 4 4 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 EDP43352.1 - 1.1 9.6 6.5 1.7 9.0 0.2 2.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) zf-C3Hc3H PF13891.6 EDP43352.1 - 1.5 9.3 8.0 1.6 9.1 2.6 2.9 1 1 1 2 2 2 0 Potential DNA-binding domain zinc-ribbons_6 PF07191.12 EDP43352.1 - 5.2 7.1 13.0 27 4.8 0.2 3.0 1 1 2 3 3 3 0 zinc-ribbons MTCP1 PF08991.10 EDP43352.1 - 8 6.8 12.3 7.4 6.9 3.1 2.8 2 1 1 3 3 3 0 Mature-T-Cell Proliferation I type TIM PF00121.18 EDP43353.1 - 4.2e-51 173.7 0.0 5e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Cyclin_N PF00134.23 EDP43354.1 - 1.9e-10 40.6 4.0 4.5e-10 39.4 2.0 2.3 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDP43354.1 - 0.05 13.7 1.8 0.36 10.9 0.3 2.4 2 0 0 2 2 2 0 Cyclin, C-terminal domain Spy1 PF11357.8 EDP43354.1 - 0.071 13.4 0.2 0.69 10.2 0.1 2.3 2 0 0 2 2 2 0 Cell cycle regulatory protein TFIIB PF00382.19 EDP43354.1 - 0.14 12.2 0.4 0.89 9.6 0.1 2.3 2 0 0 2 2 2 0 Transcription factor TFIIB repeat DRMBL PF07522.14 EDP43355.1 - 1.5e-25 89.5 0.0 2.7e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EDP43355.1 - 9.8e-07 28.5 0.1 2.2e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDP43355.1 - 0.022 14.8 0.1 0.05 13.6 0.1 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lyase_1 PF00206.20 EDP43356.1 - 9.8e-23 81.0 0.0 1.5e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EDP43356.1 - 6.6e-19 68.2 0.0 1.9e-18 66.7 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus SelR PF01641.18 EDP43357.1 - 3.1e-52 175.7 0.1 3.5e-52 175.6 0.1 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EDP43357.1 - 0.0011 18.6 0.1 0.26 11.0 0.0 2.2 2 0 0 2 2 2 2 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 EDP43357.1 - 0.01 16.1 0.3 0.027 14.7 0.3 1.7 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 EDP43357.1 - 0.077 13.0 2.3 4.2 7.5 0.1 2.3 2 1 0 2 2 2 0 Double zinc ribbon zf-Mss51 PF13824.6 EDP43357.1 - 0.22 11.6 2.0 7.4 6.7 0.4 2.9 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 DNA_RNApol_7kD PF03604.13 EDP43357.1 - 0.25 11.1 3.0 5.8 6.7 0.1 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit DUF1604 PF07713.13 EDP43358.1 - 4.8e-07 29.5 1.1 2e-06 27.5 1.1 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EDP43358.1 - 4.6e-05 23.2 1.2 9.1e-05 22.3 1.2 1.5 1 0 0 1 1 1 1 G-patch domain BUD22 PF09073.10 EDP43358.1 - 0.014 14.7 8.9 0.01 15.2 2.2 2.4 2 0 0 2 2 2 0 BUD22 G-patch_2 PF12656.7 EDP43358.1 - 0.15 12.1 0.1 0.5 10.5 0.1 1.8 1 0 0 1 1 1 0 G-patch domain TP_methylase PF00590.20 EDP43359.1 - 7.9e-06 26.0 1.3 3.8e-05 23.7 0.1 2.3 1 1 1 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF1899 PF08953.11 EDP43360.1 - 2.9e-22 78.3 0.0 6.5e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EDP43360.1 - 2e-17 62.8 1.6 8.1e-16 57.6 0.6 2.6 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 EDP43360.1 - 2.2e-10 40.9 2.1 0.04 14.8 0.3 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43360.1 - 0.00013 22.2 0.0 0.46 10.8 0.0 4.2 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 EDP43360.1 - 0.0054 15.8 0.0 0.016 14.3 0.0 1.7 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain ZapB PF06005.12 EDP43360.1 - 0.0056 17.1 1.9 0.013 16.0 1.9 1.5 1 0 0 1 1 1 1 Cell division protein ZapB Blt1 PF12754.7 EDP43360.1 - 0.016 15.5 0.7 0.034 14.5 0.7 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain YabA PF06156.13 EDP43360.1 - 0.052 14.2 0.9 0.13 12.9 0.9 1.6 1 0 0 1 1 1 0 Initiation control protein YabA TSC22 PF01166.18 EDP43360.1 - 0.24 11.7 1.0 0.87 10.0 1.0 1.8 1 1 0 1 1 1 0 TSC-22/dip/bun family Nop25 PF09805.9 EDP43361.1 - 1.6e-16 61.0 14.1 1.6e-16 61.0 14.1 2.9 3 0 0 3 3 3 1 Nucleolar protein 12 (25kDa) MAT1 PF06391.13 EDP43362.1 - 3.4e-42 144.6 28.7 4.3e-42 144.3 28.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EDP43362.1 - 1.5e-21 76.0 6.8 7.3e-21 73.8 5.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP43362.1 - 6.1e-06 26.0 6.4 1.6e-05 24.7 6.5 1.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP43362.1 - 1.8e-05 24.6 6.0 0.00011 22.1 6.6 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDP43362.1 - 1.8e-05 24.5 5.2 4.4e-05 23.3 5.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP43362.1 - 2e-05 24.8 5.9 3.3e-05 24.1 5.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP43362.1 - 8.8e-05 22.3 8.0 0.00023 20.9 8.1 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EDP43362.1 - 0.0056 16.4 4.5 0.04 13.7 1.5 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EDP43362.1 - 0.0056 16.5 9.7 0.33 10.9 9.5 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EDP43362.1 - 0.0063 16.5 6.0 0.013 15.5 6.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger FYDLN_acid PF09538.10 EDP43362.1 - 0.084 13.6 0.1 0.084 13.6 0.1 3.0 2 1 0 2 2 1 0 Protein of unknown function (FYDLN_acid) zf-ribbon_3 PF13248.6 EDP43362.1 - 0.087 12.3 3.8 1.1 8.8 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 EDP43362.1 - 0.089 12.8 3.6 0.22 11.5 3.6 1.7 1 1 0 1 1 1 0 Double zinc ribbon DNA_ligase_ZBD PF03119.16 EDP43362.1 - 0.12 12.4 1.4 1.5 8.9 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain TF_Zn_Ribbon PF08271.12 EDP43362.1 - 0.21 11.1 1.5 20 4.8 0.2 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding zf-UDP PF14569.6 EDP43362.1 - 0.44 10.7 4.6 5.6 7.2 4.4 2.2 1 1 1 2 2 2 0 Zinc-binding RING-finger TFIIA PF03153.13 EDP43362.1 - 0.68 9.9 13.5 0.87 9.5 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zn-ribbon_8 PF09723.10 EDP43362.1 - 0.8 9.9 6.6 3.2 7.9 3.6 2.7 2 0 0 2 2 2 0 Zinc ribbon domain YhfH PF14149.6 EDP43362.1 - 0.8 9.7 5.0 4.4 7.4 0.1 2.5 2 0 0 2 2 2 0 YhfH-like protein zf-C3HC4_4 PF15227.6 EDP43362.1 - 0.86 9.8 7.1 2.6 8.3 7.1 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF4662 PF15578.6 EDP43362.1 - 3.2 7.5 8.3 5.9 6.6 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) UbiA PF01040.18 EDP43363.1 - 6.7e-55 186.1 19.4 9.4e-55 185.6 19.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3176 PF11374.8 EDP43363.1 - 0.0056 16.9 0.2 0.012 15.8 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) adh_short PF00106.25 EDP43364.1 - 2.4e-40 138.1 0.0 2.9e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP43364.1 - 1e-31 110.3 0.2 1.3e-31 110.0 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP43364.1 - 1.3e-10 41.4 0.1 1.9e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDP43364.1 - 0.0089 15.5 0.3 0.022 14.2 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EDP43364.1 - 0.035 13.9 0.1 0.066 13.0 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DASH_Dam1 PF08653.10 EDP43366.1 - 3e-20 71.8 0.1 4.3e-20 71.3 0.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 Acylphosphatase PF00708.18 EDP43367.1 - 9.8e-16 57.9 0.0 9.8e-16 57.9 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase Acyltransferase PF01553.21 EDP43368.1 - 1.1e-13 50.9 0.0 1.6e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase MIT PF04212.18 EDP43368.1 - 0.29 11.3 1.9 0.69 10.0 1.9 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain UvrD_C PF13361.6 EDP43369.1 - 1.6e-59 202.1 0.0 5e-59 200.4 0.0 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EDP43369.1 - 1.4e-57 195.7 0.0 2.9e-57 194.6 0.0 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EDP43369.1 - 1.2e-29 103.5 0.0 2.3e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EDP43369.1 - 4e-12 45.8 3.0 1.4e-11 44.0 0.6 3.0 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EDP43369.1 - 7e-08 32.5 0.7 0.028 14.2 0.0 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EDP43369.1 - 4.4e-05 23.3 0.0 0.0018 18.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EDP43369.1 - 0.09 12.4 0.0 4.2 6.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EDP43369.1 - 0.13 12.5 0.0 0.55 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mito_carr PF00153.27 EDP43370.1 - 6.5e-53 176.6 7.8 1.6e-19 69.6 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDP43370.1 - 0.0066 15.6 0.0 1.3 8.1 0.0 2.4 2 0 0 2 2 2 2 Gammaproteobacterial serine protease Tropomyosin_1 PF12718.7 EDP43371.1 - 0.00079 19.6 8.9 0.00079 19.6 8.9 2.8 1 1 2 3 3 3 1 Tropomyosin like DUF4250 PF14056.6 EDP43371.1 - 0.17 11.9 0.4 0.43 10.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) KASH_CCD PF14662.6 EDP43371.1 - 0.31 10.8 32.5 0.45 10.3 23.6 2.3 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH TFIIA PF03153.13 EDP43371.1 - 0.35 10.8 22.4 0.51 10.3 22.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fib_alpha PF08702.10 EDP43371.1 - 1.2 9.3 19.0 2.1 8.5 12.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4472 PF14739.6 EDP43371.1 - 4.6 8.0 36.5 1.6 9.5 13.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) Inv-AAD PF18785.1 EDP43372.1 - 1.3e-25 89.7 0.0 5e-22 78.2 0.1 2.5 2 0 0 2 2 2 2 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EDP43372.1 - 5.2e-09 35.9 0.5 4.6e-08 32.9 0.5 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PAP2 PF01569.21 EDP43372.1 - 3.6e-08 33.3 7.3 3.3e-07 30.1 7.3 2.2 1 1 0 1 1 1 1 PAP2 superfamily APOBEC_N PF08210.11 EDP43372.1 - 1.3e-05 25.2 0.5 2.4e-05 24.3 0.1 1.6 2 0 0 2 2 2 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 EDP43372.1 - 0.0025 17.9 0.1 0.017 15.2 0.0 2.2 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 EDP43372.1 - 0.012 15.7 0.1 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 APOBEC2 UPF0542 PF15086.6 EDP43372.1 - 0.13 12.2 0.0 0.47 10.4 0.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 NnrU PF07298.11 EDP43372.1 - 0.83 9.1 9.0 0.047 13.2 3.6 1.7 2 0 0 2 2 2 0 NnrU protein Rsm1 PF08600.10 EDP43373.1 - 0.059 13.5 1.7 1 9.6 0.1 2.6 2 0 0 2 2 2 0 Rsm1-like Peptidase_M20 PF01546.28 EDP43374.1 - 8.9e-32 110.5 0.0 1.3e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDP43374.1 - 2.1e-13 50.1 0.0 3.3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain HTH_WhiA PF02650.14 EDP43374.1 - 0.0096 16.2 0.1 0.14 12.5 0.0 2.5 3 0 0 3 3 3 1 WhiA C-terminal HTH domain Peptidase_M28 PF04389.17 EDP43374.1 - 0.017 14.9 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 TPK_catalytic PF04263.16 EDP43375.1 - 1.2e-26 93.1 0.0 1.5e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPR_11 PF13414.6 EDP43376.1 - 1.3e-17 63.1 3.8 2.6e-08 33.4 0.3 3.2 2 1 1 3 3 3 3 TPR repeat TPR_1 PF00515.28 EDP43376.1 - 1e-11 44.1 2.8 2.4e-05 24.0 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43376.1 - 1.6e-11 44.0 2.9 0.00073 20.2 0.2 3.5 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDP43376.1 - 1.8e-11 43.2 3.1 0.00036 20.4 0.1 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43376.1 - 2e-10 41.1 1.3 0.00031 21.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP43376.1 - 2.4e-09 36.9 2.6 0.013 15.9 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43376.1 - 6.4e-09 35.3 1.7 0.002 18.2 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43376.1 - 7.4e-08 32.8 2.0 0.00018 21.9 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP43376.1 - 4.8e-06 26.8 1.7 0.00097 19.4 0.3 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_20 PF14561.6 EDP43376.1 - 2.5e-05 24.5 5.0 0.0074 16.6 0.5 2.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDP43376.1 - 0.00012 22.1 0.7 0.0028 17.8 0.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDP43376.1 - 0.00019 21.8 1.8 6.6 7.6 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 EDP43376.1 - 0.0065 16.2 1.4 0.008 15.9 0.4 1.7 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain DUF5344 PF17279.2 EDP43376.1 - 0.0092 16.5 0.0 0.021 15.4 0.0 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5344) DUF3502 PF12010.8 EDP43376.1 - 0.037 14.7 0.0 0.042 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) HSCB_C PF07743.13 EDP43376.1 - 0.078 13.5 1.6 0.1 13.1 0.6 1.7 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain TPR_7 PF13176.6 EDP43376.1 - 0.2 11.8 2.7 0.73 10.0 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RTC4 PF14474.6 EDP43377.1 - 3.9e-15 56.1 0.0 7.6e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Sde2_N_Ubi PF13019.6 EDP43378.1 - 5.6e-32 110.8 0.4 5.6e-32 110.8 0.4 1.6 2 1 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain PSII_Pbs27 PF13326.6 EDP43378.1 - 0.38 11.1 4.9 1.1 9.5 4.5 1.9 1 1 0 1 1 1 0 Photosystem II Pbs27 Pheromone PF08015.11 EDP43378.1 - 0.66 11.1 3.9 1.3 10.1 3.9 1.4 1 0 0 1 1 1 0 Fungal mating-type pheromone Amidase PF01425.21 EDP43379.1 - 1.7e-46 159.2 0.0 1.9e-46 159.0 0.0 1.0 1 0 0 1 1 1 1 Amidase Mito_carr PF00153.27 EDP43380.1 - 8.5e-55 182.7 7.4 2e-19 69.3 0.0 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 EDP43380.1 - 0.00013 21.2 0.4 0.00086 18.5 0.4 2.3 1 1 0 1 1 1 1 Gammaproteobacterial serine protease Nop52 PF05997.12 EDP43381.1 - 5.6e-74 248.6 0.1 7.9e-74 248.1 0.1 1.2 1 0 0 1 1 1 1 Nucleolar protein,Nop52 MMS19_N PF14500.6 EDP43381.1 - 0.014 15.0 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II NOT2_3_5 PF04153.18 EDP43381.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family Dabb PF07876.12 EDP43382.1 - 1e-09 38.9 0.1 1.1e-09 38.8 0.1 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Hamartin PF04388.12 EDP43383.1 - 0.51 8.9 2.5 0.85 8.2 2.5 1.3 1 0 0 1 1 1 0 Hamartin protein PIG-S PF10510.9 EDP43384.1 - 2.1e-101 340.3 3.2 6.6e-89 299.1 0.1 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein Pex24p PF06398.11 EDP43385.1 - 2e-28 99.4 9.2 5.8e-28 97.9 9.2 1.7 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin ATP12 PF07542.11 EDP43386.1 - 1.4e-40 138.3 0.1 2.9e-40 137.3 0.1 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein Erythro-docking PF09277.11 EDP43386.1 - 0.0034 17.3 0.0 0.014 15.3 0.0 2.0 1 0 0 1 1 1 1 Erythronolide synthase, docking Ribosomal_S17_N PF16205.5 EDP43386.1 - 0.031 14.7 0.0 0.065 13.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal TPR_1 PF00515.28 EDP43387.1 - 3.2e-07 29.9 2.7 0.0091 15.8 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDP43387.1 - 4.5e-06 26.4 9.7 0.00083 19.3 0.3 3.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43387.1 - 0.00085 19.4 0.5 1.2 9.5 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43387.1 - 0.0012 19.5 0.2 0.61 10.8 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDP43387.1 - 0.0051 16.5 1.1 3 7.6 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_14 PF13428.6 EDP43387.1 - 0.0061 17.3 3.8 0.019 15.8 0.5 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDP43387.1 - 0.0063 16.8 0.4 2.6 8.4 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP43387.1 - 0.099 12.7 0.2 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43387.1 - 0.15 12.6 5.2 0.21 12.1 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP43387.1 - 0.35 11.1 3.3 5.8 7.2 0.8 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EDP43387.1 - 1.1 9.4 3.2 1.5 8.9 0.1 2.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat NADH-u_ox-rdase PF10785.9 EDP43388.1 - 1.4e-30 105.8 0.1 2e-30 105.3 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 EDP43388.1 - 0.0023 17.9 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit RsfS PF02410.15 EDP43389.1 - 6.9e-09 36.1 0.6 1.7e-08 34.8 0.1 2.1 3 0 0 3 3 3 1 Ribosomal silencing factor during starvation Neugrin PF06413.11 EDP43389.1 - 4.7e-08 33.3 0.1 6.7e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 EDP43389.1 - 6.9e-06 26.3 1.1 1.2e-05 25.6 1.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 DUF2894 PF11445.8 EDP43389.1 - 0.0019 18.7 0.4 0.0047 17.4 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2894) MarR_2 PF12802.7 EDP43389.1 - 0.056 13.3 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 MarR family Clat_adaptor_s PF01217.20 EDP43390.1 - 1.5e-41 141.7 0.4 1.7e-41 141.5 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SYS1 PF09801.9 EDP43391.1 - 1.5e-22 80.3 8.7 1.3e-16 61.1 5.9 2.3 2 0 0 2 2 2 2 Integral membrane protein S linking to the trans Golgi network Mannosyl_trans2 PF04188.13 EDP43392.1 - 9.7e-53 180.0 10.8 1.6e-52 179.4 10.8 1.3 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) SRP54 PF00448.22 EDP43393.1 - 4.4e-75 251.6 0.1 7.4e-75 250.9 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EDP43393.1 - 1.5e-31 108.9 1.4 1.5e-31 108.9 1.4 3.8 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 EDP43393.1 - 5.1e-17 61.9 0.5 1.2e-16 60.7 0.5 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EDP43393.1 - 6.3e-05 22.1 0.2 0.0029 16.6 0.0 3.0 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EDP43393.1 - 0.00011 22.5 0.0 0.00055 20.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP43393.1 - 0.00015 21.9 0.7 0.00039 20.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EDP43393.1 - 0.00018 21.1 0.1 0.0015 18.1 0.1 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EDP43393.1 - 0.0052 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.6 EDP43393.1 - 0.011 16.2 0.2 0.049 14.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EDP43393.1 - 0.02 14.8 0.0 0.058 13.3 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.6 EDP43393.1 - 0.024 15.0 0.4 0.11 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Thymidylate_kin PF02223.17 EDP43393.1 - 0.028 14.1 0.9 0.25 11.0 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase CbiA PF01656.23 EDP43393.1 - 0.029 14.4 0.0 0.11 12.5 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_8 PF12780.7 EDP43393.1 - 0.051 12.9 0.1 7.4 5.8 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_30 PF13604.6 EDP43393.1 - 0.051 13.3 0.0 0.051 13.3 0.0 2.5 3 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EDP43393.1 - 0.053 14.1 0.1 0.23 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDP43393.1 - 0.056 13.2 0.1 0.48 10.1 0.0 2.2 1 1 1 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EDP43393.1 - 0.063 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF3052 PF11253.8 EDP43393.1 - 0.075 13.0 0.2 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) AAA_28 PF13521.6 EDP43393.1 - 0.082 13.1 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain MecA PF05389.12 EDP43393.1 - 0.1 12.2 1.5 0.2 11.2 0.3 2.0 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) AAA_31 PF13614.6 EDP43393.1 - 0.16 11.9 0.1 0.77 9.6 0.0 2.0 1 1 1 2 2 2 0 AAA domain ResIII PF04851.15 EDP43393.1 - 0.19 11.7 0.7 2.2 8.3 0.1 2.4 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit ArsA_ATPase PF02374.15 EDP43393.1 - 0.24 10.6 1.3 1.1 8.3 0.0 2.5 3 0 0 3 3 3 0 Anion-transporting ATPase SRPRB PF09439.10 EDP43393.1 - 0.8 9.1 3.2 4.7 6.6 0.7 3.0 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit CALM_bind PF16025.5 EDP43393.1 - 1.1 9.8 7.4 0.095 13.2 1.0 2.5 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding XPG_I PF00867.18 EDP43394.1 - 2e-06 28.1 0.2 8.1e-06 26.1 0.2 1.9 2 0 0 2 2 2 1 XPG I-region Ribosomal_L10 PF00466.20 EDP43395.1 - 5.8e-05 23.2 0.1 0.0027 17.8 0.2 2.3 2 0 0 2 2 2 2 Ribosomal protein L10 Hydrolase PF00702.26 EDP43397.1 - 3e-14 53.8 0.0 4.4e-07 30.4 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EDP43397.1 - 0.00029 20.4 0.8 0.00029 20.4 0.8 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EDP43397.1 - 0.0017 18.2 1.1 0.0029 17.4 1.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EDP43398.1 - 1.9e-31 108.3 0.2 2.7e-15 56.6 0.0 2.7 2 0 0 2 2 2 2 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EDP43398.1 - 2.1e-17 63.2 1.1 6.7e-17 61.6 0.1 2.2 2 0 0 2 2 2 1 E1-E2 ATPase DUF2997 PF11211.8 EDP43398.1 - 0.092 12.5 0.1 16 5.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2997) Tweety PF04906.13 EDP43398.1 - 0.1 11.2 1.7 0.9 8.1 0.1 2.1 2 0 0 2 2 2 0 Tweety Fer2_BFD PF04324.15 EDP43398.1 - 0.13 12.6 0.1 2.9 8.3 0.0 2.5 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain DUF3433 PF11915.8 EDP43398.1 - 4.7 7.7 6.4 4.6 7.8 4.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3433) Ribosomal_L12 PF00542.19 EDP43399.1 - 1.4e-20 73.4 8.8 1.5e-19 70.1 6.6 2.2 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EDP43399.1 - 9.2e-17 60.5 5.9 9.2e-17 60.5 5.9 3.3 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EDP43399.1 - 0.00078 20.0 5.3 0.00078 20.0 5.3 3.3 3 1 0 3 3 3 1 60s Acidic ribosomal protein DUF3275 PF11679.8 EDP43399.1 - 1.3 9.0 4.0 0.68 9.9 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) ERG4_ERG24 PF01222.17 EDP43400.1 - 1.5e-116 389.7 19.3 1.6e-116 389.6 19.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Sulfate_transp PF00916.20 EDP43400.1 - 0.012 14.4 0.8 0.017 13.9 0.8 1.2 1 0 0 1 1 1 0 Sulfate permease family Syja_N PF02383.18 EDP43401.1 - 9.7e-78 261.7 0.0 1.5e-77 261.1 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Proteasome PF00227.26 EDP43402.1 - 2.7e-51 173.8 0.2 3.5e-51 173.4 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Transposase_28 PF04195.12 EDP43402.1 - 0.073 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Putative gypsy type transposon NKAIN PF05640.14 EDP43403.1 - 0.047 12.9 0.9 0.063 12.5 0.9 1.2 1 0 0 1 1 1 0 Na,K-Atpase Interacting protein FTR1 PF03239.14 EDP43403.1 - 0.08 12.1 0.9 0.1 11.8 0.9 1.1 1 0 0 1 1 1 0 Iron permease FTR1 family Homoserine_dh PF00742.19 EDP43404.1 - 5.2e-48 163.2 0.0 7.6e-48 162.7 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EDP43404.1 - 2.8e-17 63.4 0.5 6e-17 62.4 0.1 1.8 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain p450 PF00067.22 EDP43405.1 - 1.8e-77 261.1 0.0 3.3e-77 260.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 NUDIX PF00293.28 EDP43406.1 - 1.3e-09 38.2 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUP PF06516.11 EDP43407.1 - 3.5e-84 282.7 0.0 4e-84 282.5 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) YpM PF09144.10 EDP43407.1 - 0.082 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Yersinia pseudo-tuberculosis mitogen K_oxygenase PF13434.6 EDP43408.1 - 1.9e-06 27.3 0.0 0.00038 19.7 0.0 2.7 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 EDP43408.1 - 0.023 14.0 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EDP43408.1 - 0.025 13.8 0.1 4.3 6.5 0.2 2.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP43408.1 - 0.067 13.2 0.4 1.9 8.5 0.1 3.0 2 1 1 3 3 3 0 FAD-NAD(P)-binding DUF3454 PF11936.8 EDP43408.1 - 0.077 13.4 2.4 0.18 12.3 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3454) Pyr_redox_3 PF13738.6 EDP43408.1 - 0.11 11.7 0.0 5.2 6.2 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAM183 PF14886.6 EDP43408.1 - 0.11 13.2 0.1 0.27 12.0 0.1 1.6 1 0 0 1 1 1 0 FAM183A and FAM183B related PHD PF00628.29 EDP43410.1 - 3.3e-05 23.7 7.1 5.2e-05 23.0 7.1 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EDP43410.1 - 0.0016 18.6 1.1 0.0028 17.9 1.1 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RanBP PF00641.18 EDP43410.1 - 0.031 13.6 0.2 0.053 12.8 0.2 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-C4pol PF14260.6 EDP43410.1 - 0.2 12.1 4.0 0.62 10.6 0.6 2.3 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta NAD_binding_6 PF08030.12 EDP43412.1 - 4.4e-17 62.6 0.0 5.8e-10 39.5 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EDP43412.1 - 1.5e-15 57.5 15.5 1.5e-15 57.5 15.5 2.2 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EDP43412.1 - 6.9e-13 48.6 0.0 2.4e-12 46.9 0.0 1.9 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EDP43412.1 - 0.013 16.2 0.0 0.044 14.4 0.0 2.0 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain S_4TM PF18159.1 EDP43412.1 - 0.68 9.2 2.9 6.2 6.0 1.8 2.3 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain DHHC PF01529.20 EDP43413.1 - 6.7e-10 39.2 10.5 6.7e-10 39.2 10.5 3.1 2 1 1 3 3 3 1 DHHC palmitoyltransferase DEAD PF00270.29 EDP43415.1 - 3e-34 118.3 0.2 4.4e-34 117.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43415.1 - 7.1e-33 113.3 0.0 2.2e-32 111.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43415.1 - 2.6e-05 24.3 0.0 6.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DHHA2 PF02833.14 EDP43416.1 - 7.8e-27 94.2 0.1 1.3e-26 93.5 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EDP43416.1 - 8.4e-11 42.0 0.2 8.4e-11 42.0 0.2 1.8 2 0 0 2 2 2 1 DHH family Pex26 PF07163.12 EDP43416.1 - 0.035 13.4 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Pex26 protein TPR_2 PF07719.17 EDP43417.1 - 1e-17 62.7 6.1 0.0014 18.6 0.1 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EDP43417.1 - 2e-17 62.2 0.3 2.3e-05 24.0 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43417.1 - 1.1e-13 50.1 6.1 0.068 13.4 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDP43417.1 - 1.1e-12 47.4 2.8 0.0051 16.5 0.3 4.5 2 1 2 4 4 4 3 TPR repeat TPR_12 PF13424.6 EDP43417.1 - 9.7e-10 38.6 4.5 0.24 11.7 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43417.1 - 1.6e-09 38.2 7.8 0.021 15.3 0.0 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43417.1 - 1.8e-08 34.5 12.8 0.025 15.4 0.1 6.7 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43417.1 - 3.7e-08 33.9 6.3 0.00036 21.1 0.1 4.2 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP43417.1 - 3e-06 27.2 5.2 0.00093 19.4 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 EDP43417.1 - 2e-05 24.8 8.5 0.015 15.6 0.5 4.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP43417.1 - 0.0013 18.6 8.0 1.5 9.0 0.1 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP43417.1 - 0.0055 17.3 4.5 1.2 9.9 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EDP43417.1 - 0.026 14.7 4.7 0.17 12.1 0.6 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat Coatomer_E PF04733.14 EDP43417.1 - 0.056 12.9 3.7 4.4 6.6 0.5 2.8 2 1 0 2 2 2 0 Coatomer epsilon subunit ANAPC3 PF12895.7 EDP43417.1 - 0.093 13.0 3.7 13 6.1 1.1 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MAS20 PF02064.15 EDP43417.1 - 0.6 10.2 4.4 92 3.1 0.0 4.0 3 1 0 4 4 4 0 MAS20 protein import receptor TPR_10 PF13374.6 EDP43417.1 - 7.5 6.6 7.7 8.5 6.4 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Pro_isomerase PF00160.21 EDP43418.1 - 3.6e-42 144.3 0.0 5.3e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 EDP43419.1 - 0.0066 15.9 0.0 0.034 13.5 0.0 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger Vps39_2 PF10367.9 EDP43420.1 - 2.4e-08 34.4 0.1 6.9e-08 32.9 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EDP43420.1 - 4.1e-05 23.3 0.0 8.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 EDP43420.1 - 0.09 12.6 0.3 1.5 8.7 0.0 2.7 2 1 0 2 2 2 0 Region in Clathrin and VPS TPR_12 PF13424.6 EDP43420.1 - 0.26 11.6 5.0 11 6.4 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PolyA_pol PF01743.20 EDP43421.1 - 7e-20 71.7 0.0 1.9e-19 70.3 0.0 1.8 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EDP43421.1 - 2.4e-08 33.6 0.0 5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A Pkinase PF00069.25 EDP43422.1 - 3e-63 213.6 0.0 3.9e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43422.1 - 9.5e-29 100.4 0.0 1.5e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43422.1 - 3.5e-05 23.3 0.0 7.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP43422.1 - 0.021 14.7 0.7 0.16 11.8 0.1 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP43422.1 - 0.083 11.8 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EDP43422.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 UAA PF08449.11 EDP43423.1 - 2.9e-40 138.3 20.8 8.2e-38 130.3 20.8 2.6 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDP43423.1 - 2e-07 31.2 26.8 7.7e-06 26.1 8.4 4.0 4 1 0 4 4 4 2 EamA-like transporter family CRT-like PF08627.10 EDP43423.1 - 0.00057 18.9 13.6 0.052 12.5 4.9 2.3 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 EDP43423.1 - 0.0012 18.3 6.6 0.013 14.8 1.4 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family SLC35F PF06027.12 EDP43423.1 - 0.021 14.4 10.0 0.29 10.6 2.0 2.5 2 0 0 2 2 2 0 Solute carrier family 35 Nuc_sug_transp PF04142.15 EDP43423.1 - 0.041 13.1 10.1 0.33 10.1 0.4 2.5 2 1 0 2 2 2 0 Nucleotide-sugar transporter TMEM234 PF10639.9 EDP43423.1 - 1.5 8.9 9.6 4.8 7.2 2.2 3.0 2 1 1 3 3 3 0 Putative transmembrane family 234 DAP3 PF10236.9 EDP43424.1 - 3.1e-50 171.1 0.0 4e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 EDP43424.1 - 1.1e-08 35.6 0.0 2.4e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EDP43424.1 - 0.00062 19.4 0.0 0.015 14.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDP43424.1 - 0.0076 16.5 0.1 0.048 13.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDP43424.1 - 0.023 14.7 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EDP43424.1 - 0.039 13.7 0.0 0.092 12.5 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 EDP43424.1 - 0.11 12.4 0.0 0.36 10.7 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 EDP43424.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 EDP43427.1 - 9.5e-49 165.6 0.0 1.6e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDP43427.1 - 1.3e-18 66.9 0.0 2.3e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDP43427.1 - 1.6e-10 41.2 0.0 4.2e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDP43427.1 - 0.00018 21.3 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EDP43427.1 - 0.004 17.2 0.0 0.035 14.2 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF866 PF05907.13 EDP43428.1 - 7.1e-46 155.9 0.1 8.8e-46 155.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Cytochrome_C7 PF14522.6 EDP43428.1 - 0.0082 16.1 0.1 0.013 15.4 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c Zn-ribbon_8 PF09723.10 EDP43428.1 - 0.084 13.0 1.6 0.93 9.7 1.6 2.5 1 1 0 1 1 1 0 Zinc ribbon domain CDP-OH_P_transf PF01066.21 EDP43429.1 - 2.6e-13 50.5 1.1 1.7e-12 47.9 0.2 2.4 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase VHS PF00790.19 EDP43430.1 - 1.1e-05 25.3 0.0 3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EDP43430.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.7 1 1 0 1 1 1 0 GAT domain Metallophos PF00149.28 EDP43431.1 - 8.4e-40 137.5 0.2 1.2e-39 137.0 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDP43431.1 - 0.051 14.0 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain FAD-oxidase_C PF02913.19 EDP43432.1 - 2.8e-55 187.7 0.0 3.6e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EDP43432.1 - 2.4e-35 121.3 0.1 4e-35 120.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HIG_1_N PF04588.13 EDP43433.1 - 5.8e-05 23.2 0.2 9.7e-05 22.5 0.2 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Nop53 PF07767.11 EDP43434.1 - 3.4e-93 313.2 24.3 4.1e-93 312.9 24.3 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Dermcidin PF15291.6 EDP43434.1 - 4 8.1 6.7 0.77 10.3 0.5 2.7 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide OST3_OST6 PF04756.13 EDP43435.1 - 4.7e-75 252.7 0.0 5.4e-75 252.5 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family RseC_MucC PF04246.12 EDP43435.1 - 0.06 13.3 6.5 0.52 10.3 0.6 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF4131 PF13567.6 EDP43435.1 - 0.088 12.5 6.8 2.7 7.6 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) CcmH PF03918.14 EDP43435.1 - 0.16 11.2 0.2 1.6 8.0 0.0 2.5 3 0 0 3 3 3 0 Cytochrome C biogenesis protein Ribosomal_L16 PF00252.18 EDP43436.1 - 8.6e-35 119.6 0.0 1.1e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Pribosyltran PF00156.27 EDP43437.1 - 3.9e-13 49.2 0.1 6.4e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 EDP43437.1 - 0.014 14.9 0.3 0.021 14.3 0.3 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase RnfC_N PF13375.6 EDP43437.1 - 0.016 15.1 0.4 0.028 14.4 0.4 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain WD40 PF00400.32 EDP43438.1 - 1.4e-45 152.4 24.6 6.2e-07 30.0 1.3 8.2 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43438.1 - 1.1e-08 35.3 0.2 0.59 10.5 0.0 5.8 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP43438.1 - 0.00029 19.9 0.0 0.25 10.2 0.0 3.8 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EDP43438.1 - 0.00038 19.6 0.0 1.1 8.3 0.0 2.7 3 0 0 3 3 3 2 VID27 C-terminal WD40-like domain LisH_TPL PF17814.1 EDP43438.1 - 0.1 12.3 0.0 0.37 10.5 0.0 2.0 1 0 0 1 1 1 0 LisH-like dimerisation domain Nup160 PF11715.8 EDP43438.1 - 1.8 7.1 5.6 20 3.6 0.0 3.7 3 1 1 4 4 4 0 Nucleoporin Nup120/160 HIT PF01230.23 EDP43439.1 - 1.1e-22 80.6 0.1 1.4e-22 80.2 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDP43439.1 - 2.6e-12 47.2 0.2 3.8e-12 46.7 0.2 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EDP43439.1 - 0.00015 21.6 0.1 0.00024 21.0 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Cid2 PF09774.9 EDP43440.1 - 6e-30 104.8 2.0 7.9e-30 104.4 2.0 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 NAD_Gly3P_dh_C PF07479.14 EDP43441.1 - 3e-46 157.2 0.0 5.1e-46 156.5 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 EDP43441.1 - 4.5e-44 150.2 0.1 6.2e-44 149.7 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 EDP43441.1 - 0.00042 20.8 0.3 1.4 9.6 0.1 2.5 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent EI24 PF07264.11 EDP43443.1 - 1.3e-18 67.8 4.8 1.7e-18 67.5 4.8 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Glyco_hydro_3_C PF01915.22 EDP43444.1 - 8.6e-57 192.4 0.0 1.2e-56 191.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EDP43444.1 - 1.1e-42 146.6 0.0 1.9e-42 145.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EDP43444.1 - 1.2e-18 66.9 0.0 2.5e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain NUDIX PF00293.28 EDP43446.1 - 8.8e-10 38.7 0.0 1.7e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain zf-U1 PF06220.12 EDP43447.1 - 4.1e-18 64.9 7.0 5.4e-18 64.5 7.0 1.2 1 0 0 1 1 1 1 U1 zinc finger CLIP1_ZNF PF16641.5 EDP43447.1 - 1.8 8.5 6.4 0.18 11.7 2.3 1.5 2 0 0 2 2 2 0 CLIP1 zinc knuckle DEAD PF00270.29 EDP43448.1 - 1.1e-42 145.7 0.0 2e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43448.1 - 3.9e-23 81.9 0.0 1.7e-22 79.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43448.1 - 5.2e-05 23.3 0.0 9.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Thiamine_BP PF01910.17 EDP43449.1 - 9e-19 67.2 0.1 1e-16 60.6 0.1 2.1 1 1 0 1 1 1 1 Thiamine-binding protein Aminotran_3 PF00202.21 EDP43450.1 - 6.6e-93 311.6 0.0 1e-92 310.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III His_Phos_2 PF00328.22 EDP43451.1 - 1.8e-45 156.0 0.0 4.9e-45 154.5 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) GATase_6 PF13522.6 EDP43452.1 - 5.5e-15 55.7 0.0 1.4e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EDP43452.1 - 7.3e-11 42.1 0.0 2e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EDP43452.1 - 7e-09 35.4 0.1 1.3e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EDP43452.1 - 0.00023 20.2 0.0 0.0004 19.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Mito_carr PF00153.27 EDP43453.1 - 1.6e-61 204.3 4.9 7.3e-20 70.7 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Y_phosphatase2 PF03162.13 EDP43454.1 - 8.6e-22 77.5 0.0 8.8e-22 77.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EDP43455.1 - 2.6e-14 53.1 0.0 2.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family SulA PF03846.14 EDP43455.1 - 0.047 13.6 0.0 0.062 13.2 0.0 1.1 1 0 0 1 1 1 0 Cell division inhibitor SulA Aldo_ket_red PF00248.21 EDP43456.1 - 4.7e-21 75.2 0.0 1.3e-15 57.4 0.0 2.3 2 1 0 2 2 2 2 Aldo/keto reductase family Chitin_synth_2 PF03142.15 EDP43457.1 - 0.0065 15.1 0.5 0.0082 14.8 0.5 1.1 1 0 0 1 1 1 1 Chitin synthase DHDPS PF00701.22 EDP43458.1 - 0.083 11.6 0.0 0.2 10.3 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family FlgN PF05130.12 EDP43458.1 - 0.23 12.0 5.1 0.39 11.2 0.1 2.7 2 0 0 2 2 2 0 FlgN protein Ribosomal_S9 PF00380.19 EDP43459.1 - 3.3e-24 85.7 0.0 5e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Arg_decarb_HB PF17810.1 EDP43459.1 - 0.002 18.3 0.1 0.0058 16.9 0.1 1.8 2 0 0 2 2 2 1 Arginine decarboxylase helical bundle domain MotA_ExbB PF01618.16 EDP43459.1 - 0.086 12.6 0.9 0.2 11.4 0.9 1.6 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family Ribosomal_S11 PF00411.19 EDP43460.1 - 1.9e-15 57.2 0.1 4e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S11 Hat1_N PF10394.9 EDP43461.1 - 2.7e-46 157.7 0.0 4.8e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EDP43461.1 - 0.00028 21.1 0.0 0.00054 20.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDP43461.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TIP41 PF04176.13 EDP43462.1 - 1.7e-13 50.4 1.0 5.8e-12 45.4 1.0 2.0 1 1 0 1 1 1 1 TIP41-like family DLH PF01738.18 EDP43463.1 - 2.3e-12 46.9 0.0 2.8e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Aspzincin_M35 PF14521.6 EDP43463.1 - 0.13 12.8 0.4 0.73 10.4 0.2 2.1 2 0 0 2 2 2 0 Lysine-specific metallo-endopeptidase Cation_efflux PF01545.21 EDP43464.1 - 2.4e-49 167.8 15.5 2.4e-49 167.8 15.5 3.9 2 1 0 2 2 2 1 Cation efflux family RasGEF PF00617.19 EDP43465.1 - 3.5e-53 180.4 0.1 7.2e-53 179.4 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EDP43465.1 - 4.9e-22 78.2 0.1 1.3e-21 76.8 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif WD40 PF00400.32 EDP43466.1 - 3.3e-10 40.4 4.3 0.033 15.1 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat MCM PF00493.23 EDP43467.1 - 8.2e-103 342.3 0.0 1.3e-102 341.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP43467.1 - 3.5e-33 114.1 0.0 6e-33 113.4 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDP43467.1 - 6e-27 93.9 3.7 1.4e-26 92.8 3.7 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EDP43467.1 - 6.1e-07 29.0 0.0 0.00013 21.4 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDP43467.1 - 1.1e-05 25.5 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDP43467.1 - 0.00049 20.0 0.0 0.0034 17.2 0.0 2.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RBD-FIP PF09457.10 EDP43467.1 - 0.045 13.7 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 FIP domain Sigma54_activat PF00158.26 EDP43467.1 - 0.12 12.1 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 EDP43467.1 - 0.17 12.6 1.8 0.53 11.0 1.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal Band_7 PF01145.25 EDP43468.1 - 3.3e-20 72.8 0.4 5.6e-20 72.1 0.4 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family GRP PF07172.11 EDP43468.1 - 0.016 15.9 8.5 0.027 15.2 8.5 1.3 1 0 0 1 1 1 0 Glycine rich protein family RA PF00788.23 EDP43469.1 - 1.1e-13 51.6 0.2 3.3e-11 43.7 0.0 3.3 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 EDP43469.1 - 1.4e-07 31.0 0.0 2.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP43469.1 - 0.0015 18.3 0.0 0.003 17.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TUG-UBL1 PF11470.8 EDP43469.1 - 0.079 13.2 0.1 0.75 10.1 0.1 2.3 2 0 0 2 2 2 0 TUG ubiquitin-like domain BUD22 PF09073.10 EDP43469.1 - 1.9 7.7 10.1 5.5 6.2 10.1 1.7 1 0 0 1 1 1 0 BUD22 Chitin_synth_2 PF03142.15 EDP43470.1 - 5.1e-90 302.6 1.7 6e-90 302.3 1.7 1.0 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EDP43470.1 - 0.072 13.0 8.9 0.28 11.1 8.9 1.9 1 1 0 1 1 1 0 Glycosyl transferase family group 2 Chitin_synth_2 PF03142.15 EDP43471.1 - 1.6e-146 489.1 0.0 2.4e-146 488.5 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 EDP43471.1 - 1.3e-06 28.5 0.0 4.9e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EDP43471.1 - 0.00039 19.9 0.0 0.00072 19.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 EDP43471.1 - 0.00043 20.3 0.2 0.0018 18.2 0.0 2.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EDP43471.1 - 0.019 14.8 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 UPF0258 PF06789.12 EDP43471.1 - 0.38 10.9 1.2 0.81 9.8 0.2 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) RRM_1 PF00076.22 EDP43472.1 - 1.8e-16 59.7 0.0 2e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP43472.1 - 5.1e-05 22.9 0.0 5.6e-05 22.7 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP43472.1 - 0.082 12.8 0.0 0.099 12.5 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_8 PF11835.8 EDP43472.1 - 0.12 12.5 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 RRM-like domain RRM_3 PF08777.11 EDP43472.1 - 0.13 12.3 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 RNA binding motif FIST PF08495.10 EDP43473.1 - 3e-10 40.4 0.0 4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 FIST N domain MoaC PF01967.21 EDP43474.1 - 5.7e-08 32.9 0.7 0.0027 17.8 0.0 2.2 2 0 0 2 2 2 2 MoaC family PrpF PF04303.13 EDP43475.1 - 8.5e-53 179.6 0.1 1.8e-37 129.2 0.0 2.6 2 1 0 2 2 2 2 PrpF protein GDP_Man_Dehyd PF16363.5 EDP43476.1 - 2.3e-49 168.6 0.0 2.6e-49 168.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EDP43476.1 - 1.4e-41 142.6 0.0 1.6e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EDP43476.1 - 7.7e-11 41.5 0.0 1.3e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EDP43476.1 - 3.1e-09 36.3 0.0 7.2e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EDP43476.1 - 9.9e-09 34.7 0.0 5.9e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EDP43476.1 - 1e-07 31.4 0.0 1.8e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EDP43476.1 - 0.00046 20.1 0.0 0.006 16.5 0.0 2.3 2 1 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EDP43476.1 - 0.00081 19.3 0.0 0.002 18.0 0.0 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EDP43476.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EDP43476.1 - 0.2 11.9 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RPA_interact_C PF14768.6 EDP43478.1 - 0.0013 19.3 0.0 0.0021 18.6 0.0 1.3 1 0 0 1 1 1 1 Replication protein A interacting C-terminal Ribosomal_L11_N PF03946.14 EDP43479.1 - 6.5e-20 70.7 0.1 1.1e-19 70.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EDP43479.1 - 2e-16 60.2 0.2 3e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain WD40 PF00400.32 EDP43480.1 - 3.8e-39 132.0 18.2 9.6e-10 38.9 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43480.1 - 8.7e-12 45.2 0.2 0.029 14.7 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP43480.1 - 1.2e-05 24.2 0.8 0.02 13.6 0.1 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 EDP43480.1 - 0.00029 20.7 0.2 9.1 6.4 0.0 4.6 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EDP43480.1 - 0.0034 16.0 0.0 0.18 10.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain RRM_1 PF00076.22 EDP43481.1 - 7.5e-21 73.7 0.0 1e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP43481.1 - 0.024 14.5 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_7 PF16367.5 EDP43481.1 - 0.031 14.4 0.0 0.05 13.7 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif Glyoxal_oxid_N PF07250.11 EDP43482.1 - 1.5e-23 83.2 0.1 1.3e-12 47.4 0.0 4.4 2 1 1 4 4 4 3 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EDP43482.1 - 4.3e-21 75.0 0.4 1.1e-20 73.7 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1929) DUF4690 PF15756.5 EDP43482.1 - 0.021 15.4 0.0 0.14 12.8 0.0 2.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Podoplanin PF05808.11 EDP43482.1 - 0.07 13.2 1.1 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Podoplanin CYYR1 PF10873.8 EDP43482.1 - 0.11 12.9 0.2 0.47 10.9 0.0 2.2 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Syndecan PF01034.20 EDP43482.1 - 0.17 11.8 0.3 0.37 10.8 0.3 1.5 1 0 0 1 1 1 0 Syndecan domain VSP PF03302.13 EDP43482.1 - 0.18 10.6 0.1 0.29 9.9 0.1 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF5122 PF17164.4 EDP43482.1 - 8.8 6.7 8.8 13 6.2 0.0 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Mito_carr PF00153.27 EDP43483.1 - 1.7e-62 207.4 1.7 1.7e-23 82.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EDP43483.1 - 0.034 13.3 1.5 4.5 6.3 0.1 3.1 2 1 1 3 3 3 0 Gammaproteobacterial serine protease Sec23_trunk PF04811.15 EDP43484.1 - 4.7e-55 186.8 0.0 8.6e-55 185.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDP43484.1 - 4.6e-24 84.2 0.0 8.1e-24 83.4 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EDP43484.1 - 1e-18 67.9 0.0 2.2e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EDP43484.1 - 3.3e-13 49.4 8.8 6.3e-13 48.6 8.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EDP43484.1 - 0.00028 20.7 0.0 0.00072 19.4 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Thymidylat_synt PF00303.19 EDP43485.1 - 2.2e-103 345.0 0.0 2.9e-103 344.7 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase His_Phos_1 PF00300.22 EDP43485.1 - 2.4e-37 128.5 1.2 8.8e-37 126.7 0.0 2.4 3 1 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) CD20 PF04103.15 EDP43486.1 - 0.18 11.9 0.2 0.27 11.3 0.2 1.3 1 0 0 1 1 1 0 CD20-like family zf-MYND PF01753.18 EDP43487.1 - 1.6e-07 31.2 13.6 3.3e-07 30.3 13.6 1.5 1 0 0 1 1 1 1 MYND finger Mur_ligase_M PF08245.12 EDP43488.1 - 0.0059 16.6 0.0 0.017 15.1 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain ATP_synt_H PF05493.13 EDP43489.1 - 1.4e-22 79.9 4.6 1.6e-22 79.7 4.6 1.1 1 0 0 1 1 1 1 ATP synthase subunit H Saf_2TM PF18303.1 EDP43489.1 - 0.0029 17.2 0.1 0.0033 17.0 0.1 1.1 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain CD20 PF04103.15 EDP43489.1 - 0.0068 16.5 3.1 0.0073 16.4 3.1 1.0 1 0 0 1 1 1 1 CD20-like family DUF4131 PF13567.6 EDP43489.1 - 0.24 11.0 1.3 0.3 10.7 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) RPA_C PF08784.11 EDP43490.1 - 2.6e-14 53.7 0.1 5.7e-14 52.6 0.1 1.6 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EDP43490.1 - 2.4e-08 33.8 0.0 3.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 EDP43490.1 - 0.00091 19.0 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Pur_ac_phosph_N PF16656.5 EDP43490.1 - 0.015 15.9 0.9 0.23 12.0 0.0 2.5 3 0 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain DUF4423 PF14394.6 EDP43490.1 - 0.049 13.3 0.0 0.14 11.8 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) HTH_36 PF13730.6 EDP43490.1 - 0.05 13.6 0.0 3.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain PLU-1 PF08429.11 EDP43491.1 - 1.2e-47 162.8 0.0 1.9e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 PLU-1-like protein JmjC PF02373.22 EDP43491.1 - 2.4e-41 140.7 1.1 4.3e-41 139.9 0.4 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase PHD PF00628.29 EDP43491.1 - 9.4e-20 70.3 55.0 1.1e-09 38.0 6.6 4.1 4 0 0 4 4 4 3 PHD-finger JmjN PF02375.17 EDP43491.1 - 3.1e-15 55.8 0.0 7.3e-15 54.6 0.0 1.7 1 0 0 1 1 1 1 jmjN domain ARID PF01388.21 EDP43491.1 - 1.4e-11 44.9 0.0 3.6e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 EDP43491.1 - 1.1e-10 41.8 3.7 1.1e-10 41.8 3.7 3.8 4 0 0 4 4 4 1 C5HC2 zinc finger C1_1 PF00130.22 EDP43491.1 - 0.0047 16.8 5.0 0.0047 16.8 5.0 5.2 4 1 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA PF00004.29 EDP43492.1 - 1.7e-40 138.5 0.0 2.7e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDP43492.1 - 5.7e-12 45.4 0.2 1.2e-11 44.4 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDP43492.1 - 2.3e-08 33.7 0.2 4.4e-08 32.8 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDP43492.1 - 2e-05 24.9 0.6 0.034 14.4 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 EDP43492.1 - 3.1e-05 24.2 0.0 6.5e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EDP43492.1 - 6.7e-05 22.2 0.0 0.00014 21.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EDP43492.1 - 0.00043 20.6 0.5 0.12 12.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EDP43492.1 - 0.00048 20.1 0.6 0.0031 17.5 0.2 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP43492.1 - 0.00065 20.1 0.5 0.013 15.9 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EDP43492.1 - 0.0024 17.7 0.0 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDP43492.1 - 0.0055 17.2 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP43492.1 - 0.0061 16.7 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDP43492.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EDP43492.1 - 0.018 14.4 0.1 0.31 10.3 0.1 2.3 1 1 1 2 2 2 0 KaiC AAA_14 PF13173.6 EDP43492.1 - 0.026 14.5 0.0 0.087 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EDP43492.1 - 0.029 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Prot_ATP_OB_N PF17758.1 EDP43492.1 - 0.03 14.0 1.6 0.086 12.5 0.0 2.6 4 0 0 4 4 3 0 Proteasomal ATPase OB N-terminal domain TIP49 PF06068.13 EDP43492.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain NB-ARC PF00931.22 EDP43492.1 - 0.12 11.6 0.1 0.76 8.9 0.0 2.2 3 0 0 3 3 3 0 NB-ARC domain RNA_helicase PF00910.22 EDP43492.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EDP43492.1 - 0.14 11.4 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EDP43492.1 - 0.14 11.5 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EDP43492.1 - 0.15 11.8 0.2 0.44 10.3 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDP43492.1 - 0.16 11.6 0.5 3.4 7.2 0.1 2.4 1 1 1 2 2 2 0 AAA domain Histone PF00125.24 EDP43492.1 - 0.41 11.0 3.4 0.79 10.1 0.1 2.4 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Tim17 PF02466.19 EDP43493.1 - 3.1e-35 120.9 5.1 8e-35 119.6 5.1 1.7 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Abhydrolase_2 PF02230.16 EDP43493.1 - 0.033 14.0 0.3 11 5.8 0.0 2.9 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase E1-E2_ATPase PF00122.20 EDP43494.1 - 4.7e-42 143.6 1.1 3.6e-39 134.1 0.3 3.2 2 1 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.26 EDP43494.1 - 2.7e-18 67.0 0.1 5.2e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDP43494.1 - 4.6e-07 29.4 0.0 1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDP43494.1 - 0.002 17.9 0.1 0.0042 16.9 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDP43494.1 - 0.028 14.5 0.0 0.064 13.3 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) YrvL PF14184.6 EDP43494.1 - 6.4 6.9 10.5 0.33 11.1 3.8 2.3 2 0 0 2 2 2 0 Regulatory protein YrvL Cpn60_TCP1 PF00118.24 EDP43495.1 - 1.9e-163 544.7 3.2 2.1e-163 544.5 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1572 PF07609.11 EDP43495.1 - 0.11 12.3 0.0 0.95 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1572) SNF2_N PF00176.23 EDP43498.1 - 5.7e-54 183.1 0.0 7.5e-53 179.5 0.0 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP43498.1 - 1e-14 54.8 0.0 3.6e-14 53.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EDP43498.1 - 9e-08 31.9 4.9 9e-08 31.9 4.9 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EDP43498.1 - 2.6e-07 30.8 0.0 4.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EDP43498.1 - 2.8e-06 27.0 3.7 2.8e-06 27.0 3.7 3.4 4 1 1 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP43498.1 - 1.9e-05 24.4 7.3 1.9e-05 24.4 7.3 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 EDP43498.1 - 4.9e-05 23.2 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 EDP43498.1 - 6.4e-05 22.8 5.7 6.4e-05 22.8 5.7 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDP43498.1 - 0.00015 21.8 2.8 0.00015 21.8 2.8 2.7 2 1 0 2 2 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EDP43498.1 - 0.00015 21.6 5.8 0.00015 21.6 5.8 2.9 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDP43498.1 - 0.0003 21.1 6.5 0.0003 21.1 6.5 3.2 3 1 0 3 3 2 1 Ring finger domain AAA_22 PF13401.6 EDP43498.1 - 0.033 14.5 0.0 0.12 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EDP43498.1 - 0.12 11.8 0.1 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Zn_Tnp_IS91 PF14319.6 EDP43498.1 - 2.9 8.0 11.6 0.81 9.8 0.9 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain HEAT_EZ PF13513.6 EDP43499.1 - 1.3 9.6 4.5 28 5.3 0.6 2.8 2 0 0 2 2 2 0 HEAT-like repeat WD40 PF00400.32 EDP43501.1 - 2.7e-26 91.3 11.0 8.1e-05 23.3 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.11 EDP43501.1 - 8.5e-05 22.5 0.0 0.00018 21.4 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A DEAD PF00270.29 EDP43502.1 - 5e-44 150.2 0.2 7.3e-44 149.6 0.2 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43502.1 - 1.5e-27 96.1 0.6 7.5e-27 93.9 0.3 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EDP43502.1 - 0.0028 17.0 0.1 0.0056 16.1 0.1 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 EDP43502.1 - 0.0032 17.5 0.0 0.0062 16.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EDP43502.1 - 0.035 14.5 0.2 0.053 13.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain Pam17 PF08566.10 EDP43503.1 - 1.8e-45 154.7 0.0 2e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 DnaJ PF00226.31 EDP43504.1 - 2.4e-16 59.6 0.2 4.4e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain SPOUT_MTase PF02590.17 EDP43504.1 - 0.065 13.2 1.2 0.11 12.5 1.2 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase OmpH PF03938.14 EDP43504.1 - 3.2 8.1 10.2 5.2 7.4 10.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RrnaAD PF00398.20 EDP43505.1 - 4.7e-22 78.3 0.0 7.3e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase RHH_4 PF13467.6 EDP43506.1 - 0.056 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Ribbon-helix-helix domain DUF2141 PF09912.9 EDP43506.1 - 0.11 12.5 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) APG17 PF04108.12 EDP43507.1 - 7.4e-11 41.8 8.7 2.2e-07 30.3 2.2 2.8 3 0 0 3 3 3 2 Autophagy protein Apg17 DUF2046 PF09755.9 EDP43507.1 - 0.0047 16.2 1.0 0.073 12.3 0.0 2.6 3 0 0 3 3 3 1 Uncharacterized conserved protein H4 (DUF2046) DUF5398 PF17376.2 EDP43507.1 - 0.048 14.3 0.3 0.23 12.1 0.0 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5398) DUF3416 PF11896.8 EDP43507.1 - 0.085 13.1 6.2 1.3 9.2 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3416) Baculo_PEP_C PF04513.12 EDP43507.1 - 0.095 12.7 4.2 3.4 7.7 1.0 3.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Synaptonemal_3 PF15191.6 EDP43507.1 - 0.1 12.4 0.3 1.4 8.8 0.1 2.7 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 DUF3231 PF11553.8 EDP43507.1 - 0.1 12.2 0.1 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) Tweety PF04906.13 EDP43507.1 - 0.24 10.1 3.6 3.3 6.3 0.2 2.6 2 1 0 3 3 3 0 Tweety Hjc PF01870.18 EDP43507.1 - 0.26 11.3 1.0 7.5 6.6 0.2 2.5 1 1 1 2 2 2 0 Archaeal holliday junction resolvase (hjc) PRKG1_interact PF15898.5 EDP43507.1 - 0.3 12.0 7.2 0.5 11.3 0.1 3.5 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain Fip1 PF05182.13 EDP43508.1 - 4e-20 71.0 0.7 6.9e-20 70.3 0.7 1.4 1 0 0 1 1 1 1 Fip1 motif MPC PF03650.13 EDP43509.1 - 2.2e-24 85.7 0.2 2.6e-24 85.5 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers FAA_hydrolase PF01557.18 EDP43510.1 - 2.8e-57 193.9 0.0 3.4e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Rossmann-like PF10727.9 EDP43511.1 - 1.3 8.8 8.4 3.6 7.5 2.4 2.3 2 0 0 2 2 2 0 Rossmann-like domain RNase_P_p30 PF01876.16 EDP43512.1 - 3.4e-47 160.7 0.0 1.7e-45 155.1 0.0 2.0 1 1 0 1 1 1 1 RNase P subunit p30 DUF4922 PF16269.5 EDP43513.1 - 0.024 14.4 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) HIT PF01230.23 EDP43513.1 - 0.063 14.0 0.0 0.16 12.7 0.0 1.7 1 1 0 1 1 1 0 HIT domain DUF4931 PF16285.5 EDP43513.1 - 0.077 12.3 0.0 0.24 10.7 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) Aa_trans PF01490.18 EDP43514.1 - 1.8e-42 145.5 11.9 2.2e-42 145.3 11.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Rad51 PF08423.11 EDP43515.1 - 3.7e-123 409.8 0.0 4.4e-123 409.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EDP43515.1 - 1.1e-10 41.4 0.1 1.6e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EDP43515.1 - 2.8e-10 40.1 0.1 3.7e-10 39.7 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EDP43515.1 - 2e-06 27.3 0.0 4e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EDP43515.1 - 0.0043 16.4 0.1 0.013 14.8 0.0 1.7 2 1 0 2 2 2 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 EDP43515.1 - 0.011 14.8 1.6 0.43 9.7 1.5 2.2 1 1 1 2 2 2 0 PAXNEB protein RPN5_C PF18098.1 EDP43516.1 - 0.019 15.1 0.6 0.044 13.9 0.6 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN5 C-terminal domain Snapin_Pallidin PF14712.6 EDP43516.1 - 0.075 13.5 0.0 0.28 11.6 0.0 2.0 1 0 0 1 1 1 0 Snapin/Pallidin Rad1 PF02144.16 EDP43517.1 - 2.9e-34 118.4 0.0 3.4e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 WD40 PF00400.32 EDP43518.1 - 9.7e-19 67.4 17.5 4.2e-08 33.7 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43518.1 - 0.00018 21.7 0.0 0.028 14.7 0.0 3.4 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP43518.1 - 0.02 13.9 0.0 0.27 10.2 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-H2C2_2 PF13465.6 EDP43519.1 - 2.9e-11 43.3 18.1 6e-06 26.4 0.1 4.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EDP43519.1 - 5.1e-11 42.4 22.4 5.2e-05 23.5 0.8 4.6 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP43519.1 - 5.7e-07 29.8 20.2 0.0032 18.2 0.8 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-MYST PF17772.1 EDP43519.1 - 0.088 12.4 0.3 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 MYST family zinc finger domain Myosin_head PF00063.21 EDP43520.1 - 1.1e-49 169.4 0.0 1.4e-49 169.0 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Microtub_bd PF16796.5 EDP43520.1 - 0.02 14.8 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Microtubule binding AAA_16 PF13191.6 EDP43520.1 - 0.022 15.1 0.4 0.11 12.9 0.4 2.2 1 1 0 1 1 1 0 AAA ATPase domain GRIP PF01465.20 EDP43520.1 - 0.066 13.1 0.2 0.2 11.6 0.2 1.8 1 0 0 1 1 1 0 GRIP domain AAA_22 PF13401.6 EDP43520.1 - 0.22 11.8 1.3 1.2 9.4 0.0 2.8 3 1 1 4 4 4 0 AAA domain Myosin_head PF00063.21 EDP43521.1 - 4.4e-09 35.1 0.0 4.7e-09 35.1 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF4288 PF14119.6 EDP43522.1 - 0.023 15.1 0.2 0.052 13.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) DUF2730 PF10805.8 EDP43522.1 - 0.058 13.5 0.1 0.097 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Maelstrom PF13017.6 EDP43524.1 - 0.02 14.6 0.1 0.024 14.3 0.1 1.1 1 0 0 1 1 1 0 piRNA pathway germ-plasm component DUF4288 PF14119.6 EDP43524.1 - 0.045 14.2 0.6 0.083 13.3 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) MFS_1 PF07690.16 EDP43525.1 - 1.2e-11 44.2 32.1 1.2e-11 44.2 32.1 2.3 1 1 0 2 2 2 1 Major Facilitator Superfamily Gemini_mov PF01708.16 EDP43525.1 - 0.94 9.3 0.0 0.94 9.3 0.0 2.7 3 0 0 3 3 3 0 Geminivirus putative movement protein Ipi1_N PF12333.8 EDP43526.1 - 9.8e-19 67.8 2.0 9.8e-19 67.8 2.0 2.9 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.6 EDP43526.1 - 0.055 13.9 0.1 0.33 11.4 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats DUF2786 PF10979.8 EDP43526.1 - 0.06 13.3 0.7 0.18 11.8 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) NUDIX PF00293.28 EDP43527.1 - 6.2e-14 52.2 0.0 9.3e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EDP43527.1 - 0.00014 22.5 0.0 0.0004 21.0 0.0 1.8 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EDP43527.1 - 0.0018 17.9 0.5 0.0032 17.1 0.5 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 EDP43527.1 - 0.14 11.9 0.3 0.27 11.0 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 EDP43527.1 - 0.14 12.0 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit Ribosomal_S19 PF00203.21 EDP43528.1 - 1.5e-27 95.3 0.0 1.8e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 PRK PF00485.18 EDP43529.1 - 2.2e-05 24.3 0.1 0.00017 21.4 0.1 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EDP43529.1 - 0.0014 19.2 0.0 0.0038 17.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDP43529.1 - 0.022 15.3 0.0 0.036 14.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EDP43529.1 - 0.065 13.4 0.1 0.24 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 EDP43529.1 - 0.094 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein CLP1_P PF16575.5 EDP43529.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_29 PF13555.6 EDP43529.1 - 0.11 12.2 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EDP43529.1 - 0.15 12.2 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase POB3_N PF17292.2 EDP43530.1 - 4.4e-25 87.9 0.1 1.9e-21 76.3 0.0 2.4 2 0 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 EDP43530.1 - 4.9e-24 84.0 0.0 1.4e-23 82.6 0.0 1.9 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EDP43530.1 - 1e-23 83.5 0.0 1e-21 77.1 0.0 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like CDC45 PF02724.14 EDP43530.1 - 0.0077 14.6 16.9 0.019 13.3 1.7 2.1 2 0 0 2 2 2 2 CDC45-like protein Na_trans_assoc PF06512.13 EDP43530.1 - 0.96 9.7 20.9 1 9.6 7.1 2.4 2 0 0 2 2 2 0 Sodium ion transport-associated BUD22 PF09073.10 EDP43530.1 - 1.1 8.5 33.9 0.58 9.4 11.8 2.1 2 0 0 2 2 2 0 BUD22 RNA_pol_3_Rpc31 PF11705.8 EDP43530.1 - 3.6 7.8 38.4 2.2 8.5 11.8 2.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2201_N PF13203.6 EDP43530.1 - 4.9 6.7 14.1 0.022 14.4 4.5 1.8 2 0 0 2 2 2 0 Putative metallopeptidase domain SDA1 PF05285.12 EDP43530.1 - 5.1 6.4 39.7 1.7 8.0 16.4 2.2 2 0 0 2 2 2 0 SDA1 zf-C3HC4_3 PF13920.6 EDP43531.1 - 0.00099 18.9 19.0 0.0047 16.8 19.0 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TFIIS_C PF01096.18 EDP43532.1 - 1.3e-12 47.3 0.1 1.7e-12 47.0 0.1 1.1 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 EDP43532.1 - 0.033 14.2 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zinc_ribbon_9 PF14369.6 EDP43532.1 - 0.12 12.6 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon TANGO2 PF05742.12 EDP43533.1 - 9.3e-59 199.5 0.0 1.3e-58 199.0 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Arrestin_C PF02752.22 EDP43535.1 - 0.00019 21.9 0.4 0.00037 20.9 0.4 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain PHC2_SAM_assoc PF16616.5 EDP43535.1 - 5.1 7.9 7.6 3.2 8.6 4.3 2.4 1 1 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Ribonuc_red_lgC PF02867.15 EDP43536.1 - 1.6e-186 621.0 0.0 2e-186 620.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EDP43536.1 - 4.1e-24 84.4 0.0 9.5e-24 83.2 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EDP43536.1 - 1.4e-07 32.0 0.1 3.1e-07 30.9 0.1 1.7 1 0 0 1 1 1 1 ATP cone domain MARVEL PF01284.23 EDP43537.1 - 4.7e-13 49.4 15.1 6.1e-13 49.0 14.8 1.3 1 1 0 1 1 1 1 Membrane-associating domain Yip1 PF04893.17 EDP43537.1 - 0.23 11.1 17.9 0.5 10.1 17.6 1.6 1 1 0 1 1 1 0 Yip1 domain DUF4064 PF13273.6 EDP43537.1 - 2 8.8 17.7 4.6 7.6 11.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) MitoNEET_N PF10660.9 EDP43537.1 - 3.6 7.7 4.7 0.73 9.9 0.2 2.1 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Brix PF04427.18 EDP43538.1 - 4.8e-17 62.7 0.0 7.4e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Brix domain Brix PF04427.18 EDP43539.1 - 1.1e-13 51.7 0.0 1.5e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Brix domain WD40 PF00400.32 EDP43540.1 - 4.6e-18 65.2 4.9 0.00026 21.7 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Methyltransf_16 PF10294.9 EDP43541.1 - 1.3e-12 47.8 0.0 1.6e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EDP43541.1 - 0.0011 18.4 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EDP43541.1 - 0.015 14.9 0.0 0.019 14.5 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain GidB PF02527.15 EDP43541.1 - 0.018 14.4 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Cons_hypoth95 PF03602.15 EDP43541.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 95 NNMT_PNMT_TEMT PF01234.17 EDP43541.1 - 0.2 10.8 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family PTCB-BRCT PF12738.7 EDP43542.1 - 4.9e-29 100.1 0.1 9.8e-11 41.4 0.0 4.2 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 EDP43542.1 - 5e-22 78.1 0.0 2.9e-08 34.0 0.0 4.7 4 1 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDP43542.1 - 5.7e-13 49.1 0.0 0.0017 18.7 0.0 4.2 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EDP43542.1 - 0.64 10.4 2.4 1.1e+02 3.2 0.0 4.1 5 0 0 5 5 5 0 DNA ligase 3 BRCT domain UDPGT PF00201.18 EDP43543.1 - 5.8e-05 22.1 0.1 7.8e-05 21.6 0.1 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.6 EDP43543.1 - 0.044 14.2 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 YL1_C PF08265.11 EDP43544.1 - 5.7e-15 54.8 0.2 9.2e-15 54.1 0.2 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain YL1 PF05764.13 EDP43544.1 - 2.4e-11 44.3 3.7 2.4e-11 44.3 3.7 2.1 2 0 0 2 2 2 1 YL1 nuclear protein RBD-FIP PF09457.10 EDP43544.1 - 0.089 12.7 1.5 0.15 12.0 1.5 1.4 1 0 0 1 1 1 0 FIP domain zf-HIT PF04438.16 EDP43544.1 - 0.2 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 HIT zinc finger Ribonuc_red_sm PF00268.21 EDP43545.1 - 1.2e-119 398.9 0.2 1.5e-119 398.6 0.2 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ndc80_HEC PF03801.13 EDP43546.1 - 1.2e-33 115.9 0.0 7e-33 113.4 0.0 2.1 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 EDP43546.1 - 1.2e-13 50.9 0.5 1.2e-13 50.9 0.5 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF5595) HOOK PF05622.12 EDP43546.1 - 0.0044 15.2 24.9 0.056 11.6 6.4 2.2 2 0 0 2 2 2 2 HOOK protein TMF_TATA_bd PF12325.8 EDP43546.1 - 0.015 15.5 0.7 0.015 15.5 0.7 4.4 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding HALZ PF02183.18 EDP43546.1 - 0.077 13.2 8.5 1.8 8.8 0.2 3.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper ARL6IP6 PF15062.6 EDP43546.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix SPG4 PF17325.2 EDP43546.1 - 0.24 12.5 0.9 0.81 10.8 0.9 1.9 1 0 0 1 1 1 0 Stationary phase protein 4 DUF5082 PF16888.5 EDP43546.1 - 0.28 11.4 9.9 0.042 14.1 2.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) LMBR1 PF04791.16 EDP43546.1 - 0.5 9.2 11.8 0.39 9.6 0.7 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein NPV_P10 PF05531.12 EDP43546.1 - 0.52 10.8 5.9 4.7 7.8 0.1 4.1 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EDP43546.1 - 3.7 7.7 11.7 0.44 10.7 0.4 3.3 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EDP43546.1 - 7.1 6.7 42.6 1.2 9.2 7.8 4.3 3 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EDP43546.1 - 7.2 5.4 31.6 2.2 7.1 12.2 2.7 2 2 0 2 2 2 0 Spc7 kinetochore protein CAP_N PF01213.19 EDP43547.1 - 1.4e-104 350.0 0.1 1.9e-104 349.6 0.1 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EDP43547.1 - 4.6e-56 188.8 0.1 6.4e-56 188.3 0.1 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EDP43547.1 - 0.0081 15.9 0.4 0.014 15.2 0.4 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C UCH PF00443.29 EDP43548.1 - 3.2e-43 148.1 0.0 4e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EDP43548.1 - 2.5e-19 69.4 4.9 2.5e-19 69.4 4.9 4.2 5 0 0 5 5 5 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EDP43548.1 - 3.2e-18 66.4 0.0 1.2e-16 61.2 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EDP43548.1 - 7.2e-16 57.7 0.2 1.1e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain RuvA_C PF07499.13 EDP43548.1 - 0.0019 18.6 0.1 0.41 11.2 0.0 2.6 2 0 0 2 2 2 1 RuvA, C-terminal domain zf-UBP_var PF17807.1 EDP43548.1 - 0.0024 17.6 1.8 0.58 10.0 0.0 2.8 2 0 0 2 2 2 2 Variant UBP zinc finger UBA_4 PF14555.6 EDP43548.1 - 0.027 14.3 2.2 0.2 11.5 1.0 2.3 2 0 0 2 2 2 0 UBA-like domain TF_Zn_Ribbon PF08271.12 EDP43548.1 - 0.15 11.6 4.6 1.2 8.8 0.5 3.1 2 0 0 2 2 2 0 TFIIB zinc-binding zf-C2HE PF16278.5 EDP43548.1 - 0.17 12.4 1.1 1.1 9.8 0.1 2.9 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Pex2_Pex12 PF04757.14 EDP43549.1 - 4.1e-45 154.1 3.9 4.9e-45 153.9 3.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EDP43549.1 - 0.0047 16.8 3.0 0.0073 16.1 3.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EDP43549.1 - 0.68 10.0 2.7 1.2 9.2 2.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4 PF00097.25 EDP43549.1 - 0.87 9.5 2.5 1.4 8.8 2.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP43549.1 - 0.92 9.7 5.9 1.6 8.9 5.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EDP43549.1 - 1.9 8.9 4.9 3.8 7.9 4.9 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EDP43549.1 - 4.7 7.1 6.1 12 5.9 6.1 1.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Thg1C PF14413.6 EDP43550.1 - 4.6e-41 139.8 0.2 1.7e-40 137.9 0.1 1.7 1 1 1 2 2 2 1 Thg1 C terminal domain Thg1 PF04446.12 EDP43550.1 - 2e-19 69.8 0.3 3e-19 69.3 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase XPA_C PF05181.12 EDP43551.1 - 0.2 11.7 0.3 0.33 11.0 0.3 1.3 1 0 0 1 1 1 0 XPA protein C-terminus STAG PF08514.11 EDP43553.1 - 9.5e-26 89.9 2.0 3e-25 88.3 2.0 1.9 1 0 0 1 1 1 1 STAG domain Cnd1 PF12717.7 EDP43553.1 - 0.00056 20.0 3.3 0.54 10.3 0.0 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.6 EDP43553.1 - 2.5 8.6 5.4 27 5.2 0.2 4.2 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain GCV_H PF01597.19 EDP43555.1 - 2e-31 108.4 0.2 2.5e-31 108.1 0.2 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 EDP43555.1 - 0.0018 18.2 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 EDP43555.1 - 0.0029 17.4 0.2 0.0048 16.7 0.2 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme eIF3g PF12353.8 EDP43555.1 - 0.11 12.9 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Lipase_3 PF01764.25 EDP43556.1 - 2.8e-08 33.7 0.0 4.7e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 EDP43556.1 - 0.024 14.4 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 EDP43556.1 - 0.027 15.1 1.4 0.039 14.5 0.1 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EDP43556.1 - 0.057 13.0 0.0 0.28 10.8 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold UPF0227 PF05728.12 EDP43556.1 - 0.083 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PC4 PF02229.16 EDP43557.1 - 0.054 13.1 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) MutL_C PF08676.11 EDP43557.1 - 0.094 12.5 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 MutL C terminal dimerisation domain WD40 PF00400.32 EDP43559.1 - 9.1e-31 105.4 19.5 0.00014 22.6 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43559.1 - 5.2e-09 36.3 0.0 0.26 11.6 0.0 5.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDP43559.1 - 5.1e-07 29.3 0.0 2.3e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 EDP43559.1 - 0.0035 16.4 0.9 5.5 5.8 0.0 3.7 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SGL PF08450.12 EDP43559.1 - 0.032 13.8 0.1 6.3 6.3 0.0 3.1 3 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Es2 PF09751.9 EDP43560.1 - 5.9e-56 191.0 21.1 5.9e-56 191.0 21.1 2.9 2 1 0 2 2 2 1 Nuclear protein Es2 Rsm22 PF09243.10 EDP43561.1 - 8.3e-32 110.5 0.1 2.6e-21 76.1 0.0 2.8 2 1 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 TraC_F_IV PF11130.8 EDP43561.1 - 0.0047 16.6 0.1 0.0096 15.6 0.1 1.5 1 0 0 1 1 1 1 F pilus assembly Type-IV secretion system for plasmid transfer Ima1_N PF09779.9 EDP43562.1 - 2.1e-23 83.6 1.2 1.3e-22 81.1 0.2 2.1 2 0 0 2 2 2 1 Ima1 N-terminal domain Cys_rich_KTR PF14205.6 EDP43562.1 - 0.022 14.6 0.2 7.1 6.5 0.0 2.7 2 0 0 2 2 2 0 Cysteine-rich KTR MerC PF03203.14 EDP43562.1 - 0.031 14.7 0.7 0.45 11.0 0.1 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein DUF1660 PF07874.11 EDP43562.1 - 0.48 11.0 2.1 2.9 8.5 0.1 2.7 2 1 1 3 3 3 0 Prophage protein (DUF1660) zinc_ribbon_10 PF10058.9 EDP43562.1 - 1.5 8.6 6.4 10 6.0 0.0 3.6 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 EDP43562.1 - 4.3 7.5 7.3 34 4.6 2.0 3.1 2 2 0 2 2 2 0 Double zinc ribbon Lyase_1 PF00206.20 EDP43563.1 - 3.3e-119 397.9 0.0 5.3e-119 397.2 0.0 1.3 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EDP43563.1 - 2.7e-18 66.1 0.1 6.2e-18 65.0 0.1 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus PhoU_div PF01865.16 EDP43563.1 - 0.08 12.3 0.0 0.23 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF47 RRM_1 PF00076.22 EDP43564.1 - 2.1e-06 27.5 0.0 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pescadillo_N PF06732.11 EDP43565.1 - 2.1e-119 398.1 0.1 4.4e-119 397.1 0.1 1.5 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 EDP43565.1 - 2.5e-05 24.6 0.0 7.3e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BUD22 PF09073.10 EDP43566.1 - 1.5e-45 156.4 30.2 2e-45 156.0 30.2 1.1 1 0 0 1 1 1 1 BUD22 Pyr_redox_2 PF07992.14 EDP43567.1 - 2.4e-09 36.8 0.0 7e-05 22.2 0.0 2.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDP43567.1 - 4.4e-09 36.0 0.0 5.3e-07 29.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EDP43567.1 - 2.1e-07 29.8 0.0 3.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EDP43567.1 - 3e-07 29.9 0.0 0.00027 20.2 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDP43567.1 - 5.8e-06 26.4 0.0 1.5e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDP43567.1 - 0.0021 18.6 0.0 1.6 9.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP43567.1 - 0.017 15.1 0.0 4.2 7.4 0.0 3.3 4 0 0 4 4 4 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EDP43567.1 - 0.039 13.0 0.0 2.7 6.9 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 EDP43567.1 - 0.051 13.1 0.1 0.33 10.5 0.0 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase Thioredoxin PF00085.20 EDP43568.1 - 2.4e-27 94.9 0.1 2.8e-27 94.7 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EDP43568.1 - 2.4e-06 27.9 0.1 3.9e-05 24.1 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EDP43568.1 - 1.9e-05 24.4 0.0 2.4e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EDP43568.1 - 0.00013 22.2 0.0 0.0039 17.5 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 EDP43568.1 - 0.00018 20.9 0.0 0.00019 20.9 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EDP43568.1 - 0.00037 20.4 0.0 0.00047 20.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDP43568.1 - 0.0026 17.5 0.3 0.014 15.1 0.2 1.9 1 1 1 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 EDP43568.1 - 0.019 15.1 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 EDP43568.1 - 0.035 14.1 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 EDP43568.1 - 0.098 12.3 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DIM1 PF02966.16 EDP43568.1 - 0.16 11.8 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 MTP18 PF10558.9 EDP43569.1 - 2e-54 184.1 7.8 3.6e-52 176.8 7.8 2.2 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ACPS PF01648.20 EDP43569.1 - 0.007 16.5 0.0 3.7 7.7 0.0 2.6 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily Exo_endo_phos PF03372.23 EDP43570.1 - 1.2e-07 31.5 0.0 6.1e-07 29.2 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ubie_methyltran PF01209.18 EDP43571.1 - 2e-69 233.5 0.0 7.8e-36 123.6 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EDP43571.1 - 3.1e-11 43.8 0.0 6.3e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDP43571.1 - 4.5e-09 36.8 0.0 5.2e-05 23.8 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43571.1 - 4e-08 33.9 0.0 7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP43571.1 - 1.5e-06 28.1 0.0 7.1e-06 25.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP43571.1 - 0.00015 21.6 0.0 0.00026 20.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Suc_Fer-like PF06999.12 EDP43572.1 - 3.6e-23 82.5 0.0 4.9e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Fer2 PF00111.27 EDP43572.1 - 6.2e-07 29.3 1.4 6.2e-07 29.3 1.4 2.5 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain SSB PF00436.25 EDP43573.1 - 1.1e-12 47.9 0.0 1.4e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Band_7 PF01145.25 EDP43575.1 - 3.3e-24 85.9 3.8 3.3e-24 85.9 3.8 2.0 1 1 1 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EDP43575.1 - 7.8e-05 21.9 3.2 0.0001 21.5 3.2 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial AAA_lid_4 PF17864.1 EDP43575.1 - 0.46 10.3 3.2 0.36 10.6 0.2 2.2 2 1 0 2 2 2 0 RuvB AAA lid domain Acetyltransf_3 PF13302.7 EDP43576.1 - 3.9e-10 40.5 0.0 5e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EDP43576.1 - 0.0013 18.4 0.0 0.13 11.9 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP43576.1 - 0.0028 17.9 0.0 0.54 10.5 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family FR47 PF08445.10 EDP43576.1 - 0.0042 17.0 0.0 0.15 12.1 0.0 2.1 2 0 0 2 2 2 1 FR47-like protein GNAT_acetyltran PF12746.7 EDP43576.1 - 0.032 13.8 0.0 0.31 10.6 0.0 2.1 1 1 1 2 2 2 0 GNAT acetyltransferase PriCT_1 PF08708.11 EDP43576.1 - 0.17 11.7 0.3 16 5.3 0.0 2.8 3 0 0 3 3 3 0 Primase C terminal 1 (PriCT-1) SWIB PF02201.18 EDP43577.1 - 3.4e-14 52.5 0.0 8.7e-14 51.2 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EDP43577.1 - 1.8e-08 34.2 1.0 4.3e-07 29.7 1.0 2.4 1 1 0 1 1 1 1 DEK C terminal domain ORC6 PF05460.13 EDP43577.1 - 0.0038 16.6 5.0 0.004 16.5 5.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Dicty_REP PF05086.12 EDP43577.1 - 0.0059 14.7 5.9 0.0074 14.3 5.9 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein PRTP PF01366.18 EDP43577.1 - 0.049 11.7 0.6 0.052 11.6 0.6 1.2 1 0 0 1 1 1 0 Herpesvirus processing and transport protein DUF913 PF06025.12 EDP43577.1 - 0.064 12.2 2.5 0.066 12.2 2.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NARP1 PF12569.8 EDP43577.1 - 0.071 12.0 4.6 0.092 11.6 4.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Tim54 PF11711.8 EDP43577.1 - 0.077 11.8 4.3 0.1 11.3 4.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 EDP43577.1 - 0.087 13.3 4.6 0.066 13.6 3.4 1.5 2 0 0 2 2 1 0 RNA polymerase III RPC4 PPP4R2 PF09184.11 EDP43577.1 - 0.088 12.4 15.8 0.01 15.4 11.4 1.6 2 0 0 2 2 2 0 PPP4R2 RP-C_C PF11800.8 EDP43577.1 - 0.09 12.9 3.9 0.13 12.4 3.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DIMCO_N PF16844.5 EDP43577.1 - 0.093 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal CDC45 PF02724.14 EDP43577.1 - 0.098 10.9 7.3 0.11 10.8 7.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 EDP43577.1 - 0.11 12.3 11.6 0.029 14.2 8.4 1.6 2 0 0 2 2 2 0 Coilin N-terminus Macoilin PF09726.9 EDP43577.1 - 0.12 11.0 9.5 0.13 10.8 9.5 1.1 1 0 0 1 1 1 0 Macoilin family Sec10 PF07393.11 EDP43577.1 - 0.12 10.8 4.6 0.14 10.5 4.6 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 Hid1 PF12722.7 EDP43577.1 - 0.17 10.0 4.2 0.18 9.9 4.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3438 PF11920.8 EDP43577.1 - 0.18 11.0 1.3 0.31 10.3 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Zip PF02535.22 EDP43577.1 - 0.25 10.5 2.9 0.29 10.3 2.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EDP43577.1 - 0.37 9.5 5.0 0.41 9.4 5.0 1.1 1 0 0 1 1 1 0 Presenilin DUF3449 PF11931.8 EDP43577.1 - 0.48 10.2 6.9 0.32 10.8 3.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Ndc1_Nup PF09531.10 EDP43577.1 - 0.52 8.9 4.2 0.6 8.7 4.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NPR3 PF03666.13 EDP43577.1 - 0.62 8.8 9.7 0.74 8.5 9.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 EDP43577.1 - 1.6 8.7 4.5 1.9 8.5 4.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3246 PF11596.8 EDP43577.1 - 2 7.8 8.7 0.09 12.2 3.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) RR_TM4-6 PF06459.12 EDP43577.1 - 2.6 7.8 10.7 1.9 8.2 9.9 1.3 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 CBFD_NFYB_HMF PF00808.23 EDP43578.1 - 1.6e-18 66.7 1.9 2.5e-18 66.1 1.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP43578.1 - 1.5e-13 51.3 0.3 3.4e-13 50.1 0.3 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.14 EDP43578.1 - 0.15 12.1 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Translin PF01997.16 EDP43579.1 - 2e-32 112.9 0.0 2.2e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Translin family BLOC1_2 PF10046.9 EDP43579.1 - 0.042 14.1 0.1 0.071 13.4 0.1 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EDP43579.1 - 0.081 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Septum formation initiator Abhydrolase_1 PF00561.20 EDP43580.1 - 1.7e-22 80.3 0.0 3.2e-22 79.4 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP43580.1 - 5.2e-22 79.5 1.9 9.4e-22 78.7 1.9 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP43580.1 - 2.4e-18 66.3 0.0 8.1e-18 64.6 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EDP43580.1 - 5.8e-06 26.3 0.0 0.00021 21.2 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Ndr PF03096.14 EDP43580.1 - 0.00024 19.9 0.0 0.00046 19.0 0.0 1.4 1 0 0 1 1 1 1 Ndr family BAAT_C PF08840.11 EDP43580.1 - 0.0003 20.8 0.0 0.27 11.1 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 EDP43580.1 - 0.00035 20.5 0.1 0.0015 18.4 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase Esterase PF00756.20 EDP43580.1 - 0.0005 19.8 0.0 0.0014 18.3 0.0 1.8 2 0 0 2 2 2 1 Putative esterase LIDHydrolase PF10230.9 EDP43580.1 - 0.00054 19.6 0.0 0.0024 17.5 0.0 1.9 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EDP43580.1 - 0.0031 17.0 0.0 0.23 10.9 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EDP43580.1 - 0.0053 16.6 0.0 8.1 6.2 0.0 3.1 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase UPF0227 PF05728.12 EDP43580.1 - 0.0079 16.2 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) DUF915 PF06028.11 EDP43580.1 - 0.011 15.1 0.0 0.043 13.1 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.18 EDP43580.1 - 0.017 14.7 0.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Lipase_3 PF01764.25 EDP43580.1 - 0.091 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase2 PF12740.7 EDP43580.1 - 0.092 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_5 PF12695.7 EDP43580.1 - 0.13 12.1 0.0 0.31 10.8 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EDP43580.1 - 0.16 12.1 0.6 4 7.5 0.3 2.8 2 1 0 2 2 2 0 Thioesterase domain PGAP1 PF07819.13 EDP43580.1 - 0.17 11.6 0.0 0.4 10.3 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein NPL4 PF05021.15 EDP43581.1 - 3.2e-92 309.2 0.0 4.2e-92 308.8 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EDP43581.1 - 5.1e-50 169.4 0.5 8e-50 168.8 0.5 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region Trep_dent_lipo PF09710.10 EDP43581.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Treponema clustered lipoprotein (Trep_dent_lipo) PPR_2 PF13041.6 EDP43582.1 - 0.032 14.4 0.0 1.7 8.9 0.0 2.9 3 0 0 3 3 3 0 PPR repeat family DUF3584 PF12128.8 EDP43583.1 - 0.023 12.2 14.0 0.033 11.7 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4201 PF13870.6 EDP43583.1 - 0.046 13.4 7.3 0.1 12.3 7.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 EDP43583.1 - 0.064 12.6 15.3 0.12 11.7 15.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CENP-H PF05837.12 EDP43583.1 - 0.084 13.3 19.4 0.19 12.1 4.4 2.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) SKA2 PF16740.5 EDP43583.1 - 0.33 10.8 9.3 1 9.2 6.1 2.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 YabA PF06156.13 EDP43583.1 - 0.35 11.5 5.1 0.26 11.9 2.3 2.3 1 1 0 1 1 1 0 Initiation control protein YabA V_ATPase_I PF01496.19 EDP43583.1 - 0.59 8.0 6.1 0.89 7.4 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_GP20 PF06810.11 EDP43583.1 - 0.68 9.7 8.6 1.4 8.7 8.6 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 Spc7 PF08317.11 EDP43583.1 - 0.74 8.6 15.4 1.4 7.7 15.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EDP43583.1 - 0.79 9.8 24.3 2 8.5 24.3 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EDP43583.1 - 0.79 10.2 21.4 0.11 13.0 6.3 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region HALZ PF02183.18 EDP43583.1 - 2.2 8.6 6.4 0.22 11.8 0.9 2.3 2 1 1 3 3 2 0 Homeobox associated leucine zipper CLZ PF16526.5 EDP43583.1 - 2.8 8.4 8.1 2.5 8.5 0.5 3.2 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fez1 PF06818.15 EDP43583.1 - 3.2 8.2 16.0 3.3 8.1 14.2 1.9 1 1 0 1 1 1 0 Fez1 TMF_TATA_bd PF12325.8 EDP43583.1 - 4.8 7.4 12.3 5.8 7.2 1.4 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 EDP43583.1 - 5.6 7.5 15.8 32 5.1 13.3 2.9 1 1 1 2 2 2 0 Cell division protein ZapB OmpH PF03938.14 EDP43583.1 - 5.7 7.3 18.3 3.9 7.8 13.9 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Prefoldin_2 PF01920.20 EDP43583.1 - 7.3 6.6 10.3 3.6 7.6 0.1 2.5 2 0 0 2 2 2 0 Prefoldin subunit FapA PF03961.13 EDP43583.1 - 9.6 4.7 5.3 14 4.1 5.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ras PF00071.22 EDP43584.1 - 3.4e-50 169.8 0.0 4.1e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP43584.1 - 5.8e-18 65.3 0.0 8.5e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP43584.1 - 7.7e-06 25.5 0.0 1e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ribosomal_L29 PF00831.23 EDP43586.1 - 2.9e-19 68.8 3.1 2.9e-19 68.8 3.1 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein DUF2680 PF10925.8 EDP43586.1 - 0.26 11.3 2.0 0.71 9.9 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) DUF1192 PF06698.11 EDP43586.1 - 5.2 7.2 6.5 1.6 8.8 0.8 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1192) SecE PF00584.20 EDP43587.1 - 9.4e-15 54.3 0.0 1.2e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Img2 PF05046.14 EDP43588.1 - 3.2e-22 78.6 0.0 4.5e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Cytochrom_B561 PF03188.16 EDP43589.1 - 5.9e-15 55.6 8.3 5.9e-15 55.6 8.3 1.7 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 COX5B PF01215.19 EDP43590.1 - 5.2e-38 129.6 0.0 6.2e-38 129.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb SH3_1 PF00018.28 EDP43591.1 - 4.9e-12 45.3 0.1 7.7e-12 44.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP43591.1 - 2.4e-10 40.1 0.0 3.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP43591.1 - 3e-09 36.4 0.0 6.1e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 EDP43591.1 - 0.0024 17.9 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 SH3 domain ERM PF00769.19 EDP43592.1 - 0.0017 18.2 3.3 0.0017 18.2 3.3 2.7 3 0 0 3 3 3 1 Ezrin/radixin/moesin family ADIP PF11559.8 EDP43592.1 - 0.058 13.5 0.8 0.15 12.1 0.8 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 EDP43592.1 - 0.15 12.7 0.4 0.42 11.3 0.4 1.8 1 0 0 1 1 1 0 Initiation control protein YabA UTP25 PF06862.12 EDP43593.1 - 3.4e-160 533.9 0.0 4e-160 533.7 0.0 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MMR_HSR1 PF01926.23 EDP43594.1 - 5.8e-16 58.6 0.1 4.2e-14 52.6 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDP43594.1 - 9.5e-08 32.1 0.1 0.00088 19.2 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EDP43594.1 - 1.3e-05 24.7 0.0 0.00013 21.5 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDP43594.1 - 0.0098 16.0 0.3 0.078 13.0 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.16 EDP43594.1 - 0.013 14.9 0.1 0.034 13.5 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Peptidase_S9_N PF02897.15 EDP43595.1 - 4.7e-84 282.6 0.2 6.3e-84 282.2 0.2 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Fcf1 PF04900.12 EDP43595.1 - 0.16 12.4 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 Fcf1 Peptidase_S9 PF00326.21 EDP43596.1 - 3.7e-23 82.1 0.0 3.9e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Pre-PUA PF17832.1 EDP43597.1 - 1.5e-21 76.9 0.1 2.3e-21 76.3 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EDP43597.1 - 3.1e-16 59.1 0.0 4.4e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 PUA domain Peptidase_C12 PF01088.21 EDP43599.1 - 4.8e-56 189.8 0.0 5.7e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UDG PF03167.19 EDP43600.1 - 4.5e-07 30.0 0.0 1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily PT PF04886.12 EDP43600.1 - 0.014 14.9 21.8 0.047 13.2 21.3 2.3 1 1 0 1 1 1 0 PT repeat Hid1 PF12722.7 EDP43600.1 - 0.66 8.0 6.1 0.78 7.8 6.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4106 PF13388.6 EDP43600.1 - 2.4 7.3 6.9 3.4 6.8 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Ndc1_Nup PF09531.10 EDP43600.1 - 4.7 5.8 7.2 4.5 5.9 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1387 PF07139.11 EDP43600.1 - 9.4 5.9 8.3 13 5.4 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Pro_CA PF00484.19 EDP43601.1 - 5.9e-38 130.6 0.1 8.5e-38 130.1 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase ADH_zinc_N PF00107.26 EDP43603.1 - 7.1e-14 51.9 0.2 1.1e-13 51.3 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Oxidored_nitro PF00148.19 EDP43603.1 - 0.00076 18.3 0.0 0.00095 18.0 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase 2-Hacid_dh_C PF02826.19 EDP43603.1 - 0.015 14.7 0.8 0.038 13.4 0.5 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PCMT PF01135.19 EDP43603.1 - 0.048 13.4 0.0 0.059 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Polyketide_cyc PF03364.20 EDP43604.1 - 2.7e-25 89.1 0.1 3.5e-25 88.7 0.1 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Prenyltransf PF01255.19 EDP43605.1 - 1.3e-69 234.1 0.0 1.6e-69 233.9 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PRMT5_TIM PF17285.2 EDP43605.1 - 0.051 12.8 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 PRMT5 TIM barrel domain DUF3844 PF12955.7 EDP43606.1 - 3.9e-24 84.8 1.9 6.6e-24 84.1 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Mito_carr PF00153.27 EDP43607.1 - 6.2e-31 106.2 0.5 3.3e-14 52.6 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Iso_dh PF00180.20 EDP43608.1 - 3.7e-67 226.9 0.0 4.5e-67 226.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF5064 PF16703.5 EDP43608.1 - 0.095 13.2 0.2 0.33 11.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5064) Glyco_hydro_88 PF07470.13 EDP43609.1 - 1.7e-17 63.5 1.0 4e-17 62.3 0.4 1.9 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 AMP-binding PF00501.28 EDP43609.1 - 0.0028 16.3 0.0 0.0054 15.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme DUF4350 PF14258.6 EDP43609.1 - 0.27 11.7 1.1 12 6.5 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4350) Rit1_C PF17184.4 EDP43610.1 - 9.9e-52 176.1 0.0 4.3e-51 173.9 0.0 2.1 3 1 0 3 3 3 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EDP43610.1 - 1.1e-20 73.9 0.0 2.2e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Rotamase PF00639.21 EDP43611.1 - 1.3e-22 80.5 0.0 1.7e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EDP43611.1 - 1.6e-19 70.5 0.0 2.1e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EDP43611.1 - 6.8e-06 26.1 0.0 1.4e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 EDP43611.1 - 0.00016 22.5 0.0 0.00022 22.1 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain CMAS PF02353.20 EDP43613.1 - 4.7e-64 216.3 0.0 6.7e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EDP43613.1 - 7.7e-15 55.4 0.0 4e-14 53.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP43613.1 - 2.1e-13 50.4 0.0 4.2e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP43613.1 - 2.7e-13 50.4 0.0 3.9e-12 46.6 0.0 2.8 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP43613.1 - 3.7e-08 33.3 0.0 1.1e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43613.1 - 3.6e-07 30.9 0.0 1.4e-06 29.0 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDP43613.1 - 4.4e-06 26.3 0.0 8.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Apolipoprotein PF01442.18 EDP43613.1 - 0.00036 20.5 10.2 0.00056 19.8 10.2 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain PCMT PF01135.19 EDP43613.1 - 0.00042 20.1 0.0 0.00086 19.1 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 EDP43613.1 - 0.0012 18.4 0.0 0.0079 15.7 0.0 2.1 2 0 0 2 2 2 1 Histone methylation protein DOT1 PrmA PF06325.13 EDP43613.1 - 0.009 15.4 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EDP43613.1 - 0.023 14.7 4.1 0.11 12.5 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Syntaxin_2 PF14523.6 EDP43613.1 - 0.093 13.1 2.2 0.18 12.2 2.2 1.4 1 0 0 1 1 1 0 Syntaxin-like protein MetW PF07021.12 EDP43613.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RrnaAD PF00398.20 EDP43613.1 - 0.15 11.1 0.1 0.42 9.6 0.0 1.7 3 0 0 3 3 3 0 Ribosomal RNA adenine dimethylase YtxH PF12732.7 EDP43613.1 - 0.36 11.4 8.0 20 5.8 8.0 2.4 1 1 0 1 1 1 0 YtxH-like protein YABBY PF04690.13 EDP43613.1 - 4.7 7.8 5.5 32 5.0 6.7 1.8 2 0 0 2 2 1 0 YABBY protein Gtr1_RagA PF04670.12 EDP43615.1 - 1.7e-48 165.0 0.4 3e-48 164.2 0.4 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF1640 PF07798.11 EDP43616.1 - 6.6e-59 198.9 5.9 7.5e-59 198.7 5.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.18 EDP43616.1 - 0.042 14.1 3.1 0.22 11.8 3.1 2.0 1 1 0 1 1 1 0 Homeobox associated leucine zipper CCDC23 PF15674.5 EDP43616.1 - 0.96 9.5 2.9 1.2 9.2 0.6 2.4 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 23 GreA_GreB_N PF03449.15 EDP43616.1 - 1 9.6 5.0 0.34 11.1 1.5 2.0 2 1 0 2 2 2 0 Transcription elongation factor, N-terminal PNP_phzG_C PF10590.9 EDP43617.1 - 9.3e-11 41.6 0.5 1.7e-10 40.8 0.5 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EDP43617.1 - 0.015 15.5 0.0 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase HlyIII PF03006.20 EDP43618.1 - 1.7e-51 175.1 11.6 2.1e-51 174.8 11.6 1.2 1 0 0 1 1 1 1 Haemolysin-III related Ndr PF03096.14 EDP43618.1 - 0.0066 15.2 0.0 0.009 14.7 0.0 1.1 1 0 0 1 1 1 1 Ndr family UPF0060 PF02694.15 EDP43618.1 - 0.18 12.0 9.2 0.66 10.2 2.8 3.0 1 1 1 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family Rep_fac_C PF08542.11 EDP43619.1 - 2.3e-26 92.0 0.0 8e-26 90.3 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 EDP43619.1 - 4e-12 46.7 0.0 6.9e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EDP43619.1 - 2e-11 43.9 0.0 9.3e-10 38.5 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 EDP43619.1 - 6.4e-07 29.9 0.0 6.4e-05 23.4 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EDP43619.1 - 1.7e-05 24.9 0.0 2.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EDP43619.1 - 2.2e-05 24.3 0.0 4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EDP43619.1 - 8.1e-05 22.9 0.0 0.065 13.5 0.0 2.6 2 1 1 3 3 2 2 AAA domain RuvB_N PF05496.12 EDP43619.1 - 0.00079 19.2 0.0 0.0018 18.0 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EDP43619.1 - 0.0026 17.7 0.0 0.0055 16.6 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EDP43619.1 - 0.0035 16.7 0.1 0.042 13.2 0.1 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDP43619.1 - 0.0037 17.3 0.0 0.016 15.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MeaB PF03308.16 EDP43619.1 - 0.0071 15.4 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EDP43619.1 - 0.0075 16.0 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EDP43619.1 - 0.042 13.6 0.0 0.094 12.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_assoc_2 PF16193.5 EDP43619.1 - 0.063 13.6 0.0 0.19 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA C-terminal domain SRP54 PF00448.22 EDP43619.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EDP43619.1 - 0.13 12.6 0.0 0.97 9.8 0.0 2.1 1 1 1 2 2 2 0 AAA domain NTPase_1 PF03266.15 EDP43619.1 - 0.15 11.9 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 EDP43619.1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Sec8_exocyst PF04048.14 EDP43620.1 - 6.7 6.6 20.7 3.6 7.5 6.3 3.5 2 1 0 3 3 3 0 Sec8 exocyst complex component specific domain Kelch_4 PF13418.6 EDP43621.1 - 3.6e-34 116.5 12.5 9.2e-08 32.0 0.2 6.8 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EDP43621.1 - 5e-34 115.7 5.0 2.7e-07 30.4 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EDP43621.1 - 3.6e-33 113.2 11.1 3.9e-09 36.6 0.1 8.0 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EDP43621.1 - 3.6e-30 103.2 6.1 2.9e-10 40.0 0.2 6.6 4 1 2 6 6 6 6 Kelch motif Kelch_1 PF01344.25 EDP43621.1 - 3.6e-22 77.7 12.1 8.6e-09 34.8 0.4 6.1 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.15 EDP43621.1 - 7.7e-22 76.4 9.3 3.3e-05 23.7 0.2 6.8 6 1 0 6 6 6 5 Kelch motif Protamine_P2 PF00841.19 EDP43621.1 - 0.59 10.7 5.1 2.1 8.9 5.1 1.9 1 0 0 1 1 1 0 Sperm histone P2 zf-C2H2_4 PF13894.6 EDP43623.1 - 0.058 14.2 2.6 0.16 12.9 2.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-BED PF02892.15 EDP43623.1 - 0.067 13.2 0.5 0.12 12.4 0.5 1.4 1 0 0 1 1 1 0 BED zinc finger Zn_Tnp_IS1595 PF12760.7 EDP43623.1 - 0.067 13.2 0.3 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF4470 PF14737.6 EDP43624.1 - 3.4e-05 23.9 0.0 0.00021 21.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4470) Methyltransf_31 PF13847.6 EDP43624.1 - 0.00012 21.9 0.0 0.011 15.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP43624.1 - 0.0026 18.5 0.1 0.011 16.4 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain Rhodanese PF00581.20 EDP43624.1 - 0.0069 16.9 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_11 PF08241.12 EDP43624.1 - 0.033 14.8 0.1 0.24 12.1 0.1 2.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43624.1 - 0.12 13.1 0.0 0.34 11.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain CN_hydrolase PF00795.22 EDP43625.1 - 2e-35 122.4 0.0 3e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EDP43625.1 - 5.9e-26 91.0 0.0 1.9e-25 89.4 0.0 1.7 1 1 0 1 1 1 1 NAD synthase adh_short PF00106.25 EDP43626.1 - 6.1e-36 123.7 0.1 7.7e-36 123.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP43626.1 - 1.4e-19 70.6 0.0 1.8e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP43626.1 - 3.9e-05 23.7 0.1 6.8e-05 22.9 0.1 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EDP43626.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Dcc1 PF09724.9 EDP43626.1 - 0.0059 16.0 0.0 0.0083 15.5 0.0 1.2 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Polysacc_synt_2 PF02719.15 EDP43626.1 - 0.046 12.9 0.1 0.061 12.5 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein FixP_N PF14715.6 EDP43626.1 - 3.7 7.4 5.6 8.4 6.2 0.9 2.4 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Usp PF00582.26 EDP43628.1 - 7.5e-06 26.5 0.0 1.2e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family Glyco_transf_20 PF00982.21 EDP43629.1 - 6.2e-181 602.2 0.0 5.7e-136 453.9 0.0 2.0 2 0 0 2 2 2 2 Glycosyltransferase family 20 Arginosuc_synth PF00764.19 EDP43630.1 - 1.9e-158 527.8 0.0 2.3e-158 527.6 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EDP43630.1 - 0.00092 18.8 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EDP43630.1 - 0.026 13.3 0.0 0.038 12.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase PUF PF00806.19 EDP43631.1 - 6.3e-08 31.9 0.0 0.0003 20.3 0.0 4.4 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat TTL PF03133.15 EDP43632.1 - 1.7e-37 129.2 0.0 8e-37 126.9 0.0 1.9 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family Sec7 PF01369.20 EDP43633.1 - 1.4e-24 86.8 0.0 2.7e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain zf-C2H2 PF00096.26 EDP43634.1 - 5.6e-20 70.6 41.8 0.00024 21.4 2.5 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP43634.1 - 3.6e-16 58.4 41.2 0.004 17.9 2.0 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP43634.1 - 5.4e-05 23.4 0.0 5.4e-05 23.4 0.0 7.5 8 1 0 8 8 8 3 Zinc-finger double domain zf-met PF12874.7 EDP43634.1 - 0.0068 16.8 9.3 0.11 13.0 0.1 5.4 5 1 0 5 5 5 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EDP43634.1 - 0.0088 16.3 10.3 0.21 11.9 0.8 3.2 2 1 1 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EDP43634.1 - 0.014 15.7 0.6 3.2 8.1 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding BolA PF01722.18 EDP43634.1 - 0.016 15.5 0.5 13 6.1 0.0 3.3 3 0 0 3 3 3 0 BolA-like protein FYDLN_acid PF09538.10 EDP43634.1 - 0.067 13.9 1.4 0.76 10.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) FOXP-CC PF16159.5 EDP43634.1 - 0.068 13.8 15.9 0.38 11.4 1.9 4.9 4 2 1 5 5 5 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EDP43634.1 - 0.12 12.1 22.6 0.58 10.0 0.4 4.6 5 0 0 5 5 5 0 zinc-finger C2H2-type zf_ZIC PF18366.1 EDP43634.1 - 0.15 12.2 3.2 2.5 8.3 0.1 3.6 3 1 0 3 3 3 0 Zic proteins zinc finger domain IBR PF01485.21 EDP43634.1 - 4.2 7.7 16.7 0.92 9.8 0.2 3.7 4 0 0 4 4 4 0 IBR domain, a half RING-finger domain zf-C2H2_6 PF13912.6 EDP43634.1 - 4.6 7.4 14.9 2 8.5 0.8 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EDP43634.1 - 6.8 6.8 12.9 4.6 7.4 3.9 2.9 2 1 0 2 2 2 0 Aberrant zinc-finger RRM_1 PF00076.22 EDP43635.1 - 2.8e-33 113.6 0.0 8.4e-20 70.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EDP43635.1 - 3.7e-07 31.1 0.5 6.8e-05 23.9 0.5 2.7 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EDP43635.1 - 0.00064 19.5 0.0 0.0043 16.9 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EDP43635.1 - 0.0016 18.4 0.1 0.16 12.0 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif RRM_8 PF11835.8 EDP43635.1 - 0.0027 17.9 0.1 2 8.7 0.0 2.4 2 0 0 2 2 2 2 RRM-like domain RRM_5 PF13893.6 EDP43635.1 - 0.0068 16.0 0.0 0.23 11.1 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP43635.1 - 0.036 14.1 0.1 4.1 7.5 0.1 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif YXWGXW PF12779.7 EDP43635.1 - 1.2 9.3 3.7 0.85 9.8 0.5 2.3 2 0 0 2 2 2 0 YXWGXW repeat (2 copies) ANAPC4_WD40 PF12894.7 EDP43636.1 - 7.7e-08 32.5 0.8 0.0036 17.6 0.0 4.9 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EDP43636.1 - 0.011 15.7 2.5 1.8 8.6 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 EDP43636.1 - 0.029 15.2 15.5 0.03 15.2 0.3 5.7 7 0 0 7 7 7 0 WD domain, G-beta repeat Glycos_transf_1 PF00534.20 EDP43637.1 - 4.3e-33 114.3 0.0 1.4e-32 112.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDP43637.1 - 5.1e-24 85.2 0.0 1.2e-23 84.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDP43637.1 - 1.9e-05 24.7 0.0 4.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EDP43637.1 - 0.077 13.4 2.7 1.3 9.4 0.0 3.2 3 1 0 3 3 3 0 Glycosyl transferases group 1 BING4CT PF08149.11 EDP43638.1 - 3.5e-38 129.3 0.0 2e-36 123.7 0.0 3.2 3 0 0 3 3 3 1 BING4CT (NUC141) domain Coatomer_WDAD PF04053.14 EDP43638.1 - 4.5e-06 26.0 0.0 6.4e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EDP43638.1 - 1.2e-05 25.9 0.1 0.001 19.9 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat ABC_tran PF00005.27 EDP43639.1 - 9.1e-15 55.4 0.0 1.7e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EDP43639.1 - 1.1e-09 38.6 0.8 0.00067 19.5 0.5 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP43639.1 - 0.00086 19.0 0.0 0.0019 17.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EDP43639.1 - 0.0043 17.5 0.0 0.0091 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EDP43639.1 - 0.0071 16.6 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDP43639.1 - 0.0072 15.9 0.0 0.0098 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EDP43639.1 - 0.01 15.3 0.0 3.3 7.1 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EDP43639.1 - 0.013 15.3 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein UBM PF14377.6 EDP43639.1 - 0.015 14.8 0.1 0.039 13.4 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin binding region RsgA_GTPase PF03193.16 EDP43639.1 - 0.046 13.6 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 EDP43639.1 - 0.048 13.8 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EDP43639.1 - 0.073 13.6 0.1 0.12 12.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EDP43639.1 - 0.092 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_33 PF13671.6 EDP43639.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDP43639.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EDP43639.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EDP43639.1 - 0.2 11.7 0.1 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EDP43639.1 - 0.21 10.8 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Metallophos PF00149.28 EDP43640.1 - 5e-36 125.1 0.0 8.6e-36 124.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDP43640.1 - 1.6e-15 57.2 0.0 2.9e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PRK PF00485.18 EDP43641.1 - 2.6e-49 167.7 0.0 3.6e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EDP43641.1 - 4.6e-41 140.5 0.0 2.5e-38 131.6 0.0 2.2 2 0 0 2 2 2 2 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EDP43641.1 - 0.00029 21.4 0.0 0.0006 20.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EDP43641.1 - 0.0021 17.9 0.0 0.004 17.0 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EDP43641.1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDP43641.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.20 EDP43641.1 - 0.12 12.0 0.6 1.6 8.3 1.6 2.3 2 1 0 2 2 2 0 Dephospho-CoA kinase DUF2985 PF11204.8 EDP43642.1 - 2.3e-25 88.5 6.0 3.8e-25 87.8 6.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Molybdopterin PF00384.22 EDP43643.1 - 1.9e-68 231.4 0.0 1.3e-65 222.1 0.0 2.7 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EDP43643.1 - 9.8e-17 60.8 0.0 2.4e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 EDP43643.1 - 6.2e-16 57.6 0.1 6.2e-16 57.6 0.1 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 EDP43643.1 - 4.8e-15 56.0 0.2 1.3e-14 54.6 0.2 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 EDP43643.1 - 3e-09 36.7 0.4 7.2e-09 35.5 0.4 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 EDP43643.1 - 0.004 16.9 0.2 0.17 11.6 0.1 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EDP43643.1 - 0.21 11.5 1.7 8.3 6.4 0.6 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Arf PF00025.21 EDP43644.1 - 1.9e-18 66.5 0.1 6.5e-18 64.8 0.1 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP43644.1 - 6.2e-08 32.9 0.0 1.8e-07 31.4 0.0 1.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EDP43644.1 - 2.4e-05 23.7 0.0 0.063 12.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDP43644.1 - 0.00018 21.0 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EDP43644.1 - 0.00079 19.7 0.0 0.0033 17.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EDP43644.1 - 0.003 17.0 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EDP43644.1 - 0.0035 17.8 0.1 0.018 15.5 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EDP43644.1 - 0.027 14.5 0.0 0.059 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 EDP43644.1 - 0.037 13.6 0.0 0.059 13.0 0.0 1.5 1 1 0 1 1 1 0 Ras family MMR_HSR1 PF01926.23 EDP43644.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase ICE2 PF08426.10 EDP43645.1 - 6.1e-26 91.5 0.8 1.4e-25 90.3 0.8 1.6 1 1 0 1 1 1 1 ICE2 RRS1 PF04939.12 EDP43646.1 - 1.9e-56 190.4 5.2 3e-56 189.8 5.2 1.3 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) WD40 PF00400.32 EDP43647.1 - 8.7e-32 108.7 13.4 1.6e-08 35.0 0.2 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43647.1 - 1.1e-11 44.9 0.0 0.0026 18.0 0.0 5.0 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDP43647.1 - 0.00018 20.2 0.0 0.064 11.8 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain PQQ_2 PF13360.6 EDP43647.1 - 0.0011 18.7 0.9 0.31 10.6 0.0 3.6 3 1 1 4 4 4 2 PQQ-like domain Ge1_WD40 PF16529.5 EDP43647.1 - 0.0017 17.4 0.2 0.72 8.8 0.0 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EDP43647.1 - 0.035 14.1 0.1 0.23 11.5 0.1 2.4 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EDP43647.1 - 0.084 12.2 0.0 0.67 9.2 0.0 2.0 2 0 0 2 2 2 0 WD40-like domain DUF501 PF04417.12 EDP43647.1 - 0.14 11.9 0.1 4 7.2 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF501) Ribul_P_3_epim PF00834.19 EDP43648.1 - 1.3e-62 210.7 0.0 1.6e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family PG_binding_3 PF09374.10 EDP43648.1 - 0.01 16.0 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 Predicted Peptidoglycan domain QRPTase_C PF01729.19 EDP43648.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Peptidase_A22B PF04258.13 EDP43649.1 - 8.8e-70 235.4 7.7 1.2e-69 235.0 7.7 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EDP43649.1 - 0.00024 20.7 7.7 0.00063 19.3 4.8 2.2 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease HILPDA PF15220.6 EDP43649.1 - 5.1 7.3 6.5 1.4 9.1 0.8 2.7 3 0 0 3 3 3 0 Hypoxia-inducible lipid droplet-associated MIF4G PF02854.19 EDP43650.1 - 1.6e-19 70.4 0.1 2.8e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 EDP43650.1 - 3.2e-07 30.3 0.1 1.2e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 MA3 domain CDV3 PF15359.6 EDP43650.1 - 0.028 14.9 7.9 0.062 13.8 7.9 1.5 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 Sigma70_ner PF04546.13 EDP43650.1 - 0.62 9.9 14.5 0.12 12.3 9.9 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region TRAP_alpha PF03896.16 EDP43650.1 - 1.8 7.7 6.5 3.7 6.7 6.5 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 EDP43650.1 - 3.6 6.9 21.9 6.4 6.1 21.9 1.4 1 0 0 1 1 1 0 SDA1 DEAD PF00270.29 EDP43651.1 - 3.7e-40 137.5 0.1 6.3e-40 136.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43651.1 - 1.4e-31 109.1 0.3 3.3e-29 101.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43651.1 - 2.8e-09 37.2 0.0 4.8e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EDP43651.1 - 0.00019 21.2 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 EDP43651.1 - 0.0016 18.7 0.1 0.0044 17.3 0.1 1.8 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EDP43651.1 - 0.0021 17.9 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 Helicase AAA_19 PF13245.6 EDP43651.1 - 0.0026 18.1 0.1 0.0057 17.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 EDP43651.1 - 0.0039 16.0 0.1 1.6 7.4 0.2 2.4 2 1 1 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 T4SS-DNA_transf PF02534.14 EDP43651.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Spc7 PF08317.11 EDP43652.1 - 6.5e-48 163.2 3.1 1.1e-47 162.5 3.1 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein KxDL PF10241.9 EDP43652.1 - 1.1 9.6 5.8 1.9 8.8 1.3 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein Atg14 PF10186.9 EDP43652.1 - 3.8 6.5 6.5 6.3 5.8 4.9 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Dus PF01207.17 EDP43653.1 - 4.1e-33 114.8 0.1 5.6e-33 114.3 0.1 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Atypical_Card PF18461.1 EDP43653.1 - 0.0096 16.1 0.0 0.031 14.5 0.0 1.8 1 1 0 1 1 1 1 Atypical caspase recruitment domain PapG_C PF03628.13 EDP43653.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 PapG chaperone-binding domain Rad60-SLD_2 PF13881.6 EDP43654.1 - 0.00081 19.5 0.0 0.0022 18.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDP43654.1 - 0.023 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family CCDC53 PF10152.9 EDP43654.1 - 0.27 11.6 3.9 11 6.4 0.0 3.2 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex VPS28 PF03997.12 EDP43655.1 - 5.1e-47 160.0 0.0 5.9e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 VPS28 protein Proteasome PF00227.26 EDP43658.1 - 1.8e-44 151.5 0.0 2.3e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDP43658.1 - 2.6e-13 49.4 0.3 4.7e-13 48.6 0.3 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature MSC PF09402.10 EDP43660.1 - 1.2e-74 251.8 0.6 1.9e-74 251.1 0.5 1.4 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EDP43660.1 - 2.9e-14 52.5 0.0 6e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain EGF_Tenascin PF18720.1 EDP43660.1 - 1.2 9.3 3.1 3.2 7.9 3.1 1.7 1 0 0 1 1 1 0 Tenascin EGF domain DHHC PF01529.20 EDP43661.1 - 3e-29 101.8 12.4 4.7e-29 101.2 12.4 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF898 PF05987.13 EDP43661.1 - 0.0013 17.9 0.7 0.0021 17.2 0.7 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) Imm58 PF15581.6 EDP43661.1 - 0.009 16.1 0.0 0.89 9.7 0.1 3.0 3 0 0 3 3 3 1 Immunity protein 58 RIO1 PF01163.22 EDP43662.1 - 2.6e-40 138.0 0.3 4.5e-27 94.9 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 EDP43662.1 - 1.6e-32 111.5 0.1 3.9e-32 110.3 0.1 1.7 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EDP43662.1 - 1.8e-07 31.3 0.6 0.00096 19.1 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDP43662.1 - 2.7e-05 23.6 0.2 0.00074 18.9 0.2 2.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MarR_2 PF12802.7 EDP43662.1 - 0.033 14.1 0.1 0.24 11.3 0.0 2.2 2 0 0 2 2 2 0 MarR family CENP-O PF09496.10 EDP43662.1 - 0.041 13.8 1.9 0.45 10.5 0.3 2.4 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component E1_DerP2_DerF2 PF02221.15 EDP43663.1 - 3.3e-18 66.4 0.0 4.1e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EDP43663.1 - 4.1e-05 24.0 0.0 9.6e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 ML-like domain Mre11_DNA_bind PF04152.14 EDP43664.1 - 6.4e-39 134.0 0.2 1.2e-38 133.1 0.2 1.4 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EDP43664.1 - 1.7e-07 31.9 0.0 3.7e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDP43664.1 - 0.0054 16.9 0.0 0.026 14.7 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Rcd1 PF04078.13 EDP43665.1 - 2.1e-123 410.7 1.2 2.7e-123 410.4 1.2 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like cwf21 PF08312.12 EDP43666.1 - 2.1e-15 56.6 5.9 2.1e-15 56.6 5.9 2.1 2 0 0 2 2 2 1 cwf21 domain Pex14_N PF04695.13 EDP43666.1 - 6.4 7.4 9.2 0.63 10.7 1.6 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PMM PF03332.13 EDP43667.1 - 1.6e-103 345.3 0.3 1.8e-103 345.1 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EDP43667.1 - 2.7e-05 24.1 0.0 0.00041 20.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EDP43667.1 - 0.0046 16.5 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EDP43667.1 - 0.062 13.6 0.0 0.18 12.0 0.0 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF600 PF04634.12 EDP43667.1 - 0.097 12.7 0.7 0.54 10.3 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function, DUF600 PPR_2 PF13041.6 EDP43670.1 - 6.4e-34 115.9 0.3 1.3e-07 31.7 0.0 8.6 8 1 1 9 9 9 7 PPR repeat family PPR PF01535.20 EDP43670.1 - 4.2e-18 64.2 0.1 3e-05 23.9 0.0 6.3 7 0 0 7 7 7 3 PPR repeat PPR_1 PF12854.7 EDP43670.1 - 3.4e-17 61.8 0.1 0.0011 18.7 0.0 5.4 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 EDP43670.1 - 9.2e-14 51.3 0.2 1.6e-05 24.9 0.0 4.2 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EDP43670.1 - 2.9e-05 23.5 0.3 0.053 12.9 0.0 2.4 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EDP43670.1 - 0.073 13.5 0.0 42 4.6 0.0 4.0 3 1 2 5 5 5 0 Mitochondrial ribonuclease P subunit (RPM2) CDT1_C PF16679.5 EDP43670.1 - 4.1 7.9 5.4 4.6 7.7 1.2 3.0 2 1 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Acetyltransf_10 PF13673.7 EDP43671.1 - 9.4e-09 35.3 0.1 2.5e-07 30.7 0.1 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDP43671.1 - 3.7e-08 33.7 0.0 7.2e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP43671.1 - 0.00018 21.7 0.0 0.00065 19.9 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 EDP43671.1 - 0.0012 19.5 0.1 0.012 16.3 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDP43671.1 - 0.11 12.5 0.3 1.3 9.1 0.3 2.2 1 1 0 1 1 1 0 FR47-like protein CHCH PF06747.13 EDP43672.1 - 0.01 15.9 0.4 0.015 15.4 0.4 1.3 1 0 0 1 1 1 0 CHCH domain GCK PF07802.11 EDP43672.1 - 0.038 14.4 0.4 0.053 14.0 0.4 1.2 1 0 0 1 1 1 0 GCK domain Sec61_beta PF03911.16 EDP43673.1 - 4.4e-15 55.4 0.1 6.3e-15 54.9 0.1 1.3 1 0 0 1 1 1 1 Sec61beta family DUF4407 PF14362.6 EDP43673.1 - 0.012 14.9 0.1 0.014 14.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1180 PF06679.12 EDP43673.1 - 0.02 15.3 1.4 0.023 15.1 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Baculo_11_kDa PF06143.11 EDP43673.1 - 0.3 10.7 2.9 2.1 8.0 0.1 2.2 2 0 0 2 2 2 0 Baculovirus 11 kDa family Svf1_C PF17187.4 EDP43674.1 - 1.2e-48 165.0 0.0 1.9e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EDP43674.1 - 2.6e-28 99.1 0.1 4.5e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Hus1 PF04005.12 EDP43675.1 - 4.8e-50 170.3 0.4 5.8e-50 170.1 0.4 1.0 1 0 0 1 1 1 1 Hus1-like protein Clathrin-link PF09268.10 EDP43676.1 - 0.23 10.9 0.9 0.48 9.8 0.9 1.6 1 0 0 1 1 1 0 Clathrin, heavy-chain linker Yae1_N PF09811.9 EDP43677.1 - 9.6e-08 31.6 11.9 1.3e-07 31.1 11.9 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal DUF2730 PF10805.8 EDP43677.1 - 0.025 14.6 0.1 0.039 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Cation_efflux PF01545.21 EDP43678.1 - 2.1e-32 112.5 6.8 2.6e-32 112.2 6.8 1.1 1 0 0 1 1 1 1 Cation efflux family CENP-X PF09415.10 EDP43678.1 - 0.1 12.9 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X ESSS PF10183.9 EDP43679.1 - 0.0026 17.9 0.2 0.0027 17.9 0.2 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) PH PF00169.29 EDP43680.1 - 3.6e-27 94.9 0.6 4.7e-13 49.5 0.2 3.5 3 0 0 3 3 3 3 PH domain PH_3 PF14593.6 EDP43680.1 - 1.3e-09 38.1 0.6 0.0017 18.5 0.1 3.2 3 0 0 3 3 3 3 PH domain PH_8 PF15409.6 EDP43680.1 - 5.2e-09 36.3 2.8 3e-06 27.4 0.8 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EDP43680.1 - 8.5e-09 35.8 13.4 0.0023 18.3 5.5 4.1 2 2 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 EDP43680.1 - 6.1e-05 23.1 2.5 0.02 15.0 0.5 2.7 2 1 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_2 PF08458.10 EDP43680.1 - 0.00069 19.9 1.1 0.47 10.8 0.7 2.4 2 0 0 2 2 2 2 Plant pleckstrin homology-like region PH_17 PF18012.1 EDP43680.1 - 0.067 12.9 0.2 0.23 11.2 0.1 2.0 2 0 0 2 2 2 0 PH domain PH_9 PF15410.6 EDP43680.1 - 1.2 9.5 4.3 2.9 8.3 1.7 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain SAM_decarbox PF01536.16 EDP43681.1 - 0.02 13.9 0.1 0.028 13.4 0.1 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Pirin_C_2 PF17954.1 EDP43681.1 - 0.083 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain zf-CCCH PF00642.24 EDP43682.1 - 5.5e-11 42.1 26.2 0.00054 19.8 0.7 4.2 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP43682.1 - 6.2e-10 38.8 25.5 1.3e-05 25.1 1.9 4.1 4 0 0 4 4 4 3 Zinc finger domain Torus PF16131.5 EDP43682.1 - 3.4e-09 37.3 14.9 0.00041 21.0 0.2 3.8 1 1 3 4 4 4 3 Torus domain zf-CCCH_4 PF18044.1 EDP43682.1 - 2.1e-07 30.6 13.4 4.9e-05 23.0 0.5 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EDP43682.1 - 0.53 10.5 15.3 0.8 10.0 4.7 3.0 1 1 1 2 2 2 0 Zinc-finger containing family ShK PF01549.24 EDP43682.1 - 3.7 8.2 7.3 0.62 10.6 0.5 2.9 2 1 1 3 3 3 0 ShK domain-like zf-CCCH_2 PF14608.6 EDP43682.1 - 4 8.1 18.3 0.18 12.3 1.7 3.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger HECT PF00632.25 EDP43683.1 - 4.5e-16 59.2 0.0 7e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MccV PF17508.2 EDP43683.1 - 0.26 11.8 1.9 0.62 10.7 1.9 1.6 1 0 0 1 1 1 0 Microcin V bacteriocin Reticulon PF02453.17 EDP43684.1 - 0.005 16.8 1.9 0.47 10.4 0.1 2.2 2 0 0 2 2 2 2 Reticulon PRT_C PF08372.10 EDP43684.1 - 0.007 16.1 0.3 0.017 14.9 0.3 1.5 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal Med19 PF10278.9 EDP43684.1 - 0.039 13.9 12.9 0.1 12.5 12.9 1.6 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3292 PF11696.8 EDP43684.1 - 0.3 9.4 0.0 0.3 9.4 0.0 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3292) DUF639 PF04842.12 EDP43684.1 - 3.2 7.1 4.0 1.5 8.1 0.5 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) NAP PF00956.18 EDP43685.1 - 2.4e-20 72.9 15.2 7.4e-19 68.0 10.9 2.9 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) YL1 PF05764.13 EDP43685.1 - 0.063 13.4 16.7 0.095 12.8 16.7 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 EDP43685.1 - 1 8.6 15.3 1.3 8.3 15.3 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 EDP43685.1 - 1.6 6.9 9.5 1.9 6.7 9.5 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EDP43685.1 - 1.9 7.8 14.5 2.5 7.4 14.5 1.3 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 EDP43685.1 - 1.9 8.7 20.5 3.9 7.7 20.4 1.6 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 EDP43685.1 - 3.5 7.6 12.1 2.9 7.9 8.0 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4611 PF15387.6 EDP43685.1 - 3.6 7.9 16.9 0.62 10.3 10.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 EDP43685.1 - 4.1 5.5 15.1 5.3 5.1 15.1 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EDP43685.1 - 4.4 5.7 7.7 5.7 5.4 7.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 C2 PF00168.30 EDP43686.1 - 3.7e-47 158.9 0.0 2.1e-14 53.7 0.0 4.4 4 0 0 4 4 4 4 C2 domain Ank_4 PF13637.6 EDP43687.1 - 1e-13 51.5 2.1 1.1e-05 25.9 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDP43687.1 - 1.2e-12 48.2 0.2 5e-05 23.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP43687.1 - 1.2e-11 43.7 2.1 0.013 15.9 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EDP43687.1 - 1e-09 38.4 3.5 0.00045 20.6 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EDP43687.1 - 3.1e-08 33.7 0.6 0.0024 18.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) DUF572 PF04502.13 EDP43687.1 - 6.2 6.3 7.3 13 5.2 4.5 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF572) Arm PF00514.23 EDP43688.1 - 1.4e-95 310.7 13.3 2.4e-13 49.6 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EDP43688.1 - 2.3e-26 92.0 5.7 4.6e-26 91.1 5.7 1.5 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 EDP43688.1 - 9.3e-21 73.1 1.1 2.3e-20 71.9 1.1 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 EDP43688.1 - 2.8e-19 69.3 3.3 2.3e-05 24.7 0.0 6.0 1 1 6 7 7 7 7 HEAT repeats HEAT_EZ PF13513.6 EDP43688.1 - 1.3e-18 67.1 3.6 5.8e-06 26.7 0.0 6.9 2 1 6 8 8 8 5 HEAT-like repeat HEAT PF02985.22 EDP43688.1 - 6.6e-15 54.0 0.7 0.0026 17.9 0.0 6.9 6 0 0 6 6 6 2 HEAT repeat Arm_2 PF04826.13 EDP43688.1 - 3.4e-06 26.7 0.0 0.034 13.6 0.0 3.9 1 1 3 4 4 4 1 Armadillo-like RICTOR_V PF14668.6 EDP43688.1 - 6.6e-05 23.1 3.1 0.087 13.1 0.0 4.3 3 2 2 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 EDP43688.1 - 0.00046 18.9 0.0 0.022 13.3 0.0 2.4 1 1 1 3 3 3 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 EDP43688.1 - 0.00055 20.0 0.0 2.1 8.5 0.0 4.0 3 1 2 5 5 5 1 V-ATPase subunit H Atx10homo_assoc PF09759.9 EDP43688.1 - 0.0055 16.7 0.1 0.11 12.5 0.0 3.1 4 0 0 4 4 3 1 Spinocerebellar ataxia type 10 protein domain Mo25 PF08569.11 EDP43688.1 - 0.039 13.3 0.0 0.34 10.2 0.0 2.1 2 0 0 2 2 2 0 Mo25-like HEAT_PBS PF03130.16 EDP43688.1 - 0.064 14.0 4.3 1.2 10.0 0.0 4.4 6 0 0 6 6 3 0 PBS lyase HEAT-like repeat DUF4619 PF15398.6 EDP43688.1 - 0.083 12.4 3.2 0.13 11.7 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) PRP3 PF08572.10 EDP43689.1 - 2.4e-46 158.3 6.2 3.9e-46 157.6 6.2 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EDP43689.1 - 2.2e-44 151.1 0.0 4.7e-44 150.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) TRAUB PF08164.12 EDP43690.1 - 6.8e-24 84.2 2.3 1.8e-23 82.8 0.0 2.8 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EDP43690.1 - 2.1e-20 73.8 0.4 2.1e-20 73.8 0.4 3.2 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor Peptidase_S64 PF08192.11 EDP43690.1 - 2.6 6.4 7.9 0.82 8.1 5.1 1.6 2 0 0 2 2 2 0 Peptidase family S64 GTP_cyclohydro2 PF00925.20 EDP43691.1 - 6.6e-62 207.9 0.0 1.5e-61 206.8 0.0 1.6 1 1 0 1 1 1 1 GTP cyclohydrolase II LRR_6 PF13516.6 EDP43692.1 - 6.7e-05 22.6 4.4 2.3 8.5 0.2 5.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 EDP43692.1 - 0.0013 19.1 4.8 0.63 10.6 0.3 5.3 4 2 1 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EDP43692.1 - 0.0024 18.2 6.6 28 5.8 0.0 6.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 EDP43692.1 - 0.024 14.4 2.8 15 5.4 0.4 4.5 5 1 0 5 5 5 0 Leucine rich repeat Hydrolase_4 PF12146.8 EDP43693.1 - 4.7e-11 42.4 0.2 7.3e-09 35.2 0.2 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP43693.1 - 8.5e-10 38.7 0.1 1.7e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EDP43693.1 - 2.1e-08 34.3 0.0 3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP43693.1 - 4.4e-08 34.0 0.0 9.7e-08 32.9 0.0 1.6 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.14 EDP43693.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) tRNA-synt_2d PF01409.20 EDP43694.1 - 2.3e-46 158.3 0.0 4.3e-25 88.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EDP43694.1 - 1.9e-25 89.1 0.0 4.5e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF3305 PF11749.8 EDP43695.1 - 0.064 13.4 0.3 0.24 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3305) Inhibitor_I69 PF13734.6 EDP43695.1 - 0.31 11.5 2.9 3.2 8.2 0.2 2.8 2 0 0 2 2 2 0 Spi protease inhibitor DOT1 PF08123.13 EDP43696.1 - 6.5e-37 127.0 0.0 9.7e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 DUF3439 PF11921.8 EDP43696.1 - 0.3 11.1 1.5 0.59 10.1 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EDP43696.1 - 5.8 6.9 8.3 12 5.9 8.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Pkinase PF00069.25 EDP43697.1 - 4.4e-71 239.3 0.1 7e-71 238.7 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43697.1 - 2.5e-30 105.6 0.0 4.1e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43697.1 - 2e-07 30.6 0.0 3.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDP43697.1 - 0.00056 18.8 1.4 0.00058 18.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EDP43697.1 - 0.00057 19.3 1.2 0.00057 19.3 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EDP43697.1 - 0.041 13.4 0.3 0.078 12.5 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Vezatin PF12632.7 EDP43697.1 - 0.051 12.9 0.4 0.084 12.2 0.4 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes APH PF01636.23 EDP43697.1 - 0.056 13.3 2.4 0.095 12.6 0.2 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family PigN PF04987.14 EDP43698.1 - 2.6e-59 201.3 16.0 3.7e-59 200.8 16.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EDP43698.1 - 4.8e-10 39.6 1.4 7.7e-08 32.3 0.2 3.0 2 1 0 3 3 3 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EDP43698.1 - 0.0006 19.3 0.1 0.00095 18.6 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EDP43698.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Cation_ATPase_C PF00689.21 EDP43698.1 - 5.4 6.7 12.5 0.082 12.6 0.2 2.8 3 0 0 3 3 3 0 Cation transporting ATPase, C-terminus CNOT1_CAF1_bind PF16415.5 EDP43699.1 - 1.6e-87 292.6 1.2 3.3e-87 291.6 1.2 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EDP43699.1 - 6.5e-55 185.1 3.9 6.5e-55 185.1 1.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) Not1 PF04054.15 EDP43699.1 - 3.9e-54 184.0 0.2 9.8e-54 182.7 0.2 1.6 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_TTP_bind PF16417.5 EDP43699.1 - 1.3e-49 168.0 0.0 5e-49 166.1 0.0 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EDP43699.1 - 1.2e-34 119.6 0.1 3.5e-34 118.1 0.1 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat MMS19_C PF12460.8 EDP43699.1 - 7.8 5.5 11.5 1.9 7.5 0.3 3.7 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal ABC_membrane PF00664.23 EDP43700.1 - 2.3e-46 158.7 22.0 6.8e-28 98.1 9.2 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDP43700.1 - 2.3e-46 157.7 0.0 1.3e-27 97.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDP43700.1 - 3.8e-09 36.3 0.3 0.0033 16.9 0.2 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP43700.1 - 1.8e-05 24.4 0.2 0.13 12.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDP43700.1 - 2.1e-05 25.0 1.3 0.064 13.6 0.1 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDP43700.1 - 2.7e-05 24.5 0.6 0.68 10.2 0.0 3.7 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EDP43700.1 - 0.00038 20.4 4.8 1.2 8.8 0.1 3.6 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EDP43700.1 - 0.00098 19.2 0.2 0.57 10.3 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 EDP43700.1 - 0.011 15.8 1.9 0.21 11.7 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_23 PF13476.6 EDP43700.1 - 0.013 16.0 0.1 2 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDP43700.1 - 0.024 14.3 0.0 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDP43700.1 - 0.027 14.4 0.1 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase SbcCD_C PF13558.6 EDP43700.1 - 0.031 14.5 0.1 9.5 6.5 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 EDP43700.1 - 0.05 12.7 0.3 6.3 5.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.23 EDP43700.1 - 0.13 12.3 0.5 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AAA_30 PF13604.6 EDP43700.1 - 0.13 11.9 0.1 14 5.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EDP43700.1 - 0.14 11.7 0.0 10 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EDP43700.1 - 0.17 11.2 0.2 7.1 5.9 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family cobW PF02492.19 EDP43700.1 - 0.28 10.7 0.9 3.8 7.1 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EDP43700.1 - 0.29 11.0 1.5 39 4.1 0.0 3.8 4 0 0 4 4 3 0 NACHT domain AAA_33 PF13671.6 EDP43700.1 - 2 8.6 3.6 21 5.3 0.1 2.8 3 0 0 3 3 2 0 AAA domain PAC2 PF09754.9 EDP43701.1 - 4.9e-11 43.0 0.0 1.3e-10 41.6 0.0 1.7 1 1 0 1 1 1 1 PAC2 family MutS_V PF00488.21 EDP43702.1 - 2.9e-63 213.3 0.0 5.3e-63 212.5 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EDP43702.1 - 4.5e-36 124.9 5.9 8.3e-36 124.0 5.9 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EDP43702.1 - 3.2e-23 82.1 0.0 6.7e-23 81.1 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EDP43702.1 - 4.8e-08 33.4 0.0 1.4e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 EDP43702.1 - 0.00058 19.5 0.2 0.002 17.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDP43702.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EDP43703.1 - 4.6e-47 160.0 0.0 1.5e-27 96.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EDP43703.1 - 7.1e-44 150.5 36.8 8.3e-25 88.0 5.7 4.1 4 0 0 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.19 EDP43703.1 - 5.1e-10 39.2 3.6 0.0054 16.2 0.0 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP43703.1 - 1.1e-05 25.0 0.1 0.15 11.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDP43703.1 - 9.2e-05 22.4 2.1 1.2 8.8 0.0 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDP43703.1 - 9.6e-05 22.8 0.2 0.085 13.2 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDP43703.1 - 0.00031 21.0 0.4 1.4 9.1 0.1 3.7 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EDP43703.1 - 0.0014 18.7 0.2 0.66 10.1 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 EDP43703.1 - 0.01 16.1 0.1 2.9 8.2 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 EDP43703.1 - 0.025 13.7 0.2 6.9 5.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EDP43703.1 - 0.03 14.2 0.2 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EDP43703.1 - 0.037 13.8 0.1 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDP43703.1 - 0.038 13.6 0.0 6.2 6.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 EDP43703.1 - 0.051 13.3 0.1 7.3 6.2 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EDP43703.1 - 0.063 12.8 0.0 15 5.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_23 PF13476.6 EDP43703.1 - 0.064 13.7 5.4 2.2 8.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDP43703.1 - 0.13 11.5 0.2 15 4.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 EDP43703.1 - 0.14 11.9 0.2 14 5.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EDP43703.1 - 0.14 11.8 0.5 2.1 7.9 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EDP43703.1 - 0.16 12.0 1.5 0.24 11.5 0.1 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain Dynamin_N PF00350.23 EDP43703.1 - 0.64 10.1 4.9 0.81 9.7 0.0 3.0 3 0 0 3 3 3 0 Dynamin family DUF1279 PF06916.13 EDP43704.1 - 1.4e-17 64.0 0.1 3.1e-17 62.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) Ribosomal_S14 PF00253.21 EDP43705.1 - 2e-16 59.5 4.4 2.2e-16 59.3 4.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e COesterase PF00135.28 EDP43706.1 - 2e-06 27.0 0.5 2.9e-06 26.4 0.0 1.4 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 EDP43706.1 - 0.00058 19.4 0.0 0.0015 18.0 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EDP43706.1 - 0.024 14.5 0.1 0.061 13.2 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Aminotran_4 PF01063.19 EDP43707.1 - 8.5e-31 107.5 0.0 1.3e-30 107.0 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV WD40 PF00400.32 EDP43708.1 - 7.8e-06 26.5 15.9 0.63 11.0 3.0 6.1 5 2 0 5 5 5 3 WD domain, G-beta repeat PQQ_2 PF13360.6 EDP43708.1 - 0.0027 17.3 0.1 0.6 9.6 0.0 2.4 2 0 0 2 2 2 2 PQQ-like domain WD40_like PF17005.5 EDP43708.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.4 1 1 0 1 1 1 0 WD40-like domain DAGK_cat PF00781.24 EDP43708.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DEAD PF00270.29 EDP43709.1 - 3.7e-46 157.1 0.0 5.3e-45 153.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43709.1 - 1.6e-30 105.7 0.0 2.9e-29 101.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43709.1 - 0.00091 19.3 3.0 0.0066 16.5 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDP43709.1 - 0.056 12.8 0.0 0.056 12.8 0.0 3.1 2 2 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit FAM60A PF15396.6 EDP43709.1 - 1.2 9.1 13.3 2.4 8.1 13.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF5427 PF10310.9 EDP43709.1 - 3.5 6.5 16.6 5.1 5.9 15.8 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF2722 PF10846.8 EDP43709.1 - 5.5 5.8 17.4 8.7 5.2 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CH PF00307.31 EDP43710.1 - 4.2e-75 248.9 0.1 6.6e-20 71.3 0.0 4.4 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EDP43710.1 - 5e-09 35.9 0.0 0.025 14.4 0.0 4.5 4 0 0 4 4 4 3 CAMSAP CH domain EF-hand_7 PF13499.6 EDP43710.1 - 7.5e-07 29.5 2.1 1.7e-06 28.4 0.8 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EDP43710.1 - 0.0018 17.7 1.8 0.037 13.6 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 EDP43710.1 - 0.011 15.6 0.8 14 5.9 0.0 3.7 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 EDP43710.1 - 0.15 12.0 1.4 1.7 8.5 0.1 3.4 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.6 EDP43710.1 - 8 6.1 5.8 5 6.8 0.1 3.2 3 0 0 3 3 3 0 EF hand Na_sulph_symp PF00939.19 EDP43711.1 - 1.4e-32 113.4 36.3 1.8e-32 113.0 36.3 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EDP43711.1 - 5.6e-31 107.9 55.9 5.3e-27 94.8 29.8 1.6 1 1 1 2 2 2 2 Citrate transporter SPX PF03105.19 EDP43711.1 - 1.1e-16 61.7 6.0 2.6e-16 60.6 5.4 1.7 1 1 1 2 2 2 1 SPX domain TFIIA_gamma_N PF02268.16 EDP43711.1 - 0.15 12.1 0.0 0.44 10.6 0.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain Mito_carr PF00153.27 EDP43712.1 - 3.7e-53 177.4 0.9 1.9e-21 75.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PseudoU_synth_1 PF01416.20 EDP43713.1 - 3.7e-24 85.3 0.0 4.1e-20 72.2 0.0 3.3 3 0 0 3 3 3 2 tRNA pseudouridine synthase SET PF00856.28 EDP43714.1 - 6.3e-06 26.7 0.0 1.5e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 SET domain RRM_1 PF00076.22 EDP43715.1 - 1.6e-14 53.5 0.0 1.8e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP43715.1 - 0.0034 17.0 0.0 0.0042 16.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP43715.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif NUDIX PF00293.28 EDP43716.1 - 2.7e-24 85.7 0.0 4.1e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain CSN8_PSD8_EIF3K PF10075.9 EDP43717.1 - 1.1e-25 90.3 0.0 1.5e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PDT PF00800.18 EDP43718.1 - 5.1e-49 166.6 0.2 6.6e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Prephenate dehydratase Asp PF00026.23 EDP43719.1 - 3.5e-44 151.5 1.4 2.2e-43 148.9 1.4 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EDP43719.1 - 6.2e-10 39.6 0.3 0.00017 22.2 0.1 2.4 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP43719.1 - 1.3e-06 28.9 0.1 0.015 15.8 0.0 2.7 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EDP43719.1 - 0.00026 20.8 0.1 0.00058 19.7 0.1 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EDP43719.1 - 0.003 17.8 0.2 0.041 14.1 0.1 2.6 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal Bap31_Bap29_C PF18035.1 EDP43719.1 - 0.0067 16.4 0.1 0.011 15.7 0.1 1.3 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DAHP_synth_2 PF01474.16 EDP43720.1 - 4.1e-191 635.2 0.0 4.6e-191 635.1 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Sec34 PF04136.15 EDP43721.1 - 4.3e-25 88.3 2.6 4.3e-25 88.3 2.6 2.1 2 1 0 2 2 2 1 Sec34-like family EMP24_GP25L PF01105.24 EDP43721.1 - 0.93 9.4 4.1 0.58 10.1 0.5 2.4 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Phage_GPO PF05929.11 EDP43721.1 - 2.8 7.5 7.4 4.4 6.9 0.9 2.3 1 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase CTD_bind PF04818.13 EDP43723.1 - 0.00014 22.6 0.0 0.00029 21.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Ribosomal_L6 PF00347.23 EDP43724.1 - 1.6e-23 83.2 2.1 1e-12 48.5 0.2 2.4 2 1 0 2 2 2 2 Ribosomal protein L6 Ribosomal_L37e PF01907.19 EDP43725.1 - 4.1e-27 94.1 13.9 7.2e-27 93.3 13.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.18 EDP43725.1 - 0.0075 16.3 0.2 0.0085 16.2 0.2 1.1 1 0 0 1 1 1 1 SelR domain DZR PF12773.7 EDP43725.1 - 0.03 14.4 2.4 0.046 13.8 2.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon DUF1462 PF07315.11 EDP43725.1 - 0.11 12.8 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) Ribosomal_L7Ae PF01248.26 EDP43726.1 - 2.9e-20 71.8 0.0 3.2e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FKBP_C PF00254.28 EDP43726.1 - 0.028 14.7 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase Cyclin_N PF00134.23 EDP43727.1 - 1.2e-37 128.5 0.6 2.9e-37 127.2 0.6 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EDP43727.1 - 1.1e-09 38.4 0.2 2.8e-09 37.1 0.2 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain zf-LYAR PF08790.11 EDP43728.1 - 2.6e-10 40.0 1.8 6.8e-10 38.7 1.8 1.8 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EDP43728.1 - 0.021 14.4 0.3 0.62 9.7 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger MBF1 PF08523.10 EDP43729.1 - 5.2e-19 68.5 0.2 1.1e-18 67.5 0.2 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EDP43729.1 - 2.5e-11 43.4 0.2 4.2e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EDP43729.1 - 1.7e-05 25.1 0.0 3.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 EDP43729.1 - 0.01 15.9 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Joubert PF15392.6 EDP43729.1 - 0.015 15.0 0.1 0.017 14.9 0.1 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated Pkinase PF00069.25 EDP43730.1 - 1.7e-55 188.3 0.0 7.5e-55 186.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43730.1 - 6.3e-32 110.9 0.0 5.8e-30 104.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43730.1 - 1.3e-07 31.3 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EDP43730.1 - 1.5e-05 24.0 0.0 2.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EDP43730.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDP43730.1 - 0.14 12.1 0.2 1.2 9.0 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family I-set PF07679.16 EDP43731.1 - 0.024 14.7 0.0 0.066 13.3 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin I-set domain JAB PF01398.21 EDP43732.1 - 2.8e-20 72.5 0.0 4.5e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDP43732.1 - 1.4e-16 60.9 0.2 3.7e-16 59.5 0.0 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Methyltransf_4 PF02390.17 EDP43733.1 - 3.3e-53 179.7 0.0 1.2e-39 135.5 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_25 PF13649.6 EDP43733.1 - 0.00048 20.8 0.0 0.022 15.5 0.0 2.5 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43733.1 - 0.0012 19.6 0.1 0.0035 18.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDP43733.1 - 0.0018 17.9 0.0 0.08 12.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EDP43733.1 - 0.0018 18.3 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF913 PF06025.12 EDP43733.1 - 0.0036 16.4 0.0 0.0049 15.9 0.0 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Methyltransf_11 PF08241.12 EDP43733.1 - 0.042 14.5 0.0 4.1 8.1 0.0 2.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EDP43733.1 - 0.1 12.4 0.0 0.33 10.7 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain Prefoldin_2 PF01920.20 EDP43734.1 - 3e-17 62.5 3.2 3.2e-17 62.4 3.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF4924 PF16271.5 EDP43734.1 - 0.046 13.7 0.1 0.055 13.5 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4924) DUF641 PF04859.12 EDP43734.1 - 0.21 11.9 5.2 0.53 10.6 0.5 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EDP43734.1 - 0.52 11.0 3.9 2.6 8.7 0.4 2.3 2 1 0 2 2 2 0 SlyX ANAPC3 PF12895.7 EDP43735.1 - 0.0017 18.5 1.3 0.7 10.2 0.2 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF445 PF04286.12 EDP43735.1 - 0.011 15.6 0.5 0.027 14.3 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF445) PC_rep PF01851.22 EDP43735.1 - 0.016 15.6 0.1 0.11 12.9 0.0 2.5 3 0 0 3 3 3 0 Proteasome/cyclosome repeat MetRS-N PF09635.10 EDP43735.1 - 0.053 14.1 0.9 0.99 10.0 0.0 3.0 2 1 1 3 3 3 0 MetRS-N binding domain CENP-T_C PF15511.6 EDP43735.1 - 0.18 11.9 0.7 15 5.7 0.0 3.2 3 0 0 3 3 3 0 Centromere kinetochore component CENP-T histone fold RPN2_C PF18004.1 EDP43736.1 - 6.7e-37 126.9 0.7 6.7e-37 126.9 0.7 3.3 2 1 1 3 3 3 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EDP43736.1 - 4.2e-24 83.7 19.0 6.4e-09 35.8 0.2 6.5 6 0 0 6 6 6 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EDP43736.1 - 1.4e-16 60.6 2.5 3.4e-15 56.2 0.1 3.4 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EDP43736.1 - 2.6e-05 24.1 1.1 0.56 10.6 0.2 3.7 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 EDP43736.1 - 6.9e-05 23.3 2.7 0.13 12.8 0.8 3.9 2 1 2 4 4 4 4 HEAT-like repeat Vfa1 PF08432.10 EDP43736.1 - 0.61 10.4 13.2 0.11 12.8 1.0 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Beta_elim_lyase PF01212.21 EDP43737.1 - 1.1e-31 110.2 0.4 1.4e-31 109.9 0.4 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EDP43737.1 - 0.011 15.0 0.1 0.018 14.4 0.1 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EDP43737.1 - 0.12 10.9 0.1 0.15 10.6 0.1 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme NAD_binding_4 PF07993.12 EDP43738.1 - 0.058 12.6 0.0 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein Syja_N PF02383.18 EDP43739.1 - 7.6e-86 288.3 0.0 9.9e-86 287.9 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Prp19 PF08606.11 EDP43740.1 - 6.2e-28 96.6 3.1 6.6e-28 96.5 1.5 1.9 2 0 0 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 EDP43740.1 - 4.1e-23 81.2 11.2 3.9e-05 24.3 0.0 7.5 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43740.1 - 1.1e-12 48.1 0.1 0.0013 19.0 0.0 5.3 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDP43740.1 - 0.038 13.3 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain DUF5046 PF16465.5 EDP43740.1 - 0.044 13.2 2.3 4.4 6.7 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 EDP43740.1 - 0.045 12.3 0.1 0.096 11.2 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EDP43740.1 - 0.054 12.5 0.5 1.1 8.2 0.0 2.8 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IGPS PF00218.21 EDP43741.1 - 1.7e-88 296.1 0.4 1.3e-86 289.9 0.1 2.7 3 0 0 3 3 3 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EDP43741.1 - 5e-44 150.4 0.0 6.7e-38 130.4 0.0 2.5 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EDP43741.1 - 3.9e-41 140.9 0.1 2.3e-40 138.4 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDP43741.1 - 1.9e-06 27.8 5.6 2.1e-06 27.7 2.1 2.7 2 1 0 2 2 2 1 Peptidase C26 QRPTase_C PF01729.19 EDP43741.1 - 0.0075 16.1 0.1 0.045 13.5 0.1 2.3 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain ThiG PF05690.14 EDP43741.1 - 0.0091 15.3 4.2 0.023 14.0 0.0 2.8 2 1 0 3 3 3 1 Thiazole biosynthesis protein ThiG Actin PF00022.19 EDP43742.1 - 2.3e-06 26.5 0.0 3e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Actin PGM_PMM_I PF02878.16 EDP43743.1 - 7.4e-20 71.1 0.0 3.7e-09 36.4 0.0 3.1 3 1 0 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EDP43743.1 - 1.9e-10 40.8 0.1 3.9e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EDP43743.1 - 8.4e-06 26.4 0.5 9.9e-05 22.9 0.2 2.8 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EDP43743.1 - 0.001 19.3 0.2 0.004 17.4 0.2 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Amidohydro_1 PF01979.20 EDP43743.1 - 0.043 13.1 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase family PQ-loop PF04193.14 EDP43744.1 - 4.4e-11 42.4 0.8 6.7e-11 41.8 0.0 1.8 2 0 0 2 2 2 1 PQ loop repeat MFS_1 PF07690.16 EDP43745.1 - 5.3e-19 68.3 18.5 9.8e-19 67.5 18.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP43745.1 - 8.8e-16 57.8 1.8 8.8e-16 57.8 1.8 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter JAB PF01398.21 EDP43746.1 - 2.3e-08 34.0 0.0 7.7e-08 32.3 0.0 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HCV_NS2 PF01538.18 EDP43746.1 - 0.049 13.3 0.1 0.12 12.0 0.1 1.6 1 1 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 bVLRF1 PF18826.1 EDP43747.1 - 7.4e-51 171.9 0.2 1.6e-50 170.8 0.2 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor YlbD_coat PF14071.6 EDP43747.1 - 0.82 9.9 3.7 11 6.4 0.1 3.1 3 0 0 3 3 3 0 Putative coat protein Ssu72 PF04722.13 EDP43748.1 - 8.9e-75 250.5 0.0 9.9e-75 250.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein DUF507 PF04368.13 EDP43748.1 - 0.039 13.9 0.9 0.066 13.2 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) LAG1-DNAbind PF09271.11 EDP43749.1 - 9e-24 84.8 0.0 7.2e-22 78.6 0.0 2.4 1 1 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 EDP43749.1 - 1.8e-16 60.7 0.0 3.6e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain DUF501 PF04417.12 EDP43749.1 - 0.004 17.0 0.8 0.0097 15.7 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF501) Las1 PF04031.13 EDP43750.1 - 2e-42 144.9 0.3 4.4e-42 143.8 0.3 1.6 1 0 0 1 1 1 1 Las1-like Thioredoxin_4 PF13462.6 EDP43751.1 - 7.3e-07 29.5 0.0 5.5e-06 26.6 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin ADP_ribosyl_GH PF03747.14 EDP43751.1 - 0.026 14.3 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase SAICAR_synt PF01259.18 EDP43752.1 - 5.9e-95 317.6 0.0 7.5e-95 317.3 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase Kinesin PF00225.23 EDP43753.1 - 7.8e-105 350.5 1.2 2.6e-104 348.8 0.1 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EDP43753.1 - 1.5e-25 89.9 0.0 3.6e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 EDP43753.1 - 0.037 13.9 2.8 0.94 9.3 0.0 3.2 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_7 PF12775.7 EDP43753.1 - 0.15 11.6 0.2 0.57 9.7 0.1 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region HsbA PF12296.8 EDP43753.1 - 0.24 11.8 16.2 0.071 13.5 1.0 4.1 3 1 0 3 3 3 0 Hydrophobic surface binding protein A AAA_22 PF13401.6 EDP43753.1 - 0.49 10.7 3.1 15 5.8 0.0 3.9 3 1 1 4 4 4 0 AAA domain PIN_8 PF18476.1 EDP43753.1 - 4.1 7.2 20.9 4.7 7.0 0.2 3.6 2 2 2 4 4 4 0 PIN like domain Baculo_PEP_C PF04513.12 EDP43753.1 - 7.1 6.7 20.8 0.16 12.0 5.7 4.4 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus WD40 PF00400.32 EDP43754.1 - 1.6e-49 164.8 15.7 2.1e-09 37.9 0.9 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43754.1 - 1.1e-20 73.7 2.7 0.0023 18.2 0.0 5.9 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP43754.1 - 1.9e-08 33.6 0.8 0.0059 15.6 0.1 3.5 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDP43754.1 - 1e-06 27.7 7.2 0.053 12.2 0.1 4.1 1 1 4 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EDP43754.1 - 0.0014 18.0 0.0 1.2 8.4 0.0 2.9 3 0 0 3 3 3 2 WD40-like domain PALB2_WD40 PF16756.5 EDP43754.1 - 2.4 7.0 6.9 14 4.5 0.1 3.7 2 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain RNA_pol_Rpb4 PF03874.16 EDP43755.1 - 9e-14 51.9 0.1 1.1e-13 51.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Rhomboid PF01694.22 EDP43756.1 - 1e-10 41.8 1.8 1.1e-10 41.6 0.4 1.8 2 0 0 2 2 2 1 Rhomboid family Aminotran_1_2 PF00155.21 EDP43757.1 - 3.4e-49 167.9 0.0 1e-48 166.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDP43757.1 - 0.00025 19.7 0.0 0.04 12.4 0.0 2.1 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EDP43757.1 - 0.012 14.5 0.0 2.1 7.2 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDP43757.1 - 0.025 13.8 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_3 PF00202.21 EDP43757.1 - 0.072 11.7 0.2 0.12 10.9 0.2 1.3 1 0 0 1 1 1 0 Aminotransferase class-III PXB PF12828.7 EDP43758.1 - 5.7e-24 84.6 0.7 2.5e-23 82.5 0.0 2.5 3 0 0 3 3 3 1 PX-associated DUF3818 PF12825.7 EDP43758.1 - 4.9e-23 81.7 0.0 4.9e-23 81.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) Pex24p PF06398.11 EDP43758.1 - 0.97 8.3 3.4 0.98 8.3 0.0 2.1 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Asp-B-Hydro_N PF05279.11 EDP43758.1 - 3.7 7.5 15.7 8.6 6.4 15.7 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 EDP43758.1 - 5.6 5.6 11.8 8.5 5.0 11.8 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EDP43758.1 - 5.9 6.6 15.9 11 5.8 15.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2433 PF10360.9 EDP43759.1 - 6.9e-42 142.5 0.0 1.2e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 EDP43759.1 - 0.016 15.0 0.1 0.059 13.2 0.1 2.0 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos_2 PF12850.7 EDP43759.1 - 0.042 14.0 0.0 0.13 12.4 0.0 1.9 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Nup35_RRM PF05172.13 EDP43759.1 - 0.2 11.6 0.0 0.43 10.6 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif FXMRP1_C_core PF12235.8 EDP43759.1 - 3.8 8.1 8.3 0.28 11.8 2.8 1.9 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal GTP_EFTU PF00009.27 EDP43760.1 - 1.3e-33 116.2 0.3 5.9e-33 114.1 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDP43760.1 - 1.2e-17 64.0 0.0 2.9e-17 62.7 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EDP43760.1 - 2.3e-13 50.3 5.7 1.1e-10 41.7 0.2 3.5 4 0 0 4 4 4 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP43760.1 - 1.5e-05 25.1 0.0 5.9e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EDP43760.1 - 0.0021 18.3 0.0 0.0051 17.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EDP43760.1 - 0.0023 17.8 0.0 0.0054 16.5 0.0 1.7 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU_D4 PF14578.6 EDP43760.1 - 0.06 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 Ras PF00071.22 EDP43760.1 - 0.093 12.3 0.0 0.33 10.5 0.0 1.9 1 1 0 1 1 1 0 Ras family AAA_22 PF13401.6 EDP43760.1 - 0.21 11.9 1.2 1.5 9.1 0.3 2.7 2 1 0 2 2 2 0 AAA domain US6 PF17616.2 EDP43760.1 - 3.4 7.6 7.4 0.97 9.4 0.2 3.2 3 0 0 3 3 3 0 Viral unique short region 6 CPSase_L_D2 PF02786.17 EDP43761.1 - 2.8e-104 347.2 0.0 1.3e-81 273.2 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EDP43761.1 - 2.1e-39 134.6 0.1 6.4e-39 133.1 0.1 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EDP43761.1 - 3.4e-18 65.8 0.0 1.1e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EDP43761.1 - 3.3e-13 49.5 0.0 1.5e-05 24.7 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 EDP43761.1 - 4.7e-13 49.1 0.0 6e-06 25.9 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.6 EDP43761.1 - 1.9e-06 27.5 0.5 0.0082 15.6 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.14 EDP43761.1 - 1.3e-05 25.3 0.0 0.0021 18.1 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 EDP43761.1 - 0.0025 17.4 0.0 2.3 7.8 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 EDP43761.1 - 0.0034 17.2 0.0 2.4 7.9 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Peptidase_M17_N PF02789.17 EDP43761.1 - 0.029 14.2 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain DUF4743 PF15916.5 EDP43761.1 - 0.058 13.4 0.0 8.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) MGS PF02142.22 EDP43761.1 - 0.078 13.2 0.0 0.36 11.1 0.0 2.2 2 0 0 2 2 2 0 MGS-like domain Epimerase PF01370.21 EDP43761.1 - 0.078 12.4 0.0 1.5 8.2 0.0 2.9 4 0 0 4 4 4 0 NAD dependent epimerase/dehydratase family Abhydrolase_1 PF00561.20 EDP43762.1 - 6.3e-14 52.2 0.8 2e-11 44.0 0.2 2.7 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EDP43762.1 - 2.2e-12 46.3 0.0 4e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EDP43762.1 - 1.3e-09 37.7 0.0 2.8e-09 36.6 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 MAM33 PF02330.16 EDP43764.1 - 6.7e-70 235.3 0.0 7.7e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein Big_7 PF17957.1 EDP43764.1 - 0.19 12.5 0.0 0.35 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig domain Thioredoxin PF00085.20 EDP43765.1 - 2.8e-34 117.2 0.0 3.5e-18 65.5 0.0 3.0 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EDP43765.1 - 2.5e-09 37.3 0.0 1.6e-07 31.5 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 EDP43765.1 - 4.7e-05 23.6 0.2 0.41 10.8 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 EDP43765.1 - 8.4e-05 22.1 0.0 0.2 11.0 0.0 2.8 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDP43765.1 - 0.00023 21.4 0.1 0.096 13.0 0.0 3.3 3 1 0 3 3 3 1 Thioredoxin-like Thioredoxin_3 PF13192.6 EDP43765.1 - 0.003 17.6 0.4 0.079 13.0 0.1 2.8 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_7 PF13899.6 EDP43765.1 - 0.099 12.8 0.7 12 6.1 0.0 3.1 3 0 0 3 3 3 0 Thioredoxin-like Thioredoxin_2 PF13098.6 EDP43765.1 - 0.14 12.6 1.4 22 5.6 0.2 3.0 3 1 0 3 3 3 0 Thioredoxin-like domain ERp29_N PF07912.13 EDP43765.1 - 0.18 11.9 0.1 0.58 10.3 0.0 1.8 2 0 0 2 2 2 0 ERp29, N-terminal domain HscB_4_cys PF18256.1 EDP43765.1 - 5.3 6.9 9.9 15 5.5 1.3 2.4 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif RICTOR_N PF14664.6 EDP43766.1 - 1.1e-51 176.0 8.6 6.7e-51 173.4 1.3 2.8 2 1 1 3 3 3 2 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 EDP43766.1 - 2.1e-21 75.6 0.1 3.2e-20 71.8 0.0 3.2 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EDP43766.1 - 6.6e-21 74.3 0.1 3.4e-20 72.1 0.0 2.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 EDP43766.1 - 3.2e-12 46.8 0.0 1.8e-11 44.4 0.0 2.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HR1 PF02185.16 EDP43766.1 - 5e-07 29.7 1.5 1.9e-06 27.9 1.5 2.0 1 0 0 1 1 1 1 Hr1 repeat HEAT PF02985.22 EDP43766.1 - 0.041 14.1 0.3 3.3 8.2 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat Uds1 PF15456.6 EDP43766.1 - 0.042 14.0 0.7 0.13 12.4 0.7 1.8 1 0 0 1 1 1 0 Up-regulated During Septation DUF4140 PF13600.6 EDP43766.1 - 0.13 12.7 1.5 0.34 11.4 1.5 1.6 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HEAT_EZ PF13513.6 EDP43766.1 - 8.4 7.0 14.4 0.19 12.3 0.2 5.0 4 1 1 5 5 5 0 HEAT-like repeat Coa1 PF08695.10 EDP43767.1 - 7.7e-35 119.2 0.0 9.8e-35 118.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Macoilin PF09726.9 EDP43768.1 - 5.9 5.3 9.8 8.1 4.9 9.8 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_S16 PF00886.19 EDP43769.1 - 6.7e-27 93.3 0.3 1.2e-26 92.5 0.3 1.5 1 1 0 1 1 1 1 Ribosomal protein S16 Med26 PF08711.11 EDP43770.1 - 0.00068 19.6 0.4 0.0015 18.5 0.4 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Methyltransf_28 PF02636.17 EDP43771.1 - 4.8e-36 124.7 0.0 7.8e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 EDP43771.1 - 0.0023 18.7 0.0 0.019 15.7 0.0 2.6 4 0 0 4 4 4 1 Methyltransferase domain DUF5063 PF16702.5 EDP43771.1 - 0.079 13.3 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) MMgT PF10270.9 EDP43772.1 - 8.5e-15 54.9 0.0 1.1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter Actin PF00022.19 EDP43773.1 - 1.9e-149 497.7 0.0 9e-149 495.5 0.0 1.8 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 EDP43773.1 - 0.0049 15.5 0.0 0.007 15.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Nop PF01798.18 EDP43774.1 - 1e-84 283.6 0.0 1e-84 283.6 0.0 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDP43774.1 - 2.2e-18 66.4 0.1 2.2e-18 66.4 0.1 2.6 2 0 0 2 2 2 1 NOP5NT (NUC127) domain SDA1 PF05285.12 EDP43774.1 - 0.02 14.3 30.3 0.028 13.9 30.3 1.2 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 EDP43774.1 - 0.71 10.0 35.4 1 9.4 35.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Proteasome PF00227.26 EDP43775.1 - 3.3e-50 170.2 0.5 2.8e-48 164.0 0.5 2.2 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDP43775.1 - 3.4e-15 55.4 0.1 6.3e-15 54.5 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TPR_2 PF07719.17 EDP43776.1 - 2.8e-08 33.3 42.0 0.023 14.8 0.0 11.3 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43776.1 - 0.0015 19.2 2.7 0.0015 19.2 2.7 14.7 14 2 2 16 16 16 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDP43776.1 - 0.003 17.3 23.7 3.6 7.5 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43776.1 - 0.0031 18.0 39.9 6 7.5 3.0 11.1 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDP43776.1 - 0.0056 17.2 0.7 0.0056 17.2 0.7 9.0 11 1 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43776.1 - 0.0059 17.2 5.1 0.0059 17.2 5.1 12.1 13 1 0 13 13 13 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDP43776.1 - 0.036 13.8 0.0 0.036 13.8 0.0 5.1 6 0 0 6 6 6 0 TPR repeat TPR_17 PF13431.6 EDP43776.1 - 0.066 13.6 21.6 17 6.1 0.1 8.0 9 1 0 9 9 9 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43776.1 - 0.075 13.3 10.7 1.6 9.2 0.4 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF2852 PF11014.8 EDP43776.1 - 0.33 11.1 3.0 0.95 9.6 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) SNO PF01174.19 EDP43777.1 - 7.4e-49 166.2 0.0 1.2e-38 132.9 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EDP43777.1 - 6.6e-09 35.6 0.0 9.1e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 EDP43777.1 - 0.00041 20.1 0.0 0.00061 19.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 EDP43777.1 - 0.00045 20.1 0.1 0.00066 19.5 0.1 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family BPL_N PF09825.9 EDP43777.1 - 0.022 13.9 0.0 0.15 11.1 0.0 1.9 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal Peptidase_C26 PF07722.13 EDP43777.1 - 0.074 12.8 0.2 0.2 11.4 0.2 1.8 1 1 0 1 1 1 0 Peptidase C26 MT-A70 PF05063.14 EDP43778.1 - 4.5e-16 59.3 0.0 6.5e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Cpn60_TCP1 PF00118.24 EDP43779.1 - 1.6e-145 485.5 11.5 1.8e-145 485.4 11.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 EDP43779.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat COX4 PF02936.14 EDP43780.1 - 1.4e-33 115.8 0.0 2.1e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV ASXH PF13919.6 EDP43780.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Asx homology domain Cys_Met_Meta_PP PF01053.20 EDP43781.1 - 1.2e-150 501.4 0.0 1.3e-150 501.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDP43781.1 - 2.3e-12 46.8 0.0 3.5e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EDP43781.1 - 5.9e-09 35.7 0.0 1.4e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EDP43781.1 - 4.8e-08 32.4 0.1 8.3e-08 31.6 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDP43781.1 - 0.00035 19.9 0.0 0.00081 18.8 0.0 1.7 2 1 0 2 2 2 1 Beta-eliminating lyase AP_endonuc_2 PF01261.24 EDP43781.1 - 0.0028 17.1 0.1 0.091 12.2 0.0 2.5 1 1 0 2 2 2 1 Xylose isomerase-like TIM barrel Met_gamma_lyase PF06838.11 EDP43781.1 - 0.093 11.2 0.1 0.21 10.1 0.1 1.6 1 1 0 1 1 1 0 Methionine gamma-lyase Asparaginase_C PF17763.1 EDP43781.1 - 0.13 12.5 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain Radical_SAM PF04055.21 EDP43781.1 - 0.18 12.2 0.0 2.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Radical SAM superfamily Cys_Met_Meta_PP PF01053.20 EDP43782.1 - 2.6e-117 391.6 0.0 3.9e-117 391.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GHMP_kinases_N PF00288.26 EDP43782.1 - 3e-15 56.2 0.1 3.2e-14 52.9 0.0 2.7 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDP43782.1 - 7e-05 23.1 0.1 0.00017 21.9 0.1 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EDP43782.1 - 0.026 14.1 0.1 0.052 13.1 0.1 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature RTC PF01137.21 EDP43783.1 - 3.6e-53 180.0 0.0 4.2e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EDP43783.1 - 9.5e-34 116.0 0.0 2.1e-33 114.9 0.0 1.6 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF2347 PF09804.9 EDP43784.1 - 9.9e-35 120.5 0.0 2.5e-19 70.0 0.0 2.2 1 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 EDP43784.1 - 0.0029 16.4 0.0 1.9 7.1 0.0 2.4 2 0 0 2 2 2 2 Transport protein Avl9 MFAP1 PF06991.11 EDP43785.1 - 3.2e-59 200.4 14.8 5.9e-59 199.5 14.8 1.4 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing Arf PF00025.21 EDP43786.1 - 1.7e-52 177.4 0.0 6.1e-51 172.3 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EDP43786.1 - 4.3e-09 36.0 0.0 5.2e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 EDP43786.1 - 1.1e-07 32.0 0.0 1.5e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDP43786.1 - 1e-06 28.3 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDP43786.1 - 4.1e-06 26.5 0.0 4.9e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDP43786.1 - 3e-05 23.5 0.0 3.6e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDP43786.1 - 0.0034 16.9 0.0 0.0046 16.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EDP43786.1 - 0.0057 16.7 0.0 0.0087 16.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SNF2_N PF00176.23 EDP43787.1 - 2.6e-60 204.0 0.0 4.7e-60 203.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP43787.1 - 6e-19 68.4 0.0 2.4e-18 66.5 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EDP43787.1 - 6.4e-11 42.4 5.2 6.4e-11 42.4 5.2 2.7 3 0 0 3 3 3 1 HSA ResIII PF04851.15 EDP43787.1 - 1.7e-09 37.9 0.0 6e-09 36.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDP43787.1 - 0.0002 21.2 0.1 0.00073 19.4 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase ATP-synt_Eps PF04627.13 EDP43788.1 - 4.1e-19 68.3 5.0 4.8e-19 68.1 5.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain PRRSV_Env PF02340.15 EDP43788.1 - 0.056 12.8 0.1 0.063 12.7 0.1 1.0 1 0 0 1 1 1 0 PRRSV putative envelope protein DUF423 PF04241.15 EDP43789.1 - 1.2e-05 25.5 4.0 0.0012 19.0 0.3 2.5 2 1 1 3 3 3 2 Protein of unknown function (DUF423) Nucleoporin_FG PF13634.6 EDP43790.1 - 2.1e-06 28.5 192.1 0.078 13.8 15.4 11.1 3 1 8 11 11 11 8 Nucleoporin FG repeat region RabGAP-TBC PF00566.18 EDP43791.1 - 3.9e-23 82.2 0.2 2.8e-21 76.2 0.2 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain XPA_C PF05181.12 EDP43791.1 - 0.063 13.2 0.0 1.8 8.6 0.0 2.6 2 0 0 2 2 2 0 XPA protein C-terminus PHtD_u1 PF16645.5 EDP43791.1 - 0.082 13.4 2.6 0.17 12.3 0.3 2.7 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein CDC50 PF03381.15 EDP43792.1 - 7.9e-85 284.8 0.0 1e-84 284.4 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family GTP_EFTU PF00009.27 EDP43793.1 - 1.6e-23 83.2 0.0 5.5e-22 78.3 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EDP43793.1 - 6.7e-08 32.8 0.2 2.5e-07 31.0 0.2 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP43793.1 - 0.0024 18.0 0.0 0.0081 16.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDP43793.1 - 0.0051 16.7 0.3 3.4 7.5 0.0 3.1 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU_D3 PF03143.17 EDP43793.1 - 0.008 16.5 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MR_MLE_N PF02746.16 EDP43793.1 - 0.016 15.4 0.6 0.043 14.0 0.1 2.0 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Arf PF00025.21 EDP43793.1 - 0.067 12.6 0.8 14 5.1 0.0 2.8 3 0 0 3 3 3 0 ADP-ribosylation factor family PduV-EutP PF10662.9 EDP43793.1 - 0.14 11.9 0.2 32 4.2 0.0 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EDP43793.1 - 0.15 11.6 0.2 5.5 6.5 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B GTP_EFTU_D4 PF14578.6 EDP43793.1 - 0.17 11.8 2.6 2.1 8.3 0.1 3.2 4 1 0 4 4 4 0 Elongation factor Tu domain 4 Y_phosphatase2 PF03162.13 EDP43794.1 - 4e-16 59.0 0.1 6e-16 58.5 0.1 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Oxysterol_BP PF01237.18 EDP43795.1 - 1.5e-74 251.1 0.0 1.9e-74 250.8 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein TPR_1 PF00515.28 EDP43796.1 - 1.3e-46 154.5 16.9 0.00016 21.3 0.2 10.7 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EDP43796.1 - 1.3e-40 134.3 14.9 0.00041 20.2 0.1 10.5 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 EDP43796.1 - 1.8e-30 102.6 11.9 0.00015 21.7 0.0 10.0 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 EDP43796.1 - 6.6e-29 98.1 4.7 0.0097 16.7 0.0 10.0 4 3 6 10 10 10 7 Tetratricopeptide repeat TPR_19 PF14559.6 EDP43796.1 - 2.5e-22 79.2 3.8 0.00032 21.2 0.0 7.6 4 2 3 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 EDP43796.1 - 1.6e-20 71.6 13.1 0.033 14.2 0.0 9.2 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 EDP43796.1 - 1.9e-19 69.6 1.7 0.0021 18.2 0.0 6.5 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_6 PF13174.6 EDP43796.1 - 6.1e-19 67.3 5.2 0.4 11.4 0.4 9.5 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EDP43796.1 - 3.8e-18 65.8 0.6 0.022 15.4 0.0 7.6 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP43796.1 - 3.7e-17 62.4 18.1 0.00098 19.4 0.2 7.7 4 4 2 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EDP43796.1 - 1.1e-14 53.8 20.8 0.0021 17.7 0.4 8.8 5 2 4 9 9 9 6 TPR repeat TPR_17 PF13431.6 EDP43796.1 - 1.8e-14 53.0 9.1 0.078 13.4 0.0 9.3 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_15 PF13429.6 EDP43796.1 - 2.5e-09 36.7 6.1 0.097 11.9 0.0 5.4 1 1 4 6 6 6 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP43796.1 - 1.1e-08 35.2 3.4 0.00045 20.4 0.1 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EDP43796.1 - 2e-05 24.4 1.1 0.097 12.4 0.0 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 EDP43796.1 - 0.065 13.6 0.1 4.5 7.7 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 EDP43796.1 - 0.1 11.6 0.2 1.5 7.8 0.0 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 EDP43796.1 - 2.7 8.0 15.7 12 5.9 0.0 6.0 7 0 0 7 7 5 0 Tetratricopeptide repeat PE PF00934.20 EDP43796.1 - 3.2 8.1 7.7 0.13 12.6 1.2 2.0 2 0 0 2 2 1 0 PE family SOR_SNZ PF01680.17 EDP43797.1 - 2.9e-113 376.7 4.9 4.8e-113 376.0 4.9 1.4 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EDP43797.1 - 1.9e-06 27.4 7.9 3.6e-05 23.2 0.6 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 EDP43797.1 - 0.0088 15.2 0.2 3.7 6.6 0.0 2.5 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 EDP43797.1 - 0.026 13.9 5.5 0.2 11.0 0.2 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase NanE PF04131.14 EDP43797.1 - 0.029 13.5 0.4 0.15 11.2 0.0 2.2 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 EDP43797.1 - 0.081 12.1 0.7 1.1 8.4 0.0 2.5 3 0 0 3 3 3 0 Indole-3-glycerol phosphate synthase Rieske PF00355.26 EDP43798.1 - 5e-11 42.4 0.0 9e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EDP43798.1 - 1.1e-09 38.7 0.4 3.5e-09 37.0 0.4 1.9 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region SPT16 PF08644.11 EDP43799.1 - 2.7e-54 183.4 2.5 9.2e-54 181.7 0.2 2.4 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Rtt106 PF08512.12 EDP43799.1 - 4.3e-15 55.9 1.0 1.8e-14 53.9 0.0 2.6 4 0 0 4 4 4 1 Histone chaperone Rttp106-like Atg8 PF02991.16 EDP43800.1 - 2.9e-48 162.4 0.1 3.4e-48 162.1 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EDP43800.1 - 4.9e-07 30.1 0.0 6.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 HEAT PF02985.22 EDP43801.1 - 1.2e-09 37.6 13.5 0.0096 16.1 0.1 8.2 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 EDP43801.1 - 1.2e-05 25.7 0.5 0.36 11.3 0.0 5.2 4 1 1 5 5 5 1 HEAT repeats SDA1 PF05285.12 EDP43801.1 - 1.8 7.9 9.9 3.2 7.1 9.9 1.3 1 0 0 1 1 1 0 SDA1 SPT2 PF08243.11 EDP43801.1 - 3.4 8.2 11.9 16 6.1 1.5 3.0 3 0 0 3 3 3 0 SPT2 chromatin protein OPT PF03169.15 EDP43802.1 - 7.5e-130 434.5 47.8 8.7e-130 434.2 47.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PDEase_II PF02112.15 EDP43803.1 - 5.8e-29 101.3 0.0 1e-28 100.5 0.0 1.4 1 1 0 1 1 1 1 cAMP phosphodiesterases class-II Glu_synthase PF01645.17 EDP43804.1 - 4.9e-156 519.5 0.0 8.8e-156 518.7 0.0 1.4 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.21 EDP43804.1 - 1.4e-147 491.8 0.0 2.1e-147 491.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 EDP43804.1 - 2.6e-108 361.8 0.1 5.6e-107 357.4 0.1 2.1 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EDP43804.1 - 3.5e-85 284.4 2.2 5.7e-85 283.7 2.2 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EDP43804.1 - 1.8e-25 89.8 0.0 2.6e-17 63.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EDP43804.1 - 2e-21 75.9 0.1 5e-21 74.6 0.1 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EDP43804.1 - 7.6e-09 35.7 0.0 4.3e-08 33.3 0.0 2.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EDP43804.1 - 1.6e-07 31.8 3.1 7e-05 23.3 0.2 4.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDP43804.1 - 4.5e-07 29.8 2.7 0.0015 18.2 0.6 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EDP43804.1 - 2.9e-06 26.9 0.0 5.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EDP43804.1 - 1.1e-05 24.8 1.0 0.03 13.6 0.0 3.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDP43804.1 - 4.8e-05 22.2 0.1 4.8e-05 22.2 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EDP43804.1 - 5.3e-05 22.7 0.1 0.00011 21.7 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDP43804.1 - 0.0001 21.5 0.8 0.00026 20.2 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain AdoHcyase_NAD PF00670.21 EDP43804.1 - 0.00021 21.4 0.9 0.83 9.7 0.3 2.7 2 0 0 2 2 2 2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 EDP43804.1 - 0.00031 21.1 0.1 0.82 10.1 0.1 2.7 2 0 0 2 2 2 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EDP43804.1 - 0.002 17.4 0.0 0.004 16.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EDP43804.1 - 0.0042 16.4 0.1 0.0096 15.2 0.1 1.5 1 0 0 1 1 1 1 Thi4 family NAD_Gly3P_dh_N PF01210.23 EDP43804.1 - 0.0059 16.6 0.0 0.024 14.6 0.0 2.0 2 0 0 2 2 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FMN_dh PF01070.18 EDP43804.1 - 0.013 14.6 0.8 0.14 11.1 0.9 2.3 2 0 0 2 2 2 0 FMN-dependent dehydrogenase AlaDh_PNT_C PF01262.21 EDP43804.1 - 0.034 13.4 0.5 5.8 6.1 0.1 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 EDP43804.1 - 0.038 13.1 0.3 0.24 10.4 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EDP43804.1 - 0.055 13.4 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDP43804.1 - 0.055 12.8 0.0 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMO-like PF00743.19 EDP43804.1 - 0.16 10.4 0.4 1.8 6.9 0.0 2.6 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like GIDA PF01134.22 EDP43804.1 - 0.31 10.1 4.5 0.067 12.3 0.1 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Prp31_C PF09785.9 EDP43806.1 - 1.8e-39 135.4 3.5 1.8e-39 135.4 3.5 1.6 2 0 0 2 2 2 1 Prp31 C terminal domain Nop PF01798.18 EDP43806.1 - 1.8e-36 125.8 0.3 1.8e-36 125.8 0.3 1.6 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Adenylsucc_synt PF00709.21 EDP43807.1 - 7.5e-172 572.0 0.0 8.5e-172 571.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase CybS PF05328.12 EDP43808.1 - 1.5e-34 118.5 0.1 6.6e-32 110.0 0.0 2.2 2 0 0 2 2 2 2 CybS, succinate dehydrogenase cytochrome B small subunit TFIIS_C PF01096.18 EDP43809.1 - 1.3e-08 34.5 3.0 1.3e-08 34.5 3.0 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) T4_baseplate PF12322.8 EDP43809.1 - 0.014 14.9 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 T4 bacteriophage base plate protein Lar_restr_allev PF14354.6 EDP43809.1 - 0.048 14.1 1.1 0.067 13.6 1.1 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar CpXC PF14353.6 EDP43809.1 - 0.18 11.9 2.6 0.25 11.4 1.0 1.8 1 1 1 2 2 2 0 CpXC protein E1_dh PF00676.20 EDP43810.1 - 6.9e-109 363.4 0.0 7.8e-109 363.2 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EDP43810.1 - 0.0073 15.6 0.1 0.014 14.6 0.0 1.5 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Pribosyltran PF00156.27 EDP43811.1 - 6.1e-07 29.1 0.0 2.1e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain DUF962 PF06127.11 EDP43812.1 - 5.6e-22 77.6 1.2 2.2e-21 75.7 1.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Calici_coat_C PF08435.11 EDP43812.1 - 0.025 14.1 0.7 0.048 13.2 0.7 1.4 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal DUF974 PF06159.13 EDP43813.1 - 7.5e-35 120.9 0.0 1.1e-34 120.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Tti2 PF10521.9 EDP43814.1 - 4.6e-14 52.6 0.1 5.7e-12 45.7 0.1 2.3 1 1 0 1 1 1 1 Tti2 family zf-C3HC4_3 PF13920.6 EDP43815.1 - 2.1e-06 27.5 6.9 2.1e-06 27.5 6.9 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.26 EDP43815.1 - 3.8 8.1 28.9 0.98 10.0 2.7 6.2 6 1 0 6 6 6 0 Zinc finger, C2H2 type UPF0020 PF01170.18 EDP43816.1 - 7.1e-08 32.4 0.1 8.8e-06 25.5 0.1 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EDP43816.1 - 0.015 15.0 0.1 0.87 9.2 0.0 2.5 2 1 0 2 2 2 0 DNA methylase N6_Mtase PF02384.16 EDP43816.1 - 0.11 11.7 0.0 0.66 9.2 0.0 1.9 1 1 0 1 1 1 0 N-6 DNA Methylase DNA_ligase_A_M PF01068.21 EDP43817.1 - 2e-10 40.7 0.0 2.8e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 ATP dependent DNA ligase domain Mito_carr PF00153.27 EDP43818.1 - 0.0053 16.6 1.6 0.33 10.9 0.5 3.5 3 1 0 3 3 3 2 Mitochondrial carrier protein V-ATPase_H_N PF03224.14 EDP43819.1 - 3.8e-56 190.7 1.0 5e-55 187.0 0.1 2.1 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EDP43819.1 - 9.7e-34 116.0 0.5 3.5e-33 114.2 0.4 2.0 2 0 0 2 2 2 1 V-ATPase subunit H ACC_central PF08326.12 EDP43819.1 - 0.0042 15.4 0.3 0.0063 14.8 0.3 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region FUSC-like PF12805.7 EDP43819.1 - 0.011 14.8 0.7 0.17 10.9 0.3 2.2 1 1 1 2 2 2 0 FUSC-like inner membrane protein yccS Ric8 PF10165.9 EDP43819.1 - 0.069 12.2 0.9 0.16 10.9 0.1 1.8 1 1 1 2 2 2 0 Guanine nucleotide exchange factor synembryn VHS PF00790.19 EDP43819.1 - 0.1 12.4 0.4 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 VHS domain MRP-L46 PF11788.8 EDP43820.1 - 3.3e-17 63.3 0.0 6.1e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 CBS PF00571.28 EDP43821.1 - 2.7e-16 59.7 2.5 0.00014 22.2 0.1 5.5 5 1 0 5 5 5 5 CBS domain Ubiq_cyt_C_chap PF03981.12 EDP43822.1 - 2.9e-29 102.0 0.0 5.3e-26 91.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquinol-cytochrome C chaperone His_biosynth PF00977.21 EDP43823.1 - 2.9e-15 56.3 0.0 4.7e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein Nic96 PF04097.14 EDP43824.1 - 4e-172 573.9 0.6 5.3e-172 573.5 0.6 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Pkinase PF00069.25 EDP43825.1 - 5.3e-41 140.7 0.1 6.3e-21 74.9 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43825.1 - 1.4e-10 41.0 0.2 1.1e-07 31.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Rsa3 PF14615.6 EDP43826.1 - 3.9e-07 29.5 1.1 4.1e-06 26.3 1.1 2.2 1 1 0 1 1 1 1 Ribosome-assembly protein 3 Sperm_Ag_HE2 PF05324.13 EDP43826.1 - 0.18 12.3 1.7 0.94 10.0 0.1 2.7 3 0 0 3 3 3 0 Sperm antigen HE2 Glucosamine_iso PF01182.20 EDP43827.1 - 4e-32 111.9 0.0 4.4e-32 111.8 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2617 PF10936.8 EDP43827.1 - 0.08 13.0 0.0 0.41 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF2617 tRNA-synt_2b PF00587.25 EDP43828.1 - 9.6e-36 123.4 0.0 2.6e-35 122.0 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EDP43828.1 - 5.3e-08 32.9 0.0 5.6e-07 29.6 0.0 2.3 1 1 0 1 1 1 1 Anticodon binding domain Nse4_C PF08743.10 EDP43829.1 - 1.7e-17 63.5 0.0 3.5e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EDP43829.1 - 7.9e-10 38.7 0.3 1.8e-09 37.5 0.3 1.6 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Sec15 PF04091.12 EDP43830.1 - 1.1e-94 317.4 5.0 1.1e-94 317.4 5.0 2.0 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like Sec8_exocyst PF04048.14 EDP43830.1 - 1.5e-06 28.1 6.5 1.5e-06 28.1 6.5 3.2 2 1 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps51 PF08700.11 EDP43830.1 - 0.00027 21.0 3.4 0.00034 20.6 0.7 2.7 2 1 0 2 2 1 1 Vps51/Vps67 MnmE_helical PF12631.7 EDP43830.1 - 0.0017 18.6 5.5 0.0055 16.9 4.1 2.4 2 0 0 2 2 2 1 MnmE helical domain COG5 PF10392.9 EDP43830.1 - 0.0025 18.0 2.9 0.013 15.7 2.2 2.6 2 0 0 2 2 2 1 Golgi transport complex subunit 5 COG2 PF06148.11 EDP43830.1 - 0.0028 17.7 12.6 0.039 14.0 7.1 3.4 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 ImmE5 PF11480.8 EDP43830.1 - 0.077 13.5 0.1 0.4 11.2 0.1 2.0 2 0 0 2 2 2 0 Colicin-E5 Imm protein HCV_NS5a PF01506.19 EDP43830.1 - 0.57 10.1 2.0 1.4 8.9 0.5 2.4 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a protein membrane anchor Sec5 PF15469.6 EDP43830.1 - 0.62 9.9 9.7 0.33 10.7 6.0 2.5 2 1 0 2 2 2 0 Exocyst complex component Sec5 Vps53_N PF04100.12 EDP43830.1 - 1.7 7.5 14.7 0.076 12.0 5.7 2.5 3 0 0 3 3 3 0 Vps53-like, N-terminal PCRF PF03462.18 EDP43830.1 - 2.5 7.9 13.0 2.5 7.9 2.8 3.0 2 1 1 3 3 3 0 PCRF domain HypF_C PF17788.1 EDP43830.1 - 3.7 8.3 4.7 43 4.9 0.4 3.3 4 0 0 4 4 2 0 HypF Kae1-like domain ATG16 PF08614.11 EDP43830.1 - 7.9 6.7 13.5 0.45 10.7 8.0 1.7 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) DEAD PF00270.29 EDP43831.1 - 3.2e-44 150.8 0.0 1.5e-43 148.6 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43831.1 - 1.3e-28 99.5 0.2 1.2e-27 96.4 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP43831.1 - 0.0002 21.4 0.0 0.00068 19.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDP43831.1 - 0.035 13.3 0.1 0.061 12.5 0.1 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-CCHC_4 PF14392.6 EDP43831.1 - 0.17 11.7 1.2 0.39 10.5 1.2 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF2285 PF10074.9 EDP43831.1 - 0.82 10.4 7.2 0.18 12.5 2.0 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2285) Arf PF00025.21 EDP43832.1 - 6.4e-74 247.2 0.0 7.8e-74 246.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP43832.1 - 7.8e-15 55.2 0.0 1e-14 54.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDP43832.1 - 1.4e-12 47.4 0.0 1.7e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EDP43832.1 - 1.2e-11 44.5 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EDP43832.1 - 1.6e-11 44.0 0.3 2e-07 30.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EDP43832.1 - 1.2e-09 37.9 0.0 1.5e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EDP43832.1 - 7.3e-06 26.0 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MobB PF03205.14 EDP43832.1 - 0.0095 15.8 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 EDP43832.1 - 0.11 12.0 0.1 0.16 11.5 0.1 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B 6PF2K PF01591.18 EDP43832.1 - 0.13 11.6 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase CAP_GLY PF01302.25 EDP43833.1 - 3.6e-24 84.6 0.2 5.5e-24 84.0 0.2 1.3 1 0 0 1 1 1 1 CAP-Gly domain Dynactin PF12455.8 EDP43833.1 - 1.2e-14 54.3 4.1 1.2e-14 54.3 4.1 3.7 3 1 0 4 4 4 1 Dynein associated protein HOOK PF05622.12 EDP43833.1 - 5.9 4.9 46.8 5.1 5.1 1.1 2.5 2 0 0 2 2 2 0 HOOK protein DUF4988 PF16378.5 EDP43833.1 - 7.5 6.2 9.3 6.2 6.4 0.7 3.5 3 1 1 4 4 4 0 Domain of unknown function DUF1359 PF07097.11 EDP43833.1 - 7.6 6.8 9.9 13 6.1 0.7 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1359) Lon_C PF05362.13 EDP43834.1 - 4.8e-63 212.4 0.0 1e-62 211.3 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 EDP43834.1 - 1e-23 84.2 0.0 2.4e-23 83.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EDP43834.1 - 1.3e-09 38.2 0.0 4.4e-09 36.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EDP43834.1 - 2.7e-08 33.7 0.0 6.9e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EDP43834.1 - 4.9e-06 27.0 0.5 4.5e-05 23.9 0.1 2.6 2 1 1 3 3 2 1 AAA ATPase domain DUF815 PF05673.13 EDP43834.1 - 2.6e-05 23.5 0.0 0.022 13.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDP43834.1 - 0.00022 21.5 0.1 0.0039 17.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP43834.1 - 0.00037 20.7 0.1 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_PrkA PF08298.11 EDP43834.1 - 0.0026 16.7 0.0 0.0043 16.0 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain LON_substr_bdg PF02190.16 EDP43834.1 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_3 PF07726.11 EDP43834.1 - 0.01 15.7 0.1 0.17 11.7 0.0 2.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDP43834.1 - 0.012 15.1 0.1 0.067 12.6 0.1 2.2 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EDP43834.1 - 0.012 15.3 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDP43834.1 - 0.016 14.5 0.2 0.037 13.3 0.0 1.6 2 0 0 2 2 1 0 Zeta toxin RuvB_N PF05496.12 EDP43834.1 - 0.018 14.8 0.1 0.082 12.7 0.0 2.1 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDP43834.1 - 0.019 15.5 0.0 0.043 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EDP43834.1 - 0.037 13.6 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EDP43834.1 - 0.041 14.0 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EDP43834.1 - 0.048 13.4 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.6 EDP43834.1 - 0.055 13.8 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDP43834.1 - 0.058 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EDP43834.1 - 0.065 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain CPT PF07931.12 EDP43834.1 - 0.076 12.8 0.0 0.21 11.4 0.0 1.7 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein RNA_helicase PF00910.22 EDP43834.1 - 0.083 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EDP43834.1 - 0.084 12.8 0.0 0.46 10.4 0.0 2.1 1 1 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 EDP43834.1 - 0.086 12.6 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 EDP43834.1 - 0.092 13.0 2.0 0.16 12.2 0.0 2.4 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EDP43834.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EDP43834.1 - 0.1 12.6 0.0 0.6 10.1 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EDP43834.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EDP43834.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain PhoH PF02562.16 EDP43834.1 - 0.14 11.6 0.0 0.38 10.2 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 EDP43834.1 - 0.18 12.3 0.0 0.43 11.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter tRNA-synt_1c PF00749.21 EDP43835.1 - 6.4e-85 284.8 0.0 7.8e-85 284.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Nkap_C PF06047.11 EDP43836.1 - 4.5e-45 151.9 5.5 5.3e-45 151.7 5.5 1.0 1 0 0 1 1 1 1 NF-kappa-B-activating protein C-terminal domain eIF-5_eIF-2B PF01873.17 EDP43837.1 - 1.6e-39 134.4 0.0 2.6e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EDP43837.1 - 2.2e-21 75.8 0.1 2.2e-21 75.8 0.1 2.4 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Sigma70_ner PF04546.13 EDP43837.1 - 3.6e-06 27.0 0.1 0.22 11.4 0.0 2.6 2 1 0 2 2 2 2 Sigma-70, non-essential region End3 PF12761.7 EDP43837.1 - 0.072 13.3 0.3 0.072 13.3 0.3 1.8 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DNA_RNApol_7kD PF03604.13 EDP43837.1 - 0.096 12.4 3.1 0.18 11.5 3.1 1.4 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Pox_Ag35 PF03286.14 EDP43837.1 - 2.5 7.8 15.5 5 6.9 7.9 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein TRAPP PF04051.16 EDP43838.1 - 6.6e-30 103.7 0.0 8e-30 103.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ribonuc_2-5A PF06479.12 EDP43839.1 - 3.6e-42 143.5 0.1 7.7e-42 142.5 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 EDP43839.1 - 3.2e-40 138.1 0.0 4.8e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43839.1 - 1.3e-23 83.6 0.0 2.1e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 EDP43839.1 - 9.2e-06 25.3 0.0 8.9e-05 22.2 0.0 2.6 2 0 0 2 2 2 1 PQQ enzyme repeat Pkinase_fungal PF17667.1 EDP43839.1 - 3.9e-05 22.6 0.0 0.00025 19.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase PQQ_2 PF13360.6 EDP43839.1 - 0.00011 21.9 0.0 0.0079 15.8 0.0 2.8 3 0 0 3 3 3 1 PQQ-like domain APH PF01636.23 EDP43839.1 - 0.005 16.8 0.3 0.019 14.9 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP43839.1 - 0.005 16.2 0.0 0.0095 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ArsA_ATPase PF02374.15 EDP43840.1 - 4e-107 357.9 0.0 4.6e-107 357.7 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EDP43840.1 - 4.2e-13 49.6 0.0 1.2e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EDP43840.1 - 2.6e-12 46.9 0.0 1.4e-11 44.5 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EDP43840.1 - 1.6e-05 24.5 0.1 5.9e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EDP43840.1 - 2.1e-05 24.1 1.3 0.00018 21.1 0.5 2.4 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 EDP43840.1 - 7.2e-05 22.4 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 EDP43840.1 - 0.00033 20.3 0.0 0.0016 18.1 0.0 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 EDP43840.1 - 0.0026 17.3 0.1 0.14 11.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EDP43840.1 - 0.0054 16.2 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein MipZ PF09140.11 EDP43840.1 - 0.099 11.9 0.1 0.8 8.9 0.1 2.2 2 1 0 2 2 2 0 ATPase MipZ AAA_24 PF13479.6 EDP43840.1 - 0.19 11.5 0.0 0.62 9.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Acetyltransf_1 PF00583.25 EDP43841.1 - 1.1e-10 41.7 0.0 1.4e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EDP43841.1 - 9.3e-09 35.6 0.0 1.9e-08 34.6 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EDP43841.1 - 3.2e-08 33.6 0.1 5.3e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EDP43841.1 - 5.5e-06 26.3 0.0 9e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EDP43841.1 - 0.00087 19.4 0.3 0.0018 18.3 0.3 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Atg14 PF10186.9 EDP43842.1 - 1.3e-07 31.1 8.9 4.4e-07 29.3 8.9 1.9 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 EDP43842.1 - 0.061 12.9 0.8 0.083 12.5 0.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CDC45 PF02724.14 EDP43843.1 - 2.8e-216 719.7 0.0 3.2e-216 719.5 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein NESP55 PF06390.12 EDP43843.1 - 0.0084 15.7 4.9 0.015 14.9 4.9 1.4 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) SAGA-Tad1 PF12767.7 EDP43843.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit GHMP_kinases_N PF00288.26 EDP43843.1 - 0.033 14.4 0.2 0.14 12.4 0.2 2.2 1 0 0 1 1 1 0 GHMP kinases N terminal domain Trypan_PARP PF05887.11 EDP43843.1 - 6 6.9 9.3 1.9 8.5 5.0 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SNF2_N PF00176.23 EDP43844.1 - 2.4e-71 240.3 1.0 4.7e-71 239.3 1.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.13 EDP43844.1 - 3.3e-20 72.2 8.6 4.8e-20 71.7 6.5 2.4 2 0 0 2 2 2 1 HSA ResIII PF04851.15 EDP43844.1 - 1.4e-09 38.2 0.1 4.2e-09 36.7 0.1 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit QLQ PF08880.11 EDP43844.1 - 1.7e-08 34.1 0.4 8.1e-08 31.9 0.4 2.3 1 0 0 1 1 1 1 QLQ SWI2_SNF2 PF18766.1 EDP43844.1 - 7e-05 22.6 0.0 0.00018 21.2 0.0 1.7 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Bromodomain PF00439.25 EDP43845.1 - 1.5e-17 63.4 0.0 2.9e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 EDP43845.1 - 2.2e-16 60.1 0.1 5.7e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 EDP43845.1 - 2.8e-12 47.0 0.2 2.8e-12 47.0 0.2 3.9 3 1 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex TraD PF06412.11 EDP43845.1 - 0.085 12.7 0.4 0.085 12.7 0.4 2.6 3 0 0 3 3 3 0 Conjugal transfer protein TraD HNF-1_N PF04814.13 EDP43845.1 - 1 9.9 15.6 0.62 10.7 0.1 3.1 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Usp PF00582.26 EDP43846.1 - 1.2e-16 61.5 0.0 1.8e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family Ribosomal_L3 PF00297.22 EDP43847.1 - 2.9e-160 533.3 9.2 3.3e-160 533.1 9.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 zf-HC5HC2H_2 PF13832.6 EDP43848.1 - 3.4e-19 69.0 7.7 3.4e-19 69.0 7.7 4.9 5 0 0 5 5 5 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDP43848.1 - 5.2e-16 58.7 6.7 5.2e-16 58.7 6.7 4.8 5 0 0 5 5 5 2 PHD-like zinc-binding domain PHD PF00628.29 EDP43848.1 - 9.2e-15 54.3 19.5 9.8e-09 35.0 6.7 5.9 7 0 0 7 7 7 2 PHD-finger BAH PF01426.18 EDP43848.1 - 4.4e-13 49.1 0.0 8.8e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 BAH domain PHD_2 PF13831.6 EDP43848.1 - 6.1e-06 25.7 0.7 6.1e-06 25.7 0.7 5.1 5 0 0 5 5 5 2 PHD-finger GATA PF00320.27 EDP43848.1 - 0.001 18.6 13.1 0.051 13.2 0.3 3.7 3 0 0 3 3 3 2 GATA zinc finger DUF778 PF05608.12 EDP43848.1 - 0.0084 16.5 0.1 0.02 15.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF778) Sugar_tr PF00083.24 EDP43850.1 - 5.1e-121 404.7 11.1 6.3e-121 404.4 11.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP43850.1 - 8.6e-26 90.7 34.7 7.1e-24 84.4 16.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tetraspanin PF00335.20 EDP43850.1 - 5.8 6.6 9.3 1.1e+02 2.3 8.2 3.4 2 1 0 2 2 2 0 Tetraspanin family DUF2530 PF10745.9 EDP43850.1 - 9.7 6.5 8.6 0.49 10.7 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) RRM_1 PF00076.22 EDP43851.1 - 1.1e-33 114.9 0.0 4.1e-17 61.8 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP43851.1 - 9e-06 25.3 0.0 0.00028 20.5 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP43851.1 - 0.023 14.8 0.0 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif Limkain-b1 PF11608.8 EDP43851.1 - 0.057 13.5 0.1 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Limkain b1 PHM7_cyt PF14703.6 EDP43851.1 - 0.21 11.8 0.0 11 6.2 0.0 2.2 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Per1 PF04080.13 EDP43852.1 - 1e-82 277.8 3.8 1e-82 277.8 3.8 1.4 2 0 0 2 2 2 1 Per1-like family PalH PF08733.10 EDP43852.1 - 2.5 7.0 9.4 3.8 6.4 6.6 2.3 2 1 0 2 2 2 0 PalH/RIM21 eIF3_subunit PF08597.10 EDP43853.1 - 2.9e-42 145.3 22.5 3.3e-42 145.1 22.5 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Neur_chan_memb PF02932.16 EDP43853.1 - 6.5 6.7 4.8 1.8 8.6 2.0 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region tRNA-synt_1 PF00133.22 EDP43854.1 - 4.3e-140 467.8 0.0 6.2e-140 467.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EDP43854.1 - 2.4e-18 66.1 0.0 1.5e-11 43.7 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EDP43854.1 - 2.7e-17 63.1 0.0 4.8e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EDP43854.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.14 EDP43854.1 - 0.061 13.2 2.8 0.16 11.9 2.8 1.8 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Pox_MCEL PF03291.16 EDP43855.1 - 7.5e-69 232.4 0.0 9.5e-69 232.0 0.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EDP43855.1 - 1.1e-14 54.8 0.0 2e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP43855.1 - 1.8e-09 38.1 0.0 4.1e-09 37.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP43855.1 - 3.5e-09 36.6 0.0 5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43855.1 - 6.7e-08 33.2 0.0 1.6e-07 32.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP43855.1 - 1.6e-07 31.3 0.0 2.6e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EDP43855.1 - 0.00052 19.3 0.0 0.00085 18.6 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family MTS PF05175.14 EDP43855.1 - 0.021 14.4 0.0 0.044 13.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Mak10 PF04112.13 EDP43856.1 - 1.3e-28 99.7 0.1 6.4e-28 97.4 0.1 2.1 1 1 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PIG-U PF06728.13 EDP43857.1 - 4.6e-09 35.8 0.1 5.4e-09 35.6 0.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mo25 PF08569.11 EDP43858.1 - 1.2e-97 327.2 1.7 1.4e-97 327.1 1.7 1.0 1 0 0 1 1 1 1 Mo25-like V-ATPase_H_N PF03224.14 EDP43858.1 - 0.0033 16.8 0.1 0.013 14.8 0.2 1.8 2 0 0 2 2 2 1 V-ATPase subunit H HEAT_2 PF13646.6 EDP43858.1 - 0.15 12.4 0.0 0.55 10.7 0.0 1.9 1 1 0 1 1 1 0 HEAT repeats Adaptin_N PF01602.20 EDP43859.1 - 1.7e-138 462.5 9.5 2e-138 462.2 9.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EDP43859.1 - 2e-15 57.0 0.0 4.1e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EDP43859.1 - 2.3e-06 27.7 10.0 3.5e-05 23.9 0.4 3.8 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDP43859.1 - 0.00091 19.6 0.6 8.3 6.9 0.0 4.5 4 2 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EDP43859.1 - 0.02 15.1 0.5 40 4.8 0.0 4.8 4 0 0 4 4 4 0 HEAT repeat RIX1 PF08167.12 EDP43859.1 - 0.037 13.8 2.5 0.9 9.2 0.2 3.5 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis TIP120 PF08623.10 EDP43859.1 - 0.16 11.8 8.2 0.73 9.6 0.2 3.8 3 2 2 5 5 5 0 TATA-binding protein interacting (TIP20) Vac14_Fab1_bd PF12755.7 EDP43859.1 - 0.46 11.1 2.6 16 6.1 0.1 3.8 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region SPO11_like PF03533.14 EDP43859.1 - 0.59 10.3 6.2 6 7.0 0.4 3.2 3 0 0 3 3 3 0 SPO11 homologue V-ATPase_H_C PF11698.8 EDP43859.1 - 0.89 9.7 6.0 31 4.7 0.3 4.0 3 1 1 4 4 4 0 V-ATPase subunit H MFS_1 PF07690.16 EDP43860.1 - 1.9e-12 46.8 20.4 1.9e-12 46.8 20.4 3.1 2 1 1 3 3 3 2 Major Facilitator Superfamily OATP PF03137.20 EDP43860.1 - 0.0075 14.6 9.5 0.035 12.4 0.3 2.7 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family UPF1_Zn_bind PF09416.10 EDP43861.1 - 7.4e-68 227.3 4.0 1e-67 226.8 1.2 2.2 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EDP43861.1 - 2.3e-57 193.9 0.0 8.1e-57 192.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EDP43861.1 - 2.1e-51 175.2 12.5 2.1e-30 106.4 0.6 3.6 2 1 1 3 3 3 2 AAA domain DUF5599 PF18141.1 EDP43861.1 - 5.5e-21 74.6 0.0 1.1e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EDP43861.1 - 1.6e-15 57.3 0.0 4.5e-14 52.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDP43861.1 - 2.7e-12 47.3 0.4 2.4e-11 44.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EDP43861.1 - 5.3e-07 29.8 0.9 3.8e-06 27.0 0.0 2.5 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EDP43861.1 - 4.2e-06 26.5 4.8 0.032 13.8 0.1 3.4 2 2 1 3 3 3 2 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 EDP43861.1 - 9.5e-06 25.6 0.1 3.7e-05 23.7 0.1 2.1 1 1 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 EDP43861.1 - 2e-05 24.4 0.5 0.56 9.9 0.0 3.4 4 0 0 4 4 3 2 Viral (Superfamily 1) RNA helicase SRP54 PF00448.22 EDP43861.1 - 0.00041 20.0 0.0 0.046 13.3 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain DUF2075 PF09848.9 EDP43861.1 - 0.0023 17.2 0.2 0.0023 17.2 0.2 3.2 4 1 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDP43861.1 - 0.0072 16.6 0.2 0.16 12.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 EDP43861.1 - 0.0094 16.5 0.1 0.28 11.7 0.1 2.6 2 0 0 2 2 2 1 ABC transporter DEAD PF00270.29 EDP43861.1 - 0.012 15.4 1.2 0.046 13.5 0.6 2.3 2 1 0 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.16 EDP43861.1 - 0.019 14.4 0.0 0.047 13.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 EDP43861.1 - 0.043 14.2 0.1 0.18 12.2 0.1 2.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EDP43861.1 - 0.061 13.3 0.1 0.45 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.7 EDP43861.1 - 0.08 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 EDP43861.1 - 0.15 11.4 0.0 0.46 9.8 0.0 1.8 1 0 0 1 1 1 0 KaiC AAA PF00004.29 EDP43861.1 - 0.16 12.4 0.1 0.56 10.6 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.14 EDP43861.1 - 0.17 11.8 0.8 0.82 9.6 0.2 2.4 2 1 1 3 3 3 0 Flavivirus DEAD domain AMP-binding PF00501.28 EDP43862.1 - 6.6e-73 245.7 0.0 7.8e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDP43862.1 - 9.6e-15 55.3 0.0 3.8e-14 53.4 0.0 2.1 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain AAA_2 PF07724.14 EDP43862.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) MoCF_biosynth PF00994.24 EDP43864.1 - 2.8e-33 114.6 0.0 3.9e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain Ysc84 PF04366.12 EDP43865.1 - 1.1e-37 128.6 0.6 1.8e-37 128.0 0.6 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EDP43865.1 - 4.5e-10 39.0 0.1 8.6e-10 38.1 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP43865.1 - 8e-09 35.2 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP43865.1 - 5.4e-08 32.4 0.0 9.3e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.25 EDP43866.1 - 1.3e-10 41.1 0.0 3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain RWD PF05773.22 EDP43866.1 - 4.9e-10 39.7 1.1 5.6e-10 39.5 0.0 1.6 2 0 0 2 2 2 1 RWD domain DUF2570 PF10828.8 EDP43866.1 - 1.2 9.0 6.4 14 5.6 5.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DUF3682 PF12446.8 EDP43866.1 - 1.6 9.2 6.9 2.9 8.4 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Pkinase PF00069.25 EDP43867.1 - 1.5e-38 132.7 0.0 2.6e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HGTP_anticodon2 PF12745.7 EDP43867.1 - 3e-26 92.5 0.0 1.4e-25 90.3 0.0 1.9 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase_Tyr PF07714.17 EDP43867.1 - 5.5e-18 65.2 0.0 1.4e-17 63.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase tRNA-synt_His PF13393.6 EDP43867.1 - 1.1e-15 57.8 0.0 1.8e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase Haspin_kinase PF12330.8 EDP43867.1 - 0.0012 17.8 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP43867.1 - 0.0013 18.7 3.7 0.0015 18.5 0.1 2.8 4 0 0 4 4 4 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP43867.1 - 0.009 14.8 0.3 0.016 14.0 0.3 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP43867.1 - 0.082 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Ank_4 PF13637.6 EDP43868.1 - 6.4e-13 48.9 0.2 3.6e-10 40.2 0.2 2.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EDP43868.1 - 5.8e-11 42.4 0.4 4.6e-08 33.2 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDP43868.1 - 1.4e-10 41.6 0.0 3.4e-10 40.4 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP43868.1 - 9.4e-07 28.7 0.1 0.0011 19.2 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EDP43868.1 - 2.6e-06 27.6 0.3 0.00017 21.8 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat Methyltransf_25 PF13649.6 EDP43868.1 - 0.072 13.8 0.0 0.24 12.1 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Nucleoporin_FG PF13634.6 EDP43869.1 - 4.2e-30 104.4 151.2 1.8e-12 48.0 33.4 4.3 1 1 3 4 4 4 4 Nucleoporin FG repeat region Nucleoporin_FG2 PF15967.5 EDP43869.1 - 1.5e-06 27.1 6.4 1.5e-06 27.1 6.4 4.2 2 1 2 4 4 4 2 Nucleoporin FG repeated region LPP PF04728.13 EDP43869.1 - 0.081 13.3 1.0 6.6 7.2 0.0 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ABC_tran PF00005.27 EDP43870.1 - 3.8e-31 108.4 0.0 5.5e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDP43870.1 - 2.6e-21 76.5 2.5 3.5e-21 76.1 2.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDP43870.1 - 0.0015 18.0 0.2 0.028 13.9 0.0 1.9 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EDP43870.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 EDP43870.1 - 0.038 13.7 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EDP43870.1 - 0.059 13.6 0.1 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP43870.1 - 0.068 13.5 0.1 0.36 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 EDP43870.1 - 0.18 10.9 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 EDP43870.1 - 0.47 10.2 0.0 0.47 10.2 0.0 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain ABC_membrane PF00664.23 EDP43871.1 - 4.3e-30 105.3 12.2 4.9e-30 105.1 9.5 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EDP43871.1 - 9.2e-28 97.5 0.0 1.2e-26 93.9 0.0 2.3 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EDP43871.1 - 7.2e-08 32.1 0.1 0.00045 19.7 0.0 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP43871.1 - 0.0004 20.1 0.1 0.001 18.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 EDP43871.1 - 0.0005 20.1 0.0 0.029 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EDP43871.1 - 0.00075 20.1 0.0 0.0015 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EDP43871.1 - 0.0015 18.1 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_ATPase PF09818.9 EDP43871.1 - 0.0031 16.4 0.1 0.016 14.0 0.0 2.1 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_18 PF13238.6 EDP43871.1 - 0.0036 17.9 0.0 0.021 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDP43871.1 - 0.0042 17.4 0.0 0.077 13.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDP43871.1 - 0.0074 16.0 0.0 0.012 15.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EDP43871.1 - 0.013 15.1 0.1 0.077 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF4383 PF14325.6 EDP43871.1 - 0.016 15.4 0.8 0.016 15.4 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4383) AAA_16 PF13191.6 EDP43871.1 - 0.019 15.4 0.2 0.048 14.0 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 EDP43871.1 - 0.022 14.7 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EDP43871.1 - 0.023 14.6 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 EDP43871.1 - 0.031 14.1 0.0 0.33 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SNF2_N PF00176.23 EDP43872.1 - 1.6e-59 201.4 0.4 3.6e-58 196.9 0.0 2.3 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP43872.1 - 5e-20 71.9 0.0 1.1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EDP43872.1 - 0.0063 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EDP43872.1 - 0.13 12.2 0.2 1.4 8.9 0.2 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Auto_anti-p27 PF06677.12 EDP43872.1 - 3 8.1 7.3 0.082 13.1 0.8 1.9 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EDP43872.1 - 10 6.3 8.2 0.38 10.8 2.1 1.7 2 0 0 2 2 2 0 Double zinc ribbon HHH PF00633.23 EDP43873.1 - 0.0018 18.0 0.1 0.0034 17.2 0.1 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EDP43873.1 - 0.13 12.9 0.0 0.24 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain GLE1 PF07817.13 EDP43874.1 - 5.6e-73 245.2 0.1 9.6e-73 244.5 0.1 1.4 1 0 0 1 1 1 1 GLE1-like protein MIF4G_like_2 PF09090.11 EDP43874.1 - 0.036 13.5 7.5 0.046 13.2 5.7 2.0 2 0 0 2 2 2 0 MIF4G like DDHD PF02862.17 EDP43874.1 - 1.7 8.8 4.9 3.3 7.8 4.9 1.6 1 0 0 1 1 1 0 DDHD domain Nop53 PF07767.11 EDP43874.1 - 3.4 7.0 24.6 6 6.1 24.6 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF1682 PF07946.14 EDP43874.1 - 3.4 6.8 15.6 6.1 5.9 15.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) He_PIG PF05345.12 EDP43875.1 - 5.2e-09 36.1 1.5 0.0049 17.0 0.2 4.7 6 0 0 6 6 6 2 Putative Ig domain TRAPP PF04051.16 EDP43876.1 - 3.4e-35 120.9 0.0 4.6e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF111 PF01969.17 EDP43876.1 - 0.1 11.7 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF111 Aldedh PF00171.22 EDP43877.1 - 4.7e-105 351.8 0.0 5.6e-105 351.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BRCT_assoc PF12820.7 EDP43878.1 - 0.029 14.2 0.4 0.029 14.2 0.4 2.2 2 0 0 2 2 2 0 Serine-rich domain associated with BRCT NOG1_N PF17835.1 EDP43879.1 - 4e-20 72.4 0.1 4.9e-20 72.1 0.1 1.0 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EDP43880.1 - 6.7e-28 96.3 0.1 1.3e-27 95.3 0.1 1.5 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 EDP43880.1 - 1.6e-27 95.2 4.0 4e-27 94.0 4.0 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 EDP43880.1 - 2.3e-18 66.3 0.1 7.5e-18 64.7 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP43880.1 - 3e-09 36.6 0.0 5.2e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EDP43880.1 - 7.4e-06 26.1 1.7 0.6 10.1 0.0 3.5 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 EDP43880.1 - 0.0062 15.9 0.3 0.046 13.1 0.0 2.2 2 0 0 2 2 2 1 AIG1 family NOG1_N PF17835.1 EDP43880.1 - 0.011 15.7 0.0 0.011 15.7 0.0 2.3 2 0 0 2 2 2 0 NOG1 N-terminal helical domain Roc PF08477.13 EDP43880.1 - 0.018 15.2 0.0 0.16 12.2 0.0 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EDP43880.1 - 0.019 14.9 0.1 0.39 10.6 0.0 2.9 2 1 0 2 2 2 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EDP43880.1 - 0.028 14.4 0.0 0.065 13.3 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 EDP43880.1 - 0.066 13.6 0.3 0.8 10.1 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 EDP43880.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 Ras family DUF4532 PF15046.6 EDP43881.1 - 0.018 14.2 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) Hydrolase_4 PF12146.8 EDP43881.1 - 0.025 13.9 0.1 0.15 11.3 0.0 2.0 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DUF1749 PF08538.10 EDP43881.1 - 0.091 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Acetyltransf_7 PF13508.7 EDP43882.1 - 3.6e-06 27.3 0.0 4.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP43882.1 - 4e-06 27.0 0.0 5.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDP43882.1 - 0.00021 21.2 0.0 0.00026 20.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PAN_3 PF08277.12 EDP43882.1 - 0.035 13.9 0.5 0.057 13.2 0.5 1.3 1 0 0 1 1 1 0 PAN-like domain Acetyltransf_13 PF13880.6 EDP43882.1 - 0.14 12.1 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase CRAL_TRIO PF00650.20 EDP43883.1 - 6e-34 117.1 0.2 1e-33 116.3 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDP43883.1 - 1.7e-07 31.3 1.2 1.7e-07 31.3 1.2 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Ilar_coat PF01787.16 EDP43883.1 - 0.15 11.9 1.2 0.3 10.9 1.0 1.6 2 0 0 2 2 2 0 Ilarvirus coat protein zf-RING_2 PF13639.6 EDP43884.1 - 6.6e-14 52.0 1.2 6.6e-14 52.0 1.2 1.7 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 EDP43884.1 - 2.9e-11 42.9 0.4 7.2e-11 41.6 0.4 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDP43884.1 - 8.4e-10 38.3 0.8 1.5e-09 37.6 0.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP43884.1 - 9.7e-08 31.8 0.2 1.7e-07 31.1 0.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDP43884.1 - 1.9e-07 31.3 1.3 3.8e-07 30.3 0.4 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDP43884.1 - 8.9e-07 28.8 0.2 3.2e-06 27.1 0.2 1.9 1 1 1 2 2 2 1 RING-type zinc-finger PA PF02225.22 EDP43884.1 - 2.5e-06 27.4 0.0 4.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-C3HC4 PF00097.25 EDP43884.1 - 8.6e-06 25.5 0.1 1.8e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP43884.1 - 6.9e-05 22.6 0.6 0.00015 21.6 0.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDP43884.1 - 0.00019 21.4 0.7 0.00042 20.3 0.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDP43884.1 - 0.0014 18.5 2.0 0.026 14.4 2.3 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 TackOD1 PF18551.1 EDP43884.1 - 0.0037 17.0 0.1 0.0052 16.5 0.1 1.2 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 zf-Nse PF11789.8 EDP43884.1 - 0.006 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EDP43884.1 - 0.0097 15.7 1.6 0.018 14.8 1.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDP43884.1 - 0.012 15.7 3.4 0.035 14.3 1.5 2.6 2 1 0 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EDP43884.1 - 0.043 13.4 0.6 0.098 12.3 0.6 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Rtf2 PF04641.12 EDP43884.1 - 0.076 12.4 0.1 0.15 11.4 0.0 1.5 2 0 0 2 2 2 0 Rtf2 RING-finger Prok-RING_1 PF14446.6 EDP43884.1 - 0.17 11.9 3.0 0.42 10.6 0.5 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Aldedh PF00171.22 EDP43885.1 - 4.5e-151 503.5 0.2 5.1e-151 503.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RNase_H PF00075.24 EDP43886.1 - 0.006 16.8 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 RNase H DUF3552 PF12072.8 EDP43886.1 - 0.087 12.2 0.7 0.15 11.4 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) CHCH PF06747.13 EDP43887.1 - 0.0075 16.4 6.2 0.012 15.8 0.6 2.4 2 1 0 2 2 2 1 CHCH domain CX9C PF16860.5 EDP43887.1 - 0.013 15.5 5.5 1.7 8.7 1.3 2.2 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, ChaC PF04752.12 EDP43888.1 - 7.6e-50 169.4 0.0 1.5e-49 168.4 0.0 1.5 1 0 0 1 1 1 1 ChaC-like protein DnaJ PF00226.31 EDP43888.1 - 7.1e-23 80.5 1.5 2.1e-22 79.0 1.5 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 EDP43888.1 - 2.7e-09 37.1 1.3 4.9e-09 36.2 1.3 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDP43888.1 - 6.3e-08 32.8 1.8 1.2e-07 31.9 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDP43888.1 - 0.013 15.9 1.5 0.026 14.9 0.6 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EDP43888.1 - 0.087 12.8 1.0 0.18 11.8 1.0 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Methyltransf_16 PF10294.9 EDP43889.1 - 1.2e-16 60.9 0.0 1.9e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EDP43889.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EDP43889.1 - 0.099 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EDP43890.1 - 5e-33 114.7 0.5 7.6e-33 114.1 0.0 1.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EDP43890.1 - 0.0031 18.2 0.0 0.012 16.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Sugar_tr PF00083.24 EDP43891.1 - 1e-87 294.9 15.9 1.2e-87 294.6 15.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP43891.1 - 2.6e-15 56.2 27.1 2.6e-15 56.2 27.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 EDP43891.1 - 0.38 11.0 3.5 0.52 10.5 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) PhoD PF09423.10 EDP43892.1 - 3.4e-06 26.3 0.0 0.0017 17.4 0.0 2.5 3 0 0 3 3 3 2 PhoD-like phosphatase Pectate_lyase_3 PF12708.7 EDP43893.1 - 3.1e-09 37.0 0.0 3.3e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Pectate lyase superfamily protein Pectate_lyase_3 PF12708.7 EDP43894.1 - 1.1e-32 113.6 6.3 2.3e-18 66.8 0.9 2.1 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EDP43894.1 - 0.012 15.3 0.1 0.021 14.5 0.1 1.3 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase Cas_csx3 PF09620.10 EDP43895.1 - 0.18 11.7 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) GST_N PF02798.20 EDP43896.1 - 4.7e-10 39.7 0.0 8.6e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EDP43896.1 - 9.5e-09 35.4 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDP43896.1 - 5.5e-08 32.7 0.1 9.3e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EDP43896.1 - 5.8e-06 26.5 0.0 1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDP43896.1 - 0.00016 22.0 0.0 0.00034 21.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Phage_tail_APC PF16778.5 EDP43896.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Cyt-b5 PF00173.28 EDP43897.1 - 1.2e-16 60.6 0.0 1.8e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Arginase PF00491.21 EDP43898.1 - 2e-77 260.4 0.3 2.4e-77 260.2 0.3 1.0 1 0 0 1 1 1 1 Arginase family dCMP_cyt_deam_1 PF00383.23 EDP43899.1 - 1.2e-08 34.8 0.2 1.4e-08 34.5 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EDP43899.1 - 2.9e-08 33.5 0.0 3.1e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EDP43899.1 - 0.0074 16.4 0.0 0.0074 16.4 0.0 1.2 1 0 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 EDP43899.1 - 0.17 12.0 0.1 0.23 11.6 0.1 1.1 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 AAA PF00004.29 EDP43900.1 - 1.3e-90 300.7 0.0 2.3e-46 157.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP43900.1 - 4.3e-21 74.4 0.0 5.3e-09 35.7 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EDP43900.1 - 1.2e-13 51.1 0.0 4.9e-06 26.4 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDP43900.1 - 5.1e-11 43.3 4.9 0.002 18.5 0.0 4.8 3 2 1 4 4 4 2 AAA ATPase domain AAA_2 PF07724.14 EDP43900.1 - 2.4e-10 40.8 0.0 0.0015 18.7 0.0 3.0 3 1 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDP43900.1 - 3.5e-10 40.2 0.0 0.00033 20.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDP43900.1 - 8.2e-10 39.1 1.3 0.028 14.7 0.0 5.3 2 2 3 5 5 5 2 AAA domain AAA_5 PF07728.14 EDP43900.1 - 9.2e-10 38.7 0.6 0.0017 18.4 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EDP43900.1 - 6.3e-08 32.2 0.0 0.0017 17.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 EDP43900.1 - 3.8e-07 29.7 0.6 0.03 13.7 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EDP43900.1 - 8.3e-07 29.4 0.0 0.074 13.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EDP43900.1 - 1.5e-06 28.6 0.0 0.037 14.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EDP43900.1 - 5.9e-06 26.1 1.2 0.049 13.4 0.0 3.2 3 1 0 3 3 3 2 IstB-like ATP binding protein Cytidylate_kin2 PF13189.6 EDP43900.1 - 6.1e-06 26.5 0.0 0.0046 17.1 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_18 PF13238.6 EDP43900.1 - 7.1e-06 26.6 0.0 0.19 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 EDP43900.1 - 2e-05 24.4 0.0 0.093 12.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EDP43900.1 - 2e-05 24.6 0.0 0.025 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDP43900.1 - 3.3e-05 23.8 0.4 0.6 10.0 0.1 3.4 2 1 1 3 3 3 2 NACHT domain TsaE PF02367.17 EDP43900.1 - 4.1e-05 23.6 0.0 0.26 11.3 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EDP43900.1 - 5.1e-05 23.8 0.3 0.1 13.1 0.0 3.3 3 0 0 3 3 3 1 ABC transporter Rad17 PF03215.15 EDP43900.1 - 6.4e-05 23.0 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_7 PF12775.7 EDP43900.1 - 8.9e-05 22.1 0.0 0.4 10.2 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 EDP43900.1 - 0.00012 21.7 3.3 2.5 7.7 0.1 4.9 4 1 1 5 5 5 2 AAA domain ATPase PF06745.13 EDP43900.1 - 0.00026 20.4 0.1 1.9 7.8 0.0 3.2 3 0 0 3 3 3 1 KaiC Viral_helicase1 PF01443.18 EDP43900.1 - 0.00032 20.5 0.0 0.75 9.5 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EDP43900.1 - 0.00069 19.5 1.5 1.3 8.7 0.0 3.2 4 0 0 4 4 4 2 AAA domain AAA_17 PF13207.6 EDP43900.1 - 0.00071 20.0 3.8 0.29 11.6 0.1 3.4 3 1 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EDP43900.1 - 0.0015 18.2 0.0 0.37 10.5 0.0 3.3 3 1 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EDP43900.1 - 0.0023 18.0 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EDP43900.1 - 0.003 16.7 0.1 1.8 7.6 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 EDP43900.1 - 0.0053 16.0 0.1 0.66 9.1 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 EDP43900.1 - 0.0063 15.8 0.1 0.58 9.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin SKI PF01202.22 EDP43900.1 - 0.0078 16.3 0.1 5 7.2 0.0 2.9 2 0 0 2 2 2 0 Shikimate kinase DUF815 PF05673.13 EDP43900.1 - 0.012 14.7 0.0 0.037 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PhoH PF02562.16 EDP43900.1 - 0.013 14.9 0.4 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EDP43900.1 - 0.014 15.2 0.0 0.94 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 EDP43900.1 - 0.027 13.4 0.0 2.2 7.1 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase Vps4_C PF09336.10 EDP43900.1 - 0.047 13.7 0.0 9.9 6.2 0.0 3.0 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain ATPase_2 PF01637.18 EDP43900.1 - 0.059 13.3 0.0 2.2 8.2 0.0 3.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea ResIII PF04851.15 EDP43900.1 - 0.14 12.1 0.0 17 5.4 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Hydin_ADK PF17213.3 EDP43900.1 - 0.15 12.3 1.6 2.6 8.3 0.0 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain PduV-EutP PF10662.9 EDP43900.1 - 0.18 11.6 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EDP43900.1 - 2.4 7.8 4.4 22 4.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain P21-Arc PF04062.14 EDP43901.1 - 5.5e-75 251.2 0.0 6.1e-75 251.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit PCI PF01399.27 EDP43902.1 - 1.3e-12 48.1 0.0 7.3e-12 45.7 0.0 2.3 1 1 1 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EDP43902.1 - 4e-10 39.2 4.0 1.2e-09 37.7 4.0 1.9 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix TipAS PF07739.13 EDP43902.1 - 0.087 13.4 2.7 1.1 9.8 0.8 2.4 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain TFIIE_alpha PF02002.17 EDP43902.1 - 0.11 12.4 0.6 0.4 10.6 0.0 2.1 2 1 0 2 2 2 0 TFIIE alpha subunit DUF3319 PF11782.8 EDP43902.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) Sybindin PF04099.12 EDP43903.1 - 8.3e-37 126.3 0.0 9.2e-37 126.1 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EDP43903.1 - 1.6e-07 31.5 0.0 1.6e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region PTH2 PF01981.16 EDP43904.1 - 0.00076 19.8 0.0 0.00095 19.4 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 SAP18 PF06487.12 EDP43904.1 - 0.026 14.7 0.1 0.032 14.4 0.1 1.1 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) 2-Hacid_dh_C PF02826.19 EDP43905.1 - 2e-51 173.9 0.0 3.8e-51 173.0 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EDP43905.1 - 4.5e-18 65.2 0.0 1.7e-17 63.3 0.0 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EDP43905.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NIF PF03031.18 EDP43906.1 - 9.5e-35 119.7 0.0 1.4e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SPX PF03105.19 EDP43906.1 - 0.0086 16.0 0.0 0.0086 16.0 0.0 1.1 1 0 0 1 1 1 1 SPX domain Methyltransf_16 PF10294.9 EDP43907.1 - 1.5e-15 57.4 0.0 2.2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EDP43907.1 - 0.0022 18.6 0.1 0.0088 16.7 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP43907.1 - 0.003 18.3 0.0 0.0058 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP43907.1 - 0.0058 16.5 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EDP43907.1 - 0.041 13.4 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DUF43 PF01861.16 EDP43907.1 - 0.12 11.6 0.1 0.18 11.0 0.1 1.1 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain MRP-S28 PF10213.9 EDP43908.1 - 3e-23 82.6 0.0 6.3e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein RRP7 PF12923.7 EDP43909.1 - 7.7e-23 80.9 7.6 4.5e-22 78.4 7.6 2.0 1 1 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EDP43909.1 - 3.6e-12 46.4 0.0 1.5e-11 44.3 0.0 1.9 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 EDP43909.1 - 6.2e-07 29.1 0.0 3e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L14e PF01929.17 EDP43909.1 - 0.045 14.2 4.5 0.75 10.3 3.3 2.7 3 0 0 3 3 3 0 Ribosomal protein L14 MCM PF00493.23 EDP43910.1 - 1.3e-100 335.1 0.2 2.6e-100 334.2 0.2 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP43910.1 - 1.7e-38 131.3 1.3 3.2e-38 130.4 1.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDP43910.1 - 2e-26 92.2 0.7 4.5e-26 91.1 0.3 1.9 2 0 0 2 2 2 1 MCM AAA-lid domain MCM6_C PF18263.1 EDP43910.1 - 4e-24 84.9 0.7 9.8e-24 83.7 0.7 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 EDP43910.1 - 1.4e-17 64.2 0.1 3.3e-17 63.0 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDP43910.1 - 1.6e-08 34.2 0.0 5e-07 29.3 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EDP43910.1 - 0.00078 19.2 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EDP43910.1 - 0.0022 17.9 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Tir_receptor_M PF03549.14 EDP43910.1 - 0.035 14.4 0.0 0.094 13.1 0.0 1.7 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) intimin-binding domain AAA_5 PF07728.14 EDP43910.1 - 0.045 13.8 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Asp PF00026.23 EDP43912.1 - 1.2e-42 146.4 5.0 5.4e-42 144.3 5.0 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EDP43912.1 - 0.00013 21.8 0.1 0.00081 19.2 0.0 2.3 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EDP43912.1 - 0.00022 21.7 0.8 0.07 13.7 0.0 2.4 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDP43912.1 - 0.001 19.6 1.0 1.7 9.4 0.1 2.6 2 0 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 EDP43912.1 - 0.0085 16.3 0.0 2.1 8.6 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Cu-oxidase_2 PF07731.14 EDP43913.1 - 5.4e-26 91.0 0.6 6.4e-26 90.7 0.6 1.1 1 0 0 1 1 1 1 Multicopper oxidase LIP PF03583.14 EDP43914.1 - 1.4e-57 195.3 0.0 1.8e-57 194.9 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 EDP43914.1 - 0.0047 16.4 5.6 0.67 9.4 0.7 3.2 2 1 1 3 3 3 2 Prolyl oligopeptidase family tRNA_synthFbeta PF17759.1 EDP43914.1 - 0.087 12.3 0.0 0.34 10.3 0.0 1.9 2 0 0 2 2 2 0 Phenylalanyl tRNA synthetase beta chain CLM domain Abhydrolase_4 PF08386.10 EDP43914.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Hydrolase_4 PF12146.8 EDP43914.1 - 0.11 11.7 0.0 0.29 10.4 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 His_Phos_2 PF00328.22 EDP43915.1 - 1.4e-42 146.5 0.0 2.4e-42 145.7 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NMT1 PF09084.11 EDP43916.1 - 9.2e-51 172.8 0.0 1.2e-50 172.5 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_3 PF16868.5 EDP43916.1 - 0.01 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family PBP_like PF12727.7 EDP43916.1 - 0.05 12.7 0.0 0.077 12.1 0.0 1.3 1 0 0 1 1 1 0 PBP superfamily domain Thi4 PF01946.17 EDP43917.1 - 1.2e-95 319.2 0.0 1.5e-95 318.9 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EDP43917.1 - 2.2e-08 34.1 2.0 1.3e-07 31.5 1.6 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EDP43917.1 - 1.8e-07 31.3 0.2 4.9e-07 29.9 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EDP43917.1 - 3.1e-06 26.5 0.2 6e-06 25.6 0.2 1.3 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EDP43917.1 - 4.8e-06 25.9 1.1 3.6e-05 23.0 0.6 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EDP43917.1 - 5.4e-06 25.8 0.1 6.8e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP43917.1 - 1.9e-05 24.7 0.1 0.0003 20.8 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EDP43917.1 - 0.00033 19.5 0.4 0.00051 18.9 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EDP43917.1 - 0.00056 19.1 0.0 0.01 14.9 0.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EDP43917.1 - 0.013 14.7 0.2 0.031 13.5 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4387 PF14330.6 EDP43917.1 - 0.05 14.3 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) Trp_halogenase PF04820.14 EDP43917.1 - 0.14 11.0 0.1 0.2 10.5 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EDP43917.1 - 0.52 9.6 6.9 0.027 13.9 0.7 2.0 2 1 0 2 2 2 0 FAD dependent oxidoreductase ERCC4 PF02732.15 EDP43920.1 - 1.3e-19 71.0 0.0 6e-19 68.8 0.0 2.1 2 0 0 2 2 2 1 ERCC4 domain DUF3209 PF11483.8 EDP43920.1 - 0.1 13.1 0.5 0.35 11.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3209) Peptidase_M17 PF00883.21 EDP43921.1 - 4.7e-117 390.7 0.1 5.9e-117 390.4 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EDP43921.1 - 0.024 14.5 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain DAO PF01266.24 EDP43922.1 - 6.9e-56 190.3 0.3 7.8e-56 190.1 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP43922.1 - 4.2e-07 29.5 0.8 0.0071 15.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP43922.1 - 4.9e-07 30.2 1.1 0.019 15.5 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDP43922.1 - 0.0001 21.5 1.3 0.00088 18.5 1.3 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EDP43922.1 - 0.002 18.3 0.1 0.0046 17.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDP43922.1 - 0.0022 17.3 0.2 0.0037 16.5 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Mqo PF06039.15 EDP43922.1 - 0.045 12.3 0.1 3.4 6.1 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) HI0933_like PF03486.14 EDP43922.1 - 0.055 12.2 0.3 0.52 9.0 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein RRM_1 PF00076.22 EDP43923.1 - 1.6e-08 34.2 0.0 6.1e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSN1_7TM PF02714.15 EDP43924.1 - 7.6e-61 205.8 18.9 9.9e-61 205.4 18.9 1.1 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EDP43924.1 - 2.4e-08 34.4 0.0 4.4e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDP43924.1 - 0.056 13.6 0.6 0.11 12.6 0.6 1.4 1 0 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter tRNA_int_end_N2 PF12928.7 EDP43925.1 - 2.1e-18 66.3 0.0 3e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EDP43925.1 - 0.0034 17.0 0.0 0.0059 16.2 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Adap_comp_sub PF00928.21 EDP43926.1 - 4.2e-65 219.7 0.1 5.1e-65 219.5 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family muHD PF10291.9 EDP43926.1 - 1.4e-05 24.7 0.5 2.5e-05 23.8 0.5 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Clat_adaptor_s PF01217.20 EDP43926.1 - 0.00013 21.9 1.0 0.00027 20.9 1.0 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_47 PF01532.20 EDP43927.1 - 2.9e-94 316.5 0.0 3.7e-94 316.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 ArnB_C PF18677.1 EDP43927.1 - 0.11 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain Glyco_hydro_47 PF01532.20 EDP43928.1 - 6.8e-46 157.1 0.0 7.9e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CedA PF10729.9 EDP43928.1 - 0.0014 18.4 0.2 0.0027 17.5 0.0 1.5 2 0 0 2 2 2 1 Cell division activator CedA Glyco_transf_20 PF00982.21 EDP43929.1 - 2.8e-131 438.5 0.1 3.9e-131 438.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EDP43929.1 - 4.4e-70 235.4 0.0 6.9e-70 234.8 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase SH3_2 PF07653.17 EDP43929.1 - 0.04 13.6 0.0 2.8 7.7 0.0 2.9 3 0 0 3 3 3 0 Variant SH3 domain Dor1 PF04124.12 EDP43931.1 - 7.5e-09 34.7 8.2 1.5e-08 33.7 6.8 1.9 2 0 0 2 2 2 1 Dor1-like family SMC_hinge PF06470.13 EDP43932.1 - 1.1e-31 109.5 0.0 2.6e-31 108.4 0.0 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.19 EDP43932.1 - 2.5e-08 33.6 6.0 2.5e-08 33.6 6.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF1664 PF07889.12 EDP43932.1 - 1 9.4 44.8 0.13 12.3 2.9 7.7 6 2 2 8 8 8 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EDP43932.1 - 6.6 7.3 13.6 15 6.1 0.2 6.1 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF3533 PF12051.8 EDP43933.1 - 1.3e-87 294.2 12.0 1.6e-87 293.9 12.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Lipase_3 PF01764.25 EDP43934.1 - 2.5e-19 69.6 0.0 3.3e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EDP43934.1 - 0.044 13.3 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Sel1 PF08238.12 EDP43935.1 - 1.2e-33 114.8 28.1 2.4e-05 24.9 0.5 8.1 8 0 0 8 8 8 7 Sel1 repeat Exo_endo_phos PF03372.23 EDP43937.1 - 3.9e-24 85.4 0.0 1.8e-23 83.3 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EDP43937.1 - 3.8e-09 36.2 3.9 2.2e-05 24.1 1.5 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EDP43937.1 - 4.4e-08 33.3 4.3 0.00028 21.2 1.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) HSP90 PF00183.18 EDP43938.1 - 5.2e-228 758.1 29.2 6.2e-228 757.9 29.2 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EDP43938.1 - 1.2e-14 54.7 0.1 2.5e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDP43938.1 - 9.9e-11 41.6 0.1 3.2e-10 40.0 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 EDP43938.1 - 0.012 15.6 0.1 0.049 13.6 0.1 2.0 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN HBS1_N PF08938.10 EDP43938.1 - 0.036 14.4 1.1 0.036 14.4 1.1 2.5 2 0 0 2 2 2 0 HBS1 N-terminus Peptidase_C37 PF05416.12 EDP43938.1 - 0.71 8.3 10.5 0.26 9.7 0.5 2.2 2 0 0 2 2 2 0 Southampton virus-type processing peptidase Bystin PF05291.11 EDP43939.1 - 2.5e-132 440.6 0.0 3.4e-132 440.1 0.0 1.2 1 0 0 1 1 1 1 Bystin Adaptin_N PF01602.20 EDP43940.1 - 3.5e-80 270.1 0.1 5e-80 269.5 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDP43940.1 - 1.1e-13 51.5 0.0 1.4e-12 47.9 0.0 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDP43940.1 - 5.1e-06 26.8 3.2 0.0021 18.4 0.0 4.4 4 0 0 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 EDP43940.1 - 7.5e-05 23.1 8.5 1.9 9.1 0.2 6.2 6 1 1 7 7 7 2 HEAT-like repeat HEAT PF02985.22 EDP43940.1 - 0.00018 21.5 9.8 1.9 9.0 0.0 7.3 9 0 0 9 9 9 2 HEAT repeat DUF4357 PF14267.6 EDP43940.1 - 0.0051 16.7 0.1 0.6 10.1 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4357) Phos_pyr_kin PF08543.12 EDP43941.1 - 6.9e-37 127.1 0.0 1.6e-17 63.7 0.0 2.2 2 0 0 2 2 2 2 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EDP43941.1 - 3.6e-33 115.1 0.7 6.1e-33 114.4 0.7 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Thiolase_N PF00108.23 EDP43943.1 - 6.4e-77 258.4 0.1 8.8e-77 258.0 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDP43943.1 - 4.4e-47 158.8 0.3 1e-46 157.6 0.3 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDP43943.1 - 2e-05 24.3 0.4 4.5e-05 23.2 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAPS PF04499.15 EDP43944.1 - 2.3e-124 415.9 0.1 3.2e-124 415.4 0.1 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Malate_synthase PF01274.22 EDP43945.1 - 3.6e-206 685.5 0.0 4.1e-206 685.3 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 EDP43945.1 - 0.092 11.9 0.0 0.24 10.5 0.0 1.7 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Gar1 PF04410.14 EDP43946.1 - 7.8e-36 123.2 0.0 7.8e-36 123.2 0.0 2.0 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Ndc1_Nup PF09531.10 EDP43946.1 - 8.7 4.9 5.7 13 4.3 5.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Cyt-b5 PF00173.28 EDP43947.1 - 0.0082 16.3 0.0 4.9 7.4 0.0 2.2 1 1 1 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Inhibitor_I69 PF13734.6 EDP43947.1 - 0.18 12.3 0.1 0.39 11.2 0.1 1.7 1 1 0 1 1 1 0 Spi protease inhibitor FA_desaturase PF00487.24 EDP43948.1 - 5.1e-21 75.7 28.1 5.1e-21 75.7 28.1 1.5 2 0 0 2 2 2 1 Fatty acid desaturase DBR1 PF05011.13 EDP43949.1 - 2.9e-34 118.5 0.2 2.9e-34 118.5 0.2 1.5 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EDP43949.1 - 0.011 16.3 0.6 0.023 15.2 0.2 1.7 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase Peptidase_M16_M PF16187.5 EDP43950.1 - 1.8e-92 309.6 0.0 3.3e-92 308.7 0.0 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EDP43950.1 - 2e-41 141.5 0.1 2.4e-40 137.9 0.0 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EDP43950.1 - 8.6e-38 130.2 0.1 1.9e-22 80.2 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain DUF2267 PF10025.9 EDP43950.1 - 0.019 15.3 0.7 0.1 12.9 0.4 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) DUF3336 PF11815.8 EDP43950.1 - 0.022 14.5 1.9 0.81 9.4 0.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3336) DUF87 PF01935.17 EDP43950.1 - 0.11 12.5 2.3 1.7 8.7 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain Phage-tail_3 PF13550.6 EDP43950.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative phage tail protein Enolase_C PF00113.22 EDP43951.1 - 4.3e-116 387.3 0.5 5.1e-116 387.1 0.5 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 EDP43951.1 - 3.1e-09 36.7 0.0 3.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EDP43951.1 - 0.0034 16.6 0.2 0.0051 16.0 0.2 1.2 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Enolase_N PF03952.16 EDP43952.1 - 6.7e-58 194.5 0.0 7.7e-58 194.3 0.0 1.0 1 0 0 1 1 1 1 Enolase, N-terminal domain BLACT_WH PF17778.1 EDP43953.1 - 0.0069 16.3 0.1 0.018 15.0 0.1 1.7 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 EDP43953.1 - 0.0075 16.3 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Rrn6 PF10214.9 EDP43954.1 - 1.5e-08 33.7 2.5 1.6e-08 33.6 2.5 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor PNRC PF15365.6 EDP43955.1 - 1.5e-06 27.8 2.2 1.5e-06 27.8 2.2 3.3 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator motif XRN1_DBM PF18245.1 EDP43955.1 - 0.37 10.8 3.9 5.2 7.2 0.5 2.8 2 0 0 2 2 2 0 5-3 exonuclease XRN1 DCP1-binding motif DUF3519 PF12033.8 EDP43955.1 - 4.5 7.7 8.8 7.1 7.1 0.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3519) DUF1325 PF07039.11 EDP43956.1 - 3.1e-26 92.0 0.0 5.3e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain PCRF PF03462.18 EDP43957.1 - 2.2e-38 132.1 10.1 8.2e-38 130.2 6.3 2.8 2 1 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EDP43957.1 - 5.9e-35 119.7 3.1 5.9e-35 119.7 3.1 2.9 2 1 0 2 2 2 1 RF-1 domain Adaptin_N PF01602.20 EDP43958.1 - 1.6e-88 297.6 9.7 2.9e-88 296.7 9.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EDP43958.1 - 2e-58 195.9 0.0 6.3e-58 194.3 0.0 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EDP43958.1 - 1.2e-55 187.2 0.2 3.2e-55 185.9 0.2 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 EDP43958.1 - 1.8e-09 37.8 4.2 0.0089 16.4 0.0 4.4 2 1 4 6 6 6 4 HEAT repeats Cnd1 PF12717.7 EDP43958.1 - 2.5e-08 34.1 6.6 5e-07 29.9 0.5 3.3 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 EDP43958.1 - 0.00026 21.2 2.2 0.025 14.7 0.0 3.2 3 0 0 3 3 3 1 Parkin co-regulated protein HEAT PF02985.22 EDP43958.1 - 0.00034 20.6 0.2 0.23 11.8 0.0 4.4 5 0 0 5 5 5 1 HEAT repeat Coatomer_g_Cpla PF16381.5 EDP43958.1 - 0.00068 19.8 0.1 0.02 15.0 0.0 2.5 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform RNA_pol_Rpb1_5 PF04998.17 EDP43958.1 - 0.018 14.5 0.2 0.04 13.4 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Met_10 PF02475.16 EDP43958.1 - 0.031 14.0 1.3 0.052 13.3 0.4 1.9 2 0 0 2 2 2 0 Met-10+ like-protein DUF5578 PF17741.1 EDP43958.1 - 0.074 12.5 5.5 0.047 13.1 0.5 3.1 4 1 0 4 4 4 0 Family of unknown function (DUF5578) PaaB PF06243.11 EDP43958.1 - 0.079 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Phenylacetic acid degradation B SPX PF03105.19 EDP43959.1 - 1.5e-26 94.3 0.1 1.5e-26 94.3 0.1 1.4 2 0 0 2 2 2 1 SPX domain zf-C3HC4_3 PF13920.6 EDP43959.1 - 2e-05 24.3 10.2 3.4e-05 23.6 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP43959.1 - 5.3e-05 23.0 12.8 9.7e-05 22.2 12.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP43959.1 - 0.00018 21.6 12.0 0.00036 20.6 12.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EDP43959.1 - 0.00028 20.7 11.1 0.00051 19.8 11.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDP43959.1 - 0.00061 20.1 12.9 0.0012 19.2 12.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDP43959.1 - 0.001 19.0 11.5 0.0023 17.8 11.6 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 EDP43959.1 - 0.0051 16.7 7.2 0.01 15.7 7.2 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 EDP43959.1 - 0.011 15.7 10.0 0.026 14.5 10.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDP43959.1 - 0.013 15.3 13.0 0.023 14.6 13.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EDP43959.1 - 0.41 10.5 9.7 0.79 9.6 9.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain ABC_tran PF00005.27 EDP43961.1 - 6.9e-35 120.6 0.1 1.1e-16 61.6 0.0 3.0 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 EDP43961.1 - 8.1e-14 51.2 4.2 2.2e-13 49.8 4.2 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EDP43961.1 - 1.3e-10 41.1 4.4 0.00013 21.5 0.4 3.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDP43961.1 - 1.4e-08 35.0 4.3 0.2 11.5 0.8 4.2 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 EDP43961.1 - 1.3e-07 31.1 3.2 1.3e-07 31.1 3.2 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_6 PF12837.7 EDP43961.1 - 7e-06 25.9 11.4 4.6e-05 23.3 2.4 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_15 PF13175.6 EDP43961.1 - 7.2e-06 25.9 2.8 0.11 12.2 0.6 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 EDP43961.1 - 8e-06 26.3 0.1 0.026 15.0 0.2 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EDP43961.1 - 2e-05 24.6 0.1 0.088 12.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Fer4_10 PF13237.6 EDP43961.1 - 2.7e-05 24.2 8.6 0.0012 18.9 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_22 PF13401.6 EDP43961.1 - 4.9e-05 23.6 0.0 0.018 15.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDP43961.1 - 0.00011 22.6 0.0 0.046 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Fer4_7 PF12838.7 EDP43961.1 - 0.00013 22.4 6.8 0.00041 20.9 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain NACHT PF05729.12 EDP43961.1 - 0.00016 21.6 1.5 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EDP43961.1 - 0.0008 19.8 0.3 0.22 11.9 0.0 2.9 3 0 0 3 3 2 1 RNA helicase AAA_29 PF13555.6 EDP43961.1 - 0.00098 18.8 1.9 1.2 8.9 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 EDP43961.1 - 0.0013 18.7 0.0 0.85 9.5 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Fer4_21 PF14697.6 EDP43961.1 - 0.0016 18.5 12.3 0.0032 17.5 12.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_24 PF13479.6 EDP43961.1 - 0.0019 18.0 0.9 0.35 10.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDP43961.1 - 0.0021 17.6 1.8 0.0096 15.5 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 EDP43961.1 - 0.0023 18.1 0.8 0.43 10.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EDP43961.1 - 0.0024 17.1 0.0 0.12 11.5 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain Fer4_2 PF12797.7 EDP43961.1 - 0.0025 17.8 0.9 0.0025 17.8 0.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_9 PF13187.6 EDP43961.1 - 0.0033 17.6 10.6 0.008 16.3 10.6 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain AAA_28 PF13521.6 EDP43961.1 - 0.0063 16.8 0.7 1.7 8.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EDP43961.1 - 0.0065 16.5 0.2 0.12 12.4 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_16 PF13484.6 EDP43961.1 - 0.0081 17.1 0.3 0.0081 17.1 0.3 3.0 2 1 0 2 2 1 1 4Fe-4S double cluster binding domain SRP54 PF00448.22 EDP43961.1 - 0.013 15.2 3.5 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 EDP43961.1 - 0.015 15.5 0.0 8 6.8 0.0 3.1 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Fer4_17 PF13534.6 EDP43961.1 - 0.021 15.3 0.1 0.021 15.3 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_18 PF13238.6 EDP43961.1 - 0.023 15.2 0.1 8.3 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 EDP43961.1 - 0.025 14.3 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_14 PF13173.6 EDP43961.1 - 0.046 13.7 1.1 12 5.9 0.1 3.3 2 2 1 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EDP43961.1 - 0.054 13.6 0.9 8 6.6 0.1 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EDP43961.1 - 0.066 12.9 0.4 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDP43961.1 - 0.081 13.4 0.5 0.081 13.4 0.5 2.6 2 1 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 EDP43961.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain TniB PF05621.11 EDP43961.1 - 0.13 11.7 0.0 3.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.14 EDP43961.1 - 0.3 11.1 2.0 3.5 7.6 0.0 3.1 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EDP43961.1 - 0.31 11.3 0.7 2.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Fer4_4 PF12800.7 EDP43961.1 - 0.53 10.9 14.4 0.28 11.8 2.9 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain SNF2_N PF00176.23 EDP43962.1 - 2.9e-44 151.2 0.0 2.7e-35 121.7 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP43962.1 - 3.3e-11 43.5 0.0 7.3e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain KH_8 PF17903.1 EDP43963.1 - 1.6e-32 111.4 0.1 3.9e-32 110.2 0.0 1.7 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 EDP43963.1 - 0.00034 20.4 0.1 0.00066 19.5 0.1 1.5 1 0 0 1 1 1 1 KH domain FHA PF00498.26 EDP43964.1 - 6.9e-18 64.8 0.0 1.3e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EDP43964.1 - 4.3e-12 45.6 9.5 7.5e-12 44.8 9.5 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EDP43964.1 - 1.6e-08 34.7 10.9 2.7e-08 34.0 10.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP43964.1 - 0.00016 21.4 12.1 0.00028 20.7 12.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Yop-YscD_cpl PF16697.5 EDP43964.1 - 0.00025 21.3 0.0 0.00071 19.8 0.0 1.7 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 EDP43964.1 - 0.00095 19.0 10.6 0.0017 18.2 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP43964.1 - 0.0012 18.8 8.6 0.002 18.1 8.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EDP43964.1 - 0.0086 16.3 7.9 0.023 15.0 7.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Sec_GG PF07549.14 EDP43964.1 - 0.01 15.3 0.3 0.025 14.1 0.3 1.7 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-ANAPC11 PF12861.7 EDP43964.1 - 0.081 13.0 4.3 0.14 12.2 4.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 EDP43964.1 - 0.23 11.4 4.6 0.52 10.3 4.6 1.6 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EDP43964.1 - 0.27 11.1 9.4 0.53 10.2 9.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EDP43964.1 - 0.3 10.7 6.0 0.55 9.9 6.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EDP43964.1 - 3 8.1 7.5 8.4 6.6 7.5 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDP43964.1 - 8.7 6.5 11.5 23 5.1 11.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger DEAD PF00270.29 EDP43965.1 - 3.4e-48 163.7 0.1 1.7e-47 161.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43965.1 - 1.2e-30 106.1 0.1 4.1e-29 101.2 0.0 2.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EDP43965.1 - 0.053 13.8 0.8 0.26 11.6 0.2 2.6 2 1 0 2 2 2 0 AAA domain IF-2B PF01008.17 EDP43966.1 - 1.9e-57 194.7 0.0 2.2e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Pkinase PF00069.25 EDP43967.1 - 8e-54 182.8 0.0 9.8e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP43967.1 - 6.1e-25 88.0 0.1 7.1e-25 87.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP43967.1 - 0.00056 19.3 0.1 0.00098 18.5 0.1 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDP43967.1 - 0.0042 16.1 0.2 0.005 15.8 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDP43967.1 - 0.039 13.3 0.2 0.075 12.4 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP43967.1 - 0.05 13.5 0.1 0.11 12.5 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Got1 PF04178.12 EDP43968.1 - 3e-18 66.3 13.0 4.1e-18 65.8 13.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family CD20 PF04103.15 EDP43968.1 - 0.22 11.6 6.8 0.36 10.9 6.8 1.3 1 1 0 1 1 1 0 CD20-like family Lipase_GDSL PF00657.22 EDP43969.1 - 1.9e-09 37.8 0.8 7.3e-09 35.9 0.8 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EDP43969.1 - 2.4e-09 37.8 1.5 4.7e-09 36.9 1.5 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Sec23_trunk PF04811.15 EDP43970.1 - 3.2e-64 216.8 0.0 5.1e-64 216.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EDP43970.1 - 3e-22 78.4 0.1 6.7e-22 77.3 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EDP43970.1 - 2.2e-15 56.4 6.0 3.6e-15 55.7 6.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EDP43970.1 - 7.8e-15 55.4 0.0 1.5e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EDP43970.1 - 9.8e-05 22.2 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EDP43970.1 - 0.0045 16.4 0.8 0.0099 15.3 0.8 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain dbPDZ_assoc PF16610.5 EDP43970.1 - 0.26 11.5 4.4 0.53 10.5 3.3 2.1 1 1 1 2 2 2 0 Unstructured region between two PDZ domains on Dlg5 Collagen PF01391.18 EDP43970.1 - 0.87 9.4 2.2 1.7 8.5 2.2 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Sporozoite_P67 PF05642.11 EDP43970.1 - 8.6 4.3 9.5 12 3.8 9.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRM_1 PF00076.22 EDP43971.1 - 1e-06 28.4 0.0 2.1e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IGR PF09597.10 EDP43971.1 - 0.086 13.0 0.5 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 IGR protein motif FmiP_Thoc5 PF09766.9 EDP43972.1 - 1e-08 34.9 14.9 1.4e-08 34.5 14.9 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Trimer_CC PF08954.11 EDP43972.1 - 0.17 11.4 6.3 1.1 8.8 1.9 2.8 1 1 1 2 2 2 0 Trimerisation motif AAA_23 PF13476.6 EDP43972.1 - 0.3 11.5 1.7 0.32 11.5 1.7 1.1 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EDP43972.1 - 0.34 11.2 9.6 0.26 11.6 1.3 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 EDP43972.1 - 0.46 10.7 4.2 0.48 10.6 1.8 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NYD-SP28_assoc PF14775.6 EDP43972.1 - 3.4 7.8 8.0 1.2 9.3 1.9 2.4 2 0 0 2 2 2 0 Sperm tail C-terminal domain Peptidase_C50 PF03568.17 EDP43973.1 - 2.2e-108 362.9 0.0 3.3e-108 362.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C50 TPR_10 PF13374.6 EDP43973.1 - 0.47 10.4 4.3 23 5.0 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat SPA PF08616.10 EDP43974.1 - 4.2e-31 107.3 0.0 8.7e-31 106.2 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 EDP43974.1 - 3.4e-12 47.0 0.0 6.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking GCFC PF07842.12 EDP43976.1 - 3.1e-68 230.4 8.6 4.5e-68 229.9 8.6 1.2 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EDP43976.1 - 3.8e-11 42.7 1.2 3.8e-11 42.7 1.2 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EDP43976.1 - 1.1e-06 28.7 0.3 5.9e-05 23.1 0.2 2.8 2 0 0 2 2 2 1 G-patch domain ApoLp-III PF07464.11 EDP43976.1 - 0.044 13.9 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) ASFV_J13L PF05568.11 EDP43976.1 - 0.084 12.6 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF2205 PF10224.9 EDP43976.1 - 0.18 11.9 0.3 0.38 10.8 0.3 1.6 1 0 0 1 1 1 0 Short coiled-coil protein TFIIA PF03153.13 EDP43976.1 - 0.18 11.7 4.3 0.34 10.8 4.3 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM176 PF14851.6 EDP43976.1 - 1.6 8.4 3.8 5.1 6.7 3.8 1.8 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 EDP43976.1 - 1.9 8.5 4.9 4 7.4 4.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2076 PF09849.9 EDP43976.1 - 2.8 7.9 11.1 0.85 9.6 7.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) NOA36 PF06524.12 EDP43976.1 - 5.1 6.3 11.7 10 5.3 11.7 1.4 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.13 EDP43976.1 - 9.9 6.0 7.2 36 4.1 4.4 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Cyclin_N PF00134.23 EDP43977.1 - 5.5e-10 39.1 0.0 1.1e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 EDP43977.1 - 0.0072 16.4 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Cyclin_C PF02984.19 EDP43977.1 - 0.16 12.1 4.6 0.84 9.7 0.1 2.9 2 1 1 3 3 3 0 Cyclin, C-terminal domain TPP_enzyme_N PF02776.18 EDP43978.1 - 2.5e-51 173.7 0.1 1e-50 171.7 0.1 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EDP43978.1 - 2.3e-48 163.8 0.1 2.2e-46 157.4 0.0 2.9 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDP43978.1 - 7.2e-41 139.1 1.1 1.5e-40 138.1 0.3 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Glyco_trans_4_4 PF13579.6 EDP43978.1 - 0.11 12.9 2.4 0.33 11.4 0.6 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain POR_N PF01855.19 EDP43978.1 - 0.12 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg CUE PF02845.16 EDP43979.1 - 0.026 14.2 0.0 0.069 12.9 0.0 1.7 2 0 0 2 2 2 0 CUE domain Ank_4 PF13637.6 EDP43981.1 - 4.4e-09 36.7 1.2 4.5e-05 23.9 0.1 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EDP43981.1 - 6.8e-09 36.2 0.4 1e-08 35.7 0.4 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP43981.1 - 5.2e-08 32.6 0.8 0.096 13.3 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EDP43981.1 - 2.4e-06 27.7 0.8 0.09 13.3 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EDP43981.1 - 0.00031 21.0 2.1 0.0021 18.3 0.7 2.7 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Nrap_D4 PF17405.2 EDP43982.1 - 1.4e-57 194.5 0.0 2.5e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EDP43982.1 - 1.1e-44 152.1 0.2 2.4e-44 150.9 0.2 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EDP43982.1 - 2.8e-44 150.6 0.0 8.3e-43 145.8 0.0 2.5 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 EDP43982.1 - 2.1e-40 138.2 0.0 3.3e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 EDP43982.1 - 3.1e-37 128.1 0.0 5.9e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EDP43982.1 - 1.3e-34 119.3 0.0 2.2e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 6 PI31_Prot_C PF08577.11 EDP43983.1 - 3.1e-10 41.1 16.0 3.1e-10 41.1 16.0 1.9 1 1 1 2 2 2 1 PI31 proteasome regulator PI31_Prot_N PF11566.8 EDP43983.1 - 0.001 18.9 0.2 0.05 13.4 0.2 2.1 1 1 0 1 1 1 1 PI31 proteasome regulator N-terminal VEGFR-2_TMD PF17988.1 EDP43984.1 - 0.49 9.9 0.2 0.49 9.9 0.2 2.4 2 0 0 2 2 2 0 VEGFR-2 Transmembrane domain GPP34 PF05719.11 EDP43985.1 - 1.1e-55 188.9 0.4 1.3e-55 188.6 0.4 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Stevor PF17410.2 EDP43986.1 - 0.004 16.7 0.0 0.0064 16.1 0.0 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame VASt PF16016.5 EDP43987.1 - 2.6e-39 135.1 0.1 4.3e-39 134.4 0.1 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EDP43987.1 - 1.5e-23 82.8 0.0 3.2e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DEAD PF00270.29 EDP43988.1 - 1.6e-41 142.0 0.0 3e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP43988.1 - 1.1e-19 70.8 0.0 3.7e-19 69.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDP43988.1 - 2.2e-16 59.8 0.0 6.1e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDP43988.1 - 1.6e-06 28.2 0.0 4.3e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EDP43988.1 - 0.16 11.3 6.3 0.42 9.9 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4551 PF15087.6 EDP43988.1 - 0.62 8.8 5.4 0.96 8.2 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Pribosyl_synth PF14572.6 EDP43989.1 - 1.6e-33 116.3 3.0 8.8e-29 100.8 1.0 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EDP43989.1 - 1.5e-19 70.0 3.4 3.9e-19 68.7 0.3 2.7 3 1 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EDP43989.1 - 7.7e-15 54.8 0.3 2.6e-14 53.0 0.3 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDP43989.1 - 0.0065 15.9 0.3 0.011 15.2 0.3 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EDP43989.1 - 0.085 12.4 1.1 0.13 11.7 0.1 1.9 2 0 0 2 2 2 0 Phosphoribosyl transferase PduV-EutP PF10662.9 EDP43989.1 - 0.42 10.3 3.1 17 5.1 0.0 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation PWI PF01480.17 EDP43990.1 - 2.7e-28 98.1 0.1 4.1e-28 97.5 0.1 1.3 1 0 0 1 1 1 1 PWI domain RecA_dep_nuc PF16786.5 EDP43990.1 - 0.024 14.8 0.0 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Recombination enhancement, RecA-dependent nuclease WD40 PF00400.32 EDP43991.1 - 3.3e-60 198.6 13.7 1.5e-08 35.1 0.0 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP43991.1 - 3.7e-21 75.2 0.0 7.1e-05 23.0 0.0 6.6 1 1 6 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EDP43991.1 - 8.4e-10 38.5 0.0 0.028 13.8 0.0 4.4 4 0 0 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 EDP43991.1 - 2.8e-08 33.1 0.1 0.76 8.7 0.0 5.2 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Tup_N PF08581.10 EDP43991.1 - 2.3e-06 27.8 0.6 4e-06 27.0 0.6 1.4 1 0 0 1 1 1 1 Tup N-terminal PD40 PF07676.12 EDP43991.1 - 7.2e-06 25.8 0.1 12 6.0 0.0 4.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EDP43991.1 - 0.00097 18.5 0.1 0.93 8.8 0.0 3.4 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 EDP43991.1 - 0.017 14.8 2.3 65 3.3 0.0 4.8 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 EDP43991.1 - 0.039 12.5 0.0 0.55 8.7 0.0 2.6 2 1 0 2 2 2 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 EDP43991.1 - 0.047 12.4 0.7 0.92 8.2 0.4 2.5 1 1 0 2 2 2 0 Nup133 N terminal like PX PF00787.24 EDP43992.1 - 4.9e-14 52.3 0.0 8.1e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 PX domain SNARE PF05739.19 EDP43992.1 - 0.018 15.0 0.4 0.045 13.8 0.4 1.7 1 0 0 1 1 1 0 SNARE domain Myb_CC_LHEQLE PF14379.6 EDP43992.1 - 8.1 6.2 8.2 2.5 7.9 0.1 3.4 4 0 0 4 4 4 0 MYB-CC type transfactor, LHEQLE motif INCENP_ARK-bind PF03941.15 EDP43993.1 - 4.8e-11 42.4 0.0 1.2e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Galactosyl_T PF01762.21 EDP43994.1 - 9.7e-10 38.6 0.6 2.9e-06 27.2 0.0 3.2 2 1 1 3 3 3 3 Galactosyltransferase Cas9_b_hairpin PF17893.1 EDP43995.1 - 0.074 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain DUF499 PF04465.12 EDP43995.1 - 0.14 9.8 0.1 0.19 9.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF499) PhoLip_ATPase_N PF16209.5 EDP43997.1 - 4.7e-23 80.7 2.2 8.7e-23 79.8 2.2 1.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EDP43997.1 - 2.5e-05 23.9 1.4 3.9e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase DUF5629 PF18629.1 EDP43997.1 - 0.07 13.7 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5629) PhoLip_ATPase_C PF16212.5 EDP43998.1 - 1e-68 231.8 27.4 1.3e-68 231.4 27.4 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EDP43998.1 - 1.6e-08 35.1 0.0 0.001 19.4 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EDP43998.1 - 0.00018 21.3 0.8 0.0035 17.1 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Acyl-CoA_dh_1 PF00441.24 EDP43999.1 - 8e-46 156.0 4.0 8e-46 156.0 4.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EDP43999.1 - 2.1e-25 89.6 0.0 6.4e-25 88.0 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EDP43999.1 - 2e-23 82.4 0.1 3.5e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EDP43999.1 - 1.1e-21 77.6 1.4 1.1e-21 77.6 1.4 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain AgrD PF05931.11 EDP43999.1 - 0.015 15.4 0.4 0.092 12.8 0.0 2.2 2 0 0 2 2 2 0 Staphylococcal AgrD protein Tfb2 PF03849.14 EDP44000.1 - 6.3e-85 285.3 2.5 7e-85 285.1 2.5 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.6 EDP44000.1 - 0.00023 21.3 0.0 0.00036 20.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cnd3 PF12719.7 EDP44000.1 - 0.068 12.4 0.7 0.26 10.5 0.2 1.9 1 1 1 2 2 2 0 Nuclear condensing complex subunits, C-term domain SNF2_N PF00176.23 EDP44001.1 - 6.1e-54 183.0 0.0 8.9e-54 182.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EDP44001.1 - 7.5e-41 140.3 0.1 1.5e-40 139.3 0.1 1.4 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.31 EDP44001.1 - 6.4e-15 55.5 0.0 1.7e-14 54.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP44001.1 - 5.1e-07 29.9 0.0 1.3e-06 28.5 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EDP44001.1 - 0.045 12.9 0.0 0.14 11.3 0.0 1.8 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Glyco_hydro_16 PF00722.21 EDP44002.1 - 0.00098 18.6 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 RNase_PH PF01138.21 EDP44003.1 - 1.1e-28 100.3 0.0 1.6e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Methyltransf_15 PF09445.10 EDP44004.1 - 3e-10 39.9 0.1 3.8e-10 39.6 0.1 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EDP44004.1 - 0.0002 22.0 0.0 0.00029 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP44004.1 - 0.00065 19.5 0.1 0.0011 18.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 EDP44004.1 - 0.0042 16.8 0.0 0.0045 16.7 0.0 1.1 1 0 0 1 1 1 1 DNA methylase GAD-like PF08887.11 EDP44004.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.4 1 1 0 1 1 1 0 GAD-like domain Methyltransf_11 PF08241.12 EDP44004.1 - 0.022 15.4 0.0 0.034 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EDP44004.1 - 0.07 12.9 0.1 0.12 12.1 0.0 1.4 2 0 0 2 2 2 0 Met-10+ like-protein PrmA PF06325.13 EDP44004.1 - 0.12 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EDP44005.1 - 4.1e-10 39.5 0.1 5e-09 35.9 0.1 1.9 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UQ_con PF00179.26 EDP44006.1 - 7.7e-42 142.3 0.1 8.6e-42 142.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDP44006.1 - 0.00058 19.6 0.0 0.00077 19.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EDP44006.1 - 0.095 13.0 0.0 0.15 12.4 0.0 1.4 1 1 0 1 1 1 0 RWD domain Aminotran_1_2 PF00155.21 EDP44007.1 - 3.9e-37 128.3 0.0 4.7e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EDP44007.1 - 0.00032 19.4 0.0 0.00053 18.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Strep_his_triad PF04270.13 EDP44007.1 - 0.0084 16.1 0.0 5.9 7.0 0.0 2.7 2 0 0 2 2 2 2 Streptococcal histidine triad protein Beta_elim_lyase PF01212.21 EDP44007.1 - 0.094 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase WD40 PF00400.32 EDP44008.1 - 2e-38 129.7 19.3 1.1e-09 38.7 0.3 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44008.1 - 3.1e-10 40.2 0.0 0.014 15.6 0.0 4.4 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP44008.1 - 0.00025 19.8 0.1 4.7 5.7 0.0 3.7 4 0 0 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EDP44008.1 - 0.00053 19.1 0.0 0.28 10.1 0.0 3.8 3 1 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Aldo_ket_red PF00248.21 EDP44009.1 - 1.1e-52 179.1 0.0 1.1e-50 172.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family TPR_1 PF00515.28 EDP44010.1 - 2.5e-05 23.9 0.3 0.019 14.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44010.1 - 7.8e-05 22.5 0.1 7.8e-05 22.5 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44010.1 - 0.00012 22.1 0.8 0.0071 16.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44010.1 - 0.0012 19.0 0.0 0.6 10.6 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44010.1 - 0.015 15.5 1.5 0.073 13.3 0.5 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EDP44010.1 - 0.064 13.9 7.8 0.097 13.3 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Paf67 PF10255.9 EDP44010.1 - 0.16 10.9 0.0 0.31 10.0 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 TPR_19 PF14559.6 EDP44010.1 - 0.2 12.2 1.4 23 5.6 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44010.1 - 0.91 9.9 13.4 6.6 7.1 0.8 5.1 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44010.1 - 1 10.4 14.9 4.5 8.4 1.0 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44010.1 - 1.2 9.3 3.3 80 3.6 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat F-box-like PF12937.7 EDP44011.1 - 7.2e-11 41.8 2.9 7.2e-11 41.8 2.9 3.2 3 1 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EDP44011.1 - 2.5e-10 40.4 2.9 1 9.9 0.0 6.2 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDP44011.1 - 4e-10 38.9 8.2 0.019 15.0 0.0 8.0 8 0 0 8 8 8 2 Leucine Rich repeat F-box PF00646.33 EDP44011.1 - 0.00042 20.1 6.0 0.0014 18.5 0.5 4.2 4 0 0 4 4 4 1 F-box domain LRR_1 PF00560.33 EDP44011.1 - 0.021 15.3 3.8 1.9e+02 3.3 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich Repeat Preseq_ALAS PF09029.10 EDP44011.1 - 0.025 15.0 0.2 0.094 13.2 0.2 2.0 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence RNase_P_Rpp14 PF01900.19 EDP44011.1 - 0.045 14.0 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 Rpp14/Pop5 family Coatomer_WDAD PF04053.14 EDP44012.1 - 1.5e-136 456.0 0.0 4e-136 454.6 0.0 1.7 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EDP44012.1 - 1.5e-41 139.6 12.1 4.2e-07 30.5 0.0 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44012.1 - 3.5e-07 30.4 0.2 0.0087 16.3 0.0 5.3 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP44012.1 - 0.0031 16.2 0.8 0.081 11.6 0.1 3.0 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Myb_DNA-binding PF00249.31 EDP44013.1 - 2.4e-12 46.8 1.0 4.4e-12 46.0 1.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP44013.1 - 2.3e-07 30.9 0.1 4.8e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Sec2p PF06428.11 EDP44013.1 - 0.12 12.4 0.2 0.26 11.3 0.2 1.6 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Lzipper-MIP1 PF14389.6 EDP44013.1 - 0.21 11.9 12.5 1.6 9.1 1.6 3.9 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 APC_N_CC PF16689.5 EDP44013.1 - 0.22 11.6 1.4 0.33 11.0 0.2 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain CCDC-167 PF15188.6 EDP44013.1 - 0.33 11.3 1.3 5.7 7.4 0.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Mod_r PF07200.13 EDP44014.1 - 6.5e-07 29.6 0.2 8.4e-07 29.2 0.2 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF202 PF02656.15 EDP44015.1 - 8.8e-14 51.7 6.9 8.8e-14 51.7 6.9 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Pro_isomerase PF00160.21 EDP44016.1 - 4.4e-44 150.5 0.0 5.1e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RTP1_C1 PF10363.9 EDP44017.1 - 2.1e-31 108.4 0.1 7.7e-31 106.6 0.0 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 EDP44017.1 - 0.0084 16.0 0.0 0.026 14.4 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) STIMATE PF12400.8 EDP44018.1 - 1.7e-12 48.0 4.0 1.9e-12 47.8 4.0 1.1 1 0 0 1 1 1 1 STIMATE family GDPD PF03009.17 EDP44019.1 - 2.6e-13 50.3 0.0 3.3e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EDP44019.1 - 3.8e-05 24.0 1.4 7.1e-05 23.1 1.4 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Palm_thioest PF02089.15 EDP44020.1 - 5.9e-77 258.8 0.0 7.1e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EDP44020.1 - 5.5e-05 22.9 0.0 8.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold MBOAT PF03062.19 EDP44021.1 - 4.6e-42 144.6 13.3 7e-42 144.0 13.3 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Vps5 PF09325.10 EDP44022.1 - 1.1e-16 61.1 7.6 2e-16 60.3 7.6 1.5 1 0 0 1 1 1 1 Vps5 C terminal like Trypan_PARP PF05887.11 EDP44022.1 - 0.066 13.2 5.4 0.13 12.3 5.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) WD40 PF00400.32 EDP44023.1 - 2.2e-19 69.4 5.4 9.4e-05 23.1 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44023.1 - 7.6e-05 22.9 0.0 1.8 8.9 0.0 3.8 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain GTP_EFTU PF00009.27 EDP44024.1 - 1.8e-41 141.8 0.0 2.8e-41 141.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EDP44024.1 - 2.5e-07 30.7 0.0 6.1e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EDP44024.1 - 1.9e-05 25.0 0.0 4.5e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EDP44024.1 - 0.036 13.7 0.2 0.075 12.6 0.0 1.6 2 0 0 2 2 2 0 Ras family MMR_HSR1 PF01926.23 EDP44024.1 - 0.082 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase EFG_C PF00679.24 EDP44025.1 - 7.8e-14 51.5 0.0 1.6e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EDP44025.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV ADH_zinc_N_2 PF13602.6 EDP44027.1 - 4.8e-09 37.4 0.0 9.1e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP44027.1 - 6.6e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDP44027.1 - 0.0012 18.8 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LRR_4 PF12799.7 EDP44028.1 - 7.5e-09 35.7 2.0 0.0078 16.6 0.3 4.1 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP44028.1 - 8.6e-09 35.0 9.7 1.4e-05 24.8 0.2 4.0 2 1 3 5 5 5 3 Leucine rich repeat LRR_9 PF14580.6 EDP44028.1 - 1.4e-06 27.9 0.1 0.0031 17.1 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EDP44028.1 - 0.0041 17.1 2.1 1.4 9.1 0.0 4.4 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.33 EDP44028.1 - 0.079 13.5 2.5 1.2e+02 3.9 0.1 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat RRM_1 PF00076.22 EDP44030.1 - 6.9e-21 73.9 0.0 2.8e-15 55.9 0.0 4.0 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP44030.1 - 0.0011 18.9 0.0 0.003 17.5 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EDP44030.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_3 PF08777.11 EDP44030.1 - 0.028 14.4 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif MAP65_ASE1 PF03999.12 EDP44030.1 - 0.088 11.5 7.2 0.12 11.0 7.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) X PF00739.19 EDP44030.1 - 0.21 11.7 5.3 0.44 10.7 5.3 1.5 1 0 0 1 1 1 0 Trans-activation protein X QWRF PF04484.12 EDP44030.1 - 0.41 10.4 19.9 0.23 11.2 17.2 1.7 2 0 0 2 2 2 0 QWRF family Ribosomal_L7Ae PF01248.26 EDP44031.1 - 4e-29 100.2 0.9 4.8e-29 99.9 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDP44031.1 - 0.067 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain Ribosomal_S17_N PF16205.5 EDP44032.1 - 2.6e-28 98.2 0.1 6.1e-28 97.0 0.0 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EDP44032.1 - 1.3e-24 86.1 1.0 2.4e-24 85.2 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF922 PF06037.11 EDP44032.1 - 0.044 13.6 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Ribosomal_L1 PF00687.21 EDP44033.1 - 2.7e-47 161.2 2.3 3.3e-47 160.9 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DNA_pol_lambd_f PF10391.9 EDP44033.1 - 0.05 13.4 0.1 9.6 6.1 0.0 2.7 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Isy1 PF06246.12 EDP44034.1 - 1.9e-84 283.2 0.6 2.2e-84 283.0 0.6 1.0 1 0 0 1 1 1 1 Isy1-like splicing family CTP_transf_like PF01467.26 EDP44035.1 - 0.006 16.8 0.0 0.012 15.9 0.0 1.6 1 1 0 1 1 1 1 Cytidylyltransferase-like TCTP PF00838.17 EDP44036.1 - 1.6e-65 220.5 0.6 1.8e-65 220.3 0.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein IKBKB_SDD PF18397.1 EDP44036.1 - 0.026 13.8 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 IQBAL scaffold dimerization domain Mus7 PF09462.10 EDP44036.1 - 0.036 12.9 0.0 0.041 12.7 0.0 1.0 1 0 0 1 1 1 0 Mus7/MMS22 family RcbX PF02341.15 EDP44036.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 RbcX protein Nse4-Nse3_bdg PF15412.6 EDP44036.1 - 0.13 12.3 0.5 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Binding domain of Nse4/EID3 to Nse3-MAGE RRM_1 PF00076.22 EDP44037.1 - 4.2e-18 64.9 0.0 6.7e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP44037.1 - 0.072 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif CTNNBL PF08216.11 EDP44038.1 - 3.5e-30 104.2 0.8 7.5e-30 103.2 0.8 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 EDP44038.1 - 0.0031 17.5 0.9 1.5 9.0 0.0 3.8 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF3445 PF11927.8 EDP44038.1 - 0.015 14.9 0.3 0.029 14.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) Vac14_Fab1_bd PF12755.7 EDP44039.1 - 2.6e-44 149.7 0.0 2.3e-37 127.5 0.0 4.3 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EDP44039.1 - 1.7e-13 49.6 3.9 0.0006 19.9 0.0 6.5 6 0 0 6 6 6 2 HEAT repeat MMS19_C PF12460.8 EDP44039.1 - 2.5e-08 33.5 0.5 0.00054 19.2 0.0 2.5 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 EDP44039.1 - 2.4e-07 31.1 2.0 0.03 14.7 0.0 5.0 4 2 1 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EDP44039.1 - 4.3e-05 23.9 1.2 5.6 7.6 0.0 4.4 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 EDP44039.1 - 0.00013 22.0 0.4 14 5.7 0.0 4.0 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Xpo1 PF08389.12 EDP44039.1 - 0.0055 16.8 0.2 6.3 6.9 0.0 2.8 3 0 0 3 3 3 2 Exportin 1-like protein CLASP_N PF12348.8 EDP44039.1 - 0.017 14.7 0.0 4.6 6.7 0.0 3.7 4 0 0 4 4 4 0 CLASP N terminal Tti2 PF10521.9 EDP44039.1 - 0.047 13.2 0.1 1.4 8.4 0.0 3.1 4 1 0 4 4 4 0 Tti2 family Arm PF00514.23 EDP44039.1 - 0.067 13.3 0.7 89 3.3 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Ecm29 PF13001.7 EDP44039.1 - 0.071 11.8 0.1 0.58 8.8 0.0 2.3 3 0 0 3 3 3 0 Proteasome stabiliser IFRD PF05004.13 EDP44039.1 - 0.078 12.1 0.1 0.23 10.5 0.0 1.8 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) UCH PF00443.29 EDP44040.1 - 5.1e-49 167.1 0.0 6.4e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP44040.1 - 7.4e-19 68.5 0.0 9.8e-18 64.8 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EDP44040.1 - 5.2e-06 26.1 0.1 0.15 11.6 0.1 2.9 2 1 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Peptidase_C14 PF00656.22 EDP44041.1 - 2.1e-59 201.5 0.0 2.7e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Caspase domain SH3_9 PF14604.6 EDP44042.1 - 2.5e-13 49.6 0.3 5.6e-13 48.5 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 EDP44042.1 - 2.2e-12 47.4 0.0 4.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 EDP44042.1 - 7e-12 44.8 0.1 1.9e-11 43.4 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 EDP44042.1 - 2.7e-07 30.6 0.0 4.5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 EDP44042.1 - 5.2e-06 26.0 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EDP44042.1 - 0.012 16.0 0.0 0.019 15.4 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 EDP44042.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EDP44042.1 - 0.2 11.9 0.2 0.36 11.1 0.2 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DnaJ PF00226.31 EDP44043.1 - 5.8e-20 71.2 1.9 1.4e-19 70.0 1.4 1.9 2 0 0 2 2 2 1 DnaJ domain KIAA1328 PF15369.6 EDP44043.1 - 0.086 12.7 4.9 0.1 12.4 4.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 NOB1_Zn_bind PF08772.11 EDP44044.1 - 7.8e-29 99.7 0.3 1.6e-28 98.7 0.3 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EDP44044.1 - 1.7e-27 95.7 0.0 3.1e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease TFIIA PF03153.13 EDP44044.1 - 0.0048 17.0 4.9 0.0048 17.0 4.9 2.0 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DZR PF12773.7 EDP44044.1 - 0.016 15.3 0.8 0.031 14.3 0.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon CDC45 PF02724.14 EDP44044.1 - 0.035 12.4 1.3 0.042 12.1 1.3 1.2 1 0 0 1 1 1 0 CDC45-like protein zf-NADH-PPase PF09297.11 EDP44044.1 - 0.2 11.4 3.5 5.5 6.7 0.3 2.7 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cwf_Cwc_15 PF04889.12 EDP44044.1 - 0.88 9.2 13.1 0.082 12.6 7.5 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 EDP44044.1 - 2.2 8.7 12.7 4.7 7.7 12.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WRNPLPNID PF15017.6 EDP44044.1 - 6.5 7.7 10.9 1.4 9.8 6.7 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DNA_pol_phi PF04931.13 EDP44044.1 - 9.2 4.2 7.6 13 3.8 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi MWFE PF15879.5 EDP44045.1 - 5.6e-25 87.3 0.1 7.4e-25 86.9 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit ox_reductase_C PF08635.10 EDP44046.1 - 2.1e-60 202.5 0.0 3.1e-60 202.0 0.0 1.2 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 EDP44046.1 - 1e-18 68.3 0.0 1.9e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDP44046.1 - 0.00036 20.5 0.0 0.00062 19.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Cofilin_ADF PF00241.20 EDP44047.1 - 7.5e-17 61.3 0.0 8e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ox_reductase_C PF08635.10 EDP44048.1 - 5.8e-74 246.4 0.0 8.4e-74 245.9 0.0 1.2 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 EDP44048.1 - 4.1e-23 82.5 0.0 7.7e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EDP44048.1 - 0.042 13.9 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Phage_portal PF04860.12 EDP44049.1 - 0.096 11.9 0.3 0.16 11.1 0.3 1.3 1 0 0 1 1 1 0 Phage portal protein Clathrin_lg_ch PF01086.17 EDP44051.1 - 2.6e-34 119.3 30.0 5.4e-32 111.7 30.0 2.2 1 1 0 1 1 1 1 Clathrin light chain Nucleo_P87 PF07267.11 EDP44051.1 - 1.7 7.4 12.3 2 7.2 12.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_L13 PF00572.18 EDP44052.1 - 2.4e-52 176.5 0.3 2.8e-52 176.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Cag12 PF13117.6 EDP44052.1 - 0.074 13.6 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 Cag pathogenicity island protein Cag12 CDC45 PF02724.14 EDP44053.1 - 0.24 9.7 2.7 0.24 9.6 2.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SMC_N PF02463.19 EDP44054.1 - 5.4e-18 65.2 0.0 8.5e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDP44054.1 - 5.1e-14 53.2 0.1 5.1e-14 53.2 0.1 4.2 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 EDP44054.1 - 3e-06 27.3 0.2 0.0079 16.0 0.0 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system CENP-F_leu_zip PF10473.9 EDP44054.1 - 0.00053 20.0 12.3 0.00053 20.0 12.3 5.9 6 0 0 6 6 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AbiTii PF18864.1 EDP44054.1 - 0.0013 18.9 0.1 0.03 14.5 0.0 2.6 2 0 0 2 2 2 1 AbiTii AAA_29 PF13555.6 EDP44054.1 - 0.0033 17.1 0.0 0.0077 15.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EDP44054.1 - 0.013 15.2 0.6 0.13 12.0 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EDP44054.1 - 0.1 13.1 0.0 0.1 13.1 0.0 3.9 3 2 0 4 4 3 0 ABC transporter AAA_27 PF13514.6 EDP44054.1 - 0.1 12.2 0.0 0.1 12.2 0.0 5.4 5 2 1 6 6 6 0 AAA domain BORCS7 PF16088.5 EDP44054.1 - 0.45 10.8 7.3 11 6.3 0.2 3.6 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 7 DUF19 PF01579.18 EDP44054.1 - 0.67 9.7 3.2 0.68 9.7 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF19) AAA PF00004.29 EDP44054.1 - 0.88 10.0 2.8 1.3 9.5 0.0 2.9 3 1 1 4 4 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDP44054.1 - 1 9.9 3.8 6.1 7.4 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_13 PF13166.6 EDP44054.1 - 4.1 5.9 42.6 3.6 6.1 0.0 4.5 4 1 0 4 4 4 0 AAA domain AAA_25 PF13481.6 EDP44054.1 - 4.3 6.9 7.9 0.57 9.7 0.0 3.4 2 1 1 3 3 3 0 AAA domain Cornichon PF03311.14 EDP44055.1 - 3.8e-50 169.3 13.8 4.4e-50 169.1 13.8 1.0 1 0 0 1 1 1 1 Cornichon protein CBFD_NFYB_HMF PF00808.23 EDP44056.1 - 5.8e-25 87.4 0.9 6.8e-25 87.1 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP44056.1 - 0.0021 18.4 0.3 0.0066 16.8 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 ABC_tran PF00005.27 EDP44057.1 - 1.1e-45 155.5 0.0 3e-22 79.6 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EDP44057.1 - 1.7e-20 72.8 3.5 1.7e-20 72.8 3.5 2.6 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EDP44057.1 - 4.6e-16 59.5 4.8 0.00096 19.0 0.1 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EDP44057.1 - 2.9e-12 47.5 0.4 0.00037 21.1 0.0 3.6 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.19 EDP44057.1 - 2.7e-09 36.8 2.2 0.25 10.8 0.1 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP44057.1 - 3.7e-08 33.0 3.5 0.00069 19.3 0.1 2.8 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EDP44057.1 - 1.4e-07 31.5 8.8 0.02 14.6 0.1 4.4 2 2 0 3 3 3 2 AAA ATPase domain AAA_16 PF13191.6 EDP44057.1 - 2.3e-07 31.3 0.0 0.036 14.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDP44057.1 - 2.4e-06 27.5 0.6 0.0037 17.2 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 EDP44057.1 - 2.5e-06 27.5 0.2 0.0057 16.7 0.1 3.1 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EDP44057.1 - 2.7e-05 24.5 0.3 0.53 10.5 0.1 2.9 2 2 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EDP44057.1 - 5.1e-05 23.1 0.1 1 9.1 0.0 3.4 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 EDP44057.1 - 6.3e-05 23.0 0.1 0.33 10.8 0.0 2.4 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 EDP44057.1 - 8e-05 22.9 0.0 0.21 11.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EDP44057.1 - 0.00023 21.3 5.9 0.36 10.9 0.3 4.0 3 1 1 4 4 4 2 Dynamin family DUF87 PF01935.17 EDP44057.1 - 0.00043 20.4 2.8 1.5 8.9 0.0 4.2 3 1 1 4 4 4 1 Helicase HerA, central domain FeoB_N PF02421.18 EDP44057.1 - 0.00053 19.5 0.1 0.029 13.9 0.1 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA PF00004.29 EDP44057.1 - 0.00065 20.1 0.0 2.9 8.3 0.0 3.8 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EDP44057.1 - 0.0019 18.0 0.7 0.99 9.1 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_18 PF13238.6 EDP44057.1 - 0.0024 18.4 0.2 1.1 9.8 0.0 3.0 2 1 1 3 3 2 1 AAA domain RNA_helicase PF00910.22 EDP44057.1 - 0.003 17.9 1.1 5.7 7.4 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Pox_A32 PF04665.12 EDP44057.1 - 0.0034 16.9 1.4 0.51 9.8 0.0 3.1 3 1 0 3 3 3 1 Poxvirus A32 protein Roc PF08477.13 EDP44057.1 - 0.004 17.4 0.0 3.7 7.8 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EDP44057.1 - 0.0047 17.1 0.1 1.8 8.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.15 EDP44057.1 - 0.006 16.5 0.5 1.9 8.3 0.1 3.5 3 0 0 3 3 3 1 NTPase FtsK_SpoIIIE PF01580.18 EDP44057.1 - 0.008 15.6 0.0 1.9 7.8 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_7 PF12775.7 EDP44057.1 - 0.012 15.1 0.2 4 6.9 0.1 3.1 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_5 PF07728.14 EDP44057.1 - 0.015 15.3 0.5 5.9 6.9 0.1 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EDP44057.1 - 0.018 14.6 0.0 4.5 6.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EDP44057.1 - 0.019 14.3 0.1 1.4 8.2 0.1 3.0 3 0 0 3 3 3 0 Zeta toxin Septin PF00735.18 EDP44057.1 - 0.022 14.1 1.8 5.1 6.3 0.1 2.9 3 0 0 3 3 3 0 Septin AAA_14 PF13173.6 EDP44057.1 - 0.022 14.8 0.3 9.6 6.3 0.0 3.6 4 1 0 4 4 4 0 AAA domain cobW PF02492.19 EDP44057.1 - 0.023 14.3 0.1 4.1 7.0 0.0 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EDP44057.1 - 0.025 13.8 0.0 2.6 7.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 EDP44057.1 - 0.028 14.1 0.0 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.9 EDP44057.1 - 0.06 13.1 1.0 12 5.6 0.0 3.3 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_27 PF13514.6 EDP44057.1 - 0.067 12.8 0.1 6.6 6.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EDP44057.1 - 0.085 12.6 0.0 6.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain SRP54 PF00448.22 EDP44057.1 - 0.11 12.1 1.5 4.4 6.9 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain MobB PF03205.14 EDP44057.1 - 0.12 12.3 3.3 10 6.0 0.0 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EDP44057.1 - 0.16 12.0 0.3 5.7 7.0 0.1 2.8 2 1 1 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 EDP44057.1 - 0.19 10.4 5.4 3.4 6.2 0.0 3.3 4 0 0 4 4 4 0 AAA domain MRP-L27 PF09809.9 EDP44058.1 - 0.00011 22.0 0.4 0.011 15.5 0.4 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 LRR_4 PF12799.7 EDP44060.1 - 1.6e-25 88.7 31.4 1.2e-08 35.1 1.2 5.5 5 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP44060.1 - 1.3e-18 66.5 27.7 2e-08 33.9 3.6 5.5 3 2 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EDP44060.1 - 2.1e-14 53.4 8.8 3.5e-07 29.9 0.8 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EDP44060.1 - 2e-06 27.4 20.6 1.2 9.3 0.3 8.8 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.33 EDP44060.1 - 0.0074 16.7 25.8 9.3 7.2 0.1 7.8 8 1 0 8 8 8 3 Leucine Rich Repeat F_actin_cap_B PF01115.17 EDP44061.1 - 7.2e-19 68.4 0.5 8.6e-19 68.1 0.5 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Latarcin PF10279.9 EDP44061.1 - 0.04 14.3 1.4 0.05 14.0 1.4 1.3 1 0 0 1 1 1 0 Latarcin precursor UDPGP PF01704.18 EDP44062.1 - 3e-168 559.8 0.0 5.2e-115 384.4 0.0 2.0 1 1 1 2 2 2 2 UTP--glucose-1-phosphate uridylyltransferase Mito_carr PF00153.27 EDP44063.1 - 2e-42 143.0 6.1 2.9e-16 59.1 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein MDM31_MDM32 PF08118.11 EDP44064.1 - 7.3e-165 549.6 0.0 1.4e-164 548.7 0.0 1.4 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Aim19 PF10315.9 EDP44065.1 - 6.4e-17 61.9 2.2 7.8e-17 61.6 2.2 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Thioesterase PF00975.20 EDP44068.1 - 0.22 11.6 2.0 12 5.9 0.2 2.3 2 1 0 2 2 2 0 Thioesterase domain Chitin_synth_2 PF03142.15 EDP44069.1 - 1.6e-228 759.6 0.2 2.4e-228 759.0 0.2 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EDP44069.1 - 1.5e-64 218.4 0.0 6.1e-55 186.7 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) Cyt-b5 PF00173.28 EDP44069.1 - 7e-15 54.9 0.0 1.8e-09 37.6 0.0 2.8 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EDP44069.1 - 3.6e-13 49.2 0.1 1.8e-12 47.0 0.2 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EDP44069.1 - 2.4e-10 40.6 3.4 2.4e-10 40.6 3.4 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EDP44069.1 - 7.6e-10 39.1 0.0 1.2e-08 35.1 0.0 2.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDP44069.1 - 2.4e-07 30.7 0.0 0.00055 19.8 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EDP44069.1 - 0.007 15.9 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 BPL_LplA_LipB PF03099.19 EDP44070.1 - 0.00028 20.8 0.0 0.00062 19.7 0.0 1.6 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF2277 PF10041.9 EDP44070.1 - 0.1 13.0 0.4 0.94 9.9 0.3 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2277) Cnd3 PF12719.7 EDP44071.1 - 3.3e-64 216.9 4.3 3.3e-64 216.9 4.3 2.2 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EDP44071.1 - 3e-07 30.7 10.5 0.00035 20.9 2.8 4.4 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EDP44071.1 - 3.1e-05 23.9 8.6 1.6 9.2 0.2 6.2 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EDP44071.1 - 0.00011 22.7 6.4 0.43 11.2 0.0 5.6 6 0 0 6 6 6 2 HEAT-like repeat Cnd1 PF12717.7 EDP44071.1 - 0.0013 18.8 3.7 0.032 14.3 0.1 3.5 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EDP44071.1 - 0.0017 18.5 2.2 2.6 8.2 0.1 3.6 2 2 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EDP44071.1 - 0.05 13.7 0.1 23 5.2 0.0 3.4 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EDP44071.1 - 0.091 11.3 1.1 0.77 8.2 0.2 2.2 2 0 0 2 2 2 0 Adaptin N terminal region BRO1 PF03097.18 EDP44072.1 - 1.8e-101 339.8 0.2 3e-101 339.0 0.2 1.4 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDP44072.1 - 6.5e-41 140.5 4.9 9.2e-41 140.1 4.9 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV TMPIT PF07851.13 EDP44072.1 - 0.2 10.8 0.0 0.34 10.1 0.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein zf-RING_2 PF13639.6 EDP44073.1 - 9e-13 48.3 10.7 1.4e-12 47.7 10.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDP44073.1 - 1.5e-08 34.8 8.0 2.9e-08 33.9 8.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EDP44073.1 - 2.5e-08 33.6 9.5 4e-08 33.0 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDP44073.1 - 2e-07 30.6 4.7 3.3e-07 29.9 4.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EDP44073.1 - 8.7e-07 28.7 8.1 1.4e-06 28.1 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP44073.1 - 1.3e-06 28.2 7.2 2e-06 27.6 7.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDP44073.1 - 1.9e-05 24.4 5.8 3.1e-05 23.7 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDP44073.1 - 2.2e-05 24.2 8.0 4.9e-05 23.1 8.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EDP44073.1 - 5.2e-05 23.2 3.6 9.7e-05 22.4 3.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EDP44073.1 - 0.0045 17.0 5.1 0.0087 16.1 5.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EDP44073.1 - 0.0076 15.8 8.3 0.016 14.8 8.3 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 EDP44073.1 - 0.053 13.6 3.1 0.099 12.7 3.1 1.4 1 0 0 1 1 1 0 Zinc-finger zf-HC5HC2H_2 PF13832.6 EDP44073.1 - 0.15 12.3 2.6 0.28 11.4 2.6 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDP44073.1 - 0.27 11.5 3.0 0.58 10.5 3.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING-like PF08746.11 EDP44073.1 - 0.44 10.9 9.1 0.77 10.1 9.1 1.4 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EDP44073.1 - 0.73 10.0 11.3 1.3 9.2 11.3 1.4 1 0 0 1 1 1 0 RING-variant domain DUF1272 PF06906.11 EDP44073.1 - 0.91 9.7 4.8 1.7 8.8 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 EDP44073.1 - 1.6 8.6 7.6 3 7.7 7.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EDP44073.1 - 2.6 8.3 6.6 6 7.1 6.6 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EDP44073.1 - 3.3 8.0 7.9 17 5.6 7.9 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF3102 PF11300.8 EDP44074.1 - 0.051 13.8 0.0 0.051 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) RNase_P_Rpp14 PF01900.19 EDP44076.1 - 1.6e-23 82.9 0.0 3.8e-23 81.7 0.0 1.6 2 0 0 2 2 2 1 Rpp14/Pop5 family SH3_1 PF00018.28 EDP44077.1 - 0.019 14.6 0.1 0.77 9.4 0.2 2.3 2 0 0 2 2 2 0 SH3 domain cobW PF02492.19 EDP44078.1 - 1.4e-47 161.6 0.4 7.9e-47 159.1 0.4 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain HIT PF01230.23 EDP44078.1 - 2.6e-24 85.8 0.0 5.6e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 HIT domain CobW_C PF07683.14 EDP44078.1 - 2.7e-21 75.3 0.1 9.1e-16 57.6 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain DcpS_C PF11969.8 EDP44078.1 - 6.6e-06 26.6 0.0 1.7e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding AAA_16 PF13191.6 EDP44078.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 EDP44078.1 - 0.02 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 EDP44078.1 - 0.04 13.8 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 EDP44078.1 - 0.063 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 EDP44078.1 - 0.2 11.4 0.2 0.67 9.7 0.2 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EDP44078.1 - 1.7 9.2 3.6 5.4 7.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain TFIIB PF00382.19 EDP44079.1 - 1.8e-33 114.4 0.1 2.9e-18 65.7 0.0 3.4 2 1 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EDP44079.1 - 5.4e-30 103.7 0.6 5.4e-30 103.7 0.6 2.5 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EDP44079.1 - 1.9e-08 33.7 0.2 1.9e-08 33.7 0.2 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.23 EDP44079.1 - 0.006 16.3 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain zf-ribbon_3 PF13248.6 EDP44079.1 - 3.8 7.1 4.6 2.8 7.5 2.1 2.2 2 1 1 3 3 3 0 zinc-ribbon domain FAM60A PF15396.6 EDP44079.1 - 4 7.4 12.3 0.16 12.0 0.3 2.8 1 1 2 3 3 3 0 Protein Family FAM60A zn-ribbon_14 PF16503.5 EDP44079.1 - 7 6.2 9.9 2.2 7.8 1.4 2.5 2 0 0 2 2 2 0 Zinc-ribbon HisG PF01634.18 EDP44080.1 - 1.5e-50 171.3 0.0 2e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EDP44080.1 - 6.8e-27 93.4 0.0 1.2e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EDP44080.1 - 0.015 15.2 0.0 0.023 14.7 0.0 1.4 1 1 0 1 1 1 0 NMT1/THI5 like SBP_bac_3 PF00497.20 EDP44080.1 - 0.17 11.3 0.0 0.39 10.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 AAA PF00004.29 EDP44081.1 - 8e-22 78.1 0.0 1.3e-21 77.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP44081.1 - 7e-13 48.2 0.0 1.4e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain FCH PF00611.23 EDP44081.1 - 0.073 13.4 0.0 0.22 11.8 0.0 1.8 1 1 1 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain TniB PF05621.11 EDP44081.1 - 0.092 12.1 0.0 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein Proteasome PF00227.26 EDP44082.1 - 4.5e-40 137.2 0.0 5.1e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Trans_coact PF16805.5 EDP44082.1 - 0.059 13.5 0.0 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Phage late-transcription coactivator Cation_efflux PF01545.21 EDP44083.1 - 1.6e-07 31.3 2.3 2.5e-07 30.6 2.3 1.4 1 1 0 1 1 1 1 Cation efflux family DNA_pol_delta_4 PF04081.13 EDP44084.1 - 6.3e-28 97.7 0.0 8.3e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 PsbQ PF05757.11 EDP44084.1 - 0.02 14.6 1.0 0.027 14.2 1.0 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) Met_10 PF02475.16 EDP44085.1 - 9.7e-60 201.7 0.0 1.3e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein zf-RING-like PF08746.11 EDP44085.1 - 0.003 17.8 3.9 0.064 13.6 0.2 2.5 2 0 0 2 2 2 2 RING-like domain Bromodomain PF00439.25 EDP44086.1 - 8.1e-21 73.9 0.0 1.6e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Bromodomain PTPRCAP PF15713.5 EDP44086.1 - 0.6 10.4 5.1 2 8.7 5.1 1.9 1 1 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Acyltransferase PF01553.21 EDP44087.1 - 1.6e-20 73.1 0.0 2.3e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase zf-Tim10_DDP PF02953.15 EDP44088.1 - 1.1e-21 76.2 2.0 1.5e-21 75.7 2.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Cytomega_TRL10 PF06084.11 EDP44088.1 - 0.019 15.0 1.3 0.022 14.8 0.8 1.4 1 1 0 1 1 1 0 Cytomegalovirus TRL10 protein Pil1 PF13805.6 EDP44089.1 - 2.7e-16 59.9 2.8 5.5e-16 58.8 2.8 1.5 1 0 0 1 1 1 1 Eisosome component PIL1 Dicty_REP PF05086.12 EDP44089.1 - 0.52 8.2 1.5 0.87 7.5 1.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MRG PF05712.13 EDP44090.1 - 1.2e-63 214.0 0.2 1.7e-63 213.5 0.2 1.2 1 0 0 1 1 1 1 MRG HNF-1_N PF04814.13 EDP44090.1 - 1.7 9.3 8.3 14 6.2 3.6 2.2 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Kinesin_assoc PF16183.5 EDP44090.1 - 1.7 8.7 4.3 1.8 8.7 1.6 2.0 2 0 0 2 2 2 0 Kinesin-associated SR-25 PF10500.9 EDP44090.1 - 3.2 7.3 24.3 0.056 13.1 8.2 2.5 2 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Period_C PF12114.8 EDP44090.1 - 5 6.7 16.4 0.81 9.2 6.7 2.3 2 0 0 2 2 2 0 Period protein 2/3C-terminal region BAR_2 PF10455.9 EDP44091.1 - 1.1e-45 156.0 0.1 1.7e-45 155.4 0.1 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EDP44091.1 - 1.9e-18 67.0 1.1 1.8e-11 44.1 0.1 2.1 2 0 0 2 2 2 2 BAR domain KapB PF08810.10 EDP44091.1 - 4.8e-05 23.5 4.9 0.002 18.3 0.2 2.6 2 1 0 2 2 2 1 Kinase associated protein B Syntaxin PF00804.25 EDP44091.1 - 0.0047 16.6 4.1 0.37 10.4 0.1 2.2 2 0 0 2 2 2 2 Syntaxin SKA2 PF16740.5 EDP44091.1 - 0.0052 16.6 1.6 0.013 15.2 0.1 2.3 2 1 0 2 2 2 1 Spindle and kinetochore-associated protein 2 bZIP_1 PF00170.21 EDP44091.1 - 0.0092 16.1 1.6 0.017 15.2 0.1 2.2 3 0 0 3 3 2 1 bZIP transcription factor GAS PF13851.6 EDP44091.1 - 0.0094 15.3 7.0 0.014 14.8 0.1 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EDP44091.1 - 0.019 15.2 9.8 0.25 11.6 2.2 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Allexi_40kDa PF05549.11 EDP44091.1 - 0.019 14.5 5.0 0.02 14.4 0.5 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein Seryl_tRNA_N PF02403.22 EDP44091.1 - 0.027 14.7 1.0 0.29 11.4 0.0 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain T3SSipB PF16535.5 EDP44091.1 - 0.035 14.6 7.3 0.047 14.2 0.3 2.7 2 2 0 2 2 2 0 Type III cell invasion protein SipB LPD39 PF18858.1 EDP44091.1 - 0.052 13.6 6.1 7.5 6.6 0.9 3.4 2 2 1 3 3 3 0 Large polyvalent protein associated domain 39 Fez1 PF06818.15 EDP44091.1 - 0.057 13.9 6.9 0.73 10.3 0.1 2.2 2 0 0 2 2 2 0 Fez1 DUF1048 PF06304.11 EDP44091.1 - 0.082 13.4 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) HSCB_C PF07743.13 EDP44091.1 - 0.11 13.0 5.5 1.7 9.2 0.3 3.6 2 2 1 3 3 3 0 HSCB C-terminal oligomerisation domain Phasin_2 PF09361.10 EDP44091.1 - 0.2 11.9 5.0 0.2 11.9 1.4 2.6 2 1 0 2 2 2 0 Phasin protein Tropomyosin_1 PF12718.7 EDP44091.1 - 0.24 11.5 4.7 2.7 8.1 0.2 2.5 2 0 0 2 2 2 0 Tropomyosin like Cytochrom_B562 PF07361.11 EDP44091.1 - 0.26 11.9 4.9 0.4 11.4 0.4 2.7 2 1 0 2 2 2 0 Cytochrome b562 YtzH PF14165.6 EDP44091.1 - 0.27 11.6 2.0 0.46 10.9 0.3 2.1 2 0 0 2 2 2 0 YtzH-like protein IFT57 PF10498.9 EDP44091.1 - 0.28 10.1 6.3 1.4 7.8 0.2 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 XhlA PF10779.9 EDP44091.1 - 0.66 10.2 2.6 8.1 6.7 0.2 2.5 2 1 0 2 2 2 0 Haemolysin XhlA TPR_MLP1_2 PF07926.12 EDP44091.1 - 0.77 9.8 11.7 0.53 10.3 0.2 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EDP44091.1 - 1.5 8.8 7.4 5.4 7.0 0.1 2.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EDP44091.1 - 2 8.6 4.4 29 4.8 0.2 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family zf-C4H2 PF10146.9 EDP44091.1 - 2 8.7 5.0 5.2 7.3 4.4 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein CENP-H PF05837.12 EDP44091.1 - 2 8.8 9.3 7 7.1 0.3 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) TMPIT PF07851.13 EDP44091.1 - 2.5 7.3 4.3 2.3 7.4 0.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein FUSC PF04632.12 EDP44091.1 - 2.7 6.4 12.9 2.2 6.7 1.9 2.4 2 1 0 2 2 2 0 Fusaric acid resistance protein family Syntaxin_2 PF14523.6 EDP44091.1 - 3 8.3 5.5 16 5.9 0.1 2.8 3 0 0 3 3 3 0 Syntaxin-like protein BST2 PF16716.5 EDP44091.1 - 3.7 8.2 6.9 6.8 7.4 1.5 2.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 CPSase_L_D2 PF02786.17 EDP44092.1 - 2.8e-112 373.3 0.1 3.8e-83 278.2 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain OTCace_N PF02729.21 EDP44092.1 - 9e-46 155.6 0.0 1.9e-45 154.5 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 EDP44092.1 - 1.3e-44 152.3 0.0 5.5e-44 150.2 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EDP44092.1 - 3.8e-41 140.3 0.0 8.2e-41 139.2 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain PF00988.22 EDP44092.1 - 3e-34 117.6 0.0 7.2e-34 116.4 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace PF00185.24 EDP44092.1 - 1.1e-28 100.3 0.0 1.9e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Dala_Dala_lig_C PF07478.13 EDP44092.1 - 3.1e-18 66.0 0.0 2.6e-09 36.9 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EDP44092.1 - 5.2e-15 55.4 0.0 8e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 EDP44092.1 - 7.7e-13 48.5 0.0 2.6e-12 46.8 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.6 EDP44092.1 - 1.1e-09 38.1 0.2 9.4e-05 22.2 0.0 2.8 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EDP44092.1 - 3.1e-06 27.3 0.1 0.01 15.9 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 EDP44092.1 - 0.00074 19.3 2.8 0.021 14.6 0.1 2.7 2 1 1 3 3 3 1 Peptidase C26 CBFD_NFYB_HMF PF00808.23 EDP44093.1 - 2.1e-17 63.1 0.3 3.3e-17 62.5 0.3 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP44093.1 - 0.00017 21.9 1.1 0.00022 21.6 0.2 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.14 EDP44093.1 - 0.0034 17.4 0.3 0.0055 16.8 0.3 1.4 1 1 0 1 1 1 1 hTAFII28-like protein conserved region CMS1 PF14617.6 EDP44094.1 - 2.1e-28 99.4 0.0 1e-23 84.0 0.0 2.1 1 1 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EDP44094.1 - 0.055 13.2 0.0 0.082 12.7 0.0 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF1708 PF08101.11 EDP44096.1 - 2.3e-17 63.3 1.4 2.3e-17 63.3 1.4 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF1708) RhoGAP PF00620.27 EDP44096.1 - 0.0013 18.6 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain zf-CSL PF05207.13 EDP44097.1 - 2.3e-21 75.3 1.1 3e-21 74.9 1.1 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 EDP44097.1 - 0.0016 18.5 0.7 0.0032 17.6 0.3 1.7 2 0 0 2 2 2 1 Zinc ribbon domain zf-RING_4 PF14570.6 EDP44097.1 - 0.019 14.7 2.1 0.02 14.7 0.5 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_7 PF02591.15 EDP44097.1 - 0.029 14.6 0.1 0.097 12.9 0.1 1.8 2 0 0 2 2 2 0 C4-type zinc ribbon domain zinc_ribbon_4 PF13717.6 EDP44097.1 - 0.038 13.9 0.3 0.058 13.3 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain RRM_1 PF00076.22 EDP44098.1 - 6.7e-05 22.6 0.0 0.00053 19.8 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4651 PF15513.6 EDP44098.1 - 0.092 12.6 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4651) DUF883 PF05957.13 EDP44098.1 - 0.5 11.0 4.3 1.8 9.2 3.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Rad60-SLD PF11976.8 EDP44099.1 - 9e-20 70.3 1.5 4.5e-17 61.6 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EDP44099.1 - 7.4e-10 38.4 0.1 4.2e-09 36.0 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family TPR_1 PF00515.28 EDP44100.1 - 8.4e-37 123.5 17.3 4.2e-06 26.3 0.1 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44100.1 - 3.9e-32 107.7 21.7 0.00016 21.5 0.0 11.0 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44100.1 - 6.8e-24 82.0 13.6 0.00031 20.7 0.0 10.6 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44100.1 - 4.3e-19 68.6 20.2 0.0009 19.5 0.0 7.8 3 3 6 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44100.1 - 7.1e-18 65.0 16.6 3.9e-05 24.2 0.0 7.5 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44100.1 - 5.1e-16 58.1 19.1 2.8e-06 26.9 0.0 8.2 7 1 2 9 9 9 5 TPR repeat TPR_17 PF13431.6 EDP44100.1 - 2.7e-15 55.6 6.4 0.2 12.1 0.0 8.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44100.1 - 3.5e-12 46.1 18.5 0.12 13.3 0.4 10.1 4 4 7 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44100.1 - 4.1e-12 46.4 18.9 0.0015 19.0 0.3 7.5 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDP44100.1 - 6.7e-09 35.8 5.0 0.00017 21.6 0.1 5.2 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44100.1 - 5.5e-07 29.7 11.5 0.15 12.3 0.0 5.8 2 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EDP44100.1 - 5.6e-07 29.1 14.4 3.1 8.0 0.0 8.5 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDP44100.1 - 1.1e-05 25.1 17.3 4.9 7.2 0.0 8.5 8 0 0 8 8 8 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDP44100.1 - 0.00041 19.7 3.8 2.6 7.6 0.1 5.5 5 0 0 5 5 5 1 SHNi-TPR TPR_15 PF13429.6 EDP44100.1 - 0.01 15.1 9.5 0.34 10.1 0.2 4.3 2 1 0 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 EDP44100.1 - 0.031 14.4 7.9 0.034 14.2 0.8 3.7 4 0 0 4 4 4 0 MAS20 protein import receptor HTH_ParB PF17762.1 EDP44100.1 - 0.04 13.7 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 HTH domain found in ParB protein NARP1 PF12569.8 EDP44100.1 - 0.061 12.2 13.3 0.13 11.2 0.0 3.8 2 2 2 4 4 4 0 NMDA receptor-regulated protein 1 Sel1 PF08238.12 EDP44100.1 - 0.13 13.0 2.3 87 4.0 0.1 4.0 3 0 0 3 3 3 0 Sel1 repeat Sox_N PF12444.8 EDP44100.1 - 0.34 12.1 7.4 1.1 10.5 7.4 1.9 1 0 0 1 1 1 0 Sox developmental protein N terminal MIT PF04212.18 EDP44100.1 - 0.48 10.5 14.2 2.4 8.3 0.5 4.8 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain DUF5102 PF17104.5 EDP44100.1 - 3.6 7.5 11.6 0.088 12.8 3.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5102) CRAL_TRIO PF00650.20 EDP44101.1 - 1.1e-24 86.9 0.0 1.7e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDP44101.1 - 5e-06 26.6 0.4 0.00023 21.3 0.0 2.6 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain ORC6 PF05460.13 EDP44101.1 - 0.088 12.1 1.1 0.12 11.6 1.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) EOS1 PF12326.8 EDP44102.1 - 4.8e-60 202.5 7.2 2.2e-59 200.3 7.2 2.0 1 1 0 1 1 1 1 N-glycosylation protein Mago_nashi PF02792.14 EDP44103.1 - 4.9e-17 62.4 0.6 1.1e-11 45.0 0.0 2.2 2 0 0 2 2 2 2 Mago nashi protein Cpn10 PF00166.21 EDP44104.1 - 1.6e-10 40.9 0.0 1.7e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 EDP44105.1 - 1.4e-90 304.3 7.4 2.4e-90 303.5 7.4 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mito_carr PF00153.27 EDP44106.1 - 7.5e-70 230.9 0.4 4.9e-24 84.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SMC_N PF02463.19 EDP44107.1 - 1.3e-25 90.2 0.0 1.7e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EDP44107.1 - 1.2e-05 25.2 0.3 4.8e-05 23.3 0.2 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EDP44107.1 - 0.21 12.1 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 ABC transporter SMC_N PF02463.19 EDP44108.1 - 3e-41 141.3 0.2 7e-41 140.1 0.2 1.6 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDP44108.1 - 3.1e-12 47.4 14.8 3.1e-12 47.4 14.8 4.2 2 2 0 2 2 1 1 AAA domain SMC_hinge PF06470.13 EDP44108.1 - 5.1e-12 46.1 0.0 1.9e-11 44.3 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EDP44108.1 - 4.6e-08 33.2 0.1 1.2e-07 31.8 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDP44108.1 - 1.9e-05 24.7 0.1 3.6e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP44108.1 - 2.5e-05 23.9 0.0 8.2e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain EzrA PF06160.12 EDP44108.1 - 0.00065 18.0 9.2 0.00065 18.0 9.2 3.7 2 1 2 4 4 4 2 Septation ring formation regulator, EzrA HIP1_clath_bdg PF16515.5 EDP44108.1 - 0.018 15.6 6.3 0.018 15.6 6.3 7.5 3 2 3 7 7 6 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HALZ PF02183.18 EDP44108.1 - 0.064 13.5 3.4 1.7 8.9 0.9 3.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper Filament PF00038.21 EDP44108.1 - 0.5 9.9 68.0 0.029 13.9 26.1 4.5 2 1 2 4 4 4 0 Intermediate filament protein Golgin_A5 PF09787.9 EDP44108.1 - 1.8 8.0 66.3 0.032 13.7 13.1 4.5 2 2 2 4 4 4 0 Golgin subfamily A member 5 DNA_ligase_A_N PF04675.14 EDP44109.1 - 4.2e-45 154.2 0.3 6.8e-45 153.5 0.3 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 EDP44109.1 - 4.8e-25 88.4 0.0 1.8e-22 80.0 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 EDP44109.1 - 1.5e-24 86.4 0.0 4e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 EDP44109.1 - 0.086 12.9 0.2 12 6.0 0.0 2.7 2 0 0 2 2 2 0 DNA ligase OB-like domain eIF-3c_N PF05470.12 EDP44109.1 - 0.1 10.9 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Peptidase_M48_N PF16491.5 EDP44110.1 - 1.8e-52 177.9 3.2 2.8e-52 177.3 3.2 1.3 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EDP44110.1 - 5.9e-21 75.1 0.4 1.4e-20 73.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M48 SprT-like PF10263.9 EDP44110.1 - 0.071 13.0 0.4 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 SprT-like family DUF2268 PF10026.9 EDP44110.1 - 0.087 12.4 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Peptidase_M48_N PF16491.5 EDP44111.1 - 4.1e-21 75.7 1.8 4.1e-21 75.7 1.8 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EDP44111.1 - 2.4e-11 43.8 1.5 9.6e-11 41.8 1.5 2.1 1 1 0 1 1 1 1 Peptidase family M48 Lact_bio_phlase PF09508.10 EDP44111.1 - 0.089 11.2 0.9 0.14 10.6 0.9 1.2 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain GTP_EFTU PF00009.27 EDP44112.1 - 1.4e-58 197.6 0.2 3.8e-58 196.2 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EDP44112.1 - 1.9e-39 134.2 0.0 3.9e-39 133.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EDP44112.1 - 9.5e-31 105.7 0.0 2.2e-30 104.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EDP44112.1 - 1.4e-23 82.7 0.1 3.7e-23 81.4 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EDP44112.1 - 2.3e-12 47.1 0.1 6.2e-12 45.7 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EDP44112.1 - 7.1e-06 25.9 0.0 1.9e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain TFIID-18kDa PF02269.16 EDP44113.1 - 7.3e-14 51.6 0.1 3.1e-10 39.9 0.1 2.5 2 0 0 2 2 2 2 Transcription initiation factor IID, 18kD subunit Occludin_ELL PF07303.13 EDP44114.1 - 1.1 10.1 5.1 28 5.5 0.0 3.5 2 1 1 3 3 3 0 Occludin homology domain DHR10 PF18595.1 EDP44114.1 - 1.2 9.3 14.7 0.04 14.0 1.8 3.6 4 0 0 4 4 4 0 Designed helical repeat protein 10 domain Nnf1 PF03980.14 EDP44114.1 - 1.8 9.0 9.6 1.7 9.1 0.1 2.9 2 1 0 2 2 2 0 Nnf1 GAS PF13851.6 EDP44114.1 - 1.9 7.8 6.5 3.6 6.9 4.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding PLA2_B PF01735.18 EDP44115.1 - 6.4e-17 61.1 0.0 5.7e-09 34.9 0.1 3.2 3 0 0 3 3 3 3 Lysophospholipase catalytic domain Ribosomal_S10 PF00338.22 EDP44116.1 - 6.1e-23 80.9 0.0 1.3e-22 79.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e BTB_2 PF02214.22 EDP44118.1 - 0.0002 21.7 0.0 0.0049 17.2 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain Synaptobrevin PF00957.21 EDP44119.1 - 1.4e-07 31.2 6.6 0.00012 21.8 0.1 3.2 2 1 1 3 3 3 2 Synaptobrevin DUF4618 PF15397.6 EDP44119.1 - 0.071 12.5 0.1 0.091 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) FAM24 PF15193.6 EDP44119.1 - 0.12 13.1 0.0 0.22 12.3 0.0 1.4 1 0 0 1 1 1 0 FAM24 family Septin PF00735.18 EDP44120.1 - 3.6e-101 338.1 0.1 4.9e-101 337.7 0.1 1.1 1 0 0 1 1 1 1 Septin GTP_EFTU PF00009.27 EDP44120.1 - 0.0075 15.8 0.1 0.52 9.8 0.0 2.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Cep57_CLD_2 PF14197.6 EDP44120.1 - 6.1 7.0 8.1 0.24 11.5 1.3 2.2 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 SF3A2 PF16835.5 EDP44121.1 - 1.8e-31 108.4 0.0 9.7e-31 106.0 0.0 2.0 1 1 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EDP44121.1 - 9e-07 29.1 0.7 2.3e-06 27.8 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Pyr_redox_2 PF07992.14 EDP44122.1 - 4.1e-12 45.9 0.0 6.8e-09 35.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP44122.1 - 9.4e-05 22.4 1.6 0.0024 17.9 0.0 3.6 3 2 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EDP44122.1 - 0.0093 16.2 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EDP44122.1 - 0.013 14.8 0.0 10 5.3 0.0 3.0 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 EDP44122.1 - 0.031 13.4 0.3 5.7 6.0 0.0 2.9 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EDP44122.1 - 0.066 12.5 0.0 1.4 8.1 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP44122.1 - 0.07 13.7 0.0 2.7 8.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDP44122.1 - 0.083 11.6 0.0 1.1 7.9 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein UPF0172 PF03665.13 EDP44123.1 - 3.1e-44 151.3 0.0 4e-44 150.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 EDP44123.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ras PF00071.22 EDP44124.1 - 1.2e-54 184.3 0.0 1.4e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP44124.1 - 3.4e-28 98.3 0.0 5.3e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP44124.1 - 1.1e-14 54.3 0.0 1.4e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDP44124.1 - 9e-06 25.7 0.0 0.028 14.3 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EDP44124.1 - 6.7e-05 23.0 0.0 9.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EDP44124.1 - 0.00062 19.2 0.0 0.00073 18.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EDP44124.1 - 0.006 16.1 0.0 0.014 14.9 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EDP44124.1 - 0.0067 16.8 0.1 0.0075 16.7 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EDP44124.1 - 0.0086 16.4 0.0 0.019 15.2 0.0 1.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EDP44124.1 - 0.015 15.4 0.0 0.023 14.8 0.0 1.3 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EDP44124.1 - 0.025 14.0 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 EDP44124.1 - 0.035 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 EDP44124.1 - 0.036 13.8 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EDP44124.1 - 0.048 13.7 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EDP44124.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EDP44124.1 - 0.091 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 EDP44124.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TruD PF01142.18 EDP44125.1 - 1.1e-62 212.3 0.0 1.3e-30 106.5 0.0 3.9 3 1 0 3 3 3 3 tRNA pseudouridine synthase D (TruD) CCDC53 PF10152.9 EDP44125.1 - 0.017 15.6 0.1 0.87 10.0 0.0 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Ammonium_transp PF00909.21 EDP44126.1 - 2.5e-105 352.5 24.1 2.9e-105 352.2 24.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family ENTH PF01417.20 EDP44127.1 - 8.7e-46 155.0 0.3 1.6e-45 154.1 0.3 1.5 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDP44127.1 - 0.0001 21.4 0.8 0.00018 20.6 0.8 1.7 1 1 0 1 1 1 1 ANTH domain DRMBL PF07522.14 EDP44127.1 - 0.11 12.6 2.4 1.2 9.4 0.3 2.4 1 1 1 2 2 2 0 DNA repair metallo-beta-lactamase GlyL_C PF12524.8 EDP44127.1 - 0.17 12.0 7.3 0.097 12.8 3.6 2.4 1 1 1 2 2 2 0 dsDNA virus glycoprotein L C terminal UIM PF02809.20 EDP44127.1 - 0.28 11.2 15.5 0.14 12.1 5.1 3.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Na_Ca_ex PF01699.24 EDP44128.1 - 5.3e-26 91.4 31.5 8.1e-18 64.8 14.2 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein MatE PF01554.18 EDP44128.1 - 0.0032 17.1 0.6 0.0032 17.1 0.6 2.9 2 1 1 3 3 3 1 MatE Pkinase PF00069.25 EDP44129.1 - 1.5e-72 244.2 0.0 2.1e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44129.1 - 8.2e-34 117.0 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EDP44129.1 - 9.7e-14 51.8 0.0 4.3e-13 49.8 0.0 2.1 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 EDP44129.1 - 7.5e-08 32.0 0.0 1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDP44129.1 - 0.093 12.1 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EDP44129.1 - 0.1 11.5 0.1 0.18 10.7 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Plasmodium_Vir PF05795.11 EDP44129.1 - 0.26 10.7 1.0 0.7 9.3 0.8 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein TPR_1 PF00515.28 EDP44130.1 - 7.2e-06 25.6 2.1 0.00066 19.4 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44130.1 - 2.2e-05 24.2 15.2 0.00022 21.1 0.2 6.4 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44130.1 - 0.00021 21.2 1.8 0.41 11.0 0.1 5.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44130.1 - 0.00064 19.4 1.6 3.4 7.4 0.0 4.1 5 0 0 5 5 5 2 TPR repeat TPR_17 PF13431.6 EDP44130.1 - 0.0041 17.4 1.3 3.4 8.3 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44130.1 - 0.022 15.6 1.0 0.022 15.6 1.0 9.0 8 1 2 10 10 10 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44130.1 - 1.2 9.4 3.9 30 4.9 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EDP44130.1 - 4.7 7.2 6.0 35 4.4 0.3 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Tubulin PF00091.25 EDP44131.1 - 1.6e-70 237.3 0.0 3.7e-70 236.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EDP44131.1 - 8.5e-41 139.1 0.6 1.3e-40 138.4 0.6 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EDP44131.1 - 1.1e-06 29.0 0.0 2.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EDP44131.1 - 0.00043 20.0 0.0 0.0011 18.7 0.0 1.7 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EDP44131.1 - 0.0083 15.3 0.0 0.021 14.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin like Sacchrp_dh_C PF16653.5 EDP44132.1 - 1.1e-84 284.7 0.0 1.8e-83 280.7 0.0 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Spermine_synth PF01564.17 EDP44132.1 - 2.5e-65 219.4 0.0 1e-64 217.5 0.0 1.9 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EDP44132.1 - 5.2e-24 83.9 0.0 1.1e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Sacchrp_dh_NADP PF03435.18 EDP44132.1 - 2.2e-22 79.7 0.7 6.6e-22 78.2 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Methyltransf_25 PF13649.6 EDP44132.1 - 0.00016 22.3 0.0 0.017 15.8 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_10 PF13460.6 EDP44132.1 - 0.00029 20.8 0.1 0.00055 19.9 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EDP44132.1 - 0.00032 21.1 0.1 0.0015 19.0 0.1 2.0 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDP44132.1 - 0.0015 18.6 0.0 0.0083 16.2 0.0 2.2 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Methyltransf_12 PF08242.12 EDP44132.1 - 0.0084 16.8 0.2 0.7 10.7 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain 3Beta_HSD PF01073.19 EDP44132.1 - 0.026 13.5 0.0 0.058 12.4 0.0 1.5 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family AlaDh_PNT_C PF01262.21 EDP44132.1 - 0.06 12.6 0.0 0.27 10.5 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Eno-Rase_NADH_b PF12242.8 EDP44132.1 - 0.17 11.7 0.0 31 4.4 0.0 2.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CENP-B_dimeris PF09026.10 EDP44133.1 - 0.00029 21.2 5.3 0.00055 20.3 5.3 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain TAFII28 PF04719.14 EDP44133.1 - 0.0037 17.3 0.0 0.0066 16.5 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region NPR3 PF03666.13 EDP44133.1 - 0.0072 15.2 2.8 0.0078 15.1 2.8 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF2722 PF10846.8 EDP44133.1 - 0.064 12.2 4.6 0.062 12.2 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Dicty_REP PF05086.12 EDP44133.1 - 4.2 5.2 4.3 5.1 5.0 4.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 EDP44133.1 - 5 5.8 4.4 5.4 5.7 4.4 1.1 1 0 0 1 1 1 0 Presenilin Cwf_Cwc_15 PF04889.12 EDP44133.1 - 8.6 6.0 18.3 12 5.6 18.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 EDP44133.1 - 9.3 4.3 15.2 12 3.9 15.2 1.1 1 0 0 1 1 1 0 Nop14-like family Ank_2 PF12796.7 EDP44134.1 - 1.3e-25 89.8 0.0 1.1e-14 54.8 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EDP44134.1 - 1.7e-25 86.2 1.0 1.1e-05 25.4 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EDP44134.1 - 3.3e-24 84.2 7.5 1.6e-07 31.4 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EDP44134.1 - 2.5e-23 81.8 3.9 4.9e-10 39.5 0.4 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EDP44134.1 - 7.3e-22 77.4 4.4 7.7e-11 42.3 0.2 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) SQHop_cyclase_N PF13249.6 EDP44135.1 - 9.9e-50 169.3 0.2 4.7e-39 134.2 0.1 3.8 3 1 0 4 4 4 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EDP44135.1 - 2.6e-44 151.6 0.1 4.6e-41 141.0 0.1 2.6 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 EDP44135.1 - 1.5e-32 111.0 6.5 1.2e-09 37.7 0.2 7.1 7 0 0 7 7 7 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EDP44135.1 - 9e-06 24.9 0.0 0.0097 15.0 0.0 3.3 3 1 1 4 4 4 2 A-macroglobulin TED domain Pec_lyase PF09492.10 EDP44135.1 - 0.0055 16.1 0.4 4.8 6.4 0.0 3.1 3 1 1 4 4 4 2 Pectic acid lyase Mago-bind PF09282.10 EDP44135.1 - 0.27 11.1 0.7 1.5 8.8 0.0 2.5 3 0 0 3 3 3 0 Mago binding MTS PF05175.14 EDP44136.1 - 2.3e-09 37.0 0.0 3.2e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EDP44136.1 - 9.8e-07 28.7 0.0 1.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP44136.1 - 2.1e-05 25.1 0.1 5.1e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EDP44136.1 - 0.00015 21.5 0.1 0.00081 19.1 0.0 1.9 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EDP44136.1 - 0.0009 18.6 0.0 0.0012 18.2 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_24 PF13578.6 EDP44136.1 - 0.003 18.6 0.8 0.003 18.6 0.8 2.0 2 1 0 2 2 2 1 Methyltransferase domain TrkA_N PF02254.18 EDP44136.1 - 0.004 17.4 0.1 0.0073 16.6 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EDP44136.1 - 0.0061 16.8 0.2 0.014 15.7 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Methyltransf_11 PF08241.12 EDP44136.1 - 0.0089 16.6 0.3 0.022 15.4 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP44136.1 - 0.01 16.6 0.1 0.021 15.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmC_N PF17827.1 EDP44136.1 - 0.01 16.4 0.4 0.028 15.0 0.4 1.8 1 1 0 1 1 1 0 PrmC N-terminal domain PrmA PF06325.13 EDP44136.1 - 0.013 14.9 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) N6-adenineMlase PF10237.9 EDP44136.1 - 0.02 14.7 0.0 0.027 14.3 0.0 1.5 1 1 0 1 1 1 0 Probable N6-adenine methyltransferase CheR PF01739.18 EDP44136.1 - 0.032 13.7 0.2 0.84 9.1 0.1 2.3 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Eco57I PF07669.11 EDP44136.1 - 0.11 13.0 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Pex16 PF08610.10 EDP44137.1 - 1.9e-107 359.2 0.1 3.2e-107 358.4 0.1 1.4 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) ATG13 PF10033.9 EDP44138.1 - 5.5e-25 88.4 0.0 1.8e-24 86.8 0.0 1.8 1 1 0 1 1 1 1 Autophagy-related protein 13 Pkinase PF00069.25 EDP44139.1 - 8.9e-60 202.3 0.0 1.1e-59 202.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44139.1 - 1e-36 126.6 0.0 3.5e-35 121.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44139.1 - 2.7e-05 23.6 0.0 4.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDP44139.1 - 0.0037 16.3 0.0 0.0057 15.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDP44139.1 - 0.0064 15.3 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDP44139.1 - 0.0089 16.0 0.0 0.58 10.0 0.0 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDP44139.1 - 0.095 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Glyco_transf_22 PF03901.17 EDP44140.1 - 5e-75 253.3 29.3 5.4e-75 253.2 29.3 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ERCC4 PF02732.15 EDP44141.1 - 3.3e-15 56.6 0.1 9.5e-15 55.1 0.0 1.7 2 0 0 2 2 2 1 ERCC4 domain NatB_MDM20 PF09797.9 EDP44142.1 - 6.9e-46 156.9 0.0 1e-45 156.4 0.0 1.2 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Med14 PF08638.11 EDP44143.1 - 2.7e-46 157.4 0.1 7.6e-46 155.9 0.0 1.9 2 0 0 2 2 2 1 Mediator complex subunit MED14 HEAT PF02985.22 EDP44144.1 - 8.3e-06 25.6 1.3 0.34 11.3 0.0 4.7 4 0 0 4 4 4 1 HEAT repeat Pkinase PF00069.25 EDP44144.1 - 0.0031 16.9 0.0 0.03 13.7 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain HEAT_2 PF13646.6 EDP44144.1 - 0.02 15.3 1.5 3.4 8.1 0.1 2.9 2 1 1 3 3 3 0 HEAT repeats CLASP_N PF12348.8 EDP44144.1 - 0.036 13.6 0.2 0.54 9.8 0.2 2.3 1 1 0 1 1 1 0 CLASP N terminal SIR2 PF02146.17 EDP44145.1 - 8.4e-20 71.4 2.1 9e-14 51.8 0.1 2.2 1 1 1 2 2 2 2 Sir2 family Mito_carr PF00153.27 EDP44146.1 - 1.8e-08 34.2 0.0 0.081 12.8 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Herpes_LMP1 PF05297.11 EDP44146.1 - 0.39 9.9 2.0 0.65 9.1 2.0 1.5 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF3328 PF11807.8 EDP44146.1 - 0.48 10.2 3.8 0.44 10.3 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) DUF1218 PF06749.12 EDP44146.1 - 1.3 9.6 7.5 0.48 11.0 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) KCH PF16944.5 EDP44146.1 - 2.4 7.8 9.1 14 5.3 0.5 3.1 3 0 0 3 3 3 0 Fungal potassium channel Mito_carr PF00153.27 EDP44147.1 - 1.6e-11 43.9 0.4 0.0007 19.5 0.0 3.7 3 1 0 3 3 3 2 Mitochondrial carrier protein PRA1 PF03208.19 EDP44148.1 - 1.7e-13 50.4 9.1 2e-13 50.2 9.1 1.0 1 0 0 1 1 1 1 PRA1 family protein EBP PF05241.12 EDP44148.1 - 0.1 12.1 3.1 0.13 11.8 3.1 1.1 1 0 0 1 1 1 0 Emopamil binding protein Telomerase_RBD PF12009.8 EDP44149.1 - 1.9e-32 112.2 1.0 3.7e-32 111.2 1.0 1.5 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EDP44149.1 - 2.2e-11 43.7 0.0 8.6e-07 28.7 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Lact_bio_phlase PF09508.10 EDP44150.1 - 0.23 9.8 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain WD40 PF00400.32 EDP44151.1 - 2.2e-63 208.7 21.9 5.1e-06 27.1 1.1 11.4 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 EDP44151.1 - 1.5e-53 180.6 0.5 2.3e-53 179.9 0.5 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EDP44151.1 - 3.3e-15 56.1 3.0 0.031 14.6 0.0 6.9 4 2 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP44151.1 - 3.8e-06 25.9 12.7 0.059 12.0 0.7 6.4 5 2 1 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 EDP44151.1 - 2.6e-05 23.7 0.0 0.2 11.0 0.0 4.1 3 1 1 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 EDP44151.1 - 4.8e-05 22.3 0.2 1.5 7.5 0.0 4.6 3 2 0 3 3 3 2 Nup133 N terminal like VID27 PF08553.10 EDP44151.1 - 0.075 12.1 0.1 0.32 10.0 0.0 1.9 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain SF3b1 PF08920.10 EDP44152.1 - 1.8e-20 73.6 5.6 1.8e-20 73.6 5.6 3.2 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 EDP44152.1 - 6.5e-15 55.3 19.5 0.00064 20.1 0.3 9.0 6 3 4 10 10 10 5 HEAT repeats HEAT_EZ PF13513.6 EDP44152.1 - 1.9e-11 44.2 13.1 0.016 15.7 0.0 8.3 7 1 1 8 8 8 2 HEAT-like repeat Adaptin_N PF01602.20 EDP44152.1 - 1.4e-08 33.8 2.0 0.089 11.3 0.2 3.9 3 1 0 4 4 4 3 Adaptin N terminal region HEAT PF02985.22 EDP44152.1 - 1.6e-07 31.0 15.9 0.32 11.4 0.0 10.2 12 0 0 12 12 11 2 HEAT repeat NUC173 PF08161.12 EDP44152.1 - 8.4e-06 25.6 1.8 0.48 10.1 0.0 4.6 3 2 1 4 4 4 2 NUC173 domain CLASP_N PF12348.8 EDP44152.1 - 1.5e-05 24.7 3.4 0.077 12.5 0.0 3.5 3 0 0 3 3 3 2 CLASP N terminal Cnd1 PF12717.7 EDP44152.1 - 2.4e-05 24.4 7.6 0.15 12.1 0.1 6.0 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDP44152.1 - 0.00011 22.8 2.8 10 6.8 0.0 5.5 7 0 0 7 7 6 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EDP44152.1 - 0.00052 20.0 0.1 2.9 7.8 0.1 4.1 3 2 0 3 3 3 2 Domain of unknown function (DUF3385) IFRD PF05004.13 EDP44152.1 - 0.0011 18.2 0.0 0.33 10.0 0.0 3.0 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) MMS19_C PF12460.8 EDP44152.1 - 0.0017 17.5 0.0 4.7 6.2 0.0 3.5 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 EDP44152.1 - 0.002 17.3 0.4 0.28 10.2 0.0 3.5 4 0 0 4 4 4 1 Dopey, N-terminal DUF3730 PF12530.8 EDP44152.1 - 0.0054 16.3 0.1 0.025 14.1 0.0 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3730) Tudor-knot PF11717.8 EDP44153.1 - 2.8e-19 68.7 0.4 4.8e-19 68.0 0.4 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Glyco_tran_28_C PF04101.16 EDP44153.1 - 0.028 14.4 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain DcpS_C PF11969.8 EDP44153.1 - 0.12 12.9 0.1 0.18 12.3 0.1 1.2 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding MOZ_SAS PF01853.18 EDP44154.1 - 1.3e-83 279.1 0.2 1.5e-83 278.8 0.2 1.0 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 EDP44154.1 - 0.0027 18.1 0.0 0.0054 17.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP44154.1 - 0.014 15.6 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HTH_6 PF01418.17 EDP44154.1 - 0.11 12.4 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family FR47 PF08445.10 EDP44154.1 - 0.15 12.0 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein RRM_1 PF00076.22 EDP44155.1 - 6.8e-06 25.8 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EDP44155.1 - 0.022 15.6 0.0 0.051 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II-binding domain. REV PF00424.18 EDP44155.1 - 0.21 11.7 2.0 0.24 11.5 0.6 1.8 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Ribosomal_S2 PF00318.20 EDP44156.1 - 2.1e-28 99.1 0.1 3.2e-14 52.7 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EDP44156.1 - 2.6e-10 41.5 8.0 4.5e-10 40.8 8.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ring_hydroxyl_A PF00848.19 EDP44156.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) Ribosomal_S5 PF00333.20 EDP44157.1 - 2.9e-27 94.4 0.8 8.2e-27 93.0 0.4 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EDP44157.1 - 1.5e-21 75.6 0.0 2.7e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain F1F0-ATPsyn_F PF10791.9 EDP44158.1 - 5.8e-29 100.4 0.1 7.9e-28 96.8 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi BRO1 PF03097.18 EDP44159.1 - 1.3e-11 43.9 0.1 1.6e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 BRO1-like domain Med27 PF11571.8 EDP44159.1 - 0.031 14.6 0.7 0.58 10.6 0.3 2.4 2 0 0 2 2 2 0 Mediator complex subunit 27 IMS PF00817.20 EDP44160.1 - 2.9e-43 147.4 0.4 5e-43 146.7 0.4 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EDP44160.1 - 1.8e-08 35.1 1.7 4.3e-08 33.9 0.1 2.3 3 0 0 3 3 3 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EDP44160.1 - 0.00013 22.0 0.0 0.00036 20.7 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Peptidase_C54 PF03416.19 EDP44161.1 - 5.2e-96 321.3 0.0 6.8e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 NAP PF00956.18 EDP44162.1 - 5.8e-89 297.9 0.2 7.4e-89 297.5 0.2 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Protocadherin PF08374.11 EDP44162.1 - 0.21 11.5 0.7 0.73 9.8 0.1 1.9 2 0 0 2 2 2 0 Protocadherin RNA_pol_3_Rpc31 PF11705.8 EDP44162.1 - 0.61 10.3 26.0 3.3 7.9 13.6 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Vps53_N PF04100.12 EDP44163.1 - 1.2e-78 264.8 0.2 2.1e-78 263.9 0.2 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.13 EDP44163.1 - 7.4e-05 21.3 0.1 0.1 11.0 0.0 2.4 2 0 0 2 2 2 2 Exocyst complex component Sec6 Vps54_N PF10475.9 EDP44163.1 - 0.042 13.1 0.6 0.079 12.2 0.6 1.4 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex TORC_C PF12886.7 EDP44163.1 - 0.14 12.8 0.2 15 6.2 0.0 2.7 2 0 0 2 2 2 0 Transducer of regulated CREB activity, C terminus KH_6 PF15985.5 EDP44164.1 - 2e-08 34.5 0.0 3.1e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EDP44164.1 - 1.4e-05 25.0 3.4 4.3e-05 23.3 3.4 1.8 1 1 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Prot_ATP_ID_OB PF16450.5 EDP44164.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain RsgA_N PF16745.5 EDP44164.1 - 0.099 12.4 0.0 14 5.5 0.0 2.4 2 0 0 2 2 2 0 RsgA N-terminal domain NOA36 PF06524.12 EDP44164.1 - 0.55 9.5 5.8 0.76 9.0 5.8 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EDP44164.1 - 0.7 7.9 5.6 0.93 7.5 5.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi ETC_C1_NDUFA4 PF04800.12 EDP44165.1 - 2.1e-14 53.5 0.3 3.2e-14 53.0 0.3 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region ATP_bind_1 PF03029.17 EDP44166.1 - 2.3e-36 125.8 0.0 2.9e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLZ PF16526.5 EDP44166.1 - 0.032 14.6 0.1 0.6 10.5 0.0 2.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels EHN PF06441.12 EDP44166.1 - 0.11 12.8 0.1 0.17 12.3 0.1 1.2 1 0 0 1 1 1 0 Epoxide hydrolase N terminus ATP_bind_1 PF03029.17 EDP44167.1 - 4.1e-06 26.8 0.1 4.4e-06 26.7 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein HTH_Tnp_Mu_2 PF09039.11 EDP44167.1 - 0.0046 17.0 0.0 0.0051 16.9 0.0 1.3 1 0 0 1 1 1 1 Mu DNA binding, I gamma subdomain HSA PF07529.13 EDP44169.1 - 2.3e-12 47.1 1.3 2.3e-12 47.1 1.3 4.5 4 1 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.6 EDP44169.1 - 0.011 15.9 0.6 0.027 14.7 0.6 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EDP44169.1 - 0.12 12.6 0.2 0.27 11.4 0.2 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain SpoIIE PF07228.12 EDP44170.1 - 9.7e-08 32.2 0.0 0.0069 16.3 0.0 2.9 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EDP44170.1 - 1.8e-07 31.1 0.0 0.0058 16.3 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EDP44170.1 - 7.3e-07 29.0 1.9 7.3e-07 29.0 1.9 1.8 2 1 0 2 2 2 1 Protein phosphatase 2C Isochorismatase PF00857.20 EDP44171.1 - 1.6e-17 64.3 2.0 5e-17 62.6 2.0 1.7 1 1 0 1 1 1 1 Isochorismatase family TRP_N PF14558.6 EDP44172.1 - 1.3e-24 87.1 0.0 2.3e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 ML-like domain TRP PF06011.12 EDP44172.1 - 1.5e-14 53.6 1.7 2.1e-14 53.1 1.7 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel KH_1 PF00013.29 EDP44173.1 - 6.1e-80 263.0 6.5 4.6e-13 48.8 0.0 11.3 11 1 0 11 11 11 9 KH domain KH_2 PF07650.17 EDP44173.1 - 2e-11 43.6 5.2 0.39 10.6 0.0 6.5 5 1 1 6 6 6 4 KH domain KH_4 PF13083.6 EDP44173.1 - 1.2e-05 25.1 6.6 2.1 8.3 0.0 5.8 6 0 0 6 6 6 3 KH domain KH_5 PF13184.6 EDP44173.1 - 0.00025 21.1 0.7 49 4.1 0.0 5.8 7 0 0 7 7 7 0 NusA-like KH domain ZT_dimer PF16916.5 EDP44173.1 - 0.057 13.5 1.3 0.73 10.0 0.2 3.3 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter SelP_N PF04592.14 EDP44173.1 - 3.2 7.1 6.5 5.7 6.3 6.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MFS_1 PF07690.16 EDP44174.1 - 1.2e-19 70.4 42.8 7.5e-11 41.6 23.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1435 PF07256.12 EDP44174.1 - 0.056 13.5 0.3 0.056 13.5 0.3 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1435) WD40 PF00400.32 EDP44175.1 - 3.2e-13 49.9 5.9 0.00048 20.9 0.0 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Hira PF07569.11 EDP44175.1 - 0.0049 16.6 0.0 0.16 11.6 0.0 2.4 1 1 0 1 1 1 1 TUP1-like enhancer of split Metallophos PF00149.28 EDP44176.1 - 6.2e-11 43.2 2.0 1e-10 42.5 2.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos PF00149.28 EDP44177.1 - 1.3e-10 42.1 2.6 3e-10 41.0 2.6 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF836 PF05768.14 EDP44179.1 - 4.4e-11 43.0 0.0 5.7e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) SUR7 PF06687.12 EDP44180.1 - 3.8e-07 29.9 2.6 1e-06 28.6 2.6 1.6 1 1 0 1 1 1 1 SUR7/PalI family Claudin_2 PF13903.6 EDP44180.1 - 0.00062 19.6 0.3 0.001 18.8 0.3 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction tRNA-synt_1 PF00133.22 EDP44181.1 - 2.6e-32 111.9 0.0 2.1e-23 82.5 0.0 3.2 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDP44181.1 - 1.3e-14 54.4 0.1 4.1e-14 52.8 0.1 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDP44181.1 - 4.6e-14 52.0 0.0 1.3e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDP44181.1 - 1.2e-06 28.1 0.0 2.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Med12 PF09497.10 EDP44182.1 - 6.4e-14 52.0 0.6 6.4e-14 52.0 0.6 2.8 3 0 0 3 3 3 1 Transcription mediator complex subunit Med12 SNF2_N PF00176.23 EDP44183.1 - 6.1e-58 196.2 0.0 9.2e-58 195.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EDP44183.1 - 8.7e-20 70.4 4.6 2.4e-14 52.9 0.1 3.8 3 1 1 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EDP44183.1 - 1.5e-18 67.2 0.0 3.7e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP44183.1 - 7.2e-08 32.6 0.0 5e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 EDP44183.1 - 0.00087 19.6 0.1 0.00087 19.6 0.1 4.0 4 1 0 4 4 4 1 Chromodomain helicase DNA-binding domain 1 DEAD PF00270.29 EDP44183.1 - 0.005 16.6 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4208 PF13907.6 EDP44184.1 - 3.2e-27 94.8 0.6 6.2e-27 93.9 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) RAP1 PF07218.11 EDP44184.1 - 1.9 6.7 4.9 2.3 6.4 4.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MMR_HSR1 PF01926.23 EDP44185.1 - 4.2e-15 55.8 0.2 1.2e-12 48.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP44185.1 - 2.3e-07 30.5 0.1 8.8e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EDP44185.1 - 1.8e-05 24.7 0.4 0.035 14.0 0.2 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDP44185.1 - 3.6e-05 23.4 0.1 0.0027 17.3 0.0 2.6 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDP44185.1 - 0.0061 16.6 0.9 0.55 10.3 0.2 3.0 2 1 1 3 3 3 1 Dynamin family PALP PF00291.25 EDP44186.1 - 8.7e-79 265.0 2.7 1.2e-78 264.5 2.7 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EDP44186.1 - 1e-38 131.0 0.0 8.2e-22 76.8 0.0 3.5 3 0 0 3 3 3 3 C-terminal regulatory domain of Threonine dehydratase NQRA_SLBB PF11973.8 EDP44186.1 - 0.071 13.8 0.0 26 5.6 0.0 3.1 3 0 0 3 3 3 0 NQRA C-terminal domain ABC_membrane PF00664.23 EDP44187.1 - 8.3e-93 311.0 20.4 1.4e-48 165.9 4.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDP44187.1 - 2.6e-59 199.7 0.0 1.4e-28 100.1 0.0 2.8 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDP44187.1 - 3.2e-10 39.8 4.8 0.00028 20.4 0.0 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP44187.1 - 9.9e-06 25.2 0.1 0.16 11.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EDP44187.1 - 8.5e-05 22.8 4.1 0.81 10.0 0.1 4.4 3 1 1 4 4 4 2 AAA domain AAA_30 PF13604.6 EDP44187.1 - 0.00036 20.3 0.5 0.036 13.8 0.1 3.3 3 1 0 3 3 3 1 AAA domain DUF87 PF01935.17 EDP44187.1 - 0.0011 19.1 0.2 1.2 9.1 0.0 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_33 PF13671.6 EDP44187.1 - 0.0031 17.7 3.3 1.1 9.4 0.0 3.8 4 0 0 4 4 4 1 AAA domain SbcCD_C PF13558.6 EDP44187.1 - 0.005 17.1 6.1 2.8 8.3 0.1 4.4 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EDP44187.1 - 0.0065 16.9 6.2 0.25 11.7 1.1 3.6 2 2 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.9 EDP44187.1 - 0.0065 15.3 0.3 0.083 11.7 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_18 PF13238.6 EDP44187.1 - 0.008 16.7 0.0 3.1 8.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain L_biotic_typeA PF04604.13 EDP44187.1 - 0.0089 15.9 0.3 5.5 6.9 0.1 2.7 2 0 0 2 2 2 1 Type-A lantibiotic RsgA_GTPase PF03193.16 EDP44187.1 - 0.015 15.2 0.0 6.1 6.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 EDP44187.1 - 0.016 14.8 1.4 3.4 7.2 0.0 4.1 4 1 0 4 4 4 0 AAA domain MeaB PF03308.16 EDP44187.1 - 0.028 13.4 0.0 0.14 11.1 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 EDP44187.1 - 0.068 12.3 0.0 7.6 5.6 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit Dala_Dala_lig_N PF01820.21 EDP44187.1 - 0.097 13.2 0.0 2.7 8.5 0.0 2.8 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus ATP_bind_1 PF03029.17 EDP44187.1 - 0.14 11.9 0.9 12 5.6 0.2 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 EDP44187.1 - 0.2 11.3 0.0 2.5 7.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AMP-binding PF00501.28 EDP44188.1 - 1.1e-70 238.4 0.0 1.8e-70 237.6 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EDP44188.1 - 2e-12 46.5 0.3 2.5e-11 42.9 0.2 2.5 2 1 0 2 2 2 1 Condensation domain PP-binding PF00550.25 EDP44188.1 - 6.9e-06 26.3 0.0 1.5e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding PF00501.28 EDP44189.1 - 1.8e-66 224.5 0.0 4.5e-66 223.2 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme PP-binding PF00550.25 EDP44189.1 - 0.00025 21.3 0.2 0.00076 19.8 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 EDP44190.1 - 1.5e-08 33.8 0.0 1.8e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Condensation domain Condensation PF00668.20 EDP44191.1 - 2.7e-51 174.7 0.0 4.5e-26 91.5 0.0 2.2 2 0 0 2 2 2 2 Condensation domain AMP-binding PF00501.28 EDP44191.1 - 4.3e-47 160.7 0.0 8.2e-47 159.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDP44191.1 - 4.3e-19 68.6 2.4 4.9e-09 36.4 0.1 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site DEAD PF00270.29 EDP44192.1 - 4.5e-41 140.5 0.0 9e-41 139.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP44192.1 - 8.5e-24 84.0 0.0 3e-23 82.3 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EDP44192.1 - 2.2e-17 63.0 0.1 7e-17 61.4 0.1 1.9 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 EDP44192.1 - 0.00017 21.6 0.0 0.00039 20.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDP44192.1 - 0.24 11.7 0.7 1.6 9.0 0.7 2.3 1 1 0 1 1 1 0 AAA domain PPR_2 PF13041.6 EDP44193.1 - 0.16 12.2 0.0 3.6 7.9 0.0 2.5 2 0 0 2 2 2 0 PPR repeat family Metallophos PF00149.28 EDP44194.1 - 3.5e-36 125.6 0.7 4.5e-36 125.3 0.7 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EDP44194.1 - 0.057 13.6 0.0 0.08 13.1 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Put_Phosphatase PF06888.12 EDP44195.1 - 1e-39 136.4 0.0 5.7e-27 94.6 0.0 2.0 1 1 1 2 2 2 2 Putative Phosphatase HAD PF12710.7 EDP44195.1 - 0.0078 16.6 0.2 2.5 8.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase RhoGEF PF00621.20 EDP44196.1 - 6.8e-17 62.3 0.0 1.1e-16 61.6 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain LysM PF01476.20 EDP44197.1 - 0.048 13.7 0.0 0.096 12.8 0.0 1.6 1 0 0 1 1 1 0 LysM domain DUF1168 PF06658.12 EDP44198.1 - 4.8e-31 107.4 8.7 4.8e-31 107.4 8.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) DUF4407 PF14362.6 EDP44198.1 - 0.6 9.4 4.1 0.84 8.9 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MmgE_PrpD PF03972.14 EDP44199.1 - 1.5e-154 514.8 0.4 1.7e-154 514.6 0.4 1.0 1 0 0 1 1 1 1 MmgE/PrpD family PALP PF00291.25 EDP44200.1 - 1.4e-66 224.9 0.2 1.7e-66 224.6 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Pkinase PF00069.25 EDP44201.1 - 2.5e-52 177.8 0.0 3.9e-52 177.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44201.1 - 4.7e-21 75.2 0.0 7.3e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP44201.1 - 0.0077 16.2 0.2 0.0077 16.2 0.2 3.2 2 1 0 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDP44201.1 - 0.024 14.2 0.3 0.048 13.3 0.3 1.4 1 0 0 1 1 1 0 RIO1 family SelP_N PF04592.14 EDP44201.1 - 2.4 7.5 10.1 4.9 6.5 10.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NUDE_C PF04880.13 EDP44202.1 - 2.7e-16 60.6 14.4 2.7e-16 60.6 14.4 3.7 2 2 0 3 3 2 1 NUDE protein, C-terminal conserved region ERM PF00769.19 EDP44202.1 - 2.5e-06 27.5 31.5 6.5e-05 22.9 17.0 2.1 1 1 1 2 2 2 2 Ezrin/radixin/moesin family ZapB PF06005.12 EDP44202.1 - 0.00019 21.8 25.4 0.035 14.5 5.7 4.6 3 1 1 4 4 4 2 Cell division protein ZapB TPR_MLP1_2 PF07926.12 EDP44202.1 - 0.003 17.6 7.5 0.003 17.6 7.5 3.9 2 1 2 4 4 4 1 TPR/MLP1/MLP2-like protein HALZ PF02183.18 EDP44202.1 - 0.032 14.5 11.5 1.3 9.3 3.9 3.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper Spectrin_like PF18373.1 EDP44202.1 - 0.088 12.9 0.9 0.36 10.9 0.9 2.1 1 0 0 1 1 1 0 Spectrin like domain ADIP PF11559.8 EDP44202.1 - 0.12 12.5 27.2 0.047 13.8 5.8 3.4 2 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 EDP44202.1 - 0.23 11.6 15.9 0.89 9.7 0.1 4.2 3 1 1 4 4 4 0 bZIP transcription factor YabA PF06156.13 EDP44202.1 - 0.43 11.2 25.4 1.6 9.4 5.8 4.2 2 1 2 4 4 4 0 Initiation control protein YabA FlaC_arch PF05377.11 EDP44202.1 - 0.49 10.8 11.6 0.75 10.2 0.1 4.1 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 EDP44202.1 - 0.56 9.6 30.5 0.54 9.7 11.2 2.7 2 1 1 3 3 3 0 Golgin subfamily A member 5 PRKG1_interact PF15898.5 EDP44202.1 - 0.86 10.5 30.5 5.2 8.0 16.6 3.8 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Uso1_p115_C PF04871.13 EDP44202.1 - 1.6 9.1 28.2 0.3 11.5 1.7 3.6 3 1 1 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region AKNA PF12443.8 EDP44202.1 - 1.6 9.4 12.6 1.1 10.0 0.2 4.1 4 1 0 4 4 3 0 AT-hook-containing transcription factor Peptidase_S46 PF10459.9 EDP44202.1 - 3 6.4 13.6 3.6 6.1 13.6 1.2 1 0 0 1 1 1 0 Peptidase S46 GAS PF13851.6 EDP44202.1 - 3.8 6.8 30.4 0.052 12.9 14.6 3.2 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding IFT57 PF10498.9 EDP44202.1 - 3.9 6.3 19.8 0.16 10.9 9.0 2.3 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Flg_hook PF02120.16 EDP44202.1 - 9.2 6.2 11.5 0.2 11.5 0.7 3.2 3 1 0 3 3 3 0 Flagellar hook-length control protein FliK CAP_GLY PF01302.25 EDP44203.1 - 2e-15 56.6 0.3 3e-15 56.0 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain GIT_CC PF16559.5 EDP44203.1 - 5.4 7.0 6.8 1.7 8.5 0.4 3.3 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor GN3L_Grn1 PF08701.11 EDP44204.1 - 5e-26 90.6 15.6 5e-26 90.6 15.6 3.2 5 0 0 5 5 5 1 GNL3L/Grn1 putative GTPase SDA1 PF05285.12 EDP44204.1 - 0.00013 21.5 23.3 0.00013 21.5 23.3 3.6 3 1 0 3 3 3 2 SDA1 Nop14 PF04147.12 EDP44204.1 - 0.0023 16.2 24.2 0.0023 16.2 24.2 3.1 3 0 0 3 3 3 1 Nop14-like family Cwf_Cwc_15 PF04889.12 EDP44204.1 - 0.0062 16.3 1.4 0.0062 16.3 1.4 4.1 3 1 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein YL1 PF05764.13 EDP44204.1 - 0.029 14.5 0.1 0.029 14.5 0.1 4.1 3 1 1 4 4 4 0 YL1 nuclear protein AAA_18 PF13238.6 EDP44204.1 - 0.62 10.6 0.0 0.62 10.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain Proteasome PF00227.26 EDP44205.1 - 3.9e-35 121.1 0.0 4.3e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit EF-hand_1 PF00036.32 EDP44206.1 - 4.5e-08 32.1 1.2 6.2e-08 31.6 1.2 1.3 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EDP44206.1 - 2e-05 23.8 0.6 3.4e-05 23.1 0.6 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EDP44206.1 - 3.6e-05 24.1 0.1 4.7e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EDP44206.1 - 0.00024 20.8 0.6 0.00036 20.2 0.5 1.5 1 1 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 EDP44206.1 - 0.00081 19.2 0.2 0.0011 18.8 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair Ribosomal_S13 PF00416.22 EDP44207.1 - 2.3e-19 70.0 0.0 1.6e-09 38.2 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S13/S18 FbpA PF05833.11 EDP44207.1 - 0.0002 20.3 0.0 0.0003 19.7 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Pkinase PF00069.25 EDP44208.1 - 5.9e-30 104.5 0.0 1.5e-26 93.3 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44208.1 - 6.8e-20 71.4 0.0 7e-19 68.1 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44208.1 - 6.2e-06 25.7 0.0 1.4e-05 24.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like AMP-binding PF00501.28 EDP44209.1 - 1.6e-49 168.6 0.1 6.6e-49 166.6 0.0 1.9 1 1 1 2 2 2 1 AMP-binding enzyme ACAS_N PF16177.5 EDP44209.1 - 5.1e-09 35.9 0.3 1.4e-08 34.5 0.3 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EDP44209.1 - 0.057 14.4 0.4 0.19 12.8 0.1 2.0 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Gar1 PF04410.14 EDP44210.1 - 9.2e-35 119.7 0.0 1.1e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Vps26 PF03643.15 EDP44211.1 - 6e-129 428.9 1.8 6.9e-129 428.7 1.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EDP44211.1 - 0.0043 17.1 0.1 0.16 12.0 0.0 2.9 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.12 EDP44211.1 - 0.0076 15.1 0.4 0.028 13.2 0.1 1.8 2 0 0 2 2 2 1 Bul1 N terminus ATG27 PF09451.10 EDP44212.1 - 5.5e-62 210.0 0.0 6.6e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 DUF1218 PF06749.12 EDP44212.1 - 0.065 13.8 4.2 0.17 12.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Man-6-P_recep PF02157.15 EDP44212.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate receptor Peptidase_M20 PF01546.28 EDP44213.1 - 1.8e-23 83.3 0.0 1.2e-22 80.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EDP44213.1 - 8.5e-13 48.6 10.4 0.0057 17.5 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat M20_dimer PF07687.14 EDP44213.1 - 9.7e-10 38.3 0.1 1.9e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 EDP44213.1 - 3.4e-05 24.1 0.0 0.15 12.4 0.0 4.5 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_Rpc34 PF05158.12 EDP44214.1 - 1.2e-65 222.1 0.0 2.1e-65 221.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit MarR PF01047.22 EDP44214.1 - 0.013 15.4 0.2 0.032 14.2 0.2 1.7 1 0 0 1 1 1 0 MarR family RPA_C PF08784.11 EDP44214.1 - 0.02 15.6 0.0 0.064 13.9 0.0 1.9 1 0 0 1 1 1 0 Replication protein A C terminal HxlR PF01638.17 EDP44214.1 - 0.033 14.0 0.1 0.068 13.0 0.1 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Rrf2 PF02082.20 EDP44214.1 - 0.17 12.3 0.2 0.55 10.6 0.1 1.9 2 0 0 2 2 2 0 Transcriptional regulator LAP1C PF05609.12 EDP44214.1 - 6.5 5.7 23.4 9.6 5.2 23.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Topoisom_I_N PF02919.15 EDP44215.1 - 1.8e-81 272.7 0.1 1.8e-81 272.7 0.1 3.0 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 EDP44215.1 - 6.4e-76 254.6 0.0 6.4e-76 254.6 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 EDP44215.1 - 1.2e-14 54.0 10.6 1.5e-13 50.4 0.3 3.2 3 0 0 3 3 3 2 C-terminal topoisomerase domain WHAMM-JMY_N PF15920.5 EDP44215.1 - 0.02 14.8 0.1 0.068 13.0 0.0 1.9 2 0 0 2 2 2 0 N-terminal of Junction-mediating and WASP homolog-associated CDC45 PF02724.14 EDP44215.1 - 4.4 5.5 29.3 0.021 13.2 9.0 2.3 2 0 0 2 2 2 0 CDC45-like protein NDUF_B12 PF08122.12 EDP44216.1 - 2.1e-18 66.1 1.6 2.2e-18 66.1 1.6 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Cytochrom_B559 PF00283.19 EDP44216.1 - 0.079 12.4 0.2 0.13 11.8 0.2 1.3 1 0 0 1 1 1 0 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits PAS PF00989.25 EDP44217.1 - 0.00096 19.1 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold FAM91_N PF14647.6 EDP44217.1 - 0.073 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 FAM91 N-terminus SelP_N PF04592.14 EDP44217.1 - 2.2 7.6 6.2 3.4 7.0 6.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PEPCK_ATP PF01293.20 EDP44218.1 - 2.5e-216 718.8 0.0 2.9e-216 718.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EDP44218.1 - 0.083 13.0 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_trans_NIPA PF05653.14 EDP44219.1 - 7.6e-90 301.0 28.2 1e-89 300.5 28.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDP44219.1 - 6.6e-05 23.1 6.2 6.6e-05 23.1 6.2 3.3 3 1 0 3 3 3 1 EamA-like transporter family TFIIA PF03153.13 EDP44219.1 - 0.1 12.6 4.6 0.15 12.0 4.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sde2_N_Ubi PF13019.6 EDP44219.1 - 0.15 11.8 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain CRPA PF05745.11 EDP44219.1 - 1.4 8.9 9.5 3.2 7.8 1.4 2.5 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Cwf_Cwc_15 PF04889.12 EDP44219.1 - 1.4 8.6 8.0 2.2 7.9 8.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 EDP44219.1 - 2.3 8.7 10.5 5 7.6 10.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain LRR_8 PF13855.6 EDP44220.1 - 4.2e-39 132.1 51.5 5e-07 29.4 0.9 9.0 6 2 3 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 EDP44220.1 - 9.7e-38 127.6 39.4 7e-06 26.3 0.6 11.6 4 1 8 14 14 14 14 Leucine Rich repeats (2 copies) PP2C PF00481.21 EDP44220.1 - 7.3e-37 127.4 0.0 1.2e-36 126.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Guanylate_cyc PF00211.20 EDP44220.1 - 1.6e-26 93.1 0.0 2.9e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 EDP44220.1 - 1.2e-09 37.9 17.2 0.0003 20.3 0.0 5.2 3 1 1 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 EDP44220.1 - 0.0007 19.8 35.1 8.3 7.4 0.0 13.6 15 1 0 15 15 15 1 Leucine Rich Repeat LRR_6 PF13516.6 EDP44220.1 - 0.027 14.5 30.7 16 5.8 0.0 11.3 12 0 0 12 12 12 0 Leucine Rich repeat RsmF_methylt_CI PF17126.5 EDP44220.1 - 0.15 12.2 0.1 47 4.1 0.0 3.6 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain Mito_carr PF00153.27 EDP44221.1 - 9e-27 92.8 2.4 6.1e-15 54.9 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein ATP-sulfurylase PF01747.17 EDP44222.1 - 1.1e-79 266.8 0.0 1.5e-79 266.4 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EDP44222.1 - 4.1e-56 189.2 0.0 6.5e-56 188.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EDP44222.1 - 8.8e-52 175.0 0.0 1.5e-51 174.2 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain TOBE_3 PF12857.7 EDP44222.1 - 0.076 12.9 0.1 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 TOBE-like domain CBFD_NFYB_HMF PF00808.23 EDP44223.1 - 4.1e-13 49.4 0.8 4.1e-13 49.4 0.8 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 EDP44223.1 - 0.036 14.3 0.1 0.062 13.5 0.1 1.3 1 0 0 1 1 1 0 CENP-W protein Histone PF00125.24 EDP44223.1 - 0.05 14.0 0.8 0.05 14.0 0.8 1.9 2 1 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DNA_pol3_alpha PF07733.12 EDP44223.1 - 0.14 11.7 1.4 0.22 11.1 1.4 1.2 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha NTPase domain Ku PF02735.16 EDP44224.1 - 1.4e-34 119.6 0.0 1.9e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EDP44224.1 - 5.2e-10 39.4 0.0 8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain adh_short_C2 PF13561.6 EDP44225.1 - 1.6e-45 155.5 0.6 1.9e-45 155.2 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDP44225.1 - 1.5e-37 128.9 0.1 1.9e-37 128.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EDP44225.1 - 8.8e-11 42.0 0.1 1.2e-10 41.6 0.1 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EDP44225.1 - 0.037 13.2 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Enoyl_reductase PF12241.8 EDP44225.1 - 0.066 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region Ribosomal_L39 PF00832.20 EDP44226.1 - 3.7e-21 74.5 10.8 4.3e-21 74.3 10.8 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Nmad3 PF18754.1 EDP44226.1 - 0.0094 15.6 0.6 0.0094 15.6 0.6 1.0 1 0 0 1 1 1 1 Nucleotide modification associated domain 3 NUDIX PF00293.28 EDP44227.1 - 1.8e-11 44.2 0.0 3e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 EDP44227.1 - 0.00032 20.6 0.0 0.00053 19.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NNMT_PNMT_TEMT PF01234.17 EDP44227.1 - 0.007 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family WD40 PF00400.32 EDP44228.1 - 3.1e-32 110.1 12.3 7.4e-06 26.6 0.0 9.8 11 0 0 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44228.1 - 2.2e-21 76.0 0.4 3.4e-08 33.7 0.0 6.4 4 4 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 EDP44228.1 - 1.4e-10 41.0 0.5 0.008 15.5 0.0 3.8 3 2 1 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EDP44228.1 - 1.9e-08 33.6 6.3 0.063 12.2 0.1 5.9 4 2 3 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Lactonase PF10282.9 EDP44228.1 - 8.1e-06 25.3 1.6 0.00019 20.8 0.3 3.0 3 0 0 3 3 3 1 Lactonase, 7-bladed beta-propeller RAB3GAP2_N PF14655.6 EDP44228.1 - 1.7e-05 24.3 0.0 0.75 9.0 0.0 3.8 4 0 0 4 4 4 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Frtz PF11768.8 EDP44228.1 - 0.0012 17.2 0.1 0.41 8.9 0.0 3.1 3 0 0 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz TFIIIC_delta PF12657.7 EDP44228.1 - 0.041 13.8 2.1 24 4.8 0.1 3.9 2 2 0 3 3 3 0 Transcription factor IIIC subunit delta N-term TPR_1 PF00515.28 EDP44229.1 - 3.4e-23 80.4 3.3 6.3e-06 25.8 0.0 5.8 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44229.1 - 2.8e-19 67.6 5.6 0.0007 19.5 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44229.1 - 5.7e-17 62.1 7.6 6e-07 30.0 1.8 4.7 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44229.1 - 1.8e-15 55.7 2.5 0.00027 20.9 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44229.1 - 3.5e-15 55.4 5.6 0.00049 19.7 0.0 4.9 3 2 2 5 5 4 4 TPR repeat TPR_14 PF13428.6 EDP44229.1 - 6.4e-13 48.4 4.0 0.02 15.7 0.4 6.1 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44229.1 - 6.6e-12 44.6 4.1 0.0086 16.0 0.1 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44229.1 - 3.3e-11 43.5 9.3 1.5e-06 28.6 2.7 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44229.1 - 5.9e-08 32.6 1.0 0.14 12.6 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44229.1 - 7.1e-08 32.6 10.2 0.0001 22.5 0.0 5.0 2 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EDP44229.1 - 4.4e-05 23.9 4.5 4 8.3 0.1 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 EDP44229.1 - 5.4e-05 23.5 16.4 0.017 15.5 3.3 5.3 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EDP44229.1 - 8.9e-05 22.6 3.5 1.1 9.5 0.1 4.5 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EDP44229.1 - 0.0016 18.2 11.8 0.022 14.6 0.3 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat BTAD PF03704.17 EDP44229.1 - 0.017 15.6 2.6 2.4 8.6 0.3 3.1 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 EDP44229.1 - 0.026 14.6 0.1 4.1 7.5 0.1 3.3 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF5344 PF17279.2 EDP44229.1 - 0.032 14.8 0.7 0.073 13.7 0.0 1.9 2 0 0 2 2 1 0 Family of unknown function (DUF5344) ChAPs PF09295.10 EDP44229.1 - 0.11 11.4 0.1 0.22 10.5 0.1 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) MAS20 PF02064.15 EDP44229.1 - 0.17 12.0 1.1 18 5.4 0.0 3.2 2 1 1 3 3 3 0 MAS20 protein import receptor ANAPC3 PF12895.7 EDP44229.1 - 0.24 11.7 7.9 5.1 7.4 0.2 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3684 PF12449.8 EDP44230.1 - 0 1103.0 0.0 0 1102.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) MethyTransf_Reg PF10119.9 EDP44230.1 - 0.072 13.8 0.2 12 6.7 0.1 3.2 2 0 0 2 2 2 0 Predicted methyltransferase regulatory domain CUE PF02845.16 EDP44230.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 CUE domain Diphthamide_syn PF01866.17 EDP44231.1 - 1.9e-84 283.7 0.0 1.2e-83 281.0 0.0 1.9 1 1 0 1 1 1 1 Putative diphthamide synthesis protein MRC1 PF09444.10 EDP44232.1 - 7.8e-32 110.8 24.7 7.8e-32 110.8 24.7 2.9 2 0 0 2 2 2 1 MRC1-like domain BLOC1S3 PF15753.5 EDP44232.1 - 8.7 6.4 11.4 4.8 7.3 5.7 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 CENP-F_leu_zip PF10473.9 EDP44233.1 - 0.0049 16.9 2.0 0.0049 16.9 2.0 3.8 2 2 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EDP44233.1 - 0.0083 16.2 25.2 0.024 14.7 3.5 4.6 3 2 1 4 4 4 2 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 EDP44233.1 - 0.098 13.1 4.5 16 5.9 0.0 3.7 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 EDP44233.1 - 0.33 10.2 25.9 0.061 12.6 3.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) ZapB PF06005.12 EDP44233.1 - 0.4 11.2 20.3 3 8.3 0.1 3.8 3 1 1 4 4 4 0 Cell division protein ZapB YabA PF06156.13 EDP44233.1 - 1.5 9.5 15.6 0.92 10.2 3.1 3.3 2 1 0 3 3 3 0 Initiation control protein YabA Nnf1 PF03980.14 EDP44233.1 - 1.6 9.1 18.2 0.22 11.9 1.4 3.7 3 1 0 3 3 3 0 Nnf1 Cep57_CLD_2 PF14197.6 EDP44233.1 - 1.9 8.6 23.7 0.17 12.0 3.8 4.0 2 2 1 3 3 3 0 Centrosome localisation domain of PPC89 APG6_N PF17675.1 EDP44233.1 - 3.3 8.3 31.8 1.1 9.8 6.2 3.3 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF1664 PF07889.12 EDP44233.1 - 4.2 7.4 13.3 8.5 6.4 1.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF2968 PF11180.8 EDP44233.1 - 5.1 6.7 23.0 0.71 9.5 5.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2968) YojJ PF10372.9 EDP44233.1 - 6.7 6.9 10.0 9.5 6.4 2.4 3.3 3 1 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus DUF2205 PF10224.9 EDP44233.1 - 9 6.4 12.9 0.76 9.8 0.2 4.0 3 2 0 3 3 3 0 Short coiled-coil protein tRNA-synt_1b PF00579.25 EDP44234.1 - 9.6e-64 215.5 0.0 1.3e-63 215.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 EDP44234.1 - 3.4e-06 26.7 0.0 7.6e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain TyrRSs_C PF16714.5 EDP44234.1 - 3.7e-05 23.5 0.2 0.0035 17.1 0.2 2.5 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain RCC1_2 PF13540.6 EDP44235.1 - 5.3e-08 32.5 6.9 1e-06 28.3 0.9 3.0 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EDP44235.1 - 6.2e-06 26.7 0.5 6.2e-06 26.7 0.5 3.4 3 1 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Tim17 PF02466.19 EDP44236.1 - 1.5e-30 105.9 4.7 2e-30 105.4 4.7 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family APG6 PF04111.12 EDP44237.1 - 5.7e-55 186.0 0.0 1.5e-54 184.6 0.0 1.6 2 0 0 2 2 2 1 Apg6 BARA domain APG6_N PF17675.1 EDP44237.1 - 8e-15 55.5 15.0 1.2e-14 55.0 15.0 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 EDP44237.1 - 0.0041 17.1 3.2 0.0041 17.1 3.2 2.1 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Transcrip_act PF04949.13 EDP44237.1 - 0.065 13.1 2.0 0.11 12.3 2.0 1.4 1 0 0 1 1 1 0 Transcriptional activator FliJ PF02050.16 EDP44237.1 - 0.83 9.9 11.2 0.37 11.0 8.0 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein Atg14 PF10186.9 EDP44237.1 - 2 7.4 6.9 3 6.8 6.9 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2312 PF10073.9 EDP44237.1 - 4.7 6.9 8.9 0.83 9.3 2.3 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) ATP-synt_DE_N PF02823.16 EDP44238.1 - 3.4e-16 58.9 0.1 5.1e-16 58.4 0.1 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ABC_membrane_2 PF06472.15 EDP44239.1 - 2.7e-85 286.0 7.4 3.6e-85 285.6 7.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDP44239.1 - 9e-18 65.1 2.3 1.3e-17 64.6 0.0 2.3 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EDP44239.1 - 0.0024 17.7 1.3 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP44239.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EDP44239.1 - 0.041 14.4 0.0 0.041 14.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain ODC_AZ PF02100.17 EDP44240.1 - 1.2e-10 41.4 0.0 1.8e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme SecY PF00344.20 EDP44241.1 - 4.8e-72 242.8 9.7 6e-72 242.5 9.7 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EDP44241.1 - 6.6e-17 61.1 0.3 1.8e-16 59.7 0.3 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p Claudin_3 PF06653.11 EDP44241.1 - 0.24 11.3 0.0 0.24 11.3 0.0 3.1 4 0 0 4 4 4 0 Tight junction protein, Claudin-like RNA_pol_N PF01194.17 EDP44242.1 - 2.3e-30 104.7 0.6 2.8e-30 104.4 0.6 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Transposase_31 PF04754.12 EDP44242.1 - 0.00029 20.5 0.0 0.00031 20.4 0.0 1.0 1 0 0 1 1 1 1 Putative transposase, YhgA-like Chordopox_RPO7 PF05864.12 EDP44242.1 - 0.044 14.0 0.2 0.057 13.7 0.2 1.2 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BRE1 PF08647.11 EDP44244.1 - 6.1e-24 83.9 9.7 6.1e-24 83.9 9.7 6.4 5 2 1 6 6 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EDP44244.1 - 5.8e-07 29.3 9.0 5.8e-07 29.3 9.0 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP44244.1 - 2.3e-06 27.4 11.4 6.3e-06 26.0 11.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP44244.1 - 5.3e-06 26.3 11.1 5.3e-06 26.3 11.1 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDP44244.1 - 7.1e-06 25.9 4.6 1.6e-05 24.8 4.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EDP44244.1 - 0.00013 21.7 9.7 0.00013 21.7 9.7 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDP44244.1 - 0.0014 18.5 6.7 0.0014 18.5 6.7 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDP44244.1 - 0.0019 18.5 9.3 0.0019 18.5 9.3 2.1 3 0 0 3 3 1 1 Ring finger domain zf-RING_6 PF14835.6 EDP44244.1 - 0.0022 17.8 3.3 0.0047 16.8 3.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ribbon_3 PF13248.6 EDP44244.1 - 0.004 16.5 4.3 0.03 13.7 0.5 3.2 3 0 0 3 3 3 1 zinc-ribbon domain PKcGMP_CC PF16808.5 EDP44244.1 - 0.02 14.7 6.6 1.6 8.6 0.4 3.9 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF983 PF06170.12 EDP44244.1 - 0.22 12.0 3.1 29 5.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF983) zf-C3HC4_4 PF15227.6 EDP44244.1 - 0.43 10.8 10.6 0.16 12.2 6.8 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Halo_GVPC PF05465.13 EDP44244.1 - 2.2 8.6 11.9 7.3 7.0 0.2 4.9 4 0 0 4 4 4 0 Halobacterial gas vesicle protein C (GVPC) repeat zf-rbx1 PF12678.7 EDP44244.1 - 3.7 7.9 11.0 0.38 11.1 6.0 2.0 2 0 0 2 2 1 0 RING-H2 zinc finger domain Bap31_Bap29_C PF18035.1 EDP44244.1 - 5.4 7.1 13.6 1.5 8.9 0.6 4.7 4 0 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain TMF_DNA_bd PF12329.8 EDP44244.1 - 8 6.5 25.2 1.1 9.3 4.2 5.6 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding Pyridoxal_deC PF00282.19 EDP44245.1 - 7.4e-10 38.1 0.0 1.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Pyridoxal_deC PF00282.19 EDP44246.1 - 1.2e-05 24.2 0.0 1.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain TFIIA PF03153.13 EDP44247.1 - 7.6e-48 164.5 18.9 1.1e-27 98.2 15.2 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 EDP44247.1 - 0.15 11.8 9.1 0.18 11.5 9.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 EDP44247.1 - 1.1 7.3 8.4 1.4 6.9 8.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi PWWP PF00855.17 EDP44248.1 - 1e-18 67.5 1.6 2e-18 66.6 0.0 2.4 2 1 0 2 2 2 1 PWWP domain Med26 PF08711.11 EDP44248.1 - 3.2e-08 33.5 0.0 8.4e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain BSP_II PF05432.11 EDP44248.1 - 0.019 14.7 34.0 0.026 14.2 34.0 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Drc1-Sld2 PF11719.8 EDP44248.1 - 0.18 11.3 28.5 0.27 10.8 28.5 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein Hid1 PF12722.7 EDP44248.1 - 0.4 8.7 20.4 0.55 8.3 20.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peptidase_S64 PF08192.11 EDP44248.1 - 1.2 7.6 12.2 1.4 7.3 12.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 TACC_C PF05010.14 EDP44249.1 - 0.0037 17.1 4.5 0.0037 17.1 4.5 2.5 1 1 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 EDP44249.1 - 2.2 8.3 8.0 6.2 6.9 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Hamartin PF04388.12 EDP44249.1 - 2.3 6.8 32.0 0.79 8.3 19.8 3.2 2 1 0 2 2 2 0 Hamartin protein KLRAQ PF10205.9 EDP44249.1 - 2.5 8.4 11.9 0.1 12.8 3.5 2.8 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein TMF_TATA_bd PF12325.8 EDP44249.1 - 2.8 8.2 27.8 0.31 11.3 7.9 3.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Allexi_40kDa PF05549.11 EDP44249.1 - 4.4 6.7 13.7 1.6 8.1 3.3 3.1 1 1 1 3 3 3 0 Allexivirus 40kDa protein Tropomyosin_1 PF12718.7 EDP44249.1 - 9.2 6.4 24.3 0.4 10.8 2.3 3.3 2 1 1 3 3 3 0 Tropomyosin like DUF2057 PF09829.9 EDP44249.1 - 9.5 6.3 8.8 1.6 8.9 4.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) tRNA-synt_1c PF00749.21 EDP44250.1 - 1.8e-107 358.9 0.0 3.5e-107 357.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 EDP44250.1 - 6.7e-42 143.2 1.0 8.6e-42 142.9 0.0 1.7 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 EDP44250.1 - 5.3e-31 107.8 0.0 6.5e-30 104.3 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 EDP44250.1 - 6.1e-08 33.5 0.6 6.1e-08 33.5 0.6 2.1 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 EMP70 PF02990.16 EDP44251.1 - 1.6e-190 634.2 0.3 2.3e-190 633.7 0.3 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Sybindin PF04099.12 EDP44252.1 - 4.9e-08 33.0 0.0 9.5e-08 32.1 0.0 1.4 1 1 0 1 1 1 1 Sybindin-like family Sporozoite_P67 PF05642.11 EDP44252.1 - 0.14 10.3 0.3 0.21 9.6 0.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MDD_C PF18376.1 EDP44253.1 - 1e-71 240.6 0.0 1.3e-71 240.2 0.0 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EDP44253.1 - 2.4e-07 30.9 4.6 5.2e-07 29.8 4.6 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain Bac_luciferase PF00296.20 EDP44253.1 - 0.053 12.9 0.0 0.084 12.3 0.0 1.3 1 0 0 1 1 1 0 Luciferase-like monooxygenase DUF1819 PF08849.11 EDP44253.1 - 0.18 11.6 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative inner membrane protein (DUF1819) Ribosomal_L27e PF01777.18 EDP44254.1 - 2.9e-38 130.1 4.2 3.9e-38 129.7 4.2 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EDP44254.1 - 0.002 18.0 2.5 0.0035 17.3 2.5 1.4 1 0 0 1 1 1 1 KOW motif IQCJ-SCHIP1 PF15157.6 EDP44254.1 - 0.049 13.5 0.1 0.1 12.5 0.1 1.5 1 1 1 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Ribosom_S12_S23 PF00164.25 EDP44255.1 - 1.1e-47 160.3 0.6 1.4e-47 160.0 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 CBP4 PF07960.11 EDP44256.1 - 9.8e-11 41.6 0.0 1.4e-10 41.1 0.0 1.2 1 1 0 1 1 1 1 CBP4 DUF3886 PF13025.6 EDP44256.1 - 0.023 14.9 2.1 0.03 14.5 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Brix PF04427.18 EDP44257.1 - 6e-38 130.9 0.0 7.6e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Brix domain Erg28 PF03694.13 EDP44258.1 - 7.8e-31 106.7 1.4 9.2e-31 106.5 1.4 1.1 1 0 0 1 1 1 1 Erg28 like protein GST_N_2 PF13409.6 EDP44259.1 - 1.2e-15 57.5 0.0 3e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDP44259.1 - 9.5e-13 48.0 0.0 6.5e-12 45.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP44259.1 - 7.9e-06 26.0 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDP44259.1 - 0.00058 20.0 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EDP44259.1 - 0.038 14.4 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EDP44259.1 - 0.074 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RQC PF09382.10 EDP44259.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 RQC domain POT1PC PF16686.5 EDP44260.1 - 1.2e-14 54.5 0.0 4.5e-13 49.4 0.0 2.6 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EDP44260.1 - 0.0019 18.0 0.0 0.0052 16.6 0.0 1.7 1 1 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 DUF4050 PF13259.6 EDP44260.1 - 0.051 13.9 0.4 0.092 13.1 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) YL1 PF05764.13 EDP44261.1 - 0.015 15.5 4.2 0.022 14.9 4.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein NDUFB11 PF17250.2 EDP44261.1 - 0.076 13.6 0.1 0.18 12.4 0.1 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit WSD PF15613.6 EDP44261.1 - 1.3 9.6 3.5 6.9 7.2 0.1 3.2 3 1 0 3 3 3 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif FAM176 PF14851.6 EDP44261.1 - 6.3 6.5 6.9 2.5 7.8 2.5 2.0 2 0 0 2 2 2 0 FAM176 family tRNA-synt_2 PF00152.20 EDP44262.1 - 2.7e-76 256.7 0.0 3.3e-76 256.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDP44262.1 - 8.8e-11 41.6 0.0 2.6e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EDP44262.1 - 3e-08 33.4 0.1 0.00013 21.5 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) SNase PF00565.17 EDP44263.1 - 5.7e-17 62.2 0.0 1.4e-16 60.9 0.0 1.7 1 1 0 1 1 1 1 Staphylococcal nuclease homologue LRR_8 PF13855.6 EDP44263.1 - 3.7e-12 45.8 8.0 3.6e-08 33.0 3.0 2.8 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EDP44263.1 - 1.1e-08 35.2 7.8 0.00073 19.9 2.1 4.1 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EDP44263.1 - 8.1e-05 22.4 7.8 5.3 7.4 0.5 4.7 4 0 0 4 4 4 3 Leucine Rich repeat zf-C3HC4_3 PF13920.6 EDP44264.1 - 1.5e-07 31.2 4.5 2.1e-07 30.7 4.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDP44264.1 - 4.4e-06 26.6 8.1 7.6e-06 25.9 8.1 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EDP44264.1 - 7.4e-06 25.8 7.9 1.1e-05 25.3 7.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EDP44264.1 - 2.6e-05 24.0 8.3 3.9e-05 23.4 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP44264.1 - 3.8e-05 23.9 6.8 5.5e-05 23.4 6.8 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EDP44264.1 - 0.0005 19.9 8.7 0.00078 19.3 8.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP44264.1 - 0.00052 20.1 7.3 0.00094 19.3 7.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EDP44264.1 - 0.00061 19.9 1.7 0.00087 19.4 1.7 1.2 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 EDP44264.1 - 0.0035 17.2 5.4 0.0062 16.4 5.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EDP44264.1 - 0.028 14.2 1.5 0.045 13.6 1.5 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RanBP PF00641.18 EDP44264.1 - 0.32 10.3 3.5 1.4 8.3 3.8 2.0 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others C1_2 PF03107.16 EDP44264.1 - 0.52 10.7 5.8 1.2 9.6 1.2 2.2 1 1 1 2 2 2 0 C1 domain FYVE PF01363.21 EDP44264.1 - 0.8 9.9 5.8 2 8.6 5.4 1.9 1 1 0 1 1 1 0 FYVE zinc finger GATase_5 PF13507.6 EDP44265.1 - 2.2e-97 325.2 0.0 3.4e-97 324.6 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EDP44265.1 - 3e-38 131.4 0.3 1.3e-27 96.8 0.0 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EDP44265.1 - 4.5e-28 97.5 0.0 8.4e-28 96.7 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EDP44265.1 - 1.1e-20 73.9 0.0 2.9e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain SWIRM PF04433.17 EDP44266.1 - 0.069 13.5 0.1 0.21 12.0 0.1 1.8 1 0 0 1 1 1 0 SWIRM domain zf-CCCH PF00642.24 EDP44267.1 - 7.8e-13 48.0 14.6 8.9e-07 28.7 4.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EDP44267.1 - 0.00025 21.0 9.6 0.016 15.3 2.9 2.7 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EDP44267.1 - 0.002 18.8 1.7 0.11 13.2 0.2 2.6 2 0 0 2 2 2 1 Torus domain zf-CCCH_3 PF15663.5 EDP44267.1 - 0.0023 18.1 5.1 0.027 14.7 0.5 2.3 2 0 0 2 2 2 2 Zinc-finger containing family RRM_1 PF00076.22 EDP44267.1 - 0.0077 16.0 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 EDP44268.1 - 1.4e-10 41.0 0.1 1.8e-10 40.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Gp-FAR-1 PF05823.12 EDP44268.1 - 0.052 13.9 0.1 0.061 13.7 0.1 1.1 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DHHC PF01529.20 EDP44269.1 - 4e-32 111.1 2.1 6.9e-32 110.4 2.1 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase FYVE PF01363.21 EDP44269.1 - 0.055 13.6 4.2 0.31 11.2 2.3 2.3 2 0 0 2 2 2 0 FYVE zinc finger zf-SNAP50_C PF12251.8 EDP44270.1 - 1.1e-08 35.1 0.5 6.5e-08 32.5 0.0 2.4 2 1 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal PI3_PI4_kinase PF00454.27 EDP44271.1 - 3.6e-14 53.2 0.0 5.7e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase RNA_pol_I_TF PF04090.12 EDP44272.1 - 1.9e-11 43.8 3.1 1.4e-09 37.7 0.2 3.0 1 1 2 3 3 3 2 RNA polymerase I specific initiation factor PP2C PF00481.21 EDP44273.1 - 3.4e-69 233.3 0.3 4e-69 233.1 0.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C UCR_Fe-S_N PF10399.9 EDP44273.1 - 0.15 11.5 0.1 0.29 10.5 0.1 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal ATP11 PF06644.11 EDP44274.1 - 8.9e-80 268.4 1.0 1.3e-79 267.8 1.0 1.3 1 0 0 1 1 1 1 ATP11 protein DUF3280 PF11684.8 EDP44274.1 - 0.03 14.8 1.5 0.054 13.9 1.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2380) GWT1 PF06423.12 EDP44275.1 - 4.4e-27 95.0 1.1 2.1e-26 92.8 0.0 2.7 3 0 0 3 3 3 1 GWT1 PTPS_related PF10131.9 EDP44275.1 - 0.01 14.2 1.2 0.022 13.1 1.2 1.5 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein OSCP PF00213.18 EDP44276.1 - 5.1e-35 121.1 0.7 6e-35 120.9 0.7 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit eIF-3c_N PF05470.12 EDP44277.1 - 4.3e-174 580.1 6.9 4.3e-174 580.1 6.9 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EDP44277.1 - 3e-15 56.6 0.1 3.1e-14 53.3 0.0 2.9 2 0 0 2 2 2 1 PCI domain PLN_propep PF16485.5 EDP44277.1 - 0.068 12.9 0.2 5.1 6.9 0.0 2.9 2 0 0 2 2 2 0 Protealysin propeptide CDC45 PF02724.14 EDP44277.1 - 0.5 8.6 19.7 1.1 7.5 19.7 1.5 1 0 0 1 1 1 0 CDC45-like protein Rrn6 PF10214.9 EDP44277.1 - 0.88 8.0 14.7 0.64 8.4 11.6 1.9 1 1 1 2 2 2 0 RNA polymerase I-specific transcription-initiation factor NOA36 PF06524.12 EDP44277.1 - 3.9 6.7 21.6 6.9 5.9 21.6 1.4 1 0 0 1 1 1 0 NOA36 protein Dfp1_Him1_M PF08630.10 EDP44278.1 - 1.3e-32 112.7 0.0 3.3e-32 111.4 0.0 1.7 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 EDP44278.1 - 2.2e-17 62.9 2.4 4.6e-17 61.9 2.4 1.6 1 0 0 1 1 1 1 DBF zinc finger PTCB-BRCT PF12738.7 EDP44278.1 - 3.9e-05 23.5 0.0 9.1e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EDP44278.1 - 0.0014 19.0 0.0 0.0036 17.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDP44278.1 - 0.069 13.6 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain RNase_H PF00075.24 EDP44279.1 - 2.8e-37 128.1 0.0 4.3e-37 127.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EDP44279.1 - 8.4e-18 64.4 0.4 1.6e-17 63.5 0.4 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.6 EDP44279.1 - 0.053 13.3 0.0 0.57 10.0 0.0 2.5 1 1 0 1 1 1 0 Reverse transcriptase-like RHH_6 PF16762.5 EDP44279.1 - 0.11 13.1 0.1 2 9.1 0.1 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF2325 PF10087.9 EDP44279.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) DUF1323 PF07037.11 EDP44279.1 - 0.68 10.3 2.5 1.9 8.9 2.5 1.8 1 1 0 1 1 1 0 Putative transcription regulator (DUF1323) FAD_binding_1 PF00667.20 EDP44280.1 - 9.2e-54 182.3 0.0 1.8e-53 181.4 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EDP44280.1 - 3.2e-29 102.0 0.0 6.5e-29 101.0 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EDP44280.1 - 6.6e-18 65.4 0.0 1.7e-17 64.0 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Rad10 PF03834.14 EDP44281.1 - 4e-47 159.0 0.8 4.4e-46 155.6 0.3 2.0 2 0 0 2 2 2 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EDP44281.1 - 3.7e-05 24.2 0.0 6.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EDP44281.1 - 0.089 12.9 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif UIM PF02809.20 EDP44281.1 - 0.28 11.2 4.6 0.54 10.3 4.6 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif Ribosomal_S8e PF01201.22 EDP44282.1 - 6.5e-47 159.1 0.4 1e-46 158.5 0.4 1.3 1 1 0 1 1 1 1 Ribosomal protein S8e Macoilin PF09726.9 EDP44282.1 - 3.5 6.1 8.8 4.7 5.7 8.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF3340 PF11818.8 EDP44282.1 - 5.6 7.1 11.2 8.7 6.5 11.2 1.3 1 1 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) Yip1 PF04893.17 EDP44283.1 - 5.5e-12 45.7 8.7 7.7e-12 45.3 8.7 1.2 1 0 0 1 1 1 1 Yip1 domain Mlh1_C PF16413.5 EDP44284.1 - 3.8e-62 210.1 0.0 6.5e-62 209.3 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EDP44284.1 - 1.4e-31 108.6 0.0 3.9e-31 107.2 0.0 1.7 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain EF_assoc_1 PF08355.12 EDP44284.1 - 0.12 12.0 0.0 0.82 9.3 0.0 2.3 2 0 0 2 2 2 0 EF hand associated DUF5538 PF17692.1 EDP44285.1 - 8.1e-05 22.7 7.1 0.42 10.7 0.2 4.1 1 1 2 4 4 4 3 Family of unknown function (DUF5538) GP46 PF07409.12 EDP44285.1 - 0.0034 17.1 5.9 21 4.9 0.1 4.3 1 1 3 4 4 4 3 Phage protein GP46 OxoDH_E1alpha_N PF12573.8 EDP44285.1 - 0.01 15.6 4.1 27 4.6 0.1 4.1 4 0 0 4 4 4 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal Phage_fiber_C PF06820.12 EDP44285.1 - 0.01 16.1 3.2 75 3.8 0.0 4.7 1 1 4 5 5 5 0 Putative prophage tail fibre C-terminus Lipoprotein_15 PF03640.15 EDP44285.1 - 0.011 15.2 4.5 87 2.8 0.0 5.0 5 0 0 5 5 5 0 Secreted repeat of unknown function U62_UL91 PF17442.2 EDP44285.1 - 0.18 11.8 0.0 3e+02 1.5 0.0 3.7 4 0 0 4 4 4 0 Functional domain of U62 and UL91 proteins RNase_PH PF01138.21 EDP44286.1 - 7.2e-12 46.0 0.0 1.6e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDP44286.1 - 5.9e-06 26.2 0.0 2.1e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 PTPA PF03095.15 EDP44288.1 - 8.5e-117 389.9 0.0 1e-116 389.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pro_sub2 PF18513.1 EDP44288.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Prodomain subtilisin 2 WD40 PF00400.32 EDP44289.1 - 6.8e-12 45.7 11.6 0.15 12.9 0.1 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat RabGAP-TBC PF00566.18 EDP44290.1 - 7.8e-40 136.8 0.0 1.2e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SH3_9 PF14604.6 EDP44290.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain Pkinase PF00069.25 EDP44291.1 - 6.4e-55 186.3 0.0 1.2e-54 185.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44291.1 - 1.1e-32 113.4 0.0 3.7e-32 111.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44291.1 - 0.00066 19.1 0.0 0.002 17.5 0.0 1.8 1 1 1 2 2 2 1 Kinase-like FAA_hydro_N_2 PF18288.1 EDP44291.1 - 0.009 16.4 2.2 0.033 14.6 2.2 2.0 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal domain 2 APH PF01636.23 EDP44291.1 - 0.025 14.5 5.8 0.25 11.2 0.1 3.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family PB1 PF00564.24 EDP44292.1 - 0.073 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 PB1 domain SPC22 PF04573.12 EDP44294.1 - 4.6e-34 117.4 0.1 5.3e-34 117.2 0.1 1.0 1 0 0 1 1 1 1 Signal peptidase subunit CI-B14_5a PF07347.12 EDP44295.1 - 0.00045 20.0 0.9 0.00096 19.0 0.1 1.8 2 0 0 2 2 2 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Auts2 PF15336.6 EDP44295.1 - 0.016 15.4 0.9 0.017 15.3 0.9 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein Oxysterol_BP PF01237.18 EDP44296.1 - 5.8e-135 449.9 0.0 1.2e-134 448.9 0.0 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 EDP44296.1 - 2.7e-13 50.3 0.1 6e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 PH domain Ank_5 PF13857.6 EDP44296.1 - 2.1e-11 43.8 0.2 5.1e-05 23.5 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP44296.1 - 5.7e-10 38.6 0.3 0.025 15.1 0.0 4.2 4 0 0 4 4 3 2 Ankyrin repeat Ank_2 PF12796.7 EDP44296.1 - 6.6e-08 33.0 0.1 7.9e-05 23.2 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP44296.1 - 5.3e-07 30.1 0.1 0.014 15.9 0.0 3.6 2 1 0 3 3 3 2 Ankyrin repeats (many copies) PH_8 PF15409.6 EDP44296.1 - 1.5e-06 28.4 0.1 3.3e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Ank PF00023.30 EDP44296.1 - 1.2e-05 25.5 0.4 0.028 14.9 0.1 3.7 3 0 0 3 3 3 1 Ankyrin repeat PH_11 PF15413.6 EDP44296.1 - 0.0003 21.2 0.1 0.0015 18.9 0.1 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain LapD_MoxY_N PF16448.5 EDP44296.1 - 0.064 13.1 0.2 0.17 11.7 0.2 1.7 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain Zein-binding PF04576.15 EDP44296.1 - 0.17 12.2 6.0 0.11 12.8 0.8 2.9 2 0 0 2 2 2 0 Zein-binding Fib_alpha PF08702.10 EDP44296.1 - 1 9.5 4.5 23 5.2 2.8 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Duo1 PF08651.10 EDP44297.1 - 3.9e-15 55.4 2.0 4e-15 55.3 0.8 1.7 2 0 0 2 2 2 1 DASH complex subunit Duo1 NINJA_B PF16136.5 EDP44297.1 - 0.018 15.4 1.2 0.018 15.4 1.2 1.9 2 0 0 2 2 2 0 Putative nuclear localisation signal DUF5344 PF17279.2 EDP44297.1 - 0.028 15.0 1.5 0.067 13.8 1.5 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5344) FTO_CTD PF12934.7 EDP44297.1 - 0.046 13.5 1.2 0.093 12.5 0.8 1.6 1 1 1 2 2 2 0 FTO C-terminal domain zf-C4H2 PF10146.9 EDP44297.1 - 0.12 12.7 0.1 0.16 12.3 0.1 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Retrotrans_gag PF03732.17 EDP44297.1 - 0.2 12.0 1.7 0.45 10.8 1.5 1.7 1 1 0 1 1 1 0 Retrotransposon gag protein ABA_GPCR PF12430.8 EDP44298.1 - 3.1e-37 128.1 10.0 3.1e-37 128.1 10.0 1.6 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EDP44298.1 - 6.5e-17 61.4 0.4 6.5e-17 61.4 0.4 2.2 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal Adaptin_N PF01602.20 EDP44299.1 - 0.26 9.8 2.6 0.16 10.5 0.7 1.5 2 0 0 2 2 2 0 Adaptin N terminal region FSH1 PF03959.13 EDP44300.1 - 8.2e-58 195.5 0.0 1e-57 195.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 EDP44300.1 - 4.2e-05 23.6 0.0 0.22 11.4 0.0 2.4 3 0 0 3 3 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EDP44300.1 - 5.9e-05 23.0 0.1 0.0019 18.1 0.1 2.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 EDP44300.1 - 0.00013 21.6 0.0 0.091 12.3 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EDP44300.1 - 0.0061 15.9 0.0 0.045 13.0 0.0 2.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP44300.1 - 0.0093 15.6 0.7 1.6 8.3 0.0 3.0 2 1 1 4 4 4 1 alpha/beta hydrolase fold ubiquitin PF00240.23 EDP44301.1 - 1e-22 79.6 0.0 1.7e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EDP44301.1 - 9.2e-20 70.2 0.7 2e-10 40.3 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 EDP44301.1 - 3.1e-14 52.4 2.4 3.1e-14 52.4 2.4 1.6 2 0 0 2 2 2 1 XPC-binding domain Rad60-SLD PF11976.8 EDP44301.1 - 6.3e-08 32.3 0.1 1.1e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EDP44301.1 - 0.0053 16.8 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDP44301.1 - 0.038 14.4 0.0 0.087 13.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain TetR_C_28 PF17937.1 EDP44301.1 - 0.047 14.1 0.5 0.095 13.2 0.5 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain CSTF2_hinge PF14327.6 EDP44301.1 - 0.066 13.7 1.6 0.21 12.1 1.6 1.8 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 DUF2407 PF10302.9 EDP44301.1 - 0.11 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain CASP_C PF08172.12 EDP44302.1 - 3.5e-33 115.0 2.7 3.5e-33 115.0 2.7 4.8 3 3 2 5 5 5 2 CASP C terminal SlyX PF04102.12 EDP44302.1 - 0.0039 17.8 0.4 0.0039 17.8 0.4 7.8 4 2 5 9 9 9 3 SlyX HMMR_N PF15905.5 EDP44302.1 - 0.0045 16.5 46.6 0.069 12.6 5.5 3.4 1 1 2 3 3 3 3 Hyaluronan mediated motility receptor N-terminal ArsR PF09824.9 EDP44302.1 - 0.044 13.4 0.5 1.4 8.5 0.0 3.0 3 0 0 3 3 3 0 ArsR transcriptional regulator CENP-H PF05837.12 EDP44302.1 - 0.16 12.4 0.1 0.16 12.4 0.1 6.1 3 1 2 6 6 6 0 Centromere protein H (CENP-H) WD40_alt PF14077.6 EDP44302.1 - 0.18 11.7 2.0 1.7e+02 2.2 0.0 4.4 3 1 1 4 4 4 0 Alternative WD40 repeat motif PspA_IM30 PF04012.12 EDP44302.1 - 0.54 9.8 75.3 0.063 12.9 46.0 4.2 1 1 4 5 5 5 0 PspA/IM30 family DUF3837 PF12939.7 EDP44302.1 - 1.7 9.1 0.0 1.7 9.1 0.0 3.5 5 0 0 5 5 5 0 Domain of unknown function (DUF3837) DUF5595 PF18077.1 EDP44302.1 - 2.2 8.4 12.9 0.92 9.6 0.3 4.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5595) CPSase_sm_chain PF00988.22 EDP44303.1 - 5e-44 149.2 0.0 7.3e-44 148.7 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EDP44303.1 - 1e-35 123.2 0.0 1.3e-35 122.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EDP44303.1 - 1.8e-06 27.9 0.0 4.6e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 zf-met PF12874.7 EDP44304.1 - 1.7e-06 28.2 0.7 3.7e-06 27.2 0.7 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EDP44304.1 - 5.2e-05 23.4 0.2 0.0001 22.5 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding Spem1 PF15670.5 EDP44304.1 - 1.1 8.8 5.5 0.43 10.1 3.3 1.5 2 0 0 2 2 2 0 Spermatid maturation protein 1 Rrn6 PF10214.9 EDP44304.1 - 2.6 6.4 6.4 3.5 6.0 6.4 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SusD_RagB PF07980.11 EDP44304.1 - 2.9 7.4 7.0 4.8 6.7 7.0 1.3 1 0 0 1 1 1 0 SusD family tRNA-synt_1 PF00133.22 EDP44305.1 - 1.8e-226 753.1 0.0 2.2e-226 752.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EDP44305.1 - 1e-23 83.9 0.0 2.5e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EDP44305.1 - 3.1e-14 52.5 0.3 0.0001 21.2 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EDP44305.1 - 9.4e-05 21.9 0.0 0.006 16.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain ATP-synt PF00231.19 EDP44306.1 - 1.8e-76 257.5 1.0 2e-76 257.4 1.0 1.0 1 0 0 1 1 1 1 ATP synthase RNA_Me_trans PF04252.13 EDP44306.1 - 0.12 11.9 0.0 7.4 6.1 0.0 2.6 2 1 0 2 2 2 0 Predicted SAM-dependent RNA methyltransferase eIF-5_eIF-2B PF01873.17 EDP44307.1 - 2.9e-41 140.0 0.3 5e-41 139.2 0.3 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 EDP44307.1 - 0.0019 17.6 0.1 0.0035 16.8 0.1 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Arc_trans_TRASH PF08394.10 EDP44307.1 - 0.54 10.6 6.1 0.77 10.1 0.1 2.5 1 1 1 2 2 2 0 Archaeal TRASH domain Tho1_MOS11_C PF18592.1 EDP44309.1 - 3.6e-12 45.9 0.8 6.6e-12 45.1 0.8 1.5 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 EDP44309.1 - 2.7e-10 39.7 0.3 2.7e-10 39.7 0.3 2.2 2 0 0 2 2 2 1 SAP domain FANC_SAP PF18081.1 EDP44309.1 - 0.011 15.9 6.0 0.5 10.6 0.8 2.4 2 0 0 2 2 2 0 Fanconi anemia-associated nuclease SAP domain Tmemb_cc2 PF10267.9 EDP44309.1 - 0.022 13.9 1.0 0.026 13.7 1.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CCT_2 PF09425.10 EDP44309.1 - 0.1 12.5 0.1 0.21 11.5 0.1 1.6 1 0 0 1 1 1 0 Divergent CCT motif DUF737 PF05300.11 EDP44309.1 - 0.13 12.6 3.8 0.18 12.2 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Apt1 PF10351.9 EDP44309.1 - 0.34 9.7 2.7 0.51 9.1 2.7 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain ArfGap PF01412.18 EDP44311.1 - 7e-41 139.0 1.6 1.4e-40 138.0 1.6 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SNF2_N PF00176.23 EDP44312.1 - 1.1e-60 205.3 0.1 1.6e-60 204.7 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP44312.1 - 4.2e-16 59.3 0.1 1.3e-13 51.2 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 EDP44312.1 - 9.5e-11 42.0 0.0 2.7e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EDP44312.1 - 0.00071 18.9 0.2 0.0019 17.5 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_34 PF13872.6 EDP44312.1 - 0.003 16.5 0.0 0.0056 15.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 PPTA PF01239.22 EDP44313.1 - 2.5e-12 46.1 1.9 2.6e-07 30.2 0.0 2.3 2 0 0 2 2 2 2 Protein prenyltransferase alpha subunit repeat DUF211 PF02680.14 EDP44313.1 - 0.24 11.6 0.0 0.29 11.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 Yae1_N PF09811.9 EDP44314.1 - 2.8e-08 33.3 1.6 4.3e-08 32.7 1.6 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal EBP PF05241.12 EDP44315.1 - 6.6e-54 182.0 8.0 7.4e-54 181.9 8.0 1.0 1 0 0 1 1 1 1 Emopamil binding protein Bromodomain PF00439.25 EDP44317.1 - 1.9e-24 85.5 0.1 4e-24 84.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EDP44317.1 - 3.9e-10 40.0 0.0 8.5e-10 38.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EDP44317.1 - 2.3e-06 27.5 0.0 4.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EDP44317.1 - 5e-05 23.6 0.0 9.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ANTH PF07651.16 EDP44318.1 - 1.1e-32 113.2 3.4 1.7e-32 112.5 3.4 1.3 1 0 0 1 1 1 1 ANTH domain DUF2431 PF10354.9 EDP44320.1 - 2.2e-36 125.6 0.0 3e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FAM176 PF14851.6 EDP44320.1 - 0.078 12.6 0.0 0.49 10.0 0.0 1.9 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 EDP44320.1 - 0.11 12.5 0.6 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 RXT2-like, N-terminal TALPID3 PF15324.6 EDP44320.1 - 0.16 9.6 0.2 0.24 9.1 0.2 1.2 1 0 0 1 1 1 0 Hedgehog signalling target AIM3 PF17096.5 EDP44320.1 - 0.64 11.0 7.4 2.8 8.9 1.1 2.3 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 PBP1_TM PF14812.6 EDP44320.1 - 0.77 10.2 5.4 0.36 11.2 1.7 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DnaJ PF00226.31 EDP44321.1 - 2.2e-19 69.3 0.1 6.8e-19 67.8 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 EDP44321.1 - 3.6e-15 55.1 0.5 0.042 13.7 0.1 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44321.1 - 1.1e-14 53.2 6.5 0.003 17.5 0.2 8.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44321.1 - 1.8e-14 54.0 14.8 0.0063 17.0 0.6 7.2 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 EDP44321.1 - 7.5e-12 45.2 6.2 1.7e-06 28.1 0.2 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44321.1 - 1e-09 37.8 1.1 0.29 11.5 0.0 6.0 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44321.1 - 6e-09 36.4 9.5 0.0039 17.8 2.0 4.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44321.1 - 6.5e-08 32.8 14.3 0.029 15.2 0.5 7.0 5 4 4 9 9 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44321.1 - 1.5e-07 30.9 0.7 0.006 16.2 0.3 4.0 4 0 0 4 4 3 2 TPR repeat ANAPC3 PF12895.7 EDP44321.1 - 7.5e-07 29.3 8.3 0.0026 17.9 0.1 4.9 2 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDP44321.1 - 9.2e-07 28.8 0.3 0.05 14.0 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP44321.1 - 2e-06 28.0 18.3 3.3 8.6 0.0 8.4 8 2 1 9 9 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44321.1 - 0.0033 17.7 12.6 0.18 12.1 0.1 5.4 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 EDP44321.1 - 0.0037 17.6 3.9 0.26 11.7 0.1 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat BTAD PF03704.17 EDP44321.1 - 0.0049 17.3 6.2 6.9 7.1 0.3 4.2 2 1 2 4 4 4 0 Bacterial transcriptional activator domain MIT PF04212.18 EDP44321.1 - 0.011 15.7 4.4 0.28 11.3 0.1 3.4 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 EDP44321.1 - 0.016 15.4 1.1 23 5.5 0.0 4.4 4 0 0 4 4 4 0 PPR repeat TPR_3 PF07720.12 EDP44321.1 - 0.038 14.0 0.2 1.9 8.6 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EDP44321.1 - 0.043 13.5 0.8 0.65 9.6 0.0 3.2 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 EDP44321.1 - 0.046 13.8 6.4 0.87 9.8 0.0 5.4 5 1 0 5 5 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 EDP44321.1 - 0.065 13.3 0.4 5.1 7.2 0.0 3.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) Cas_Cas02710 PF09670.10 EDP44321.1 - 0.094 11.5 2.9 0.067 12.0 0.5 2.0 2 1 0 2 2 2 0 CRISPR-associated protein (Cas_Cas02710) SRP_TPR_like PF17004.5 EDP44321.1 - 0.12 12.4 2.2 11 6.0 1.7 3.0 2 1 0 2 2 2 0 Putative TPR-like repeat PPR_2 PF13041.6 EDP44321.1 - 0.14 12.4 0.6 40 4.5 0.0 3.2 3 0 0 3 3 2 0 PPR repeat family Alkyl_sulf_dimr PF14863.6 EDP44321.1 - 0.52 10.8 9.1 8.1 6.9 0.4 4.0 2 1 1 3 3 3 0 Alkyl sulfatase dimerisation Spectrin PF00435.21 EDP44321.1 - 0.62 10.6 9.1 3.2 8.3 0.6 3.7 4 0 0 4 4 3 0 Spectrin repeat TPR_21 PF09976.9 EDP44321.1 - 1 9.0 11.6 0.52 10.0 0.7 3.3 2 2 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 EDP44321.1 - 2.5 8.1 9.4 8.3 6.4 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Bax1-I PF01027.20 EDP44322.1 - 1.7e-43 148.9 24.0 1.9e-43 148.7 24.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2070 PF09843.9 EDP44322.1 - 0.035 12.4 12.0 0.045 12.1 12.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) BaxI_1 PF12811.7 EDP44322.1 - 0.16 11.5 16.6 0.74 9.3 16.6 2.0 1 1 0 1 1 1 0 Bax inhibitor 1 like Fe-S_biosyn PF01521.20 EDP44323.1 - 1.8e-18 66.7 0.0 2.5e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis MMR_HSR1 PF01926.23 EDP44324.1 - 1.6e-20 73.3 0.0 2.6e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP44324.1 - 1.3e-07 31.3 0.0 1.1e-05 25.0 0.0 2.8 2 1 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EDP44324.1 - 0.00019 21.0 0.0 0.061 12.9 0.0 2.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EDP44324.1 - 0.0014 18.7 0.1 1.1 9.3 0.0 2.2 1 1 1 2 2 2 2 Dynamin family ABC_tran PF00005.27 EDP44324.1 - 0.0015 19.0 0.0 0.0031 18.0 0.0 1.7 1 1 0 1 1 1 1 ABC transporter Arf PF00025.21 EDP44324.1 - 0.0015 18.0 0.0 0.23 10.9 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_18 PF13238.6 EDP44324.1 - 0.0025 18.4 0.0 0.0039 17.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EDP44324.1 - 0.0055 16.2 0.0 0.05 13.0 0.0 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MeaB PF03308.16 EDP44324.1 - 0.11 11.5 0.0 0.53 9.2 0.0 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Serinc PF03348.15 EDP44325.1 - 1.8e-137 458.8 12.9 2.2e-137 458.5 12.9 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF2231 PF09990.9 EDP44325.1 - 0.03 14.8 0.1 0.03 14.8 0.1 3.7 3 1 2 5 5 5 0 Predicted membrane protein (DUF2231) TMEM223 PF14640.6 EDP44325.1 - 5.5 7.1 6.6 30 4.7 0.5 3.8 3 1 1 4 4 4 0 Transmembrane protein 223 PEN-2 PF10251.9 EDP44325.1 - 9 6.8 9.2 1.1 9.7 1.8 2.7 2 1 0 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase Pterin_bind PF00809.22 EDP44326.1 - 2.6e-73 246.7 0.1 9.7e-73 244.8 0.1 1.8 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EDP44326.1 - 2.1e-37 128.0 0.0 3.4e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 EDP44327.1 - 1e-19 71.1 0.0 5.7e-16 59.0 0.0 2.1 2 0 0 2 2 2 2 Dihydroneopterin aldolase HEAT PF02985.22 EDP44328.1 - 0.38 11.1 2.1 1.8 9.1 0.1 3.3 3 1 0 3 3 3 0 HEAT repeat DNA_pol_E_B PF04042.16 EDP44329.1 - 3.6e-42 144.1 0.1 6e-42 143.4 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 EDP44329.1 - 0.067 13.5 0.1 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal DUF2428 PF10350.9 EDP44330.1 - 2.3e-45 155.0 2.3 5.3e-45 153.8 2.3 1.7 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EDP44330.1 - 0.019 15.2 7.5 0.063 13.6 0.2 4.1 3 0 0 3 3 3 0 HEAT repeat Adaptin_N PF01602.20 EDP44330.1 - 0.11 11.0 4.3 0.082 11.4 0.2 2.5 3 0 0 3 3 3 0 Adaptin N terminal region HEAT_2 PF13646.6 EDP44330.1 - 0.61 10.5 6.9 1.5 9.3 0.1 3.9 3 1 0 3 3 3 0 HEAT repeats PIGA PF08288.12 EDP44331.1 - 2.3e-40 137.0 0.2 5.1e-40 135.9 0.2 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EDP44331.1 - 1.5e-28 99.9 1.2 2.6e-28 99.1 1.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EDP44331.1 - 2.9e-23 82.3 0.0 4.5e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDP44331.1 - 1.6e-19 70.7 0.0 3.5e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EDP44331.1 - 6.5e-11 42.9 0.5 6.5e-11 42.9 0.5 1.8 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EDP44331.1 - 0.00011 22.2 0.0 0.00021 21.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like tRNA-synt_2c PF01411.19 EDP44332.1 - 1.6e-218 726.7 0.0 2.1e-218 726.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EDP44332.1 - 1.1e-15 57.4 0.2 2.7e-15 56.2 0.2 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EDP44332.1 - 1.7e-09 38.2 2.4 4.3e-09 36.9 2.4 1.7 1 0 0 1 1 1 1 DHHA1 domain zf-C2H2 PF00096.26 EDP44333.1 - 3.2e-11 43.0 24.1 1.1e-05 25.6 1.0 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EDP44333.1 - 7.1e-11 41.8 2.8 6.1e-05 22.9 0.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EDP44333.1 - 6.6e-07 29.6 21.5 0.0053 17.5 0.4 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP44333.1 - 2.2e-06 27.8 7.4 0.0006 20.1 0.1 4.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-met PF12874.7 EDP44333.1 - 0.039 14.4 1.9 7.6 7.1 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EDP44333.1 - 0.045 13.7 7.4 0.26 11.2 0.3 2.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 EDP44333.1 - 0.32 11.3 6.0 2.5 8.5 5.2 2.5 1 1 1 2 2 2 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 EDP44333.1 - 0.44 10.7 8.1 0.31 11.2 0.4 3.3 3 1 1 4 4 4 0 Zinc ribbon domain FOXP-CC PF16159.5 EDP44333.1 - 0.55 10.9 7.1 5.8 7.6 4.0 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain IBR PF01485.21 EDP44333.1 - 4.9 7.5 9.2 77 3.6 7.8 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain adh_short PF00106.25 EDP44334.1 - 0.0044 16.5 0.0 0.0059 16.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Aldedh PF00171.22 EDP44336.1 - 5.9e-184 611.9 0.1 6.7e-184 611.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EDP44336.1 - 0.0017 17.9 0.0 0.0082 15.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) BMC PF00936.19 EDP44336.1 - 0.059 13.4 0.6 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 BMC domain Sugar_tr PF00083.24 EDP44337.1 - 1.2e-51 176.0 13.5 1.5e-51 175.7 13.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EDP44337.1 - 3.6e-11 42.6 10.2 4.4e-11 42.3 10.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1156 PF06634.12 EDP44337.1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) Bax1-I PF01027.20 EDP44337.1 - 0.69 9.7 13.5 3.9 7.3 13.2 2.1 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 TB2_DP1_HVA22 PF03134.19 EDP44337.1 - 2.8 8.0 7.1 0.37 10.7 2.7 1.9 2 0 0 2 2 2 0 TB2/DP1, HVA22 family HLH PF00010.26 EDP44338.1 - 1.8e-06 27.8 0.0 9.1e-06 25.6 0.0 2.3 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Haspin_kinase PF12330.8 EDP44339.1 - 4.1e-52 177.3 0.5 5.3e-52 177.0 0.5 1.0 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP44339.1 - 0.016 15.1 0.1 0.016 15.1 0.1 2.2 2 1 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L1 PF00687.21 EDP44340.1 - 5.1e-20 72.1 0.0 3.6e-19 69.3 0.0 2.2 2 1 1 3 3 3 1 Ribosomal protein L1p/L10e family IF-2 PF11987.8 EDP44340.1 - 0.15 12.2 0.1 0.55 10.4 0.1 1.9 1 1 1 2 2 2 0 Translation-initiation factor 2 CGI-121 PF08617.10 EDP44343.1 - 1.8e-45 155.0 0.0 2.1e-45 154.8 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Pribosyltran PF00156.27 EDP44344.1 - 7.2e-14 51.6 0.0 9.5e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EDP44344.1 - 4.7e-05 22.9 0.0 7.6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF1699 PF08004.11 EDP44345.1 - 0.29 10.8 1.1 0.73 9.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1699) HpcH_HpaI PF03328.14 EDP44346.1 - 8.4e-19 67.6 0.2 9.5e-19 67.4 0.2 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EDP44346.1 - 0.041 13.1 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold ABC_tran PF00005.27 EDP44347.1 - 5.6e-37 127.3 0.0 1.4e-36 126.0 0.0 1.8 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EDP44347.1 - 2.5e-36 125.8 11.0 4.3e-36 125.0 11.0 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EDP44347.1 - 1.1e-05 25.0 0.0 0.0021 17.5 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EDP44347.1 - 9.2e-05 22.9 0.1 0.00022 21.6 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EDP44347.1 - 0.00055 19.8 0.0 0.00083 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EDP44347.1 - 0.00085 19.0 0.0 0.0025 17.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EDP44347.1 - 0.0013 18.7 0.0 0.0037 17.1 0.0 1.7 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EDP44347.1 - 0.0086 16.4 0.0 0.095 13.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EDP44347.1 - 0.0091 15.9 0.0 0.049 13.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EDP44347.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit IstB_IS21 PF01695.17 EDP44347.1 - 0.02 14.7 0.1 0.072 12.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 EDP44347.1 - 0.048 13.2 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EDP44347.1 - 0.056 13.4 0.0 0.49 10.4 0.0 2.3 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.7 EDP44347.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.6 EDP44347.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain HCMVantigenic_N PF12154.8 EDP44348.1 - 6 7.1 7.9 1.2 9.3 1.6 2.4 2 0 0 2 2 2 0 Glycoprotein B N-terminal antigenic domain of HCMV BCDHK_Adom3 PF10436.9 EDP44349.1 - 5.7e-45 153.1 0.0 7.9e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDP44349.1 - 1.9e-09 38.0 0.0 4.2e-09 36.9 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EDP44349.1 - 3.4e-05 23.7 0.0 5.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase V-SNARE PF05008.15 EDP44350.1 - 7.7e-18 64.7 0.9 7.7e-18 64.7 0.9 1.7 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EDP44350.1 - 9.9e-11 41.8 0.8 9.9e-11 41.8 0.8 2.1 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus BORCS6 PF10157.9 EDP44350.1 - 0.091 13.0 0.6 0.2 11.9 0.1 1.7 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 6 Gluconate_2-dh3 PF13618.6 EDP44350.1 - 2.2 8.5 4.2 1.2 9.3 0.5 2.1 1 1 1 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 WD40 PF00400.32 EDP44351.1 - 5.8e-12 45.9 7.3 0.0028 18.4 0.4 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44351.1 - 4.7e-08 33.2 0.0 0.082 13.2 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain IGR PF09597.10 EDP44352.1 - 1.5e-14 53.8 0.0 2.6e-14 53.1 0.0 1.5 1 1 0 1 1 1 1 IGR protein motif PAF-AH_p_II PF03403.13 EDP44353.1 - 4.5e-43 147.2 0.9 5.4e-22 77.8 0.0 4.1 2 1 0 3 3 3 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EDP44353.1 - 2.5e-07 29.9 0.0 7.8e-06 25.0 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EDP44353.1 - 1.1e-06 28.1 0.0 0.00047 19.5 0.4 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EDP44353.1 - 1.4e-05 24.9 0.0 0.39 10.3 0.0 3.1 3 0 0 3 3 3 2 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EDP44353.1 - 4.5e-05 22.6 0.0 0.00041 19.5 0.0 2.0 2 0 0 2 2 2 1 Chlorophyllase Abhydrolase_6 PF12697.7 EDP44353.1 - 0.032 14.8 0.1 0.51 10.9 0.0 2.5 2 1 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EDP44353.1 - 0.061 12.8 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family UQ_con PF00179.26 EDP44354.1 - 1.1e-38 132.0 0.0 1.4e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EDP44354.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain AMP-binding PF00501.28 EDP44355.1 - 1e-83 281.3 0.0 1.3e-83 281.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDP44355.1 - 2e-12 47.9 0.0 5e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EDP44355.1 - 0.00083 18.3 0.0 0.0058 15.5 0.0 2.2 2 1 1 3 3 3 1 GH3 auxin-responsive promoter Carb_kinase PF01256.17 EDP44356.1 - 7.1e-35 120.6 0.0 8.3e-35 120.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase ribosomal_L24 PF17136.4 EDP44357.1 - 0.0052 17.2 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 dCMP_cyt_deam_2 PF08211.12 EDP44358.1 - 2.8e-08 34.0 0.1 3.2e-08 33.9 0.1 1.0 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.23 EDP44358.1 - 3.6e-05 23.6 0.0 4.1e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Hydantoinase_A PF01968.18 EDP44359.1 - 3.2e-98 328.6 1.1 6.1e-98 327.7 1.1 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EDP44359.1 - 5.1e-62 208.7 0.2 5.7e-60 202.0 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region WD40 PF00400.32 EDP44360.1 - 0.0052 17.6 0.2 0.89 10.5 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat GST_C_6 PF17171.4 EDP44361.1 - 3.2e-07 30.0 0.0 3e-06 26.9 0.0 2.5 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDP44361.1 - 0.00028 20.9 0.4 0.00061 19.8 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDP44361.1 - 0.097 13.4 0.1 0.24 12.2 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase N-terminal domain SAM35 PF10806.8 EDP44361.1 - 0.19 12.0 0.0 2.4 8.5 0.0 2.2 1 1 1 2 2 2 0 SAM35, subunit of SAM coomplex Mito_carr PF00153.27 EDP44362.1 - 6.5e-44 147.8 1.1 7.6e-15 54.6 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Coatomer_E PF04733.14 EDP44363.1 - 1.5e-31 110.0 1.6 1.6e-31 109.8 1.6 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_2 PF07719.17 EDP44363.1 - 0.00027 20.8 2.7 0.77 10.0 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDP44363.1 - 0.00045 20.6 2.7 0.76 10.6 2.5 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44363.1 - 0.00046 20.6 5.8 2.6 8.6 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44363.1 - 0.0012 19.4 8.0 1.8 9.3 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44363.1 - 0.0073 16.5 0.2 3.8 7.8 0.0 2.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EDP44363.1 - 0.01 16.6 8.5 11 7.2 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44363.1 - 0.015 15.1 0.0 2.8 7.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.8 EDP44363.1 - 0.016 14.1 0.1 0.88 8.4 0.1 2.0 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 TPR_11 PF13414.6 EDP44363.1 - 0.021 14.5 3.2 0.12 12.0 0.1 2.9 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 EDP44363.1 - 0.038 14.6 3.2 9.2 7.1 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat peroxidase PF00141.23 EDP44364.1 - 3.1e-48 164.5 0.0 5.1e-48 163.8 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Casc1 PF12366.8 EDP44364.1 - 0.032 13.8 0.1 0.052 13.1 0.1 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 DUF1972 PF09314.11 EDP44364.1 - 0.11 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) GDI PF00996.18 EDP44366.1 - 1.3e-169 564.3 0.0 1.5e-169 564.1 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor YflT PF11181.8 EDP44367.1 - 0.019 15.5 0.1 0.023 15.2 0.1 1.2 1 0 0 1 1 1 0 Heat induced stress protein YflT Ribosomal_L22 PF00237.19 EDP44368.1 - 1.3e-25 89.6 0.1 2.1e-25 88.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Aldedh PF00171.22 EDP44369.1 - 3.4e-158 526.9 0.0 3.9e-158 526.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EDP44369.1 - 0.011 14.8 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EDP44369.1 - 0.09 12.2 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Thx PF17070.5 EDP44369.1 - 0.11 12.6 0.7 0.32 11.2 0.7 1.7 1 0 0 1 1 1 0 30S ribosomal protein Thx Pro_isomerase PF00160.21 EDP44370.1 - 1.2e-46 158.9 0.0 1.4e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RhoGAP PF00620.27 EDP44371.1 - 3e-36 124.5 0.3 6.5e-36 123.4 0.3 1.5 1 0 0 1 1 1 1 RhoGAP domain UBN_AB PF14075.6 EDP44371.1 - 0.001 18.9 0.3 0.0033 17.2 0.3 1.8 1 0 0 1 1 1 1 Ubinuclein conserved middle domain IFT46_B_C PF12317.8 EDP44371.1 - 0.095 12.4 0.9 2.4 7.8 0.2 2.7 2 1 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Pro_isomerase PF00160.21 EDP44372.1 - 3.4e-47 160.7 0.1 5.1e-47 160.1 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EDP44372.1 - 9.4e-07 28.5 6.7 0.0001 22.1 0.5 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44372.1 - 6.6e-06 25.7 3.8 7.5e-05 22.4 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44372.1 - 0.0022 18.1 0.2 0.0022 18.1 0.2 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP44372.1 - 0.027 15.1 2.8 0.69 10.7 0.4 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_92 PF07971.12 EDP44372.1 - 0.15 10.9 0.2 0.2 10.6 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 TPR_11 PF13414.6 EDP44372.1 - 0.24 11.1 5.9 1.3 8.7 0.3 3.1 2 1 1 3 3 3 0 TPR repeat Aminotran_5 PF00266.19 EDP44373.1 - 3.4e-30 105.2 0.0 5.5e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V EFG_C PF00679.24 EDP44373.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G C-terminus Methyltransf_16 PF10294.9 EDP44374.1 - 4.3e-10 39.6 0.0 2.9e-09 36.9 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase P34-Arc PF04045.14 EDP44375.1 - 8.8e-83 277.7 0.0 1.1e-82 277.3 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc PGP_phosphatase PF09419.10 EDP44376.1 - 9.9e-37 126.1 0.0 1.8e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase DUF1764 PF08576.10 EDP44377.1 - 3.9e-07 30.9 15.4 3.6e-06 27.8 7.0 2.7 1 1 2 3 3 3 2 Eukaryotic protein of unknown function (DUF1764) HGTP_anticodon2 PF12745.7 EDP44377.1 - 1.1 8.7 8.2 1.5 8.3 8.2 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DSHCT PF08148.12 EDP44378.1 - 8.5e-47 158.9 0.2 3e-46 157.1 0.1 2.0 2 0 0 2 2 2 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EDP44378.1 - 2.1e-29 102.0 0.0 5e-29 100.8 0.0 1.6 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EDP44378.1 - 6.6e-20 72.2 0.3 1.1e-19 71.4 0.3 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EDP44378.1 - 2.7e-18 66.3 0.0 5.5e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EDP44378.1 - 2.2e-07 31.0 0.0 3.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EDP44378.1 - 3.4e-05 24.2 0.0 0.00022 21.6 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EDP44378.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Arrestin_N PF00339.29 EDP44379.1 - 2.5e-05 24.4 0.0 7.7e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain PC-Esterase PF13839.6 EDP44380.1 - 0.0015 18.3 0.4 0.015 15.1 0.0 2.2 2 1 0 2 2 2 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p I_LWEQ PF01608.17 EDP44381.1 - 2.6e-53 180.4 7.7 2.6e-53 180.4 7.7 5.7 4 2 2 6 6 6 2 I/LWEQ domain ANTH PF07651.16 EDP44381.1 - 1.7e-40 138.8 0.2 1.7e-40 138.8 0.2 2.6 2 0 0 2 2 2 1 ANTH domain FAA_hydro_N_2 PF18288.1 EDP44381.1 - 0.079 13.4 2.8 0.15 12.5 0.2 2.8 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 TPR_14 PF13428.6 EDP44382.1 - 3.1e-11 43.1 7.0 0.0088 16.8 0.0 6.0 4 2 2 6 6 6 3 Tetratricopeptide repeat Suf PF05843.14 EDP44382.1 - 3.9e-08 33.6 0.0 2.2e-06 27.9 0.0 2.4 1 1 2 3 3 3 1 Suppressor of forked protein (Suf) TPR_6 PF13174.6 EDP44382.1 - 1e-05 25.8 1.7 0.026 15.2 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44382.1 - 1.5e-05 24.8 4.5 0.16 12.2 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44382.1 - 1.9e-05 25.1 4.1 0.093 13.3 0.0 4.2 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44382.1 - 9.2e-05 22.4 0.0 1.6 9.1 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44382.1 - 0.00029 21.4 10.5 0.14 12.8 0.3 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44382.1 - 0.00032 20.9 6.1 0.68 10.3 0.1 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 EDP44382.1 - 0.001 19.5 2.6 3.3 8.6 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDP44382.1 - 0.0012 18.7 7.5 3 7.9 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat RPN7 PF10602.9 EDP44382.1 - 0.033 13.9 0.5 0.13 12.0 0.2 2.2 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 EDP44382.1 - 0.058 13.2 0.0 6 6.9 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EDP44382.1 - 0.07 13.2 0.1 0.25 11.4 0.1 2.0 1 1 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 TPR_9 PF13371.6 EDP44382.1 - 0.47 10.6 5.4 1 9.6 0.3 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat S1 PF00575.23 EDP44383.1 - 4.9e-40 135.7 18.1 5.8e-14 52.2 0.4 10.1 8 2 1 9 9 9 7 S1 RNA binding domain RNase_II_C_S1 PF18614.1 EDP44383.1 - 0.24 11.4 13.1 24 5.0 0.3 6.8 5 0 0 5 5 5 0 RNase II-type exonuclease C-terminal S1 domain TRAM PF01938.20 EDP44383.1 - 0.3 11.1 1.6 43 4.2 0.0 3.8 4 0 0 4 4 4 0 TRAM domain Peptidase_M28 PF04389.17 EDP44384.1 - 6.2e-28 97.9 0.0 6.9e-27 94.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDP44384.1 - 3.4e-08 33.4 0.0 5.3e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 EF-hand_6 PF13405.6 EDP44384.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain DNA_pol_B_palm PF14792.6 EDP44386.1 - 5.9e-17 61.9 0.2 1.1e-16 61.1 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 EDP44386.1 - 3.4e-11 43.3 0.0 2.8e-10 40.4 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EDP44386.1 - 3e-07 30.1 0.0 9.8e-07 28.5 0.0 1.8 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.6 EDP44386.1 - 1.2e-05 25.4 0.1 2.5e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_5 PF14520.6 EDP44386.1 - 0.00011 22.8 0.0 0.16 12.6 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EDP44386.1 - 0.0017 18.6 0.0 0.0033 17.7 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH PF00633.23 EDP44386.1 - 0.02 14.7 0.0 0.77 9.8 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif IMS_HHH PF11798.8 EDP44386.1 - 0.12 12.8 0.0 17 6.0 0.0 2.7 2 0 0 2 2 2 0 IMS family HHH motif Aminotran_1_2 PF00155.21 EDP44387.1 - 3.7e-91 306.0 0.0 4.2e-91 305.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Rav1p_C PF12234.8 EDP44388.1 - 6.7e-99 332.0 9.2 2e-91 307.3 0.4 2.5 3 0 0 3 3 3 2 RAVE protein 1 C terminal ANAPC4_WD40 PF12894.7 EDP44388.1 - 0.021 15.1 1.0 0.21 11.9 0.1 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LIDHydrolase PF10230.9 EDP44389.1 - 2.2e-29 102.9 0.0 2.6e-29 102.6 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 EDP44389.1 - 1.5e-08 34.6 0.1 2.2e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP44389.1 - 2.2e-06 28.4 1.8 2.9e-06 28.1 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP44389.1 - 4.5e-06 26.1 1.0 5.9e-06 25.7 0.2 1.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EDP44389.1 - 0.0028 17.8 0.0 0.0045 17.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EDP44389.1 - 0.0032 17.1 0.0 0.0054 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 EDP44389.1 - 0.0039 16.9 0.3 0.014 15.1 0.3 1.8 1 1 0 1 1 1 1 PGAP1-like protein DUF2920 PF11144.8 EDP44389.1 - 0.015 14.5 0.0 0.076 12.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) DUF282 PF03380.14 EDP44389.1 - 0.1 12.5 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF282 DUF3089 PF11288.8 EDP44389.1 - 0.18 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF900 PF05990.12 EDP44389.1 - 0.27 10.7 0.1 0.39 10.2 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Sec3-PIP2_bind PF15277.6 EDP44390.1 - 3.6e-07 30.2 0.0 5.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C PF09763.9 EDP44391.1 - 7.7e-137 457.6 0.6 3e-135 452.3 0.6 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec3 GAT PF03127.14 EDP44391.1 - 0.28 11.5 2.6 2.9 8.2 0.1 3.7 3 1 0 3 3 3 0 GAT domain Vps52 PF04129.12 EDP44391.1 - 0.51 9.0 4.6 1.6 7.4 2.1 2.7 3 0 0 3 3 3 0 Vps52 / Sac2 family K_oxygenase PF13434.6 EDP44392.1 - 1e-93 314.2 0.0 2.7e-93 312.8 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EDP44392.1 - 6.9e-05 22.9 0.0 0.00064 19.7 0.0 2.4 3 0 0 3 3 3 1 FAD-NAD(P)-binding Prok-E2_E PF14462.6 EDP44392.1 - 0.0034 17.2 0.1 0.023 14.5 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic E2 family E Acetyltransf_8 PF13523.6 EDP44393.1 - 1.1e-43 148.4 0.2 1.7e-43 147.8 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PORR PF11955.8 EDP44394.1 - 0.16 10.9 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Plant organelle RNA recognition domain HIT PF01230.23 EDP44395.1 - 2.4e-08 34.6 2.6 5.3e-07 30.3 2.6 2.2 1 1 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EDP44395.1 - 3.5e-08 33.9 9.9 1.3e-05 25.6 9.9 2.7 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding fn3_4 PF16794.5 EDP44395.1 - 0.085 12.8 0.1 0.31 11.0 0.0 1.8 1 1 1 2 2 2 0 Fibronectin-III type domain CS PF04969.16 EDP44396.1 - 3.6e-10 40.7 0.0 9.2e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 CS domain DUF2388 PF09498.10 EDP44396.1 - 0.04 13.9 0.7 0.44 10.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2388) DUF5462 PF17547.2 EDP44396.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5462) Cwf_Cwc_15 PF04889.12 EDP44397.1 - 0.00041 20.2 1.4 0.00098 18.9 1.4 1.6 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein HA2 PF04408.23 EDP44398.1 - 1.2e-16 60.9 3.7 2.2e-16 60.1 0.0 3.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDP44398.1 - 6.9e-14 52.1 0.0 1.8e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP44398.1 - 2.4e-09 37.2 0.1 6e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EDP44398.1 - 8.9e-09 35.6 0.0 4e-08 33.5 0.1 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 EDP44398.1 - 2.7e-06 27.7 0.5 5e-05 23.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EDP44398.1 - 0.008 16.5 0.0 0.031 14.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EDP44398.1 - 0.011 15.0 0.0 0.03 13.7 0.0 1.6 1 0 0 1 1 1 0 KaiC T2SSE PF00437.20 EDP44398.1 - 0.015 14.4 0.0 0.038 13.1 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EDP44398.1 - 0.022 15.3 4.0 10 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP44398.1 - 0.081 13.4 1.3 0.24 11.9 0.0 2.5 3 0 0 3 3 3 0 ABC transporter PhzC-PhzF PF02567.16 EDP44399.1 - 5.7e-52 176.9 0.0 6.6e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 EDP44399.1 - 0.086 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Proline racemase AA_permease_2 PF13520.6 EDP44400.1 - 1e-68 232.1 33.2 1e-68 232.1 33.2 1.2 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDP44400.1 - 2.4e-17 62.7 28.8 3.6e-17 62.1 28.8 1.2 1 0 0 1 1 1 1 Amino acid permease SUR7 PF06687.12 EDP44400.1 - 2.6 7.6 9.9 0.71 9.5 0.0 2.7 2 1 0 2 2 2 0 SUR7/PalI family Homeodomain PF00046.29 EDP44401.1 - 3e-06 27.0 3.3 2.4e-05 24.1 3.3 2.3 1 1 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EDP44401.1 - 0.034 14.1 0.1 0.097 12.6 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeobox_KN PF05920.11 EDP44402.1 - 3.7e-19 68.3 0.9 8.1e-19 67.3 0.9 1.6 1 0 0 1 1 1 1 Homeobox KN domain Ustilago_mating PF05722.12 EDP44402.1 - 0.0018 17.9 0.3 0.0041 16.7 0.3 1.6 1 1 0 1 1 1 1 Ustilago B locus mating-type protein Mating_N PF12731.7 EDP44402.1 - 0.012 15.6 1.3 0.025 14.7 1.3 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 Homeodomain PF00046.29 EDP44402.1 - 0.038 13.8 0.2 0.12 12.2 0.2 1.9 1 0 0 1 1 1 0 Homeodomain T2SSF PF00482.23 EDP44402.1 - 0.32 10.9 1.3 4.3 7.3 0.0 2.6 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Sas10_Utp3 PF04000.15 EDP44403.1 - 8.7e-12 45.5 0.3 8.7e-12 45.5 0.3 2.0 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Lung_7-TM_R PF06814.13 EDP44405.1 - 1.3e-49 169.0 24.1 3.1e-49 167.8 24.1 1.5 1 1 0 1 1 1 1 Lung seven transmembrane receptor DUF4079 PF13301.6 EDP44405.1 - 0.099 12.8 0.2 0.099 12.8 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) CrgA PF06781.12 EDP44405.1 - 0.46 10.6 5.3 0.093 12.8 0.6 2.4 2 0 0 2 2 2 0 Cell division protein CrgA CWC25 PF12542.8 EDP44406.1 - 1.4e-24 86.9 1.0 1.4e-24 86.9 1.0 4.0 4 1 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EDP44406.1 - 2.5e-13 50.0 15.6 2.5e-13 50.0 15.6 3.8 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR RNA_pol_Rpb2_6 PF00562.28 EDP44407.1 - 1.9e-124 415.7 0.1 3.3e-124 414.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDP44407.1 - 5.8e-64 215.3 0.0 8.5e-64 214.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDP44407.1 - 2.8e-48 164.1 0.0 5.1e-48 163.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDP44407.1 - 5.7e-31 106.8 0.2 1.5e-30 105.4 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDP44407.1 - 1.1e-25 89.7 0.2 3e-25 88.3 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDP44407.1 - 2.9e-25 88.2 0.1 6.6e-25 87.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDP44407.1 - 1e-21 77.2 0.2 3.3e-21 75.6 0.2 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Nop25 PF09805.9 EDP44409.1 - 0.041 14.4 0.7 0.041 14.4 0.7 1.7 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) GxDLY PF14607.6 EDP44409.1 - 0.41 10.4 1.6 5.6 6.7 0.0 2.9 2 1 1 3 3 3 0 N-terminus of Esterase_SGNH_hydro-type RMI1_N PF08585.12 EDP44410.1 - 2.7e-26 92.7 2.8 2.3e-25 89.7 0.0 3.0 2 1 0 2 2 2 1 RecQ mediated genome instability protein 2-oxoacid_dh PF00198.23 EDP44411.1 - 3.6e-79 265.5 0.2 5.2e-79 265.0 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EDP44411.1 - 4.4e-19 68.1 0.4 1.1e-18 66.7 0.4 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDP44411.1 - 3.8e-13 49.5 0.3 1e-12 48.1 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain ABATE PF07336.11 EDP44411.1 - 0.003 18.2 1.3 0.003 18.2 1.3 2.1 2 0 0 2 2 2 1 Putative stress-induced transcription regulator RNA_pol_Rpc4 PF05132.14 EDP44411.1 - 0.068 13.6 6.5 0.099 13.1 5.4 1.8 1 1 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 EDP44411.1 - 0.14 10.4 2.1 0.17 10.1 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EDP44411.1 - 0.33 9.7 1.0 0.39 9.4 1.0 1.2 1 0 0 1 1 1 0 Presenilin DUF5521 PF17659.1 EDP44411.1 - 0.36 8.6 4.1 0.5 8.1 4.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) Tim54 PF11711.8 EDP44411.1 - 0.58 8.9 4.7 0.95 8.2 4.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SspB PF04386.13 EDP44411.1 - 0.67 9.8 8.1 25 4.7 6.4 2.4 2 0 0 2 2 2 0 Stringent starvation protein B RR_TM4-6 PF06459.12 EDP44411.1 - 1.2 8.9 6.3 2 8.2 6.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRP-alpha_N PF04086.13 EDP44411.1 - 2.1 8.2 13.4 4 7.3 13.4 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Coilin_N PF15862.5 EDP44411.1 - 6.3 6.6 7.2 13 5.6 7.2 1.4 1 0 0 1 1 1 0 Coilin N-terminus WES_acyltransf PF03007.16 EDP44412.1 - 1.9e-16 60.6 0.1 4.3e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 EDP44412.1 - 6.4e-10 39.2 0.0 2.1e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1298) AATase PF07247.12 EDP44412.1 - 0.13 10.7 0.0 0.21 10.1 0.0 1.3 1 0 0 1 1 1 0 Alcohol acetyltransferase LTV PF04180.14 EDP44413.1 - 4.1e-43 148.6 6.3 4.1e-43 148.6 6.3 2.8 3 0 0 3 3 3 2 Low temperature viability protein EXOSC1 PF10447.9 EDP44414.1 - 1.7e-24 86.5 0.5 2.8e-23 82.6 0.5 2.1 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 S1 PF00575.23 EDP44414.1 - 0.13 12.6 0.0 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 S1 RNA binding domain Sperm_Ag_HE2 PF05324.13 EDP44414.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.6 1 0 0 1 1 1 0 Sperm antigen HE2 PPR_2 PF13041.6 EDP44415.1 - 4.5e-07 30.0 0.1 0.0029 17.8 0.0 5.1 6 0 0 6 6 6 2 PPR repeat family PPR_long PF17177.4 EDP44415.1 - 0.051 12.9 0.0 0.53 9.6 0.0 2.4 2 1 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 EDP44415.1 - 0.084 13.0 0.0 5 7.3 0.0 3.1 2 1 1 3 3 3 0 Pentatricopeptide repeat domain GATA PF00320.27 EDP44416.1 - 1.4e-13 50.1 5.2 2.7e-13 49.3 5.2 1.5 1 0 0 1 1 1 1 GATA zinc finger Peptidase_M18 PF02127.15 EDP44417.1 - 2.2e-132 441.9 0.0 2.7e-132 441.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) UCH PF00443.29 EDP44418.1 - 1.4e-29 103.4 0.0 1.7e-29 103.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP44418.1 - 0.12 12.0 0.1 11 5.5 0.0 2.5 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase MFS_1 PF07690.16 EDP44419.1 - 2.2e-35 122.2 13.6 6e-35 120.8 14.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily HTH_32 PF13565.6 EDP44419.1 - 0.05 14.2 0.4 0.45 11.2 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain MFS_1 PF07690.16 EDP44420.1 - 5.3e-32 111.1 14.0 7.3e-32 110.7 14.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Bax1-I PF01027.20 EDP44420.1 - 6.4e-05 22.9 1.5 6.4e-05 22.9 1.5 3.1 3 0 0 3 3 3 1 Inhibitor of apoptosis-promoting Bax1 Anoctamin PF04547.12 EDP44420.1 - 0.054 12.3 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Calcium-activated chloride channel 4HBT PF03061.22 EDP44421.1 - 5e-07 30.0 0.1 9.9e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily Acatn PF13000.7 EDP44422.1 - 2e-151 505.2 26.5 7.6e-75 252.4 16.4 3.3 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 Iso_dh PF00180.20 EDP44423.1 - 2.2e-116 388.8 0.0 2.5e-116 388.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HrpE PF06188.12 EDP44424.1 - 0.32 10.8 3.4 0.4 10.5 0.1 2.6 3 1 0 3 3 3 0 HrpE/YscL/FliH and V-type ATPase subunit E Cation_efflux PF01545.21 EDP44425.1 - 1.6e-09 37.8 0.5 2e-09 37.5 0.5 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EDP44425.1 - 0.018 15.2 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter TPR_2 PF07719.17 EDP44426.1 - 1.7e-07 30.8 4.3 0.017 15.2 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44426.1 - 2.3e-07 31.0 6.5 0.0014 18.8 0.1 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44426.1 - 4.3e-05 23.2 1.9 0.88 9.7 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44426.1 - 7.9e-05 22.3 0.1 0.033 14.0 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44426.1 - 0.023 15.1 0.1 0.29 11.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP44426.1 - 0.056 14.1 3.3 0.16 12.6 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EDP44426.1 - 0.067 13.3 1.1 9.5 6.4 0.0 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EDP44426.1 - 0.12 12.3 16.2 0.14 12.0 0.0 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat zn-ribbon_14 PF16503.5 EDP44427.1 - 1.9e-17 62.4 2.6 1.9e-17 62.4 2.6 3.9 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 EDP44427.1 - 1.1e-15 57.8 0.0 1.9e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 EDP44427.1 - 0.0016 17.3 0.0 0.0024 16.7 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase TF_Zn_Ribbon PF08271.12 EDP44427.1 - 0.007 15.9 0.3 0.007 15.9 0.3 3.2 3 0 0 3 3 3 1 TFIIB zinc-binding RecR PF02132.15 EDP44427.1 - 0.03 13.9 1.7 0.03 13.9 1.7 2.6 3 0 0 3 3 3 0 RecR protein CTU2 PF10288.9 EDP44427.1 - 0.12 12.6 0.3 1.2 9.4 0.0 2.5 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 MMR_HSR1_Xtn PF16897.5 EDP44428.1 - 5e-42 142.2 0.5 3.5e-41 139.5 0.4 2.0 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EDP44428.1 - 1e-20 73.5 0.0 1.8e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EDP44428.1 - 2.6e-20 72.6 0.0 5e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP44428.1 - 6.4e-09 35.5 0.1 1.9e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EDP44428.1 - 0.058 12.4 0.6 0.15 11.0 0.6 1.7 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EDP44428.1 - 0.12 12.4 0.2 4.1 7.4 0.0 2.2 1 1 0 2 2 2 0 Dynamin family CBS PF00571.28 EDP44429.1 - 1.9e-05 25.0 0.5 0.11 13.0 0.0 2.7 2 1 0 2 2 2 2 CBS domain DUF21 PF01595.20 EDP44429.1 - 1.9e-05 24.4 0.0 3.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain RSN1_7TM PF02714.15 EDP44430.1 - 4.1e-62 210.0 21.1 4.1e-62 210.0 21.1 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EDP44430.1 - 5e-39 133.6 2.6 5e-39 133.6 2.6 3.3 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EDP44430.1 - 5.7e-36 124.4 0.1 9.4e-36 123.7 0.1 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EDP44430.1 - 1.9e-06 27.9 0.0 4.7e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter adh_short PF00106.25 EDP44431.1 - 8.7e-37 126.5 0.1 1.5e-36 125.7 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP44431.1 - 4.1e-23 82.2 0.2 6.7e-23 81.5 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF2470 PF10615.9 EDP44431.1 - 4.3e-18 65.7 3.3 7.6e-18 64.9 3.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) KR PF08659.10 EDP44431.1 - 3.5e-09 36.8 4.2 6.3e-08 32.7 0.3 3.4 3 1 0 3 3 3 1 KR domain Epimerase PF01370.21 EDP44431.1 - 0.043 13.3 0.0 0.086 12.3 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP44431.1 - 0.11 12.3 0.1 0.41 10.5 0.1 1.9 1 1 0 1 1 1 0 NAD(P)H-binding AhpC-TSA PF00578.21 EDP44432.1 - 3.7e-31 107.6 0.0 4.9e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EDP44432.1 - 2.5e-13 50.0 0.0 3.5e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EDP44432.1 - 3.9e-12 45.8 0.0 6.6e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF169 PF02596.15 EDP44432.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised ArCR, COG2043 YtxH PF12732.7 EDP44433.1 - 1.5e-05 25.4 15.4 0.012 16.1 3.5 3.6 2 2 1 3 3 3 2 YtxH-like protein DUF883 PF05957.13 EDP44433.1 - 0.00047 20.7 10.7 0.06 14.0 3.7 3.2 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF883) SH3BP5 PF05276.14 EDP44433.1 - 0.0012 18.7 10.4 0.012 15.4 10.0 1.9 1 1 1 2 2 2 1 SH3 domain-binding protein 5 (SH3BP5) Apolipoprotein PF01442.18 EDP44433.1 - 0.0015 18.5 10.6 0.0037 17.2 10.6 1.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Apo-CIII PF05778.12 EDP44433.1 - 0.0024 17.5 5.1 0.065 12.9 0.0 3.5 2 1 0 3 3 3 1 Apolipoprotein CIII (Apo-CIII) ApoLp-III PF07464.11 EDP44433.1 - 0.017 15.3 13.9 0.037 14.1 12.3 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.15 EDP44433.1 - 0.055 13.0 5.7 0.058 13.0 5.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2000 PF09391.10 EDP44433.1 - 0.075 12.9 0.7 0.12 12.3 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2000) NIBRIN_BRCT_II PF16508.5 EDP44433.1 - 0.14 12.5 2.5 0.18 12.2 0.7 2.0 1 1 1 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein Prominin PF05478.11 EDP44433.1 - 0.16 9.9 4.6 0.38 8.7 4.6 1.4 1 1 0 1 1 1 0 Prominin DUF2959 PF11172.8 EDP44433.1 - 0.2 11.8 6.6 0.35 11.0 6.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) ApoA-II PF04711.13 EDP44433.1 - 0.22 11.7 7.3 0.088 13.0 2.4 2.7 2 1 1 3 3 3 0 Apolipoprotein A-II (ApoA-II) DUF2563 PF10817.8 EDP44433.1 - 0.26 11.9 6.6 1.2 9.7 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2563) HSP9_HSP12 PF04119.12 EDP44433.1 - 0.36 11.3 9.6 1 9.8 0.5 4.0 2 2 3 5 5 5 0 Heat shock protein 9/12 Tape_meas_lam_C PF09718.10 EDP44433.1 - 0.39 10.9 14.4 5 7.3 1.4 3.6 3 1 1 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Atg14 PF10186.9 EDP44433.1 - 0.48 9.5 4.6 0.53 9.3 4.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PIN_8 PF18476.1 EDP44433.1 - 0.48 10.2 5.5 0.81 9.5 5.4 1.5 1 1 0 1 1 1 0 PIN like domain DUF2894 PF11445.8 EDP44433.1 - 1 9.8 8.3 2.7 8.4 8.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) V-ATPase_G_2 PF16999.5 EDP44433.1 - 1 9.8 14.4 26 5.3 11.9 3.2 2 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Muted PF14942.6 EDP44433.1 - 1.3 9.4 7.9 3.5 8.0 8.0 1.7 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Fib_alpha PF08702.10 EDP44433.1 - 1.5 9.0 5.7 0.42 10.8 1.3 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ATP-synt_B PF00430.18 EDP44433.1 - 2.7 8.1 18.2 0.64 10.1 9.9 2.5 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) ZYG-11_interact PF05884.12 EDP44433.1 - 3.7 6.9 4.9 4.1 6.7 4.0 1.6 1 1 0 1 1 1 0 Interactor of ZYG-11 Chorismate_bind PF00425.18 EDP44434.1 - 1.9e-76 257.0 0.0 2.7e-76 256.6 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EDP44434.1 - 9.9e-08 32.3 0.0 6.5e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Pro_isomerase PF00160.21 EDP44435.1 - 0.011 16.0 0.0 0.067 13.5 0.0 1.9 1 1 0 1 1 1 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF498 PF04430.14 EDP44436.1 - 4e-17 62.3 0.0 8.7e-17 61.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) FlaF PF07309.11 EDP44436.1 - 0.17 11.9 0.0 0.21 11.6 0.0 1.1 1 0 0 1 1 1 0 Flagellar protein FlaF Nop52 PF05997.12 EDP44437.1 - 0.013 15.3 0.1 0.016 15.0 0.1 1.2 1 0 0 1 1 1 0 Nucleolar protein,Nop52 RNA_pol_A_bac PF01000.26 EDP44438.1 - 3.2e-18 66.1 0.0 1.1e-17 64.4 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EDP44438.1 - 1e-06 28.0 0.0 1.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF1752 PF08550.10 EDP44439.1 - 3.8e-11 42.6 4.5 3.8e-11 42.6 4.5 1.8 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) EMC1_C PF07774.13 EDP44441.1 - 3.6e-55 186.9 0.0 6.6e-55 186.1 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EDP44441.1 - 0.017 14.7 2.2 0.044 13.4 0.3 2.5 3 0 0 3 3 3 0 PQQ-like domain Cofilin_ADF PF00241.20 EDP44442.1 - 3.8e-22 78.4 0.0 4.6e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein F-box-like PF12937.7 EDP44443.1 - 2.2e-08 33.8 0.3 5.6e-08 32.6 0.3 1.7 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 EDP44443.1 - 9.7e-08 32.6 1.0 0.067 14.1 0.0 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat F-box PF00646.33 EDP44443.1 - 8.7e-06 25.5 0.1 2.2e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain UIM PF02809.20 EDP44443.1 - 0.034 14.0 10.6 0.22 11.5 2.4 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif Noc2 PF03715.13 EDP44444.1 - 3.5e-111 371.2 0.3 5.3e-111 370.6 0.3 1.2 1 0 0 1 1 1 1 Noc2p family BUD22 PF09073.10 EDP44444.1 - 1.8 7.8 23.0 2.9 7.2 23.0 1.2 1 0 0 1 1 1 0 BUD22 UCH PF00443.29 EDP44445.1 - 5.6e-44 150.6 0.0 6.9e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP44445.1 - 9.4e-13 48.4 0.8 9.4e-11 41.9 0.8 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EDP44445.1 - 0.043 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family zf-H2C2_2 PF13465.6 EDP44446.1 - 3e-07 30.6 3.8 3e-07 30.6 3.8 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EDP44446.1 - 5.8e-07 29.6 15.8 0.00039 20.7 0.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP44446.1 - 0.00037 21.1 14.0 0.025 15.4 0.7 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 EDP44446.1 - 0.0065 16.9 3.6 0.13 12.7 0.5 2.4 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 EDP44446.1 - 0.056 13.5 0.5 0.056 13.5 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger CUE PF02845.16 EDP44447.1 - 8.5e-08 31.8 0.0 1.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain DUF3697 PF12478.8 EDP44447.1 - 2.3e-06 27.6 0.3 7.1e-06 26.0 0.3 1.9 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 SpoIIP PF07454.11 EDP44447.1 - 0.11 12.0 5.6 0.19 11.1 5.6 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 EDP44447.1 - 0.15 11.8 2.8 0.25 11.1 2.8 1.2 1 0 0 1 1 1 0 Connexin PAT1 PF09770.9 EDP44447.1 - 0.83 7.8 24.3 1.5 7.0 24.3 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim54 PF11711.8 EDP44447.1 - 1.1 8.0 12.4 0.14 10.9 8.2 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 eIF-3_zeta PF05091.12 EDP44447.1 - 1.2 8.0 11.4 2 7.3 11.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4770 PF15994.5 EDP44447.1 - 1.4 9.2 13.9 2.7 8.2 13.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) EPL1 PF10513.9 EDP44447.1 - 1.5 9.2 12.4 0.23 11.8 7.9 1.9 2 0 0 2 2 2 0 Enhancer of polycomb-like Sec62 PF03839.16 EDP44447.1 - 1.7 8.1 6.0 3.1 7.2 6.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 SLC12 PF03522.15 EDP44447.1 - 3.4 6.6 8.4 5.8 5.8 8.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Lin-8 PF03353.15 EDP44447.1 - 3.5 7.1 14.8 0.9 9.0 11.3 1.8 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Zip PF02535.22 EDP44447.1 - 4.1 6.5 5.5 3.4 6.8 3.8 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Plasmodium_Vir PF05795.11 EDP44447.1 - 7.4 5.9 6.4 3.3 7.0 2.0 2.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.12 EDP44447.1 - 9 6.0 12.8 1.2 8.9 8.4 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DSPc PF00782.20 EDP44448.1 - 1.8e-29 102.2 0.0 3.7e-29 101.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 EDP44448.1 - 0.0054 16.3 0.0 0.0098 15.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Rhodanese PF00581.20 EDP44448.1 - 0.048 14.2 0.1 0.51 10.9 0.0 2.6 3 0 0 3 3 3 0 Rhodanese-like domain Y_phosphatase3 PF13350.6 EDP44448.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family TFIIA PF03153.13 EDP44448.1 - 0.075 13.0 10.0 0.11 12.5 10.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit B-block_TFIIIC PF04182.12 EDP44449.1 - 2e-05 24.6 0.0 4.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 EDP44449.1 - 0.00065 19.5 2.3 0.0094 15.8 0.1 4.0 4 0 0 4 4 4 1 MarR family Semialdhyde_dh PF01118.24 EDP44449.1 - 0.029 14.8 0.0 0.076 13.4 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain HTH_20 PF12840.7 EDP44449.1 - 0.029 14.4 0.0 1.2 9.2 0.0 3.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_IclR PF09339.10 EDP44449.1 - 0.056 13.3 0.7 4.6 7.1 0.0 3.8 4 0 0 4 4 4 0 IclR helix-turn-helix domain HTH_micro PF17007.5 EDP44449.1 - 0.19 10.5 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 HTH-like PAP_assoc PF03828.19 EDP44450.1 - 1.9e-17 63.2 0.1 3.7e-17 62.3 0.1 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EDP44450.1 - 5.1e-06 26.7 0.0 1.2e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EDP44450.1 - 0.058 13.5 0.0 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase FAM199X PF15814.5 EDP44450.1 - 0.56 9.2 4.1 1 8.4 4.1 1.4 1 0 0 1 1 1 0 Protein family FAM199X Pan3_PK PF18101.1 EDP44451.1 - 4.4e-52 175.7 0.1 6.2e-52 175.2 0.1 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain CTU2 PF10288.9 EDP44452.1 - 1.3e-14 54.4 0.0 4.7e-14 52.6 0.0 2.0 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 Pkinase PF00069.25 EDP44453.1 - 1.6e-68 231.0 0.0 2.6e-68 230.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44453.1 - 5e-39 134.1 0.0 1.2e-38 132.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44453.1 - 1.1e-07 31.4 0.0 1.8e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP44453.1 - 0.00075 19.5 0.0 0.0021 18.0 0.0 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDP44453.1 - 0.0015 18.2 0.2 0.0038 16.8 0.2 1.6 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EDP44453.1 - 0.0052 15.8 0.0 0.0084 15.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EDP44453.1 - 0.051 12.4 0.5 0.093 11.5 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase KA1 PF02149.19 EDP44454.1 - 9.1e-09 35.0 0.1 1.4e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 Kinase associated domain 1 OrfB_IS605 PF01385.19 EDP44454.1 - 0.26 11.5 2.8 0.5 10.6 1.7 2.0 2 0 0 2 2 2 0 Probable transposase Mito_carr PF00153.27 EDP44455.1 - 5.3e-41 138.4 0.3 8e-20 70.6 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Mito_carr PF00153.27 EDP44456.1 - 2.2e-21 75.6 0.0 2.5e-21 75.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Aa_trans PF01490.18 EDP44457.1 - 7.4e-21 74.3 38.0 1.3e-20 73.5 38.0 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Sec1 PF00995.23 EDP44458.1 - 6.7e-126 421.8 0.0 7.7e-126 421.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Abhydrolase_4 PF08386.10 EDP44458.1 - 0.14 12.2 1.0 5.7 7.1 0.1 2.9 2 1 1 3 3 3 0 TAP-like protein Pex14_N PF04695.13 EDP44459.1 - 1.3e-26 94.1 0.4 1.3e-26 94.1 0.4 3.7 2 2 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Nup88 PF10168.9 EDP44459.1 - 0.00025 19.0 3.3 0.00031 18.7 3.3 1.0 1 0 0 1 1 1 1 Nuclear pore component ERM PF00769.19 EDP44459.1 - 0.00056 19.8 2.0 0.00075 19.4 2.0 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 EDP44459.1 - 0.0014 18.2 6.6 0.0019 17.7 6.6 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 FUSC PF04632.12 EDP44459.1 - 0.0043 15.6 2.2 0.22 10.0 2.2 2.0 1 1 1 2 2 2 2 Fusaric acid resistance protein family STAT_alpha PF01017.20 EDP44459.1 - 0.0063 16.4 4.3 0.0096 15.8 4.3 1.3 1 0 0 1 1 1 1 STAT protein, all-alpha domain Mce4_CUP1 PF11887.8 EDP44459.1 - 0.014 14.9 0.4 0.023 14.2 0.4 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative AAA_13 PF13166.6 EDP44459.1 - 0.03 13.0 1.5 0.041 12.6 1.5 1.0 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.9 EDP44459.1 - 0.056 12.5 2.7 0.075 12.1 2.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC-like PF12805.7 EDP44459.1 - 0.074 12.1 0.1 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS Spc7 PF08317.11 EDP44459.1 - 0.088 11.7 6.7 0.13 11.1 6.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1043 PF06295.12 EDP44459.1 - 0.12 12.4 3.6 1.6 8.7 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) PI3K_P85_iSH2 PF16454.5 EDP44459.1 - 0.15 11.7 4.2 0.32 10.6 4.2 1.6 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain KxDL PF10241.9 EDP44459.1 - 0.17 12.2 2.3 0.33 11.3 2.2 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein DUF3584 PF12128.8 EDP44459.1 - 0.43 8.0 8.0 0.54 7.7 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 EDP44459.1 - 0.46 10.6 6.2 0.67 10.0 6.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus COG2 PF06148.11 EDP44459.1 - 0.61 10.2 4.5 4.9 7.2 1.1 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 MIP-T3_C PF17749.1 EDP44459.1 - 0.68 9.9 6.6 7.6 6.5 0.6 2.2 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DLP_helical PF18709.1 EDP44459.1 - 0.73 9.0 5.6 2.2 7.4 5.7 1.7 1 1 0 1 1 1 0 Dynamin-like helical domain TBCC_N PF16752.5 EDP44459.1 - 0.76 10.2 8.2 1.8 9.1 8.2 1.6 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain FlgN PF05130.12 EDP44459.1 - 0.82 10.2 10.3 1.3 9.5 9.8 1.5 1 1 0 1 1 1 0 FlgN protein TMPIT PF07851.13 EDP44459.1 - 1 8.6 4.8 1.4 8.1 4.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.14 EDP44459.1 - 1.2 9.5 7.3 2.8 8.3 7.3 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 EDP44459.1 - 1.7 9.1 8.4 4 7.9 8.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) SlyX PF04102.12 EDP44459.1 - 2.2 8.9 8.1 2.2 8.9 3.5 2.7 2 1 1 3 3 2 0 SlyX HIP1_clath_bdg PF16515.5 EDP44459.1 - 4.1 8.1 11.1 5.7 7.6 7.5 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RNA_pol_L_2 PF13656.6 EDP44460.1 - 2.7e-28 97.5 0.0 3.5e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EDP44460.1 - 1.9e-11 43.2 0.0 2.8e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DEC-1_C PF04626.13 EDP44460.1 - 0.55 10.6 2.6 0.88 10.0 2.6 1.3 1 0 0 1 1 1 0 Dec-1 protein, C terminal region RRM_1 PF00076.22 EDP44461.1 - 1.2e-35 121.2 0.0 7.9e-17 60.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP44461.1 - 5.4e-13 48.9 0.1 3.6e-05 23.8 0.0 2.8 2 2 0 2 2 2 2 RNA recognition motif Lipoprotein_18 PF06804.11 EDP44461.1 - 0.0039 16.3 0.0 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 NlpB/DapX lipoprotein Nup35_RRM_2 PF14605.6 EDP44461.1 - 0.1 12.6 0.2 1.4 8.9 0.0 2.5 2 1 1 3 3 3 0 Nup53/35/40-type RNA recognition motif Rib_recp_KP_reg PF05104.12 EDP44462.1 - 5.7 8.0 12.4 8.3 7.4 12.4 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Membr_traf_MHD PF10540.9 EDP44463.1 - 2.9e-16 60.0 0.9 2.5e-07 31.0 0.3 3.0 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EDP44463.1 - 1.1e-05 25.7 0.0 2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EDP44463.1 - 0.0013 17.4 0.3 0.0028 16.3 0.3 1.4 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) Rft-1 PF04506.13 EDP44464.1 - 7.5e-83 279.0 0.0 8.7e-83 278.8 0.0 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EDP44464.1 - 0.003 16.8 2.1 0.0037 16.5 0.0 2.2 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein TetR_C_11 PF16859.5 EDP44465.1 - 0.39 11.0 4.5 2.8 8.3 0.0 3.8 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain Mid1 PF12929.7 EDP44466.1 - 8.4e-79 265.7 3.6 6.1e-77 259.6 3.6 2.0 1 1 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component fn3 PF00041.21 EDP44466.1 - 0.0013 19.0 0.1 0.0033 17.7 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Fz PF01392.22 EDP44466.1 - 0.0035 18.0 6.6 0.037 14.6 1.5 2.6 2 0 0 2 2 2 2 Fz domain Pkinase PF00069.25 EDP44467.1 - 6.2e-66 222.5 0.0 7.6e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44467.1 - 4.8e-32 111.3 0.0 6.2e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP44467.1 - 1.5e-05 24.2 0.0 2.1e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EDP44467.1 - 0.00056 19.3 0.0 0.0016 17.8 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP44467.1 - 0.0015 18.5 0.0 0.0034 17.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP44467.1 - 0.012 14.9 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EDP44467.1 - 0.028 14.0 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EDP44467.1 - 0.047 13.3 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family FCH PF00611.23 EDP44468.1 - 9.7e-10 38.6 0.0 2.8e-09 37.1 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain muHD PF10291.9 EDP44469.1 - 6.1e-18 65.2 0.0 8e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain HIG_1_N PF04588.13 EDP44470.1 - 0.04 14.1 3.4 0.064 13.5 3.4 1.4 1 0 0 1 1 1 0 Hypoxia induced protein conserved region GAS PF13851.6 EDP44470.1 - 0.068 12.5 0.8 0.089 12.1 0.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF444 PF04285.12 EDP44470.1 - 0.21 10.6 3.0 0.25 10.4 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF444) DUF3408 PF11888.8 EDP44470.1 - 0.9 9.7 4.4 1.4 9.0 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3408) DUF4407 PF14362.6 EDP44470.1 - 6.5 6.0 8.8 8.9 5.6 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) VHS PF00790.19 EDP44471.1 - 0.0016 18.3 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 VHS domain Pkinase PF00069.25 EDP44472.1 - 7.5e-30 104.2 0.0 1.2e-29 103.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44472.1 - 5.7e-14 52.0 0.0 8.3e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44472.1 - 4.8e-05 22.8 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDP44472.1 - 0.0028 17.0 0.0 0.0059 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP44472.1 - 0.0042 17.0 0.0 0.011 15.7 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDP44472.1 - 0.02 14.5 0.0 0.059 13.0 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FSA_C PF10479.9 EDP44472.1 - 0.034 12.3 6.4 0.047 11.8 6.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Choline_kinase PF01633.20 EDP44472.1 - 0.17 11.5 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase SPESP1 PF15754.5 EDP44472.1 - 0.27 10.4 6.5 1.8 7.7 8.1 1.5 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 Pkinase_fungal PF17667.1 EDP44472.1 - 0.4 9.4 2.3 1.2 7.9 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase AJAP1_PANP_C PF15298.6 EDP44472.1 - 1.5 9.0 13.9 2.7 8.2 13.9 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Dicty_REP PF05086.12 EDP44472.1 - 2.4 6.0 13.4 3.5 5.5 13.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Med3 PF11593.8 EDP44472.1 - 2.7 7.1 14.0 5 6.2 14.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PIG-L PF02585.17 EDP44473.1 - 7.2e-24 84.9 0.0 1e-23 84.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase PEMT PF04191.13 EDP44474.1 - 4.6e-33 113.8 4.1 1.1e-32 112.5 4.1 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase EI24 PF07264.11 EDP44474.1 - 0.0051 17.1 1.9 0.032 14.5 0.2 2.1 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Pannexin_like PF12534.8 EDP44474.1 - 0.16 11.0 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF3810 PF12725.7 EDP44474.1 - 0.26 10.6 0.6 3.1 7.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) PCI PF01399.27 EDP44475.1 - 4.5e-15 56.1 0.0 2e-14 54.0 0.0 2.1 3 0 0 3 3 3 1 PCI domain DUF3562 PF12085.8 EDP44475.1 - 0.085 12.5 0.5 0.93 9.2 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3562) ALO PF04030.14 EDP44476.1 - 4.5e-54 184.0 0.7 2.9e-53 181.3 0.2 2.1 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EDP44476.1 - 3.5e-18 65.7 0.0 7.9e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Thioredoxin PF00085.20 EDP44477.1 - 5.7e-55 183.6 0.1 1.8e-28 98.5 0.0 4.1 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EDP44477.1 - 9.2e-38 130.0 0.2 5.7e-29 101.3 0.1 3.3 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EDP44477.1 - 1.7e-09 37.4 0.0 0.00051 19.5 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EDP44477.1 - 5.1e-07 29.9 0.1 1 9.8 0.0 4.7 5 1 1 6 6 6 2 Thioredoxin-like AhpC-TSA PF00578.21 EDP44477.1 - 1.2e-06 28.4 0.4 0.5 10.3 0.1 3.9 4 0 0 4 4 4 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EDP44477.1 - 3e-06 27.3 0.0 0.35 11.1 0.0 3.6 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EDP44477.1 - 4.8e-05 23.8 1.9 0.24 11.9 0.1 4.1 3 2 1 4 4 4 2 Thioredoxin-like domain Redoxin PF08534.10 EDP44477.1 - 0.017 14.8 1.0 5.7 6.7 0.0 3.4 3 0 0 3 3 3 0 Redoxin Thioredoxin_3 PF13192.6 EDP44477.1 - 0.03 14.4 0.1 4 7.6 0.0 2.8 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_9 PF14595.6 EDP44477.1 - 0.03 14.1 0.0 9.9 5.9 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 EDP44477.1 - 0.13 12.4 0.4 3.9 7.6 0.1 2.6 2 1 0 2 2 2 0 Thioredoxin Calsequestrin PF01216.17 EDP44477.1 - 0.16 11.0 1.8 0.14 11.1 0.5 1.5 2 0 0 2 2 2 0 Calsequestrin RhoGEF PF00621.20 EDP44478.1 - 6.5e-38 130.8 0.6 1.1e-37 130.1 0.6 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 EDP44478.1 - 4.9e-34 117.2 0.0 9.1e-34 116.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 EDP44478.1 - 3.2e-24 85.0 0.0 6.2e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 EDP44478.1 - 7.8e-09 35.4 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 EDP44478.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.7 1 1 0 1 1 1 0 PH domain SL4P PF17618.2 EDP44478.1 - 0.13 12.3 0.0 0.44 10.6 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein Gp_dh_C PF02800.20 EDP44479.1 - 1.7e-71 239.0 0.0 2.4e-71 238.4 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EDP44479.1 - 2.3e-38 130.6 0.0 5.2e-38 129.4 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EDP44479.1 - 0.12 12.6 0.0 0.4 10.8 0.0 1.9 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RNase_PH PF01138.21 EDP44480.1 - 2.8e-14 53.8 0.0 4.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 ABATE PF07336.11 EDP44480.1 - 0.023 15.3 0.2 4 8.1 0.0 2.1 2 0 0 2 2 2 0 Putative stress-induced transcription regulator RNase_PH_C PF03725.15 EDP44480.1 - 0.088 12.9 0.1 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 STE3 PF02076.15 EDP44482.1 - 1.7e-82 276.9 13.6 1.7e-82 276.9 13.6 1.4 2 0 0 2 2 2 1 Pheromone A receptor VWA_2 PF13519.6 EDP44483.1 - 6.8e-16 58.8 0.1 3e-15 56.8 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain UIM PF02809.20 EDP44483.1 - 3.3e-08 32.9 19.1 0.0023 17.7 1.6 4.5 4 0 0 4 4 4 3 Ubiquitin interaction motif VWA PF00092.28 EDP44483.1 - 0.00012 22.4 0.1 0.0002 21.7 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 EDP44483.1 - 0.0047 16.8 0.0 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like RAP80_UIM PF18282.1 EDP44483.1 - 0.13 12.1 0.1 0.13 12.1 0.1 3.6 4 0 0 4 4 4 0 RAP80 N-terminal ubiquitin interaction motif MSP1_C PF07462.11 EDP44483.1 - 9.7 4.8 8.3 2.9 6.5 4.8 1.7 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus CAF1 PF04857.20 EDP44484.1 - 5.2e-24 85.0 0.0 2.4e-12 46.7 0.0 2.3 2 1 0 2 2 2 2 CAF1 family ribonuclease RNase_H_2 PF13482.6 EDP44484.1 - 0.13 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 RNase_H superfamily UQ_con PF00179.26 EDP44485.1 - 1.4e-45 154.3 0.0 1.6e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDP44485.1 - 0.063 13.0 0.0 0.097 12.4 0.0 1.5 1 1 0 1 1 1 0 Prokaryotic E2 family B Alpha-amylase_C PF02806.18 EDP44486.1 - 0.015 15.8 0.0 0.017 15.6 0.0 1.1 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain GTP_EFTU PF00009.27 EDP44487.1 - 6.3e-29 100.9 2.1 6.3e-29 100.9 2.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EDP44487.1 - 1.6e-23 82.8 0.0 8.8e-23 80.4 0.0 2.1 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EDP44487.1 - 4.6e-07 30.1 0.2 0.0038 17.6 0.1 3.0 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP44487.1 - 5.5e-07 29.7 0.1 1.1e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDP44487.1 - 0.00018 21.5 0.1 0.081 12.8 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EDP44487.1 - 0.00067 19.2 0.0 0.0019 17.7 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EDP44487.1 - 0.0031 17.0 0.0 0.0061 16.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EDP44487.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EDP44487.1 - 0.014 14.8 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EDP44487.1 - 0.017 14.8 0.1 0.32 10.7 0.1 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 EDP44487.1 - 0.18 12.2 0.0 5.1 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Prefoldin PF02996.17 EDP44488.1 - 1.1e-29 102.7 0.2 1.5e-29 102.4 0.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Ribosomal_L28e PF01778.17 EDP44489.1 - 1.1e-30 106.8 0.3 1.3e-30 106.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family DUF3128 PF11326.8 EDP44491.1 - 1.4e-23 83.0 0.7 1.9e-23 82.6 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) PAS_7 PF12860.7 EDP44491.1 - 0.15 12.2 0.0 0.64 10.2 0.0 1.9 1 1 1 2 2 2 0 PAS fold RNA_pol_Rpb2_6 PF00562.28 EDP44492.1 - 4.5e-125 417.8 0.5 8e-125 416.9 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EDP44492.1 - 9.1e-58 195.1 0.1 1.3e-57 194.6 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EDP44492.1 - 9e-37 126.6 0.8 2.1e-36 125.4 0.8 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EDP44492.1 - 1.9e-30 105.1 0.2 4.6e-30 103.9 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EDP44492.1 - 1e-24 86.6 0.8 2.6e-24 85.3 0.8 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EDP44492.1 - 1.2e-20 73.5 0.1 3.4e-20 72.0 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EDP44492.1 - 3.5e-09 37.1 0.1 1e-08 35.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 NIF3 PF01784.18 EDP44493.1 - 8.9e-59 199.1 0.0 1.1e-58 198.7 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) DUF89 PF01937.19 EDP44494.1 - 6.9e-109 364.0 0.0 7.9e-109 363.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Bap31 PF05529.12 EDP44495.1 - 3.1e-18 65.9 0.6 3.1e-18 65.9 0.6 1.7 2 0 0 2 2 2 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EDP44495.1 - 5.9e-11 42.2 3.1 8.3e-11 41.7 3.1 1.3 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain CmlA_N PF18456.1 EDP44495.1 - 0.0042 16.4 0.3 0.0048 16.2 0.3 1.2 1 0 0 1 1 1 1 Diiron non-heme beta-hydroxylase N-terminal domain DUF3450 PF11932.8 EDP44495.1 - 0.015 14.6 2.1 0.019 14.3 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FliD_N PF02465.18 EDP44495.1 - 0.34 11.6 6.4 0.42 11.3 4.8 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus EMC3_TMCO1 PF01956.16 EDP44495.1 - 0.44 10.3 2.5 0.81 9.4 2.5 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DivIC PF04977.15 EDP44495.1 - 0.54 10.1 4.8 1 9.2 4.8 1.5 1 0 0 1 1 1 0 Septum formation initiator MT-A70 PF05063.14 EDP44496.1 - 2.8e-39 134.8 0.0 3.9e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 MT-A70 GAIN_A PF18619.1 EDP44496.1 - 0.042 14.1 0.1 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A Mg_trans_NIPA PF05653.14 EDP44497.1 - 4.5e-60 203.3 9.6 6.1e-60 202.8 9.6 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EDP44497.1 - 4.8e-06 26.8 24.3 0.00057 20.1 3.7 3.0 2 1 0 2 2 2 2 EamA-like transporter family Oxidored_q6 PF01058.22 EDP44497.1 - 0.18 11.6 0.3 0.78 9.6 0.0 2.0 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase, 20 Kd subunit TssN PF17555.2 EDP44497.1 - 5.7 6.2 8.1 9.6 5.5 8.1 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN Pyr_redox_2 PF07992.14 EDP44498.1 - 4.7e-67 226.3 5.8 4.7e-67 226.3 5.8 1.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDP44498.1 - 1.7e-42 144.1 0.2 5.6e-42 142.5 0.2 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDP44498.1 - 3.6e-20 72.3 10.7 4.8e-19 68.7 0.8 3.5 5 0 0 5 5 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EDP44498.1 - 3.6e-13 49.7 9.8 5e-11 42.6 0.1 3.1 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDP44498.1 - 2e-12 47.0 5.6 8.5e-10 38.4 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDP44498.1 - 2.3e-11 43.4 2.8 2.9e-09 36.5 0.6 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDP44498.1 - 7.8e-11 42.1 1.7 0.0001 22.4 0.3 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EDP44498.1 - 1.2e-08 34.2 12.2 0.00014 20.7 1.0 4.2 4 0 0 4 4 4 3 HI0933-like protein FAD_binding_3 PF01494.19 EDP44498.1 - 2.2e-07 30.5 10.8 0.02 14.1 1.2 3.4 3 0 0 3 3 3 3 FAD binding domain AlaDh_PNT_C PF01262.21 EDP44498.1 - 5e-07 29.2 3.4 0.0017 17.7 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EDP44498.1 - 2.3e-06 26.9 2.1 2.3e-06 26.9 2.1 3.4 2 1 1 3 3 3 1 FAD binding domain K_oxygenase PF13434.6 EDP44498.1 - 4.1e-05 22.9 1.3 0.063 12.4 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EDP44498.1 - 0.00014 21.2 8.9 0.0019 17.5 1.2 2.6 1 1 1 2 2 2 2 Thi4 family Amino_oxidase PF01593.24 EDP44498.1 - 0.0011 18.3 0.1 0.0033 16.8 0.1 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EDP44498.1 - 0.0023 17.6 14.0 2.6 7.6 0.8 3.8 3 1 1 4 4 4 3 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EDP44498.1 - 0.065 12.3 3.6 1.3 8.0 0.6 2.7 2 1 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EDP44498.1 - 0.16 11.8 1.3 0.32 10.8 0.3 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EDP44498.1 - 0.41 11.1 2.6 1.9 9.0 0.1 2.9 3 0 0 3 3 3 0 Putative NAD(P)-binding Metallophos PF00149.28 EDP44499.1 - 2.2e-34 119.8 0.0 3.2e-34 119.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EDP44499.1 - 0.0099 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Complex1_LYR PF05347.15 EDP44500.1 - 4.4e-08 33.1 0.1 7.5e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDP44500.1 - 2.4e-05 25.0 0.1 3.3e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like RRM_1 PF00076.22 EDP44501.1 - 1e-13 50.9 0.0 1.5e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP44501.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif CTP_transf_like PF01467.26 EDP44502.1 - 2.2e-26 92.7 0.0 3.1e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like LIM PF00412.22 EDP44503.1 - 9.4e-15 54.6 18.3 4.8e-08 33.1 4.3 2.4 2 1 0 2 2 2 2 LIM domain zf-trcl PF13451.6 EDP44503.1 - 0.022 14.7 3.5 0.022 14.7 3.5 2.8 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-RING_7 PF02591.15 EDP44503.1 - 3.9 7.7 10.2 8.2 6.7 0.1 2.9 3 0 0 3 3 3 0 C4-type zinc ribbon domain Rpn3_C PF08375.11 EDP44505.1 - 1.9e-25 89.0 0.9 5e-25 87.7 0.9 1.8 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EDP44505.1 - 8.1e-24 84.2 0.4 3.2e-23 82.2 0.4 2.1 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EDP44505.1 - 0.068 13.3 0.1 0.85 9.9 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TLV_coat PF00429.19 EDP44505.1 - 0.082 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) RRM_1 PF00076.22 EDP44506.1 - 1.1e-73 243.1 0.0 1.1e-17 63.6 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP44506.1 - 0.00012 22.0 0.0 0.47 10.5 0.0 3.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EDP44506.1 - 0.00016 21.7 0.0 0.87 9.7 0.0 4.1 5 0 0 5 5 5 1 RNA recognition motif RRM_2 PF04059.12 EDP44506.1 - 0.00055 20.1 0.0 0.094 12.9 0.0 3.5 4 0 0 4 4 4 1 RNA recognition motif 2 RRM_occluded PF16842.5 EDP44506.1 - 0.0011 18.8 0.0 6.7 6.6 0.0 4.6 5 0 0 5 5 5 1 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EDP44506.1 - 0.0046 16.8 0.4 3.6 7.4 0.0 4.8 5 1 1 6 6 6 1 Rrp7 RRM-like N-terminal domain RAB3GAP2_C PF14656.6 EDP44506.1 - 3.2 5.9 7.9 0.15 10.2 0.9 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit C-terminus MitMem_reg PF13012.6 EDP44507.1 - 1.6 9.2 4.6 2.6 8.5 0.0 3.2 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Mito_carr PF00153.27 EDP44508.1 - 4.4e-49 164.4 1.4 5.2e-23 80.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein HMG_box PF00505.19 EDP44509.1 - 1.7e-18 66.8 0.6 2.6e-18 66.2 0.6 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EDP44509.1 - 7.4e-15 55.3 1.8 1.1e-14 54.8 1.8 1.3 1 0 0 1 1 1 1 HMG-box domain LSM PF01423.22 EDP44510.1 - 2.6e-14 52.7 0.1 3.2e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EDP44510.1 - 0.025 14.7 0.0 0.034 14.3 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Proteasome PF00227.26 EDP44511.1 - 3.9e-60 202.6 0.1 5.2e-60 202.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDP44511.1 - 1.9e-14 53.0 0.2 5e-14 51.6 0.2 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GST_N PF02798.20 EDP44512.1 - 1.4e-15 57.3 0.0 1.7e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDP44512.1 - 3e-12 46.8 0.0 3.5e-12 46.5 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EDP44512.1 - 4.6e-06 26.8 0.0 5.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain EF1G PF00647.19 EDP44513.1 - 1.8e-45 153.3 0.2 4.4e-45 152.1 0.0 1.7 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C_2 PF13410.6 EDP44513.1 - 1.5e-08 34.5 0.0 2.9e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP44513.1 - 1.8e-08 34.5 0.0 4.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDP44513.1 - 2.6e-08 33.9 0.2 1.1e-07 31.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Flavodoxin_1 PF00258.25 EDP44514.1 - 2.5e-32 112.0 0.0 3.6e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EDP44514.1 - 0.00026 20.6 0.0 0.00039 20.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_1 PF00667.20 EDP44515.1 - 1.5e-18 67.2 0.1 3e-15 56.4 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_1 PF00175.21 EDP44515.1 - 2.2e-11 44.4 0.0 3.5e-10 40.5 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain COX6C PF02937.15 EDP44516.1 - 0.0022 18.1 0.0 0.0025 17.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Peptidase_M24 PF00557.24 EDP44517.1 - 1.3e-39 136.1 0.0 1.7e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Pantoate_ligase PF02569.15 EDP44518.1 - 2.6e-86 289.1 0.0 3e-86 288.9 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ras PF00071.22 EDP44519.1 - 4.1e-60 202.1 0.1 5.2e-60 201.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP44519.1 - 1.9e-36 124.9 0.0 2.7e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP44519.1 - 5.8e-12 45.4 0.0 6.6e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDP44519.1 - 1.8e-05 24.8 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EDP44519.1 - 3.2e-05 23.9 0.0 0.02 14.8 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EDP44519.1 - 3.5e-05 23.4 0.0 5.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EDP44519.1 - 8.3e-05 22.1 0.0 0.0001 21.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EDP44519.1 - 0.047 14.1 0.0 0.065 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 EDP44519.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain RRM_1 PF00076.22 EDP44520.1 - 4.2e-13 48.9 0.0 1.5e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EDP44520.1 - 0.11 12.6 0.5 19 5.3 0.1 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Myb_DNA-binding PF00249.31 EDP44521.1 - 2.9e-09 37.0 0.0 4.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP44521.1 - 9.6e-08 32.2 0.0 1.8e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain SNF2_N PF00176.23 EDP44522.1 - 1.3e-46 158.9 0.0 2e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP44522.1 - 1.1e-07 32.2 0.0 5.6e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EDP44522.1 - 8.6e-07 28.7 14.4 1.2e-06 28.2 13.1 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP44522.1 - 3.9e-06 26.6 10.8 9.1e-06 25.4 10.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDP44522.1 - 8.4e-06 25.6 11.3 2.3e-05 24.2 11.3 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EDP44522.1 - 0.0002 21.1 15.3 0.00023 21.0 13.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP44522.1 - 0.00022 21.5 14.0 0.0007 19.9 14.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-UDP PF14569.6 EDP44522.1 - 0.00089 19.3 2.7 0.0024 17.9 2.7 1.7 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_5 PF14634.6 EDP44522.1 - 0.0077 16.2 13.5 0.019 14.9 13.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Helicase_C_4 PF13871.6 EDP44522.1 - 0.049 13.3 0.7 0.11 12.2 0.2 1.8 2 0 0 2 2 2 0 C-terminal domain on Strawberry notch homologue zf-RING_4 PF14570.6 EDP44522.1 - 0.42 10.5 8.6 1 9.2 8.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.11 EDP44522.1 - 0.7 9.8 2.7 2 8.4 2.7 1.7 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.6 EDP44522.1 - 0.93 9.4 5.6 2.7 7.9 5.6 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 EDP44522.1 - 1 9.0 10.6 3.1 7.5 10.6 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EDP44522.1 - 4.6 7.5 11.1 11 6.3 11.1 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EDP44522.1 - 8.3 6.5 11.1 17 5.6 10.2 2.0 2 0 0 2 2 2 0 RING-type zinc-finger COX5A PF02284.16 EDP44523.1 - 2e-40 137.0 0.1 2.2e-40 136.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Oxidored-like PF09791.9 EDP44524.1 - 2.3e-17 62.4 2.8 3.8e-17 61.7 2.8 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal SUKH-4 PF14435.6 EDP44524.1 - 0.037 14.1 0.4 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 SUKH-4 immunity protein DUF5522 PF17653.1 EDP44524.1 - 0.042 13.8 2.2 0.08 12.9 2.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5522) ABC1 PF03109.16 EDP44525.1 - 7.5e-29 100.3 0.0 1.2e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EDP44525.1 - 0.045 13.1 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain WaaY PF06176.11 EDP44525.1 - 0.25 10.9 0.0 0.39 10.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Actin PF00022.19 EDP44526.1 - 2.3e-111 372.3 0.0 1.9e-110 369.3 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EDP44526.1 - 0.00066 18.6 0.0 0.0049 15.7 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein Plus-3 PF03126.18 EDP44527.1 - 8.9e-20 71.2 0.2 3.6e-19 69.3 0.0 2.1 3 0 0 3 3 3 1 Plus-3 domain TPR_2 PF07719.17 EDP44529.1 - 3e-09 36.3 3.9 0.00061 19.7 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44529.1 - 1.1e-08 35.4 7.5 0.00072 20.0 1.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44529.1 - 8.6e-08 31.7 2.6 0.00021 21.0 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44529.1 - 1.4e-05 25.6 5.1 0.0052 17.4 1.9 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44529.1 - 1.8e-05 25.2 6.0 0.022 15.5 0.1 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44529.1 - 6.6e-05 23.1 4.9 0.0032 17.7 0.9 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44529.1 - 0.00069 19.3 1.2 0.0019 17.8 0.1 2.0 1 1 1 2 2 2 1 TPR repeat TPR_6 PF13174.6 EDP44529.1 - 0.00079 19.9 1.8 0.54 11.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44529.1 - 0.0014 18.6 0.8 4.7 7.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44529.1 - 0.0016 18.6 0.8 0.54 10.5 0.1 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EDP44529.1 - 0.0048 17.2 1.1 0.052 13.9 0.2 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EDP44529.1 - 0.011 14.9 3.7 0.024 13.8 3.7 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44529.1 - 0.04 14.0 2.4 0.98 9.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EDP44529.1 - 0.053 13.6 2.9 5 7.3 0.8 2.6 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EDP44529.1 - 0.16 11.9 3.8 6.3 6.8 1.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDP44529.1 - 0.24 11.6 5.0 0.46 10.7 2.6 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EDP44530.1 - 1.7e-23 82.5 1.8 8.9e-23 80.2 0.4 2.5 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 EDP44530.1 - 3.1e-16 58.4 2.1 1.6e-06 27.7 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44530.1 - 2.1e-14 52.4 7.0 0.00093 19.1 0.0 5.0 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44530.1 - 1.1e-07 31.5 6.8 0.055 13.7 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44530.1 - 2.8e-07 30.9 17.2 0.00013 22.4 4.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44530.1 - 3.8e-07 30.3 12.4 0.0002 21.6 0.8 4.8 3 2 1 4 4 4 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 EDP44530.1 - 4.4e-05 22.8 0.2 0.089 12.3 0.2 2.8 2 0 0 2 2 2 2 SHNi-TPR TPR_16 PF13432.6 EDP44530.1 - 5.3e-05 23.8 15.4 0.03 15.0 0.1 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44530.1 - 6.9e-05 22.6 7.7 0.15 12.2 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44530.1 - 0.00014 22.0 6.4 2.3 8.8 0.1 5.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EDP44530.1 - 0.00017 21.2 9.8 4 7.2 0.1 4.7 4 1 1 5 5 5 2 TPR repeat TPR_9 PF13371.6 EDP44530.1 - 0.00024 21.2 10.9 0.0024 18.0 1.3 3.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44530.1 - 0.00026 21.6 16.3 1.1 10.2 0.3 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44530.1 - 0.001 19.3 4.1 0.32 11.3 0.1 3.3 3 2 1 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF5344 PF17279.2 EDP44530.1 - 0.004 17.7 2.1 0.017 15.7 0.0 2.7 2 1 0 2 2 2 1 Family of unknown function (DUF5344) DDE_Tnp_IS240 PF13610.6 EDP44530.1 - 0.27 11.5 2.6 6.1 7.1 0.1 2.3 1 1 1 2 2 2 0 DDE domain Fis1_TPR_C PF14853.6 EDP44530.1 - 0.48 10.5 5.6 6 7.0 0.6 3.2 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EDP44530.1 - 0.64 10.0 14.6 2.2 8.3 0.7 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDP44530.1 - 5.4 8.0 7.0 9.5 7.2 0.2 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat WD40 PF00400.32 EDP44531.1 - 2.3e-38 129.5 16.8 4.5e-07 30.5 0.2 8.8 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44531.1 - 1e-14 54.6 0.7 0.33 11.3 0.0 7.0 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 EDP44531.1 - 1.6e-09 37.5 0.3 5.8e-09 35.7 0.3 2.1 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 EDP44531.1 - 1.3e-08 34.0 4.2 0.044 12.4 0.0 5.3 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 EDP44531.1 - 3.2e-07 30.0 0.0 7.4e-05 22.2 0.0 3.2 3 0 0 3 3 3 1 WD40-like domain DUF5046 PF16465.5 EDP44531.1 - 0.00028 20.4 0.1 0.00092 18.7 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5046) F-box PF00646.33 EDP44531.1 - 0.0062 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 F-box domain PQQ_3 PF13570.6 EDP44531.1 - 0.0091 16.5 7.7 13 6.4 0.1 5.2 5 0 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.6 EDP44531.1 - 0.019 14.6 5.8 0.12 11.9 0.6 2.6 1 1 1 2 2 2 0 PQQ-like domain F-box_5 PF18511.1 EDP44531.1 - 0.019 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 F-box Ctr PF04145.15 EDP44532.1 - 2.9e-32 112.4 0.7 3.6e-32 112.0 0.7 1.1 1 0 0 1 1 1 1 Ctr copper transporter family LapA_dom PF06305.11 EDP44532.1 - 0.18 11.7 0.3 0.39 10.6 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain PIG-H PF10181.9 EDP44533.1 - 2e-14 53.2 0.0 3.4e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Hydrolase_4 PF12146.8 EDP44533.1 - 0.017 14.4 0.0 0.79 8.9 0.0 2.3 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EDP44533.1 - 0.098 12.1 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family WD40 PF00400.32 EDP44534.1 - 7.4e-10 39.3 4.6 0.88 10.5 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Dsl1_C PF11989.8 EDP44535.1 - 6e-05 22.9 0.1 0.00011 21.9 0.1 1.4 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal Zw10 PF06248.13 EDP44535.1 - 0.012 14.3 0.8 0.044 12.4 0.1 2.1 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 LSM PF01423.22 EDP44536.1 - 1.4e-19 69.6 0.1 1.8e-19 69.2 0.1 1.2 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EDP44536.1 - 0.093 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain COPIIcoated_ERV PF07970.12 EDP44537.1 - 8.7e-37 127.1 0.1 9.5e-34 117.2 0.0 2.2 2 0 0 2 2 2 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EDP44537.1 - 1.2e-10 41.6 0.2 3.6e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) YbgT_YccB PF08173.11 EDP44537.1 - 0.048 13.8 0.4 0.12 12.5 0.4 1.7 1 0 0 1 1 1 0 Membrane bound YbgT-like protein DUF4110 PF13422.6 EDP44538.1 - 1.3e-10 41.2 0.0 3.5e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4110) Kelch_3 PF13415.6 EDP44538.1 - 2.6e-09 37.1 0.1 0.00078 19.7 0.0 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EDP44538.1 - 3.2e-06 27.0 9.4 0.013 15.4 0.1 4.5 3 1 1 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EDP44538.1 - 1.1e-05 25.5 0.2 0.0016 18.6 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 EDP44538.1 - 0.0012 18.7 0.0 0.29 11.2 0.2 3.4 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 EDP44538.1 - 0.0017 17.9 0.1 0.014 15.0 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EDP44538.1 - 0.0021 18.0 4.4 0.63 10.1 0.2 4.2 4 1 0 4 4 4 1 Kelch motif CDC45 PF02724.14 EDP44538.1 - 0.018 13.4 3.5 0.024 13.0 3.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2722 PF10846.8 EDP44538.1 - 0.039 12.9 1.9 0.058 12.3 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RXT2_N PF08595.11 EDP44538.1 - 0.64 10.0 6.4 5.2 7.1 6.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal RRN3 PF05327.11 EDP44538.1 - 1.6 7.2 4.7 1.9 6.9 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 EDP44538.1 - 2.8 6.1 12.4 4 5.5 12.4 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDP44538.1 - 3.2 7.0 14.8 0.38 10.0 9.6 1.8 2 0 0 2 2 2 0 NOA36 protein SpoIIE PF07228.12 EDP44539.1 - 4.7e-12 46.2 0.0 5.4e-11 42.8 0.0 2.3 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EDP44539.1 - 0.00021 21.0 0.1 0.0026 17.4 0.1 2.5 1 1 0 1 1 1 1 Protein phosphatase 2C tRNA_anti-codon PF01336.25 EDP44540.1 - 0.013 15.5 0.1 0.062 13.3 0.1 2.0 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain Ribosomal_L19 PF01245.20 EDP44540.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L19 Nup96 PF12110.8 EDP44541.1 - 8e-90 300.9 10.1 1.3e-89 300.2 10.1 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EDP44541.1 - 4.7e-50 169.6 0.0 7.3e-50 168.9 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EDP44541.1 - 5.3e-07 30.4 226.6 8.3e-06 26.6 43.7 8.0 3 1 5 8 8 8 3 Nucleoporin FG repeat region ketoacyl-synt PF00109.26 EDP44542.1 - 3.3e-62 210.4 0.0 6.8e-62 209.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain NAD_binding_4 PF07993.12 EDP44542.1 - 1.1e-46 159.2 0.1 2.9e-46 157.7 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein Acyl_transf_1 PF00698.21 EDP44542.1 - 3.1e-41 141.9 0.2 6.4e-41 140.9 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EDP44542.1 - 6.9e-36 123.8 0.4 1.3e-34 119.6 0.0 2.8 3 0 0 3 3 3 1 KR domain Ketoacyl-synt_C PF02801.22 EDP44542.1 - 4e-32 110.7 0.0 8.2e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EDP44542.1 - 5.5e-24 84.9 0.0 1e-23 84.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EDP44542.1 - 2.6e-13 50.4 0.0 6.3e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 EDP44542.1 - 2.8e-12 46.6 0.0 5.9e-11 42.3 0.0 2.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 EDP44542.1 - 4.8e-12 46.0 0.1 4.6e-11 42.8 0.0 2.8 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP44542.1 - 3.9e-07 31.2 0.0 1.6e-06 29.2 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.15 EDP44542.1 - 0.00018 20.8 0.1 0.0012 18.0 0.1 2.2 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein PP-binding PF00550.25 EDP44542.1 - 0.0003 21.1 0.5 0.0011 19.3 0.5 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 EDP44542.1 - 0.0011 18.4 0.1 0.046 13.2 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase DapB_N PF01113.20 EDP44542.1 - 0.0083 16.2 0.1 0.029 14.5 0.1 2.0 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GDP_Man_Dehyd PF16363.5 EDP44542.1 - 0.011 15.2 0.0 0.21 10.9 0.0 2.7 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase YAcAr PF10686.9 EDP44542.1 - 0.018 15.0 1.8 3 7.9 0.1 3.4 3 0 0 3 3 3 0 YspA, cpYpsA-related SLOG family ADH_N PF08240.12 EDP44542.1 - 0.018 14.9 1.1 0.064 13.1 0.1 2.4 3 0 0 3 3 3 0 Alcohol dehydrogenase GroES-like domain NmrA PF05368.13 EDP44542.1 - 0.025 14.1 0.1 0.076 12.6 0.1 1.9 1 0 0 1 1 1 0 NmrA-like family ThiF PF00899.21 EDP44542.1 - 0.1 11.9 0.0 0.28 10.5 0.0 1.7 2 0 0 2 2 1 0 ThiF family TolA_bind_tri PF16331.5 EDP44543.1 - 0.0097 16.0 0.4 0.026 14.6 0.1 1.8 2 0 0 2 2 2 1 TolA binding protein trimerisation Nramp PF01566.18 EDP44544.1 - 3.3e-87 292.8 18.3 2.7e-50 171.4 4.5 2.2 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein MRP-L47 PF06984.13 EDP44545.1 - 1.1e-18 67.1 0.3 1.8e-18 66.4 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 EDP44545.1 - 0.00031 20.7 1.1 0.0011 18.9 1.1 1.9 1 1 0 1 1 1 1 Ribosomal L29 protein DUF3703 PF12487.8 EDP44545.1 - 0.073 12.9 2.0 2.7 7.9 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3703) Elong_Iki1 PF10483.9 EDP44545.1 - 0.15 11.5 0.1 0.2 11.1 0.1 1.1 1 0 0 1 1 1 0 Elongator subunit Iki1 VPS13_mid_rpt PF16910.5 EDP44546.1 - 1.8e-88 295.9 0.4 1.8e-87 292.7 0.0 2.5 3 0 0 3 3 3 1 Repeating coiled region of VPS13 VPS13 PF16908.5 EDP44546.1 - 5.3e-77 258.8 1.6 5.5e-76 255.5 0.3 2.4 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EDP44546.1 - 2.5e-38 130.8 0.4 8.5e-38 129.0 0.4 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 EDP44547.1 - 8.8e-63 212.2 0.0 1.5e-60 204.9 0.0 3.4 5 0 0 5 5 5 2 SHR-binding domain of vacuolar-sorting associated protein 13 LBP_BPI_CETP_C PF02886.17 EDP44547.1 - 0.036 13.5 0.5 0.085 12.3 0.5 1.5 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain VPS13_C PF16909.5 EDP44548.1 - 3.7e-27 95.2 2.5 1.4e-21 77.1 0.1 2.7 2 1 1 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 EDP44548.1 - 4.4e-08 33.4 0.0 2.6e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain CBFB_NFYA PF02045.15 EDP44549.1 - 4.6e-23 81.6 11.0 2.2e-22 79.4 11.0 2.1 1 1 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B AAA_9 PF12781.7 EDP44550.1 - 1e-64 217.7 0.2 5.3e-61 205.6 0.0 2.5 2 0 0 2 2 2 2 ATP-binding dynein motor region MT PF12777.7 EDP44550.1 - 3.8e-38 131.4 1.5 6.5e-38 130.6 1.5 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 EDP44550.1 - 6.2e-22 78.2 0.0 1.5e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 EDP44550.1 - 2.5e-21 76.2 0.0 6.2e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EDP44550.1 - 9.3e-19 67.7 0.0 3.2e-18 65.9 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain TPR_MLP1_2 PF07926.12 EDP44550.1 - 0.0077 16.3 2.5 0.0077 16.3 2.5 4.4 4 1 0 4 4 4 1 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EDP44550.1 - 0.017 15.7 1.5 0.017 15.7 1.5 3.7 3 0 0 3 3 3 0 Apg6 coiled-coil region DUF948 PF06103.11 EDP44550.1 - 0.024 14.9 0.7 2.5 8.4 0.1 3.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AAA_8 PF12780.7 EDP44550.1 - 0.068 12.5 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 RACo_linker PF17650.1 EDP44550.1 - 0.37 10.7 2.7 0.38 10.6 0.2 2.3 2 0 0 2 2 2 0 RACo linker region LRR_9 PF14580.6 EDP44551.1 - 1.5e-55 187.4 0.2 2.3e-55 186.8 0.2 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EDP44551.1 - 2.4e-08 34.2 3.2 2.1e-05 24.8 1.2 3.6 1 1 4 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP44551.1 - 5.3e-08 32.5 3.3 1e-07 31.6 1.8 2.4 3 0 0 3 3 3 1 Leucine rich repeat HTH_38 PF13936.6 EDP44551.1 - 0.46 10.3 3.8 0.4 10.5 0.4 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Septin PF00735.18 EDP44552.1 - 5.9e-48 163.6 0.2 5.9e-48 163.6 0.2 1.5 2 0 0 2 2 2 1 Septin Strep_SA_rep PF06696.11 EDP44552.1 - 0.0054 16.7 0.5 0.0054 16.7 0.5 2.9 2 1 1 3 3 3 1 Streptococcal surface antigen repeat Exonuc_VII_L PF02601.15 EDP44552.1 - 1.1 8.7 11.0 1.5 8.3 11.0 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.9 EDP44552.1 - 1.7 9.0 10.7 0.64 10.3 6.8 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein AAA_6 PF12774.7 EDP44553.1 - 5.4e-110 367.4 0.0 1.8e-91 306.5 0.0 2.5 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EDP44553.1 - 3.3e-95 319.5 0.0 1.1e-94 317.8 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 EDP44553.1 - 1.3e-82 278.3 0.0 2.4e-82 277.4 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 AAA_7 PF12775.7 EDP44553.1 - 2.6e-41 141.1 0.0 1.1e-34 119.6 0.0 4.5 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_5 PF07728.14 EDP44553.1 - 2.1e-26 92.6 0.0 1.8e-10 41.0 0.0 5.5 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 EDP44553.1 - 8.9e-18 64.5 0.0 2e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_22 PF13401.6 EDP44553.1 - 2.6e-17 63.4 1.2 2.2e-06 28.0 0.0 6.2 6 0 0 6 6 4 3 AAA domain Dynein_AAA_lid PF17852.1 EDP44553.1 - 3.5e-12 46.5 0.0 1.1e-11 44.9 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EDP44553.1 - 1.1e-11 45.2 0.0 0.0037 17.7 0.0 5.2 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EDP44553.1 - 5.4e-09 36.7 0.0 0.59 10.7 0.0 5.5 5 0 0 5 5 4 2 AAA domain AAA_33 PF13671.6 EDP44553.1 - 1.5e-07 31.7 1.9 0.13 12.4 0.0 5.7 5 0 0 5 5 4 2 AAA domain AAA_16 PF13191.6 EDP44553.1 - 7.4e-06 26.5 33.3 0.03 14.7 0.0 8.6 9 3 0 9 9 6 4 AAA ATPase domain Mg_chelatase PF01078.21 EDP44553.1 - 5.9e-05 22.6 2.5 1.3 8.4 0.0 4.3 5 0 0 5 5 5 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDP44553.1 - 0.00027 21.3 9.5 0.12 12.7 0.0 5.3 5 0 0 5 5 4 1 AAA domain IstB_IS21 PF01695.17 EDP44553.1 - 0.00077 19.2 0.0 0.29 10.9 0.0 3.7 3 0 0 3 3 3 1 IstB-like ATP binding protein NACHT PF05729.12 EDP44553.1 - 0.0013 18.7 2.5 5.1 7.0 0.0 5.2 5 0 0 5 5 5 1 NACHT domain AAA_25 PF13481.6 EDP44553.1 - 0.0017 17.9 0.8 0.075 12.6 0.0 4.2 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EDP44553.1 - 0.0021 17.2 0.0 0.14 11.2 0.0 3.2 4 0 0 4 4 3 1 Type II/IV secretion system protein AAA_lid_1 PF17857.1 EDP44553.1 - 0.0031 17.7 0.0 0.0086 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_24 PF13479.6 EDP44553.1 - 0.0062 16.3 0.5 11 5.7 0.0 4.3 4 1 1 5 5 5 0 AAA domain TsaE PF02367.17 EDP44553.1 - 0.013 15.5 2.2 7.4 6.6 0.0 4.7 5 0 0 5 5 5 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 EDP44553.1 - 0.029 14.2 0.0 1.1 9.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EDP44553.1 - 0.03 14.7 0.0 60 4.1 0.0 3.5 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 EDP44553.1 - 0.059 13.1 16.0 6.7 6.4 0.0 5.9 6 0 0 6 6 5 0 AAA domain RuvB_N PF05496.12 EDP44553.1 - 0.15 11.8 0.5 6.7 6.4 0.0 3.2 4 0 0 4 4 3 0 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 EDP44553.1 - 0.16 11.2 0.0 7.8 5.6 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) PDDEXK_1 PF12705.7 EDP44553.1 - 0.17 11.7 2.1 1.5 8.7 0.3 3.2 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily HalX PF08663.10 EDP44553.1 - 2.5 8.5 5.8 6.3 7.2 1.1 4.4 2 0 0 2 2 2 0 HalX domain CCDC154 PF15450.6 EDP44553.1 - 4.8 5.6 5.8 9.5 4.6 1.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 154 Abhydrolase_6 PF12697.7 EDP44554.1 - 0.0091 16.6 1.2 0.0091 16.6 1.2 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF900 PF05990.12 EDP44554.1 - 0.034 13.7 0.0 0.13 11.7 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) BATS PF06968.13 EDP44555.1 - 4.6e-20 71.6 0.5 1.3e-19 70.1 0.1 2.0 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EDP44555.1 - 5.9e-15 56.0 0.1 1.2e-14 55.1 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily NUDIX PF00293.28 EDP44556.1 - 9.5e-15 54.8 0.1 1.6e-14 54.0 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain PTH2 PF01981.16 EDP44557.1 - 3.7e-44 149.8 0.0 5.1e-44 149.3 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 TPR_11 PF13414.6 EDP44557.1 - 0.0082 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 TPR repeat PhzC-PhzF PF02567.16 EDP44557.1 - 0.1 12.0 0.1 5.5 6.4 0.2 2.6 2 1 0 2 2 2 0 Phenazine biosynthesis-like protein ubiquitin PF00240.23 EDP44558.1 - 1e-69 230.2 5.4 3.1e-34 116.5 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EDP44558.1 - 8.3e-33 112.1 6.4 7.3e-16 57.8 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EDP44558.1 - 1.3e-12 48.0 1.4 0.00012 22.4 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EDP44558.1 - 3.6e-08 33.2 0.3 0.0096 15.8 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EDP44558.1 - 4.5e-08 33.3 0.4 0.012 16.0 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EDP44558.1 - 1.7e-07 31.3 0.4 0.031 14.4 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EDP44558.1 - 2.6e-06 27.9 0.1 0.098 13.2 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EDP44558.1 - 3.4e-05 23.8 8.3 5.6 7.1 0.2 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EDP44558.1 - 5.1e-05 23.2 0.0 0.29 10.9 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain HATPase_c PF02518.26 EDP44558.1 - 0.0003 21.3 1.7 0.57 10.7 0.2 2.1 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3861 PF12977.7 EDP44558.1 - 0.004 17.3 0.2 3.3 7.9 0.0 2.3 1 1 1 2 2 2 2 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 EDP44558.1 - 0.0064 16.3 0.4 4.2 7.3 0.0 2.4 2 0 0 2 2 2 2 ACT domain DUF2870 PF11069.8 EDP44558.1 - 0.012 15.9 0.1 11 6.5 0.0 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF2870) Big_7 PF17957.1 EDP44558.1 - 0.015 16.0 0.0 9.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig domain TmoB PF06234.12 EDP44558.1 - 0.02 14.9 0.5 9.9 6.3 0.1 2.7 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) PDGLE PF13190.6 EDP44558.1 - 0.048 13.6 0.6 12 5.8 0.1 2.7 1 1 1 2 2 2 0 PDGLE domain FlgD_ig PF13860.6 EDP44558.1 - 0.093 12.6 1.2 15 5.5 0.1 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain DUF969 PF06149.12 EDP44558.1 - 0.13 11.7 0.0 6.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF969) ProRS-C_2 PF09181.10 EDP44558.1 - 0.16 12.1 0.5 25 5.1 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 EDP44558.1 - 0.18 12.0 9.6 2.8 8.2 1.5 2.3 2 0 0 2 2 2 0 Tash protein PEST motif FERM_f0 PF16511.5 EDP44558.1 - 0.22 11.8 1.2 42 4.5 0.1 3.2 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Plexin_cytopl PF08337.12 EDP44558.1 - 0.88 8.2 5.0 8.7 4.9 0.4 2.9 2 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain ATP-synt_F PF01990.17 EDP44559.1 - 5.9e-31 106.7 0.1 6.8e-31 106.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF257 PF03192.13 EDP44559.1 - 0.025 14.4 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 Hist_deacetyl PF00850.19 EDP44560.1 - 1.1e-66 225.5 0.4 1.6e-66 224.9 0.1 1.4 2 0 0 2 2 2 1 Histone deacetylase domain GYF PF02213.16 EDP44561.1 - 1.3e-15 56.7 0.5 2.6e-15 55.8 0.5 1.5 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EDP44561.1 - 0.00026 20.7 0.2 0.00055 19.7 0.2 1.5 1 0 0 1 1 1 1 GYF domain 2 RRP7 PF12923.7 EDP44561.1 - 0.21 11.7 0.9 3 8.0 0.0 2.6 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Cupin_8 PF13621.6 EDP44562.1 - 0.054 13.2 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 Cupin-like domain 4HBT_3 PF13622.6 EDP44563.1 - 1.6e-30 107.2 0.1 2.6e-30 106.5 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EDP44563.1 - 1.3e-14 54.2 1.3 9.5e-11 41.7 0.1 3.6 3 1 1 4 4 4 2 Acyl-CoA thioesterase PEMT PF04191.13 EDP44563.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Phospholipid methyltransferase Sec1 PF00995.23 EDP44564.1 - 3.7e-117 393.0 0.0 4.2e-117 392.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DnaJ_C PF01556.18 EDP44565.1 - 8.9e-35 120.0 0.0 1.3e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain LMWPc PF01451.21 EDP44565.1 - 4e-29 101.8 0.1 7.7e-29 100.9 0.1 1.4 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DnaJ PF00226.31 EDP44565.1 - 9.6e-23 80.1 1.1 1.6e-22 79.4 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDP44565.1 - 6.6e-11 42.4 18.4 6.7e-11 42.4 16.9 1.9 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 EDP44565.1 - 2.8 7.9 16.4 0.64 10.0 2.4 3.4 1 1 4 5 5 5 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDP44565.1 - 9.2 6.3 6.1 48 4.0 6.1 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Methyltr_RsmB-F PF01189.17 EDP44566.1 - 3.6e-32 111.6 0.0 8.1e-30 104.0 0.0 2.7 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDP44566.1 - 0.00015 21.9 0.0 0.00029 21.0 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Mito_carr PF00153.27 EDP44567.1 - 2.5e-20 72.2 1.2 2.6e-07 30.5 0.0 5.1 4 1 0 4 4 4 4 Mitochondrial carrier protein Glyco_transf_4 PF13439.6 EDP44568.1 - 1.8e-15 57.4 5.1 2.4e-14 53.7 3.7 2.7 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EDP44568.1 - 3.1e-07 31.0 13.5 5e-06 27.0 9.9 2.4 2 1 0 2 2 2 2 Glycosyl transferase 4-like domain ALG11_N PF15924.5 EDP44568.1 - 0.00062 19.9 0.2 0.0077 16.3 0.2 2.6 1 1 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EDP44568.1 - 0.019 14.5 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 EDP44568.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like Cep57_MT_bd PF06657.13 EDP44569.1 - 7e-09 36.0 2.1 7e-09 36.0 2.1 4.0 3 1 0 3 3 3 1 Centrosome microtubule-binding domain of Cep57 SesA PF17107.5 EDP44569.1 - 0.0066 16.6 1.4 0.12 12.6 0.2 3.2 3 1 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NPV_P10 PF05531.12 EDP44569.1 - 0.021 15.3 0.3 0.06 13.8 0.3 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MIP-T3_C PF17749.1 EDP44569.1 - 0.1 12.6 5.4 2.9 7.9 5.2 2.7 2 1 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region V-SNARE PF05008.15 EDP44569.1 - 0.15 12.4 3.1 1.3 9.5 2.3 2.8 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Cep3 PF16846.5 EDP44569.1 - 0.23 9.9 0.3 0.42 9.0 0.3 1.3 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B Syntaxin PF00804.25 EDP44569.1 - 1.3 8.7 11.5 0.16 11.7 5.5 2.4 3 0 0 3 3 3 0 Syntaxin DUF1664 PF07889.12 EDP44569.1 - 2.4 8.2 5.8 1.2 9.2 1.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CLZ PF16526.5 EDP44569.1 - 3.7 8.0 9.6 10 6.5 2.6 3.5 2 1 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ABC_tran_CTD PF16326.5 EDP44569.1 - 4.8 7.5 10.0 0.87 9.9 1.6 3.3 4 0 0 4 4 4 0 ABC transporter C-terminal domain SUI1 PF01253.22 EDP44570.1 - 1.8e-29 102.1 0.9 1.6e-28 99.1 0.2 2.0 1 1 1 2 2 2 2 Translation initiation factor SUI1 Fcf1 PF04900.12 EDP44571.1 - 1.6e-36 124.7 1.7 1.6e-36 124.7 1.7 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EDP44571.1 - 5.1e-13 49.3 0.0 2.2e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 PIN like domain UreD PF01774.17 EDP44572.1 - 8.6e-63 212.1 0.0 1.1e-62 211.8 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein Pkinase PF00069.25 EDP44573.1 - 7.9e-64 215.6 0.0 7.2e-63 212.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44573.1 - 6.6e-26 91.1 0.0 9e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44573.1 - 4.5e-05 22.9 0.0 9.1e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP44573.1 - 0.0011 19.0 0.3 0.008 16.1 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP44573.1 - 0.0034 16.8 0.0 0.0052 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EDP44573.1 - 0.018 14.7 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 EDP44573.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Arf PF00025.21 EDP44574.1 - 2.4e-65 219.3 0.0 2.9e-65 219.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EDP44574.1 - 7e-10 38.6 0.0 2.3e-06 27.0 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EDP44574.1 - 9.3e-09 35.0 0.0 1.4e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EDP44574.1 - 2.6e-07 30.9 0.0 7.3e-07 29.4 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EDP44574.1 - 6.9e-07 29.4 0.0 1.3e-06 28.5 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EDP44574.1 - 3e-06 26.9 0.0 4.3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EDP44574.1 - 4.1e-05 23.1 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EDP44574.1 - 0.064 13.0 0.0 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_L26 PF16906.5 EDP44575.1 - 1.7e-15 57.2 0.2 1.8e-15 57.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal WD40 PF00400.32 EDP44576.1 - 1.4e-45 152.3 25.3 1.6e-06 28.7 0.0 8.8 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 EDP44576.1 - 1.9e-09 37.3 0.2 4.4e-09 36.1 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EDP44576.1 - 7.7e-08 32.0 0.8 1.9e-07 30.8 0.8 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EDP44576.1 - 1.9e-07 30.1 13.2 0.32 9.6 0.0 6.4 3 2 3 7 7 7 5 Nucleoporin Nup120/160 F-box_4 PF15966.5 EDP44576.1 - 0.0012 18.7 0.0 0.003 17.4 0.0 1.7 1 0 0 1 1 1 1 F-box PALB2_WD40 PF16756.5 EDP44576.1 - 0.95 8.3 8.0 22 3.9 0.1 5.0 4 2 1 6 6 6 0 Partner and localizer of BRCA2 WD40 domain p450 PF00067.22 EDP44577.1 - 3.6e-53 181.0 0.0 6.1e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Mon2_C PF16206.5 EDP44578.1 - 7.7e-06 24.4 0.0 9.2e-06 24.1 0.0 1.1 1 0 0 1 1 1 1 C-terminal region of Mon2 protein DCB PF16213.5 EDP44579.1 - 6.4e-39 133.4 3.0 1.6e-38 132.1 3.0 1.8 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EDP44579.1 - 7.1e-30 104.0 1.1 7.1e-30 104.0 1.1 3.4 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EDP44579.1 - 0.00023 21.0 0.0 0.0018 18.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) DUF1664 PF07889.12 EDP44580.1 - 0.0073 16.3 11.4 0.45 10.6 1.7 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) CALCOCO1 PF07888.11 EDP44580.1 - 0.031 13.2 23.9 0.064 12.1 23.9 1.4 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like RPW8 PF05659.11 EDP44580.1 - 0.035 13.8 1.1 0.12 12.1 0.1 2.2 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ERM PF00769.19 EDP44580.1 - 0.063 13.1 23.8 0.11 12.3 23.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family MAD PF05557.13 EDP44580.1 - 0.21 9.9 20.8 0.29 9.4 20.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein ADIP PF11559.8 EDP44580.1 - 0.21 11.7 30.0 0.97 9.5 3.9 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.9 EDP44580.1 - 0.22 10.0 17.7 0.5 8.9 2.5 2.2 1 1 1 2 2 2 0 Macoilin family CP12 PF02672.15 EDP44580.1 - 0.35 11.7 10.3 1.2 10.0 1.2 3.1 2 1 1 3 3 3 0 CP12 domain Rnk_N PF14760.6 EDP44580.1 - 0.45 11.0 3.2 0.38 11.3 0.5 2.4 2 0 0 2 2 2 0 Rnk N-terminus DUF3450 PF11932.8 EDP44580.1 - 0.46 9.8 23.1 1 8.6 6.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 EDP44580.1 - 0.55 10.7 27.8 0.28 11.7 5.5 3.0 1 1 2 3 3 3 0 Apg6 coiled-coil region Filament PF00038.21 EDP44580.1 - 0.57 9.7 25.9 3.3 7.2 10.4 2.4 1 1 1 2 2 2 0 Intermediate filament protein HAP1_N PF04849.13 EDP44580.1 - 0.62 9.2 26.8 0.58 9.3 8.4 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region YabA PF06156.13 EDP44580.1 - 0.64 10.7 15.3 2.6 8.7 4.9 3.4 2 1 2 4 4 3 0 Initiation control protein YabA LMBR1 PF04791.16 EDP44580.1 - 0.82 8.5 6.3 1.3 7.8 6.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein THOC7 PF05615.13 EDP44580.1 - 1.3 9.3 22.0 11 6.3 6.6 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 Fib_alpha PF08702.10 EDP44580.1 - 1.6 8.9 14.3 0.049 13.8 2.7 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EDP44580.1 - 2.2 8.7 23.3 3.7 8.0 6.7 2.3 1 1 1 2 2 2 0 Fez1 BRE1 PF08647.11 EDP44580.1 - 3.2 7.9 15.9 1.1 9.4 3.5 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase TMF_TATA_bd PF12325.8 EDP44580.1 - 5.7 7.2 22.1 2.1 8.6 3.6 2.7 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 EDP44580.1 - 6 5.6 19.3 25 3.6 19.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) NPV_P10 PF05531.12 EDP44580.1 - 7.1 7.2 13.1 7.3 7.1 0.1 4.5 1 1 4 5 5 5 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 EDP44580.1 - 7.3 7.0 12.5 10 6.5 1.5 3.3 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2353 PF09789.9 EDP44580.1 - 8.6 5.6 21.4 5 6.4 3.5 2.6 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) P5CR_dimer PF14748.6 EDP44581.1 - 1.8e-36 124.5 5.0 1.8e-36 124.5 5.0 2.4 3 0 0 3 3 3 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EDP44581.1 - 1.9e-11 44.4 0.4 1.5e-09 38.3 0.4 2.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 EDP44581.1 - 0.022 13.8 0.2 0.05 12.6 0.1 1.5 2 0 0 2 2 2 0 Prephenate dehydrogenase DUF4889 PF16230.5 EDP44581.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) AAA PF00004.29 EDP44582.1 - 2.8e-45 154.0 0.1 1.5e-44 151.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDP44582.1 - 6.8e-10 38.8 0.2 4e-09 36.3 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EDP44582.1 - 1.4e-08 34.8 0.1 5.7e-08 32.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP44582.1 - 9.8e-08 32.6 0.2 2.4e-05 24.8 0.0 2.7 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EDP44582.1 - 1.5e-07 31.7 0.0 3.1e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 EDP44582.1 - 5.8e-07 29.2 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain DUF815 PF05673.13 EDP44582.1 - 4.3e-06 26.1 0.3 1.7e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EDP44582.1 - 0.00014 22.2 2.1 0.0097 16.2 0.1 3.1 3 1 1 4 4 2 1 AAA domain RuvB_N PF05496.12 EDP44582.1 - 0.00018 21.3 0.0 0.00049 19.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EDP44582.1 - 0.00019 21.2 0.0 0.00056 19.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EDP44582.1 - 0.00089 19.2 0.1 0.0052 16.7 0.0 2.4 3 0 0 3 3 3 1 NTPase AAA_28 PF13521.6 EDP44582.1 - 0.00092 19.5 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP44582.1 - 0.0012 19.4 0.0 0.0055 17.2 0.0 2.1 3 0 0 3 3 1 1 AAA domain TsaE PF02367.17 EDP44582.1 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EDP44582.1 - 0.002 18.1 0.0 0.0055 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EDP44582.1 - 0.0022 18.4 0.0 0.0045 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 EDP44582.1 - 0.0033 17.0 0.1 0.02 14.4 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EDP44582.1 - 0.0049 17.0 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EDP44582.1 - 0.0051 16.3 0.1 0.56 9.6 0.0 2.8 3 0 0 3 3 3 1 Bacterial TniB protein Prot_ATP_OB_N PF17758.1 EDP44582.1 - 0.0057 16.3 0.2 0.073 12.7 0.0 2.6 3 0 0 3 3 3 1 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 EDP44582.1 - 0.0057 16.4 0.2 0.029 14.1 0.0 2.3 3 0 0 3 3 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDP44582.1 - 0.0062 15.9 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDP44582.1 - 0.0062 16.5 0.1 0.07 13.0 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_3 PF07726.11 EDP44582.1 - 0.0079 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EDP44582.1 - 0.012 14.8 0.1 0.037 13.2 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_24 PF13479.6 EDP44582.1 - 0.019 14.7 0.1 0.04 13.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDP44582.1 - 0.029 14.3 0.1 0.23 11.4 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea SWIRM-assoc_1 PF16495.5 EDP44582.1 - 0.035 14.1 1.0 0.073 13.0 1.0 1.5 1 0 0 1 1 1 0 SWIRM-associated region 1 AAA_23 PF13476.6 EDP44582.1 - 0.039 14.5 0.2 1 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EDP44582.1 - 0.05 13.4 0.0 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EDP44582.1 - 0.059 13.2 0.1 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 EDP44582.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EDP44582.1 - 0.089 12.4 1.2 0.19 11.3 0.4 2.0 2 1 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 EDP44582.1 - 0.096 12.4 0.3 1.6 8.4 0.0 2.7 2 2 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.6 EDP44582.1 - 0.097 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EDP44582.1 - 0.13 12.6 0.1 0.39 11.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain QH-AmDH_gamma PF08992.11 EDP44583.1 - 0.094 12.7 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, gamma subunit SET PF00856.28 EDP44584.1 - 3.4e-09 37.3 0.0 3.4e-09 37.3 0.0 2.4 2 1 0 2 2 2 1 SET domain Paramyxo_ncap PF00973.19 EDP44584.1 - 2.7 6.8 4.0 4.5 6.1 4.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Phosphoesterase PF04185.14 EDP44585.1 - 1.1e-75 255.1 3.8 1.5e-75 254.7 3.8 1.1 1 0 0 1 1 1 1 Phosphoesterase family SH2_2 PF14633.6 EDP44586.1 - 1.8e-76 256.4 0.0 1.8e-76 256.4 0.0 1.6 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 EDP44586.1 - 2.3e-23 82.6 0.0 6e-23 81.3 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 EDP44586.1 - 1.3e-19 70.5 0.0 2.8e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EDP44586.1 - 1.8e-17 63.8 0.0 4.6e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 EDP44586.1 - 5.3e-13 49.4 25.0 5.3e-13 49.4 25.0 4.5 3 1 2 5 5 5 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 EDP44586.1 - 0.00037 21.3 0.0 0.0015 19.3 0.0 2.3 1 0 0 1 1 1 1 HHH domain SH2 PF00017.24 EDP44586.1 - 0.00073 19.6 0.0 0.0017 18.4 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Tex_N PF09371.10 EDP44586.1 - 0.0079 15.9 0.0 0.022 14.4 0.0 1.7 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 EDP44586.1 - 0.012 16.0 0.0 0.028 14.9 0.0 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain S1 PF00575.23 EDP44586.1 - 0.019 15.3 0.1 0.078 13.3 0.1 2.0 2 0 0 2 2 2 0 S1 RNA binding domain SOG2 PF10428.9 EDP44587.1 - 1.4e-47 163.1 22.6 6.6e-40 137.8 0.3 3.0 2 1 1 3 3 3 2 RAM signalling pathway protein Dynamin_N PF00350.23 EDP44587.1 - 0.14 12.2 0.0 0.37 10.8 0.0 1.7 2 0 0 2 2 2 0 Dynamin family RRM_1 PF00076.22 EDP44588.1 - 1.2e-09 37.8 0.1 4.6e-06 26.4 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.8 EDP44588.1 - 0.0026 18.0 0.1 0.0065 16.7 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EDP44588.1 - 0.031 14.7 0.2 0.068 13.7 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP44588.1 - 0.071 14.0 0.2 0.22 12.4 0.2 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDP44588.1 - 0.093 12.5 0.4 0.19 11.5 0.4 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type Glyco_hydro_63 PF03200.16 EDP44589.1 - 8.9e-156 519.5 0.0 1.2e-154 515.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EDP44589.1 - 1.1e-46 159.7 0.2 3.5e-46 158.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EDP44589.1 - 2.1e-06 26.9 0.2 8.3e-06 24.9 0.2 1.8 1 1 0 1 1 1 1 Trehalase Strep_SA_rep PF06696.11 EDP44589.1 - 0.059 13.4 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Streptococcal surface antigen repeat ABC_tran_CTD PF16326.5 EDP44589.1 - 0.18 12.1 0.0 0.44 10.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain SMI1_KNR4 PF09346.10 EDP44590.1 - 9.8e-21 74.5 0.0 1.8e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Phosducin PF02114.16 EDP44592.1 - 0.00023 20.2 0.0 0.00024 20.2 0.0 1.1 1 0 0 1 1 1 1 Phosducin GST_N_2 PF13409.6 EDP44593.1 - 1.4e-07 31.7 0.0 4.7e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EDP44593.1 - 6.8e-07 29.6 0.0 1.4e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EDP44593.1 - 1.2e-05 25.3 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EDP44593.1 - 0.00012 22.4 0.0 0.00027 21.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EDP44593.1 - 0.018 15.2 0.0 0.044 14.0 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP44593.1 - 0.032 14.5 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.26 EDP44596.1 - 1.4e-10 41.0 15.9 3.3e-05 24.1 4.3 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP44596.1 - 3.8e-07 30.4 14.0 0.00054 20.6 3.5 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP44596.1 - 1.8e-06 28.1 16.8 0.00037 20.8 1.8 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDP44596.1 - 0.00073 19.7 2.0 0.00073 19.7 2.0 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EDP44596.1 - 0.0093 16.3 1.3 0.033 14.6 1.3 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EDP44596.1 - 0.012 15.6 2.2 0.012 15.6 2.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EDP44596.1 - 0.046 13.5 1.5 0.046 13.5 1.5 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 EDP44596.1 - 0.057 13.4 0.9 0.057 13.4 0.9 2.2 2 0 0 2 2 2 0 BED zinc finger Zn_ribbon_SprT PF17283.2 EDP44596.1 - 1.1 9.3 10.0 2.5 8.1 1.8 2.7 1 1 1 2 2 2 0 SprT-like zinc ribbon domain NAD_kinase PF01513.21 EDP44597.1 - 1.9e-70 237.4 0.0 3.6e-70 236.5 0.0 1.4 1 0 0 1 1 1 1 ATP-NAD kinase PsbM PF05151.12 EDP44598.1 - 3.4 7.6 9.2 13 5.7 5.3 2.6 2 0 0 2 2 2 0 Photosystem II reaction centre M protein (PsbM) zf-RING_2 PF13639.6 EDP44599.1 - 8.2e-12 45.3 7.6 1.4e-11 44.6 7.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDP44599.1 - 7.2e-11 42.2 6.6 1.7e-10 41.0 6.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDP44599.1 - 2.7e-07 30.5 3.9 5.3e-07 29.6 3.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDP44599.1 - 6.1e-07 29.2 4.7 1e-06 28.5 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDP44599.1 - 2.5e-06 27.2 8.4 5.5e-06 26.1 8.4 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDP44599.1 - 3.5e-06 26.6 1.5 7.4e-06 25.6 1.5 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EDP44599.1 - 3.3e-05 23.8 5.0 5.5e-05 23.0 5.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDP44599.1 - 0.00034 20.4 8.3 0.0028 17.5 8.3 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDP44599.1 - 0.0011 19.0 6.3 0.004 17.2 6.3 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EDP44599.1 - 0.0011 18.7 4.0 0.0028 17.5 4.0 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EDP44599.1 - 0.0086 16.2 0.9 0.021 15.0 0.9 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EDP44599.1 - 0.018 14.7 6.4 0.034 13.8 6.4 1.5 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EDP44599.1 - 0.098 12.9 4.3 0.24 11.6 4.3 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EDP44599.1 - 0.16 11.8 5.6 0.96 9.3 6.0 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EDP44599.1 - 0.8 9.9 4.7 1.9 8.7 4.7 1.6 1 1 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 EDP44599.1 - 0.89 9.9 5.0 1.8 8.9 5.0 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_9 PF13901.6 EDP44599.1 - 1.9 8.4 6.1 0.9 9.5 3.7 1.6 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Ribosomal_L6 PF00347.23 EDP44600.1 - 6e-17 62.1 0.0 1.2e-09 38.6 0.0 3.4 3 2 0 3 3 3 2 Ribosomal protein L6 Ribosomal_L34e PF01199.18 EDP44601.1 - 9.9e-40 134.8 6.3 1.1e-39 134.6 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e Cytochrome_C7 PF14522.6 EDP44601.1 - 0.0035 17.3 0.2 0.0045 17.0 0.2 1.2 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c FhuF_C PF11575.8 EDP44601.1 - 0.086 12.8 4.3 3.2 7.8 0.2 2.6 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain Fungal_trans PF04082.18 EDP44602.1 - 5e-12 45.4 1.9 1.1e-11 44.3 0.3 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EDP44602.1 - 4e-07 30.0 8.5 8.9e-07 28.9 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_2 PF02230.16 EDP44603.1 - 6.5e-43 147.1 0.0 7.2e-43 146.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EDP44603.1 - 0.00019 22.1 0.6 0.00023 21.8 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EDP44603.1 - 0.0017 18.2 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDP44603.1 - 0.0033 16.7 1.6 0.35 10.1 0.5 2.6 2 1 1 3 3 3 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EDP44603.1 - 0.012 15.3 0.0 0.024 14.3 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Esterase_phd PF10503.9 EDP44603.1 - 0.041 13.4 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Myosin_head PF00063.21 EDP44604.1 - 8.1e-210 698.5 0.0 1.2e-209 698.0 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EDP44604.1 - 2.7e-46 157.6 0.0 4.4e-46 156.9 0.0 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 EDP44604.1 - 1.5e-12 47.2 1.2 4.1e-12 45.8 0.4 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EDP44604.1 - 1.7e-12 46.7 0.2 5e-12 45.2 0.2 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EDP44604.1 - 7.2e-06 25.6 0.1 2.3e-05 24.0 0.0 2.0 2 0 0 2 2 1 1 Variant SH3 domain SH3_3 PF08239.11 EDP44604.1 - 0.0021 18.3 0.8 0.0049 17.1 0.8 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Hpr_kinase_C PF07475.12 EDP44604.1 - 0.0032 17.0 0.2 1.4 8.4 0.1 2.3 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 EDP44604.1 - 0.037 14.3 0.1 0.16 12.3 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP44604.1 - 0.047 14.1 0.0 0.21 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain GCFC PF07842.12 EDP44604.1 - 0.11 12.1 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein NACHT PF05729.12 EDP44604.1 - 0.11 12.4 0.1 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EDP44604.1 - 0.13 12.0 0.3 0.41 10.3 0.1 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP44604.1 - 0.19 12.3 0.1 0.56 10.7 0.1 1.7 1 0 0 1 1 1 0 ABC transporter DHHC PF01529.20 EDP44605.1 - 3.9e-33 114.4 18.0 3.9e-33 114.4 18.0 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pex19 PF04614.12 EDP44606.1 - 3.8e-61 207.0 11.5 3.8e-61 207.0 11.5 1.5 2 0 0 2 2 2 1 Pex19 protein family Bromo_TP PF07524.13 EDP44606.1 - 0.085 12.9 0.0 0.35 10.9 0.0 2.0 2 0 0 2 2 2 0 Bromodomain associated DUF515 PF04415.12 EDP44606.1 - 5.5 5.3 7.0 9 4.6 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Rubis-subs-bind PF09273.11 EDP44607.1 - 0.0044 17.7 0.1 0.012 16.3 0.1 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Lyase_1 PF00206.20 EDP44607.1 - 0.019 14.4 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Lyase TRAM_LAG1_CLN8 PF03798.16 EDP44608.1 - 1.6e-27 96.6 12.6 1.7e-27 96.4 12.6 1.0 1 0 0 1 1 1 1 TLC domain HMGL-like PF00682.19 EDP44609.1 - 5.4e-74 249.1 0.0 7.5e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 HMGL-like Transketolase_N PF00456.21 EDP44610.1 - 8.1e-147 488.5 0.0 1.2e-146 488.0 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EDP44610.1 - 7e-44 149.6 0.0 1.3e-43 148.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EDP44610.1 - 1.1e-11 44.6 0.0 3.3e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EDP44610.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Haem_oxygenas_2 PF14518.6 EDP44610.1 - 0.11 12.3 0.1 0.26 11.1 0.0 1.6 2 0 0 2 2 2 0 Iron-containing redox enzyme NDUFA12 PF05071.16 EDP44611.1 - 1.3e-07 32.4 0.6 2.2e-07 31.6 0.6 1.4 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 GYF PF02213.16 EDP44612.1 - 0.00096 18.8 0.9 0.003 17.2 0.9 1.9 1 0 0 1 1 1 1 GYF domain DUF1018 PF06252.12 EDP44612.1 - 0.045 14.7 2.6 0.85 10.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) Clp1 PF06807.14 EDP44613.1 - 6.5e-31 107.2 0.0 1.2e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 EDP44613.1 - 9.8e-22 77.7 0.0 4.9e-17 62.3 0.0 2.9 2 1 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EDP44613.1 - 4.3e-17 62.1 0.0 6.7e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 EDP44613.1 - 0.016 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EDP44613.1 - 0.025 14.8 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EDP44613.1 - 0.026 14.6 0.0 0.42 10.7 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EDP44613.1 - 0.047 14.2 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Pro_CA PF00484.19 EDP44613.1 - 0.091 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Carbonic anhydrase Metallophos PF00149.28 EDP44614.1 - 3.9e-39 135.3 0.0 5.2e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EDP44614.1 - 3.2e-21 75.5 0.3 7.3e-21 74.4 0.2 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain TPR_2 PF07719.17 EDP44615.1 - 4.5e-11 42.0 11.6 0.0025 17.8 1.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EDP44615.1 - 2.5e-10 40.7 5.6 0.01 16.4 0.5 4.6 4 1 1 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44615.1 - 3.5e-10 39.8 8.4 0.16 12.9 0.0 5.0 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDP44615.1 - 4e-07 30.3 5.8 0.52 11.1 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44615.1 - 1e-06 28.3 9.7 0.043 13.7 0.7 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44615.1 - 4.8e-06 26.4 12.4 0.15 12.3 0.4 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP44615.1 - 5.9e-06 26.8 6.4 0.042 14.5 0.1 3.4 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44615.1 - 1.1e-05 25.7 7.6 2.7 8.4 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44615.1 - 6.7e-05 23.0 6.6 0.047 14.1 0.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP44615.1 - 0.00019 21.6 4.3 0.074 13.3 1.2 3.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EDP44615.1 - 0.00095 19.3 1.5 0.004 17.3 0.1 2.7 2 2 2 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 EDP44615.1 - 0.0021 17.0 1.3 0.012 14.5 0.1 1.9 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 EDP44615.1 - 0.0024 18.2 0.0 0.16 12.3 0.1 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF3808 PF10300.9 EDP44615.1 - 0.0053 15.6 1.3 0.022 13.5 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3808) TPR_15 PF13429.6 EDP44615.1 - 0.028 13.6 0.6 0.051 12.8 0.6 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EDP44615.1 - 0.034 14.2 9.1 0.45 10.7 0.3 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.10 EDP44615.1 - 0.073 12.1 0.1 0.099 11.6 0.1 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.20 EDP44615.1 - 0.092 13.0 0.1 3.9 7.9 0.1 2.6 2 0 0 2 2 2 0 PPR repeat TPR_4 PF07721.14 EDP44615.1 - 0.4 11.4 3.9 1.2e+02 3.8 1.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat GIY-YIG PF01541.24 EDP44616.1 - 2.4e-11 43.7 0.0 1.1e-10 41.7 0.0 2.1 2 0 0 2 2 2 1 GIY-YIG catalytic domain OrfB_Zn_ribbon PF07282.11 EDP44616.1 - 0.1 12.6 2.4 0.2 11.6 0.1 2.5 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-HC5HC2H PF13771.6 EDP44616.1 - 0.18 12.1 4.1 0.37 11.1 4.1 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 EDP44616.1 - 1 9.8 10.5 2.6 8.5 10.5 1.7 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.29 EDP44616.1 - 2 8.4 7.0 4 7.4 7.0 1.6 1 0 0 1 1 1 0 PHD-finger Arm PF00514.23 EDP44617.1 - 0.00043 20.2 1.4 0.0018 18.3 0.1 2.9 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Gasdermin_C PF17708.1 EDP44617.1 - 1 9.5 4.2 6.7 6.8 0.9 2.4 2 0 0 2 2 2 0 Gasdermin PUB domain HEAT_EZ PF13513.6 EDP44617.1 - 2.4 8.8 11.5 0.85 10.2 0.5 4.9 5 0 0 5 5 5 0 HEAT-like repeat HEAT PF02985.22 EDP44617.1 - 3.4 8.2 6.5 1.3 9.4 0.1 3.9 3 1 1 4 4 4 0 HEAT repeat Pkinase PF00069.25 EDP44618.1 - 1.1e-35 123.3 0.0 1.5e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44618.1 - 2.5e-27 95.8 0.0 3.3e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EDP44618.1 - 0.004 16.5 0.1 0.0076 15.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDP44618.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EDP44618.1 - 0.043 12.6 1.2 0.069 11.9 0.0 1.9 3 0 0 3 3 3 0 Fungal protein kinase Mem_trans PF03547.18 EDP44620.1 - 2.9e-28 98.4 5.6 2.7e-27 95.2 5.6 2.1 1 1 0 1 1 1 1 Membrane transport protein Ubiquitin_4 PF18036.1 EDP44620.1 - 3 8.0 4.3 0.64 10.1 0.3 1.8 2 0 0 2 2 2 0 Ubiquitin-like domain DUF726 PF05277.12 EDP44621.1 - 2e-101 339.4 0.0 2.8e-101 338.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_1 PF00561.20 EDP44621.1 - 0.0041 16.8 0.2 0.11 12.2 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Glyco_hydro_18 PF00704.28 EDP44622.1 - 6.4e-89 298.8 0.4 7.3e-89 298.6 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 WD40 PF00400.32 EDP44623.1 - 1.9e-22 79.1 12.3 1.8e-05 25.4 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44623.1 - 0.0003 21.0 0.1 13 6.2 0.0 4.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP44623.1 - 0.00071 18.6 1.0 1.5 7.7 0.2 4.0 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SHQ1 PF04925.15 EDP44624.1 - 7.9e-28 97.2 0.7 2.1e-27 95.8 0.7 1.5 1 1 0 1 1 1 1 SHQ1 protein Ribosomal_S15 PF00312.22 EDP44625.1 - 2.3e-23 82.2 2.0 2.4e-23 82.2 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S15 EXS PF03124.14 EDP44626.1 - 4e-88 295.9 28.2 5.1e-88 295.6 28.2 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EDP44626.1 - 8.4e-38 131.3 0.6 8.4e-38 131.3 0.6 1.5 2 0 0 2 2 2 1 SPX domain SCIMP PF15050.6 EDP44626.1 - 0.08 13.4 0.1 0.16 12.4 0.1 1.4 1 0 0 1 1 1 0 SCIMP protein Exo84_C PF16528.5 EDP44627.1 - 3.3e-48 164.2 0.0 7e-48 163.2 0.0 1.5 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EDP44627.1 - 2.4e-14 53.1 1.4 5.3e-14 52.1 1.4 1.6 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 EDP44627.1 - 2.1e-06 27.9 0.6 5.1e-06 26.6 0.6 1.6 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Dopey_N PF04118.14 EDP44628.1 - 3.9e-102 341.5 0.1 3.9e-102 341.5 0.1 2.3 3 0 0 3 3 3 1 Dopey, N-terminal Urb2 PF10441.9 EDP44628.1 - 0.29 11.0 4.3 0.85 9.5 0.3 3.6 2 0 0 2 2 2 0 Urb2/Npa2 family Oxysterol_BP PF01237.18 EDP44629.1 - 3e-114 381.7 0.0 1e-113 380.0 0.0 1.7 1 1 0 1 1 1 1 Oxysterol-binding protein Nop14 PF04147.12 EDP44629.1 - 1.6 6.8 4.2 0.19 9.9 0.1 1.4 2 0 0 2 2 2 0 Nop14-like family PH_8 PF15409.6 EDP44630.1 - 3.2e-16 59.4 0.1 5.7e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EDP44630.1 - 5.9e-05 23.5 0.1 0.0001 22.7 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EDP44630.1 - 0.0051 17.2 0.3 0.013 15.9 0.1 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain RabGAP-TBC PF00566.18 EDP44631.1 - 1.5e-20 73.8 0.4 1.5e-20 73.8 0.4 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 EDP44631.1 - 0.0033 17.6 4.1 0.0033 17.6 4.1 2.5 2 1 1 3 3 3 1 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 EDP44633.1 - 3.3e-07 30.3 14.8 6e-07 29.5 14.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EDP44633.1 - 0.0015 18.6 11.2 0.0015 18.6 11.2 1.8 1 1 1 2 2 2 1 Basic region leucine zipper ATG16 PF08614.11 EDP44633.1 - 0.0029 17.8 5.1 0.0052 17.0 5.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 EDP44633.1 - 0.017 15.7 7.0 0.027 15.0 7.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region IGFBP PF00219.18 EDP44633.1 - 0.11 13.2 2.3 0.22 12.2 0.4 2.5 2 0 0 2 2 2 0 Insulin-like growth factor binding protein Cortex-I_coil PF09304.10 EDP44633.1 - 0.16 12.2 8.6 0.3 11.3 8.6 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil DUF601 PF04642.12 EDP44633.1 - 0.23 10.9 7.9 0.43 10.0 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DUF724 PF05266.14 EDP44633.1 - 1.2 8.9 7.1 2.4 7.9 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4189 PF13827.6 EDP44633.1 - 2.3 8.8 10.5 6 7.5 2.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4189) Ribosomal_S8e PF01201.22 EDP44634.1 - 1.1e-54 184.3 0.2 1.3e-54 184.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SurE PF01975.17 EDP44635.1 - 1.5e-09 37.9 0.0 1.5e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 Survival protein SurE HofP PF10748.9 EDP44635.1 - 0.12 11.9 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 DNA utilization proteins HofP WD40 PF00400.32 EDP44636.1 - 5.5e-29 99.8 25.5 0.00057 20.6 0.0 9.5 9 1 0 9 9 9 7 WD domain, G-beta repeat Utp12 PF04003.12 EDP44636.1 - 5.1e-20 71.8 1.1 9.8e-20 70.9 1.1 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDP44636.1 - 4.6e-13 49.3 0.1 0.0084 16.4 0.0 5.6 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP44636.1 - 4.2e-06 25.9 0.0 0.17 10.8 0.0 3.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EDP44636.1 - 0.001 17.8 0.3 0.0032 16.2 0.1 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 EDP44636.1 - 0.015 14.7 0.0 0.55 9.5 0.0 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal PQQ_3 PF13570.6 EDP44636.1 - 0.38 11.3 3.9 35 5.1 0.1 4.5 5 0 0 5 5 5 0 PQQ-like domain Oxysterol_BP PF01237.18 EDP44638.1 - 8.2e-55 186.1 0.3 2.6e-52 177.9 0.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein PI3_PI4_kinase PF00454.27 EDP44639.1 - 6.1e-52 176.9 0.0 1.4e-51 175.7 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EDP44639.1 - 5.9e-23 81.6 0.0 1.1e-22 80.8 0.0 1.4 1 0 0 1 1 1 1 FAT domain UME PF08064.13 EDP44639.1 - 4e-19 68.4 0.0 2.7e-18 65.8 0.0 2.6 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.20 EDP44639.1 - 4e-08 32.9 0.1 1.2e-07 31.4 0.1 1.9 1 0 0 1 1 1 1 FATC domain DUF3385 PF11865.8 EDP44639.1 - 0.061 13.2 3.2 11 5.9 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) TPR_11 PF13414.6 EDP44639.1 - 0.11 12.2 0.9 0.24 11.1 0.1 2.0 2 0 0 2 2 2 0 TPR repeat TPR_17 PF13431.6 EDP44639.1 - 0.16 12.4 0.0 1.1 9.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EDP44639.1 - 2.1 9.4 14.5 7.7 7.6 0.1 6.9 6 1 1 7 7 7 0 Tetratricopeptide repeat Porphobil_deam PF01379.20 EDP44640.1 - 6.2e-67 225.1 0.0 1e-66 224.4 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EDP44640.1 - 1.2e-15 57.6 0.2 5.1e-13 49.2 0.2 2.5 1 1 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain WD40 PF00400.32 EDP44641.1 - 9e-05 23.2 0.1 5.6 8.0 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44641.1 - 0.0001 22.6 0.0 1 9.7 0.0 4.4 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EDP44641.1 - 0.012 15.5 0.0 0.039 13.9 0.0 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat Peptidase_M23 PF01551.22 EDP44642.1 - 0.0056 16.9 0.0 0.0084 16.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M23 CBF PF03914.17 EDP44643.1 - 4.5e-27 95.1 2.1 7.8e-26 91.1 0.3 2.7 3 0 0 3 3 3 2 CBF/Mak21 family MTS PF05175.14 EDP44644.1 - 0.0013 18.3 0.1 2.1 7.9 0.1 3.0 2 1 0 2 2 2 2 Methyltransferase small domain TFIID_20kDa PF03847.13 EDP44645.1 - 5.4e-33 113.3 0.6 9.6e-33 112.5 0.6 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 EDP44645.1 - 0.0012 19.1 0.0 0.0032 17.7 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP44645.1 - 0.0026 18.1 0.0 0.0026 18.1 0.0 3.4 3 1 0 3 3 3 1 Core histone H2A/H2B/H3/H4 DUF2828 PF11443.8 EDP44645.1 - 0.079 11.0 18.6 0.14 10.2 18.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SpoIIP PF07454.11 EDP44645.1 - 1.7 8.1 24.1 4.8 6.5 24.1 1.9 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SID-1_RNA_chan PF13965.6 EDP44645.1 - 8.3 4.7 8.5 12 4.1 8.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CoaE PF01121.20 EDP44646.1 - 2.8e-38 131.4 0.0 3.3e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EDP44646.1 - 0.0079 16.4 0.0 0.012 15.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP44646.1 - 0.024 15.2 0.0 0.026 15.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDP44646.1 - 0.031 14.5 0.0 0.043 14.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 EDP44647.1 - 4.3e-07 30.5 4.7 0.068 14.1 0.1 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat Pyr_redox_2 PF07992.14 EDP44648.1 - 1.2e-63 215.1 1.5 2.2e-63 214.2 1.5 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EDP44648.1 - 1.1e-28 99.7 0.5 2.4e-28 98.6 0.5 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EDP44648.1 - 7.2e-22 77.8 3.8 1.7e-18 67.0 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EDP44648.1 - 8.5e-16 58.1 2.2 1.5e-13 50.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDP44648.1 - 1.1e-08 34.2 5.1 0.00099 17.9 1.9 2.8 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 EDP44648.1 - 1.1e-07 31.6 0.1 1.9e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDP44648.1 - 9.2e-07 28.3 2.7 1.2e-05 24.7 0.6 2.6 3 0 0 3 3 3 1 FAD binding domain GIDA PF01134.22 EDP44648.1 - 0.00036 19.7 0.2 0.0011 18.2 0.1 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A K_oxygenase PF13434.6 EDP44648.1 - 0.00061 19.0 0.0 0.003 16.8 0.0 1.9 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EDP44648.1 - 0.00066 19.9 2.5 0.00066 19.9 2.5 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDP44648.1 - 0.0061 15.8 0.2 0.013 14.7 0.2 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_7 PF13241.6 EDP44648.1 - 0.026 15.0 0.1 4.1 7.9 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EDP44648.1 - 0.14 11.4 1.3 1.7 7.8 1.1 2.2 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 EDP44648.1 - 0.14 11.5 2.8 0.95 8.7 0.4 2.6 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EDP44648.1 - 0.16 11.2 1.3 0.25 10.6 0.0 1.9 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.18 EDP44648.1 - 2 8.3 5.4 2.1 8.2 0.0 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EDP44648.1 - 2.5 8.1 8.5 0.12 12.3 0.5 2.8 3 1 0 3 3 3 0 FAD-NAD(P)-binding TFIID-18kDa PF02269.16 EDP44649.1 - 6.8e-17 61.3 0.4 4.1e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 Transcription initiation factor IID, 18kD subunit RPAP1_C PF08620.10 EDP44650.1 - 4.9e-23 81.0 0.8 1.3e-22 79.7 0.8 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EDP44650.1 - 0.0024 17.6 0.1 0.0045 16.7 0.1 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.22 EDP44650.1 - 0.35 11.2 2.6 21 5.7 0.4 3.2 2 0 0 2 2 2 0 HEAT repeat TRAPPC10 PF12584.8 EDP44651.1 - 1.5e-16 60.5 0.1 4.3e-16 59.0 0.1 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 KAAG1 PF15354.6 EDP44651.1 - 0.061 13.9 0.5 7.2 7.2 0.0 3.2 2 1 1 3 3 3 0 Kidney-associated antigen 1 Proteasome PF00227.26 EDP44652.1 - 4.8e-55 186.0 0.1 6e-55 185.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EDP44652.1 - 8.5e-14 50.9 0.0 1.9e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ENTH PF01417.20 EDP44653.1 - 8.5e-29 100.1 0.0 1.3e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EDP44653.1 - 0.027 13.5 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 ANTH domain DUF5102 PF17104.5 EDP44653.1 - 7.2 6.6 7.8 4.9 7.1 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) Peptidase_M50 PF02163.22 EDP44654.1 - 1.9e-05 24.1 0.5 2.5e-05 23.7 0.5 1.1 1 0 0 1 1 1 1 Peptidase family M50 PAP_central PF04928.17 EDP44655.1 - 1.8e-112 374.3 0.0 2.3e-112 374.0 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EDP44655.1 - 6.8e-47 159.3 0.0 1.1e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EDP44655.1 - 1.5e-12 47.7 0.0 3.3e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DNA_pol_B_palm PF14792.6 EDP44655.1 - 0.003 17.8 0.0 0.059 13.6 0.0 2.6 3 0 0 3 3 3 1 DNA polymerase beta palm Polbeta PF18765.1 EDP44655.1 - 0.057 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase zf-C3HC4_3 PF13920.6 EDP44659.1 - 1.7e-08 34.2 6.6 1.1e-05 25.2 3.2 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EDP44659.1 - 6.8e-07 29.2 6.4 3.3e-06 27.0 4.4 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EDP44659.1 - 1.6e-06 27.9 6.4 2.9e-06 27.1 3.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP44659.1 - 8.1e-06 26.1 8.0 3.9e-05 23.9 3.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP44659.1 - 8.4e-06 25.5 6.6 1e-05 25.3 2.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EDP44659.1 - 1.6e-05 24.8 6.4 4e-05 23.5 3.0 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EDP44659.1 - 0.0024 17.7 10.4 0.026 14.4 7.4 2.7 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 DUF1644 PF07800.12 EDP44659.1 - 0.38 10.8 0.0 0.38 10.8 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1644) Peptidase_M16_C PF05193.21 EDP44660.1 - 7.4e-41 140.2 0.0 1e-37 130.0 0.0 2.7 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDP44660.1 - 2.3e-29 102.3 0.3 6.1e-29 100.9 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 EDP44660.1 - 0.042 13.0 0.1 0.073 12.2 0.1 1.3 1 0 0 1 1 1 0 Peptidase M16C associated Metal_resist PF13801.6 EDP44660.1 - 0.059 13.6 0.4 0.13 12.5 0.4 1.5 1 0 0 1 1 1 0 Heavy-metal resistance PhageMin_Tail PF10145.9 EDP44660.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Phage-related minor tail protein ATP-synt_C PF00137.21 EDP44661.1 - 6.6e-34 116.1 35.2 5.1e-22 78.0 15.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C IncD PF17628.2 EDP44661.1 - 7 6.4 7.3 6.4 6.6 5.6 1.7 1 1 0 1 1 1 0 Inclusion membrane protein D Aconitase PF00330.20 EDP44662.1 - 3.9e-162 540.4 0.0 5.9e-162 539.8 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDP44662.1 - 4.1e-41 140.4 0.0 8.7e-41 139.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain RNase_PH PF01138.21 EDP44663.1 - 1.4e-14 54.7 0.0 2.5e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EDP44663.1 - 0.00031 20.7 0.0 0.00065 19.7 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 FHA PF00498.26 EDP44664.1 - 3e-09 37.1 0.2 6.4e-09 36.0 0.2 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EDP44664.1 - 0.00033 20.9 0.1 0.00085 19.6 0.1 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Homeobox_KN PF05920.11 EDP44665.1 - 6e-18 64.5 0.2 2.3e-17 62.6 0.1 2.1 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EDP44665.1 - 0.00076 19.3 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain Ribosomal_L23eN PF03939.13 EDP44666.1 - 9.2e-22 77.0 9.6 2.1e-21 75.8 9.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EDP44666.1 - 2.4e-14 53.4 1.4 2.4e-14 53.4 1.4 2.1 2 2 0 2 2 2 1 Ribosomal protein L23 Abhydrolase_1 PF00561.20 EDP44667.1 - 2.9e-09 37.0 0.0 5.4e-07 29.5 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP44667.1 - 5.1e-09 37.1 0.6 4.6e-08 33.9 0.0 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP44667.1 - 3.7e-05 23.1 0.1 0.0021 17.4 0.0 2.7 3 1 0 3 3 3 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EDP44667.1 - 0.064 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Dynamin_N PF00350.23 EDP44668.1 - 6.3e-20 71.9 0.0 2.3e-19 70.1 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EDP44668.1 - 1.4e-11 44.4 0.0 1.5e-10 41.2 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDP44668.1 - 1.3e-08 34.6 0.0 4e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDP44668.1 - 1.5e-05 24.9 0.3 0.052 13.5 0.1 3.1 3 0 0 3 3 3 2 RsgA GTPase DUF2533 PF10752.9 EDP44668.1 - 0.00013 22.3 1.6 0.0076 16.7 0.0 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2533) Gtr1_RagA PF04670.12 EDP44668.1 - 0.00013 21.4 0.3 0.00035 20.0 0.3 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 EDP44668.1 - 0.00021 20.9 0.1 0.027 14.1 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 EDP44668.1 - 0.0019 17.7 0.2 3.8 7.0 0.1 3.1 3 0 0 3 3 3 2 Ferrous iron transport protein B Roc PF08477.13 EDP44668.1 - 0.0019 18.4 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EDP44668.1 - 0.0059 16.3 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Arf PF00025.21 EDP44668.1 - 0.0075 15.7 0.4 4.6 6.7 0.0 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family IIGP PF05049.13 EDP44668.1 - 0.021 13.9 0.1 0.056 12.5 0.0 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Septin PF00735.18 EDP44668.1 - 0.021 14.1 0.0 0.059 12.6 0.0 1.7 2 0 0 2 2 2 0 Septin TsaE PF02367.17 EDP44668.1 - 0.044 13.8 0.0 0.094 12.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF842 PF05811.13 EDP44668.1 - 0.049 13.3 0.4 2.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) PIN_10 PF18478.1 EDP44668.1 - 0.14 12.4 0.1 0.43 10.8 0.1 1.9 1 0 0 1 1 1 0 PIN like domain UBX PF00789.20 EDP44669.1 - 0.053 13.7 0.0 0.072 13.3 0.0 1.2 1 0 0 1 1 1 0 UBX domain Formyl_trans_N PF00551.19 EDP44670.1 - 2e-36 125.4 0.0 2.5e-18 66.5 0.1 2.4 2 0 0 2 2 2 2 Formyl transferase ABC_membrane PF00664.23 EDP44671.1 - 7.4e-113 376.7 30.3 1e-61 209.0 16.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDP44671.1 - 7.1e-71 237.1 0.0 1.5e-34 119.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDP44671.1 - 1e-13 51.2 0.1 0.00058 19.4 0.0 3.9 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EDP44671.1 - 9.7e-08 31.2 0.5 0.003 16.4 0.1 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 EDP44671.1 - 5.5e-07 30.1 1.4 0.012 16.0 0.0 3.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EDP44671.1 - 8e-07 29.4 1.2 0.015 15.6 0.1 3.7 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EDP44671.1 - 4e-06 26.8 0.0 0.03 14.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EDP44671.1 - 5.1e-06 26.1 2.6 0.0042 16.8 0.1 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EDP44671.1 - 9.4e-06 25.6 0.1 0.38 10.5 0.0 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EDP44671.1 - 1e-05 25.5 0.0 0.055 13.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EDP44671.1 - 2.2e-05 24.4 0.2 2.1 8.4 0.0 4.0 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EDP44671.1 - 2.7e-05 24.4 0.1 0.05 13.7 0.0 3.1 3 0 0 3 3 3 2 Helicase HerA, central domain AAA_30 PF13604.6 EDP44671.1 - 0.0001 22.1 0.0 0.3 10.8 0.0 3.3 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.12 EDP44671.1 - 0.00015 21.1 0.0 0.081 12.2 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA PF00004.29 EDP44671.1 - 0.00015 22.2 0.1 3.7 8.0 0.0 3.9 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 EDP44671.1 - 0.00094 18.4 0.0 1.1 8.3 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_25 PF13481.6 EDP44671.1 - 0.0028 17.2 0.0 1.5 8.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain Rad17 PF03215.15 EDP44671.1 - 0.0033 17.4 0.1 1.2 9.0 0.1 3.0 2 1 0 2 2 2 1 Rad17 P-loop domain SbcCD_C PF13558.6 EDP44671.1 - 0.0035 17.6 6.3 1.8 8.9 0.6 4.4 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EDP44671.1 - 0.0036 17.8 0.3 0.22 12.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDP44671.1 - 0.015 14.8 0.0 7.2 6.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 EDP44671.1 - 0.02 15.1 0.2 4.8 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain APS_kinase PF01583.20 EDP44671.1 - 0.025 14.5 0.1 3.9 7.3 0.0 2.8 3 0 0 3 3 2 0 Adenylylsulphate kinase AAA_18 PF13238.6 EDP44671.1 - 0.034 14.7 0.0 8.1 7.0 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 EDP44671.1 - 0.048 13.4 0.0 6.7 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDP44671.1 - 0.053 13.9 0.0 18 5.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase PRK PF00485.18 EDP44671.1 - 0.056 13.2 0.0 5.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF815 PF05673.13 EDP44671.1 - 0.058 12.5 0.0 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 EDP44671.1 - 0.19 11.9 0.1 17 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_7 PF13499.6 EDP44672.1 - 8.4e-10 39.0 0.1 2.1e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EDP44672.1 - 6.8e-08 31.8 0.0 0.014 15.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EDP44672.1 - 4.2e-07 29.0 0.0 0.00093 18.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 EDP44672.1 - 1.4e-06 27.5 0.0 0.0002 20.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EDP44672.1 - 0.0006 19.6 0.1 0.017 15.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Glycos_transf_3 PF00591.21 EDP44673.1 - 2.3e-66 224.0 0.0 2.3e-62 210.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EDP44673.1 - 0.0025 17.6 0.1 0.0058 16.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain EF-hand_1 PF00036.32 EDP44674.1 - 2.6e-25 86.1 6.1 9e-08 31.1 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EDP44674.1 - 5.6e-25 87.6 0.7 4e-15 56.0 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EDP44674.1 - 2.6e-21 73.7 2.1 1.2e-06 27.9 0.0 5.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EDP44674.1 - 8.7e-15 54.3 5.8 1.1e-06 28.4 0.2 3.9 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EDP44674.1 - 1.3e-13 49.7 7.9 0.00015 21.1 0.1 4.6 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 EDP44674.1 - 6.1e-09 35.8 1.4 0.0086 16.0 0.0 3.7 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EDP44674.1 - 0.00036 20.8 1.1 0.11 12.8 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EDP44674.1 - 0.0021 18.3 0.4 4.7 7.6 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 EDP44674.1 - 0.0071 16.3 0.8 19 5.1 0.0 3.4 2 1 1 3 3 3 0 Caleosin related protein EF-hand_14 PF17959.1 EDP44674.1 - 0.05 13.9 0.3 1.7 9.1 0.0 2.8 3 1 0 3 3 3 0 EF-hand domain DUF4746 PF15928.5 EDP44674.1 - 0.12 11.7 1.2 0.2 11.0 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) AAA_11 PF13086.6 EDP44675.1 - 9.2e-65 219.0 0.0 1.9e-64 217.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EDP44675.1 - 7.4e-58 195.5 0.0 1.4e-57 194.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP44675.1 - 3.9e-12 46.3 1.7 6.6e-08 32.5 0.1 3.1 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EDP44675.1 - 4.1e-11 43.1 0.2 0.00085 19.1 0.1 3.2 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EDP44675.1 - 5.4e-08 33.3 0.0 1.8e-06 28.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 EDP44675.1 - 0.00024 20.7 0.0 0.00048 19.7 0.0 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 EDP44675.1 - 0.00051 19.8 0.0 0.0014 18.4 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 EDP44675.1 - 0.00059 20.3 0.6 0.0018 18.7 0.1 2.1 2 0 0 2 2 1 1 AAA ATPase domain DUF2075 PF09848.9 EDP44675.1 - 0.00062 19.1 0.0 0.23 10.6 0.0 3.0 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EDP44675.1 - 0.00077 19.7 0.3 0.0076 16.5 0.1 2.9 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EDP44675.1 - 0.0024 17.8 0.0 0.024 14.5 0.0 2.4 3 0 0 3 3 3 1 Helicase AAA PF00004.29 EDP44675.1 - 0.0024 18.3 0.0 0.0079 16.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EDP44675.1 - 0.0024 17.9 0.0 0.046 13.7 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 EDP44675.1 - 0.0038 16.8 0.0 0.013 15.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP44675.1 - 0.0052 17.0 0.1 0.016 15.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 EDP44675.1 - 0.0067 15.8 0.2 0.024 14.0 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family Mg_chelatase PF01078.21 EDP44675.1 - 0.0081 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EDP44675.1 - 0.01 15.7 0.0 0.044 13.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 EDP44675.1 - 0.042 12.9 0.0 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 EDP44675.1 - 0.047 13.1 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 EDP44675.1 - 0.075 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EDP44675.1 - 0.097 12.4 0.0 0.27 10.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EDP44675.1 - 0.15 12.5 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EDP44675.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_7 PF12775.7 EDP44675.1 - 0.16 11.5 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region UvrD_C PF13361.6 EDP44675.1 - 0.27 10.6 0.3 1.7 8.0 0.2 2.0 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain ETF PF01012.21 EDP44676.1 - 1.6e-42 145.4 3.2 2.2e-42 145.0 3.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EFG_C PF00679.24 EDP44676.1 - 0.057 13.5 0.0 0.44 10.6 0.0 2.1 2 0 0 2 2 2 0 Elongation factor G C-terminus Mito_carr PF00153.27 EDP44677.1 - 7.2e-28 96.4 0.1 8.9e-16 57.6 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein ALG11_N PF15924.5 EDP44678.1 - 5.1e-73 245.6 0.0 7.2e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EDP44678.1 - 1.6e-14 53.8 0.0 2.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EDP44678.1 - 4.5e-06 27.1 0.0 9.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EDP44678.1 - 0.046 13.7 0.8 0.11 12.4 0.8 1.7 1 1 0 1 1 1 0 Glycosyltransferase Family 4 PI3Ka PF00613.20 EDP44679.1 - 2e-44 151.2 1.0 3.2e-44 150.5 1.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EDP44679.1 - 5.6e-44 150.8 0.0 1.2e-30 107.1 0.0 2.6 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EDP44679.1 - 1.6e-27 96.1 0.0 2.8e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EDP44679.1 - 0.017 14.5 0.2 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) tRNA_int_endo PF01974.17 EDP44680.1 - 5.5e-16 58.4 0.0 9.8e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PGM_PMM_I PF02878.16 EDP44681.1 - 1.1e-35 122.4 0.1 1.8e-35 121.7 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EDP44681.1 - 1.2e-27 96.4 0.0 2.4e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EDP44681.1 - 9.2e-16 58.3 0.0 2.4e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EDP44681.1 - 3.3e-06 27.2 0.0 9e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ADH_zinc_N PF00107.26 EDP44682.1 - 4.2e-27 94.7 0.0 7e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EDP44682.1 - 1.9e-10 41.9 0.0 8.1e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP44682.1 - 2.8e-06 27.2 0.0 0.00022 21.1 0.0 2.5 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain PALP PF00291.25 EDP44682.1 - 0.025 14.0 0.1 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Pkinase PF00069.25 EDP44683.1 - 4.5e-71 239.3 0.0 5.6e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44683.1 - 1.7e-30 106.2 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EDP44683.1 - 4.4e-12 46.5 0.8 4.4e-12 46.5 0.8 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EDP44683.1 - 2.1e-05 23.7 0.0 2.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDP44683.1 - 0.0022 17.4 0.0 0.0062 15.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDP44683.1 - 0.0087 15.7 0.0 0.25 10.9 0.0 2.1 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EDP44683.1 - 0.022 14.1 0.1 0.055 12.8 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP44683.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NOT2_3_5 PF04153.18 EDP44684.1 - 6.6e-34 116.8 0.7 1e-33 116.2 0.7 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Chorismate_synt PF01264.21 EDP44686.1 - 2.8e-142 473.3 0.0 3.2e-142 473.1 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Gti1_Pac2 PF09729.9 EDP44688.1 - 6.5e-35 120.8 0.3 1.9e-29 103.0 0.0 2.4 1 1 1 2 2 2 2 Gti1/Pac2 family Histone PF00125.24 EDP44689.1 - 1.7e-42 144.9 2.0 2.1e-42 144.6 2.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EDP44689.1 - 0.0003 20.9 0.0 0.00049 20.2 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EDP44689.1 - 0.0015 18.9 0.1 0.0025 18.2 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EDP44689.1 - 0.011 16.0 0.2 0.073 13.4 0.2 2.1 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EDP44689.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CDC73_C PF05179.14 EDP44690.1 - 1.2e-36 125.7 0.0 5.4e-30 104.2 0.0 2.3 2 0 0 2 2 2 2 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 EDP44690.1 - 0.029 13.7 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal NUP50 PF08911.11 EDP44690.1 - 0.1 13.3 0.9 1.8 9.3 0.5 2.4 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) Oxidored_FMN PF00724.20 EDP44692.1 - 9.4e-57 192.8 0.0 1.2e-56 192.5 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family COX7a PF02238.15 EDP44693.1 - 2.8e-17 62.9 0.7 3.2e-17 62.7 0.7 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Chs7 PF12271.8 EDP44694.1 - 4.4e-79 265.8 22.5 5.1e-79 265.6 22.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Septin PF00735.18 EDP44695.1 - 9.6e-100 333.5 0.1 1.9e-99 332.5 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EDP44695.1 - 1.4e-06 28.3 0.0 2.9e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EDP44695.1 - 5.5e-05 23.3 0.0 0.00014 22.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EDP44695.1 - 0.00068 19.6 0.5 0.011 15.6 0.7 2.6 2 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EDP44695.1 - 0.00093 19.3 3.1 0.49 10.4 0.1 2.8 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 EDP44695.1 - 0.0028 17.0 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 EDP44695.1 - 0.0032 17.7 0.0 0.01 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain IIGP PF05049.13 EDP44695.1 - 0.0067 15.5 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Roc PF08477.13 EDP44695.1 - 0.0073 16.5 0.0 0.013 15.7 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EDP44695.1 - 0.011 15.3 0.0 0.059 12.9 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF87 PF01935.17 EDP44695.1 - 0.011 15.9 0.6 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EDP44695.1 - 0.027 13.8 0.5 0.063 12.6 0.3 1.7 1 1 1 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.6 EDP44695.1 - 0.059 13.6 1.6 0.29 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDP44695.1 - 0.074 13.5 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EDP44695.1 - 0.082 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EDP44695.1 - 0.088 13.2 0.1 0.21 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EDP44695.1 - 0.1 13.2 0.8 0.45 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP44695.1 - 0.12 12.9 0.1 0.29 11.7 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_19 PF13245.6 EDP44695.1 - 0.17 12.2 0.0 1.8 8.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Ras PF00071.22 EDP44695.1 - 0.21 11.2 0.3 0.43 10.2 0.0 1.6 2 0 0 2 2 2 0 Ras family AAA_23 PF13476.6 EDP44695.1 - 1.4 9.4 5.8 20 5.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain 2-Hacid_dh PF00389.30 EDP44696.1 - 0.0017 18.0 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 EDP44697.1 - 2.8e-48 163.6 0.0 3.8e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EDP44697.1 - 6.6e-05 23.1 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EDP44697.1 - 0.012 15.5 0.2 0.63 9.9 0.1 2.8 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EDP44697.1 - 0.031 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MRP-S25 PF13741.6 EDP44698.1 - 3.5e-12 46.4 2.0 4.8e-12 45.9 2.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 Maf PF02545.14 EDP44699.1 - 1.4e-38 132.4 0.0 1.6e-38 132.2 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein SRP68 PF16969.5 EDP44700.1 - 2e-44 152.6 22.1 4.7e-43 148.0 22.1 2.4 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 Zn_clus PF00172.18 EDP44701.1 - 9.9e-06 25.6 9.8 1.7e-05 24.9 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3038 PF11237.8 EDP44701.1 - 0.00083 19.4 0.1 0.0025 17.9 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3038) Fungal_trans PF04082.18 EDP44701.1 - 0.0082 15.2 0.1 0.015 14.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain HisKA PF00512.25 EDP44701.1 - 0.06 13.4 0.2 0.41 10.7 0.0 2.5 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Cation_ATPase_C PF00689.21 EDP44702.1 - 1.8e-45 154.9 2.7 1.8e-45 154.9 2.7 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EDP44702.1 - 4.7e-39 133.8 0.4 4.7e-39 133.8 0.4 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EDP44702.1 - 1.5e-19 69.9 0.0 8.1e-19 67.5 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EDP44702.1 - 1.5e-12 48.2 0.3 2.2e-11 44.5 0.3 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EDP44702.1 - 2e-12 46.6 0.1 7.3e-12 44.8 0.1 2.1 1 1 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EDP44702.1 - 0.003 17.3 1.1 0.0045 16.8 0.5 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase MNHE PF01899.16 EDP44702.1 - 0.065 13.0 1.8 0.63 9.8 0.1 2.9 2 1 0 2 2 2 0 Na+/H+ ion antiporter subunit WD40 PF00400.32 EDP44703.1 - 7.7e-41 137.3 16.0 1.2e-07 32.3 2.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44703.1 - 1.1e-14 54.5 0.8 0.0041 17.4 0.0 5.2 4 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP44703.1 - 0.0011 18.0 0.0 3.7 6.4 0.0 4.1 2 1 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein CTK3 PF12243.8 EDP44704.1 - 1.6e-28 99.1 0.2 2e-28 98.8 0.2 1.1 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 DUF1749 PF08538.10 EDP44705.1 - 0.0079 15.3 0.0 0.032 13.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) RRM_1 PF00076.22 EDP44706.1 - 1.3e-60 201.2 0.0 2.9e-18 65.5 0.0 5.7 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP44706.1 - 3.8e-05 23.7 0.0 0.14 12.3 0.0 3.7 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 EDP44706.1 - 0.0002 21.4 0.5 0.7 10.0 0.0 4.2 4 1 1 5 5 5 1 RNA binding motif RRM_occluded PF16842.5 EDP44706.1 - 0.0017 18.2 0.0 11 5.9 0.0 3.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EDP44706.1 - 0.0031 17.5 0.0 3.3 7.8 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 EDP44706.1 - 0.0037 17.1 0.1 1.6 8.5 0.0 3.5 3 1 1 4 4 4 1 Rrp7 RRM-like N-terminal domain Phosphoprotein PF00922.17 EDP44706.1 - 0.0064 16.1 2.4 0.017 14.7 2.4 1.7 1 0 0 1 1 1 1 Vesiculovirus phosphoprotein RRM_8 PF11835.8 EDP44706.1 - 0.023 14.9 0.0 0.37 11.0 0.0 2.7 2 0 0 2 2 2 0 RRM-like domain ELFV_dehydrog PF00208.21 EDP44707.1 - 2.9e-57 194.2 0.0 6.5e-57 193.0 0.0 1.6 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EDP44707.1 - 4.9e-20 70.8 0.0 5.4e-12 44.1 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EDP44707.1 - 0.11 12.4 0.0 0.55 10.1 0.0 2.1 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Transket_pyr PF02779.24 EDP44708.1 - 1e-62 211.0 0.0 1.6e-62 210.3 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EDP44708.1 - 1.7e-61 207.8 0.0 2.4e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EDP44708.1 - 3.4e-44 150.2 0.0 6.3e-44 149.3 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EDP44708.1 - 5.8e-18 64.2 1.2 1.5e-17 62.9 1.2 1.8 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus TetR_N PF00440.23 EDP44708.1 - 0.16 11.8 0.0 11 5.9 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Synaptobrevin PF00957.21 EDP44709.1 - 2e-31 107.6 1.3 2.5e-31 107.3 1.3 1.1 1 0 0 1 1 1 1 Synaptobrevin Baculo_F PF12259.8 EDP44709.1 - 0.034 12.7 0.2 0.039 12.5 0.2 1.1 1 0 0 1 1 1 0 Baculovirus F protein RSN1_TM PF13967.6 EDP44709.1 - 0.065 13.0 0.1 0.091 12.5 0.1 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport ODV-E18 PF10717.9 EDP44709.1 - 0.067 13.1 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ECSCR PF15820.5 EDP44709.1 - 0.079 12.8 1.9 0.18 11.6 0.2 2.0 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Orf78 PF06024.12 EDP44709.1 - 0.1 12.9 2.0 0.32 11.3 1.8 1.8 1 1 1 2 2 2 0 Orf78 (ac78) DUF3671 PF12420.8 EDP44709.1 - 0.12 12.4 0.2 0.18 11.9 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function Ribosomal_L22 PF00237.19 EDP44710.1 - 1.7e-36 124.6 0.0 2.9e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF1749 PF08538.10 EDP44711.1 - 1.7e-52 178.4 0.0 3e-52 177.6 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EDP44711.1 - 0.00036 21.2 0.2 0.00044 20.9 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP44711.1 - 0.024 13.9 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EDP44711.1 - 0.081 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase enzyme PTPlike_phytase PF14566.6 EDP44712.1 - 1.2e-137 454.3 1.7 1.5e-49 168.1 0.2 3.3 3 0 0 3 3 3 3 Inositol hexakisphosphate DSPc PF00782.20 EDP44712.1 - 5.9e-07 29.4 0.1 0.61 9.9 0.0 4.2 4 0 0 4 4 4 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDP44712.1 - 6e-06 26.0 0.2 1.1 8.8 0.0 3.2 3 0 0 3 3 3 3 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EDP44712.1 - 0.00018 21.5 4.2 0.17 11.8 0.3 3.3 4 0 0 4 4 4 2 Tyrosine phosphatase family Chitin_synth_1 PF01644.17 EDP44713.1 - 2e-74 249.0 0.0 3.3e-74 248.3 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EDP44713.1 - 4.2e-24 84.3 0.0 8.4e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EDP44713.1 - 2.6e-19 69.2 13.6 6.4e-18 64.7 3.9 2.3 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EDP44713.1 - 0.00052 20.0 20.1 0.00052 20.0 20.1 2.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 DUF1218 PF06749.12 EDP44713.1 - 0.15 12.6 0.2 0.15 12.6 0.2 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1218) EF-hand_4 PF12763.7 EDP44714.1 - 2.3e-15 56.4 0.0 4.6e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EDP44714.1 - 3.7e-08 32.9 0.6 7.5e-08 32.0 0.6 1.6 1 0 0 1 1 1 1 WH2 motif Trypan_PARP PF05887.11 EDP44714.1 - 8.1e-07 29.1 45.5 8.1e-07 29.1 45.5 4.3 2 1 2 5 5 5 1 Procyclic acidic repetitive protein (PARP) SH3_9 PF14604.6 EDP44714.1 - 0.0048 16.7 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_7 PF13499.6 EDP44714.1 - 0.036 14.5 0.0 0.38 11.2 0.0 2.5 1 1 2 3 3 3 0 EF-hand domain pair Sugarporin_N PF11471.8 EDP44714.1 - 0.18 11.8 14.8 0.24 11.4 3.5 2.8 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Rx_N PF18052.1 EDP44714.1 - 0.65 10.3 3.7 1.7 9.0 3.7 1.7 1 0 0 1 1 1 0 Rx N-terminal domain WD40 PF00400.32 EDP44715.1 - 8.4e-20 70.7 20.6 0.00026 21.7 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF3337 PF11816.8 EDP44715.1 - 5.1e-18 65.5 0.0 8.9e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) Nup160 PF11715.8 EDP44715.1 - 0.0087 14.7 1.5 0.19 10.3 0.2 3.2 3 1 1 4 4 4 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDP44715.1 - 0.15 12.4 0.4 0.69 10.3 0.0 2.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Cpn60_TCP1 PF00118.24 EDP44716.1 - 3e-131 438.5 0.3 3.6e-131 438.2 0.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase PF00069.25 EDP44717.1 - 4.2e-63 213.2 0.7 4.2e-58 196.8 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44717.1 - 1.1e-35 123.2 0.3 6.4e-32 110.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase KA1 PF02149.19 EDP44717.1 - 7.6e-17 60.8 0.1 1.5e-16 59.9 0.1 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.14 EDP44717.1 - 9.8e-07 28.3 0.1 1.7e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EDP44717.1 - 1.6e-05 24.3 0.0 2.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDP44717.1 - 1.7e-05 23.9 0.0 2.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP44717.1 - 0.017 15.1 0.4 0.067 13.1 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EDP44717.1 - 0.068 12.8 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 RIO1 family ABC1 PF03109.16 EDP44717.1 - 0.19 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Cyt-b5 PF00173.28 EDP44718.1 - 1.1e-23 83.1 0.1 1.2e-23 83.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Jiv90 PF14901.6 EDP44718.1 - 0.16 12.1 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone GTP_cyclohydroI PF01227.22 EDP44719.1 - 2.4e-74 248.6 0.0 2.8e-74 248.4 0.0 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EDP44719.1 - 0.00039 20.5 0.0 0.0011 19.0 0.0 1.7 2 0 0 2 2 2 1 QueF-like protein HATPase_c_2 PF13581.6 EDP44719.1 - 0.082 12.9 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Ribosomal_L14 PF00238.19 EDP44720.1 - 1.1e-35 122.4 0.0 1.3e-35 122.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Nucleopor_Nup85 PF07575.13 EDP44721.1 - 4.8e-70 236.7 0.0 2.6e-69 234.3 0.0 2.0 1 1 0 1 1 1 1 Nup85 Nucleoporin CdiI_2 PF18593.1 EDP44721.1 - 0.095 13.4 0.0 0.28 11.9 0.0 1.8 1 0 0 1 1 1 0 CdiI immunity protein HA2 PF04408.23 EDP44722.1 - 3.6e-27 94.8 0.0 6.4e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDP44722.1 - 4.5e-20 71.8 0.0 1.7e-19 70.0 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDP44722.1 - 7.6e-12 45.6 0.0 2.6e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ABC_tran PF00005.27 EDP44723.1 - 0.0033 17.9 0.0 0.015 15.9 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 EDP44723.1 - 0.0055 17.0 0.1 0.013 15.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EDP44723.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 EDP44723.1 - 0.02 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 EDP44723.1 - 0.029 13.8 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 EDP44723.1 - 0.092 11.8 0.1 0.1 11.6 0.1 1.2 1 1 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EDP44723.1 - 0.1 12.5 0.3 0.37 10.7 0.0 1.8 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EDP44723.1 - 0.11 13.0 0.8 0.11 13.0 0.8 2.0 1 1 1 2 2 2 0 AAA domain AAA_21 PF13304.6 EDP44723.1 - 0.35 10.6 1.1 5 6.9 0.3 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system WD40 PF00400.32 EDP44724.1 - 3e-11 43.7 2.0 0.004 18.0 0.5 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44724.1 - 0.0016 18.7 0.2 0.0033 17.7 0.1 1.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP44724.1 - 0.024 13.6 0.0 0.72 8.8 0.0 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoside_tran PF01733.18 EDP44727.1 - 1.8e-18 67.0 16.1 1.1e-16 61.1 9.7 2.9 2 1 0 2 2 2 2 Nucleoside transporter Acyl_transf_1 PF00698.21 EDP44728.1 - 3.7e-12 46.4 0.5 1e-10 41.6 0.1 3.1 3 1 0 3 3 3 1 Acyl transferase domain EMP24_GP25L PF01105.24 EDP44729.1 - 1e-15 58.2 0.4 1.2e-15 58.0 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD tRNA-synt_1b PF00579.25 EDP44730.1 - 6e-62 209.6 0.0 3.5e-61 207.1 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Glyoxalase PF00903.25 EDP44731.1 - 9.6e-16 58.1 0.0 1.2e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EDP44731.1 - 2.7e-06 27.6 0.0 4.1e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EDP44731.1 - 0.00043 21.1 0.0 0.00056 20.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EDP44731.1 - 0.039 14.1 0.0 0.048 13.8 0.0 1.4 1 1 0 1 1 1 0 Glyoxalase-like domain NIL PF09383.10 EDP44731.1 - 0.079 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NIL domain zf-C2H2_aberr PF17017.5 EDP44732.1 - 6.3e-05 23.2 3.3 0.1 12.8 0.3 2.4 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 EDP44732.1 - 0.0091 16.4 13.5 0.13 12.7 0.6 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDP44732.1 - 0.094 13.2 3.9 4.8 7.8 1.0 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EDP44732.1 - 3.8 8.6 14.2 9.5 7.4 0.4 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger GPI2 PF06432.11 EDP44733.1 - 4.2e-52 177.3 7.2 4.9e-52 177.1 7.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Abhydrolase_3 PF07859.13 EDP44734.1 - 2.3e-18 66.8 0.0 4.4e-18 65.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDP44734.1 - 7.3e-16 58.0 0.0 1.1e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 EDP44734.1 - 0.11 13.1 4.4 0.24 12.0 4.4 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 EDP44734.1 - 0.2 11.2 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) UCH PF00443.29 EDP44735.1 - 4.2e-31 108.4 0.1 5.9e-31 107.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EDP44735.1 - 4.7e-11 42.8 0.8 5.9e-11 42.5 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NopRA1 PF16201.5 EDP44736.1 - 2e-61 207.1 0.4 5.7e-61 205.6 0.4 1.9 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 Npa1 PF11707.8 EDP44736.1 - 3e-55 188.0 0.0 6.2e-55 186.9 0.0 1.4 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal ThiF PF00899.21 EDP44737.1 - 1.1e-19 70.8 0.0 2e-19 69.9 0.0 1.4 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EDP44737.1 - 0.00027 21.1 0.1 6.4 7.1 0.0 3.8 3 0 0 3 3 3 3 Ubiquitin-activating enzyme E1 four-helix bundle DnaJ-X PF14308.6 EDP44738.1 - 1.7e-33 115.9 1.7 1.7e-33 115.9 1.7 1.8 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EDP44738.1 - 2.7e-26 91.5 0.7 7.4e-26 90.1 0.7 1.8 1 0 0 1 1 1 1 DnaJ domain DUF3631 PF12307.8 EDP44738.1 - 0.098 12.9 2.1 1.1 9.5 1.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3631) TFIIS_M PF07500.14 EDP44739.1 - 4.3e-30 104.5 1.3 4.3e-30 104.5 1.3 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EDP44739.1 - 1e-19 70.1 8.5 4e-19 68.2 8.0 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EDP44739.1 - 7.2e-13 48.3 2.1 1.3e-12 47.6 0.8 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.8 EDP44739.1 - 0.11 12.2 0.1 0.34 10.6 0.1 1.9 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain ATP11 PF06644.11 EDP44739.1 - 5.2 6.8 11.0 0.55 10.0 3.8 2.2 2 0 0 2 2 2 0 ATP11 protein Cytochrom_NNT PF03264.14 EDP44739.1 - 8.9 6.0 11.3 0.61 9.8 5.2 1.9 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region CBF PF03914.17 EDP44740.1 - 1.1e-50 172.0 0.0 1.1e-50 172.0 0.0 3.1 3 0 0 3 3 3 1 CBF/Mak21 family Cnd1 PF12717.7 EDP44740.1 - 0.0014 18.7 0.4 0.024 14.7 0.4 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 GCD14 PF08704.10 EDP44741.1 - 1.9e-57 194.8 4.6 5.5e-46 157.3 0.6 3.1 2 1 1 3 3 3 3 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EDP44741.1 - 0.0011 18.8 0.1 0.13 12.1 0.0 2.4 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_24 PF13578.6 EDP44741.1 - 0.023 15.7 0.0 0.069 14.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EDP44741.1 - 0.08 13.7 0.3 7.8 7.3 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain Exo_endo_phos PF03372.23 EDP44742.1 - 2.1e-12 47.1 0.0 9.1e-12 45.0 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Metallophos PF00149.28 EDP44743.1 - 8.5e-09 36.2 0.0 1.7e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase UBX PF00789.20 EDP44744.1 - 3.6e-07 30.3 0.0 1.5e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 UBX domain zf-C2H2_2 PF12756.7 EDP44744.1 - 0.028 14.7 0.3 0.056 13.8 0.1 1.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Goodbye PF17109.5 EDP44744.1 - 1.1 9.8 6.8 0.16 12.4 1.2 2.3 1 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain WD40 PF00400.32 EDP44745.1 - 1.1e-17 64.1 5.5 0.00076 20.2 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44745.1 - 1.8e-10 41.0 0.0 0.0011 19.2 0.0 4.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EDP44745.1 - 0.024 14.6 3.9 0.066 13.2 0.1 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EDP44745.1 - 0.025 13.6 0.1 5.1 6.0 0.0 3.1 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2844 PF11005.8 EDP44745.1 - 0.11 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2844) adh_short PF00106.25 EDP44747.1 - 8e-28 97.2 0.0 6.2e-21 74.8 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDP44747.1 - 3.5e-17 62.8 0.0 2.3e-13 50.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP44747.1 - 2e-08 34.3 0.0 3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDP44747.1 - 3.7e-05 23.3 0.0 4.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EDP44747.1 - 0.027 13.9 0.0 0.036 13.4 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDP44747.1 - 0.034 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 EDP44748.1 - 4.3e-26 91.6 0.0 3.6e-21 75.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EDP44748.1 - 8.6e-14 51.7 0.0 2.3e-11 43.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP44748.1 - 5.5e-08 32.9 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EDP44748.1 - 0.0024 17.4 0.0 0.0058 16.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Varsurf_PPLC PF03490.13 EDP44748.1 - 0.025 14.5 0.0 0.077 13.0 0.0 1.8 2 0 0 2 2 2 0 Variant-surface-glycoprotein phospholipase C GDP_Man_Dehyd PF16363.5 EDP44748.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EDP44748.1 - 0.083 12.0 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein Polysacc_synt_2 PF02719.15 EDP44748.1 - 0.13 11.3 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein SDH_alpha PF03313.15 EDP44750.1 - 6.4e-95 317.7 2.4 9.3e-95 317.2 2.4 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 EDP44750.1 - 1.7e-56 190.9 0.1 5.6e-56 189.2 0.0 1.9 2 0 0 2 2 2 1 Serine dehydratase beta chain Nucleoporin_FG PF13634.6 EDP44751.1 - 1.1e-36 125.5 134.5 1.3e-13 51.6 35.8 4.6 1 1 3 4 4 4 4 Nucleoporin FG repeat region Nup54 PF13874.6 EDP44751.1 - 2.8e-33 115.0 2.7 4.8e-33 114.2 2.7 1.3 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 HeLo PF14479.6 EDP44751.1 - 0.036 13.9 1.8 0.074 12.9 1.8 1.4 1 1 0 1 1 1 0 Prion-inhibition and propagation Cluap1 PF10234.9 EDP44751.1 - 0.047 13.1 3.3 0.074 12.4 3.3 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 Nup54_C PF18437.1 EDP44751.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain Baculo_PEP_C PF04513.12 EDP44751.1 - 0.47 10.5 1.9 22 5.1 0.0 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Inositol_P PF00459.25 EDP44752.1 - 3.7e-68 230.0 0.0 4.2e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family AAA_25 PF13481.6 EDP44753.1 - 0.00021 21.0 0.0 0.12 12.0 0.0 2.9 2 1 0 2 2 2 2 AAA domain ATPase PF06745.13 EDP44753.1 - 0.00076 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 EDP44753.1 - 0.0016 17.8 0.0 3.6 6.8 0.0 3.1 2 1 0 2 2 2 2 Rad51 AAA_33 PF13671.6 EDP44753.1 - 0.0093 16.1 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP44753.1 - 0.016 15.7 0.0 0.092 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EDP44753.1 - 0.042 14.3 0.0 0.12 12.8 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDP44753.1 - 0.051 13.5 0.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 EDP44753.1 - 0.14 11.8 0.0 1.6 8.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP44753.1 - 0.18 12.3 0.0 0.48 10.9 0.0 1.7 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 EDP44753.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Tyr_Deacylase PF02580.16 EDP44754.1 - 2.2e-52 177.4 0.0 2.5e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase GCIP PF13324.6 EDP44755.1 - 5.4e-09 36.0 11.2 2.3e-08 34.0 7.9 2.8 2 1 0 2 2 2 1 Grap2 and cyclin-D-interacting Adaptin_binding PF10199.9 EDP44755.1 - 0.048 14.3 0.9 0.12 12.9 0.9 1.8 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Ribosomal_60s PF00428.19 EDP44755.1 - 0.077 13.6 2.7 0.29 11.8 2.7 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein Eclosion PF04736.12 EDP44755.1 - 0.17 11.6 0.0 0.51 10.1 0.0 1.7 1 0 0 1 1 1 0 Eclosion hormone PMC2NT PF08066.12 EDP44755.1 - 3 8.6 10.2 9.9 6.9 0.8 3.3 3 1 0 3 3 3 0 PMC2NT (NUC016) domain DUF572 PF04502.13 EDP44756.1 - 1.3e-71 242.0 12.4 1.5e-71 241.8 12.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.14 EDP44756.1 - 0.0067 16.3 0.9 1.3 9.0 0.1 2.4 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif Hom_end_hint PF05203.16 EDP44756.1 - 0.056 13.4 0.6 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Hom_end-associated Hint zinc_ribbon_12 PF11331.8 EDP44756.1 - 0.12 12.2 0.3 10 6.0 0.1 2.6 2 0 0 2 2 2 0 Probable zinc-ribbon domain DUF3385 PF11865.8 EDP44756.1 - 0.88 9.5 3.4 0.4 10.6 0.5 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3385) Ribosomal_60s PF00428.19 EDP44756.1 - 8.4 7.1 9.0 1.2 9.8 1.1 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein LsmAD PF06741.13 EDP44757.1 - 1.3e-25 89.7 1.5 2.7e-25 88.7 1.5 1.6 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 EDP44757.1 - 5.8e-13 48.8 0.1 1.2e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 EDP44757.1 - 0.098 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 LSM domain HAS-barrel PF09378.10 EDP44757.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 HAS barrel domain MBF1 PF08523.10 EDP44757.1 - 0.21 12.1 3.0 0.72 10.3 0.0 3.2 3 0 0 3 3 3 0 Multiprotein bridging factor 1 Pept_tRNA_hydro PF01195.19 EDP44758.1 - 1e-25 90.6 0.0 2.2e-25 89.6 0.0 1.4 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase polyprenyl_synt PF00348.17 EDP44759.1 - 4.3e-65 219.3 0.0 1.1e-63 214.7 0.0 2.6 1 1 0 1 1 1 1 Polyprenyl synthetase RRM_1 PF00076.22 EDP44760.1 - 4.7e-11 42.3 0.0 5.3e-05 23.0 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EDP44760.1 - 4e-05 23.6 0.0 7.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif NUP50 PF08911.11 EDP44762.1 - 0.00061 20.4 0.0 0.00061 20.4 0.0 5.6 5 1 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) Pkinase PF00069.25 EDP44763.1 - 9e-52 176.0 0.0 1.7e-50 171.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44763.1 - 5.5e-26 91.4 0.0 3.1e-25 88.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 EDP44763.1 - 9e-09 35.4 0.0 0.009 16.1 0.0 2.9 3 0 0 3 3 3 2 PH domain Kinase-like PF14531.6 EDP44763.1 - 1.7e-05 24.3 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EDP44763.1 - 0.0007 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP44763.1 - 0.0052 16.7 1.8 0.01 15.8 0.1 2.4 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP44763.1 - 0.12 11.1 0.0 0.12 11.1 0.0 2.1 2 1 0 2 2 2 0 Fungal protein kinase DUF4112 PF13430.6 EDP44764.1 - 9.1e-27 93.4 0.1 1.3e-26 92.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF3972 PF13118.6 EDP44764.1 - 0.078 13.4 0.0 0.097 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Coprogen_oxidas PF01218.18 EDP44765.1 - 2.3e-115 384.4 0.0 3.3e-115 383.9 0.0 1.3 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase IMS_C PF11799.8 EDP44766.1 - 7.7e-06 26.6 0.1 1.4e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 EDP44766.1 - 0.039 13.5 2.1 0.039 13.5 2.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Vps36-NZF-N PF16988.5 EDP44766.1 - 0.07 12.5 0.3 0.14 11.5 0.3 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 EDP44766.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger IMS PF00817.20 EDP44767.1 - 7.8e-05 22.7 0.0 0.0084 16.1 0.0 2.2 1 1 1 2 2 2 2 impB/mucB/samB family SKIP_SNW PF02731.15 EDP44768.1 - 4.3e-68 228.0 3.0 4.3e-68 228.0 3.0 2.9 4 0 0 4 4 4 1 SKIP/SNW domain AA_permease PF00324.21 EDP44769.1 - 7e-129 430.5 33.1 8.4e-129 430.2 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDP44769.1 - 1.3e-36 126.4 38.1 1.6e-36 126.0 37.5 1.4 1 1 0 1 1 1 1 Amino acid permease DUF3169 PF11368.8 EDP44769.1 - 0.015 14.8 0.5 0.015 14.8 0.5 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3169) HRG PF16954.5 EDP44769.1 - 0.39 11.2 0.0 0.39 11.2 0.0 4.6 7 0 0 7 7 7 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene AA_permease PF00324.21 EDP44770.1 - 2.4e-132 441.9 34.5 3e-132 441.6 34.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDP44770.1 - 1.2e-42 146.3 38.6 1.6e-42 145.8 38.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDP44771.1 - 1.3e-115 386.8 36.5 1.5e-115 386.6 36.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDP44771.1 - 1.1e-38 133.2 38.8 1.4e-38 132.9 38.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EDP44772.1 - 4.9e-66 223.3 20.9 6.1e-66 223.0 20.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EDP44772.1 - 7.1e-25 87.7 19.3 8.5e-25 87.5 19.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2207 PF09972.9 EDP44772.1 - 0.59 8.8 3.9 13 4.3 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF373 PF04123.13 EDP44772.1 - 3.4 7.0 7.6 4.8 6.5 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Nucleoside_tran PF01733.18 EDP44773.1 - 0.00098 18.6 0.0 0.0011 18.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside transporter AA_permease PF00324.21 EDP44773.1 - 0.011 14.3 0.4 0.013 14.1 0.4 1.0 1 0 0 1 1 1 0 Amino acid permease AAA_12 PF13087.6 EDP44774.1 - 6.4e-47 159.7 0.0 1.1e-46 159.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 EDP44774.1 - 1.6e-39 135.8 0.0 2.6e-39 135.1 0.0 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 EDP44774.1 - 5.6e-31 108.3 6.0 3.3e-16 59.9 0.8 2.7 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EDP44774.1 - 6.3e-15 55.4 1.4 2.3e-14 53.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EDP44774.1 - 4e-10 40.2 3.3 2.1e-09 37.8 0.2 2.8 3 0 0 3 3 3 1 AAA domain UvrD_C_2 PF13538.6 EDP44774.1 - 4.6e-07 29.6 1.1 8.9e-07 28.6 0.3 2.0 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EDP44774.1 - 2.8e-06 27.3 2.0 0.3 10.8 0.1 3.6 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 EDP44774.1 - 9.6e-06 25.6 0.1 4.1e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 Helicase Cas_Cas4 PF01930.17 EDP44774.1 - 4e-05 23.8 0.2 0.00061 19.9 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function DUF83 AAA_16 PF13191.6 EDP44774.1 - 0.0042 17.5 0.3 0.031 14.7 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EDP44774.1 - 0.011 15.2 0.1 0.023 14.1 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI UvrD_C PF13361.6 EDP44774.1 - 0.015 14.7 0.0 0.54 9.6 0.0 2.4 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 EDP44774.1 - 0.02 15.2 0.8 5.8 7.2 0.1 3.7 4 1 0 4 4 3 0 AAA domain DUF87 PF01935.17 EDP44774.1 - 0.026 14.6 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain SRP54 PF00448.22 EDP44774.1 - 0.032 13.8 0.5 0.075 12.6 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDP44774.1 - 0.2 12.1 0.0 0.71 10.4 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Peptidase_M1 PF01433.20 EDP44775.1 - 2.8e-05 23.8 0.0 5.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Bromodomain PF00439.25 EDP44776.1 - 1e-54 182.5 0.4 2.2e-20 72.5 0.1 3.5 3 0 0 3 3 3 3 Bromodomain HEAT_2 PF13646.6 EDP44776.1 - 0.0048 17.2 12.1 1.2 9.6 0.1 4.8 5 0 0 5 5 5 2 HEAT repeats Pex14_N PF04695.13 EDP44777.1 - 0.033 14.8 0.1 0.033 14.8 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4436 PF14494.6 EDP44777.1 - 0.11 11.7 1.3 2.6 7.2 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4436) Asp PF00026.23 EDP44778.1 - 3.1e-63 214.1 7.3 3.9e-63 213.8 7.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDP44778.1 - 1.6e-11 44.8 4.2 2.4e-09 37.7 4.2 2.8 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EDP44778.1 - 3.2e-06 27.7 1.3 0.0015 19.1 0.1 3.1 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EDP44778.1 - 3.6e-05 24.3 0.5 0.008 16.7 0.0 3.5 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease CAF20 PF17052.5 EDP44778.1 - 0.079 13.1 1.2 0.17 12.0 0.8 1.7 1 1 0 1 1 1 0 Cap associated factor CarboxypepD_reg PF13620.6 EDP44778.1 - 0.11 12.8 0.4 1.1 9.5 0.0 2.7 3 1 0 3 3 3 0 Carboxypeptidase regulatory-like domain NTF2 PF02136.20 EDP44779.1 - 3.4e-33 114.7 0.2 4.4e-33 114.4 0.2 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EDP44779.1 - 0.006 17.0 0.0 0.0078 16.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) FKBP_C PF00254.28 EDP44780.1 - 1.3e-23 83.1 0.0 1.5e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ING PF12998.7 EDP44781.1 - 3e-10 40.6 0.1 6.4e-10 39.5 0.0 1.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EDP44781.1 - 1.8e-05 24.5 6.8 2.9e-05 23.8 6.8 1.4 1 0 0 1 1 1 1 PHD-finger RP-C PF03428.13 EDP44781.1 - 0.085 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Replication protein C N-terminal domain zf-HC5HC2H PF13771.6 EDP44781.1 - 0.089 13.1 1.0 0.17 12.1 1.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EDP44781.1 - 0.13 11.8 2.6 0.25 10.9 2.6 1.4 1 0 0 1 1 1 0 PHD-finger EF1_GNE PF00736.19 EDP44782.1 - 7.3e-34 115.8 2.7 1.4e-33 115.0 2.0 1.8 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EDP44782.1 - 5.6e-12 45.9 2.9 5.6e-12 45.9 2.9 2.4 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 EDP44782.1 - 0.00041 20.5 0.1 0.00098 19.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EDP44782.1 - 0.017 15.1 0.0 0.048 13.7 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP44782.1 - 0.033 14.4 0.3 0.37 11.1 0.0 2.6 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Stm1_N PF09598.10 EDP44782.1 - 0.096 13.5 2.0 0.13 13.1 0.7 1.8 2 0 0 2 2 2 0 Stm1 GST_C_6 PF17171.4 EDP44782.1 - 0.21 11.4 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosom_S12_S23 PF00164.25 EDP44783.1 - 4.6e-37 126.1 0.2 6.3e-37 125.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5538 PF17692.1 EDP44783.1 - 0.36 10.9 5.5 0.64 10.1 5.5 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5538) PH_4 PF15404.6 EDP44784.1 - 3.4e-21 75.9 0.2 3.2e-17 62.9 0.0 2.6 1 1 1 2 2 2 2 Pleckstrin homology domain PH PF00169.29 EDP44784.1 - 1.5e-05 25.5 0.5 11 6.6 0.0 4.4 4 0 0 4 4 4 3 PH domain Nucleo_LEF-12 PF06256.11 EDP44785.1 - 0.048 13.4 0.4 0.091 12.5 0.1 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus LEF-12 protein AA_permease_2 PF13520.6 EDP44787.1 - 3.3e-60 204.1 43.4 3.8e-60 203.9 43.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF5408 PF17402.2 EDP44787.1 - 0.16 11.9 2.0 5.2 7.0 1.5 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5408) TMEM107 PF14995.6 EDP44787.1 - 2.3 8.7 12.7 0.87 10.0 0.9 3.5 3 0 0 3 3 3 0 Transmembrane protein Peptidase_M48 PF01435.18 EDP44788.1 - 2.8e-31 108.8 2.0 3.2e-30 105.4 1.0 2.5 2 1 0 2 2 2 1 Peptidase family M48 FCH PF00611.23 EDP44788.1 - 0.15 12.4 1.0 1.9 8.8 0.0 2.6 3 0 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Pkinase PF00069.25 EDP44789.1 - 1.6e-27 96.5 0.0 9.9e-27 93.9 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44789.1 - 8.5e-12 44.9 0.0 2.5e-11 43.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44789.1 - 0.00052 19.4 0.0 0.0011 18.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EDP44789.1 - 0.003 17.5 0.1 0.0092 15.9 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EDP44789.1 - 0.0052 15.6 0.0 0.0073 15.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDP44789.1 - 0.0097 15.3 0.4 0.018 14.4 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDP44789.1 - 0.049 12.7 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DEAD PF00270.29 EDP44790.1 - 4.2e-48 163.4 0.0 6.7e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP44790.1 - 7.4e-30 103.6 0.1 3.5e-29 101.4 0.0 2.1 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP44790.1 - 0.0043 17.1 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mgm101p PF06420.12 EDP44791.1 - 2.2e-80 268.2 0.0 2.9e-80 267.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 MFS_1 PF07690.16 EDP44792.1 - 9.9e-23 80.6 33.4 1.1e-17 64.0 15.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP44792.1 - 1.5e-16 60.4 20.8 1.8e-15 56.7 2.9 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter MRP-L20 PF12824.7 EDP44793.1 - 3.1e-35 121.8 4.2 7.9e-35 120.4 4.2 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Pyr_redox_2 PF07992.14 EDP44793.1 - 1.3e-12 47.5 0.0 7.4e-12 45.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP44793.1 - 4.4e-05 23.5 0.1 0.09 12.8 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EDP44793.1 - 0.0033 17.1 0.2 0.024 14.2 0.2 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDP44793.1 - 0.0063 15.8 0.1 0.23 10.7 0.2 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDP44793.1 - 0.024 13.9 0.6 1.4 8.1 0.1 2.7 3 1 0 3 3 3 0 FAD binding domain GIDA PF01134.22 EDP44793.1 - 0.026 13.6 0.7 5.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EDP44793.1 - 0.071 12.1 0.1 0.16 11.0 0.1 1.6 1 1 1 2 2 2 0 Lycopene cyclase protein K_oxygenase PF13434.6 EDP44793.1 - 0.11 11.6 0.2 0.46 9.6 0.0 1.9 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HTH_11 PF08279.12 EDP44793.1 - 0.11 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 HTH domain Copper-fist PF00649.18 EDP44794.1 - 1.8e-13 49.7 1.1 1.8e-13 49.7 1.1 2.7 3 0 0 3 3 3 1 Copper fist DNA binding domain TPR_14 PF13428.6 EDP44795.1 - 1e-15 57.0 24.3 0.00076 20.1 0.1 10.8 5 2 7 12 12 11 4 Tetratricopeptide repeat HAT PF02184.16 EDP44795.1 - 4.1e-15 55.4 63.8 4e-09 36.3 0.8 14.3 16 0 0 16 16 16 5 HAT (Half-A-TPR) repeat Suf PF05843.14 EDP44795.1 - 1.4e-12 48.2 16.4 0.0076 16.3 0.4 7.1 4 3 2 6 6 6 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EDP44795.1 - 1.9e-11 44.3 0.1 0.0045 17.5 0.0 6.4 4 3 2 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EDP44795.1 - 2.1e-07 30.5 1.7 0.66 10.2 0.0 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EDP44795.1 - 4e-05 23.7 2.0 0.09 13.2 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP44795.1 - 0.0001 22.2 0.3 3.4 8.1 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat SNAP PF14938.6 EDP44795.1 - 0.00093 18.7 1.3 0.0045 16.5 0.1 2.5 3 0 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_15 PF13429.6 EDP44795.1 - 0.0012 18.2 16.1 0.32 10.2 0.5 4.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP44795.1 - 0.0092 16.2 8.5 2.9 8.3 0.6 5.0 5 2 0 5 5 5 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EDP44795.1 - 0.017 15.1 16.6 1.1 9.2 1.0 6.6 6 2 1 7 7 7 0 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 EDP44795.1 - 0.019 15.0 3.9 6.4 7.1 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EDP44795.1 - 0.02 14.7 0.0 24 4.9 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ER PF01133.17 EDP44795.1 - 0.072 13.1 0.7 1.6 8.8 0.0 3.5 4 1 1 5 5 5 0 Enhancer of rudimentary TPR_9 PF13371.6 EDP44795.1 - 1.5 9.0 6.5 3.2 8.0 0.1 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat CTP_transf_1 PF01148.20 EDP44796.1 - 0.11 12.3 3.9 0.17 11.6 3.9 1.4 1 1 0 1 1 1 0 Cytidylyltransferase family SF1-HH PF16275.5 EDP44797.1 - 4.9e-37 126.7 2.4 1.1e-36 125.6 2.4 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 EDP44797.1 - 4.3e-12 45.5 13.8 1.3e-06 28.2 1.6 2.4 2 0 0 2 2 2 2 Zinc knuckle DUF1897 PF09005.10 EDP44797.1 - 1e-06 28.1 14.9 0.0024 17.3 5.7 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1897) KH_1 PF00013.29 EDP44797.1 - 2.4e-06 27.3 0.1 4e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EDP44797.1 - 2.9e-05 23.9 12.5 0.00019 21.3 2.9 2.4 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 EDP44797.1 - 0.0017 18.0 0.3 0.0017 18.0 0.3 2.4 2 0 0 2 2 2 1 GAG-polyprotein viral zinc-finger UPF0167 PF03691.14 EDP44797.1 - 0.014 15.2 0.4 0.029 14.2 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) PolC_DP2 PF03833.13 EDP44797.1 - 0.12 10.3 0.4 0.17 9.7 0.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 CCDC-167 PF15188.6 EDP44797.1 - 0.16 12.3 0.7 1.9 8.9 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 zf-CCHC_2 PF13696.6 EDP44797.1 - 1.2 9.0 13.0 4.2 7.3 4.0 2.6 2 0 0 2 2 2 0 Zinc knuckle DUF3602 PF12223.8 EDP44797.1 - 2.3 8.9 6.7 0.36 11.5 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) Mis12 PF05859.12 EDP44798.1 - 2.3e-20 73.0 0.5 3.2e-19 69.3 0.1 2.2 2 0 0 2 2 2 1 Mis12 protein Proteasome PF00227.26 EDP44799.1 - 9.8e-34 116.5 0.0 1.2e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Adap_comp_sub PF00928.21 EDP44800.1 - 5.6e-23 81.6 0.0 9e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family TFIID-31kDa PF02291.15 EDP44801.1 - 2.9e-09 37.0 0.0 3.7e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit RRF PF01765.19 EDP44802.1 - 1.5e-29 103.1 2.4 2.2e-29 102.5 2.4 1.1 1 0 0 1 1 1 1 Ribosome recycling factor Slu7 PF11708.8 EDP44803.1 - 1.4e-90 303.8 22.9 1.6e-90 303.5 22.9 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor Cwf_Cwc_15 PF04889.12 EDP44803.1 - 0.017 14.9 24.7 0.022 14.5 18.0 2.3 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 EDP44803.1 - 0.095 12.6 10.9 0.085 12.7 9.3 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region Pkinase PF00069.25 EDP44804.1 - 5e-71 239.2 0.0 6e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44804.1 - 7.6e-28 97.5 0.0 1.1e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP44804.1 - 0.027 14.4 0.0 0.027 14.4 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP44804.1 - 0.044 12.7 0.0 0.71 8.7 0.0 2.0 2 0 0 2 2 2 0 Haspin like kinase domain Ribosomal_L44 PF00935.19 EDP44805.1 - 3.4e-34 117.2 9.7 4.5e-34 116.8 9.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Cathelicidins PF00666.17 EDP44805.1 - 0.04 14.2 0.5 0.058 13.7 0.5 1.2 1 0 0 1 1 1 0 Cathelicidin LRV_FeS PF05484.11 EDP44805.1 - 0.13 12.3 0.5 0.22 11.5 0.5 1.3 1 0 0 1 1 1 0 LRV protein FeS4 cluster Amino_oxidase PF01593.24 EDP44806.1 - 3.6e-11 43.0 0.0 5.8e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EDP44806.1 - 1.4e-08 34.9 0.2 2.5e-08 34.0 0.2 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EDP44806.1 - 0.002 17.4 0.2 0.063 12.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EDP44806.1 - 0.0038 16.8 0.0 0.0059 16.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EDP44806.1 - 0.014 14.7 0.1 0.028 13.7 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP44806.1 - 0.061 13.3 0.1 0.44 10.5 0.0 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EDP44806.1 - 0.13 11.5 0.1 0.24 10.6 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EDP44806.1 - 0.19 10.4 0.1 0.28 9.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Hexokinase_2 PF03727.16 EDP44807.1 - 2.8e-80 269.2 0.0 4.4e-80 268.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EDP44807.1 - 1.1e-63 214.8 0.0 1.6e-63 214.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase GDC-P PF02347.16 EDP44808.1 - 9.5e-180 598.0 0.0 9.6e-170 565.0 0.0 2.6 3 0 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EDP44808.1 - 0.00038 19.5 0.3 0.00082 18.4 0.3 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDP44808.1 - 0.00076 18.8 0.1 0.0016 17.8 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Pkinase PF00069.25 EDP44809.1 - 8.8e-64 215.4 0.0 1.9e-62 211.0 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44809.1 - 9.4e-27 93.9 0.0 6.4e-20 71.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EDP44809.1 - 3e-07 29.7 0.0 4.7e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP44809.1 - 0.00018 21.5 1.0 0.059 13.3 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP44809.1 - 0.0021 17.4 3.1 0.017 14.4 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.14 EDP44809.1 - 0.0043 16.4 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDP44809.1 - 0.0049 15.7 0.1 0.011 14.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EDP44809.1 - 0.022 13.8 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.11 EDP44809.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase NUFIP1 PF10453.9 EDP44809.1 - 0.18 11.7 0.3 0.47 10.3 0.0 1.8 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Pkinase_C PF00433.24 EDP44809.1 - 0.19 12.4 0.5 0.47 11.2 0.5 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain tRNA_m1G_MT PF01746.21 EDP44810.1 - 6.6e-20 71.6 0.0 8.4e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF411 PF04214.13 EDP44810.1 - 0.033 14.1 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF PCI PF01399.27 EDP44811.1 - 3.1e-05 24.4 0.0 0.00021 21.8 0.0 2.3 1 1 0 1 1 1 1 PCI domain DUF384 PF04064.13 EDP44811.1 - 0.14 12.1 0.2 0.33 10.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF384) Cwf_Cwc_15 PF04889.12 EDP44812.1 - 3.7e-52 177.5 31.5 4.6e-52 177.2 31.5 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Takusan PF04822.13 EDP44812.1 - 0.055 13.4 6.2 0.11 12.4 4.7 2.3 2 0 0 2 2 2 0 Takusan CDC45 PF02724.14 EDP44812.1 - 0.17 10.2 17.0 0.17 10.1 17.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2508 PF10704.9 EDP44812.1 - 0.34 11.1 7.6 0.67 10.2 6.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Nop14 PF04147.12 EDP44812.1 - 0.52 8.5 25.3 0.61 8.2 25.3 1.2 1 0 0 1 1 1 0 Nop14-like family GED PF02212.18 EDP44812.1 - 0.75 10.0 6.8 0.53 10.5 4.7 1.8 2 0 0 2 2 2 0 Dynamin GTPase effector domain CENP-I PF07778.11 EDP44812.1 - 1.1 7.9 6.3 1.5 7.5 6.3 1.2 1 0 0 1 1 1 0 Mis6 NOA36 PF06524.12 EDP44812.1 - 2.5 7.3 17.3 4.4 6.5 17.3 1.5 1 0 0 1 1 1 0 NOA36 protein ATP_bind_1 PF03029.17 EDP44813.1 - 1.5e-82 277.0 0.1 1.7e-82 276.8 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EDP44813.1 - 0.00023 21.7 0.0 0.00062 20.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EDP44813.1 - 0.00048 20.0 0.0 0.0047 16.7 0.0 2.4 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EDP44813.1 - 0.0015 19.0 0.1 0.0063 16.9 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EDP44813.1 - 0.0016 18.2 0.0 0.0023 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDP44813.1 - 0.0018 18.6 0.0 0.0061 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EDP44813.1 - 0.0029 17.7 0.0 0.0039 17.2 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EDP44813.1 - 0.0033 17.2 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EDP44813.1 - 0.0074 16.8 0.0 0.026 15.0 0.0 1.9 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.12 EDP44813.1 - 0.0078 15.6 0.3 0.056 12.8 0.1 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA PF00004.29 EDP44813.1 - 0.0081 16.6 0.0 0.13 12.7 0.0 2.4 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EDP44813.1 - 0.0092 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EDP44813.1 - 0.0093 15.9 0.1 0.77 9.6 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_14 PF13173.6 EDP44813.1 - 0.0098 15.9 0.0 0.025 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EDP44813.1 - 0.012 14.6 0.0 0.022 13.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 EDP44813.1 - 0.017 15.1 0.0 0.046 13.6 0.0 1.7 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 EDP44813.1 - 0.02 13.9 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EDP44813.1 - 0.021 14.2 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Hid1 PF12722.7 EDP44813.1 - 0.021 13.0 0.1 0.029 12.5 0.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMR_HSR1 PF01926.23 EDP44813.1 - 0.03 14.4 0.0 0.14 12.2 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase IstB_IS21 PF01695.17 EDP44813.1 - 0.032 13.9 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 EDP44813.1 - 0.034 13.7 0.4 0.34 10.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EDP44813.1 - 0.05 13.2 0.1 1.3 8.6 0.0 2.3 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EDP44813.1 - 0.05 13.1 0.0 1.1 8.7 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain SRP54 PF00448.22 EDP44813.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 EDP44813.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EDP44813.1 - 0.064 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.7 EDP44813.1 - 0.078 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.6 EDP44813.1 - 0.087 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EDP44813.1 - 0.1 13.0 0.1 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDP44813.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ALAD PF00490.21 EDP44814.1 - 3.6e-65 220.2 0.0 4.1e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase ORF_2_N PF18492.1 EDP44814.1 - 0.18 12.0 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Open reading frame 2 N-terminal domain Dak1 PF02733.17 EDP44814.1 - 0.2 10.5 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Dak1 domain Pkinase PF00069.25 EDP44815.1 - 2.5e-58 197.5 0.0 3.4e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44815.1 - 1.7e-29 102.9 0.2 2.5e-29 102.4 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP44815.1 - 4.8e-07 29.4 0.1 1.8e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EDP44815.1 - 0.0066 16.1 0.2 0.54 9.8 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EDP44815.1 - 0.012 15.5 0.1 0.55 10.1 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EDP44815.1 - 0.016 14.6 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IF4E PF01652.18 EDP44816.1 - 1e-44 152.1 0.1 1.4e-44 151.7 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Shisa PF13908.6 EDP44817.1 - 0.017 15.3 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Exo70 PF03081.15 EDP44818.1 - 4.3e-06 26.0 0.0 4.5e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Exo70 PF03081.15 EDP44819.1 - 2.5e-06 26.8 0.3 1.8e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Y_phosphatase PF00102.27 EDP44820.1 - 7.8e-37 127.1 0.0 1.1e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EDP44820.1 - 0.00048 19.9 0.0 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EDP44820.1 - 0.08 13.1 0.0 0.27 11.3 0.0 1.9 3 0 0 3 3 3 0 Inositol hexakisphosphate Peptidase_M28 PF04389.17 EDP44820.1 - 0.09 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Meth_synt_2 PF01717.18 EDP44823.1 - 1.9e-148 494.0 0.0 1.6e-143 477.9 0.0 2.4 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EDP44823.1 - 2.8e-116 388.4 0.0 9.7e-110 366.9 0.0 3.0 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain SHOCT PF09851.9 EDP44823.1 - 0.00012 21.7 1.3 0.00028 20.5 1.3 1.7 1 0 0 1 1 1 1 Short C-terminal domain URO-D PF01208.17 EDP44823.1 - 0.045 12.9 0.0 4.9 6.2 0.0 2.9 3 0 0 3 3 3 0 Uroporphyrinogen decarboxylase (URO-D) Methyltransf_7 PF03492.15 EDP44824.1 - 0.00027 20.3 2.3 0.38 9.9 0.0 2.9 1 1 1 2 2 2 2 SAM dependent carboxyl methyltransferase FYVE PF01363.21 EDP44825.1 - 3.5e-16 59.1 7.8 7.4e-16 58.0 7.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 EDP44825.1 - 1.4e-10 40.8 1.4 1.4e-10 40.8 1.4 2.0 2 0 0 2 2 2 1 Rabenosyn Rab binding domain Prok-RING_2 PF14445.6 EDP44825.1 - 0.37 11.0 3.9 0.99 9.6 3.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 DPBB_1 PF03330.18 EDP44826.1 - 2.6e-05 24.4 0.1 7.6e-05 22.9 0.1 1.7 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EDP44826.1 - 0.0099 15.7 0.1 0.013 15.3 0.1 1.3 1 1 0 1 1 1 1 Barwin family ETF_QO PF05187.13 EDP44827.1 - 5.7e-43 145.3 0.2 1e-42 144.5 0.2 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EDP44827.1 - 3.9e-07 30.0 2.0 0.00097 18.8 1.5 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EDP44827.1 - 6.1e-07 28.9 2.0 0.00026 20.2 2.1 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EDP44827.1 - 2.5e-06 27.6 0.1 1.2e-05 25.4 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EDP44827.1 - 1.4e-05 24.5 0.0 0.00014 21.2 0.2 2.0 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EDP44827.1 - 0.00011 21.5 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EDP44827.1 - 0.00021 20.1 1.3 0.00032 19.5 1.3 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDP44827.1 - 0.00031 20.1 1.1 0.00049 19.4 1.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDP44827.1 - 0.00037 19.6 0.2 0.00059 19.0 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EDP44827.1 - 0.0018 17.6 0.4 0.0028 17.0 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EDP44827.1 - 0.004 16.5 0.3 0.0064 15.9 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EDP44827.1 - 0.0046 17.0 0.3 0.01 15.8 0.3 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EDP44827.1 - 0.044 13.1 0.3 0.069 12.4 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_7 PF12838.7 EDP44827.1 - 0.044 14.4 2.5 0.1 13.2 2.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Trp_halogenase PF04820.14 EDP44827.1 - 0.049 12.5 0.8 0.12 11.2 0.8 1.6 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 EDP44827.1 - 0.16 12.5 0.5 13 6.4 0.6 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EDP44827.1 - 0.31 10.1 0.7 0.49 9.4 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DNA_RNApol_7kD PF03604.13 EDP44827.1 - 0.42 10.3 2.8 0.85 9.4 2.8 1.5 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Fer4_2 PF12797.7 EDP44827.1 - 0.44 10.8 3.6 0.16 12.1 0.4 1.9 2 0 0 2 2 1 0 4Fe-4S binding domain Fer4_6 PF12837.7 EDP44827.1 - 1.6 8.9 4.7 0.71 10.1 0.9 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain PhetRS_B1 PF18262.1 EDP44828.1 - 4e-31 107.1 0.1 6.4e-31 106.4 0.1 1.3 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EDP44828.1 - 2.2e-10 40.5 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 B3/4 domain G-patch PF01585.23 EDP44830.1 - 4.2e-12 45.8 2.5 1.1e-11 44.5 2.5 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EDP44830.1 - 0.0039 17.2 1.7 0.011 15.8 1.7 1.8 1 0 0 1 1 1 1 G-patch domain polyprenyl_synt PF00348.17 EDP44831.1 - 2.1e-93 312.1 0.0 3e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CN_hydrolase PF00795.22 EDP44832.1 - 2.3e-51 174.7 0.0 3.4e-51 174.1 0.0 1.2 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Peptidase_S24 PF00717.23 EDP44833.1 - 0.00017 21.5 0.1 0.0074 16.2 0.0 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 EDP44833.1 - 0.065 13.0 0.0 15 5.3 0.0 3.1 2 1 1 3 3 3 0 Signal peptidase, peptidase S26 Metallophos PF00149.28 EDP44834.1 - 9.8e-09 36.0 1.4 1.9e-08 35.1 1.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ICL PF00463.21 EDP44835.1 - 7.6e-192 638.5 0.0 8.8e-192 638.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EDP44835.1 - 5.6e-08 32.5 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase RNA_pol_Rpc4 PF05132.14 EDP44836.1 - 7.7e-27 94.6 1.1 7.7e-27 94.6 1.1 3.1 2 2 0 2 2 2 1 RNA polymerase III RPC4 DUF2408 PF10303.9 EDP44837.1 - 5.7e-45 153.2 0.8 2.6e-34 118.7 0.0 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF2408) DUF885 PF05960.11 EDP44837.1 - 0.068 12.8 0.2 0.1 12.2 0.0 1.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF885) DUF3251 PF11622.8 EDP44837.1 - 0.14 11.8 0.8 0.42 10.2 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Spc7 PF08317.11 EDP44837.1 - 0.59 9.0 7.5 0.065 12.1 0.7 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein Laminin_II PF06009.12 EDP44837.1 - 0.63 10.0 6.1 7.2 6.6 1.1 4.0 4 1 1 5 5 5 0 Laminin Domain II DUF1664 PF07889.12 EDP44837.1 - 1.2 9.2 5.7 5.5 7.1 0.4 3.5 4 1 0 5 5 5 0 Protein of unknown function (DUF1664) COG6 PF06419.11 EDP44837.1 - 1.4 7.0 6.2 0.23 9.6 0.3 2.6 4 1 0 5 5 5 0 Conserved oligomeric complex COG6 Fib_alpha PF08702.10 EDP44837.1 - 1.8 8.7 9.7 2.2 8.5 0.3 3.3 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 EDP44837.1 - 4.8 7.7 10.8 0.75 10.3 2.3 3.0 3 1 0 3 3 3 0 Apg6 coiled-coil region Sas10_Utp3 PF04000.15 EDP44837.1 - 5 7.8 6.1 18 6.0 0.3 4.0 3 2 0 3 3 3 0 Sas10/Utp3/C1D family Bax1-I PF01027.20 EDP44838.1 - 5.9e-38 130.8 8.3 8.6e-38 130.2 8.3 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Profilin PF00235.19 EDP44839.1 - 2.9e-46 156.8 0.0 3.3e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 Profilin TIM PF00121.18 EDP44840.1 - 4.9e-94 314.2 0.1 5.6e-94 314.1 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.14 EDP44840.1 - 0.034 13.6 0.1 0.12 11.8 0.0 1.7 1 1 1 2 2 2 0 CutC family DUF3802 PF12290.8 EDP44840.1 - 0.11 13.0 0.2 9.3 6.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3802) RNA_pol_Rpa2_4 PF06883.12 EDP44840.1 - 0.16 12.0 0.1 1.7 8.7 0.1 2.3 2 1 0 2 2 2 0 RNA polymerase I, Rpa2 specific domain Spo12 PF05032.12 EDP44841.1 - 4.4e-11 42.5 1.7 8.2e-11 41.6 1.7 1.5 1 0 0 1 1 1 1 Spo12 family MBD PF01429.19 EDP44841.1 - 0.045 13.5 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyl-CpG binding domain AICARFT_IMPCHas PF01808.18 EDP44842.1 - 1.2e-87 294.2 0.0 1.6e-87 293.7 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EDP44842.1 - 4e-20 71.8 0.0 8e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Ribosomal_S11 PF00411.19 EDP44842.1 - 0.039 14.3 0.2 0.19 12.1 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S11 Mon1 PF03164.14 EDP44843.1 - 1.3e-42 146.4 0.0 1.6e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 TraC_F_IV PF11130.8 EDP44843.1 - 0.044 13.4 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer Methyltransf_10 PF05971.12 EDP44844.1 - 2.6e-21 76.2 0.0 3.4e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase CoA_transf_3 PF02515.17 EDP44844.1 - 0.0077 15.4 0.0 0.01 15.0 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III LIAS_N PF16881.5 EDP44845.1 - 1.9e-15 57.2 0.0 7.1e-15 55.3 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EDP44845.1 - 5.7e-11 43.1 0.0 9e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily DUF551 PF04448.12 EDP44845.1 - 0.12 13.3 0.0 0.22 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF551) ATP_bind_1 PF03029.17 EDP44846.1 - 3.8e-68 229.9 0.5 3e-61 207.3 0.0 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EDP44846.1 - 8.3e-06 25.5 0.0 6.3e-05 22.6 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EDP44846.1 - 3.9e-05 23.3 0.0 0.21 11.2 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EDP44846.1 - 7.6e-05 22.7 0.0 0.049 13.5 0.0 3.0 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 EDP44846.1 - 8.5e-05 22.6 0.0 0.51 10.4 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EDP44846.1 - 0.00049 20.5 0.1 0.0019 18.6 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EDP44846.1 - 0.00049 20.1 0.0 0.0009 19.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 EDP44846.1 - 0.00054 19.6 0.3 0.0065 16.1 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EDP44846.1 - 0.00062 20.0 0.1 0.0015 18.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EDP44846.1 - 0.00066 19.2 0.0 0.0082 15.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EDP44846.1 - 0.002 17.1 0.1 0.013 14.6 0.0 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EDP44846.1 - 0.0031 17.5 0.0 0.24 11.3 0.0 2.3 2 0 0 2 2 2 1 NTPase AAA_25 PF13481.6 EDP44846.1 - 0.0037 16.9 0.2 0.081 12.5 0.2 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDP44846.1 - 0.009 16.3 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP44846.1 - 0.012 16.2 0.0 0.024 15.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EDP44846.1 - 0.019 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EDP44846.1 - 0.02 14.6 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDP44846.1 - 0.021 14.0 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EDP44846.1 - 0.023 15.1 0.0 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 EDP44846.1 - 0.024 14.0 0.1 0.15 11.4 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 EDP44846.1 - 0.031 14.4 1.4 0.071 13.2 0.3 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 EDP44846.1 - 0.034 13.9 0.2 0.14 11.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EDP44846.1 - 0.063 12.7 0.5 1.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 EDP44846.1 - 0.065 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 EDP44846.1 - 0.066 13.3 0.0 0.1 12.7 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain KAP_NTPase PF07693.14 EDP44846.1 - 0.079 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain MipZ PF09140.11 EDP44846.1 - 0.092 12.0 1.2 0.78 9.0 0.0 2.2 2 0 0 2 2 2 0 ATPase MipZ AAA_17 PF13207.6 EDP44846.1 - 0.1 13.0 0.1 0.4 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF463 PF04317.12 EDP44846.1 - 0.11 11.4 0.3 0.82 8.5 0.1 2.3 3 0 0 3 3 3 0 YcjX-like family, DUF463 G-alpha PF00503.20 EDP44846.1 - 0.2 10.8 0.0 14 4.7 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit ADH_N PF08240.12 EDP44847.1 - 3e-24 85.0 2.8 1.1e-23 83.1 2.7 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDP44847.1 - 4e-10 39.8 0.0 7.9e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EDP44847.1 - 0.00016 21.1 0.1 0.00024 20.5 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EDP44847.1 - 0.00085 19.5 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.21 EDP44847.1 - 0.0017 17.7 0.5 0.0029 17.0 0.5 1.3 1 0 0 1 1 1 1 ThiF family AlaDh_PNT_C PF01262.21 EDP44847.1 - 0.0022 17.3 0.4 0.013 14.8 0.1 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 EDP44847.1 - 0.0028 17.3 0.0 0.0049 16.5 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EDP44847.1 - 0.014 15.3 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EDP44847.1 - 0.036 14.1 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 EDP44847.1 - 0.091 12.2 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase DUF202 PF02656.15 EDP44848.1 - 1.4e-18 67.0 1.1 2.2e-18 66.4 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) COX17 PF05051.13 EDP44849.1 - 3.9e-20 71.9 5.7 5.9e-20 71.3 5.7 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 EDP44849.1 - 0.0011 19.2 0.3 0.0013 18.9 0.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Ribosomal_60s PF00428.19 EDP44850.1 - 2e-26 92.4 10.2 2.4e-26 92.2 10.2 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 EDP44850.1 - 0.022 13.2 3.4 0.027 12.9 3.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 EDP44850.1 - 0.041 14.5 3.4 0.06 14.0 3.4 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Trehalase PF01204.18 EDP44851.1 - 1.9e-157 525.2 0.1 2.4e-157 524.9 0.1 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EDP44851.1 - 1.2e-13 50.4 2.8 2e-13 49.8 2.8 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain ThiF PF00899.21 EDP44852.1 - 2.3e-43 148.3 0.0 4.5e-43 147.3 0.0 1.5 1 1 0 1 1 1 1 ThiF family ATG7_N PF16420.5 EDP44852.1 - 3.2e-20 73.0 0.0 5.2e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 EDP44852.1 - 0.00072 19.6 0.0 0.026 14.6 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DUF2318 PF10080.9 EDP44852.1 - 0.019 15.0 0.4 0.044 13.9 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) ApbA PF02558.16 EDP44852.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CDO_I PF05995.12 EDP44852.1 - 0.14 11.5 0.1 0.34 10.2 0.1 1.6 1 0 0 1 1 1 0 Cysteine dioxygenase type I ALS_ss_C PF10369.9 EDP44853.1 - 1.1e-17 64.0 0.1 1.7e-15 56.9 0.0 2.7 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 EDP44853.1 - 1.3e-11 44.0 0.1 2.2e-11 43.3 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EDP44853.1 - 2.2e-06 27.4 0.0 4.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EDP44853.1 - 0.13 12.8 0.0 0.37 11.4 0.0 1.8 1 0 0 1 1 1 0 ACT domain ACT_7 PF13840.6 EDP44853.1 - 0.14 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 ACT domain ACT_6 PF13740.6 EDP44853.1 - 0.23 11.5 1.4 0.38 10.8 0.1 2.2 3 1 0 3 3 3 0 ACT domain ERO1 PF04137.15 EDP44854.1 - 2.2e-128 428.4 0.0 2.7e-128 428.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DASH_Dad4 PF08650.10 EDP44857.1 - 1.3e-27 95.5 6.7 1.5e-27 95.3 6.7 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DASH_Dad1 PF08649.10 EDP44857.1 - 0.0033 17.6 1.5 0.0054 16.9 1.5 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad1 ArgoL1 PF08699.10 EDP44857.1 - 0.068 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Argonaute linker 1 domain Ribosomal_S21 PF01165.20 EDP44858.1 - 1.6e-09 37.3 9.4 2.8e-09 36.5 9.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S21 Rot1 PF10681.9 EDP44859.1 - 2.2e-42 145.0 1.3 2.7e-42 144.7 1.3 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Lipocalin_4 PF13648.6 EDP44859.1 - 0.07 14.1 3.1 0.16 13.0 3.1 1.7 1 1 0 1 1 1 0 Lipocalin-like domain NAT PF04768.13 EDP44860.1 - 5.5e-33 114.0 0.0 6.8e-22 77.9 0.0 2.2 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase MBOAT PF03062.19 EDP44861.1 - 1.7e-08 34.2 0.8 3.8e-08 33.1 0.6 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Clat_adaptor_s PF01217.20 EDP44862.1 - 5.7e-55 185.2 1.4 6.8e-55 184.9 1.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Pcc1 PF09341.10 EDP44863.1 - 1.4e-20 73.2 0.3 1.7e-20 72.9 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 PIF1 PF05970.14 EDP44864.1 - 1.2e-60 205.6 0.1 7.2e-48 163.6 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EDP44864.1 - 5.4e-24 85.0 0.0 1.1e-23 84.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDP44864.1 - 3e-09 37.4 0.0 6.1e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EDP44864.1 - 8.6e-06 26.1 0.0 5.6e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EDP44864.1 - 2.9e-05 23.9 0.0 0.034 13.9 0.0 2.6 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Herpes_Helicase PF02689.14 EDP44864.1 - 0.00014 20.0 0.2 0.014 13.4 0.0 2.3 2 0 0 2 2 2 1 Helicase AAA_7 PF12775.7 EDP44864.1 - 0.00048 19.7 0.0 0.0017 17.9 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 EDP44864.1 - 0.0014 18.6 0.1 0.019 15.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP44864.1 - 0.0022 18.4 0.6 0.0071 16.8 0.0 2.2 2 2 0 2 2 2 1 AAA ATPase domain TsaE PF02367.17 EDP44864.1 - 0.003 17.6 0.0 0.006 16.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 EDP44864.1 - 0.008 16.1 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase UvrD_C_2 PF13538.6 EDP44864.1 - 0.0081 16.0 0.7 0.037 13.8 0.7 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 EDP44864.1 - 0.01 15.3 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.29 EDP44864.1 - 0.011 16.1 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDP44864.1 - 0.013 15.4 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EDP44864.1 - 0.02 14.9 0.0 0.12 12.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EDP44864.1 - 0.043 14.3 0.1 0.13 12.8 0.1 1.8 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 EDP44864.1 - 0.047 12.8 0.0 0.088 11.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF5605 PF18310.1 EDP44864.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) Zeta_toxin PF06414.12 EDP44864.1 - 0.054 12.8 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ATPase_2 PF01637.18 EDP44864.1 - 0.064 13.2 0.1 0.54 10.1 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea SH3_13 PF18335.1 EDP44864.1 - 0.075 12.9 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain NB-ARC PF00931.22 EDP44864.1 - 0.098 11.8 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF2075 PF09848.9 EDP44864.1 - 0.12 11.6 0.1 0.29 10.3 0.1 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EDP44864.1 - 0.12 12.3 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 EDP44864.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EDP44864.1 - 0.16 12.4 0.2 0.5 10.8 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.26 EDP44864.1 - 0.16 11.7 0.0 0.51 10.0 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain IF-2B PF01008.17 EDP44865.1 - 1.4e-52 178.7 0.0 4.1e-52 177.2 0.0 1.7 1 1 0 1 1 1 1 Initiation factor 2 subunit family DUF2013 PF09431.10 EDP44866.1 - 2.1e-37 128.4 0.4 3.6e-37 127.6 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) ORC4_C PF14629.6 EDP44867.1 - 6.3e-28 97.6 0.0 1.4e-27 96.5 0.0 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EDP44867.1 - 8e-17 62.1 6.2 1.5e-16 61.2 3.6 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDP44867.1 - 2.9e-06 27.6 0.1 0.0011 19.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 EDP44867.1 - 1.6e-05 25.3 0.0 0.046 14.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EDP44867.1 - 1.8e-05 24.7 0.7 0.0024 17.8 0.1 3.0 2 1 0 2 2 2 1 NACHT domain ABC_tran PF00005.27 EDP44867.1 - 0.013 16.0 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter ORC3_N PF07034.11 EDP44867.1 - 0.02 14.0 0.0 0.038 13.1 0.0 1.5 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus DUF815 PF05673.13 EDP44867.1 - 0.024 13.8 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CLASP_N PF12348.8 EDP44867.1 - 0.025 14.1 0.1 0.7 9.4 0.0 2.2 2 0 0 2 2 2 0 CLASP N terminal AAA_7 PF12775.7 EDP44867.1 - 0.031 13.8 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EDP44867.1 - 0.038 14.4 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EDP44867.1 - 0.04 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EDP44867.1 - 0.047 13.6 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PAXNEB PF05625.11 EDP44868.1 - 4.2e-34 118.3 0.0 6.6e-33 114.4 0.0 2.6 1 1 0 1 1 1 1 PAXNEB protein Pex14_N PF04695.13 EDP44868.1 - 5.3 7.7 12.0 12 6.5 5.8 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA PF00004.29 EDP44869.1 - 6.4e-44 149.6 0.0 1.3e-43 148.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP44869.1 - 2.6e-10 39.9 0.0 5.6e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EDP44869.1 - 4.7e-08 32.9 0.6 1.3e-07 31.5 0.4 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EDP44869.1 - 1.2e-07 32.0 0.0 2.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDP44869.1 - 2.6e-06 27.5 0.0 9e-06 25.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP44869.1 - 6.2e-06 26.7 0.1 8.7e-05 23.0 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDP44869.1 - 2.9e-05 24.3 0.8 0.007 16.7 0.2 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EDP44869.1 - 6.4e-05 22.8 0.0 0.00016 21.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EDP44869.1 - 0.001 18.3 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EDP44869.1 - 0.0014 19.1 0.1 0.012 16.2 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 EDP44869.1 - 0.0017 18.5 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EDP44869.1 - 0.0018 17.8 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_3 PF07726.11 EDP44869.1 - 0.0024 17.7 0.0 0.011 15.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EDP44869.1 - 0.0028 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDP44869.1 - 0.0097 15.3 0.1 0.02 14.3 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDP44869.1 - 0.012 15.8 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EDP44869.1 - 0.012 15.3 0.0 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDP44869.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EDP44869.1 - 0.02 14.2 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EDP44869.1 - 0.024 14.4 0.1 0.11 12.2 0.0 2.1 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 EDP44869.1 - 0.026 14.3 0.1 0.43 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EDP44869.1 - 0.028 13.6 0.0 0.059 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EDP44869.1 - 0.029 13.9 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2072 PF09845.9 EDP44869.1 - 0.037 14.3 0.1 0.072 13.4 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA_14 PF13173.6 EDP44869.1 - 0.04 13.9 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EDP44869.1 - 0.045 14.2 0.0 0.085 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EDP44869.1 - 0.057 13.0 0.0 0.18 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EDP44869.1 - 0.062 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 EDP44869.1 - 0.1 13.0 0.0 0.37 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EDP44869.1 - 0.11 12.2 0.0 0.7 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EDP44869.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EDP44869.1 - 0.15 12.0 0.0 0.7 9.8 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Dus PF01207.17 EDP44870.1 - 2.3e-72 243.7 0.0 7.1e-72 242.1 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) NMO PF03060.15 EDP44870.1 - 0.052 12.9 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DHHC PF01529.20 EDP44871.1 - 2.8e-34 118.1 5.5 4.1e-34 117.6 5.5 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase zinc_ribbon_2 PF13240.6 EDP44871.1 - 0.13 12.0 4.0 0.24 11.2 4.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EDP44871.1 - 0.34 11.0 9.5 0.65 10.1 9.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon Nodulin-like PF06813.13 EDP44872.1 - 9.7e-22 77.6 6.9 1.3e-21 77.2 6.9 1.1 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 EDP44872.1 - 7e-17 61.4 3.2 1.1e-16 60.7 3.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4516 PF14990.6 EDP44872.1 - 0.028 14.2 0.0 0.028 14.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4516) UreF PF01730.16 EDP44873.1 - 1.2e-14 55.0 4.2 1.4e-14 54.8 2.1 2.1 1 1 1 2 2 2 1 UreF zf-ZPR1 PF03367.13 EDP44874.1 - 1.1e-108 360.2 0.0 5.6e-54 182.3 0.1 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EDP44874.1 - 0.0022 18.0 3.2 0.55 10.3 0.5 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EDP44874.1 - 0.051 13.6 7.5 0.47 10.5 0.2 3.1 2 1 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EDP44874.1 - 0.1 12.6 1.3 4.9 7.2 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbons Zn-ribbon_8 PF09723.10 EDP44874.1 - 2.6 8.2 7.4 8.6 6.6 0.1 3.6 3 1 0 3 3 3 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EDP44874.1 - 3.5 7.2 15.8 2.5 7.6 0.3 4.3 5 0 0 5 5 5 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EDP44874.1 - 4.9 7.2 7.7 5 7.1 0.2 3.1 4 0 0 4 4 4 0 Putative transposase DNA-binding domain UPF0160 PF03690.13 EDP44875.1 - 1.6e-127 425.6 0.0 1.8e-127 425.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF4841 PF16129.5 EDP44875.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4841) GMC_oxred_N PF00732.19 EDP44876.1 - 7.1e-58 196.3 0.0 1.1e-57 195.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDP44876.1 - 5.4e-34 117.8 0.0 1.4e-33 116.4 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EDP44876.1 - 5.3e-05 22.4 0.1 9.6e-05 21.6 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EDP44876.1 - 0.00039 19.7 0.1 0.00073 18.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EDP44876.1 - 0.00047 20.3 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDP44876.1 - 0.0011 18.6 0.1 0.0019 17.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP44876.1 - 0.0014 17.9 0.2 0.012 14.9 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EDP44876.1 - 0.0015 17.7 0.3 0.0027 16.8 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EDP44876.1 - 0.0054 15.5 0.6 0.025 13.3 0.1 1.9 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDP44876.1 - 0.073 12.3 0.7 1 8.5 0.4 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HORMA PF02301.18 EDP44876.1 - 0.16 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 HORMA domain TrkA_N PF02254.18 EDP44876.1 - 0.25 11.6 0.9 0.7 10.2 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain PRKCSH PF07915.13 EDP44878.1 - 0.042 14.8 0.4 0.24 12.4 0.0 2.4 2 1 0 2 2 2 0 Glucosidase II beta subunit-like protein MHC_I_3 PF16497.5 EDP44878.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 MHC-I family domain RNase_H2_suC PF08615.11 EDP44879.1 - 2.8e-10 40.5 0.0 4.5e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Evr1_Alr PF04777.13 EDP44881.1 - 9.6e-30 103.0 1.2 7e-29 100.2 1.3 2.0 2 0 0 2 2 2 1 Erv1 / Alr family Phage_lysozyme PF00959.19 EDP44881.1 - 0.095 13.2 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Phage lysozyme Indigoidine_A PF04227.12 EDP44882.1 - 2.8e-113 378.1 0.5 4.6e-113 377.4 0.1 1.6 2 0 0 2 2 2 1 Indigoidine synthase A like protein PfkB PF00294.24 EDP44882.1 - 2.6e-18 66.4 0.2 6.7e-18 65.0 0.2 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Abhydrolase_1 PF00561.20 EDP44883.1 - 4.5e-21 75.7 0.1 2.2e-16 60.3 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EDP44883.1 - 1.9e-17 64.7 0.0 3e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EDP44883.1 - 1.6e-14 53.8 0.0 4.1e-14 52.4 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EDP44883.1 - 3.1e-05 23.7 0.0 5.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 EDP44883.1 - 0.00073 19.1 0.0 1 8.9 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Thioesterase PF00975.20 EDP44883.1 - 0.00099 19.3 0.0 0.0015 18.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 EDP44883.1 - 0.014 14.9 0.1 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EDP44883.1 - 0.023 14.6 0.1 0.26 11.1 0.1 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EDP44883.1 - 0.028 14.2 0.0 0.3 10.9 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 EDP44883.1 - 0.086 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Methyltransf_PK PF05891.12 EDP44884.1 - 1e-45 156.0 0.0 2.4e-20 73.0 0.0 3.4 2 2 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EDP44884.1 - 1.5e-07 32.0 0.0 0.029 15.1 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EDP44884.1 - 3.7e-06 27.5 0.0 0.085 13.5 0.0 2.8 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 EDP44884.1 - 0.038 14.7 0.0 0.73 10.6 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain CitG PF01874.16 EDP44884.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase Na_H_Exchanger PF00999.21 EDP44885.1 - 8.1e-56 189.4 15.6 9.7e-56 189.2 15.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EDP44885.1 - 2.6e-06 27.4 0.3 0.0002 21.4 0.0 2.8 2 0 0 2 2 2 1 YrhC-like protein 7tm_3 PF00003.22 EDP44885.1 - 0.36 10.5 14.7 0.05 13.3 3.0 3.1 2 1 0 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR Anoctamin PF04547.12 EDP44886.1 - 1.6e-08 33.9 0.4 2.2e-08 33.4 0.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel bZIP_2 PF07716.15 EDP44886.1 - 0.068 13.3 1.5 0.12 12.5 1.5 1.3 1 0 0 1 1 1 0 Basic region leucine zipper Anoctamin PF04547.12 EDP44887.1 - 2.2e-71 241.0 5.1 2.8e-71 240.7 5.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel SieB PF14163.6 EDP44887.1 - 0.036 13.6 2.0 0.058 12.9 0.2 2.2 2 1 0 2 2 2 0 Super-infection exclusion protein B UBX PF00789.20 EDP44888.1 - 5.9e-17 61.6 0.1 1.7e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 UBX domain Abhydrolase_1 PF00561.20 EDP44889.1 - 0.0079 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDP44889.1 - 0.029 13.6 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EDP44889.1 - 0.074 12.0 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 EDP44889.1 - 0.074 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 EDP44889.1 - 0.078 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Putative esterase Abhydrolase_6 PF12697.7 EDP44889.1 - 0.1 13.2 0.0 0.28 11.7 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Chlorophyllase PF07224.11 EDP44889.1 - 0.19 10.7 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Memo PF01875.17 EDP44891.1 - 3.7e-39 134.5 0.0 4.2e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein ResIII PF04851.15 EDP44892.1 - 6.3e-25 88.1 0.1 1.8e-24 86.7 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EDP44892.1 - 1.1e-17 64.3 0.0 2.3e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP44892.1 - 5e-12 46.2 0.0 4.4e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 EDP44892.1 - 4.9e-07 29.7 0.0 7.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_11 PF13086.6 EDP44892.1 - 1.6e-05 24.9 0.0 0.017 15.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain DUF2075 PF09848.9 EDP44892.1 - 0.00014 21.3 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EDP44892.1 - 0.0004 20.2 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EDP44892.1 - 0.0014 19.0 0.3 0.0049 17.2 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EDP44892.1 - 0.0065 16.7 0.0 0.023 15.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EDP44892.1 - 0.0092 15.5 0.2 1.6 8.1 0.3 2.3 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain cobW PF02492.19 EDP44892.1 - 0.018 14.7 0.0 0.24 11.0 0.0 2.5 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EDP44892.1 - 0.033 13.9 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EDP44892.1 - 0.077 13.1 0.0 0.41 10.7 0.0 2.1 3 0 0 3 3 3 0 Helicase HerA, central domain Helicase_RecD PF05127.14 EDP44892.1 - 0.12 12.2 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 Helicase DUF1992 PF09350.10 EDP44894.1 - 2.5e-18 66.0 1.9 1.1e-16 60.7 0.3 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF1992) Cyt-b5 PF00173.28 EDP44895.1 - 5.4e-13 48.9 0.0 1.2e-12 47.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cys_Met_Meta_PP PF01053.20 EDP44896.1 - 1.3e-26 93.1 0.0 1.5e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDP44896.1 - 3.5e-05 23.1 0.0 4.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EDP44896.1 - 0.0042 16.1 0.0 0.0055 15.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EDP44897.1 - 3.2e-13 49.0 1.5 3e-12 45.8 1.5 2.3 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme STALD PF18185.1 EDP44899.1 - 0.085 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family Arabino_trans_N PF17689.1 EDP44899.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Arabinosyltransferase concanavalin like domain PPTA PF01239.22 EDP44900.1 - 2.7e-16 58.7 3.3 2.7e-09 36.5 0.2 2.2 2 0 0 2 2 2 2 Protein prenyltransferase alpha subunit repeat ApoO PF09769.9 EDP44901.1 - 1.1e-15 57.7 0.2 3.7e-15 56.0 0.1 1.8 2 0 0 2 2 2 1 Apolipoprotein O DUF3384 PF11864.8 EDP44902.1 - 0.0056 15.6 0.1 0.0064 15.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) RPN6_N PF18055.1 EDP44902.1 - 0.011 16.1 0.0 0.34 11.3 0.0 2.7 2 1 1 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_7 PF13176.6 EDP44902.1 - 0.2 11.8 2.1 19 5.6 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TatD_DNase PF01026.21 EDP44904.1 - 4.6e-39 134.3 0.0 6.2e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase DUF3591 PF12157.8 EDP44905.1 - 3.2e-155 517.1 2.0 5.6e-127 424.1 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 EDP44905.1 - 6.5e-06 25.9 2.4 1.4e-05 24.9 2.4 1.5 1 0 0 1 1 1 1 Zinc knuckle ApbA_C PF08546.11 EDP44907.1 - 1.6e-38 131.7 0.0 2.4e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDP44907.1 - 1.6e-22 79.7 0.0 1.1e-17 64.1 0.0 2.3 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA SMC_N PF02463.19 EDP44908.1 - 2e-25 89.5 0.0 1.4e-12 47.6 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EDP44908.1 - 4.1e-13 50.3 23.0 4.1e-13 50.3 23.0 4.7 2 2 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EDP44908.1 - 6.1e-12 45.9 1.4 7.8e-12 45.6 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EDP44908.1 - 6.1e-06 26.3 3.3 0.0013 18.6 1.9 2.8 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP44908.1 - 7.9e-05 22.3 0.2 0.0002 21.0 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_hinge PF06470.13 EDP44908.1 - 0.004 17.5 0.1 0.021 15.1 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain ABC_tran PF00005.27 EDP44908.1 - 0.046 14.2 0.1 0.046 14.2 0.1 5.4 3 2 0 4 4 4 0 ABC transporter Peptidase_S10 PF00450.22 EDP44908.1 - 0.28 10.5 1.0 17 4.7 3.4 2.4 2 0 0 2 2 2 0 Serine carboxypeptidase Abhydrolase_1 PF00561.20 EDP44909.1 - 6.9e-12 45.5 0.0 8.4e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EDP44909.1 - 1.4e-11 44.1 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EDP44909.1 - 4.9e-08 32.9 0.0 6.8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EDP44909.1 - 1.9e-07 32.0 0.5 3.1e-07 31.2 0.5 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 EDP44909.1 - 0.0013 17.5 0.0 0.06 12.0 0.0 2.0 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 EDP44909.1 - 0.0021 17.7 0.0 0.0056 16.3 0.0 1.6 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 EDP44909.1 - 0.0026 17.6 0.3 0.019 14.9 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EDP44909.1 - 0.0036 16.8 0.1 0.0062 16.1 0.1 1.3 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region BAAT_C PF08840.11 EDP44909.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal 6PF2K PF01591.18 EDP44910.1 - 1.1e-55 188.3 0.0 1.6e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EDP44910.1 - 6.8e-18 65.1 0.1 2.8e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EDP44910.1 - 2.7e-09 37.3 0.0 8e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDP44910.1 - 0.0027 17.2 0.0 0.0051 16.3 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.12 EDP44910.1 - 0.013 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 EDP44910.1 - 0.06 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase tRNA_lig_kinase PF08303.11 EDP44910.1 - 0.08 13.0 0.1 0.28 11.3 0.0 1.8 1 1 1 2 2 2 0 tRNA ligase kinase domain AAA PF00004.29 EDP44910.1 - 0.19 12.2 0.0 0.41 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FRG1 PF06229.12 EDP44911.1 - 3.1e-17 62.9 0.0 9.6e-17 61.3 0.0 1.8 1 1 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 EDP44911.1 - 0.025 14.8 0.0 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 Fascin domain DUF4504 PF14953.6 EDP44912.1 - 8e-06 25.4 0.0 1.7e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4504) OTCace_N PF02729.21 EDP44913.1 - 6.8e-44 149.5 0.2 1e-43 148.9 0.2 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EDP44913.1 - 1.4e-18 67.4 0.0 7.8e-13 48.8 0.0 2.3 1 1 1 2 2 2 2 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GSHPx PF00255.19 EDP44914.1 - 6.9e-36 122.1 0.3 5e-28 96.8 0.0 2.1 2 0 0 2 2 2 2 Glutathione peroxidase AhpC-TSA PF00578.21 EDP44914.1 - 0.0067 16.3 0.0 0.014 15.3 0.0 1.4 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EDP44914.1 - 0.17 11.6 0.0 0.19 11.4 0.0 1.3 1 1 0 1 1 1 0 Redoxin DUF1115 PF06544.12 EDP44915.1 - 8.7e-06 25.9 0.0 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) ydhR PF08803.11 EDP44915.1 - 0.067 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR NDK PF00334.19 EDP44916.1 - 3.6e-55 185.7 0.0 4.1e-55 185.5 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 EDP44916.1 - 0.021 15.3 0.0 0.039 14.5 0.0 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ ABC1 PF03109.16 EDP44917.1 - 2.3e-20 73.0 0.0 6.8e-12 45.6 0.0 3.0 3 0 0 3 3 3 2 ABC1 family Sgf11 PF08209.11 EDP44918.1 - 1.4e-14 53.3 0.6 2.5e-14 52.5 0.6 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-CpG_bind_C PF12269.8 EDP44918.1 - 0.0035 17.2 0.1 0.0053 16.6 0.1 1.2 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain ATP11 PF06644.11 EDP44918.1 - 0.99 9.1 3.5 1.4 8.7 3.5 1.2 1 0 0 1 1 1 0 ATP11 protein ABC_membrane PF00664.23 EDP44920.1 - 2.3e-56 191.5 28.5 2.1e-31 109.6 9.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDP44920.1 - 3.8e-53 179.7 0.0 5e-30 104.8 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDP44920.1 - 8.9e-08 31.8 0.0 0.0012 18.4 0.0 3.4 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP44920.1 - 2.6e-05 23.9 1.2 0.093 12.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EDP44920.1 - 0.00018 21.9 0.0 0.27 11.6 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EDP44920.1 - 0.00058 19.9 0.9 0.13 12.3 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EDP44920.1 - 0.0014 18.4 0.3 1.7 8.3 0.2 2.7 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EDP44920.1 - 0.0015 18.4 2.6 2.1 8.1 0.1 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EDP44920.1 - 0.0017 18.3 0.2 1.8 8.4 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EDP44920.1 - 0.0077 16.8 7.8 0.79 10.2 0.0 3.4 4 0 0 4 4 3 2 AAA domain AAA_25 PF13481.6 EDP44920.1 - 0.011 15.3 0.1 0.34 10.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EDP44920.1 - 0.065 13.5 1.3 9.4 6.5 0.2 3.1 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 EDP44920.1 - 0.079 13.0 4.1 0.13 12.3 0.4 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain cobW PF02492.19 EDP44920.1 - 0.098 12.2 0.5 14 5.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 EDP44920.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.1 5 0 0 5 5 4 0 AAA domain AAA_10 PF12846.7 EDP44920.1 - 0.14 11.1 0.0 8.4 5.2 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain SbcCD_C PF13558.6 EDP44920.1 - 0.14 12.4 0.1 9.2 6.6 0.0 3.5 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit TrwB_AAD_bind PF10412.9 EDP44920.1 - 0.15 10.9 0.2 1.8 7.4 0.4 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 EDP44920.1 - 0.18 11.3 0.2 15 5.0 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region PfkB PF00294.24 EDP44921.1 - 1.6e-66 224.7 1.3 1.9e-66 224.4 1.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EDP44921.1 - 1.5e-06 27.8 0.0 3.5e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase PCI PF01399.27 EDP44922.1 - 3.1e-17 63.0 0.0 1.7e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EDP44922.1 - 8.6e-12 45.0 1.0 8.6e-12 45.0 1.0 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN5 C-terminal domain Paf67 PF10255.9 EDP44922.1 - 0.037 13.0 0.5 0.2 10.6 0.0 2.3 3 0 0 3 3 3 0 RNA polymerase I-associated factor PAF67 Sec5 PF15469.6 EDP44923.1 - 7.5e-52 175.9 0.0 1.4e-51 175.0 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 V_ATPase_I_N PF18670.1 EDP44923.1 - 0.023 15.1 0.0 0.059 13.8 0.0 1.7 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain Vps51 PF08700.11 EDP44923.1 - 0.039 14.0 0.0 0.13 12.3 0.0 2.0 1 0 0 1 1 1 0 Vps51/Vps67 Flu_C_NS2 PF03555.14 EDP44923.1 - 0.12 12.6 1.8 4 7.7 0.0 3.0 3 0 0 3 3 3 0 Influenza C non-structural protein (NS2) SURF1 PF02104.15 EDP44924.1 - 3.5e-42 144.6 0.0 4.5e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Complex1_51K PF01512.17 EDP44925.1 - 1.7e-47 161.1 0.0 2.4e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EDP44925.1 - 3e-27 94.5 0.1 5.2e-27 93.7 0.1 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EDP44925.1 - 4.4e-08 32.9 0.0 1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 SLBB domain FA_desaturase PF00487.24 EDP44926.1 - 6.7e-23 81.8 16.3 2.7e-22 79.8 14.2 2.1 1 1 1 2 2 2 2 Fatty acid desaturase Lipid_DES PF08557.10 EDP44926.1 - 1.4e-17 62.9 0.3 2.7e-17 61.9 0.3 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) GSH_synth_ATP PF03917.17 EDP44927.1 - 5.9e-124 413.6 0.0 6.9e-124 413.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EDP44927.1 - 4.5e-35 120.2 0.0 8.2e-35 119.4 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase TIP49 PF06068.13 EDP44929.1 - 1.1e-154 514.9 0.4 1.5e-154 514.4 0.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EDP44929.1 - 1.5e-22 79.5 0.8 1.4e-21 76.4 0.6 2.4 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EDP44929.1 - 2.4e-10 41.0 0.3 1.1e-07 32.4 0.1 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDP44929.1 - 2.5e-07 30.6 0.1 0.00034 20.4 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDP44929.1 - 7.7e-06 26.0 0.5 0.0067 16.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EDP44929.1 - 9.8e-06 25.1 2.2 0.00022 20.7 0.7 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 EDP44929.1 - 2e-05 24.1 0.6 3.6e-05 23.2 0.6 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EDP44929.1 - 0.00016 22.0 0.0 0.58 10.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EDP44929.1 - 0.00077 19.2 0.1 0.65 9.7 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 EDP44929.1 - 0.00099 19.5 4.9 0.0018 18.6 1.3 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EDP44929.1 - 0.0019 18.6 0.0 0.0079 16.6 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.6 EDP44929.1 - 0.0024 18.3 0.1 0.01 16.2 0.1 2.1 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EDP44929.1 - 0.0045 17.1 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EDP44929.1 - 0.011 15.3 0.1 0.037 13.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EDP44929.1 - 0.011 15.5 0.4 0.022 14.5 0.4 1.6 1 1 0 1 1 1 0 AAA domain Prot_ATP_ID_OB PF16450.5 EDP44929.1 - 0.02 14.8 0.4 0.062 13.3 0.1 2.0 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain AAA_30 PF13604.6 EDP44929.1 - 0.026 14.3 0.3 0.46 10.2 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EDP44929.1 - 0.026 14.1 1.6 0.052 13.1 0.0 2.2 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EDP44929.1 - 0.066 13.5 0.0 0.19 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EDP44929.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EDP44929.1 - 0.072 12.8 0.3 0.22 11.3 0.2 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EDP44929.1 - 0.083 12.2 0.2 0.19 11.0 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 EDP44929.1 - 0.14 12.1 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Josephin PF02099.17 EDP44930.1 - 2.1e-40 138.5 0.4 2.1e-40 138.5 0.4 1.8 2 0 0 2 2 2 1 Josephin UIM PF02809.20 EDP44930.1 - 1.4 9.0 15.3 0.11 12.4 2.3 3.4 3 0 0 3 3 3 0 Ubiquitin interaction motif AA_permease_2 PF13520.6 EDP44932.1 - 4.7e-36 124.5 23.3 6.4e-36 124.1 23.3 1.2 1 0 0 1 1 1 1 Amino acid permease EAV_GS PF01309.18 EDP44932.1 - 0.32 10.6 5.2 0.26 10.9 0.1 2.6 3 0 0 3 3 3 0 Equine arteritis virus small envelope glycoprotein C2 PF00168.30 EDP44933.1 - 1.6e-23 83.0 0.0 6.4e-15 55.3 0.0 3.5 3 0 0 3 3 3 2 C2 domain MMM1 PF10296.9 EDP44933.1 - 0.035 13.2 0.0 0.035 13.2 0.0 1.8 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 Phage_holin_3_6 PF07332.11 EDP44933.1 - 0.22 11.6 3.2 0.36 10.9 3.2 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III ANAPC4_WD40 PF12894.7 EDP44934.1 - 1.2e-05 25.6 0.0 0.069 13.5 0.0 3.9 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 EDP44934.1 - 0.031 13.0 0.0 0.049 12.3 0.0 1.3 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Frtz PF11768.8 EDP44934.1 - 0.29 9.4 0.0 3.4 5.9 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Lgl_C PF08596.10 EDP44935.1 - 1.1e-07 30.9 0.0 1.5e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal Synaptobrevin PF00957.21 EDP44935.1 - 0.066 13.0 0.7 0.15 11.9 0.7 1.5 1 0 0 1 1 1 0 Synaptobrevin LCCL PF03815.19 EDP44936.1 - 2.3e-18 66.1 0.1 4.1e-18 65.3 0.1 1.4 1 0 0 1 1 1 1 LCCL domain DUF1308 PF07000.11 EDP44936.1 - 4.5e-10 39.7 0.0 7.4e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) CAAD PF14159.6 EDP44936.1 - 0.76 9.6 5.9 0.19 11.6 2.1 1.9 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF2975 PF11188.8 EDP44936.1 - 4.9 7.1 8.5 28 4.6 3.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) AMP-binding PF00501.28 EDP44937.1 - 3.4e-34 118.2 0.2 1.3e-33 116.2 0.0 1.8 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EDP44937.1 - 5.6e-09 36.8 0.3 1.9e-08 35.2 0.1 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ank_5 PF13857.6 EDP44938.1 - 2.5e-07 30.8 0.0 0.045 14.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP44938.1 - 7.3e-07 29.0 0.2 0.25 12.0 0.0 4.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.7 EDP44938.1 - 1.9e-06 28.3 0.0 3.7e-05 24.2 0.0 2.4 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EDP44938.1 - 0.00067 20.2 0.2 0.0034 17.9 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EDP44938.1 - 0.00071 19.9 3.2 0.81 10.2 0.0 3.7 2 1 0 2 2 2 2 Ankyrin repeat FUSC_2 PF13515.6 EDP44939.1 - 1.1e-14 54.6 6.9 2.7e-14 53.4 6.9 1.6 1 0 0 1 1 1 1 Fusaric acid resistance protein-like FUSC PF04632.12 EDP44939.1 - 7.1e-10 38.1 4.8 7.1e-10 38.1 4.8 1.5 2 0 0 2 2 2 1 Fusaric acid resistance protein family ArAE_1 PF06081.11 EDP44939.1 - 3e-05 24.2 2.1 0.00011 22.4 2.1 2.0 1 0 0 1 1 1 1 Aromatic acid exporter family member 1 ALMT PF11744.8 EDP44939.1 - 0.0011 17.9 3.8 0.0011 17.9 3.8 2.0 2 0 0 2 2 2 1 Aluminium activated malate transporter DUF1769 PF08588.10 EDP44940.1 - 9.7e-25 86.5 0.2 2.2e-24 85.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) NPR1_like_C PF12313.8 EDP44940.1 - 0.078 12.5 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal FNIP PF05725.12 EDP44940.1 - 0.1 12.7 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 FNIP Repeat Cellulase PF00150.18 EDP44941.1 - 3.6e-18 66.0 0.8 5.1e-18 65.5 0.8 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RED_N PF07808.13 EDP44941.1 - 0.061 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region GRASP55_65 PF04495.14 EDP44942.1 - 7.4e-61 204.5 0.0 9.4e-54 181.5 0.0 2.1 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EDP44942.1 - 2.6e-06 27.2 0.0 0.00019 21.2 0.0 2.6 2 1 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EDP44942.1 - 0.0003 21.1 0.0 0.095 13.0 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 EDP44942.1 - 0.16 12.3 0.0 11 6.4 0.0 2.4 2 0 0 2 2 2 0 PDZ domain GMC_oxred_N PF00732.19 EDP44943.1 - 3.5e-73 246.6 0.3 4.9e-73 246.1 0.3 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDP44943.1 - 4.6e-31 108.3 0.0 9.1e-31 107.3 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EDP44943.1 - 4.5e-05 22.7 1.8 0.0028 16.8 0.8 2.4 3 0 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.12 EDP44943.1 - 0.00016 20.8 0.2 0.00047 19.3 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EDP44943.1 - 0.00025 19.9 0.7 0.054 12.2 0.2 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 EDP44943.1 - 0.00027 20.7 4.1 0.0026 17.4 1.8 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP44943.1 - 0.00036 19.9 0.0 0.0064 15.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EDP44943.1 - 0.00038 20.6 0.5 0.0012 19.0 0.5 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EDP44943.1 - 0.00051 19.4 0.0 0.06 12.6 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EDP44943.1 - 0.0039 16.5 1.0 0.089 12.0 0.1 2.6 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 EDP44943.1 - 0.0072 15.6 1.1 0.71 9.1 0.1 2.2 2 0 0 2 2 2 2 Thi4 family TrkA_N PF02254.18 EDP44943.1 - 0.049 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Maf PF02545.14 EDP44943.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Maf-like protein Pyr_redox PF00070.27 EDP44943.1 - 0.17 12.5 0.9 0.42 11.2 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EDP44944.1 - 2.4e-62 211.0 0.0 3.6e-62 210.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EDP44944.1 - 3.9e-33 115.0 0.0 1.2e-32 113.4 0.0 1.9 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EDP44944.1 - 6.4e-06 26.3 0.0 7.9e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EDP44944.1 - 1.5e-05 24.8 0.0 4.6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EDP44944.1 - 5e-05 22.7 0.1 0.0054 16.0 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDP44944.1 - 5.6e-05 22.4 0.2 0.00011 21.4 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EDP44944.1 - 5.7e-05 22.4 0.4 0.00063 18.9 0.6 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EDP44944.1 - 0.0012 18.1 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EDP44944.1 - 0.0096 14.7 0.6 0.092 11.4 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EDP44944.1 - 0.04 13.2 4.7 0.98 8.6 0.8 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EDP44944.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding UCR_TM PF02921.14 EDP44944.1 - 0.083 13.4 0.0 2.9 8.4 0.0 2.9 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region RWD PF05773.22 EDP44945.1 - 8.5e-09 35.7 0.0 1.5e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 RWD domain Pkinase PF00069.25 EDP44946.1 - 1.4e-18 67.2 0.6 2.3e-18 66.5 0.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP44946.1 - 4.4e-12 45.8 1.2 8.8e-12 44.9 1.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Sec23_helical PF04815.15 EDP44946.1 - 0.096 12.5 0.5 0.3 10.9 0.5 1.9 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Elf1 PF05129.13 EDP44947.1 - 2.2e-28 98.1 0.8 2.5e-28 97.9 0.8 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.15 EDP44947.1 - 0.54 10.4 3.7 11 6.1 0.1 2.4 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger RabGAP-TBC PF00566.18 EDP44948.1 - 1.5e-50 171.8 0.5 2.2e-50 171.3 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 EDP44948.1 - 7.7e-07 29.0 0.0 1.9e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 GRAM domain FA_hydroxylase PF04116.13 EDP44949.1 - 4.1e-17 62.8 12.7 4.7e-17 62.6 12.7 1.0 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Aa_trans PF01490.18 EDP44950.1 - 2.4e-79 266.9 36.9 3e-79 266.6 36.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NTF2 PF02136.20 EDP44952.1 - 1.8e-07 31.8 0.1 5.3e-06 27.0 0.0 2.7 2 1 0 3 3 3 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 EDP44952.1 - 1.1e-06 28.7 0.0 2.2e-06 27.7 0.0 1.5 2 0 0 2 2 2 1 Nuclear pore RNA shuttling protein Mtr2 DUF383 PF04063.14 EDP44953.1 - 5.1e-58 195.9 0.0 2.2e-57 193.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EDP44953.1 - 9.9e-18 63.7 1.4 3.4e-17 62.0 1.4 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Ribosomal_L34 PF00468.17 EDP44954.1 - 1.7e-18 66.3 8.3 2.6e-18 65.7 8.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L34 Ank_2 PF12796.7 EDP44956.1 - 1.8e-30 105.4 0.1 1.5e-11 44.7 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) DHHC PF01529.20 EDP44956.1 - 3.2e-27 95.2 10.5 3.2e-27 95.2 10.5 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 EDP44956.1 - 7.8e-24 83.4 3.7 3.8e-09 36.6 0.1 4.7 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EDP44956.1 - 2.8e-23 81.3 6.7 1e-08 35.2 0.1 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EDP44956.1 - 9.2e-23 80.3 7.4 8.4e-09 35.8 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EDP44956.1 - 5.5e-21 72.4 3.6 8.7e-07 28.8 0.1 5.7 5 0 0 5 5 5 4 Ankyrin repeat DUF3742 PF12553.8 EDP44956.1 - 0.47 10.6 4.2 7.5 6.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) Biotin_lipoyl PF00364.22 EDP44957.1 - 2.1e-20 72.3 0.3 4e-20 71.4 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EDP44957.1 - 8.6e-09 35.6 0.0 1.7e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 e3 binding domain DUF3446 PF11928.8 EDP44957.1 - 0.0019 18.4 7.8 0.0063 16.8 6.9 2.2 2 0 0 2 2 2 1 Early growth response N-terminal domain Biotin_lipoyl_2 PF13533.6 EDP44957.1 - 0.0051 16.6 0.0 0.036 13.9 0.0 2.1 2 0 0 2 2 2 1 Biotin-lipoyl like GP3_package PF16677.5 EDP44957.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 DNA-packaging protein gp3 Tma16 PF11176.8 EDP44957.1 - 0.026 14.4 0.2 0.046 13.6 0.2 1.3 1 0 0 1 1 1 0 Translation machinery-associated protein 16 QRPTase_N PF02749.16 EDP44957.1 - 0.13 12.3 0.1 0.97 9.5 0.0 2.3 2 1 1 3 3 3 0 Quinolinate phosphoribosyl transferase, N-terminal domain Plasmid_stab_B PF10784.9 EDP44957.1 - 0.13 12.1 0.0 0.37 10.7 0.0 1.7 1 0 0 1 1 1 0 Plasmid stability protein Diphthamide_syn PF01866.17 EDP44958.1 - 2.5e-66 224.2 0.8 1.3e-63 215.3 0.8 2.9 1 1 0 1 1 1 1 Putative diphthamide synthesis protein COQ7 PF03232.13 EDP44960.1 - 1.1e-41 142.5 0.2 1.5e-41 142.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EDP44960.1 - 0.0044 17.4 0.0 0.0078 16.6 0.0 1.5 1 1 0 1 1 1 1 Rubrerythrin Ferritin PF00210.24 EDP44960.1 - 0.036 14.0 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 Ferritin-like domain EAP30 PF04157.16 EDP44961.1 - 1.3e-35 122.8 0.0 1.6e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family IF2_N PF04760.15 EDP44961.1 - 0.037 13.8 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Mito_carr PF00153.27 EDP44962.1 - 5.8e-16 58.2 4.9 2.5e-07 30.5 0.6 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein Serine_protease PF18405.1 EDP44962.1 - 0.058 12.5 1.2 0.067 12.3 0.3 1.6 1 1 0 1 1 1 0 Gammaproteobacterial serine protease Dak1 PF02733.17 EDP44963.1 - 2.4e-93 312.4 0.8 3.6e-93 311.9 0.8 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EDP44963.1 - 3e-50 170.5 1.1 6.3e-50 169.5 1.1 1.6 1 0 0 1 1 1 1 DAK2 domain Flu_M1_C PF08289.11 EDP44963.1 - 0.098 12.9 0.0 0.45 10.8 0.0 2.1 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Pep3_Vps18 PF05131.14 EDP44964.1 - 3.1e-25 88.7 0.0 2.3e-24 85.9 0.0 2.4 3 0 0 3 3 3 1 Pep3/Vps18/deep orange family zf-RING_5 PF14634.6 EDP44964.1 - 0.0044 16.9 0.4 0.0044 16.9 0.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Clathrin PF00637.20 EDP44964.1 - 0.0051 16.7 0.3 0.1 12.5 0.1 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS DUF2175 PF09943.9 EDP44964.1 - 0.0061 16.8 0.0 0.025 14.9 0.0 2.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_11 PF17123.5 EDP44964.1 - 0.0066 16.2 0.3 0.0066 16.2 0.3 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EDP44964.1 - 0.011 15.5 1.0 0.011 15.5 1.0 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDP44964.1 - 0.018 15.4 1.6 0.058 13.7 0.3 2.4 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDP44964.1 - 0.02 14.9 0.3 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Vps39_2 PF10367.9 EDP44964.1 - 0.026 15.0 0.0 0.3 11.5 0.0 2.5 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 FlaC_arch PF05377.11 EDP44964.1 - 0.031 14.7 0.7 0.13 12.6 0.3 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EDP44964.1 - 0.15 12.1 0.0 0.49 10.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-RING_2 PF13639.6 EDP44964.1 - 0.24 11.8 9.0 0.067 13.5 1.4 3.4 3 0 0 3 3 2 0 Ring finger domain zf-C3HC4 PF00097.25 EDP44964.1 - 0.24 11.3 3.1 0.18 11.7 0.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 EDP44964.1 - 3.3 8.0 6.2 0.7 10.1 0.2 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C3H2C3 PF17122.5 EDP44964.1 - 9.8 6.3 6.6 0.46 10.5 0.5 2.0 2 0 0 2 2 1 0 Zinc-finger WD40 PF00400.32 EDP44965.1 - 1.2e-06 29.1 3.0 3.6 8.6 0.0 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat SRA1 PF07304.11 EDP44965.1 - 0.00048 19.9 0.0 0.00048 19.9 0.0 3.9 3 0 0 3 3 3 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EDP44965.1 - 0.025 14.2 0.2 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 Tail_spike_N PF18668.1 EDP44965.1 - 3.1 7.7 4.5 49 3.9 1.8 2.8 2 0 0 2 2 2 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Ssl1 PF04056.14 EDP44966.1 - 2.1e-61 207.1 0.0 2.9e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EDP44966.1 - 6.3e-16 58.4 7.5 6.3e-16 58.4 7.5 2.5 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EDP44966.1 - 1.9e-07 31.7 0.0 3.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-HIT PF04438.16 EDP44966.1 - 0.021 14.7 0.8 0.021 14.7 0.8 4.2 5 0 0 5 5 5 0 HIT zinc finger zinc_ribbon_15 PF17032.5 EDP44966.1 - 0.86 10.4 14.3 2.7 8.8 1.8 2.6 2 1 0 2 2 2 0 zinc-ribbon family DZR PF12773.7 EDP44966.1 - 1.8 8.6 24.8 1.8e+04 -5.0 24.8 3.5 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 EDP44966.1 - 3.9 7.4 22.0 0.61 10.0 2.1 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_S27 PF01599.19 EDP44966.1 - 6.5 7.0 10.9 0.5 10.6 0.6 3.4 2 2 1 3 3 3 0 Ribosomal protein S27a ThrE PF06738.12 EDP44967.1 - 1.3e-55 188.4 4.2 1.3e-55 188.4 4.2 1.7 2 0 0 2 2 2 1 Putative threonine/serine exporter ThrE_2 PF12821.7 EDP44967.1 - 3.1e-05 24.1 9.9 0.0011 19.1 0.1 3.5 3 0 0 3 3 3 2 Threonine/Serine exporter, ThrE zf-CHCC PF10276.9 EDP44968.1 - 2e-17 62.9 1.5 3.4e-17 62.2 1.5 1.4 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 EDP44968.1 - 0.12 12.1 1.0 3.4 7.5 0.1 2.4 2 0 0 2 2 2 0 Zinc Finger domain zf-C2HC_2 PF13913.6 EDP44968.1 - 0.5 10.3 2.7 15 5.6 1.5 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Chromate_transp PF02417.15 EDP44969.1 - 0.067 13.3 5.0 0.089 12.9 5.0 1.1 1 0 0 1 1 1 0 Chromate transporter Ribophorin_I PF04597.14 EDP44970.1 - 3.4e-104 349.5 0.0 3.9e-104 349.3 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I RRM_1 PF00076.22 EDP44971.1 - 3e-17 62.2 0.0 4.8e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF724 PF05266.14 EDP44971.1 - 0.0079 16.0 2.9 0.011 15.6 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF724) OPA3 PF07047.12 EDP44972.1 - 5.1e-43 145.8 1.2 7.6e-43 145.3 1.2 1.3 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Aminotran_5 PF00266.19 EDP44973.1 - 9e-85 284.8 0.0 2.2e-84 283.5 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EDP44973.1 - 0.0021 17.4 0.1 0.0041 16.5 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase EB1 PF03271.17 EDP44974.1 - 1.6e-15 57.0 0.4 3.8e-15 55.9 0.1 1.8 2 0 0 2 2 2 1 EB1-like C-terminal motif DUF3138 PF11336.8 EDP44974.1 - 0.11 11.0 0.4 0.15 10.6 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) WD40 PF00400.32 EDP44975.1 - 3.4e-30 103.6 9.4 5.3e-06 27.1 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP44975.1 - 5.6e-19 68.2 0.0 0.00027 21.2 0.0 6.2 1 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EDP44975.1 - 0.016 15.1 0.1 2.7 8.1 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EDP44975.1 - 0.032 14.1 0.0 22 4.9 0.0 3.3 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EDP44975.1 - 0.16 9.9 0.0 2 6.3 0.0 2.5 3 0 0 3 3 3 0 IKI3 family MIS13 PF08202.11 EDP44976.1 - 1.1e-19 70.8 7.8 3.7e-19 69.1 1.0 2.4 2 0 0 2 2 2 2 Mis12-Mtw1 protein family DUF1664 PF07889.12 EDP44976.1 - 0.038 14.0 3.6 0.16 12.0 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PT-VENN PF04829.13 EDP44976.1 - 0.43 10.7 4.0 6.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif HA2 PF04408.23 EDP44977.1 - 5.8e-15 55.5 0.2 1.6e-14 54.1 0.0 1.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDP44977.1 - 6.2e-15 55.5 0.0 2.1e-14 53.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain dsrm PF00035.26 EDP44977.1 - 7.1e-08 33.0 0.0 0.0018 18.9 0.0 3.0 2 0 0 2 2 2 2 Double-stranded RNA binding motif OB_NTP_bind PF07717.16 EDP44977.1 - 4.8e-06 26.8 0.1 1.8e-05 25.0 0.1 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDP44977.1 - 1.1e-05 25.3 0.1 3e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Retinin_C PF04527.12 EDP44977.1 - 0.63 10.3 3.3 7.5 6.9 3.1 2.4 2 0 0 2 2 2 0 Drosophila Retinin like protein ATE_C PF04377.15 EDP44978.1 - 5.6e-31 107.9 0.3 9.5e-31 107.2 0.3 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EDP44978.1 - 1.4e-27 95.9 3.4 2.9e-27 94.8 3.4 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus LRR_6 PF13516.6 EDP44979.1 - 4.5e-06 26.3 5.3 0.021 14.8 0.1 5.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 EDP44979.1 - 0.084 13.3 3.2 0.97 10.0 0.0 3.8 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) CTP_transf_like PF01467.26 EDP44980.1 - 1.4e-08 35.0 0.0 4.6e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 Cytidylyltransferase-like WD40 PF00400.32 EDP44980.1 - 2.1e-07 31.5 20.5 0.026 15.4 0.3 7.2 8 0 0 8 8 8 3 WD domain, G-beta repeat FAD_syn PF06574.12 EDP44980.1 - 0.1 12.4 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 FAD synthetase zf-rbx1 PF12678.7 EDP44981.1 - 2.1e-25 88.8 11.2 4.2e-25 87.8 11.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EDP44981.1 - 1.3e-17 63.6 11.7 1.9e-17 63.1 11.7 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDP44981.1 - 3.8e-06 27.1 16.8 3.9e-05 23.9 14.0 2.6 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP44981.1 - 1.3e-05 25.0 1.8 1.3e-05 25.0 1.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP44981.1 - 0.00076 19.3 12.0 0.014 15.2 12.0 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP44981.1 - 0.021 14.7 10.4 0.27 11.1 3.7 2.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EDP44981.1 - 0.19 11.4 14.1 0.092 12.4 4.3 2.5 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EDP44981.1 - 0.85 9.8 13.9 0.099 12.8 8.4 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EDP44981.1 - 2.4 8.2 11.6 0.57 10.3 7.4 2.2 2 1 0 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 EDP44981.1 - 3.1 7.6 20.5 71 3.3 17.3 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 EDP44981.1 - 6.9 6.7 11.1 45 4.1 11.2 2.4 1 1 1 2 2 2 0 zinc-RING finger domain HA2 PF04408.23 EDP44982.1 - 2.7e-21 75.9 0.6 1.1e-20 74.0 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDP44982.1 - 1.1e-20 73.8 0.1 2.8e-20 72.4 0.1 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDP44982.1 - 5.6e-15 55.7 0.0 1.2e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EDP44982.1 - 6.4e-06 26.0 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EDP44982.1 - 3.1e-05 24.3 0.0 9.5e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP44982.1 - 0.00021 21.0 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EDP44982.1 - 0.00058 19.0 0.0 0.0011 18.0 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EDP44982.1 - 0.0025 18.2 0.0 0.0061 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EDP44982.1 - 0.0028 17.3 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EDP44982.1 - 0.011 16.2 0.2 0.13 12.8 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 EDP44982.1 - 0.034 14.5 0.4 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EDP44982.1 - 0.038 13.4 0.2 0.34 10.2 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family PhoH PF02562.16 EDP44982.1 - 0.091 12.2 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EDP44982.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC zf-HC5HC2H_2 PF13832.6 EDP44983.1 - 6.8e-32 109.9 7.4 6.8e-32 109.9 7.4 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EDP44983.1 - 3.4e-24 84.9 5.9 3.4e-24 84.9 5.9 3.1 3 0 0 3 3 3 2 PHD-like zinc-binding domain Bromodomain PF00439.25 EDP44983.1 - 1.9e-23 82.3 0.1 3.9e-23 81.3 0.1 1.6 1 0 0 1 1 1 1 Bromodomain EPL1 PF10513.9 EDP44983.1 - 7.9e-21 75.1 2.6 7.9e-21 75.1 2.6 1.8 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD_2 PF13831.6 EDP44983.1 - 3.6e-15 55.2 1.7 3.6e-15 55.2 1.7 3.0 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EDP44983.1 - 6.7e-09 35.5 8.8 6.7e-09 35.5 8.8 3.1 4 0 0 4 4 4 2 PHD-finger C1_1 PF00130.22 EDP44983.1 - 0.0095 15.8 1.7 0.0095 15.8 1.7 3.2 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 EDP44983.1 - 0.012 15.2 2.4 0.012 15.2 2.4 2.7 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_3 PF13922.6 EDP44983.1 - 0.42 11.0 6.5 1.7 9.1 6.5 2.1 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx zf-RING-like PF08746.11 EDP44983.1 - 6.1 7.2 21.6 4.2 7.8 8.2 2.9 2 1 0 2 2 2 0 RING-like domain AAA PF00004.29 EDP44984.1 - 5.3e-48 162.8 0.0 6.9e-42 143.0 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP44984.1 - 1.2e-08 34.6 0.0 5.3e-08 32.5 0.0 2.2 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EDP44984.1 - 1.2e-07 32.2 5.4 5.6e-05 23.6 0.0 3.8 4 1 0 4 4 2 2 AAA ATPase domain IstB_IS21 PF01695.17 EDP44984.1 - 1.4e-07 31.5 0.0 0.00021 21.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_2 PF07724.14 EDP44984.1 - 6.6e-06 26.4 0.0 5.2e-05 23.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDP44984.1 - 6e-05 23.1 0.0 0.0098 15.9 0.0 3.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDP44984.1 - 7.3e-05 23.1 0.7 0.11 12.8 0.1 4.5 3 1 0 3 3 3 1 AAA domain Bromodomain PF00439.25 EDP44984.1 - 0.00061 19.8 0.2 0.0014 18.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain YL1 PF05764.13 EDP44984.1 - 0.0011 19.2 9.3 0.0011 19.2 9.3 2.3 2 0 0 2 2 2 1 YL1 nuclear protein AAA_33 PF13671.6 EDP44984.1 - 0.0012 19.0 0.8 0.053 13.7 0.0 3.6 3 1 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EDP44984.1 - 0.0013 18.1 0.4 0.18 11.1 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 EDP44984.1 - 0.0022 18.1 0.0 0.16 12.1 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain RuvB_N PF05496.12 EDP44984.1 - 0.0023 17.7 0.0 0.64 9.8 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EDP44984.1 - 0.0048 17.5 0.8 0.052 14.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 EDP44984.1 - 0.016 14.9 0.0 0.65 9.7 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EDP44984.1 - 0.02 14.0 0.0 2.1 7.4 0.0 2.6 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 EDP44984.1 - 0.026 14.9 0.0 0.14 12.6 0.0 2.3 2 0 0 2 2 1 0 RNA helicase TIP49 PF06068.13 EDP44984.1 - 0.035 13.3 0.0 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_11 PF13086.6 EDP44984.1 - 0.041 13.7 4.6 0.25 11.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EDP44984.1 - 0.047 13.3 0.2 0.28 10.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP44984.1 - 0.066 13.7 0.0 0.47 11.0 0.0 2.5 2 0 0 2 2 1 0 ABC transporter PhoH PF02562.16 EDP44984.1 - 0.068 12.6 0.0 0.44 10.0 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EDP44984.1 - 0.082 12.4 0.0 0.32 10.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Torsin PF06309.11 EDP44984.1 - 0.087 12.9 0.0 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Torsin DnaJ_C PF01556.18 EDP44985.1 - 9.5e-36 123.1 0.0 1.3e-35 122.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDP44985.1 - 9e-26 89.8 3.4 1.4e-25 89.2 3.4 1.3 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EDP44985.1 - 0.13 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein HTH_10 PF04967.12 EDP44985.1 - 0.29 10.9 0.7 20 5.1 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain Ribosomal_L7Ae PF01248.26 EDP44986.1 - 5.4e-27 93.4 0.2 6.9e-27 93.0 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EDP44986.1 - 0.0019 18.0 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EDP44986.1 - 0.0091 16.1 0.1 0.011 15.8 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 RabGAP-TBC PF00566.18 EDP44988.1 - 1.9e-16 60.4 0.0 4.8e-16 59.1 0.0 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain CRAL_TRIO PF00650.20 EDP44989.1 - 2.5e-27 95.5 0.0 3.8e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDP44989.1 - 1.8e-06 28.2 0.0 2.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EDP44989.1 - 2.7e-06 27.5 0.6 2.7e-06 27.5 0.6 2.2 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain Ntox46 PF15538.6 EDP44989.1 - 0.043 13.8 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 46 ATP-synt_C PF00137.21 EDP44989.1 - 3.3 8.1 14.0 0.13 12.6 1.5 2.4 2 0 0 2 2 2 0 ATP synthase subunit C Lipase_3 PF01764.25 EDP44990.1 - 3.9e-23 81.9 0.0 5.7e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EDP44990.1 - 9.2e-06 25.1 0.0 1.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 EDP44990.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF676 PF05057.14 EDP44990.1 - 0.01 15.3 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EDP44990.1 - 0.014 16.0 0.0 0.016 15.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.13 EDP44990.1 - 0.017 14.8 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF726 PF05277.12 EDP44990.1 - 0.029 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF2974 PF11187.8 EDP44990.1 - 0.042 13.4 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 EDP44990.1 - 0.057 13.1 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein PAF-AH_p_II PF03403.13 EDP44990.1 - 0.06 11.9 0.0 0.085 11.4 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Lipase_3 PF01764.25 EDP44991.1 - 3.2e-26 91.9 0.0 4.3e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EDP44991.1 - 0.0025 17.1 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 EDP44991.1 - 0.039 12.5 0.0 0.056 11.9 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DUF2974 PF11187.8 EDP44991.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EDP44992.1 - 1.2e-24 86.8 0.0 1.7e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EDP44992.1 - 5.7e-06 25.8 0.0 8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PAF-AH_p_II PF03403.13 EDP44992.1 - 0.00055 18.6 0.0 0.0008 18.0 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.7 EDP44992.1 - 0.0017 19.0 0.0 0.0023 18.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EDP44992.1 - 0.013 15.0 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EDP44992.1 - 0.015 15.0 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EDP44993.1 - 7.2e-22 77.8 0.0 1.1e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EDP44993.1 - 0.00044 19.6 0.0 0.00062 19.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EDP44993.1 - 0.0013 19.4 0.1 0.0031 18.1 0.0 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF3089 PF11288.8 EDP44993.1 - 0.0078 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) FSH1 PF03959.13 EDP44993.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 EDP44993.1 - 0.04 13.6 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 EDP44993.1 - 0.047 12.2 0.0 0.067 11.7 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DUF676 PF05057.14 EDP44993.1 - 0.047 13.2 0.0 0.061 12.8 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 EDP44993.1 - 0.049 13.4 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 EDP44993.1 - 0.057 13.1 0.0 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein Lipase_2 PF01674.18 EDP44993.1 - 0.058 12.9 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) DUF2974 PF11187.8 EDP44993.1 - 0.071 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) VirJ PF06057.11 EDP44993.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) AXE1 PF05448.12 EDP44993.1 - 0.16 10.6 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) PFK PF00365.20 EDP44994.1 - 1.3e-165 549.6 0.1 2.3e-86 289.7 0.0 2.6 2 1 0 2 2 2 2 Phosphofructokinase PapJ PF14855.6 EDP44994.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone Wtap PF17098.5 EDP44995.1 - 0.0019 18.1 6.9 0.031 14.2 1.6 2.2 1 1 1 2 2 2 2 WTAP/Mum2p family Mu-like_Pro PF10123.9 EDP44995.1 - 0.049 13.2 0.5 0.059 12.9 0.5 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein bZIP_1 PF00170.21 EDP44995.1 - 0.053 13.6 3.4 0.062 13.4 1.6 2.1 2 1 0 2 2 2 0 bZIP transcription factor JIP_LZII PF16471.5 EDP44995.1 - 0.32 11.2 7.1 0.26 11.5 4.6 2.0 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Adaptin_binding PF10199.9 EDP44995.1 - 0.45 11.1 3.8 0.61 10.7 3.7 1.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Arf PF00025.21 EDP44996.1 - 5.3e-27 94.4 0.1 4.5e-14 52.3 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EDP44996.1 - 6.5e-07 29.6 0.0 6e-06 26.5 0.0 2.2 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EDP44996.1 - 5.1e-06 26.2 0.0 0.00041 20.0 0.0 2.1 2 0 0 2 2 2 2 Ras family G-alpha PF00503.20 EDP44996.1 - 0.0011 18.2 0.0 0.0033 16.6 0.0 1.7 2 0 0 2 2 2 1 G-protein alpha subunit PLATZ PF04640.14 EDP44996.1 - 0.06 14.0 0.5 0.21 12.2 0.1 1.9 2 0 0 2 2 2 0 PLATZ transcription factor Gtr1_RagA PF04670.12 EDP44996.1 - 0.09 12.1 0.0 0.12 11.7 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2370 PF10176.9 EDP44997.1 - 9e-55 185.8 1.3 1.1e-52 179.0 1.3 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2370) DUF410 PF04190.13 EDP44998.1 - 1.1e-47 163.0 1.4 3.7e-47 161.3 1.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF410) TPR_14 PF13428.6 EDP44998.1 - 0.063 14.1 0.4 0.063 14.1 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PROCN PF08083.11 EDP44999.1 - 1e-229 762.2 8.3 1.6e-229 761.6 8.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EDP44999.1 - 3e-125 416.4 0.3 5.3e-125 415.6 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EDP44999.1 - 1.4e-86 288.4 3.1 2e-86 287.9 0.8 2.4 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EDP44999.1 - 1.2e-84 281.7 5.1 3e-84 280.5 3.1 2.6 3 0 0 3 3 3 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EDP44999.1 - 2.2e-70 235.0 0.0 4.1e-70 234.1 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EDP44999.1 - 1.1e-45 153.9 0.4 2.5e-45 152.7 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EDP44999.1 - 4.9e-36 123.4 0.0 9.4e-36 122.4 0.0 1.5 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 EDP44999.1 - 0.002 18.1 0.0 0.0045 17.0 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MDM10 PF12519.8 EDP45000.1 - 8.3e-25 87.6 0.0 2.4e-24 86.1 0.0 1.7 1 1 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 DUF3402 PF11882.8 EDP45001.1 - 4.4e-109 365.7 0.2 7.2e-106 355.1 0.0 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EDP45001.1 - 9.2e-25 87.4 0.0 1.8e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 N1221-like protein IQCJ-SCHIP1 PF15157.6 EDP45001.1 - 0.23 11.3 1.1 0.67 9.8 1.1 1.7 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif DDOST_48kD PF03345.14 EDP45002.1 - 3.9e-116 388.3 0.0 4.6e-116 388.1 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Diphthami_syn_2 PF01902.17 EDP45003.1 - 0.00091 18.8 0.0 0.0093 15.5 0.0 1.9 2 0 0 2 2 2 1 Diphthamide synthase SUV3_C PF12513.8 EDP45004.1 - 5.5e-16 58.2 0.5 1.1e-15 57.3 0.5 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EDP45004.1 - 1.1e-11 45.0 0.0 2.6e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Bromo_TP PF07524.13 EDP45005.1 - 1.1e-05 25.4 0.2 1.9e-05 24.6 0.2 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 EDP45005.1 - 0.00055 20.0 0.1 0.0011 19.0 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.5 EDP45005.1 - 0.22 11.7 0.1 0.36 11.0 0.1 1.2 1 0 0 1 1 1 0 Histone-fold protein DUF3808 PF10300.9 EDP45006.1 - 2.4e-23 82.7 0.2 3.2e-23 82.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EDP45006.1 - 2.2e-06 27.3 6.4 0.0015 18.5 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EDP45006.1 - 0.00013 21.6 4.5 0.022 14.5 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDP45006.1 - 0.00035 21.0 0.4 0.026 15.0 0.0 3.1 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EDP45006.1 - 0.00069 20.1 2.9 0.044 14.4 0.1 3.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EDP45006.1 - 0.0015 18.5 0.2 0.026 14.7 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 EDP45006.1 - 0.0016 18.9 1.5 0.16 12.6 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EDP45006.1 - 0.0054 16.7 2.0 0.29 11.2 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EDP45006.1 - 0.0057 17.4 0.2 0.39 11.7 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EDP45006.1 - 0.013 15.4 3.5 0.25 11.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EDP45006.1 - 0.031 14.9 1.1 1.5 9.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDP45006.1 - 0.042 14.0 1.4 0.87 9.8 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDP45006.1 - 0.056 13.8 10.0 0.074 13.3 0.2 3.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EDP45006.1 - 0.059 13.1 1.2 4.6 7.0 0.0 2.4 2 0 0 2 2 2 0 TPR repeat TPR_17 PF13431.6 EDP45006.1 - 0.088 13.2 1.1 3.9 8.1 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP45006.1 - 2.4 8.5 7.0 11 6.3 0.3 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3808 PF10300.9 EDP45007.1 - 4.2e-33 114.8 0.0 1.9e-32 112.6 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) Peptidase_S10 PF00450.22 EDP45008.1 - 2.5e-78 264.4 1.4 3.4e-78 263.9 1.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF3801 PF12687.7 EDP45008.1 - 0.03 14.4 0.1 0.057 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Polysacc_deac_1 PF01522.21 EDP45009.1 - 6.6e-27 93.9 0.0 1.1e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase RusA PF05866.11 EDP45009.1 - 0.1 13.1 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA 3Beta_HSD PF01073.19 EDP45010.1 - 8.7e-22 77.4 0.0 1.8e-21 76.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP45010.1 - 1.2e-20 74.1 0.5 2.8e-20 72.8 0.5 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EDP45010.1 - 6.6e-16 58.7 0.0 1.3e-15 57.8 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EDP45010.1 - 3e-12 46.6 0.5 1e-11 44.9 0.6 1.7 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 EDP45010.1 - 3.1e-12 46.2 0.0 1.6e-06 27.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EDP45010.1 - 3.3e-12 46.5 1.1 8.8e-12 45.1 0.7 1.9 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EDP45010.1 - 5.4e-12 45.4 0.3 1.1e-11 44.5 0.2 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EDP45010.1 - 6.1e-07 29.1 1.5 2.9e-06 26.9 0.1 2.6 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EDP45010.1 - 8.4e-05 22.6 0.0 0.00069 19.6 0.0 2.0 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EDP45010.1 - 0.00022 20.4 1.0 0.0012 18.0 0.4 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 EDP45010.1 - 0.011 16.2 0.1 0.028 14.9 0.1 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EDP45010.1 - 0.095 12.8 0.2 0.36 11.0 0.2 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 EDP45010.1 - 0.13 12.5 0.2 0.36 11.1 0.1 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 EDP45010.1 - 0.17 11.8 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Erf4 PF10256.9 EDP45011.1 - 0.00039 20.5 0.0 0.00073 19.6 0.0 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF4646 PF15496.6 EDP45011.1 - 0.096 13.3 0.0 0.28 11.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4646) ADH_zinc_N PF00107.26 EDP45012.1 - 1.7e-16 60.4 0.1 2.7e-16 59.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EDP45012.1 - 2.4e-15 56.3 1.0 2.4e-15 56.3 1.0 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EDP45012.1 - 1.6e-05 25.9 0.0 2.6e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase WD40 PF00400.32 EDP45013.1 - 0.0022 18.8 15.1 0.66 10.9 0.4 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45013.1 - 0.0031 17.8 1.8 0.43 10.9 0.1 4.3 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PACT_coil_coil PF10495.9 EDP45014.1 - 0.00042 20.8 0.1 0.00042 20.8 0.1 3.6 4 1 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein GAS PF13851.6 EDP45014.1 - 0.014 14.7 47.3 0.017 14.5 3.8 3.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 EDP45014.1 - 1.3 9.4 40.5 0.51 10.7 8.0 5.9 4 1 1 5 5 5 0 Uncharacterized conserved protein Hydrolase_3 PF08282.12 EDP45014.1 - 2 8.1 8.2 1.6 8.4 3.8 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Fib_alpha PF08702.10 EDP45014.1 - 3.7 7.7 38.5 0.033 14.4 5.3 4.7 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EDP45014.1 - 5.5 7.0 31.6 1.8 8.6 4.6 5.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) ADIP PF11559.8 EDP45015.1 - 5.5e-14 52.5 16.7 5.5e-14 52.5 16.7 2.2 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding DUF1515 PF07439.11 EDP45015.1 - 0.4 10.7 3.3 0.26 11.3 0.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) E1-E2_ATPase PF00122.20 EDP45016.1 - 6.6e-29 100.7 0.0 1.6e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 EDP45016.1 - 1.7e-26 92.8 0.0 3.3e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 EDP45016.1 - 5.2e-16 59.6 0.1 2.2e-08 34.7 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EDP45016.1 - 3.5e-06 27.0 0.0 9.3e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 EDP45016.1 - 0.00013 21.8 9.9 0.00013 21.8 9.9 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 EDP45016.1 - 0.00023 20.8 0.0 0.00048 19.8 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus tRNA_bind PF01588.20 EDP45017.1 - 3.9e-26 91.0 0.0 6e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EDP45017.1 - 0.00011 22.2 0.0 0.00021 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EDP45017.1 - 0.00026 21.1 0.3 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EDP45017.1 - 0.00043 20.0 0.0 0.00092 19.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EDP45017.1 - 0.02 15.1 0.0 0.045 14.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UDPGP PF01704.18 EDP45018.1 - 3.8e-49 167.4 0.0 4.8e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EDP45018.1 - 0.0015 19.0 0.0 0.0045 17.4 0.0 1.8 2 0 0 2 2 2 1 MobA-like NTP transferase domain DUF3510 PF12022.8 EDP45019.1 - 1.2e-21 77.3 0.0 4.5e-21 75.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) COG2 PF06148.11 EDP45019.1 - 2.8e-16 59.8 0.3 8e-16 58.3 0.2 1.8 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EDP45019.1 - 0.0052 16.8 1.3 0.014 15.4 0.3 2.4 2 0 0 2 2 2 1 Vps51/Vps67 CAP59_mtransfer PF11735.8 EDP45020.1 - 4.5e-71 239.3 0.0 5.7e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 7TMR-DISM_7TM PF07695.11 EDP45020.1 - 0.061 13.2 2.0 0.099 12.5 2.0 1.3 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF2711 PF10924.8 EDP45020.1 - 0.096 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2711) DUF2678 PF10856.8 EDP45020.1 - 0.25 11.3 1.8 0.44 10.5 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) Pkinase PF00069.25 EDP45021.1 - 7.5e-71 238.6 0.0 1.2e-70 237.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45021.1 - 2.8e-47 161.2 0.0 4.2e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EDP45021.1 - 2.4e-21 75.8 0.0 5.3e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EDP45021.1 - 2.4e-07 29.9 0.0 4.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP45021.1 - 1.1e-05 25.0 0.3 2.8e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EDP45021.1 - 0.0051 15.8 0.1 0.0089 15.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EDP45021.1 - 0.059 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EDP45021.1 - 0.15 11.4 0.0 0.55 9.6 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EDP45021.1 - 0.18 11.4 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DSHCT PF08148.12 EDP45021.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Rad9 PF04139.13 EDP45022.1 - 3.5e-38 131.5 0.0 4.6e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Rad9 Trp_syntA PF00290.20 EDP45023.1 - 1.1e-74 250.6 0.0 1.7e-74 249.9 0.0 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EDP45023.1 - 3.3e-45 154.7 0.8 5.5e-45 154.0 0.8 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Symplekin_C PF12295.8 EDP45024.1 - 1.9e-48 165.0 0.5 5.7e-48 163.5 0.5 1.9 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 EDP45024.1 - 2.3e-36 125.5 0.0 6.5e-36 124.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) V-ATPase_G PF03179.15 EDP45025.1 - 2.1e-28 98.9 19.0 2.4e-28 98.7 19.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 EDP45025.1 - 0.00021 20.8 19.6 0.00024 20.6 19.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 EDP45025.1 - 0.00034 20.7 9.1 0.00034 20.7 9.1 2.1 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) Muted PF14942.6 EDP45025.1 - 0.021 15.1 12.2 0.028 14.7 12.2 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF842 PF05811.13 EDP45025.1 - 0.026 14.2 2.3 0.034 13.8 2.3 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) HrpE PF06188.12 EDP45025.1 - 0.046 13.6 3.2 0.069 13.0 3.2 1.3 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E Histidinol_dh PF00815.20 EDP45025.1 - 0.048 12.7 3.9 0.059 12.4 3.9 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase Peptidase_S46 PF10459.9 EDP45025.1 - 0.058 12.0 7.5 0.064 11.9 7.5 1.0 1 0 0 1 1 1 0 Peptidase S46 PhoU PF01895.19 EDP45025.1 - 0.058 13.9 1.2 0.37 11.3 0.0 2.1 2 0 0 2 2 2 0 PhoU domain DUF3435 PF11917.8 EDP45025.1 - 0.071 12.0 8.6 0.082 11.8 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) Phasin PF05597.11 EDP45025.1 - 0.09 12.8 10.4 0.2 11.7 10.3 1.7 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF883 PF05957.13 EDP45025.1 - 0.095 13.3 7.9 0.34 11.5 6.8 2.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) PIN_8 PF18476.1 EDP45025.1 - 0.14 12.0 8.9 0.16 11.8 8.9 1.1 1 0 0 1 1 1 0 PIN like domain V-ATPase_G_2 PF16999.5 EDP45025.1 - 0.18 12.2 15.6 0.33 11.4 15.6 1.5 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit ECH_2 PF16113.5 EDP45025.1 - 0.38 10.2 4.3 0.42 10.0 4.3 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF4065 PF13274.6 EDP45025.1 - 0.4 11.6 8.7 1.2 10.0 8.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) vATP-synt_E PF01991.18 EDP45025.1 - 0.43 9.9 16.5 0.55 9.6 16.5 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit She9_MDM33 PF05546.11 EDP45025.1 - 0.49 10.2 12.3 0.72 9.6 12.3 1.2 1 0 0 1 1 1 0 She9 / Mdm33 family Retrotrans_gag PF03732.17 EDP45025.1 - 0.51 10.6 5.3 1.1 9.6 4.6 1.8 1 1 1 2 2 2 0 Retrotransposon gag protein RRF PF01765.19 EDP45025.1 - 0.6 10.1 15.3 1.2 9.1 15.3 1.6 1 1 0 1 1 1 0 Ribosome recycling factor Ribosomal_L12 PF00542.19 EDP45025.1 - 0.68 10.3 12.9 0.82 10.1 0.7 2.7 1 1 2 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain GCP_C_terminal PF04130.13 EDP45025.1 - 0.68 9.3 6.5 1.3 8.4 6.5 1.5 1 1 0 1 1 1 0 Gamma tubulin complex component C-terminal AHSP PF09236.10 EDP45025.1 - 0.73 10.3 5.9 0.69 10.4 1.2 2.1 1 1 1 2 2 2 0 Alpha-haemoglobin stabilising protein TetR_C_23 PF17931.1 EDP45025.1 - 0.75 9.9 7.3 0.89 9.7 6.5 1.5 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain YgaB PF14182.6 EDP45025.1 - 0.77 10.2 13.5 0.076 13.4 5.6 2.2 1 1 1 2 2 2 0 YgaB-like protein Exonuc_VII_L PF02601.15 EDP45025.1 - 0.96 9.0 9.3 1 8.8 9.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 EDP45025.1 - 0.97 8.6 10.8 1.2 8.3 10.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein Prominin PF05478.11 EDP45025.1 - 0.99 7.3 6.6 1.2 7.0 6.6 1.0 1 0 0 1 1 1 0 Prominin DUF3450 PF11932.8 EDP45025.1 - 1.2 8.4 12.1 1.3 8.3 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FapA PF03961.13 EDP45025.1 - 1.2 7.6 11.8 1.3 7.5 11.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 EDP45025.1 - 1.2 8.4 9.1 1.5 8.1 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 EDP45025.1 - 2 8.5 11.6 2.5 8.2 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) 5_nucleotid PF05761.14 EDP45025.1 - 3.7 6.3 8.4 4.8 6.0 8.4 1.2 1 0 0 1 1 1 0 5' nucleotidase family OmpH PF03938.14 EDP45025.1 - 4.1 7.7 19.4 5.6 7.3 19.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) LMBR1 PF04791.16 EDP45025.1 - 5.3 5.8 7.5 5.8 5.7 7.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Mt_ATP-synt_D PF05873.12 EDP45025.1 - 5.9 6.7 15.8 4.4 7.1 7.8 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Zip PF02535.22 EDP45025.1 - 6.6 5.9 4.9 7.1 5.7 4.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 EDP45025.1 - 9 4.9 6.4 10 4.8 6.4 1.0 1 0 0 1 1 1 0 Ureide permease WD40 PF00400.32 EDP45026.1 - 8.3e-05 23.3 0.1 0.00035 21.3 0.1 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat MutL_C PF08676.11 EDP45027.1 - 5.3e-20 71.7 0.0 1.4e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EDP45027.1 - 3.9e-19 68.5 0.0 1.3e-18 66.8 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EDP45027.1 - 6.3e-13 48.7 0.1 1.4e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EDP45027.1 - 2.8e-07 31.0 0.0 6.5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Dynamitin PF04912.14 EDP45028.1 - 0.00054 19.4 1.6 0.00072 19.0 1.6 1.2 1 0 0 1 1 1 1 Dynamitin TMEM151 PF14857.6 EDP45028.1 - 0.048 12.6 1.0 0.065 12.1 1.0 1.1 1 0 0 1 1 1 0 TMEM151 family Dynein_light PF01221.18 EDP45029.1 - 1.2e-33 115.2 0.2 1.5e-33 114.9 0.2 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Imm48 PF15574.6 EDP45029.1 - 0.075 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 48 IF-2B PF01008.17 EDP45030.1 - 3.4e-71 239.8 0.0 4.7e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family BAR PF03114.18 EDP45031.1 - 5.6e-28 98.2 2.1 8.5e-28 97.6 2.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EDP45031.1 - 6.5e-15 54.5 0.0 1e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP45031.1 - 2.2e-13 49.8 0.1 3.4e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP45031.1 - 9.1e-10 38.1 0.0 1.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain MPP6 PF10175.9 EDP45032.1 - 5.8e-09 36.6 5.4 1e-08 35.7 5.4 1.4 1 0 0 1 1 1 1 M-phase phosphoprotein 6 DUF4677 PF15726.5 EDP45032.1 - 0.35 11.0 0.1 0.35 11.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) PP_M1 PF03012.14 EDP45032.1 - 0.5 9.9 8.9 0.63 9.5 1.4 2.1 2 0 0 2 2 2 0 Phosphoprotein CENP-B_dimeris PF09026.10 EDP45032.1 - 2.5 8.6 13.0 1.4 9.4 0.6 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 EDP45032.1 - 4.4 7.0 10.9 2.8 7.6 3.1 2.2 2 0 0 2 2 2 0 FAM176 family RabGAP-TBC PF00566.18 EDP45033.1 - 4.3e-24 85.4 1.2 1e-23 84.2 1.2 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain SWI-SNF_Ssr4 PF08549.10 EDP45034.1 - 1.9e-08 33.4 0.1 1.9e-08 33.4 0.1 2.2 1 1 1 2 2 2 1 Fungal domain of unknown function (DUF1750) Borrelia_P83 PF05262.11 EDP45034.1 - 1.3 7.4 14.2 2.3 6.6 14.2 1.4 1 1 0 1 1 1 0 Borrelia P83/100 protein DnaJ PF00226.31 EDP45035.1 - 3.7e-21 75.0 0.3 5.4e-21 74.5 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain HEAT_EZ PF13513.6 EDP45036.1 - 1.9e-23 82.5 11.9 1.1e-06 28.9 0.0 10.6 9 2 2 11 11 11 3 HEAT-like repeat HEAT_2 PF13646.6 EDP45036.1 - 1.4e-16 60.6 21.3 0.00017 21.9 4.0 8.1 3 3 3 7 7 7 5 HEAT repeats HEAT PF02985.22 EDP45036.1 - 8.8e-13 47.3 17.8 0.0074 16.5 0.0 10.9 13 0 0 13 13 11 4 HEAT repeat UME PF08064.13 EDP45036.1 - 3.7e-07 30.0 7.0 0.41 10.6 0.0 6.5 6 2 2 8 8 8 2 UME (NUC010) domain Cnd1 PF12717.7 EDP45036.1 - 1e-06 28.9 3.4 0.26 11.3 0.0 5.0 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EDP45036.1 - 3.7e-06 26.8 1.5 2.2e-05 24.3 0.2 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EDP45036.1 - 3.8e-06 27.4 0.1 2.3 8.9 0.0 5.9 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region Ipi1_N PF12333.8 EDP45036.1 - 5.4e-06 26.9 0.5 0.83 10.3 0.0 5.5 4 2 2 6 6 6 1 Rix1 complex component involved in 60S ribosome maturation MMS19_C PF12460.8 EDP45036.1 - 3.5e-05 23.1 8.5 0.3 10.1 0.5 6.2 5 2 2 7 7 7 3 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EDP45036.1 - 0.00047 19.8 4.0 1.4 8.4 0.0 4.9 4 1 0 5 5 5 2 CLASP N terminal Xpo1 PF08389.12 EDP45036.1 - 0.00066 19.8 11.0 0.053 13.6 0.1 5.4 6 0 0 6 6 6 1 Exportin 1-like protein Cohesin_HEAT PF12765.7 EDP45036.1 - 0.0035 17.6 0.5 5.1 7.5 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion RIX1 PF08167.12 EDP45036.1 - 0.0067 16.2 3.6 0.34 10.6 0.0 3.9 3 1 0 4 4 4 1 rRNA processing/ribosome biogenesis MMS19_N PF14500.6 EDP45036.1 - 0.011 15.3 8.7 0.13 11.8 3.1 4.3 3 1 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II CTD_bind PF04818.13 EDP45036.1 - 0.031 15.1 0.1 90 4.0 0.0 5.1 3 1 1 4 4 4 0 RNA polymerase II-binding domain. U3snoRNP10 PF12397.8 EDP45036.1 - 0.088 13.2 7.4 12 6.3 0.1 5.0 4 2 0 5 5 5 0 U3 small nucleolar RNA-associated protein 10 Arm PF00514.23 EDP45036.1 - 0.88 9.7 8.5 35 4.6 0.0 5.7 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EDP45036.1 - 1.9 8.7 6.2 57 3.9 0.0 4.9 5 1 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Pkinase PF00069.25 EDP45037.1 - 3.6e-54 183.9 0.0 4.9e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45037.1 - 3.3e-20 72.4 0.0 5.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EDP45037.1 - 0.00095 19.1 0.1 0.006 16.5 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EDP45037.1 - 0.0031 17.1 0.3 0.0081 15.8 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EDP45037.1 - 0.088 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF5575 PF17738.1 EDP45037.1 - 0.1 11.6 0.2 0.19 10.7 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5575) Med4 PF10018.9 EDP45038.1 - 3.1e-18 66.2 7.8 3.1e-18 66.2 7.8 1.7 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 AAA_assoc_C PF09821.9 EDP45038.1 - 0.019 15.5 0.3 0.37 11.3 0.4 2.3 2 0 0 2 2 2 0 C-terminal AAA-associated domain Phage_holin_6_1 PF09682.10 EDP45038.1 - 0.3 11.5 1.5 4.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) G-patch PF01585.23 EDP45039.1 - 3e-09 36.6 0.4 4.5e-09 36.1 0.4 1.3 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EDP45039.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 EDP45040.1 - 3.8e-41 140.6 0.0 7e-41 139.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EDP45040.1 - 1.6e-20 72.8 0.0 3.3e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EDP45040.1 - 3.3e-11 42.8 0.2 1.1e-10 41.2 0.2 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EDP45040.1 - 4.4e-05 23.7 0.1 0.00055 20.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EDP45040.1 - 0.00012 22.1 1.8 0.00067 19.7 0.2 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP45040.1 - 0.00027 21.4 0.2 0.049 14.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EDP45040.1 - 0.00033 21.0 0.7 0.1 12.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EDP45040.1 - 0.00035 20.4 0.0 0.00087 19.1 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 EDP45040.1 - 0.0012 18.3 0.1 0.014 14.9 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 EDP45040.1 - 0.0098 16.1 0.2 0.02 15.1 0.0 1.8 2 1 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 EDP45040.1 - 0.017 14.5 0.0 0.047 13.1 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDP45040.1 - 0.02 15.0 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TMF_TATA_bd PF12325.8 EDP45040.1 - 0.026 14.7 2.5 0.026 14.7 2.5 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF815 PF05673.13 EDP45040.1 - 0.027 13.6 0.3 0.059 12.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 EDP45040.1 - 0.042 13.6 0.4 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDP45040.1 - 0.069 12.9 0.1 0.23 11.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EDP45040.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EDP45040.1 - 0.19 11.0 1.0 0.44 9.8 0.0 2.0 3 0 0 3 3 3 0 KaiC Kinesin PF00225.23 EDP45041.1 - 1.7e-95 319.8 0.0 2.4e-95 319.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDP45041.1 - 2.3e-21 76.3 0.0 5.3e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF4407 PF14362.6 EDP45041.1 - 0.16 11.3 4.5 0.38 10.1 4.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FUSC PF04632.12 EDP45041.1 - 1.3 7.4 14.0 0.2 10.2 9.7 1.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family FlgN PF05130.12 EDP45041.1 - 2.6 8.5 14.9 0.35 11.4 5.5 3.0 2 1 1 3 3 3 0 FlgN protein PRP38 PF03371.15 EDP45042.1 - 5.8e-62 208.6 0.1 7.4e-62 208.3 0.1 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.7 EDP45042.1 - 5.2e-07 30.2 13.4 9.6e-07 29.3 13.4 1.5 1 1 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term AA_permease PF00324.21 EDP45043.1 - 1.2e-61 208.8 29.6 1.5e-61 208.5 29.6 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EDP45043.1 - 8.8e-17 61.2 3.4 3.2e-10 39.6 0.0 3.9 4 0 0 4 4 4 3 Solute carrier family 12 Myosin_head PF00063.21 EDP45044.1 - 8.6e-253 840.5 0.0 1.3e-252 840.0 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 EDP45044.1 - 9e-28 96.6 1.7 9e-28 96.6 1.7 2.6 2 0 0 2 2 1 1 DIL domain AAA_22 PF13401.6 EDP45044.1 - 0.00034 20.9 0.3 0.0065 16.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain IQ PF00612.27 EDP45044.1 - 0.0006 19.4 43.4 0.038 13.8 1.2 7.3 7 0 0 7 7 7 4 IQ calmodulin-binding motif CENP-F_leu_zip PF10473.9 EDP45044.1 - 0.02 14.9 16.9 0.09 12.8 16.9 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EDP45044.1 - 0.023 14.9 6.7 0.034 14.4 4.9 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RNA_helicase PF00910.22 EDP45044.1 - 0.053 13.9 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EDP45044.1 - 0.17 12.2 0.0 0.17 12.2 0.0 3.4 2 1 0 2 2 1 0 AAA ATPase domain BST2 PF16716.5 EDP45044.1 - 0.2 12.2 22.6 0.073 13.7 6.1 4.2 2 1 2 4 4 3 0 Bone marrow stromal antigen 2 Myosin_N PF02736.19 EDP45044.1 - 0.21 11.4 0.5 0.59 10.0 0.4 1.8 1 1 0 1 1 1 0 Myosin N-terminal SH3-like domain Phage_GP20 PF06810.11 EDP45044.1 - 0.5 10.2 6.4 0.71 9.7 0.5 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 Fzo_mitofusin PF04799.13 EDP45044.1 - 0.82 9.2 13.1 0.062 12.9 4.2 2.6 1 1 1 2 2 2 0 fzo-like conserved region DivIC PF04977.15 EDP45044.1 - 0.97 9.3 21.8 0.41 10.4 2.5 4.2 3 1 1 4 4 4 0 Septum formation initiator Csm1_N PF18504.1 EDP45044.1 - 1.2 9.5 13.2 2.5 8.5 1.8 3.5 2 1 1 3 3 3 0 Csm1 N-terminal domain FapA PF03961.13 EDP45044.1 - 3.1 6.3 8.6 0.69 8.5 4.9 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A Laminin_II PF06009.12 EDP45044.1 - 3.6 7.6 11.2 3.7 7.6 5.4 2.4 1 1 1 2 2 2 0 Laminin Domain II V_ATPase_I PF01496.19 EDP45044.1 - 5 4.9 7.0 1.9 6.3 4.2 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Prefoldin PF02996.17 EDP45044.1 - 6.2 6.8 7.6 7.8 6.4 0.4 3.2 2 1 1 3 3 3 0 Prefoldin subunit UPF0242 PF06785.11 EDP45044.1 - 6.5 6.8 14.9 16 5.5 14.9 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc24 PF08286.11 EDP45044.1 - 8.4 6.7 12.8 6 7.2 2.6 2.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Syntaxin-6_N PF09177.11 EDP45044.1 - 8.9 6.9 10.5 1.8e+02 2.8 10.5 2.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TPR_19 PF14559.6 EDP45045.1 - 0.001 19.6 0.6 0.14 12.7 0.2 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF4205 PF13898.6 EDP45045.1 - 0.01 14.8 0.3 0.015 14.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) TPR_14 PF13428.6 EDP45045.1 - 0.011 16.5 0.1 7 7.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF410 PF04190.13 EDP45045.1 - 0.022 14.6 1.2 0.055 13.3 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF410) TPR_21 PF09976.9 EDP45045.1 - 0.028 14.1 0.4 0.047 13.4 0.4 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EDP45045.1 - 0.033 14.5 0.0 0.51 10.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat FUN14 PF04930.15 EDP45046.1 - 7.9e-20 71.1 0.1 1.3e-19 70.4 0.1 1.4 1 0 0 1 1 1 1 FUN14 family UPF0029 PF01205.19 EDP45047.1 - 1.6e-18 66.9 0.0 3.3e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Fungal_trans PF04082.18 EDP45048.1 - 5.2e-10 38.8 0.2 9e-10 38.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phytoreo_Pns PF05451.11 EDP45048.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 PHF5 PF03660.14 EDP45049.1 - 2.1e-14 53.6 0.2 2.3e-14 53.4 0.2 1.0 1 0 0 1 1 1 1 PHF5-like protein Pkinase PF00069.25 EDP45050.1 - 1.2e-58 198.5 0.0 7.4e-34 117.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45050.1 - 2e-20 73.2 0.0 1.1e-18 67.5 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EDP45050.1 - 0.00076 18.9 0.4 0.0015 18.0 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EDP45050.1 - 0.0021 18.0 0.7 0.0021 18.0 0.7 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EDP45050.1 - 0.0038 16.2 0.1 0.0053 15.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EDP45050.1 - 0.0047 16.3 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EDP45050.1 - 0.013 15.1 0.1 0.024 14.2 0.1 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EDP45050.1 - 0.082 12.5 1.4 0.33 10.5 0.0 2.2 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Tropomyosin_1 PF12718.7 EDP45051.1 - 1e-48 165.1 32.4 1.2e-48 164.9 32.4 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EDP45051.1 - 3.1e-11 43.1 32.3 0.00022 20.7 9.5 3.0 1 1 2 3 3 3 3 Tropomyosin GAS PF13851.6 EDP45051.1 - 0.00024 20.5 29.4 0.01 15.2 13.9 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding KELK PF15796.5 EDP45051.1 - 0.00033 21.0 6.4 0.00033 21.0 6.4 3.6 1 1 2 3 3 3 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Csm1_N PF18504.1 EDP45051.1 - 0.0035 17.6 29.5 1.3 9.4 3.6 3.9 1 1 2 3 3 3 2 Csm1 N-terminal domain FliJ PF02050.16 EDP45051.1 - 0.0054 17.0 16.8 0.0054 17.0 16.8 2.2 1 1 1 2 2 2 1 Flagellar FliJ protein TPR_MLP1_2 PF07926.12 EDP45051.1 - 0.0057 16.7 35.7 0.031 14.3 19.3 3.1 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein FH2 PF02181.23 EDP45051.1 - 0.013 14.7 4.8 0.013 14.7 4.8 2.0 1 1 1 2 2 2 0 Formin Homology 2 Domain FliD_C PF07195.12 EDP45051.1 - 0.013 14.9 17.0 0.088 12.2 8.9 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Tup_N PF08581.10 EDP45051.1 - 0.014 15.7 4.4 0.014 15.7 4.4 2.7 1 1 2 3 3 2 0 Tup N-terminal CENP-F_leu_zip PF10473.9 EDP45051.1 - 0.022 14.8 32.5 0.37 10.8 9.7 3.0 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CCDC-167 PF15188.6 EDP45051.1 - 0.031 14.6 9.1 0.031 14.6 9.1 3.4 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 DHR10 PF18595.1 EDP45051.1 - 0.035 14.2 38.1 0.28 11.2 11.9 2.7 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain HrpB7 PF09486.10 EDP45051.1 - 0.036 14.5 23.0 0.5 10.7 4.4 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) HOOK PF05622.12 EDP45051.1 - 0.043 12.0 25.8 0.062 11.4 25.8 1.3 1 0 0 1 1 1 0 HOOK protein DUF3450 PF11932.8 EDP45051.1 - 0.055 12.8 29.8 0.21 10.9 16.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BORCS7 PF16088.5 EDP45051.1 - 0.057 13.7 8.2 0.27 11.5 1.7 2.9 1 1 3 4 4 4 0 BLOC-1-related complex sub-unit 7 Rab5-bind PF09311.11 EDP45051.1 - 0.065 12.6 27.9 0.047 13.1 15.2 2.1 1 1 1 2 2 2 0 Rabaptin-like protein Lebercilin PF15619.6 EDP45051.1 - 0.071 12.8 34.0 0.042 13.5 17.3 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.8 EDP45051.1 - 0.16 12.0 34.5 0.16 12.0 13.1 3.4 2 2 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Alanine_zipper PF11839.8 EDP45051.1 - 0.16 12.3 15.7 1.5 9.2 3.4 3.7 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein DUF4200 PF13863.6 EDP45051.1 - 0.19 12.1 31.8 1.3 9.4 15.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 EDP45051.1 - 0.2 11.0 21.2 0.28 10.5 21.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Filament PF00038.21 EDP45051.1 - 0.24 10.9 29.1 0.053 13.1 14.6 2.1 1 1 1 2 2 2 0 Intermediate filament protein DUF5320 PF17253.2 EDP45051.1 - 0.26 12.4 0.5 0.26 12.4 0.5 3.3 3 2 0 3 3 2 0 Family of unknown function (DUF5320) Fmp27_WPPW PF10359.9 EDP45051.1 - 0.26 10.1 25.6 0.28 10.0 11.5 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain BRE1 PF08647.11 EDP45051.1 - 0.26 11.4 25.0 4.7 7.3 14.8 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase ADIP PF11559.8 EDP45051.1 - 0.31 11.1 29.8 3.5 7.7 8.5 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ERM PF00769.19 EDP45051.1 - 0.38 10.5 37.7 0.12 12.2 16.8 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family XhlA PF10779.9 EDP45051.1 - 0.45 10.8 25.1 0.42 10.8 2.1 4.1 2 2 1 3 3 3 0 Haemolysin XhlA T3SSipB PF16535.5 EDP45051.1 - 0.48 10.9 19.4 4.6 7.7 6.8 2.6 1 1 1 2 2 2 0 Type III cell invasion protein SipB CLZ PF16526.5 EDP45051.1 - 0.51 10.7 27.2 2.3 8.7 5.3 3.4 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin PF02996.17 EDP45051.1 - 0.58 10.1 23.1 0.17 11.8 3.6 3.8 1 1 3 4 4 4 0 Prefoldin subunit HMMR_N PF15905.5 EDP45051.1 - 0.6 9.5 28.6 0.94 8.9 28.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Fez1 PF06818.15 EDP45051.1 - 0.9 10.0 28.8 0.49 10.8 23.0 1.9 1 1 1 2 2 2 0 Fez1 DASH_Hsk3 PF08227.11 EDP45051.1 - 0.99 9.8 9.6 3.5 8.1 3.0 2.8 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like DUF641 PF04859.12 EDP45051.1 - 1.1 9.6 20.8 0.33 11.3 5.0 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ATG16 PF08614.11 EDP45051.1 - 1.1 9.4 35.3 20 5.4 35.3 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EDP45051.1 - 1.2 8.0 33.0 1.5 7.7 14.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Uso1_p115_C PF04871.13 EDP45051.1 - 1.2 9.5 35.0 0.41 11.0 14.7 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region NBP1 PF08537.10 EDP45051.1 - 1.4 8.3 19.3 1.1 8.6 6.4 2.6 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 DUF948 PF06103.11 EDP45051.1 - 1.4 9.2 7.4 1.5 9.1 2.0 2.9 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 EDP45051.1 - 1.8 9.1 42.1 1.2 9.6 26.1 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4472 PF14739.6 EDP45051.1 - 2 9.2 26.4 5.8 7.7 11.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4472) OEP PF02321.18 EDP45051.1 - 2.1 8.1 24.8 0.81 9.5 10.9 2.7 2 1 0 2 2 2 0 Outer membrane efflux protein DUF1664 PF07889.12 EDP45051.1 - 2.1 8.4 15.5 0.22 11.5 3.6 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Swi5 PF07061.11 EDP45051.1 - 2.1 8.5 24.7 0.21 11.7 2.6 3.9 1 1 3 4 4 4 0 Swi5 Prefoldin_2 PF01920.20 EDP45051.1 - 2.1 8.3 30.0 2.5 8.1 2.3 3.7 1 1 2 3 3 3 0 Prefoldin subunit LMBR1 PF04791.16 EDP45051.1 - 2.5 6.9 14.5 2.9 6.7 14.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NPV_P10 PF05531.12 EDP45051.1 - 2.5 8.6 7.8 13 6.3 2.2 3.1 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ApoO PF09769.9 EDP45051.1 - 2.7 8.0 6.9 14 5.6 1.2 3.0 1 1 2 3 3 3 0 Apolipoprotein O Fib_alpha PF08702.10 EDP45051.1 - 2.8 8.1 17.7 3.7 7.7 7.6 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 EDP45051.1 - 3.3 7.9 36.1 1.5 9.0 16.1 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.8 EDP45051.1 - 3.3 5.1 32.1 0.17 9.4 15.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) IZUMO PF15005.6 EDP45051.1 - 3.8 8.0 7.5 4.1 7.9 6.1 1.8 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF812 PF05667.11 EDP45051.1 - 4.1 6.2 27.7 2.6 6.8 7.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) AAA_13 PF13166.6 EDP45051.1 - 4.1 5.9 22.4 6.4 5.3 22.4 1.3 1 1 0 1 1 1 0 AAA domain Cob_adeno_trans PF01923.18 EDP45051.1 - 4.7 7.3 9.1 1.4 9.0 4.5 1.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF724 PF05266.14 EDP45051.1 - 4.7 7.0 27.5 5.4 6.8 8.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CHDCT2 PF08074.11 EDP45051.1 - 5.1 7.2 12.9 0.68 10.1 5.7 2.0 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain Atg14 PF10186.9 EDP45051.1 - 5.2 6.1 27.9 0.58 9.2 8.2 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF745 PF05335.13 EDP45051.1 - 6.3 6.5 24.0 0.66 9.7 8.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF745) FAP206 PF12018.8 EDP45051.1 - 6.5 6.2 17.4 8 5.9 6.4 2.7 1 1 0 2 2 2 0 Domain of unknown function NuiA PF07924.11 EDP45051.1 - 6.9 7.1 10.9 3 8.2 4.1 2.2 1 1 1 2 2 2 0 Nuclease A inhibitor-like protein PI3K_P85_iSH2 PF16454.5 EDP45051.1 - 8.5 6.0 27.1 9.5 5.8 5.6 2.9 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_TATA_bd PF12325.8 EDP45051.1 - 9.7 6.5 32.4 0.15 12.3 11.4 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding UQ_con PF00179.26 EDP45052.1 - 5.4e-46 155.7 0.0 6.1e-46 155.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EDP45052.1 - 0.015 15.6 0.2 0.025 14.8 0.2 1.6 1 1 0 1 1 1 0 RWD domain Glyco_transf_21 PF13506.6 EDP45053.1 - 7.2e-22 77.7 1.0 1.5e-14 53.9 0.2 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EDP45053.1 - 2.2e-10 40.8 0.5 2.2e-09 37.5 0.5 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EDP45053.1 - 0.00032 20.6 0.0 0.00062 19.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 2 FGGY_C PF02782.16 EDP45054.1 - 1.3e-37 129.5 0.2 1.9e-37 129.0 0.2 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EDP45054.1 - 4.3e-07 29.8 0.0 8.6e-05 22.2 0.0 2.6 3 0 0 3 3 3 2 FGGY family of carbohydrate kinases, N-terminal domain ADH_N PF08240.12 EDP45055.1 - 3.8e-25 87.9 0.5 7.3e-25 87.0 0.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EDP45055.1 - 5.8e-21 74.8 0.1 1.1e-20 73.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EDP45055.1 - 0.017 14.4 0.3 0.029 13.7 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Arrestin_N PF00339.29 EDP45056.1 - 1.8e-06 28.1 0.0 1.3e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Nas2_N PF18265.1 EDP45057.1 - 4.2e-22 77.9 1.0 9.1e-22 76.8 1.0 1.6 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 EDP45057.1 - 4.3e-09 36.6 0.0 8.4e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EDP45057.1 - 2.9e-08 33.4 0.0 9.3e-08 31.8 0.0 1.9 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.14 EDP45057.1 - 0.00025 21.4 0.0 0.00055 20.3 0.0 1.6 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 EDP45057.1 - 0.021 15.2 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 PDZ domain TatC PF00902.18 EDP45058.1 - 0.0054 16.6 5.0 0.0067 16.3 5.0 1.2 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) Utp11 PF03998.13 EDP45059.1 - 1.4e-59 202.1 27.3 1.8e-59 201.6 27.3 1.2 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 EDP45059.1 - 0.018 14.4 0.2 0.24 10.7 0.5 2.2 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MFS_1 PF07690.16 EDP45060.1 - 3.1e-25 88.8 37.9 4.8e-24 84.9 37.0 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily ATG22 PF11700.8 EDP45060.1 - 0.0082 14.8 7.6 0.18 10.4 0.2 2.5 2 0 0 2 2 2 2 Vacuole effluxer Atg22 like Pkinase PF00069.25 EDP45061.1 - 5.9e-17 61.9 0.0 7.2e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45061.1 - 2.6e-10 40.0 0.0 3.5e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP45061.1 - 1.4e-09 37.2 0.0 1.9e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EDP45061.1 - 0.0031 17.5 0.1 0.0074 16.2 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP45061.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EDP45061.1 - 0.19 10.6 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ion_trans PF00520.31 EDP45062.1 - 7.4e-05 22.1 7.0 9.8e-05 21.7 7.0 1.2 1 0 0 1 1 1 1 Ion transport protein CitMHS PF03600.16 EDP45062.1 - 0.013 14.7 0.5 0.016 14.5 0.5 1.1 1 0 0 1 1 1 0 Citrate transporter ACT_5 PF13710.6 EDP45062.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 ACT domain Hydrolase_6 PF13344.6 EDP45063.1 - 1.6e-28 98.8 0.0 3.1e-28 97.9 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EDP45063.1 - 2.1e-20 72.5 0.0 4.9e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EDP45063.1 - 3e-08 34.2 0.0 2.5e-07 31.2 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EDP45063.1 - 2.1e-07 31.2 0.0 4.4e-05 23.6 0.0 2.3 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EDP45063.1 - 0.023 14.3 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) PGP_phosphatase PF09419.10 EDP45063.1 - 0.12 11.9 0.0 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase BPL_LplA_LipB PF03099.19 EDP45064.1 - 2.1e-14 53.6 0.0 3.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_N PF09825.9 EDP45064.1 - 0.0012 18.1 0.0 0.0014 17.8 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal Cullin PF00888.22 EDP45065.1 - 2.2e-90 304.1 0.0 5e-90 302.9 0.0 1.5 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EDP45065.1 - 8.7e-16 57.7 0.2 3.7e-15 55.7 0.1 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF908 PF06012.12 EDP45066.1 - 6.6e-76 256.0 0.1 1.2e-75 255.2 0.1 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 EDP45066.1 - 5.8e-71 239.4 0.3 6e-70 236.1 0.2 2.7 2 1 0 2 2 2 1 Domain of Unknown Function (DUF913) UBA PF00627.31 EDP45066.1 - 4.9e-10 39.1 0.2 1.7e-09 37.4 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain TH1 PF04858.13 EDP45066.1 - 0.019 13.7 0.1 0.03 13.0 0.1 1.2 1 0 0 1 1 1 0 TH1 protein DUF3361 PF11841.8 EDP45066.1 - 0.11 12.5 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) UBM PF14377.6 EDP45067.1 - 1.1e-08 34.3 7.4 2.6e-08 33.0 1.1 3.4 3 0 0 3 3 3 2 Ubiquitin binding region HOOK PF05622.12 EDP45068.1 - 0.0004 18.7 15.5 0.0004 18.7 15.5 3.6 1 1 1 4 4 4 2 HOOK protein Laminin_II PF06009.12 EDP45068.1 - 0.013 15.5 1.1 0.013 15.5 1.1 3.7 2 1 1 4 4 4 0 Laminin Domain II YabA PF06156.13 EDP45068.1 - 0.18 12.4 23.6 0.94 10.1 1.5 4.6 1 1 3 4 4 4 0 Initiation control protein YabA Get5_C PF18514.1 EDP45068.1 - 0.36 10.6 3.8 0.86 9.4 0.0 3.2 3 0 0 3 3 3 0 Get5 C-terminal domain BLOC1_2 PF10046.9 EDP45068.1 - 0.44 10.9 21.0 1.7 9.0 4.4 4.2 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TssO PF17561.2 EDP45068.1 - 1.1 9.3 7.7 1.3 9.1 0.4 3.3 2 1 0 2 2 2 0 Type VI secretion system, TssO COG2 PF06148.11 EDP45068.1 - 1.4 9.0 14.2 0.38 10.8 1.1 3.8 2 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ATG16 PF08614.11 EDP45068.1 - 1.8 8.7 43.0 4.3 7.5 21.0 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 EDP45068.1 - 2 9.0 0.0 2 9.0 0.0 4.0 5 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein Jnk-SapK_ap_N PF09744.9 EDP45068.1 - 2 8.6 41.8 0.4 10.9 7.0 4.2 1 1 2 4 4 4 0 JNK_SAPK-associated protein-1 HSP70 PF00012.20 EDP45069.1 - 2.3e-259 861.6 6.6 2.7e-259 861.4 6.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EDP45069.1 - 6.5e-15 54.8 0.1 2.3e-13 49.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EDP45069.1 - 0.0038 17.6 0.3 15 6.1 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.18 EDP45069.1 - 0.052 12.8 0.1 0.14 11.3 0.1 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase zf-C3HC4 PF00097.25 EDP45070.1 - 0.001 18.9 2.6 0.0018 18.1 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDP45070.1 - 0.019 15.0 0.6 0.019 15.0 0.6 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EDP45070.1 - 0.025 14.9 3.1 0.047 14.0 3.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 EDP45070.1 - 0.042 13.7 0.9 0.064 13.1 0.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EDP45070.1 - 0.15 11.9 3.7 0.33 10.9 3.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EDP45070.1 - 0.17 12.1 2.4 0.27 11.4 2.4 1.3 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EDP45070.1 - 0.49 10.6 2.9 1 9.6 2.9 1.6 1 0 0 1 1 1 0 RING-variant domain zf-rbx1 PF12678.7 EDP45070.1 - 0.58 10.5 10.1 0.082 13.2 3.6 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain TFIIF_beta PF02270.15 EDP45071.1 - 2.2e-26 91.8 0.2 4.2e-26 90.9 0.2 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EDP45071.1 - 1.7e-22 80.6 0.0 3.3e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus DDE_Tnp_IS66_C PF13817.6 EDP45071.1 - 0.027 14.7 0.0 0.089 13.0 0.0 1.9 1 0 0 1 1 1 0 IS66 C-terminal element Aminotran_5 PF00266.19 EDP45072.1 - 4.1e-35 121.4 0.0 5.4e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Mcl1_mid PF12341.8 EDP45073.1 - 8.4e-73 245.3 0.0 1.8e-72 244.2 0.0 1.5 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EDP45073.1 - 0.00012 22.7 0.0 0.014 16.2 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45073.1 - 0.00067 19.9 0.0 0.005 17.1 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EDP45073.1 - 0.17 11.6 0.0 0.47 10.2 0.0 1.7 1 0 0 1 1 1 0 TUP1-like enhancer of split Glyco_hydro_cc PF11790.8 EDP45074.1 - 7.4e-58 195.9 6.6 9.8e-58 195.5 6.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Spt20 PF12090.8 EDP45075.1 - 6.2e-24 84.9 6.7 7.6e-12 45.3 0.0 3.4 3 1 0 3 3 3 2 Spt20 family Glycolipid_bind PF06475.11 EDP45075.1 - 0.016 14.8 0.1 0.037 13.5 0.0 1.6 1 1 0 1 1 1 0 Putative glycolipid-binding PINIT PF14324.6 EDP45076.1 - 7.2e-30 104.3 0.0 1.3e-29 103.4 0.0 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EDP45076.1 - 2.3e-21 75.3 6.7 4.7e-21 74.3 6.7 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EDP45076.1 - 2.7e-08 33.5 2.1 5.4e-08 32.5 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EDP45076.1 - 0.0064 16.2 0.1 1.2 9.0 0.0 2.7 2 0 0 2 2 2 2 SAP domain TNT PF14021.6 EDP45076.1 - 0.02 15.4 0.2 0.077 13.6 0.0 2.0 2 0 0 2 2 2 0 Tuberculosis necrotizing toxin Rad50_zn_hook PF04423.14 EDP45076.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif MgsA_C PF12002.8 EDP45077.1 - 3.5e-35 121.4 0.1 6.3e-35 120.6 0.1 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EDP45077.1 - 1.5e-21 76.5 3.6 3e-21 75.5 1.6 2.4 2 0 0 2 2 2 1 AAA C-terminal domain AAA PF00004.29 EDP45077.1 - 3e-13 50.3 0.1 5.2e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EDP45077.1 - 1e-11 44.9 0.1 3.2e-11 43.2 0.1 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EDP45077.1 - 6.6e-09 36.4 7.0 0.0002 21.8 0.0 3.3 1 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EDP45077.1 - 3.5e-08 33.8 1.1 8.8e-06 26.0 1.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EDP45077.1 - 1.2e-07 31.8 0.1 2.2e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EDP45077.1 - 1.5e-07 31.5 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EDP45077.1 - 2.2e-05 24.0 0.6 0.046 13.1 0.1 2.6 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EDP45077.1 - 5.2e-05 23.6 1.4 0.018 15.4 0.2 2.6 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EDP45077.1 - 0.00011 22.0 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 EDP45077.1 - 0.00012 22.3 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 EDP45077.1 - 0.00014 22.0 0.0 0.00028 21.0 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EDP45077.1 - 0.00015 21.6 0.0 0.00042 20.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EDP45077.1 - 0.00033 20.5 0.0 0.00084 19.1 0.0 1.8 2 0 0 2 2 1 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EDP45077.1 - 0.00034 20.4 0.0 0.00069 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP45077.1 - 0.00037 21.0 0.0 0.00088 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EDP45077.1 - 0.00037 20.2 0.1 0.29 10.8 0.1 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 EDP45077.1 - 0.00048 19.7 0.0 0.00077 19.0 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 EDP45077.1 - 0.0011 18.2 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EDP45077.1 - 0.0015 19.1 0.0 0.0027 18.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 EDP45077.1 - 0.0024 18.2 0.0 0.0059 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EDP45077.1 - 0.0042 16.3 0.0 0.0092 15.2 0.0 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 EDP45077.1 - 0.0045 17.2 1.9 0.013 15.7 0.4 2.4 1 1 0 2 2 2 1 AAA domain TniB PF05621.11 EDP45077.1 - 0.0056 16.1 0.3 1.8 7.9 0.0 2.3 1 1 1 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 EDP45077.1 - 0.0071 16.3 0.2 0.036 14.0 0.2 2.2 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 EDP45077.1 - 0.012 15.6 0.1 1.4 8.8 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EDP45077.1 - 0.021 15.2 0.0 0.048 14.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EDP45077.1 - 0.03 13.9 2.0 0.072 12.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EDP45077.1 - 0.088 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase TIP49 PF06068.13 EDP45077.1 - 0.11 11.6 0.0 0.32 10.2 0.0 1.5 1 1 1 2 2 2 0 TIP49 P-loop domain Deltameth_res PF16020.5 EDP45077.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Deltamethrin resistance SRPRB PF09439.10 EDP45077.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.19 EDP45077.1 - 0.16 11.5 0.1 0.33 10.5 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EDP45077.1 - 0.21 11.5 0.4 3.2 7.6 0.0 2.2 1 1 1 2 2 2 0 NTPase DUF4880 PF16220.5 EDP45077.1 - 0.46 10.4 4.8 19 5.2 1.1 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF4880) DUF543 PF04418.12 EDP45078.1 - 2.3e-29 101.2 0.1 4.4e-29 100.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Gp-FAR-1 PF05823.12 EDP45078.1 - 0.045 14.1 0.3 0.11 12.9 0.3 1.6 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) YtxH PF12732.7 EDP45078.1 - 0.061 13.9 6.2 0.27 11.8 1.9 3.0 2 1 0 2 2 2 0 YtxH-like protein DUF883 PF05957.13 EDP45078.1 - 0.075 13.7 2.3 1.8 9.2 1.1 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ndc1_Nup PF09531.10 EDP45078.1 - 0.2 10.3 0.4 0.71 8.5 0.0 1.8 1 1 1 2 2 2 0 Nucleoporin protein Ndc1-Nup zf-CpG_bind_C PF12269.8 EDP45079.1 - 6.8e-06 26.0 1.6 1.7e-05 24.7 0.2 2.0 2 1 0 2 2 2 1 CpG binding protein zinc finger C terminal domain Pkinase PF00069.25 EDP45080.1 - 2.3e-05 23.9 0.0 2.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 EDP45081.1 - 7e-27 94.4 0.0 2.5e-22 79.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45081.1 - 2.1e-11 43.6 0.0 9.6e-11 41.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EDP45081.1 - 0.0099 15.5 0.0 0.039 13.5 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EDP45081.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EDP45081.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PEX11 PF05648.14 EDP45082.1 - 0.00017 21.1 0.1 0.00029 20.4 0.1 1.5 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Ribosomal_S17 PF00366.20 EDP45083.1 - 2.2e-20 72.5 0.5 3.1e-20 72.0 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 Zds_C PF08632.10 EDP45084.1 - 9.7e-24 82.9 0.9 2.1e-23 81.8 0.9 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Smr PF01713.21 EDP45085.1 - 1.1e-11 44.8 1.0 3.6e-11 43.2 0.1 2.4 3 0 0 3 3 3 1 Smr domain CUE PF02845.16 EDP45085.1 - 3.3e-06 26.7 0.7 0.00071 19.2 0.1 2.9 3 0 0 3 3 3 2 CUE domain DUF1771 PF08590.10 EDP45085.1 - 0.00011 22.6 6.1 0.00011 22.6 6.1 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) MFS_1 PF07690.16 EDP45086.1 - 2.6e-22 79.2 24.9 2.6e-22 79.2 24.9 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP45086.1 - 4.6e-22 78.5 9.5 1.3e-17 63.9 0.6 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter TMEM213 PF15192.6 EDP45086.1 - 0.092 12.7 0.1 0.33 10.9 0.1 2.0 1 0 0 1 1 1 0 TMEM213 family Urb2 PF10441.9 EDP45087.1 - 1.5e-46 158.9 0.0 1.5e-46 158.9 0.0 2.8 2 1 1 3 3 3 1 Urb2/Npa2 family SIP1 PF04938.12 EDP45087.1 - 0.037 13.7 1.3 0.1 12.3 0.2 2.4 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) NOD PF06816.13 EDP45087.1 - 1.6 8.4 4.3 55 3.5 0.0 4.3 5 0 0 5 5 5 0 NOTCH protein Ribosomal_L36 PF00444.18 EDP45089.1 - 1.4e-21 76.4 9.3 1.5e-21 76.3 9.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36 NTP_transferase PF00483.23 EDP45090.1 - 4.2e-39 134.6 0.0 6e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 EDP45090.1 - 2.7e-06 27.4 0.2 4.7e-06 26.6 0.2 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase NIR_SIR PF01077.22 EDP45091.1 - 1.9e-45 154.2 0.0 1.3e-39 135.3 0.0 2.3 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.25 EDP45091.1 - 3.9e-28 98.5 0.1 9.9e-28 97.1 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin NIR_SIR_ferr PF03460.17 EDP45091.1 - 1.2e-25 89.1 0.0 1.9e-11 43.6 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain POR_N PF01855.19 EDP45091.1 - 6.3e-06 26.1 0.4 1.3e-05 25.1 0.4 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg RNB PF00773.19 EDP45092.1 - 1.7e-93 313.6 0.1 2.2e-93 313.2 0.1 1.1 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EDP45092.1 - 3.3e-21 75.5 0.0 7.3e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EDP45092.1 - 4.8e-20 71.3 0.0 9.6e-20 70.3 0.0 1.5 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EDP45092.1 - 5.8e-16 58.3 0.0 1.4e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EDP45092.1 - 1.9e-11 44.4 0.1 4.7e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EDP45092.1 - 3e-07 30.5 0.0 2e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 Cold shock domain DUF3379 PF11859.8 EDP45092.1 - 0.037 13.3 0.0 0.11 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3379) NDK PF00334.19 EDP45093.1 - 5.3e-51 172.2 0.0 6.5e-51 171.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase TAFII55_N PF04658.13 EDP45094.1 - 6e-54 182.1 2.2 7.6e-54 181.8 0.0 2.2 2 0 0 2 2 2 1 TAFII55 protein conserved region Pox_F11 PF04943.12 EDP45094.1 - 2.4 7.1 4.8 4.1 6.4 4.8 1.3 1 0 0 1 1 1 0 Poxvirus F11 protein DUF1741 PF08427.10 EDP45095.1 - 1.1e-18 67.8 1.5 1.1e-18 67.8 1.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1741) Cation_efflux PF01545.21 EDP45096.1 - 6.9e-45 153.2 21.7 1.6e-44 152.0 21.7 1.6 1 1 0 1 1 1 1 Cation efflux family Atg14 PF10186.9 EDP45096.1 - 0.23 10.5 3.6 0.38 9.8 3.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RAI1 PF08652.11 EDP45097.1 - 1e-20 73.7 0.0 2e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease GTP_EFTU PF00009.27 EDP45098.1 - 7.2e-53 179.0 0.0 1.1e-52 178.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EDP45098.1 - 1e-42 144.9 0.0 2e-42 144.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EDP45098.1 - 1.4e-14 54.2 0.7 4.2e-14 52.7 0.7 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EDP45098.1 - 0.00075 19.6 0.1 0.018 15.1 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EDP45098.1 - 0.026 14.4 0.5 0.086 12.8 0.5 1.9 1 0 0 1 1 1 0 Elongation factor Tu domain 4 NIF3 PF01784.18 EDP45098.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) 5HT_transport_N PF03491.13 EDP45098.1 - 0.043 14.0 1.5 0.065 13.4 0.0 2.1 2 0 0 2 2 2 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus G-alpha PF00503.20 EDP45098.1 - 0.18 10.9 0.1 0.35 10.0 0.0 1.5 2 0 0 2 2 2 0 G-protein alpha subunit WH1 PF00568.23 EDP45099.1 - 5.5e-20 71.4 0.0 8.1e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EDP45099.1 - 0.0053 16.6 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 WH2 motif DCP1 PF06058.13 EDP45099.1 - 0.0092 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family UQ_con PF00179.26 EDP45100.1 - 1.4e-36 125.2 0.0 1.7e-36 125.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDP45100.1 - 4.8e-05 23.1 0.0 6.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EDP45100.1 - 0.0073 16.2 0.1 0.015 15.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EDP45100.1 - 0.052 13.8 0.2 0.08 13.2 0.1 1.4 1 1 0 1 1 1 0 RWD domain DUF2841 PF11001.8 EDP45101.1 - 2.7e-39 134.1 0.6 4.7e-39 133.3 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) GATA PF00320.27 EDP45102.1 - 5.5e-26 89.9 22.3 6.8e-14 51.2 5.7 2.7 3 0 0 3 3 3 2 GATA zinc finger DZR PF12773.7 EDP45102.1 - 0.00015 21.8 3.3 0.0022 18.0 3.9 2.6 1 1 1 2 2 2 2 Double zinc ribbon Zn-ribbon_8 PF09723.10 EDP45102.1 - 0.0023 18.0 0.4 2.8 8.1 0.0 3.0 2 0 0 2 2 2 2 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 EDP45102.1 - 0.0043 16.9 3.5 0.055 13.3 0.3 2.3 2 0 0 2 2 2 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 EDP45102.1 - 0.0073 15.8 6.4 0.035 13.6 0.1 3.2 2 1 0 2 2 2 1 TFIIB zinc-binding zinc_ribbon_15 PF17032.5 EDP45102.1 - 0.051 14.3 4.0 2.7 8.8 4.1 2.9 1 1 2 3 3 3 0 zinc-ribbon family DUF3268 PF11672.8 EDP45102.1 - 0.087 13.2 1.4 2.3 8.5 0.1 2.5 2 0 0 2 2 2 0 zinc-finger-containing domain zf-ribbon_3 PF13248.6 EDP45102.1 - 0.17 11.3 10.1 1.1 8.7 0.2 4.3 4 0 0 4 4 4 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 EDP45102.1 - 0.42 10.8 5.5 9 6.6 0.5 2.7 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Vps36-NZF-N PF16988.5 EDP45102.1 - 0.5 9.8 9.9 2.4 7.6 0.5 4.3 2 1 2 4 4 4 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_2 PF13240.6 EDP45102.1 - 0.82 9.5 14.4 1.3 8.8 0.2 4.0 4 0 0 4 4 4 0 zinc-ribbon domain zf-B_box PF00643.24 EDP45102.1 - 4.8 7.4 9.1 2.5 8.3 1.6 3.6 3 1 0 3 3 3 0 B-box zinc finger Nudix_N_2 PF14803.6 EDP45102.1 - 8.1 6.5 8.8 35 4.4 0.2 3.9 3 1 0 3 3 3 0 Nudix N-terminal His_Phos_1 PF00300.22 EDP45103.1 - 2.7e-25 89.2 0.0 3.3e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PEMT PF04191.13 EDP45104.1 - 2.7e-55 185.3 5.7 1.1e-31 109.3 0.5 2.8 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 EDP45104.1 - 0.0086 15.9 0.0 0.032 14.0 0.0 1.8 1 1 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 EDP45104.1 - 0.041 14.4 0.0 2.7 8.6 0.0 2.5 2 0 0 2 2 2 0 SKICH domain DNA_pol_B PF00136.21 EDP45105.1 - 8.9e-87 291.7 0.0 1.4e-86 291.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EDP45105.1 - 7.5e-21 74.6 0.0 2.2e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EDP45105.1 - 5.3e-10 39.6 4.9 1.3e-09 38.3 4.9 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EDP45105.1 - 0.022 13.6 0.1 0.032 13.1 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Defensin_int PF17858.1 EDP45105.1 - 6.5 6.8 8.3 4.4 7.4 1.3 3.5 3 0 0 3 3 3 0 Platypus intermediate defensin-like peptide HEAT PF02985.22 EDP45106.1 - 1.3e-40 133.9 22.7 0.00014 21.8 0.0 13.4 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 EDP45106.1 - 6.7e-29 100.1 13.6 3.9e-09 36.8 0.0 7.4 3 2 5 8 8 8 7 HEAT repeats Vac14_Fab1_bd PF12755.7 EDP45106.1 - 6e-15 55.6 1.9 0.00019 22.0 0.0 7.0 4 2 4 8 8 8 4 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EDP45106.1 - 1.7e-11 44.4 8.8 0.026 14.6 0.1 4.9 3 1 2 5 5 5 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EDP45106.1 - 1.6e-10 41.2 17.6 0.026 15.0 0.0 9.2 8 3 3 11 11 11 3 HEAT-like repeat Adaptin_N PF01602.20 EDP45106.1 - 2.6e-07 29.6 9.4 0.00072 18.2 2.4 4.0 2 1 1 3 3 3 2 Adaptin N terminal region CLASP_N PF12348.8 EDP45106.1 - 4.7e-07 29.6 2.5 0.076 12.6 0.1 4.2 1 1 2 4 4 4 2 CLASP N terminal Arm PF00514.23 EDP45106.1 - 4.7e-06 26.4 2.0 0.25 11.5 0.0 6.6 6 1 0 7 7 7 1 Armadillo/beta-catenin-like repeat Tti2 PF10521.9 EDP45106.1 - 0.031 13.8 0.5 5.9 6.3 0.0 3.9 4 2 1 5 5 5 0 Tti2 family CRAL_TRIO PF00650.20 EDP45107.1 - 1.9e-38 131.7 0.0 2.4e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EDP45107.1 - 1.2e-06 28.7 0.0 1.7e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DSX_dimer PF08828.10 EDP45107.1 - 0.0025 17.4 0.1 0.0051 16.5 0.1 1.4 1 0 0 1 1 1 1 Doublesex dimerisation domain ESR1_C PF12743.7 EDP45107.1 - 0.23 11.3 1.4 6.8 6.6 0.2 2.4 2 0 0 2 2 2 0 Oestrogen-type nuclear receptor final C-terminal SURF4 PF02077.15 EDP45108.1 - 1.7e-70 237.7 7.8 1.8e-70 237.6 7.8 1.0 1 0 0 1 1 1 1 SURF4 family NAT PF04768.13 EDP45109.1 - 1.1e-38 132.5 0.0 1.6e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EDP45109.1 - 3.1e-22 79.3 0.0 1.4e-21 77.2 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 EDP45109.1 - 1.3e-07 31.9 0.0 2.3e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 EDP45109.1 - 0.071 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Retrotrans_gag PF03732.17 EDP45111.1 - 0.05 13.9 0.3 0.092 13.0 0.3 1.4 1 0 0 1 1 1 0 Retrotransposon gag protein DUF4569 PF15133.6 EDP45111.1 - 0.075 12.7 0.4 0.82 9.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4569) Pkinase PF00069.25 EDP45113.1 - 9e-47 159.6 0.0 1.1e-46 159.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45113.1 - 3.6e-32 111.7 0.0 4.5e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP45113.1 - 1.6e-08 33.8 0.0 2.2e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EDP45113.1 - 0.0043 16.4 0.7 0.0063 15.9 0.7 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Creatinase_N_2 PF16189.5 EDP45114.1 - 6e-50 169.5 0.0 5.6e-49 166.3 0.0 2.3 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EDP45114.1 - 1.4e-41 142.5 0.0 2.4e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EDP45114.1 - 1.9e-25 88.7 0.0 7.4e-25 86.8 0.0 2.1 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EDP45114.1 - 5e-25 88.7 0.0 3.8e-18 66.4 0.0 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain AdoHcyase PF05221.17 EDP45115.1 - 2.7e-135 450.3 0.0 3.4e-74 249.7 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EDP45115.1 - 7.7e-84 279.7 2.1 1.2e-83 279.1 2.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EDP45115.1 - 1.9e-10 40.4 0.4 7.3e-10 38.5 0.1 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EDP45115.1 - 0.00016 21.3 0.1 0.00025 20.6 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EDP45115.1 - 0.0025 18.1 0.0 0.0056 16.9 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 EDP45115.1 - 0.01 16.3 0.1 0.024 15.0 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EDP45115.1 - 0.016 15.3 0.2 0.033 14.3 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 EDP45115.1 - 0.021 14.5 0.2 0.038 13.7 0.2 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase EF-hand_1 PF00036.32 EDP45117.1 - 1e-25 87.3 9.8 3e-09 35.8 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EDP45117.1 - 1.7e-24 86.1 9.7 4e-12 46.4 4.7 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EDP45117.1 - 1.1e-20 71.7 7.0 6.2e-09 35.1 0.2 4.1 4 1 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EDP45117.1 - 7.8e-14 51.3 12.5 2.8e-05 23.9 0.3 4.7 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 EDP45117.1 - 3e-13 48.6 8.4 1.7e-05 24.1 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EDP45117.1 - 4.8e-10 39.6 0.6 6.1e-06 26.5 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EDP45117.1 - 1.1e-05 25.3 2.3 0.00015 21.7 0.0 2.5 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EDP45117.1 - 0.0013 18.7 0.7 0.056 13.4 0.0 2.8 3 0 0 3 3 3 1 Caleosin related protein SurA_N_2 PF13623.6 EDP45117.1 - 0.012 15.5 0.4 0.91 9.4 0.1 2.4 2 1 0 2 2 2 0 SurA N-terminal domain Dockerin_1 PF00404.18 EDP45117.1 - 0.035 14.3 0.1 1.1 9.5 0.0 2.4 2 1 0 2 2 2 0 Dockerin type I domain DUF4601 PF15373.6 EDP45117.1 - 0.15 11.0 0.0 0.91 8.4 0.0 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4601) EF-hand_14 PF17959.1 EDP45117.1 - 0.21 12.0 1.8 6.4 7.2 0.4 2.4 2 1 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 EDP45117.1 - 0.26 11.6 2.8 9.2 6.6 0.5 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TFIIA_gamma_N PF02268.16 EDP45118.1 - 7.9e-25 86.6 0.1 1.1e-24 86.2 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 EDP45118.1 - 2.8e-22 78.6 0.5 4.7e-22 77.9 0.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit GATA PF00320.27 EDP45119.1 - 2e-09 36.9 6.2 6.2e-06 25.7 1.4 2.7 2 0 0 2 2 2 2 GATA zinc finger OrfB_Zn_ribbon PF07282.11 EDP45119.1 - 0.58 10.1 4.2 8.8 6.3 4.2 2.5 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Ctf8 PF09696.10 EDP45120.1 - 1.7e-13 51.1 0.9 7e-11 42.6 0.9 2.9 1 1 0 1 1 1 1 Ctf8 GHMP_kinases_N PF00288.26 EDP45122.1 - 1.3e-11 44.6 1.5 2.9e-11 43.4 1.5 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EDP45122.1 - 2.5e-10 40.5 0.0 6.6e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal HTH_31 PF13560.6 EDP45122.1 - 0.047 14.0 0.5 19 5.7 0.4 2.9 2 0 0 2 2 2 0 Helix-turn-helix domain SANT_DAMP1_like PF16282.5 EDP45123.1 - 1e-30 105.7 2.9 1e-30 105.7 2.9 1.7 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 HCMV_UL139 PF12507.8 EDP45123.1 - 0.01 16.2 1.4 0.031 14.6 1.4 1.8 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein Myb_DNA-binding PF00249.31 EDP45123.1 - 0.058 13.6 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EDP45123.1 - 0.11 12.8 0.7 0.33 11.2 0.1 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain DFP PF04127.15 EDP45124.1 - 8.6e-19 68.1 0.0 2e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein zf-C2H2 PF00096.26 EDP45125.1 - 4.8e-09 36.2 12.6 7.7e-07 29.2 0.4 3.8 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EDP45125.1 - 1.1e-08 35.1 0.6 1.1e-08 35.1 0.6 4.6 5 0 0 5 5 5 1 Zinc-finger double domain FOXP-CC PF16159.5 EDP45125.1 - 8.5e-06 26.3 12.0 0.015 15.9 0.4 3.7 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EDP45125.1 - 0.0003 21.4 12.3 0.0089 16.8 0.3 3.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 EDP45125.1 - 0.0012 19.1 1.2 4.1 7.9 0.0 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type DUF3861 PF12977.7 EDP45125.1 - 0.026 14.7 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) zf-C2H2_6 PF13912.6 EDP45125.1 - 0.032 14.2 4.2 0.069 13.2 0.0 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf_ZIC PF18366.1 EDP45125.1 - 4.7 7.4 8.2 7.9 6.7 0.1 3.5 2 2 1 3 3 3 0 Zic proteins zinc finger domain Complex1_LYR PF05347.15 EDP45126.1 - 1.6e-10 40.9 0.7 2.2e-10 40.4 0.2 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EDP45126.1 - 0.00016 22.4 2.3 0.0005 20.8 2.3 1.6 1 1 0 1 1 1 1 Complex1_LYR-like adh_short_C2 PF13561.6 EDP45127.1 - 1.5e-37 129.4 0.0 2.2e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EDP45127.1 - 1.6e-31 109.3 0.0 3.4e-31 108.2 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase DnaJ PF00226.31 EDP45128.1 - 5.1e-18 65.0 5.4 5.1e-18 65.0 5.4 1.5 2 0 0 2 2 2 1 DnaJ domain Gly-zipper_YMGG PF13441.6 EDP45128.1 - 0.003 17.3 9.1 0.0047 16.6 9.1 1.2 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 EDP45128.1 - 0.017 14.9 6.7 0.027 14.3 6.7 1.3 1 0 0 1 1 1 0 Glycine-zipper domain Gly-zipper_Omp PF13488.6 EDP45128.1 - 0.022 14.8 8.7 0.033 14.2 8.7 1.3 1 0 0 1 1 1 0 Glycine zipper CoA_binding_3 PF13727.6 EDP45128.1 - 0.093 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 CoA-binding domain Rick_17kDa_Anti PF05433.15 EDP45128.1 - 0.11 12.3 13.0 0.28 11.1 1.2 2.2 1 1 1 2 2 2 0 Glycine zipper 2TM domain DUF4813 PF16072.5 EDP45128.1 - 0.14 11.8 1.0 0.21 11.2 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Bacteriocin_IIc PF10439.9 EDP45128.1 - 0.49 10.5 8.7 0.75 10.0 8.7 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide MMM1 PF10296.9 EDP45129.1 - 1.6e-41 142.4 0.0 4.4e-38 131.2 0.0 2.7 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 LIX1 PF14954.6 EDP45129.1 - 0.2 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Limb expression 1 SPRY PF00622.28 EDP45130.1 - 9e-06 25.8 0.0 9e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 SPRY domain SUI1 PF01253.22 EDP45131.1 - 5e-14 52.6 0.0 7.5e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 Cgr1 PF03879.14 EDP45131.1 - 0.013 15.8 8.3 0.021 15.2 8.3 1.2 1 0 0 1 1 1 0 Cgr1 family Gtr1_RagA PF04670.12 EDP45132.1 - 4.8e-32 111.2 0.2 8.7e-17 61.3 0.2 3.2 3 0 0 3 3 3 3 Gtr1/RagA G protein conserved region Arf PF00025.21 EDP45132.1 - 0.014 14.9 0.2 4 6.8 0.1 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDP45132.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain EF_TS PF00889.19 EDP45133.1 - 1.2e-13 51.2 0.0 7.1e-13 48.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor TS Nucleoporin_N PF08801.11 EDP45134.1 - 2.8e-44 151.6 0.0 4.8e-43 147.5 0.0 2.2 1 1 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EDP45134.1 - 1.8e-25 89.7 0.3 3e-25 89.0 0.3 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal DUF2722 PF10846.8 EDP45134.1 - 0.027 13.4 2.3 0.044 12.7 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RcpC PF16976.5 EDP45134.1 - 0.11 12.6 0.8 23 5.1 0.6 2.6 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB Spt20 PF12090.8 EDP45134.1 - 0.43 10.1 9.7 0.75 9.4 9.7 1.2 1 0 0 1 1 1 0 Spt20 family Mito_carr PF00153.27 EDP45135.1 - 1.3e-40 137.2 0.7 1.9e-16 59.8 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein LCM PF04072.14 EDP45136.1 - 7.2e-18 65.2 0.0 3e-17 63.2 0.0 1.9 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Fcf1 PF04900.12 EDP45137.1 - 1.5e-28 99.1 0.2 2.8e-28 98.2 0.2 1.5 1 0 0 1 1 1 1 Fcf1 SE PF08491.10 EDP45138.1 - 2.3e-84 282.7 0.0 1.8e-83 279.8 0.0 2.1 1 1 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EDP45138.1 - 1.3e-10 41.1 1.4 2.7e-09 36.8 1.4 2.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EDP45138.1 - 1.5e-09 37.9 0.3 0.00012 21.8 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EDP45138.1 - 8.4e-08 31.7 0.0 0.00028 20.1 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EDP45138.1 - 0.00019 21.6 0.5 0.00042 20.5 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 EDP45138.1 - 0.0016 18.5 0.0 0.0028 17.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 EDP45138.1 - 0.0047 15.8 0.1 1.1 8.1 0.2 2.3 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 EDP45138.1 - 0.0056 16.0 0.2 0.039 13.2 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EDP45138.1 - 0.011 14.8 3.8 0.022 13.9 0.7 2.4 3 0 0 3 3 3 0 FAD binding domain ApbA PF02558.16 EDP45138.1 - 0.013 15.2 0.1 0.024 14.3 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EDP45138.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EDP45138.1 - 0.017 14.4 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EDP45138.1 - 0.033 13.3 0.8 0.76 8.8 0.2 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Rossmann-like PF10727.9 EDP45138.1 - 0.044 13.6 0.3 0.16 11.9 0.1 1.9 2 0 0 2 2 2 0 Rossmann-like domain TrkA_N PF02254.18 EDP45138.1 - 0.047 13.9 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 EDP45138.1 - 0.052 12.9 0.1 0.085 12.2 0.1 1.2 1 0 0 1 1 1 0 ThiF family FAD_oxidored PF12831.7 EDP45138.1 - 0.064 12.6 2.5 0.12 11.7 2.5 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_2 PF03446.15 EDP45138.1 - 0.066 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_3 PF13738.6 EDP45138.1 - 0.082 12.1 0.1 1.7 7.8 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EDP45138.1 - 0.092 13.3 0.1 0.25 11.9 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 EDP45138.1 - 0.12 13.0 0.1 0.26 11.9 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EDP45138.1 - 0.15 12.3 0.1 0.28 11.4 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 EDP45138.1 - 0.2 11.6 0.0 0.48 10.4 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.14 EDP45138.1 - 0.21 10.3 0.1 0.33 9.6 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein GMC_oxred_N PF00732.19 EDP45138.1 - 0.24 10.7 0.3 19 4.5 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase ATP-synt_J PF04911.12 EDP45139.1 - 3.5e-25 87.3 0.6 4e-25 87.1 0.6 1.0 1 0 0 1 1 1 1 ATP synthase j chain Wzy_C_2 PF11846.8 EDP45139.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.0 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal AMP-binding PF00501.28 EDP45140.1 - 4.5e-71 239.7 0.0 1.4e-70 238.0 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDP45140.1 - 0.009 17.0 0.1 0.018 16.0 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Clathrin PF00637.20 EDP45141.1 - 1.1e-20 74.0 0.3 7.6e-12 45.3 0.1 2.7 2 1 0 2 2 2 2 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 EDP45141.1 - 2.7e-05 24.1 5.1 2.7e-05 24.1 5.1 2.0 2 0 0 2 2 2 1 Zinc-finger zf-C3HC4_2 PF13923.6 EDP45141.1 - 7e-05 22.6 6.6 0.00016 21.4 6.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP45141.1 - 0.00022 21.5 7.6 0.00056 20.2 7.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EDP45141.1 - 0.0032 17.4 4.9 0.0071 16.3 4.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EDP45141.1 - 0.012 15.6 5.2 0.02 14.9 2.9 2.3 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 EDP45141.1 - 0.017 14.8 8.0 0.39 10.5 4.1 3.2 3 0 0 3 3 3 0 RING-like zinc finger zf-C3HC4 PF00097.25 EDP45141.1 - 0.04 13.8 3.3 0.14 12.1 3.6 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) VPS11_C PF12451.8 EDP45141.1 - 0.055 13.7 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal zf-rbx1 PF12678.7 EDP45141.1 - 0.094 13.0 7.3 0.22 11.8 7.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF2946 PF11162.8 EDP45142.1 - 0.12 13.0 1.8 0.2 12.3 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) SpoIIP PF07454.11 EDP45143.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Med13_C PF06333.12 EDP45143.1 - 0.09 12.0 3.5 0.095 11.9 3.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain DUF2722 PF10846.8 EDP45143.1 - 0.34 9.8 12.7 0.47 9.3 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CCDC53 PF10152.9 EDP45143.1 - 0.38 11.1 3.6 0.57 10.6 3.6 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Spt20 PF12090.8 EDP45143.1 - 1.5 8.4 20.2 2.2 7.9 20.2 1.1 1 0 0 1 1 1 0 Spt20 family Totivirus_coat PF05518.11 EDP45143.1 - 4.5 5.2 7.2 6.7 4.6 7.2 1.2 1 0 0 1 1 1 0 Totivirus coat protein SARAF PF06682.12 EDP45144.1 - 0.14 11.8 23.6 0.27 10.8 23.6 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GREB1 PF15782.5 EDP45144.1 - 0.98 6.5 6.2 1.1 6.3 6.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MGC-24 PF05283.11 EDP45144.1 - 2.4 8.6 12.8 3.5 8.1 12.8 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Apt1 PF10351.9 EDP45144.1 - 6.1 5.6 7.6 7.6 5.3 7.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ras PF00071.22 EDP45145.1 - 3.6e-10 39.7 0.1 4.4e-10 39.4 0.1 1.2 1 0 0 1 1 1 1 Ras family LytR_C PF13399.6 EDP45145.1 - 0.026 15.5 0.5 10 7.2 0.1 2.3 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator ATP-synt_10 PF05176.14 EDP45146.1 - 3.2e-34 118.3 0.0 3.6e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein U3_assoc_6 PF08640.11 EDP45147.1 - 7.6e-16 58.0 2.6 3.9e-15 55.7 2.1 2.4 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 DNA_primase_lrg PF04104.14 EDP45148.1 - 5.2e-80 268.7 0.0 1.1e-79 267.6 0.0 1.5 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit PIP5K PF01504.18 EDP45149.1 - 5.2e-89 298.1 0.0 1e-88 297.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Nop14 PF04147.12 EDP45150.1 - 0.014 13.6 2.2 0.017 13.4 2.2 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDP45150.1 - 0.038 13.3 15.4 0.058 12.7 15.4 1.2 1 0 0 1 1 1 0 NOA36 protein TFIIA PF03153.13 EDP45150.1 - 0.084 12.9 8.4 0.13 12.2 8.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 EDP45150.1 - 0.12 12.3 3.1 0.18 11.7 3.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF2076 PF09849.9 EDP45150.1 - 0.12 12.4 8.0 0.25 11.4 8.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PPP4R2 PF09184.11 EDP45150.1 - 0.27 10.8 7.4 0.38 10.3 7.4 1.2 1 0 0 1 1 1 0 PPP4R2 M_domain PF12938.7 EDP45150.1 - 0.65 9.7 2.2 0.53 10.0 0.6 1.6 2 0 0 2 2 2 0 M domain of GW182 DNA_pol_phi PF04931.13 EDP45150.1 - 1.8 6.5 19.2 2.6 6.0 19.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 EDP45150.1 - 2.6 7.9 8.0 5.1 6.9 8.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.11 EDP45150.1 - 3.6 7.6 7.9 6.3 6.8 7.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 EDP45150.1 - 7.1 5.7 8.3 10 5.2 8.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein His_biosynth PF00977.21 EDP45151.1 - 1.5e-39 135.8 0.0 4e-19 69.0 0.0 3.7 3 1 0 3 3 3 3 Histidine biosynthesis protein GATase PF00117.28 EDP45151.1 - 4.5e-12 46.1 0.0 1.2e-11 44.8 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EDP45151.1 - 0.00044 19.9 0.1 0.0013 18.4 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EDP45151.1 - 0.0037 17.0 0.4 0.067 12.9 0.1 2.2 2 0 0 2 2 2 1 Peptidase C26 SNO PF01174.19 EDP45151.1 - 0.016 15.0 0.0 0.83 9.5 0.0 2.4 2 0 0 2 2 2 0 SNO glutamine amidotransferase family PhoD PF09423.10 EDP45152.1 - 1.1e-33 116.8 0.0 2.6e-33 115.5 0.0 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase Ribosomal_S7 PF00177.21 EDP45153.1 - 3.4e-33 114.4 0.0 4.4e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Glyco_trans_1_3 PF13528.6 EDP45153.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 HATPase_c PF02518.26 EDP45154.1 - 1.8e-20 73.5 0.1 4.4e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EDP45154.1 - 2e-15 56.6 0.1 8e-15 54.6 0.1 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EDP45154.1 - 5e-14 52.4 0.0 4.2e-09 36.6 0.0 2.8 1 1 1 2 2 2 2 Response regulator receiver domain GAF PF01590.26 EDP45154.1 - 0.0033 18.1 0.0 0.013 16.1 0.0 2.0 2 0 0 2 2 2 1 GAF domain zf-C2H2 PF00096.26 EDP45155.1 - 5.8e-12 45.4 8.1 5.1e-05 23.5 4.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP45155.1 - 1.4e-08 34.9 7.3 0.0028 18.4 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP45155.1 - 3.6e-08 33.5 8.1 1.2e-05 25.5 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EDP45155.1 - 2.3e-05 24.6 0.1 0.2 12.0 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EDP45155.1 - 0.00094 19.1 2.1 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 EDP45155.1 - 0.0018 18.6 0.9 0.25 11.8 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EDP45155.1 - 0.0095 15.7 4.3 0.092 12.5 1.2 3.0 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-MYST PF17772.1 EDP45155.1 - 0.027 14.1 0.4 6.8 6.4 0.0 2.4 1 1 1 2 2 2 0 MYST family zinc finger domain zf-Di19 PF05605.12 EDP45155.1 - 0.045 14.1 0.7 0.076 13.3 0.7 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 EDP45155.1 - 0.046 14.2 0.1 1.5 9.3 0.1 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_SprT PF17283.2 EDP45155.1 - 0.19 11.7 6.1 0.4 10.6 6.1 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain zf-C2H2_2 PF12756.7 EDP45155.1 - 0.32 11.3 1.4 9 6.7 0.0 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 EDP45155.1 - 0.38 10.8 2.8 46 4.1 2.8 2.5 1 1 0 1 1 1 0 BED zinc finger zf_C2H2_ZHX PF18387.1 EDP45155.1 - 0.59 9.8 3.0 16 5.2 2.7 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HC_2 PF13913.6 EDP45155.1 - 9.7 6.2 7.5 17 5.4 1.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type TFIIB PF00382.19 EDP45156.1 - 6.1e-12 45.4 0.4 1.1e-11 44.6 0.4 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat SpoIIID PF12116.8 EDP45156.1 - 0.14 12.3 0.4 0.22 11.6 0.4 1.3 1 0 0 1 1 1 0 Stage III sporulation protein D Nup84_Nup100 PF04121.13 EDP45157.1 - 9.9e-129 430.6 0.0 1.1e-128 430.4 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Brix PF04427.18 EDP45158.1 - 4.6e-24 85.6 0.0 7e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Brix domain Merozoite_SPAM PF07133.11 EDP45158.1 - 0.003 17.6 14.2 0.0054 16.8 14.2 1.4 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) Nop14 PF04147.12 EDP45158.1 - 1.1 7.4 19.9 1.4 7.0 19.9 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDP45158.1 - 1.9 7.8 13.8 3.1 7.0 13.8 1.4 1 0 0 1 1 1 0 NOA36 protein FCH PF00611.23 EDP45159.1 - 1.9e-16 60.1 0.4 1.9e-16 60.1 0.4 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EDP45159.1 - 6.5e-11 41.7 0.0 1.2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EDP45159.1 - 6.5e-09 35.5 0.0 1.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EDP45159.1 - 7.5e-08 31.9 0.0 1.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TPR_MLP1_2 PF07926.12 EDP45159.1 - 0.0029 17.7 4.9 0.0029 17.7 4.9 2.4 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein EcoEI_R_C PF08463.10 EDP45159.1 - 0.011 15.8 3.8 0.017 15.2 3.5 1.5 1 1 0 1 1 1 0 EcoEI R protein C-terminal Streptin-Immun PF11083.8 EDP45159.1 - 0.15 12.5 1.9 0.47 10.9 0.7 2.2 2 1 0 2 2 2 0 Lantibiotic streptin immunity protein Adhesin_P1_N PF18652.1 EDP45159.1 - 0.32 11.0 2.5 2.5 8.2 0.1 2.6 2 1 0 2 2 2 0 Adhesin P1 N-terminal domain GCN5L1 PF06320.13 EDP45159.1 - 2.9 8.1 5.9 1.8 8.7 3.5 1.9 1 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF4407 PF14362.6 EDP45159.1 - 4.7 6.5 5.3 7.5 5.8 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CorA PF01544.18 EDP45160.1 - 5.3e-12 45.7 6.7 0.00085 18.7 0.1 3.2 2 1 0 3 3 3 3 CorA-like Mg2+ transporter protein BUD22 PF09073.10 EDP45160.1 - 0.35 10.1 14.3 0.61 9.4 14.3 1.4 1 0 0 1 1 1 0 BUD22 TFIIA PF03153.13 EDP45160.1 - 3.9 7.4 9.8 6.3 6.7 9.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleo_P87 PF07267.11 EDP45160.1 - 7.5 5.3 10.4 15 4.3 10.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PCNA_C PF02747.15 EDP45161.1 - 2.5e-40 137.6 0.7 1.1e-21 77.3 0.0 2.2 2 0 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 EDP45161.1 - 5.5e-30 103.7 0.2 2.5e-29 101.6 0.3 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 EDP45161.1 - 0.0093 15.1 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 RTA1 PF04479.13 EDP45162.1 - 7.5e-56 189.0 1.5 1.1e-55 188.5 1.5 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF2981 PF11200.8 EDP45162.1 - 0.06 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Cyclin PF08613.11 EDP45163.1 - 1.2e-09 38.7 0.0 1.8e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EDP45163.1 - 0.029 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain SET PF00856.28 EDP45164.1 - 7.2e-07 29.7 0.0 1.8e-05 25.2 0.0 3.1 3 1 0 3 3 3 1 SET domain Peptidase_S8 PF00082.22 EDP45165.1 - 5.6e-66 222.8 0.5 8.6e-66 222.2 0.5 1.2 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 EDP45165.1 - 1.5e-50 171.4 0.0 2.4e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Tripeptidyl peptidase II DUF3829 PF12889.7 EDP45165.1 - 0.2 11.1 0.1 0.33 10.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) GDI PF00996.18 EDP45166.1 - 2.7e-33 115.1 0.0 4.8e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor Peptidase_S49 PF01343.18 EDP45167.1 - 1.1e-41 142.3 0.0 6.2e-26 91.2 0.2 3.2 3 0 0 3 3 3 2 Peptidase family S49 CLP_protease PF00574.23 EDP45167.1 - 8.3e-07 29.1 0.6 5e-05 23.3 0.3 2.8 3 0 0 3 3 3 1 Clp protease DPBB_1 PF03330.18 EDP45168.1 - 1.4e-10 41.3 0.0 2.7e-10 40.4 0.0 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EDP45168.1 - 0.066 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Barwin family DUF1180 PF06679.12 EDP45168.1 - 0.34 11.3 2.1 0.48 10.8 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) FAM199X PF15814.5 EDP45168.1 - 4.5 6.2 11.2 5.8 5.9 11.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X TRAM_LAG1_CLN8 PF03798.16 EDP45169.1 - 3.2e-35 121.7 27.5 3.2e-35 121.7 27.5 3.0 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EDP45169.1 - 1.8e-05 24.3 0.0 1.8e-05 24.3 0.0 4.1 4 1 1 5 5 5 1 TRAM1-like protein PBP_N PF17093.5 EDP45169.1 - 0.11 12.8 0.1 0.11 12.8 0.1 3.3 4 0 0 4 4 4 0 Penicillin-binding protein N-terminus Aldedh PF00171.22 EDP45170.1 - 1.3e-10 40.4 0.9 3.8e-10 38.9 0.9 1.8 1 1 0 1 1 1 1 Aldehyde dehydrogenase family FlgT_N PF16548.5 EDP45170.1 - 0.15 12.6 1.2 1.6 9.3 0.0 2.4 2 0 0 2 2 2 0 Flagellar assembly protein T, N-terminal domain SesA PF17107.5 EDP45170.1 - 0.23 11.6 1.3 1.8 8.8 1.3 2.3 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF2802 PF10975.8 EDP45170.1 - 0.7 10.1 3.5 8.7 6.6 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) XPG_I PF00867.18 EDP45172.1 - 1.9e-11 44.1 0.1 3.9e-11 43.2 0.0 1.5 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 EDP45172.1 - 1.1e-07 32.4 0.0 1.6e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold DNA_pol_lambd_f PF10391.9 EDP45172.1 - 0.02 14.7 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda Fe_dep_repr_C PF02742.15 EDP45172.1 - 0.07 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain HHH_5 PF14520.6 EDP45172.1 - 0.13 12.9 0.1 0.24 12.0 0.1 1.5 1 1 0 1 1 1 0 Helix-hairpin-helix domain SKN1 PF03935.15 EDP45173.1 - 2.9e-169 563.7 6.8 4e-169 563.2 6.8 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SKN1 PF03935.15 EDP45174.1 - 1.3e-171 571.4 4.9 1.8e-171 571.0 4.9 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) DNA_pol_B_exo2 PF10108.9 EDP45174.1 - 0.024 14.3 0.1 0.04 13.6 0.1 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zf-C2H2 PF00096.26 EDP45175.1 - 3.2e-13 49.3 15.0 1.3e-05 25.3 0.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP45175.1 - 4.2e-10 39.6 14.0 0.003 18.3 0.4 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDP45175.1 - 4e-09 36.2 0.8 0.00054 19.9 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EDP45175.1 - 2.1e-05 24.8 8.8 0.19 12.2 0.4 4.4 4 0 0 4 4 4 3 Zinc-finger double domain ADK_lid PF05191.14 EDP45175.1 - 0.11 12.5 1.9 5.7 7.0 0.1 2.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid zinc_ribbon_4 PF13717.6 EDP45175.1 - 0.11 12.4 2.3 8.6 6.4 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zf_ZIC PF18366.1 EDP45175.1 - 0.15 12.2 0.2 4.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2HE PF16278.5 EDP45175.1 - 0.17 12.4 2.3 4.4 7.8 0.3 3.4 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EDP45175.1 - 0.62 9.9 13.0 1.9 8.3 1.4 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EDP45175.1 - 2 8.6 4.2 14 5.9 0.6 2.7 2 0 0 2 2 2 0 Zinc ribbon domain FYVE PF01363.21 EDP45175.1 - 4.6 7.5 7.6 3.7 7.8 2.1 2.6 2 0 0 2 2 2 0 FYVE zinc finger SET PF00856.28 EDP45176.1 - 1.1e-11 45.4 3.5 9.1e-10 39.2 3.5 2.7 2 1 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EDP45176.1 - 4.6e-06 27.4 0.0 1.1e-05 26.2 0.0 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Cwf_Cwc_15 PF04889.12 EDP45176.1 - 0.02 14.6 13.2 0.035 13.8 13.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 EDP45176.1 - 0.087 12.2 13.9 0.13 11.6 13.9 1.2 1 0 0 1 1 1 0 SDA1 Myc_N PF01056.18 EDP45176.1 - 0.17 11.7 6.6 0.33 10.8 6.6 1.4 1 0 0 1 1 1 0 Myc amino-terminal region TFIIA PF03153.13 EDP45176.1 - 0.58 10.1 13.1 0.91 9.5 13.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 EDP45176.1 - 0.87 7.8 11.2 1.2 7.4 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EDP45176.1 - 0.97 7.6 20.2 1.3 7.1 20.2 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EDP45176.1 - 1.4 8.2 19.9 2.2 7.5 19.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF913 PF06025.12 EDP45176.1 - 2 7.3 3.9 2.7 6.9 3.1 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 EDP45176.1 - 2.3 8.4 5.1 4.3 7.5 5.1 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 EDP45176.1 - 2.4 7.4 16.5 3.7 6.8 16.5 1.2 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 EDP45176.1 - 4.3 6.8 19.5 6.9 6.2 19.5 1.3 1 0 0 1 1 1 0 PPP4R2 Tub_N PF16322.5 EDP45176.1 - 4.5 7.6 13.5 7.9 6.8 13.5 1.3 1 0 0 1 1 1 0 Tubby N-terminal DNA_pol_phi PF04931.13 EDP45176.1 - 5.2 5.0 27.1 7.7 4.5 27.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi RPN2_C PF18004.1 EDP45176.1 - 6 6.8 7.6 11 5.9 7.6 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Steroid_dh PF02544.16 EDP45177.1 - 1.8e-38 131.9 0.5 1.8e-38 131.9 0.5 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EDP45177.1 - 1.5e-05 24.7 0.2 2.4e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EDP45177.1 - 0.0098 16.3 2.9 0.01 16.2 0.8 2.1 2 1 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 EDP45177.1 - 0.024 15.0 1.8 0.029 14.8 0.6 1.8 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PRA1 PF03208.19 EDP45177.1 - 0.11 12.2 0.1 0.11 12.2 0.1 2.2 2 1 0 2 2 2 0 PRA1 family protein CLASP_N PF12348.8 EDP45178.1 - 7.4e-18 64.9 0.0 1.1e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 EDP45178.1 - 0.00057 19.9 2.2 0.001 19.2 0.1 2.6 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 EDP45178.1 - 0.0027 18.2 0.3 0.05 14.1 0.0 2.9 2 1 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.6 EDP45178.1 - 0.034 14.5 0.2 0.26 11.7 0.2 2.4 1 1 0 1 1 1 0 HEAT repeats TFCD_C PF12612.8 EDP45178.1 - 0.073 12.9 0.2 0.14 11.9 0.0 1.5 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal Skp1_POZ PF03931.15 EDP45179.1 - 1.9e-09 37.6 0.0 3.1e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain ATP-synt_C PF00137.21 EDP45182.1 - 4.5e-25 87.8 31.0 1e-15 57.8 11.9 2.7 3 0 0 3 3 3 2 ATP synthase subunit C Peptidase_C13 PF01650.18 EDP45183.1 - 3.1e-45 154.7 0.0 3.9e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family DS PF01916.17 EDP45184.1 - 1.5e-129 431.4 0.0 1.7e-129 431.2 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ThiF PF00899.21 EDP45185.1 - 5.1e-63 212.7 0.0 6.6e-63 212.3 0.0 1.0 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EDP45185.1 - 0.0052 16.9 0.2 0.012 15.7 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EDP45185.1 - 0.025 14.1 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EDP45185.1 - 0.027 15.0 0.0 0.052 14.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EDP45185.1 - 0.033 13.8 0.0 0.068 12.8 0.0 1.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA UBA_e1_thiolCys PF10585.9 EDP45185.1 - 0.066 13.1 0.1 4.5 7.1 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site zf-C3HC4_3 PF13920.6 EDP45185.1 - 0.098 12.5 2.6 20 5.1 0.0 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PglD_N PF17836.1 EDP45185.1 - 0.11 13.2 0.0 0.27 11.9 0.0 1.7 1 0 0 1 1 1 0 PglD N-terminal domain Ecm33 PF12454.8 EDP45185.1 - 0.15 12.2 1.9 0.28 11.3 1.9 1.4 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein G-patch PF01585.23 EDP45187.1 - 5.5e-12 45.4 0.5 5.5e-12 45.4 0.5 2.3 2 1 0 2 2 2 1 G-patch domain R3H PF01424.22 EDP45187.1 - 4.1e-11 42.7 0.0 1.2e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 R3H domain G-patch_2 PF12656.7 EDP45187.1 - 5e-06 26.5 0.5 1.2e-05 25.3 0.2 1.7 1 1 1 2 2 2 1 G-patch domain SIR2 PF02146.17 EDP45189.1 - 3.2e-20 72.8 0.0 8.2e-20 71.5 0.0 1.6 2 0 0 2 2 2 1 Sir2 family DUF592 PF04574.13 EDP45189.1 - 4.2e-05 23.4 0.2 0.00016 21.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF592) CutC PF03932.14 EDP45189.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 CutC family DUF1769 PF08588.10 EDP45190.1 - 1.3e-13 50.9 0.8 3.3e-13 49.6 0.8 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) SURF6 PF04935.12 EDP45191.1 - 9.4e-20 71.3 35.9 3.1e-19 69.6 35.9 1.6 1 1 0 1 1 1 1 Surfeit locus protein 6 Spt20 PF12090.8 EDP45191.1 - 1.4 8.5 5.4 0.34 10.5 1.9 1.6 2 0 0 2 2 2 0 Spt20 family Pkinase_fungal PF17667.1 EDP45191.1 - 3 6.5 11.1 3.4 6.3 11.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Fmp27_SW PF10305.9 EDP45191.1 - 9.8 7.0 8.3 1.6 9.5 2.7 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain WD40 PF00400.32 EDP45192.1 - 3.7e-65 214.3 26.1 8.3e-10 39.1 0.1 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45192.1 - 4.4e-21 75.0 2.4 0.00066 19.9 0.0 5.8 3 3 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP45192.1 - 2e-06 27.0 0.1 0.3 10.0 0.0 4.2 3 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EDP45192.1 - 0.0001 22.2 0.0 0.0017 18.2 0.0 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EDP45192.1 - 0.00027 19.7 5.2 1.5 7.3 0.1 4.6 4 1 1 5 5 5 2 Nucleoporin Nup120/160 NLE PF08154.12 EDP45192.1 - 0.0004 20.8 0.0 0.00077 19.9 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nbas_N PF15492.6 EDP45192.1 - 0.0012 18.2 0.3 5 6.4 0.1 3.6 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 EDP45192.1 - 0.0041 15.2 0.9 0.0079 14.2 0.0 1.7 2 0 0 2 2 2 1 IKI3 family WD40_like PF17005.5 EDP45192.1 - 0.2 10.9 0.0 3 7.1 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Coatomer_WDAD PF04053.14 EDP45192.1 - 0.23 10.5 0.0 0.41 9.6 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region UQ_con PF00179.26 EDP45193.1 - 1.3e-39 135.0 0.1 2.6e-19 69.3 0.2 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme BRO1 PF03097.18 EDP45195.1 - 2.7e-49 168.0 0.5 2.7e-49 168.0 0.5 2.3 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EDP45195.1 - 1.2e-21 77.3 11.3 2.9e-21 76.1 11.3 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3510 PF12022.8 EDP45195.1 - 3.3 8.1 6.8 4.3 7.7 0.2 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF3510) WGG PF10273.9 EDP45196.1 - 9e-20 71.1 0.0 1.6e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF3425 PF11905.8 EDP45196.1 - 0.0095 15.9 0.0 0.011 15.7 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) EcoEI_R_C PF08463.10 EDP45196.1 - 0.099 12.8 0.1 8.7 6.4 0.1 2.1 2 0 0 2 2 2 0 EcoEI R protein C-terminal Anophelin PF10731.9 EDP45196.1 - 0.2 11.5 1.7 0.24 11.3 0.2 1.9 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito adh_short PF00106.25 EDP45197.1 - 2.7e-51 173.8 1.2 3.9e-51 173.3 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP45197.1 - 1e-34 120.1 2.0 1.2e-34 119.9 2.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP45197.1 - 1.3e-07 31.7 0.7 1.7e-07 31.3 0.7 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EDP45197.1 - 0.014 15.3 0.2 0.024 14.5 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EDP45197.1 - 0.017 14.6 0.3 0.08 12.4 0.3 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EDP45197.1 - 0.048 13.0 0.1 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain COG4 PF08318.12 EDP45198.1 - 1.7e-53 181.9 0.2 1.9e-52 178.4 0.2 2.3 1 1 0 1 1 1 1 COG4 transport protein OHCU_decarbox PF09349.10 EDP45199.1 - 0.00018 22.0 0.0 0.0078 16.7 0.0 2.5 1 1 1 2 2 2 2 OHCU decarboxylase Forkhead PF00250.18 EDP45200.1 - 2.3e-10 40.6 0.0 4.2e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain APS_kinase PF01583.20 EDP45201.1 - 3.1e-70 235.2 0.0 3.6e-70 234.9 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EDP45201.1 - 5.4e-06 26.6 0.0 9.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EDP45201.1 - 0.00011 22.7 0.0 0.0002 21.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EDP45201.1 - 0.00045 19.7 0.0 0.00047 19.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.6 EDP45201.1 - 0.003 17.3 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EDP45201.1 - 0.027 13.7 0.0 0.071 12.4 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Thymidylate_kin PF02223.17 EDP45201.1 - 0.075 12.7 0.1 1.3 8.7 0.0 2.1 1 1 1 2 2 2 0 Thymidylate kinase ABC_tran PF00005.27 EDP45201.1 - 0.081 13.4 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.20 EDP45201.1 - 0.1 11.7 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_14 PF13173.6 EDP45201.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain SHNi-TPR PF10516.9 EDP45202.1 - 1.2e-07 31.1 0.1 3.6e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 SHNi-TPR ANAPC15 PF15243.6 EDP45202.1 - 2.8 8.4 16.6 9.4 6.7 9.8 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 DUF2973 PF11189.8 EDP45203.1 - 0.23 11.6 0.0 0.33 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) La PF05383.17 EDP45204.1 - 3.6e-17 62.1 0.2 6.7e-17 61.3 0.2 1.4 1 0 0 1 1 1 1 La domain Macoilin PF09726.9 EDP45204.1 - 5.3 5.5 15.4 9.5 4.6 15.4 1.4 1 0 0 1 1 1 0 Macoilin family PhoPQ_related PF10142.9 EDP45206.1 - 0.00015 20.5 0.3 0.00022 20.0 0.3 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Acyl-CoA_dh_2 PF08028.11 EDP45206.1 - 0.076 13.3 0.9 0.15 12.3 0.6 1.7 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain AIP3 PF03915.13 EDP45206.1 - 0.1 11.7 14.9 0.13 11.4 14.9 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Phage_tube PF04985.14 EDP45206.1 - 0.12 12.1 1.4 0.51 10.0 0.8 2.0 1 1 1 2 2 2 0 Phage tail tube protein FII DUF1664 PF07889.12 EDP45206.1 - 0.17 12.0 9.8 0.047 13.7 6.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 EDP45206.1 - 0.18 11.3 19.4 0.93 8.9 14.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF4559 PF15112.6 EDP45206.1 - 0.27 10.9 10.8 0.37 10.4 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Baculo_PEP_C PF04513.12 EDP45206.1 - 0.33 11.0 8.6 0.73 9.9 4.3 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 EDP45206.1 - 0.35 11.4 18.0 0.15 12.6 13.1 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region PMSR PF01625.21 EDP45206.1 - 0.72 10.0 3.0 5.4 7.2 0.4 2.4 1 1 0 2 2 2 0 Peptide methionine sulfoxide reductase Prominin PF05478.11 EDP45206.1 - 1.1 7.1 10.4 1.3 6.8 10.4 1.0 1 0 0 1 1 1 0 Prominin Fib_alpha PF08702.10 EDP45206.1 - 1.3 9.2 12.3 0.1 12.8 5.4 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.22 EDP45206.1 - 1.5 9.1 10.6 1.1 9.5 4.2 2.7 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 EDP45206.1 - 1.6 8.8 17.5 0.19 11.8 9.0 2.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 EDP45206.1 - 1.8 9.3 9.7 3 8.5 4.1 2.6 1 1 1 2 2 2 0 Initiation control protein YabA KELK PF15796.5 EDP45206.1 - 2.2 8.8 11.8 1.5 9.3 6.2 2.7 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase YlqD PF11068.8 EDP45206.1 - 2.7 8.4 17.2 60 4.0 16.5 2.3 1 1 0 1 1 1 0 YlqD protein KfrA_N PF11740.8 EDP45206.1 - 2.8 8.6 13.2 1.3 9.7 1.6 3.1 1 1 2 3 3 3 0 Plasmid replication region DNA-binding N-term TSC22 PF01166.18 EDP45206.1 - 3.8 7.9 6.6 0.45 10.9 1.2 2.4 3 0 0 3 3 3 0 TSC-22/dip/bun family Sec34 PF04136.15 EDP45206.1 - 5 7.0 13.7 0.46 10.4 5.7 2.1 1 1 1 2 2 2 0 Sec34-like family DUF3450 PF11932.8 EDP45206.1 - 9.3 5.5 18.4 0.4 10.0 10.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BRAP2 PF07576.12 EDP45207.1 - 1.7e-18 66.7 0.0 3.4e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-RING_2 PF13639.6 EDP45207.1 - 1.2e-08 35.1 10.3 2.7e-08 34.0 10.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP45207.1 - 1.2e-06 28.3 9.1 1.2e-06 28.3 9.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EDP45207.1 - 6.5e-06 26.3 5.3 6.5e-06 26.3 5.3 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDP45207.1 - 1.2e-05 25.2 3.7 5e-05 23.2 1.8 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDP45207.1 - 0.00038 20.3 7.9 0.00038 20.3 7.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EDP45207.1 - 0.00083 19.2 8.1 0.00083 19.2 8.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDP45207.1 - 0.0019 17.9 4.6 0.0019 17.9 4.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_4 PF14570.6 EDP45207.1 - 0.004 16.9 6.2 0.004 16.9 6.2 2.0 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 EDP45207.1 - 0.0042 17.0 8.6 0.0042 17.0 8.6 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EDP45207.1 - 0.0066 16.5 6.8 0.0066 16.5 6.8 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 EDP45207.1 - 0.041 14.0 5.2 0.25 11.6 5.3 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RRM_1 PF00076.22 EDP45207.1 - 0.044 13.6 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prok-RING_4 PF14447.6 EDP45207.1 - 0.4 10.6 17.2 0.083 12.8 7.2 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Zn-ribbon_8 PF09723.10 EDP45207.1 - 2.3 8.4 8.2 19 5.5 3.1 3.4 3 0 0 3 3 3 0 Zinc ribbon domain Zn_ribbon_17 PF17120.5 EDP45207.1 - 5.8 6.6 12.8 4.6 6.9 9.7 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type Pkinase PF00069.25 EDP45208.1 - 5.3e-42 144.0 0.0 1.1e-30 106.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45208.1 - 1.1e-23 83.8 0.0 1.6e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP45208.1 - 3.1e-07 29.5 0.0 1.9e-06 27.0 0.0 1.9 1 1 1 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EDP45208.1 - 0.00089 18.7 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AAA PF00004.29 EDP45209.1 - 7.4e-96 317.6 0.0 1.7e-46 157.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP45209.1 - 2.9e-27 94.2 3.1 1.7e-13 50.1 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EDP45209.1 - 6.5e-15 55.1 0.1 1.9e-14 53.6 0.1 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EDP45209.1 - 4.3e-14 52.6 0.1 1.1e-05 25.3 0.0 3.4 2 2 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EDP45209.1 - 1.2e-12 48.3 0.0 2.7e-07 30.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EDP45209.1 - 1.1e-11 45.1 0.0 6.6e-06 26.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 EDP45209.1 - 1.5e-11 43.9 0.0 3.5e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 EDP45209.1 - 2.4e-11 43.8 0.5 2.4e-05 24.4 0.1 3.4 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EDP45209.1 - 1.6e-10 41.6 0.0 0.00073 20.0 0.0 4.2 2 2 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 EDP45209.1 - 3.6e-09 36.3 0.1 0.0016 17.7 0.1 2.5 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EDP45209.1 - 1.2e-08 35.3 0.2 0.048 13.9 0.0 4.0 3 2 1 4 4 3 2 AAA domain IstB_IS21 PF01695.17 EDP45209.1 - 2.1e-07 30.9 0.0 0.01 15.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDP45209.1 - 4.3e-07 29.5 0.4 0.026 13.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EDP45209.1 - 1.1e-06 28.1 0.3 0.57 9.5 0.0 3.5 3 0 0 3 3 3 2 KaiC AAA_18 PF13238.6 EDP45209.1 - 1.1e-06 29.2 0.1 0.035 14.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 EDP45209.1 - 1.2e-06 28.3 3.0 0.34 10.5 0.0 4.4 3 2 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 EDP45209.1 - 1.7e-06 28.4 0.0 0.02 15.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_7 PF12775.7 EDP45209.1 - 2.9e-06 26.9 0.0 0.027 14.0 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EDP45209.1 - 4e-06 26.9 0.0 0.022 14.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 EDP45209.1 - 5.1e-06 25.8 0.1 0.0055 15.8 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ABC_tran PF00005.27 EDP45209.1 - 8.3e-06 26.4 0.0 0.049 14.2 0.0 3.2 2 1 0 2 2 2 1 ABC transporter Sigma54_activat PF00158.26 EDP45209.1 - 1.8e-05 24.5 0.0 0.41 10.3 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.6 EDP45209.1 - 2e-05 24.9 0.0 0.2 11.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 EDP45209.1 - 4.3e-05 23.4 0.2 0.00073 19.5 0.1 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain PhoH PF02562.16 EDP45209.1 - 4.3e-05 23.1 0.1 0.36 10.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein Bac_DnaA PF00308.18 EDP45209.1 - 6.4e-05 22.9 0.0 0.15 11.9 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_24 PF13479.6 EDP45209.1 - 8.6e-05 22.3 0.0 0.49 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 EDP45209.1 - 0.00011 21.4 0.0 0.03 13.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 EDP45209.1 - 0.00025 21.0 0.0 0.24 11.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EDP45209.1 - 0.00028 20.9 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 EDP45209.1 - 0.00034 20.5 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EDP45209.1 - 0.00066 19.5 0.0 1.1 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EDP45209.1 - 0.00093 18.5 0.0 0.47 9.6 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 EDP45209.1 - 0.00093 19.6 2.3 0.85 10.0 0.0 3.1 4 0 0 4 4 2 2 AAA domain Sigma54_activ_2 PF14532.6 EDP45209.1 - 0.0014 18.8 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_30 PF13604.6 EDP45209.1 - 0.0019 18.0 0.4 2.2 8.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EDP45209.1 - 0.0022 17.9 0.2 0.68 9.8 0.0 3.1 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 EDP45209.1 - 0.0032 17.8 0.8 2.6 8.4 0.0 3.1 2 1 1 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EDP45209.1 - 0.0063 15.8 0.0 3.5 6.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin ATPase_2 PF01637.18 EDP45209.1 - 0.0068 16.4 0.1 11 5.9 0.0 3.2 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EDP45209.1 - 0.0079 16.0 0.0 0.52 10.0 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 EDP45209.1 - 0.014 14.6 0.0 0.85 8.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 EDP45209.1 - 0.037 14.0 0.4 6.5 6.6 0.0 3.4 3 0 0 3 3 3 0 NTPase IPT PF01745.16 EDP45209.1 - 0.037 13.4 0.0 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.14 EDP45209.1 - 0.04 13.2 0.0 0.49 9.6 0.0 2.5 2 1 0 3 3 3 0 KAP family P-loop domain T2SSE PF00437.20 EDP45209.1 - 0.057 12.5 0.0 0.98 8.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EDP45209.1 - 0.059 13.1 0.0 8.7 6.0 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase PIF1 PF05970.14 EDP45209.1 - 0.16 11.1 0.0 11 5.1 0.0 3.1 3 0 0 3 3 3 0 PIF1-like helicase Zot PF05707.12 EDP45209.1 - 0.17 11.5 0.0 6.1 6.4 0.0 2.8 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_6 PF12774.7 EDP45209.1 - 0.21 10.5 0.1 7.9 5.3 0.0 2.3 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region PI-PLC-X PF00388.19 EDP45211.1 - 0.0015 18.1 0.1 0.0051 16.4 0.0 1.8 2 1 1 3 3 3 1 Phosphatidylinositol-specific phospholipase C, X domain HSP70 PF00012.20 EDP45212.1 - 1e-154 516.1 0.0 4.1e-154 514.0 0.0 1.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EDP45212.1 - 3.7e-10 39.1 0.0 6.3e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Peptidase_U49 PF10463.9 EDP45212.1 - 0.015 15.1 0.4 0.034 13.9 0.4 1.5 1 0 0 1 1 1 0 Peptidase U49 Ribosomal_L30_N PF08079.12 EDP45213.1 - 1.8e-28 98.6 13.7 4.5e-28 97.3 13.7 1.7 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EDP45213.1 - 4.7e-18 64.8 0.6 1.4e-17 63.3 0.6 1.9 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e PX PF00787.24 EDP45214.1 - 1.7e-21 76.3 0.4 2.4e-21 75.8 0.4 1.2 1 0 0 1 1 1 1 PX domain FA_hydroxylase PF04116.13 EDP45215.1 - 3.7e-24 85.6 13.7 3.7e-24 85.6 13.7 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily SIR2 PF02146.17 EDP45217.1 - 5.4e-55 186.0 0.0 1e-54 185.2 0.0 1.4 2 0 0 2 2 2 1 Sir2 family A_deamin PF02137.18 EDP45218.1 - 1.7e-36 126.3 0.0 2.5e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain zf-CCHC PF00098.23 EDP45219.1 - 4e-14 51.9 21.5 9.5e-05 22.3 0.6 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 EDP45219.1 - 0.0001 22.0 20.0 0.04 13.7 0.3 4.3 4 1 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 EDP45219.1 - 0.00033 20.3 19.2 0.21 11.3 0.8 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.6 EDP45219.1 - 0.002 18.1 10.9 1.1 9.3 1.0 3.5 1 1 2 3 3 3 3 Zinc knuckle PHD_4 PF16866.5 EDP45219.1 - 0.037 14.1 14.0 0.63 10.2 1.1 2.9 1 1 2 3 3 3 0 PHD-finger zf-CCHC_6 PF15288.6 EDP45219.1 - 0.054 13.3 11.8 0.29 11.0 1.2 3.6 3 0 0 3 3 3 0 Zinc knuckle Pns11_12 PF17464.2 EDP45219.1 - 0.64 9.7 6.4 9.4 5.9 0.0 3.2 3 0 0 3 3 3 0 Non-structural protein 11 and 12 zf-CCHC_5 PF14787.6 EDP45219.1 - 6.4 6.6 20.6 1.6 8.5 0.3 4.1 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger V-SNARE_C PF12352.8 EDP45220.1 - 1.1e-13 51.2 1.7 2.1e-13 50.3 1.7 1.4 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EDP45220.1 - 0.00048 20.0 0.1 0.0012 18.7 0.0 1.7 2 0 0 2 2 2 1 Sec20 Syntaxin-18_N PF10496.9 EDP45220.1 - 0.0052 17.0 0.6 0.023 15.0 0.0 2.1 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Lipoprotein_X PF03305.13 EDP45220.1 - 0.074 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein CAF-1_p60_C PF15512.6 EDP45220.1 - 0.38 11.2 6.1 0.48 10.9 5.2 1.6 1 1 0 1 1 1 0 Chromatin assembly factor complex 1 subunit p60, C-terminal Methyltransf_25 PF13649.6 EDP45221.1 - 9.1e-12 45.5 0.1 2e-11 44.4 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EDP45221.1 - 2.3e-11 43.6 0.1 3.2e-11 43.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EDP45221.1 - 4.1e-11 42.9 0.1 7.1e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP45221.1 - 7.8e-10 38.8 0.0 2.4e-09 37.2 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP45221.1 - 1.1e-08 35.6 0.1 2.5e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EDP45221.1 - 5.4e-07 29.2 0.1 7.2e-07 28.8 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EDP45221.1 - 4.5e-06 27.3 0.0 9.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDP45221.1 - 5.6e-06 25.5 0.1 8.8e-06 24.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 EDP45221.1 - 9.4e-06 25.3 0.2 1.6e-05 24.5 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EDP45221.1 - 0.00049 19.9 0.1 0.0008 19.2 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EDP45221.1 - 0.00074 19.7 0.5 0.0015 18.7 0.4 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 EDP45221.1 - 0.0048 16.8 0.1 0.0093 15.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EDP45221.1 - 0.0089 15.8 0.1 0.013 15.2 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_24 PF13578.6 EDP45221.1 - 0.022 15.8 0.0 0.045 14.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EDP45221.1 - 0.043 13.8 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 EDP45221.1 - 0.048 13.1 0.3 0.12 11.7 0.3 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB Met_10 PF02475.16 EDP45221.1 - 0.059 13.1 1.0 0.15 11.8 0.3 1.8 1 1 0 2 2 2 0 Met-10+ like-protein Ubie_methyltran PF01209.18 EDP45221.1 - 0.08 12.3 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EDP45221.1 - 0.082 12.5 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PRMT5 PF05185.16 EDP45221.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Oxidored_q6 PF01058.22 EDP45222.1 - 4.3e-22 78.3 0.0 5e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Pkinase PF00069.25 EDP45223.1 - 1.9e-62 211.1 0.0 2.5e-62 210.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45223.1 - 3e-42 144.7 0.0 4.5e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP45223.1 - 3.7e-05 22.7 0.0 7.2e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EDP45223.1 - 0.001 18.5 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EDP45223.1 - 0.039 12.9 0.0 0.43 9.5 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 EDP45223.1 - 0.22 10.8 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CTP_transf_1 PF01148.20 EDP45224.1 - 1.7e-68 231.3 23.4 1.3e-63 215.3 14.1 2.3 2 0 0 2 2 2 2 Cytidylyltransferase family Acyl-CoA_dh_C PF12806.7 EDP45225.1 - 0.017 15.3 0.9 0.58 10.3 0.0 2.4 2 0 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like Pkinase PF00069.25 EDP45226.1 - 2.5e-58 197.5 0.0 1.6e-40 139.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45226.1 - 2.8e-25 89.1 0.0 4.9e-21 75.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EDP45226.1 - 6.8e-06 25.6 0.9 0.00017 21.1 0.0 2.7 4 0 0 4 4 4 1 Kinase-like APH PF01636.23 EDP45226.1 - 0.0004 20.4 1.0 0.0034 17.3 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 EDP45226.1 - 0.00044 19.9 0.0 0.15 11.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Response_reg PF00072.24 EDP45226.1 - 0.00062 19.9 0.8 0.0016 18.6 0.8 1.7 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EDP45226.1 - 0.056 13.7 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 PAS fold Seadorna_VP7 PF07387.11 EDP45226.1 - 0.068 12.2 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PAS_9 PF13426.7 EDP45226.1 - 0.12 12.6 0.0 0.62 10.3 0.0 2.1 2 0 0 2 2 2 0 PAS domain Kdo PF06293.14 EDP45226.1 - 0.13 11.6 0.0 0.36 10.1 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PRIMA1 PF16101.5 EDP45226.1 - 1 9.4 8.4 0.95 9.5 0.9 3.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 MFS_1 PF07690.16 EDP45227.1 - 2.4e-38 132.0 49.3 2.4e-38 132.0 49.3 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EDP45227.1 - 2.9e-15 56.1 8.7 2.9e-15 56.1 8.7 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EDP45227.1 - 4.9e-07 28.6 16.3 6.8e-07 28.1 15.5 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CIAPIN1 PF05093.13 EDP45228.1 - 1.1e-31 109.3 2.7 2.7e-31 108.0 2.7 1.7 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EDP45228.1 - 4.5e-06 26.9 0.0 7.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus LytR_C PF13399.6 EDP45228.1 - 0.1 13.6 0.1 0.24 12.4 0.1 1.7 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator PRCC PF10253.9 EDP45229.1 - 5.9e-11 43.6 7.7 5.9e-11 43.6 7.7 2.8 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting EMP24_GP25L PF01105.24 EDP45230.1 - 1.2e-20 74.2 0.0 1.2e-20 74.2 0.0 1.4 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD Ran_BP1 PF00638.18 EDP45231.1 - 1.3e-50 170.7 1.8 1.8e-50 170.3 1.8 1.1 1 0 0 1 1 1 1 RanBP1 domain Tau95 PF09734.9 EDP45232.1 - 4.4e-38 131.2 2.5 1e-37 130.1 2.5 1.6 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Pol_alpha_B_N PF08418.10 EDP45233.1 - 1.1e-12 48.4 0.0 1.5e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal Nop PF01798.18 EDP45234.1 - 8.1e-83 277.4 0.1 8.1e-83 277.4 0.1 1.8 2 0 0 2 2 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EDP45234.1 - 7e-15 55.2 0.2 7e-15 55.2 0.2 2.3 2 0 0 2 2 1 1 NOP5NT (NUC127) domain RR_TM4-6 PF06459.12 EDP45234.1 - 0.018 14.9 16.3 0.028 14.3 16.3 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YL1 PF05764.13 EDP45234.1 - 0.081 13.0 32.1 0.13 12.4 32.1 1.3 1 0 0 1 1 1 0 YL1 nuclear protein GAGA_bind PF06217.12 EDP45234.1 - 0.21 11.8 16.0 0.32 11.2 16.0 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Nop14 PF04147.12 EDP45234.1 - 0.26 9.5 26.0 0.33 9.1 26.0 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 EDP45234.1 - 1 9.4 48.3 1.9 8.5 48.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DDHD PF02862.17 EDP45234.1 - 2.4 8.3 7.6 5.2 7.2 7.6 1.6 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 EDP45234.1 - 3.1 6.7 13.4 4.4 6.2 13.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PTPRCAP PF15713.5 EDP45234.1 - 7 6.9 25.1 15 5.9 25.1 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Neur_chan_memb PF02932.16 EDP45234.1 - 7.2 6.6 6.2 11 6.1 6.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 EDP45234.1 - 8.3 4.6 32.7 16 3.6 31.4 1.9 2 0 0 2 2 2 0 CDC45-like protein Rhodanese PF00581.20 EDP45235.1 - 1.9e-10 41.2 0.0 2.6e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain PS_Dcarbxylase PF02666.15 EDP45237.1 - 3.6e-70 235.6 0.0 6.5e-68 228.2 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Nup88 PF10168.9 EDP45238.1 - 3.9e-29 101.0 0.5 1.8e-13 49.3 1.1 2.5 2 1 0 2 2 2 2 Nuclear pore component DUF948 PF06103.11 EDP45238.1 - 1.5 9.2 3.7 6.5 7.1 0.1 3.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) FYVE PF01363.21 EDP45239.1 - 1.4e-19 70.0 7.6 1.4e-19 70.0 7.6 2.8 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EDP45239.1 - 1.4e-08 34.9 6.1 1.4e-08 34.9 6.1 3.9 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 EDP45239.1 - 4.7e-05 23.1 5.5 4.7e-05 23.1 5.5 4.2 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EDP45239.1 - 7.9e-05 22.3 5.4 7.9e-05 22.3 5.4 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EDP45239.1 - 0.0056 16.9 7.2 0.0056 16.9 7.2 3.2 3 2 0 3 3 3 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EDP45239.1 - 0.021 14.9 4.3 0.021 14.9 4.3 3.5 4 0 0 4 4 4 0 RING-type zinc-finger zf-RING_5 PF14634.6 EDP45239.1 - 0.091 12.7 27.3 0.08 12.9 5.3 3.7 4 0 0 4 4 4 0 zinc-RING finger domain FYVE_2 PF02318.16 EDP45239.1 - 1.5 9.1 18.0 0.26 11.5 7.0 2.8 3 1 0 3 3 3 0 FYVE-type zinc finger Zn_ribbon_17 PF17120.5 EDP45239.1 - 5.4 6.7 20.3 0.12 12.0 5.5 3.3 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Ribosomal_L29e PF01779.17 EDP45240.1 - 3e-14 53.0 1.8 3.6e-11 43.2 0.6 2.2 2 0 0 2 2 2 2 Ribosomal L29e protein family Dimer_Tnp_hAT PF05699.14 EDP45240.1 - 0.033 14.0 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region MMM1 PF10296.9 EDP45241.1 - 3.1e-07 29.8 0.0 0.00032 19.9 0.0 2.5 2 1 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 TAP_C PF03943.13 EDP45243.1 - 1.4e-16 59.8 0.2 2.6e-16 59.0 0.2 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 EDP45243.1 - 1.5e-09 37.6 0.0 3.2e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EDP45243.1 - 1.3e-05 25.5 3.2 0.00033 21.0 1.4 3.2 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) NTF2 PF02136.20 EDP45243.1 - 1.9e-05 25.2 0.0 9.8e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_8 PF13855.6 EDP45243.1 - 0.0011 18.7 2.5 0.013 15.2 0.5 2.8 2 0 0 2 2 2 1 Leucine rich repeat CDCA PF18484.1 EDP45243.1 - 0.077 12.9 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Cadmium carbonic anhydrase repeat UBA_4 PF14555.6 EDP45243.1 - 0.14 12.0 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain MOR2-PAG1_N PF14222.6 EDP45244.1 - 3.8e-94 316.6 0.0 8.2e-94 315.5 0.0 1.6 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EDP45244.1 - 5.6e-53 180.4 1.1 5.6e-53 180.4 1.1 3.0 2 1 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EDP45244.1 - 1.5e-09 36.1 2.5 1.1e-05 23.4 0.1 2.5 3 0 0 3 3 3 2 Cell morphogenesis central region HEAT_2 PF13646.6 EDP45244.1 - 0.11 12.9 0.0 0.11 12.9 0.0 6.4 7 1 0 7 7 7 0 HEAT repeats GHMP_kinases_N PF00288.26 EDP45244.1 - 0.2 11.9 3.5 1.1 9.6 1.2 3.2 2 0 0 2 2 2 0 GHMP kinases N terminal domain HEAT PF02985.22 EDP45244.1 - 0.92 9.9 3.1 66 4.2 0.0 4.5 4 0 0 4 4 4 0 HEAT repeat NAD_binding_4 PF07993.12 EDP45245.1 - 3.6e-52 177.1 0.0 4.4e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EDP45245.1 - 3.6e-08 32.7 0.0 5.2e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EDP45245.1 - 0.00031 20.3 0.0 0.00049 19.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding PF00501.28 EDP45246.1 - 8.7e-73 245.3 0.0 1.1e-72 244.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EDP45246.1 - 4.6e-13 49.3 0.2 1.9e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site Condensation PF00668.20 EDP45246.1 - 1.4e-11 43.7 0.0 6.7e-05 21.7 0.0 2.9 2 1 0 2 2 2 2 Condensation domain AMP-binding_C PF13193.6 EDP45246.1 - 4.3e-05 24.4 0.2 0.0017 19.3 0.0 3.4 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain Tim17 PF02466.19 EDP45247.1 - 0.0043 17.4 1.8 0.007 16.7 1.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2717 PF10911.8 EDP45247.1 - 0.073 12.8 0.1 0.6 9.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) lci PF12197.8 EDP45247.1 - 3.3 7.6 6.1 1.3 8.9 0.2 2.3 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein COX6B PF02297.17 EDP45248.1 - 2.8e-23 81.9 1.3 5.7e-23 80.9 1.3 1.5 1 1 0 1 1 1 1 Cytochrome oxidase c subunit VIb XAP5 PF04921.14 EDP45249.1 - 1.6e-70 237.8 8.5 2.1e-70 237.4 8.5 1.1 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF2058 PF09831.9 EDP45249.1 - 0.61 10.2 10.1 0.82 9.8 4.7 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Sua5_yciO_yrdC PF01300.18 EDP45250.1 - 9.6e-50 168.6 0.0 1.6e-49 167.9 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EDP45250.1 - 8.8e-31 107.2 0.0 1.7e-30 106.4 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding AraC_N PF06719.13 EDP45250.1 - 0.0058 16.3 0.0 0.026 14.2 0.0 1.9 2 0 0 2 2 2 1 AraC-type transcriptional regulator N-terminus Pkinase PF00069.25 EDP45251.1 - 2.4e-69 233.7 0.0 4.4e-69 232.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45251.1 - 2e-31 109.3 0.0 1.7e-30 106.2 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EDP45251.1 - 4.1e-05 23.3 0.3 7.6e-05 22.4 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EDP45251.1 - 8e-05 22.1 0.1 0.29 10.4 0.0 3.2 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EDP45251.1 - 0.0047 16.9 0.5 1.4 8.8 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EDP45251.1 - 0.011 15.1 0.3 0.049 13.0 0.3 2.0 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EDP45251.1 - 0.048 12.4 0.0 0.081 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF4722 PF15849.5 EDP45252.1 - 0.0061 16.3 1.0 0.018 14.7 0.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4722) BCDHK_Adom3 PF10436.9 EDP45253.1 - 4.7e-28 98.1 3.3 8.4e-28 97.2 3.3 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EDP45253.1 - 0.00097 19.6 0.0 0.17 12.4 0.0 2.4 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SNARE PF05739.19 EDP45254.1 - 0.00078 19.4 0.4 0.0085 16.1 0.0 2.5 2 0 0 2 2 2 1 SNARE domain Gp_dh_N PF00044.24 EDP45254.1 - 0.051 13.9 0.0 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ISG65-75 PF11727.8 EDP45254.1 - 1.4 8.1 6.1 1.1 8.5 3.0 1.9 2 0 0 2 2 2 0 Invariant surface glycoprotein TipAS PF07739.13 EDP45254.1 - 1.7 9.2 7.1 0.57 10.7 2.0 2.1 1 1 0 2 2 2 0 TipAS antibiotic-recognition domain THOC7 PF05615.13 EDP45254.1 - 1.7 8.9 14.7 0.32 11.3 8.0 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 DUF745 PF05335.13 EDP45254.1 - 4 7.1 16.2 0.23 11.2 8.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF2203 PF09969.9 EDP45254.1 - 4.7 7.9 6.3 5.1 7.8 1.6 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) WBS_methylT PF12589.8 EDP45255.1 - 4.2e-14 53.1 7.4 1.9e-09 38.1 1.6 2.4 2 0 0 2 2 2 2 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EDP45255.1 - 4.3e-10 40.1 0.0 1.1e-09 38.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EDP45255.1 - 8.1e-09 36.1 0.0 2.2e-08 34.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EDP45255.1 - 8.1e-06 25.8 0.0 2.1e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP45255.1 - 8e-05 23.3 0.0 0.00049 20.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP45255.1 - 0.001 18.9 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 EDP45255.1 - 0.0095 15.7 0.0 0.047 13.4 0.0 1.9 2 0 0 2 2 2 1 DNA methylase AdoMet_MTase PF07757.13 EDP45255.1 - 0.045 14.1 0.0 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase PCMT PF01135.19 EDP45255.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EDP45255.1 - 0.2 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Orai-1 PF07856.12 EDP45256.1 - 0.18 11.5 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Mediator of CRAC channel activity TPR_2 PF07719.17 EDP45257.1 - 8.1e-13 47.4 11.9 0.2 11.9 0.0 10.4 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 EDP45257.1 - 1.6e-11 43.5 8.8 0.033 14.0 0.0 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_8 PF13181.6 EDP45257.1 - 3.3e-10 39.3 6.1 0.38 11.1 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP45257.1 - 8.3e-10 38.8 15.2 0.0011 19.3 0.1 6.7 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EDP45257.1 - 8.6e-07 29.2 17.4 1.1 10.0 0.0 9.9 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDP45257.1 - 2e-06 28.2 26.6 4.5e-05 23.9 1.4 7.9 7 2 1 9 9 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EDP45257.1 - 3.4e-06 27.4 31.1 0.89 10.5 0.4 11.0 12 2 3 15 15 12 2 Tetratricopeptide repeat TPR_16 PF13432.6 EDP45257.1 - 0.00022 21.8 15.0 2 9.1 0.0 6.8 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDP45257.1 - 0.0011 18.8 10.5 1.9 8.7 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EDP45257.1 - 0.0039 17.0 21.4 0.62 10.0 0.6 7.3 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP45257.1 - 0.0076 16.6 0.2 2.1e+02 2.6 0.0 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EDP45257.1 - 0.013 15.6 12.4 3.9 7.7 0.4 6.8 6 1 2 8 8 8 0 Tetratricopeptide repeat TPR_4 PF07721.14 EDP45257.1 - 0.074 13.7 0.0 24 5.9 0.0 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP45257.1 - 0.082 13.1 6.3 0.91 9.8 0.1 5.2 7 1 1 8 8 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EDP45257.1 - 0.098 13.0 3.0 35 4.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 EDP45258.1 - 2.6e-80 270.2 0.0 3.4e-80 269.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Acid_PPase PF12689.7 EDP45259.1 - 1.4e-14 54.3 0.0 1.5e-14 54.2 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase Pex2_Pex12 PF04757.14 EDP45260.1 - 5.4e-30 104.7 10.1 7.9e-30 104.1 10.1 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region RIX1 PF08167.12 EDP45261.1 - 2.2e-15 56.9 0.2 5.9e-15 55.5 0.1 1.8 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Sec10 PF07393.11 EDP45262.1 - 1.1e-218 728.2 0.0 1.3e-218 728.0 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 Minor_tail_Z PF06763.11 EDP45262.1 - 0.12 12.2 0.3 0.3 10.8 0.3 1.6 1 0 0 1 1 1 0 Prophage minor tail protein Z (GPZ) Imm-NTF2 PF15655.6 EDP45262.1 - 0.16 12.2 0.0 2.2 8.6 0.0 2.4 1 1 0 1 1 1 0 NTF2 fold immunity protein MbeD_MobD PF04899.12 EDP45262.1 - 0.77 9.9 4.0 36 4.6 1.5 3.5 3 0 0 3 3 3 0 MbeD/MobD like FAM184 PF15665.5 EDP45262.1 - 3.1 7.5 4.3 0.61 9.8 0.5 1.7 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B HK PF02110.15 EDP45264.1 - 2.6e-69 233.3 0.3 1.1e-65 221.4 0.6 2.1 2 0 0 2 2 2 2 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EDP45264.1 - 3.1e-40 137.4 0.0 6.8e-40 136.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 EDP45264.1 - 0.0088 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EDP45264.1 - 0.075 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 pfkB family carbohydrate kinase RNA_pol_Rpb4 PF03874.16 EDP45265.1 - 3.8e-24 85.4 0.1 6.2e-24 84.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 HCO3_cotransp PF00955.21 EDP45266.1 - 1.2e-62 212.4 17.0 5.6e-33 114.5 3.4 3.1 2 1 1 3 3 3 3 HCO3- transporter family DUF423 PF04241.15 EDP45266.1 - 1.4 9.2 5.4 0.59 10.4 1.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Peptidase_M20 PF01546.28 EDP45267.1 - 6.1e-26 91.4 0.0 4.2e-25 88.7 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EDP45267.1 - 1.4e-11 44.3 0.0 2.7e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EDP45267.1 - 0.00085 19.1 0.0 0.0019 17.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 DUF4392 PF14336.6 EDP45267.1 - 0.045 13.2 0.0 0.076 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) Spc7 PF08317.11 EDP45268.1 - 0.00044 19.2 10.9 0.00044 19.2 10.9 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein FapA PF03961.13 EDP45268.1 - 0.14 10.8 2.3 0.23 10.0 2.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 EDP45268.1 - 3.2 5.6 5.7 4.9 5.0 5.7 1.1 1 0 0 1 1 1 0 Prominin ProSAAS PF07259.12 EDP45268.1 - 4.5 7.2 9.2 0.099 12.6 0.4 2.6 2 0 0 2 2 2 0 ProSAAS precursor COG2 PF06148.11 EDP45268.1 - 5.6 7.1 7.5 15 5.6 7.5 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 EDP45268.1 - 8.3 6.5 8.3 7.4 6.6 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) eRF1_1 PF03463.15 EDP45269.1 - 1.5e-54 183.4 0.0 2.8e-54 182.6 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EDP45269.1 - 1.7e-18 67.1 0.0 3.2e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EDP45269.1 - 7.2e-17 62.0 0.0 1.5e-16 60.9 0.0 1.5 2 0 0 2 2 2 1 eRF1 domain 2 AD PF09793.9 EDP45270.1 - 3e-13 49.7 0.0 5.7e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain P22_portal PF16510.5 EDP45270.1 - 0.039 12.5 0.1 0.37 9.4 0.0 1.9 1 1 1 2 2 2 0 Phage P22-like portal protein Cactin_mid PF10312.9 EDP45271.1 - 2.4e-54 184.1 1.8 2.4e-54 184.1 1.8 1.9 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EDP45271.1 - 1.3e-52 177.0 1.8 2.3e-52 176.2 1.8 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DnaJ_CXXCXGXG PF00684.19 EDP45272.1 - 0.0095 16.3 0.5 0.018 15.4 0.5 1.5 1 0 0 1 1 1 1 DnaJ central domain Prim_Zn_Ribbon PF08273.12 EDP45272.1 - 0.022 15.0 5.3 0.54 10.6 1.0 2.3 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Anti-TRAP PF15777.5 EDP45272.1 - 0.077 13.0 1.1 0.16 12.0 1.1 1.5 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Lir1 PF07207.11 EDP45272.1 - 0.091 13.0 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Light regulated protein Lir1 Amidohydro_2 PF04909.14 EDP45273.1 - 1.4e-07 31.6 0.3 2e-07 31.1 0.3 1.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 EDP45273.1 - 8.2e-05 22.1 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family ICMT PF04140.14 EDP45274.1 - 2.4e-24 85.5 0.5 4e-24 84.9 0.5 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EDP45274.1 - 5.6e-11 42.8 1.1 5.6e-11 42.8 1.1 1.5 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EDP45274.1 - 0.00017 21.2 0.9 0.0002 21.0 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 EDP45274.1 - 0.00069 18.5 0.1 0.001 17.9 0.1 1.3 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family NnrU PF07298.11 EDP45274.1 - 0.0025 17.4 8.1 0.0039 16.7 8.1 1.4 1 1 0 1 1 1 1 NnrU protein Kinesin PF00225.23 EDP45275.1 - 1.4e-79 267.5 0.4 1.9e-79 267.0 0.4 1.2 1 0 0 1 1 1 1 Kinesin motor domain Atg14 PF10186.9 EDP45275.1 - 0.0084 15.2 0.6 0.014 14.5 0.6 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 EDP45275.1 - 0.063 13.7 0.6 0.16 12.5 0.6 1.6 1 0 0 1 1 1 0 Cell division protein ZapB GPS2_interact PF15784.5 EDP45275.1 - 0.077 13.4 0.1 0.31 11.5 0.1 2.1 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain ABC_tran_CTD PF16326.5 EDP45275.1 - 0.46 10.8 2.4 1.3 9.3 2.4 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain Nup160 PF11715.8 EDP45276.1 - 6.8e-45 153.7 1.6 3e-41 141.7 0.1 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 JAB PF01398.21 EDP45277.1 - 2.2e-33 114.7 0.0 4.2e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EDP45277.1 - 3e-13 50.2 1.1 4.6e-13 49.6 0.5 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EDP45277.1 - 3e-07 30.2 0.0 5.1e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 EDP45277.1 - 0.00014 21.9 0.1 0.00027 21.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5624) UPF0172 PF03665.13 EDP45277.1 - 0.018 15.1 0.1 0.044 13.8 0.1 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) MbeB_N PF04837.12 EDP45277.1 - 0.054 13.8 0.3 0.14 12.5 0.1 1.8 1 1 0 1 1 1 0 MbeB-like, N-term conserved region Hist_deacetyl PF00850.19 EDP45281.1 - 2e-76 257.4 0.1 2.8e-76 256.9 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 EDP45281.1 - 1.3e-25 90.1 0.0 2e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Arb2 domain DEP PF00610.21 EDP45282.1 - 0.00014 21.9 0.2 0.012 15.7 0.1 2.5 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G10 PF01125.17 EDP45283.1 - 4.3e-49 166.1 0.6 4.9e-49 165.9 0.6 1.1 1 0 0 1 1 1 1 G10 protein Lum_binding PF00677.17 EDP45284.1 - 1.5e-39 133.9 0.0 7.9e-19 67.4 0.0 2.2 2 0 0 2 2 2 2 Lumazine binding domain LRR_4 PF12799.7 EDP45285.1 - 4.2e-33 112.8 1.4 2e-05 24.9 0.0 8.1 6 1 3 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EDP45285.1 - 3.5e-19 68.3 10.2 0.00075 19.2 0.1 7.9 8 2 2 10 10 10 6 Leucine rich repeat LRR_9 PF14580.6 EDP45285.1 - 1.7e-07 30.9 0.6 0.33 10.4 0.1 3.6 1 1 1 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EDP45285.1 - 1.4e-05 24.7 5.2 7.4 6.9 0.1 7.5 8 0 0 8 8 8 2 Leucine Rich repeat MAP65_ASE1 PF03999.12 EDP45286.1 - 1.4e-63 215.6 1.2 4.3e-54 184.3 0.0 3.1 2 1 1 3 3 3 3 Microtubule associated protein (MAP65/ASE1 family) AIP3 PF03915.13 EDP45286.1 - 0.12 11.4 4.5 0.091 11.8 0.8 2.4 2 1 0 2 2 2 0 Actin interacting protein 3 MIP-T3_C PF17749.1 EDP45286.1 - 0.21 11.6 2.5 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region Phage_int_SAM_2 PF12834.7 EDP45286.1 - 2.7 8.7 4.6 13 6.5 0.1 2.8 3 0 0 3 3 3 0 Phage integrase, N-terminal Vps52 PF04129.12 EDP45287.1 - 1.6e-32 112.9 0.5 2e-30 106.0 0.2 2.7 2 1 0 2 2 2 1 Vps52 / Sac2 family COG6 PF06419.11 EDP45287.1 - 0.00069 18.0 0.0 0.00098 17.5 0.0 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Spc7 PF08317.11 EDP45287.1 - 0.029 13.3 0.1 0.049 12.5 0.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EDP45287.1 - 0.03 14.3 0.2 0.063 13.3 0.2 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.9 EDP45287.1 - 0.038 13.4 0.2 0.065 12.7 0.2 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 PI3K_P85_iSH2 PF16454.5 EDP45287.1 - 0.043 13.4 0.1 0.076 12.6 0.1 1.5 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain USP8_interact PF08941.10 EDP45287.1 - 0.081 12.7 0.1 0.21 11.4 0.1 1.7 1 1 0 1 1 1 0 USP8 interacting ADIP PF11559.8 EDP45287.1 - 0.089 12.9 2.0 0.18 11.9 2.0 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Laminin_II PF06009.12 EDP45287.1 - 0.14 12.2 1.7 0.86 9.6 0.4 2.4 1 1 1 2 2 2 0 Laminin Domain II IPK PF03770.16 EDP45288.1 - 4.2e-30 105.1 0.0 5.7e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase zf-H2C2_2 PF13465.6 EDP45289.1 - 5.6e-34 115.1 32.7 2.6e-09 37.1 0.7 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 EDP45289.1 - 7.8e-27 92.2 37.7 8.8e-06 25.9 0.7 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP45289.1 - 5.7e-18 64.1 38.2 0.00027 21.5 2.2 6.7 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EDP45289.1 - 2e-08 34.3 12.9 0.0034 17.6 0.2 5.5 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EDP45289.1 - 3.9e-07 30.3 16.5 0.00088 19.5 3.5 3.7 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EDP45289.1 - 5.1e-07 29.5 22.6 0.0095 15.9 2.1 5.1 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 EDP45289.1 - 3.5e-06 27.6 24.5 0.38 11.4 0.1 6.5 3 2 3 6 6 6 3 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EDP45289.1 - 0.00035 20.8 9.1 0.092 12.9 0.3 3.5 2 1 2 4 4 4 2 Aberrant zinc-finger zf-C2H2_9 PF16293.5 EDP45289.1 - 0.0014 18.5 7.1 0.17 11.8 0.1 4.3 4 0 0 4 4 4 1 C2H2 type zinc-finger (1 copy) zf-met PF12874.7 EDP45289.1 - 0.0024 18.2 10.6 1.1 9.8 0.8 4.7 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EDP45289.1 - 0.0039 17.5 0.9 0.0039 17.5 0.9 3.6 2 1 1 4 4 4 1 C2H2 type zinc-finger (2 copies) IBR PF01485.21 EDP45289.1 - 0.024 14.8 1.9 0.024 14.8 1.9 4.0 3 2 1 4 4 4 0 IBR domain, a half RING-finger domain zf-Di19 PF05605.12 EDP45289.1 - 0.06 13.7 23.1 0.082 13.2 2.2 4.3 1 1 4 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding DUF4863 PF16155.5 EDP45289.1 - 0.088 12.7 0.1 0.17 11.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4863) zf_UBZ PF18439.1 EDP45289.1 - 0.16 11.6 8.2 0.69 9.6 0.4 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-RING_7 PF02591.15 EDP45289.1 - 0.19 11.9 3.2 1.7 8.9 0.2 2.9 3 0 0 3 3 2 0 C4-type zinc ribbon domain zf-C2HC_2 PF13913.6 EDP45289.1 - 0.25 11.3 19.0 0.55 10.2 1.1 4.8 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EDP45289.1 - 0.33 10.7 10.3 0.49 10.2 0.1 4.4 5 0 0 5 5 5 0 zinc-finger C2H2-type zinc_ribbon_9 PF14369.6 EDP45289.1 - 0.46 10.8 10.3 6.9 7.0 0.2 4.1 4 0 0 4 4 3 0 zinc-ribbon zf-AN1 PF01428.16 EDP45289.1 - 1.8 8.8 13.2 16 5.8 0.1 4.6 3 1 1 4 4 4 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 EDP45289.1 - 2.6 8.2 14.7 5.9 7.1 0.5 4.0 2 2 2 4 4 4 0 Zinc ribbon domain zf_C2H2_ZHX PF18387.1 EDP45289.1 - 2.7 7.7 10.5 0.37 10.5 0.9 3.3 3 1 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2225 PF09986.9 EDP45289.1 - 4.2 7.0 9.1 2.3 7.9 0.7 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) zf_ZIC PF18366.1 EDP45289.1 - 7.3 6.8 17.7 3.7 7.7 1.5 5.3 2 1 3 5 5 5 0 Zic proteins zinc finger domain Lipase_3 PF01764.25 EDP45290.1 - 4e-16 59.2 0.0 1.2e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 EDP45290.1 - 0.032 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EDP45290.1 - 0.047 14.3 0.2 0.047 14.3 0.2 2.7 2 1 0 2 2 2 0 Alpha/beta hydrolase family Importin_rep_4 PF18808.1 EDP45290.1 - 0.19 12.1 0.6 1.1 9.6 0.5 2.2 2 0 0 2 2 2 0 Importin repeat Ribosomal_S13_N PF08069.12 EDP45291.1 - 2.4e-30 104.3 0.7 4e-30 103.6 0.7 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EDP45291.1 - 4.9e-14 52.3 0.2 7.5e-14 51.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EDP45291.1 - 0.00037 20.4 0.3 0.0019 18.1 0.1 2.0 1 1 0 2 2 2 1 'Paired box' domain HTH_32 PF13565.6 EDP45291.1 - 0.04 14.5 0.1 0.09 13.4 0.1 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Ribosomal_S6e PF01092.19 EDP45292.1 - 1.4e-54 183.3 0.0 2.3e-54 182.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S6e Sbi-IV PF11621.8 EDP45292.1 - 0.093 13.1 1.9 0.2 12.0 1.9 1.6 1 0 0 1 1 1 0 C3 binding domain 4 of IgG-bind protein SBI Tri3 PF07428.11 EDP45293.1 - 0.00058 18.9 0.0 0.0018 17.3 0.0 1.7 1 1 0 1 1 1 1 15-O-acetyltransferase Tri3 Pkinase PF00069.25 EDP45294.1 - 2.8e-42 144.9 0.0 1.1e-27 97.0 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45294.1 - 3.9e-19 69.0 0.0 1.4e-12 47.5 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase SNF2_N PF00176.23 EDP45295.1 - 2.2e-70 237.1 0.0 3.4e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EDP45295.1 - 4.4e-08 33.4 0.0 1.7e-07 31.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EDP45295.1 - 7.2e-07 29.4 0.0 6.6e-06 26.2 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 EDP45295.1 - 0.0012 18.8 7.4 0.0028 17.6 7.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDP45295.1 - 0.0098 15.7 8.2 0.023 14.5 8.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EDP45295.1 - 0.013 15.4 7.6 0.029 14.2 7.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EDP45295.1 - 0.15 11.9 7.5 0.45 10.4 7.5 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EDP45295.1 - 0.49 10.8 8.9 1.4 9.3 8.9 1.9 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 EDP45295.1 - 4.2 7.5 9.1 0.31 11.1 2.1 2.7 3 0 0 3 3 3 0 RING-type zinc-finger Peptidase_S10 PF00450.22 EDP45296.1 - 1.4e-102 344.2 0.0 1.8e-102 343.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Xpo1 PF08389.12 EDP45297.1 - 0.12 12.4 0.0 0.85 9.7 0.0 2.6 2 0 0 2 2 2 0 Exportin 1-like protein DAG_kinase_N PF14513.6 EDP45299.1 - 0.14 12.4 0.1 0.32 11.2 0.1 1.7 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus UQ_con PF00179.26 EDP45300.1 - 3.5e-22 78.5 0.0 7.3e-22 77.5 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme PMSR PF01625.21 EDP45301.1 - 6.3e-57 192.0 0.3 7.5e-57 191.8 0.3 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase HbrB PF08539.11 EDP45302.1 - 1.3e-50 171.6 0.0 4.1e-50 170.1 0.0 1.8 1 1 0 1 1 1 1 HbrB-like MCR_gamma PF02240.16 EDP45302.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit ApbA_C PF08546.11 EDP45303.1 - 3.1e-21 75.8 0.0 5.9e-21 75.0 0.0 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EDP45303.1 - 0.0012 18.4 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Methyltr_RsmB-F PF01189.17 EDP45304.1 - 5.7e-25 88.1 0.0 8.2e-24 84.4 0.0 2.6 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EDP45304.1 - 1.2e-05 25.5 0.0 2.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EDP45304.1 - 0.085 12.4 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain BcrAD_BadFG PF01869.20 EDP45305.1 - 2.1e-23 83.2 0.5 2.5e-23 82.9 0.5 1.1 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 EDP45305.1 - 0.00017 21.2 0.5 0.45 9.9 0.2 2.2 2 0 0 2 2 2 2 ROK family Hydant_A_N PF05378.13 EDP45305.1 - 0.33 10.6 1.8 1.9 8.2 1.0 2.6 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region RhoGEF PF00621.20 EDP45306.1 - 1.8e-22 80.5 0.0 2.8e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EDP45306.1 - 0.0019 18.7 0.0 0.0045 17.5 0.0 1.6 1 0 0 1 1 1 1 PH domain Adap_comp_sub PF00928.21 EDP45307.1 - 6.4e-91 304.4 0.2 1.1e-90 303.6 0.1 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EDP45307.1 - 3e-07 30.4 0.0 5.2e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EDP45307.1 - 0.024 14.1 0.1 0.055 12.9 0.0 1.6 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain LisH PF08513.11 EDP45308.1 - 0.0076 16.2 0.2 0.015 15.3 0.2 1.5 1 0 0 1 1 1 1 LisH Sin_N PF04801.13 EDP45309.1 - 1.7 7.8 29.3 0.49 9.6 21.8 2.4 2 0 0 2 2 2 0 Sin-like protein conserved region DUF2072 PF09845.9 EDP45309.1 - 5.1 7.4 7.3 12 6.2 7.3 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein Ribosomal_L18 PF17135.4 EDP45310.1 - 2.9e-63 212.6 0.6 3.3e-63 212.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EDP45310.1 - 0.00065 20.4 0.9 0.00079 20.1 0.0 1.7 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RRM_1 PF00076.22 EDP45311.1 - 1.1e-16 60.4 0.0 1.8e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EDP45311.1 - 0.00072 19.2 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EDP45311.1 - 0.011 15.5 0.2 0.32 10.9 0.0 2.8 2 1 0 2 2 2 0 Occluded RNA-recognition motif Iso_dh PF00180.20 EDP45312.1 - 3.6e-101 338.8 0.0 4.5e-101 338.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 EDP45313.1 - 5.8e-81 272.3 0.0 6.5e-81 272.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Cupin_8 PF13621.6 EDP45314.1 - 2.1e-30 106.3 0.2 3.6e-30 105.5 0.2 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EDP45314.1 - 0.0015 18.1 0.1 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 EDP45314.1 - 0.0036 17.7 0.6 0.63 10.5 0.6 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 EDP45314.1 - 0.088 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Cupin Histone_H2A_C PF16211.5 EDP45315.1 - 9.3e-19 66.9 0.9 1.7e-18 66.1 0.9 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EDP45315.1 - 5.7e-18 65.6 0.0 7.3e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDP45315.1 - 2.5e-05 24.5 0.0 3.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EDP45316.1 - 3.4e-24 85.7 1.0 4.5e-24 85.3 1.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EDP45316.1 - 6.8e-07 29.5 0.1 1.3e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EDP45316.1 - 0.0005 20.5 0.0 0.00081 19.8 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EDP45316.1 - 0.038 13.6 0.3 0.18 11.5 0.3 1.8 1 1 0 1 1 1 0 Replication protein C N-terminal domain NFACT-R_2 PF18297.1 EDP45316.1 - 0.038 14.2 0.7 0.047 13.9 0.1 1.5 2 0 0 2 2 2 0 NFACT protein RNA binding domain CENP-W PF15510.6 EDP45316.1 - 0.043 14.0 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 CENP-W protein DUF1018 PF06252.12 EDP45316.1 - 0.057 14.4 0.4 0.086 13.8 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) Bt_P21 PF05560.11 EDP45316.1 - 0.091 12.4 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein YscO-like PF16789.5 EDP45316.1 - 0.095 12.7 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein Snf7 PF03357.21 EDP45317.1 - 7.9e-11 41.8 7.9 9.5e-11 41.6 7.9 1.0 1 0 0 1 1 1 1 Snf7 LUC7 PF03194.15 EDP45317.1 - 0.00037 20.2 2.1 0.00046 19.9 2.1 1.0 1 0 0 1 1 1 1 LUC7 N_terminus IMD PF08397.11 EDP45317.1 - 0.088 12.2 3.3 0.11 11.8 3.3 1.2 1 1 0 1 1 1 0 IRSp53/MIM homology domain HlyD_2 PF12700.7 EDP45317.1 - 0.093 11.4 0.9 0.11 11.1 0.9 1.0 1 0 0 1 1 1 0 HlyD family secretion protein RED_C PF07807.11 EDP45317.1 - 0.2 12.1 1.7 0.16 12.5 0.5 1.5 2 0 0 2 2 2 0 RED-like protein C-terminal region Cyclin_N PF00134.23 EDP45318.1 - 0.033 13.9 0.0 0.34 10.7 0.0 2.2 1 1 0 1 1 1 0 Cyclin, N-terminal domain Bac_GDH PF05088.12 EDP45318.1 - 0.14 9.6 0.0 0.17 9.3 0.0 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Tfb4 PF03850.14 EDP45319.1 - 1e-29 103.9 0.0 1.3e-29 103.6 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 Pkinase PF00069.25 EDP45320.1 - 5.2e-35 121.1 0.0 1.7e-23 83.3 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45320.1 - 8.9e-19 67.8 0.0 1.8e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EDP45320.1 - 0.094 11.5 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EDP45320.1 - 0.21 10.8 0.0 0.59 9.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like p450 PF00067.22 EDP45321.1 - 6.3e-51 173.6 0.0 8.3e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DASH_Duo1 PF08651.10 EDP45321.1 - 0.051 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 DASH complex subunit Duo1 Glucan_synthase PF02364.15 EDP45322.1 - 1.9e-285 949.2 0.0 3.6e-285 948.3 0.0 1.4 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EDP45322.1 - 1.1e-40 139.0 0.2 3.3e-40 137.4 0.2 1.9 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glucan_synthase PF02364.15 EDP45323.1 - 3.4e-47 161.2 1.8 1.3e-46 159.2 0.1 2.0 2 0 0 2 2 2 2 1,3-beta-glucan synthase component KilA-N PF04383.13 EDP45324.1 - 0.0027 17.5 0.0 0.0047 16.8 0.0 1.3 1 0 0 1 1 1 1 KilA-N domain LIM PF00412.22 EDP45325.1 - 4.5e-16 58.8 11.2 1.4e-09 38.1 3.2 2.5 2 0 0 2 2 2 2 LIM domain PRIMA1 PF16101.5 EDP45325.1 - 0.1 12.7 1.6 0.23 11.5 1.6 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DZR PF12773.7 EDP45325.1 - 0.16 12.1 8.1 1.8 8.6 6.9 2.5 1 1 1 2 2 2 0 Double zinc ribbon VATC PF18716.1 EDP45325.1 - 1.4 8.8 7.5 0.38 10.6 1.3 2.8 3 0 0 3 3 3 0 Vms1-associating treble clef domain zf-C2H2 PF00096.26 EDP45326.1 - 2.1e-07 31.0 11.7 0.0011 19.3 1.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EDP45326.1 - 1.1e-05 25.8 10.0 0.017 15.9 0.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EDP45326.1 - 1.2 9.2 6.7 0.74 9.9 1.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EDP45326.1 - 5.9 7.4 5.9 28 5.3 1.6 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 EDP45326.1 - 8.9 6.9 12.1 0.89 10.1 2.3 2.8 3 0 0 3 3 3 0 Zinc-finger double domain Iwr1 PF08574.10 EDP45327.1 - 3.8e-09 37.4 1.8 4.5e-09 37.2 1.8 1.3 1 0 0 1 1 1 1 Transcription factor Iwr1 Rhomboid PF01694.22 EDP45328.1 - 3e-27 95.4 11.5 3e-27 95.4 11.5 2.1 2 1 0 2 2 2 1 Rhomboid family PQ-loop PF04193.14 EDP45329.1 - 4.5e-38 128.8 10.7 7.9e-20 70.4 1.4 2.5 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EDP45329.1 - 0.024 14.6 5.9 0.15 12.1 0.4 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange HEM4 PF02602.15 EDP45330.1 - 7.7e-26 90.9 0.0 7.5e-25 87.6 0.0 2.0 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Citrate_synt PF00285.21 EDP45331.1 - 1.2e-91 307.6 0.0 1.5e-91 307.2 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PLDc_2 PF13091.6 EDP45332.1 - 1e-11 44.9 0.0 1.1e-05 25.3 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EDP45332.1 - 1.2e-11 44.3 0.1 0.0002 21.4 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PX PF00787.24 EDP45332.1 - 1.1e-07 31.8 0.3 2.3e-07 30.8 0.3 1.6 1 0 0 1 1 1 1 PX domain PH PF00169.29 EDP45332.1 - 0.011 16.3 0.2 0.023 15.2 0.2 1.6 1 0 0 1 1 1 0 PH domain Meis_PKNOX_N PF16493.5 EDP45332.1 - 0.16 12.3 0.2 2.3 8.6 0.0 2.4 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 AAA PF00004.29 EDP45333.1 - 6.1e-41 139.9 0.0 1.2e-40 139.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EDP45333.1 - 7.4e-27 93.1 0.0 3.8e-26 90.8 0.0 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EDP45333.1 - 2.5e-10 40.0 0.0 1.7e-09 37.3 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 EDP45333.1 - 6.7e-06 26.1 0.0 2.2e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EDP45333.1 - 1.2e-05 25.6 0.9 0.012 15.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EDP45333.1 - 2.5e-05 24.7 2.3 0.0018 18.7 0.0 3.0 2 1 0 3 3 2 1 AAA ATPase domain MIT PF04212.18 EDP45333.1 - 3.4e-05 23.8 1.2 7.4e-05 22.7 1.2 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 EDP45333.1 - 5.6e-05 22.9 0.0 9.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EDP45333.1 - 0.00016 21.5 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EDP45333.1 - 0.00039 20.5 0.0 0.00092 19.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EDP45333.1 - 0.00095 19.3 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EDP45333.1 - 0.0014 19.2 0.6 0.0072 16.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EDP45333.1 - 0.0017 18.1 0.0 0.074 12.7 0.0 2.6 1 1 0 1 1 1 1 Sigma-54 interaction domain TIP49 PF06068.13 EDP45333.1 - 0.0018 17.6 0.0 0.0032 16.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EDP45333.1 - 0.0028 16.8 0.0 0.0042 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EDP45333.1 - 0.0034 17.8 0.4 0.015 15.7 0.0 2.4 3 0 0 3 3 1 1 RNA helicase AAA_33 PF13671.6 EDP45333.1 - 0.0042 17.3 0.0 0.0042 17.3 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EDP45333.1 - 0.0043 16.8 0.1 0.58 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EDP45333.1 - 0.0089 15.6 4.9 0.11 12.0 0.1 2.9 2 1 1 3 3 3 1 AAA domain AAA_24 PF13479.6 EDP45333.1 - 0.015 15.0 0.8 0.051 13.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EDP45333.1 - 0.02 14.3 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EDP45333.1 - 0.03 13.7 2.4 1.9 7.8 0.0 2.7 2 1 1 3 3 3 0 KaiC AAA_17 PF13207.6 EDP45333.1 - 0.036 14.5 3.6 0.042 14.3 0.0 2.5 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 EDP45333.1 - 0.043 13.2 0.0 6.8 6.1 0.0 2.6 1 1 1 2 2 2 0 Bacterial TniB protein NB-ARC PF00931.22 EDP45333.1 - 0.065 12.4 0.3 3 7.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.18 EDP45333.1 - 0.072 12.8 0.0 2.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EDP45333.1 - 0.08 12.4 0.0 0.26 10.8 0.0 1.9 2 0 0 2 2 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EDP45333.1 - 0.085 13.0 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EDP45333.1 - 0.091 13.3 0.2 1.4 9.4 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 EDP45333.1 - 0.091 12.5 3.2 1.8 8.4 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 EDP45333.1 - 0.095 12.6 0.0 1.7 8.5 0.0 2.3 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea Torsin PF06309.11 EDP45333.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Torsin PhoH PF02562.16 EDP45333.1 - 0.15 11.5 0.0 0.46 9.9 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein DUF2791 PF10923.8 EDP45333.1 - 0.15 10.9 0.1 10 4.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) CPT PF07931.12 EDP45333.1 - 0.2 11.5 0.0 0.2 11.5 0.0 2.2 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 EDP45333.1 - 0.55 10.5 0.0 0.55 10.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain Cytidylate_kin PF02224.18 EDP45333.1 - 0.55 9.9 0.1 0.55 9.9 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase Xpo1 PF08389.12 EDP45334.1 - 3.9e-24 85.4 0.0 1.6e-23 83.4 0.0 2.2 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EDP45334.1 - 1.1e-06 28.5 0.7 2.5e-06 27.3 0.7 1.6 1 0 0 1 1 1 1 Importin-beta N-terminal domain RTP1_C1 PF10363.9 EDP45334.1 - 0.0033 17.6 0.1 0.061 13.5 0.0 3.2 3 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 ParcG PF10274.9 EDP45334.1 - 0.013 15.7 0.0 0.99 9.5 0.0 2.5 2 0 0 2 2 2 0 Parkin co-regulated protein Importin_rep PF18773.1 EDP45334.1 - 0.053 13.2 0.2 0.099 12.4 0.2 1.5 1 0 0 1 1 1 0 Importin 13 repeat ERAP1_C PF11838.8 EDP45334.1 - 0.19 11.3 3.3 14 5.1 0.3 4.0 2 1 1 3 3 3 0 ERAP1-like C-terminal domain Pkinase PF00069.25 EDP45335.1 - 4.7e-66 222.8 0.0 6.4e-66 222.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45335.1 - 6.4e-44 150.2 0.0 9.2e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP45335.1 - 5.7e-09 35.7 0.0 9.4e-06 25.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Ras_bdg_2 PF14847.6 EDP45335.1 - 0.00085 19.6 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 Ras-binding domain of Byr2 APH PF01636.23 EDP45335.1 - 0.0092 15.9 0.0 0.081 12.8 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EDP45335.1 - 0.017 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EDP45335.1 - 0.021 13.9 0.0 0.032 13.3 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EDP45335.1 - 0.043 12.6 0.0 0.075 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RA PF00788.23 EDP45335.1 - 0.12 13.0 0.0 0.29 11.8 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain FTA2 PF13095.6 EDP45335.1 - 0.18 11.4 0.0 0.45 10.1 0.0 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 UQ_con PF00179.26 EDP45336.1 - 1.2e-40 138.4 0.0 1.4e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EDP45336.1 - 0.0045 16.8 0.2 0.007 16.2 0.2 1.3 1 0 0 1 1 1 1 UEV domain UFC1 PF08694.11 EDP45336.1 - 0.0057 16.3 0.0 0.0071 16.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 EDP45336.1 - 0.046 14.0 0.0 0.053 13.8 0.0 1.2 1 0 0 1 1 1 0 RWD domain Ras PF00071.22 EDP45337.1 - 3.8e-62 208.7 0.1 4.6e-62 208.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP45337.1 - 6.3e-34 116.8 0.1 9.9e-34 116.1 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP45337.1 - 1.1e-12 47.7 0.0 1.5e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EDP45337.1 - 3.3e-06 27.1 0.1 4.7e-06 26.7 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EDP45337.1 - 0.00041 20.0 0.2 0.0028 17.2 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EDP45337.1 - 0.00078 19.4 0.2 0.22 11.4 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EDP45337.1 - 0.0012 18.3 0.1 0.0022 17.4 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EDP45337.1 - 0.0025 18.1 0.0 0.033 14.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EDP45337.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EDP45337.1 - 0.012 16.0 0.1 0.021 15.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EDP45337.1 - 0.016 15.0 0.0 0.055 13.2 0.0 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EDP45337.1 - 0.035 14.6 0.2 0.049 14.1 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 EDP45337.1 - 0.036 14.3 0.1 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EDP45337.1 - 0.045 13.5 0.2 0.11 12.3 0.0 1.7 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EDP45337.1 - 0.068 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EDP45337.1 - 0.087 12.2 0.0 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 EDP45337.1 - 0.099 11.7 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_21 PF13304.6 EDP45337.1 - 0.1 12.4 0.8 0.19 11.5 0.6 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EDP45337.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AEP1 PF17049.5 EDP45337.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 MCM PF00493.23 EDP45338.1 - 2.3e-96 321.2 0.1 4.3e-96 320.4 0.1 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP45338.1 - 7.3e-34 116.3 0.0 1.3e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EDP45338.1 - 2.3e-21 76.0 1.7 6e-21 74.7 1.7 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EDP45338.1 - 3.2e-12 46.9 0.1 1.1e-11 45.2 0.0 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDP45338.1 - 6e-08 32.3 0.1 1.2e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EDP45338.1 - 0.0029 17.5 0.0 0.0063 16.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDP45338.1 - 0.0083 15.8 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 EDP45338.1 - 0.091 12.8 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NOA36 PF06524.12 EDP45338.1 - 1.3 8.2 5.8 2.4 7.4 5.8 1.3 1 0 0 1 1 1 0 NOA36 protein Translin PF01997.16 EDP45341.1 - 9.4e-36 123.7 0.0 1.1e-35 123.5 0.0 1.1 1 0 0 1 1 1 1 Translin family RINT1_TIP1 PF04437.13 EDP45342.1 - 2.8e-70 237.6 0.0 5.9e-70 236.6 0.0 1.5 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Solute_trans_a PF03619.16 EDP45343.1 - 2.4e-86 289.5 20.5 2.9e-86 289.3 20.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha UCR_14kD PF02271.16 EDP45344.1 - 1.7e-40 137.0 0.7 2e-40 136.8 0.7 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Amino_oxidase PF01593.24 EDP45345.1 - 2.9e-12 46.6 0.0 3.7e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FBPase PF00316.20 EDP45346.1 - 2.1e-68 229.5 1.2 2.9e-68 229.1 1.2 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EDP45346.1 - 0.0072 15.9 0.2 0.015 14.8 0.0 1.7 2 0 0 2 2 2 1 Inositol monophosphatase family Perilipin PF03036.16 EDP45347.1 - 0.00094 18.3 4.7 0.0016 17.5 0.0 2.2 1 1 0 2 2 2 1 Perilipin family DUF3972 PF13118.6 EDP45347.1 - 0.016 15.7 0.4 0.036 14.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) DUF2383 PF09537.10 EDP45347.1 - 0.021 15.2 0.7 0.037 14.4 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DUF2937 PF11157.8 EDP45347.1 - 0.044 13.5 1.1 0.15 11.8 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF5532 PF17673.1 EDP45347.1 - 0.063 13.3 0.2 1.3 9.1 0.0 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5532) Apolipoprotein PF01442.18 EDP45347.1 - 0.064 13.1 2.9 0.24 11.3 2.9 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EDP45347.1 - 0.12 13.0 0.9 12 6.5 0.2 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 EDP45347.1 - 0.46 9.8 2.6 0.64 9.3 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cyclin_N PF00134.23 EDP45348.1 - 3.6e-15 55.8 0.2 7.4e-15 54.8 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EDP45348.1 - 1e-07 32.4 0.0 1e-07 32.4 0.0 2.0 2 1 0 2 2 2 1 Cyclin Sec7 PF01369.20 EDP45349.1 - 9.4e-21 74.3 0.0 1.5e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain WD40 PF00400.32 EDP45350.1 - 1.1e-34 117.8 17.0 2.7e-07 31.2 0.0 12.0 13 0 0 13 13 13 6 WD domain, G-beta repeat Utp12 PF04003.12 EDP45350.1 - 3.9e-20 72.2 0.2 6.8e-20 71.4 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EDP45350.1 - 1.3e-14 54.2 0.0 0.22 11.8 0.0 8.7 3 2 6 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EDP45350.1 - 1.7e-05 24.0 0.3 4.2 6.2 0.1 5.2 4 2 2 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 EDP45350.1 - 0.024 13.7 0.2 0.54 9.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 EDP45350.1 - 0.11 10.9 0.0 12 4.2 0.0 3.3 4 0 0 4 4 4 0 Cytochrome D1 heme domain WD40_like PF17005.5 EDP45350.1 - 0.13 11.5 0.0 4.1 6.6 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain DEAD PF00270.29 EDP45351.1 - 1.3e-46 158.5 0.3 2e-46 157.9 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EDP45351.1 - 3.1e-25 88.7 0.0 4.8e-24 84.8 0.0 2.7 2 1 2 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EDP45351.1 - 1.2e-18 67.0 0.5 2.9e-18 65.9 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EDP45351.1 - 0.00011 22.3 0.0 0.00019 21.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Utp21 PF04192.12 EDP45352.1 - 6.6e-46 156.7 0.1 1e-45 156.1 0.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EDP45352.1 - 1.5e-11 44.4 0.0 0.033 14.5 0.0 6.5 4 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDP45352.1 - 4.6e-11 43.1 8.7 0.04 14.8 0.1 8.5 8 0 0 8 8 8 3 WD domain, G-beta repeat ELYS-bb PF16687.5 EDP45352.1 - 0.0032 16.1 0.1 1 7.9 0.0 3.1 2 1 1 3 3 3 1 beta-propeller of ELYS nucleoporin WD40_like PF17005.5 EDP45352.1 - 0.0062 15.9 0.0 6.2 6.1 0.0 3.3 3 1 0 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EDP45352.1 - 0.011 14.7 3.9 1.1 8.1 0.1 4.1 4 2 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 EDP45352.1 - 0.21 11.1 0.4 12 5.3 0.0 2.8 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 AAA_5 PF07728.14 EDP45353.1 - 7.8e-113 372.5 0.0 8.8e-21 74.4 0.0 10.1 8 1 1 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EDP45353.1 - 8.9e-46 154.5 0.4 9.3e-16 58.0 0.0 4.9 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_3 PF07726.11 EDP45353.1 - 1.2e-25 89.8 0.1 5.5e-08 32.7 0.0 7.6 7 1 1 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EDP45353.1 - 2.9e-25 88.4 0.0 1.3e-24 86.3 0.0 2.3 2 0 0 2 2 1 1 Midasin AAA lid domain AAA_7 PF12775.7 EDP45353.1 - 1.1e-23 83.7 0.7 0.00025 20.6 0.1 6.8 6 1 0 6 6 6 5 P-loop containing dynein motor region AAA PF00004.29 EDP45353.1 - 2.3e-22 79.8 0.1 0.001 19.5 0.0 7.2 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 EDP45353.1 - 7.3e-21 74.5 0.0 0.00073 19.6 0.0 7.0 6 0 0 6 6 6 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 EDP45353.1 - 8.6e-19 68.2 0.1 0.054 13.8 0.0 7.3 6 0 0 6 6 6 4 AAA domain AAA_6 PF12774.7 EDP45353.1 - 2.9e-18 65.9 0.5 0.0042 16.1 0.0 8.8 10 0 0 10 10 10 3 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EDP45353.1 - 2.1e-16 60.1 2.1 0.15 12.0 0.1 6.7 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EDP45353.1 - 2.6e-16 59.9 3.7 0.023 14.4 0.1 7.0 6 1 0 6 6 6 5 AAA domain AAA_16 PF13191.6 EDP45353.1 - 1.9e-15 57.6 53.4 0.00055 20.4 1.8 11.8 11 2 0 12 12 9 5 AAA ATPase domain Sigma54_activat PF00158.26 EDP45353.1 - 3.4e-15 56.1 0.1 0.055 13.2 0.0 6.8 6 0 0 6 6 6 4 Sigma-54 interaction domain ABC_tran PF00005.27 EDP45353.1 - 5.2e-14 52.9 0.0 0.4 11.2 0.0 7.0 6 0 0 6 6 6 3 ABC transporter AAA_18 PF13238.6 EDP45353.1 - 1.3e-12 48.4 0.0 0.45 11.1 0.0 7.2 6 0 0 6 6 6 1 AAA domain T2SSE PF00437.20 EDP45353.1 - 1e-11 44.5 4.1 0.086 11.9 0.0 6.6 7 0 0 7 7 6 3 Type II/IV secretion system protein AAA_33 PF13671.6 EDP45353.1 - 8.9e-11 42.1 7.0 0.13 12.5 0.1 7.7 7 0 0 7 7 6 2 AAA domain AAA_29 PF13555.6 EDP45353.1 - 1.3e-10 40.9 0.9 1.8 8.4 0.0 5.9 6 0 0 6 6 5 3 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EDP45353.1 - 1.8e-10 40.5 3.7 1.2 8.5 0.1 7.9 8 0 0 8 8 8 2 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 EDP45353.1 - 7.9e-10 38.9 0.1 0.15 12.0 0.0 5.5 5 0 0 5 5 5 2 RsgA GTPase AAA_14 PF13173.6 EDP45353.1 - 2.1e-09 37.5 0.0 0.022 14.8 0.0 6.8 8 0 0 8 8 6 1 AAA domain RNA_helicase PF00910.22 EDP45353.1 - 3.3e-09 37.1 0.2 3.4 8.1 0.0 6.6 6 0 0 6 6 6 0 RNA helicase Zeta_toxin PF06414.12 EDP45353.1 - 9e-09 34.9 2.1 0.15 11.3 0.0 6.6 7 0 0 7 7 6 1 Zeta toxin AAA_28 PF13521.6 EDP45353.1 - 2.5e-08 34.3 2.9 2.5 8.3 0.0 7.7 7 0 0 7 7 7 1 AAA domain Sigma54_activ_2 PF14532.6 EDP45353.1 - 3.1e-07 30.6 0.5 0.038 14.1 0.0 5.0 4 0 0 4 4 4 1 Sigma-54 interaction domain NACHT PF05729.12 EDP45353.1 - 4.8e-07 29.8 3.7 0.69 9.8 0.1 6.1 6 0 0 6 6 5 1 NACHT domain RuvB_N PF05496.12 EDP45353.1 - 2.1e-06 27.6 5.8 2.8 7.7 0.0 6.5 6 1 0 6 6 6 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EDP45353.1 - 1.3e-05 24.5 0.9 2.2 7.4 0.0 4.7 5 0 0 5 5 5 2 Protein of unknown function (DUF815) AAA_25 PF13481.6 EDP45353.1 - 2e-05 24.3 11.9 2.1 7.9 0.1 7.4 8 0 0 8 8 7 1 AAA domain AAA_19 PF13245.6 EDP45353.1 - 0.00024 21.4 5.9 4 7.8 0.0 5.8 7 0 0 7 7 4 0 AAA domain TIP49 PF06068.13 EDP45353.1 - 0.00062 19.1 1.6 0.016 14.4 0.1 3.1 3 0 0 3 3 3 1 TIP49 P-loop domain Rad17 PF03215.15 EDP45353.1 - 0.00098 19.1 3.0 21 4.9 0.0 5.5 6 0 0 6 6 5 0 Rad17 P-loop domain AAA_24 PF13479.6 EDP45353.1 - 0.0021 17.8 0.1 12 5.6 0.0 5.1 7 0 0 7 7 4 0 AAA domain PduV-EutP PF10662.9 EDP45353.1 - 0.0025 17.6 0.7 7.7 6.3 0.1 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation AAA_8 PF12780.7 EDP45353.1 - 0.0027 17.1 1.1 2.6 7.3 0.0 3.7 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 SRP54 PF00448.22 EDP45353.1 - 0.0028 17.3 3.2 4.1 7.0 0.2 4.6 5 0 0 5 5 4 0 SRP54-type protein, GTPase domain ResIII PF04851.15 EDP45353.1 - 0.0043 17.1 0.6 5.2 7.0 0.1 3.7 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit cobW PF02492.19 EDP45353.1 - 0.0079 15.8 6.1 5.1 6.6 0.1 5.2 6 0 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain vWA-TerF-like PF10138.9 EDP45353.1 - 0.0086 16.2 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus UTP15_C PF09384.10 EDP45353.1 - 0.012 15.3 0.0 7.1 6.3 0.0 3.2 3 0 0 3 3 2 0 UTP15 C terminal Viral_helicase1 PF01443.18 EDP45353.1 - 0.012 15.3 0.0 4 7.1 0.0 4.2 5 0 0 5 5 4 0 Viral (Superfamily 1) RNA helicase IPT PF01745.16 EDP45353.1 - 0.012 15.0 0.2 13 5.0 0.1 3.4 3 0 0 3 3 3 0 Isopentenyl transferase SRPRB PF09439.10 EDP45353.1 - 0.094 12.1 0.3 28 4.1 0.0 4.3 5 0 0 5 5 5 0 Signal recognition particle receptor beta subunit dNK PF01712.19 EDP45353.1 - 0.12 12.2 4.3 50 3.7 0.0 5.8 7 0 0 7 7 7 0 Deoxynucleoside kinase Bac_DnaA PF00308.18 EDP45353.1 - 0.13 12.1 0.0 72 3.1 0.0 4.0 4 0 0 4 4 4 0 Bacterial dnaA protein ATPase_2 PF01637.18 EDP45353.1 - 0.19 11.6 0.0 15 5.4 0.0 3.3 4 0 0 4 4 2 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EDP45353.1 - 0.41 9.9 4.8 8.8 5.6 0.0 4.0 4 0 0 4 4 3 0 KaiC AAA_23 PF13476.6 EDP45353.1 - 0.42 11.1 27.8 2 8.9 0.0 6.6 6 1 0 6 6 5 0 AAA domain Roc PF08477.13 EDP45353.1 - 0.7 10.1 7.8 29 4.9 0.1 5.1 7 0 0 7 7 3 0 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 EDP45353.1 - 0.73 9.3 4.4 50 3.3 0.0 4.4 5 0 0 5 5 5 0 PhoH-like protein ATP_bind_1 PF03029.17 EDP45353.1 - 2 8.1 5.6 3 7.5 0.1 3.7 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 EDP45353.1 - 2.9 7.8 6.5 46 3.9 0.2 4.2 5 0 0 5 5 3 0 NTPase FtsK_SpoIIIE PF01580.18 EDP45353.1 - 4.1 6.7 7.3 4.4 6.6 0.1 3.9 5 0 0 5 5 4 0 FtsK/SpoIIIE family Foie-gras_1 PF11817.8 EDP45354.1 - 1e-16 61.3 13.3 4.7e-11 42.8 2.3 2.7 3 0 0 3 3 3 2 Foie gras liver health family 1 TRAPPC10 PF12584.8 EDP45354.1 - 0.0011 18.6 0.0 0.0034 17.1 0.0 1.7 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 TPR_12 PF13424.6 EDP45354.1 - 0.12 12.7 3.8 1.8 8.9 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HA2 PF04408.23 EDP45355.1 - 1.4e-14 54.3 1.9 2.3e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EDP45355.1 - 7.7e-14 52.0 0.0 1.7e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EDP45355.1 - 2.7e-11 43.7 0.0 6.7e-11 42.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EDP45355.1 - 8.4e-11 42.0 0.1 1.7e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ATPase PF06745.13 EDP45355.1 - 0.00056 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 EDP45355.1 - 0.0015 18.8 0.1 0.0059 16.9 0.1 2.0 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EDP45355.1 - 0.0094 16.0 0.0 0.077 13.0 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EDP45355.1 - 0.012 14.7 0.2 0.064 12.3 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 EDP45355.1 - 0.054 13.9 2.0 0.096 13.1 0.2 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 EDP45355.1 - 0.064 13.6 0.0 0.22 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EDP45355.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Rad17 PF03215.15 EDP45355.1 - 0.19 11.6 0.0 0.45 10.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_7 PF12775.7 EDP45355.1 - 0.2 11.2 0.0 0.37 10.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EDP45355.1 - 0.21 11.5 0.9 0.62 10.0 0.2 2.3 2 1 0 2 2 2 0 NACHT domain Sec2p PF06428.11 EDP45356.1 - 1.5e-20 72.9 5.1 1.5e-20 72.9 5.1 2.6 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p RPAP1_N PF08621.10 EDP45356.1 - 0.057 13.2 0.2 0.057 13.2 0.2 2.3 2 0 0 2 2 2 0 RPAP1-like, N-terminal GCN5L1 PF06320.13 EDP45356.1 - 3.7 7.7 8.1 1.3 9.2 3.3 2.4 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DEAD_2 PF06733.15 EDP45357.1 - 7.3e-54 182.0 0.1 9.6e-53 178.4 0.0 2.6 2 1 0 2 2 2 1 DEAD_2 HBB PF06777.11 EDP45357.1 - 5.7e-46 156.6 2.4 6.4e-43 146.6 0.6 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EDP45357.1 - 5.3e-44 150.4 0.0 1.1e-43 149.3 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 EDP45357.1 - 0.00011 22.3 0.0 0.0074 16.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EDP45357.1 - 0.16 12.3 0.3 21 5.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EDP45358.1 - 4.4e-43 147.1 0.0 1.8e-21 77.1 0.0 4.6 3 2 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EDP45358.1 - 1.6e-16 61.0 0.1 0.00045 20.1 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EDP45358.1 - 2e-13 50.3 2.0 0.0041 16.6 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EDP45358.1 - 9.6e-09 34.9 0.2 0.0053 16.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Cnd1 PF12717.7 EDP45358.1 - 2.6e-06 27.6 0.1 0.016 15.3 0.1 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EDP45358.1 - 5e-06 26.2 0.0 0.065 12.8 0.0 2.7 1 1 1 2 2 2 2 CLASP N terminal AAA_22 PF13401.6 EDP45358.1 - 6.1e-06 26.6 0.0 0.37 11.1 0.0 4.7 6 0 0 6 6 4 2 AAA domain AAA_23 PF13476.6 EDP45358.1 - 5.2e-05 23.8 7.9 0.012 16.1 0.0 3.6 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EDP45358.1 - 0.00031 21.2 0.1 0.38 11.1 0.0 3.3 3 1 0 3 3 3 1 AAA ATPase domain MMR_HSR1 PF01926.23 EDP45358.1 - 0.00045 20.3 0.0 0.98 9.5 0.0 3.2 3 0 0 3 3 2 1 50S ribosome-binding GTPase NACHT PF05729.12 EDP45358.1 - 0.00051 20.0 0.0 1.3 8.9 0.0 3.0 3 0 0 3 3 2 2 NACHT domain RsgA_GTPase PF03193.16 EDP45358.1 - 0.0006 19.8 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EDP45358.1 - 0.00064 20.0 0.0 0.7 10.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDP45358.1 - 0.00095 19.7 0.0 1.4 9.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EDP45358.1 - 0.00096 18.4 0.0 0.18 10.9 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit AAA_15 PF13175.6 EDP45358.1 - 0.0013 18.5 2.3 0.18 11.5 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 EDP45358.1 - 0.0018 18.4 0.0 1.9 8.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain HEAT_2 PF13646.6 EDP45358.1 - 0.0019 18.5 0.7 0.24 11.8 0.1 3.4 2 1 1 3 3 3 1 HEAT repeats NB-ARC PF00931.22 EDP45358.1 - 0.0026 17.0 0.2 2 7.5 0.0 2.8 3 0 0 3 3 2 1 NB-ARC domain AAA PF00004.29 EDP45358.1 - 0.0027 18.1 0.0 2.9 8.3 0.0 4.4 6 0 0 6 6 3 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EDP45358.1 - 0.004 17.3 5.8 0.24 11.4 0.1 4.2 4 0 0 4 4 4 1 Helicase HerA, central domain EF-hand_7 PF13499.6 EDP45358.1 - 0.0052 17.2 0.3 0.75 10.3 0.0 3.3 3 0 0 3 3 2 1 EF-hand domain pair RNA_helicase PF00910.22 EDP45358.1 - 0.0059 17.0 0.0 8.1 6.9 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Chromo PF00385.24 EDP45358.1 - 0.0061 16.5 0.0 0.019 14.9 0.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MeaB PF03308.16 EDP45358.1 - 0.007 15.4 0.2 0.4 9.6 0.0 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EDP45358.1 - 0.0071 15.7 0.3 20 4.4 0.0 3.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_30 PF13604.6 EDP45358.1 - 0.0095 15.7 0.4 9.5 5.9 0.0 3.5 4 0 0 4 4 3 0 AAA domain AAA_24 PF13479.6 EDP45358.1 - 0.033 13.9 0.0 3.7 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EDP45358.1 - 0.047 13.9 1.3 2.1 8.6 0.1 3.7 3 2 0 3 3 3 0 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EDP45358.1 - 0.059 13.6 0.0 14 6.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase HEAT_EZ PF13513.6 EDP45358.1 - 0.061 13.8 0.8 20 5.8 0.0 5.0 5 1 2 7 7 6 0 HEAT-like repeat NTPase_1 PF03266.15 EDP45358.1 - 0.064 13.2 0.0 7.5 6.4 0.0 2.6 2 0 0 2 2 2 0 NTPase ATP_bind_1 PF03029.17 EDP45358.1 - 0.064 13.0 1.0 4.9 6.8 0.0 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EDP45358.1 - 0.074 12.6 0.0 9 5.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EDP45358.1 - 0.086 12.4 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region 4HB PF17947.1 EDP45358.1 - 0.1 12.7 0.0 0.46 10.6 0.0 2.2 1 0 0 1 1 1 0 Four helical bundle domain AAA_13 PF13166.6 EDP45358.1 - 0.13 10.9 3.3 1.2 7.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EDP45358.1 - 0.15 11.7 0.3 27 4.3 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EDP45358.1 - 0.16 11.9 6.5 12 5.7 0.0 4.2 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EDP45358.1 - 0.19 11.7 4.8 32 4.5 0.0 4.7 5 0 0 5 5 4 0 AAA domain (dynein-related subfamily) DUF3584 PF12128.8 EDP45358.1 - 1 6.8 8.3 0.99 6.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) She9_MDM33 PF05546.11 EDP45359.1 - 1.3e-57 194.8 6.8 1.8e-57 194.3 6.8 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family DUF2207 PF09972.9 EDP45359.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ZapB PF06005.12 EDP45359.1 - 0.88 10.1 5.5 0.69 10.4 2.0 2.2 2 0 0 2 2 2 0 Cell division protein ZapB AMP-binding PF00501.28 EDP45360.1 - 1.7e-88 297.1 0.0 2e-88 296.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EDP45360.1 - 5.4e-24 85.0 0.2 1.5e-23 83.5 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EDP45360.1 - 2.5e-14 52.9 0.8 5.5e-14 51.8 0.8 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ATP-synt_E PF05680.12 EDP45361.1 - 5.1e-20 71.6 0.1 5.4e-20 71.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain G2BR PF18442.1 EDP45361.1 - 0.024 14.3 0.3 0.038 13.6 0.3 1.3 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) NAC PF01849.18 EDP45362.1 - 8e-22 77.0 0.1 1.4e-21 76.2 0.1 1.5 1 0 0 1 1 1 1 NAC domain DUF3602 PF12223.8 EDP45363.1 - 0.4 11.3 10.2 1.1 9.9 10.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3602) Rpp20 PF12328.8 EDP45363.1 - 0.7 9.9 5.0 1 9.4 5.0 1.2 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P D123 PF07065.14 EDP45364.1 - 3.8e-89 298.9 0.0 4.4e-89 298.7 0.0 1.0 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 EDP45364.1 - 0.0018 18.3 0.1 0.0051 16.9 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EDP45364.1 - 0.027 14.3 0.1 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain, R2K clade family 2 tRNA-synt_2 PF00152.20 EDP45365.1 - 3.1e-67 226.9 0.0 3.8e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EDP45365.1 - 5.5e-07 29.5 0.1 9.1e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain ECH_2 PF16113.5 EDP45366.1 - 1.9e-86 290.6 0.0 6.5e-86 288.9 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EDP45366.1 - 1.6e-15 57.1 0.3 1.3e-12 47.6 0.1 3.1 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase AHH PF14412.6 EDP45366.1 - 0.028 14.5 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DMRL_synthase PF00885.19 EDP45367.1 - 8.5e-56 187.7 0.1 9.6e-56 187.5 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Mit_ribos_Mrp51 PF11709.8 EDP45368.1 - 1.7e-16 60.8 0.1 1.7e-16 60.8 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit DUF4805 PF16063.5 EDP45368.1 - 0.0099 15.2 0.4 0.0099 15.2 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4805) Coatomer_WDAD PF04053.14 EDP45369.1 - 1.8e-124 416.2 0.0 2.9e-124 415.5 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EDP45369.1 - 2.3e-80 270.3 0.0 3.3e-80 269.8 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EDP45369.1 - 1.8e-43 145.7 13.2 2.8e-08 34.3 0.1 8.4 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45369.1 - 6.8e-14 51.9 1.0 0.0018 18.6 0.1 6.9 5 2 3 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP45369.1 - 0.00047 18.9 8.0 0.04 12.6 0.2 4.2 2 1 3 5 5 5 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EDP45369.1 - 0.13 11.1 0.1 3.7 6.4 0.0 3.1 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EDP45369.1 - 0.21 10.3 0.8 21 3.7 0.0 3.4 3 1 1 4 4 4 0 Nup133 N terminal like Rot1 PF10681.9 EDP45370.1 - 2.6e-45 154.5 4.6 3.2e-45 154.2 4.6 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Gpi16 PF04113.14 EDP45371.1 - 1.4e-82 277.9 0.0 3e-48 164.6 0.0 2.2 1 1 1 2 2 2 2 Gpi16 subunit, GPI transamidase component NAD_binding_6 PF08030.12 EDP45372.1 - 1.5e-13 51.1 0.0 7.8e-13 48.8 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EDP45372.1 - 1.7e-13 50.6 0.0 4.7e-12 46.0 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain NUC173 PF08161.12 EDP45373.1 - 9e-56 188.8 0.0 3.3e-55 186.9 0.0 2.1 2 0 0 2 2 2 1 NUC173 domain DUF3384 PF11864.8 EDP45374.1 - 0.078 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) MMS19_C PF12460.8 EDP45374.1 - 0.39 9.8 1.4 0.55 9.3 1.4 1.2 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal LETM1 PF07766.13 EDP45375.1 - 5.6e-93 311.2 1.2 5.6e-93 311.2 1.2 2.2 2 0 0 2 2 2 1 LETM1-like protein EF-hand_7 PF13499.6 EDP45375.1 - 6.8e-05 23.2 2.0 0.0022 18.4 0.1 3.7 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_8 PF13833.6 EDP45375.1 - 0.00015 21.5 0.7 0.0013 18.5 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EDP45375.1 - 0.0064 16.3 0.2 11 6.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain DUF5063 PF16702.5 EDP45375.1 - 0.04 14.3 0.3 0.089 13.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) Syntaxin-6_N PF09177.11 EDP45375.1 - 0.19 12.3 0.1 0.19 12.3 0.1 3.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal WD40 PF00400.32 EDP45376.1 - 6.6e-17 61.6 16.7 0.002 18.9 0.0 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 EDP45376.1 - 1.2e-16 60.9 0.0 2.1e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EDP45376.1 - 0.00018 21.8 0.0 0.069 13.5 0.0 3.6 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M13_N PF05649.13 EDP45377.1 - 7.5e-75 253.0 0.0 9.8e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EDP45377.1 - 1.5e-52 178.2 0.0 2e-52 177.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 EDP45378.1 - 2.9e-55 188.5 0.0 6.1e-55 187.5 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.21 EDP45378.1 - 1.9e-32 112.6 0.3 7.5e-19 68.2 0.0 2.4 1 1 1 2 2 2 2 Peptidase family M13 Peptidase_S49_N PF08496.10 EDP45378.1 - 0.28 11.3 3.8 0.5 10.4 3.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Rrn6 PF10214.9 EDP45378.1 - 0.73 8.2 7.7 1.1 7.6 7.7 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF155 PF02582.14 EDP45379.1 - 1.1e-46 159.2 0.0 1.8e-46 158.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF2040 PF09745.9 EDP45380.1 - 9.4e-37 125.8 21.9 9.4e-37 125.8 21.9 1.9 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) Acetate_kinase PF00871.17 EDP45380.1 - 0.13 10.9 0.0 0.92 8.1 0.2 1.9 2 0 0 2 2 2 0 Acetokinase family ACPS PF01648.20 EDP45381.1 - 1.6e-13 50.8 0.0 1.2e-12 47.9 0.0 2.1 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Vps55 PF04133.14 EDP45382.1 - 1.2e-17 63.9 3.1 1.3e-17 63.8 3.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 RRM_1 PF00076.22 EDP45383.1 - 0.0017 18.2 0.0 0.0052 16.6 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAPPC9-Trs120 PF08626.11 EDP45384.1 - 2e-140 469.4 0.0 2.6e-140 469.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit AChE_tetra PF08674.10 EDP45384.1 - 0.22 11.2 0.4 0.47 10.2 0.4 1.5 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain PALP PF00291.25 EDP45385.1 - 3e-49 168.0 0.1 4.2e-49 167.6 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HLH PF00010.26 EDP45386.1 - 4.4e-05 23.4 0.1 0.00012 21.9 0.1 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SKN1 PF03935.15 EDP45387.1 - 1.6e-179 597.5 4.9 2e-179 597.2 4.9 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) RNaseH_pPIWI_RE PF13032.6 EDP45387.1 - 0.13 12.2 0.3 0.85 9.5 0.2 2.0 2 0 0 2 2 2 0 RNaseH domain of pPIWI_RE Adaptin_N PF01602.20 EDP45388.1 - 1e-94 318.0 7.2 1.2e-94 317.8 7.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EDP45388.1 - 7.9e-47 159.3 4.2 1.7e-44 151.7 0.7 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EDP45388.1 - 2e-06 28.1 3.0 0.005 17.2 0.2 3.2 4 0 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 EDP45388.1 - 0.00025 21.5 1.7 0.94 10.1 0.3 3.7 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 EDP45388.1 - 0.00034 20.6 2.1 0.097 13.0 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat UTP15_C PF09384.10 EDP45389.1 - 2.8e-45 153.6 0.0 4.1e-45 153.1 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EDP45389.1 - 4.2e-22 78.0 4.2 2.7e-05 24.8 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45389.1 - 8.4e-06 26.0 0.0 0.054 13.8 0.0 3.9 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EDP45389.1 - 0.0016 17.1 0.2 0.0053 15.3 0.0 1.8 1 1 1 2 2 2 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EDP45389.1 - 0.0059 15.6 0.0 1.2 8.0 0.0 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EDP45389.1 - 0.17 10.2 0.0 12 4.0 0.0 2.3 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Ribosomal_S21e PF01249.18 EDP45390.1 - 1.6e-35 121.0 0.1 1.8e-35 120.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e PUF PF00806.19 EDP45391.1 - 7.1e-05 22.3 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Pumilio-family RNA binding repeat FXR_C1 PF16096.5 EDP45391.1 - 0.024 14.8 1.7 8.4 6.7 0.2 2.7 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 PUF PF00806.19 EDP45392.1 - 2.1e-43 143.6 1.6 1.7e-06 27.4 0.0 6.3 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat Herpes_glycop_H PF02489.16 EDP45392.1 - 0.039 12.5 0.0 0.068 11.7 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein H main domain TetR_C_24 PF17932.1 EDP45392.1 - 0.28 11.5 1.2 1.7 8.9 0.1 2.6 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RabGAP-TBC PF00566.18 EDP45393.1 - 1.3e-27 96.9 1.6 7.5e-27 94.4 1.6 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain CoA_trans PF01144.23 EDP45394.1 - 9.9e-93 309.5 1.8 7.8e-57 192.2 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EDP45394.1 - 0.01 15.7 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Mal_decarbox_Al PF16957.5 EDP45394.1 - 0.019 13.3 0.0 0.035 12.4 0.0 1.3 1 0 0 1 1 1 0 Malonate decarboxylase, alpha subunit, transporter DUF21 PF01595.20 EDP45395.1 - 3.5e-30 105.0 0.1 5.2e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EDP45395.1 - 0.12 12.9 0.3 5.1 7.6 0.0 2.9 3 0 0 3 3 3 0 CBS domain ATXN-1_C PF12547.8 EDP45395.1 - 2.5 8.5 6.0 2.3 8.6 2.3 2.6 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator DnaJ_C PF01556.18 EDP45396.1 - 2.1e-40 138.2 0.2 2.7e-40 137.8 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EDP45396.1 - 2.2e-17 63.1 20.4 3.6e-17 62.5 20.4 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDP45396.1 - 0.0029 17.5 8.7 0.16 12.0 1.0 2.6 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EDP45396.1 - 0.12 12.4 12.1 1 9.4 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EDP45396.1 - 0.12 12.0 8.4 0.29 10.8 1.8 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Cytochrom_c3_2 PF14537.6 EDP45396.1 - 0.54 10.8 7.7 0.8 10.2 1.7 2.4 2 0 0 2 2 2 0 Cytochrome c3 Cytochrom_CIII PF02085.16 EDP45396.1 - 0.74 10.2 7.5 1.7 9.1 7.4 1.6 1 1 0 1 1 1 0 Class III cytochrome C family Cytochrome_C7 PF14522.6 EDP45396.1 - 0.85 9.7 11.8 20 5.3 9.6 2.4 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c zf-RING_10 PF16685.5 EDP45396.1 - 2.8 8.1 11.1 1.1 9.4 1.4 2.2 1 1 1 2 2 2 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 EDP45396.1 - 7.7 6.6 12.3 62 3.7 12.3 2.1 1 1 0 1 1 1 0 zinc-ribbons His_Phos_1 PF00300.22 EDP45397.1 - 6.4e-18 65.2 0.2 1.2e-17 64.3 0.1 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF641 PF04859.12 EDP45397.1 - 0.0057 17.0 0.4 0.0095 16.3 0.4 1.4 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) VWA_2 PF13519.6 EDP45397.1 - 0.085 13.5 0.1 8.4 7.1 0.1 2.3 1 1 0 2 2 2 0 von Willebrand factor type A domain DUF3450 PF11932.8 EDP45397.1 - 0.27 10.5 3.5 0.46 9.8 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Ribosomal_L14 PF00238.19 EDP45398.1 - 6.5e-42 142.5 1.7 7.2e-42 142.3 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e TRM PF02005.16 EDP45399.1 - 1.6e-90 304.0 0.0 2e-90 303.7 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF1110 PF06533.12 EDP45399.1 - 0.06 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) Rubredoxin_2 PF18073.1 EDP45399.1 - 0.088 12.5 7.4 0.055 13.2 1.5 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain JTB PF05439.12 EDP45399.1 - 1.1 9.3 3.8 20 5.3 1.6 2.3 1 1 1 2 2 2 0 Jumping translocation breakpoint protein (JTB) TRM PF02005.16 EDP45400.1 - 1e-08 34.8 0.0 1.3e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase H2O2_YaaD PF03883.14 EDP45400.1 - 0.081 12.4 0.1 0.09 12.3 0.1 1.1 1 0 0 1 1 1 0 Peroxide stress protein YaaA Ofd1_CTDD PF10637.9 EDP45401.1 - 9.9e-77 257.7 0.0 1.8e-70 237.2 0.0 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EDP45401.1 - 6.6e-31 106.8 0.0 1.3e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EDP45401.1 - 8.6e-15 55.4 0.1 2.2e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNA_pol_3_Rpc31 PF11705.8 EDP45401.1 - 0.0043 17.4 10.2 0.0083 16.4 10.2 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 EDP45401.1 - 0.094 12.4 10.5 0.17 11.6 10.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CSRNP_N PF16019.5 EDP45401.1 - 0.11 12.4 1.1 0.21 11.5 0.4 1.7 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus FYDLN_acid PF09538.10 EDP45401.1 - 0.32 11.7 14.7 0.84 10.3 14.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) BUD22 PF09073.10 EDP45401.1 - 0.34 10.2 7.9 0.49 9.7 7.9 1.3 1 0 0 1 1 1 0 BUD22 RXT2_N PF08595.11 EDP45401.1 - 2 8.4 5.8 4.9 7.2 5.8 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 EDP45401.1 - 3.4 8.1 14.3 9.7 6.7 14.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain AAA PF00004.29 EDP45402.1 - 6e-52 175.6 0.0 3.3e-42 144.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EDP45402.1 - 3.7e-23 81.7 0.5 8e-23 80.7 0.5 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EDP45402.1 - 9.7e-13 47.7 0.7 2.4e-09 36.8 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EDP45402.1 - 1.4e-09 38.6 5.2 0.00072 20.0 0.9 4.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 EDP45402.1 - 2.2e-07 31.2 0.2 0.0092 16.2 0.0 3.4 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EDP45402.1 - 1.1e-06 29.2 0.0 0.028 15.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EDP45402.1 - 3.1e-06 27.5 0.4 0.1 12.9 0.0 3.1 2 2 0 2 2 2 2 AAA domain NACHT PF05729.12 EDP45402.1 - 9.1e-06 25.7 3.9 0.49 10.3 0.1 3.9 4 0 0 4 4 4 2 NACHT domain Viral_helicase1 PF01443.18 EDP45402.1 - 3.3e-05 23.7 0.0 0.064 13.0 0.0 2.6 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 EDP45402.1 - 0.00017 21.6 0.0 0.061 13.2 0.0 3.2 3 0 0 3 3 3 1 Rad17 P-loop domain TsaE PF02367.17 EDP45402.1 - 0.00018 21.5 0.2 0.91 9.5 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EDP45402.1 - 0.00021 21.1 0.0 0.0034 17.2 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EDP45402.1 - 0.00048 20.1 0.0 0.74 9.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EDP45402.1 - 0.00066 20.0 0.0 1.4 9.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EDP45402.1 - 0.00092 19.3 0.0 0.47 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDP45402.1 - 0.0012 18.6 0.8 0.01 15.6 0.1 2.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EDP45402.1 - 0.0014 18.1 0.2 0.88 8.9 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EDP45402.1 - 0.0014 18.9 0.0 2.4 8.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EDP45402.1 - 0.0044 16.3 0.1 2.7 7.1 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain Zeta_toxin PF06414.12 EDP45402.1 - 0.0054 16.0 0.2 3.7 6.8 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 EDP45402.1 - 0.0055 16.4 0.0 0.44 10.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EDP45402.1 - 0.0064 15.7 0.1 0.14 11.3 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_17 PF13207.6 EDP45402.1 - 0.0074 16.7 1.2 0.41 11.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_2 PF07724.14 EDP45402.1 - 0.01 16.0 0.0 0.032 14.4 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EDP45402.1 - 0.022 15.3 0.0 2.7 8.5 0.0 2.7 2 0 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EDP45402.1 - 0.023 13.8 0.0 0.62 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EDP45402.1 - 0.026 14.2 0.1 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein SKI PF01202.22 EDP45402.1 - 0.046 13.8 0.0 2.1 8.5 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase AAA_30 PF13604.6 EDP45402.1 - 0.065 12.9 2.8 0.19 11.4 0.2 2.8 3 0 0 3 3 3 0 AAA domain Bac_DnaA PF00308.18 EDP45402.1 - 0.099 12.5 0.0 19 5.0 0.0 3.0 3 1 0 3 3 2 0 Bacterial dnaA protein ATP_bind_1 PF03029.17 EDP45402.1 - 0.12 12.2 0.3 0.29 10.9 0.0 1.8 2 0 0 2 2 1 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EDP45402.1 - 0.12 11.9 0.0 18 4.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 EDP45402.1 - 0.14 11.4 0.0 4.7 6.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) APS_kinase PF01583.20 EDP45402.1 - 0.2 11.6 0.9 8.3 6.3 0.0 3.5 3 1 1 4 4 4 0 Adenylylsulphate kinase AAA_25 PF13481.6 EDP45402.1 - 0.2 11.2 6.2 9.3 5.8 0.2 3.8 2 2 1 4 4 4 0 AAA domain NTPase_1 PF03266.15 EDP45402.1 - 0.25 11.2 0.9 5.6 6.8 0.0 2.7 3 0 0 3 3 2 0 NTPase Macoilin PF09726.9 EDP45402.1 - 0.58 8.7 7.1 0.85 8.1 7.1 1.1 1 0 0 1 1 1 0 Macoilin family Gly_transf_sug PF04488.15 EDP45403.1 - 2.5e-20 72.9 0.0 5.1e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ABC_membrane PF00664.23 EDP45404.1 - 2.9e-70 237.0 26.0 2.3e-36 125.9 5.2 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EDP45404.1 - 9.4e-47 159.0 0.0 5.2e-29 101.5 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EDP45404.1 - 1.1e-05 25.0 0.1 0.069 12.6 0.1 3.7 2 2 1 4 4 4 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EDP45404.1 - 4.9e-05 23.4 0.6 0.13 12.4 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EDP45404.1 - 0.00019 21.8 1.9 0.11 12.9 0.2 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EDP45404.1 - 0.0012 18.6 1.2 0.59 9.9 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EDP45404.1 - 0.0039 17.3 5.0 0.085 12.9 0.2 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 EDP45404.1 - 0.0057 16.6 0.4 1.2 9.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EDP45404.1 - 0.0072 16.4 1.3 0.25 11.4 0.2 2.4 2 0 0 2 2 2 1 Dynamin family MeaB PF03308.16 EDP45404.1 - 0.0088 15.1 1.1 0.023 13.7 0.2 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 EDP45404.1 - 0.069 12.9 0.1 1.6 8.4 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein NB-ARC PF00931.22 EDP45404.1 - 0.15 11.3 2.1 5.9 6.0 0.3 2.9 2 1 0 2 2 2 0 NB-ARC domain AAA_21 PF13304.6 EDP45404.1 - 0.41 10.4 1.1 21 4.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Aconitase PF00330.20 EDP45405.1 - 2.5e-43 148.8 0.0 2.9e-43 148.5 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase PF00330.20 EDP45406.1 - 7.4e-67 226.3 0.1 1e-66 225.8 0.1 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EDP45406.1 - 7e-31 107.3 0.0 1.4e-30 106.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain MRP-L28 PF09812.9 EDP45406.1 - 0.0023 18.1 1.1 0.099 12.8 0.1 2.3 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L28 DUF521 PF04412.13 EDP45406.1 - 0.017 13.9 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) SGS PF05002.15 EDP45407.1 - 5.1e-31 106.6 0.1 9.4e-31 105.8 0.1 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.16 EDP45407.1 - 8.2e-10 39.6 0.0 1.3e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 CS domain DUF2057 PF09829.9 EDP45407.1 - 0.04 14.1 0.4 0.071 13.3 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Alg6_Alg8 PF03155.15 EDP45408.1 - 8.1e-152 506.6 38.1 9.3e-152 506.4 38.1 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family OMPdecase PF00215.24 EDP45410.1 - 2.9e-69 233.1 0.0 5.9e-69 232.1 0.0 1.5 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family HhH-GPD PF00730.25 EDP45410.1 - 3.1e-18 66.2 0.0 1.1e-17 64.5 0.0 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EDP45410.1 - 2e-07 30.5 0.0 8.4e-07 28.6 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif Kinesin PF00225.23 EDP45411.1 - 3.2e-23 82.2 0.1 3.7e-23 82.0 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EDP45411.1 - 2.3e-18 66.5 0.0 2.6e-18 66.4 0.0 1.0 1 0 0 1 1 1 1 Microtubule binding PhoH PF02562.16 EDP45411.1 - 0.026 14.0 0.1 0.031 13.7 0.1 1.2 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 EDP45411.1 - 0.073 12.1 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein PIF1 PF05970.14 EDP45411.1 - 0.094 11.9 0.2 0.12 11.5 0.2 1.1 1 0 0 1 1 1 0 PIF1-like helicase Thioredoxin_12 PF18400.1 EDP45411.1 - 0.2 11.5 0.1 0.28 11.0 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Kinesin PF00225.23 EDP45412.1 - 2.5e-40 138.4 1.2 4e-40 137.7 0.1 2.0 2 0 0 2 2 2 1 Kinesin motor domain GIT_CC PF16559.5 EDP45412.1 - 0.0065 16.3 3.3 0.0065 16.3 3.3 5.1 5 0 0 5 5 5 1 GIT coiled-coil Rho guanine nucleotide exchange factor Cyclase_polyket PF04673.12 EDP45412.1 - 0.054 13.7 0.2 0.14 12.4 0.2 1.7 1 0 0 1 1 1 0 Polyketide synthesis cyclase zf-RING_2 PF13639.6 EDP45414.1 - 1.7e-08 34.7 7.8 3.4e-08 33.7 7.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EDP45414.1 - 6.8e-06 26.3 6.7 1.7e-05 25.0 6.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EDP45414.1 - 9.5e-05 22.2 8.4 0.00019 21.3 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EDP45414.1 - 0.00018 21.5 2.4 0.00041 20.4 2.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EDP45414.1 - 0.00097 18.9 7.9 0.0029 17.4 7.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EDP45414.1 - 0.0017 18.5 3.9 0.0041 17.3 3.9 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EDP45414.1 - 0.027 14.6 6.1 0.063 13.4 6.1 1.7 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 EDP45414.1 - 0.055 13.1 4.6 0.12 12.0 4.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EDP45414.1 - 0.067 13.1 1.2 0.15 12.0 1.2 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.6 EDP45414.1 - 0.069 13.0 5.1 0.13 12.1 5.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EDP45414.1 - 0.15 11.9 7.2 0.074 12.8 4.1 2.2 2 0 0 2 2 2 0 RING-like zinc finger Zf_RING PF16744.5 EDP45414.1 - 0.35 11.0 2.4 0.81 9.8 2.4 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING-like PF08746.11 EDP45414.1 - 2.6 8.4 6.7 5.2 7.5 6.7 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_5 PF14634.6 EDP45414.1 - 2.7 8.0 7.1 5.6 7.0 7.1 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EDP45414.1 - 3.4 7.6 4.8 6.7 6.7 4.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_9 PF13901.6 EDP45414.1 - 3.6 7.5 5.7 2.4 8.1 3.4 1.9 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 EDP45414.1 - 4.5 7.3 6.0 8.6 6.3 6.0 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EDP45414.1 - 6.3 6.7 6.5 34 4.4 7.2 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Exo_endo_phos PF03372.23 EDP45415.1 - 0.041 13.4 0.0 0.2 11.1 0.0 1.9 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family LEA_2 PF03168.13 EDP45416.1 - 0.06 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Late embryogenesis abundant protein CN_hydrolase PF00795.22 EDP45418.1 - 1.5e-20 73.6 0.0 3.7e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase TPP_enzyme_N PF02776.18 EDP45419.1 - 1.2e-37 129.2 0.0 2.5e-37 128.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EDP45419.1 - 2e-18 66.5 0.0 4.5e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EDP45419.1 - 3.9e-15 55.9 0.1 1.2e-14 54.4 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CENP-Q PF13094.6 EDP45420.1 - 0.041 14.1 0.5 0.23 11.6 0.0 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CpXC PF14353.6 EDP45420.1 - 0.11 12.6 1.5 5.1 7.2 0.1 2.4 2 0 0 2 2 2 0 CpXC protein zf-CCHC_4 PF14392.6 EDP45420.1 - 0.43 10.3 15.3 0.29 10.9 0.2 3.3 3 0 0 3 3 3 0 Zinc knuckle Rad50_zn_hook PF04423.14 EDP45420.1 - 1.1 9.2 3.8 0.59 10.0 0.2 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-CCHC PF00098.23 EDP45420.1 - 4.8 7.4 23.4 0.73 10.0 3.9 4.2 4 1 0 4 4 4 0 Zinc knuckle AAA_16 PF13191.6 EDP45421.1 - 2.5e-08 34.5 9.2 1.5e-07 31.9 0.0 3.7 4 1 1 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 EDP45421.1 - 2.8e-06 27.6 0.1 2.1e-05 24.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EDP45421.1 - 4.2e-06 27.2 0.0 9.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EDP45421.1 - 0.00011 22.3 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 EDP45421.1 - 0.00033 21.0 0.0 0.00096 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EDP45421.1 - 0.00043 20.1 0.1 0.0014 18.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EDP45421.1 - 0.015 15.1 0.0 0.1 12.3 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA12 PF10443.9 EDP45421.1 - 0.02 13.6 0.0 0.041 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA12 protein AAA_14 PF13173.6 EDP45421.1 - 0.026 14.6 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EDP45421.1 - 0.05 12.8 0.0 0.09 11.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 EDP45421.1 - 0.067 12.8 0.0 0.23 11.1 0.0 1.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Cdc6_C PF09079.11 EDP45421.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain SR-25 PF10500.9 EDP45421.1 - 3 7.4 18.2 2 8.0 6.2 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 EDP45422.1 - 9.9e-28 95.8 14.6 2.4e-06 28.2 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 EDP45422.1 - 4e-09 35.7 2.0 0.0089 14.7 0.0 4.9 4 1 1 5 5 5 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EDP45422.1 - 5.4e-05 23.4 0.0 4.4 7.7 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain APG6_N PF17675.1 EDP45422.1 - 1.2 9.7 9.2 2.4 8.7 9.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region GET2 PF08690.10 EDP45423.1 - 1.2e-07 31.7 3.6 1e-05 25.4 1.7 2.6 2 1 0 2 2 2 2 GET complex subunit GET2 TRIQK PF15168.6 EDP45423.1 - 0.13 12.1 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family DNA_topoisoIV PF00521.20 EDP45424.1 - 2.6e-123 412.1 0.0 4.3e-123 411.4 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EDP45424.1 - 2e-50 170.4 1.8 2.3e-50 170.1 0.1 2.0 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EDP45424.1 - 4.1e-25 88.3 0.0 1e-24 86.9 0.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EDP45424.1 - 4.3e-14 53.0 0.0 9.5e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EDP45424.1 - 1.5e-07 31.5 0.0 4.3e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Toprim domain ECH_1 PF00378.20 EDP45425.1 - 1.5e-70 237.4 1.6 1.8e-70 237.1 1.6 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EDP45425.1 - 2.4e-33 116.1 1.0 3e-33 115.7 1.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EDP45425.1 - 0.0049 16.8 0.8 0.15 12.0 0.0 2.5 2 1 0 2 2 2 1 Peptidase family S49 CobA_CobO_BtuR PF02572.15 EDP45425.1 - 0.07 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP RRM_1 PF00076.22 EDP45426.1 - 0.02 14.7 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phosphodiest PF01663.22 EDP45427.1 - 8.6e-10 38.7 0.1 1.4e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EDP45427.1 - 0.00066 19.1 0.2 0.0011 18.4 0.2 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EDP45427.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Sulfatase PCI PF01399.27 EDP45428.1 - 2.8e-06 27.8 0.0 4.6e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 PCI domain TPR_16 PF13432.6 EDP45428.1 - 0.0079 16.8 1.4 0.0079 16.8 1.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ATP-synt_DE PF00401.20 EDP45428.1 - 0.031 14.5 0.5 0.11 12.8 0.5 2.0 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain TPR_14 PF13428.6 EDP45428.1 - 0.053 14.4 0.4 0.053 14.4 0.4 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDP45428.1 - 0.08 13.1 0.9 0.25 11.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DNA_pol_E_B PF04042.16 EDP45429.1 - 3.8e-34 117.9 0.4 5.6e-34 117.3 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EDP45430.1 - 2.1e-33 115.2 0.0 2.6e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Dus PF01207.17 EDP45431.1 - 1.7e-46 158.7 0.0 3.5e-33 115.0 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 EDP45431.1 - 3.7e-10 39.4 7.6 9.7e-05 22.1 0.2 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EDP45431.1 - 1e-06 28.5 7.8 0.0074 16.2 0.3 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EDP45431.1 - 5.5e-06 27.0 2.0 0.033 14.9 0.6 2.5 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EDP45431.1 - 1.7e-05 24.7 11.3 0.005 16.9 2.6 2.5 2 0 0 2 2 2 2 Zinc finger domain tRNA-synt_1g PF09334.11 EDP45432.1 - 4.7e-150 499.7 0.1 5.8e-150 499.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.20 EDP45432.1 - 6.6e-11 42.2 1.2 1.6e-10 41.0 1.2 1.6 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1 PF00133.22 EDP45432.1 - 2.6e-08 32.6 0.4 2.8e-05 22.6 0.0 2.9 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) zinc-ribbons_6 PF07191.12 EDP45432.1 - 0.41 10.7 7.3 0.94 9.5 7.3 1.6 1 0 0 1 1 1 0 zinc-ribbons HypA PF01155.19 EDP45432.1 - 6.2 6.9 5.7 8.8 6.4 0.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EDP45432.1 - 6.5 6.9 9.6 24 5.0 7.1 2.2 1 1 1 2 2 2 0 Double zinc ribbon IPP-2 PF04979.14 EDP45433.1 - 4.5e-07 30.7 1.7 5.2e-07 30.5 1.7 1.1 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Lipase_chap PF03280.14 EDP45433.1 - 0.047 13.6 3.2 0.053 13.5 3.2 1.1 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein DNA_pol_phi PF04931.13 EDP45434.1 - 3.5 5.6 5.5 4.8 5.2 5.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi PHD PF00628.29 EDP45435.1 - 5.8e-08 32.5 16.2 1e-07 31.8 16.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EDP45435.1 - 6.7 6.4 10.7 11 5.7 10.7 1.3 1 0 0 1 1 1 0 PHD-finger Herpes_capsid PF06112.11 EDP45435.1 - 7.3 6.6 21.8 24 5.0 21.8 1.9 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein BP28CT PF08146.12 EDP45436.1 - 4.1e-30 104.7 1.4 1.1e-28 100.0 0.3 3.1 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EDP45436.1 - 4.7e-14 52.7 0.2 4.7e-14 52.7 0.2 5.8 6 1 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 XPG_I PF00867.18 EDP45437.1 - 2.4e-07 31.0 0.1 9.1e-07 29.1 0.1 2.0 1 1 0 1 1 1 1 XPG I-region NUDIX PF00293.28 EDP45438.1 - 4e-14 52.8 6.3 6.9e-14 52.0 6.3 1.4 1 1 0 1 1 1 1 NUDIX domain Ribosomal_L7Ae PF01248.26 EDP45440.1 - 4.4e-22 77.6 0.2 7e-22 77.0 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ish1 PF10281.9 EDP45441.1 - 3.8e-52 174.3 23.1 3.4e-11 43.2 2.8 6.7 7 0 0 7 7 7 6 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EDP45441.1 - 1.1e-07 31.5 0.1 0.012 15.4 0.0 4.6 5 0 0 5 5 5 2 HeH/LEM domain SAP PF02037.27 EDP45441.1 - 0.00083 19.0 0.0 1.2 9.0 0.0 3.9 4 0 0 4 4 4 1 SAP domain LEM PF03020.15 EDP45441.1 - 0.0022 17.5 0.0 6.6 6.4 0.0 3.9 4 0 0 4 4 4 1 LEM domain ABATE PF07336.11 EDP45441.1 - 0.03 15.0 0.3 25 5.6 0.1 3.9 3 1 0 3 3 3 0 Putative stress-induced transcription regulator Thymopoietin PF08198.11 EDP45441.1 - 0.051 13.2 0.0 0.44 10.2 0.0 2.6 3 0 0 3 3 3 0 Thymopoietin protein SMC_N PF02463.19 EDP45442.1 - 0.00066 19.2 0.9 0.0014 18.1 0.9 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EDP45442.1 - 0.001 19.3 0.9 0.0032 17.7 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF4972 PF16342.5 EDP45442.1 - 0.36 10.5 3.9 1.3 8.8 0.2 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Pox_A_type_inc PF04508.12 EDP45442.1 - 6 6.9 16.1 3.2 7.7 1.0 5.0 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat AAA_23 PF13476.6 EDP45443.1 - 8.3e-18 65.6 0.0 8.9e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EDP45443.1 - 5.8e-09 35.7 0.0 6.7e-09 35.5 0.0 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EDP45443.1 - 1.1e-07 32.0 0.0 1.2e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EDP45443.1 - 4.8e-05 23.3 0.0 5.6e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP45443.1 - 0.00012 21.8 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EDP45443.1 - 0.00048 20.7 0.0 0.00056 20.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EDP45443.1 - 0.0008 19.8 0.0 0.00086 19.7 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_13 PF13166.6 EDP45443.1 - 0.0011 17.7 0.0 0.0011 17.7 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 EDP45443.1 - 0.024 14.2 0.0 0.025 14.2 0.0 1.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EDP45443.1 - 0.029 14.6 0.0 0.033 14.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDP45443.1 - 0.03 14.5 0.1 0.037 14.2 0.1 1.1 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EDP45443.1 - 0.032 14.1 0.0 0.038 13.9 0.0 1.1 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 EDP45443.1 - 0.043 13.4 0.1 0.052 13.1 0.1 1.1 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EDP45443.1 - 0.046 13.2 0.0 0.059 12.9 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_25 PF13481.6 EDP45443.1 - 0.049 13.2 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDP45443.1 - 0.068 12.9 0.0 0.082 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EDP45443.1 - 0.12 12.0 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 EDP45443.1 - 0.13 12.1 0.0 0.15 11.9 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 EDP45443.1 - 0.16 10.7 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class FtsK_SpoIIIE PF01580.18 EDP45443.1 - 0.16 11.3 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family DHHC PF01529.20 EDP45444.1 - 2.3e-29 102.2 5.4 2.3e-29 102.2 5.4 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase PSI PF01437.25 EDP45444.1 - 0.031 14.8 5.7 0.031 14.8 5.7 3.0 3 0 0 3 3 3 0 Plexin repeat ThiF PF00899.21 EDP45445.1 - 1.5e-18 67.0 0.0 3.3e-18 65.9 0.0 1.5 1 1 0 1 1 1 1 ThiF family zf-RRN7 PF11781.8 EDP45446.1 - 0.0012 18.5 0.2 0.0033 17.1 0.2 1.8 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HTH_31 PF13560.6 EDP45447.1 - 0.047 14.0 0.0 0.088 13.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain TPR_MLP1_2 PF07926.12 EDP45448.1 - 1.5e-09 38.0 27.1 1.5e-09 38.0 27.1 14.9 8 4 3 13 13 13 3 TPR/MLP1/MLP2-like protein SCP2 PF02036.17 EDP45449.1 - 0.05 14.1 0.0 0.075 13.5 0.0 1.4 1 1 0 1 1 1 0 SCP-2 sterol transfer family CHD5 PF04420.14 EDP45450.1 - 8.1e-39 133.0 0.3 1.1e-38 132.6 0.3 1.2 1 0 0 1 1 1 1 CHD5-like protein GATase_4 PF13230.6 EDP45451.1 - 0.0012 17.8 0.0 0.0014 17.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EDP45451.1 - 0.018 15.2 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase domain Paf67 PF10255.9 EDP45452.1 - 1.2e-125 419.7 8.1 5.7e-95 318.7 6.8 2.1 1 1 1 2 2 2 2 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EDP45452.1 - 0.0035 17.3 0.0 0.02 15.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 EDP45452.1 - 0.0093 15.9 0.2 0.028 14.4 0.1 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family TPR_1 PF00515.28 EDP45452.1 - 0.02 14.7 0.0 0.15 11.9 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF202 PF02656.15 EDP45453.1 - 9.8e-05 22.7 2.1 9.8e-05 22.7 2.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PIRT PF15099.6 EDP45453.1 - 0.012 15.2 0.1 0.022 14.3 0.1 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF3290 PF11694.8 EDP45453.1 - 4.9 7.1 6.6 1.3 9.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Chordopox_A13L PF05961.11 EDP45453.1 - 6.1 7.2 0.0 6.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein EMP24_GP25L PF01105.24 EDP45454.1 - 5.9e-45 153.4 0.0 7e-45 153.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3339 PF11820.8 EDP45454.1 - 0.056 13.7 0.1 0.056 13.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3339) Jagunal PF07086.12 EDP45454.1 - 0.1 12.7 1.9 1.3 9.0 0.1 2.1 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis DUF4972 PF16342.5 EDP45454.1 - 0.19 11.4 2.1 0.17 11.6 0.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) DUF4519 PF15012.6 EDP45454.1 - 0.64 10.2 2.9 0.3 11.3 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Voltage_CLC PF00654.20 EDP45455.1 - 1.6e-73 248.0 28.0 5.6e-45 154.1 11.4 3.1 3 1 1 4 4 4 2 Voltage gated chloride channel CBS PF00571.28 EDP45455.1 - 2.2e-10 40.8 0.0 1.9e-05 25.0 0.1 2.6 2 0 0 2 2 2 2 CBS domain SAC3_GANP PF03399.16 EDP45456.1 - 3.6e-97 325.3 0.0 5.9e-97 324.6 0.0 1.4 1 0 0 1 1 1 1 SAC3/GANP family DLIC PF05783.11 EDP45457.1 - 1.9e-26 93.0 0.1 2.8e-22 79.2 0.1 3.7 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) MMR_HSR1 PF01926.23 EDP45457.1 - 0.022 14.8 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EDP45457.1 - 0.08 13.3 0.4 0.26 11.7 0.5 2.0 1 1 0 1 1 1 0 AAA ATPase domain PPR_2 PF13041.6 EDP45458.1 - 1.5e-22 79.5 0.0 4.8e-07 29.9 0.0 7.5 8 1 1 9 9 9 3 PPR repeat family PPR PF01535.20 EDP45458.1 - 2.1e-18 65.2 0.0 0.07 13.4 0.0 11.6 14 0 0 14 14 14 4 PPR repeat PPR_3 PF13812.6 EDP45458.1 - 1.3e-14 54.0 0.0 0.00013 22.0 0.0 4.9 4 1 2 6 6 6 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 EDP45458.1 - 5.4e-10 38.8 0.0 0.09 12.5 0.0 6.4 7 0 0 7 7 7 2 PPR repeat PPR_long PF17177.4 EDP45458.1 - 2.1e-09 37.1 2.7 0.11 11.9 0.0 5.7 3 1 3 6 6 6 3 Pentacotripeptide-repeat region of PRORP TPR_4 PF07721.14 EDP45458.1 - 0.027 15.1 17.4 55 4.8 0.9 8.5 7 0 0 7 7 7 0 Tetratricopeptide repeat YEATS PF03366.16 EDP45459.1 - 5.8e-39 131.9 0.0 8.3e-39 131.4 0.0 1.2 1 0 0 1 1 1 1 YEATS family SMK-1 PF04802.15 EDP45460.1 - 7.9e-61 205.2 5.4 1.6e-60 204.3 5.4 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Arm_2 PF04826.13 EDP45460.1 - 0.00047 19.7 0.3 0.2 11.1 0.0 2.3 2 0 0 2 2 2 2 Armadillo-like Rcd1 PF04078.13 EDP45460.1 - 0.13 11.5 2.6 0.15 11.3 0.1 2.3 3 1 0 3 3 3 0 Cell differentiation family, Rcd1-like Gln-synt_N PF03951.19 EDP45461.1 - 6.8e-13 48.2 0.0 1.1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_C PF00120.24 EDP45461.1 - 1.1e-12 47.6 0.0 1.9e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain cNMP_binding PF00027.29 EDP45462.1 - 7.6e-32 109.2 2.0 3.4e-18 65.5 0.0 4.6 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain Patatin PF01734.22 EDP45462.1 - 5.5e-16 59.4 10.9 1.4e-10 41.7 4.9 3.0 3 0 0 3 3 3 2 Patatin-like phospholipase Lactamase_B_6 PF16661.5 EDP45463.1 - 1.3e-48 165.0 0.0 2.1e-48 164.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EDP45463.1 - 1.4e-25 90.5 0.1 4.2e-21 75.9 0.0 3.4 2 1 1 3 3 3 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EDP45463.1 - 4.3e-16 59.2 0.0 2.3e-15 56.8 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 EDP45463.1 - 9.9e-06 25.4 0.0 7.7e-05 22.6 0.0 2.4 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EDP45463.1 - 0.0062 16.1 0.0 0.029 13.9 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EDP45463.1 - 0.035 14.1 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily DUF4589 PF15252.6 EDP45463.1 - 1.3 9.0 6.0 0.14 12.2 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4589) Ribosomal_L3 PF00297.22 EDP45464.1 - 9.6e-22 77.5 1.6 8.8e-19 67.7 0.6 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 DSPc PF00782.20 EDP45465.1 - 2e-29 102.1 0.0 1.3e-22 80.0 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EDP45465.1 - 0.00028 20.6 0.0 0.00066 19.3 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Cpn60_TCP1 PF00118.24 EDP45468.1 - 7.5e-130 433.8 4.6 8.5e-65 219.3 0.8 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family G_glu_transpept PF01019.21 EDP45469.1 - 2.1e-149 498.6 0.0 2.4e-149 498.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PKcGMP_CC PF16808.5 EDP45470.1 - 0.011 15.6 0.1 0.011 15.6 0.1 6.1 6 0 0 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 EDP45470.1 - 0.045 14.0 74.1 0.21 11.8 17.6 4.3 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EDP45470.1 - 0.071 12.0 68.5 0.073 11.9 25.8 3.9 2 1 2 4 4 4 0 Spc7 kinetochore protein DUF4248 PF14053.6 EDP45470.1 - 0.32 11.0 1.6 31 4.7 0.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) GAS PF13851.6 EDP45470.1 - 1.4 8.3 64.4 0.41 10.0 10.8 5.7 3 1 2 5 5 5 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 EDP45470.1 - 1.4 9.3 64.1 5.8 7.3 30.5 3.9 2 1 2 4 4 4 0 Fez1 Fib_alpha PF08702.10 EDP45470.1 - 5.5 7.2 46.6 0.26 11.5 12.6 4.4 2 1 4 6 6 6 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.7 EDP45470.1 - 7 6.8 70.4 0.45 10.7 15.2 5.0 2 1 3 5 5 5 0 Tropomyosin like NGP1NT PF08153.12 EDP45471.1 - 4e-48 162.8 0.0 4e-48 162.8 0.0 1.9 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EDP45471.1 - 7.4e-18 64.7 0.0 5.6e-15 55.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EDP45471.1 - 5.7e-06 25.9 0.2 1.2e-05 24.9 0.1 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 EDP45471.1 - 0.00052 19.5 0.2 0.094 12.2 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EDP45471.1 - 0.0011 18.9 0.0 0.0032 17.4 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EDP45471.1 - 0.041 14.0 4.7 1.7 8.7 0.1 4.0 3 1 1 4 4 4 0 Dynamin family tRNA-synt_1d PF00750.19 EDP45472.1 - 7e-102 340.9 0.3 9.5e-102 340.5 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EDP45472.1 - 1.8e-19 70.1 0.5 7e-19 68.2 0.1 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain POT1 PF02765.17 EDP45472.1 - 0.0095 15.8 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 AKNA PF12443.8 EDP45473.1 - 0.013 16.2 0.1 0.013 16.2 0.1 3.3 3 0 0 3 3 3 0 AT-hook-containing transcription factor Lzipper-MIP1 PF14389.6 EDP45473.1 - 0.076 13.3 0.1 0.076 13.3 0.1 3.6 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Leu_zip PF15294.6 EDP45473.1 - 0.12 11.8 10.7 0.016 14.7 6.2 1.8 2 0 0 2 2 2 0 Leucine zipper DUF3602 PF12223.8 EDP45474.1 - 7.8e-12 45.6 9.5 1.6e-08 35.0 2.8 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) BRCT PF00533.26 EDP45475.1 - 0.059 13.8 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain VHS PF00790.19 EDP45476.1 - 1.6e-40 138.2 0.4 1.7e-38 131.7 0.0 2.6 3 0 0 3 3 3 2 VHS domain GAT PF03127.14 EDP45476.1 - 1.3e-19 70.3 0.1 1.3e-19 70.3 0.1 2.7 3 0 0 3 3 3 1 GAT domain Stm1_N PF09598.10 EDP45476.1 - 0.18 12.7 0.3 0.18 12.7 0.3 2.2 2 0 0 2 2 2 0 Stm1 GGA_N-GAT PF18308.1 EDP45476.1 - 1.3 8.7 9.4 0.52 10.0 0.1 3.7 4 0 0 4 4 4 0 GGA N-GAT domain PPR_2 PF13041.6 EDP45477.1 - 4.3e-11 42.8 0.0 0.0092 16.2 0.0 4.6 2 1 2 4 4 4 3 PPR repeat family PPR PF01535.20 EDP45477.1 - 8.3e-08 32.0 0.3 0.63 10.4 0.0 6.5 6 0 0 6 6 6 1 PPR repeat PPR_1 PF12854.7 EDP45477.1 - 5.3e-05 22.8 0.3 0.019 14.7 0.0 3.9 4 1 0 4 4 4 1 PPR repeat PPR_3 PF13812.6 EDP45477.1 - 0.00011 22.2 0.1 0.52 10.4 0.0 4.2 3 1 2 5 5 5 1 Pentatricopeptide repeat domain Ald_Xan_dh_C PF01315.22 EDP45477.1 - 0.05 14.0 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain TPR_14 PF13428.6 EDP45477.1 - 0.12 13.3 0.4 54 5.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat PIP5K PF01504.18 EDP45478.1 - 1.8e-37 129.1 0.5 1.3e-31 109.8 0.3 3.1 2 2 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EDP45478.1 - 7.9e-21 74.2 0.1 1.2e-20 73.6 0.1 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EDP45478.1 - 5.4e-17 61.7 10.4 5.4e-17 61.7 10.4 2.1 2 0 0 2 2 2 1 FYVE zinc finger zf-RING_5 PF14634.6 EDP45478.1 - 6.1 6.9 12.2 19 5.3 12.2 1.9 1 0 0 1 1 1 0 zinc-RING finger domain AAA PF00004.29 EDP45479.1 - 3.9e-44 150.3 0.0 6.2e-44 149.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP45479.1 - 6.8e-10 38.6 0.4 4.5e-09 36.0 0.2 2.2 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EDP45479.1 - 1.3e-08 35.5 0.0 8.9e-06 26.2 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EDP45479.1 - 1.7e-08 34.3 0.2 4.9e-08 32.8 0.2 1.9 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EDP45479.1 - 5.6e-08 32.9 0.1 2.4e-07 30.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EDP45479.1 - 1.5e-06 28.5 0.0 2.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDP45479.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EDP45479.1 - 4.4e-05 23.8 0.1 0.003 17.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EDP45479.1 - 0.00098 18.4 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EDP45479.1 - 0.0014 17.9 0.0 0.0024 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EDP45479.1 - 0.0014 19.1 0.0 0.0054 17.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EDP45479.1 - 0.0021 17.6 0.0 0.0044 16.5 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EDP45479.1 - 0.0039 16.6 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EDP45479.1 - 0.0044 17.0 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EDP45479.1 - 0.0049 16.6 0.0 0.0099 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 EDP45479.1 - 0.0076 16.0 0.1 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EDP45479.1 - 0.0089 15.7 0.1 0.041 13.6 0.1 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EDP45479.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EDP45479.1 - 0.01 16.2 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 EDP45479.1 - 0.014 15.4 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EDP45479.1 - 0.014 14.8 0.1 0.054 12.8 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 EDP45479.1 - 0.016 15.4 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EDP45479.1 - 0.017 15.3 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EDP45479.1 - 0.019 14.7 0.0 0.043 13.5 0.0 1.6 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 EDP45479.1 - 0.022 14.2 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 EDP45479.1 - 0.049 12.9 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 EDP45479.1 - 0.064 13.2 0.0 0.17 11.8 0.0 1.8 1 1 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 EDP45479.1 - 0.066 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EDP45479.1 - 0.084 12.4 0.1 0.19 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 EDP45479.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 EDP45479.1 - 0.15 12.4 0.2 0.29 11.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EDP45479.1 - 0.16 11.9 0.0 0.46 10.4 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EDP45479.1 - 0.19 11.5 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Clathrin PF00637.20 EDP45480.1 - 1e-200 657.7 26.6 1.4e-31 109.3 0.0 7.3 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EDP45480.1 - 1.6e-32 111.2 0.1 1.8e-31 107.8 0.1 2.8 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 EDP45480.1 - 4.3e-29 99.4 0.3 2.1e-05 24.6 0.0 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin-link PF09268.10 EDP45480.1 - 2.8e-10 39.4 0.2 8.6e-10 37.8 0.2 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 EDP45480.1 - 7.6e-06 25.2 4.7 0.063 12.3 0.0 4.6 5 0 0 5 5 5 2 Coatomer WD associated region TPR_1 PF00515.28 EDP45480.1 - 4e-05 23.2 2.2 25 4.9 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EDP45480.1 - 0.004 17.2 5.2 35 4.9 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat AMP-binding_C_2 PF14535.6 EDP45480.1 - 0.17 12.2 2.3 9.2 6.7 0.0 3.9 4 0 0 4 4 4 0 AMP-binding enzyme C-terminal domain TPR_14 PF13428.6 EDP45480.1 - 0.31 12.0 20.8 1.1e+02 4.1 0.0 10.2 12 1 1 13 13 12 0 Tetratricopeptide repeat TPR_8 PF13181.6 EDP45480.1 - 0.52 10.7 3.8 1.5e+02 3.0 0.2 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EDP45480.1 - 1.4 9.3 11.8 3.8 7.9 0.5 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Vps5 PF09325.10 EDP45481.1 - 0.0011 18.5 1.2 0.56 9.7 0.1 2.2 2 0 0 2 2 2 2 Vps5 C terminal like BLOC1_2 PF10046.9 EDP45481.1 - 0.015 15.6 1.0 0.15 12.4 0.0 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BAR PF03114.18 EDP45481.1 - 0.041 13.5 1.1 0.074 12.7 0.2 1.8 2 0 0 2 2 2 0 BAR domain ING PF12998.7 EDP45481.1 - 0.087 13.4 1.3 0.11 13.2 0.4 1.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding PX PF00787.24 EDP45482.1 - 3.3e-21 75.4 0.1 4.9e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 PX domain FYVE PF01363.21 EDP45483.1 - 2.2e-06 27.7 5.8 2.2e-06 27.7 5.8 2.3 2 1 0 2 2 2 1 FYVE zinc finger zf-NOSIP PF15906.5 EDP45483.1 - 2.7e-06 27.4 0.3 5.7e-06 26.4 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 EDP45483.1 - 1.6e-05 24.8 17.7 0.00087 19.3 9.9 2.4 2 0 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EDP45483.1 - 6.5e-05 22.7 19.5 0.00013 21.8 9.0 2.7 2 1 1 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EDP45483.1 - 0.00047 19.6 1.8 0.00047 19.6 1.8 2.9 1 1 2 3 3 3 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EDP45483.1 - 0.0011 19.0 2.0 0.0011 19.0 2.0 3.5 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EDP45483.1 - 0.0018 18.2 12.0 0.0018 18.2 12.0 3.6 2 2 1 3 3 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EDP45483.1 - 0.003 17.4 10.1 0.003 17.4 10.1 2.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EDP45483.1 - 0.0091 16.3 10.7 0.0091 16.3 10.7 2.4 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EDP45483.1 - 0.027 14.3 23.9 0.057 13.3 12.7 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DNA_RNApol_7kD PF03604.13 EDP45483.1 - 0.04 13.6 0.1 0.04 13.6 0.1 2.7 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-C3HC4_2 PF13923.6 EDP45483.1 - 0.42 10.5 21.9 0.087 12.7 10.7 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EDP45483.1 - 4.5 7.1 16.4 1.2 9.0 1.0 3.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 EDP45483.1 - 7.8 6.6 18.6 7.8 6.6 2.3 3.2 2 1 0 2 2 2 0 zinc-ribbons ETC_C1_NDUFA5 PF04716.14 EDP45484.1 - 9.2e-21 73.4 0.2 1.5e-20 72.7 0.2 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Sds3 PF08598.11 EDP45485.1 - 1.6e-06 28.3 0.1 2.6e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Sds3-like Orn_Arg_deC_N PF02784.16 EDP45486.1 - 2.1e-75 253.3 0.0 3.8e-75 252.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EDP45486.1 - 8.8e-19 67.6 0.0 1.2e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Zn_clus PF00172.18 EDP45487.1 - 2.2e-05 24.5 8.3 3.9e-05 23.7 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AFT PF08731.11 EDP45487.1 - 2.1 8.8 3.9 0.92 9.9 0.1 2.2 2 0 0 2 2 2 0 Transcription factor AFT Pkinase PF00069.25 EDP45488.1 - 2.8e-67 226.9 0.0 4.5e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45488.1 - 7.5e-34 117.2 0.0 1.2e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP45488.1 - 0.0037 16.6 0.0 0.0037 16.6 0.0 2.3 2 1 1 3 3 3 1 Kinase-like APH PF01636.23 EDP45488.1 - 0.02 14.8 0.0 0.02 14.8 0.0 3.2 3 1 0 3 3 3 0 Phosphotransferase enzyme family Complex1_LYR PF05347.15 EDP45489.1 - 6.1e-12 45.4 3.7 9e-12 44.9 1.5 2.0 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 EDP45489.1 - 0.0085 16.7 0.1 0.016 15.8 0.1 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Syntaxin_2 PF14523.6 EDP45489.1 - 0.13 12.7 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Syntaxin-like protein UPRTase PF14681.6 EDP45490.1 - 1e-38 132.9 0.0 1.1e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EDP45490.1 - 0.0026 17.3 0.0 0.0029 17.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Rxt3 PF08642.10 EDP45491.1 - 3.1e-21 76.5 0.0 7.9e-21 75.1 0.0 1.7 1 1 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EDP45491.1 - 0.0032 17.5 0.0 0.066 13.3 0.0 2.3 2 0 0 2 2 2 1 LCCL domain ESCRT-II PF05871.12 EDP45492.1 - 1.8e-42 144.9 0.0 2.3e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit LisH_TPL PF17814.1 EDP45492.1 - 0.05 13.3 0.0 3.3 7.4 0.0 3.0 3 0 0 3 3 3 0 LisH-like dimerisation domain WD40 PF00400.32 EDP45493.1 - 1.4e-22 79.5 0.1 7.3e-06 26.6 0.0 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat LSM PF01423.22 EDP45494.1 - 2.6e-13 49.5 0.0 3.3e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EDP45494.1 - 0.028 14.1 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Hfq protein CDC14 PF08045.11 EDP45495.1 - 5.7e-11 42.0 0.0 9.9e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Cell division control protein 14, SIN component UAA PF08449.11 EDP45496.1 - 5.2e-09 35.7 20.4 1.9e-07 30.6 3.7 2.1 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.20 EDP45496.1 - 1.6e-08 34.8 29.6 1.7e-07 31.5 7.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EDP45496.1 - 2.9e-05 23.6 1.6 2.9e-05 23.6 1.6 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family Porin_7 PF16956.5 EDP45496.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative general bacterial porin ABC_membrane_2 PF06472.15 EDP45497.1 - 7.6e-87 291.1 7.0 1e-86 290.7 7.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EDP45497.1 - 5.8e-16 59.3 0.0 1.5e-15 58.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter RuvB_N PF05496.12 EDP45497.1 - 0.0014 18.4 0.0 0.0056 16.4 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_21 PF13304.6 EDP45497.1 - 0.003 17.4 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EDP45497.1 - 0.025 14.3 0.1 0.094 12.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.29 EDP45497.1 - 0.028 14.9 0.0 0.06 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EDP45497.1 - 0.041 13.2 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EDP45497.1 - 0.048 14.2 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDP45497.1 - 0.071 13.6 0.2 0.3 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EDP45497.1 - 0.074 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EDP45497.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EDP45497.1 - 0.12 12.7 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EDP45497.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Zn_clus PF00172.18 EDP45500.1 - 1e-08 35.2 9.1 1.8e-08 34.3 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain K_channel_TID PF07941.11 EDP45500.1 - 3.7 8.1 14.1 0.41 11.1 4.9 3.1 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain Ribosomal_L23 PF00276.20 EDP45503.1 - 1.3e-05 25.5 0.0 2.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 OmdA PF13376.6 EDP45503.1 - 0.72 9.9 9.4 0.13 12.3 0.8 3.2 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated NIF PF03031.18 EDP45504.1 - 1.8e-51 174.0 0.0 3.1e-51 173.2 0.0 1.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Pkinase PF00069.25 EDP45505.1 - 7.1e-54 182.9 0.0 9.4e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EDP45505.1 - 9.8e-28 97.1 0.0 1.5e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EDP45505.1 - 6.7e-05 22.3 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EDP45505.1 - 0.029 14.3 0.0 0.1 12.5 0.0 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EDP45505.1 - 0.28 10.2 0.0 0.46 9.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2340 PF10209.9 EDP45506.1 - 2.8e-37 127.8 0.0 3.1e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) PXA PF02194.15 EDP45507.1 - 1.5e-17 64.2 0.5 1.2e-16 61.2 0.5 2.4 1 1 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EDP45507.1 - 7.9e-14 52.2 0.0 4.4e-13 49.8 0.1 2.3 2 0 0 2 2 2 1 Sorting nexin C terminal IL17 PF06083.11 EDP45507.1 - 0.014 15.8 0.3 0.037 14.5 0.3 1.7 1 0 0 1 1 1 0 Interleukin-17 XPG_I PF00867.18 EDP45508.1 - 2.9e-25 88.4 0.0 6.1e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EDP45508.1 - 3.4e-12 46.7 0.0 8.3e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EDP45508.1 - 3.4e-06 26.7 0.2 7.6e-05 22.3 0.2 2.4 1 1 0 1 1 1 1 XPG domain containing T7SS_ESX_EspC PF10824.8 EDP45508.1 - 2.9 8.4 9.3 1.2 9.7 1.0 3.6 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm NDUF_B8 PF05821.11 EDP45509.1 - 9.8e-05 22.3 2.6 0.0003 20.7 2.6 1.7 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Metallophos PF00149.28 EDP45510.1 - 2.6e-30 106.4 0.3 4.1e-30 105.8 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Homez PF11569.8 EDP45510.1 - 0.2 11.1 0.4 0.41 10.1 0.4 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MCM PF00493.23 EDP45511.1 - 1.8e-99 331.4 0.0 2.5e-99 330.9 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EDP45511.1 - 1.4e-38 131.6 0.0 2.5e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EDP45511.1 - 1.1e-30 107.0 24.1 1.1e-30 107.0 24.1 3.2 4 0 0 4 4 3 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EDP45511.1 - 6.3e-26 90.6 0.9 6.3e-26 90.6 0.9 3.0 4 0 0 4 4 3 1 MCM AAA-lid domain MCM_N PF14551.6 EDP45511.1 - 2.4e-12 47.4 0.1 1.5e-11 44.8 0.0 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EDP45511.1 - 1.7e-08 34.1 0.0 4.2e-07 29.5 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EDP45511.1 - 6.4e-07 29.4 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EDP45511.1 - 0.0012 18.7 0.0 0.0073 16.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EDP45511.1 - 0.011 15.5 0.1 0.098 12.4 0.1 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 EDP45511.1 - 0.035 14.5 0.0 0.098 13.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1931 PF09123.11 EDP45511.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) AAA_30 PF13604.6 EDP45511.1 - 0.11 12.1 0.8 0.37 10.5 0.2 2.0 2 0 0 2 2 2 0 AAA domain Zn_ribbon_2 PF12674.7 EDP45511.1 - 0.14 12.8 0.2 0.39 11.4 0.2 1.8 1 0 0 1 1 1 0 Putative zinc ribbon domain AAA_lid_2 PF17863.1 EDP45511.1 - 0.73 9.7 4.9 0.26 11.1 0.3 2.6 2 0 0 2 2 2 0 AAA lid domain ABC2_membrane PF01061.24 EDP45512.1 - 1.7e-76 256.4 56.9 1e-40 139.4 22.7 3.0 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EDP45512.1 - 4.6e-41 140.5 0.0 1.3e-18 67.9 0.0 3.4 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EDP45512.1 - 3.1e-21 75.1 0.0 3.1e-21 75.1 0.0 3.4 4 0 0 4 4 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EDP45512.1 - 4.9e-08 33.5 0.0 1.4e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EDP45512.1 - 8e-08 32.8 0.1 0.00022 21.7 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDP45512.1 - 1.8e-05 24.7 0.1 0.00017 21.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EDP45512.1 - 1.8e-05 25.0 0.1 0.038 14.2 0.0 3.0 2 1 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 EDP45512.1 - 2.8e-05 23.4 17.7 2.8e-05 23.4 17.7 4.0 5 1 0 5 5 5 2 ABC-2 family transporter protein AAA_25 PF13481.6 EDP45512.1 - 0.00014 21.5 0.2 0.0065 16.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 EDP45512.1 - 0.00028 20.5 0.7 0.09 12.4 0.3 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EDP45512.1 - 0.00055 19.6 0.8 0.081 12.7 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EDP45512.1 - 0.00068 19.6 0.0 0.34 10.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_21 PF13304.6 EDP45512.1 - 0.0014 18.5 0.0 0.47 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EDP45512.1 - 0.0015 19.1 0.0 0.45 11.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EDP45512.1 - 0.0054 17.0 0.0 1.8 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EDP45512.1 - 0.01 15.6 0.3 0.74 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EDP45512.1 - 0.011 15.9 0.2 0.7 10.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.19 EDP45512.1 - 0.011 15.1 0.0 0.31 10.4 0.0 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 EDP45512.1 - 0.036 13.8 0.2 2.1 8.0 0.1 2.8 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EDP45512.1 - 0.043 13.9 0.1 0.8 9.8 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase TsaE PF02367.17 EDP45512.1 - 0.059 13.4 0.2 0.4 10.7 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 EDP45512.1 - 0.065 13.7 0.1 9.4 6.7 0.1 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EDP45512.1 - 0.11 13.0 0.1 0.44 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EDP45512.1 - 0.12 12.8 0.0 4.4 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EDP45512.1 - 0.16 11.7 0.4 4.4 7.0 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EDP45512.1 - 0.22 10.8 0.0 4.6 6.4 0.0 2.1 2 0 0 2 2 2 0 Septin ABC2_membrane PF01061.24 EDP45513.1 - 1e-78 263.6 51.8 2.7e-41 141.3 14.6 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EDP45513.1 - 7.1e-37 127.0 0.0 2.3e-17 63.8 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EDP45513.1 - 2.8e-24 84.9 0.5 6.4e-20 70.9 0.0 3.0 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EDP45513.1 - 4.9e-12 46.3 0.0 1.5e-11 44.8 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EDP45513.1 - 8.3e-07 29.5 0.2 0.0016 18.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EDP45513.1 - 7.3e-06 26.0 0.0 5.4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EDP45513.1 - 0.0002 21.3 0.0 0.12 12.1 0.0 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EDP45513.1 - 0.0011 18.2 35.8 0.034 13.3 14.4 2.8 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_22 PF13401.6 EDP45513.1 - 0.0014 18.9 0.2 0.084 13.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EDP45513.1 - 0.0014 18.3 0.1 0.12 12.1 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EDP45513.1 - 0.0027 17.3 0.1 0.023 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EDP45513.1 - 0.0098 15.8 0.1 0.54 10.2 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 EDP45513.1 - 0.011 16.3 0.0 0.81 10.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain SMC_N PF02463.19 EDP45513.1 - 0.012 15.1 0.0 0.44 10.0 0.0 3.0 4 0 0 4 4 4 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 EDP45513.1 - 0.029 13.9 1.1 0.39 10.3 0.3 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EDP45513.1 - 0.051 14.0 0.1 11 6.4 0.1 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EDP45513.1 - 0.063 13.5 0.2 2.7 8.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EDP45513.1 - 0.063 13.4 0.1 1 9.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EDP45513.1 - 0.081 12.6 0.4 1.9 8.1 0.3 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EDP45513.1 - 0.12 12.4 0.1 0.48 10.4 0.1 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 EDP45513.1 - 0.21 11.4 0.0 0.52 10.1 0.0 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase Syntaxin-6_N PF09177.11 EDP45514.1 - 8.9e-14 51.8 4.2 4.3e-13 49.7 0.8 2.9 2 2 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EDP45514.1 - 1.9e-07 31.0 0.4 1.9e-07 31.0 0.4 2.3 3 0 0 3 3 2 1 SNARE domain HisKA PF00512.25 EDP45514.1 - 0.079 13.0 2.4 6.3 6.9 0.1 2.5 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain FlaC_arch PF05377.11 EDP45514.1 - 0.16 12.4 2.0 15 6.1 0.3 3.4 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) GGDEF_2 PF17853.1 EDP45514.1 - 0.24 11.7 2.8 9.5 6.5 0.6 2.2 1 1 1 2 2 2 0 GGDEF-like domain Spc7 PF08317.11 EDP45514.1 - 0.24 10.2 6.5 0.24 10.2 0.6 2.0 1 1 0 2 2 2 0 Spc7 kinetochore protein HisKA_3 PF07730.13 EDP45514.1 - 0.34 11.5 9.0 1.4 9.5 1.8 2.9 3 1 0 3 3 3 0 Histidine kinase T3SSipB PF16535.5 EDP45514.1 - 0.49 10.9 7.8 3.5 8.1 0.7 2.1 1 1 0 2 2 2 0 Type III cell invasion protein SipB EMP24_GP25L PF01105.24 EDP45514.1 - 0.61 10.0 2.4 3.8 7.4 0.3 2.4 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Gon7 PF08738.10 EDP45514.1 - 0.88 9.7 4.9 1.1 9.4 0.3 2.5 2 1 1 3 3 3 0 Gon7 family FliD_N PF02465.18 EDP45514.1 - 1.1 10.0 4.3 3.7 8.3 1.1 2.5 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF1690 PF07956.11 EDP45514.1 - 1.3 9.4 5.5 1.3 9.4 0.3 2.1 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Nup54 PF13874.6 EDP45514.1 - 9 6.4 9.7 40 4.3 4.9 2.6 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Thioredoxin_14 PF18402.1 EDP45515.1 - 1e-36 127.2 0.0 1e-35 124.0 0.0 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EDP45515.1 - 8.2e-32 109.6 0.0 3.2e-31 107.7 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_12 PF18400.1 EDP45515.1 - 9e-31 107.2 0.6 1.8e-30 106.2 0.6 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EDP45515.1 - 1.5e-21 76.7 0.5 7.3e-20 71.3 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_24 PF18404.1 EDP45515.1 - 0.0041 16.6 0.2 0.0072 15.8 0.2 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 EDP45515.1 - 0.014 15.4 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain CA_like PF10563.9 EDP45515.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative carbonic anhydrase Glyco_transf_24 PF18404.1 EDP45516.1 - 5.7e-56 189.9 0.7 6.4e-56 189.7 0.7 1.0 1 0 0 1 1 1 1 Glucosyltransferase 24 SNARE_assoc PF09335.11 EDP45517.1 - 5.6e-21 75.2 3.7 5.6e-21 75.2 3.7 2.3 3 0 0 3 3 3 1 SNARE associated Golgi protein LtrA PF06772.11 EDP45519.1 - 4.1e-31 108.5 29.1 7.7e-18 64.8 20.3 2.0 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) 5_nucleotid_C PF02872.18 EDP45520.1 - 7e-31 107.6 0.0 1.2e-29 103.6 0.0 2.1 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EDP45520.1 - 0.12 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase HMG_box PF00505.19 EDP45521.1 - 5e-21 74.9 10.0 1.1e-14 54.6 1.9 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EDP45521.1 - 6.8e-17 61.8 9.0 4.6e-13 49.5 2.1 2.2 2 0 0 2 2 2 2 HMG-box domain MlaC PF05494.12 EDP45521.1 - 0.00015 21.6 1.7 0.0059 16.4 0.1 2.3 2 0 0 2 2 2 1 MlaC protein PEPcase_2 PF14010.6 EDP45521.1 - 0.026 13.0 0.5 0.25 9.8 0.0 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxylase DUF1413 PF07205.11 EDP45521.1 - 0.027 14.5 0.6 0.16 12.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1413) Strep_SA_rep PF06696.11 EDP45521.1 - 0.034 14.1 1.1 0.057 13.4 0.1 2.0 2 0 0 2 2 2 0 Streptococcal surface antigen repeat JmjC PF02373.22 EDP45521.1 - 0.072 13.5 1.4 2.6 8.5 0.2 2.2 2 0 0 2 2 2 0 JmjC domain, hydroxylase DUF2489 PF10675.9 EDP45521.1 - 0.11 12.4 1.7 3.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) DUF2115 PF09888.9 EDP45521.1 - 0.13 12.8 1.1 0.27 11.8 0.1 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) BILBO1_N PF18281.1 EDP45521.1 - 0.47 10.9 4.7 0.11 12.9 0.8 2.0 2 2 0 2 2 2 0 BILBO1 N-terminal domain PGI PF00342.19 EDP45522.1 - 2.3e-227 755.4 0.0 2.7e-227 755.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase KH_1 PF00013.29 EDP45523.1 - 0.00021 21.0 0.0 0.00066 19.5 0.0 1.8 2 0 0 2 2 2 1 KH domain Pyocin_S PF06958.12 EDP45523.1 - 0.021 15.4 2.9 0.021 15.4 2.9 2.0 1 1 1 2 2 2 0 S-type Pyocin Podoplanin PF05808.11 EDP45524.1 - 0.59 10.2 7.5 0.99 9.5 7.5 1.3 1 0 0 1 1 1 0 Podoplanin DUF1387 PF07139.11 EDP45524.1 - 0.85 9.3 4.9 1.2 8.7 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Pex14_N PF04695.13 EDP45524.1 - 1.6 9.3 7.2 3.6 8.2 7.2 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SDA1 PF05285.12 EDP45524.1 - 3 7.2 7.6 4.1 6.7 7.6 1.1 1 0 0 1 1 1 0 SDA1 DUF1744 PF08490.12 EDP45526.1 - 4.1e-100 335.2 0.0 5.1e-69 232.8 0.0 2.5 2 1 1 3 3 3 2 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EDP45526.1 - 3.4e-73 246.7 0.0 5e-73 246.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EDP45526.1 - 3.2e-12 45.9 0.2 7.5e-11 41.4 0.2 3.0 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EDP45526.1 - 6.8e-09 35.7 0.1 1.7e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EDP45526.1 - 0.00023 21.2 0.0 0.00075 19.5 0.0 1.9 1 0 0 1 1 1 1 RNase_H superfamily GFP PF01353.22 EDP45526.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Green fluorescent protein Rpr2 PF04032.16 EDP45526.1 - 1.3 9.4 3.3 7.8 6.9 0.0 2.8 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain ParA PF10609.9 EDP45527.1 - 3.5e-87 291.9 0.0 4.6e-87 291.5 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDP45527.1 - 1.6e-08 34.7 0.0 5.7e-08 32.9 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 EDP45527.1 - 2.7e-05 23.5 0.0 5.5e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Anion-transporting ATPase AAA_25 PF13481.6 EDP45527.1 - 0.00029 20.4 0.0 0.00049 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 EDP45527.1 - 0.0013 18.7 0.2 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 EDP45527.1 - 0.0016 18.0 0.0 0.0027 17.2 0.0 1.4 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ PcrB PF01884.17 EDP45527.1 - 0.0049 16.4 0.0 0.0074 15.8 0.0 1.2 1 0 0 1 1 1 1 PcrB family Fer4_NifH PF00142.18 EDP45527.1 - 0.0063 16.0 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RsgA_GTPase PF03193.16 EDP45527.1 - 0.016 15.1 0.1 0.039 13.9 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase CLP1_P PF16575.5 EDP45527.1 - 0.051 13.4 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EDP45527.1 - 0.067 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EDP45527.1 - 0.087 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 EDP45527.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MipZ PF09140.11 EDP45527.1 - 0.16 11.2 0.0 0.43 9.8 0.0 1.6 2 0 0 2 2 2 0 ATPase MipZ Beach PF02138.18 EDP45528.1 - 1.5e-112 375.5 0.0 2.1e-112 375.0 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EDP45528.1 - 3.2e-05 23.9 0.0 7.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH FYVE_2 PF02318.16 EDP45528.1 - 0.00026 21.2 3.3 0.00056 20.1 3.3 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger DUF4704 PF15787.5 EDP45528.1 - 0.00041 19.7 4.6 0.011 15.0 0.1 3.8 4 1 0 4 4 4 1 Domain of unknown function (DUF4704) FYVE PF01363.21 EDP45528.1 - 0.02 15.0 5.6 0.052 13.7 5.6 1.6 1 0 0 1 1 1 0 FYVE zinc finger WD40 PF00400.32 EDP45528.1 - 0.23 12.4 3.4 0.7 10.9 0.2 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat RRM_1 PF00076.22 EDP45529.1 - 1e-10 41.3 0.0 1.7e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EDP45529.1 - 3.2e-05 24.4 1.1 5.1e-05 23.7 1.1 1.3 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Uds1 PF15456.6 EDP45529.1 - 0.00057 20.1 0.3 0.00073 19.7 0.3 1.1 1 0 0 1 1 1 1 Up-regulated During Septation ALC PF17527.2 EDP45529.1 - 0.78 9.4 2.8 2.9 7.5 1.3 2.0 2 0 0 2 2 2 0 Phage ALC protein UcrQ PF02939.16 EDP45530.1 - 2.1e-30 104.5 1.7 2.3e-30 104.3 1.7 1.0 1 0 0 1 1 1 1 UcrQ family zinc_ribbon_10 PF10058.9 EDP45531.1 - 9.2e-16 57.3 0.3 1.1e-12 47.5 0.0 2.4 2 0 0 2 2 2 2 Predicted integral membrane zinc-ribbon metal-binding protein Wzy_C_2 PF11846.8 EDP45531.1 - 0.13 12.2 0.3 0.28 11.1 0.1 1.7 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Zn_ribbon_SprT PF17283.2 EDP45531.1 - 0.87 9.5 4.0 1.5 8.8 0.6 2.6 2 0 0 2 2 2 0 SprT-like zinc ribbon domain MgtE PF01769.16 EDP45531.1 - 2.3 8.6 5.4 0.73 10.2 2.2 1.7 2 0 0 2 2 2 0 Divalent cation transporter NAD_kinase PF01513.21 EDP45532.1 - 6.4e-39 133.9 0.0 7.6e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase Histone PF00125.24 EDP45533.1 - 5.8e-51 172.3 2.5 6.5e-51 172.1 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EDP45533.1 - 1.7e-05 25.1 0.0 2.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EDP45533.1 - 2.4e-05 24.4 0.5 3.7e-05 23.8 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EDP45533.1 - 0.00027 21.5 1.4 0.00032 21.3 1.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EDP45533.1 - 0.0073 16.6 0.1 0.014 15.7 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EDP45533.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated WD40 PF00400.32 EDP45534.1 - 5.6e-24 84.0 14.1 3.1e-06 27.8 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45534.1 - 5.9e-19 68.2 5.5 8.6e-08 32.4 0.8 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EDP45534.1 - 1.2e-07 31.8 0.2 3.2e-05 23.9 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A GMP_synt_C PF00958.22 EDP45535.1 - 6.5e-43 144.7 0.1 1.3e-42 143.7 0.1 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EDP45535.1 - 6.6e-38 130.4 0.0 1.5e-37 129.2 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EDP45535.1 - 1.8e-11 43.7 0.1 2.4e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EDP45535.1 - 1.8e-08 34.4 0.0 3.8e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 EDP45535.1 - 0.00023 20.1 0.3 0.00055 18.8 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase ThiI PF02568.14 EDP45535.1 - 0.0011 18.6 0.0 0.0024 17.5 0.0 1.5 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 EDP45535.1 - 0.0014 18.2 0.0 0.031 13.8 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 EDP45535.1 - 0.023 14.0 0.1 0.052 12.8 0.1 1.6 1 0 0 1 1 1 0 Arginosuccinate synthase sCache_like PF16736.5 EDP45535.1 - 0.029 14.5 0.1 0.064 13.3 0.1 1.5 1 0 0 1 1 1 0 Single Cache-like WD40 PF00400.32 EDP45536.1 - 5.4e-15 55.5 3.3 2.4e-05 25.0 0.2 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45536.1 - 0.021 15.1 0.0 0.27 11.6 0.0 2.7 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EDP45536.1 - 0.042 12.5 0.1 0.22 10.2 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cys_Met_Meta_PP PF01053.20 EDP45537.1 - 1.9e-24 85.9 0.0 2.7e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EDP45537.1 - 0.00073 18.8 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Rnk_N PF14760.6 EDP45537.1 - 0.25 11.9 2.9 2 9.0 0.5 2.6 2 0 0 2 2 2 0 Rnk N-terminus SNARE PF05739.19 EDP45538.1 - 6.9e-17 61.2 0.1 2.1e-16 59.7 0.1 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EDP45538.1 - 0.00011 21.9 12.3 0.00085 19.0 1.9 2.9 2 1 1 3 3 3 2 Syntaxin Syntaxin-5_N PF11416.8 EDP45538.1 - 0.00063 18.9 0.0 0.0016 17.6 0.0 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain DUF16 PF01519.16 EDP45538.1 - 0.059 13.9 4.4 0.25 11.9 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EDP45538.1 - 0.067 13.8 3.9 0.8 10.4 0.1 3.2 2 1 1 3 3 3 0 SlyX Baculo_PEP_C PF04513.12 EDP45538.1 - 0.094 12.8 6.7 2.7 8.0 0.2 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EDP45538.1 - 0.14 11.0 3.8 0.9 8.4 0.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF148 PF02520.17 EDP45538.1 - 0.24 11.5 9.4 4.1 7.6 0.3 3.4 3 1 0 3 3 3 0 Domain of unknown function DUF148 Prominin PF05478.11 EDP45538.1 - 0.24 9.3 1.8 1 7.2 0.1 2.1 2 0 0 2 2 2 0 Prominin FlaC_arch PF05377.11 EDP45538.1 - 0.27 11.7 1.5 0.94 9.9 0.1 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EDP45538.1 - 0.3 11.1 5.3 0.41 10.7 0.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FliJ PF02050.16 EDP45538.1 - 0.34 11.1 11.4 0.11 12.8 2.5 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein T2SSF PF00482.23 EDP45538.1 - 0.61 10.0 3.9 0.53 10.3 0.2 2.5 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F zf-C4H2 PF10146.9 EDP45538.1 - 1.2 9.4 7.3 13 6.0 0.3 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein KxDL PF10241.9 EDP45538.1 - 1.2 9.4 12.2 24 5.3 1.1 4.0 3 2 0 3 3 3 0 Uncharacterized conserved protein Wbp11 PF09429.10 EDP45538.1 - 3.3 8.2 4.9 34 4.9 0.2 3.2 2 2 2 4 4 4 0 WW domain binding protein 11 Spectrin PF00435.21 EDP45538.1 - 5.4 7.6 8.1 4.7 7.8 0.5 3.1 2 1 1 3 3 3 0 Spectrin repeat Sdh_cyt PF01127.22 EDP45539.1 - 9.4e-20 70.9 2.6 1.3e-19 70.4 2.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit GCP_N_terminal PF17681.1 EDP45540.1 - 2e-63 214.8 0.0 3.6e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EDP45540.1 - 4.4e-39 134.8 9.5 4.4e-39 134.8 9.5 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal TP_methylase PF00590.20 EDP45541.1 - 5.1e-40 137.7 0.3 1e-39 136.7 0.3 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 EDP45541.1 - 4.3e-14 52.8 0.0 8.8e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 EDP45541.1 - 2e-08 33.5 0.1 4.8e-08 32.3 0.1 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 EDP45541.1 - 4.2e-08 32.7 1.3 6e-07 29.0 0.5 2.2 2 0 0 2 2 2 1 Sirohaem biosynthesis protein C-terminal SAM_decarbox PF01536.16 EDP45542.1 - 8.6e-131 436.2 0.0 1.1e-130 435.8 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Peptidase_M16_C PF05193.21 EDP45543.1 - 1.4e-17 64.3 0.0 6.1e-14 52.4 0.0 3.0 2 1 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EDP45543.1 - 8e-08 32.4 0.1 2.6e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Xan_ur_permease PF00860.20 EDP45544.1 - 1.2e-18 67.0 23.8 1.5e-17 63.4 23.8 2.3 1 1 0 1 1 1 1 Permease family Asp PF00026.23 EDP45545.1 - 7.4e-25 88.0 0.1 2.3e-24 86.4 0.1 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EDP45545.1 - 0.013 15.2 0.0 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EDP45545.1 - 0.017 15.7 0.0 7.8 7.1 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EDP45545.1 - 0.023 15.3 0.0 1.7 9.3 0.0 2.7 2 0 0 2 2 2 0 Aspartyl protease Ricin_B_lectin PF00652.22 EDP45547.1 - 0.00067 19.9 0.3 0.13 12.5 0.0 2.2 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain DUF4766 PF15973.5 EDP45548.1 - 0.02 15.4 0.1 0.025 15.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4766) UPF0506 PF11703.8 EDP45548.1 - 0.26 11.7 5.6 0.082 13.3 3.0 1.6 1 1 0 1 1 1 0 UPF0506 Chorismate_bind PF00425.18 EDP45549.1 - 6.1e-90 301.3 0.0 8.3e-90 300.8 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EDP45549.1 - 2.8e-26 92.4 0.0 8.6e-26 90.8 0.0 1.9 1 1 0 1 1 1 1 Anthranilate synthase component I, N terminal region PRP21_like_P PF12230.8 EDP45550.1 - 8.8e-36 123.8 1.5 4.2e-35 121.6 1.5 2.1 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EDP45550.1 - 2.2e-35 120.4 3.0 7.2e-19 67.5 0.2 2.5 2 0 0 2 2 2 2 Surp module zf-Di19 PF05605.12 EDP45550.1 - 0.044 14.1 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding RNF220 PF15926.5 EDP45550.1 - 0.066 12.8 1.3 0.22 11.1 1.3 1.9 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Glyco_hydro_46 PF01374.18 EDP45550.1 - 9.6 5.8 6.2 1.3 8.6 1.6 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 46 PalH PF08733.10 EDP45551.1 - 0.08 11.9 12.3 0.24 10.4 12.2 1.7 1 1 1 2 2 2 0 PalH/RIM21 ADK PF00406.22 EDP45552.1 - 1.9e-42 144.9 0.0 2.5e-42 144.5 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDP45552.1 - 3e-21 76.3 0.0 5.4e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EDP45552.1 - 1.4e-13 50.6 0.0 2.6e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EDP45552.1 - 9e-06 26.3 0.0 1.7e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EDP45552.1 - 7.3e-05 23.0 0.0 0.0002 21.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EDP45552.1 - 0.011 15.9 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EDP45552.1 - 0.049 12.9 0.0 0.08 12.2 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Ploopntkinase3 PF18751.1 EDP45552.1 - 0.17 11.8 0.1 1.6 8.6 0.0 2.0 1 1 1 2 2 2 0 P-loop Nucleotide Kinase3 V_ATPase_I PF01496.19 EDP45553.1 - 0 1033.4 0.0 0 1033.2 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TEX13 PF15186.6 EDP45553.1 - 0.013 15.2 1.2 0.024 14.3 1.2 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family VCBS PF13517.6 EDP45554.1 - 6e-18 65.2 7.1 0.00077 20.0 0.4 5.0 4 1 1 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EDP45554.1 - 3.5e-11 43.0 4.0 0.013 15.6 0.0 5.5 5 0 0 5 5 5 5 FG-GAP repeat Apt1 PF10351.9 EDP45555.1 - 1.3e-99 334.2 0.1 2.3e-99 333.4 0.1 1.4 1 0 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 EDP45555.1 - 9.6e-36 123.2 0.0 1.8e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EDP45555.1 - 6.8e-29 100.8 0.0 3.1e-28 98.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_WPPW PF10359.9 EDP45555.1 - 1.2e-28 100.3 5.4 2.3e-18 66.3 4.5 2.3 1 1 1 2 2 2 2 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.9 EDP45555.1 - 1.2e-18 67.7 1.3 2.9e-18 66.5 0.2 2.4 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain AT_hook PF02178.19 EDP45556.1 - 0.021 14.6 1.8 0.021 14.6 1.8 3.9 3 0 0 3 3 3 0 AT hook motif GP40 PF11025.8 EDP45556.1 - 0.11 12.2 0.4 0.22 11.3 0.4 1.4 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium tRNA_Me_trans PF03054.16 EDP45557.1 - 1.5e-88 297.0 0.0 1.7e-88 296.8 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Ras PF00071.22 EDP45559.1 - 2.2e-52 176.9 0.0 2.7e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EDP45559.1 - 5.5e-19 68.6 0.0 8e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EDP45559.1 - 3.5e-06 26.6 0.0 5.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EDP45559.1 - 0.04 13.4 0.0 0.18 11.3 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain ISG65-75 PF11727.8 EDP45561.1 - 2 7.5 14.7 3.8 6.6 14.7 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein Asn_synthase PF00733.21 EDP45562.1 - 8.9e-89 298.6 4.4 5.7e-55 187.4 0.6 2.9 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EDP45562.1 - 1.1e-36 125.4 0.0 1.9e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EDP45562.1 - 2.3e-30 105.5 0.0 1.6e-29 102.8 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EDP45562.1 - 5.7e-07 29.2 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EDP45562.1 - 0.0029 16.8 0.0 0.0059 15.8 0.0 1.5 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 EDP45562.1 - 0.083 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC WD40 PF00400.32 EDP45563.1 - 6.7e-07 29.9 5.6 0.17 12.8 0.0 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EDP45563.1 - 1.4e-05 25.3 0.0 0.028 14.7 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EDP45563.1 - 0.045 14.2 0.4 11 6.6 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain Hira PF07569.11 EDP45563.1 - 0.071 12.8 0.2 0.79 9.4 0.0 2.5 2 0 0 2 2 2 0 TUP1-like enhancer of split Mog1 PF04603.12 EDP45564.1 - 5.9e-37 127.1 0.0 7e-37 126.9 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein AlaDh_PNT_N PF05222.15 EDP45565.1 - 1.9e-27 96.2 0.0 2.8e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EDP45565.1 - 0.00014 21.2 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_1 PF00175.21 EDP45566.1 - 2.8e-29 102.0 0.0 4.8e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EDP45566.1 - 7.2e-27 93.6 0.1 1.6e-26 92.5 0.1 1.5 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EDP45566.1 - 1e-05 25.7 0.0 0.00011 22.4 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Abhydrolase_3 PF07859.13 EDP45567.1 - 4.3e-45 154.2 0.0 3.6e-35 121.7 0.0 3.2 3 0 0 3 3 3 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EDP45567.1 - 2.7e-09 36.4 0.0 2.8e-08 33.0 0.0 2.0 2 0 0 2 2 2 1 Steryl acetyl hydrolase AXE1 PF05448.12 EDP45567.1 - 0.022 13.4 0.0 0.037 12.7 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) COesterase PF00135.28 EDP45567.1 - 0.06 12.2 0.1 0.32 9.8 0.0 1.9 2 0 0 2 2 2 0 Carboxylesterase family Shugoshin_C PF07557.11 EDP45569.1 - 6.4e-08 32.2 4.4 6.4e-08 32.2 4.4 3.8 4 0 0 4 4 4 1 Shugoshin C terminus Smg4_UPF3 PF03467.15 EDP45571.1 - 4.2e-41 140.9 0.3 4.2e-41 140.9 0.3 3.2 2 1 0 2 2 2 1 Smg-4/UPF3 family Actin PF00022.19 EDP45572.1 - 8.8e-29 100.3 0.1 2.4e-14 52.8 0.0 2.0 2 0 0 2 2 2 2 Actin LRR_6 PF13516.6 EDP45573.1 - 3.4e-07 29.8 0.1 1 9.6 0.1 5.7 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 EDP45573.1 - 0.0034 17.7 0.0 6.2 7.8 0.0 4.3 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 EDP45573.1 - 0.014 15.8 0.0 7.5 7.1 0.1 3.4 3 2 0 3 3 3 0 Leucine Rich repeats (2 copies) MA3 PF02847.17 EDP45574.1 - 1.1e-29 102.7 0.3 2.4e-29 101.6 0.3 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 EDP45574.1 - 3.1e-13 49.9 0.0 1.2e-12 48.0 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain MRP-S33 PF08293.11 EDP45574.1 - 0.076 13.3 0.1 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit S27 CENP-B_dimeris PF09026.10 EDP45574.1 - 4.6 7.7 12.3 15 6.0 12.3 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain KH_6 PF15985.5 EDP45575.1 - 1.2e-09 38.4 0.0 2.4e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 EDP45575.1 - 2.6e-09 36.7 0.1 5.1e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region PTS_EIIA_1 PF00358.20 EDP45575.1 - 0.086 12.6 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 UQ_con PF00179.26 EDP45576.1 - 3.8e-15 55.8 0.1 4.1e-15 55.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EDP45576.1 - 0.037 13.7 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Thiolase_N PF00108.23 EDP45577.1 - 2.2e-90 302.6 0.9 3.6e-90 301.8 0.3 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EDP45577.1 - 1e-33 115.6 1.4 4e-33 113.7 0.6 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EDP45577.1 - 1.9e-07 31.0 2.0 5.8e-06 26.1 0.3 3.1 2 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EDP45577.1 - 0.015 15.2 0.7 0.41 10.5 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III AAA PF00004.29 EDP45579.1 - 1.3e-40 138.9 0.0 2.7e-40 137.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EDP45579.1 - 3.1e-06 26.9 0.0 8.2e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EDP45579.1 - 3.5e-05 24.1 0.0 0.0053 17.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EDP45579.1 - 7.2e-05 22.8 0.1 0.00035 20.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EDP45579.1 - 0.00033 19.9 0.0 0.00067 18.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EDP45579.1 - 0.0004 20.8 0.1 0.025 15.0 0.0 2.7 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EDP45579.1 - 0.00059 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EDP45579.1 - 0.0067 16.2 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EDP45579.1 - 0.017 15.4 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EDP45579.1 - 0.018 15.2 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EDP45579.1 - 0.018 14.5 0.0 0.041 13.4 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region Herpes_capsid PF06112.11 EDP45579.1 - 0.031 14.3 2.3 0.058 13.5 2.3 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein AAA_18 PF13238.6 EDP45579.1 - 0.044 14.3 0.0 0.16 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EDP45579.1 - 0.058 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EDP45579.1 - 0.067 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 EDP45579.1 - 0.075 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EDP45579.1 - 0.079 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 EDP45579.1 - 0.089 12.7 0.0 11 5.9 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 EDP45579.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 EDP45579.1 - 0.13 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EDP45579.1 - 0.14 11.8 0.1 0.8 9.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EDP45579.1 - 0.17 12.3 0.0 0.5 10.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 EDP45580.1 - 1.4e-104 348.4 0.0 2.1e-104 347.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EDP45580.1 - 2.5e-47 159.7 0.0 4.4e-47 158.9 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EDP45580.1 - 8.3e-14 51.9 2.3 2.1e-13 50.6 2.3 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DHBP_synthase PF00926.19 EDP45581.1 - 2e-56 190.6 0.0 2.2e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Mitofilin PF09731.9 EDP45582.1 - 4.4e-92 309.9 15.7 5.2e-92 309.7 15.7 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein ApoLp-III PF07464.11 EDP45582.1 - 0.042 13.9 9.1 0.85 9.7 2.0 3.4 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) KLRAQ PF10205.9 EDP45582.1 - 0.057 13.6 4.2 0.16 12.3 4.2 1.8 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF2362 PF10154.9 EDP45582.1 - 0.11 11.4 1.8 0.17 10.8 1.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) DUF1104 PF06518.11 EDP45582.1 - 0.88 10.0 8.4 9.2 6.7 3.9 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) DUF4404 PF14357.6 EDP45582.1 - 2.3 8.9 13.8 0.056 14.1 2.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) MAP7 PF05672.11 EDP45582.1 - 3.4 7.3 16.6 6.7 6.4 16.6 1.4 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family IMS PF00817.20 EDP45583.1 - 4.7e-34 117.5 0.0 1.1e-33 116.3 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EDP45583.1 - 2.2e-15 56.8 0.6 6.3e-15 55.3 0.6 1.9 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain BRCT PF00533.26 EDP45583.1 - 1.5e-08 34.9 0.0 3.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EDP45583.1 - 1.6e-07 31.6 0.0 3.1e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain UBM PF14377.6 EDP45583.1 - 0.00017 20.9 2.3 0.001 18.4 0.6 2.7 2 0 0 2 2 2 1 Ubiquitin binding region PTCB-BRCT PF12738.7 EDP45583.1 - 0.00062 19.7 0.0 0.0014 18.5 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain ADK PF00406.22 EDP45584.1 - 2.9e-59 199.5 0.1 3.5e-59 199.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EDP45584.1 - 2.4e-23 83.1 0.3 6.6e-23 81.6 0.1 1.8 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EDP45584.1 - 1.8e-16 59.8 0.0 5.7e-16 58.2 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EDP45584.1 - 6e-07 29.7 0.0 1.3e-06 28.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EDP45584.1 - 0.00015 22.3 0.0 0.00075 20.1 0.0 2.0 2 1 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EDP45584.1 - 0.024 14.3 0.1 3.8 7.1 0.0 3.0 2 1 1 3 3 3 0 Thymidylate kinase AAA_5 PF07728.14 EDP45584.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EDP45584.1 - 0.029 14.8 0.1 0.066 13.6 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EDP45584.1 - 0.031 13.6 0.1 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin ParA PF10609.9 EDP45585.1 - 9.8e-89 297.0 0.0 1.2e-88 296.7 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EDP45585.1 - 2.9e-06 27.4 0.1 0.00025 21.1 0.3 3.0 3 1 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 EDP45585.1 - 1.3e-05 24.6 1.1 0.00029 20.1 0.4 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 EDP45585.1 - 8.3e-05 22.2 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 EDP45585.1 - 0.00034 20.6 0.1 0.085 12.8 0.1 2.2 2 0 0 2 2 2 2 AAA domain MipZ PF09140.11 EDP45585.1 - 0.0085 15.4 0.3 0.048 12.9 0.3 2.1 1 1 0 1 1 1 1 ATPase MipZ AAA_16 PF13191.6 EDP45585.1 - 0.012 16.1 0.3 0.074 13.4 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_26 PF13500.6 EDP45585.1 - 0.044 13.6 0.2 1 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EDP45585.1 - 0.048 13.6 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 EDP45585.1 - 0.086 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain CBP_BcsQ PF06564.12 EDP45585.1 - 0.11 11.9 0.2 5.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ TPR_2 PF07719.17 EDP45586.1 - 8.1e-18 63.1 35.6 0.00018 21.4 0.1 9.8 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 EDP45586.1 - 5.6e-15 54.4 20.4 0.0026 17.5 0.1 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 EDP45586.1 - 9.3e-13 47.9 42.6 0.00012 22.5 0.8 10.1 7 2 3 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 EDP45586.1 - 8.8e-09 34.9 10.0 0.0016 18.1 0.1 7.6 7 1 2 9 9 9 2 TPR repeat TPR_8 PF13181.6 EDP45586.1 - 9.7e-09 34.8 12.3 0.52 10.7 0.0 7.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EDP45586.1 - 1.5e-07 31.6 33.5 0.008 16.5 0.9 7.9 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EDP45586.1 - 2.1e-07 31.5 53.2 0.001 19.7 2.4 8.8 7 1 1 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 EDP45586.1 - 2.5e-06 27.1 26.8 0.07 13.2 0.1 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EDP45586.1 - 3.2e-05 24.0 11.9 9.6 6.8 0.0 8.4 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 EDP45586.1 - 3.2e-05 24.4 32.5 0.17 12.4 0.4 8.2 8 1 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EDP45586.1 - 0.0029 17.7 1.7 0.0029 17.7 1.7 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EDP45586.1 - 0.0095 16.1 20.7 0.16 12.2 0.1 5.9 5 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EDP45586.1 - 0.034 14.0 22.8 0.12 12.2 0.3 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EDP45586.1 - 4.2 8.2 23.3 1.2 9.9 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Fer4 PF00037.27 EDP45587.1 - 5e-14 51.4 16.5 1.3e-08 34.3 4.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EDP45587.1 - 2.9e-12 47.0 9.6 4.8e-12 46.3 9.6 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EDP45587.1 - 3e-10 40.9 6.5 3.1e-05 24.8 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EDP45587.1 - 2.5e-09 37.1 4.9 0.00068 19.7 0.5 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EDP45587.1 - 9.8e-09 35.3 9.6 1.7e-08 34.5 9.6 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EDP45587.1 - 1.1e-08 35.0 22.1 4.3e-06 26.8 12.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EDP45587.1 - 2.2e-08 34.4 18.6 6.9e-06 26.4 10.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EDP45587.1 - 2.1e-06 27.4 12.6 0.0042 17.1 2.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EDP45587.1 - 4.4e-06 26.8 9.8 0.00032 21.0 1.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 EDP45587.1 - 5.6e-06 26.2 17.7 0.0074 16.3 4.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EDP45587.1 - 0.00035 21.1 12.5 0.0046 17.5 12.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EDP45587.1 - 0.0055 17.2 14.7 0.36 11.4 3.6 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 EDP45587.1 - 0.035 14.3 5.1 1.8 8.8 0.4 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_3 PF12798.7 EDP45587.1 - 0.1 13.6 16.7 0.24 12.4 5.2 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 EDP45587.1 - 0.12 12.5 9.7 1.4 9.2 1.2 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 EDP45587.1 - 1.1 10.1 13.6 1.7 9.5 2.1 2.7 2 1 2 4 4 4 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 EDP45587.1 - 1.9 9.3 13.1 3.2 8.5 4.8 2.9 2 1 0 2 2 2 0 4Fe-4S single cluster domain ETF_QO PF05187.13 EDP45587.1 - 2.3 8.4 5.7 5.5 7.2 2.0 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Ydr279_N PF17745.1 EDP45589.1 - 1.4e-09 38.1 0.0 2.1e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_H2-Ydr279 PF09468.10 EDP45589.1 - 0.00029 21.0 0.0 0.00085 19.5 0.0 1.6 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF455 PF04305.14 EDP45590.1 - 1.5e-91 306.4 0.0 1.8e-91 306.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) 2Fe-2S_thioredx PF01257.19 EDP45592.1 - 7.3e-56 188.1 0.5 1.5e-55 187.1 0.3 1.6 2 0 0 2 2 2 1 Thioredoxin-like [2Fe-2S] ferredoxin adh_short PF00106.25 EDP45593.1 - 2.8e-15 56.3 0.1 1.7e-14 53.7 0.1 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EDP45593.1 - 1.3e-05 24.8 0.2 0.00016 21.4 0.2 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EDP45593.1 - 5.2e-05 23.2 0.2 0.00083 19.3 0.1 2.2 2 0 0 2 2 2 1 KR domain Eno-Rase_NADH_b PF12242.8 EDP45593.1 - 0.13 12.1 0.1 0.44 10.3 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RNA_polI_A34 PF08208.11 EDP45594.1 - 4.5e-13 49.8 12.4 8.7e-12 45.6 12.4 2.1 1 1 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.5 EDP45594.1 - 6.8e-05 22.7 0.0 0.00037 20.3 0.0 2.1 1 1 1 2 2 2 1 Coilin N-terminus Tom37 PF10568.9 EDP45595.1 - 1.9e-08 34.7 0.1 4.1e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EDP45595.1 - 3e-08 33.3 0.0 6.4e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EDP45595.1 - 0.003 18.3 0.1 0.0089 16.8 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 EDP45595.1 - 0.014 15.4 0.1 0.039 14.0 0.1 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF913 PF06025.12 EDP45595.1 - 0.095 11.7 1.2 0.15 11.0 1.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 EDP45595.1 - 0.16 12.2 0.4 0.25 11.5 0.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4357 PF14267.6 EDP45596.1 - 0.094 12.7 0.0 0.3 11.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) tRNA-synt_1g PF09334.11 EDP45597.1 - 5.5e-92 308.5 0.0 1.1e-91 307.6 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EDP45597.1 - 3.5e-15 55.3 3.0 1.5e-08 33.4 0.1 2.6 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EDP45597.1 - 1.6e-08 34.3 0.0 0.0038 16.6 0.0 2.8 2 1 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EDP45597.1 - 0.035 13.0 0.0 0.069 12.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (K) HLH PF00010.26 EDP45598.1 - 4.7e-07 29.7 0.0 1.6e-06 28.0 0.0 1.9 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain ApbA PF02558.16 EDP45599.1 - 2.9e-27 95.2 0.0 3.9e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EDP45599.1 - 6.1e-23 81.4 0.0 2.1e-22 79.6 0.0 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal Pyr_redox PF00070.27 EDP45599.1 - 0.18 12.4 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase tRNA-synt_2 PF00152.20 EDP45600.1 - 1.6e-69 234.4 0.1 3.8e-69 233.2 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EDP45600.1 - 2.6e-12 46.4 0.0 4.2e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA-synt_2d PF01409.20 EDP45600.1 - 0.00055 19.5 2.0 0.091 12.2 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) DDHD PF02862.17 EDP45601.1 - 0.018 15.2 0.9 0.018 15.2 0.9 2.4 2 1 0 2 2 2 0 DDHD domain Zip PF02535.22 EDP45601.1 - 0.87 8.7 6.7 1.8 7.7 6.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 EDP45601.1 - 0.89 8.2 3.2 1.4 7.5 3.2 1.3 1 0 0 1 1 1 0 Reduced folate carrier SID-1_RNA_chan PF13965.6 EDP45601.1 - 2.3 6.5 4.9 4 5.7 4.9 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BNR_3 PF13859.6 EDP45601.1 - 8.9 5.5 9.0 0.46 9.7 3.2 1.7 2 0 0 2 2 2 0 BNR repeat-like domain HA2 PF04408.23 EDP45602.1 - 2.1e-17 63.3 0.4 4.6e-17 62.3 0.4 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EDP45602.1 - 7.9e-14 51.8 0.0 2.2e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EDP45602.1 - 2.8e-12 47.0 0.0 5.3e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SCA7 PF08313.12 EDP45603.1 - 8.3e-28 96.1 0.0 8.3e-28 96.1 0.0 1.9 2 0 0 2 2 2 1 SCA7, zinc-binding domain BRF1 PF07741.13 EDP45603.1 - 0.059 13.7 2.8 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain HA2 PF04408.23 EDP45603.1 - 0.08 13.2 0.4 3.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Helicase associated domain (HA2) zf-TRAF PF02176.18 EDP45603.1 - 0.088 13.5 1.0 0.49 11.1 0.2 2.1 2 0 0 2 2 2 0 TRAF-type zinc finger DUF1776 PF08643.10 EDP45604.1 - 0.0016 17.9 0.1 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EDP45604.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DASH_Dad2 PF08654.10 EDP45605.1 - 6.9e-26 90.6 0.6 8.3e-26 90.3 0.6 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 Synaptonemal_3 PF15191.6 EDP45605.1 - 0.14 12.0 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 DivIC PF04977.15 EDP45605.1 - 0.56 10.0 4.8 0.19 11.5 2.1 1.6 2 0 0 2 2 2 0 Septum formation initiator DUF2034 PF10356.9 EDP45606.1 - 6.2e-14 51.8 2.2 4.6e-12 45.8 2.2 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EDP45606.1 - 1.4e-06 28.3 0.0 8.7e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 Restriction endonuclease Ribosomal_S30 PF04758.14 EDP45607.1 - 1.5e-29 101.9 7.8 1.7e-29 101.8 7.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 S10_plectin PF03501.15 EDP45608.1 - 2.3e-41 139.8 0.2 2.7e-41 139.5 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain zf-Tim10_DDP PF02953.15 EDP45609.1 - 6.4e-12 44.9 0.1 7.6e-12 44.7 0.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Asp PF00026.23 EDP45610.1 - 1.1e-70 238.6 0.1 1.3e-70 238.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EDP45610.1 - 9.1e-12 45.6 0.4 4.5e-06 27.0 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EDP45610.1 - 0.00016 21.5 0.0 0.00064 19.5 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal DnaJ_C PF01556.18 EDP45611.1 - 2.9e-27 95.6 0.0 4.1e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EDP45611.1 - 5.4e-23 80.9 0.9 9.1e-23 80.2 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EDP45611.1 - 9.3e-15 54.8 13.6 1.5e-14 54.1 13.6 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EDP45611.1 - 5.8e-06 26.2 4.1 0.03 14.3 0.5 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DZR PF12773.7 EDP45611.1 - 0.025 14.6 7.6 0.086 12.9 7.8 1.8 1 1 0 1 1 1 0 Double zinc ribbon A2L_zn_ribbon PF08792.10 EDP45611.1 - 0.039 13.7 8.2 0.39 10.5 0.0 4.1 4 1 1 5 5 5 0 A2L zinc ribbon domain Cytochrome_CBB3 PF13442.6 EDP45611.1 - 0.085 13.2 0.0 0.29 11.5 0.0 1.9 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III Prok-RING_4 PF14447.6 EDP45611.1 - 0.17 11.8 3.6 2.1 8.3 1.1 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zinc_ribbon_9 PF14369.6 EDP45611.1 - 0.17 12.2 10.1 5.1 7.5 0.1 4.2 3 1 1 4 4 4 0 zinc-ribbon DUF5351 PF17302.2 EDP45611.1 - 0.93 9.7 17.6 2.9 8.2 0.7 4.3 4 0 0 4 4 4 0 Family of unknown function (DUF5351) Cytochrom_c3_2 PF14537.6 EDP45611.1 - 2.2 8.8 7.2 8.4 6.9 7.2 2.0 1 1 0 1 1 1 0 Cytochrome c3 Opy2 PF09463.10 EDP45611.1 - 3.3 8.1 12.8 7.6 6.9 1.7 2.5 2 0 0 2 2 2 0 Opy2 protein Zn_Tnp_IS1595 PF12760.7 EDP45611.1 - 5.9 7.0 15.8 2.4 8.2 1.4 3.2 2 1 1 3 3 3 0 Transposase zinc-ribbon domain TackOD1 PF18551.1 EDP45611.1 - 8.1 6.1 10.2 2.2 7.9 1.2 2.7 2 1 1 3 3 3 0 Thaumarchaeal output domain 1 FA_hydroxylase PF04116.13 EDP45612.1 - 5.2e-19 68.9 16.6 1.2e-18 67.7 16.6 1.7 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Response_reg PF00072.24 EDP45613.1 - 1.5e-20 73.4 0.1 4.8e-15 55.7 0.1 2.4 2 0 0 2 2 2 2 Response regulator receiver domain NCA2 PF08637.10 EDP45614.1 - 1.8e-78 263.7 0.0 2.4e-78 263.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 NMT_C PF02799.15 EDP45615.1 - 3.4e-74 248.9 0.0 8.2e-74 247.6 0.0 1.6 1 1 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EDP45615.1 - 6.1e-71 237.4 0.0 8.9e-71 236.9 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EDP45615.1 - 6.3e-05 23.0 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EDP45615.1 - 0.002 18.3 0.0 0.0051 17.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Torus PF16131.5 EDP45616.1 - 9.3e-06 26.3 0.3 2e-05 25.3 0.3 1.6 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 EDP45616.1 - 3.9e-05 23.6 4.1 3.9e-05 23.6 4.1 2.3 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_3 PF15663.5 EDP45616.1 - 0.00061 20.0 1.4 0.004 17.3 0.2 2.4 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH PF00642.24 EDP45616.1 - 0.0019 18.1 1.9 0.0019 18.1 1.9 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EDP45616.1 - 0.0051 16.6 1.6 0.016 15.0 1.6 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_1 PF00076.22 EDP45616.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EDP45616.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 Ribosomal_L31 PF01197.18 EDP45617.1 - 0.066 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L31 HECT PF00632.25 EDP45618.1 - 1.1e-95 320.6 0.0 1.5e-95 320.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EDP45618.1 - 3.5e-35 119.8 15.9 4.9e-12 45.7 1.9 3.6 3 0 0 3 3 3 3 WW domain C2 PF00168.30 EDP45618.1 - 3.5e-15 56.2 0.1 8.4e-15 54.9 0.1 1.6 1 0 0 1 1 1 1 C2 domain Nuc_sug_transp PF04142.15 EDP45619.1 - 1.1e-08 34.7 3.0 1.5e-08 34.2 3.0 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EDP45619.1 - 7.3e-06 25.4 7.2 1.1e-05 24.8 7.2 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EDP45619.1 - 5.3e-05 23.4 16.9 0.0098 16.1 6.0 3.2 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EDP45619.1 - 0.00059 19.3 7.0 0.0013 18.2 1.9 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family WCOR413 PF05562.11 EDP45619.1 - 0.028 14.3 2.5 0.051 13.5 2.5 1.4 1 0 0 1 1 1 0 Cold acclimation protein WCOR413 Hist_deacetyl PF00850.19 EDP45620.1 - 1.6e-77 261.0 0.0 1.9e-77 260.8 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Polysacc_deac_1 PF01522.21 EDP45621.1 - 2.3e-27 95.4 0.0 4.3e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_1 PF01522.21 EDP45622.1 - 4.9e-26 91.1 0.0 1.2e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Gcn1_N PF12074.8 EDP45623.1 - 3.9e-30 105.4 3.1 7.8e-30 104.4 0.1 3.1 2 1 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_EZ PF13513.6 EDP45623.1 - 9.9e-25 86.6 69.4 0.00031 21.2 0.1 21.4 21 3 3 24 24 23 8 HEAT-like repeat HEAT PF02985.22 EDP45623.1 - 4.4e-23 79.4 47.0 0.041 14.2 0.1 23.6 28 0 0 28 28 24 3 HEAT repeat HEAT_2 PF13646.6 EDP45623.1 - 3.9e-21 75.2 63.7 0.00045 20.5 4.9 14.9 9 3 7 17 17 15 9 HEAT repeats Cnd1 PF12717.7 EDP45623.1 - 1.4e-10 41.4 0.6 1.3 9.0 0.0 8.4 6 3 3 10 10 8 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EDP45623.1 - 5.9e-08 33.2 0.0 3.5 8.3 0.0 6.8 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd3 PF12719.7 EDP45623.1 - 2e-05 24.0 0.0 2.8 7.0 0.0 5.2 4 1 1 5 5 5 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 EDP45623.1 - 7.4e-05 22.4 4.6 1.4 8.4 0.0 7.1 7 1 1 8 8 8 2 CLASP N terminal RIX1 PF08167.12 EDP45623.1 - 0.00034 20.4 7.3 0.25 11.1 0.1 5.1 5 0 0 5 5 5 2 rRNA processing/ribosome biogenesis MMS19_N PF14500.6 EDP45623.1 - 0.0014 18.3 4.4 3 7.4 0.0 5.5 7 0 0 7 7 7 2 Dos2-interacting transcription regulator of RNA-Pol-II DUF3385 PF11865.8 EDP45623.1 - 0.0016 18.4 0.1 1.9 8.4 0.0 5.0 4 3 0 4 4 4 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 EDP45623.1 - 0.0033 16.6 11.0 2.6 7.1 0.1 6.9 6 1 0 6 6 6 1 RNAPII transcription regulator C-terminal Arm PF00514.23 EDP45623.1 - 0.011 15.7 8.0 10 6.3 0.0 7.1 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat Phage_TAC_9 PF10876.8 EDP45623.1 - 0.017 15.2 1.8 8.3 6.5 0.0 4.3 3 1 1 4 4 4 0 Phage tail assemb.y chaperone protein, TAC RTP1_C1 PF10363.9 EDP45623.1 - 0.018 15.2 0.2 30 4.8 0.0 5.8 6 0 0 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3437 PF11919.8 EDP45623.1 - 0.062 13.2 3.7 1.7 8.6 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3437) DUF4042 PF13251.6 EDP45623.1 - 0.078 12.7 5.3 14 5.4 0.2 5.0 5 1 0 5 5 5 0 Domain of unknown function (DUF4042) Adaptin_N PF01602.20 EDP45623.1 - 0.48 8.9 11.3 19 3.7 0.4 6.3 5 3 0 7 7 7 0 Adaptin N terminal region HEAT_PBS PF03130.16 EDP45623.1 - 2.5 9.0 22.1 1.2 10.0 0.7 8.6 8 0 0 8 8 6 0 PBS lyase HEAT-like repeat G-alpha PF00503.20 EDP45624.1 - 1.7e-112 376.1 0.3 2e-112 375.9 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EDP45624.1 - 1.7e-15 56.9 1.4 4.9e-10 39.1 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EDP45624.1 - 4.4e-05 22.9 0.6 0.11 11.8 0.1 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EDP45624.1 - 0.007 16.6 0.4 0.63 10.3 0.1 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EDP45624.1 - 0.046 13.3 0.0 0.78 9.2 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EDP45624.1 - 0.072 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3142 PF11340.8 EDP45624.1 - 0.14 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) MMR_HSR1 PF01926.23 EDP45624.1 - 0.15 12.1 0.0 9 6.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase FMN_dh PF01070.18 EDP45625.1 - 1.4e-113 379.5 0.0 1.7e-113 379.2 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EDP45625.1 - 1.7e-20 72.9 0.1 3.2e-20 72.0 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EDP45625.1 - 7.7e-05 22.0 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EDP45625.1 - 0.0005 19.2 0.1 0.0011 18.1 0.1 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EDP45625.1 - 0.031 13.6 0.0 3.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG NMO PF03060.15 EDP45625.1 - 0.087 12.2 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase Uso1_p115_head PF04869.14 EDP45626.1 - 4.9e-59 200.0 0.1 7.7e-57 192.8 0.0 3.4 2 2 1 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EDP45626.1 - 4.2e-07 30.4 12.0 4.2e-07 30.4 12.0 3.4 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region Arm_vescicular PF18770.1 EDP45626.1 - 3.3e-06 26.9 0.2 8.4e-06 25.6 0.2 1.7 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor MMS19_N PF14500.6 EDP45626.1 - 6e-06 26.0 1.8 0.00018 21.2 0.2 3.0 2 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II TFCD_C PF12612.8 EDP45626.1 - 0.063 13.1 2.2 0.15 11.8 0.1 2.7 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal XhlA PF10779.9 EDP45626.1 - 0.77 10.0 3.2 1.6 9.0 0.4 2.8 2 1 1 3 3 3 0 Haemolysin XhlA LHH PF14411.6 EDP45626.1 - 1 9.6 4.8 1.9 8.7 3.1 2.4 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH ADIP PF11559.8 EDP45626.1 - 2.7 8.1 27.3 7.3 6.7 5.3 3.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 EDP45626.1 - 3.4 7.7 12.9 2.9 8.0 1.6 3.8 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding CLZ PF16526.5 EDP45626.1 - 9.1 6.7 9.4 0.87 10.0 3.0 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PEARLI-4 PF05278.12 EDP45626.1 - 9.2 5.8 15.1 0.14 11.7 1.3 3.0 1 1 2 3 3 3 0 Arabidopsis phospholipase-like protein (PEARLI 4) WD40 PF00400.32 EDP45628.1 - 1.7e-06 28.7 13.4 0.081 13.8 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat RWD PF05773.22 EDP45629.1 - 1.6e-05 25.2 0.0 2.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 RWD domain HALZ PF02183.18 EDP45630.1 - 0.1 12.9 7.0 4.4 7.6 0.4 4.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper Turandot PF07240.11 EDP45630.1 - 0.4 10.7 1.9 16 5.6 0.2 2.7 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot Lipoprotein_6 PF01441.19 EDP45630.1 - 1.4 8.9 10.1 1.4 8.9 0.1 3.5 3 1 1 4 4 4 0 Lipoprotein FlaC_arch PF05377.11 EDP45630.1 - 2.2 8.7 9.4 12 6.4 0.1 4.4 3 1 2 5 5 5 0 Flagella accessory protein C (FlaC) PP2C_C PF07830.13 EDP45630.1 - 5.5 7.5 12.5 0.89 10.1 0.4 4.0 3 1 1 4 4 4 0 Protein serine/threonine phosphatase 2C, C-terminal domain Y_phosphatase PF00102.27 EDP45631.1 - 8e-54 182.7 0.0 2e-53 181.4 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EDP45631.1 - 6.3e-05 23.5 0.0 0.0038 17.7 0.0 2.8 2 1 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EDP45631.1 - 0.037 13.8 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EDP45631.1 - 0.073 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EDP45631.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Lectin_leg-like PF03388.13 EDP45632.1 - 3.6e-56 190.1 0.2 5.1e-56 189.6 0.2 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EDP45632.1 - 2.2e-13 50.7 0.3 3e-13 50.3 0.3 1.1 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EDP45632.1 - 0.00031 20.4 0.1 0.17 11.4 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain SRTM1 PF15872.5 EDP45632.1 - 0.0044 17.1 0.9 1.8 8.8 0.0 2.3 2 0 0 2 2 2 2 Serine-rich and transmembrane domain-containing protein 1 DUF3149 PF11346.8 EDP45632.1 - 0.1 12.2 4.3 0.38 10.4 4.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) RNase_T PF00929.24 EDP45633.1 - 2.9e-23 83.2 0.0 3.7e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Peptidase_C2 PF00648.21 EDP45634.1 - 3.7e-21 75.4 0.0 6.2e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease MIT PF04212.18 EDP45634.1 - 2.2e-06 27.6 0.8 3.7e-06 26.9 0.8 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pantoate_transf PF02548.15 EDP45635.1 - 5e-82 275.2 0.8 6.8e-78 261.6 0.2 2.1 2 0 0 2 2 2 2 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EDP45635.1 - 0.00036 20.1 0.3 0.00069 19.1 0.1 1.5 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase ABC_tran PF00005.27 EDP45636.1 - 7.7e-22 78.3 0.0 8.9e-14 52.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EDP45636.1 - 5.2e-08 33.0 0.1 0.0016 18.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EDP45636.1 - 0.00065 20.1 0.4 0.0038 17.6 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 EDP45636.1 - 0.0015 18.8 0.0 2.9 8.2 0.0 2.5 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EDP45636.1 - 0.0033 17.1 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EDP45636.1 - 0.0094 16.1 0.6 0.74 10.0 0.0 3.2 3 1 1 4 4 4 1 AAA domain AAA_24 PF13479.6 EDP45636.1 - 0.026 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EDP45636.1 - 0.035 14.6 0.0 0.062 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EDP45636.1 - 0.049 13.3 0.0 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EDP45636.1 - 0.052 13.5 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 NACHT domain Pox_A32 PF04665.12 EDP45636.1 - 0.055 12.9 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 EDP45636.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 EDP45636.1 - 0.17 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Glyco_hydro_31 PF01055.26 EDP45637.1 - 2.9e-58 198.1 0.0 3.4e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 EDP45637.1 - 4.8e-06 26.8 0.0 8.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Glyco_hydro_31 PF01055.26 EDP45638.1 - 1.5e-28 100.2 0.1 1.8e-28 100.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EDP45639.1 - 1.5e-18 66.9 0.0 2.6e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Galactose mutarotase-like eIF2A PF08662.11 EDP45640.1 - 2.6e-79 265.6 0.0 5.2e-77 258.1 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EDP45640.1 - 0.0019 18.5 0.0 11 6.5 0.0 4.1 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EDP45640.1 - 0.077 13.9 0.1 5.3 8.1 0.0 3.6 4 0 0 4 4 4 0 WD domain, G-beta repeat CDV3 PF15359.6 EDP45640.1 - 0.46 11.0 7.1 0.6 10.6 4.9 2.1 1 1 1 2 2 2 0 Carnitine deficiency-associated protein 3 PrmA PF06325.13 EDP45641.1 - 1.5e-10 41.0 0.0 2.3e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EDP45641.1 - 6.7e-09 36.3 0.1 2.7e-08 34.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EDP45641.1 - 1.9e-07 31.0 0.0 3.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EDP45641.1 - 5.8e-06 26.9 0.1 2.7e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EDP45641.1 - 0.00012 21.7 0.1 0.00021 20.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EDP45641.1 - 0.00021 20.7 0.0 0.0009 18.6 0.0 1.9 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EDP45641.1 - 0.00056 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EDP45641.1 - 0.00057 20.9 0.0 0.0014 19.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EDP45641.1 - 0.0024 18.6 0.0 0.0055 17.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EDP45641.1 - 0.0054 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EDP45641.1 - 0.0068 15.4 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 EDP45641.1 - 0.026 14.3 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EDP45641.1 - 0.057 13.2 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 EDP45641.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 EDP45641.1 - 0.068 13.2 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 EDP45641.1 - 0.089 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Chromo_shadow PF01393.19 EDP45642.1 - 8.9e-08 32.1 0.0 2.5e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 Chromo shadow domain Chromo PF00385.24 EDP45642.1 - 1.4e-07 31.3 0.2 2.3e-07 30.6 0.2 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Prok-TraM PF09228.10 EDP45642.1 - 1.3 9.5 3.4 5.8 7.3 0.1 2.7 1 1 1 2 2 2 0 Prokaryotic Transcriptional repressor TraM Peptidase_M28 PF04389.17 EDP45643.1 - 2.4e-32 112.3 0.0 3.5e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EDP45643.1 - 0.0023 17.6 0.0 0.016 14.9 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 GIDA_assoc PF13932.6 EDP45644.1 - 1.5e-57 195.2 0.0 2e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 GidA associated domain GIDA PF01134.22 EDP45644.1 - 6.3e-53 180.3 0.0 8.5e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Hormone_2 PF00123.20 EDP45645.1 - 0.13 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Peptide hormone PH PF00169.29 EDP45646.1 - 5e-08 33.4 0.0 8.5e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 PH domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Malassezia_globosa_CBS_7966-ASM18169v1/GCA_000181695.1_ASM18169v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Malassezia_globosa_CBS_7966-ASM18169v1/GCA_000181695.1_ASM18169v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Malassezia_globosa_CBS_7966-ASM18169v1/GCA_000181695.1_ASM18169v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Malassezia_globosa_CBS_7966-ASM18169v1/GCA_000181695.1_ASM18169v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 22:27:18 2019 # [ok]