# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF775 PF05603.12 ORX63332.1 - 4.1e-31 108.1 0.0 7.2e-29 100.7 0.0 2.8 1 1 0 1 1 1 1 Protein of unknown function (DUF775) zf-AN1 PF01428.16 ORX63337.1 - 7.4e-11 42.0 7.0 1.2e-10 41.4 7.0 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 ORX63337.1 - 0.11 12.9 4.4 0.18 12.2 4.4 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain UPF1_Zn_bind PF09416.10 ORX63337.1 - 0.21 11.6 2.1 0.32 10.9 2.1 1.3 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) IBR PF01485.21 ORX63337.1 - 0.56 10.5 5.5 1.2 9.4 5.5 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF2434 PF10361.9 ORX63344.1 - 0.07 12.1 2.9 1.5 7.7 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2434) Cation_ATPase_C PF00689.21 ORX63345.1 - 5.8e-45 153.2 10.3 5.8e-45 153.2 10.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ORX63345.1 - 1.1e-31 109.8 0.6 1.1e-31 109.8 0.6 2.8 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 ORX63345.1 - 4.1e-16 58.9 0.0 1.3e-15 57.2 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX63345.1 - 4.4e-16 59.8 0.0 1e-12 48.8 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX63345.1 - 1.4e-06 27.9 0.1 3.5e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX63345.1 - 0.00088 19.1 0.1 0.022 14.5 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Methyltransf_11 PF08241.12 ORX63346.1 - 8.8e-12 45.5 0.0 5.7e-11 42.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX63346.1 - 3.7e-11 43.6 0.0 1.6e-10 41.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX63346.1 - 1.4e-06 27.8 0.0 6.5e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX63346.1 - 1.4e-05 25.0 0.0 4.7e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX63346.1 - 0.0016 19.2 0.0 0.01 16.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 ORX63346.1 - 0.021 14.8 0.0 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase tRNA_U5-meth_tr PF05958.11 ORX63346.1 - 0.24 10.4 0.0 0.33 9.9 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase ANAPC16 PF17256.2 ORX63354.1 - 0.12 12.7 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 CMS1 PF14617.6 ORX63359.1 - 0.017 14.5 0.0 0.27 10.5 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit CHAP PF05257.16 ORX63359.1 - 0.12 12.9 0.5 0.27 11.8 0.5 1.5 1 0 0 1 1 1 0 CHAP domain DUF5614 PF18474.1 ORX63359.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5614) SurA_N_2 PF13623.6 ORX63359.1 - 0.19 11.6 0.1 0.28 11.0 0.1 1.2 1 0 0 1 1 1 0 SurA N-terminal domain DUF5489 PF17592.2 ORX63364.1 - 0.058 13.9 0.0 0.092 13.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5489) DDE_Tnp_4 PF13359.6 ORX63370.1 - 0.096 12.4 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease Peptidase_S10 PF00450.22 ORX63371.1 - 2.2e-111 373.3 0.0 2.6e-111 373.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Lipase PF00151.19 ORX63371.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Lipase Peptidase_S10 PF00450.22 ORX63372.1 - 2.9e-81 274.0 0.0 5.3e-64 217.2 0.1 3.1 1 1 1 2 2 2 2 Serine carboxypeptidase Abhydrolase_1 PF00561.20 ORX63372.1 - 0.05 13.2 0.7 0.13 11.9 0.7 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Cu-oxidase_2 PF07731.14 ORX63373.1 - 8.3e-36 122.7 4.9 2.5e-31 108.3 0.2 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX63373.1 - 2.2e-32 111.6 0.6 7.4e-28 97.0 0.2 2.8 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX63373.1 - 1.2e-24 87.2 0.0 3e-23 82.7 0.0 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ORX63373.1 - 0.001 19.1 0.0 3.3 7.9 0.0 3.2 3 1 0 3 3 3 2 Cupredoxin-like domain Aldedh PF00171.22 ORX63375.1 - 3.5e-17 62.1 0.0 5e-09 35.2 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Response_reg PF00072.24 ORX63401.1 - 7.2e-08 32.6 0.2 8.4e-08 32.4 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Aminotran_5 PF00266.19 ORX63402.1 - 0.0017 17.4 0.0 0.12 11.3 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class-V MCR_D PF02505.14 ORX63402.1 - 0.059 13.2 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein D Mei5 PF10376.9 ORX63402.1 - 0.11 12.3 0.1 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Double-strand recombination repair protein HAD_2 PF13419.6 ORX63413.1 - 7e-20 71.8 0.0 8.7e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX63413.1 - 6.1e-12 46.3 0.0 5.4e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX63413.1 - 6.9e-06 26.0 0.1 1.3e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ORX63413.1 - 0.0024 18.0 0.0 0.0084 16.2 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX63413.1 - 0.12 12.7 0.0 0.18 12.2 0.0 1.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Oxysterol_BP PF01237.18 ORX63415.1 - 3.4e-123 411.2 0.0 3.9e-123 411.0 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein FAM27 PF15832.5 ORX63415.1 - 0.14 12.8 4.2 1.3 9.6 1.5 2.4 2 0 0 2 2 2 0 FAM27 D and E protein family DDRGK PF09756.9 ORX63415.1 - 0.14 11.7 0.9 0.24 11.0 0.9 1.2 1 0 0 1 1 1 0 DDRGK domain T5orf172 PF10544.9 ORX63417.1 - 0.16 12.5 0.0 0.22 12.1 0.0 1.2 1 0 0 1 1 1 0 T5orf172 domain Mito_carr PF00153.27 ORX63423.1 - 1.3e-44 150.0 11.2 1.7e-20 72.7 0.5 4.0 1 1 3 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ORX63423.1 - 0.004 16.3 2.1 0.15 11.2 0.1 2.5 1 1 0 2 2 2 2 Gammaproteobacterial serine protease ubiquitin PF00240.23 ORX63425.1 - 2.6e-10 39.9 0.0 3.5e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX63425.1 - 0.0039 17.0 0.0 0.0056 16.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX63425.1 - 0.0068 17.0 0.0 0.0096 16.5 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain MIP PF00230.20 ORX63432.1 - 2e-35 122.6 11.4 2.3e-35 122.3 11.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein PIGA PF08288.12 ORX63433.1 - 8.4e-14 51.9 0.4 2.3e-13 50.5 0.1 1.8 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_trans_1_4 PF13692.6 ORX63433.1 - 2.6e-10 40.8 0.9 3e-09 37.4 0.9 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ORX63433.1 - 3e-10 39.9 0.1 2.7e-08 33.5 0.1 2.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX63433.1 - 7.9e-09 35.7 0.5 5.4e-07 29.8 0.5 2.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ORX63433.1 - 0.016 15.6 0.0 0.039 14.3 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 F-box-like PF12937.7 ORX63439.1 - 0.019 14.9 0.2 0.057 13.3 0.2 1.9 1 0 0 1 1 1 0 F-box-like SecM PF06558.12 ORX63439.1 - 0.058 13.5 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) Usp PF00582.26 ORX63440.1 - 2.6e-17 63.6 0.0 3e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family eRF1_1 PF03463.15 ORX63447.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 eRF1 domain 1 HAMP PF00672.25 ORX63448.1 - 3.8e-259 837.3 133.7 2.5e-08 34.2 0.9 44.0 41 2 1 42 42 41 34 HAMP domain Baculo_PEP_C PF04513.12 ORX63448.1 - 8.3e-47 158.8 293.0 4.1e-06 26.9 7.3 33.0 4 3 32 37 37 37 22 Baculovirus polyhedron envelope protein, PEP, C terminus APG17 PF04108.12 ORX63448.1 - 2.6e-45 155.3 31.4 0.0012 18.1 0.0 17.7 7 5 4 14 14 14 11 Autophagy protein Apg17 ApoLp-III PF07464.11 ORX63448.1 - 2.4e-37 128.3 168.3 0.00038 20.6 0.4 33.1 5 4 26 34 34 34 14 Apolipophorin-III precursor (apoLp-III) HATPase_c PF02518.26 ORX63448.1 - 3e-31 108.2 0.1 9.8e-31 106.6 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4279 PF14106.6 ORX63448.1 - 1.7e-27 95.9 0.0 38 4.5 0.0 26.8 30 2 2 32 32 28 0 Domain of unknown function (DUF4279) Syntaxin_2 PF14523.6 ORX63448.1 - 7.7e-26 90.4 93.6 2 8.8 0.1 33.1 19 9 10 33 33 33 3 Syntaxin-like protein DUF5082 PF16888.5 ORX63448.1 - 9e-19 68.0 55.9 0.13 12.5 0.1 23.1 10 8 15 27 27 26 4 Domain of unknown function (DUF5082) Apolipoprotein PF01442.18 ORX63448.1 - 2.6e-18 66.6 32.8 0.44 10.4 0.3 18.5 7 6 4 13 13 13 4 Apolipoprotein A1/A4/E domain PhoR PF11808.8 ORX63448.1 - 4e-18 65.6 0.0 59 4.2 0.1 19.9 23 0 0 23 23 19 0 Phosphate regulon sensor protein PhoR WXG100 PF06013.12 ORX63448.1 - 3.3e-16 59.3 105.0 3.4 8.0 0.1 37.6 33 9 11 44 44 42 1 Proteins of 100 residues with WXG HisKA PF00512.25 ORX63448.1 - 3.6e-16 58.9 2.2 8.5e-15 54.6 0.5 4.9 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain DUF4795 PF16043.5 ORX63448.1 - 2.7e-13 50.0 89.1 4.3 6.9 0.5 24.6 3 3 16 20 20 20 1 Domain of unknown function (DUF4795) Response_reg PF00072.24 ORX63448.1 - 1.7e-10 41.1 0.1 5.8e-08 32.9 0.0 3.7 3 0 0 3 3 3 1 Response regulator receiver domain GLE1 PF07817.13 ORX63448.1 - 2e-10 40.3 40.6 0.86 8.8 0.1 20.5 19 6 7 27 27 25 1 GLE1-like protein Phage_Mu_Gam PF07352.12 ORX63448.1 - 1.3e-09 38.1 0.1 30 4.5 0.0 13.3 20 0 0 20 20 11 0 Bacteriophage Mu Gam like protein UDPG_MGDP_dh PF00984.19 ORX63448.1 - 1.7e-09 37.7 31.5 1.4e+02 2.7 0.0 23.9 29 0 0 29 29 24 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain DUF2397 PF09660.10 ORX63448.1 - 3.4e-08 32.8 3.5 11 4.8 0.0 11.5 10 4 5 16 16 16 0 Protein of unknown function (DUF2397) Rab5-bind PF09311.11 ORX63448.1 - 4.1e-08 33.0 100.8 2.2 7.6 0.0 27.8 15 8 13 32 32 31 2 Rabaptin-like protein TMF_TATA_bd PF12325.8 ORX63448.1 - 9.4e-08 32.3 10.7 25 5.1 0.2 16.9 25 1 1 26 26 16 0 TATA element modulatory factor 1 TATA binding HTH_6 PF01418.17 ORX63448.1 - 5.9e-07 29.4 22.6 7.4 6.6 0.0 18.4 21 0 0 21 21 16 0 Helix-turn-helix domain, rpiR family SpoIIID PF12116.8 ORX63448.1 - 1.2e-06 28.5 92.2 7.6 6.7 0.1 28.0 33 0 0 33 33 28 0 Stage III sporulation protein D DUF3829 PF12889.7 ORX63448.1 - 3.7e-06 26.6 96.3 2.7 7.4 0.0 23.4 17 9 8 27 27 27 2 Protein of unknown function (DUF3829) CENP-F_leu_zip PF10473.9 ORX63448.1 - 5.2e-06 26.5 75.2 2.9 7.9 0.0 28.6 33 2 1 35 35 34 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 ORX63448.1 - 7.6e-06 24.9 78.8 0.25 10.0 0.2 15.4 5 4 13 19 19 19 5 AAA domain MAD PF05557.13 ORX63448.1 - 0.00019 19.9 0.1 0.36 9.2 0.0 4.3 3 0 0 3 3 3 1 Mitotic checkpoint protein DUF1471 PF07338.13 ORX63448.1 - 0.0005 20.0 2.1 2.7 8.0 0.0 8.9 11 0 0 11 11 3 1 Protein of unknown function (DUF1471) UvrA_inter PF17760.1 ORX63448.1 - 0.00072 19.6 14.1 13 5.9 0.1 13.9 20 0 0 20 20 11 0 UvrA interaction domain Prominin PF05478.11 ORX63448.1 - 0.0016 16.5 118.1 0.12 10.3 0.4 21.1 8 6 12 24 24 24 9 Prominin SURF2 PF05477.11 ORX63448.1 - 0.041 13.6 3.3 0.085 12.5 3.3 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF1759 PF03564.15 ORX63448.1 - 0.22 11.5 27.9 64 3.4 0.1 14.8 19 1 1 20 20 12 0 Protein of unknown function (DUF1759) TPR_MLP1_2 PF07926.12 ORX63448.1 - 0.28 11.2 3.0 23 5.1 0.0 6.1 4 0 0 4 4 3 0 TPR/MLP1/MLP2-like protein Methyltransf_8 PF05148.15 ORX63448.1 - 0.62 9.9 33.9 4 7.2 0.0 13.6 15 4 3 19 19 15 0 Hypothetical methyltransferase Spc7 PF08317.11 ORX63448.1 - 0.64 8.8 11.6 42 2.9 0.1 7.2 6 1 0 6 6 6 0 Spc7 kinetochore protein Dynactin_p22 PF07426.11 ORX63448.1 - 0.77 9.6 15.0 34 4.3 0.0 10.5 9 0 0 9 9 7 0 Dynactin subunit p22 HIP1_clath_bdg PF16515.5 ORX63448.1 - 0.91 10.2 10.2 29 5.3 0.0 8.7 7 0 0 7 7 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SMC_Nse1 PF07574.13 ORX63448.1 - 0.97 9.3 36.9 5.3 6.9 0.0 14.5 14 6 7 21 21 16 0 Nse1 non-SMC component of SMC5-6 complex UPF0449 PF15136.6 ORX63448.1 - 3.7 8.1 10.0 67 4.0 0.1 8.6 10 0 0 10 10 3 0 Uncharacterised protein family UPF0449 TMPIT PF07851.13 ORX63448.1 - 3.8 6.7 7.0 25 4.0 0.0 5.8 5 1 1 6 6 6 0 TMPIT-like protein MbeD_MobD PF04899.12 ORX63448.1 - 8.1 6.6 8.5 1.2e+02 2.8 0.1 8.3 5 0 0 5 5 1 0 MbeD/MobD like DnaJ PF00226.31 ORX63458.1 - 1.1e-15 57.5 1.3 2.2e-15 56.5 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain IQ PF00612.27 ORX63459.1 - 8.4e-07 28.2 9.8 0.0029 17.2 1.2 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif RabGAP-TBC PF00566.18 ORX63460.1 - 3.9e-32 111.6 0.0 5.3e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MliC PF09864.9 ORX63464.1 - 0.12 12.4 0.2 0.22 11.5 0.2 1.5 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme IF-2B PF01008.17 ORX63468.1 - 1.2e-06 28.0 0.1 1.2e-06 28.0 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF4396 PF14342.6 ORX63468.1 - 0.057 13.8 0.0 0.059 13.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) Sulfatase PF00884.23 ORX63469.1 - 2.5e-09 37.0 0.2 5.5e-09 35.9 0.1 1.4 1 1 1 2 2 2 1 Sulfatase SpoIIE PF07228.12 ORX63478.1 - 4.8e-06 26.6 0.0 0.00066 19.7 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ORX63478.1 - 0.00016 21.4 0.0 0.13 11.8 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ORX63478.1 - 0.0045 16.7 0.2 0.099 12.3 0.2 2.4 1 1 0 1 1 1 1 Protein phosphatase 2C Zn_clus PF00172.18 ORX63486.1 - 7.8e-13 48.3 11.5 9.2e-13 48.1 11.5 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 ORX63486.1 - 0.091 13.1 4.7 0.44 10.9 1.3 2.1 2 0 0 2 2 2 0 Opy2 protein ISG65-75 PF11727.8 ORX63486.1 - 0.44 9.7 4.8 0.48 9.6 4.8 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Fungal_trans PF04082.18 ORX63487.1 - 2.5e-12 46.4 0.0 2.5e-12 46.4 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4695 PF15766.5 ORX63494.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) ABC_tran PF00005.27 ORX63504.1 - 4.4e-25 88.8 0.0 6.4e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 ORX63504.1 - 0.0021 18.1 0.1 0.003 17.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.17 ORX63504.1 - 0.0055 16.8 0.1 0.0087 16.2 0.1 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain MeaB PF03308.16 ORX63504.1 - 0.0064 15.5 0.1 0.0094 15.0 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 ORX63504.1 - 0.026 14.3 0.1 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX63504.1 - 0.035 13.9 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX63504.1 - 0.041 14.3 0.0 0.063 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 ORX63504.1 - 0.1 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) T2SSE PF00437.20 ORX63504.1 - 0.14 11.2 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_15 PF13175.6 ORX63504.1 - 0.2 11.3 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ORX63504.1 - 0.21 12.1 0.1 0.32 11.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain Phosphodiest PF01663.22 ORX63508.1 - 7.5e-08 32.3 3.6 2.7e-06 27.2 0.5 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase RACo_linker PF17650.1 ORX63508.1 - 0.034 14.0 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 RACo linker region HgmA PF04209.13 ORX63515.1 - 1.1e-63 215.4 1.4 1.2e-63 215.3 1.4 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Trypan_PARP PF05887.11 ORX63516.1 - 0.011 15.7 37.2 0.097 12.7 37.2 1.9 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3306 PF11748.8 ORX63516.1 - 0.94 10.4 6.4 1.1 10.2 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Pre-SET PF05033.16 ORX63521.1 - 0.017 15.8 0.5 0.032 14.9 0.5 1.4 1 0 0 1 1 1 0 Pre-SET motif Fer4_24 PF18109.1 ORX63524.1 - 2.4 8.5 4.9 58 4.1 0.0 3.2 3 0 0 3 3 3 0 Ferredoxin I 4Fe-4S cluster domain Phage_holin_3_7 PF05449.11 ORX63545.1 - 0.88 9.6 3.9 0.34 10.9 0.4 2.0 2 0 0 2 2 2 0 Putative 3TM holin, Phage_holin_3 Bromodomain PF00439.25 ORX63547.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Bromodomain HA2 PF04408.23 ORX63550.1 - 1.5e-07 31.6 0.0 5.2e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 ORX63550.1 - 1.6e-06 28.0 0.0 3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX63550.1 - 1.8e-05 25.0 0.0 7.1e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Trypan_PARP PF05887.11 ORX63550.1 - 0.0002 21.4 13.2 0.00043 20.3 13.2 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) AAA_19 PF13245.6 ORX63550.1 - 0.063 13.6 0.1 0.33 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 ORX63550.1 - 0.19 11.7 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SPESP1 PF15754.5 ORX63550.1 - 1.2 8.2 6.4 0.81 8.8 4.4 1.6 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 AMP-binding_C PF13193.6 ORX63551.1 - 1.7e-15 57.8 0.3 2.3e-15 57.3 0.3 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NIPSNAP PF07978.13 ORX63555.1 - 1.8e-27 95.5 0.2 1.5e-14 54.0 0.0 3.2 2 1 1 3 3 3 3 NIPSNAP Na_Ca_ex PF01699.24 ORX63559.1 - 6.9e-08 32.6 3.5 8.7e-08 32.3 3.5 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein MSSP PF03940.13 ORX63559.1 - 2 8.1 7.2 0.86 9.3 4.8 1.7 1 1 0 1 1 1 0 Male specific sperm protein Metallophos PF00149.28 ORX63560.1 - 1.1e-08 35.9 4.8 1e-07 32.7 4.8 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX63560.1 - 2.2e-05 24.7 1.5 8.9e-05 22.7 1.5 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SNF2_N PF00176.23 ORX63571.1 - 1.9e-41 142.0 0.2 2.1e-41 141.8 0.2 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 ORX63571.1 - 5.4e-06 26.3 0.0 6.4e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ORX63571.1 - 0.16 11.6 0.1 0.34 10.6 0.0 1.6 2 0 0 2 2 2 0 SWI2/SNF2 ATPase HMG_box PF00505.19 ORX63574.1 - 3e-08 34.0 0.0 3.7e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_5 PF14887.6 ORX63574.1 - 8.3e-06 25.7 0.1 9.7e-06 25.5 0.1 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box 5 HMG_box_2 PF09011.10 ORX63574.1 - 0.00037 21.0 0.0 0.0005 20.6 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain Phage_lysozyme PF00959.19 ORX63575.1 - 5e-14 52.7 0.0 7.9e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX63575.1 - 0.00013 22.2 0.1 0.00043 20.5 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain RAP1 PF07218.11 ORX63575.1 - 0.036 12.4 0.1 0.047 12.0 0.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3432 PF11914.8 ORX63577.1 - 0.00033 20.8 0.5 0.8 10.0 0.0 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF3432) DUF1464 PF07318.12 ORX63577.1 - 0.034 13.3 0.3 5.2 6.1 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1464) AMP-binding PF00501.28 ORX63578.1 - 1.2e-76 258.1 0.0 1.5e-76 257.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX63578.1 - 3.2e-19 69.7 0.5 8.3e-19 68.4 0.5 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ORX63578.1 - 6.6e-18 64.4 0.1 1.7e-17 63.1 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus DUF1059 PF06348.11 ORX63578.1 - 0.034 14.4 1.0 0.097 12.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) ArsA_HSP20 PF17886.1 ORX63579.1 - 0.005 16.4 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 ORX63579.1 - 0.0066 16.6 1.9 0.25 11.5 0.0 2.4 2 0 0 2 2 2 1 Hsp20/alpha crystallin family 4HBT_3 PF13622.6 ORX63580.1 - 6.2e-41 141.3 2.9 7.1e-41 141.1 2.9 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX63580.1 - 6.3e-17 61.7 0.0 2.9e-13 49.8 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 ORX63580.1 - 0.0028 18.0 0.5 0.93 9.9 0.2 2.3 2 0 0 2 2 2 2 Thioesterase superfamily VPS9 PF02204.18 ORX63581.1 - 1.6e-33 115.0 0.1 3.6e-33 113.9 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 ORX63581.1 - 1.1e-11 44.8 0.1 3.2e-10 40.1 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF5601) CUE PF02845.16 ORX63581.1 - 8.4e-05 22.2 0.1 0.00017 21.2 0.1 1.5 1 0 0 1 1 1 1 CUE domain NOA36 PF06524.12 ORX63581.1 - 0.48 9.7 1.7 0.92 8.8 1.7 1.4 1 0 0 1 1 1 0 NOA36 protein Fes1 PF08609.10 ORX63582.1 - 2.1e-11 44.5 1.5 6.4e-11 43.0 1.4 1.9 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT PF02985.22 ORX63582.1 - 4.2e-06 26.6 0.7 0.021 15.1 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ORX63582.1 - 8.9e-06 26.0 0.3 5.9e-05 23.4 0.0 2.4 2 1 1 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 ORX63582.1 - 0.0017 18.8 0.2 0.052 14.1 0.1 3.2 2 1 2 4 4 4 2 HEAT-like repeat NNMT_PNMT_TEMT PF01234.17 ORX63582.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF3361 PF11841.8 ORX63582.1 - 0.021 14.8 0.1 1.2 9.1 0.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF3361) Arm PF00514.23 ORX63582.1 - 0.074 13.1 0.0 0.39 10.8 0.0 2.2 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat IDEAL PF08858.10 ORX63582.1 - 8.9 6.1 6.7 3.9 7.3 1.4 2.3 2 0 0 2 2 2 0 IDEAL domain DNA_pol_D_N PF18018.1 ORX63583.1 - 1.4e-05 25.2 0.0 1.6e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DUF1987 PF09345.10 ORX63583.1 - 0.08 12.6 0.0 0.089 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) Glyco_hydro_18 PF00704.28 ORX63589.1 - 3.3e-26 92.8 6.0 1.1e-25 91.1 6.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 TPPK_C PF12555.8 ORX63589.1 - 0.1 12.6 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal AA_permease PF00324.21 ORX63597.1 - 9.1e-103 344.4 38.5 8.1e-89 298.4 29.8 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 ORX63597.1 - 5.7e-24 84.7 39.7 1.7e-23 83.1 39.7 1.7 1 1 0 1 1 1 1 Amino acid permease RRM_1 PF00076.22 ORX63598.1 - 4.9e-28 96.7 0.0 4.3e-15 55.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX63598.1 - 0.002 18.2 0.1 0.12 12.4 0.0 2.4 2 0 0 2 2 2 1 Limkain b1 DbpA PF03880.15 ORX63598.1 - 0.012 15.5 0.1 2 8.4 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Calcipressin PF04847.12 ORX63598.1 - 0.04 13.7 0.1 4.2 7.1 0.0 2.5 3 0 0 3 3 3 0 Calcipressin RRM_occluded PF16842.5 ORX63598.1 - 0.049 13.5 0.0 0.55 10.1 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_7 PF16367.5 ORX63598.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif RNA_bind PF08675.11 ORX63598.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain AAA PF00004.29 ORX63602.1 - 1.2e-40 139.0 0.3 3e-40 137.7 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX63602.1 - 6.8e-11 41.8 0.2 1.5e-10 40.7 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ORX63602.1 - 1.2e-05 25.8 0.2 0.0096 16.3 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX63602.1 - 1.3e-05 25.3 0.0 5.3e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX63602.1 - 0.00012 21.9 0.0 0.00038 20.2 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX63602.1 - 0.00035 20.7 0.0 0.002 18.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX63602.1 - 0.0004 20.7 0.4 0.051 13.9 0.0 2.5 1 1 0 2 2 2 1 AAA domain Prot_ATP_ID_OB PF16450.5 ORX63602.1 - 0.00055 19.8 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_33 PF13671.6 ORX63602.1 - 0.0026 17.9 0.0 0.0088 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ORX63602.1 - 0.0027 17.2 0.2 0.025 14.1 0.1 2.1 2 0 0 2 2 2 1 PhoH-like protein Zeta_toxin PF06414.12 ORX63602.1 - 0.0032 16.8 1.2 0.29 10.4 0.1 2.3 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 ORX63602.1 - 0.0035 16.7 0.0 0.0099 15.3 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ORX63602.1 - 0.0068 15.6 0.0 0.017 14.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Methyltrans_Mon PF14314.6 ORX63602.1 - 0.0083 14.2 0.3 0.012 13.7 0.3 1.1 1 0 0 1 1 1 1 Virus-capping methyltransferase IstB_IS21 PF01695.17 ORX63602.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 ORX63602.1 - 0.029 14.7 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX63602.1 - 0.054 13.0 0.1 0.13 11.8 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ORX63602.1 - 0.055 13.8 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 ORX63602.1 - 0.056 13.1 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 ORX63602.1 - 0.057 13.1 0.1 0.19 11.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX63602.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ORX63602.1 - 0.43 10.3 0.0 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF4023 PF13215.6 ORX63602.1 - 1.3 9.1 4.1 9.1 6.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) MitMem_reg PF13012.6 ORX63603.1 - 2.3e-05 24.7 1.3 0.0017 18.7 0.2 1.9 1 1 1 2 2 2 2 Maintenance of mitochondrial structure and function Glutaredoxin2_C PF04399.13 ORX63603.1 - 0.013 15.3 0.2 0.015 15.2 0.2 1.1 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain BLOC1_2 PF10046.9 ORX63603.1 - 0.019 15.3 0.3 0.024 14.9 0.3 1.3 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Transferase PF02458.15 ORX63612.1 - 3.9e-19 68.6 0.0 2.4e-18 66.0 0.0 1.8 1 1 0 1 1 1 1 Transferase family LRR_2 PF07723.13 ORX63612.1 - 0.18 12.5 0.0 0.5 11.1 0.0 1.8 1 0 0 1 1 1 0 Leucine Rich Repeat MAP65_ASE1 PF03999.12 ORX63618.1 - 7.4 5.1 8.2 8.4 5.0 8.2 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TERB2 PF15101.6 ORX63619.1 - 2.1 8.4 7.1 4.3 7.3 7.1 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 ODAPH PF15848.5 ORX63623.1 - 4.2 7.9 7.7 1.3 9.5 3.1 2.4 2 1 1 3 3 3 0 Odontogenesis associated phosphoprotein CBP4 PF07960.11 ORX63626.1 - 0.012 15.5 0.2 0.1 12.4 0.0 2.1 1 1 1 2 2 2 0 CBP4 Cation_ATPase_C PF00689.21 ORX63632.1 - 0.056 13.2 0.5 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus bZIP_1 PF00170.21 ORX63634.1 - 2.7e-10 40.2 9.9 3.7e-10 39.8 9.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX63634.1 - 2.5e-07 30.7 12.6 4.2e-07 30.0 12.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX63634.1 - 0.00049 20.6 6.8 0.0007 20.1 6.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Aft1_HRA PF11786.8 ORX63635.1 - 1.9e-08 34.5 6.5 5.7e-08 33.0 6.5 1.9 1 1 0 1 1 1 1 Aft1 HRA domain Aft1_OSA PF11785.8 ORX63635.1 - 1.3e-05 25.5 1.2 2.1e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain Glyco_transf_15 PF01793.16 ORX63638.1 - 3.9e-84 282.7 0.5 2.9e-42 145.1 0.0 2.0 1 1 1 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase DNA_topoisoIV PF00521.20 ORX63638.1 - 0.17 10.7 0.0 0.3 9.9 0.0 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A E1-E2_ATPase PF00122.20 ORX63639.1 - 4.6e-24 84.9 0.0 1.2e-23 83.6 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX63639.1 - 1.5e-09 38.5 0.3 0.00042 20.7 0.4 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX63639.1 - 0.00015 21.3 0.1 0.00094 18.8 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus LapD_MoxY_N PF16448.5 ORX63648.1 - 0.085 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain Pkinase PF00069.25 ORX63649.1 - 5.8e-07 29.2 0.0 7.2e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ORX63650.1 - 2.5e-21 76.2 0.0 2.7e-21 76.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63650.1 - 1.4e-12 47.4 0.0 1.5e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX63650.1 - 0.017 14.5 0.0 0.018 14.4 0.0 1.0 1 0 0 1 1 1 0 Kinase-like TMEM237 PF15383.6 ORX63656.1 - 0.02 14.0 0.1 0.02 14.0 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 237 OrfB_IS605 PF01385.19 ORX63656.1 - 0.03 14.5 0.2 0.035 14.3 0.2 1.1 1 0 0 1 1 1 0 Probable transposase PBD PF00786.28 ORX63657.1 - 3.6e-14 52.8 0.0 6.5e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain PA PF02225.22 ORX63661.1 - 9.3e-08 32.0 0.6 2e-07 30.9 0.6 1.6 1 0 0 1 1 1 1 PA domain Peptidase_S8 PF00082.22 ORX63661.1 - 0.0027 17.0 0.4 0.0033 16.7 0.4 1.1 1 0 0 1 1 1 1 Subtilase family Epimerase PF01370.21 ORX63669.1 - 2.9e-37 128.4 0.0 3.4e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX63669.1 - 1.1e-33 117.0 0.1 1.9e-23 83.4 0.0 2.0 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ORX63669.1 - 8e-14 51.5 0.1 1.5e-09 37.4 0.0 2.8 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX63669.1 - 1.3e-11 44.2 0.0 1.6e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ORX63669.1 - 2.1e-11 43.4 0.1 2e-09 36.9 0.1 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ORX63669.1 - 1.1e-08 34.6 0.0 0.00057 19.1 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ORX63669.1 - 0.00032 20.7 0.0 0.0051 16.7 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 ORX63669.1 - 0.00039 19.9 0.1 0.00068 19.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX63669.1 - 0.0019 18.2 0.3 0.034 14.1 0.1 2.0 1 1 1 2 2 2 1 KR domain NmrA PF05368.13 ORX63669.1 - 0.025 14.1 0.0 0.046 13.3 0.0 1.4 1 1 0 1 1 1 0 NmrA-like family 7tm_3 PF00003.22 ORX63677.1 - 0.00036 20.3 28.0 0.00049 19.9 28.0 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR PgaD PF13994.6 ORX63678.1 - 0.97 9.5 9.0 0.16 12.0 3.6 2.3 1 1 1 2 2 2 0 PgaD-like protein DUF202 PF02656.15 ORX63682.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF202) AMP-binding PF00501.28 ORX63683.1 - 9.3e-19 67.3 0.0 8.7e-18 64.1 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme ACAS_N PF16177.5 ORX63683.1 - 3.5e-10 39.6 0.8 7e-10 38.7 0.8 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ORX63683.1 - 0.0012 19.7 0.4 0.003 18.5 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RNA_pol_L_2 PF13656.6 ORX63686.1 - 5.7e-11 42.0 4.1 2.6 7.9 0.0 8.2 5 3 3 8 8 8 3 RNA polymerase Rpb3/Rpb11 dimerisation domain Myb_DNA-bind_2 PF08914.11 ORX63686.1 - 1.3e-06 28.5 18.3 0.4 10.9 0.0 7.2 4 3 5 9 9 9 2 Rap1 Myb domain Ribosomal_S3_C PF00189.20 ORX63686.1 - 3.1e-06 27.6 0.2 20 5.8 0.0 5.8 6 0 0 6 6 6 0 Ribosomal protein S3, C-terminal domain Y2_Tnp PF04986.13 ORX63686.1 - 5.9e-05 23.2 7.1 1.2 9.2 0.1 5.0 1 1 3 5 5 5 2 Putative transposase ssDNA_TraI_N PF18272.1 ORX63686.1 - 0.00031 20.7 0.3 97 3.1 0.0 7.4 5 3 5 10 10 10 0 single-stranded DNA binding TraI N-terminal subdomain DUF3938 PF13074.6 ORX63686.1 - 0.00047 20.3 1.4 18 5.6 0.0 5.4 3 3 1 5 5 5 0 Protein of unknown function (DUF3938) DUF5554 PF17709.1 ORX63686.1 - 0.0023 18.0 5.1 34 4.6 0.1 5.7 2 2 3 6 6 6 0 Family of unknown function (DUF5554) DnaB PF00772.21 ORX63686.1 - 0.0053 16.8 14.7 28 4.9 0.1 7.9 6 4 2 8 8 8 0 DnaB-like helicase N terminal domain DUF960 PF06124.11 ORX63686.1 - 0.0082 16.8 0.4 13 6.5 0.0 4.6 2 2 4 6 6 6 0 Staphylococcal protein of unknown function (DUF960) RNA_pol_L PF01193.24 ORX63686.1 - 0.014 14.8 0.0 61 3.2 0.0 4.5 5 0 0 5 5 5 0 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF4944 PF16302.5 ORX63686.1 - 0.02 14.9 1.9 0.06 13.4 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4944) Toprim_N PF08275.11 ORX63686.1 - 0.033 14.2 0.3 4 7.5 0.1 2.8 2 1 1 3 3 3 0 DNA primase catalytic core, N-terminal domain WHAMM-JMY_N PF15920.5 ORX63686.1 - 0.043 13.7 0.0 83 3.2 0.0 5.5 6 2 3 9 9 9 0 N-terminal of Junction-mediating and WASP homolog-associated DUF3318 PF11780.8 ORX63686.1 - 0.13 12.3 0.1 83 3.1 0.0 3.8 4 1 1 5 5 5 0 Protein of unknown function (DUF3318) ESR1_C PF12743.7 ORX63686.1 - 0.68 9.8 3.0 49 3.8 0.0 3.9 4 0 0 4 4 4 0 Oestrogen-type nuclear receptor final C-terminal ArfGap PF01412.18 ORX63687.1 - 2.4e-34 117.9 0.2 5.5e-34 116.7 0.2 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4695 PF15766.5 ORX63690.1 - 0.034 14.4 0.0 0.076 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) Prefoldin PF02996.17 ORX63691.1 - 4.2e-15 55.7 0.0 1e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 Prefoldin subunit DUF4246 PF14033.6 ORX63701.1 - 1.3e-30 107.0 0.0 1.5e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) RRM_1 PF00076.22 ORX63709.1 - 1.2e-18 66.7 0.0 3.1e-14 52.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX63709.1 - 0.0014 18.4 0.0 0.0043 16.9 0.0 1.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nab6_mRNP_bdg PF10567.9 ORX63709.1 - 0.013 15.0 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 RNA-recognition motif RRM_5 PF13893.6 ORX63709.1 - 0.033 13.8 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin_4 PF13462.6 ORX63711.1 - 3.6e-09 37.0 0.0 4.8e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ORX63711.1 - 8.8e-05 22.4 0.5 0.012 15.4 0.1 2.3 1 1 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 ORX63711.1 - 0.1 13.1 0.0 0.9 10.0 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain WPP PF13943.6 ORX63717.1 - 0.073 13.5 0.0 0.073 13.5 0.0 1.1 1 0 0 1 1 1 0 WPP domain HTH_39 PF14090.6 ORX63717.1 - 0.1 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain HIT PF01230.23 ORX63725.1 - 1.3e-21 77.2 0.3 1.6e-21 76.8 0.3 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX63725.1 - 8.7e-06 26.2 0.3 1.8e-05 25.2 0.3 1.4 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX63725.1 - 0.011 15.6 0.5 0.017 15.0 0.5 1.4 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 zf-Tim10_DDP PF02953.15 ORX63727.1 - 7.4 6.3 9.0 23 4.8 0.5 3.4 3 1 1 4 4 4 0 Tim10/DDP family zinc finger F-box-like PF12937.7 ORX63734.1 - 0.11 12.3 0.1 0.75 9.7 0.0 2.4 3 0 0 3 3 3 0 F-box-like zf-C2H2 PF00096.26 ORX63735.1 - 6.3e-25 86.2 26.6 2.1e-06 27.9 2.3 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX63735.1 - 9.4e-22 76.4 22.0 3.2e-08 33.6 0.1 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX63735.1 - 3.7e-16 58.4 24.9 0.00041 21.0 1.7 4.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 ORX63735.1 - 9.6e-08 32.2 10.3 0.28 11.6 0.3 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 ORX63735.1 - 1.6e-07 30.9 11.1 0.023 14.5 0.3 4.5 4 0 0 4 4 4 3 C2H2-type zinc-finger domain FOXP-CC PF16159.5 ORX63735.1 - 1.7e-07 31.8 11.2 0.08 13.6 0.2 4.0 1 1 3 4 4 4 3 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX63735.1 - 5.9e-07 29.6 12.3 0.17 12.2 0.1 4.3 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 ORX63735.1 - 0.00014 21.7 7.5 0.015 15.2 0.4 3.8 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 ORX63735.1 - 0.0013 19.0 8.1 0.17 12.2 0.4 2.8 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX63735.1 - 0.021 14.6 17.2 0.18 11.6 1.6 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX63735.1 - 0.026 14.5 0.3 0.026 14.5 0.3 3.8 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX63735.1 - 0.031 14.4 5.0 3.7 7.7 0.1 3.4 1 1 2 4 4 4 0 Aberrant zinc-finger zf-TRAF PF02176.18 ORX63735.1 - 0.18 12.5 11.5 0.26 12.0 1.3 3.0 1 1 1 3 3 3 0 TRAF-type zinc finger zf-C2H2_2 PF12756.7 ORX63735.1 - 0.91 9.9 6.8 14 6.0 0.3 2.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 ORX63735.1 - 9 6.3 9.8 6.1 6.8 0.1 3.9 4 1 0 4 4 4 0 LYAR-type C2HC zinc finger baeRF_family2 PF18844.1 ORX63736.1 - 0.0019 18.3 4.0 0.0019 18.3 4.0 1.5 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 2 DUF1764 PF08576.10 ORX63736.1 - 7.6 7.5 7.9 13 6.8 7.9 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) LRR_4 PF12799.7 ORX63751.1 - 0.096 13.1 1.3 8.4 7.0 0.2 3.4 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Imm70 PF15601.6 ORX63751.1 - 0.17 11.4 0.0 0.43 10.1 0.0 1.6 2 0 0 2 2 2 0 Immunity protein 70 Glyco_hydro_20 PF00728.22 ORX63753.1 - 6.5e-72 242.8 0.1 9.4e-72 242.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX63753.1 - 4e-17 63.1 0.1 9.8e-17 61.9 0.0 1.7 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX63753.1 - 0.002 18.9 0.0 0.0034 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Cellulase PF00150.18 ORX63753.1 - 0.034 13.6 0.2 0.053 13.0 0.2 1.2 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Evr1_Alr PF04777.13 ORX63753.1 - 0.048 14.1 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Erv1 / Alr family MOZ_SAS PF01853.18 ORX63755.1 - 1.5e-78 262.6 0.2 2.8e-78 261.7 0.2 1.5 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX63755.1 - 3.8e-22 77.6 6.3 1e-21 76.2 6.3 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 ORX63755.1 - 2.9e-19 68.7 0.1 6.7e-19 67.5 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 ORX63755.1 - 0.00024 21.4 0.0 0.00052 20.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX63755.1 - 0.0022 18.2 0.0 0.0055 16.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Inhibitor_I9 PF05922.16 ORX63756.1 - 0.026 15.2 0.0 0.086 13.5 0.0 1.6 1 1 1 2 2 2 0 Peptidase inhibitor I9 CTP_transf_like PF01467.26 ORX63766.1 - 1.5e-21 77.1 0.3 7.6e-14 52.1 0.1 2.8 2 1 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 ORX63766.1 - 0.017 15.0 0.3 1.3 8.9 0.2 3.0 2 1 2 4 4 4 0 FAD synthetase p450 PF00067.22 ORX63773.1 - 1.4e-51 175.7 0.0 6.5e-50 170.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 YTV PF07639.11 ORX63778.1 - 8.5e-05 22.5 38.3 0.00041 20.3 13.7 6.3 1 1 6 7 7 7 6 YTV H_kinase_N PF12282.8 ORX63778.1 - 0.69 9.9 8.5 4.1 7.4 1.3 2.3 1 1 1 2 2 2 0 Signal transduction histidine kinase Rib_recp_KP_reg PF05104.12 ORX63778.1 - 8 7.5 32.1 9 7.3 13.0 3.0 1 1 2 3 3 3 0 Ribosome receptor lysine/proline rich region HMG_box PF00505.19 ORX63801.1 - 1.9e-20 73.1 1.3 5.4e-20 71.6 0.1 2.0 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX63801.1 - 1.1e-13 51.6 1.4 1.6e-13 51.1 0.1 1.8 2 0 0 2 2 2 1 HMG-box domain DUF3552 PF12072.8 ORX63801.1 - 0.018 14.4 1.3 0.024 14.0 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) FHA PF00498.26 ORX63802.1 - 1.2e-08 35.1 0.0 1.6e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX63802.1 - 0.022 15.1 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 ORX63802.1 - 0.063 13.5 0.0 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 FHA domain Cwf_Cwc_15 PF04889.12 ORX63811.1 - 0.0071 16.1 18.2 0.0083 15.9 18.2 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Myc_N PF01056.18 ORX63811.1 - 0.081 12.8 4.2 0.089 12.7 4.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 ORX63811.1 - 0.094 12.0 18.4 0.11 11.9 18.4 1.1 1 0 0 1 1 1 0 NOA36 protein Dicty_REP PF05086.12 ORX63811.1 - 0.2 9.6 6.3 0.16 9.9 6.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RNA_pol_3_Rpc31 PF11705.8 ORX63811.1 - 0.2 11.9 15.1 0.23 11.7 15.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RR_TM4-6 PF06459.12 ORX63811.1 - 0.37 10.6 8.3 0.4 10.4 8.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CENP-B_dimeris PF09026.10 ORX63811.1 - 0.58 10.6 20.0 0.86 10.0 20.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PPP4R2 PF09184.11 ORX63811.1 - 0.83 9.2 13.9 0.88 9.1 13.9 1.1 1 0 0 1 1 1 0 PPP4R2 Nucleo_P87 PF07267.11 ORX63811.1 - 1.1 8.1 6.2 1 8.1 6.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.12 ORX63811.1 - 1.1 7.3 15.0 1.2 7.3 15.0 1.0 1 0 0 1 1 1 0 Nop14-like family Retinal PF15449.6 ORX63811.1 - 1.3 6.8 6.4 1.2 6.8 6.4 1.0 1 0 0 1 1 1 0 Retinal protein FAM176 PF14851.6 ORX63811.1 - 3.7 7.2 10.9 6.4 6.4 10.9 1.4 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 ORX63811.1 - 4 7.3 17.2 5.5 6.9 17.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NARP1 PF12569.8 ORX63811.1 - 5.4 5.8 7.7 6.3 5.6 7.7 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 WD40 PF00400.32 ORX63813.1 - 2e-07 31.6 3.3 2.9 8.9 0.0 6.2 5 2 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63813.1 - 0.00011 22.4 0.0 0.0093 16.3 0.0 3.1 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ORX63813.1 - 0.0012 18.7 0.1 3.1 7.8 0.0 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Kinesin PF00225.23 ORX63834.1 - 0.0013 17.7 0.0 0.0029 16.6 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Macoilin PF09726.9 ORX63834.1 - 0.21 10.1 12.0 0.29 9.7 12.0 1.2 1 0 0 1 1 1 0 Macoilin family Spc7 PF08317.11 ORX63834.1 - 1.4 7.7 7.7 2.2 7.1 7.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TilS PF09179.11 ORX63853.1 - 0.045 14.3 4.9 4.1 8.0 0.8 2.6 2 1 0 2 2 2 0 TilS substrate binding domain RsbRD_N PF14361.6 ORX63853.1 - 2.2 9.0 6.4 0.67 10.7 3.1 1.8 2 1 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Ribonuclease_T2 PF00445.18 ORX63855.1 - 3.5e-33 115.4 1.9 4.8e-33 114.9 1.9 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family CCDC24 PF15669.5 ORX63855.1 - 0.22 11.3 0.8 0.34 10.7 0.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Ribonuclease_T2 PF00445.18 ORX63856.1 - 1.6e-33 116.4 1.4 2.2e-33 116.1 1.4 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family HVSL PF09749.9 ORX63857.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein adh_short PF00106.25 ORX63875.1 - 8.1e-40 136.4 1.3 1.2e-21 77.1 0.3 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX63875.1 - 3.9e-25 88.8 3.4 6.1e-13 48.9 0.7 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX63875.1 - 7.3e-11 42.3 0.1 2.1e-08 34.3 0.1 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ORX63875.1 - 0.00024 21.1 1.8 0.00024 21.0 1.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX63875.1 - 0.00044 19.8 0.4 0.0037 16.7 0.4 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ORX63875.1 - 0.019 14.1 0.0 0.031 13.4 0.0 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 ORX63875.1 - 0.035 14.2 0.1 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 ORX63875.1 - 0.044 13.1 0.0 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GFA PF04828.14 ORX63876.1 - 1.7e-07 31.4 1.0 1.7e-07 31.4 1.0 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme CoiA PF06054.11 ORX63876.1 - 0.15 11.2 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 Competence protein CoiA-like family HscB_4_cys PF18256.1 ORX63876.1 - 2.3 8.1 9.6 0.14 12.0 1.3 2.5 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif PX PF00787.24 ORX63877.1 - 5.8e-12 45.6 0.2 1.4e-11 44.4 0.2 1.7 1 0 0 1 1 1 1 PX domain Pkinase PF00069.25 ORX63884.1 - 2.9e-38 131.7 0.0 3.3e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63884.1 - 1.3e-16 60.7 0.0 1.5e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX63884.1 - 0.19 11.0 0.0 2.4 7.4 0.0 2.0 2 0 0 2 2 2 0 Kinase-like Pkinase PF00069.25 ORX63894.1 - 1.5e-65 221.2 0.0 1.7e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63894.1 - 9.8e-40 136.5 0.0 1.2e-39 136.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX63894.1 - 3.4e-05 23.3 0.2 0.0001 21.7 0.2 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX63894.1 - 5.1e-05 22.2 0.0 6.9e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX63894.1 - 0.0022 17.9 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX63894.1 - 0.0034 16.8 0.2 0.0061 15.9 0.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX63894.1 - 0.044 13.4 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX63894.1 - 0.076 11.9 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Ribonuclease_T2 PF00445.18 ORX63895.1 - 4e-31 108.7 3.8 5.8e-31 108.1 3.8 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Lipase_GDSL_2 PF13472.6 ORX63896.1 - 1.1e-05 26.0 2.5 1.7e-05 25.3 2.5 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX63896.1 - 2e-05 24.7 0.2 2.8e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX63897.1 - 3.8e-08 34.0 0.4 6e-08 33.3 0.4 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX63897.1 - 1.4e-07 31.7 0.3 1.9e-07 31.3 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF4479 PF14794.6 ORX63897.1 - 0.095 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) zf-C2H2 PF00096.26 ORX63898.1 - 2.1e-18 65.6 17.1 1.8e-06 28.1 1.4 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX63898.1 - 5.8e-14 51.6 13.9 0.00011 22.8 2.5 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX63898.1 - 1.6e-10 40.9 10.3 0.00074 19.8 2.4 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX63898.1 - 2.6e-08 33.6 9.6 5.5e-05 23.1 0.4 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 ORX63898.1 - 4.4e-06 26.9 6.1 0.0066 16.8 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX63898.1 - 6.9e-06 26.2 10.4 0.00043 20.5 0.3 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX63898.1 - 1.2e-05 24.9 7.2 0.21 11.4 0.6 3.1 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 ORX63898.1 - 0.00044 20.5 5.6 0.0007 19.8 5.5 1.4 1 1 0 1 1 1 1 C2H2-type zinc ribbon Zn_Tnp_IS1595 PF12760.7 ORX63898.1 - 0.011 15.7 7.7 0.011 15.7 7.7 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf_UBZ PF18439.1 ORX63898.1 - 0.012 15.2 6.4 2.3 7.9 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 ORX63898.1 - 0.061 13.6 11.5 0.63 10.3 4.1 3.0 1 1 1 2 2 2 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 ORX63898.1 - 0.071 13.9 3.2 0.15 12.8 3.2 1.6 1 1 0 1 1 1 0 zinc-ribbon family zf-C2H2_2 PF12756.7 ORX63898.1 - 0.098 13.0 8.3 5.6 7.4 0.8 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc-ribbons_6 PF07191.12 ORX63898.1 - 0.11 12.5 7.1 0.79 9.7 3.0 2.6 1 1 0 2 2 2 0 zinc-ribbons Zn_ribbon_recom PF13408.6 ORX63898.1 - 0.18 12.4 2.5 0.19 12.3 0.8 1.8 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 ORX63898.1 - 0.18 12.1 9.1 0.17 12.2 5.5 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.6 ORX63898.1 - 0.2 11.7 7.6 6.2 6.9 0.5 3.0 1 1 2 3 3 3 0 CpXC protein zf_ZIC PF18366.1 ORX63898.1 - 0.2 11.8 4.5 7.9 6.7 0.6 2.5 2 1 0 2 2 2 0 Zic proteins zinc finger domain Zn-ribbon_8 PF09723.10 ORX63898.1 - 0.22 11.7 8.0 3.4 7.9 3.3 2.8 2 1 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.13 ORX63898.1 - 0.28 11.3 6.6 0.65 10.1 2.1 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 ORX63898.1 - 0.31 11.2 16.5 0.14 12.4 2.3 3.3 2 2 1 3 3 3 0 AN1-like Zinc finger HypA PF01155.19 ORX63898.1 - 0.55 10.3 3.6 1.2 9.2 0.5 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 ORX63898.1 - 5.6 7.0 10.3 40 4.2 6.6 3.0 2 1 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 ORX63898.1 - 8.5 6.4 12.3 0.95 9.4 6.3 2.2 2 1 0 2 2 2 0 SprT-like zinc ribbon domain OrfB_Zn_ribbon PF07282.11 ORX63898.1 - 9.1 6.3 10.3 6.9 6.7 0.3 3.0 2 1 1 3 3 3 0 Putative transposase DNA-binding domain RNA_pol_A_bac PF01000.26 ORX63899.1 - 8.7e-35 119.5 0.2 1.9e-34 118.4 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ORX63899.1 - 8.5e-20 70.0 0.0 1.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SRF-TF PF00319.18 ORX63900.1 - 1.2e-21 75.9 0.1 1.3e-21 75.8 0.1 1.1 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF2721 PF11026.8 ORX63900.1 - 0.052 13.4 0.1 0.058 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) RCDG1 PF15725.5 ORX63901.1 - 0.13 12.7 4.0 0.089 13.2 1.9 1.8 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein CBFD_NFYB_HMF PF00808.23 ORX63906.1 - 5.1e-12 45.9 0.2 9.9e-12 45.0 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX63906.1 - 2.5e-05 24.6 0.2 2.5e-05 24.6 0.2 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX63906.1 - 0.00053 20.1 1.1 0.047 13.8 0.0 2.0 1 1 1 2 2 2 2 Centromere kinetochore component CENP-T histone fold Vfa1 PF08432.10 ORX63906.1 - 0.064 13.6 5.7 0.076 13.3 5.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 ORX63906.1 - 0.094 11.7 1.6 0.11 11.5 1.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 ORX63906.1 - 2.5 6.1 11.0 3.2 5.7 11.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ORX63906.1 - 3 6.0 8.1 3.4 5.8 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein ABC_tran PF00005.27 ORX63907.1 - 2.7e-21 76.5 0.0 4.7e-16 59.6 0.0 4.8 2 2 3 5 5 5 2 ABC transporter ABC_membrane PF00664.23 ORX63907.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region LPMO_10 PF03067.15 ORX63927.1 - 8e-17 62.5 0.5 1.4e-07 32.4 0.1 2.2 2 0 0 2 2 2 2 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX63927.1 - 1.2e-09 38.4 5.5 0.0036 17.3 0.3 3.8 1 1 3 4 4 4 3 Glycosyl hydrolase family 61 GPI-anchored PF10342.9 ORX63927.1 - 2.2e-06 28.4 1.2 0.046 14.5 0.1 2.9 2 0 0 2 2 2 2 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family BNR PF02012.20 ORX63927.1 - 0.024 14.6 0.2 22 5.6 0.0 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat SR-25 PF10500.9 ORX63927.1 - 0.11 12.1 11.3 0.51 9.9 6.4 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 ORX63927.1 - 0.98 10.3 8.7 0.19 12.6 2.4 2.6 2 0 0 2 2 2 0 Chorion family 2 IMUP PF15761.5 ORX63927.1 - 5.1 7.8 14.5 0.48 11.1 5.8 2.9 2 0 0 2 2 2 0 Immortalisation up-regulated protein LPMO_10 PF03067.15 ORX63928.1 - 0.00023 21.9 0.1 0.00038 21.2 0.1 1.4 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading adh_short PF00106.25 ORX63934.1 - 2.4e-36 125.0 8.0 1.8e-34 118.9 1.5 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX63934.1 - 4.8e-31 108.1 1.1 4.8e-31 108.1 1.1 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ORX63934.1 - 1.8e-14 53.4 0.2 2.5e-07 30.3 0.0 3.3 3 0 0 3 3 3 2 MaoC like domain KR PF08659.10 ORX63934.1 - 5e-13 49.3 3.5 1.5e-08 34.8 0.1 2.4 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 ORX63934.1 - 0.0012 19.0 0.0 0.02 15.0 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase PglL_A PF15864.5 ORX63934.1 - 0.72 9.6 6.6 7.4 6.4 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase HSF_DNA-bind PF00447.17 ORX63935.1 - 2.5e-20 72.9 0.4 4.2e-20 72.2 0.4 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding Inv-AAD PF18785.1 ORX63937.1 - 1.1e-13 51.2 1.6 5e-13 49.0 1.6 2.0 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 ORX63937.1 - 2.3e-08 33.9 3.4 1.1e-06 28.4 3.4 2.1 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX63937.1 - 0.0086 15.8 1.7 0.17 11.6 0.6 2.2 2 1 0 2 2 2 1 MafB19-like deaminase ELYS-bb PF16687.5 ORX63937.1 - 0.014 14.0 0.0 0.016 13.8 0.0 1.1 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin Tfb2_C PF18307.1 ORX63957.1 - 0.052 14.0 0.0 0.069 13.6 0.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 (p52) C-terminal domain DUF3888 PF13027.6 ORX63957.1 - 0.1 13.1 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) ABC_tran PF00005.27 ORX63958.1 - 2.5e-31 109.0 8.5 1.9e-15 57.6 0.3 5.1 3 2 1 4 4 3 3 ABC transporter SMC_N PF02463.19 ORX63958.1 - 2.3e-13 50.1 4.1 0.00011 21.7 0.0 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX63958.1 - 9.5e-12 45.3 12.8 0.00051 20.0 0.0 4.8 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 ORX63958.1 - 2.1e-07 30.8 2.8 2.1e-07 30.8 2.8 2.0 2 0 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.23 ORX63958.1 - 3.2e-05 24.0 0.0 0.0053 16.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX63958.1 - 3.3e-05 23.5 0.2 0.021 14.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX63958.1 - 4.5e-05 23.4 0.4 0.027 14.4 0.0 2.7 3 0 0 3 3 2 1 RsgA GTPase AAA_28 PF13521.6 ORX63958.1 - 0.00079 19.7 1.6 0.098 12.9 0.0 3.5 4 0 0 4 4 3 1 AAA domain DUF503 PF04456.12 ORX63958.1 - 0.0048 16.7 0.5 1 9.3 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF503) NB-ARC PF00931.22 ORX63958.1 - 0.005 16.0 0.0 0.91 8.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain IstB_IS21 PF01695.17 ORX63958.1 - 0.0087 15.8 0.1 1.2 8.8 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA PF00004.29 ORX63958.1 - 0.01 16.3 0.9 2.8 8.4 0.1 4.1 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ORX63958.1 - 0.015 15.8 0.2 5.8 7.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 ORX63958.1 - 0.019 14.6 0.1 0.11 12.1 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ORX63958.1 - 0.02 14.6 2.2 0.16 11.7 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain Bac_DnaA PF00308.18 ORX63958.1 - 0.031 14.1 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_23 PF13476.6 ORX63958.1 - 0.044 14.3 11.7 3.2 8.2 8.3 3.2 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX63958.1 - 0.059 13.8 0.0 3.9 7.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 ORX63958.1 - 0.07 12.9 1.5 1 9.0 0.0 3.2 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 ORX63958.1 - 0.075 13.0 0.1 14 5.6 0.0 2.9 3 0 0 3 3 2 0 NACHT domain Dynamin_N PF00350.23 ORX63958.1 - 0.078 13.0 1.3 0.16 12.0 0.0 2.2 2 1 1 3 3 3 0 Dynamin family AAA_22 PF13401.6 ORX63958.1 - 0.11 12.8 3.8 2.9 8.2 0.0 3.7 3 1 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 ORX63958.1 - 0.11 12.7 0.0 3.3 8.0 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 ORX63958.1 - 0.11 12.8 4.6 16 5.8 1.6 3.5 3 1 0 3 3 3 0 AAA ATPase domain DUF1367 PF07105.11 ORX63958.1 - 0.15 11.8 2.6 3.1 7.4 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1367) Prefoldin PF02996.17 ORX63958.1 - 0.17 11.8 1.6 2.2 8.2 0.1 2.7 2 0 0 2 2 2 0 Prefoldin subunit AAA_33 PF13671.6 ORX63958.1 - 0.46 10.7 5.6 22 5.2 0.0 3.8 3 1 0 3 3 3 0 AAA domain FeoB_N PF02421.18 ORX63958.1 - 0.5 9.9 3.1 18 4.8 0.1 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B DUF87 PF01935.17 ORX63958.1 - 9.8 6.2 8.1 14 5.7 0.1 3.4 4 0 0 4 4 3 0 Helicase HerA, central domain Ecl1 PF12855.7 ORX63969.1 - 1.6e-11 45.7 8.1 1.9e-11 45.4 8.1 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2116 PF09889.9 ORX63969.1 - 0.011 15.6 0.9 0.017 15.1 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MRVI1 PF05781.12 ORX63969.1 - 0.17 10.5 0.2 0.18 10.4 0.2 1.0 1 0 0 1 1 1 0 MRVI1 protein CCDC84 PF14968.6 ORX63969.1 - 0.27 10.8 1.3 0.37 10.4 1.3 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 CopK PF11525.8 ORX63970.1 - 0.0018 17.8 0.3 12 5.6 0.0 3.9 4 0 0 4 4 4 1 Copper resistance protein K Peptidase_C70 PF12385.8 ORX63970.1 - 0.014 15.4 0.2 96 2.9 0.0 4.2 4 0 0 4 4 4 0 Papain-like cysteine protease AvrRpt2 CRM1_repeat PF18777.1 ORX63970.1 - 0.056 13.0 1.7 0.47 10.0 0.6 2.6 2 0 0 2 2 2 0 Chromosome region maintenance or exportin repeat YoaP PF14268.6 ORX63970.1 - 0.062 12.8 1.0 5.6 6.6 0.1 2.5 2 0 0 2 2 2 0 YoaP-like ChW PF07538.11 ORX63970.1 - 0.14 12.1 0.8 1.3e+02 2.6 0.0 3.8 3 0 0 3 3 3 0 Clostridial hydrophobic W DUF1180 PF06679.12 ORX63970.1 - 0.77 10.1 5.5 2 8.8 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Ecl1 PF12855.7 ORX63971.1 - 1.6e-11 45.7 8.1 1.9e-11 45.4 8.1 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2116 PF09889.9 ORX63971.1 - 0.011 15.6 0.9 0.017 15.1 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MRVI1 PF05781.12 ORX63971.1 - 0.17 10.5 0.2 0.18 10.4 0.2 1.0 1 0 0 1 1 1 0 MRVI1 protein CCDC84 PF14968.6 ORX63971.1 - 0.27 10.8 1.3 0.37 10.4 1.3 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 MFS_1 PF07690.16 ORX63975.1 - 4.5e-24 85.0 55.4 2.4e-19 69.5 25.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 ORX63976.1 - 4e-25 88.6 0.0 5.2e-23 81.7 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Fas_alpha_ACP PF18325.1 ORX63977.1 - 5.5e-60 202.4 0.0 9.6e-60 201.6 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX63977.1 - 5.2e-52 177.3 0.0 2.9e-49 168.3 0.0 3.6 2 1 1 3 3 3 1 Acyl transferase domain FAS_I_H PF18314.1 ORX63977.1 - 3e-38 131.5 0.0 7.4e-38 130.2 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ORX63977.1 - 1.1e-26 93.9 2.4 6.3e-26 91.5 0.9 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ORX63977.1 - 2.4e-18 65.8 0.0 1.8e-17 63.0 0.0 2.3 1 1 0 1 1 1 1 MaoC like domain Ketoacyl-synt_C PF02801.22 ORX63977.1 - 3.1e-12 46.5 0.0 9e-12 45.1 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain FAS_meander PF17951.1 ORX63977.1 - 8e-10 38.7 0.0 1.6e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydrat_N PF13452.6 ORX63977.1 - 0.0018 18.4 0.0 0.0047 17.1 0.0 1.7 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Epimerase PF01370.21 ORX63977.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.10 ORX63977.1 - 0.069 13.1 0.2 0.47 10.4 0.0 2.5 2 0 0 2 2 2 0 KR domain Thiolase_N PF00108.23 ORX63977.1 - 0.07 12.5 0.9 0.31 10.4 0.1 2.1 2 0 0 2 2 2 0 Thiolase, N-terminal domain 2-Hacid_dh_C PF02826.19 ORX63977.1 - 0.095 12.1 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3583 PF12126.8 ORX63977.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) GDP_Man_Dehyd PF16363.5 ORX63977.1 - 0.16 11.4 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Remorin_C PF03763.13 ORX63977.1 - 0.31 10.9 2.8 0.77 9.7 2.8 1.6 1 0 0 1 1 1 0 Remorin, C-terminal region RRM_1 PF00076.22 ORX63987.1 - 9e-16 57.5 0.0 1.3e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX63987.1 - 3.2e-09 37.2 12.0 3.2e-09 37.2 12.0 1.6 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 DUF5102 PF17104.5 ORX63988.1 - 2.9 7.8 4.4 4 7.4 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Ribosomal_S13_N PF08069.12 ORX64006.1 - 6.1e-15 55.0 2.7 2.5e-12 46.6 0.1 2.5 1 1 1 2 2 2 2 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ORX64006.1 - 5.3e-13 49.0 0.2 6.4e-13 48.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 ORX64006.1 - 0.012 15.6 0.1 0.024 14.6 0.1 1.7 2 0 0 2 2 2 0 'Paired box' domain DUF2028 PF09667.10 ORX64007.1 - 0.0077 16.2 2.2 0.011 15.7 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2028) Pkinase_fungal PF17667.1 ORX64008.1 - 2.4e-06 26.6 0.0 0.0041 16.0 0.0 2.0 1 1 0 2 2 2 2 Fungal protein kinase Flavodoxin_1 PF00258.25 ORX64014.1 - 8.9e-18 64.9 0.1 2.6e-17 63.4 0.0 1.8 2 1 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 ORX64014.1 - 8.2e-13 48.4 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DUF1729 PF08354.10 ORX64015.1 - 1.7e-80 270.6 0.0 5.9e-62 209.6 0.0 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX64015.1 - 4.3e-48 164.5 0.0 3.6e-47 161.4 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX64015.1 - 1.3e-37 129.6 0.0 2.8e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain MaoC_dehydratas PF01575.19 ORX64015.1 - 3.5e-25 88.0 0.0 8.9e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX64015.1 - 1e-21 77.3 0.1 4.9e-13 49.1 0.0 2.6 1 1 1 2 2 2 2 Fatty acid synthase meander beta sheet domain FAS_I_H PF18314.1 ORX64015.1 - 1.6e-14 54.0 0.1 3e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain SAT PF16073.5 ORX64015.1 - 2e-14 53.9 0.0 7e-14 52.1 0.0 2.0 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 ORX64015.1 - 1.1e-07 32.1 0.0 7.2e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX64015.1 - 0.0009 19.3 0.2 0.002 18.1 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta ketoacyl-synt PF00109.26 ORX64016.1 - 0.002 17.8 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain adh_short PF00106.25 ORX64025.1 - 1.4e-09 37.7 2.8 1.7e-07 30.9 0.3 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX64025.1 - 2.5e-07 30.5 1.2 3.4e-05 23.5 0.1 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase DUF948 PF06103.11 ORX64026.1 - 2.1 8.7 11.8 0.46 10.8 7.1 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) LUC7 PF03194.15 ORX64026.1 - 6.1 6.4 20.2 63 3.1 20.2 2.0 1 1 0 1 1 1 0 LUC7 N_terminus Phage_lysozyme PF00959.19 ORX64030.1 - 5e-14 52.7 0.0 7.9e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX64030.1 - 0.00013 22.2 0.1 0.00043 20.5 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain RAP1 PF07218.11 ORX64030.1 - 0.036 12.4 0.1 0.047 12.0 0.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CENP-H PF05837.12 ORX64032.1 - 0.0061 17.0 3.4 0.0061 17.0 3.4 3.4 2 1 1 3 3 3 1 Centromere protein H (CENP-H) Laminin_I PF06008.14 ORX64032.1 - 0.011 15.4 3.1 0.011 15.4 3.1 3.1 2 1 1 3 3 3 0 Laminin Domain I GAS PF13851.6 ORX64032.1 - 0.012 14.9 27.7 0.047 13.0 7.3 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF948 PF06103.11 ORX64032.1 - 0.22 11.8 11.6 0.61 10.4 0.2 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 ORX64032.1 - 0.57 9.5 22.3 0.096 12.0 10.9 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Sas6_CC PF18594.1 ORX64032.1 - 0.71 9.7 8.2 0.46 10.3 0.5 2.9 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain DUF4777 PF16007.5 ORX64032.1 - 0.97 9.7 3.1 4.4 7.6 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) Syntaxin_2 PF14523.6 ORX64032.1 - 1.3 9.5 13.4 3.4 8.1 0.9 3.1 2 1 1 3 3 3 0 Syntaxin-like protein Prominin PF05478.11 ORX64032.1 - 1.9 6.3 11.4 1.9 6.4 10.5 1.4 1 1 0 1 1 1 0 Prominin APG6_N PF17675.1 ORX64032.1 - 2.3 8.8 36.5 8 7.0 22.1 3.1 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF489 PF04356.12 ORX64032.1 - 2.7 8.0 9.0 0.19 11.7 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF489) D5_N PF08706.11 ORX64032.1 - 2.8 8.2 8.0 17 5.6 8.0 2.2 1 1 0 1 1 1 0 D5 N terminal like FlaC_arch PF05377.11 ORX64032.1 - 4.2 7.8 11.5 0.91 10.0 1.1 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) SKA1 PF07160.12 ORX64032.1 - 8 6.2 17.3 1.9 8.3 8.3 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 E3_binding PF02817.17 ORX64033.1 - 2.7e-09 37.2 0.0 7.6e-09 35.8 0.0 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 ORX64033.1 - 9.3e-05 22.2 0.2 0.0003 20.6 0.2 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme 2-oxoacid_dh PF00198.23 ORX64033.1 - 0.15 11.5 2.5 2.4 7.5 3.0 2.4 2 1 0 2 2 2 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Xan_ur_permease PF00860.20 ORX64034.1 - 4.4e-13 48.7 24.0 8.3e-10 37.9 7.8 3.5 2 1 1 3 3 3 2 Permease family Xan_ur_permease PF00860.20 ORX64035.1 - 3.2e-24 85.3 31.6 1e-21 77.1 32.2 2.9 2 1 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 ORX64035.1 - 0.016 15.6 6.0 0.016 15.6 6.0 2.9 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily NYD-SP28 PF14772.6 ORX64036.1 - 0.13 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Sperm tail Piwi PF02171.17 ORX64046.1 - 4.3e-23 82.0 0.0 5e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Piwi domain Transgly_assoc PF04226.13 ORX64061.1 - 0.1 12.9 2.0 0.19 12.0 1.4 1.8 1 1 1 2 2 2 0 Transglycosylase associated protein Oxysterol_BP PF01237.18 ORX64062.1 - 2.7e-52 177.8 15.5 4.7e-38 131.0 0.7 3.5 1 1 1 2 2 2 2 Oxysterol-binding protein GOLD_2 PF13897.6 ORX64062.1 - 0.0025 18.3 4.9 0.0043 17.6 0.0 3.2 4 0 0 4 4 4 1 Golgi-dynamics membrane-trafficking RRM_1 PF00076.22 ORX64073.1 - 6.8e-08 32.2 0.0 9.4e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX64073.1 - 0.0099 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RNase_Zc3h12a_2 PF14626.6 ORX64073.1 - 0.048 13.9 0.0 0.06 13.6 0.0 1.1 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain SNF2_N PF00176.23 ORX64074.1 - 4.6e-19 68.3 0.0 5.1e-18 64.9 0.0 2.1 1 1 1 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 ORX64074.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TBX PF12598.8 ORX64074.1 - 2.7 8.8 10.1 4.7 8.1 9.3 1.8 1 1 0 1 1 1 0 T-box transcription factor HSF_DNA-bind PF00447.17 ORX64082.1 - 1.1e-12 48.3 0.3 1.2e-12 48.2 0.3 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 ORX64082.1 - 0.0061 17.0 0.3 0.0083 16.6 0.3 1.4 1 1 0 1 1 1 1 Ets-domain PD40 PF07676.12 ORX64082.1 - 0.026 14.5 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat RuBisCO_small PF00101.20 ORX64082.1 - 0.09 12.8 0.6 1.2 9.1 0.6 2.0 1 1 0 1 1 1 0 Ribulose bisphosphate carboxylase, small chain KID PF02524.14 ORX64082.1 - 0.13 12.4 0.2 0.61 10.4 0.1 2.1 2 0 0 2 2 2 0 KID repeat DUF3484 PF11983.8 ORX64089.1 - 1.9 9.7 6.6 18 6.5 0.3 2.2 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Cu-oxidase_3 PF07732.15 ORX64105.1 - 5.9e-31 106.9 1.4 9.4e-30 103.1 0.2 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX64105.1 - 2.4e-27 95.4 8.0 2e-26 92.3 1.8 4.0 4 1 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX64105.1 - 3.2e-12 46.8 0.0 2.1e-11 44.2 0.0 2.3 3 0 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ORX64105.1 - 0.095 12.8 0.0 11 6.2 0.0 2.8 3 0 0 3 3 3 0 Cupredoxin-like domain Cu-oxidase PF00394.22 ORX64106.1 - 6.6e-20 71.8 0.0 1.3e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX64106.1 - 9.8e-16 57.7 1.3 1.8e-14 53.6 1.2 2.7 2 2 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX64106.1 - 1.7e-07 31.3 0.0 3.9e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase DAO PF01266.24 ORX64112.1 - 8.7e-38 130.8 0.0 2.1e-37 129.5 0.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX64112.1 - 0.0019 17.5 0.0 0.45 9.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX64112.1 - 0.069 13.1 0.0 11 6.0 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding Aminotran_1_2 PF00155.21 ORX64126.1 - 1e-11 44.7 0.0 1.1e-11 44.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Sulfate_transp PF00916.20 ORX64129.1 - 8.6e-109 363.8 14.9 1.1e-108 363.4 14.9 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX64129.1 - 3.7e-09 36.2 0.0 6.9e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX64129.1 - 0.00061 20.2 10.2 0.0053 17.1 3.7 3.1 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ORX64129.1 - 0.19 12.1 0.0 0.43 10.9 0.0 1.5 1 0 0 1 1 1 0 STAS domain Pkinase PF00069.25 ORX64135.1 - 6.8e-12 45.3 0.0 9.1e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX64135.1 - 1.8e-06 27.4 0.0 2.1e-06 27.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DnaB_C PF03796.15 ORX64135.1 - 0.08 12.3 0.0 0.091 12.1 0.0 1.0 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Histone PF00125.24 ORX64143.1 - 9.1e-15 55.2 0.8 1.8e-14 54.2 0.8 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX64143.1 - 0.071 13.4 0.6 0.071 13.4 0.6 2.0 2 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pox_A6 PF04924.12 ORX64143.1 - 0.084 11.8 0.0 0.1 11.5 0.0 1.0 1 0 0 1 1 1 0 Poxvirus A6 protein ABC_tran PF00005.27 ORX64158.1 - 1.5e-45 155.0 0.0 4.1e-27 95.4 0.0 3.0 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX64158.1 - 4.1e-08 32.9 0.4 0.0074 15.8 0.3 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX64158.1 - 1.7e-05 24.9 0.2 0.0074 16.4 0.0 3.5 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX64158.1 - 0.00041 20.8 0.1 0.36 11.2 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX64158.1 - 0.023 14.6 0.6 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 ORX64158.1 - 0.023 14.8 0.4 0.054 13.6 0.4 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain MeaB PF03308.16 ORX64158.1 - 0.024 13.6 0.3 1.4 7.8 0.2 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_21 PF13304.6 ORX64158.1 - 0.044 13.6 1.3 1.2 8.8 0.1 3.2 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX64158.1 - 0.064 13.0 1.6 1.6 8.6 0.2 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 ORX64158.1 - 0.091 12.8 0.9 16 5.6 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FKBP_N_2 PF18023.1 ORX64158.1 - 0.14 12.3 0.0 0.61 10.2 0.0 2.0 2 0 0 2 2 2 0 BDBT FKBP like N-terminal IstB_IS21 PF01695.17 ORX64158.1 - 0.19 11.5 1.0 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 IstB-like ATP binding protein Dynamin_N PF00350.23 ORX64158.1 - 0.22 11.5 0.9 16 5.5 0.0 2.5 2 0 0 2 2 2 0 Dynamin family AAA_22 PF13401.6 ORX64158.1 - 0.24 11.7 0.6 4.4 7.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 ORX64158.1 - 1.3 8.1 3.9 48 3.0 0.2 3.4 3 0 0 3 3 3 0 NB-ARC domain Peptidase_M3 PF01432.20 ORX64160.1 - 1.3e-61 209.3 3.0 1.3e-29 103.8 0.0 3.3 1 1 1 2 2 2 2 Peptidase family M3 Glyco_hydro_46 PF01374.18 ORX64169.1 - 3.4e-45 154.3 3.2 1.3e-44 152.4 3.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 Pirin_C PF05726.13 ORX64170.1 - 2.1e-23 82.7 0.0 3.8e-23 81.8 0.0 1.4 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX64170.1 - 5.4e-05 23.1 0.3 0.00012 22.0 0.3 1.6 1 0 0 1 1 1 1 Pirin DUF1254 PF06863.12 ORX64170.1 - 0.021 14.9 0.0 0.055 13.5 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1254) ABC_tran PF00005.27 ORX64171.1 - 5.5e-14 52.8 0.0 1.1e-13 51.9 0.0 1.5 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX64171.1 - 0.2 11.1 0.0 0.92 8.9 0.0 1.8 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain Pirin_C PF05726.13 ORX64173.1 - 2.8e-09 37.2 0.1 1.7e-08 34.7 0.1 2.1 1 1 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX64173.1 - 3.3e-05 23.8 0.5 9.1e-05 22.4 0.3 1.9 2 0 0 2 2 2 1 Pirin Acid_PPase PF12689.7 ORX64188.1 - 1.2e-28 100.1 2.7 2.8e-14 53.3 0.1 3.0 1 1 2 3 3 3 3 Acid Phosphatase ABC_membrane PF00664.23 ORX64189.1 - 0.0024 17.6 3.6 0.039 13.6 0.3 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region SGL PF08450.12 ORX64195.1 - 1.3e-32 113.4 0.8 1.9e-31 109.6 0.2 2.5 2 1 2 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ORX64195.1 - 0.00037 20.4 3.3 55 4.1 0.0 5.4 5 0 0 5 5 5 0 NHL repeat Phytase-like PF13449.6 ORX64195.1 - 0.0028 17.6 0.1 0.072 13.0 0.0 2.3 1 1 0 2 2 2 1 Esterase-like activity of phytase Arylesterase PF01731.20 ORX64195.1 - 0.0042 17.3 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 1 Arylesterase PQQ_2 PF13360.6 ORX64195.1 - 0.014 14.9 0.2 5.3 6.5 0.0 2.7 2 1 1 3 3 3 0 PQQ-like domain SBBP PF06739.11 ORX64195.1 - 0.077 13.0 0.5 7.1 6.7 0.1 3.0 2 0 0 2 2 2 0 Beta-propeller repeat SspP PF08179.12 ORX64217.1 - 0.18 12.3 0.3 0.58 10.6 0.0 1.9 2 0 0 2 2 2 0 Small acid-soluble spore protein P family FMN_red PF03358.15 ORX64219.1 - 2.3e-13 50.2 0.0 3.4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX64219.1 - 1.7e-07 31.2 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX64219.1 - 0.00078 19.7 0.0 0.0022 18.2 0.0 1.7 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX64219.1 - 0.043 14.1 0.0 11 6.2 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain TrbL PF04610.14 ORX64220.1 - 0.1 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein F-box-like PF12937.7 ORX64237.1 - 0.044 13.7 0.3 0.39 10.6 0.0 2.9 3 0 0 3 3 3 0 F-box-like JTB PF05439.12 ORX64238.1 - 1.5e-06 28.2 0.6 2.6e-06 27.4 0.6 1.4 1 1 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Glyco_hydro_18 PF00704.28 ORX64248.1 - 2.3e-55 188.5 0.6 2.8e-55 188.2 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX64248.1 - 0.0033 17.4 1.1 0.011 15.8 1.1 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX64248.1 - 0.12 12.5 0.8 0.29 11.3 0.8 1.7 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Tail_VII PF17091.5 ORX64249.1 - 2.9 7.8 6.0 12 5.9 0.1 2.8 3 0 0 3 3 3 0 Inovirus G7P protein Cu-oxidase_3 PF07732.15 ORX64254.1 - 2.6e-39 133.9 3.2 7.8e-34 116.2 0.4 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX64254.1 - 2e-20 72.9 3.4 7.6e-13 48.4 0.0 4.2 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX64254.1 - 3.6e-20 72.7 0.1 1.3e-16 61.1 0.0 3.0 2 1 0 2 2 2 2 Multicopper oxidase DUF5522 PF17653.1 ORX64256.1 - 3.3e-12 46.1 1.0 3.2e-11 43.0 1.0 2.1 1 1 0 1 1 1 1 Family of unknown function (DUF5522) DUF807 PF05660.11 ORX64256.1 - 0.03 14.3 0.0 0.035 14.1 0.0 1.1 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) HC2 PF07382.11 ORX64273.1 - 0.088 12.9 29.8 2.3 8.3 14.5 2.5 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 SDP_N PF12278.8 ORX64273.1 - 1 9.5 3.8 2.4 8.3 3.8 1.6 1 0 0 1 1 1 0 Sex determination protein N terminal Sugar_tr PF00083.24 ORX64274.1 - 6.2e-40 137.4 26.6 5.6e-20 71.6 0.7 3.3 2 2 1 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 ORX64274.1 - 2e-06 27.0 36.8 0.0002 20.4 4.3 3.2 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF3792 PF12670.7 ORX64274.1 - 0.0091 16.2 7.7 0.0091 16.2 7.7 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3792) Haem_oxygenas_2 PF14518.6 ORX64274.1 - 0.048 13.4 0.1 0.087 12.6 0.1 1.4 1 0 0 1 1 1 0 Iron-containing redox enzyme Haemagg_act PF05860.13 ORX64274.1 - 0.16 11.9 0.5 0.35 10.7 0.0 1.8 2 0 0 2 2 2 0 haemagglutination activity domain TPR_12 PF13424.6 ORX64286.1 - 3.6e-09 36.8 15.4 0.0012 19.1 0.1 4.2 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX64286.1 - 3.2e-07 29.9 8.5 0.0093 16.0 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX64286.1 - 5.2e-05 23.0 5.6 2.6 8.3 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX64286.1 - 7.3e-05 22.5 12.5 0.93 9.5 0.1 4.8 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX64286.1 - 7.7e-05 23.1 15.7 0.018 15.5 1.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX64286.1 - 0.00014 22.4 24.1 1 10.4 2.4 5.3 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX64286.1 - 0.00015 21.4 0.6 0.1 12.5 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX64286.1 - 0.00082 19.4 3.0 0.41 11.0 0.2 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX64286.1 - 0.021 15.4 26.9 0.22 12.2 6.8 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat ABA_WDS PF02496.16 ORX64286.1 - 0.079 13.4 0.0 0.23 12.0 0.0 1.7 1 0 0 1 1 1 0 ABA/WDS induced protein TPR_5 PF12688.7 ORX64286.1 - 0.47 10.7 6.5 0.74 10.1 0.4 3.2 2 1 1 3 3 3 0 Tetratrico peptide repeat Peptidase_C27 PF05407.12 ORX64286.1 - 1.2 9.2 6.5 0.19 11.8 0.4 2.6 2 1 0 3 3 3 0 Rubella virus endopeptidase TPR_6 PF13174.6 ORX64286.1 - 8.4 7.3 14.2 64 4.5 0.3 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat Mog1 PF04603.12 ORX64287.1 - 4.8e-39 133.9 0.1 5.4e-39 133.7 0.1 1.0 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SPACA9 PF15120.6 ORX64287.1 - 0.14 11.9 0.1 0.31 10.8 0.0 1.6 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 RNA_pol_Rpc4 PF05132.14 ORX64288.1 - 3.5e-22 79.4 0.7 6.2e-22 78.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase III RPC4 DUF2722 PF10846.8 ORX64296.1 - 0.0084 15.1 26.7 0.0076 15.3 26.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) FYVE PF01363.21 ORX64296.1 - 0.018 15.1 13.1 0.018 15.1 13.1 2.5 2 2 0 2 2 1 0 FYVE zinc finger Rxt3 PF08642.10 ORX64296.1 - 0.044 14.6 2.5 0.04 14.7 2.5 1.1 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 ORX64296.1 - 0.056 12.9 8.4 0.049 13.1 8.4 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF4471 PF14740.6 ORX64296.1 - 0.095 11.9 5.2 0.088 12.0 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) U3_snoRNA_assoc PF08297.11 ORX64296.1 - 0.11 13.3 5.5 0.13 13.0 5.5 1.1 1 0 0 1 1 1 0 U3 snoRNA associated FAM176 PF14851.6 ORX64296.1 - 0.11 12.1 3.8 0.11 12.1 3.8 1.2 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 ORX64296.1 - 0.13 12.2 31.7 0.13 12.3 31.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYVE_2 PF02318.16 ORX64296.1 - 0.14 12.4 18.4 0.16 12.2 18.4 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger MecA PF05389.12 ORX64296.1 - 0.14 11.7 7.2 0.13 11.8 7.2 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Tim54 PF11711.8 ORX64296.1 - 0.14 10.9 5.8 0.13 11.0 5.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 ORX64296.1 - 0.15 12.2 7.8 0.14 12.3 7.8 1.1 1 0 0 1 1 1 0 DDHD domain TERB2 PF15101.6 ORX64296.1 - 0.21 11.6 16.7 0.24 11.5 16.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4770 PF15994.5 ORX64296.1 - 0.25 11.6 11.0 0.22 11.7 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) tRNA_lig_CPD PF08302.11 ORX64296.1 - 0.29 10.5 9.8 0.33 10.4 9.8 1.1 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain Presenilin PF01080.17 ORX64296.1 - 0.31 9.7 10.8 0.3 9.8 10.8 1.1 1 0 0 1 1 1 0 Presenilin PepSY_TM PF03929.16 ORX64296.1 - 0.31 10.6 3.0 0.27 10.9 3.0 1.0 1 0 0 1 1 1 0 PepSY-associated TM region CPSF100_C PF13299.6 ORX64296.1 - 0.36 11.0 7.9 0.39 10.9 7.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EPL1 PF10513.9 ORX64296.1 - 0.37 11.2 9.8 0.34 11.3 9.8 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF4638 PF15472.6 ORX64296.1 - 0.43 10.3 7.9 0.42 10.3 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF2828 PF11443.8 ORX64296.1 - 0.75 7.8 7.6 0.69 7.9 7.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF719 PF05334.13 ORX64296.1 - 0.81 9.9 10.0 0.91 9.7 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) BAT2_N PF07001.11 ORX64296.1 - 0.95 9.9 14.0 0.98 9.8 14.0 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Med15 PF09606.10 ORX64296.1 - 0.96 8.1 31.2 0.94 8.1 31.2 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Gti1_Pac2 PF09729.9 ORX64296.1 - 1.2 9.2 8.7 1.1 9.3 8.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family FHIPEP PF00771.20 ORX64296.1 - 1.7 7.0 8.0 1.6 7.1 8.0 1.0 1 0 0 1 1 1 0 FHIPEP family Orf78 PF06024.12 ORX64296.1 - 1.7 9.0 7.9 2.1 8.7 7.9 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF3408 PF11888.8 ORX64296.1 - 1.7 8.7 11.4 1.9 8.6 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) TMEM51 PF15345.6 ORX64296.1 - 1.8 8.4 15.3 1.8 8.3 15.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 Ureide_permease PF07168.11 ORX64296.1 - 2.3 6.9 4.6 2.2 7.0 4.6 1.1 1 0 0 1 1 1 0 Ureide permease DUF775 PF05603.12 ORX64296.1 - 2.3 7.7 14.0 2.4 7.7 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) MMR1 PF08505.10 ORX64296.1 - 2.3 8.4 14.5 2.3 8.5 14.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CSG2 PF16965.5 ORX64296.1 - 2.5 6.9 6.1 2.7 6.8 6.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Band_3_cyto PF07565.13 ORX64296.1 - 3 7.6 10.4 2.8 7.7 10.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PAT1 PF09770.9 ORX64296.1 - 3 6.0 22.2 2.8 6.1 22.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ctr PF04145.15 ORX64296.1 - 3.6 8.2 7.2 3.6 8.2 7.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family RED_N PF07808.13 ORX64296.1 - 4.4 6.8 15.2 4.6 6.8 15.2 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region ALMT PF11744.8 ORX64296.1 - 4.6 6.0 9.1 4.3 6.1 9.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 ORX64296.1 - 4.8 6.1 9.3 4.8 6.1 9.3 1.1 1 0 0 1 1 1 0 CLN3 protein Spt20 PF12090.8 ORX64296.1 - 4.8 6.7 44.0 5.8 6.4 44.0 1.2 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 ORX64296.1 - 4.8 8.2 17.0 7 7.7 17.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EIIBC-GUT_N PF03612.14 ORX64296.1 - 4.9 6.9 13.4 6.2 6.5 13.4 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Folate_carrier PF01770.18 ORX64296.1 - 5.1 5.7 8.2 5.2 5.7 8.2 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF3371 PF11851.8 ORX64296.1 - 5.1 8.2 16.2 6.2 7.9 16.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Pex14_N PF04695.13 ORX64296.1 - 5.4 7.6 24.1 6 7.5 24.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SRRM_C PF15230.6 ORX64296.1 - 5.5 7.6 7.6 9 7.0 7.6 1.3 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus UPF0560 PF10577.9 ORX64296.1 - 6.3 5.2 21.8 6.8 5.1 21.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 BRF1 PF07741.13 ORX64296.1 - 7.6 7.0 14.2 9.9 6.6 14.2 1.2 1 1 0 1 1 1 0 Brf1-like TBP-binding domain Peptidase_S49_N PF08496.10 ORX64296.1 - 8.6 6.4 10.3 9.8 6.2 10.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ABC2_membrane_2 PF12679.7 ORX64296.1 - 8.9 5.5 7.1 8.2 5.6 7.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein VIT1 PF01988.19 ORX64296.1 - 9.7 6.0 6.1 11 5.9 6.1 1.1 1 0 0 1 1 1 0 VIT family DUF853 PF05872.12 ORX64296.1 - 9.8 4.6 10.5 9.8 4.6 10.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Nop10p PF04135.12 ORX64297.1 - 9.8e-17 60.7 1.0 1.5e-16 60.2 1.0 1.3 1 1 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family TrbL PF04610.14 ORX64298.1 - 0.095 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein FMN_red PF03358.15 ORX64299.1 - 9.4e-14 51.4 0.0 1.4e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX64299.1 - 9.7e-08 31.9 0.0 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX64299.1 - 0.00078 19.7 0.0 0.0025 18.0 0.0 1.8 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX64299.1 - 0.03 14.6 0.0 9.3 6.5 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain TT_ORF2 PF02957.15 ORX64300.1 - 0.072 14.0 0.3 0.072 14.0 0.3 2.2 2 1 1 3 3 3 0 TT viral ORF2 Pkinase PF00069.25 ORX64304.1 - 8.8e-11 41.7 0.2 3.7e-10 39.6 0.2 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX64304.1 - 3.4e-06 26.5 0.1 6.6e-06 25.6 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase NDK PF00334.19 ORX64305.1 - 3.3e-96 318.5 0.0 1.9e-39 134.8 0.0 3.5 3 0 0 3 3 3 3 Nucleoside diphosphate kinase TRAPPC9-Trs120 PF08626.11 ORX64329.1 - 7.4e-07 26.9 0.0 8.9e-07 26.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Peptidase_M36 PF02128.15 ORX64333.1 - 3.3e-154 513.5 3.1 4.3e-154 513.2 3.1 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX64333.1 - 3.1e-12 46.1 2.8 3.1e-12 46.1 2.8 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX64333.1 - 1.3e-05 25.1 0.1 3.3e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX64333.1 - 0.098 12.9 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain RabGAP-TBC PF00566.18 ORX64334.1 - 1.1e-11 44.8 0.0 1.2e-11 44.7 0.0 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase_fungal PF17667.1 ORX64363.1 - 4.1e-14 52.2 0.0 3.7e-09 35.9 0.0 3.3 2 1 0 3 3 3 3 Fungal protein kinase APH PF01636.23 ORX64363.1 - 2.5e-05 24.3 0.1 2.5e-05 24.3 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 ORX64363.1 - 0.047 13.1 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Ribosomal_L1 PF00687.21 ORX64371.1 - 4.9e-40 137.5 3.7 1.3e-38 132.8 3.7 2.0 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family TFIIS_C PF01096.18 ORX64372.1 - 3.4e-17 62.0 5.6 3.4e-17 62.0 5.6 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX64372.1 - 1.7e-08 34.2 2.2 1.7e-08 34.2 2.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ORX64372.1 - 0.019 14.9 2.7 0.019 14.9 2.7 2.9 2 2 1 3 3 3 0 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.10 ORX64372.1 - 0.021 14.6 0.6 0.021 14.6 0.6 1.9 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger zf-UBR PF02207.20 ORX64383.1 - 1.7e-19 69.7 13.3 5.4e-19 68.1 13.3 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 ORX64383.1 - 3.1e-09 36.5 0.1 7.2e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS DUF726 PF05277.12 ORX64392.1 - 1.9e-10 40.2 0.0 2.3e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Malic_M PF03949.15 ORX64407.1 - 3e-54 184.0 3.5 1.9e-52 178.1 2.2 3.1 2 1 0 2 2 2 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX64407.1 - 4.4e-54 183.1 0.0 6.8e-54 182.4 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DUF4798 PF16055.5 ORX64407.1 - 0.071 13.4 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) DUF2203 PF09969.9 ORX64418.1 - 0.0063 17.2 0.3 0.0074 17.0 0.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) SbcD_C PF12320.8 ORX64418.1 - 0.033 14.5 0.2 0.036 14.4 0.2 1.1 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain Ras PF00071.22 ORX64428.1 - 1e-25 90.2 0.1 3.2e-23 82.1 0.1 2.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ORX64428.1 - 1e-07 32.2 0.0 1.2e-05 25.5 0.0 2.2 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX64428.1 - 0.03 13.8 0.0 0.33 10.4 0.0 2.4 1 1 0 2 2 2 0 ADP-ribosylation factor family HTH_28 PF13518.6 ORX64430.1 - 0.044 13.9 0.1 0.078 13.1 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DEAD PF00270.29 ORX64447.1 - 1.6e-35 122.4 0.1 4.5e-35 121.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX64447.1 - 4.6e-18 65.6 0.2 2.6e-17 63.2 0.1 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX64447.1 - 0.0098 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ORX64447.1 - 0.086 11.5 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.6 ORX64447.1 - 0.16 12.3 0.2 0.66 10.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain OPT PF03169.15 ORX64458.1 - 3.2e-05 22.8 0.0 3.6e-05 22.6 0.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein COPI_assoc PF08507.10 ORX64459.1 - 0.086 12.9 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 COPI associated protein Sugar_tr PF00083.24 ORX64468.1 - 1.7e-87 294.2 25.3 2.1e-87 293.9 25.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX64468.1 - 5.2e-25 88.1 47.5 5.2e-20 71.7 13.8 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF2398 PF09661.10 ORX64468.1 - 0.0074 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2398) Ninjurin PF04923.12 ORX64468.1 - 0.15 12.0 1.3 0.51 10.3 1.3 1.9 1 0 0 1 1 1 0 Ninjurin Trp_oprn_chp PF09534.10 ORX64468.1 - 0.19 11.5 3.8 0.098 12.4 0.3 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Cytochrom_C_asm PF01578.20 ORX64468.1 - 0.65 9.7 16.6 0.13 12.0 0.3 2.8 2 1 1 3 3 3 0 Cytochrome C assembly protein Gly-zipper_YMGG PF13441.6 ORX64468.1 - 2.4 8.0 9.3 0.69 9.7 1.8 3.4 2 2 0 2 2 2 0 YMGG-like Gly-zipper Transferase PF02458.15 ORX64469.1 - 1.4e-11 43.8 0.0 8.8e-09 34.5 0.0 2.3 2 1 0 2 2 2 2 Transferase family ABC_tran PF00005.27 ORX64471.1 - 5.4e-29 101.5 0.0 9.6e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX64471.1 - 8.8e-29 101.0 11.2 1.2e-28 100.5 11.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX64471.1 - 8.8e-05 22.0 1.1 0.0012 18.3 0.0 2.6 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ORX64471.1 - 0.0051 15.9 0.0 0.0092 15.1 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 ORX64471.1 - 0.028 14.8 0.1 0.074 13.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX64471.1 - 0.04 14.2 0.1 4.7 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ORX64471.1 - 0.044 13.6 2.1 2 8.2 0.3 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ORX64471.1 - 0.053 13.0 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ORX64471.1 - 0.1 12.7 0.1 0.29 11.2 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase PDR_assoc PF08370.11 ORX64471.1 - 0.1 12.3 4.7 0.77 9.5 0.2 2.9 2 0 0 2 2 2 0 Plant PDR ABC transporter associated AAA_29 PF13555.6 ORX64471.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PufQ PF05398.11 ORX64479.1 - 0.84 9.8 2.7 0.61 10.3 0.1 2.0 2 0 0 2 2 2 0 PufQ cytochrome subunit Aldedh PF00171.22 ORX64482.1 - 1.6e-115 386.3 0.1 7.1e-114 380.8 0.1 2.7 1 1 0 1 1 1 1 Aldehyde dehydrogenase family TPR_12 PF13424.6 ORX64484.1 - 1.6e-07 31.5 8.5 0.055 13.8 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX64484.1 - 3.7e-07 30.4 1.5 4.9 8.2 0.0 7.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX64484.1 - 9.9e-07 28.4 3.4 0.54 10.5 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX64484.1 - 2.9e-06 26.8 0.0 1.3 9.0 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX64484.1 - 8.3e-05 22.3 1.6 1.1 9.2 0.2 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX64484.1 - 0.00015 21.6 0.8 5.1 7.4 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX64484.1 - 0.0032 17.7 0.1 0.19 12.0 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ORX64484.1 - 0.069 13.4 4.2 0.36 11.2 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat PNK3P PF08645.11 ORX64485.1 - 1.7e-42 144.8 0.0 2.5e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ORX64485.1 - 1.6e-12 47.8 0.0 1.3e-08 35.1 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ORX64485.1 - 0.022 15.2 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Hydrolase_6 PF13344.6 ORX64485.1 - 0.032 14.3 0.0 0.083 13.0 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase CobU PF02283.16 ORX64485.1 - 0.038 13.5 0.0 8.9 5.9 0.0 2.2 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase 6PF2K PF01591.18 ORX64485.1 - 0.074 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 ORX64485.1 - 0.091 13.1 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain HAD PF12710.7 ORX64485.1 - 0.11 12.9 0.0 0.29 11.5 0.0 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase KTI12 PF08433.10 ORX64485.1 - 0.11 11.9 0.3 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ORX64485.1 - 0.12 11.7 0.0 0.38 10.0 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin FAD_binding_2 PF00890.24 ORX64486.1 - 1.7e-85 287.7 15.9 1.1e-83 281.7 15.9 2.1 1 1 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ORX64486.1 - 3e-43 146.8 2.1 5.1e-43 146.1 2.1 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.17 ORX64486.1 - 8.3e-05 21.9 0.6 0.26 10.5 0.2 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 ORX64486.1 - 0.00075 18.8 1.7 0.0031 16.8 0.6 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX64486.1 - 0.0016 17.6 0.4 0.0041 16.3 0.4 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ORX64486.1 - 0.043 13.1 0.5 1.4 8.1 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ubiquitin PF00240.23 ORX64487.1 - 3.9e-16 58.6 1.8 6.9e-14 51.4 1.8 2.0 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX64487.1 - 1.5e-09 37.6 1.2 7.3e-07 28.9 1.2 2.0 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ORX64487.1 - 0.022 14.8 0.4 0.048 13.7 0.4 1.6 1 1 1 2 2 2 0 Ubiquitin-like domain TPR_17 PF13431.6 ORX64488.1 - 0.02 15.2 0.8 1.6 9.3 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_inhib PF16857.5 ORX64488.1 - 0.072 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase inhibitor TPR_7 PF13176.6 ORX64488.1 - 0.16 12.1 3.1 26 5.1 0.0 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat HMG_CoA_synt_C PF08540.10 ORX64489.1 - 1.2e-93 313.8 0.6 1.7e-93 313.3 0.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 ORX64489.1 - 9.9e-87 289.3 0.8 1.5e-86 288.7 0.8 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal RNaseH_like PF04308.12 ORX64489.1 - 0.11 12.4 0.1 0.31 11.0 0.0 1.8 2 0 0 2 2 2 0 Ribonuclease H-like PI-PLC-C1 PF16670.5 ORX64490.1 - 0.00023 20.4 0.1 0.44 9.6 0.0 2.6 2 1 1 3 3 3 2 Phosphoinositide phospholipase C, Ca2+-dependent DUF957 PF06117.11 ORX64490.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) PI-PLC-X PF00388.19 ORX64490.1 - 0.081 12.5 0.0 0.17 11.5 0.0 1.6 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Helicase_C PF00271.31 ORX64491.1 - 6.9e-28 97.2 0.0 1.8e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX64491.1 - 1.1e-20 74.1 0.0 6.6e-18 65.1 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Q_salvage PF10343.9 ORX64492.1 - 2.1e-86 290.0 0.2 2.6e-85 286.4 0.2 2.0 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Bcl-2 PF00452.19 ORX64492.1 - 0.033 14.9 0.3 0.085 13.6 0.1 1.8 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family DUF1688 PF07958.11 ORX64492.1 - 0.13 10.9 0.0 7.9 5.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1688) p450 PF00067.22 ORX64493.1 - 1.3e-54 185.8 0.7 4.3e-38 131.2 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 p450 PF00067.22 ORX64494.1 - 2.4e-37 128.8 0.0 3.8e-28 98.5 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 E1-E2_ATPase PF00122.20 ORX64506.1 - 5.3e-42 143.4 2.2 5.3e-42 143.4 2.2 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX64506.1 - 3.4e-38 131.2 9.6 3.4e-38 131.2 9.6 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX64506.1 - 1.9e-19 70.8 0.2 2.1e-07 31.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX64506.1 - 3.5e-11 43.0 0.0 9.7e-11 41.6 0.0 1.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX64506.1 - 1.1e-09 37.8 0.0 2.7e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX64506.1 - 5.2e-08 32.9 0.3 1.2e-07 31.8 0.3 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LSM PF01423.22 ORX64507.1 - 5.4e-09 35.6 0.0 6.5e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain RL PF17797.1 ORX64508.1 - 0.2 11.6 0.3 0.4 10.7 0.3 1.4 1 0 0 1 1 1 0 RL domain Sugar_tr PF00083.24 ORX64529.1 - 2.9e-96 323.1 23.7 3.6e-96 322.8 23.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX64529.1 - 2.9e-32 112.0 60.6 1.2e-29 103.3 27.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX64529.1 - 0.00029 19.4 2.9 0.00029 19.4 2.9 2.4 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ORX64529.1 - 0.19 10.2 32.8 0.058 11.9 1.2 3.5 2 2 1 3 3 3 0 MFS/sugar transport protein DUF4231 PF14015.6 ORX64529.1 - 7.1 7.2 7.5 0.87 10.1 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Pkinase PF00069.25 ORX64541.1 - 4.1e-31 108.3 0.1 2e-30 106.1 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX64541.1 - 9.8e-13 48.0 0.0 1.3e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RskA PF10099.9 ORX64541.1 - 0.072 13.4 7.7 0.12 12.7 7.7 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Adeno_PIX PF03955.14 ORX64541.1 - 0.077 13.2 3.3 0.16 12.1 3.3 1.6 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) PTR2 PF00854.21 ORX64543.1 - 3.5e-96 322.4 6.3 4.5e-96 322.1 6.3 1.2 1 0 0 1 1 1 1 POT family DUF5134 PF17197.4 ORX64543.1 - 0.09 12.7 0.3 0.17 11.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) DUF2104 PF09877.9 ORX64543.1 - 0.095 13.0 0.9 0.3 11.4 0.9 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2104) Peptidase_U4 PF03419.13 ORX64543.1 - 0.73 9.1 5.1 0.077 12.3 0.5 1.8 2 0 0 2 2 2 0 Sporulation factor SpoIIGA AAA PF00004.29 ORX64544.1 - 1.6e-41 141.9 0.0 4.1e-41 140.5 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ORX64544.1 - 2.8e-28 97.7 0.5 7.2e-28 96.4 0.1 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ORX64544.1 - 1.1e-23 83.1 8.4 2.5e-23 81.9 8.4 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 ORX64544.1 - 1.7e-07 30.9 0.0 9.2e-07 28.6 0.0 2.2 2 0 0 2 2 2 1 AAA+ lid domain AAA_2 PF07724.14 ORX64544.1 - 7.1e-06 26.2 0.1 0.0046 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX64544.1 - 7.8e-06 26.4 0.1 0.00065 20.1 0.0 2.7 2 1 0 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX64544.1 - 1.9e-05 24.7 0.0 7e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX64544.1 - 3.7e-05 23.5 0.0 6.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ORX64544.1 - 4.2e-05 22.9 0.0 0.00016 21.0 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain USP8_dimer PF08969.11 ORX64544.1 - 6.2e-05 23.1 5.4 0.00013 22.2 5.4 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain RNA_helicase PF00910.22 ORX64544.1 - 8.2e-05 23.0 0.1 0.011 16.1 0.0 3.3 3 1 1 4 4 3 1 RNA helicase AAA_22 PF13401.6 ORX64544.1 - 0.00011 22.5 0.2 0.0057 16.9 0.0 2.8 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ORX64544.1 - 0.00013 21.7 0.0 0.0003 20.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 ORX64544.1 - 0.00037 19.8 0.0 0.003 16.7 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 ORX64544.1 - 0.0011 19.1 0.3 0.0036 17.5 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.6 ORX64544.1 - 0.0015 19.1 0.1 0.006 17.1 0.0 2.1 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.6 ORX64544.1 - 0.0016 18.5 0.0 0.005 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX64544.1 - 0.0033 17.8 0.2 0.077 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX64544.1 - 0.0059 16.4 0.6 0.027 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX64544.1 - 0.031 13.8 0.0 0.096 12.2 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Use1 PF09753.9 ORX64544.1 - 0.037 13.8 1.6 0.068 12.9 1.6 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 Mg_chelatase PF01078.21 ORX64544.1 - 0.039 13.3 0.0 0.087 12.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ORX64544.1 - 0.046 13.6 1.1 1.1 9.1 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea WASH_WAHD PF11945.8 ORX64544.1 - 0.05 13.1 0.2 0.081 12.4 0.2 1.2 1 0 0 1 1 1 0 WAHD domain of WASH complex AAA_25 PF13481.6 ORX64544.1 - 0.05 13.2 0.1 0.75 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ORX64544.1 - 0.052 12.6 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 ORX64544.1 - 0.053 13.4 0.0 0.44 10.4 0.0 2.3 1 1 1 2 2 2 0 NACHT domain PhdYeFM_antitox PF02604.19 ORX64544.1 - 0.067 13.0 0.5 0.46 10.3 0.1 2.6 2 1 1 3 3 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system ATPase PF06745.13 ORX64544.1 - 0.086 12.2 0.0 5.7 6.2 0.0 2.4 1 1 0 2 2 2 0 KaiC PhoH PF02562.16 ORX64544.1 - 0.13 11.7 1.2 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein Torsin PF06309.11 ORX64544.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Torsin TPR_1 PF00515.28 ORX64544.1 - 0.41 10.6 2.7 1.5 8.8 2.5 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX64544.1 - 0.47 10.7 2.6 1.5 9.1 1.0 2.7 2 1 1 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.25 ORX64545.1 - 2.9e-64 217.0 0.0 3.4e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX64545.1 - 1.6e-31 109.6 0.0 2e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX64545.1 - 0.0027 17.1 0.0 0.0054 16.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX64545.1 - 0.007 15.2 0.1 0.012 14.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX64545.1 - 0.03 13.7 0.1 0.048 13.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adeno_PIX PF03955.14 ORX64545.1 - 0.081 13.1 3.0 0.2 11.8 3.0 1.7 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) RskA PF10099.9 ORX64545.1 - 0.17 12.2 8.2 0.27 11.5 8.2 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA zf-C2H2 PF00096.26 ORX64576.1 - 0.018 15.5 0.2 0.034 14.6 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX64576.1 - 0.029 15.2 0.4 0.061 14.2 0.4 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger IlvB_leader PF08049.11 ORX64585.1 - 1.9 8.5 5.4 4.3 7.4 5.4 1.6 1 0 0 1 1 1 0 IlvB leader peptide FAR1 PF03101.15 ORX64592.1 - 0.00015 22.4 1.5 0.00027 21.6 1.5 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain Mur_ligase_M PF08245.12 ORX64601.1 - 0.081 12.9 0.0 1.6 8.7 0.0 2.6 2 1 0 2 2 2 0 Mur ligase middle domain Plasmodium_HRP PF05403.11 ORX64603.1 - 0.13 12.1 9.2 0.15 11.9 9.2 1.1 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) PRAS PF15798.5 ORX64603.1 - 0.18 12.4 1.0 0.21 12.2 1.0 1.2 1 0 0 1 1 1 0 Proline-rich AKT1 substrate 1 LAMTOR5 PF16672.5 ORX64604.1 - 1.9e-12 46.9 0.0 2.1e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Robl_LC7 PF03259.17 ORX64604.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Roadblock/LC7 domain ADH_N_2 PF16884.5 ORX64625.1 - 1.7e-10 40.8 0.0 4e-10 39.5 0.0 1.4 1 1 1 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ORX64625.1 - 0.00029 20.8 0.0 0.0004 20.4 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sporozoite_P67 PF05642.11 ORX64626.1 - 0.36 8.9 5.4 0.39 8.8 5.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen F-box-like PF12937.7 ORX64639.1 - 0.013 15.4 0.2 0.013 15.4 0.2 2.4 3 0 0 3 3 3 0 F-box-like F-box PF00646.33 ORX64639.1 - 0.27 11.2 0.1 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 F-box domain Glutaredoxin PF00462.24 ORX64641.1 - 4e-11 43.0 0.0 5.4e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ORX64641.1 - 0.16 12.4 0.0 0.21 12.0 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain PNP_UDP_1 PF01048.20 ORX64642.1 - 1.1e-26 93.6 0.3 1.6e-22 80.0 0.0 2.2 1 1 1 2 2 2 2 Phosphorylase superfamily Pirin_C PF05726.13 ORX64656.1 - 3.4e-18 65.9 0.0 5.6e-18 65.2 0.0 1.5 1 1 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX64656.1 - 4.8e-05 23.3 0.3 0.00011 22.2 0.3 1.6 1 0 0 1 1 1 1 Pirin Phage_int_SAM_4 PF13495.6 ORX64672.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain RNA_pol_N PF01194.17 ORX64673.1 - 0.028 14.7 2.0 0.16 12.3 2.0 2.0 1 1 0 1 1 1 0 RNA polymerases N / 8 kDa subunit FMN_red PF03358.15 ORX64680.1 - 3.5e-12 46.3 0.0 5.3e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX64680.1 - 5.9e-05 22.9 0.0 8.5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Peptidase_S8 PF00082.22 ORX64684.1 - 4.4e-45 154.2 0.0 5.2e-34 117.9 0.0 3.0 1 1 1 2 2 2 2 Subtilase family PA PF02225.22 ORX64684.1 - 4.7e-18 65.0 0.7 1.4e-17 63.5 0.7 1.7 1 0 0 1 1 1 1 PA domain fn3_5 PF06280.12 ORX64684.1 - 0.0013 19.4 0.1 0.016 15.9 0.0 2.8 4 0 0 4 4 4 1 Fn3-like domain CarboxypepD_reg PF13620.6 ORX64684.1 - 0.091 13.0 0.0 0.7 10.2 0.0 2.6 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Aminotran_1_2 PF00155.21 ORX64693.1 - 0.00052 19.3 0.0 0.0006 19.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_M28 PF04389.17 ORX64696.1 - 3.8e-12 46.3 0.0 5.9e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX64696.1 - 0.0083 16.1 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX64696.1 - 0.02 14.6 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Peptidase family M20/M25/M40 eIF-3_zeta PF05091.12 ORX64710.1 - 0.006 15.6 4.6 0.0083 15.2 4.6 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 ORX64710.1 - 0.043 12.6 9.5 0.078 11.7 9.5 1.4 1 0 0 1 1 1 0 Presenilin EPL1 PF10513.9 ORX64710.1 - 0.055 13.9 10.5 0.019 15.3 7.5 1.8 2 0 0 2 2 2 0 Enhancer of polycomb-like Med19 PF10278.9 ORX64710.1 - 0.066 13.1 4.9 0.13 12.2 4.9 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Spt20 PF12090.8 ORX64710.1 - 0.089 12.4 28.8 0.2 11.2 28.8 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 ORX64710.1 - 0.14 12.1 37.8 0.026 14.5 27.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 ORX64710.1 - 0.22 11.6 6.9 0.12 12.5 2.6 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 ORX64710.1 - 0.31 9.9 2.0 0.52 9.2 2.0 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 ORX64710.1 - 0.75 8.7 8.1 1.3 8.0 8.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Connexin PF00029.19 ORX64710.1 - 0.92 9.2 9.3 1.1 9.0 6.8 2.0 2 0 0 2 2 2 0 Connexin V_ATPase_I PF01496.19 ORX64710.1 - 0.98 7.3 11.0 1.4 6.8 11.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spore_coat_CotO PF14153.6 ORX64710.1 - 0.99 9.3 20.6 16 5.4 18.0 2.4 2 0 0 2 2 2 0 Spore coat protein CotO HABP4_PAI-RBP1 PF04774.15 ORX64710.1 - 1.1 10.2 13.7 2.4 9.0 13.7 1.6 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family CSG2 PF16965.5 ORX64710.1 - 2.4 7.0 5.3 3.9 6.3 5.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 ORX64710.1 - 2.5 7.1 7.5 4.5 6.2 7.5 1.3 1 0 0 1 1 1 0 CLN3 protein DUF2418 PF10332.9 ORX64710.1 - 3.6 8.2 6.0 14 6.3 3.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2418) Tim54 PF11711.8 ORX64710.1 - 4.6 5.9 14.0 8.9 5.0 14.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM176 PF14851.6 ORX64710.1 - 5 6.8 10.2 12 5.6 10.2 1.6 1 0 0 1 1 1 0 FAM176 family DUF853 PF05872.12 ORX64710.1 - 5.4 5.5 7.4 7.9 4.9 7.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Peptidase_S49_N PF08496.10 ORX64710.1 - 5.6 7.0 7.8 11 6.1 7.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SelP_N PF04592.14 ORX64710.1 - 7.9 5.8 27.3 0.021 14.2 16.4 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Sad1_UNC PF07738.13 ORX64722.1 - 2.3e-05 24.4 0.0 4.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal PBP PF01161.20 ORX64723.1 - 3.5e-15 56.5 0.0 6.8e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein N6_Mtase PF02384.16 ORX64723.1 - 0.13 11.6 0.6 0.28 10.4 0.0 1.7 2 0 0 2 2 2 0 N-6 DNA Methylase CDP-OH_P_transf PF01066.21 ORX64724.1 - 9.4e-10 39.1 0.0 9.4e-10 39.1 0.0 3.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase COesterase PF00135.28 ORX64735.1 - 0.00094 18.2 0.0 0.0012 17.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family FeoA PF04023.14 ORX64736.1 - 0.19 12.0 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 FeoA domain Phage_int_SAM_4 PF13495.6 ORX64737.1 - 0.13 12.8 0.0 0.36 11.3 0.0 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain DUF3619 PF12279.8 ORX64739.1 - 1.3 9.3 4.4 2 8.7 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Ubie_methyltran PF01209.18 ORX64752.1 - 9.2e-33 113.5 0.0 1.1e-32 113.2 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ORX64752.1 - 1.6e-15 57.6 0.1 2.6e-15 56.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX64752.1 - 4.2e-15 56.2 0.0 6.9e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX64752.1 - 4.1e-12 46.1 0.0 5.8e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX64752.1 - 2.7e-08 34.5 0.0 3.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX64752.1 - 8.2e-07 29.0 0.0 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX64752.1 - 0.0022 17.9 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Spermine_synth PF01564.17 ORX64752.1 - 0.006 16.0 0.0 0.0092 15.4 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_5 PF01795.19 ORX64752.1 - 0.097 12.2 0.0 5 6.5 0.0 2.1 1 1 1 2 2 2 0 MraW methylase family MTS PF05175.14 ORX64752.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Inhibitor_I78 PF11720.8 ORX64752.1 - 0.16 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I78 family TIP120 PF08623.10 ORX64759.1 - 1.2e-26 93.5 5.5 3.1e-22 79.1 1.3 4.7 3 1 1 4 4 4 2 TATA-binding protein interacting (TIP20) HEAT PF02985.22 ORX64759.1 - 0.0021 18.2 1.1 15 6.2 0.0 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ORX64759.1 - 0.017 15.6 6.1 0.43 11.1 0.1 5.2 5 1 1 6 6 6 0 HEAT-like repeat Homeodomain PF00046.29 ORX64761.1 - 3.8e-17 61.9 3.4 5.8e-17 61.3 3.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX64761.1 - 0.0082 16.0 0.5 0.0082 16.0 0.5 1.7 2 0 0 2 2 2 1 Homeobox KN domain Pkinase_fungal PF17667.1 ORX64769.1 - 9.9e-40 136.6 2.1 1e-30 106.9 0.0 2.9 2 1 1 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX64769.1 - 5.1e-07 29.3 0.0 5.3e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 ORX64769.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ORX64769.1 - 0.045 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX64769.1 - 0.11 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arg_repressor PF01316.21 ORX64770.1 - 0.014 15.1 0.3 0.039 13.7 0.0 1.8 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain Elongin_A PF06881.11 ORX64772.1 - 0.012 16.1 0.8 0.016 15.7 0.8 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A 2OG-Fe_Oxy_2 PF10014.9 ORX64772.1 - 0.063 13.1 0.3 0.079 12.8 0.3 1.1 1 0 0 1 1 1 0 2OG-Fe dioxygenase DUF4407 PF14362.6 ORX64772.1 - 0.11 11.9 0.7 0.12 11.7 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CBM_5_12 PF02839.14 ORX64782.1 - 0.92 10.2 12.8 67 4.4 0.1 5.6 3 2 3 6 6 6 0 Carbohydrate binding domain Myco_19_kDa PF05481.12 ORX64782.1 - 1.4 9.2 7.0 2.2 8.6 3.4 2.4 1 1 1 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen Methyltransf_16 PF10294.9 ORX64784.1 - 1.7e-10 40.9 0.1 1.4e-08 34.6 0.0 2.3 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 ORX64784.1 - 0.023 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ORX64784.1 - 0.04 13.6 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PBP1_TM PF14812.6 ORX64785.1 - 0.0083 16.5 2.8 0.016 15.5 2.8 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Aa_trans PF01490.18 ORX64786.1 - 7.2e-52 176.5 29.6 8.6e-52 176.2 29.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Metallopep PF12044.8 ORX64786.1 - 8.3e-06 24.7 0.1 1.1e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family ELFV_dehydrog PF00208.21 ORX64790.1 - 2.6e-82 276.2 1.6 3.2e-82 275.9 1.6 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ORX64790.1 - 3.1e-48 162.9 0.0 7.2e-48 161.7 0.0 1.7 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain SAM_LFY PF01698.16 ORX64790.1 - 0.0029 17.5 0.0 0.0099 15.8 0.0 1.9 2 0 0 2 2 2 1 Floricaula / Leafy protein SAM domain NAD_binding_7 PF13241.6 ORX64790.1 - 0.01 16.2 0.0 0.026 15.0 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Ribosomal_L5e PF17144.4 ORX64791.1 - 2.3e-84 281.3 0.2 3.9e-84 280.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ORX64791.1 - 4e-34 117.4 1.7 4e-34 117.4 1.7 1.9 2 1 0 2 2 2 1 Ribosomal L18 C-terminal region Hexapep_2 PF14602.6 ORX64792.1 - 0.22 11.3 7.9 17 5.2 0.0 4.5 2 2 3 5 5 5 0 Hexapeptide repeat of succinyl-transferase Pam16 PF03656.13 ORX64794.1 - 1.1e-30 106.3 2.7 1.1e-30 106.2 2.7 1.0 1 0 0 1 1 1 1 Pam16 Sec3_C PF09763.9 ORX64795.1 - 3.8e-119 399.1 2.0 4.7e-119 398.8 2.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 COG6 PF06419.11 ORX64795.1 - 5e-06 25.0 11.7 0.0056 15.0 2.7 2.3 2 0 0 2 2 2 2 Conserved oligomeric complex COG6 Sec3_C_2 PF15278.6 ORX64795.1 - 0.38 11.1 4.3 2.5 8.5 0.1 3.7 4 0 0 4 4 4 0 Sec3 exocyst complex subunit WAC_Acf1_DNA_bd PF10537.9 ORX64795.1 - 0.65 10.5 2.8 1.2 9.7 0.2 2.9 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal YabA PF06156.13 ORX64795.1 - 5.9 7.6 11.6 0.56 10.9 3.6 3.1 3 0 0 3 3 3 0 Initiation control protein YabA Cys_rich_KTR PF14205.6 ORX64797.1 - 0.024 14.4 0.3 0.029 14.2 0.3 1.2 1 0 0 1 1 1 0 Cysteine-rich KTR PT-VENN PF04829.13 ORX64797.1 - 0.59 10.3 9.2 0.84 9.8 9.2 1.2 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif AF-4 PF05110.13 ORX64800.1 - 5.6 4.9 14.5 0.062 11.4 6.6 1.6 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Carn_acyltransf PF00755.20 ORX64801.1 - 3.6e-16 58.9 0.4 1.1e-09 37.5 0.1 2.0 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase AAA_lid_3 PF17862.1 ORX64807.1 - 0.28 11.0 0.6 79 3.2 0.1 2.9 3 0 0 3 3 3 0 AAA+ lid domain Metallothio_PEC PF02068.16 ORX64807.1 - 0.91 9.9 12.7 0.42 11.0 6.3 2.0 1 1 1 2 2 2 0 Plant PEC family metallothionein Lactococcin PF04369.13 ORX64807.1 - 4 7.6 4.9 1.1e+02 3.0 0.1 3.0 2 1 1 3 3 3 0 Lactococcin-like family Abhydrolase_1 PF00561.20 ORX64808.1 - 1.6e-09 37.8 0.0 2.5e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX64808.1 - 3.8e-05 24.4 0.6 7.4e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX64808.1 - 0.00012 21.4 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Glyco_hydro_61 PF03443.14 ORX64809.1 - 1.6e-20 74.0 0.9 4.4e-20 72.5 0.9 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 QRPTase_N PF02749.16 ORX64809.1 - 0.15 12.2 0.0 1.8 8.6 0.0 2.2 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain DUF4545 PF15078.6 ORX64810.1 - 0.027 13.5 2.1 0.046 12.7 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4545) ZFYVE21_C PF16696.5 ORX64810.1 - 0.039 13.8 1.1 0.089 12.7 1.1 1.6 1 0 0 1 1 1 0 Zinc finger FYVE domain-containing protein 21 C-terminus SYF2 PF08231.12 ORX64810.1 - 0.36 11.2 9.2 0.083 13.3 5.5 1.7 2 0 0 2 2 2 0 SYF2 splicing factor DUF4406 PF14359.6 ORX64823.1 - 0.51 10.9 10.3 1.7e+02 2.8 0.1 6.3 1 1 7 8 8 8 0 Domain of unknown function (DUF4406) SNF2_N PF00176.23 ORX64825.1 - 4e-25 88.3 0.0 4.8e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain SWI2_SNF2 PF18766.1 ORX64825.1 - 0.25 11.0 0.0 0.42 10.2 0.0 1.3 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Thioredoxin PF00085.20 ORX64837.1 - 3.5e-27 94.4 0.0 4.3e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX64837.1 - 2.4e-08 34.4 0.2 2.4e-06 28.0 0.2 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ORX64837.1 - 5.7e-06 26.1 0.0 7e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ORX64837.1 - 3.5e-05 24.1 0.0 0.00072 19.8 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ORX64837.1 - 0.00029 20.8 0.0 0.00042 20.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 ORX64837.1 - 0.0055 16.9 0.1 0.0096 16.1 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 ORX64837.1 - 0.031 14.1 0.0 0.043 13.6 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_5 PF13743.6 ORX64837.1 - 0.062 13.0 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 ORX64837.1 - 0.076 13.4 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) p450 PF00067.22 ORX64855.1 - 1.3e-63 215.4 0.0 1.7e-63 215.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M36 PF02128.15 ORX64893.1 - 3e-154 513.6 3.2 4e-154 513.2 3.2 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX64893.1 - 1.1e-12 47.6 2.7 1.1e-12 47.6 2.7 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX64893.1 - 1.1e-05 25.4 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX64893.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Peptidase_M36 PF02128.15 ORX64894.1 - 3e-154 513.7 3.2 4e-154 513.2 3.2 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX64894.1 - 1.1e-12 47.6 2.7 1.1e-12 47.6 2.7 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX64894.1 - 1.1e-05 25.4 0.0 2.5e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX64894.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Vps16_N PF04841.13 ORX64918.1 - 1.9e-42 145.5 0.0 5.1e-33 114.4 0.0 2.1 2 0 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.12 ORX64918.1 - 1.5e-36 126.0 0.0 7.1e-35 120.6 0.0 2.3 1 1 0 2 2 2 1 Vps16, C-terminal region NHL PF01436.21 ORX64918.1 - 0.013 15.5 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 NHL repeat F-box-like PF12937.7 ORX64919.1 - 0.033 14.1 0.2 0.091 12.7 0.2 1.8 1 0 0 1 1 1 0 F-box-like Cbl_N3 PF02762.14 ORX64920.1 - 2e-05 24.4 15.2 34 4.4 0.0 9.1 1 1 9 11 11 11 1 CBL proto-oncogene N-terminus, SH2-like domain DUF3725 PF12523.8 ORX64920.1 - 0.0037 17.5 1.5 1.4e+02 2.9 0.0 6.5 4 3 3 8 8 8 0 Protein of unknown function (DUF3725) CE2_N PF17996.1 ORX64920.1 - 0.005 16.8 27.8 2.6 8.1 1.1 6.0 1 1 5 6 6 6 5 Carbohydrate esterase 2 N-terminal Pentapeptide_3 PF13576.6 ORX64920.1 - 0.029 14.5 6.5 56 4.0 0.1 6.2 4 3 2 6 6 6 0 Pentapeptide repeats (9 copies) DUF4781 PF16013.5 ORX64920.1 - 0.81 8.4 47.4 4.9 5.9 3.8 7.0 1 1 5 6 6 6 0 Domain of unknown function (DUF4781) Ribonuclease_T2 PF00445.18 ORX64921.1 - 7.8e-37 127.3 0.2 1.2e-36 126.7 0.2 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Apt1 PF10351.9 ORX64921.1 - 1.8 7.3 3.8 2.1 7.1 3.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GDPD PF03009.17 ORX64922.1 - 2.9e-29 102.6 0.0 1.2e-28 100.5 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Pkinase_fungal PF17667.1 ORX64931.1 - 3.5e-78 263.2 0.6 2.2e-28 99.2 0.0 3.6 3 1 0 4 4 4 3 Fungal protein kinase Pkinase PF00069.25 ORX64931.1 - 5.1e-09 35.9 0.0 0.00018 21.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 ORX64931.1 - 2.3e-06 27.3 0.0 0.079 12.5 0.0 2.5 2 0 0 2 2 2 2 RIO1 family APH PF01636.23 ORX64931.1 - 0.00027 21.0 2.0 0.17 11.8 0.2 2.9 3 1 0 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX64931.1 - 0.002 17.5 0.2 2.2 7.6 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 ORX64931.1 - 0.002 17.4 0.2 1.7 7.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase FhuF PF06276.12 ORX64931.1 - 0.0033 17.9 0.0 3.8 7.9 0.0 2.6 2 0 0 2 2 2 2 Ferric iron reductase FhuF-like transporter LSM PF01423.22 ORX64931.1 - 0.12 12.1 0.1 16 5.3 0.0 2.6 2 0 0 2 2 2 0 LSM domain YrbL-PhoP_reg PF10707.9 ORX64931.1 - 0.15 11.6 0.0 22 4.5 0.0 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Arg_repressor PF01316.21 ORX64932.1 - 0.034 13.9 0.3 0.077 12.8 0.0 1.7 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain RRM_1 PF00076.22 ORX64933.1 - 1.4e-15 56.8 0.0 2e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX64933.1 - 6.5e-09 36.2 13.0 6.5e-09 36.2 13.0 1.7 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 DAGAT PF03982.13 ORX64956.1 - 2.2e-68 230.4 0.0 2.5e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase VirB3 PF05101.13 ORX64956.1 - 0.75 10.1 3.5 34 4.8 0.0 3.2 3 1 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein Vezatin PF12632.7 ORX64957.1 - 2e-11 43.8 0.6 1.7e-10 40.8 0.6 2.1 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes SLATT_1 PF18181.1 ORX64957.1 - 0.033 14.1 0.6 0.09 12.7 0.6 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Cg6151-P PF10233.9 ORX64962.1 - 8.5e-23 80.8 10.2 9.8e-23 80.6 10.2 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Goodbye PF17109.5 ORX64962.1 - 0.4 11.1 3.6 1.5 9.3 0.4 2.1 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain PTPS_related PF10131.9 ORX64962.1 - 0.9 7.8 5.9 1.1 7.6 5.9 1.0 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF3817 PF12823.7 ORX64962.1 - 3 8.7 11.3 33 5.4 11.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3817) Orthoreo_P10 PF07204.11 ORX64962.1 - 9.6 6.2 8.0 0.19 11.7 0.7 1.9 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 HC2 PF07382.11 ORX64963.1 - 2e-08 34.6 0.5 2.4e-08 34.3 0.5 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.11 ORX64963.1 - 0.064 13.0 12.5 0.12 12.2 2.3 2.4 1 1 1 2 2 2 0 African swine fever virus J13L protein VCX_VCY PF15231.6 ORX64963.1 - 0.46 11.2 28.5 0.079 13.7 14.0 2.5 1 1 1 2 2 2 0 Variable charge X/Y family HC2 PF07382.11 ORX64964.1 - 5.4e-17 62.5 4.1 2.9e-06 27.5 0.1 5.1 2 1 3 5 5 5 4 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.11 ORX64964.1 - 0.00039 20.2 37.0 2.2 8.0 1.5 8.7 3 3 5 8 8 8 6 African swine fever virus J13L protein Ribosomal_L33 PF00471.20 ORX64979.1 - 6.2e-10 39.4 0.0 9.1e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 OxoGdeHyase_C PF16870.5 ORX65014.1 - 3.7e-39 133.9 0.0 4.4e-39 133.6 0.0 1.0 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal MutS_V PF00488.21 ORX65022.1 - 1.5e-68 230.6 0.0 1.8e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 MutS domain V Tyr-DNA_phospho PF06087.12 ORX65025.1 - 1.8e-55 188.6 0.3 2.3e-55 188.2 0.3 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 ORX65025.1 - 6.3e-06 26.1 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain DALR_1 PF05746.15 ORX65026.1 - 3.8 7.7 5.9 17 5.7 3.5 2.7 2 1 0 2 2 2 0 DALR anticodon binding domain Sugar_tr PF00083.24 ORX65027.1 - 1.5e-43 149.4 36.2 1.4e-29 103.3 15.9 3.7 2 2 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX65027.1 - 1.6e-08 33.9 8.9 1.6e-08 33.9 8.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily RNA_pol_3_Rpc31 PF11705.8 ORX65048.1 - 0.037 14.3 4.4 0.05 13.8 4.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.5 ORX65048.1 - 0.39 10.1 9.0 0.51 9.7 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIF_alpha PF05793.12 ORX65048.1 - 0.57 8.7 8.8 0.74 8.3 8.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1729 PF08354.10 ORX65063.1 - 2.4e-126 421.4 0.0 3.7e-126 420.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX65063.1 - 2.1e-47 161.5 0.0 4.3e-47 160.5 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX65063.1 - 3.8e-37 128.5 0.0 1.3e-35 123.5 0.0 3.2 2 1 0 2 2 2 1 Acyl transferase domain FAS_I_H PF18314.1 ORX65063.1 - 3.7e-34 118.1 0.0 8e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain FAS_meander PF17951.1 ORX65063.1 - 1.4e-21 76.8 0.0 3.7e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX65063.1 - 6e-21 75.2 0.2 1.4e-20 74.0 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ORX65063.1 - 2.4e-20 72.3 0.1 5.7e-20 71.1 0.1 1.6 1 0 0 1 1 1 1 MaoC like domain Ketoacyl-synt_C PF02801.22 ORX65063.1 - 1.3e-13 50.9 0.0 3.8e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SAT PF16073.5 ORX65063.1 - 3.6e-12 46.5 0.0 8.4e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 ORX65063.1 - 1.4e-05 25.3 0.0 3.9e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX65063.1 - 0.00014 21.9 0.0 0.00054 20.0 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta adh_short_C2 PF13561.6 ORX65064.1 - 1.8e-48 165.2 0.0 2.2e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX65064.1 - 6.2e-43 146.5 0.0 1.1e-42 145.7 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ORX65064.1 - 1.8e-10 41.0 0.0 3.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX65064.1 - 0.0012 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 ORX65064.1 - 0.017 14.2 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 ORX65064.1 - 0.035 13.6 0.0 1.2 8.5 0.0 2.1 1 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Methyltransf_PK PF05891.12 ORX65064.1 - 0.067 12.7 0.0 0.63 9.5 0.0 2.1 1 1 1 2 2 2 0 AdoMet dependent proline di-methyltransferase 3Beta_HSD PF01073.19 ORX65064.1 - 0.08 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_7 PF13241.6 ORX65064.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding GDP_Man_Dehyd PF16363.5 ORX65064.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fas_alpha_ACP PF18325.1 ORX65080.1 - 4.9e-50 170.0 0.1 7.3e-50 169.5 0.1 1.3 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX65080.1 - 0.00014 21.4 0.0 0.0022 17.5 0.0 2.4 2 0 0 2 2 2 1 Acyl transferase domain Band_7 PF01145.25 ORX65080.1 - 0.15 12.0 0.0 0.43 10.6 0.0 1.8 2 0 0 2 2 2 0 SPFH domain / Band 7 family ketoacyl-synt PF00109.26 ORX65081.1 - 8.6e-17 61.5 0.4 1.7e-16 60.6 0.4 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX65081.1 - 9.4e-12 45.0 0.0 2.8e-11 43.4 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 ORX65081.1 - 5e-07 29.4 0.0 2.2e-06 27.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase Remorin_C PF03763.13 ORX65081.1 - 0.0044 16.9 1.1 0.0044 16.9 1.1 2.1 2 0 0 2 2 2 1 Remorin, C-terminal region GDP_Man_Dehyd PF16363.5 ORX65081.1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Glyco_hydro_46 PF01374.18 ORX65082.1 - 2.8e-45 154.5 3.2 1e-44 152.7 3.2 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 Ccdc124 PF06244.12 ORX65083.1 - 4.1e-30 105.0 16.8 4.1e-30 105.0 16.8 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 ORX65083.1 - 0.0042 17.5 0.1 0.0042 17.5 0.1 2.5 2 1 0 2 2 2 1 HMG (high mobility group) box YABBY PF04690.13 ORX65083.1 - 0.52 10.9 8.6 8.6 6.9 7.9 2.4 1 1 0 1 1 1 0 YABBY protein MAD PF05557.13 ORX65084.1 - 4e-19 68.5 70.1 5e-13 48.3 5.6 3.8 2 1 0 2 2 2 2 Mitotic checkpoint protein HALZ PF02183.18 ORX65084.1 - 0.046 14.0 32.9 0.15 12.3 0.1 7.9 6 1 2 8 8 8 0 Homeobox associated leucine zipper NPV_P10 PF05531.12 ORX65084.1 - 0.11 12.9 15.1 1.7 9.1 1.1 4.5 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF5481 PF17578.2 ORX65084.1 - 0.13 12.7 1.2 0.61 10.5 0.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5481) RBD-FIP PF09457.10 ORX65084.1 - 0.16 11.9 4.7 0.085 12.8 0.4 3.0 2 0 0 2 2 2 0 FIP domain TetR_C_13 PF16925.5 ORX65084.1 - 4.3 7.3 10.1 0.46 10.4 2.1 3.2 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain CSN8_PSD8_EIF3K PF10075.9 ORX65085.1 - 6.2e-21 74.9 0.0 1.1e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Hexapep PF00132.24 ORX65086.1 - 4.6e-07 29.3 12.2 0.0039 16.9 2.4 5.2 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ORX65086.1 - 0.0052 16.5 12.8 0.061 13.1 2.4 3.9 3 1 2 5 5 5 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ORX65086.1 - 0.045 12.7 0.0 0.066 12.2 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase DUF2534 PF10749.9 ORX65087.1 - 6 7.1 7.3 1 9.6 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) PIG-S PF10510.9 ORX65089.1 - 1.2e-113 380.7 0.8 1.6e-99 334.1 0.1 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein HicB_lk_antitox PF15919.5 ORX65089.1 - 0.074 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system DUF2252 PF10009.9 ORX65089.1 - 0.11 11.6 0.3 0.2 10.7 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) AAA_33 PF13671.6 ORX65090.1 - 2e-19 70.1 0.1 4.4e-11 43.1 0.1 2.0 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 ORX65090.1 - 2.6e-05 24.8 0.2 0.014 15.9 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX65090.1 - 7.3e-05 23.1 0.0 9.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 ORX65090.1 - 7.5e-05 22.9 0.0 9.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_17 PF13207.6 ORX65090.1 - 9.1e-05 22.9 0.8 0.17 12.3 0.1 2.1 1 1 1 2 2 2 2 AAA domain AAA_28 PF13521.6 ORX65090.1 - 0.00013 22.2 0.0 0.00017 21.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX65090.1 - 0.00085 19.8 0.0 0.0009 19.7 0.0 1.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 ORX65090.1 - 0.0028 17.2 0.2 0.24 10.8 0.1 2.0 1 1 1 2 2 2 1 Chromatin associated protein KTI12 AAA_5 PF07728.14 ORX65090.1 - 0.0056 16.7 0.1 0.017 15.2 0.1 1.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 ORX65090.1 - 0.0063 16.2 0.1 0.22 11.2 0.0 2.6 1 1 1 2 2 2 1 Thymidylate kinase NACHT PF05729.12 ORX65090.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ORX65090.1 - 0.016 15.6 0.0 0.022 15.1 0.0 1.2 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 ORX65090.1 - 0.019 15.3 0.0 0.02 15.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ORX65090.1 - 0.041 13.3 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ORX65090.1 - 0.059 12.6 0.1 0.52 9.5 0.0 2.0 1 1 1 2 2 2 0 Zeta toxin AAA_24 PF13479.6 ORX65090.1 - 0.072 12.8 0.0 0.081 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ORX65090.1 - 0.094 12.0 0.1 0.3 10.4 0.0 1.7 1 1 1 2 2 2 0 6-phosphofructo-2-kinase Sigma54_activ_2 PF14532.6 ORX65090.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain SKI PF01202.22 ORX65090.1 - 0.12 12.5 0.0 4.2 7.5 0.1 2.2 1 1 0 2 2 2 0 Shikimate kinase dNK PF01712.19 ORX65090.1 - 0.18 11.6 0.0 17 5.2 0.0 2.6 1 1 2 3 3 3 0 Deoxynucleoside kinase Malic_M PF03949.15 ORX65091.1 - 1.4e-79 267.0 0.0 2.2e-79 266.4 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX65091.1 - 9.9e-60 201.4 0.0 1.6e-59 200.8 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain MFS_1 PF07690.16 ORX65092.1 - 3.1e-27 95.4 61.1 2.4e-24 85.9 40.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3290 PF11694.8 ORX65092.1 - 0.02 14.9 0.3 3 7.8 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) POT1 PF02765.17 ORX65093.1 - 1.5e-09 37.8 0.0 2.8e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.5 ORX65093.1 - 7.8e-06 25.8 0.0 0.0013 18.7 0.1 2.7 2 1 0 2 2 2 1 ssDNA-binding domain of telomere protection protein PRR18 PF15671.5 ORX65093.1 - 0.014 15.2 0.9 0.03 14.2 0.9 1.5 1 0 0 1 1 1 0 Proline-rich protein family 18 Clat_adaptor_s PF01217.20 ORX65094.1 - 2.1e-53 180.1 3.9 3.6e-53 179.3 3.9 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Peptidase_M20 PF01546.28 ORX65094.1 - 5e-25 88.4 0.0 9.4e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 ORX65094.1 - 9e-11 42.2 17.7 0.0026 18.6 0.5 6.9 6 0 0 6 6 6 5 WD domain, G-beta repeat M20_dimer PF07687.14 ORX65094.1 - 3.9e-10 39.6 0.0 8.5e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 ORX65094.1 - 0.00021 21.5 0.2 2 8.8 0.0 5.0 3 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX65094.1 - 0.00062 19.2 0.0 0.96 8.7 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain PQQ_3 PF13570.6 ORX65094.1 - 0.026 15.0 10.8 16 6.1 0.1 5.7 6 0 0 6 6 6 0 PQQ-like domain AAA PF00004.29 ORX65095.1 - 1.7e-83 277.7 0.0 3.9e-42 143.8 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX65095.1 - 5.7e-34 115.7 2.3 2e-16 59.5 0.2 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX65095.1 - 2.6e-13 50.7 0.2 2.1e-06 28.2 0.2 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 ORX65095.1 - 3.2e-13 49.9 0.3 2.1e-06 27.8 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX65095.1 - 1.5e-12 48.0 0.0 1.1e-05 25.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX65095.1 - 2.1e-12 47.1 0.5 4.4e-05 23.3 0.1 3.2 2 2 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX65095.1 - 1.2e-08 35.3 2.3 0.0056 16.9 0.3 4.3 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX65095.1 - 2e-07 31.1 0.0 0.028 14.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ORX65095.1 - 2.8e-07 30.8 0.3 0.047 13.9 0.0 3.1 3 1 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 ORX65095.1 - 6.1e-07 29.8 0.0 0.023 15.1 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 ORX65095.1 - 1.5e-06 28.3 0.0 0.00032 20.7 0.0 2.6 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_3 PF07726.11 ORX65095.1 - 2.7e-06 27.3 1.2 0.0062 16.4 0.0 3.0 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ORX65095.1 - 2.8e-06 27.4 0.0 0.11 12.4 0.0 3.3 2 2 0 3 3 3 2 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ORX65095.1 - 8.4e-06 26.3 0.0 0.13 12.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Viral_helicase1 PF01443.18 ORX65095.1 - 1.4e-05 25.0 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.18 ORX65095.1 - 1.6e-05 24.8 0.0 0.0014 18.5 0.0 2.9 2 2 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.12 ORX65095.1 - 2.3e-05 24.4 0.1 0.059 13.3 0.0 3.2 2 1 1 3 3 3 1 NACHT domain TIP49 PF06068.13 ORX65095.1 - 5.8e-05 22.5 0.0 0.091 11.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain TsaE PF02367.17 ORX65095.1 - 7.2e-05 22.8 0.0 0.073 13.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ORX65095.1 - 9.4e-05 22.2 0.0 0.0045 16.7 0.0 2.7 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_24 PF13479.6 ORX65095.1 - 0.00013 21.8 0.0 0.044 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ORX65095.1 - 0.00013 21.6 1.1 0.46 10.0 0.1 3.8 2 2 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX65095.1 - 0.00017 21.5 1.2 0.67 9.9 0.1 3.0 2 2 1 3 3 3 2 NTPase AAA_7 PF12775.7 ORX65095.1 - 0.00018 21.1 0.1 0.23 11.0 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_11 PF13086.6 ORX65095.1 - 0.00018 21.4 0.1 0.26 11.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 ORX65095.1 - 0.0002 21.3 0.0 0.07 13.1 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 ORX65095.1 - 0.00041 19.6 0.0 0.33 10.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 ORX65095.1 - 0.00074 19.0 0.3 1.5 8.2 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.14 ORX65095.1 - 0.00089 18.6 0.0 2.5 7.2 0.0 3.1 3 1 0 3 3 3 2 KAP family P-loop domain AFG1_ATPase PF03969.16 ORX65095.1 - 0.0011 18.0 0.0 0.074 11.9 0.0 2.5 2 0 0 2 2 2 1 AFG1-like ATPase AAA_28 PF13521.6 ORX65095.1 - 0.0022 18.3 0.6 0.97 9.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX65095.1 - 0.003 18.1 0.0 0.22 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX65095.1 - 0.0048 17.2 2.5 0.66 10.3 0.2 3.1 2 2 1 3 3 3 1 AAA domain AAA_30 PF13604.6 ORX65095.1 - 0.0054 16.5 0.1 1.1 8.9 0.1 3.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX65095.1 - 0.0063 15.8 0.0 0.63 9.3 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.6 ORX65095.1 - 0.0083 16.6 0.7 5.7 7.4 0.1 3.0 2 1 0 2 2 2 0 AAA domain MCM PF00493.23 ORX65095.1 - 0.01 14.9 0.0 3.7 6.6 0.0 2.5 2 1 0 2 2 2 0 MCM P-loop domain NB-ARC PF00931.22 ORX65095.1 - 0.011 14.9 0.0 1.8 7.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.26 ORX65095.1 - 0.018 14.8 0.3 12 5.5 0.0 3.9 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 ORX65095.1 - 0.036 13.8 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 ORX65095.1 - 0.045 13.2 0.1 4.6 6.6 0.0 3.4 3 1 1 4 4 4 0 Bacterial TniB protein RsgA_GTPase PF03193.16 ORX65095.1 - 0.058 13.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 ORX65095.1 - 0.21 11.8 0.4 6.2 7.1 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 ORX65096.1 - 4.6e-67 220.3 21.9 8.5e-11 42.2 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65096.1 - 2.9e-27 94.8 1.1 6.7e-06 26.3 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX65096.1 - 4.3e-16 58.7 6.6 0.0025 16.6 0.0 5.0 3 1 3 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX65096.1 - 2.2e-11 44.0 0.2 0.00016 21.7 0.0 4.0 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX65096.1 - 2.1e-08 33.5 4.1 0.24 10.3 0.0 4.8 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX65096.1 - 4.7e-07 29.4 0.0 9.5e-05 21.9 0.0 2.9 1 1 3 4 4 4 2 WD40-like domain RicinB_lectin_2 PF14200.6 ORX65096.1 - 6.9e-07 29.9 3.8 0.0064 17.2 0.1 3.1 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like PALB2_WD40 PF16756.5 ORX65096.1 - 1.6e-06 27.3 5.8 0.043 12.7 0.0 4.9 1 1 4 5 5 5 3 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ORX65096.1 - 9.3e-05 21.9 0.8 2.8 7.2 0.0 4.0 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Ricin_B_lectin PF00652.22 ORX65096.1 - 0.0002 21.6 2.2 0.012 15.9 0.1 3.0 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 ORX65096.1 - 0.00077 19.1 0.5 0.24 11.0 0.0 3.0 1 1 2 3 3 3 1 Cytolethal distending toxin A/C domain Frtz PF11768.8 ORX65096.1 - 0.002 16.5 0.1 0.017 13.5 0.0 2.1 1 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF1513 PF07433.11 ORX65096.1 - 0.022 13.9 0.2 12 4.8 0.0 3.5 1 1 1 4 4 4 0 Protein of unknown function (DUF1513) IKI3 PF04762.12 ORX65096.1 - 0.022 12.8 0.2 0.069 11.1 0.1 1.7 1 1 0 1 1 1 0 IKI3 family Cytochrom_D1 PF02239.16 ORX65096.1 - 0.033 12.7 0.0 1.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 ORX65096.1 - 0.12 12.4 2.1 4 7.5 0.1 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Hira PF07569.11 ORX65096.1 - 0.2 11.4 4.2 23 4.6 0.0 4.1 2 1 3 5 5 5 0 TUP1-like enhancer of split Y_phosphatase2 PF03162.13 ORX65097.1 - 2.3e-49 167.2 0.0 2.6e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX65097.1 - 3.1e-05 24.1 0.0 3.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX65097.1 - 0.0021 17.9 0.0 0.0032 17.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX65097.1 - 0.032 13.8 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ATP-synt_J PF04911.12 ORX65098.1 - 0.005 16.4 0.2 0.017 14.7 0.2 1.8 1 1 0 1 1 1 1 ATP synthase j chain ApbA PF02558.16 ORX65105.1 - 1.4e-26 93.0 0.0 2.2e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX65105.1 - 9.9e-25 87.2 0.0 1.6e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ThiF PF00899.21 ORX65105.1 - 0.069 12.5 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 ThiF family ApbA PF02558.16 ORX65106.1 - 4.5e-27 94.6 0.0 7.6e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX65106.1 - 4.1e-15 56.1 0.1 8.4e-15 55.1 0.1 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal GFO_IDH_MocA PF01408.22 ORX65106.1 - 0.066 14.0 0.0 0.17 12.7 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold DUF3255 PF11631.8 ORX65106.1 - 0.095 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3255) GARS_N PF02844.15 ORX65106.1 - 0.097 13.5 0.0 0.22 12.3 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain ThiF PF00899.21 ORX65106.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 ThiF family PglD_N PF17836.1 ORX65106.1 - 0.15 12.7 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 PglD N-terminal domain BAR PF03114.18 ORX65118.1 - 0.005 16.5 0.0 0.0052 16.4 0.0 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 ORX65118.1 - 0.041 13.0 0.0 0.043 12.9 0.0 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_2 PF10455.9 ORX65119.1 - 7.9e-11 41.6 4.5 5.4e-06 25.8 1.5 2.5 1 1 1 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 ORX65119.1 - 9.7e-05 22.1 3.8 0.00013 21.7 3.8 1.2 1 0 0 1 1 1 1 BAR domain TBCC_N PF16752.5 ORX65119.1 - 0.016 15.6 1.0 0.016 15.6 1.0 1.9 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Rsd_AlgQ PF04353.13 ORX65119.1 - 0.067 13.1 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ JAKMIP_CC3 PF16034.5 ORX65119.1 - 0.51 10.2 6.2 0.21 11.5 1.7 2.1 1 1 1 2 2 2 0 JAKMIP CC3 domain HAD_2 PF13419.6 ORX65120.1 - 4.5e-08 33.4 0.0 1.2e-07 32.0 0.0 1.7 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX65120.1 - 1.8e-06 27.9 0.1 2.8e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX65120.1 - 1.2e-05 25.7 0.1 1.8e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2834 PF11196.8 ORX65121.1 - 0.021 15.2 0.1 0.054 13.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2834) Lipase_3 PF01764.25 ORX65122.1 - 1.2e-34 119.2 0.0 2e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Alpha-L-AF_C PF06964.12 ORX65122.1 - 0.029 14.5 2.0 0.037 14.1 2.0 1.2 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain Phage_lysozyme PF00959.19 ORX65123.1 - 4.3e-10 40.0 0.0 6.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX65123.1 - 6.5e-08 32.7 0.2 1.6e-07 31.5 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 ORX65123.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain AdenylateSensor PF16579.5 ORX65132.1 - 9.6e-17 61.5 0.1 5.1e-13 49.5 0.3 2.9 2 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase HLH PF00010.26 ORX65134.1 - 3e-14 52.7 1.5 5.3e-14 51.9 1.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain FMN_dh PF01070.18 ORX65145.1 - 9.1e-110 366.9 0.3 2.6e-108 362.2 0.3 2.0 1 1 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ORX65145.1 - 6.8e-05 22.0 0.2 0.00014 21.0 0.2 1.6 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 ORX65145.1 - 0.002 17.3 0.2 0.0033 16.6 0.2 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 ORX65145.1 - 0.0082 15.6 0.1 0.033 13.7 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ORX65145.1 - 0.039 13.3 0.2 1 8.6 0.0 2.3 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG LRR_4 PF12799.7 ORX65146.1 - 0.0027 18.1 0.2 4 8.0 0.0 3.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) HNF-1A_C PF04813.12 ORX65146.1 - 0.11 13.3 0.2 0.22 12.3 0.2 1.4 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus GGGtGRT PF14057.6 ORX65147.1 - 0.021 13.8 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 GGGtGRT protein zf-RVT PF13966.6 ORX65160.1 - 0.002 18.8 0.0 0.006 17.3 0.0 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase IL5 PF02025.15 ORX65161.1 - 0.24 11.7 0.0 0.25 11.6 0.0 1.1 1 0 0 1 1 1 0 Interleukin 5 DNA_pol_B_thumb PF14791.6 ORX65162.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase beta thumb UPF1_Zn_bind PF09416.10 ORX65165.1 - 4.7e-66 221.5 4.5 6.6e-66 221.0 4.5 1.2 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) DUF5599 PF18141.1 ORX65165.1 - 0.03 14.6 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5599) KAR9 PF08580.10 ORX65177.1 - 0.00094 17.9 0.4 0.0012 17.5 0.4 1.1 1 0 0 1 1 1 1 Yeast cortical protein KAR9 Baculo_PEP_C PF04513.12 ORX65177.1 - 0.0023 17.9 1.9 0.0039 17.2 1.9 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.11 ORX65177.1 - 0.0092 15.3 2.7 0.0092 15.3 2.7 1.7 2 0 0 2 2 2 1 SF-assemblin/beta giardin Mer2 PF09074.10 ORX65177.1 - 0.01 15.7 2.8 0.014 15.2 1.6 1.7 2 0 0 2 2 2 0 Mer2 Vps51 PF08700.11 ORX65177.1 - 0.041 14.0 1.1 0.058 13.5 0.3 1.7 2 0 0 2 2 2 0 Vps51/Vps67 RRF PF01765.19 ORX65177.1 - 0.12 12.3 2.5 3.3 7.6 0.2 2.2 2 0 0 2 2 2 0 Ribosome recycling factor DLP_helical PF18709.1 ORX65177.1 - 0.26 10.4 4.4 0.087 12.0 1.7 1.5 2 0 0 2 2 2 0 Dynamin-like helical domain Hrs_helical PF12210.8 ORX65177.1 - 0.31 11.6 3.6 0.13 12.8 1.0 1.7 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Choline_kinase PF01633.20 ORX65179.1 - 0.042 13.4 0.1 0.064 12.8 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase GN3L_Grn1 PF08701.11 ORX65179.1 - 0.23 11.6 0.0 0.33 11.1 0.0 1.2 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase APH PF01636.23 ORX65181.1 - 1.2e-08 35.2 0.0 2.9e-06 27.4 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 ORX65181.1 - 9.5e-06 25.2 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 ORX65181.1 - 0.001 18.7 0.1 0.0024 17.5 0.0 1.6 1 1 1 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 ORX65181.1 - 0.0011 18.3 0.0 0.0011 18.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ORX65181.1 - 0.0014 18.2 0.3 0.012 15.2 0.0 2.2 1 1 2 3 3 3 1 Choline/ethanolamine kinase DUF1679 PF07914.11 ORX65181.1 - 0.0059 15.5 0.0 0.0074 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Kdo PF06293.14 ORX65181.1 - 0.015 14.7 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CAP59_mtransfer PF11735.8 ORX65182.1 - 2e-43 148.8 0.1 2.2e-43 148.7 0.1 1.0 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Pkinase PF00069.25 ORX65183.1 - 2.1e-09 37.1 0.0 2.8e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ORX65183.1 - 2.4e-06 27.7 0.0 3.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX65183.1 - 7.2e-05 22.2 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ORX65183.1 - 0.00018 20.6 0.1 0.00018 20.6 0.1 1.7 2 0 0 2 2 2 1 Seadornavirus VP7 RIO1 PF01163.22 ORX65183.1 - 0.0012 18.5 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 ORX65183.1 - 0.0041 16.7 0.0 0.0067 16.0 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ORX65183.1 - 0.0084 14.9 0.1 0.0095 14.7 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ORX65183.1 - 0.019 14.3 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase YrbL-PhoP_reg PF10707.9 ORX65183.1 - 0.021 14.3 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.6 ORX65183.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Cbl_N2 PF02761.14 ORX65184.1 - 0.031 15.0 0.1 0.47 11.2 0.1 2.6 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain DivIVA PF05103.13 ORX65184.1 - 0.16 12.1 5.7 2.2 8.4 5.7 2.3 1 1 0 1 1 1 0 DivIVA protein BAR_3 PF16746.5 ORX65184.1 - 0.18 11.5 4.1 0.12 12.1 2.2 1.6 2 0 0 2 2 2 0 BAR domain of APPL family OmpH PF03938.14 ORX65184.1 - 0.3 11.4 6.3 0.59 10.5 6.3 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Remorin_C PF03763.13 ORX65184.1 - 1.1 9.2 8.4 0.9 9.4 6.8 1.7 1 1 1 2 2 2 0 Remorin, C-terminal region HET PF06985.11 ORX65185.1 - 3.6e-17 63.1 0.2 5.3e-17 62.5 0.2 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF4581 PF15167.6 ORX65185.1 - 0.033 14.3 0.1 0.054 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4581) HSDR_N_2 PF13588.6 ORX65186.1 - 0.00019 21.4 0.0 0.00024 21.1 0.0 1.2 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) PDDEXK_3 PF13366.6 ORX65186.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily NPFF PF15085.6 ORX65186.1 - 0.16 12.4 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Neuropeptide FF RNA_pol_Rpb2_6 PF00562.28 ORX65187.1 - 1.3e-24 87.0 0.3 1.1e-22 80.7 0.3 2.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 ORX65187.1 - 4.5e-12 46.2 0.1 8.8e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF1148 PF06618.11 ORX65187.1 - 0.061 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1148) NmrA PF05368.13 ORX65187.1 - 0.099 12.2 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 NmrA-like family Coronavirus_5 PF05528.11 ORX65188.1 - 0.052 13.5 0.3 0.052 13.5 0.3 1.8 2 0 0 2 2 2 0 Coronavirus gene 5 protein Holin_BhlA PF10960.8 ORX65188.1 - 2.2 8.3 11.0 2.7 8.0 1.6 2.3 2 0 0 2 2 2 0 BhlA holin family Methyltransf_23 PF13489.6 ORX65189.1 - 0.00049 20.0 0.0 0.0014 18.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX65189.1 - 0.029 15.1 0.0 0.13 13.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain UspB PF10625.9 ORX65192.1 - 0.28 11.2 2.0 0.31 11.0 0.2 1.9 2 0 0 2 2 2 0 Universal stress protein B (UspB) ETRAMP PF09716.10 ORX65193.1 - 0.036 14.1 0.3 0.054 13.6 0.3 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Glyco_hydro_18 PF00704.28 ORX65200.1 - 6.4e-46 157.5 5.5 1.1e-45 156.8 5.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 ORX65200.1 - 2.8e-07 30.9 12.7 2.8e-07 30.9 12.7 2.9 2 0 0 2 2 2 1 Chitin recognition protein PsaF PF17550.2 ORX65200.1 - 0.006 16.1 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function LysM PF01476.20 ORX65200.1 - 0.012 15.6 0.1 6.1 7.0 0.0 3.0 3 0 0 3 3 3 0 LysM domain UPA PF17217.3 ORX65205.1 - 0.049 13.5 0.0 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 UPA domain DUF4304 PF14137.6 ORX65206.1 - 0.13 12.4 1.8 0.45 10.7 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4304) dCMP_cyt_deam_1 PF00383.23 ORX65207.1 - 3.8e-10 39.6 0.0 5.7e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX65207.1 - 3.8e-08 33.2 0.0 5.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 ORX65207.1 - 0.0081 16.2 0.3 0.13 12.4 0.3 2.1 1 1 0 1 1 1 1 Bd3614-like deaminase DUF3086 PF11285.8 ORX65208.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) YkuI_C PF10388.9 ORX65217.1 - 0.039 13.8 0.6 0.42 10.4 0.2 2.3 1 1 1 2 2 2 0 EAL-domain associated signalling protein domain GW PF13457.6 ORX65217.1 - 0.26 11.9 2.6 6.3 7.5 0.1 3.2 2 1 1 3 3 3 0 GW (Gly-Tryp) dipeptide domain Phage_int_SAM_4 PF13495.6 ORX65219.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain FeoA PF04023.14 ORX65220.1 - 0.19 12.0 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 FeoA domain ABC_tran PF00005.27 ORX65221.1 - 1.1e-05 25.9 0.0 1.7e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter Phage_NinH PF06322.11 ORX65221.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Phage NinH protein Peptidase_M3 PF01432.20 ORX65224.1 - 3.2e-104 349.7 0.0 4.3e-104 349.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 MFS_1 PF07690.16 ORX65227.1 - 1.8e-15 56.7 15.2 3.4e-15 55.8 15.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily ABC_tran PF00005.27 ORX65233.1 - 2.4e-22 79.9 0.0 4.4e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX65233.1 - 6.6e-14 52.2 6.7 9.3e-07 28.8 0.4 2.2 1 1 1 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX65233.1 - 0.00015 21.2 0.1 0.0032 16.9 0.1 1.9 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX65233.1 - 0.0098 16.3 0.1 0.021 15.2 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 ORX65233.1 - 0.01 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 ORX65233.1 - 0.021 14.3 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ORX65233.1 - 0.031 14.5 0.6 0.27 11.5 0.6 2.1 1 1 0 1 1 1 0 AAA domain PDR_assoc PF08370.11 ORX65233.1 - 0.034 13.9 5.3 0.5 10.1 0.2 2.8 2 0 0 2 2 2 0 Plant PDR ABC transporter associated MMR_HSR1 PF01926.23 ORX65233.1 - 0.079 13.0 0.1 0.24 11.5 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX65233.1 - 0.14 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX65233.1 - 1.3 8.8 6.7 6 6.6 1.4 2.6 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF485 PF04341.12 ORX65233.1 - 5.6 7.0 7.1 1.4 8.9 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function, DUF485 Retrotrans_gag PF03732.17 ORX65234.1 - 0.027 14.7 0.2 0.057 13.7 0.2 1.5 1 0 0 1 1 1 0 Retrotransposon gag protein CLASP_N PF12348.8 ORX65235.1 - 1.4e-16 60.8 1.5 4.5e-08 32.9 0.0 6.7 4 3 1 5 5 5 3 CLASP N terminal HEAT PF02985.22 ORX65235.1 - 1.5e-15 56.0 4.1 0.016 15.4 0.0 8.5 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 ORX65235.1 - 3.1e-08 33.9 10.7 0.087 13.2 0.0 7.5 7 1 0 7 7 7 2 HEAT repeats Cnd1 PF12717.7 ORX65235.1 - 1.2e-06 28.7 0.4 1.6 8.7 0.0 5.6 5 1 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 TAN PF11640.8 ORX65235.1 - 0.00082 19.5 0.9 1.2 9.3 0.0 4.4 5 0 0 5 5 5 1 Telomere-length maintenance and DNA damage repair HEAT_EZ PF13513.6 ORX65235.1 - 0.083 13.4 17.1 0.79 10.3 0.0 6.7 7 1 1 8 8 8 0 HEAT-like repeat MMS19_N PF14500.6 ORX65235.1 - 0.1 12.2 2.9 3.7 7.1 0.0 4.5 6 0 0 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II MetRS-N PF09635.10 ORX65235.1 - 0.11 13.0 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 MetRS-N binding domain Pkinase PF00069.25 ORX65236.1 - 5.4e-35 121.0 0.0 6.3e-17 61.8 0.0 2.6 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65236.1 - 8.1e-10 38.4 0.1 1.9e-05 24.1 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX65236.1 - 0.00017 21.0 0.1 0.0034 16.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ORX65236.1 - 0.0094 15.9 0.4 0.096 12.6 0.6 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX65236.1 - 0.039 13.3 0.3 0.088 12.2 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX65236.1 - 0.12 11.3 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Inv-AAD PF18785.1 ORX65236.1 - 0.22 11.4 0.0 0.52 10.2 0.0 1.5 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase Aa_trans PF01490.18 ORX65237.1 - 1.3e-64 218.4 26.6 1.2e-63 215.3 26.6 1.9 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2484 PF10658.9 ORX65237.1 - 0.042 14.1 0.2 0.042 14.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) DUF2157 PF09925.9 ORX65237.1 - 0.18 11.6 10.6 0.22 11.3 4.0 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) GATA PF00320.27 ORX65239.1 - 2.8e-17 62.0 0.4 3.4e-17 61.7 0.4 1.1 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX65239.1 - 0.0039 16.7 1.3 0.0048 16.4 1.3 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding Auto_anti-p27 PF06677.12 ORX65239.1 - 0.046 13.9 0.8 0.06 13.5 0.8 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Vps36-NZF-N PF16988.5 ORX65239.1 - 0.056 12.8 0.3 3.3 7.2 0.0 2.1 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-ribbon_3 PF13248.6 ORX65239.1 - 0.29 10.6 2.4 6.6 6.3 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.27 ORX65240.1 - 9.7e-27 92.3 23.2 1.2e-15 56.9 1.3 3.4 4 0 0 4 4 4 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX65240.1 - 2e-06 27.2 6.8 0.0029 17.1 0.2 2.7 2 0 0 2 2 2 2 TFIIB zinc-binding NMD3 PF04981.13 ORX65240.1 - 0.039 13.4 1.6 0.91 8.9 0.1 2.3 2 0 0 2 2 2 0 NMD3 family Auto_anti-p27 PF06677.12 ORX65240.1 - 0.065 13.4 8.3 0.21 11.7 0.9 3.0 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) ABC2_membrane_4 PF12730.7 ORX65241.1 - 0.041 13.9 6.3 0.052 13.5 6.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Ig_2 PF13895.6 ORX65241.1 - 0.058 13.7 0.0 0.069 13.5 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain AbiEi_3_N PF17194.4 ORX65242.1 - 0.028 14.4 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain DUF2672 PF10878.8 ORX65242.1 - 0.096 12.6 3.6 2.7 8.0 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2672) BBE PF08031.12 ORX65242.1 - 0.14 12.3 0.4 0.39 10.9 0.4 1.7 1 0 0 1 1 1 0 Berberine and berberine like GATA PF00320.27 ORX65243.1 - 1e-26 92.3 23.3 1.1e-15 56.9 1.3 3.4 4 0 0 4 4 4 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX65243.1 - 1.8e-06 27.3 6.8 0.0028 17.1 0.2 2.8 2 0 0 2 2 2 2 TFIIB zinc-binding NMD3 PF04981.13 ORX65243.1 - 0.035 13.6 1.6 0.9 8.9 0.1 2.4 2 0 0 2 2 2 0 NMD3 family Auto_anti-p27 PF06677.12 ORX65243.1 - 0.066 13.4 8.3 0.21 11.8 0.9 2.9 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 ORX65243.1 - 10 6.4 9.2 7.4 6.8 0.1 3.5 3 0 0 3 3 3 0 Zinc ribbon domain Pyr_redox_2 PF07992.14 ORX65244.1 - 7.4e-53 179.7 0.0 9.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX65244.1 - 3.2e-13 50.0 0.0 1.4e-12 48.0 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX65244.1 - 0.0091 15.3 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX65244.1 - 0.14 11.7 0.4 1.5 8.3 0.0 2.3 1 1 0 2 2 2 0 FAD dependent oxidoreductase DsrC PF04358.13 ORX65244.1 - 0.15 12.6 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 DsrC like protein PT PF04886.12 ORX65246.1 - 0.005 16.3 2.2 0.012 15.1 2.2 1.6 1 0 0 1 1 1 1 PT repeat GLTT PF01744.20 ORX65246.1 - 0.037 13.8 0.7 0.075 12.8 0.7 1.5 1 0 0 1 1 1 0 GLTT repeat (6 copies) Pyr_redox_2 PF07992.14 ORX65248.1 - 4.6e-52 177.1 0.0 5.5e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX65248.1 - 5.4e-13 49.3 0.1 2.3e-12 47.3 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX65248.1 - 0.019 14.3 0.0 5.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PI3_PI4_kinase PF00454.27 ORX65249.1 - 2.8e-48 164.9 0.0 3.7e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ORX65249.1 - 2.1e-15 56.2 0.1 3.7e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 FATC domain CoA_transf_3 PF02515.17 ORX65253.1 - 9.1e-127 423.2 0.0 1.1e-126 422.9 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III AIRC PF00731.20 ORX65256.1 - 7.6e-64 213.8 0.1 1.6e-63 212.8 0.1 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ORX65256.1 - 1.6e-56 190.6 0.0 2.6e-56 189.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 ORX65256.1 - 9.7e-19 66.8 0.0 1.8e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 ORX65256.1 - 1.9e-06 27.5 0.0 3.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain 2-Hacid_dh_C PF02826.19 ORX65256.1 - 0.021 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX65256.1 - 0.039 13.3 0.1 0.26 10.6 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ATP-grasp_5 PF13549.6 ORX65256.1 - 0.073 12.5 0.0 0.27 10.6 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain RGS PF00615.19 ORX65257.1 - 8e-05 22.9 0.0 0.0078 16.5 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Cation_ATPase_C PF00689.21 ORX65261.1 - 3.6e-34 118.1 8.7 1.3e-31 109.7 2.8 2.5 1 1 1 2 2 2 2 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ORX65261.1 - 5.7e-20 71.6 7.4 7.5e-20 71.2 0.7 3.1 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX65261.1 - 4.7e-13 49.9 0.0 1.8e-12 48.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX65261.1 - 1.3e-08 34.4 0.0 3.2e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX65261.1 - 0.00042 20.1 0.1 0.015 15.1 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX65261.1 - 0.068 13.3 0.1 3.9 7.6 0.1 2.7 2 1 0 2 2 2 0 Cation transport ATPase (P-type) OPT PF03169.15 ORX65275.1 - 1.5e-153 512.7 55.1 1.2e-151 506.4 55.1 2.0 1 1 0 1 1 1 1 OPT oligopeptide transporter protein Tmemb_14 PF03647.13 ORX65275.1 - 2.9 8.7 9.2 4.4 8.1 0.6 4.3 4 0 0 4 4 4 0 Transmembrane proteins 14C Arrestin_N PF00339.29 ORX65276.1 - 1.5e-08 34.8 0.0 2.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX65276.1 - 9.4e-05 22.9 0.0 0.0042 17.5 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain FliJ PF02050.16 ORX65277.1 - 0.0049 17.1 0.9 0.0049 17.1 0.9 1.7 2 0 0 2 2 2 1 Flagellar FliJ protein FliJ PF02050.16 ORX65280.1 - 0.0049 17.1 0.9 0.0049 17.1 0.9 1.7 2 0 0 2 2 2 1 Flagellar FliJ protein Arrestin_N PF00339.29 ORX65281.1 - 1.5e-08 34.8 0.0 2.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX65281.1 - 9.4e-05 22.9 0.0 0.0042 17.5 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain AA_permease_2 PF13520.6 ORX65287.1 - 1.6e-05 23.9 0.2 2.3e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 Amino acid permease F-box-like PF12937.7 ORX65289.1 - 0.0038 17.1 0.4 0.012 15.5 0.4 2.0 1 0 0 1 1 1 1 F-box-like Herpes_gp2 PF05955.11 ORX65291.1 - 0.033 13.7 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Equine herpesvirus glycoprotein gp2 DUF1729 PF08354.10 ORX65311.1 - 1.3e-126 422.2 0.0 2.5e-126 421.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX65311.1 - 1.2e-49 168.8 0.0 2.1e-49 168.0 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX65311.1 - 2e-49 168.8 0.1 1.3e-48 166.2 0.1 2.3 3 0 0 3 3 3 1 Acyl transferase domain FAS_I_H PF18314.1 ORX65311.1 - 1.2e-42 145.9 0.6 2.6e-42 144.8 0.6 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX65311.1 - 1.2e-21 76.6 0.0 5.9e-21 74.3 0.0 2.1 2 0 0 2 2 2 1 MaoC like domain FAS_meander PF17951.1 ORX65311.1 - 7.4e-19 68.0 0.0 1.5e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX65311.1 - 9.3e-19 68.0 0.1 2.2e-18 66.8 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX65311.1 - 4.6e-18 65.8 0.0 9.1e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX65311.1 - 2.1e-14 53.5 0.0 4.9e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX65311.1 - 0.009 16.1 0.1 0.029 14.5 0.0 1.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX65311.1 - 0.011 15.7 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta PDDEXK_7 PF04411.12 ORX65312.1 - 0.074 13.0 0.3 0.11 12.5 0.2 1.4 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily OPT PF03169.15 ORX65313.1 - 2.1e-07 30.0 6.3 2.2e-07 29.9 6.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein TPR_9 PF13371.6 ORX65314.1 - 0.0041 17.2 0.0 2.2 8.5 0.0 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat LapA_dom PF06305.11 ORX65315.1 - 0.14 12.0 1.6 3.1 7.7 0.2 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Abhydrolase_9_N PF15420.6 ORX65315.1 - 0.81 9.7 6.9 0.13 12.3 2.7 1.7 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus E1-E2_ATPase PF00122.20 ORX65333.1 - 5.2e-50 169.5 1.1 5.2e-50 169.5 1.1 2.7 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX65333.1 - 8.5e-40 137.3 0.8 2.7e-39 135.7 0.4 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX65333.1 - 1.7e-24 86.0 0.0 7.8e-12 45.5 0.0 2.4 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ORX65333.1 - 9.2e-08 32.7 0.0 2.4e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX65333.1 - 2e-05 24.5 0.4 0.0068 16.2 0.2 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ALMT PF11744.8 ORX65333.1 - 0.13 11.0 0.5 0.27 10.0 0.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter EccE PF11203.8 ORX65333.1 - 0.79 10.1 7.5 5.4 7.4 0.0 4.0 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE UQ_con PF00179.26 ORX65334.1 - 6.4e-14 51.8 0.0 7.1e-14 51.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 ORX65334.1 - 0.011 15.4 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Peptidase_M56 PF05569.11 ORX65335.1 - 8.4 5.5 10.8 0.62 9.2 4.5 2.0 1 1 0 2 2 2 0 BlaR1 peptidase M56 MAR_sialic_bdg PF10564.9 ORX65337.1 - 1 9.4 10.9 0.29 11.2 1.5 2.5 3 0 0 3 3 3 0 Sialic-acid binding micronemal adhesive repeat Reprolysin_2 PF13574.6 ORX65338.1 - 1.9e-37 129.1 0.1 1.9e-37 129.1 0.1 1.6 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ORX65338.1 - 5.6e-32 111.5 0.6 1.2e-31 110.4 0.6 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ORX65338.1 - 1.6e-31 109.5 0.0 2.8e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 ORX65338.1 - 7.2e-14 52.4 0.0 1.6e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ORX65338.1 - 1.4e-07 32.2 24.3 1.4e-07 32.2 24.3 4.9 3 2 1 4 4 4 1 Disintegrin Reprolysin PF01421.19 ORX65338.1 - 1.5e-07 31.5 6.3 1.5e-07 31.5 6.3 2.6 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.9 ORX65338.1 - 0.0061 15.6 0.0 0.0097 14.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M54 PF07998.11 ORX65338.1 - 0.23 11.4 1.0 0.4 10.6 1.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Myosin_head PF00063.21 ORX65348.1 - 7.9e-98 328.4 2.1 9.8e-98 328.1 2.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 ORX65348.1 - 0.012 15.9 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX65348.1 - 0.032 14.6 0.0 0.043 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ORX65348.1 - 0.036 13.8 0.0 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 ORX65348.1 - 0.036 14.0 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ORX65348.1 - 0.041 13.4 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 ORX65348.1 - 0.048 12.7 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 ORX65348.1 - 0.05 13.5 0.2 0.087 12.7 0.2 1.4 1 0 0 1 1 1 0 NTPase Hpr_kinase_C PF07475.12 ORX65348.1 - 0.058 12.9 0.0 0.094 12.2 0.0 1.5 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_19 PF13245.6 ORX65348.1 - 0.079 13.3 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX65348.1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 ORX65348.1 - 0.094 11.6 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activat PF00158.26 ORX65348.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 ORX65348.1 - 0.14 11.5 0.1 0.28 10.4 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin zf-C2H2 PF00096.26 ORX65359.1 - 5.7e-09 35.9 13.0 4.1e-06 27.0 1.4 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX65359.1 - 0.00021 21.9 9.8 0.015 16.1 0.8 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX65359.1 - 0.0014 18.9 13.0 0.0018 18.6 1.1 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_8 PF15909.5 ORX65359.1 - 0.004 17.4 2.1 1.4 9.3 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX65359.1 - 0.026 15.1 0.9 3 8.6 0.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain DUF349 PF03993.12 ORX65361.1 - 0.26 11.6 10.7 0.15 12.3 3.4 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) EMP24_GP25L PF01105.24 ORX65361.1 - 0.55 10.2 2.9 0.92 9.4 2.9 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD MFS_1 PF07690.16 ORX65363.1 - 2.3e-44 151.7 45.2 3e-44 151.4 45.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX65363.1 - 7.5e-19 67.6 15.5 7.5e-19 67.6 15.5 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX65363.1 - 2.2e-12 46.6 14.3 2.2e-12 46.6 14.3 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TLC PF03219.14 ORX65363.1 - 0.62 8.7 10.2 0.027 13.2 3.7 2.0 2 1 0 2 2 2 0 TLC ATP/ADP transporter DUF2583 PF10762.9 ORX65363.1 - 7.5 7.0 6.7 61 4.1 0.1 4.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2583) DUF1240 PF06836.12 ORX65363.1 - 7.9 7.1 6.2 2.5 8.7 1.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1240) L31 PF09784.9 ORX65364.1 - 1.9e-33 115.0 0.3 2.1e-33 114.8 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Pkinase_fungal PF17667.1 ORX65375.1 - 4.1e-15 55.5 0.0 4.2e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ORX65375.1 - 0.0063 16.1 0.0 0.0066 16.1 0.0 1.0 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 ORX65375.1 - 0.05 13.0 0.1 0.05 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65375.1 - 0.067 12.5 0.1 0.067 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase NCBP3 PF10309.9 ORX65378.1 - 0.042 13.7 0.0 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 ORX65378.1 - 0.085 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 RNA binding domain LPMO_10 PF03067.15 ORX65410.1 - 0.0026 18.5 1.0 0.0061 17.2 1.0 1.5 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading LPMO_10 PF03067.15 ORX65411.1 - 8.3e-08 33.1 0.0 9.3e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading LPMO_10 PF03067.15 ORX65412.1 - 9.1e-06 26.5 0.0 1.5e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX65412.1 - 0.00096 19.1 0.8 0.015 15.3 0.4 2.7 1 1 1 2 2 2 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 ORX65413.1 - 7.1e-06 26.8 0.0 7.1e-06 26.8 0.0 2.2 2 1 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX65413.1 - 4.7e-05 23.4 0.3 0.0003 20.8 0.3 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_19 PF03427.13 ORX65413.1 - 0.025 14.6 6.4 0.025 14.6 6.4 2.3 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) RNA_pol_Rpc4 PF05132.14 ORX65413.1 - 1.3 9.4 7.8 59 4.1 7.8 2.8 1 1 0 1 1 1 0 RNA polymerase III RPC4 WD40 PF00400.32 ORX65414.1 - 2.6e-17 62.9 29.8 0.0032 18.3 0.1 10.4 12 0 0 12 12 12 5 WD domain, G-beta repeat DUF1668 PF07893.13 ORX65414.1 - 0.013 14.9 0.0 0.038 13.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) RTP1_C1 PF10363.9 ORX65415.1 - 1.8e-30 105.4 0.3 3.6e-29 101.2 0.0 3.2 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ORX65415.1 - 5.1e-06 26.8 13.4 0.014 15.8 0.2 4.9 4 0 0 4 4 4 2 HEAT repeats RTP1_C2 PF10304.9 ORX65415.1 - 0.00045 19.8 2.8 0.0014 18.3 1.2 2.5 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 Spidroin_MaSp PF11260.8 ORX65415.1 - 0.016 15.5 0.6 0.094 13.0 0.1 2.6 2 0 0 2 2 2 0 Major ampullate spidroin 1 and 2 BRO1 PF03097.18 ORX65415.1 - 0.078 11.8 0.0 0.19 10.5 0.0 1.6 1 0 0 1 1 1 0 BRO1-like domain AAA_lid_7 PF17867.1 ORX65415.1 - 0.13 12.5 0.1 17 5.6 0.0 4.0 3 0 0 3 3 3 0 Midasin AAA lid domain Methyltransf_3 PF01596.17 ORX65418.1 - 4.4e-36 124.1 0.0 5.2e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX65418.1 - 4.7e-14 53.3 0.2 9.5e-14 52.3 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 ORX65418.1 - 0.019 14.7 0.0 0.031 13.9 0.0 1.4 2 0 0 2 2 2 0 Cephalosporin hydroxylase PCMT PF01135.19 ORX65418.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ORX65418.1 - 0.034 14.8 0.0 0.074 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Herpes_BLLF1 PF05109.13 ORX65420.1 - 0.00063 17.9 53.0 0.00063 17.9 53.0 6.1 1 1 6 7 7 7 2 Herpes virus major outer envelope glycoprotein (BLLF1) DUF2600 PF10776.9 ORX65421.1 - 0.06 12.2 0.4 0.077 11.9 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) LPP PF04728.13 ORX65421.1 - 0.59 10.6 6.4 2.1 8.8 1.3 2.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DUF1295 PF06966.12 ORX65422.1 - 6.9e-33 114.1 4.1 8e-33 113.9 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ORX65422.1 - 0.0023 18.3 0.3 0.012 16.0 0.0 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF2207 PF09972.9 ORX65423.1 - 0.00035 19.5 0.0 0.00043 19.2 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 ORX65423.1 - 0.009 16.9 0.0 0.071 14.0 0.0 2.2 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain DUF4366 PF14283.6 ORX65423.1 - 0.013 15.5 2.2 0.14 12.2 2.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) SKG6 PF08693.10 ORX65423.1 - 0.022 14.1 0.3 0.074 12.5 0.3 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RNA_pol_Rpc4 PF05132.14 ORX65423.1 - 0.024 15.1 4.3 2.1 8.8 0.0 2.5 3 0 0 3 3 3 0 RNA polymerase III RPC4 VSP PF03302.13 ORX65423.1 - 0.044 12.7 6.7 0.12 11.2 6.7 1.7 1 1 0 1 1 1 0 Giardia variant-specific surface protein Beta-APP PF03494.13 ORX65423.1 - 0.12 12.2 3.2 0.26 11.1 3.2 1.5 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) stn_TNFRSF12A PF12191.8 ORX65423.1 - 0.26 11.5 0.1 0.26 11.5 0.1 3.0 2 2 2 4 4 4 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Plasmodium_Vir PF05795.11 ORX65423.1 - 0.42 10.0 2.4 0.87 8.9 2.4 1.4 1 1 0 1 1 1 0 Plasmodium vivax Vir protein PRKCSH-like PF12999.7 ORX65424.1 - 6.3e-48 162.9 3.6 1.7e-47 161.5 3.6 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 ORX65424.1 - 1e-26 93.4 0.1 3.1e-26 91.9 0.1 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 ORX65424.1 - 9.2e-09 36.2 1.3 3.1e-08 34.5 0.6 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Complex1_LYR_2 PF13233.6 ORX65424.1 - 7.5 7.4 8.9 2.1 9.1 5.3 1.9 2 0 0 2 2 2 0 Complex1_LYR-like adh_short_C2 PF13561.6 ORX65425.1 - 4.8e-44 150.7 0.3 5.6e-44 150.5 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX65425.1 - 3.5e-38 131.0 0.2 5e-38 130.5 0.0 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ORX65425.1 - 6e-11 42.6 0.0 1.5e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX65425.1 - 0.0059 16.0 0.1 0.0075 15.7 0.1 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 ORX65425.1 - 0.021 14.8 0.0 0.044 13.8 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Glyco_transf_5 PF08323.11 ORX65425.1 - 0.037 13.7 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Starch synthase catalytic domain Herpes_glycoH_C PF17488.2 ORX65425.1 - 0.055 13.3 0.3 2.1 8.1 0.2 2.9 2 1 0 2 2 2 0 Herpesvirus glycoprotein H C-terminal domain GDP_Man_Dehyd PF16363.5 ORX65425.1 - 0.16 11.3 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Metallophos PF00149.28 ORX65429.1 - 0.0016 18.9 0.0 0.0022 18.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nucleoporin_FG PF13634.6 ORX65430.1 - 1.8e-33 115.2 154.6 6e-12 46.3 29.8 4.6 2 1 3 5 5 5 4 Nucleoporin FG repeat region DUF677 PF05055.12 ORX65430.1 - 0.0006 18.8 2.7 0.00065 18.7 1.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF677) CheZ PF04344.13 ORX65430.1 - 0.17 11.8 2.3 0.11 12.4 0.3 1.7 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Meth_synt_1 PF08267.12 ORX65430.1 - 0.18 11.3 0.1 0.26 10.7 0.1 1.1 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain TFA2_Winged_2 PF18121.1 ORX65430.1 - 0.39 10.5 0.8 0.69 9.6 0.8 1.4 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Filament PF00038.21 ORX65430.1 - 1.7 8.1 5.1 1.1 8.8 1.8 2.1 2 1 1 3 3 3 0 Intermediate filament protein WD40 PF00400.32 ORX65431.1 - 2e-51 170.8 10.2 5.3e-08 33.4 0.8 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65431.1 - 4.5e-17 62.1 0.4 0.00097 19.4 0.0 5.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX65431.1 - 1.8e-13 50.0 6.4 0.0036 16.0 0.0 5.9 3 1 3 6 6 6 5 Nucleoporin Nup120/160 LisH PF08513.11 ORX65431.1 - 0.016 15.1 0.1 0.028 14.4 0.1 1.4 1 0 0 1 1 1 0 LisH DUF1652 PF07865.11 ORX65431.1 - 0.078 12.8 0.1 5.9 6.8 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1652) Pox_A_type_inc PF04508.12 ORX65431.1 - 0.46 10.4 1.6 1 9.3 0.6 2.1 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat DAP_B PF07930.12 ORX65432.1 - 0.044 13.8 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 D-aminopeptidase, domain B DNA_meth_N PF18284.1 ORX65432.1 - 0.062 13.2 1.9 0.07 13.0 0.1 2.1 2 0 0 2 2 2 0 DNA methylase N-terminal domain SNF2_N PF00176.23 ORX65433.1 - 7.8e-15 54.4 0.0 1.3e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX65433.1 - 3e-13 50.1 0.0 7.5e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_S10 PF00450.22 ORX65440.1 - 1.5e-93 314.5 0.1 8.5e-74 249.4 0.1 2.0 1 1 1 2 2 2 2 Serine carboxypeptidase Lipase PF00151.19 ORX65440.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 Lipase Peptidase_S10 PF00450.22 ORX65441.1 - 3.9e-75 253.8 0.7 2.1e-56 192.1 0.9 3.9 1 1 2 3 3 3 3 Serine carboxypeptidase DUF3533 PF12051.8 ORX65454.1 - 1.4e-06 27.5 4.8 1.8e-06 27.1 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF454 PF04304.13 ORX65454.1 - 0.0099 15.9 0.6 0.013 15.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF454) DUF4246 PF14033.6 ORX65455.1 - 6.9e-64 216.6 0.0 9e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ORX65455.1 - 0.095 13.1 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Bac_chlorC PF02043.17 ORX65456.1 - 0.034 14.1 0.1 0.065 13.2 0.1 1.5 1 1 0 1 1 1 0 Bacteriochlorophyll C binding protein Choline_kinase PF01633.20 ORX65456.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase E1-E2_ATPase PF00122.20 ORX65480.1 - 1.5e-24 86.5 0.6 6.2e-24 84.5 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX65480.1 - 1e-08 35.7 0.1 0.00057 20.2 0.1 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX65480.1 - 0.0028 17.7 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX65480.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus DUF4381 PF14316.6 ORX65480.1 - 3.4 7.9 5.4 2.9 8.1 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) CTC1 PF15489.6 ORX65481.1 - 3.8e-09 34.7 10.9 8.3e-05 20.3 0.0 3.1 3 0 0 3 3 3 3 CST, telomere maintenance, complex subunit CTC1 zf-RanBP PF00641.18 ORX65482.1 - 4.4e-07 29.1 19.2 0.00037 19.7 3.1 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-C2H2 PF00096.26 ORX65483.1 - 1.7e-07 31.3 13.6 0.00065 20.0 2.7 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX65483.1 - 7.4e-05 23.3 10.4 0.037 14.9 2.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX65483.1 - 0.00016 21.9 4.3 0.00016 21.9 4.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX65483.1 - 0.0011 18.9 7.8 0.0064 16.5 0.1 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 ORX65483.1 - 0.0067 16.8 1.7 0.17 12.3 0.3 2.5 2 1 0 2 2 2 1 Zinc-finger of C2H2 type HNH PF01844.23 ORX65483.1 - 0.017 15.2 2.1 0.083 13.1 2.1 2.0 1 1 0 1 1 1 0 HNH endonuclease zf-C2H2_8 PF15909.5 ORX65483.1 - 0.019 15.3 0.5 0.023 15.0 0.5 1.2 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX65483.1 - 0.044 13.5 2.3 0.044 13.5 2.3 1.7 2 0 0 2 2 2 0 zinc-finger C2H2-type EamA PF00892.20 ORX65484.1 - 4.9e-22 78.6 23.1 1.6e-12 47.7 8.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family GT87 PF09594.10 ORX65486.1 - 0.0066 16.2 0.0 0.0068 16.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 87 TENA_THI-4 PF03070.16 ORX65486.1 - 0.052 13.3 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 TENA/THI-4/PQQC family FAD_binding_1 PF00667.20 ORX65489.1 - 2.8e-45 154.6 0.0 4.3e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX65489.1 - 1.7e-33 115.8 0.1 3.4e-33 114.9 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX65489.1 - 1.5e-15 57.7 0.0 4.7e-15 56.2 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain AAA PF00004.29 ORX65490.1 - 5.2e-39 133.7 0.0 9.2e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX65490.1 - 3.3e-12 46.0 0.1 6.8e-12 45.0 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ORX65490.1 - 1.4e-05 25.4 0.1 0.0022 18.3 0.1 2.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 ORX65490.1 - 1.7e-05 24.2 0.1 6.1e-05 22.4 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 ORX65490.1 - 2.4e-05 24.1 0.0 0.00011 22.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ORX65490.1 - 5.4e-05 23.7 0.0 0.00021 21.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX65490.1 - 7.3e-05 22.2 0.5 0.0021 17.4 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ORX65490.1 - 8.7e-05 23.0 4.1 0.0051 17.2 0.1 3.3 2 2 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 ORX65490.1 - 0.00017 21.7 0.0 0.00038 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ORX65490.1 - 0.00023 21.2 0.5 0.002 18.1 0.5 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX65490.1 - 0.00044 20.4 0.0 0.0019 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ORX65490.1 - 0.00092 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 ORX65490.1 - 0.0049 16.6 0.0 0.0092 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX65490.1 - 0.0057 16.2 0.1 0.035 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX65490.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX65490.1 - 0.008 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ORX65490.1 - 0.0095 16.2 0.3 3.8 7.7 0.0 2.5 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain DUF815 PF05673.13 ORX65490.1 - 0.014 14.6 0.0 0.033 13.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ORX65490.1 - 0.019 15.3 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 ORX65490.1 - 0.02 14.3 0.0 1.4 8.2 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 ORX65490.1 - 0.023 14.2 0.1 0.061 12.8 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 ORX65490.1 - 0.047 13.0 0.1 1.2 8.4 0.1 2.3 1 1 1 2 2 2 0 KaiC IPT PF01745.16 ORX65490.1 - 0.062 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Parvo_NS1 PF01057.17 ORX65490.1 - 0.066 12.3 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 ORX65490.1 - 0.075 12.9 0.2 0.28 11.1 0.1 2.0 3 0 0 3 3 3 0 NACHT domain PhoH PF02562.16 ORX65490.1 - 0.095 12.1 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 ORX65490.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE bZIP_2 PF07716.15 ORX65491.1 - 8.8e-08 32.1 19.2 9.4e-08 32.0 15.3 2.5 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX65491.1 - 0.0017 18.4 14.9 0.66 10.1 11.3 2.3 2 0 0 2 2 2 2 bZIP transcription factor DUF1465 PF07323.12 ORX65491.1 - 0.056 13.3 11.4 0.066 13.0 10.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) FUSC PF04632.12 ORX65491.1 - 0.44 9.0 5.4 0.47 8.9 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Peptidase_S64 PF08192.11 ORX65491.1 - 0.71 8.3 4.0 0.92 7.9 4.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Pex26 PF07163.12 ORX65491.1 - 1.2 8.4 10.0 11 5.2 10.0 2.1 1 1 0 1 1 1 0 Pex26 protein SNF5 PF04855.12 ORX65492.1 - 9.3e-54 182.7 0.3 1.9e-30 106.4 0.0 2.0 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 EF-hand_11 PF08976.11 ORX65492.1 - 0.021 15.7 0.1 7.9 7.4 0.0 3.0 2 1 1 3 3 3 0 EF-hand domain Gcn1_N PF12074.8 ORX65494.1 - 6.5e-06 25.7 0.1 1.1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal ABC_tran PF00005.27 ORX65506.1 - 1e-15 58.4 0.1 1e-12 48.8 0.1 2.5 1 1 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ORX65506.1 - 8.8e-06 26.4 0.1 1.6e-05 25.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX65506.1 - 9.7e-06 25.3 0.1 4.5e-05 23.1 0.0 2.0 1 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 ORX65506.1 - 0.00032 20.2 0.1 0.17 11.3 0.1 2.5 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX65506.1 - 0.00069 19.3 0.1 0.0017 18.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_membrane_2 PF06472.15 ORX65506.1 - 0.0019 17.6 0.1 0.0039 16.6 0.1 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 T2SSE PF00437.20 ORX65506.1 - 0.037 13.1 0.0 0.076 12.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ORX65506.1 - 0.039 13.9 0.3 0.15 12.0 0.3 1.8 1 1 0 2 2 2 0 RsgA GTPase ABC_membrane PF00664.23 ORX65506.1 - 0.044 13.4 1.0 0.13 11.9 1.0 1.8 1 1 0 1 1 1 0 ABC transporter transmembrane region AAA_16 PF13191.6 ORX65506.1 - 0.05 14.0 0.8 0.15 12.5 0.6 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 ORX65506.1 - 0.072 12.9 1.3 0.15 11.8 0.7 1.8 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Adeno_IVa2 PF02456.15 ORX65506.1 - 0.1 11.4 0.1 0.17 10.6 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein Fe_hyd_SSU PF02256.17 ORX65506.1 - 0.12 12.4 0.0 12 6.1 0.0 2.5 2 0 0 2 2 2 0 Iron hydrogenase small subunit Peptidase_M28 PF04389.17 ORX65507.1 - 2.9e-32 112.0 0.0 3.8e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX65507.1 - 1.1e-08 35.0 0.1 2.4e-08 33.9 0.1 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ORX65507.1 - 2.2e-05 23.7 0.1 0.0016 17.5 0.0 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Nicastrin PF05450.15 ORX65507.1 - 0.001 18.6 0.0 0.0043 16.5 0.0 1.8 2 0 0 2 2 2 1 Nicastrin p450 PF00067.22 ORX65508.1 - 4.7e-51 174.0 0.0 7e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CorA PF01544.18 ORX65510.1 - 2.4e-30 105.8 0.0 3.2e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Pex24p PF06398.11 ORX65511.1 - 0.00085 18.4 8.2 0.0012 17.9 8.2 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Radical_SAM_C PF16199.5 ORX65514.1 - 1.1e-32 111.8 0.0 2.5e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ORX65514.1 - 7.1e-18 65.5 0.3 4.2e-17 63.0 0.0 2.4 4 0 0 4 4 4 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ORX65514.1 - 1.5e-10 41.3 0.0 3.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX65514.1 - 1.1e-06 28.6 0.0 2.9e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX65514.1 - 0.00018 21.8 0.0 0.00039 20.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX65514.1 - 0.0075 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein RAI16-like PF10257.9 ORX65515.1 - 1.7e-32 112.7 0.0 5.6e-32 111.0 0.0 1.8 1 1 0 1 1 1 1 Retinoic acid induced 16-like protein CorA PF01544.18 ORX65516.1 - 1.2e-28 100.3 0.0 1.5e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein tRNA-synt_2b PF00587.25 ORX65517.1 - 4.4e-24 85.4 0.0 7.1e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX65517.1 - 1.5e-10 41.2 2.9 2.7e-10 40.4 2.9 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain BBP1_C PF15272.6 ORX65517.1 - 0.016 15.0 0.8 0.025 14.4 0.8 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Syntaxin-6_N PF09177.11 ORX65517.1 - 0.05 14.2 1.0 0.3 11.7 1.0 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal FPP PF05911.11 ORX65517.1 - 0.1 10.7 3.1 0.14 10.4 3.1 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil BLOC1_2 PF10046.9 ORX65517.1 - 1.5 9.2 4.6 1.8 8.9 1.8 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AMP-binding PF00501.28 ORX65518.1 - 9.1e-19 67.3 0.1 9.5e-19 67.3 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX65519.1 - 0.064 14.2 0.1 0.13 13.3 0.1 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DAGAT PF03982.13 ORX65520.1 - 1.1e-67 228.1 0.0 1.4e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase VirB3 PF05101.13 ORX65520.1 - 0.014 15.6 5.9 4.3 7.6 1.7 3.3 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein Vezatin PF12632.7 ORX65521.1 - 1.2e-10 41.2 1.4 8.2e-10 38.5 1.4 2.1 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes CorA PF01544.18 ORX65522.1 - 5.5e-29 101.4 0.0 6.5e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein RAI16-like PF10257.9 ORX65523.1 - 1.7e-32 112.7 0.0 5.6e-32 111.0 0.0 1.8 1 1 0 1 1 1 1 Retinoic acid induced 16-like protein Mucin PF01456.17 ORX65523.1 - 3.7 7.5 10.5 7.8 6.5 6.8 2.8 2 0 0 2 2 2 0 Mucin-like glycoprotein Radical_SAM_C PF16199.5 ORX65524.1 - 1.1e-32 111.8 0.0 2.5e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ORX65524.1 - 7.1e-18 65.5 0.3 4.2e-17 63.0 0.0 2.4 4 0 0 4 4 4 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ORX65524.1 - 1.5e-10 41.3 0.0 3.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX65524.1 - 1.1e-06 28.6 0.0 2.9e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX65524.1 - 0.00018 21.8 0.0 0.00039 20.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX65524.1 - 0.0075 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Pex24p PF06398.11 ORX65526.1 - 0.00086 18.4 8.2 0.0012 17.9 8.2 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin RCDG1 PF15725.5 ORX65526.1 - 1.8 9.1 11.7 0.082 13.3 3.4 2.9 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein CorA PF01544.18 ORX65527.1 - 2.2e-30 106.0 0.0 3e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein p450 PF00067.22 ORX65529.1 - 2.5e-62 211.2 0.0 3.3e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M28 PF04389.17 ORX65532.1 - 4.4e-31 108.1 0.0 6.1e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX65532.1 - 1.9e-08 34.3 0.0 3.2e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ORX65532.1 - 7.9e-05 21.8 0.1 0.0019 17.3 0.0 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Nicastrin PF05450.15 ORX65532.1 - 0.0013 18.3 0.0 0.0053 16.3 0.0 1.8 2 0 0 2 2 2 1 Nicastrin ABC_tran PF00005.27 ORX65533.1 - 1.4e-11 45.1 0.0 6.8e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX65533.1 - 2.1e-10 40.8 3.6 2.1e-10 40.8 3.6 4.3 4 1 0 4 4 4 2 ABC transporter transmembrane region DUF4904 PF16247.5 ORX65534.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4904) MliC PF09864.9 ORX65535.1 - 0.11 12.4 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme DUF1631 PF07793.11 ORX65538.1 - 0.54 8.6 9.0 0.63 8.4 9.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) RabGAP-TBC PF00566.18 ORX65539.1 - 1.1e-31 110.2 0.0 1.5e-31 109.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Csm1_B PF18211.1 ORX65558.1 - 0.055 13.3 0.0 0.062 13.1 0.0 1.1 1 0 0 1 1 1 0 Csm1 subunit domain B AKAP7_NLS PF10469.9 ORX65559.1 - 3.6e-29 102.2 0.0 5.4e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX65559.1 - 1.9e-05 24.6 0.0 6.6e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily HU-CCDC81_bac_2 PF18175.1 ORX65559.1 - 0.16 11.8 0.1 1.4 8.9 0.0 2.4 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Chromo PF00385.24 ORX65560.1 - 7.7e-10 38.5 0.7 1.2e-09 37.9 0.7 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 ORX65560.1 - 0.15 12.2 0.7 0.28 11.4 0.7 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 AMPK1_CBM PF16561.5 ORX65561.1 - 3.2e-07 30.5 0.0 5.6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Pur_ac_phosph_N PF16656.5 ORX65561.1 - 0.0098 16.4 0.0 0.057 14.0 0.0 2.3 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain CBM_48 PF02922.18 ORX65561.1 - 0.02 15.2 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) LisH PF08513.11 ORX65562.1 - 0.00047 20.0 0.4 0.00084 19.2 0.4 1.4 1 0 0 1 1 1 1 LisH LSM PF01423.22 ORX65563.1 - 1.6e-11 43.7 0.7 1.9e-11 43.5 0.7 1.1 1 0 0 1 1 1 1 LSM domain DUF229 PF02995.17 ORX65580.1 - 2e-26 92.7 2.3 5.2e-21 74.8 0.5 3.5 1 1 1 2 2 2 2 Protein of unknown function (DUF229) Sulfatase PF00884.23 ORX65580.1 - 1.4e-05 24.7 0.1 0.00019 20.9 0.1 2.6 1 1 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 ORX65580.1 - 0.035 13.2 0.1 0.067 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF1435 PF07256.12 ORX65580.1 - 0.37 10.9 3.1 0.93 9.6 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1435) DUF2070 PF09843.9 ORX65580.1 - 0.65 8.2 6.2 0.95 7.7 6.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Rhomboid PF01694.22 ORX65582.1 - 6.7e-06 26.2 0.2 1.2e-05 25.4 0.0 1.5 2 0 0 2 2 2 1 Rhomboid family BTB PF00651.31 ORX65583.1 - 7.8e-15 55.1 0.0 1.7e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain PAW PF04721.17 ORX65583.1 - 4.4e-14 52.7 0.0 1.3e-11 44.6 0.0 2.2 2 0 0 2 2 2 2 PNGase C-terminal domain, mannose-binding module PAW Histone PF00125.24 ORX65594.1 - 3.5e-07 30.7 1.1 3.7e-07 30.5 1.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 ORX65594.1 - 0.00049 20.7 3.1 0.00049 20.7 3.1 1.0 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 ORX65595.1 - 2.6e-08 33.9 0.1 3.2e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX65595.1 - 5.9e-05 23.1 0.1 8.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ORX65595.1 - 9.7e-05 22.7 0.1 0.00013 22.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ORX65595.1 - 0.0002 21.7 0.2 0.00023 21.6 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX65595.1 - 0.00035 20.8 0.1 0.00068 19.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX65595.1 - 0.02 14.9 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX65595.1 - 0.059 13.4 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 ORX65595.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A DUSP PF06337.12 ORX65596.1 - 2.8e-09 37.5 0.0 6.1e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 DUSP domain UCH PF00443.29 ORX65596.1 - 0.00017 21.2 0.0 0.044 13.3 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PTPRCAP PF15713.5 ORX65596.1 - 0.032 14.5 5.7 0.1 12.9 5.7 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Pro_isomerase PF00160.21 ORX65597.1 - 4.3e-48 163.6 0.0 5.2e-48 163.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 ORX65597.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) RRM_1 PF00076.22 ORX65598.1 - 8.3e-19 67.2 0.0 2.3e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 ORX65598.1 - 2.4e-09 36.6 4.6 2.4e-09 36.6 4.6 2.4 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 ORX65598.1 - 4.7e-07 30.2 2.0 3.3e-06 27.5 0.0 2.3 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_7 PF16367.5 ORX65598.1 - 0.02 15.0 0.1 0.11 12.6 0.0 2.3 3 0 0 3 3 3 0 RNA recognition motif SRA1 PF07304.11 ORX65598.1 - 1.8 8.4 4.1 4.8 7.0 1.4 2.1 2 0 0 2 2 2 0 Steroid receptor RNA activator (SRA1) Aminotran_1_2 PF00155.21 ORX65599.1 - 3e-18 66.1 0.0 1.5e-16 60.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II DUF4500 PF14937.6 ORX65600.1 - 1.6e-10 40.9 0.0 5.8e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4500) HhH-GPD PF00730.25 ORX65601.1 - 1.7e-14 54.2 0.0 2e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein FHA PF00498.26 ORX65602.1 - 4.6e-10 39.7 0.1 2.1e-09 37.6 0.1 2.0 1 1 0 1 1 1 1 FHA domain OCRE PF17780.1 ORX65602.1 - 0.023 14.7 0.6 0.071 13.1 0.6 1.8 1 0 0 1 1 1 0 OCRE domain MTS PF05175.14 ORX65603.1 - 1.9e-10 40.5 0.0 3.6e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ORX65603.1 - 5.7e-09 35.9 0.0 1.1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX65603.1 - 3.8e-07 30.7 0.0 9.1e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX65603.1 - 6.7e-07 29.3 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX65603.1 - 1.3e-06 28.1 0.0 2.2e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ORX65603.1 - 0.00062 20.5 0.0 0.0014 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PseudoU_synth_2 PF00849.22 ORX65603.1 - 0.0015 18.7 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase UPF0020 PF01170.18 ORX65603.1 - 0.0016 18.2 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DOT1 PF08123.13 ORX65603.1 - 0.014 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 ORX65603.1 - 0.019 15.6 0.0 0.057 14.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_10 PF05971.12 ORX65603.1 - 0.052 12.9 0.1 0.2 11.0 0.1 1.8 1 1 0 1 1 1 0 RNA methyltransferase Fcf1 PF04900.12 ORX65604.1 - 1.4e-24 86.3 0.1 4.2e-24 84.8 0.0 1.8 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 ORX65604.1 - 0.0036 17.6 0.9 0.016 15.5 0.2 2.2 2 1 1 3 3 3 2 PIN like domain BCAS2 PF05700.11 ORX65605.1 - 1.3e-62 211.2 2.7 1.5e-62 211.0 2.7 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) NUDE_C PF04880.13 ORX65606.1 - 5.7e-08 33.4 7.4 5.7e-08 33.4 7.4 2.6 2 1 0 2 2 1 1 NUDE protein, C-terminal conserved region DUF2353 PF09789.9 ORX65606.1 - 0.00021 20.8 22.6 0.0031 16.9 11.6 2.3 1 1 1 2 2 2 2 Uncharacterized coiled-coil protein (DUF2353) Flg_hook PF02120.16 ORX65606.1 - 0.032 14.1 0.9 11 6.0 0.2 2.9 2 1 0 2 2 2 0 Flagellar hook-length control protein FliK CCDC92 PF14916.6 ORX65606.1 - 0.052 13.3 5.0 2.4 8.0 0.1 3.6 3 0 0 3 3 3 0 Coiled-coil domain of unknown function Spc7 PF08317.11 ORX65606.1 - 0.071 12.0 22.5 0.49 9.2 7.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ORX65606.1 - 0.096 13.1 11.9 2.4 8.6 0.3 5.2 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) ATG16 PF08614.11 ORX65606.1 - 0.27 11.4 33.1 0.21 11.8 14.1 3.1 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.12 ORX65606.1 - 0.28 11.1 9.4 5.3 7.1 0.0 4.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Fez1 PF06818.15 ORX65606.1 - 0.34 11.3 24.0 19 5.7 24.0 2.5 1 1 0 1 1 1 0 Fez1 E2R135 PF11570.8 ORX65606.1 - 0.41 10.9 7.5 2.1 8.6 0.1 3.1 1 1 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 LMBR1 PF04791.16 ORX65606.1 - 0.94 8.3 7.5 1.3 7.9 7.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 ORX65606.1 - 1.2 9.8 15.9 24 5.6 3.5 4.0 1 1 2 4 4 4 0 Initiation control protein YabA ADIP PF11559.8 ORX65606.1 - 2.7 8.1 21.6 4.6 7.3 5.9 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 ORX65606.1 - 3.4 6.7 20.4 2.5 7.1 17.7 2.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 ORX65606.1 - 3.8 7.6 31.6 0.18 11.9 16.1 3.8 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 ORX65606.1 - 6.8 6.7 25.9 0.99 9.5 9.0 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Surp PF01805.20 ORX65607.1 - 6.5e-14 51.7 0.2 4.9e-07 29.7 0.1 2.5 2 0 0 2 2 2 2 Surp module DRY_EERY PF09750.9 ORX65607.1 - 0.00014 22.1 1.3 0.00068 19.9 0.2 2.3 2 0 0 2 2 2 1 Alternative splicing regulator Glyco_hydro_15 PF00723.21 ORX65608.1 - 0.00058 18.8 0.0 0.00067 18.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.21 ORX65609.1 - 1.4e-31 109.7 1.3 1e-23 83.9 2.3 3.0 2 1 1 3 3 3 3 Glycosyl hydrolases family 15 DUF5530 PF17670.1 ORX65609.1 - 0.086 12.6 0.1 11 5.8 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5530) COPI_assoc PF08507.10 ORX65610.1 - 0.033 14.2 3.1 0.076 13.1 3.1 1.5 1 1 0 1 1 1 0 COPI associated protein Actin PF00022.19 ORX65611.1 - 4.1e-30 104.7 0.0 6.5e-16 57.9 0.0 2.9 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 ORX65611.1 - 3e-13 49.7 0.4 2.7e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 ORX65611.1 - 0.0031 16.4 0.0 0.0093 14.8 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 ORX65611.1 - 0.069 13.6 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 Cell division protein FtsA DUF3381 PF11861.8 ORX65611.1 - 0.41 10.4 1.3 0.66 9.7 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) TAF4 PF05236.14 ORX65611.1 - 0.75 9.5 5.4 1.4 8.6 5.4 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Complex1_LYR PF05347.15 ORX65612.1 - 7.6e-11 41.9 0.0 2.1e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 Complex 1 protein (LYR family) PPR PF01535.20 ORX65612.1 - 6.1e-10 38.7 1.7 0.054 13.8 0.0 7.2 6 1 1 7 7 7 2 PPR repeat PPR_2 PF13041.6 ORX65612.1 - 3.3e-08 33.6 0.1 1.3 9.3 0.0 6.4 6 1 0 6 6 6 2 PPR repeat family PPR_long PF17177.4 ORX65612.1 - 0.00024 20.5 0.0 0.031 13.7 0.0 3.7 2 1 4 6 6 6 2 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ORX65612.1 - 0.014 15.9 0.0 0.052 14.1 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Complex1_LYR_2 PF13233.6 ORX65612.1 - 0.031 15.0 0.0 0.11 13.3 0.0 1.9 2 0 0 2 2 2 0 Complex1_LYR-like Complex1_LYR_1 PF13232.6 ORX65612.1 - 0.059 14.0 0.0 0.19 12.4 0.0 1.9 1 0 0 1 1 1 0 Complex1_LYR-like ATP13 PF12921.7 ORX65612.1 - 0.079 12.8 0.1 4.7 7.1 0.0 3.0 2 1 2 4 4 4 0 Mitochondrial ATPase expression DEAD PF00270.29 ORX65613.1 - 7.5e-40 136.5 0.4 1.2e-39 135.9 0.4 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX65613.1 - 3.9e-30 104.4 0.1 2.7e-28 98.5 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX65613.1 - 3.9e-05 23.7 0.8 9.6e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit BSP_II PF05432.11 ORX65613.1 - 0.00013 21.8 7.6 0.0002 21.2 7.6 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) CDC45 PF02724.14 ORX65613.1 - 0.00044 18.7 1.1 0.00064 18.2 1.1 1.2 1 0 0 1 1 1 1 CDC45-like protein GAGA_bind PF06217.12 ORX65613.1 - 0.13 12.5 3.6 0.3 11.3 0.5 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family RNA_pol_Rpc4 PF05132.14 ORX65613.1 - 0.54 10.7 5.8 1.3 9.5 5.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_polI_A34 PF08208.11 ORX65613.1 - 0.55 10.3 15.5 1.5 8.9 15.5 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TFIIF_alpha PF05793.12 ORX65613.1 - 0.75 8.3 19.3 1.3 7.5 19.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 PF03666.13 ORX65613.1 - 4.6 5.9 11.8 3.3 6.4 1.0 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 ORX65613.1 - 5.2 7.4 12.8 0.43 10.9 7.3 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Methyltransf_10 PF05971.12 ORX65614.1 - 3.6e-63 213.7 0.0 5e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_31 PF13847.6 ORX65614.1 - 0.00067 19.5 0.1 0.0014 18.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX65614.1 - 0.00083 18.9 0.0 0.0018 17.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ORX65614.1 - 0.001 18.5 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ORX65614.1 - 0.002 18.8 0.0 0.0058 17.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX65614.1 - 0.0092 15.9 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX65614.1 - 0.036 13.4 0.0 0.074 12.4 0.0 1.5 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX65614.1 - 0.055 14.1 0.0 0.27 11.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain UPF0020 PF01170.18 ORX65614.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TMEM135_C_rich PF15982.5 ORX65615.1 - 9.1e-10 39.3 0.4 1.4e-09 38.6 0.4 1.3 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.19 ORX65615.1 - 0.15 12.4 0.5 0.4 11.1 0.2 1.9 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family F-box-like PF12937.7 ORX65616.1 - 0.002 18.0 0.0 0.017 15.0 0.0 2.6 2 0 0 2 2 2 1 F-box-like RRM_1 PF00076.22 ORX65617.1 - 1.1e-23 82.9 0.0 1.2e-10 41.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nramp PF01566.18 ORX65617.1 - 2.5e-16 59.6 0.1 7.1e-13 48.3 0.1 2.3 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein RBM39linker PF15519.6 ORX65617.1 - 3.9e-07 31.1 0.0 1.4e-06 29.3 0.0 2.0 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein Nup35_RRM_2 PF14605.6 ORX65617.1 - 0.0098 15.9 0.2 0.98 9.5 0.0 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif YfkB PF08756.10 ORX65618.1 - 0.021 14.6 0.2 0.19 11.5 0.0 2.0 2 0 0 2 2 2 0 YfkB-like domain SPT6_acidic PF14632.6 ORX65619.1 - 0.011 16.3 16.5 0.046 14.3 16.5 2.0 1 1 0 1 1 1 0 Acidic N-terminal SPT6 Spt5_N PF11942.8 ORX65619.1 - 0.018 16.0 6.3 0.018 16.0 6.3 1.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Transferase PF02458.15 ORX65620.1 - 8.4e-21 74.1 0.0 1.1e-18 67.2 0.0 2.7 1 1 0 1 1 1 1 Transferase family DJ-1_PfpI PF01965.24 ORX65621.1 - 1.2e-07 31.7 0.0 3e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ORX65621.1 - 0.00058 19.6 0.0 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 ThiJ/PfpI family-like CorA PF01544.18 ORX65622.1 - 4.5e-40 137.8 1.0 5.8e-40 137.4 1.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Abhydrolase_1 PF00561.20 ORX65623.1 - 4.6e-06 26.5 0.1 1.6e-05 24.7 0.1 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX65623.1 - 3.5e-05 24.5 0.2 8.6e-05 23.2 0.2 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX65623.1 - 0.00034 19.9 0.0 0.00054 19.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CorA PF01544.18 ORX65624.1 - 4.6e-33 114.8 0.0 5e-17 62.2 0.0 2.3 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Pmp3 PF01679.17 ORX65625.1 - 2.4e-23 82.1 6.0 2.6e-23 81.9 6.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator CHCH PF06747.13 ORX65626.1 - 3.2e-05 23.9 4.4 0.0001 22.4 4.4 1.9 1 1 0 1 1 1 1 CHCH domain CX9C PF16860.5 ORX65626.1 - 0.0067 16.4 1.7 0.0067 16.4 1.7 2.0 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Chromo PF00385.24 ORX65627.1 - 0.0017 18.2 0.0 0.0045 16.9 0.0 1.6 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-C2H2 PF00096.26 ORX65628.1 - 2.9e-34 115.6 77.6 4.2e-06 26.9 2.9 10.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX65628.1 - 3.6e-23 80.3 75.6 1.9e-05 25.1 1.6 10.1 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX65628.1 - 5.1e-21 74.1 67.2 3.9e-06 27.0 2.8 10.0 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX65628.1 - 0.0031 17.5 5.8 0.017 15.1 1.3 8.2 10 0 0 10 10 9 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX65628.1 - 0.0037 17.5 35.0 0.0081 16.4 0.8 7.4 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 ORX65628.1 - 0.009 15.9 3.8 0.009 15.9 3.8 4.6 3 1 1 4 4 4 1 SprT-like zinc ribbon domain zf-met PF12874.7 ORX65628.1 - 0.018 15.4 4.4 0.068 13.6 0.7 7.1 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf_Hakai PF18408.1 ORX65628.1 - 0.052 13.3 0.0 0.052 13.3 0.0 6.7 8 0 0 8 8 8 0 C2H2 Hakai zinc finger domain FOXP-CC PF16159.5 ORX65628.1 - 2.2 8.9 30.9 0.81 10.4 0.5 6.6 3 2 4 7 7 7 0 FOXP coiled-coil domain zf-DNA_Pol PF08996.10 ORX65628.1 - 3 7.5 18.1 1.5 8.5 0.9 3.8 1 1 2 3 3 3 0 DNA Polymerase alpha zinc finger zf_UBZ PF18439.1 ORX65628.1 - 3.7 7.2 15.1 21 4.8 1.3 5.7 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Spt46 PF17734.1 ORX65628.1 - 7.2 6.3 16.0 2.4 7.9 1.0 3.4 2 1 2 4 4 4 0 Spermatogenesis-associated protein 46 Gtr1_RagA PF04670.12 ORX65629.1 - 3.5e-38 131.3 0.0 5e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX65629.1 - 0.00041 19.8 0.0 0.00088 18.7 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ORX65629.1 - 0.012 15.1 0.0 0.039 13.4 0.0 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 ORX65629.1 - 0.049 14.1 0.0 0.16 12.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX65629.1 - 0.087 12.9 0.0 0.29 11.2 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase Glyco_transf_15 PF01793.16 ORX65630.1 - 2.3e-112 375.4 10.8 2.8e-112 375.2 10.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4363 PF14276.6 ORX65630.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) CorA PF01544.18 ORX65631.1 - 2.5e-34 118.9 0.5 3.3e-34 118.6 0.5 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Abhydrolase_3 PF07859.13 ORX65633.1 - 9.5e-47 159.6 0.0 1.3e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX65633.1 - 7.8e-09 34.9 0.0 1.3e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 ORX65633.1 - 0.029 15.0 0.2 0.049 14.2 0.2 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family BAAT_C PF08840.11 ORX65633.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal COesterase PF00135.28 ORX65633.1 - 0.1 11.4 0.6 1.2 7.9 0.1 2.0 2 0 0 2 2 2 0 Carboxylesterase family PGAP1 PF07819.13 ORX65633.1 - 0.11 12.2 0.0 0.29 10.8 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein Hydrolase_4 PF12146.8 ORX65633.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Glyco_transf_15 PF01793.16 ORX65634.1 - 1.8e-22 80.0 4.8 3.9e-16 59.2 0.2 2.0 1 1 1 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase Pkinase PF00069.25 ORX65635.1 - 1.5e-65 221.2 0.0 2e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65635.1 - 9.9e-34 116.8 0.0 1.6e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX65635.1 - 0.00019 22.1 0.0 0.00066 20.3 0.1 1.9 2 1 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 ORX65635.1 - 0.0022 17.4 0.0 0.17 11.2 0.0 2.7 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX65635.1 - 0.032 13.6 0.0 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 ORX65635.1 - 0.074 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nab1 PF04902.12 ORX65635.1 - 0.076 13.4 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Conserved region in Nab1 CLPTM1 PF05602.12 ORX65636.1 - 1.7e-107 360.2 0.4 2.4e-107 359.6 0.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ORX65636.1 - 0.00025 20.8 0.3 0.0086 15.8 0.1 2.5 2 0 0 2 2 2 1 PQ loop repeat DUF1681 PF07933.14 ORX65637.1 - 9e-38 129.3 0.0 3.2e-37 127.5 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1681) Aa_trans PF01490.18 ORX65638.1 - 2.9e-43 148.1 32.5 4.2e-43 147.6 32.5 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SAT PF16073.5 ORX65651.1 - 5.6e-05 23.0 0.0 8.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ORX65651.1 - 0.0003 20.8 3.0 0.0021 18.1 1.3 2.5 2 1 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta Phage_XkdX PF09693.10 ORX65651.1 - 0.12 12.5 0.2 0.74 9.9 0.1 2.2 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) Biotin_lipoyl PF00364.22 ORX65653.1 - 1.1e-17 63.6 2.1 1.7e-17 63.0 2.1 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme PCC_BT PF18140.1 ORX65653.1 - 7.4e-13 49.0 0.0 1.4e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain HlyD_3 PF13437.6 ORX65653.1 - 3.1e-07 31.0 1.0 0.036 14.8 0.3 2.5 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 ORX65653.1 - 4.7e-07 29.5 0.5 0.014 15.2 0.0 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_D23 PF16576.5 ORX65653.1 - 3e-05 23.3 0.2 0.053 12.7 0.1 2.4 2 1 1 3 3 3 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 ORX65653.1 - 0.0016 18.3 0.2 0.0026 17.7 0.2 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain PASTA PF03793.19 ORX65653.1 - 0.025 14.4 0.3 3.6 7.5 0.1 2.3 2 0 0 2 2 2 0 PASTA domain NQRA PF05896.11 ORX65653.1 - 0.031 13.7 0.6 0.051 13.0 0.5 1.5 1 1 1 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DUF2118 PF09891.9 ORX65653.1 - 0.073 13.0 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) CPSase_L_D2 PF02786.17 ORX65654.1 - 1.1e-76 257.1 0.0 1.4e-76 256.6 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 ORX65654.1 - 1.1e-31 109.1 0.0 1.9e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ORX65654.1 - 1.4e-10 41.1 0.0 2.9e-10 40.0 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX65654.1 - 9.4e-08 31.8 0.0 1.3e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ORX65654.1 - 0.00011 22.3 0.0 0.00016 21.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ORX65654.1 - 0.00042 20.0 0.0 0.00084 19.0 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 ORX65654.1 - 0.0066 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ORX65654.1 - 0.0072 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain SLX9 PF15341.6 ORX65656.1 - 3.9e-18 66.1 11.4 5.8e-18 65.6 11.4 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 AhpC-TSA PF00578.21 ORX65657.1 - 0.15 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Glyco_transf_15 PF01793.16 ORX65658.1 - 1.8e-106 356.1 0.6 2.3e-106 355.7 0.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DNA_topoisoIV PF00521.20 ORX65658.1 - 0.2 10.5 0.0 0.35 9.7 0.0 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A PseudoU_synth_2 PF00849.22 ORX65660.1 - 1e-22 80.9 0.0 4.3e-21 75.6 0.0 2.1 1 1 0 1 1 1 1 RNA pseudouridylate synthase DUF4477 PF14780.6 ORX65661.1 - 8.9e-14 51.6 2.2 1.3e-13 51.0 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) Myotub-related PF06602.14 ORX65662.1 - 2.8e-106 355.4 0.0 3.4e-106 355.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ORX65662.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 ORX65662.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Ferritin PF00210.24 ORX65662.1 - 0.11 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Ferritin-like domain RRM_1 PF00076.22 ORX65663.1 - 1.1e-38 130.9 0.0 3e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX65663.1 - 1.3e-06 28.4 0.0 0.00023 21.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 ORX65663.1 - 8.6e-05 22.1 0.0 0.052 13.1 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 ORX65663.1 - 0.012 15.3 0.0 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_occluded PF16842.5 ORX65663.1 - 0.041 13.7 0.0 0.24 11.3 0.0 2.1 2 1 0 2 2 2 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 ORX65663.1 - 0.053 13.6 0.1 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 IF-2B PF01008.17 ORX65664.1 - 5.3e-50 170.2 0.3 1e-49 169.3 0.3 1.5 1 1 0 1 1 1 1 Initiation factor 2 subunit family GSIII_N PF12437.8 ORX65665.1 - 3.2e-59 199.2 0.1 5.3e-59 198.5 0.1 1.4 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 ORX65665.1 - 1.9e-37 127.7 0.6 5.1e-37 126.3 0.3 1.9 2 0 0 2 2 2 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 ORX65665.1 - 1.2e-20 73.8 0.0 2.6e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain RasGAP PF00616.19 ORX65666.1 - 1.8e-57 194.4 0.3 4.3e-57 193.2 0.3 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX65666.1 - 1.8e-38 131.8 0.6 1.8e-38 131.8 0.6 2.5 2 0 0 2 2 2 1 RasGAP C-terminus CH PF00307.31 ORX65666.1 - 1.2e-15 57.7 0.0 3.6e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.27 ORX65666.1 - 2.4e-12 45.5 12.3 0.0063 16.2 0.1 5.4 4 0 0 4 4 4 4 IQ calmodulin-binding motif CAMSAP_CH PF11971.8 ORX65666.1 - 0.005 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain MFS_1 PF07690.16 ORX65667.1 - 1.6e-25 89.8 27.2 3.7e-23 82.0 6.2 3.2 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX65667.1 - 2.7e-05 23.2 3.1 2.7e-05 23.2 3.1 2.6 2 2 0 2 2 2 1 Sugar (and other) transporter bZIP_1 PF00170.21 ORX65668.1 - 2.1e-10 40.5 10.0 2.7e-10 40.2 10.0 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX65668.1 - 5e-07 29.7 12.5 8.2e-07 29.0 12.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX65668.1 - 0.0012 19.4 7.7 0.0015 19.0 7.7 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor Phlebovirus_NSM PF07246.11 ORX65668.1 - 0.25 10.7 1.6 0.29 10.5 1.6 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Aft1_HRA PF11786.8 ORX65669.1 - 5e-07 30.0 7.4 5e-07 30.0 7.4 2.5 2 1 0 2 2 2 1 Aft1 HRA domain Aft1_OSA PF11785.8 ORX65669.1 - 2.7e-05 24.5 0.1 2.7e-05 24.5 0.1 2.9 4 0 0 4 4 4 1 Aft1 osmotic stress response (OSM) domain zf-B_box PF00643.24 ORX65672.1 - 0.00011 22.3 2.5 0.00018 21.6 2.5 1.3 1 0 0 1 1 1 1 B-box zinc finger Tektin PF03148.14 ORX65672.1 - 0.18 10.5 5.4 0.11 11.3 3.0 1.9 2 0 0 2 2 2 0 Tektin family AAA_13 PF13166.6 ORX65672.1 - 0.63 8.6 2.3 1 7.9 2.3 1.2 1 0 0 1 1 1 0 AAA domain Glyco_transf_15 PF01793.16 ORX65673.1 - 1.8e-105 352.8 1.0 2.1e-105 352.6 1.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase E1-E2_ATPase PF00122.20 ORX65674.1 - 5.2e-27 94.5 0.8 1.1e-26 93.5 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX65674.1 - 8.1e-09 36.1 2.0 0.0016 18.8 0.8 3.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX65674.1 - 0.00027 20.6 0.1 0.0013 18.4 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX65674.1 - 0.0051 16.9 0.0 0.042 13.9 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Peptidase_M49 PF03571.15 ORX65675.1 - 2.5e-09 36.1 0.4 3.9e-07 28.8 0.1 2.5 3 0 0 3 3 3 2 Peptidase family M49 MPTase-PolyVal PF18818.1 ORX65675.1 - 0.073 13.1 0.6 0.18 11.9 0.1 2.0 2 0 0 2 2 2 0 Metallopeptidase superfamily domain Cation_ATPase_C PF00689.21 ORX65676.1 - 1.2e-33 116.4 6.2 1.2e-33 116.4 6.2 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ORX65676.1 - 3e-31 108.3 1.4 8.6e-31 106.9 0.1 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX65676.1 - 7.6e-12 46.0 0.0 9e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX65676.1 - 3.1e-06 27.2 0.0 5.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.7 ORX65676.1 - 0.12 12.8 0.0 25 5.2 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Ibs_toxin PF13956.6 ORX65676.1 - 0.17 11.9 1.8 0.51 10.4 1.8 1.8 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Phostensin_N PF13916.6 ORX65678.1 - 2.9 8.3 8.4 34 4.9 0.0 3.2 3 0 0 3 3 3 0 PP1-regulatory protein, Phostensin N-terminal Myb_DNA-binding PF00249.31 ORX65679.1 - 2.2e-35 120.6 4.2 9.5e-13 48.1 0.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX65679.1 - 1.7e-28 98.6 1.1 2.9e-13 49.9 0.3 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 ORX65679.1 - 0.0029 17.6 0.0 3.2 7.8 0.0 2.7 2 1 0 2 2 2 2 SLIDE Rap1_C PF11626.8 ORX65679.1 - 0.0052 16.8 4.8 3.2 7.9 0.1 3.6 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Ada3 PF10198.9 ORX65679.1 - 0.17 12.0 0.6 0.48 10.6 0.0 2.1 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 DUF2309 PF10070.9 ORX65680.1 - 0.016 13.6 1.9 0.018 13.4 1.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) PigN PF04987.14 ORX65680.1 - 0.55 9.0 3.8 1.1 8.1 3.8 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) PA26 PF04636.13 ORX65680.1 - 0.97 8.3 3.9 1.5 7.7 3.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Ndc1_Nup PF09531.10 ORX65680.1 - 4.8 5.7 11.8 8.2 5.0 11.8 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 ORX65680.1 - 6.5 6.6 19.9 10 6.0 19.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sec39 PF08314.11 ORX65681.1 - 1.1e-14 53.9 0.0 4.7e-14 51.8 0.0 1.8 1 1 0 1 1 1 1 Secretory pathway protein Sec39 DSPc PF00782.20 ORX65686.1 - 9.8e-35 119.3 0.0 1.1e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX65686.1 - 0.00038 20.1 0.0 0.00044 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX65686.1 - 0.0013 18.9 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 ORX65686.1 - 0.031 14.6 0.0 0.042 14.2 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain Cpn60_TCP1 PF00118.24 ORX65688.1 - 1.4e-160 535.2 0.7 1.6e-160 535.0 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 ORX65689.1 - 8.6e-35 118.2 12.0 3e-05 24.7 0.1 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65689.1 - 4.6e-19 68.5 1.2 0.00017 21.8 0.1 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX65689.1 - 5.1e-11 42.4 0.0 5.4e-07 29.2 0.0 3.2 2 2 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 ORX65689.1 - 1.3e-07 31.7 0.4 0.0092 15.9 0.1 2.9 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX65689.1 - 4.8e-05 22.5 0.0 0.079 11.9 0.0 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX65689.1 - 0.13 10.9 2.1 2 6.9 0.3 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 HEAT PF02985.22 ORX65690.1 - 9.8e-45 146.7 21.2 0.00044 20.3 0.0 13.4 13 0 0 13 13 13 11 HEAT repeat HEAT_2 PF13646.6 ORX65690.1 - 7.9e-37 125.5 7.5 3.7e-11 43.3 0.0 7.8 3 3 4 7 7 7 7 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX65690.1 - 1.9e-15 57.2 0.7 6e-06 26.8 0.3 6.4 3 3 3 6 6 6 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ORX65690.1 - 9.8e-15 54.1 2.4 5.3e-10 38.5 0.3 2.4 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 ORX65690.1 - 2.6e-12 47.1 2.4 0.0013 18.8 0.7 4.8 3 2 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX65690.1 - 6.9e-07 29.6 16.1 0.013 16.0 0.1 8.9 8 3 4 12 12 12 2 HEAT-like repeat CLASP_N PF12348.8 ORX65690.1 - 5.4e-06 26.1 0.1 2.5 7.6 0.0 4.8 3 2 2 6 6 6 2 CLASP N terminal DUF1981 PF09324.10 ORX65690.1 - 0.078 12.8 0.1 19 5.2 0.0 4.0 3 2 1 4 4 4 0 Domain of unknown function (DUF1981) Pkinase PF00069.25 ORX65691.1 - 1.7e-68 230.9 0.0 1.9e-68 230.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65691.1 - 8.9e-31 107.1 0.0 1.7e-30 106.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX65691.1 - 6e-05 22.5 0.1 0.011 15.1 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 ORX65691.1 - 0.0031 17.5 0.1 0.07 13.0 0.1 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX65691.1 - 0.011 15.3 0.1 0.016 14.8 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 ORX65691.1 - 0.05 12.6 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Cerato-platanin PF07249.12 ORX65692.1 - 0.00019 21.5 0.1 0.00039 20.5 0.1 1.5 1 0 0 1 1 1 1 Cerato-platanin Pkinase PF00069.25 ORX65693.1 - 7.6e-67 225.4 0.0 8.8e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65693.1 - 5.2e-41 140.6 0.0 6.4e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX65693.1 - 0.00048 19.0 0.0 0.00076 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX65693.1 - 0.0071 15.7 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX65693.1 - 0.025 13.5 0.0 0.073 12.0 0.0 1.8 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 ORX65693.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RasGAP PF00616.19 ORX65695.1 - 4.5e-19 69.0 0.0 4.8e-12 46.0 0.0 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 ORX65695.1 - 2.2e-09 37.5 0.0 4.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain PAS_3 PF08447.12 ORX65697.1 - 0.054 13.8 0.0 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 PAS fold PAS PF00989.25 ORX65697.1 - 0.061 13.3 0.0 0.39 10.7 0.0 2.3 3 0 0 3 3 3 0 PAS fold ING PF12998.7 ORX65698.1 - 9.9e-25 87.1 2.5 1.8e-24 86.3 2.5 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX65698.1 - 9.3e-06 25.4 9.0 1.6e-05 24.7 9.0 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX65698.1 - 0.04 13.5 1.9 0.067 12.8 1.9 1.4 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 ORX65698.1 - 0.15 12.3 3.3 0.36 11.1 3.3 1.6 1 1 0 1 1 1 0 PHD-like zinc-binding domain RAP1 PF07218.11 ORX65698.1 - 0.68 8.1 4.0 0.97 7.6 4.0 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ribosomal_L10 PF00466.20 ORX65699.1 - 2.4e-05 24.4 0.0 4.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Abhydrolase_1 PF00561.20 ORX65700.1 - 2.5e-08 33.9 0.0 3.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX65700.1 - 1.4e-05 25.8 0.0 2.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX65700.1 - 0.00039 19.8 0.0 0.00052 19.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 ORX65700.1 - 0.0028 17.3 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 ORX65700.1 - 0.043 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 ORX65700.1 - 0.077 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Prok-E2_A PF14457.6 ORX65700.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family A DUF2048 PF09752.9 ORX65700.1 - 0.15 11.1 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Palm_thioest PF02089.15 ORX65700.1 - 0.15 11.9 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF1729 PF08354.10 ORX65702.1 - 2.7e-73 246.9 0.0 4.3e-73 246.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX65702.1 - 5.6e-47 160.1 0.0 9.5e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX65702.1 - 4.8e-43 147.9 0.0 1.1e-38 133.6 0.0 3.8 3 1 1 4 4 4 2 Acyl transferase domain FAS_I_H PF18314.1 ORX65702.1 - 9.3e-39 133.2 0.3 1.5e-38 132.5 0.3 1.3 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain FAS_meander PF17951.1 ORX65702.1 - 1.1e-20 73.9 0.0 2.2e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX65702.1 - 1.9e-19 70.3 0.0 6e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 ORX65702.1 - 4.5e-05 23.0 0.0 0.00014 21.4 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 ORX65702.1 - 9e-05 22.5 0.0 0.00032 20.7 0.0 2.0 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta GDP_Man_Dehyd PF16363.5 ORX65702.1 - 0.1 11.9 0.1 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ketoacyl-synt PF00109.26 ORX65703.1 - 5.3e-19 68.8 0.1 8.4e-19 68.1 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 ORX65703.1 - 0.012 15.0 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX65704.1 - 2.7e-17 62.9 0.0 3.9e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Hydrolase_4 PF12146.8 ORX65705.1 - 0.0075 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX65705.1 - 0.018 14.7 0.0 0.051 13.2 0.0 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold LIP PF03583.14 ORX65705.1 - 0.097 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Secretory lipase Peptidase_S9 PF00326.21 ORX65705.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF1729 PF08354.10 ORX65709.1 - 8e-58 196.0 0.0 5.8e-38 130.7 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX65709.1 - 2.1e-51 174.5 0.1 6e-51 173.0 0.1 1.9 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX65709.1 - 2.8e-42 144.7 0.1 7.7e-42 143.2 0.1 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Acyl_transf_1 PF00698.21 ORX65709.1 - 1.1e-34 120.4 1.7 1.1e-33 117.1 0.3 2.7 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.19 ORX65709.1 - 1.8e-25 88.9 0.0 5.1e-25 87.4 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX65709.1 - 2.1e-25 89.3 0.0 5.8e-25 87.8 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX65709.1 - 1.1e-18 67.9 0.0 2.4e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX65709.1 - 1.7e-17 63.5 0.0 7.4e-15 55.0 0.0 3.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 ORX65709.1 - 2.4e-17 63.4 0.3 5.3e-17 62.2 0.3 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MCD_N PF17408.2 ORX65709.1 - 0.073 13.2 0.1 20 5.4 0.0 3.0 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain Prp19 PF08606.11 ORX65710.1 - 2e-35 120.6 2.6 4e-35 119.6 2.6 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 ORX65710.1 - 7e-18 64.7 6.3 0.0029 18.4 0.0 6.5 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65710.1 - 3e-11 43.4 1.9 9.7e-07 29.0 0.0 4.7 1 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain FlaE PF07559.14 ORX65710.1 - 0.0027 18.3 1.0 0.098 13.2 0.1 2.8 2 1 1 3 3 3 1 Flagellar basal body protein FlaE eIF2A PF08662.11 ORX65710.1 - 0.0043 16.9 0.2 0.17 11.7 0.1 2.8 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX65710.1 - 0.015 14.2 0.5 0.82 8.6 0.1 2.6 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Utp8 PF10395.9 ORX65710.1 - 0.034 12.6 0.0 0.053 12.0 0.0 1.2 1 0 0 1 1 1 0 Utp8 family U-box PF04564.15 ORX65710.1 - 0.036 14.2 0.0 0.077 13.2 0.0 1.5 1 0 0 1 1 1 0 U-box domain WD40_like PF17005.5 ORX65710.1 - 0.085 12.2 0.0 0.66 9.2 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain FixH PF05751.11 ORX65710.1 - 0.13 12.3 1.5 2.3 8.2 0.1 3.1 3 0 0 3 3 3 0 FixH DUF1635 PF07795.11 ORX65710.1 - 0.16 11.8 2.5 0.18 11.6 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF3450 PF11932.8 ORX65710.1 - 0.19 11.0 7.4 0.069 12.5 3.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) YlqD PF11068.8 ORX65710.1 - 0.5 10.7 6.2 0.34 11.3 2.2 2.4 2 0 0 2 2 2 0 YlqD protein Ribosomal_L4 PF00573.22 ORX65711.1 - 7.5e-29 100.8 2.6 1.2e-28 100.2 2.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ORX65711.1 - 3.4e-27 94.3 0.6 3.4e-27 94.3 0.6 2.4 2 1 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Gpr1_Fun34_YaaH PF01184.19 ORX65712.1 - 2.4e-37 128.6 6.0 2.8e-37 128.3 6.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ESSS PF10183.9 ORX65713.1 - 0.0076 16.5 1.1 0.089 13.0 1.9 1.9 2 0 0 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ribosomal_L6 PF00347.23 ORX65714.1 - 2.3e-20 73.0 4.6 2.7e-14 53.6 1.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 JAB PF01398.21 ORX65715.1 - 1.2e-12 47.8 0.0 2.5e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.13 ORX65715.1 - 0.044 13.8 0.0 0.09 12.8 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) PilO PF04350.13 ORX65715.1 - 0.27 11.4 1.0 0.73 10.0 0.5 1.9 2 0 0 2 2 2 0 Pilus assembly protein, PilO OPT PF03169.15 ORX65716.1 - 7.7e-132 441.0 47.5 1.1e-131 440.5 47.5 1.2 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Yae1_N PF09811.9 ORX65718.1 - 5.5e-09 35.6 0.7 7.5e-09 35.2 0.7 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal EVE PF01878.18 ORX65720.1 - 4.9e-52 175.8 0.1 6e-52 175.5 0.1 1.1 1 0 0 1 1 1 1 EVE domain 7tm_3 PF00003.22 ORX65721.1 - 5.2e-07 29.6 22.5 7.5e-07 29.1 22.5 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX65722.1 - 3e-06 27.1 25.4 4.3e-06 26.6 25.4 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4666 PF15697.5 ORX65724.1 - 0.092 13.4 0.2 0.1 13.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) PIG-S PF10510.9 ORX65725.1 - 6.8e-116 388.1 0.5 8.1e-116 387.9 0.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein AAA_33 PF13671.6 ORX65726.1 - 2e-19 70.1 0.1 4.4e-11 43.1 0.1 2.0 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 ORX65726.1 - 2.6e-05 24.8 0.2 0.014 15.9 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX65726.1 - 7.3e-05 23.1 0.0 9.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 ORX65726.1 - 7.5e-05 22.9 0.0 9.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_17 PF13207.6 ORX65726.1 - 9.1e-05 22.9 0.8 0.17 12.3 0.1 2.1 1 1 1 2 2 2 2 AAA domain AAA_28 PF13521.6 ORX65726.1 - 0.00013 22.2 0.0 0.00017 21.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX65726.1 - 0.00085 19.8 0.0 0.0009 19.7 0.0 1.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 ORX65726.1 - 0.0028 17.2 0.2 0.24 10.8 0.1 2.0 1 1 1 2 2 2 1 Chromatin associated protein KTI12 AAA_5 PF07728.14 ORX65726.1 - 0.0056 16.7 0.1 0.017 15.2 0.1 1.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 ORX65726.1 - 0.0063 16.2 0.1 0.22 11.2 0.0 2.6 1 1 1 2 2 2 1 Thymidylate kinase NACHT PF05729.12 ORX65726.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ORX65726.1 - 0.016 15.6 0.0 0.022 15.1 0.0 1.2 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 ORX65726.1 - 0.019 15.3 0.0 0.02 15.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ORX65726.1 - 0.041 13.3 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ORX65726.1 - 0.059 12.6 0.1 0.52 9.5 0.0 2.0 1 1 1 2 2 2 0 Zeta toxin AAA_24 PF13479.6 ORX65726.1 - 0.072 12.8 0.0 0.081 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ORX65726.1 - 0.094 12.0 0.1 0.3 10.4 0.0 1.7 1 1 1 2 2 2 0 6-phosphofructo-2-kinase Sigma54_activ_2 PF14532.6 ORX65726.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain SKI PF01202.22 ORX65726.1 - 0.12 12.5 0.0 4.2 7.5 0.1 2.2 1 1 0 2 2 2 0 Shikimate kinase dNK PF01712.19 ORX65726.1 - 0.18 11.6 0.0 17 5.2 0.0 2.6 1 1 2 3 3 3 0 Deoxynucleoside kinase Malic_M PF03949.15 ORX65727.1 - 6.9e-80 268.0 0.0 1e-79 267.5 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX65727.1 - 7.3e-59 198.6 0.0 1.1e-58 198.0 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain MFS_1 PF07690.16 ORX65729.1 - 1.1e-25 90.4 47.1 2.1e-20 73.0 27.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3290 PF11694.8 ORX65729.1 - 0.035 14.1 0.3 4 7.4 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) POT1 PF02765.17 ORX65730.1 - 1.2e-09 38.1 0.0 2.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.5 ORX65730.1 - 3.3e-06 27.0 0.1 0.00073 19.4 0.1 2.5 1 1 0 1 1 1 1 ssDNA-binding domain of telomere protection protein Clat_adaptor_s PF01217.20 ORX65731.1 - 2.6e-56 189.5 3.4 3e-56 189.3 3.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_transf_92 PF01697.27 ORX65731.1 - 0.019 14.6 0.1 0.025 14.2 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 92 Peptidase_M20 PF01546.28 ORX65732.1 - 6.9e-27 94.5 0.0 1.1e-26 93.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ORX65732.1 - 2.8e-10 40.1 0.0 5.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 ORX65732.1 - 1.2e-09 38.6 23.2 0.002 18.9 0.5 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat WD40_like PF17005.5 ORX65732.1 - 0.00037 19.9 0.0 0.67 9.2 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 ORX65732.1 - 0.002 18.4 0.5 1.3 9.4 0.0 4.3 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ORX65732.1 - 0.0047 17.4 10.1 12 6.5 0.1 5.9 6 0 0 6 6 6 2 PQQ-like domain AAA PF00004.29 ORX65733.1 - 1.7e-83 277.7 0.0 3.9e-42 143.8 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX65733.1 - 8.5e-34 115.1 2.3 3e-16 58.9 0.2 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX65733.1 - 2.6e-13 50.7 0.2 2.1e-06 28.2 0.2 3.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 ORX65733.1 - 3.1e-13 49.9 0.3 2.1e-06 27.8 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX65733.1 - 1.6e-12 47.9 0.0 1.1e-05 25.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX65733.1 - 2e-12 47.1 0.5 4.4e-05 23.3 0.1 3.2 2 2 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX65733.1 - 1.2e-08 35.3 2.3 0.0056 16.9 0.3 4.3 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX65733.1 - 2.1e-07 31.1 0.0 0.028 14.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ORX65733.1 - 2.3e-07 31.1 0.4 0.047 13.9 0.0 3.3 3 1 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 ORX65733.1 - 6.2e-07 29.8 0.0 0.023 15.1 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 ORX65733.1 - 1.5e-06 28.3 0.0 0.00032 20.7 0.0 2.6 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_3 PF07726.11 ORX65733.1 - 2.6e-06 27.3 1.1 0.0062 16.4 0.0 3.0 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ORX65733.1 - 2.8e-06 27.4 0.0 0.11 12.4 0.0 3.3 2 2 0 3 3 3 2 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ORX65733.1 - 8.5e-06 26.3 0.0 0.13 12.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Viral_helicase1 PF01443.18 ORX65733.1 - 1.4e-05 25.0 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.18 ORX65733.1 - 1.7e-05 24.8 0.0 0.0014 18.5 0.0 2.9 2 2 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.12 ORX65733.1 - 2.3e-05 24.3 0.1 0.059 13.3 0.0 3.2 2 1 1 3 3 3 1 NACHT domain TIP49 PF06068.13 ORX65733.1 - 5.9e-05 22.4 0.0 0.091 11.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain TsaE PF02367.17 ORX65733.1 - 7.2e-05 22.8 0.0 0.074 13.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ORX65733.1 - 9.5e-05 22.2 0.0 0.0045 16.7 0.0 2.7 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 ORX65733.1 - 0.00013 21.6 1.1 0.46 10.0 0.1 3.8 2 2 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX65733.1 - 0.00013 21.8 0.0 0.044 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX65733.1 - 0.00017 21.5 1.2 0.67 9.9 0.1 3.0 2 2 1 3 3 3 2 NTPase AAA_7 PF12775.7 ORX65733.1 - 0.00018 21.1 0.1 0.23 11.0 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_11 PF13086.6 ORX65733.1 - 0.00018 21.4 0.1 0.26 11.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 ORX65733.1 - 0.00038 20.4 0.0 0.13 12.3 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 ORX65733.1 - 0.00041 19.6 0.0 0.33 10.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 ORX65733.1 - 0.00073 19.0 0.3 1.5 8.2 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.14 ORX65733.1 - 0.00094 18.5 0.0 2.5 7.2 0.0 3.1 3 1 0 3 3 3 2 KAP family P-loop domain AFG1_ATPase PF03969.16 ORX65733.1 - 0.0011 18.0 0.0 0.075 11.9 0.0 2.5 2 0 0 2 2 2 1 AFG1-like ATPase AAA_28 PF13521.6 ORX65733.1 - 0.0022 18.3 0.6 0.97 9.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX65733.1 - 0.0031 18.1 0.0 0.22 12.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX65733.1 - 0.0048 17.2 2.4 0.66 10.3 0.2 3.1 2 2 1 3 3 3 1 AAA domain AAA_30 PF13604.6 ORX65733.1 - 0.0054 16.5 0.1 1.1 8.9 0.1 3.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX65733.1 - 0.0068 15.7 0.0 0.63 9.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.6 ORX65733.1 - 0.0089 16.5 0.7 5.7 7.4 0.1 2.9 2 1 0 2 2 2 0 AAA domain MCM PF00493.23 ORX65733.1 - 0.011 14.9 0.0 3.7 6.6 0.0 2.5 2 1 0 2 2 2 0 MCM P-loop domain NB-ARC PF00931.22 ORX65733.1 - 0.011 14.9 0.0 1.8 7.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.26 ORX65733.1 - 0.018 14.8 0.3 12 5.5 0.0 3.9 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 ORX65733.1 - 0.036 13.8 0.0 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 ORX65733.1 - 0.045 13.2 0.1 4.6 6.6 0.0 3.4 3 1 1 4 4 4 0 Bacterial TniB protein RsgA_GTPase PF03193.16 ORX65733.1 - 0.059 13.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 ORX65733.1 - 0.21 11.8 0.4 6.2 7.1 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 ORX65734.1 - 7.5e-67 219.6 21.9 9.1e-11 42.1 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65734.1 - 4.3e-27 94.2 1.1 1e-05 25.7 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX65734.1 - 5.8e-16 58.2 6.6 0.0027 16.5 0.0 5.0 3 1 3 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX65734.1 - 2.9e-11 43.6 0.2 1.5e-05 25.0 0.0 3.9 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX65734.1 - 2.3e-08 33.4 3.9 0.22 10.4 0.0 4.8 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX65734.1 - 5.5e-07 29.2 0.0 0.0001 21.7 0.0 2.9 1 1 3 4 4 4 2 WD40-like domain RicinB_lectin_2 PF14200.6 ORX65734.1 - 8.4e-07 29.6 3.8 0.007 17.1 0.1 3.1 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like PALB2_WD40 PF16756.5 ORX65734.1 - 2e-06 27.0 5.6 0.041 12.8 0.0 4.9 1 1 4 5 5 5 3 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ORX65734.1 - 0.00011 21.7 0.7 3.1 7.1 0.0 4.0 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Ricin_B_lectin PF00652.22 ORX65734.1 - 0.00026 21.2 2.3 0.014 15.7 0.1 2.9 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 ORX65734.1 - 0.00095 18.8 0.5 0.25 10.9 0.0 3.0 1 1 2 3 3 3 1 Cytolethal distending toxin A/C domain Frtz PF11768.8 ORX65734.1 - 0.0024 16.3 0.1 0.017 13.5 0.0 2.0 1 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 ORX65734.1 - 0.0098 15.0 0.5 0.73 8.8 0.1 2.9 1 1 1 2 2 2 1 Coatomer WD associated region IKI3 PF04762.12 ORX65734.1 - 0.026 12.6 0.2 0.075 11.0 0.1 1.7 1 1 0 1 1 1 0 IKI3 family DUF1513 PF07433.11 ORX65734.1 - 0.027 13.6 0.1 13 4.7 0.0 3.5 1 1 2 4 4 4 0 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 ORX65734.1 - 0.039 12.5 0.0 1.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 ORX65734.1 - 0.14 12.1 2.1 4.2 7.4 0.1 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Hira PF07569.11 ORX65734.1 - 0.3 10.8 4.4 25 4.5 0.0 4.1 2 1 3 5 5 5 0 TUP1-like enhancer of split Y_phosphatase2 PF03162.13 ORX65735.1 - 1.3e-22 80.2 1.0 1.4e-16 60.5 0.1 2.1 1 1 1 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.20 ORX65735.1 - 0.0035 17.1 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ORX65735.1 - 0.0044 17.0 0.0 0.0044 17.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX65735.1 - 0.012 15.2 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ATP-synt_J PF04911.12 ORX65736.1 - 5.5e-15 54.7 0.0 6e-15 54.6 0.0 1.0 1 0 0 1 1 1 1 ATP synthase j chain ABC_tran_CTD PF16326.5 ORX65736.1 - 0.024 14.9 0.0 0.027 14.7 0.0 1.1 1 0 0 1 1 1 0 ABC transporter C-terminal domain GST_N PF02798.20 ORX65737.1 - 0.00055 20.2 0.0 0.0015 18.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX65737.1 - 0.011 15.9 0.1 0.02 15.1 0.1 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MazG PF03819.17 ORX65737.1 - 0.055 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain ISN1 PF06437.11 ORX65738.1 - 6.1e-138 460.2 0.0 6.9e-138 460.0 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase JAB PF01398.21 ORX65739.1 - 3.6e-07 30.2 0.0 5.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ORX65739.1 - 5.5e-05 22.9 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain GATase PF00117.28 ORX65740.1 - 6.5e-38 130.4 0.0 9.7e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 ORX65740.1 - 7.8e-34 116.3 0.4 3.4e-32 111.0 0.4 2.4 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 ORX65740.1 - 4.9e-05 23.2 0.1 0.0089 15.8 0.1 2.2 1 1 0 1 1 1 1 Peptidase C26 7tm_3 PF00003.22 ORX65741.1 - 0.0029 17.3 20.1 0.0044 16.8 20.1 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF3095 PF11294.8 ORX65742.1 - 0.0016 17.5 0.4 0.002 17.2 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3095) 7tm_3 PF00003.22 ORX65743.1 - 1.4e-05 25.0 24.5 2e-05 24.4 24.5 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2157 PF09925.9 ORX65743.1 - 0.74 9.6 5.4 1.7 8.4 1.1 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) 7tm_3 PF00003.22 ORX65744.1 - 2.1e-06 27.6 24.5 3.1e-06 27.1 24.5 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX65745.1 - 1.2e-06 28.4 24.4 1.7e-06 27.9 24.4 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR zf_PR_Knuckle PF18445.1 ORX65746.1 - 0.067 13.0 0.5 0.19 11.6 0.2 1.9 1 1 1 2 2 2 0 PR zinc knuckle motif EVE PF01878.18 ORX65747.1 - 4.9e-52 175.8 0.1 6e-52 175.5 0.1 1.1 1 0 0 1 1 1 1 EVE domain Yae1_N PF09811.9 ORX65749.1 - 4e-09 36.0 0.7 5.4e-09 35.6 0.7 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal OPT PF03169.15 ORX65750.1 - 3.2e-162 541.4 50.1 3.6e-162 541.2 50.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein JAB PF01398.21 ORX65751.1 - 1e-12 48.0 0.0 2.1e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.13 ORX65751.1 - 0.042 13.9 0.0 0.086 12.9 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) PilO PF04350.13 ORX65751.1 - 0.26 11.4 1.0 0.71 10.0 0.5 1.9 2 0 0 2 2 2 0 Pilus assembly protein, PilO Ribosomal_L6 PF00347.23 ORX65752.1 - 2e-30 105.3 7.7 3.4e-15 56.5 0.8 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 ESSS PF10183.9 ORX65753.1 - 0.00016 21.8 0.0 0.0002 21.6 0.0 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Gpr1_Fun34_YaaH PF01184.19 ORX65754.1 - 2.2e-37 128.7 5.7 2.5e-37 128.5 5.7 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Ribosomal_L4 PF00573.22 ORX65755.1 - 2.7e-37 128.3 1.9 4.2e-37 127.7 1.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ORX65755.1 - 4.3e-27 94.0 0.6 4.3e-27 94.0 0.6 2.4 2 1 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Hep_59 PF07052.11 ORX65755.1 - 0.08 13.7 0.0 8.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Prp19 PF08606.11 ORX65756.1 - 4e-35 119.6 2.6 4e-35 119.6 2.6 1.7 2 0 0 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 ORX65756.1 - 9.4e-18 64.3 6.6 0.0029 18.4 0.0 6.5 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65756.1 - 7e-11 42.3 1.5 7.1e-07 29.4 0.0 4.7 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain FlaE PF07559.14 ORX65756.1 - 0.0024 18.4 0.9 0.093 13.3 0.1 2.9 2 1 1 3 3 3 1 Flagellar basal body protein FlaE eIF2A PF08662.11 ORX65756.1 - 0.0049 16.8 0.2 0.17 11.7 0.1 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX65756.1 - 0.016 14.2 0.5 0.61 9.0 0.2 2.6 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein U-box PF04564.15 ORX65756.1 - 0.036 14.2 0.0 0.077 13.2 0.0 1.5 1 0 0 1 1 1 0 U-box domain Utp8 PF10395.9 ORX65756.1 - 0.038 12.5 0.0 0.058 11.9 0.0 1.2 1 0 0 1 1 1 0 Utp8 family WD40_like PF17005.5 ORX65756.1 - 0.085 12.2 0.0 0.68 9.2 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain FixH PF05751.11 ORX65756.1 - 0.13 12.3 1.5 2.3 8.2 0.1 3.1 3 0 0 3 3 3 0 FixH DUF1635 PF07795.11 ORX65756.1 - 0.18 11.6 2.5 0.18 11.6 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF3450 PF11932.8 ORX65756.1 - 0.22 10.8 7.4 0.069 12.5 3.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) YlqD PF11068.8 ORX65756.1 - 0.5 10.7 6.2 0.34 11.3 2.2 2.4 2 0 0 2 2 2 0 YlqD protein DUF1729 PF08354.10 ORX65757.1 - 1.3e-55 188.8 0.0 7.8e-36 123.7 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX65757.1 - 3.3e-51 173.8 0.3 1.1e-50 172.2 0.1 2.1 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX65757.1 - 1.5e-48 166.0 1.8 1.4e-47 162.7 1.0 2.4 2 0 0 2 2 2 1 Acyl transferase domain FAS_I_H PF18314.1 ORX65757.1 - 1.1e-42 146.0 0.0 2.9e-42 144.6 0.0 1.8 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain FAS_meander PF17951.1 ORX65757.1 - 1.1e-25 90.2 0.0 2.6e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 ORX65757.1 - 2.1e-24 85.4 0.0 6.1e-24 83.9 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 ORX65757.1 - 2.1e-19 70.2 0.0 5e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 ORX65757.1 - 2.2e-17 63.5 0.4 5.4e-17 62.2 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX65757.1 - 5.3e-17 61.9 0.0 5.6e-15 55.4 0.0 2.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Pkinase_fungal PF17667.1 ORX65778.1 - 1.7e-10 40.3 0.0 2.3e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX65778.1 - 8.3e-06 25.9 0.1 1e-05 25.6 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 ORX65778.1 - 0.0055 16.1 0.0 0.0061 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain LapA_dom PF06305.11 ORX65779.1 - 0.024 14.4 0.2 0.039 13.8 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2583 PF10762.9 ORX65779.1 - 0.053 13.9 0.0 0.064 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) Say1_Mug180 PF10340.9 ORX65779.1 - 0.071 12.0 0.1 0.078 11.8 0.1 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase HemY_N PF07219.13 ORX65779.1 - 0.16 12.2 0.1 0.22 11.8 0.1 1.2 1 0 0 1 1 1 0 HemY protein N-terminus UCR_UQCRX_QCR9 PF05365.12 ORX65780.1 - 1.6e-14 53.6 4.5 1.9e-14 53.3 4.5 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Tricorn_C1 PF14684.6 ORX65780.1 - 0.0069 16.4 0.4 0.01 15.9 0.4 1.3 1 0 0 1 1 1 1 Tricorn protease C1 domain AalphaY_MDB PF04611.12 ORX65783.1 - 0.045 13.8 0.2 0.095 12.7 0.2 1.6 1 0 0 1 1 1 0 Mating type protein A alpha Y mating type dependent binding region Amelotin PF15757.5 ORX65783.1 - 0.082 12.5 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Amelotin p450 PF00067.22 ORX65784.1 - 1.6e-38 132.6 0.0 4.4e-23 81.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF2847 PF11009.8 ORX65784.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) p450 PF00067.22 ORX65799.1 - 5.7e-58 196.8 0.0 6.9e-58 196.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Delta_lysin PF05372.11 ORX65799.1 - 0.054 12.8 0.1 0.15 11.3 0.1 1.8 1 0 0 1 1 1 0 Delta lysin family Ubie_methyltran PF01209.18 ORX65800.1 - 2.8e-32 111.9 0.0 3.4e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX65800.1 - 9.2e-19 67.9 0.0 1.4e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX65800.1 - 3.9e-17 62.8 0.0 5.8e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX65800.1 - 1.4e-14 54.1 0.0 1.8e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX65800.1 - 2.4e-10 41.0 0.0 3.3e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX65800.1 - 4.6e-09 36.3 0.0 5.9e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 ORX65800.1 - 5.2e-07 29.5 0.0 7.6e-05 22.4 0.0 2.1 1 1 1 2 2 2 2 MraW methylase family Methyltransf_8 PF05148.15 ORX65800.1 - 0.00039 20.4 0.0 0.00079 19.3 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 ORX65800.1 - 0.066 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain UPF0061 PF02696.14 ORX65801.1 - 1.3e-124 416.6 0.0 1.9e-124 416.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Mg_trans_NIPA PF05653.14 ORX65801.1 - 2.3e-26 92.6 22.1 3.1e-16 59.3 8.0 2.9 3 0 0 3 3 3 2 Magnesium transporter NIPA EamA PF00892.20 ORX65801.1 - 1e-05 25.8 8.6 1e-05 25.8 8.6 2.9 3 0 0 3 3 3 1 EamA-like transporter family TMEM234 PF10639.9 ORX65801.1 - 0.015 15.3 2.0 0.044 13.8 0.5 2.5 3 0 0 3 3 3 0 Putative transmembrane family 234 adh_short PF00106.25 ORX65802.1 - 2.6e-13 49.9 0.2 5.4e-12 45.6 0.2 2.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX65802.1 - 1.1e-09 38.2 0.0 0.0003 20.4 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase CLTH PF10607.9 ORX65803.1 - 1.3e-16 60.8 0.0 3e-16 59.6 0.0 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 ORX65803.1 - 8.3e-08 32.1 0.1 1.6e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX65803.1 - 7.9e-05 22.5 0.2 0.00014 21.7 0.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Syntaxin-6_N PF09177.11 ORX65803.1 - 0.00023 21.6 0.9 0.00066 20.2 0.6 1.8 2 0 0 2 2 2 1 Syntaxin 6, N-terminal zf-C3HC4 PF00097.25 ORX65803.1 - 0.0017 18.1 0.2 0.0034 17.2 0.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX65803.1 - 0.0041 17.4 0.3 0.0079 16.5 0.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX65803.1 - 0.0044 16.8 0.7 0.0085 15.9 0.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF883 PF05957.13 ORX65803.1 - 0.011 16.3 0.8 0.011 16.3 0.8 2.0 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF883) zf-C3HC4_4 PF15227.6 ORX65803.1 - 0.03 14.5 0.4 0.087 13.0 0.4 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF3151 PF11349.8 ORX65803.1 - 0.039 14.1 3.6 4 7.5 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3151) HAUS-augmin3 PF14932.6 ORX65803.1 - 0.04 13.5 2.5 0.053 13.1 2.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Prok-RING_4 PF14447.6 ORX65803.1 - 0.051 13.4 3.2 0.2 11.5 3.3 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 TPR_20 PF14561.6 ORX65803.1 - 0.11 12.9 2.6 2.7 8.4 0.5 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-C3HC4_2 PF13923.6 ORX65803.1 - 0.27 11.1 2.9 1.3 8.9 2.9 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FUSC-like PF12805.7 ORX65803.1 - 0.46 9.5 4.2 0.69 8.9 0.3 2.1 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS CPL PF08144.11 ORX65804.1 - 3.3e-21 76.1 2.8 1.3e-14 54.7 0.0 5.7 4 2 2 6 6 6 2 CPL (NUC119) domain PUF PF00806.19 ORX65804.1 - 0.00011 21.6 0.0 0.4 10.5 0.0 4.5 5 0 0 5 5 5 1 Pumilio-family RNA binding repeat DUF2944 PF11161.8 ORX65804.1 - 3 7.7 5.2 6.5 6.6 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2946) adh_short PF00106.25 ORX65805.1 - 2.8e-40 137.9 1.1 2.8e-40 137.9 1.1 1.7 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX65805.1 - 9.7e-34 116.9 4.0 1.2e-33 116.6 4.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX65805.1 - 2.1e-09 37.5 0.6 4.4e-09 36.5 0.6 1.5 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ORX65805.1 - 1.9e-07 30.4 0.1 3e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX65805.1 - 1.6e-05 24.5 1.1 2.2e-05 24.1 0.2 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ORX65805.1 - 0.0012 18.8 1.3 0.002 18.0 0.2 1.8 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ORX65805.1 - 0.0013 18.2 0.1 0.0025 17.3 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 ORX65805.1 - 0.0016 19.0 0.8 0.0087 16.6 0.1 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 ORX65805.1 - 0.0045 16.6 1.0 0.012 15.2 0.4 1.9 2 0 0 2 2 2 1 NmrA-like family DFP PF04127.15 ORX65805.1 - 0.0049 16.7 0.8 0.0097 15.8 0.1 1.7 2 0 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein 2-Hacid_dh_C PF02826.19 ORX65805.1 - 0.017 14.5 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TLD PF07534.16 ORX65807.1 - 1.3e-20 74.0 0.0 1.5e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 TLD Glyco_hydro_18 PF00704.28 ORX65808.1 - 5.9e-20 72.2 0.7 3.7e-19 69.6 0.7 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Glucosaminidase PF01832.20 ORX65808.1 - 0.075 13.5 0.4 1.2 9.7 0.1 2.2 2 0 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase GHL10 PF02638.15 ORX65808.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 DUF3533 PF12051.8 ORX65809.1 - 3e-34 118.6 16.7 4e-34 118.2 16.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Ribosomal_60s PF00428.19 ORX65809.1 - 2 9.0 5.8 1.6 9.4 3.6 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein RNR_Alpha PF17975.1 ORX65810.1 - 9.1e-39 132.0 1.2 4.9e-38 129.7 0.0 2.7 3 0 0 3 3 3 1 Ribonucleotide reductase alpha domain Ribonuc_red_lgC PF02867.15 ORX65810.1 - 1.8e-09 36.7 0.0 0.0082 14.7 0.0 3.3 2 1 0 3 3 3 3 Ribonucleotide reductase, barrel domain Glyco_hydro_18 PF00704.28 ORX65811.1 - 3.3e-23 82.9 7.0 8.9e-23 81.5 7.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX65811.1 - 5.4e-05 23.1 24.6 5.4e-05 23.1 24.6 3.8 1 1 2 3 3 3 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX65811.1 - 0.22 11.7 6.8 0.66 10.2 6.8 1.9 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain SOG2 PF10428.9 ORX65811.1 - 5.7 6.0 11.2 7.6 5.6 11.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Glyco_hydro_18 PF00704.28 ORX65812.1 - 1.5e-23 84.0 8.9 5.2e-23 82.3 8.9 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Trypsin PF00089.26 ORX65813.1 - 1.8e-32 112.9 0.8 2.1e-32 112.7 0.8 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX65813.1 - 1.5e-06 29.2 0.2 2.7e-06 28.3 0.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Piwi PF02171.17 ORX65814.1 - 6.9e-99 330.9 0.0 9.3e-99 330.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 ORX65814.1 - 1.7e-15 57.0 0.0 4.7e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL1 PF08699.10 ORX65814.1 - 4.4e-14 51.9 0.2 8.4e-14 51.0 0.2 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 ORX65814.1 - 5e-14 53.1 0.0 9.6e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 ORX65814.1 - 1.4e-13 50.8 0.0 4.4e-13 49.2 0.0 1.8 2 0 0 2 2 2 1 PAZ domain ArgoL2 PF16488.5 ORX65814.1 - 2e-13 50.4 0.0 4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain FKBP_C PF00254.28 ORX65815.1 - 5.2e-34 116.4 0.0 7.9e-34 115.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.28 ORX65816.1 - 7.9e-33 112.7 0.0 1.2e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WD40 PF00400.32 ORX65817.1 - 1.7e-26 92.0 17.5 2.8e-06 28.0 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX65817.1 - 7.5e-08 32.6 1.3 0.13 12.6 0.0 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain adh_short PF00106.25 ORX65818.1 - 1.6e-30 106.1 0.2 1.3e-29 103.1 0.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX65818.1 - 6.4e-22 78.3 0.0 2.8e-21 76.2 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX65818.1 - 9e-05 22.5 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX65818.1 - 0.055 12.9 0.1 0.1 12.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Peptidase_M50 PF02163.22 ORX65819.1 - 9.2e-15 54.6 0.0 9.2e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M50 p450 PF00067.22 ORX65820.1 - 1e-64 219.0 0.0 1.3e-64 218.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX65821.1 - 4e-64 217.1 0.0 5.3e-64 216.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 rve_2 PF13333.6 ORX65821.1 - 0.15 12.2 0.0 0.52 10.5 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain PPR_2 PF13041.6 ORX65822.1 - 1.2e-14 54.2 1.3 2.3e-06 27.7 0.0 4.1 4 1 1 5 5 5 3 PPR repeat family PPR_3 PF13812.6 ORX65822.1 - 4e-14 52.4 0.0 1.2e-06 28.5 0.0 4.1 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR PF01535.20 ORX65822.1 - 1.3e-07 31.4 12.1 0.00033 20.7 0.0 6.5 6 2 0 6 6 6 2 PPR repeat PPR_long PF17177.4 ORX65822.1 - 4.6e-07 29.4 0.0 7e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX65822.1 - 4e-06 26.4 0.0 0.0056 16.4 0.0 2.7 2 0 0 2 2 2 2 PPR repeat Ribosomal_S13_N PF08069.12 ORX65822.1 - 0.11 12.5 0.1 21 5.3 0.0 3.4 2 1 1 3 3 3 0 Ribosomal S13/S15 N-terminal domain TPR_14 PF13428.6 ORX65822.1 - 0.53 11.2 2.9 36 5.5 0.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat MFS_1 PF07690.16 ORX65823.1 - 3.1e-23 82.3 31.9 7.4e-20 71.2 27.8 3.2 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX65823.1 - 5.9e-08 32.0 2.5 5.9e-08 32.0 2.5 3.0 1 1 2 3 3 3 2 Sugar (and other) transporter PDGLE PF13190.6 ORX65824.1 - 0.039 13.9 0.3 8.3 6.4 0.0 2.6 1 1 1 2 2 2 0 PDGLE domain MOR2-PAG1_N PF14222.6 ORX65825.1 - 3.5e-28 98.9 0.0 4.4e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Cell morphogenesis N-terminal DUF4391 PF14335.6 ORX65825.1 - 0.19 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) MOR2-PAG1_N PF14222.6 ORX65826.1 - 3.4e-38 131.9 0.7 3.7e-38 131.8 0.7 1.0 1 0 0 1 1 1 1 Cell morphogenesis N-terminal TRC8_N PF13705.6 ORX65826.1 - 0.029 13.3 0.6 0.031 13.2 0.6 1.1 1 0 0 1 1 1 0 TRC8 N-terminal domain MOR2-PAG1_mid PF14228.6 ORX65828.1 - 1.5e-08 32.8 0.1 0.00023 19.0 0.0 2.7 3 0 0 3 3 3 2 Cell morphogenesis central region KRBA1 PF15287.6 ORX65830.1 - 0.074 12.8 0.0 0.48 10.1 0.0 2.2 3 0 0 3 3 3 0 KRBA1 family repeat Glycogen_syn PF05693.13 ORX65831.1 - 0 1064.9 0.2 0 1063.0 0.2 1.7 1 1 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 ORX65831.1 - 1.7e-05 24.5 0.0 0.0014 18.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX65831.1 - 0.00028 21.3 0.0 0.019 15.4 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX65831.1 - 0.023 14.7 0.2 0.043 13.8 0.2 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Lipase_GDSL PF00657.22 ORX65832.1 - 5.6e-06 26.5 0.0 9.2e-06 25.8 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX65832.1 - 0.014 15.8 0.0 0.026 14.9 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Zip PF02535.22 ORX65834.1 - 5e-53 180.5 17.1 7e-53 180.0 17.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Dip PF17679.1 ORX65834.1 - 0.029 14.0 0.1 0.053 13.1 0.1 1.3 1 0 0 1 1 1 0 gp37/Dip protein Lipase_GDSL PF00657.22 ORX65837.1 - 0.00054 20.0 0.1 0.00079 19.5 0.1 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX65838.1 - 0.00011 22.7 0.5 0.00019 21.9 0.5 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family She9_MDM33 PF05546.11 ORX65839.1 - 4.1e-51 173.6 9.0 6e-50 169.8 8.9 2.3 1 1 0 1 1 1 1 She9 / Mdm33 family FKBP_C PF00254.28 ORX65840.1 - 8.5e-31 106.1 0.0 2.4e-30 104.7 0.0 1.8 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 ORX65840.1 - 7.3e-25 87.6 0.0 7.3e-25 87.6 0.0 2.4 2 1 0 2 2 1 1 Nucleoplasmin-like domain CCSAP PF15748.5 ORX65840.1 - 0.0039 17.4 9.3 0.0051 17.0 9.3 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Nop53 PF07767.11 ORX65840.1 - 0.0087 15.5 20.4 0.012 15.1 20.4 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) TP53IP5 PF15331.6 ORX65840.1 - 0.093 12.9 8.3 0.13 12.4 8.3 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 GAGA_bind PF06217.12 ORX65840.1 - 0.14 12.4 7.9 0.17 12.1 7.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4604 PF15377.6 ORX65840.1 - 0.23 11.9 26.8 0.33 11.4 26.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PDGF_N PF04692.13 ORX65840.1 - 0.25 12.2 8.7 0.069 13.9 4.8 1.9 1 1 1 2 2 2 0 Platelet-derived growth factor, N terminal region Presenilin PF01080.17 ORX65840.1 - 0.87 8.3 6.3 1.1 7.9 6.3 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ORX65840.1 - 1.1 9.1 14.5 1.5 8.6 14.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 ORX65840.1 - 3.9 4.5 6.4 4.4 4.3 6.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ARPC4 PF05856.12 ORX65841.1 - 2.1e-63 212.9 5.9 2.3e-63 212.8 5.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Ribosomal_L36e PF01158.18 ORX65842.1 - 2.5e-30 104.6 2.8 2.7e-30 104.5 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Transferase PF02458.15 ORX65843.1 - 1.7e-13 50.0 0.0 2.9e-10 39.4 0.0 2.6 2 1 0 2 2 2 2 Transferase family DUF1908 PF08926.11 ORX65843.1 - 0.022 13.8 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) AviRa PF11599.8 ORX65844.1 - 0.11 11.9 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa N6-adenineMlase PF10237.9 ORX65845.1 - 7.8e-46 155.8 0.0 1.1e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase mRNA_cap_C PF03919.15 ORX65845.1 - 0.055 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain Cons_hypoth95 PF03602.15 ORX65845.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.5 1 1 0 1 1 1 0 Conserved hypothetical protein 95 SpoIIE PF07228.12 ORX65846.1 - 4.6e-07 30.0 0.0 5.8e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ORX65846.1 - 0.00069 19.3 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 ORX65846.1 - 0.0042 16.7 0.1 0.0066 16.1 0.1 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C W2 PF02020.18 ORX65847.1 - 3.3e-18 65.6 3.8 3.3e-18 65.6 0.7 2.5 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon DUF727 PF05303.12 ORX65848.1 - 7.7e-09 35.6 0.0 1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Nuc_sug_transp PF04142.15 ORX65849.1 - 9.8e-111 369.9 17.3 1.2e-110 369.6 17.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 ORX65849.1 - 4.8e-07 29.3 11.4 4.8e-07 29.3 11.4 1.9 2 1 0 2 2 2 1 UAA transporter family EamA PF00892.20 ORX65849.1 - 0.0023 18.1 25.2 0.0059 16.8 3.7 2.3 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.6 ORX65849.1 - 0.0091 15.6 6.3 0.019 14.6 6.3 1.7 1 1 0 1 1 1 1 Putative multidrug resistance efflux transporter PUNUT PF16913.5 ORX65849.1 - 0.027 13.7 21.9 0.049 12.8 21.9 1.5 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport TPT PF03151.16 ORX65849.1 - 0.053 12.9 11.3 0.15 11.4 10.2 2.2 1 1 0 1 1 1 0 Triose-phosphate Transporter family CAF1 PF04857.20 ORX65850.1 - 1.6e-20 73.6 0.1 5.1e-09 35.7 0.0 2.6 2 1 0 2 2 2 2 CAF1 family ribonuclease Got1 PF04178.12 ORX65851.1 - 2.7e-32 111.5 14.3 3.7e-32 111.1 14.3 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF5345 PF17280.2 ORX65851.1 - 9.2 6.3 9.3 4.6 7.3 1.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5345) CPP1-like PF11833.8 ORX65852.1 - 0.041 13.5 0.4 0.057 13.1 0.4 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Endotoxin_N PF03945.14 ORX65852.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain Macoilin PF09726.9 ORX65852.1 - 1.7 7.1 5.3 1.9 7.0 5.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF4551 PF15087.6 ORX65852.1 - 5 5.8 7.8 5.9 5.6 7.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) adh_short PF00106.25 ORX65854.1 - 2.1e-35 122.0 0.1 2.9e-35 121.5 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX65854.1 - 1.3e-16 60.9 0.0 2e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX65854.1 - 0.00011 22.1 1.3 0.0023 17.9 1.2 2.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX65854.1 - 0.0031 17.0 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ORX65854.1 - 0.0057 15.8 0.0 0.0084 15.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Dimerisation PF08100.11 ORX65854.1 - 0.029 14.4 0.2 0.069 13.2 0.2 1.6 1 0 0 1 1 1 0 Dimerisation domain adh_short PF00106.25 ORX65855.1 - 7.3e-36 123.5 0.0 9.6e-36 123.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX65855.1 - 1.3e-20 73.9 0.0 1.8e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX65855.1 - 5.1e-07 29.8 0.5 2.2e-05 24.5 0.5 2.2 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 ORX65855.1 - 0.036 13.2 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain MutS_V PF00488.21 ORX65856.1 - 2.3e-49 168.0 0.5 6e-49 166.6 0.1 1.9 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ORX65856.1 - 2.4e-26 93.1 2.3 4.5e-26 92.3 2.3 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 ORX65856.1 - 1e-07 32.2 0.0 1.8e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 ORX65856.1 - 0.0056 17.0 0.0 0.064 13.5 0.0 2.6 3 0 0 3 3 3 1 MutS domain II AAA_14 PF13173.6 ORX65856.1 - 0.016 15.2 0.0 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 ORX65856.1 - 0.21 11.2 0.0 0.41 10.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_polI_A34 PF08208.11 ORX65857.1 - 1.2e-14 55.0 20.1 1.5e-14 54.6 20.1 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 SPATIAL PF15256.6 ORX65857.1 - 1 9.7 10.3 1.2 9.5 10.3 1.4 1 1 0 1 1 1 0 SPATIAL Pkinase_fungal PF17667.1 ORX65858.1 - 0.037 12.8 0.1 0.076 11.8 0.1 1.4 2 0 0 2 2 2 0 Fungal protein kinase Vps39_2 PF10367.9 ORX65860.1 - 9e-14 51.9 0.0 3.8e-13 49.8 0.0 2.2 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 ORX65860.1 - 0.00095 18.9 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 ORX65860.1 - 0.14 12.4 0.2 0.57 10.5 0.2 2.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 DUF3217 PF11506.8 ORX65861.1 - 0.19 11.7 0.0 0.63 10.0 0.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3217) Glyco_hydro_18 PF00704.28 ORX65862.1 - 6.1e-13 49.2 7.0 6.1e-09 36.0 3.7 2.7 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 OPT PF03169.15 ORX65863.1 - 4.4e-135 451.7 33.3 2.1e-132 442.9 33.3 2.0 1 1 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_2_1 PF04971.12 ORX65863.1 - 0.27 11.3 2.0 1.3 9.1 0.5 2.6 2 0 0 2 2 2 0 Bacteriophage P21 holin S UQ_con PF00179.26 ORX65865.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Ras PF00071.22 ORX65866.1 - 6e-52 175.5 0.0 7.2e-52 175.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX65866.1 - 1.3e-35 122.2 0.0 1.7e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX65866.1 - 3.7e-11 42.8 0.0 4.4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX65866.1 - 5.7e-06 25.9 0.0 6.7e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX65866.1 - 1.5e-05 25.0 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX65866.1 - 2.2e-05 24.5 0.0 3.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX65866.1 - 0.0043 17.4 0.1 0.01 16.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 ORX65866.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ORX65866.1 - 0.014 14.9 0.0 0.061 12.8 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 ORX65866.1 - 0.019 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Dynamin_N PF00350.23 ORX65866.1 - 0.12 12.5 0.0 0.66 10.0 0.0 1.8 1 1 1 2 2 2 0 Dynamin family AAA_24 PF13479.6 ORX65866.1 - 0.15 11.7 0.0 0.57 9.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain Pyr_redox_2 PF07992.14 ORX65867.1 - 2.8e-40 138.4 0.0 3.9e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX65867.1 - 8.1e-11 42.3 0.0 8.1e-10 39.1 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_7 PF13499.6 ORX65867.1 - 2.1e-07 31.3 0.1 0.0082 16.6 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX65867.1 - 2.2e-07 29.9 1.1 0.0002 20.7 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ORX65867.1 - 1.7e-06 27.5 0.5 0.0075 16.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ORX65867.1 - 4.5e-05 22.8 1.1 0.0011 18.4 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ORX65867.1 - 0.0019 18.0 0.6 0.0086 15.9 0.6 2.1 1 1 0 1 1 1 1 EF-hand domain pair Fas_alpha_ACP PF18325.1 ORX65868.1 - 7.8e-52 175.9 0.1 1.8e-51 174.7 0.1 1.7 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX65868.1 - 5.9e-36 124.0 0.4 1.9e-35 122.4 0.2 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain DUF1729 PF08354.10 ORX65868.1 - 1.8e-30 106.1 0.1 5.4e-25 88.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1729) FAS_meander PF17951.1 ORX65868.1 - 3.9e-25 88.4 0.0 1.3e-24 86.7 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX65868.1 - 9.1e-17 61.5 0.1 2.1e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX65868.1 - 6e-12 45.6 0.0 1.6e-09 37.8 0.0 2.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 ORX65868.1 - 6.7e-10 39.0 2.3 8.3e-07 28.8 0.6 3.0 3 0 0 3 3 3 2 Acyl transferase domain SAT PF16073.5 ORX65868.1 - 1.7e-07 31.3 0.1 5.5e-07 29.6 0.1 1.9 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 ORX65868.1 - 1.5e-05 24.6 0.0 4e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain AMP-binding PF00501.28 ORX65869.1 - 9.7e-70 235.3 3.1 6.4e-68 229.3 3.1 2.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX65869.1 - 4.8e-09 37.1 0.4 3e-08 34.5 0.0 2.6 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain SNF2_N PF00176.23 ORX65870.1 - 2.5e-50 171.2 0.1 3.9e-49 167.2 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX65870.1 - 1.4e-17 64.0 0.0 2.9e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX65870.1 - 0.00039 20.4 0.0 0.0026 17.8 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HSA PF07529.13 ORX65870.1 - 0.021 15.2 0.8 0.021 15.2 0.8 2.6 2 0 0 2 2 2 0 HSA Interfer-bind PF09294.10 ORX65870.1 - 0.087 13.2 0.2 0.19 12.1 0.2 1.5 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III SIR2 PF02146.17 ORX65871.1 - 3e-59 199.9 0.0 4.4e-59 199.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 ORX65871.1 - 0.00098 18.9 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 ORX65871.1 - 0.034 13.9 0.1 4.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain CoaE PF01121.20 ORX65873.1 - 3.1e-58 196.4 0.0 3.7e-58 196.1 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.6 ORX65873.1 - 0.0085 16.3 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX65873.1 - 0.06 13.9 0.3 0.15 12.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX65873.1 - 0.064 13.4 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain THP2 PF09432.10 ORX65873.1 - 0.072 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Tho complex subunit THP2 RabGAP-TBC PF00566.18 ORX65874.1 - 8.8e-52 175.9 0.0 1.1e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1077 PF06417.12 ORX65875.1 - 1.1e-38 131.8 2.8 1.3e-38 131.6 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) MreD PF04093.12 ORX65875.1 - 0.0011 19.1 1.2 0.024 14.7 0.2 2.0 2 0 0 2 2 2 2 rod shape-determining protein MreD DUF2781 PF10914.8 ORX65876.1 - 4.3e-37 127.8 7.9 5.2e-37 127.5 7.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) PH_9 PF15410.6 ORX65879.1 - 1.7e-06 28.4 0.0 3.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX65879.1 - 0.00048 20.6 0.1 0.013 16.0 0.2 2.7 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 ORX65879.1 - 0.046 14.2 0.0 0.08 13.4 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain REF PF05755.12 ORX65879.1 - 0.11 12.3 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) DUF1430 PF07242.11 ORX65879.1 - 0.21 11.8 0.0 0.36 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) FMO-like PF00743.19 ORX65892.1 - 3.2e-30 105.0 0.2 1.7e-10 40.0 0.1 4.5 3 1 1 4 4 4 4 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ORX65892.1 - 9.3e-10 38.2 0.0 0.0028 17.0 0.0 3.3 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX65892.1 - 1.6e-07 31.4 0.0 3.2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX65892.1 - 1.7e-05 24.2 0.1 7.7e-05 22.0 0.1 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 ORX65892.1 - 8.7e-05 22.5 0.0 0.0002 21.4 0.0 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 ORX65892.1 - 0.0012 18.5 0.1 0.0032 17.1 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX65892.1 - 0.0058 15.9 0.0 0.13 11.5 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX65892.1 - 0.021 15.4 0.0 0.2 12.2 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX65892.1 - 0.023 13.4 0.2 0.037 12.7 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Shikimate_DH PF01488.20 ORX65892.1 - 0.064 13.3 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 ORX65892.1 - 0.097 11.7 0.1 0.14 11.2 0.1 1.4 1 1 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 ORX65892.1 - 0.23 10.8 0.0 0.96 8.8 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CorA PF01544.18 ORX65893.1 - 0.0076 15.6 8.3 0.0076 15.6 8.3 4.0 4 1 0 4 4 4 1 CorA-like Mg2+ transporter protein Filament PF00038.21 ORX65893.1 - 0.011 15.4 5.8 0.011 15.4 5.8 5.6 2 1 3 5 5 5 0 Intermediate filament protein BCDHK_Adom3 PF10436.9 ORX65893.1 - 0.012 15.4 0.5 0.065 13.1 0.5 2.3 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase PCI PF01399.27 ORX65893.1 - 0.044 14.3 0.2 0.3 11.6 0.0 2.5 2 0 0 2 2 2 0 PCI domain DUF948 PF06103.11 ORX65893.1 - 0.33 11.2 13.6 8.7 6.7 0.1 5.0 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) APC_N_CC PF16689.5 ORX65893.1 - 1.2 9.2 7.8 0.62 10.2 0.4 4.0 4 0 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain DUF2462 PF09495.10 ORX65894.1 - 0.0016 19.1 14.9 0.0016 19.1 14.9 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2462) Hint_2 PF13403.6 ORX65894.1 - 0.025 14.9 0.1 0.028 14.7 0.1 1.0 1 0 0 1 1 1 0 Hint domain DUF3323 PF11796.8 ORX65895.1 - 0.056 13.3 1.4 0.066 13.1 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) DUF3539 PF12058.8 ORX65895.1 - 0.072 13.2 0.0 8 6.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3539) zf-HC3 PF16827.5 ORX65895.1 - 0.27 11.5 5.7 0.31 11.3 0.4 2.4 2 0 0 2 2 2 0 zinc-finger EamA PF00892.20 ORX65896.1 - 8.5e-16 58.4 36.5 7e-09 36.0 14.4 2.6 1 1 2 3 3 3 3 EamA-like transporter family Trypsin PF00089.26 ORX65897.1 - 2.6e-18 66.6 2.0 5.2e-18 65.7 2.0 1.5 1 0 0 1 1 1 1 Trypsin Glyco_hydro_125 PF06824.11 ORX65898.1 - 1e-158 528.6 0.0 1.2e-158 528.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) MFS_1 PF07690.16 ORX65902.1 - 3.2e-16 59.2 48.1 9.1e-15 54.4 48.0 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 ORX65903.1 - 8.9e-24 84.2 0.0 1.1e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX65903.1 - 5e-07 30.2 0.0 1.6e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX65903.1 - 0.00038 19.7 0.1 0.00055 19.2 0.1 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ORX65903.1 - 0.0017 18.3 0.0 3.8 7.5 0.0 3.9 4 0 0 4 4 4 1 FAD-NAD(P)-binding GIDA PF01134.22 ORX65903.1 - 0.083 12.0 0.4 4.7 6.2 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 ORX65903.1 - 0.11 11.2 0.4 3.6 6.2 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 ORX65903.1 - 0.13 11.3 0.1 0.37 9.8 0.1 1.6 1 1 1 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 ORX65903.1 - 0.17 10.7 0.0 0.91 8.3 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase 5_nucleotid_C PF02872.18 ORX65904.1 - 9.8e-16 58.4 0.0 2.9e-15 56.8 0.0 1.8 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ORX65904.1 - 2.5e-09 37.9 0.1 4.1e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase YmdB PF13277.6 ORX65904.1 - 0.024 14.0 0.0 0.12 11.7 0.0 1.9 1 1 0 1 1 1 0 YmdB-like protein PGA_cap PF09587.10 ORX65904.1 - 0.025 14.0 0.5 0.22 11.0 0.5 2.2 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Ribonuclease_T2 PF00445.18 ORX65905.1 - 2.7e-25 89.7 0.2 3.6e-25 89.3 0.2 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Phage_int_SAM_2 PF12834.7 ORX65905.1 - 0.15 12.8 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal RNase_H PF00075.24 ORX65906.1 - 6.4e-12 45.9 0.0 9.9e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 ORX65906.1 - 8.2e-10 38.8 0.0 2.1e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.24 ORX65907.1 - 2.4e-20 73.2 0.0 3e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 ORX65907.1 - 3.4e-11 43.3 0.1 7.7e-11 42.1 0.1 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin Phage_int_SAM_6 PF18644.1 ORX65907.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Phage integrase SAM-like domain Rad60-SLD PF11976.8 ORX65909.1 - 5.8e-16 58.1 0.4 2.8e-15 55.9 0.2 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like RRM_1 PF00076.22 ORX65910.1 - 6.8e-08 32.2 0.0 9.4e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX65910.1 - 0.0099 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RNase_Zc3h12a_2 PF14626.6 ORX65910.1 - 0.048 13.9 0.0 0.06 13.6 0.0 1.1 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain zf-Tim10_DDP PF02953.15 ORX65911.1 - 6.9e-17 60.9 3.4 8.6e-17 60.5 3.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Spore_YtfJ PF09579.10 ORX65911.1 - 0.15 12.2 2.1 0.22 11.7 2.1 1.2 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) DUF2431 PF10354.9 ORX65912.1 - 6.5e-47 159.9 0.2 1.3e-46 159.0 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Mnd1 PF03962.15 ORX65913.1 - 9e-29 99.6 0.7 1.8e-28 98.6 0.2 1.8 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 ORX65913.1 - 7.9e-19 67.5 0.8 2e-18 66.2 0.8 1.8 1 0 0 1 1 1 1 Leucine zipper with capping helix domain CCDC-167 PF15188.6 ORX65913.1 - 0.0006 20.1 4.2 0.0011 19.3 4.2 1.5 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 ABC_tran_CTD PF16326.5 ORX65913.1 - 0.00087 19.5 2.8 0.00087 19.5 2.8 1.9 1 1 1 2 2 2 1 ABC transporter C-terminal domain DUF5082 PF16888.5 ORX65913.1 - 0.033 14.5 2.8 0.059 13.7 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Penicillinase_R PF03965.16 ORX65913.1 - 0.038 14.4 0.0 0.064 13.6 0.0 1.5 1 1 0 1 1 1 0 Penicillinase repressor FlxA PF14282.6 ORX65913.1 - 0.15 12.0 4.1 0.24 11.4 4.1 1.3 1 0 0 1 1 1 0 FlxA-like protein ISG65-75 PF11727.8 ORX65913.1 - 0.27 10.4 2.4 0.37 10.0 2.4 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DivIC PF04977.15 ORX65913.1 - 0.3 10.9 4.0 0.42 10.4 0.6 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF1192 PF06698.11 ORX65913.1 - 1.8 8.7 5.3 0.28 11.3 0.4 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) PKcGMP_CC PF16808.5 ORX65913.1 - 5.3 7.0 7.1 1.5 8.7 0.2 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Proteasome PF00227.26 ORX65914.1 - 2.1e-52 177.4 0.4 2.5e-52 177.1 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Mito_carr PF00153.27 ORX65915.1 - 5.2e-65 215.4 3.5 3.4e-22 78.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein FSH1 PF03959.13 ORX65916.1 - 1.1e-50 172.3 0.0 1.2e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) FSH1 PF03959.13 ORX65917.1 - 2.1e-54 184.4 0.0 2.5e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 ORX65917.1 - 0.0026 17.6 0.0 0.0073 16.1 0.0 1.7 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Thioesterase PF00975.20 ORX65917.1 - 0.04 14.0 0.0 0.063 13.4 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain zf-Tim10_DDP PF02953.15 ORX65918.1 - 2.2e-21 75.3 3.6 2.6e-21 75.0 3.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger HLH PF00010.26 ORX65919.1 - 5.6e-14 51.8 0.2 1.2e-13 50.7 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain zf-C4H2 PF10146.9 ORX65919.1 - 0.055 13.8 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein UQ_con PF00179.26 ORX65920.1 - 2.4e-41 140.7 0.0 2.7e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX65920.1 - 0.084 13.2 0.2 0.14 12.5 0.2 1.5 1 1 0 1 1 1 0 RWD domain SNF2_N PF00176.23 ORX65921.1 - 6.2e-52 176.5 0.1 3e-51 174.2 0.1 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX65921.1 - 5.4e-16 58.9 0.0 2.2e-15 56.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX65921.1 - 4.6e-06 26.8 0.0 9.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 ORX65921.1 - 2.4e-05 24.1 4.4 2.4e-05 24.1 4.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX65921.1 - 3e-05 23.8 2.5 3e-05 23.8 2.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX65921.1 - 3.8e-05 23.6 1.0 3.8e-05 23.6 1.0 3.2 3 1 1 4 4 4 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX65921.1 - 0.00052 19.8 3.3 0.0015 18.4 3.3 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ORX65921.1 - 0.0021 18.0 4.4 0.0021 18.0 4.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ORX65921.1 - 0.0038 17.5 3.8 0.0038 17.5 3.8 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX65921.1 - 0.0085 15.9 6.2 0.0085 15.9 6.2 3.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF1117 PF06547.12 ORX65921.1 - 0.03 14.9 2.4 5.9 7.5 1.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) zinc_ribbon_4 PF13717.6 ORX65921.1 - 1.8 8.6 5.3 2.4 8.1 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain PhzC-PhzF PF02567.16 ORX65923.1 - 3.9e-61 207.0 0.0 9.1e-61 205.8 0.0 1.5 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein PhzC-PhzF PF02567.16 ORX65924.1 - 1.2e-59 202.1 0.0 1.4e-59 201.9 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein DAP_epimerase PF01678.19 ORX65924.1 - 0.18 12.0 0.0 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Diaminopimelate epimerase PhzC-PhzF PF02567.16 ORX65925.1 - 7.1e-35 120.8 0.0 1.3e-34 120.0 0.0 1.4 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein PhzC-PhzF PF02567.16 ORX65926.1 - 1e-52 179.4 0.1 1.3e-30 106.9 0.3 2.0 2 0 0 2 2 2 2 Phenazine biosynthesis-like protein Helicase_Sgs1 PF11408.8 ORX65926.1 - 0.2 11.7 0.0 0.39 10.8 0.0 1.4 1 0 0 1 1 1 0 Sgs1 RecQ helicase Rhodanese PF00581.20 ORX65927.1 - 7.7e-07 29.6 0.1 1e-06 29.2 0.1 1.4 1 1 0 1 1 1 1 Rhodanese-like domain PhzC-PhzF PF02567.16 ORX65928.1 - 1.3e-25 90.4 0.1 5.9e-13 48.9 0.0 2.0 2 0 0 2 2 2 2 Phenazine biosynthesis-like protein DAP_epimerase PF01678.19 ORX65928.1 - 0.16 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Diaminopimelate epimerase DUF155 PF02582.14 ORX65929.1 - 2.3e-50 171.1 0.4 3.3e-50 170.6 0.4 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 PhzC-PhzF PF02567.16 ORX65930.1 - 1e-59 202.4 0.0 1.2e-59 202.1 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein DAP_epimerase PF01678.19 ORX65930.1 - 0.062 13.5 0.0 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 Diaminopimelate epimerase Acetyltransf_9 PF13527.7 ORX65931.1 - 3.1e-05 24.0 0.0 0.00022 21.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX65931.1 - 9.2e-05 22.8 0.0 0.00023 21.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX65931.1 - 0.00046 20.4 0.1 0.0014 18.9 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ORX65931.1 - 0.0073 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ORX65931.1 - 0.0082 16.1 0.0 0.02 14.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Pro_Al_protease PF02983.14 ORX65931.1 - 0.086 12.9 0.2 0.19 11.8 0.2 1.6 1 0 0 1 1 1 0 Alpha-lytic protease prodomain DDE_Tnp_4 PF13359.6 ORX65934.1 - 3.7e-05 23.5 0.0 4.3e-05 23.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease AMP-binding PF00501.28 ORX65939.1 - 3.8e-95 319.0 0.0 5.4e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Erv26 PF04148.13 ORX65939.1 - 2.5e-27 96.1 7.8 1.3e-26 93.7 7.8 2.1 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 SIS PF01380.22 ORX65941.1 - 1.5e-62 209.2 0.1 1.1e-35 122.3 0.0 2.5 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ORX65941.1 - 2.7e-16 60.0 0.0 7.1e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ORX65941.1 - 3.1e-13 49.7 0.0 6.7e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ORX65941.1 - 6.6e-05 21.9 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 ORX65941.1 - 0.064 13.3 0.0 0.2 11.7 0.0 1.9 1 1 1 2 2 2 0 SIS domain Gpr1_Fun34_YaaH PF01184.19 ORX65943.1 - 1.8e-30 106.1 7.9 2.2e-30 105.9 7.9 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4225 PF13988.6 ORX65943.1 - 0.26 10.8 0.4 0.49 9.9 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4225) Gaa1 PF04114.14 ORX65944.1 - 3.1e-65 221.1 15.5 2.4e-47 162.1 11.6 3.8 2 1 1 3 3 3 2 Gaa1-like, GPI transamidase component Peptidase_S9 PF00326.21 ORX65945.1 - 7.6e-31 107.2 0.4 1.4e-30 106.4 0.4 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 ORX65945.1 - 0.00045 20.1 0.0 0.07 13.1 0.0 3.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat AXE1 PF05448.12 ORX65945.1 - 0.0061 15.3 0.0 1.7 7.2 0.0 2.3 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Glyco_hydro_47 PF01532.20 ORX65946.1 - 1.6e-136 455.8 3.0 1.9e-94 317.1 0.3 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 PIF6 PF05341.11 ORX65946.1 - 0.18 12.0 0.0 0.48 10.6 0.0 1.7 1 0 0 1 1 1 0 Per os infectivity factor 6 Peptidase_S8 PF00082.22 ORX65947.1 - 2.4e-71 240.4 0.2 3.6e-71 239.9 0.2 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 ORX65947.1 - 4.1e-25 88.4 0.0 6.4e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Tripeptidyl peptidase II DEAD PF00270.29 ORX65949.1 - 8.2e-48 162.5 0.0 1.1e-46 158.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX65949.1 - 7.5e-30 103.5 0.1 2.4e-29 101.9 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX65949.1 - 0.00072 19.6 0.0 0.0055 16.7 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2608 PF11019.8 ORX65949.1 - 0.028 13.9 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Pkinase PF00069.25 ORX65950.1 - 1.3e-62 211.6 0.0 1.9e-62 211.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF3543 PF12063.8 ORX65950.1 - 1.2e-43 149.3 0.5 1.2e-43 149.3 0.5 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.17 ORX65950.1 - 2.9e-41 141.5 0.0 4.6e-41 140.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX65950.1 - 0.0054 16.1 0.0 0.026 13.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX65950.1 - 0.034 12.9 0.0 0.097 11.4 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase MIT PF04212.18 ORX65950.1 - 0.56 10.3 5.4 4.1 7.5 0.2 3.8 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Proteasome PF00227.26 ORX65951.1 - 1.1e-34 119.6 0.0 1.3e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Cytochrom_C1 PF02167.15 ORX65951.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Cytochrome C1 family Ribosomal_S5 PF00333.20 ORX65952.1 - 1.7e-28 98.4 0.6 1.7e-28 98.4 0.6 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ORX65952.1 - 4.4e-25 86.9 0.1 7.1e-25 86.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 ORX65952.1 - 1.9 9.1 14.3 4.2 8.0 14.3 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Trypsin PF00089.26 ORX65953.1 - 1.1e-36 126.7 0.1 2.3e-36 125.7 0.1 1.5 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.6 ORX65953.1 - 0.012 16.5 0.1 0.024 15.5 0.1 1.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain Prenyltrans PF00432.21 ORX65955.1 - 1.8e-42 142.8 13.0 3e-09 36.4 0.1 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ORX65955.1 - 0.0017 17.5 0.0 0.032 13.3 0.0 2.6 3 1 0 3 3 3 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ORX65955.1 - 0.0062 15.7 0.0 1.6 7.8 0.0 3.0 1 1 2 3 3 3 2 Squalene-hopene cyclase N-terminal domain His_Phos_2 PF00328.22 ORX65957.1 - 1.4e-17 64.1 0.3 9.3e-17 61.4 0.3 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) ATG27 PF09451.10 ORX65958.1 - 1.1e-51 176.2 0.0 1.4e-51 175.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ORX65958.1 - 7.3e-08 32.6 0.1 0.0059 16.7 0.0 2.5 1 1 2 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 ORX65958.1 - 8.8e-07 28.3 0.9 1.3e-06 27.7 0.3 1.5 2 0 0 2 2 2 1 Mannose-6-phosphate receptor Dopey_N PF04118.14 ORX65959.1 - 6.8e-103 344.0 0.5 1.1e-102 343.3 0.5 1.3 1 0 0 1 1 1 1 Dopey, N-terminal CxC3 PF18804.1 ORX65959.1 - 0.089 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases CCDC53 PF10152.9 ORX65959.1 - 1.1 9.7 4.8 0.52 10.7 1.8 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex NatB_MDM20 PF09797.9 ORX65961.1 - 1.4e-36 126.3 2.5 3.9e-20 72.1 0.0 3.2 3 0 0 3 3 3 2 N-acetyltransferase B complex (NatB) non catalytic subunit HalOD1 PF18545.1 ORX65961.1 - 0.04 14.2 0.1 0.04 14.2 0.1 2.4 4 0 0 4 4 4 0 Halobacterial output domain 1 Fis1_TPR_C PF14853.6 ORX65961.1 - 0.073 13.2 0.1 0.26 11.4 0.1 2.0 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ORX65961.1 - 1.5 9.3 0.0 1.5 9.3 0.0 3.3 4 0 0 4 4 4 0 Alkyl sulfatase dimerisation TPR_19 PF14559.6 ORX65961.1 - 2.1 8.9 8.9 0.72 10.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat LSM PF01423.22 ORX65962.1 - 2.6e-18 65.5 0.2 2.9e-18 65.3 0.2 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX65962.1 - 0.00016 21.8 0.0 0.00017 21.6 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ORX65962.1 - 0.03 14.4 0.0 0.032 14.3 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain UBA_4 PF14555.6 ORX65963.1 - 1.5e-16 59.9 0.0 3e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 ORX65963.1 - 2.1e-14 53.5 0.0 4.9e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like RAP80_UIM PF18282.1 ORX65963.1 - 0.01 15.6 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 RAP80 N-terminal ubiquitin interaction motif Thioredoxin_2 PF13098.6 ORX65963.1 - 0.051 14.0 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain UIM PF02809.20 ORX65963.1 - 0.094 12.7 1.8 0.21 11.6 1.8 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif UBX PF00789.20 ORX65963.1 - 0.11 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 UBX domain Thioredox_DsbH PF03190.15 ORX65963.1 - 0.21 11.5 0.0 0.39 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Pkinase PF00069.25 ORX65964.1 - 1e-44 152.9 0.0 1e-21 77.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX65964.1 - 1.3e-33 116.4 0.0 5.7e-16 58.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase NOB1_Zn_bind PF08772.11 ORX65965.1 - 5.1e-32 109.8 1.3 1e-31 108.9 1.3 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 ORX65965.1 - 8.1e-24 83.9 0.0 2.1e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 PIN domain of ribonuclease zf-NADH-PPase PF09297.11 ORX65965.1 - 0.0051 16.4 3.4 0.027 14.1 0.5 2.4 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 ORX65965.1 - 0.08 13.0 0.9 0.14 12.2 0.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ORX65965.1 - 0.088 12.6 0.3 0.19 11.5 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain DUF3701 PF12482.8 ORX65966.1 - 0.082 13.0 0.1 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 Phage integrase protein Rax2 PF12768.7 ORX65967.1 - 0.00093 18.7 0.0 0.0019 17.7 0.0 1.5 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Trypsin PF00089.26 ORX65967.1 - 0.013 15.4 0.1 0.028 14.2 0.1 1.7 1 1 0 1 1 1 0 Trypsin Mid2 PF04478.12 ORX65967.1 - 0.019 14.8 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor CD34_antigen PF06365.12 ORX65967.1 - 0.23 11.0 2.3 1.1 8.7 2.4 1.8 1 1 0 1 1 1 0 CD34/Podocalyxin family Pex14_N PF04695.13 ORX65967.1 - 3.8 8.1 11.5 3.1 8.4 7.1 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_46 PF01374.18 ORX65968.1 - 2.4e-44 151.5 1.1 6.1e-44 150.2 1.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 Glyco_hydro_46 PF01374.18 ORX65969.1 - 9.1e-44 149.6 3.2 3.4e-43 147.7 3.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 zf-PHD-like PF15446.6 ORX65970.1 - 0.23 11.1 2.4 2 8.0 0.0 2.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Med20 PF08612.11 ORX65971.1 - 3.8e-21 75.5 0.0 5.9e-21 74.9 0.0 1.3 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex AA_permease PF00324.21 ORX65972.1 - 1.6e-84 284.2 43.4 2e-58 198.2 28.2 3.2 2 2 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 ORX65972.1 - 7.2e-23 81.1 40.7 3e-16 59.3 27.3 3.1 1 1 1 2 2 2 2 Amino acid permease MMR_HSR1 PF01926.23 ORX65973.1 - 4.4e-15 55.8 0.0 6.8e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 ORX65973.1 - 1.9e-06 27.2 0.0 2.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 ORX65973.1 - 3e-06 27.2 0.0 4.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 ORX65973.1 - 5.6e-06 26.0 0.0 8.9e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX65973.1 - 0.00013 22.0 0.4 0.046 13.8 0.1 2.3 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 ORX65973.1 - 0.00017 21.0 0.0 0.00032 20.1 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_18 PF13238.6 ORX65973.1 - 0.0095 16.5 0.1 0.023 15.2 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX65973.1 - 0.031 14.7 0.1 0.073 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 ORX65973.1 - 0.049 12.9 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Septin Roc PF08477.13 ORX65973.1 - 0.092 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase CRAL_TRIO PF00650.20 ORX65974.1 - 1.9e-17 63.4 0.0 5.6e-15 55.4 0.0 2.2 1 1 1 2 2 2 2 CRAL/TRIO domain Ank_2 PF12796.7 ORX65975.1 - 2.4e-11 44.1 0.1 1.1e-08 35.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX65975.1 - 9.7e-11 42.0 2.3 7.6e-05 23.2 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX65975.1 - 3.7e-08 33.0 0.0 0.44 11.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ORX65975.1 - 1.1e-07 32.0 0.1 0.05 14.0 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX65975.1 - 7.1e-05 23.1 0.3 0.38 11.3 0.0 4.2 3 1 1 4 4 4 1 Ankyrin repeat RNA_pol_Rpb2_1 PF04563.15 ORX65975.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase beta subunit DUF249 PF03158.13 ORX65975.1 - 0.14 11.9 0.1 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 Multigene family 530 protein WSK PF03832.13 ORX65975.1 - 7.1 6.4 6.3 0.52 10.0 1.0 1.9 2 0 0 2 2 2 0 WSK motif Fumble PF03630.14 ORX65976.1 - 7.6e-59 199.5 0.0 7e-47 160.2 0.0 2.0 1 1 1 2 2 2 2 Fumble BcrAD_BadFG PF01869.20 ORX65976.1 - 0.0031 17.1 0.4 0.16 11.4 0.1 2.5 2 1 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family AlaDh_PNT_N PF05222.15 ORX65977.1 - 2.8e-26 92.4 0.0 4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 ORX65977.1 - 4.1e-05 23.0 0.2 0.0003 20.1 0.0 2.2 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Rpp20 PF12328.8 ORX65978.1 - 1.2e-08 35.0 0.1 1.5e-08 34.7 0.1 1.1 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 ORX65978.1 - 1.2e-06 28.2 0.1 1.7e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Alba Glycos_transf_3 PF00591.21 ORX65979.1 - 2.9e-71 240.0 0.0 4e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_transf_3 PF00591.21 ORX65980.1 - 4.4e-78 262.4 0.0 6.6e-78 261.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ORX65980.1 - 1e-10 41.3 0.4 2.1e-10 40.3 0.4 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain HTH_IclR PF09339.10 ORX65980.1 - 0.14 12.0 0.4 0.55 10.1 0.2 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain Lamprin PF06403.11 ORX65981.1 - 0.002 18.1 29.6 0.0038 17.2 29.6 1.6 1 1 0 1 1 1 1 Lamprin Keratin_2_head PF16208.5 ORX65981.1 - 0.2 11.8 20.0 0.21 11.7 20.0 1.1 1 0 0 1 1 1 0 Keratin type II head Syja_N PF02383.18 ORX65982.1 - 1.7e-60 205.0 0.0 2.9e-60 204.2 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 ORX65982.1 - 6.6e-09 35.6 0.4 1.3e-08 34.6 0.4 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family F-box-like PF12937.7 ORX65983.1 - 5.5e-07 29.4 0.3 1.8e-06 27.8 0.3 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ORX65983.1 - 0.00029 21.1 3.7 0.54 10.8 0.1 4.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX65983.1 - 0.00078 19.3 0.6 0.024 14.5 0.3 2.8 2 0 0 2 2 2 1 F-box domain UvrD-helicase PF00580.21 ORX66004.1 - 1.2e-24 87.4 0.0 1.7e-24 87.0 0.0 1.1 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ORX66004.1 - 2.2e-13 50.8 0.0 3.5e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX66004.1 - 0.00012 21.9 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 ORX66004.1 - 0.072 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain S10_plectin PF03501.15 ORX66005.1 - 1.2e-44 150.3 0.0 1.5e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Plectin/S10 domain TrmB PF01978.19 ORX66005.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF4364 PF14277.6 ORX66005.1 - 0.071 12.9 0.0 0.097 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Kinase-like PF14531.6 ORX66005.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Mito_carr PF00153.27 ORX66006.1 - 1.5e-57 191.6 1.1 3e-19 68.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PT-VENN PF04829.13 ORX66006.1 - 0.22 11.6 0.2 0.22 11.6 0.2 2.3 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif Mito_carr PF00153.27 ORX66007.1 - 1.4e-33 114.7 7.3 7.5e-15 54.6 0.4 5.4 3 3 1 4 4 4 4 Mitochondrial carrier protein DUF2315 PF10231.9 ORX66008.1 - 4.4e-27 94.6 0.2 9.5e-27 93.5 0.2 1.6 1 0 0 1 1 1 1 Apoptogenic protein 1 TPR_12 PF13424.6 ORX66008.1 - 0.38 11.1 4.1 1.3 9.4 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1751 PF08551.10 ORX66009.1 - 2e-21 76.4 3.7 4.3e-21 75.3 3.7 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 ORX66009.1 - 0.01 15.8 6.4 0.022 14.7 6.4 1.5 1 1 0 1 1 1 0 Rhomboid family SAICAR_synt PF01259.18 ORX66010.1 - 1.4e-73 247.7 0.0 1.7e-73 247.4 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase WD40 PF00400.32 ORX66011.1 - 5e-34 115.8 20.0 1.4e-10 41.5 1.0 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66011.1 - 1.7e-21 76.3 0.7 1.9e-06 28.1 0.1 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ORX66011.1 - 4.2e-05 23.4 0.5 8.4e-05 22.4 0.5 1.6 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 ORX66011.1 - 0.0013 18.7 0.2 1.4 8.7 0.0 3.6 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX66011.1 - 0.022 13.4 0.0 4.2 5.9 0.0 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX66011.1 - 0.11 11.4 0.2 9.3 5.1 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 ORX66011.1 - 0.17 11.9 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region FRG2 PF15315.6 ORX66011.1 - 0.65 10.2 3.2 0.97 9.6 3.2 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 FMN_red PF03358.15 ORX66012.1 - 9.9e-09 35.1 0.0 2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX66012.1 - 5.8e-08 32.7 0.0 7.5e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX66012.1 - 0.0097 16.1 0.1 0.042 14.1 0.1 2.1 2 1 0 2 2 2 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX66012.1 - 0.12 12.6 0.0 17 5.6 0.1 2.2 1 1 1 2 2 2 0 Flavodoxin domain DUF997 PF06196.12 ORX66014.1 - 0.07 13.1 5.4 0.18 11.8 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF997) ANAPC4 PF12896.7 ORX66017.1 - 6e-13 48.8 0.0 8.7e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 ORX66017.1 - 2.1e-12 47.2 0.0 4.6e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Sen15 PF09631.10 ORX66018.1 - 5.7e-17 61.8 0.1 6.9e-17 61.6 0.1 1.1 1 0 0 1 1 1 1 Sen15 protein Nup153 PF08604.10 ORX66018.1 - 0.066 12.0 0.0 0.075 11.8 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup153-like USP7_ICP0_bdg PF12436.8 ORX66019.1 - 9.4e-24 84.0 0.0 1.6e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 ORX66019.1 - 4.6e-12 46.0 0.0 6.5e-11 42.2 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66019.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase NUC153 PF08159.12 ORX66020.1 - 6.4e-08 32.3 4.2 6.4e-08 32.3 4.2 1.9 2 0 0 2 2 2 1 NUC153 domain ANAPC4_WD40 PF12894.7 ORX66020.1 - 0.00099 19.4 0.0 0.077 13.3 0.0 3.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain HECT PF00632.25 ORX66021.1 - 7.9e-67 225.9 0.0 5.9e-54 183.6 0.0 2.2 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) zf-RING_2 PF13639.6 ORX66022.1 - 2.6e-06 27.7 16.4 5.6e-06 26.6 16.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX66022.1 - 4.3e-06 26.5 15.7 4.3e-06 26.5 15.7 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX66022.1 - 1.6e-05 24.6 15.9 1.6e-05 24.6 15.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX66022.1 - 0.00018 21.3 12.0 0.00018 21.3 12.0 2.1 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) PWI PF01480.17 ORX66022.1 - 0.0017 18.6 0.0 0.0033 17.7 0.0 1.4 1 0 0 1 1 1 1 PWI domain zf-rbx1 PF12678.7 ORX66022.1 - 0.0025 18.1 15.9 0.011 16.0 15.9 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX66022.1 - 0.09 12.8 13.4 0.069 13.2 11.5 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 ORX66022.1 - 0.32 11.0 16.8 0.17 11.9 13.8 1.9 1 1 1 2 2 2 0 zinc-RING finger domain DUF2616 PF11077.8 ORX66022.1 - 6.2 6.5 9.9 8.2 6.1 9.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2616) DUF2700 PF10912.8 ORX66023.1 - 0.69 9.9 13.3 0.72 9.9 10.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2700) Motile_Sperm PF00635.26 ORX66024.1 - 7.6e-26 90.1 0.0 8.2e-26 90.0 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF5001 PF16392.5 ORX66024.1 - 0.018 14.9 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Ig-like domain ASH PF15780.5 ORX66024.1 - 0.04 14.1 0.0 0.051 13.8 0.0 1.1 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CDC48_2 PF02933.17 ORX66024.1 - 0.056 13.2 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 DUF756 PF05506.12 ORX66024.1 - 0.084 13.8 0.0 0.1 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF756) Ras PF00071.22 ORX66025.1 - 2e-47 160.8 0.0 2.3e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66025.1 - 9.4e-21 74.3 0.0 2.5e-20 72.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66025.1 - 2.1e-06 27.3 0.0 2.9e-06 26.8 0.0 1.2 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX66025.1 - 0.0026 17.7 0.0 0.38 10.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ORX66025.1 - 0.0042 16.5 0.0 0.0049 16.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ORX66025.1 - 0.074 12.8 0.0 2.4 7.9 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ORX66025.1 - 0.097 13.0 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 ORX66025.1 - 0.18 10.9 0.0 7.3 5.6 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit Ras PF00071.22 ORX66026.1 - 7.4e-35 119.9 0.0 8.3e-35 119.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66026.1 - 6.1e-11 42.6 0.0 9.4e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66026.1 - 0.084 12.3 0.0 0.098 12.1 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Ras PF00071.22 ORX66027.1 - 3e-29 101.7 0.0 3.9e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66027.1 - 6.2e-14 52.3 0.0 8.1e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66027.1 - 7.3e-07 28.8 0.0 1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ORX66027.1 - 0.024 13.8 0.0 3 6.9 0.0 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Gtr1_RagA PF04670.12 ORX66027.1 - 0.026 13.9 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Zip PF02535.22 ORX66028.1 - 2.3e-26 92.8 2.3 4e-12 46.0 0.0 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter ATG22 PF11700.8 ORX66029.1 - 4.1e-81 273.0 21.6 4.4e-80 269.6 21.6 2.1 1 1 0 1 1 1 1 Vacuole effluxer Atg22 like ATG22 PF11700.8 ORX66030.1 - 2e-15 56.4 5.5 2.9e-06 26.2 6.2 3.5 3 1 0 3 3 3 3 Vacuole effluxer Atg22 like Enolase_like_N PF18374.1 ORX66030.1 - 0.017 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Enolase N-terminal domain-like CAP PF00188.26 ORX66031.1 - 1.2e-11 45.5 0.1 1.9e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ufd2P_core PF10408.9 ORX66033.1 - 1.3e-126 423.7 0.0 6.2e-126 421.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 ORX66033.1 - 6.6e-18 64.6 0.3 2.7e-17 62.7 0.3 2.1 1 0 0 1 1 1 1 U-box domain DUF2408 PF10303.9 ORX66033.1 - 0.11 13.1 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Ras PF00071.22 ORX66034.1 - 4.9e-55 185.6 0.0 5.7e-55 185.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66034.1 - 3.4e-21 75.7 0.0 5.3e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66034.1 - 3.3e-06 26.7 0.0 4.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX66034.1 - 0.019 14.5 0.0 0.056 13.0 0.0 1.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX66034.1 - 0.022 14.2 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX66034.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF1748 PF08520.10 ORX66036.1 - 6.4e-08 32.4 0.0 4e-07 29.8 0.0 2.1 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF1748) VPR PF00522.18 ORX66036.1 - 0.12 12.5 0.7 0.31 11.1 0.4 1.8 1 1 0 1 1 1 0 VPR/VPX protein MIP PF00230.20 ORX66038.1 - 5.7e-38 130.9 4.8 6.5e-38 130.7 4.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF1748 PF08520.10 ORX66039.1 - 0.016 15.1 0.1 0.044 13.7 0.1 1.7 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF1748) AAA PF00004.29 ORX66040.1 - 5.9e-40 136.7 0.0 7.1e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX66040.1 - 1.4e-06 28.8 1.7 3e-05 24.5 1.7 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ORX66040.1 - 1.7e-05 24.5 0.0 2.4e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ORX66040.1 - 3.3e-05 24.1 0.0 0.00074 19.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX66040.1 - 7.4e-05 23.0 0.1 0.015 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX66040.1 - 0.00024 21.1 0.1 0.005 16.8 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX66040.1 - 0.002 18.3 0.1 0.0032 17.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX66040.1 - 0.0028 17.9 0.0 0.0042 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX66040.1 - 0.0028 17.4 0.0 0.0068 16.2 0.0 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 ORX66040.1 - 0.0085 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ORX66040.1 - 0.0093 15.4 0.2 0.016 14.6 0.2 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ORX66040.1 - 0.022 14.7 0.2 0.063 13.2 0.2 1.9 1 1 0 1 1 1 0 NACHT domain RuvB_N PF05496.12 ORX66040.1 - 0.022 14.5 0.2 0.094 12.5 0.1 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ORX66040.1 - 0.051 14.1 0.0 0.061 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX66040.1 - 0.085 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 ORX66040.1 - 0.093 12.1 0.0 0.19 11.0 0.0 1.5 2 0 0 2 2 2 0 KaiC Sigma54_activat PF00158.26 ORX66040.1 - 0.1 12.3 0.0 0.48 10.1 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 ORX66040.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 ORX66040.1 - 0.11 12.0 0.1 0.24 10.9 0.1 1.5 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 ORX66040.1 - 0.12 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX66040.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Sulphotransf PF09037.10 ORX66040.1 - 0.22 11.0 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Stf0 sulphotransferase AAA_24 PF13479.6 ORX66040.1 - 0.27 10.9 0.0 0.35 10.6 0.0 1.3 1 1 0 1 1 1 0 AAA domain ABC2_membrane PF01061.24 ORX66041.1 - 6e-42 143.4 19.9 6e-42 143.4 19.9 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ORX66041.1 - 1.6e-23 83.7 0.0 2.5e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ORX66041.1 - 1.6e-05 24.9 0.3 2.8e-05 24.1 0.3 1.3 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ORX66041.1 - 4.8e-05 22.9 0.0 0.24 10.8 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX66041.1 - 0.00015 21.4 0.8 0.0071 16.1 0.4 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX66041.1 - 0.00088 19.7 0.0 0.0019 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ORX66041.1 - 0.0014 18.2 0.2 0.0027 17.3 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ORX66041.1 - 0.0017 18.2 0.8 0.039 13.7 0.8 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX66041.1 - 0.0023 18.2 0.2 0.0064 16.8 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ORX66041.1 - 0.0041 17.7 1.1 0.0063 17.0 1.1 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ORX66041.1 - 0.015 15.2 0.8 0.032 14.1 0.2 1.8 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 ORX66041.1 - 0.021 15.0 0.1 0.049 13.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX66041.1 - 0.037 14.3 0.2 0.065 13.5 0.2 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX66041.1 - 0.052 13.9 0.0 0.098 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ABC2_membrane_3 PF12698.7 ORX66041.1 - 0.099 11.7 25.2 0.15 11.1 25.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_30 PF13604.6 ORX66041.1 - 0.1 12.3 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ORX66041.1 - 0.15 12.1 0.2 0.71 9.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SRPRB PF09439.10 ORX66041.1 - 0.15 11.5 0.3 0.25 10.8 0.3 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX66041.1 - 0.19 11.8 0.2 0.4 10.8 0.2 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 ORX66041.1 - 0.2 12.2 0.0 0.41 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX66041.1 - 0.27 10.8 0.6 0.41 10.2 0.6 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 ORX66041.1 - 0.3 11.0 1.5 3.2 7.6 0.6 2.2 2 0 0 2 2 2 0 NTPase ABC2_membrane PF01061.24 ORX66042.1 - 6.5e-08 32.3 7.1 6.5e-08 32.3 7.1 1.6 2 0 0 2 2 2 1 ABC-2 type transporter FLILHELTA PF10306.9 ORX66043.1 - 9e-16 58.1 0.0 1.7e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 ORX66043.1 - 0.024 15.2 0.2 0.036 14.6 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) EB1 PF03271.17 ORX66044.1 - 7.5e-13 48.5 0.3 1.5e-12 47.6 0.3 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 ORX66044.1 - 5.6e-09 36.2 0.2 1.2e-08 35.1 0.1 1.5 2 0 0 2 2 2 1 Calponin homology (CH) domain MscS_porin PF12795.7 ORX66044.1 - 0.013 15.0 0.1 0.023 14.2 0.1 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DPM3 PF08285.11 ORX66045.1 - 1.2e-28 99.2 0.1 1.3e-28 99.0 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Glyco_transf_41 PF13844.6 ORX66046.1 - 1.2e-110 370.1 2.4 8.6e-52 176.1 0.0 4.2 3 1 1 4 4 4 3 Glycosyl transferase family 41 TPR_1 PF00515.28 ORX66046.1 - 3.8e-17 61.3 1.8 0.024 14.4 0.0 6.6 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX66046.1 - 5.9e-17 60.4 0.4 4.2e-05 23.4 0.1 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX66046.1 - 3.3e-15 54.9 1.0 0.032 14.3 0.0 6.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX66046.1 - 1.9e-13 49.7 0.5 0.023 15.1 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX66046.1 - 5.8e-12 45.1 3.1 0.0094 15.6 0.0 6.4 4 2 3 7 7 7 3 TPR repeat TPR_10 PF13374.6 ORX66046.1 - 2.4e-11 43.1 12.3 0.0026 17.6 0.1 6.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX66046.1 - 5e-11 42.7 2.6 1.1 9.6 0.0 6.1 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ORX66046.1 - 6.9e-10 38.3 3.0 0.082 13.0 0.1 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX66046.1 - 2e-05 25.0 2.7 0.26 12.2 0.0 5.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX66046.1 - 0.00055 20.5 0.4 0.91 10.2 0.0 4.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX66046.1 - 0.0045 17.1 0.5 4.2 7.6 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX66046.1 - 0.025 15.1 0.6 44 4.7 0.1 4.3 3 1 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 ORX66047.1 - 1.2e-61 208.5 0.0 2e-61 207.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66047.1 - 8.8e-30 103.8 0.0 1.3e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX66047.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Baculo_LEF5 PF04838.12 ORX66050.1 - 0.022 14.8 0.3 0.022 14.8 0.3 1.4 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 Ald_Xan_dh_C2 PF02738.18 ORX66053.1 - 8.5e-152 506.4 0.6 1.2e-147 492.7 0.6 3.3 1 1 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ORX66053.1 - 3.7e-47 160.2 0.0 7.3e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 ORX66053.1 - 7.4e-13 48.8 0.2 1.2e-11 44.9 0.2 2.7 1 1 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.27 ORX66053.1 - 8e-10 38.5 0.6 2.7e-09 36.9 0.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain CO_deh_flav_C PF03450.17 ORX66053.1 - 5.4e-09 36.1 1.4 6.7e-08 32.6 1.4 2.8 1 1 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 ORX66053.1 - 0.00049 20.1 0.1 0.0016 18.4 0.1 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain DUF2663 PF10864.8 ORX66056.1 - 0.14 12.5 0.1 0.2 12.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2663) RRM_1 PF00076.22 ORX66058.1 - 1.2e-32 111.5 0.0 2.5e-17 62.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4140 PF13600.6 ORX66058.1 - 0.021 15.2 0.1 0.021 15.2 0.1 4.2 2 1 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) RRM_7 PF16367.5 ORX66058.1 - 0.064 13.4 0.0 2.5 8.3 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ORX66058.1 - 0.082 12.9 0.0 8 6.6 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Metallophos PF00149.28 ORX66059.1 - 1.1e-09 39.2 0.1 2.2e-09 38.1 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AMP-binding PF00501.28 ORX66060.1 - 2e-88 296.9 0.1 9.4e-88 294.6 0.1 1.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX66060.1 - 5.7e-14 52.9 0.2 1.8e-13 51.3 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain WD40 PF00400.32 ORX66061.1 - 3 8.8 11.4 3.7 8.6 0.3 5.4 5 1 0 5 5 5 0 WD domain, G-beta repeat RRM_1 PF00076.22 ORX66063.1 - 1.9e-22 78.8 0.0 2.1e-22 78.7 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX66063.1 - 5.6e-05 23.2 0.0 7.7e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 ORX66063.1 - 0.038 13.8 0.0 0.059 13.2 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif GST_C PF00043.25 ORX66064.1 - 2e-12 47.2 0.0 3.7e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX66064.1 - 1.9e-09 37.6 0.0 4.7e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX66064.1 - 3.9e-09 36.7 0.0 2.2e-08 34.3 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX66064.1 - 4.1e-09 36.3 1.6 1e-07 31.9 0.0 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX66064.1 - 2e-06 28.1 0.0 3.6e-05 24.1 0.0 2.4 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ORX66064.1 - 0.038 13.8 0.0 0.084 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX66064.1 - 0.1 13.0 0.0 0.31 11.4 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Ras PF00071.22 ORX66065.1 - 1e-09 38.2 0.1 2e-09 37.3 0.0 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ORX66065.1 - 4.8e-05 23.6 0.0 0.00012 22.3 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 ORX66065.1 - 0.018 14.7 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein Ras PF00071.22 ORX66066.1 - 4.3e-30 104.5 0.0 4.9e-30 104.3 0.0 1.0 1 0 0 1 1 1 1 Ras family MMR_HSR1_Xtn PF16897.5 ORX66066.1 - 0.00085 19.3 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 ORX66066.1 - 0.0035 17.3 0.0 0.0039 17.1 0.0 1.1 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 ORX66066.1 - 0.022 14.3 0.0 0.026 14.1 0.0 1.1 1 0 0 1 1 1 0 Ferrous iron transport protein B Roc PF08477.13 ORX66066.1 - 0.053 13.8 0.0 0.09 13.0 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66066.1 - 0.085 12.3 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family COG6 PF06419.11 ORX66067.1 - 3.9e-101 339.2 6.9 1.1e-99 334.4 6.9 2.0 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 Syntaxin-6_N PF09177.11 ORX66067.1 - 0.17 12.5 1.6 0.64 10.6 0.1 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.12 ORX66067.1 - 7.2 6.7 6.7 63 3.6 0.1 4.1 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Utp14 PF04615.13 ORX66068.1 - 3.3 6.2 37.3 4.6 5.7 37.3 1.3 1 0 0 1 1 1 0 Utp14 protein Mitofilin PF09731.9 ORX66068.1 - 8.7 5.0 26.7 11 4.6 26.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Pkinase PF00069.25 ORX66069.1 - 3.3e-64 216.8 0.0 3.9e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66069.1 - 1.7e-31 109.4 0.0 2.2e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX66069.1 - 0.0033 16.8 0.0 0.0066 15.8 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX66069.1 - 0.0053 15.6 0.1 0.0086 14.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX66069.1 - 0.036 13.4 0.1 0.057 12.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ORX66069.1 - 0.062 12.3 0.2 0.14 11.1 0.1 1.6 1 1 0 2 2 2 0 Poxvirus serine/threonine protein kinase Adeno_PIX PF03955.14 ORX66069.1 - 0.14 12.4 3.7 0.35 11.0 3.7 1.8 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) RskA PF10099.9 ORX66069.1 - 0.23 11.7 8.9 0.33 11.2 8.9 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA AAA PF00004.29 ORX66070.1 - 4.4e-42 143.6 0.0 1.1e-41 142.3 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ORX66070.1 - 2.8e-28 97.7 0.5 7.2e-28 96.4 0.1 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ORX66070.1 - 1.1e-23 83.1 8.4 2.5e-23 81.9 8.4 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 ORX66070.1 - 1.7e-07 30.9 0.0 9.2e-07 28.6 0.0 2.2 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 ORX66070.1 - 6.7e-06 26.6 0.1 0.00066 20.1 0.0 2.7 2 1 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 ORX66070.1 - 7.6e-06 26.2 0.1 0.0053 16.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX66070.1 - 2.9e-05 23.8 0.0 5.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ORX66070.1 - 4.6e-05 22.8 0.0 0.00016 21.0 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 ORX66070.1 - 4.9e-05 23.4 0.0 0.00018 21.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) USP8_dimer PF08969.11 ORX66070.1 - 6.2e-05 23.2 5.4 0.00013 22.2 5.4 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain RNA_helicase PF00910.22 ORX66070.1 - 6.5e-05 23.3 0.0 0.0087 16.4 0.0 3.3 3 1 1 4 4 3 1 RNA helicase AAA_22 PF13401.6 ORX66070.1 - 9.6e-05 22.7 0.2 0.018 15.3 0.0 2.8 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ORX66070.1 - 0.0001 22.1 0.0 0.00023 20.9 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 ORX66070.1 - 0.00038 19.7 0.0 0.0022 17.2 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ORX66070.1 - 0.00085 19.4 0.0 0.0026 17.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX66070.1 - 0.001 19.6 0.1 0.0047 17.5 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.6 ORX66070.1 - 0.0011 19.2 0.3 0.0033 17.6 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_17 PF13207.6 ORX66070.1 - 0.0046 17.4 1.2 0.047 14.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX66070.1 - 0.0061 16.3 0.5 0.028 14.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ORX66070.1 - 0.017 14.7 0.1 0.8 9.3 0.1 2.4 1 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ORX66070.1 - 0.027 14.4 1.0 1.1 9.1 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ORX66070.1 - 0.033 13.7 0.0 0.1 12.1 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 ORX66070.1 - 0.039 13.3 0.0 0.087 12.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 ORX66070.1 - 0.039 13.3 0.0 5.7 6.2 0.0 2.5 1 1 1 2 2 2 0 KaiC WASH_WAHD PF11945.8 ORX66070.1 - 0.049 13.1 0.2 0.081 12.4 0.2 1.2 1 0 0 1 1 1 0 WAHD domain of WASH complex Parvo_NS1 PF01057.17 ORX66070.1 - 0.052 12.6 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Use1 PF09753.9 ORX66070.1 - 0.057 13.1 1.3 0.11 12.2 1.3 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 PhdYeFM_antitox PF02604.19 ORX66070.1 - 0.068 13.0 0.5 0.46 10.3 0.1 2.6 2 1 1 3 3 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system NACHT PF05729.12 ORX66070.1 - 0.075 12.9 0.0 0.44 10.4 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ORX66070.1 - 0.13 12.0 0.0 0.46 10.2 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Torsin PF06309.11 ORX66070.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Torsin PhoH PF02562.16 ORX66070.1 - 0.13 11.6 1.3 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein TPR_1 PF00515.28 ORX66070.1 - 0.4 10.6 2.7 1.5 8.8 2.5 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX66070.1 - 0.46 10.7 2.6 1.5 9.1 1.0 2.7 2 1 1 3 3 2 0 Tetratricopeptide repeat PTR2 PF00854.21 ORX66071.1 - 1.3e-96 323.9 5.2 1.7e-96 323.5 5.2 1.1 1 0 0 1 1 1 1 POT family DUF5134 PF17197.4 ORX66071.1 - 0.064 13.2 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) DUF2104 PF09877.9 ORX66071.1 - 0.079 13.2 0.7 0.26 11.6 0.7 1.9 1 0 0 1 1 1 0 Predicted membrane protein (DUF2104) p450 PF00067.22 ORX66073.1 - 1.6e-58 198.6 0.0 2.2e-58 198.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rad52_Rad22 PF04098.15 ORX66074.1 - 1.8e-53 180.6 0.0 2.5e-53 180.1 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein mRNA_cap_enzyme PF01331.19 ORX66075.1 - 2.5e-50 171.0 0.1 3.2e-50 170.7 0.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ORX66075.1 - 4.2e-23 82.1 0.0 6.9e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ORX66075.1 - 5.5e-08 32.7 0.0 0.0012 18.5 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Chitin_synth_2 PF03142.15 ORX66076.1 - 2.8e-158 527.9 9.3 2.8e-158 527.8 6.6 1.9 2 0 0 2 2 2 1 Chitin synthase DEK_C PF08766.11 ORX66076.1 - 6e-18 64.5 0.1 3.8e-17 61.9 0.3 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 ORX66076.1 - 2.2e-10 40.8 9.6 7.6e-10 39.0 9.6 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX66076.1 - 1.3e-08 35.0 0.0 2.8e-08 34.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ORX66076.1 - 0.011 15.6 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Sugar_tr PF00083.24 ORX66078.1 - 6.2e-88 295.6 19.9 4.1e-87 292.9 19.9 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX66078.1 - 4e-23 81.9 66.4 2.3e-19 69.5 35.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4064 PF13273.6 ORX66078.1 - 0.023 15.0 3.3 0.023 15.0 3.3 4.4 3 3 1 4 4 4 0 Protein of unknown function (DUF4064) p450 PF00067.22 ORX66079.1 - 2.1e-60 204.8 0.0 1.2e-59 202.3 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 ORX66079.1 - 1.1e-23 84.0 0.0 4.9e-23 81.9 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ORX66079.1 - 1.1e-16 61.5 0.0 2.5e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 ORX66079.1 - 2.2e-05 24.7 0.4 0.23 11.7 0.1 2.7 1 1 1 2 2 2 2 Flavodoxin Abhydrolase_1 PF00561.20 ORX66080.1 - 1.2e-05 25.1 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX66080.1 - 9.3e-05 21.8 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX66080.1 - 0.0031 18.1 0.0 0.006 17.2 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family p450 PF00067.22 ORX66107.1 - 2e-50 171.9 0.0 3e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Transferase PF02458.15 ORX66108.1 - 1.4e-10 40.5 0.0 5.2e-09 35.3 0.0 2.7 1 1 0 1 1 1 1 Transferase family MIF PF01187.18 ORX66109.1 - 6.3e-10 39.4 0.0 7.4e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Sugar_tr PF00083.24 ORX66111.1 - 4.9e-74 249.8 29.6 4.2e-58 197.3 14.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX66111.1 - 1.5e-12 47.1 48.3 4.5e-08 32.4 8.5 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily Ninjurin PF04923.12 ORX66111.1 - 0.075 13.0 1.4 0.26 11.3 1.4 2.0 1 0 0 1 1 1 0 Ninjurin Gly-zipper_YMGG PF13441.6 ORX66111.1 - 3.6 7.4 9.8 2 8.2 2.9 3.5 2 2 0 2 2 2 0 YMGG-like Gly-zipper DUF1977 PF09320.11 ORX66112.1 - 2.2e-27 95.4 0.3 5.3e-27 94.1 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 ORX66112.1 - 2.4e-23 82.0 0.4 4e-23 81.3 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1356 PF07092.12 ORX66115.1 - 0.0042 16.4 0.2 0.0061 15.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Telomere_reg-2 PF10193.9 ORX66116.1 - 1.1e-08 35.4 0.0 5.4e-08 33.3 0.0 2.3 2 0 0 2 2 2 1 Telomere length regulation protein DUF2866 PF11065.8 ORX66116.1 - 0.37 10.8 1.1 2.1 8.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2866) Xpo1 PF08389.12 ORX66117.1 - 6.8e-11 42.4 0.0 0.00073 19.6 0.0 4.1 4 0 0 4 4 4 2 Exportin 1-like protein Arm PF00514.23 ORX66117.1 - 0.12 12.5 0.1 0.53 10.4 0.1 2.3 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX66117.1 - 0.17 12.5 5.4 4 8.1 0.4 4.4 4 0 0 4 4 4 0 HEAT-like repeat Glyco_hydro_18 PF00704.28 ORX66118.1 - 1.1e-61 209.3 0.8 1.3e-61 209.1 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 5_nucleotid_C PF02872.18 ORX66120.1 - 3.7e-30 105.2 0.0 7.1e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ORX66120.1 - 1.4e-05 25.7 0.6 7.9e-05 23.2 0.6 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Phage_sheath_1 PF04984.14 ORX66120.1 - 0.063 13.1 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Phage tail sheath protein subtilisin-like domain HTH_11 PF08279.12 ORX66120.1 - 0.082 12.9 0.4 0.17 11.9 0.4 1.5 1 0 0 1 1 1 0 HTH domain RGS PF00615.19 ORX66121.1 - 1.9e-06 28.1 0.3 1.7e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain 7tm_3 PF00003.22 ORX66121.1 - 0.00024 20.9 17.4 0.0016 18.2 17.4 2.0 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR CENP-B_dimeris PF09026.10 ORX66121.1 - 0.12 12.8 4.0 0.28 11.6 4.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FHA PF00498.26 ORX66122.1 - 1.5e-15 57.3 0.0 2.6e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ORX66122.1 - 2.2e-10 40.1 11.9 3.9e-10 39.3 11.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX66122.1 - 3.3e-09 36.9 11.4 5.7e-09 36.2 11.4 1.4 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 ORX66122.1 - 7.5e-05 23.0 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-rbx1 PF12678.7 ORX66122.1 - 0.001 19.3 7.3 0.0029 17.8 7.3 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX66122.1 - 0.0016 18.2 11.5 0.0028 17.5 11.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX66122.1 - 0.0046 16.8 12.9 0.0082 16.0 12.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX66122.1 - 0.09 12.8 4.7 0.24 11.5 4.7 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX66122.1 - 0.19 11.8 8.9 0.18 11.9 7.4 1.8 1 1 0 1 1 1 0 RING-type zinc-finger PHD PF00628.29 ORX66122.1 - 0.44 10.5 7.4 0.85 9.6 7.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 ORX66122.1 - 1.5 8.8 12.5 4.2 7.4 12.7 1.7 1 1 0 1 1 1 0 zinc-RING finger domain TPR_14 PF13428.6 ORX66123.1 - 9e-20 69.7 48.1 0.048 14.5 0.7 12.7 8 1 6 14 14 13 7 Tetratricopeptide repeat TPR_19 PF14559.6 ORX66123.1 - 9.4e-15 54.9 22.2 0.0001 22.7 0.4 8.4 5 1 1 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX66123.1 - 4.5e-09 36.8 32.9 0.087 13.5 0.1 8.2 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX66123.1 - 1.7e-06 27.7 8.2 3.9 7.8 0.0 9.3 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX66123.1 - 0.00045 20.3 25.6 0.006 16.7 1.0 5.6 3 2 3 6 6 6 2 Tetratricopeptide repeat Suf PF05843.14 ORX66123.1 - 0.0009 19.3 1.6 1.7 8.6 0.0 4.4 4 1 1 5 5 5 1 Suppressor of forked protein (Suf) ANAPC3 PF12895.7 ORX66123.1 - 0.0023 18.1 2.2 1.5 9.1 0.1 4.0 3 1 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ORX66123.1 - 0.0042 17.2 7.6 0.83 10.0 0.0 6.4 8 0 0 8 8 8 1 Tetratricopeptide repeat Thioredoxin_3 PF13192.6 ORX66123.1 - 0.077 13.1 0.2 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain TPR_12 PF13424.6 ORX66123.1 - 0.25 11.7 21.1 1.3 9.4 0.6 7.2 5 3 2 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX66123.1 - 0.41 10.8 4.7 2.7 8.2 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.10 ORX66123.1 - 0.83 8.6 5.4 0.28 10.2 0.2 2.5 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) PRP1_N PF06424.12 ORX66124.1 - 7.5e-42 143.2 5.0 9.4e-42 142.9 5.0 1.0 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal NuDC PF16273.5 ORX66124.1 - 3.2 8.3 12.1 0.13 12.8 5.8 1.9 2 0 0 2 2 2 0 Nuclear distribution C domain ThrE PF06738.12 ORX66125.1 - 5.8e-42 143.7 23.0 3.7e-37 128.0 5.5 2.0 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX66125.1 - 4.4e-12 46.3 27.5 3.5e-09 36.9 9.0 2.1 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE DUF2878 PF11086.8 ORX66125.1 - 0.0033 17.6 2.2 0.0033 17.6 2.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2878) DUF3493 PF11998.8 ORX66125.1 - 0.1 12.8 0.7 0.36 11.0 0.7 1.9 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 NKAP PF15692.5 ORX66126.1 - 2.2 9.0 6.7 4.8 8.0 1.7 2.6 2 0 0 2 2 2 0 NF-kappa-B-activating protein Myb_DNA-binding PF00249.31 ORX66127.1 - 1.3e-29 102.1 0.8 3.4e-12 46.3 0.1 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX66127.1 - 4.2e-20 71.7 3.0 2.5e-08 34.0 0.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 ORX66127.1 - 0.00046 20.2 0.0 0.39 10.8 0.0 3.1 3 0 0 3 3 3 2 SLIDE Rap1_C PF11626.8 ORX66127.1 - 0.011 15.8 0.1 0.025 14.7 0.1 1.6 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Peptidase_S9 PF00326.21 ORX66128.1 - 6.5e-23 81.3 0.1 1.9e-14 53.7 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ORX66128.1 - 3.5e-05 23.6 1.1 0.00032 20.4 0.1 2.2 2 0 0 2 2 2 1 Putative esterase Abhydrolase_6 PF12697.7 ORX66128.1 - 0.0012 19.5 3.6 0.0012 19.5 3.6 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX66128.1 - 0.0033 16.7 0.0 0.0048 16.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ORX66128.1 - 0.013 15.1 0.1 0.018 14.6 0.1 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 ORX66128.1 - 0.037 13.7 0.1 0.066 12.8 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 ORX66128.1 - 0.13 10.9 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) HMA PF00403.26 ORX66129.1 - 1.9e-06 28.2 3.6 1.3e-05 25.5 3.6 1.9 1 1 0 1 1 1 1 Heavy-metal-associated domain YtkA PF13115.6 ORX66129.1 - 0.099 13.3 0.1 0.13 12.9 0.1 1.1 1 0 0 1 1 1 0 YtkA-like Laminin_EGF PF00053.24 ORX66130.1 - 0.76 10.0 7.6 0.36 11.0 5.1 1.8 2 0 0 2 2 2 0 Laminin EGF domain Thymidylate_kin PF02223.17 ORX66131.1 - 1.3e-24 86.9 0.5 6.9e-19 68.2 0.5 3.0 1 1 0 1 1 1 1 Thymidylate kinase Methyltransf_3 PF01596.17 ORX66132.1 - 7.3e-24 84.1 0.2 6.7e-23 81.0 0.2 1.9 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX66132.1 - 9.7e-09 36.2 0.0 1.6e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX66132.1 - 0.0022 17.7 0.0 0.0029 17.3 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX66132.1 - 0.0038 17.8 0.0 0.0069 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ORX66132.1 - 0.14 11.7 0.1 0.2 11.2 0.1 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF1360 PF07098.11 ORX66132.1 - 0.87 9.6 4.8 1.6 8.7 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) Flu_M2 PF00599.17 ORX66133.1 - 0.019 15.1 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Influenza Matrix protein (M2) RSN1_7TM PF02714.15 ORX66134.1 - 5.9e-53 179.9 21.2 5.9e-53 179.9 21.2 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX66134.1 - 2.6e-30 105.2 4.0 2.6e-30 105.2 4.0 2.9 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX66134.1 - 1.7e-17 64.2 0.0 2.7e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 ORX66134.1 - 0.0079 16.0 0.1 0.89 9.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trypsin PF00089.26 ORX66135.1 - 1.4e-32 113.3 0.1 1.8e-32 112.9 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX66135.1 - 0.0022 18.9 0.1 0.0039 18.1 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ORX66136.1 - 1e-31 110.5 0.1 1.3e-31 110.2 0.1 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX66136.1 - 1.3e-09 39.2 0.9 1.6e-09 38.8 0.1 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain DUF3246 PF11596.8 ORX66136.1 - 0.0081 15.6 4.1 0.0081 15.6 4.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3246) FH2 PF02181.23 ORX66137.1 - 5.3e-90 302.2 2.5 5.3e-90 302.2 2.5 2.4 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ORX66137.1 - 1.1e-29 103.5 1.5 1.1e-29 103.5 1.5 3.3 2 2 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ORX66137.1 - 3.4e-27 95.2 0.1 3.4e-27 95.2 0.1 2.4 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain NleF_casp_inhib PF16809.5 ORX66137.1 - 0.015 15.2 0.1 3.1 7.7 0.3 2.9 2 0 0 2 2 2 0 NleF caspase inhibitor ANAPC4 PF12896.7 ORX66137.1 - 0.033 13.7 3.5 0.4 10.1 1.2 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 HD_5 PF13487.6 ORX66137.1 - 0.043 14.1 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 HD domain Baculo_PEP_C PF04513.12 ORX66137.1 - 0.3 11.1 6.8 3.2 7.8 6.2 2.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MADF_DNA_bdg PF10545.9 ORX66137.1 - 0.64 10.4 6.9 1.8 9.0 0.1 4.6 5 0 0 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF5082 PF16888.5 ORX66137.1 - 1.6 9.0 15.1 0.016 15.5 4.5 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF5082) Exonuc_VII_L PF02601.15 ORX66137.1 - 2.7 7.5 9.8 0.62 9.6 5.2 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ORX66137.1 - 3.3 7.0 23.3 0.0074 15.7 6.9 3.5 2 1 0 3 3 3 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 ORX66137.1 - 7.1 7.0 10.6 3.7 7.9 0.5 4.5 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Porin_3 PF01459.22 ORX66139.1 - 2.1e-65 220.9 4.4 2.4e-65 220.7 4.4 1.0 1 0 0 1 1 1 1 Eukaryotic porin Sugar_tr PF00083.24 ORX66140.1 - 4.4e-71 240.1 28.0 1.7e-69 234.9 28.0 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX66140.1 - 1.6e-20 73.3 57.2 1.4e-17 63.7 17.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 ORX66140.1 - 5.9e-05 21.7 8.9 0.0041 15.6 0.4 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector DUF4191 PF13829.6 ORX66140.1 - 0.39 10.0 0.0 0.39 10.0 0.0 2.9 2 1 2 4 4 4 0 Domain of unknown function (DUF4191) Na_H_Exchanger PF00999.21 ORX66141.1 - 3.3e-61 207.2 43.2 4.7e-61 206.7 43.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrbE PF11100.8 ORX66141.1 - 0.085 13.1 5.8 0.97 9.7 0.0 3.8 3 0 0 3 3 3 0 Conjugal transfer protein TrbE GcrA PF07750.11 ORX66142.1 - 0.016 15.6 1.7 0.021 15.3 1.7 1.1 1 0 0 1 1 1 0 GcrA cell cycle regulator Nucleoporin_N PF08801.11 ORX66143.1 - 5e-75 252.9 0.0 7.4e-75 252.3 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ORX66143.1 - 1.3e-23 83.6 0.5 6.5e-23 81.3 0.5 1.9 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal HAD_2 PF13419.6 ORX66146.1 - 2.2e-08 34.4 0.0 0.0028 17.8 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX66146.1 - 0.0051 17.1 0.2 2.2 8.5 0.1 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX66146.1 - 0.026 14.6 0.1 0.058 13.5 0.1 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like SNF2_N PF00176.23 ORX66147.1 - 5.7e-41 140.4 0.0 1.1e-40 139.5 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX66147.1 - 2.3e-15 56.9 0.0 1.5e-14 54.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Rad54_N PF08658.10 ORX66147.1 - 0.0032 17.6 0.0 0.0058 16.8 0.0 1.4 1 0 0 1 1 1 1 Rad54 N terminal HDA2-3 PF11496.8 ORX66147.1 - 0.0085 15.3 0.0 0.047 12.9 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ORX66147.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RasGEF PF00617.19 ORX66148.1 - 1.7e-32 113.0 0.1 4.8e-32 111.6 0.1 1.7 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX66148.1 - 2.4e-08 34.2 0.0 9.3e-08 32.3 0.0 2.1 3 0 0 3 3 3 1 RasGEF N-terminal motif DEAD PF00270.29 ORX66150.1 - 6.2e-46 156.4 0.0 9.4e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX66150.1 - 3.3e-18 66.1 0.1 2.4e-17 63.3 0.1 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX66150.1 - 9.4e-06 25.7 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ORX66150.1 - 0.00061 19.5 0.0 0.00098 18.8 0.0 1.2 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 ORX66150.1 - 0.019 15.2 0.0 0.056 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain DNA_pol_phi PF04931.13 ORX66150.1 - 0.055 11.6 0.6 0.08 11.0 0.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi SNF2_N PF00176.23 ORX66150.1 - 0.061 12.0 0.0 0.079 11.7 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain cEGF PF12662.7 ORX66151.1 - 0.039 13.9 0.5 0.1 12.6 0.5 1.8 1 0 0 1 1 1 0 Complement Clr-like EGF-like MIP PF00230.20 ORX66152.1 - 1.2e-09 38.3 5.8 5e-06 26.4 0.3 2.0 1 1 1 2 2 2 2 Major intrinsic protein ThrE PF06738.12 ORX66153.1 - 1.5e-58 198.0 23.0 2.8e-55 187.3 3.9 2.0 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX66153.1 - 1.4e-12 47.9 27.7 2.2e-09 37.5 10.7 2.4 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE DUF3339 PF11820.8 ORX66153.1 - 3.9 7.7 7.7 0.58 10.4 0.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3339) DEAD PF00270.29 ORX66154.1 - 3.8e-42 144.0 0.1 9.6e-42 142.7 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX66154.1 - 3.5e-22 78.8 0.0 1.4e-21 76.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX66154.1 - 2.6e-15 56.4 0.2 6.1e-15 55.2 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX66154.1 - 0.00025 21.1 1.3 0.00054 20.0 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ORX66154.1 - 0.051 13.9 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 ORX66154.1 - 0.079 12.5 0.1 0.079 12.5 0.1 2.8 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain Tim17 PF02466.19 ORX66155.1 - 0.0058 17.0 7.7 0.07 13.5 7.9 2.0 1 1 1 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family E1-E2_ATPase PF00122.20 ORX66156.1 - 1.1e-43 148.9 1.0 1.1e-43 148.9 1.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX66156.1 - 2.3e-21 77.0 0.2 1.8e-20 74.2 0.0 2.6 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX66156.1 - 3.9e-08 33.4 0.0 0.0027 17.5 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX66156.1 - 3e-05 24.5 0.0 5.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase MBOAT PF03062.19 ORX66157.1 - 7e-12 45.3 28.2 2e-09 37.3 14.4 3.1 1 1 1 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family CTP_transf_like PF01467.26 ORX66158.1 - 0.00015 22.0 0.0 0.00018 21.7 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 ORX66158.1 - 0.036 14.0 0.2 0.05 13.5 0.2 1.2 1 0 0 1 1 1 0 FAD synthetase DUF982 PF06169.12 ORX66159.1 - 0.027 14.5 0.6 4.4 7.4 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF982) Ribosomal_L19e PF01280.20 ORX66161.1 - 2.1e-55 186.8 7.3 2.1e-55 186.8 7.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L19e UPF0058 PF01893.16 ORX66161.1 - 0.046 14.0 1.0 0.046 14.0 1.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0058 DUF3301 PF11743.8 ORX66161.1 - 0.25 11.0 1.8 0.49 10.1 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) DUF5102 PF17104.5 ORX66162.1 - 0.24 11.4 8.9 0.19 11.7 2.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) HAD_2 PF13419.6 ORX66163.1 - 3.3e-19 69.7 0.0 5.5e-19 68.9 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX66163.1 - 1.7e-17 64.4 0.0 2.1e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX66163.1 - 5e-05 23.3 0.1 8.9e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 ORX66163.1 - 0.0042 16.9 0.0 0.031 14.1 0.0 2.0 2 0 0 2 2 2 1 Acid Phosphatase Hydrolase_6 PF13344.6 ORX66163.1 - 0.043 13.9 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Septin PF00735.18 ORX66164.1 - 1.1e-112 376.0 0.1 1.1e-112 376.0 0.1 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ORX66164.1 - 8.2e-08 32.3 1.5 1.6e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX66164.1 - 2.2e-06 27.8 2.4 0.0098 16.0 0.0 3.3 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 ORX66164.1 - 3.1e-05 23.4 0.0 3.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 ORX66164.1 - 0.0003 21.3 1.3 0.012 16.1 0.0 2.4 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ORX66164.1 - 0.00042 20.2 0.2 0.00042 20.2 0.2 3.0 3 1 0 3 3 3 1 RsgA GTPase AAA_24 PF13479.6 ORX66164.1 - 0.00046 20.0 1.0 0.01 15.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX66164.1 - 0.0026 18.0 0.0 0.011 16.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX66164.1 - 0.0026 18.1 0.2 0.0054 17.1 0.0 1.8 2 1 0 2 2 2 1 AAA ATPase domain Ras PF00071.22 ORX66164.1 - 0.0069 16.0 0.5 0.023 14.3 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ORX66164.1 - 0.01 16.0 0.3 0.027 14.7 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ORX66164.1 - 0.069 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ORX66164.1 - 0.071 13.5 0.4 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase FeoB_N PF02421.18 ORX66164.1 - 0.078 12.5 0.7 0.49 9.9 0.7 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.27 ORX66164.1 - 0.089 12.3 5.7 0.14 11.7 0.0 3.0 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 ORX66164.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TFIIF_beta_N PF17683.1 ORX66164.1 - 0.41 11.3 4.4 0.68 10.6 4.4 1.4 1 0 0 1 1 1 0 TFIIF, beta subunit N-terminus Strep_SA_rep PF06696.11 ORX66164.1 - 1.2 9.2 9.7 0.11 12.5 1.0 2.6 2 0 0 2 2 2 0 Streptococcal surface antigen repeat Exonuc_VII_L PF02601.15 ORX66164.1 - 1.4 8.4 7.1 2 7.9 7.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 ORX66164.1 - 1.8 7.6 7.2 2.6 7.1 7.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HLH PF00010.26 ORX66165.1 - 0.0033 17.4 0.3 0.0071 16.3 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Prok_Ub PF14454.6 ORX66165.1 - 0.0042 16.7 0.1 0.015 15.0 0.1 1.9 1 0 0 1 1 1 1 Prokaryotic Ubiquitin PTS_2-RNA PF01885.16 ORX66166.1 - 2.7e-53 180.7 0.0 3.8e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Rubella_E2 PF05749.11 ORX66166.1 - 6.4 6.2 8.0 29 4.0 0.0 2.1 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 WD40 PF00400.32 ORX66167.1 - 1.1e-65 216.0 14.5 7.4e-10 39.3 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66167.1 - 2.3e-26 91.9 0.0 3.3e-06 27.3 0.0 6.6 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 ORX66167.1 - 5e-25 87.6 5.8 5e-25 87.6 5.8 1.6 2 0 0 2 2 1 1 Tup N-terminal Ge1_WD40 PF16529.5 ORX66167.1 - 1.1e-09 37.8 0.0 1.8 7.4 0.0 6.0 2 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX66167.1 - 1.6e-09 37.6 0.0 0.015 14.6 0.0 4.2 3 1 1 4 4 4 3 WD40-like domain PD40 PF07676.12 ORX66167.1 - 1.3e-08 34.5 0.0 9.5 6.3 0.0 6.6 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ORX66167.1 - 2.1e-07 31.0 0.0 0.019 14.9 0.0 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX66167.1 - 9.1e-07 27.9 0.3 0.35 9.4 0.0 4.7 3 1 2 5 5 5 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ORX66167.1 - 0.0005 19.5 0.1 3.4 6.9 0.0 3.4 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ORX66167.1 - 0.0015 17.2 0.0 0.17 10.4 0.0 2.3 1 1 1 2 2 2 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 ORX66167.1 - 0.0019 17.8 0.1 3.6 7.1 0.0 3.2 2 1 1 3 3 3 1 PQQ-like domain SHE3 PF17078.5 ORX66167.1 - 0.0096 15.7 2.3 0.016 14.9 2.3 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Proteasome_A_N PF10584.9 ORX66167.1 - 0.013 15.2 5.0 79 3.1 0.4 5.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF3450 PF11932.8 ORX66167.1 - 0.015 14.6 1.9 0.015 14.6 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Frtz PF11768.8 ORX66167.1 - 0.02 13.2 0.0 0.5 8.6 0.0 2.8 2 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz ZapB PF06005.12 ORX66167.1 - 2.7 8.5 10.8 2.3 8.7 1.6 3.1 2 1 1 3 3 3 0 Cell division protein ZapB CAP PF00188.26 ORX66169.1 - 6.1e-13 49.7 0.7 7.5e-13 49.4 0.7 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family MIP PF00230.20 ORX66170.1 - 2.6e-36 125.4 11.7 3.4e-36 125.1 11.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein Na_Ca_ex PF01699.24 ORX66170.1 - 3.5 7.6 12.7 14 5.6 12.7 1.9 1 1 0 1 1 1 0 Sodium/calcium exchanger protein MIP PF00230.20 ORX66171.1 - 2.2e-37 129.0 9.6 2.9e-37 128.6 9.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein Asp-Al_Ex PF06826.12 ORX66171.1 - 0.003 17.4 1.0 0.003 17.4 1.0 2.7 2 2 0 2 2 2 1 Predicted Permease Membrane Region Esterase_phd PF10503.9 ORX66171.1 - 0.0098 15.4 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase MIP PF00230.20 ORX66172.1 - 2.2e-64 217.3 26.3 7.7e-35 120.6 9.9 2.1 2 0 0 2 2 2 2 Major intrinsic protein UPF0014 PF03649.13 ORX66172.1 - 0.0011 18.3 10.5 0.16 11.3 1.7 2.8 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0014) KRTAP7 PF15034.6 ORX66172.1 - 0.02 15.9 0.6 16 6.5 0.1 3.0 2 0 0 2 2 2 0 KRTAP type 7 family ChitinaseA_N PF08329.10 ORX66172.1 - 0.3 10.8 0.4 12 5.5 0.1 2.2 2 0 0 2 2 2 0 Chitinase A, N-terminal domain DUF2684 PF10885.8 ORX66172.1 - 0.32 11.1 2.0 23 5.2 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) DUF5363 PF17320.2 ORX66172.1 - 0.39 10.6 0.8 33 4.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5363) PIGA PF08288.12 ORX66173.1 - 1.8e-30 105.3 0.9 5.2e-29 100.7 0.9 2.6 1 1 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 ORX66173.1 - 4.8e-20 72.3 0.1 9e-20 71.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ORX66173.1 - 8.8e-15 55.3 0.1 5.3e-14 52.8 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ORX66173.1 - 8.6e-12 44.9 0.0 2.9e-11 43.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ORX66173.1 - 4.9e-05 23.8 0.0 0.0011 19.5 0.0 2.4 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ORX66173.1 - 0.00055 20.3 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 ANAPC4_WD40 PF12894.7 ORX66174.1 - 0.0013 19.0 0.0 0.0072 16.6 0.0 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain EPL1 PF10513.9 ORX66176.1 - 2.3e-25 89.8 0.0 5.1e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like Kelch_3 PF13415.6 ORX66177.1 - 2.3e-37 126.6 13.6 6.3e-09 35.9 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX66177.1 - 2.3e-32 110.4 12.5 4.6e-08 32.9 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 ORX66177.1 - 9.2e-31 105.2 8.2 1.4e-07 30.9 0.0 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ORX66177.1 - 2.2e-29 101.2 12.2 1.3e-07 31.5 0.2 5.9 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX66177.1 - 5e-27 93.3 9.8 2.4e-06 27.6 0.0 6.1 4 1 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ORX66177.1 - 8.4e-24 82.6 5.4 6.6e-05 22.7 0.0 6.1 6 0 0 6 6 6 5 Kelch motif PQQ_3 PF13570.6 ORX66177.1 - 0.054 14.0 12.1 1 10.0 0.2 4.4 5 1 0 5 5 5 0 PQQ-like domain Tetraspanin PF00335.20 ORX66180.1 - 2.5e-19 69.9 1.4 2.9e-19 69.7 1.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF1345 PF07077.11 ORX66180.1 - 0.089 12.5 0.2 0.24 11.1 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Tetraspanin PF00335.20 ORX66181.1 - 5.1e-07 29.6 0.1 6.4e-07 29.3 0.1 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF3533 PF12051.8 ORX66182.1 - 1.3e-23 83.5 4.8 1.2e-13 50.7 0.4 2.8 1 1 0 2 2 2 2 Protein of unknown function (DUF3533) DUF3377 PF11857.8 ORX66182.1 - 0.85 9.6 2.2 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF1240 PF06836.12 ORX66182.1 - 1.5 9.4 4.7 3.6 8.2 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) DUF3533 PF12051.8 ORX66183.1 - 1.7e-22 79.9 7.5 3.4e-17 62.4 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF3533) DUF4745 PF15923.5 ORX66183.1 - 0.038 14.0 1.2 0.075 13.0 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4745) NapE PF06796.11 ORX66183.1 - 0.26 10.8 2.3 2.1 8.0 0.1 3.0 3 0 0 3 3 3 0 Periplasmic nitrate reductase protein NapE Proteasome PF00227.26 ORX66184.1 - 7.9e-28 97.2 0.0 9.2e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit SNAPc_SNAP43 PF09808.9 ORX66185.1 - 1.8e-33 116.1 0.2 2.5e-33 115.6 0.2 1.2 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Histone PF00125.24 ORX66186.1 - 3.4e-41 140.7 1.4 6.1e-41 139.8 1.4 1.4 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX66186.1 - 0.00018 21.6 0.1 0.00041 20.4 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ORX66186.1 - 0.0043 17.3 0.2 0.03 14.6 0.1 2.3 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 ORX66186.1 - 0.025 14.9 0.1 0.045 14.1 0.1 1.4 1 0 0 1 1 1 0 CENP-S protein Cohesin_load PF10345.9 ORX66187.1 - 0.0017 16.9 0.1 0.0023 16.5 0.1 1.2 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 ORX66187.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX66187.1 - 0.026 15.3 0.4 11 7.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Sod_Cu PF00080.20 ORX66189.1 - 1.3e-48 164.8 6.4 1.5e-48 164.6 6.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) ACPS PF01648.20 ORX66190.1 - 1.6e-14 54.0 0.0 1.9e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 ORX66190.1 - 0.003 17.6 0.6 1.3 9.2 0.0 2.4 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase N-terminal domain R3H PF01424.22 ORX66191.1 - 9.9e-12 44.7 0.0 1.9e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 ORX66191.1 - 3.6e-05 23.7 18.1 3.6e-05 23.7 18.1 9.2 9 2 1 10 10 10 4 NF-X1 type zinc finger Coiled-coil_56 PF09813.9 ORX66192.1 - 2.2e-07 30.9 0.0 2.7e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Lipase_GDSL_2 PF13472.6 ORX66193.1 - 1.3e-27 97.3 0.0 1.8e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX66193.1 - 2.8e-19 69.9 0.0 3.9e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3040 PF11239.8 ORX66194.1 - 0.2 11.9 0.2 0.2 11.9 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) YlaC PF10777.9 ORX66194.1 - 0.33 10.8 6.0 7 6.5 1.2 2.6 2 0 0 2 2 2 0 Inner membrane protein YlaC DUF4097 PF13349.6 ORX66195.1 - 6.6e-08 32.2 0.2 6.7e-07 28.9 0.2 2.2 1 1 0 1 1 1 1 Putative adhesin Pilus_CpaD PF09476.10 ORX66195.1 - 0.0056 16.4 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) Tyrosinase PF00264.20 ORX66196.1 - 7.5e-13 49.3 4.3 6.8e-12 46.1 1.4 2.8 2 1 0 2 2 2 1 Common central domain of tyrosinase Kdo PF06293.14 ORX66196.1 - 0.063 12.6 0.1 0.13 11.5 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 ORX66196.1 - 6.1 6.7 10.4 0.61 10.0 5.7 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4097 PF13349.6 ORX66197.1 - 5.4e-22 78.4 3.8 2.8e-14 53.1 0.5 2.1 1 1 1 2 2 2 2 Putative adhesin Tyrosinase PF00264.20 ORX66198.1 - 3.3e-18 66.8 2.4 6e-18 65.9 2.4 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyrosinase PF00264.20 ORX66199.1 - 3.7e-27 96.1 8.4 5.4e-25 89.0 8.4 2.4 1 1 0 1 1 1 1 Common central domain of tyrosinase Tyrosinase PF00264.20 ORX66200.1 - 5.1e-28 98.9 10.7 5.3e-27 95.6 10.7 2.2 1 1 0 1 1 1 1 Common central domain of tyrosinase Tyrosinase PF00264.20 ORX66201.1 - 4.2e-25 89.3 7.4 4.2e-25 89.3 7.4 2.7 2 2 0 2 2 2 1 Common central domain of tyrosinase Tape_meas_lam_C PF09718.10 ORX66201.1 - 0.084 13.0 0.0 0.64 10.2 0.0 2.3 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4097 PF13349.6 ORX66202.1 - 1.9e-13 50.3 15.6 9.3e-07 28.4 5.3 2.2 1 1 1 2 2 2 2 Putative adhesin DUF4097 PF13349.6 ORX66203.1 - 1e-15 57.8 0.8 1.9e-09 37.3 3.1 2.1 1 1 1 2 2 2 2 Putative adhesin DUF4097 PF13349.6 ORX66204.1 - 3.5e-08 33.1 0.1 2.3e-07 30.4 0.0 2.2 2 1 0 2 2 2 1 Putative adhesin Glyco_hyd_65N_2 PF14498.6 ORX66204.1 - 0.055 13.3 0.9 0.12 12.2 0.9 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Evr1_Alr PF04777.13 ORX66205.1 - 2.6e-26 92.0 0.8 3e-26 91.8 0.8 1.1 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC4 PF18775.1 ORX66205.1 - 0.0062 16.7 0.2 0.011 15.9 0.2 1.6 1 1 0 1 1 1 1 APOBEC4 Pox_E10 PF04805.12 ORX66205.1 - 0.026 14.4 0.0 0.037 13.9 0.0 1.3 1 1 0 1 1 1 0 E10-like protein conserved region APOBEC1 PF18769.1 ORX66205.1 - 0.11 12.8 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 APOBEC1 Zn_ribbon_recom PF13408.6 ORX66205.1 - 0.14 12.7 2.2 0.93 10.1 2.2 2.0 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain FAD_SOX PF18371.1 ORX66205.1 - 0.14 12.5 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Creatinase_N_2 PF16189.5 ORX66206.1 - 5.6e-53 179.3 0.0 1.7e-52 177.8 0.0 1.9 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ORX66206.1 - 2.3e-42 145.1 0.0 3.8e-42 144.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ORX66206.1 - 1.8e-25 88.7 0.0 5.2e-25 87.3 0.0 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ORX66206.1 - 1e-20 74.8 0.0 2e-15 57.6 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_S10 PF00450.22 ORX66209.1 - 1.3e-109 367.4 0.1 1.6e-109 367.1 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Lipase PF00151.19 ORX66209.1 - 0.012 14.9 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Lipase Peptidase_S10 PF00450.22 ORX66210.1 - 3e-66 224.6 3.5 7.2e-34 117.9 3.2 4.2 1 1 1 2 2 2 2 Serine carboxypeptidase Peptidase_S9 PF00326.21 ORX66210.1 - 0.073 12.5 0.0 0.23 10.9 0.0 1.7 1 1 0 1 1 1 0 Prolyl oligopeptidase family Cu-oxidase_2 PF07731.14 ORX66211.1 - 4.6e-40 136.5 1.8 3.6e-35 120.7 0.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX66211.1 - 4.4e-36 123.5 3.2 3e-34 117.6 0.1 3.7 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX66211.1 - 1.1e-22 80.9 0.5 4.1e-20 72.5 0.0 3.2 2 1 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ORX66211.1 - 0.0029 17.7 0.0 6.7 6.9 0.0 3.3 3 2 0 3 3 3 2 Cupredoxin-like domain WD40 PF00400.32 ORX66212.1 - 6e-28 96.5 9.7 1.8e-05 25.4 0.3 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66212.1 - 1.6e-05 25.1 0.6 0.12 12.7 0.0 4.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ORX66212.1 - 0.00043 19.9 0.1 0.00099 18.8 0.1 1.8 1 0 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.5 ORX66212.1 - 0.0098 14.9 0.1 0.029 13.3 0.1 1.8 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX66212.1 - 0.028 13.1 1.0 5.4 5.5 0.1 3.6 2 1 2 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX66212.1 - 0.083 12.2 0.0 0.97 8.7 0.0 2.6 3 1 0 4 4 4 0 WD40-like domain EST1_DNA_bind PF10373.9 ORX66213.1 - 2.2e-12 47.0 0.4 6e-12 45.6 0.4 1.7 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 ORX66213.1 - 3.7e-10 40.6 0.0 3.7e-10 40.6 0.0 3.4 3 0 0 3 3 3 1 Telomerase activating protein Est1 Aminotran_4 PF01063.19 ORX66214.1 - 2.4e-17 63.6 0.0 3.2e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV E1-E2_ATPase PF00122.20 ORX66215.1 - 1.5e-49 168.0 1.4 3e-49 167.0 0.3 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 ORX66215.1 - 3.8e-19 68.6 0.0 8e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX66215.1 - 3.8e-15 56.8 0.3 1.8e-13 51.3 0.3 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX66215.1 - 2.5e-09 36.7 0.5 7.5e-09 35.2 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 ORX66215.1 - 7.4e-08 32.3 0.4 7.4e-08 32.3 0.4 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 ORX66215.1 - 7.3e-05 22.6 2.3 0.0079 16.0 0.6 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Nodulin-like PF06813.13 ORX66216.1 - 3.7e-07 29.9 4.7 5.2e-06 26.1 4.7 2.3 1 1 0 1 1 1 1 Nodulin-like Flavoprotein PF02441.19 ORX66217.1 - 6.7e-51 172.2 0.1 7.7e-51 172.0 0.1 1.0 1 0 0 1 1 1 1 Flavoprotein Voldacs PF03517.13 ORX66218.1 - 7.9e-30 103.8 3.3 1.2e-29 103.2 3.3 1.3 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Cathelicidins PF00666.17 ORX66218.1 - 0.074 13.4 0.1 0.22 11.9 0.0 1.7 2 0 0 2 2 2 0 Cathelicidin GRAM PF02893.20 ORX66218.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 GRAM domain MFS_1 PF07690.16 ORX66219.1 - 3.1e-28 98.7 36.8 4e-28 98.3 36.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 ORX66220.1 - 5.7e-21 74.8 38.7 3.5e-20 72.2 38.7 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Aldo_ket_red PF00248.21 ORX66223.1 - 1.7e-10 40.6 0.0 6e-09 35.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 ORX66224.1 - 2e-08 33.8 0.0 2.2e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PACT_coil_coil PF10495.9 ORX66224.1 - 0.15 12.7 0.0 0.29 11.7 0.0 1.4 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein BAF250_C PF12031.8 ORX66224.1 - 0.15 11.3 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa Aldo_ket_red PF00248.21 ORX66225.1 - 1.6e-74 250.8 0.0 1.8e-74 250.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.22 ORX66243.1 - 1.3e-17 63.4 0.0 3e-16 59.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lactococcin PF04369.13 ORX66243.1 - 0.14 12.4 1.4 0.22 11.7 1.4 1.3 1 0 0 1 1 1 0 Lactococcin-like family Pox_polyA_pol_N PF12630.7 ORX66243.1 - 0.14 12.5 0.1 1.1 9.7 0.0 2.0 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain EF_TS PF00889.19 ORX66245.1 - 5.7e-27 94.7 0.0 3.5e-23 82.3 0.0 2.3 1 1 1 2 2 2 2 Elongation factor TS UBA PF00627.31 ORX66245.1 - 0.043 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Formyl_trans_N PF00551.19 ORX66246.1 - 7.7e-52 175.6 0.0 8.9e-52 175.4 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase DTW PF03942.15 ORX66247.1 - 1.7e-31 109.5 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 DTW domain C1_2 PF03107.16 ORX66247.1 - 0.11 12.8 2.5 0.22 11.9 2.5 1.4 1 0 0 1 1 1 0 C1 domain F-box-like PF12937.7 ORX66248.1 - 0.12 12.3 0.0 2.5 8.1 0.0 2.5 2 0 0 2 2 2 0 F-box-like TPR_1 PF00515.28 ORX66249.1 - 1.6e-18 65.6 4.2 0.00057 19.6 0.3 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX66249.1 - 5.1e-15 54.9 4.7 4.4e-05 23.1 0.3 4.6 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.17 ORX66249.1 - 1.1e-12 47.1 7.4 0.005 16.9 0.5 5.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ORX66249.1 - 1.6e-12 46.9 4.9 0.014 15.7 0.1 5.2 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ORX66249.1 - 1.5e-11 44.1 6.0 0.0061 17.3 0.0 5.7 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX66249.1 - 8.1e-11 41.3 2.2 0.0057 16.8 0.2 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 ORX66249.1 - 4.9e-09 36.4 9.1 0.00047 20.4 0.2 5.3 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX66249.1 - 6.1e-09 36.4 3.5 0.0015 19.2 0.0 4.3 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX66249.1 - 3e-06 27.3 3.9 0.0038 17.3 1.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX66249.1 - 3e-06 27.7 10.1 0.089 13.3 0.1 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX66249.1 - 2.7e-05 24.4 7.1 1.2 9.5 2.3 4.0 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX66249.1 - 0.00018 21.3 2.5 0.62 10.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX66249.1 - 0.012 16.2 2.8 20 6.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1641 PF07849.11 ORX66249.1 - 0.032 14.1 0.1 0.065 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Fis1_TPR_C PF14853.6 ORX66249.1 - 0.092 12.8 0.5 2.8 8.1 0.1 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ORX66249.1 - 0.42 10.9 4.1 3.6 7.9 0.2 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 His_Phos_2 PF00328.22 ORX66250.1 - 4.6e-06 26.2 0.2 2.6e-05 23.8 0.2 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PLDc_2 PF13091.6 ORX66251.1 - 7.1e-28 97.1 0.3 1.2e-27 96.3 0.3 1.4 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 ORX66251.1 - 7.1e-07 29.0 1.6 0.0025 17.4 0.1 2.3 1 1 0 2 2 2 2 FAM83 A-H HA2 PF04408.23 ORX66252.1 - 5.2e-29 100.7 0.4 6.6e-28 97.1 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX66252.1 - 9.7e-16 57.9 0.0 2.4e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX66252.1 - 9.2e-12 45.3 0.0 1.4e-10 41.5 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DNA_pol_E_B PF04042.16 ORX66253.1 - 8.3e-21 74.3 0.3 2.9e-19 69.3 0.3 2.3 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 ORX66253.1 - 3.5e-14 53.4 1.3 2.1e-13 50.9 1.3 2.1 1 1 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal zf-C2H2_4 PF13894.6 ORX66254.1 - 0.022 15.6 0.3 0.022 15.6 0.3 2.4 3 0 0 3 3 3 0 C2H2-type zinc finger Actin_micro PF17003.5 ORX66254.1 - 0.15 11.2 0.6 0.17 11.0 0.6 1.2 1 0 0 1 1 1 0 Putative actin-like family Nsp3_PL2pro PF12124.8 ORX66254.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Coronavirus polyprotein cleavage domain TFIIS_C PF01096.18 ORX66255.1 - 5.1e-19 67.8 10.1 7.8e-19 67.3 10.1 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 ORX66255.1 - 1.5e-14 54.4 0.7 4.6e-14 52.8 0.0 2.0 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Med26 PF08711.11 ORX66255.1 - 2.4e-06 27.4 0.9 7.1e-06 26.0 0.9 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain FAM199X PF15814.5 ORX66255.1 - 0.15 11.1 2.7 0.23 10.5 2.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X zinc_ribbon_12 PF11331.8 ORX66255.1 - 0.94 9.3 3.4 22 5.0 0.3 2.4 2 0 0 2 2 2 0 Probable zinc-ribbon domain AAA PF00004.29 ORX66256.1 - 7.1e-72 240.0 0.0 5.6e-45 153.0 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 ORX66256.1 - 3.3e-08 33.8 0.0 0.00013 22.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX66256.1 - 4.2e-07 30.5 0.1 0.0013 19.1 0.1 3.3 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ORX66256.1 - 1.1e-06 28.5 0.0 2.9e-05 23.9 0.0 3.1 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 ORX66256.1 - 6.8e-06 25.8 1.4 4e-05 23.3 1.1 2.4 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 ORX66256.1 - 7.7e-06 26.2 0.1 0.12 12.6 0.1 3.8 3 1 1 4 4 4 2 AAA domain AAA_5 PF07728.14 ORX66256.1 - 2.3e-05 24.4 0.3 0.00047 20.2 0.1 3.3 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ORX66256.1 - 0.0012 18.8 0.0 0.0082 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX66256.1 - 0.005 17.0 0.0 0.017 15.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 ORX66256.1 - 0.0078 15.9 0.1 0.36 10.5 0.0 3.5 3 2 0 3 3 3 1 Sigma-54 interaction domain TIP49 PF06068.13 ORX66256.1 - 0.0095 15.2 0.0 0.021 14.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 ORX66256.1 - 0.011 15.4 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ORX66256.1 - 0.012 15.1 0.0 0.07 12.5 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ORX66256.1 - 0.035 14.7 0.0 0.075 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ORX66256.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 ORX66256.1 - 0.061 13.6 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX66256.1 - 0.067 13.7 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Parvo_NS1 PF01057.17 ORX66256.1 - 0.075 12.1 0.1 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 ORX66256.1 - 0.12 11.9 0.4 3.9 7.0 0.1 2.7 2 1 0 3 3 3 0 AAA domain AAA_7 PF12775.7 ORX66256.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region OrsD PF12013.8 ORX66257.1 - 7.8e-06 26.3 1.4 7.8e-06 26.3 1.4 2.3 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D adh_short PF00106.25 ORX66258.1 - 4.1e-23 81.9 0.1 7.9e-12 45.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66258.1 - 1.4e-13 51.0 0.1 1.3e-07 31.4 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX66258.1 - 0.1 12.5 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 KR domain Epimerase PF01370.21 ORX66258.1 - 0.15 11.5 0.1 0.21 11.0 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ORX66259.1 - 2.3e-25 89.2 0.0 7.8e-25 87.5 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66259.1 - 1.7e-18 67.1 0.0 5.4e-18 65.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Dimeth_Pyl PF09505.10 ORX66259.1 - 0.071 11.6 0.0 0.11 11.0 0.0 1.3 1 0 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) KR PF08659.10 ORX66259.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 KR domain Metallophos_2 PF12850.7 ORX66260.1 - 1.5e-19 70.8 0.0 1.9e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ORX66260.1 - 0.0045 17.5 0.1 0.012 16.1 0.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase adh_short PF00106.25 ORX66261.1 - 2.7e-27 95.5 0.0 3.8e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66261.1 - 4e-23 82.2 0.0 7.1e-23 81.4 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX66261.1 - 2.6e-08 34.0 0.0 3.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX66261.1 - 0.03 13.8 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX66261.1 - 0.13 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Calcipressin PF04847.12 ORX66262.1 - 3e-22 79.3 0.0 5.4e-22 78.4 0.0 1.5 1 1 0 1 1 1 1 Calcipressin ATP_bind_1 PF03029.17 ORX66263.1 - 2.9e-90 302.3 0.1 3.3e-90 302.1 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ORX66263.1 - 4e-05 23.5 0.0 0.00028 20.7 0.0 2.3 2 1 1 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 ORX66263.1 - 6.5e-05 22.7 0.0 0.00092 19.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX66263.1 - 0.00032 21.1 0.0 0.0017 18.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 ORX66263.1 - 0.00034 20.0 0.1 0.13 11.5 0.1 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_19 PF13245.6 ORX66263.1 - 0.00037 20.9 0.0 0.15 12.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ORX66263.1 - 0.0011 19.0 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ORX66263.1 - 0.0031 17.8 0.0 0.0078 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ORX66263.1 - 0.0081 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 ORX66263.1 - 0.01 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 ORX66263.1 - 0.014 15.4 0.0 0.08 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX66263.1 - 0.014 15.9 0.0 0.033 14.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ORX66263.1 - 0.015 15.1 0.3 3.4 7.4 0.0 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ORX66263.1 - 0.015 15.2 0.0 1.1 9.1 0.0 2.7 2 1 1 3 3 3 0 NTPase AAA_7 PF12775.7 ORX66263.1 - 0.016 14.8 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 ORX66263.1 - 0.019 14.5 0.1 0.45 10.0 0.1 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ORX66263.1 - 0.026 14.3 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX66263.1 - 0.027 14.9 0.0 0.26 11.7 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 ORX66263.1 - 0.028 13.8 0.0 0.066 12.6 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_10 PF12846.7 ORX66263.1 - 0.032 13.2 0.0 0.079 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain RNA_helicase PF00910.22 ORX66263.1 - 0.034 14.5 0.0 0.12 12.8 0.0 1.9 2 1 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ORX66263.1 - 0.034 14.7 0.0 0.073 13.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ORX66263.1 - 0.035 14.3 0.0 0.099 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_31 PF13614.6 ORX66263.1 - 0.036 14.0 0.0 6.8 6.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 ORX66263.1 - 0.049 13.7 0.0 0.07 13.2 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 ORX66263.1 - 0.059 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX66263.1 - 0.066 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Thymidylate_kin PF02223.17 ORX66263.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase MeaB PF03308.16 ORX66263.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ORX66263.1 - 0.12 12.3 0.1 4.4 7.2 0.0 2.7 2 1 1 3 3 3 0 RsgA GTPase ADK PF00406.22 ORX66263.1 - 0.14 12.2 0.4 1.1 9.3 0.0 2.2 2 1 0 2 2 2 0 Adenylate kinase AAA_29 PF13555.6 ORX66263.1 - 0.15 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IBN_N PF03810.19 ORX66264.1 - 1.6e-07 31.2 0.0 2.1e-05 24.4 0.0 3.2 3 1 1 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 ORX66264.1 - 0.0031 17.6 0.0 0.0098 16.0 0.0 1.9 1 0 0 1 1 1 1 Exportin 1-like protein HEAT PF02985.22 ORX66264.1 - 0.012 15.8 3.1 2.9 8.4 0.1 4.9 6 0 0 6 6 6 0 HEAT repeat DUF3535 PF12054.8 ORX66264.1 - 0.29 10.3 0.9 5.1 6.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3535) HEAT_EZ PF13513.6 ORX66264.1 - 4.5 7.9 10.2 1.3 9.6 0.3 4.8 4 1 2 6 6 6 0 HEAT-like repeat DNA_pol_phi PF04931.13 ORX66264.1 - 5.3 5.0 6.6 9.5 4.2 6.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Amidohydro_1 PF01979.20 ORX66265.1 - 2.7e-17 63.1 0.4 4.3e-17 62.5 0.4 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX66265.1 - 7.2e-07 29.0 0.1 2.8e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase family WD40_4 PF16300.5 ORX66266.1 - 1.4e-26 92.1 6.6 3.7e-13 49.1 0.8 2.9 2 1 1 3 3 3 2 Type of WD40 repeat DUF1899 PF08953.11 ORX66266.1 - 1e-08 34.9 0.0 7.5e-05 22.5 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 ORX66266.1 - 2.2e-07 31.1 0.0 0.022 15.0 0.0 4.3 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX66266.1 - 0.00028 21.6 12.7 0.18 12.7 0.0 6.5 8 0 0 8 8 8 1 WD domain, G-beta repeat IKI3 PF04762.12 ORX66266.1 - 0.00063 17.9 0.1 0.0022 16.1 0.0 1.8 2 0 0 2 2 2 1 IKI3 family RhoGEF PF00621.20 ORX66267.1 - 3.3e-13 50.3 0.1 2.3e-10 41.0 0.0 2.2 2 0 0 2 2 2 2 RhoGEF domain Alpha_E1_glycop PF01589.16 ORX66267.1 - 0.031 12.9 0.1 0.045 12.4 0.1 1.1 1 0 0 1 1 1 0 Alphavirus E1 glycoprotein SNF2_N PF00176.23 ORX66268.1 - 3.1e-74 249.8 0.6 7.9e-74 248.5 0.4 1.7 1 1 1 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 ORX66268.1 - 2.9e-36 124.0 0.1 1.4e-35 121.8 0.1 2.3 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 ORX66268.1 - 4.2e-35 120.9 3.5 4.2e-35 120.9 3.5 2.5 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 ORX66268.1 - 3.3e-20 72.5 0.0 1.3e-19 70.6 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX66268.1 - 1.5e-11 44.6 0.1 1e-10 41.9 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX66268.1 - 6.9e-05 22.7 0.0 0.00023 21.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ORX66268.1 - 0.00016 20.9 0.0 0.00051 19.3 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF1086 PF06461.11 ORX66268.1 - 0.00034 20.5 0.2 0.01 15.7 0.1 2.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1086) SWI2_SNF2 PF18766.1 ORX66268.1 - 0.00051 19.8 0.0 0.0019 17.9 0.0 2.0 1 1 0 1 1 1 1 SWI2/SNF2 ATPase DBINO PF13892.6 ORX66268.1 - 0.0012 19.2 0.0 0.0012 19.2 0.0 4.3 5 0 0 5 5 5 1 DNA-binding domain AAA_22 PF13401.6 ORX66268.1 - 0.0077 16.5 0.1 0.13 12.6 0.0 3.0 2 1 1 3 3 3 1 AAA domain ERCC3_RAD25_C PF16203.5 ORX66268.1 - 0.0078 15.5 0.2 0.035 13.3 0.2 2.0 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Myb_DNA-binding PF00249.31 ORX66268.1 - 0.037 14.2 0.1 22 5.3 0.0 3.2 2 1 0 2 2 2 0 Myb-like DNA-binding domain Skp1 PF01466.19 ORX66268.1 - 0.66 10.1 3.1 0.55 10.4 0.1 2.5 2 0 0 2 2 1 0 Skp1 family, dimerisation domain FAD_binding_3 PF01494.19 ORX66269.1 - 3.2e-07 29.9 0.3 4.9e-05 22.7 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain Ank PF00023.30 ORX66270.1 - 4.5e-12 45.8 0.6 0.00057 20.2 0.0 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ORX66270.1 - 1.2e-10 41.8 0.1 2.8e-10 40.7 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX66270.1 - 2.6e-10 40.6 0.1 2.1e-05 25.0 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX66270.1 - 2.4e-08 34.1 0.8 1.2e-05 25.4 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX66270.1 - 2.7e-07 30.3 0.2 0.0069 16.8 0.0 3.8 3 1 0 3 3 3 1 Ankyrin repeat Ser_hydrolase PF06821.13 ORX66270.1 - 0.12 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase DUF953 PF06110.11 ORX66272.1 - 1.8e-19 69.5 0.1 3e-19 68.8 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 ORX66272.1 - 0.0036 17.3 0.1 0.0053 16.7 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ORX66272.1 - 0.0082 15.9 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AAA PF00004.29 ORX66273.1 - 1.9e-32 112.4 0.2 3.5e-30 105.1 0.0 2.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX66273.1 - 2.8e-06 27.0 0.0 8.6e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain CDC48_N PF02359.18 ORX66273.1 - 2.9e-05 24.2 0.0 9.3e-05 22.5 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 ORX66273.1 - 0.0078 16.3 0.1 0.021 14.9 0.1 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) UDPGP PF01704.18 ORX66274.1 - 6.2e-185 614.7 0.3 1.1e-184 613.9 0.0 1.4 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase WBS_methylT PF12589.8 ORX66275.1 - 1.5e-18 67.3 0.6 2.5e-18 66.6 0.6 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 ORX66275.1 - 3.1e-09 37.3 0.0 1.7e-08 35.0 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX66275.1 - 5.4e-08 33.4 0.1 3.3e-07 30.9 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX66275.1 - 0.00026 20.9 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX66275.1 - 0.00052 20.7 0.0 0.0017 19.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ORX66275.1 - 0.026 14.9 0.0 0.057 13.7 0.0 1.7 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 ORX66275.1 - 0.055 13.3 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain tRNA_SAD PF07973.14 ORX66276.1 - 6.2e-08 32.6 0.2 1.3e-07 31.6 0.2 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 ORX66276.1 - 0.051 12.1 0.0 0.07 11.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (A) E1-E2_ATPase PF00122.20 ORX66277.1 - 1.2e-49 168.3 2.7 1.2e-49 168.3 2.7 3.1 3 1 2 5 5 5 1 E1-E2 ATPase Hydrolase PF00702.26 ORX66277.1 - 1.3e-21 77.9 0.1 3e-21 76.7 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX66277.1 - 9.7e-10 38.0 1.4 8.9e-09 34.9 0.1 2.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 ORX66277.1 - 0.00052 19.8 7.7 0.00052 19.8 7.7 2.5 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 ORX66277.1 - 0.00053 19.8 0.0 0.021 14.5 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SET PF00856.28 ORX66278.1 - 1e-21 78.0 0.5 1.2e-20 74.5 0.5 2.1 1 1 0 1 1 1 1 SET domain N-SET PF11764.8 ORX66278.1 - 0.0028 17.8 0.1 0.004 17.3 0.1 1.2 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N 6PF2K PF01591.18 ORX66280.1 - 4.4e-49 166.8 0.7 1e-47 162.3 0.7 2.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX66280.1 - 8.2e-22 77.8 0.3 8.8e-21 74.5 0.3 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ORX66280.1 - 0.05 13.8 0.2 0.22 11.7 0.2 2.2 1 1 0 1 1 1 0 AAA domain DUF4250 PF14056.6 ORX66280.1 - 0.099 12.6 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Na_Ca_ex PF01699.24 ORX66281.1 - 9.7e-46 155.5 44.4 1.5e-24 86.7 17.2 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein MSSP PF03940.13 ORX66282.1 - 6.8 6.4 12.1 1.3 8.7 8.3 1.8 1 1 1 2 2 2 0 Male specific sperm protein Metallophos_2 PF12850.7 ORX66283.1 - 0.0016 18.7 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ADH_N_2 PF16884.5 ORX66284.1 - 3.4e-20 72.0 0.0 6.5e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ORX66284.1 - 3.4e-13 49.7 0.6 7.2e-12 45.4 0.6 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX66284.1 - 0.00023 22.2 0.0 0.00045 21.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Chitin_synth_2 PF03142.15 ORX66285.1 - 6.3e-242 803.9 1.0 9.7e-242 803.2 1.0 1.3 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX66285.1 - 3.2e-125 419.0 0.0 2.6e-124 415.9 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 ORX66285.1 - 9.3e-13 47.9 0.1 5e-12 45.6 0.1 2.2 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX66285.1 - 1.4e-12 48.0 0.0 1.1e-10 41.8 0.0 3.2 3 0 0 3 3 3 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX66285.1 - 2.1e-12 47.4 3.0 2.1e-12 47.4 3.0 2.7 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 ORX66285.1 - 9.4e-10 38.5 0.5 2.9e-06 27.3 0.0 3.6 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 ORX66285.1 - 2e-06 27.7 0.0 0.0026 17.6 0.0 2.9 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX66285.1 - 0.00031 20.2 0.0 0.0011 18.4 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 21 Wzy_C PF04932.15 ORX66285.1 - 0.075 12.7 0.0 0.52 9.9 0.0 2.4 2 0 0 2 2 2 0 O-Antigen ligase Chitin_synth_2 PF03142.15 ORX66286.1 - 2.4e-248 825.0 0.6 3e-248 824.7 0.6 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX66286.1 - 1.3e-14 54.7 0.0 1.4e-13 51.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX66286.1 - 1.1e-13 51.6 5.5 1.1e-13 51.6 5.5 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 DEK_C PF08766.11 ORX66286.1 - 6.8e-12 45.1 0.0 5.7e-11 42.2 0.2 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glycos_transf_2 PF00535.26 ORX66286.1 - 2.1e-05 24.4 0.0 0.0037 17.1 0.0 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX66286.1 - 3.3e-05 23.4 0.1 0.0014 18.1 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 21 Cyt-b5 PF00173.28 ORX66286.1 - 0.053 13.7 0.1 0.53 10.5 0.0 2.5 3 0 0 3 3 3 0 Cytochrome b5-like Heme/Steroid binding domain adh_short PF00106.25 ORX66288.1 - 1.3e-14 54.2 0.0 1.8e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66288.1 - 1.1e-06 28.4 0.0 1.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_7 PF13241.6 ORX66288.1 - 0.047 14.1 0.1 0.087 13.3 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ORX66288.1 - 0.059 12.7 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 ORX66288.1 - 0.064 12.5 0.0 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 ORX66289.1 - 1.5e-19 70.2 47.3 3.6e-12 45.9 16.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily IncD PF17628.2 ORX66289.1 - 1.1 9.0 12.2 0.31 10.8 1.3 2.4 2 0 0 2 2 2 0 Inclusion membrane protein D VIT1 PF01988.19 ORX66289.1 - 1.5 8.6 17.9 2.1 8.1 3.8 3.0 2 1 1 3 3 3 0 VIT family Mito_carr PF00153.27 ORX66290.1 - 2.2e-60 200.6 0.6 7.4e-26 89.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX66290.1 - 0.00046 19.4 1.2 0.37 9.9 0.0 3.0 2 1 0 3 3 3 3 Gammaproteobacterial serine protease WD40 PF00400.32 ORX66291.1 - 1.7e-17 63.4 3.4 0.00015 22.5 0.0 4.9 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66291.1 - 3.4e-05 24.0 0.0 0.63 10.4 0.0 3.5 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX66291.1 - 0.036 12.7 0.2 0.82 8.2 0.0 2.3 1 1 0 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX66291.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.6 1 1 0 1 1 1 0 WD40-like domain TAP_C PF03943.13 ORX66292.1 - 2.4e-17 62.3 3.2 2.4e-17 62.3 3.2 1.8 2 0 0 2 2 2 1 TAP C-terminal domain RRM_9 PF18444.1 ORX66292.1 - 2.8e-17 62.3 0.0 5.7e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif LRR_4 PF12799.7 ORX66292.1 - 0.0013 19.1 1.4 0.0058 17.0 1.4 2.2 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX66292.1 - 0.053 13.3 3.0 0.54 10.1 3.0 2.6 1 1 0 1 1 1 0 Leucine rich repeat PKD_channel PF08016.12 ORX66293.1 - 0.0034 16.1 0.7 0.0041 15.8 0.7 1.0 1 0 0 1 1 1 1 Polycystin cation channel Lung_7-TM_R PF06814.13 ORX66293.1 - 0.0077 15.5 4.9 0.0095 15.2 4.9 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Ninjurin PF04923.12 ORX66293.1 - 0.05 13.5 3.4 0.073 13.0 3.4 1.2 1 0 0 1 1 1 0 Ninjurin FAD_binding_8 PF08022.12 ORX66293.1 - 0.065 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain EI24 PF07264.11 ORX66293.1 - 0.13 12.5 3.6 0.16 12.2 3.6 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) 7tm_1 PF00001.21 ORX66293.1 - 0.26 10.6 3.2 0.36 10.1 3.2 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Sid-5 PF17204.3 ORX66293.1 - 5 7.4 7.3 0.3 11.3 0.5 2.0 1 1 1 2 2 2 0 Sid-5 family zf-RING_2 PF13639.6 ORX66294.1 - 5.3e-14 52.3 10.1 5.3e-14 52.3 10.1 1.6 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX66294.1 - 9.6e-08 31.8 10.3 2.2e-07 30.6 10.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX66294.1 - 9.7e-08 31.6 5.8 1.9e-07 30.7 5.8 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX66294.1 - 1.2e-07 31.5 9.2 2.3e-07 30.6 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX66294.1 - 3.8e-06 26.8 7.6 3.8e-06 26.8 7.6 1.6 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ORX66294.1 - 1.5e-05 25.2 11.1 5.4e-05 23.4 11.1 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX66294.1 - 5e-05 23.2 6.4 0.00012 22.0 6.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX66294.1 - 7.2e-05 22.6 7.7 0.00014 21.7 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX66294.1 - 0.00025 20.9 7.8 0.00049 19.9 7.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ORX66294.1 - 0.0097 15.5 7.6 0.028 14.0 7.6 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX66294.1 - 0.061 13.5 7.9 0.17 12.1 7.9 1.8 1 1 0 1 1 1 0 RING-variant domain TMEM192 PF14802.6 ORX66294.1 - 0.13 11.3 0.0 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 TMEM192 family zf-ANAPC11 PF12861.7 ORX66294.1 - 0.18 11.9 8.9 1.7 8.8 8.9 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger S1FA PF04689.13 ORX66294.1 - 0.41 10.8 1.8 29 4.9 0.2 2.4 2 0 0 2 2 2 0 DNA binding protein S1FA FANCL_C PF11793.8 ORX66294.1 - 1.2 9.3 9.4 5.1 7.3 8.8 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain TarH PF02203.15 ORX66294.1 - 4.3 7.2 4.1 22 4.9 0.0 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue WD40 PF00400.32 ORX66295.1 - 9e-52 171.9 24.0 1.2e-05 25.9 0.0 11.8 10 1 1 11 11 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66295.1 - 3.5e-20 72.1 1.5 0.00093 19.5 0.0 8.8 6 3 3 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ORX66295.1 - 1.1e-17 64.3 0.5 1.9e-17 63.5 0.5 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 ORX66295.1 - 2.8e-06 26.5 0.5 0.8 8.6 0.0 4.9 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX66295.1 - 0.00072 18.3 2.6 8.2 4.9 0.0 4.9 4 1 1 5 5 5 1 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX66295.1 - 0.0045 16.9 0.0 0.93 9.3 0.0 3.5 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A SpoU_sub_bind PF08032.12 ORX66295.1 - 0.034 14.4 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding LTXXQ PF07813.12 ORX66295.1 - 0.082 13.6 0.2 0.082 13.6 0.2 3.5 3 1 1 4 4 4 0 LTXXQ motif family protein WD40_like PF17005.5 ORX66295.1 - 0.12 11.7 0.0 12 5.1 0.0 3.5 3 1 0 4 4 4 0 WD40-like domain Nucleoporin_N PF08801.11 ORX66295.1 - 0.25 10.0 0.0 1.8 7.2 0.0 2.2 2 1 0 3 3 3 0 Nup133 N terminal like PALB2_WD40 PF16756.5 ORX66295.1 - 0.81 8.5 5.1 2.3 7.1 0.6 3.0 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain CH PF00307.31 ORX66296.1 - 3.7e-16 59.3 0.0 6.3e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 ORX66296.1 - 0.18 11.4 1.4 0.36 10.5 1.4 1.4 1 0 0 1 1 1 0 Calponin family repeat DUF3526 PF12040.8 ORX66297.1 - 0.053 14.0 0.1 0.098 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) Sod_Cu PF00080.20 ORX66299.1 - 9.2e-18 64.8 0.5 1.4e-17 64.2 0.5 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) RhoGAP PF00620.27 ORX66301.1 - 1.6e-38 131.9 0.1 1.8e-38 131.8 0.1 1.0 1 0 0 1 1 1 1 RhoGAP domain Iso_dh PF00180.20 ORX66302.1 - 5.7e-87 292.1 0.1 6.9e-87 291.8 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Coatomer_WDAD PF04053.14 ORX66303.1 - 9.3e-161 535.8 0.0 1.9e-160 534.8 0.0 1.5 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 ORX66303.1 - 3.4e-28 97.3 0.5 0.00011 22.9 0.0 8.6 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66303.1 - 2.1e-07 31.1 0.1 0.58 10.5 0.0 6.3 4 3 3 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX66303.1 - 0.0072 15.7 0.0 0.42 9.9 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain Clathrin PF00637.20 ORX66303.1 - 0.0082 16.0 0.5 0.49 10.3 0.1 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS Nup160 PF11715.8 ORX66303.1 - 0.01 14.5 1.1 2.1 6.9 0.0 3.5 2 2 2 4 4 4 0 Nucleoporin Nup120/160 MatE PF01554.18 ORX66304.1 - 7.6e-30 103.7 24.4 3.1e-21 75.7 9.3 2.6 3 0 0 3 3 3 2 MatE zf-C4_ClpX PF06689.13 ORX66304.1 - 0.034 14.0 0.9 0.12 12.3 0.9 1.9 1 0 0 1 1 1 0 ClpX C4-type zinc finger MatE PF01554.18 ORX66305.1 - 1.8e-46 157.7 23.5 7.2e-25 87.5 6.5 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ORX66305.1 - 2.1 8.4 31.1 0.018 15.1 10.3 4.1 3 2 1 4 4 4 0 Polysaccharide biosynthesis C-terminal domain EXS PF03124.14 ORX66306.1 - 5.1e-65 220.0 0.7 6.1e-65 219.7 0.7 1.2 1 0 0 1 1 1 1 EXS family OMPdecase PF00215.24 ORX66307.1 - 1.1e-78 263.9 0.1 1.3e-78 263.7 0.1 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF2508 PF10704.9 ORX66307.1 - 0.12 12.6 0.2 0.24 11.6 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2508) DEAD PF00270.29 ORX66308.1 - 2.7e-37 128.2 0.0 6.7e-37 126.9 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX66308.1 - 2.6e-19 69.6 0.2 3.2e-17 62.9 0.7 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ORX66308.1 - 0.0064 15.9 0.6 0.19 11.0 0.0 2.2 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Carn_acyltransf PF00755.20 ORX66309.1 - 2.9e-173 577.7 0.3 3.7e-173 577.3 0.3 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PEX-2N PF09263.10 ORX66309.1 - 0.12 12.8 0.1 0.33 11.3 0.1 1.7 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal DUF4097 PF13349.6 ORX66310.1 - 0.00041 19.8 0.0 0.0012 18.2 0.0 1.7 1 1 0 1 1 1 1 Putative adhesin LIM PF00412.22 ORX66311.1 - 1e-22 80.1 34.1 2e-13 50.3 5.1 4.6 4 1 0 4 4 4 3 LIM domain DZR PF12773.7 ORX66311.1 - 4.3 7.4 28.6 0.15 12.1 1.2 4.7 2 1 0 2 2 2 0 Double zinc ribbon GATase_6 PF13522.6 ORX66312.1 - 4.5e-16 59.3 0.0 1e-15 58.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ORX66312.1 - 3.2e-13 49.7 0.0 7.4e-13 48.5 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ORX66312.1 - 2.5e-06 27.1 0.0 4.9e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ORX66312.1 - 0.00014 20.9 0.0 0.00028 19.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II TIM PF00121.18 ORX66313.1 - 2.2e-90 302.3 0.2 2.5e-90 302.1 0.2 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase zf-U1 PF06220.12 ORX66314.1 - 1.8e-13 50.0 2.3 2.8e-13 49.4 2.3 1.3 1 0 0 1 1 1 1 U1 zinc finger DAO PF01266.24 ORX66315.1 - 9.9e-40 137.2 0.0 4.2e-39 135.1 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX66315.1 - 0.00097 18.4 0.0 0.21 10.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX66315.1 - 0.11 12.5 0.0 8.1 6.4 0.0 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ORX66315.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RabGAP-TBC PF00566.18 ORX66316.1 - 1.6e-28 99.8 0.1 2e-28 99.5 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_S24 PF00717.23 ORX66318.1 - 4e-06 26.7 0.0 1.1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ORX66318.1 - 0.0005 19.9 0.0 0.031 14.1 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 KH_1 PF00013.29 ORX66319.1 - 1.4e-05 24.8 0.5 0.00013 21.8 0.0 2.4 2 1 0 2 2 2 1 KH domain SUIM_assoc PF16619.5 ORX66319.1 - 0.48 10.5 13.4 7.8 6.7 13.4 2.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 MatE PF01554.18 ORX66320.1 - 3.5e-43 147.1 26.3 5.5e-24 84.6 7.4 2.5 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX66320.1 - 0.0034 17.4 8.3 0.0034 17.4 8.3 3.9 2 1 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 ORX66321.1 - 1.7e-45 154.6 27.0 1.5e-23 83.3 4.5 2.7 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX66321.1 - 0.00016 21.8 7.7 0.00016 21.8 7.7 3.9 2 1 1 3 3 3 2 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 ORX66322.1 - 7.4e-49 165.5 26.4 9.9e-25 87.1 6.5 2.7 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX66322.1 - 5.8e-07 29.7 17.0 9.1e-06 25.8 0.6 4.0 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Exo_endo_phos_2 PF14529.6 ORX66323.1 - 7.6e-06 25.8 0.1 1.5e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase MatE PF01554.18 ORX66324.1 - 2.2e-50 170.4 33.0 7.4e-27 94.0 9.2 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX66324.1 - 0.00037 20.6 3.8 0.00037 20.6 3.8 4.0 4 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain UPF0242 PF06785.11 ORX66324.1 - 0.001 19.2 0.1 0.0019 18.3 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus MRP-L27 PF09809.9 ORX66325.1 - 9.7e-19 67.3 0.3 1.1e-18 67.2 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 NGP1NT PF08153.12 ORX66326.1 - 8.6e-52 174.7 0.2 2.2e-51 173.4 0.2 1.7 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 ORX66326.1 - 9.3e-17 61.2 0.0 3e-13 49.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX66326.1 - 1.3e-06 28.1 0.0 6.9e-06 25.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX66326.1 - 6.3e-05 22.9 0.0 0.00015 21.8 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 ORX66326.1 - 0.00028 20.5 0.0 1.4 8.4 0.0 3.1 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain BUD22 PF09073.10 ORX66326.1 - 0.0015 17.9 20.9 0.0025 17.3 20.9 1.2 1 0 0 1 1 1 1 BUD22 Arf PF00025.21 ORX66326.1 - 0.0079 15.7 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family AP3D1 PF06375.11 ORX66326.1 - 0.012 15.8 16.6 0.012 15.8 16.6 1.8 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Dynamin_N PF00350.23 ORX66326.1 - 0.1 12.6 9.3 0.85 9.6 0.0 4.7 3 3 1 4 4 4 0 Dynamin family AAA_16 PF13191.6 ORX66326.1 - 0.14 12.5 0.0 0.59 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain TLP-20 PF06088.11 ORX66326.1 - 6.2 6.7 13.4 12 5.8 1.9 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DAGK_cat PF00781.24 ORX66327.1 - 7.6e-21 74.0 0.0 1.3e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Glyco_transf_20 PF00982.21 ORX66328.1 - 3e-147 491.1 0.0 3.7e-147 490.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 AAA_18 PF13238.6 ORX66329.1 - 1.9e-05 25.2 0.0 0.00038 21.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX66329.1 - 0.00013 22.2 0.0 0.0011 19.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 ORX66329.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 ORX66329.1 - 0.02 14.6 0.0 0.032 14.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain tRNA_lig_kinase PF08303.11 ORX66329.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 tRNA ligase kinase domain APS_kinase PF01583.20 ORX66329.1 - 0.12 12.2 0.0 0.95 9.3 0.0 2.2 2 1 1 3 3 3 0 Adenylylsulphate kinase Peptidase_M16_C PF05193.21 ORX66330.1 - 6e-13 49.2 0.0 1.2e-07 32.0 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX66330.1 - 6.9e-06 26.1 0.0 1.8e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Sad1_UNC PF07738.13 ORX66331.1 - 3.8e-19 69.0 0.0 2.3e-11 43.8 0.0 2.3 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal LMBR1 PF04791.16 ORX66331.1 - 0.0034 16.4 0.0 0.0059 15.6 0.0 1.3 1 0 0 1 1 1 1 LMBR1-like membrane protein HOOK PF05622.12 ORX66331.1 - 0.02 13.1 12.4 0.029 12.6 12.4 1.1 1 0 0 1 1 1 0 HOOK protein Leu_zip PF15294.6 ORX66331.1 - 0.055 13.0 6.7 0.092 12.2 6.7 1.2 1 0 0 1 1 1 0 Leucine zipper YscO-like PF16789.5 ORX66331.1 - 0.076 13.1 11.2 0.15 12.1 11.2 1.4 1 0 0 1 1 1 0 YscO-like protein V_ATPase_I PF01496.19 ORX66331.1 - 0.16 9.9 2.1 0.24 9.3 2.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 ORX66331.1 - 0.22 11.6 19.6 0.66 10.0 9.0 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ORX66331.1 - 0.25 10.7 11.3 0.41 9.9 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ORX66331.1 - 0.88 8.4 13.0 1.4 7.7 13.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 ORX66331.1 - 1.2 8.6 7.3 2.1 7.8 7.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HAUS-augmin3 PF14932.6 ORX66331.1 - 1.5 8.3 12.1 2.7 7.5 12.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CENP-F_leu_zip PF10473.9 ORX66331.1 - 1.8 8.6 16.8 0.31 11.1 11.5 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spectrin PF00435.21 ORX66331.1 - 2.1 8.9 17.1 1.1 9.8 2.0 2.4 1 1 0 2 2 2 0 Spectrin repeat ADIP PF11559.8 ORX66331.1 - 3 7.9 18.1 1.3 9.1 12.5 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1216 PF06746.11 ORX66331.1 - 3 7.8 7.3 0.34 10.9 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) DUF724 PF05266.14 ORX66331.1 - 3.3 7.5 11.5 3 7.6 10.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FapA PF03961.13 ORX66331.1 - 5.4 5.5 9.7 3.2 6.3 7.3 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4061 PF13270.6 ORX66331.1 - 6.5 7.1 7.7 0.4 11.0 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) Spore_III_AB PF09548.10 ORX66331.1 - 7.3 6.7 9.5 16 5.6 9.5 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) TipAS PF07739.13 ORX66331.1 - 7.5 7.1 9.0 2 9.0 4.1 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain Occludin_ELL PF07303.13 ORX66331.1 - 7.7 7.3 12.8 0.55 11.0 6.1 2.1 2 0 0 2 2 2 0 Occludin homology domain OmpH PF03938.14 ORX66331.1 - 7.9 6.8 14.2 11 6.3 13.4 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FliJ PF02050.16 ORX66331.1 - 9 6.5 19.7 3.3 8.0 4.0 2.8 2 1 1 3 3 2 0 Flagellar FliJ protein KASH_CCD PF14662.6 ORX66331.1 - 9.3 6.0 16.4 24 4.7 14.8 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Macoilin PF09726.9 ORX66331.1 - 9.6 4.6 11.8 13 4.1 11.8 1.1 1 0 0 1 1 1 0 Macoilin family PRELI PF04707.14 ORX66336.1 - 1.6e-40 138.5 0.0 1.9e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family TFIIS_C PF01096.18 ORX66337.1 - 1.5e-18 66.3 2.8 1.5e-18 66.3 2.8 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX66337.1 - 4e-09 36.2 7.3 3.8e-06 26.7 0.3 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 ORX66337.1 - 6.9e-06 26.0 6.6 0.0027 17.7 0.4 2.6 2 1 0 2 2 2 2 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 ORX66337.1 - 0.00099 19.0 8.6 0.0044 17.0 0.2 3.2 2 1 1 3 3 3 1 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 ORX66337.1 - 0.0013 18.2 11.9 0.2 11.2 1.3 2.9 2 1 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX66337.1 - 0.0019 18.3 14.7 0.4 10.8 0.1 4.4 3 1 2 5 5 5 1 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 ORX66337.1 - 0.0031 17.4 3.6 0.064 13.1 0.1 2.7 2 1 1 3 3 3 1 Domain found in IF2B/IF5 zf-RING_7 PF02591.15 ORX66337.1 - 0.0047 17.1 0.1 0.1 12.8 0.0 3.3 4 0 0 4 4 3 2 C4-type zinc ribbon domain IBR PF01485.21 ORX66337.1 - 0.0055 16.9 7.0 0.074 13.3 0.2 2.8 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain GATA PF00320.27 ORX66337.1 - 0.0088 15.6 2.9 1.3 8.7 0.0 3.4 3 1 0 3 3 3 1 GATA zinc finger OrfB_Zn_ribbon PF07282.11 ORX66337.1 - 0.011 15.6 6.8 0.42 10.6 0.2 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 ORX66337.1 - 0.02 14.6 15.4 2.8 7.8 3.6 3.8 3 1 0 3 3 3 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ORX66337.1 - 0.021 14.3 17.5 0.76 9.3 3.8 4.0 3 1 0 3 3 3 0 zinc-ribbon domain DUF35_N PF12172.8 ORX66337.1 - 0.029 14.2 9.9 1.7 8.6 0.2 3.9 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_9 PF14369.6 ORX66337.1 - 0.034 14.4 8.6 2.3 8.5 0.1 4.1 4 0 0 4 4 4 0 zinc-ribbon Lar_restr_allev PF14354.6 ORX66337.1 - 0.038 14.4 8.7 0.42 11.0 1.0 2.9 2 1 0 2 2 2 0 Restriction alleviation protein Lar NOB1_Zn_bind PF08772.11 ORX66337.1 - 0.041 14.1 6.5 5.7 7.2 0.0 3.6 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like zf-TFIIB PF13453.6 ORX66337.1 - 0.049 13.0 8.1 0.2 11.0 0.7 2.6 2 1 0 2 2 2 0 Transcription factor zinc-finger zf-C4pol PF14260.6 ORX66337.1 - 0.052 14.0 2.3 3.6 8.1 0.0 2.3 1 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zf-RRN7 PF11781.8 ORX66337.1 - 0.055 13.2 8.9 4.5 7.0 3.2 4.1 3 1 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DpnI PF06044.12 ORX66337.1 - 0.069 12.8 3.8 0.65 9.6 0.3 2.1 1 1 0 2 2 2 0 Dam-replacing family RecR PF02132.15 ORX66337.1 - 0.072 12.7 0.9 0.072 12.7 0.9 2.7 3 0 0 3 3 3 0 RecR protein C1_1 PF00130.22 ORX66337.1 - 0.072 13.0 3.8 1 9.3 0.1 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TackOD1 PF18551.1 ORX66337.1 - 0.11 12.2 5.1 0.89 9.2 0.5 2.4 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Ogr_Delta PF04606.12 ORX66337.1 - 0.14 12.2 0.6 0.14 12.2 0.6 2.9 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2_12 PF18658.1 ORX66337.1 - 0.15 11.7 0.2 0.68 9.6 0.0 2.0 1 1 1 2 2 2 0 Zinc-finger C2H2-type zf-IS66 PF13005.7 ORX66337.1 - 0.18 12.3 9.6 1.7 9.1 0.1 3.8 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 Prok-RING_1 PF14446.6 ORX66337.1 - 0.2 11.6 9.5 0.18 11.8 1.0 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Terminase_GpA PF05876.12 ORX66337.1 - 0.27 9.7 3.0 0.47 8.9 0.4 2.1 1 1 1 2 2 2 0 Phage terminase large subunit (GpA) zinc_ribbon_4 PF13717.6 ORX66337.1 - 0.44 10.5 7.2 19 5.3 0.1 4.0 4 0 0 4 4 4 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 ORX66337.1 - 0.44 10.6 9.1 2 8.5 0.6 3.1 2 2 1 3 3 3 0 zinc-ribbons DNA_ligase_ZBD PF03119.16 ORX66337.1 - 0.47 10.5 6.5 2.3 8.3 1.1 3.0 3 0 0 3 3 2 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_ribbon_recom PF13408.6 ORX66337.1 - 0.59 10.7 6.5 14 6.3 0.7 3.3 3 1 0 3 3 3 0 Recombinase zinc beta ribbon domain zf-C2H2_3 PF13878.6 ORX66337.1 - 0.69 9.8 7.9 19 5.2 0.3 3.8 4 0 0 4 4 4 0 zinc-finger of acetyl-transferase ESCO zf-RING_5 PF14634.6 ORX66337.1 - 0.93 9.5 8.7 6.4 6.8 3.7 3.5 3 1 0 3 3 3 0 zinc-RING finger domain zf-ISL3 PF14690.6 ORX66337.1 - 1.1 10.0 7.5 8.3 7.2 0.0 3.5 4 0 0 4 4 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-H2C2_2 PF13465.6 ORX66337.1 - 1.3 9.6 10.0 1.1 9.8 0.4 3.7 4 0 0 4 4 4 0 Zinc-finger double domain A2L_zn_ribbon PF08792.10 ORX66337.1 - 1.4 8.8 13.9 23 4.9 0.2 4.1 4 0 0 4 4 4 0 A2L zinc ribbon domain XPA_N PF01286.18 ORX66337.1 - 1.4 9.0 7.6 24 5.1 0.3 3.4 3 0 0 3 3 3 0 XPA protein N-terminal Zn_Tnp_IS1 PF03811.13 ORX66337.1 - 1.5 8.7 0.0 1.5 8.7 0.0 3.0 4 0 0 4 4 3 0 InsA N-terminal domain zf_UBZ PF18439.1 ORX66337.1 - 2.4 7.8 9.5 43 3.8 0.5 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-Mss51 PF13824.6 ORX66337.1 - 2.4 8.3 11.9 3.5 7.8 3.0 3.1 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C4_Topoisom PF01396.19 ORX66337.1 - 3.6 7.5 13.5 10 6.0 5.7 3.6 3 1 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger PHD PF00628.29 ORX66337.1 - 3.9 7.5 9.8 0.31 11.0 0.5 2.9 2 1 1 3 3 3 0 PHD-finger Baculo_LEF5_C PF11792.8 ORX66337.1 - 4.7 7.0 7.7 0.3 10.8 1.6 2.3 2 1 0 2 2 1 0 Baculoviridae late expression factor 5 C-terminal domain YhfH PF14149.6 ORX66337.1 - 6.1 6.9 12.5 18 5.4 0.4 4.0 4 0 0 4 4 4 0 YhfH-like protein Ribosomal_L37e PF01907.19 ORX66337.1 - 7.2 6.9 9.5 17 5.7 0.1 3.8 3 1 0 3 3 3 0 Ribosomal protein L37e Auto_anti-p27 PF06677.12 ORX66337.1 - 8.8 6.6 12.5 2.9 8.1 1.2 3.1 2 2 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PhnA_Zn_Ribbon PF08274.12 ORX66337.1 - 9.5 6.3 13.5 19 5.3 0.0 3.8 3 1 0 3 3 3 0 PhnA Zinc-Ribbon Cpn60_TCP1 PF00118.24 ORX66338.1 - 8.6e-152 506.2 2.0 9.8e-152 506.0 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPT PF07931.12 ORX66338.1 - 0.028 14.3 1.2 0.3 10.9 0.2 2.7 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Gpr1_Fun34_YaaH PF01184.19 ORX66341.1 - 6.1e-09 35.8 3.5 7.1e-09 35.6 3.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family BCS1_N PF08740.11 ORX66342.1 - 1.8e-42 145.4 1.3 5.2e-42 143.9 1.3 1.7 1 1 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ORX66342.1 - 4.8e-21 75.5 0.0 8.4e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX66342.1 - 0.00036 21.0 0.1 0.0035 17.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 ORX66342.1 - 0.00074 20.1 0.0 0.0021 18.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 ORX66342.1 - 0.00091 19.0 0.0 0.012 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ORX66342.1 - 0.0035 17.7 0.0 0.011 16.2 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ORX66342.1 - 0.0039 17.3 0.0 0.012 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX66342.1 - 0.0043 17.0 0.0 0.012 15.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX66342.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 ORX66342.1 - 0.016 15.2 0.0 0.14 12.0 0.0 2.1 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_29 PF13555.6 ORX66342.1 - 0.02 14.6 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Polyoma_lg_T_C PF06431.11 ORX66342.1 - 0.022 13.7 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus TbpB_B_D PF01298.18 ORX66342.1 - 0.029 14.8 0.1 0.057 13.8 0.1 1.5 1 0 0 1 1 1 0 C-lobe and N-lobe beta barrels of Tf-binding protein B ATPase PF06745.13 ORX66342.1 - 0.037 13.4 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_21 PF13304.6 ORX66342.1 - 0.037 13.8 0.0 0.083 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 ORX66342.1 - 0.049 13.5 0.1 0.31 11.0 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 ORX66342.1 - 0.064 12.8 0.0 0.21 11.1 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 ORX66342.1 - 0.073 13.6 0.1 0.47 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ORX66342.1 - 0.073 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX66342.1 - 0.075 13.3 0.2 0.28 11.5 0.0 2.0 2 1 0 2 2 1 0 AAA domain DUF815 PF05673.13 ORX66342.1 - 0.077 12.1 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 ORX66342.1 - 0.079 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX66342.1 - 0.084 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 ORX66342.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX66342.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 ORX66342.1 - 0.17 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 ORX66342.1 - 0.19 10.7 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region HNH_5 PF14279.6 ORX66343.1 - 0.027 14.3 0.3 0.052 13.4 0.3 1.7 1 1 0 1 1 1 0 HNH endonuclease Sod_Fe_C PF02777.18 ORX66346.1 - 2.5e-34 117.5 0.2 4.2e-34 116.8 0.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ORX66346.1 - 3.7e-32 110.6 1.5 7.4e-32 109.7 1.5 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF3742 PF12553.8 ORX66347.1 - 3.2 7.9 5.0 1.6 8.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3742) Peptidase_M48 PF01435.18 ORX66348.1 - 6e-37 127.3 0.0 9.9e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 SIR2 PF02146.17 ORX66350.1 - 7.3e-36 123.7 0.0 1.1e-22 80.9 0.0 2.1 1 1 1 2 2 2 2 Sir2 family zf-Di19 PF05605.12 ORX66350.1 - 0.062 13.6 0.6 4.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ribosomal_60s PF00428.19 ORX66352.1 - 2.2 8.9 10.9 0.14 12.7 3.1 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein 4HBT PF03061.22 ORX66353.1 - 0.0075 16.6 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT PF03061.22 ORX66354.1 - 1e-09 38.6 0.1 1.5e-09 38.1 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily YiiD_C PF09500.10 ORX66354.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Putative thioesterase (yiiD_Cterm) MaoC_dehydratas PF01575.19 ORX66354.1 - 0.066 12.8 0.1 0.09 12.3 0.1 1.2 1 0 0 1 1 1 0 MaoC like domain Acyl-ACP_TE PF01643.17 ORX66354.1 - 0.077 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Acyl-ACP thioesterase CDP-OH_P_transf PF01066.21 ORX66355.1 - 5.5e-16 59.1 0.1 5.5e-16 59.1 0.1 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PBP PF01161.20 ORX66355.1 - 1.2e-14 54.7 0.0 2.5e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Sre PF03125.18 ORX66355.1 - 1.8 7.6 12.2 5.4 6.1 11.9 1.8 1 1 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor Asp PF00026.23 ORX66356.1 - 1.6e-70 238.0 0.0 2e-70 237.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX66356.1 - 1e-11 45.4 0.8 1.9e-09 38.0 0.7 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX66356.1 - 0.032 14.9 0.0 1.5 9.5 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease Asp PF00026.23 ORX66357.1 - 3e-72 243.7 0.0 7.8e-46 156.9 0.1 2.9 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX66357.1 - 2.7e-05 24.5 1.0 0.00019 21.7 0.1 2.5 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX66357.1 - 0.00029 21.4 0.0 0.064 13.9 0.0 2.4 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX66357.1 - 0.03 14.9 0.0 0.21 12.2 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease FA_desaturase PF00487.24 ORX66358.1 - 2.6e-25 89.7 17.0 3.5e-25 89.3 17.0 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Phosphodiest PF01663.22 ORX66359.1 - 1.2e-09 38.3 2.0 2e-06 27.7 0.3 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase RACo_linker PF17650.1 ORX66359.1 - 0.015 15.1 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 RACo linker region MFS_1 PF07690.16 ORX66360.1 - 2.2e-35 122.2 50.1 4.4e-27 94.9 28.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX66360.1 - 1.3e-09 37.4 27.9 2.9e-07 29.7 10.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter RibD_C PF01872.17 ORX66360.1 - 0.019 14.8 0.1 0.031 14.1 0.1 1.3 1 0 0 1 1 1 0 RibD C-terminal domain DUF3573 PF12097.8 ORX66360.1 - 0.54 9.0 3.3 2.2 7.0 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3573) Peptidase_M48_N PF16491.5 ORX66360.1 - 1.3 8.8 8.8 0.14 12.0 1.0 2.7 3 0 0 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices Cullin PF00888.22 ORX66361.1 - 1.5e-162 542.4 0.0 2.1e-162 542.0 0.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX66361.1 - 6.6e-21 74.1 0.7 2.4e-20 72.3 0.7 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.10 ORX66361.1 - 0.047 13.5 0.2 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain RabGAP-TBC PF00566.18 ORX66362.1 - 3.7e-38 131.4 7.8 1.2e-37 129.6 7.8 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 ORX66362.1 - 6.1e-09 35.6 0.0 2e-08 33.9 0.0 1.9 1 1 0 1 1 1 1 Rab-binding domain (RBD) ABC_tran PF00005.27 ORX66363.1 - 1.5e-30 106.5 0.0 2.2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX66363.1 - 1.3e-06 28.0 0.0 0.0011 18.5 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX66363.1 - 0.0027 17.8 0.0 0.006 16.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX66363.1 - 0.0052 16.5 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 ORX66363.1 - 0.0054 15.9 0.0 0.0084 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) FKBP_N_2 PF18023.1 ORX66363.1 - 0.034 14.3 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 BDBT FKBP like N-terminal T2SSE PF00437.20 ORX66363.1 - 0.034 13.2 0.0 0.067 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF87 PF01935.17 ORX66363.1 - 0.046 13.8 0.0 0.092 12.8 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_21 PF13304.6 ORX66363.1 - 0.066 13.0 0.0 0.95 9.2 0.1 2.1 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 ORX66363.1 - 0.066 13.2 0.2 14 5.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ORX66363.1 - 0.15 11.8 0.1 1.2 8.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_tran PF00005.27 ORX66364.1 - 7e-18 65.5 0.0 3e-17 63.4 0.0 1.9 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX66364.1 - 2.2e-07 30.5 0.1 0.0066 15.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX66364.1 - 0.003 17.3 0.0 0.0064 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 ORX66364.1 - 0.0079 16.3 0.2 0.011 15.8 0.2 1.2 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ORX66364.1 - 0.0081 16.2 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX66364.1 - 0.01 15.8 0.3 0.028 14.3 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 ORX66364.1 - 0.03 13.9 0.3 0.44 10.1 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ORX66364.1 - 0.051 14.0 0.1 0.072 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 ORX66364.1 - 0.058 13.2 0.2 0.49 10.2 0.1 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX66364.1 - 0.093 13.2 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ORX66364.1 - 0.13 11.4 0.1 0.4 9.8 0.1 1.7 1 1 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 ORX66364.1 - 0.16 11.2 0.1 1.2 8.4 0.1 2.0 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 ORX66365.1 - 5.1e-33 114.3 0.0 3.3e-28 98.7 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX66365.1 - 2.9e-16 59.0 1.7 9.2e-09 35.0 0.6 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX66365.1 - 0.00015 22.2 0.1 0.0056 17.1 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX66365.1 - 0.00094 19.5 0.0 0.012 15.9 0.0 2.7 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 ORX66365.1 - 0.0014 18.4 0.0 0.0051 16.6 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ORX66365.1 - 0.0039 17.0 0.0 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 ORX66365.1 - 0.0064 16.4 0.0 0.018 15.0 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 ORX66365.1 - 0.009 15.6 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX66365.1 - 0.014 15.2 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX66365.1 - 0.015 15.6 0.0 0.037 14.4 0.0 1.6 1 1 1 2 2 2 0 RNA helicase TIP49 PF06068.13 ORX66365.1 - 0.048 12.9 0.0 0.074 12.2 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 ORX66365.1 - 0.063 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ORX66365.1 - 0.064 13.8 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX66365.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ORX66365.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_2 PF07724.14 ORX66365.1 - 0.12 12.4 0.0 0.37 10.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 ORX66365.1 - 0.12 12.8 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Cytidylate_kin PF02224.18 ORX66365.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase PDZ_5 PF17817.1 ORX66366.1 - 0.0011 19.2 0.9 0.0024 18.1 0.6 1.7 1 1 0 1 1 1 1 PDZ domain Lipase_3 PF01764.25 ORX66369.1 - 4.8e-36 123.7 0.0 6.6e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 ORX66369.1 - 0.0056 16.2 0.0 0.0083 15.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 ORX66369.1 - 0.0079 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 ORX66369.1 - 0.029 14.1 0.0 0.055 13.2 0.0 1.4 1 1 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 ORX66369.1 - 0.061 13.9 0.1 0.12 12.9 0.1 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 ORX66369.1 - 0.14 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF915 PF06028.11 ORX66369.1 - 0.22 10.8 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) VHS PF00790.19 ORX66370.1 - 1.6e-30 105.8 0.0 1.6e-30 105.8 0.0 2.6 3 0 0 3 3 3 1 VHS domain FYVE PF01363.21 ORX66370.1 - 1.7e-16 60.1 14.0 1.7e-16 60.1 14.0 2.1 2 0 0 2 2 2 1 FYVE zinc finger UIM PF02809.20 ORX66370.1 - 0.0001 22.0 5.1 0.0001 22.0 2.2 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif Hrs_helical PF12210.8 ORX66370.1 - 0.0058 17.1 0.1 0.012 16.1 0.1 1.5 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate GAT PF03127.14 ORX66370.1 - 0.086 13.2 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 GAT domain Phg_2220_C PF09524.10 ORX66370.1 - 0.16 12.0 0.0 0.68 10.0 0.0 2.0 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) DUF4404 PF14357.6 ORX66370.1 - 4.7 7.9 6.5 41 4.9 2.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Band_7 PF01145.25 ORX66371.1 - 5.9e-26 91.6 5.2 9.2e-26 90.9 4.9 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 ORX66371.1 - 0.00093 18.3 1.2 0.0012 18.0 1.2 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial Myosin-VI_CBD PF16521.5 ORX66371.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Myosin VI cargo binding domain RNA_pol_Rpb1_5 PF04998.17 ORX66372.1 - 6.3e-109 363.5 0.3 1e-108 362.8 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 ORX66372.1 - 4.4e-108 361.3 0.0 7.4e-108 360.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 ORX66372.1 - 3.9e-77 258.1 0.1 9e-77 257.0 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 ORX66372.1 - 7.3e-67 224.9 1.0 1.3e-66 224.1 1.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 ORX66372.1 - 4.2e-49 166.0 6.0 7.9e-49 165.1 6.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 ORX66372.1 - 6.1e-37 125.9 0.3 1.8e-36 124.3 0.3 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 ORX66372.1 - 2.9e-33 115.0 0.0 1.3e-30 106.4 0.0 2.7 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_R PF05001.13 ORX66372.1 - 3.1e-12 46.2 398.0 0.47 10.9 16.4 19.1 6 1 24 32 32 32 27 RNA polymerase Rpb1 C-terminal repeat DUF4019 PF13211.6 ORX66372.1 - 0.14 12.6 0.1 0.33 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4019) zf-C4pol PF14260.6 ORX66372.1 - 0.24 11.9 1.8 0.66 10.5 1.8 1.8 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta 4HBT PF03061.22 ORX66374.1 - 3.2e-08 33.8 0.0 5.1e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily HAMP_N3 PF18575.1 ORX66374.1 - 0.0097 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 HAMP N-terminal domain 3 PEX11 PF05648.14 ORX66375.1 - 5.3e-30 104.5 0.2 6e-30 104.4 0.2 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Y_phosphatase2 PF03162.13 ORX66376.1 - 1.3e-42 145.2 0.0 3.9e-32 111.1 0.0 2.0 1 1 1 2 2 2 2 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX66376.1 - 0.0013 18.8 0.0 0.002 18.2 0.0 1.4 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX66376.1 - 0.047 13.3 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase HA2 PF04408.23 ORX66377.1 - 1.5e-20 73.5 0.1 1.5e-20 73.5 0.1 3.3 3 1 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX66377.1 - 2.1e-20 72.9 0.0 4.6e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX66377.1 - 2.6e-12 47.1 0.1 1.2e-11 45.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX66377.1 - 8.6e-07 28.9 0.0 2.6e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX66377.1 - 6.5e-05 23.2 0.2 0.00049 20.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX66377.1 - 0.00052 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX66377.1 - 0.0025 18.2 0.1 0.0066 16.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX66377.1 - 0.011 16.2 3.2 0.29 11.7 0.1 3.1 1 1 1 2 2 2 0 ABC transporter T2SSE PF00437.20 ORX66377.1 - 0.012 14.7 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein PWI PF01480.17 ORX66377.1 - 0.016 15.5 0.0 0.041 14.2 0.0 1.8 1 0 0 1 1 1 0 PWI domain AAA_7 PF12775.7 ORX66377.1 - 0.019 14.5 0.1 0.05 13.1 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region PFU PF09070.11 ORX66377.1 - 0.022 15.0 0.4 0.05 13.9 0.4 1.5 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) PhoH PF02562.16 ORX66377.1 - 0.038 13.4 0.1 0.079 12.4 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Pox_E10 PF04805.12 ORX66377.1 - 0.059 13.2 0.9 0.12 12.3 0.2 1.8 2 0 0 2 2 1 0 E10-like protein conserved region cobW PF02492.19 ORX66377.1 - 0.072 12.7 0.2 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ORX66377.1 - 0.14 12.5 0.0 0.14 12.5 0.0 3.0 3 1 0 3 3 1 0 AAA ATPase domain SRP54 PF00448.22 ORX66377.1 - 0.17 11.5 0.5 0.49 10.0 0.5 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ORX66377.1 - 0.18 12.0 2.5 0.23 11.6 0.0 2.6 2 0 0 2 2 1 0 AAA domain AAA_29 PF13555.6 ORX66377.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 ORX66377.1 - 0.2 11.7 6.9 0.25 11.3 0.1 3.3 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 ORX66377.1 - 0.23 11.0 3.9 1.9 8.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ORX66377.1 - 0.42 10.5 1.6 0.63 9.9 0.0 2.0 3 0 0 3 3 2 0 RsgA GTPase Syntaxin-18_N PF10496.9 ORX66378.1 - 6.2e-11 42.4 2.0 1.5e-10 41.1 0.1 2.4 2 1 1 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 ORX66378.1 - 3e-05 23.9 0.1 7.1e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 SNARE domain CENP-H PF05837.12 ORX66378.1 - 0.21 12.0 6.7 0.39 11.1 2.8 2.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) FUSC PF04632.12 ORX66378.1 - 0.4 9.2 5.0 0.092 11.3 0.7 1.8 1 1 0 2 2 2 0 Fusaric acid resistance protein family DUF2408 PF10303.9 ORX66378.1 - 3.4 8.2 9.4 1e+02 3.4 9.5 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) tRNA-synt_2b PF00587.25 ORX66379.1 - 9.9e-40 136.4 0.0 1.6e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX66379.1 - 4.6e-15 55.5 0.1 9.1e-15 54.6 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 ORX66379.1 - 5.3e-05 23.2 0.0 0.00015 21.8 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Cache_3-Cache_2 PF17201.4 ORX66379.1 - 0.046 13.0 0.0 0.083 12.1 0.0 1.3 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain UvsW PF11637.8 ORX66379.1 - 0.14 12.2 0.2 2.9 8.1 0.0 2.5 2 0 0 2 2 2 0 ATP-dependant DNA helicase UvsW DNA_methylase PF00145.17 ORX66380.1 - 1.4e-38 133.1 0.0 1.7e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Sld5 PF05916.11 ORX66381.1 - 2e-07 31.5 0.0 3e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein DUF952 PF06108.12 ORX66381.1 - 0.0057 16.6 0.0 0.015 15.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF952) TCTP PF00838.17 ORX66382.1 - 4.2e-71 238.6 0.4 4.7e-71 238.5 0.4 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Pterin_bind PF00809.22 ORX66382.1 - 0.026 14.2 0.2 0.057 13.1 0.1 1.6 1 1 1 2 2 2 0 Pterin binding enzyme Peptidase_M16_M PF16187.5 ORX66383.1 - 1.2e-42 146.1 0.1 1.3e-41 142.7 0.1 2.4 1 1 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ORX66383.1 - 7.6e-33 113.6 0.0 2e-32 112.3 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX66383.1 - 2.8e-18 66.6 0.0 4.1e-11 43.2 0.0 3.6 4 1 0 4 4 4 2 Peptidase M16 inactive domain Dynamin_N PF00350.23 ORX66384.1 - 9.7e-45 152.6 0.0 3.3e-44 150.9 0.0 1.9 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 ORX66384.1 - 1.6e-16 60.4 0.8 3.8e-15 55.9 0.1 2.9 3 0 0 3 3 3 1 Dynamin central region MMR_HSR1 PF01926.23 ORX66384.1 - 5.7e-06 26.4 0.0 1.4e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ORX66384.1 - 0.017 15.7 0.4 1.9 9.0 0.0 3.1 2 1 0 2 2 2 0 ABC transporter PduV-EutP PF10662.9 ORX66384.1 - 0.029 14.1 0.0 3.6 7.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.6 ORX66384.1 - 0.029 14.1 0.0 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 ORX66384.1 - 0.032 14.0 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX66384.1 - 0.096 12.4 0.1 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.13 ORX66384.1 - 0.13 12.5 0.0 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase UCR_hinge PF02320.16 ORX66385.1 - 4.4e-23 81.2 5.5 4.4e-23 81.2 5.5 1.7 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein DUF2052 PF09747.9 ORX66385.1 - 0.015 15.4 9.2 0.018 15.2 9.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Tim54 PF11711.8 ORX66385.1 - 0.22 10.3 4.1 0.22 10.2 4.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Spore_coat_CotO PF14153.6 ORX66385.1 - 0.35 10.8 9.1 0.38 10.7 9.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DREPP PF05558.12 ORX66385.1 - 0.64 9.9 15.8 0.78 9.6 15.8 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide DUF740 PF05340.12 ORX66385.1 - 0.92 8.2 8.3 1.1 8.0 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) TRAP_alpha PF03896.16 ORX66385.1 - 0.95 8.6 6.6 1 8.5 6.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NA37 PF04245.13 ORX66385.1 - 0.95 8.9 7.0 1.3 8.4 7.0 1.2 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein Paf1 PF03985.13 ORX66385.1 - 1.3 7.9 11.4 1.4 7.8 11.4 1.1 1 0 0 1 1 1 0 Paf1 CX9C PF16860.5 ORX66385.1 - 1.7 8.7 7.2 2.9 8.0 0.6 2.3 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CDC45 PF02724.14 ORX66385.1 - 2.8 6.1 8.9 3 6.0 8.9 1.0 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ORX66385.1 - 5.3 5.5 11.6 5.6 5.4 11.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ORX66385.1 - 6 4.8 13.5 6.4 4.8 13.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop53 PF07767.11 ORX66385.1 - 6.6 6.0 12.1 7.6 5.8 12.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) 7tm_3 PF00003.22 ORX66386.1 - 5.3e-07 29.6 26.4 7.5e-07 29.1 26.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Ubie_methyltran PF01209.18 ORX66409.1 - 8.3e-33 113.7 0.0 1e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ORX66409.1 - 2.1e-17 63.6 0.0 3.3e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX66409.1 - 7.1e-17 61.8 0.0 1.2e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX66409.1 - 2.1e-14 53.6 0.0 2.7e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX66409.1 - 2.3e-12 47.1 0.0 3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX66409.1 - 2.3e-10 41.1 0.0 3.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 ORX66409.1 - 0.00043 19.9 0.0 0.002 17.7 0.0 1.8 1 1 1 2 2 2 1 MraW methylase family Methyltransf_8 PF05148.15 ORX66409.1 - 0.0025 17.7 0.0 0.0069 16.3 0.0 1.6 1 1 0 2 2 2 1 Hypothetical methyltransferase N6_N4_Mtase PF01555.18 ORX66409.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 DNA methylase RrnaAD PF00398.20 ORX66409.1 - 0.18 10.8 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Sugar_tr PF00083.24 ORX66410.1 - 1.6e-17 63.5 3.9 2e-17 63.2 3.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX66410.1 - 5.5e-09 35.4 5.5 6.2e-09 35.2 5.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1275 PF06912.11 ORX66410.1 - 6e-05 23.1 1.7 7.6e-05 22.7 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) MFS_4 PF06779.14 ORX66410.1 - 0.003 16.9 1.3 0.0038 16.6 1.3 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB DUF2398 PF09661.10 ORX66410.1 - 0.0063 15.8 0.0 0.0077 15.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2398) Gly-zipper_YMGG PF13441.6 ORX66410.1 - 0.015 15.0 1.8 0.44 10.3 0.1 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper LapA_dom PF06305.11 ORX66410.1 - 0.067 13.0 0.2 0.067 13.0 0.2 2.3 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain Ribonuclease_T2 PF00445.18 ORX66412.1 - 4.4e-30 105.3 0.3 5.8e-30 104.9 0.3 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family PRP38_assoc PF12871.7 ORX66413.1 - 0.087 13.4 0.5 0.087 13.4 0.5 3.1 3 0 0 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Peptidase_M16_C PF05193.21 ORX66414.1 - 0.0058 16.7 0.0 0.0088 16.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Rrp44_CSD1 PF17216.3 ORX66415.1 - 0.15 11.8 0.1 0.19 11.5 0.1 1.1 1 0 0 1 1 1 0 Rrp44-like cold shock domain Peptidase_M16 PF00675.20 ORX66416.1 - 4.5e-10 39.7 0.0 8.2e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX66416.1 - 2.1e-05 24.6 0.0 7.8e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M28 PF04389.17 ORX66417.1 - 1.5e-32 112.9 0.3 3e-32 111.9 0.1 1.6 2 1 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX66417.1 - 1.1e-08 35.0 0.0 1.9e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Nicastrin PF05450.15 ORX66417.1 - 0.058 12.8 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Nicastrin Adap_comp_sub PF00928.21 ORX66418.1 - 4.6e-75 252.4 0.0 5.8e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX66418.1 - 7.1e-05 22.8 0.1 0.00012 22.0 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ORX66418.1 - 0.0002 20.9 0.4 0.0026 17.3 0.1 2.1 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain G-patch_2 PF12656.7 ORX66419.1 - 2.4e-12 46.7 0.3 5.2e-12 45.7 0.3 1.6 1 0 0 1 1 1 1 G-patch domain Lipase_3 PF01764.25 ORX66420.1 - 4.8e-24 84.8 0.1 2.8e-23 82.4 0.1 1.8 1 1 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 ORX66420.1 - 0.00097 18.5 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DUF2974 PF11187.8 ORX66420.1 - 0.0025 17.4 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX66420.1 - 0.0027 18.3 0.9 0.0049 17.5 0.7 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX66420.1 - 0.0039 16.5 0.0 0.0061 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF5345 PF17280.2 ORX66421.1 - 0.97 9.4 0.0 0.97 9.4 0.0 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5345) VPS28 PF03997.12 ORX66422.1 - 2.9e-64 216.2 2.6 3.3e-64 216.0 2.6 1.0 1 0 0 1 1 1 1 VPS28 protein DMAP_binding PF06464.11 ORX66422.1 - 0.092 13.6 0.0 0.17 12.7 0.0 1.6 1 0 0 1 1 1 0 DMAP1-binding Domain TerB_N PF13208.6 ORX66422.1 - 0.1 12.3 0.4 0.18 11.5 0.1 1.5 1 1 1 2 2 2 0 TerB N-terminal domain SGBP_B_XBD PF18329.1 ORX66423.1 - 0.0033 17.4 6.9 0.14 12.1 0.9 2.1 1 1 1 2 2 2 2 Surface glycan-binding protein B xyloglucan binding domain Pheromone PF08015.11 ORX66423.1 - 0.012 16.7 9.8 0.35 11.9 0.4 3.2 1 1 2 3 3 3 0 Fungal mating-type pheromone DUF4453 PF14627.6 ORX66423.1 - 0.02 15.0 0.4 6 7.0 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4453) EFP PF01132.20 ORX66423.1 - 0.065 13.3 0.0 16 5.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain Med17 PF10156.9 ORX66425.1 - 2.2e-22 79.4 0.9 6e-22 78.0 0.9 1.6 1 1 0 1 1 1 1 Subunit 17 of Mediator complex CDC45 PF02724.14 ORX66426.1 - 1.4e-158 529.1 0.6 8e-158 526.6 0.6 1.9 1 1 0 1 1 1 1 CDC45-like protein B277 PF17623.2 ORX66427.1 - 0.82 8.7 3.3 1.1 8.3 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function WD40 PF00400.32 ORX66428.1 - 3.8e-44 147.8 15.7 4.6e-08 33.6 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box PF00646.33 ORX66428.1 - 1.8e-10 40.4 0.4 3.4e-10 39.5 0.4 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX66428.1 - 2e-10 40.4 0.1 4.3e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ORX66428.1 - 1e-07 31.0 6.1 0.29 9.7 0.1 5.6 3 1 3 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ORX66428.1 - 9.2e-07 29.1 0.7 2.2 8.6 0.0 5.1 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 ORX66428.1 - 0.00033 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 F-box WD40_like PF17005.5 ORX66428.1 - 0.025 13.9 0.1 8 5.7 0.0 2.9 2 1 1 3 3 3 0 WD40-like domain PALB2_WD40 PF16756.5 ORX66428.1 - 0.23 10.4 6.4 6.1 5.7 0.1 3.2 3 2 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ORX66428.1 - 0.41 10.2 3.2 1.3 8.5 0.3 2.6 2 1 0 2 2 2 0 PQQ-like domain Kelch_6 PF13964.6 ORX66428.1 - 1.3 9.4 3.2 13 6.3 0.0 3.8 4 0 0 4 4 4 0 Kelch motif PQQ PF01011.21 ORX66428.1 - 2.6 8.1 7.5 7.3 6.7 0.9 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat DUF3402 PF11882.8 ORX66429.1 - 1.1e-08 34.7 0.0 2.3e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) Transferase PF02458.15 ORX66430.1 - 2.7e-18 65.9 0.0 1.6e-13 50.1 0.0 2.1 2 0 0 2 2 2 2 Transferase family Transferase PF02458.15 ORX66431.1 - 0.069 11.8 0.0 0.079 11.6 0.0 1.1 1 0 0 1 1 1 0 Transferase family Hydrolase_4 PF12146.8 ORX66432.1 - 5.7e-11 42.1 0.2 9.8e-11 41.4 0.2 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX66432.1 - 1.8e-09 37.6 0.3 1.2e-08 34.9 0.2 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX66432.1 - 1.7e-08 35.4 0.6 2.1e-08 35.0 0.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ORX66432.1 - 0.0018 17.9 0.0 0.0047 16.6 0.0 1.6 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ORX66432.1 - 0.011 15.2 0.6 1.2 8.5 0.2 2.5 2 1 1 3 3 3 0 Prolyl oligopeptidase family BAAT_C PF08840.11 ORX66432.1 - 0.073 13.0 0.0 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 ORX66432.1 - 0.2 10.9 0.5 0.89 8.8 0.3 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Nexin_C PF08628.12 ORX66434.1 - 1.4e-18 67.5 0.6 3.9e-18 66.1 0.2 2.0 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 ORX66434.1 - 6.7e-15 55.1 0.2 1.5e-14 53.9 0.2 1.6 1 0 0 1 1 1 1 PX domain RGS PF00615.19 ORX66434.1 - 1.1e-08 35.3 0.0 3.2e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Rbsn PF11464.8 ORX66434.1 - 0.00028 20.5 0.8 0.00096 18.8 0.2 2.2 2 0 0 2 2 2 1 Rabenosyn Rab binding domain DNA_pol_phi PF04931.13 ORX66434.1 - 0.14 10.2 1.2 0.15 10.1 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase phi Piwi PF02171.17 ORX66436.1 - 6.8e-75 252.1 0.0 1.1e-74 251.4 0.0 1.4 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 ORX66436.1 - 2.9e-13 49.9 0.1 1e-12 48.2 0.1 2.0 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 ORX66436.1 - 2.8e-10 40.4 0.1 2.9e-09 37.1 0.0 2.7 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoN PF16486.5 ORX66436.1 - 2.4e-08 34.7 0.0 4.5e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute zf-C2H2_jaz PF12171.8 ORX66437.1 - 0.0022 18.3 2.0 0.0027 18.0 2.0 1.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ORX66437.1 - 0.0044 17.3 0.3 0.0045 17.3 0.3 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ORX66437.1 - 0.021 15.2 2.1 0.03 14.7 2.1 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ORX66437.1 - 0.022 15.6 0.9 0.032 15.1 0.9 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger CAP PF00188.26 ORX66439.1 - 2.3e-14 54.3 0.3 4.3e-14 53.4 0.3 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family IlvB_leader PF08049.11 ORX66439.1 - 0.086 12.8 0.5 0.22 11.5 0.5 1.7 1 0 0 1 1 1 0 IlvB leader peptide CAP PF00188.26 ORX66440.1 - 1.5e-11 45.2 0.1 1.9e-11 44.9 0.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Glyco_hydro_61 PF03443.14 ORX66441.1 - 4e-53 180.4 0.0 6e-53 179.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 MAGE PF01454.19 ORX66442.1 - 0.066 12.9 0.6 0.076 12.7 0.6 1.0 1 0 0 1 1 1 0 MAGE family ABC2_membrane PF01061.24 ORX66443.1 - 4.1e-65 219.1 56.5 8e-40 136.5 17.8 3.6 3 1 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 ORX66443.1 - 1.2e-38 132.7 0.1 1.1e-18 68.1 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 ORX66443.1 - 7.9e-25 86.6 4.8 4.6e-21 74.5 0.2 3.6 4 0 0 4 4 3 2 CDR ABC transporter RsgA_GTPase PF03193.16 ORX66443.1 - 1.1e-07 31.9 0.2 0.00057 19.8 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase ABC2_membrane_3 PF12698.7 ORX66443.1 - 1.7e-07 30.7 43.7 1e-05 24.8 15.0 3.1 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 ORX66443.1 - 8.1e-06 25.9 0.2 0.011 15.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX66443.1 - 1.8e-05 24.3 1.8 0.0022 17.7 0.4 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX66443.1 - 2.9e-05 24.5 0.1 0.069 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX66443.1 - 0.00041 20.6 0.1 0.26 11.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain ABC_trans_N PF14510.6 ORX66443.1 - 0.00081 20.0 0.1 0.0019 18.8 0.1 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 ORX66443.1 - 0.0047 16.5 0.0 0.064 12.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX66443.1 - 0.0089 16.2 0.0 0.23 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX66443.1 - 0.014 16.0 0.0 1.5 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ORX66443.1 - 0.031 14.4 0.1 5.9 7.0 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 ORX66443.1 - 0.037 13.5 0.0 8.6 5.7 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ORX66443.1 - 0.073 12.3 0.0 8.7 5.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ORX66443.1 - 0.092 12.5 0.1 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ORX66443.1 - 0.12 12.6 1.2 0.7 10.1 0.4 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ORX66443.1 - 0.15 11.7 1.8 0.45 10.1 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 ORX66443.1 - 0.15 10.7 0.1 1.9 7.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 ORX66443.1 - 0.31 10.9 2.0 1.4 8.8 0.0 2.7 3 0 0 3 3 3 0 NACHT domain AAA_23 PF13476.6 ORX66443.1 - 0.72 10.3 2.3 0.78 10.2 0.1 2.2 3 0 0 3 3 1 0 AAA domain DUF2591 PF10765.9 ORX66444.1 - 0.14 12.4 0.1 0.25 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) JmjC PF02373.22 ORX66446.1 - 1.2e-40 138.5 0.1 2.3e-40 137.6 0.1 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 ORX66446.1 - 5.9e-15 55.4 12.0 2.1e-13 50.4 5.0 2.8 2 1 0 2 2 2 2 PHD-zinc-finger like domain JmjN PF02375.17 ORX66446.1 - 4.9e-12 45.6 0.1 1.2e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.6 ORX66446.1 - 7.1e-12 45.4 15.1 2.6e-11 43.6 4.3 3.2 1 1 1 2 2 2 1 PHD-like zinc-binding domain PHD PF00628.29 ORX66446.1 - 0.00038 20.3 19.9 0.00072 19.4 3.5 3.2 3 0 0 3 3 3 2 PHD-finger C1_2 PF03107.16 ORX66446.1 - 0.0089 16.3 10.0 0.053 13.8 0.1 3.6 3 0 0 3 3 3 1 C1 domain C1_1 PF00130.22 ORX66446.1 - 0.14 12.1 0.1 0.14 12.1 0.1 3.8 4 1 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_4 PF13717.6 ORX66446.1 - 5.9 6.9 9.1 0.45 10.5 1.5 2.8 2 0 0 2 2 2 0 zinc-ribbon domain PHD_2 PF13831.6 ORX66446.1 - 6.1 6.5 14.1 0.11 12.0 1.7 3.2 3 0 0 3 3 3 0 PHD-finger zf-RING-like PF08746.11 ORX66446.1 - 6.7 7.1 14.1 2.4 8.5 1.8 3.3 2 0 0 2 2 2 0 RING-like domain ECH_2 PF16113.5 ORX66447.1 - 5.3e-122 407.5 0.0 6.3e-122 407.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX66447.1 - 1e-26 93.8 0.1 2e-24 86.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF4456 PF14644.6 ORX66447.1 - 0.011 15.5 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) Pkinase PF00069.25 ORX66451.1 - 2.7e-14 53.2 0.1 3.6e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66451.1 - 3.4e-06 26.5 0.0 4.4e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase GAT PF03127.14 ORX66453.1 - 0.19 12.0 0.1 0.36 11.2 0.1 1.4 1 0 0 1 1 1 0 GAT domain GIT_CC PF16559.5 ORX66453.1 - 0.32 10.9 1.5 0.67 9.9 1.5 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Aft1_HRA PF11786.8 ORX66455.1 - 0.053 13.9 0.5 1.7 9.0 0.2 3.2 2 0 0 2 2 2 0 Aft1 HRA domain DUF2956 PF11169.8 ORX66455.1 - 0.08 13.1 3.8 0.16 12.2 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) SUIM_assoc PF16619.5 ORX66455.1 - 5.2 7.2 11.2 2.6 8.2 4.8 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DivIC PF04977.15 ORX66456.1 - 5.8 6.8 9.6 1.4e+02 2.4 8.2 3.1 3 0 0 3 3 3 0 Septum formation initiator Spt20 PF12090.8 ORX66460.1 - 0.0034 17.0 11.5 0.0034 17.0 11.5 2.2 2 0 0 2 2 2 1 Spt20 family Sin_N PF04801.13 ORX66460.1 - 0.0044 16.3 5.5 0.0087 15.3 5.5 1.4 1 0 0 1 1 1 1 Sin-like protein conserved region EPL1 PF10513.9 ORX66460.1 - 0.021 15.2 2.2 0.069 13.5 2.2 1.9 1 0 0 1 1 1 0 Enhancer of polycomb-like zf-RING_2 PF13639.6 ORX66461.1 - 3.6e-08 33.6 1.8 7.3e-08 32.6 1.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX66461.1 - 2.2e-06 27.6 0.5 9.5e-06 25.6 0.1 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX66461.1 - 3.9e-05 23.4 0.7 8.9e-05 22.3 0.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX66461.1 - 0.00018 21.3 1.3 0.00045 20.0 1.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX66461.1 - 0.00045 20.1 1.9 0.00086 19.2 1.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ORX66461.1 - 0.00052 20.2 2.9 0.0012 19.0 1.7 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain UPF0242 PF06785.11 ORX66461.1 - 0.00065 19.9 0.1 0.0011 19.1 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus FadA PF09403.10 ORX66461.1 - 0.0018 18.7 3.9 0.0036 17.8 3.9 1.5 1 0 0 1 1 1 1 Adhesion protein FadA FANCL_C PF11793.8 ORX66461.1 - 0.016 15.3 1.8 0.039 14.1 1.8 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 ORX66461.1 - 0.025 14.4 1.4 0.26 11.2 1.4 2.3 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 bZIP_1 PF00170.21 ORX66461.1 - 0.028 14.5 0.2 0.059 13.5 0.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor zf-RING_11 PF17123.5 ORX66461.1 - 0.033 13.9 2.3 0.076 12.8 2.3 1.7 1 0 0 1 1 1 0 RING-like zinc finger YscO PF07321.12 ORX66461.1 - 0.043 13.8 5.3 0.11 12.5 5.3 1.6 1 0 0 1 1 1 0 Type III secretion protein YscO HMMR_N PF15905.5 ORX66461.1 - 0.05 13.1 3.6 0.078 12.4 3.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Antistasin PF02822.14 ORX66461.1 - 0.05 14.2 0.4 0.31 11.7 0.3 2.2 2 0 0 2 2 2 0 Antistasin family zf-ANAPC11 PF12861.7 ORX66461.1 - 0.051 13.6 1.4 0.42 10.7 1.1 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ORX66461.1 - 0.054 13.4 0.5 0.054 13.4 0.5 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) KASH_CCD PF14662.6 ORX66461.1 - 0.097 12.5 4.0 0.17 11.7 4.0 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH zf-Nse PF11789.8 ORX66461.1 - 0.11 12.3 0.4 0.25 11.2 0.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF1664 PF07889.12 ORX66461.1 - 0.12 12.4 2.0 0.21 11.7 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ORX66461.1 - 0.24 10.3 6.2 0.43 9.4 6.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CLZ PF16526.5 ORX66461.1 - 0.62 10.5 2.7 0.59 10.5 0.7 2.0 2 0 0 2 2 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels zf-C3HC4_4 PF15227.6 ORX66461.1 - 0.79 9.9 5.2 0.23 11.6 1.5 2.1 2 1 0 2 2 1 0 zinc finger of C3HC4-type, RING Apt1 PF10351.9 ORX66461.1 - 1.1 8.1 11.7 0.013 14.4 2.8 1.9 2 0 0 2 2 2 0 Golgi-body localisation protein domain Prefoldin_2 PF01920.20 ORX66461.1 - 8 6.5 9.2 11 6.0 3.3 2.4 1 1 1 2 2 2 0 Prefoldin subunit NFACT-R_1 PF05670.13 ORX66462.1 - 7.3e-43 145.7 0.0 1.2e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF1682 PF07946.14 ORX66462.1 - 1.7 7.7 11.6 2.2 7.4 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Glyco_hydro_46 PF01374.18 ORX66463.1 - 2.4e-44 151.5 4.9 9e-44 149.6 4.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 TatD_DNase PF01026.21 ORX66466.1 - 6.3e-60 202.7 0.0 8.2e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ORX66466.1 - 0.063 13.0 0.1 7.6 6.2 0.0 3.0 1 1 0 3 3 3 0 Amidohydrolase Polyketide_cyc2 PF10604.9 ORX66467.1 - 9.9e-09 35.6 1.2 1.3e-08 35.2 1.2 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Trypsin PF00089.26 ORX66468.1 - 0.00072 19.4 0.1 0.00096 19.0 0.1 1.2 1 0 0 1 1 1 1 Trypsin CDC73_C PF05179.14 ORX66469.1 - 3.6e-51 172.9 0.6 5.8e-51 172.3 0.6 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 ORX66469.1 - 3.5e-18 66.0 0.6 3.2e-14 53.0 0.1 2.4 1 1 1 2 2 2 2 Paf1 complex subunit CDC73 N-terminal AAA_5 PF07728.14 ORX66470.1 - 1.8e-129 426.4 0.0 1.2e-24 86.9 0.0 8.4 8 0 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ORX66470.1 - 2.3e-40 137.0 4.9 1.5e-12 47.6 0.2 5.6 5 0 0 5 5 5 4 Midasin AAA lid domain AAA_3 PF07726.11 ORX66470.1 - 9.8e-33 112.8 0.0 7.1e-09 35.6 0.0 7.4 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ORX66470.1 - 7.7e-32 110.5 0.0 0.00022 21.7 0.0 6.9 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX66470.1 - 3.4e-27 95.9 14.8 0.00015 22.2 2.0 8.0 7 2 0 7 7 6 6 AAA ATPase domain AAA_6 PF12774.7 ORX66470.1 - 3.5e-26 92.0 0.2 0.0037 16.3 0.0 8.1 7 1 0 7 7 7 7 Hydrolytic ATP binding site of dynein motor region AAA_lid_5 PF17865.1 ORX66470.1 - 7.2e-26 90.3 4.3 1e-24 86.7 0.1 4.5 6 0 0 6 6 2 1 Midasin AAA lid domain AAA_7 PF12775.7 ORX66470.1 - 1.8e-25 89.5 8.5 8.6e-05 22.1 0.1 6.6 6 0 0 6 6 6 6 P-loop containing dynein motor region AAA_22 PF13401.6 ORX66470.1 - 1.1e-21 77.5 4.9 0.0012 19.1 0.0 7.4 6 1 0 6 6 6 4 AAA domain TsaE PF02367.17 ORX66470.1 - 2.3e-20 72.8 6.6 0.044 13.8 0.0 6.5 6 0 0 6 6 6 6 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ORX66470.1 - 3.1e-20 73.1 0.4 0.05 14.2 0.0 6.8 6 0 0 6 6 6 5 AAA domain AAA_30 PF13604.6 ORX66470.1 - 1.6e-19 70.4 0.0 0.045 13.5 0.0 7.5 6 2 0 6 6 6 4 AAA domain Dynein_heavy PF03028.15 ORX66470.1 - 2.1e-19 69.8 0.0 0.0097 16.0 0.0 6.6 6 0 0 6 6 5 4 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 ORX66470.1 - 1.2e-18 67.4 0.0 0.044 13.5 0.0 7.3 7 0 0 7 7 7 4 Sigma-54 interaction domain AAA_33 PF13671.6 ORX66470.1 - 2.7e-18 66.5 0.7 0.2 11.8 0.0 6.7 6 0 0 6 6 6 4 AAA domain AAA_14 PF13173.6 ORX66470.1 - 8.9e-18 64.6 0.0 0.0015 18.6 0.0 6.8 7 0 0 7 7 6 2 AAA domain Sigma54_activ_2 PF14532.6 ORX66470.1 - 1.1e-16 61.2 1.3 0.00059 20.0 0.0 7.0 7 0 0 7 7 6 3 Sigma-54 interaction domain NACHT PF05729.12 ORX66470.1 - 4.4e-16 59.2 6.6 0.1 12.5 0.1 6.7 6 0 0 6 6 6 5 NACHT domain ABC_tran PF00005.27 ORX66470.1 - 1.6e-15 57.8 4.0 0.041 14.4 0.0 6.5 6 0 0 6 6 6 3 ABC transporter Mg_chelatase PF01078.21 ORX66470.1 - 2.2e-13 50.0 5.9 2.5 7.4 0.0 9.7 9 1 0 10 10 10 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 ORX66470.1 - 3.5e-13 49.9 3.7 0.44 10.4 0.1 6.5 6 0 0 6 6 6 2 Rad17 P-loop domain RNA_helicase PF00910.22 ORX66470.1 - 1.4e-12 47.9 2.3 0.61 10.5 0.0 6.7 6 0 0 6 6 6 1 RNA helicase AAA_29 PF13555.6 ORX66470.1 - 1.6e-12 46.9 0.4 0.41 10.4 0.1 6.6 6 0 0 6 6 6 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX66470.1 - 3.4e-11 43.3 2.1 0.67 9.8 0.0 6.8 7 0 0 7 7 6 2 RsgA GTPase cobW PF02492.19 ORX66470.1 - 6.3e-11 42.2 1.9 2.2 7.8 0.0 6.4 6 0 0 6 6 6 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 ORX66470.1 - 1.1e-10 41.0 5.5 0.82 8.7 0.0 6.5 6 0 0 6 6 6 3 Type II/IV secretion system protein RuvB_N PF05496.12 ORX66470.1 - 2.9e-10 40.1 3.3 1.4 8.6 0.1 7.7 7 1 0 7 7 7 1 Holliday junction DNA helicase RuvB P-loop domain dNK PF01712.19 ORX66470.1 - 6e-10 39.3 4.9 0.64 9.8 0.1 6.3 6 0 0 6 6 6 1 Deoxynucleoside kinase IstB_IS21 PF01695.17 ORX66470.1 - 6.1e-10 39.1 2.3 2.1 8.0 0.0 6.6 6 1 1 7 7 6 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 ORX66470.1 - 1.2e-09 37.8 1.4 1.7 7.9 0.0 6.5 6 0 0 6 6 6 1 Zeta toxin PduV-EutP PF10662.9 ORX66470.1 - 1.2e-09 38.1 2.2 0.017 14.9 0.0 6.2 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 ORX66470.1 - 1.5e-09 37.7 7.0 0.72 9.4 0.0 6.1 6 0 0 6 6 6 3 AAA domain DUF815 PF05673.13 ORX66470.1 - 1.8e-09 37.2 1.7 1.7 7.7 0.0 6.2 6 0 0 6 6 6 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 ORX66470.1 - 4.3e-09 36.8 13.0 0.9 9.8 0.1 7.0 7 0 0 7 7 6 1 AAA domain AAA_23 PF13476.6 ORX66470.1 - 7e-09 36.5 0.0 2.6 8.5 0.0 5.6 6 0 0 6 6 5 0 AAA domain AAA_19 PF13245.6 ORX66470.1 - 3.6e-08 33.8 6.3 1.5 9.2 0.1 6.5 6 0 0 6 6 6 2 AAA domain Viral_helicase1 PF01443.18 ORX66470.1 - 4.9e-08 33.0 0.4 0.54 10.0 0.0 6.0 6 0 0 6 6 5 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 ORX66470.1 - 2.2e-07 30.8 2.5 4.7 6.9 0.0 6.6 6 1 1 8 8 7 0 AAA domain AAA_11 PF13086.6 ORX66470.1 - 3.8e-07 30.2 0.3 17 5.1 0.0 6.6 7 0 0 7 7 7 0 AAA domain ATPase_2 PF01637.18 ORX66470.1 - 1e-06 28.9 0.0 5.4 6.8 0.0 5.9 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea SRP54 PF00448.22 ORX66470.1 - 2.8e-06 27.1 8.8 1.4 8.5 0.0 5.8 6 0 0 6 6 5 1 SRP54-type protein, GTPase domain Roc PF08477.13 ORX66470.1 - 3.3e-06 27.3 5.5 5.2 7.3 0.0 6.3 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase AAA_8 PF12780.7 ORX66470.1 - 4.1e-06 26.3 1.5 3.6 6.8 0.0 5.9 7 0 0 7 7 5 0 P-loop containing dynein motor region D4 TniB PF05621.11 ORX66470.1 - 7.8e-06 25.4 0.2 9.9 5.5 0.0 6.0 6 0 0 6 6 6 0 Bacterial TniB protein Cytidylate_kin PF02224.18 ORX66470.1 - 1.4e-05 24.9 1.1 3.5 7.3 0.0 4.9 5 0 0 5 5 4 0 Cytidylate kinase CbiA PF01656.23 ORX66470.1 - 1.6e-05 25.0 1.8 0.13 12.3 0.0 4.2 4 0 0 4 4 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 ORX66470.1 - 2.2e-05 24.4 9.1 5.4 6.7 0.1 6.0 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 ORX66470.1 - 2.8e-05 24.1 9.1 1.4 8.8 0.0 6.1 6 0 0 6 6 6 1 NTPase TIP49 PF06068.13 ORX66470.1 - 3.5e-05 23.2 2.6 6.4 5.9 0.0 5.4 6 0 0 6 6 6 0 TIP49 P-loop domain MMR_HSR1 PF01926.23 ORX66470.1 - 0.00012 22.1 2.1 31 4.7 0.0 5.4 5 0 0 5 5 5 0 50S ribosome-binding GTPase SRPRB PF09439.10 ORX66470.1 - 0.00014 21.4 2.7 11 5.4 0.0 5.4 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit ATPase PF06745.13 ORX66470.1 - 0.00028 20.3 0.2 11 5.3 0.0 4.9 6 0 0 6 6 5 0 KaiC ATP-synt_ab PF00006.25 ORX66470.1 - 0.00095 18.9 0.0 4.8 6.8 0.0 4.8 6 0 0 6 6 5 0 ATP synthase alpha/beta family, nucleotide-binding domain IPT PF01745.16 ORX66470.1 - 0.0012 18.3 1.3 2.2 7.6 0.0 5.2 5 0 0 5 5 5 1 Isopentenyl transferase NB-ARC PF00931.22 ORX66470.1 - 0.0012 18.1 3.5 9.8 5.3 0.0 4.8 5 0 0 5 5 5 0 NB-ARC domain DEAD PF00270.29 ORX66470.1 - 0.0019 18.0 5.8 22 4.8 0.0 6.0 6 1 0 6 6 5 0 DEAD/DEAH box helicase AAA_17 PF13207.6 ORX66470.1 - 0.0098 16.3 6.3 9.6 6.6 0.1 5.4 6 0 0 6 6 5 0 AAA domain PhoH PF02562.16 ORX66470.1 - 0.0099 15.3 5.1 0.98 8.8 0.0 4.6 6 0 0 6 6 4 1 PhoH-like protein AAA_9 PF12781.7 ORX66470.1 - 0.01 15.0 0.0 1.8 7.6 0.0 4.1 5 0 0 5 5 5 0 ATP-binding dynein motor region DnaB_C PF03796.15 ORX66470.1 - 0.014 14.7 0.8 0.64 9.3 0.0 4.0 6 0 0 6 6 4 0 DnaB-like helicase C terminal domain CPT PF07931.12 ORX66470.1 - 0.024 14.5 6.3 21 4.9 0.0 6.7 8 0 0 8 8 6 0 Chloramphenicol phosphotransferase-like protein tRNA_lig_kinase PF08303.11 ORX66470.1 - 0.06 13.4 0.4 4.8 7.2 0.1 3.8 4 0 0 4 4 4 0 tRNA ligase kinase domain SKI PF01202.22 ORX66470.1 - 0.061 13.4 8.6 24 5.0 0.1 5.9 6 0 0 6 6 6 0 Shikimate kinase DAP3 PF10236.9 ORX66470.1 - 0.063 12.4 4.8 20 4.3 0.0 4.6 5 0 0 5 5 5 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.9 ORX66470.1 - 0.085 12.1 0.6 2.5 7.3 0.0 3.3 4 0 0 4 4 3 0 Uncharacterized conserved protein (DUF2075) Septin PF00735.18 ORX66470.1 - 0.12 11.6 1.4 42 3.3 0.0 4.2 5 0 0 5 5 4 0 Septin DUF853 PF05872.12 ORX66470.1 - 0.12 10.9 0.9 6.6 5.2 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) ResIII PF04851.15 ORX66470.1 - 0.18 11.8 7.3 11 6.0 0.0 5.0 7 0 0 7 7 4 0 Type III restriction enzyme, res subunit AAA_PrkA PF08298.11 ORX66470.1 - 0.18 10.7 0.2 22 3.8 0.0 3.3 4 0 0 4 4 3 0 PrkA AAA domain CoaE PF01121.20 ORX66470.1 - 0.24 11.1 1.9 13 5.4 0.0 4.0 4 0 0 4 4 3 0 Dephospho-CoA kinase TrwB_AAD_bind PF10412.9 ORX66470.1 - 0.88 8.4 6.7 35 3.2 0.1 5.2 7 0 0 7 7 6 0 Type IV secretion-system coupling protein DNA-binding domain Thymidylate_kin PF02223.17 ORX66470.1 - 1.4 8.5 4.0 63 3.2 0.0 4.5 6 0 0 6 6 4 0 Thymidylate kinase CLP1_P PF16575.5 ORX66470.1 - 2.8 7.7 7.7 11 5.8 0.1 4.3 5 0 0 5 5 4 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VWA_2 PF13519.6 ORX66473.1 - 2.7e-05 24.8 1.3 5.1e-05 23.9 0.1 2.1 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 ORX66473.1 - 9.3e-05 22.7 0.1 0.00015 22.1 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ORX66473.1 - 0.0025 17.3 1.0 0.005 16.3 1.0 1.6 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 ORX66473.1 - 0.015 15.5 0.1 0.027 14.6 0.1 1.4 1 0 0 1 1 1 0 vWA found in TerF C terminus PEX-1N PF09262.11 ORX66473.1 - 0.12 12.8 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal Cys_Met_Meta_PP PF01053.20 ORX66474.1 - 9.8e-126 419.3 0.0 1.1e-125 419.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX66474.1 - 2.7e-11 43.4 0.0 1.2e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ORX66474.1 - 4.9e-10 38.9 0.0 7.7e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ORX66474.1 - 1.1e-09 38.0 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX66474.1 - 3.5e-06 26.5 0.0 7.1e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 ORX66474.1 - 0.00015 22.0 0.0 0.00047 20.4 0.0 1.8 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain GDC-P PF02347.16 ORX66474.1 - 0.009 14.9 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein SHMT PF00464.19 ORX66474.1 - 0.021 13.5 0.1 0.077 11.6 0.1 1.9 1 1 0 1 1 1 0 Serine hydroxymethyltransferase OmdA PF13376.6 ORX66474.1 - 0.18 11.9 0.3 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated DUF2304 PF10066.9 ORX66475.1 - 0.082 13.1 2.7 0.47 10.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Phage_lysozyme PF00959.19 ORX66477.1 - 4.1e-14 53.0 0.0 6e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX66477.1 - 0.00034 20.8 0.1 0.001 19.3 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain CHAP PF05257.16 ORX66478.1 - 6.9e-14 52.2 4.2 1.6e-13 51.0 4.2 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX66478.1 - 9.2e-08 32.3 0.2 2.3e-07 31.0 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain PGM_PMM_I PF02878.16 ORX66479.1 - 3.4e-35 120.8 0.0 6.8e-35 119.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ORX66479.1 - 1.9e-24 86.2 0.9 4e-24 85.2 0.3 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ORX66479.1 - 9.1e-19 67.7 0.2 1.8e-18 66.8 0.2 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 ORX66479.1 - 1.1e-06 28.6 0.0 7.3e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF4148 PF13663.6 ORX66479.1 - 0.011 15.9 1.5 7.6 6.8 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) DUF1242 PF06842.12 ORX66480.1 - 2.1e-15 56.2 0.5 2.9e-15 55.8 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) LST1 PF05083.13 ORX66480.1 - 0.48 10.7 2.8 1.7 9.0 2.2 1.9 1 1 1 2 2 2 0 LST-1 protein Glyco_hydro_46 PF01374.18 ORX66482.1 - 2.4e-44 151.5 4.9 9e-44 149.6 4.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 ThiF PF00899.21 ORX66483.1 - 2.4e-39 135.2 0.0 4.9e-29 101.4 0.0 2.1 1 1 1 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ORX66483.1 - 6.1e-12 46.0 0.1 8.6e-06 25.9 0.0 2.5 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 ORX66483.1 - 4.5e-07 30.4 0.0 9.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Pyr_redox PF00070.27 ORX66483.1 - 0.0036 17.8 0.4 0.87 10.2 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Sas10 PF09368.10 ORX66484.1 - 7.9e-28 96.8 9.6 7.9e-28 96.8 9.6 3.4 4 1 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 ORX66484.1 - 4.2e-10 40.1 3.9 7.4e-09 36.1 0.0 4.1 3 1 0 3 3 3 1 Sas10/Utp3/C1D family CAP PF00188.26 ORX66484.1 - 0.086 13.7 1.3 0.23 12.3 1.3 1.8 1 0 0 1 1 1 0 Cysteine-rich secretory protein family COPIIcoated_ERV PF07970.12 ORX66485.1 - 1.3e-44 152.7 12.4 3.2e-28 99.1 1.5 3.1 1 1 1 2 2 2 2 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ORX66485.1 - 8e-29 99.8 0.1 3e-28 98.0 0.0 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ATP12 PF07542.11 ORX66486.1 - 4.5e-30 104.4 0.0 8.4e-30 103.5 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Glyco_transf_25 PF01755.17 ORX66487.1 - 2.2e-13 50.5 0.0 4.1e-11 43.1 0.0 2.1 1 1 1 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF3343 PF11823.8 ORX66487.1 - 0.17 11.4 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) PQ-loop PF04193.14 ORX66490.1 - 0.07 12.9 0.0 0.07 12.9 0.0 2.4 3 0 0 3 3 3 0 PQ loop repeat zf-C2H2 PF00096.26 ORX66492.1 - 4.3e-23 80.4 24.8 1.9e-06 28.0 2.3 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX66492.1 - 6.8e-20 70.5 22.0 2.8e-08 33.8 0.1 4.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX66492.1 - 1.4e-13 50.4 24.5 0.00053 20.6 1.7 4.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 ORX66492.1 - 3.1e-07 30.6 7.3 0.55 10.7 0.5 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX66492.1 - 1.3e-06 28.6 9.4 0.15 12.4 0.1 4.3 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX66492.1 - 2.5e-06 28.0 10.6 0.41 11.3 0.2 4.0 1 1 3 4 4 4 3 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 ORX66492.1 - 0.0027 17.5 10.3 0.013 15.4 0.4 3.8 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 ORX66492.1 - 0.0058 16.9 7.4 2.1 8.7 0.0 2.7 1 1 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 ORX66492.1 - 0.15 12.2 4.9 3.1 7.9 0.1 3.4 1 1 3 4 4 4 0 Aberrant zinc-finger zf-C2H2_11 PF16622.5 ORX66492.1 - 0.33 10.7 16.5 0.16 11.7 1.6 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX66492.1 - 1.8 8.6 12.8 3.6 7.7 0.1 3.9 4 1 0 4 4 4 0 C2H2-type zinc finger Presenilin PF01080.17 ORX66493.1 - 3.5 6.3 5.4 4.2 6.0 5.4 1.0 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ORX66493.1 - 5.6 5.0 4.6 6.2 4.8 4.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Septin PF00735.18 ORX66494.1 - 1.6e-106 355.7 0.1 2e-106 355.4 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX66494.1 - 5.6e-09 36.1 0.0 1.1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX66494.1 - 4.2e-08 33.3 0.9 1.2e-07 31.7 0.2 2.0 3 0 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 ORX66494.1 - 1.7e-07 30.8 0.2 3.1e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 AIG1 family AAA_16 PF13191.6 ORX66494.1 - 2.1e-05 25.0 0.1 0.00015 22.2 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain Roc PF08477.13 ORX66494.1 - 4.3e-05 23.7 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ORX66494.1 - 0.00043 19.6 0.1 0.00069 18.9 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain Ras PF00071.22 ORX66494.1 - 0.00047 19.8 0.1 0.0011 18.5 0.1 1.6 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 ORX66494.1 - 0.0005 19.7 0.8 0.0046 16.5 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF815 PF05673.13 ORX66494.1 - 0.00091 18.5 0.1 0.002 17.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Dynamin_N PF00350.23 ORX66494.1 - 0.0016 18.6 3.8 0.17 12.0 0.6 2.7 2 1 1 3 3 2 2 Dynamin family ABC_tran PF00005.27 ORX66494.1 - 0.0021 18.6 0.2 0.005 17.4 0.2 1.7 1 1 0 1 1 1 1 ABC transporter RuvB_N PF05496.12 ORX66494.1 - 0.0067 16.2 0.1 0.037 13.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 ORX66494.1 - 0.0083 15.8 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TniB PF05621.11 ORX66494.1 - 0.0087 15.5 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 ORX66494.1 - 0.013 15.8 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ORX66494.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 ORX66494.1 - 0.014 15.3 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 ORX66494.1 - 0.016 15.1 0.4 0.8 9.6 0.0 2.6 1 1 1 2 2 2 0 NTPase AAA_7 PF12775.7 ORX66494.1 - 0.029 13.9 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 ORX66494.1 - 0.041 13.0 0.1 0.056 12.6 0.1 1.3 1 1 0 1 1 1 0 G-protein alpha subunit Sigma54_activat PF00158.26 ORX66494.1 - 0.044 13.5 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ORX66494.1 - 0.05 14.0 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.18 ORX66494.1 - 0.077 12.3 0.2 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ORX66494.1 - 0.084 12.6 0.1 0.35 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 ORX66494.1 - 0.11 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Gtr1_RagA PF04670.12 ORX66494.1 - 0.13 11.6 0.3 0.44 9.9 0.0 1.9 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_28 PF13521.6 ORX66494.1 - 0.16 12.2 3.9 0.26 11.5 0.2 2.9 2 1 0 2 2 2 0 AAA domain zf-CHY PF05495.12 ORX66495.1 - 1.6e-14 54.1 13.9 4e-14 52.9 13.9 1.6 1 1 0 1 1 1 1 CHY zinc finger DUF3909 PF13077.6 ORX66495.1 - 0.0046 17.1 0.1 0.0078 16.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3909) Zn-ribbon_8 PF09723.10 ORX66495.1 - 0.0094 16.0 3.0 0.0094 16.0 3.0 2.6 2 1 0 2 2 2 1 Zinc ribbon domain Cys_rich_KTR PF14205.6 ORX66495.1 - 0.012 15.3 5.7 2.9 7.8 0.0 2.7 2 1 0 2 2 2 0 Cysteine-rich KTR Zn_Tnp_IS1595 PF12760.7 ORX66495.1 - 0.026 14.5 11.1 0.78 9.8 6.3 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF4379 PF14311.6 ORX66495.1 - 0.03 14.7 0.7 0.03 14.7 0.7 2.3 1 1 0 2 2 2 0 Probable Zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 ORX66495.1 - 0.036 14.0 5.8 0.066 13.2 1.0 2.8 2 1 0 2 2 2 0 PhnA Zinc-Ribbon HypA PF01155.19 ORX66495.1 - 0.04 13.9 1.7 0.04 13.9 1.7 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_6 PF13912.6 ORX66495.1 - 0.044 13.8 5.0 0.52 10.4 1.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 ORX66495.1 - 0.1 12.6 0.1 0.1 12.6 0.1 2.6 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Elf1 PF05129.13 ORX66495.1 - 0.12 12.5 10.9 1.6 8.9 11.4 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 ORX66495.1 - 0.16 11.9 13.9 1.5 8.8 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 ORX66495.1 - 0.28 10.7 8.5 1.8 8.1 3.4 2.7 1 1 1 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 ORX66495.1 - 0.62 9.9 7.8 3.5 7.5 0.2 3.3 3 0 0 3 3 3 0 zinc-ribbon domain C1_4 PF07975.12 ORX66495.1 - 0.79 10.0 13.1 13 6.1 0.3 3.1 1 1 2 3 3 3 0 TFIIH C1-like domain zinc_ribbon_9 PF14369.6 ORX66495.1 - 0.9 9.8 10.8 0.77 10.1 1.6 3.3 2 1 1 3 3 3 0 zinc-ribbon Zn_Tnp_IS91 PF14319.6 ORX66495.1 - 1.1 9.3 12.9 1.3 9.1 5.3 2.3 1 1 1 2 2 2 0 Transposase zinc-binding domain DUF3797 PF12677.7 ORX66495.1 - 1.5 8.7 9.2 0.94 9.4 0.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) DpnI PF06044.12 ORX66495.1 - 2.8 7.6 7.2 9.3 5.8 2.7 2.1 1 1 1 2 2 2 0 Dam-replacing family zinc_ribbon_10 PF10058.9 ORX66495.1 - 3.4 7.5 9.1 1 9.1 2.8 2.4 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein ISK_Channel PF02060.15 ORX66497.1 - 0.16 11.7 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 Slow voltage-gated potassium channel Malic_M PF03949.15 ORX66499.1 - 2.3e-78 263.0 0.0 3.1e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX66499.1 - 4.7e-58 196.0 0.0 8.1e-58 195.2 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain LETM1 PF07766.13 ORX66501.1 - 8.1e-29 100.8 0.1 3e-13 49.8 0.0 2.0 1 1 1 2 2 2 2 LETM1-like protein FBPase PF00316.20 ORX66503.1 - 3e-67 225.8 0.0 3.9e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Ribonuclease_P PF00825.18 ORX66505.1 - 7.7e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease P Glyco_transf_5 PF08323.11 ORX66507.1 - 0.071 12.8 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Starch synthase catalytic domain Sec63 PF02889.16 ORX66508.1 - 1.4e-10 40.8 0.0 3.1e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 ORX66508.1 - 0.012 15.9 0.0 0.067 13.5 0.0 2.2 1 1 0 1 1 1 0 Helicase conserved C-terminal domain DEAD PF00270.29 ORX66509.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase Peptidase_M24 PF00557.24 ORX66513.1 - 1.7e-13 50.8 0.0 2.4e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Toxin_R_bind_C PF07951.12 ORX66513.1 - 0.095 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding WD40 PF00400.32 ORX66514.1 - 9.1e-14 51.6 10.6 0.005 17.7 0.2 6.6 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66514.1 - 4.6e-07 30.1 0.1 0.72 10.2 0.0 4.4 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX66514.1 - 0.0011 18.4 0.1 0.0047 16.3 0.2 1.9 1 1 1 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ORX66514.1 - 0.015 13.8 0.6 0.38 9.2 0.2 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ORX66514.1 - 0.041 12.8 0.1 5.8 5.8 0.0 3.1 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PHTB1_N PF14727.6 ORX66514.1 - 0.056 12.8 0.2 3.3 6.9 0.0 2.7 1 1 1 2 2 2 0 PTHB1 N-terminus Hist_deacetyl PF00850.19 ORX66515.1 - 1.3e-80 271.2 0.0 1.8e-80 270.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain RNA_pol_Rpb2_6 PF00562.28 ORX66516.1 - 2.5e-125 418.6 0.1 3.9e-125 418.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ORX66516.1 - 6.8e-65 218.4 0.0 1.1e-64 217.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 ORX66516.1 - 3.6e-45 153.9 0.2 9.1e-45 152.6 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ORX66516.1 - 1.2e-34 118.5 0.1 4.2e-34 116.8 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 ORX66516.1 - 8.7e-26 89.9 0.1 2.1e-25 88.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 ORX66516.1 - 1e-21 76.9 0.3 3e-21 75.5 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ORX66516.1 - 1.2e-21 77.0 0.3 1.2e-21 77.0 0.3 2.3 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_45 PF10385.9 ORX66516.1 - 0.11 12.8 0.0 1.2 9.4 0.0 2.6 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain DUF1690 PF07956.11 ORX66517.1 - 2.8e-14 53.7 1.4 5.7e-14 52.7 1.4 1.5 1 1 0 1 1 1 1 Protein of Unknown function (DUF1690) Pkinase_fungal PF17667.1 ORX66518.1 - 6.3e-30 104.3 0.2 2.3e-19 69.5 0.0 2.4 1 1 1 2 2 2 2 Fungal protein kinase Pkinase_fungal PF17667.1 ORX66520.1 - 9.5e-53 179.4 13.3 2.1e-28 99.3 0.0 3.8 2 2 0 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX66520.1 - 8e-08 32.0 0.0 1.3e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 ORX66520.1 - 0.024 14.0 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX66520.1 - 0.046 13.6 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ORX66520.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Arg_repressor PF01316.21 ORX66521.1 - 0.019 14.7 0.4 0.047 13.4 0.0 1.8 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain RRM_1 PF00076.22 ORX66522.1 - 8.5e-16 57.5 0.0 1.2e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX66522.1 - 6.5e-09 36.2 13.0 6.5e-09 36.2 13.0 1.7 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 OrsD PF12013.8 ORX66523.1 - 9.7e-06 26.0 0.5 3.2e-05 24.3 0.5 1.9 1 1 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2 PF00096.26 ORX66523.1 - 0.0064 16.9 4.7 0.72 10.4 0.6 3.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type TniQ PF06527.11 ORX66523.1 - 0.024 15.3 0.3 0.13 13.0 0.2 2.3 2 0 0 2 2 2 0 TniQ zf_C2H2_ZHX PF18387.1 ORX66523.1 - 0.12 12.1 0.1 0.32 10.7 0.1 1.8 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain TackOD1 PF18551.1 ORX66523.1 - 0.59 9.8 5.6 15 5.2 1.3 3.2 3 0 0 3 3 3 0 Thaumarchaeal output domain 1 Med7 PF05983.11 ORX66524.1 - 9.5e-50 169.3 1.8 4.4e-49 167.2 1.8 1.9 1 1 0 1 1 1 1 MED7 protein Macoilin PF09726.9 ORX66524.1 - 0.056 12.0 2.2 0.081 11.5 2.2 1.2 1 0 0 1 1 1 0 Macoilin family TetR_C_6 PF13977.6 ORX66524.1 - 0.08 13.2 1.1 0.17 12.1 1.1 1.5 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal GCS2 PF04107.13 ORX66524.1 - 0.2 11.0 1.4 0.49 9.7 1.4 1.6 1 1 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) Csm1 PF12539.8 ORX66525.1 - 4.3e-09 36.9 0.2 1.1e-08 35.6 0.1 1.7 2 0 0 2 2 2 1 Chromosome segregation protein Csm1/Pcs1 DUF5094 PF17015.5 ORX66525.1 - 0.0015 18.7 0.8 0.0015 18.7 0.8 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF5094) End3 PF12761.7 ORX66525.1 - 0.0062 16.7 9.0 0.01 16.0 9.0 1.4 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 NHR2 PF08788.11 ORX66525.1 - 0.047 13.5 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 NHR2 domain like Cnn_1N PF07989.11 ORX66525.1 - 0.052 13.7 10.7 0.031 14.4 8.5 1.8 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 ORX66525.1 - 0.44 10.6 6.3 0.75 9.8 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) NYD-SP28_assoc PF14775.6 ORX66525.1 - 0.75 9.9 3.3 21 5.3 0.1 2.5 2 0 0 2 2 2 0 Sperm tail C-terminal domain CPSF73-100_C PF11718.8 ORX66526.1 - 1.4e-41 142.4 2.7 2.6e-41 141.5 2.7 1.5 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 ORX66526.1 - 2.1e-30 105.3 0.0 4.4e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ORX66526.1 - 4.9e-19 68.5 1.0 4.9e-18 65.3 0.0 2.7 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX66526.1 - 3.3e-18 66.4 0.8 6.8e-18 65.4 0.8 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ORX66526.1 - 7.1e-17 61.1 0.1 1.4e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ORX66526.1 - 9e-08 31.9 1.2 2e-07 30.7 0.5 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX66526.1 - 1e-06 28.7 0.1 4.3e-06 26.7 0.1 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ORX66526.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family MARVEL PF01284.23 ORX66527.1 - 0.048 13.7 8.7 0.11 12.6 8.7 1.6 1 1 0 1 1 1 0 Membrane-associating domain MIG-14_Wnt-bd PF06664.12 ORX66527.1 - 0.29 10.3 5.8 0.24 10.6 1.5 2.0 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion DUF4131 PF13567.6 ORX66527.1 - 7.1 6.3 11.3 0.33 10.6 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) FtsX PF02687.21 ORX66529.1 - 0.62 10.6 8.3 1.5 9.3 1.2 2.8 2 2 0 2 2 2 0 FtsX-like permease family MARVEL PF01284.23 ORX66529.1 - 0.81 9.7 12.6 0.39 10.8 5.1 2.6 1 1 1 2 2 2 0 Membrane-associating domain STE2 PF02116.15 ORX66529.1 - 0.91 8.8 5.4 0.89 8.8 1.1 2.5 3 0 0 3 3 3 0 Fungal pheromone mating factor STE2 GPCR DUF2207 PF09972.9 ORX66531.1 - 0.16 10.7 0.0 0.16 10.7 0.0 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF1772 PF08592.11 ORX66531.1 - 0.17 12.2 4.4 1.1 9.5 4.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Tetraspanin PF00335.20 ORX66531.1 - 2.2 7.9 8.4 14 5.3 0.0 3.0 2 1 1 3 3 3 0 Tetraspanin family RCR PF12273.8 ORX66531.1 - 8.2 7.1 5.6 51 4.5 0.5 3.0 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red DUF5408 PF17402.2 ORX66533.1 - 0.16 11.9 0.3 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5408) Cytokin_check_N PF10407.9 ORX66535.1 - 0.0051 16.7 0.1 0.11 12.5 0.0 2.7 2 0 0 2 2 2 1 Cdc14 phosphatase binding protein N-terminus LRR_4 PF12799.7 ORX66535.1 - 1.8 9.1 8.0 41 4.8 0.5 4.5 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) WD40 PF00400.32 ORX66537.1 - 6.5e-33 112.2 26.1 2e-06 28.4 0.6 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ORX66537.1 - 5.4e-10 39.0 3.5 1.1e-09 38.1 3.5 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ORX66537.1 - 1.2e-09 38.3 1.0 0.031 14.6 0.0 4.5 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX66537.1 - 1.1e-06 27.6 11.5 0.066 11.9 0.1 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ORX66537.1 - 6.2e-06 25.4 0.2 0.0092 14.9 0.0 3.6 2 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ORX66537.1 - 7.5e-05 22.2 0.2 1.6 8.0 0.0 3.1 1 1 1 3 3 3 2 WD40-like domain F-box PF00646.33 ORX66537.1 - 0.00045 20.0 2.6 0.0013 18.6 2.6 1.8 1 0 0 1 1 1 1 F-box domain Hira PF07569.11 ORX66537.1 - 0.016 15.0 0.5 0.37 10.5 0.2 3.0 2 1 1 3 3 3 0 TUP1-like enhancer of split Mcl1_mid PF12341.8 ORX66537.1 - 0.041 13.2 0.3 0.84 8.9 0.1 2.2 1 1 1 2 2 2 0 Minichromosome loss protein, Mcl1, middle region Ge1_WD40 PF16529.5 ORX66537.1 - 0.044 12.7 0.7 0.85 8.5 0.0 2.9 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ORX66537.1 - 0.066 13.7 0.4 1.4 9.5 0.1 3.2 3 0 0 3 3 3 0 PQQ-like domain Toxin_ToxA PF11584.8 ORX66537.1 - 0.071 13.1 0.7 0.26 11.3 0.2 2.2 1 1 0 2 2 2 0 Proteinaceous host-selective toxin ToxA Peptidase_C3G PF12381.8 ORX66537.1 - 0.078 12.4 1.4 0.91 8.9 0.1 3.0 3 1 1 4 4 4 0 Tungro spherical virus-type peptidase SEEK1 PF15357.6 ORX66538.1 - 0.01 16.0 1.1 0.011 15.8 1.1 1.0 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 WD40 PF00400.32 ORX66539.1 - 1.8e-32 110.8 6.6 2.9e-06 27.9 0.2 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66539.1 - 1.7e-15 57.1 0.0 0.00056 20.2 0.0 5.9 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX66539.1 - 6.9e-06 25.2 0.1 0.24 10.3 0.0 3.3 2 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein CSTF1_dimer PF16699.5 ORX66539.1 - 0.0011 18.6 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain PD40 PF07676.12 ORX66539.1 - 0.038 13.9 0.0 0.59 10.1 0.0 2.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ORX66539.1 - 0.11 11.1 0.1 0.65 8.6 0.0 2.1 2 1 0 2 2 2 0 Nucleoporin Nup120/160 GST_C_5 PF16865.5 ORX66540.1 - 0.031 14.9 0.0 0.043 14.4 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX66540.1 - 0.094 12.8 1.1 0.11 12.5 1.1 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.26 ORX66541.1 - 1.8e-23 81.6 28.1 2.7e-06 27.5 2.5 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX66541.1 - 5.2e-22 77.2 20.8 9.8e-08 32.1 0.1 4.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX66541.1 - 9.6e-16 57.1 26.1 0.00017 22.2 2.0 4.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 ORX66541.1 - 3.9e-09 36.6 11.5 0.011 16.1 0.7 4.2 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX66541.1 - 1e-08 35.3 13.4 0.0017 18.6 0.1 4.2 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX66541.1 - 2.2e-07 31.4 9.3 0.075 13.7 0.2 4.0 1 1 3 4 4 4 3 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 ORX66541.1 - 6.7e-07 28.9 13.3 0.033 13.9 0.7 4.5 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 ORX66541.1 - 0.00011 22.0 8.4 0.022 14.6 0.3 3.7 3 0 0 3 3 3 1 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 ORX66541.1 - 0.00073 19.5 14.1 0.025 14.6 0.3 3.8 4 1 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX66541.1 - 0.0052 16.5 14.7 0.16 11.7 1.4 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 ORX66541.1 - 0.011 16.0 7.3 0.041 14.2 2.5 2.4 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 ORX66541.1 - 0.028 14.5 2.8 2.6 8.1 0.1 2.9 1 1 1 3 3 3 0 Aberrant zinc-finger BolA PF01722.18 ORX66541.1 - 0.096 13.0 0.7 0.096 13.0 0.7 2.6 3 0 0 3 3 3 0 BolA-like protein zf-TRAF PF02176.18 ORX66541.1 - 0.2 12.3 10.4 0.27 11.9 2.1 2.8 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_2 PF12756.7 ORX66541.1 - 0.23 11.8 7.5 5 7.5 2.2 2.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Cys_Met_Meta_PP PF01053.20 ORX66543.1 - 2e-91 306.4 0.0 4.2e-77 259.3 0.0 2.4 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ORX66543.1 - 2e-07 30.3 0.0 7.6e-07 28.4 0.0 1.8 2 1 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ORX66543.1 - 2.9e-07 30.0 0.0 6.6e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Asparaginase_C PF17763.1 ORX66543.1 - 0.0051 17.0 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain DegT_DnrJ_EryC1 PF01041.17 ORX66543.1 - 0.0056 16.0 0.1 0.01 15.2 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 ORX66543.1 - 0.013 14.1 0.0 0.021 13.3 0.0 1.3 1 0 0 1 1 1 0 Methionine gamma-lyase SepSecS PF05889.13 ORX66543.1 - 0.014 14.1 0.0 0.018 13.7 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 ORX66543.1 - 0.018 14.4 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Pyridoxal_deC PF00282.19 ORX66543.1 - 0.21 10.3 0.0 0.29 9.8 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain zf-C2H2 PF00096.26 ORX66544.1 - 3.8e-05 23.9 0.1 6.4e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type ARS2 PF04959.13 ORX66544.1 - 0.0078 16.6 0.1 0.011 16.1 0.1 1.3 1 1 0 1 1 1 1 Arsenite-resistance protein 2 zf-C2H2_4 PF13894.6 ORX66544.1 - 0.022 15.6 0.1 0.037 14.9 0.1 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4604 PF15377.6 ORX66544.1 - 0.19 12.1 5.5 0.26 11.7 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SET PF00856.28 ORX66545.1 - 8.4e-06 26.3 0.0 9.3e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 SET domain DUF5427 PF10310.9 ORX66546.1 - 6.7 5.6 11.5 2.9 6.8 6.4 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5427) Transferase PF02458.15 ORX66548.1 - 0.00092 18.0 0.0 0.14 10.8 0.0 2.1 2 0 0 2 2 2 2 Transferase family Transferase PF02458.15 ORX66549.1 - 0.0062 15.2 0.2 0.29 9.7 0.0 2.3 2 1 0 2 2 2 2 Transferase family Abhydrolase_3 PF07859.13 ORX66550.1 - 9e-31 107.4 0.1 1.2e-30 106.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX66550.1 - 4.6e-07 29.0 0.0 6.2e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Thioesterase PF00975.20 ORX66550.1 - 0.00053 20.2 0.0 0.00093 19.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 ORX66550.1 - 0.012 16.2 1.1 0.024 15.3 1.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family COesterase PF00135.28 ORX66550.1 - 0.079 11.8 0.0 0.32 9.8 0.0 1.7 2 0 0 2 2 2 0 Carboxylesterase family Hydrolase_4 PF12146.8 ORX66550.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RICTOR_V PF14668.6 ORX66552.1 - 0.032 14.4 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 Arm PF00514.23 ORX66553.1 - 5.2e-05 23.1 0.5 0.00046 20.1 1.0 2.5 2 1 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX66553.1 - 0.0088 16.5 2.5 0.34 11.5 1.4 3.3 1 1 1 2 2 2 1 HEAT-like repeat DNA_ligase_A_N PF04675.14 ORX66553.1 - 0.085 13.2 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 DNA ligase N terminus HEAT PF02985.22 ORX66553.1 - 0.54 10.7 4.7 1.4 9.4 0.3 3.7 3 1 1 4 4 4 0 HEAT repeat SUI1 PF01253.22 ORX66554.1 - 2e-23 82.7 0.2 4.5e-23 81.6 0.2 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Acylphosphatase PF00708.18 ORX66554.1 - 0.00025 21.4 0.4 0.00051 20.4 0.0 1.7 2 0 0 2 2 2 1 Acylphosphatase Fe_dep_repr_C PF02742.15 ORX66554.1 - 0.19 11.9 1.2 0.41 10.7 0.3 2.2 2 1 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Cgr1 PF03879.14 ORX66554.1 - 4.3 7.7 17.1 0.28 11.6 11.6 1.8 2 0 0 2 2 2 0 Cgr1 family tRNA-synt_1g PF09334.11 ORX66555.1 - 8.9e-131 436.2 0.1 1.7e-130 435.3 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX66555.1 - 2e-08 33.0 0.2 1.3e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX66555.1 - 0.0003 20.8 0.0 0.0013 18.7 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA Ribosomal_L35p PF01632.19 ORX66556.1 - 1.3e-11 44.8 1.6 1.5e-11 44.6 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 UreF PF01730.16 ORX66557.1 - 3.2e-10 40.7 2.1 1.5e-09 38.5 0.4 2.6 2 1 0 2 2 2 1 UreF Methyltransf_25 PF13649.6 ORX66558.1 - 9.1e-13 48.7 0.0 2.3e-12 47.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 ORX66558.1 - 2.1e-10 40.5 0.1 2.8e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 ORX66558.1 - 4.7e-10 39.4 0.0 7.1e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX66558.1 - 3.2e-09 37.3 0.0 6.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX66558.1 - 1.6e-06 28.1 0.0 2.4e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX66558.1 - 3e-06 26.7 0.0 4.3e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 ORX66558.1 - 4.4e-06 25.8 0.1 6.1e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 ORX66558.1 - 1.9e-05 25.3 0.0 3.3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX66558.1 - 8.7e-05 22.5 0.2 0.00014 21.8 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX66558.1 - 0.00011 21.9 0.1 0.00017 21.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 ORX66558.1 - 0.0016 17.8 0.1 0.0029 16.9 0.1 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 ORX66558.1 - 0.005 16.2 0.1 0.0076 15.6 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX66558.1 - 0.0089 16.1 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 ORX66558.1 - 0.011 15.4 0.2 0.017 14.9 0.2 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 ORX66558.1 - 0.02 14.9 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ORX66558.1 - 0.024 14.4 0.1 0.04 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 ORX66558.1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase DOT1 PF08123.13 ORX66558.1 - 0.098 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_24 PF13578.6 ORX66558.1 - 0.13 13.3 0.0 0.25 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ORX66558.1 - 0.26 10.7 3.0 0.16 11.3 0.8 1.9 2 1 0 2 2 2 0 Tellurite resistance protein TehB Aminotran_1_2 PF00155.21 ORX66559.1 - 2.8e-12 46.5 0.0 1e-11 44.7 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Cyclin_N PF00134.23 ORX66560.1 - 2.8e-12 46.5 0.1 4.2e-12 45.9 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX66560.1 - 1.2e-11 45.2 3.6 5.2e-11 43.2 0.1 2.2 2 0 0 2 2 2 1 Cyclin IMUP PF15761.5 ORX66560.1 - 1.3 9.8 6.7 0.13 13.0 2.0 1.7 2 0 0 2 2 2 0 Immortalisation up-regulated protein eIF-6 PF01912.18 ORX66561.1 - 2.4e-68 229.4 2.9 2.7e-48 164.0 0.3 2.4 2 1 1 3 3 3 2 eIF-6 family DUF3169 PF11368.8 ORX66563.1 - 0.06 12.9 0.3 0.064 12.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Fimbrillin_C PF15495.6 ORX66565.1 - 0.17 12.3 0.0 0.7 10.4 0.0 1.9 2 0 0 2 2 2 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal Dimer_Tnp_Tn5 PF02281.16 ORX66567.1 - 0.19 11.4 0.0 0.61 9.8 0.0 1.7 2 0 0 2 2 2 0 Transposase Tn5 dimerisation domain FAD_binding_1 PF00667.20 ORX66568.1 - 6e-29 101.2 0.0 9.6e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX66568.1 - 2.3e-22 79.8 0.1 8.4e-22 77.9 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX66568.1 - 1.4e-12 48.2 0.0 3.1e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ORX66568.1 - 0.0014 18.9 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain DUF2518 PF10726.9 ORX66568.1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of function (DUF2518) V-SNARE_C PF12352.8 ORX66569.1 - 8.1e-05 22.8 5.7 0.0036 17.6 1.4 2.6 2 1 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus DUF5089 PF17002.5 ORX66569.1 - 0.0021 18.0 14.4 0.063 13.1 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF5089) DUF4715 PF15835.5 ORX66569.1 - 0.054 13.6 0.3 0.27 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) LCIB_C_CA PF18599.1 ORX66569.1 - 0.093 12.0 0.0 1.5 8.1 0.0 2.1 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases APG6_N PF17675.1 ORX66569.1 - 0.86 10.1 15.6 4.2 7.9 2.7 3.1 3 0 0 3 3 3 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 ORX66569.1 - 1.5 6.6 6.3 1.8 6.4 6.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Chorion_3 PF05387.11 ORX66569.1 - 6 6.4 7.9 9.4 5.8 7.9 1.3 1 0 0 1 1 1 0 Chorion family 3 Peripla_BP_2 PF01497.18 ORX66570.1 - 0.021 14.4 0.0 0.086 12.4 0.0 1.9 2 0 0 2 2 2 0 Periplasmic binding protein DUF5484 PF17583.2 ORX66570.1 - 0.94 9.2 6.2 18 5.1 0.0 3.9 3 1 1 4 4 4 0 Family of unknown function (DUF5484) Sld5 PF05916.11 ORX66571.1 - 0.00022 21.7 0.3 0.00042 20.8 0.3 1.5 1 1 0 1 1 1 1 GINS complex protein NNMT_PNMT_TEMT PF01234.17 ORX66571.1 - 0.07 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Ank_2 PF12796.7 ORX66573.1 - 6.6e-28 97.1 4.0 2e-09 37.9 0.3 5.1 3 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX66573.1 - 2.3e-20 72.6 4.7 0.0012 19.3 0.0 6.8 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX66573.1 - 2.8e-17 61.0 5.7 0.17 12.6 0.0 10.2 11 1 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 ORX66573.1 - 3.4e-15 55.7 17.5 0.67 10.5 0.0 9.3 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 ORX66573.1 - 2.3e-12 46.9 15.2 0.0061 16.8 0.2 7.4 4 2 5 9 9 9 4 Ankyrin repeats (many copies) RabGAP-TBC PF00566.18 ORX66574.1 - 2e-21 76.6 0.0 4e-06 26.6 0.0 3.2 3 0 0 3 3 3 3 Rab-GTPase-TBC domain PPI_Ypi1 PF07491.11 ORX66575.1 - 6.7e-25 86.7 1.7 6.7e-25 86.7 1.7 2.3 2 0 0 2 2 2 1 Protein phosphatase inhibitor MFMR_assoc PF16596.5 ORX66575.1 - 1.5 9.3 9.3 0.18 12.3 0.7 2.2 2 0 0 2 2 2 0 Disordered region downstream of MFMR Cu-oxidase_3 PF07732.15 ORX66576.1 - 4.6e-34 117.0 0.4 1.4e-32 112.2 0.1 3.0 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX66576.1 - 3.3e-23 82.5 0.0 1.1e-22 80.9 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX66576.1 - 5.5e-17 61.8 6.6 7.6e-13 48.4 0.7 4.2 3 2 1 4 4 4 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX66577.1 - 7e-35 119.6 0.7 1.1e-33 115.7 0.0 2.6 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX66577.1 - 1.3e-32 112.4 3.5 2.6e-31 108.2 0.7 3.0 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX66577.1 - 1.7e-22 80.3 0.0 1.9e-18 67.1 0.0 3.4 3 0 0 3 3 3 3 Multicopper oxidase DUF4548 PF15081.6 ORX66577.1 - 0.011 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Nse4_C PF08743.10 ORX66578.1 - 2.3e-29 101.5 0.5 5.2e-29 100.4 0.1 1.8 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 ORX66578.1 - 8.7e-08 32.2 0.1 1.7e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Transferase PF02458.15 ORX66579.1 - 5.2e-21 74.8 0.0 4.2e-13 48.7 0.0 2.0 2 0 0 2 2 2 2 Transferase family LETM1 PF07766.13 ORX66581.1 - 2e-95 319.2 3.2 2e-95 319.2 3.2 1.8 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 ORX66581.1 - 0.0079 15.9 0.0 0.037 13.8 0.0 2.2 2 0 0 2 2 2 1 SAP domain TMEM119 PF15724.5 ORX66581.1 - 4.1 7.4 13.3 8.1 6.4 13.3 1.4 1 0 0 1 1 1 0 TMEM119 family FAD_binding_1 PF00667.20 ORX66582.1 - 1.1e-13 51.3 0.0 5.8e-10 39.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Flavodoxin_1 PF00258.25 ORX66582.1 - 1e-07 32.2 0.0 2.1e-06 28.0 0.0 2.4 1 1 1 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX66582.1 - 0.0003 21.4 0.4 0.0021 18.7 0.4 2.4 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ORX66582.1 - 0.013 15.8 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain DUF4860 PF16152.5 ORX66583.1 - 0.055 13.3 0.3 0.78 9.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4860) DUF1729 PF08354.10 ORX66584.1 - 9.5e-112 373.4 0.0 5.2e-111 371.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX66584.1 - 3e-48 165.0 0.0 1.9e-47 162.3 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX66584.1 - 1.7e-46 158.5 0.0 3.5e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX66584.1 - 9.9e-42 142.9 0.2 1.9e-41 142.0 0.2 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX66584.1 - 3.3e-27 94.5 0.1 8e-27 93.2 0.1 1.6 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX66584.1 - 3.5e-26 91.8 0.0 8.7e-26 90.5 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX66584.1 - 2.4e-20 73.2 0.1 5.2e-20 72.1 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX66584.1 - 2.3e-16 60.3 0.0 5.6e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX66584.1 - 1.9e-14 53.7 0.1 6.4e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX66584.1 - 3.1e-08 33.8 0.0 4.3e-07 30.1 0.0 2.5 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX66584.1 - 0.00078 19.5 0.1 0.0019 18.2 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta ACP_syn_III PF08545.10 ORX66584.1 - 0.0096 15.8 0.7 0.2 11.6 0.2 3.0 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III HOCHOB PF17943.1 ORX66584.1 - 0.2 12.4 1.7 20 5.9 0.2 2.7 2 0 0 2 2 2 0 Homeobox-cysteine loop-homeobox Transferase PF02458.15 ORX66585.1 - 4.1e-13 48.8 0.1 2.9e-08 32.8 0.3 2.7 2 1 0 2 2 2 2 Transferase family PEX-2N PF09263.10 ORX66585.1 - 0.015 15.6 0.1 0.03 14.6 0.1 1.4 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal SgrT PF15894.5 ORX66585.1 - 0.061 13.3 0.8 5.8 7.0 0.1 2.6 2 0 0 2 2 2 0 Inhibitor of glucose uptake transporter SgrT p450 PF00067.22 ORX66586.1 - 2.9e-61 207.6 0.0 3.9e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AAA_25 PF13481.6 ORX66587.1 - 4.8e-23 81.7 0.0 1e-22 80.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ORX66587.1 - 1.6e-16 60.5 0.0 2.4e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ORX66587.1 - 1.2e-08 34.6 0.0 2.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_16 PF13191.6 ORX66587.1 - 1.2e-05 25.8 0.1 0.00041 20.8 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX66587.1 - 1.8e-05 25.0 0.0 5.7e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX66587.1 - 0.0029 17.2 0.1 0.0053 16.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ORX66587.1 - 0.003 18.1 0.3 0.012 16.2 0.1 2.3 2 1 1 3 3 3 1 ABC transporter AAA PF00004.29 ORX66587.1 - 0.0059 17.0 0.3 0.5 10.8 0.1 2.8 1 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ORX66587.1 - 0.021 13.9 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 ORX66587.1 - 0.022 14.7 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Toprim_2 PF13155.6 ORX66587.1 - 0.025 15.0 0.0 0.099 13.1 0.0 2.0 1 0 0 1 1 1 0 Toprim-like AAA_23 PF13476.6 ORX66587.1 - 0.042 14.3 0.1 0.096 13.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX66587.1 - 0.08 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Toprim_4 PF13662.6 ORX66587.1 - 0.096 13.2 0.0 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 Toprim domain PX PF00787.24 ORX66589.1 - 1.5e-25 89.4 0.0 1.7e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 PX domain HSM3_C PF18794.1 ORX66591.1 - 0.052 13.1 0.0 0.073 12.7 0.0 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, C terminal domain Aa_trans PF01490.18 ORX66593.1 - 4e-47 160.8 40.7 4.6e-47 160.6 40.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ANAPC4_WD40 PF12894.7 ORX66594.1 - 1.2e-20 73.5 2.9 1e-05 25.8 0.0 5.1 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX66594.1 - 1.5e-13 51.0 4.9 0.02 15.8 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 ORX66594.1 - 2.7e-09 37.2 0.0 0.00051 20.0 0.0 3.7 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ORX66594.1 - 0.00069 18.8 0.1 0.048 12.7 0.0 2.4 2 1 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ORX66594.1 - 0.0015 17.2 0.0 0.0057 15.2 0.0 1.9 2 1 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ORX66594.1 - 0.0015 18.4 0.2 0.083 12.9 0.0 2.4 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Vps16_N PF04841.13 ORX66594.1 - 0.0044 15.8 0.0 0.047 12.4 0.0 2.3 2 1 1 3 3 3 1 Vps16, N-terminal region IKI3 PF04762.12 ORX66594.1 - 0.0051 14.9 1.4 0.038 12.0 0.2 2.5 2 1 0 3 3 3 1 IKI3 family WD40_like PF17005.5 ORX66594.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 WD40-like domain E_Pc_C PF06752.12 ORX66594.1 - 0.2 11.7 0.3 5.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus TF_Zn_Ribbon PF08271.12 ORX66596.1 - 3.4e-05 23.3 2.7 6.4e-05 22.4 2.7 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 ORX66596.1 - 0.0045 16.7 2.3 0.0079 15.9 2.3 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain TFIIB PF00382.19 ORX66596.1 - 0.056 13.5 0.7 0.9 9.6 0.2 3.0 2 1 1 3 3 3 0 Transcription factor TFIIB repeat DZR PF12773.7 ORX66596.1 - 0.059 13.4 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ORX66596.1 - 2.3 8.1 5.0 22 4.9 5.0 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Zw10 PF06248.13 ORX66597.1 - 8.3e-40 136.9 0.4 2.6e-39 135.2 0.4 1.7 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Vps53_N PF04100.12 ORX66597.1 - 0.024 13.6 1.0 0.049 12.6 1.0 1.5 1 0 0 1 1 1 0 Vps53-like, N-terminal Dsl1_C PF11989.8 ORX66597.1 - 0.064 13.0 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal Vps54_N PF10475.9 ORX66597.1 - 0.14 11.4 2.1 0.28 10.5 2.1 1.4 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex HEAT_2 PF13646.6 ORX66597.1 - 0.27 11.6 6.4 2.5 8.6 0.3 3.4 4 0 0 4 4 4 0 HEAT repeats BAR_2 PF10455.9 ORX66598.1 - 1.2e-32 113.3 3.7 6.7e-26 91.1 0.3 2.1 1 1 1 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 ORX66598.1 - 2.6e-24 86.2 3.1 3.2e-24 85.9 3.1 1.1 1 0 0 1 1 1 1 BAR domain TBCC_N PF16752.5 ORX66598.1 - 0.0061 17.0 3.6 0.0065 16.9 0.7 2.2 2 0 0 2 2 2 1 Tubulin-specific chaperone C N-terminal domain Csm2_III-A PF03750.13 ORX66598.1 - 0.055 14.3 0.6 7.5 7.4 0.0 2.5 2 1 0 2 2 2 0 Csm2 Type III-A DUF4398 PF14346.6 ORX66598.1 - 0.056 14.1 2.6 0.056 14.1 2.6 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4398) Com_YlbF PF06133.11 ORX66598.1 - 0.66 10.6 4.8 0.97 10.1 0.9 2.6 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA DASH_Hsk3 PF08227.11 ORX66599.1 - 2.6e-07 30.9 2.5 3.4e-07 30.5 2.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like LPP PF04728.13 ORX66599.1 - 0.017 15.5 0.1 0.027 14.9 0.1 1.3 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF4041 PF13250.6 ORX66599.1 - 0.066 13.1 0.3 0.091 12.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) Lactamase_B_4 PF13691.6 ORX66599.1 - 0.078 12.7 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 tRNase Z endonuclease DASH_Dad1 PF08649.10 ORX66599.1 - 0.087 13.0 2.2 0.13 12.4 2.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad1 Bap31_Bap29_C PF18035.1 ORX66599.1 - 0.1 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Cyclin_N PF00134.23 ORX66600.1 - 3.2e-44 149.7 0.1 7e-44 148.6 0.1 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ORX66600.1 - 1.6e-16 60.5 0.2 6.1e-16 58.6 0.0 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain PRKCSH PF07915.13 ORX66603.1 - 2.7e-09 37.9 0.1 7.5e-09 36.5 0.1 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 ORX66603.1 - 0.07 12.8 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein CD34_antigen PF06365.12 ORX66604.1 - 0.0021 17.7 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family Syndecan PF01034.20 ORX66604.1 - 0.0085 16.0 0.3 0.02 14.8 0.3 1.5 1 0 0 1 1 1 1 Syndecan domain Yip1 PF04893.17 ORX66604.1 - 0.01 15.6 0.4 0.028 14.2 0.1 1.8 2 0 0 2 2 2 0 Yip1 domain PIRT PF15099.6 ORX66604.1 - 0.029 13.9 0.1 0.048 13.2 0.1 1.3 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Glycophorin_A PF01102.18 ORX66604.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycophorin A DUF2681 PF10883.8 ORX66604.1 - 0.27 11.7 0.6 0.59 10.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) HAD_2 PF13419.6 ORX66605.1 - 2.1e-20 73.6 0.0 2.9e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX66605.1 - 8.6e-14 52.3 0.6 1.3e-09 38.7 0.1 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX66605.1 - 1.1e-06 28.6 0.3 2.4e-06 27.5 0.3 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like ADH_zinc_N PF00107.26 ORX66605.1 - 0.012 15.6 0.2 0.025 14.6 0.2 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase HAD PF12710.7 ORX66605.1 - 0.053 13.9 0.1 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3884 PF13024.6 ORX66605.1 - 0.11 12.1 0.0 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3884) Lipase_3 PF01764.25 ORX66606.1 - 3.5e-37 127.4 0.0 4.5e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX66606.1 - 0.00029 20.5 0.2 0.00077 19.1 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.7 ORX66606.1 - 0.037 13.8 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 ORX66606.1 - 0.038 14.6 0.0 0.042 14.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX66606.1 - 0.076 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX66606.1 - 0.083 12.5 0.6 0.88 9.2 0.5 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold MFS_1 PF07690.16 ORX66607.1 - 7.7e-30 104.0 54.1 4.1e-29 101.6 53.9 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX66607.1 - 3.8e-12 45.8 12.2 3.8e-12 45.8 12.2 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 ORX66607.1 - 7.3e-12 44.5 25.0 1.1e-11 44.0 25.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Urb2 PF10441.9 ORX66608.1 - 1.5e-21 77.3 0.0 1.2e-20 74.3 0.0 2.7 2 1 0 2 2 2 1 Urb2/Npa2 family CHAP PF05257.16 ORX66609.1 - 9e-14 51.8 4.7 2e-13 50.7 4.7 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX66609.1 - 9.3e-08 32.2 0.2 2.3e-07 31.0 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain Phage_lysozyme PF00959.19 ORX66610.1 - 2.3e-10 40.9 0.0 3.7e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX66610.1 - 6.1e-08 32.8 0.2 1.9e-07 31.2 0.2 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 ORX66610.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Catalase PF00199.19 ORX66611.1 - 2.1e-197 655.8 0.2 2.5e-197 655.6 0.2 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ORX66611.1 - 5.5e-18 64.9 0.0 1.2e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Pkinase PF00069.25 ORX66612.1 - 3.5e-73 246.2 0.0 4.3e-73 245.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66612.1 - 1.7e-46 158.6 0.0 2.2e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX66612.1 - 3.7e-11 42.9 0.2 4.7e-10 39.3 0.0 2.0 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX66612.1 - 1.6e-05 23.9 0.0 2.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX66612.1 - 0.026 14.5 0.2 1.1 9.1 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 ORX66612.1 - 0.043 13.5 0.1 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ssl1 PF04056.14 ORX66613.1 - 5.5e-74 248.2 0.0 7.7e-74 247.7 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 ORX66613.1 - 6.4e-16 58.9 0.1 3.3e-15 56.7 0.0 2.1 3 0 0 3 3 3 1 von Willebrand factor type A domain C1_4 PF07975.12 ORX66613.1 - 4.8e-14 52.3 25.5 6e-14 52.0 12.0 3.3 3 1 0 3 3 3 2 TFIIH C1-like domain VWA PF00092.28 ORX66613.1 - 0.00026 21.3 0.0 0.00052 20.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.21 ORX66613.1 - 0.0075 16.5 6.8 0.0075 16.5 6.8 2.6 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain zf-HIT PF04438.16 ORX66613.1 - 0.01 15.7 5.9 0.01 15.7 5.9 3.2 4 0 0 4 4 4 0 HIT zinc finger Tfb4 PF03850.14 ORX66613.1 - 0.013 15.1 6.5 0.45 10.0 6.6 2.3 2 1 0 2 2 2 0 Transcription factor Tfb4 DZR PF12773.7 ORX66613.1 - 4.2 7.5 24.3 2.6 8.1 5.3 3.2 2 1 0 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 ORX66615.1 - 6.9e-70 235.4 0.0 1.3e-69 234.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66615.1 - 6.1e-46 156.8 0.0 7.6e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX66615.1 - 1e-05 25.0 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX66615.1 - 3.5e-05 23.3 0.2 0.0003 20.2 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX66615.1 - 0.0011 18.9 0.6 0.011 15.6 0.5 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX66615.1 - 0.0018 17.1 0.0 0.0026 16.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX66615.1 - 0.058 12.3 0.0 0.094 11.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain YchF-GTPase_C PF06071.13 ORX66616.1 - 1.2e-23 83.1 0.1 3e-23 81.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ORX66616.1 - 1e-22 80.4 0.0 2.2e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX66616.1 - 1.4e-07 31.2 0.0 3.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX66616.1 - 0.00063 19.8 0.0 0.73 9.9 0.1 2.6 1 1 1 2 2 2 2 Dynamin family DUF2829 PF11195.8 ORX66616.1 - 0.0037 17.5 0.1 0.0079 16.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2829) MeaB PF03308.16 ORX66616.1 - 0.0062 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 ORX66616.1 - 0.15 11.9 0.0 5.9 6.6 0.0 2.3 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF1631 PF07793.11 ORX66618.1 - 0.5 8.7 5.6 0.61 8.4 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) CDC27 PF09507.10 ORX66618.1 - 0.67 9.3 13.4 0.79 9.1 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 ORX66618.1 - 0.79 9.5 4.1 1 9.1 4.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MFS_1 PF07690.16 ORX66620.1 - 4.8e-17 61.9 52.5 1.6e-10 40.4 13.9 2.7 3 0 0 3 3 3 2 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 ORX66620.1 - 0.012 15.6 1.6 0.012 15.6 1.6 5.0 4 2 2 6 6 6 0 Putative Actinobacterial Holin-X, holin superfamily III TrbC PF04956.13 ORX66620.1 - 0.017 15.3 1.4 0.017 15.3 1.4 3.5 3 2 0 3 3 3 0 TrbC/VIRB2 family Mtc PF03820.17 ORX66620.1 - 0.37 9.8 2.4 0.21 10.6 0.3 1.6 2 0 0 2 2 2 0 Tricarboxylate carrier BRAP2 PF07576.12 ORX66622.1 - 4.2e-31 107.1 0.0 9.2e-31 106.0 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ORX66622.1 - 5.6e-19 68.2 0.3 1.2e-18 67.1 0.3 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 ORX66622.1 - 0.00054 20.2 6.7 0.0016 18.8 6.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX66622.1 - 0.00073 19.3 4.4 0.0018 18.0 4.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX66622.1 - 0.00074 19.8 5.2 0.0019 18.4 5.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX66622.1 - 0.016 15.0 4.8 0.04 13.8 4.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tup_N PF08581.10 ORX66622.1 - 0.024 14.9 2.3 0.024 14.9 2.3 2.2 2 0 0 2 2 2 0 Tup N-terminal zf-ANAPC11 PF12861.7 ORX66622.1 - 0.03 14.3 2.5 0.066 13.3 2.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DASH_Dad4 PF08650.10 ORX66622.1 - 0.035 14.1 0.2 0.081 12.9 0.2 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad4 zf-RING_11 PF17123.5 ORX66622.1 - 0.065 13.0 3.2 0.22 11.3 3.2 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 ORX66622.1 - 0.12 12.3 5.2 0.3 11.1 5.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain DUF4407 PF14362.6 ORX66622.1 - 1.3 8.3 13.8 2 7.7 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 ORX66622.1 - 1.7 9.3 7.8 8.8 7.0 0.7 3.0 2 2 0 2 2 2 0 SlyX zf-RING_UBOX PF13445.6 ORX66622.1 - 8.1 6.6 7.9 35 4.5 7.6 2.1 1 1 1 2 2 2 0 RING-type zinc-finger Inhibitor_I78 PF11720.8 ORX66623.1 - 2.2e-08 34.0 0.0 3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX66623.1 - 0.0041 17.8 0.1 0.0083 16.8 0.1 1.5 2 0 0 2 2 2 1 Potato inhibitor I family Pre-SET PF05033.16 ORX66625.1 - 0.032 14.9 2.4 0.062 14.0 2.4 1.5 1 0 0 1 1 1 0 Pre-SET motif Cu-oxidase_2 PF07731.14 ORX66627.1 - 1.5e-37 128.4 4.2 2.3e-33 114.9 0.1 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX66627.1 - 1.2e-35 122.1 4.2 3.8e-34 117.2 0.5 3.5 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX66627.1 - 2.4e-35 122.0 0.0 9.6e-30 103.8 0.0 3.4 3 0 0 3 3 3 3 Multicopper oxidase DNApol_Exo PF18136.1 ORX66627.1 - 0.059 12.5 0.0 0.092 11.9 0.0 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Cupredoxin_1 PF13473.6 ORX66627.1 - 0.1 12.7 0.0 3.8 7.7 0.0 2.7 2 0 0 2 2 2 0 Cupredoxin-like domain CLP_protease PF00574.23 ORX66628.1 - 8.2e-84 280.0 0.0 1.1e-83 279.7 0.0 1.1 1 0 0 1 1 1 1 Clp protease PITH PF06201.13 ORX66629.1 - 2.1e-41 141.7 0.0 2.6e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 PITH domain Reprolysin_2 PF13574.6 ORX66629.1 - 1.2 9.0 7.8 1.9 8.3 7.8 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SelP_N PF04592.14 ORX66629.1 - 4.5 6.6 10.2 6.5 6.1 10.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Hist_deacetyl PF00850.19 ORX66630.1 - 1.2e-82 277.9 0.1 1.5e-82 277.5 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain SGP PF17228.2 ORX66630.1 - 0.094 13.6 2.7 7.4 7.5 0.9 2.5 2 0 0 2 2 2 0 Sulphur globule protein CAP PF00188.26 ORX66631.1 - 0.0059 17.4 0.0 0.023 15.5 0.0 1.9 2 0 0 2 2 2 1 Cysteine-rich secretory protein family EMP24_GP25L PF01105.24 ORX66632.1 - 7.5e-42 143.3 0.0 8.6e-42 143.1 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD FlxA PF14282.6 ORX66632.1 - 0.025 14.6 1.1 0.041 13.9 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein CarboxypepD_reg PF13620.6 ORX66632.1 - 0.035 14.4 0.1 0.062 13.6 0.1 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain LPMO_10 PF03067.15 ORX66633.1 - 3.3e-07 31.2 0.0 3.9e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading LPMO_10 PF03067.15 ORX66634.1 - 2.4e-09 38.1 0.1 4.7e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading DUF908 PF06012.12 ORX66634.1 - 1.5 8.2 4.3 4.8 6.5 4.4 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) LPMO_10 PF03067.15 ORX66635.1 - 1.2e-07 32.6 0.0 2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX66635.1 - 2.4e-05 24.4 2.7 0.0026 17.7 0.4 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 61 SOG2 PF10428.9 ORX66635.1 - 6.9 5.7 11.3 8.4 5.5 11.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 ORX66635.1 - 9.7 4.7 8.6 12 4.4 8.6 1.1 1 0 0 1 1 1 0 Hamartin protein LPMO_10 PF03067.15 ORX66636.1 - 4.7e-08 33.9 0.0 5.9e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX66636.1 - 0.00042 20.3 0.4 0.00077 19.5 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 GPI-anchored PF10342.9 ORX66636.1 - 0.011 16.5 0.1 0.026 15.3 0.1 1.6 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family LPMO_10 PF03067.15 ORX66637.1 - 7.2e-08 33.3 0.9 2.1e-07 31.8 0.0 2.0 2 1 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX66637.1 - 1.7e-05 24.9 2.6 0.0031 17.5 0.4 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 61 PRCC PF10253.9 ORX66637.1 - 1.4 9.6 7.6 2.2 9.0 7.6 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting SOG2 PF10428.9 ORX66637.1 - 1.6 7.8 10.5 1.8 7.6 10.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DEC-1_N PF04625.13 ORX66637.1 - 9.9 5.1 7.6 13 4.6 7.6 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LPMO_10 PF03067.15 ORX66638.1 - 1.2e-05 26.1 0.1 1.5e-05 25.7 0.1 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading GPI-anchored PF10342.9 ORX66638.1 - 0.0033 18.2 0.1 0.015 16.1 0.0 2.1 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glyco_hydro_61 PF03443.14 ORX66638.1 - 0.0092 15.9 0.2 0.035 14.1 0.2 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 ORX66639.1 - 6.4e-06 27.0 0.1 8.4e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX66639.1 - 0.039 13.9 1.1 2.2 8.1 0.1 2.7 2 1 1 3 3 3 0 Glycosyl hydrolase family 61 GPI-anchored PF10342.9 ORX66639.1 - 0.09 13.5 0.0 0.36 11.6 0.0 2.0 1 1 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family tRNA-synt_2c PF01411.19 ORX66640.1 - 4e-222 738.6 0.0 5.4e-222 738.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ORX66640.1 - 3.5e-16 59.0 0.1 1.2e-15 57.3 0.0 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ORX66640.1 - 7.2e-12 45.9 6.8 2e-11 44.5 6.8 1.8 1 0 0 1 1 1 1 DHHA1 domain Acyltransferase PF01553.21 ORX66641.1 - 4.6e-10 39.3 0.0 2.1e-08 33.9 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase SUIM_assoc PF16619.5 ORX66641.1 - 0.023 14.7 4.9 0.056 13.5 4.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Rhomboid PF01694.22 ORX66643.1 - 4.7e-06 26.7 5.5 7.3e-06 26.1 5.5 1.3 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 ORX66643.1 - 0.019 15.5 2.1 0.019 15.5 2.1 1.8 1 1 1 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 ORX66643.1 - 0.13 12.2 7.9 0.22 11.4 7.9 1.4 1 1 0 1 1 1 0 Der1-like family Pre-SET PF05033.16 ORX66644.1 - 0.035 14.8 2.4 0.062 14.0 2.4 1.4 1 0 0 1 1 1 0 Pre-SET motif SMC_Nse1 PF07574.13 ORX66647.1 - 3.2e-24 85.9 0.1 4.2e-23 82.3 0.1 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 ORX66647.1 - 8.3e-05 22.8 11.3 0.00017 21.8 11.3 1.5 1 0 0 1 1 1 1 RING-like domain PHD PF00628.29 ORX66647.1 - 0.046 13.6 10.6 0.1 12.5 10.6 1.6 1 0 0 1 1 1 0 PHD-finger zf-ANAPC11 PF12861.7 ORX66647.1 - 0.57 10.3 4.8 1.2 9.3 4.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 ORX66647.1 - 9.8 6.2 11.3 26 4.8 7.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Cu-oxidase PF00394.22 ORX66648.1 - 5.5e-12 46.1 0.0 2.6e-11 43.9 0.0 2.0 1 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX66648.1 - 1.4e-09 38.0 0.1 5.4e-09 36.1 0.1 1.9 2 0 0 2 2 2 1 Multicopper oxidase PPC PF04151.15 ORX66648.1 - 0.0024 18.9 0.3 0.0024 18.9 0.3 2.0 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain YfkD PF14167.6 ORX66648.1 - 0.049 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 YfkD-like protein Cu-oxidase_2 PF07731.14 ORX66648.1 - 0.081 12.7 0.3 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Multicopper oxidase DnaJ PF00226.31 ORX66652.1 - 1.1e-15 57.5 1.3 2.2e-15 56.5 1.3 1.5 1 0 0 1 1 1 1 DnaJ domain IQ PF00612.27 ORX66653.1 - 2.9e-06 26.6 9.8 0.006 16.3 1.2 3.1 2 0 0 2 2 2 2 IQ calmodulin-binding motif RabGAP-TBC PF00566.18 ORX66654.1 - 3.9e-32 111.6 0.0 5.3e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1631 PF07793.11 ORX66655.1 - 0.54 8.6 9.0 0.63 8.4 9.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) DUF4904 PF16247.5 ORX66660.1 - 0.068 13.0 0.1 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4904) ABC_tran PF00005.27 ORX66661.1 - 4.8e-18 66.0 0.0 7.5e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX66661.1 - 4.8e-10 39.5 0.4 7.1e-10 39.0 0.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX66661.1 - 0.031 13.7 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain CAP PF00188.26 ORX66691.1 - 0.00012 23.0 0.1 0.0002 22.2 0.1 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 ORX66693.1 - 2.4e-12 47.8 0.2 3.6e-12 47.2 0.2 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Phos_pyr_kin PF08543.12 ORX66694.1 - 4.3e-20 72.1 0.0 5.6e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ORX66694.1 - 9.8e-10 38.2 0.5 8e-07 28.6 0.0 2.4 2 0 0 2 2 2 2 pfkB family carbohydrate kinase DUF3701 PF12482.8 ORX66698.1 - 0.053 13.6 2.2 0.1 12.6 2.2 1.6 1 1 0 1 1 1 0 Phage integrase protein CN_hydrolase PF00795.22 ORX66703.1 - 1.1e-37 129.9 0.0 1.7e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 ORX66703.1 - 9.6e-14 51.1 0.0 3.4e-13 49.3 0.0 1.8 1 1 0 1 1 1 1 NAD synthase Nrap_D6 PF17407.2 ORX66704.1 - 0.2 11.9 0.0 4 7.7 0.0 2.3 2 0 0 2 2 2 0 Nrap protein domain 6 DKCLD PF08068.12 ORX66705.1 - 5e-32 109.8 2.9 3.9e-30 103.7 0.8 3.1 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.18 ORX66705.1 - 1.9e-14 54.3 5.9 2.2e-12 47.6 0.2 2.7 3 0 0 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 ORX66705.1 - 1.7e-08 34.3 0.2 5.6e-08 32.6 0.2 2.0 1 1 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 ORX66705.1 - 3.4e-08 33.5 0.1 6.4e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain SAPS PF04499.15 ORX66705.1 - 0.34 9.6 6.1 0.45 9.3 6.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein eIF3_subunit PF08597.10 ORX66705.1 - 0.36 10.7 28.7 0.55 10.1 28.7 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit VIR_N PF15912.5 ORX66705.1 - 0.57 9.7 10.9 1 8.9 10.9 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal GAGA_bind PF06217.12 ORX66705.1 - 0.81 9.9 11.3 1.3 9.2 11.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 ORX66705.1 - 1.6 7.0 13.5 2.1 6.6 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S49_N PF08496.10 ORX66705.1 - 1.8 8.6 14.4 4 7.5 14.4 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 ORX66705.1 - 1.9 8.3 19.1 2.8 7.7 19.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ORX66705.1 - 3.6 7.6 34.7 5.9 6.9 34.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 MCM_bind PF09739.9 ORX66705.1 - 8.9 4.6 13.7 13 4.1 13.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor YqfQ PF14181.6 ORX66705.1 - 9.4 6.4 15.0 15 5.7 15.0 1.4 1 0 0 1 1 1 0 YqfQ-like protein GrpB PF04229.14 ORX66706.1 - 1.2e-37 129.5 0.0 1.4e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 GrpB protein HAMP PF00672.25 ORX66707.1 - 0 1040.0 157.4 3.1e-08 33.9 0.1 44.9 43 0 0 43 43 42 41 HAMP domain Baculo_PEP_C PF04513.12 ORX66707.1 - 6.9e-53 178.4 301.6 0.012 15.6 7.8 38.1 2 2 36 41 41 41 32 Baculovirus polyhedron envelope protein, PEP, C terminus APG17 PF04108.12 ORX66707.1 - 7.1e-45 153.8 56.0 8.1e-05 21.9 1.4 19.3 1 1 19 22 22 22 20 Autophagy protein Apg17 ApoLp-III PF07464.11 ORX66707.1 - 2.2e-39 134.9 189.8 0.025 14.7 2.7 37.4 4 4 33 42 42 42 26 Apolipophorin-III precursor (apoLp-III) Syntaxin_2 PF14523.6 ORX66707.1 - 3.5e-34 117.2 88.5 4.4 7.7 0.0 37.2 20 10 11 39 39 38 5 Syntaxin-like protein HATPase_c PF02518.26 ORX66707.1 - 4.1e-31 107.8 0.1 1.3e-30 106.2 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4279 PF14106.6 ORX66707.1 - 2.5e-29 101.8 0.0 49 4.2 0.0 30.1 37 0 0 37 37 37 0 Domain of unknown function (DUF4279) WXG100 PF06013.12 ORX66707.1 - 2.5e-27 94.9 118.4 0.16 12.2 0.2 39.8 38 6 2 42 42 40 5 Proteins of 100 residues with WXG Response_reg PF00072.24 ORX66707.1 - 5.3e-18 65.2 0.9 2.5e-14 53.4 0.0 3.9 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 ORX66707.1 - 5.4e-16 58.4 1.8 1.1e-14 54.2 0.5 4.6 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain UDPG_MGDP_dh PF00984.19 ORX66707.1 - 8.3e-12 45.2 31.1 1.8e+02 2.4 0.0 26.8 34 0 0 34 34 30 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain GLE1 PF07817.13 ORX66707.1 - 2.5e-11 43.3 39.5 20 4.3 0.0 24.2 7 5 22 30 30 30 0 GLE1-like protein Apolipoprotein PF01442.18 ORX66707.1 - 5.7e-10 39.4 69.0 1.7 8.5 0.7 20.2 6 3 6 15 15 14 4 Apolipoprotein A1/A4/E domain SpoIIID PF12116.8 ORX66707.1 - 2.2e-06 27.6 109.3 15 5.8 0.1 33.2 38 0 0 38 38 38 0 Stage III sporulation protein D AAA_13 PF13166.6 ORX66707.1 - 4.5e-05 22.3 93.6 1 7.9 0.3 17.8 3 3 16 21 21 21 9 AAA domain DUF3829 PF12889.7 ORX66707.1 - 9.3e-05 22.0 115.2 3.7 6.9 0.1 26.6 10 6 15 31 31 31 2 Protein of unknown function (DUF3829) Rab5-bind PF09311.11 ORX66707.1 - 0.00014 21.4 133.4 2 7.8 0.1 31.7 7 4 28 37 37 37 6 Rabaptin-like protein HTH_6 PF01418.17 ORX66707.1 - 0.0029 17.6 25.5 53 3.9 0.0 19.8 24 0 0 24 24 20 0 Helix-turn-helix domain, rpiR family PhoLip_ATPase_N PF16209.5 ORX66708.1 - 2.2e-17 62.5 7.3 6.2e-17 61.1 7.3 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ORX66708.1 - 1.6e-15 58.0 1.8 5.3e-15 56.3 1.8 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PhoLip_ATPase_C PF16212.5 ORX66708.1 - 1.1e-10 41.8 23.7 4.1e-09 36.6 3.9 3.8 3 1 2 5 5 5 3 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 ORX66708.1 - 1.7e-07 31.2 0.0 1.2e-05 25.3 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX66708.1 - 0.0013 18.5 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AA_permease_C PF13906.6 ORX66708.1 - 3.9 7.6 13.2 1.2 9.3 9.3 2.2 2 0 0 2 2 2 0 C-terminus of AA_permease RSN1_7TM PF02714.15 ORX66709.1 - 2.9e-28 98.9 14.3 4.2e-18 65.6 8.3 3.1 2 1 1 3 3 3 3 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ORX66709.1 - 3e-08 34.1 0.0 4.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Anoctamin PF04547.12 ORX66709.1 - 0.03 13.2 0.8 0.048 12.5 0.8 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel RSN1_TM PF13967.6 ORX66710.1 - 7.1e-07 29.1 0.0 8.4e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport ABC_tran PF00005.27 ORX66711.1 - 1.9e-50 170.9 0.0 3e-30 105.5 0.0 3.6 3 1 0 3 3 3 2 ABC transporter RsgA_GTPase PF03193.16 ORX66711.1 - 2.7e-08 33.9 0.1 0.017 15.1 0.1 3.4 3 0 0 3 3 3 2 RsgA GTPase SMC_N PF02463.19 ORX66711.1 - 1.1e-07 31.5 2.4 0.021 14.2 0.0 3.8 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX66711.1 - 1.5e-07 31.0 0.4 0.0096 15.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX66711.1 - 2.4e-06 27.6 2.7 0.018 15.1 0.1 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase ABC_membrane PF00664.23 ORX66711.1 - 7.1e-06 25.9 3.7 1.2e-05 25.1 3.7 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region IstB_IS21 PF01695.17 ORX66711.1 - 2.5e-05 24.1 0.1 0.087 12.6 0.0 3.5 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.6 ORX66711.1 - 8.8e-05 22.9 0.0 1.1 9.6 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 ORX66711.1 - 0.00037 20.9 0.8 1.7 9.0 0.0 3.8 4 0 0 4 4 3 1 RNA helicase DUF815 PF05673.13 ORX66711.1 - 0.00052 19.3 0.4 0.84 8.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_23 PF13476.6 ORX66711.1 - 0.00069 20.2 0.3 1.7 9.1 0.2 2.3 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 ORX66711.1 - 0.0015 17.8 0.9 0.72 9.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin T2SSE PF00437.20 ORX66711.1 - 0.0016 17.6 0.0 0.19 10.7 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.23 ORX66711.1 - 0.0017 18.5 2.4 0.28 11.2 0.5 2.4 2 0 0 2 2 2 1 Dynamin family MeaB PF03308.16 ORX66711.1 - 0.0023 16.9 0.5 0.13 11.3 0.1 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 ORX66711.1 - 0.0035 17.9 0.3 2.1 8.9 0.0 3.1 3 0 0 3 3 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ORX66711.1 - 0.0044 16.4 0.4 2.5 7.4 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA PF00004.29 ORX66711.1 - 0.0044 17.4 0.0 3.5 8.1 0.0 3.0 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 ORX66711.1 - 0.0059 16.8 1.0 1.1 9.5 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 ORX66711.1 - 0.0061 16.1 0.6 0.56 9.7 0.2 2.5 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 ORX66711.1 - 0.0071 16.0 0.1 6.4 6.4 0.1 2.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TrwB_AAD_bind PF10412.9 ORX66711.1 - 0.013 14.4 1.2 0.97 8.3 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 ORX66711.1 - 0.014 15.6 0.9 9.6 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 ORX66711.1 - 0.016 15.3 3.8 0.5 10.4 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 ORX66711.1 - 0.017 14.6 0.5 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 ORX66711.1 - 0.018 15.1 0.3 4 7.5 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 ORX66711.1 - 0.025 14.0 0.7 3.9 6.8 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_PrkA PF08298.11 ORX66711.1 - 0.065 12.1 0.0 1.6 7.5 0.0 2.4 2 0 0 2 2 2 0 PrkA AAA domain PduV-EutP PF10662.9 ORX66711.1 - 0.094 12.5 1.9 13 5.5 0.1 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ORX66711.1 - 0.11 12.1 1.9 1.1 8.8 0.4 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activat PF00158.26 ORX66711.1 - 0.12 12.1 0.3 1.3 8.7 0.0 2.4 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_21 PF13304.6 ORX66711.1 - 0.13 12.0 1.5 24 4.6 0.1 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system GTP_EFTU PF00009.27 ORX66711.1 - 0.21 11.1 0.2 19 4.7 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 ORX66711.1 - 0.27 10.4 1.8 41 3.2 0.0 3.4 4 0 0 4 4 4 0 NB-ARC domain Ploopntkinase3 PF18751.1 ORX66711.1 - 0.29 11.0 1.0 7.3 6.5 0.1 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 dNK PF01712.19 ORX66711.1 - 0.57 10.0 2.4 7 6.4 0.4 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase NACHT PF05729.12 ORX66711.1 - 0.75 9.7 2.2 15 5.5 0.3 2.7 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 ORX66711.1 - 0.84 9.9 3.2 9.3 6.5 0.6 2.5 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 ORX66711.1 - 0.87 9.3 4.1 10 5.8 1.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 ORX66711.1 - 1.4 8.6 2.8 13 5.4 0.0 2.4 3 0 0 3 3 2 0 AAA ATPase domain efThoc1 PF11957.8 ORX66712.1 - 8.5e-44 150.0 0.0 2.3e-33 115.6 0.0 2.8 2 1 1 3 3 3 2 THO complex subunit 1 transcription elongation factor PSD2 PF07624.11 ORX66712.1 - 0.046 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) Mg_trans_NIPA PF05653.14 ORX66713.1 - 8e-10 38.3 17.3 2.5e-08 33.4 17.3 2.8 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX66713.1 - 7.7e-05 22.9 0.6 7.7e-05 22.9 0.6 3.8 3 2 1 4 4 4 1 EamA-like transporter family NOG1_N PF17835.1 ORX66714.1 - 1.2e-53 181.3 0.7 1.2e-53 181.3 0.7 2.0 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 ORX66714.1 - 1.3e-26 92.2 0.1 4.4e-26 90.4 0.1 2.0 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 ORX66714.1 - 2.3e-20 72.3 0.4 5.1e-20 71.2 0.4 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 ORX66714.1 - 2.8e-09 37.0 0.1 1.9e-08 34.4 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX66714.1 - 0.00052 19.6 0.0 0.0032 17.0 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B SUA5 PF03481.13 ORX66714.1 - 0.021 15.4 0.3 0.067 13.8 0.3 1.9 1 0 0 1 1 1 0 Putative GTP-binding controlling metal-binding RsgA_GTPase PF03193.16 ORX66714.1 - 0.04 13.8 0.0 3.4 7.5 0.0 2.9 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 ORX66714.1 - 0.093 12.8 0.7 0.46 10.5 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AOX PF01786.17 ORX66715.1 - 7.2e-52 176.1 5.0 3.3e-50 170.7 5.0 2.4 1 1 0 1 1 1 1 Alternative oxidase TPR_21 PF09976.9 ORX66715.1 - 0.046 13.4 0.3 0.1 12.3 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain DUF383 PF04063.14 ORX66716.1 - 1e-64 217.7 0.0 4.9e-64 215.5 0.0 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 ORX66716.1 - 2.8e-18 65.5 0.3 6.8e-18 64.3 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) HEAT_2 PF13646.6 ORX66716.1 - 0.0013 19.1 0.0 0.038 14.4 0.0 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 ORX66716.1 - 0.024 14.8 0.9 32 5.1 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat RICTOR_V PF14668.6 ORX66716.1 - 0.065 13.5 0.0 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Peptidase_C48 PF02902.19 ORX66717.1 - 1.2e-21 77.6 0.1 1.7e-21 77.1 0.1 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PCI PF01399.27 ORX66718.1 - 1.6e-09 38.2 4.4 2.4e-06 28.0 0.1 3.0 2 1 1 3 3 3 2 PCI domain TPR_14 PF13428.6 ORX66718.1 - 0.15 13.0 5.5 56 4.9 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX66718.1 - 9.6 6.2 6.7 5.6 6.9 0.3 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Raptor_N PF14538.6 ORX66719.1 - 1.4e-53 180.8 0.0 3.2e-53 179.6 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain adh_short PF00106.25 ORX66721.1 - 9.5e-66 221.0 14.3 2e-36 125.3 1.9 3.4 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66721.1 - 2.6e-53 181.0 11.0 1.6e-29 103.1 0.8 3.3 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ORX66721.1 - 1.3e-26 92.6 0.0 3e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 ORX66721.1 - 9.2e-25 87.6 6.0 1.5e-17 64.1 0.9 3.3 3 0 0 3 3 3 2 KR domain MaoC_dehydrat_N PF13452.6 ORX66721.1 - 6.9e-09 35.9 0.0 2.4e-06 27.7 0.0 2.7 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase THF_DHG_CYH_C PF02882.19 ORX66721.1 - 0.00097 18.5 0.4 0.11 11.9 0.0 2.5 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF543 PF04418.12 ORX66721.1 - 0.096 12.7 5.4 1.4 9.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) 2-Hacid_dh_C PF02826.19 ORX66721.1 - 0.096 12.0 0.6 0.74 9.1 0.1 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PglL_A PF15864.5 ORX66721.1 - 1.3 8.9 6.6 9.6 6.0 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase 3HCDH_N PF02737.18 ORX66721.1 - 7.3 6.4 8.3 16 5.3 1.4 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ATG16 PF08614.11 ORX66722.1 - 0.0024 18.1 33.4 0.089 13.0 13.4 2.5 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) DUF948 PF06103.11 ORX66722.1 - 0.17 12.1 8.7 3.2 8.1 0.3 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) OmpH PF03938.14 ORX66722.1 - 0.22 11.9 29.7 0.75 10.1 12.7 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Fez1 PF06818.15 ORX66722.1 - 0.62 10.5 28.0 1.2 9.5 26.6 1.9 1 1 1 2 2 2 0 Fez1 Filament PF00038.21 ORX66722.1 - 0.88 9.1 30.6 0.076 12.6 6.2 3.1 1 1 2 3 3 3 0 Intermediate filament protein Spc29 PF17082.5 ORX66722.1 - 1.3 8.8 13.7 0.36 10.7 2.5 2.6 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF1515 PF07439.11 ORX66722.1 - 2.7 8.1 11.5 0.67 10.0 1.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) HMMR_N PF15905.5 ORX66722.1 - 2.8 7.3 28.9 0.78 9.2 15.2 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal UPF0242 PF06785.11 ORX66722.1 - 3 7.9 34.4 4 7.5 7.9 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 ORX66722.1 - 4.6 7.3 12.1 0.86 9.6 5.4 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PKcGMP_CC PF16808.5 ORX66722.1 - 7.8 6.4 10.0 13 5.8 0.7 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FAM184 PF15665.5 ORX66722.1 - 8.6 6.1 31.5 0.63 9.8 9.1 2.2 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B Endosulfine PF04667.17 ORX66723.1 - 4.8e-25 87.5 0.2 5.7e-25 87.3 0.2 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Peptidase_M24_C PF16188.5 ORX66723.1 - 0.033 14.2 0.0 0.043 13.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 EcsB PF05975.12 ORX66723.1 - 0.19 10.6 0.1 0.21 10.4 0.1 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB VCBS PF13517.6 ORX66724.1 - 8e-31 106.4 18.1 9e-13 48.6 2.6 5.7 5 2 2 7 7 7 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ORX66724.1 - 2.7e-19 68.9 7.4 0.0024 17.9 0.0 6.6 6 0 0 6 6 6 6 FG-GAP repeat TcdB_toxin_midN PF12256.8 ORX66724.1 - 0.00017 21.0 3.5 4.7 6.5 0.0 5.6 4 2 2 6 6 6 1 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 ORX66724.1 - 0.0036 17.5 2.6 18 5.6 0.0 5.1 6 0 0 6 6 6 1 Dockerin type I domain Itfg2 PF15907.5 ORX66724.1 - 0.042 12.9 0.1 6.7 5.6 0.0 2.9 3 0 0 3 3 3 0 Integrin-alpha FG-GAP repeat-containing protein 2 PliI PF16743.5 ORX66724.1 - 0.089 12.5 0.2 7 6.4 0.0 3.8 5 1 0 5 5 5 0 Periplasmic lysozyme inhibitor of I-type lysozyme EF-hand_5 PF13202.6 ORX66724.1 - 0.39 10.3 0.1 0.39 10.3 0.1 5.0 6 0 0 6 6 6 0 EF hand adh_short PF00106.25 ORX66726.1 - 5.1e-33 114.2 0.1 6.6e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66726.1 - 5.8e-28 98.0 0.1 8.4e-28 97.5 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX66726.1 - 6.3e-09 36.0 0.2 8.7e-09 35.5 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX66726.1 - 0.0087 15.5 0.4 0.015 14.7 0.4 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX66726.1 - 0.15 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DHHC PF01529.20 ORX66730.1 - 0.014 15.5 5.0 0.014 15.5 5.0 1.9 2 0 0 2 2 2 0 DHHC palmitoyltransferase MAPEG PF01124.18 ORX66730.1 - 0.39 10.6 3.7 0.67 9.9 3.7 1.4 1 0 0 1 1 1 0 MAPEG family Inv-AAD PF18785.1 ORX66731.1 - 3.2e-32 111.1 0.7 1.2e-31 109.3 0.7 1.7 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 ORX66731.1 - 3.2e-21 75.1 0.7 4.1e-21 74.7 0.7 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX66731.1 - 2.3e-11 43.6 0.8 2.9e-11 43.3 0.8 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 ORX66731.1 - 9.1e-05 22.4 0.0 0.00023 21.1 0.0 1.7 1 1 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 ORX66731.1 - 9.1e-05 22.6 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 APOBEC3 NAD1 PF18778.1 ORX66731.1 - 0.0058 16.7 0.0 0.0077 16.3 0.0 1.3 1 1 0 1 1 1 1 Novel AID APOBEC clade 1 XOO_2897-deam PF14440.6 ORX66731.1 - 0.035 14.2 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase APOBEC2 PF18772.1 ORX66731.1 - 0.044 13.8 0.0 0.067 13.2 0.0 1.4 1 1 0 1 1 1 0 APOBEC2 Sedlin_N PF04628.13 ORX66732.1 - 6.5e-26 91.0 0.0 7.5e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 ORX66732.1 - 0.0038 17.2 0.1 0.27 11.1 0.1 2.2 1 1 0 1 1 1 1 Sybindin-like family MCR_C PF04609.12 ORX66732.1 - 0.053 12.6 0.1 0.14 11.2 0.1 1.8 1 1 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Aldedh PF00171.22 ORX66733.1 - 1.6e-95 320.3 3.3 6.5e-95 318.3 3.3 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family POB3_N PF17292.2 ORX66734.1 - 1.3e-21 76.8 0.0 5e-20 71.7 0.0 2.6 2 1 0 2 2 2 1 POB3-like N-terminal PH domain SSrecog PF03531.14 ORX66734.1 - 2e-21 75.7 0.0 1.2e-20 73.1 0.0 2.3 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 ORX66734.1 - 3.3e-16 59.5 0.0 2.9e-14 53.3 0.0 2.5 1 1 0 1 1 1 1 Histone chaperone Rttp106-like FlaC_arch PF05377.11 ORX66735.1 - 0.17 12.3 0.1 0.31 11.5 0.1 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CTP_transf_like PF01467.26 ORX66737.1 - 0.021 15.0 0.0 5 7.3 0.0 2.2 2 0 0 2 2 2 0 Cytidylyltransferase-like DUF1748 PF08520.10 ORX66738.1 - 0.0021 17.9 0.1 0.0063 16.4 0.1 1.9 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF1748) DALR_1 PF05746.15 ORX66739.1 - 0.0069 16.6 0.1 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain adh_short PF00106.25 ORX66740.1 - 9e-51 172.1 0.9 1.2e-50 171.7 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX66740.1 - 4.5e-39 134.4 2.2 5.3e-39 134.1 2.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX66740.1 - 5.8e-18 65.4 0.4 7.8e-18 65.0 0.4 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX66740.1 - 0.00023 20.7 3.8 0.00024 20.7 0.8 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ORX66740.1 - 0.00039 20.4 2.7 0.00067 19.6 2.7 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ORX66740.1 - 0.0018 17.5 0.1 0.0025 17.0 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 ORX66740.1 - 0.05 12.9 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ORX66740.1 - 0.071 13.2 0.1 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PP2C PF00481.21 ORX66741.1 - 1.4e-38 133.0 0.0 5.9e-37 127.7 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C FumaraseC_C PF10415.9 ORX66741.1 - 0.033 14.6 0.5 0.14 12.6 0.4 2.2 2 0 0 2 2 2 0 Fumarase C C-terminus DUF4602 PF15375.6 ORX66742.1 - 8.6e-05 22.9 15.6 8.6e-05 22.9 15.6 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4602) MFS_1 PF07690.16 ORX66743.1 - 5.8e-45 153.8 53.0 1.3e-44 152.6 53.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX66743.1 - 8.6e-10 37.7 29.1 1.5e-09 36.9 29.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX66743.1 - 7.3e-09 35.0 15.8 7.3e-09 35.0 15.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TMEM174 PF15029.6 ORX66743.1 - 1.3 8.7 3.2 0.74 9.5 0.3 1.9 1 1 1 2 2 2 0 Transmembrane protein 174 RMI1_N PF08585.12 ORX66744.1 - 1.9e-35 122.6 0.0 2.2e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein HTH_33 PF13592.6 ORX66744.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix AOX PF01786.17 ORX66745.1 - 4.4e-78 261.8 0.6 4.8e-78 261.6 0.6 1.0 1 0 0 1 1 1 1 Alternative oxidase Fe-S_biosyn PF01521.20 ORX66746.1 - 2.5e-14 53.4 0.0 4e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Holin_9 PF16936.5 ORX66747.1 - 0.022 14.9 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 Putative holin SecE PF00584.20 ORX66748.1 - 3.4e-13 49.3 0.0 5.3e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex HBB PF06777.11 ORX66748.1 - 0.2 11.3 0.0 0.22 11.2 0.0 1.1 1 0 0 1 1 1 0 Helical and beta-bridge domain eIF-1a PF01176.19 ORX66749.1 - 1.4e-20 72.8 0.1 1.9e-20 72.4 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 OTCace PF00185.24 ORX66750.1 - 4.9e-46 156.7 0.1 7.5e-46 156.1 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ORX66750.1 - 9.7e-45 152.2 0.0 1.4e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain FYVE PF01363.21 ORX66751.1 - 8.8e-11 41.8 12.8 8.8e-11 41.8 12.8 2.7 2 2 1 3 3 3 1 FYVE zinc finger GFA PF04828.14 ORX66751.1 - 2.3e-08 34.3 0.7 2.3e-08 34.3 0.7 3.0 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme FYVE_2 PF02318.16 ORX66751.1 - 0.015 15.5 4.1 0.015 15.5 4.1 2.2 3 0 0 3 3 3 0 FYVE-type zinc finger Arf PF00025.21 ORX66752.1 - 5.2e-46 156.3 0.4 6.4e-46 156.0 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ORX66752.1 - 4.3e-22 78.4 0.0 5.2e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66752.1 - 3.3e-18 66.0 0.0 4.9e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX66752.1 - 1e-11 44.6 0.0 1.3e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX66752.1 - 3.6e-10 39.6 0.0 4.3e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ORX66752.1 - 1.1e-08 34.7 0.6 2.1e-05 23.9 0.0 2.6 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ORX66752.1 - 1.2e-08 35.1 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ORX66752.1 - 0.0055 17.0 0.1 0.12 12.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX66752.1 - 0.019 14.5 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 ORX66752.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 ORX66752.1 - 0.036 13.7 0.1 4.7 6.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 ORX66752.1 - 0.041 14.0 0.1 1 9.4 0.1 2.2 1 1 1 2 2 2 0 Dynamin family VirE PF05272.11 ORX66752.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E FeoB_N PF02421.18 ORX66752.1 - 0.1 12.2 1.8 0.13 11.8 0.1 1.9 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.6 ORX66752.1 - 0.11 12.9 0.1 17 5.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 ORX66752.1 - 0.17 12.4 0.6 0.3 11.6 0.6 1.6 1 1 0 1 1 1 0 ABC transporter PLDc PF00614.22 ORX66753.1 - 9.4e-17 60.4 3.0 5.7e-10 39.0 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX66753.1 - 1.2e-13 51.1 0.1 0.00071 19.5 0.0 3.4 3 0 0 3 3 3 3 PLD-like domain PX PF00787.24 ORX66753.1 - 1.4e-11 44.4 0.3 5.4e-11 42.5 0.3 2.1 1 0 0 1 1 1 1 PX domain SR-25 PF10500.9 ORX66753.1 - 0.0013 18.4 1.5 0.0029 17.3 1.5 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein PH PF00169.29 ORX66753.1 - 0.012 16.1 0.5 0.049 14.1 0.4 2.0 2 0 0 2 2 2 0 PH domain Kelch_1 PF01344.25 ORX66757.1 - 8.6e-33 111.7 5.3 6.9e-09 35.2 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ORX66757.1 - 1.8e-31 107.9 7.6 6.3e-10 38.9 0.0 5.1 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX66757.1 - 1.3e-28 98.4 5.1 9.9e-08 31.8 0.0 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 ORX66757.1 - 3.8e-24 84.4 12.6 4.6e-09 36.3 0.0 5.8 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX66757.1 - 4.2e-24 84.0 8.8 4.3e-06 26.8 0.1 5.4 3 2 2 5 5 5 4 Kelch motif Kelch_2 PF07646.15 ORX66757.1 - 7.5e-24 82.8 8.0 3.9e-08 33.0 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Mt_ATP-synt_B PF05405.14 ORX66758.1 - 3e-44 150.5 10.8 3.6e-44 150.2 10.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SapB_1 PF05184.15 ORX66758.1 - 0.0015 18.5 0.1 0.0062 16.5 0.0 2.1 2 0 0 2 2 2 1 Saposin-like type B, region 1 D5_N PF08706.11 ORX66758.1 - 0.079 13.2 1.6 8.2 6.7 0.1 2.2 1 1 1 2 2 2 0 D5 N terminal like SIL1 PF16782.5 ORX66759.1 - 2.7e-06 26.8 0.0 3.1e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Arm PF00514.23 ORX66759.1 - 1 9.5 0.0 1 9.5 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat zf-met2 PF12907.7 ORX66760.1 - 1.3e-16 60.4 3.6 1.9e-16 59.9 3.6 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 ORX66760.1 - 1.6e-07 32.1 12.0 1.6e-07 32.1 12.0 1.6 2 0 0 2 2 2 1 4F5 protein family zf-C2H2_12 PF18658.1 ORX66760.1 - 0.018 14.6 2.0 0.025 14.2 2.0 1.2 1 0 0 1 1 1 0 Zinc-finger C2H2-type RRM_1 PF00076.22 ORX66761.1 - 1.1e-09 38.0 0.0 0.00032 20.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX66761.1 - 0.0075 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif HORMA PF02301.18 ORX66762.1 - 4.4e-23 82.0 0.0 6.9e-23 81.3 0.0 1.3 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 ORX66762.1 - 0.0012 18.7 0.1 0.002 18.0 0.1 1.4 1 1 0 1 1 1 1 Bacterial HORMA domain 2 F-box-like PF12937.7 ORX66763.1 - 0.0049 16.7 0.1 0.013 15.3 0.1 1.7 1 1 0 1 1 1 1 F-box-like p450 PF00067.22 ORX66765.1 - 2.6e-59 201.2 0.1 2e-28 99.4 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 Flavodoxin_1 PF00258.25 ORX66765.1 - 5.1e-20 72.1 0.0 9.8e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 ORX66765.1 - 2.8e-12 46.7 0.0 7.4e-12 45.3 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ORX66765.1 - 0.0012 19.5 0.0 0.0029 18.2 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain ERCC4 PF02732.15 ORX66766.1 - 9.8e-21 74.6 0.1 1.6e-20 73.9 0.1 1.4 1 0 0 1 1 1 1 ERCC4 domain Abhydrolase_1 PF00561.20 ORX66767.1 - 7.5e-27 94.6 0.0 3.6e-19 69.4 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX66767.1 - 1e-19 72.0 0.0 1.4e-19 71.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX66767.1 - 1e-11 44.5 0.3 2.4e-11 43.4 0.3 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 ORX66767.1 - 7.4e-06 25.8 0.7 0.015 15.0 0.4 2.3 1 1 0 2 2 2 2 PGAP1-like protein Thioesterase PF00975.20 ORX66767.1 - 0.00019 21.6 0.0 0.00028 21.1 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 ORX66767.1 - 0.0022 17.6 0.1 0.0045 16.5 0.1 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Esterase PF00756.20 ORX66767.1 - 0.0045 16.7 0.0 0.011 15.4 0.0 1.6 2 0 0 2 2 2 1 Putative esterase DLH PF01738.18 ORX66767.1 - 0.01 15.4 0.0 4.7 6.7 0.0 2.9 3 0 0 3 3 3 0 Dienelactone hydrolase family Ndr PF03096.14 ORX66767.1 - 0.014 14.1 0.0 0.02 13.6 0.0 1.4 1 1 0 1 1 1 0 Ndr family DUF2048 PF09752.9 ORX66767.1 - 0.02 14.0 0.5 1.7 7.7 0.1 2.2 2 1 0 2 2 2 0 Abhydrolase domain containing 18 Abhydrolase_5 PF12695.7 ORX66767.1 - 0.029 14.1 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3693 PF12472.8 ORX66767.1 - 0.44 10.2 1.6 0.55 9.9 0.2 1.8 2 0 0 2 2 2 0 Phage related protein RhoGAP PF00620.27 ORX66768.1 - 4.7e-36 123.9 0.0 1.4e-35 122.3 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX66768.1 - 1.2e-29 102.3 47.7 1.4e-13 50.9 5.2 4.6 4 0 0 4 4 4 4 LIM domain Calpain_u2 PF16648.5 ORX66768.1 - 0.099 13.1 0.7 0.26 11.8 0.7 1.6 1 0 0 1 1 1 0 Unstructured region on Calpain-3 ALMT PF11744.8 ORX66768.1 - 0.72 8.6 4.1 1.4 7.7 4.1 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DIE2_ALG10 PF04922.12 ORX66769.1 - 5.2e-81 272.9 4.1 5.8e-81 272.8 4.1 1.0 1 0 0 1 1 1 1 DIE2/ALG10 family DIE2_ALG10 PF04922.12 ORX66770.1 - 9.2e-37 127.2 12.4 1.1e-36 127.0 12.4 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family DUF1772 PF08592.11 ORX66770.1 - 0.0015 18.8 2.5 0.0015 18.8 2.5 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) ANAPC2 PF08672.11 ORX66771.1 - 1.5e-21 76.6 0.0 4.5e-21 75.1 0.0 1.9 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 ORX66771.1 - 1.3e-11 43.9 0.1 2.7e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 Cullin family M16C_assoc PF08367.11 ORX66773.1 - 8.2e-53 179.1 0.5 6.2e-37 127.1 0.1 2.2 2 0 0 2 2 2 2 Peptidase M16C associated Abhydrolase_1 PF00561.20 ORX66773.1 - 2.9e-15 56.6 0.2 4.4e-14 52.7 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX66773.1 - 2.8e-10 39.9 0.1 9.6e-10 38.1 0.1 1.8 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX66773.1 - 3.9e-10 40.7 0.4 3.1e-09 37.8 0.1 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_M16 PF00675.20 ORX66773.1 - 8.3e-05 22.6 1.2 0.00037 20.5 0.0 2.6 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX66773.1 - 0.00052 20.1 0.2 0.41 10.6 0.0 3.5 3 0 0 3 3 3 2 Peptidase M16 inactive domain Esterase PF00756.20 ORX66773.1 - 0.0035 17.0 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 ORX66773.1 - 0.0071 16.1 0.4 0.027 14.2 0.0 2.1 2 0 0 2 2 2 1 PGAP1-like protein OSCP PF00213.18 ORX66773.1 - 0.06 13.5 4.1 0.34 11.0 0.1 2.9 3 0 0 3 3 3 0 ATP synthase delta (OSCP) subunit Metallophos PF00149.28 ORX66775.1 - 1.6e-07 32.1 0.2 2.7e-07 31.3 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF812 PF05667.11 ORX66777.1 - 0.0028 16.6 2.0 0.0029 16.6 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF445 PF04286.12 ORX66777.1 - 0.081 12.7 1.5 0.14 11.9 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Epiglycanin_TR PF05647.11 ORX66777.1 - 0.5 10.3 19.0 0.075 13.0 1.5 2.5 2 0 0 2 2 2 0 Tandem-repeating region of mucin, epiglycanin-like SlyX PF04102.12 ORX66777.1 - 1.7 9.3 5.5 5 7.8 3.1 2.4 1 1 1 2 2 2 0 SlyX ADH_N PF08240.12 ORX66778.1 - 1.5e-16 60.3 1.4 1.5e-16 60.3 1.4 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX66778.1 - 1.5e-15 57.3 0.0 3e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ORX66778.1 - 1.9e-06 27.5 0.1 3.6e-06 26.6 0.1 1.4 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 ORX66778.1 - 0.00029 20.2 0.0 0.00052 19.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ORX66778.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IGFBP PF00219.18 ORX66778.1 - 1.5 9.6 7.3 0.93 10.2 0.3 3.1 3 0 0 3 3 3 0 Insulin-like growth factor binding protein FANCAA PF15146.6 ORX66779.1 - 0.078 12.1 1.1 0.17 10.9 0.3 1.7 1 1 1 2 2 2 0 Fanconi anemia-associated FlgM PF04316.13 ORX66780.1 - 0.012 15.9 0.1 0.057 13.8 0.1 2.2 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM SAP PF02037.27 ORX66780.1 - 0.084 12.6 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 SAP domain T2SSC PF11356.8 ORX66780.1 - 4.1 7.3 7.0 0.62 10.0 1.8 2.4 2 0 0 2 2 2 0 Type II secretion system protein C GCIP PF13324.6 ORX66783.1 - 3.3e-22 79.4 3.7 8.8e-22 78.0 3.7 1.6 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF5082 PF16888.5 ORX66783.1 - 0.028 14.7 0.3 0.52 10.6 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) DUF5333 PF17267.2 ORX66783.1 - 0.065 13.4 0.7 1.8 8.7 0.0 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5333) Homoserine_dh PF00742.19 ORX66785.1 - 3e-41 141.2 0.0 6.4e-41 140.2 0.0 1.5 1 1 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 ORX66785.1 - 1.9e-19 70.4 0.0 3.2e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F-box-like PF12937.7 ORX66786.1 - 0.00012 21.9 0.0 0.00042 20.1 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX66786.1 - 0.008 16.0 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain BRO1 PF03097.18 ORX66786.1 - 0.015 14.1 1.3 0.023 13.5 1.3 1.2 1 0 0 1 1 1 0 BRO1-like domain TPR_2 PF07719.17 ORX66786.1 - 0.02 15.0 0.7 0.02 15.0 0.7 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat RFX_DNA_binding PF02257.15 ORX66786.1 - 0.029 15.0 0.1 0.077 13.6 0.1 1.8 1 0 0 1 1 1 0 RFX DNA-binding domain TPR_1 PF00515.28 ORX66786.1 - 0.066 13.1 0.3 0.17 11.7 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX66786.1 - 0.11 13.4 1.5 0.3 12.0 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PEPCK_ATP PF01293.20 ORX66787.1 - 1.1e-203 677.1 0.0 1.5e-203 676.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF4679 PF15728.5 ORX66791.1 - 0.1 11.6 1.3 0.14 11.1 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Aldedh PF00171.22 ORX66792.1 - 9.1e-73 245.3 0.0 3e-70 237.0 0.0 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family HeH PF12949.7 ORX66792.1 - 0.0061 16.2 0.2 0.044 13.5 0.0 2.1 2 0 0 2 2 2 1 HeH/LEM domain SKG6 PF08693.10 ORX66794.1 - 0.16 11.4 0.7 0.36 10.3 0.4 1.9 1 1 0 1 1 1 0 Transmembrane alpha-helix domain Ras PF00071.22 ORX66797.1 - 2e-54 183.6 0.0 2.3e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX66797.1 - 2.7e-22 79.2 0.0 3.7e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX66797.1 - 4e-08 32.9 0.0 5.1e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX66797.1 - 0.0032 17.0 0.0 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX66797.1 - 0.2 11.6 0.0 1.6 8.6 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase S4 PF01479.25 ORX66798.1 - 1.9e-11 43.5 1.7 1.9e-11 43.5 1.7 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 ORX66798.1 - 3.8e-06 27.7 0.1 7.5e-06 26.8 0.1 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 ORX66799.1 - 1.2e-27 95.6 0.6 1.4e-27 95.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L21e Mito_carr PF00153.27 ORX66800.1 - 7e-59 195.8 1.2 1.5e-23 82.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Acyl-CoA_dh_2 PF08028.11 ORX66800.1 - 0.095 13.0 0.1 0.91 9.8 0.0 2.5 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain Utp21 PF04192.12 ORX66801.1 - 2.2e-63 213.9 0.0 3e-63 213.4 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 ORX66801.1 - 5.2e-20 71.4 20.6 1.2e-05 25.9 0.2 10.1 10 1 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66801.1 - 1.3e-12 47.9 0.1 9.4e-05 22.6 0.0 6.2 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX66801.1 - 3.4e-05 22.7 4.0 0.077 11.6 0.0 4.0 2 2 1 4 4 4 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ORX66801.1 - 0.004 16.8 0.8 4.2 6.9 0.0 2.8 2 2 1 3 3 3 3 PQQ-like domain ELYS-bb PF16687.5 ORX66801.1 - 0.019 13.6 0.0 1.8 7.1 0.0 2.8 1 1 2 3 3 3 0 beta-propeller of ELYS nucleoporin Hira PF07569.11 ORX66801.1 - 0.043 13.5 0.1 0.25 11.0 0.0 2.4 3 1 0 3 3 3 0 TUP1-like enhancer of split PQQ_3 PF13570.6 ORX66801.1 - 0.057 13.9 0.0 17 6.1 0.0 4.3 4 0 0 4 4 4 0 PQQ-like domain Cytochrom_D1 PF02239.16 ORX66801.1 - 0.11 11.0 1.6 5.5 5.4 0.0 3.4 3 1 1 4 4 4 0 Cytochrome D1 heme domain DZR PF12773.7 ORX66802.1 - 0.11 12.6 5.7 0.17 11.9 5.7 1.4 1 0 0 1 1 1 0 Double zinc ribbon ABA_GPCR PF12430.8 ORX66803.1 - 4.9e-35 120.9 9.2 4.9e-35 120.9 9.2 1.8 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 ORX66803.1 - 9.4e-16 57.7 0.0 2.1e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Hum_adeno_E3A PF05393.11 ORX66803.1 - 0.5 10.4 2.4 2.9 7.9 0.1 2.7 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein Sds3 PF08598.11 ORX66804.1 - 1.2e-06 28.7 19.7 2.2e-06 27.8 19.8 1.5 1 1 0 1 1 1 1 Sds3-like SGP PF17228.2 ORX66805.1 - 0.077 13.9 20.9 0.71 10.8 9.4 2.1 1 1 1 2 2 2 0 Sulphur globule protein OspD PF03207.13 ORX66805.1 - 0.39 10.0 3.3 1.2 8.5 3.4 1.7 1 1 0 1 1 1 0 Borrelia outer surface protein D (OspD) DUF3824 PF12868.7 ORX66806.1 - 0.0009 19.9 0.9 0.001 19.7 0.9 1.1 1 0 0 1 1 1 1 Domain of unknwon function (DUF3824) Ribosomal_60s PF00428.19 ORX66806.1 - 0.054 14.1 1.4 0.092 13.3 1.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Catalase PF00199.19 ORX66810.1 - 6.4e-184 611.4 0.2 2.8e-182 606.0 0.2 2.1 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ORX66810.1 - 2.1e-20 72.7 0.2 4.2e-20 71.7 0.2 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Myb_DNA-bind_7 PF15963.5 ORX66811.1 - 4.9e-22 77.6 1.0 8.6e-22 76.8 1.0 1.4 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 ORX66811.1 - 2.4e-09 37.3 0.0 5.1e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX66811.1 - 0.0023 18.2 0.1 0.004 17.4 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ORX66811.1 - 0.084 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 WD40 PF00400.32 ORX66812.1 - 1.6e-11 44.6 0.4 0.28 12.1 0.2 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat MRI PF15325.6 ORX66814.1 - 2 9.5 7.6 0.38 11.9 3.8 1.7 1 1 1 2 2 2 0 Modulator of retrovirus infection Basic PF01586.16 ORX66814.1 - 3.8 8.8 7.2 47 5.3 7.2 2.1 1 1 0 1 1 1 0 Myogenic Basic domain Ribosomal_L16 PF00252.18 ORX66815.1 - 8.3e-38 129.4 0.1 1.1e-37 129.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Glycos_transf_4 PF00953.21 ORX66816.1 - 1.6e-35 122.4 13.4 3.4e-35 121.4 13.4 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 4 UCH PF00443.29 ORX66817.1 - 5.4e-06 26.1 0.0 1.1e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase HEAT PF02985.22 ORX66819.1 - 1.3e-15 56.1 5.3 0.015 15.5 0.1 6.1 6 0 0 6 6 6 4 HEAT repeat HEAT_2 PF13646.6 ORX66819.1 - 2.8e-13 50.1 0.1 7.7e-06 26.2 0.0 4.9 3 2 2 5 5 5 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX66819.1 - 6.7e-08 33.0 0.6 0.84 10.3 0.0 5.0 3 2 1 4 4 4 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX66819.1 - 1.2e-06 28.7 0.4 0.014 15.4 0.0 3.2 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX66819.1 - 1.6e-06 28.5 0.5 0.021 15.4 0.1 4.7 3 1 1 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 ORX66819.1 - 0.00013 20.7 0.2 0.28 9.7 0.0 2.1 2 0 0 2 2 2 2 Adaptin N terminal region Cohesin_HEAT PF12765.7 ORX66819.1 - 0.44 10.9 3.0 28 5.2 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion STT3 PF02516.14 ORX66820.1 - 2.7e-113 379.5 18.3 1.3e-61 209.0 3.2 3.2 3 0 0 3 3 3 3 Oligosaccharyl transferase STT3 subunit zinc_ribbon_15 PF17032.5 ORX66821.1 - 4.5e-06 27.3 1.1 8.5e-06 26.4 1.1 1.4 1 0 0 1 1 1 1 zinc-ribbon family DUF1180 PF06679.12 ORX66821.1 - 0.0051 17.3 1.3 0.0063 17.0 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Zn_Tnp_IS1595 PF12760.7 ORX66821.1 - 0.81 9.7 6.2 2.7 8.1 6.2 1.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain p450 PF00067.22 ORX66822.1 - 1.9e-45 155.5 0.0 4.6e-45 154.2 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 RNA_pol_Rpb1_2 PF00623.20 ORX66823.1 - 7.5e-74 247.5 0.4 1.6e-73 246.4 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.17 ORX66823.1 - 1.7e-68 231.0 0.0 2.6e-68 230.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 ORX66823.1 - 4.3e-67 226.7 0.0 7.8e-67 225.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ORX66823.1 - 1.1e-28 99.3 0.0 2.6e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 ORX66823.1 - 6.4e-24 84.7 0.0 3.7e-23 82.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 MFS_1 PF07690.16 ORX66824.1 - 3.3e-16 59.2 35.6 1.2e-06 27.8 8.7 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily OATP PF03137.20 ORX66824.1 - 0.019 13.3 3.6 0.036 12.3 3.6 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tom6 PF17112.5 ORX66824.1 - 0.3 10.6 5.2 5.4 6.6 0.5 2.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal DUF202 PF02656.15 ORX66824.1 - 4.5 7.8 17.0 5.7 7.5 0.9 4.8 4 2 1 5 5 5 0 Domain of unknown function (DUF202) MFS_1 PF07690.16 ORX66825.1 - 7.5e-08 31.7 36.8 3.5e-06 26.2 16.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MMS19_N PF14500.6 ORX66826.1 - 7.1e-66 222.5 4.9 1.3e-62 211.7 0.0 5.1 5 1 0 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 ORX66826.1 - 2.9e-41 142.0 6.9 1.8e-38 132.7 0.6 3.0 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal THF_DHG_CYH PF00763.23 ORX66827.1 - 5.5e-24 84.7 0.1 8.8e-24 84.0 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 ORX66827.1 - 2.7e-12 46.3 0.1 1.2e-10 40.9 0.1 2.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DAP3 PF10236.9 ORX66828.1 - 4.9e-49 167.2 0.0 6.7e-49 166.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 ORX66828.1 - 5.6e-06 26.8 0.2 8.7e-06 26.2 0.2 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ORX66828.1 - 0.0078 16.6 0.0 0.05 14.0 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ORX66828.1 - 0.0088 16.0 0.0 0.094 12.6 0.0 2.5 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ORX66828.1 - 0.031 14.0 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX66828.1 - 0.038 13.7 0.1 0.095 12.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.31 ORX66831.1 - 1.5e-14 53.8 0.0 2.2e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pex2_Pex12 PF04757.14 ORX66831.1 - 0.017 14.7 0.2 0.027 14.1 0.2 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region GTP_CH_N PF12471.8 ORX66832.1 - 4.1e-60 202.8 0.1 1.1e-59 201.4 0.0 1.6 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 ORX66832.1 - 2.1e-17 63.2 0.0 3e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF3824 PF12868.7 ORX66833.1 - 0.002 18.8 1.5 0.002 18.8 1.5 1.9 1 1 1 2 2 2 1 Domain of unknwon function (DUF3824) C2 PF00168.30 ORX66836.1 - 3.6e-21 75.4 0.0 8.8e-21 74.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 ORX66836.1 - 3.2e-08 34.2 0.2 0.028 15.0 0.0 4.1 3 0 0 3 3 3 3 Putative heavy-metal-binding PfkB PF00294.24 ORX66837.1 - 5.8e-37 127.6 0.1 6.9e-37 127.4 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase MTS PF05175.14 ORX66838.1 - 4.1e-08 33.0 0.0 1.4e-07 31.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ORX66838.1 - 0.0016 17.9 0.0 0.087 12.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 ORX66838.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 ORX66838.1 - 0.027 15.5 0.0 0.064 14.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 ORX66838.1 - 0.046 14.5 0.1 0.12 13.1 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ORX66838.1 - 0.055 14.2 0.0 0.21 12.3 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ORX66838.1 - 0.12 12.2 0.0 0.24 11.1 0.0 1.4 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 ORX66838.1 - 0.14 12.8 0.0 1.9 9.2 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain DUF2263 PF10021.9 ORX66839.1 - 2e-22 80.1 0.0 3.6e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Myosin_head PF00063.21 ORX66840.1 - 4.2e-233 775.5 0.0 5.6e-233 775.0 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ORX66840.1 - 2.1e-33 115.6 0.0 3.9e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_2 PF07653.17 ORX66840.1 - 0.00012 21.7 0.1 0.00036 20.2 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX66840.1 - 0.0015 18.1 0.9 0.0035 16.9 0.9 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX66840.1 - 0.0073 16.1 0.6 0.025 14.4 0.6 2.0 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.6 ORX66840.1 - 0.016 15.6 0.1 0.06 13.7 0.1 2.0 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 ORX66840.1 - 0.022 14.3 2.9 2.8 7.4 0.0 2.8 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain Zeta_toxin PF06414.12 ORX66840.1 - 0.058 12.7 0.1 0.37 10.1 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 ORX66840.1 - 0.076 13.3 0.1 0.25 11.6 0.1 1.8 1 0 0 1 1 1 0 AAA domain IQ PF00612.27 ORX66840.1 - 0.096 12.5 6.2 0.59 10.1 1.2 2.7 1 1 1 2 2 2 0 IQ calmodulin-binding motif NACHT PF05729.12 ORX66840.1 - 0.13 12.1 0.2 0.51 10.2 0.2 1.9 2 0 0 2 2 2 0 NACHT domain DnaGprimase_HBD PF16730.5 ORX66840.1 - 0.7 10.0 2.8 0.36 10.9 0.2 1.8 2 0 0 2 2 2 0 DnaG-primase C-terminal, helicase-binding domain ABC_tran PF00005.27 ORX66840.1 - 0.92 10.0 4.1 2.3 8.7 0.3 2.6 2 0 0 2 2 2 0 ABC transporter GSHPx PF00255.19 ORX66841.1 - 7.9e-44 147.7 0.1 1e-43 147.3 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ORX66841.1 - 0.00016 21.5 0.0 0.00049 20.0 0.0 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX66841.1 - 0.00077 19.2 0.1 0.0019 17.9 0.1 1.8 1 1 0 1 1 1 1 Redoxin DUF5126 PF17166.4 ORX66841.1 - 0.0044 16.9 0.1 0.036 13.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5126) Gar1 PF04410.14 ORX66842.1 - 1.6e-27 96.2 2.8 6.3e-27 94.2 0.6 2.6 1 1 1 2 2 2 1 Gar1/Naf1 RNA binding region Peptidase_S49_N PF08496.10 ORX66842.1 - 0.065 13.3 2.2 0.11 12.5 2.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Transposase_21 PF02992.14 ORX66842.1 - 0.19 11.0 0.1 0.29 10.3 0.1 1.2 1 0 0 1 1 1 0 Transposase family tnp2 AF-4 PF05110.13 ORX66842.1 - 4.9 5.1 18.7 0.066 11.3 5.9 2.0 2 0 0 2 2 2 0 AF-4 proto-oncoprotein MFS_1 PF07690.16 ORX66843.1 - 6.1e-48 163.5 62.9 2.7e-38 131.8 23.0 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX66843.1 - 3.7e-18 65.3 26.8 4.4e-16 58.4 26.8 2.1 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX66843.1 - 6.1e-14 51.7 11.5 6.1e-14 51.7 11.5 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter MerC PF03203.14 ORX66843.1 - 0.00027 21.4 3.5 0.00027 21.4 3.5 4.4 2 1 1 3 3 3 1 MerC mercury resistance protein TMEM100 PF16311.5 ORX66843.1 - 1.4 8.5 8.4 0.23 11.1 0.8 3.0 3 0 0 3 3 3 0 Transmembrane protein 100 YfhO PF09586.10 ORX66843.1 - 3.4 5.8 8.5 5.5 5.1 8.5 1.5 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Cellulase PF00150.18 ORX66844.1 - 1.5e-08 34.5 0.0 3.5e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBFD_NFYB_HMF PF00808.23 ORX66846.1 - 1.4e-29 102.1 0.3 1.9e-29 101.7 0.3 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX66846.1 - 9.4e-06 26.0 0.2 1.2e-05 25.7 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX66846.1 - 0.00019 21.5 0.0 0.00024 21.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 ORX66846.1 - 0.002 18.1 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 ORX66846.1 - 0.0032 17.5 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-X PF09415.10 ORX66846.1 - 0.033 14.5 0.1 0.065 13.6 0.1 1.5 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TFIID_20kDa PF03847.13 ORX66846.1 - 0.039 14.4 0.2 0.78 10.3 0.1 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Mito_morph_reg PF14972.6 ORX66847.1 - 0.25 10.9 1.9 0.36 10.4 1.5 1.3 1 1 0 1 1 1 0 Mitochondrial morphogenesis regulator FAD-SLDH PF12318.8 ORX66848.1 - 0.5 10.4 0.0 0.5 10.4 0.0 2.5 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF743 PF05332.11 ORX66850.1 - 0.052 13.6 2.9 0.15 12.1 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF743) DUF3540 PF12059.8 ORX66850.1 - 0.07 13.0 1.7 0.11 12.3 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) DUF3209 PF11483.8 ORX66850.1 - 0.14 12.6 2.8 0.29 11.6 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) Alk_phosphatase PF00245.20 ORX66851.1 - 2.9e-102 342.7 0.0 3.4e-102 342.5 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX66851.1 - 0.0029 17.0 0.0 0.01 15.2 0.1 1.8 2 0 0 2 2 2 1 Metalloenzyme superfamily KH_6 PF15985.5 ORX66852.1 - 7.4e-17 61.4 0.0 1.2e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 ORX66852.1 - 4.8e-08 32.8 0.0 8.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Pex19 PF04614.12 ORX66853.1 - 3.4e-23 82.7 2.4 3.6e-23 82.6 2.4 1.0 1 0 0 1 1 1 1 Pex19 protein family Atg14 PF10186.9 ORX66854.1 - 4.7e-24 85.1 2.4 1.7e-22 79.9 2.4 2.0 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 PspA_IM30 PF04012.12 ORX66854.1 - 0.007 16.0 3.3 0.007 16.0 3.3 2.3 2 1 1 3 3 3 1 PspA/IM30 family zf-B_box PF00643.24 ORX66854.1 - 0.74 10.0 3.8 2.2 8.5 3.8 1.8 1 0 0 1 1 1 0 B-box zinc finger FUSC PF04632.12 ORX66854.1 - 7 5.1 10.6 13 4.2 10.0 1.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family PPTA PF01239.22 ORX66855.1 - 7.8e-35 117.6 6.6 5.1e-07 29.2 0.1 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat RAI1 PF08652.11 ORX66856.1 - 6.5e-21 74.3 0.0 1.2e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Peptidase_S39 PF02122.15 ORX66856.1 - 0.028 13.9 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase S39 His_biosynth PF00977.21 ORX66857.1 - 1.1e-44 152.6 0.1 6.3e-43 146.9 0.1 2.6 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 ORX66857.1 - 1.4e-17 64.1 0.0 2.1e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 ORX66857.1 - 1.1e-08 34.9 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ORX66857.1 - 5.7e-08 32.8 0.0 4.6e-07 29.9 0.0 2.2 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Dus PF01207.17 ORX66857.1 - 0.064 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Peptidase_C26 PF07722.13 ORX66857.1 - 0.072 12.8 0.7 0.41 10.4 0.7 2.1 1 1 0 1 1 1 0 Peptidase C26 RNA_pol_Rpc34 PF05158.12 ORX66858.1 - 1.8e-83 280.7 0.0 2.6e-83 280.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit MarR PF01047.22 ORX66858.1 - 0.0019 18.1 0.9 0.0097 15.8 0.2 2.3 2 0 0 2 2 2 1 MarR family Penicillinase_R PF03965.16 ORX66858.1 - 0.0023 18.3 1.5 0.01 16.2 0.0 2.7 3 1 1 4 4 4 1 Penicillinase repressor TrmB PF01978.19 ORX66858.1 - 0.0029 17.5 0.4 0.7 9.8 0.1 2.8 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 ORX66858.1 - 0.029 14.3 0.0 0.083 12.9 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family RPA_C PF08784.11 ORX66858.1 - 0.045 14.4 0.5 0.65 10.7 0.1 2.4 2 0 0 2 2 2 0 Replication protein A C terminal Pro_isomerase PF00160.21 ORX66859.1 - 2.2e-51 174.3 0.0 4.3e-51 173.3 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 ORX66859.1 - 4.8e-07 29.8 0.0 1.3e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 ORX66859.1 - 8e-06 25.4 5.5 0.00016 21.1 0.1 3.0 2 1 0 2 2 2 1 Rtf2 RING-finger zf-Nse PF11789.8 ORX66859.1 - 0.00068 19.4 0.3 0.0025 17.6 0.0 2.1 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 ORX66859.1 - 0.001 19.2 0.0 0.0027 17.9 0.0 1.7 1 0 0 1 1 1 1 U-box domain SF3a60_bindingd PF12108.8 ORX66859.1 - 0.17 11.8 3.2 5.4 7.0 0.0 3.1 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain YL1 PF05764.13 ORX66860.1 - 2.8e-27 96.4 33.0 3.3e-27 96.2 33.0 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 ORX66860.1 - 1.9e-10 40.3 0.1 3.1e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF3881 PF12997.7 ORX66860.1 - 0.23 10.7 3.9 0.42 9.8 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) DUF413 PF04219.12 ORX66860.1 - 2.7 8.1 5.7 4.5 7.4 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF GTP_EFTU PF00009.27 ORX66861.1 - 1.1e-23 83.8 1.0 2.8e-23 82.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ORX66861.1 - 2e-12 47.3 3.9 4.2e-09 36.7 0.1 3.5 3 0 0 3 3 3 2 Elongation factor Tu domain 2 IF-2 PF11987.8 ORX66861.1 - 3.9e-07 30.1 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 ORX66861.1 - 9.2e-07 28.7 0.0 2.9e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 ORX66861.1 - 0.002 18.2 0.1 0.011 15.8 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ORX66861.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ArfGap PF01412.18 ORX66862.1 - 1.2e-35 122.1 0.0 1.3e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CRAL_TRIO PF00650.20 ORX66863.1 - 5.3e-19 68.5 0.0 9e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX66863.1 - 0.00041 20.5 0.0 0.00099 19.3 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF647 PF04884.14 ORX66864.1 - 2e-35 122.6 0.2 1e-34 120.2 0.2 1.9 1 1 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF5614 PF18474.1 ORX66864.1 - 0.069 12.5 0.0 0.16 11.2 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5614) zf-C3HC4_3 PF13920.6 ORX66865.1 - 1.4e-08 34.4 3.9 1.4e-08 34.4 3.9 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX66865.1 - 2.6e-08 33.6 6.3 2.6e-08 33.6 6.3 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX66865.1 - 2.9e-07 30.7 6.0 2.9e-07 30.7 6.0 2.8 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX66865.1 - 7.2e-07 29.1 9.1 2.3e-06 27.5 3.5 3.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX66865.1 - 4.4e-06 26.4 7.9 4.4e-06 26.4 7.9 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX66865.1 - 1.5e-05 24.9 5.1 1.5e-05 24.9 5.1 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-MIZ PF02891.20 ORX66865.1 - 0.0013 18.5 5.5 0.0032 17.2 5.5 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-rbx1 PF12678.7 ORX66865.1 - 0.0089 16.3 3.4 0.026 14.8 3.4 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ORX66865.1 - 0.034 14.3 11.3 0.023 14.8 8.5 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ORX66865.1 - 0.081 12.7 5.7 0.68 9.7 4.0 2.8 2 0 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 ORX66865.1 - 0.13 12.3 2.5 0.32 11.1 2.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Endomucin PF07010.12 ORX66865.1 - 0.2 11.6 2.6 1.4 8.8 0.3 2.4 2 0 0 2 2 2 0 Endomucin IBR PF01485.21 ORX66865.1 - 6.9 7.0 7.2 7 7.0 0.4 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Prok-RING_4 PF14447.6 ORX66865.1 - 8.4 6.3 15.4 0.07 13.0 4.5 2.7 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 D123 PF07065.14 ORX66866.1 - 1.6e-85 287.0 0.0 1.9e-85 286.8 0.0 1.0 1 0 0 1 1 1 1 D123 Interfer-bind PF09294.10 ORX66866.1 - 0.21 11.9 0.0 0.48 10.8 0.0 1.5 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III TFIIF_beta_N PF17683.1 ORX66867.1 - 3.9e-27 95.6 0.4 2.1e-26 93.2 0.3 2.1 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 ORX66867.1 - 3.5e-25 87.9 0.0 6.6e-25 87.0 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 ORX66867.1 - 0.001 19.9 0.2 0.0018 19.1 0.2 1.6 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain ECH_1 PF00378.20 ORX66868.1 - 1e-24 87.3 0.2 1.2e-24 87.0 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX66868.1 - 6e-11 42.4 0.2 7.2e-11 42.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase FGase PF05013.12 ORX66868.1 - 0.03 14.5 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase WD40 PF00400.32 ORX66869.1 - 5.9e-06 26.9 2.1 0.00074 20.3 0.0 4.5 4 1 0 4 4 4 1 WD domain, G-beta repeat DUF2415 PF10313.9 ORX66869.1 - 6.4e-05 22.8 0.2 0.00035 20.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) Cytochrom_D1 PF02239.16 ORX66869.1 - 0.0093 14.5 0.0 0.013 14.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ORX66869.1 - 0.035 13.1 0.1 0.1 11.5 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX66869.1 - 0.073 12.9 0.0 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Sin3a_C PF16879.5 ORX66870.1 - 9.4e-70 235.6 4.6 1.6e-68 231.5 4.8 2.8 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 ORX66870.1 - 4.6e-37 125.9 5.1 4.8e-17 61.8 2.9 3.9 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ORX66870.1 - 3.4e-34 116.8 1.2 2.1e-33 114.3 0.1 2.7 2 0 0 2 2 2 1 Sin3 family co-repressor Terminase_4 PF05119.12 ORX66870.1 - 0.082 13.4 1.0 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 Phage terminase, small subunit Myb_DNA-bind_7 PF15963.5 ORX66870.1 - 0.11 12.4 0.4 0.42 10.5 0.4 2.0 1 1 0 1 1 1 0 Myb DNA-binding like EnY2 PF10163.9 ORX66870.1 - 0.14 12.5 1.6 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Transcription factor e(y)2 W2 PF02020.18 ORX66871.1 - 3.1e-05 24.0 0.1 3.1e-05 24.0 0.1 2.8 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Nop25 PF09805.9 ORX66871.1 - 0.47 10.9 0.0 0.47 10.9 0.0 3.8 3 1 0 3 3 3 0 Nucleolar protein 12 (25kDa) MFS_1 PF07690.16 ORX66872.1 - 2.9e-16 59.3 14.1 2.9e-16 59.3 14.1 2.4 2 1 1 3 3 3 1 Major Facilitator Superfamily zf_C2H2_6 PF18450.1 ORX66872.1 - 0.046 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Zinc Finger domain Shisa PF13908.6 ORX66872.1 - 0.07 13.4 1.2 0.44 10.8 0.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ribosomal_L38e PF01781.18 ORX66873.1 - 3.6e-31 107.1 3.1 3.9e-31 107.0 3.1 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family RNase_PH PF01138.21 ORX66874.1 - 9.1e-15 55.3 0.0 3.5e-14 53.4 0.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX66874.1 - 4.2e-09 36.3 0.0 7.2e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 ERO1 PF04137.15 ORX66875.1 - 6.7e-106 354.5 0.0 8e-106 354.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) SOBP PF15279.6 ORX66876.1 - 0.17 12.4 19.3 0.2 12.2 19.3 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Pkinase PF00069.25 ORX66877.1 - 1.1e-54 185.6 0.0 1.3e-54 185.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX66877.1 - 1.2e-22 80.4 0.0 1.5e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX66877.1 - 6.3e-07 29.0 0.0 8.3e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX66877.1 - 0.072 13.0 0.3 1.3 8.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RhoGEF PF00621.20 ORX66878.1 - 1.3e-40 139.6 0.5 1.7e-40 139.2 0.5 1.1 1 0 0 1 1 1 1 RhoGEF domain DUF4338 PF14236.6 ORX66878.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4338) Cyclin_C_2 PF16899.5 ORX66881.1 - 4e-22 78.6 1.4 1.8e-16 60.4 0.2 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 ORX66881.1 - 8e-13 48.2 0.4 4.8e-11 42.5 0.1 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 ORX66881.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Transcription factor TFIIB repeat UCH PF00443.29 ORX66882.1 - 7.4e-42 143.6 0.4 9.3e-42 143.3 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66882.1 - 2.3e-13 50.5 3.4 2.7e-05 23.9 3.8 2.7 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pex2_Pex12 PF04757.14 ORX66883.1 - 9.2e-27 94.1 0.3 1.3e-26 93.6 0.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 ORX66883.1 - 3e-09 36.6 10.5 4.6e-09 36.0 10.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX66883.1 - 1.6e-07 31.6 16.6 2.5e-07 30.9 16.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ORX66883.1 - 3e-05 23.8 14.3 4.8e-05 23.2 14.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX66883.1 - 7.7e-05 22.5 15.6 0.00012 21.8 15.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX66883.1 - 0.00012 21.8 12.9 0.0002 21.2 12.9 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PTPRCAP PF15713.5 ORX66883.1 - 0.00029 21.1 8.0 0.00054 20.3 8.0 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated zf-RING_5 PF14634.6 ORX66883.1 - 0.0079 16.1 12.9 0.013 15.4 12.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ORX66883.1 - 0.022 15.0 13.0 0.043 14.1 13.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX66883.1 - 0.023 14.7 9.2 0.023 14.7 9.2 1.9 1 1 1 2 2 2 0 RING-type zinc-finger SDA1 PF05285.12 ORX66883.1 - 0.085 12.3 10.1 0.11 11.9 10.1 1.1 1 0 0 1 1 1 0 SDA1 DARPP-32 PF05395.12 ORX66883.1 - 0.15 12.3 9.3 0.24 11.6 9.3 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 zf-C3HC4_4 PF15227.6 ORX66883.1 - 0.73 10.0 13.8 1.5 9.1 13.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CDC45 PF02724.14 ORX66883.1 - 1.2 7.3 8.5 1.9 6.7 8.5 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ORX66883.1 - 1.4 8.2 12.7 2.2 7.5 12.7 1.3 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ORX66883.1 - 1.8 6.7 13.5 2.3 6.3 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 ORX66883.1 - 2 7.5 5.1 3.5 6.8 5.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pes-10 PF07149.11 ORX66883.1 - 5.8 5.9 13.1 8 5.4 13.1 1.1 1 0 0 1 1 1 0 Pes-10 NUFIP1 PF10453.9 ORX66884.1 - 1.3e-09 37.8 3.9 1.3e-09 37.8 3.9 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf_CCCH_4 PF18345.1 ORX66884.1 - 6.4e-07 29.2 4.8 9.9e-07 28.6 4.8 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ORX66884.1 - 4.1e-06 26.5 2.6 6.5e-06 25.9 2.6 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 ORX66884.1 - 0.00032 21.1 5.2 0.00058 20.2 5.2 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ORX66884.1 - 0.00035 20.3 3.7 0.00051 19.8 3.7 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 ORX66884.1 - 0.00095 19.8 0.4 0.0017 19.0 0.4 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_3 PF15663.5 ORX66884.1 - 0.033 14.4 0.2 0.063 13.5 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger containing family ANAPC_CDC26 PF10471.9 ORX66884.1 - 2.4 9.1 5.8 1.1 10.1 2.1 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 UCH PF00443.29 ORX66885.1 - 2.5e-21 76.3 0.0 4.7e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66885.1 - 0.0016 18.1 0.0 0.048 13.2 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX66885.1 - 0.043 14.0 0.0 0.09 12.9 0.0 1.4 1 0 0 1 1 1 0 MATH domain ABC_tran PF00005.27 ORX66886.1 - 6.2e-21 75.4 0.0 1.3e-13 51.6 0.0 3.0 2 2 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX66886.1 - 2.3e-06 27.5 16.2 0.0031 17.2 4.2 3.0 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX66886.1 - 3.3e-06 26.7 0.0 0.083 12.3 0.0 2.6 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX66886.1 - 0.0061 17.0 0.0 0.022 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 ORX66886.1 - 0.017 15.2 0.1 0.031 14.4 0.1 1.4 1 0 0 1 1 1 0 Dynamin family AAA_29 PF13555.6 ORX66886.1 - 0.044 13.5 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX66886.1 - 0.052 13.6 0.1 0.17 12.0 0.1 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX66886.1 - 0.058 13.2 0.1 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system UCH PF00443.29 ORX66887.1 - 2.5e-16 60.0 0.1 3.3e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66887.1 - 0.057 13.0 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase DUF4253 PF14062.6 ORX66887.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) BPL_LplA_LipB PF03099.19 ORX66888.1 - 1.2e-05 25.3 0.0 6.4e-05 22.9 0.0 2.0 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Bud13 PF09736.9 ORX66889.1 - 1.7e-25 90.1 20.6 7.2e-19 68.6 2.4 2.8 2 1 1 3 3 3 2 Pre-mRNA-splicing factor of RES complex Tmemb_14 PF03647.13 ORX66890.1 - 3e-18 66.4 11.8 3.3e-18 66.2 11.8 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C 7TM-7TMR_HD PF07698.11 ORX66890.1 - 0.032 14.0 6.8 0.036 13.8 6.8 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase ATPase_gene1 PF09527.10 ORX66890.1 - 0.033 14.4 7.0 0.41 10.9 5.0 2.3 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DUF2964 PF11177.8 ORX66890.1 - 1.3 9.3 7.7 1.2 9.3 5.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2964) MS_channel PF00924.18 ORX66890.1 - 2.1 7.9 5.0 2.8 7.4 5.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel Spermine_synth PF01564.17 ORX66892.1 - 3.6e-69 232.0 0.0 9.7e-69 230.6 0.0 1.7 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 ORX66892.1 - 1.2e-21 76.4 0.1 2.6e-21 75.3 0.1 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 ORX66892.1 - 0.00011 22.8 0.0 0.00022 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX66892.1 - 0.0017 19.1 0.0 0.004 17.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX66892.1 - 0.028 14.3 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 ORX66892.1 - 0.046 13.0 0.1 0.1 11.8 0.1 1.6 1 1 0 1 1 1 0 O-methyltransferase domain Glyco_tranf_2_5 PF13712.6 ORX66892.1 - 0.075 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family F-box-like PF12937.7 ORX66893.1 - 0.006 16.5 0.2 0.016 15.1 0.2 1.8 1 0 0 1 1 1 1 F-box-like Gcd10p PF04189.13 ORX66894.1 - 3.8e-64 216.7 0.0 6.2e-64 216.0 0.0 1.3 1 0 0 1 1 1 1 Gcd10p family NAD_binding_10 PF13460.6 ORX66895.1 - 9.1e-06 25.7 0.1 2.5e-05 24.2 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ORX66895.1 - 0.0015 17.6 0.0 0.0039 16.2 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX66895.1 - 0.0035 16.8 0.4 0.025 14.1 0.4 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ORX66895.1 - 0.006 15.8 0.1 0.76 8.9 0.0 2.7 1 1 1 2 2 2 2 Male sterility protein GHMP_kinases_N PF00288.26 ORX66896.1 - 1e-11 44.9 3.1 3.2e-11 43.3 3.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX66896.1 - 1.5e-08 34.9 0.0 5.6e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal MAP65_ASE1 PF03999.12 ORX66896.1 - 0.2 10.3 0.1 0.63 8.7 0.1 1.6 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) RNA_pol_A_bac PF01000.26 ORX66897.1 - 3.7e-28 98.1 0.0 7.3e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ORX66897.1 - 7.1e-12 44.6 0.0 1.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Atx10homo_assoc PF09759.9 ORX66898.1 - 1.7e-20 72.9 0.6 2.6e-19 69.1 0.3 3.0 2 1 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain HIRAN PF08797.11 ORX66899.1 - 1.3e-14 53.9 0.0 1.9e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 HIRAN domain MerE PF05052.12 ORX66899.1 - 0.046 13.7 0.7 0.15 12.0 0.2 2.0 1 1 1 2 2 2 0 MerE protein Methyltrn_RNA_4 PF09936.9 ORX66899.1 - 0.069 13.0 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase F-box-like PF12937.7 ORX66900.1 - 0.0066 16.3 0.7 0.042 13.7 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box-like PF12937.7 ORX66902.1 - 7.4e-05 22.6 0.0 0.00024 20.9 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX66902.1 - 0.093 12.6 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 F-box domain DUF5551 PF17705.1 ORX66903.1 - 0.049 13.3 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5551) Bromodomain PF00439.25 ORX66907.1 - 3.4e-18 65.5 0.4 3.6e-18 65.4 0.4 1.0 1 0 0 1 1 1 1 Bromodomain AAA PF00004.29 ORX66911.1 - 4e-26 92.0 0.0 8.7e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ORX66911.1 - 2.4e-12 46.6 0.1 4.4e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ORX66911.1 - 3.3e-10 39.6 0.5 6.2e-10 38.7 0.5 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_OB_N PF17758.1 ORX66911.1 - 0.00035 20.2 0.1 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_2 PF07724.14 ORX66911.1 - 0.0079 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF1128 PF06569.11 ORX66911.1 - 0.13 12.2 0.0 0.51 10.4 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Tim17 PF02466.19 ORX66912.1 - 1.9e-27 95.8 6.1 2.2e-27 95.6 6.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family F-box-like PF12937.7 ORX66914.1 - 6.8e-06 25.9 0.0 2.3e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX66914.1 - 0.024 14.5 0.1 0.19 11.7 0.1 2.3 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ORX66916.1 - 0.021 14.7 0.5 0.15 12.0 0.1 2.3 2 0 0 2 2 2 0 F-box-like HIRAN PF08797.11 ORX66917.1 - 8.5e-15 54.5 0.0 1.1e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 HIRAN domain MerE PF05052.12 ORX66917.1 - 0.065 13.2 0.9 0.2 11.6 0.3 2.0 1 1 1 2 2 2 0 MerE protein Wbp11 PF09429.10 ORX66918.1 - 2.1e-16 60.1 15.1 2.1e-16 60.1 15.1 2.5 2 0 0 2 2 2 1 WW domain binding protein 11 DUF4865 PF16157.5 ORX66918.1 - 0.015 15.3 0.9 0.03 14.3 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4865) ALAD PF00490.21 ORX66918.1 - 0.09 11.9 1.2 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 Delta-aminolevulinic acid dehydratase TRIQK PF15168.6 ORX66918.1 - 0.22 11.5 5.0 0.32 10.9 4.3 1.7 1 1 0 1 1 1 0 Triple QxxK/R motif-containing protein family Nop25 PF09805.9 ORX66918.1 - 4.3 7.8 16.0 0.44 11.0 11.3 1.8 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) USP7_ICP0_bdg PF12436.8 ORX66919.1 - 1.5e-33 116.1 0.0 2.1e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 ORX66919.1 - 8.6e-24 84.4 0.0 1.8e-23 83.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66919.1 - 3.2e-09 36.8 0.0 1.4e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ORX66920.1 - 2.2e-31 107.4 20.5 1.8e-07 31.8 0.3 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX66920.1 - 6.2e-16 58.5 5.7 0.0056 16.9 0.4 5.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX66920.1 - 1.5e-07 30.4 4.3 0.18 10.4 0.1 4.3 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX66920.1 - 0.00027 20.0 2.9 0.31 10.0 0.1 3.9 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX66920.1 - 0.00062 19.2 0.0 0.47 9.7 0.0 3.1 3 0 0 3 3 3 2 WD40-like domain XPG_N PF00752.17 ORX66921.1 - 6.6e-25 87.5 0.0 4.7e-24 84.8 0.0 2.4 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 ORX66921.1 - 2.3e-21 76.0 0.0 9.5e-21 74.0 0.0 2.2 1 0 0 1 1 1 1 XPG I-region DUF1690 PF07956.11 ORX66921.1 - 9.2 6.7 13.3 0.59 10.5 3.8 3.4 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) AAA PF00004.29 ORX66923.1 - 2.7e-29 102.3 0.3 1.2e-21 77.5 0.0 4.1 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX66923.1 - 1.1e-18 66.8 5.8 7e-12 45.0 1.0 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX66923.1 - 1.6e-09 38.4 2.9 0.0005 20.5 0.2 3.8 3 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 ORX66923.1 - 1e-05 25.7 0.0 0.039 14.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX66923.1 - 1.5e-05 25.3 0.0 0.18 12.1 0.0 3.3 4 0 0 4 4 3 2 AAA domain AAA_7 PF12775.7 ORX66923.1 - 5.7e-05 22.7 0.1 0.28 10.7 0.0 2.2 2 0 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 ORX66923.1 - 6.3e-05 23.0 0.0 0.099 12.5 0.0 2.2 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea TIP49 PF06068.13 ORX66923.1 - 0.00014 21.2 0.0 0.00038 19.8 0.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain NB-ARC PF00931.22 ORX66923.1 - 0.00016 21.0 0.0 0.058 12.6 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ABC_tran PF00005.27 ORX66923.1 - 0.00025 21.6 0.0 0.11 13.1 0.0 2.4 2 0 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.18 ORX66923.1 - 0.00035 20.4 0.1 0.091 12.5 0.1 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AFG1_ATPase PF03969.16 ORX66923.1 - 0.00045 19.2 0.0 0.081 11.8 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase TsaE PF02367.17 ORX66923.1 - 0.00081 19.4 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ORX66923.1 - 0.00098 19.5 0.1 0.65 10.4 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 ORX66923.1 - 0.0011 18.7 2.1 0.0095 15.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 ORX66923.1 - 0.0052 16.0 0.0 0.66 9.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ORX66923.1 - 0.0057 16.4 0.0 3.3 7.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ORX66923.1 - 0.0058 16.4 0.0 0.64 9.7 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 ORX66923.1 - 0.0078 15.5 0.0 1.3 8.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 ORX66923.1 - 0.0089 16.0 2.4 4.6 7.1 0.1 3.1 2 1 1 3 3 3 0 NACHT domain AAA_18 PF13238.6 ORX66923.1 - 0.009 16.6 0.2 1.4 9.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain PhoH PF02562.16 ORX66923.1 - 0.011 15.2 0.6 0.65 9.4 0.0 2.6 2 1 0 2 2 2 0 PhoH-like protein RsgA_GTPase PF03193.16 ORX66923.1 - 0.013 15.4 0.3 4.1 7.3 0.1 3.4 2 1 1 3 3 3 0 RsgA GTPase AAA_5 PF07728.14 ORX66923.1 - 0.013 15.5 0.0 0.75 9.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.15 ORX66923.1 - 0.02 13.7 0.1 0.2 10.4 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein Rad17 PF03215.15 ORX66923.1 - 0.02 14.8 0.1 7.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain T2SSE PF00437.20 ORX66923.1 - 0.024 13.7 0.1 2.4 7.1 0.1 2.7 2 1 0 2 2 2 0 Type II/IV secretion system protein RuvB_N PF05496.12 ORX66923.1 - 0.028 14.2 0.0 0.41 10.4 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 ORX66923.1 - 0.03 14.7 0.7 0.85 9.9 0.0 2.5 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 ORX66923.1 - 0.036 13.8 0.1 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.29 ORX66923.1 - 0.038 13.8 0.7 1.5 8.6 0.0 2.7 2 1 0 3 3 3 0 DEAD/DEAH box helicase ResIII PF04851.15 ORX66923.1 - 0.041 13.9 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ORX66923.1 - 0.047 12.9 0.1 0.58 9.3 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TniB PF05621.11 ORX66923.1 - 0.068 12.6 0.0 13 5.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 ORX66923.1 - 0.073 12.6 0.2 0.67 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 ORX66923.1 - 0.079 12.5 0.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_24 PF13479.6 ORX66923.1 - 0.095 12.4 1.2 29 4.3 0.1 3.3 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX66923.1 - 0.2 11.0 1.7 2.7 7.3 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family IPT PF01745.16 ORX66923.1 - 0.24 10.7 2.6 0.91 8.9 0.1 2.7 2 1 0 2 2 2 0 Isopentenyl transferase ABC_tran PF00005.27 ORX66924.1 - 9.2e-05 23.0 0.3 0.0002 21.9 0.1 1.6 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ORX66924.1 - 0.00035 20.1 0.4 0.00041 19.9 0.4 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain FKBP_N_2 PF18023.1 ORX66924.1 - 0.026 14.6 0.1 0.039 14.0 0.1 1.3 1 0 0 1 1 1 0 BDBT FKBP like N-terminal UCH PF00443.29 ORX66925.1 - 6.9e-15 55.2 0.0 1.1e-14 54.5 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX66925.1 - 0.059 13.0 3.3 1.1 8.8 0.3 2.3 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Rdx PF10262.9 ORX66927.1 - 1.6e-32 111.5 0.0 1.9e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Rdx family PH PF00169.29 ORX66928.1 - 0.0025 18.3 0.1 0.0078 16.7 0.1 1.9 1 0 0 1 1 1 1 PH domain PT PF04886.12 ORX66928.1 - 0.094 12.3 12.0 0.011 15.2 4.7 2.5 2 0 0 2 2 2 0 PT repeat SH3_1 PF00018.28 ORX66929.1 - 4e-10 39.1 0.0 4e-10 39.1 0.0 1.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ORX66929.1 - 0.00012 21.9 0.1 0.00024 20.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX66929.1 - 0.00012 21.7 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 ORX66929.1 - 0.0033 17.5 0.0 0.0059 16.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 ORX66929.1 - 0.0046 17.2 0.6 0.008 16.4 0.6 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_16 PF18348.1 ORX66929.1 - 0.021 14.6 0.1 0.054 13.3 0.1 1.7 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Lon_C PF05362.13 ORX66931.1 - 1.6e-60 204.1 0.0 4.7e-60 202.6 0.0 1.7 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ORX66931.1 - 4.8e-30 105.0 0.2 9.5e-30 104.0 0.2 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ORX66931.1 - 5.3e-18 65.7 0.0 1.3e-17 64.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 ORX66931.1 - 3.5e-07 30.1 0.0 8.4e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ORX66931.1 - 3.5e-07 30.3 0.0 7.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 ORX66931.1 - 2e-05 23.7 0.0 5.8e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 ORX66931.1 - 5.9e-05 22.9 0.0 0.00046 20.0 0.0 2.4 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX66931.1 - 0.00054 20.2 0.1 0.011 16.1 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX66931.1 - 0.0014 19.0 0.3 0.0056 17.1 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain ClpB_D2-small PF10431.9 ORX66931.1 - 0.0022 18.0 0.3 0.0022 18.0 0.3 2.4 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_2 PF07724.14 ORX66931.1 - 0.0023 18.1 0.0 0.0067 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ORX66931.1 - 0.0095 16.5 2.7 0.044 14.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain SKI PF01202.22 ORX66931.1 - 0.024 14.8 0.1 0.082 13.0 0.0 2.0 2 0 0 2 2 1 0 Shikimate kinase AAA_14 PF13173.6 ORX66931.1 - 0.03 14.4 0.0 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ORX66931.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 ORX66931.1 - 0.052 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 ORX66931.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX66931.1 - 0.064 13.0 0.1 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX66931.1 - 0.092 12.9 0.0 0.5 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ORX66931.1 - 0.095 12.6 0.8 5.4 6.9 0.1 3.1 2 1 1 3 3 3 0 NTPase AAA_3 PF07726.11 ORX66931.1 - 0.14 12.0 0.0 0.72 9.7 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ORX66931.1 - 1.5 9.3 0.0 1.5 9.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain Ribosomal_60s PF00428.19 ORX66931.1 - 5.8 7.6 21.0 6.8 7.4 12.4 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Peptidase_S28 PF05577.12 ORX66932.1 - 9.6e-79 265.2 0.1 1.2e-78 264.9 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 ORX66932.1 - 0.05 13.1 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family BRF1 PF07741.13 ORX66933.1 - 3.5e-23 81.8 7.3 3.5e-23 81.8 7.3 2.0 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TFIIB PF00382.19 ORX66933.1 - 3e-18 65.6 0.3 1.4e-17 63.5 0.1 2.1 2 0 0 2 2 2 1 Transcription factor TFIIB repeat LRIF1 PF15741.5 ORX66933.1 - 0.3 9.6 1.6 0.36 9.3 1.6 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Ribosomal_L14 PF00238.19 ORX66934.1 - 1.2e-45 154.6 1.7 1.3e-45 154.4 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e RsgI_N PF12791.7 ORX66934.1 - 0.044 13.7 0.0 0.098 12.6 0.0 1.6 1 0 0 1 1 1 0 Anti-sigma factor N-terminus Metallophos PF00149.28 ORX66935.1 - 5.7e-33 115.1 0.4 7.6e-33 114.7 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DnaJ PF00226.31 ORX66936.1 - 9.4e-18 64.1 0.3 3.3e-17 62.4 0.3 2.0 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 ORX66936.1 - 5.1e-13 49.0 1.9 3.1e-07 30.5 0.0 3.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX66936.1 - 1.9e-05 24.8 1.1 0.31 11.3 0.1 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain DivIC PF04977.15 ORX66936.1 - 0.046 13.5 0.2 0.046 13.5 0.2 3.0 2 0 0 2 2 2 0 Septum formation initiator DUF262 PF03235.14 ORX66936.1 - 0.86 9.7 7.5 5.4 7.1 6.6 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF262 FUSC PF04632.12 ORX66936.1 - 2.6 6.4 6.1 6 5.3 6.1 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family S4 PF01479.25 ORX66937.1 - 1.1e-14 53.9 0.1 1.9e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ORX66937.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 S4 domain Ub-Mut7C PF14451.6 ORX66937.1 - 0.045 13.6 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 Mut7-C ubiquitin Pirin_C_2 PF17954.1 ORX66937.1 - 0.2 11.9 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain AMP-binding PF00501.28 ORX66938.1 - 6e-77 259.0 0.0 7.6e-77 258.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX66938.1 - 0.00016 22.5 0.0 0.00073 20.5 0.0 2.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 ORX66939.1 - 4.9e-124 414.2 0.0 2.1e-65 221.0 0.0 2.6 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ORX66939.1 - 2.2e-10 41.3 0.0 0.00067 20.6 0.0 3.0 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain Ribosomal_L34e PF01199.18 ORX66940.1 - 2.5e-44 149.5 3.8 3.2e-44 149.2 3.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Zn_ribbon_recom PF13408.6 ORX66940.1 - 0.09 13.3 0.3 0.09 13.3 0.3 1.8 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Yip1 PF04893.17 ORX66941.1 - 9.7e-10 38.4 17.3 1.5e-09 37.8 17.2 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 ORX66941.1 - 0.01 15.6 14.2 0.012 15.3 12.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) YIF1 PF03878.15 ORX66941.1 - 0.013 15.1 5.9 0.018 14.6 3.3 2.1 1 1 0 2 2 2 0 YIF1 DUF373 PF04123.13 ORX66941.1 - 0.54 9.6 5.4 0.56 9.6 0.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF373) ATP-synt_8 PF00895.20 ORX66941.1 - 2.8 8.5 5.7 3.8 8.0 0.2 2.4 2 0 0 2 2 2 0 ATP synthase protein 8 Pkinase PF00069.25 ORX66942.1 - 6.8e-36 124.0 0.0 2.4e-25 89.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 ORX66942.1 - 9.1e-34 116.4 0.0 1.4e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 ORX66942.1 - 1.1e-19 70.8 0.0 7.3e-17 61.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ORX66942.1 - 0.013 14.9 0.3 0.025 13.9 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ORX66942.1 - 0.045 12.7 0.0 0.059 12.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 ORX66942.1 - 0.052 12.3 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ORX66942.1 - 0.062 13.2 0.3 0.062 13.2 0.3 2.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Mem_trans PF03547.18 ORX66943.1 - 5.7e-26 90.8 6.1 5.1e-13 48.2 0.1 2.0 2 0 0 2 2 2 2 Membrane transport protein DUF3343 PF11823.8 ORX66943.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) EF-hand_7 PF13499.6 ORX66944.1 - 6.2e-28 97.1 1.5 1.4e-16 60.7 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX66944.1 - 8.8e-26 87.5 3.9 9.5e-09 34.2 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ORX66944.1 - 1.6e-23 80.5 1.3 2.3e-08 33.3 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ORX66944.1 - 5.3e-17 60.5 3.5 4.6e-08 32.2 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ORX66944.1 - 4e-15 55.4 7.8 2.7e-11 43.2 1.0 3.5 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX66944.1 - 2.1e-06 28.0 0.0 0.0002 21.6 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ORX66944.1 - 3.5e-06 26.9 1.0 6e-05 23.0 0.2 2.5 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ORX66944.1 - 0.00047 20.4 0.0 0.33 11.3 0.0 2.3 2 1 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 ORX66944.1 - 0.00054 20.1 0.3 0.021 15.0 0.1 2.2 1 1 1 2 2 2 2 Dockerin type I domain Caleosin PF05042.13 ORX66944.1 - 0.083 12.8 0.1 3.9 7.4 0.0 2.7 1 1 2 3 3 3 0 Caleosin related protein DUF2666 PF10869.8 ORX66944.1 - 0.12 12.6 0.3 7.3 6.8 0.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2666) Mem_trans PF03547.18 ORX66945.1 - 2.9e-25 88.5 4.8 2.3e-23 82.2 4.8 2.0 1 1 0 1 1 1 1 Membrane transport protein DUF2569 PF10754.9 ORX66945.1 - 6.8 7.1 11.8 5.1 7.5 0.1 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2569) Mem_trans PF03547.18 ORX66946.1 - 4.2e-26 91.2 6.0 6e-24 84.2 6.0 2.1 1 1 0 1 1 1 1 Membrane transport protein DUF2407_C PF13373.6 ORX66947.1 - 9.4e-21 74.5 5.7 4.9e-20 72.1 5.7 2.0 1 1 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 ORX66947.1 - 4.5e-13 49.6 0.0 9.1e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 ORX66947.1 - 2.6e-10 39.9 0.0 5.4e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 ORX66947.1 - 7.3e-08 32.5 0.0 2e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 ORX66947.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TRAP-gamma PF07074.12 ORX66947.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Mito_carr PF00153.27 ORX66948.1 - 1.9e-44 149.5 8.1 4e-16 58.7 0.6 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein GDPD PF03009.17 ORX66949.1 - 2.6e-35 122.4 0.0 4e-34 118.5 0.0 2.2 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 ORX66949.1 - 3.1e-07 30.9 0.1 0.0013 19.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX66949.1 - 5.7e-06 26.3 4.0 0.076 13.6 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ORX66949.1 - 0.00061 20.1 0.6 4.7 7.8 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ORX66949.1 - 0.23 12.1 3.2 1.4 9.6 0.0 3.7 4 1 2 6 6 6 0 Ankyrin repeats (many copies) ATP-synt PF00231.19 ORX66950.1 - 1.6e-71 241.3 8.1 1.8e-71 241.1 8.1 1.0 1 0 0 1 1 1 1 ATP synthase OPA3 PF07047.12 ORX66951.1 - 3.7e-43 146.3 0.3 5.3e-43 145.8 0.3 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) ZapB PF06005.12 ORX66951.1 - 0.001 19.4 2.4 0.001 19.4 2.4 2.2 1 1 1 2 2 2 1 Cell division protein ZapB TMF_TATA_bd PF12325.8 ORX66951.1 - 0.0045 17.2 2.2 0.0087 16.3 2.2 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 ORX66951.1 - 0.0055 17.2 3.7 0.0089 16.6 3.7 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF4164 PF13747.6 ORX66951.1 - 0.014 15.6 3.9 0.029 14.7 3.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) ADIP PF11559.8 ORX66951.1 - 0.016 15.3 1.7 0.027 14.6 1.7 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4085 PF13315.6 ORX66951.1 - 0.055 13.1 0.1 0.081 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) DivIC PF04977.15 ORX66951.1 - 0.12 12.2 3.0 0.44 10.3 2.7 2.1 1 1 0 1 1 1 0 Septum formation initiator SYCE1 PF15233.6 ORX66951.1 - 0.26 11.4 5.0 0.32 11.0 2.0 2.4 1 1 2 3 3 3 0 Synaptonemal complex central element protein 1 PigN PF04987.14 ORX66952.1 - 2e-105 353.3 20.8 2e-105 353.3 20.8 1.8 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 ORX66952.1 - 2.2e-09 37.4 0.1 3.3e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX66952.1 - 1.3e-06 28.1 0.1 1.9e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Sulfatase DHHC PF01529.20 ORX66953.1 - 1.6e-36 125.3 5.9 1.6e-36 125.3 5.9 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Med22 PF06179.12 ORX66954.1 - 4.1e-17 62.3 0.2 6.3e-17 61.7 0.2 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Ytp1 PF10355.9 ORX66955.1 - 2.8e-32 112.0 11.3 2e-16 60.0 1.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ORX66955.1 - 9.6e-28 96.0 4.9 2.7e-27 94.6 0.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 ORX66955.1 - 0.0012 19.0 6.1 0.0012 19.0 6.1 3.5 3 1 0 3 3 3 1 Eukaryotic cytochrome b561 Polysacc_deac_1 PF01522.21 ORX66955.1 - 0.18 11.7 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide deacetylase Tetraspanin PF00335.20 ORX66955.1 - 2 8.0 7.8 14 5.3 0.1 2.9 2 1 1 3 3 3 0 Tetraspanin family EI24 PF07264.11 ORX66957.1 - 2 8.6 14.5 2.7 8.2 14.5 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Srg PF02118.21 ORX66957.1 - 7.5 6.1 20.5 10 5.7 20.5 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor Man-6-P_recep PF02157.15 ORX66958.1 - 5e-11 42.2 0.1 2.1e-07 30.3 0.2 2.1 2 0 0 2 2 2 2 Mannose-6-phosphate receptor CIMR PF00878.18 ORX66958.1 - 1.5e-08 34.9 0.0 2.6e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 ORX66958.1 - 1.8e-08 34.6 0.0 2.6e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 SIR2 PF02146.17 ORX66959.1 - 1.7e-53 181.1 0.0 2.1e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Sir2 family YdjO PF14169.6 ORX66959.1 - 0.026 14.2 0.4 0.05 13.3 0.4 1.4 1 0 0 1 1 1 0 Cold-inducible protein YdjO zf-C2H2 PF00096.26 ORX66960.1 - 3.7e-11 42.8 13.2 8.8e-06 25.9 4.8 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX66960.1 - 6.5e-10 39.0 20.6 9.2e-07 29.0 0.9 3.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX66960.1 - 3.3e-08 33.7 11.3 0.00026 21.6 3.5 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX66960.1 - 0.0036 17.6 1.3 0.0036 17.6 1.3 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX66960.1 - 0.0054 17.0 1.3 0.0054 17.0 1.3 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX66960.1 - 0.012 15.6 2.9 0.012 15.6 2.9 2.6 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX66960.1 - 0.014 15.7 4.9 0.12 12.6 0.2 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-BED PF02892.15 ORX66960.1 - 0.045 13.8 1.5 0.045 13.8 1.5 2.1 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_11 PF16622.5 ORX66960.1 - 0.05 13.4 6.4 0.084 12.6 0.6 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type FOXP-CC PF16159.5 ORX66960.1 - 0.052 14.2 1.0 0.44 11.2 0.1 2.1 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 ORX66960.1 - 0.087 13.2 6.0 0.42 11.0 1.2 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF4519 PF15012.6 ORX66960.1 - 0.2 11.8 1.5 0.33 11.2 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Golgin_A5 PF09787.9 ORX66961.1 - 0.013 15.0 3.9 0.02 14.4 3.9 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 YscO-like PF16789.5 ORX66961.1 - 0.027 14.5 2.5 0.027 14.5 2.5 1.7 2 0 0 2 2 2 0 YscO-like protein APG6_N PF17675.1 ORX66961.1 - 0.033 14.7 1.5 0.061 13.8 1.5 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 ORX66961.1 - 0.049 12.9 7.3 0.087 12.1 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LCIB_C_CA PF18599.1 ORX66961.1 - 0.11 11.7 0.3 0.21 10.9 0.3 1.4 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases bZIP_2 PF07716.15 ORX66961.1 - 0.12 12.5 2.3 0.3 11.2 2.3 1.7 1 1 0 1 1 1 0 Basic region leucine zipper Jnk-SapK_ap_N PF09744.9 ORX66961.1 - 0.28 11.4 5.0 0.47 10.7 5.0 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlgT_N PF16548.5 ORX66961.1 - 0.76 10.4 4.9 1.7 9.3 4.9 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain DUF148 PF02520.17 ORX66961.1 - 3.8 7.7 7.1 8.3 6.6 6.7 1.7 1 1 1 2 2 2 0 Domain of unknown function DUF148 BST2 PF16716.5 ORX66961.1 - 7.7 7.2 7.3 0.73 10.5 2.1 1.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 NPR3 PF03666.13 ORX66962.1 - 1.3e-37 129.7 0.4 1.2e-36 126.5 0.0 2.6 2 1 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Ctr PF04145.15 ORX66963.1 - 0.0011 19.5 4.4 0.0011 19.5 4.4 2.0 1 1 1 2 2 2 1 Ctr copper transporter family Hexapep PF00132.24 ORX66963.1 - 0.11 12.3 0.2 1.6 8.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) Ctr PF04145.15 ORX66964.1 - 2.6e-05 24.9 8.5 0.0029 18.3 4.3 2.3 1 1 1 2 2 2 2 Ctr copper transporter family RRM_1 PF00076.22 ORX66965.1 - 1.5e-18 66.3 0.0 7e-17 61.0 0.0 2.0 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_polyA_pol_N PF12630.7 ORX66965.1 - 0.022 15.1 0.0 0.34 11.3 0.0 2.0 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain DHHC PF01529.20 ORX66966.1 - 4.9e-16 59.0 11.6 4.9e-16 59.0 11.6 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase EF_TS PF00889.19 ORX66967.1 - 5.7e-27 94.7 0.0 3.5e-23 82.3 0.0 2.3 1 1 1 2 2 2 2 Elongation factor TS UBA PF00627.31 ORX66967.1 - 0.043 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Formyl_trans_N PF00551.19 ORX66968.1 - 7.1e-52 175.8 0.0 8.2e-52 175.6 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase DTW PF03942.15 ORX66969.1 - 1.7e-31 109.5 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 DTW domain C1_2 PF03107.16 ORX66969.1 - 0.11 12.8 2.5 0.22 11.9 2.5 1.4 1 0 0 1 1 1 0 C1 domain TPR_1 PF00515.28 ORX66971.1 - 1.5e-18 65.7 4.2 0.00057 19.6 0.3 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX66971.1 - 5.2e-15 54.9 4.7 4.4e-05 23.1 0.3 4.6 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.17 ORX66971.1 - 1e-12 47.1 7.4 0.005 16.9 0.5 5.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ORX66971.1 - 1.6e-12 46.9 4.9 0.014 15.7 0.1 5.2 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ORX66971.1 - 1.6e-11 44.0 6.0 0.0061 17.3 0.0 5.7 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX66971.1 - 3.3e-11 42.5 0.9 0.0057 16.8 0.2 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 ORX66971.1 - 5e-09 36.4 9.1 0.00047 20.4 0.2 5.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX66971.1 - 6.4e-09 36.3 3.5 0.0015 19.2 0.0 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX66971.1 - 3e-06 27.3 3.9 0.0038 17.3 1.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX66971.1 - 3.2e-06 27.6 10.1 0.089 13.3 0.1 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX66971.1 - 2.6e-05 24.4 7.1 1.2 9.5 2.3 4.0 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX66971.1 - 0.00018 21.3 2.5 0.62 10.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX66971.1 - 0.012 16.1 2.8 20 6.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1641 PF07849.11 ORX66971.1 - 0.032 14.1 0.1 0.065 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Fis1_TPR_C PF14853.6 ORX66971.1 - 0.092 12.8 0.5 2.8 8.1 0.1 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ORX66971.1 - 0.42 10.9 4.1 3.6 7.9 0.2 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 His_Phos_2 PF00328.22 ORX66972.1 - 1.5e-05 24.6 0.0 2.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PLDc_2 PF13091.6 ORX66973.1 - 3.3e-28 98.2 0.3 5.8e-28 97.4 0.3 1.4 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 ORX66973.1 - 2e-06 27.5 2.3 0.00043 19.9 2.3 2.4 1 1 0 1 1 1 1 FAM83 A-H HA2 PF04408.23 ORX66974.1 - 4.5e-29 100.9 0.0 1.1e-28 99.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ORX66974.1 - 1e-07 32.3 0.1 2.9e-07 30.8 0.1 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ORX66974.1 - 4.8e-05 23.6 0.2 0.0002 21.7 0.2 2.1 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold UvrD-helicase PF00580.21 ORX67015.1 - 8.1e-50 170.1 0.5 7.8e-24 84.8 0.0 2.2 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ORX67015.1 - 5.2e-41 141.2 0.0 1e-39 136.9 0.0 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ORX67015.1 - 8.3e-27 94.3 0.0 1.8e-26 93.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ORX67015.1 - 1.1e-10 41.1 0.1 0.00012 21.9 0.0 2.8 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ORX67015.1 - 2.6e-08 33.8 0.3 0.00015 21.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ORX67015.1 - 8e-06 25.8 0.2 0.31 10.7 0.0 4.2 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 ORX67015.1 - 0.011 15.3 0.0 1.2 8.7 0.0 3.3 3 1 0 3 3 3 0 AAA domain PhoH PF02562.16 ORX67015.1 - 0.021 14.3 1.0 0.23 10.9 0.2 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 ORX67015.1 - 0.14 12.2 0.1 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Cyclin_N PF00134.23 ORX67017.1 - 0.06 13.1 0.0 0.075 12.8 0.0 1.1 1 0 0 1 1 1 0 Cyclin, N-terminal domain cwf18 PF08315.12 ORX67018.1 - 9.6e-16 58.7 5.6 1e-15 58.6 5.6 1.0 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Sbi-IV PF11621.8 ORX67018.1 - 0.035 14.5 0.6 0.047 14.0 0.6 1.4 1 1 0 1 1 1 0 C3 binding domain 4 of IgG-bind protein SBI Hexokinase_2 PF03727.16 ORX67019.1 - 2.7e-73 246.4 0.0 3.5e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX67019.1 - 1.2e-35 123.2 0.2 4.5e-22 78.9 0.0 2.3 1 1 1 2 2 2 2 Hexokinase VPS13_mid_rpt PF16910.5 ORX67021.1 - 2.4e-70 236.6 0.3 2.4e-70 236.6 0.3 2.9 4 0 0 4 4 4 1 Repeating coiled region of VPS13 VPS13 PF16908.5 ORX67021.1 - 3.9e-66 223.2 0.1 2.6e-65 220.5 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 ORX67021.1 - 1.1e-65 220.8 7.6 1.9e-61 207.0 0.8 3.0 2 1 1 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ORX67021.1 - 2.9e-61 207.2 0.0 1.6e-60 204.8 0.0 2.2 2 1 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 ORX67021.1 - 3.2e-38 130.4 0.1 7.3e-38 129.3 0.1 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 ORX67021.1 - 2.3e-11 43.9 0.0 1.2e-10 41.6 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Apt1 PF10351.9 ORX67021.1 - 0.0011 18.0 0.2 0.054 12.3 0.0 2.8 3 0 0 3 3 3 1 Golgi-body localisation protein domain DUF3040 PF11239.8 ORX67021.1 - 0.0036 17.5 0.1 0.019 15.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3040) Nucleopor_Nup85 PF07575.13 ORX67022.1 - 2e-37 129.0 0.0 1.7e-35 122.7 0.0 2.0 1 1 1 2 2 2 2 Nup85 Nucleoporin DUF3701 PF12482.8 ORX67022.1 - 0.18 11.9 1.8 15 5.7 0.1 2.9 2 1 0 2 2 2 0 Phage integrase protein Skp1 PF01466.19 ORX67023.1 - 3.2e-21 75.2 0.1 4.8e-21 74.6 0.1 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ORX67023.1 - 3.8e-20 71.8 0.0 5.8e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain MatE PF01554.18 ORX67024.1 - 1.8e-42 144.7 33.7 5.9e-26 91.1 9.2 3.2 3 1 0 3 3 3 2 MatE GFA PF04828.14 ORX67025.1 - 2.5e-09 37.3 0.9 2.5e-09 37.3 0.9 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme ABC2_membrane PF01061.24 ORX67026.1 - 2.7e-28 98.8 26.1 4.4e-28 98.2 26.1 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ORX67026.1 - 5.1e-28 98.3 0.0 1.1e-27 97.3 0.0 1.5 2 0 0 2 2 1 1 ABC transporter RsgA_GTPase PF03193.16 ORX67026.1 - 0.001 19.0 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ORX67026.1 - 0.0029 17.2 0.7 0.027 14.0 0.7 2.2 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ORX67026.1 - 0.0071 16.2 0.5 0.77 9.5 0.4 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX67026.1 - 0.027 14.8 0.0 0.046 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX67026.1 - 0.079 13.1 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ORX67026.1 - 0.11 12.2 0.6 0.34 10.6 0.6 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX67026.1 - 0.12 12.3 0.3 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 NACHT domain Cytidylate_kin PF02224.18 ORX67026.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_29 PF13555.6 ORX67026.1 - 0.15 11.8 0.2 0.4 10.5 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 ORX67026.1 - 0.17 12.1 0.1 0.56 10.5 0.1 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 ORX67026.1 - 0.28 10.7 0.5 0.52 9.9 0.5 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AF-4 PF05110.13 ORX67026.1 - 1.4 7.0 3.0 1.8 6.6 3.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TruB_N PF01509.18 ORX67027.1 - 2.4e-22 79.9 0.0 3.6e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ORX67027.1 - 9.2e-09 35.3 0.3 1.8e-08 34.4 0.3 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Cellulase PF00150.18 ORX67028.1 - 4.8e-07 29.5 6.9 6.7e-07 29.0 6.9 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ER PF01133.17 ORX67028.1 - 0.0035 17.3 0.1 0.75 9.9 0.0 2.3 2 0 0 2 2 2 2 Enhancer of rudimentary Abhydrolase_3 PF07859.13 ORX67029.1 - 7.4e-33 114.2 0.0 1e-32 113.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX67029.1 - 3.5e-10 39.3 0.0 6.4e-10 38.4 0.0 1.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 ORX67029.1 - 0.0019 17.5 0.0 0.0041 16.4 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 ORX67029.1 - 0.015 15.2 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2974 PF11187.8 ORX67029.1 - 0.19 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Phage_lysozyme PF00959.19 ORX67030.1 - 2.2e-07 31.3 0.0 3.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX67030.1 - 0.00032 20.9 0.1 0.00095 19.4 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain CHAP PF05257.16 ORX67031.1 - 1.2e-09 38.6 4.1 1.2e-09 38.6 4.1 2.3 2 1 1 3 3 3 1 CHAP domain Trypan_PARP PF05887.11 ORX67031.1 - 0.014 15.4 1.2 0.024 14.6 1.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) EGF PF00008.27 ORX67031.1 - 0.077 13.3 3.1 0.17 12.2 3.1 1.6 1 0 0 1 1 1 0 EGF-like domain TonB_N PF16031.5 ORX67031.1 - 0.31 11.6 12.0 0.65 10.5 12.0 1.5 1 0 0 1 1 1 0 TonB polyproline region UCH PF00443.29 ORX67034.1 - 3.3e-21 76.0 0.0 4.8e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX67034.1 - 2.6e-05 24.0 0.0 0.05 13.2 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX67034.1 - 0.00026 21.1 0.4 0.0018 18.4 0.1 2.2 2 0 0 2 2 2 1 MATH domain Sugar_tr PF00083.24 ORX67035.1 - 2.1e-88 297.2 26.9 2.4e-88 297.0 26.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX67035.1 - 4.3e-24 85.1 31.0 4.3e-24 85.1 31.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.29 ORX67036.1 - 2.5e-49 167.4 0.8 9.7e-49 165.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX67036.1 - 5e-24 84.8 3.3 3.6e-23 82.0 0.0 3.4 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Prefoldin_2 PF01920.20 ORX67037.1 - 7.9e-20 70.8 13.1 1e-19 70.4 13.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit DcrB PF08786.11 ORX67037.1 - 0.0043 17.1 1.3 0.0056 16.8 0.9 1.5 1 1 0 1 1 1 1 DcrB DUF2584 PF10763.9 ORX67037.1 - 0.059 13.5 0.5 0.17 12.1 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2584) Spc24 PF08286.11 ORX67037.1 - 0.9 9.8 9.6 7.8 6.8 0.2 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF641 PF04859.12 ORX67037.1 - 1.3 9.4 12.6 0.31 11.4 0.9 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) G-patch PF01585.23 ORX67038.1 - 4.5e-17 61.7 3.2 1.4e-16 60.1 3.2 1.9 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 ORX67038.1 - 4.2e-08 33.1 0.0 5.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 R3H domain G-patch_2 PF12656.7 ORX67038.1 - 5.6e-08 32.8 3.2 5.6e-08 32.8 3.2 2.0 1 1 1 2 2 2 1 G-patch domain Diphthami_syn_2 PF01902.17 ORX67043.1 - 1.1e-10 41.4 0.0 1.8e-08 34.2 0.0 2.3 1 1 0 1 1 1 1 Diphthamide synthase DUF2621 PF11084.8 ORX67043.1 - 0.061 13.3 0.0 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) WD40 PF00400.32 ORX67044.1 - 1.7e-29 101.4 6.5 1.5e-06 28.8 0.2 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ORX67044.1 - 1.2e-06 27.4 2.4 0.66 8.6 0.1 4.6 3 2 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ORX67044.1 - 0.00041 20.6 0.0 2.3 8.6 0.0 3.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX67044.1 - 0.012 15.0 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Hexokinase_2 PF03727.16 ORX67045.1 - 1.7e-32 112.8 1.0 2.1e-19 69.9 0.0 2.1 1 1 1 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 ORX67045.1 - 0.01 15.7 0.1 0.022 14.6 0.0 1.6 2 0 0 2 2 2 0 Hexokinase AGH PF17558.2 ORX67045.1 - 0.066 13.4 0.0 0.099 12.8 0.0 1.3 1 0 0 1 1 1 0 Androgenic gland hormone Hexokinase_2 PF03727.16 ORX67046.1 - 3.6e-45 154.3 0.1 4.6e-45 153.9 0.1 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX67046.1 - 1.4e-15 57.7 0.0 2.3e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Hexokinase ROK PF00480.20 ORX67046.1 - 0.15 11.5 1.7 0.18 11.2 0.3 1.7 2 0 0 2 2 2 0 ROK family UNC45-central PF11701.8 ORX67047.1 - 2.4e-05 24.4 0.0 0.003 17.5 0.0 2.7 2 1 0 2 2 2 1 Myosin-binding striated muscle assembly central Arm PF00514.23 ORX67047.1 - 4e-05 23.5 0.8 1.3 9.2 0.0 4.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat T2SSF PF00482.23 ORX67047.1 - 0.14 12.1 1.6 0.44 10.5 0.0 2.7 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F tRNA-synt_2 PF00152.20 ORX67048.1 - 3.1e-80 269.6 0.1 4.1e-80 269.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX67048.1 - 0.003 17.5 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain AUX_IAA PF02309.16 ORX67048.1 - 0.03 14.2 0.0 0.094 12.6 0.0 1.7 2 0 0 2 2 2 0 AUX/IAA family Mago_nashi PF02792.14 ORX67051.1 - 4.3e-31 108.0 0.2 5.5e-31 107.6 0.2 1.1 1 0 0 1 1 1 1 Mago nashi protein TRAPP PF04051.16 ORX67052.1 - 1.4e-37 128.7 0.0 1.7e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Acyltransferase PF01553.21 ORX67053.1 - 2.8e-11 43.2 0.0 3.3e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase CMD PF02627.20 ORX67054.1 - 0.0032 17.5 0.5 0.043 13.9 0.1 2.5 2 1 1 3 3 3 1 Carboxymuconolactone decarboxylase family CMD PF02627.20 ORX67055.1 - 5.8e-05 23.1 0.1 0.00026 21.0 0.0 2.0 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Abhydrolase_3 PF07859.13 ORX67056.1 - 1.9e-39 135.7 0.0 3e-39 135.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX67056.1 - 2.7e-12 46.2 0.0 4.6e-12 45.5 0.0 1.4 1 1 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 ORX67056.1 - 0.0083 15.0 0.0 0.15 10.9 0.0 2.1 2 0 0 2 2 2 1 Carboxylesterase family ACP_syn_III_C PF08541.10 ORX67056.1 - 0.028 14.6 0.0 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Hydrolase_4 PF12146.8 ORX67056.1 - 0.083 12.1 0.0 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Oxysterol_BP PF01237.18 ORX67057.1 - 1.4e-64 218.3 3.5 1.4e-62 211.7 3.5 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein CRM1_C PF08767.11 ORX67059.1 - 0.0018 17.5 0.3 0.005 16.1 0.3 1.7 1 0 0 1 1 1 1 CRM1 C terminal DUF366 PF04017.12 ORX67059.1 - 0.083 12.4 1.1 0.19 11.2 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF366) p450 PF00067.22 ORX67060.1 - 2.6e-65 221.0 0.0 3.4e-65 220.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4504 PF14953.6 ORX67061.1 - 3.8e-05 23.2 0.1 6.7e-05 22.4 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4504) SBDS_C PF09377.10 ORX67062.1 - 4.6e-39 133.0 1.9 4.6e-39 133.0 1.9 1.5 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 ORX67062.1 - 9.5e-34 115.4 2.7 1.7e-33 114.5 2.7 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Isy1 PF06246.12 ORX67063.1 - 2.6e-81 272.9 4.7 2.8e-81 272.8 4.7 1.0 1 0 0 1 1 1 1 Isy1-like splicing family ubiquitin PF00240.23 ORX67064.1 - 0.021 14.6 0.0 0.061 13.1 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin family DUF2407 PF10302.9 ORX67064.1 - 0.021 15.4 0.0 0.043 14.4 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain AtpR PF12966.7 ORX67064.1 - 0.28 11.7 2.5 0.52 10.8 2.5 1.4 1 0 0 1 1 1 0 N-ATPase, AtpR subunit ECH_1 PF00378.20 ORX67065.1 - 3.9e-46 157.4 0.2 5e-45 153.8 0.2 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX67065.1 - 2.2e-29 103.0 0.1 2.3e-28 99.7 0.1 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX67066.1 - 1.6e-44 152.1 0.6 6.2e-44 150.2 0.6 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX67066.1 - 1.1e-29 104.0 0.3 1.8e-28 100.0 0.3 2.2 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Hexokinase_2 PF03727.16 ORX67067.1 - 1.5e-78 263.5 0.0 2.9e-78 262.6 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 ORX67067.1 - 5e-66 222.4 0.0 6.9e-66 221.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Nop25 PF09805.9 ORX67068.1 - 6.3e-19 68.8 28.5 6.3e-19 68.8 28.5 2.3 1 1 1 2 2 2 1 Nucleolar protein 12 (25kDa) Nup188_C PF18378.1 ORX67068.1 - 8.2 5.1 6.0 1.8 7.3 2.9 1.4 2 0 0 2 2 2 0 Nuclear pore protein NUP188 C-terminal domain NmrA PF05368.13 ORX67069.1 - 3.5e-09 36.6 0.0 3.5e-09 36.6 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX67069.1 - 0.0069 16.3 0.0 0.0069 16.3 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding RRM_1 PF00076.22 ORX67070.1 - 1e-10 41.3 0.0 1.5e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 ORX67070.1 - 7.3e-09 36.3 0.1 1.3e-08 35.5 0.1 1.4 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 ORX67070.1 - 3.6e-06 26.8 3.7 3.6e-06 26.8 3.7 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 ORX67070.1 - 0.00026 20.8 2.3 0.00026 20.8 2.3 2.4 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ORX67070.1 - 0.0003 21.0 0.4 0.001 19.2 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 ORX67070.1 - 0.00074 19.3 3.4 0.002 17.9 3.4 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_occluded PF16842.5 ORX67070.1 - 0.0019 18.0 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ORX67070.1 - 0.0034 17.4 0.0 0.0069 16.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif FYVE PF01363.21 ORX67070.1 - 0.054 13.6 1.9 0.067 13.3 0.5 1.9 2 0 0 2 2 2 0 FYVE zinc finger zf-CCCH_2 PF14608.6 ORX67070.1 - 0.66 10.5 6.8 0.13 12.8 2.4 2.2 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger OrsD PF12013.8 ORX67071.1 - 1.3e-06 28.8 2.0 1.3e-06 28.8 2.0 3.5 3 1 0 3 3 3 1 Orsellinic acid/F9775 biosynthesis cluster protein D YycH PF07435.11 ORX67071.1 - 0.017 14.1 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 YycH protein OrsD PF12013.8 ORX67072.1 - 0.0013 19.2 4.2 0.0065 16.9 4.2 2.3 1 1 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 ORX67072.1 - 3.8 7.1 4.7 0.72 9.5 0.1 2.0 2 0 0 2 2 2 0 Zinc-finger C2H2-type MFS_1 PF07690.16 ORX67073.1 - 1.2e-21 77.1 53.6 4.5e-18 65.3 40.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glycos_transf_1 PF00534.20 ORX67074.1 - 3.9e-31 107.9 0.0 1.7e-30 105.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX67074.1 - 9.2e-18 65.0 0.0 5.8e-17 62.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX67074.1 - 1.1e-14 54.8 0.1 1.8e-14 54.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX67074.1 - 1e-07 32.5 0.7 1.7e-07 31.8 0.2 1.6 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ORX67074.1 - 4.2e-05 23.8 0.0 0.0001 22.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Epimerase_2 PF02350.19 ORX67074.1 - 0.12 11.2 0.1 0.26 10.1 0.0 1.6 2 0 0 2 2 2 0 UDP-N-acetylglucosamine 2-epimerase ISG65-75 PF11727.8 ORX67074.1 - 0.25 10.6 0.0 0.35 10.1 0.0 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Arm PF00514.23 ORX67075.1 - 1.9e-31 107.1 26.3 3.8e-07 29.9 0.0 11.5 12 1 0 12 12 12 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX67075.1 - 1.3e-11 44.7 7.2 0.0074 16.6 0.2 7.1 5 2 4 9 9 9 3 HEAT repeats HEAT PF02985.22 ORX67075.1 - 4.3e-11 42.1 16.6 0.071 13.4 0.2 8.2 8 0 0 8 8 8 4 HEAT repeat HEAT_EZ PF13513.6 ORX67075.1 - 9.1e-06 26.1 19.5 3 8.4 1.0 8.5 7 2 2 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 ORX67075.1 - 1.1e-05 25.6 8.6 0.00069 19.7 2.9 3.9 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.9 ORX67075.1 - 4.1e-05 23.5 1.0 1.5 8.9 0.0 5.4 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 ORX67075.1 - 0.00047 19.7 3.0 0.37 10.2 0.0 4.4 2 2 2 4 4 4 1 Armadillo-like Vac14_Fab1_bd PF12755.7 ORX67075.1 - 0.0005 20.6 0.1 0.73 10.5 0.0 4.0 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region V-ATPase_H_C PF11698.8 ORX67075.1 - 0.0046 17.1 2.7 0.87 9.7 0.2 4.0 3 1 0 4 4 4 1 V-ATPase subunit H DUF3109 PF11307.8 ORX67075.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) Fungal_trans_2 PF11951.8 ORX67075.1 - 0.013 14.3 0.0 0.028 13.2 0.0 1.6 1 0 0 1 1 1 0 Fungal specific transcription factor domain GTP_EFTU PF00009.27 ORX67076.1 - 1.6e-63 213.8 0.0 3.3e-63 212.8 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX67076.1 - 5.4e-36 123.0 0.0 1.5e-35 121.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ORX67076.1 - 3.7e-30 103.8 0.0 1e-29 102.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ORX67076.1 - 1.7e-26 92.1 0.1 4.2e-26 90.8 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX67076.1 - 2e-12 47.3 0.1 4.6e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ORX67076.1 - 2.3e-06 27.5 0.0 6.3e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ORX67076.1 - 0.00072 19.6 0.1 0.0018 18.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF442 PF04273.13 ORX67076.1 - 0.053 13.6 0.0 6 7.0 0.0 3.0 3 0 0 3 3 3 0 Putative phosphatase (DUF442) AvrPtoB_bdg PF16847.5 ORX67076.1 - 0.059 13.8 0.0 0.9 10.1 0.0 2.5 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain AIG1 PF04548.16 ORX67076.1 - 0.077 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family DUF4118 PF13493.6 ORX67077.1 - 0.074 12.8 1.7 0.27 11.0 1.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) NAP PF00956.18 ORX67078.1 - 7.7e-29 100.7 11.2 1.1e-25 90.3 5.4 2.5 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Ribosomal_L16 PF00252.18 ORX67079.1 - 9.6e-44 148.6 0.1 1.7e-43 147.8 0.1 1.3 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e Nkap_C PF06047.11 ORX67081.1 - 2.8e-45 152.6 2.5 3.4e-45 152.3 2.5 1.1 1 0 0 1 1 1 1 NF-kappa-B-activating protein C-terminal domain GrpE PF01025.19 ORX67082.1 - 2.2e-48 164.1 1.2 2.7e-48 163.8 1.2 1.1 1 0 0 1 1 1 1 GrpE Clusterin PF01093.17 ORX67082.1 - 0.013 14.6 0.1 0.015 14.4 0.1 1.1 1 0 0 1 1 1 0 Clusterin DUF4201 PF13870.6 ORX67082.1 - 0.022 14.5 5.9 0.028 14.2 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) PRP38 PF03371.15 ORX67082.1 - 0.033 14.1 0.7 0.048 13.5 0.7 1.2 1 0 0 1 1 1 0 PRP38 family PKcGMP_CC PF16808.5 ORX67082.1 - 0.055 13.3 1.6 0.1 12.4 1.6 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mit_KHE1 PF10173.9 ORX67082.1 - 0.22 11.6 1.3 0.36 10.9 1.3 1.5 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related SWI-SNF_Ssr4 PF08549.10 ORX67082.1 - 0.7 8.5 4.9 0.85 8.2 4.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Proteasome PF00227.26 ORX67083.1 - 3.1e-60 202.9 0.0 3.7e-60 202.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX67083.1 - 1.5e-08 34.1 0.0 5.9e-08 32.2 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature UCH PF00443.29 ORX67084.1 - 1.2e-31 110.2 0.0 1.8e-31 109.6 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX67084.1 - 1.7e-08 34.4 0.0 3.7e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BRE1 PF08647.11 ORX67084.1 - 0.039 14.0 0.7 0.078 13.1 0.7 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase LPP PF04728.13 ORX67084.1 - 5.2 7.5 5.7 8.7 6.8 0.5 3.2 2 1 1 3 3 3 0 Lipoprotein leucine-zipper tRNA-synt_2d PF01409.20 ORX67085.1 - 2e-44 151.9 0.4 1.9e-24 86.5 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ORX67085.1 - 4.5e-22 78.3 0.0 1.2e-20 73.7 0.0 2.9 4 0 0 4 4 4 1 Ferredoxin-fold anticodon binding domain Cyclin_N PF00134.23 ORX67086.1 - 1.4e-12 47.4 0.0 4.2e-11 42.7 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 ORX67086.1 - 0.012 15.6 0.0 4.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Transcription factor TFIIB repeat E1-E2_ATPase PF00122.20 ORX67088.1 - 8.7e-40 136.2 1.5 8.7e-40 136.2 1.5 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX67088.1 - 2.1e-32 112.3 16.2 3.7e-20 72.4 0.6 3.5 2 1 1 3 3 3 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX67088.1 - 8.3e-21 73.9 0.0 1.8e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX67088.1 - 1.8e-16 61.1 0.1 3.2e-16 60.3 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX67088.1 - 2.8e-06 27.9 0.1 7.4e-06 26.5 0.1 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX67088.1 - 1.5e-05 24.5 0.0 4.4e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX67088.1 - 9.7e-05 22.2 1.2 0.00014 21.7 0.4 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase FliMN_C PF01052.20 ORX67088.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term Serpentine_r_xa PF03383.15 ORX67088.1 - 0.83 9.6 4.9 0.16 11.9 0.1 2.2 3 0 0 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa UPF0004 PF00919.20 ORX67089.1 - 4.5e-30 103.6 0.1 9.9e-30 102.5 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 ORX67089.1 - 1.2e-24 87.6 0.1 3.2e-24 86.2 0.1 1.8 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 ORX67089.1 - 0.00041 20.3 0.0 0.00076 19.4 0.0 1.5 1 0 0 1 1 1 1 TRAM domain LEA_3 PF03242.13 ORX67089.1 - 0.62 10.8 3.1 0.64 10.8 1.1 2.0 2 0 0 2 2 2 0 Late embryogenesis abundant protein RFC1 PF08519.12 ORX67090.1 - 8.1e-55 185.3 0.1 4e-53 179.8 0.0 2.5 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 ORX67090.1 - 6.3e-19 68.1 0.0 3e-17 62.8 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 ORX67090.1 - 3.4e-11 43.4 0.0 9.1e-11 42.0 0.0 1.7 1 1 1 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 ORX67090.1 - 1.3e-10 41.8 0.0 4.1e-10 40.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT_2 PF16589.5 ORX67090.1 - 4.3e-07 30.2 0.0 2.5e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain AAA_22 PF13401.6 ORX67090.1 - 2.4e-06 27.8 0.0 6e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX67090.1 - 2.2e-05 24.9 0.0 5.9e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PTCB-BRCT PF12738.7 ORX67090.1 - 5.6e-05 23.0 0.0 0.00018 21.3 0.0 1.9 2 0 0 2 2 2 1 twin BRCT domain DNA_pol3_delta PF06144.13 ORX67090.1 - 9.5e-05 22.2 0.0 0.00024 21.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 ORX67090.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ORX67090.1 - 0.0012 18.6 0.0 0.0037 17.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX67090.1 - 0.0022 18.0 0.0 0.015 15.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 ORX67090.1 - 0.0037 17.2 0.7 0.071 13.0 0.7 2.4 1 1 0 1 1 1 1 NTPase AAA_18 PF13238.6 ORX67090.1 - 0.0047 17.5 0.0 0.012 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX67090.1 - 0.01 15.3 0.0 0.054 13.0 0.0 2.0 1 1 1 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ORX67090.1 - 0.036 14.4 0.1 1 9.7 0.0 3.1 2 1 0 2 2 2 0 RNA helicase AAA_assoc_2 PF16193.5 ORX67090.1 - 0.045 14.1 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain NACHT PF05729.12 ORX67090.1 - 0.056 13.4 0.0 0.69 9.8 0.0 2.3 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ORX67090.1 - 0.075 12.7 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX67090.1 - 0.085 12.9 0.0 0.38 10.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_8 PF12780.7 ORX67090.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 Zeta_toxin PF06414.12 ORX67090.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 ORX67090.1 - 0.12 12.8 0.2 1.3 9.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain Spt5_N PF11942.8 ORX67090.1 - 0.38 11.8 7.8 0.33 12.0 4.1 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal YL1 PF05764.13 ORX67090.1 - 0.4 10.7 7.9 1 9.4 7.9 1.7 1 0 0 1 1 1 0 YL1 nuclear protein UBA2_C PF16195.5 ORX67090.1 - 0.82 10.4 13.4 0.16 12.7 8.7 2.3 2 0 0 2 2 1 0 SUMO-activating enzyme subunit 2 C-terminus Zip PF02535.22 ORX67091.1 - 0.024 13.8 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EphA2_TM PF14575.6 ORX67091.1 - 0.029 15.2 0.0 0.2 12.6 0.0 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Troponin-I_N PF11636.8 ORX67091.1 - 0.087 12.8 0.2 0.087 12.8 0.2 2.4 2 0 0 2 2 2 0 Troponin I residues 1-32 zf-CCCH_2 PF14608.6 ORX67091.1 - 0.25 11.9 8.1 1.1 9.8 3.6 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 ORX67091.1 - 1.1 9.4 4.5 14 5.9 0.1 2.4 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 ORX67092.1 - 2.2e-10 40.2 19.1 2.6e-05 24.0 6.2 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ORX67092.1 - 8.9e-05 22.7 3.8 0.016 15.4 0.7 2.2 2 0 0 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 ORX67092.1 - 9.7e-05 22.3 16.4 0.00029 20.8 2.3 2.4 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 ORX67092.1 - 0.00038 21.1 4.8 0.3 11.8 0.5 2.3 2 0 0 2 2 2 2 Torus domain PDDEXK_2 PF12784.7 ORX67092.1 - 0.024 14.2 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase Bromodomain PF00439.25 ORX67093.1 - 5.8e-20 71.2 0.0 6.3e-20 71.0 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Rgp1 PF08737.10 ORX67096.1 - 7.3e-50 170.4 0.0 2.2e-49 168.8 0.0 1.7 1 1 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 ORX67096.1 - 0.00013 22.1 0.0 0.003 17.6 0.0 2.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX67096.1 - 0.00087 19.7 0.0 0.44 11.0 0.0 3.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain DUF2039 PF10217.9 ORX67097.1 - 9.9e-30 102.7 14.0 1.4e-29 102.3 14.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 ORX67097.1 - 0.043 14.4 17.0 0.27 11.8 17.0 2.2 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT zinc-ribbons_6 PF07191.12 ORX67097.1 - 0.087 12.8 8.9 0.14 12.2 8.9 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-RING_5 PF14634.6 ORX67097.1 - 1.1 9.3 9.5 0.46 10.5 2.2 2.5 2 0 0 2 2 2 0 zinc-RING finger domain Brix PF04427.18 ORX67098.1 - 4.6e-33 114.9 0.1 6.4e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 Brix domain DUF1068 PF06364.12 ORX67098.1 - 0.87 9.4 2.7 1.3 8.8 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) EMC3_TMCO1 PF01956.16 ORX67099.1 - 1.6e-23 83.3 0.0 1.9e-23 83.0 0.0 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Atg14 PF10186.9 ORX67099.1 - 0.043 12.9 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Orf78 PF06024.12 ORX67099.1 - 0.67 10.3 3.8 6 7.2 0.3 2.2 1 1 1 2 2 2 0 Orf78 (ac78) Zn_clus PF00172.18 ORX67100.1 - 1e-05 25.6 10.4 1.9e-05 24.6 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ORX67100.1 - 0.048 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 PAS fold RIO1 PF01163.22 ORX67101.1 - 4.4e-51 173.2 0.1 6.5e-51 172.6 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 ORX67101.1 - 2.6e-31 107.6 0.0 8e-31 106.1 0.0 1.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 ORX67101.1 - 8e-11 42.3 0.2 5e-05 23.3 0.0 2.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX67101.1 - 2.8e-08 33.4 0.0 0.0045 16.4 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX67101.1 - 0.012 15.0 0.1 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 Kinase-like TPR_1 PF00515.28 ORX67104.1 - 2.4e-52 172.7 32.3 1.7e-08 33.9 0.3 10.2 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 ORX67104.1 - 9.1e-47 153.4 26.6 1.7e-07 30.8 0.1 10.1 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 ORX67104.1 - 2e-32 108.6 20.8 0.0001 22.2 0.0 9.9 9 1 1 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 ORX67104.1 - 4.8e-25 86.1 9.7 0.00024 21.7 0.1 8.7 4 3 5 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67104.1 - 2.7e-24 85.5 9.4 0.0012 19.4 0.0 6.9 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX67104.1 - 8.6e-22 77.4 16.0 8.5e-06 26.2 0.3 6.9 5 1 3 8 8 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 ORX67104.1 - 2.8e-20 72.4 20.6 4.2e-08 33.4 3.6 7.3 3 2 3 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 ORX67104.1 - 2.9e-20 71.5 13.9 0.004 17.7 0.0 9.0 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 ORX67104.1 - 2.8e-19 68.1 19.6 0.0032 17.7 0.2 10.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX67104.1 - 2.8e-18 65.3 33.4 1.7e-06 27.6 1.3 8.7 5 4 4 9 9 9 6 TPR repeat TPR_7 PF13176.6 ORX67104.1 - 1.9e-14 52.5 22.5 0.059 13.4 0.1 9.1 8 2 2 10 10 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 ORX67104.1 - 2.2e-11 43.7 10.8 0.0029 17.7 0.7 5.8 2 1 5 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX67104.1 - 2e-07 31.1 13.9 2.8e-05 24.2 4.5 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ORX67104.1 - 8.2e-07 28.5 3.4 0.028 13.6 0.2 4.1 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 ORX67104.1 - 4.1e-06 26.7 5.9 1.1 8.9 0.0 4.6 3 2 1 4 4 4 2 Tetratricopeptide repeat-like domain DUF410 PF04190.13 ORX67104.1 - 0.00094 19.0 1.5 0.3 10.8 0.5 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF410) DUF2225 PF09986.9 ORX67104.1 - 0.0016 18.2 2.6 1.2 8.9 0.0 2.9 1 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) SNAP PF14938.6 ORX67104.1 - 0.0019 17.7 7.8 0.044 13.2 1.2 4.0 1 1 2 3 3 3 1 Soluble NSF attachment protein, SNAP TOM20_plant PF06552.12 ORX67104.1 - 0.015 15.1 2.0 0.45 10.2 0.2 3.7 3 2 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF627 PF04781.12 ORX67104.1 - 0.019 15.0 0.1 0.089 12.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF627) Fis1_TPR_C PF14853.6 ORX67104.1 - 0.021 14.9 5.7 42 4.3 0.2 5.2 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat DUF1824 PF08854.10 ORX67104.1 - 0.082 12.8 0.2 0.97 9.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1824) DUF3808 PF10300.9 ORX67104.1 - 0.083 11.6 0.6 7 5.3 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3808) BTAD PF03704.17 ORX67104.1 - 0.16 12.4 2.3 2.5 8.5 0.8 2.6 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 ORX67104.1 - 0.24 11.3 21.5 5.7 7.0 0.1 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat TFIIA PF03153.13 ORX67104.1 - 3 7.7 8.8 4.4 7.2 8.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V-ATPase_G PF03179.15 ORX67105.1 - 2.9e-25 88.8 18.8 3.2e-25 88.7 18.8 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 ORX67105.1 - 0.078 13.1 22.3 0.031 14.4 11.2 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Noelin-1 PF12308.8 ORX67105.1 - 0.092 12.7 3.6 0.13 12.3 3.6 1.3 1 0 0 1 1 1 0 Neurogenesis glycoprotein V-ATPase_G_2 PF16999.5 ORX67105.1 - 0.2 12.1 19.2 0.36 11.3 19.2 1.4 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit TUTF7_u4 PF16631.5 ORX67105.1 - 0.2 12.3 8.2 0.19 12.3 7.5 1.3 1 1 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 Sds3 PF08598.11 ORX67105.1 - 0.53 10.3 10.4 3 7.8 10.4 1.9 1 1 0 1 1 1 0 Sds3-like PEP-utilisers_N PF05524.13 ORX67105.1 - 0.8 9.9 11.7 1.7 8.8 11.6 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal Metal_resist PF13801.6 ORX67105.1 - 0.8 9.9 10.4 1.2 9.4 10.4 1.3 1 0 0 1 1 1 0 Heavy-metal resistance KfrA_N PF11740.8 ORX67105.1 - 1.1 9.9 18.6 2.5 8.8 6.5 2.1 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term CT_C_D PF02682.16 ORX67105.1 - 1.3 8.7 4.1 4.3 7.0 0.4 2.0 1 1 1 2 2 2 0 Carboxyltransferase domain, subdomain C and D Nebulin PF00880.18 ORX67105.1 - 2.3 8.2 6.3 49 4.0 0.3 3.4 3 0 0 3 3 3 0 Nebulin repeat DUF5403 PF17395.2 ORX67105.1 - 3.3 8.1 6.7 2 8.8 4.1 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5403) DUF4407 PF14362.6 ORX67105.1 - 3.4 6.9 12.1 3.9 6.7 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L3 PF00297.22 ORX67106.1 - 3.2e-175 582.5 8.8 3.8e-175 582.2 8.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 GCV_T PF01571.21 ORX67111.1 - 6e-76 255.2 0.2 4.1e-63 213.1 0.0 2.1 1 1 1 2 2 2 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ORX67111.1 - 2.6e-17 62.5 0.0 5.3e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain GSH_synthase PF03199.15 ORX67111.1 - 0.043 14.3 0.0 0.11 12.9 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic glutathione synthase Aldedh PF00171.22 ORX67112.1 - 7.9e-116 387.3 0.3 2.3e-74 250.6 0.0 3.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1107 PF06526.12 ORX67112.1 - 0.0069 16.3 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1107) 17kDa_Anti_2 PF16998.5 ORX67112.1 - 0.3 11.0 1.7 4.7 7.2 0.1 2.2 2 0 0 2 2 2 0 17 kDa outer membrane surface antigen UQ_con PF00179.26 ORX67113.1 - 2.2e-44 150.5 0.0 2.5e-44 150.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 ORX67113.1 - 0.012 15.2 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 ORX67113.1 - 0.22 11.8 1.8 0.44 10.9 1.8 1.6 1 1 0 1 1 1 0 RWD domain Methyltransf_11 PF08241.12 ORX67114.1 - 2.2e-11 44.2 0.1 6.5e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX67114.1 - 2.9e-09 37.5 0.1 1.1e-08 35.6 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX67114.1 - 3.1e-08 33.5 0.0 4.1e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX67114.1 - 6.9e-05 23.5 0.0 0.00014 22.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ORX67114.1 - 0.004 16.8 0.0 0.044 13.4 0.0 2.1 1 1 0 1 1 1 1 Nodulation protein S (NodS) TPMT PF05724.11 ORX67114.1 - 0.0058 16.3 0.0 0.0081 15.8 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) NT-C2 PF10358.9 ORX67115.1 - 2.3e-10 40.4 0.1 3.2e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins HU-CCDC81_bac_1 PF18174.1 ORX67115.1 - 0.12 12.3 0.1 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 Peptidase_C15 PF01470.17 ORX67116.1 - 2.7e-06 27.7 0.0 0.0054 16.9 0.0 2.1 2 0 0 2 2 2 2 Pyroglutamyl peptidase Methyltransf_5 PF01795.19 ORX67117.1 - 5.6e-53 180.5 6.6 1.8e-31 109.8 0.0 4.7 1 1 2 3 3 3 3 MraW methylase family SIMPL PF04402.14 ORX67117.1 - 0.017 15.6 0.1 0.27 11.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF541) zf-RING_2 PF13639.6 ORX67118.1 - 1.3e-12 47.8 7.3 3.6e-12 46.4 7.3 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX67118.1 - 1.6e-09 37.4 6.1 3.3e-09 36.4 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX67118.1 - 2e-09 37.6 9.7 1.9e-08 34.4 9.7 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX67118.1 - 6.6e-09 35.6 3.6 1.4e-08 34.6 3.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX67118.1 - 9.4e-09 35.0 5.1 1.9e-08 34.0 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX67118.1 - 2.9e-06 26.9 1.9 2.9e-06 26.9 1.9 2.0 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 ORX67118.1 - 6.4e-06 25.7 4.2 1.2e-05 24.8 4.2 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 ORX67118.1 - 4.9e-05 23.1 7.4 0.00015 21.6 7.3 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX67118.1 - 0.00014 21.8 6.3 0.00042 20.2 6.4 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX67118.1 - 0.00052 20.0 5.2 0.0089 16.1 5.2 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ORX67118.1 - 0.00089 19.1 5.6 0.0018 18.1 5.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ORX67118.1 - 0.0025 18.0 4.6 0.0048 17.0 4.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 ORX67118.1 - 0.012 15.0 0.5 0.017 14.5 0.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger zf-Nse PF11789.8 ORX67118.1 - 0.02 14.7 2.2 0.038 13.8 2.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 ORX67118.1 - 0.18 12.0 1.9 0.53 10.5 1.9 1.9 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 ORX67118.1 - 0.26 11.1 5.2 0.56 10.0 5.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 ORX67118.1 - 0.41 10.8 5.6 1.1 9.4 5.6 1.8 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 ORX67118.1 - 0.99 9.8 5.3 2 8.8 5.3 1.6 1 0 0 1 1 1 0 RING-like domain Vps39_2 PF10367.9 ORX67118.1 - 1.1 9.8 4.1 0.23 11.9 0.6 1.7 2 0 0 2 2 1 0 Vacuolar sorting protein 39 domain 2 Helicase_C PF00271.31 ORX67119.1 - 2.3e-08 34.3 0.0 6.6e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX67119.1 - 2.9e-06 27.1 0.0 1.6e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Drc1-Sld2 PF11719.8 ORX67119.1 - 0.00014 21.5 8.1 0.0055 16.3 5.0 2.4 2 0 0 2 2 2 2 DNA replication and checkpoint protein tRNA-synt_2b PF00587.25 ORX67120.1 - 3.5e-35 121.6 0.0 6.6e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX67120.1 - 4.3e-23 81.6 6.5 4.3e-23 81.6 6.5 1.7 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 ORX67120.1 - 0.16 12.1 1.3 0.94 9.6 1.0 2.2 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4141 PF13605.6 ORX67120.1 - 0.2 10.9 0.7 0.45 9.8 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) RNA_pol_L PF01193.24 ORX67121.1 - 0.14 11.6 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Peptidase_S8 PF00082.22 ORX67122.1 - 2.9e-40 138.4 1.4 5.3e-40 137.5 1.4 1.4 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX67122.1 - 8e-12 45.0 0.1 1.8e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 PA domain fn3_5 PF06280.12 ORX67122.1 - 4.8e-05 24.0 0.0 0.00012 22.8 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain SH3_9 PF14604.6 ORX67123.1 - 1.2e-11 44.2 0.1 1.8e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX67123.1 - 4.2e-10 39.1 0.0 5.8e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX67123.1 - 0.03 14.0 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain DUF726 PF05277.12 ORX67125.1 - 8.7e-55 186.0 7.5 7.8e-38 130.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF726) Phage_holin_3_6 PF07332.11 ORX67125.1 - 0.21 11.6 4.1 0.57 10.2 4.1 1.7 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Chs7 PF12271.8 ORX67126.1 - 1.9e-66 224.4 7.6 2.1e-66 224.2 7.6 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone SID-1_RNA_chan PF13965.6 ORX67126.1 - 0.08 11.3 0.1 0.08 11.3 0.1 2.0 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 UXS1_N PF11803.8 ORX67126.1 - 0.22 11.9 1.9 2.1 8.8 0.1 2.7 1 1 1 2 2 2 0 UDP-glucuronate decarboxylase N-terminal Vma12 PF11712.8 ORX67126.1 - 1.7 8.7 9.0 1.7 8.7 0.3 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Trp_syntA PF00290.20 ORX67127.1 - 1.4e-92 309.3 0.3 2.5e-92 308.4 0.1 1.5 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 ORX67127.1 - 6.8e-44 150.4 0.8 1.1e-43 149.8 0.8 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.21 ORX67127.1 - 0.084 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein HAD PF12710.7 ORX67128.1 - 8.1e-12 45.9 0.3 1.1e-11 45.6 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ORX67128.1 - 5.8e-06 25.9 0.1 2.5e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 ORX67128.1 - 0.0017 18.7 1.5 0.0082 16.5 1.5 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX67128.1 - 0.0069 16.5 1.7 0.23 11.5 1.7 2.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX67129.1 - 5.1e-12 46.6 0.2 8.6e-12 45.8 0.2 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ORX67129.1 - 3.3e-05 23.4 0.2 0.068 12.5 0.0 2.0 2 0 0 2 2 2 2 Putative Phosphatase Hydrolase PF00702.26 ORX67129.1 - 0.0025 18.1 0.7 0.0057 17.0 0.7 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX67129.1 - 0.0031 17.6 1.4 0.29 11.2 0.1 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Bax1-I PF01027.20 ORX67130.1 - 2.2e-49 168.1 29.1 2.5e-49 167.9 29.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Nup54 PF13874.6 ORX67131.1 - 1.2e-07 32.0 0.3 1.2e-07 32.0 0.3 2.1 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Glyco_hydro_52 PF03512.13 ORX67131.1 - 0.083 11.8 0.1 0.097 11.6 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 DUF2722 PF10846.8 ORX67131.1 - 0.12 11.3 6.3 0.11 11.5 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 ORX67131.1 - 0.18 11.4 9.8 0.17 11.5 9.8 1.2 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 ORX67131.1 - 3 6.6 13.3 2.7 6.7 13.3 1.1 1 0 0 1 1 1 0 Androgen receptor OCRE PF17780.1 ORX67132.1 - 0.00014 21.8 13.0 0.00035 20.5 13.0 1.6 1 0 0 1 1 1 1 OCRE domain Sec16 PF12932.7 ORX67133.1 - 3.4e-11 43.8 0.0 6.4e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_C PF12931.7 ORX67133.1 - 2.4e-07 30.7 0.1 3.7e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 SET PF00856.28 ORX67135.1 - 2.6e-13 50.7 0.0 4.5e-13 49.9 0.0 1.4 1 1 0 1 1 1 1 SET domain PrmA PF06325.13 ORX67136.1 - 1.8e-13 50.6 0.3 2.3e-13 50.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX67136.1 - 2.6e-11 43.4 0.6 2.4e-10 40.2 0.6 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX67136.1 - 5.7e-07 30.2 0.4 1.3e-06 29.0 0.2 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX67136.1 - 7e-07 29.2 0.5 9.7e-07 28.7 0.5 1.3 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX67136.1 - 1.5e-06 28.0 0.0 2.1e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 ORX67136.1 - 1.2e-05 25.0 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 ORX67136.1 - 3.1e-05 24.0 0.1 4.5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ORX67136.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase UPF0020 PF01170.18 ORX67136.1 - 0.0003 20.5 0.3 0.004 16.9 0.3 2.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 ORX67136.1 - 0.00092 19.8 0.0 0.0018 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ORX67136.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 ORX67136.1 - 0.0018 18.2 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.11 ORX67136.1 - 0.0026 17.3 0.7 0.0044 16.6 0.3 1.6 2 0 0 2 2 2 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.6 ORX67136.1 - 0.0031 17.5 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX67136.1 - 0.0071 17.1 0.0 0.013 16.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 ORX67136.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase AviRa PF11599.8 ORX67136.1 - 0.02 14.4 0.1 0.025 14.1 0.1 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_10 PF05971.12 ORX67136.1 - 0.02 14.2 0.0 0.027 13.8 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase CMAS PF02353.20 ORX67136.1 - 0.025 13.9 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ORX67136.1 - 0.028 13.7 0.2 0.071 12.4 0.2 1.6 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family DUF43 PF01861.16 ORX67136.1 - 0.039 13.2 0.1 0.09 12.0 0.1 1.4 1 1 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain tRNA_U5-meth_tr PF05958.11 ORX67136.1 - 0.045 12.7 0.0 0.069 12.1 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase TehB PF03848.14 ORX67136.1 - 0.052 13.0 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB PCMT PF01135.19 ORX67136.1 - 0.078 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DNA_methylase PF00145.17 ORX67136.1 - 0.088 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Methyltransf_4 PF02390.17 ORX67136.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Pkinase PF00069.25 ORX67137.1 - 1.9e-27 96.3 0.0 2.2e-27 96.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX67137.1 - 4.1e-14 52.5 0.0 5.3e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX67137.1 - 3.6e-09 35.9 0.1 5.1e-09 35.4 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX67137.1 - 0.0017 18.3 0.1 0.0085 16.0 0.0 2.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family VPS53_C PF16854.5 ORX67137.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus Glyco_hydro_18 PF00704.28 ORX67140.1 - 1.5e-25 90.6 2.9 1.4e-24 87.4 2.9 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Actin PF00022.19 ORX67141.1 - 1.8e-89 300.2 0.0 5.6e-88 295.3 0.0 2.0 1 1 0 1 1 1 1 Actin CBFB_NFYA PF02045.15 ORX67142.1 - 3e-29 101.4 8.1 3.5e-29 101.2 8.1 1.0 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Peptidase_M1 PF01433.20 ORX67143.1 - 2.3e-85 285.6 1.2 4.3e-85 284.7 1.2 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ORX67143.1 - 9.7e-79 265.2 7.5 9.8e-79 265.1 5.4 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ORX67143.1 - 4.9e-57 193.1 0.0 3.8e-56 190.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain WD40 PF00400.32 ORX67144.1 - 1.1e-19 70.4 15.9 1.2e-05 25.9 0.1 6.4 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67144.1 - 6.1e-10 39.3 1.2 0.38 11.1 0.0 4.8 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_Rpb1_4 PF05000.17 ORX67144.1 - 0.048 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 ANAPC9 PF12856.7 ORX67144.1 - 0.067 13.4 0.4 0.11 12.7 0.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 YL1 PF05764.13 ORX67144.1 - 0.084 13.0 0.2 0.1 12.7 0.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Cpn60_TCP1 PF00118.24 ORX67145.1 - 2.4e-137 458.5 6.1 4.8e-136 454.2 6.1 2.1 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_U59 PF04529.12 ORX67145.1 - 0.0068 15.5 0.1 0.009 15.1 0.1 1.2 1 0 0 1 1 1 1 Herpesvirus U59 protein CopK PF11525.8 ORX67147.1 - 0.15 11.7 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Copper resistance protein K eIF-1a PF01176.19 ORX67148.1 - 2.6e-06 27.1 0.0 5.9e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 Translation initiation factor 1A / IF-1 Sigma70_r4_2 PF08281.12 ORX67148.1 - 0.14 11.9 0.0 2 8.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 dUTPase PF00692.19 ORX67148.1 - 0.2 11.3 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 dUTPase PAP2_3 PF14378.6 ORX67149.1 - 1.5e-19 70.5 28.2 1.6e-13 50.8 15.6 3.5 3 1 0 3 3 3 2 PAP2 superfamily PAP2 PF01569.21 ORX67149.1 - 9.9e-06 25.4 7.0 9.9e-06 25.4 7.0 2.4 3 1 0 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 ORX67149.1 - 0.0036 17.8 5.4 0.0036 17.8 5.4 3.0 3 0 0 3 3 3 1 PAP2 superfamily C-terminal adh_short PF00106.25 ORX67154.1 - 3.8e-40 137.5 0.1 5.3e-40 137.0 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX67154.1 - 5.5e-24 85.0 0.0 5.9e-23 81.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX67154.1 - 0.0019 18.1 1.6 0.053 13.4 0.7 2.8 1 1 0 2 2 2 1 KR domain Epimerase PF01370.21 ORX67154.1 - 0.0095 15.4 0.1 0.016 14.7 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX67154.1 - 0.037 13.0 0.1 0.055 12.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NIBRIN_BRCT_II PF16508.5 ORX67155.1 - 1.6e-14 54.3 0.0 5e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 ORX67155.1 - 7.6e-07 29.4 0.7 1.7e-06 28.3 0.7 1.6 1 0 0 1 1 1 1 FHA domain tRNA_bind PF01588.20 ORX67156.1 - 1.1e-25 89.5 0.1 3.4e-25 88.0 0.1 1.9 1 0 0 1 1 1 1 Putative tRNA binding domain Rhomboid PF01694.22 ORX67157.1 - 0.042 13.9 0.0 0.042 13.9 0.0 1.1 1 0 0 1 1 1 0 Rhomboid family CwfJ_C_1 PF04677.15 ORX67160.1 - 8.3e-15 54.7 0.0 2.5e-14 53.2 0.0 1.8 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 ORX67160.1 - 4.1e-09 36.1 2.2 7e-09 35.3 2.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ORX67160.1 - 0.0065 16.5 0.8 0.0065 16.5 0.8 2.1 2 0 0 2 2 2 1 Zinc knuckle CLIP1_ZNF PF16641.5 ORX67160.1 - 0.075 12.9 0.7 0.14 12.0 0.7 1.5 1 0 0 1 1 1 0 CLIP1 zinc knuckle Fer2 PF00111.27 ORX67161.1 - 5.1e-05 23.1 0.2 0.001 19.0 0.2 2.1 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain MCR PF18509.1 ORX67161.1 - 0.073 12.7 0.4 0.12 12.0 0.4 1.3 1 0 0 1 1 1 0 Magnetochrome domain Xpo1 PF08389.12 ORX67162.1 - 6.1e-09 36.1 0.1 6e-08 32.9 0.0 2.8 2 0 0 2 2 2 1 Exportin 1-like protein Importin_rep_3 PF18806.1 ORX67162.1 - 1.6e-07 31.3 0.0 7.9e-07 29.0 0.0 2.3 2 0 0 2 2 2 1 Importin 13 repeat IBN_N PF03810.19 ORX67162.1 - 0.0026 17.6 0.1 0.015 15.2 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Importin_rep PF18773.1 ORX67162.1 - 0.069 12.9 0.3 0.16 11.7 0.1 1.7 2 0 0 2 2 2 0 Importin 13 repeat Pribosyltran PF00156.27 ORX67165.1 - 2.8e-25 88.7 0.0 3.8e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ORX67165.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 1 0 1 1 1 0 Uracil phosphoribosyltransferase IRF PF00605.17 ORX67165.1 - 0.14 12.5 0.1 0.89 9.9 0.0 2.0 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor PRTase_2 PF15609.6 ORX67165.1 - 0.15 11.5 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase LSM PF01423.22 ORX67166.1 - 1.4e-21 75.9 0.0 2.2e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 ORX67166.1 - 0.062 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain SM-ATX PF14438.6 ORX67166.1 - 0.15 12.2 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain GRP PF07172.11 ORX67166.1 - 1.3 9.8 10.2 2.4 8.9 10.2 1.6 1 0 0 1 1 1 0 Glycine rich protein family PAPS_reduct PF01507.19 ORX67167.1 - 3.6e-28 98.8 0.0 1.1e-18 67.8 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family zinc_ribbon_10 PF10058.9 ORX67169.1 - 0.14 11.9 1.2 0.47 10.2 0.3 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein SpoU_methylase PF00588.19 ORX67170.1 - 1e-27 97.1 0.0 1.5e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family Methyltrn_RNA_4 PF09936.9 ORX67170.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase TFIID_NTD2 PF04494.15 ORX67172.1 - 4.5e-29 101.3 0.9 1.4e-27 96.5 0.9 2.4 1 1 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 ORX67172.1 - 4e-19 68.6 3.2 7.5e-05 23.4 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat LisH PF08513.11 ORX67172.1 - 0.00074 19.4 0.1 0.0023 17.8 0.0 1.9 2 0 0 2 2 2 1 LisH Yip1 PF04893.17 ORX67173.1 - 4e-09 36.4 11.9 5.3e-09 36.0 11.9 1.2 1 0 0 1 1 1 1 Yip1 domain Sterol-sensing PF12349.8 ORX67173.1 - 0.037 13.9 0.4 0.063 13.1 0.3 1.4 1 1 0 1 1 1 0 Sterol-sensing domain of SREBP cleavage-activation GATA PF00320.27 ORX67174.1 - 8.6e-07 28.5 3.1 1.5e-06 27.7 3.1 1.4 1 0 0 1 1 1 1 GATA zinc finger EF-hand_7 PF13499.6 ORX67175.1 - 3.6e-24 85.0 6.8 1.6e-15 57.3 1.1 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ORX67175.1 - 2.2e-22 76.8 12.6 2e-07 30.1 0.4 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ORX67175.1 - 2.7e-20 70.5 8.5 5.5e-07 29.0 0.4 4.7 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ORX67175.1 - 7.9e-15 53.6 11.4 5.1e-05 22.6 0.7 3.8 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ORX67175.1 - 1.1e-13 50.8 8.5 1.9e-05 24.4 0.4 3.9 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ORX67175.1 - 1.9e-05 24.6 5.5 0.18 11.8 0.2 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ORX67175.1 - 0.00018 21.7 0.2 0.0069 16.7 0.1 2.8 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ORX67175.1 - 0.00022 21.5 1.1 0.014 15.7 0.4 2.9 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 ORX67175.1 - 0.016 15.5 0.6 0.22 11.9 0.1 2.6 3 1 0 3 3 3 0 EF-hand domain Velvet PF11754.8 ORX67176.1 - 2.3e-34 119.5 0.1 2.5e-34 119.4 0.1 1.0 1 0 0 1 1 1 1 Velvet factor zf-C3HC PF07967.13 ORX67178.1 - 5.1e-31 107.5 2.6 1.1e-27 96.7 0.9 2.9 1 1 1 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 ORX67178.1 - 1.3e-16 60.5 5.8 7.4e-15 54.9 0.3 2.5 2 0 0 2 2 2 2 Rsm1-like Glyco_trans_1_4 PF13692.6 ORX67179.1 - 2.9e-09 37.4 0.0 4.9e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ORX67179.1 - 3.2e-08 34.2 0.4 3.2e-08 34.2 0.4 2.4 1 1 1 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 ORX67179.1 - 5.3e-07 29.3 0.0 8.5e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX67179.1 - 3.4e-06 27.2 0.1 6.9e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ORX67179.1 - 4.2e-06 27.1 0.0 1.1e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3384 PF11864.8 ORX67180.1 - 3.3e-18 65.9 0.0 4.3e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 ORX67181.1 - 6.9e-42 143.1 0.0 1.1e-41 142.4 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 ORX67181.1 - 5.2e-18 65.3 0.3 9.3e-18 64.5 0.3 1.3 1 0 0 1 1 1 1 Tuberin SNF2_N PF00176.23 ORX67182.1 - 1.4e-44 152.2 0.0 1.7e-43 148.7 0.0 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX67182.1 - 2.4e-09 37.5 0.0 4.3e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Sec66 PF09802.9 ORX67182.1 - 0.016 14.8 0.2 0.03 13.9 0.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 RRM_1 PF00076.22 ORX67186.1 - 2.3e-08 33.7 0.0 3.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DHHC PF01529.20 ORX67189.1 - 5.3e-28 97.8 7.2 5.3e-28 97.8 7.2 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase PHD PF00628.29 ORX67190.1 - 9.5e-07 28.6 4.5 2.1e-06 27.5 4.5 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX67190.1 - 0.064 12.8 2.0 0.11 12.1 2.0 1.4 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 ORX67190.1 - 0.6 10.1 5.0 0.19 11.7 1.8 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-4CXXC_R1 PF10497.9 ORX67190.1 - 1.2 9.4 3.5 2.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 p450 PF00067.22 ORX67192.1 - 4.9e-42 144.2 0.0 5.5e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M76 PF09768.9 ORX67193.1 - 2.5e-67 225.9 2.7 3.1e-67 225.6 2.7 1.1 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M91 PF14891.6 ORX67193.1 - 0.014 15.7 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 Effector protein SprT-like PF10263.9 ORX67193.1 - 0.073 12.9 2.4 0.11 12.4 2.4 1.6 1 1 0 1 1 1 0 SprT-like family DUF1036 PF06282.11 ORX67193.1 - 0.18 12.4 2.9 0.18 12.4 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1036) Peptidase_M28 PF04389.17 ORX67194.1 - 1.2e-39 136.0 0.1 1.7e-39 135.6 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 ORX67194.1 - 0.083 12.3 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Nicastrin E1-E2_ATPase PF00122.20 ORX67195.1 - 6.3e-50 169.2 0.8 6.3e-50 169.2 0.8 2.5 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX67195.1 - 6.4e-36 124.6 1.3 3e-35 122.4 0.6 2.5 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX67195.1 - 4.5e-25 87.9 0.0 1.1e-11 45.0 0.0 2.7 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ORX67195.1 - 1.9e-07 31.7 0.0 4.9e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX67195.1 - 7.2e-06 25.9 1.1 0.0073 16.1 0.1 2.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase ALMT PF11744.8 ORX67195.1 - 0.17 10.7 0.4 0.33 9.7 0.4 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter EccE PF11203.8 ORX67195.1 - 9.5 6.6 7.7 7.3 7.0 0.0 3.8 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE Solute_trans_a PF03619.16 ORX67196.1 - 4.6e-53 180.4 1.3 5.5e-53 180.2 1.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha zf-CHY PF05495.12 ORX67197.1 - 1.4e-11 44.7 8.3 1.4e-11 44.7 8.3 3.6 4 1 0 4 4 4 1 CHY zinc finger zf-CCCH_4 PF18044.1 ORX67197.1 - 0.0018 18.1 0.2 0.0018 18.1 0.2 2.5 3 0 0 3 3 3 1 CCCH-type zinc finger Torus PF16131.5 ORX67197.1 - 0.0065 17.1 0.1 0.019 15.7 0.1 1.7 1 0 0 1 1 1 1 Torus domain zf-CCCH PF00642.24 ORX67197.1 - 0.013 15.4 1.8 0.028 14.3 0.4 2.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PuR_N PF09182.10 ORX67197.1 - 0.14 12.1 0.2 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal TT_ORF2 PF02957.15 ORX67197.1 - 5.4 8.0 7.7 0.38 11.7 0.2 2.9 2 1 1 3 3 3 0 TT viral ORF2 Xpo1 PF08389.12 ORX67198.1 - 6.1e-21 75.0 0.2 2.9e-20 72.9 0.2 2.3 1 0 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.19 ORX67198.1 - 1.6e-08 34.3 0.1 6.5e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Importin_rep PF18773.1 ORX67198.1 - 0.013 15.1 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Importin 13 repeat RIX1 PF08167.12 ORX67198.1 - 0.048 13.4 0.0 3.9 7.2 0.0 2.8 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis C5-epim_C PF06662.13 ORX67198.1 - 0.18 11.3 0.1 19 4.7 0.0 2.9 3 0 0 3 3 3 0 D-glucuronyl C5-epimerase C-terminus XPA_C PF05181.12 ORX67199.1 - 1.6e-22 79.2 2.8 2.8e-22 78.4 2.8 1.4 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 ORX67199.1 - 8.8e-05 22.5 1.6 0.00021 21.2 1.6 1.7 1 0 0 1 1 1 1 XPA protein N-terminal MscS_TM PF12794.7 ORX67200.1 - 2.3 7.0 16.9 0.23 10.3 1.4 2.4 2 1 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 COQ7 PF03232.13 ORX67201.1 - 6.4e-65 218.1 0.2 7.1e-65 218.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 ORX67201.1 - 0.013 15.9 0.0 0.033 14.6 0.0 1.6 1 1 0 1 1 1 0 Rubrerythrin Coat_F PF07875.12 ORX67201.1 - 0.12 12.7 1.7 9.6 6.5 0.1 3.1 3 0 0 3 3 3 0 Coat F domain Ferritin_2 PF13668.6 ORX67201.1 - 0.15 12.2 1.3 3.1 8.0 0.2 2.7 1 1 2 3 3 3 0 Ferritin-like domain Aa_trans PF01490.18 ORX67202.1 - 9.6e-80 268.3 31.8 1.3e-79 267.9 31.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein BUD22 PF09073.10 ORX67202.1 - 1.2 8.3 5.7 1.8 7.8 5.7 1.2 1 0 0 1 1 1 0 BUD22 DUF4611 PF15387.6 ORX67202.1 - 2.8 8.2 5.2 16 5.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Pet191_N PF10203.9 ORX67203.1 - 5.6e-22 77.8 4.5 6.2e-22 77.7 4.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 DUF4576 PF15144.6 ORX67204.1 - 0.066 13.1 0.9 84 3.1 0.0 5.1 6 2 2 8 8 8 0 Domain of unknown function (DUF4576) Metallothio_Euk PF12749.7 ORX67206.1 - 0.0054 16.9 44.0 0.0054 16.9 44.0 6.6 1 1 5 6 6 6 3 Eukaryotic metallothionein CAF1C_H4-bd PF12265.8 ORX67207.1 - 4.2e-28 97.4 0.6 9.8e-28 96.2 0.3 1.8 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ORX67207.1 - 6.8e-25 86.8 6.6 2.4e-05 25.0 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67207.1 - 1.4e-05 25.3 1.5 0.019 15.2 0.0 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX67207.1 - 8.1e-05 22.6 0.0 0.0002 21.3 0.0 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Acetyltransf_1 PF00583.25 ORX67208.1 - 2e-11 44.1 0.0 2.6e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX67208.1 - 2e-07 31.4 0.1 3.7e-07 30.5 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX67208.1 - 6.4e-07 29.4 0.0 8.3e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX67208.1 - 2.8e-06 27.2 0.0 4.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein HSP70 PF00012.20 ORX67209.1 - 1.4e-264 878.9 17.1 1.6e-264 878.7 17.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX67209.1 - 5.3e-12 45.2 4.8 8.1e-11 41.3 1.0 2.8 1 1 1 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 ORX67209.1 - 0.00023 21.0 0.3 0.0006 19.6 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Ploopntkinase3 PF18751.1 ORX67209.1 - 0.083 12.8 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Syntaxin-6_N PF09177.11 ORX67209.1 - 0.1 13.2 5.4 0.33 11.5 5.4 2.0 1 0 0 1 1 1 0 Syntaxin 6, N-terminal FtsA PF14450.6 ORX67209.1 - 1.2 9.6 16.4 3.1 8.3 0.1 4.5 3 3 0 3 3 3 0 Cell division protein FtsA DUF2415 PF10313.9 ORX67210.1 - 8.3e-12 44.8 0.4 3.5e-11 42.9 0.0 2.2 3 0 0 3 3 3 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 ORX67210.1 - 1.7e-05 25.5 1.1 0.031 15.1 0.2 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67210.1 - 1.8e-05 24.9 0.0 0.086 13.1 0.0 3.6 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 ORX67210.1 - 0.21 9.9 0.0 0.52 8.6 0.0 1.6 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz LPMO_10 PF03067.15 ORX67212.1 - 0.0095 16.6 0.0 0.016 15.9 0.0 1.4 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Fructosamin_kin PF03881.14 ORX67213.1 - 4e-87 292.1 0.0 4.8e-87 291.8 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 ORX67213.1 - 1.1e-13 51.7 0.0 1.5e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Glyco_hydro_17 PF00332.18 ORX67214.1 - 1.6e-22 80.5 2.1 2.8e-17 63.3 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Dus PF01207.17 ORX67215.1 - 1.2e-55 188.9 0.1 1.7e-55 188.3 0.1 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) IML1 PF12257.8 ORX67216.1 - 5.6e-100 334.1 0.1 6.3e-100 334.0 0.1 1.0 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DUF4221 PF13970.6 ORX67216.1 - 0.0011 18.6 1.2 0.0014 18.2 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) Reprolysin_2 PF13574.6 ORX67217.1 - 7.7e-30 104.2 2.7 1.5e-29 103.3 2.7 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ORX67217.1 - 5.9e-26 91.8 5.1 1.3e-25 90.7 5.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ORX67217.1 - 6.2e-23 81.5 0.2 1.4e-22 80.3 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 ORX67217.1 - 9.7e-11 42.3 0.0 1.8e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ORX67217.1 - 2.8e-09 37.6 20.8 2.8e-09 37.6 20.8 5.6 5 1 0 5 5 5 1 Disintegrin Reprolysin PF01421.19 ORX67217.1 - 5.1e-08 33.0 10.9 5e-06 26.6 10.9 2.3 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 ORX67217.1 - 0.00064 20.0 0.0 0.034 14.4 0.0 2.3 2 0 0 2 2 2 1 Reprolysin family propeptide Peptidase_M66 PF10462.9 ORX67217.1 - 0.023 13.7 0.2 0.058 12.3 0.0 1.7 2 0 0 2 2 2 0 Peptidase M66 Peptidase_M54 PF07998.11 ORX67217.1 - 0.25 11.3 0.6 0.43 10.5 0.6 1.3 1 0 0 1 1 1 0 Peptidase family M54 OB_NTP_bind PF07717.16 ORX67218.1 - 4e-13 49.5 0.0 8.9e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ORX67218.1 - 2.9e-07 30.4 0.0 1.6e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX67218.1 - 6.2e-07 29.8 0.0 1.5e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ORX67218.1 - 0.00038 20.8 0.0 0.0011 19.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain HA2 PF04408.23 ORX67218.1 - 0.046 14.0 0.0 0.046 14.0 0.0 2.5 3 1 0 3 3 3 0 Helicase associated domain (HA2) Tsc35 PF15079.6 ORX67218.1 - 0.12 12.0 0.2 1.8 8.1 0.2 2.3 2 0 0 2 2 2 0 Testis-specific protein 35 Methyltransf_28 PF02636.17 ORX67219.1 - 3.8e-64 216.9 0.0 6.6e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase BUD22 PF09073.10 ORX67219.1 - 0.54 9.5 8.8 1 8.6 8.8 1.4 1 0 0 1 1 1 0 BUD22 DUF4596 PF15363.6 ORX67219.1 - 0.87 9.9 5.1 0.66 10.3 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) CDC45 PF02724.14 ORX67219.1 - 1.6 7.0 7.6 2.2 6.5 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.22 ORX67220.1 - 1e-83 275.1 1.9 1.8e-21 75.7 0.4 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX67220.1 - 2.1e-28 98.3 2.6 7e-28 96.6 2.6 2.0 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 ORX67220.1 - 1.9e-06 27.6 0.0 0.0051 16.7 0.0 4.1 5 0 0 5 5 5 1 Occluded RNA-recognition motif RRM_7 PF16367.5 ORX67220.1 - 2.1e-05 24.5 0.1 4.6 7.4 0.0 4.8 4 2 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 ORX67220.1 - 0.0001 22.3 6.8 0.087 12.9 4.5 3.9 3 1 1 4 4 4 1 RNA binding motif Nup35_RRM_2 PF14605.6 ORX67220.1 - 0.00014 21.7 0.5 3.1 7.8 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 ORX67220.1 - 0.0013 18.8 0.2 0.077 13.1 0.1 3.2 3 0 0 3 3 3 1 Limkain b1 YflT PF11181.8 ORX67220.1 - 0.0022 18.5 1.2 0.059 13.9 1.4 2.8 2 0 0 2 2 2 1 Heat induced stress protein YflT SET_assoc PF11767.8 ORX67220.1 - 0.0035 16.9 0.1 2.2 8.0 0.0 3.6 4 0 0 4 4 4 1 Histone lysine methyltransferase SET associated OB_RNB PF08206.11 ORX67220.1 - 0.01 15.5 3.6 1.5 8.5 0.0 3.3 3 0 0 3 3 3 0 Ribonuclease B OB domain Cas_Cas2CT1978 PF09707.10 ORX67220.1 - 0.015 15.4 0.1 1.9 8.6 0.0 3.2 2 1 1 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) PNPase PF03726.14 ORX67220.1 - 0.046 14.2 3.8 0.047 14.2 0.1 2.6 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF4078 PF13300.6 ORX67220.1 - 1.9 8.9 17.7 0.098 13.0 5.0 4.1 4 1 1 5 5 4 0 Domain of unknown function (DUF4078) Na_H_Exchanger PF00999.21 ORX67221.1 - 2.9e-40 138.3 24.2 5.4e-40 137.3 24.2 1.5 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family UQ_con PF00179.26 ORX67222.1 - 1.1e-31 109.4 0.1 1.3e-31 109.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 ORX67222.1 - 0.0004 20.0 0.0 0.00049 19.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 ORX67222.1 - 0.0095 16.2 0.1 0.015 15.5 0.1 1.5 1 1 0 1 1 1 1 RWD domain SCAI PF12070.8 ORX67223.1 - 4.8e-141 471.3 5.8 6.1e-115 385.1 0.6 2.6 1 1 1 2 2 2 2 Protein SCAI RNF220 PF15926.5 ORX67223.1 - 2e-06 27.6 13.1 2e-05 24.4 13.1 2.6 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 AAA_15 PF13175.6 ORX67223.1 - 0.093 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Ribosomal_L28 PF00830.19 ORX67224.1 - 5.1e-17 61.8 0.1 7.6e-17 61.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L28 family Glyco_hydro_46 PF01374.18 ORX67225.1 - 1.9e-07 30.9 1.5 9.1e-07 28.7 0.5 2.4 1 1 1 2 2 2 1 Glycosyl hydrolase family 46 MCM_OB PF17207.3 ORX67226.1 - 1.6e-36 125.0 0.1 2.9e-36 124.1 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX67226.1 - 4.4e-17 62.3 0.8 1e-16 61.1 0.8 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX67226.1 - 1.1e-12 48.5 0.9 2.5e-12 47.3 0.9 1.5 1 0 0 1 1 1 1 MCM N-terminal domain MCM PF00493.23 ORX67226.1 - 1.2e-10 40.9 0.0 2.8e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 MCM P-loop domain RCS1 PF07326.11 ORX67227.1 - 0.028 14.3 0.3 0.053 13.4 0.3 1.3 1 0 0 1 1 1 0 Regulator of chromosome segregation 1 Halo_GVPC PF05465.13 ORX67227.1 - 0.29 11.4 1.9 0.98 9.7 0.1 2.6 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat MeaB PF03308.16 ORX67230.1 - 2.1e-97 325.3 0.1 3.1e-97 324.7 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ORX67230.1 - 0.00015 21.4 0.2 0.00044 19.9 0.2 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ORX67230.1 - 0.00097 19.7 0.1 0.0043 17.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX67230.1 - 0.0013 18.6 0.3 0.003 17.5 0.1 1.7 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 ORX67230.1 - 0.0035 17.6 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 ORX67230.1 - 0.0081 16.0 0.1 0.02 14.7 0.0 1.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein SpoU_methylase PF00588.19 ORX67230.1 - 0.0084 16.3 0.0 1.2 9.3 0.0 2.8 3 0 0 3 3 3 1 SpoU rRNA Methylase family AAA_24 PF13479.6 ORX67230.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ORX67230.1 - 0.025 14.3 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein CbiA PF01656.23 ORX67230.1 - 0.025 14.6 0.0 0.067 13.2 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain FtsK_SpoIIIE PF01580.18 ORX67230.1 - 0.034 13.5 0.1 7.9 5.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Fer4_NifH PF00142.18 ORX67230.1 - 0.039 13.4 0.1 0.16 11.4 0.1 1.8 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 ORX67230.1 - 0.051 12.7 0.2 0.088 12.0 0.2 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase AAA_5 PF07728.14 ORX67230.1 - 0.057 13.4 0.0 5.4 7.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 ORX67230.1 - 0.067 12.4 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain SRP54 PF00448.22 ORX67230.1 - 0.085 12.5 0.0 0.29 10.8 0.0 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ParA PF10609.9 ORX67230.1 - 0.089 12.2 1.0 0.24 10.8 0.2 1.9 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase MMR_HSR1 PF01926.23 ORX67230.1 - 0.13 12.3 0.3 0.46 10.6 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase SAP30_Sin3_bdg PF13867.6 ORX67231.1 - 2.4e-14 53.4 0.6 3.4e-14 52.9 0.6 1.2 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 CtaG_Cox11 PF04442.14 ORX67232.1 - 2.2e-49 167.3 1.3 1.2e-48 165.0 1.3 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Laminin_II PF06009.12 ORX67233.1 - 0.03 14.3 2.0 0.033 14.2 1.6 1.4 1 1 0 1 1 1 0 Laminin Domain II DUF4337 PF14235.6 ORX67233.1 - 0.092 12.9 7.8 0.11 12.6 7.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) DUF1771 PF08590.10 ORX67233.1 - 1 9.8 15.4 1.8 9.0 10.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF1771) UPF0449 PF15136.6 ORX67233.1 - 3.6 8.1 12.0 7 7.2 12.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 LMBR1 PF04791.16 ORX67233.1 - 7.4 5.4 5.5 8 5.2 5.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Nfu_N PF08712.11 ORX67234.1 - 5.2e-29 100.1 0.0 8.9e-29 99.4 0.0 1.4 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 ORX67234.1 - 3.7e-26 91.1 0.0 5.4e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain Chorismate_synt PF01264.21 ORX67234.1 - 0.097 11.4 0.0 0.21 10.3 0.0 1.5 1 0 0 1 1 1 0 Chorismate synthase SID-1_RNA_chan PF13965.6 ORX67235.1 - 0.36 9.2 0.6 0.38 9.1 0.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PPP4R2 PF09184.11 ORX67236.1 - 1.2e-08 34.9 0.0 1.4e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 PPP4R2 MerR-DNA-bind PF09278.11 ORX67236.1 - 0.15 12.6 0.4 0.44 11.1 0.0 1.9 2 0 0 2 2 2 0 MerR, DNA binding HSP70 PF00012.20 ORX67239.1 - 1.8e-79 267.6 1.7 2.5e-79 267.1 1.7 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX67239.1 - 4.4e-06 25.8 0.7 9.7e-06 24.6 0.7 1.6 1 1 0 1 1 1 1 MreB/Mbl protein Choline_kinase PF01633.20 ORX67240.1 - 1.3e-44 152.4 0.1 6.3e-42 143.6 0.0 3.0 3 1 0 3 3 3 1 Choline/ethanolamine kinase APH PF01636.23 ORX67240.1 - 2.4e-08 34.2 0.7 4.6e-08 33.3 0.7 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Suf PF05843.14 ORX67242.1 - 0.9 9.5 7.4 1.2 9.0 7.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pkinase_fungal PF17667.1 ORX67243.1 - 0.08 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase NmrA PF05368.13 ORX67244.1 - 5e-48 163.7 0.3 6.5e-48 163.3 0.3 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX67244.1 - 3.9e-17 62.7 0.1 5.8e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ORX67244.1 - 1.7e-06 27.3 0.0 2.2e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX67244.1 - 0.00014 21.4 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DXP_reductoisom PF02670.16 ORX67244.1 - 0.00092 19.9 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Semialdhyde_dh PF01118.24 ORX67244.1 - 0.0018 18.7 0.1 0.0055 17.1 0.0 1.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX67244.1 - 0.0029 17.7 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 ORX67244.1 - 0.037 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 ORX67244.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MFS_1 PF07690.16 ORX67245.1 - 6.6e-34 117.4 29.4 1.1e-33 116.7 29.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4576 PF15144.6 ORX67246.1 - 0.039 13.8 0.1 1.8e+02 2.1 0.0 4.9 6 2 2 8 8 8 0 Domain of unknown function (DUF4576) bZIP_1 PF00170.21 ORX67249.1 - 5.9e-08 32.7 15.1 5.9e-08 32.7 15.1 2.5 2 1 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX67249.1 - 0.0083 16.6 12.6 0.0083 16.6 12.6 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor Macoilin PF09726.9 ORX67249.1 - 0.016 13.8 6.5 0.034 12.7 6.5 1.4 1 0 0 1 1 1 0 Macoilin family dsrm PF00035.26 ORX67249.1 - 0.022 15.4 0.0 0.064 14.0 0.0 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif KASH_CCD PF14662.6 ORX67249.1 - 0.91 9.3 14.6 0.088 12.6 4.3 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH GrpE PF01025.19 ORX67249.1 - 1.1 8.8 8.6 0.22 11.1 2.9 2.1 2 0 0 2 2 2 0 GrpE RHH_5 PF07878.11 ORX67249.1 - 2.5 8.1 4.3 17 5.4 0.5 3.3 3 0 0 3 3 3 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 DivIC PF04977.15 ORX67249.1 - 2.6 7.9 10.8 0.27 11.0 5.4 2.1 3 0 0 3 3 3 0 Septum formation initiator bZIP_2 PF07716.15 ORX67249.1 - 8.2 6.6 28.0 0.15 12.2 16.9 2.8 2 1 1 3 3 3 0 Basic region leucine zipper Med12 PF09497.10 ORX67250.1 - 1e-17 64.2 1.5 2.3e-16 59.8 0.9 3.0 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 PARP PF00644.20 ORX67251.1 - 7.8e-26 90.9 2.1 1.3e-23 83.6 0.0 3.6 1 1 2 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 ORX67251.1 - 2.7e-08 33.8 0.8 7e-08 32.4 0.8 1.8 1 0 0 1 1 1 1 WGR domain PARP_reg PF02877.14 ORX67251.1 - 0.0051 16.9 0.4 0.011 15.8 0.4 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Oxidored-like PF09791.9 ORX67252.1 - 1.7e-11 43.6 1.3 4.9e-11 42.1 1.3 1.7 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal FAD_binding_6 PF00970.24 ORX67252.1 - 1.3e-09 38.2 0.0 2.4e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain CENP-B_dimeris PF09026.10 ORX67253.1 - 0.022 15.2 10.4 0.022 15.2 10.4 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ribosomal_L32p PF01783.23 ORX67254.1 - 7.6 6.9 6.0 2.8 8.3 0.0 2.9 3 0 0 3 3 3 0 Ribosomal L32p protein family UQ_con PF00179.26 ORX67255.1 - 2.8e-20 72.4 0.4 7e-19 67.9 0.4 2.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Complex1_LYR PF05347.15 ORX67256.1 - 3.6e-08 33.3 0.1 8.3e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX67256.1 - 5.6e-06 27.0 0.3 9.1e-06 26.3 0.3 1.3 1 1 0 1 1 1 1 Complex1_LYR-like MM_CoA_mutase PF01642.22 ORX67257.1 - 1.6e-184 614.3 2.1 3.5e-184 613.1 2.1 1.6 1 1 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 ORX67257.1 - 0.0003 20.8 0.3 0.002 18.1 0.1 2.3 2 1 1 3 3 3 1 B12 binding domain HisG_C PF08029.11 ORX67257.1 - 0.011 15.9 0.1 0.044 13.9 0.1 2.0 2 0 0 2 2 2 0 HisG, C-terminal domain PhnI PF05861.12 ORX67257.1 - 0.029 13.3 0.0 0.057 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnI) PP-binding PF00550.25 ORX67258.1 - 1.6e-13 50.8 0.2 2e-13 50.5 0.2 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ORX67258.1 - 8.4e-05 22.7 0.6 0.0001 22.4 0.6 1.2 1 0 0 1 1 1 1 Acyl-carrier TetR_C_24 PF17932.1 ORX67258.1 - 0.0063 16.8 0.0 0.0095 16.2 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain DUF1493 PF07377.12 ORX67258.1 - 0.2 12.2 0.7 0.3 11.6 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Fe-ADH PF00465.19 ORX67259.1 - 6e-67 226.0 0.3 1.5e-66 224.7 0.3 1.6 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ORX67259.1 - 2.8e-06 27.2 0.1 0.001 18.8 0.1 2.8 2 1 0 2 2 2 2 Iron-containing alcohol dehydrogenase PFK PF00365.20 ORX67259.1 - 0.048 13.0 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase B12-binding PF02310.19 ORX67259.1 - 0.12 12.4 0.0 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 B12 binding domain Aa_trans PF01490.18 ORX67260.1 - 4.3e-43 147.6 23.6 2.7e-41 141.6 23.6 2.2 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX67260.1 - 0.00071 18.7 5.3 0.00071 18.7 5.3 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family GET2 PF08690.10 ORX67260.1 - 0.096 12.3 1.0 0.19 11.4 1.0 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 DUF3040 PF11239.8 ORX67260.1 - 3.2 8.1 5.6 1.2e+02 3.0 1.6 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) adh_short_C2 PF13561.6 ORX67261.1 - 2.1e-49 168.2 4.0 3.6e-48 164.2 4.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX67261.1 - 8.1e-40 136.4 3.0 4.5e-39 133.9 3.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX67261.1 - 5.8e-06 26.3 5.2 0.00034 20.6 5.2 2.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX67261.1 - 0.00088 18.8 0.1 0.0018 17.8 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 ORX67261.1 - 0.0024 17.7 0.1 0.004 17.0 0.1 1.4 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein DAO PF01266.24 ORX67261.1 - 0.071 12.7 0.3 10 5.6 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ribosomal_S19e PF01090.19 ORX67262.1 - 8.7e-59 197.1 0.2 9.7e-59 197.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e TFIIE_beta PF02186.15 ORX67263.1 - 7.5e-14 51.8 1.9 1.7e-13 50.6 1.9 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 ORX67263.1 - 5.3e-07 29.2 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 Med28 PF11594.8 ORX67263.1 - 0.049 13.7 1.0 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit 28 HSF_DNA-bind PF00447.17 ORX67265.1 - 7.4e-05 23.3 0.0 0.13 12.9 0.0 2.2 1 1 1 2 2 2 2 HSF-type DNA-binding Crystall PF00030.19 ORX67265.1 - 0.093 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Beta/Gamma crystallin MotY_N PF18393.1 ORX67266.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 MotY N-terminal domain Topoisom_bac PF01131.20 ORX67267.1 - 1.8e-39 135.9 0.0 1.5e-36 126.3 0.0 3.2 1 1 1 2 2 2 2 DNA topoisomerase zf-GRF PF06839.12 ORX67267.1 - 2.6e-12 46.6 1.8 3.5e-11 43.0 0.4 3.0 2 0 0 2 2 2 1 GRF zinc finger zf-CCHC PF00098.23 ORX67267.1 - 6.9e-08 32.2 2.5 1.8e-07 30.9 2.5 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-C4_Topoisom PF01396.19 ORX67267.1 - 2.7e-06 27.1 0.5 9.7e-06 25.3 0.5 2.1 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger zf-CCHC_2 PF13696.6 ORX67267.1 - 0.00081 19.2 2.7 0.002 17.9 2.7 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 ORX67267.1 - 0.014 15.1 2.6 0.067 12.9 2.6 2.2 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 ORX67267.1 - 0.021 14.8 0.4 0.058 13.4 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle T6SS_VipA PF05591.12 ORX67268.1 - 0.07 12.9 0.8 0.12 12.1 0.8 1.4 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Csc2 PF18320.1 ORX67268.1 - 0.18 10.7 2.8 0.26 10.2 2.8 1.2 1 0 0 1 1 1 0 Csc2 Crispr LIAS_N PF16881.5 ORX67270.1 - 2.3e-14 53.7 3.7 5e-13 49.4 3.7 2.4 1 1 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ORX67270.1 - 4.6e-09 36.9 0.0 1.2e-08 35.6 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily APC1_C PF18122.1 ORX67270.1 - 0.036 14.0 0.0 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex sub unit 1 C-terminal domain RNA_pol_Rpb2_6 PF00562.28 ORX67271.1 - 3.1e-108 362.3 0.0 1e-107 360.6 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ORX67271.1 - 4.2e-30 104.8 0.0 4.2e-30 104.8 0.0 1.2 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ORX67271.1 - 2.1e-27 95.1 0.0 4.9e-27 93.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 ORX67271.1 - 2.8e-21 76.0 0.0 4.9e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ORX67271.1 - 5.9e-21 74.7 0.0 4.9e-20 71.7 0.0 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 ORX67271.1 - 3.7e-13 49.3 0.0 8.1e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain NmrA PF05368.13 ORX67272.1 - 3.3e-49 167.6 0.4 4.2e-49 167.2 0.4 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX67272.1 - 3.7e-16 59.6 0.2 6.1e-16 58.8 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ORX67272.1 - 1.1e-05 24.5 0.0 1.4e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX67272.1 - 0.00074 19.0 0.1 0.0011 18.5 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DXP_reductoisom PF02670.16 ORX67272.1 - 0.0009 20.0 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Semialdhyde_dh PF01118.24 ORX67272.1 - 0.0049 17.3 0.1 0.015 15.7 0.0 1.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX67272.1 - 0.013 15.6 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase KR PF08659.10 ORX67272.1 - 0.019 14.9 0.0 0.091 12.7 0.0 2.0 2 1 0 2 2 2 0 KR domain Oxidored_FMN PF00724.20 ORX67274.1 - 2.6e-73 247.2 0.0 3.2e-73 247.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ORX67274.1 - 0.0011 18.1 0.2 0.0075 15.4 0.0 2.1 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) PTPA PF03095.15 ORX67275.1 - 9.1e-115 383.2 0.0 1e-114 383.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein WD40 PF00400.32 ORX67276.1 - 6.2e-08 33.2 6.5 4 8.5 0.1 8.1 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67276.1 - 6.4e-06 26.4 1.0 1.2 9.5 0.0 5.6 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 ORX67276.1 - 0.062 12.3 0.0 0.24 10.4 0.0 1.9 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain HMG-CoA_red PF00368.18 ORX67279.1 - 6.2e-115 384.1 0.5 2e-114 382.4 0.3 2.0 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 ORX67279.1 - 1.5e-09 37.9 14.6 7.3e-06 25.9 0.2 3.3 2 1 1 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ORX67279.1 - 0.00095 17.4 6.1 0.0023 16.1 6.1 1.5 1 1 0 1 1 1 1 Patched family FtsK_gamma PF09397.10 ORX67279.1 - 0.027 14.3 0.0 0.067 13.0 0.0 1.7 1 0 0 1 1 1 0 Ftsk gamma domain ubiquitin PF00240.23 ORX67280.1 - 2.1e-07 30.6 0.0 2.6e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ORX67280.1 - 1.7e-05 25.2 0.2 0.00011 22.6 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 ORX67280.1 - 0.00051 19.8 0.1 0.00058 19.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 ORX67280.1 - 0.017 15.8 0.0 0.021 15.5 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD ICL PF00463.21 ORX67281.1 - 1.6e-253 842.0 0.0 1.8e-253 841.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ORX67281.1 - 8e-12 45.1 0.0 1.6e-11 44.1 0.0 1.5 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase LEA_3 PF03242.13 ORX67281.1 - 0.12 13.1 1.9 0.85 10.4 0.5 2.6 2 0 0 2 2 2 0 Late embryogenesis abundant protein WD40 PF00400.32 ORX67282.1 - 6.9e-18 64.7 8.7 1.6e-05 25.5 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67282.1 - 4.5e-07 30.1 0.0 1.9 8.9 0.0 4.7 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX67282.1 - 0.065 11.8 0.0 0.81 8.1 0.0 2.5 3 1 0 3 3 3 0 Cytochrome D1 heme domain adh_short PF00106.25 ORX67283.1 - 1.6e-38 132.1 1.0 2e-38 131.8 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX67283.1 - 3.6e-27 95.4 0.6 4.3e-27 95.2 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX67283.1 - 0.00077 19.4 0.2 0.001 19.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX67283.1 - 0.0048 16.4 0.0 0.047 13.1 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ORX67283.1 - 0.027 13.6 0.1 0.037 13.2 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Urm1 PF09138.11 ORX67284.1 - 2.2e-33 114.5 0.0 2.5e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 ORX67284.1 - 8.8e-05 23.1 0.0 0.00012 22.7 0.0 1.2 1 0 0 1 1 1 1 ThiS family NAD_binding_6 PF08030.12 ORX67285.1 - 1.8e-28 99.6 0.0 8e-28 97.5 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX67285.1 - 3.8e-22 78.4 0.0 9.3e-22 77.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ORX67285.1 - 4.1e-15 56.0 13.6 4.1e-15 56.0 13.6 2.5 1 1 1 2 2 2 1 Ferric reductase like transmembrane component O-FucT PF10250.9 ORX67285.1 - 0.024 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase HAUS6_N PF14661.6 ORX67286.1 - 1.4e-26 93.5 0.0 1.6e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Transferase PF02458.15 ORX67288.1 - 2.4e-09 36.3 0.0 4.9e-09 35.3 0.0 1.4 1 1 0 1 1 1 1 Transferase family AMP-binding PF00501.28 ORX67289.1 - 9.4e-70 235.3 0.0 1.4e-69 234.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme SAD_SRA PF02182.17 ORX67290.1 - 2.2e-45 154.1 0.0 2.9e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 SAD/SRA domain PHD PF00628.29 ORX67290.1 - 1.2e-05 25.0 0.5 1.2e-05 25.0 0.5 1.9 2 0 0 2 2 2 1 PHD-finger SNF2_N PF00176.23 ORX67291.1 - 1.6e-50 171.8 0.0 2.4e-50 171.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX67291.1 - 1.9e-20 73.2 0.0 1.1e-17 64.4 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ORX67291.1 - 8.5e-09 35.0 0.6 9.9e-05 21.6 0.1 2.3 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 ORX67291.1 - 4.2e-06 26.2 0.0 7.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ORX67291.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit 2-Hacid_dh_C PF02826.19 ORX67292.1 - 1.3e-54 184.3 0.0 1.7e-54 183.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX67292.1 - 9.9e-19 67.3 0.0 1.6e-18 66.6 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_7 PF13241.6 ORX67292.1 - 6.7e-05 23.3 0.0 0.00016 22.0 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding IlvN PF07991.12 ORX67292.1 - 0.0003 20.4 0.0 0.0017 17.9 0.0 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ORX67292.1 - 0.0028 18.2 0.0 0.0062 17.1 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ORX67292.1 - 0.02 15.0 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CBP_BcsO PF17037.5 ORX67292.1 - 0.022 14.9 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsO Shikimate_DH PF01488.20 ORX67292.1 - 0.059 13.4 0.0 1.8 8.6 0.0 2.5 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 ORX67292.1 - 0.068 13.4 0.0 19 5.5 0.0 2.6 2 1 0 2 2 2 0 TrkA-N domain Rossmann-like PF10727.9 ORX67292.1 - 0.071 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain PDH PF02153.17 ORX67292.1 - 0.09 11.8 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase CPSF73-100_C PF11718.8 ORX67292.1 - 0.092 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term GFO_IDH_MocA PF01408.22 ORX67292.1 - 0.14 13.0 0.0 0.27 12.1 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold AA_permease PF00324.21 ORX67293.1 - 7.3e-104 348.0 41.4 2.7e-103 346.1 41.4 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX67293.1 - 1.1e-35 123.3 40.7 3.1e-35 121.8 40.7 1.7 1 1 0 1 1 1 1 Amino acid permease PNP_UDP_1 PF01048.20 ORX67294.1 - 2.4e-34 118.6 1.3 3e-34 118.3 1.3 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PGK PF00162.19 ORX67295.1 - 1.9e-127 425.3 2.8 2.9e-81 273.4 1.2 2.0 1 1 1 2 2 2 2 Phosphoglycerate kinase ADH_zinc_N PF00107.26 ORX67295.1 - 0.12 12.3 0.9 2.1 8.3 0.1 2.9 2 1 0 3 3 3 0 Zinc-binding dehydrogenase NAGidase PF07555.13 ORX67295.1 - 0.13 11.5 0.0 0.63 9.3 0.0 1.8 1 1 0 1 1 1 0 beta-N-acetylglucosaminidase Cofilin_ADF PF00241.20 ORX67296.1 - 2.1e-40 137.3 2.2 2.5e-40 137.1 2.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SSV1_ORF_D-335 PF07935.11 ORX67296.1 - 0.056 13.7 0.0 14 6.1 0.0 2.3 2 0 0 2 2 2 0 ORF D-335-like protein Hpt PF01627.23 ORX67297.1 - 1.5e-11 44.4 0.1 2.1e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 Hpt domain Pro_isomerase PF00160.21 ORX67298.1 - 1.8e-30 106.3 0.0 3e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ORX67298.1 - 2.9e-10 39.8 0.1 6.3e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 ORX67299.1 - 5.5e-35 120.9 17.2 8e-35 120.4 17.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TM_helix PF05552.12 ORX67299.1 - 0.094 12.7 0.1 0.094 12.7 0.1 2.4 3 0 0 3 3 3 0 Conserved TM helix PPR_2 PF13041.6 ORX67300.1 - 1.3e-06 28.5 0.3 0.0087 16.2 0.0 4.8 4 1 1 5 5 5 2 PPR repeat family PPR_1 PF12854.7 ORX67300.1 - 0.00013 21.6 0.0 0.0031 17.2 0.0 3.0 3 0 0 3 3 3 1 PPR repeat PPR PF01535.20 ORX67300.1 - 0.00044 20.3 0.2 0.11 12.8 0.0 3.8 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.6 ORX67300.1 - 0.0026 17.8 0.1 21 5.3 0.0 4.0 4 0 0 4 4 4 1 Pentatricopeptide repeat domain ATP13 PF12921.7 ORX67300.1 - 0.02 14.8 0.0 16 5.4 0.0 3.4 3 0 0 3 3 3 0 Mitochondrial ATPase expression CCDC32 PF14989.6 ORX67300.1 - 0.028 14.4 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing 32 Amidohydro_1 PF01979.20 ORX67303.1 - 1.1e-65 222.2 3.0 6.3e-65 219.7 3.6 1.9 2 1 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 ORX67303.1 - 1.5e-36 125.4 0.5 3.2e-36 124.3 0.5 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 ORX67303.1 - 8.4e-23 80.6 0.3 2.9e-20 72.4 0.3 2.7 1 1 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 ORX67303.1 - 5.6e-14 52.0 0.0 7.6e-13 48.3 0.0 2.4 1 1 0 1 1 1 1 Urease beta subunit Amidohydro_3 PF07969.11 ORX67303.1 - 6.6e-08 32.5 0.2 5.1e-07 29.5 0.0 2.0 2 1 0 2 2 2 1 Amidohydrolase family Ribosomal_S19 PF00203.21 ORX67304.1 - 6.8e-26 90.0 0.2 8.7e-26 89.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Pro_CA PF00484.19 ORX67305.1 - 7.9e-47 159.4 0.0 1.2e-46 158.8 0.0 1.3 1 0 0 1 1 1 1 Carbonic anhydrase nsp7 PF08716.10 ORX67305.1 - 0.067 13.8 0.6 0.2 12.3 0.1 2.1 3 0 0 3 3 3 0 nsp7 replicase Ribosomal_L19e PF01280.20 ORX67306.1 - 5.6e-64 214.6 8.0 5.6e-64 214.6 8.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e zf-NOSIP PF15906.5 ORX67307.1 - 6e-11 42.3 0.2 1.1e-10 41.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_3 PF13920.6 ORX67307.1 - 1.6e-09 37.5 16.6 1e-05 25.3 6.7 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX67307.1 - 5.1e-06 26.3 16.7 0.00011 22.1 8.3 2.5 2 0 0 2 2 2 2 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX67307.1 - 9.1e-06 25.4 21.2 0.0085 15.9 10.5 3.0 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ORX67307.1 - 1.3e-05 25.5 17.6 0.00026 21.3 8.7 2.4 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.25 ORX67307.1 - 0.00018 21.3 18.5 0.03 14.2 8.5 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX67307.1 - 0.0004 20.3 17.3 0.058 13.4 7.6 2.5 2 0 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX67307.1 - 0.0006 19.6 17.7 0.11 12.3 7.8 2.7 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 ORX67307.1 - 0.00085 18.8 2.9 0.00085 18.8 2.9 3.0 2 1 1 3 3 3 2 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 ORX67307.1 - 0.013 15.6 16.5 0.57 10.4 1.6 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DiS_P_DiS PF06750.13 ORX67307.1 - 1.3 9.1 7.6 1.7 8.8 0.8 3.1 1 1 1 2 2 2 0 Bacterial Peptidase A24 N-terminal domain DZR PF12773.7 ORX67307.1 - 5.4 7.1 14.4 3.7 7.6 6.2 3.3 2 1 0 2 2 2 0 Double zinc ribbon Ran_BP1 PF00638.18 ORX67308.1 - 0.0026 18.0 0.1 0.0063 16.8 0.1 1.7 1 0 0 1 1 1 1 RanBP1 domain RNA_pol_Rbc25 PF08292.12 ORX67308.1 - 9 6.5 12.4 2.6 8.3 2.0 3.1 2 1 1 3 3 3 0 RNA polymerase III subunit Rpc25 DUF4748 PF15932.5 ORX67309.1 - 1.1e-06 28.3 0.2 1.5e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) Zip PF02535.22 ORX67311.1 - 6.5e-39 134.1 16.4 6.5e-39 134.1 16.4 2.6 2 1 0 2 2 2 1 ZIP Zinc transporter PAGK PF15284.6 ORX67311.1 - 0.14 12.1 1.8 0.47 10.4 0.3 2.5 2 0 0 2 2 2 0 Phage-encoded virulence factor AF-4 PF05110.13 ORX67311.1 - 1.2 7.1 16.4 2.1 6.3 16.4 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PAS_9 PF13426.7 ORX67312.1 - 2.8e-05 24.3 0.0 0.029 14.6 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 ORX67312.1 - 0.00045 20.2 0.0 0.0065 16.5 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 ORX67312.1 - 0.036 14.3 0.0 0.67 10.3 0.0 2.3 2 0 0 2 2 2 0 PAS fold MFS_1 PF07690.16 ORX67313.1 - 1.6e-34 119.4 29.4 2.2e-34 119.0 29.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 ORX67313.1 - 1.6e-06 27.0 12.9 0.0038 15.8 0.3 2.4 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 ORX67313.1 - 4.8e-05 22.4 2.1 4.8e-05 22.4 2.1 1.7 2 0 0 2 2 2 1 MFS_1 like family Frag1 PF10277.9 ORX67313.1 - 0.99 8.9 11.6 0.12 11.9 4.5 2.6 2 1 1 3 3 3 0 Frag1/DRAM/Sfk1 family Chorismate_synt PF01264.21 ORX67314.1 - 1.6e-105 352.5 0.3 3.4e-74 249.5 0.1 2.0 1 1 1 2 2 2 2 Chorismate synthase E1_UFD PF09358.10 ORX67314.1 - 0.17 12.6 0.1 0.3 11.8 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin fold domain GCN5L1 PF06320.13 ORX67315.1 - 7.4e-28 97.0 0.8 9e-28 96.7 0.8 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) 7TMR-HDED PF07697.11 ORX67315.1 - 0.025 14.7 0.2 0.03 14.4 0.2 1.1 1 0 0 1 1 1 0 7TM-HD extracellular LMBR1 PF04791.16 ORX67315.1 - 0.043 12.7 0.2 0.047 12.6 0.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2789 PF10982.8 ORX67315.1 - 0.062 13.5 1.2 0.18 12.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) RNA_pol_Rpb8 PF03870.15 ORX67316.1 - 3.2e-49 166.7 0.1 3.6e-49 166.5 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 Mito_carr PF00153.27 ORX67317.1 - 1.3e-36 124.4 5.6 3.2e-17 62.2 0.0 3.7 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF3147 PF11345.8 ORX67317.1 - 0.014 15.7 0.4 7.1 7.0 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3147) Abhydrolase_3 PF07859.13 ORX67320.1 - 3.1e-36 125.2 0.0 6.3e-36 124.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX67320.1 - 3.5e-11 42.6 0.0 5.4e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 ORX67320.1 - 0.025 13.9 0.0 0.087 12.1 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 zf-FPG_IleRS PF06827.14 ORX67320.1 - 0.19 11.6 0.0 0.6 10.0 0.0 1.9 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS LysM PF01476.20 ORX67321.1 - 5.6e-21 74.3 0.0 1.6e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 LysM domain DUF21 PF01595.20 ORX67323.1 - 3.1e-36 124.7 0.0 4.3e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ORX67323.1 - 6.3e-06 26.5 2.5 0.0099 16.3 0.4 3.4 3 0 0 3 3 3 2 CBS domain Zip PF02535.22 ORX67327.1 - 1e-13 51.3 0.6 1.5e-13 50.7 0.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter PhoR PF11808.8 ORX67327.1 - 0.44 11.0 4.7 0.15 12.5 0.6 2.3 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Zip PF02535.22 ORX67328.1 - 3e-22 79.3 11.2 3.7e-12 46.1 6.3 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter DUF4328 PF14219.6 ORX67328.1 - 0.039 13.5 0.1 0.08 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) TetR_C_13 PF16925.5 ORX67329.1 - 0.019 14.9 0.3 0.03 14.3 0.3 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TFIIA PF03153.13 ORX67329.1 - 0.06 13.3 11.3 0.065 13.2 11.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CHGN PF05679.16 ORX67329.1 - 0.12 11.2 2.5 0.14 11.0 2.5 1.0 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase Spt20 PF12090.8 ORX67329.1 - 0.83 9.2 14.8 1.1 8.8 14.8 1.2 1 0 0 1 1 1 0 Spt20 family DUF4175 PF13779.6 ORX67329.1 - 1.7 6.5 10.9 2.1 6.1 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) MFS_1 PF07690.16 ORX67330.1 - 5.3e-36 124.3 29.1 8e-36 123.7 29.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3679 PF12438.8 ORX67330.1 - 0.11 12.2 0.5 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3679) MFS_1 PF07690.16 ORX67331.1 - 2e-29 102.7 27.9 4.3e-29 101.5 27.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily PAS_3 PF08447.12 ORX67332.1 - 0.00088 19.5 0.0 0.47 10.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 ORX67332.1 - 0.028 14.6 0.0 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 PAS domain RTT107_BRCT_5 PF16770.5 ORX67332.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.6 1 1 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Opi1 PF08618.10 ORX67333.1 - 2.9e-35 122.3 3.6 3e-31 109.1 3.5 2.1 1 1 1 2 2 2 2 Transcription factor Opi1 PaaB PF06243.11 ORX67333.1 - 0.018 15.3 0.1 0.047 13.9 0.1 1.7 1 0 0 1 1 1 0 Phenylacetic acid degradation B WD40 PF00400.32 ORX67334.1 - 2e-28 98.0 10.5 1.1e-08 35.5 0.6 8.0 7 1 0 7 7 7 4 WD domain, G-beta repeat Hira PF07569.11 ORX67334.1 - 1.2e-24 87.3 0.0 2.8e-24 86.1 0.0 1.6 1 1 0 1 1 1 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 ORX67334.1 - 2.7e-07 30.8 0.0 0.79 10.1 0.0 5.4 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 ORX67334.1 - 6.7e-07 29.0 1.2 2.4e-06 27.2 1.2 2.0 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 ORX67334.1 - 0.0015 18.4 0.0 3.3 7.8 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ORX67334.1 - 0.021 13.8 0.8 0.19 10.6 0.0 2.6 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CDC27 PF09507.10 ORX67334.1 - 0.072 12.5 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GATA PF00320.27 ORX67338.1 - 8.5e-16 57.3 2.7 1.1e-15 57.0 2.7 1.1 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX67338.1 - 0.021 14.3 1.7 0.028 13.9 1.7 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX67338.1 - 0.025 14.7 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_3 PF13878.6 ORX67338.1 - 0.038 13.8 1.8 1.5 8.7 0.8 2.2 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO TDP43_N PF18694.1 ORX67338.1 - 0.065 13.1 0.0 0.078 12.8 0.0 1.1 1 0 0 1 1 1 0 Transactive response DNA-binding protein N-terminal domain zf-ribbon_3 PF13248.6 ORX67338.1 - 0.33 10.4 4.2 6.1 6.4 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Peptidase_M1 PF01433.20 ORX67339.1 - 4.7e-69 232.3 0.2 9.2e-69 231.3 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ORX67339.1 - 1.9e-50 171.6 0.0 3.4e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 ORX67339.1 - 1.1e-30 107.3 4.0 5.4e-30 105.0 4.0 2.2 1 1 0 1 1 1 1 ERAP1-like C-terminal domain DUF1648 PF07853.11 ORX67339.1 - 0.04 13.6 0.0 8.1 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1648) ABC_tran PF00005.27 ORX67340.1 - 2.6e-21 76.6 0.1 1.1e-10 42.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ORX67340.1 - 8.7e-17 60.8 0.2 2.7e-16 59.2 0.2 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC2_membrane PF01061.24 ORX67340.1 - 1.1e-16 60.9 20.6 1.3e-13 50.8 0.6 2.7 2 1 1 3 3 3 2 ABC-2 type transporter RsgA_GTPase PF03193.16 ORX67340.1 - 4.1e-08 33.3 0.1 9.9e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ORX67340.1 - 3.2e-06 26.8 1.3 0.00087 19.0 0.4 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX67340.1 - 0.00012 22.4 0.2 0.16 12.2 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ORX67340.1 - 0.00024 21.5 0.3 0.33 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 ORX67340.1 - 0.00036 20.2 0.1 0.034 13.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX67340.1 - 0.0027 17.8 0.1 0.21 11.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX67340.1 - 0.0054 16.0 1.3 5.2 6.3 0.1 3.2 3 0 0 3 3 3 1 Zeta toxin ABC_trans_N PF14510.6 ORX67340.1 - 0.0088 16.6 0.2 0.024 15.3 0.2 1.8 1 1 0 1 1 1 1 ABC-transporter N-terminal AAA_18 PF13238.6 ORX67340.1 - 0.0088 16.6 0.2 1.1 9.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ORX67340.1 - 0.0093 16.0 0.1 3 8.0 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 ORX67340.1 - 0.037 13.8 0.3 2.1 8.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ORX67340.1 - 0.048 13.2 1.8 0.23 11.0 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ORX67340.1 - 0.085 13.1 2.0 0.4 10.9 0.5 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 ORX67340.1 - 0.1 13.0 0.1 8.4 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX67340.1 - 0.11 12.5 1.2 0.88 9.5 0.2 2.2 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 ORX67340.1 - 0.13 12.8 0.8 0.4 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain NAD_binding_2 PF03446.15 ORX67340.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AAA_24 PF13479.6 ORX67340.1 - 0.15 11.8 0.3 0.67 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ORX67340.1 - 0.17 11.6 1.1 1.2 8.9 0.4 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SIR2 PF02146.17 ORX67376.1 - 1e-58 198.2 0.0 1.4e-58 197.8 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ORX67376.1 - 0.043 13.6 0.1 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain NARG2_C PF10505.9 ORX67377.1 - 4.4e-16 59.0 0.0 7.1e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus MSP1_C PF07462.11 ORX67377.1 - 4.8 5.8 4.2 8.6 4.9 4.2 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CoaE PF01121.20 ORX67378.1 - 8.7e-58 194.9 0.0 1e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_28 PF13521.6 ORX67378.1 - 0.0094 16.2 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX67378.1 - 0.063 13.8 0.3 0.16 12.5 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX67378.1 - 0.084 13.0 0.0 0.2 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain THP2 PF09432.10 ORX67378.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Tho complex subunit THP2 RabGAP-TBC PF00566.18 ORX67379.1 - 1.3e-51 175.3 0.0 1.6e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1077 PF06417.12 ORX67380.1 - 1.1e-38 131.8 2.8 1.3e-38 131.6 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) MreD PF04093.12 ORX67380.1 - 0.0011 19.1 1.2 0.024 14.7 0.2 2.0 2 0 0 2 2 2 2 rod shape-determining protein MreD DUF2781 PF10914.8 ORX67381.1 - 7.7e-37 127.0 8.8 9.2e-37 126.7 8.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) PH_9 PF15410.6 ORX67382.1 - 9.8e-06 25.9 0.0 3.3e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain TFIIA PF03153.13 ORX67382.1 - 0.007 16.4 17.3 0.007 16.4 17.3 3.4 1 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit PH PF00169.29 ORX67382.1 - 0.014 15.8 0.4 0.11 13.1 0.1 2.5 3 1 0 3 3 3 0 PH domain PBP1_TM PF14812.6 ORX67382.1 - 2.8 8.4 6.8 2.5 8.5 1.7 3.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Acetyltransf_7 PF13508.7 ORX67383.1 - 4.5e-06 27.0 0.0 8.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX67383.1 - 1.9e-05 24.6 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX67383.1 - 0.00012 22.3 0.0 0.00026 21.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PHD PF00628.29 ORX67383.1 - 0.0017 18.2 7.8 0.0017 18.2 7.8 2.0 2 0 0 2 2 2 1 PHD-finger Acetyltransf_9 PF13527.7 ORX67383.1 - 0.063 13.4 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1294 PF06961.13 ORX67383.1 - 0.12 12.6 0.1 0.27 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) DUF2793 PF10983.8 ORX67383.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2793) C1_1 PF00130.22 ORX67383.1 - 1.7 8.6 9.2 0.64 9.9 5.0 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Copper-fist PF00649.18 ORX67384.1 - 9e-23 79.5 1.8 9e-23 79.5 1.8 2.1 2 1 0 2 2 2 1 Copper fist DNA binding domain Metallothio_Pro PF02069.16 ORX67384.1 - 0.013 15.7 0.8 0.013 15.7 0.8 2.4 2 1 0 2 2 2 0 Prokaryotic metallothionein GPR15L PF15854.5 ORX67384.1 - 0.99 9.7 7.5 1.1 9.5 7.5 1.1 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 Glyco_transf_5 PF08323.11 ORX67387.1 - 0.054 13.2 0.0 0.075 12.7 0.0 1.1 1 0 0 1 1 1 0 Starch synthase catalytic domain Tom22 PF04281.13 ORX67389.1 - 4.5e-34 117.2 1.4 5.5e-34 116.9 1.4 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Zw10 PF06248.13 ORX67390.1 - 7.4e-41 140.3 0.0 1.6e-40 139.2 0.0 1.5 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Endonuclease_5 PF04493.14 ORX67391.1 - 9.6e-60 201.6 0.0 1.2e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.16 ORX67391.1 - 0.023 14.1 0.1 0.038 13.4 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF99 AMP-binding PF00501.28 ORX67392.1 - 2.3e-104 349.4 0.0 3.1e-104 348.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX67392.1 - 3.1e-11 44.1 0.0 1.7e-10 41.7 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Metallophos PF00149.28 ORX67393.1 - 9.9e-38 130.7 0.1 1.3e-37 130.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX67393.1 - 3e-05 24.3 0.9 6.3e-05 23.3 0.9 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PGM_PMM_III PF02880.16 ORX67394.1 - 3.5e-26 91.6 0.0 6.7e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 ORX67394.1 - 2.7e-22 79.0 0.3 1.1e-21 77.1 0.3 1.8 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ORX67394.1 - 9.5e-10 39.0 0.0 3.7e-09 37.1 0.0 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ORX67394.1 - 5.2e-06 26.5 0.1 1.7e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Vps5 PF09325.10 ORX67395.1 - 2.5e-59 200.7 0.4 3.9e-59 200.1 0.4 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ORX67395.1 - 3.4e-23 81.8 0.1 3.1e-22 78.7 0.0 2.5 3 0 0 3 3 3 1 PX domain BAR PF03114.18 ORX67395.1 - 0.024 14.3 1.8 0.58 9.8 0.2 2.2 2 0 0 2 2 2 0 BAR domain BAR_3_WASP_bdg PF10456.9 ORX67395.1 - 0.056 12.9 0.3 0.25 10.8 0.1 2.0 1 1 1 2 2 2 0 WASP-binding domain of Sorting nexin protein aGPT-Pplase1 PF18723.1 ORX67395.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Arfaptin PF06456.13 ORX67395.1 - 0.31 10.6 2.1 4 6.9 0.4 2.2 2 0 0 2 2 2 0 Arfaptin-like domain tRNA-synt_2b PF00587.25 ORX67397.1 - 4.4e-24 85.4 0.0 7.3e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX67397.1 - 1e-10 41.8 3.8 2e-10 40.8 3.8 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain BBP1_C PF15272.6 ORX67397.1 - 0.0014 18.5 0.6 0.0022 17.8 0.6 1.2 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal Syntaxin-6_N PF09177.11 ORX67397.1 - 0.02 15.4 1.1 0.16 12.5 1.1 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal AMP-binding PF00501.28 ORX67398.1 - 2.9e-56 190.9 0.2 4.5e-56 190.2 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DAGAT PF03982.13 ORX67399.1 - 3.9e-63 213.1 0.0 4.5e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase VirB3 PF05101.13 ORX67399.1 - 0.018 15.3 5.2 18 5.6 1.7 3.4 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein Vezatin PF12632.7 ORX67400.1 - 1.5e-10 40.9 1.6 1.1e-09 38.1 1.6 2.1 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes SLATT_1 PF18181.1 ORX67400.1 - 0.13 12.2 3.8 0.078 12.9 1.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 CCDC168_N PF15804.5 ORX67403.1 - 0.06 13.2 0.0 0.068 13.0 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 168 DUF2373 PF10180.9 ORX67405.1 - 4.4e-22 77.7 0.9 7.7e-22 76.9 0.9 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Fez1 PF06818.15 ORX67405.1 - 1.3 9.5 12.6 1.9 8.9 6.3 2.1 2 0 0 2 2 2 0 Fez1 Erg28 PF03694.13 ORX67406.1 - 2e-34 118.2 3.7 2.4e-34 118.0 3.7 1.0 1 0 0 1 1 1 1 Erg28 like protein Cg6151-P PF10233.9 ORX67407.1 - 7e-12 45.7 3.7 1.4e-11 44.7 3.9 1.5 1 1 1 2 2 2 1 Uncharacterized conserved protein CG6151-P Peptidase_U4 PF03419.13 ORX67407.1 - 0.29 10.4 4.9 0.37 10.0 4.9 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Peptidase_S10 PF00450.22 ORX67408.1 - 1.6e-114 383.6 0.3 2e-114 383.2 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase ThiF PF00899.21 ORX67410.1 - 4.7e-24 85.1 0.0 7.6e-24 84.4 0.0 1.5 1 1 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 ORX67410.1 - 0.0031 17.9 0.1 0.0092 16.4 0.1 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding IPPT PF01715.17 ORX67410.1 - 0.14 11.9 0.0 6 6.6 0.0 2.2 2 0 0 2 2 2 0 IPP transferase HLH PF00010.26 ORX67412.1 - 3.1e-18 65.5 1.7 3.1e-18 65.5 1.7 2.0 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain Spt20 PF12090.8 ORX67412.1 - 0.014 15.0 9.0 0.015 14.9 9.0 1.2 1 0 0 1 1 1 0 Spt20 family MtrB PF05440.12 ORX67412.1 - 0.033 14.6 0.0 0.054 13.9 0.0 1.4 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B TFIIA PF03153.13 ORX67412.1 - 0.11 12.5 11.9 0.11 12.5 11.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAXX PF15384.6 ORX67412.1 - 0.12 12.1 1.9 0.18 11.5 1.9 1.2 1 0 0 1 1 1 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Abi_C PF14355.6 ORX67412.1 - 0.16 12.1 3.0 0.61 10.2 1.6 2.2 1 1 1 2 2 2 0 Abortive infection C-terminus DUF4407 PF14362.6 ORX67412.1 - 0.45 9.8 8.1 0.51 9.6 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MCU PF04678.13 ORX67412.1 - 0.71 9.9 3.9 0.87 9.7 3.7 1.3 1 1 0 1 1 1 0 Mitochondrial calcium uniporter HAUS6_N PF14661.6 ORX67412.1 - 1 8.9 6.8 1.3 8.6 6.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Activator_LAG-3 PF11498.8 ORX67412.1 - 2.7 6.8 22.3 3.7 6.4 22.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SNase PF00565.17 ORX67413.1 - 5.2e-23 81.6 0.1 7.9e-23 81.0 0.1 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Bac_surface_Ag PF01103.23 ORX67414.1 - 1.7e-45 155.9 0.0 2.2e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Surface antigen ShlB PF03865.13 ORX67414.1 - 0.09 12.2 0.2 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB tRNA_int_endo PF01974.17 ORX67415.1 - 3.3e-17 62.3 0.0 5.5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain adh_short PF00106.25 ORX67417.1 - 1.2e-39 135.8 0.6 1.5e-39 135.5 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX67417.1 - 7e-27 94.5 0.2 8.4e-27 94.2 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX67417.1 - 8.4e-07 29.1 0.9 1.3e-06 28.5 0.6 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX67417.1 - 3.9e-05 23.2 0.1 0.0001 21.9 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX67417.1 - 0.012 15.0 0.0 0.39 10.1 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 ORX67417.1 - 0.042 13.2 0.1 0.095 12.0 0.1 1.4 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain HC2 PF07382.11 ORX67419.1 - 4.9e-19 69.2 17.8 5.7e-05 23.3 5.8 5.2 1 1 4 5 5 5 4 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.11 ORX67419.1 - 0.019 14.8 62.7 1.3 8.8 0.1 10.2 1 1 10 11 11 11 0 African swine fever virus J13L protein OB_NTP_bind PF07717.16 ORX67423.1 - 7e-25 87.2 0.0 1.3e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 ORX67424.1 - 4.4e-08 33.4 0.3 8e-08 32.5 0.3 1.4 1 0 0 1 1 1 1 S1 RNA binding domain UMP1 PF05348.11 ORX67425.1 - 1.4e-26 93.1 0.2 1.7e-26 92.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 PhyH PF05721.13 ORX67426.1 - 3.5e-15 56.8 0.0 2.2e-13 50.9 0.0 2.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) UQ_con PF00179.26 ORX67428.1 - 1.7e-20 73.1 0.0 2.6e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Dna2 PF08696.11 ORX67429.1 - 1.7e-53 181.5 0.0 2.8e-53 180.8 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 PDDEXK_1 PF12705.7 ORX67429.1 - 3.6e-13 50.0 0.0 6.3e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.17 ORX67429.1 - 7.5e-11 42.4 0.0 1.4e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF83 FA_hydroxylase PF04116.13 ORX67430.1 - 3.8e-13 49.9 13.4 3.8e-13 49.9 13.4 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 ORX67430.1 - 0.0023 18.0 0.0 0.0094 16.1 0.0 2.0 1 1 1 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain TMEM189_B_dmain PF10520.9 ORX67430.1 - 0.023 14.9 4.1 0.3 11.2 1.7 2.4 1 1 1 2 2 2 0 B domain of TMEM189, localisation domain SecY PF00344.20 ORX67431.1 - 6.2e-61 206.3 10.5 9.2e-61 205.8 10.5 1.3 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 ORX67431.1 - 1.4e-18 66.4 0.3 5.2e-18 64.6 0.3 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p DinB PF05163.12 ORX67432.1 - 0.0024 17.8 0.3 0.005 16.8 0.3 1.5 1 1 0 1 1 1 1 DinB family DinB_2 PF12867.7 ORX67432.1 - 0.037 14.5 0.6 0.12 12.8 0.6 1.8 1 1 0 1 1 1 0 DinB superfamily FAD_binding_1 PF00667.20 ORX67433.1 - 3.8e-27 95.3 0.0 7.3e-21 74.8 0.0 2.2 1 1 1 2 2 2 2 FAD binding domain Flavodoxin_1 PF00258.25 ORX67433.1 - 1.4e-12 48.0 0.0 1.8e-09 37.9 0.0 2.5 1 1 1 2 2 2 2 Flavodoxin NAD_binding_1 PF00175.21 ORX67433.1 - 0.00085 19.9 0.0 0.0021 18.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Novirhabdo_Nv PF05554.11 ORX67433.1 - 0.019 14.7 0.1 0.038 13.7 0.1 1.4 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein Iwr1 PF08574.10 ORX67434.1 - 7.1e-13 49.4 10.8 7.1e-13 49.4 10.8 3.0 4 0 0 4 4 4 1 Transcription factor Iwr1 Transferase PF02458.15 ORX67435.1 - 7.6e-10 38.0 0.0 4.4e-06 25.6 0.0 2.0 2 0 0 2 2 2 2 Transferase family Glyco_transf_22 PF03901.17 ORX67436.1 - 5.5e-58 197.2 16.3 6.6e-58 196.9 16.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DC_STAMP PF07782.13 ORX67436.1 - 0.093 12.5 4.0 0.17 11.7 4.0 1.4 1 0 0 1 1 1 0 DC-STAMP-like protein Peptidase_S28 PF05577.12 ORX67438.1 - 4.7e-43 147.6 0.2 5.4e-43 147.4 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 ORX67438.1 - 0.11 12.1 0.3 0.16 11.6 0.3 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold DHFR_2 PF06442.11 ORX67440.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 R67 dihydrofolate reductase DUF3320 PF11784.8 ORX67440.1 - 0.67 10.0 2.4 1.6 8.8 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3320) WSS_VP PF12175.8 ORX67443.1 - 0.15 11.5 0.0 0.16 11.4 0.0 1.0 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP NmrA PF05368.13 ORX67444.1 - 7.3e-46 156.6 0.0 8.6e-46 156.4 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX67444.1 - 1.9e-10 40.9 0.1 4.3e-10 39.8 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ORX67444.1 - 2.3e-08 33.8 0.1 3.4e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX67444.1 - 8.7e-05 21.7 0.0 0.00012 21.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 ORX67444.1 - 0.0011 18.9 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 KR domain HpcH_HpaI PF03328.14 ORX67444.1 - 0.026 13.6 0.0 0.049 12.8 0.0 1.4 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family Polysacc_synt_2 PF02719.15 ORX67444.1 - 0.17 11.0 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Amidoligase_2 PF12224.8 ORX67445.1 - 0.087 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme 2-ph_phosp PF04029.14 ORX67445.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase AKAP7_NLS PF10469.9 ORX67446.1 - 3.9e-28 98.8 0.0 5.8e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX67446.1 - 2.6e-05 24.2 0.0 7.1e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily RRM_1 PF00076.22 ORX67447.1 - 3.5e-35 119.6 0.5 2.1e-18 65.9 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX67447.1 - 4e-06 26.9 0.1 0.08 13.1 0.0 2.9 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 ORX67447.1 - 2.4e-05 24.2 0.1 0.17 11.9 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ORX67447.1 - 0.00035 20.4 0.0 0.041 13.7 0.1 3.0 2 1 0 2 2 2 1 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 ORX67447.1 - 0.021 14.7 0.1 8.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Chromo PF00385.24 ORX67448.1 - 1.4e-09 37.7 1.3 1.4e-09 37.7 1.3 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.8 ORX67448.1 - 4.3e-08 32.7 0.1 5.3e-07 29.1 0.1 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Helicase_C PF00271.31 ORX67448.1 - 0.051 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Helicase conserved C-terminal domain Sugar_tr PF00083.24 ORX67449.1 - 9.2e-76 255.5 23.0 3e-75 253.8 23.0 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX67449.1 - 1.5e-17 63.6 26.4 1.5e-17 63.6 26.4 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Cyclin_N PF00134.23 ORX67450.1 - 3.5e-11 42.9 0.0 4.5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX67450.1 - 2.4e-06 28.0 0.0 2.8e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Cyclin HLH PF00010.26 ORX67451.1 - 9.6e-13 47.9 0.7 1.6e-12 47.1 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RWD PF05773.22 ORX67452.1 - 3.5e-14 53.1 0.9 6.4e-14 52.2 0.9 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 ORX67452.1 - 0.00027 21.4 5.3 0.00027 21.4 5.3 2.5 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 NDK PF00334.19 ORX67455.1 - 2.5e-51 173.2 0.0 2.9e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Rhomboid PF01694.22 ORX67456.1 - 7e-27 94.3 4.9 7e-27 94.3 4.9 1.4 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ORX67456.1 - 0.0019 18.8 0.0 0.0042 17.6 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) MFS_1 PF07690.16 ORX67457.1 - 3.4e-33 115.0 14.3 3.4e-33 115.0 14.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX67457.1 - 0.36 10.1 12.9 0.48 9.7 0.4 3.0 2 1 0 3 3 3 0 Uncharacterised MFS-type transporter YbfB PHD PF00628.29 ORX67458.1 - 1.8e-10 40.6 9.3 3.4e-10 39.6 9.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX67458.1 - 0.01 15.4 5.1 0.019 14.5 5.1 1.4 1 0 0 1 1 1 0 PHD-finger zf-CW PF07496.15 ORX67458.1 - 0.037 14.1 2.4 0.093 12.8 2.4 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger TMEM208_SND2 PF05620.11 ORX67459.1 - 7.9e-38 129.9 0.3 8.9e-38 129.7 0.3 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Pex2_Pex12 PF04757.14 ORX67459.1 - 0.04 13.5 1.0 0.89 9.1 1.0 2.3 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region CHCH PF06747.13 ORX67460.1 - 2.4e-06 27.5 11.4 9.3e-05 22.4 5.0 2.3 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 ORX67460.1 - 0.0048 16.9 10.0 0.037 14.0 3.6 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 ORX67460.1 - 0.22 11.3 5.5 0.14 11.9 1.1 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 ORX67460.1 - 1.3 9.4 11.9 6.4 7.2 3.5 2.8 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 ORX67460.1 - 1.8 8.7 11.9 4.7 7.3 4.5 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like GILT PF03227.16 ORX67462.1 - 5.4e-14 52.3 0.1 7.9e-14 51.8 0.1 1.2 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Prenyltrans PF00432.21 ORX67462.1 - 0.0083 15.8 0.5 0.029 14.1 0.5 1.9 1 0 0 1 1 1 1 Prenyltransferase and squalene oxidase repeat zf-CCCH_8 PF18633.1 ORX67462.1 - 0.14 12.3 0.4 0.3 11.2 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger antiviral protein (ZAP) zinc finger domain 3 AMPK1_CBM PF16561.5 ORX67463.1 - 2.3e-07 30.9 0.0 4.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 ORX67463.1 - 0.01 16.2 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Pur_ac_phosph_N PF16656.5 ORX67463.1 - 0.01 16.4 0.9 0.051 14.1 0.0 2.7 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain UPF0113_N PF17833.1 ORX67464.1 - 0.17 12.5 0.0 0.22 12.1 0.0 1.2 1 0 0 1 1 1 0 UPF0113 Pre-PUA domain UQ_con PF00179.26 ORX67465.1 - 1e-22 80.3 0.1 1.3e-22 80.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX67465.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 ORX67465.1 - 0.12 12.6 0.1 0.28 11.5 0.0 1.6 2 0 0 2 2 2 0 RWD domain zf-rbx1 PF12678.7 ORX67466.1 - 1.7e-07 31.4 7.7 2.9e-07 30.7 7.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ORX67466.1 - 5.8e-06 26.6 10.1 1.5e-05 25.2 10.1 1.7 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX67466.1 - 7.1e-05 22.7 1.5 7.1e-05 22.7 1.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX67466.1 - 0.00016 21.5 7.4 0.00034 20.4 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX67466.1 - 0.00037 20.5 5.0 0.00052 20.0 5.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ORX67466.1 - 0.0011 19.1 4.8 0.0011 19.1 4.8 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ORX67466.1 - 0.0019 18.2 7.2 0.0037 17.2 7.2 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 ORX67466.1 - 0.011 15.5 7.3 0.12 12.1 7.3 2.5 1 1 0 1 1 1 0 RING-like zinc finger Pellino PF04710.14 ORX67466.1 - 0.012 14.3 0.3 0.013 14.2 0.3 1.1 1 0 0 1 1 1 0 Pellino zf-C3HC4_2 PF13923.6 ORX67466.1 - 0.042 13.7 13.2 1.3 9.0 13.2 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 ORX67466.1 - 0.14 12.0 4.2 0.24 11.3 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 ORX67466.1 - 0.14 12.0 3.9 0.3 10.9 3.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 ORX67466.1 - 0.31 10.9 10.3 0.82 9.6 10.3 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX67466.1 - 2.6 8.0 12.3 14 5.6 12.3 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX67466.1 - 5.6 6.7 12.4 0.82 9.3 6.8 2.2 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type GHMP_kinases_N PF00288.26 ORX67467.1 - 5.2e-18 65.0 1.3 1.3e-17 63.7 1.3 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX67467.1 - 7.5e-07 29.4 0.2 2.5e-06 27.8 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 ORX67467.1 - 0.0021 17.6 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Aim19 PF10315.9 ORX67468.1 - 8.7e-21 74.4 6.9 9.8e-21 74.2 6.9 1.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Tmemb_14 PF03647.13 ORX67468.1 - 0.002 18.8 1.1 0.0026 18.5 1.1 1.3 1 1 0 1 1 1 1 Transmembrane proteins 14C AMP-binding PF00501.28 ORX67469.1 - 5e-99 331.8 0.1 6.3e-99 331.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX67469.1 - 7.6e-12 46.0 0.6 7.6e-12 46.0 0.6 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RRM_3 PF08777.11 ORX67470.1 - 9.6e-14 51.3 0.3 2.4e-11 43.6 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif La PF05383.17 ORX67470.1 - 3e-13 49.6 0.0 7.8e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ORX67470.1 - 2.3e-08 33.8 0.2 1.5e-05 24.8 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDHD PF02862.17 ORX67471.1 - 0.001 19.3 3.7 0.001 19.3 3.7 3.4 3 1 0 3 3 2 1 DDHD domain LisH PF08513.11 ORX67471.1 - 0.0018 18.2 0.4 0.0034 17.3 0.4 1.4 1 0 0 1 1 1 1 LisH Glt_symporter PF03616.14 ORX67471.1 - 0.047 12.4 1.5 0.081 11.6 1.5 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter FHIPEP PF00771.20 ORX67471.1 - 0.13 10.7 4.6 0.28 9.6 4.6 1.5 1 0 0 1 1 1 0 FHIPEP family Otopetrin PF03189.13 ORX67471.1 - 2.6 6.8 5.6 5.3 5.8 5.6 1.4 1 0 0 1 1 1 0 Otopetrin SID-1_RNA_chan PF13965.6 ORX67471.1 - 2.6 6.3 4.5 4.3 5.6 4.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4471 PF14740.6 ORX67471.1 - 3.1 6.9 9.7 0.25 10.5 4.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) OATP PF03137.20 ORX67471.1 - 3.4 5.8 8.7 0.98 7.6 4.8 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TFB6 PF17110.5 ORX67471.1 - 5.1 6.8 8.0 12 5.6 8.0 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH EMC3_TMCO1 PF01956.16 ORX67471.1 - 5.2 6.8 7.2 15 5.3 7.2 1.7 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Folate_carrier PF01770.18 ORX67471.1 - 5.8 5.5 7.9 9.9 4.8 7.9 1.2 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.8 ORX67471.1 - 9.2 6.2 7.1 1.2 9.0 2.0 2.1 2 0 0 2 2 2 0 N-glycosylation protein CSG2 PF16965.5 ORX67471.1 - 9.4 5.1 7.1 19 4.1 7.1 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator zf-RING_2 PF13639.6 ORX67472.1 - 2.7e-13 50.0 5.8 2.7e-13 50.0 5.8 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ORX67472.1 - 6.8e-12 44.9 2.5 1.8e-11 43.6 2.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX67472.1 - 1.1e-09 37.9 4.2 1.1e-09 37.9 4.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX67472.1 - 4.6e-08 32.8 2.9 9.6e-08 31.8 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX67472.1 - 5.9e-06 26.5 8.1 4.3e-05 23.7 8.1 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX67472.1 - 2.3e-05 24.2 2.4 4.8e-05 23.2 2.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX67472.1 - 3.2e-05 23.8 2.5 5.8e-05 23.0 0.7 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX67472.1 - 0.00021 21.1 2.2 0.00045 20.0 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX67472.1 - 0.0035 17.2 5.2 0.019 14.8 5.4 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX67472.1 - 0.0042 17.1 2.9 0.015 15.3 2.9 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX67472.1 - 0.28 10.9 6.6 0.042 13.5 2.1 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX67472.1 - 0.76 10.0 4.4 1.1 9.5 2.9 2.2 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Pkinase PF00069.25 ORX67473.1 - 2e-43 148.7 0.0 9.9e-43 146.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX67473.1 - 5.6e-10 38.9 0.0 6.8e-08 32.1 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 ORX67473.1 - 4.2e-06 26.9 0.0 0.001 19.1 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX67473.1 - 0.0072 15.1 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX67473.1 - 0.13 11.6 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Oxidored_FMN PF00724.20 ORX67475.1 - 3.8e-72 243.4 0.0 4.5e-72 243.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ORX67475.1 - 0.0052 15.9 0.0 0.24 10.5 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) adh_short PF00106.25 ORX67476.1 - 3e-40 137.8 3.3 3.6e-40 137.5 3.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX67476.1 - 5.7e-28 98.1 4.1 7e-28 97.8 4.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ORX67476.1 - 4.2e-06 26.4 1.2 2.3e-05 24.0 1.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ORX67476.1 - 4.4e-06 26.7 2.3 6.1e-06 26.3 2.3 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ORX67476.1 - 0.0018 17.7 0.2 0.057 12.8 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ORX67476.1 - 0.091 11.8 0.1 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family BK_channel_a PF03493.18 ORX67477.1 - 1.4e-17 63.7 0.0 1.4e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Cytochrom_B561 PF03188.16 ORX67478.1 - 6e-09 36.1 2.3 1.8e-08 34.6 1.5 2.0 1 1 1 2 2 2 2 Eukaryotic cytochrome b561 DUF4079 PF13301.6 ORX67478.1 - 0.00073 19.7 9.6 0.002 18.3 0.4 3.5 2 2 1 4 4 4 2 Protein of unknown function (DUF4079) AzlD PF05437.12 ORX67478.1 - 0.028 14.6 1.9 0.058 13.6 0.3 2.1 1 1 1 2 2 2 0 Branched-chain amino acid transport protein (AzlD) MgtC PF02308.16 ORX67478.1 - 0.33 11.3 7.6 0.16 12.3 4.1 2.3 2 1 0 2 2 2 0 MgtC family CPDase PF07823.11 ORX67479.1 - 2.3e-16 60.1 0.4 1.4e-15 57.6 0.4 1.8 1 1 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 ORX67479.1 - 7.5e-06 25.9 0.4 1.6e-05 24.8 0.4 1.5 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily L27_1 PF09058.10 ORX67479.1 - 0.075 13.0 0.0 0.17 11.9 0.0 1.6 2 0 0 2 2 2 0 L27_1 UCH PF00443.29 ORX67480.1 - 1.4e-22 80.4 0.0 2.2e-21 76.5 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX67480.1 - 1.3e-07 31.6 0.0 5.7e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LSM PF01423.22 ORX67480.1 - 0.00076 19.1 0.1 0.083 12.6 0.0 2.3 1 1 1 2 2 2 2 LSM domain Nop25 PF09805.9 ORX67480.1 - 0.65 10.5 5.5 0.087 13.3 0.6 2.0 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) PAXNEB PF05625.11 ORX67481.1 - 8.5e-54 183.1 0.0 1.1e-53 182.8 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein TauD PF02668.16 ORX67482.1 - 1.9e-22 80.4 1.7 5.1e-21 75.7 1.7 2.1 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RhoGEF PF00621.20 ORX67483.1 - 9.2e-15 55.3 0.0 1.5e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ORX67483.1 - 0.00027 21.4 0.0 0.00045 20.7 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_4 PF15404.6 ORX67483.1 - 0.037 13.8 0.1 0.057 13.2 0.1 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain zf-C3HC4_3 PF13920.6 ORX67484.1 - 7.2e-14 51.4 13.5 7.2e-14 51.4 13.5 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ORX67484.1 - 1.1e-11 44.7 7.3 1.1e-11 44.7 7.3 3.2 2 1 1 3 3 3 1 FYVE zinc finger Prok-RING_4 PF14447.6 ORX67484.1 - 0.00086 19.1 13.9 0.00086 19.1 13.9 3.3 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 Pellino PF04710.14 ORX67484.1 - 0.017 13.8 1.4 0.031 13.0 1.4 1.4 1 0 0 1 1 1 0 Pellino Blt1 PF12754.7 ORX67484.1 - 0.24 11.7 1.7 0.4 11.0 1.7 1.3 1 0 0 1 1 1 0 Blt1 N-terminal domain zf-C3HC4_2 PF13923.6 ORX67484.1 - 0.89 9.4 27.7 0.034 14.0 15.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sec7 PF01369.20 ORX67485.1 - 2.6e-28 98.9 0.0 3.8e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ORX67485.1 - 1.1e-09 38.7 0.0 2.4e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX67485.1 - 3e-07 30.9 0.0 5.1e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 PH domain ABC_tran_CTD PF16326.5 ORX67485.1 - 0.0091 16.2 0.1 0.019 15.2 0.1 1.4 1 0 0 1 1 1 1 ABC transporter C-terminal domain Val_tRNA-synt_C PF10458.9 ORX67485.1 - 0.02 15.2 2.9 0.21 11.9 2.3 2.3 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm XhlA PF10779.9 ORX67485.1 - 0.1 12.8 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Haemolysin XhlA HAUS-augmin3 PF14932.6 ORX67485.1 - 0.1 12.1 0.7 0.15 11.6 0.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 EBP PF05241.12 ORX67486.1 - 1.1e-45 155.3 8.7 1.4e-45 154.9 8.7 1.1 1 0 0 1 1 1 1 Emopamil binding protein 14-3-3 PF00244.20 ORX67487.1 - 1.4e-104 348.4 6.7 1.6e-104 348.2 6.7 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 ORX67487.1 - 0.26 11.6 3.6 2 8.7 0.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4710 PF15828.5 ORX67487.1 - 0.34 11.1 0.1 0.34 11.1 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4710) Sgf11 PF08209.11 ORX67488.1 - 2.4e-11 43.0 1.0 2.4e-11 43.0 1.0 1.7 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) zf-Di19 PF05605.12 ORX67488.1 - 0.28 11.5 3.2 3.2 8.1 0.2 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ORC4_C PF14629.6 ORX67489.1 - 6.2e-43 146.7 0.1 8.9e-43 146.2 0.1 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ORX67489.1 - 1.7e-14 54.5 2.4 2.4e-14 54.1 0.3 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 ORX67489.1 - 5.6e-08 33.3 0.1 1.4e-07 32.0 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX67489.1 - 8.2e-08 32.6 0.0 2.3e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ORX67489.1 - 1.1e-06 28.7 0.1 3.4e-05 23.9 0.0 2.2 1 1 0 2 2 2 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 ORX67489.1 - 2.2e-05 23.7 0.0 4.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ORX67489.1 - 0.0015 18.2 0.0 0.0036 17.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain TniB PF05621.11 ORX67489.1 - 0.005 16.3 0.1 0.033 13.6 0.1 2.3 1 1 0 1 1 1 1 Bacterial TniB protein AAA_7 PF12775.7 ORX67489.1 - 0.0051 16.3 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region SMC_N PF02463.19 ORX67489.1 - 0.0075 15.7 0.0 0.021 14.3 0.0 1.7 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ORX67489.1 - 0.0082 16.1 0.1 0.022 14.7 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 ORX67489.1 - 0.011 15.8 0.0 0.026 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX67489.1 - 0.019 15.1 0.0 0.99 9.6 0.0 2.9 2 1 1 3 3 3 0 AAA domain Mg_chelatase PF01078.21 ORX67489.1 - 0.046 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI GABP-alpha PF11620.8 ORX67489.1 - 0.048 13.9 0.1 0.36 11.1 0.0 2.4 3 0 0 3 3 3 0 GA-binding protein alpha chain Gtr1_RagA PF04670.12 ORX67489.1 - 0.085 12.2 0.1 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 ORX67489.1 - 0.092 13.3 0.0 0.29 11.7 0.0 1.9 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ORX67489.1 - 0.12 12.8 0.0 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase EF-hand_1 PF00036.32 ORX67490.1 - 1.3e-15 55.7 8.5 6.8e-05 22.1 0.1 4.2 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 ORX67490.1 - 7e-15 53.6 6.5 2.3e-05 23.9 0.7 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ORX67490.1 - 3.8e-14 52.3 4.0 6.3e-08 32.3 0.1 3.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 ORX67490.1 - 1e-11 45.1 1.2 1.1e-07 32.2 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_11 PF08976.11 ORX67490.1 - 0.00019 22.3 0.0 0.013 16.3 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 ORX67490.1 - 0.00095 19.1 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_5 PF13202.6 ORX67490.1 - 0.029 13.9 7.1 0.053 13.0 0.1 3.1 3 0 0 3 3 3 0 EF hand DUF853 PF05872.12 ORX67490.1 - 0.05 12.2 0.9 1.3 7.5 0.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) EF-hand_9 PF14658.6 ORX67490.1 - 0.13 12.6 0.0 11 6.4 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain ABC_tran PF00005.27 ORX67491.1 - 1.7e-24 86.9 0.0 1.3e-18 67.8 0.0 3.4 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ORX67491.1 - 3.1e-08 33.4 0.1 0.14 11.6 0.0 3.4 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX67491.1 - 1.3e-06 28.5 0.1 0.017 15.2 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_membrane PF00664.23 ORX67491.1 - 0.00027 20.7 1.0 0.00027 20.7 1.0 3.4 3 1 1 4 4 4 1 ABC transporter transmembrane region AAA_29 PF13555.6 ORX67491.1 - 0.00034 20.3 3.6 0.11 12.2 0.1 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 ORX67491.1 - 0.00068 19.7 1.7 0.0079 16.3 0.1 2.6 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 ORX67491.1 - 0.00078 19.4 1.5 0.15 11.9 0.0 3.1 3 0 0 3 3 3 1 RsgA GTPase AAA_21 PF13304.6 ORX67491.1 - 0.001 19.0 1.1 0.19 11.5 0.1 2.7 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 ORX67491.1 - 0.0055 15.9 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain GTP_EFTU PF00009.27 ORX67491.1 - 0.0074 15.8 0.0 1.1 8.8 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX67491.1 - 0.012 16.0 0.2 0.68 10.3 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 ORX67491.1 - 0.035 14.2 0.5 0.49 10.5 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain Roc PF08477.13 ORX67491.1 - 0.059 13.6 0.4 14 5.9 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ORX67491.1 - 0.14 12.6 2.5 4 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ORX67491.1 - 9.5 6.5 6.8 5.5 7.3 0.2 3.1 3 0 0 3 3 3 0 AAA domain COS PF18568.1 ORX67494.1 - 0.72 9.8 2.1 5 7.2 0.2 2.4 2 0 0 2 2 2 0 TRIM C-terminal subgroup One Signature domain Rad9 PF04139.13 ORX67495.1 - 7.7e-58 195.9 0.0 1.2e-57 195.2 0.0 1.3 1 1 0 1 1 1 1 Rad9 RRP7 PF12923.7 ORX67496.1 - 4.1e-32 110.8 5.6 6.7e-32 110.1 5.6 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 ORX67496.1 - 9.5e-11 41.8 0.0 1.7e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain CCDC71L PF15374.6 ORX67496.1 - 0.025 13.8 0.3 0.029 13.7 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SprB PF13573.6 ORX67496.1 - 1.1 9.0 3.3 6.6 6.6 1.7 2.2 2 0 0 2 2 2 0 SprB repeat AMP-binding PF00501.28 ORX67497.1 - 4.8e-13 48.5 0.1 3.8e-12 45.5 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme GCP_N_terminal PF17681.1 ORX67498.1 - 5.5e-49 167.4 0.0 7.4e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ORX67498.1 - 1.6e-29 103.4 0.3 3.2e-29 102.4 0.3 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Mpp10 PF04006.12 ORX67498.1 - 0.051 12.0 0.0 0.073 11.5 0.0 1.1 1 0 0 1 1 1 0 Mpp10 protein EBP PF05241.12 ORX67499.1 - 9.5e-51 171.8 3.3 1.2e-50 171.5 3.3 1.0 1 0 0 1 1 1 1 Emopamil binding protein DUF2781 PF10914.8 ORX67499.1 - 0.051 14.0 5.1 0.07 13.5 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) Tubulin_3 PF14881.6 ORX67501.1 - 2.1e-26 92.7 0.0 3.4e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 ORX67501.1 - 1.7e-23 83.1 0.1 3.3e-23 82.2 0.1 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 ORX67501.1 - 1.7e-10 41.4 0.0 1.1e-05 25.7 0.0 2.2 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Abhydrolase_3 PF07859.13 ORX67504.1 - 6.1e-47 160.2 0.0 8e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX67504.1 - 3.7e-07 29.4 0.0 6.7e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 ORX67504.1 - 0.00012 22.8 0.2 0.00016 22.4 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX67504.1 - 0.0021 17.4 0.0 0.015 14.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ORX67505.1 - 1.3e-42 146.1 0.0 1.7e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX67505.1 - 1.9e-07 30.3 0.0 2.9e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Thioesterase PF00975.20 ORX67505.1 - 0.0074 16.4 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 ORX67505.1 - 0.064 12.5 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 WD40 PF00400.32 ORX67506.1 - 3.6e-16 59.3 7.1 0.0089 16.9 0.2 7.6 7 0 0 7 7 7 3 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 ORX67506.1 - 1e-09 38.1 10.7 2e-09 37.1 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX67506.1 - 1.8e-08 34.1 7.1 4.8e-08 32.7 7.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX67506.1 - 1.8e-08 34.6 9.6 3.8e-08 33.5 9.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ORX67506.1 - 1e-07 31.7 10.7 2e-07 30.8 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX67506.1 - 2.6e-06 27.4 9.5 6.8e-06 26.0 9.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX67506.1 - 9.2e-06 25.5 10.6 2.7e-05 24.0 10.6 1.9 1 0 0 1 1 1 1 zinc-RING finger domain ANAPC4_WD40 PF12894.7 ORX67506.1 - 1.6e-05 25.1 0.0 7.8 6.9 0.0 5.0 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain zf-rbx1 PF12678.7 ORX67506.1 - 2.8e-05 24.3 5.2 9.9e-05 22.6 5.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ORX67506.1 - 4.1e-05 23.6 9.7 9.4e-05 22.5 9.7 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING WD40_like PF17005.5 ORX67506.1 - 0.0024 17.3 0.0 0.0084 15.5 0.0 1.7 2 0 0 2 2 2 1 WD40-like domain Prok-RING_4 PF14447.6 ORX67506.1 - 0.0029 17.4 7.5 0.025 14.4 8.1 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 ORX67506.1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 U-box domain Rad50_zn_hook PF04423.14 ORX67506.1 - 0.039 13.8 1.0 43 4.1 0.2 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif zinc-ribbons_6 PF07191.12 ORX67506.1 - 0.085 12.8 5.7 0.18 11.8 5.7 1.5 1 0 0 1 1 1 0 zinc-ribbons zf-ANAPC11 PF12861.7 ORX67506.1 - 0.4 10.8 4.0 1.2 9.2 4.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ORX67506.1 - 0.49 10.2 10.8 0.093 12.5 6.6 2.0 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 ORX67506.1 - 1.1 9.2 8.4 3.6 7.5 8.6 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 ORX67506.1 - 1.1 9.3 4.9 2.7 8.1 4.9 1.6 1 0 0 1 1 1 0 Double zinc ribbon DUF3325 PF11804.8 ORX67507.1 - 2.7 8.2 9.2 0.79 9.9 4.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3325) Myb_DNA-binding PF00249.31 ORX67508.1 - 6.9e-14 51.8 2.6 1.2e-13 51.0 2.6 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX67508.1 - 4.3e-09 36.5 1.1 8.7e-09 35.5 1.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Na_Ca_ex PF01699.24 ORX67510.1 - 8.5e-16 58.3 12.5 1.3e-15 57.7 12.5 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Nsp1_C PF05064.13 ORX67511.1 - 1.3e-29 102.4 1.9 2.5e-29 101.4 0.3 2.1 1 1 1 2 2 2 1 Nsp1-like C-terminal region Syntaxin-6_N PF09177.11 ORX67511.1 - 0.15 12.6 1.9 0.75 10.4 1.0 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal AAA_13 PF13166.6 ORX67511.1 - 0.2 10.2 0.9 0.27 9.8 0.9 1.3 1 0 0 1 1 1 0 AAA domain NPV_P10 PF05531.12 ORX67511.1 - 0.83 10.2 4.7 24 5.5 0.0 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein F-box-like PF12937.7 ORX67512.1 - 0.016 15.1 0.8 0.094 12.6 0.1 2.4 2 1 0 2 2 2 0 F-box-like DUF1561 PF07598.11 ORX67514.1 - 0.011 14.0 0.6 0.014 13.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1561) DUF962 PF06127.11 ORX67515.1 - 6.3e-29 99.9 0.0 1e-28 99.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Ribophorin_II PF05817.14 ORX67515.1 - 0.053 12.1 0.3 0.078 11.5 0.3 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Ribosomal_S24e PF01282.19 ORX67516.1 - 6.1e-36 122.2 0.9 1.4e-35 121.1 0.0 1.8 1 1 1 2 2 2 1 Ribosomal protein S24e PCRF PF03462.18 ORX67517.1 - 3.3e-41 141.3 1.0 1.4e-40 139.2 0.0 2.0 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 ORX67517.1 - 1.2e-38 131.6 3.2 2.2e-38 130.8 3.2 1.4 1 0 0 1 1 1 1 RF-1 domain Spc7_C2 PF15577.6 ORX67517.1 - 0.046 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Spc7_C2 EamA PF00892.20 ORX67518.1 - 4.3e-11 43.1 24.5 2.3e-05 24.6 9.5 2.8 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ORX67518.1 - 1e-06 28.2 9.4 2.1e-06 27.2 9.4 1.5 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 ORX67518.1 - 5.6e-06 25.7 0.2 5.6e-06 25.7 0.2 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.16 ORX67518.1 - 2.5e-05 23.8 9.8 0.00037 19.9 1.5 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family PUNUT PF16913.5 ORX67518.1 - 0.0004 19.7 0.9 0.0004 19.7 0.9 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport CRT-like PF08627.10 ORX67518.1 - 0.0053 15.8 2.6 0.0053 15.8 2.6 2.7 3 0 0 3 3 3 2 CRT-like, chloroquine-resistance transporter-like 7TMR-DISM_7TM PF07695.11 ORX67518.1 - 0.83 9.5 25.9 0.11 12.3 5.1 3.5 3 0 0 3 3 3 0 7TM diverse intracellular signalling EamA PF00892.20 ORX67519.1 - 0.23 11.6 17.8 0.4 10.9 1.4 2.8 3 1 0 3 3 3 0 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX67520.1 - 3.8e-06 26.3 0.1 6.6e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 ORX67520.1 - 0.00013 21.3 1.0 0.00027 20.3 1.0 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX67520.1 - 0.0013 18.9 3.8 0.0013 18.9 3.8 3.0 3 1 0 3 3 3 1 EamA-like transporter family Mg_trans_NIPA PF05653.14 ORX67520.1 - 0.022 13.9 0.6 0.022 13.9 0.6 2.1 1 1 0 2 2 2 0 Magnesium transporter NIPA UAA PF08449.11 ORX67521.1 - 2.2e-08 33.6 9.7 3e-08 33.2 9.7 1.2 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 ORX67521.1 - 1.2e-07 31.2 0.2 2.2e-07 30.4 0.2 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ORX67521.1 - 4e-05 23.8 4.8 4e-05 23.8 4.8 2.4 2 0 0 2 2 2 1 EamA-like transporter family CRT-like PF08627.10 ORX67521.1 - 0.038 13.0 10.0 0.036 13.0 4.8 2.2 1 1 1 2 2 2 0 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 ORX67521.1 - 0.5 9.7 8.5 3 7.1 8.5 1.9 1 1 0 1 1 1 0 Triose-phosphate Transporter family NFACT-R_1 PF05670.13 ORX67522.1 - 8.1e-32 110.1 0.2 2.4e-31 108.6 0.0 1.9 2 0 0 2 2 2 1 NFACT protein RNA binding domain NFACT-C PF11923.8 ORX67522.1 - 1.1e-29 102.5 0.1 1.1e-29 102.5 0.1 2.7 2 0 0 2 2 2 1 NFACT protein C-terminal domain FbpA PF05833.11 ORX67522.1 - 4.1e-28 98.3 4.4 7.5e-28 97.5 0.1 2.5 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) Endostatin PF06482.11 ORX67522.1 - 0.77 9.2 5.1 34 3.7 0.0 2.7 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin LCD1 PF09798.9 ORX67522.1 - 4.9 5.6 10.0 8.9 4.7 10.0 1.3 1 0 0 1 1 1 0 DNA damage checkpoint protein Methyltransf_11 PF08241.12 ORX67523.1 - 9.1e-11 42.3 0.0 1.9e-10 41.2 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX67523.1 - 4.4e-09 36.9 0.0 1.1e-08 35.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX67523.1 - 1.9e-05 24.5 0.0 3.6e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX67523.1 - 3.7e-05 23.6 0.0 4.9e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX67523.1 - 0.0045 16.3 0.2 0.039 13.3 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX67523.1 - 0.013 16.2 0.0 0.025 15.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 ORX67523.1 - 0.017 14.0 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Transferase PF02458.15 ORX67524.1 - 1.1e-08 34.2 0.0 0.00092 18.0 0.0 2.5 3 0 0 3 3 3 2 Transferase family XRN_M PF17846.1 ORX67525.1 - 7.4e-15 54.8 4.8 3.3e-10 39.5 0.1 2.1 2 0 0 2 2 2 2 Xrn1 helical domain XRN_N PF03159.18 ORX67525.1 - 2.6e-11 43.4 0.0 6.2e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus TPK_B1_binding PF04265.14 ORX67525.1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain Ank_4 PF13637.6 ORX67526.1 - 1.3e-14 54.3 0.3 2.7e-09 37.4 0.0 3.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX67526.1 - 5e-14 52.2 0.5 5.1e-10 39.4 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX67526.1 - 2.7e-13 50.3 0.0 8.4e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX67526.1 - 4e-13 49.2 0.7 1.3e-08 34.9 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 ORX67526.1 - 2.1e-11 43.0 0.0 1.1e-06 28.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Med9 PF07544.13 ORX67526.1 - 0.048 13.7 0.0 0.048 13.7 0.0 3.3 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Acetyltransf_11 PF13720.6 ORX67526.1 - 1.1 9.8 3.5 2.4 8.7 0.0 3.2 2 1 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TFIIA PF03153.13 ORX67526.1 - 1.4 8.8 37.0 0.29 11.1 31.6 2.2 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pyr_redox_2 PF07992.14 ORX67527.1 - 9.2e-08 31.7 2.2 8.2e-06 25.3 0.0 2.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX67527.1 - 1.8e-05 24.1 0.0 0.0013 18.1 0.0 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_9 PF13454.6 ORX67527.1 - 0.0019 18.2 0.0 0.0041 17.1 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ORX67527.1 - 0.0074 16.5 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ORX67527.1 - 0.13 12.9 0.0 2.9 8.5 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX67527.1 - 0.2 10.3 0.0 0.41 9.3 0.0 1.5 1 0 0 1 1 1 0 HI0933-like protein UPF0020 PF01170.18 ORX67529.1 - 1.5e-12 47.6 0.0 8e-12 45.3 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 ORX67529.1 - 2.1e-05 24.0 0.0 3.1e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.18 ORX67529.1 - 0.0074 16.0 0.0 0.52 10.0 0.0 2.5 2 0 0 2 2 2 1 DNA methylase DUF43 PF01861.16 ORX67529.1 - 0.062 12.5 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain GNAT_acetyltr_2 PF13718.6 ORX67530.1 - 4.1e-92 307.7 0.1 1.4e-91 305.9 0.0 2.0 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 ORX67530.1 - 2.6e-85 285.9 0.5 4.8e-85 285.0 0.5 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 ORX67530.1 - 1.6e-63 213.8 0.0 6.3e-63 211.8 0.0 2.0 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 ORX67530.1 - 5e-34 116.1 0.1 1.7e-33 114.4 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 ORX67530.1 - 0.00012 21.8 1.2 0.03 14.0 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ORX67530.1 - 0.14 12.4 0.0 3.1 8.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain HisKA PF00512.25 ORX67531.1 - 0.014 15.4 0.2 0.031 14.3 0.2 1.5 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain SspB PF04386.13 ORX67531.1 - 0.14 12.0 0.1 0.22 11.4 0.1 1.4 1 1 0 1 1 1 0 Stringent starvation protein B IMCp PF12314.8 ORX67532.1 - 0.028 14.7 0.0 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 Inner membrane complex protein NTP_transferase PF00483.23 ORX67533.1 - 1.7e-53 181.8 0.0 2.1e-53 181.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ORX67533.1 - 4.4e-12 45.2 8.1 7.2e-10 38.2 2.6 3.8 1 1 3 4 4 4 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX67533.1 - 3.6e-10 40.4 0.0 5.4e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 ORX67533.1 - 8.7e-05 22.2 5.8 0.00051 19.7 1.5 3.2 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.19 ORX67533.1 - 0.0066 16.4 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 Cytidylyltransferase DUF4954 PF16314.5 ORX67533.1 - 0.029 12.5 0.5 0.087 10.9 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ORX67533.1 - 0.069 12.1 0.2 0.12 11.2 0.2 1.4 1 0 0 1 1 1 0 L-fucokinase IspD PF01128.19 ORX67533.1 - 0.11 12.2 0.1 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Nipped-B_C PF12830.7 ORX67535.1 - 2.4e-27 96.1 4.8 4.3e-26 92.0 0.8 4.1 3 1 0 3 3 3 1 Sister chromatid cohesion C-terminus HEAT PF02985.22 ORX67535.1 - 0.00089 19.3 2.1 49 4.6 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat Gcn1_N PF12074.8 ORX67535.1 - 0.0021 17.4 0.1 15 4.8 0.0 4.2 3 1 1 4 4 4 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal TetR_C_15 PF17918.1 ORX67535.1 - 0.028 15.2 0.4 0.92 10.3 0.2 3.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HEAT_EZ PF13513.6 ORX67535.1 - 0.28 11.7 4.7 54 4.4 0.1 5.2 5 1 0 6 6 6 0 HEAT-like repeat Cohesin_HEAT PF12765.7 ORX67535.1 - 0.8 10.1 6.1 0.16 12.3 0.2 3.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Asp PF00026.23 ORX67537.1 - 5.9e-79 265.7 0.0 6.6e-79 265.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX67537.1 - 1.2e-11 45.2 1.3 1.2e-09 38.7 1.0 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX67537.1 - 0.094 13.4 0.3 5.6 7.7 0.1 2.9 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 ORX67537.1 - 0.11 13.0 0.2 28 5.4 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Fasciclin PF02469.22 ORX67539.1 - 6.4e-27 94.3 0.0 5.7e-08 33.0 0.0 5.8 5 1 0 5 5 5 4 Fasciclin domain Hist_deacetyl PF00850.19 ORX67540.1 - 2.9e-83 279.9 0.2 5.9e-83 278.9 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain ELO PF01151.18 ORX67541.1 - 6.9e-39 133.9 7.6 7.4e-38 130.5 7.6 2.1 1 1 0 1 1 1 1 GNS1/SUR4 family NMD3 PF04981.13 ORX67543.1 - 1.3e-64 218.0 9.6 3.5e-62 210.0 9.6 2.1 1 1 0 1 1 1 1 NMD3 family DZR PF12773.7 ORX67543.1 - 0.034 14.2 4.0 3.7 7.6 2.5 2.7 1 1 1 2 2 2 0 Double zinc ribbon TackOD1 PF18551.1 ORX67543.1 - 0.45 10.2 2.8 0.99 9.0 0.6 2.2 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 Sgf11 PF08209.11 ORX67543.1 - 3.6 7.2 7.3 39 3.9 0.1 3.3 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) PH PF00169.29 ORX67544.1 - 0.0086 16.6 0.0 0.015 15.8 0.0 1.4 1 0 0 1 1 1 1 PH domain Sacchrp_dh_C PF16653.5 ORX67545.1 - 2.4e-91 306.5 0.0 3.5e-91 306.0 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ORX67545.1 - 4.5e-26 91.6 0.2 6.6e-26 91.1 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ORX67545.1 - 1.1e-06 28.8 0.0 1.8e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 ORX67545.1 - 2.3e-06 27.6 0.1 3.7e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 ORX67545.1 - 0.00048 20.7 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 ORX67545.1 - 0.00055 20.8 0.1 0.0015 19.3 0.1 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ORX67545.1 - 0.012 16.2 0.1 0.021 15.5 0.1 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ORX67545.1 - 0.084 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_7 PF13241.6 ORX67545.1 - 0.18 12.3 0.1 0.3 11.5 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF974 PF06159.13 ORX67546.1 - 5.3e-61 206.5 0.2 8.8e-61 205.8 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF974) Trs65 PF12735.7 ORX67546.1 - 7.7e-09 35.4 3.5 6.3e-05 22.5 0.2 3.2 3 1 0 3 3 3 2 TRAPP trafficking subunit Trs65 Gryzun-like PF12742.7 ORX67546.1 - 8.6e-05 22.5 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Transglut_C PF00927.22 ORX67546.1 - 0.017 15.3 1.1 0.53 10.4 0.0 3.0 3 0 0 3 3 3 0 Transglutaminase family, C-terminal ig like domain Arrestin_C PF02752.22 ORX67546.1 - 0.022 15.2 0.2 0.048 14.1 0.1 1.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Putative_PNPOx PF01243.20 ORX67547.1 - 1.9e-07 31.2 0.0 3.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase MBOAT PF03062.19 ORX67548.1 - 8.4e-07 28.7 8.6 0.00013 21.5 1.9 2.1 1 1 1 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family DUF3772 PF12607.8 ORX67549.1 - 0.069 12.9 0.2 0.16 11.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Glyco_hydro_16 PF00722.21 ORX67550.1 - 2.8e-23 82.3 8.5 2.5e-22 79.2 8.5 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 CENP-U PF13097.6 ORX67550.1 - 0.72 9.8 6.2 1.1 9.2 6.2 1.2 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit ELO PF01151.18 ORX67552.1 - 3.4e-37 128.3 11.2 7.6e-28 97.7 3.2 2.0 1 1 1 2 2 2 2 GNS1/SUR4 family zf-C2H2 PF00096.26 ORX67553.1 - 3.8e-12 45.9 13.7 7.5e-06 26.1 3.0 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX67553.1 - 3.4e-09 36.7 21.8 1.7e-05 25.0 4.3 3.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX67553.1 - 4.1e-08 33.4 11.0 0.00058 20.5 1.7 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX67553.1 - 0.0018 18.5 0.6 0.77 10.1 0.1 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX67553.1 - 0.003 17.5 0.4 0.33 11.0 0.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger FOXP-CC PF16159.5 ORX67553.1 - 0.0057 17.3 1.6 0.022 15.4 0.1 1.9 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 ORX67553.1 - 0.01 15.6 12.8 0.18 11.6 0.3 3.3 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 ORX67553.1 - 0.039 14.3 4.2 0.049 13.9 4.2 1.2 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 ORX67553.1 - 0.77 10.3 9.7 8 7.0 0.0 2.8 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain YjeF_N PF03853.15 ORX67554.1 - 8.6e-29 100.6 0.0 1.2e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus zf-C2H2 PF00096.26 ORX67555.1 - 1.5e-12 47.2 15.5 2.8e-06 27.5 4.7 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX67555.1 - 9.6e-10 38.4 20.5 3.6e-05 24.0 6.4 3.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX67555.1 - 1.6e-07 31.5 12.9 0.0014 19.3 3.3 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX67555.1 - 0.0085 15.8 1.8 0.0085 15.8 1.8 1.8 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 ORX67555.1 - 0.015 15.0 12.8 0.22 11.3 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain GAGA PF09237.11 ORX67555.1 - 0.02 14.7 2.7 0.14 12.0 0.2 2.1 1 1 1 2 2 2 0 GAGA factor FOXP-CC PF16159.5 ORX67555.1 - 0.083 13.5 3.5 0.094 13.4 0.4 2.0 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX67555.1 - 0.087 13.1 1.0 0.52 10.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-C2H2_12 PF18112.1 ORX67555.1 - 5 7.7 10.1 31 5.1 0.0 2.8 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain SRP_TPR_like PF17004.5 ORX67556.1 - 2.1e-12 47.1 9.1 1.2e-10 41.4 7.1 2.5 2 0 0 2 2 2 1 Putative TPR-like repeat TPR_2 PF07719.17 ORX67556.1 - 2.3e-12 46.0 17.4 0.062 13.4 0.1 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 ORX67556.1 - 2.1e-10 41.0 37.0 0.0043 17.5 0.1 8.4 4 3 4 8 8 8 5 Tetratricopeptide repeat SRP72 PF08492.12 ORX67556.1 - 2.5e-10 40.6 14.6 2.5e-10 40.6 14.6 2.1 2 0 0 2 2 1 1 SRP72 RNA-binding domain TPR_4 PF07721.14 ORX67556.1 - 7.6e-07 29.2 17.3 0.46 11.3 0.4 7.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX67556.1 - 2.6e-06 27.6 25.1 0.81 10.0 0.2 6.9 4 2 4 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX67556.1 - 5.7e-06 26.1 10.0 0.41 11.0 0.1 6.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX67556.1 - 7.8e-06 25.5 10.8 3.7 7.5 0.2 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX67556.1 - 2.6e-05 24.6 26.8 6 8.0 0.1 9.0 6 3 3 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX67556.1 - 0.00014 22.3 25.7 0.092 13.4 0.0 7.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67556.1 - 0.00015 22.4 36.9 0.038 14.6 0.0 8.3 5 3 1 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX67556.1 - 0.00029 21.0 22.1 0.019 15.2 7.6 5.1 5 1 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ORX67556.1 - 0.51 10.3 9.1 32 4.6 0.1 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat NAD_binding_6 PF08030.12 ORX67557.1 - 2e-16 60.5 0.0 7.8e-14 52.1 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX67557.1 - 8.5e-15 54.8 0.0 4.8e-14 52.4 0.0 2.1 1 1 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ORX67557.1 - 1.3e-14 54.4 11.3 1.3e-14 54.4 11.3 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX67557.1 - 0.0032 18.1 0.0 0.069 13.8 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 ORX67558.1 - 1.7e-14 53.8 0.1 9.7e-14 51.4 0.0 2.0 1 1 1 2 2 2 1 FAD-binding domain MFS_1 PF07690.16 ORX67559.1 - 1.1e-36 126.5 10.0 1.3e-36 126.3 10.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX67559.1 - 1.1e-10 40.9 4.5 1.5e-10 40.5 4.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 ORX67559.1 - 4.9e-06 25.4 1.4 5.8e-06 25.1 1.4 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 ORX67559.1 - 4.3e-05 22.5 3.0 5.4e-05 22.2 3.0 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 ORX67559.1 - 0.00024 20.5 0.7 0.00033 20.1 0.7 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 ORX67559.1 - 0.0021 16.6 1.7 0.0026 16.3 1.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ORX67559.1 - 0.015 13.7 2.6 0.019 13.4 2.6 1.0 1 0 0 1 1 1 0 Transmembrane secretion effector PTR2 PF00854.21 ORX67559.1 - 0.041 12.7 2.4 0.52 9.1 0.1 2.1 1 1 1 2 2 2 0 POT family OATP PF03137.20 ORX67559.1 - 0.072 11.4 4.7 0.26 9.5 4.7 1.7 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Bacteriocin_IIc PF10439.9 ORX67559.1 - 2.1 8.5 6.6 5.4 7.2 6.6 1.7 1 1 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide MFS_1 PF07690.16 ORX67560.1 - 7.7e-48 163.2 29.5 7.7e-48 163.2 29.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SUI1 PF01253.22 ORX67561.1 - 2e-17 63.5 0.6 4.8e-17 62.3 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 ORX67561.1 - 3.4e-14 53.3 0.0 1.2e-13 51.6 0.0 2.0 1 0 0 1 1 1 1 Pre-PUA-like domain SWIB PF02201.18 ORX67561.1 - 3.9e-06 26.6 0.0 1.3e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 SWIB/MDM2 domain PUA PF01472.20 ORX67561.1 - 9.2e-06 25.5 0.2 0.0001 22.2 0.2 2.4 2 0 0 2 2 2 1 PUA domain ABC2_membrane PF01061.24 ORX67562.1 - 3e-19 69.3 16.6 1.2e-16 60.8 16.6 2.9 1 1 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ORX67562.1 - 1.6e-07 32.0 0.0 2.9e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX67562.1 - 0.032 14.0 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RRM_7 PF16367.5 ORX67562.1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif DUF3481 PF11980.8 ORX67562.1 - 0.3 10.8 0.8 0.75 9.5 0.0 1.9 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein Glyco_hydro_16 PF00722.21 ORX67563.1 - 2.3e-28 98.9 0.5 4.3e-28 98.0 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF1080 PF06439.11 ORX67563.1 - 0.018 15.2 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) ABC_ATPase PF09818.9 ORX67564.1 - 3.2e-137 458.0 0.0 4.2e-137 457.6 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 ORX67564.1 - 0.0033 17.9 0.0 0.0055 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ORX67564.1 - 0.13 12.1 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Lipase_GDSL PF00657.22 ORX67565.1 - 7.7e-13 48.9 0.1 1.5e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX67565.1 - 5.5e-08 33.4 0.1 1.6e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family DUF2999 PF11212.8 ORX67565.1 - 0.1 12.9 0.4 0.9 9.9 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2999) DUF515 PF04415.12 ORX67567.1 - 1.3 7.3 2.2 1.6 7.0 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Myb_DNA-binding PF00249.31 ORX67568.1 - 7e-05 22.9 0.2 0.00012 22.2 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SUN PF03856.13 ORX67569.1 - 1.2e-60 205.0 16.4 1.4e-60 204.8 16.4 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) MFS_1 PF07690.16 ORX67570.1 - 4.3e-54 183.8 21.2 4.3e-54 183.8 21.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX67570.1 - 2.2e-15 56.5 3.2 2.2e-15 56.5 3.2 3.5 3 1 0 3 3 3 2 Sugar (and other) transporter MFS_2 PF13347.6 ORX67570.1 - 0.00025 19.7 14.8 0.00026 19.7 1.0 3.0 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_1 PF07690.16 ORX67572.1 - 1.6e-51 175.3 51.5 2.4e-50 171.5 28.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX67572.1 - 9.8e-18 64.2 1.7 9.8e-18 64.2 1.7 3.1 3 1 1 4 4 4 2 Sugar (and other) transporter MFS_2 PF13347.6 ORX67572.1 - 1.7e-05 23.6 1.9 1.7e-05 23.6 1.9 3.2 2 2 1 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.13 ORX67572.1 - 2.7e-05 22.8 4.0 2.7e-05 22.8 4.0 1.8 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 ORX67572.1 - 0.00045 19.6 3.9 0.00045 19.6 3.9 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Iso_dh PF00180.20 ORX67573.1 - 7.3e-67 226.0 0.0 8.8e-67 225.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase S-methyl_trans PF02574.16 ORX67574.1 - 5.4e-63 213.3 0.0 6.1e-63 213.1 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase GST_N_2 PF13409.6 ORX67576.1 - 1.1e-23 83.2 0.0 2.5e-23 82.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX67576.1 - 2.9e-10 40.0 0.0 6.5e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX67576.1 - 6.9e-07 29.4 0.0 1.1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX67576.1 - 1.4e-05 25.4 0.1 0.00013 22.3 0.1 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX67576.1 - 0.00038 20.6 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TatD_DNase PF01026.21 ORX67577.1 - 1.7e-42 145.6 0.0 2.1e-42 145.3 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase DUF4895 PF16236.5 ORX67577.1 - 0.025 14.3 0.0 0.033 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4895) LRR_4 PF12799.7 ORX67578.1 - 0.87 10.1 3.5 11 6.6 0.1 3.1 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX67580.1 - 6.6e-08 32.2 0.2 1.8e-07 30.9 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX67580.1 - 2.4e-07 30.5 0.3 7.5e-07 29.0 0.3 1.9 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.17 ORX67580.1 - 1.5e-05 24.7 6.6 0.74 10.1 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX67580.1 - 0.00027 20.6 1.4 0.83 9.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX67580.1 - 0.0012 19.0 3.0 0.0028 17.8 3.0 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 LRR_6 PF13516.6 ORX67580.1 - 0.0085 16.1 0.2 17 5.8 0.0 4.7 4 0 0 4 4 4 0 Leucine Rich repeat TPR_19 PF14559.6 ORX67580.1 - 0.0094 16.4 10.4 0.036 14.6 1.7 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat LRR_1 PF00560.33 ORX67580.1 - 0.023 15.2 0.2 1e+02 4.0 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich Repeat TPR_17 PF13431.6 ORX67580.1 - 0.091 13.2 1.4 0.18 12.3 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX67580.1 - 0.18 11.5 1.3 0.93 9.2 0.1 2.5 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.6 ORX67580.1 - 0.58 10.8 18.0 0.052 14.2 5.5 3.4 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX67580.1 - 0.68 10.9 13.6 1.4 9.9 0.7 4.2 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 ORX67580.1 - 3.5 8.5 6.7 0.63 10.8 0.8 3.2 2 0 0 2 2 1 0 Tetratricopeptide repeat DEAD PF00270.29 ORX67581.1 - 1.1e-22 80.6 0.0 2.9e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX67581.1 - 1.4e-19 70.5 0.0 1.6e-17 63.8 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RQC PF09382.10 ORX67581.1 - 3.8e-19 68.6 0.3 8.2e-19 67.5 0.3 1.6 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 ORX67581.1 - 2.9e-16 60.0 4.8 1e-15 58.2 4.8 2.1 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 ORX67581.1 - 0.00019 21.5 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ost5 PF05251.12 ORX67582.1 - 6e-13 48.9 2.0 7.4e-13 48.6 2.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Ycf66_N PF07444.11 ORX67582.1 - 0.017 15.2 0.3 0.022 14.9 0.2 1.3 1 1 0 1 1 1 0 Ycf66 protein N-terminus Myb_DNA-binding PF00249.31 ORX67583.1 - 8.9e-46 153.9 7.3 3.1e-14 52.9 0.0 3.0 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX67583.1 - 9.4e-36 121.9 0.2 1.5e-13 50.7 0.0 3.0 1 1 2 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 ORX67583.1 - 3.2e-11 43.2 0.0 0.016 15.3 0.0 3.1 1 1 2 3 3 3 3 SLIDE Rap1_C PF11626.8 ORX67583.1 - 0.0015 18.6 0.0 1 9.5 0.0 3.0 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_7 PF15963.5 ORX67583.1 - 0.0016 18.3 0.0 6.8 6.7 0.0 3.0 2 1 1 3 3 3 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 ORX67583.1 - 0.022 14.9 0.4 2.9 8.1 0.0 2.9 1 1 2 3 3 3 0 SANT/Myb-like domain of DAMP1 Exo70 PF03081.15 ORX67583.1 - 0.19 10.7 0.1 0.23 10.5 0.1 1.4 1 1 0 1 1 1 0 Exo70 exocyst complex subunit Myb_DNA-bind_4 PF13837.6 ORX67583.1 - 0.41 11.1 9.5 29 5.1 0.3 4.6 3 3 0 3 3 3 0 Myb/SANT-like DNA-binding domain COX4 PF02936.14 ORX67585.1 - 0.04 14.0 0.1 0.058 13.4 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV DUF533 PF04391.12 ORX67585.1 - 0.09 12.4 0.1 0.12 11.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Mcl1_mid PF12341.8 ORX67586.1 - 3.3e-80 269.6 0.0 5e-78 262.5 0.0 3.0 2 1 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 ORX67586.1 - 2.3e-20 72.5 15.6 1.3e-09 38.5 0.2 8.0 8 1 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67586.1 - 2.8e-17 62.8 0.3 2.4e-07 31.0 0.0 6.4 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_alpha_N PF12254.8 ORX67586.1 - 0.0049 16.9 0.6 0.011 15.8 0.6 1.5 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Nbas_N PF15492.6 ORX67586.1 - 0.011 15.1 0.2 0.19 11.0 0.0 2.6 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ORX67586.1 - 0.029 14.3 0.5 4 7.5 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ORX67586.1 - 0.052 12.1 0.2 2.7 6.4 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ORX67586.1 - 0.093 11.7 0.0 21 4.0 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DEAD PF00270.29 ORX67587.1 - 3.5e-43 147.4 0.1 1.1e-42 145.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX67587.1 - 1.8e-28 99.1 0.0 6e-25 87.7 0.0 3.4 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ORX67587.1 - 0.01 15.8 0.0 0.033 14.2 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX67587.1 - 0.064 13.5 0.2 0.58 10.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Velvet PF11754.8 ORX67588.1 - 1.1e-51 176.2 2.1 9.7e-26 91.2 1.1 3.0 1 1 1 2 2 2 2 Velvet factor tRNA-synt_1 PF00133.22 ORX67589.1 - 9.1e-126 420.5 0.8 8.5e-71 239.0 0.0 4.0 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ORX67589.1 - 3.5e-16 59.0 2.4 4.1e-07 29.1 0.0 4.3 3 1 1 4 4 4 4 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ORX67589.1 - 9.5e-11 41.9 0.0 3.1e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ORX67589.1 - 0.0081 15.5 0.0 0.64 9.3 0.0 2.5 2 1 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1b PF00579.25 ORX67589.1 - 0.011 15.1 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Val_tRNA-synt_C PF10458.9 ORX67589.1 - 2.5 8.5 6.0 0.62 10.4 0.6 2.3 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Oxidored_q6 PF01058.22 ORX67590.1 - 1.9e-22 79.5 0.2 2.3e-22 79.2 0.2 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit PHD PF00628.29 ORX67591.1 - 2.1e-05 24.3 6.7 2.1e-05 24.3 6.7 3.3 4 0 0 4 4 4 1 PHD-finger C1_1 PF00130.22 ORX67591.1 - 0.0014 18.4 1.1 0.0014 18.4 1.1 3.5 4 0 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 ORX67591.1 - 0.047 13.8 1.1 0.047 13.8 1.1 2.9 4 0 0 4 4 4 0 KIAA1045 RING finger COX6A PF02046.15 ORX67592.1 - 1.6e-14 54.3 2.2 9.7e-13 48.6 2.2 2.0 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa PPR PF01535.20 ORX67593.1 - 2.4e-06 27.4 3.7 1.7 9.1 0.0 6.0 6 0 0 6 6 6 2 PPR repeat TPR_2 PF07719.17 ORX67593.1 - 0.022 14.8 0.3 23 5.4 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 ORX67593.1 - 0.036 14.3 0.8 9.5 6.5 0.0 4.6 6 0 0 6 6 6 0 PPR repeat family TPR_6 PF13174.6 ORX67593.1 - 0.092 13.4 0.7 65 4.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PHP PF02811.19 ORX67594.1 - 2.3e-10 41.0 0.0 3.1e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 PHP domain PHP_C PF13263.6 ORX67594.1 - 0.0097 15.6 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 PHP-associated UPF0180 PF03698.13 ORX67594.1 - 0.12 12.5 0.1 0.77 10.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Chitin_synth_2 PF03142.15 ORX67595.1 - 0.016 13.8 0.1 0.017 13.7 0.1 1.1 1 0 0 1 1 1 0 Chitin synthase DUF2062 PF09835.9 ORX67595.1 - 0.054 13.3 0.2 0.057 13.3 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) EF_assoc_1 PF08355.12 ORX67595.1 - 0.068 12.8 0.1 0.081 12.5 0.1 1.1 1 0 0 1 1 1 0 EF hand associated Aa_trans PF01490.18 ORX67596.1 - 1e-35 123.3 6.0 1.5e-35 122.7 6.0 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF202 PF02656.15 ORX67596.1 - 0.26 11.8 7.4 0.75 10.3 1.7 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF202) QCR10 PF09796.9 ORX67596.1 - 0.45 10.6 1.7 5.8 7.0 0.0 2.9 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) SMYLE_N PF18615.1 ORX67596.1 - 0.76 9.3 2.9 1.1 8.8 2.9 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Dabb PF07876.12 ORX67597.1 - 5.5e-18 65.4 0.1 6e-18 65.3 0.1 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Amdase PF17645.1 ORX67597.1 - 0.0076 15.9 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 Arylmalonate decarboxylase Rad51 PF08423.11 ORX67598.1 - 1.8e-17 63.5 0.0 2.5e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 CP2 PF04516.15 ORX67599.1 - 4.6e-50 170.1 0.0 9.4e-50 169.0 0.0 1.5 1 0 0 1 1 1 1 CP2 transcription factor RRM_1 PF00076.22 ORX67601.1 - 1.3e-35 121.0 0.0 2.4e-18 65.7 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX67601.1 - 2.7e-07 30.6 0.0 5.1e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ORX67601.1 - 0.0031 17.1 0.0 0.014 14.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX67601.1 - 0.087 12.9 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 NifU_N PF01592.16 ORX67602.1 - 7.5e-55 184.5 0.0 9e-55 184.3 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain Det1 PF09737.9 ORX67605.1 - 2e-58 198.5 0.0 7.3e-38 130.7 0.0 2.1 2 0 0 2 2 2 2 De-etiolated protein 1 Det1 DMT_YdcZ PF04657.13 ORX67606.1 - 1.5e-29 103.1 13.5 1.8e-29 102.8 13.5 1.1 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ Pox_A14 PF05767.12 ORX67606.1 - 0.74 10.0 8.5 0.37 11.0 0.9 2.5 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 Smim3 PF17307.2 ORX67606.1 - 1.9 8.0 6.7 0.54 9.8 2.5 2.1 2 0 0 2 2 2 0 Small integral membrane protein 3 Aldedh PF00171.22 ORX67607.1 - 3.9e-116 388.3 0.1 4.8e-116 388.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Importin_rep_4 PF18808.1 ORX67608.1 - 3.9e-39 132.8 9.4 8.6e-36 122.1 0.1 5.1 6 0 0 6 6 4 2 Importin repeat HEAT_2 PF13646.6 ORX67608.1 - 4.9e-19 68.5 15.8 6.1e-05 23.3 0.0 9.6 6 3 3 9 9 9 5 HEAT repeats HEAT PF02985.22 ORX67608.1 - 2.6e-18 64.5 15.6 8e-05 22.6 0.0 11.0 12 0 0 12 12 10 4 HEAT repeat Importin_rep_6 PF18829.1 ORX67608.1 - 3.2e-16 59.4 4.0 3.5e-16 59.3 1.9 2.3 2 0 0 2 2 1 1 Importin repeat 6 HEAT_EZ PF13513.6 ORX67608.1 - 5.8e-16 58.6 22.7 6.3e-08 33.0 0.0 10.0 8 2 4 12 12 11 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ORX67608.1 - 1.7e-09 38.1 3.0 0.00093 19.7 0.0 6.3 6 1 2 8 8 7 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 ORX67608.1 - 3.1e-09 36.9 0.1 0.0023 17.7 0.0 4.3 3 1 1 4 4 4 2 rRNA processing/ribosome biogenesis Adaptin_N PF01602.20 ORX67608.1 - 2.8e-08 32.8 0.4 0.0015 17.1 0.0 3.0 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 ORX67608.1 - 8.7e-07 29.1 1.2 0.11 12.5 0.1 4.5 4 2 1 6 6 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX67608.1 - 4.4e-06 26.4 1.8 0.0022 17.6 0.1 4.1 4 1 1 5 5 5 2 CLASP N terminal DUF3385 PF11865.8 ORX67608.1 - 5.6e-06 26.3 1.5 0.15 11.9 0.8 7.2 9 1 0 9 9 9 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 ORX67608.1 - 0.00057 19.1 0.4 0.047 12.8 0.1 3.3 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal DNA_alkylation PF08713.11 ORX67608.1 - 0.027 14.2 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 DNA alkylation repair enzyme Topoisom_I_N PF02919.15 ORX67608.1 - 0.04 13.4 0.2 0.075 12.5 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Cnd3 PF12719.7 ORX67608.1 - 0.04 13.1 7.1 3.4 6.8 0.0 4.4 4 2 2 6 6 6 0 Nuclear condensing complex subunits, C-term domain FANCI_S3 PF14677.6 ORX67608.1 - 0.055 13.2 1.4 0.96 9.1 0.0 3.4 4 0 0 4 4 4 0 FANCI solenoid 3 Not1 PF04054.15 ORX67608.1 - 0.056 12.4 0.0 0.17 10.8 0.0 1.8 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 Cohesin_HEAT PF12765.7 ORX67608.1 - 0.056 13.8 0.0 3 8.2 0.1 2.9 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion RTP1_C1 PF10363.9 ORX67608.1 - 0.14 12.4 2.4 3 8.0 0.2 3.9 2 2 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_N PF03224.14 ORX67608.1 - 0.25 10.6 2.4 4.4 6.5 0.1 3.0 2 1 0 2 2 2 0 V-ATPase subunit H DUF3361 PF11841.8 ORX67608.1 - 0.74 9.7 2.5 29 4.6 0.4 3.9 3 2 1 4 4 4 0 Domain of unknown function (DUF3361) Telomere_reg-2 PF10193.9 ORX67608.1 - 2.4 8.7 5.7 41 4.7 0.1 4.1 4 0 0 4 4 2 0 Telomere length regulation protein DNA_topoisoIV PF00521.20 ORX67609.1 - 2.4e-121 405.6 0.2 7e-121 404.1 0.0 2.0 3 0 0 3 3 3 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ORX67609.1 - 7.4e-44 149.1 6.2 7.4e-44 149.1 6.2 2.0 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ORX67609.1 - 2.6e-24 85.6 0.6 7.8e-24 84.1 0.6 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ORX67609.1 - 1e-13 51.8 2.1 2e-13 50.9 0.1 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ORX67609.1 - 1.4e-05 25.3 0.0 6.4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Toprim domain HATPase_c_3 PF13589.6 ORX67609.1 - 0.0015 18.4 9.0 0.0018 18.1 0.4 3.5 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EAL PF00563.20 ORX67609.1 - 0.11 11.9 0.1 0.65 9.5 0.0 2.0 2 0 0 2 2 2 0 EAL domain Hus1 PF04005.12 ORX67611.1 - 5.6e-06 25.7 0.1 1e-05 24.8 0.1 1.4 1 1 0 1 1 1 1 Hus1-like protein Pterin_4a PF01329.19 ORX67611.1 - 0.037 14.2 0.1 0.062 13.5 0.1 1.4 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase zf-C2H2 PF00096.26 ORX67612.1 - 0.13 12.7 0.2 0.25 11.9 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF2417 PF10329.9 ORX67613.1 - 0.87 9.0 5.6 1.8 7.9 5.6 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) NPL4 PF05021.15 ORX67614.1 - 3.9e-88 295.7 0.0 2.3e-87 293.2 0.0 1.9 1 1 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 ORX67614.1 - 3.6e-58 195.8 2.4 1.9e-57 193.5 2.4 2.0 1 1 0 1 1 1 1 NPL4 family, putative zinc binding region zf-RanBP PF00641.18 ORX67614.1 - 9.5 5.6 11.0 0.095 12.0 2.9 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others TRAPP PF04051.16 ORX67615.1 - 1.2e-24 86.7 0.0 2e-24 86.0 0.0 1.4 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component MtrG PF04210.13 ORX67615.1 - 0.46 10.4 3.3 4.8 7.1 0.0 3.4 3 1 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G UPF0176_N PF17773.1 ORX67616.1 - 2.7e-16 59.7 0.0 4.9e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 ORX67616.1 - 1.8e-15 57.0 11.5 3.9e-15 56.0 11.5 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 ORX67616.1 - 9.8e-08 32.5 0.0 1.9e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain BRCT PF00533.26 ORX67616.1 - 0.056 13.8 0.5 0.1 13.0 0.5 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Lectin_N PF03954.14 ORX67618.1 - 0.076 12.8 1.7 0.17 11.6 1.7 1.6 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain BHD_3 PF10405.9 ORX67619.1 - 1.7e-22 79.6 0.0 3.3e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 ORX67619.1 - 1.2e-17 64.6 0.3 1.2e-17 64.6 0.3 3.0 3 1 0 3 3 3 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 ORX67619.1 - 2.8e-14 52.7 0.2 1.6e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 ORX67619.1 - 9.7e-14 51.3 2.9 1e-11 44.7 2.9 2.6 1 1 0 1 1 1 1 Rad4 transglutaminase-like domain PI-PLC-X PF00388.19 ORX67620.1 - 3.8e-30 104.4 4.8 3.5e-24 85.0 0.1 3.1 2 1 1 3 3 3 2 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 ORX67620.1 - 4e-22 78.7 0.6 2.6e-21 76.1 0.6 2.2 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain Flavi_NS5 PF00972.20 ORX67620.1 - 0.064 11.4 0.4 0.11 10.6 0.4 1.2 1 0 0 1 1 1 0 Flavivirus RNA-directed RNA polymerase DUF3246 PF11596.8 ORX67620.1 - 0.069 12.6 0.3 0.14 11.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) ZZ PF00569.17 ORX67620.1 - 0.097 12.5 0.5 0.21 11.4 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF2895 PF11444.8 ORX67620.1 - 0.13 11.6 0.0 0.88 8.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2895) PH_12 PF16457.5 ORX67620.1 - 0.15 12.6 0.0 0.45 11.0 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Glyco_hydro_38N PF01074.22 ORX67622.1 - 2e-54 184.9 3.6 3e-54 184.3 3.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 ORX67622.1 - 2.3e-14 53.3 0.4 4.5e-14 52.4 0.4 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 ORX67622.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain Lipase_3 PF01764.25 ORX67623.1 - 2.7e-36 124.5 0.0 3.4e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ORX67623.1 - 0.0084 15.4 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX67623.1 - 0.012 16.3 0.2 0.013 16.1 0.2 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 ORX67623.1 - 0.025 14.5 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Cutinase DUF900 PF05990.12 ORX67623.1 - 0.17 11.3 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 ORX67624.1 - 5.3e-40 136.6 0.0 8.2e-40 135.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX67624.1 - 9.2e-05 22.1 0.3 0.00036 20.1 0.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 ORX67624.1 - 0.0001 21.7 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX67624.1 - 0.00033 21.3 0.1 0.00071 20.2 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX67624.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Cutinase PF01083.22 ORX67624.1 - 0.041 13.8 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Cutinase DUF4038 PF13204.6 ORX67624.1 - 0.097 12.3 1.1 0.42 10.2 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4038) Lipase_3 PF01764.25 ORX67625.1 - 5.7e-39 133.2 0.0 7.4e-39 132.9 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ORX67625.1 - 0.00016 21.0 0.1 0.00023 20.5 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 ORX67625.1 - 0.00062 19.4 0.0 0.001 18.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX67625.1 - 0.0012 19.5 0.1 0.0013 19.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.22 ORX67625.1 - 0.023 14.6 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.20 ORX67625.1 - 0.039 13.6 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 ORX67625.1 - 0.19 11.2 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PPR_2 PF13041.6 ORX67626.1 - 1.5e-19 69.9 1.1 2.7e-08 33.9 0.1 5.2 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 ORX67626.1 - 5e-10 38.9 12.9 0.0004 20.4 0.6 4.9 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ORX67626.1 - 1.4e-09 37.9 1.1 0.00024 21.1 0.0 5.0 2 2 3 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX67626.1 - 2.7e-05 23.8 0.4 0.6 9.9 0.2 4.0 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 ORX67626.1 - 0.0047 16.3 0.7 0.3 10.4 0.3 2.8 3 1 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP Peptidase_M41 PF01434.18 ORX67626.1 - 0.033 14.0 0.1 0.077 12.8 0.1 1.6 1 0 0 1 1 1 0 Peptidase family M41 FRB_dom PF08771.11 ORX67626.1 - 0.99 9.9 3.4 1.4 9.3 0.4 2.8 3 0 0 3 3 3 0 FKBP12-rapamycin binding domain PIG-Y PF15159.6 ORX67627.1 - 2.9e-21 76.2 5.7 3.2e-21 76.0 5.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIG-P PF08510.12 ORX67627.1 - 0.023 14.6 4.0 0.027 14.4 4.0 1.1 1 0 0 1 1 1 0 PIG-P Dr_adhesin PF12393.8 ORX67627.1 - 0.12 12.7 0.4 0.12 12.7 0.4 1.7 2 0 0 2 2 2 0 Dr family adhesin TruD PF01142.18 ORX67628.1 - 3e-69 233.9 0.0 5.5e-68 229.7 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Rnk_N PF14760.6 ORX67628.1 - 0.91 10.1 3.2 0.77 10.3 0.8 2.1 2 0 0 2 2 2 0 Rnk N-terminus p450 PF00067.22 ORX67629.1 - 0.00019 20.3 0.0 0.0002 20.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cyto_heme_lyase PF01265.17 ORX67630.1 - 3e-64 217.4 7.4 2e-63 214.7 7.4 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase PCI PF01399.27 ORX67631.1 - 3.2e-13 50.1 0.3 1.2e-12 48.2 0.0 2.1 2 1 0 2 2 2 1 PCI domain Med16 PF11635.8 ORX67631.1 - 0.021 12.8 0.0 0.035 12.0 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 16 TPR_12 PF13424.6 ORX67632.1 - 0.024 14.9 0.5 1.2 9.5 0.0 3.4 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67632.1 - 0.058 14.0 1.5 0.06 14.0 0.3 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat G3P_antiterm PF04309.12 ORX67633.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator F-box-like PF12937.7 ORX67634.1 - 0.00023 21.0 0.1 0.00064 19.6 0.1 1.9 1 0 0 1 1 1 1 F-box-like Complex1_51K PF01512.17 ORX67635.1 - 3.8e-50 169.7 0.0 5.5e-50 169.2 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ORX67635.1 - 3e-28 97.7 0.2 5.7e-28 96.8 0.2 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ORX67635.1 - 1e-07 31.7 0.0 2.4e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 SLBB domain GHMP_kinases_C PF08544.13 ORX67635.1 - 0.067 13.6 0.1 9.5 6.7 0.0 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal DUF3568 PF12092.8 ORX67635.1 - 0.099 12.7 0.3 0.19 11.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Fer4 PF00037.27 ORX67636.1 - 1.2e-14 53.3 17.3 4.9e-09 35.6 4.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ORX67636.1 - 2.1e-13 50.6 10.2 3.5e-13 49.9 10.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ORX67636.1 - 1.6e-10 41.7 9.4 1.5e-05 25.8 0.5 2.4 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ORX67636.1 - 5.1e-10 39.3 33.3 2.3e-06 27.7 13.0 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 ORX67636.1 - 9.8e-10 38.4 22.0 6.9e-07 29.3 12.8 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 ORX67636.1 - 2.8e-09 37.0 10.3 5e-09 36.2 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ORX67636.1 - 7.1e-08 32.8 19.2 5.3e-05 23.6 11.3 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ORX67636.1 - 1.8e-07 30.9 17.7 0.00034 20.6 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 ORX67636.1 - 8.3e-07 28.7 12.0 0.0019 18.2 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 ORX67636.1 - 5.3e-06 26.5 11.0 0.00043 20.6 2.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 ORX67636.1 - 6.7e-05 23.3 11.4 0.0083 16.6 12.3 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 ORX67636.1 - 0.0041 17.6 14.9 0.22 12.1 2.9 2.6 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 ORX67636.1 - 0.0069 17.3 16.5 0.013 16.4 4.2 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_18 PF13746.6 ORX67636.1 - 0.026 14.7 9.2 1.5 9.1 1.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 ORX67636.1 - 0.049 13.9 5.3 0.31 11.3 0.3 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain ETF_QO PF05187.13 ORX67636.1 - 0.14 12.3 6.8 2.3 8.4 1.5 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 ORX67636.1 - 0.27 12.1 11.4 1.1 10.2 1.3 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain EPF PF17181.4 ORX67636.1 - 0.82 9.7 5.7 0.42 10.6 0.8 2.2 2 0 0 2 2 2 0 Epidermal patterning factor proteins TFIIF_alpha PF05793.12 ORX67637.1 - 9.6e-23 80.6 69.1 1.7e-22 79.7 55.8 3.3 2 2 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SNARE PF05739.19 ORX67637.1 - 0.031 14.3 0.1 0.089 12.8 0.1 1.8 1 0 0 1 1 1 0 SNARE domain Mito_carr PF00153.27 ORX67638.1 - 5.3e-70 231.4 5.1 7.7e-25 86.7 0.3 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX67638.1 - 0.0051 16.0 3.3 0.2 10.8 0.0 3.0 2 1 1 3 3 3 1 Gammaproteobacterial serine protease TPPK_C PF12555.8 ORX67638.1 - 0.12 12.4 0.6 28 4.9 0.0 3.0 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal DUF2523 PF10734.9 ORX67638.1 - 0.27 11.9 2.0 5 7.8 0.1 3.6 4 1 1 5 5 5 0 Protein of unknown function (DUF2523) PT-VENN PF04829.13 ORX67638.1 - 6.2 7.0 8.0 41 4.3 1.1 3.4 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif tRNA-synt_2c PF01411.19 ORX67639.1 - 1.6e-18 66.6 0.0 2.2e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ORX67639.1 - 1.5e-07 31.3 0.1 3.6e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain E1_FCCH PF16190.5 ORX67639.1 - 0.066 13.4 0.3 0.8 10.0 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 FCCH domain Glyco_transf_15 PF01793.16 ORX67640.1 - 4.2e-86 289.1 2.2 5.2e-86 288.9 2.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Sulfate_transp PF00916.20 ORX67641.1 - 9.8e-106 353.7 14.0 1.2e-105 353.4 14.0 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX67641.1 - 7.5e-08 32.0 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX67641.1 - 0.0017 18.7 11.5 0.0021 18.4 4.3 2.8 2 0 0 2 2 2 1 Molybdate transporter of MFS superfamily UBX PF00789.20 ORX67642.1 - 1.9e-09 37.6 0.0 4.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 UBX domain TFIIA PF03153.13 ORX67642.1 - 0.044 13.8 7.4 0.0065 16.5 4.1 1.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Macro PF01661.21 ORX67644.1 - 5.9e-39 132.8 0.1 8.2e-39 132.3 0.1 1.2 1 0 0 1 1 1 1 Macro domain RasGAP PF00616.19 ORX67645.1 - 6.2e-43 146.9 0.0 9.4e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX67645.1 - 2e-13 50.6 0.0 7.8e-13 48.7 0.0 2.0 2 1 0 2 2 2 1 RasGAP C-terminus Mog1 PF04603.12 ORX67646.1 - 4.8e-39 133.9 0.1 5.4e-39 133.7 0.1 1.0 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SPACA9 PF15120.6 ORX67646.1 - 0.14 11.9 0.1 0.31 10.8 0.0 1.6 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 UPF0220 PF05255.11 ORX67647.1 - 4.2e-45 153.3 0.8 5.2e-45 153.0 0.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF3917 PF13055.6 ORX67647.1 - 4.3 7.8 7.3 37 4.8 7.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3917) SH3_9 PF14604.6 ORX67648.1 - 1.4e-23 82.5 0.2 1.5e-11 44.0 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ORX67648.1 - 3e-20 71.6 0.1 1.4e-09 37.5 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX67648.1 - 1.1e-19 69.7 0.0 9.6e-11 41.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 ORX67648.1 - 2.9e-09 36.7 5.8 5e-09 35.9 5.8 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.11 ORX67648.1 - 0.0013 18.6 1.5 0.0032 17.3 1.5 1.7 1 0 0 1 1 1 1 Putative transposase DNA-binding domain C1_2 PF03107.16 ORX67648.1 - 0.0065 16.8 0.9 0.011 16.1 0.9 1.4 1 0 0 1 1 1 1 C1 domain DZR PF12773.7 ORX67648.1 - 1.8 8.7 8.3 3.1 7.9 8.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon ACT_7 PF13840.6 ORX67649.1 - 4.6e-10 39.2 0.0 6.9e-09 35.4 0.0 2.1 1 1 0 1 1 1 1 ACT domain DUF676 PF05057.14 ORX67650.1 - 0.0055 16.2 0.1 0.011 15.2 0.1 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) DUF3089 PF11288.8 ORX67650.1 - 0.055 13.0 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Hydrolase_4 PF12146.8 ORX67650.1 - 0.089 12.0 0.0 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF4404 PF14357.6 ORX67650.1 - 0.12 13.1 0.0 0.21 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) PGAP1 PF07819.13 ORX67650.1 - 0.15 11.8 0.1 0.33 10.7 0.1 1.6 1 0 0 1 1 1 0 PGAP1-like protein FA_hydroxylase PF04116.13 ORX67651.1 - 6.4e-24 84.8 21.8 6.4e-24 84.8 21.8 1.5 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily SNF2_N PF00176.23 ORX67653.1 - 3.2e-44 151.1 0.1 3.8e-42 144.3 0.1 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX67653.1 - 2.3e-05 24.7 0.0 6.6e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ORX67653.1 - 2.3e-05 23.7 1.4 3.8e-05 23.0 0.0 2.1 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ORX67653.1 - 2.4e-05 24.4 0.0 5.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 ORX67653.1 - 8.2e-05 22.4 5.9 0.0033 17.3 0.3 3.5 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 ORX67653.1 - 0.041 14.0 0.8 0.18 12.0 0.2 2.4 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 AAA_25 PF13481.6 ORX67653.1 - 0.12 12.0 0.0 0.45 10.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain C1_1 PF00130.22 ORX67653.1 - 0.25 11.2 2.1 0.54 10.2 2.1 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_17 PF17120.5 ORX67653.1 - 0.34 10.6 1.1 0.63 9.7 1.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 ORX67653.1 - 0.42 10.6 1.6 0.93 9.5 1.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 ORX67653.1 - 1.8 8.5 3.8 0.7 9.8 0.5 2.0 2 0 0 2 2 2 0 PHD-finger MgtE PF01769.16 ORX67654.1 - 6.3e-33 113.8 19.8 9.7e-22 77.7 4.6 2.6 3 0 0 3 3 3 2 Divalent cation transporter PRA1 PF03208.19 ORX67654.1 - 0.87 9.2 10.7 0.35 10.5 3.2 2.7 2 1 0 2 2 2 0 PRA1 family protein Phage_holin_3_3 PF16083.5 ORX67654.1 - 4.6 7.4 10.3 0.4 10.8 0.6 3.8 4 1 1 5 5 5 0 LydA holin phage, holin superfamily III Abhydrolase_1 PF00561.20 ORX67655.1 - 5.9e-51 173.6 0.0 1.3e-50 172.5 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX67655.1 - 3.4e-05 23.2 0.4 0.14 11.4 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 ORX67655.1 - 0.0013 18.4 0.1 0.0022 17.7 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 ORX67655.1 - 0.0084 16.7 0.1 0.012 16.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Metallophos PF00149.28 ORX67656.1 - 4.9e-35 121.9 0.3 6.1e-35 121.6 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX67656.1 - 0.076 13.2 0.0 0.099 12.8 0.0 1.4 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Acetyltransf_1 PF00583.25 ORX67657.1 - 7.1e-18 65.0 0.0 9.1e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX67657.1 - 1.7e-09 38.0 0.0 2.2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX67657.1 - 2.3e-08 34.0 0.0 3.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX67657.1 - 2e-07 30.8 0.0 3.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX67657.1 - 0.00012 22.8 0.0 0.00015 22.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX67657.1 - 0.00037 20.6 0.0 0.00047 20.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ORX67657.1 - 0.015 15.0 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX67657.1 - 0.061 13.5 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 ORX67657.1 - 0.09 12.9 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SAT PF16073.5 ORX67658.1 - 1.1e-18 67.8 0.0 1.4e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Apolipoprotein PF01442.18 ORX67659.1 - 0.42 10.5 24.6 0.21 11.4 2.9 3.6 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain Phe_tRNA-synt_N PF02912.18 ORX67659.1 - 8.2 6.4 7.8 11 6.1 0.0 3.8 4 0 0 4 4 4 0 Aminoacyl tRNA synthetase class II, N-terminal domain Trypsin PF00089.26 ORX67660.1 - 1.4e-38 132.9 2.6 1.4e-38 132.9 2.6 1.7 2 0 0 2 2 2 1 Trypsin DUF1986 PF09342.11 ORX67660.1 - 0.0018 18.6 0.0 0.0036 17.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) BUD22 PF09073.10 ORX67660.1 - 4.7 6.4 31.3 6.8 5.9 31.3 1.1 1 0 0 1 1 1 0 BUD22 Peptidase_M28 PF04389.17 ORX67661.1 - 1.9e-30 106.0 0.0 4.2e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX67661.1 - 6.6e-09 35.8 0.0 9.4e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 BAALC_N PF06989.12 ORX67661.1 - 0.032 14.6 2.2 0.13 12.6 0.1 2.5 2 0 0 2 2 2 0 BAALC N-terminus Complex1_51K PF01512.17 ORX67662.1 - 3e-43 147.3 0.0 4.8e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ORX67662.1 - 2.9e-28 97.7 0.2 5.3e-28 96.9 0.2 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ORX67662.1 - 1.1e-07 31.6 0.0 2.2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 SLBB domain MPC PF03650.13 ORX67664.1 - 5.7e-45 152.0 0.3 6.2e-45 151.9 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Sulfate_transp PF00916.20 ORX67665.1 - 3.2e-96 322.4 14.3 1.6e-71 241.1 3.6 2.1 1 1 1 2 2 2 2 Sulfate permease family MFS_MOT1 PF16983.5 ORX67665.1 - 0.0023 18.3 1.9 0.0023 18.3 1.9 2.9 3 1 1 4 4 4 1 Molybdate transporter of MFS superfamily AP3D1 PF06375.11 ORX67667.1 - 0.016 15.4 10.1 0.087 13.1 10.1 2.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Sec34 PF04136.15 ORX67667.1 - 0.07 13.0 0.7 0.17 11.7 0.7 1.7 1 0 0 1 1 1 0 Sec34-like family DUF1168 PF06658.12 ORX67667.1 - 0.28 11.0 24.3 0.99 9.2 18.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) FAM60A PF15396.6 ORX67667.1 - 0.82 9.6 8.4 0.33 10.9 4.3 2.4 2 0 0 2 2 2 0 Protein Family FAM60A D5_N PF08706.11 ORX67667.1 - 1.3 9.3 5.6 0.57 10.4 0.2 2.8 3 0 0 3 3 3 0 D5 N terminal like DUF4746 PF15928.5 ORX67667.1 - 5.2 6.4 10.9 0.12 11.7 4.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CNDH2_C PF16858.5 ORX67667.1 - 5.9 6.7 14.3 0.13 12.1 5.5 2.6 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term ACOX PF01756.19 ORX67669.1 - 2.3e-38 131.5 0.0 3.8e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX67669.1 - 6e-22 78.5 0.1 1.5e-21 77.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX67669.1 - 3.5e-12 46.4 0.0 8.1e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ORX67669.1 - 0.00026 21.2 0.0 0.0052 17.0 0.0 3.0 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain 4HB PF17947.1 ORX67669.1 - 0.18 11.9 0.0 0.45 10.6 0.0 1.6 1 0 0 1 1 1 0 Four helical bundle domain Mob1_phocein PF03637.17 ORX67670.1 - 7.3e-28 97.7 0.5 9e-28 97.4 0.5 1.0 1 0 0 1 1 1 1 Mob1/phocein family Acid_PPase PF12689.7 ORX67671.1 - 2.6e-31 108.8 0.0 2.9e-31 108.6 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase ABC_tran PF00005.27 ORX67672.1 - 5.6e-50 169.4 0.0 6.3e-30 104.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX67672.1 - 1.2e-20 74.3 9.4 5.2e-13 49.3 4.5 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX67672.1 - 9.4e-07 28.5 0.1 0.2 11.1 0.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX67672.1 - 0.0078 16.3 0.0 5.1 7.2 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX67672.1 - 0.012 15.5 0.3 2.4 8.0 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 ORX67672.1 - 0.012 15.3 0.2 2.1 8.2 0.1 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX67672.1 - 0.013 15.9 0.7 0.56 10.6 0.1 3.2 3 0 0 3 3 3 0 AAA ATPase domain DEAD PF00270.29 ORX67672.1 - 0.021 14.6 0.1 0.71 9.6 0.0 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 ORX67672.1 - 0.05 13.3 0.1 1.5 8.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 ORX67672.1 - 0.094 12.2 0.1 1 8.9 0.0 2.5 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_22 PF13401.6 ORX67672.1 - 0.21 11.9 0.4 2.2 8.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 ORX67672.1 - 0.51 10.4 1.5 15 5.6 0.1 2.4 2 0 0 2 2 2 0 Dynamin family SAT PF16073.5 ORX67673.1 - 5.2e-05 23.1 0.0 0.00011 22.1 0.0 1.5 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ORX67673.1 - 9.6e-05 22.4 0.6 0.00066 19.7 0.6 2.2 1 1 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Acetyltransf_1 PF00583.25 ORX67674.1 - 1.8e-16 60.4 0.0 3.2e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MaoC_dehydratas PF01575.19 ORX67674.1 - 2.1e-16 59.6 0.0 5e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ORX67674.1 - 6.8e-09 36.0 0.0 2.6e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Acetyltransf_7 PF13508.7 ORX67674.1 - 1.8e-08 34.6 0.0 4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX67674.1 - 9.1e-08 32.1 0.0 1.7e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX67674.1 - 2.1e-06 27.6 0.1 4.2e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX67674.1 - 0.00067 20.3 0.0 0.0016 19.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX67674.1 - 0.0073 16.4 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ORX67674.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3910 PF13049.6 ORX67674.1 - 0.15 12.3 0.2 0.66 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3910) TPR_14 PF13428.6 ORX67675.1 - 2.1e-14 53.0 28.1 0.0074 17.0 0.1 11.6 9 3 4 13 13 13 3 Tetratricopeptide repeat Suf PF05843.14 ORX67675.1 - 9.6e-13 48.8 0.1 0.0019 18.3 0.0 4.9 3 2 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 ORX67675.1 - 8.1e-09 35.9 9.2 0.2 12.2 0.0 5.9 6 1 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX67675.1 - 1.9e-07 30.7 18.1 0.0025 17.8 0.2 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX67675.1 - 9.4e-07 29.0 11.2 0.014 15.7 0.0 6.4 6 1 0 6 6 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ORX67675.1 - 0.00019 21.4 2.4 4 7.4 0.0 5.9 7 0 0 7 7 7 1 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 ORX67675.1 - 0.00032 20.7 4.1 0.0069 16.5 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX67675.1 - 0.00032 19.9 4.9 0.42 9.7 0.0 5.6 3 2 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_1 PF00515.28 ORX67675.1 - 0.015 15.1 9.6 0.065 13.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX67675.1 - 0.021 15.2 8.2 2.2 8.8 0.0 6.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67675.1 - 0.021 15.5 27.9 1.1 10.0 0.1 8.0 8 1 0 8 8 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX67675.1 - 0.026 14.6 0.1 0.026 14.6 0.1 5.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX67675.1 - 0.039 13.8 18.4 0.068 13.1 0.1 6.0 8 0 0 8 8 6 0 Tetratricopeptide repeat PPR PF01535.20 ORX67675.1 - 0.061 13.6 4.2 3 8.3 0.0 5.4 7 0 0 7 7 7 0 PPR repeat TPR_9 PF13371.6 ORX67675.1 - 0.078 13.1 0.2 0.078 13.1 0.2 5.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX67675.1 - 0.085 13.5 12.0 12 6.8 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 ORX67675.1 - 0.17 12.6 0.1 0.17 12.6 0.1 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX67675.1 - 0.2 11.4 4.8 8 6.2 0.1 4.7 5 0 0 5 5 5 0 TPR repeat Flavokinase PF01687.17 ORX67676.1 - 2.3e-35 121.2 0.0 2.7e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase HEAT PF02985.22 ORX67677.1 - 2.8e-05 24.0 1.3 0.14 12.5 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 ORX67677.1 - 0.001 19.5 4.0 0.77 10.3 0.0 4.3 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 ORX67677.1 - 0.072 13.1 0.9 21 5.1 0.1 3.6 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 ABC_tran PF00005.27 ORX67678.1 - 2.5e-31 109.0 0.0 3.6e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX67678.1 - 0.00077 19.0 0.0 0.82 9.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 ORX67678.1 - 0.0014 18.3 0.1 0.19 11.4 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein DEAD PF00270.29 ORX67678.1 - 0.009 15.8 0.1 0.038 13.8 0.1 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_16 PF13191.6 ORX67678.1 - 0.015 15.7 0.4 0.041 14.3 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX67678.1 - 0.027 14.8 0.2 0.14 12.4 0.2 2.1 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 ORX67678.1 - 0.043 13.9 0.1 0.074 13.1 0.1 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA PF00004.29 ORX67678.1 - 0.06 13.8 0.0 0.36 11.2 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ORX67678.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ORX67678.1 - 0.095 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ORX67678.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 ORX67678.1 - 0.26 11.8 0.0 0.43 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain GATase_5 PF13507.6 ORX67679.1 - 1.6e-93 312.5 0.1 3.5e-93 311.5 0.1 1.6 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 ORX67679.1 - 1.2e-42 145.7 0.9 9.5e-28 97.3 0.1 2.7 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 ORX67679.1 - 1.9e-24 85.9 0.0 4e-24 84.8 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 ORX67679.1 - 1.5e-21 76.7 0.0 3.2e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 ORX67679.1 - 0.00075 20.1 1.3 0.28 11.9 0.1 3.1 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain iPGM_N PF06415.13 ORX67680.1 - 4.2e-77 258.4 0.0 6.6e-77 257.8 0.0 1.3 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 ORX67680.1 - 5.5e-71 238.8 0.0 6.3e-71 238.6 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 ORX67680.1 - 4.3e-08 33.2 0.0 8.3e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX67680.1 - 1.8e-06 27.6 0.0 3.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Sulfatase PglZ PF08665.12 ORX67680.1 - 0.021 14.9 0.0 0.057 13.5 0.0 1.7 2 0 0 2 2 2 0 PglZ domain OST3_OST6 PF04756.13 ORX67680.1 - 0.083 12.2 0.5 0.15 11.4 0.3 1.5 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family CLPTM1 PF05602.12 ORX67681.1 - 1.9e-06 27.2 0.0 1.3e-05 24.4 0.0 1.9 1 1 1 2 2 2 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) F-box-like_2 PF13013.6 ORX67682.1 - 0.097 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 F-box-like domain MFS_1 PF07690.16 ORX67684.1 - 4.5e-12 45.6 20.5 2.2e-11 43.3 19.8 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily SAT PF16073.5 ORX67685.1 - 1.6e-06 28.0 0.0 7.7e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ORX67685.1 - 0.00014 21.9 0.2 0.0003 20.8 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta DUF1729 PF08354.10 ORX67686.1 - 3.9e-31 108.3 0.2 4.7e-31 108.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydratas PF01575.19 ORX67687.1 - 1.8e-28 98.6 0.1 4e-28 97.4 0.0 1.6 2 0 0 2 2 2 1 MaoC like domain Acyl_transf_1 PF00698.21 ORX67687.1 - 2.6e-16 60.1 0.8 5.9e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain FAS_I_H PF18314.1 ORX67688.1 - 2.5e-40 138.3 0.1 4.2e-40 137.6 0.1 1.3 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 ORX67688.1 - 1.6e-27 96.9 0.0 3.1e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 ORX67688.1 - 1.1e-18 67.7 0.1 1.8e-18 67.0 0.1 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX67688.1 - 0.00052 20.0 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 ORX67688.1 - 0.0037 16.8 0.2 0.48 9.9 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.23 ORX67688.1 - 0.038 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Tox-MPTase2 PF15638.6 ORX67688.1 - 0.056 13.2 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 Metallopeptidase toxin 2 ACP_syn_III PF08545.10 ORX67688.1 - 0.12 12.2 0.4 0.33 10.8 0.4 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III KR PF08659.10 ORX67688.1 - 0.14 12.0 0.0 0.83 9.5 0.0 2.2 2 0 0 2 2 2 0 KR domain p450 PF00067.22 ORX67689.1 - 2.2e-65 221.2 0.0 2.9e-65 220.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 ORX67691.1 - 1.9e-43 148.8 43.3 1.9e-43 148.8 43.3 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX67691.1 - 3.4e-20 72.0 17.5 6.3e-20 71.1 17.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX67691.1 - 3.1e-12 46.1 32.1 4.5e-12 45.6 16.3 2.6 2 0 0 2 2 2 2 Sugar (and other) transporter ABC_membrane PF00664.23 ORX67692.1 - 3.6e-23 82.6 5.9 5.3e-23 82.0 5.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX67692.1 - 1.6e-18 67.5 0.1 2.7e-17 63.6 0.1 2.3 1 1 0 1 1 1 1 ABC transporter T2SSE PF00437.20 ORX67692.1 - 0.015 14.4 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 ORX67692.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region SMC_N PF02463.19 ORX67692.1 - 2.4 7.5 4.1 1.6 8.1 0.1 2.3 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain GTP_EFTU PF00009.27 ORX67735.1 - 3.2e-45 154.0 0.1 8.4e-44 149.4 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 ORX67735.1 - 6.5e-17 61.6 4.7 8.9e-10 38.7 1.0 2.8 1 1 1 2 2 2 2 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ORX67735.1 - 1.1e-13 51.0 0.0 8.1e-13 48.2 0.0 2.3 1 1 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX67735.1 - 3.8e-06 27.2 1.9 9.2e-06 26.0 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ORX67735.1 - 2.2e-05 24.3 0.0 4.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_II PF14492.6 ORX67735.1 - 0.0002 21.4 0.0 0.00049 20.1 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ORX67735.1 - 0.00023 21.2 0.0 0.00047 20.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX67735.1 - 0.0052 16.2 0.0 0.012 15.0 0.0 1.8 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX67735.1 - 0.085 12.4 0.0 3.5 7.2 0.0 2.4 1 1 0 1 1 1 0 Ras family bZIP_1 PF00170.21 ORX67736.1 - 6e-16 58.3 11.5 1.6e-15 57.0 11.5 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX67736.1 - 2.7e-12 46.5 13.5 2.7e-12 46.5 13.5 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX67736.1 - 2e-06 28.2 6.0 2e-06 28.2 6.0 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor HALZ PF02183.18 ORX67736.1 - 0.0014 18.8 1.6 0.0024 18.1 1.6 1.3 1 0 0 1 1 1 1 Homeobox associated leucine zipper TolA_bind_tri PF16331.5 ORX67736.1 - 0.0024 17.9 1.2 0.0048 16.9 1.2 1.4 1 0 0 1 1 1 1 TolA binding protein trimerisation APC_N_CC PF16689.5 ORX67736.1 - 0.0039 17.2 2.8 0.007 16.4 2.8 1.3 1 0 0 1 1 1 1 Coiled-coil N-terminus of APC, dimerisation domain Fungal_TACC PF12709.7 ORX67736.1 - 0.0091 16.4 1.3 0.016 15.7 1.3 1.3 1 0 0 1 1 1 1 Fungal Transforming acidic coiled-coil (TACC) proteins NRBF2 PF08961.10 ORX67736.1 - 0.016 14.8 0.7 0.036 13.7 0.7 1.6 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Nnf1 PF03980.14 ORX67736.1 - 0.029 14.8 0.5 0.029 14.8 0.5 2.4 2 0 0 2 2 2 0 Nnf1 DivIC PF04977.15 ORX67736.1 - 0.083 12.7 3.9 0.17 11.7 3.9 1.4 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 ORX67736.1 - 0.11 12.9 1.0 0.25 11.8 1.0 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 ORX67736.1 - 0.13 12.6 2.0 0.25 11.7 2.0 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Spc24 PF08286.11 ORX67736.1 - 0.14 12.4 0.5 0.3 11.4 0.5 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF5595 PF18077.1 ORX67736.1 - 0.23 11.6 2.2 0.36 11.0 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) XhlA PF10779.9 ORX67736.1 - 0.6 10.4 2.5 1.2 9.4 2.5 1.4 1 0 0 1 1 1 0 Haemolysin XhlA TMF_DNA_bd PF12329.8 ORX67736.1 - 0.95 9.5 6.3 0.59 10.2 4.4 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2013 PF09431.10 ORX67737.1 - 1.6e-31 109.3 0.3 1e-29 103.4 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2013) Mito_carr PF00153.27 ORX67738.1 - 4.2e-54 180.5 8.7 1.7e-20 72.7 0.2 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein CS PF04969.16 ORX67738.1 - 3.1e-06 28.1 0.0 5.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 CS domain Serine_protease PF18405.1 ORX67738.1 - 0.00087 18.5 0.2 0.011 14.9 0.0 2.2 2 0 0 2 2 2 1 Gammaproteobacterial serine protease Ribosomal_L7Ae PF01248.26 ORX67739.1 - 9.7e-26 89.4 0.3 1.5e-25 88.7 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ORX67739.1 - 0.00019 21.6 0.0 0.00027 21.0 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 CLTH PF10607.9 ORX67740.1 - 1.6e-33 115.6 0.0 3.3e-33 114.7 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 ORX67740.1 - 0.02 14.9 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 0 RING-type zinc-finger HAMP PF00672.25 ORX67740.1 - 0.11 12.9 0.1 0.31 11.4 0.1 1.8 1 0 0 1 1 1 0 HAMP domain NADH-G_4Fe-4S_3 PF10588.9 ORX67740.1 - 0.14 11.7 0.7 0.36 10.4 0.7 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region ubiquitin PF00240.23 ORX67741.1 - 3.1e-14 52.5 0.0 7.5e-14 51.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX67741.1 - 6e-05 22.8 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX67741.1 - 0.015 15.8 0.0 0.056 14.0 0.0 2.0 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX67741.1 - 0.048 13.8 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HAUS6_N PF14661.6 ORX67742.1 - 0.0072 15.9 2.3 0.0088 15.6 2.3 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Anp1 PF03452.14 ORX67743.1 - 3.1e-75 253.0 0.2 3.9e-75 252.7 0.2 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 ORX67743.1 - 3.8e-08 33.3 0.7 1.5e-06 28.1 0.6 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 2 DUF3770 PF12603.8 ORX67743.1 - 0.087 12.3 0.0 16 4.9 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3770) tRNA-synt_2b PF00587.25 ORX67744.1 - 6.5e-38 130.5 0.0 9e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX67744.1 - 6.4e-07 29.4 0.0 3.2e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 Anticodon binding domain SAPS PF04499.15 ORX67745.1 - 0.25 10.1 9.0 0.099 11.4 0.1 3.3 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Cofilin_ADF PF00241.20 ORX67747.1 - 3.4e-14 52.7 0.0 1.7e-06 27.9 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF4203 PF13886.6 ORX67748.1 - 1.3e-34 119.6 29.4 1.3e-34 119.6 29.4 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) DUF1129 PF06570.11 ORX67748.1 - 1.6 8.1 7.5 0.14 11.6 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF4203 PF13886.6 ORX67749.1 - 7.9e-26 91.0 28.9 9.4e-26 90.7 28.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) TraQ PF09679.10 ORX67749.1 - 0.013 15.4 3.2 0.015 15.2 0.8 2.4 2 1 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) DUF4149 PF13664.6 ORX67749.1 - 0.029 14.7 5.8 1.6 9.1 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) CcmD PF04995.14 ORX67749.1 - 0.066 13.3 0.2 0.066 13.3 0.2 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) UPF0154 PF03672.13 ORX67749.1 - 1 9.4 0.1 1 9.4 0.1 3.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) VHS PF00790.19 ORX67750.1 - 1.1e-25 90.2 0.4 1e-23 83.8 0.1 3.3 2 1 0 2 2 2 1 VHS domain GAT PF03127.14 ORX67750.1 - 3e-08 33.8 3.6 4e-07 30.2 0.2 3.5 4 0 0 4 4 4 1 GAT domain GGA_N-GAT PF18308.1 ORX67750.1 - 1.5e-05 24.5 1.5 0.00028 20.4 0.3 2.8 2 0 0 2 2 2 1 GGA N-GAT domain REV1_C PF16727.5 ORX67750.1 - 0.021 15.2 0.5 0.35 11.3 0.2 2.4 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Telomere_reg-2 PF10193.9 ORX67750.1 - 0.16 12.5 0.3 0.16 12.5 0.3 1.9 3 0 0 3 3 3 0 Telomere length regulation protein DUF3837 PF12939.7 ORX67750.1 - 4 7.9 6.6 0.75 10.2 0.8 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3837) G6PD_C PF02781.16 ORX67751.1 - 2e-87 293.1 0.0 1.5e-84 283.6 0.0 2.1 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ORX67751.1 - 4.7e-43 147.9 0.0 3.1e-42 145.2 0.0 2.1 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain IucA_IucC PF04183.12 ORX67752.1 - 3.1e-25 89.1 0.6 4.8e-25 88.5 0.6 1.3 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 ORX67752.1 - 2.4e-12 47.6 0.1 8.8e-12 45.7 0.1 1.9 2 0 0 2 2 2 1 Ferric iron reductase FhuF-like transporter EamA PF00892.20 ORX67754.1 - 0.0027 17.9 1.1 0.0027 17.9 1.1 2.0 1 1 1 2 2 2 1 EamA-like transporter family TMEM234 PF10639.9 ORX67754.1 - 0.011 15.8 0.4 0.014 15.5 0.4 1.2 1 0 0 1 1 1 0 Putative transmembrane family 234 Gar1 PF04410.14 ORX67755.1 - 2.8e-39 134.4 0.0 3.4e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region FoP_duplication PF13865.6 ORX67755.1 - 0.06 13.9 12.5 0.06 13.9 12.5 3.8 3 1 1 4 4 4 0 C-terminal duplication domain of Friend of PRMT1 Ycf9 PF01737.17 ORX67756.1 - 0.087 12.7 2.5 0.21 11.5 2.5 1.6 1 0 0 1 1 1 0 YCF9 DUF983 PF06170.12 ORX67756.1 - 4.8 7.7 10.1 0.14 12.6 1.8 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF983) DUF229 PF02995.17 ORX67757.1 - 1.1e-33 116.7 0.7 3e-25 88.8 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF229) Sulfatase PF00884.23 ORX67757.1 - 4.1e-06 26.4 0.2 0.00038 19.9 0.0 2.9 3 1 1 4 4 4 1 Sulfatase DUF1501 PF07394.12 ORX67757.1 - 0.043 12.9 0.1 0.076 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) TMEM206 PF15122.6 ORX67757.1 - 0.087 12.0 0.0 0.28 10.3 0.0 1.7 2 0 0 2 2 2 0 TMEM206 protein family Phosphodiest PF01663.22 ORX67757.1 - 0.1 12.2 0.1 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF2070 PF09843.9 ORX67757.1 - 8.1 4.6 8.5 12 4.1 8.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF229 PF02995.17 ORX67758.1 - 9.3e-36 123.5 0.8 4.3e-35 121.3 0.1 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 ORX67758.1 - 4.4e-06 26.3 0.2 0.00013 21.5 0.1 2.8 1 1 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 ORX67758.1 - 0.039 13.0 0.1 0.069 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF2070 PF09843.9 ORX67758.1 - 7.3 4.7 8.4 11 4.2 8.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) NCA2 PF08637.10 ORX67759.1 - 3.9e-59 200.2 0.1 6.5e-59 199.5 0.1 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 RNA_pol_L_2 PF13656.6 ORX67761.1 - 2.4e-29 100.9 0.0 3.7e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ORX67761.1 - 7.1e-10 38.2 0.0 1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain eIF3_N PF09440.10 ORX67762.1 - 6.2e-46 156.1 5.2 6.2e-46 156.1 5.2 2.5 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 ORX67762.1 - 1.9e-13 50.8 0.0 6.4e-13 49.1 0.0 2.0 1 0 0 1 1 1 1 PCI domain DUF771 PF05595.11 ORX67762.1 - 0.065 13.2 1.4 0.38 10.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF771) TPR_9 PF13371.6 ORX67762.1 - 0.14 12.3 0.0 0.53 10.5 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ACP_PD PF04336.12 ORX67762.1 - 0.5 10.8 6.9 0.26 11.7 0.5 3.3 3 1 0 3 3 3 0 Acyl carrier protein phosphodiesterase Ribosomal_L6e PF01159.19 ORX67763.1 - 8.9e-40 135.7 1.8 1.3e-39 135.2 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 ORX67763.1 - 2.7e-05 24.3 3.8 2.7e-05 24.3 3.8 1.9 2 0 0 2 2 2 1 Ribosomal protein L6, N-terminal domain OAD_gamma PF04277.13 ORX67763.1 - 4.2 8.0 14.6 1.1 9.9 4.3 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Img2 PF05046.14 ORX67764.1 - 9e-29 99.6 0.1 1.1e-28 99.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.22 ORX67764.1 - 0.015 15.8 0.0 0.026 15.0 0.0 1.5 1 1 0 1 1 1 0 Translation initiation factor SUI1 F-box-like PF12937.7 ORX67765.1 - 0.0062 16.4 0.0 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 F-box-like tRNA-synt_1b PF00579.25 ORX67767.1 - 2.7e-66 223.9 0.0 8.4e-66 222.3 0.0 1.7 1 1 1 2 2 2 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 ORX67767.1 - 0.0091 15.8 0.0 0.049 13.5 0.0 2.1 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 ORX67767.1 - 0.15 11.8 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 S4 domain Phosphodiest PF01663.22 ORX67768.1 - 4e-09 36.5 0.0 5.9e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX67768.1 - 0.0076 15.7 0.0 0.024 14.1 0.0 1.7 1 1 0 1 1 1 1 Sulfatase UQ_con PF00179.26 ORX67769.1 - 8.4e-12 44.9 0.2 1.9e-11 43.8 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX67769.1 - 0.11 12.8 0.1 0.21 11.9 0.1 1.4 1 1 0 1 1 1 0 RWD domain Rpr2 PF04032.16 ORX67770.1 - 1.8e-06 28.1 4.4 1.8e-06 28.1 4.4 2.6 2 1 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4674 PF15719.5 ORX67770.1 - 0.00034 20.7 15.6 0.0009 19.3 15.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4674) FYVE PF01363.21 ORX67770.1 - 0.068 13.3 3.1 4.7 7.4 0.1 2.4 1 1 1 2 2 2 0 FYVE zinc finger Trypan_PARP PF05887.11 ORX67770.1 - 0.07 13.1 5.4 0.023 14.7 2.7 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) zf-ribbon_3 PF13248.6 ORX67770.1 - 0.086 12.3 0.1 0.25 10.8 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain DUF2868 PF11067.8 ORX67770.1 - 2.9 7.3 6.3 5 6.5 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) CDK5_activator PF03261.15 ORX67770.1 - 3.5 7.1 9.4 7.2 6.1 9.4 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ndc1_Nup PF09531.10 ORX67770.1 - 5.7 5.5 9.7 7.1 5.2 9.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3136 PF11334.8 ORX67772.1 - 0.048 13.4 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) Methyltransf_23 PF13489.6 ORX67772.1 - 0.081 12.8 0.2 0.39 10.5 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain DUF3537 PF12056.8 ORX67772.1 - 0.31 9.8 0.7 0.41 9.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) mono-CXXC PF15626.6 ORX67772.1 - 1.2 9.6 5.2 28 5.2 2.0 2.8 2 0 0 2 2 2 0 single CXXC unit Astro_capsid_p PF12226.8 ORX67772.1 - 3.7 6.6 7.0 5.6 6.0 7.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein zf-CHC2 PF01807.20 ORX67773.1 - 0.057 13.2 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 CHC2 zinc finger Pkinase PF00069.25 ORX67774.1 - 1.6e-63 214.6 0.0 1.9e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX67774.1 - 1.4e-34 119.6 0.0 1.7e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX67774.1 - 2.5e-08 33.6 0.0 1.7e-07 30.9 0.0 2.1 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX67774.1 - 0.00022 20.7 0.1 0.00041 19.8 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX67774.1 - 0.00069 19.3 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ORX67774.1 - 0.001 19.1 0.2 0.059 13.3 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX67774.1 - 0.0059 15.4 0.0 0.0089 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ORX67774.1 - 0.01 15.4 0.1 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 MMM1 PF10296.9 ORX67776.1 - 3.9e-49 167.5 0.0 2.1e-37 128.9 0.0 2.0 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 IPK PF03770.16 ORX67777.1 - 1e-38 133.2 0.0 1.2e-38 132.9 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase SET PF00856.28 ORX67778.1 - 9e-13 49.0 0.2 2.2e-12 47.7 0.2 1.7 1 1 0 1 1 1 1 SET domain HTH_21 PF13276.6 ORX67778.1 - 0.00096 19.2 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 HTH-like domain Rhomboid PF01694.22 ORX67779.1 - 1e-31 110.0 11.6 1e-31 110.0 11.6 1.5 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ORX67779.1 - 0.00059 20.4 0.0 0.0013 19.2 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Imm7 PF15585.6 ORX67779.1 - 0.19 12.0 0.0 2.2 8.6 0.0 2.0 2 0 0 2 2 2 0 Immunity protein 7 TPR_19 PF14559.6 ORX67780.1 - 2.5e-11 43.9 20.6 9.9e-05 22.8 0.5 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX67780.1 - 4e-10 39.1 11.4 0.0023 18.0 0.0 7.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX67780.1 - 3.1e-09 36.9 18.1 0.029 15.2 1.2 6.5 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX67780.1 - 5.2e-08 32.7 5.9 0.069 13.6 0.1 5.4 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX67780.1 - 2.5e-07 30.2 3.2 0.15 11.9 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX67780.1 - 2.5e-07 30.3 18.3 0.16 12.2 0.0 7.6 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX67780.1 - 6.3e-07 29.5 6.0 0.00034 20.8 0.2 3.3 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX67780.1 - 2e-06 27.4 2.1 0.56 10.4 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67780.1 - 3.4e-06 27.6 7.8 0.0023 18.5 0.4 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX67780.1 - 7.6e-05 22.9 6.5 0.0081 16.4 0.0 4.9 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX67780.1 - 0.00028 20.4 8.6 0.0025 17.3 2.8 3.1 1 1 1 3 3 3 1 MalT-like TPR region TPR_6 PF13174.6 ORX67780.1 - 0.00058 20.3 11.5 0.094 13.4 0.0 5.6 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX67780.1 - 0.0013 18.8 13.0 0.0097 16.0 0.0 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat PknG_TPR PF16918.5 ORX67780.1 - 0.0061 15.3 0.6 0.043 12.5 0.1 2.1 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat ANAPC5 PF12862.7 ORX67780.1 - 0.0094 16.0 1.5 19 5.4 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 NARP1 PF12569.8 ORX67780.1 - 0.014 14.4 1.4 1.6 7.6 0.0 2.9 2 1 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 ORX67780.1 - 0.02 15.2 10.4 0.78 10.1 0.7 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX67780.1 - 0.033 13.9 6.3 18 5.1 0.0 5.8 6 1 1 7 7 7 0 TPR repeat Fis1_TPR_C PF14853.6 ORX67780.1 - 0.21 11.7 0.1 0.21 11.7 0.1 3.8 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ORX67780.1 - 0.25 11.8 0.3 0.25 11.8 0.3 2.5 3 1 1 4 4 4 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 ORX67780.1 - 1.9 8.5 5.9 44 4.1 0.5 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF2786 PF10979.8 ORX67780.1 - 2.4 8.2 10.2 6.8 6.7 0.1 3.8 4 0 0 4 4 3 0 Protein of unknown function (DUF2786) Macoilin PF09726.9 ORX67782.1 - 0.18 10.3 36.0 0.28 9.7 36.0 1.2 1 0 0 1 1 1 0 Macoilin family APG6_N PF17675.1 ORX67782.1 - 0.3 11.6 57.6 0.08 13.5 23.1 3.5 2 1 1 3 3 3 0 Apg6 coiled-coil region Tup_N PF08581.10 ORX67782.1 - 1.8 8.9 20.4 5.6 7.3 4.2 2.9 2 0 0 2 2 2 0 Tup N-terminal DUF805 PF05656.14 ORX67782.1 - 7.8 7.0 10.8 0.059 13.8 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF805) F-box-like PF12937.7 ORX67784.1 - 0.021 14.7 0.0 0.08 12.9 0.0 2.1 2 0 0 2 2 2 0 F-box-like LRR_4 PF12799.7 ORX67784.1 - 0.063 13.7 0.4 5.3 7.6 0.3 3.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Amino_oxidase PF01593.24 ORX67785.1 - 3.5e-29 102.4 0.4 4.5e-29 102.0 0.4 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX67785.1 - 2.6e-11 43.6 0.1 5.2e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX67785.1 - 1.7e-07 31.1 9.0 1.4e-06 28.1 9.0 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX67785.1 - 0.00045 19.5 0.1 0.0034 16.7 0.1 2.0 2 0 0 2 2 2 1 Thi4 family Trp_halogenase PF04820.14 ORX67785.1 - 0.0014 17.6 2.0 0.053 12.4 0.3 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 ORX67785.1 - 0.0069 15.7 0.1 0.026 13.7 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX67785.1 - 0.024 14.6 4.9 0.12 12.3 0.1 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 ORX67785.1 - 0.055 14.0 0.0 1.2 9.7 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DEAD PF00270.29 ORX67787.1 - 6.7e-37 126.9 0.0 9.5e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX67787.1 - 1.4e-21 76.9 0.0 9.8e-21 74.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX67787.1 - 1.7e-07 31.4 0.0 2.7e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 ORX67787.1 - 0.11 12.4 0.1 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 Flavivirus DEAD domain zf_C2HC_14 PF18574.1 ORX67787.1 - 0.36 10.6 0.9 9.2 6.2 0.1 2.5 2 0 0 2 2 2 0 C2HC Zing finger domain Lambda_tail_I PF06805.12 ORX67788.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly protein I Asp5 PF17000.5 ORX67788.1 - 0.91 9.7 4.2 0.26 11.5 0.9 1.8 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 F-box-like PF12937.7 ORX67790.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 0 F-box-like Lactamase_B_6 PF16661.5 ORX67793.1 - 5.7e-31 107.5 0.0 9.7e-31 106.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 ORX67793.1 - 1.3e-22 80.7 0.1 5.4e-19 69.0 0.0 2.5 1 1 1 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 ORX67793.1 - 8.4e-19 67.9 0.0 1.7e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 ORX67793.1 - 4.1e-10 39.5 0.0 8.3e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain TPR_14 PF13428.6 ORX67794.1 - 3.3e-06 27.5 41.0 0.0032 18.2 0.4 10.3 9 2 4 13 13 13 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX67794.1 - 1.4e-05 25.5 26.7 0.0041 17.6 0.1 7.7 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_20 PF14561.6 ORX67794.1 - 3.5e-05 24.0 4.2 0.25 11.7 0.0 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67794.1 - 8e-05 23.2 36.6 0.00014 22.4 0.4 7.9 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX67794.1 - 0.007 16.5 0.6 0.007 16.5 0.6 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX67794.1 - 0.013 15.1 8.6 17 5.2 0.0 5.5 4 1 1 5 5 5 0 TPR repeat TPR_17 PF13431.6 ORX67794.1 - 0.015 15.7 1.8 10 6.8 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX67794.1 - 0.021 14.6 1.3 10 6.2 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX67794.1 - 0.023 14.8 18.6 2 8.8 0.0 7.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX67794.1 - 7.1 7.0 21.4 7 7.0 0.2 6.9 5 2 1 7 7 7 0 Tetratricopeptide repeat CHD5 PF04420.14 ORX67795.1 - 6.9e-40 136.5 0.6 8.6e-40 136.2 0.6 1.1 1 0 0 1 1 1 1 CHD5-like protein T3SS_needle_E PF08988.10 ORX67795.1 - 0.032 14.4 0.1 0.082 13.1 0.1 1.6 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle DUF1515 PF07439.11 ORX67795.1 - 0.11 12.5 1.5 0.12 12.4 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF1970 PF09301.10 ORX67795.1 - 2 8.7 6.6 7.7 6.8 3.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1970) CBFD_NFYB_HMF PF00808.23 ORX67796.1 - 2.1e-12 47.1 1.5 3e-12 46.6 1.5 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX67796.1 - 0.009 16.4 0.5 0.009 16.4 0.5 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 API5 PF05918.11 ORX67796.1 - 4.3 6.0 7.1 7.6 5.2 7.1 1.3 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Ribosomal_S30 PF04758.14 ORX67797.1 - 1.4e-26 92.5 3.2 1.5e-26 92.3 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Abhydrolase_1 PF00561.20 ORX67799.1 - 6.9e-13 48.8 0.0 1.1e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX67799.1 - 2.8e-05 23.5 0.0 4.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Arf PF00025.21 ORX67800.1 - 3.5e-74 248.0 0.1 4.1e-74 247.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX67800.1 - 5.8e-14 52.3 0.0 7.8e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ORX67800.1 - 4.1e-13 49.2 0.9 4.7e-09 35.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX67800.1 - 7.7e-13 48.3 0.0 9.3e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX67800.1 - 2.5e-12 46.7 0.0 2.9e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ORX67800.1 - 4.1e-10 39.4 0.0 5e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX67800.1 - 9.8e-06 25.6 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ORX67800.1 - 0.0069 15.7 0.5 0.018 14.3 0.1 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase RF-1 PF00472.20 ORX67801.1 - 2.7e-18 66.0 2.1 4.3e-18 65.3 2.1 1.2 1 0 0 1 1 1 1 RF-1 domain ketoacyl-synt PF00109.26 ORX67802.1 - 7.6e-45 153.5 3.5 1.8e-39 135.8 0.6 2.3 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX67802.1 - 8.9e-19 67.7 0.5 1.2e-15 57.6 0.4 2.4 1 1 1 2 2 2 2 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ORX67802.1 - 0.00053 19.4 0.5 0.0016 17.8 0.0 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 ORX67802.1 - 0.033 14.0 0.6 2.4 8.1 0.0 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III KAsynt_C_assoc PF16197.5 ORX67802.1 - 0.06 13.8 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension Ribosomal_L30_N PF08079.12 ORX67803.1 - 7.8e-28 96.5 20.1 1.6e-27 95.6 20.1 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 ORX67803.1 - 3.2e-16 58.9 2.6 1.2e-15 57.1 2.6 2.1 1 1 0 1 1 1 1 Ribosomal protein L30p/L7e Mpp10 PF04006.12 ORX67803.1 - 2.4 6.5 8.7 2.7 6.3 8.7 1.0 1 0 0 1 1 1 0 Mpp10 protein Tubulin PF00091.25 ORX67804.1 - 7e-67 225.4 0.0 1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX67804.1 - 1.3e-48 164.3 0.0 2.1e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ORX67804.1 - 0.00011 21.9 0.0 0.00022 21.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain HECT PF00632.25 ORX67806.1 - 5.8e-85 285.5 0.0 8.1e-85 285.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GTP_EFTU PF00009.27 ORX67808.1 - 1.8e-08 34.2 0.1 4.9e-08 32.7 0.1 1.5 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ORX67808.1 - 0.1 12.4 0.9 0.33 10.7 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AlbA_2 PF04326.14 ORX67808.1 - 0.15 12.4 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative DNA-binding domain NPV_P10 PF05531.12 ORX67809.1 - 0.15 12.6 0.2 3.9 8.0 0.0 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Neur_chan_memb PF02932.16 ORX67809.1 - 1.4 8.9 3.6 0.46 10.5 0.5 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Glyco_transf_25 PF01755.17 ORX67810.1 - 0.002 18.0 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) TMEM132D_C PF15706.5 ORX67810.1 - 0.063 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ceramidase PF05875.12 ORX67812.1 - 3.3e-53 180.8 13.5 3.7e-53 180.6 13.5 1.0 1 0 0 1 1 1 1 Ceramidase DUF4199 PF13858.6 ORX67812.1 - 7.5 6.9 14.7 0.78 10.1 7.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) Pkinase PF00069.25 ORX67813.1 - 8.8e-61 205.6 0.0 1e-43 149.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX67813.1 - 1.3e-26 93.4 0.0 8.2e-18 64.6 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX67813.1 - 5.9e-06 25.8 0.1 0.00051 19.4 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 ORX67813.1 - 0.00048 20.1 0.4 0.0019 18.2 0.1 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX67813.1 - 0.017 14.5 0.9 0.53 9.6 0.0 2.3 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX67813.1 - 0.055 12.2 0.9 0.51 9.1 0.1 2.1 1 1 1 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 ORX67813.1 - 0.061 12.3 0.0 0.49 9.3 0.0 2.0 1 1 0 2 2 2 0 Haspin like kinase domain GST_N_3 PF13417.6 ORX67814.1 - 2.8e-17 62.9 0.0 5.1e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX67814.1 - 9.6e-16 57.9 0.0 1.7e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX67814.1 - 5.6e-13 49.0 0.0 9.5e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX67814.1 - 4.7e-07 29.9 0.0 8.6e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX67814.1 - 7.5e-07 29.1 0.0 1.2e-06 28.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX67814.1 - 5.2e-06 26.6 0.0 1e-05 25.6 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TSR PF18487.1 ORX67814.1 - 0.15 12.3 0.2 0.28 11.4 0.2 1.4 1 0 0 1 1 1 0 Thrombospondin type 1 repeat JAB PF01398.21 ORX67815.1 - 5.2e-13 49.0 0.1 1e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-binding PF00249.31 ORX67815.1 - 6.3e-10 39.1 0.0 1.8e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Prok-JAB PF14464.6 ORX67815.1 - 2.4e-09 37.0 0.0 7.3e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_6 PF13921.6 ORX67815.1 - 0.01 16.0 0.0 0.028 14.6 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF1682 PF07946.14 ORX67816.1 - 4.3e-39 134.6 18.7 6e-32 111.1 0.0 3.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1682) Radial_spoke_3 PF06098.11 ORX67816.1 - 0.5 9.6 9.6 0.77 9.0 9.6 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 PI3_PI4_kinase PF00454.27 ORX67818.1 - 1.2e-34 120.2 0.6 2.1e-33 116.2 0.6 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 ORX67818.1 - 0.093 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) EF1_GNE PF00736.19 ORX67819.1 - 3.8e-30 103.9 0.7 3.8e-30 103.9 0.7 1.6 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 ORX67819.1 - 9.6e-13 48.3 6.6 9.6e-13 48.3 6.6 2.5 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 ORX67819.1 - 0.00097 19.3 0.2 0.0031 17.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain WHEP-TRS PF00458.20 ORX67819.1 - 0.0021 18.1 3.1 0.0063 16.6 3.1 1.8 1 1 0 1 1 1 1 WHEP-TRS domain GST_C PF00043.25 ORX67819.1 - 0.23 11.7 2.6 0.34 11.2 0.1 2.4 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain S-AdoMet_synt_M PF02772.16 ORX67820.1 - 0.11 12.7 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, central domain MFS_1 PF07690.16 ORX67821.1 - 6.2e-10 38.5 12.5 7.5e-10 38.2 12.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily zf-CSL PF05207.13 ORX67821.1 - 0.013 15.2 0.1 0.025 14.3 0.1 1.5 1 0 0 1 1 1 0 CSL zinc finger WD40 PF00400.32 ORX67822.1 - 8.9e-17 61.2 0.9 0.0078 17.0 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX67822.1 - 3.1e-07 30.6 0.0 0.19 12.0 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Glyoxal_oxid_N PF07250.11 ORX67822.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus MMS1_N PF10433.9 ORX67822.1 - 0.096 11.3 0.0 2.4 6.7 0.0 2.1 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term GAF_2 PF13185.6 ORX67823.1 - 9.7e-10 38.9 0.0 1.2e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 ORX67823.1 - 5e-06 27.2 0.0 5.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ORX67823.1 - 0.0011 19.3 0.0 0.0016 18.8 0.0 1.2 1 0 0 1 1 1 1 GAF domain Acyltransferase PF01553.21 ORX67824.1 - 5.5e-25 87.5 0.0 7.8e-25 87.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Lip_A_acyltrans PF03279.13 ORX67824.1 - 0.068 12.3 0.0 0.14 11.3 0.0 1.6 1 1 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase Acyltransferase PF01553.21 ORX67825.1 - 4.8e-26 91.0 0.0 1.2e-25 89.6 0.0 1.6 2 0 0 2 2 2 1 Acyltransferase MoaF_C PF17409.2 ORX67825.1 - 0.11 12.2 0.0 11 5.7 0.0 2.2 2 0 0 2 2 2 0 MoaF C-terminal domain Pkinase PF00069.25 ORX67826.1 - 2.7e-38 131.9 0.0 1.9e-36 125.8 0.0 2.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX67826.1 - 4.7e-14 52.3 0.2 2.8e-13 49.7 0.1 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX67826.1 - 0.00077 18.9 0.1 0.0027 17.0 0.0 1.9 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX67826.1 - 0.0088 15.0 0.1 0.013 14.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX67826.1 - 0.011 15.7 0.4 2.1 8.2 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family STN1_2 PF09170.10 ORX67826.1 - 0.11 12.7 0.1 25 5.0 0.0 3.1 3 0 0 3 3 3 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Polyketide_cyc PF03364.20 ORX67827.1 - 2.2e-15 57.0 0.0 2.9e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport THOC7 PF05615.13 ORX67828.1 - 1.3e-14 54.6 5.4 1.3e-14 54.6 5.4 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 PilJ PF13675.6 ORX67828.1 - 0.003 17.6 3.4 0.003 17.6 3.4 2.1 1 1 1 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term APG6_N PF17675.1 ORX67828.1 - 0.054 14.0 20.0 0.1 13.1 13.0 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4874 PF16173.5 ORX67828.1 - 0.062 13.0 2.2 0.1 12.2 2.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4874) Peptidase_S46 PF10459.9 ORX67828.1 - 0.071 11.7 8.5 0.087 11.5 8.5 1.1 1 0 0 1 1 1 0 Peptidase S46 GAS PF13851.6 ORX67828.1 - 0.14 11.5 16.0 0.49 9.7 15.6 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 ORX67828.1 - 0.3 10.6 6.5 0.46 10.0 6.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 ORX67828.1 - 0.65 7.8 5.2 0.73 7.7 5.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF489 PF04356.12 ORX67828.1 - 0.66 10.0 7.1 2.9 7.8 7.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Spc7 PF08317.11 ORX67828.1 - 1.1 8.0 18.1 2.8 6.7 17.8 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.11 ORX67828.1 - 1.5 6.7 4.5 2.2 6.1 4.5 1.2 1 0 0 1 1 1 0 Prominin DUF1664 PF07889.12 ORX67828.1 - 1.9 8.6 9.3 0.78 9.8 4.5 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 ORX67828.1 - 2.3 7.0 5.7 2.8 6.7 5.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Seryl_tRNA_N PF02403.22 ORX67828.1 - 2.8 8.2 11.5 3.4 7.9 6.5 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Occludin_ELL PF07303.13 ORX67828.1 - 4.2 8.1 9.5 9.9 7.0 2.9 2.8 1 1 1 2 2 2 0 Occludin homology domain DUF4407 PF14362.6 ORX67828.1 - 4.3 6.6 17.7 2.1 7.6 15.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 ORX67828.1 - 5.6 5.9 13.8 14 4.6 2.7 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 ORX67828.1 - 5.9 7.4 19.0 0.096 13.1 5.1 3.0 3 0 0 3 3 3 0 Cell division protein ZapB DUF2205 PF10224.9 ORX67828.1 - 6.1 6.9 9.7 1.6 8.8 5.4 2.3 1 1 1 2 2 2 0 Short coiled-coil protein ZapD PF07072.11 ORX67828.1 - 8.9 6.0 11.9 1.8 8.3 7.0 2.0 1 1 1 2 2 2 0 Cell division protein MFS_1 PF07690.16 ORX67829.1 - 1.8e-25 89.7 53.0 1.2e-15 57.4 26.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA_U5-meth_tr PF05958.11 ORX67831.1 - 7e-10 38.4 0.1 2.5e-08 33.3 0.1 2.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 ORX67831.1 - 1.5e-07 31.2 0.0 2.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 ORX67831.1 - 3.7e-07 30.1 0.0 6.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX67831.1 - 2.8e-05 24.7 0.0 6.9e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltrans_SAM PF10672.9 ORX67831.1 - 0.00033 19.9 0.0 0.0005 19.3 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase PrmA PF06325.13 ORX67831.1 - 0.00051 19.5 0.1 0.00079 18.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ORX67831.1 - 0.00067 19.4 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX67831.1 - 0.0059 17.2 0.0 0.015 16.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX67831.1 - 0.0094 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase N6_N4_Mtase PF01555.18 ORX67831.1 - 0.15 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 DNA methylase Asparaginase_2 PF01112.18 ORX67832.1 - 9.9e-36 123.3 3.0 5.3e-22 78.2 0.0 2.2 2 0 0 2 2 2 2 Asparaginase WH2 PF02205.20 ORX67833.1 - 2e-11 43.3 1.3 7.9e-11 41.4 1.3 2.1 1 0 0 1 1 1 1 WH2 motif Totivirus_coat PF05518.11 ORX67833.1 - 2.6 6.0 10.9 3.2 5.7 10.9 1.1 1 0 0 1 1 1 0 Totivirus coat protein RhoGEF PF00621.20 ORX67836.1 - 2.8e-40 138.5 0.0 5.2e-40 137.6 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain LRR_8 PF13855.6 ORX67836.1 - 2.5e-18 65.6 27.2 8.7e-10 38.2 2.0 2.8 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ORX67836.1 - 1.2e-10 41.4 15.4 6.8e-06 26.3 3.7 3.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX67836.1 - 0.19 12.4 16.3 38 5.4 0.2 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat DUF1700 PF08006.11 ORX67837.1 - 1.1 8.8 4.2 3.3 7.2 3.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1700) AXH PF08517.12 ORX67838.1 - 0.19 12.3 0.8 0.38 11.3 0.2 1.7 1 1 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) Asparaginase_2 PF01112.18 ORX67839.1 - 8.6e-91 304.1 1.6 1.1e-90 303.8 1.6 1.0 1 0 0 1 1 1 1 Asparaginase MatE PF01554.18 ORX67840.1 - 5.2e-22 78.2 23.2 6.1e-10 39.0 2.2 4.9 3 2 2 5 5 5 3 MatE DASH_Dad1 PF08649.10 ORX67840.1 - 4.5e-14 52.4 3.0 7.6e-14 51.7 3.0 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad1 Uds1 PF15456.6 ORX67841.1 - 4.2e-10 39.9 5.8 4.2e-10 39.9 5.8 6.7 5 2 1 6 6 6 2 Up-regulated During Septation GAS PF13851.6 ORX67841.1 - 0.002 17.5 3.5 0.002 17.5 3.5 5.8 4 1 0 5 5 5 2 Growth-arrest specific micro-tubule binding NDUFA12 PF05071.16 ORX67842.1 - 2e-10 41.4 0.1 2.5e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 7tm_3 PF00003.22 ORX67843.1 - 4.5e-08 33.1 28.3 7.7e-08 32.4 28.3 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF423 PF04241.15 ORX67843.1 - 4 7.7 7.9 0.81 9.9 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF423) GDC-P PF02347.16 ORX67844.1 - 3.2e-195 649.0 0.8 7.3e-182 605.0 0.0 3.1 3 0 0 3 3 3 3 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 ORX67844.1 - 3.7e-05 23.1 0.1 0.00011 21.6 0.1 1.9 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX67844.1 - 4.7e-05 22.5 0.2 9.7e-05 21.5 0.2 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Lipase_3 PF01764.25 ORX67845.1 - 1.5e-39 135.1 0.0 2.4e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX67845.1 - 3e-05 23.7 2.2 0.00012 21.7 0.5 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 ORX67845.1 - 0.00037 19.8 0.0 0.0011 18.2 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 ORX67845.1 - 0.00065 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 ORX67845.1 - 0.0015 18.1 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 ORX67845.1 - 0.0049 16.6 0.0 0.0087 15.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX67845.1 - 0.0052 17.4 0.0 0.0071 17.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 ORX67845.1 - 0.0077 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.7 ORX67845.1 - 0.028 14.2 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family p450 PF00067.22 ORX67846.1 - 3.3e-70 237.1 0.0 3.9e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CK_II_beta PF01214.18 ORX67847.1 - 5.7e-43 146.8 0.0 9.4e-43 146.1 0.0 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Anoctamin PF04547.12 ORX67848.1 - 1.4e-90 304.3 12.6 1.7e-90 304.0 12.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel MFS_1 PF07690.16 ORX67849.1 - 6.1e-13 48.4 23.3 6.1e-13 48.4 23.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily SelK_SelG PF10961.8 ORX67849.1 - 0.16 12.6 1.0 5.7 7.6 0.3 2.8 2 0 0 2 2 2 0 Selenoprotein SelK_SelG RELT PF12606.8 ORX67849.1 - 0.16 11.0 2.0 0.49 9.4 2.0 1.9 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 ECF-ribofla_trS PF07155.12 ORX67849.1 - 0.24 11.4 14.3 0.37 10.8 0.4 4.4 2 2 2 4 4 4 0 ECF-type riboflavin transporter, S component ABC_membrane PF00664.23 ORX67850.1 - 4.5e-06 26.5 0.0 5.7e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX67851.1 - 1.3e-08 35.5 0.0 2.8e-08 34.4 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 ORX67852.1 - 5.1e-28 98.5 5.7 8.2e-28 97.8 5.7 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX67852.1 - 1.7e-19 70.7 0.0 3.4e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 ORX67852.1 - 0.0016 18.5 0.1 0.0031 17.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX67852.1 - 0.0081 16.6 0.0 0.018 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ORX67852.1 - 0.025 14.3 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX67852.1 - 0.027 14.4 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase MeaB PF03308.16 ORX67852.1 - 0.031 13.3 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SMC_N PF02463.19 ORX67852.1 - 0.21 11.0 0.0 0.92 8.9 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Ebp2 PF05890.12 ORX67853.1 - 1.7e-56 191.8 11.3 2e-56 191.5 11.3 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 EMG1 PF03587.14 ORX67856.1 - 1.9e-76 256.0 0.0 2.3e-76 255.8 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Homeodomain PF00046.29 ORX67858.1 - 1.7e-18 66.2 1.7 2.3e-18 65.8 1.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX67858.1 - 0.0033 17.3 0.0 0.0069 16.3 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 ORX67858.1 - 0.039 13.8 0.1 0.049 13.5 0.1 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT AIG2_2 PF13772.6 ORX67860.1 - 3.2e-05 24.2 0.0 5.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AIG2-like family Mito_carr PF00153.27 ORX67861.1 - 4.2e-21 74.7 0.5 4.8e-14 52.0 0.0 3.5 3 1 0 3 3 3 2 Mitochondrial carrier protein Methyltransf_16 PF10294.9 ORX67862.1 - 1.3e-09 38.0 0.0 1.9e-05 24.5 0.1 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_31 PF13847.6 ORX67862.1 - 5e-06 26.4 0.0 0.051 13.4 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ORX67862.1 - 0.00017 22.2 0.0 0.042 14.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Pmp3 PF01679.17 ORX67862.1 - 0.00037 20.6 0.2 0.00066 19.8 0.2 1.4 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Methyltransf_12 PF08242.12 ORX67862.1 - 0.044 14.5 0.0 0.98 10.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 ORX67862.1 - 0.049 13.2 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX67862.1 - 0.077 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Pmp3 PF01679.17 ORX67863.1 - 8.9e-28 96.2 13.9 2.3e-19 69.3 7.3 2.1 2 0 0 2 2 2 2 Proteolipid membrane potential modulator FYRN PF05964.14 ORX67864.1 - 4.1e-22 77.7 0.8 8.6e-22 76.7 0.8 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 ORX67864.1 - 4.9e-20 71.5 0.0 1.2e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 F/Y rich C-terminus Ino80_Iec3 PF14612.6 ORX67864.1 - 0.012 16.3 1.7 0.033 14.8 1.7 1.7 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Cep57_CLD_2 PF14197.6 ORX67864.1 - 0.02 14.9 3.0 0.052 13.6 3.0 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Filament PF00038.21 ORX67864.1 - 0.033 13.8 1.4 0.048 13.2 1.4 1.1 1 0 0 1 1 1 0 Intermediate filament protein Taxilin PF09728.9 ORX67864.1 - 0.086 12.0 1.0 0.13 11.4 1.0 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Laminin_II PF06009.12 ORX67864.1 - 0.099 12.7 0.4 0.19 11.8 0.4 1.3 1 0 0 1 1 1 0 Laminin Domain II UPF0242 PF06785.11 ORX67864.1 - 0.15 12.2 0.9 0.24 11.5 0.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ERM PF00769.19 ORX67864.1 - 0.53 10.1 7.9 0.042 13.7 3.1 1.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family ZapB PF06005.12 ORX67864.1 - 0.97 9.9 4.0 1.6 9.2 4.0 1.3 1 0 0 1 1 1 0 Cell division protein ZapB TFIIS_C PF01096.18 ORX67866.1 - 3.4e-17 62.0 5.6 3.4e-17 62.0 5.6 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX67866.1 - 1.7e-08 34.2 2.2 1.7e-08 34.2 2.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ORX67866.1 - 0.019 14.9 2.7 0.019 14.9 2.7 2.9 2 2 1 3 3 3 0 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.10 ORX67866.1 - 0.021 14.6 0.6 0.021 14.6 0.6 1.9 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Ribosomal_L1 PF00687.21 ORX67867.1 - 2.8e-46 157.8 0.8 3.2e-46 157.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Myb_DNA-binding PF00249.31 ORX67869.1 - 0.03 14.5 0.0 0.048 13.9 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain Stn1 PF10451.9 ORX67870.1 - 0.0022 17.0 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 RGS PF00615.19 ORX67871.1 - 8.1e-06 26.1 0.0 1.5e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ribosomal_L1 PF00687.21 ORX67872.1 - 2.8e-46 157.8 0.8 3.2e-46 157.6 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family TFIIS_C PF01096.18 ORX67873.1 - 3.4e-17 62.0 5.6 3.4e-17 62.0 5.6 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX67873.1 - 1.7e-08 34.2 2.2 1.7e-08 34.2 2.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ORX67873.1 - 0.019 14.9 2.7 0.019 14.9 2.7 2.9 2 2 1 3 3 3 0 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.10 ORX67873.1 - 0.021 14.6 0.6 0.021 14.6 0.6 1.9 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger PT PF04886.12 ORX67874.1 - 0.018 14.6 0.2 0.032 13.8 0.2 1.4 1 0 0 1 1 1 0 PT repeat DUF229 PF02995.17 ORX67875.1 - 1.3e-42 146.1 0.9 2.7e-40 138.4 0.9 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 ORX67875.1 - 1.4e-08 34.6 0.1 5.7e-08 32.5 0.1 2.0 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ORX67875.1 - 0.00079 19.1 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 ORX67875.1 - 0.064 12.3 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Complex1_LYR_2 PF13233.6 ORX67876.1 - 4.6e-13 49.7 1.0 5.2e-13 49.6 1.0 1.0 1 0 0 1 1 1 1 Complex1_LYR-like P63C PF10546.9 ORX67876.1 - 0.026 15.1 0.3 0.033 14.8 0.3 1.1 1 0 0 1 1 1 0 P63C domain Complex1_LYR PF05347.15 ORX67876.1 - 0.033 14.3 0.4 0.045 13.8 0.4 1.5 1 1 0 1 1 1 0 Complex 1 protein (LYR family) FAD_binding_2 PF00890.24 ORX67877.1 - 3e-87 293.4 9.6 3.4e-87 293.2 9.6 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX67877.1 - 2.6e-11 43.7 8.2 2.5e-10 40.5 5.0 2.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX67877.1 - 4.6e-08 33.2 1.5 2e-07 31.2 0.2 2.8 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX67877.1 - 3.5e-07 29.8 1.0 5e-07 29.3 1.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX67877.1 - 3.8e-06 26.4 2.6 1.5e-05 24.4 2.6 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX67877.1 - 3.1e-05 24.0 0.9 0.055 13.5 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.22 ORX67877.1 - 0.00022 20.5 4.4 0.11 11.6 0.5 2.4 3 0 0 3 3 3 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ORX67877.1 - 0.00025 20.5 6.2 0.0015 17.9 6.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX67877.1 - 0.00059 18.7 5.1 0.028 13.1 0.5 3.0 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 ORX67877.1 - 0.0037 16.4 0.6 0.044 12.8 0.3 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ORX67877.1 - 0.0063 15.8 0.1 0.015 14.6 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain MCRA PF06100.11 ORX67877.1 - 0.011 14.5 0.5 0.027 13.3 0.1 1.7 2 0 0 2 2 2 0 MCRA family Pyr_redox PF00070.27 ORX67877.1 - 0.024 15.2 0.4 2.4 8.8 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX67877.1 - 0.054 12.7 1.4 0.81 8.9 0.1 2.8 3 0 0 3 3 3 0 Thi4 family K_oxygenase PF13434.6 ORX67877.1 - 0.061 12.5 0.5 0.81 8.8 0.1 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 ORX67877.1 - 0.21 10.8 1.0 2.8 7.1 0.2 2.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Y_phosphatase3 PF13350.6 ORX67878.1 - 1.5e-29 103.6 0.0 1.6e-29 103.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ORX67878.1 - 7.5e-06 25.6 0.0 9.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX67878.1 - 0.0076 15.8 0.0 0.0087 15.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX67878.1 - 0.078 13.1 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Rad21_Rec8_N PF04825.13 ORX67880.1 - 2.3e-13 50.3 0.0 5.7e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ORX67880.1 - 1.7e-08 33.6 0.2 5.3e-08 32.0 0.0 1.9 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Amidohydro_1 PF01979.20 ORX67881.1 - 1.6e-09 37.6 0.6 9.2e-09 35.1 0.6 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX67881.1 - 3.8e-05 23.4 0.1 0.00078 19.0 0.0 2.2 2 0 0 2 2 2 1 Amidohydrolase family Glucosamine_iso PF01182.20 ORX67882.1 - 9.8e-21 74.7 0.0 1.6e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AceK PF06315.11 ORX67882.1 - 0.11 11.0 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) MFS_1 PF07690.16 ORX67883.1 - 2.7e-49 168.0 42.4 4.2e-49 167.4 42.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX67883.1 - 3.2e-23 82.0 16.3 3.2e-23 82.0 16.3 2.3 1 1 2 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX67883.1 - 6.3e-12 45.1 14.1 6.3e-12 45.1 14.1 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter SLATT_5 PF18160.1 ORX67883.1 - 0.3 10.4 1.2 0.91 8.8 0.9 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 VacA PF02691.15 ORX67885.1 - 0.21 9.4 0.1 0.29 9.0 0.1 1.1 1 0 0 1 1 1 0 Vacuolating cyotoxin Peptidase_M16 PF00675.20 ORX67886.1 - 2.2e-52 177.0 1.8 3.2e-52 176.5 0.5 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX67886.1 - 1.6e-44 152.1 0.0 1.5e-42 145.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain DnaJ_C PF01556.18 ORX67887.1 - 4.4e-43 146.9 1.0 6.3e-43 146.4 1.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX67887.1 - 4.4e-28 97.2 1.4 7.4e-28 96.5 1.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX67887.1 - 1.1e-14 54.5 20.4 2.1e-14 53.6 20.4 1.5 1 0 0 1 1 1 1 DnaJ central domain Cytochrome_C7 PF14522.6 ORX67887.1 - 0.043 13.8 0.3 0.043 13.8 0.3 2.8 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c HypA PF01155.19 ORX67887.1 - 0.55 10.3 13.5 2.3 8.3 4.9 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrom_CIII PF02085.16 ORX67887.1 - 5.4 7.4 11.5 75 3.7 2.6 3.3 2 1 1 3 3 3 0 Class III cytochrome C family ABC_membrane PF00664.23 ORX67888.1 - 4.1e-94 315.3 22.9 3.4e-67 227.0 6.6 3.2 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX67888.1 - 7.3e-57 191.7 0.0 1.1e-31 110.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX67888.1 - 1.6e-07 31.0 0.9 0.00011 21.7 0.0 3.8 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX67888.1 - 2.8e-05 23.8 1.1 0.27 11.0 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX67888.1 - 5.3e-05 23.5 2.8 0.91 9.8 0.3 3.8 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ORX67888.1 - 6.1e-05 23.5 2.0 0.48 10.8 0.0 3.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 ORX67888.1 - 0.00025 20.8 0.1 0.2 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain G-alpha PF00503.20 ORX67888.1 - 0.00038 19.7 0.0 0.13 11.4 0.0 2.5 2 1 0 2 2 2 1 G-protein alpha subunit DUF87 PF01935.17 ORX67888.1 - 0.00073 19.7 0.6 1.9 8.5 0.1 3.0 3 0 0 3 3 3 2 Helicase HerA, central domain AAA PF00004.29 ORX67888.1 - 0.00082 19.8 0.1 1.5 9.2 0.0 3.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ORX67888.1 - 0.00093 19.1 1.0 2 8.3 0.4 2.7 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 ORX67888.1 - 0.0023 17.2 0.2 1.1 8.5 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.6 ORX67888.1 - 0.0025 17.6 4.6 1.1 9.0 0.1 3.7 4 2 0 4 4 4 2 AAA domain DUF815 PF05673.13 ORX67888.1 - 0.0034 16.6 0.0 2.1 7.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ABC_ATPase PF09818.9 ORX67888.1 - 0.007 15.2 0.2 0.85 8.3 0.1 2.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_5 PF07728.14 ORX67888.1 - 0.013 15.5 0.1 3.8 7.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX67888.1 - 0.013 15.0 0.0 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 ORX67888.1 - 0.014 15.0 0.5 4.9 6.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 ORX67888.1 - 0.014 15.1 1.6 13 5.5 0.0 3.4 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family AAA_15 PF13175.6 ORX67888.1 - 0.032 13.9 0.0 0.15 11.7 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX67888.1 - 0.09 12.9 0.1 19 5.4 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ORX67888.1 - 0.12 12.6 0.2 20 5.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 ORX67888.1 - 0.12 12.3 0.0 0.67 9.8 0.0 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain SbcCD_C PF13558.6 ORX67888.1 - 0.13 12.6 4.6 9 6.6 0.0 3.2 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 ORX67888.1 - 0.25 11.1 1.6 43 3.8 0.2 3.5 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system IF-2B PF01008.17 ORX67889.1 - 1.2e-60 205.2 0.1 2.3e-30 105.8 0.0 2.7 2 1 0 2 2 2 2 Initiation factor 2 subunit family HSA PF07529.13 ORX67889.1 - 0.009 16.3 1.3 0.009 16.3 1.3 3.4 4 0 0 4 4 4 1 HSA Rubredoxin_2 PF18073.1 ORX67889.1 - 0.19 11.4 2.0 0.34 10.7 2.0 1.3 1 0 0 1 1 1 0 Rubredoxin metal binding domain Lipase_3 PF01764.25 ORX67890.1 - 1.1e-37 129.0 0.0 1.8e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX67890.1 - 0.022 14.3 0.0 0.14 11.7 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 ORX67890.1 - 0.026 14.0 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PCI PF01399.27 ORX67891.1 - 3.7e-18 66.0 0.4 7.7e-18 64.9 0.4 1.5 1 0 0 1 1 1 1 PCI domain RPN6_C_helix PF18503.1 ORX67891.1 - 1.4e-11 43.9 0.5 3.3e-11 42.7 0.5 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_7 PF13176.6 ORX67891.1 - 0.001 19.0 0.3 2.3 8.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX67891.1 - 0.069 13.3 1.4 10 6.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PEP-utilisers_N PF05524.13 ORX67891.1 - 0.093 12.9 1.2 0.17 12.1 0.5 1.8 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal RPN7 PF10602.9 ORX67892.1 - 5.1e-41 140.3 0.1 8.5e-41 139.5 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ORX67892.1 - 1.2e-13 51.4 0.0 3.7e-13 49.9 0.0 1.9 1 0 0 1 1 1 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 ORX67892.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family zf-C2H2 PF00096.26 ORX67893.1 - 6.2e-18 64.2 9.1 3.2e-05 24.1 0.3 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX67893.1 - 1.9e-09 37.5 18.0 6.5e-05 23.2 0.4 4.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX67893.1 - 1.1e-08 35.1 9.1 0.034 15.0 0.4 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 ORX67893.1 - 0.0025 18.1 1.6 2.2 8.8 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 ORX67893.1 - 0.0082 16.3 7.3 2.8 8.1 0.2 3.1 1 1 1 3 3 3 2 Aberrant zinc-finger Ima1_N PF09779.9 ORX67893.1 - 0.064 14.1 2.1 0.087 13.7 1.2 1.6 2 0 0 2 2 2 0 Ima1 N-terminal domain DUF717 PF05338.12 ORX67893.1 - 0.097 12.8 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF717) zf-C2H2_3rep PF18868.1 ORX67893.1 - 0.1 13.2 4.8 1.8 9.3 1.5 3.0 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 ORX67893.1 - 0.28 11.8 10.9 3.9 8.2 0.0 4.0 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX67893.1 - 2.4 8.3 7.5 6.2 6.9 0.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Thioredoxin_8 PF13905.6 ORX67895.1 - 1.6e-10 41.2 0.0 2.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 ORX67895.1 - 0.013 15.4 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_6 PF13848.6 ORX67895.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DAHP_synth_2 PF01474.16 ORX67898.1 - 1.9e-176 586.9 0.0 1.6e-168 560.7 0.0 2.0 1 1 1 2 2 2 2 Class-II DAHP synthetase family Sulfatase PF00884.23 ORX67899.1 - 5.9e-37 127.7 1.1 2.6e-36 125.6 1.1 1.8 1 1 0 1 1 1 1 Sulfatase Sulfatase PF00884.23 ORX67900.1 - 4.4e-43 147.8 0.8 5.8e-43 147.5 0.8 1.1 1 0 0 1 1 1 1 Sulfatase ADH_N PF08240.12 ORX67901.1 - 1.5e-24 85.9 1.1 1.5e-24 85.9 1.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX67901.1 - 5.6e-18 65.2 0.0 1.1e-17 64.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX67901.1 - 3.4e-07 29.8 0.0 5.3e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ORX67901.1 - 1.4e-06 29.4 0.0 4.9e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX67901.1 - 5.2e-06 25.9 0.0 9.8e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 ORX67901.1 - 0.026 14.3 0.1 0.048 13.4 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GFO_IDH_MocA PF01408.22 ORX67901.1 - 0.06 14.2 0.0 0.14 12.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ADH_N PF08240.12 ORX67902.1 - 9.5e-24 83.4 2.5 9.5e-24 83.4 2.5 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX67902.1 - 3e-17 62.8 0.2 5e-17 62.1 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX67902.1 - 2.6e-05 23.7 0.2 5.4e-05 22.6 0.2 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX67902.1 - 0.0016 17.8 0.4 0.0026 17.1 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 ORX67902.1 - 0.0048 16.6 0.1 0.008 15.9 0.1 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Keratin_matx PF04579.12 ORX67902.1 - 0.04 14.3 0.2 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 Keratin, high-sulphur matrix protein Oxidored_nitro PF00148.19 ORX67902.1 - 0.062 12.0 0.0 0.11 11.1 0.0 1.4 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase EMP24_GP25L PF01105.24 ORX67903.1 - 2.3e-26 92.8 0.0 2.7e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DHHC PF01529.20 ORX67904.1 - 3.4e-32 111.4 10.7 3.4e-32 111.4 10.7 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_4 PF13637.6 ORX67904.1 - 7.1e-18 64.7 0.0 7e-07 29.7 0.0 4.1 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX67904.1 - 1.5e-12 46.5 0.2 0.0045 17.4 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_2 PF12796.7 ORX67904.1 - 2.9e-11 43.8 0.2 7.6e-05 23.2 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX67904.1 - 2.8e-10 40.2 0.0 0.0027 18.0 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX67904.1 - 3.1e-08 33.7 0.0 0.0068 16.8 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat SelP_N PF04592.14 ORX67904.1 - 0.026 14.0 3.6 0.051 13.0 3.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AMP-binding PF00501.28 ORX67905.1 - 7e-23 80.9 0.0 2.1e-22 79.4 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme Pox_C7_F8A PF03287.14 ORX67905.1 - 0.015 15.3 0.1 0.026 14.5 0.1 1.3 1 0 0 1 1 1 0 Poxvirus C7/F8A protein PSII_BNR PF14870.6 ORX67905.1 - 0.097 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 Peripla_BP_2 PF01497.18 ORX67906.1 - 3.6e-08 33.2 0.0 0.00064 19.3 0.1 2.2 1 1 1 2 2 2 2 Periplasmic binding protein RRG8 PF17068.5 ORX67906.1 - 0.019 14.4 0.3 0.025 14.0 0.3 1.1 1 0 0 1 1 1 0 Required for respiratory growth protein 8 mitochondrial Bap31 PF05529.12 ORX67908.1 - 3.1e-37 127.4 2.0 3.1e-37 127.4 2.0 1.3 1 1 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 ORX67908.1 - 1.1e-06 28.5 7.3 1.5e-06 28.1 7.3 1.2 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Uso1_p115_C PF04871.13 ORX67908.1 - 0.041 14.2 6.1 0.053 13.9 6.1 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region YabA PF06156.13 ORX67908.1 - 0.23 12.1 2.6 0.35 11.5 2.6 1.3 1 0 0 1 1 1 0 Initiation control protein YabA GrpE PF01025.19 ORX67908.1 - 0.24 11.1 5.2 0.39 10.4 5.2 1.3 1 0 0 1 1 1 0 GrpE tRNA_anti-codon PF01336.25 ORX67909.1 - 5.3e-06 26.3 0.1 6.9e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 ORX67909.1 - 0.13 12.4 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Sulfatase PF00884.23 ORX67910.1 - 2.4e-52 178.3 1.8 2.9e-52 178.0 1.8 1.1 1 0 0 1 1 1 1 Sulfatase ELO PF01151.18 ORX67911.1 - 5.1e-14 52.4 31.6 6.8e-10 38.9 22.6 2.8 1 1 0 2 2 2 2 GNS1/SUR4 family TMEM135_C_rich PF15982.5 ORX67911.1 - 0.059 14.0 3.7 0.093 13.3 3.7 1.4 1 0 0 1 1 1 0 N-terminal cysteine-rich region of Transmembrane protein 135 Sterol_MT_C PF08498.10 ORX67911.1 - 0.55 10.6 3.2 2.7 8.3 1.0 2.4 2 0 0 2 2 2 0 Sterol methyltransferase C-terminal Aldo_ket_red PF00248.21 ORX67912.1 - 3.8e-23 82.1 0.1 7.8e-18 64.7 0.0 3.9 1 1 1 2 2 2 2 Aldo/keto reductase family Aldo_ket_red PF00248.21 ORX67913.1 - 2.1e-44 151.9 0.0 2.7e-42 145.0 0.0 2.7 1 1 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S6 PF01250.17 ORX67914.1 - 1.6e-18 66.8 0.0 1.8e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Porin_3 PF01459.22 ORX67915.1 - 3.5e-42 144.7 0.2 4.1e-42 144.5 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin Recep_L_domain PF01030.24 ORX67916.1 - 4.2e-09 36.5 9.9 0.021 14.9 4.0 4.5 2 2 2 4 4 4 3 Receptor L domain LRR_4 PF12799.7 ORX67916.1 - 0.27 11.7 14.3 4.1 8.0 0.2 5.7 4 2 1 5 5 5 0 Leucine Rich repeats (2 copies) Usp PF00582.26 ORX67917.1 - 5.1e-05 23.8 0.0 9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family TFIIB_C_1 PF18542.1 ORX67917.1 - 0.021 14.9 0.3 0.054 13.5 0.2 1.7 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 BCAS2 PF05700.11 ORX67917.1 - 0.077 12.7 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) tRNA-synt_1b PF00579.25 ORX67918.1 - 3.1e-62 210.5 0.0 3.1e-61 207.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Kelch_4 PF13418.6 ORX67919.1 - 1.9e-15 56.6 4.7 1.5e-05 24.9 0.1 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX67919.1 - 2.9e-08 33.7 2.9 0.11 12.8 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ORX67919.1 - 1.5e-07 31.6 7.5 0.35 11.2 0.2 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX67919.1 - 1.3e-06 27.8 3.1 0.019 14.6 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ORX67919.1 - 2e-06 27.6 4.4 0.11 12.5 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ORX67919.1 - 3.8e-06 26.7 0.9 0.038 14.0 0.0 4.6 4 0 0 4 4 4 2 Kelch motif SdpI PF13630.6 ORX67919.1 - 0.082 13.0 0.8 0.17 12.0 0.8 1.5 1 0 0 1 1 1 0 SdpI/YhfL protein family MoeA_N PF03453.17 ORX67920.1 - 2.3e-39 134.7 4.4 3.6e-39 134.0 4.4 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 ORX67920.1 - 7.7e-36 122.9 2.5 1.6e-16 60.3 0.1 4.4 2 2 1 3 3 3 3 Probable molybdopterin binding domain MoeA_C PF03454.15 ORX67920.1 - 3.2e-10 40.1 0.0 8.9e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) HMG_box PF00505.19 ORX67921.1 - 4.1e-33 113.6 7.7 2.7e-16 59.7 1.0 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX67921.1 - 7.1e-22 77.8 6.5 8.8e-11 42.2 0.4 2.5 2 0 0 2 2 2 2 HMG-box domain Ccdc124 PF06244.12 ORX67921.1 - 0.23 12.0 5.4 6.7 7.3 0.1 3.0 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 124 /Oxs1 COX4 PF02936.14 ORX67921.1 - 0.35 10.9 2.9 0.78 9.8 0.2 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 ORX67921.1 - 0.48 10.9 12.0 0.73 10.3 5.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Protamine_like PF06382.11 ORX67921.1 - 0.63 10.2 6.6 0.79 9.9 0.2 2.5 2 1 0 2 2 2 0 Protamine and protamine like ArsA_ATPase PF02374.15 ORX67922.1 - 2.5e-95 319.2 1.1 2.8e-95 319.0 1.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 ORX67922.1 - 0.028 14.3 0.1 0.094 12.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain BALF1 PF06861.11 ORX67922.1 - 0.09 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 BALF1 protein FGGY_N PF00370.21 ORX67924.1 - 1.9e-74 250.3 0.0 2.6e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ORX67924.1 - 4.2e-70 235.5 0.2 7.6e-70 234.7 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Eno-Rase_FAD_bd PF07055.12 ORX67924.1 - 0.11 13.0 0.8 0.56 10.7 0.2 2.3 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Chitin_synth_2 PF03142.15 ORX67926.1 - 1.9e-221 736.3 6.9 2.3e-219 729.4 6.9 2.1 1 1 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX67926.1 - 2.6e-09 37.3 0.0 5e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX67926.1 - 8e-08 32.4 5.3 3e-07 30.6 5.3 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX67926.1 - 0.006 16.1 0.1 0.064 12.7 0.0 2.3 3 0 0 3 3 3 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX67926.1 - 0.063 13.1 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 Nudix_N_2 PF14803.6 ORX67926.1 - 1.3 9.0 4.0 17 5.4 0.4 2.9 2 0 0 2 2 2 0 Nudix N-terminal TFIIA PF03153.13 ORX67927.1 - 4.9e-45 155.3 1.3 5.9e-45 155.0 1.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit JmjC PF02373.22 ORX67928.1 - 4.6e-28 97.9 0.1 9.7e-28 96.9 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 ORX67928.1 - 5.1e-21 75.1 0.1 1.2e-20 74.0 0.1 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PLU-1 PF08429.11 ORX67928.1 - 5.2e-21 75.2 1.1 5.2e-21 75.2 1.1 2.7 3 1 0 3 3 3 1 PLU-1-like protein JmjN PF02375.17 ORX67928.1 - 2.1e-16 59.6 3.5 2.1e-16 59.6 3.5 2.0 2 0 0 2 2 2 1 jmjN domain zf-C5HC2 PF02928.16 ORX67928.1 - 8.2e-13 48.5 7.6 8.2e-13 48.5 7.6 2.5 3 0 0 3 3 3 1 C5HC2 zinc finger PHD PF00628.29 ORX67928.1 - 5.7e-11 42.1 6.3 5.7e-11 42.1 6.3 2.8 3 0 0 3 3 3 2 PHD-finger Zf_RING PF16744.5 ORX67928.1 - 0.15 12.2 9.1 0.18 11.9 0.6 2.9 2 0 0 2 2 2 0 KIAA1045 RING finger Msg2_C PF12373.8 ORX67928.1 - 0.16 11.4 0.0 0.47 9.9 0.0 1.8 1 0 0 1 1 1 0 Major surface glycoprotein 2 C terminal zf-RING_2 PF13639.6 ORX67928.1 - 0.26 11.7 19.7 0.18 12.1 5.3 3.1 2 0 0 2 2 2 0 Ring finger domain CDC45 PF02724.14 ORX67928.1 - 1.5 7.0 5.2 2.6 6.2 5.2 1.2 1 0 0 1 1 1 0 CDC45-like protein PHD PF00628.29 ORX67929.1 - 2.1e-05 24.3 7.3 2.3e-05 24.2 3.5 2.1 2 0 0 2 2 2 1 PHD-finger PHD_4 PF16866.5 ORX67929.1 - 0.24 11.5 8.2 0.82 9.8 8.2 1.8 1 1 0 1 1 1 0 PHD-finger Glyco_hydro_15 PF00723.21 ORX67931.1 - 1.6e-105 353.5 0.0 2.4e-105 352.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 ILEI PF15711.5 ORX67931.1 - 6.3e-09 36.2 0.0 7e-08 32.8 0.0 2.6 1 1 0 1 1 1 1 Interleukin-like EMT inducer NUDIX PF00293.28 ORX67932.1 - 2.2e-10 40.7 0.0 3.2e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 ORX67933.1 - 9.8e-12 45.0 0.2 1.7e-11 44.3 0.1 1.5 1 1 0 1 1 1 1 NUDIX domain Pyridoxal_deC PF00282.19 ORX67934.1 - 4.1e-109 364.7 0.0 5.4e-109 364.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 ORX67934.1 - 0.0061 15.8 0.1 0.013 14.6 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II DUF3291 PF11695.8 ORX67934.1 - 0.16 11.7 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) Glyco_hydro81C PF17652.1 ORX67935.1 - 2.1e-38 132.5 6.8 2.3e-18 66.6 0.2 3.2 2 1 1 3 3 3 3 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 ORX67935.1 - 4.6e-22 78.6 0.3 5.3e-10 39.0 0.0 3.3 1 1 2 3 3 3 3 Glycosyl hydrolase family 81 N-terminal domain PRIMA1 PF16101.5 ORX67935.1 - 8.4 6.5 6.9 16 5.6 6.9 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CN_hydrolase PF00795.22 ORX67938.1 - 6.9e-61 205.9 0.0 7.9e-61 205.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ARID PF01388.21 ORX67940.1 - 1.5e-13 51.2 0.0 6.3e-13 49.2 0.0 2.2 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Oxysterol_BP PF01237.18 ORX67941.1 - 1.3e-39 136.2 1.7 3.9e-34 118.1 0.1 3.7 1 1 1 2 2 2 2 Oxysterol-binding protein Myb_DNA-bind_4 PF13837.6 ORX67941.1 - 0.013 15.8 0.1 0.032 14.6 0.1 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Raffinose_syn PF05691.12 ORX67942.1 - 4.2e-36 124.1 4.5 1.4e-33 115.7 4.5 2.1 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 DUF3641 PF12345.8 ORX67943.1 - 0.069 13.2 0.4 0.11 12.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) RPN2_C PF18004.1 ORX67943.1 - 0.17 11.8 1.3 0.23 11.4 1.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 ORX67943.1 - 0.33 9.0 1.8 0.37 8.8 1.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ORX67943.1 - 0.36 10.5 2.4 0.48 10.1 2.4 1.3 1 0 0 1 1 1 0 FAM176 family HSP70 PF00012.20 ORX67944.1 - 2.3e-248 825.3 11.9 2.7e-248 825.1 11.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX67944.1 - 1.7e-19 69.8 0.3 1.6e-17 63.3 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 ORX67944.1 - 0.0027 18.1 4.1 2.4 8.6 0.1 3.8 3 2 0 3 3 3 2 Cell division protein FtsA DDR PF08841.10 ORX67944.1 - 0.029 13.4 0.2 0.27 10.2 0.1 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 ORX67944.1 - 0.043 13.6 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 ORX67944.1 - 0.6 9.3 10.9 0.042 13.1 5.8 1.6 2 0 0 2 2 2 0 Radial spoke protein 3 DUF4473 PF14747.6 ORX67944.1 - 3.5 8.2 11.3 9.6 6.8 1.3 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4473) RRS1 PF04939.12 ORX67945.1 - 6.5e-56 188.7 3.1 6.5e-56 188.7 3.1 2.2 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) DUF4384 PF14326.6 ORX67946.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) p450 PF00067.22 ORX67947.1 - 9e-58 196.1 0.0 1.1e-57 195.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Exog_C PF18026.1 ORX67947.1 - 0.21 11.6 0.0 3.7 7.7 0.0 2.5 2 1 1 3 3 3 0 Endo/exonuclease (EXOG) C-terminal domain zf-RING_2 PF13639.6 ORX67949.1 - 1.1e-09 38.4 13.5 1.9e-09 37.7 13.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX67949.1 - 3.8e-09 36.1 6.6 3.8e-09 36.1 6.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX67949.1 - 1.4e-05 25.3 11.0 3.4e-05 24.0 11.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX67949.1 - 1.6e-05 24.7 12.4 2.5e-05 24.0 12.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX67949.1 - 3.4e-05 23.6 11.8 0.00024 20.9 12.6 1.9 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX67949.1 - 4.8e-05 23.3 6.2 0.00012 22.1 6.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX67949.1 - 9e-05 22.4 9.0 9.6e-05 22.3 5.6 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX67949.1 - 0.00062 19.7 10.2 0.00099 19.0 10.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX67949.1 - 0.0071 16.2 9.9 0.012 15.4 9.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX67949.1 - 0.062 13.2 9.0 0.19 11.6 9.0 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ORX67949.1 - 0.11 12.1 10.2 0.22 11.1 10.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX67949.1 - 3.8 7.7 11.2 8 6.7 11.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 ORX67949.1 - 8.8 6.5 13.3 96 3.2 13.1 2.7 1 1 1 2 2 2 0 RING-variant domain 5_nucleotid PF05761.14 ORX67950.1 - 3.5e-126 421.8 0.1 4.1e-126 421.6 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 ORX67950.1 - 0.015 15.4 0.1 0.22 11.6 0.0 2.8 4 0 0 4 4 4 0 Haloacid dehalogenase-like hydrolase C5-epim_C PF06662.13 ORX67950.1 - 0.039 13.4 0.1 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus zf-CCCH PF00642.24 ORX67952.1 - 0.0021 17.9 2.7 0.0036 17.2 2.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ORX67952.1 - 0.031 15.0 0.2 0.077 13.7 0.2 1.6 1 0 0 1 1 1 0 Torus domain zf_CCCH_4 PF18345.1 ORX67952.1 - 0.045 13.8 4.4 0.076 13.1 4.4 1.4 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH_4 PF18044.1 ORX67952.1 - 0.05 13.4 3.1 0.084 12.7 3.1 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger HAUS5 PF14817.6 ORX67954.1 - 9.8e-07 27.9 2.2 9.8e-07 27.9 2.2 1.5 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 5 KLRAQ PF10205.9 ORX67954.1 - 0.00038 20.7 1.0 0.001 19.3 1.0 1.7 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein GerPC PF10737.9 ORX67954.1 - 0.013 15.6 0.3 0.013 15.6 0.3 1.6 2 0 0 2 2 2 0 Spore germination protein GerPC DivIC PF04977.15 ORX67954.1 - 3.3 7.5 9.6 3.7 7.4 4.1 2.5 2 0 0 2 2 2 0 Septum formation initiator Trypsin PF00089.26 ORX67955.1 - 2.2e-30 106.2 0.4 2.5e-30 106.0 0.4 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX67955.1 - 0.00041 21.3 0.1 0.00082 20.3 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Slu7 PF11708.8 ORX67956.1 - 6.8e-81 271.9 11.5 1.6e-67 228.1 1.1 2.3 1 1 1 2 2 2 2 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 ORX67956.1 - 0.068 12.9 0.6 0.15 11.8 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle Carn_acyltransf PF00755.20 ORX67957.1 - 4.1e-127 425.3 0.0 1.4e-75 255.1 0.0 3.2 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase HpcH_HpaI PF03328.14 ORX67958.1 - 2.9e-48 163.9 1.5 3.4e-48 163.7 1.5 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 ORX67958.1 - 1.5e-10 40.8 0.1 4.2e-08 32.7 0.0 2.2 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.21 ORX67958.1 - 6.9e-05 21.9 0.2 8.7e-05 21.6 0.2 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain CMAS PF02353.20 ORX67959.1 - 3.4e-60 203.7 0.1 4.4e-60 203.3 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ORX67959.1 - 2.8e-09 37.6 0.0 9.2e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX67959.1 - 3.1e-07 30.9 0.0 6.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX67959.1 - 3.4e-07 30.2 0.0 6.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX67959.1 - 0.0001 22.9 0.0 0.00018 22.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 ORX67959.1 - 0.003 17.1 0.0 0.0072 15.9 0.0 1.5 2 0 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 ORX67959.1 - 0.0035 16.9 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ORX67959.1 - 0.057 13.2 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 ORX67959.1 - 0.12 12.3 0.0 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Rad51 PF08423.11 ORX67960.1 - 9.9e-12 44.7 0.1 1.3e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_33 PF13671.6 ORX67960.1 - 0.011 15.9 0.1 0.037 14.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX67960.1 - 0.033 14.6 0.1 0.05 14.0 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 ORX67960.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 ORX67960.1 - 0.071 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX67960.1 - 0.076 13.3 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ORX67960.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Z1 PF10593.9 ORX67962.1 - 0.1 12.1 0.5 0.34 10.4 0.1 1.8 2 0 0 2 2 2 0 Z1 domain Chlorosome_CsmC PF11098.8 ORX67962.1 - 0.13 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Chlorosome envelope protein C PMEI PF04043.15 ORX67962.1 - 0.18 12.2 3.7 0.75 10.1 3.7 1.9 1 1 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Pre-SET PF05033.16 ORX67963.1 - 0.019 15.6 0.5 0.037 14.7 0.5 1.4 1 0 0 1 1 1 0 Pre-SET motif F-box-like PF12937.7 ORX67964.1 - 0.0039 17.1 0.1 0.0095 15.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like USP7_ICP0_bdg PF12436.8 ORX67965.1 - 2e-05 24.0 0.0 3.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 NIF PF03031.18 ORX67966.1 - 1.6e-48 164.4 0.2 2.2e-48 163.9 0.2 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Methyltransf_32 PF13679.6 ORX67967.1 - 3.8e-27 95.2 0.3 6.4e-27 94.5 0.3 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX67967.1 - 0.016 15.9 0.1 0.071 13.8 0.2 2.2 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 ORX67967.1 - 0.036 13.9 0.1 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain KTI12 PF08433.10 ORX67968.1 - 2.2e-63 214.3 0.0 5.6e-61 206.4 0.0 2.0 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ORX67968.1 - 0.012 15.7 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SKIP_SNW PF02731.15 ORX67969.1 - 1.2e-18 67.3 20.9 1.2e-18 67.3 20.9 3.7 2 1 0 2 2 2 1 SKIP/SNW domain UbiA PF01040.18 ORX67970.1 - 1.7e-61 207.7 23.6 2.2e-61 207.4 23.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family HMA PF00403.26 ORX67971.1 - 2.1e-49 165.8 11.5 4.1e-13 49.6 0.0 6.3 5 2 0 5 5 5 5 Heavy-metal-associated domain Hydrolase PF00702.26 ORX67971.1 - 5.5e-38 131.4 1.0 5.7e-37 128.0 0.2 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX67971.1 - 2.9e-35 121.4 2.3 2.9e-35 121.4 2.3 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX67971.1 - 8.1e-05 22.5 1.2 0.00015 21.6 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX67971.1 - 0.019 15.4 0.1 0.054 13.9 0.1 1.8 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DAHP_snth_FXD PF18152.1 ORX67971.1 - 0.053 13.4 1.5 20 5.1 0.0 3.5 3 0 0 3 3 3 0 DAHP synthase ferredoxin-like domain RTA1 PF04479.13 ORX67972.1 - 8.1e-12 45.2 8.3 1.6e-11 44.2 8.3 1.4 1 1 0 1 1 1 1 RTA1 like protein DUF5453 PF17534.2 ORX67972.1 - 0.046 13.7 1.1 0.072 13.1 0.7 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5453) RTA1 PF04479.13 ORX67973.1 - 7.9e-10 38.7 3.9 7.9e-10 38.7 3.9 1.5 2 0 0 2 2 2 1 RTA1 like protein Tim17 PF02466.19 ORX67973.1 - 0.75 10.2 7.1 0.76 10.2 0.6 2.5 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family DUF3995 PF13160.6 ORX67973.1 - 1.3 9.4 13.8 0.16 12.3 4.4 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF3995) MCM PF00493.23 ORX67974.1 - 1.6e-78 262.9 0.7 1.2e-39 135.7 0.5 2.3 1 1 1 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 ORX67974.1 - 1.6e-38 131.4 0.3 4.9e-38 129.8 0.2 1.9 2 0 0 2 2 2 1 MCM OB domain MCM6_C PF18263.1 ORX67974.1 - 2.9e-23 82.2 0.2 6.3e-23 81.1 0.2 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 ORX67974.1 - 2.8e-21 75.7 0.3 1.6e-20 73.3 0.0 2.3 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ORX67974.1 - 8e-12 45.7 0.0 2.5e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX67974.1 - 0.0092 15.4 0.0 0.18 11.2 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF3074 PF11274.8 ORX67975.1 - 1.6e-15 57.5 0.0 1.3e-11 44.8 0.0 2.3 1 1 0 2 2 2 2 Protein of unknown function (DUF3074) SUN PF03856.13 ORX67976.1 - 2.6e-62 210.5 12.9 4.1e-62 209.8 12.9 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) ABC_tran PF00005.27 ORX67977.1 - 2.9e-43 147.7 0.0 5.7e-26 91.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX67977.1 - 1.6e-06 28.0 1.5 1.6e-06 28.0 1.5 2.2 3 0 0 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX67977.1 - 7.8e-06 25.5 0.4 0.95 8.9 0.0 3.3 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX67977.1 - 0.0001 22.3 0.3 0.008 16.3 0.0 3.6 3 0 0 3 3 3 1 50S ribosome-binding GTPase DUF87 PF01935.17 ORX67977.1 - 0.0077 16.3 0.0 0.025 14.7 0.0 1.8 2 0 0 2 2 2 1 Helicase HerA, central domain T2SSE PF00437.20 ORX67977.1 - 0.015 14.4 0.2 0.69 8.9 0.1 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 ORX67977.1 - 0.018 15.4 0.0 1.2 9.5 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 ORX67977.1 - 0.058 13.5 1.2 5.4 7.1 0.0 2.9 3 0 0 3 3 3 0 Dynamin family AAA_21 PF13304.6 ORX67977.1 - 0.065 13.0 0.1 0.92 9.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX67977.1 - 0.17 12.2 0.1 5.2 7.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 ORX67977.1 - 0.76 9.6 3.3 1.8 8.4 0.2 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AA_permease_2 PF13520.6 ORX67978.1 - 1.4e-54 185.6 37.3 1.8e-54 185.2 37.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX67978.1 - 1.2e-38 133.0 34.7 5.7e-38 130.7 36.0 1.4 1 1 1 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 ORX67978.1 - 9.3e-05 22.4 3.4 9.3e-05 22.4 3.4 4.6 6 0 0 6 6 6 1 C-terminus of AA_permease MFS_1 PF07690.16 ORX67979.1 - 5.5e-39 134.1 54.3 1.3e-38 132.9 51.4 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX67979.1 - 1.9e-15 56.3 17.2 1.9e-15 56.3 17.2 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX67979.1 - 6.3e-13 48.4 31.6 4.1e-11 42.4 13.9 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter Pribosyltran PF00156.27 ORX67980.1 - 9.2e-08 31.8 0.0 1.5e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Dus PF01207.17 ORX67982.1 - 2.7e-57 194.2 0.0 4e-57 193.7 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 ORX67982.1 - 2.5e-08 33.5 12.6 1e-05 25.2 0.1 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH PF00642.24 ORX67982.1 - 2e-05 24.4 10.0 0.0053 16.6 0.1 3.0 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX67982.1 - 0.013 15.5 13.1 0.021 14.9 1.0 3.1 2 1 1 3 3 3 0 Zinc finger domain zf-CCCH_2 PF14608.6 ORX67982.1 - 0.031 14.7 8.5 0.14 12.6 0.3 3.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX67982.1 - 0.62 10.8 4.3 0.28 11.9 1.2 2.0 1 1 1 2 2 2 0 Torus domain Amidase_5 PF05382.13 ORX67983.1 - 0.019 14.9 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage peptidoglycan hydrolase MIP PF00230.20 ORX67984.1 - 1.1e-41 143.0 11.7 1.3e-41 142.8 11.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein Lys_export PF03956.13 ORX67984.1 - 0.16 11.5 6.2 0.17 11.4 3.2 2.2 3 0 0 3 3 3 0 Lysine exporter LysO Mod_r PF07200.13 ORX67985.1 - 1.4e-25 90.1 6.7 1.7e-25 89.8 6.7 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein TMF_DNA_bd PF12329.8 ORX67985.1 - 0.015 15.3 0.3 0.048 13.7 0.3 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding MIT_C PF16565.5 ORX67985.1 - 0.084 12.9 0.3 0.28 11.2 0.3 1.7 1 1 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT CLZ PF16526.5 ORX67985.1 - 0.14 12.5 2.4 0.57 10.6 0.6 2.7 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cep57_MT_bd PF06657.13 ORX67985.1 - 0.25 11.8 4.5 7.4 7.1 0.2 3.3 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ChAPs PF09295.10 ORX67987.1 - 7.9e-118 393.9 0.0 2.2e-58 198.1 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 ORX67987.1 - 0.00012 22.0 5.5 0.052 13.7 0.4 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX67987.1 - 0.0019 18.7 0.6 5.2 7.6 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX67987.1 - 0.091 13.6 8.8 4.3 8.4 0.1 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 ORX67987.1 - 0.13 12.5 0.4 12 6.2 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX67987.1 - 0.29 11.8 5.2 14 6.4 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX67987.1 - 0.85 10.0 8.6 14 6.2 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 ORX67987.1 - 5.5 6.1 11.0 1.5 7.9 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Tubulin PF00091.25 ORX67988.1 - 4.1e-71 239.2 0.0 6.4e-71 238.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX67988.1 - 5.8e-43 146.1 0.5 9.5e-43 145.4 0.5 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX67988.1 - 0.00011 22.5 0.0 0.00038 20.7 0.0 1.9 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ORX67988.1 - 0.002 17.8 0.0 0.017 14.8 0.0 2.1 2 0 0 2 2 2 1 Tubulin domain Hrs_helical PF12210.8 ORX67988.1 - 0.16 12.6 1.0 0.24 12.0 0.2 1.6 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Josephin PF02099.17 ORX67989.1 - 2.9e-25 89.3 0.0 7.5e-25 87.9 0.0 1.7 1 1 0 1 1 1 1 Josephin DUF1911 PF08929.10 ORX67989.1 - 3.8 8.4 6.6 8 7.3 0.3 3.4 2 2 2 4 4 4 0 Domain of unknown function (DUF1911) Arrestin_N PF00339.29 ORX67992.1 - 9.4e-15 54.9 0.0 2.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Sec7 PF01369.20 ORX67995.1 - 3.4e-65 219.2 0.1 1.6e-64 217.0 0.1 2.1 2 0 0 2 2 2 1 Sec7 domain DUF1981 PF09324.10 ORX67995.1 - 1.9e-30 104.5 0.6 1e-24 86.2 0.0 4.9 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) Sec7_N PF12783.7 ORX67995.1 - 6.7e-24 84.6 0.6 3e-23 82.5 0.6 2.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal FAM76 PF16046.5 ORX67999.1 - 0.0011 18.4 7.1 0.0011 18.4 7.1 1.6 2 0 0 2 2 2 1 FAM76 protein Spt20 PF12090.8 ORX67999.1 - 0.4 10.3 29.3 0.11 12.1 23.4 2.2 2 0 0 2 2 2 0 Spt20 family Plasmodium_Vir PF05795.11 ORX67999.1 - 1.4 8.3 6.5 0.12 11.8 2.1 1.5 2 0 0 2 2 2 0 Plasmodium vivax Vir protein CTU2 PF10288.9 ORX67999.1 - 1.6 9.0 13.5 0.33 11.2 8.8 2.3 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 SpoIIP PF07454.11 ORX67999.1 - 1.8 8.0 7.5 3.8 6.9 7.5 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 ORX67999.1 - 5.4 5.7 12.8 0.22 10.2 6.1 1.9 2 0 0 2 2 2 0 Presenilin p450 PF00067.22 ORX68000.1 - 6.3e-74 249.4 0.0 7.9e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4499 PF14934.6 ORX68001.1 - 2.8e-05 24.3 0.8 7.5e-05 23.0 0.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4499) ADH_zinc_N PF00107.26 ORX68002.1 - 9.4e-16 58.0 0.6 1.3e-15 57.5 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX68002.1 - 8.7e-09 35.2 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX68002.1 - 0.011 16.7 0.0 0.021 15.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase V-SNARE_C PF12352.8 ORX68003.1 - 2.3e-14 53.4 2.0 1.6e-13 50.7 0.1 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ORX68003.1 - 4.5e-05 23.3 2.1 0.00022 21.1 0.0 2.6 3 0 0 3 3 3 1 Sec20 Focal_AT PF03623.13 ORX68003.1 - 0.00046 20.2 3.6 0.00092 19.2 3.6 1.5 1 0 0 1 1 1 1 Focal adhesion targeting region Ring_hydroxyl_B PF00866.18 ORX68003.1 - 0.002 18.2 1.6 0.0065 16.5 1.5 1.8 2 0 0 2 2 2 1 Ring hydroxylating beta subunit THOC7 PF05615.13 ORX68003.1 - 3.3 8.0 10.8 8.3 6.7 10.8 1.7 1 1 0 1 1 1 0 Tho complex subunit 7 Pantoate_transf PF02548.15 ORX68004.1 - 7.5e-106 353.3 3.7 9e-106 353.0 3.7 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 ORX68004.1 - 1.8e-05 24.3 0.1 3.1e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase FGGY_N PF00370.21 ORX68005.1 - 4.2e-23 82.2 0.0 3.3e-21 76.0 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ORX68005.1 - 5.1e-18 65.5 0.1 9.6e-18 64.6 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Sod_Cu PF00080.20 ORX68006.1 - 4.4e-27 95.0 0.8 1.6e-26 93.2 0.1 1.9 2 0 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.26 ORX68006.1 - 3.8e-10 40.1 0.0 6.2e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain SH3_2 PF07653.17 ORX68007.1 - 1.2e-10 40.9 0.1 2.2e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX68007.1 - 1.8e-06 27.7 0.0 3.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX68007.1 - 3.7e-06 26.4 0.1 7.4e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain DUF2205 PF10224.9 ORX68007.1 - 0.0028 17.6 0.7 0.0028 17.6 0.7 3.6 2 1 2 4 4 4 1 Short coiled-coil protein DUF1664 PF07889.12 ORX68007.1 - 0.054 13.5 5.9 0.045 13.8 3.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 ORX68007.1 - 0.056 13.0 8.2 0.12 11.9 8.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2884 PF11101.8 ORX68007.1 - 0.49 9.9 10.7 0.48 9.9 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) FlaC_arch PF05377.11 ORX68007.1 - 0.58 10.6 2.4 24 5.4 0.1 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4715 PF15835.5 ORX68007.1 - 1.1 9.3 6.4 2.2 8.4 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) WXG100 PF06013.12 ORX68007.1 - 1.6 9.0 7.9 3 8.1 5.9 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TMPIT PF07851.13 ORX68007.1 - 5.1 6.2 4.9 9.8 5.3 4.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 ORX68007.1 - 5.6 7.7 7.0 38 5.0 0.1 3.0 1 1 1 2 2 2 0 Initiation control protein YabA LPP PF04728.13 ORX68007.1 - 5.9 7.4 6.9 56 4.2 3.9 2.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper zf-C2H2_2 PF12756.7 ORX68008.1 - 4.8e-37 126.3 12.1 2.9e-31 107.8 0.8 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX68008.1 - 6e-13 48.7 9.8 3.1e-08 33.7 5.7 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX68008.1 - 3.7e-10 39.8 10.0 1.2e-08 35.0 3.6 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type AKAP95 PF04988.12 ORX68008.1 - 0.0067 16.7 12.8 0.069 13.4 6.5 3.1 1 1 2 3 3 3 2 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_6 PF13912.6 ORX68008.1 - 0.013 15.5 1.4 0.013 15.5 1.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX68008.1 - 0.034 15.0 0.3 0.034 15.0 0.3 4.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-BED PF02892.15 ORX68008.1 - 0.97 9.5 7.4 0.31 11.1 0.3 3.2 3 1 0 3 3 3 0 BED zinc finger Rota_VP2 PF05087.12 ORX68008.1 - 3.8 5.5 11.0 5.2 5.1 11.0 1.2 1 0 0 1 1 1 0 Rotavirus VP2 protein Cpn60_TCP1 PF00118.24 ORX68009.1 - 9.5e-166 552.2 0.2 1.2e-165 551.9 0.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 ORX68010.1 - 3.2e-13 49.9 0.7 0.049 14.5 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX68010.1 - 6e-05 23.3 0.0 0.1 12.9 0.0 3.5 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ORX68010.1 - 0.12 10.3 0.0 0.14 10.1 0.0 1.1 1 0 0 1 1 1 0 IKI3 family Glyco_hydro_20 PF00728.22 ORX68011.1 - 2.1e-22 80.0 0.4 4.2e-20 72.4 0.4 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 ORX68011.1 - 2.8e-21 76.6 0.2 1.4e-20 74.4 0.2 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Laminin_G_3 PF13385.6 ORX68011.1 - 3.9e-08 33.6 2.4 7.3e-08 32.7 0.6 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_67N PF03648.14 ORX68011.1 - 0.017 15.4 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus HTH_30 PF13556.6 ORX68012.1 - 0.0021 17.8 0.2 0.013 15.3 0.2 2.0 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain Tim44 PF04280.15 ORX68013.1 - 4.3e-34 117.7 1.3 5.5e-34 117.4 0.1 1.8 2 0 0 2 2 2 1 Tim44-like domain Coatomer_g_Cpla PF16381.5 ORX68013.1 - 1.2 9.2 7.1 1.2 9.3 2.7 2.4 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform Ribosomal_S14 PF00253.21 ORX68014.1 - 3.2e-23 81.2 0.1 6.7e-23 80.2 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Cauli_VI PF01693.16 ORX68014.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Caulimovirus viroplasmin AAA-ATPase_like PF09820.9 ORX68015.1 - 8.8e-09 35.2 0.1 3.5e-08 33.2 0.1 1.9 1 1 0 1 1 1 1 Predicted AAA-ATPase ABC_membrane PF00664.23 ORX68016.1 - 4.2e-40 138.1 13.0 5.5e-40 137.7 13.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX68016.1 - 6.2e-35 120.7 0.0 1.3e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68016.1 - 4.6e-06 26.2 0.1 0.00099 18.6 0.0 2.6 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX68016.1 - 0.00049 20.5 0.0 0.0017 18.8 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX68016.1 - 0.0035 17.6 0.0 0.025 14.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ORX68016.1 - 0.0042 16.9 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ORX68016.1 - 0.0059 17.0 0.0 0.11 12.9 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ORX68016.1 - 0.024 14.4 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX68016.1 - 0.03 14.8 0.1 0.17 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ORX68016.1 - 0.032 14.0 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ORX68016.1 - 0.035 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF5538 PF17692.1 ORX68016.1 - 0.042 13.9 1.2 0.095 12.8 1.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5538) DUF3526 PF12040.8 ORX68016.1 - 0.076 13.5 1.4 0.19 12.2 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3526) DUF629 PF04780.12 ORX68016.1 - 0.11 11.0 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) AAA_33 PF13671.6 ORX68016.1 - 0.13 12.5 0.4 1.2 9.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ORX68016.1 - 0.15 12.2 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase TPR_11 PF13414.6 ORX68016.1 - 0.19 11.4 2.0 0.4 10.4 1.1 2.0 2 0 0 2 2 2 0 TPR repeat TPR_1 PF00515.28 ORX68016.1 - 3.5 7.6 5.9 2.3 8.2 3.4 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RTA1 PF04479.13 ORX68017.1 - 3.2e-07 30.2 9.9 5.9e-07 29.3 4.0 2.7 1 1 1 2 2 2 2 RTA1 like protein TssN PF17555.2 ORX68017.1 - 1.4 8.3 7.5 1.4 8.2 1.4 2.1 1 1 0 2 2 2 0 Type VI secretion system, TssN F-box-like PF12937.7 ORX68018.1 - 0.089 12.7 1.2 0.13 12.1 0.2 1.9 2 0 0 2 2 2 0 F-box-like Ribonuc_2-5A PF06479.12 ORX68018.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease 2-5A DUF3738 PF12543.8 ORX68018.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) M20_dimer PF07687.14 ORX68018.1 - 0.14 12.1 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 Peptidase dimerisation domain Gpr1_Fun34_YaaH PF01184.19 ORX68020.1 - 1.7e-48 165.0 19.0 5.8e-28 97.9 7.2 2.3 1 1 1 2 2 2 2 GPR1/FUN34/yaaH family UPF0054 PF02130.17 ORX68022.1 - 3.6e-21 75.3 0.0 3.8e-21 75.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 DTHCT PF08070.11 ORX68023.1 - 0.012 16.4 2.5 0.012 16.4 2.5 1.7 2 0 0 2 2 2 0 DTHCT (NUC029) region Aldo_ket_red PF00248.21 ORX68024.1 - 4.4e-27 95.0 0.0 9.8e-27 93.9 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family ABC_tran PF00005.27 ORX68025.1 - 2e-42 144.9 0.0 9.6e-29 100.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX68025.1 - 4.9e-19 69.0 3.6 1.7e-14 54.2 0.3 3.9 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX68025.1 - 0.00046 19.7 0.0 0.0035 16.8 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX68025.1 - 0.08 13.0 0.0 0.28 11.3 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase MeaB PF03308.16 ORX68025.1 - 0.12 11.3 0.1 0.2 10.6 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 ORX68025.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein zf-C2H2_4 PF13894.6 ORX68026.1 - 0.022 15.6 0.1 0.022 15.6 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX68026.1 - 0.029 14.4 0.4 0.094 12.7 0.1 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX68026.1 - 0.067 13.7 0.1 0.067 13.7 0.1 1.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX68027.1 - 0.05 14.5 0.4 0.05 14.5 0.4 2.5 2 1 1 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 ORX68027.1 - 0.073 13.2 4.0 4.8 7.4 0.8 2.5 2 1 0 2 2 2 0 Zinc ribbon domain FYVE PF01363.21 ORX68027.1 - 3.1 8.0 7.6 1.8e+02 2.3 7.6 2.3 1 1 0 1 1 1 0 FYVE zinc finger Sec63 PF02889.16 ORX68028.1 - 2.4e-67 226.8 0.0 1.7e-50 171.6 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain Helicase_PWI PF18149.1 ORX68028.1 - 5e-17 62.1 0.2 1.8e-16 60.3 0.0 2.1 2 0 0 2 2 2 1 N-terminal helicase PWI domain Helicase_C PF00271.31 ORX68028.1 - 2.8e-13 50.2 0.0 4.1e-12 46.4 0.0 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX68028.1 - 7.2e-13 48.7 0.1 1e-11 44.9 0.1 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX68028.1 - 9e-07 29.0 0.1 2.7e-05 24.2 0.0 3.1 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX68028.1 - 0.01 16.1 1.1 0.033 14.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain OPT PF03169.15 ORX68030.1 - 1.2e-148 496.5 50.5 1.5e-148 496.2 50.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 ORX68030.1 - 0.21 10.9 0.9 0.65 9.3 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3093 PF11292.8 ORX68030.1 - 0.25 11.6 3.0 2 8.7 3.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) CDO_I PF05995.12 ORX68031.1 - 4.6e-45 153.0 0.0 6e-45 152.6 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 ORX68031.1 - 3.4e-05 23.4 0.1 0.0016 17.9 0.1 2.2 1 1 0 1 1 1 1 PCO_ADO Prenyltransf PF01255.19 ORX68032.1 - 1.5e-71 240.5 0.0 1.8e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase SHP PF03579.13 ORX68032.1 - 0.16 12.0 0.3 0.32 11.0 0.3 1.5 1 0 0 1 1 1 0 Small hydrophobic protein ANAPC4_WD40 PF12894.7 ORX68033.1 - 2.8e-08 34.0 0.2 0.0027 18.0 0.0 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX68033.1 - 8.9e-06 26.4 0.1 0.26 12.2 0.0 4.7 4 1 1 5 5 5 1 WD domain, G-beta repeat Lactonase PF10282.9 ORX68033.1 - 0.0037 16.6 0.3 0.089 12.0 0.0 2.7 2 1 0 3 3 3 1 Lactonase, 7-bladed beta-propeller PQQ_2 PF13360.6 ORX68033.1 - 0.027 14.1 0.3 0.057 13.0 0.3 1.5 1 1 0 1 1 1 0 PQQ-like domain Sial-lect-inser PF09264.10 ORX68033.1 - 0.063 13.0 0.0 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 Vibrio cholerae sialidase, lectin insertion PK PF00224.21 ORX68035.1 - 8.1e-157 521.5 1.4 1.1e-156 521.1 1.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ORX68035.1 - 2.3e-38 131.0 0.1 8.6e-38 129.2 0.0 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ORX68035.1 - 5.7e-07 28.9 0.5 1.7e-06 27.3 0.5 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DUF218 PF02698.17 ORX68035.1 - 0.099 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 DUF218 domain RNB PF00773.19 ORX68036.1 - 4.3e-53 180.7 0.1 7.3e-52 176.7 0.1 2.4 1 1 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 ORX68036.1 - 3e-07 30.3 0.0 6.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 S1 domain FIST_C PF10442.9 ORX68036.1 - 0.1 12.6 0.1 0.36 10.8 0.1 1.9 1 0 0 1 1 1 0 FIST C domain INSIG PF07281.12 ORX68037.1 - 1.2e-19 70.8 4.2 5.1e-19 68.8 4.2 2.0 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) DUF1729 PF08354.10 ORX68038.1 - 6e-107 357.6 0.1 4.7e-77 259.3 0.0 3.3 1 1 1 2 2 2 2 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX68038.1 - 2.6e-67 226.2 0.1 8.2e-67 224.6 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX68038.1 - 1.1e-44 152.6 0.1 2.2e-44 151.5 0.1 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Acyl_transf_1 PF00698.21 ORX68038.1 - 1.2e-44 153.2 0.0 1.6e-43 149.5 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain FAS_meander PF17951.1 ORX68038.1 - 7.6e-35 119.9 0.0 1.6e-34 118.8 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain FAS_N PF17828.1 ORX68038.1 - 7e-23 81.0 0.1 1.5e-22 79.9 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 ORX68038.1 - 2.7e-14 52.8 0.1 6.8e-14 51.5 0.1 1.6 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 ORX68038.1 - 1.4e-13 51.1 0.0 8.9e-13 48.5 0.0 2.4 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 ORX68038.1 - 3.3e-08 33.7 0.0 1.1e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase ketoacyl-synt PF00109.26 ORX68038.1 - 5.2e-05 22.9 0.5 0.00022 20.9 0.4 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX68038.1 - 0.00017 21.6 0.1 0.00061 19.8 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 ORX68038.1 - 0.057 12.9 0.0 0.16 11.4 0.0 1.8 1 0 0 1 1 1 0 short chain dehydrogenase Velvet PF11754.8 ORX68039.1 - 7.4e-67 225.9 0.6 8.7e-67 225.7 0.6 1.0 1 0 0 1 1 1 1 Velvet factor PQ-loop PF04193.14 ORX68040.1 - 4.9e-31 106.3 19.8 1.8e-17 62.9 1.8 3.0 3 1 1 4 4 4 2 PQ loop repeat DUF1516 PF07457.11 ORX68040.1 - 0.17 12.1 1.3 0.32 11.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) MutS_V PF00488.21 ORX68041.1 - 5.9e-71 238.4 0.1 1e-70 237.6 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX68041.1 - 7.8e-31 107.8 0.3 1.8e-30 106.6 0.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 ORX68041.1 - 1.8e-10 41.2 0.0 4.7e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 ORX68041.1 - 4.7e-08 33.3 0.0 1.5e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 ORX68041.1 - 0.00012 22.4 0.1 0.019 15.3 0.0 2.6 1 1 1 2 2 2 2 MutS family domain IV AAA_27 PF13514.6 ORX68041.1 - 0.1 12.2 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSppdC PF12528.8 ORX68043.1 - 0.03 15.1 0.6 0.13 13.0 0.1 1.9 1 1 1 2 2 2 0 Type II secretion prepilin peptidase dependent protein C WD40 PF00400.32 ORX68044.1 - 1.8e-29 101.3 18.5 1.4e-07 32.1 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat PFU PF09070.11 ORX68044.1 - 5.7e-27 94.2 0.4 1.2e-26 93.1 0.4 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 ORX68044.1 - 2.5e-17 63.0 0.1 2.1e-11 43.6 0.0 2.2 1 1 1 2 2 2 2 PUL domain Med6 PF04934.14 ORX68045.1 - 6.7e-41 139.2 0.0 7.4e-41 139.1 0.0 1.0 1 0 0 1 1 1 1 MED6 mediator sub complex component tRNA-synt_2 PF00152.20 ORX68046.1 - 1.4e-91 306.9 0.0 2.2e-91 306.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX68046.1 - 1.5e-10 40.9 0.0 3.1e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_His PF13393.6 ORX68046.1 - 1.8 7.8 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Histidyl-tRNA synthetase Cellulase PF00150.18 ORX68047.1 - 2.5e-05 23.9 0.1 0.02 14.3 0.0 2.5 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) PIP5K PF01504.18 ORX68047.1 - 0.24 10.6 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Cellulase PF00150.18 ORX68048.1 - 1.3e-13 51.0 1.0 2.1e-13 50.3 1.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RNase_H2_suC PF08615.11 ORX68048.1 - 4.9e-10 39.7 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Rad10 PF03834.14 ORX68049.1 - 1.6e-40 137.7 0.0 3.1e-40 136.8 0.0 1.5 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 ORX68049.1 - 4.2e-09 36.9 0.1 1.2e-08 35.4 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 ORX68049.1 - 4.4e-07 29.9 0.0 1.6e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH PF00633.23 ORX68049.1 - 0.0003 20.5 0.0 0.00075 19.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif TM1506 PF08973.10 ORX68049.1 - 0.0015 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1893) Pdase_M17_N2 PF18295.1 ORX68049.1 - 0.037 14.3 0.1 0.077 13.3 0.1 1.6 1 0 0 1 1 1 0 M17 aminopeptidase N-terminal domain 2 HhH-GPD PF00730.25 ORX68049.1 - 0.087 13.3 0.0 0.3 11.6 0.0 1.9 2 0 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein FTR1 PF03239.14 ORX68050.1 - 7.1e-59 199.5 12.7 5.8e-57 193.2 12.7 2.1 1 1 0 1 1 1 1 Iron permease FTR1 family Wzy_C PF04932.15 ORX68050.1 - 0.028 14.0 0.7 0.028 14.0 0.7 2.9 3 1 0 3 3 3 0 O-Antigen ligase DUF5534 PF17686.1 ORX68050.1 - 0.85 9.8 1.9 2.5 8.3 1.9 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5534) DUF2070 PF09843.9 ORX68050.1 - 1.4 7.1 8.9 0.19 10.0 2.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF1043 PF06295.12 ORX68050.1 - 2.6 8.1 8.9 0.41 10.7 1.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) MgtE PF01769.16 ORX68050.1 - 4.5 7.7 17.8 0.21 12.0 1.7 3.2 3 1 0 3 3 3 0 Divalent cation transporter Cu-oxidase_2 PF07731.14 ORX68051.1 - 3.9e-35 120.6 12.4 1.9e-32 111.9 5.9 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX68051.1 - 7.3e-27 93.8 8.8 2.1e-26 92.3 0.2 3.9 4 1 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX68051.1 - 3.5e-23 82.5 3.8 4.4e-18 65.9 0.0 3.9 4 0 0 4 4 4 2 Multicopper oxidase AMP-binding PF00501.28 ORX68052.1 - 1.1e-84 284.5 1.7 1.1e-82 278.0 1.7 2.0 1 1 0 1 1 1 1 AMP-binding enzyme Arrestin_N PF00339.29 ORX68053.1 - 1.3e-09 38.2 0.0 2.6e-08 34.0 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX68053.1 - 0.0039 16.9 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like Trypsin PF00089.26 ORX68054.1 - 3.2e-36 125.2 1.3 3.8e-36 125.0 0.5 1.5 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.6 ORX68054.1 - 0.0045 17.9 0.1 0.0091 16.9 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain adh_short PF00106.25 ORX68056.1 - 3.3e-09 36.5 0.1 7.7e-05 22.2 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX68056.1 - 0.00014 21.5 0.0 0.0029 17.2 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ABC_tran PF00005.27 ORX68057.1 - 3.1e-28 99.0 0.0 5.1e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX68057.1 - 3.5e-27 95.7 13.3 4.7e-27 95.3 13.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX68057.1 - 2.7e-05 23.7 0.0 0.00055 19.4 0.2 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ORX68057.1 - 0.0027 16.8 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ORX68057.1 - 0.0079 16.5 0.7 0.1 12.9 0.7 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX68057.1 - 0.029 13.9 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ORX68057.1 - 0.15 12.4 0.0 0.4 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF5422 PF17459.2 ORX68057.1 - 0.19 11.9 3.9 0.14 12.3 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5422) ABC_tran PF00005.27 ORX68090.1 - 2.8e-19 70.0 0.0 5.1e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX68090.1 - 0.00013 21.8 8.8 0.0095 15.6 0.6 2.7 2 1 0 2 2 2 2 ABC transporter transmembrane region MMR_HSR1 PF01926.23 ORX68090.1 - 0.096 12.8 0.2 0.3 11.2 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATPase PF06745.13 ORX68090.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC SMC_N PF02463.19 ORX68090.1 - 0.13 11.7 0.8 6.9 6.0 0.2 2.9 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 ORX68091.1 - 8.1e-21 74.9 1.7 8.1e-21 74.9 1.7 2.6 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX68091.1 - 3e-11 44.0 0.0 8.4e-11 42.5 0.0 1.8 1 1 0 1 1 1 1 ABC transporter HBD PF18534.1 ORX68091.1 - 0.088 12.9 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Helical bundle domain Transferase PF02458.15 ORX68093.1 - 2.4e-15 56.2 0.0 6e-13 48.2 0.0 2.3 2 0 0 2 2 2 2 Transferase family Trypsin PF00089.26 ORX68095.1 - 2.8e-30 105.8 0.2 3.3e-30 105.5 0.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX68095.1 - 2.7e-05 25.1 0.0 3.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain TGT PF01702.18 ORX68096.1 - 2.7e-144 480.6 0.0 3.2e-144 480.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Nod1 PF17114.5 ORX68096.1 - 0.18 12.0 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Gef2-related medial cortical node protein Nod1 Zn_clus PF00172.18 ORX68097.1 - 1.7e-08 34.4 15.5 2.4e-08 33.9 15.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Roughex PF06020.11 ORX68097.1 - 5.4 6.0 6.0 0.22 10.6 0.5 1.6 2 0 0 2 2 2 0 Drosophila roughex protein adh_short_C2 PF13561.6 ORX68098.1 - 1.1e-31 110.2 0.1 6.7e-27 94.6 0.2 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX68098.1 - 7.5e-25 87.5 0.0 3.1e-16 59.4 0.1 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 ORX68098.1 - 0.0055 16.6 1.0 2.3 8.1 0.1 2.2 1 1 1 2 2 2 2 KR domain DUF1776 PF08643.10 ORX68098.1 - 0.0057 16.1 0.0 0.0081 15.6 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) PTP_N PF12453.8 ORX68098.1 - 0.36 10.6 1.5 3.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase N terminal Peptidase_M3 PF01432.20 ORX68099.1 - 5.4e-94 316.0 0.0 1.6e-93 314.5 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M3 NDK PF00334.19 ORX68100.1 - 3.9e-49 166.1 0.0 5.7e-49 165.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF4350 PF14258.6 ORX68100.1 - 0.15 12.5 0.5 0.95 9.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) p450 PF00067.22 ORX68101.1 - 3.4e-62 210.7 0.0 4.5e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sgf11_N PF18519.1 ORX68108.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 SAGA-associated factor 11 N-terminal domain Ras PF00071.22 ORX68109.1 - 7.6e-20 71.1 0.0 9.5e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX68109.1 - 0.00032 20.9 0.1 0.0012 19.0 0.0 1.8 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LtrA PF06772.11 ORX68111.1 - 5.4e-33 114.7 19.3 7.3e-33 114.2 19.3 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) LtrA PF06772.11 ORX68112.1 - 1.2e-29 103.6 23.4 1.8e-29 103.1 23.4 1.3 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Exc PF07825.11 ORX68112.1 - 0.12 12.4 0.3 3.8 7.6 0.1 2.5 2 0 0 2 2 2 0 Excisionase-like protein DUF2011 PF09428.10 ORX68113.1 - 0.0013 18.9 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Abhydrolase_1 PF00561.20 ORX68114.1 - 1.7e-17 63.9 0.0 4.4e-16 59.3 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 ORX68114.1 - 4e-17 61.5 0.1 1e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 ORX68114.1 - 0.012 14.9 0.0 0.033 13.5 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ORX68114.1 - 0.14 11.0 0.0 0.66 8.8 0.0 1.9 2 0 0 2 2 2 0 Chlorophyllase enzyme K_channel_TID PF07941.11 ORX68114.1 - 8.5 6.9 5.3 16 6.1 5.3 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain CorA PF01544.18 ORX68116.1 - 9.5e-37 126.9 2.1 1.2e-36 126.5 2.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2358 PF10184.9 ORX68116.1 - 0.099 12.9 0.1 0.32 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) HVSL PF09749.9 ORX68118.1 - 4.6e-27 95.0 0.0 4.9e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 ORX68118.1 - 0.0077 16.1 0.0 0.0084 16.0 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily ABC_membrane PF00664.23 ORX68120.1 - 3.2e-57 194.3 26.6 4.1e-37 128.3 8.3 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX68120.1 - 5.9e-46 156.4 0.0 1.4e-26 93.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX68120.1 - 1.5e-09 37.6 4.9 0.00095 18.7 0.2 4.9 5 1 0 6 6 5 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 ORX68120.1 - 3.2e-07 30.1 0.5 0.014 15.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 ORX68120.1 - 3e-06 27.9 0.3 0.0043 17.6 0.1 2.4 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ORX68120.1 - 8.5e-05 22.5 0.1 0.045 13.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ORX68120.1 - 0.0001 22.0 0.1 0.15 11.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX68120.1 - 0.00018 21.6 0.7 0.073 13.2 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 ORX68120.1 - 0.0002 20.5 0.6 0.19 10.7 0.2 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 ORX68120.1 - 0.00036 21.0 0.4 1.3 9.3 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ORX68120.1 - 0.0024 17.8 0.9 1.5 8.6 0.2 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 ORX68120.1 - 0.0031 16.8 0.0 0.39 10.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin TrwB_AAD_bind PF10412.9 ORX68120.1 - 0.0085 15.0 2.1 0.73 8.7 0.1 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 ORX68120.1 - 0.012 15.4 1.4 3.7 7.2 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_22 PF13401.6 ORX68120.1 - 0.014 15.7 3.6 9.7 6.5 0.2 3.4 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 ORX68120.1 - 0.031 14.7 2.2 0.77 10.2 0.1 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX68120.1 - 0.031 14.0 1.2 8 6.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 ORX68120.1 - 0.1 12.3 0.0 3.9 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 ORX68120.1 - 0.1 12.1 0.4 15 5.0 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ORX68120.1 - 0.18 12.2 0.1 14 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 ORX68120.1 - 0.21 11.7 1.9 0.61 10.1 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Adeno_IVa2 PF02456.15 ORX68120.1 - 0.25 10.1 0.8 0.49 9.1 0.2 1.7 2 0 0 2 2 2 0 Adenovirus IVa2 protein NACHT PF05729.12 ORX68120.1 - 0.67 9.8 3.0 1.6 8.6 0.6 2.4 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 ORX68120.1 - 0.92 9.1 3.3 5.4 6.6 0.8 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TAP42 PF04177.12 ORX68122.1 - 7.1e-84 281.6 8.4 8e-84 281.5 8.4 1.0 1 0 0 1 1 1 1 TAP42-like family Spectrin_like PF18373.1 ORX68122.1 - 0.15 12.2 1.2 3.6 7.7 0.0 2.8 2 0 0 2 2 2 0 Spectrin like domain MFS_1 PF07690.16 ORX68123.1 - 9.1e-32 110.3 18.5 9.1e-32 110.3 18.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily BTD PF09270.10 ORX68124.1 - 3.6e-10 40.3 0.1 9.5e-09 35.7 0.0 2.2 2 0 0 2 2 2 1 Beta-trefoil DNA-binding domain C12orf66_like PF09404.10 ORX68128.1 - 1.9e-06 27.0 0.2 0.016 14.1 0.0 4.0 4 0 0 4 4 4 3 KICSTOR complex C12orf66 like Granulin PF00396.18 ORX68130.1 - 5.3 7.5 16.3 0.43 10.9 0.6 4.0 2 2 2 4 4 4 0 Granulin Lustrin_cystein PF14625.6 ORX68130.1 - 8.7 6.8 27.6 5.4 7.5 1.0 3.9 1 1 2 3 3 3 0 Lustrin, cysteine-rich repeated domain Methyltransf_12 PF08242.12 ORX68131.1 - 2.8e-15 56.8 0.0 2.3e-14 53.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX68131.1 - 1.9e-13 50.9 0.0 3.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX68131.1 - 4.9e-13 49.3 0.0 7.1e-13 48.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX68131.1 - 1.9e-10 41.2 0.0 3.6e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX68131.1 - 7.7e-07 29.0 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX68131.1 - 4.2e-05 23.2 0.0 7.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.17 ORX68131.1 - 0.035 13.3 0.3 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 ORX68131.1 - 0.13 13.3 0.0 0.27 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Tim17 PF02466.19 ORX68132.1 - 4.6e-34 117.1 8.8 6.3e-34 116.7 8.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family AAA PF00004.29 ORX68133.1 - 2.4e-59 199.5 0.0 4.8e-44 150.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX68133.1 - 2.6e-11 43.1 0.3 8.6e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX68133.1 - 8.7e-10 39.2 4.7 0.0039 17.6 0.2 3.9 2 2 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 ORX68133.1 - 5.2e-07 29.9 0.0 0.0093 16.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 ORX68133.1 - 2.6e-06 27.3 0.0 0.00014 21.7 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX68133.1 - 3.6e-06 27.0 0.1 0.079 13.0 0.0 3.4 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) TsaE PF02367.17 ORX68133.1 - 0.00012 22.0 0.0 0.5 10.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ORX68133.1 - 0.00065 20.3 0.3 0.23 12.0 0.0 3.0 4 0 0 4 4 2 1 AAA domain Mg_chelatase PF01078.21 ORX68133.1 - 0.00071 19.0 0.5 0.027 13.8 0.1 3.1 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ORX68133.1 - 0.00072 18.9 0.0 0.021 14.0 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 ORX68133.1 - 0.0011 19.3 1.1 0.13 12.6 0.1 3.7 2 2 2 4 4 4 1 AAA domain IstB_IS21 PF01695.17 ORX68133.1 - 0.0017 18.1 0.1 0.033 13.9 0.1 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX68133.1 - 0.002 18.5 0.0 0.11 13.0 0.0 2.5 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 ORX68133.1 - 0.0026 17.7 0.6 2.4 8.1 0.1 3.4 4 0 0 4 4 3 1 NACHT domain AAA_28 PF13521.6 ORX68133.1 - 0.0038 17.5 0.2 0.57 10.4 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX68133.1 - 0.0044 16.8 0.5 4.5 6.9 0.0 3.3 3 1 0 3 3 3 1 AAA domain Parvo_NS1 PF01057.17 ORX68133.1 - 0.0048 16.0 0.0 0.013 14.7 0.0 1.6 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 ORX68133.1 - 0.0062 16.1 0.0 0.35 10.4 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_11 PF13086.6 ORX68133.1 - 0.011 15.6 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 ORX68133.1 - 0.012 15.8 0.0 0.23 11.5 0.0 2.9 3 1 0 3 3 3 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ORX68133.1 - 0.019 14.1 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_6 PF12774.7 ORX68133.1 - 0.027 13.4 0.0 1.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 ORX68133.1 - 0.028 14.1 0.0 3.4 7.4 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 ORX68133.1 - 0.039 13.7 0.3 12 5.6 0.0 2.7 3 0 0 3 3 2 0 Cytidylate kinase PhoH PF02562.16 ORX68133.1 - 0.049 13.1 0.1 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.11 ORX68133.1 - 0.054 13.4 0.0 5 7.0 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ORX68133.1 - 0.12 12.3 0.0 20 5.0 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 ORX68133.1 - 0.15 11.7 2.2 1.5 8.4 0.0 3.4 4 0 0 4 4 4 0 AAA domain AAA_17 PF13207.6 ORX68133.1 - 0.17 12.3 0.0 1.1 9.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.6 ORX68133.1 - 0.18 11.9 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase-like family ATPase PF06745.13 ORX68133.1 - 0.22 10.8 0.3 0.5 9.7 0.0 1.6 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 ORX68133.1 - 0.23 10.7 0.0 1.5 8.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Nucleoside_tran PF01733.18 ORX68135.1 - 6e-40 137.5 1.0 1.2e-39 136.6 1.0 1.5 1 0 0 1 1 1 1 Nucleoside transporter DUF2569 PF10754.9 ORX68135.1 - 0.19 12.2 7.9 0.087 13.3 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Lactamase_B_6 PF16661.5 ORX68136.1 - 7.9e-08 32.0 0.1 1.8e-07 30.8 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain zf-AN1 PF01428.16 ORX68137.1 - 2.7e-21 75.4 34.7 2.4e-11 43.6 10.1 3.2 4 0 0 4 4 4 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 ORX68137.1 - 1.7e-07 31.4 20.2 1.9e-05 24.9 5.4 2.6 3 0 0 3 3 3 2 Tc5 transposase C-terminal domain HABP4_PAI-RBP1 PF04774.15 ORX68138.1 - 0.0043 17.9 15.7 0.0043 17.9 15.7 3.1 2 2 0 2 2 2 1 Hyaluronan / mRNA binding family SMBP PF16785.5 ORX68138.1 - 3.8 7.8 9.3 0.86 9.8 1.4 2.7 2 1 1 3 3 3 0 Small metal-binding protein CMS1 PF14617.6 ORX68139.1 - 3.1e-18 66.0 7.3 4.6e-17 62.2 0.2 2.4 2 1 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit CHAP PF05257.16 ORX68139.1 - 1.6e-05 25.4 3.0 1.6e-05 25.4 3.0 1.8 2 0 0 2 2 2 1 CHAP domain DEAD PF00270.29 ORX68139.1 - 0.00052 19.8 0.0 0.0009 19.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase SH3_3 PF08239.11 ORX68140.1 - 0.001 19.3 0.2 0.0022 18.2 0.2 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Phage_lysozyme PF00959.19 ORX68140.1 - 0.039 14.4 0.4 1.3 9.5 0.2 2.3 1 1 1 2 2 2 0 Phage lysozyme PhoLip_ATPase_C PF16212.5 ORX68142.1 - 1.1e-71 241.5 28.6 6.4e-67 225.9 17.2 3.0 2 1 1 3 3 3 2 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX68142.1 - 6.7e-28 96.2 3.0 1.7e-27 94.9 3.0 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX68142.1 - 3.7e-11 43.0 0.0 1.3e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX68142.1 - 8.7e-11 42.5 0.4 2e-05 25.0 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX68142.1 - 1.2e-10 41.2 1.8 1.4e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX68142.1 - 0.0068 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase MMM1 PF10296.9 ORX68144.1 - 1.7e-06 27.4 0.0 2.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 ORX68144.1 - 0.0098 16.4 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 1 PH domain DcuC PF03606.15 ORX68144.1 - 0.048 12.1 0.1 0.075 11.5 0.1 1.2 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier PH_11 PF15413.6 ORX68144.1 - 0.1 13.0 0.0 0.33 11.4 0.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain PSP PF04046.16 ORX68145.1 - 1.6e-11 43.9 0.0 3.9e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.23 ORX68145.1 - 0.0067 16.5 0.8 0.012 15.6 0.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 ORX68145.1 - 0.18 11.6 0.2 0.33 10.7 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Acetyltransf_3 PF13302.7 ORX68146.1 - 9.2e-11 42.6 0.1 5.2e-10 40.1 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX68146.1 - 0.00013 22.2 0.0 0.00018 21.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Proteasome PF00227.26 ORX68147.1 - 1.5e-33 115.9 1.7 1.8e-19 69.9 0.1 2.5 2 1 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 ORX68147.1 - 1.1e-15 56.9 0.1 2.3e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Nucleoside_tran PF01733.18 ORX68148.1 - 7.7e-14 51.8 7.8 1.4e-10 41.0 1.9 2.1 1 1 1 2 2 2 2 Nucleoside transporter CAP_N PF01213.19 ORX68150.1 - 0.081 12.4 2.0 0.14 11.6 2.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LRR_8 PF13855.6 ORX68151.1 - 6.3e-44 147.6 56.5 5e-09 35.8 0.0 9.4 5 2 3 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 ORX68151.1 - 1.5e-32 111.1 67.2 0.00011 22.6 2.3 11.9 8 3 3 13 13 13 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX68151.1 - 6.2e-11 41.3 48.6 8.2 7.4 0.0 17.0 18 1 0 18 18 18 2 Leucine Rich Repeat LRR_9 PF14580.6 ORX68151.1 - 1.8e-06 27.6 24.1 8.4e-05 22.1 2.4 4.8 2 1 0 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 ORX68151.1 - 0.3 11.2 63.9 2.4 8.5 0.4 15.1 17 0 0 17 17 17 0 Leucine Rich repeat Guanylate_cyc PF00211.20 ORX68152.1 - 1.1e-26 93.6 0.0 1.7e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ribosomal_S5_C PF03719.15 ORX68155.1 - 1.5e-26 91.6 0.0 1.2e-24 85.5 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 ORX68155.1 - 9.5e-08 31.9 5.9 8.2e-06 25.7 5.9 2.3 1 1 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF1934 PF09148.10 ORX68155.1 - 0.12 12.4 0.2 0.2 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1934) Arm PF00514.23 ORX68156.1 - 6.7e-34 114.9 24.6 1.3e-07 31.4 0.0 8.8 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX68156.1 - 6.8e-07 29.6 8.9 0.002 18.5 2.3 5.0 1 1 6 7 7 7 4 HEAT repeats KAP PF05804.12 ORX68156.1 - 0.00016 20.0 0.0 0.018 13.2 0.0 2.4 1 1 2 3 3 3 3 Kinesin-associated protein (KAP) HEAT_EZ PF13513.6 ORX68156.1 - 0.0029 18.1 10.1 0.13 12.8 0.4 5.8 5 2 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 ORX68156.1 - 0.0035 17.5 11.9 8.3 7.0 0.0 7.0 8 0 0 8 8 8 1 HEAT repeat WAPL PF07814.13 ORX68156.1 - 0.015 14.1 1.4 0.04 12.7 0.3 2.1 2 0 0 2 2 2 0 Wings apart-like protein regulation of heterochromatin Arm_2 PF04826.13 ORX68156.1 - 0.023 14.1 7.5 0.2 11.1 0.9 3.3 1 1 2 3 3 3 0 Armadillo-like Vac14_Fab1_bd PF12755.7 ORX68156.1 - 0.04 14.5 0.1 11 6.7 0.0 3.3 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region DUF383 PF04063.14 ORX68156.1 - 0.075 12.7 0.0 0.28 10.8 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF383) AMP-binding PF00501.28 ORX68157.1 - 2.8e-74 250.2 0.0 4.2e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX68157.1 - 3.4e-16 60.0 1.5 9.5e-16 58.5 1.5 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 ORX68157.1 - 0.001 18.1 0.0 0.0044 15.9 0.0 1.8 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 ORX68157.1 - 0.013 15.5 0.0 0.037 14.1 0.0 1.6 1 1 1 2 2 2 0 RTX C-terminal domain NDC10_II PF16787.5 ORX68159.1 - 4e-12 45.8 0.2 1.7e-05 24.0 0.1 2.3 2 0 0 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Ribosomal_L16 PF00252.18 ORX68160.1 - 9.7e-44 148.6 0.1 1.7e-43 147.8 0.1 1.3 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e Ecl1 PF12855.7 ORX68162.1 - 1.9e-11 45.4 7.4 2.3e-11 45.2 7.4 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2116 PF09889.9 ORX68162.1 - 0.011 15.6 0.9 0.017 15.1 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MRVI1 PF05781.12 ORX68162.1 - 0.2 10.3 0.2 0.21 10.3 0.2 1.0 1 0 0 1 1 1 0 MRVI1 protein CCDC84 PF14968.6 ORX68162.1 - 0.27 10.8 1.3 0.37 10.4 1.3 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 CopK PF11525.8 ORX68164.1 - 0.0094 15.6 0.1 8.4 6.1 0.0 3.0 3 0 0 3 3 3 2 Copper resistance protein K YoaP PF14268.6 ORX68164.1 - 0.051 13.1 1.0 5.1 6.7 0.1 2.5 2 0 0 2 2 2 0 YoaP-like Endomucin PF07010.12 ORX68164.1 - 0.079 12.9 6.5 0.16 11.9 6.5 1.5 1 0 0 1 1 1 0 Endomucin Trypan_PARP PF05887.11 ORX68164.1 - 0.19 11.7 9.5 0.076 13.0 6.0 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF1180 PF06679.12 ORX68164.1 - 0.99 9.8 7.4 2.7 8.4 7.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) CRM1_repeat PF18777.1 ORX68164.1 - 1.4 8.5 3.4 3.1 7.4 0.3 2.6 3 0 0 3 3 3 0 Chromosome region maintenance or exportin repeat CBM_14 PF01607.24 ORX68164.1 - 5.3 7.3 90.7 0.16 12.2 4.9 8.6 5 1 3 8 8 8 0 Chitin binding Peritrophin-A domain Ecl1 PF12855.7 ORX68166.1 - 1.9e-11 45.4 7.4 2.3e-11 45.2 7.4 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2116 PF09889.9 ORX68166.1 - 0.011 15.6 0.9 0.017 15.1 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MRVI1 PF05781.12 ORX68166.1 - 0.2 10.3 0.2 0.21 10.3 0.2 1.0 1 0 0 1 1 1 0 MRVI1 protein CCDC84 PF14968.6 ORX68166.1 - 0.27 10.8 1.3 0.37 10.4 1.3 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 MFS_1 PF07690.16 ORX68168.1 - 6.3e-27 94.4 55.9 9.5e-18 64.2 19.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX68168.1 - 1.4e-05 24.2 35.5 0.00075 18.5 5.0 3.1 3 0 0 3 3 3 3 Sugar (and other) transporter Aldo_ket_red PF00248.21 ORX68169.1 - 4e-24 85.3 0.0 5.1e-22 78.4 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1729 PF08354.10 ORX68170.1 - 3.9e-90 302.3 8.7 1.2e-59 202.0 0.0 3.6 2 1 2 4 4 4 3 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 ORX68170.1 - 3.5e-38 131.3 0.0 8.4e-38 130.0 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 ORX68170.1 - 2.5e-31 109.2 0.1 9.4e-26 91.1 0.1 2.5 1 1 1 2 2 2 2 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 ORX68170.1 - 1.1e-26 94.0 2.6 6.7e-26 91.4 0.8 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ORX68170.1 - 3.2e-26 91.3 0.1 1.5e-25 89.2 0.0 2.1 2 0 0 2 2 2 1 MaoC like domain Acyl_transf_1 PF00698.21 ORX68170.1 - 1.7e-23 83.7 0.0 8e-15 55.1 0.0 3.8 4 1 1 5 5 5 2 Acyl transferase domain Ketoacyl-synt_C PF02801.22 ORX68170.1 - 3.6e-12 46.3 0.0 1.1e-11 44.7 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX68170.1 - 4.2e-10 39.9 0.0 1.2e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase SAT PF16073.5 ORX68170.1 - 7.5e-06 25.8 0.1 4.3e-05 23.4 0.0 2.3 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 ORX68170.1 - 8.2e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain 2-Hacid_dh_C PF02826.19 ORX68170.1 - 0.13 11.6 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thiolase_N PF00108.23 ORX68170.1 - 0.18 11.1 0.6 0.44 9.9 0.1 1.8 2 0 0 2 2 2 0 Thiolase, N-terminal domain PMT PF02366.18 ORX68171.1 - 3.5e-50 170.9 13.5 3.5e-50 170.9 13.5 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX68171.1 - 1.9e-12 47.2 12.2 1.9e-12 47.2 12.2 4.0 3 1 1 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX68171.1 - 0.0028 17.5 0.3 0.0051 16.7 0.1 1.4 1 1 0 1 1 1 1 MIR domain DUF1325 PF07039.11 ORX68172.1 - 2.1e-26 92.5 0.0 3.5e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 ORX68172.1 - 0.0009 19.0 0.3 1.6 8.7 0.0 2.9 3 0 0 3 3 3 2 DNA repair protein Crb2 Tudor domain SWIRM-assoc_2 PF16496.5 ORX68172.1 - 0.26 10.1 2.9 0.39 9.5 2.9 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Myb_DNA-binding PF00249.31 ORX68173.1 - 4.9e-07 29.8 20.6 0.066 13.4 0.2 6.5 5 2 2 7 7 7 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX68173.1 - 0.00059 20.0 9.0 0.015 15.5 1.9 4.0 2 2 1 3 3 3 1 Myb-like DNA-binding domain HTH_32 PF13565.6 ORX68173.1 - 0.0032 18.1 2.9 0.18 12.4 0.1 3.4 1 1 2 3 3 3 1 Homeodomain-like domain Rif1_N PF12231.8 ORX68173.1 - 0.13 11.2 0.1 1.4 7.8 0.1 2.1 2 0 0 2 2 2 0 Rap1-interacting factor 1 N terminal BPL_N PF09825.9 ORX68174.1 - 1.2e-70 238.5 0.0 1.9e-70 237.8 0.0 1.3 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 ORX68174.1 - 1.8e-17 63.5 0.0 3.5e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 ORX68174.1 - 0.00063 19.6 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain DUF3684 PF12449.8 ORX68175.1 - 1.4e-85 288.1 0.0 1.7e-85 287.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) DUF3684 PF12449.8 ORX68176.1 - 2.5e-07 29.0 0.1 2.9e-07 28.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) DUF3684 PF12449.8 ORX68177.1 - 1.3e-40 139.2 0.2 1.6e-40 138.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 ORX68178.1 - 0.018 14.8 0.2 0.033 14.0 0.2 1.6 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CLPTM1 PF05602.12 ORX68179.1 - 2.2e-41 142.3 0.3 2.6e-41 142.1 0.3 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ORX68179.1 - 0.0017 18.1 2.3 0.0066 16.2 0.1 2.6 3 0 0 3 3 3 1 PQ loop repeat B12D PF06522.11 ORX68179.1 - 0.0033 17.2 1.1 0.026 14.3 0.0 2.9 3 1 1 4 4 4 1 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF4191 PF13829.6 ORX68179.1 - 2.1 7.7 5.1 2.5 7.4 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) Glyco_hydro_46 PF01374.18 ORX68180.1 - 1e-28 100.4 8.8 1.1e-17 64.4 0.8 2.9 2 1 0 2 2 2 2 Glycosyl hydrolase family 46 Cdc6_C PF09079.11 ORX68182.1 - 6.4e-10 38.9 0.0 2.1e-09 37.3 0.0 1.8 1 1 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 ORX68182.1 - 1e-07 32.5 0.2 1e-06 29.3 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 ORX68182.1 - 1.4e-06 28.8 0.0 4.6e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX68182.1 - 4.2e-05 23.8 0.5 0.003 17.8 0.1 2.6 1 1 1 2 2 2 1 AAA domain PIF1 PF05970.14 ORX68182.1 - 0.0026 17.0 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_7 PF12775.7 ORX68182.1 - 0.0053 16.3 0.0 0.0097 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RFX_DNA_binding PF02257.15 ORX68182.1 - 0.015 15.9 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 RFX DNA-binding domain AAA_lid_10 PF17872.1 ORX68182.1 - 0.019 15.1 0.1 0.047 13.8 0.1 1.6 1 0 0 1 1 1 0 AAA lid domain AAA_19 PF13245.6 ORX68182.1 - 0.02 15.3 0.0 0.061 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 ORX68182.1 - 0.025 14.2 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Viral_helicase1 PF01443.18 ORX68182.1 - 0.053 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 ORX68182.1 - 0.067 13.1 0.1 0.28 11.1 0.1 2.0 1 1 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 ORX68182.1 - 0.077 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TniB PF05621.11 ORX68182.1 - 0.12 11.7 0.8 25 4.2 0.0 3.0 2 1 1 3 3 3 0 Bacterial TniB protein DNA_binding_1 PF01035.20 ORX68183.1 - 2.9e-23 81.8 0.0 4.5e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain HUN PF08729.10 ORX68184.1 - 4.5e-05 23.4 4.7 4.5e-05 23.4 4.7 2.8 2 1 0 2 2 2 1 HPC2 and ubinuclein domain DUF3381 PF11861.8 ORX68184.1 - 8.5 6.2 12.2 5.3 6.8 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3381) UBN_AB PF14075.6 ORX68185.1 - 2.1e-08 34.2 0.5 0.01 15.6 0.4 3.1 2 1 0 2 2 2 2 Ubinuclein conserved middle domain Ribosomal_S18 PF01084.20 ORX68186.1 - 7.4e-22 77.3 0.1 1.5e-21 76.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 Arf PF00025.21 ORX68187.1 - 3.6e-78 261.0 0.0 4.1e-78 260.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX68187.1 - 2.6e-15 56.7 0.0 3.5e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX68187.1 - 1.9e-13 50.3 0.0 2.2e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ORX68187.1 - 2.9e-12 46.5 1.3 9.1e-08 31.6 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX68187.1 - 3.4e-12 46.2 0.0 4.2e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX68187.1 - 1.2e-09 37.9 0.0 1.5e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX68187.1 - 0.00026 21.1 0.0 0.00037 20.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ORX68187.1 - 0.0018 17.6 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase URO-D PF01208.17 ORX68188.1 - 4.5e-95 318.7 0.0 2.1e-94 316.5 0.0 1.8 1 1 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) zf-Tim10_DDP PF02953.15 ORX68189.1 - 1.1e-17 63.4 5.9 1.5e-17 62.9 5.9 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Prenylcys_lyase PF07156.14 ORX68189.1 - 0.018 14.2 0.4 0.021 14.0 0.4 1.0 1 0 0 1 1 1 0 Prenylcysteine lyase Peptidase_S10 PF00450.22 ORX68190.1 - 9.2e-55 186.7 1.5 1.2e-54 186.4 1.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase tRNA-synt_2c PF01411.19 ORX68191.1 - 3.4e-129 431.9 0.0 3.8e-64 217.2 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ORX68191.1 - 4.6e-08 33.0 0.3 1.4e-07 31.4 0.1 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ORX68191.1 - 0.078 13.4 5.5 0.06 13.8 2.9 2.2 2 1 0 2 2 2 0 DHHA1 domain MMR_HSR1 PF01926.23 ORX68192.1 - 3.6e-16 59.3 0.1 1.1e-14 54.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX68192.1 - 7.9e-11 41.7 0.1 9.1e-07 28.5 0.1 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX68192.1 - 7e-08 32.6 0.1 0.0005 20.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 ORX68192.1 - 0.0017 17.7 0.6 0.024 14.0 0.0 2.2 2 0 0 2 2 2 1 AIG1 family DUF4193 PF13834.6 ORX68192.1 - 0.11 13.0 4.0 8.7 6.9 1.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) Dynamin_N PF00350.23 ORX68192.1 - 1.5 8.9 6.9 0.27 11.3 0.4 2.9 3 1 1 4 4 4 0 Dynamin family Myb_DNA-bind_4 PF13837.6 ORX68193.1 - 6.7e-06 26.4 3.5 1.1e-05 25.7 0.0 2.9 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain DUF16 PF01519.16 ORX68193.1 - 0.014 15.9 5.5 0.014 15.9 5.5 3.7 2 1 1 4 4 4 0 Protein of unknown function DUF16 XhlA PF10779.9 ORX68193.1 - 1.7 8.9 8.1 3.4 8.0 3.0 2.7 1 1 1 2 2 2 0 Haemolysin XhlA ABC_tran PF00005.27 ORX68194.1 - 3.5e-26 92.3 0.0 5.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68194.1 - 3e-05 23.6 0.0 0.00034 20.1 0.0 1.9 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 ORX68194.1 - 0.011 15.4 0.2 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX68194.1 - 0.024 14.4 0.2 0.13 12.0 0.2 2.1 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ORX68194.1 - 0.046 13.0 0.4 3.9 6.7 0.1 2.2 2 0 0 2 2 2 0 Zeta toxin ResIII PF04851.15 ORX68194.1 - 0.069 13.1 0.0 0.16 12.0 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_24 PF13479.6 ORX68194.1 - 0.21 11.3 0.0 0.55 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 ORX68194.1 - 0.32 10.8 1.0 13 5.5 0.1 2.4 2 1 0 2 2 2 0 DEAD/DEAH box helicase ABC_tran PF00005.27 ORX68196.1 - 4.2e-05 24.1 0.1 7.5e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ORX68196.1 - 0.0053 16.5 0.2 0.013 15.3 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX68196.1 - 0.017 15.5 0.3 0.071 13.5 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain MYO10_CC PF16735.5 ORX68196.1 - 0.062 13.4 0.6 0.14 12.3 0.6 1.6 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain Dynamin_N PF00350.23 ORX68196.1 - 0.07 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Dynamin family T2SSE PF00437.20 ORX68196.1 - 0.077 12.0 0.0 0.24 10.4 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 ORX68196.1 - 0.093 12.0 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 ORX68196.1 - 0.15 12.0 0.2 0.34 10.8 0.2 1.8 1 1 0 1 1 1 0 RsgA GTPase cobW PF02492.19 ORX68196.1 - 0.15 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 ORX68196.1 - 0.16 11.2 0.1 0.25 10.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Actin PF00022.19 ORX68198.1 - 8.7e-50 169.5 0.0 7.7e-30 103.8 0.0 2.4 2 1 0 2 2 2 2 Actin DNA_methylase PF00145.17 ORX68199.1 - 1.6e-08 34.3 0.0 6e-07 29.1 0.0 2.2 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.8 ORX68200.1 - 2.5e-14 53.5 0.0 6.3e-14 52.2 0.0 1.6 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain PBP1_TM PF14812.6 ORX68200.1 - 6.8 7.1 7.5 0.23 11.9 0.5 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Asp PF00026.23 ORX68201.1 - 5.8e-65 219.8 0.1 4.1e-53 180.8 0.2 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX68201.1 - 3.8e-10 40.3 0.4 3.4e-05 24.2 0.0 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX68201.1 - 7.9e-05 22.5 0.0 0.0064 16.3 0.0 2.6 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX68201.1 - 0.016 15.7 0.1 14 6.4 0.1 3.0 2 1 1 3 3 3 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ORX68201.1 - 0.077 13.6 0.7 23 5.7 0.0 2.9 2 1 0 2 2 2 0 Aspartyl protease LRR_4 PF12799.7 ORX68202.1 - 7.5e-27 92.9 29.5 1.7e-06 28.3 7.6 6.0 3 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX68202.1 - 5.7e-22 77.2 25.3 1.8e-07 30.8 4.2 5.3 2 1 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 ORX68202.1 - 7e-18 64.7 11.4 9.2e-11 41.5 0.2 2.9 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 ORX68202.1 - 0.00029 21.0 22.0 5.4 8.0 0.8 7.5 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 ORX68202.1 - 0.00096 19.0 32.8 0.6 10.3 0.8 8.5 8 0 0 8 8 8 3 Leucine Rich repeat MitoNEET_N PF10660.9 ORX68204.1 - 0.48 10.5 2.2 10 6.3 0.1 2.3 2 1 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Arrestin_N PF00339.29 ORX68205.1 - 0.017 15.2 0.0 0.11 12.6 0.0 2.2 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Ribonuc_L-PSP PF01042.21 ORX68206.1 - 8.2e-43 145.3 0.2 9.1e-43 145.1 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP RNA_pol_3_Rpc31 PF11705.8 ORX68207.1 - 1.3e-13 51.8 20.5 1.4e-10 41.8 0.3 2.2 1 1 1 2 2 2 2 DNA-directed RNA polymerase III subunit Rpc31 DUF747 PF05346.11 ORX68208.1 - 0.0095 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF747 PF05346.11 ORX68209.1 - 7.1e-33 114.4 7.0 7.7e-28 97.9 1.5 2.1 1 1 1 2 2 2 2 Eukaryotic membrane protein family NUDE_C PF04880.13 ORX68209.1 - 0.046 14.2 0.6 0.046 14.2 0.6 3.0 2 1 2 4 4 4 0 NUDE protein, C-terminal conserved region 2OG-FeII_Oxy_2 PF13532.6 ORX68210.1 - 2.4e-33 116.0 0.0 5.7e-33 114.8 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Hydrolase PF00702.26 ORX68212.1 - 4.1e-15 56.7 0.0 7e-11 42.8 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX68212.1 - 8.7e-14 52.0 0.0 3.6e-11 43.5 0.0 2.7 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX68212.1 - 1.2e-06 29.1 0.1 0.00065 20.1 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX68212.1 - 1.6e-06 28.0 0.0 2.7e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ORX68212.1 - 1.3e-05 25.2 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX68212.1 - 0.057 13.1 0.0 4.2 7.0 0.0 2.7 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ORX68212.1 - 0.082 12.5 0.0 3.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Rap1_C PF11626.8 ORX68214.1 - 4.1e-05 23.6 0.0 8.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain NTP_transferase PF00483.23 ORX68215.1 - 7e-30 104.4 0.0 9.4e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ORX68215.1 - 9e-07 28.4 10.0 4.3e-05 23.1 0.2 3.5 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX68215.1 - 0.00085 19.7 0.0 0.0019 18.6 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 ORX68215.1 - 0.0012 17.1 0.0 0.002 16.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 ORX68215.1 - 0.084 12.6 0.4 0.084 12.6 0.4 2.7 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase AMP-binding PF00501.28 ORX68218.1 - 6.5e-93 311.6 0.0 8.1e-93 311.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX68218.1 - 1.7e-09 38.5 0.2 4.7e-09 37.1 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain U62_UL91 PF17442.2 ORX68219.1 - 0.004 17.1 0.0 0.0066 16.4 0.0 1.3 1 0 0 1 1 1 1 Functional domain of U62 and UL91 proteins Helo_like_N PF17111.5 ORX68219.1 - 0.081 12.3 0.0 0.23 10.8 0.0 1.6 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins ERG4_ERG24 PF01222.17 ORX68220.1 - 1.2e-131 439.5 16.7 1.3e-131 439.3 16.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family F_actin_cap_B PF01115.17 ORX68221.1 - 2.3e-104 348.3 0.0 2.6e-104 348.0 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Noelin-1 PF12308.8 ORX68221.1 - 0.13 12.3 0.6 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 Neurogenesis glycoprotein EcsB PF05975.12 ORX68222.1 - 1.6 7.5 8.1 0.22 10.3 2.7 1.9 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB Bromodomain PF00439.25 ORX68225.1 - 2e-19 69.4 0.1 2.1e-19 69.3 0.1 1.0 1 0 0 1 1 1 1 Bromodomain Ribosomal_L5_C PF00673.21 ORX68226.1 - 1.7e-23 82.6 0.0 3.2e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ORX68226.1 - 4.2e-14 52.6 0.0 9.3e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L5 Carn_acyltransf PF00755.20 ORX68228.1 - 4.7e-138 461.4 0.0 5.4e-138 461.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase FBP_C PF16571.5 ORX68228.1 - 0.13 11.8 0.3 0.24 10.9 0.3 1.4 1 0 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger HalX PF08663.10 ORX68228.1 - 2.6 8.4 5.3 2.8 8.3 1.5 2.5 2 0 0 2 2 2 0 HalX domain Carn_acyltransf PF00755.20 ORX68229.1 - 5.8e-191 636.1 0.0 6.5e-191 635.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Tyrosinase PF00264.20 ORX68231.1 - 6.1e-31 108.4 2.6 8.3e-30 104.7 2.6 2.4 1 1 0 1 1 1 1 Common central domain of tyrosinase Kunitz_BPTI PF00014.23 ORX68231.1 - 0.19 12.0 1.9 3.1 8.1 0.1 3.1 3 0 0 3 3 3 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Tyrosinase PF00264.20 ORX68232.1 - 1.9e-12 48.0 0.4 3.7e-12 47.0 0.4 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyrosinase PF00264.20 ORX68234.1 - 2e-21 77.3 1.8 2.6e-19 70.4 1.1 3.0 2 1 0 2 2 2 1 Common central domain of tyrosinase DEAD PF00270.29 ORX68235.1 - 6.9e-46 156.2 0.2 2.6e-45 154.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX68235.1 - 5.4e-25 87.9 0.1 6.7e-24 84.4 0.0 2.5 2 1 2 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX68235.1 - 2.9e-17 62.6 0.1 5.3e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX68235.1 - 7e-05 22.9 0.0 0.00017 21.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NUC173 PF08161.12 ORX68236.1 - 1.1e-62 211.3 1.9 1.4e-59 201.2 0.0 3.7 3 0 0 3 3 3 2 NUC173 domain MMS19_C PF12460.8 ORX68236.1 - 4.2e-06 26.1 12.8 9.1e-05 21.7 0.9 3.8 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal ssDNA_DBD PF18333.1 ORX68236.1 - 0.24 11.5 2.9 1 9.5 0.7 2.6 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain DUF4404 PF14357.6 ORX68236.1 - 0.53 11.0 2.8 42 4.9 1.5 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) CLASP_N PF12348.8 ORX68236.1 - 0.92 9.0 3.5 9.8 5.7 0.0 3.4 4 1 0 4 4 4 0 CLASP N terminal HEAT PF02985.22 ORX68236.1 - 4.4 7.8 7.1 12 6.5 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat Forkhead PF00250.18 ORX68237.1 - 2.4e-28 98.2 1.0 6e-14 52.1 0.3 2.3 2 0 0 2 2 2 2 Forkhead domain Nup88 PF10168.9 ORX68238.1 - 1.2e-06 26.7 0.0 3.8e-06 25.1 0.0 1.7 1 1 0 1 1 1 1 Nuclear pore component Lipase_GDSL_2 PF13472.6 ORX68243.1 - 1.1e-06 29.2 0.1 1.5e-06 28.8 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX68243.1 - 1.4e-06 28.4 0.0 1.7e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Ribosomal_L26 PF16906.5 ORX68244.1 - 2.9e-34 117.4 2.3 3.8e-34 117.0 2.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ORX68244.1 - 6.1e-09 35.5 1.2 1.1e-08 34.7 1.2 1.4 1 0 0 1 1 1 1 KOW motif Rib_5-P_isom_A PF06026.14 ORX68244.1 - 0.054 13.1 0.8 0.085 12.4 0.5 1.4 1 1 1 2 2 2 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) tRNA-synt_2 PF00152.20 ORX68245.1 - 2.9e-71 240.1 0.1 5.4e-71 239.2 0.1 1.5 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX68245.1 - 1.6e-12 47.3 0.0 3e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX68245.1 - 4.9e-09 36.0 0.1 0.00016 21.3 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) PT-TG PF14449.6 ORX68245.1 - 0.16 11.8 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Pre-toxin TG Glyco_hydro_72 PF03198.14 ORX68246.1 - 7.1e-120 400.0 3.0 9.8e-120 399.5 3.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ORX68246.1 - 3.7e-21 75.6 6.2 1.7e-20 73.5 6.2 2.3 1 1 0 1 1 1 1 X8 domain Cellulase PF00150.18 ORX68246.1 - 0.00011 21.7 0.4 0.00072 19.1 0.4 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 ORX68246.1 - 0.0054 15.9 1.6 0.055 12.6 1.6 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glucan_synthase PF02364.15 ORX68247.1 - 0 1210.5 0.0 0 1209.9 0.0 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ORX68247.1 - 2.1e-34 118.6 0.0 8.3e-34 116.7 0.0 2.1 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SQS_PSY PF00494.19 ORX68249.1 - 3.7e-44 151.2 0.0 4.5e-44 150.9 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Pribosyltran PF00156.27 ORX68250.1 - 1.4e-10 40.9 0.2 8.9e-10 38.3 0.2 1.9 1 1 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ORX68250.1 - 0.032 13.7 0.1 0.069 12.6 0.0 1.5 2 0 0 2 2 2 0 Phosphoribosyl transferase Pkinase PF00069.25 ORX68251.1 - 1e-67 228.3 0.0 1.8e-67 227.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX68251.1 - 7.2e-32 110.7 0.0 1.3e-31 109.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX68251.1 - 6.3e-05 22.4 0.0 0.00012 21.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Androgen_recep PF02166.16 ORX68251.1 - 0.00016 20.7 8.9 0.00021 20.3 8.9 1.1 1 0 0 1 1 1 1 Androgen receptor TFIIA PF03153.13 ORX68251.1 - 0.087 12.8 7.4 0.11 12.5 7.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 ORX68251.1 - 0.44 9.2 11.5 0.52 8.9 11.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal SUIM_assoc PF16619.5 ORX68251.1 - 0.97 9.5 12.5 1.9 8.6 12.5 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 ORX68251.1 - 2.1 7.9 10.2 3.1 7.3 10.2 1.2 1 0 0 1 1 1 0 Spt20 family Mito_carr PF00153.27 ORX68252.1 - 8.2e-57 189.1 12.7 4.4e-19 68.2 0.1 3.8 3 1 1 4 4 4 3 Mitochondrial carrier protein Peptidase_S8 PF00082.22 ORX68253.1 - 2.9e-36 125.3 9.6 6.5e-36 124.1 9.6 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ORX68253.1 - 1.3e-15 57.9 0.3 2.2e-15 57.1 0.3 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 GW PF13457.6 ORX68256.1 - 0.61 10.7 3.4 5.7 7.6 0.1 2.8 2 1 1 3 3 3 0 GW (Gly-Tryp) dipeptide domain Cu-oxidase PF00394.22 ORX68257.1 - 0.12 12.5 0.1 0.41 10.8 0.1 1.8 1 1 1 2 2 2 0 Multicopper oxidase ubiquitin PF00240.23 ORX68258.1 - 3e-103 337.7 15.2 5.5e-34 115.7 0.9 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ORX68258.1 - 2.9e-48 161.6 16.0 1.1e-15 57.2 1.0 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX68258.1 - 8.8e-19 67.8 7.2 9.9e-05 22.7 0.2 4.6 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ORX68258.1 - 1.6e-12 47.2 3.5 0.011 15.7 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ORX68258.1 - 4.7e-12 46.1 4.2 0.012 15.9 0.2 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX68258.1 - 4.8e-12 46.0 1.9 0.033 14.3 0.0 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX68258.1 - 1.7e-11 44.6 0.7 0.052 14.1 0.0 3.1 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 ORX68258.1 - 3.7e-08 33.4 0.2 0.44 10.4 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 ORX68258.1 - 1.3e-06 28.3 17.3 7 6.8 0.2 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain DUF3861 PF12977.7 ORX68258.1 - 2.1e-05 24.6 1.7 4.3 7.6 0.1 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 ORX68258.1 - 0.0003 21.1 0.0 20 5.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) DUF493 PF04359.14 ORX68258.1 - 0.001 19.6 0.1 30 5.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF493) ACT_5 PF13710.6 ORX68258.1 - 0.001 18.9 3.2 10 6.1 0.1 3.3 3 0 0 3 3 3 0 ACT domain DUF1940 PF09155.10 ORX68258.1 - 0.001 19.2 2.8 12 6.0 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1940) Methyltrans_RNA PF04452.14 ORX68258.1 - 0.0013 18.1 0.2 1.6 8.0 0.0 2.3 2 0 0 2 2 2 2 RNA methyltransferase Big_3_3 PF13750.6 ORX68258.1 - 0.0017 18.0 0.0 20 4.8 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Big_7 PF17957.1 ORX68258.1 - 0.0021 18.8 0.1 41 5.0 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig domain Raf1_HTH PF18579.1 ORX68258.1 - 0.0022 17.7 0.5 26 4.6 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain TmoB PF06234.12 ORX68258.1 - 0.0043 17.1 3.1 22 5.2 0.1 3.8 3 3 0 3 3 3 0 Toluene-4-monooxygenase system protein B (TmoB) DUF969 PF06149.12 ORX68258.1 - 0.0079 15.6 0.0 15 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 ORX68258.1 - 0.0087 16.6 0.6 58 4.4 0.0 3.3 3 0 0 3 3 3 0 ACT domain UDP-g_GGTase PF06427.11 ORX68258.1 - 0.012 15.8 3.8 4.3 7.5 0.1 3.2 4 0 0 4 4 3 0 UDP-glucose:Glycoprotein Glucosyltransferase ProRS-C_2 PF09181.10 ORX68258.1 - 0.046 13.9 2.9 48 4.2 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal ORF11CD3 PF10549.9 ORX68258.1 - 0.093 12.9 1.2 62 3.8 0.0 4.0 6 0 0 6 6 3 0 ORF11CD3 domain PI3K_p85B PF02192.16 ORX68258.1 - 0.1 12.3 6.1 24 4.7 0.1 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Baculo_p48 PF04878.13 ORX68258.1 - 0.11 11.4 0.1 14 4.4 0.0 2.4 3 0 0 3 3 3 0 Baculovirus P48 protein Tash_PEST PF07708.11 ORX68258.1 - 0.13 12.4 18.4 4.5 7.6 1.4 3.3 3 0 0 3 3 3 0 Tash protein PEST motif DMA PF03474.14 ORX68258.1 - 0.27 10.9 1.5 72 3.1 0.0 3.2 3 0 0 3 3 3 0 DMRTA motif Myosin_N PF02736.19 ORX68258.1 - 0.36 10.7 3.4 76 3.3 0.0 4.0 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain Plexin_cytopl PF08337.12 ORX68258.1 - 1.1 7.8 13.9 7.1 5.2 0.7 4.0 3 2 0 4 4 4 0 Plexin cytoplasmic RasGAP domain Phage_sheath_1N PF17481.2 ORX68258.1 - 1.7 9.1 5.6 47 4.5 1.6 3.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain Cnl2_NKP2 PF09447.10 ORX68258.1 - 8.7 6.6 7.8 1e+02 3.1 0.2 3.4 3 0 0 3 3 3 0 Cnl2/NKP2 family protein bZIP_2 PF07716.15 ORX68259.1 - 2e-08 34.2 15.9 2e-08 34.2 15.9 2.2 2 1 1 3 3 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX68259.1 - 5.2e-05 23.3 22.0 8.3e-05 22.6 15.3 2.3 1 1 1 2 2 2 2 bZIP transcription factor Nup54 PF13874.6 ORX68259.1 - 0.0043 17.1 4.2 0.0082 16.3 4.2 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 ATG16 PF08614.11 ORX68259.1 - 0.0075 16.5 8.2 0.0075 16.5 8.2 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) bZIP_Maf PF03131.17 ORX68259.1 - 0.0086 16.6 13.6 0.025 15.1 13.6 1.8 1 1 0 1 1 1 1 bZIP Maf transcription factor KASH_CCD PF14662.6 ORX68259.1 - 0.016 15.0 8.1 0.025 14.4 8.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Nsp1_C PF05064.13 ORX68259.1 - 0.12 12.2 4.2 0.23 11.3 4.2 1.3 1 0 0 1 1 1 0 Nsp1-like C-terminal region Atg14 PF10186.9 ORX68259.1 - 0.24 10.5 4.9 0.41 9.7 4.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cnn_1N PF07989.11 ORX68259.1 - 0.29 11.3 7.0 0.8 9.9 7.0 1.7 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 ORX68259.1 - 0.54 10.1 8.6 0.34 10.7 6.1 1.9 1 1 1 2 2 2 0 Septum formation initiator YabA PF06156.13 ORX68259.1 - 0.67 10.6 6.0 1.2 9.8 6.0 1.3 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 ORX68259.1 - 0.9 10.0 10.8 1.8 9.0 10.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Ribosomal_60s PF00428.19 ORX68259.1 - 1.2 9.7 4.8 4 8.1 4.8 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein ABC_tran_CTD PF16326.5 ORX68259.1 - 1.5 9.1 9.9 2.7 8.3 9.9 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain HAUS6_N PF14661.6 ORX68259.1 - 1.7 8.2 6.3 2.6 7.6 6.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus APG6_N PF17675.1 ORX68259.1 - 1.7 9.2 14.2 2.7 8.5 14.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Herpes_UL25 PF01499.16 ORX68259.1 - 1.9 6.9 6.0 2.8 6.3 3.8 2.0 2 0 0 2 2 2 0 Herpesvirus UL25 family Jnk-SapK_ap_N PF09744.9 ORX68259.1 - 2 8.6 10.8 3.3 7.9 10.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 ORX68259.1 - 3 7.9 14.7 5.3 7.1 14.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding vATP-synt_E PF01991.18 ORX68259.1 - 3.5 7.0 8.6 5.4 6.4 8.6 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF3450 PF11932.8 ORX68259.1 - 4.9 6.4 10.6 10 5.3 10.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Cep57_CLD_2 PF14197.6 ORX68259.1 - 8 6.6 18.4 3.1 8.0 12.2 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 CENP-H PF05837.12 ORX68259.1 - 9.1 6.7 11.9 39 4.7 11.9 2.0 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Elongin_A PF06881.11 ORX68261.1 - 2.3e-21 76.3 0.1 4.3e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A PMM PF03332.13 ORX68262.1 - 3.8e-105 350.5 0.6 4.2e-105 350.4 0.6 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Glyco_hydro_75 PF07335.11 ORX68262.1 - 0.058 13.7 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 Sirohm_synth_M PF14824.6 ORX68263.1 - 0.0082 15.6 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central E1-E2_ATPase PF00122.20 ORX68264.1 - 1.4e-21 76.8 0.0 3.4e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX68264.1 - 5e-19 69.4 0.0 8.8e-12 45.8 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX68264.1 - 0.0005 19.9 0.0 0.016 15.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ORX68264.1 - 0.015 14.8 0.5 0.035 13.7 0.1 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Cation_ATPase PF13246.6 ORX68264.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Borrelia_P83 PF05262.11 ORX68264.1 - 0.57 8.6 3.3 0.87 8.0 3.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein PHD PF00628.29 ORX68265.1 - 3e-08 33.4 12.5 8.6e-08 32.0 12.5 1.8 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX68265.1 - 0.0029 17.1 5.9 0.0029 17.1 5.9 2.5 3 0 0 3 3 3 1 PHD-finger PHF5 PF03660.14 ORX68265.1 - 0.0076 16.4 4.6 0.021 15.0 4.6 1.7 1 0 0 1 1 1 1 PHF5-like protein C1_1 PF00130.22 ORX68265.1 - 0.78 9.7 11.2 0.53 10.2 5.7 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) F-box-like PF12937.7 ORX68267.1 - 2.7e-10 39.9 0.2 7e-10 38.7 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 ORX68267.1 - 3.5e-08 32.8 11.4 0.87 9.8 0.1 8.5 9 0 0 9 9 9 4 Leucine Rich repeat F-box PF00646.33 ORX68267.1 - 2.5e-07 30.4 0.1 2.5e-07 30.4 0.1 2.5 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 ORX68267.1 - 6.6e-07 29.6 0.1 11 6.6 0.0 5.7 4 1 2 6 6 6 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX68267.1 - 0.16 11.8 1.4 39 4.1 0.0 4.6 6 1 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.33 ORX68267.1 - 1.4 9.7 7.4 66 4.7 0.0 5.8 7 1 0 7 7 7 0 Leucine Rich Repeat dCMP_cyt_deam_1 PF00383.23 ORX68268.1 - 4e-25 87.6 2.8 5.7e-25 87.1 2.8 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX68268.1 - 4.2e-14 52.5 0.1 6.8e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ORX68268.1 - 0.0023 18.0 0.1 0.0049 17.0 0.1 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 ORX68268.1 - 0.014 15.3 0.5 0.032 14.1 0.5 1.5 1 1 0 1 1 1 0 APOBEC-like N-terminal domain NAD1 PF18778.1 ORX68268.1 - 0.038 14.1 0.6 0.065 13.3 0.6 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 MBD PF01429.19 ORX68268.1 - 0.04 13.6 0.0 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 Methyl-CpG binding domain SWIRM PF04433.17 ORX68268.1 - 0.078 13.3 0.0 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 SWIRM domain APOBEC3 PF18771.1 ORX68268.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 APOBEC3 cobW PF02492.19 ORX68269.1 - 3.8e-34 117.8 0.0 4.6e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ORX68269.1 - 1.9e-05 23.8 0.4 0.0058 15.7 0.1 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_5 PF07728.14 ORX68269.1 - 0.0016 18.4 0.0 0.0025 17.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 ORX68269.1 - 0.006 16.6 0.0 0.019 15.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase CbiA PF01656.23 ORX68269.1 - 0.038 14.0 0.0 0.073 13.1 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 ORX68269.1 - 0.053 13.9 0.0 0.066 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 ORX68269.1 - 0.058 13.3 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ORX68269.1 - 0.068 13.1 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 ORX68269.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 ORX68269.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 ORX68269.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.6 1 1 0 1 1 1 0 NTPase TsaE PF02367.17 ORX68269.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 ORX68269.1 - 0.16 11.4 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 ORX68269.1 - 0.19 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region p450 PF00067.22 ORX68270.1 - 1e-81 275.1 0.0 1.4e-81 274.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 ORX68270.1 - 5e-29 101.4 0.0 8.8e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX68270.1 - 3.4e-21 75.9 0.0 1.4e-20 74.0 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX68270.1 - 2.1e-12 47.7 0.0 4.5e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ORX68270.1 - 0.019 15.2 0.0 0.054 13.7 0.0 1.8 1 0 0 1 1 1 0 Flavodoxin domain Herpes_US9 PF06072.11 ORX68271.1 - 0.02 14.7 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Mg_trans_NIPA PF05653.14 ORX68272.1 - 9.3e-12 44.6 9.3 2.8e-08 33.2 1.0 2.4 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ORX68272.1 - 0.93 9.7 21.7 0.05 13.8 3.2 2.7 2 1 0 2 2 2 0 EamA-like transporter family ACOX PF01756.19 ORX68273.1 - 2.1e-28 99.1 0.1 1.4e-27 96.4 0.1 2.2 1 1 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX68273.1 - 2.9e-15 56.9 0.0 5.7e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX68273.1 - 4.9e-09 36.3 0.1 2.1e-08 34.2 0.1 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ORX68273.1 - 2.5e-08 34.3 0.4 1.3e-06 28.7 0.7 3.1 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX68273.1 - 0.0032 17.8 1.4 0.006 16.9 0.2 2.2 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain ThiF PF00899.21 ORX68276.1 - 3.4e-62 210.0 0.0 4.2e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 ORX68276.1 - 4.6e-14 52.3 0.9 2e-13 50.3 0.9 2.0 1 1 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 ORX68276.1 - 0.0068 16.5 0.2 0.035 14.2 0.1 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Gmx_para_CXXCG PF09535.10 ORX68276.1 - 0.041 13.1 0.3 0.74 9.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) Sacchrp_dh_NADP PF03435.18 ORX68276.1 - 0.059 13.6 0.1 0.16 12.3 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ORX68276.1 - 0.095 13.0 0.2 0.44 10.8 0.0 2.2 2 1 0 2 2 2 0 TrkA-N domain Histone PF00125.24 ORX68277.1 - 4.4e-49 166.2 1.6 5e-49 166.0 1.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX68277.1 - 7.1e-05 22.9 0.1 0.00013 22.0 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ORX68277.1 - 0.00016 21.9 0.0 0.00025 21.4 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 ORX68277.1 - 0.00079 20.0 1.3 0.00098 19.7 1.3 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ORX68277.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 ORX68277.1 - 0.055 13.5 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 ORX68277.1 - 0.096 12.8 0.1 0.16 12.1 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Sas10_Utp3 PF04000.15 ORX68278.1 - 3.2e-13 50.1 0.0 4.5e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Bombinin PF05298.11 ORX68278.1 - 0.096 12.4 0.0 0.13 12.0 0.0 1.3 1 1 0 1 1 1 0 Bombinin FTHFS PF01268.19 ORX68279.1 - 7.1e-208 691.3 0.0 6.3e-206 684.9 0.0 2.1 1 1 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 ORX68279.1 - 2.1e-64 215.7 1.0 4.2e-64 214.7 0.4 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ORX68279.1 - 1.2e-38 131.9 0.7 3.9e-38 130.3 0.7 1.9 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 ORX68279.1 - 0.0043 16.0 0.2 0.0075 15.2 0.2 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family DUF1442 PF07279.11 ORX68279.1 - 0.21 10.9 0.8 0.57 9.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1442) ABC_tran PF00005.27 ORX68280.1 - 5.7e-41 140.2 0.0 2.9e-29 102.3 0.0 3.0 2 1 1 3 3 3 2 ABC transporter ABC_membrane PF00664.23 ORX68280.1 - 2.1e-36 126.0 13.9 1e-25 90.9 6.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX68280.1 - 1.1e-08 34.8 0.1 0.0002 20.8 0.0 3.2 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 ORX68280.1 - 0.0098 16.0 0.1 0.044 13.9 0.0 1.9 2 0 0 2 2 2 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 ORX68280.1 - 0.032 14.3 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX68280.1 - 0.086 13.2 0.1 0.37 11.1 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ORX68280.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain GCS PF03074.16 ORX68281.1 - 1.7e-153 511.4 0.0 2.1e-153 511.1 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF2019 PF09450.10 ORX68281.1 - 0.0096 15.9 0.2 0.025 14.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2019) MukF_C PF17193.4 ORX68281.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 MukF C-terminal domain SelP_N PF04592.14 ORX68282.1 - 0.2 11.0 18.9 0.4 10.1 18.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CDC27 PF09507.10 ORX68282.1 - 0.28 10.5 6.0 0.077 12.4 2.3 1.9 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 RSB_motif PF16294.5 ORX68282.1 - 2 8.7 6.3 10 6.5 6.3 2.2 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif UAA PF08449.11 ORX68283.1 - 3.3e-52 177.6 16.9 3.8e-52 177.4 16.9 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX68283.1 - 2.7e-08 34.1 17.4 9.4e-06 25.8 7.6 2.6 2 2 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 ORX68283.1 - 2.2e-06 27.4 13.6 3e-06 27.0 13.6 1.2 1 0 0 1 1 1 1 Solute carrier family 35 Nuc_sug_transp PF04142.15 ORX68283.1 - 6e-05 22.4 6.6 0.014 14.5 2.4 2.3 1 1 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 ORX68283.1 - 0.16 11.3 12.4 0.46 9.8 12.4 1.7 1 1 0 1 1 1 0 Triose-phosphate Transporter family CAP_N PF01213.19 ORX68284.1 - 1.6e-107 359.7 0.0 2.5e-107 359.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 ORX68284.1 - 9.3e-57 191.0 4.2 1.3e-56 190.6 4.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ORX68284.1 - 0.032 14.0 2.2 0.062 13.0 2.2 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor C Ribosomal_60s PF00428.19 ORX68284.1 - 0.82 10.3 14.6 2.2 8.9 0.4 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein Mito_fiss_reg PF05308.11 ORX68284.1 - 1 9.4 4.3 3.2 7.7 0.9 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator Adaptin_binding PF10199.9 ORX68285.1 - 8.5e-11 42.5 1.6 1.7e-10 41.5 1.6 1.5 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 UPF0014 PF03649.13 ORX68287.1 - 5.7e-66 222.3 21.0 6.4e-66 222.2 21.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Phage_holin_5_2 PF16079.5 ORX68287.1 - 0.0041 17.4 0.2 0.0041 17.4 0.2 3.2 1 1 2 3 3 3 1 Phage holin family Hol44, in holin superfamily V UPF0014 PF03649.13 ORX68288.1 - 1.2e-67 227.8 26.7 1.5e-67 227.5 26.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) DUF5453 PF17534.2 ORX68288.1 - 0.74 9.7 0.0 0.74 9.7 0.0 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5453) Ndc80_HEC PF03801.13 ORX68289.1 - 1.6e-27 96.0 0.0 4.1e-27 94.7 0.0 1.7 1 0 0 1 1 1 1 HEC/Ndc80p family Spc7 PF08317.11 ORX68289.1 - 0.002 17.1 12.1 0.002 17.1 12.1 2.9 1 1 2 3 3 3 2 Spc7 kinetochore protein PCNA_N PF00705.18 ORX68289.1 - 0.18 11.5 4.2 0.078 12.7 0.8 2.2 2 0 0 2 2 2 0 Proliferating cell nuclear antigen, N-terminal domain DUF3584 PF12128.8 ORX68289.1 - 2.4 5.6 38.8 2.2e+02 -0.9 38.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4266 PF14086.6 ORX68289.1 - 3 8.9 5.0 20 6.3 1.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4266) Sod_Fe_C PF02777.18 ORX68290.1 - 1.4e-27 95.9 0.2 1.4e-26 92.6 0.2 2.1 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ORX68290.1 - 3.6e-08 33.8 0.0 6.3e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SGT1 PF07093.11 ORX68291.1 - 2e-70 237.9 2.7 3.9e-67 227.0 0.1 2.6 2 1 1 3 3 3 2 SGT1 protein HSF_DNA-bind PF00447.17 ORX68294.1 - 3.4e-06 27.6 0.5 6.1e-06 26.8 0.5 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding DHQ_synthase PF01761.20 ORX68294.1 - 0.17 11.0 0.1 0.31 10.1 0.1 1.3 1 0 0 1 1 1 0 3-dehydroquinate synthase Lipase_3 PF01764.25 ORX68295.1 - 2.9e-29 101.8 0.0 4.3e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX68295.1 - 0.00029 20.4 0.0 0.13 11.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 ORX68296.1 - 8.8e-29 100.2 0.0 1.3e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX68296.1 - 0.00014 21.5 0.0 0.056 13.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 ORX68297.1 - 1.6e-37 128.5 0.0 1.9e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX68297.1 - 0.00014 21.5 0.0 0.085 12.4 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 ORX68297.1 - 0.049 12.9 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 YAcAr PF10686.9 ORX68297.1 - 0.088 12.8 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family DUF5039 PF16442.5 ORX68297.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) GTP_EFTU PF00009.27 ORX68298.1 - 1.6e-57 194.2 0.0 2.4e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ORX68298.1 - 6.6e-15 54.9 0.0 1.8e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX68298.1 - 4.4e-12 46.2 0.0 1.1e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ORX68298.1 - 1.2e-06 28.5 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 ORX68298.1 - 0.00018 21.3 0.0 0.00071 19.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV SGT1 PF07093.11 ORX68298.1 - 0.3 9.5 1.1 0.73 8.2 1.1 1.6 1 0 0 1 1 1 0 SGT1 protein FAM176 PF14851.6 ORX68298.1 - 0.49 10.0 3.6 3.7 7.2 0.5 2.8 2 0 0 2 2 2 0 FAM176 family DUF3246 PF11596.8 ORX68298.1 - 1.9 7.9 14.1 4.8 6.5 0.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) dCMP_cyt_deam_2 PF08211.12 ORX68299.1 - 1.9e-12 47.5 0.0 4.7e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MT-A70 PF05063.14 ORX68299.1 - 6.7e-10 39.1 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 MT-A70 dCMP_cyt_deam_1 PF00383.23 ORX68299.1 - 2.2e-09 37.1 0.1 6.7e-09 35.6 0.0 1.7 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region HNF-1_N PF04814.13 ORX68299.1 - 0.036 14.7 0.5 0.056 14.1 0.5 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Lipase_3 PF01764.25 ORX68300.1 - 6.8e-37 126.5 0.0 9.7e-37 126.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 ORX68300.1 - 0.032 13.9 0.0 0.078 12.7 0.0 1.6 1 1 1 2 2 2 0 PGAP1-like protein Hydrolase_4 PF12146.8 ORX68300.1 - 0.045 13.0 0.1 0.063 12.5 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 ORX68300.1 - 0.063 12.8 0.0 0.24 10.9 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX68300.1 - 0.11 13.1 5.4 0.16 12.6 5.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 ORX68301.1 - 1.8e-41 141.4 0.0 2.2e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX68301.1 - 0.00011 21.8 0.2 0.0012 18.5 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Cutinase PF01083.22 ORX68301.1 - 0.00047 20.1 0.0 0.00062 19.8 0.0 1.3 1 0 0 1 1 1 1 Cutinase Hydrolase_4 PF12146.8 ORX68301.1 - 0.00079 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX68301.1 - 0.0032 18.1 0.0 0.0037 17.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PE-PPE PF08237.11 ORX68301.1 - 0.0033 17.0 0.0 0.0047 16.5 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain DUF676 PF05057.14 ORX68301.1 - 0.016 14.7 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.12 ORX68301.1 - 0.019 14.4 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_5 PF12695.7 ORX68301.1 - 0.023 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX68301.1 - 0.044 13.4 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 ORX68301.1 - 0.05 13.3 0.1 0.093 12.4 0.0 1.4 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_8 PF06259.12 ORX68301.1 - 0.12 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase MGC-24 PF05283.11 ORX68303.1 - 0.23 11.9 8.7 0.97 9.9 8.7 2.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin zf-C3HC4 PF00097.25 ORX68303.1 - 0.58 10.1 5.1 1.6 8.6 5.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 ORX68303.1 - 0.68 10.4 3.4 1.3 9.5 3.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 ORX68303.1 - 1.2 9.1 7.3 2 8.3 7.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Toxin_TOLIP PF00087.21 ORX68303.1 - 7.7 6.8 8.3 13 6.1 8.3 1.4 1 0 0 1 1 1 0 Snake toxin and toxin-like protein Arrestin_N PF00339.29 ORX68304.1 - 2.7e-07 30.7 0.0 7e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX68304.1 - 2.1e-05 25.0 0.0 5.6e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Helicase_C PF00271.31 ORX68305.1 - 4.5e-20 72.1 0.0 1.5e-19 70.4 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX68305.1 - 1.2e-18 67.5 0.0 2.6e-18 66.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX68305.1 - 1.7e-18 67.2 0.0 3.1e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX68305.1 - 0.001 18.4 0.1 0.0021 17.3 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 ORX68305.1 - 0.038 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 ORX68305.1 - 0.059 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Pacifastin_I PF05375.13 ORX68306.1 - 3.2e-08 33.2 5.3 9.5e-08 31.6 5.3 1.8 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) VWC PF00093.18 ORX68306.1 - 0.003 17.8 3.3 0.003 17.8 3.3 2.5 2 1 0 2 2 2 1 von Willebrand factor type C domain HMGL-like PF00682.19 ORX68307.1 - 5.1e-51 173.8 0.0 6.5e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 HMGL-like Snf7 PF03357.21 ORX68308.1 - 1.7e-17 63.6 10.2 4.5e-17 62.2 10.2 1.6 1 1 0 1 1 1 1 Snf7 Osteoregulin PF07175.11 ORX68308.1 - 0.16 12.2 0.6 0.2 11.9 0.6 1.2 1 0 0 1 1 1 0 Osteoregulin SepF PF04472.12 ORX68308.1 - 0.29 11.4 0.8 6.4 7.1 0.1 2.3 1 1 1 2 2 2 0 Cell division protein SepF Bac_DnaA PF00308.18 ORX68311.1 - 0.0026 17.6 0.0 0.007 16.2 0.0 1.6 2 0 0 2 2 2 1 Bacterial dnaA protein IstB_IS21 PF01695.17 ORX68311.1 - 0.0072 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 ORX68311.1 - 0.021 14.8 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ORX68311.1 - 0.059 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AT_hook PF02178.19 ORX68312.1 - 6.7 6.9 8.6 0.79 9.8 1.8 2.6 2 0 0 2 2 2 0 AT hook motif Synaptobrevin PF00957.21 ORX68313.1 - 1.1e-34 118.1 3.9 1.3e-34 117.9 3.9 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 ORX68313.1 - 0.0054 16.8 0.0 0.006 16.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF5345 PF17280.2 ORX68313.1 - 0.0071 16.3 0.4 0.01 15.8 0.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5345) Phage_Mu_Gam PF07352.12 ORX68313.1 - 0.034 14.1 0.5 0.04 13.8 0.5 1.1 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein LRRC37AB_C PF14914.6 ORX68313.1 - 0.058 13.3 1.5 0.075 12.9 1.5 1.4 1 1 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Fzo_mitofusin PF04799.13 ORX68313.1 - 0.21 11.2 2.2 0.16 11.5 1.2 1.3 1 1 0 1 1 1 0 fzo-like conserved region DUF2116 PF09889.9 ORX68313.1 - 1.7 8.7 4.3 3 7.9 4.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) GP41 PF00517.17 ORX68313.1 - 3.9 7.3 9.8 21 5.0 9.9 1.7 1 1 0 1 1 1 0 Retroviral envelope protein MOSC_N PF03476.16 ORX68314.1 - 1.2e-29 102.6 0.0 2.1e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 ORX68314.1 - 4.7e-13 49.3 0.0 1.8e-12 47.4 0.0 1.9 1 1 0 1 1 1 1 MOSC domain RTC PF01137.21 ORX68315.1 - 1.9e-45 154.7 0.0 2.6e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ORX68315.1 - 2.6e-39 133.9 0.0 4.1e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain CHCH PF06747.13 ORX68316.1 - 0.0015 18.6 0.1 0.0061 16.7 0.1 1.8 1 1 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 ORX68316.1 - 0.039 14.2 0.1 0.047 13.9 0.1 1.2 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type GHMP_kinases_N PF00288.26 ORX68320.1 - 4.6e-11 42.8 0.2 1.2e-10 41.5 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX68320.1 - 0.00052 20.3 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal PGAP1 PF07819.13 ORX68321.1 - 2e-75 253.5 0.1 2.3e-75 253.2 0.1 1.1 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 ORX68321.1 - 4.2e-06 27.5 0.1 5.8e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX68321.1 - 0.00063 19.5 0.2 0.0054 16.4 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX68321.1 - 0.012 14.8 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 ORX68321.1 - 0.024 14.2 0.2 0.038 13.5 0.2 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ORX68321.1 - 0.025 14.4 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Lipase_3 PF01764.25 ORX68321.1 - 0.048 13.5 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 ORX68321.1 - 0.12 12.0 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_5 PF12695.7 ORX68321.1 - 0.15 11.9 0.3 0.29 10.9 0.2 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Aldose_epim PF01263.20 ORX68322.1 - 4.4e-41 141.1 0.0 4.9e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase DEAD PF00270.29 ORX68323.1 - 2.7e-27 95.6 0.0 1.2e-26 93.6 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX68323.1 - 6.9e-21 74.7 0.0 2.9e-20 72.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX68323.1 - 1.2e-13 51.1 0.6 2.4e-13 50.1 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX68323.1 - 0.00012 22.1 1.0 0.00028 20.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX68323.1 - 0.005 16.1 0.0 0.005 16.1 0.0 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 ORX68323.1 - 0.11 12.7 0.0 0.38 11.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain OHCU_decarbox PF09349.10 ORX68324.1 - 4.1e-43 147.5 0.1 4.7e-43 147.4 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Ada3 PF10198.9 ORX68324.1 - 0.052 13.7 0.0 0.1 12.8 0.0 1.4 1 1 0 1 1 1 0 Histone acetyltransferases subunit 3 HhH-GPD PF00730.25 ORX68324.1 - 0.1 13.0 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein A_deaminase PF00962.22 ORX68326.1 - 2e-99 333.0 0.0 4.7e-99 331.8 0.0 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase UPRTase PF14681.6 ORX68327.1 - 2.8e-78 262.1 0.0 3.3e-78 261.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ORX68327.1 - 4.9e-05 22.9 0.0 6.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF2012 PF09430.10 ORX68328.1 - 1.2e-18 67.4 0.0 1.5e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Joubert PF15392.6 ORX68329.1 - 6.3 6.4 10.7 0.2 11.3 3.4 1.8 1 1 1 2 2 2 0 Joubert syndrome-associated Peptidase_M18 PF02127.15 ORX68331.1 - 4.9e-147 490.2 0.0 6.1e-147 489.9 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ORX68331.1 - 0.13 11.2 0.0 7.1 5.5 0.0 3.0 2 1 0 2 2 2 0 M42 glutamyl aminopeptidase Pkinase PF00069.25 ORX68332.1 - 7.8e-49 166.4 0.0 5.9e-48 163.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX68332.1 - 2.3e-25 89.3 0.0 6.8e-24 84.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX68332.1 - 3.3e-07 29.9 0.0 1.1e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX68332.1 - 2.2e-06 26.7 0.0 2.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ORX68332.1 - 0.0012 18.0 0.1 0.0021 17.1 0.0 1.4 2 0 0 2 2 2 1 Seadornavirus VP7 APH PF01636.23 ORX68332.1 - 0.0013 18.7 0.1 0.13 12.2 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ORX68332.1 - 0.0042 16.7 0.0 0.077 12.6 0.0 2.1 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ORX68332.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FMN_red PF03358.15 ORX68333.1 - 1.8e-10 40.8 0.0 2.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 ORX68333.1 - 6.1e-05 23.3 0.2 0.00015 22.0 0.1 1.7 2 0 0 2 2 2 1 Flavodoxin Flavodoxin_2 PF02525.17 ORX68333.1 - 0.0026 17.5 0.0 0.0033 17.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ORX68333.1 - 0.014 15.6 0.0 2.8 8.2 0.2 2.1 1 1 1 2 2 2 0 Flavodoxin domain Ribosomal_L17 PF01196.19 ORX68334.1 - 6.2e-32 110.4 0.0 7.3e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L17 Pox_MCEL PF03291.16 ORX68334.1 - 0.15 11.1 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Rad52_Rad22 PF04098.15 ORX68335.1 - 6.4e-55 185.3 0.1 8.8e-55 184.8 0.1 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DUF2244 PF10003.9 ORX68337.1 - 0.0099 15.5 0.3 0.042 13.5 0.2 1.9 2 0 0 2 2 2 1 Integral membrane protein (DUF2244) 3HCDH_N PF02737.18 ORX68338.1 - 2.4e-35 122.1 0.3 3.7e-35 121.4 0.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ORX68338.1 - 2.1e-26 92.3 0.1 4.2e-25 88.2 0.0 2.4 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ANT PF03374.14 ORX68338.1 - 0.12 12.7 0.0 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain ABC_membrane_2 PF06472.15 ORX68339.1 - 2.6e-78 263.1 6.5 3.9e-78 262.6 6.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX68339.1 - 5.2e-17 62.7 0.0 1.1e-16 61.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ORX68339.1 - 0.00033 21.2 0.0 0.034 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain SbmA_BacA PF05992.12 ORX68339.1 - 0.001 18.6 0.4 0.0018 17.8 0.4 1.4 1 0 0 1 1 1 1 SbmA/BacA-like family SMC_N PF02463.19 ORX68339.1 - 0.0045 16.4 0.1 0.1 12.0 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX68339.1 - 0.0059 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 ORX68339.1 - 0.037 13.9 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 ORX68339.1 - 0.093 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 ORX68339.1 - 0.11 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX68339.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Phytochelatin PF05023.14 ORX68340.1 - 1.5e-29 102.7 0.0 1.9e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Phytochelatin synthase Peroxin-3 PF04882.12 ORX68342.1 - 2.4e-73 247.7 8.1 4.8e-34 118.2 1.3 3.2 1 1 2 3 3 3 3 Peroxin-3 Ysc84 PF04366.12 ORX68343.1 - 1.2e-43 148.0 0.1 2.4e-43 147.0 0.1 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ORX68343.1 - 4.2e-15 55.1 0.1 6.8e-15 54.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX68343.1 - 9.9e-14 50.9 0.0 1.6e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX68343.1 - 1.7e-12 46.8 0.0 3.1e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain AMPKBI PF04739.15 ORX68344.1 - 7.4e-29 99.8 1.9 1.1e-28 99.3 1.9 1.2 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 ORX68344.1 - 4.8e-26 90.8 0.1 7.5e-26 90.2 0.1 1.2 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase zf-RING_2 PF13639.6 ORX68346.1 - 4.8e-15 55.6 6.4 8.2e-15 54.9 6.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX68346.1 - 1.7e-12 46.8 3.2 1.7e-12 46.8 3.2 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX68346.1 - 1.2e-09 37.8 5.4 2.2e-09 37.0 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX68346.1 - 1.6e-09 37.5 4.5 2.7e-09 36.7 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX68346.1 - 6.9e-08 32.7 8.2 5.5e-07 29.8 8.2 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX68346.1 - 1.6e-07 31.2 4.1 2.5e-07 30.5 4.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain PA PF02225.22 ORX68346.1 - 5.5e-07 29.5 0.0 8.2e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 PA domain zf-C3HC4_3 PF13920.6 ORX68346.1 - 2.5e-06 27.3 6.9 3.9e-06 26.6 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX68346.1 - 8.3e-05 22.6 4.8 0.00022 21.2 4.8 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX68346.1 - 0.00013 21.9 0.7 0.00013 21.9 0.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 ORX68346.1 - 0.00086 19.1 6.7 0.0015 18.3 6.7 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RINGv PF12906.7 ORX68346.1 - 0.0019 18.3 2.7 0.0046 17.1 2.7 1.7 1 1 0 1 1 1 1 RING-variant domain Prok-RING_4 PF14447.6 ORX68346.1 - 0.0039 17.0 7.9 0.0077 16.1 7.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Baculo_RING PF05883.11 ORX68346.1 - 0.092 12.7 0.7 0.17 11.9 0.7 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-C3HC4_4 PF15227.6 ORX68346.1 - 0.096 12.9 1.9 0.26 11.5 1.9 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 ORX68346.1 - 0.17 11.8 5.4 0.37 10.7 5.4 1.6 1 0 0 1 1 1 0 PHD-finger CDP-OH_P_tran_2 PF08009.11 ORX68346.1 - 0.24 11.3 0.2 0.24 11.3 0.2 2.0 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 FANCL_C PF11793.8 ORX68346.1 - 0.28 11.4 8.3 1.7 8.9 8.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ORX68346.1 - 0.6 9.8 4.4 1.3 8.7 4.4 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 ORX68346.1 - 3.6 7.6 8.7 1.5 8.8 1.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 ORX68346.1 - 5.8 7.3 7.9 0.47 10.8 3.1 1.7 2 0 0 2 2 1 0 RING-like domain SpoIIIAH PF12685.7 ORX68347.1 - 0.043 13.6 1.2 0.064 13.1 1.2 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF2201_N PF13203.6 ORX68347.1 - 0.055 13.1 0.8 0.077 12.6 0.8 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain FRG2 PF15315.6 ORX68347.1 - 4.1 7.6 8.3 5.9 7.1 8.3 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 WD40 PF00400.32 ORX68348.1 - 4.9e-48 160.1 25.7 1.2e-08 35.4 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX68348.1 - 1.4e-10 41.3 1.6 0.0021 18.3 0.0 4.4 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX68348.1 - 1.6e-05 23.8 12.4 0.012 14.3 0.3 4.9 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX68348.1 - 0.0004 19.4 0.2 6.3 5.7 0.0 4.2 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ORX68348.1 - 0.0089 14.1 0.0 0.042 11.8 0.0 1.9 2 1 0 2 2 2 1 IKI3 family Leo1 PF04004.13 ORX68349.1 - 5.8e-29 101.1 0.0 5.8e-29 101.1 0.0 2.0 2 1 0 2 2 2 1 Leo1-like protein PIEZO PF15917.5 ORX68349.1 - 0.62 9.5 4.6 1.5 8.2 4.6 1.6 1 0 0 1 1 1 0 Piezo M16C_assoc PF08367.11 ORX68349.1 - 2.7 7.1 6.8 0.15 11.2 1.4 1.5 2 0 0 2 2 2 0 Peptidase M16C associated Gpi1 PF05024.15 ORX68350.1 - 1.9e-57 194.4 15.2 3.6e-57 193.5 15.2 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) ABC_membrane_2 PF06472.15 ORX68352.1 - 1.8e-70 237.4 6.3 7.1e-41 140.4 1.0 2.2 1 1 1 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX68352.1 - 4.9e-17 62.7 0.0 1.2e-16 61.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ORX68352.1 - 0.00062 20.3 0.6 0.038 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ORX68352.1 - 0.0047 16.4 0.1 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX68352.1 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 ORX68352.1 - 0.038 13.9 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 ORX68352.1 - 0.094 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 ORX68352.1 - 0.11 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX68352.1 - 0.14 11.7 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region 3HCDH PF00725.22 ORX68353.1 - 4.4e-34 117.0 0.0 9.5e-34 115.9 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 ORX68353.1 - 1.8e-29 102.9 1.7 6.4e-29 101.1 1.7 1.9 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C3HC4_3 PF13920.6 ORX68356.1 - 1.4e-10 40.9 6.6 1.9e-10 40.4 6.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX68356.1 - 2.2e-10 40.2 7.4 3.5e-10 39.5 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX68356.1 - 3e-09 37.1 7.0 5e-09 36.4 7.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ORX68356.1 - 1.9e-08 34.1 5.7 3.1e-08 33.4 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX68356.1 - 1.4e-07 31.2 5.3 2.3e-07 30.6 5.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX68356.1 - 4.1e-07 29.8 7.6 6.8e-07 29.1 7.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ORX68356.1 - 4.5e-07 29.8 3.2 4.5e-07 29.8 3.2 2.1 1 1 1 2 2 2 1 RING-type zinc-finger Rtf2 PF04641.12 ORX68356.1 - 0.00058 19.3 0.8 0.00084 18.8 0.8 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-rbx1 PF12678.7 ORX68356.1 - 0.0026 18.0 3.5 0.0046 17.2 3.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ORX68356.1 - 0.0039 16.9 2.7 0.0039 16.9 2.7 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_10 PF16685.5 ORX68356.1 - 0.0068 16.5 6.6 0.013 15.6 6.6 1.5 1 1 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 ORX68356.1 - 0.031 14.1 5.3 0.059 13.2 5.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ORX68356.1 - 0.036 14.2 6.2 0.12 12.5 6.4 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ORX68356.1 - 0.28 11.1 7.0 0.46 10.4 7.0 1.2 1 0 0 1 1 1 0 zf-RING of BARD1-type protein LCE6A PF15858.5 ORX68356.1 - 5 8.0 9.1 0.39 11.5 3.4 2.2 2 0 0 2 2 1 0 Late cornified envelope protein 6A family Ldh_1_N PF00056.23 ORX68357.1 - 2e-44 151.1 0.5 2.8e-44 150.6 0.5 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ORX68357.1 - 3.9e-33 114.8 0.1 5.3e-31 107.8 0.1 2.2 1 1 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 ORX68357.1 - 0.00013 21.1 0.0 0.00018 20.6 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ORX68357.1 - 0.0014 18.5 0.3 0.052 13.4 0.1 2.4 2 1 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ORX68357.1 - 0.0069 16.8 0.1 0.048 14.1 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain PPTA PF01239.22 ORX68358.1 - 3.3e-32 109.2 16.0 4.8e-08 32.5 0.0 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Inv-AAD PF18785.1 ORX68359.1 - 4.3e-28 97.8 0.5 7.8e-28 96.9 0.5 1.4 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 ORX68359.1 - 2.8e-20 72.0 0.5 3.5e-20 71.8 0.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX68359.1 - 9.5e-10 38.4 0.1 1.2e-09 38.1 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 ORX68359.1 - 0.15 12.0 0.2 0.3 11.0 0.2 1.5 1 1 0 1 1 1 0 APOBEC-like N-terminal domain BIR PF00653.21 ORX68360.1 - 6.9e-41 138.8 2.2 4.7e-21 75.2 0.1 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 ORX68360.1 - 0.0068 16.5 2.2 0.18 11.8 0.0 2.9 1 1 1 2 2 2 1 C3HC zinc finger-like LRR_4 PF12799.7 ORX68361.1 - 1.8e-20 72.7 11.3 0.00033 21.0 0.3 8.9 6 2 5 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX68361.1 - 4.6e-20 71.1 14.2 2.2e-07 30.5 0.6 7.1 7 1 0 8 8 8 5 Leucine rich repeat LRR_9 PF14580.6 ORX68361.1 - 6.2e-08 32.3 6.3 0.0024 17.4 0.1 4.2 4 1 1 5 5 5 3 Leucine-rich repeat LRR_1 PF00560.33 ORX68361.1 - 0.42 11.4 15.0 21 6.2 0.1 7.5 9 0 0 9 9 9 0 Leucine Rich Repeat Ras PF00071.22 ORX68362.1 - 4.5e-43 146.6 0.0 5.8e-43 146.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX68362.1 - 4.8e-13 49.4 0.0 7.5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX68362.1 - 0.00034 20.1 0.0 0.00051 19.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX68362.1 - 0.00074 19.1 0.0 0.0008 19.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain TIR_2 PF13676.6 ORX68362.1 - 0.09 13.4 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 TIR domain IDO PF01231.18 ORX68363.1 - 2.1e-123 412.3 0.0 2.7e-123 412.0 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Peptidase_S26 PF10502.9 ORX68365.1 - 2.8e-06 27.2 0.0 0.00033 20.4 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 ORX68365.1 - 1.5e-05 24.9 0.0 2.9e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase S24-like ADH_zinc_N PF00107.26 ORX68366.1 - 1.8e-20 73.3 2.2 8.6e-20 71.0 2.2 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX68366.1 - 2.1e-16 59.7 0.0 5e-16 58.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX68366.1 - 2.7e-14 54.4 0.0 4.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NADH_Oxid_Nqo15 PF11497.8 ORX68367.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 MFS_1 PF07690.16 ORX68368.1 - 9.6e-21 74.1 26.9 9.6e-21 74.1 26.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1686 PF07937.11 ORX68368.1 - 5.5 6.8 9.5 0.42 10.5 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1686) Frag1 PF10277.9 ORX68369.1 - 2.9e-34 118.5 12.4 3.3e-34 118.3 12.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Nop PF01798.18 ORX68370.1 - 6.3e-84 281.0 0.1 6.3e-84 281.0 0.1 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ORX68370.1 - 2.4e-23 82.3 1.7 2.4e-23 82.3 1.7 2.5 2 1 0 2 2 2 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 ORX68370.1 - 0.0071 16.5 38.4 0.014 15.5 38.4 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 GldM_C PF12080.8 ORX68370.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 GldM C-terminal domain NARP1 PF12569.8 ORX68370.1 - 0.51 9.2 24.6 0.79 8.6 24.6 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2722 PF10846.8 ORX68370.1 - 2.7 6.8 21.8 3.6 6.4 21.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RR_TM4-6 PF06459.12 ORX68370.1 - 3.8 7.3 24.6 6.4 6.5 24.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CAF1 PF04857.20 ORX68371.1 - 3.7e-64 216.9 1.6 5.2e-34 117.9 0.1 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.20 ORX68371.1 - 0.01 15.6 0.0 4.3 7.0 0.0 2.4 2 0 0 2 2 2 0 3'-5' exonuclease CDC45 PF02724.14 ORX68371.1 - 0.92 7.7 7.0 1.3 7.2 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein ABC_tran PF00005.27 ORX68372.1 - 2.2e-14 54.2 0.0 5e-14 53.0 0.0 1.5 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68372.1 - 0.094 12.1 0.1 0.87 9.0 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 ORX68373.1 - 1.6e-30 106.4 0.0 2.8e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68373.1 - 9e-07 28.5 0.5 5.8e-05 22.6 0.5 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX68373.1 - 0.0001 22.3 0.4 0.00049 20.2 0.3 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX68373.1 - 0.0028 18.1 0.0 0.0045 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 ORX68373.1 - 0.003 17.7 1.2 0.0062 16.6 1.2 1.8 1 1 0 1 1 1 1 Helicase HerA, central domain IstB_IS21 PF01695.17 ORX68373.1 - 0.0032 17.2 0.1 0.14 11.9 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_21 PF13304.6 ORX68373.1 - 0.0045 16.8 0.6 0.18 11.6 0.1 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX68373.1 - 0.015 15.5 1.0 0.35 11.1 1.0 2.2 1 1 0 1 1 1 0 AAA domain FKBP_N_2 PF18023.1 ORX68373.1 - 0.021 14.9 0.0 0.059 13.5 0.0 1.7 2 0 0 2 2 2 0 BDBT FKBP like N-terminal AAA_29 PF13555.6 ORX68373.1 - 0.065 13.0 0.3 0.21 11.4 0.2 1.9 1 1 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ORX68373.1 - 0.069 12.9 0.9 0.33 10.6 0.9 2.1 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 ORX68373.1 - 0.083 11.9 0.1 0.16 10.9 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 ORX68373.1 - 0.11 11.7 1.2 6.8 5.8 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 ORX68373.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 ORX68373.1 - 0.22 12.0 0.1 0.36 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX68373.1 - 0.25 11.9 0.6 0.85 10.2 0.6 2.2 1 1 0 1 1 1 0 AAA domain Peptidase_M3 PF01432.20 ORX68374.1 - 1.1e-134 450.2 0.0 1.5e-134 449.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 GTP_EFTU PF00009.27 ORX68375.1 - 1.9e-49 167.9 0.1 3e-49 167.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX68375.1 - 2.6e-34 117.6 0.0 8.8e-34 115.9 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ORX68375.1 - 6.2e-21 74.2 0.0 2.3e-20 72.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX68375.1 - 3.5e-14 52.9 0.0 1.6e-13 50.8 0.0 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ORX68375.1 - 0.00087 19.3 0.0 0.0021 18.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ORX68375.1 - 0.043 13.9 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Mob1_phocein PF03637.17 ORX68376.1 - 1.2e-64 217.4 0.7 1.4e-64 217.2 0.7 1.0 1 0 0 1 1 1 1 Mob1/phocein family BAR PF03114.18 ORX68377.1 - 1.3e-28 100.3 6.1 1.6e-28 100.0 6.1 1.1 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 ORX68377.1 - 0.00029 20.6 3.5 0.00041 20.1 3.5 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 ORX68377.1 - 0.0023 17.5 2.4 0.016 14.8 0.1 2.2 2 0 0 2 2 2 1 Arfaptin-like domain BAR_3_WASP_bdg PF10456.9 ORX68377.1 - 0.022 14.2 0.3 0.039 13.4 0.3 1.5 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein DUF1090 PF06476.12 ORX68377.1 - 0.099 12.8 1.8 0.14 12.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) TYA PF01021.19 ORX68377.1 - 0.12 12.7 0.0 0.39 11.1 0.0 1.9 2 0 0 2 2 2 0 TYA transposon protein XhlA PF10779.9 ORX68377.1 - 0.13 12.5 2.4 0.46 10.7 0.2 2.5 2 1 0 2 2 2 0 Haemolysin XhlA Amino_oxidase PF01593.24 ORX68378.1 - 7.1e-07 28.9 0.0 9.7e-07 28.4 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FHA_2 PF17913.1 ORX68379.1 - 0.092 13.0 0.2 0.71 10.1 0.0 2.4 3 0 0 3 3 3 0 FHA domain Methyltransf_12 PF08242.12 ORX68380.1 - 1.5e-16 61.0 0.0 3.1e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX68380.1 - 6.7e-14 52.1 0.0 9e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX68380.1 - 2.7e-13 50.4 0.0 4.8e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX68380.1 - 4.9e-11 43.1 0.0 8.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX68380.1 - 4.6e-08 33.0 0.0 6.5e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX68380.1 - 4.6e-06 26.3 0.0 8.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX68380.1 - 0.00013 21.5 0.0 0.00057 19.4 0.0 2.0 2 1 1 3 3 3 1 Putative methyltransferase Pox_MCEL PF03291.16 ORX68380.1 - 0.009 15.2 0.0 0.014 14.5 0.0 1.5 1 1 0 1 1 1 1 mRNA capping enzyme Met_10 PF02475.16 ORX68380.1 - 0.087 12.6 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_24 PF13578.6 ORX68380.1 - 0.088 13.8 0.0 0.15 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 ORX68380.1 - 0.14 11.8 0.2 0.39 10.3 0.2 1.8 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) ADH_zinc_N PF00107.26 ORX68381.1 - 2.5e-28 98.7 0.2 4.6e-28 97.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX68381.1 - 6.8e-10 40.1 0.0 1.6e-09 38.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX68381.1 - 4.4e-09 36.2 0.0 1.1e-08 34.9 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase NAD_binding_10 PF13460.6 ORX68381.1 - 0.068 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H-binding TrkA_N PF02254.18 ORX68381.1 - 0.072 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain SAD_SRA PF02182.17 ORX68382.1 - 7.4e-20 71.2 0.0 1.6e-19 70.2 0.0 1.5 2 0 0 2 2 2 1 SAD/SRA domain zf-C3HC4_2 PF13923.6 ORX68382.1 - 3.7e-05 23.5 18.0 7.5e-05 22.5 18.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX68382.1 - 0.00056 19.9 14.4 0.0012 18.8 14.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX68382.1 - 0.004 17.0 15.0 0.0077 16.1 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX68382.1 - 0.0045 17.1 16.1 0.0086 16.2 16.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ORX68382.1 - 0.01 15.7 17.9 0.021 14.7 17.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MutS_V PF00488.21 ORX68382.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 MutS domain V zf-RING_2 PF13639.6 ORX68382.1 - 0.38 11.1 16.8 0.73 10.2 16.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 ORX68382.1 - 0.51 10.4 17.9 0.48 10.4 16.2 1.8 2 0 0 2 2 2 0 zinc-RING finger domain ADH_zinc_N PF00107.26 ORX68383.1 - 7e-26 90.7 0.1 1e-25 90.2 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX68383.1 - 2e-20 72.7 0.0 4.9e-20 71.5 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX68383.1 - 1.2e-06 29.6 0.0 5e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PDZ_1 PF12812.7 ORX68384.1 - 6e-39 131.9 0.0 3.9e-23 81.3 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 ORX68384.1 - 1.1e-20 75.1 0.0 3e-19 70.4 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 ORX68384.1 - 4.3e-18 64.9 0.1 1.1e-08 34.8 0.3 4.5 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 ORX68384.1 - 3e-12 46.7 0.4 6.2e-05 23.2 0.2 4.1 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 ORX68384.1 - 1.9e-07 31.3 0.0 0.00027 21.2 0.0 3.0 3 0 0 3 3 3 2 PDZ domain Trypsin PF00089.26 ORX68384.1 - 0.0024 17.7 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 ORX68384.1 - 0.025 14.6 0.5 0.65 10.0 0.2 3.1 4 0 0 4 4 4 0 Tricorn protease PDZ domain DUF31 PF01732.16 ORX68384.1 - 0.25 10.9 0.1 0.39 10.2 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Cyclin PF08613.11 ORX68385.1 - 3.2e-08 34.1 0.1 5.2e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX68385.1 - 1.3e-06 28.2 0.4 2.1e-06 27.5 0.4 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain SPC25 PF06703.11 ORX68385.1 - 0.095 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Rep_fac-A_3 PF08661.11 ORX68386.1 - 1.2e-17 64.2 0.0 1.4e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 OPT PF03169.15 ORX68387.1 - 1.4e-122 410.4 33.9 1.5e-121 407.0 33.9 1.9 1 1 0 1 1 1 1 OPT oligopeptide transporter protein ATP-grasp_2 PF08442.10 ORX68388.1 - 2.7e-56 190.3 1.8 2.6e-55 187.1 0.3 2.3 1 1 1 2 2 2 2 ATP-grasp domain Ligase_CoA PF00549.19 ORX68388.1 - 7.6e-21 74.5 0.0 1.5e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ORX68388.1 - 4.9e-07 29.4 0.2 2.9e-05 23.6 0.0 2.6 1 1 1 2 2 2 1 ATP-grasp domain NAD_synthase PF02540.17 ORX68388.1 - 0.035 13.2 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD synthase DUF2922 PF11148.8 ORX68388.1 - 0.14 11.9 0.0 0.45 10.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) TIP120 PF08623.10 ORX68389.1 - 1.6e-33 115.9 8.8 2.2e-33 115.4 0.1 4.5 4 2 2 6 6 6 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 ORX68389.1 - 2.7e-09 37.3 9.7 0.23 11.8 0.0 6.5 5 1 0 5 5 5 4 HEAT repeats HEAT PF02985.22 ORX68389.1 - 3.6e-08 33.0 5.5 3 8.4 0.1 7.1 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 ORX68389.1 - 2.5e-06 27.8 13.2 0.56 10.8 0.1 7.4 7 0 0 7 7 7 1 HEAT-like repeat Cnd3 PF12719.7 ORX68389.1 - 9.7e-05 21.7 0.1 0.049 12.8 0.0 3.7 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 ORX68389.1 - 0.00026 21.1 3.4 0.0053 16.9 0.1 4.0 3 2 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ORX68389.1 - 0.00036 20.6 12.9 0.15 12.1 3.3 4.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 STAT_int PF02865.17 ORX68389.1 - 0.027 14.9 2.4 3 8.3 0.0 3.4 3 0 0 3 3 3 0 STAT protein, protein interaction domain Arm PF00514.23 ORX68389.1 - 0.083 13.0 0.0 5 7.3 0.0 3.3 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 ORX68389.1 - 0.12 12.7 0.0 11 6.5 0.0 4.2 4 0 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain WGG PF10273.9 ORX68390.1 - 2.9e-27 95.1 0.2 5.4e-27 94.3 0.2 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 Snf7 PF03357.21 ORX68391.1 - 4.8e-33 114.2 22.9 4.8e-33 114.2 22.9 1.5 1 1 1 2 2 2 1 Snf7 DUF3418 PF11898.8 ORX68391.1 - 0.0028 16.4 6.4 0.0031 16.2 6.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3418) Neugrin PF06413.11 ORX68391.1 - 0.0093 16.0 5.7 0.011 15.8 5.7 1.1 1 0 0 1 1 1 1 Neugrin BPL_N PF09825.9 ORX68391.1 - 0.17 10.9 1.3 0.23 10.5 0.2 1.6 1 1 1 2 2 2 0 Biotin-protein ligase, N terminal Mod_r PF07200.13 ORX68391.1 - 1.5 8.9 8.8 8 6.6 8.4 2.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DNA_pol_phi PF04931.13 ORX68391.1 - 2 6.4 17.5 2.6 6.1 17.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mpv17_PMP22 PF04117.12 ORX68392.1 - 5.2e-09 36.2 4.6 6.8e-09 35.8 3.1 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family ADSL_C PF10397.9 ORX68392.1 - 0.083 13.4 0.1 0.15 12.6 0.1 1.5 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminus Chitin_synth_2 PF03142.15 ORX68393.1 - 1.7e-198 660.6 0.1 1.9e-198 660.4 0.1 1.0 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX68393.1 - 2.1e-12 47.4 0.1 4.2e-10 39.9 0.1 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX68393.1 - 2.9e-10 40.4 11.9 9.6e-10 38.7 11.9 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX68393.1 - 1.4e-08 34.7 0.1 0.0003 20.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX68393.1 - 0.0034 16.9 0.1 0.18 11.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Ank_2 PF12796.7 ORX68394.1 - 0.00039 20.9 0.1 0.00057 20.4 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX68394.1 - 0.0008 19.7 0.0 0.0051 17.2 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ORX68394.1 - 0.0031 17.8 0.0 0.0063 16.8 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX68394.1 - 0.011 16.3 0.1 0.034 14.7 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Chs7 PF12271.8 ORX68395.1 - 1.2e-107 359.6 25.2 1.3e-107 359.4 25.2 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Vps53_N PF04100.12 ORX68396.1 - 8.8e-73 245.4 0.0 1.6e-72 244.6 0.0 1.4 2 0 0 2 2 2 1 Vps53-like, N-terminal Sec6 PF06046.13 ORX68396.1 - 9.9e-07 27.5 0.0 0.0002 19.9 0.0 2.3 2 0 0 2 2 2 2 Exocyst complex component Sec6 RINT1_TIP1 PF04437.13 ORX68396.1 - 0.13 11.1 0.0 0.21 10.4 0.0 1.5 1 1 0 1 1 1 0 RINT-1 / TIP-1 family VPS53_C PF16854.5 ORX68396.1 - 0.2 11.5 0.0 0.7 9.7 0.0 1.9 1 1 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF4315 PF14193.6 ORX68396.1 - 0.37 10.8 1.6 1 9.4 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) Cyclin_N PF00134.23 ORX68397.1 - 7.9e-14 51.5 0.4 7.9e-14 51.5 0.4 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 ORX68397.1 - 1.6e-05 24.8 1.9 0.0022 18.0 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Tctex-1 PF03645.13 ORX68398.1 - 1.4e-23 83.1 0.0 1.7e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Pribosyltran PF00156.27 ORX68399.1 - 5e-16 58.6 0.1 6.3e-16 58.3 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PHD PF00628.29 ORX68400.1 - 1e-07 31.7 6.2 1e-07 31.7 6.2 1.9 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 ORX68400.1 - 5.6e-07 29.0 1.6 1e-06 28.2 1.6 1.4 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 ORX68400.1 - 0.13 12.3 0.8 0.29 11.2 0.8 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger zf-BED PF02892.15 ORX68400.1 - 0.24 11.4 2.6 0.5 10.4 1.4 2.0 2 0 0 2 2 2 0 BED zinc finger Rubredoxin PF00301.20 ORX68400.1 - 2.2 8.4 4.4 0.74 9.9 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin SUIM_assoc PF16619.5 ORX68400.1 - 3.3 7.8 13.0 9.5 6.4 3.8 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-CSL PF05207.13 ORX68400.1 - 4.3 7.1 8.9 1.9 8.3 5.5 2.2 2 1 0 2 2 2 0 CSL zinc finger DnaJ PF00226.31 ORX68401.1 - 8.3e-22 77.1 2.1 2e-21 75.9 2.1 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 ORX68401.1 - 2.6e-18 64.6 0.6 0.00075 19.4 1.1 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX68401.1 - 4.7e-18 65.4 2.7 1.3e-05 25.6 0.0 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX68401.1 - 5.7e-17 60.7 4.0 6.1e-05 22.7 0.0 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX68401.1 - 5.4e-15 54.8 0.8 2.4e-05 23.9 0.0 3.9 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 ORX68401.1 - 1.2e-13 50.4 2.2 0.0012 19.1 0.2 4.9 6 0 0 6 6 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX68401.1 - 3.5e-13 49.2 4.6 0.43 11.5 0.0 6.9 3 3 4 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX68401.1 - 3.9e-10 40.2 2.0 0.0017 19.0 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX68401.1 - 4.2e-08 33.2 0.1 0.11 12.7 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX68401.1 - 7.6e-08 32.0 7.4 0.025 14.8 0.0 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX68401.1 - 1.8e-06 27.9 0.4 0.071 13.2 0.0 4.6 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 ORX68401.1 - 9.1e-05 22.9 0.7 22 6.0 0.1 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX68401.1 - 0.0006 20.0 4.6 0.051 13.9 0.2 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX68401.1 - 0.0063 16.5 0.9 0.8 9.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX68401.1 - 0.0066 16.8 6.4 0.27 11.6 0.1 4.1 3 2 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX68401.1 - 0.0069 16.6 3.3 10 6.4 1.1 4.2 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ORX68401.1 - 0.1 12.4 1.0 0.77 9.6 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) DUF357 PF04010.13 ORX68401.1 - 0.28 11.3 3.0 17 5.6 0.1 3.6 3 1 1 4 4 3 0 Protein of unknown function (DUF357) HEPN PF05168.14 ORX68401.1 - 0.44 10.7 6.8 14 5.8 2.6 3.9 2 2 0 2 2 2 0 HEPN domain NRBF2_MIT PF17169.4 ORX68401.1 - 2 8.7 5.1 2.5 8.4 0.1 3.3 4 0 0 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 PQ-loop PF04193.14 ORX68403.1 - 7.2e-06 25.7 4.1 0.0021 17.8 0.2 2.8 2 1 0 2 2 2 2 PQ loop repeat Pkinase PF00069.25 ORX68404.1 - 2.9e-46 158.0 0.0 3e-44 151.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX68404.1 - 1e-33 116.7 0.0 1.4e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX68404.1 - 3e-07 29.6 0.1 6.8e-07 28.4 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX68404.1 - 8.3e-06 25.3 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX68404.1 - 0.00092 19.2 0.1 0.002 18.1 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family 2OG-FeII_Oxy_3 PF13640.6 ORX68405.1 - 9.2e-09 36.1 0.0 1.5e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4451 PF14616.6 ORX68406.1 - 2.8e-06 27.6 0.1 5.2e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Homeodomain PF00046.29 ORX68407.1 - 7.8e-17 60.9 5.1 2.2e-16 59.4 5.1 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX68407.1 - 0.06 13.3 0.4 0.18 11.7 0.4 1.8 1 0 0 1 1 1 0 Homeobox KN domain Ribosomal_L37ae PF01780.19 ORX68408.1 - 6.5e-41 138.3 11.7 7.5e-41 138.1 11.7 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 ORX68408.1 - 0.0012 18.9 2.7 0.0018 18.4 2.7 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 ORX68408.1 - 0.0019 18.2 1.6 0.0035 17.3 1.6 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain UPF0004 PF00919.20 ORX68408.1 - 0.054 13.5 0.2 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein family UPF0004 zf-BED PF02892.15 ORX68408.1 - 0.12 12.5 5.5 2.5 8.2 0.8 2.2 1 1 1 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.6 ORX68408.1 - 0.59 10.7 3.5 3 8.4 0.7 2.2 1 1 1 2 2 2 0 Zinc-finger double domain zf-Sec23_Sec24 PF04810.15 ORX68408.1 - 1.7 8.8 5.1 7.3 6.7 0.2 2.2 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger Lipase_3 PF01764.25 ORX68409.1 - 1.3e-28 99.6 0.0 1.7e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ORX68409.1 - 0.0041 16.4 0.0 0.0069 15.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 ORX68409.1 - 0.0053 16.3 0.0 0.0074 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Gly_acyl_tr_N PF06021.11 ORX68409.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase FA_desaturase PF00487.24 ORX68410.1 - 2.8e-24 86.3 14.8 4.2e-24 85.8 14.8 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 ORX68410.1 - 1.7e-11 43.4 0.2 3.5e-11 42.4 0.2 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) PDZ_1 PF12812.7 ORX68411.1 - 5.8e-37 125.6 0.0 9.7e-25 86.4 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 ORX68411.1 - 1.9e-18 67.8 0.1 7.8e-18 65.8 0.0 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 ORX68411.1 - 1.5e-15 56.8 2.1 7e-10 38.6 0.4 4.8 5 0 0 5 5 5 3 PDZ domain PDZ_2 PF13180.6 ORX68411.1 - 7.5e-10 39.0 0.2 0.00023 21.4 0.4 4.5 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 ORX68411.1 - 0.0029 17.9 0.2 0.12 12.8 0.2 3.1 3 0 0 3 3 3 1 PDZ domain Tricorn_PDZ PF14685.6 ORX68411.1 - 0.036 14.0 0.3 0.46 10.5 0.1 2.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain Guanylate_kin PF00625.21 ORX68412.1 - 3.2e-50 170.3 0.4 6.6e-50 169.3 0.4 1.5 1 1 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 ORX68412.1 - 8.5e-07 29.2 0.6 0.0001 22.5 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX68412.1 - 4.2e-06 27.3 0.0 8.2e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX68412.1 - 1.1e-05 25.7 0.0 1.8e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ORX68412.1 - 1.4e-05 25.2 0.1 0.00021 21.3 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX68412.1 - 0.00012 22.5 0.0 0.00014 22.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ORX68412.1 - 0.00022 21.0 0.2 0.00029 20.6 0.2 1.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX68412.1 - 0.00027 21.5 0.0 0.00039 20.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter DUF2075 PF09848.9 ORX68412.1 - 0.00034 20.0 0.1 0.064 12.5 0.0 2.1 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 ORX68412.1 - 0.00048 20.1 0.0 0.0011 18.9 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase ATPase_2 PF01637.18 ORX68412.1 - 0.00054 20.0 0.8 0.00092 19.2 0.8 1.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ORX68412.1 - 0.00089 19.3 0.0 0.0015 18.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX68412.1 - 0.0013 19.0 0.1 0.0018 18.5 0.1 1.5 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ORX68412.1 - 0.0025 18.2 0.0 0.006 17.0 0.0 1.8 1 1 0 1 1 1 1 RNA helicase AAA PF00004.29 ORX68412.1 - 0.0047 17.3 0.1 0.0084 16.5 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ORX68412.1 - 0.0052 16.5 1.0 0.026 14.3 0.1 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_7 PF12775.7 ORX68412.1 - 0.0053 16.3 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 ORX68412.1 - 0.0098 15.9 0.1 0.074 13.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.15 ORX68412.1 - 0.01 14.6 0.0 0.018 13.9 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_21 PF13304.6 ORX68412.1 - 0.015 15.2 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Gtr1_RagA PF04670.12 ORX68412.1 - 0.018 14.4 0.0 0.06 12.7 0.0 1.8 2 1 1 3 3 3 0 Gtr1/RagA G protein conserved region NACHT PF05729.12 ORX68412.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ORX68412.1 - 0.018 14.6 0.1 0.28 10.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 ORX68412.1 - 0.019 14.7 0.2 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase SRPRB PF09439.10 ORX68412.1 - 0.024 14.0 0.4 0.39 10.1 0.0 2.6 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 ORX68412.1 - 0.039 14.5 5.0 0.34 11.4 5.0 2.3 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 ORX68412.1 - 0.04 13.8 0.0 0.86 9.4 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase Cytidylate_kin PF02224.18 ORX68412.1 - 0.042 13.6 0.2 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase Roc PF08477.13 ORX68412.1 - 0.049 13.8 0.1 0.19 11.9 0.0 2.0 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 ORX68412.1 - 0.081 13.3 0.1 0.21 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX68412.1 - 0.092 12.4 0.1 0.22 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 ORX68412.1 - 0.1 13.0 0.8 1.1 9.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 ORX68412.1 - 0.12 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein T2SSE PF00437.20 ORX68412.1 - 0.17 10.9 0.7 0.43 9.6 0.1 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Ribosomal_S7 PF00177.21 ORX68413.1 - 1.9e-38 131.4 0.7 2.4e-38 131.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e CRAL_TRIO PF00650.20 ORX68414.1 - 9.4e-37 126.2 0.0 1.2e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ORX68414.1 - 0.00017 21.8 0.0 0.00024 21.3 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain FAM83 PF07894.12 ORX68414.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 FAM83 A-H Isochorismatase PF00857.20 ORX68415.1 - 7.5e-15 55.5 0.8 7.9e-14 52.2 0.8 2.3 1 1 0 1 1 1 1 Isochorismatase family Glyco_transf_49 PF13896.6 ORX68415.1 - 0.092 12.1 0.2 0.58 9.5 0.0 2.0 2 0 0 2 2 2 0 Glycosyl-transferase for dystroglycan Med23 PF11573.8 ORX68416.1 - 1.2e-15 56.3 0.5 4.2e-14 51.3 0.2 2.4 2 0 0 2 2 2 2 Mediator complex subunit 23 Tox-MPTase3 PF15639.6 ORX68416.1 - 0.23 11.3 0.0 0.46 10.3 0.0 1.4 1 0 0 1 1 1 0 Metallopeptidase toxin 3 F-box_4 PF15966.5 ORX68417.1 - 0.00069 19.5 0.1 0.0013 18.6 0.1 1.4 1 0 0 1 1 1 1 F-box DUF1729 PF08354.10 ORX68419.1 - 3.5e-144 480.1 0.0 7.3e-144 479.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX68419.1 - 7.4e-52 176.0 6.8 2.8e-26 92.8 0.1 5.3 2 2 0 2 2 2 2 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX68419.1 - 2.4e-33 115.5 4.7 3.6e-31 108.4 4.7 2.5 1 1 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX68419.1 - 7.1e-28 96.6 0.1 9.4e-27 93.0 0.0 2.7 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 ORX68419.1 - 7.4e-26 91.3 0.2 1.4e-25 90.5 0.2 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 ORX68419.1 - 9.7e-25 87.1 0.0 2.1e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain Acyl_transf_1 PF00698.21 ORX68419.1 - 8.8e-16 58.3 1.7 3.9e-07 29.9 0.0 5.1 3 1 1 4 4 4 2 Acyl transferase domain Ketoacyl-synt_C PF02801.22 ORX68419.1 - 1.1e-13 51.2 0.0 4.1e-13 49.4 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 ORX68419.1 - 1.6e-11 44.3 0.0 3.4e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydrat_N PF13452.6 ORX68419.1 - 0.00044 20.4 0.4 0.0086 16.2 0.1 3.0 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX68419.1 - 0.0012 18.8 0.1 0.0028 17.6 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta RRM_1 PF00076.22 ORX68420.1 - 2e-26 91.6 0.9 3.3e-13 49.3 0.0 5.2 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMgT PF10270.9 ORX68421.1 - 1.8e-11 44.3 0.0 2.2e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter CBS PF00571.28 ORX68422.1 - 1.2e-21 76.9 6.8 1.1e-09 38.5 0.3 4.2 3 1 1 4 4 4 4 CBS domain Transferase PF02458.15 ORX68456.1 - 0.00011 21.0 0.1 0.00012 20.9 0.1 1.1 1 0 0 1 1 1 1 Transferase family MFS_1 PF07690.16 ORX68457.1 - 3.5e-24 85.4 23.8 3.5e-24 85.4 23.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily SLATT_4 PF18186.1 ORX68457.1 - 0.063 12.9 0.2 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 adh_short PF00106.25 ORX68458.1 - 4.6e-39 133.9 0.0 6.6e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX68458.1 - 1.3e-19 70.7 0.0 1.8e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX68458.1 - 9.2e-07 28.9 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX68458.1 - 0.00021 20.8 0.1 0.15 11.4 0.0 2.1 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) Sacchrp_dh_NADP PF03435.18 ORX68458.1 - 0.011 16.0 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 ORX68459.1 - 1.2e-16 60.7 0.0 1.5e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX68459.1 - 8.2e-11 41.9 0.0 1.1e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Cas_csx3 PF09620.10 ORX68459.1 - 0.035 14.0 0.3 3.5 7.6 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_csx3) FinO_N PF12602.8 ORX68459.1 - 0.26 11.6 1.3 1.5 9.1 0.2 2.6 2 0 0 2 2 2 0 Fertility inhibition protein N terminal NUDIX PF00293.28 ORX68460.1 - 1.5e-12 47.7 0.0 2.3e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain SPRY PF00622.28 ORX68461.1 - 2.9e-13 50.0 0.3 8.2e-13 48.5 0.3 1.8 1 0 0 1 1 1 1 SPRY domain Cnd3 PF12719.7 ORX68461.1 - 8.5e-05 21.9 0.5 0.012 14.8 0.0 2.3 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 ORX68461.1 - 1.1 9.7 4.0 5.4 7.5 0.7 3.2 2 0 0 2 2 2 0 HEAT repeats Pre-PUA PF17832.1 ORX68462.1 - 5.2e-26 91.2 0.1 8.4e-26 90.5 0.1 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 ORX68462.1 - 2.9e-20 72.0 0.1 4.2e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 ORX68462.1 - 0.1 12.9 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) ETC_C1_NDUFA4 PF04800.12 ORX68463.1 - 3.6e-34 116.9 0.7 4.3e-34 116.7 0.7 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region RSN1_7TM PF02714.15 ORX68464.1 - 7e-66 222.3 28.1 1.1e-65 221.6 28.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX68464.1 - 7.3e-29 100.6 5.8 7.3e-29 100.6 5.8 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX68464.1 - 1.5e-18 67.6 0.0 7.6e-18 65.3 0.0 2.1 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Arrestin_N PF00339.29 ORX68465.1 - 8.7e-12 45.3 0.0 3.1e-11 43.5 0.0 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX68465.1 - 1.8e-06 28.4 0.1 0.0004 20.8 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Cu-oxidase_3 PF07732.15 ORX68466.1 - 5.7e-36 123.1 4.1 1.1e-32 112.5 0.3 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX68466.1 - 1.6e-32 112.1 3.0 1.6e-32 112.1 3.0 3.6 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX68466.1 - 1.3e-25 90.4 0.2 4.9e-24 85.2 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase DUF108 PF01958.18 ORX68466.1 - 0.038 14.4 0.1 0.47 10.9 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function DUF108 Cupredoxin_1 PF13473.6 ORX68466.1 - 0.14 12.3 0.0 2.2 8.4 0.0 2.5 2 1 0 2 2 2 0 Cupredoxin-like domain PEHE PF15275.6 ORX68467.1 - 0.0018 18.9 2.5 0.0018 18.9 2.5 2.2 2 0 0 2 2 2 1 PEHE domain KI67R PF08065.12 ORX68467.1 - 0.19 12.3 1.8 0.42 11.2 0.1 2.2 1 1 1 2 2 2 0 KI67R (NUC007) repeat SLD3 PF08639.10 ORX68468.1 - 0.23 10.2 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 MARVEL PF01284.23 ORX68469.1 - 7.9e-10 38.9 8.3 1.2e-09 38.4 8.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain CH PF00307.31 ORX68470.1 - 1.7e-78 259.9 0.0 4.8e-19 68.5 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ORX68470.1 - 2.2e-06 27.4 0.0 0.013 15.3 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_7 PF13499.6 ORX68470.1 - 0.012 16.0 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair RTA1 PF04479.13 ORX68470.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 RTA1 like protein IBR PF01485.21 ORX68471.1 - 6.1e-19 68.0 31.9 4.5e-11 42.8 4.8 4.4 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 ORX68471.1 - 7.4e-13 48.8 0.0 1.6e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 ORX68471.1 - 0.0088 16.4 10.7 0.0088 16.4 10.7 4.5 3 1 1 4 4 4 1 Ring finger domain Trans_reg_C PF00486.28 ORX68471.1 - 0.05 13.7 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal BAR_3_WASP_bdg PF10456.9 ORX68472.1 - 0.023 14.1 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein CENP-H PF05837.12 ORX68472.1 - 0.035 14.5 0.2 0.035 14.5 0.2 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HD_assoc PF13286.6 ORX68472.1 - 0.1 13.1 1.7 0.22 12.1 1.2 1.9 1 1 1 2 2 2 0 Phosphohydrolase-associated domain THOC7 PF05615.13 ORX68472.1 - 2 8.7 9.1 7.4 6.9 9.1 1.9 1 1 0 1 1 1 0 Tho complex subunit 7 FTA4 PF13093.6 ORX68473.1 - 0.75 9.7 10.8 0.24 11.3 2.2 2.6 1 1 1 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Bud13 PF09736.9 ORX68473.1 - 6 7.2 12.2 1.5 9.2 5.0 2.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex NAT PF04768.13 ORX68474.1 - 3.5e-39 134.2 0.0 6.2e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Acetyltransf_1 PF00583.25 ORX68474.1 - 0.15 12.3 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family RabGAP-TBC PF00566.18 ORX68475.1 - 1.6e-53 181.6 0.2 1e-52 178.9 0.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain HAV_VP PF12944.7 ORX68475.1 - 0.029 14.3 0.1 0.045 13.7 0.1 1.2 1 0 0 1 1 1 0 Hepatitis A virus viral protein VP ZapB PF06005.12 ORX68475.1 - 0.19 12.2 31.9 2 8.9 17.1 2.9 2 1 0 2 2 2 0 Cell division protein ZapB HisKA_4TM PF16926.5 ORX68475.1 - 0.2 11.2 0.0 0.51 9.9 0.1 1.6 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase BLOC1_2 PF10046.9 ORX68475.1 - 0.3 11.4 14.5 0.53 10.6 2.2 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SATase_N PF06426.14 ORX68475.1 - 0.42 11.0 6.8 0.46 10.9 3.3 2.7 2 1 1 3 3 3 0 Serine acetyltransferase, N-terminal FUSC PF04632.12 ORX68475.1 - 0.48 8.9 19.4 0.78 8.2 19.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 ORX68475.1 - 1.7 9.3 21.4 3.2 8.4 8.6 2.7 1 1 1 2 2 2 0 Initiation control protein YabA DUF4172 PF13776.6 ORX68475.1 - 1.8 9.0 4.3 0.58 10.5 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4172) Exonuc_VII_L PF02601.15 ORX68475.1 - 2 7.9 13.9 3.3 7.2 13.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Rootletin PF15035.6 ORX68475.1 - 2.1 8.3 31.1 9 6.3 16.4 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.12 ORX68475.1 - 2.4 8.2 5.3 6 6.9 5.0 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3450 PF11932.8 ORX68475.1 - 2.8 7.2 26.7 0.6 9.4 12.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Mod_r PF07200.13 ORX68475.1 - 3.1 7.9 24.5 4.7 7.3 10.1 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Tropomyosin_1 PF12718.7 ORX68475.1 - 3.6 7.7 31.1 1.7 8.8 3.2 2.2 1 1 1 2 2 2 0 Tropomyosin like Cnn_1N PF07989.11 ORX68475.1 - 4.8 7.4 21.9 1.5 9.0 2.6 2.9 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 Z1 PF10593.9 ORX68475.1 - 5 6.5 8.8 1.2 8.6 4.4 1.9 1 1 1 2 2 2 0 Z1 domain DUF724 PF05266.14 ORX68475.1 - 6.4 6.6 18.7 22 4.8 18.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fib_alpha PF08702.10 ORX68475.1 - 9.6 6.4 10.9 20 5.4 10.2 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family NYD-SP28_assoc PF14775.6 ORX68475.1 - 9.6 6.4 11.0 0.65 10.1 1.4 3.3 2 1 1 3 3 3 0 Sperm tail C-terminal domain Cu-oxidase_3 PF07732.15 ORX68478.1 - 2.4e-41 140.5 3.7 1.9e-34 118.2 0.5 4.4 4 0 0 4 4 4 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX68478.1 - 2.4e-35 121.3 7.5 4.7e-33 113.8 1.1 3.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX68478.1 - 3.3e-25 89.1 0.0 6.6e-23 81.6 0.0 3.1 3 0 0 3 3 3 1 Multicopper oxidase DUF899 PF05988.12 ORX68479.1 - 0.07 12.6 0.1 0.092 12.3 0.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) Keratin_2_head PF16208.5 ORX68479.1 - 0.21 11.7 22.8 0.28 11.3 22.8 1.1 1 0 0 1 1 1 0 Keratin type II head DUF4354 PF14263.6 ORX68482.1 - 0.075 12.9 1.8 1 9.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4354) Rep_fac-A_C PF08646.10 ORX68483.1 - 0.064 13.0 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain Ephrin_rec_like PF07699.13 ORX68483.1 - 0.2 11.5 1.7 0.39 10.5 1.7 1.4 1 0 0 1 1 1 0 Putative ephrin-receptor like tRNA_m1G_MT PF01746.21 ORX68484.1 - 3e-33 115.2 1.5 3e-33 115.2 1.5 1.5 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase CCDC71L PF15374.6 ORX68484.1 - 0.097 11.9 6.1 0.13 11.5 6.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L CLN3 PF02487.17 ORX68484.1 - 0.29 10.1 0.7 0.43 9.6 0.7 1.2 1 0 0 1 1 1 0 CLN3 protein Peptidase_S49_N PF08496.10 ORX68484.1 - 2.2 8.3 13.0 2.1 8.4 10.8 1.9 1 1 1 2 2 2 0 Peptidase family S49 N-terminal DUF2956 PF11169.8 ORX68484.1 - 7.4 6.8 12.1 23 5.3 12.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2956) PET117 PF15786.5 ORX68485.1 - 2.8e-12 46.7 2.4 2.7e-11 43.6 2.4 1.9 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF4220 PF13968.6 ORX68485.1 - 0.045 13.1 0.0 0.045 13.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) WD40 PF00400.32 ORX68486.1 - 4.9e-31 106.3 13.1 2.5e-06 28.1 0.7 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX68486.1 - 1.6e-07 31.5 0.9 0.25 11.7 0.0 4.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX68486.1 - 3.3e-05 22.8 5.2 0.2 10.3 0.3 4.3 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ORX68486.1 - 0.022 13.3 0.5 0.67 8.4 0.4 2.8 1 1 1 3 3 3 0 Cytochrome D1 heme domain LisH_TPL PF17814.1 ORX68486.1 - 0.068 12.9 0.3 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 LisH-like dimerisation domain WD40_like PF17005.5 ORX68486.1 - 0.17 11.2 0.0 34 3.6 0.0 3.2 2 1 0 3 3 3 0 WD40-like domain PQQ_3 PF13570.6 ORX68486.1 - 0.41 11.2 8.6 17 6.0 0.0 4.3 4 0 0 4 4 4 0 PQQ-like domain ArgJ PF01960.18 ORX68487.1 - 8.1e-143 475.7 4.6 9.3e-143 475.5 4.6 1.0 1 0 0 1 1 1 1 ArgJ family Y_phosphatase PF00102.27 ORX68488.1 - 5.6e-65 219.2 0.0 1.2e-64 218.1 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ORX68488.1 - 0.011 15.7 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family HpcH_HpaI PF03328.14 ORX68489.1 - 4.9e-14 52.0 0.2 5.9e-14 51.7 0.2 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family NIF PF03031.18 ORX68493.1 - 1.9e-20 73.2 0.0 3.2e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Castor_Poll_mid PF06241.12 ORX68493.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Castor and Pollux, part of voltage-gated ion channel zf-BED PF02892.15 ORX68494.1 - 0.00071 19.5 0.1 0.0015 18.5 0.1 1.6 1 0 0 1 1 1 1 BED zinc finger HpcH_HpaI PF03328.14 ORX68495.1 - 1.3e-36 125.8 0.0 1.7e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 ORX68495.1 - 0.051 12.5 0.0 0.069 12.0 0.0 1.1 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain PIG-X PF08320.12 ORX68496.1 - 4.1e-22 79.2 0.2 3e-21 76.3 0.1 2.2 2 1 0 2 2 2 1 PIG-X / PBN1 STE PF02200.16 ORX68497.1 - 2.1e-46 156.9 0.0 2.5e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 ORX68498.1 - 1.1e-14 53.9 8.1 1.2e-07 31.8 0.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX68498.1 - 4.6e-10 39.5 2.4 4.6e-10 39.5 2.4 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX68498.1 - 1e-09 38.4 6.9 0.00029 21.4 0.1 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger Sina PF03145.16 ORX68498.1 - 0.00018 21.5 2.1 0.00022 21.3 2.1 1.0 1 0 0 1 1 1 1 Seven in absentia protein family FOXP-CC PF16159.5 ORX68498.1 - 0.00063 20.3 0.9 1 10.1 0.1 2.0 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 ORX68498.1 - 0.0012 19.0 0.5 0.0019 18.3 0.5 1.4 1 1 0 1 1 1 1 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 ORX68498.1 - 0.0012 19.0 2.0 1.5 9.2 0.0 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ORX68498.1 - 0.0023 18.2 0.2 0.0046 17.2 0.2 1.5 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-TRAF PF02176.18 ORX68498.1 - 0.006 17.2 2.4 1.5 9.6 0.4 2.1 2 0 0 2 2 2 2 TRAF-type zinc finger zf-C2H2_6 PF13912.6 ORX68498.1 - 0.018 15.1 0.1 0.018 15.1 0.1 2.7 3 2 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 ORX68498.1 - 0.024 15.0 1.5 8 7.0 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type IBR PF01485.21 ORX68498.1 - 0.026 14.8 0.6 0.34 11.2 0.1 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain OrsD PF12013.8 ORX68498.1 - 0.027 14.9 2.1 1.2 9.6 0.1 2.0 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-LYAR PF08790.11 ORX68498.1 - 0.035 14.0 0.5 0.73 9.8 0.0 2.4 2 1 0 2 2 2 0 LYAR-type C2HC zinc finger zf-H2C2_5 PF13909.6 ORX68498.1 - 0.62 9.9 14.7 0.87 9.4 0.5 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Tcf25 PF04910.14 ORX68500.1 - 2.2e-90 303.3 0.2 3.2e-90 302.7 0.2 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 SLX9 PF15341.6 ORX68500.1 - 0.091 13.2 0.3 5.3 7.5 0.2 2.8 2 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 Cu-oxidase_3 PF07732.15 ORX68501.1 - 4.1e-41 139.7 3.0 3.2e-34 117.5 0.3 4.4 4 0 0 4 4 4 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX68501.1 - 2.1e-34 118.2 10.8 2.7e-33 114.6 0.9 3.3 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX68501.1 - 2.1e-25 89.7 0.0 1e-22 81.0 0.0 3.2 3 0 0 3 3 3 1 Multicopper oxidase DUF899 PF05988.12 ORX68501.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) DUF5320 PF17253.2 ORX68501.1 - 0.14 13.3 6.8 0.35 12.0 6.8 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) DUF5630 PF18632.1 ORX68501.1 - 0.2 10.9 3.5 0.31 10.3 3.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5630) RhoGAP PF00620.27 ORX68502.1 - 6.1e-43 146.3 0.0 1.1e-42 145.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX68502.1 - 3.3e-18 65.7 19.2 2e-10 40.7 6.8 3.1 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 ORX68502.1 - 4.1e-09 36.2 8.8 4.1e-09 36.2 8.8 3.5 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3330 PF11809.8 ORX68502.1 - 0.35 10.9 7.3 4.4 7.4 7.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3330) DUF2685 PF10886.8 ORX68502.1 - 7.4 6.8 12.5 2 8.7 0.3 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2685) TFIID_30kDa PF03540.13 ORX68503.1 - 4e-26 90.7 0.2 7e-26 89.9 0.2 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 ORX68503.1 - 0.024 14.7 0.1 6.8 6.8 0.0 2.2 1 1 1 2 2 2 0 Bromodomain associated TAF PF02969.17 ORX68503.1 - 0.064 13.4 0.9 0.12 12.6 0.4 1.7 1 1 1 2 2 2 0 TATA box binding protein associated factor (TAF) Slx4 PF09494.10 ORX68503.1 - 0.12 12.4 0.0 2.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Slx4 endonuclease CwfJ_C_1 PF04677.15 ORX68506.1 - 3.7e-23 81.7 0.0 7.8e-23 80.7 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 ORX68506.1 - 8.5e-10 38.3 3.9 2e-09 37.1 3.9 1.7 1 0 0 1 1 1 1 Zinc knuckle CwfJ_C_2 PF04676.14 ORX68506.1 - 5.4e-08 33.6 0.0 2.5e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 eIF3g PF12353.8 ORX68506.1 - 0.0014 19.1 0.1 0.0024 18.2 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Cwf_Cwc_15 PF04889.12 ORX68507.1 - 0.24 11.1 9.8 0.28 10.9 9.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ORX68507.1 - 0.31 11.5 10.1 0.4 11.1 10.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TFIIF_alpha PF05793.12 ORX68507.1 - 1.9 7.0 8.5 2 6.9 8.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ORX68507.1 - 7.5 4.5 6.9 6.7 4.7 6.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi Zip PF02535.22 ORX68508.1 - 2.9e-54 184.5 12.9 2.9e-54 184.5 12.9 1.6 2 0 0 2 2 2 1 ZIP Zinc transporter MRC1 PF09444.10 ORX68509.1 - 1.4e-15 58.1 21.8 1.4e-15 58.1 21.8 7.0 5 1 1 6 6 6 1 MRC1-like domain YceD PF02620.17 ORX68509.1 - 0.93 9.6 8.3 0.086 13.0 1.1 3.1 2 0 0 2 2 2 0 Large ribosomal RNA subunit accumulation protein YceD Ran-binding PF05508.11 ORX68511.1 - 2.1e-61 207.7 0.9 2.7e-29 102.2 1.6 2.9 1 1 1 2 2 2 2 RanGTP-binding protein Eaf7 PF07904.13 ORX68511.1 - 0.12 12.7 0.5 0.39 11.1 0.2 1.9 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 TPR_2 PF07719.17 ORX68512.1 - 2e-08 33.7 16.3 0.079 13.1 1.0 7.7 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX68512.1 - 1.4e-06 27.9 7.9 0.19 11.6 0.3 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX68512.1 - 5.4e-06 26.8 21.1 0.24 12.3 1.0 8.1 3 2 5 8 8 8 3 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 ORX68512.1 - 0.00056 20.2 0.0 0.072 13.4 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain ANAPC3 PF12895.7 ORX68512.1 - 0.0015 18.7 11.1 2.6 8.3 0.4 5.6 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ORX68512.1 - 0.0016 18.7 16.6 0.0025 18.1 0.1 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX68512.1 - 0.0019 18.2 9.9 3.2 8.2 0.0 6.7 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX68512.1 - 0.0045 17.5 29.3 0.23 12.0 0.2 7.3 4 2 5 9 9 9 4 Tetratricopeptide repeat PPR PF01535.20 ORX68512.1 - 0.023 14.9 0.8 5.8 7.4 0.0 3.8 3 0 0 3 3 3 0 PPR repeat TPR_11 PF13414.6 ORX68512.1 - 0.11 12.2 11.6 18 5.1 0.0 6.0 7 0 0 7 7 7 0 TPR repeat TPR_21 PF09976.9 ORX68512.1 - 0.2 11.3 9.9 6.2 6.5 1.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 ORX68512.1 - 1.3 9.8 6.7 1.1e+02 3.8 0.0 5.8 5 1 0 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.6 ORX68512.1 - 2.4 7.5 8.7 0.28 10.6 2.9 2.2 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP Fungal_trans PF04082.18 ORX68516.1 - 2.2e-21 76.1 0.0 3.6e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX68516.1 - 3.1e-08 33.6 12.7 6.6e-08 32.5 12.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1192 PF06698.11 ORX68517.1 - 0.065 13.3 0.6 0.72 9.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF3734 PF12536.8 ORX68517.1 - 0.21 11.9 0.0 0.21 11.9 0.0 3.0 4 0 0 4 4 4 0 Patatin phospholipase Fungal_trans PF04082.18 ORX68518.1 - 1.6e-22 79.8 0.1 3.5e-22 78.7 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX68518.1 - 1.8e-09 37.5 14.3 3.3e-09 36.7 14.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YL1 PF05764.13 ORX68518.1 - 0.62 10.1 10.3 1.1 9.4 10.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 ORX68518.1 - 2.7 7.7 18.8 4.8 6.8 18.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ORX68518.1 - 3.8 5.7 12.4 5.3 5.2 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ORX68518.1 - 4.5 6.6 15.1 7.1 6.0 15.1 1.3 1 0 0 1 1 1 0 SDA1 DUF908 PF06012.12 ORX68521.1 - 1.5e-14 54.2 5.5 2.7e-14 53.3 5.5 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) UBM PF14377.6 ORX68522.1 - 4.3e-15 54.6 18.9 2.8e-08 32.9 1.4 3.6 3 0 0 3 3 3 2 Ubiquitin binding region TAF4 PF05236.14 ORX68522.1 - 3.9 7.1 17.5 1.3 8.7 7.8 2.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Hydin_ADK PF17213.3 ORX68522.1 - 5.1 7.3 9.8 0.37 11.0 2.7 2.7 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Borrelia_P83 PF05262.11 ORX68522.1 - 9.6 4.6 9.2 16 3.9 9.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein HECT PF00632.25 ORX68523.1 - 3.5e-97 325.6 0.0 3.9e-97 325.5 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Cid2 PF09774.9 ORX68524.1 - 4.2e-18 66.3 6.3 8e-16 58.9 6.3 2.3 1 1 0 1 1 1 1 Caffeine-induced death protein 2 HTH_20 PF12840.7 ORX68524.1 - 0.017 15.2 1.2 0.32 11.1 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain KicB PF03882.14 ORX68524.1 - 0.09 13.0 2.0 0.49 10.6 0.2 2.1 1 1 1 2 2 2 0 MukF winged-helix domain CBS PF00571.28 ORX68525.1 - 1.1e-15 57.8 0.8 0.0034 17.8 0.0 4.4 4 0 0 4 4 4 4 CBS domain TC1 PF15063.6 ORX68525.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Thyroid cancer protein 1 RRM_1 PF00076.22 ORX68526.1 - 0.087 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ PF00226.31 ORX68527.1 - 2.8e-21 75.4 0.0 5.5e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.9 ORX68527.1 - 0.0018 18.0 0.2 0.0018 18.0 0.2 1.7 1 1 1 2 2 2 1 Transmembrane Fragile-X-F protein Fungal_trans PF04082.18 ORX68528.1 - 3.9e-06 26.1 0.0 7.4e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX68529.1 - 1.6e-12 47.3 14.1 1.9e-12 47.1 14.1 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 ORX68529.1 - 0.03 14.7 5.0 0.08 13.3 2.1 2.2 2 0 0 2 2 2 0 Opy2 protein Fungal_trans PF04082.18 ORX68530.1 - 6.5e-07 28.7 0.3 1.1e-06 27.9 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 ORX68531.1 - 1.9e-18 66.5 52.6 1.4e-08 34.1 10.4 3.9 1 1 3 4 4 4 4 Major Facilitator Superfamily FYVE PF01363.21 ORX68533.1 - 3.4e-20 71.9 29.4 1e-14 54.4 6.1 2.6 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 ORX68533.1 - 8.3e-09 35.0 0.8 1.6e-08 34.2 0.8 1.5 1 0 0 1 1 1 1 Rabenosyn Rab binding domain HypA PF01155.19 ORX68533.1 - 0.29 11.2 13.4 1.6 8.8 4.3 3.5 3 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 ORX68533.1 - 0.47 10.0 3.1 11 5.6 0.1 2.9 2 0 0 2 2 2 0 C2H2 type zinc-finger UBZ_FAAP20 PF15750.5 ORX68533.1 - 2.5 8.1 6.3 1.1 9.3 0.3 3.0 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-met PF12874.7 ORX68533.1 - 5.2 7.6 9.6 28 5.3 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type TB2_DP1_HVA22 PF03134.19 ORX68534.1 - 2.9e-28 97.6 1.7 4e-28 97.1 1.7 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family RabGAP-TBC PF00566.18 ORX68535.1 - 2.2e-52 177.8 0.0 2.6e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain BRE1 PF08647.11 ORX68536.1 - 7.6e-10 38.7 12.1 7.6e-10 38.7 12.1 8.8 5 4 3 8 8 8 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 ORX68536.1 - 7.2e-08 32.2 9.5 1.5e-07 31.2 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX68536.1 - 9.5e-07 28.6 13.6 2.1e-06 27.5 13.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX68536.1 - 1.5e-05 24.7 13.4 3.3e-05 23.6 13.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX68536.1 - 5.2e-05 23.2 10.2 0.00014 21.8 10.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX68536.1 - 7.3e-05 23.0 12.9 0.00016 21.9 12.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ORX68536.1 - 0.00014 21.7 13.1 0.00033 20.6 13.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ORX68536.1 - 0.00034 20.7 9.8 0.00081 19.5 9.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ORX68536.1 - 0.0012 18.6 11.1 0.0033 17.3 10.6 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ORX68536.1 - 0.014 15.7 10.0 0.052 13.8 10.0 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 ORX68536.1 - 0.017 14.9 4.7 0.044 13.7 4.7 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ORX68536.1 - 0.24 11.2 9.5 0.1 12.4 2.7 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ORX68536.1 - 0.38 10.8 4.1 0.96 9.5 4.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Toprim PF01751.22 ORX68536.1 - 0.4 10.9 1.6 1.5 9.1 0.6 2.6 2 1 0 2 2 2 0 Toprim domain zinc-ribbons_6 PF07191.12 ORX68536.1 - 0.46 10.5 7.6 1.6 8.8 7.6 2.0 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 ORX68536.1 - 0.76 9.9 6.3 2.3 8.3 6.3 1.8 1 0 0 1 1 1 0 Double zinc ribbon MtrG PF04210.13 ORX68536.1 - 1.6 8.6 3.1 1.3 8.9 0.4 2.4 2 0 0 2 2 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G zf-Nse PF11789.8 ORX68536.1 - 1.8 8.5 9.2 4.9 7.1 9.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF4379 PF14311.6 ORX68536.1 - 5.8 7.4 7.7 1.6 9.1 1.7 2.7 2 0 0 2 2 2 0 Probable Zinc-ribbon domain NAP PF00956.18 ORX68538.1 - 1.1e-84 283.8 5.4 1.1e-84 283.8 5.4 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) CCDC92 PF14916.6 ORX68538.1 - 0.00026 20.7 0.2 0.00067 19.4 0.2 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Cwf_Cwc_15 PF04889.12 ORX68538.1 - 0.007 16.1 14.8 0.007 16.1 14.8 2.1 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 ORX68538.1 - 4.8 6.4 21.7 0.63 9.3 14.5 2.1 2 0 0 2 2 2 0 BUD22 MMR_HSR1 PF01926.23 ORX68539.1 - 8.6e-22 77.4 0.2 1.8e-21 76.4 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX68539.1 - 7.7e-11 42.2 4.0 2.2e-05 24.4 0.1 2.6 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX68539.1 - 1.5e-10 40.8 0.1 2.2e-10 40.3 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ORX68539.1 - 2.3e-06 27.3 5.2 3.4e-05 23.5 0.3 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX68539.1 - 7.4e-06 26.1 7.9 0.00026 21.1 0.2 3.2 2 1 1 3 3 3 1 Dynamin family ATP_bind_1 PF03029.17 ORX68539.1 - 7.6e-06 25.9 1.5 0.00076 19.3 0.0 2.5 3 0 0 3 3 2 1 Conserved hypothetical ATP binding protein cobW PF02492.19 ORX68539.1 - 1.6e-05 24.6 0.6 0.0013 18.3 0.1 2.4 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.16 ORX68539.1 - 2.5e-05 23.7 0.1 2.5e-05 23.7 0.1 2.0 2 0 0 2 2 1 1 AIG1 family Roc PF08477.13 ORX68539.1 - 5.6e-05 23.3 2.9 0.00021 21.5 0.1 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX68539.1 - 0.00013 21.6 0.1 0.00074 19.1 0.1 2.0 1 1 0 1 1 1 1 Ras family PduV-EutP PF10662.9 ORX68539.1 - 0.00019 21.2 0.1 0.00083 19.1 0.1 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ORX68539.1 - 0.00024 20.6 0.1 0.00053 19.5 0.1 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Ribosomal_S2 PF00318.20 ORX68539.1 - 0.004 16.4 1.0 0.0081 15.4 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S2 SRPRB PF09439.10 ORX68539.1 - 0.0053 16.2 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 ORX68539.1 - 0.016 15.2 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DDE_Tnp_ISL3 PF01610.17 ORX68539.1 - 0.022 14.5 1.2 0.036 13.8 1.2 1.3 1 0 0 1 1 1 0 Transposase AAA_28 PF13521.6 ORX68539.1 - 0.026 14.8 0.1 0.026 14.8 0.1 2.8 2 1 1 3 3 3 0 AAA domain Host_attach PF10116.9 ORX68539.1 - 0.056 14.0 3.6 0.18 12.4 3.3 1.8 2 0 0 2 2 2 0 Protein required for attachment to host cells AAA_29 PF13555.6 ORX68539.1 - 0.066 13.0 0.1 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain KH_2 PF07650.17 ORX68539.1 - 0.075 12.9 0.3 0.2 11.5 0.3 1.7 1 0 0 1 1 1 0 KH domain G-alpha PF00503.20 ORX68539.1 - 0.078 12.1 3.6 2.8 7.0 0.0 2.7 2 1 1 3 3 3 0 G-protein alpha subunit RHD3 PF05879.12 ORX68539.1 - 0.11 10.6 0.0 0.11 10.6 0.0 2.8 3 0 0 3 3 3 0 Root hair defective 3 GTP-binding protein (RHD3) AAA_22 PF13401.6 ORX68539.1 - 0.28 11.5 1.7 0.34 11.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain TFIIA PF03153.13 ORX68539.1 - 0.3 11.0 14.8 0.39 10.7 14.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 ORX68539.1 - 1.4 7.6 4.1 1.9 7.2 4.1 1.1 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 ORX68539.1 - 1.6 8.7 7.9 2.3 8.1 7.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 ORX68539.1 - 1.7 8.6 4.1 2.7 8.0 4.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_23 PF13476.6 ORX68539.1 - 1.8 9.1 9.9 3.9 7.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX68539.1 - 1.9 9.0 5.8 0.78 10.3 0.2 2.5 2 1 0 2 2 2 0 ABC transporter Androgen_recep PF02166.16 ORX68539.1 - 5.7 5.7 15.5 7.9 5.2 15.5 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 ORX68539.1 - 8.7 5.9 17.9 13 5.3 17.9 1.2 1 0 0 1 1 1 0 Spt20 family Cwf_Cwc_15 PF04889.12 ORX68540.1 - 0.061 13.0 4.7 0.099 12.4 4.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ORX68540.1 - 0.73 9.1 9.9 1.1 8.5 9.9 1.2 1 0 0 1 1 1 0 NOA36 protein Peptidase_S10 PF00450.22 ORX68541.1 - 2.5e-116 389.6 0.1 3e-116 389.3 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DDE_Tnp_4 PF13359.6 ORX68545.1 - 0.0013 18.4 0.0 0.0042 16.8 0.0 1.7 1 1 1 2 2 2 1 DDE superfamily endonuclease Cu-oxidase PF00394.22 ORX68546.1 - 0.13 12.4 0.2 0.59 10.2 0.1 2.0 1 1 1 2 2 2 0 Multicopper oxidase AAA PF00004.29 ORX68547.1 - 4.8e-55 185.6 0.0 4.8e-42 143.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 ORX68547.1 - 3.4e-19 69.0 0.4 7.3e-19 68.0 0.4 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 ORX68547.1 - 2e-14 53.1 0.1 2.3e-09 36.9 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX68547.1 - 1.2e-11 45.2 10.8 0.00047 20.6 0.1 4.7 3 2 2 5 5 4 2 AAA ATPase domain NACHT PF05729.12 ORX68547.1 - 4.4e-09 36.5 0.1 3.1e-05 24.0 0.0 3.1 3 0 0 3 3 2 2 NACHT domain AAA_22 PF13401.6 ORX68547.1 - 7.2e-09 36.0 4.5 0.00015 22.1 0.8 4.3 3 2 1 4 4 4 2 AAA domain AAA_25 PF13481.6 ORX68547.1 - 3e-08 33.5 2.4 0.043 13.4 0.0 4.3 2 2 2 4 4 4 2 AAA domain PEX-2N PF09263.10 ORX68547.1 - 1.8e-07 31.4 0.0 4.2e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal IstB_IS21 PF01695.17 ORX68547.1 - 6.9e-07 29.2 0.0 0.015 15.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 ORX68547.1 - 1.9e-06 28.4 0.0 0.067 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ORX68547.1 - 3.4e-06 27.3 0.0 0.28 11.3 0.0 4.0 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 ORX68547.1 - 9.2e-06 25.7 0.0 0.0092 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ORX68547.1 - 2e-05 24.9 0.0 0.28 11.6 0.0 2.7 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.12 ORX68547.1 - 2.9e-05 23.9 0.0 0.00019 21.2 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 ORX68547.1 - 5.8e-05 22.4 0.3 0.11 11.6 0.2 2.8 2 1 0 2 2 2 2 NB-ARC domain TIP49 PF06068.13 ORX68547.1 - 0.00027 20.3 0.1 0.017 14.3 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain DUF2075 PF09848.9 ORX68547.1 - 0.00047 19.5 0.1 2.4 7.3 0.0 3.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 ORX68547.1 - 0.00048 19.4 0.0 0.021 14.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 ORX68547.1 - 0.00053 20.0 0.3 0.38 10.7 0.0 3.5 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 ORX68547.1 - 0.0007 19.4 0.0 1.4 8.6 0.0 2.7 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 ORX68547.1 - 0.0009 19.8 0.0 1.1 9.8 0.0 3.0 2 0 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 ORX68547.1 - 0.0012 19.3 0.1 0.092 13.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ORX68547.1 - 0.0013 18.7 0.0 0.42 10.6 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 ORX68547.1 - 0.0013 19.0 0.2 3.5 7.9 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 ORX68547.1 - 0.0021 17.6 0.0 0.57 9.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region ATP-synt_ab PF00006.25 ORX68547.1 - 0.0023 17.6 0.0 0.016 14.9 0.0 2.2 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_2 PF07724.14 ORX68547.1 - 0.0023 18.1 0.0 0.53 10.4 0.0 3.4 4 0 0 4 4 3 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 ORX68547.1 - 0.0031 17.2 0.0 3.1 7.5 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 ORX68547.1 - 0.0059 16.0 0.4 0.82 9.0 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ORX68547.1 - 0.0061 16.5 0.0 0.67 9.8 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 ORX68547.1 - 0.014 14.6 0.0 4.4 6.5 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ORX68547.1 - 0.018 14.8 0.1 0.84 9.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain Bac_DnaA PF00308.18 ORX68547.1 - 0.02 14.8 0.0 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein ATPase PF06745.13 ORX68547.1 - 0.025 13.9 1.2 3.5 6.9 0.0 3.3 3 1 1 4 4 3 0 KaiC PhoH PF02562.16 ORX68547.1 - 0.037 13.5 0.0 7.9 5.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 ORX68547.1 - 0.039 14.3 0.0 1.7 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ORX68547.1 - 0.041 13.6 0.1 1.1 9.0 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ORX68547.1 - 0.045 13.5 0.0 8.5 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ORX68547.1 - 0.046 13.8 0.0 4.6 7.4 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.20 ORX68547.1 - 0.054 12.7 0.3 0.2 10.8 0.0 2.1 3 0 0 3 3 2 0 G-protein alpha subunit DnaB_C PF03796.15 ORX68547.1 - 0.066 12.5 0.0 4.1 6.7 0.0 2.4 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain SRP54 PF00448.22 ORX68547.1 - 0.077 12.6 0.0 0.36 10.4 0.0 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_3 PF07726.11 ORX68547.1 - 0.093 12.6 0.0 1.7 8.5 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 ORX68547.1 - 0.11 12.7 0.0 0.74 10.0 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SKI PF01202.22 ORX68547.1 - 0.13 12.4 0.0 5.7 7.1 0.0 3.0 2 0 0 2 2 2 0 Shikimate kinase PAS_8 PF13188.7 ORX68547.1 - 0.14 12.2 0.0 0.55 10.3 0.0 2.0 1 0 0 1 1 1 0 PAS domain Cytidylate_kin2 PF13189.6 ORX68547.1 - 0.14 12.3 0.0 0.73 9.9 0.0 2.2 3 0 0 3 3 1 0 Cytidylate kinase-like family Rad17 PF03215.15 ORX68547.1 - 0.15 12.0 0.0 14 5.5 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain DUF2937 PF11157.8 ORX68547.1 - 0.36 10.5 3.1 0.24 11.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Ribosomal_L32p PF01783.23 ORX68548.1 - 7.4e-11 42.1 6.6 7.9e-11 42.1 6.6 1.0 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-RING_4 PF14570.6 ORX68548.1 - 0.017 14.9 2.1 0.033 14.0 2.1 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Tim44 PF04280.15 ORX68549.1 - 3.4e-15 56.4 0.0 4.9e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 ORX68549.1 - 7.6e-05 21.9 0.0 0.0001 21.5 0.0 1.2 1 0 0 1 1 1 1 MBA1-like protein BSD PF03909.17 ORX68550.1 - 7.6e-20 70.7 0.2 3.3e-12 46.2 0.0 3.0 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 ORX68550.1 - 1.9e-14 53.7 0.0 9.9e-14 51.4 0.0 2.1 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain BPL_N PF09825.9 ORX68550.1 - 0.01 14.9 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal TPPII_N PF12583.8 ORX68551.1 - 0.69 10.5 0.1 0.69 10.5 0.1 3.4 3 1 1 4 4 4 0 Tripeptidyl peptidase II N terminal CTP_transf_like PF01467.26 ORX68552.1 - 8.1e-31 107.1 0.0 1.1e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like HP1451_C PF18472.1 ORX68552.1 - 0.018 15.0 0.4 5.4 7.1 0.4 3.0 3 0 0 3 3 3 0 HP1451 C-terminal domain DUF5639 PF18690.1 ORX68552.1 - 0.026 14.7 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5639) Amidase_2 PF01510.25 ORX68554.1 - 0.59 10.6 5.7 1.3 9.5 5.2 1.9 2 0 0 2 2 2 0 N-acetylmuramoyl-L-alanine amidase DUF3128 PF11326.8 ORX68555.1 - 5e-22 78.1 3.0 5.8e-22 77.8 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) COPIIcoated_ERV PF07970.12 ORX68556.1 - 2.9e-34 118.9 0.3 4.1e-34 118.4 0.3 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ORX68556.1 - 6.8e-26 90.4 1.0 1.1e-25 89.8 0.1 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) BolA PF01722.18 ORX68557.1 - 1.7e-09 37.8 0.0 4.8e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein WD40 PF00400.32 ORX68558.1 - 1.9e-22 79.1 9.6 0.001 19.8 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX68558.1 - 1e-09 38.6 0.3 0.027 14.8 0.0 5.2 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX68558.1 - 6.9e-09 34.9 4.0 0.034 12.8 0.2 4.0 2 1 2 4 4 4 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ORX68558.1 - 3.6e-06 26.7 0.8 0.081 12.5 0.1 2.7 1 1 2 3 3 3 2 PQQ-like domain Cytochrom_D1 PF02239.16 ORX68558.1 - 0.00097 17.8 0.3 0.84 8.1 0.0 3.5 1 1 3 4 4 4 2 Cytochrome D1 heme domain WD40_like PF17005.5 ORX68558.1 - 0.0025 17.2 0.0 0.0078 15.6 0.0 1.8 1 1 0 1 1 1 1 WD40-like domain PALB2_WD40 PF16756.5 ORX68558.1 - 0.0088 15.0 0.1 18 4.1 0.0 3.6 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain VID27 PF08553.10 ORX68558.1 - 0.059 12.4 0.0 0.13 11.2 0.0 1.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain ATG16 PF08614.11 ORX68559.1 - 3.1e-38 132.0 27.5 3.6e-38 131.8 27.5 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) HAP1_N PF04849.13 ORX68559.1 - 6e-05 22.4 26.1 0.0042 16.4 25.3 2.7 1 1 1 2 2 2 1 HAP1 N-terminal conserved region GAS PF13851.6 ORX68559.1 - 0.00034 20.0 26.0 0.0014 18.0 19.6 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 ORX68559.1 - 0.0014 19.0 15.2 0.0014 19.0 15.2 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.8 ORX68559.1 - 0.0016 18.4 7.6 0.0016 18.4 7.6 3.6 2 1 2 4 4 4 1 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 ORX68559.1 - 0.0035 17.1 18.3 0.43 10.4 0.0 4.4 3 2 1 4 4 4 2 Septum formation initiator CALCOCO1 PF07888.11 ORX68559.1 - 0.012 14.5 24.8 0.015 14.2 24.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like L31 PF09784.9 ORX68559.1 - 0.012 16.0 3.7 3 8.3 0.1 2.6 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 GrpE PF01025.19 ORX68559.1 - 0.014 15.1 2.3 0.014 15.1 2.3 2.9 1 1 1 2 2 2 0 GrpE YabA PF06156.13 ORX68559.1 - 0.016 15.9 3.7 0.016 15.9 3.7 3.3 1 1 2 3 3 3 0 Initiation control protein YabA Shugoshin_N PF07558.11 ORX68559.1 - 0.025 14.4 9.0 0.28 11.1 0.6 3.6 3 1 0 3 3 3 0 Shugoshin N-terminal coiled-coil region UPF0242 PF06785.11 ORX68559.1 - 0.045 13.9 23.4 0.23 11.6 12.8 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 ORX68559.1 - 0.097 12.9 30.4 0.081 13.1 2.9 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Rootletin PF15035.6 ORX68559.1 - 0.1 12.6 24.1 0.14 12.2 11.8 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion AAA_27 PF13514.6 ORX68559.1 - 0.11 12.1 6.1 0.044 13.4 1.5 2.3 1 1 0 2 2 2 0 AAA domain KLRAQ PF10205.9 ORX68559.1 - 0.14 12.4 18.5 0.038 14.2 10.7 3.0 2 2 1 3 3 2 0 Predicted coiled-coil domain-containing protein Ax_dynein_light PF10211.9 ORX68559.1 - 0.29 11.1 26.3 0.23 11.4 10.6 3.2 2 1 1 3 3 3 0 Axonemal dynein light chain CcdA PF07362.12 ORX68559.1 - 0.32 11.5 5.3 0.66 10.4 0.0 3.0 2 1 1 3 3 2 0 Post-segregation antitoxin CcdA bZIP_1 PF00170.21 ORX68559.1 - 0.35 11.0 22.1 1.1 9.4 1.0 4.5 2 1 2 5 5 5 0 bZIP transcription factor DUF4407 PF14362.6 ORX68559.1 - 0.36 10.1 15.6 0.54 9.5 15.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec34 PF04136.15 ORX68559.1 - 0.41 10.5 14.7 3 7.7 4.6 3.3 2 1 1 3 3 3 0 Sec34-like family Fez1 PF06818.15 ORX68559.1 - 0.41 11.1 21.8 0.18 12.2 13.3 2.2 1 1 1 2 2 2 0 Fez1 DUF948 PF06103.11 ORX68559.1 - 0.5 10.6 16.0 0.55 10.5 2.9 4.1 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 ORX68559.1 - 0.54 10.5 29.6 1.6 8.9 0.3 3.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Bacillus_HBL PF05791.11 ORX68559.1 - 0.63 9.8 8.0 0.53 10.1 5.1 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 ORX68559.1 - 0.66 8.8 25.5 0.27 10.1 22.3 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein ZapB PF06005.12 ORX68559.1 - 0.71 10.3 34.1 0.56 10.7 3.5 4.3 3 1 1 4 4 4 0 Cell division protein ZapB AAA_13 PF13166.6 ORX68559.1 - 0.83 8.2 12.7 0.91 8.1 11.7 1.7 1 1 0 1 1 1 0 AAA domain HOOK PF05622.12 ORX68559.1 - 0.96 7.5 26.5 0.42 8.7 14.8 2.2 1 1 0 2 2 2 0 HOOK protein Lebercilin PF15619.6 ORX68559.1 - 1 9.0 30.2 0.32 10.6 25.0 2.4 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.8 ORX68559.1 - 1 9.4 27.9 1.6 8.8 9.3 3.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 ORX68559.1 - 1 9.9 30.1 4.9 7.7 15.7 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region Spore_III_AB PF09548.10 ORX68559.1 - 1.1 9.3 8.9 1.4 9.0 0.6 2.5 1 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) ING PF12998.7 ORX68559.1 - 1.2 9.8 11.1 0.17 12.5 1.8 2.9 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding CENP-H PF05837.12 ORX68559.1 - 1.2 9.6 28.3 0.55 10.7 4.3 3.1 1 1 1 3 3 3 0 Centromere protein H (CENP-H) DUF4349 PF14257.6 ORX68559.1 - 1.5 8.2 20.2 0.042 13.3 2.6 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4349) Fib_alpha PF08702.10 ORX68559.1 - 1.6 8.9 17.1 0.33 11.1 10.1 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Rx_N PF18052.1 ORX68559.1 - 1.7 9.0 11.0 13 6.2 11.0 2.5 1 1 0 1 1 1 0 Rx N-terminal domain HALZ PF02183.18 ORX68559.1 - 2.3 8.5 12.0 7.3 6.9 0.2 4.0 3 1 0 3 3 3 0 Homeobox associated leucine zipper HAUS-augmin3 PF14932.6 ORX68559.1 - 3.3 7.2 23.5 0.82 9.2 12.3 2.8 1 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 BLOC1_2 PF10046.9 ORX68559.1 - 3.4 8.0 18.7 0.48 10.8 5.0 3.9 2 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BRE1 PF08647.11 ORX68559.1 - 3.5 7.8 25.0 1.6 8.9 7.7 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF724 PF05266.14 ORX68559.1 - 3.7 7.3 17.2 23 4.7 15.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) SKA2 PF16740.5 ORX68559.1 - 4.2 7.2 19.8 0.42 10.4 2.4 3.0 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 TLE_N PF03920.15 ORX68559.1 - 4.3 7.4 10.8 2.5 8.2 2.1 2.9 1 1 2 3 3 3 0 Groucho/TLE N-terminal Q-rich domain Syntaxin-6_N PF09177.11 ORX68559.1 - 4.4 7.9 16.4 11 6.7 7.4 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Golgin_A5 PF09787.9 ORX68559.1 - 5.2 6.4 23.2 7.1 6.0 23.0 1.3 1 1 0 1 1 1 0 Golgin subfamily A member 5 FlaC_arch PF05377.11 ORX68559.1 - 6.7 7.2 14.8 17 5.9 2.5 4.8 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 ORX68559.1 - 7.1 6.9 25.7 0.95 9.7 4.4 3.8 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 FlxA PF14282.6 ORX68559.1 - 7.3 6.7 14.8 1.6 8.7 8.9 2.4 1 1 1 2 2 2 0 FlxA-like protein HIP1_clath_bdg PF16515.5 ORX68559.1 - 7.5 7.2 22.2 44 4.8 1.7 3.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CSN5_C PF18323.1 ORX68559.1 - 7.6 7.5 9.5 7.5 7.5 6.1 2.7 1 1 1 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain GIT_CC PF16559.5 ORX68559.1 - 8.1 6.4 13.8 0.34 10.8 1.2 3.6 3 2 2 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor SlyX PF04102.12 ORX68559.1 - 8.2 7.1 23.2 1.2 9.8 3.1 4.2 2 2 2 4 4 4 0 SlyX Cep57_CLD_2 PF14197.6 ORX68559.1 - 9 6.5 30.2 0.05 13.7 2.2 4.0 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 Laminin_II PF06009.12 ORX68559.1 - 9.3 6.3 18.5 0.54 10.3 2.5 3.2 2 1 1 3 3 3 0 Laminin Domain II Ras PF00071.22 ORX68560.1 - 2.5e-40 137.7 0.1 5.3e-39 133.4 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ORX68560.1 - 8.5e-24 84.1 0.0 1.6e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX68560.1 - 2.1e-05 24.1 0.0 0.0002 20.9 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX68560.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX68560.1 - 0.017 15.0 0.0 0.078 12.9 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 ORX68560.1 - 0.023 14.6 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ORX68560.1 - 0.032 14.0 0.0 0.032 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ORX68560.1 - 0.044 13.1 0.2 1.6 8.0 0.0 2.4 3 0 0 3 3 3 0 Septin AAA_16 PF13191.6 ORX68560.1 - 0.044 14.2 0.1 0.15 12.5 0.0 1.6 1 1 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 ORX68560.1 - 0.046 13.5 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 ORX68560.1 - 0.11 12.4 0.1 0.22 11.4 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 ORX68560.1 - 0.14 11.9 0.2 17 5.1 0.1 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ORX68560.1 - 0.17 12.1 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 ORX68560.1 - 0.2 11.1 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 ORX68560.1 - 0.2 10.8 0.1 0.84 8.7 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit ubiquitin PF00240.23 ORX68561.1 - 1.7e-10 40.5 0.0 1.9e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX68561.1 - 6.2e-05 22.7 0.0 7.3e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Blt1 PF12754.7 ORX68561.1 - 0.062 13.6 0.0 0.066 13.5 0.0 1.1 1 0 0 1 1 1 0 Blt1 N-terminal domain Ubiquitin_2 PF14560.6 ORX68561.1 - 0.068 13.6 0.2 0.14 12.6 0.2 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX68561.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 ORX68562.1 - 0.0004 20.2 6.3 0.0004 20.2 6.3 2.3 1 1 1 2 2 2 1 STI1 domain Com_YlbF PF06133.11 ORX68562.1 - 0.013 16.1 0.4 0.024 15.2 0.4 1.5 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA BSD PF03909.17 ORX68562.1 - 0.095 12.7 0.5 0.33 11.0 0.4 2.1 1 1 0 1 1 1 0 BSD domain XPC-binding PF09280.11 ORX68562.1 - 0.15 11.9 11.8 1.3e+02 2.4 11.7 3.2 1 1 0 1 1 1 0 XPC-binding domain PriC PF07445.12 ORX68562.1 - 0.32 10.9 2.6 2.4 8.0 0.8 2.0 2 0 0 2 2 2 0 Primosomal replication protein priC UBA PF00627.31 ORX68563.1 - 5.6e-05 23.0 0.1 8.8e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain HOIP-UBA PF16678.5 ORX68563.1 - 0.0027 17.7 0.0 0.0031 17.5 0.0 1.1 1 0 0 1 1 1 1 HOIP UBA domain pair HemN_C PF06969.16 ORX68563.1 - 0.063 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 HemN C-terminal domain NDUFA12 PF05071.16 ORX68564.1 - 7.2e-14 52.4 5.6 1.3e-09 38.7 5.6 2.2 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 EamA PF00892.20 ORX68565.1 - 2.7e-11 43.8 33.2 0.00011 22.4 19.1 3.1 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 ORX68565.1 - 0.00026 20.3 2.0 0.0024 17.2 0.3 2.3 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport DUF347 PF03988.12 ORX68565.1 - 0.75 10.0 12.6 2.8 8.2 6.4 4.1 2 1 0 2 2 2 0 Repeat of Unknown Function (DUF347) DOT1 PF08123.13 ORX68566.1 - 4.6e-70 235.3 0.0 5.8e-70 235.0 0.0 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 ORX68566.1 - 0.00038 21.1 0.0 0.00094 19.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX68566.1 - 0.00048 19.9 0.0 0.00082 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX68566.1 - 0.0011 18.8 0.0 0.0016 18.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX68566.1 - 0.0012 19.5 0.0 0.0033 18.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Prenyltrans PF00432.21 ORX68567.1 - 4.8e-16 58.2 13.4 4.8e-09 35.8 0.6 5.9 6 0 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat Glyco_hydro_18 PF00704.28 ORX68568.1 - 1.5e-81 274.6 0.0 1.7e-81 274.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 4F5 PF04419.14 ORX68569.1 - 9.9e-12 45.5 7.1 9.9e-12 45.5 7.1 1.8 2 0 0 2 2 2 1 4F5 protein family SMN PF06003.12 ORX68570.1 - 7.2e-07 28.7 5.5 0.00051 19.4 1.1 2.2 2 0 0 2 2 2 2 Survival motor neuron protein (SMN) DUF1509 PF07420.11 ORX68570.1 - 0.38 9.7 3.0 0.49 9.3 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) ORMDL PF04061.14 ORX68571.1 - 3.6e-54 182.3 6.4 4.2e-54 182.0 6.4 1.0 1 0 0 1 1 1 1 ORMDL family RhoGAP PF00620.27 ORX68573.1 - 2e-27 95.9 0.0 3.4e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.17 ORX68573.1 - 2.4e-20 73.0 0.0 5.4e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 MyTH4 domain SWIRM PF04433.17 ORX68574.1 - 1.4e-30 105.4 0.1 3.2e-30 104.3 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 ORX68574.1 - 7.7e-23 80.3 12.6 7.7e-23 80.3 12.6 2.1 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 ORX68574.1 - 8e-12 45.2 0.0 1.8e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX68574.1 - 8.5e-07 29.1 0.0 2.1e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX68574.1 - 0.071 13.0 0.9 0.65 9.9 0.0 2.7 2 0 0 2 2 2 0 Myb DNA-binding like ZZ PF00569.17 ORX68574.1 - 1.2 9.0 4.7 2.2 8.1 4.7 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type V_ATPase_I PF01496.19 ORX68574.1 - 9.6 4.0 13.2 0.63 7.9 2.7 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family HSF_DNA-bind PF00447.17 ORX68575.1 - 3.5e-31 107.7 0.2 4e-31 107.5 0.2 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 ORX68575.1 - 0.052 14.0 0.0 0.1 13.1 0.0 1.6 1 1 0 1 1 1 0 Ets-domain AP_endonuc_2_N PF07582.12 ORX68575.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 AP endonuclease family 2 C terminus p450 PF00067.22 ORX68577.1 - 8.5e-34 117.1 0.0 1.1e-33 116.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX68578.1 - 2.2e-74 250.9 0.0 2.8e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 ORX68580.1 - 9.1e-45 152.8 12.0 1.1e-44 152.5 12.0 1.0 1 0 0 1 1 1 1 RTA1 like protein FtsJ PF01728.19 ORX68581.1 - 3.6e-70 235.7 0.0 4.3e-70 235.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 ORX68581.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DUF4539 PF15072.6 ORX68582.1 - 2.5e-17 62.7 0.0 4.5e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) ABC1 PF03109.16 ORX68583.1 - 2.4e-32 111.6 0.0 4.5e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ORX68583.1 - 0.00087 18.7 0.0 0.044 13.1 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 ORX68583.1 - 0.001 18.7 0.1 0.014 15.0 0.0 2.3 2 0 0 2 2 2 1 RIO1 family MLIP PF15274.6 ORX68583.1 - 0.063 13.2 0.1 0.098 12.5 0.1 1.2 1 0 0 1 1 1 0 Muscular LMNA-interacting protein APH PF01636.23 ORX68583.1 - 0.068 13.1 0.7 0.46 10.4 0.5 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ala_racemase_N PF01168.20 ORX68584.1 - 2e-23 83.2 0.0 2.4e-23 82.9 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Lipase_GDSL_2 PF13472.6 ORX68584.1 - 0.041 14.3 0.1 8.9 6.7 0.0 2.1 1 1 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Phosphorylase PF00343.20 ORX68585.1 - 1.1e-303 1009.0 0.0 1.3e-303 1008.8 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase zf-AN1 PF01428.16 ORX68586.1 - 2.1e-07 31.0 10.7 3.7e-07 30.2 10.7 1.3 1 1 0 1 1 1 1 AN1-like Zinc finger Peptidase_C48 PF02902.19 ORX68588.1 - 1.2e-20 74.3 0.1 1.7e-20 73.8 0.1 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C48 PF02902.19 ORX68589.1 - 1e-09 38.6 0.0 1.4e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain AMP-binding PF00501.28 ORX68590.1 - 2e-79 267.2 0.0 3e-79 266.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX68590.1 - 1e-17 64.8 0.1 2.7e-17 63.5 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ank_4 PF13637.6 ORX68591.1 - 2.7e-22 78.8 0.2 2.5e-09 37.5 0.1 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX68591.1 - 1.4e-17 63.5 0.2 6.4e-12 45.5 0.1 2.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX68591.1 - 2.5e-17 63.2 0.7 1.4e-14 54.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ORX68591.1 - 2.2e-15 56.3 0.8 7.6e-06 26.1 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ORX68591.1 - 2.4e-12 45.9 0.5 3.4e-06 27.0 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeat Eaf7 PF07904.13 ORX68592.1 - 3.6e-15 56.2 7.3 3.6e-15 56.2 7.3 3.5 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 CBP_BcsF PF11120.8 ORX68592.1 - 0.053 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF SDA1 PF05285.12 ORX68592.1 - 0.21 11.0 57.5 0.53 9.6 28.7 2.1 2 0 0 2 2 2 0 SDA1 DUF4746 PF15928.5 ORX68592.1 - 0.38 10.1 21.3 0.34 10.3 8.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Mpp10 PF04006.12 ORX68592.1 - 1.2 7.5 47.1 1.9 6.9 22.1 2.1 2 0 0 2 2 2 0 Mpp10 protein Thioredoxin PF00085.20 ORX68593.1 - 2.8e-57 191.1 0.0 2.6e-29 101.2 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 ORX68593.1 - 3.2e-18 66.4 1.0 8.9e-18 65.0 1.0 1.7 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 ORX68593.1 - 2.2e-15 56.8 0.0 1.1e-08 34.8 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ORX68593.1 - 2.3e-13 50.6 0.4 4.8e-06 27.0 0.0 3.0 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ORX68593.1 - 6.9e-12 45.4 0.2 3.1e-05 24.1 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 ORX68593.1 - 7.8e-10 38.9 0.2 0.0021 18.4 0.1 3.5 2 1 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 ORX68593.1 - 1.1e-09 38.2 0.0 0.0021 18.0 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family ERp29_N PF07912.13 ORX68593.1 - 1.4e-07 31.7 0.2 5e-06 26.7 0.0 2.5 2 1 0 2 2 2 1 ERp29, N-terminal domain Redoxin PF08534.10 ORX68593.1 - 7.8e-07 28.9 0.4 0.027 14.2 0.0 2.8 2 1 0 2 2 2 2 Redoxin TraF PF13728.6 ORX68593.1 - 6.1e-05 23.0 0.0 0.34 10.7 0.0 2.4 2 0 0 2 2 2 2 F plasmid transfer operon protein HyaE PF07449.11 ORX68593.1 - 7.9e-05 22.6 0.0 0.17 11.9 0.0 2.6 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 ORX68593.1 - 0.0011 18.7 0.6 0.11 12.2 0.0 3.2 2 2 1 3 3 3 1 Thioredoxin DDE_Tnp_1_2 PF13586.6 ORX68593.1 - 0.0021 18.4 0.0 0.78 10.1 0.0 2.8 2 0 0 2 2 2 1 Transposase DDE domain Thioredoxin_4 PF13462.6 ORX68593.1 - 0.006 16.8 1.1 0.82 9.8 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_6 PF13848.6 ORX68593.1 - 0.011 15.7 0.3 0.12 12.2 0.2 2.7 2 1 0 2 2 2 0 Thioredoxin-like domain V-ATPase_G_2 PF16999.5 ORX68593.1 - 0.041 14.3 2.4 0.85 10.1 0.2 2.4 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Thioredoxin_9 PF14595.6 ORX68593.1 - 0.11 12.3 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin Thioredoxin PF00085.20 ORX68594.1 - 9.7e-17 60.9 0.0 2.6e-16 59.5 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 ORX68594.1 - 4.3e-06 26.3 0.0 6.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ORX68594.1 - 4.4e-06 27.1 0.1 2.5e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ORX68594.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.6 ORX68594.1 - 0.022 14.9 0.0 0.12 12.6 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 ORX68594.1 - 0.039 13.8 4.3 0.35 10.6 3.9 2.2 1 1 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 ORX68594.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like domain ERp29_N PF07912.13 ORX68594.1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 ERp29, N-terminal domain Thioredoxin_8 PF13905.6 ORX68594.1 - 0.11 12.8 0.2 3 8.2 0.0 2.5 2 1 1 3 3 3 0 Thioredoxin-like Thioredoxin_4 PF13462.6 ORX68594.1 - 0.45 10.7 3.7 1.7 8.8 0.0 2.9 2 2 1 3 3 3 0 Thioredoxin MerR_2 PF13591.6 ORX68595.1 - 1.1 9.2 0.0 1.1 9.2 0.0 3.8 4 1 0 4 4 4 0 MerR HTH family regulatory protein Sybindin PF04099.12 ORX68596.1 - 4.1e-48 163.0 0.1 5.5e-48 162.5 0.1 1.2 1 0 0 1 1 1 1 Sybindin-like family UCR_UQCRX_QCR9 PF05365.12 ORX68596.1 - 1.8e-13 50.2 4.5 3.2e-13 49.4 4.5 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Sedlin_N PF04628.13 ORX68596.1 - 6.1e-08 32.8 0.1 9.8e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Tricorn_C1 PF14684.6 ORX68596.1 - 0.00018 21.5 0.6 0.0012 18.9 0.2 2.1 2 0 0 2 2 2 1 Tricorn protease C1 domain EF-hand_13 PF17958.1 ORX68597.1 - 1e-23 83.0 0.0 2e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ORX68597.1 - 4e-15 56.0 0.2 1.9e-13 50.7 0.1 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX68597.1 - 1.3e-05 24.7 0.2 0.011 15.6 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 ORX68597.1 - 0.00028 20.2 0.1 0.058 13.0 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 ORX68597.1 - 0.0011 18.4 0.0 0.0045 16.4 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ORX68597.1 - 0.029 14.2 0.0 1.4 8.8 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair F-box-like PF12937.7 ORX68598.1 - 3.2e-05 23.7 0.1 8e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 ORX68599.1 - 0.00056 19.7 1.5 0.0016 18.3 1.5 1.9 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 ORX68600.1 - 1.6e-05 24.7 0.0 5.8e-05 22.9 0.0 2.1 1 0 0 1 1 1 1 F-box-like V_ATPase_I PF01496.19 ORX68601.1 - 3.7e-303 1007.5 0.0 4.4e-303 1007.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 ORX68601.1 - 0.3 11.3 2.0 10 6.3 0.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family THP2 PF09432.10 ORX68601.1 - 0.55 10.3 3.0 0.72 9.9 0.1 2.2 2 0 0 2 2 2 0 Tho complex subunit THP2 Rrn6 PF10214.9 ORX68602.1 - 9.1e-06 24.5 11.2 0.0041 15.7 9.4 2.2 2 0 0 2 2 2 2 RNA polymerase I-specific transcription-initiation factor UBA PF00627.31 ORX68603.1 - 9.7e-06 25.4 0.1 9.7e-06 25.4 0.1 1.6 2 0 0 2 2 2 1 UBA/TS-N domain YEATS PF03366.16 ORX68604.1 - 4.8e-33 113.0 0.4 7.1e-33 112.4 0.4 1.2 1 0 0 1 1 1 1 YEATS family bZIP_1 PF00170.21 ORX68604.1 - 0.066 13.3 0.3 0.098 12.8 0.3 1.3 1 0 0 1 1 1 0 bZIP transcription factor Ras PF00071.22 ORX68605.1 - 5.3e-67 224.4 0.0 6.7e-67 224.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX68605.1 - 7.8e-35 119.7 0.0 1.3e-34 118.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX68605.1 - 1.4e-14 53.9 0.0 1.7e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX68605.1 - 3.1e-06 26.9 0.0 4.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX68605.1 - 5.4e-05 22.7 0.0 6.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX68605.1 - 0.00043 20.2 0.1 1 9.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX68605.1 - 0.0006 19.9 0.1 0.0017 18.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX68605.1 - 0.0031 17.0 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ORX68605.1 - 0.036 14.5 0.0 0.098 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 ORX68605.1 - 0.046 13.3 0.0 0.36 10.4 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 ORX68605.1 - 0.085 12.6 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ORX68605.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ORX68605.1 - 0.15 12.3 0.0 0.67 10.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain Pkinase_fungal PF17667.1 ORX68607.1 - 2.8e-13 49.4 0.0 1.1e-08 34.3 0.0 3.1 3 0 0 3 3 3 3 Fungal protein kinase APH PF01636.23 ORX68607.1 - 3e-05 24.1 0.2 0.0002 21.4 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Ras PF00071.22 ORX68608.1 - 3.9e-09 36.3 0.0 4.5e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX68608.1 - 5.8e-05 23.3 0.0 7.3e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ORX68608.1 - 0.014 15.7 0.0 0.015 15.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ORX68608.1 - 0.05 13.3 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 ORX68608.1 - 0.093 12.8 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 ORX68608.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein Ras PF00071.22 ORX68609.1 - 7.8e-12 45.1 0.0 9e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Ras family FtsJ PF01728.19 ORX68615.1 - 1.6e-55 188.0 0.1 3.4e-55 186.9 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase Spb1_C PF07780.12 ORX68615.1 - 5e-50 170.1 26.4 7.7e-27 94.3 6.0 4.6 3 2 1 4 4 4 2 Spb1 C-terminal domain DUF3381 PF11861.8 ORX68615.1 - 2.7e-41 141.1 11.6 2.7e-41 141.1 11.6 5.0 3 2 2 5 5 5 1 Domain of unknown function (DUF3381) G-alpha PF00503.20 ORX68616.1 - 2.6e-110 368.9 0.6 3.3e-110 368.6 0.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX68616.1 - 1.2e-14 54.2 0.4 1.7e-09 37.4 0.2 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX68616.1 - 0.00023 20.6 0.1 0.32 10.3 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX68616.1 - 0.005 17.1 0.1 0.68 10.2 0.1 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SMP_C2CD2L PF18696.1 ORX68616.1 - 0.046 13.6 0.3 0.5 10.2 0.1 2.2 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain AAA_29 PF13555.6 ORX68616.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ribosomal_L14e PF01929.17 ORX68617.1 - 9.1e-29 99.8 5.9 1.6e-28 99.0 5.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ORX68617.1 - 1.1e-05 25.1 3.0 2.5e-05 24.1 2.5 1.8 2 0 0 2 2 2 1 KOW motif EPSP_synthase PF00275.20 ORX68618.1 - 2.7e-114 382.1 0.0 9e-86 288.2 0.0 2.4 1 1 1 2 2 2 2 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 ORX68618.1 - 1.5e-97 325.9 0.1 3.9e-97 324.5 0.0 1.7 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 ORX68618.1 - 1.1e-46 160.0 0.0 2.7e-46 158.7 0.0 1.7 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.22 ORX68618.1 - 6.4e-35 120.6 0.0 1.2e-33 116.4 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 ORX68618.1 - 2.8e-24 85.2 0.0 8.4e-24 83.6 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 ORX68618.1 - 1.1e-08 35.2 0.0 2.7e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 ORX68618.1 - 5.3e-08 32.9 0.3 2.1e-07 30.9 0.1 2.0 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 ORX68618.1 - 6.1e-08 32.3 0.0 1.6e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain AAA_18 PF13238.6 ORX68618.1 - 0.0013 19.2 0.0 0.0032 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX68618.1 - 0.0022 18.2 0.0 0.02 15.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX68618.1 - 0.027 14.9 0.0 0.073 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ThiF PF00899.21 ORX68618.1 - 0.029 13.7 0.2 0.24 10.7 0.1 2.1 2 0 0 2 2 2 0 ThiF family AAA_14 PF13173.6 ORX68618.1 - 0.065 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_processg_A PF02481.15 ORX68618.1 - 0.08 12.2 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 DNA recombination-mediator protein A Integrin_beta PF00362.18 ORX68618.1 - 0.093 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Integrin beta chain VWA domain Sacchrp_dh_NADP PF03435.18 ORX68618.1 - 0.13 12.5 0.2 12 6.1 0.0 3.8 4 0 0 4 4 4 0 Saccharopine dehydrogenase NADP binding domain AAA PF00004.29 ORX68618.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1688 PF07958.11 ORX68618.1 - 0.18 10.5 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) Kelch_1 PF01344.25 ORX68619.1 - 9.9e-12 44.2 10.0 0.023 14.3 0.2 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ORX68619.1 - 1e-07 32.0 12.2 0.049 13.9 0.1 6.3 6 1 1 7 7 7 3 Kelch motif Kelch_5 PF13854.6 ORX68619.1 - 0.014 15.4 5.7 1 9.4 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ORX68619.1 - 0.37 10.8 29.2 0.24 11.4 1.6 6.1 7 2 1 8 8 8 0 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX68619.1 - 0.8 10.1 16.5 1.7 9.0 0.1 5.1 4 1 1 5 5 5 0 Galactose oxidase, central domain Mito_carr PF00153.27 ORX68621.1 - 7.5e-49 163.6 4.3 8.8e-20 70.4 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX68621.1 - 0.0022 17.2 0.0 1.8 7.7 0.0 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease DUF3792 PF12670.7 ORX68621.1 - 0.14 12.3 4.1 0.86 9.8 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) Mito_carr PF00153.27 ORX68622.1 - 1.4e-57 191.6 5.2 1.3e-21 76.3 0.6 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX68622.1 - 0.0056 15.9 0.0 0.32 10.1 0.0 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease MDD_C PF18376.1 ORX68623.1 - 5.5e-73 244.7 0.1 7.6e-73 244.3 0.1 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ORX68623.1 - 1.3e-07 31.7 2.8 3.3e-07 30.4 2.8 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain DUF1819 PF08849.11 ORX68623.1 - 0.037 13.8 0.1 0.072 12.9 0.1 1.4 1 0 0 1 1 1 0 Putative inner membrane protein (DUF1819) PhoH PF02562.16 ORX68624.1 - 0.0034 16.8 0.0 0.0086 15.6 0.0 1.6 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 ORX68624.1 - 0.01 15.8 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DAP3 PF10236.9 ORX68624.1 - 0.03 13.5 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 ORX68624.1 - 0.046 13.6 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DNA_pol3_delta2 PF13177.6 ORX68624.1 - 0.086 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RNA_helicase PF00910.22 ORX68624.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 ORX68624.1 - 0.12 11.5 0.0 0.14 11.1 0.0 1.3 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.7 ORX68624.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain HAUS4 PF14735.6 ORX68625.1 - 5.3e-11 42.7 2.3 6.5e-11 42.4 2.3 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 MIEAP PF16026.5 ORX68625.1 - 0.0028 17.9 1.3 0.0052 17.0 1.0 1.6 2 0 0 2 2 2 1 Mitochondria-eating protein zf-MYND PF01753.18 ORX68626.1 - 2.8e-05 24.1 24.6 2.8e-05 24.1 24.6 2.1 2 1 0 2 2 2 1 MYND finger TFIIA PF03153.13 ORX68626.1 - 8.4e-05 22.7 24.3 8.4e-05 22.7 24.3 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 ORX68626.1 - 0.0015 17.6 8.9 0.0015 17.6 8.9 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Arm PF00514.23 ORX68626.1 - 0.017 15.2 0.0 0.58 10.3 0.1 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat SUIM_assoc PF16619.5 ORX68626.1 - 0.017 15.2 6.4 0.017 15.2 6.4 5.3 3 1 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 BCCT PF02028.17 ORX68626.1 - 0.18 10.2 0.0 0.27 9.6 0.0 1.3 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter SpoIIP PF07454.11 ORX68626.1 - 1.5 8.2 7.8 0.22 10.9 1.9 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 ORX68626.1 - 4.8 6.1 14.1 0.45 9.4 5.3 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Suf PF05843.14 ORX68626.1 - 6.7 6.6 26.6 1.6 8.6 11.7 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Med15 PF09606.10 ORX68626.1 - 7 5.2 54.7 0.11 11.1 25.1 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal SNARE PF05739.19 ORX68627.1 - 4.8e-13 48.9 0.8 1e-12 47.8 0.8 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 ORX68627.1 - 2.7e-06 27.2 4.0 0.0041 16.8 0.2 2.4 2 0 0 2 2 2 2 Syntaxin DUF948 PF06103.11 ORX68627.1 - 0.002 18.3 4.6 0.25 11.6 0.1 3.9 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF948) HrpB7 PF09486.10 ORX68627.1 - 0.082 13.3 0.1 0.082 13.3 0.1 2.2 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF16 PF01519.16 ORX68627.1 - 0.14 12.6 0.1 0.14 12.6 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 UPF0242 PF06785.11 ORX68627.1 - 0.15 12.1 6.4 5.3 7.1 0.1 3.2 2 2 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 ORX68627.1 - 0.45 10.6 4.6 1.7 8.7 0.2 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Use1 PF09753.9 ORX68627.1 - 0.5 10.0 7.8 0.47 10.1 0.2 2.5 2 1 0 2 2 2 0 Membrane fusion protein Use1 MerR-DNA-bind PF09278.11 ORX68627.1 - 0.58 10.7 3.9 7.4 7.2 0.5 3.2 2 2 1 3 3 3 0 MerR, DNA binding DUF2570 PF10828.8 ORX68627.1 - 0.75 9.6 8.6 1.1 9.1 1.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) LXG PF04740.12 ORX68627.1 - 0.97 9.1 7.9 0.5 10.0 1.2 2.6 2 1 0 2 2 2 0 LXG domain of WXG superfamily DUF745 PF05335.13 ORX68627.1 - 2.5 7.8 5.8 2 8.1 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) NPV_P10 PF05531.12 ORX68627.1 - 2.6 8.6 7.8 13 6.3 0.1 3.8 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ALIX_LYPXL_bnd PF13949.6 ORX68627.1 - 3.6 6.8 9.0 0.24 10.7 0.4 2.4 2 1 0 2 2 2 0 ALIX V-shaped domain binding to HIV FliJ PF02050.16 ORX68627.1 - 6 7.1 7.5 3.3 8.0 1.5 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein DUF5082 PF16888.5 ORX68627.1 - 6.3 7.1 8.0 10 6.4 1.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) PHP PF02811.19 ORX68629.1 - 5.4e-07 30.1 0.0 6.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 PHP domain AP_endonuc_2 PF01261.24 ORX68629.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Pyrophosphatase PF00719.19 ORX68630.1 - 3e-59 199.4 0.5 4.1e-59 199.0 0.5 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase SNARE PF05739.19 ORX68631.1 - 1.2e-16 60.4 5.7 1.2e-16 60.4 5.7 3.5 4 0 0 4 4 4 1 SNARE domain Syntaxin PF00804.25 ORX68631.1 - 2.5e-16 59.9 18.0 3.7e-16 59.4 15.9 2.2 1 1 0 1 1 1 1 Syntaxin Orf78 PF06024.12 ORX68631.1 - 0.00053 20.2 4.3 0.0017 18.7 4.3 1.9 1 0 0 1 1 1 1 Orf78 (ac78) PEP-utilisers_N PF05524.13 ORX68631.1 - 0.016 15.4 15.6 0.16 12.2 4.9 2.3 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF5383 PF17355.2 ORX68631.1 - 0.02 15.3 0.8 0.048 14.0 0.8 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5383) Synaptobrevin PF00957.21 ORX68631.1 - 0.025 14.4 17.8 0.2 11.4 14.0 2.7 2 1 0 2 2 2 0 Synaptobrevin DUF2207 PF09972.9 ORX68631.1 - 0.044 12.6 1.2 0.049 12.4 0.3 1.4 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) MCPsignal PF00015.21 ORX68631.1 - 0.055 13.3 9.7 0.15 11.9 4.6 2.3 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain IFT46_B_C PF12317.8 ORX68631.1 - 0.055 13.2 6.0 2.2 8.0 1.7 2.2 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Syntaxin_2 PF14523.6 ORX68631.1 - 0.076 13.4 12.6 0.71 10.3 6.8 2.7 2 1 0 2 2 2 0 Syntaxin-like protein PBP1_TM PF14812.6 ORX68631.1 - 0.15 12.5 2.8 0.15 12.5 0.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal VitD-bind_III PF09164.10 ORX68631.1 - 0.17 11.9 0.0 0.45 10.5 0.0 1.7 1 0 0 1 1 1 0 Vitamin D binding protein, domain III COesterase PF00135.28 ORX68631.1 - 0.18 10.7 2.3 0.22 10.3 2.3 1.2 1 0 0 1 1 1 0 Carboxylesterase family LXG PF04740.12 ORX68631.1 - 0.2 11.3 9.4 3.5 7.3 0.1 3.2 2 1 1 3 3 3 0 LXG domain of WXG superfamily Prominin PF05478.11 ORX68631.1 - 0.23 9.4 9.4 0.03 12.3 4.4 1.8 1 1 0 1 1 1 0 Prominin B2 PF11473.8 ORX68631.1 - 0.39 10.6 1.7 10 6.0 0.0 3.0 2 1 1 3 3 3 0 RNA binding protein B2 RIFIN PF02009.16 ORX68631.1 - 0.55 10.1 15.9 0.38 10.6 12.3 1.9 1 1 1 2 2 2 0 Rifin DUF2721 PF11026.8 ORX68631.1 - 0.71 9.8 10.0 0.37 10.7 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Pox_EPC_I2-L1 PF12575.8 ORX68631.1 - 1.2 9.4 7.6 0.72 10.1 5.5 1.8 2 0 0 2 2 1 0 Poxvirus entry protein complex L1 and I2 ISG65-75 PF11727.8 ORX68631.1 - 1.4 8.1 14.6 0.72 9.0 3.9 2.5 1 1 2 3 3 3 0 Invariant surface glycoprotein Laminin_II PF06009.12 ORX68631.1 - 1.7 8.7 11.0 0.095 12.7 1.7 2.6 2 1 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 ORX68631.1 - 1.7 8.7 9.6 1.2 9.2 4.2 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Neur_chan_memb PF02932.16 ORX68631.1 - 1.7 8.6 9.7 0.94 9.5 7.4 1.7 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region NPV_P10 PF05531.12 ORX68631.1 - 2.2 8.8 7.7 1.9 9.0 1.5 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Vac_Fusion PF02346.16 ORX68631.1 - 2.4 7.8 8.0 1.1 8.9 0.6 3.4 3 1 1 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Collectrin PF16959.5 ORX68631.1 - 2.5 7.9 12.3 12 5.6 9.0 2.6 2 1 0 2 2 2 0 Renal amino acid transporter TMPIT PF07851.13 ORX68631.1 - 3.8 6.7 9.0 0.54 9.5 0.6 2.4 2 1 1 3 3 3 0 TMPIT-like protein DUF5446 PF17522.2 ORX68631.1 - 4.6 7.5 8.2 3 8.1 4.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5446) SlyX PF04102.12 ORX68631.1 - 6.7 7.4 14.7 0.68 10.6 1.4 3.7 3 2 0 3 3 3 0 SlyX Fib_alpha PF08702.10 ORX68631.1 - 7.4 6.7 14.3 0.59 10.3 3.6 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin PF00804.25 ORX68632.1 - 3.9e-25 88.7 20.6 3.9e-25 88.7 20.6 1.3 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 ORX68632.1 - 8.6e-13 48.1 3.5 8.6e-13 48.1 3.5 3.4 4 0 0 4 4 4 1 SNARE domain Prominin PF05478.11 ORX68632.1 - 0.0012 16.9 11.4 0.013 13.5 1.6 2.0 2 0 0 2 2 2 2 Prominin Syntaxin_2 PF14523.6 ORX68632.1 - 0.003 17.9 15.7 0.0051 17.2 10.3 2.4 2 0 0 2 2 2 1 Syntaxin-like protein MCU PF04678.13 ORX68632.1 - 0.0035 17.5 2.6 0.0035 17.5 2.6 2.3 2 1 0 2 2 2 1 Mitochondrial calcium uniporter IFT46_B_C PF12317.8 ORX68632.1 - 0.038 13.7 8.2 1.1 9.0 0.6 2.7 2 1 1 3 3 3 0 Intraflagellar transport complex B protein 46 C terminal Glutaredoxin2_C PF04399.13 ORX68632.1 - 0.081 12.8 3.3 1.2 9.0 0.1 2.8 2 2 1 3 3 3 0 Glutaredoxin 2, C terminal domain VitD-bind_III PF09164.10 ORX68632.1 - 0.13 12.3 0.0 0.72 9.9 0.0 2.2 2 0 0 2 2 2 0 Vitamin D binding protein, domain III DUF2207 PF09972.9 ORX68632.1 - 0.19 10.5 0.8 0.28 9.9 0.0 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF5446 PF17522.2 ORX68632.1 - 0.21 11.8 10.1 1.3 9.2 5.3 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5446) DUF3040 PF11239.8 ORX68632.1 - 1.2 9.5 4.3 6.6 7.1 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) NPV_P10 PF05531.12 ORX68632.1 - 2.3 8.8 10.1 5.4 7.6 0.5 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 ORX68632.1 - 4.4 7.6 25.9 0.54 10.6 3.3 4.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) PIN_8 PF18476.1 ORX68632.1 - 4.9 6.9 15.9 2.2 8.1 7.1 2.4 1 1 1 2 2 2 0 PIN like domain Fib_alpha PF08702.10 ORX68632.1 - 5 7.3 16.8 2 8.6 0.7 3.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 ORX68632.1 - 6.9 6.7 8.3 29 4.7 3.3 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin PF00804.25 ORX68633.1 - 4.2e-16 59.2 20.1 1.8e-14 53.9 20.1 2.2 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 ORX68633.1 - 4.9e-15 55.3 3.9 4.9e-15 55.3 3.9 3.8 4 0 0 4 4 4 1 SNARE domain Prominin PF05478.11 ORX68633.1 - 4e-05 21.8 12.1 0.00038 18.6 2.5 2.0 2 0 0 2 2 2 2 Prominin Syntaxin_2 PF14523.6 ORX68633.1 - 0.00047 20.5 15.7 0.0043 17.4 8.8 2.5 2 0 0 2 2 2 1 Syntaxin-like protein Glutaredoxin2_C PF04399.13 ORX68633.1 - 0.0031 17.3 2.2 0.43 10.4 0.1 3.0 2 1 1 3 3 3 1 Glutaredoxin 2, C terminal domain PhoU_div PF01865.16 ORX68633.1 - 0.0036 16.7 5.6 0.14 11.5 0.4 2.4 2 0 0 2 2 2 2 Protein of unknown function DUF47 MCU PF04678.13 ORX68633.1 - 0.0045 17.1 1.5 0.0045 17.1 1.5 2.5 2 1 0 2 2 2 1 Mitochondrial calcium uniporter Orf78 PF06024.12 ORX68633.1 - 0.012 15.9 1.6 0.012 15.9 1.6 2.2 2 1 0 2 2 2 0 Orf78 (ac78) DUF2207 PF09972.9 ORX68633.1 - 0.02 13.7 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF16 PF01519.16 ORX68633.1 - 0.025 15.0 1.9 0.025 15.0 1.9 2.7 2 1 1 3 3 3 0 Protein of unknown function DUF16 GET2 PF08690.10 ORX68633.1 - 0.026 14.2 11.5 3.2 7.3 11.5 2.2 1 1 0 1 1 1 0 GET complex subunit GET2 DUF2990 PF11693.8 ORX68633.1 - 0.064 13.4 0.3 17 5.7 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF2990) DUF745 PF05335.13 ORX68633.1 - 0.065 12.9 21.5 0.71 9.6 8.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF5446 PF17522.2 ORX68633.1 - 0.08 13.1 10.0 0.2 11.8 4.3 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5446) MobC PF05713.11 ORX68633.1 - 0.099 13.1 2.9 20 5.8 0.0 3.4 3 0 0 3 3 3 0 Bacterial mobilisation protein (MobC) COG2 PF06148.11 ORX68633.1 - 0.12 12.5 11.0 1.4 9.0 0.5 2.8 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ArsA_ATPase PF02374.15 ORX68633.1 - 0.13 11.4 4.2 0.095 11.9 1.8 1.7 1 1 0 2 2 2 0 Anion-transporting ATPase Vac_Fusion PF02346.16 ORX68633.1 - 0.13 11.9 5.9 0.8 9.4 1.2 3.4 3 1 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 FlaC_arch PF05377.11 ORX68633.1 - 0.21 12.0 10.2 2.1 8.8 0.3 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 ORX68633.1 - 0.42 9.8 13.9 0.14 11.4 0.6 2.6 2 1 0 2 2 2 0 TMPIT-like protein DUF2203 PF09969.9 ORX68633.1 - 0.47 11.2 16.0 1.3 9.7 2.8 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DASH_Dam1 PF08653.10 ORX68633.1 - 0.61 9.9 1.8 5.6 6.8 0.2 2.7 2 0 0 2 2 2 0 DASH complex subunit Dam1 ASFV_J13L PF05568.11 ORX68633.1 - 0.76 9.5 5.7 1.5 8.5 5.7 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein PCRF PF03462.18 ORX68633.1 - 0.81 9.5 17.4 0.16 11.8 3.2 3.0 1 1 2 3 3 3 0 PCRF domain Laminin_II PF06009.12 ORX68633.1 - 1.1 9.2 16.0 0.088 12.8 2.5 3.0 2 1 0 2 2 2 0 Laminin Domain II ISG65-75 PF11727.8 ORX68633.1 - 1.2 8.3 11.8 1.4 8.1 1.9 2.6 2 1 1 3 3 3 0 Invariant surface glycoprotein DUF1664 PF07889.12 ORX68633.1 - 1.4 9.0 15.8 0.43 10.6 2.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) IFT46_B_C PF12317.8 ORX68633.1 - 1.5 8.5 12.8 1.7 8.3 2.5 2.5 1 1 2 3 3 3 0 Intraflagellar transport complex B protein 46 C terminal Fib_alpha PF08702.10 ORX68633.1 - 1.9 8.6 20.3 0.52 10.5 3.0 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 ORX68633.1 - 2.2 8.9 17.1 0.93 10.1 5.4 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Muted PF14942.6 ORX68633.1 - 2.3 8.5 19.5 0.91 9.9 4.7 2.7 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.12 ORX68633.1 - 2.5 8.7 13.4 2.1 8.9 1.0 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 ORX68633.1 - 2.8 8.0 10.6 2.5 8.1 0.5 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SKA1 PF07160.12 ORX68633.1 - 3.3 7.5 18.7 0.079 12.8 2.4 2.6 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF4519 PF15012.6 ORX68633.1 - 3.7 7.8 7.4 2.9 8.1 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Otopetrin PF03189.13 ORX68633.1 - 4 6.2 7.1 0.24 10.2 0.8 1.9 2 0 0 2 2 2 0 Otopetrin AKNA PF12443.8 ORX68633.1 - 4.1 8.1 13.4 0.22 12.2 0.4 3.1 3 1 0 3 3 3 0 AT-hook-containing transcription factor Tweety PF04906.13 ORX68633.1 - 5.6 5.5 13.2 0.46 9.1 3.0 2.4 2 1 1 3 3 3 0 Tweety CdvA PF18822.1 ORX68633.1 - 5.8 6.8 11.0 3.7 7.4 1.4 2.7 2 1 0 2 2 2 0 CdvA-like coiled-coil domain CENP-O PF09496.10 ORX68633.1 - 6.1 6.8 15.6 1 9.3 3.9 2.3 1 1 1 2 2 2 0 Cenp-O kinetochore centromere component DUF3958 PF13125.6 ORX68633.1 - 7.3 6.8 14.9 0.19 12.0 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3958) Ribonuc_red_sm PF00268.21 ORX68634.1 - 2.5e-119 397.9 0.5 3e-119 397.6 0.5 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Peptidase_M28 PF04389.17 ORX68636.1 - 4e-31 108.3 0.0 6.5e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 ORX68636.1 - 0.0086 15.1 0.0 0.05 12.6 0.0 1.9 1 1 1 2 2 2 1 M42 glutamyl aminopeptidase Abhydrolase_9_N PF15420.6 ORX68637.1 - 0.00057 19.9 2.4 0.00097 19.2 2.4 1.4 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus KleE PF17394.2 ORX68637.1 - 0.0071 16.6 2.0 0.012 15.8 0.2 2.2 2 1 0 2 2 2 1 Uncharacterized KleE stable inheritance protein RTA1 PF04479.13 ORX68638.1 - 1.7e-39 135.6 14.9 8.7e-38 130.0 14.9 2.1 1 1 0 1 1 1 1 RTA1 like protein Lung_7-TM_R PF06814.13 ORX68640.1 - 1.4e-54 185.4 12.5 1.6e-54 185.2 12.5 1.0 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ORX68640.1 - 0.00039 19.9 0.3 0.00039 19.9 0.3 2.2 2 0 0 2 2 2 2 Rhodopsin-like GPCR transmembrane domain DcpS_C PF11969.8 ORX68641.1 - 1.2e-34 119.1 0.0 2.6e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 ORX68641.1 - 1.1e-18 67.9 0.0 1.8e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 ORX68641.1 - 0.0021 18.7 0.4 0.0044 17.7 0.4 1.4 1 0 0 1 1 1 1 HIT domain MFS_1 PF07690.16 ORX68642.1 - 2.1e-19 69.7 40.7 3.3e-19 69.0 40.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Lge1 PF11488.8 ORX68642.1 - 0.12 12.6 0.2 0.24 11.6 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 OPT PF03169.15 ORX68643.1 - 8.3e-141 470.6 46.5 9.3e-141 470.5 46.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein UCH PF00443.29 ORX68644.1 - 8.2e-28 97.6 0.0 2.5e-27 96.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ORX68644.1 - 6.5e-14 52.0 0.7 1.2e-13 51.1 0.7 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ORX68644.1 - 0.00077 19.1 0.1 0.023 14.3 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF2336 PF10098.9 ORX68644.1 - 0.02 14.3 0.1 0.037 13.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) GAS PF13851.6 ORX68647.1 - 0.041 13.2 0.1 0.13 11.6 0.1 1.8 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RNase_P_Rpp14 PF01900.19 ORX68648.1 - 3.3e-32 110.8 0.1 5e-32 110.2 0.1 1.3 1 0 0 1 1 1 1 Rpp14/Pop5 family p450 PF00067.22 ORX68649.1 - 1.3e-76 258.2 0.0 1.7e-76 257.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX68650.1 - 3.2e-75 253.6 0.0 4.1e-75 253.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TSP9 PF11493.8 ORX68650.1 - 0.0014 19.3 0.0 0.64 10.7 0.0 2.4 2 0 0 2 2 2 2 Thylakoid soluble phosphoprotein TSP9 p450 PF00067.22 ORX68651.1 - 2.9e-74 250.5 0.0 3.7e-74 250.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX68652.1 - 1.8e-72 244.6 0.0 2.3e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FRG1 PF06229.12 ORX68653.1 - 2.2e-22 79.7 0.5 3.7e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 ORX68653.1 - 0.0018 18.5 0.1 0.0083 16.3 0.0 2.1 3 0 0 3 3 3 1 Fascin domain AP3D1 PF06375.11 ORX68653.1 - 0.047 13.9 1.0 0.047 13.9 1.0 2.0 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF952 PF06108.12 ORX68653.1 - 0.071 13.1 0.7 9.9 6.2 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF952) Q_salvage PF10343.9 ORX68654.1 - 1.3e-29 103.7 0.0 2e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Sugar_tr PF00083.24 ORX68655.1 - 1.8e-83 280.9 21.9 6.5e-50 170.3 2.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX68655.1 - 2.1e-35 122.3 23.3 2.1e-35 122.3 23.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX68655.1 - 0.00093 17.7 5.3 0.00093 17.7 5.3 2.2 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 ORX68655.1 - 0.0017 17.7 6.9 0.0017 17.7 6.9 3.1 2 1 1 3 3 3 2 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ORX68655.1 - 0.0049 15.3 10.9 0.052 11.9 1.2 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 ORX68655.1 - 0.79 8.5 15.9 0.13 11.1 4.9 3.0 3 0 0 3 3 3 0 MFS_1 like family PDCD2_C PF04194.13 ORX68656.1 - 2.1e-36 125.6 1.8 1.4e-35 122.9 0.1 2.4 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 ORX68656.1 - 2.8e-08 33.7 10.5 2.8e-08 33.7 10.5 3.0 3 0 0 3 3 3 1 MYND finger Prok-RING_2 PF14445.6 ORX68656.1 - 0.024 14.8 4.8 0.13 12.5 2.3 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 2 zf-HIT PF04438.16 ORX68656.1 - 0.025 14.5 5.3 0.025 14.5 5.3 2.8 4 0 0 4 4 4 0 HIT zinc finger DNA_pol_phi PF04931.13 ORX68656.1 - 8.9 4.3 6.3 13 3.8 6.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi BTD PF09270.10 ORX68658.1 - 2.4e-19 70.1 0.0 4.9e-19 69.1 0.0 1.5 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain WD40 PF00400.32 ORX68659.1 - 0.00035 21.3 0.4 0.98 10.4 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ORX68659.1 - 0.034 12.8 0.5 0.84 8.2 0.1 2.1 1 1 0 2 2 2 0 Nucleoporin Nup120/160 CHS5_N PF16892.5 ORX68660.1 - 1.1e-22 79.7 0.1 1.8e-22 79.0 0.1 1.3 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus fn3_2 PF16893.5 ORX68660.1 - 5.3e-22 77.8 0.0 7.9e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain PTCB-BRCT PF12738.7 ORX68660.1 - 1e-11 44.6 0.0 1.6e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 ORX68660.1 - 6.4e-08 32.9 0.0 1.7e-07 31.5 0.0 1.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX68660.1 - 0.013 15.9 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF3006 PF11213.8 ORX68660.1 - 0.018 15.3 0.0 0.04 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) fn3 PF00041.21 ORX68660.1 - 0.19 12.1 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain DNA_ligase_OB PF03120.16 ORX68662.1 - 0.0082 16.0 1.0 0.014 15.3 1.0 1.3 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain Homeodomain PF00046.29 ORX68663.1 - 4e-21 74.6 1.5 4.4e-21 74.5 1.5 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX68663.1 - 0.0042 17.0 0.6 0.0067 16.3 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain DUF4956 PF16316.5 ORX68663.1 - 0.16 11.6 0.0 0.2 11.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Myb_DNA-binding PF00249.31 ORX68667.1 - 8.8e-06 25.8 0.1 3.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain U-box PF04564.15 ORX68667.1 - 0.042 14.0 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 U-box domain SnAC PF14619.6 ORX68667.1 - 1.3 9.6 7.0 0.26 11.9 1.1 2.7 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex ATP-synt_C PF00137.21 ORX68668.1 - 2.2e-27 95.2 27.3 1.8e-15 57.0 11.9 2.5 2 0 0 2 2 2 2 ATP synthase subunit C DUF3671 PF12420.8 ORX68668.1 - 0.85 9.7 5.0 0.45 10.6 0.5 2.2 1 1 0 2 2 2 0 Protein of unknown function HMG_box PF00505.19 ORX68669.1 - 8.4e-13 48.5 0.1 1.3e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX68669.1 - 0.016 15.8 0.1 0.029 15.0 0.1 1.4 1 0 0 1 1 1 0 HMG-box domain AHH PF14412.6 ORX68669.1 - 0.55 10.3 2.6 0.81 9.8 0.0 2.4 3 0 0 3 3 3 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH CAP_N PF01213.19 ORX68669.1 - 2.4 7.6 6.6 4 6.8 6.6 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HMG_box PF00505.19 ORX68670.1 - 1.1e-18 67.4 0.3 3.1e-18 65.9 0.3 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX68670.1 - 3.5e-10 40.3 0.2 3.5e-10 40.3 0.2 2.2 2 0 0 2 2 2 1 HMG-box domain YL1 PF05764.13 ORX68670.1 - 2.4 8.2 26.6 4.3 7.4 26.1 1.6 1 1 0 1 1 1 0 YL1 nuclear protein DUF2052 PF09747.9 ORX68670.1 - 3.6 7.7 16.0 6.7 6.8 15.2 2.0 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) BSP_II PF05432.11 ORX68670.1 - 6.8 6.3 19.8 18 4.9 19.8 1.7 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) EF-hand_1 PF00036.32 ORX68671.1 - 7.5e-05 22.0 0.0 0.0002 20.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ORX68671.1 - 0.00012 21.3 0.0 0.00028 20.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ORX68671.1 - 0.0016 18.2 0.0 0.0063 16.4 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ORX68671.1 - 0.008 16.6 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair F-box-like PF12937.7 ORX68671.1 - 0.011 15.7 0.1 0.031 14.2 0.0 1.8 2 0 0 2 2 2 0 F-box-like SPARC_Ca_bdg PF10591.9 ORX68671.1 - 0.035 14.4 0.0 0.063 13.6 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region ANAPC3 PF12895.7 ORX68671.1 - 0.1 12.9 0.2 0.19 12.0 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 F-box PF00646.33 ORX68671.1 - 0.17 11.8 0.0 0.7 9.8 0.0 1.9 2 0 0 2 2 2 0 F-box domain PTCB-BRCT PF12738.7 ORX68672.1 - 5.8e-21 74.2 0.0 1.1e-11 44.5 0.0 3.5 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 ORX68672.1 - 7.8e-20 71.0 0.4 2.4e-07 31.0 0.0 3.7 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX68672.1 - 0.0033 17.8 0.2 0.92 10.0 0.0 3.2 3 1 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ORX68672.1 - 0.033 14.5 0.0 0.46 10.8 0.0 2.9 3 0 0 3 3 3 0 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 ORX68672.1 - 0.15 12.1 0.0 8.6 6.5 0.0 2.9 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ORX68673.1 - 6.4e-24 83.7 0.7 4.7e-09 36.1 0.0 3.3 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.26 ORX68673.1 - 8.8e-17 61.3 1.5 2.9e-07 30.7 0.2 3.1 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX68673.1 - 5.8e-05 23.4 0.3 0.0041 17.5 0.1 2.4 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain CDC24_OB3 PF17244.2 ORX68674.1 - 0.011 15.4 1.0 0.011 15.4 1.0 1.0 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 zf-C2H2_4 PF13894.6 ORX68674.1 - 0.042 14.7 2.4 0.042 14.7 2.4 2.0 1 1 1 2 2 2 0 C2H2-type zinc finger Ribosomal_S17e PF00833.18 ORX68675.1 - 2e-60 202.1 0.1 2.5e-60 201.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 Steroid_dh PF02544.16 ORX68676.1 - 1.4e-38 132.2 1.5 1.4e-38 132.2 1.5 1.6 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 ORX68676.1 - 2.5e-06 27.1 0.1 4.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_4 PF18036.1 ORX68676.1 - 0.0012 18.9 0.5 0.013 15.5 0.5 2.3 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 ORX68676.1 - 0.024 14.5 0.1 0.042 13.7 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DnaJ PF00226.31 ORX68676.1 - 0.03 14.4 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain Ubiquitin_2 PF14560.6 ORX68676.1 - 0.072 13.5 0.1 0.16 12.5 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Cytokin_check_N PF10407.9 ORX68676.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Xpo1 PF08389.12 ORX68677.1 - 2.2e-34 118.7 0.0 8.5e-34 116.8 0.0 2.1 2 0 0 2 2 2 1 Exportin 1-like protein HEAT_EZ PF13513.6 ORX68677.1 - 5.9e-05 23.5 1.7 1.4 9.5 0.1 4.7 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 ORX68677.1 - 0.028 14.7 2.1 4.1 7.9 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat IBN_N PF03810.19 ORX68677.1 - 0.028 14.3 0.6 0.15 12.0 0.1 2.5 2 0 0 2 2 2 0 Importin-beta N-terminal domain PEMT PF04191.13 ORX68679.1 - 7.2e-50 167.8 20.3 1e-29 103.0 2.0 2.9 3 0 0 3 3 3 2 Phospholipid methyltransferase HECW_N PF16562.5 ORX68679.1 - 0.071 12.9 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DUF4199 PF13858.6 ORX68679.1 - 0.56 10.6 0.1 0.56 10.6 0.1 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF4199) CtnDOT_TraJ PF07863.11 ORX68680.1 - 3.5 8.3 7.0 2.2 9.0 0.1 2.9 2 1 1 3 3 3 0 Homologues of TraJ from Bacteroides conjugative transposon EF-hand_1 PF00036.32 ORX68681.1 - 8.3e-16 56.3 0.1 4.6e-07 28.9 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ORX68681.1 - 8.9e-15 53.3 0.2 2.8e-07 29.9 0.0 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.6 ORX68681.1 - 4.3e-14 52.6 0.0 2.4e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ORX68681.1 - 8.5e-14 51.8 0.1 4.3e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ORX68681.1 - 7.9e-09 35.2 2.4 1.2e-06 28.3 0.0 3.9 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 ORX68681.1 - 2.9e-07 29.7 0.6 2.9e-05 23.3 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_11 PF08976.11 ORX68681.1 - 0.0013 19.5 0.0 0.0023 18.7 0.0 1.4 1 1 0 1 1 1 1 EF-hand domain Metallophos PF00149.28 ORX68683.1 - 2e-20 74.2 4.1 3.1e-20 73.5 4.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX68683.1 - 2.3e-07 31.2 0.2 1.5e-06 28.5 0.2 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PGA_cap PF09587.10 ORX68683.1 - 0.047 13.1 1.1 0.15 11.5 1.1 1.9 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Ribosomal_L31e PF01198.19 ORX68685.1 - 3.2e-41 139.4 1.3 4e-41 139.1 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e CBM_21 PF03370.13 ORX68686.1 - 4.9e-28 97.6 0.0 7.5e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ORX68686.1 - 5.2e-11 43.0 0.0 9.4e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Ank_4 PF13637.6 ORX68687.1 - 1.1e-08 35.5 0.5 3.5e-05 24.3 0.1 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX68687.1 - 1.1e-06 28.8 0.3 1.7e-05 25.0 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ORX68687.1 - 2.6e-06 27.6 0.4 0.00072 19.8 0.1 2.8 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX68687.1 - 1.4e-05 25.6 0.1 0.0051 17.4 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX68687.1 - 0.0011 19.3 0.3 0.016 15.7 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeat Mito_carr PF00153.27 ORX68688.1 - 5.7e-46 154.4 3.7 9.1e-19 67.2 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein 6PF2K PF01591.18 ORX68689.1 - 7.2e-70 234.8 0.2 1.1e-69 234.2 0.2 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX68689.1 - 7e-12 45.4 0.0 1.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Hep_59 PF07052.11 ORX68689.1 - 1.4e-05 25.8 4.9 0.023 15.5 0.1 3.0 3 0 0 3 3 3 2 Hepatocellular carcinoma-associated antigen 59 AAA_33 PF13671.6 ORX68689.1 - 8e-05 22.8 0.0 0.0003 21.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain NmrA PF05368.13 ORX68691.1 - 4e-40 137.8 0.0 5.1e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX68691.1 - 3.6e-13 49.8 0.1 6.5e-13 49.0 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ORX68691.1 - 3.3e-09 36.6 0.1 5.5e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX68691.1 - 1.3e-07 30.9 0.1 1.9e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 ORX68691.1 - 6.9e-05 23.1 0.1 0.0011 19.2 0.1 2.3 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 ORX68691.1 - 0.00023 20.7 0.0 0.00086 18.8 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ORX68691.1 - 0.00024 21.1 0.0 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.24 ORX68691.1 - 0.00047 20.6 0.1 0.00087 19.7 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX68691.1 - 0.079 13.1 0.0 0.58 10.3 0.0 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Peptidase_M16_C PF05193.21 ORX68692.1 - 1.1e-10 41.8 0.0 1.8e-05 24.8 0.0 3.5 2 1 1 3 3 3 2 Peptidase M16 inactive domain ABC_tran PF00005.27 ORX68694.1 - 2.6e-12 47.4 0.0 1.1e-11 45.4 0.0 1.8 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68694.1 - 0.00028 20.4 0.2 0.017 14.6 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 ORX68695.1 - 7.2e-30 104.3 0.0 1.6e-29 103.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68695.1 - 1.8e-05 24.3 0.4 0.0073 15.8 0.1 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX68695.1 - 0.0053 16.8 0.1 0.014 15.5 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF87 PF01935.17 ORX68695.1 - 0.024 14.8 0.1 0.047 13.8 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain MeaB PF03308.16 ORX68695.1 - 0.031 13.3 0.0 0.055 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 ORX68695.1 - 0.059 12.4 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 ORX68695.1 - 0.061 13.1 0.0 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.6 ORX68695.1 - 0.08 12.7 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX68695.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 ORX68695.1 - 0.2 11.7 1.3 19 5.3 0.1 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) FHA PF00498.26 ORX68696.1 - 4.7e-11 42.9 0.4 8.9e-11 42.0 0.4 1.5 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 ORX68696.1 - 0.0083 16.3 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain Kunitz_BPTI PF00014.23 ORX68696.1 - 0.16 12.2 0.3 0.74 10.1 0.1 2.0 2 0 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain F_bP_aldolase PF01116.20 ORX68697.1 - 2.8e-88 296.0 0.0 3.2e-88 295.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Nramp PF01566.18 ORX68698.1 - 6.3e-70 235.9 16.8 2.7e-33 115.5 1.8 3.2 3 0 0 3 3 3 3 Natural resistance-associated macrophage protein NAD_binding_1 PF00175.21 ORX68699.1 - 3.1e-31 108.3 0.0 4.6e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX68699.1 - 1.9e-24 85.9 0.0 3e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ORX68699.1 - 7.1e-09 36.0 0.0 1.5e-05 25.2 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ORX68699.1 - 0.006 16.8 0.0 0.013 15.7 0.0 1.6 2 0 0 2 2 2 1 Siderophore-interacting FAD-binding domain THUMP PF02926.17 ORX68700.1 - 0.00041 20.5 1.0 0.0018 18.4 0.1 2.0 1 1 0 2 2 2 1 THUMP domain zf-RING_2 PF13639.6 ORX68701.1 - 0.079 13.3 11.2 0.44 10.9 7.5 3.3 2 1 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 ORX68701.1 - 7.1 7.0 11.0 0.5 10.7 5.3 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ORX68703.1 - 3.3e-07 30.5 7.4 4.3e-07 30.2 4.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ORX68703.1 - 5.8e-07 29.7 4.0 6.3e-07 29.6 2.4 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX68703.1 - 3.6e-05 23.5 1.5 3.6e-05 23.5 1.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX68703.1 - 0.00019 21.2 2.5 0.00019 21.2 2.5 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX68703.1 - 0.0043 17.1 0.7 0.012 15.6 0.7 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ORX68703.1 - 0.0082 15.9 1.8 0.0082 15.9 1.8 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ORX68703.1 - 0.13 12.2 2.7 0.31 10.9 2.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ORX68703.1 - 0.46 10.7 4.6 5.8 7.2 4.6 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ORX68703.1 - 0.68 9.6 3.2 20 4.9 4.2 2.4 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ORX68703.1 - 1.2 9.0 9.0 0.043 13.7 2.6 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Pkinase PF00069.25 ORX68704.1 - 1.6e-57 194.9 1.0 3.2e-45 154.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX68704.1 - 1.7e-14 53.7 0.1 4.9e-07 29.3 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ORX68704.1 - 9.2e-08 32.3 0.1 1.1e-06 28.8 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX68704.1 - 0.018 13.9 0.0 0.032 13.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 ORX68704.1 - 0.019 14.6 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX68704.1 - 0.024 14.0 0.8 0.059 12.7 0.3 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX68704.1 - 0.036 13.4 0.1 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Kinase-like SPP PF06550.11 ORX68706.1 - 0.17 11.4 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease Pkinase PF00069.25 ORX68707.1 - 1.1e-57 195.4 0.0 1.3e-57 195.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX68707.1 - 4.6e-43 147.4 0.0 4.9e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX68707.1 - 2.3e-07 29.9 0.1 2.4e-07 29.9 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX68707.1 - 2.2e-06 27.2 0.0 3.9e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX68707.1 - 0.00042 19.4 0.0 0.0005 19.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX68707.1 - 0.0011 18.4 0.1 0.0025 17.2 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX68707.1 - 0.0046 16.9 0.0 0.092 12.6 0.0 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 ORX68707.1 - 0.035 13.7 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ORX68707.1 - 0.042 13.4 0.1 0.054 13.1 0.1 1.2 1 0 0 1 1 1 0 RIO1 family EF-hand_13 PF17958.1 ORX68707.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain CTNNBL PF08216.11 ORX68708.1 - 6.3e-28 97.0 0.3 1.5e-27 95.8 0.3 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear TIMELESS PF04821.14 ORX68708.1 - 0.059 12.6 0.5 0.17 11.1 0.1 2.0 2 0 0 2 2 2 0 Timeless protein DUF3082 PF11282.8 ORX68708.1 - 0.11 12.8 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3082) Mito_carr PF00153.27 ORX68709.1 - 5.5e-41 138.4 2.6 8.9e-19 67.2 0.0 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein DUF3325 PF11804.8 ORX68709.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3325) Cyt-b5 PF00173.28 ORX68710.1 - 2e-26 91.9 0.0 2.5e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ELL PF10390.9 ORX68711.1 - 0.00021 20.9 0.1 0.00045 19.8 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 ORX68711.1 - 0.015 16.0 0.2 0.42 11.4 0.1 2.8 2 0 0 2 2 2 0 Occludin homology domain ERM PF00769.19 ORX68711.1 - 2.2 8.0 9.9 0.25 11.1 0.8 2.6 2 1 0 2 2 2 0 Ezrin/radixin/moesin family TPT PF03151.16 ORX68712.1 - 2.9e-26 92.5 22.6 3.4e-26 92.3 22.6 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ORX68712.1 - 5e-07 30.0 35.2 0.00016 21.9 11.9 2.2 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ORX68712.1 - 3.1e-06 26.6 24.5 3.8e-06 26.4 24.5 1.1 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport MtN3_slv PF03083.16 ORX68712.1 - 5.2 7.2 14.5 0.59 10.2 0.5 3.2 3 1 1 4 4 4 0 Sugar efflux transporter for intercellular exchange TAF6_C PF07571.13 ORX68713.1 - 2.5e-33 114.2 0.1 7.3e-33 112.8 0.1 1.8 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 ORX68713.1 - 2.2e-26 91.8 1.2 9.7e-25 86.5 0.1 2.5 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 ORX68713.1 - 0.0036 17.7 0.2 0.011 16.0 0.2 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 MMS19_C PF12460.8 ORX68713.1 - 0.041 13.0 2.7 0.12 11.5 2.3 1.9 1 1 1 2 2 2 0 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 ORX68713.1 - 0.055 14.0 1.0 30 5.3 0.0 3.9 5 0 0 5 5 5 0 HEAT-like repeat MFS_1 PF07690.16 ORX68714.1 - 5.3e-39 134.1 66.6 7.8e-33 113.8 37.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX68714.1 - 3e-16 59.3 22.7 7.1e-15 54.8 3.3 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 ORX68714.1 - 0.00036 19.1 1.4 0.0006 18.4 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Adeno_E3_CR2 PF02439.15 ORX68716.1 - 0.22 11.3 0.7 0.31 10.8 0.7 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 VTC PF09359.10 ORX68717.1 - 2.6e-70 237.0 4.3 3.1e-70 236.7 0.2 2.5 2 1 0 2 2 2 1 VTC domain DUF202 PF02656.15 ORX68717.1 - 3.5e-09 37.0 0.4 5.5e-09 36.3 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 ORX68717.1 - 4.9e-07 30.0 33.3 0.00013 22.1 1.3 4.5 2 2 3 5 5 5 3 SPX domain BLOC1_2 PF10046.9 ORX68717.1 - 0.019 15.3 0.5 0.019 15.3 0.5 1.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Gemini_coat PF00844.18 ORX68717.1 - 0.047 13.1 0.1 0.047 13.1 0.1 1.6 2 0 0 2 2 2 0 Geminivirus coat protein/nuclear export factor BR1 family DUF202 PF02656.15 ORX68718.1 - 3.6e-09 36.9 1.0 4.8e-09 36.5 1.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF202) DUF202 PF02656.15 ORX68719.1 - 9.9e-16 57.9 6.5 1.1e-15 57.8 5.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF2637 PF10935.8 ORX68719.1 - 0.015 15.2 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) DUF4131 PF13567.6 ORX68719.1 - 0.016 14.9 1.8 0.023 14.3 0.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Phage_holin_3_6 PF07332.11 ORX68719.1 - 0.038 14.0 0.2 0.038 14.0 0.2 1.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Clc-like PF07062.12 ORX68719.1 - 0.14 11.6 1.3 0.21 11.0 1.3 1.4 1 1 0 1 1 1 0 Clc-like DUF2615 PF11027.8 ORX68719.1 - 0.35 11.0 0.8 0.64 10.2 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) GatB_N PF02934.15 ORX68725.1 - 6.8e-86 288.0 0.0 3.5e-79 266.0 0.0 2.1 2 0 0 2 2 2 2 GatB/GatE catalytic domain GatB_Yqey PF02637.18 ORX68725.1 - 1.6e-33 115.7 0.1 4.6e-33 114.2 0.1 1.7 2 0 0 2 2 2 1 GatB domain DUF4799 PF16056.5 ORX68725.1 - 0.00026 20.3 0.0 0.00044 19.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4799) Fungal_trans PF04082.18 ORX68726.1 - 5.5e-16 58.4 0.0 1e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX68726.1 - 7.2e-08 32.4 15.7 1.5e-07 31.4 15.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_1 PF00561.20 ORX68727.1 - 0.0018 18.0 0.1 0.0038 16.9 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX68727.1 - 0.026 13.8 0.5 0.1 11.9 0.4 1.9 2 1 0 2 2 2 0 Serine aminopeptidase, S33 PPR PF01535.20 ORX68728.1 - 9.8e-07 28.6 0.0 0.37 11.2 0.0 5.0 5 0 0 5 5 5 1 PPR repeat PPR_2 PF13041.6 ORX68728.1 - 0.00016 21.8 0.0 8.2 6.7 0.0 4.7 4 0 0 4 4 4 1 PPR repeat family PPR_1 PF12854.7 ORX68728.1 - 0.0056 16.4 0.1 3 7.6 0.0 2.8 2 0 0 2 2 2 2 PPR repeat TPR_7 PF13176.6 ORX68728.1 - 0.051 13.6 0.1 19 5.6 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX68728.1 - 0.11 13.2 11.5 13 6.6 0.7 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat RseA_C PF03873.13 ORX68728.1 - 0.18 12.0 3.0 1.4 9.3 3.8 2.1 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain HIG_1_N PF04588.13 ORX68728.1 - 1.2 9.5 4.0 8.1 6.7 0.1 3.0 3 0 0 3 3 3 0 Hypoxia induced protein conserved region TPR_14 PF13428.6 ORX68728.1 - 2.9 9.0 27.1 16 6.7 0.0 8.2 7 2 1 9 9 9 0 Tetratricopeptide repeat DUF2009 PF09418.10 ORX68729.1 - 2.1e-182 607.3 0.1 2.7e-181 603.6 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 ORX68729.1 - 1.5e-05 25.1 9.4 3.2e-05 24.0 9.4 1.5 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.21 ORX68729.1 - 0.17 12.2 7.7 0.49 10.7 7.7 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Cript PF10235.9 ORX68729.1 - 0.78 10.4 5.7 1.5 9.4 5.7 1.5 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT CRC_subunit PF08624.10 ORX68730.1 - 5e-24 85.3 0.0 8e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Use1 PF09753.9 ORX68730.1 - 4.1 7.0 7.6 8.8 6.0 7.6 1.5 1 0 0 1 1 1 0 Membrane fusion protein Use1 Prenylcys_lyase PF07156.14 ORX68731.1 - 2.7e-34 118.8 0.4 2.1e-23 83.0 0.1 2.9 1 1 1 2 2 2 2 Prenylcysteine lyase Amino_oxidase PF01593.24 ORX68731.1 - 4.5e-07 29.5 0.2 1.1e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 ORX68731.1 - 0.048 13.6 0.1 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding V-SNARE PF05008.15 ORX68732.1 - 9.6e-15 54.7 1.4 9.6e-15 54.7 1.4 2.0 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ORX68732.1 - 0.0008 19.7 0.4 0.0038 17.5 0.0 2.2 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Plasmid_RAQPRD PF09686.10 ORX68732.1 - 0.015 15.5 1.9 0.029 14.6 1.2 1.9 1 1 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Exonuc_VII_L PF02601.15 ORX68732.1 - 0.2 11.2 3.0 0.23 11.0 3.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 ORX68732.1 - 0.41 11.2 5.7 1.1 9.7 5.7 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region MRP-L46 PF11788.8 ORX68734.1 - 2.9e-09 37.7 0.3 6.4e-09 36.6 0.3 1.6 1 1 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 ORX68734.1 - 0.0092 16.0 1.4 0.0092 16.0 1.4 2.7 2 1 1 3 3 3 1 NUDIX domain HATPase_c_3 PF13589.6 ORX68735.1 - 1.7e-09 37.6 0.1 3.8e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX68735.1 - 0.00026 21.5 0.0 0.00054 20.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TRAUB PF08164.12 ORX68736.1 - 3.3e-31 107.6 0.1 1.4e-30 105.6 0.1 2.2 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 ORX68736.1 - 6.2e-30 104.7 0.3 6.2e-30 104.7 0.3 3.4 3 2 0 3 3 3 1 Apoptosis antagonizing transcription factor PSCyt2 PF07583.11 ORX68736.1 - 0.0069 16.3 0.2 0.014 15.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1549) Adeno_PV PF03910.13 ORX68736.1 - 0.05 12.3 0.3 0.083 11.6 0.3 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV Ketoacyl-synt_C PF02801.22 ORX68737.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain IU_nuc_hydro PF01156.19 ORX68738.1 - 1.4e-91 307.3 0.2 1.6e-91 307.0 0.2 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase baeRF_family11 PF18855.1 ORX68738.1 - 0.05 13.9 0.0 0.093 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 11 DUF3726 PF12525.8 ORX68738.1 - 0.071 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3726) PolyA_pol PF01743.20 ORX68739.1 - 7.3e-17 62.0 0.1 1.4e-16 61.1 0.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ORX68739.1 - 7.5e-07 28.8 0.0 2.2e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A PHD PF00628.29 ORX68740.1 - 0.00012 21.9 3.2 0.00027 20.8 3.2 1.6 1 0 0 1 1 1 1 PHD-finger PHD_Oberon PF07227.11 ORX68740.1 - 0.0095 15.8 2.4 0.019 14.8 2.4 1.5 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein Peptidase_M16_M PF16187.5 ORX68741.1 - 6.5e-76 255.3 0.0 1.2e-75 254.4 0.0 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ORX68741.1 - 1.9e-31 109.0 0.4 4.9e-22 78.5 0.1 2.7 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX68741.1 - 9.8e-26 90.9 0.0 3.4e-13 50.0 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Phage_int_SAM_4 PF13495.6 ORX68741.1 - 0.0065 16.9 0.8 0.033 14.6 0.3 2.4 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain HU-HIG PF18291.1 ORX68741.1 - 0.093 12.8 0.2 9 6.4 0.0 2.5 2 0 0 2 2 2 0 HU domain fused to wHTH, Ig, or Glycine-rich motif SPRY PF00622.28 ORX68742.1 - 1.6e-24 86.3 0.3 2.5e-24 85.7 0.3 1.3 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 ORX68742.1 - 9.4e-15 54.8 0.0 1.4e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Spt20 PF12090.8 ORX68743.1 - 0.0098 15.5 6.2 0.013 15.1 6.2 1.2 1 0 0 1 1 1 1 Spt20 family UPF0561 PF10573.9 ORX68743.1 - 0.021 14.9 3.9 0.031 14.4 3.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 SRP14 PF02290.15 ORX68743.1 - 0.086 13.2 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle 14kD protein Androgen_recep PF02166.16 ORX68743.1 - 0.26 10.1 5.2 0.27 10.0 5.2 1.1 1 0 0 1 1 1 0 Androgen receptor Hydin_ADK PF17213.3 ORX68743.1 - 0.75 10.0 4.2 0.43 10.8 2.2 1.6 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 ORX68743.1 - 3.8 6.2 4.8 3.9 6.2 4.8 1.1 1 0 0 1 1 1 0 Presenilin DEAD PF00270.29 ORX68744.1 - 7.1e-32 110.6 0.0 1.8e-31 109.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX68744.1 - 3.8e-23 81.9 0.0 8.2e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ORX68744.1 - 4.5 6.6 5.4 4.9 6.4 0.0 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DAP PF15228.6 ORX68745.1 - 0.001 20.2 7.3 0.011 16.9 7.1 2.0 1 1 1 2 2 2 1 Death-associated protein DivIC PF04977.15 ORX68745.1 - 0.013 15.2 2.7 0.021 14.6 2.7 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF2967 PF11179.8 ORX68745.1 - 0.27 9.3 5.4 0.32 9.1 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) zf-UBP_var PF17807.1 ORX68746.1 - 1.1e-26 92.4 2.4 2.3e-24 84.9 0.3 2.7 2 0 0 2 2 2 2 Variant UBP zinc finger UBA PF00627.31 ORX68746.1 - 1.4e-22 79.2 0.5 8e-10 38.4 0.0 3.2 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.19 ORX68746.1 - 1.2e-21 76.7 18.7 4.3e-20 71.8 2.7 3.7 4 0 0 4 4 4 2 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 ORX68746.1 - 1.9e-21 76.7 0.0 3.8e-21 75.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX68746.1 - 3e-12 46.8 0.0 1.1e-05 25.2 0.0 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UBA_3 PF09288.10 ORX68746.1 - 0.0022 17.8 0.0 3.2 7.6 0.0 2.5 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain HOIP-UBA PF16678.5 ORX68746.1 - 0.039 14.0 0.0 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 HOIP UBA domain pair FYVE_2 PF02318.16 ORX68746.1 - 7.9 6.7 6.6 35 4.6 0.7 3.6 3 0 0 3 3 3 0 FYVE-type zinc finger PIN_4 PF13638.6 ORX68747.1 - 3.5e-06 27.3 0.0 8.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 PIN domain CLIP_SPH_mas PF18398.1 ORX68747.1 - 0.46 10.9 2.4 0.97 9.9 0.1 2.8 3 0 0 3 3 3 0 Clip-domain serine protease homolog masquerade DUF3498 PF12004.8 ORX68747.1 - 0.53 9.4 2.0 0.34 10.0 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3498) COesterase PF00135.28 ORX68748.1 - 2.9e-08 33.1 0.0 7.9e-08 31.6 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX68748.1 - 0.00047 20.1 0.0 0.0018 18.2 0.0 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX68748.1 - 0.01 15.4 0.0 0.031 13.7 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Sacchrp_dh_C PF16653.5 ORX68749.1 - 6.9e-75 252.6 0.0 1.3e-74 251.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.15 ORX68749.1 - 3.8e-27 95.2 0.0 1.1e-26 93.7 0.0 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.18 ORX68749.1 - 1.1e-20 74.2 0.0 2.2e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ORX68749.1 - 6.2e-07 29.6 0.0 1.9e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 ORX68749.1 - 3.6e-06 26.4 0.0 0.00071 18.9 0.0 3.3 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_3 PF03447.16 ORX68749.1 - 8.1e-05 23.3 0.0 0.013 16.1 0.0 2.6 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ORX68749.1 - 0.0035 17.3 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ORX68749.1 - 0.017 15.6 0.0 0.19 12.2 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ORX68749.1 - 0.15 12.9 0.0 0.41 11.5 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ABC_membrane PF00664.23 ORX68750.1 - 1.8e-110 368.9 31.0 4.3e-70 236.5 11.5 2.8 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX68750.1 - 8.1e-68 227.2 0.9 6e-34 117.5 0.0 2.9 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ORX68750.1 - 7.3e-14 51.7 0.0 1.5e-05 24.6 0.0 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ORX68750.1 - 1.2e-06 27.6 0.1 0.0044 15.9 0.0 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 ORX68750.1 - 1.3e-05 24.8 0.6 0.16 11.7 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX68750.1 - 2.3e-05 24.7 4.0 0.64 10.3 0.2 4.7 4 1 0 4 4 4 2 AAA domain AAA PF00004.29 ORX68750.1 - 0.00053 20.4 0.4 1.7 9.1 0.0 3.9 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 ORX68750.1 - 0.00057 19.1 0.0 0.36 10.0 0.0 2.6 2 1 0 2 2 2 2 G-protein alpha subunit SbcCD_C PF13558.6 ORX68750.1 - 0.00091 19.4 3.5 0.24 11.7 0.2 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 ORX68750.1 - 0.00097 19.1 0.2 1.9 8.4 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX68750.1 - 0.0045 17.4 8.4 0.73 10.2 0.2 3.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_24 PF13479.6 ORX68750.1 - 0.0064 16.2 0.1 4.6 6.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 ORX68750.1 - 0.0094 15.7 0.0 0.19 11.4 0.0 2.8 3 1 0 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX68750.1 - 0.0098 15.9 0.6 5.3 7.0 0.0 3.5 5 0 0 5 5 3 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX68750.1 - 0.015 14.8 0.1 3.5 7.1 0.0 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 ORX68750.1 - 0.016 14.4 0.0 2.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 ORX68750.1 - 0.022 14.1 1.1 3.2 7.0 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin DUF87 PF01935.17 ORX68750.1 - 0.058 13.5 10.5 2.2 8.3 0.2 4.2 5 0 0 5 5 4 0 Helicase HerA, central domain AAA_30 PF13604.6 ORX68750.1 - 0.071 12.8 11.1 1.6 8.4 2.0 4.1 3 2 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ORX68750.1 - 0.084 13.0 0.1 19 5.4 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX68750.1 - 0.11 12.3 0.3 40 3.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 ORX68750.1 - 0.14 12.1 0.0 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_28 PF13521.6 ORX68750.1 - 0.15 12.3 0.3 33 4.7 0.1 3.3 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ORX68750.1 - 0.15 12.4 0.0 20 5.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 ORX68750.1 - 0.22 11.1 2.3 8.9 5.8 0.2 2.9 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 ORX68750.1 - 0.25 11.9 1.0 25 5.4 0.0 3.1 3 0 0 3 3 2 0 AAA domain ECH_2 PF16113.5 ORX68750.1 - 1 8.8 8.7 7.2 6.0 0.0 3.3 2 1 0 2 2 2 0 Enoyl-CoA hydratase/isomerase NACHT PF05729.12 ORX68750.1 - 4.9 7.0 7.1 34 4.3 0.0 3.8 3 1 0 3 3 3 0 NACHT domain AAA_23 PF13476.6 ORX68750.1 - 9.7 6.6 7.6 37 4.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain Nramp PF01566.18 ORX68751.1 - 2.1e-102 342.8 15.3 3.3e-102 342.1 15.3 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein RRM_1 PF00076.22 ORX68751.1 - 3.6e-18 65.1 0.0 0.00023 20.9 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX68751.1 - 0.0033 17.0 0.1 0.69 9.5 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Corona_nucleoca PF00937.18 ORX68751.1 - 3 6.8 13.9 2.4 7.1 4.7 2.2 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein TP2 PF01254.18 ORX68751.1 - 8.1 7.1 13.9 8 7.1 4.1 2.4 2 0 0 2 2 2 0 Nuclear transition protein 2 TMEM135_C_rich PF15982.5 ORX68753.1 - 9.1e-10 39.3 0.4 1.4e-09 38.6 0.4 1.3 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.19 ORX68753.1 - 0.15 12.4 0.5 0.4 11.1 0.2 1.9 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Methyltransf_10 PF05971.12 ORX68754.1 - 1.3e-61 208.5 0.0 1.8e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_31 PF13847.6 ORX68754.1 - 0.00065 19.5 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX68754.1 - 0.00086 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX68754.1 - 0.00087 18.9 0.0 0.0019 17.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX68754.1 - 0.0045 17.7 0.0 0.014 16.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX68754.1 - 0.0091 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX68754.1 - 0.071 13.8 0.0 0.45 11.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 ORX68754.1 - 0.085 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DEAD PF00270.29 ORX68755.1 - 6.4e-40 136.8 0.3 1.1e-39 136.0 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX68755.1 - 4.2e-30 104.3 0.1 2.6e-28 98.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX68755.1 - 0.00024 21.2 1.2 0.00041 20.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CDC45 PF02724.14 ORX68755.1 - 0.00057 18.3 1.0 0.00081 17.8 1.0 1.2 1 0 0 1 1 1 1 CDC45-like protein BSP_II PF05432.11 ORX68755.1 - 0.00066 19.5 7.0 0.001 18.9 7.0 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) RNA_pol_Rpc4 PF05132.14 ORX68755.1 - 0.14 12.5 4.6 0.33 11.4 4.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_polI_A34 PF08208.11 ORX68755.1 - 0.62 10.1 15.5 1.6 8.8 15.5 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TFIIF_alpha PF05793.12 ORX68755.1 - 0.64 8.6 18.4 1.1 7.8 18.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Vfa1 PF08432.10 ORX68755.1 - 3.7 7.9 12.6 0.41 11.0 7.5 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.13 ORX68755.1 - 6.9 5.3 11.1 5.6 5.7 0.8 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 GAGA_bind PF06217.12 ORX68755.1 - 9.2 6.5 10.0 0.33 11.2 0.7 2.5 2 1 0 2 2 2 0 GAGA binding protein-like family PPR PF01535.20 ORX68756.1 - 2.4e-11 43.1 1.7 0.05 13.9 0.0 7.3 6 1 1 7 7 7 2 PPR repeat Complex1_LYR PF05347.15 ORX68756.1 - 6.4e-11 42.1 0.0 1.9e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 Complex 1 protein (LYR family) PPR_2 PF13041.6 ORX68756.1 - 8.1e-09 35.5 0.2 1.6 9.0 0.0 6.6 6 1 0 6 6 6 3 PPR repeat family PPR_long PF17177.4 ORX68756.1 - 0.00025 20.5 0.0 0.033 13.6 0.0 3.5 3 2 2 5 5 5 2 Pentacotripeptide-repeat region of PRORP Complex1_LYR_2 PF13233.6 ORX68756.1 - 0.029 15.1 0.0 0.098 13.4 0.0 1.9 2 0 0 2 2 2 0 Complex1_LYR-like TPR_19 PF14559.6 ORX68756.1 - 0.037 14.5 0.0 0.14 12.7 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Complex1_LYR_1 PF13232.6 ORX68756.1 - 0.044 14.4 0.0 0.17 12.5 0.0 2.0 2 0 0 2 2 2 0 Complex1_LYR-like ATP13 PF12921.7 ORX68756.1 - 0.15 11.9 0.1 11 5.9 0.0 3.0 2 1 2 4 4 4 0 Mitochondrial ATPase expression Actin PF00022.19 ORX68757.1 - 1.2e-20 73.5 0.0 2e-16 59.6 0.0 3.7 2 2 0 2 2 2 2 Actin Actin_micro PF17003.5 ORX68757.1 - 7.6e-11 41.8 1.5 2.1e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 ORX68757.1 - 0.00074 18.4 0.0 0.0051 15.7 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 ORX68757.1 - 0.062 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Cell division protein FtsA DUF3381 PF11861.8 ORX68757.1 - 0.27 11.0 2.3 0.44 10.3 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) COPI_assoc PF08507.10 ORX68758.1 - 2.9e-09 37.1 2.8 4.3e-09 36.5 2.8 1.2 1 0 0 1 1 1 1 COPI associated protein MARVEL PF01284.23 ORX68758.1 - 0.053 13.5 1.2 0.074 13.1 1.2 1.2 1 0 0 1 1 1 0 Membrane-associating domain Glyco_hydro_15 PF00723.21 ORX68759.1 - 1.6e-50 172.3 3.1 1.9e-50 171.9 3.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF5530 PF17670.1 ORX68759.1 - 0.099 12.4 0.1 13 5.5 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5530) Glyco_hydro_15 PF00723.21 ORX68760.1 - 7.6e-42 143.6 0.2 1.1e-41 143.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Surp PF01805.20 ORX68761.1 - 1.8e-13 50.2 0.2 1.4e-06 28.2 0.1 2.5 2 0 0 2 2 2 2 Surp module DRY_EERY PF09750.9 ORX68761.1 - 0.00043 20.6 0.5 0.0012 19.1 0.5 1.8 1 0 0 1 1 1 1 Alternative splicing regulator NUDE_C PF04880.13 ORX68762.1 - 5.7e-08 33.4 7.4 5.7e-08 33.4 7.4 2.6 2 1 0 2 2 1 1 NUDE protein, C-terminal conserved region DUF2353 PF09789.9 ORX68762.1 - 0.00021 20.8 22.6 0.0031 16.9 11.6 2.3 1 1 1 2 2 2 2 Uncharacterized coiled-coil protein (DUF2353) Flg_hook PF02120.16 ORX68762.1 - 0.032 14.1 0.9 11 6.0 0.2 2.9 2 1 0 2 2 2 0 Flagellar hook-length control protein FliK CCDC92 PF14916.6 ORX68762.1 - 0.052 13.3 5.0 2.4 8.0 0.1 3.6 3 0 0 3 3 3 0 Coiled-coil domain of unknown function Spc7 PF08317.11 ORX68762.1 - 0.071 12.0 22.5 0.49 9.2 7.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ORX68762.1 - 0.096 13.1 11.9 2.4 8.6 0.3 5.2 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) ATG16 PF08614.11 ORX68762.1 - 0.27 11.4 33.1 0.21 11.8 14.1 3.1 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.12 ORX68762.1 - 0.28 11.1 9.4 5.3 7.1 0.0 4.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Fez1 PF06818.15 ORX68762.1 - 0.34 11.3 24.0 19 5.7 24.0 2.5 1 1 0 1 1 1 0 Fez1 E2R135 PF11570.8 ORX68762.1 - 0.41 10.9 7.5 2.1 8.6 0.1 3.1 1 1 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 LMBR1 PF04791.16 ORX68762.1 - 0.94 8.3 7.5 1.3 7.9 7.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 ORX68762.1 - 1.2 9.8 15.9 24 5.6 3.5 4.0 1 1 2 4 4 4 0 Initiation control protein YabA ADIP PF11559.8 ORX68762.1 - 2.7 8.1 21.6 4.6 7.3 5.9 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 ORX68762.1 - 3.4 6.7 20.4 2.5 7.1 17.7 2.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 ORX68762.1 - 3.8 7.6 31.6 0.18 11.9 16.1 3.8 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 ORX68762.1 - 6.8 6.7 25.9 0.99 9.5 9.0 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus BCAS2 PF05700.11 ORX68763.1 - 6.7e-62 208.8 3.0 7.6e-62 208.7 3.0 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) YqzH PF14164.6 ORX68763.1 - 0.097 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 YqzH-like protein Fcf1 PF04900.12 ORX68764.1 - 1.4e-24 86.3 0.1 4.2e-24 84.8 0.0 1.8 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 ORX68764.1 - 0.0036 17.6 0.9 0.016 15.5 0.2 2.2 2 1 1 3 3 3 2 PIN like domain Methyltransf_31 PF13847.6 ORX68765.1 - 5.1e-11 42.6 0.0 9.5e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX68765.1 - 2.9e-10 40.0 0.0 5.3e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX68765.1 - 1.8e-08 35.0 0.0 4.2e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX68765.1 - 2e-07 30.7 0.0 3.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ORX68765.1 - 1.3e-06 28.4 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_10 PF05971.12 ORX68765.1 - 5.1e-05 22.8 0.0 8.3e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase Cons_hypoth95 PF03602.15 ORX68765.1 - 0.00019 21.1 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 ORX68765.1 - 0.00022 21.9 0.0 0.00049 20.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PseudoU_synth_2 PF00849.22 ORX68765.1 - 0.001 19.2 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Methyltransf_11 PF08241.12 ORX68765.1 - 0.0011 19.5 0.0 0.0034 18.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 ORX68765.1 - 0.0083 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase UPF0020 PF01170.18 ORX68765.1 - 0.0097 15.6 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_16 PF10294.9 ORX68765.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 ORX68765.1 - 0.03 14.1 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 ORX68765.1 - 0.076 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FHA PF00498.26 ORX68766.1 - 4.7e-10 39.7 0.1 2.1e-09 37.6 0.1 2.0 1 1 0 1 1 1 1 FHA domain OCRE PF17780.1 ORX68766.1 - 0.049 13.7 0.5 0.049 13.7 0.5 2.1 2 1 0 2 2 2 0 OCRE domain HhH-GPD PF00730.25 ORX68767.1 - 1.6e-14 54.3 0.0 2e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF4500 PF14937.6 ORX68768.1 - 5.8e-05 23.0 0.0 6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) Aminotran_1_2 PF00155.21 ORX68770.1 - 3e-18 66.1 0.0 1.5e-16 60.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II RRM_1 PF00076.22 ORX68771.1 - 1e-18 66.9 0.0 2.7e-18 65.5 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 ORX68771.1 - 2.7e-09 36.5 4.6 2.7e-09 36.5 4.6 2.4 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 ORX68771.1 - 5.9e-07 29.8 2.0 3.8e-06 27.3 0.0 2.3 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_7 PF16367.5 ORX68771.1 - 0.025 14.7 0.1 0.13 12.4 0.0 2.2 3 0 0 3 3 3 0 RNA recognition motif Pro_isomerase PF00160.21 ORX68772.1 - 1.4e-51 174.9 0.0 1.6e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 ORX68772.1 - 0.091 12.4 0.0 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) UCH PF00443.29 ORX68773.1 - 1.4e-68 231.2 0.0 2.4e-68 230.4 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ORX68773.1 - 3.5e-09 37.1 0.0 7.9e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ORX68773.1 - 9.5e-08 32.0 0.0 0.35 10.4 0.0 3.4 3 1 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase CENP-T_C PF15511.6 ORX68774.1 - 2.6e-08 33.9 0.1 3.2e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX68774.1 - 5.9e-05 23.1 0.1 8.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ORX68774.1 - 9.7e-05 22.7 0.1 0.00013 22.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ORX68774.1 - 0.0002 21.7 0.2 0.00023 21.6 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX68774.1 - 0.00035 20.8 0.1 0.00068 19.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX68774.1 - 0.02 14.9 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX68774.1 - 0.059 13.4 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 ORX68774.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 ORX68775.1 - 1.1e-49 168.1 1.1 1.3e-49 167.9 1.1 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX68775.1 - 0.00013 22.1 0.0 0.00024 21.2 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ORX68775.1 - 0.0002 22.0 1.4 0.00025 21.7 1.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 ORX68775.1 - 0.00049 20.4 0.0 0.00074 19.9 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 ORX68775.1 - 0.049 13.9 0.0 0.094 13.0 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YjfB_motility PF14070.6 ORX68776.1 - 0.079 13.1 4.6 0.24 11.6 3.1 2.2 2 0 0 2 2 2 0 Putative motility protein ABC_tran PF00005.27 ORX68777.1 - 7.6e-29 101.0 0.0 1.5e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68777.1 - 2.6e-05 23.8 0.0 0.00051 19.5 0.0 2.0 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX68777.1 - 0.0041 17.2 0.1 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ORX68778.1 - 1.2e-16 61.4 0.0 4.3e-16 59.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX68778.1 - 3e-08 33.4 0.0 0.0028 17.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 ORX68778.1 - 0.0025 17.9 0.1 0.0037 17.3 0.1 1.3 1 0 0 1 1 1 1 Dynamin family AAA_29 PF13555.6 ORX68778.1 - 0.0029 17.3 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX68778.1 - 0.01 15.9 0.1 0.024 14.7 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX68778.1 - 0.036 13.9 0.8 0.51 10.1 0.2 2.0 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 ORX68778.1 - 0.037 13.2 0.0 0.14 11.3 0.0 1.8 1 1 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 ORX68778.1 - 0.039 14.3 0.0 0.065 13.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ORX68778.1 - 0.088 12.7 0.2 0.16 11.9 0.2 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 ORX68778.1 - 0.16 12.5 0.0 0.19 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain GvpL_GvpF PF06386.11 ORX68782.1 - 0.15 11.9 0.4 0.2 11.5 0.4 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Asn_synthase PF00733.21 ORX68783.1 - 2.3e-17 63.7 0.4 5.7e-06 26.2 0.1 3.1 2 1 1 3 3 3 3 Asparagine synthase Ribosomal_L23eN PF03939.13 ORX68784.1 - 1.4e-17 63.6 0.5 2.7e-17 62.7 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ORX68784.1 - 3.1e-15 56.3 4.6 1.5e-14 54.1 1.0 2.6 2 1 0 2 2 2 1 Ribosomal protein L23 Tap-RNA_bind PF09162.10 ORX68784.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Tap, RNA-binding ThiF PF00899.21 ORX68785.1 - 6.1e-23 81.4 0.0 8.2e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 ORX68785.1 - 0.053 14.0 0.0 0.095 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Histone PF00125.24 ORX68786.1 - 4e-33 114.6 4.0 1.4e-32 112.8 1.0 1.9 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 PAF PF15715.5 ORX68786.1 - 9.2e-05 23.0 0.8 9.5e-05 23.0 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 ORX68787.1 - 2.6e-08 33.9 0.1 3.2e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX68787.1 - 5.9e-05 23.1 0.1 8.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ORX68787.1 - 9.7e-05 22.7 0.1 0.00013 22.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ORX68787.1 - 0.0002 21.7 0.2 0.00023 21.6 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX68787.1 - 0.00035 20.8 0.1 0.00068 19.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX68787.1 - 0.02 14.9 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX68787.1 - 0.059 13.4 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 ORX68787.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A adh_short_C2 PF13561.6 ORX68788.1 - 8.1e-38 130.3 0.5 7.9e-30 104.1 0.3 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX68788.1 - 8.1e-30 103.7 0.8 2.4e-15 56.5 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 ORX68788.1 - 1.5e-05 25.0 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Pyr_redox PF00070.27 ORX68788.1 - 0.023 15.3 0.7 0.043 14.4 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GCV_H PF01597.19 ORX68789.1 - 1.1e-39 135.1 3.1 1.2e-39 134.9 3.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 ORX68789.1 - 0.0013 18.5 0.6 0.0023 17.7 0.6 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 ORX68789.1 - 0.042 13.8 0.3 0.05 13.6 0.3 1.2 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Phage_sheath_1N PF17481.2 ORX68789.1 - 0.34 11.4 3.4 0.59 10.6 3.4 1.4 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain DNA_pol_B PF00136.21 ORX68792.1 - 7.4e-109 364.5 0.0 6.4e-108 361.4 0.0 2.0 1 1 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 ORX68792.1 - 4.9e-30 104.6 1.2 1.7e-29 102.9 1.2 1.9 1 1 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 ORX68792.1 - 4.4e-27 95.1 0.0 7.6e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 ORX68792.1 - 3.2e-12 46.3 2.5 7.8e-12 45.1 2.5 1.6 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal Hormone_6 PF00236.18 ORX68792.1 - 0.0069 16.3 0.9 5.9 7.0 0.9 2.6 2 0 0 2 2 2 2 Glycoprotein hormone DNA_pol_B_2 PF03175.13 ORX68792.1 - 0.015 14.2 0.0 0.03 13.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 ORX68792.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Velvet PF11754.8 ORX68793.1 - 1.2e-39 136.8 0.0 2e-19 70.6 0.0 2.4 1 1 1 2 2 2 2 Velvet factor GSH_synth_ATP PF03917.17 ORX68794.1 - 6.8e-123 410.1 0.0 7.9e-123 409.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ORX68794.1 - 4.1e-34 117.1 0.0 6.7e-34 116.4 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase PPR PF01535.20 ORX68795.1 - 2.4e-17 61.9 0.0 0.028 14.7 0.0 6.0 5 0 0 5 5 5 4 PPR repeat PPR_2 PF13041.6 ORX68795.1 - 8.6e-16 57.9 0.1 0.012 15.8 0.0 6.1 6 0 0 6 6 6 4 PPR repeat family PPR_1 PF12854.7 ORX68795.1 - 1.4e-13 50.3 0.0 0.029 14.1 0.0 5.4 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ORX68795.1 - 2.9e-06 27.2 0.0 0.31 11.1 0.0 4.3 5 0 0 5 5 5 2 Pentatricopeptide repeat domain TPR_14 PF13428.6 ORX68795.1 - 0.00011 22.7 1.4 2 9.5 0.2 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX68795.1 - 0.013 16.0 0.0 4.3 7.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_long PF17177.4 ORX68795.1 - 0.034 13.5 0.1 0.69 9.2 0.0 2.9 3 1 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP Atypical_Card PF18461.1 ORX68795.1 - 0.035 14.3 0.0 0.94 9.7 0.0 2.6 2 0 0 2 2 2 0 Atypical caspase recruitment domain TPR_6 PF13174.6 ORX68795.1 - 0.84 10.4 3.0 18 6.2 0.0 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat Carboxyl_trans PF01039.22 ORX68799.1 - 2.9e-162 540.8 0.0 3.8e-162 540.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 ORX68799.1 - 8.4e-146 487.2 0.1 6.2e-73 246.2 3.3 5.3 1 1 2 3 3 3 3 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 ORX68799.1 - 8.3e-38 130.0 0.1 5.6e-37 127.3 0.1 2.3 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_lipoyl PF00364.22 ORX68799.1 - 1.4e-13 50.5 0.0 3.5e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_carb_N PF00289.22 ORX68799.1 - 2.5e-13 50.5 0.4 1.3e-10 41.8 0.3 2.9 2 1 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX68799.1 - 6.4e-13 48.7 0.0 3.1e-12 46.5 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain ATP-grasp_3 PF02655.14 ORX68799.1 - 0.0016 18.5 0.0 0.0051 16.9 0.0 1.9 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ORX68799.1 - 0.02 14.7 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like LAL_C2 PF18603.1 ORX68799.1 - 0.066 13.4 0.3 2 8.7 0.0 3.2 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 ATP-grasp_4 PF13535.6 ORX68799.1 - 0.19 11.3 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ABC_tran_CTD PF16326.5 ORX68799.1 - 0.37 11.1 9.4 0.099 12.9 1.1 3.3 2 1 0 2 2 2 0 ABC transporter C-terminal domain RsbRD_N PF14361.6 ORX68799.1 - 3.5 8.4 8.2 4.4 8.0 4.7 2.8 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Vta1 PF04652.16 ORX68800.1 - 1.8e-45 154.5 0.7 3e-45 153.7 0.7 1.4 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 ORX68800.1 - 1.3e-15 56.8 0.2 2.9e-15 55.7 0.2 1.7 1 0 0 1 1 1 1 Vta1 C-terminal domain Ndc1_Nup PF09531.10 ORX68800.1 - 2.4 6.7 6.0 2.8 6.5 6.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UDPGP PF01704.18 ORX68801.1 - 0.052 12.2 0.1 0.089 11.4 0.1 1.3 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase Ribonuclease_T2 PF00445.18 ORX68802.1 - 1.4e-33 116.7 1.7 1.8e-33 116.3 1.7 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Hom_end_hint PF05203.16 ORX68803.1 - 1.2e-07 31.9 0.3 3.7e-05 23.8 0.0 2.0 1 1 1 2 2 2 2 Hom_end-associated Hint PT-HINT PF07591.11 ORX68803.1 - 0.016 15.5 0.0 0.018 15.3 0.0 1.1 1 0 0 1 1 1 0 Pretoxin HINT domain TcdB_toxin_midN PF12256.8 ORX68804.1 - 0.034 13.5 0.0 0.035 13.5 0.0 1.1 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region DIOX_N PF14226.6 ORX68806.1 - 8.1e-28 97.6 0.0 1.2e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ORX68806.1 - 5.5e-13 49.3 0.0 1e-12 48.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ribonuclease_T2 PF00445.18 ORX68807.1 - 1.4e-33 116.7 1.7 1.8e-33 116.3 1.7 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family PX PF00787.24 ORX68808.1 - 3.7e-23 81.7 0.9 9.1e-23 80.4 0.9 1.7 1 0 0 1 1 1 1 PX domain FAM92 PF06730.11 ORX68808.1 - 0.006 16.0 1.1 0.006 16.0 1.1 2.2 2 1 0 2 2 2 1 FAM92 protein Vps5 PF09325.10 ORX68808.1 - 0.041 13.4 15.6 0.62 9.6 3.1 3.4 3 1 0 3 3 3 0 Vps5 C terminal like Pro_sub2 PF18513.1 ORX68808.1 - 0.33 11.2 1.9 11 6.2 0.2 3.0 3 1 0 3 3 3 0 Prodomain subtilisin 2 RRN3 PF05327.11 ORX68809.1 - 7.3e-146 487.0 0.5 7.3e-146 487.0 0.5 1.6 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 AF-4 PF05110.13 ORX68809.1 - 0.11 10.5 2.0 0.16 10.1 2.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Cwf_Cwc_15 PF04889.12 ORX68809.1 - 0.69 9.6 23.1 0.27 10.9 13.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Mpp10 PF04006.12 ORX68809.1 - 3.4 6.0 14.5 0.031 12.7 5.1 1.9 2 0 0 2 2 2 0 Mpp10 protein TPR_2 PF07719.17 ORX68810.1 - 1.2e-26 90.7 1.4 1.2e-08 34.4 0.0 5.2 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX68810.1 - 3e-24 83.8 2.1 1.6e-09 37.1 0.0 5.1 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX68810.1 - 5.4e-24 83.6 1.4 6.1e-11 41.8 0.0 4.0 1 1 3 4 4 4 3 TPR repeat TPR_16 PF13432.6 ORX68810.1 - 2.8e-15 56.7 0.1 9.2e-06 26.2 0.0 3.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX68810.1 - 4e-15 54.7 2.5 3.1e-05 23.9 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX68810.1 - 5.4e-14 51.7 3.4 0.0007 20.2 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX68810.1 - 1.7e-13 50.9 0.9 3e-06 27.7 0.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX68810.1 - 1e-12 48.2 0.4 1.6e-07 31.5 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX68810.1 - 1.6e-12 46.9 1.9 0.00024 21.2 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX68810.1 - 7.2e-07 29.3 0.1 0.37 11.0 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX68810.1 - 5.1e-06 26.8 0.0 0.97 10.2 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.6 ORX68810.1 - 7.1e-05 22.4 2.9 0.00024 20.6 2.6 1.8 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 ORX68810.1 - 0.00022 21.0 0.2 13 6.1 0.0 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX68810.1 - 0.00057 19.7 0.3 0.5 10.3 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX68810.1 - 0.00079 18.5 1.7 0.033 13.1 1.1 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 ORX68810.1 - 0.0023 18.2 0.3 0.066 13.6 0.1 2.6 1 1 2 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX68810.1 - 0.0035 17.5 0.5 1.5 9.1 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 ORX68810.1 - 0.0064 15.9 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Coatomer epsilon subunit TOM20_plant PF06552.12 ORX68810.1 - 0.018 14.8 3.3 0.52 10.0 0.1 2.6 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Wzy_C_2 PF11846.8 ORX68810.1 - 0.024 14.6 0.0 2.5 8.0 0.0 2.2 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal SMBP PF16785.5 ORX68810.1 - 0.03 14.5 3.3 1.2 9.3 0.5 3.2 2 1 1 3 3 3 0 Small metal-binding protein TPR_4 PF07721.14 ORX68810.1 - 0.038 14.6 0.5 1.2 10.0 0.0 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat TerD PF02342.18 ORX68810.1 - 0.067 12.7 0.0 0.093 12.2 0.0 1.2 1 0 0 1 1 1 0 TerD domain NSF PF02071.20 ORX68810.1 - 0.069 13.9 2.2 3.5e+02 2.8 0.0 5.0 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat Sel1 PF08238.12 ORX68810.1 - 0.52 11.1 6.7 11 6.8 0.0 4.5 5 0 0 5 5 4 0 Sel1 repeat Rhodanese PF00581.20 ORX68811.1 - 7.2e-12 45.8 0.0 8.8e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_M24 PF00557.24 ORX68813.1 - 8.8e-35 120.3 0.8 6.6e-33 114.2 0.8 2.6 1 1 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ORX68813.1 - 4.2e-18 65.2 0.0 7.5e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Cytochrom_C1 PF02167.15 ORX68814.1 - 1.1e-95 319.6 0.0 1.3e-95 319.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ORX68814.1 - 0.024 15.0 0.0 0.055 13.8 0.0 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ORX68814.1 - 0.024 15.8 0.0 0.079 14.1 0.0 1.9 1 0 0 1 1 1 0 Cytochrome c Oxysterol_BP PF01237.18 ORX68815.1 - 2e-127 425.1 0.0 3.2e-127 424.4 0.0 1.3 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 ORX68815.1 - 4.2e-16 58.8 1.5 7.8e-08 32.4 0.1 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX68815.1 - 1.9e-14 54.0 0.1 1.6e-10 41.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 ORX68815.1 - 2.2e-13 50.6 2.4 4.7e-13 49.6 0.1 2.3 2 0 0 2 2 2 1 PH domain Ank_3 PF13606.6 ORX68815.1 - 2.6e-13 48.8 0.0 7.3e-05 22.9 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 ORX68815.1 - 2.4e-11 43.9 0.0 1.1e-06 29.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX68815.1 - 8.6e-11 41.8 0.2 2.5e-06 27.7 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat PH_8 PF15409.6 ORX68815.1 - 1.5e-07 31.6 0.7 4.5e-07 30.1 0.7 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ORX68815.1 - 3.6e-05 24.1 0.9 3.6e-05 24.1 0.9 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 ORX68815.1 - 0.0056 16.9 0.2 0.058 13.7 0.0 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain T2SSF PF00482.23 ORX68815.1 - 0.58 10.1 4.9 0.42 10.6 0.5 2.5 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F dCMP_cyt_deam_1 PF00383.23 ORX68817.1 - 4.3e-05 23.3 0.9 7.2e-05 22.6 0.9 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MMS19_N PF14500.6 ORX68817.1 - 0.081 12.5 0.1 4.7 6.7 0.0 2.5 2 1 1 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II MFS_1 PF07690.16 ORX68819.1 - 1.7e-07 30.5 28.5 1.7e-07 30.5 28.5 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily LSM PF01423.22 ORX68820.1 - 4.5e-15 55.1 0.1 5.7e-15 54.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX68820.1 - 0.0029 17.7 0.0 0.004 17.3 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain USP8_dimer PF08969.11 ORX68821.1 - 1.1e-12 48.2 0.0 1.4e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 USP8 dimerisation domain FANCI_HD2 PF14680.6 ORX68821.1 - 0.0045 16.3 1.2 1.2 8.4 0.4 2.2 2 0 0 2 2 2 2 FANCI helical domain 2 Glyco_hydro_63 PF03200.16 ORX68821.1 - 0.19 10.5 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain JAB PF01398.21 ORX68822.1 - 1.5e-18 66.9 0.1 2e-18 66.5 0.1 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ORX68822.1 - 8.8e-07 28.7 0.0 1.5e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain UQ_con PF00179.26 ORX68823.1 - 5.7e-19 68.2 0.0 6e-19 68.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX68823.1 - 0.1 12.9 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 RWD domain Transferase PF02458.15 ORX68824.1 - 1.1e-16 60.5 0.0 8.5e-16 57.6 0.0 2.0 1 1 0 1 1 1 1 Transferase family Velvet PF11754.8 ORX68826.1 - 0.00021 21.3 0.2 0.0052 16.7 0.0 2.0 1 1 1 2 2 2 2 Velvet factor MFS_1 PF07690.16 ORX68827.1 - 2.1e-09 36.8 18.7 3.1e-09 36.2 18.7 1.2 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 ORX68828.1 - 1.1e-05 24.6 17.8 1.3e-05 24.4 17.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX68828.1 - 0.0015 17.5 0.9 0.0015 17.5 0.9 2.0 1 1 0 2 2 2 2 Sugar (and other) transporter Peptidase_M99 PF17033.5 ORX68828.1 - 0.17 11.3 0.1 0.76 9.2 0.0 1.8 2 0 0 2 2 2 0 Carboxypeptidase controlling helical cell shape catalytic NuA4 PF09340.10 ORX68829.1 - 8.8e-25 86.4 1.3 1.4e-24 85.8 1.0 1.5 1 1 0 1 1 1 1 Histone acetyltransferase subunit NuA4 MetOD2 PF18548.1 ORX68829.1 - 0.0016 18.5 0.1 0.0026 17.8 0.1 1.3 1 0 0 1 1 1 1 Metanogen output domain 2 Glyco_transf_20 PF00982.21 ORX68830.1 - 1.6e-147 492.0 0.0 2.2e-147 491.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX68830.1 - 2.1e-25 89.2 0.0 5.1e-24 84.7 0.0 2.2 1 1 0 1 1 1 1 Trehalose-phosphatase Ribonuclease_T2 PF00445.18 ORX68831.1 - 1.6e-33 116.5 4.9 2.4e-33 115.9 4.9 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family PPP5 PF08321.12 ORX68831.1 - 0.0064 16.8 0.2 2.1 8.7 0.0 2.3 1 1 1 2 2 2 2 PPP5 TPR repeat region Hce2 PF14856.6 ORX68831.1 - 0.039 14.3 0.0 0.096 13.0 0.0 1.7 1 0 0 1 1 1 0 Pathogen effector; putative necrosis-inducing factor Pneumo_att_G PF05539.11 ORX68831.1 - 0.24 11.0 7.0 0.31 10.6 7.0 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Ribonuclease_T2 PF00445.18 ORX68832.1 - 2e-14 54.2 0.1 3.5e-09 37.2 0.0 2.2 1 1 1 2 2 2 2 Ribonuclease T2 family tRNA-synt_His PF13393.6 ORX68834.1 - 3.5e-37 128.3 0.4 1.1e-32 113.6 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase WHEP-TRS PF00458.20 ORX68834.1 - 1.2e-13 50.9 5.4 5.7e-13 48.8 5.4 2.2 1 0 0 1 1 1 1 WHEP-TRS domain HGTP_anticodon PF03129.20 ORX68834.1 - 1.4e-11 44.4 0.0 3.6e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 ORX68834.1 - 1e-05 24.8 0.0 3.5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 ORX68834.1 - 7.2e-05 22.8 0.0 0.00021 21.3 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 ORX68834.1 - 0.00023 20.8 0.1 0.00051 19.6 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs HHH_8 PF14716.6 ORX68834.1 - 0.051 14.0 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain ORF6C PF10552.9 ORX68834.1 - 0.064 13.3 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 ORF6C domain DUF2884 PF11101.8 ORX68834.1 - 0.088 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) ApoO PF09769.9 ORX68835.1 - 9.5e-10 38.5 6.1 8.7e-08 32.2 0.3 4.1 2 2 2 4 4 4 1 Apolipoprotein O KfrA_N PF11740.8 ORX68835.1 - 0.013 16.2 4.5 0.013 16.2 4.5 2.3 2 1 0 2 2 2 0 Plasmid replication region DNA-binding N-term Apolipoprotein PF01442.18 ORX68835.1 - 0.017 15.0 3.5 0.017 15.0 3.5 1.8 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain TipAS PF07739.13 ORX68835.1 - 0.14 12.7 4.9 1 9.9 2.1 2.7 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain TBCA PF02970.16 ORX68835.1 - 0.2 12.0 4.7 0.38 11.1 0.4 2.5 1 1 1 2 2 2 0 Tubulin binding cofactor A DUF883 PF05957.13 ORX68835.1 - 0.23 12.1 11.2 0.099 13.3 1.4 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) REF PF05755.12 ORX68835.1 - 0.35 10.7 5.6 0.67 9.7 5.6 1.4 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) ParB PF08775.10 ORX68835.1 - 0.38 11.2 5.1 0.36 11.3 2.7 2.1 1 1 1 2 2 2 0 ParB family DUF724 PF05266.14 ORX68835.1 - 0.39 10.5 5.7 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ApoLp-III PF07464.11 ORX68835.1 - 0.47 10.6 10.2 2.6 8.1 10.2 2.2 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF2894 PF11445.8 ORX68835.1 - 0.63 10.5 5.1 0.98 9.9 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) Phage_holin_6_1 PF09682.10 ORX68835.1 - 1.1 9.7 7.7 0.77 10.2 4.5 2.2 1 1 1 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) THDPS_N_2 PF14805.6 ORX68835.1 - 1.7 9.0 4.4 2.3 8.5 2.8 2.2 2 1 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal V-ATPase_G_2 PF16999.5 ORX68835.1 - 1.8 9.0 13.3 1 9.8 9.9 2.0 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit YtxH PF12732.7 ORX68835.1 - 5 7.7 21.1 38 4.9 13.9 3.6 3 1 0 3 3 2 0 YtxH-like protein RRF PF01765.19 ORX68835.1 - 5 7.1 11.9 22 5.0 10.0 2.5 2 1 0 2 2 2 0 Ribosome recycling factor Chlorosome_CsmC PF11098.8 ORX68835.1 - 5.7 6.9 8.6 1.4 8.9 3.0 2.5 2 1 1 3 3 3 0 Chlorosome envelope protein C Ribosomal_S8 PF00410.19 ORX68836.1 - 4.2e-22 78.4 0.0 7.6e-22 77.6 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S8 Mur_ligase_M PF08245.12 ORX68837.1 - 3.4e-08 33.7 0.1 7.1e-05 22.9 0.0 3.2 1 1 1 2 2 2 2 Mur ligase middle domain Mur_ligase_C PF02875.21 ORX68837.1 - 0.0019 18.4 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain HD_4 PF13328.6 ORX68837.1 - 0.1 12.3 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 HD domain CDC50 PF03381.15 ORX68838.1 - 7.7e-90 301.2 0.0 9.2e-90 301.0 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family ADSL_C PF10397.9 ORX68839.1 - 4.8e-18 65.5 0.0 1.1e-17 64.3 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Lyase_1 PF00206.20 ORX68839.1 - 9.9e-11 41.6 0.0 1.2e-06 28.1 0.0 2.3 2 0 0 2 2 2 2 Lyase Glucosamine_iso PF01182.20 ORX68840.1 - 2.1e-70 237.1 0.0 2.4e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Glyco_tranf_2_3 PF13641.6 ORX68840.1 - 0.061 13.2 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Tfb2 PF03849.14 ORX68843.1 - 5.6e-127 423.6 0.3 6.7e-127 423.3 0.3 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ORX68843.1 - 2.2e-23 82.4 0.7 4.5e-23 81.4 0.7 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 ORX68843.1 - 0.0012 19.0 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain E1-E2_ATPase PF00122.20 ORX68844.1 - 1.2e-43 148.8 2.5 1.2e-43 148.8 2.5 2.5 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX68844.1 - 1.2e-32 113.9 0.0 7.8e-32 111.3 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX68844.1 - 3.4e-07 30.6 0.3 7.5e-07 29.5 0.3 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ORX68844.1 - 4.1e-05 23.5 0.1 0.0071 16.1 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX68844.1 - 0.00012 22.5 0.0 0.00088 19.7 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1980 PF09323.10 ORX68844.1 - 0.14 12.1 0.4 19 5.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF1754 PF08555.10 ORX68845.1 - 4.4e-06 27.4 25.7 0.003 18.3 12.0 2.5 2 1 1 3 3 3 2 Eukaryotic family of unknown function (DUF1754) Phage_GPO PF05929.11 ORX68845.1 - 0.038 13.6 5.2 0.04 13.5 5.2 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase MM_CoA_mutase PF01642.22 ORX68845.1 - 0.53 8.8 4.6 0.56 8.7 4.6 1.0 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase Pannexin_like PF12534.8 ORX68845.1 - 0.63 9.1 9.8 0.74 8.8 9.8 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF3959 PF13105.6 ORX68845.1 - 3.7 7.0 5.2 4.7 6.6 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) RabGAP-TBC PF00566.18 ORX68846.1 - 2.2e-48 164.8 0.0 2.7e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Snf7 PF03357.21 ORX68847.1 - 3.5e-48 163.5 20.3 3.5e-48 163.5 20.3 1.6 2 0 0 2 2 2 1 Snf7 DUF2586 PF10758.9 ORX68847.1 - 0.019 14.1 1.4 0.022 14.0 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) DUF5347 PF17282.2 ORX68847.1 - 0.027 14.8 1.9 0.027 14.8 1.9 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5347) Vir_act_alpha_C PF10400.9 ORX68847.1 - 0.65 10.7 3.8 10 6.9 0.3 3.0 2 1 0 2 2 2 0 Virulence activator alpha C-term DUF4407 PF14362.6 ORX68847.1 - 1.3 8.4 9.5 1.8 7.8 9.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fe_hyd_lg_C PF02906.14 ORX68847.1 - 2.1 7.9 5.9 2 8.0 4.1 1.7 1 1 1 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Atg14 PF10186.9 ORX68847.1 - 3.8 6.5 11.3 6.2 5.8 11.3 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med9 PF07544.13 ORX68847.1 - 4.9 7.3 15.3 0.49 10.5 3.0 3.0 2 1 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 UBD PF16455.5 ORX68849.1 - 6.9e-31 106.6 0.0 1.5e-30 105.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 ORX68849.1 - 0.00085 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX68849.1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF924 PF06041.11 ORX68850.1 - 1.9e-57 194.3 1.5 2.5e-57 193.9 1.5 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) DUF2322 PF10084.9 ORX68850.1 - 0.00019 21.4 0.0 0.00046 20.2 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2322) ABC_tran PF00005.27 ORX68851.1 - 1.7e-27 96.6 0.0 2.3e-14 54.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX68851.1 - 1.7e-07 30.9 1.8 0.088 12.2 0.0 4.1 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX68851.1 - 2.3e-06 27.2 0.3 0.005 16.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX68851.1 - 4.6e-05 23.4 0.5 0.27 11.0 0.2 3.9 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX68851.1 - 0.00011 22.6 0.1 0.51 10.7 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX68851.1 - 0.00025 21.3 0.2 0.89 9.8 0.1 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ORX68851.1 - 0.0012 18.9 0.8 0.32 11.1 0.3 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX68851.1 - 0.0024 17.8 0.4 0.25 11.2 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 ORX68851.1 - 0.027 14.4 1.7 1.5 8.7 0.0 3.1 3 0 0 3 3 3 0 NACHT domain AAA_23 PF13476.6 ORX68851.1 - 0.036 14.6 0.0 3.3 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ORX68851.1 - 0.055 13.5 1.0 0.65 10.0 0.2 2.8 3 0 0 3 3 3 0 Dynamin family AAA_15 PF13175.6 ORX68851.1 - 0.35 10.5 0.0 2.7 7.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain HMGL-like PF00682.19 ORX68852.1 - 3.9e-89 298.7 0.0 5.7e-89 298.2 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 ORX68852.1 - 2.1e-23 82.7 0.4 3.5e-23 82.0 0.4 1.4 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain 7tm_3 PF00003.22 ORX68853.1 - 8.1e-08 32.3 18.5 1.3e-07 31.6 18.5 1.3 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Pribosyltran_N PF13793.6 ORX68854.1 - 8e-48 161.2 0.5 4.7e-47 158.7 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ORX68854.1 - 1.3e-45 155.7 2.8 4.1e-37 128.0 1.6 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ORX68854.1 - 5.2e-15 55.3 1.9 4.4e-13 49.0 1.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 ORX68854.1 - 0.0099 15.3 0.3 0.017 14.5 0.3 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Sel1 PF08238.12 ORX68855.1 - 2.3e-15 56.7 0.2 0.00079 20.0 0.0 4.8 4 0 0 4 4 4 4 Sel1 repeat RRN3 PF05327.11 ORX68855.1 - 0.0017 17.0 1.2 0.0021 16.7 1.2 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 ORX68855.1 - 0.039 13.0 4.5 0.057 12.5 4.5 1.1 1 0 0 1 1 1 0 Pes-10 RPN2_C PF18004.1 ORX68855.1 - 0.13 12.2 0.2 0.22 11.4 0.2 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Peptidase_A22B PF04258.13 ORX68856.1 - 8e-85 284.8 7.1 1.1e-84 284.4 7.1 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 ORX68856.1 - 2.5e-05 23.9 3.2 2.5e-05 23.9 3.2 3.0 2 1 1 3 3 3 2 Signal-peptide peptidase, presenilin aspartyl protease Trypsin PF00089.26 ORX68857.1 - 2.4e-29 102.7 0.4 2.9e-29 102.5 0.4 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX68857.1 - 0.00071 20.5 0.0 0.0011 19.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Leader_Thr PF08254.11 ORX68857.1 - 0.088 12.6 0.3 0.088 12.6 0.3 2.3 2 0 0 2 2 2 0 Threonine leader peptide DUF1729 PF08354.10 ORX68858.1 - 7.3e-134 446.1 0.0 1.2e-133 445.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX68858.1 - 4.3e-52 177.6 7.7 4.1e-51 174.4 0.1 4.3 5 0 0 5 5 5 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX68858.1 - 1.3e-47 162.2 0.0 2.2e-47 161.4 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX68858.1 - 1.2e-34 119.7 0.0 3e-34 118.4 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX68858.1 - 4.1e-24 84.5 0.0 1.1e-23 83.1 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX68858.1 - 8.8e-21 74.3 0.0 1.7e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX68858.1 - 1.5e-20 73.8 0.2 3.1e-20 72.8 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX68858.1 - 1.8e-20 73.7 0.1 5.1e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX68858.1 - 1.6e-12 47.4 0.0 4.1e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Lipase_3 PF01764.25 ORX68858.1 - 0.082 12.8 0.4 87 3.0 0.0 3.5 3 0 0 3 3 3 0 Lipase (class 3) FAS_N PF17828.1 ORX68858.1 - 0.1 12.6 1.1 0.26 11.3 0.4 2.1 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta SAT PF16073.5 ORX68859.1 - 1e-17 64.7 0.0 2.2e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Dus PF01207.17 ORX68910.1 - 6e-68 229.2 0.0 6.7e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 ORX68910.1 - 2e-06 27.2 0.0 0.00034 19.9 0.0 2.1 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 ORX68910.1 - 9.8e-06 25.2 0.0 1.8e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 ORX68910.1 - 0.00046 19.6 0.1 0.0011 18.4 0.0 1.7 2 0 0 2 2 2 1 Thiamine monophosphate synthase NMO PF03060.15 ORX68910.1 - 0.00088 18.8 0.1 0.0062 16.0 0.1 1.9 1 1 1 2 2 2 1 Nitronate monooxygenase Oxidored_FMN PF00724.20 ORX68910.1 - 0.0027 17.1 0.1 0.0087 15.4 0.1 1.7 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 ORX68910.1 - 0.072 12.5 0.0 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Cyclase PF04199.13 ORX68912.1 - 3.8e-24 85.5 0.1 5.4e-24 85.0 0.1 1.2 1 0 0 1 1 1 1 Putative cyclase Utp11 PF03998.13 ORX68913.1 - 7.9e-71 238.8 27.0 8.9e-71 238.7 27.0 1.0 1 0 0 1 1 1 1 Utp11 protein CENP-F_N PF10481.9 ORX68913.1 - 0.0035 17.0 8.8 0.26 10.9 1.6 2.3 1 1 1 2 2 2 2 Cenp-F N-terminal domain PAS_10 PF13596.6 ORX68913.1 - 0.049 14.2 0.3 0.12 12.9 0.1 1.9 2 1 0 2 2 2 0 PAS domain SLATT_5 PF18160.1 ORX68913.1 - 0.2 10.9 1.1 0.34 10.2 0.7 1.5 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Cut12 PF11500.8 ORX68913.1 - 6.1 6.8 15.2 0.055 13.4 3.9 2.4 2 1 0 2 2 2 0 Spindle pole body formation-associated protein SIP1 PF04938.12 ORX68914.1 - 8e-34 117.3 0.0 9.6e-34 117.0 0.0 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) PQ-loop PF04193.14 ORX68915.1 - 5.2e-24 83.8 5.5 3.8e-13 49.0 0.9 2.5 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 ORX68915.1 - 0.081 13.0 4.8 0.31 11.1 0.3 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Pacifastin_I PF05375.13 ORX68916.1 - 2.6e-07 30.2 11.7 2.6e-07 30.2 11.7 1.8 2 0 0 2 2 2 1 Pacifastin inhibitor (LCMII) SHQ1 PF04925.15 ORX68917.1 - 8.7e-62 207.8 3.1 1.3e-61 207.2 3.1 1.3 1 0 0 1 1 1 1 SHQ1 protein ArsA_HSP20 PF17886.1 ORX68917.1 - 0.13 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 HSP20-like domain found in ArsA IF-2B PF01008.17 ORX68918.1 - 1.2e-70 238.0 0.0 1.3e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family CcdA PF07362.12 ORX68918.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA FIST PF08495.10 ORX68919.1 - 5.7e-07 29.7 0.2 5.7e-07 29.7 0.2 1.7 2 0 0 2 2 2 1 FIST N domain Methyltransf_PK PF05891.12 ORX68920.1 - 1.7e-74 250.0 0.1 1.9e-74 249.9 0.1 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 ORX68920.1 - 4.1e-09 37.0 0.0 8e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX68920.1 - 3.3e-07 31.0 0.0 5.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX68920.1 - 1.9e-06 28.4 0.0 3.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX68920.1 - 5e-06 26.4 0.0 6.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX68920.1 - 0.00048 19.5 0.0 0.00074 18.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 ORX68920.1 - 0.0017 18.2 0.1 0.0022 17.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 ORX68920.1 - 0.054 13.0 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MTS PF05175.14 ORX68920.1 - 0.055 13.0 0.0 0.088 12.3 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase small domain LPD23 PF18838.1 ORX68920.1 - 0.41 10.5 2.0 2.9 7.7 0.3 2.7 3 0 0 3 3 3 0 Large polyvalent protein associated domain 23 IF3_N PF05198.16 ORX68921.1 - 0.088 13.1 16.4 14 6.0 0.4 6.2 4 2 2 6 6 6 0 Translation initiation factor IF-3, N-terminal domain TFIIE-A_C PF11521.8 ORX68921.1 - 2.6 8.4 22.4 1.9 8.9 0.5 4.8 3 1 2 5 5 5 0 C-terminal general transcription factor TFIIE alpha DSRB PF10781.9 ORX68921.1 - 6.8 6.4 7.1 15 5.3 0.1 5.0 7 1 1 8 8 8 0 Dextransucrase DSRB Cofilin_ADF PF00241.20 ORX68922.1 - 5.1e-25 87.6 0.0 6e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RPAP1_C PF08620.10 ORX68923.1 - 5.5e-27 93.7 0.1 1.3e-26 92.4 0.1 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 ORX68923.1 - 1.4e-09 37.5 4.5 4.4e-09 36.0 4.5 1.8 1 0 0 1 1 1 1 RPAP1-like, N-terminal TMEM171 PF15471.6 ORX68923.1 - 0.21 10.5 0.4 0.51 9.3 0.0 1.8 2 0 0 2 2 2 0 Transmembrane protein family 171 malic PF00390.19 ORX68924.1 - 3.5e-46 157.3 0.0 8e-46 156.1 0.0 1.7 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 ORX68924.1 - 4.8e-35 121.1 1.0 4e-31 108.2 1.0 4.1 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain Dimeth_Pyl PF09505.10 ORX68924.1 - 0.086 11.4 0.5 1.9 6.9 0.1 2.1 2 0 0 2 2 2 0 Dimethylamine methyltransferase (Dimeth_PyL) WD40 PF00400.32 ORX68930.1 - 3.6e-11 43.4 12.3 0.0046 17.8 0.3 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX68930.1 - 2.8e-08 33.9 0.1 0.039 14.2 0.0 5.9 4 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX68930.1 - 0.0071 16.2 0.0 0.82 9.5 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ORX68930.1 - 0.047 13.6 3.5 27 4.9 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat IKI3 PF04762.12 ORX68930.1 - 0.071 11.1 0.5 0.18 9.7 0.0 1.9 2 0 0 2 2 2 0 IKI3 family Lactonase PF10282.9 ORX68930.1 - 0.1 11.9 0.0 2.7 7.2 0.0 2.7 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Glyco_hydro_18 PF00704.28 ORX68931.1 - 1.3e-22 80.9 0.0 1.5e-22 80.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 dNK PF01712.19 ORX68931.1 - 0.23 11.3 0.0 0.36 10.7 0.0 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase Glyco_hydro_31 PF01055.26 ORX68935.1 - 2.9e-124 415.6 0.0 1.7e-123 413.1 0.0 2.1 2 1 0 2 2 2 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX68935.1 - 2.8e-29 101.6 0.0 7.5e-29 100.3 0.0 1.7 2 0 0 2 2 2 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX68935.1 - 1.7e-05 25.1 0.3 4.9e-05 23.6 0.3 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 ORX68935.1 - 0.063 13.6 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) adh_short PF00106.25 ORX68936.1 - 2e-36 125.3 0.5 3.3e-35 121.3 0.5 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX68936.1 - 5.7e-29 101.3 0.1 5.5e-28 98.1 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ORX68936.1 - 1.3e-05 24.8 0.3 4.4e-05 23.0 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ORX68936.1 - 6.9e-05 22.8 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 KR domain p450 PF00067.22 ORX68937.1 - 3.3e-63 214.0 0.0 4.5e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 N2227 PF07942.12 ORX68940.1 - 1.8e-98 329.1 0.0 2.4e-98 328.6 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 ORX68940.1 - 0.07 13.9 0.0 0.23 12.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ORX68940.1 - 0.11 12.3 0.0 0.74 9.6 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Aminotran_1_2 PF00155.21 ORX68941.1 - 6e-44 150.7 0.0 7.2e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PPR_2 PF13041.6 ORX68942.1 - 1.2e-23 83.0 0.1 3.7e-09 36.6 0.0 8.3 9 0 0 9 9 9 3 PPR repeat family PPR_3 PF13812.6 ORX68942.1 - 7.8e-15 54.7 0.0 8.8e-07 28.9 0.0 6.0 7 0 0 7 7 7 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX68942.1 - 3.5e-10 39.4 0.6 0.11 12.2 0.0 5.5 5 0 0 5 5 5 3 PPR repeat PPR PF01535.20 ORX68942.1 - 7.8e-10 38.3 7.7 0.091 13.1 0.1 7.9 8 0 0 8 8 8 2 PPR repeat PPR_long PF17177.4 ORX68942.1 - 0.00025 20.5 0.4 0.52 9.6 0.0 4.4 5 0 0 5 5 5 1 Pentacotripeptide-repeat region of PRORP ECSIT PF06239.11 ORX68942.1 - 0.14 11.3 0.0 18 4.3 0.0 2.5 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway Phage_holin_2_4 PF16082.5 ORX68944.1 - 0.00068 19.3 0.0 0.0015 18.2 0.0 1.6 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like Herpes_gE PF02480.16 ORX68944.1 - 0.034 12.9 0.1 0.085 11.6 0.0 1.5 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E CcmD PF04995.14 ORX68944.1 - 0.097 12.8 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Trypsin PF00089.26 ORX68945.1 - 7.7e-28 97.8 1.3 1e-27 97.4 1.3 1.2 1 0 0 1 1 1 1 Trypsin Podoplanin PF05808.11 ORX68945.1 - 0.00013 22.1 0.2 0.00027 21.1 0.2 1.5 1 0 0 1 1 1 1 Podoplanin RIFIN PF02009.16 ORX68945.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Rifin Syndecan PF01034.20 ORX68945.1 - 0.0092 15.9 0.3 0.017 15.0 0.3 1.4 1 0 0 1 1 1 1 Syndecan domain EphA2_TM PF14575.6 ORX68945.1 - 0.01 16.7 0.0 0.022 15.6 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 ORX68945.1 - 0.012 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TMEM154 PF15102.6 ORX68945.1 - 0.026 14.4 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family Adeno_E3_CR2 PF02439.15 ORX68945.1 - 0.026 14.3 0.4 0.058 13.2 0.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NIR_SIR PF01077.22 ORX68945.1 - 0.036 13.6 0.0 0.16 11.5 0.0 1.9 2 0 0 2 2 2 0 Nitrite and sulphite reductase 4Fe-4S domain FeoB_associated PF12669.7 ORX68945.1 - 0.037 14.4 1.1 0.037 14.4 1.1 1.8 2 0 0 2 2 1 0 FeoB-associated Cys-rich membrane protein GTP_EFTU_D2 PF03144.25 ORX68945.1 - 0.086 13.2 2.0 0.62 10.5 0.0 2.9 3 0 0 3 3 3 0 Elongation factor Tu domain 2 VSP PF03302.13 ORX68945.1 - 0.61 8.9 12.0 7.9 5.2 11.4 2.1 1 1 1 2 2 2 0 Giardia variant-specific surface protein Trypsin PF00089.26 ORX68946.1 - 1.6e-28 100.0 0.0 2.4e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin Adeno_terminal PF02459.15 ORX68947.1 - 0.11 10.8 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein p450 PF00067.22 ORX68949.1 - 4e-63 213.8 0.0 5.4e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX68950.1 - 1.7e-74 251.3 0.0 2.2e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Questin_oxidase PF14027.6 ORX68950.1 - 0.15 11.6 0.1 0.29 10.6 0.0 1.5 2 0 0 2 2 2 0 Questin oxidase-like adh_short PF00106.25 ORX68951.1 - 3.8e-33 114.6 0.2 4e-32 111.3 0.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX68951.1 - 5e-26 91.7 0.1 3.4e-25 89.0 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ORX68951.1 - 0.00047 19.7 0.2 0.0023 17.4 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ORX68951.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 KR domain Autophagy_N PF03986.13 ORX68952.1 - 1.4e-46 157.8 0.1 2.7e-46 156.9 0.1 1.4 1 1 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 ORX68952.1 - 5.3e-21 75.0 0.2 1e-20 74.1 0.2 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 ORX68952.1 - 3.4e-17 61.6 3.1 6.2e-17 60.8 3.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal ATP-synt_DE PF00401.20 ORX68954.1 - 0.13 12.6 1.2 0.78 10.1 1.2 2.4 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF3410 PF11890.8 ORX68955.1 - 0.054 13.3 0.4 0.18 11.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) Chitin_synth_1 PF01644.17 ORX68956.1 - 2.7e-75 251.8 0.1 4.2e-75 251.2 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX68956.1 - 1.1e-28 99.0 0.1 2.3e-28 97.9 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX68956.1 - 7.4e-25 87.6 2.0 1.1e-22 80.4 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX68956.1 - 1.7e-09 37.9 0.6 1.7e-09 37.9 0.6 2.0 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX68956.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 NPCC PF08058.11 ORX68956.1 - 9.2 6.3 5.7 3.2 7.8 0.0 2.7 2 1 1 3 3 3 0 Nuclear pore complex component DUF2892 PF11127.8 ORX68957.1 - 0.1 12.7 0.2 0.17 12.0 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2892) Opy2 PF09463.10 ORX68958.1 - 0.053 13.8 1.6 0.087 13.2 1.6 1.3 1 0 0 1 1 1 0 Opy2 protein DUF4448 PF14610.6 ORX68958.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3235 PF11574.8 ORX68959.1 - 3 8.8 5.2 5.8 7.9 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Bcl-2_3 PF15286.6 ORX68961.1 - 0.061 14.0 0.1 0.52 11.0 0.0 2.6 3 0 0 3 3 3 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like RhoGEF PF00621.20 ORX68962.1 - 2.1e-44 151.9 0.0 3.4e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Mito_carr PF00153.27 ORX68963.1 - 2e-73 242.4 1.3 5.2e-25 87.2 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 ORX68963.1 - 1e-06 27.9 0.0 0.3 10.8 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 ORX68963.1 - 2.9e-06 27.6 0.0 0.32 11.5 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX68963.1 - 6.6e-06 25.7 0.0 0.086 12.8 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ORX68963.1 - 0.059 12.9 0.2 1 8.9 0.0 2.9 4 0 0 4 4 4 0 EF hand EF-hand_8 PF13833.6 ORX68963.1 - 0.069 13.0 0.0 3.7 7.5 0.0 3.0 2 1 0 2 2 2 0 EF-hand domain pair Serine_protease PF18405.1 ORX68963.1 - 0.086 12.0 0.3 3.2 6.8 0.0 2.9 3 0 0 3 3 3 0 Gammaproteobacterial serine protease tRNA-synt_2 PF00152.20 ORX68963.1 - 0.098 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) LEA_2 PF03168.13 ORX68964.1 - 0.00022 21.7 0.0 0.00039 20.9 0.0 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein Trypsin_2 PF13365.6 ORX68965.1 - 1.4e-18 68.3 0.4 5.5e-16 59.8 0.0 2.8 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_1 PF12812.7 ORX68965.1 - 5.4e-16 58.4 0.0 9.9e-10 38.3 0.0 3.5 3 0 0 3 3 3 2 PDZ-like domain PDZ_6 PF17820.1 ORX68965.1 - 1.9e-11 43.6 6.5 0.0069 16.2 0.0 4.9 4 1 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 ORX68965.1 - 2.2e-11 43.9 0.2 0.00012 22.3 0.0 4.0 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 ORX68965.1 - 2.8e-10 40.4 2.2 0.00016 21.9 0.0 4.3 4 1 0 4 4 4 2 PDZ domain Tricorn_PDZ PF14685.6 ORX68965.1 - 1.2e-05 25.2 0.4 0.0064 16.4 0.1 3.0 3 0 0 3 3 3 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 ORX68965.1 - 0.03 14.7 0.3 2.7 8.4 0.1 2.9 3 0 0 3 3 3 0 PDZ domain p450 PF00067.22 ORX68966.1 - 6.1e-47 160.4 0.1 1.6e-43 149.1 0.1 3.9 1 1 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 ORX68966.1 - 2.8e-19 69.7 0.0 6.7e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 ORX68966.1 - 3.3e-10 39.9 0.0 6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ORX68966.1 - 5.8e-10 39.8 0.0 3.2e-09 37.4 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain AMP-binding PF00501.28 ORX68967.1 - 7.2e-96 321.3 0.0 9.1e-96 321.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX68967.1 - 1.7e-14 54.6 0.3 5.5e-14 52.9 0.0 2.0 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Oxidored-like PF09791.9 ORX68969.1 - 1.6e-15 56.5 3.5 2.7e-15 55.8 3.5 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal CAT PF00302.18 ORX68969.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase Peptidase_M50B PF13398.6 ORX68970.1 - 2.9e-57 193.6 14.9 3.6e-57 193.3 14.9 1.1 1 0 0 1 1 1 1 Peptidase M50B-like DUF3278 PF11683.8 ORX68970.1 - 0.12 12.5 1.0 0.46 10.6 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3278) THOC2_N PF16134.5 ORX68971.1 - 1.5e-70 238.6 5.8 7.4e-68 229.7 0.0 3.7 4 0 0 4 4 4 2 THO complex subunit 2 N-terminus Tho2 PF11262.8 ORX68971.1 - 3.6e-60 203.7 1.0 3.6e-60 203.7 1.0 2.1 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 ORX68971.1 - 1.7e-20 72.8 0.0 4.4e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Glyco_hydro_31 PF01055.26 ORX68972.1 - 1.9e-157 525.0 0.7 1.9e-157 525.0 0.7 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX68972.1 - 2.3e-30 105.2 0.0 4.2e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX68972.1 - 2.6e-06 27.7 0.2 6.8e-06 26.3 0.2 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 ORX68972.1 - 0.0094 16.2 0.3 0.045 14.0 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) Aminotran_1_2 PF00155.21 ORX68974.1 - 0.00076 18.8 0.0 0.00086 18.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Maf1 PF09174.10 ORX68975.1 - 1.5e-60 204.3 0.1 1.8e-60 204.1 0.1 1.1 1 0 0 1 1 1 1 Maf1 regulator RXT2_N PF08595.11 ORX68976.1 - 3.9e-05 23.7 0.9 0.00013 22.0 0.0 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal Cep57_MT_bd PF06657.13 ORX68976.1 - 0.015 15.7 1.2 0.12 12.8 1.0 2.5 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Pup PF05639.11 ORX68976.1 - 0.057 14.3 0.8 0.77 10.7 0.0 2.6 2 0 0 2 2 2 0 Pup-like protein Peptidase_M28 PF04389.17 ORX68979.1 - 3.3e-12 46.5 0.0 2.8e-08 33.7 0.0 2.3 1 1 1 2 2 2 2 Peptidase family M28 PA PF02225.22 ORX68979.1 - 0.00021 21.3 0.3 0.00042 20.3 0.3 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX68979.1 - 0.02 14.6 0.0 0.095 12.4 0.0 1.9 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 ER_lumen_recept PF00810.18 ORX68980.1 - 2.3e-43 148.6 10.7 2.9e-31 109.3 1.2 2.3 1 1 1 2 2 2 2 ER lumen protein retaining receptor PQ-loop PF04193.14 ORX68980.1 - 0.0011 18.6 6.5 0.091 12.6 0.3 3.0 3 0 0 3 3 3 2 PQ loop repeat zf-H2C2_2 PF13465.6 ORX68981.1 - 4.3e-30 102.8 44.8 1.6e-09 37.7 1.0 7.9 9 0 0 9 9 8 5 Zinc-finger double domain zf-C2H2 PF00096.26 ORX68981.1 - 6.6e-24 83.0 51.8 3.1e-05 24.2 0.6 9.3 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX68981.1 - 1.1e-14 53.8 51.5 0.0052 17.5 0.5 9.4 9 0 0 9 9 9 7 C2H2-type zinc finger FOXP-CC PF16159.5 ORX68981.1 - 5.8e-12 46.1 24.7 0.0019 18.8 0.0 6.8 3 2 4 7 7 7 4 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX68981.1 - 2.4e-08 34.1 10.3 0.2 12.0 0.5 6.3 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf_ZIC PF18366.1 ORX68981.1 - 1.3e-05 25.2 0.4 0.00035 20.6 0.1 7.6 9 1 0 9 9 9 2 Zic proteins zinc finger domain zf-met PF12874.7 ORX68981.1 - 1.8e-05 25.0 8.9 0.064 13.7 0.0 4.4 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 ORX68981.1 - 2.6e-05 24.5 22.0 0.19 12.1 4.2 5.0 1 1 4 5 5 5 4 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 ORX68981.1 - 0.02 14.7 0.2 0.02 14.7 0.2 7.8 9 0 0 9 9 9 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.5 ORX68981.1 - 0.023 14.9 17.5 2.3 8.4 0.4 5.3 1 1 5 6 6 6 0 Aberrant zinc-finger Zap1_zf2 PF18217.1 ORX68981.1 - 0.023 14.7 1.1 0.023 14.7 1.1 3.9 4 0 0 4 4 4 0 Zap1 zinc finger 2 zf-C2H2_3rep PF18868.1 ORX68981.1 - 0.099 13.3 17.5 0.064 13.9 1.7 4.6 1 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2HC_2 PF13913.6 ORX68981.1 - 1.7 8.7 16.0 16 5.5 0.2 6.0 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 ORX68981.1 - 3.1 7.9 34.0 0.52 10.4 1.0 7.8 8 0 0 8 8 8 0 C2H2-type zinc finger DUF2180 PF09947.9 ORX68981.1 - 8 6.5 9.1 0.24 11.4 0.7 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) Cmc1 PF08583.10 ORX68982.1 - 3.1e-14 52.8 1.3 4.3e-14 52.3 1.3 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like TMIE PF16038.5 ORX68982.1 - 0.021 14.6 0.4 0.025 14.4 0.4 1.2 1 0 0 1 1 1 0 TMIE protein Cytadhesin_P30 PF07271.11 ORX68982.1 - 0.23 11.0 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 ETF PF01012.21 ORX68983.1 - 2.9e-50 170.7 3.9 3.9e-50 170.3 3.9 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Methyltr_RsmB-F PF01189.17 ORX68984.1 - 2.9e-38 131.5 0.0 5.2e-37 127.4 0.0 2.2 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ORX68984.1 - 0.021 15.0 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase HHH_3 PF12836.7 ORX68984.1 - 0.11 12.7 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Zip PF02535.22 ORX68984.1 - 0.47 9.6 1.5 0.35 10.1 0.1 1.4 2 0 0 2 2 2 0 ZIP Zinc transporter AAA_11 PF13086.6 ORX68984.1 - 0.77 9.5 8.0 0.037 13.8 2.3 1.6 2 0 0 2 2 2 0 AAA domain RNA_pol_Rpc4 PF05132.14 ORX68984.1 - 0.8 10.1 6.6 1.5 9.2 2.8 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 CDC45 PF02724.14 ORX68984.1 - 2 6.6 7.7 3.7 5.7 7.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ORX68984.1 - 9.4 6.5 14.4 0.25 11.6 6.9 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Ras PF00071.22 ORX68985.1 - 3.5e-59 199.0 0.6 4.5e-59 198.7 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX68985.1 - 1.4e-36 125.4 0.1 2.3e-36 124.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX68985.1 - 1.7e-16 60.1 0.5 2e-16 59.9 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX68985.1 - 1e-06 28.4 0.2 3.5e-06 26.7 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX68985.1 - 4.9e-06 26.1 0.1 7e-06 25.6 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX68985.1 - 8.6e-06 25.3 0.3 1.1e-05 25.0 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX68985.1 - 2e-05 24.6 0.1 0.0051 16.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX68985.1 - 3.1e-05 24.0 0.0 5.6e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ORX68985.1 - 0.00078 19.3 0.1 0.0026 17.6 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 ORX68985.1 - 0.025 14.1 0.3 0.57 9.7 0.3 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B TetR_C_16 PF17920.1 ORX68985.1 - 0.026 14.7 0.2 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AAA_7 PF12775.7 ORX68985.1 - 0.034 13.6 0.1 0.059 12.9 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ORX68985.1 - 0.073 12.5 0.1 0.72 9.2 0.0 2.2 2 1 1 3 3 3 0 Bacterial TniB protein TIR_2 PF13676.6 ORX68985.1 - 0.11 13.2 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 TIR domain CHORD PF04968.12 ORX68986.1 - 3.6e-36 123.7 20.9 3e-21 75.9 6.1 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 ORX68986.1 - 3e-13 50.6 0.3 4.3e-13 50.1 0.3 1.2 1 0 0 1 1 1 1 CS domain BTK PF00779.19 ORX68986.1 - 0.04 13.8 10.6 0.36 10.7 0.8 3.5 3 0 0 3 3 3 0 BTK motif Trypan_PARP PF05887.11 ORX68986.1 - 0.14 12.2 9.3 0.23 11.4 9.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Sec5 PF15469.6 ORX68987.1 - 7.7e-44 149.8 0.0 1.4e-43 148.9 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec5 Cyclin_N PF00134.23 ORX68987.1 - 5.4e-18 65.0 0.3 9.7e-17 60.9 0.3 2.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain Vps51 PF08700.11 ORX68987.1 - 0.047 13.8 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Vps51/Vps67 DUF2072 PF09845.9 ORX68987.1 - 0.16 12.2 0.1 0.39 11.0 0.1 1.6 1 0 0 1 1 1 0 Zn-ribbon containing protein THDPS_M PF14789.6 ORX68987.1 - 0.19 11.9 0.0 0.53 10.4 0.0 1.8 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase middle Rep_fac_C PF08542.11 ORX68988.1 - 0.017 15.6 0.0 2.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Replication factor C C-terminal domain Transposase_1 PF01359.18 ORX68988.1 - 0.044 13.6 0.1 0.1 12.4 0.1 1.7 1 0 0 1 1 1 0 Transposase (partial DDE domain) GcrA PF07750.11 ORX68988.1 - 0.23 11.9 3.1 2 8.8 3.1 2.1 1 1 0 1 1 1 0 GcrA cell cycle regulator DUF4451 PF14616.6 ORX68989.1 - 0.039 14.2 0.6 0.071 13.3 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Zn_Tnp_IS1595 PF12760.7 ORX68989.1 - 0.32 11.0 4.6 2.5 8.1 0.1 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 ORX68989.1 - 0.32 11.1 1.6 2.2 8.5 0.4 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-RRN7 PF11781.8 ORX68989.1 - 0.47 10.2 2.7 12 5.6 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cytochrom_NNT PF03264.14 ORX68989.1 - 7.5 6.2 6.9 0.23 11.2 0.8 1.5 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Ribosomal_S26e PF01283.19 ORX68990.1 - 5e-29 100.9 0.7 5.9e-29 100.7 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Peptidase_U4 PF03419.13 ORX68991.1 - 0.082 12.2 1.6 0.11 11.8 1.6 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA bZIP_2 PF07716.15 ORX68992.1 - 1.3e-11 44.3 7.2 5.9e-11 42.3 7.2 2.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX68992.1 - 2.3e-08 34.0 12.2 7.3e-08 32.4 12.2 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX68992.1 - 0.0038 17.7 6.1 0.0038 17.7 6.1 2.1 2 0 0 2 2 2 1 bZIP Maf transcription factor Tnp_22_trimer PF17489.2 ORX68992.1 - 0.015 15.2 3.2 0.03 14.3 3.2 1.5 1 0 0 1 1 1 0 L1 transposable element trimerization domain Rho_Binding PF08912.11 ORX68992.1 - 0.036 14.9 5.0 0.12 13.2 5.0 2.0 1 0 0 1 1 1 0 Rho Binding SlyX PF04102.12 ORX68992.1 - 0.058 14.0 2.5 0.21 12.2 2.5 1.9 1 0 0 1 1 1 0 SlyX Shugoshin_N PF07558.11 ORX68992.1 - 0.064 13.1 1.4 0.2 11.6 1.4 1.9 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Spc24 PF08286.11 ORX68992.1 - 0.82 9.9 4.1 2.4 8.4 4.1 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DivIC PF04977.15 ORX68992.1 - 1.1 9.1 4.5 2.7 7.8 4.5 1.6 1 0 0 1 1 1 0 Septum formation initiator MPS2 PF17060.5 ORX68992.1 - 3.5 6.8 7.1 5.1 6.3 7.1 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Myb_DNA-binding PF00249.31 ORX68993.1 - 5.5e-06 26.5 0.1 1.3e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX68993.1 - 0.011 15.9 0.1 0.027 14.7 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain SLIDE PF09111.10 ORX68993.1 - 0.15 12.1 0.2 0.3 11.1 0.2 1.5 1 0 0 1 1 1 0 SLIDE SH3_1 PF00018.28 ORX68995.1 - 1.8e-20 72.2 0.0 6.2e-11 41.7 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ORX68995.1 - 1.7e-14 53.4 0.0 1.7e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ORX68995.1 - 1.8e-07 30.7 0.0 8.7e-06 25.3 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain PX PF00787.24 ORX68995.1 - 1.1e-05 25.4 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 PX domain Cpn60_TCP1 PF00118.24 ORX68997.1 - 3.9e-146 487.5 9.5 4.4e-146 487.3 9.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1064 PF06356.11 ORX68997.1 - 0.084 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1064) CRM1_repeat PF18777.1 ORX68997.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat Dak2 PF02734.17 ORX68997.1 - 0.12 12.2 3.6 0.23 11.4 0.4 2.7 2 1 1 3 3 3 0 DAK2 domain Maf PF02545.14 ORX68998.1 - 4e-39 134.1 0.0 4.8e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Arylesterase PF01731.20 ORX68999.1 - 4e-09 36.6 0.1 1.2e-08 35.0 0.1 1.9 1 1 0 1 1 1 1 Arylesterase TPR_12 PF13424.6 ORX69000.1 - 2.1e-07 31.2 8.1 0.0045 17.2 0.7 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69000.1 - 6.1e-07 29.1 7.7 0.024 14.7 0.2 4.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69000.1 - 1.7e-06 28.3 7.6 0.25 12.3 0.1 4.1 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX69000.1 - 1.3e-05 24.9 6.9 0.49 10.6 0.3 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69000.1 - 2.8e-05 23.7 2.3 0.063 13.1 0.9 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX69000.1 - 0.00013 22.3 8.9 0.43 11.3 1.3 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69000.1 - 0.00013 22.4 4.9 0.017 15.7 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69000.1 - 0.00041 20.3 4.5 0.71 10.2 0.4 4.4 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 ORX69000.1 - 0.0016 18.9 1.2 7.3 7.5 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69000.1 - 0.0024 18.5 5.2 6.2 7.5 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat Dak2 PF02734.17 ORX69000.1 - 0.052 13.4 0.1 8 6.3 0.0 2.3 2 0 0 2 2 2 0 DAK2 domain TPR_MalT PF17874.1 ORX69000.1 - 0.085 12.2 2.1 19 4.5 0.2 3.0 2 1 0 3 3 3 0 MalT-like TPR region TPR_10 PF13374.6 ORX69000.1 - 0.7 9.9 4.0 14 5.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69000.1 - 3.3 7.5 6.3 4.9 6.9 0.6 3.6 4 0 0 4 4 4 0 TPR repeat SAC3_GANP PF03399.16 ORX69001.1 - 2.7e-06 27.0 6.1 0.00072 19.0 6.1 3.2 1 1 0 1 1 1 1 SAC3/GANP family DUF4518 PF15008.6 ORX69001.1 - 5.9 6.0 8.4 15 4.6 8.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) Arylesterase PF01731.20 ORX69002.1 - 4.6e-08 33.2 0.0 1.5e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 ORX69002.1 - 4.2e-07 29.8 0.0 7.2e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Rod_C PF10493.9 ORX69003.1 - 1.4e-43 149.1 0.0 2.2e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Rough deal protein C-terminal region Alba PF01918.21 ORX69005.1 - 9.6e-09 34.9 0.1 1.3e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Alba Actin PF00022.19 ORX69006.1 - 3.6e-130 434.3 0.0 1.8e-129 431.9 0.0 1.8 1 1 0 1 1 1 1 Actin Rad21_Rec8 PF04824.16 ORX69006.1 - 0.15 11.3 0.0 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein MreB_Mbl PF06723.13 ORX69006.1 - 0.18 10.6 0.0 2.3 7.0 0.0 2.4 2 1 0 2 2 2 0 MreB/Mbl protein Syntaxin-6_N PF09177.11 ORX69007.1 - 2.1e-19 69.9 2.1 5.1e-19 68.7 0.3 2.0 1 1 1 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 ORX69007.1 - 1.6e-06 28.0 2.0 3.6e-06 26.9 2.0 1.6 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.9 ORX69007.1 - 0.00051 19.8 1.8 0.0006 19.6 1.8 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Prominin PF05478.11 ORX69007.1 - 0.0069 14.4 3.0 0.018 13.1 1.9 1.7 1 1 1 2 2 2 1 Prominin DUF5089 PF17002.5 ORX69007.1 - 0.02 14.8 4.5 0.05 13.5 4.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) DUF1804 PF08822.11 ORX69007.1 - 0.02 14.9 0.2 0.032 14.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1804) DUF2207 PF09972.9 ORX69007.1 - 0.13 11.0 0.2 0.22 10.2 0.1 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1664 PF07889.12 ORX69007.1 - 0.16 12.0 5.1 1.9 8.5 2.5 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 ORX69007.1 - 0.21 11.3 0.9 0.33 10.7 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) TssO PF17561.2 ORX69007.1 - 1.3 9.1 0.0 1.3 9.1 0.0 3.5 2 1 2 4 4 4 0 Type VI secretion system, TssO DUF16 PF01519.16 ORX69007.1 - 4.7 7.8 7.9 15 6.1 4.0 2.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 DSPc PF00782.20 ORX69008.1 - 3.8e-24 85.0 0.0 1.6e-22 79.7 0.0 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX69008.1 - 0.02 14.5 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Zn_Tnp_IS1595 PF12760.7 ORX69008.1 - 0.026 14.5 5.0 1.1 9.3 0.1 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Opacity PF02462.15 ORX69009.1 - 0.1 12.7 0.9 0.4 10.8 0.0 2.3 3 0 0 3 3 3 0 Opacity family porin protein Herpes_LMP2 PF07415.11 ORX69009.1 - 0.57 8.9 2.0 0.9 8.2 2.0 1.4 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein HMG_box PF00505.19 ORX69012.1 - 2.6e-14 53.4 0.1 7.1e-14 52.0 0.0 1.7 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX69012.1 - 4.9e-07 30.3 0.0 8.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain SMC_N PF02463.19 ORX69013.1 - 2.1e-16 60.0 20.1 1.4e-15 57.3 20.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX69013.1 - 1.5e-15 58.2 0.0 1.5e-15 58.2 0.0 5.0 2 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 ORX69013.1 - 2.3e-11 44.1 0.0 2.2e-09 37.5 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ORX69013.1 - 1.8e-06 28.0 0.2 0.0077 16.1 0.6 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX69013.1 - 1.3e-05 24.9 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 ORX69013.1 - 0.016 15.4 0.2 0.061 13.6 0.0 2.2 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Laminin_II PF06009.12 ORX69013.1 - 2.1 8.4 55.9 0.062 13.3 4.2 6.5 3 2 2 6 6 6 0 Laminin Domain II Mit_ribos_Mrp51 PF11709.8 ORX69014.1 - 4.8e-18 65.9 3.9 1.1e-15 58.1 1.4 2.3 1 1 1 2 2 2 2 Mitochondrial ribosomal protein subunit DUF5427 PF10310.9 ORX69016.1 - 3.4e-12 46.1 10.6 1.2e-09 37.7 10.9 2.6 2 1 0 2 2 2 2 Family of unknown function (DUF5427) MOR2-PAG1_mid PF14228.6 ORX69016.1 - 0.051 11.2 0.4 0.077 10.6 0.4 1.2 1 0 0 1 1 1 0 Cell morphogenesis central region Cupin_3 PF05899.12 ORX69016.1 - 0.053 13.2 0.1 0.21 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF861) RNA_pol_Rpc4 PF05132.14 ORX69016.1 - 0.76 10.2 3.3 44 4.5 3.7 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 E1-E2_ATPase PF00122.20 ORX69017.1 - 7.2e-46 156.0 0.8 7.2e-46 156.0 0.8 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX69017.1 - 3e-35 121.6 1.0 3e-35 121.6 1.0 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX69017.1 - 1.7e-21 77.5 1.6 7e-21 75.5 1.6 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX69017.1 - 2.5e-17 62.7 0.0 4.7e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX69017.1 - 1e-14 54.0 0.0 2e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX69017.1 - 0.00011 22.0 4.5 0.02 14.6 2.4 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF1622 PF07784.11 ORX69017.1 - 0.07 13.0 1.1 0.19 11.6 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1622) Forkhead PF00250.18 ORX69018.1 - 4.4e-38 129.4 0.4 4.9e-38 129.3 0.4 1.0 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 ORX69018.1 - 0.011 16.0 0.2 0.018 15.4 0.2 1.4 1 1 0 1 1 1 0 linker histone H1 and H5 family zf-LYAR PF08790.11 ORX69022.1 - 2e-15 56.3 2.6 2e-15 56.3 2.6 2.4 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger Cript PF10235.9 ORX69022.1 - 0.0045 17.5 2.8 0.0045 17.5 2.8 2.2 2 1 0 2 2 2 1 Microtubule-associated protein CRIPT zf-HYPF PF07503.12 ORX69022.1 - 0.026 14.3 4.3 0.061 13.1 4.3 1.6 1 1 0 1 1 1 0 HypF finger DM PF00751.18 ORX69022.1 - 0.055 13.4 5.5 0.1 12.5 5.5 1.5 1 0 0 1 1 1 0 DM DNA binding domain zf_UBZ PF18439.1 ORX69022.1 - 0.058 13.0 1.0 0.28 10.8 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger LIM PF00412.22 ORX69022.1 - 0.089 13.0 4.8 0.25 11.6 4.8 1.8 1 1 0 1 1 1 0 LIM domain zf_C2H2_ZHX PF18387.1 ORX69022.1 - 0.19 11.4 9.4 0.33 10.6 1.1 3.3 2 2 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Cytomega_UL84 PF06284.11 ORX69022.1 - 0.26 9.7 2.9 0.24 9.8 2.9 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PA26 PF04636.13 ORX69022.1 - 0.39 9.6 4.1 0.46 9.3 4.1 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.22 ORX69022.1 - 2.3 7.4 6.3 2.2 7.4 6.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter UPF0242 PF06785.11 ORX69022.1 - 3.4 7.7 8.9 4.3 7.4 8.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Rho_GDI PF02115.17 ORX69023.1 - 6.9e-64 215.2 0.1 8.2e-64 215.0 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Cgr1 PF03879.14 ORX69024.1 - 1.4e-18 67.2 30.7 1.8e-18 66.9 30.7 1.0 1 0 0 1 1 1 1 Cgr1 family AAA_11 PF13086.6 ORX69024.1 - 6.8 6.4 13.7 6.6 6.4 13.7 1.0 1 0 0 1 1 1 0 AAA domain cNMP_binding PF00027.29 ORX69025.1 - 1.1e-43 147.3 0.1 1.4e-22 79.6 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ORX69025.1 - 2.8e-09 36.5 0.3 2.8e-09 36.5 0.3 1.7 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit LIM PF00412.22 ORX69026.1 - 3.2e-08 33.7 1.1 3.2e-08 33.7 1.1 1.9 2 0 0 2 2 2 1 LIM domain Methyltransf_13 PF08421.11 ORX69026.1 - 0.017 15.4 1.1 0.043 14.1 1.1 1.7 1 0 0 1 1 1 0 Putative zinc binding domain PPP4R2 PF09184.11 ORX69026.1 - 1.6 8.2 8.6 0.42 10.2 5.2 1.7 2 0 0 2 2 2 0 PPP4R2 CDC45 PF02724.14 ORX69026.1 - 8.3 4.6 6.7 12 4.0 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein FAD_binding_8 PF08022.12 ORX69027.1 - 6.1e-17 61.7 0.0 1.7e-16 60.3 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ORX69027.1 - 5.6e-11 42.8 0.1 0.00045 20.4 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ORX69027.1 - 3e-07 30.6 6.1 8e-06 26.0 6.1 2.4 1 1 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX69027.1 - 0.0043 17.7 0.1 0.016 15.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 ORX69028.1 - 2.1e-14 53.5 0.0 7.4e-14 51.8 0.0 1.9 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ORX69028.1 - 6.5e-11 42.6 0.0 1.9e-10 41.1 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ORX69028.1 - 0.012 15.7 3.9 0.013 15.6 1.5 2.2 1 1 2 3 3 3 0 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX69028.1 - 0.13 12.9 0.0 0.21 12.2 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Peptidase_M36 PF02128.15 ORX69029.1 - 2.4e-117 392.3 7.3 1.3e-98 330.6 0.1 2.4 2 1 0 2 2 2 2 Fungalysin metallopeptidase (M36) Peptidase_M4_C PF02868.15 ORX69029.1 - 0.00059 19.7 0.0 0.0017 18.3 0.0 1.8 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain FTP PF07504.13 ORX69029.1 - 0.17 11.8 4.4 0.093 12.6 1.5 2.2 2 1 0 2 2 2 0 Fungalysin/Thermolysin Propeptide Motif Peptidase_M36 PF02128.15 ORX69030.1 - 1.1e-125 419.7 16.7 9e-107 357.4 11.5 2.2 2 0 0 2 2 2 2 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX69030.1 - 3e-12 46.2 1.8 3e-12 46.2 1.8 2.6 3 0 0 3 3 3 1 Fungalysin/Thermolysin Propeptide Motif KilA-N PF04383.13 ORX69033.1 - 1.5e-08 34.4 0.1 3.1e-07 30.2 0.1 2.6 2 1 0 2 2 2 1 KilA-N domain SPRY PF00622.28 ORX69034.1 - 1.2e-08 35.1 0.1 0.0056 16.8 0.0 3.2 3 0 0 3 3 3 2 SPRY domain PHD PF00628.29 ORX69034.1 - 0.022 14.6 14.3 0.039 13.8 14.3 1.4 1 0 0 1 1 1 0 PHD-finger Spt20 PF12090.8 ORX69034.1 - 0.57 9.8 9.8 0.89 9.1 9.8 1.2 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 ORX69034.1 - 3.4 7.8 11.5 10 6.3 11.5 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 G-patch PF01585.23 ORX69035.1 - 1.3e-09 37.8 0.4 3.3e-09 36.5 0.4 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX69035.1 - 0.013 15.6 0.1 0.013 15.6 0.1 1.9 2 0 0 2 2 2 0 G-patch domain Glyco_hydro_101 PF12905.7 ORX69035.1 - 0.035 13.5 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase Ras PF00071.22 ORX69036.1 - 1.5e-56 190.5 0.0 1.8e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX69036.1 - 2.2e-36 124.7 0.0 3.9e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX69036.1 - 1.4e-15 57.2 0.0 4.5e-15 55.5 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX69036.1 - 1.1e-06 28.7 0.0 7.4e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX69036.1 - 1.8e-06 27.5 0.0 2.2e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX69036.1 - 0.0015 18.1 0.0 0.0036 16.9 0.0 1.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX69036.1 - 0.0064 16.9 0.9 0.016 15.6 0.5 1.8 1 1 1 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX69036.1 - 0.11 12.4 0.0 1.6 8.6 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase Peptidase_M41 PF01434.18 ORX69037.1 - 4e-68 229.0 0.1 6.1e-68 228.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX69037.1 - 9.8e-44 149.0 0.0 2e-43 147.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX69037.1 - 5.7e-12 45.2 0.1 1.3e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 ORX69037.1 - 4.9e-07 30.1 0.0 1.1e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_16 PF13191.6 ORX69037.1 - 0.0008 19.8 0.7 0.075 13.4 0.1 3.1 3 1 0 4 4 4 1 AAA ATPase domain TIP49 PF06068.13 ORX69037.1 - 0.0018 17.5 0.1 0.004 16.4 0.1 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 ORX69037.1 - 0.0022 18.2 0.0 0.54 10.5 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX69037.1 - 0.0038 17.2 0.4 0.025 14.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX69037.1 - 0.0048 16.6 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX69037.1 - 0.0051 16.9 0.1 0.028 14.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 ORX69037.1 - 0.0052 17.2 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX69037.1 - 0.027 14.2 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 ORX69037.1 - 0.099 12.8 0.0 0.33 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ORX69037.1 - 0.15 11.4 0.2 0.38 10.1 0.2 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cyclin_N PF00134.23 ORX69038.1 - 0.016 15.0 0.0 0.22 11.2 0.0 2.2 1 1 0 1 1 1 0 Cyclin, N-terminal domain tRNA-synt_1b PF00579.25 ORX69039.1 - 2.3e-65 220.8 0.3 2.5e-64 217.4 0.3 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) NCD1 PF04904.13 ORX69039.1 - 0.081 12.9 0.0 0.29 11.2 0.0 1.9 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) DUF2161 PF09929.9 ORX69039.1 - 0.16 12.1 0.4 0.39 10.8 0.4 1.6 1 0 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) ELFV_dehydrog_N PF02812.18 ORX69040.1 - 8.7e-56 187.4 0.0 1.4e-55 186.7 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ORX69040.1 - 5.5e-49 167.1 0.0 3e-47 161.4 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ceramidase PF05875.12 ORX69041.1 - 9.3e-79 264.6 18.1 1e-78 264.4 18.1 1.0 1 0 0 1 1 1 1 Ceramidase EamA PF00892.20 ORX69041.1 - 0.46 10.6 5.4 5.7 7.1 0.4 2.3 2 0 0 2 2 2 0 EamA-like transporter family Peptidase_U4 PF03419.13 ORX69041.1 - 7.7 5.7 12.3 0.33 10.2 1.9 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA Ceramidase PF05875.12 ORX69042.1 - 4.9e-77 258.9 14.3 5.5e-77 258.7 14.3 1.0 1 0 0 1 1 1 1 Ceramidase Ion_trans_2 PF07885.16 ORX69042.1 - 0.0033 17.4 5.7 0.3 11.1 0.3 2.6 2 0 0 2 2 2 2 Ion channel MBOAT_2 PF13813.6 ORX69042.1 - 0.012 15.8 0.8 0.012 15.8 0.8 2.7 3 0 0 3 3 3 0 Membrane bound O-acyl transferase family MerC PF03203.14 ORX69042.1 - 0.029 14.8 14.4 0.069 13.6 6.2 2.8 1 1 1 2 2 2 0 MerC mercury resistance protein LD_cluster2 PF18163.1 ORX69042.1 - 0.24 10.9 0.1 0.35 10.4 0.1 1.1 1 0 0 1 1 1 0 SLOG cluster2 NAD_kinase PF01513.21 ORX69043.1 - 3.6e-43 147.8 0.7 2e-24 86.3 0.2 2.0 1 1 1 2 2 2 2 ATP-NAD kinase DAGK_cat PF00781.24 ORX69043.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Herpes_UL25 PF01499.16 ORX69044.1 - 0.0087 14.6 0.0 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus UL25 family DUF2516 PF10724.9 ORX69044.1 - 7.1 7.0 7.0 8.8 6.7 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2516) zf-Nse PF11789.8 ORX69045.1 - 5.2e-19 67.8 0.1 8.5e-19 67.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ORX69045.1 - 4.9e-06 26.5 0.6 2.6e-05 24.2 0.1 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX69045.1 - 5.7e-06 26.1 1.3 5.7e-06 26.1 1.3 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX69045.1 - 0.004 17.3 0.4 0.0078 16.3 0.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ORX69045.1 - 0.013 15.4 0.7 0.027 14.4 0.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 ORX69045.1 - 0.015 14.7 0.6 0.035 13.5 0.0 1.7 1 1 1 2 2 2 0 Rtf2 RING-finger zf-MIZ PF02891.20 ORX69045.1 - 0.018 14.8 3.6 0.047 13.5 3.6 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger U-box PF04564.15 ORX69045.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 U-box domain AMMECR1 PF01871.17 ORX69046.1 - 9.2e-49 165.2 0.0 1e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 NRDE-2 PF08424.10 ORX69048.1 - 6.7e-57 193.0 0.0 1e-56 192.5 0.0 1.2 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference TPR_12 PF13424.6 ORX69048.1 - 0.057 13.7 0.1 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Phage_P2_GpU PF06995.11 ORX69048.1 - 0.15 11.7 0.1 0.39 10.3 0.1 1.7 1 0 0 1 1 1 0 Phage P2 GpU Pkinase PF00069.25 ORX69052.1 - 4.9e-28 98.2 0.0 3.3e-26 92.2 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69052.1 - 4.4e-17 62.2 0.0 5.9e-13 48.7 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase NAD_binding_1 PF00175.21 ORX69056.1 - 5.1e-24 85.0 0.0 1.8e-23 83.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX69056.1 - 2e-06 28.1 0.3 3.3e-05 24.1 0.2 2.6 1 1 1 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ORX69056.1 - 0.00054 20.1 0.0 0.00084 19.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Dynamitin PF04912.14 ORX69057.1 - 1.2e-32 113.8 24.2 1.2e-23 84.2 5.8 3.5 1 1 1 2 2 2 2 Dynamitin FlaC_arch PF05377.11 ORX69057.1 - 0.0014 18.9 6.8 0.94 9.9 2.9 4.6 3 1 1 4 4 4 2 Flagella accessory protein C (FlaC) TTKRSYEDQ PF10212.9 ORX69057.1 - 0.0015 17.6 2.4 0.0015 17.6 2.4 1.4 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein TPR_MLP1_2 PF07926.12 ORX69057.1 - 0.0052 16.8 1.6 0.0052 16.8 1.6 3.1 2 2 1 3 3 3 1 TPR/MLP1/MLP2-like protein PG_binding_1 PF01471.18 ORX69057.1 - 0.0079 16.4 1.0 4.1 7.7 0.0 3.0 3 0 0 3 3 3 1 Putative peptidoglycan binding domain BLOC1_2 PF10046.9 ORX69057.1 - 0.019 15.3 5.4 0.68 10.3 2.0 3.5 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF745 PF05335.13 ORX69057.1 - 0.022 14.5 0.7 0.022 14.5 0.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF745) AlkA_N PF06029.11 ORX69057.1 - 0.049 13.9 0.3 0.63 10.3 0.1 2.4 2 0 0 2 2 2 0 AlkA N-terminal domain DUF1664 PF07889.12 ORX69057.1 - 0.13 12.3 3.6 1 9.4 1.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Tnp_22_trimer PF17489.2 ORX69057.1 - 0.31 11.0 1.6 47 4.0 0.0 4.3 5 0 0 5 5 5 0 L1 transposable element trimerization domain Prominin PF05478.11 ORX69057.1 - 0.32 8.9 4.9 0.17 9.8 1.1 1.9 2 0 0 2 2 2 0 Prominin Baculo_PEP_C PF04513.12 ORX69057.1 - 0.71 9.9 8.2 0.2 11.7 0.4 3.0 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 ORX69057.1 - 0.72 8.7 12.0 0.055 12.3 3.7 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1515 PF07439.11 ORX69057.1 - 0.8 9.8 6.4 11 6.1 0.2 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1515) ABC_tran_CTD PF16326.5 ORX69057.1 - 0.89 9.8 14.9 17 5.7 0.0 5.0 2 1 1 4 4 4 0 ABC transporter C-terminal domain PspB PF06667.12 ORX69057.1 - 0.92 9.6 9.7 19 5.4 0.0 4.9 5 1 0 5 5 4 0 Phage shock protein B JIP_LZII PF16471.5 ORX69057.1 - 1.1 9.5 5.6 0.96 9.7 0.5 3.2 3 1 1 4 4 3 0 JNK-interacting protein leucine zipper II ApoLp-III PF07464.11 ORX69057.1 - 1.7 8.7 9.7 2.9 8.0 0.6 2.9 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) YabA PF06156.13 ORX69057.1 - 2.3 8.9 6.9 10 6.9 0.6 3.3 2 1 1 3 3 3 0 Initiation control protein YabA XhlA PF10779.9 ORX69057.1 - 4.1 7.7 5.7 14 6.0 1.7 3.6 3 1 0 3 3 3 0 Haemolysin XhlA ECH_2 PF16113.5 ORX69058.1 - 0.0071 15.9 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Toxin_23 PF08093.11 ORX69062.1 - 0.24 11.6 6.8 0.36 11.0 6.8 1.3 1 0 0 1 1 1 0 Magi 5 toxic peptide family RibD_C PF01872.17 ORX69063.1 - 3.3e-33 115.2 0.0 4.6e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 RibD C-terminal domain DUF3652 PF12372.8 ORX69063.1 - 0.1 12.5 0.2 0.24 11.4 0.2 1.6 1 0 0 1 1 1 0 Huntingtin protein region SHMT PF00464.19 ORX69064.1 - 4.2e-202 671.0 0.0 4.9e-202 670.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase MIR PF02815.19 ORX69065.1 - 4.1e-15 56.1 5.3 2.7e-08 33.9 2.3 2.9 1 1 2 3 3 3 3 MIR domain Ins145_P3_rec PF08709.11 ORX69065.1 - 7.4e-06 25.3 0.3 4.2e-05 22.8 0.0 1.9 1 1 1 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 ORX69066.1 - 8.6e-13 48.5 9.1 1.8e-11 44.3 4.4 3.4 2 1 2 4 4 4 3 MIR domain DUF3824 PF12868.7 ORX69066.1 - 0.00091 19.9 24.5 0.00091 19.9 24.5 2.7 1 1 1 2 2 2 1 Domain of unknwon function (DUF3824) Ins145_P3_rec PF08709.11 ORX69066.1 - 0.012 14.8 0.4 0.012 14.8 0.4 2.4 2 1 1 3 3 3 0 Inositol 1,4,5-trisphosphate/ryanodine receptor MAP7 PF05672.11 ORX69066.1 - 0.013 15.2 3.8 0.013 15.2 3.8 2.2 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Ribosomal_60s PF00428.19 ORX69066.1 - 0.47 11.1 2.7 0.86 10.2 2.7 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pre-SET PF05033.16 ORX69067.1 - 0.041 14.5 0.7 0.09 13.4 0.7 1.6 1 0 0 1 1 1 0 Pre-SET motif Glyco_hydro_38N PF01074.22 ORX69069.1 - 1.2e-64 218.4 2.0 7.5e-54 183.0 2.1 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ORX69069.1 - 1.3e-56 192.0 0.0 2.3e-56 191.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ORX69069.1 - 5.8e-25 87.3 0.0 1.3e-24 86.1 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ORX69069.1 - 5.3e-12 45.7 0.0 1.1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain TMEM135_C_rich PF15982.5 ORX69069.1 - 0.15 12.6 0.0 0.3 11.7 0.0 1.4 1 0 0 1 1 1 0 N-terminal cysteine-rich region of Transmembrane protein 135 OPT PF03169.15 ORX69070.1 - 5.2e-147 491.1 50.3 2.7e-145 485.4 50.3 2.0 1 1 0 1 1 1 1 OPT oligopeptide transporter protein Na_Pi_cotrans PF02690.15 ORX69070.1 - 0.4 10.8 0.1 0.4 10.8 0.1 4.4 5 0 0 5 5 5 0 Na+/Pi-cotransporter Sugar_tr PF00083.24 ORX69071.1 - 5.1e-27 94.8 1.1 3.6e-26 92.1 1.1 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter Haem_oxygenas_2 PF14518.6 ORX69071.1 - 0.082 12.7 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 Iron-containing redox enzyme Cytochrom_B561 PF03188.16 ORX69071.1 - 0.84 9.8 6.3 0.077 13.1 1.8 1.6 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 Kinesin PF00225.23 ORX69072.1 - 1.4e-11 43.9 0.0 2.7e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain TMCO5 PF14992.6 ORX69072.1 - 0.22 11.1 0.9 0.48 9.9 0.2 1.8 1 1 1 2 2 2 0 TMCO5 family HALZ PF02183.18 ORX69072.1 - 2 8.7 4.0 8.7 6.7 0.1 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper ADIP PF11559.8 ORX69072.1 - 2 8.5 10.8 5.8 7.0 6.2 2.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 ORX69072.1 - 2.3 8.7 18.8 0.86 10.1 0.2 4.3 4 0 0 4 4 4 0 Cell division protein ZapB UPAR_LY6_2 PF16975.5 ORX69073.1 - 0.067 13.4 1.0 6.3 7.0 0.0 2.2 1 1 1 2 2 2 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Aldo_ket_red PF00248.21 ORX69074.1 - 9.8e-46 156.3 0.0 3.4e-44 151.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family SO_alpha_A3 PF17806.1 ORX69074.1 - 0.075 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Sarcosine oxidase A3 domain adh_short PF00106.25 ORX69076.1 - 1.8e-42 145.0 0.5 2e-42 144.9 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX69076.1 - 4.3e-36 124.6 0.5 5e-36 124.4 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX69076.1 - 3e-08 33.8 0.2 4e-08 33.4 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX69076.1 - 0.0012 18.3 0.1 0.0023 17.4 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Asparaginase_2 PF01112.18 ORX69077.1 - 1.2e-54 185.4 11.4 1.4e-54 185.2 11.4 1.0 1 0 0 1 1 1 1 Asparaginase DPBB_1 PF03330.18 ORX69079.1 - 3.2e-10 40.2 0.0 4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX69079.1 - 2.1e-05 24.4 0.2 2.5e-05 24.1 0.2 1.2 1 0 0 1 1 1 1 Barwin family zinc_ribbon_10 PF10058.9 ORX69079.1 - 0.0062 16.2 0.2 0.0092 15.7 0.2 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein F-box-like PF12937.7 ORX69080.1 - 0.00033 20.5 1.7 0.0011 18.8 0.3 2.5 2 0 0 2 2 2 1 F-box-like Resistin PF06954.11 ORX69080.1 - 0.013 16.0 0.5 0.031 14.8 0.5 1.6 1 0 0 1 1 1 0 Resistin R3H-assoc PF13902.6 ORX69080.1 - 0.013 15.8 0.9 0.03 14.7 0.9 1.6 1 0 0 1 1 1 0 R3H-associated N-terminal domain Lactamase_B_2 PF12706.7 ORX69081.1 - 1.2e-30 106.5 0.0 2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX69081.1 - 2.9e-11 43.5 0.0 4.1e-11 43.0 0.0 1.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX69081.1 - 1.3e-05 25.3 0.9 0.00052 20.1 0.2 2.8 2 2 0 3 3 3 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX69082.1 - 6.6e-34 117.2 0.0 8.8e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX69082.1 - 4.2e-13 49.5 0.1 6e-13 49.0 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX69082.1 - 8.8e-07 29.1 0.4 0.00022 21.3 0.2 2.6 2 1 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ORX69082.1 - 0.19 11.1 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Chitin_synth_2 PF03142.15 ORX69083.1 - 2.5e-257 854.7 0.0 3.5e-257 854.2 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX69083.1 - 5.4e-06 26.5 3.7 5.4e-06 26.5 3.7 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX69083.1 - 7.4e-05 22.8 0.0 0.00025 21.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ORX69083.1 - 0.041 13.4 0.1 0.86 9.1 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 21 Cyt-b5 PF00173.28 ORX69083.1 - 0.077 13.2 0.0 0.56 10.4 0.0 2.3 2 0 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 ORX69083.1 - 0.18 11.6 0.0 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 2 UBX PF00789.20 ORX69084.1 - 1.6e-05 25.0 0.0 8e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 UBX domain UBA PF00627.31 ORX69084.1 - 0.0013 18.6 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain zf_UBZ PF18439.1 ORX69084.1 - 0.038 13.6 0.2 0.072 12.7 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger RPT PF13446.6 ORX69084.1 - 0.22 11.5 2.0 0.4 10.6 0.3 2.2 2 0 0 2 2 2 0 A repeated domain in UCH-protein Atg14 PF10186.9 ORX69084.1 - 0.29 10.2 16.4 0.41 9.7 16.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Borrelia_P83 PF05262.11 ORX69084.1 - 0.61 8.5 22.4 0.68 8.4 22.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein V_ATPase_I PF01496.19 ORX69084.1 - 3.9 5.3 10.5 4.4 5.1 10.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 ORX69084.1 - 4.8 6.9 25.7 0.24 11.2 1.2 2.1 1 1 1 2 2 2 0 Ryanodine Receptor TM 4-6 CpXC PF14353.6 ORX69084.1 - 5.9 7.0 9.9 16 5.6 10.0 1.8 1 1 0 1 1 1 0 CpXC protein RNF220 PF15926.5 ORX69086.1 - 0.034 13.8 0.1 0.042 13.5 0.1 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Actin_micro PF17003.5 ORX69086.1 - 0.042 13.0 0.1 0.042 13.0 0.1 1.0 1 0 0 1 1 1 0 Putative actin-like family Complex1_49kDa PF00346.19 ORX69087.1 - 3.8e-121 403.3 0.1 4.7e-121 403.0 0.1 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 ORX69087.1 - 0.14 11.1 0.0 0.39 9.6 0.0 1.8 2 0 0 2 2 2 0 Nickel-dependent hydrogenase GST_N_4 PF17172.4 ORX69088.1 - 1.1e-15 58.2 0.0 1.3e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 ORX69088.1 - 1.5e-13 51.1 0.0 1.9e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_3 PF13417.6 ORX69088.1 - 0.0058 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain TANGO2 PF05742.12 ORX69089.1 - 1.8e-44 152.7 0.0 1.2e-41 143.4 0.0 2.0 1 1 1 2 2 2 2 Transport and Golgi organisation 2 CPSase_L_D2 PF02786.17 ORX69090.1 - 1.6e-73 246.7 0.5 3.3e-73 245.7 0.1 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 ORX69090.1 - 4.2e-28 97.6 0.0 1.3e-27 96.0 0.0 1.9 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 ORX69090.1 - 7e-24 84.5 0.9 8.2e-22 77.8 0.0 3.5 3 0 0 3 3 3 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 ORX69090.1 - 2.4e-16 59.3 2.1 5.6e-16 58.1 2.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX69090.1 - 1.2e-09 38.0 0.0 3.1e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX69090.1 - 4.6e-09 36.1 0.1 1.3e-08 34.6 0.1 1.7 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ORX69090.1 - 6.4e-05 22.7 0.4 0.5 10.2 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 ORX69090.1 - 0.00059 19.9 0.1 0.0015 18.6 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 ORX69090.1 - 0.0019 17.9 0.0 0.007 16.0 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_3 PF13437.6 ORX69090.1 - 0.0026 18.4 1.7 1 10.1 0.0 3.4 4 0 0 4 4 3 1 HlyD family secretion protein GARS_A PF01071.19 ORX69090.1 - 0.0032 17.3 0.1 0.0061 16.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 ORX69090.1 - 0.012 14.8 0.0 0.032 13.5 0.0 1.6 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 ORX69090.1 - 0.041 13.8 0.3 0.11 12.5 0.3 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein ATP-grasp_4 PF13535.6 ORX69090.1 - 0.12 12.0 0.1 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain Amidohydro_2 PF04909.14 ORX69091.1 - 2.4e-05 24.3 0.0 6.5e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 ORX69091.1 - 6.5e-05 22.4 0.0 0.0014 18.1 0.0 2.0 1 1 0 2 2 2 1 Amidohydrolase family zf-Dof PF02701.15 ORX69091.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Dof domain, zinc finger Peptidase_M36 PF02128.15 ORX69092.1 - 4.6e-127 424.2 8.3 5.1e-126 420.8 8.3 2.0 1 1 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX69092.1 - 6.4e-13 48.3 1.7 6.4e-13 48.3 1.7 2.2 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4 PF01447.18 ORX69092.1 - 0.65 10.5 0.0 0.65 10.5 0.0 3.1 3 1 0 3 3 3 0 Thermolysin metallopeptidase, catalytic domain Peptidase_M36 PF02128.15 ORX69094.1 - 2e-126 422.1 6.0 2.6e-126 421.7 6.0 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX69094.1 - 1.4e-09 37.6 0.7 1.4e-09 37.6 0.7 2.3 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif P21-Arc PF04062.14 ORX69095.1 - 1.2e-67 227.3 0.0 1.4e-67 227.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Cas1_AcylT PF07779.12 ORX69097.1 - 3.5e-117 392.2 23.5 6e-117 391.5 23.5 1.3 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p UNC45-central PF11701.8 ORX69098.1 - 0.00013 22.0 1.3 0.17 11.9 0.1 2.6 2 0 0 2 2 2 2 Myosin-binding striated muscle assembly central AAA_7 PF12775.7 ORX69098.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HEAT PF02985.22 ORX69098.1 - 1 9.8 0.0 1 9.8 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat AWS PF17907.1 ORX69099.1 - 0.19 11.8 2.7 0.32 11.1 2.7 1.4 1 0 0 1 1 1 0 AWS domain Rep_fac-A_C PF08646.10 ORX69100.1 - 7.5e-53 178.2 2.0 9.9e-52 174.6 0.9 2.3 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ORX69100.1 - 1.4e-18 66.6 0.0 1.3e-17 63.5 0.0 2.2 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ORX69100.1 - 1.2e-09 38.0 1.1 9.6e-09 35.1 0.2 2.7 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 ORX69100.1 - 9.9e-06 25.4 0.1 0.0052 16.5 0.0 2.5 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 Rep-A_N PF04057.12 ORX69100.1 - 3.2e-05 23.9 0.0 9.6e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF4539 PF15072.6 ORX69100.1 - 0.0021 18.1 0.0 0.03 14.4 0.0 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF4539) DUF4503 PF14951.6 ORX69100.1 - 0.0043 15.6 0.2 0.0066 15.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) IBR PF01485.21 ORX69100.1 - 0.045 14.0 1.1 0.12 12.7 1.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF223 PF02721.14 ORX69100.1 - 0.094 13.0 0.4 0.24 11.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF223 DUF658 PF04936.12 ORX69100.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF658) POT1 PF02765.17 ORX69100.1 - 0.12 12.2 0.1 0.54 10.1 0.1 2.1 2 0 0 2 2 2 0 Telomeric single stranded DNA binding POT1/CDC13 zf-AN1 PF01428.16 ORX69100.1 - 0.21 11.8 1.2 0.41 10.9 1.2 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger zf-C2H2_4 PF13894.6 ORX69104.1 - 0.038 14.8 0.3 0.038 14.8 0.3 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 ORX69104.1 - 0.13 12.4 0.3 0.13 12.4 0.3 1.9 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.26 ORX69104.1 - 0.61 10.7 0.3 0.61 10.7 0.3 3.2 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ORX69104.1 - 1 9.7 6.1 1 9.7 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RNase_T PF00929.24 ORX69105.1 - 1.2e-13 51.9 0.0 2.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Exonuclease ERCC4 PF02732.15 ORX69106.1 - 0.05 13.8 0.1 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 ERCC4 domain CSRNP_N PF16019.5 ORX69106.1 - 0.14 12.1 4.8 0.039 13.9 1.4 1.8 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus SRP-alpha_N PF04086.13 ORX69106.1 - 0.5 10.2 6.3 0.86 9.5 6.3 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ribosomal_60s PF00428.19 ORX69106.1 - 0.58 10.8 7.8 0.33 11.5 1.3 2.9 2 1 1 3 3 3 0 60s Acidic ribosomal protein Radial_spoke_3 PF06098.11 ORX69106.1 - 1.3 8.2 10.3 3 7.1 10.3 1.5 1 0 0 1 1 1 0 Radial spoke protein 3 Ribosomal_L31 PF01197.18 ORX69107.1 - 4e-08 33.4 0.0 7.1e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 DUF1746 PF08508.10 ORX69108.1 - 0.0038 17.5 3.6 0.006 16.9 3.6 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Fcf1 PF04900.12 ORX69110.1 - 4.3e-39 132.9 2.2 4.3e-39 132.9 2.2 1.5 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 ORX69110.1 - 2.5e-11 43.9 0.2 6.1e-11 42.6 0.0 1.6 2 0 0 2 2 2 1 PIN like domain GCV_T PF01571.21 ORX69110.1 - 0.21 10.9 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain EMC3_TMCO1 PF01956.16 ORX69110.1 - 1.1 8.9 5.8 0.91 9.2 3.7 1.7 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like zf-C2H2 PF00096.26 ORX69111.1 - 4.1e-08 33.2 11.9 0.00034 20.9 1.3 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX69111.1 - 1.1e-06 28.7 17.7 0.0041 17.5 4.6 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX69111.1 - 4.5e-06 27.1 10.7 0.0073 17.1 3.0 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX69111.1 - 1.2e-05 25.5 3.1 0.00046 20.5 1.2 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 ORX69111.1 - 0.00078 19.7 3.4 0.0011 19.2 3.4 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 ORX69111.1 - 0.0015 18.7 1.9 0.16 12.3 1.0 2.7 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 ORX69111.1 - 0.0033 17.4 1.9 1.7 8.7 0.1 2.3 2 1 0 2 2 2 2 BED zinc finger Rad50_zn_hook PF04423.14 ORX69111.1 - 0.012 15.4 0.4 0.027 14.3 0.1 1.7 2 0 0 2 2 2 0 Rad50 zinc hook motif Zn_ribbon_SprT PF17283.2 ORX69111.1 - 0.019 14.9 3.4 0.39 10.7 0.7 2.3 2 1 0 2 2 2 0 SprT-like zinc ribbon domain Zn-C2H2_12 PF18112.1 ORX69111.1 - 0.021 15.3 2.4 0.24 11.9 0.3 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_11 PF16622.5 ORX69111.1 - 0.058 13.2 7.0 0.29 10.9 0.7 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 ORX69111.1 - 0.058 13.3 1.4 0.3 11.0 1.0 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) FOXP-CC PF16159.5 ORX69111.1 - 0.082 13.5 1.6 0.37 11.4 0.0 2.0 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX69111.1 - 0.55 10.3 7.3 0.53 10.3 2.1 2.4 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ORX69111.1 - 3.8 7.5 9.9 3.6 7.6 2.0 2.4 2 1 0 2 2 2 0 zinc-finger of a C2HC-type Glyco_transf_15 PF01793.16 ORX69113.1 - 6.5e-61 206.4 4.5 1.4e-60 205.2 4.5 1.5 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Phage_Coat_A PF05357.13 ORX69113.1 - 0.11 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Phage Coat Protein A OPT PF03169.15 ORX69115.1 - 4.2e-136 455.1 45.1 4.7e-136 454.9 45.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Fas_alpha_ACP PF18325.1 ORX69116.1 - 1.1e-41 142.9 0.0 2e-41 142.0 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX69116.1 - 3.1e-24 85.7 0.0 6.5e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ORX69116.1 - 3.1e-06 27.0 2.4 1.2e-05 25.0 0.6 2.5 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX69116.1 - 0.00032 20.7 0.0 0.0013 18.7 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain AdoHcyase_NAD PF00670.21 ORX69116.1 - 0.2 11.7 0.4 4.4 7.4 0.3 2.3 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acyl_transf_1 PF00698.21 ORX69117.1 - 9.4e-07 28.6 0.0 1.3e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain DUF1729 PF08354.10 ORX69118.1 - 3.9e-36 124.7 0.0 8.9e-19 67.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1729) FAS_meander PF17951.1 ORX69118.1 - 1e-20 74.1 0.0 2.4e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX69118.1 - 1.2e-10 41.6 0.0 3.6e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ORX69118.1 - 0.034 14.2 0.1 0.069 13.2 0.1 1.5 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta Ribosomal_L27A PF00828.19 ORX69119.1 - 1.8e-36 125.6 0.2 3.6e-36 124.6 0.1 1.5 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A LepB_GAP_N PF18172.1 ORX69120.1 - 0.16 11.8 0.2 0.28 11.0 0.2 1.3 1 0 0 1 1 1 0 LepB GAP domain N-terminal subdomain TPR_14 PF13428.6 ORX69122.1 - 3.3e-25 86.6 46.3 0.0001 22.8 1.0 12.5 6 5 7 13 13 13 7 Tetratricopeptide repeat HAT PF02184.16 ORX69122.1 - 2.4e-23 81.7 59.7 9e-10 38.3 0.2 13.9 13 2 0 13 13 13 6 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 ORX69122.1 - 1.8e-21 76.4 11.7 0.002 18.6 0.0 7.8 6 1 0 7 7 7 6 Tetratricopeptide repeat Suf PF05843.14 ORX69122.1 - 9e-15 55.4 15.2 6.9e-07 29.5 1.8 5.8 2 2 2 5 5 5 3 Suppressor of forked protein (Suf) U3_assoc_6 PF08640.11 ORX69122.1 - 1.4e-05 25.1 16.2 0.14 12.3 0.2 5.5 4 1 1 5 5 5 3 U3 small nucleolar RNA-associated protein 6 TPR_2 PF07719.17 ORX69122.1 - 0.0001 22.1 19.1 9.7 6.6 0.0 9.6 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69122.1 - 0.00041 20.9 34.2 0.22 12.2 0.0 8.2 6 2 3 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX69122.1 - 0.00068 19.8 12.4 20 5.9 0.0 8.3 10 1 0 10 10 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX69122.1 - 0.0023 18.5 23.6 10 7.0 0.0 10.6 12 0 0 12 12 12 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ORX69122.1 - 0.014 15.4 20.8 0.65 10.0 1.5 6.6 5 2 0 5 5 5 0 Mad3/BUB1 homology region 1 TPR_7 PF13176.6 ORX69122.1 - 0.017 15.1 9.1 44 4.4 0.3 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Babuvirus_MP PF07234.11 ORX69122.1 - 1.5 9.0 4.2 9.1 6.5 0.5 3.3 3 0 0 3 3 3 0 Movement and RNA silencing protein Arrestin_N PF00339.29 ORX69123.1 - 1.2e-07 31.9 0.0 2.1e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX69123.1 - 4e-05 23.4 1.0 0.00022 21.0 0.0 2.5 2 1 1 3 3 3 1 Arrestin_N terminal like Arrestin_C PF02752.22 ORX69123.1 - 9.7e-05 22.8 0.0 0.0081 16.6 0.0 2.8 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain PAP_assoc PF03828.19 ORX69124.1 - 3.1e-10 40.1 0.0 7.5e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX69124.1 - 0.00059 20.1 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF4269 PF14091.6 ORX69124.1 - 0.053 13.8 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) Polbeta PF18765.1 ORX69124.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Trehalase PF01204.18 ORX69125.1 - 3.2e-117 392.5 0.5 1.1e-58 199.4 0.0 2.8 1 1 1 2 2 2 2 Trehalase GDE_C PF06202.14 ORX69125.1 - 3.2e-06 26.4 0.2 8.4e-06 25.0 0.2 1.5 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase SLC35F PF06027.12 ORX69127.1 - 3.4e-65 220.5 20.8 5e-62 210.1 20.8 3.1 1 1 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 ORX69127.1 - 0.024 14.8 0.7 0.024 14.8 0.7 3.9 2 2 1 3 3 3 0 EamA-like transporter family DMT_YdcZ PF04657.13 ORX69127.1 - 9 6.6 11.3 2.9 8.2 0.5 2.9 2 1 1 3 3 3 0 Putative inner membrane exporter, YdcZ zf-Di19 PF05605.12 ORX69128.1 - 0.0014 18.9 2.0 0.0022 18.2 2.0 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 ORX69128.1 - 0.0045 17.3 0.6 0.0046 17.3 0.6 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) UBA PF00627.31 ORX69129.1 - 7.4e-10 38.5 0.6 1.2e-09 37.9 0.6 1.4 1 0 0 1 1 1 1 UBA/TS-N domain STI1 PF17830.1 ORX69129.1 - 0.0066 16.4 8.4 0.018 15.0 8.4 1.7 1 0 0 1 1 1 1 STI1 domain HOIP-UBA PF16678.5 ORX69129.1 - 0.0099 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 HOIP UBA domain pair CUE PF02845.16 ORX69129.1 - 0.16 11.7 2.6 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 CUE domain Epimerase PF01370.21 ORX69131.1 - 0.1 12.1 0.2 8.7 5.7 0.0 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 ORX69133.1 - 2.2e-19 70.2 0.1 3.3e-19 69.6 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ORX69133.1 - 1e-11 45.1 0.0 2.2e-11 44.1 0.0 1.6 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ORX69133.1 - 2.1e-06 28.2 0.1 5.1e-06 27.0 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ORX69133.1 - 0.0014 18.7 0.1 0.0023 18.0 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ORX69133.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Rossmann-like PF10727.9 ORX69133.1 - 0.015 15.2 0.3 0.035 13.9 0.3 1.7 1 0 0 1 1 1 0 Rossmann-like domain IlvN PF07991.12 ORX69133.1 - 0.044 13.4 0.1 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain PhyH PF05721.13 ORX69134.1 - 4.2e-51 174.2 0.0 5.3e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HTH_AraC PF00165.23 ORX69134.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family RPN2_C PF18004.1 ORX69137.1 - 0.043 13.7 0.2 0.074 13.0 0.2 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF3464 PF11947.8 ORX69137.1 - 0.61 9.8 3.4 0.36 10.6 0.2 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 IKI3 PF04762.12 ORX69138.1 - 3.2e-227 756.9 0.0 1.5e-121 407.2 0.0 3.1 1 1 1 2 2 2 2 IKI3 family ANAPC4_WD40 PF12894.7 ORX69138.1 - 0.0018 18.6 0.3 3.7 7.9 0.0 4.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PBS_linker_poly PF00427.21 ORX69138.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.7 2 0 0 2 2 2 0 Phycobilisome Linker polypeptide tRNA-synt_1 PF00133.22 ORX69139.1 - 3.9e-220 732.2 0.0 6.1e-220 731.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX69139.1 - 2.8e-14 53.3 0.0 2.1e-13 50.5 0.0 2.2 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX69139.1 - 6.5e-13 48.2 1.3 6.1e-05 21.9 0.3 3.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ORX69139.1 - 0.00064 19.2 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain PCI PF01399.27 ORX69140.1 - 8.6e-10 39.1 0.0 4.4e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 ORX69140.1 - 2e-09 37.0 0.9 4.9e-09 35.7 0.9 1.8 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix Npun_R1517 PF18068.1 ORX69140.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.9 1 0 0 1 1 1 0 Npun R1517 MnmE_helical PF12631.7 ORX69141.1 - 0.0082 16.3 0.5 0.0092 16.2 0.5 1.2 1 0 0 1 1 1 1 MnmE helical domain Phage_GP20 PF06810.11 ORX69141.1 - 0.029 14.2 5.9 0.035 13.9 5.9 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 Exonuc_VII_L PF02601.15 ORX69141.1 - 0.16 11.5 7.8 0.16 11.5 7.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 ORX69141.1 - 0.27 9.1 2.4 0.27 9.1 2.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ORX69141.1 - 3.2 5.9 9.9 3.8 5.7 9.9 1.0 1 0 0 1 1 1 0 CDC45-like protein TMPIT PF07851.13 ORX69141.1 - 4.2 6.5 5.4 5.2 6.2 5.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.9 ORX69141.1 - 6.4 5.8 17.7 9.8 5.2 16.6 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PheRS_DBD1 PF18552.1 ORX69143.1 - 0.054 13.3 0.2 0.089 12.6 0.2 1.3 1 0 0 1 1 1 0 PheRS DNA binding domain 1 JmjC PF02373.22 ORX69144.1 - 1.2e-09 38.6 0.0 2.2e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ORX69144.1 - 0.018 14.7 0.0 0.034 13.8 0.0 1.5 1 1 0 1 1 1 0 Cupin-like domain Cupin_2 PF07883.11 ORX69144.1 - 0.19 11.5 0.0 0.58 9.9 0.0 1.7 2 0 0 2 2 2 0 Cupin domain Nic96 PF04097.14 ORX69145.1 - 8.5e-130 434.1 0.1 1.2e-129 433.7 0.1 1.1 1 0 0 1 1 1 1 Nup93/Nic96 DUF993 PF06187.11 ORX69145.1 - 0.013 14.5 0.2 0.03 13.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF993) Remorin_C PF03763.13 ORX69146.1 - 0.0071 16.2 2.8 0.0099 15.7 2.8 1.1 1 0 0 1 1 1 1 Remorin, C-terminal region p450 PF00067.22 ORX69147.1 - 5.6e-49 167.1 0.0 3.2e-43 148.1 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 Transferase PF02458.15 ORX69148.1 - 2.1e-16 59.6 0.0 3.6e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Transferase family DUF1877 PF08974.10 ORX69149.1 - 0.079 13.0 0.7 0.3 11.2 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) FHA PF00498.26 ORX69150.1 - 3.5e-12 46.5 0.2 6.8e-12 45.6 0.2 1.5 1 0 0 1 1 1 1 FHA domain PP1_bind PF15276.6 ORX69150.1 - 1.3e-09 38.2 2.3 1.3e-09 38.2 2.3 2.7 3 0 0 3 3 3 1 Protein phosphatase 1 binding Yop-YscD_cpl PF16697.5 ORX69150.1 - 1.6e-08 34.7 0.0 3.7e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 ORX69150.1 - 0.047 13.9 0.1 0.09 13.0 0.1 1.4 1 0 0 1 1 1 0 FHA domain UQ_con PF00179.26 ORX69151.1 - 2e-34 118.3 0.0 2.5e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ORX69151.1 - 0.079 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain MIS13 PF08202.11 ORX69152.1 - 3.5e-32 111.9 1.8 5.5e-32 111.3 1.8 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Lipase_GDSL_2 PF13472.6 ORX69154.1 - 9.7e-23 81.5 1.6 1.6e-22 80.8 1.6 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX69154.1 - 1.4e-17 64.3 0.0 1.7e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF2428 PF10350.9 ORX69155.1 - 3.8e-42 144.5 0.0 1.9e-40 138.9 0.0 2.5 1 1 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) rRNA_proc-arch PF13234.6 ORX69156.1 - 1.3e-47 163.0 1.6 1.3e-40 140.1 0.0 2.4 1 1 1 2 2 2 2 rRNA-processing arch domain DEAD PF00270.29 ORX69156.1 - 3.1e-21 75.9 0.1 3.3e-20 72.6 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase DSHCT PF08148.12 ORX69156.1 - 5.6e-21 74.9 1.4 6.8e-20 71.4 1.4 2.7 1 1 0 1 1 1 1 DSHCT (NUC185) domain Helicase_C PF00271.31 ORX69156.1 - 1.1e-06 28.9 0.0 1.5e-05 25.3 0.0 2.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX69156.1 - 1.4e-05 25.2 0.0 4.6e-05 23.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ABC_tran_CTD PF16326.5 ORX69156.1 - 0.34 11.2 7.0 1.3 9.4 0.1 3.4 3 0 0 3 3 3 0 ABC transporter C-terminal domain FMN_red PF03358.15 ORX69157.1 - 3e-10 40.1 0.0 4e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX69157.1 - 2.1e-06 27.6 0.0 2.5e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ORX69157.1 - 0.084 13.1 0.0 0.4 10.9 0.0 1.9 1 1 1 2 2 2 0 Flavodoxin domain Transket_pyr PF02779.24 ORX69158.1 - 1.3e-44 152.0 0.1 1.9e-44 151.5 0.1 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX69158.1 - 1e-30 106.2 0.1 2.1e-30 105.2 0.0 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain Glyco_tran_WecB PF03808.13 ORX69158.1 - 0.044 13.7 0.0 0.16 11.9 0.0 1.9 2 1 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Thiamine_BP PF01910.17 ORX69158.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Thiamine-binding protein FMN_red PF03358.15 ORX69159.1 - 1.7e-13 50.6 0.0 2.9e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX69159.1 - 4.4e-08 33.1 0.0 6.7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX69159.1 - 3.2e-05 24.2 0.0 5.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin SspP PF08179.12 ORX69159.1 - 0.021 15.3 0.9 0.021 15.3 0.9 1.7 2 0 0 2 2 2 0 Small acid-soluble spore protein P family Actin PF00022.19 ORX69160.1 - 8.1e-34 116.9 0.0 2.1e-21 76.0 0.0 3.1 2 1 0 2 2 2 2 Actin OPT PF03169.15 ORX69161.1 - 2.6e-144 482.2 43.4 2.9e-144 482.0 43.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Ldh_1_N PF00056.23 ORX69162.1 - 7e-36 123.4 0.3 1.1e-35 122.8 0.3 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ORX69162.1 - 6.3e-21 75.0 0.1 1.4e-20 73.9 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Helicase_C_2 PF13307.6 ORX69163.1 - 3.7e-52 176.9 0.2 1.3e-51 175.2 0.0 2.1 3 0 0 3 3 3 1 Helicase C-terminal domain DEAD_2 PF06733.15 ORX69163.1 - 1.7e-43 148.3 0.1 5.3e-43 146.7 0.0 1.8 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 ORX69163.1 - 0.0018 18.0 0.1 0.047 13.5 0.2 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX69163.1 - 0.0067 16.4 0.0 1 9.3 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX69163.1 - 0.027 13.9 0.3 7.5 5.9 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein DUF1635 PF07795.11 ORX69163.1 - 0.15 11.9 1.4 0.4 10.5 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) UCH_1 PF13423.6 ORX69164.1 - 1.8e-62 211.8 0.0 2.3e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 ORX69164.1 - 2.2e-14 54.3 0.0 3.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 ORX69164.1 - 0.00018 21.1 0.0 0.54 9.7 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.25 ORX69165.1 - 2.9e-14 53.1 0.0 4.4e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ORX69165.1 - 1.5e-07 31.0 0.0 2.3e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX69165.1 - 2.3e-06 27.7 0.1 3.5e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX69165.1 - 3.8e-05 23.4 0.1 5.5e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX69165.1 - 5.9e-05 22.0 0.0 6.6e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ORX69165.1 - 0.0012 18.2 0.0 0.0042 16.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ORX69165.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 ORX69165.1 - 0.053 12.6 0.1 0.077 12.0 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 EcKinase PF02958.20 ORX69165.1 - 0.094 12.0 0.1 0.86 8.8 0.0 2.2 1 1 1 2 2 2 0 Ecdysteroid kinase Kinase-like PF14531.6 ORX69165.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like ATP11 PF06644.11 ORX69166.1 - 1.4e-73 248.1 6.0 1.5e-73 247.9 6.0 1.0 1 0 0 1 1 1 1 ATP11 protein Plasmodium_Vir PF05795.11 ORX69166.1 - 0.037 13.5 1.9 0.048 13.1 1.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ndc1_Nup PF09531.10 ORX69166.1 - 0.086 11.5 1.3 0.095 11.4 1.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAP_assoc PF03828.19 ORX69167.1 - 2e-17 63.2 0.1 4.5e-17 62.0 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX69167.1 - 2.5e-08 34.1 0.0 5.5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ORX69167.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase PseudoU_synth_2 PF00849.22 ORX69168.1 - 2.8e-28 99.0 0.0 4e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ORX69168.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 S4 domain TFIID-18kDa PF02269.16 ORX69171.1 - 1.9e-32 111.1 0.8 3.9e-32 110.1 0.8 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIIE-A_C PF11521.8 ORX69171.1 - 0.0073 16.6 3.2 0.0073 16.6 3.2 2.0 2 0 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha Peptidase_M36 PF02128.15 ORX69172.1 - 1.6e-28 99.9 0.0 1.9e-28 99.7 0.0 1.0 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) RFX_DNA_binding PF02257.15 ORX69173.1 - 0.077 13.6 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 RFX DNA-binding domain FOXP-CC PF16159.5 ORX69173.1 - 2.8 8.6 6.2 2.9 8.6 0.5 2.9 1 1 1 2 2 2 0 FOXP coiled-coil domain Aquarius_N PF16399.5 ORX69174.1 - 1.7e-187 625.1 0.4 2e-186 621.5 0.4 2.1 1 1 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 ORX69174.1 - 2.2e-31 109.6 0.1 1.2e-30 107.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ORX69174.1 - 3.8e-27 95.2 0.0 1.9e-26 92.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX69174.1 - 5.4e-12 46.3 0.0 3.1e-11 43.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX69174.1 - 2.7e-11 43.5 0.1 7.9e-05 22.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 ORX69174.1 - 4.4e-07 30.1 0.0 1.1e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 ORX69174.1 - 0.00035 20.3 0.6 0.00084 19.1 0.6 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 ORX69174.1 - 0.0004 20.0 0.0 0.00084 18.9 0.0 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 ORX69174.1 - 0.003 17.0 0.1 0.016 14.6 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 ORX69174.1 - 0.0048 17.2 0.1 0.048 13.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 ORX69174.1 - 0.0048 16.7 0.0 0.79 9.4 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 ORX69174.1 - 0.016 15.6 0.0 0.086 13.3 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX69174.1 - 0.042 14.2 0.0 0.14 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain DEAD PF00270.29 ORX69174.1 - 0.047 13.5 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF2075 PF09848.9 ORX69174.1 - 0.053 12.7 0.0 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ORX69174.1 - 0.072 12.6 0.4 0.26 10.8 0.0 2.1 3 0 0 3 3 3 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 ORX69174.1 - 0.076 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 KHA PF11834.8 ORX69174.1 - 0.098 12.8 0.1 0.7 10.0 0.0 2.5 3 0 0 3 3 2 0 KHA, dimerisation domain of potassium ion channel DnaB_C PF03796.15 ORX69174.1 - 0.11 11.8 0.0 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Adeno_IVa2 PF02456.15 ORX69174.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein QRPTase_N PF02749.16 ORX69179.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, N-terminal domain AA_permease PF00324.21 ORX69181.1 - 8.4e-118 394.0 42.2 1.1e-117 393.7 42.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX69181.1 - 7.1e-36 123.9 43.7 8.7e-36 123.7 43.7 1.1 1 0 0 1 1 1 1 Amino acid permease RRM_1 PF00076.22 ORX69182.1 - 1.3e-27 95.4 0.0 1.1e-14 54.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX69182.1 - 0.0021 18.1 0.1 0.12 12.4 0.0 2.4 2 0 0 2 2 2 1 Limkain b1 DbpA PF03880.15 ORX69182.1 - 0.014 15.4 0.0 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Calcipressin PF04847.12 ORX69182.1 - 0.083 12.6 0.1 8.5 6.1 0.0 2.5 3 0 0 3 3 3 0 Calcipressin RRM_7 PF16367.5 ORX69182.1 - 0.094 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 ORX69182.1 - 0.11 12.4 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif Mito_carr PF00153.27 ORX69185.1 - 0.15 12.0 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial carrier protein AAA PF00004.29 ORX69187.1 - 1.7e-40 138.5 0.0 4.4e-40 137.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ORX69187.1 - 2.6e-19 68.9 0.1 5.4e-19 67.9 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ORX69187.1 - 9.1e-11 41.4 0.2 2e-10 40.3 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ORX69187.1 - 1.3e-05 25.7 0.2 0.0068 16.8 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX69187.1 - 1.8e-05 24.7 0.0 7.6e-05 22.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX69187.1 - 0.00014 21.6 0.0 0.00039 20.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX69187.1 - 0.0005 20.2 0.0 0.0028 17.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX69187.1 - 0.00065 20.0 0.4 0.064 13.5 0.0 2.5 1 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 ORX69187.1 - 0.0028 16.9 0.0 0.0052 16.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) PhoH PF02562.16 ORX69187.1 - 0.0029 17.1 0.1 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 ORX69187.1 - 0.004 17.3 0.0 0.012 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ORX69187.1 - 0.0056 16.1 0.1 0.015 14.7 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ORX69187.1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 ORX69187.1 - 0.041 13.4 0.0 0.1 12.1 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 ORX69187.1 - 0.042 14.2 0.0 0.098 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ORX69187.1 - 0.065 12.4 0.5 0.59 9.3 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain RNA_helicase PF00910.22 ORX69187.1 - 0.069 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 ORX69187.1 - 0.073 12.8 0.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 ORX69187.1 - 0.076 12.7 0.1 0.24 11.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ORX69187.1 - 0.083 12.7 0.5 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ORX69187.1 - 0.12 11.7 1.3 0.18 11.1 0.0 1.9 3 0 0 3 3 3 0 KaiC Zeta_toxin PF06414.12 ORX69187.1 - 0.17 11.1 1.6 0.27 10.5 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin JAB PF01398.21 ORX69188.1 - 4.5e-24 84.7 0.0 8.8e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ORX69188.1 - 5e-13 49.4 0.7 1.1e-12 48.3 0.7 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function TACC_C PF05010.14 ORX69188.1 - 0.12 12.1 0.1 0.78 9.5 0.1 1.9 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal WD40 PF00400.32 ORX69189.1 - 0.00021 22.0 0.1 0.73 10.8 0.1 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat RICTOR_M PF14666.6 ORX69190.1 - 2.3e-18 65.9 0.0 2.5e-16 59.3 0.0 3.5 2 2 2 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 ORX69190.1 - 4.1e-16 59.0 0.9 4.1e-15 55.8 0.5 2.9 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RICTOR_N PF14664.6 ORX69190.1 - 7.2e-14 51.6 1.4 2.8e-05 23.3 0.1 4.6 3 1 1 4 4 4 3 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 ORX69190.1 - 8.3e-11 42.3 0.0 1e-08 35.5 0.0 3.6 2 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_2 PF13646.6 ORX69190.1 - 0.0019 18.6 0.5 1.9 8.9 0.0 3.7 3 1 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 ORX69190.1 - 0.0048 17.4 1.5 0.44 11.1 0.1 3.9 3 1 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 ORX69190.1 - 0.0097 16.1 0.2 0.07 13.4 0.1 2.6 2 0 0 2 2 2 1 HEAT repeat Noggin PF05806.12 ORX69191.1 - 0.044 13.7 0.3 0.056 13.3 0.3 1.1 1 0 0 1 1 1 0 Noggin C2 PF00168.30 ORX69192.1 - 2.1e-06 27.9 0.0 3.3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain Microvir_J PF04726.13 ORX69192.1 - 0.092 12.7 3.8 0.57 10.2 1.7 2.5 1 1 1 2 2 2 0 Microvirus J protein Velvet PF11754.8 ORX69193.1 - 9.3e-53 179.7 0.2 1.8e-32 113.3 0.0 2.0 1 1 1 2 2 2 2 Velvet factor G-alpha PF00503.20 ORX69195.1 - 1.7e-124 415.6 1.4 2e-124 415.4 1.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX69195.1 - 6.1e-14 51.8 1.2 2e-09 37.1 0.3 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX69195.1 - 0.00029 20.3 4.1 0.0087 15.4 0.1 2.8 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region zf-CHC2 PF01807.20 ORX69195.1 - 0.01 15.6 0.0 0.037 13.8 0.0 1.9 2 0 0 2 2 2 0 CHC2 zinc finger AAA_29 PF13555.6 ORX69195.1 - 0.01 15.5 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX69195.1 - 0.018 15.1 0.0 2.1 8.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ORX69195.1 - 0.044 14.0 0.2 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Aldo_ket_red PF00248.21 ORX69196.1 - 8.3e-06 25.2 0.0 1.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family EIF_2_alpha PF07541.12 ORX69197.1 - 8e-32 109.8 0.1 8.1e-31 106.5 0.1 2.2 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ORX69197.1 - 6.3e-14 52.1 3.0 1.1e-13 51.2 3.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain Amidohydro_1 PF01979.20 ORX69197.1 - 0.0065 15.8 0.7 0.0098 15.2 0.7 1.2 1 0 0 1 1 1 1 Amidohydrolase family UBX PF00789.20 ORX69197.1 - 0.01 16.0 0.0 0.036 14.3 0.0 1.9 2 0 0 2 2 2 0 UBX domain Pex24p PF06398.11 ORX69198.1 - 2.4e-37 128.8 0.1 4.7e-37 127.8 0.1 1.4 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin C1_1 PF00130.22 ORX69198.1 - 1.2e-11 44.3 4.9 2e-11 43.6 4.9 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 ORX69198.1 - 0.3 11.1 3.0 0.59 10.1 3.0 1.5 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon DZR PF12773.7 ORX69198.1 - 0.76 9.9 5.1 1.4 9.0 5.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon PHD PF00628.29 ORX69198.1 - 1.1 9.2 4.6 2 8.4 4.6 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 ORX69198.1 - 1.5 9.2 6.6 3 8.2 6.6 1.5 1 0 0 1 1 1 0 RING-like domain RhoGAP PF00620.27 ORX69200.1 - 1.1e-35 122.8 0.0 1.5e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain SNF2_N PF00176.23 ORX69202.1 - 4e-63 213.3 0.0 7.4e-63 212.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3535 PF12054.8 ORX69202.1 - 8.7e-63 213.1 7.4 8.7e-63 213.1 7.4 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) Helicase_C PF00271.31 ORX69202.1 - 8.1e-17 61.6 0.0 2.5e-16 60.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 ORX69202.1 - 1.2e-15 56.3 12.7 0.77 10.2 0.5 9.9 8 1 1 9 9 9 6 HEAT repeat HEAT_2 PF13646.6 ORX69202.1 - 3.3e-07 30.6 14.7 0.00056 20.3 0.0 7.2 7 1 1 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX69202.1 - 3.8e-05 24.2 0.1 0.038 14.6 0.0 4.5 5 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ORX69202.1 - 0.72 10.4 19.6 1.4 9.5 0.1 8.0 8 1 1 9 9 9 0 HEAT-like repeat Sterol_MT_C PF08498.10 ORX69203.1 - 3.7e-25 88.0 0.1 6.4e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 ORX69203.1 - 6.4e-21 74.8 0.0 1.2e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX69203.1 - 4.4e-18 65.5 0.0 8.1e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX69203.1 - 2.1e-17 63.4 0.1 6.5e-17 61.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX69203.1 - 2.5e-17 63.4 0.0 5.3e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX69203.1 - 2.7e-12 46.6 0.1 3.8e-12 46.1 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 ORX69203.1 - 9.8e-11 42.3 0.0 2.1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX69203.1 - 7.1e-08 32.1 0.0 1.1e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 ORX69203.1 - 0.00017 21.1 0.0 0.00036 20.0 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 ORX69203.1 - 0.00023 20.6 0.0 0.00041 19.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX69203.1 - 0.0024 17.5 0.0 0.0057 16.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ORX69203.1 - 0.024 14.4 0.1 0.068 12.9 0.1 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Erp_C PF06780.11 ORX69203.1 - 0.048 13.7 0.3 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 Erp protein C-terminus Methyltransf_29 PF03141.16 ORX69203.1 - 0.11 11.0 0.0 0.23 10.0 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Fic PF02661.18 ORX69205.1 - 0.056 14.3 0.1 0.1 13.5 0.1 1.3 1 1 0 1 1 1 0 Fic/DOC family Complex1_LYR PF05347.15 ORX69206.1 - 1.6e-15 56.8 1.1 2.1e-15 56.5 1.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX69206.1 - 0.0077 17.0 0.4 0.011 16.5 0.4 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Phage_lysozyme PF00959.19 ORX69208.1 - 2.7e-05 24.6 0.0 3.2e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme ApbA PF02558.16 ORX69208.1 - 0.045 13.4 0.0 0.05 13.3 0.0 1.0 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Cation_efflux PF01545.21 ORX69209.1 - 5.7e-48 163.3 0.8 8.3e-48 162.8 0.8 1.2 1 0 0 1 1 1 1 Cation efflux family DUF2871 PF11070.8 ORX69209.1 - 0.13 12.5 2.5 5.6 7.3 2.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2871) Herpes_UL35 PF04496.12 ORX69209.1 - 0.22 11.9 0.8 0.47 10.8 0.1 1.9 2 0 0 2 2 2 0 Herpesvirus UL35 family CRAL_TRIO PF00650.20 ORX69211.1 - 0.0022 17.8 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF4592 PF15262.6 ORX69211.1 - 0.55 10.9 4.6 0.52 11.0 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4592) GTP_cyclohydro2 PF00925.20 ORX69212.1 - 8e-62 207.6 0.0 1.2e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II zf-CCCH_4 PF18044.1 ORX69213.1 - 3.4e-05 23.5 4.4 6.9e-05 22.5 4.4 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX69213.1 - 4.7e-05 23.3 4.8 9e-05 22.4 4.8 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ORX69213.1 - 0.00063 19.6 2.7 0.0011 18.8 2.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SUIM_assoc PF16619.5 ORX69213.1 - 1.7 8.8 7.1 2.2 8.4 3.9 2.7 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-CCCH_2 PF14608.6 ORX69213.1 - 1.7 9.2 3.9 3.1 8.4 3.9 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger WD40 PF00400.32 ORX69214.1 - 0.0036 18.1 0.0 4.4 8.3 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ORX69214.1 - 0.045 12.7 0.1 6.2 5.7 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TRIC PF05197.13 ORX69215.1 - 5.5e-12 45.7 0.0 9.7e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 ORX69215.1 - 0.096 12.6 1.9 0.28 11.1 0.2 2.3 2 0 0 2 2 2 0 UPF0126 domain FAM176 PF14851.6 ORX69215.1 - 1.8 8.2 4.7 7.7 6.2 4.6 1.9 2 0 0 2 2 2 0 FAM176 family E1_DerP2_DerF2 PF02221.15 ORX69216.1 - 2.3e-14 54.0 0.0 2.9e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 ORX69216.1 - 0.0028 18.0 0.0 0.004 17.5 0.0 1.2 1 0 0 1 1 1 1 ML-like domain DUF1091 PF06477.13 ORX69216.1 - 0.078 13.5 0.2 0.23 12.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1091) CHCH PF06747.13 ORX69217.1 - 2.5e-06 27.4 2.3 3.4e-06 27.1 2.3 1.2 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 ORX69217.1 - 0.0077 16.5 1.6 0.011 16.1 1.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 ORX69217.1 - 0.037 13.8 0.3 0.048 13.4 0.3 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Methyltr_RsmB-F PF01189.17 ORX69218.1 - 2.7e-72 242.6 0.0 4.8e-72 241.8 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ORX69218.1 - 1.1e-09 38.6 0.0 2.7e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 ORX69218.1 - 7.4e-05 22.6 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 ORX69218.1 - 0.0047 16.7 0.0 0.0084 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ORX69218.1 - 0.045 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase BUD22 PF09073.10 ORX69218.1 - 1.6 8.0 27.8 2.6 7.3 27.8 1.3 1 0 0 1 1 1 0 BUD22 Dicty_REP PF05086.12 ORX69218.1 - 4.9 5.0 5.9 7.4 4.4 5.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Oxidored_FMN PF00724.20 ORX69220.1 - 4.1e-67 226.9 0.0 5e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MCM PF00493.23 ORX69223.1 - 1.5e-88 295.6 0.0 2.8e-88 294.8 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX69223.1 - 1.2e-36 125.3 0.1 2.4e-36 124.4 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX69223.1 - 5.3e-27 94.1 1.4 5.3e-27 94.1 1.4 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain MCM2_N PF12619.8 ORX69223.1 - 1.4e-18 67.7 25.7 2.3e-18 67.0 23.4 2.4 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 ORX69223.1 - 2.4e-13 50.6 0.0 6.8e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX69223.1 - 1.3e-07 31.2 0.0 5e-06 26.0 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX69223.1 - 2.1e-05 24.5 0.0 5.3e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ORX69223.1 - 0.00011 22.1 0.0 0.00067 19.5 0.0 2.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 ORX69223.1 - 0.0022 17.8 1.1 0.0083 15.9 1.1 2.0 1 0 0 1 1 1 1 AAA lid domain Yippee-Mis18 PF03226.14 ORX69223.1 - 0.11 12.7 0.2 0.24 11.6 0.2 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Sigma54_activat PF00158.26 ORX69223.1 - 0.13 11.9 0.1 1.6 8.4 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain LIM PF00412.22 ORX69224.1 - 7.2e-26 90.2 38.9 4e-11 43.0 7.9 4.0 4 0 0 4 4 4 3 LIM domain DnaJ PF00226.31 ORX69225.1 - 7.9e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 ORX69225.1 - 9.9e-05 22.4 0.0 0.00011 22.2 0.0 1.2 1 0 0 1 1 1 1 Pam16 Methyltransf_15 PF09445.10 ORX69226.1 - 8.1e-39 132.8 0.0 1e-38 132.5 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 ORX69226.1 - 1.1e-08 35.6 0.0 1.8e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX69226.1 - 1.7e-06 27.9 0.0 2.2e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ORX69226.1 - 2e-06 27.7 0.0 2.6e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 ORX69226.1 - 4.4e-06 26.5 0.0 1.4e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 ORX69226.1 - 0.00015 21.7 0.0 0.00027 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX69226.1 - 0.00018 21.2 0.0 0.00024 20.8 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX69226.1 - 0.0002 22.0 0.0 0.00032 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX69226.1 - 0.00073 19.1 0.0 0.00097 18.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain TrmK PF04816.12 ORX69226.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 1 1 2 2 2 0 tRNA (adenine(22)-N(1))-methyltransferase PrmA PF06325.13 ORX69226.1 - 0.026 13.9 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.17 ORX69226.1 - 0.076 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase TRM PF02005.16 ORX69226.1 - 0.17 11.0 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_23 PF13489.6 ORX69226.1 - 0.19 11.6 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Cu-oxidase PF00394.22 ORX69227.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.7 1 1 1 2 2 2 0 Multicopper oxidase Use1 PF09753.9 ORX69228.1 - 4.1e-24 85.7 5.0 1.5e-23 83.8 5.0 1.8 1 1 0 1 1 1 1 Membrane fusion protein Use1 Muted PF14942.6 ORX69228.1 - 0.0069 16.7 3.2 0.17 12.3 1.0 2.1 2 0 0 2 2 2 2 Organelle biogenesis, Muted-like protein Tweety PF04906.13 ORX69228.1 - 0.028 13.1 0.0 0.045 12.4 0.0 1.2 1 0 0 1 1 1 0 Tweety DUF305 PF03713.13 ORX69228.1 - 0.047 13.8 3.4 0.11 12.7 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF305) TFIIA PF03153.13 ORX69230.1 - 0.0031 17.6 24.8 0.0038 17.3 24.8 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 ORX69230.1 - 0.88 8.6 8.3 1.2 8.1 8.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DcuA_DcuB PF03605.14 ORX69230.1 - 1.2 7.9 5.8 1.6 7.6 5.8 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter GET2 PF08690.10 ORX69230.1 - 1.4 8.6 11.9 2 8.0 11.9 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 CCSAP PF15748.5 ORX69230.1 - 1.6 8.9 16.5 2.2 8.4 16.5 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Dicty_REP PF05086.12 ORX69230.1 - 2.6 5.9 10.4 3.3 5.6 10.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FAM199X PF15814.5 ORX69230.1 - 3.6 6.5 9.9 5 6.1 9.9 1.3 1 0 0 1 1 1 0 Protein family FAM199X DUF4407 PF14362.6 ORX69230.1 - 5.8 6.2 12.2 7.3 5.9 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RAB3GAP2_N PF14655.6 ORX69230.1 - 7 5.8 11.8 3 7.0 9.6 1.4 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF3533 PF12051.8 ORX69230.1 - 9.7 5.0 7.1 10 5.0 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Pkinase PF00069.25 ORX69231.1 - 1.3e-52 178.8 0.0 2.7e-52 177.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69231.1 - 3e-21 75.9 0.0 5.4e-21 75.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX69231.1 - 0.0034 17.3 1.1 1 9.2 0.2 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX69231.1 - 0.0055 16.0 2.0 0.043 13.1 0.2 2.7 3 1 0 3 3 3 1 Kinase-like Kdo PF06293.14 ORX69231.1 - 0.011 15.1 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX69231.1 - 0.032 13.8 0.0 0.078 12.6 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Methyltransf_16 PF10294.9 ORX69232.1 - 6.8e-13 48.7 0.0 8.2e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase RIO1 PF01163.22 ORX69233.1 - 2.2e-73 245.9 0.5 3.4e-73 245.3 0.5 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 ORX69233.1 - 0.00044 19.7 0.1 0.00085 18.8 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ORX69233.1 - 0.0032 16.8 0.8 0.059 12.7 0.8 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX69233.1 - 0.028 14.3 0.0 10 5.9 0.0 2.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Tim54 PF11711.8 ORX69234.1 - 9.8e-07 27.9 0.1 1.3e-06 27.5 0.1 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Yae1_N PF09811.9 ORX69235.1 - 0.07 12.8 1.8 0.07 12.8 1.8 1.9 2 0 0 2 2 2 0 Essential protein Yae1, N terminal SET PF00856.28 ORX69236.1 - 0.0019 18.6 0.0 0.0053 17.2 0.0 1.9 1 1 0 1 1 1 1 SET domain Prefoldin PF02996.17 ORX69237.1 - 3.3e-19 69.0 0.2 3.8e-19 68.8 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit zf-C4H2 PF10146.9 ORX69237.1 - 0.1 12.9 1.1 4.7 7.4 0.0 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein Spore_II_R PF09551.10 ORX69237.1 - 0.15 12.5 0.9 9.9 6.6 0.1 2.1 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) Pro_isomerase PF00160.21 ORX69238.1 - 3.3e-48 163.9 0.3 3.7e-48 163.8 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DNA_pol_B_palm PF14792.6 ORX69239.1 - 0.18 12.0 0.1 0.37 11.0 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase beta palm Sdh_cyt PF01127.22 ORX69240.1 - 1e-18 67.5 2.4 1.2e-18 67.3 2.4 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DAGAT PF03982.13 ORX69241.1 - 5.4e-62 209.4 0.0 1.5e-61 208.0 0.0 1.6 1 1 0 1 1 1 1 Diacylglycerol acyltransferase Mpv17_PMP22 PF04117.12 ORX69242.1 - 5.5e-17 61.7 0.0 1e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family DHHC PF01529.20 ORX69243.1 - 1.8e-37 128.4 9.7 1.8e-37 128.4 9.7 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase Chordopox_A20R PF05941.13 ORX69243.1 - 0.011 14.8 1.1 0.016 14.2 1.1 1.1 1 0 0 1 1 1 0 Chordopoxvirus A20R protein DUF3338 PF11819.8 ORX69243.1 - 0.19 11.7 0.1 0.19 11.7 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) CTP_transf_1 PF01148.20 ORX69243.1 - 0.29 10.9 6.2 0.082 12.7 1.3 2.0 2 0 0 2 2 2 0 Cytidylyltransferase family DUF4064 PF13273.6 ORX69243.1 - 0.66 10.3 3.2 0.45 10.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) zinc_ribbon_2 PF13240.6 ORX69243.1 - 1.2 8.9 5.1 2.7 7.8 5.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain eIF-3_zeta PF05091.12 ORX69244.1 - 1.6e-159 532.2 0.0 2e-159 531.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Snapin_Pallidin PF14712.6 ORX69245.1 - 5.3e-07 30.0 6.0 9.6e-05 22.7 0.0 2.6 3 0 0 3 3 3 2 Snapin/Pallidin Met_10 PF02475.16 ORX69246.1 - 5.2e-70 235.3 0.0 7.2e-70 234.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 ORX69246.1 - 0.0034 16.6 0.0 0.006 15.8 0.0 1.4 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase PrmA PF06325.13 ORX69246.1 - 0.045 13.1 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) F-box-like PF12937.7 ORX69247.1 - 3.5e-05 23.6 0.1 0.00012 21.9 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX69247.1 - 0.13 12.2 1.2 0.92 9.5 1.2 2.3 1 1 0 1 1 1 0 F-box domain WD40 PF00400.32 ORX69248.1 - 9.3e-19 67.4 8.4 9.6e-07 29.4 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 ORX69248.1 - 5.2e-17 61.9 0.1 1.4e-16 60.4 0.1 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 ORX69248.1 - 1e-06 29.0 1.2 0.022 15.1 0.2 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Mpp10 PF04006.12 ORX69249.1 - 1.5e-116 390.4 63.0 1.8e-116 390.1 63.0 1.1 1 0 0 1 1 1 1 Mpp10 protein RRP14 PF15459.6 ORX69249.1 - 1.7 9.3 11.5 0.37 11.4 3.4 3.0 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 SLAC1 PF03595.17 ORX69250.1 - 2.6e-77 260.2 43.6 3e-77 260.0 43.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel RRM_1 PF00076.22 ORX69252.1 - 1.5e-15 56.8 0.0 2.4e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX69252.1 - 4.2e-09 36.1 0.0 4.9e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PspB PF06667.12 ORX69252.1 - 0.092 12.8 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Phage shock protein B DAGAT PF03982.13 ORX69253.1 - 3.7e-65 219.8 0.2 4.6e-65 219.5 0.2 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DEAD PF00270.29 ORX69254.1 - 2.9e-37 128.1 0.3 1.1e-36 126.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX69254.1 - 4.6e-29 101.0 0.1 8.6e-29 100.1 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 ORX69254.1 - 0.0046 16.7 0.0 0.009 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 ORX69254.1 - 0.02 14.2 0.0 0.047 13.0 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 ORX69254.1 - 0.068 12.4 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AA_permease PF00324.21 ORX69255.1 - 2.4e-51 174.8 39.8 2.9e-51 174.5 39.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX69255.1 - 1.1e-19 70.6 37.3 1.1e-19 70.6 37.3 1.4 1 1 1 2 2 2 1 Amino acid permease SecD_SecF PF02355.16 ORX69255.1 - 7.5 5.9 14.8 4.7 6.5 0.3 3.4 3 0 0 3 3 3 0 Protein export membrane protein ComFB PF10719.9 ORX69257.1 - 0.073 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Late competence development protein ComFB CLP1_P PF16575.5 ORX69258.1 - 2.8e-29 102.2 0.0 5.7e-28 98.0 0.0 2.3 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop NUDIX PF00293.28 ORX69259.1 - 2.6e-22 79.3 0.3 3e-22 79.1 0.3 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 ORX69259.1 - 0.0036 17.3 0.2 0.1 12.6 0.2 2.2 1 1 0 1 1 1 1 NUDIX domain DUF1917 PF08939.10 ORX69259.1 - 0.068 13.1 0.4 0.09 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) GAF PF01590.26 ORX69259.1 - 0.11 13.1 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 GAF domain Peptidase_M48_N PF16491.5 ORX69260.1 - 8.8e-62 208.2 3.8 8.8e-62 208.2 3.8 2.3 3 1 1 4 4 4 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 ORX69260.1 - 6.6e-50 169.6 0.0 1.3e-49 168.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 ORX69260.1 - 9.3e-06 25.0 0.5 1.5e-05 24.3 0.5 1.3 1 0 0 1 1 1 1 BlaR1 peptidase M56 DUF4538 PF15061.6 ORX69260.1 - 0.033 13.9 0.3 0.085 12.6 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) MRP_L53 PF10780.9 ORX69261.1 - 7.4e-12 45.3 1.1 1e-11 44.8 1.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 TRAPPC9-Trs120 PF08626.11 ORX69263.1 - 1.3e-09 36.1 0.0 1.6e-09 35.8 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Pkinase PF00069.25 ORX69264.1 - 3.4e-37 128.3 0.0 6e-26 91.4 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69264.1 - 3.3e-11 43.0 0.0 7.7e-06 25.4 0.0 2.8 1 1 1 2 2 2 2 Protein tyrosine kinase ABC1 PF03109.16 ORX69264.1 - 0.0062 16.7 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pox_ser-thr_kin PF05445.11 ORX69264.1 - 0.16 10.9 0.2 0.23 10.4 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Nudix_N_2 PF14803.6 ORX69265.1 - 0.0075 16.2 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 Nudix N-terminal Peptidase_M36 PF02128.15 ORX69266.1 - 1.3e-152 508.3 0.5 1.5e-152 508.1 0.5 1.0 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) MatE PF01554.18 ORX69267.1 - 1.2e-47 161.6 25.8 4.3e-25 88.2 10.3 2.4 2 0 0 2 2 2 2 MatE SIS PF01380.22 ORX69268.1 - 2.1e-14 53.5 0.0 3.1e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 SIS domain LAP2alpha PF11560.8 ORX69268.1 - 0.028 13.8 0.4 0.061 12.7 0.1 1.6 2 0 0 2 2 2 0 Lamina-associated polypeptide 2 alpha SIS_2 PF13580.6 ORX69268.1 - 0.12 12.4 0.1 0.64 10.0 0.0 2.0 1 1 1 2 2 2 0 SIS domain Complex1_LYR PF05347.15 ORX69269.1 - 3.4e-10 39.8 0.8 7.2e-10 38.8 0.8 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX69269.1 - 5e-06 27.2 1.0 6.5e-06 26.8 1.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like DUF4729 PF15866.5 ORX69269.1 - 0.057 12.7 0.1 0.086 12.1 0.1 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4729) MBF1 PF08523.10 ORX69270.1 - 1.1e-19 70.6 0.8 1.1e-19 70.6 0.8 1.7 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 ORX69270.1 - 1.2e-06 28.4 0.1 2.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ORX69270.1 - 0.0026 17.8 0.0 0.0045 17.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ORX69270.1 - 0.0032 17.8 0.2 0.01 16.2 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_37 PF13744.6 ORX69270.1 - 0.029 14.3 0.1 0.052 13.5 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.6 ORX69270.1 - 0.045 13.6 0.1 0.071 13.0 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Ima1_N PF09779.9 ORX69271.1 - 1.7e-23 84.0 8.3 1.7e-23 84.0 8.3 1.8 2 0 0 2 2 2 1 Ima1 N-terminal domain zf-RRPl_C4 PF17026.5 ORX69271.1 - 0.065 13.3 2.6 0.51 10.5 0.2 2.3 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DZR PF12773.7 ORX69271.1 - 0.11 12.5 7.4 0.22 11.6 0.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon CpXC PF14353.6 ORX69271.1 - 8.3 6.5 7.4 88 3.2 7.4 2.6 1 1 1 2 2 2 0 CpXC protein p450 PF00067.22 ORX69272.1 - 3.6e-19 68.9 0.0 4.1e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mpv17_PMP22 PF04117.12 ORX69274.1 - 6e-21 74.4 0.3 1.3e-20 73.4 0.3 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family BAR PF03114.18 ORX69275.1 - 1.9e-30 106.3 4.3 2.6e-30 105.8 4.3 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ORX69275.1 - 6.6e-14 51.2 0.1 1.1e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX69275.1 - 1.1e-13 50.8 0.1 1.8e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX69275.1 - 2.9e-08 33.2 0.0 4.9e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Aldedh PF00171.22 ORX69276.1 - 2.8e-150 500.9 0.0 3.1e-150 500.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DALR_2 PF09190.11 ORX69277.1 - 0.051 14.1 1.6 5.9 7.4 0.0 3.1 2 1 0 3 3 3 0 DALR domain BAG PF02179.16 ORX69277.1 - 0.066 13.6 1.7 12 6.4 0.0 2.9 3 0 0 3 3 3 0 BAG domain ANAPC3 PF12895.7 ORX69278.1 - 1.3e-08 35.0 1.5 1.4e-07 31.7 0.0 3.2 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ORX69278.1 - 3.7e-07 30.4 8.6 5.5 8.1 0.0 8.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69278.1 - 9.2e-07 28.4 0.0 1.1 9.2 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69278.1 - 3.2e-06 27.3 13.4 0.063 13.6 0.1 5.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69278.1 - 4.1e-06 26.5 6.9 0.61 10.3 0.0 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX69278.1 - 0.00021 21.1 3.7 1.2 9.1 0.2 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69278.1 - 0.00022 21.7 6.2 2 9.0 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX69278.1 - 0.00026 20.8 3.2 1.8 8.8 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69278.1 - 0.0014 18.6 2.1 0.38 11.1 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 ORX69278.1 - 0.058 14.0 12.5 3.9 8.4 0.4 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PNK3P PF08645.11 ORX69279.1 - 1.1e-50 171.5 0.0 1.5e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ORX69279.1 - 1.4e-14 54.4 0.1 1.7e-07 31.5 0.0 3.6 3 1 1 4 4 4 2 AAA domain AAA_17 PF13207.6 ORX69279.1 - 0.024 15.1 0.0 0.06 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Hydrolase_6 PF13344.6 ORX69279.1 - 0.024 14.8 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase CobU PF02283.16 ORX69279.1 - 0.057 13.0 0.0 12 5.4 0.0 2.3 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase HAD PF12710.7 ORX69279.1 - 0.064 13.6 0.3 0.96 9.8 0.0 2.5 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase 6PF2K PF01591.18 ORX69279.1 - 0.081 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_24 PF13479.6 ORX69279.1 - 0.088 12.5 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX69279.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 ORX69279.1 - 0.12 11.8 0.2 0.28 10.6 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ORX69279.1 - 0.14 11.4 0.0 0.43 9.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin FAD_binding_2 PF00890.24 ORX69280.1 - 5.9e-123 411.0 4.6 7.8e-123 410.6 4.6 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ORX69280.1 - 4.2e-43 146.4 2.1 6.4e-43 145.8 2.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 ORX69280.1 - 0.00051 19.4 1.5 0.007 15.6 0.4 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX69280.1 - 0.00058 19.2 0.5 0.98 8.6 0.1 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 ORX69280.1 - 0.02 14.0 1.9 0.7 8.9 1.9 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A ubiquitin PF00240.23 ORX69281.1 - 6.4e-26 89.9 0.1 7.1e-26 89.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX69281.1 - 1.3e-15 56.9 0.1 1.5e-15 56.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX69281.1 - 0.0002 21.7 0.1 0.00042 20.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ORX69281.1 - 0.002 18.0 0.0 0.0023 17.8 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX69281.1 - 0.0024 17.9 0.6 0.0064 16.5 0.5 1.6 2 0 0 2 2 2 1 Ubiquitin-like domain TPR_1 PF00515.28 ORX69282.1 - 5.9e-13 48.0 5.6 0.0011 18.6 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69282.1 - 6.9e-10 39.4 0.3 1.2e-05 25.9 0.1 6.5 6 1 1 7 7 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69282.1 - 8.6e-10 38.0 2.4 0.0019 18.3 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69282.1 - 2.2e-09 36.7 19.1 0.00026 20.9 0.0 7.2 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX69282.1 - 2e-08 34.1 2.1 0.0029 17.9 0.1 4.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69282.1 - 2.6e-08 33.4 2.2 0.0048 16.5 0.0 4.3 4 1 1 5 5 5 2 TPR repeat TPR_7 PF13176.6 ORX69282.1 - 5.2e-06 26.1 7.9 2.6 8.3 0.0 7.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69282.1 - 0.00044 20.7 9.4 0.0089 16.5 0.0 5.8 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69282.1 - 0.0032 18.1 35.4 0.4 11.6 0.0 10.2 9 2 2 11 11 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX69282.1 - 0.0072 16.9 8.0 0.025 15.2 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX69282.1 - 0.039 13.8 5.2 0.64 10.0 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX69282.1 - 0.049 13.7 0.9 0.19 11.8 0.0 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat RNA_pol_inhib PF16857.5 ORX69282.1 - 0.064 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase inhibitor TPR_12 PF13424.6 ORX69282.1 - 0.098 13.0 21.9 0.56 10.5 0.0 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat HMG_CoA_synt_C PF08540.10 ORX69283.1 - 9.3e-98 327.3 0.6 1.2e-97 326.9 0.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 ORX69283.1 - 1.2e-89 298.8 0.3 1.8e-89 298.2 0.3 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal RNaseH_like PF04308.12 ORX69283.1 - 0.12 12.3 0.1 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease H-like PI-PLC-C1 PF16670.5 ORX69284.1 - 0.00032 19.9 0.0 0.32 10.0 0.0 2.6 2 1 1 3 3 3 2 Phosphoinositide phospholipase C, Ca2+-dependent DUF957 PF06117.11 ORX69284.1 - 0.028 14.0 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) DUF4160 PF13711.6 ORX69284.1 - 0.059 13.7 0.0 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) PI-PLC-X PF00388.19 ORX69284.1 - 0.092 12.3 0.0 0.18 11.4 0.0 1.6 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DEAD PF00270.29 ORX69286.1 - 7.9e-47 159.3 0.0 1.2e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX69286.1 - 2.8e-29 101.7 0.0 9.2e-29 100.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX69286.1 - 1.1e-05 25.5 0.0 4.1e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit 2OG-FeII_Oxy_2 PF13532.6 ORX69287.1 - 9.3e-16 58.6 0.0 2e-15 57.5 0.0 1.5 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Q_salvage PF10343.9 ORX69288.1 - 1.1e-110 369.6 0.1 1.4e-110 369.4 0.1 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 ORX69288.1 - 0.0011 17.8 0.0 0.045 12.5 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1688) Bcl-2 PF00452.19 ORX69288.1 - 0.031 14.9 0.2 0.088 13.5 0.1 1.8 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family p450 PF00067.22 ORX69289.1 - 1e-60 205.8 0.1 1e-48 166.3 0.1 2.9 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 ORX69290.1 - 0.006 15.4 0.0 0.0072 15.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Vps5 PF09325.10 ORX69291.1 - 9.2e-08 31.9 3.8 4.3e-07 29.7 0.8 2.3 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 ORX69291.1 - 5.6e-06 26.3 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 PX domain Uds1 PF15456.6 ORX69291.1 - 0.26 11.4 5.1 0.13 12.4 0.9 2.5 2 1 0 2 2 2 0 Up-regulated During Septation Ribosomal_L37 PF08561.10 ORX69292.1 - 9.5e-21 74.5 4.3 2.9e-19 69.8 0.8 2.0 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 CD99L2 PF12301.8 ORX69293.1 - 0.0045 17.3 0.4 0.0062 16.9 0.4 1.3 1 0 0 1 1 1 1 CD99 antigen like protein 2 Septin PF00735.18 ORX69294.1 - 1.6e-67 227.8 0.1 1.4e-44 152.5 0.0 2.0 1 1 1 2 2 2 2 Septin Spt5_N PF11942.8 ORX69295.1 - 1.6e-10 41.8 5.3 1.6e-10 41.8 5.3 2.8 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 ORX69295.1 - 1.8e-09 37.2 33.9 0.026 14.5 0.0 7.5 8 0 0 8 8 8 4 KOW motif DUF3912 PF13051.6 ORX69295.1 - 0.012 15.8 2.0 0.11 12.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) p450 PF00067.22 ORX69296.1 - 1.2e-41 143.0 0.0 9.2e-25 87.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Vps39_2 PF10367.9 ORX69296.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Chorismate_synt PF01264.21 ORX69296.1 - 0.25 10.0 0.0 0.35 9.5 0.0 1.1 1 0 0 1 1 1 0 Chorismate synthase p450 PF00067.22 ORX69297.1 - 7.8e-64 216.1 0.0 2.8e-61 207.7 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Q_salvage PF10343.9 ORX69298.1 - 5.7e-110 367.3 0.1 6.8e-110 367.1 0.1 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 ORX69298.1 - 0.00057 18.7 0.0 0.029 13.1 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1688) Bcl-2 PF00452.19 ORX69298.1 - 0.033 14.9 0.3 0.092 13.4 0.1 1.8 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family 2OG-FeII_Oxy_2 PF13532.6 ORX69299.1 - 4.3e-16 59.7 0.0 7.6e-16 58.9 0.0 1.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DEAD PF00270.29 ORX69300.1 - 8.1e-47 159.2 0.0 1.2e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX69300.1 - 2.8e-29 101.7 0.0 9.2e-29 100.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX69300.1 - 1.6e-05 25.0 0.0 4.1e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PI-PLC-C1 PF16670.5 ORX69302.1 - 0.00028 20.1 0.0 0.092 11.8 0.0 2.4 2 1 1 3 3 3 2 Phosphoinositide phospholipase C, Ca2+-dependent PI-PLC-X PF00388.19 ORX69302.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain HMG_CoA_synt_N PF01154.17 ORX69303.1 - 1.1e-89 298.9 0.3 1.7e-89 298.3 0.3 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 ORX69303.1 - 1.2e-85 287.6 2.6 1.9e-56 191.7 0.2 2.1 1 1 1 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal RNaseH_like PF04308.12 ORX69303.1 - 0.08 12.9 0.1 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease H-like TPR_1 PF00515.28 ORX69304.1 - 0.00088 19.0 5.2 0.6 10.0 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69304.1 - 0.0022 18.0 0.4 14 6.2 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69304.1 - 0.0051 16.5 1.0 2.4 7.9 0.0 4.4 5 0 0 5 5 5 1 TPR repeat TPR_17 PF13431.6 ORX69304.1 - 0.12 12.8 3.6 8.7 7.0 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TniQ PF06527.11 ORX69304.1 - 0.13 13.0 1.6 0.4 11.4 0.2 2.6 2 0 0 2 2 2 0 TniQ TPR_2 PF07719.17 ORX69304.1 - 0.53 10.5 11.9 0.62 10.3 0.0 5.7 8 0 0 8 8 8 0 Tetratricopeptide repeat ubiquitin PF00240.23 ORX69305.1 - 6.4e-26 89.9 0.1 7.1e-26 89.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX69305.1 - 1.3e-15 56.9 0.1 1.5e-15 56.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX69305.1 - 0.0002 21.7 0.1 0.00042 20.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ORX69305.1 - 0.002 18.0 0.0 0.0023 17.8 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX69305.1 - 0.0024 17.9 0.6 0.0064 16.5 0.5 1.6 2 0 0 2 2 2 1 Ubiquitin-like domain FAD_binding_2 PF00890.24 ORX69306.1 - 4.7e-98 329.0 13.4 7.3e-97 325.1 13.4 2.1 1 1 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ORX69306.1 - 1e-34 119.3 0.2 1.6e-34 118.6 0.2 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.17 ORX69306.1 - 0.00017 20.9 0.7 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 ORX69306.1 - 0.014 14.6 3.7 0.057 12.6 1.9 2.6 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX69306.1 - 0.6 9.1 3.9 27 3.7 4.2 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A PNK3P PF08645.11 ORX69307.1 - 1.7e-42 144.9 0.0 2.4e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ORX69307.1 - 1.4e-12 48.0 0.0 1.3e-08 35.2 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ORX69307.1 - 0.021 15.2 0.0 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Hydrolase_6 PF13344.6 ORX69307.1 - 0.031 14.4 0.0 0.081 13.0 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase CobU PF02283.16 ORX69307.1 - 0.037 13.6 0.0 8.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase 6PF2K PF01591.18 ORX69307.1 - 0.073 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 ORX69307.1 - 0.089 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 ORX69307.1 - 0.11 11.9 0.3 0.22 11.0 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 HAD PF12710.7 ORX69307.1 - 0.11 12.9 0.0 0.28 11.5 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.12 ORX69307.1 - 0.12 11.6 0.0 0.37 10.0 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin TPR_1 PF00515.28 ORX69308.1 - 6.3e-08 32.1 0.0 0.066 13.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69308.1 - 2.6e-07 30.2 0.7 0.36 11.0 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69308.1 - 3.4e-07 30.4 3.9 0.055 13.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX69308.1 - 2.4e-06 27.2 0.4 0.75 9.8 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX69308.1 - 1.7e-05 24.5 0.6 0.13 12.4 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69308.1 - 5e-05 23.8 1.6 3.2 8.8 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69308.1 - 0.0014 18.7 2.1 0.042 14.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69308.1 - 0.014 15.9 1.0 58 4.3 0.3 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX69308.1 - 0.03 14.7 0.4 52 4.5 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat BAG PF02179.16 ORX69309.1 - 0.032 14.7 0.6 8.2 6.9 0.1 2.5 2 0 0 2 2 2 0 BAG domain DALR_2 PF09190.11 ORX69309.1 - 0.04 14.4 1.0 4.1 8.0 0.0 2.8 2 1 1 3 3 3 0 DALR domain Spore_GerAC PF05504.11 ORX69309.1 - 0.082 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Nup54 PF13874.6 ORX69309.1 - 0.1 12.7 2.2 0.13 12.4 2.2 1.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Aldedh PF00171.22 ORX69310.1 - 1.3e-150 502.0 0.0 1.4e-150 501.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BAR PF03114.18 ORX69311.1 - 4.5e-30 105.1 4.2 6e-30 104.6 4.2 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ORX69311.1 - 6.6e-14 51.2 0.1 1.1e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX69311.1 - 1.1e-13 50.8 0.1 1.8e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX69311.1 - 2.9e-08 33.3 0.0 4.9e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Mpv17_PMP22 PF04117.12 ORX69312.1 - 1e-20 73.7 0.3 1.6e-20 73.0 0.3 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family MFS_1 PF07690.16 ORX69360.1 - 5.4e-15 55.2 23.5 1e-14 54.3 23.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ORX69360.1 - 1.1e-14 54.4 6.7 1.1e-14 54.4 6.7 1.9 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 UcrQ PF02939.16 ORX69360.1 - 0.078 12.9 0.1 0.25 11.3 0.1 1.9 1 0 0 1 1 1 0 UcrQ family GFO_IDH_MocA PF01408.22 ORX69361.1 - 7e-24 85.0 0.0 1.2e-23 84.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ORX69361.1 - 4e-06 26.8 0.0 8.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ORX69361.1 - 0.12 13.0 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PE_PPE_C PF12484.8 ORX69362.1 - 0.86 10.6 3.8 17 6.4 0.1 2.4 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal Ald_Xan_dh_C2 PF02738.18 ORX69363.1 - 8.2e-172 572.5 0.8 1.1e-171 572.0 0.8 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.22 ORX69363.1 - 4e-28 98.0 0.3 1.9e-27 95.8 0.0 2.2 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 ORX69363.1 - 1.5e-27 95.4 0.1 5.9e-27 93.5 0.1 2.2 1 0 0 1 1 1 1 [2Fe-2S] binding domain FAD_binding_5 PF00941.21 ORX69363.1 - 6.4e-27 94.4 0.2 1.2e-26 93.5 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 ORX69363.1 - 2.1e-12 47.1 0.1 8.4e-12 45.2 0.1 2.1 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 ORX69363.1 - 1.5e-05 24.9 0.2 6e-05 22.9 0.1 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHHA1 PF02272.19 ORX69363.1 - 0.048 14.1 0.0 1 9.8 0.0 2.6 2 1 0 2 2 2 0 DHHA1 domain SMYLE_N PF18615.1 ORX69363.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain F-box-like PF12937.7 ORX69366.1 - 0.00061 19.6 0.3 0.027 14.4 0.0 2.8 2 0 0 2 2 2 2 F-box-like MFS_1 PF07690.16 ORX69367.1 - 1.5e-16 60.3 23.2 2.5e-16 59.6 23.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ORX69367.1 - 9.2e-15 54.7 8.9 9.2e-15 54.7 8.9 2.0 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 UQ_con PF00179.26 ORX69370.1 - 4.9e-51 172.1 0.0 5.6e-51 171.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX69370.1 - 0.00016 21.4 0.0 0.0002 21.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ORX69370.1 - 0.076 13.3 0.0 0.1 12.9 0.0 1.3 1 1 0 1 1 1 0 RWD domain Nup96 PF12110.8 ORX69371.1 - 4.8e-61 206.4 0.2 6.9e-61 205.9 0.2 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 ORX69371.1 - 5.7e-50 169.3 0.0 9.6e-50 168.6 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 ORX69371.1 - 1e-18 67.9 82.1 1.2e-11 45.3 38.0 11.8 3 3 7 10 10 10 3 Nucleoporin FG repeat region TEX13 PF15186.6 ORX69371.1 - 0.066 12.9 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DUF948 PF06103.11 ORX69371.1 - 0.099 12.9 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) RmuC PF02646.16 ORX69371.1 - 0.19 10.8 0.1 0.33 10.1 0.1 1.2 1 0 0 1 1 1 0 RmuC family PBP1_TM PF14812.6 ORX69371.1 - 7.8 6.9 9.8 17 5.9 7.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nop14 PF04147.12 ORX69372.1 - 7.1e-231 769.0 18.6 8.5e-231 768.7 18.6 1.1 1 0 0 1 1 1 1 Nop14-like family RNA_pol_Rpb1_1 PF04997.12 ORX69374.1 - 1.5e-86 290.5 0.0 2.3e-86 289.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ORX69374.1 - 1.9e-80 270.2 0.0 2.7e-80 269.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ORX69374.1 - 6.9e-74 247.6 0.1 1.8e-73 246.3 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ORX69374.1 - 2e-37 128.5 0.0 4.7e-37 127.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ORX69374.1 - 1.2e-28 99.2 0.0 2.7e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Ima1_N PF09779.9 ORX69374.1 - 0.21 12.4 1.1 0.44 11.4 0.2 2.0 2 0 0 2 2 2 0 Ima1 N-terminal domain UNC-93 PF05978.16 ORX69375.1 - 3.2e-15 56.2 6.8 8.7e-15 54.8 6.8 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ORX69375.1 - 2.1e-14 53.2 24.4 2.1e-14 53.2 24.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily UcrQ PF02939.16 ORX69375.1 - 0.049 13.6 0.5 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 UcrQ family Voltage_CLC PF00654.20 ORX69376.1 - 1.3e-86 291.1 28.6 1.3e-86 291.1 28.6 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ORX69376.1 - 3e-10 40.4 1.0 1.2e-06 28.8 0.1 2.6 2 0 0 2 2 2 2 CBS domain RTA1 PF04479.13 ORX69377.1 - 1.8e-42 145.3 15.7 1.8e-42 145.3 15.7 1.4 2 0 0 2 2 2 1 RTA1 like protein Ribonuclease_T2 PF00445.18 ORX69378.1 - 2.4e-39 135.4 2.3 3.5e-39 134.9 2.3 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family SLAC1 PF03595.17 ORX69379.1 - 1.7e-21 76.8 32.6 2.1e-21 76.5 32.6 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF5383 PF17355.2 ORX69379.1 - 0.24 11.8 0.4 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5383) AA_permease_2 PF13520.6 ORX69381.1 - 3.5e-75 253.4 30.2 4.3e-75 253.1 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX69381.1 - 2.1e-25 89.3 28.7 2.6e-25 89.0 28.7 1.1 1 0 0 1 1 1 1 Amino acid permease L6_membrane PF05805.12 ORX69381.1 - 1.6 8.3 19.8 0.028 14.0 1.2 3.7 3 2 1 4 4 4 0 L6 membrane protein Tetraspanin PF00335.20 ORX69381.1 - 8.4 6.0 9.2 2 8.1 4.3 2.4 2 0 0 2 2 2 0 Tetraspanin family CHAP PF05257.16 ORX69382.1 - 9.2e-08 32.6 3.2 9.2e-08 32.6 3.2 1.7 2 0 0 2 2 2 1 CHAP domain SH3_3 PF08239.11 ORX69382.1 - 0.0021 18.3 0.0 0.005 17.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain MPC PF03650.13 ORX69383.1 - 2.1e-31 108.3 0.1 2.4e-31 108.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DUF3020 PF11223.8 ORX69384.1 - 3.2e-20 72.4 6.6 3.2e-20 72.4 6.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3020) HBM PF16591.5 ORX69384.1 - 0.026 13.9 10.5 0.037 13.4 10.5 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain V_ATPase_I PF01496.19 ORX69384.1 - 5.4 4.8 10.6 6.4 4.6 10.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UCH PF00443.29 ORX69385.1 - 3.4e-43 148.0 0.0 4.4e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX69385.1 - 4.2e-17 62.7 0.0 1.7e-14 54.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ORX69385.1 - 8.1e-16 58.1 6.5 3e-15 56.3 6.5 2.1 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein MIP PF00230.20 ORX69386.1 - 9.7e-39 133.4 13.2 1.1e-38 133.2 13.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein CPP1-like PF11833.8 ORX69386.1 - 0.055 13.1 1.8 4.5 6.9 0.1 2.2 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Phage_lysozyme PF00959.19 ORX69387.1 - 8.4e-12 45.5 0.0 1.6e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69387.1 - 4.6e-05 23.6 0.3 0.00011 22.3 0.3 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain SieB PF14163.6 ORX69388.1 - 0.16 11.5 0.1 0.16 11.5 0.1 2.4 2 1 0 2 2 2 0 Super-infection exclusion protein B Voltage_CLC PF00654.20 ORX69389.1 - 1.6e-86 290.7 21.9 2.8e-85 286.7 18.7 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 ORX69389.1 - 7.5e-06 26.3 0.1 0.0056 17.1 0.0 3.4 3 0 0 3 3 3 1 CBS domain Phage_holin_3_3 PF16083.5 ORX69389.1 - 2.1 8.5 13.7 0.13 12.4 0.2 4.4 4 1 0 4 4 4 0 LydA holin phage, holin superfamily III CHAP PF05257.16 ORX69390.1 - 6.9e-14 52.2 5.1 1.2e-13 51.4 5.1 1.4 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69390.1 - 0.00087 19.5 0.4 0.0022 18.2 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain Phage_term_sma PF07141.11 ORX69390.1 - 0.12 12.2 0.1 0.23 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative bacteriophage terminase small subunit CHAP PF05257.16 ORX69391.1 - 2e-14 53.9 5.2 3.8e-14 53.0 5.2 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69391.1 - 1.3e-05 25.4 0.5 4e-05 23.8 0.1 2.0 2 1 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69392.1 - 5.9e-16 58.8 4.1 1.1e-15 57.9 4.1 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69392.1 - 0.0031 17.8 1.4 0.0075 16.5 0.1 2.3 2 1 0 2 2 2 1 Bacterial SH3 domain Phage_lysozyme PF00959.19 ORX69393.1 - 7.6e-15 55.3 0.0 1.3e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69393.1 - 3.8e-07 30.3 0.3 1.2e-06 28.6 0.3 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain Proteasom_Rpn13 PF04683.13 ORX69395.1 - 2.9e-28 98.2 0.5 4.5e-28 97.6 0.5 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 ORX69395.1 - 3.8e-28 97.9 0.5 6.1e-28 97.2 0.5 1.3 1 0 0 1 1 1 1 UCH-binding domain TFIIE-A_C PF11521.8 ORX69395.1 - 3.5 8.0 6.4 2 8.8 0.6 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha PALP PF00291.25 ORX69396.1 - 1.4e-67 228.2 0.5 1.8e-67 227.8 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme APH PF01636.23 ORX69397.1 - 9e-10 38.9 0.0 3.3e-09 37.0 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family CYYR1 PF10873.8 ORX69398.1 - 0.63 10.5 2.1 0.79 10.2 2.1 1.3 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 CD34_antigen PF06365.12 ORX69399.1 - 0.22 11.1 0.6 0.63 9.6 0.0 1.9 2 0 0 2 2 2 0 CD34/Podocalyxin family COG5 PF10392.9 ORX69402.1 - 4.6e-18 65.7 0.3 1.3e-17 64.2 0.3 1.9 1 0 0 1 1 1 1 Golgi transport complex subunit 5 FliH PF02108.16 ORX69402.1 - 0.0028 17.7 0.8 0.0093 16.0 0.8 1.9 1 0 0 1 1 1 1 Flagellar assembly protein FliH Vps54_N PF10475.9 ORX69402.1 - 0.076 12.3 0.1 0.16 11.2 0.1 1.5 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Vps51 PF08700.11 ORX69402.1 - 0.087 12.9 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 Vps51/Vps67 7tm_3 PF00003.22 ORX69403.1 - 3.7e-05 23.6 23.8 5.3e-05 23.1 23.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX69404.1 - 1.7e-07 31.2 28.5 2.4e-07 30.7 28.5 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR CreD PF06123.12 ORX69404.1 - 0.48 9.1 2.6 3.2 6.5 2.6 2.0 2 0 0 2 2 2 0 Inner membrane protein CreD Fig1 PF12351.8 ORX69405.1 - 0.12 12.3 6.9 0.16 11.9 1.1 2.4 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 DUF2569 PF10754.9 ORX69406.1 - 0.49 10.8 20.3 4.9 7.6 0.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) Pyridoxal_deC PF00282.19 ORX69407.1 - 1.5e-67 228.0 0.0 1.3e-66 224.9 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ORX69407.1 - 0.00074 18.6 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ORX69407.1 - 0.012 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase FLILHELTA PF10306.9 ORX69408.1 - 0.0058 17.0 0.1 0.013 15.9 0.1 1.6 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF4728 PF15860.5 ORX69408.1 - 0.97 10.2 5.5 0.32 11.7 0.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) GWT1 PF06423.12 ORX69409.1 - 1.7 8.8 9.8 0.9 9.7 0.1 2.5 2 1 0 2 2 2 0 GWT1 Elf1 PF05129.13 ORX69410.1 - 2.9e-29 101.0 3.4 3.1e-29 100.8 3.4 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.10 ORX69410.1 - 0.014 15.5 0.5 0.024 14.8 0.5 1.4 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 ORX69410.1 - 0.047 14.0 2.9 1.1 9.7 0.3 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Ribosomal_L37ae PF01780.19 ORX69410.1 - 0.16 12.1 1.8 0.3 11.2 1.8 1.3 1 1 0 1 1 1 0 Ribosomal L37ae protein family DHquinase_II PF01220.19 ORX69410.1 - 0.17 11.6 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Dehydroquinase class II 7tm_3 PF00003.22 ORX69411.1 - 9.3e-08 32.1 26.4 1.4e-07 31.5 26.4 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR COX2-transmemb PF09125.10 ORX69412.1 - 0.18 11.7 3.3 0.39 10.6 0.0 3.1 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane Ytp1 PF10355.9 ORX69413.1 - 1.6e-29 103.0 23.8 2e-27 96.2 23.8 3.0 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ORX69413.1 - 1.1e-09 38.0 0.6 1.1e-09 38.0 0.6 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) GPR_Gpa2_C PF11970.8 ORX69414.1 - 0.041 13.9 1.2 0.041 13.9 1.2 3.2 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF2975 PF11188.8 ORX69414.1 - 0.53 10.2 12.0 0.059 13.3 4.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) OAD_gamma PF04277.13 ORX69414.1 - 0.55 10.8 0.1 0.55 10.8 0.1 2.8 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain SieB PF14163.6 ORX69414.1 - 0.76 9.3 0.0 0.76 9.3 0.0 2.8 3 0 0 3 3 3 0 Super-infection exclusion protein B RhodobacterPufX PF11511.8 ORX69414.1 - 1.4 8.6 6.8 1.8 8.2 0.0 2.9 3 0 0 3 3 3 0 Intrinsic membrane protein PufX bZIP_2 PF07716.15 ORX69415.1 - 2e-07 31.0 17.0 3.5e-07 30.2 17.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX69415.1 - 5.6e-07 29.6 14.5 5.6e-07 29.6 14.5 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX69415.1 - 0.00072 20.0 8.3 0.00072 20.0 8.3 1.9 2 0 0 2 2 2 1 bZIP Maf transcription factor DUF4679 PF15728.5 ORX69415.1 - 0.0074 15.4 4.6 0.009 15.1 4.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4679) Cortex-I_coil PF09304.10 ORX69415.1 - 0.0094 16.2 10.6 0.028 14.6 3.9 2.2 2 0 0 2 2 2 2 Cortexillin I, coiled coil DLP_helical PF18709.1 ORX69415.1 - 0.07 12.3 3.8 0.09 12.0 3.8 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain Phage_Mu_Gam PF07352.12 ORX69415.1 - 0.14 12.1 3.6 3.4 7.6 0.2 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DUF1515 PF07439.11 ORX69415.1 - 1.9 8.5 6.8 0.74 9.9 3.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) CDC45 PF02724.14 ORX69415.1 - 2.2 6.5 10.9 2.7 6.2 10.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.11 ORX69415.1 - 5.6 5.7 9.6 7.1 5.4 9.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Phage_lysozyme PF00959.19 ORX69416.1 - 7.6e-15 55.3 0.0 1.3e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69416.1 - 3.8e-07 30.3 0.3 1.2e-06 28.6 0.3 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain Forkhead PF00250.18 ORX69418.1 - 3.6e-30 104.1 0.0 4.2e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Forkhead domain Drf_FH3 PF06367.16 ORX69419.1 - 4.7e-06 26.3 0.2 1.1e-05 25.1 0.2 1.6 1 1 0 1 1 1 1 Diaphanous FH3 Domain Mito_carr PF00153.27 ORX69420.1 - 5.1e-65 215.4 3.7 2.1e-21 75.6 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ion_trans PF00520.31 ORX69421.1 - 0.0048 16.2 0.5 0.005 16.1 0.5 1.0 1 0 0 1 1 1 1 Ion transport protein TMCO5 PF14992.6 ORX69421.1 - 0.2 11.2 0.3 0.23 11.0 0.3 1.0 1 0 0 1 1 1 0 TMCO5 family Hydrolase_4 PF12146.8 ORX69422.1 - 9.2e-13 48.0 0.0 4e-08 32.8 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ORX69422.1 - 2.9e-07 30.2 0.0 2.8e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ORX69422.1 - 4.5e-05 24.2 0.0 6.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX69422.1 - 8.9e-05 22.3 0.0 0.0024 17.6 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 ORX69422.1 - 0.00081 19.0 0.0 0.0069 16.0 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 ORX69422.1 - 0.003 16.3 0.0 0.04 12.6 0.0 2.3 1 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 ORX69422.1 - 0.0046 16.6 0.0 0.0097 15.6 0.0 1.5 1 1 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 ORX69422.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 ORX69422.1 - 0.088 12.7 0.0 1.3 8.9 0.0 2.3 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal TTL PF03133.15 ORX69423.1 - 3.9e-51 173.9 0.0 5e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ORX69423.1 - 0.00052 19.3 0.0 0.037 13.3 0.0 2.1 2 0 0 2 2 2 2 YheC/D like ATP-grasp GSH_synth_ATP PF03917.17 ORX69423.1 - 0.083 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain ATPgrasp_ST PF14397.6 ORX69423.1 - 0.094 12.0 0.0 1.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ABC2_membrane PF01061.24 ORX69424.1 - 1.7e-36 125.6 25.7 1.7e-36 125.6 25.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ORX69424.1 - 4.3e-24 85.6 0.0 1e-23 84.3 0.0 1.7 1 1 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ORX69424.1 - 6e-09 35.5 19.2 1e-08 34.7 19.2 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ORX69424.1 - 1.8e-05 24.7 2.0 0.098 12.4 0.0 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX69424.1 - 0.00025 21.0 0.1 0.00053 19.9 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ORX69424.1 - 0.00029 20.5 0.8 0.00065 19.4 0.8 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX69424.1 - 0.0013 18.8 0.0 0.0033 17.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ORX69424.1 - 0.004 17.7 0.1 0.007 16.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX69424.1 - 0.0056 17.1 0.1 0.0093 16.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ORX69424.1 - 0.0081 16.4 1.3 0.016 15.5 1.3 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ORX69424.1 - 0.014 14.9 0.1 0.033 13.6 0.1 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 ORX69424.1 - 0.04 14.0 0.5 0.086 12.9 0.2 1.7 2 0 0 2 2 1 0 Dynamin family AAA_25 PF13481.6 ORX69424.1 - 0.052 13.1 0.2 0.14 11.7 0.2 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX69424.1 - 0.053 13.4 0.1 0.094 12.6 0.1 1.4 1 0 0 1 1 1 0 NACHT domain SbcCD_C PF13558.6 ORX69424.1 - 0.054 13.7 0.2 0.82 9.9 0.1 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF1440 PF07274.12 ORX69424.1 - 0.063 13.6 0.2 0.063 13.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) AAA_33 PF13671.6 ORX69424.1 - 0.07 13.3 0.1 0.22 11.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX69424.1 - 0.076 13.3 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX69424.1 - 0.12 13.0 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX69424.1 - 0.17 11.6 0.2 0.37 10.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX69424.1 - 0.19 11.3 0.3 0.32 10.6 0.3 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.18 ORX69424.1 - 0.2 11.4 0.2 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Cation_efflux PF01545.21 ORX69425.1 - 1.3e-25 90.3 12.5 1.7e-25 90.0 12.5 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ORX69425.1 - 5e-08 32.9 0.2 1.3e-07 31.7 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF2678 PF10856.8 ORX69425.1 - 0.045 13.7 0.9 8.2 6.4 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) MIF4G_like_2 PF09090.11 ORX69425.1 - 0.061 12.8 0.6 0.095 12.2 0.6 1.2 1 0 0 1 1 1 0 MIF4G like Rop-like PF05082.13 ORX69425.1 - 0.12 12.2 0.3 0.27 11.1 0.0 1.7 2 0 0 2 2 2 0 Rop-like Med14 PF08638.11 ORX69426.1 - 1.6e-61 207.0 0.0 1.6e-60 203.8 0.0 2.7 2 0 0 2 2 2 1 Mediator complex subunit MED14 Ofd1_CTDD PF10637.9 ORX69427.1 - 5.5e-35 120.9 0.4 1.4e-31 109.8 0.1 3.3 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ORX69427.1 - 3.1e-27 95.1 0.3 8.4e-23 80.9 0.1 2.2 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ORX69427.1 - 4.8e-19 69.0 0.3 7.4e-17 62.0 0.1 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily ECH_1 PF00378.20 ORX69428.1 - 3.4e-56 190.4 0.0 8.4e-56 189.1 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX69428.1 - 2.3e-32 112.8 0.0 8.6e-31 107.7 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase CCD48 PF15799.5 ORX69428.1 - 0.076 11.3 0.0 0.1 10.9 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Phage_lysozyme PF00959.19 ORX69429.1 - 8.7e-16 58.3 0.0 1.5e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69429.1 - 4e-07 30.2 0.3 1.2e-06 28.6 0.3 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain CHAP PF05257.16 ORX69431.1 - 4.7e-16 59.1 4.3 9e-16 58.2 4.3 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69431.1 - 0.0042 17.4 1.7 0.0073 16.6 0.1 2.3 2 1 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69432.1 - 2e-14 53.9 5.2 3.8e-14 53.0 5.2 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69432.1 - 1.3e-05 25.4 0.5 4e-05 23.8 0.1 2.0 2 1 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69433.1 - 2.8e-14 53.4 4.6 6.6e-14 52.2 4.6 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69433.1 - 0.00012 22.3 1.2 0.00019 21.6 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69434.1 - 1e-13 51.6 4.1 1.9e-13 50.8 4.1 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69434.1 - 2e-05 24.7 0.7 5.3e-05 23.4 0.1 2.0 2 1 0 2 2 2 1 Bacterial SH3 domain Amidohydro_1 PF01979.20 ORX69435.1 - 1.4e-66 225.1 1.9 8.4e-66 222.6 1.8 2.0 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 ORX69435.1 - 9.2e-54 180.9 1.2 1.9e-53 179.9 1.2 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 ORX69435.1 - 3.7e-39 132.7 0.2 1.2e-38 131.1 0.1 1.9 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 ORX69435.1 - 5e-37 126.2 0.1 1.1e-36 125.1 0.1 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 ORX69435.1 - 4.3e-09 36.4 0.2 7.2e-08 32.3 0.0 2.5 2 0 0 2 2 2 1 Amidohydrolase family ECR1_N PF14382.6 ORX69435.1 - 0.06 13.2 0.1 0.17 11.7 0.1 1.8 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region Methyltransf_16 PF10294.9 ORX69436.1 - 1.5e-25 89.9 0.1 5.4e-25 88.1 0.1 1.9 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 ORX69436.1 - 0.08 13.7 0.1 0.35 11.6 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain GPR_Gpa2_C PF11970.8 ORX69437.1 - 0.001 19.1 0.3 0.0016 18.5 0.3 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Phage_lysozyme PF00959.19 ORX69438.1 - 1.7e-13 50.9 0.0 2.6e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69438.1 - 4.2e-06 27.0 0.3 1.5e-05 25.2 0.3 2.0 1 0 0 1 1 1 1 Bacterial SH3 domain CHAP PF05257.16 ORX69439.1 - 9.8e-15 54.9 3.2 1.9e-14 54.0 3.2 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69439.1 - 0.00027 21.2 0.1 0.00027 21.2 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain Carb_kinase PF01256.17 ORX69440.1 - 7.3e-54 182.8 0.0 9.3e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 ORX69440.1 - 2.5e-06 27.1 0.0 2.1e-05 24.1 0.0 2.3 2 1 0 2 2 2 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 ORX69440.1 - 0.00013 21.4 0.0 0.00033 20.1 0.0 1.6 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase Na_H_Exchanger PF00999.21 ORX69442.1 - 2.2e-57 194.6 15.9 2.5e-57 194.4 15.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 ORX69442.1 - 0.014 15.4 0.1 0.014 15.4 0.1 2.7 3 0 0 3 3 3 0 YrhC-like protein Mito_carr PF00153.27 ORX69443.1 - 6.1e-70 231.2 5.9 1.1e-24 86.2 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ORX69443.1 - 0.066 13.6 0.3 0.066 13.6 0.3 2.7 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family 3HCDH_N PF02737.18 ORX69444.1 - 2.2e-59 200.4 3.1 2.8e-59 200.0 3.1 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ORX69444.1 - 7.1e-31 106.7 2.6 1.9e-30 105.3 0.1 2.6 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ORX69444.1 - 2.1e-05 24.7 4.8 9.1e-05 22.7 2.4 2.3 2 1 0 2 2 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 ORX69444.1 - 0.0003 20.1 0.1 0.00049 19.4 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ORX69444.1 - 0.00047 19.5 1.4 0.00093 18.6 1.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX69444.1 - 0.0011 18.6 0.6 0.0028 17.2 0.6 1.7 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ORX69444.1 - 0.0048 16.9 2.2 0.0059 16.6 0.5 2.0 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 ORX69444.1 - 0.0095 16.2 0.2 0.025 14.9 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain Pyr_redox PF00070.27 ORX69444.1 - 0.011 16.3 0.3 0.024 15.2 0.3 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 ORX69444.1 - 0.012 16.2 2.8 0.091 13.4 2.8 2.3 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_RFF PF18321.1 ORX69444.1 - 0.043 14.3 0.5 0.13 12.7 0.0 2.1 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain NAD_binding_7 PF13241.6 ORX69444.1 - 0.046 14.2 0.3 0.085 13.3 0.3 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ORX69444.1 - 0.06 13.6 1.5 0.22 11.8 1.5 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GCHY-1 PF02649.14 ORX69444.1 - 0.076 12.5 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 DXP_synthase_N PF13292.6 ORX69444.1 - 0.084 12.1 0.3 0.13 11.5 0.3 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase LigB PF02900.18 ORX69445.1 - 3.7e-35 121.3 0.0 4.3e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase ACT_7 PF13840.6 ORX69445.1 - 0.16 11.7 0.0 1.1 9.1 0.0 2.3 2 1 1 3 3 3 0 ACT domain GATA PF00320.27 ORX69447.1 - 3.3e-10 39.4 6.5 6.9e-10 38.4 6.5 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF3335 PF11814.8 ORX69447.1 - 0.071 12.6 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Peptidase_C39 like family Chlorovi_GP_rpt PF06598.11 ORX69447.1 - 0.12 12.5 0.9 0.31 11.1 0.9 1.7 1 0 0 1 1 1 0 Chlorovirus glycoprotein repeat 7tm_3 PF00003.22 ORX69448.1 - 1.7e-05 24.7 29.1 0.013 15.2 3.0 2.2 1 1 1 2 2 2 2 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX69449.1 - 2.8e-05 24.0 30.8 3.9e-05 23.5 30.8 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR CD34_antigen PF06365.12 ORX69449.1 - 0.064 12.8 0.0 0.064 12.8 0.0 2.1 3 0 0 3 3 3 0 CD34/Podocalyxin family DUF2556 PF10831.8 ORX69449.1 - 1.4 8.9 5.1 27 4.8 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2556) GATA PF00320.27 ORX69450.1 - 3.4e-10 39.4 6.5 7.2e-10 38.3 6.5 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF3335 PF11814.8 ORX69450.1 - 0.062 12.8 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase_C39 like family Chlorovi_GP_rpt PF06598.11 ORX69450.1 - 0.12 12.4 0.9 0.32 11.1 0.9 1.7 1 0 0 1 1 1 0 Chlorovirus glycoprotein repeat bZIP_1 PF00170.21 ORX69452.1 - 0.00029 20.9 11.5 0.00081 19.4 11.5 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX69452.1 - 0.022 14.8 12.8 0.042 13.9 12.8 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Draxin PF15550.6 ORX69452.1 - 0.05 13.5 1.5 0.097 12.5 1.5 1.4 1 0 0 1 1 1 0 Draxin bZIP_Maf PF03131.17 ORX69452.1 - 3.4 8.2 11.6 7.4 7.2 11.6 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor START PF01852.19 ORX69453.1 - 0.00047 19.6 9.5 0.0089 15.5 0.1 2.8 3 0 0 3 3 3 2 START domain adh_short PF00106.25 ORX69454.1 - 1.6e-22 79.9 0.1 2.2e-22 79.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX69454.1 - 4.9e-14 52.4 0.3 7.9e-14 51.8 0.3 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX69454.1 - 4.8e-05 23.3 0.3 0.0021 18.0 0.0 2.4 2 0 0 2 2 2 1 KR domain DUF4392 PF14336.6 ORX69454.1 - 0.034 13.6 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) baeRF_family10 PF18854.1 ORX69454.1 - 0.093 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 TFR_dimer PF04253.15 ORX69455.1 - 4e-28 97.9 0.0 7e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX69455.1 - 1.5e-21 77.0 0.0 2.9e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX69455.1 - 2.2e-10 40.4 0.0 5.2e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX69455.1 - 0.0055 16.4 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 F-box-like PF12937.7 ORX69456.1 - 0.00018 21.3 0.0 0.0006 19.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like Sortilin-Vps10 PF15902.5 ORX69457.1 - 0 1154.6 0.0 5.3e-112 374.8 0.0 4.6 3 2 1 4 4 4 4 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 ORX69457.1 - 1.6e-106 354.0 32.4 7.5e-39 133.8 3.5 4.0 4 0 0 4 4 4 3 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 ORX69457.1 - 8e-15 52.4 49.1 3.9 7.9 0.1 16.1 15 0 0 15 15 15 8 BNR/Asp-box repeat BNR_2 PF13088.6 ORX69457.1 - 7.9e-07 28.6 8.1 0.74 9.1 0.0 7.8 7 3 2 9 9 9 3 BNR repeat-like domain CHB_HEX_C PF03174.13 ORX69457.1 - 9.7e-07 28.7 0.5 0.61 10.1 0.0 6.0 6 0 0 6 6 6 2 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 ORX69457.1 - 5.2e-05 22.9 24.2 0.017 15.1 0.0 9.2 10 0 0 10 10 10 2 BNR-Asp box repeat PSII_BNR PF14870.6 ORX69457.1 - 0.0002 20.7 4.6 3 7.0 0.0 6.2 5 1 0 6 6 6 1 Photosynthesis system II assembly factor YCF48 DUF4185 PF13810.6 ORX69457.1 - 0.02 14.1 9.9 2.8 7.1 0.0 6.9 7 4 1 8 8 8 0 Domain of unknown function (DUF4185) Mo-co_dimer PF03404.16 ORX69457.1 - 0.72 9.9 9.2 12 5.9 0.0 5.8 8 0 0 8 8 8 0 Mo-co oxidoreductase dimerisation domain CHAP PF05257.16 ORX69458.1 - 3.7e-14 53.1 3.8 7e-14 52.2 3.8 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69458.1 - 1.8e-05 24.9 0.7 4.5e-05 23.6 0.1 2.0 2 1 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69459.1 - 2.9e-14 53.4 4.6 6.6e-14 52.2 4.6 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69459.1 - 0.00015 22.0 1.1 0.00025 21.3 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69460.1 - 2e-14 53.9 5.2 3.8e-14 53.0 5.2 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69460.1 - 1.3e-05 25.4 0.5 4e-05 23.8 0.1 2.0 2 1 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69461.1 - 4.9e-16 59.1 4.0 9.3e-16 58.2 4.0 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69461.1 - 0.0042 17.3 1.7 0.0075 16.5 0.1 2.3 2 1 0 2 2 2 1 Bacterial SH3 domain Phage_lysozyme PF00959.19 ORX69462.1 - 8.8e-15 55.1 0.0 1.5e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69462.1 - 3.5e-07 30.4 0.3 1.2e-06 28.6 0.3 2.0 1 0 0 1 1 1 1 Bacterial SH3 domain Forkhead PF00250.18 ORX69463.1 - 3.6e-30 104.1 0.0 4.2e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Forkhead domain adh_short PF00106.25 ORX69464.1 - 1.1e-36 126.2 0.2 1.4e-36 125.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX69464.1 - 7.6e-23 81.3 0.0 9.8e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX69464.1 - 1.1e-05 25.4 0.0 1.7e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ORX69464.1 - 0.0033 16.9 0.0 0.0047 16.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase SH3_9 PF14604.6 ORX69465.1 - 7.8e-34 115.3 7.2 4.1e-12 45.8 0.4 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ORX69465.1 - 8.3e-32 108.6 5.2 6.8e-10 38.4 0.1 3.6 3 0 0 3 3 3 3 SH3 domain SHD1 PF03983.12 ORX69465.1 - 1.8e-22 78.9 0.0 3.9e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 ORX69465.1 - 9.8e-21 73.2 0.0 2.3e-08 33.6 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_10 PF17902.1 ORX69465.1 - 0.0011 19.0 0.0 0.012 15.7 0.0 2.6 2 0 0 2 2 2 1 SH3 domain SAM_4 PF18017.1 ORX69465.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 ORX69466.1 - 1.7e-32 111.0 2.3 1.3e-15 57.0 0.2 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX69466.1 - 3.9e-32 109.6 2.4 2.2e-17 62.4 0.2 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ORX69466.1 - 1.3e-20 72.8 0.0 1.6e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 ORX69466.1 - 2.8e-20 72.3 0.0 5.5e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF5401 PF17380.2 ORX69466.1 - 0.025 12.7 36.2 0.047 11.8 36.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) TFIIA PF03153.13 ORX69466.1 - 0.12 12.4 40.8 0.25 11.3 40.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 ORX69466.1 - 3.9 6.4 20.8 5.5 5.9 20.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 ORX69466.1 - 5.5 5.6 17.6 8.7 5.0 17.6 1.3 1 0 0 1 1 1 0 Raftlin PMT PF02366.18 ORX69467.1 - 1.5e-79 267.0 22.5 1.5e-79 267.0 22.5 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX69467.1 - 1.1e-58 198.1 10.1 1.1e-58 198.1 10.1 3.1 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX69467.1 - 1.2e-07 31.7 6.8 2.4e-07 30.8 6.6 1.5 1 1 1 2 2 2 1 MIR domain DUF4239 PF14023.6 ORX69467.1 - 0.22 11.2 1.9 0.58 9.8 1.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Ribosomal_L19 PF01245.20 ORX69468.1 - 3e-20 72.2 0.1 4.8e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 NLPC_P60 PF00877.19 ORX69468.1 - 0.18 11.9 0.0 1.3 9.1 0.0 2.0 2 0 0 2 2 2 0 NlpC/P60 family Mito_carr PF00153.27 ORX69469.1 - 2.7e-59 197.1 3.2 4.7e-19 68.1 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Wzz PF02706.15 ORX69469.1 - 0.0026 18.0 0.1 0.022 15.1 0.1 2.4 2 0 0 2 2 2 1 Chain length determinant protein DUF4234 PF14018.6 ORX69469.1 - 0.09 12.9 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) PrcB_C PF14343.6 ORX69469.1 - 0.11 12.7 0.0 7.6 6.8 0.0 2.4 2 0 0 2 2 2 0 PrcB C-terminal DUF1729 PF08354.10 ORX69470.1 - 8.3e-139 462.4 0.0 2.1e-138 461.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX69470.1 - 6.4e-58 196.7 1.5 1.4e-57 195.6 0.0 2.4 3 0 0 3 3 2 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX69470.1 - 3.3e-56 190.1 0.0 6.8e-56 189.1 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX69470.1 - 5.2e-45 153.6 0.0 9.7e-45 152.7 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain FAS_meander PF17951.1 ORX69470.1 - 6.5e-27 94.1 0.0 1.2e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 ORX69470.1 - 1.1e-25 89.5 0.0 1.4e-23 82.8 0.0 2.9 2 0 0 2 2 2 1 MaoC like domain ketoacyl-synt PF00109.26 ORX69470.1 - 1.1e-22 80.8 0.4 2.9e-22 79.5 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX69470.1 - 4.3e-17 62.6 0.4 9.9e-17 61.5 0.1 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX69470.1 - 2.8e-14 53.2 0.0 6.7e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX69470.1 - 5.8e-13 49.1 0.0 5.3e-12 46.0 0.0 2.3 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX69470.1 - 6.4e-09 35.9 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Thiolase_N PF00108.23 ORX69470.1 - 0.11 11.8 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain NMO PF03060.15 ORX69470.1 - 0.23 10.8 1.4 0.85 8.9 0.4 2.3 2 1 0 2 2 2 0 Nitronate monooxygenase Biopterin_H PF00351.21 ORX69471.1 - 1e-128 429.0 0.1 1.2e-128 428.9 0.1 1.0 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Biopterin_H PF00351.21 ORX69472.1 - 6.8e-166 551.3 0.0 8.4e-166 551.0 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 ORX69472.1 - 4.7e-05 23.1 0.2 8.4e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 ORX69472.1 - 0.014 16.0 0.5 0.025 15.2 0.5 1.4 1 0 0 1 1 1 0 ACT domain RRM_1 PF00076.22 ORX69473.1 - 2.6e-07 30.4 0.0 2.8e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX69473.1 - 0.0003 20.8 0.0 0.0004 20.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif WD40 PF00400.32 ORX69474.1 - 2.3e-27 94.7 11.0 1.3e-06 29.0 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat PRP4 PF08799.11 ORX69474.1 - 1.3e-11 43.9 0.1 2.9e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 ORX69474.1 - 3.7e-10 40.0 0.0 0.00011 22.5 0.0 4.7 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX69474.1 - 0.0011 18.0 0.0 2.8 6.8 0.0 3.2 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX69474.1 - 0.049 13.5 0.0 0.34 10.8 0.0 2.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Tim44 PF04280.15 ORX69475.1 - 0.0055 16.8 0.1 0.011 15.8 0.1 1.5 1 0 0 1 1 1 1 Tim44-like domain Motile_Sperm PF00635.26 ORX69476.1 - 6.8e-13 48.4 0.0 9.4e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PfkB PF00294.24 ORX69477.1 - 5.8e-66 222.8 0.0 7.2e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ORX69477.1 - 0.039 13.3 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Metallophos PF00149.28 ORX69479.1 - 9e-15 55.7 0.0 1.9e-14 54.7 0.0 1.6 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX69479.1 - 0.00027 21.2 0.2 0.00064 19.9 0.2 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CTV_P23 PF04808.12 ORX69479.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Citrus tristeza virus (CTV) P23 protein DUF4551 PF15087.6 ORX69479.1 - 7 5.4 5.6 11 4.8 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_L2_C PF03947.18 ORX69480.1 - 9e-48 161.6 2.6 9e-48 161.6 2.6 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ORX69480.1 - 1.9e-24 85.4 0.3 4.5e-24 84.2 0.1 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain His_Phos_1 PF00300.22 ORX69481.1 - 5.3e-44 150.2 0.1 6.3e-44 150.0 0.1 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_1 PF00300.22 ORX69482.1 - 2e-43 148.4 0.1 2.3e-43 148.1 0.1 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 3HCDH_N PF02737.18 ORX69483.1 - 4e-55 186.5 0.1 5.5e-55 186.0 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ORX69483.1 - 5.1e-33 113.6 0.0 2.4e-32 111.4 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ORX69483.1 - 0.0011 19.2 0.1 0.0018 18.4 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ORX69483.1 - 0.0018 18.3 0.1 0.0028 17.6 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Mur_ligase PF01225.25 ORX69483.1 - 0.093 13.1 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Mur ligase family, catalytic domain AlaDh_PNT_C PF01262.21 ORX69483.1 - 0.12 11.7 0.4 0.19 11.0 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Coprogen_oxidas PF01218.18 ORX69484.1 - 9.5e-131 434.9 0.0 1.3e-130 434.4 0.0 1.2 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Pro_isomerase PF00160.21 ORX69485.1 - 4.5e-46 157.0 0.4 9e-46 156.0 0.2 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 ORX69485.1 - 5.2e-17 60.9 0.3 1.1e-06 28.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69485.1 - 7.8e-12 44.4 0.6 8.9e-05 22.3 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69485.1 - 2e-08 34.4 0.0 1.1e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69485.1 - 3.2e-08 33.2 0.4 0.00056 19.9 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69485.1 - 3.2e-06 26.7 2.7 0.039 13.6 0.1 3.4 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 ORX69485.1 - 1e-05 25.9 0.8 0.53 11.0 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69485.1 - 0.00031 21.3 0.8 0.097 13.3 0.3 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX69485.1 - 0.0012 19.0 0.4 2.5 8.3 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX69485.1 - 0.0037 17.2 0.4 4.7 7.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69485.1 - 0.0046 17.5 2.3 0.42 11.1 0.5 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ORX69485.1 - 0.011 15.0 0.2 0.038 13.2 0.1 1.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX69485.1 - 0.012 16.0 0.0 0.4 11.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69485.1 - 0.033 15.0 0.1 2.3 9.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX69485.1 - 0.39 11.0 4.7 2.2 8.6 0.2 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ABC_tran PF00005.27 ORX69486.1 - 5.6e-35 120.8 0.0 1.4e-18 67.7 0.1 2.8 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 ORX69486.1 - 1.5e-07 31.0 0.9 0.01 15.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX69486.1 - 5e-06 26.6 0.3 0.012 15.7 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX69486.1 - 7.1e-06 26.5 0.4 0.093 13.1 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX69486.1 - 1.9e-05 24.6 0.5 0.1 12.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 ORX69486.1 - 2.1e-05 25.1 0.7 0.14 12.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX69486.1 - 5.5e-05 23.4 0.6 1.1 9.5 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 ORX69486.1 - 0.00013 21.8 0.3 0.51 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 ORX69486.1 - 0.0004 20.3 0.2 0.34 10.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ORX69486.1 - 0.00058 20.4 0.1 0.1 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_membrane PF00664.23 ORX69486.1 - 0.0011 18.7 9.4 0.035 13.8 4.1 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region DUF87 PF01935.17 ORX69486.1 - 0.0026 17.9 1.3 0.01 16.0 0.1 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain DUF815 PF05673.13 ORX69486.1 - 0.0037 16.5 0.2 0.067 12.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) T2SSE PF00437.20 ORX69486.1 - 0.0047 16.0 0.3 0.57 9.2 0.1 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein MeaB PF03308.16 ORX69486.1 - 0.0074 15.3 0.5 0.78 8.7 0.1 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ORX69486.1 - 0.0077 16.7 0.4 2.8 8.4 0.2 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ORX69486.1 - 0.0082 16.1 1.4 0.45 10.4 0.2 2.5 2 0 0 2 2 2 1 NTPase SMC_N PF02463.19 ORX69486.1 - 0.01 15.3 0.6 1.3 8.4 0.1 2.6 3 0 0 3 3 2 1 RecF/RecN/SMC N terminal domain AAA_10 PF12846.7 ORX69486.1 - 0.015 14.3 0.4 0.19 10.6 0.1 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_25 PF13481.6 ORX69486.1 - 0.028 14.0 0.9 0.14 11.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ORX69486.1 - 0.043 13.4 1.6 3.1 7.3 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 ORX69486.1 - 0.049 13.8 0.3 2.1 8.6 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ORX69486.1 - 0.068 13.2 0.5 8.6 6.4 0.1 2.7 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 ORX69486.1 - 0.072 13.5 0.0 24 5.4 0.0 2.9 3 0 0 3 3 2 0 RNA helicase TsaE PF02367.17 ORX69486.1 - 0.075 13.0 0.6 14 5.7 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ORX69486.1 - 0.1 12.3 1.7 7 6.3 0.2 2.7 3 0 0 3 3 2 0 IstB-like ATP binding protein NACHT PF05729.12 ORX69486.1 - 0.11 12.4 3.3 3.6 7.5 0.3 2.8 3 0 0 3 3 2 0 NACHT domain ATP_bind_1 PF03029.17 ORX69486.1 - 0.12 12.1 0.9 16 5.2 0.3 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 ORX69486.1 - 0.13 11.8 0.2 4.9 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 ORX69486.1 - 0.18 11.4 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 ORX69486.1 - 0.22 11.4 0.2 1.8 8.5 0.1 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain Peptidase_M36 PF02128.15 ORX69487.1 - 8.3e-152 505.6 4.6 1.1e-151 505.2 4.6 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX69487.1 - 6.9e-12 45.0 0.6 2.7e-11 43.1 0.6 2.1 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX69487.1 - 0.0037 17.2 0.0 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX69487.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DPBB_1 PF03330.18 ORX69488.1 - 1.4e-05 25.2 0.0 2.6e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX69488.1 - 0.044 13.6 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Barwin family EndIII_4Fe-2S PF10576.9 ORX69488.1 - 0.12 12.8 4.2 0.19 12.1 0.2 2.3 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III DPBB_1 PF03330.18 ORX69489.1 - 3.4e-11 43.2 0.1 5.8e-11 42.5 0.1 1.4 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX69489.1 - 0.00075 19.3 0.1 0.001 18.9 0.1 1.3 1 1 0 1 1 1 1 Barwin family DPBB_1 PF03330.18 ORX69490.1 - 2.8e-10 40.3 0.3 1.2e-09 38.3 0.0 2.2 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 ORX69490.1 - 0.0012 18.7 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Barwin family DUF2367 PF10164.9 ORX69490.1 - 0.068 13.7 2.7 0.18 12.3 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) Complex1_LYR PF05347.15 ORX69491.1 - 1.3e-08 34.8 5.0 1.5e-08 34.6 0.1 2.9 3 0 0 3 3 3 1 Complex 1 protein (LYR family) PLN_propep PF16485.5 ORX69491.1 - 0.022 14.4 0.3 0.022 14.4 0.3 2.0 2 0 0 2 2 2 0 Protealysin propeptide LRR_RI_capping PF18779.1 ORX69491.1 - 0.096 12.4 1.1 0.16 11.7 0.2 1.8 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Complex1_LYR_2 PF13233.6 ORX69491.1 - 0.098 13.4 0.3 0.51 11.1 0.0 2.4 2 1 0 2 2 2 0 Complex1_LYR-like FlgM PF04316.13 ORX69491.1 - 0.12 12.7 0.0 31 5.0 0.5 2.6 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Aldedh PF00171.22 ORX69492.1 - 1.5e-111 373.2 0.0 1.9e-111 372.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldolase_II PF00596.21 ORX69493.1 - 3.5e-47 160.8 0.0 4.2e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PRA-PH PF01503.17 ORX69493.1 - 0.012 16.1 0.0 0.035 14.6 0.1 1.7 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase Ribosomal_L36 PF00444.18 ORX69494.1 - 2.4e-21 75.7 9.3 3.3e-21 75.2 9.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 DUF5389 PF17364.2 ORX69494.1 - 0.07 13.2 0.0 0.075 13.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5389) Ten1_2 PF15490.6 ORX69495.1 - 1.7e-21 76.1 0.0 2.3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit DUF4431 PF14485.6 ORX69495.1 - 0.031 14.1 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Rep_fac-A_3 PF08661.11 ORX69495.1 - 0.076 13.4 0.0 0.22 11.9 0.0 1.6 1 1 0 1 1 1 0 Replication factor A protein 3 Aldedh PF00171.22 ORX69496.1 - 1.3e-131 439.3 0.1 1.6e-131 439.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family L51_S25_CI-B8 PF05047.16 ORX69497.1 - 2e-12 46.9 0.0 2.6e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CMD PF02627.20 ORX69498.1 - 0.00094 19.2 0.8 0.079 13.0 0.1 2.4 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family Pkinase PF00069.25 ORX69499.1 - 1e-49 169.3 0.0 1.6e-49 168.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69499.1 - 5.9e-27 94.6 0.0 1e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX69499.1 - 0.00018 21.0 0.0 0.00057 19.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ORX69499.1 - 0.00072 19.2 0.1 0.0035 17.0 0.0 2.0 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 ORX69499.1 - 0.014 14.8 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 ORX69500.1 - 5.8e-15 54.9 0.0 1.1e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BUD22 PF09073.10 ORX69500.1 - 0.15 11.4 20.1 0.24 10.7 20.1 1.3 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ORX69500.1 - 0.19 9.9 16.4 0.25 9.5 16.4 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 ORX69500.1 - 1.9 7.0 22.6 3.4 6.2 22.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 ORX69500.1 - 6.7 4.9 9.9 8.7 4.5 9.9 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ORX69500.1 - 8.6 5.7 22.8 15 4.9 22.8 1.4 1 0 0 1 1 1 0 SDA1 A_deaminase PF00962.22 ORX69501.1 - 7.2e-109 364.1 0.0 1.1e-108 363.4 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Epsilon_antitox PF08998.11 ORX69501.1 - 0.14 12.5 0.2 12 6.3 0.0 2.7 2 0 0 2 2 2 0 Bacterial epsilon antitoxin DASH_Dad4 PF08650.10 ORX69502.1 - 2.6e-14 53.0 5.9 6.7e-13 48.4 5.9 2.0 1 1 0 1 1 1 1 DASH complex subunit Dad4 MRF_C1 PF13887.6 ORX69502.1 - 0.006 15.7 0.1 0.009 15.1 0.1 1.3 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 DASH_Dad1 PF08649.10 ORX69502.1 - 0.034 14.3 1.4 0.047 13.9 1.4 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad1 RNA_pol_Rpb1_1 PF04997.12 ORX69502.1 - 0.049 13.0 0.7 0.052 12.9 0.7 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 Ribul_P_3_epim PF00834.19 ORX69502.1 - 0.13 11.6 0.0 0.15 11.5 0.0 1.0 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family ARD PF03079.14 ORX69503.1 - 1.5e-50 171.4 0.2 1.8e-50 171.2 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 ORX69503.1 - 2.8e-10 39.8 0.0 4.4e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ORX69503.1 - 4.9e-06 26.5 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ORX69503.1 - 0.023 14.3 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Cupin HTH_32 PF13565.6 ORX69503.1 - 0.084 13.5 0.0 0.84 10.3 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain 3-HAO PF06052.12 ORX69503.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Myb_DNA-binding PF00249.31 ORX69504.1 - 5.4e-05 23.3 0.4 0.00019 21.6 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX69504.1 - 0.009 16.2 0.2 0.03 14.6 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF3421 PF11901.8 ORX69505.1 - 7.6e-28 96.8 0.5 1.2e-20 73.6 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) Actin PF00022.19 ORX69507.1 - 7.7e-115 383.7 0.0 3.2e-114 381.7 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ORX69507.1 - 0.0013 17.6 0.0 0.0031 16.4 0.0 1.6 1 1 0 1 1 1 1 MreB/Mbl protein Complex1_LYR PF05347.15 ORX69508.1 - 9e-05 22.5 0.8 9e-05 22.5 0.8 2.0 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX69508.1 - 0.00023 21.8 4.1 0.0019 18.9 0.2 2.6 3 0 0 3 3 3 2 Complex1_LYR-like DUF3421 PF11901.8 ORX69509.1 - 8.9e-40 135.3 6.8 1.2e-23 83.2 1.0 2.6 1 1 2 3 3 3 3 Protein of unknown function (DUF3421) Ribosomal_L27 PF01016.19 ORX69510.1 - 6.6e-36 122.2 1.0 8.9e-36 121.8 1.0 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein Rad1 PF02144.16 ORX69511.1 - 3e-63 213.5 0.0 3.4e-63 213.3 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Chromo PF00385.24 ORX69512.1 - 3.3e-10 39.7 0.3 1.9e-09 37.3 0.1 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.8 ORX69512.1 - 3e-06 26.6 0.0 4.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Helicase_C PF00271.31 ORX69512.1 - 0.001 19.4 0.0 0.0026 18.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Trs65 PF12735.7 ORX69513.1 - 1.4e-06 27.9 4.6 0.023 14.1 0.4 3.1 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 ADH_N PF08240.12 ORX69514.1 - 1.3e-22 79.7 4.1 2.5e-22 78.8 4.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX69514.1 - 8.7e-21 74.3 0.2 1.4e-20 73.6 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 ORX69514.1 - 0.0076 16.5 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 ORX69514.1 - 0.011 15.1 0.4 0.019 14.3 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX69514.1 - 0.03 13.9 0.1 0.043 13.4 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ORX69514.1 - 0.039 13.3 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Met_10 PF02475.16 ORX69514.1 - 0.074 12.8 0.3 0.13 12.0 0.3 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Imm70 PF15601.6 ORX69514.1 - 0.2 11.2 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 70 Fucosidase_C PF16757.5 ORX69515.1 - 0.049 14.2 0.2 0.08 13.5 0.2 1.3 1 0 0 1 1 1 0 Alpha-L-fucosidase C-terminal domain RNase_P_pop3 PF08228.11 ORX69516.1 - 8.8e-07 29.1 0.1 0.0066 16.5 0.0 3.2 3 0 0 3 3 3 2 RNase P subunit Pop3 AAA_11 PF13086.6 ORX69516.1 - 0.2 11.4 13.6 0.35 10.6 0.5 2.2 2 0 0 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 ORX69516.1 - 1.5 8.3 16.0 1.3 8.5 6.1 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Gti1_Pac2 PF09729.9 ORX69517.1 - 5.3e-40 137.4 0.8 3.3e-34 118.5 0.2 2.4 1 1 1 2 2 2 2 Gti1/Pac2 family Na_sulph_symp PF00939.19 ORX69519.1 - 3.4e-105 352.8 29.1 3.9e-105 352.6 29.1 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX69519.1 - 3.7e-13 49.3 31.0 3.7e-13 49.3 31.0 2.8 1 1 2 3 3 3 1 Citrate transporter zf-AN1 PF01428.16 ORX69519.1 - 0.031 14.4 1.4 0.05 13.8 1.4 1.3 1 0 0 1 1 1 0 AN1-like Zinc finger PADR1 PF08063.12 ORX69519.1 - 0.062 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 PADR1 (NUC008) domain COX15-CtaA PF02628.15 ORX69520.1 - 1.5e-98 329.9 6.5 1.7e-98 329.7 6.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein FKBP_C PF00254.28 ORX69521.1 - 5.8e-30 103.5 0.0 8.6e-30 102.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase BTHB PF18410.1 ORX69521.1 - 5.3e-28 96.6 0.7 9.2e-28 95.9 0.7 1.3 1 0 0 1 1 1 1 Basic tilted helix bundle domain Far-17a_AIG1 PF04750.14 ORX69522.1 - 0.0015 17.9 18.2 0.0023 17.3 18.2 1.3 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF4239 PF14023.6 ORX69522.1 - 0.21 11.3 3.4 6.1 6.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF498 PF04430.14 ORX69523.1 - 9.5e-23 80.3 0.0 1.2e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Sas10_Utp3 PF04000.15 ORX69524.1 - 5.9e-15 55.7 1.5 1.4e-14 54.5 0.1 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family CinA_KH PF18146.1 ORX69524.1 - 4 7.7 10.3 0.42 10.8 0.2 3.7 4 1 1 5 5 5 0 Damage-inducible protein CinA KH domain Methyltr_RsmB-F PF01189.17 ORX69525.1 - 2.1e-27 96.1 0.0 2e-17 63.5 0.0 2.2 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 ORX69525.1 - 4.3e-10 40.2 0.3 6.9e-07 29.9 0.0 3.5 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX69525.1 - 4.1e-08 33.2 0.0 3.5e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ORX69525.1 - 2.1e-06 27.7 0.0 5.3e-05 23.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ORX69525.1 - 3.4e-06 27.3 0.0 3.7e-05 23.9 0.0 2.2 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 ORX69525.1 - 2e-05 24.1 0.0 0.00034 20.0 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX69525.1 - 3.2e-05 24.5 0.0 0.18 12.5 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain PCMT PF01135.19 ORX69525.1 - 0.0077 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 ORX69525.1 - 0.01 16.6 0.0 3.5 8.4 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain MTS PF05175.14 ORX69525.1 - 0.017 14.7 0.0 0.26 10.8 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_3 PF01596.17 ORX69525.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_24 PF13578.6 ORX69525.1 - 0.081 13.9 0.1 1.7 9.7 0.1 2.5 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 ORX69525.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.12 ORX69525.1 - 0.18 11.3 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Sel1 PF08238.12 ORX69526.1 - 4.4e-19 68.5 23.5 4.8e-08 33.4 0.2 7.0 7 0 0 7 7 7 4 Sel1 repeat TPR_2 PF07719.17 ORX69526.1 - 0.0022 18.0 11.1 0.022 14.9 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69526.1 - 0.035 14.8 1.8 0.035 14.8 1.8 4.7 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69526.1 - 0.063 13.6 8.7 2.9 8.2 0.1 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69526.1 - 0.09 12.6 2.5 1.1 9.1 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69526.1 - 3.1 8.8 29.0 6.4 7.9 0.1 6.0 4 2 2 6 6 6 0 Tetratricopeptide repeat Peptidase_S28 PF05577.12 ORX69527.1 - 1.9e-42 145.6 0.0 2.2e-42 145.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 ORX69527.1 - 4.1e-05 23.0 0.0 5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 ORX69527.1 - 0.00011 21.1 0.0 0.00012 20.9 0.0 1.0 1 0 0 1 1 1 1 PS-10 peptidase S37 Esterase PF00756.20 ORX69527.1 - 0.019 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF3421 PF11901.8 ORX69528.1 - 1.3e-42 144.4 0.6 3.9e-28 97.8 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) DUF3421 PF11901.8 ORX69529.1 - 6.9e-32 109.8 0.2 1.2e-17 64.0 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) TSP_1 PF00090.19 ORX69529.1 - 0.035 14.3 0.5 0.074 13.3 0.1 1.8 2 0 0 2 2 2 0 Thrombospondin type 1 domain SRF-TF PF00319.18 ORX69530.1 - 2.7e-24 84.4 0.3 4.1e-24 83.8 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) ATP-synt_ab PF00006.25 ORX69531.1 - 1.9e-72 243.4 0.0 3.6e-72 242.5 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ORX69531.1 - 2.8e-49 166.6 0.3 4.9e-49 165.8 0.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ORX69531.1 - 1e-20 74.0 2.3 3e-20 72.5 2.3 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 ORX69531.1 - 0.018 15.2 1.4 0.054 13.6 0.3 2.2 1 1 1 2 2 2 0 HAS barrel domain Herpes_BLLF1 PF05109.13 ORX69531.1 - 0.072 11.1 0.5 0.1 10.6 0.5 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Ribosomal_L21p PF00829.21 ORX69532.1 - 5.8e-21 74.6 0.2 7.5e-21 74.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Glyco_hydro_18 PF00704.28 ORX69533.1 - 4e-61 207.4 0.6 4.6e-61 207.3 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Vps55 PF04133.14 ORX69534.1 - 4.5e-42 142.7 8.3 5e-42 142.5 8.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 ORX69534.1 - 6.4 7.3 6.2 7.2 7.1 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Pkinase PF00069.25 ORX69535.1 - 1.8e-67 227.5 0.0 2.1e-67 227.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69535.1 - 6e-30 104.4 0.0 8.4e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX69535.1 - 0.015 14.2 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Nkap_C PF06047.11 ORX69535.1 - 0.066 13.3 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 NF-kappa-B-activating protein C-terminal domain APH PF01636.23 ORX69535.1 - 0.097 12.6 0.0 0.79 9.6 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_C1_2 PF03051.15 ORX69536.1 - 2.5e-175 583.5 0.5 2.9e-175 583.3 0.5 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 ORX69536.1 - 9.1e-10 39.0 0.3 1.2e-05 25.5 0.7 3.0 3 0 0 3 3 3 2 Papain family cysteine protease FA_desaturase PF00487.24 ORX69538.1 - 2.1e-31 109.7 24.0 2.9e-31 109.2 24.0 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 ORX69538.1 - 1.4e-08 35.0 0.0 2.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) TAFII28 PF04719.14 ORX69539.1 - 3.9e-30 103.8 0.0 5.6e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Dcc1 PF09724.9 ORX69539.1 - 0.094 12.0 0.0 0.097 12.0 0.0 1.1 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 SPT2 PF08243.11 ORX69541.1 - 2.2e-18 66.8 19.1 2.9e-18 66.4 19.1 1.1 1 0 0 1 1 1 1 SPT2 chromatin protein RabGAP-TBC PF00566.18 ORX69543.1 - 2.6e-23 82.8 0.0 3.7e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase_fungal PF17667.1 ORX69544.1 - 3.5e-53 180.9 0.0 1.9e-27 96.1 0.0 2.3 1 1 0 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 ORX69544.1 - 0.00032 20.2 0.0 0.0034 16.8 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 ORX69544.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ORX69544.1 - 0.088 12.7 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX69545.1 - 4.7e-56 190.3 0.0 5.5e-30 104.5 0.0 2.6 2 1 0 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX69545.1 - 0.00056 19.4 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Arv1 PF04161.13 ORX69546.1 - 2.7e-56 191.1 3.7 3.5e-56 190.7 2.6 1.7 2 0 0 2 2 2 1 Arv1-like family UPF0242 PF06785.11 ORX69546.1 - 8.7 6.4 6.0 1.2 9.2 1.3 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cse1 PF08506.10 ORX69547.1 - 1.1e-138 462.1 1.8 1.7e-138 461.5 1.8 1.3 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 ORX69547.1 - 5e-125 417.5 0.5 2.8e-123 411.7 0.0 2.9 2 1 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 ORX69547.1 - 7e-15 54.7 0.1 7.2e-14 51.5 0.0 2.9 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 ORX69547.1 - 0.0036 17.4 2.9 0.21 11.7 0.0 4.2 4 2 0 4 4 4 1 Exportin 1-like protein RPAP3_C PF13877.6 ORX69547.1 - 0.076 13.6 0.2 1e+02 3.5 0.0 4.2 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 PE PF00934.20 ORX69547.1 - 1.1 9.7 6.0 8.6 6.8 0.1 3.4 3 0 0 3 3 3 0 PE family MIF4G PF02854.19 ORX69548.1 - 0.096 12.3 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 MIF4G domain Cyclin_N PF00134.23 ORX69549.1 - 8.3e-11 41.7 0.7 1.7e-10 40.7 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 ORX69549.1 - 1.2e-07 31.7 2.6 2.6e-05 24.2 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C PF02984.19 ORX69549.1 - 2.2e-06 27.8 0.5 3e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Chitin_synth_2 PF03142.15 ORX69550.1 - 2.4e-241 802.0 2.3 4.1e-241 801.2 2.3 1.4 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX69550.1 - 3.9e-126 422.0 0.0 2.4e-124 416.0 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_trans_2_3 PF13632.6 ORX69550.1 - 2e-11 44.2 4.5 4.5e-11 43.0 4.5 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX69550.1 - 1.1e-09 38.6 0.0 9.3e-09 35.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 ORX69550.1 - 8.1e-09 35.5 0.1 5.4e-05 23.3 0.0 3.9 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 ORX69550.1 - 1.9e-08 34.1 0.4 5.4e-08 32.6 0.4 1.8 1 0 0 1 1 1 1 DEK C terminal domain Glycos_transf_2 PF00535.26 ORX69550.1 - 6.7e-06 26.0 0.0 0.0053 16.6 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX69550.1 - 0.00031 20.2 0.1 0.00089 18.8 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 21 Wzy_C PF04932.15 ORX69550.1 - 0.1 12.2 0.1 3.9 7.1 0.0 3.0 2 1 1 3 3 3 0 O-Antigen ligase TFIIA PF03153.13 ORX69550.1 - 2.2 8.2 6.5 4.1 7.3 6.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DEAD PF00270.29 ORX69551.1 - 8.9e-48 162.4 0.0 2e-47 161.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX69551.1 - 9.3e-25 87.1 0.1 1.6e-22 79.9 0.1 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DBP10CT PF08147.12 ORX69551.1 - 9.9e-19 67.4 2.4 9.9e-19 67.4 2.4 2.4 2 0 0 2 2 2 1 DBP10CT (NUC160) domain Rep_fac_C PF08542.11 ORX69552.1 - 2e-20 73.0 0.0 6.8e-20 71.3 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 ORX69552.1 - 2.4e-17 63.6 0.0 4.4e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ORX69552.1 - 4.5e-14 52.6 0.0 7.5e-09 35.6 0.0 2.5 2 1 1 3 3 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 ORX69552.1 - 1.5e-08 34.8 0.0 4e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 ORX69552.1 - 4.8e-07 29.6 0.0 9.4e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX69552.1 - 6.3e-06 26.7 0.0 1.5e-05 25.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 ORX69552.1 - 8.3e-06 25.1 0.0 1.2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 ORX69552.1 - 1.4e-05 24.9 0.0 3.5e-05 23.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 ORX69552.1 - 1.4e-05 25.1 0.0 2.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX69552.1 - 2.9e-05 24.0 0.6 0.00033 20.5 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 ORX69552.1 - 6.4e-05 23.2 0.0 0.00017 21.9 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 ORX69552.1 - 0.00013 22.2 1.3 0.03 14.6 0.1 2.8 2 1 1 3 3 2 1 AAA domain AAA_24 PF13479.6 ORX69552.1 - 0.00025 20.8 0.0 0.0005 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ORX69552.1 - 0.00035 20.6 0.1 0.0013 18.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ORX69552.1 - 0.00037 20.4 0.0 0.00084 19.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 ORX69552.1 - 0.00067 20.0 0.1 0.0018 18.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 ORX69552.1 - 0.0016 18.2 0.3 0.022 14.5 0.0 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_7 PF12775.7 ORX69552.1 - 0.0023 17.5 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region ResIII PF04851.15 ORX69552.1 - 0.0023 18.0 0.0 0.015 15.3 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 ORX69552.1 - 0.0024 17.7 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DNA_pol3_delta PF06144.13 ORX69552.1 - 0.0025 17.6 0.0 0.0047 16.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_23 PF13476.6 ORX69552.1 - 0.0093 16.5 0.0 0.017 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX69552.1 - 0.015 15.9 0.0 0.03 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX69552.1 - 0.024 15.0 0.0 0.054 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 ORX69552.1 - 0.028 14.4 0.0 0.078 12.9 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 ORX69552.1 - 0.028 13.5 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 ORX69552.1 - 0.031 13.8 0.4 0.35 10.4 0.1 2.3 1 1 1 2 2 2 0 AAA domain TniB PF05621.11 ORX69552.1 - 0.041 13.3 0.0 1.3 8.4 0.0 2.1 1 1 1 2 2 2 0 Bacterial TniB protein SRP54 PF00448.22 ORX69552.1 - 0.047 13.3 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 ORX69552.1 - 0.048 13.0 0.0 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ORX69552.1 - 0.057 13.7 0.1 0.1 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 ORX69552.1 - 0.069 12.1 0.1 0.73 8.8 0.0 2.2 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TIP49 PF06068.13 ORX69552.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 ORX69552.1 - 0.089 13.0 0.2 0.28 11.4 0.2 1.9 2 1 0 2 2 1 0 AAA domain ABC_tran PF00005.27 ORX69552.1 - 0.09 13.3 0.0 0.19 12.2 0.0 1.7 1 1 0 1 1 1 0 ABC transporter MutS_III PF05192.18 ORX69552.1 - 0.1 12.8 0.1 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 MutS domain III IstB_IS21 PF01695.17 ORX69552.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 ORX69552.1 - 0.13 12.2 0.0 0.35 10.8 0.0 1.8 2 0 0 2 2 1 0 NTPase RecR PF02132.15 ORX69552.1 - 0.14 11.7 0.2 0.32 10.6 0.2 1.5 1 0 0 1 1 1 0 RecR protein PAP2 PF01569.21 ORX69553.1 - 2.7e-08 33.7 8.0 1.3e-06 28.2 3.6 3.1 1 1 1 2 2 2 2 PAP2 superfamily DUF212 PF02681.14 ORX69553.1 - 0.035 14.3 0.0 1.1 9.3 0.0 2.2 1 1 1 2 2 2 0 Divergent PAP2 family Thiamine_BP PF01910.17 ORX69554.1 - 7.3e-19 67.5 0.0 8.3e-19 67.3 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein Ribosomal_L5_C PF00673.21 ORX69555.1 - 2e-22 79.1 0.0 3e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ORX69555.1 - 1.3e-18 67.1 0.0 2.1e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 ORX69555.1 - 0.1 12.4 0.2 0.19 11.4 0.2 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Acetyltransf_1 PF00583.25 ORX69558.1 - 3.6e-13 49.8 0.0 4.5e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX69558.1 - 3.2e-11 43.3 0.0 1.3e-10 41.3 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX69558.1 - 2.9e-06 27.6 0.0 4.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX69558.1 - 0.0084 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ORX69558.1 - 0.049 13.7 0.0 0.22 11.6 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Npa1 PF11707.8 ORX69559.1 - 1.3e-55 189.1 0.0 2.8e-55 188.1 0.0 1.6 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 ORX69559.1 - 8.4e-29 100.6 0.4 3e-28 98.8 0.4 2.0 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 Clathrin PF00637.20 ORX69560.1 - 2.9e-195 640.0 21.4 1.2e-33 116.0 0.0 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 ORX69560.1 - 1.2e-29 102.0 2.2 4.8e-29 100.1 2.2 2.1 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.20 ORX69560.1 - 2.8e-25 87.3 0.4 2.2e-05 24.5 0.0 6.6 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin-link PF09268.10 ORX69560.1 - 1.5e-06 27.5 0.0 1.5e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Clathrin, heavy-chain linker TPR_14 PF13428.6 ORX69560.1 - 2.3e-06 27.9 6.0 17 6.6 0.0 9.4 9 1 1 10 10 10 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 ORX69560.1 - 1.3e-05 24.5 0.3 0.032 13.3 0.0 3.4 3 0 0 3 3 3 2 Coatomer WD associated region TPR_7 PF13176.6 ORX69560.1 - 0.0036 17.2 2.9 0.88 9.8 0.1 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69560.1 - 0.004 16.9 2.7 8.6 6.4 0.0 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69560.1 - 0.0089 16.1 8.4 1.9 8.8 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69560.1 - 0.22 11.8 8.0 0.93 9.9 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Glyco_hydro_31 PF01055.26 ORX69562.1 - 5.1e-157 523.6 0.4 5.1e-157 523.6 0.4 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX69562.1 - 2.3e-30 105.2 0.0 4.2e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX69562.1 - 0.00033 20.9 0.2 0.00086 19.6 0.2 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like Aminotran_1_2 PF00155.21 ORX69564.1 - 8.6e-47 160.1 0.0 1.1e-46 159.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX69564.1 - 0.049 12.1 0.0 0.092 11.3 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Complex1_LYR PF05347.15 ORX69565.1 - 1.9e-12 47.0 1.7 2.6e-12 46.6 1.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX69565.1 - 0.00078 20.1 0.7 0.00089 20.0 0.7 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Lum_binding PF00677.17 ORX69566.1 - 2.3e-46 155.7 0.0 1.3e-22 79.6 0.1 2.1 2 0 0 2 2 2 2 Lumazine binding domain YabP PF07873.11 ORX69566.1 - 0.058 13.2 0.0 10 6.0 0.0 2.8 2 1 0 2 2 2 0 YabP family Myb_DNA-binding PF00249.31 ORX69567.1 - 0.0032 17.6 0.2 0.006 16.8 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain HSP70 PF00012.20 ORX69568.1 - 1.4e-242 806.2 9.1 1.6e-242 806.0 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX69568.1 - 1.5e-18 66.7 0.6 3e-17 62.4 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 ORX69568.1 - 0.053 12.7 0.1 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 StbA protein Raco_middle PF17651.1 ORX69568.1 - 0.075 12.7 0.0 0.96 9.1 0.0 2.5 2 0 0 2 2 2 0 RACo middle region FtsA PF14450.6 ORX69568.1 - 5.9 7.4 5.7 50 4.4 0.0 3.6 3 2 0 3 3 3 0 Cell division protein FtsA COX5B PF01215.19 ORX69569.1 - 1.5e-36 124.9 0.0 1.9e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 ORX69569.1 - 0.0091 16.0 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger domain zinc_ribbon_5 PF13719.6 ORX69569.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain ATG_C PF09333.11 ORX69570.1 - 6.6e-32 109.7 0.2 2.1e-31 108.1 0.2 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 ORX69570.1 - 4.4e-19 68.7 2.0 6.8e-19 68.1 0.2 2.3 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 ORX69570.1 - 0.00051 19.9 0.0 0.0013 18.6 0.0 1.7 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal ATG2_CAD PF13329.6 ORX69570.1 - 0.0054 16.5 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13 PF16908.5 ORX69570.1 - 0.013 15.3 0.0 0.6 9.9 0.0 2.5 2 0 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal Mito_fiss_Elm1 PF06258.11 ORX69572.1 - 4.9e-13 48.9 0.0 8.4e-13 48.1 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial fission ELM1 PUCC PF03209.15 ORX69572.1 - 0.023 13.7 0.0 0.033 13.2 0.0 1.1 1 0 0 1 1 1 0 PUCC protein tRNA-synt_2d PF01409.20 ORX69573.1 - 7.4e-90 300.7 0.0 1.1e-89 300.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 ORX69573.1 - 2.4e-17 63.0 1.6 4.1e-17 62.2 0.3 2.1 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 ORX69573.1 - 1.2e-08 34.7 0.0 1.7e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ORX69573.1 - 0.00044 19.4 0.2 0.059 12.4 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD1 PF18552.1 ORX69573.1 - 0.0027 17.4 0.3 0.0099 15.6 0.1 2.1 2 0 0 2 2 2 1 PheRS DNA binding domain 1 tRNA-synt_2b PF00587.25 ORX69573.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TMP-TENI PF02581.17 ORX69573.1 - 0.047 13.0 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase BLACT_WH PF17778.1 ORX69573.1 - 2.2 8.3 4.0 23 5.1 0.1 3.2 3 1 1 4 4 4 0 Beta-lactamase associated winged helix domain HLH PF00010.26 ORX69575.1 - 1.5e-16 60.0 0.4 2.8e-16 59.2 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNase_P_Rpp14 PF01900.19 ORX69577.1 - 0.00026 21.2 0.0 0.00029 21.0 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family KH_8 PF17903.1 ORX69578.1 - 1.6e-32 111.4 0.0 5e-32 109.8 0.0 1.9 1 0 0 1 1 1 1 Krr1 KH1 domain DUF2514 PF10721.9 ORX69578.1 - 1 9.4 9.7 1.6 8.8 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) AAA_11 PF13086.6 ORX69578.1 - 2.7 7.7 10.6 4.3 7.0 10.6 1.4 1 0 0 1 1 1 0 AAA domain RIBIOP_C PF04950.12 ORX69579.1 - 8.2e-118 393.1 0.3 1.7e-117 392.0 0.0 1.7 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ORX69579.1 - 2.1e-25 88.6 0.0 6e-25 87.2 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain XAP5 PF04921.14 ORX69580.1 - 4.7e-76 255.9 6.4 4.7e-76 255.9 6.4 2.1 1 1 1 2 2 2 1 XAP5, circadian clock regulator DUF4604 PF15377.6 ORX69580.1 - 0.023 15.1 9.1 0.023 15.1 9.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) bZIP_2 PF07716.15 ORX69581.1 - 1.8e-05 24.7 13.9 1.8e-05 24.7 13.9 2.2 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX69581.1 - 0.14 12.2 16.4 0.28 11.3 13.6 2.2 2 0 0 2 2 2 0 bZIP transcription factor CR6_interact PF10147.9 ORX69581.1 - 4.2 7.0 14.5 0.16 11.7 8.5 1.6 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 His_Phos_2 PF00328.22 ORX69584.1 - 6.5e-24 85.0 0.0 3.3e-13 49.8 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Glyco_hydro_72 PF03198.14 ORX69585.1 - 3.3e-119 397.8 0.8 4.3e-119 397.4 0.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ORX69585.1 - 3.2e-12 46.9 2.4 7.4e-12 45.8 2.4 1.7 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 ORX69585.1 - 7.2e-05 22.0 0.4 0.00025 20.3 0.4 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 ORX69585.1 - 0.0006 19.3 0.5 0.021 14.2 0.3 2.2 1 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) AF-4 PF05110.13 ORX69585.1 - 3.5 5.6 16.7 5 5.1 16.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein IBN_N PF03810.19 ORX69586.1 - 1.2e-10 41.2 0.2 6.3e-10 38.8 0.2 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Bromodomain PF00439.25 ORX69587.1 - 3.9e-24 84.5 0.1 7.6e-24 83.6 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 ORX69587.1 - 4.8e-09 36.5 0.0 9.5e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX69587.1 - 7.3e-07 29.2 0.1 1.4e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX69587.1 - 5.6e-05 23.5 0.2 0.00011 22.6 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX69587.1 - 0.067 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein HMG_box PF00505.19 ORX69588.1 - 1.3e-19 70.3 0.4 2.6e-19 69.4 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX69588.1 - 1e-05 26.0 0.6 1e-05 26.0 0.6 1.8 2 0 0 2 2 2 1 HMG-box domain MATalpha_HMGbox PF04769.12 ORX69588.1 - 0.16 11.3 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Pex26 PF07163.12 ORX69589.1 - 0.2 10.9 0.1 0.27 10.5 0.1 1.1 1 0 0 1 1 1 0 Pex26 protein HMG_box PF00505.19 ORX69591.1 - 8.9e-13 48.5 1.1 1.6e-12 47.6 1.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX69591.1 - 0.00029 21.3 0.2 0.00051 20.6 0.2 1.4 1 0 0 1 1 1 1 HMG-box domain MukB_hinge PF16330.5 ORX69591.1 - 0.004 16.9 0.1 0.0079 15.9 0.1 1.4 1 0 0 1 1 1 1 MukB hinge domain RRM_1 PF00076.22 ORX69593.1 - 1.5e-14 53.6 0.0 2.1e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ORX69593.1 - 2e-06 27.6 3.5 2.7e-06 27.2 3.5 1.2 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 ORX69593.1 - 0.00066 19.3 0.0 0.00071 19.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX69593.1 - 0.017 15.2 0.0 0.021 14.9 0.0 1.1 1 0 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 ORX69593.1 - 0.026 14.4 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2129 PF09902.9 ORX69593.1 - 0.032 14.3 0.0 0.054 13.6 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2129) zf-CCHC_4 PF14392.6 ORX69593.1 - 0.057 13.2 0.4 0.092 12.5 0.4 1.3 1 0 0 1 1 1 0 Zinc knuckle DbpA PF03880.15 ORX69593.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 DbpA RNA binding domain DUF759 PF05537.11 ORX69593.1 - 0.091 11.6 0.0 0.094 11.6 0.0 1.0 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF759) UTP25 PF06862.12 ORX69594.1 - 1.9e-178 594.1 1.0 2.2e-178 593.9 1.0 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 BSP_II PF05432.11 ORX69594.1 - 0.0004 20.2 10.9 0.00064 19.5 10.9 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DEAD PF00270.29 ORX69594.1 - 0.0014 18.4 0.0 0.065 13.0 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF2895 PF11444.8 ORX69594.1 - 0.011 15.1 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) SDA1 PF05285.12 ORX69594.1 - 0.03 13.7 15.0 0.045 13.2 15.0 1.4 1 0 0 1 1 1 0 SDA1 TFIIA PF03153.13 ORX69594.1 - 0.92 9.4 13.1 1.5 8.7 13.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SET PF00856.28 ORX69594.1 - 1.8 8.9 4.5 6.3 7.2 4.5 1.9 1 1 0 1 1 1 0 SET domain ENTH PF01417.20 ORX69597.1 - 3.2e-43 146.7 0.0 4.8e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ORX69597.1 - 0.00076 18.6 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 ORX69597.1 - 0.025 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 VHS domain DUF1031 PF06275.11 ORX69597.1 - 0.097 12.9 0.2 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) Mitofilin PF09731.9 ORX69598.1 - 6.4e-66 223.5 37.7 2.2e-62 211.8 27.5 3.3 1 1 2 3 3 3 2 Mitochondrial inner membrane protein DUF4363 PF14276.6 ORX69598.1 - 0.17 12.0 4.2 20 5.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) Rav1p_C PF12234.8 ORX69599.1 - 3.8e-130 435.3 0.2 6.9e-128 427.8 0.0 2.1 2 0 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 ORX69599.1 - 0.00075 20.3 8.2 3.4 8.7 0.1 6.7 8 0 0 8 8 8 2 WD domain, G-beta repeat HPS6 PF15702.5 ORX69599.1 - 0.0032 15.6 0.0 0.0048 15.0 0.0 1.1 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 6 protein BolA PF01722.18 ORX69600.1 - 1.6e-08 34.7 0.0 4.3e-08 33.3 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein Pro_isomerase PF00160.21 ORX69601.1 - 9.1e-49 165.8 0.5 1e-48 165.6 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Dynactin PF12455.8 ORX69602.1 - 5.7e-56 189.9 6.3 5.7e-56 189.9 6.3 4.4 3 1 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 ORX69602.1 - 9.9e-25 86.4 0.5 3.8e-24 84.5 0.7 1.8 2 0 0 2 2 2 1 CAP-Gly domain MAD PF05557.13 ORX69602.1 - 0.0023 16.4 7.6 0.0023 16.4 7.6 3.9 2 1 1 3 3 3 1 Mitotic checkpoint protein GIT_CC PF16559.5 ORX69602.1 - 0.27 11.1 25.1 0.63 9.9 0.8 5.9 5 1 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor NPV_P10 PF05531.12 ORX69602.1 - 1.4 9.5 21.8 11 6.6 1.9 7.0 5 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein ANAPC10 PF03256.16 ORX69603.1 - 0.00021 21.0 0.0 0.0003 20.5 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 ORX69603.1 - 0.00029 20.9 0.0 0.00045 20.3 0.0 1.3 1 1 0 1 1 1 1 F5/8 type C domain PITH PF06201.13 ORX69603.1 - 0.0012 19.1 0.1 0.0019 18.4 0.1 1.4 1 1 0 1 1 1 1 PITH domain Sad1_UNC PF07738.13 ORX69603.1 - 0.015 15.4 0.1 0.28 11.2 0.1 2.1 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal Peptidase_M24 PF00557.24 ORX69604.1 - 8.3e-53 179.2 0.4 1e-52 178.9 0.4 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 ORX69604.1 - 3e-19 69.0 6.9 5.6e-19 68.2 6.9 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ORX69604.1 - 0.00025 21.0 6.6 0.00025 21.0 6.6 1.7 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 ORX69604.1 - 0.82 9.6 4.4 1.9 8.4 4.4 1.7 1 0 0 1 1 1 0 HIT zinc finger CCDC-167 PF15188.6 ORX69606.1 - 0.068 13.5 1.7 0.09 13.1 0.8 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Coiled-coil_56 PF09813.9 ORX69606.1 - 0.14 12.2 0.2 0.27 11.3 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 RNase_PH PF01138.21 ORX69607.1 - 2.6e-37 128.3 0.0 3.8e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX69607.1 - 2.3e-10 40.3 0.0 6.4e-10 38.9 0.0 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 TRAPPC-Trs85 PF12739.7 ORX69608.1 - 2.7e-75 253.9 5.8 4.5e-75 253.1 5.8 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SurE PF01975.17 ORX69609.1 - 7e-50 169.5 0.0 9.6e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE I-set PF07679.16 ORX69610.1 - 0.041 14.0 0.0 2 8.5 0.0 3.6 4 0 0 4 4 4 0 Immunoglobulin I-set domain COG5 PF10392.9 ORX69611.1 - 0.0001 22.5 1.6 0.00032 20.9 1.3 2.0 1 1 0 1 1 1 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 ORX69611.1 - 0.00061 19.7 1.6 0.0014 18.5 1.6 1.6 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain COG2 PF06148.11 ORX69611.1 - 0.081 13.0 6.7 0.17 12.0 4.2 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Laminin_II PF06009.12 ORX69611.1 - 0.32 11.0 3.2 0.29 11.1 1.3 1.9 2 0 0 2 2 2 0 Laminin Domain II ATG16 PF08614.11 ORX69611.1 - 0.89 9.7 8.1 0.16 12.2 4.2 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Glyco_hydro_47 PF01532.20 ORX69615.1 - 2.7e-142 474.9 0.0 3.2e-142 474.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 ORX69615.1 - 8.3e-06 25.6 0.1 0.0052 16.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ORX69615.1 - 0.00078 18.6 0.0 0.0063 15.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 GlcNAc_2-epim PF07221.11 ORX69615.1 - 0.034 13.4 0.0 4.8 6.3 0.0 2.7 3 0 0 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_127 PF07944.12 ORX69615.1 - 0.11 11.0 0.0 1.9 6.9 0.0 2.2 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 ORX69615.1 - 0.11 12.0 0.1 12 5.4 0.0 3.1 2 1 1 3 3 3 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_47 PF01532.20 ORX69616.1 - 2.8e-120 402.3 0.0 3.4e-120 402.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 ORX69616.1 - 0.00024 20.7 0.1 0.75 9.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 Ydr279_N PF17745.1 ORX69617.1 - 3e-09 37.0 0.0 6.4e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_H2-Ydr279 PF09468.10 ORX69617.1 - 6.2e-05 23.2 1.0 0.00013 22.2 1.0 1.5 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain His_Phos_1 PF00300.22 ORX69617.1 - 0.15 11.7 0.5 12 5.6 0.1 2.1 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 1) UPF0203 PF05254.12 ORX69619.1 - 4e-26 91.1 0.6 4.7e-26 90.8 0.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 ORX69619.1 - 9.4e-05 22.5 3.1 0.087 13.0 0.3 2.0 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein COX17 PF05051.13 ORX69619.1 - 0.012 15.9 0.8 0.033 14.5 0.8 1.6 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) COX6B PF02297.17 ORX69619.1 - 0.061 13.6 3.2 0.53 10.5 0.1 2.0 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 ORX69619.1 - 0.099 12.7 2.2 4.2 7.5 0.1 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like BCDHK_Adom3 PF10436.9 ORX69620.1 - 2.9e-43 147.5 0.1 6.1e-43 146.5 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX69620.1 - 6.7e-09 36.3 0.0 1.3e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Myb_DNA-binding PF00249.31 ORX69621.1 - 1.1e-10 41.5 0.0 2.5e-05 24.4 0.1 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX69621.1 - 6.9e-06 26.2 0.0 0.0014 18.8 0.0 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 ORX69621.1 - 0.00013 22.3 0.2 0.0079 16.6 0.1 2.4 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Cwf_Cwc_15 PF04889.12 ORX69621.1 - 0.21 11.3 9.3 0.54 10.0 9.3 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 ORX69621.1 - 7.5 5.6 18.8 0.042 13.0 5.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2457) Na_Ca_ex PF01699.24 ORX69622.1 - 5.7e-37 127.0 35.6 1.8e-20 73.5 16.0 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein HIG_1_N PF04588.13 ORX69623.1 - 1.2e-12 47.9 1.6 1.7e-12 47.4 1.6 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DNA_pol_B_N PF18094.1 ORX69626.1 - 0.12 12.9 0.1 0.15 12.6 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase beta N-terminal domain MT-A70 PF05063.14 ORX69627.1 - 4.4e-38 130.9 0.0 5.6e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 MT-A70 N6_N4_Mtase PF01555.18 ORX69627.1 - 0.00025 20.8 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 DNA methylase Cons_hypoth95 PF03602.15 ORX69627.1 - 0.019 14.6 0.0 0.059 13.0 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Ribosomal_L22e PF01776.17 ORX69628.1 - 1.7e-48 163.5 1.7 2.1e-48 163.2 1.7 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family MH2 PF03166.14 ORX69628.1 - 0.018 15.3 0.2 0.025 14.8 0.2 1.1 1 0 0 1 1 1 0 MH2 domain SAM_KSR1 PF13543.6 ORX69628.1 - 0.071 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 DUF167 PF02594.16 ORX69630.1 - 1.1e-24 86.3 0.3 1.8e-24 85.7 0.3 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 MFS_1 PF07690.16 ORX69631.1 - 7.3e-35 120.5 52.1 1.4e-34 119.6 50.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX69631.1 - 5.9e-13 48.1 25.5 7.8e-13 47.7 25.5 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX69631.1 - 5.1e-10 38.8 10.0 5.1e-10 38.8 10.0 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter PAP2 PF01569.21 ORX69633.1 - 3.5e-31 107.8 1.1 8.6e-31 106.5 1.1 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 ORX69633.1 - 0.051 13.2 8.0 0.16 11.6 8.0 2.1 1 1 0 1 1 1 0 PAP2 superfamily DUF3605 PF12239.8 ORX69634.1 - 1.2e-21 77.7 0.0 5.5e-21 75.5 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) Aconitase PF00330.20 ORX69635.1 - 9.9e-151 502.8 0.0 1.3e-150 502.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX69635.1 - 4.4e-36 124.1 0.0 7.8e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L7Ae PF01248.26 ORX69636.1 - 8.3e-23 79.9 1.3 1.8e-22 78.8 1.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 ORX69636.1 - 0.04 12.9 0.1 0.052 12.6 0.1 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Toprim_3 PF13362.6 ORX69636.1 - 0.081 13.3 0.1 0.19 12.1 0.1 1.7 1 1 0 1 1 1 0 Toprim domain HECT PF00632.25 ORX69637.1 - 5.6e-76 255.9 0.0 6.8e-76 255.7 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) peroxidase PF00141.23 ORX69638.1 - 9.6e-47 159.6 0.0 1.3e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DUF4307 PF14155.6 ORX69638.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) 3Beta_HSD PF01073.19 ORX69639.1 - 9.3e-62 208.6 0.0 1.2e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX69639.1 - 2e-32 112.6 0.1 2.7e-32 112.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX69639.1 - 2e-22 80.0 0.0 3e-21 76.2 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ORX69639.1 - 2.9e-14 52.8 0.1 7.7e-13 48.2 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ORX69639.1 - 1.2e-12 48.1 0.1 1.6e-12 47.7 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ORX69639.1 - 1e-11 44.5 0.0 1.3e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ORX69639.1 - 6.1e-09 35.4 0.3 2.2e-08 33.6 0.1 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 ORX69639.1 - 4.3e-06 26.7 1.0 3.3e-05 23.9 1.0 2.3 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 ORX69639.1 - 4.4e-05 23.2 0.2 6.5e-05 22.6 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 ORX69639.1 - 0.047 14.0 0.8 0.21 11.9 0.8 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UNC-93 PF05978.16 ORX69640.1 - 1.4e-13 50.9 9.6 1.4e-13 50.9 9.6 1.7 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ORX69640.1 - 3e-11 42.8 30.3 3.9e-11 42.5 29.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily 7TM-7TMR_HD PF07698.11 ORX69640.1 - 0.014 15.2 4.5 0.014 15.2 4.5 2.6 3 1 0 3 3 3 0 7TM receptor with intracellular HD hydrolase DUF4149 PF13664.6 ORX69640.1 - 2.1 8.7 11.0 0.67 10.3 3.4 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4149) Mem_trans PF03547.18 ORX69641.1 - 1.9e-34 118.7 9.9 4.4e-29 101.1 0.8 2.3 2 0 0 2 2 2 2 Membrane transport protein DUF4609 PF15382.6 ORX69641.1 - 0.26 11.2 0.8 0.52 10.2 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) RNA_pol_L_2 PF13656.6 ORX69642.1 - 4.4e-25 87.2 0.1 5.7e-25 86.9 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ORX69642.1 - 4.1e-09 35.7 0.0 6.7e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain UBX PF00789.20 ORX69643.1 - 2.1e-10 40.6 0.0 4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ORX69643.1 - 4.7e-08 32.7 0.0 1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 ORX69643.1 - 0.062 13.5 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like DUF4407 PF14362.6 ORX69643.1 - 0.42 9.9 11.5 0.82 9.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2828 PF11443.8 ORX69643.1 - 0.42 8.6 7.3 0.79 7.7 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 ORX69643.1 - 1.3 8.4 6.9 0.17 11.3 2.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) LigT_PEase PF02834.16 ORX69643.1 - 2 8.7 4.5 5.7 7.2 4.5 1.8 1 0 0 1 1 1 0 LigT like Phosphoesterase UNC-93 PF05978.16 ORX69644.1 - 1.3e-13 51.0 9.5 1.3e-13 51.0 9.5 1.7 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ORX69644.1 - 1.2e-11 44.1 29.0 3.4e-11 42.7 28.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily 7TM-7TMR_HD PF07698.11 ORX69644.1 - 0.014 15.1 4.5 0.014 15.1 4.5 2.6 3 1 0 3 3 3 0 7TM receptor with intracellular HD hydrolase DUF4149 PF13664.6 ORX69644.1 - 0.29 11.5 8.1 0.9 9.9 3.8 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) MFS_1 PF07690.16 ORX69645.1 - 2.2e-15 56.4 20.0 3.5e-13 49.2 20.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 ORX69645.1 - 3.3e-15 56.1 9.4 9.9e-15 54.6 9.4 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 7TM-7TMR_HD PF07698.11 ORX69645.1 - 0.0012 18.7 4.0 0.0012 18.7 4.0 3.0 3 1 0 3 3 3 1 7TM receptor with intracellular HD hydrolase DUF4149 PF13664.6 ORX69645.1 - 1.5 9.2 8.9 1 9.7 0.3 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4149) DUF1304 PF06993.12 ORX69645.1 - 4.3 7.4 11.6 4.4 7.3 2.7 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1304) UNC-93 PF05978.16 ORX69646.1 - 2.5e-14 53.3 9.4 6.9e-14 51.8 9.4 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ORX69646.1 - 1.6e-12 47.1 27.0 3.1e-12 46.1 26.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily GT87 PF09594.10 ORX69646.1 - 1.1 8.9 11.2 0.21 11.3 1.2 3.2 3 0 0 3 3 3 0 Glycosyltransferase family 87 DUF4149 PF13664.6 ORX69646.1 - 1.2 9.5 7.9 0.97 9.8 0.2 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4149) 7TM-7TMR_HD PF07698.11 ORX69646.1 - 3.4 7.4 12.2 0.071 12.9 3.8 2.5 3 1 0 3 3 3 0 7TM receptor with intracellular HD hydrolase DUF3808 PF10300.9 ORX69647.1 - 9.9e-77 258.7 0.1 1.3e-76 258.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 ORX69647.1 - 0.031 14.9 0.0 8.8 7.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat 3-HAO PF06052.12 ORX69648.1 - 2.5e-55 186.2 0.1 2.9e-55 186.1 0.1 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_1 PF00190.22 ORX69648.1 - 4.3e-05 23.2 0.1 6e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 ORX69648.1 - 5.4e-05 22.8 0.0 9.1e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Phage_Treg PF04761.12 ORX69648.1 - 0.00043 20.3 0.0 0.00066 19.7 0.0 1.2 1 0 0 1 1 1 1 Lactococcus bacteriophage putative transcription regulator Nudix_N_2 PF14803.6 ORX69648.1 - 0.019 14.9 0.5 2.6 8.0 0.1 3.0 3 0 0 3 3 3 0 Nudix N-terminal Cupin_8 PF13621.6 ORX69648.1 - 0.034 13.9 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Cupin-like domain DZR PF12773.7 ORX69648.1 - 0.059 13.4 1.6 0.27 11.3 1.6 1.9 1 1 1 2 2 2 0 Double zinc ribbon DUF1748 PF08520.10 ORX69649.1 - 1.5e-22 79.2 0.0 1.7e-22 79.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Spore_III_AB PF09548.10 ORX69649.1 - 0.032 14.3 0.0 0.036 14.2 0.0 1.0 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Rad21_Rec8 PF04824.16 ORX69650.1 - 0.13 11.5 0.0 0.34 10.2 0.0 1.6 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein Leader_Trp PF08255.11 ORX69650.1 - 0.25 11.4 3.6 0.4 10.8 0.8 2.8 2 1 1 3 3 3 0 Trp-operon Leader Peptide Myb_DNA-bind_6 PF13921.6 ORX69651.1 - 7.9e-20 70.9 9.0 0.00028 21.1 0.1 6.7 6 1 1 7 7 7 4 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX69651.1 - 1.3e-14 54.1 19.7 6.8e-05 23.0 0.1 7.5 8 1 0 8 8 8 3 Myb-like DNA-binding domain GcrA PF07750.11 ORX69651.1 - 0.00027 21.4 0.0 0.037 14.5 0.0 2.6 2 0 0 2 2 2 1 GcrA cell cycle regulator HTH_7 PF02796.15 ORX69651.1 - 0.056 13.5 0.0 3.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_11 PF08279.12 ORX69651.1 - 0.13 12.3 0.1 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 HTH domain HMG_box PF00505.19 ORX69652.1 - 9.5e-27 93.2 4.0 3.8e-08 33.6 0.1 3.6 4 0 0 4 4 4 3 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX69652.1 - 3e-12 47.0 7.7 0.0005 20.6 0.2 4.2 4 0 0 4 4 4 3 HMG-box domain Exonuc_VIII PF06630.11 ORX69652.1 - 0.11 12.3 0.8 0.22 11.3 0.8 1.4 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII F-box-like PF12937.7 ORX69653.1 - 0.013 15.4 1.1 0.051 13.5 0.0 2.4 3 0 0 3 3 3 0 F-box-like F-box PF00646.33 ORX69653.1 - 0.066 13.1 0.6 0.29 11.1 0.0 2.4 3 0 0 3 3 3 0 F-box domain DUF1242 PF06842.12 ORX69653.1 - 0.84 9.5 2.7 1.9 8.4 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1242) COPI_assoc PF08507.10 ORX69654.1 - 2.3e-13 50.3 13.8 3.2e-13 49.8 13.8 1.2 1 0 0 1 1 1 1 COPI associated protein RNase_PH PF01138.21 ORX69655.1 - 7.4e-24 84.7 0.1 1.4e-23 83.8 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX69655.1 - 4.6e-05 23.4 0.0 8.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF5421 PF17458.2 ORX69655.1 - 0.058 12.8 0.1 0.084 12.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) Thioredox_DsbH PF03190.15 ORX69655.1 - 0.06 13.3 0.0 0.078 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Bac_globin PF01152.21 ORX69655.1 - 0.071 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial-like globin Sds3 PF08598.11 ORX69656.1 - 2.9e-20 73.2 0.2 4e-20 72.8 0.2 1.2 1 0 0 1 1 1 1 Sds3-like DUF1351 PF07083.11 ORX69656.1 - 0.19 11.4 4.2 4.4 7.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) DUF3958 PF13125.6 ORX69656.1 - 0.7 10.1 8.9 2.7 8.2 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) WXG100 PF06013.12 ORX69656.1 - 1.9 8.8 6.5 4 7.7 0.3 3.1 2 1 0 3 3 3 0 Proteins of 100 residues with WXG PAP2 PF01569.21 ORX69657.1 - 5.1e-27 94.3 0.3 5.1e-27 94.3 0.3 1.8 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ORX69657.1 - 0.00017 21.4 3.5 0.00054 19.7 3.5 1.8 1 1 0 1 1 1 1 PAP2 superfamily MscS_TM PF12794.7 ORX69657.1 - 0.054 12.3 0.4 0.1 11.4 0.1 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF805 PF05656.14 ORX69657.1 - 0.065 13.6 2.6 0.1 13.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) RseC_MucC PF04246.12 ORX69657.1 - 0.072 13.0 0.6 0.43 10.5 0.1 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC FtsX PF02687.21 ORX69657.1 - 0.2 12.1 6.3 0.34 11.4 0.3 3.2 5 0 0 5 5 5 0 FtsX-like permease family MNHE PF01899.16 ORX69657.1 - 0.23 11.2 2.5 3.7 7.3 0.0 2.7 2 1 1 3 3 3 0 Na+/H+ ion antiporter subunit DUF996 PF06195.13 ORX69657.1 - 1.7 8.9 7.1 1.1 9.6 1.7 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF996) PPR_2 PF13041.6 ORX69658.1 - 0.011 15.9 0.0 0.17 12.1 0.0 2.4 2 0 0 2 2 2 0 PPR repeat family DUF2456 PF10445.9 ORX69658.1 - 0.11 12.6 0.7 0.23 11.6 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) VID27 PF08553.10 ORX69659.1 - 8.9e-147 488.8 0.0 1.2e-146 488.4 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 ORX69659.1 - 8.5e-32 110.4 0.0 8.5e-32 110.4 0.0 3.5 3 0 0 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 ORX69659.1 - 2.1e-25 89.1 0.7 4.2e-25 88.2 0.3 1.8 2 0 0 2 2 2 1 VID27 PH-like domain BUD22 PF09073.10 ORX69659.1 - 5.2 6.3 18.5 0.87 8.9 14.5 1.6 2 0 0 2 2 2 0 BUD22 6PF2K PF01591.18 ORX69660.1 - 3e-75 252.4 0.2 3.8e-75 252.0 0.2 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX69660.1 - 6.6e-38 130.4 0.0 9e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PIP49_N PF14875.6 ORX69660.1 - 0.054 13.4 0.2 0.28 11.1 0.2 2.0 1 1 0 1 1 1 0 N-term cysteine-rich ER, FAM69 AAA_33 PF13671.6 ORX69660.1 - 0.055 13.6 0.0 0.14 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Protoglobin PF11563.8 ORX69662.1 - 1.6e-41 141.9 0.3 1.8e-41 141.7 0.3 1.0 1 0 0 1 1 1 1 Protoglobin PAC4 PF16093.5 ORX69663.1 - 8.2e-08 32.3 0.1 1.9e-07 31.2 0.0 1.7 2 0 0 2 2 2 1 Proteasome assembly chaperone 4 CRAL_TRIO PF00650.20 ORX69664.1 - 6.3e-30 104.0 0.0 7.9e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CYSTM PF12734.7 ORX69665.1 - 4.8e-05 23.6 5.0 4.8e-05 23.6 5.0 3.2 2 1 1 3 3 3 2 Cysteine-rich TM module stress tolerance Cpn60_TCP1 PF00118.24 ORX69667.1 - 6.8e-145 483.4 7.9 7.8e-145 483.2 7.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mdv1 PF11542.8 ORX69667.1 - 0.035 14.0 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial division protein 1 PI3Ka PF00613.20 ORX69668.1 - 3.3e-60 202.7 0.3 5.9e-60 201.8 0.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ORX69668.1 - 4e-47 161.1 0.0 1.4e-32 113.5 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ORX69668.1 - 2.2e-19 69.7 0.0 4.1e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 ORX69668.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF1778 PF08681.11 ORX69668.1 - 8.9 6.3 6.6 19 5.3 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1778) RRM_1 PF00076.22 ORX69669.1 - 7.7e-13 48.1 0.0 1.2e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX69669.1 - 0.00014 22.4 9.1 0.00014 22.4 9.1 3.4 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 DUF2059 PF09832.9 ORX69669.1 - 6.2 7.0 7.5 13 5.9 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2059) RRM_1 PF00076.22 ORX69670.1 - 1.4e-15 56.8 0.0 2e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX69670.1 - 6.5e-09 36.2 13.0 6.5e-09 36.2 13.0 1.7 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 SAM_4 PF18017.1 ORX69672.1 - 0.091 12.7 4.7 45 4.1 0.0 6.2 8 0 0 8 8 8 0 SAM domain (Sterile alpha motif) Glyco_hydro_79n PF03662.14 ORX69672.1 - 0.43 9.5 7.5 1.4e+02 1.2 0.0 6.1 8 0 0 8 8 8 0 Glycosyl hydrolase family 79, N-terminal domain DUF4272 PF14094.6 ORX69674.1 - 6.4e-07 28.8 4.1 2e-06 27.2 0.2 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4272) RNB PF00773.19 ORX69675.1 - 5.2e-51 173.9 0.0 1.4e-50 172.5 0.0 1.7 2 0 0 2 2 2 1 RNB domain zf-RING_2 PF13639.6 ORX69676.1 - 1.9e-12 47.3 4.1 2.6e-12 46.9 4.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX69676.1 - 8.3e-11 41.4 1.2 8.3e-11 41.4 1.2 1.6 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX69676.1 - 8.4e-09 35.1 4.0 1.3e-08 34.6 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX69676.1 - 3.1e-08 33.8 7.5 1.5e-07 31.6 7.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX69676.1 - 4.6e-07 29.7 3.0 6.7e-07 29.2 3.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX69676.1 - 7.8e-07 28.9 2.4 1.2e-06 28.3 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX69676.1 - 1.4e-05 25.0 0.5 2.5e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX69676.1 - 0.00012 21.8 2.0 0.00019 21.2 2.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX69676.1 - 0.00069 19.4 3.2 0.00098 18.9 3.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX69676.1 - 0.00081 19.4 2.8 0.0022 18.0 2.8 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX69676.1 - 0.012 15.3 3.4 0.019 14.6 3.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 ORX69676.1 - 0.014 15.3 2.8 0.023 14.6 2.8 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 ORX69676.1 - 0.014 15.5 2.3 0.036 14.2 2.3 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 ORX69676.1 - 0.021 15.0 3.9 0.044 13.9 3.8 1.6 1 1 0 1 1 1 0 RING-variant domain zf-HC5HC2H PF13771.6 ORX69676.1 - 0.077 13.3 0.7 0.077 13.3 0.7 1.8 1 1 0 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX69676.1 - 0.096 12.9 2.4 0.2 11.8 2.5 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING-like PF08746.11 ORX69676.1 - 0.12 12.7 3.4 0.19 12.1 3.4 1.3 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 ORX69676.1 - 0.37 11.0 6.0 5.3 7.3 6.0 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain C1_1 PF00130.22 ORX69676.1 - 1.8 8.5 5.3 5.1 7.1 2.0 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3H2C3 PF17122.5 ORX69676.1 - 8.8 6.5 10.3 1.5 8.9 4.9 2.3 2 1 0 2 2 2 0 Zinc-finger Oxysterol_BP PF01237.18 ORX69677.1 - 4.6e-68 229.8 2.8 8e-66 222.4 2.8 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Methyltransf_34 PF11312.8 ORX69678.1 - 4.2e-49 167.4 0.1 1.1e-48 166.1 0.1 1.7 1 1 0 1 1 1 1 Putative SAM-dependent methyltransferase EF1G PF00647.19 ORX69679.1 - 1.8e-44 150.1 0.6 3.1e-44 149.4 0.6 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 ORX69679.1 - 1.8e-09 37.8 0.0 8.4e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX69679.1 - 2.2e-08 34.2 1.7 3.9e-08 33.4 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX69679.1 - 1.8e-07 31.4 0.0 2.8e-06 27.6 0.0 2.3 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX69679.1 - 5.2e-06 26.4 0.1 1.4e-05 25.0 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX69679.1 - 0.00015 21.8 1.5 0.00023 21.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX69679.1 - 0.0047 17.2 0.0 0.013 15.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Mitofilin PF09731.9 ORX69679.1 - 0.36 9.6 8.2 0.52 9.1 8.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FAP PF07174.11 ORX69679.1 - 0.44 10.0 5.7 0.7 9.3 5.7 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) GCD14 PF08704.10 ORX69680.1 - 4.8e-94 314.6 0.0 6e-94 314.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 ORX69680.1 - 8.7e-06 25.6 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 ORX69680.1 - 0.0037 17.1 0.0 0.015 15.1 0.0 2.0 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term PCMT PF01135.19 ORX69680.1 - 0.014 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Gcd10p PF04189.13 ORX69680.1 - 0.062 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Gcd10p family SAM_4 PF18017.1 ORX69681.1 - 0.051 13.6 1.2 39 4.3 0.0 4.9 6 0 0 6 6 6 0 SAM domain (Sterile alpha motif) tRNA-synt_2 PF00152.20 ORX69682.1 - 2.9e-88 296.0 0.0 3.6e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX69682.1 - 2.3e-10 40.3 0.0 4.4e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DEAD PF00270.29 ORX69683.1 - 4.5e-51 173.1 0.0 9e-51 172.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX69683.1 - 1.2e-30 106.1 0.1 2.7e-27 95.3 0.1 2.7 2 1 0 3 3 3 2 Helicase conserved C-terminal domain CMS1 PF14617.6 ORX69683.1 - 0.0013 18.1 13.1 0.018 14.4 0.0 2.4 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 ORX69683.1 - 0.003 16.8 0.0 0.003 16.8 0.0 2.3 2 0 0 2 2 1 1 ERCC3/RAD25/XPB C-terminal helicase Zip PF02535.22 ORX69683.1 - 0.045 13.0 1.0 0.056 12.7 1.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.17 ORX69683.1 - 0.068 13.3 1.4 0.1 12.8 1.4 1.3 1 0 0 1 1 1 0 DDHD domain SET PF00856.28 ORX69683.1 - 0.073 13.4 1.0 0.16 12.3 1.0 1.5 1 0 0 1 1 1 0 SET domain Dynactin_p62 PF05502.13 ORX69683.1 - 0.11 11.2 9.0 0.18 10.5 9.0 1.3 1 0 0 1 1 1 0 Dynactin p62 family Menin PF05053.13 ORX69683.1 - 0.41 9.0 6.7 0.57 8.5 6.7 1.1 1 0 0 1 1 1 0 Menin Tim54 PF11711.8 ORX69683.1 - 1.1 8.0 12.3 1.8 7.3 12.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AAA_22 PF13401.6 ORX69683.1 - 1.4 9.2 4.6 4.8 7.5 1.5 3.1 2 1 1 3 3 2 0 AAA domain AP3D1 PF06375.11 ORX69683.1 - 2.5 8.3 25.0 5.4 7.2 25.0 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TERB2 PF15101.6 ORX69683.1 - 3.5 7.6 11.0 6.1 6.8 11.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1764 PF08576.10 ORX69683.1 - 3.5 8.6 21.1 11 7.0 21.1 1.8 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF2151 PF10221.9 ORX69683.1 - 4.5 5.8 11.6 6.1 5.3 11.6 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator GAGA_bind PF06217.12 ORX69683.1 - 4.7 7.4 14.1 9.2 6.4 14.1 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Eapp_C PF10238.9 ORX69683.1 - 4.7 7.3 12.2 9.2 6.3 12.2 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF2722 PF10846.8 ORX69683.1 - 4.9 6.0 16.1 7.4 5.4 16.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SLC12 PF03522.15 ORX69683.1 - 5.4 5.9 10.9 8.3 5.3 10.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Vfa1 PF08432.10 ORX69683.1 - 5.7 7.2 28.0 12 6.2 28.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DHHW PF14286.6 ORX69683.1 - 5.8 6.1 7.8 9.1 5.5 7.8 1.2 1 0 0 1 1 1 0 DHHW protein RR_TM4-6 PF06459.12 ORX69683.1 - 7.8 6.2 18.6 13 5.5 18.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 ORX69683.1 - 8 6.9 11.8 17 5.9 10.7 2.0 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Aa_trans PF01490.18 ORX69684.1 - 2.8e-60 204.1 23.5 3.2e-60 204.0 23.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Proteasome PF00227.26 ORX69685.1 - 1.2e-48 165.2 0.2 1.2e-48 165.2 0.2 1.4 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX69685.1 - 2.7e-14 52.5 0.2 5e-14 51.7 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature MWFE PF15879.5 ORX69686.1 - 4e-16 58.9 0.0 6.1e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit BUD22 PF09073.10 ORX69686.1 - 5.8e-06 25.9 48.1 7.8e-06 25.5 48.1 1.2 1 0 0 1 1 1 1 BUD22 PPP4R2 PF09184.11 ORX69686.1 - 3.6 7.1 38.2 4.6 6.7 38.2 1.2 1 0 0 1 1 1 0 PPP4R2 Suc_Fer-like PF06999.12 ORX69688.1 - 2.6e-26 92.7 0.0 3.3e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like HIT PF01230.23 ORX69689.1 - 2.1e-23 82.9 0.0 3.1e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX69689.1 - 7.9e-06 26.3 0.0 1.1e-05 25.9 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding PI3_PI4_kinase PF00454.27 ORX69690.1 - 4.5e-41 141.3 0.0 9.9e-39 133.6 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ORX69690.1 - 5.7e-20 71.5 0.0 1.5e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ORX69690.1 - 0.016 14.5 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Toxin_5 PF05294.13 ORX69691.1 - 0.031 14.7 5.0 0.098 13.1 5.0 1.8 1 0 0 1 1 1 0 Scorpion short toxin COQ9 PF08511.11 ORX69692.1 - 4.9e-27 93.5 0.2 1.1e-26 92.3 0.2 1.6 1 0 0 1 1 1 1 COQ9 DUF2370 PF10176.9 ORX69693.1 - 2.9e-51 174.3 1.0 4e-49 167.3 1.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2370) LIM PF00412.22 ORX69695.1 - 1.9e-07 31.2 7.2 3.4e-07 30.4 7.2 1.4 1 0 0 1 1 1 1 LIM domain SMAP PF15477.6 ORX69695.1 - 0.74 10.8 5.2 4.5 8.3 5.2 2.4 1 0 0 1 1 1 0 Small acidic protein family F-box-like PF12937.7 ORX69696.1 - 0.062 13.2 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 F-box-like CUE PF02845.16 ORX69697.1 - 1.1e-08 34.6 0.0 0.0041 16.8 0.1 2.7 2 0 0 2 2 2 2 CUE domain Smr PF01713.21 ORX69697.1 - 4.8e-06 26.8 0.0 2e-05 24.9 0.0 2.1 1 0 0 1 1 1 1 Smr domain DUF1771 PF08590.10 ORX69697.1 - 1.3e-05 25.5 8.1 1.3e-05 25.5 8.1 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Bul1_C PF04426.12 ORX69697.1 - 0.00096 18.6 1.3 0.00096 18.6 1.3 1.9 3 0 0 3 3 3 1 Bul1 C terminus Maf1 PF09174.10 ORX69697.1 - 0.34 11.0 3.6 0.27 11.4 0.5 2.2 2 1 0 2 2 2 0 Maf1 regulator Syntaxin-18_N PF10496.9 ORX69697.1 - 3.3 8.0 6.6 0.7 10.2 2.3 2.2 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Ran_BP1 PF00638.18 ORX69698.1 - 5e-15 55.8 0.2 1e-14 54.8 0.2 1.5 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 ORX69698.1 - 3.4e-13 50.0 13.5 3.4e-13 50.0 13.5 7.1 5 2 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) RRM_1 PF00076.22 ORX69699.1 - 2.6e-13 49.6 0.0 3.2e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ORX69699.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 RL domain Nup35_RRM_2 PF14605.6 ORX69699.1 - 0.027 14.5 0.7 0.066 13.2 0.7 1.7 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 ORX69699.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HIT PF01230.23 ORX69700.1 - 1.4e-23 83.5 0.0 2e-23 83.0 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX69700.1 - 1.1e-05 25.9 0.0 1.6e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Suc_Fer-like PF06999.12 ORX69701.1 - 1.6e-26 93.4 0.0 1.9e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like PI3_PI4_kinase PF00454.27 ORX69702.1 - 1.4e-64 218.3 0.0 2.4e-64 217.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ORX69702.1 - 5e-59 200.3 4.8 5.2e-58 196.9 1.3 3.1 2 1 0 2 2 2 1 FAT domain DUF3385 PF11865.8 ORX69702.1 - 3.1e-29 102.0 6.1 6.1e-27 94.5 0.0 4.5 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 ORX69702.1 - 4.1e-21 75.2 1.5 1.2e-20 73.7 0.1 2.7 2 0 0 2 2 1 1 FKBP12-rapamycin binding domain FATC PF02260.20 ORX69702.1 - 7e-13 48.2 0.2 1.7e-12 46.9 0.2 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 ORX69702.1 - 4.3e-11 43.1 31.1 3.9e-05 23.9 0.9 9.4 8 1 0 8 8 7 3 HEAT repeats HEAT PF02985.22 ORX69702.1 - 4.6e-11 42.0 17.5 0.051 13.9 0.0 8.7 9 0 0 9 9 7 4 HEAT repeat Adaptin_N PF01602.20 ORX69702.1 - 0.00086 18.0 13.3 0.013 14.1 2.1 4.2 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 ORX69702.1 - 0.0058 16.7 0.5 0.15 12.1 0.1 3.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TAN PF11640.8 ORX69702.1 - 0.019 15.1 0.8 0.096 12.8 0.8 2.3 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Vac14_Fab1_bd PF12755.7 ORX69702.1 - 0.021 15.4 0.1 3.9 8.1 0.0 4.4 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Cnd3 PF12719.7 ORX69702.1 - 0.034 13.3 2.9 0.13 11.4 0.4 2.8 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 ORX69702.1 - 0.14 12.4 4.6 4.7 7.4 0.0 4.6 6 1 0 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ORX69702.1 - 0.16 12.5 52.1 1.8 9.1 0.0 13.0 13 4 3 16 16 16 0 HEAT-like repeat HrpB1_HrpK PF09613.10 ORX69702.1 - 3.3 7.4 6.9 1.2 8.8 0.1 3.7 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF937 PF06078.11 ORX69702.1 - 5.6 7.6 5.6 14 6.3 0.4 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) LSM PF01423.22 ORX69704.1 - 1.3e-18 66.4 0.0 1.6e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX69704.1 - 2e-05 24.6 0.0 3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain AIP3 PF03915.13 ORX69705.1 - 2.3e-51 175.2 12.1 2.3e-51 175.2 12.1 1.4 2 0 0 2 2 2 1 Actin interacting protein 3 CCDC-167 PF15188.6 ORX69705.1 - 1.9 8.9 11.4 36 4.8 0.1 3.1 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Cas_Csy4 PF09618.10 ORX69705.1 - 2.5 8.2 7.1 1.5 9.0 2.3 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) DUF1664 PF07889.12 ORX69705.1 - 3 7.9 10.4 0.7 9.9 0.1 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) SET PF00856.28 ORX69708.1 - 1.3e-05 25.7 0.0 2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 ORX69708.1 - 0.0022 18.7 0.2 0.0046 17.7 0.2 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Abhydrolase_1 PF00561.20 ORX69709.1 - 5.2e-23 82.0 0.2 2.6e-22 79.7 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX69709.1 - 1.1e-15 58.9 0.0 1.7e-15 58.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX69709.1 - 5.5e-10 38.9 0.0 3.8e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ndr PF03096.14 ORX69709.1 - 0.0016 17.2 0.0 0.0099 14.6 0.0 1.9 2 0 0 2 2 2 1 Ndr family Chlorophyllase PF07224.11 ORX69709.1 - 0.0063 15.6 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_4 PF08386.10 ORX69709.1 - 0.0094 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Chlorophyllase2 PF12740.7 ORX69709.1 - 0.016 14.2 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Galactosyl_T PF01762.21 ORX69710.1 - 0.003 17.4 0.7 0.062 13.1 0.6 2.1 2 0 0 2 2 2 2 Galactosyltransferase Peptidase_C13 PF01650.18 ORX69713.1 - 4.1e-42 144.5 0.4 4.9e-42 144.2 0.4 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 ORX69713.1 - 0.056 13.7 0.6 0.27 11.5 0.0 2.3 3 0 0 3 3 3 0 Mid domain of argonaute Sel1 PF08238.12 ORX69714.1 - 9.8e-08 32.4 4.5 0.049 14.3 0.2 4.7 5 1 0 5 5 5 2 Sel1 repeat TPR_1 PF00515.28 ORX69714.1 - 0.01 15.7 0.8 0.12 12.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX69714.1 - 0.065 13.4 0.1 0.065 13.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1036 PF06282.11 ORX69714.1 - 0.095 13.2 0.9 0.15 12.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1036) TPR_6 PF13174.6 ORX69714.1 - 0.11 13.1 3.2 5.4 7.9 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69714.1 - 1 9.8 3.4 1.7 9.1 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkr1 PF08636.10 ORX69717.1 - 8.4e-24 83.5 4.6 9.7e-24 83.3 4.6 1.0 1 0 0 1 1 1 1 ER protein Pkr1 DUF4083 PF13314.6 ORX69717.1 - 0.12 12.3 0.5 0.12 12.3 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4083) Sel1 PF08238.12 ORX69718.1 - 3.9e-36 122.7 32.2 1.6e-08 34.9 0.7 8.5 9 0 0 9 9 9 7 Sel1 repeat TPR_8 PF13181.6 ORX69718.1 - 0.73 10.2 10.0 7.1 7.1 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69718.1 - 5.2 6.8 10.9 2 8.2 0.2 4.6 6 0 0 6 6 6 0 TPR repeat Abhydrolase_1 PF00561.20 ORX69719.1 - 1.1e-26 94.0 0.5 4.7e-26 92.0 0.5 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX69719.1 - 8.9e-18 65.7 0.2 1.2e-17 65.2 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX69719.1 - 1.3e-09 37.7 0.0 2.1e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 ORX69719.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.7 ORX69719.1 - 0.038 12.9 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Ndr PF03096.14 ORX69719.1 - 0.041 12.6 0.0 0.11 11.2 0.0 1.6 2 0 0 2 2 2 0 Ndr family Phage_lysozyme PF00959.19 ORX69720.1 - 1.6e-13 51.0 0.0 2.5e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX69720.1 - 2.7e-05 24.3 0.3 2.7e-05 24.3 0.3 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain CHAP PF05257.16 ORX69721.1 - 1.2e-12 48.3 5.2 2.5e-12 47.2 5.2 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69721.1 - 0.00019 21.6 1.7 0.00023 21.4 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain PPR_2 PF13041.6 ORX69722.1 - 1.3e-18 66.9 0.1 2.1e-12 47.0 0.0 4.7 4 1 1 5 5 5 3 PPR repeat family PPR_3 PF13812.6 ORX69722.1 - 2.3e-10 40.4 0.2 2.6e-05 24.2 0.0 3.8 1 1 3 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.20 ORX69722.1 - 7.9e-10 38.3 2.5 4.6e-05 23.4 0.0 6.1 6 1 0 6 6 6 1 PPR repeat PPR_1 PF12854.7 ORX69722.1 - 3.9e-07 29.7 6.8 0.0098 15.6 0.0 5.6 6 0 0 6 6 6 1 PPR repeat PPR_long PF17177.4 ORX69722.1 - 1.1e-06 28.2 0.1 0.00019 20.9 0.0 2.5 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP RNA_pol_Rpb2_4 PF04566.13 ORX69722.1 - 0.13 12.6 0.1 0.45 10.8 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 4 COX16 PF14138.6 ORX69723.1 - 1.3e-20 73.7 0.0 2.2e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 LSM PF01423.22 ORX69724.1 - 3.2e-18 65.2 1.3 4.2e-18 64.8 1.3 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX69724.1 - 0.014 15.0 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Gemin7 PF11095.8 ORX69724.1 - 0.015 15.1 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.6 ORX69724.1 - 0.056 13.6 0.1 0.077 13.1 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF4897 PF16238.5 ORX69724.1 - 0.57 10.0 2.0 1.6 8.6 2.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4897) API5 PF05918.11 ORX69724.1 - 5.9 5.6 6.0 8.7 5.0 6.0 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DASH_Spc19 PF08287.11 ORX69725.1 - 5e-13 49.2 9.0 5e-13 49.2 9.0 2.4 2 1 1 3 3 3 1 Spc19 Fez1 PF06818.15 ORX69725.1 - 0.0077 16.7 15.0 0.28 11.6 11.6 2.8 1 1 1 2 2 2 2 Fez1 CENP-Q PF13094.6 ORX69725.1 - 0.95 9.7 18.3 2.9 8.1 15.6 2.8 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fib_alpha PF08702.10 ORX69725.1 - 2.9 8.1 15.0 9.5 6.4 2.3 3.4 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF2034 PF10356.9 ORX69726.1 - 5.8e-16 58.5 0.0 4.3e-09 36.1 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 ORX69726.1 - 4.1e-10 39.7 0.0 4.6e-10 39.5 0.0 1.0 1 0 0 1 1 1 1 Restriction endonuclease Mrr_cat_2 PF13156.6 ORX69726.1 - 0.13 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease SRP14 PF02290.15 ORX69727.1 - 2.8e-16 59.7 0.2 2.8e-16 59.7 0.2 2.2 1 1 1 2 2 2 1 Signal recognition particle 14kD protein Coq4 PF05019.13 ORX69728.1 - 6.3e-82 274.2 0.0 7.5e-82 273.9 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 TLD PF07534.16 ORX69729.1 - 5.8e-35 120.5 0.0 6.6e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 TLD Tti2 PF10521.9 ORX69730.1 - 2.8e-25 89.4 0.0 4.2e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Tti2 family EF-hand_7 PF13499.6 ORX69731.1 - 2.6e-23 82.3 5.0 1.3e-14 54.4 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX69731.1 - 2.8e-23 79.7 9.8 2e-08 33.2 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ORX69731.1 - 4.3e-23 80.9 6.8 1.5e-13 50.4 0.8 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ORX69731.1 - 9e-21 72.0 8.9 7.2e-08 31.8 0.3 4.8 4 2 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ORX69731.1 - 6.1e-12 44.5 15.4 7.8e-05 22.0 0.2 5.0 5 0 0 5 5 5 3 EF hand EF-hand_9 PF14658.6 ORX69731.1 - 9.4e-09 35.5 0.1 0.0022 18.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX69731.1 - 1.3e-06 28.3 2.4 0.0013 18.7 0.1 2.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 ORX69731.1 - 0.0017 18.3 1.5 0.058 13.3 0.1 2.9 1 1 1 3 3 3 1 Caleosin related protein Red1 PF07964.11 ORX69731.1 - 0.0071 14.6 0.6 0.0088 14.3 0.6 1.1 1 0 0 1 1 1 1 Rec10 / Red1 SPARC_Ca_bdg PF10591.9 ORX69731.1 - 0.01 16.2 0.8 1.5 9.1 0.1 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ORX69731.1 - 0.05 13.8 0.4 1.1 9.5 0.2 2.3 2 0 0 2 2 2 0 Dockerin type I domain MgtE_N PF03448.17 ORX69731.1 - 0.069 13.8 0.9 0.16 12.6 0.3 1.9 2 1 0 2 2 2 0 MgtE intracellular N domain B5 PF03484.15 ORX69731.1 - 0.078 13.3 1.2 13 6.1 0.1 2.7 1 1 1 2 2 2 0 tRNA synthetase B5 domain PhetRS_B1 PF18262.1 ORX69731.1 - 0.08 13.2 0.3 0.23 11.7 0.3 1.8 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain SurA_N_3 PF13624.6 ORX69731.1 - 0.21 11.4 2.7 2.5 7.9 0.4 2.1 1 1 1 2 2 2 0 SurA N-terminal domain Com_YlbF PF06133.11 ORX69731.1 - 0.26 11.9 3.4 0.86 10.2 0.4 3.0 2 2 2 4 4 4 0 Control of competence regulator ComK, YlbF/YmcA Acyltransferase PF01553.21 ORX69732.1 - 2.2e-22 79.1 0.0 3.5e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ORX69732.1 - 1.2e-13 51.0 0.1 2.5e-13 49.9 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus MAT1 PF06391.13 ORX69733.1 - 3.3e-48 164.2 25.4 4.1e-48 163.9 25.4 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 ORX69733.1 - 1.1e-22 79.7 10.1 2.1e-22 78.8 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX69733.1 - 7e-07 29.0 7.5 1.1e-06 28.4 7.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX69733.1 - 1.9e-05 24.5 9.5 0.00013 21.9 10.1 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX69733.1 - 4.5e-05 23.2 9.1 8.5e-05 22.4 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX69733.1 - 6.3e-05 23.2 9.1 0.0001 22.6 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ORX69733.1 - 0.00065 19.5 9.0 0.0071 16.2 9.7 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ORX69733.1 - 0.0017 18.2 10.7 0.0038 17.0 10.8 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX69733.1 - 0.015 15.3 6.1 0.032 14.2 3.6 2.3 1 1 1 2 2 2 0 RING-type zinc-finger GAGA PF09237.11 ORX69733.1 - 0.053 13.3 0.7 0.053 13.3 0.7 2.1 2 0 0 2 2 2 0 GAGA factor zf-RING_4 PF14570.6 ORX69733.1 - 0.11 12.3 9.0 1.7 8.5 9.9 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ORX69733.1 - 0.5 10.6 6.6 2.1 8.6 6.9 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Nop25 PF09805.9 ORX69733.1 - 0.66 10.4 17.2 0.081 13.4 10.2 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DZR PF12773.7 ORX69733.1 - 1.6 8.8 6.0 13 5.9 6.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ORX69733.1 - 2.6 8.2 8.0 16 5.7 3.8 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DUF3797 PF12677.7 ORX69733.1 - 4.1 7.4 7.4 0.46 10.4 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) WD40 PF00400.32 ORX69734.1 - 3.8e-13 49.7 0.3 1.3e-05 25.8 0.0 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX69734.1 - 1.9e-06 28.0 0.0 0.00036 20.8 0.0 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX69734.1 - 0.024 13.3 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 TrmE_N PF10396.9 ORX69734.1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 GTP-binding protein TrmE N-terminus Met_synt_B12 PF02965.17 ORX69735.1 - 1.5e-114 382.1 0.0 2.7e-114 381.3 0.0 1.5 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 ORX69735.1 - 1.8e-77 260.7 0.0 3.1e-77 260.0 0.0 1.4 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 ORX69735.1 - 1e-56 192.4 0.6 2.5e-56 191.1 0.6 1.7 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding_2 PF02607.17 ORX69735.1 - 4.4e-25 87.9 0.1 2.8e-24 85.3 0.0 2.5 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 ORX69735.1 - 2e-19 69.8 1.0 1.6e-18 66.9 0.4 2.7 2 0 0 2 2 2 1 B12 binding domain WXG100 PF06013.12 ORX69736.1 - 3.1e-07 30.5 1.1 4.8e-07 29.9 1.1 1.3 1 0 0 1 1 1 1 Proteins of 100 residues with WXG T7SS_ESX_EspC PF10824.8 ORX69736.1 - 0.00013 22.4 1.5 0.00019 21.8 1.5 1.2 1 0 0 1 1 1 1 Excreted virulence factor EspC, type VII ESX diderm DUF5082 PF16888.5 ORX69736.1 - 0.0031 17.8 0.2 0.0042 17.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) DivIVA PF05103.13 ORX69736.1 - 0.0042 17.2 0.4 0.005 16.9 0.4 1.1 1 0 0 1 1 1 1 DivIVA protein AI-2E_transport PF01594.16 ORX69736.1 - 0.011 14.9 2.0 0.015 14.4 2.0 1.1 1 0 0 1 1 1 0 AI-2E family transporter V-SNARE PF05008.15 ORX69736.1 - 0.024 15.0 0.4 0.042 14.2 0.4 1.4 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus TrbL PF04610.14 ORX69736.1 - 0.026 14.3 1.9 0.039 13.7 1.9 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein DUF3870 PF12986.7 ORX69736.1 - 0.05 13.8 0.2 0.068 13.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) Gypsy PF07253.11 ORX69736.1 - 0.054 12.0 0.6 0.061 11.9 0.6 1.1 1 0 0 1 1 1 0 Gypsy protein Na_K-ATPase PF00287.18 ORX69736.1 - 0.06 12.5 0.1 0.069 12.3 0.1 1.1 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain CorA PF01544.18 ORX69736.1 - 0.13 11.5 0.6 0.2 11.0 0.6 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein YlbD_coat PF14071.6 ORX69736.1 - 0.17 12.2 1.4 6.6 7.0 2.2 2.0 1 1 1 2 2 2 0 Putative coat protein HsbA PF12296.8 ORX69736.1 - 0.4 11.1 9.5 5 7.6 0.5 2.3 1 1 1 2 2 2 0 Hydrophobic surface binding protein A DASH_Duo1 PF08651.10 ORX69736.1 - 0.47 10.2 4.7 1 9.2 2.6 2.2 1 1 1 2 2 2 0 DASH complex subunit Duo1 Tape_meas_lam_C PF09718.10 ORX69736.1 - 3.6 7.8 7.7 0.23 11.6 1.4 2.2 2 1 1 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4510 PF14971.6 ORX69737.1 - 0.024 15.0 0.6 0.027 14.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) DUF4600 PF15372.6 ORX69737.1 - 0.029 14.8 0.0 0.031 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) DUF1505 PF07403.11 ORX69737.1 - 0.034 14.3 0.3 0.045 13.9 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1505) DUF3100 PF11299.8 ORX69737.1 - 0.14 11.6 2.8 0.22 10.9 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3100) Peptidase_S8 PF00082.22 ORX69738.1 - 1.4e-51 175.6 3.8 3.2e-51 174.4 3.8 1.6 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX69738.1 - 2.4e-09 37.1 1.0 8.5e-09 35.3 1.0 1.9 1 0 0 1 1 1 1 PA domain Inhibitor_I9 PF05922.16 ORX69738.1 - 0.00022 21.8 0.0 0.00067 20.3 0.0 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 fn3_5 PF06280.12 ORX69738.1 - 0.13 13.0 0.0 0.78 10.4 0.0 2.3 2 0 0 2 2 2 0 Fn3-like domain zf-C2H2 PF00096.26 ORX69742.1 - 1.9e-09 37.4 11.1 5.1e-06 26.6 1.4 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX69742.1 - 0.00026 21.6 9.8 0.019 15.8 0.8 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX69742.1 - 0.0023 18.3 1.1 0.0023 18.3 1.1 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_8 PF15909.5 ORX69742.1 - 0.011 16.1 2.5 2.2 8.6 0.1 2.6 1 1 1 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX69742.1 - 0.037 14.7 0.4 5.5 7.7 0.0 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain Ribosomal_L11 PF00298.19 ORX69743.1 - 1.2e-28 99.4 2.0 1.7e-28 98.9 2.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 ORX69743.1 - 4e-25 87.4 0.4 9.2e-25 86.3 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Sec1 PF00995.23 ORX69744.1 - 5.2e-117 392.5 0.1 6e-117 392.3 0.1 1.0 1 0 0 1 1 1 1 Sec1 family AsnA PF03590.15 ORX69744.1 - 0.025 14.3 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Aspartate-ammonia ligase DNA_pol_E_B PF04042.16 ORX69745.1 - 3.1e-39 134.5 0.9 6.7e-38 130.2 0.9 2.5 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 ORX69745.1 - 0.21 11.7 0.0 0.42 10.7 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain DnaJ PF00226.31 ORX69746.1 - 3.8e-21 75.0 2.5 7.1e-21 74.1 2.5 1.5 1 0 0 1 1 1 1 DnaJ domain AAA_11 PF13086.6 ORX69746.1 - 2.9 7.6 8.7 3.4 7.4 8.7 1.1 1 0 0 1 1 1 0 AAA domain Dynein_light PF01221.18 ORX69748.1 - 7e-33 112.8 0.2 7.7e-33 112.7 0.2 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ground-like PF04155.18 ORX69748.1 - 0.027 15.1 0.1 0.033 14.9 0.1 1.2 1 0 0 1 1 1 0 Ground-like domain TFIIS_C PF01096.18 ORX69749.1 - 2.4e-12 46.5 16.0 1.1e-11 44.4 7.4 3.2 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX69749.1 - 1.2e-11 44.2 4.1 1.2e-11 44.2 4.1 3.0 3 1 0 3 3 3 1 RNA polymerases M/15 Kd subunit zf-ACC PF17848.1 ORX69749.1 - 0.63 10.2 0.1 0.63 10.2 0.1 3.8 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain CpXC PF14353.6 ORX69749.1 - 3 7.9 13.6 1.2 9.2 0.6 2.7 2 1 1 3 3 3 0 CpXC protein PCMT PF01135.19 ORX69750.1 - 1.5e-72 243.8 0.0 1.7e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ORX69750.1 - 1.2e-06 29.1 0.0 3.6e-06 27.6 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX69750.1 - 1.6e-06 28.0 0.0 2.5e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX69750.1 - 0.00087 18.7 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 ORX69750.1 - 0.0009 19.3 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX69750.1 - 0.0013 19.4 0.0 0.0036 17.9 0.0 1.8 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX69750.1 - 0.0023 17.8 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX69750.1 - 0.0093 15.5 0.0 0.023 14.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ORX69750.1 - 0.022 14.7 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ORX69750.1 - 0.027 13.9 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 ORX69750.1 - 0.093 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase GCD14 PF08704.10 ORX69750.1 - 0.094 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Rrf2 PF02082.20 ORX69750.1 - 0.095 13.1 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator DOT1 PF08123.13 ORX69750.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Glycos_transf_2 PF00535.26 ORX69751.1 - 6.1e-35 120.5 0.0 7.3e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ORX69751.1 - 1.2e-13 51.5 0.0 1.5e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ORX69751.1 - 0.00018 21.1 0.0 0.00038 20.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 ORX69751.1 - 0.00027 20.5 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7N PF13733.6 ORX69751.1 - 0.032 13.9 0.2 0.15 11.7 0.0 1.9 2 0 0 2 2 2 0 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_4 PF13704.6 ORX69751.1 - 0.061 13.8 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 ER PF01133.17 ORX69752.1 - 2.8e-28 97.8 0.5 3.1e-28 97.7 0.5 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary NUC153 PF08159.12 ORX69753.1 - 1.1e-14 54.0 13.2 3.8e-14 52.2 1.7 3.8 3 0 0 3 3 3 3 NUC153 domain TB2_DP1_HVA22 PF03134.19 ORX69754.1 - 1.3e-20 73.1 0.6 3.1e-20 71.9 0.6 1.7 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF4746 PF15928.5 ORX69754.1 - 0.0021 17.5 6.9 0.0035 16.8 6.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) TRAP_alpha PF03896.16 ORX69754.1 - 0.018 14.3 0.5 0.026 13.7 0.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit XRN_N PF03159.18 ORX69754.1 - 0.69 9.3 4.0 1.1 8.7 4.0 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus CIA30 PF08547.12 ORX69755.1 - 3.8e-39 134.3 0.0 4.7e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) SGBP_B_XBD PF18329.1 ORX69755.1 - 0.0017 18.3 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 Surface glycan-binding protein B xyloglucan binding domain RRM_1 PF00076.22 ORX69756.1 - 1.8e-06 27.7 0.0 3.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX69756.1 - 0.054 13.5 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 ORX69758.1 - 9.1e-16 57.5 0.0 1.3e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ORX69758.1 - 6.5e-09 36.2 13.0 6.5e-09 36.2 13.0 1.7 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 SAM_4 PF18017.1 ORX69759.1 - 0.03 14.3 2.4 40 4.3 0.0 5.6 7 0 0 7 7 7 0 SAM domain (Sterile alpha motif) Glyco_transf_20 PF00982.21 ORX69760.1 - 1.6e-157 525.0 0.0 2.2e-157 524.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX69760.1 - 1.1e-68 230.8 0.0 3e-68 229.5 0.0 1.7 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ORX69760.1 - 0.0056 16.5 0.0 0.16 11.7 0.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Glyco_transf_5 PF08323.11 ORX69760.1 - 0.036 13.8 0.1 0.079 12.6 0.1 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain Snf7 PF03357.21 ORX69761.1 - 8.1e-41 139.5 17.4 9.1e-41 139.3 17.4 1.0 1 0 0 1 1 1 1 Snf7 DUF745 PF05335.13 ORX69761.1 - 0.034 13.9 7.2 0.058 13.1 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF1319 PF07028.11 ORX69761.1 - 0.055 13.7 3.6 0.25 11.6 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) NPV_P10 PF05531.12 ORX69761.1 - 0.17 12.3 4.9 2.2 8.8 1.2 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.17 ORX69761.1 - 0.21 11.5 8.8 0.86 9.5 0.0 3.2 2 1 1 3 3 3 0 Prefoldin subunit DUF2890 PF11081.8 ORX69761.1 - 0.24 11.5 4.0 1.5 8.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Metalloenzyme PF01676.18 ORX69761.1 - 0.25 10.7 1.6 0.61 9.4 1.6 1.7 1 1 0 1 1 1 0 Metalloenzyme superfamily FlaC_arch PF05377.11 ORX69761.1 - 1 9.8 0.1 1 9.8 0.1 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 ORX69761.1 - 3.1 8.5 10.6 14 6.4 0.0 3.2 2 1 1 3 3 3 0 SlyX CNOT11 PF10155.9 ORX69762.1 - 1.3e-06 28.6 0.0 1.8e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 ABC1 PF03109.16 ORX69763.1 - 9.4e-30 103.2 0.0 1.7e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 ORX69763.1 - 0.032 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Ank_5 PF13857.6 ORX69764.1 - 7.7e-10 38.8 0.0 1.5e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX69764.1 - 1.3e-08 35.3 0.0 3.1e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX69764.1 - 6.2e-08 32.8 0.0 1.1e-06 28.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ORX69764.1 - 1.9e-06 28.3 0.2 1e-05 26.0 0.1 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX69764.1 - 1.9e-06 27.7 0.0 1.3e-05 25.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Rubredoxin_C PF18267.1 ORX69764.1 - 0.043 13.7 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Rubredoxin NAD+ reductase C-terminal domain zf-C2H2 PF00096.26 ORX69767.1 - 2.2e-07 30.9 7.4 3.7e-05 23.9 1.5 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX69767.1 - 3e-07 30.6 3.3 3e-07 30.6 3.3 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX69767.1 - 0.00025 21.6 6.5 0.0061 17.3 1.1 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX69767.1 - 0.0038 17.2 2.3 1.7 8.8 0.3 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX69767.1 - 0.0051 17.1 0.3 0.047 14.0 0.4 1.8 1 1 0 1 1 1 1 C2H2-type zinc ribbon CHORD PF04968.12 ORX69767.1 - 0.012 16.3 1.6 0.026 15.3 1.6 1.6 1 1 0 1 1 1 0 CHORD FOXP-CC PF16159.5 ORX69767.1 - 0.019 15.6 3.0 0.079 13.6 0.4 2.1 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_3rep PF18868.1 ORX69767.1 - 0.033 14.9 0.4 0.15 12.7 0.0 1.8 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF1168 PF06658.12 ORX69768.1 - 1.7e-34 118.5 9.2 1.7e-34 118.5 9.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) Presenilin PF01080.17 ORX69768.1 - 4.5 5.9 5.5 4.4 6.0 5.5 1.1 1 0 0 1 1 1 0 Presenilin HHV-5_US34A PF17087.5 ORX69768.1 - 6.4 7.0 6.5 15 5.8 6.5 1.6 1 0 0 1 1 1 0 Herpesvirus US34A protein family SURF6 PF04935.12 ORX69769.1 - 3.2e-31 108.7 50.9 3.2e-31 108.7 50.9 2.3 1 1 1 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 ORX69769.1 - 3.4e-18 66.0 3.8 3.4e-18 66.0 3.8 6.1 5 2 0 5 5 5 1 60S ribosome biogenesis protein Rrp14 SIR2 PF02146.17 ORX69770.1 - 1e-34 120.0 0.1 2e-34 119.0 0.1 1.5 1 0 0 1 1 1 1 Sir2 family Snapin_Pallidin PF14712.6 ORX69771.1 - 1.3e-07 31.9 0.1 3.7e-07 30.5 0.1 1.7 2 0 0 2 2 2 1 Snapin/Pallidin DivIC PF04977.15 ORX69771.1 - 0.71 9.7 5.1 0.22 11.3 1.1 1.9 1 1 1 2 2 2 0 Septum formation initiator DUF2721 PF11026.8 ORX69771.1 - 2.6 8.0 4.1 1.3 8.9 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) AA_permease PF00324.21 ORX69772.1 - 3.6e-111 372.1 40.7 6.5e-110 368.0 40.7 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX69772.1 - 2e-42 145.6 39.9 3.5e-37 128.2 26.3 2.0 1 1 1 2 2 2 2 Amino acid permease Pkinase PF00069.25 ORX69773.1 - 2.4e-61 207.4 0.0 1e-41 143.0 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69773.1 - 1.4e-24 86.8 0.2 3.9e-13 49.3 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX69773.1 - 0.00018 20.9 0.1 0.0064 15.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX69773.1 - 0.012 14.5 0.0 1.6 7.6 0.0 2.0 1 1 1 2 2 2 0 Haspin like kinase domain APH PF01636.23 ORX69773.1 - 0.036 14.0 1.5 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family EFP_N PF08207.12 ORX69773.1 - 0.089 12.8 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain DUF2015 PF09435.10 ORX69773.1 - 0.16 11.8 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) Cation_efflux PF01545.21 ORX69774.1 - 4.8e-47 160.3 6.8 5.6e-47 160.1 6.8 1.0 1 0 0 1 1 1 1 Cation efflux family Svf1_C PF17187.4 ORX69775.1 - 7.7e-24 84.4 0.0 1.2e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 ORX69775.1 - 2.1e-12 47.4 0.4 3.1e-12 46.8 0.4 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Lipase_3 PF01764.25 ORX69776.1 - 8.3e-14 51.7 0.0 4.8e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) DUF5427 PF10310.9 ORX69776.1 - 0.24 10.3 4.1 10 4.9 4.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF3730 PF12530.8 ORX69778.1 - 0.00013 21.6 1.6 0.00026 20.6 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3730) Acetyltransf_1 PF00583.25 ORX69779.1 - 8.1e-11 42.2 0.1 9.2e-11 42.0 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX69779.1 - 1e-05 25.9 0.1 1.3e-05 25.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX69779.1 - 0.00041 20.3 0.1 0.00049 20.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Yippee-Mis18 PF03226.14 ORX69780.1 - 4.8e-13 49.2 0.1 5.7e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 ORX69780.1 - 0.00058 20.1 0.3 0.0007 19.8 0.3 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I zinc_ribbon_10 PF10058.9 ORX69780.1 - 0.0023 17.6 0.3 0.12 12.1 0.0 2.3 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF4453 PF14627.6 ORX69780.1 - 0.079 13.1 0.0 0.098 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) Med1 PF10744.9 ORX69781.1 - 1.6e-23 83.4 2.5 4.6e-13 49.0 0.7 2.2 2 0 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 TPR_2 PF07719.17 ORX69782.1 - 4.4e-28 95.1 3.6 3.3e-06 26.8 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69782.1 - 5.3e-26 89.3 0.1 2.9e-07 30.0 0.1 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69782.1 - 5.2e-19 66.8 0.0 0.00051 20.0 0.0 6.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69782.1 - 1.4e-15 56.6 12.3 0.011 16.5 0.1 7.4 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69782.1 - 2.2e-15 57.0 7.2 3e-06 27.8 0.2 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69782.1 - 7.4e-15 55.0 14.6 0.00012 22.3 1.7 6.1 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69782.1 - 7.9e-13 48.7 1.7 0.0003 21.2 0.0 5.0 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69782.1 - 1.2e-11 44.1 1.3 0.0059 16.3 0.0 6.1 4 2 3 7 7 7 3 TPR repeat TPR_7 PF13176.6 ORX69782.1 - 5.1e-11 41.8 7.4 0.00069 19.5 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX69782.1 - 3.4e-08 33.6 4.3 0.077 13.2 0.2 4.6 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ORX69782.1 - 3.5e-08 33.3 4.4 0.072 13.5 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX69782.1 - 2.7e-06 27.4 9.6 0.00039 20.5 1.3 4.5 3 2 2 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX69782.1 - 1.2e-05 25.1 13.8 0.46 10.4 0.6 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX69782.1 - 0.0028 16.9 3.2 0.007 15.6 2.0 2.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX69782.1 - 0.0031 18.0 12.4 5.8 7.8 0.1 6.1 5 2 2 7 7 6 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX69782.1 - 0.0057 15.6 0.3 0.46 9.3 0.0 2.8 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 DUF3808 PF10300.9 ORX69782.1 - 0.061 12.1 0.1 1.6 7.4 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3808) TPR_4 PF07721.14 ORX69782.1 - 0.16 12.7 12.0 3.2 8.6 0.0 5.4 6 1 1 7 7 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX69782.1 - 1.9 8.6 4.7 1.9 8.7 0.0 3.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 ORX69782.1 - 1.9 8.0 5.4 2.8 7.5 0.0 3.8 5 0 0 5 5 5 0 SHNi-TPR BTAD PF03704.17 ORX69782.1 - 2 8.9 8.2 4 7.9 0.8 3.6 2 2 0 2 2 2 0 Bacterial transcriptional activator domain Glyco_hydro_61 PF03443.14 ORX69783.1 - 3.5e-20 72.8 0.6 3.9e-20 72.7 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 EF1G PF00647.19 ORX69788.1 - 3.4e-45 152.5 0.6 5.6e-45 151.8 0.6 1.3 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 ORX69788.1 - 3.2e-11 43.3 0.0 3.2e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX69788.1 - 3.8e-11 43.2 0.0 1.4e-10 41.4 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX69788.1 - 1.3e-07 31.5 0.0 3.2e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX69788.1 - 1.6e-07 31.6 0.0 5.3e-07 29.9 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX69788.1 - 2.1e-07 31.1 0.0 7.2e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX69788.1 - 0.0025 18.1 0.0 0.0055 17.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ORX69788.1 - 0.061 13.1 0.0 0.18 11.6 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sugar_tr PF00083.24 ORX69789.1 - 2.3e-120 402.5 21.8 2.6e-120 402.4 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX69789.1 - 9.8e-31 106.9 46.8 9.4e-24 84.0 22.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 ORX69789.1 - 0.5 10.2 3.2 0.6 9.9 0.0 2.6 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Tam41_Mmp37 PF09139.11 ORX69790.1 - 3.8e-109 365.0 0.1 8.2e-109 363.9 0.0 1.5 2 0 0 2 2 2 1 Phosphatidate cytidylyltransferase, mitochondrial SR-25 PF10500.9 ORX69790.1 - 0.021 14.4 5.5 0.033 13.8 5.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SDA1 PF05285.12 ORX69790.1 - 0.057 12.8 3.0 0.072 12.5 2.3 1.4 2 0 0 2 2 2 0 SDA1 EMP70 PF02990.16 ORX69791.1 - 2.6e-177 590.6 1.8 3.7e-177 590.1 1.8 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 ATP1G1_PLM_MAT8 PF02038.16 ORX69791.1 - 0.071 12.6 0.6 0.21 11.0 0.6 1.8 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Abhydrolase_1 PF00561.20 ORX69792.1 - 1.3e-17 64.3 0.0 2.5e-11 43.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX69792.1 - 6.7e-13 49.7 0.1 1.6e-12 48.5 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX69792.1 - 1.8e-05 24.2 0.0 0.00021 20.6 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ORX69792.1 - 4.8e-05 23.4 0.0 8.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Glyco_hydro_61 PF03443.14 ORX69793.1 - 2.5e-19 70.1 0.2 2.7e-19 69.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 zf-C2H2_2 PF12756.7 ORX69795.1 - 2.7e-06 27.7 5.7 0.0079 16.5 3.6 4.5 2 2 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Spc24 PF08286.11 ORX69796.1 - 2.5e-06 27.7 0.7 2.5e-06 27.7 0.7 3.0 1 1 2 3 3 3 1 Spc24 subunit of Ndc80 TMF_DNA_bd PF12329.8 ORX69796.1 - 0.00045 20.2 19.0 0.0031 17.5 6.3 2.8 1 1 0 2 2 2 1 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.12 ORX69796.1 - 0.0021 18.1 23.9 0.0052 16.8 4.5 2.9 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.7 ORX69796.1 - 0.0093 16.1 9.2 0.0093 16.1 9.2 2.5 1 1 1 2 2 2 1 Tropomyosin like DivIC PF04977.15 ORX69796.1 - 0.018 14.8 20.8 0.27 11.0 2.1 3.6 1 1 2 4 4 4 0 Septum formation initiator HrcA_DNA-bdg PF03444.15 ORX69796.1 - 0.033 13.8 0.8 6.4 6.5 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF2730 PF10805.8 ORX69796.1 - 0.037 14.1 10.6 0.066 13.3 3.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) bZIP_2 PF07716.15 ORX69796.1 - 0.047 13.8 13.7 0.86 9.7 3.6 3.4 2 1 1 3 3 3 0 Basic region leucine zipper ADIP PF11559.8 ORX69796.1 - 0.05 13.7 24.2 0.13 12.3 9.0 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 ORX69796.1 - 0.092 12.7 17.1 0.98 9.4 3.5 3.4 1 1 2 3 3 3 0 Prefoldin subunit SlyX PF04102.12 ORX69796.1 - 0.11 13.1 24.7 0.69 10.6 3.5 3.6 2 1 2 4 4 3 0 SlyX Exonuc_VII_L PF02601.15 ORX69796.1 - 0.12 11.9 10.4 0.15 11.6 10.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit GAS PF13851.6 ORX69796.1 - 0.14 11.5 20.1 0.39 10.0 13.3 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding MIP-T3_C PF17749.1 ORX69796.1 - 0.18 11.8 17.9 1.1e+02 2.7 17.9 2.2 1 1 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region T7SS_ESX_EspC PF10824.8 ORX69796.1 - 0.2 12.2 5.4 0.17 12.4 1.5 2.5 1 1 1 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm Prominin PF05478.11 ORX69796.1 - 0.24 9.3 9.2 0.31 9.0 9.2 1.1 1 0 0 1 1 1 0 Prominin ZapB PF06005.12 ORX69796.1 - 0.31 11.5 22.3 1.2 9.7 5.2 3.1 1 1 2 3 3 3 0 Cell division protein ZapB ATP-synt_D PF01813.17 ORX69796.1 - 0.31 10.8 12.1 0.24 11.2 1.2 2.2 1 1 1 2 2 2 0 ATP synthase subunit D APG6_N PF17675.1 ORX69796.1 - 0.34 11.5 24.8 0.37 11.3 16.1 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region NPV_P10 PF05531.12 ORX69796.1 - 0.38 11.2 11.0 5 7.7 0.3 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RasGAP_C PF03836.15 ORX69796.1 - 0.39 10.9 14.0 1.5 9.0 2.1 3.0 1 1 1 2 2 2 0 RasGAP C-terminus Snapin_Pallidin PF14712.6 ORX69796.1 - 0.41 11.1 13.6 0.68 10.4 4.9 2.4 2 0 0 2 2 2 0 Snapin/Pallidin OmpH PF03938.14 ORX69796.1 - 0.45 10.8 21.8 7.6 6.9 21.9 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4795 PF16043.5 ORX69796.1 - 0.53 9.9 19.9 2.1 7.9 19.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DASH_Spc19 PF08287.11 ORX69796.1 - 0.54 10.1 18.6 0.34 10.8 3.3 2.9 1 1 1 2 2 2 0 Spc19 Spc7 PF08317.11 ORX69796.1 - 0.54 9.1 22.0 4.5 6.1 22.0 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein PRKG1_interact PF15898.5 ORX69796.1 - 0.58 11.1 19.3 0.47 11.4 12.4 2.4 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4140 PF13600.6 ORX69796.1 - 0.61 10.6 20.3 2.5 8.6 5.8 3.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Seryl_tRNA_N PF02403.22 ORX69796.1 - 0.65 10.2 17.9 2.1 8.6 5.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 ORX69796.1 - 0.66 9.3 19.3 2.4 7.4 5.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Swi5 PF07061.11 ORX69796.1 - 0.71 10.0 14.1 7.7 6.7 0.3 3.4 2 1 1 3 3 3 0 Swi5 Apolipoprotein PF01442.18 ORX69796.1 - 0.76 9.6 22.7 1.7 8.4 8.6 2.2 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain zf-C4H2 PF10146.9 ORX69796.1 - 0.79 10.0 14.0 0.42 10.9 10.0 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein EzrA PF06160.12 ORX69796.1 - 1.1 7.4 15.2 0.47 8.6 9.2 1.9 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Ax_dynein_light PF10211.9 ORX69796.1 - 1.1 9.2 19.1 3.2 7.6 3.4 2.5 1 1 1 2 2 2 0 Axonemal dynein light chain DUF3618 PF12277.8 ORX69796.1 - 1.1 9.5 8.4 8.4 6.7 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3618) FapA PF03961.13 ORX69796.1 - 1.2 7.7 12.4 0.37 9.3 7.4 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4763 PF15960.5 ORX69796.1 - 1.2 8.4 16.3 2.2 7.5 16.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) DUF2353 PF09789.9 ORX69796.1 - 1.2 8.4 17.1 6.8 6.0 17.1 1.9 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) FUSC PF04632.12 ORX69796.1 - 1.3 7.5 7.7 1.8 7.0 7.7 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Vps51 PF08700.11 ORX69796.1 - 1.3 9.2 12.6 1 9.5 1.2 2.8 2 1 0 2 2 2 0 Vps51/Vps67 PilJ PF13675.6 ORX69796.1 - 1.4 8.9 13.2 4.4 7.4 5.5 2.5 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4618 PF15397.6 ORX69796.1 - 1.5 8.2 17.4 0.29 10.5 11.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DUF1664 PF07889.12 ORX69796.1 - 1.6 8.8 13.5 2.8 8.0 6.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PriC PF07445.12 ORX69796.1 - 1.6 8.6 18.4 3.8 7.4 18.4 1.6 1 1 0 1 1 1 0 Primosomal replication protein priC Syntaxin-6_N PF09177.11 ORX69796.1 - 1.7 9.2 10.8 24 5.5 10.3 2.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF1917 PF08939.10 ORX69796.1 - 1.7 8.5 7.8 2.1 8.2 6.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1917) CC2-LZ PF16516.5 ORX69796.1 - 1.7 9.0 16.6 4.6 7.7 3.6 3.1 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Fez1 PF06818.15 ORX69796.1 - 1.9 8.9 19.0 2.8 8.3 19.0 1.2 1 0 0 1 1 1 0 Fez1 Prefoldin PF02996.17 ORX69796.1 - 2 8.3 17.2 4.2 7.3 1.5 3.6 1 1 1 4 4 4 0 Prefoldin subunit DUF5082 PF16888.5 ORX69796.1 - 2.1 8.7 19.8 11 6.4 1.2 3.3 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF3450 PF11932.8 ORX69796.1 - 2.3 7.5 23.2 0.68 9.2 13.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF3086 PF11285.8 ORX69796.1 - 2.4 7.2 15.3 0.79 8.8 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) Uds1 PF15456.6 ORX69796.1 - 2.4 8.3 17.0 41 4.3 17.0 2.5 1 1 0 1 1 1 0 Up-regulated During Septation DUF948 PF06103.11 ORX69796.1 - 2.6 8.4 7.2 9.5 6.6 0.2 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TRAF_BIRC3_bd PF16673.5 ORX69796.1 - 2.6 7.9 11.1 7.3 6.5 0.5 3.5 2 1 2 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain DUF2205 PF10224.9 ORX69796.1 - 2.9 8.0 18.4 0.35 10.9 1.4 3.5 1 1 2 3 3 3 0 Short coiled-coil protein DASH_Dam1 PF08653.10 ORX69796.1 - 3.1 7.7 6.2 19 5.2 0.2 3.2 3 1 0 3 3 3 0 DASH complex subunit Dam1 XhlA PF10779.9 ORX69796.1 - 3.3 8.0 12.1 1.2 9.4 1.7 3.7 3 1 1 4 4 3 0 Haemolysin XhlA JIP_LZII PF16471.5 ORX69796.1 - 3.5 7.9 15.7 20 5.4 3.1 3.2 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.9 ORX69796.1 - 3.5 7.8 23.0 11 6.2 14.6 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DHR10 PF18595.1 ORX69796.1 - 4.3 7.4 26.4 2.9 8.0 6.6 3.1 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain AAA_13 PF13166.6 ORX69796.1 - 4.6 5.8 15.4 8.5 4.9 15.4 1.3 1 1 0 1 1 1 0 AAA domain HALZ PF02183.18 ORX69796.1 - 4.6 7.5 8.6 28 5.0 0.1 3.6 3 1 0 3 3 3 0 Homeobox associated leucine zipper DUF4446 PF14584.6 ORX69796.1 - 4.8 7.1 10.9 2.7 8.0 2.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) BST2 PF16716.5 ORX69796.1 - 5.1 7.7 19.7 0.7 10.5 10.1 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Nup54 PF13874.6 ORX69796.1 - 5.4 7.1 19.4 0.42 10.7 0.7 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 CorA PF01544.18 ORX69796.1 - 5.8 6.1 14.2 45 3.2 14.1 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 ORX69796.1 - 6 6.9 11.9 2.3e+02 1.8 11.9 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.14 ORX69796.1 - 6.5 6.5 13.6 0.77 9.5 0.1 3.0 1 1 1 2 2 1 0 Hepatic lectin, N-terminal domain V_ATPase_I PF01496.19 ORX69796.1 - 6.5 4.5 12.0 1.6 6.5 8.4 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family YabA PF06156.13 ORX69796.1 - 6.9 7.4 14.2 2.8e+03 -1.0 14.2 2.5 1 1 0 1 1 0 0 Initiation control protein YabA FlaC_arch PF05377.11 ORX69796.1 - 7.1 7.1 11.1 34 4.9 0.1 3.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF812 PF05667.11 ORX69796.1 - 9.4 5.0 20.2 20 3.9 20.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Creatinase_N_2 PF16189.5 ORX69797.1 - 1.1e-53 181.7 0.0 3e-53 180.2 0.0 1.8 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ORX69797.1 - 2.4e-42 145.0 0.0 3.4e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ORX69797.1 - 1.7e-25 88.9 0.0 4.9e-25 87.4 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ORX69797.1 - 7.6e-21 75.1 0.0 2.7e-15 57.2 0.0 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Evr1_Alr PF04777.13 ORX69798.1 - 2.6e-26 92.0 0.8 3e-26 91.8 0.8 1.1 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC4 PF18775.1 ORX69798.1 - 0.0062 16.7 0.2 0.011 15.9 0.2 1.6 1 1 0 1 1 1 1 APOBEC4 Pox_E10 PF04805.12 ORX69798.1 - 0.026 14.4 0.0 0.037 13.9 0.0 1.3 1 1 0 1 1 1 0 E10-like protein conserved region APOBEC1 PF18769.1 ORX69798.1 - 0.11 12.8 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 APOBEC1 Zn_ribbon_recom PF13408.6 ORX69798.1 - 0.14 12.7 2.2 0.93 10.1 2.2 2.0 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain FAD_SOX PF18371.1 ORX69798.1 - 0.14 12.5 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase DUF4097 PF13349.6 ORX69799.1 - 4.1e-08 32.9 0.1 2.5e-07 30.3 0.0 2.2 2 1 0 2 2 2 1 Putative adhesin Glyco_hyd_65N_2 PF14498.6 ORX69799.1 - 0.16 11.8 1.0 0.37 10.6 0.9 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF4097 PF13349.6 ORX69800.1 - 7.4e-16 58.2 0.8 1.3e-09 37.7 2.8 2.1 1 1 1 2 2 2 2 Putative adhesin DUF4097 PF13349.6 ORX69801.1 - 3.8e-13 49.4 17.3 8.6e-07 28.6 3.3 2.2 1 1 1 2 2 2 2 Putative adhesin Tyrosinase PF00264.20 ORX69802.1 - 1.4e-25 91.0 11.6 3.8e-25 89.5 7.5 2.8 2 1 0 2 2 2 1 Common central domain of tyrosinase Tape_meas_lam_C PF09718.10 ORX69802.1 - 0.031 14.4 0.0 2 8.6 0.0 2.5 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4611 PF15387.6 ORX69802.1 - 1.1 9.6 3.7 42 4.5 2.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Tyrosinase PF00264.20 ORX69803.1 - 7.2e-29 101.7 9.8 1.5e-27 97.3 9.8 2.3 1 1 0 1 1 1 1 Common central domain of tyrosinase Tyrosinase PF00264.20 ORX69804.1 - 2.4e-21 77.1 9.1 2.7e-15 57.3 2.1 2.4 1 1 1 2 2 2 2 Common central domain of tyrosinase RasGEF PF00617.19 ORX69855.1 - 6.5e-14 52.5 0.0 1.2e-07 32.1 0.0 4.0 3 0 0 3 3 3 3 RasGEF domain PH_9 PF15410.6 ORX69855.1 - 2.8e-09 37.4 0.0 7.2e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX69855.1 - 1.5e-08 35.1 0.0 3.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 PH domain RasGEF_N PF00618.20 ORX69855.1 - 0.017 15.3 0.1 0.8 10.0 0.0 3.1 3 0 0 3 3 3 0 RasGEF N-terminal motif DUF21 PF01595.20 ORX69856.1 - 7.1e-39 133.3 0.1 7.1e-39 133.3 0.1 1.5 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ORX69856.1 - 5.7e-05 23.5 6.5 0.031 14.7 1.1 3.6 3 0 0 3 3 3 2 CBS domain Diphthamide_syn PF01866.17 ORX69857.1 - 7.5e-122 406.5 0.0 8.5e-122 406.3 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein LPMO_10 PF03067.15 ORX69858.1 - 3e-05 24.8 0.0 4.1e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX69858.1 - 0.04 13.8 0.0 0.068 13.1 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 61 ACPS PF01648.20 ORX69859.1 - 5.5e-11 42.6 0.0 2.1e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Glyco_hydro_19 PF00182.19 ORX69860.1 - 2e-12 47.5 3.1 5.7e-10 39.5 3.1 2.3 1 1 0 1 1 1 1 Chitinase class I Arm PF00514.23 ORX69861.1 - 7.2e-17 60.8 10.9 3.7e-05 23.6 0.0 8.7 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX69861.1 - 3.4e-10 40.2 4.5 4.9e-05 23.7 0.1 5.1 6 0 0 6 6 6 3 HEAT-like repeat RICTOR_V PF14668.6 ORX69861.1 - 2.9e-07 30.6 0.1 0.012 15.8 0.0 3.9 3 1 0 3 3 3 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.6 ORX69861.1 - 4.3e-07 30.2 4.1 0.48 10.9 0.1 5.6 3 2 3 6 6 6 4 HEAT repeats IBB PF01749.20 ORX69861.1 - 0.00049 20.5 1.8 0.002 18.6 1.8 2.1 1 0 0 1 1 1 1 Importin beta binding domain Neurochondrin PF05536.11 ORX69861.1 - 0.0061 15.0 0.2 0.024 13.0 0.0 2.0 2 1 1 3 3 3 1 Neurochondrin Cob_adeno_trans PF01923.18 ORX69862.1 - 1.8e-54 184.3 0.0 2.4e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Transferase PF02458.15 ORX69863.1 - 6.7e-18 64.6 0.0 3.1e-14 52.5 0.0 2.3 2 1 0 2 2 2 2 Transferase family ALO PF04030.14 ORX69866.1 - 2.6e-84 283.1 6.7 3.3e-84 282.8 6.7 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ORX69866.1 - 8.9e-29 100.0 0.0 1.5e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NCBP3 PF10309.9 ORX69866.1 - 0.019 14.8 0.1 0.045 13.6 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 Exo_endo_phos PF03372.23 ORX69867.1 - 4.3e-16 59.1 0.0 5.8e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX69867.1 - 0.025 14.4 0.1 0.16 11.8 0.0 2.3 3 0 0 3 3 3 0 Endonuclease-reverse transcriptase TERB2 PF15101.6 ORX69869.1 - 7.3e-11 42.5 0.2 9.2e-11 42.2 0.2 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Vps51 PF08700.11 ORX69870.1 - 7.5e-25 86.8 0.9 8.2e-25 86.7 0.9 1.0 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ORX69870.1 - 4.1e-05 23.7 0.2 4.8e-05 23.4 0.2 1.0 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Dor1 PF04124.12 ORX69870.1 - 6e-05 21.9 0.1 6.8e-05 21.7 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 ORX69870.1 - 0.0032 17.6 0.1 0.0039 17.4 0.1 1.1 1 0 0 1 1 1 1 Golgi transport complex subunit 5 DUF948 PF06103.11 ORX69870.1 - 0.082 13.2 0.6 0.27 11.5 0.2 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Img2 PF05046.14 ORX69870.1 - 0.12 12.6 0.2 0.37 11.1 0.2 1.9 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) ORC5_C PF14630.6 ORX69872.1 - 5.6e-69 232.8 0.1 6.9e-69 232.5 0.1 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 ORX69872.1 - 1.9e-17 64.2 0.0 3.9e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX69872.1 - 7.4e-10 39.2 0.0 1.6e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX69872.1 - 0.0026 18.2 0.0 0.0054 17.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ORX69872.1 - 0.0027 17.2 0.0 0.0044 16.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_7 PF12775.7 ORX69872.1 - 0.0073 15.8 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 ORX69872.1 - 0.033 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 ORX69872.1 - 0.033 14.3 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ORX69872.1 - 0.044 13.7 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 ORX69872.1 - 0.065 13.8 0.0 0.12 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX69872.1 - 0.09 12.8 0.0 0.41 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ORX69872.1 - 0.13 11.5 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 ORX69872.1 - 0.18 11.0 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 ORX69872.1 - 0.19 11.4 0.0 0.37 10.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_pol_Rpb5_C PF01191.19 ORX69873.1 - 1.7e-34 117.5 0.1 3.8e-34 116.4 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 ORX69873.1 - 2.1e-30 105.1 0.1 3.7e-30 104.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 ORX69873.1 - 0.0062 16.5 0.0 0.03 14.3 0.0 2.1 2 1 0 2 2 2 1 Restriction endonuclease SHS2_Rpb7-N PF03876.17 ORX69873.1 - 0.12 12.7 0.0 1 9.8 0.0 2.3 2 0 0 2 2 2 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 MMS1_N PF10433.9 ORX69874.1 - 1.8e-134 449.0 0.0 2.5e-134 448.6 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX69874.1 - 9.1e-73 245.4 0.0 1.9e-72 244.3 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 ORX69874.1 - 0.017 15.4 0.1 2.9 8.3 0.0 3.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX69874.1 - 0.021 15.7 0.0 6.7 7.8 0.0 3.9 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF1797 PF08796.10 ORX69874.1 - 0.092 12.8 0.3 0.37 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) Ribosomal_L22 PF00237.19 ORX69875.1 - 6.8e-24 84.1 0.1 1e-23 83.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e hDGE_amylase PF14701.6 ORX69876.1 - 1.9e-151 505.1 0.0 2.6e-151 504.7 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 ORX69876.1 - 4.8e-119 397.7 0.0 6.7e-119 397.2 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 ORX69876.1 - 2e-72 243.9 0.0 3.2e-72 243.2 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 ORX69876.1 - 1.1e-16 60.8 0.1 2.1e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme RNA_pol_Rpb4 PF03874.16 ORX69877.1 - 2.2e-21 76.5 1.7 5.5e-21 75.2 1.7 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 FUSC_2 PF13515.6 ORX69878.1 - 6.1e-12 45.8 14.1 6.1e-12 45.8 14.1 2.9 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 ORX69878.1 - 5.5e-10 38.7 5.6 5.5e-10 38.7 5.6 2.2 2 0 0 2 2 2 1 Aluminium activated malate transporter ArAE_2_N PF10337.9 ORX69878.1 - 3.4e-07 29.7 0.5 3.4e-07 29.7 0.5 3.5 3 1 1 4 4 4 2 Putative ER transporter, 6TM, N-terminal Caveolin PF01146.17 ORX69878.1 - 0.87 9.5 4.8 0.25 11.3 0.7 2.3 2 0 0 2 2 2 0 Caveolin ABC_tran PF00005.27 ORX69879.1 - 3e-53 180.0 0.0 5.3e-28 98.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX69879.1 - 4.9e-48 164.1 27.6 4.4e-31 108.5 13.4 2.8 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX69879.1 - 3.2e-11 43.1 0.3 0.00099 18.6 0.0 3.9 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX69879.1 - 5.8e-08 32.9 2.7 0.026 14.3 0.3 4.2 2 2 2 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 ORX69879.1 - 6.3e-06 26.3 0.2 0.19 11.8 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase T2SSE PF00437.20 ORX69879.1 - 6.3e-06 25.4 0.2 0.035 13.2 0.2 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.6 ORX69879.1 - 1.2e-05 25.9 1.2 0.00029 21.4 0.2 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX69879.1 - 1.4e-05 24.8 1.7 0.0046 16.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX69879.1 - 0.00012 22.4 0.3 0.37 11.1 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ORX69879.1 - 0.00033 20.3 0.7 0.0093 15.6 0.1 2.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX69879.1 - 0.00035 20.5 1.6 0.04 13.8 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ORX69879.1 - 0.00077 19.9 3.3 1 9.7 0.6 3.0 2 2 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 ORX69879.1 - 0.0012 18.9 0.2 0.18 11.9 0.0 2.4 2 0 0 2 2 2 1 Dynamin family Zeta_toxin PF06414.12 ORX69879.1 - 0.0014 18.0 0.4 0.31 10.3 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 ORX69879.1 - 0.0082 16.7 0.4 7.3 7.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ORX69879.1 - 0.023 14.3 1.5 0.091 12.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ORX69879.1 - 0.047 14.1 0.0 3.3 8.2 0.0 2.8 3 0 0 3 3 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 ORX69879.1 - 0.057 12.8 0.5 0.85 8.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF815 PF05673.13 ORX69879.1 - 0.1 11.7 0.0 4.9 6.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA PF00004.29 ORX69879.1 - 0.12 12.8 0.2 1.4 9.4 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 ORX69879.1 - 0.12 12.1 0.5 4.4 7.0 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ORX69879.1 - 0.13 11.8 0.1 18 4.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 ORX69879.1 - 0.14 11.0 2.8 3.1 6.6 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.17 ORX69879.1 - 0.15 12.1 4.8 0.72 9.9 0.4 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain DEAD PF00270.29 ORX69879.1 - 0.16 11.7 0.2 5.5 6.7 0.0 2.9 3 0 0 3 3 3 0 DEAD/DEAH box helicase Roc PF08477.13 ORX69879.1 - 0.21 11.8 0.6 29 4.9 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Adeno_IVa2 PF02456.15 ORX69879.1 - 0.22 10.3 1.0 0.55 9.0 0.1 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein IstB_IS21 PF01695.17 ORX69879.1 - 0.23 11.2 3.3 5.3 6.7 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX69879.1 - 0.24 11.1 7.5 4.7 6.9 0.2 4.2 5 0 0 5 5 5 0 AAA domain ABC_ATPase PF09818.9 ORX69879.1 - 0.51 9.1 1.8 2.9 6.6 0.5 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class CbiA PF01656.23 ORX69879.1 - 0.59 10.2 1.5 42 4.2 0.1 3.6 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Opacity PF02462.15 ORX69880.1 - 0.0097 16.0 0.7 48 4.1 0.0 3.8 4 1 0 4 4 4 3 Opacity family porin protein DUF4279 PF14106.6 ORX69880.1 - 0.022 14.9 0.0 1e+02 3.2 0.0 4.9 7 0 0 7 7 7 0 Domain of unknown function (DUF4279) Pyr_redox_2 PF07992.14 ORX69881.1 - 8.8e-26 90.8 0.0 1.6e-25 90.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX69881.1 - 1.4e-09 38.4 0.1 1.3e-05 25.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX69881.1 - 0.00034 19.9 0.0 0.044 12.9 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ORX69881.1 - 0.0064 16.5 0.4 9.6 6.2 0.0 3.8 4 0 0 4 4 4 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ORX69881.1 - 0.093 12.0 0.6 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 ORX69881.1 - 0.095 12.8 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 ORX69881.1 - 0.1 12.2 0.8 5 6.6 0.0 2.6 3 0 0 3 3 3 0 FAD dependent oxidoreductase Rpr2 PF04032.16 ORX69882.1 - 2.4e-18 66.2 1.1 3.1e-18 65.8 1.1 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain LPMO_10 PF03067.15 ORX69883.1 - 1.9e-07 32.0 0.2 2.6e-07 31.5 0.2 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX69883.1 - 0.0024 17.8 0.2 0.0077 16.2 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 DUF3446 PF11928.8 ORX69885.1 - 2.5 8.4 11.6 1.2 9.4 8.5 1.9 1 1 1 2 2 2 0 Early growth response N-terminal domain DEC-1_N PF04625.13 ORX69885.1 - 4.1 6.3 10.8 4.8 6.1 10.8 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LPMO_10 PF03067.15 ORX69887.1 - 2.7e-08 34.7 0.7 5.3e-08 33.7 0.7 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 ORX69887.1 - 0.0057 16.6 1.0 4.2 7.3 0.1 3.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 61 EAP30 PF04157.16 ORX69888.1 - 4.7e-57 193.0 0.1 5.3e-57 192.8 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family MHC_I_3 PF16497.5 ORX69888.1 - 0.038 13.5 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 MHC-I family domain NDUF_B8 PF05821.11 ORX69889.1 - 2.2e-07 30.9 0.2 2.8e-07 30.6 0.2 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) PhoLip_ATPase_C PF16212.5 ORX69890.1 - 3.8e-65 220.1 24.0 3.8e-65 220.1 24.0 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX69890.1 - 1.7e-22 78.9 0.2 1.7e-22 78.9 0.2 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ORX69890.1 - 8.1e-11 41.8 0.0 3e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX69890.1 - 1.4e-10 41.8 2.6 7.2e-07 29.7 0.3 3.7 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX69890.1 - 6.9e-08 32.5 0.0 8.9e-07 28.9 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX69890.1 - 0.0025 17.6 0.2 0.007 16.1 0.2 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Tox-HDC PF15656.6 ORX69890.1 - 0.059 13.6 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature DUF3852 PF12963.7 ORX69890.1 - 1.1 9.6 6.5 0.3 11.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3852) DUF2298 PF10060.9 ORX69891.1 - 0.024 13.3 6.3 0.26 9.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) NDK PF00334.19 ORX69892.1 - 6.6e-34 116.8 0.0 7.6e-34 116.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Homeobox_KN PF05920.11 ORX69893.1 - 2.4e-15 56.1 0.1 5.5e-15 55.0 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX69893.1 - 3.2e-07 30.1 0.0 1.2e-06 28.2 0.1 1.9 2 0 0 2 2 2 1 Homeodomain CHAP PF05257.16 ORX69894.1 - 1.4e-13 51.2 4.2 3e-13 50.1 4.2 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX69894.1 - 0.005 17.1 0.2 0.013 15.7 0.2 1.7 1 1 0 1 1 1 1 Bacterial SH3 domain Cofac_haem_bdg PF04187.13 ORX69896.1 - 0.075 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Mannosyl_trans2 PF04188.13 ORX69897.1 - 4e-89 300.0 23.4 4.8e-89 299.7 23.4 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) UcrQ PF02939.16 ORX69898.1 - 2.5e-27 94.6 0.6 3e-27 94.3 0.6 1.0 1 0 0 1 1 1 1 UcrQ family Aldo_ket_red PF00248.21 ORX69899.1 - 7.4e-48 163.2 0.0 4.9e-47 160.5 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 ORX69900.1 - 3e-26 92.2 56.7 4.8e-15 55.3 19.9 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69900.1 - 0.0049 15.8 6.8 0.0049 15.8 6.8 3.3 1 1 2 3 3 3 2 Sugar (and other) transporter TssN PF17555.2 ORX69900.1 - 1.1 8.6 9.6 0.19 11.1 0.1 2.4 2 0 0 2 2 2 0 Type VI secretion system, TssN MFS_1 PF07690.16 ORX69901.1 - 1.6e-18 66.7 49.7 1.6e-18 66.7 49.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69901.1 - 2.7e-05 23.2 15.8 2.7e-05 23.2 15.8 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter Pribosyltran PF00156.27 ORX69902.1 - 3.1e-16 59.3 0.0 1.7e-15 56.9 0.0 1.8 1 1 1 2 2 2 1 Phosphoribosyl transferase domain PA PF02225.22 ORX69902.1 - 0.0058 16.6 0.4 0.0087 16.1 0.4 1.3 1 0 0 1 1 1 1 PA domain PRTase_2 PF15609.6 ORX69902.1 - 0.0062 16.1 0.0 0.0092 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase SMC_N PF02463.19 ORX69903.1 - 9.6e-78 260.6 0.0 2.1e-77 259.5 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX69903.1 - 6.9e-27 94.1 0.0 1.9e-26 92.7 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX69903.1 - 8.7e-15 55.3 0.9 7.8e-07 29.2 0.1 3.2 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ORX69903.1 - 7.2e-06 25.9 13.8 7.2e-06 25.9 13.8 3.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ORX69903.1 - 6.3e-05 22.6 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-K PF11802.8 ORX69903.1 - 0.0011 18.5 16.1 0.0011 18.5 16.1 5.3 4 1 2 6 6 6 2 Centromere-associated protein K ABC_tran PF00005.27 ORX69903.1 - 0.077 13.5 0.1 0.077 13.5 0.1 5.4 4 1 0 5 5 5 0 ABC transporter AAA_22 PF13401.6 ORX69903.1 - 0.094 13.0 0.3 7.3 6.9 0.0 3.7 3 0 0 3 3 3 0 AAA domain Spc7 PF08317.11 ORX69903.1 - 0.4 9.5 104.6 0.9 8.4 14.8 7.1 3 2 4 7 7 7 0 Spc7 kinetochore protein RPAP3_C PF13877.6 ORX69904.1 - 3.3e-15 56.4 0.0 5.8e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_2 PF07719.17 ORX69904.1 - 2.7e-14 52.0 2.4 0.0003 20.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX69904.1 - 7.9e-14 50.8 1.2 0.00016 21.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX69904.1 - 6.1e-10 38.5 1.0 0.039 14.2 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX69904.1 - 6.6e-10 38.5 1.8 1.1e-05 25.0 0.1 3.4 1 1 2 3 3 3 2 TPR repeat TPR_9 PF13371.6 ORX69904.1 - 7.5e-07 29.2 3.9 0.0015 18.6 2.8 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX69904.1 - 2.5e-06 28.0 12.1 3.2e-06 27.7 1.3 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX69904.1 - 7.5e-06 26.4 6.3 0.0007 20.2 0.0 4.1 2 1 2 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX69904.1 - 2.7e-05 24.1 0.9 0.14 12.3 0.1 3.4 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 ORX69904.1 - 5.9e-05 23.2 1.2 0.00074 19.7 0.1 3.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX69904.1 - 8e-05 22.4 0.3 0.21 11.7 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX69904.1 - 0.0023 18.4 4.7 0.0059 17.1 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX69904.1 - 0.0093 16.2 6.7 1.8 8.9 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 ORX69904.1 - 0.015 15.9 0.2 6.3 7.7 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX69904.1 - 0.034 14.4 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ORX69904.1 - 0.083 13.3 2.3 11 6.4 0.9 3.4 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 ORX69904.1 - 0.084 13.6 4.7 82 4.2 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPM_phosphatase PF04536.14 ORX69904.1 - 0.22 11.7 0.8 1.2 9.3 0.3 2.3 3 0 0 3 3 3 0 TPM domain TPR_10 PF13374.6 ORX69904.1 - 1.2 9.1 3.3 11 6.1 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Ada3 PF10198.9 ORX69905.1 - 1e-36 126.0 9.3 1.3e-35 122.4 4.6 2.4 2 0 0 2 2 2 2 Histone acetyltransferases subunit 3 LprI PF07007.12 ORX69905.1 - 0.027 15.1 1.9 0.081 13.6 0.3 2.3 2 0 0 2 2 2 0 Lysozyme inhibitor LprI DUF4404 PF14357.6 ORX69905.1 - 2.7 8.7 10.2 1.8 9.3 1.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) K-box PF01486.17 ORX69905.1 - 7 6.9 10.4 0.78 10.0 0.3 2.7 2 1 0 2 2 2 0 K-box region Rft-1 PF04506.13 ORX69906.1 - 4.5e-115 385.3 11.6 5.6e-115 385.0 11.6 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 ORX69906.1 - 1.3e-06 28.1 6.2 1.3e-06 28.1 6.2 2.7 2 1 0 3 3 3 2 Polysaccharide biosynthesis protein YpmT PF17431.2 ORX69906.1 - 0.057 13.4 0.1 0.19 11.7 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized YmpT-like EMP70 PF02990.16 ORX69906.1 - 3.4 6.2 10.4 1.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Endomembrane protein 70 SMK-1 PF04802.15 ORX69907.1 - 2.4e-66 223.2 3.5 3.3e-66 222.8 2.2 1.8 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 Vps26 PF03643.15 ORX69909.1 - 3e-123 410.2 4.7 3.5e-123 410.0 4.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ORX69909.1 - 0.0054 16.8 1.6 0.51 10.4 1.5 3.4 1 1 1 2 2 2 1 Arrestin (or S-antigen), N-terminal domain SURF1 PF02104.15 ORX69910.1 - 1.9e-39 135.7 0.1 2.4e-39 135.4 0.1 1.1 1 0 0 1 1 1 1 SURF1 family Acetyltransf_14 PF03421.16 ORX69910.1 - 0.096 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 YopJ Serine/Threonine acetyltransferase DUF899 PF05988.12 ORX69911.1 - 0.00077 19.0 1.0 0.26 10.8 0.1 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF899) Pkinase PF00069.25 ORX69912.1 - 3.7e-07 29.8 0.0 6.9e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69912.1 - 0.00058 19.2 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase CbtB PF09489.10 ORX69912.1 - 0.1 12.7 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Cupin_8 PF13621.6 ORX69913.1 - 1.1e-08 35.2 0.2 5.3e-08 32.9 0.2 2.0 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ORX69913.1 - 2.9e-08 34.1 0.7 5.6e-07 30.0 0.7 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 ORX69913.1 - 0.00019 21.3 14.5 0.00034 20.4 14.5 1.4 1 0 0 1 1 1 1 PHD-finger JHD PF17811.1 ORX69913.1 - 0.0008 19.9 0.0 0.0016 19.0 0.0 1.5 1 0 0 1 1 1 1 Jumonji helical domain Cupin_4 PF08007.12 ORX69913.1 - 0.0018 17.8 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein FmiP_Thoc5 PF09766.9 ORX69914.1 - 1.4e-12 47.6 9.2 1.4e-12 47.6 9.2 1.7 1 1 1 2 2 2 1 Fms-interacting protein/Thoc5 NPV_P10 PF05531.12 ORX69914.1 - 0.048 14.1 2.3 2.6 8.6 0.1 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Sec8_exocyst PF04048.14 ORX69914.1 - 0.052 13.4 0.4 0.85 9.5 0.1 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF4665 PF15679.5 ORX69914.1 - 0.1 13.3 2.1 0.88 10.2 0.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) BLOC1_2 PF10046.9 ORX69914.1 - 0.28 11.5 2.6 2.2 8.6 0.1 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LMBR1 PF04791.16 ORX69914.1 - 0.65 8.8 1.4 0.77 8.6 1.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Rootletin PF15035.6 ORX69914.1 - 4.4 7.3 9.5 5.9 6.9 0.7 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TRM PF02005.16 ORX69915.1 - 2.4e-133 445.0 0.0 3e-133 444.6 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 ORX69915.1 - 0.0059 16.4 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TP_methylase PF00590.20 ORX69916.1 - 4.1e-21 75.9 0.0 7e-21 75.2 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases F-box-like PF12937.7 ORX69917.1 - 0.11 12.4 0.4 0.27 11.1 0.4 1.7 1 1 0 1 1 1 0 F-box-like DUF899 PF05988.12 ORX69918.1 - 0.00077 19.0 1.0 0.26 10.8 0.1 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF899) Ribosomal_S17 PF00366.20 ORX69919.1 - 2.1e-21 75.8 3.0 2.5e-21 75.5 3.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 SAM_4 PF18017.1 ORX69919.1 - 0.14 12.1 0.1 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Rad50_zn_hook PF04423.14 ORX69920.1 - 0.0099 15.7 3.1 1 9.2 0.0 3.5 4 0 0 4 4 4 2 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 ORX69920.1 - 0.029 14.9 1.1 3.6 8.2 0.0 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2 PF00096.26 ORX69920.1 - 0.056 13.9 0.9 3.4 8.3 0.0 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX69920.1 - 0.083 13.8 1.5 6.3 7.9 0.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 ORX69920.1 - 0.17 12.0 0.4 19 5.5 0.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 ORX69920.1 - 0.19 12.1 0.4 13 6.2 0.0 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Slx4 PF09494.10 ORX69921.1 - 3.7e-08 33.2 0.0 1.9e-07 30.9 0.0 2.1 2 0 0 2 2 2 1 Slx4 endonuclease Rho_N PF07498.12 ORX69921.1 - 0.0062 16.4 0.2 0.011 15.6 0.2 1.5 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain ZZ PF00569.17 ORX69923.1 - 6.1e-36 122.0 64.4 1.3e-09 37.8 6.0 5.4 5 0 0 5 5 5 5 Zinc finger, ZZ type N_BRCA1_IG PF16158.5 ORX69923.1 - 8.8e-27 93.8 0.1 4.3e-26 91.6 0.1 2.3 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene C1_2 PF03107.16 ORX69923.1 - 0.00042 20.6 61.6 0.02 15.2 5.3 5.7 5 0 0 5 5 5 4 C1 domain ABC_tran_CTD PF16326.5 ORX69923.1 - 0.79 10.0 2.6 18 5.7 0.2 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain Ribosomal_L24e PF01246.20 ORX69924.1 - 1.6e-33 114.8 6.4 3.3e-33 113.7 6.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e Ribosomal_L13 PF00572.18 ORX69925.1 - 3.6e-54 182.3 0.1 4.5e-54 182.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 Proteasom_PSMB PF10508.9 ORX69926.1 - 3e-48 164.6 0.0 4.1e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit Rcd1 PF04078.13 ORX69926.1 - 0.013 14.8 0.0 0.22 10.8 0.0 2.3 1 1 1 2 2 2 0 Cell differentiation family, Rcd1-like Bystin PF05291.11 ORX69927.1 - 3.4e-141 469.7 0.5 4.5e-141 469.3 0.5 1.1 1 0 0 1 1 1 1 Bystin Pes-10 PF07149.11 ORX69927.1 - 0.1 11.7 7.3 0.15 11.1 7.3 1.2 1 0 0 1 1 1 0 Pes-10 DUF789 PF05623.12 ORX69927.1 - 0.32 10.6 4.3 0.48 10.0 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF789) DNA_pol_phi PF04931.13 ORX69927.1 - 3.8 5.5 15.0 5.7 4.9 15.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Chorismate_bind PF00425.18 ORX69928.1 - 5.6e-95 317.8 0.0 1.2e-94 316.7 0.0 1.5 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ORX69928.1 - 1.4e-28 99.9 0.1 5.7e-27 94.7 0.0 2.7 3 0 0 3 3 3 1 Anthranilate synthase component I, N terminal region Ribosomal_L7Ae PF01248.26 ORX69929.1 - 7.5e-25 86.5 3.9 9.1e-25 86.2 3.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Gin PF10764.9 ORX69929.1 - 0.12 12.3 0.6 0.19 11.7 0.6 1.3 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin ZZ PF00569.17 ORX69930.1 - 1.5e-08 34.3 3.7 2.9e-08 33.4 3.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 ORX69930.1 - 1.3e-07 31.7 0.1 2.3e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX69930.1 - 0.00023 21.3 0.1 0.00044 20.4 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-UBR PF02207.20 ORX69930.1 - 4.1 7.6 8.2 46 4.3 8.2 2.1 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Pkinase PF00069.25 ORX69932.1 - 1.1e-52 179.0 0.0 1.4e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69932.1 - 1.5e-33 116.2 0.0 2e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX69932.1 - 0.00018 20.9 0.1 0.00038 19.9 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX69932.1 - 0.00053 19.4 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX69932.1 - 0.0011 17.8 0.3 0.63 8.8 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase FTA2 PF13095.6 ORX69932.1 - 0.0023 17.6 0.0 0.63 9.6 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX69932.1 - 0.0038 17.2 0.1 0.13 12.1 0.4 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX69932.1 - 0.03 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase ATE_C PF04377.15 ORX69933.1 - 1.9e-45 154.8 1.8 2.6e-45 154.3 1.8 1.2 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 ORX69933.1 - 4.1e-22 78.3 2.6 3.4e-21 75.4 1.8 2.4 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 ORX69933.1 - 0.047 13.8 0.2 0.12 12.5 0.1 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain XPG_I PF00867.18 ORX69934.1 - 8.9e-14 51.6 0.3 1.9e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ORX69934.1 - 9.4e-14 51.7 0.0 1.8e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ORX69934.1 - 0.0011 19.5 0.0 0.0034 18.0 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ORX69934.1 - 0.014 16.0 0.0 0.069 13.8 0.0 2.2 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF421 PF04239.12 ORX69934.1 - 0.098 12.4 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF421) HHH_2 PF12826.7 ORX69934.1 - 0.16 12.1 0.0 0.46 10.6 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif PspB PF06667.12 ORX69934.1 - 3 8.0 5.1 3.9 7.6 1.1 2.7 3 0 0 3 3 3 0 Phage shock protein B Septin PF00735.18 ORX69935.1 - 9e-96 320.4 0.0 1.1e-95 320.2 0.0 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX69935.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX69935.1 - 0.012 15.6 0.0 0.094 12.8 0.0 2.3 1 1 0 1 1 1 0 Dynamin family RsgA_GTPase PF03193.16 ORX69935.1 - 0.013 15.4 0.1 0.055 13.4 0.1 1.9 1 1 0 1 1 1 0 RsgA GTPase DUF302 PF03625.14 ORX69935.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF302 AIG1 PF04548.16 ORX69935.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Steroid_dh PF02544.16 ORX69936.1 - 9.5e-41 139.3 0.0 1.5e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ORX69936.1 - 7.6e-05 22.3 0.0 0.00016 21.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ORX69936.1 - 0.00011 22.5 0.4 0.00011 22.5 0.4 2.5 2 2 0 3 3 3 1 Phospholipid methyltransferase DUF2427 PF10348.9 ORX69936.1 - 0.019 14.7 3.7 0.042 13.6 0.1 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF2427) PhoR PF11808.8 ORX69936.1 - 0.25 11.8 0.1 0.25 11.8 0.1 2.9 4 0 0 4 4 4 0 Phosphate regulon sensor protein PhoR DUF1258 PF06869.12 ORX69937.1 - 0.074 12.5 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Prenyltrans PF00432.21 ORX69941.1 - 0.076 12.8 1.6 0.13 12.0 1.6 1.3 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat NTF2 PF02136.20 ORX69942.1 - 3.8e-27 95.3 0.1 5.7e-27 94.7 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 ORX69942.1 - 0.0044 16.8 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SurA_N_2 PF13623.6 ORX69942.1 - 0.12 12.2 0.4 0.83 9.5 0.1 2.3 2 0 0 2 2 2 0 SurA N-terminal domain Merozoite_SPAM PF07133.11 ORX69942.1 - 0.63 10.0 21.3 1.1 9.2 21.3 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Endostatin PF06482.11 ORX69942.1 - 0.84 9.0 2.9 1.3 8.4 2.9 1.4 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2151 PF10221.9 ORX69942.1 - 5.2 5.5 6.7 7.5 5.0 6.7 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator GREB1 PF15782.5 ORX69942.1 - 5.5 4.0 6.5 6.5 3.7 6.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Borrelia_P83 PF05262.11 ORX69942.1 - 7.9 4.8 17.5 11 4.3 17.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Pkinase PF00069.25 ORX69943.1 - 1.7e-34 119.4 0.0 2e-33 115.9 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX69943.1 - 3.9e-13 49.3 0.0 1.2e-11 44.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ORX69943.1 - 0.013 14.8 0.1 0.022 14.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX69943.1 - 0.084 12.5 0.2 0.14 11.8 0.2 1.3 1 0 0 1 1 1 0 RIO1 family WD40 PF00400.32 ORX69944.1 - 9.3e-10 39.0 8.5 0.00036 21.3 1.1 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat Kelch_6 PF13964.6 ORX69944.1 - 0.016 15.5 0.1 3.6 8.0 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Holin_2-3 PF13272.6 ORX69944.1 - 0.21 11.9 0.0 0.36 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin FERM_f0 PF16511.5 ORX69945.1 - 0.00062 20.0 0.2 0.019 15.3 0.1 2.4 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM PH PF00169.29 ORX69945.1 - 0.00074 20.0 0.0 0.15 12.6 0.0 2.8 2 0 0 2 2 2 2 PH domain DUF3040 PF11239.8 ORX69946.1 - 0.062 13.6 2.0 0.066 13.5 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Rx_N PF18052.1 ORX69946.1 - 0.11 12.8 1.3 0.33 11.2 0.1 2.4 3 0 0 3 3 3 0 Rx N-terminal domain CSN7a_helixI PF18392.1 ORX69947.1 - 4.7 7.2 11.0 19 5.2 0.3 3.3 3 0 0 3 3 3 0 COP9 signalosome complex subunit 7a helix I domain MFS_1 PF07690.16 ORX69948.1 - 1e-41 143.1 41.7 1e-41 143.1 41.7 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69948.1 - 9.9e-17 60.9 28.8 9.1e-16 57.8 7.4 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter DNA_primase_S PF01896.19 ORX69950.1 - 4.7e-57 192.9 0.1 6.3e-57 192.5 0.1 1.2 1 0 0 1 1 1 1 DNA primase small subunit Adaptin_N PF01602.20 ORX69951.1 - 7.3e-141 470.3 5.1 8.5e-141 470.1 5.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX69951.1 - 7.3e-60 201.7 4.8 3.4e-58 196.2 0.0 2.9 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX69951.1 - 2.5e-18 66.3 3.9 2.2e-06 28.0 0.0 6.1 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.22 ORX69951.1 - 1.9e-08 33.9 7.0 0.0032 17.6 0.0 5.9 6 0 0 6 6 4 2 HEAT repeat HEAT_EZ PF13513.6 ORX69951.1 - 2.9e-06 27.7 3.2 0.73 10.4 0.0 6.2 5 1 1 6 6 6 2 HEAT-like repeat RTP1_C1 PF10363.9 ORX69951.1 - 1.8e-05 24.9 0.6 0.017 15.3 0.0 4.5 4 1 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 ORX69951.1 - 0.00013 21.6 1.8 0.25 10.9 0.0 4.0 3 1 1 4 4 4 2 CLASP N terminal Arm PF00514.23 ORX69951.1 - 0.0028 17.6 4.0 11 6.3 0.0 5.5 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat Sec7_N PF12783.7 ORX69951.1 - 0.0036 17.2 4.1 0.023 14.6 0.9 3.1 2 1 1 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal IFRD PF05004.13 ORX69951.1 - 0.0042 16.2 0.5 1.9 7.5 0.0 3.3 2 1 0 3 3 3 1 Interferon-related developmental regulator (IFRD) TIP120 PF08623.10 ORX69951.1 - 0.0078 16.0 2.4 0.45 10.3 0.1 3.1 3 1 0 3 3 3 1 TATA-binding protein interacting (TIP20) DUF1548 PF07579.11 ORX69951.1 - 0.089 13.1 0.2 8 6.8 0.0 3.4 2 2 1 3 3 3 0 Domain of Unknown Function (DUF1548) DUF4791 PF16039.5 ORX69951.1 - 0.15 11.6 0.0 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4791) Cu-oxidase_3 PF07732.15 ORX69952.1 - 1.7e-35 121.6 0.8 9.3e-32 109.5 0.1 3.3 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX69952.1 - 7.4e-33 113.2 9.0 3.6e-32 111.0 1.4 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX69952.1 - 9.7e-25 87.5 0.3 8.6e-20 71.5 0.0 2.9 3 0 0 3 3 3 2 Multicopper oxidase DUF5425 PF17472.2 ORX69953.1 - 0.031 15.1 0.0 0.058 14.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5425) DEK_C PF08766.11 ORX69953.1 - 0.041 13.8 3.2 0.055 13.4 0.7 2.5 2 1 0 2 2 2 0 DEK C terminal domain Stm1_N PF09598.10 ORX69953.1 - 4.3 8.3 9.6 25 5.8 5.4 2.5 2 0 0 2 2 2 0 Stm1 Asparaginase PF00710.20 ORX69955.1 - 1.1e-56 191.4 0.0 7.8e-56 188.7 0.0 2.1 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ORX69955.1 - 9.8e-30 103.1 0.0 1.9e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_4 PF13637.6 ORX69955.1 - 3.8e-22 78.3 0.3 1.2e-07 32.2 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX69955.1 - 1.9e-21 76.4 0.0 3e-13 50.1 0.0 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX69955.1 - 8e-15 53.5 0.1 7e-05 22.9 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ORX69955.1 - 4.2e-13 49.2 0.1 8.1e-07 29.2 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX69955.1 - 2.9e-10 40.1 0.0 0.00076 19.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat ANAPC4_WD40 PF12894.7 ORX69956.1 - 0.00073 19.8 0.0 0.9 9.9 0.0 4.8 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 ORX69956.1 - 0.0031 16.3 0.1 2.2 6.9 0.0 3.3 4 1 0 4 4 4 2 Lethal giant larvae(Lgl) like, C-terminal HSP90 PF00183.18 ORX69957.1 - 3.7e-224 745.4 24.0 4.9e-224 745.0 24.0 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ORX69957.1 - 2e-14 54.0 0.1 3.7e-14 53.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX69957.1 - 9.5e-11 41.7 0.1 2.4e-10 40.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Dzip-like_N PF13815.6 ORX69958.1 - 0.05 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Pkinase PF00069.25 ORX69959.1 - 4e-05 23.1 0.5 5.7e-05 22.6 0.4 1.2 1 1 0 1 1 1 1 Protein kinase domain ATP-gua_Ptrans PF00217.19 ORX69959.1 - 0.014 14.8 0.1 0.018 14.5 0.1 1.2 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, C-terminal catalytic domain RIO1 PF01163.22 ORX69959.1 - 0.022 14.4 0.2 0.029 14.0 0.2 1.2 1 0 0 1 1 1 0 RIO1 family PPR_2 PF13041.6 ORX69960.1 - 4.9e-19 68.3 4.5 4.9e-07 29.9 0.1 8.2 6 2 3 9 9 9 4 PPR repeat family PPR PF01535.20 ORX69960.1 - 4.8e-16 57.8 2.8 9.8e-05 22.4 0.0 8.0 8 0 0 8 8 8 3 PPR repeat PPR_3 PF13812.6 ORX69960.1 - 3.2e-13 49.6 0.3 0.0002 21.4 0.0 6.3 7 0 0 7 7 7 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX69960.1 - 4e-12 45.9 0.2 0.0023 17.4 0.0 5.0 4 1 1 5 5 5 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX69960.1 - 1e-08 34.7 0.2 9.2e-06 25.3 0.0 4.3 3 0 0 3 3 3 1 PPR repeat AEP1 PF17049.5 ORX69960.1 - 0.073 12.1 0.1 0.17 10.9 0.1 1.5 1 0 0 1 1 1 0 ATPase expression protein 1 CYTL1 PF15153.6 ORX69960.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Cytokine-like protein 1 Glyco_transf_8 PF01501.20 ORX69961.1 - 1.1e-17 64.5 0.0 6.4e-09 35.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 ORX69961.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Glyco_transf_8 PF01501.20 ORX69962.1 - 7.4e-06 25.7 0.0 1.3e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 WD40 PF00400.32 ORX69963.1 - 1.8e-12 47.5 5.6 0.0014 19.4 0.1 5.1 3 1 0 3 3 3 3 WD domain, G-beta repeat Fer2_3 PF13085.6 ORX69964.1 - 1.1e-33 115.5 0.0 1.9e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 ORX69964.1 - 5.4e-09 36.5 6.4 5.4e-09 36.5 6.4 2.4 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ORX69964.1 - 6.6e-07 29.7 8.1 6.6e-07 29.7 8.1 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 ORX69964.1 - 7.4e-07 29.2 3.0 7.4e-07 29.2 3.0 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 ORX69964.1 - 0.00017 21.4 1.7 0.0084 16.0 0.2 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 ORX69964.1 - 0.16 12.2 12.3 0.12 12.5 7.9 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 ORX69964.1 - 0.2 11.9 4.4 0.51 10.5 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 ORX69964.1 - 0.26 12.2 7.6 2.7 9.0 0.9 3.0 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 ORX69964.1 - 1.7 9.3 16.4 0.089 13.4 8.3 2.8 2 2 1 3 3 3 0 4Fe-4S dicluster domain PhyH PF05721.13 ORX69965.1 - 1.6e-26 93.9 0.0 1.9e-26 93.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 ORX69965.1 - 0.00096 19.5 0.0 0.0018 18.6 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 ORX69965.1 - 0.15 12.9 0.0 0.31 12.0 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Sugar_tr PF00083.24 ORX69967.1 - 9.8e-46 156.5 20.2 2.4e-45 155.3 20.2 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX69967.1 - 2.2e-37 128.8 24.9 2.2e-37 128.8 24.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF742 PF05331.11 ORX69967.1 - 0.071 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF742) BT1 PF03092.16 ORX69967.1 - 0.26 9.5 5.4 0.54 8.4 5.4 1.4 1 1 0 1 1 1 0 BT1 family AdoMet_MTase PF07757.13 ORX69968.1 - 1.1e-35 122.3 0.0 1.9e-35 121.6 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 ORX69968.1 - 0.0029 17.6 0.2 0.31 11.0 0.0 2.3 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX69968.1 - 0.0078 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Sel_put PF04328.13 ORX69968.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Selenoprotein, putative MetW PF07021.12 ORX69968.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 ORX69968.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ORX69968.1 - 0.17 12.6 0.0 0.4 11.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DASH_Dad2 PF08654.10 ORX69969.1 - 1.2e-07 32.1 2.3 3.3e-07 30.6 2.3 1.6 1 1 0 1 1 1 1 DASH complex subunit Dad2 SH3BGR PF04908.15 ORX69970.1 - 1.7e-14 53.7 0.0 4.8e-14 52.3 0.0 1.8 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 ORX69970.1 - 2.1e-05 24.6 0.0 6.2e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 Glutaredoxin ATP-synt_E PF05680.12 ORX69971.1 - 1.9e-13 50.6 0.0 2.2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 ATP synthase E chain Sin3_corepress PF08295.12 ORX69971.1 - 0.01 15.9 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 Sin3 family co-repressor DNA_pol_phi PF04931.13 ORX69972.1 - 4.8e-160 534.2 0.0 6.6e-160 533.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase phi ANAPC4_WD40 PF12894.7 ORX69973.1 - 1e-11 45.0 3.1 0.00078 19.7 0.2 5.2 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX69973.1 - 3.8e-11 43.2 0.0 0.0019 18.1 0.0 5.4 3 2 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ORX69973.1 - 1.2e-06 29.2 6.9 2.1 9.3 0.0 8.1 8 1 0 8 8 8 1 WD domain, G-beta repeat IKI3 PF04762.12 ORX69973.1 - 0.00057 18.0 5.6 0.17 9.9 2.5 3.6 2 2 1 4 4 4 2 IKI3 family TruB_C PF09142.11 ORX69973.1 - 0.0027 17.4 0.1 8.1 6.3 0.1 4.1 4 0 0 4 4 4 1 tRNA Pseudouridine synthase II, C terminal Cytochrom_D1 PF02239.16 ORX69973.1 - 0.014 14.0 0.0 0.037 12.6 0.0 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 ORX69973.1 - 0.088 12.8 8.4 8.1 6.5 0.0 5.3 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF2678 PF10856.8 ORX69974.1 - 7.1e-18 64.6 0.8 7.7e-18 64.5 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) WD40 PF00400.32 ORX69975.1 - 1.3e-35 120.8 22.1 1.7e-07 31.8 1.0 9.2 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX69975.1 - 7.9e-23 80.6 0.0 1.1e-09 38.5 0.0 6.1 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ORX69975.1 - 1.4e-05 24.9 0.6 0.1 12.5 0.1 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat RAB3GAP2_N PF14655.6 ORX69975.1 - 0.0002 20.8 0.0 0.27 10.4 0.0 2.6 1 1 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40_like PF17005.5 ORX69975.1 - 0.00079 18.8 0.0 1.9 7.7 0.0 3.6 3 2 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ORX69975.1 - 0.0064 15.5 1.3 1.5 7.7 0.0 4.2 3 1 3 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX69975.1 - 0.0077 16.1 0.0 6.2 6.7 0.0 2.8 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Lactonase PF10282.9 ORX69975.1 - 0.051 12.8 0.0 6.5 5.9 0.0 3.2 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller Coatomer_WDAD PF04053.14 ORX69975.1 - 0.2 10.6 0.0 1.3 8.0 0.0 2.1 2 1 0 2 2 2 0 Coatomer WD associated region PQQ_3 PF13570.6 ORX69975.1 - 5.6 7.6 14.4 0.98 10.0 0.1 6.1 5 1 1 6 6 6 0 PQQ-like domain AFG1_ATPase PF03969.16 ORX69976.1 - 1.1e-111 373.3 0.1 2.1e-107 359.2 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 ORX69976.1 - 0.00016 22.1 4.3 0.022 15.1 0.0 3.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.6 ORX69976.1 - 0.00047 20.2 0.0 0.0016 18.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX69976.1 - 0.0034 17.7 0.0 0.0095 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ORX69976.1 - 0.016 15.6 0.0 0.054 13.9 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ORX69976.1 - 0.029 14.1 0.0 0.13 11.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ORX69976.1 - 0.034 13.9 0.1 0.096 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ORX69976.1 - 0.12 12.4 0.0 0.35 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 ORX69976.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mrx7 PF10906.8 ORX69976.1 - 0.18 12.1 3.3 0.25 11.6 0.1 2.7 3 0 0 3 3 3 0 MIOREX complex component 7 Ribosomal_S25 PF03297.15 ORX69977.1 - 3.3e-35 120.3 0.1 3.7e-35 120.2 0.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.7 ORX69977.1 - 0.011 15.6 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 0 MarR family HTH_CodY PF08222.11 ORX69977.1 - 0.1 12.1 0.2 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 CodY helix-turn-helix domain Swi5 PF07061.11 ORX69978.1 - 1.2e-15 57.3 0.3 1.6e-15 57.0 0.3 1.2 1 0 0 1 1 1 1 Swi5 SF1-HH PF16275.5 ORX69979.1 - 5.5e-34 116.9 0.8 1e-33 116.0 0.8 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 ORX69979.1 - 7e-11 41.7 6.7 4.5e-06 26.5 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 ORX69979.1 - 1.3e-06 28.1 1.4 3.2e-06 26.9 1.4 1.8 1 1 0 1 1 1 1 KH domain zf-CCHC_2 PF13696.6 ORX69979.1 - 0.00034 20.4 9.0 0.08 12.8 0.6 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 ORX69979.1 - 0.006 16.3 7.8 0.021 14.6 0.2 2.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_6 PF15288.6 ORX69979.1 - 0.0085 15.9 9.4 0.011 15.5 0.6 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 ORX69979.1 - 0.019 14.9 12.8 0.13 12.2 0.3 2.8 2 1 1 3 3 3 0 Zinc knuckle YdiH PF15930.5 ORX69979.1 - 0.15 12.3 0.6 0.45 10.7 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function Prim_Zn_Ribbon PF08273.12 ORX69979.1 - 0.21 11.9 3.3 0.45 10.8 3.3 1.5 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase SWIRM-assoc_2 PF16496.5 ORX69979.1 - 0.28 10.0 1.5 0.41 9.5 1.5 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DnaJ_CXXCXGXG PF00684.19 ORX69979.1 - 0.41 11.0 7.2 0.25 11.7 4.8 1.9 2 0 0 2 2 2 0 DnaJ central domain Ribul_P_3_epim PF00834.19 ORX69980.1 - 7.4e-73 244.2 0.0 8.5e-73 244.0 0.0 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 ORX69980.1 - 0.0027 17.5 0.1 0.011 15.5 0.0 2.0 2 1 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain HMGL-like PF00682.19 ORX69980.1 - 0.0052 16.4 0.0 0.033 13.7 0.1 1.9 2 0 0 2 2 2 1 HMGL-like DUF596 PF04591.12 ORX69980.1 - 0.039 14.1 0.0 0.1 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF596 PcrB PF01884.17 ORX69980.1 - 0.063 12.7 0.5 0.21 11.0 0.1 1.8 1 1 0 2 2 2 0 PcrB family CCDC-167 PF15188.6 ORX69981.1 - 0.027 14.8 0.1 0.047 14.0 0.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Mod_r PF07200.13 ORX69981.1 - 0.054 13.6 0.0 0.065 13.3 0.0 1.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein NYD-SP28 PF14772.6 ORX69981.1 - 0.074 13.1 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Sperm tail THOC7 PF05615.13 ORX69981.1 - 0.075 13.3 0.6 0.12 12.7 0.6 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 Lactamase_B_4 PF13691.6 ORX69982.1 - 4.3e-18 64.7 0.0 8e-18 63.9 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 ORX69982.1 - 6.6e-14 51.9 0.9 1.1e-10 41.4 1.5 2.4 2 0 0 2 2 2 2 Beta-lactamase superfamily domain MFS_1 PF07690.16 ORX69984.1 - 2.3e-32 112.3 67.2 7.8e-27 94.1 39.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69984.1 - 4.8 5.9 38.9 0.017 14.0 17.9 2.9 2 2 0 3 3 3 0 Sugar (and other) transporter Glyco_hydro_15 PF00723.21 ORX69985.1 - 1.4e-55 188.9 0.0 3.7e-51 174.3 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 tRNA_synthFbeta PF17759.1 ORX69986.1 - 1.1e-47 162.3 0.0 1.5e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 ORX69986.1 - 6e-30 103.3 0.5 1.3e-28 99.0 0.1 2.5 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 ORX69986.1 - 5e-24 84.9 0.1 8.4e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 ORX69986.1 - 8e-16 58.1 0.0 1.2e-13 51.1 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 ORX69986.1 - 0.0056 16.2 0.0 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) DUF2740 PF10872.8 ORX69986.1 - 0.087 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Acetyltransf_3 PF13302.7 ORX69987.1 - 3.8e-26 92.4 0.1 5.2e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ORX69987.1 - 1.2e-10 41.3 0.4 2.2e-10 40.4 0.4 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX69987.1 - 5.7e-10 39.5 0.0 9.8e-10 38.7 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ORX69987.1 - 0.0027 17.9 0.3 0.004 17.3 0.3 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX69987.1 - 0.0088 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX69987.1 - 0.037 14.0 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.7 ORX69987.1 - 0.05 14.0 0.0 0.075 13.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX69987.1 - 0.097 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF4211 PF13926.6 ORX69988.1 - 2.5e-25 89.2 0.0 6.3e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) MFS_1 PF07690.16 ORX69989.1 - 5.3e-35 121.0 41.7 1.7e-34 119.3 36.2 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69989.1 - 5.9e-13 48.5 9.5 5.9e-13 48.5 9.5 2.9 2 1 0 3 3 3 2 Sugar (and other) transporter EMC3_TMCO1 PF01956.16 ORX69989.1 - 0.12 12.1 1.3 0.19 11.4 0.2 1.9 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like MFS_1 PF07690.16 ORX69990.1 - 4.4e-38 131.1 47.4 1.3e-37 129.5 43.0 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX69990.1 - 7.7e-13 48.1 34.4 2.7e-11 43.0 15.1 2.9 2 1 0 2 2 2 2 Sugar (and other) transporter Adaptin_N PF01602.20 ORX69991.1 - 5.6e-119 398.1 0.0 6.9e-119 397.8 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 ORX69991.1 - 2.3e-52 177.1 0.5 4.9e-52 176.1 0.5 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ORX69991.1 - 5.9e-28 97.3 0.0 2e-27 95.6 0.0 2.0 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 ORX69991.1 - 1.5e-22 79.7 3.8 3.5e-11 43.3 0.4 5.5 4 2 1 5 5 5 4 HEAT repeats Cnd1 PF12717.7 ORX69991.1 - 1.7e-06 28.1 6.1 0.3 11.1 0.3 4.5 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX69991.1 - 3.7e-06 27.3 9.5 8.6e-05 23.0 2.7 3.9 3 1 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 ORX69991.1 - 1.2e-05 25.1 18.4 0.32 11.4 0.6 7.2 8 1 1 9 9 9 2 HEAT repeat HEAT_PBS PF03130.16 ORX69991.1 - 0.0002 21.7 10.0 1.5 9.7 0.2 6.6 7 0 0 7 7 7 2 PBS lyase HEAT-like repeat Arm PF00514.23 ORX69991.1 - 0.0039 17.2 3.1 2.4 8.4 0.0 4.8 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Cu-oxidase_2 PF07731.14 ORX69992.1 - 2.2e-37 127.9 0.8 5.2e-34 116.9 0.1 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX69992.1 - 3.2e-28 98.9 0.0 1.7e-23 83.5 0.1 3.3 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX69992.1 - 6.3e-12 45.5 1.0 8.2e-10 38.7 0.0 3.4 3 1 1 4 4 4 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ORX69992.1 - 0.16 12.1 0.0 7.8 6.7 0.0 3.0 3 1 0 3 3 3 0 Cupredoxin-like domain Transferase PF02458.15 ORX69993.1 - 2.7e-27 95.5 0.0 1.2e-14 53.8 0.0 2.1 2 0 0 2 2 2 2 Transferase family Transferase PF02458.15 ORX69994.1 - 1.8e-24 86.2 0.0 1.3e-13 50.4 0.1 2.3 2 1 0 2 2 2 2 Transferase family Aminotran_1_2 PF00155.21 ORX69995.1 - 5.8e-65 219.8 0.0 6.8e-65 219.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ORX69995.1 - 1.9e-06 27.1 0.0 5.3e-06 25.6 0.0 1.6 1 1 1 2 2 2 1 Aminotransferase class-V SHMT PF00464.19 ORX69995.1 - 0.00024 19.8 0.0 0.0041 15.8 0.0 2.3 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Pyridoxal_deC PF00282.19 ORX69995.1 - 0.0064 15.3 0.0 0.0086 14.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain OKR_DC_1 PF01276.20 ORX69995.1 - 0.027 13.2 0.1 0.22 10.2 0.1 2.1 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Acyl-CoA_dh_2 PF08028.11 ORX69995.1 - 0.03 14.6 0.3 0.51 10.6 0.3 2.2 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Epimerase PF01370.21 ORX69996.1 - 6.1e-28 97.9 0.0 9.5e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX69996.1 - 1.5e-16 60.7 0.0 2.6e-16 60.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ORX69996.1 - 1.4e-10 40.7 0.0 2.2e-10 40.1 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ORX69996.1 - 3.4e-09 36.1 0.0 1.1e-08 34.4 0.0 1.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ORX69996.1 - 5.8e-07 28.9 0.0 2.4e-05 23.7 0.0 2.4 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ORX69996.1 - 0.00013 21.3 0.0 0.00071 18.8 0.0 2.2 2 1 0 2 2 2 1 Male sterility protein KR PF08659.10 ORX69996.1 - 0.17 11.7 0.1 2.5 8.0 0.0 2.2 1 1 1 2 2 2 0 KR domain Glyco_hydro_125 PF06824.11 ORX69997.1 - 1.6e-158 528.0 0.0 1.9e-158 527.8 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Homeobox_KN PF05920.11 ORX69998.1 - 1e-05 25.3 3.3 2.1e-05 24.3 3.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Glyco_hydro_20 PF00728.22 ORX69999.1 - 9.6e-103 344.3 0.7 1.3e-102 343.8 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX69999.1 - 2.5e-17 63.8 0.1 9.6e-17 61.9 0.0 2.0 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX69999.1 - 6.7e-06 26.9 0.0 1.6e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 ORX70000.1 - 9.1e-103 344.3 0.6 1.3e-102 343.9 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70000.1 - 2.3e-17 63.9 0.1 9.5e-17 61.9 0.0 2.1 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX70000.1 - 4.7e-06 27.4 0.1 5.4e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 ORX70001.1 - 9.2e-104 347.6 1.0 1.2e-103 347.3 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70001.1 - 4e-17 63.1 0.0 2.5e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX70001.1 - 0.00018 22.3 0.5 0.00052 20.8 0.1 2.1 2 1 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 ORX70002.1 - 2.3e-97 326.6 3.5 2.8e-97 326.3 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70002.1 - 6.8e-16 59.2 0.0 1.4e-15 58.1 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX70002.1 - 8e-06 26.7 0.1 5.7e-05 23.9 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 Glyco_hydro_20 PF00728.22 ORX70003.1 - 9.5e-104 347.6 3.6 1.1e-103 347.3 3.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70003.1 - 9.5e-05 23.1 0.0 0.00024 21.8 0.0 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like WAPL PF07814.13 ORX70004.1 - 0.019 13.8 9.1 0.064 12.0 6.1 2.5 1 1 2 3 3 3 0 Wings apart-like protein regulation of heterochromatin Tau95_N PF17682.1 ORX70005.1 - 9.9e-27 93.6 0.0 9.9e-27 93.6 0.0 1.8 2 0 0 2 2 2 1 Tau95 Triple barrel domain Tau95 PF09734.9 ORX70005.1 - 3.5e-22 79.7 0.7 3.5e-22 79.7 0.7 1.8 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain ATPgrasp_Ter PF15632.6 ORX70005.1 - 0.14 11.9 0.3 12 5.6 0.1 2.3 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon HMG_box PF00505.19 ORX70006.1 - 1.2e-13 51.2 3.0 2.6e-13 50.2 3.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX70006.1 - 7.5e-12 45.7 5.8 1.8e-11 44.5 5.8 1.6 1 0 0 1 1 1 1 HMG-box domain PhoH PF02562.16 ORX70008.1 - 0.0032 17.0 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 ORX70008.1 - 0.074 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 ORX70008.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NACHT PF05729.12 ORX70008.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DAP3 PF10236.9 ORX70008.1 - 0.16 11.1 0.0 0.37 9.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Bac_DnaA PF00308.18 ORX70008.1 - 0.16 11.8 0.2 0.52 10.1 0.0 1.8 2 0 0 2 2 2 0 Bacterial dnaA protein LMBR1 PF04791.16 ORX70009.1 - 0.026 13.5 0.0 0.075 11.9 0.0 1.7 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIA PF03153.13 ORX70009.1 - 5.8 6.8 15.0 11 5.9 15.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peroxin-13_N PF04088.13 ORX70010.1 - 1.6e-37 129.0 0.6 2.8e-37 128.2 0.6 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 ORX70010.1 - 1.4e-13 50.3 0.1 2.4e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX70010.1 - 6.3e-13 48.4 0.1 9.5e-13 47.8 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX70010.1 - 3.9e-12 45.6 0.2 7.1e-12 44.7 0.2 1.5 1 0 0 1 1 1 1 SH3 domain Pex2_Pex12 PF04757.14 ORX70010.1 - 0.019 14.6 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region Mis12 PF05859.12 ORX70011.1 - 1.1e-32 113.0 0.2 1.1e-32 113.0 0.2 1.7 2 0 0 2 2 2 1 Mis12 protein V-SNARE PF05008.15 ORX70011.1 - 0.038 14.4 0.7 0.26 11.7 0.1 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF1690 PF07956.11 ORX70011.1 - 0.35 11.3 1.8 0.4 11.1 0.5 1.7 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) PX PF00787.24 ORX70012.1 - 5.2e-14 52.2 0.0 9.2e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 PX domain BMFP PF04380.13 ORX70012.1 - 0.43 11.1 3.1 1.1 9.8 0.5 2.4 2 0 0 2 2 2 0 Membrane fusogenic activity Kin17_mid PF10357.9 ORX70013.1 - 8.7e-52 174.3 2.8 1.1e-51 174.0 2.8 1.1 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 ORX70013.1 - 0.081 13.2 8.4 0.14 12.5 8.4 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding FMP23 PF17315.2 ORX70013.1 - 0.1 12.8 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Found in mitochondrial proteome zf-met PF12874.7 ORX70013.1 - 0.16 12.4 8.8 0.3 11.5 8.8 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Zn_clus PF00172.18 ORX70015.1 - 1.6e-09 37.7 7.4 3.8e-09 36.5 7.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX70015.1 - 6.5e-06 25.4 0.1 1.2e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ArfGap PF01412.18 ORX70016.1 - 1.2e-31 109.2 0.1 2.4e-31 108.2 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Scm3 PF10384.9 ORX70017.1 - 3.8e-14 52.2 0.2 3.8e-14 52.2 0.2 2.0 2 0 0 2 2 2 1 Centromere protein Scm3 CRAL_TRIO PF00650.20 ORX70018.1 - 3.1e-17 62.7 0.0 4.7e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX70018.1 - 0.0053 16.9 0.1 0.043 14.0 0.0 2.6 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX70018.1 - 0.023 14.9 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Scm3 PF10384.9 ORX70018.1 - 0.15 11.9 0.1 0.4 10.4 0.1 1.7 1 0 0 1 1 1 0 Centromere protein Scm3 Med27 PF11571.8 ORX70019.1 - 3.5e-13 49.7 0.1 1.1e-12 48.2 0.1 1.8 1 0 0 1 1 1 1 Mediator complex subunit 27 IL11 PF07400.11 ORX70019.1 - 0.015 15.0 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Interleukin 11 FUSC PF04632.12 ORX70019.1 - 0.015 13.8 1.2 0.02 13.5 1.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family alpha-hel2 PF14456.6 ORX70019.1 - 0.026 13.8 0.0 0.068 12.5 0.0 1.6 1 1 0 1 1 1 0 Alpha-helical domain 2 Baculo_PEP_C PF04513.12 ORX70019.1 - 0.034 14.2 0.0 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HAMP PF00672.25 ORX70019.1 - 0.053 13.9 0.2 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 HAMP domain RITA PF17066.5 ORX70019.1 - 0.066 12.8 0.2 0.098 12.2 0.2 1.2 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein Seryl_tRNA_N PF02403.22 ORX70019.1 - 0.13 12.5 0.0 0.55 10.5 0.0 1.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain WXG100 PF06013.12 ORX70019.1 - 0.15 12.3 0.1 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Pkinase PF00069.25 ORX70020.1 - 1.5e-71 240.8 0.0 1.7e-71 240.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70020.1 - 2.4e-42 145.0 0.0 2.9e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX70020.1 - 3.3e-05 23.9 0.0 5.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX70020.1 - 0.00014 21.5 0.1 0.0002 21.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ORX70020.1 - 0.00025 20.1 0.5 0.00034 19.7 0.5 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX70020.1 - 0.00096 18.5 0.0 0.014 14.8 0.0 2.3 2 1 0 2 2 2 1 Kinase-like SMC_Nse1 PF07574.13 ORX70020.1 - 0.0092 15.9 0.0 0.023 14.6 0.0 1.6 2 0 0 2 2 2 1 Nse1 non-SMC component of SMC5-6 complex Choline_kinase PF01633.20 ORX70020.1 - 0.024 14.2 0.5 0.057 13.0 0.3 1.6 1 1 1 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX70020.1 - 0.068 12.5 0.4 0.1 11.9 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX70020.1 - 0.093 12.3 0.1 11 5.5 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RRM_1 PF00076.22 ORX70021.1 - 7.7e-16 57.7 0.1 4.2e-07 29.7 0.1 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX70021.1 - 0.00041 20.3 0.0 0.0054 16.7 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ORX70021.1 - 0.011 15.8 0.0 0.052 13.7 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 ORX70021.1 - 0.16 12.2 2.2 17 5.6 0.0 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF1639 PF07797.14 ORX70021.1 - 0.29 11.1 1.9 0.5 10.4 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) Nnf1 PF03980.14 ORX70022.1 - 6.9e-18 65.0 2.3 1.3e-17 64.2 2.3 1.4 1 0 0 1 1 1 1 Nnf1 DUF4407 PF14362.6 ORX70022.1 - 0.00033 20.1 2.8 0.00041 19.8 2.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) GlutR_dimer PF00745.20 ORX70022.1 - 0.034 14.6 4.7 0.045 14.2 3.2 2.0 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain KfrA_N PF11740.8 ORX70022.1 - 0.035 14.8 10.4 8 7.2 10.6 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Bacillus_HBL PF05791.11 ORX70022.1 - 0.12 12.2 2.1 0.35 10.7 0.8 2.0 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) YqjK PF13997.6 ORX70022.1 - 0.43 10.9 2.6 0.6 10.4 0.5 2.2 3 0 0 3 3 3 0 YqjK-like protein DUF5595 PF18077.1 ORX70022.1 - 1 9.5 5.3 3.6 7.7 3.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5595) Pro_isomerase PF00160.21 ORX70023.1 - 1.6e-48 165.0 0.4 1.1e-47 162.3 0.1 2.2 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 ORX70023.1 - 1.2e-08 35.4 0.8 0.025 15.4 0.0 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70023.1 - 0.028 14.7 0.0 17 5.8 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain PPR_2 PF13041.6 ORX70024.1 - 5.5e-25 87.3 0.0 2.7e-08 33.9 0.0 7.7 7 1 1 8 8 8 4 PPR repeat family PPR_3 PF13812.6 ORX70024.1 - 2e-22 79.0 0.3 1.9e-09 37.4 0.1 6.3 5 1 1 6 6 6 4 Pentatricopeptide repeat domain PPR PF01535.20 ORX70024.1 - 1.7e-20 71.7 12.2 0.03 14.6 0.0 10.8 12 0 0 12 12 12 6 PPR repeat PPR_1 PF12854.7 ORX70024.1 - 1.8e-14 53.2 0.1 0.00014 21.5 0.1 5.5 6 0 0 6 6 6 3 PPR repeat PPR_long PF17177.4 ORX70024.1 - 3.7e-09 36.3 0.2 0.0057 16.0 0.0 4.1 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 ORX70024.1 - 0.0017 17.3 0.5 0.05 12.5 0.0 2.7 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S27 Iso_dh PF00180.20 ORX70025.1 - 1.2e-115 386.4 0.0 1.7e-115 385.9 0.0 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aconitase PF00330.20 ORX70025.1 - 1e-68 232.5 0.1 5.9e-67 226.6 0.1 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX70025.1 - 1.2e-12 48.3 0.0 2.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Bromodomain PF00439.25 ORX70026.1 - 2.9e-25 88.2 0.0 3.3e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Tubulin PF00091.25 ORX70027.1 - 6.4e-68 228.8 0.0 1e-67 228.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX70027.1 - 1.3e-41 141.7 0.0 2e-41 141.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX70027.1 - 6.2e-05 23.3 0.0 0.00015 22.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ORX70027.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 ORX70027.1 - 0.026 14.2 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain BOFC_N PF08977.10 ORX70027.1 - 0.38 10.8 3.5 19 5.3 0.0 2.5 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal Sec10 PF07393.11 ORX70028.1 - 1.4e-153 513.0 0.0 1.3e-77 261.8 0.3 2.1 1 1 1 2 2 2 2 Exocyst complex component Sec10 Snapin_Pallidin PF14712.6 ORX70028.1 - 0.011 16.1 0.3 0.12 12.8 0.1 2.7 2 1 0 2 2 2 0 Snapin/Pallidin Spc7 PF08317.11 ORX70028.1 - 0.015 14.2 0.8 0.048 12.5 0.4 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein UNC45-central PF11701.8 ORX70028.1 - 0.018 15.0 0.3 0.94 9.4 0.0 3.4 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central Fungal_TACC PF12709.7 ORX70028.1 - 0.045 14.2 2.8 0.089 13.2 0.0 2.8 3 1 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins COG7 PF10191.9 ORX70028.1 - 0.051 11.8 2.1 0.039 12.2 0.4 1.6 2 1 0 2 2 2 0 Golgi complex component 7 (COG7) CTD_bind PF04818.13 ORX70028.1 - 0.078 13.8 0.8 14 6.6 0.0 3.5 3 0 0 3 3 3 0 RNA polymerase II-binding domain. CDH1_2_SANT_HL1 PF18375.1 ORX70028.1 - 0.12 13.1 0.0 7.9 7.2 0.0 3.3 3 0 0 3 3 2 0 CDH1/2 SANT-Helical linker 1 Nsp1_C PF05064.13 ORX70028.1 - 0.19 11.6 2.7 4.2 7.2 0.1 2.9 2 1 1 3 3 3 0 Nsp1-like C-terminal region Co_AT_N PF12557.8 ORX70028.1 - 0.21 11.5 1.1 0.58 10.1 1.1 1.7 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal DUF5344 PF17279.2 ORX70028.1 - 0.79 10.3 2.8 1.3 9.7 0.0 2.9 3 1 1 4 4 3 0 Family of unknown function (DUF5344) PI31_Prot_C PF08577.11 ORX70029.1 - 6.2e-11 43.3 6.1 6.2e-11 43.3 6.1 3.1 3 1 0 3 3 3 1 PI31 proteasome regulator PI31_Prot_N PF11566.8 ORX70029.1 - 0.04 13.7 0.0 0.055 13.3 0.0 1.1 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal Transket_pyr PF02779.24 ORX70030.1 - 8.3e-64 214.5 0.0 1.6e-63 213.6 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ORX70030.1 - 1.3e-62 211.5 0.0 1.8e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ORX70030.1 - 3.6e-48 163.1 0.0 5.7e-48 162.5 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ORX70030.1 - 9.1e-19 66.8 0.4 9.1e-19 66.8 0.4 1.9 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GIY-YIG PF01541.24 ORX70031.1 - 7e-14 51.9 0.0 1.1e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 GIY-YIG catalytic domain Prok-RING_1 PF14446.6 ORX70031.1 - 0.016 15.1 1.8 0.016 15.1 1.8 2.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DUF2677 PF10838.8 ORX70031.1 - 0.076 13.0 0.7 0.16 11.9 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) RhoGEF PF00621.20 ORX70034.1 - 7.2e-46 156.7 0.0 1.1e-45 156.2 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 ORX70034.1 - 2.9e-24 85.0 28.5 5.2e-18 64.9 8.9 3.0 3 0 0 3 3 3 2 FYVE zinc finger FYVE_2 PF02318.16 ORX70034.1 - 1.7e-07 31.5 17.6 0.0019 18.4 2.3 2.6 2 0 0 2 2 2 2 FYVE-type zinc finger PH PF00169.29 ORX70034.1 - 1.9e-05 25.1 0.0 3.4e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 PH domain Ribosomal_L7Ae PF01248.26 ORX70035.1 - 7.6e-23 80.1 0.0 8.7e-23 79.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PWWP PF00855.17 ORX70036.1 - 1.5e-20 73.3 0.1 4e-20 72.0 0.1 1.7 1 0 0 1 1 1 1 PWWP domain Med26 PF08711.11 ORX70036.1 - 0.00057 19.8 0.1 0.0014 18.6 0.1 1.7 1 1 0 1 1 1 1 TFIIS helical bundle-like domain SLC12 PF03522.15 ORX70036.1 - 0.49 9.3 4.5 0.74 8.8 4.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PI3K_1B_p101 PF10486.9 ORX70036.1 - 4 5.1 12.0 5 4.8 12.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Menin PF05053.13 ORX70036.1 - 5.6 5.2 15.3 8.3 4.6 15.3 1.2 1 0 0 1 1 1 0 Menin Rad60-SLD PF11976.8 ORX70037.1 - 3.7e-20 71.5 0.0 4.7e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX70037.1 - 5.8e-09 35.6 0.0 6.8e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.12 ORX70037.1 - 0.062 13.7 0.0 0.079 13.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) tRNA-synt_1d PF00750.19 ORX70038.1 - 2e-104 349.3 1.8 2.6e-104 348.9 1.8 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ORX70038.1 - 4.9e-25 88.0 0.0 1.2e-24 86.8 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 ORX70038.1 - 5.8e-08 33.2 0.0 1.4e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain His_Phos_1 PF00300.22 ORX70039.1 - 6.9e-40 136.8 0.2 2.2e-39 135.2 0.1 1.7 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Septin PF00735.18 ORX70040.1 - 5.4e-113 376.9 0.3 7.5e-113 376.5 0.3 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX70040.1 - 3.3e-07 30.4 0.0 7.3e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX70040.1 - 2.1e-05 24.2 3.2 0.00031 20.3 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX70040.1 - 0.00011 22.1 0.8 0.0013 18.6 0.4 2.6 2 1 0 2 2 2 1 RsgA GTPase Roc PF08477.13 ORX70040.1 - 0.00069 19.8 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 ORX70040.1 - 0.002 17.5 0.0 0.0054 16.1 0.0 1.8 1 0 0 1 1 1 1 AIG1 family AAA_24 PF13479.6 ORX70040.1 - 0.005 16.6 0.6 0.013 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX70040.1 - 0.0075 16.5 0.1 0.025 14.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain Spore_IV_A PF09547.10 ORX70040.1 - 0.011 14.7 0.0 0.02 13.8 0.0 1.3 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Microtub_bd PF16796.5 ORX70040.1 - 0.017 15.0 0.1 0.044 13.7 0.1 1.6 1 0 0 1 1 1 0 Microtubule binding Ras PF00071.22 ORX70040.1 - 0.019 14.5 0.1 0.051 13.2 0.1 1.7 1 1 0 1 1 1 0 Ras family AAA_7 PF12775.7 ORX70040.1 - 0.021 14.4 0.1 0.049 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ORX70040.1 - 0.029 14.9 0.3 0.17 12.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ORX70040.1 - 0.033 14.6 0.2 0.67 10.4 0.0 2.7 2 1 1 3 3 3 0 RNA helicase Pox_A32 PF04665.12 ORX70040.1 - 0.034 13.6 0.2 0.079 12.4 0.2 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein FtsK_SpoIIIE PF01580.18 ORX70040.1 - 0.082 12.3 1.3 0.37 10.1 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 ORX70040.1 - 0.085 12.9 6.1 0.72 9.9 0.1 3.1 2 1 1 3 3 3 0 Dynamin family AAA_16 PF13191.6 ORX70040.1 - 0.15 12.4 0.5 0.47 10.8 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain DUF3987 PF13148.6 ORX70040.1 - 0.44 9.5 3.5 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) rRNA_processing PF08524.11 ORX70041.1 - 7.2e-11 42.3 37.4 1.4e-09 38.1 37.4 2.2 1 1 0 1 1 1 1 rRNA processing CDC45 PF02724.14 ORX70041.1 - 0.3 9.3 17.4 0.39 8.9 17.4 1.2 1 0 0 1 1 1 0 CDC45-like protein E7 PF00527.18 ORX70041.1 - 3.8 7.8 6.1 1.4 9.2 1.5 2.2 2 0 0 2 2 2 0 E7 protein, Early protein LRR_8 PF13855.6 ORX70042.1 - 2e-17 62.7 6.4 7.7e-08 32.0 0.2 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ORX70042.1 - 7.1e-16 58.1 4.4 2.1e-05 24.8 0.1 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX70042.1 - 8.9e-08 31.7 1.2 18 6.4 0.0 6.2 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.6 ORX70042.1 - 0.2 11.8 7.6 8.9 6.7 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat Ribosomal_S8e PF01201.22 ORX70043.1 - 2.2e-51 173.7 2.0 5.4e-51 172.4 2.0 1.7 1 1 0 1 1 1 1 Ribosomal protein S8e DUF4078 PF13300.6 ORX70044.1 - 3.4e-07 30.5 0.1 3.4e-07 30.5 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) TAF4 PF05236.14 ORX70045.1 - 1.9e-23 83.6 0.0 1.9e-23 83.6 0.0 5.1 5 1 0 5 5 5 1 Transcription initiation factor TFIID component TAF4 family YEATS PF03366.16 ORX70046.1 - 7.9e-20 70.6 0.2 1.4e-19 69.8 0.2 1.4 1 0 0 1 1 1 1 YEATS family CPSF100_C PF13299.6 ORX70046.1 - 0.028 14.6 6.0 2.3 8.4 0.4 3.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RGS PF00615.19 ORX70047.1 - 1.5e-06 28.4 0.2 0.0005 20.3 0.0 2.5 3 0 0 3 3 3 2 Regulator of G protein signaling domain DC_STAMP PF07782.13 ORX70047.1 - 5 6.9 6.7 3.8 7.3 0.1 2.9 3 0 0 3 3 3 0 DC-STAMP-like protein HAD_2 PF13419.6 ORX70048.1 - 2.7e-24 86.2 0.0 3.3e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX70048.1 - 2.6e-15 57.3 0.1 4.4e-13 50.0 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX70048.1 - 8e-05 22.6 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ORX70048.1 - 0.0064 16.6 0.0 0.45 10.7 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX70048.1 - 0.012 16.0 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase APH PF01636.23 ORX70048.1 - 0.062 13.2 0.0 4.4 7.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family ATP-synt_F PF01990.17 ORX70049.1 - 3e-33 114.0 0.4 3.6e-33 113.7 0.4 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DEK_C PF08766.11 ORX70049.1 - 0.026 14.5 0.6 0.091 12.7 0.2 1.9 2 0 0 2 2 2 0 DEK C terminal domain DAHP_snth_FXD PF18152.1 ORX70049.1 - 0.12 12.3 1.2 1.3 8.9 0.1 2.3 2 0 0 2 2 2 0 DAHP synthase ferredoxin-like domain TIP49 PF06068.13 ORX70050.1 - 1.6e-168 560.4 0.1 2e-168 560.1 0.1 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ORX70050.1 - 1.3e-20 73.2 0.1 4.5e-20 71.6 0.0 2.0 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 ORX70050.1 - 6.9e-10 39.5 0.1 5.9e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX70050.1 - 3e-08 33.6 0.0 5.3e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX70050.1 - 4.6e-05 23.9 0.0 0.00059 20.3 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX70050.1 - 5.7e-05 23.4 0.1 0.1 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 ORX70050.1 - 0.00062 19.5 0.0 0.67 9.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 ORX70050.1 - 0.00089 19.3 0.0 0.55 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ORX70050.1 - 0.0014 18.6 0.0 0.27 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX70050.1 - 0.0017 17.7 0.1 0.0053 16.1 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 ORX70050.1 - 0.0033 16.8 0.0 0.15 11.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ORX70050.1 - 0.0081 16.5 1.2 0.25 11.7 1.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX70050.1 - 0.0082 16.7 0.0 0.023 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX70050.1 - 0.015 15.7 0.6 0.34 11.3 0.0 3.0 4 0 0 4 4 3 0 AAA domain AAA_25 PF13481.6 ORX70050.1 - 0.02 14.5 0.1 0.086 12.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ORX70050.1 - 0.021 14.1 0.0 0.043 13.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 ORX70050.1 - 0.026 14.5 0.0 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ORX70050.1 - 0.032 14.8 0.1 0.083 13.4 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 ORX70050.1 - 0.034 13.9 0.0 0.082 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 ORX70050.1 - 0.036 14.3 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ORX70050.1 - 0.045 13.9 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.18 ORX70050.1 - 0.09 12.1 0.1 0.37 10.1 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family SMC_N PF02463.19 ORX70050.1 - 0.16 11.4 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Cyt-b5 PF00173.28 ORX70051.1 - 4.6e-13 49.1 0.1 5.2e-13 48.9 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MIP PF00230.20 ORX70052.1 - 2.1e-45 155.2 11.8 2.9e-45 154.8 11.8 1.2 1 0 0 1 1 1 1 Major intrinsic protein FA_desaturase PF00487.24 ORX70053.1 - 4e-18 66.2 26.4 4.4e-18 66.0 25.2 1.6 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 ORX70053.1 - 2.6e-16 59.5 0.1 6.6e-16 58.2 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 ORX70053.1 - 0.0043 17.4 12.6 0.14 12.5 3.7 2.5 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily FA_desaturase PF00487.24 ORX70054.1 - 2.7e-19 70.0 17.6 5.1e-19 69.1 17.6 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ORX70054.1 - 1.3e-16 60.5 0.1 3.1e-16 59.3 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 ORX70054.1 - 0.0087 16.4 11.0 0.74 10.2 0.6 2.5 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Cu-oxidase_2 PF07731.14 ORX70055.1 - 5.8e-36 123.3 1.8 5.4e-31 107.1 0.0 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX70055.1 - 2.5e-28 98.5 1.9 1.6e-27 95.8 0.2 2.9 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX70055.1 - 4.3e-24 85.4 0.1 2.3e-21 76.6 0.0 2.6 3 0 0 3 3 3 2 Multicopper oxidase bZIP_1 PF00170.21 ORX70057.1 - 4.9e-07 29.7 9.6 1.5e-06 28.2 9.6 1.8 1 1 0 1 1 1 1 bZIP transcription factor TolA_bind_tri PF16331.5 ORX70057.1 - 0.0031 17.5 1.4 0.0076 16.3 1.4 1.6 1 0 0 1 1 1 1 TolA binding protein trimerisation SlyX PF04102.12 ORX70057.1 - 0.029 15.0 0.1 0.14 12.8 0.0 2.2 2 0 0 2 2 2 0 SlyX FAM199X PF15814.5 ORX70057.1 - 1.2 8.1 10.2 2.4 7.1 10.2 1.4 1 0 0 1 1 1 0 Protein family FAM199X bZIP_2 PF07716.15 ORX70057.1 - 8.5 6.5 13.9 1.5 9.0 0.6 2.4 1 1 1 2 2 2 0 Basic region leucine zipper tRNA-synt_1 PF00133.22 ORX70058.1 - 1.2e-218 727.2 0.0 1.5e-217 723.6 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX70058.1 - 8.2e-40 136.2 0.1 1.7e-39 135.2 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX70058.1 - 7.7e-14 51.2 0.1 1.9e-06 26.9 0.0 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ORX70058.1 - 5.4e-12 45.6 0.1 5.4e-09 35.8 0.0 2.8 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 ORX70058.1 - 6.9e-06 26.3 0.9 6.9e-06 26.3 0.9 2.6 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.25 ORX70058.1 - 0.011 15.0 0.0 0.89 8.8 0.0 2.8 2 1 1 3 3 3 0 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.19 ORX70058.1 - 0.019 14.3 0.0 0.075 12.4 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Remorin_C PF03763.13 ORX70058.1 - 2.9 7.8 22.0 4.8 7.1 0.1 3.3 3 0 0 3 3 3 0 Remorin, C-terminal region Aldo_ket_red PF00248.21 ORX70059.1 - 1.6e-47 162.1 0.0 6.3e-46 156.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 ORX70060.1 - 2.1e-46 158.4 0.0 8.6e-45 153.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Pkinase_fungal PF17667.1 ORX70062.1 - 2.3e-60 204.5 0.8 7.4e-36 123.8 0.3 2.5 2 1 1 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX70062.1 - 5.2e-07 29.3 0.2 2.4e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70062.1 - 0.00065 19.1 0.9 0.0054 16.1 0.9 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ORX70062.1 - 0.0029 17.2 0.1 0.0054 16.3 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ORX70062.1 - 0.0035 16.7 0.0 0.0066 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX70062.1 - 0.016 15.2 0.1 0.042 13.8 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX70062.1 - 0.073 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase E1-E2_ATPase PF00122.20 ORX70064.1 - 9.4e-52 175.2 0.4 9.4e-52 175.2 0.4 2.5 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX70064.1 - 1.8e-42 146.0 0.7 7.6e-42 144.0 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX70064.1 - 3.2e-25 88.4 0.0 8e-12 45.4 0.0 2.5 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ORX70064.1 - 7.5e-07 29.7 0.0 1.9e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX70064.1 - 6.9e-06 26.0 0.8 0.0061 16.3 0.4 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase EccE PF11203.8 ORX70064.1 - 3.2 8.1 7.5 5.5 7.4 0.0 4.0 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE p450 PF00067.22 ORX70066.1 - 2.8e-68 230.8 0.0 3.7e-68 230.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 XRN_N PF03159.18 ORX70068.1 - 6.7e-95 317.1 0.0 7.6e-95 316.9 0.0 1.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus SNAP PF14938.6 ORX70069.1 - 2e-105 352.3 23.3 2.3e-105 352.1 23.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Spatacsin_C PF14649.6 ORX70069.1 - 0.0011 18.2 13.4 0.052 12.7 12.8 2.5 1 1 1 2 2 2 1 Spatacsin C-terminus DHR-2 PF06920.13 ORX70069.1 - 0.0042 15.8 2.4 0.0098 14.6 1.8 1.9 1 1 0 1 1 1 1 Dock homology region 2 TPR_12 PF13424.6 ORX70069.1 - 0.11 12.8 22.4 0.83 10.0 0.7 4.3 1 1 3 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ORX70069.1 - 1.1 9.4 15.7 0.81 9.8 3.8 4.3 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 ORX70069.1 - 1.2 9.4 20.9 4.1 7.7 0.2 6.0 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX70069.1 - 1.7 9.1 22.1 0.92 9.9 0.9 5.4 5 1 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX70069.1 - 1.9 8.7 16.4 3.5 7.9 0.1 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX70069.1 - 2.9 8.7 24.8 21 6.1 0.1 6.2 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX70069.1 - 4.3 7.3 15.0 22 5.1 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX70069.1 - 4.8 7.5 14.8 0.32 11.2 2.3 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-rbx1 PF12678.7 ORX70070.1 - 4.7e-24 84.4 12.9 6.6e-24 84.0 12.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX70070.1 - 1.9e-18 66.3 8.6 2.5e-18 65.9 8.6 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 ORX70070.1 - 8.5e-07 29.2 13.9 4.9e-05 23.6 14.0 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX70070.1 - 0.00014 21.6 6.0 0.00014 21.6 6.0 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX70070.1 - 0.0012 18.6 12.6 0.024 14.5 12.6 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX70070.1 - 0.083 12.8 11.4 0.3 11.0 5.7 2.5 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX70070.1 - 0.26 11.4 7.7 1.1 9.4 7.7 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 ORX70070.1 - 0.51 10.1 14.6 12 5.7 14.6 2.4 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 ORX70070.1 - 0.65 9.7 13.8 0.078 12.6 4.5 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ORX70070.1 - 2.3 8.4 11.3 5 7.4 11.3 1.5 1 1 0 1 1 1 0 FANCL C-terminal domain DEAD PF00270.29 ORX70071.1 - 3.5e-49 166.9 0.0 1.5e-48 164.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX70071.1 - 1.9e-27 95.8 0.6 4.9e-27 94.5 0.2 2.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX70071.1 - 0.0014 18.7 0.0 0.0046 17.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ORX70071.1 - 0.0056 17.0 0.0 1.8 8.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX70071.1 - 0.19 12.0 2.2 1.6 9.0 0.1 3.1 2 1 1 3 3 3 0 AAA domain CAP_GLY PF01302.25 ORX70072.1 - 4.3e-19 68.3 0.1 7.9e-19 67.4 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 ORX70072.1 - 9.9e-08 31.7 20.7 9.9e-05 22.1 5.6 2.4 2 0 0 2 2 2 2 CLIP1 zinc knuckle FlxA PF14282.6 ORX70072.1 - 0.0062 16.5 6.8 0.0062 16.5 6.8 6.8 3 3 3 6 6 5 1 FlxA-like protein DUF4200 PF13863.6 ORX70072.1 - 0.0063 16.9 7.9 0.0063 16.9 7.9 6.7 3 2 2 5 5 4 1 Domain of unknown function (DUF4200) ATG16 PF08614.11 ORX70072.1 - 0.011 15.9 73.8 0.19 11.9 7.7 6.0 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) eIF3g PF12353.8 ORX70072.1 - 0.014 15.7 1.2 0.014 15.7 1.2 3.1 3 1 1 4 4 2 0 Eukaryotic translation initiation factor 3 subunit G NuDC PF16273.5 ORX70072.1 - 0.18 12.4 0.2 0.18 12.4 0.2 5.5 6 2 1 7 7 5 0 Nuclear distribution C domain Fez1 PF06818.15 ORX70072.1 - 0.23 11.9 58.3 0.033 14.6 17.7 5.0 2 2 4 6 6 6 0 Fez1 DUF2313 PF10076.9 ORX70072.1 - 0.34 10.8 4.2 0.17 11.8 1.0 2.2 2 0 0 2 2 1 0 Uncharacterised protein conserved in bacteria (DUF2313) Spc7 PF08317.11 ORX70072.1 - 0.45 9.4 66.2 0.0075 15.2 18.2 4.6 1 1 5 6 6 6 0 Spc7 kinetochore protein APG6_N PF17675.1 ORX70072.1 - 0.64 10.5 77.2 1.3 9.6 11.1 5.5 3 2 2 5 5 5 0 Apg6 coiled-coil region DUF812 PF05667.11 ORX70072.1 - 0.93 8.3 54.7 0.092 11.6 20.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF812) YabA PF06156.13 ORX70072.1 - 1.3 9.7 40.5 1.5 9.5 0.3 7.2 2 2 6 8 8 8 0 Initiation control protein YabA zf-CCHC_2 PF13696.6 ORX70072.1 - 1.5 8.7 8.6 0.32 10.8 0.9 2.4 2 0 0 2 2 2 0 Zinc knuckle Sec34 PF04136.15 ORX70072.1 - 1.7 8.5 30.0 0.29 11.0 0.1 5.2 3 1 2 5 5 5 0 Sec34-like family TSC22 PF01166.18 ORX70072.1 - 1.9 8.9 33.9 8.7 6.7 0.1 8.1 9 0 0 9 9 8 0 TSC-22/dip/bun family DUF4407 PF14362.6 ORX70072.1 - 2.5 7.4 56.5 2.5 7.4 15.3 5.0 2 2 3 5 5 5 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 ORX70072.1 - 3.9 8.0 0.0 3.9 8.0 0.0 7.3 4 3 4 8 8 7 0 Nucleopolyhedrovirus P10 protein MRFAP1 PF15155.6 ORX70072.1 - 4.4 7.9 22.8 0.3 11.6 0.4 4.9 4 2 1 6 6 5 0 MORF4 family-associated protein1 Prominin PF05478.11 ORX70072.1 - 4.7 5.0 33.9 0.0099 13.9 13.9 2.8 2 1 0 2 2 2 0 Prominin PARP_reg PF02877.14 ORX70072.1 - 6.2 6.9 9.1 0.81 9.8 3.1 2.6 2 1 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain zf-CCHC PF00098.23 ORX70072.1 - 9.4 6.5 9.4 1.9 8.7 1.3 2.6 2 0 0 2 2 2 0 Zinc knuckle SNARE_assoc PF09335.11 ORX70073.1 - 1.5e-10 41.6 1.3 1.5e-10 41.6 1.3 2.5 3 1 0 3 3 3 1 SNARE associated Golgi protein Pkinase PF00069.25 ORX70074.1 - 2.9e-71 239.9 0.0 3.3e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70074.1 - 1.5e-52 178.4 0.0 1.9e-52 178.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX70074.1 - 4.7e-08 32.7 0.0 0.008 15.5 0.0 2.4 2 1 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX70074.1 - 6.5e-05 22.6 0.0 0.00014 21.5 0.0 1.5 1 1 1 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 ORX70074.1 - 7.7e-05 22.3 0.1 0.00012 21.7 0.1 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 ORX70074.1 - 0.00083 18.8 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CH PF00307.31 ORX70075.1 - 1e-19 70.7 0.1 1.1e-19 70.6 0.1 1.0 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ORX70075.1 - 0.00023 20.9 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 ORX70075.1 - 0.0026 18.0 0.0 0.0036 17.5 0.0 1.2 1 0 0 1 1 1 1 CDC24 Calponin Sulfate_transp PF00916.20 ORX70077.1 - 5.4e-59 199.8 22.1 8.3e-59 199.2 22.1 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 ORX70077.1 - 8.1e-15 54.7 0.0 1.6e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 ORX70077.1 - 9.7e-10 38.1 0.0 1.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX70077.1 - 0.0011 19.4 19.0 0.015 15.7 3.6 3.7 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ORX70077.1 - 0.069 13.5 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 STAS domain TAF8_C PF10406.9 ORX70078.1 - 3e-14 53.3 0.3 3e-14 53.3 0.3 3.9 4 1 1 5 5 5 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 ORX70078.1 - 1.5e-11 44.1 0.0 3.3e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Peptidase_C54 PF03416.19 ORX70079.1 - 7.8e-84 281.3 0.0 9.9e-84 281.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Esterase PF00756.20 ORX70080.1 - 5.3e-57 193.3 0.1 6.2e-57 193.1 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ORX70080.1 - 4e-05 23.0 0.1 0.00047 19.5 0.1 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ORX70080.1 - 0.00014 20.9 0.0 0.00025 20.0 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 ORX70080.1 - 0.00037 20.0 0.2 0.0005 19.6 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.25 ORX70080.1 - 0.002 18.0 0.2 0.0064 16.4 0.0 1.9 3 0 0 3 3 3 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ORX70080.1 - 0.0072 17.0 0.2 0.024 15.2 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX70080.1 - 0.009 15.7 0.1 0.02 14.5 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 ORX70080.1 - 0.015 14.4 0.0 0.035 13.1 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_2 PF02230.16 ORX70080.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 ORX70080.1 - 0.05 13.4 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thiolase_N PF00108.23 ORX70081.1 - 1.1e-81 274.0 5.6 1.6e-81 273.5 5.6 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX70081.1 - 2e-33 114.7 0.3 2e-33 114.7 0.3 2.3 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX70081.1 - 2.4e-05 24.0 2.7 2.4e-05 24.0 2.7 3.2 3 1 1 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ORX70081.1 - 0.0056 16.5 0.4 0.0056 16.5 0.4 3.1 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Robl_LC7 PF03259.17 ORX70082.1 - 0.017 14.9 1.2 4 7.3 0.0 3.1 2 1 2 4 4 4 0 Roadblock/LC7 domain MDM31_MDM32 PF08118.11 ORX70083.1 - 8.3e-127 424.0 0.0 1e-93 314.8 0.0 2.6 1 1 1 2 2 2 2 Yeast mitochondrial distribution and morphology (MDM) proteins PAS_2 PF08446.11 ORX70084.1 - 0.014 16.0 0.0 0.029 15.0 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_4 PF08448.10 ORX70084.1 - 0.019 15.2 0.0 0.35 11.2 0.0 2.8 4 0 0 4 4 4 0 PAS fold PAS_9 PF13426.7 ORX70084.1 - 0.049 13.9 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 PAS domain DUF1825 PF08855.10 ORX70084.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) MFS_1 PF07690.16 ORX70085.1 - 6.1e-07 28.7 20.6 1.2e-06 27.7 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 ORX70085.1 - 0.047 13.5 0.9 6.7 6.5 0.0 2.6 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Vault_3 PF17795.1 ORX70085.1 - 0.099 12.7 0.0 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 Major Vault Protein Repeat domain SLATT_5 PF18160.1 ORX70085.1 - 4.4 6.6 6.0 2.6 7.3 3.8 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MFS_1 PF07690.16 ORX70086.1 - 1.2e-24 86.9 37.9 5.6e-22 78.1 40.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70086.1 - 9.1e-06 24.8 28.6 0.00024 20.1 14.1 3.3 2 2 1 3 3 3 2 Sugar (and other) transporter DUF5381 PF17353.2 ORX70086.1 - 3.8 7.2 7.9 0.24 11.1 2.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5381) MFS_1 PF07690.16 ORX70087.1 - 4.7e-22 78.4 94.7 1.5e-20 73.5 58.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70087.1 - 8.7e-05 21.6 18.8 8.7e-05 21.6 18.8 3.3 1 1 1 3 3 3 1 Sugar (and other) transporter CI-B14_5a PF07347.12 ORX70087.1 - 0.19 11.7 0.1 0.33 10.9 0.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) MFS_2 PF13347.6 ORX70087.1 - 1.4 7.4 46.0 0.079 11.5 13.2 3.2 1 1 2 3 3 3 0 MFS/sugar transport protein Aldo_ket_red PF00248.21 ORX70088.1 - 1.5e-49 168.8 0.0 9.6e-49 166.1 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family Bromo_TP PF07524.13 ORX70088.1 - 0.088 12.8 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated HypF_C PF17788.1 ORX70088.1 - 0.091 13.5 0.0 0.21 12.3 0.0 1.6 1 0 0 1 1 1 0 HypF Kae1-like domain UcrQ PF02939.16 ORX70089.1 - 2.5e-27 94.6 0.6 3e-27 94.3 0.6 1.0 1 0 0 1 1 1 1 UcrQ family Mannosyl_trans2 PF04188.13 ORX70090.1 - 7.1e-90 302.4 24.4 8.6e-90 302.2 24.4 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) Cofac_haem_bdg PF04187.13 ORX70091.1 - 0.064 13.2 0.0 0.086 12.8 0.0 1.2 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Aminotran_1_2 PF00155.21 ORX70092.1 - 1.2e-55 189.2 0.0 1.4e-55 189.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ORX70092.1 - 2.4e-05 23.8 0.0 5.5e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ORX70092.1 - 0.00035 19.7 0.0 0.00066 18.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ORX70092.1 - 0.00038 19.1 0.0 0.00062 18.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ORX70092.1 - 0.00075 18.9 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Amidohydro_1 PF01979.20 ORX70092.1 - 0.076 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase family Tubulin PF00091.25 ORX70093.1 - 2.5e-66 223.6 0.0 4.6e-66 222.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX70093.1 - 3.6e-37 127.3 0.1 5.5e-37 126.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX70093.1 - 8.3e-07 29.3 0.0 1.5e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ORX70093.1 - 0.0023 17.7 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ORX70093.1 - 0.0027 17.0 0.0 0.0056 15.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin like PTPA PF03095.15 ORX70094.1 - 4.6e-116 387.5 0.0 5.1e-116 387.3 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Proteasome PF00227.26 ORX70095.1 - 1.1e-50 171.7 0.1 1.4e-50 171.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ORX70095.1 - 3.6e-06 26.3 0.2 3.6e-06 26.3 0.2 2.1 2 0 0 2 2 2 1 Proteasome beta subunits C terminal zf-C3HC4_2 PF13923.6 ORX70096.1 - 0.22 11.4 5.6 6.3 6.7 1.0 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX70096.1 - 0.61 10.1 8.2 1.3 9.0 4.1 2.3 2 1 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX70096.1 - 1.1 9.1 7.6 1.4 8.8 2.9 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX70096.1 - 4.6 7.2 9.7 26 4.8 0.4 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Tnp_zf-ribbon_2 PF13842.6 ORX70096.1 - 9.1 7.2 10.2 4.5 8.2 0.4 3.0 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Myb_DNA-binding PF00249.31 ORX70097.1 - 5.2e-23 81.0 18.1 1.2e-06 28.6 0.2 6.0 5 1 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX70097.1 - 3.8e-22 78.3 4.9 1.3e-09 38.1 0.1 5.3 3 2 2 5 5 5 4 Myb-like DNA-binding domain CobU PF02283.16 ORX70097.1 - 0.0017 18.0 0.4 3.8 7.1 0.3 3.0 3 0 0 3 3 3 2 Cobinamide kinase / cobinamide phosphate guanyltransferase Myb_DNA-bind_4 PF13837.6 ORX70097.1 - 0.0041 17.5 11.5 0.51 10.8 0.4 4.6 4 1 1 5 5 5 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 ORX70097.1 - 0.099 12.7 0.6 3.4 7.8 0.0 2.6 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.9 ORX70097.1 - 0.92 9.9 11.7 13 6.2 0.8 4.8 4 1 1 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like GCFC PF07842.12 ORX70098.1 - 4.4e-19 69.2 7.8 5.5e-19 68.8 4.2 2.2 1 1 1 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 ORX70098.1 - 2.8e-13 49.5 0.7 5.1e-13 48.7 0.7 1.5 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 ORX70098.1 - 7e-08 32.8 0.0 7e-08 32.8 0.0 2.4 1 1 1 2 2 2 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 ORX70098.1 - 0.00084 19.4 0.1 0.0024 17.9 0.1 1.9 1 0 0 1 1 1 1 G-patch domain AF-4 PF05110.13 ORX70098.1 - 0.013 13.6 13.0 0.018 13.2 13.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pyr_redox_2 PF07992.14 ORX70099.1 - 8.9e-17 61.2 0.8 8.9e-16 58.0 0.8 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX70099.1 - 0.001 19.1 0.1 0.35 10.9 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 ORX70099.1 - 0.0014 18.3 0.4 0.036 13.7 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX70099.1 - 0.0026 18.0 0.4 0.0075 16.5 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ORX70099.1 - 0.0028 16.7 0.1 0.023 13.8 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 ORX70099.1 - 0.0045 16.1 0.1 0.0067 15.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ORX70099.1 - 0.0049 15.6 0.0 0.0084 14.9 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ORX70099.1 - 0.016 14.5 2.4 0.12 11.6 0.2 3.0 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX70099.1 - 0.044 14.4 2.2 0.1 13.2 0.5 2.4 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ORX70099.1 - 0.058 12.2 0.3 0.24 10.2 0.3 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.17 ORX70099.1 - 0.096 11.9 0.2 0.2 10.8 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Ipi1_N PF12333.8 ORX70100.1 - 2.2e-20 73.1 0.0 7.1e-20 71.5 0.0 1.9 1 0 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation HEAT_EZ PF13513.6 ORX70100.1 - 0.032 14.7 0.5 4.8 7.8 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat MBOAT_2 PF13813.6 ORX70100.1 - 0.039 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family MFS_1 PF07690.16 ORX70101.1 - 4.5e-23 81.7 42.7 4.5e-23 81.7 42.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70101.1 - 0.00014 20.9 13.6 0.00014 20.9 13.6 3.2 1 1 2 3 3 3 2 Sugar (and other) transporter Pam17 PF08566.10 ORX70101.1 - 0.36 10.7 2.4 0.59 10.0 0.5 2.2 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 MFS_1 PF07690.16 ORX70102.1 - 3.8e-23 82.0 34.3 6.8e-23 81.2 33.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70102.1 - 1.7e-05 23.9 25.3 6.6e-05 22.0 4.4 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 ORX70102.1 - 0.00038 19.4 23.2 0.00071 18.5 10.3 3.0 1 1 1 2 2 2 2 MFS_1 like family OATP PF03137.20 ORX70102.1 - 3.9 5.7 15.5 1.9 6.7 0.4 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family SelR PF01641.18 ORX70103.1 - 7.4e-54 181.0 0.1 8.3e-54 180.8 0.1 1.0 1 0 0 1 1 1 1 SelR domain GFA PF04828.14 ORX70103.1 - 0.0024 18.2 0.3 0.15 12.4 0.0 2.1 1 1 1 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_10 PF10058.9 ORX70103.1 - 0.0053 16.5 0.2 0.19 11.5 0.0 2.2 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 ORX70103.1 - 0.0073 16.5 0.4 0.021 15.0 0.4 1.7 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 ORX70103.1 - 0.028 14.4 0.2 0.077 13.0 0.1 1.8 2 1 0 2 2 2 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.6 ORX70103.1 - 0.049 14.4 0.2 3.2 8.6 0.0 2.3 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Evr1_Alr PF04777.13 ORX70104.1 - 9.7e-31 106.2 1.3 1.1e-30 106.1 1.3 1.0 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC4 PF18775.1 ORX70104.1 - 0.091 12.9 0.2 0.19 11.9 0.2 1.5 1 1 0 1 1 1 0 APOBEC4 MFAP1 PF06991.11 ORX70105.1 - 8e-26 91.2 20.2 8e-26 91.2 20.2 2.4 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing Ecl1 PF12855.7 ORX70105.1 - 5.1 8.2 11.8 4.7 8.3 10.6 1.5 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins Vfa1 PF08432.10 ORX70106.1 - 1.2e-16 61.5 8.4 5.7e-11 43.1 0.2 2.0 1 1 1 2 2 2 2 AAA-ATPase Vps4-associated protein 1 U1snRNP70_N PF12220.8 ORX70107.1 - 1e-20 74.1 4.3 1e-20 74.1 4.3 1.9 2 1 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 ORX70107.1 - 1.5e-19 69.6 0.0 2.5e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RGS PF00615.19 ORX70108.1 - 3.3e-13 49.9 0.0 7.2e-13 48.9 0.0 1.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 ORX70108.1 - 5.4e-07 29.5 0.0 9.1e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain MRP-S25 PF13741.6 ORX70109.1 - 2.7e-46 158.0 6.1 3.4e-46 157.6 6.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 ORX70109.1 - 0.039 14.2 0.7 0.28 11.5 0.1 2.5 2 1 0 2 2 2 0 Mitochondrial ribosomal protein S23 MutL_C PF08676.11 ORX70110.1 - 2.5e-13 50.0 0.0 1.2e-11 44.6 0.0 2.7 2 1 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 ORX70110.1 - 5.3e-08 32.8 0.0 9.2e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX70110.1 - 8.1e-05 23.1 0.1 0.00023 21.6 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aldo_ket_red PF00248.21 ORX70111.1 - 1.2e-46 159.3 0.0 4.6e-45 154.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family SH3_1 PF00018.28 ORX70112.1 - 6.8e-13 48.0 0.1 1.3e-12 47.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain Transglut_core PF01841.19 ORX70112.1 - 3.2e-09 37.2 0.0 1e-08 35.6 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_9 PF14604.6 ORX70112.1 - 3.6e-06 26.7 0.1 1.3e-05 25.0 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX70112.1 - 8.7e-06 25.3 0.0 1.8e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain HSP90 PF00183.18 ORX70113.1 - 2.3e-104 350.1 0.0 4.1e-100 336.1 0.0 2.2 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 ORX70113.1 - 1.4e-11 44.4 0.2 2.8e-11 43.4 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX70113.1 - 6.7e-07 29.8 0.2 1.9e-06 28.3 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Syja_N PF02383.18 ORX70115.1 - 5.5e-80 269.1 0.0 6.9e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Exo70 PF03081.15 ORX70116.1 - 6.9e-53 180.0 0.0 7e-51 173.4 0.0 2.3 2 1 0 2 2 2 2 Exo70 exocyst complex subunit RINT1_TIP1 PF04437.13 ORX70117.1 - 6.2e-82 276.1 0.0 9.6e-82 275.4 0.0 1.3 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DUF4168 PF13767.6 ORX70117.1 - 0.78 11.0 4.3 10 7.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4168) HAUS2 PF15003.6 ORX70118.1 - 7.9e-08 32.2 2.1 1.1e-07 31.8 2.1 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 DHC_N1 PF08385.12 ORX70118.1 - 0.0022 16.7 1.9 0.0035 16.1 1.9 1.4 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Med21 PF11221.8 ORX70118.1 - 0.032 14.5 5.9 0.41 10.9 5.9 2.3 1 1 0 1 1 1 0 Subunit 21 of Mediator complex End3 PF12761.7 ORX70118.1 - 0.056 13.6 3.8 0.7 10.0 0.1 2.1 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF2285 PF10074.9 ORX70118.1 - 0.11 13.1 5.4 0.74 10.5 0.2 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2285) DUF2203 PF09969.9 ORX70118.1 - 0.23 12.2 2.5 16 6.2 0.1 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fibin PF15819.5 ORX70118.1 - 0.84 9.4 5.2 1.6 8.5 0.2 2.1 2 0 0 2 2 2 0 Fin bud initiation factor homologue FTA4 PF13093.6 ORX70118.1 - 2.9 7.7 6.8 1.7 8.5 0.9 2.2 1 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 PRP1_N PF06424.12 ORX70118.1 - 8.4 6.8 9.0 0.67 10.3 2.2 2.3 2 1 1 3 3 3 0 PRP1 splicing factor, N-terminal Pkinase PF00069.25 ORX70119.1 - 1.2e-49 169.0 0.0 4.1e-49 167.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70119.1 - 1.4e-25 90.1 0.0 5.1e-25 88.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase CRAL_TRIO PF00650.20 ORX70120.1 - 1.5e-32 112.5 0.0 2e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ORX70120.1 - 1.4e-06 28.5 0.0 2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX70120.1 - 0.00012 22.1 0.2 0.00077 19.6 0.5 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Cas_Cas1 PF01867.16 ORX70120.1 - 0.21 10.7 0.1 0.27 10.4 0.1 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas1 zf-CCHC PF00098.23 ORX70121.1 - 4.3e-13 48.7 29.8 0.0019 18.2 0.3 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 ORX70121.1 - 1.2e-05 25.0 0.9 1.2e-05 25.0 0.9 4.2 4 0 0 4 4 4 2 Zinc knuckle DUF3807 PF12720.7 ORX70121.1 - 0.02 15.2 7.7 0.02 15.2 7.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) zf-CCHC_4 PF14392.6 ORX70121.1 - 0.028 14.1 26.9 0.05 13.3 0.9 4.3 4 0 0 4 4 4 0 Zinc knuckle V_ATPase_I PF01496.19 ORX70121.1 - 3 5.7 6.5 4.6 5.0 6.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ORX70121.1 - 3 6.5 7.7 4.2 6.1 7.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop53 PF07767.11 ORX70122.1 - 9.4e-67 226.1 53.6 1.9e-65 221.8 53.6 2.0 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) CM_2 PF01817.21 ORX70123.1 - 0.00012 22.4 0.2 0.037 14.4 0.0 2.6 2 1 0 2 2 2 2 Chorismate mutase type II FGGY_N PF00370.21 ORX70123.1 - 0.083 12.4 0.0 0.18 11.3 0.0 1.5 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain FAD_syn PF06574.12 ORX70123.1 - 0.11 12.4 0.0 9.8 6.0 0.0 2.2 2 0 0 2 2 2 0 FAD synthetase SWIRM PF04433.17 ORX70125.1 - 1.3e-09 38.3 0.0 3e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Glyoxalase PF00903.25 ORX70127.1 - 5.9e-21 75.0 2.9 4.5e-14 52.7 0.1 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ORX70127.1 - 6.8e-14 52.1 0.3 8.2e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 ORX70127.1 - 1.7e-06 28.3 0.1 1.8e-05 24.9 0.1 2.3 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 ORX70127.1 - 0.0049 17.0 0.3 2.6 8.1 0.0 3.2 2 1 0 2 2 2 2 Glyoxalase-like domain Pkinase PF00069.25 ORX70128.1 - 1.9e-72 243.8 0.0 3.1e-72 243.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70128.1 - 3.5e-38 131.4 0.0 6.4e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX70128.1 - 2.5e-09 36.9 0.0 1.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like KA1 PF02149.19 ORX70128.1 - 2e-07 30.7 0.2 3.7e-07 29.8 0.2 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 ORX70128.1 - 0.0042 16.1 0.2 0.0069 15.4 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Phage_T7_Capsid PF05396.11 ORX70128.1 - 0.031 14.6 0.0 0.084 13.2 0.0 1.7 1 0 0 1 1 1 0 Phage T7 capsid assembly protein APH PF01636.23 ORX70128.1 - 0.031 14.2 0.2 0.15 12.0 0.3 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX70128.1 - 0.094 12.1 0.1 0.22 10.8 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX70128.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 ORX70128.1 - 0.13 11.7 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ELO PF01151.18 ORX70130.1 - 5.7e-60 202.9 23.6 7.2e-60 202.6 23.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family HMG_box PF00505.19 ORX70133.1 - 4.8e-23 81.4 1.0 4.8e-23 81.4 1.0 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX70133.1 - 2.3e-15 56.9 1.4 2.3e-15 56.9 1.4 1.6 2 0 0 2 2 2 1 HMG-box domain YABBY PF04690.13 ORX70133.1 - 0.021 15.4 0.7 0.03 14.9 0.7 1.3 1 0 0 1 1 1 0 YABBY protein HMG_box_5 PF14887.6 ORX70133.1 - 0.18 11.8 6.2 0.058 13.4 1.7 2.2 1 1 1 2 2 2 0 HMG (high mobility group) box 5 DUF899 PF05988.12 ORX70134.1 - 0.002 17.7 2.1 0.52 9.8 0.1 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF899) Pkinase PF00069.25 ORX70135.1 - 1.6e-07 30.9 0.0 3.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70135.1 - 0.00021 20.6 0.0 0.00042 19.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase CbtB PF09489.10 ORX70135.1 - 0.11 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Seipin PF06775.14 ORX70136.1 - 3.4e-51 174.2 4.9 4.5e-51 173.8 4.9 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF1422 PF07226.11 ORX70136.1 - 0.06 13.3 1.1 0.12 12.4 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) Glyco_hydro_38N PF01074.22 ORX70137.1 - 1.8e-86 290.1 0.4 2.8e-86 289.4 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ORX70137.1 - 3.5e-56 190.7 0.0 6.6e-56 189.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ORX70137.1 - 1.3e-28 98.9 0.0 3.3e-28 97.7 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ORX70137.1 - 1.6e-13 50.6 0.0 3e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 ORX70137.1 - 3.7e-05 23.1 0.0 0.0001 21.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 57 NST1 PF13945.6 ORX70139.1 - 1.5e-26 93.7 18.2 1.5e-26 93.7 18.2 5.9 5 2 1 6 6 6 1 Salt tolerance down-regulator Ank_2 PF12796.7 ORX70140.1 - 4.5e-09 36.8 3.0 0.0043 17.6 0.4 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX70140.1 - 4.1e-08 33.6 5.8 0.0011 19.5 0.4 4.1 2 2 4 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX70140.1 - 1.5e-07 31.1 1.1 0.0062 17.0 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ORX70140.1 - 1.6e-06 28.3 5.6 0.01 16.3 0.2 3.2 3 0 0 3 3 3 2 Ankyrin repeat KilA-N PF04383.13 ORX70140.1 - 0.0068 16.3 0.5 0.12 12.3 0.5 2.4 1 1 0 1 1 1 1 KilA-N domain Ank_5 PF13857.6 ORX70140.1 - 0.0095 16.2 3.3 0.016 15.5 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Mod_r PF07200.13 ORX70140.1 - 0.69 10.0 3.9 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 ORX70140.1 - 0.77 8.6 6.8 4.1 6.2 1.9 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Latarcin PF10279.9 ORX70140.1 - 7.1 7.1 6.1 2.2 8.8 2.1 2.1 2 0 0 2 2 2 0 Latarcin precursor eIF2_C PF09173.11 ORX70141.1 - 1.2e-33 115.2 0.5 3.3e-33 113.8 0.5 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ORX70141.1 - 2.6e-23 82.6 1.7 2.1e-22 79.6 1.7 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ORX70141.1 - 2.7e-08 34.1 0.5 2.7e-08 34.1 0.5 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 ORX70141.1 - 7.7e-05 22.7 1.4 0.0037 17.2 0.4 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ORX70141.1 - 0.00054 20.0 0.0 0.0019 18.3 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 ORX70141.1 - 0.0038 17.2 0.1 0.0089 16.0 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain PduV-EutP PF10662.9 ORX70141.1 - 0.055 13.2 3.4 2.5 7.9 0.4 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF1098 PF06497.11 ORX70141.1 - 0.067 13.7 0.3 0.18 12.3 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1098) Pkinase_fungal PF17667.1 ORX70142.1 - 6.8e-19 67.9 0.0 7.1e-10 38.2 0.0 2.5 1 1 1 2 2 2 2 Fungal protein kinase APH PF01636.23 ORX70142.1 - 5.1e-07 29.9 0.0 0.00054 20.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 ORX70142.1 - 2.5e-06 27.1 0.0 3.9e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70142.1 - 0.0058 15.9 0.0 0.0083 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ORX70142.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family CUE PF02845.16 ORX70143.1 - 2.5e-11 43.1 0.0 3.7e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 CUE domain UBA PF00627.31 ORX70143.1 - 0.047 13.6 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain PTH2 PF01981.16 ORX70144.1 - 3.6e-09 36.9 0.0 3.9e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF1848 PF08902.11 ORX70144.1 - 0.089 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) PPR_2 PF13041.6 ORX70145.1 - 4.6e-07 29.9 0.4 1.3 9.3 0.0 5.5 4 1 1 5 5 5 2 PPR repeat family PPR_3 PF13812.6 ORX70145.1 - 3.9e-06 26.8 0.2 0.93 9.6 0.0 5.2 4 1 0 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX70145.1 - 0.0029 17.0 0.0 0.036 13.4 0.0 2.4 2 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ORX70145.1 - 0.009 16.2 0.4 9.4 6.7 0.1 4.5 5 0 0 5 5 5 1 PPR repeat RasGEF_N PF00618.20 ORX70145.1 - 0.09 13.0 0.0 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 RasGEF N-terminal motif RNA_pol PF00940.19 ORX70146.1 - 8.3e-161 535.4 0.6 1e-160 535.1 0.6 1.1 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 ORX70146.1 - 5.4e-49 167.4 0.6 3.7e-48 164.6 0.0 2.2 2 1 0 2 2 2 1 DNA-directed RNA polymerase N-terminal Transferase PF02458.15 ORX70147.1 - 9.6e-26 90.4 0.0 1.5e-25 89.7 0.0 1.3 1 1 0 1 1 1 1 Transferase family Condensation PF00668.20 ORX70147.1 - 3.1e-06 26.1 0.0 4.8e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Condensation domain HSF_DNA-bind PF00447.17 ORX70149.1 - 1.8e-31 108.6 0.2 4e-31 107.5 0.2 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Tmemb_cc2 PF10267.9 ORX70149.1 - 0.002 17.4 1.0 0.002 17.4 1.0 1.9 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein OmpH PF03938.14 ORX70149.1 - 0.13 12.6 4.3 3.2 8.1 0.7 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Syntaxin PF00804.25 ORX70149.1 - 0.2 11.3 4.8 0.1 12.2 0.7 2.1 2 0 0 2 2 2 0 Syntaxin Helo_like_N PF17111.5 ORX70149.1 - 0.66 9.3 3.0 0.31 10.4 0.2 1.8 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Cep57_MT_bd PF06657.13 ORX70149.1 - 0.8 10.2 5.3 2.8 8.4 0.8 2.9 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 TMF_DNA_bd PF12329.8 ORX70149.1 - 0.87 9.6 3.1 13 5.9 0.4 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 ORX70149.1 - 1.5 9.0 4.6 2.2 8.4 0.4 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 ORX70149.1 - 1.5 9.5 3.0 2.5 8.8 0.5 2.2 2 0 0 2 2 2 0 Initiation control protein YabA WDCP PF15390.6 ORX70149.1 - 3.3 6.0 7.5 0.19 10.1 1.1 1.8 1 1 0 2 2 2 0 WD repeat and coiled-coil-containing protein family zf-C2H2 PF00096.26 ORX70150.1 - 4.5e-14 52.0 31.1 0.00016 21.9 0.8 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX70150.1 - 4.7e-11 42.5 26.4 0.0025 18.5 0.4 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX70150.1 - 2.4e-10 40.4 26.1 0.00012 22.3 1.4 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-met PF12874.7 ORX70150.1 - 4.1e-05 23.8 13.1 0.017 15.5 0.2 5.0 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX70150.1 - 0.0011 19.1 11.9 0.093 13.1 0.1 4.7 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX70150.1 - 0.012 15.6 0.3 0.012 15.6 0.3 4.4 4 2 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ORX70150.1 - 0.12 13.0 4.5 3.8 8.2 0.1 3.7 2 2 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 ORX70150.1 - 0.95 9.8 13.4 1.2 9.4 8.8 3.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 ORX70150.1 - 8.2 6.4 15.3 3.7 7.6 0.2 4.0 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger DIM1 PF02966.16 ORX70152.1 - 2.3e-65 218.3 0.1 2.6e-65 218.2 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 ORX70152.1 - 5.2e-05 23.2 0.0 6.9e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredox_DsbH PF03190.15 ORX70152.1 - 0.025 14.5 0.2 0.045 13.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 ORX70152.1 - 0.082 13.1 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_8 PF13905.6 ORX70152.1 - 0.087 13.2 0.2 0.13 12.6 0.2 1.4 1 1 0 1 1 1 0 Thioredoxin-like Myb_DNA-binding PF00249.31 ORX70153.1 - 2e-10 40.7 0.1 5.8e-10 39.2 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 ORX70153.1 - 1.1e-06 28.9 0.1 7.2e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 SWIRM domain ZZ PF00569.17 ORX70153.1 - 5.8e-05 22.8 5.7 0.00012 21.8 5.7 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 ORX70153.1 - 0.0001 22.5 0.7 0.00025 21.2 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain zinc-ribbons_6 PF07191.12 ORX70153.1 - 0.15 12.1 4.8 0.35 10.9 4.8 1.6 1 0 0 1 1 1 0 zinc-ribbons Ribosomal_S17_N PF16205.5 ORX70154.1 - 5.8e-33 113.1 0.3 5.8e-33 113.1 0.3 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ORX70154.1 - 2.9e-26 91.4 0.2 2.9e-26 91.4 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein S17 PRF PF06875.11 ORX70154.1 - 0.13 11.7 0.2 0.2 11.0 0.1 1.5 2 0 0 2 2 2 0 Plethodontid receptivity factor PRF DUF2015 PF09435.10 ORX70155.1 - 1.8e-24 85.8 0.0 2.2e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) CDC27 PF09507.10 ORX70156.1 - 1.2e-38 133.6 47.5 8.1e-20 71.6 39.3 2.1 1 1 0 2 2 2 2 DNA polymerase subunit Cdc27 Rhodanese PF00581.20 ORX70157.1 - 2.2e-08 34.6 0.0 2.5e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain dsDNA_bind PF01984.20 ORX70159.1 - 9.7e-34 116.0 10.6 1.1e-33 115.8 10.6 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain FeoC PF09012.10 ORX70159.1 - 0.034 14.2 1.3 0.12 12.5 1.3 1.9 1 1 0 1 1 1 0 FeoC like transcriptional regulator TMP_2 PF06791.13 ORX70160.1 - 0.0014 18.4 1.0 0.002 17.8 1.0 1.2 1 0 0 1 1 1 1 Prophage tail length tape measure protein YABBY PF04690.13 ORX70161.1 - 1.4e-10 42.0 0.2 1.4e-10 41.9 0.2 1.2 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.19 ORX70161.1 - 2.4e-07 31.1 1.1 3.2e-07 30.7 1.1 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX70161.1 - 6.9e-06 26.6 0.6 1e-05 26.1 0.6 1.2 1 0 0 1 1 1 1 HMG-box domain Ccdc124 PF06244.12 ORX70161.1 - 3.9e-05 24.2 0.3 3.9e-05 24.2 0.3 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 L51_S25_CI-B8 PF05047.16 ORX70161.1 - 0.006 16.5 0.1 0.0096 15.8 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain tRNA-synt_2 PF00152.20 ORX70162.1 - 4.3e-71 239.5 0.0 6.3e-71 239.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX70162.1 - 6e-11 42.2 0.1 1.2e-10 41.2 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX70162.1 - 2.1e-06 27.4 0.2 0.0019 17.8 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DEAD PF00270.29 ORX70163.1 - 1.7e-43 148.4 0.0 4.7e-43 147.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX70163.1 - 1.4e-29 102.7 0.0 3.9e-29 101.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX70163.1 - 8.8e-05 22.6 0.0 0.00036 20.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 ORX70163.1 - 0.028 14.5 0.4 0.047 13.8 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle HSA PF07529.13 ORX70164.1 - 1.9e-13 50.5 1.9 1.9e-13 50.5 1.9 2.5 3 0 0 3 3 3 1 HSA SF3b1 PF08920.10 ORX70165.1 - 7.4e-30 103.9 10.8 6e-28 97.7 0.6 3.8 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 ORX70165.1 - 5.8e-10 39.4 22.1 0.042 14.2 0.2 7.6 5 1 3 8 8 8 5 HEAT repeats HEAT PF02985.22 ORX70165.1 - 3.2e-08 33.1 20.0 0.023 14.9 0.3 8.1 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 ORX70165.1 - 1.3e-07 31.9 21.9 0.26 11.8 0.3 7.4 8 1 0 8 8 8 4 HEAT-like repeat Arm PF00514.23 ORX70165.1 - 0.00019 21.3 8.5 16 5.7 0.1 6.4 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ORX70165.1 - 0.00059 19.9 1.8 55 3.7 0.0 5.9 6 1 1 7 7 7 0 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX70165.1 - 0.0011 18.5 0.0 12 5.4 0.0 4.3 4 1 1 5 5 5 1 CLASP N terminal NUC173 PF08161.12 ORX70165.1 - 0.013 15.2 0.0 2.7 7.6 0.0 3.3 3 0 0 3 3 3 0 NUC173 domain Dopey_N PF04118.14 ORX70165.1 - 0.13 11.3 0.0 5.6 6.0 0.0 2.6 3 0 0 3 3 3 0 Dopey, N-terminal WD40 PF00400.32 ORX70167.1 - 3.6e-72 236.5 24.7 7.3e-10 39.3 0.1 9.2 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70167.1 - 6.6e-26 90.4 2.1 0.00022 21.4 0.0 5.4 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 ORX70167.1 - 1.4e-13 51.1 0.1 2.5e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 ORX70167.1 - 1.3e-08 35.0 0.3 0.0011 18.9 0.0 3.8 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX70167.1 - 2.5e-07 30.0 1.0 0.19 10.6 0.2 4.9 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX70167.1 - 3.2e-07 29.4 8.6 0.055 12.1 0.2 5.9 3 3 3 6 6 6 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ORX70167.1 - 1.6e-06 27.7 1.2 0.21 10.9 0.0 3.9 3 2 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ORX70167.1 - 0.00064 18.3 0.0 0.011 14.3 0.0 2.5 2 1 1 3 3 3 1 Cytochrome D1 heme domain CHAP PF05257.16 ORX70167.1 - 0.0043 17.6 2.5 0.78 10.4 0.0 4.2 2 2 1 4 4 4 1 CHAP domain Proteasome_A_N PF10584.9 ORX70167.1 - 0.0089 15.7 3.3 3.2 7.5 0.0 3.9 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 ORX70167.1 - 0.015 15.2 0.8 7.7 6.6 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat IKI3 PF04762.12 ORX70167.1 - 0.016 13.3 0.5 0.98 7.3 0.0 2.4 2 1 0 2 2 2 0 IKI3 family Frtz PF11768.8 ORX70167.1 - 0.022 13.1 0.0 1.2 7.4 0.0 2.8 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 ORX70167.1 - 0.053 12.4 5.3 7.8 5.3 0.0 4.0 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Ret2_MD PF18528.1 ORX70167.1 - 0.2 12.1 0.0 9.5 6.7 0.0 2.8 2 0 0 2 2 2 0 RNA editing 3' terminal uridylyl transferase 2 middle domain WD40_like PF17005.5 ORX70167.1 - 0.26 10.6 0.0 58 2.9 0.0 3.1 2 1 1 3 3 3 0 WD40-like domain Prefoldin PF02996.17 ORX70168.1 - 1.6e-20 73.2 2.1 2.4e-20 72.6 2.1 1.3 1 1 0 1 1 1 1 Prefoldin subunit betaPIX_CC PF16523.5 ORX70168.1 - 0.027 14.3 0.8 0.088 12.6 0.1 2.0 2 1 0 2 2 2 0 betaPIX coiled coil 14-3-3 PF00244.20 ORX70169.1 - 1e-101 339.1 4.5 1.5e-101 338.5 4.5 1.3 1 0 0 1 1 1 1 14-3-3 protein Ima1_N PF09779.9 ORX70169.1 - 0.1 13.5 0.4 3.9 8.3 0.0 2.4 2 1 0 2 2 2 0 Ima1 N-terminal domain 2_5_RNA_ligase2 PF13563.6 ORX70170.1 - 0.056 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily DSS1_SEM1 PF05160.13 ORX70171.1 - 1.3e-20 73.2 19.8 1.7e-20 72.8 19.8 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.8 ORX70171.1 - 0.022 14.6 2.9 0.022 14.6 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Syja_N PF02383.18 ORX70172.1 - 3.6e-71 240.1 0.0 6.1e-71 239.4 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain MRP-L28 PF09812.9 ORX70173.1 - 6.8e-14 52.3 1.3 8.7e-14 52.0 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF4375 PF14300.6 ORX70173.1 - 0.075 13.3 0.9 0.11 12.8 0.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) NPR3 PF03666.13 ORX70174.1 - 0.063 12.1 4.3 0.094 11.5 4.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2992 PF11208.8 ORX70174.1 - 0.22 11.7 13.5 1.5 9.1 11.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) RR_TM4-6 PF06459.12 ORX70174.1 - 3.5 7.4 11.2 12 5.6 8.6 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PVL_ORF50 PF07768.11 ORX70174.1 - 9.8 6.5 11.3 22 5.4 11.3 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family FYRN PF05964.14 ORX70175.1 - 2.7e-16 59.1 0.1 5.8e-16 58.1 0.1 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 ORX70175.1 - 4.5e-14 52.4 0.0 9.5e-14 51.3 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus DUF846 PF05832.12 ORX70176.1 - 5.3e-55 185.3 9.4 5.9e-55 185.1 9.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) VirB3 PF05101.13 ORX70176.1 - 2.2 8.6 13.5 0.085 13.1 3.9 2.2 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein TOM13 PF08219.11 ORX70177.1 - 2e-13 50.1 0.3 3e-13 49.5 0.3 1.3 1 0 0 1 1 1 1 Outer membrane protein TOM13 PilM PF07419.12 ORX70177.1 - 0.12 12.5 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 PilM H2TH PF06831.14 ORX70177.1 - 0.21 11.6 0.0 0.38 10.8 0.0 1.3 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain EMP24_GP25L PF01105.24 ORX70178.1 - 2.1e-36 125.6 0.0 2.4e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Rx_N PF18052.1 ORX70178.1 - 0.049 13.9 0.1 0.097 13.0 0.1 1.5 1 0 0 1 1 1 0 Rx N-terminal domain Ecl1 PF12855.7 ORX70179.1 - 0.14 13.3 8.2 0.31 12.2 8.2 1.5 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins FMN_dh PF01070.18 ORX70180.1 - 1.5e-125 418.9 0.0 1.8e-125 418.6 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ORX70180.1 - 6.9e-06 25.3 3.7 2.5e-05 23.4 0.4 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 ORX70180.1 - 0.00013 21.3 0.7 0.22 10.8 0.0 3.0 2 2 1 3 3 3 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 ORX70180.1 - 0.00039 19.7 0.1 0.00057 19.1 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 ORX70180.1 - 0.0063 15.9 0.8 0.027 13.8 0.9 1.8 1 1 1 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 ORX70180.1 - 0.018 14.5 0.0 0.069 12.6 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein G3P_antiterm PF04309.12 ORX70180.1 - 0.035 13.5 0.0 7.1 6.0 0.0 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Ecl1 PF12855.7 ORX70181.1 - 0.14 13.3 8.2 0.31 12.2 8.2 1.5 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins HMG_box PF00505.19 ORX70182.1 - 8e-32 109.5 10.4 2.9e-18 66.0 1.8 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX70182.1 - 4.1e-10 40.1 10.4 1.4e-06 28.8 1.0 2.3 2 0 0 2 2 2 2 HMG-box domain MATalpha_HMGbox PF04769.12 ORX70182.1 - 3.5e-05 23.2 2.5 0.0017 17.7 0.7 2.2 1 1 1 2 2 2 2 Mating-type protein MAT alpha 1 HMG-box Halogen_Hydrol PF10112.9 ORX70182.1 - 0.028 14.4 1.1 0.22 11.5 0.2 2.1 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF2115 PF09888.9 ORX70182.1 - 0.58 10.7 5.7 1.1 9.8 4.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) VitD-bind_III PF09164.10 ORX70182.1 - 2.8 8.0 5.1 13 5.9 0.5 2.8 3 0 0 3 3 3 0 Vitamin D binding protein, domain III DAGK_cat PF00781.24 ORX70183.1 - 3.8e-23 81.5 0.0 6.1e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain WD40 PF00400.32 ORX70184.1 - 1.5e-07 32.0 7.3 0.061 14.2 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70184.1 - 0.012 15.9 0.0 3 8.2 0.0 3.5 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Mito_carr PF00153.27 ORX70185.1 - 2.1e-58 194.3 5.0 4e-20 71.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Oxidored_FMN PF00724.20 ORX70187.1 - 5.9e-66 223.1 0.0 7e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ORX70187.1 - 0.16 11.0 0.0 0.29 10.2 0.0 1.5 1 1 0 1 1 1 0 Dihydrouridine synthase (Dus) AAA PF00004.29 ORX70189.1 - 3.9e-16 59.7 0.0 6.9e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX70189.1 - 4.3e-11 43.5 0.0 2.5e-10 41.0 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX70189.1 - 1.6e-10 41.4 0.0 3.1e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 ORX70189.1 - 4.8e-10 39.5 0.0 1.6e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 AAA lid domain Cdc6_C PF09079.11 ORX70189.1 - 9.6e-09 35.1 0.0 2.6e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_19 PF13245.6 ORX70189.1 - 1e-05 25.9 1.1 0.00013 22.3 0.1 2.4 2 2 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX70189.1 - 3.5e-05 23.6 0.8 0.021 14.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 ORX70189.1 - 0.00019 20.8 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ORX70189.1 - 0.0055 16.6 0.0 0.0098 15.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_11 PF13086.6 ORX70189.1 - 0.012 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 ORX70189.1 - 0.036 13.5 0.0 0.27 10.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein Viral_helicase1 PF01443.18 ORX70189.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 ORX70189.1 - 0.074 13.0 0.0 0.23 11.4 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ORX70189.1 - 0.098 11.8 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 ORX70189.1 - 0.16 11.3 0.2 4.2 6.6 0.0 2.2 2 0 0 2 2 2 0 KaiC DUF1677 PF07911.13 ORX70190.1 - 0.16 12.4 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1677) Spt20 PF12090.8 ORX70190.1 - 0.27 10.8 10.5 0.49 10.0 10.5 1.3 1 0 0 1 1 1 0 Spt20 family Amidase PF01425.21 ORX70191.1 - 1e-98 331.2 1.2 1.2e-98 331.0 1.2 1.0 1 0 0 1 1 1 1 Amidase Ints3 PF10189.9 ORX70192.1 - 1.5e-77 259.9 0.0 2.4e-77 259.2 0.0 1.3 1 0 0 1 1 1 1 Integrator complex subunit 3 Oxidored_FMN PF00724.20 ORX70193.1 - 1.4e-76 258.0 0.0 1.7e-76 257.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Myb_DNA-binding PF00249.31 ORX70193.1 - 0.46 10.7 0.1 0.46 10.7 0.1 1.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain RRM_1 PF00076.22 ORX70194.1 - 2.8e-13 49.5 0.0 6.5e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Surp PF01805.20 ORX70194.1 - 1.8e-10 40.6 0.0 3.5e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Surp module CTD_bind PF04818.13 ORX70194.1 - 0.00012 22.8 0.0 0.00037 21.3 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 ORX70194.1 - 0.024 14.8 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif DUF2067 PF09840.9 ORX70194.1 - 0.26 10.8 0.3 1.5 8.4 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) CBF PF03914.17 ORX70195.1 - 4.3e-45 153.8 1.0 4.3e-45 153.8 1.0 3.2 3 0 0 3 3 3 2 CBF/Mak21 family BUD22 PF09073.10 ORX70195.1 - 0.00075 19.0 20.2 0.00075 19.0 20.2 3.3 3 0 0 3 3 3 2 BUD22 Cnd1 PF12717.7 ORX70195.1 - 0.024 14.7 2.2 0.082 13.0 2.2 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 RICTOR_M PF14666.6 ORX70195.1 - 0.054 13.3 0.7 0.15 11.8 0.2 2.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Ribosomal_S10 PF00338.22 ORX70196.1 - 1.7e-26 92.3 0.4 5.5e-26 90.7 0.0 2.0 2 1 0 2 2 2 1 Ribosomal protein S10p/S20e Trypsin PF00089.26 ORX70197.1 - 6.6e-32 111.1 2.5 8e-32 110.8 2.5 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX70197.1 - 0.0013 19.6 0.4 0.0024 18.8 0.4 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain TIP49 PF06068.13 ORX70199.1 - 1e-158 528.2 1.4 1.6e-158 527.5 1.4 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ORX70199.1 - 2.6e-24 85.1 1.2 6.3e-24 83.9 1.2 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ORX70199.1 - 1.7e-10 41.5 1.8 5e-06 27.0 0.1 3.1 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX70199.1 - 3.6e-10 39.8 2.3 7.9e-05 22.4 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX70199.1 - 3.2e-05 24.2 0.0 0.037 14.3 0.0 2.5 1 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ORX70199.1 - 4.2e-05 23.9 0.8 4.2e-05 23.9 0.8 2.6 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ORX70199.1 - 5e-05 22.8 0.7 0.017 14.5 0.4 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX70199.1 - 5.2e-05 23.3 0.1 0.076 13.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) DnaB_C PF03796.15 ORX70199.1 - 5.3e-05 22.7 0.4 0.00013 21.4 0.4 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 ORX70199.1 - 8.7e-05 22.3 0.2 0.28 10.9 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 ORX70199.1 - 0.00035 21.0 0.0 0.0025 18.2 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ORX70199.1 - 0.0037 17.3 0.1 0.56 10.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.6 ORX70199.1 - 0.0045 17.4 1.0 0.012 16.1 0.4 2.1 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 ORX70199.1 - 0.0048 17.0 0.2 5.3 7.1 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain ATPase PF06745.13 ORX70199.1 - 0.0051 16.2 0.1 0.013 14.8 0.1 1.7 1 0 0 1 1 1 1 KaiC Zeta_toxin PF06414.12 ORX70199.1 - 0.0061 15.9 0.3 0.016 14.5 0.3 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.6 ORX70199.1 - 0.0067 16.7 0.1 0.025 14.8 0.1 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 ORX70199.1 - 0.011 15.5 0.6 0.88 9.2 0.3 2.5 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ORX70199.1 - 0.02 14.2 0.0 0.037 13.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ORX70199.1 - 0.029 13.9 0.6 0.12 11.9 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region PIF1 PF05970.14 ORX70199.1 - 0.038 13.2 0.9 3.6 6.7 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase MS_channel PF00924.18 ORX70199.1 - 0.045 13.3 0.2 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel AAA_33 PF13671.6 ORX70199.1 - 0.05 13.8 0.1 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 ORX70199.1 - 0.068 13.0 0.0 0.39 10.5 0.0 2.1 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein IstB_IS21 PF01695.17 ORX70199.1 - 0.15 11.8 1.3 0.19 11.4 0.2 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein HMG_box PF00505.19 ORX70200.1 - 3.1e-13 49.9 4.6 7.4e-13 48.7 4.6 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box MATalpha_HMGbox PF04769.12 ORX70200.1 - 0.017 14.4 0.1 0.032 13.5 0.1 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box HMG_box_2 PF09011.10 ORX70200.1 - 0.061 13.9 6.3 0.13 12.9 6.3 1.5 1 0 0 1 1 1 0 HMG-box domain ABC_tran PF00005.27 ORX70202.1 - 1.3e-46 158.5 0.0 2.4e-23 83.1 0.0 3.0 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ORX70202.1 - 4.6e-21 74.6 6.3 4.6e-21 74.6 6.3 2.0 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 ORX70202.1 - 1.5e-11 44.7 15.3 0.0035 17.2 0.6 4.7 3 2 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX70202.1 - 7.2e-10 38.7 0.1 0.062 12.7 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX70202.1 - 1.8e-07 31.7 1.0 0.0018 18.7 0.0 2.8 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX70202.1 - 2.1e-06 27.7 0.0 0.012 15.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ORX70202.1 - 4.8e-06 26.2 0.0 0.033 13.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 ORX70202.1 - 5.4e-06 26.7 0.1 0.15 12.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ORX70202.1 - 6.5e-06 26.5 0.3 0.09 13.1 0.2 3.3 3 1 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 ORX70202.1 - 1e-05 25.5 0.2 0.13 12.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase NACHT PF05729.12 ORX70202.1 - 1.3e-05 25.1 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 ORX70202.1 - 2.1e-05 24.4 0.0 0.12 12.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ORX70202.1 - 0.0001 22.5 0.2 0.22 11.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 ORX70202.1 - 0.00015 21.8 0.0 0.78 9.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 ORX70202.1 - 0.00037 20.9 0.0 0.7 10.3 0.1 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ORX70202.1 - 0.00049 19.4 0.0 0.91 8.6 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 ORX70202.1 - 0.00057 20.4 1.3 1 9.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain ATPase_2 PF01637.18 ORX70202.1 - 0.002 18.1 0.2 1.5 8.6 0.0 2.9 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea TsaE PF02367.17 ORX70202.1 - 0.0021 18.0 0.0 0.86 9.6 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 ORX70202.1 - 0.0023 17.9 0.1 0.82 9.6 0.1 2.6 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 ORX70202.1 - 0.0023 17.7 0.0 0.11 12.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX70202.1 - 0.0049 16.4 0.0 0.58 9.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 ORX70202.1 - 0.0049 16.5 0.2 0.35 10.4 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ORX70202.1 - 0.0053 17.1 0.0 3.6 8.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_23 PF13476.6 ORX70202.1 - 0.0054 17.2 0.0 0.0054 17.2 0.0 4.2 5 0 0 5 5 4 1 AAA domain Roc PF08477.13 ORX70202.1 - 0.011 16.0 0.1 3.1 8.1 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 ORX70202.1 - 0.015 15.3 0.3 12 5.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF3584 PF12128.8 ORX70202.1 - 0.021 12.4 0.1 0.021 12.4 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3584) MobB PF03205.14 ORX70202.1 - 0.024 14.5 0.1 0.3 11.0 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.6 ORX70202.1 - 0.026 14.7 0.4 0.74 10.1 0.1 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Adeno_IVa2 PF02456.15 ORX70202.1 - 0.038 12.8 0.0 4.3 6.0 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein PduV-EutP PF10662.9 ORX70202.1 - 0.039 13.7 0.1 7.9 6.2 0.0 2.7 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ORX70202.1 - 0.046 13.2 0.1 0.44 10.0 0.1 2.5 3 0 0 3 3 3 0 ADP-ribosylation factor family Zeta_toxin PF06414.12 ORX70202.1 - 0.049 12.9 0.0 0.22 10.8 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 ORX70202.1 - 0.054 13.1 0.1 6.8 6.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 ORX70202.1 - 0.057 13.1 0.1 0.057 13.1 0.1 3.8 4 1 0 4 4 3 0 AAA ATPase domain Dynamin_N PF00350.23 ORX70202.1 - 0.067 13.3 0.6 12 5.9 0.0 3.5 3 0 0 3 3 3 0 Dynamin family MeaB PF03308.16 ORX70202.1 - 0.076 12.0 0.9 9.5 5.1 0.0 3.0 4 0 0 4 4 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 ORX70202.1 - 0.092 12.3 0.3 2.3 7.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain PhetRS_B1 PF18262.1 ORX70202.1 - 0.099 12.9 0.0 6.3 7.1 0.0 2.9 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain DUF87 PF01935.17 ORX70202.1 - 0.1 12.7 3.7 2 8.4 0.0 3.4 4 0 0 4 4 3 0 Helicase HerA, central domain SRP54 PF00448.22 ORX70202.1 - 0.13 11.9 0.2 2.9 7.5 0.2 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_13 PF13166.6 ORX70202.1 - 0.48 9.0 5.3 7.2 5.1 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_17 PF13207.6 ORX70202.1 - 1.4 9.3 4.1 18 5.7 0.1 3.5 4 1 0 4 4 2 0 AAA domain SCO1-SenC PF02630.14 ORX70203.1 - 3.8e-47 159.6 0.0 5.9e-47 158.9 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 ORX70203.1 - 4.4e-05 23.4 0.0 0.00017 21.5 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX70203.1 - 0.031 14.0 0.0 0.076 12.7 0.0 1.7 1 1 0 1 1 1 0 Redoxin Ras PF00071.22 ORX70204.1 - 4.2e-56 189.0 0.1 4.9e-56 188.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX70204.1 - 1.2e-32 112.6 0.0 2.1e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX70204.1 - 1.8e-19 69.9 0.0 2.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX70204.1 - 1.2e-07 31.8 0.0 1.8e-07 31.2 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX70204.1 - 4.7e-06 26.3 0.1 1.7e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX70204.1 - 1.6e-05 24.4 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 ORX70204.1 - 0.0006 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein SRPRB PF09439.10 ORX70204.1 - 0.0013 18.2 0.1 0.0036 16.7 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ORX70204.1 - 0.0071 16.3 0.1 2 8.3 0.0 2.4 2 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ORX70204.1 - 0.048 13.4 0.1 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ORX70204.1 - 0.14 11.2 0.3 4.1 6.5 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit Cpn10 PF00166.21 ORX70205.1 - 1.7e-30 104.9 0.1 1.9e-30 104.8 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 ORX70206.1 - 9.3e-89 298.3 7.2 1.3e-88 297.8 7.2 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPSase_L_D2 PF02786.17 ORX70207.1 - 1.1e-114 381.3 0.5 4.5e-84 281.2 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 ORX70207.1 - 4e-49 165.7 0.0 9.5e-49 164.5 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 ORX70207.1 - 8.3e-46 156.2 0.0 4.5e-45 153.8 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 ORX70207.1 - 2.4e-43 147.7 0.0 6.8e-43 146.2 0.0 1.9 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 ORX70207.1 - 5.8e-39 133.2 0.1 1.6e-38 131.8 0.1 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 ORX70207.1 - 5.3e-28 98.1 0.1 1.4e-27 96.7 0.1 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Dala_Dala_lig_C PF07478.13 ORX70207.1 - 1.4e-17 63.9 0.5 1.3e-08 34.6 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 ORX70207.1 - 2.2e-17 63.0 0.0 2e-16 59.9 0.0 2.8 2 0 0 2 2 2 1 MGS-like domain ATP-grasp PF02222.22 ORX70207.1 - 1.6e-14 53.9 0.2 1.7e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 ORX70207.1 - 4.6e-10 39.3 0.1 7.2e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 ORX70207.1 - 3.7e-05 23.6 0.1 0.0045 16.8 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 ORX70207.1 - 7.6e-05 22.8 0.2 0.42 10.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 ORX70207.1 - 0.00021 20.9 0.0 0.0015 18.2 0.0 2.3 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.19 ORX70207.1 - 0.0015 18.3 0.4 0.53 10.0 0.0 3.4 4 0 0 4 4 4 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GSH-S_ATP PF02955.16 ORX70207.1 - 0.017 14.5 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Hydrolase_4 PF12146.8 ORX70208.1 - 1.9e-47 161.5 0.1 2.4e-47 161.2 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX70208.1 - 5.5e-16 59.0 0.3 1e-13 51.6 0.3 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX70208.1 - 5.6e-09 36.9 0.3 8.7e-09 36.3 0.3 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ORX70208.1 - 0.0026 17.4 0.0 0.0043 16.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ORX70208.1 - 0.012 15.1 0.1 0.65 9.4 0.1 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family LCAT PF02450.15 ORX70208.1 - 0.038 13.2 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Thioesterase PF00975.20 ORX70208.1 - 0.082 13.0 0.0 0.93 9.6 0.0 2.1 2 0 0 2 2 2 0 Thioesterase domain DUF1749 PF08538.10 ORX70208.1 - 0.092 11.8 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 ORX70209.1 - 8.5e-40 136.5 0.0 1.1e-39 136.1 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX70209.1 - 1.1e-20 74.4 0.3 4.2e-20 72.5 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX70209.1 - 5.6e-08 32.5 0.6 2e-05 24.2 0.6 2.6 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ORX70209.1 - 1.3e-07 32.4 0.0 1.9e-07 32.0 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ORX70209.1 - 4.8e-06 26.5 0.0 0.016 15.0 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 ORX70209.1 - 0.15 11.7 0.0 0.77 9.4 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) SR-25 PF10500.9 ORX70210.1 - 0.014 15.0 21.0 0.19 11.3 4.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 ORX70210.1 - 3.1 6.3 16.0 4 5.9 16.0 1.3 1 0 0 1 1 1 0 Macoilin family CCDC106 PF15794.5 ORX70210.1 - 6.7 6.4 21.5 7 6.3 7.8 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Hydrolase_4 PF12146.8 ORX70211.1 - 6.6e-18 64.8 0.3 8.5e-18 64.5 0.3 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX70211.1 - 1.8e-06 27.8 1.4 3e-06 27.1 1.4 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX70211.1 - 0.0011 19.6 0.6 0.0018 18.9 0.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.13 ORX70211.1 - 0.041 12.4 0.0 0.063 11.8 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II ubiquitin PF00240.23 ORX70212.1 - 5.6e-12 45.2 0.0 9.4e-12 44.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX70212.1 - 0.00051 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX70212.1 - 0.017 15.5 0.1 0.12 12.8 0.1 2.2 1 1 0 1 1 1 0 Ubiquitin-like domain Oxidored_FMN PF00724.20 ORX70213.1 - 5.7e-68 229.7 0.0 6.9e-68 229.4 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ORX70213.1 - 0.0081 15.3 0.0 0.015 14.4 0.0 1.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Ion_trans PF00520.31 ORX70215.1 - 3e-103 344.3 76.3 1.1e-31 110.0 3.6 5.1 5 0 0 5 5 5 5 Ion transport protein GPHH PF16905.5 ORX70215.1 - 0.057 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated HECW1_helix PF18436.1 ORX70215.1 - 0.2 11.8 0.5 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 PKD_channel PF08016.12 ORX70215.1 - 2.3 6.8 54.1 0.035 12.8 3.5 6.4 6 1 0 6 6 6 0 Polycystin cation channel zf-C2H2_aberr PF17017.5 ORX70216.1 - 0.00042 20.5 5.6 0.14 12.3 0.9 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ORX70216.1 - 0.001 19.4 12.8 0.063 13.8 0.6 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX70216.1 - 0.081 13.4 5.5 1.5 9.4 0.4 2.8 2 0 0 2 2 2 0 Zinc-finger double domain SLATT_1 PF18181.1 ORX70216.1 - 1.1 9.2 5.5 3.3 7.7 1.8 2.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 zf-C2H2_4 PF13894.6 ORX70216.1 - 4.6 8.3 16.1 6.3 7.9 0.9 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Ammonium_transp PF00909.21 ORX70216.1 - 4.7 5.8 8.2 8.9 4.9 8.2 1.3 1 0 0 1 1 1 0 Ammonium Transporter Family DNA_ligase_A_M PF01068.21 ORX70218.1 - 1.6e-57 194.4 0.0 3.4e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ORX70218.1 - 4.5e-41 141.1 0.2 8.1e-41 140.2 0.2 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ORX70218.1 - 2e-27 95.7 0.0 7.5e-27 93.8 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.6 ORX70218.1 - 0.00044 20.2 0.2 1.8 8.6 0.0 3.0 3 0 0 3 3 3 2 DNA ligase OB-like domain zf-HIT PF04438.16 ORX70219.1 - 2.1e-10 40.3 11.7 2.1e-10 40.3 11.7 1.9 2 0 0 2 2 2 1 HIT zinc finger DUF3837 PF12939.7 ORX70219.1 - 0.03 14.7 0.6 0.079 13.4 0.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) MADF_DNA_bdg PF10545.9 ORX70219.1 - 0.3 11.4 2.3 0.44 10.9 0.5 2.3 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like ELM2 PF01448.24 ORX70219.1 - 4.6 8.1 5.8 78 4.1 3.3 2.8 2 1 0 2 2 2 0 ELM2 domain zf-MYND PF01753.18 ORX70219.1 - 7.3 6.8 17.9 2.1 8.5 13.7 2.1 2 0 0 2 2 2 0 MYND finger Glyco_hydro_18 PF00704.28 ORX70220.1 - 3.9e-25 89.2 1.4 6.3e-24 85.3 1.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 PH_4 PF15404.6 ORX70221.1 - 2.6e-12 46.9 1.9 0.00051 19.9 0.0 3.6 2 1 0 2 2 2 2 Pleckstrin homology domain PH PF00169.29 ORX70221.1 - 8.7e-08 32.6 0.0 0.22 12.0 0.0 4.4 5 0 0 5 5 5 3 PH domain Apt1 PF10351.9 ORX70221.1 - 3.4 6.4 9.0 6.6 5.5 9.0 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4692 PF15763.5 ORX70221.1 - 5.7 7.4 8.1 11 6.4 8.1 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) TPK_catalytic PF04263.16 ORX70222.1 - 2.3e-30 105.1 0.0 3.9e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ORX70222.1 - 8.8e-19 67.0 0.0 1.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain MFS_1 PF07690.16 ORX70223.1 - 4.9e-46 157.3 57.3 8.5e-46 156.5 54.1 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX70223.1 - 1.7e-23 82.9 26.5 2.9e-23 82.1 26.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX70223.1 - 2e-14 53.3 12.0 2e-14 53.3 12.0 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter HlyIII PF03006.20 ORX70223.1 - 0.0032 17.2 0.1 0.0032 17.2 0.1 3.2 1 1 1 2 2 2 1 Haemolysin-III related Pox_A14 PF05767.12 ORX70223.1 - 0.18 12.0 4.5 1.1 9.5 0.3 3.7 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF4407 PF14362.6 ORX70223.1 - 0.67 9.2 6.2 8.5 5.6 2.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Nas2_N PF18265.1 ORX70224.1 - 5e-25 87.2 0.6 6.9e-25 86.8 0.6 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 ORX70224.1 - 2.8e-08 33.5 0.1 6.1e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ORX70224.1 - 9.1e-08 32.3 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 ORX70224.1 - 1.6e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 ORX70224.1 - 9.2e-05 22.7 0.0 0.00022 21.5 0.0 1.6 1 1 0 1 1 1 1 PDZ domain DUF3763 PF12592.8 ORX70224.1 - 0.58 10.3 4.1 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3763) Ribosomal_L29 PF00831.23 ORX70224.1 - 2.7 8.1 7.7 2.7 8.0 1.7 2.7 2 1 0 2 2 2 0 Ribosomal L29 protein RNA_lig_T4_1 PF09511.10 ORX70225.1 - 7.9e-76 254.8 0.0 1.4e-75 254.0 0.0 1.4 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 ORX70225.1 - 5.2e-38 130.8 0.0 1e-37 129.8 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_18 PF13238.6 ORX70225.1 - 0.0021 18.6 0.0 0.0054 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain tRNA_lig_CPD PF08302.11 ORX70225.1 - 0.0028 17.1 0.0 0.0041 16.6 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain Glyco_hydro_18 PF00704.28 ORX70226.1 - 2.1e-25 90.1 7.1 3e-24 86.3 7.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70226.1 - 2.3e-06 27.5 13.4 2.3e-06 27.5 13.4 3.5 2 1 1 3 3 3 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX70226.1 - 0.26 11.5 8.0 0.72 10.1 8.0 1.8 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Glyco_hydro_18 PF00704.28 ORX70227.1 - 2.3e-24 86.7 4.3 1.7e-23 83.8 4.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_18 PF00704.28 ORX70228.1 - 1.6e-23 83.9 7.1 1.5e-22 80.7 7.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_18 PF00704.28 ORX70229.1 - 6.9e-24 85.1 6.1 9e-23 81.5 6.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_2 PF00553.19 ORX70229.1 - 0.00026 21.2 0.2 0.00066 20.0 0.2 1.7 1 0 0 1 1 1 1 Cellulose binding domain SBDS PF01172.18 ORX70230.1 - 2.1e-13 50.1 0.0 3e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein FGAR-AT_N PF18076.1 ORX70230.1 - 0.011 15.8 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 0 Formylglycinamide ribonucleotide amidotransferase N-terminal DUF2694 PF10904.8 ORX70230.1 - 0.066 13.3 0.4 0.082 13.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) RPA_C PF08784.11 ORX70231.1 - 9.8e-12 45.5 0.5 3.1e-11 43.9 0.0 2.0 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 ORX70231.1 - 1.7e-06 27.9 0.1 3.4e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2e PF02091.15 ORX70231.1 - 0.15 11.3 0.1 0.57 9.4 0.0 1.8 2 0 0 2 2 2 0 Glycyl-tRNA synthetase alpha subunit CN_hydrolase PF00795.22 ORX70232.1 - 1.5e-52 178.5 0.1 1.7e-52 178.3 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.22 ORX70233.1 - 5.9e-45 153.6 0.4 6.8e-45 153.4 0.4 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.22 ORX70234.1 - 5.8e-58 196.3 0.0 6.5e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase QCR10 PF09796.9 ORX70235.1 - 4.5e-14 52.3 0.0 5.7e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Thr_synth_N PF14821.6 ORX70236.1 - 2.4e-27 95.0 0.0 1.6e-26 92.3 0.0 2.2 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 ORX70236.1 - 5.5e-15 55.6 0.1 2.1e-14 53.6 0.1 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MIF4G_like_2 PF09090.11 ORX70237.1 - 3.5e-45 154.6 0.3 6.5e-45 153.7 0.3 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 ORX70237.1 - 6.8e-39 133.6 0.1 1.6e-38 132.4 0.1 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 ORX70237.1 - 4.7e-10 39.4 0.0 1.8e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain PS_Dcarbxylase PF02666.15 ORX70238.1 - 5.2e-73 244.9 0.0 4.1e-71 238.7 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase NmrA PF05368.13 ORX70239.1 - 2.6e-25 89.4 0.0 3.4e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX70239.1 - 5e-14 52.6 0.1 1e-13 51.6 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ORX70239.1 - 0.0075 15.5 0.1 0.013 14.7 0.1 1.4 1 0 0 1 1 1 1 Male sterility protein Semialdhyde_dh PF01118.24 ORX70239.1 - 0.034 14.6 0.1 0.2 12.1 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX70239.1 - 0.057 13.5 0.3 0.18 12.0 0.1 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus AAA PF00004.29 ORX70240.1 - 1.1e-41 142.3 0.2 3.1e-34 118.2 0.0 2.5 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX70240.1 - 2e-12 47.8 0.3 6e-05 23.5 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 ORX70240.1 - 3.6e-10 40.0 0.5 1.6e-05 24.9 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX70240.1 - 6.8e-10 38.9 0.2 2.5e-06 27.3 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX70240.1 - 3.6e-08 33.8 0.2 0.0086 16.4 0.0 3.3 2 1 1 3 3 3 2 AAA domain NACHT PF05729.12 ORX70240.1 - 7.8e-08 32.4 1.2 0.028 14.3 0.2 3.5 4 0 0 4 4 3 2 NACHT domain IstB_IS21 PF01695.17 ORX70240.1 - 2.1e-07 30.8 0.1 0.0004 20.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX70240.1 - 7.4e-07 29.5 0.0 0.06 13.7 0.0 2.5 2 0 0 2 2 2 2 RNA helicase DUF815 PF05673.13 ORX70240.1 - 9e-07 28.3 0.0 0.0033 16.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 ORX70240.1 - 1.5e-06 27.9 0.2 4.3e-05 23.2 0.1 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_33 PF13671.6 ORX70240.1 - 1.8e-06 28.1 0.0 0.0044 17.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 ORX70240.1 - 2.9e-06 26.8 1.1 0.0088 15.4 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ORX70240.1 - 3e-06 26.7 0.2 0.00034 19.9 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_14 PF13173.6 ORX70240.1 - 4.5e-06 26.7 0.0 0.006 16.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ORX70240.1 - 6.2e-06 26.0 0.6 0.055 13.2 0.1 3.5 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 ORX70240.1 - 1.3e-05 24.8 0.0 0.07 12.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_3 PF07726.11 ORX70240.1 - 1.4e-05 24.9 0.1 0.0079 16.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ORX70240.1 - 1.8e-05 25.3 0.2 0.54 10.8 0.1 3.0 2 1 1 3 3 3 2 ABC transporter Zeta_toxin PF06414.12 ORX70240.1 - 5.6e-05 22.5 0.1 0.18 11.1 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.6 ORX70240.1 - 6e-05 22.7 0.0 0.2 11.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ORX70240.1 - 6.6e-05 22.9 0.0 0.27 11.2 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 ORX70240.1 - 0.00028 20.8 0.0 0.013 15.3 0.0 2.6 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_18 PF13238.6 ORX70240.1 - 0.00029 21.4 0.2 0.096 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX70240.1 - 0.00063 19.7 0.1 0.0044 16.9 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 ORX70240.1 - 0.00093 19.0 0.1 1.2 8.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 ORX70240.1 - 0.00093 19.4 0.1 0.065 13.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 ORX70240.1 - 0.0011 19.1 0.0 0.0079 16.3 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_29 PF13555.6 ORX70240.1 - 0.0014 18.3 0.0 0.9 9.3 0.1 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 ORX70240.1 - 0.0018 18.6 0.1 0.32 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX70240.1 - 0.0024 17.6 0.1 0.13 11.9 0.0 2.6 3 0 0 3 3 2 1 AAA domain ATPase PF06745.13 ORX70240.1 - 0.0025 17.2 0.1 0.45 9.8 0.0 2.4 2 1 0 2 2 2 1 KaiC NB-ARC PF00931.22 ORX70240.1 - 0.0026 17.0 0.2 0.41 9.8 0.0 2.6 3 0 0 3 3 3 1 NB-ARC domain DNA_pol3_delta2 PF13177.6 ORX70240.1 - 0.003 17.4 0.0 0.19 11.5 0.0 2.9 3 0 0 3 3 3 1 DNA polymerase III, delta subunit DUF2075 PF09848.9 ORX70240.1 - 0.0032 16.8 0.2 0.32 10.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 ORX70240.1 - 0.0036 16.5 0.1 0.46 9.6 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 AAA_17 PF13207.6 ORX70240.1 - 0.0065 16.9 0.1 1.6 9.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX70240.1 - 0.0071 16.7 0.5 0.47 10.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain Parvo_NS1 PF01057.17 ORX70240.1 - 0.0074 15.4 0.0 0.017 14.2 0.0 1.5 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 ORX70240.1 - 0.0074 16.2 0.5 3.9 7.4 0.1 2.6 3 0 0 3 3 2 0 NTPase TniB PF05621.11 ORX70240.1 - 0.011 15.2 0.0 2 7.8 0.0 2.9 3 0 0 3 3 3 0 Bacterial TniB protein Cytidylate_kin PF02224.18 ORX70240.1 - 0.017 14.9 0.0 0.88 9.3 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase Rad17 PF03215.15 ORX70240.1 - 0.018 15.0 0.0 8.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_11 PF13086.6 ORX70240.1 - 0.022 14.6 0.0 0.062 13.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 ORX70240.1 - 0.029 14.4 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 ORX70240.1 - 0.029 13.4 0.0 1.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Hpr_kinase_C PF07475.12 ORX70240.1 - 0.063 12.8 0.4 2 7.9 0.1 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain PhoH PF02562.16 ORX70240.1 - 0.073 12.5 0.0 0.59 9.6 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein CPT PF07931.12 ORX70240.1 - 0.092 12.6 0.4 0.51 10.2 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 ORX70240.1 - 0.096 12.6 0.1 12 5.8 0.1 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase CbiA PF01656.23 ORX70240.1 - 0.12 12.4 0.3 2.5 8.1 0.5 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Torsin PF06309.11 ORX70240.1 - 0.14 12.3 0.0 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 Torsin AFG1_ATPase PF03969.16 ORX70240.1 - 0.14 11.0 0.0 1 8.2 0.0 2.0 2 0 0 2 2 2 0 AFG1-like ATPase ParA PF10609.9 ORX70240.1 - 0.29 10.6 1.2 3.5 7.0 0.6 2.1 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase Pro_isomerase PF00160.21 ORX70241.1 - 1e-48 165.6 0.0 1.2e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase_fungal PF17667.1 ORX70242.1 - 2.9e-53 181.1 0.5 2.6e-28 98.9 0.0 2.7 3 0 0 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX70242.1 - 0.0014 18.0 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ORX70242.1 - 0.049 13.6 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1635 PF07795.11 ORX70242.1 - 0.38 10.6 1.9 0.69 9.7 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Succ_DH_flav_C PF02910.20 ORX70243.1 - 0.11 12.5 2.2 0.16 12.0 2.2 1.4 1 1 0 1 1 1 0 Fumarate reductase flavoprotein C-term SSXT PF05030.12 ORX70244.1 - 3.9e-10 39.2 1.0 9.4e-10 38.0 1.0 1.6 1 0 0 1 1 1 1 SSXT protein (N-terminal region) RGS PF00615.19 ORX70244.1 - 0.047 13.9 0.8 0.17 12.1 0.5 2.0 1 1 1 2 2 2 0 Regulator of G protein signaling domain tRNA-synt_His PF13393.6 ORX70245.1 - 9.4e-40 136.8 0.0 1.5e-39 136.1 0.0 1.3 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 ORX70245.1 - 4.1e-16 59.5 0.0 6.3e-15 55.6 0.0 2.7 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX70245.1 - 0.00023 21.2 0.3 0.0032 17.6 0.2 2.6 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2 PF00152.20 ORX70245.1 - 0.011 14.8 0.1 0.34 9.9 0.1 2.7 1 1 0 1 1 1 0 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 ORX70245.1 - 0.11 11.9 0.0 0.97 8.9 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Atg14 PF10186.9 ORX70246.1 - 0.0025 16.9 9.6 0.0038 16.4 9.6 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 CorA PF01544.18 ORX70246.1 - 0.19 11.0 6.8 0.35 10.2 6.8 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF724 PF05266.14 ORX70246.1 - 0.23 11.3 10.5 0.42 10.4 10.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-C4H2 PF10146.9 ORX70246.1 - 0.66 10.2 12.4 1.1 9.6 12.0 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein FapA PF03961.13 ORX70246.1 - 0.71 8.4 6.8 1.1 7.8 6.8 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Sec8_exocyst PF04048.14 ORX70246.1 - 1.3 8.9 7.1 2.3 8.1 3.7 2.8 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain VPS38 PF17649.1 ORX70246.1 - 1.4 7.7 7.4 0.13 11.1 1.5 1.8 1 1 1 2 2 2 0 Vacuolar protein sorting 38 V_ATPase_I PF01496.19 ORX70246.1 - 1.4 6.7 6.5 1.8 6.4 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIVA PF05103.13 ORX70246.1 - 2.2 8.4 15.5 12 6.0 15.1 2.3 1 1 0 1 1 1 0 DivIVA protein DUF1664 PF07889.12 ORX70246.1 - 3 7.9 7.2 7 6.7 2.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1690 PF07956.11 ORX70246.1 - 3.4 8.1 12.0 2.3 8.7 9.8 1.9 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) DUF2203 PF09969.9 ORX70246.1 - 3.8 8.2 12.3 7.5 7.3 7.4 3.0 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 ORX70246.1 - 4.4 6.5 5.8 6.4 5.9 5.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein zf-C2HC5 PF06221.13 ORX70247.1 - 8.9e-14 51.2 8.6 1.5e-13 50.5 8.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-ANAPC11 PF12861.7 ORX70248.1 - 5.7e-43 144.9 10.8 6.8e-43 144.7 10.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ORX70248.1 - 8.2e-22 77.3 12.1 1.2e-21 76.7 12.1 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ORX70248.1 - 1.1e-05 25.6 15.4 0.00033 20.9 15.4 2.7 2 1 0 2 2 2 1 Ring finger domain Zn_ribbon_17 PF17120.5 ORX70248.1 - 0.007 16.0 12.3 0.011 15.4 11.4 1.8 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 ORX70248.1 - 0.042 13.7 12.8 0.2 11.5 12.8 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ORX70248.1 - 0.049 13.8 9.0 0.097 12.9 9.0 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 ORX70248.1 - 0.088 12.6 3.5 0.14 12.0 3.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ORX70248.1 - 0.24 11.5 13.6 0.48 10.5 13.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 ORX70248.1 - 0.55 10.2 15.0 5.1 7.2 15.2 2.5 1 1 1 2 2 2 0 zinc-RING finger domain RINGv PF12906.7 ORX70248.1 - 2.6 8.3 11.6 11 6.3 11.6 2.1 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4_2 PF13923.6 ORX70248.1 - 3.5 7.5 19.8 52 3.8 19.8 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX70248.1 - 8.9 6.2 14.4 58 3.5 14.4 2.2 1 1 0 1 1 1 0 RING-like zinc finger Fungal_trans PF04082.18 ORX70249.1 - 5.8e-12 45.2 0.1 1e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX70249.1 - 8.7e-07 29.0 12.6 1.9e-06 27.8 12.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RseC_MucC PF04246.12 ORX70249.1 - 6.4 6.7 0.0 6.4 6.7 0.0 3.1 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Zn_clus PF00172.18 ORX70250.1 - 2.7e-06 27.4 12.1 2.7e-06 27.4 12.1 1.8 1 1 1 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.21 ORX70251.1 - 3.4e-47 160.6 0.0 3.9e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UPF0167 PF03691.14 ORX70252.1 - 0.067 13.0 0.2 0.067 13.0 0.2 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0167) SSXT PF05030.12 ORX70253.1 - 4e-10 39.2 1.0 9.4e-10 38.0 1.0 1.6 1 0 0 1 1 1 1 SSXT protein (N-terminal region) RGS PF00615.19 ORX70253.1 - 0.048 13.9 0.8 0.17 12.1 0.5 2.0 1 1 1 2 2 2 0 Regulator of G protein signaling domain Zn_ribbon_17 PF17120.5 ORX70254.1 - 2.2e-11 43.2 10.6 5.1e-11 42.0 10.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 ORX70254.1 - 2.9e-07 31.1 7.6 0.0029 18.4 0.1 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70254.1 - 0.066 13.5 0.1 1.3 9.3 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain XPG_N PF00752.17 ORX70255.1 - 9.6e-24 83.8 0.0 2.1e-23 82.7 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ORX70255.1 - 3.8e-22 78.4 0.2 7.3e-22 77.5 0.2 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ORX70255.1 - 2.6e-05 23.8 0.2 4.3e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 XPG domain containing Peptidase_M32 PF02074.15 ORX70255.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase ABC_tran PF00005.27 ORX70256.1 - 4e-42 144.0 2.3 3.5e-23 82.6 0.0 4.0 3 1 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ORX70256.1 - 3.8e-15 55.9 2.5 2.6e-05 23.8 0.0 4.0 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX70256.1 - 1.4e-13 51.4 10.1 0.0001 22.3 0.0 4.9 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX70256.1 - 1.1e-08 35.1 0.1 0.0025 17.8 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX70256.1 - 1.4e-08 34.8 0.1 0.0047 17.0 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 ORX70256.1 - 1.5e-07 31.3 2.8 1.5e-07 31.3 2.8 1.8 2 0 0 2 2 1 1 ABC transporter AAA_29 PF13555.6 ORX70256.1 - 1.1e-06 28.2 0.1 0.022 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain NB-ARC PF00931.22 ORX70256.1 - 2.7e-05 23.5 0.0 0.09 11.9 0.0 2.5 2 1 0 2 2 2 2 NB-ARC domain AAA_28 PF13521.6 ORX70256.1 - 3.8e-05 24.0 1.1 0.26 11.5 0.0 3.6 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 ORX70256.1 - 5.1e-05 23.6 0.0 0.13 12.7 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA_16 PF13191.6 ORX70256.1 - 9.9e-05 22.8 3.1 0.049 14.0 0.0 3.4 3 1 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 ORX70256.1 - 0.00014 22.3 0.8 1 9.8 0.2 4.1 3 2 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ORX70256.1 - 0.00035 20.5 0.0 0.18 11.7 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ORX70256.1 - 0.00067 20.0 0.5 1.2 9.4 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 ORX70256.1 - 0.00073 20.1 10.6 1 9.8 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.6 ORX70256.1 - 0.00073 19.4 0.7 0.17 11.6 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 ORX70256.1 - 0.00083 19.4 0.2 5.8 7.0 0.0 3.8 4 0 0 4 4 4 0 AAA domain Dynamin_N PF00350.23 ORX70256.1 - 0.0011 19.0 0.1 0.31 11.1 0.1 2.9 2 1 0 2 2 2 1 Dynamin family DUF87 PF01935.17 ORX70256.1 - 0.0018 18.4 0.1 0.0018 18.4 0.1 3.4 4 0 0 4 4 4 1 Helicase HerA, central domain AAA_27 PF13514.6 ORX70256.1 - 0.0047 16.5 0.1 0.091 12.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX70256.1 - 0.0072 16.1 0.1 0.8 9.4 0.0 3.3 4 0 0 4 4 3 1 AAA domain MeaB PF03308.16 ORX70256.1 - 0.0074 15.3 0.2 1.9 7.4 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 ORX70256.1 - 0.0084 16.7 0.4 12 6.5 0.0 3.4 3 1 1 4 4 3 0 AAA domain AAA_25 PF13481.6 ORX70256.1 - 0.0096 15.5 2.1 5.2 6.6 0.0 3.9 5 0 0 5 5 4 1 AAA domain IstB_IS21 PF01695.17 ORX70256.1 - 0.012 15.3 0.3 0.8 9.4 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein NTPase_1 PF03266.15 ORX70256.1 - 0.013 15.5 0.3 15 5.4 0.0 3.5 3 0 0 3 3 3 0 NTPase DUF503 PF04456.12 ORX70256.1 - 0.024 14.5 2.2 1.7 8.5 0.0 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF503) AAA_7 PF12775.7 ORX70256.1 - 0.027 14.0 0.1 9.2 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 ORX70256.1 - 0.035 14.0 0.0 14 5.5 0.0 3.0 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Roc PF08477.13 ORX70256.1 - 0.045 14.0 0.1 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ORX70256.1 - 0.057 12.7 0.1 10 5.3 0.0 2.2 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 ORX70256.1 - 0.076 12.2 0.0 10 5.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 ORX70256.1 - 0.18 11.3 3.5 5.2 6.6 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_33 PF13671.6 ORX70256.1 - 0.37 11.0 6.4 5.8 7.1 0.0 4.1 3 2 0 3 3 3 0 AAA domain COX6B PF02297.17 ORX70258.1 - 8e-16 58.0 1.0 9.5e-16 57.8 1.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb GCK PF07802.11 ORX70258.1 - 0.26 11.8 3.3 0.94 9.9 3.2 1.8 1 1 0 1 1 1 0 GCK domain AMP-binding PF00501.28 ORX70259.1 - 3.5e-70 236.7 0.0 6.1e-70 235.9 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ORX70259.1 - 1.1e-66 224.6 0.0 2.5e-66 223.5 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 ORX70259.1 - 1.6e-14 54.0 0.2 6e-14 52.1 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 ORX70259.1 - 5.2e-11 43.4 0.1 6.8e-09 36.6 0.0 3.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Condensation PF00668.20 ORX70259.1 - 5.9e-11 41.7 0.8 7.5e-10 38.1 0.8 2.0 1 1 0 1 1 1 1 Condensation domain Epimerase PF01370.21 ORX70259.1 - 1.1e-09 38.2 0.0 2.4e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX70259.1 - 0.00056 19.0 0.0 0.0013 17.8 0.0 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ORX70259.1 - 0.0012 18.8 1.8 0.018 14.9 0.1 3.3 2 1 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ORX70259.1 - 0.17 11.2 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase STI1 PF17830.1 ORX70261.1 - 0.00063 19.6 4.5 0.23 11.4 0.2 2.6 2 0 0 2 2 2 2 STI1 domain DUF1641 PF07849.11 ORX70261.1 - 0.0016 18.3 0.2 0.0037 17.1 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1641) SH3BGR PF04908.15 ORX70261.1 - 0.043 14.0 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DnaI_N PF07319.11 ORX70261.1 - 0.12 13.1 0.0 0.2 12.3 0.0 1.5 1 1 0 1 1 1 0 Primosomal protein DnaI N-terminus RRM_1 PF00076.22 ORX70262.1 - 2.4e-08 33.7 0.0 3.9e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TP_methylase PF00590.20 ORX70263.1 - 3.1e-47 161.2 0.5 6e-47 160.3 0.5 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 ORX70263.1 - 7.4e-31 106.7 0.1 1.7e-30 105.5 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 ORX70263.1 - 4.1e-20 71.2 0.0 9.1e-20 70.1 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 ORX70263.1 - 4.2e-08 32.5 0.1 4.2e-08 32.5 0.1 1.8 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central AlaDh_PNT_C PF01262.21 ORX70263.1 - 0.0017 17.7 0.0 0.0046 16.3 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF3168 PF11367.8 ORX70263.1 - 0.016 15.4 0.9 0.057 13.6 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3168) Brix PF04427.18 ORX70264.1 - 2.8e-42 145.0 0.0 3.8e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain Pkinase_fungal PF17667.1 ORX70265.1 - 7.4e-52 176.5 3.7 2.6e-28 98.9 0.0 3.0 3 1 1 4 4 4 2 Fungal protein kinase Pkinase PF00069.25 ORX70265.1 - 0.004 16.5 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ORX70265.1 - 0.064 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family SSXT PF05030.12 ORX70267.1 - 4.2e-10 39.1 1.0 9.4e-10 38.0 1.0 1.5 1 0 0 1 1 1 1 SSXT protein (N-terminal region) RGS PF00615.19 ORX70267.1 - 0.052 13.8 0.4 0.21 11.9 0.1 1.9 1 1 1 2 2 2 0 Regulator of G protein signaling domain LRR_8 PF13855.6 ORX70268.1 - 5.4e-12 45.3 3.3 1.5e-07 31.0 2.9 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ORX70268.1 - 9e-11 41.8 5.8 0.00057 20.2 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX70268.1 - 0.0032 17.8 10.4 3.5 8.5 1.9 5.2 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_3 PF07725.12 ORX70268.1 - 0.007 16.2 3.1 0.038 13.9 0.3 2.6 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_9 PF14580.6 ORX70268.1 - 0.013 15.0 1.5 0.072 12.6 0.5 2.1 1 1 1 2 2 2 0 Leucine-rich repeat FlaC_arch PF05377.11 ORX70269.1 - 0.13 12.7 0.1 0.34 11.3 0.1 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Lipase_3 PF01764.25 ORX70270.1 - 9.6e-07 28.8 0.0 3e-06 27.2 0.0 1.8 1 1 1 2 2 2 1 Lipase (class 3) UPF0227 PF05728.12 ORX70270.1 - 0.0074 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 ORX70270.1 - 0.016 14.5 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX70270.1 - 0.033 14.8 0.0 0.033 14.8 0.0 2.8 2 1 0 3 3 3 0 Alpha/beta hydrolase family DUF2974 PF11187.8 ORX70270.1 - 0.087 12.4 0.1 0.39 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 ORX70270.1 - 0.19 11.4 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_S10 PF00450.22 ORX70271.1 - 3.2e-94 316.7 0.1 4.1e-94 316.4 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Sec66 PF09802.9 ORX70272.1 - 3.3e-45 153.9 0.9 5.6e-45 153.1 0.9 1.3 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Di19_C PF14571.6 ORX70272.1 - 0.047 14.2 1.5 0.59 10.7 0.1 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Aminotran_4 PF01063.19 ORX70275.1 - 3.4e-05 23.8 0.0 5.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV Aminotran_4 PF01063.19 ORX70276.1 - 8.9e-20 71.5 0.0 5.4e-19 68.9 0.0 1.9 1 1 0 1 1 1 1 Amino-transferase class IV SMN PF06003.12 ORX70277.1 - 0.76 9.0 9.5 0.17 11.2 4.3 2.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) GATA PF00320.27 ORX70278.1 - 1.7e-10 40.3 5.0 1.7e-10 40.3 5.0 1.9 2 0 0 2 2 2 1 GATA zinc finger zf-AD PF07776.15 ORX70278.1 - 0.31 11.3 2.8 0.21 11.9 0.5 1.9 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) DZR PF12773.7 ORX70278.1 - 3.5 7.7 14.3 0.72 9.9 6.7 2.5 1 1 1 2 2 2 0 Double zinc ribbon PXA PF02194.15 ORX70279.1 - 2.9e-44 151.2 0.0 8.2e-44 149.7 0.0 1.8 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 ORX70279.1 - 1.7e-06 28.6 0.0 4.6e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Sorting nexin C terminal Frataxin_Cyay PF01491.16 ORX70280.1 - 1.6e-36 124.7 0.0 1.8e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain GMP_synt_C PF00958.22 ORX70281.1 - 3.5e-46 155.2 0.1 6.5e-46 154.3 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 ORX70281.1 - 1.9e-35 122.4 0.0 2.9e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 ORX70281.1 - 3e-10 39.6 0.0 3.9e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 ORX70281.1 - 3.1e-10 40.2 0.0 8.1e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase C26 tRNA_Me_trans PF03054.16 ORX70281.1 - 0.0036 16.1 0.1 0.0064 15.3 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 ORX70281.1 - 0.0043 16.7 0.1 0.0073 15.9 0.1 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 ORX70281.1 - 0.0064 16.0 0.0 0.029 13.9 0.0 1.9 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 ORX70281.1 - 0.078 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 PP-loop family HOASN PF14515.6 ORX70281.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices Rtf2 PF04641.12 ORX70282.1 - 5.4e-71 239.0 0.5 6.1e-71 238.8 0.5 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 ORX70282.1 - 0.00056 20.0 0.1 0.0018 18.4 0.0 1.8 1 1 1 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ORX70282.1 - 0.0019 18.0 0.7 1.1 9.2 0.0 2.6 2 1 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ORX70282.1 - 2.5 8.2 4.9 31 4.7 0.3 3.1 3 0 0 3 3 3 0 RING-type zinc-finger zf-C2H2 PF00096.26 ORX70285.1 - 4.8e-15 55.1 8.1 5.9e-08 32.8 2.0 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX70285.1 - 6e-11 42.2 6.6 2.3e-06 27.9 1.2 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX70285.1 - 5.6e-08 32.9 0.5 6.4e-06 26.4 0.2 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 ORX70285.1 - 1.1e-07 31.9 14.0 1.9e-05 24.8 1.1 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX70285.1 - 8.5e-07 28.8 3.0 0.00012 21.9 0.2 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX70285.1 - 5.2e-06 26.1 3.9 0.022 14.5 0.4 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ORX70285.1 - 1.2e-05 25.4 0.5 0.00087 19.5 0.1 2.3 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX70285.1 - 0.00012 21.8 1.4 0.17 11.7 0.3 2.3 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 ORX70285.1 - 0.00019 21.2 3.4 0.0084 16.0 0.2 2.4 2 1 0 2 2 2 2 zinc-finger of a C2HC-type zf-BED PF02892.15 ORX70285.1 - 0.00048 20.1 3.9 0.087 12.9 0.6 2.1 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_2 PF12756.7 ORX70285.1 - 0.0042 17.4 0.8 0.6 10.5 0.2 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 ORX70285.1 - 0.038 13.6 0.2 0.54 9.9 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn_ribbon_SprT PF17283.2 ORX70285.1 - 0.088 12.7 1.6 4.3 7.3 0.3 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain R3H PF01424.22 ORX70286.1 - 0.00067 19.6 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 R3H domain Y_phosphatase2 PF03162.13 ORX70287.1 - 4.4e-37 127.2 0.0 5.7e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX70287.1 - 0.0001 22.0 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase D5_N PF08706.11 ORX70287.1 - 0.015 15.6 0.0 0.19 12.0 0.0 2.2 2 1 1 3 3 3 0 D5 N terminal like Y_phosphatase3 PF13350.6 ORX70287.1 - 0.04 13.9 0.0 0.21 11.5 0.0 1.9 1 1 0 1 1 1 0 Tyrosine phosphatase family WD40 PF00400.32 ORX70288.1 - 2.2e-19 69.4 14.4 5e-08 33.5 0.0 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70288.1 - 1.2e-09 38.3 0.7 0.048 14.0 0.1 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 ORX70288.1 - 4.6e-06 25.9 0.0 5.7e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Coatomer WD associated region Ge1_WD40 PF16529.5 ORX70288.1 - 1e-05 24.7 0.0 0.00061 18.9 0.0 2.5 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX70288.1 - 1.7e-05 24.3 0.0 9.2e-05 21.9 0.0 1.9 1 1 1 2 2 2 1 WD40-like domain Colicin_Ia PF11504.8 ORX70288.1 - 0.06 13.5 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Colicin Ia PQQ_2 PF13360.6 ORX70288.1 - 0.13 11.8 4.5 6.3 6.3 4.3 2.6 1 1 0 1 1 1 0 PQQ-like domain Actin PF00022.19 ORX70289.1 - 2.5e-76 256.9 0.0 3.6e-75 253.1 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ORX70289.1 - 0.026 13.4 0.1 0.11 11.2 0.0 1.8 2 0 0 2 2 2 0 MreB/Mbl protein PilM_2 PF11104.8 ORX70289.1 - 0.029 13.4 0.1 0.32 10.0 0.0 2.0 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; CorA PF01544.18 ORX70290.1 - 0.011 15.0 1.0 0.017 14.4 1.0 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Peptidase_M36 PF02128.15 ORX70291.1 - 3.8e-148 493.6 1.4 5.1e-148 493.2 1.4 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX70291.1 - 7.6e-12 44.9 0.2 1.6e-11 43.8 0.2 1.6 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX70291.1 - 0.0005 20.0 0.0 0.00097 19.0 0.0 1.5 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain IMS PF00817.20 ORX70292.1 - 1.7e-43 148.2 0.0 4.1e-43 147.0 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 ORX70292.1 - 2e-05 24.1 0.0 4.7e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger HAD PF12710.7 ORX70293.1 - 5.7e-21 75.8 0.1 3.6e-20 73.2 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX70293.1 - 2e-18 67.5 0.5 3.8e-18 66.6 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SPX PF03105.19 ORX70293.1 - 1.5e-12 48.2 4.0 1.1e-06 28.9 0.1 3.1 3 0 0 3 3 3 2 SPX domain Hydrolase_3 PF08282.12 ORX70293.1 - 4.2e-09 36.5 0.6 7.9e-08 32.3 0.1 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase ACT_6 PF13740.6 ORX70293.1 - 2.3e-08 33.9 0.1 7.2e-08 32.3 0.1 1.9 1 0 0 1 1 1 1 ACT domain Put_Phosphatase PF06888.12 ORX70293.1 - 2.1e-05 24.0 0.0 0.006 16.0 0.0 2.4 2 0 0 2 2 2 2 Putative Phosphatase HAD_2 PF13419.6 ORX70293.1 - 0.00087 19.4 0.1 0.0095 16.0 0.1 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF705 PF05152.12 ORX70293.1 - 0.062 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Pkinase_fungal PF17667.1 ORX70294.1 - 6.3e-52 176.7 0.0 1.3e-49 169.1 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 ORX70294.1 - 0.12 11.7 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase_fungal PF17667.1 ORX70296.1 - 4.5e-59 200.3 0.0 1.3e-30 106.5 0.0 2.4 1 1 0 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 ORX70296.1 - 8.1e-05 22.1 0.0 0.00033 20.1 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain APH PF01636.23 ORX70296.1 - 0.061 13.2 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX70296.1 - 0.067 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 ORX70296.1 - 0.14 11.4 0.1 0.7 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase Ctf8 PF09696.10 ORX70297.1 - 6.2e-09 36.3 0.5 7.6e-08 32.8 0.2 2.4 1 1 1 2 2 2 1 Ctf8 GbpC PF08363.10 ORX70297.1 - 0.0088 15.5 0.0 0.0088 15.5 0.0 1.0 1 0 0 1 1 1 1 Glucan-binding protein C DUF410 PF04190.13 ORX70298.1 - 4.1e-50 171.0 0.1 6.2e-50 170.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF410) NRBF2_MIT PF17169.4 ORX70298.1 - 0.029 14.6 0.5 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 CxC5 PF18718.1 ORX70298.1 - 0.11 12.6 0.1 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 CxC5 like cysteine cluster associated with KDZ transposases DeoC PF01791.9 ORX70299.1 - 9.3e-14 51.6 0.7 1.2e-13 51.2 0.7 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase PseudoU_synth_1 PF01416.20 ORX70300.1 - 1.9e-15 57.2 0.0 9.4e-12 45.4 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 ORX70300.1 - 0.03 14.2 0.1 0.051 13.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) RNA_pol_Rpb5_N PF03871.14 ORX70300.1 - 0.067 13.8 0.9 0.36 11.4 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain polyprenyl_synt PF00348.17 ORX70301.1 - 9.4e-69 231.3 0.1 1.1e-68 231.1 0.1 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase tRNA_int_endo PF01974.17 ORX70302.1 - 9.4e-22 76.9 0.1 1.8e-21 76.0 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 ORX70302.1 - 0.0056 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain NAD_binding_5 PF07994.12 ORX70303.1 - 4.6e-143 476.4 0.0 5.4e-143 476.2 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ORX70303.1 - 5e-46 155.5 0.1 8.8e-46 154.6 0.1 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase CsbD PF05532.12 ORX70304.1 - 0.027 14.3 0.3 0.087 12.7 0.4 1.8 2 0 0 2 2 2 0 CsbD-like MFS_1 PF07690.16 ORX70306.1 - 1.1e-27 97.0 43.5 1.1e-27 97.0 43.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 ORX70307.1 - 1e-30 106.9 56.3 1.9e-21 76.4 35.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70307.1 - 0.0022 16.9 36.7 0.05 12.5 7.7 3.3 2 2 1 3 3 3 3 Sugar (and other) transporter Phage_holin_2_3 PF16080.5 ORX70307.1 - 0.038 13.8 0.0 0.17 11.6 0.0 2.2 1 0 0 1 1 1 0 Bacteriophage holin family HP1 4HBT PF03061.22 ORX70307.1 - 0.14 12.6 0.4 2.2 8.7 0.1 2.4 2 0 0 2 2 2 0 Thioesterase superfamily FixQ PF05545.11 ORX70307.1 - 0.99 9.4 0.0 0.99 9.4 0.0 3.0 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ Cwf_Cwc_15 PF04889.12 ORX70308.1 - 4.6e-64 216.5 23.7 4.6e-64 216.5 23.7 3.3 5 1 0 5 5 5 1 Cwf15/Cwc15 cell cycle control protein F1F0-ATPsyn_F PF10791.9 ORX70308.1 - 5.7e-13 49.1 0.4 4e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi TPR_12 PF13424.6 ORX70308.1 - 8.4e-05 22.8 7.8 0.00022 21.5 0.4 3.2 1 1 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.31 ORX70308.1 - 0.0014 18.7 0.3 0.012 15.7 0.0 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 ORX70308.1 - 0.0036 17.1 8.9 0.041 13.7 1.5 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX70308.1 - 0.041 14.0 11.4 0.75 10.1 1.7 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX70308.1 - 0.55 10.2 12.0 2.9 7.9 1.3 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat Peptidase_S39 PF02122.15 ORX70309.1 - 0.03 13.9 3.6 3.5 7.1 0.1 3.0 2 1 1 3 3 3 0 Peptidase S39 IMUP PF15761.5 ORX70309.1 - 0.19 12.4 0.2 0.19 12.4 0.2 5.1 5 0 0 5 5 5 0 Immortalisation up-regulated protein RRM_1 PF00076.22 ORX70310.1 - 1.5e-14 53.6 0.1 2.7e-11 43.1 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IMPDH PF00478.25 ORX70311.1 - 5.9e-133 443.1 2.5 6.9e-133 442.9 2.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ORX70311.1 - 1.6e-15 57.2 1.2 3.8e-09 36.9 0.1 2.6 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 ORX70311.1 - 3.2e-09 36.7 8.1 5.5e-05 22.7 4.8 2.6 2 1 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 ORX70311.1 - 1.8e-07 30.9 3.9 8.6e-06 25.4 3.9 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 ORX70311.1 - 2.9e-06 26.5 1.5 5.8e-06 25.6 1.5 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ThiG PF05690.14 ORX70311.1 - 0.0022 17.4 0.5 0.0022 17.4 0.5 1.9 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG YpsA PF06908.11 ORX70311.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family AMP-binding PF00501.28 ORX70312.1 - 1.6e-94 316.9 0.0 2e-94 316.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX70312.1 - 1.6e-13 51.4 0.0 4.7e-13 49.9 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Tma16 PF11176.8 ORX70313.1 - 9.2e-35 119.7 0.5 1.3e-34 119.2 0.5 1.2 1 0 0 1 1 1 1 Translation machinery-associated protein 16 DUF5572 PF17733.1 ORX70314.1 - 2.9e-12 46.2 4.9 5.5e-12 45.3 1.5 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5572) HEM4 PF02602.15 ORX70315.1 - 3.2e-27 95.4 0.0 7e-27 94.3 0.0 1.5 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD YtxH PF12732.7 ORX70316.1 - 0.00042 20.8 12.6 0.016 15.8 3.5 2.1 1 1 1 2 2 2 2 YtxH-like protein DUF883 PF05957.13 ORX70316.1 - 0.00068 20.2 14.4 0.011 16.3 5.8 2.0 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) CsbD PF05532.12 ORX70316.1 - 0.01 15.7 3.0 0.01 15.7 3.0 2.4 1 1 1 2 2 2 0 CsbD-like DBINO PF13892.6 ORX70316.1 - 0.048 14.0 3.2 0.082 13.3 3.2 1.5 1 1 0 1 1 1 0 DNA-binding domain LEA_4 PF02987.16 ORX70316.1 - 0.11 12.5 28.1 0.4 10.8 6.0 2.7 1 1 1 2 2 2 0 Late embryogenesis abundant protein ApoO PF09769.9 ORX70316.1 - 0.24 11.4 0.7 0.84 9.6 0.7 1.8 1 1 0 1 1 1 0 Apolipoprotein O Tape_meas_lam_C PF09718.10 ORX70316.1 - 0.46 10.7 13.8 7.1 6.8 4.7 3.0 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) TMP_2 PF06791.13 ORX70316.1 - 1.3 8.7 11.9 1.3 8.6 11.9 1.0 1 0 0 1 1 1 0 Prophage tail length tape measure protein RRF PF01765.19 ORX70316.1 - 1.6 8.7 8.6 5.7 6.9 8.6 1.8 1 1 0 1 1 1 0 Ribosome recycling factor Coat_F PF07875.12 ORX70316.1 - 1.8 8.9 5.6 2.8 8.2 0.5 2.7 1 1 2 3 3 3 0 Coat F domain ATP-synt_B PF00430.18 ORX70316.1 - 2.3 8.3 15.3 4.6 7.3 15.3 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Uricase PF01014.18 ORX70317.1 - 5.5e-56 188.4 0.3 8.9e-33 113.3 0.5 2.1 2 0 0 2 2 2 2 Uricase Exo_endo_phos PF03372.23 ORX70318.1 - 5.6e-11 42.4 0.0 8.2e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 ORX70318.1 - 5.8e-10 39.2 0.0 1.4e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain DUF1573 PF07610.11 ORX70318.1 - 0.23 11.5 0.0 0.47 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) Fe-S_biosyn PF01521.20 ORX70319.1 - 1.1e-15 57.8 0.0 1.3e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.7 ORX70319.1 - 0.031 14.4 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) T4BSS_DotH_IcmK PF12293.8 ORX70319.1 - 0.16 11.2 0.0 0.23 10.7 0.0 1.4 1 1 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion KH_8 PF17903.1 ORX70320.1 - 2.5e-06 27.5 0.0 5.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 ORX70320.1 - 0.0005 19.8 0.5 0.0031 17.3 0.2 2.1 2 0 0 2 2 2 1 KH domain 60KD_IMP PF02096.20 ORX70321.1 - 2e-15 57.1 0.0 9.4e-15 54.9 0.0 1.8 1 1 0 1 1 1 1 60Kd inner membrane protein Robl_LC7 PF03259.17 ORX70322.1 - 8.6e-18 63.9 0.4 9.5e-18 63.8 0.4 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 ORX70322.1 - 0.0079 16.1 0.0 0.0097 15.8 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 ABATE PF07336.11 ORX70322.1 - 0.058 14.1 0.0 0.076 13.7 0.0 1.1 1 0 0 1 1 1 0 Putative stress-induced transcription regulator Gti1_Pac2 PF09729.9 ORX70323.1 - 3.1e-41 141.4 5.4 8.4e-38 130.3 0.0 3.1 2 1 1 3 3 3 2 Gti1/Pac2 family DUF1970 PF09301.10 ORX70324.1 - 0.086 13.1 0.4 0.21 11.9 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) Gti1_Pac2 PF09729.9 ORX70325.1 - 3.2e-43 147.9 0.7 7.8e-37 127.1 0.1 2.0 2 0 0 2 2 2 2 Gti1/Pac2 family 5-FTHF_cyc-lig PF01812.20 ORX70326.1 - 1e-45 155.9 0.0 1.2e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family UCH PF00443.29 ORX70327.1 - 1.9e-41 142.3 0.0 3.3e-41 141.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX70327.1 - 1.7e-11 44.3 0.2 7.7e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 ORX70327.1 - 2.1e-05 24.4 0.3 0.0024 17.7 0.0 2.9 2 0 0 2 2 2 1 A repeated domain in UCH-protein DUF2688 PF10892.8 ORX70327.1 - 0.046 13.2 0.0 0.17 11.3 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) Uricase PF01014.18 ORX70328.1 - 5.5e-56 188.4 0.3 8.9e-33 113.3 0.5 2.1 2 0 0 2 2 2 2 Uricase OPT PF03169.15 ORX70329.1 - 1.1e-40 139.9 23.4 1.1e-40 139.9 23.4 2.0 2 0 0 2 2 2 1 OPT oligopeptide transporter protein CBFB_NFYA PF02045.15 ORX70330.1 - 5e-30 103.9 8.4 5.7e-30 103.7 8.4 1.0 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B OPT PF03169.15 ORX70331.1 - 3.5e-165 551.1 48.1 3.9e-165 551.0 48.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF805 PF05656.14 ORX70331.1 - 0.0041 17.5 0.6 0.0041 17.5 0.6 3.9 3 1 0 3 3 3 1 Protein of unknown function (DUF805) DUF3093 PF11292.8 ORX70331.1 - 1.5 9.1 7.6 1 9.6 2.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3093) Sigma_M_inh PF17453.2 ORX70331.1 - 3.5 8.1 6.9 1.5 9.4 0.9 3.2 2 0 0 2 2 2 0 Sigma-M inhibitor OPT PF03169.15 ORX70333.1 - 7.1e-158 527.0 49.7 8.2e-158 526.8 49.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3093 PF11292.8 ORX70333.1 - 4.9 7.4 7.7 2.7 8.2 3.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) OPT PF03169.15 ORX70334.1 - 3.5e-164 547.8 49.2 4e-164 547.6 49.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Na_Pi_cotrans PF02690.15 ORX70334.1 - 0.32 11.1 2.4 24 5.0 0.0 3.2 2 1 1 3 3 3 0 Na+/Pi-cotransporter DUF4191 PF13829.6 ORX70334.1 - 0.5 9.7 4.5 0.68 9.2 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Na_Ca_ex PF01699.24 ORX70336.1 - 6.2e-42 143.1 37.5 1.4e-21 77.0 17.1 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Phage_cap_E PF03864.15 ORX70336.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein E UCH PF00443.29 ORX70337.1 - 3.4e-63 213.6 0.0 5.7e-63 212.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX70337.1 - 4.5e-15 56.0 0.0 1.4e-14 54.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 ORX70337.1 - 8.6e-13 48.5 0.4 1.6e-12 47.6 0.4 1.4 1 0 0 1 1 1 1 USP8 dimerisation domain Rhodanese PF00581.20 ORX70337.1 - 2.3e-06 28.1 0.0 8.5e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain zf-MIZ PF02891.20 ORX70337.1 - 0.12 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger IDO PF01231.18 ORX70338.1 - 2.4e-23 82.6 0.0 7.5e-23 81.0 0.0 1.7 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase RF-1 PF00472.20 ORX70339.1 - 2.6e-19 69.3 3.3 3.3e-19 68.9 3.3 1.1 1 0 0 1 1 1 1 RF-1 domain DUF3512 PF12024.8 ORX70339.1 - 0.033 13.7 0.5 0.041 13.4 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3512) XRN_M PF17846.1 ORX70339.1 - 0.038 12.9 1.0 0.042 12.8 1.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain PIG-L PF02585.17 ORX70340.1 - 4.4e-25 88.8 0.1 7.4e-25 88.1 0.1 1.4 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF4440 PF14534.6 ORX70340.1 - 0.00027 21.3 0.1 0.00044 20.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Pkinase_Tyr PF07714.17 ORX70341.1 - 4.9e-52 176.8 0.0 5.9e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ORX70341.1 - 9.3e-51 172.7 0.0 1.2e-50 172.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ORX70341.1 - 0.0056 16.6 0.4 0.019 14.9 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family SAP PF02037.27 ORX70341.1 - 0.0083 15.9 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 SAP domain DUF2753 PF10952.8 ORX70341.1 - 0.034 14.3 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) Haspin_kinase PF12330.8 ORX70341.1 - 0.053 12.5 0.0 0.085 11.8 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain AP3B1_C PF14796.6 ORX70341.1 - 0.055 13.7 0.0 16 5.7 0.0 2.4 2 0 0 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Pkinase_fungal PF17667.1 ORX70342.1 - 7e-59 199.6 0.0 1.8e-30 106.0 0.0 2.4 1 1 0 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 ORX70342.1 - 5e-05 22.8 0.0 0.00031 20.2 0.0 2.2 3 0 0 3 3 3 1 Protein kinase domain Kdo PF06293.14 ORX70342.1 - 0.065 12.6 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX70342.1 - 0.066 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ORX70342.1 - 0.13 11.5 0.0 0.69 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX70343.1 - 3.3e-51 174.3 0.0 4.5e-49 167.3 0.0 2.1 1 1 0 1 1 1 1 Fungal protein kinase HAD PF12710.7 ORX70344.1 - 6.9e-21 75.5 0.1 3.8e-20 73.1 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX70344.1 - 1.9e-18 67.6 0.5 3.9e-18 66.5 0.5 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SPX PF03105.19 ORX70344.1 - 2.1e-12 47.7 4.3 1.1e-06 28.9 0.1 3.2 3 0 0 3 3 3 2 SPX domain Hydrolase_3 PF08282.12 ORX70344.1 - 4.8e-09 36.3 0.6 8.2e-08 32.3 0.1 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase ACT_6 PF13740.6 ORX70344.1 - 2.6e-08 33.7 0.1 7.4e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 ACT domain Put_Phosphatase PF06888.12 ORX70344.1 - 2.2e-05 24.0 0.0 0.0062 16.0 0.0 2.4 2 0 0 2 2 2 2 Putative Phosphatase HAD_2 PF13419.6 ORX70344.1 - 0.00094 19.3 0.1 0.0099 16.0 0.1 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF705 PF05152.12 ORX70344.1 - 0.065 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF705) zf-RING_2 PF13639.6 ORX70346.1 - 1.3e-09 38.2 4.1 2e-09 37.6 4.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX70346.1 - 8.4e-06 25.5 3.4 1.3e-05 24.9 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX70346.1 - 2.4e-05 24.1 1.6 3.9e-05 23.4 1.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX70346.1 - 0.00024 20.8 3.4 0.00024 20.8 3.4 1.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 ORX70346.1 - 0.00085 19.2 2.1 0.0013 18.7 2.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX70346.1 - 0.0025 17.6 1.9 0.0042 16.9 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX70346.1 - 0.0057 16.9 5.8 0.018 15.3 5.9 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 ORX70346.1 - 0.018 14.9 1.1 0.036 14.0 1.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX70346.1 - 0.018 14.9 5.6 0.2 11.5 5.9 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ORX70346.1 - 0.027 14.5 0.9 0.027 14.5 0.9 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_4 PF14570.6 ORX70346.1 - 0.035 13.9 2.0 0.069 13.0 2.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ORX70346.1 - 0.066 13.3 1.2 0.14 12.3 1.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX70346.1 - 0.074 12.7 3.4 0.14 11.8 3.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type F-box-like PF12937.7 ORX70347.1 - 2.2e-06 27.4 0.6 3.9e-06 26.6 0.6 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX70347.1 - 0.0005 19.9 0.7 0.0011 18.8 0.7 1.5 1 0 0 1 1 1 1 F-box domain DUF4375 PF14300.6 ORX70347.1 - 0.005 17.1 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4375) Glyco_hydro_47 PF01532.20 ORX70348.1 - 4.8e-145 484.0 0.0 5.6e-145 483.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Response_reg PF00072.24 ORX70349.1 - 9e-19 67.7 0.0 7.9e-12 45.3 0.0 2.6 2 1 0 2 2 2 2 Response regulator receiver domain Pkinase_fungal PF17667.1 ORX70350.1 - 5.8e-55 186.7 2.0 2.9e-53 181.1 0.0 2.8 2 1 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 ORX70350.1 - 0.0013 18.1 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 ORX70350.1 - 0.018 14.6 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family GPP34 PF05719.11 ORX70351.1 - 3.7e-55 187.1 0.5 5e-55 186.7 0.5 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PHD PF00628.29 ORX70353.1 - 1.6e-11 43.9 52.2 3e-05 23.8 5.1 5.7 4 1 1 5 5 5 3 PHD-finger RAMA PF18755.1 ORX70353.1 - 7.4e-06 26.3 0.0 0.00011 22.5 0.0 2.8 2 1 0 2 2 2 1 Restriction Enzyme Adenine Methylase Associated 7tm_3 PF00003.22 ORX70354.1 - 2.4e-07 30.7 21.1 3.1e-07 30.4 21.1 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1764 PF08576.10 ORX70355.1 - 1e-17 64.9 3.5 1.1e-17 64.8 1.6 2.0 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) HMG_box PF00505.19 ORX70356.1 - 2.6e-26 91.8 7.5 7.6e-13 48.7 0.5 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX70356.1 - 3.6e-23 81.9 7.1 2.4e-12 47.3 1.4 2.5 2 0 0 2 2 2 2 HMG-box domain Arginase PF00491.21 ORX70357.1 - 1.4e-75 254.4 0.1 1.6e-75 254.2 0.1 1.0 1 0 0 1 1 1 1 Arginase family Skp1_POZ PF03931.15 ORX70358.1 - 1.9e-11 44.0 0.0 3.2e-11 43.2 0.0 1.4 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain 7tm_3 PF00003.22 ORX70359.1 - 1.6e-08 34.6 18.6 2.2e-08 34.1 18.6 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR YbhQ PF11076.8 ORX70359.1 - 0.63 10.1 4.0 0.57 10.2 0.6 2.4 3 0 0 3 3 3 0 Putative inner membrane protein YbhQ DUF3792 PF12670.7 ORX70359.1 - 2 8.6 7.2 2.1 8.6 4.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3792) 7tm_3 PF00003.22 ORX70360.1 - 2.4e-07 30.7 21.1 3.1e-07 30.4 21.1 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Zn_clus PF00172.18 ORX70361.1 - 0.00015 21.8 16.5 0.00023 21.2 16.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain U3_assoc_6 PF08640.11 ORX70362.1 - 1.6e-34 117.8 10.0 9.9e-32 108.9 2.8 3.1 3 0 0 3 3 3 2 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 ORX70362.1 - 2.2e-07 31.1 1.0 0.032 15.1 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX70362.1 - 0.00097 18.4 0.2 0.21 10.7 0.0 2.6 1 1 1 3 3 3 2 NRDE-2, necessary for RNA interference MutH PF02976.15 ORX70362.1 - 0.0035 17.3 0.0 0.0083 16.1 0.0 1.7 1 1 0 1 1 1 1 DNA mismatch repair enzyme MutH Rrp40_N PF18311.1 ORX70363.1 - 0.086 12.8 0.3 0.63 10.0 0.0 2.4 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain MFS_1 PF07690.16 ORX70364.1 - 2.7e-20 72.6 58.8 9.4e-17 61.0 35.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 ORX70365.1 - 2.5e-22 79.3 55.9 5.5e-16 58.4 34.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CPP1-like PF11833.8 ORX70365.1 - 0.021 14.5 1.2 0.021 14.5 1.2 2.8 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3533 PF12051.8 ORX70366.1 - 1.5e-33 116.2 4.8 1.9e-33 115.9 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) zf-C2H2 PF00096.26 ORX70367.1 - 6.8e-19 67.2 37.7 2.3e-06 27.7 1.1 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX70367.1 - 1.2e-13 50.8 32.8 6.7e-06 26.3 1.5 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX70367.1 - 3.5e-06 27.4 45.7 0.0059 17.4 1.3 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 ORX70367.1 - 0.00094 19.5 13.1 0.27 11.7 0.2 4.9 4 1 1 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 ORX70367.1 - 0.091 12.9 16.8 2 8.5 4.1 3.6 1 1 2 3 3 3 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 ORX70367.1 - 0.15 12.4 15.0 8.7 6.8 1.0 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX70367.1 - 0.16 12.6 20.3 0.24 12.1 0.7 4.5 2 1 3 5 5 5 0 FOXP coiled-coil domain zf-LYAR PF08790.11 ORX70367.1 - 0.85 9.6 8.9 4.4 7.3 0.1 4.1 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger CCAP PF11105.8 ORX70367.1 - 5.8 6.9 10.8 6.9 6.6 0.3 3.0 1 1 2 3 3 3 0 Arthropod cardioacceleratory peptide 2a Aa_trans PF01490.18 ORX70427.1 - 4e-13 48.9 18.3 1.6e-12 46.9 15.1 2.8 2 1 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX70427.1 - 6.8e-05 22.1 3.7 0.0001 21.5 3.7 1.2 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family DUF4029 PF13221.6 ORX70427.1 - 0.12 13.1 0.8 0.2 12.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4029) HXXEE PF13787.6 ORX70427.1 - 2.6 8.9 6.6 0.84 10.5 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif GATA PF00320.27 ORX70429.1 - 2.8e-17 62.0 0.4 3.4e-17 61.7 0.4 1.1 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX70429.1 - 0.0039 16.7 1.3 0.0048 16.4 1.3 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding Auto_anti-p27 PF06677.12 ORX70429.1 - 0.046 13.9 0.8 0.06 13.5 0.8 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Vps36-NZF-N PF16988.5 ORX70429.1 - 0.056 12.8 0.3 3.3 7.2 0.0 2.1 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-ribbon_3 PF13248.6 ORX70429.1 - 0.29 10.6 2.4 6.6 6.3 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.27 ORX70430.1 - 7e-27 92.7 22.3 1.1e-15 56.9 1.3 3.4 4 0 0 4 4 4 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX70430.1 - 6e-07 28.9 6.0 0.0015 18.0 0.1 2.7 2 0 0 2 2 2 2 TFIIB zinc-binding NMD3 PF04981.13 ORX70430.1 - 0.049 13.1 1.3 1.6 8.2 0.1 2.4 2 0 0 2 2 2 0 NMD3 family Auto_anti-p27 PF06677.12 ORX70430.1 - 0.079 13.1 7.9 0.21 11.8 0.9 2.9 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HNF-1_N PF04814.13 ORX70430.1 - 5.2 7.6 9.4 2.5 8.7 3.9 2.2 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus GATA PF00320.27 ORX70431.1 - 6.8e-27 92.8 22.3 1.1e-15 56.9 1.3 3.4 4 0 0 4 4 4 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX70431.1 - 5.8e-07 28.9 6.0 0.0014 18.0 0.1 2.7 2 0 0 2 2 2 2 TFIIB zinc-binding NMD3 PF04981.13 ORX70431.1 - 0.048 13.1 1.3 1.5 8.2 0.1 2.4 2 0 0 2 2 2 0 NMD3 family Auto_anti-p27 PF06677.12 ORX70431.1 - 0.077 13.2 7.9 0.21 11.8 0.9 2.9 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 ORX70431.1 - 7.6 6.7 9.2 7.4 6.8 0.1 3.4 3 0 0 3 3 3 0 Zinc ribbon domain Pyr_redox_2 PF07992.14 ORX70432.1 - 7.4e-53 179.7 0.0 9.2e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX70432.1 - 3.2e-13 50.0 0.0 1.4e-12 48.0 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX70432.1 - 0.0091 15.3 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX70432.1 - 0.14 11.7 0.5 1.5 8.3 0.0 2.4 2 1 0 3 3 3 0 FAD dependent oxidoreductase DsrC PF04358.13 ORX70432.1 - 0.15 12.6 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 DsrC like protein PI3_PI4_kinase PF00454.27 ORX70438.1 - 5.5e-49 167.2 0.0 7.4e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ORX70438.1 - 2.2e-15 56.2 0.1 3.7e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 FATC domain Pyr_redox_2 PF07992.14 ORX70439.1 - 1.5e-51 175.4 0.0 1.8e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX70439.1 - 1e-12 48.4 0.1 4.7e-12 46.3 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX70439.1 - 0.02 14.2 0.0 5.5 6.2 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Arg_decarbox_C PF17944.1 ORX70439.1 - 0.092 13.3 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension CoA_transf_3 PF02515.17 ORX70443.1 - 7.1e-127 423.5 0.0 8.4e-127 423.3 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III AIRC PF00731.20 ORX70446.1 - 7.6e-64 213.8 0.1 1.6e-63 212.8 0.1 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ORX70446.1 - 2.1e-56 190.2 0.0 3.4e-56 189.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 ORX70446.1 - 9.7e-19 66.8 0.0 1.8e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 ORX70446.1 - 2.6e-06 27.1 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain 2-Hacid_dh_C PF02826.19 ORX70446.1 - 0.022 14.2 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX70446.1 - 0.039 13.3 0.1 0.26 10.6 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain E1-E2_ATPase PF00122.20 ORX70450.1 - 4.1e-32 111.1 4.1 4.2e-32 111.1 0.9 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 ORX70450.1 - 4.2e-09 36.0 0.3 2.1e-08 33.7 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cyt_bd_oxida_II PF02322.15 ORX70450.1 - 0.13 11.6 2.1 0.24 10.7 0.8 1.8 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II Methyltransf_11 PF08241.12 ORX70451.1 - 6.4e-22 78.0 0.0 1.1e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70451.1 - 3.8e-21 75.6 0.0 6e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX70451.1 - 7.8e-15 54.8 0.0 1.2e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX70451.1 - 3.3e-13 49.7 0.0 4.6e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70451.1 - 1.8e-09 38.2 0.0 3.5e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX70451.1 - 1.2e-06 28.1 0.0 7.4e-05 22.2 0.0 2.1 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ORX70451.1 - 3e-06 27.2 0.0 4.3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 ORX70451.1 - 6.7e-05 22.0 0.0 9.4e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase MTS PF05175.14 ORX70451.1 - 6.9e-05 22.5 0.0 0.00037 20.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX70451.1 - 0.00037 20.0 0.0 0.0016 17.9 0.0 1.9 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.15 ORX70451.1 - 0.0045 16.9 0.0 0.0095 15.8 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase PCMT PF01135.19 ORX70451.1 - 0.0053 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 ORX70451.1 - 0.0058 16.2 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase FtsJ PF01728.19 ORX70451.1 - 0.015 15.4 0.0 0.032 14.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 ORX70451.1 - 0.019 14.3 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ADH_zinc_N PF00107.26 ORX70451.1 - 0.022 14.8 0.0 0.057 13.4 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TPMT PF05724.11 ORX70451.1 - 0.041 13.5 0.0 0.074 12.7 0.0 1.5 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 ORX70451.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) HlyIII PF03006.20 ORX70452.1 - 1e-49 169.3 18.3 1.4e-49 168.9 18.3 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF308 PF03729.13 ORX70452.1 - 0.022 15.1 0.5 0.022 15.1 0.5 3.9 4 1 0 4 4 4 0 Short repeat of unknown function (DUF308) VIT1 PF01988.19 ORX70452.1 - 0.93 9.3 9.2 0.24 11.2 5.1 2.3 1 1 1 2 2 2 0 VIT family HlyIII PF03006.20 ORX70453.1 - 1.7e-35 122.8 20.0 4.9e-34 118.0 20.0 2.1 1 1 0 1 1 1 1 Haemolysin-III related DUF3147 PF11345.8 ORX70453.1 - 0.34 11.3 4.6 0.47 10.8 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3147) DUF3165 PF11364.8 ORX70453.1 - 0.51 10.7 4.1 6 7.3 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3165) Methyltransf_11 PF08241.12 ORX70454.1 - 2.6e-19 69.7 0.0 4.1e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70454.1 - 1.9e-17 63.7 0.0 3.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX70454.1 - 9.3e-12 44.8 0.0 1.4e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX70454.1 - 8.6e-10 38.6 0.0 1.3e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70454.1 - 1e-08 35.8 0.0 1.6e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX70454.1 - 0.0002 21.0 0.0 0.0014 18.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX70454.1 - 0.00023 21.1 0.0 0.00038 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 ORX70455.1 - 2.7e-33 115.0 0.1 3.6e-32 111.3 0.1 2.2 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX70455.1 - 1e-15 58.6 0.1 2.4e-15 57.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70455.1 - 6.4e-07 30.0 0.0 1.7e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX70455.1 - 5.9e-05 22.9 0.0 9.2e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ORX70455.1 - 0.0001 22.1 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX70455.1 - 0.00039 20.1 0.0 0.00066 19.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX70455.1 - 0.0006 20.4 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ORX70455.1 - 0.0093 15.7 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DUF938 PF06080.12 ORX70455.1 - 0.0098 15.7 0.0 0.027 14.2 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF938) CmcI PF04989.12 ORX70455.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_12 PF08242.12 ORX70455.1 - 0.016 15.9 0.1 0.056 14.2 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 ORX70455.1 - 0.019 14.9 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 ORX70455.1 - 0.064 13.1 0.3 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 ORX70455.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 ORX70455.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase GCD14 PF08704.10 ORX70455.1 - 0.2 11.3 0.1 0.51 10.0 0.0 1.6 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_3 PF01596.17 ORX70456.1 - 9.7e-35 119.7 0.3 1.4e-34 119.1 0.3 1.3 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX70456.1 - 9.3e-15 55.6 0.0 1.3e-14 55.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70456.1 - 9.1e-06 25.5 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70456.1 - 0.00013 22.6 0.0 0.00029 21.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX70456.1 - 0.0018 18.1 0.0 0.0025 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ORX70456.1 - 0.0063 16.2 0.0 0.0091 15.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 DUF938 PF06080.12 ORX70456.1 - 0.0071 16.1 0.1 0.018 14.8 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF938) CmcI PF04989.12 ORX70456.1 - 0.0075 16.0 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_11 PF08241.12 ORX70456.1 - 0.017 15.7 0.0 0.027 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 ORX70457.1 - 4e-06 26.1 0.7 0.00063 19.0 0.1 2.0 1 1 1 2 2 2 2 O-methyltransferase PRAI PF00697.22 ORX70458.1 - 3.5e-46 157.4 0.0 1.7e-42 145.4 0.0 2.0 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase HlyIII PF03006.20 ORX70459.1 - 4e-50 170.6 25.8 5e-50 170.3 25.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related TMEM43 PF07787.12 ORX70459.1 - 0.088 12.2 0.9 0.28 10.5 0.9 1.8 1 0 0 1 1 1 0 Transmembrane protein 43 Tetraspanin PF00335.20 ORX70459.1 - 3.3 7.4 9.0 0.53 9.9 4.7 1.8 2 0 0 2 2 2 0 Tetraspanin family Ribosomal_S8 PF00410.19 ORX70460.1 - 2.4e-17 63.0 0.0 4.1e-16 59.1 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8 HlyIII PF03006.20 ORX70461.1 - 5.6e-55 186.5 17.2 2.1e-54 184.6 17.2 1.7 1 1 0 1 1 1 1 Haemolysin-III related DUF3337 PF11816.8 ORX70462.1 - 7.9e-29 100.7 0.0 2.6e-28 99.0 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 ORX70462.1 - 0.015 16.1 0.6 0.015 16.1 0.6 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat Sugar_tr PF00083.24 ORX70463.1 - 1.5e-78 264.7 20.4 1.9e-78 264.4 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX70463.1 - 1e-26 93.7 44.4 1.4e-19 70.2 7.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 ORX70463.1 - 0.0077 16.0 0.0 0.0077 16.0 0.0 2.5 2 1 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MFS_3 PF05977.13 ORX70463.1 - 0.97 7.7 13.0 0.11 10.9 1.2 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector Sugar_tr PF00083.24 ORX70464.1 - 1.9e-90 303.9 24.6 2.2e-90 303.7 24.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX70464.1 - 5.3e-24 84.8 49.5 8.9e-19 67.6 14.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF2398 PF09661.10 ORX70464.1 - 0.0093 15.3 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2398) Trp_oprn_chp PF09534.10 ORX70464.1 - 0.1 12.4 0.4 0.32 10.8 0.4 1.9 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ninjurin PF04923.12 ORX70464.1 - 0.18 11.8 2.8 0.59 10.1 2.8 1.9 1 0 0 1 1 1 0 Ninjurin Proteasome PF00227.26 ORX70466.1 - 1.3e-50 171.5 0.4 1.5e-50 171.3 0.4 1.0 1 0 0 1 1 1 1 Proteasome subunit F-box-like PF12937.7 ORX70467.1 - 5.2e-10 39.1 0.2 1.2e-09 37.9 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX70467.1 - 0.00039 20.2 0.1 0.0015 18.3 0.1 2.1 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ORX70467.1 - 0.0016 18.8 0.6 3.4 8.2 0.0 4.1 2 2 2 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX70467.1 - 0.069 12.9 0.2 2.7 7.8 0.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat Hc1 PF07432.13 ORX70468.1 - 4.4 7.7 13.4 0.66 10.4 6.9 2.3 2 0 0 2 2 2 0 Histone H1-like protein Hc1 TPMT PF05724.11 ORX70469.1 - 1.3e-26 93.6 0.0 8.1e-25 87.8 0.0 2.0 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 ORX70469.1 - 5.5e-06 26.3 0.0 1.2e-05 25.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70469.1 - 2.2e-05 25.1 0.1 5.8e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70469.1 - 0.0018 19.0 0.0 0.0034 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70469.1 - 0.012 16.2 0.0 0.034 14.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 ORX70469.1 - 0.075 12.6 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX70469.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 ORX70470.1 - 3.4e-12 46.5 0.1 1.5e-11 44.4 0.1 1.8 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 ORX70470.1 - 3.6e-05 24.4 0.0 5.1e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70470.1 - 0.0023 18.6 0.0 0.0036 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70470.1 - 0.14 12.8 0.0 0.24 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70470.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PPR_2 PF13041.6 ORX70471.1 - 0.00011 22.4 0.1 0.18 12.0 0.0 3.7 4 0 0 4 4 4 1 PPR repeat family PPR_3 PF13812.6 ORX70471.1 - 0.031 14.4 0.0 0.12 12.4 0.0 2.0 1 0 0 1 1 1 0 Pentatricopeptide repeat domain Peptidase_M22 PF00814.25 ORX70472.1 - 1.8e-89 300.0 0.0 2.2e-89 299.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ORX70472.1 - 0.001 18.8 0.0 0.033 13.9 0.0 2.1 2 0 0 2 2 2 2 Carbamoyltransferase N-terminus GLE1 PF07817.13 ORX70473.1 - 8.2e-48 162.8 2.5 1.2e-47 162.2 0.0 2.3 3 0 0 3 3 3 1 GLE1-like protein MA3 PF02847.17 ORX70473.1 - 5.6e-13 48.9 0.2 3.5e-12 46.3 0.2 2.2 1 1 0 1 1 1 1 MA3 domain ABC2_membrane PF01061.24 ORX70474.1 - 7.7e-50 169.2 44.7 2.3e-20 72.9 19.0 4.1 3 2 1 4 4 4 3 ABC-2 type transporter ABC_tran PF00005.27 ORX70474.1 - 3.2e-23 82.8 0.0 5.6e-12 46.3 0.0 3.7 3 1 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 ORX70474.1 - 4.1e-15 55.4 1.5 2.9e-07 30.3 0.1 3.1 2 0 0 2 2 2 2 CDR ABC transporter AAA_21 PF13304.6 ORX70474.1 - 1.1e-07 31.9 0.1 0.0038 17.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX70474.1 - 0.00013 21.6 0.4 0.00037 20.2 0.4 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX70474.1 - 0.00038 20.4 0.1 0.00095 19.1 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ORX70474.1 - 0.0032 16.9 0.0 2 7.8 0.0 2.6 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX70474.1 - 0.0045 17.5 2.3 0.088 13.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX70474.1 - 0.036 14.3 0.0 0.17 12.2 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 ORX70474.1 - 0.053 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ORX70474.1 - 0.099 12.2 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX70474.1 - 0.1 12.8 0.4 0.24 11.6 0.4 1.6 1 0 0 1 1 1 0 AAA domain ABC_trans_N PF14510.6 ORX70474.1 - 0.17 12.5 0.0 0.39 11.3 0.0 1.5 1 0 0 1 1 1 0 ABC-transporter N-terminal AAA_15 PF13175.6 ORX70474.1 - 0.2 11.3 0.1 10 5.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.6 ORX70474.1 - 0.21 12.0 0.7 0.33 11.4 0.1 1.6 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 ORX70474.1 - 0.27 10.8 0.3 0.48 10.0 0.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_S49 PF01343.18 ORX70475.1 - 4e-53 179.5 0.1 3.8e-35 121.1 0.0 3.1 3 0 0 3 3 3 2 Peptidase family S49 CLP_protease PF00574.23 ORX70475.1 - 0.0008 19.3 0.0 0.25 11.2 0.0 2.6 2 0 0 2 2 2 2 Clp protease DUF3396 PF11876.8 ORX70475.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3396) Amidase PF01425.21 ORX70476.1 - 5.5e-66 223.4 0.2 7.8e-57 193.2 0.2 2.1 2 0 0 2 2 2 2 Amidase PulG PF11773.8 ORX70477.1 - 0.15 11.9 0.2 0.15 11.9 0.2 1.7 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin PTPlike_phytase PF14566.6 ORX70481.1 - 0.087 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Sec7 PF01369.20 ORX70482.1 - 2.3e-56 190.4 0.1 1.3e-54 184.7 0.1 2.4 1 1 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ORX70482.1 - 0.31 10.9 3.2 0.29 11.0 0.3 2.3 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Ribosomal_L18 PF17135.4 ORX70483.1 - 1.1e-92 308.6 2.6 1.2e-92 308.5 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ORX70483.1 - 0.012 16.3 0.1 0.028 15.1 0.1 1.8 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Tra_M PF05261.11 ORX70483.1 - 0.16 12.0 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 TraM protein, DNA-binding WD40 PF00400.32 ORX70485.1 - 1e-14 54.6 9.0 0.00016 22.4 0.0 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70485.1 - 0.00042 20.5 0.0 0.25 11.6 0.0 3.9 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX70485.1 - 0.053 12.8 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 WD40-like domain TH1 PF04858.13 ORX70487.1 - 2.4e-76 257.6 0.0 3.2e-76 257.2 0.0 1.0 1 0 0 1 1 1 1 TH1 protein PH_4 PF15404.6 ORX70488.1 - 0.18 11.6 1.9 0.38 10.5 1.9 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Band_3_cyto PF07565.13 ORX70488.1 - 0.81 9.4 3.1 1.2 8.9 2.6 1.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain SSP160 PF06933.11 ORX70488.1 - 1.7 6.8 15.8 2.6 6.2 15.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Presenilin PF01080.17 ORX70488.1 - 2.2 6.9 7.4 3 6.5 7.4 1.1 1 0 0 1 1 1 0 Presenilin NDC10_II PF16787.5 ORX70489.1 - 3.6e-17 62.4 0.3 7.2e-17 61.4 0.3 1.4 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Apolipoprotein PF01442.18 ORX70489.1 - 4.6 7.1 6.1 3.1 7.6 0.7 3.0 4 0 0 4 4 4 0 Apolipoprotein A1/A4/E domain NDC10_II PF16787.5 ORX70490.1 - 2.9e-14 52.8 0.0 3.8e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Leu_zip PF15294.6 ORX70490.1 - 0.13 11.8 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Leucine zipper Trypsin PF00089.26 ORX70491.1 - 8.8e-37 127.0 4.2 3e-36 125.3 4.2 1.7 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX70491.1 - 3.1e-09 37.9 0.2 5.6e-09 37.1 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 ORX70491.1 - 3.7e-05 23.5 0.0 0.0039 16.8 0.0 2.2 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 DUF1986 PF09342.11 ORX70491.1 - 0.016 15.5 0.1 1.8 9.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1986) Kelch_5 PF13854.6 ORX70492.1 - 6.4e-18 64.3 1.0 1.3e-07 31.5 0.0 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ORX70492.1 - 8.2e-13 48.1 4.8 0.0055 16.7 0.1 5.7 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX70492.1 - 1e-12 47.5 0.2 1.5e-05 24.8 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ORX70492.1 - 2.9e-12 46.0 3.6 5.8e-07 29.0 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ORX70492.1 - 9e-09 35.4 16.0 1.1e-05 25.5 0.2 6.5 5 2 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX70492.1 - 5.6e-08 32.8 9.0 0.0013 18.9 0.1 5.3 4 2 1 5 5 5 2 Kelch motif Ubie_methyltran PF01209.18 ORX70493.1 - 4.2e-76 255.3 0.0 5.4e-76 255.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX70493.1 - 5.1e-12 46.3 0.0 9e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70493.1 - 7.5e-11 42.6 0.1 2.8e-10 40.8 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70493.1 - 3.9e-07 30.0 0.0 1.5e-06 28.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX70493.1 - 9.7e-07 28.8 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70493.1 - 8.3e-05 23.3 0.0 0.0003 21.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ORX70493.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Pribosyltran_N PF13793.6 ORX70494.1 - 1.7e-40 137.6 0.4 6e-40 135.8 0.1 2.1 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ORX70494.1 - 5.1e-25 88.6 0.7 5.4e-10 39.6 0.0 3.6 3 1 1 4 4 4 3 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ORX70494.1 - 4.8e-06 26.2 0.4 0.00026 20.5 0.1 3.1 2 2 0 2 2 2 1 Phosphoribosyl transferase domain Fer4_3 PF12798.7 ORX70494.1 - 0.56 11.3 1.7 1.1 10.4 1.7 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain Ribophorin_II PF05817.14 ORX70495.1 - 1.7e-17 63.3 0.0 3e-17 62.5 0.0 1.4 1 1 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II MadM PF03818.13 ORX70495.1 - 0.011 15.5 0.0 0.77 9.7 0.0 2.4 2 0 0 2 2 2 0 Malonate/sodium symporter MadM subunit DoxX PF07681.12 ORX70495.1 - 0.023 15.3 0.2 0.023 15.3 0.2 1.6 2 0 0 2 2 2 0 DoxX EMP24_GP25L PF01105.24 ORX70496.1 - 1e-38 133.1 0.1 1.2e-38 132.9 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pkinase PF00069.25 ORX70497.1 - 1.4e-69 234.4 0.0 1.6e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70497.1 - 7e-32 110.7 0.0 9e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ORX70497.1 - 1.2e-22 80.0 1.8 1.5e-22 79.7 0.5 1.8 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ORX70497.1 - 7.6e-08 32.6 0.0 1.8e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 ORX70497.1 - 6.9e-07 28.9 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX70497.1 - 6.5e-06 25.2 0.0 9.8e-06 24.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX70497.1 - 0.00019 20.9 0.1 0.00038 19.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX70497.1 - 0.012 15.5 0.1 0.016 15.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX70497.1 - 0.026 13.5 0.5 0.037 13.0 0.5 1.2 1 0 0 1 1 1 0 Haspin like kinase domain YopE_N PF09020.10 ORX70498.1 - 0.17 12.1 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 YopE, N terminal Virul_fac_BrkB PF03631.15 ORX70499.1 - 0.0071 16.0 3.0 0.0085 15.7 3.0 1.1 1 0 0 1 1 1 1 Virulence factor BrkB DUF2207 PF09972.9 ORX70499.1 - 0.031 13.1 0.9 0.041 12.7 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspanin PF00335.20 ORX70499.1 - 0.062 13.0 1.2 0.081 12.6 1.2 1.3 1 0 0 1 1 1 0 Tetraspanin family LapA_dom PF06305.11 ORX70499.1 - 0.09 12.6 5.2 0.37 10.6 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF1211 PF06736.11 ORX70499.1 - 0.14 12.6 1.8 0.78 10.2 1.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1211) Pox_A14 PF05767.12 ORX70499.1 - 0.31 11.2 5.2 23 5.2 0.1 2.9 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 DUF5305 PF17231.2 ORX70499.1 - 0.32 10.4 1.8 3.1 7.1 0.0 2.1 1 1 0 2 2 2 0 Family of unknown function (DUF5305) FixS PF03597.15 ORX70499.1 - 4.6 7.0 10.9 0.18 11.6 1.4 2.6 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Phage_holin_3_6 PF07332.11 ORX70500.1 - 0.0035 17.4 1.1 0.0056 16.7 1.1 1.4 1 1 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III LPG_synthase_TM PF03706.13 ORX70500.1 - 0.012 15.1 3.3 0.015 14.9 3.3 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Cadherin_C_2 PF16492.5 ORX70500.1 - 0.018 15.8 1.2 0.75 10.6 0.0 2.2 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal SLAC1 PF03595.17 ORX70500.1 - 0.069 12.4 1.5 0.23 10.7 1.5 1.7 1 1 0 1 1 1 0 Voltage-dependent anion channel DUF2207 PF09972.9 ORX70500.1 - 0.096 11.4 0.2 0.11 11.3 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ninjurin PF04923.12 ORX70500.1 - 0.11 12.4 1.3 0.19 11.7 1.3 1.6 1 1 0 1 1 1 0 Ninjurin Insulin_TMD PF17870.1 ORX70501.1 - 0.013 15.6 0.7 0.013 15.6 0.7 2.1 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment Phage_holin_3_6 PF07332.11 ORX70501.1 - 0.18 11.8 0.8 0.8 9.8 0.8 1.9 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III LapA_dom PF06305.11 ORX70501.1 - 0.65 9.9 2.3 7.9 6.4 0.0 2.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain MARVEL PF01284.23 ORX70502.1 - 0.0061 16.6 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 1 Membrane-associating domain Shisa PF13908.6 ORX70502.1 - 0.056 13.7 3.0 0.098 12.9 3.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PEMT PF04191.13 ORX70502.1 - 0.12 12.8 0.8 0.18 12.2 0.8 1.3 1 0 0 1 1 1 0 Phospholipid methyltransferase DUF4748 PF15932.5 ORX70502.1 - 0.19 11.5 1.8 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) STE3 PF02076.15 ORX70503.1 - 0.0034 16.6 0.1 0.0042 16.3 0.1 1.0 1 0 0 1 1 1 1 Pheromone A receptor Transferase PF02458.15 ORX70504.1 - 2.1e-22 79.4 0.0 1.1e-21 77.1 0.0 1.8 1 1 0 1 1 1 1 Transferase family DUF2157 PF09925.9 ORX70505.1 - 0.048 13.5 0.1 0.57 10.0 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) ETRAMP PF09716.10 ORX70505.1 - 0.6 10.2 3.6 0.61 10.2 0.3 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Beta-TrCP_D PF12125.8 ORX70506.1 - 0.054 13.4 0.1 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 D domain of beta-TrCP NDC10_II PF16787.5 ORX70508.1 - 2.7e-08 33.3 0.7 3.8e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Cnn_1N PF07989.11 ORX70508.1 - 0.087 13.0 2.2 0.19 11.9 2.2 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TRAM_LAG1_CLN8 PF03798.16 ORX70511.1 - 0.0017 18.1 0.1 0.0023 17.7 0.1 1.1 1 0 0 1 1 1 1 TLC domain FixQ PF05545.11 ORX70511.1 - 0.011 15.6 2.0 1.9 8.5 1.2 2.3 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ RTA1 PF04479.13 ORX70511.1 - 0.047 13.3 0.4 0.065 12.8 0.4 1.1 1 0 0 1 1 1 0 RTA1 like protein WBP-1 PF11669.8 ORX70511.1 - 0.078 13.6 0.3 0.16 12.6 0.3 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 Peptidase_A22B PF04258.13 ORX70511.1 - 0.1 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Signal peptide peptidase DUF2627 PF11118.8 ORX70511.1 - 0.59 10.7 2.4 2.1 9.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2627) DUF4131 PF13567.6 ORX70511.1 - 2.6 7.7 6.1 41 3.8 3.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 ORX70512.1 - 8.6e-07 29.3 2.8 8.6e-07 29.3 2.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Claudin_2 PF13903.6 ORX70512.1 - 0.039 13.7 0.1 0.046 13.5 0.1 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF3622 PF12286.8 ORX70512.1 - 0.16 12.3 0.3 0.27 11.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3622) DUF975 PF06161.11 ORX70513.1 - 0.00047 20.0 0.2 0.00057 19.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF975) DUF1673 PF07895.11 ORX70513.1 - 0.00055 19.7 3.1 0.00082 19.1 3.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1673) 7tm_7 PF08395.12 ORX70513.1 - 0.00072 18.9 0.5 0.00097 18.4 0.5 1.0 1 0 0 1 1 1 1 7tm Chemosensory receptor PIG-P PF08510.12 ORX70513.1 - 0.0019 18.1 0.1 0.0024 17.8 0.1 1.2 1 0 0 1 1 1 1 PIG-P Neur_chan_memb PF02932.16 ORX70513.1 - 0.0075 16.3 0.1 0.0097 16.0 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region GWT1 PF06423.12 ORX70513.1 - 0.039 14.1 0.3 0.053 13.6 0.3 1.2 1 0 0 1 1 1 0 GWT1 DHHC PF01529.20 ORX70513.1 - 0.12 12.5 2.4 0.21 11.7 2.4 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase Sid-5 PF17204.3 ORX70513.1 - 0.49 10.6 2.9 14 6.0 0.2 2.3 2 0 0 2 2 2 0 Sid-5 family 2TM PF13239.6 ORX70513.1 - 0.54 10.6 3.7 1.2 9.5 3.7 1.5 1 0 0 1 1 1 0 2TM domain DUF4131 PF13567.6 ORX70513.1 - 0.59 9.8 5.1 0.94 9.1 4.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2116 PF09889.9 ORX70513.1 - 1.4 9.0 3.6 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) OppC_N PF12911.7 ORX70513.1 - 4.6 7.3 11.6 0.43 10.6 1.7 2.4 1 1 1 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C FtsL PF04999.13 ORX70513.1 - 7 6.7 6.3 1.5 8.9 1.7 2.1 1 1 1 2 2 2 0 Cell division protein FtsL Pox_EPC_I2-L1 PF12575.8 ORX70513.1 - 8.7 6.7 11.1 25 5.2 4.9 2.5 2 1 1 3 3 3 0 Poxvirus entry protein complex L1 and I2 MIG-14_Wnt-bd PF06664.12 ORX70514.1 - 0.039 13.2 0.1 0.053 12.7 0.1 1.2 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion DUF1461 PF07314.11 ORX70514.1 - 0.054 13.4 0.3 0.072 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Syndecan PF01034.20 ORX70514.1 - 2.8 7.9 4.3 12 5.9 0.2 2.2 2 0 0 2 2 2 0 Syndecan domain DRMBL PF07522.14 ORX70515.1 - 8e-17 61.4 0.1 3e-16 59.6 0.1 1.9 1 1 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ORX70515.1 - 0.0017 17.9 1.3 0.0049 16.4 0.4 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX70515.1 - 0.024 14.6 1.6 0.024 14.6 1.6 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Ribonuclease_3 PF00636.26 ORX70518.1 - 5.2e-39 133.1 0.0 4.4e-19 69.1 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 ORX70518.1 - 3.1e-22 78.5 0.0 7.1e-22 77.4 0.0 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 ORX70518.1 - 1.2e-21 77.2 0.8 3.1e-07 30.6 0.0 4.7 4 0 0 4 4 4 3 Ribonuclease-III-like Methyltransf_31 PF13847.6 ORX70518.1 - 3e-16 59.6 0.0 7.2e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Helicase_C PF00271.31 ORX70518.1 - 3.2e-14 53.2 0.1 1.2e-13 51.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Methyltransf_25 PF13649.6 ORX70518.1 - 2.9e-10 40.7 0.0 1.3e-09 38.6 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain ResIII PF04851.15 ORX70518.1 - 1.1e-06 28.8 0.0 2.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Methyltransf_11 PF08241.12 ORX70518.1 - 1.5e-06 28.7 0.0 8.6e-06 26.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DEAD PF00270.29 ORX70518.1 - 4.3e-05 23.3 0.0 0.00015 21.6 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase PCMT PF01135.19 ORX70518.1 - 0.00019 21.3 0.0 0.00036 20.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ORX70518.1 - 0.04 13.8 0.0 0.48 10.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 ORX70518.1 - 0.071 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX70519.1 - 9.1e-20 71.0 0.0 1.4e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70519.1 - 8.6e-12 45.6 0.0 1.4e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70519.1 - 6.5e-10 39.5 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX70519.1 - 1.9e-09 37.6 0.0 2.9e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70519.1 - 2.9e-08 34.4 0.0 5.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX70519.1 - 5.9e-05 22.9 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ORX70519.1 - 7.1e-05 22.3 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 ORX70519.1 - 0.0013 18.2 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX70519.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 ORX70519.1 - 0.21 10.9 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ldh_1_N PF00056.23 ORX70520.1 - 1.1e-41 142.2 0.1 1.5e-41 141.8 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ORX70520.1 - 1.6e-41 142.0 0.0 2.6e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 ORX70520.1 - 0.00011 21.3 0.0 0.00015 20.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 ORX70520.1 - 0.032 14.7 0.1 0.068 13.6 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.16 ORX70520.1 - 0.033 13.7 0.1 0.54 9.8 0.1 2.1 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase DUF3945 PF13101.6 ORX70520.1 - 0.092 12.5 0.0 6.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) DapB_N PF01113.20 ORX70520.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus MCM_bind PF09739.9 ORX70521.1 - 3.1e-25 88.7 0.3 3.5e-25 88.5 0.3 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor MCM_lid PF17855.1 ORX70521.1 - 4.6e-06 26.9 0.8 6.6e-06 26.5 0.6 1.4 1 1 0 1 1 1 1 MCM AAA-lid domain Cas6 PF09559.10 ORX70521.1 - 0.12 12.4 0.2 0.17 11.9 0.2 1.2 1 1 0 1 1 1 0 Cas6 Crispr MCM_bind PF09739.9 ORX70522.1 - 3.4e-07 29.1 0.2 1.3e-06 27.2 0.1 1.7 2 0 0 2 2 2 1 Mini-chromosome maintenance replisome factor Fve PF09259.11 ORX70522.1 - 0.2 11.8 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal immunomodulatory protein Fve Sec63 PF02889.16 ORX70523.1 - 9.3e-18 64.3 0.1 2.5e-17 62.9 0.1 1.6 1 1 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.31 ORX70523.1 - 7.9e-11 41.9 0.1 2e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain RNase_H2-Ydr279 PF09468.10 ORX70523.1 - 0.094 12.9 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Herpes_heli_pri PF05774.11 ORX70523.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component N_BRCA1_IG PF16158.5 ORX70523.1 - 0.18 12.6 0.6 2.3 9.0 0.1 2.8 2 1 0 2 2 2 0 Ig-like domain from next to BRCA1 gene FAM72 PF14976.6 ORX70524.1 - 2.1e-51 173.9 5.9 2.6e-51 173.6 5.9 1.0 1 0 0 1 1 1 1 FAM72 protein Yippee-Mis18 PF03226.14 ORX70524.1 - 0.0082 16.3 0.5 0.0082 16.3 0.5 2.1 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Gmx_para_CXXCG PF09535.10 ORX70524.1 - 0.12 11.6 0.4 0.18 11.1 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) CMAS PF02353.20 ORX70525.1 - 3.7e-79 265.9 0.0 1.7e-75 253.8 0.0 2.1 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ORX70525.1 - 3.8e-13 50.0 0.0 1.1e-12 48.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70525.1 - 1.3e-11 45.0 0.0 3e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70525.1 - 9.6e-09 35.9 0.0 2.9e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70525.1 - 1e-08 35.1 0.0 2.2e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX70525.1 - 1.8e-08 34.4 0.0 3.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 ORX70525.1 - 0.0009 18.8 0.0 0.0024 17.4 0.0 1.7 1 0 0 1 1 1 1 Histone methylation protein DOT1 FtsJ PF01728.19 ORX70525.1 - 0.0023 18.1 0.0 0.0037 17.4 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 ORX70525.1 - 0.0032 17.1 0.1 0.0088 15.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX70525.1 - 0.0067 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX70525.1 - 0.022 14.7 0.1 0.052 13.5 0.0 1.6 2 0 0 2 2 1 0 Methyltransferase domain PrmA PF06325.13 ORX70525.1 - 0.029 13.8 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 ORX70525.1 - 0.042 13.6 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ORX70526.1 - 1.1e-69 234.8 0.1 8.9e-66 222.0 0.0 2.8 2 1 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ORX70526.1 - 2.1e-11 44.4 0.0 5e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70526.1 - 1.5e-09 38.4 0.0 3.1e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70526.1 - 4.8e-07 30.4 0.0 1.2e-06 29.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70526.1 - 5.7e-07 29.4 0.0 1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX70526.1 - 4.1e-05 23.5 0.0 8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 ORX70526.1 - 0.00085 18.9 0.0 0.0027 17.3 0.0 1.8 2 0 0 2 2 2 1 Histone methylation protein DOT1 FtsJ PF01728.19 ORX70526.1 - 0.0029 17.7 0.0 0.0065 16.6 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 ORX70526.1 - 0.0052 16.4 0.0 0.0097 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX70526.1 - 0.0083 16.1 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX70526.1 - 0.026 14.4 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ORX70526.1 - 0.031 13.7 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 ORX70526.1 - 0.047 13.4 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 ORX70526.1 - 0.2 10.7 0.0 0.95 8.5 0.0 2.0 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Ecm29 PF13001.7 ORX70527.1 - 1.4e-41 142.8 0.0 6.4e-39 134.0 0.0 3.5 2 1 0 2 2 2 1 Proteasome stabiliser HEAT_EZ PF13513.6 ORX70527.1 - 8.6e-08 32.5 22.4 1.3 9.6 0.1 8.9 9 0 0 9 9 9 4 HEAT-like repeat HEAT PF02985.22 ORX70527.1 - 0.061 13.6 16.7 22 5.6 0.0 10.7 12 0 0 12 12 12 0 HEAT repeat Mit_KHE1 PF10173.9 ORX70528.1 - 2.5e-42 145.1 1.0 3.5e-42 144.6 1.0 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Ost4 PF10215.9 ORX70528.1 - 0.044 13.6 0.1 0.084 12.7 0.1 1.5 1 0 0 1 1 1 0 Oligosaccaryltransferase zf-C2H2 PF00096.26 ORX70529.1 - 4.9e-11 42.4 6.5 1e-05 25.7 0.2 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX70529.1 - 3.2e-06 27.5 4.5 0.03 15.1 0.1 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX70529.1 - 0.00015 22.0 1.0 0.00015 22.0 1.0 3.1 3 0 0 3 3 3 1 Zinc-finger double domain FOXP-CC PF16159.5 ORX70529.1 - 0.005 17.4 0.6 0.29 11.8 0.1 2.0 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 ORX70529.1 - 0.023 15.0 0.5 0.045 14.0 0.5 1.5 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX70529.1 - 0.028 14.2 0.4 0.064 13.0 0.4 1.6 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX70529.1 - 0.035 14.1 5.2 0.38 10.8 0.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 ORX70529.1 - 0.12 12.9 2.2 11 6.6 0.4 2.5 2 1 0 2 2 2 0 Zinc-finger of C2H2 type BAH PF01426.18 ORX70530.1 - 4.9e-18 65.2 0.7 9.8e-18 64.2 0.0 1.8 2 0 0 2 2 2 1 BAH domain PHD PF00628.29 ORX70530.1 - 3e-09 36.6 32.6 3.6e-06 26.8 8.0 4.9 5 0 0 5 5 5 2 PHD-finger zf-HC5HC2H_2 PF13832.6 ORX70530.1 - 4.8e-08 33.2 18.9 7.6e-06 26.1 0.0 4.2 4 0 0 4 4 4 2 PHD-zinc-finger like domain ELM2 PF01448.24 ORX70530.1 - 0.00044 20.9 0.1 0.0018 19.0 0.1 2.1 1 1 0 1 1 1 1 ELM2 domain PHD_2 PF13831.6 ORX70530.1 - 0.0013 18.2 5.9 0.0013 18.2 5.9 4.1 4 0 0 4 4 4 1 PHD-finger Zf_RING PF16744.5 ORX70530.1 - 0.0015 18.6 3.6 0.0015 18.6 3.6 3.3 2 1 0 2 2 2 1 KIAA1045 RING finger zf-HC5HC2H PF13771.6 ORX70530.1 - 0.013 15.7 29.7 0.027 14.7 0.0 4.8 5 1 1 6 6 6 0 PHD-like zinc-binding domain Hormone_3 PF00159.18 ORX70530.1 - 0.015 15.4 0.0 0.082 13.0 0.0 2.3 2 0 0 2 2 2 0 Pancreatic hormone peptide C1_1 PF00130.22 ORX70530.1 - 0.015 15.2 35.8 0.029 14.2 4.7 5.1 4 1 1 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ORX70530.1 - 0.055 13.8 22.6 0.66 10.3 0.2 4.9 5 0 0 5 5 4 0 C1 domain Myb_DNA-bind_7 PF15963.5 ORX70530.1 - 0.2 11.6 0.0 0.43 10.5 0.0 1.5 1 0 0 1 1 1 0 Myb DNA-binding like Prefoldin PF02996.17 ORX70531.1 - 1.1e-13 51.2 0.1 1.1e-13 51.2 0.1 2.3 3 0 0 3 3 3 1 Prefoldin subunit Prefoldin_3 PF13758.6 ORX70531.1 - 8.7e-08 32.1 0.0 8.7e-08 32.1 0.0 2.6 3 0 0 3 3 3 1 Prefoldin subunit BUD22 PF09073.10 ORX70531.1 - 0.13 11.6 27.7 0.12 11.7 23.7 2.3 2 0 0 2 2 2 0 BUD22 HsdM_N PF12161.8 ORX70531.1 - 5.3 7.7 15.9 0.085 13.5 6.1 2.4 2 0 0 2 2 2 0 HsdM N-terminal domain ChapFlgA PF13144.6 ORX70532.1 - 0.007 16.4 0.0 0.0093 16.0 0.0 1.1 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation POR_N PF01855.19 ORX70532.1 - 0.014 15.2 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Roughex PF06020.11 ORX70533.1 - 9.2 5.2 6.6 15 4.5 6.6 1.3 1 0 0 1 1 1 0 Drosophila roughex protein COX5A PF02284.16 ORX70535.1 - 5.2e-31 106.7 2.2 1.3e-30 105.4 2.2 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase subunit Va HigB-like_toxin PF05015.13 ORX70535.1 - 0.013 15.9 0.1 0.018 15.4 0.1 1.2 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB PaaX_C PF08223.11 ORX70535.1 - 0.058 13.7 0.5 0.34 11.2 0.1 2.0 2 0 0 2 2 2 0 PaaX-like protein C-terminal domain MAPKK1_Int PF08923.10 ORX70536.1 - 1.8e-13 50.3 0.1 2.2e-13 50.0 0.1 1.1 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting DnaJ PF00226.31 ORX70537.1 - 2.4e-24 85.2 0.1 2.6e-24 85.1 0.1 1.0 1 0 0 1 1 1 1 DnaJ domain NmrA PF05368.13 ORX70538.1 - 4.3e-35 121.4 0.4 5.5e-35 121.0 0.4 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX70538.1 - 4.9e-18 65.7 0.0 9e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ORX70538.1 - 1.4e-09 38.2 0.3 1.2e-08 35.3 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ORX70538.1 - 0.00024 20.6 0.1 0.016 14.7 0.1 2.3 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ORX70538.1 - 0.024 15.1 0.1 0.062 13.7 0.1 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain zf-CCCH_3 PF15663.5 ORX70539.1 - 0.08 13.2 3.0 4.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger containing family NmrA PF05368.13 ORX70540.1 - 1.9e-39 135.6 0.3 2.3e-39 135.3 0.3 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX70540.1 - 2.5e-17 63.4 0.0 3.7e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ORX70540.1 - 7.2e-09 36.0 0.0 1.1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ORX70540.1 - 7.1e-06 25.6 0.1 0.0039 16.7 0.1 2.7 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family KDGP_aldolase PF07071.11 ORX70540.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 KDGP aldolase F420_oxidored PF03807.17 ORX70540.1 - 0.03 14.9 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 ORX70540.1 - 0.089 13.2 0.3 0.17 12.3 0.1 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Adaptin_N PF01602.20 ORX70541.1 - 9e-107 357.8 5.1 1.4e-106 357.2 5.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ORX70541.1 - 2.4e-24 85.7 0.0 5.4e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ORX70541.1 - 6.7e-10 39.3 0.0 1.3e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ORX70541.1 - 0.017 15.2 1.5 4 7.5 0.5 3.1 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ORX70541.1 - 0.19 11.9 0.8 1.1 9.5 0.3 2.4 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 ORX70541.1 - 0.25 11.7 2.7 1.7 9.1 0.1 3.8 5 0 0 5 5 5 0 HEAT repeat BK_channel_a PF03493.18 ORX70542.1 - 2.8e-24 85.2 0.1 9.7e-24 83.4 0.1 1.9 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Phage_TAC_6 PF09550.10 ORX70542.1 - 0.023 15.1 0.3 0.11 12.9 0.1 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC Ion_trans_2 PF07885.16 ORX70542.1 - 0.11 12.5 2.9 0.34 10.9 2.9 1.8 1 0 0 1 1 1 0 Ion channel zf-C2H2 PF00096.26 ORX70543.1 - 4.1e-12 45.9 25.4 0.0012 19.2 11.5 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ORX70543.1 - 2e-09 37.2 10.0 0.0011 18.9 0.1 3.3 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX70543.1 - 1e-08 35.2 18.1 0.0058 17.4 6.8 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX70543.1 - 2.2e-07 31.0 6.0 0.13 12.6 1.0 3.1 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 ORX70543.1 - 6.1e-05 23.3 13.4 0.012 16.0 2.0 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-CHY PF05495.12 ORX70543.1 - 0.00052 20.5 1.9 0.00072 20.0 1.9 1.4 1 0 0 1 1 1 1 CHY zinc finger zf-met PF12874.7 ORX70543.1 - 0.00068 19.9 6.2 1.9 9.0 1.2 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 ORX70543.1 - 0.0031 17.4 11.6 0.014 15.3 0.3 3.1 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf_ZIC PF18366.1 ORX70543.1 - 0.023 14.8 8.2 3.8 7.7 2.3 3.1 1 1 2 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_3rep PF18868.1 ORX70543.1 - 0.027 15.1 5.8 0.26 12.0 1.0 2.1 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-AN1 PF01428.16 ORX70543.1 - 0.028 14.6 15.0 0.77 10.0 8.4 2.5 2 1 0 2 2 2 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 ORX70543.1 - 0.028 14.5 4.2 0.17 12.0 4.3 2.3 1 1 0 1 1 1 0 Zinc ribbon domain C1_2 PF03107.16 ORX70543.1 - 0.033 14.5 8.7 0.75 10.2 1.6 2.2 1 1 1 2 2 2 0 C1 domain zf-C2H2_11 PF16622.5 ORX70543.1 - 0.043 13.6 0.1 0.043 13.6 0.1 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-FCS PF06467.14 ORX70543.1 - 0.044 13.7 5.5 0.086 12.8 0.6 2.2 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zinc-ribbons_6 PF07191.12 ORX70543.1 - 0.046 13.7 1.5 6.8 6.8 0.2 2.1 1 1 1 2 2 2 0 zinc-ribbons C1_4 PF07975.12 ORX70543.1 - 0.16 12.2 7.7 0.093 13.0 2.0 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain DUF2256 PF10013.9 ORX70543.1 - 1 9.5 6.0 8.7 6.6 0.2 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_Tnp_IS1595 PF12760.7 ORX70543.1 - 2.4 8.2 9.2 5.5 7.0 9.2 1.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain SP_C-Propep PF08999.10 ORX70544.1 - 0.14 12.0 1.0 2.4 8.0 0.1 2.2 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide UCH PF00443.29 ORX70546.1 - 0.046 13.2 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Kinesin PF00225.23 ORX70547.1 - 3.3e-71 239.9 2.7 1.1e-39 136.3 0.6 3.4 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ORX70547.1 - 4e-13 49.5 0.4 9.3e-10 38.6 0.0 2.8 1 1 1 2 2 2 2 Microtubule binding JIP_LZII PF16471.5 ORX70547.1 - 0.012 15.7 7.6 0.42 10.8 0.3 4.0 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II DUF4854 PF16146.5 ORX70547.1 - 0.061 13.7 2.3 0.81 10.1 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) BST2 PF16716.5 ORX70547.1 - 0.45 11.1 13.3 1.6 9.4 1.2 3.6 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 DivIC PF04977.15 ORX70547.1 - 1.5 8.6 11.3 1.6 8.5 0.6 4.1 3 1 0 4 4 4 0 Septum formation initiator GIT_CC PF16559.5 ORX70547.1 - 1.7 8.6 18.3 0.42 10.5 1.0 4.7 4 1 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor LPP PF04728.13 ORX70547.1 - 4.6 7.7 9.4 17 5.9 0.1 4.0 4 0 0 4 4 4 0 Lipoprotein leucine-zipper FAM76 PF16046.5 ORX70547.1 - 9.8 5.4 10.0 5.7 6.2 1.5 2.7 3 1 0 3 3 3 0 FAM76 protein ABC_tran PF00005.27 ORX70549.1 - 3.3e-40 137.8 0.0 6e-30 104.5 0.0 3.3 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX70549.1 - 3.6e-29 102.3 10.6 5.4e-26 91.8 9.4 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX70549.1 - 3.4e-09 36.5 3.8 0.00039 19.9 0.2 3.7 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX70549.1 - 1e-06 28.8 0.5 0.052 13.6 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX70549.1 - 6.8e-05 22.5 0.2 0.17 11.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 ORX70549.1 - 9.3e-05 22.5 1.6 0.002 18.2 0.1 2.5 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.17 ORX70549.1 - 0.0001 22.5 0.2 0.073 13.1 0.0 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 ORX70549.1 - 0.0002 21.8 0.5 0.85 10.0 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX70549.1 - 0.00022 21.2 0.1 0.41 10.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ORX70549.1 - 0.00096 19.0 3.2 0.72 9.6 0.0 3.2 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 ORX70549.1 - 0.0012 17.9 0.0 0.18 10.8 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DEAD PF00270.29 ORX70549.1 - 0.02 14.7 0.1 0.38 10.5 0.1 2.5 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_15 PF13175.6 ORX70549.1 - 0.025 14.3 0.1 1.5 8.5 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 ORX70549.1 - 0.026 13.4 0.1 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 ORX70549.1 - 0.029 14.7 1.1 7.2 6.9 0.1 3.1 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ORX70549.1 - 0.052 12.8 0.1 3.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ORX70549.1 - 0.058 13.1 0.3 22 4.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 ORX70549.1 - 0.064 13.0 0.0 5.1 6.8 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.6 ORX70549.1 - 0.071 13.6 0.0 7.3 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain FKBP_N_2 PF18023.1 ORX70549.1 - 0.074 13.2 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 BDBT FKBP like N-terminal AAA_7 PF12775.7 ORX70549.1 - 0.075 12.5 0.1 6.8 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 ORX70549.1 - 0.13 11.9 0.2 17 4.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 ORX70549.1 - 0.13 11.4 0.1 10 5.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 ORX70549.1 - 0.2 12.2 0.8 11 6.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX70549.1 - 0.53 10.0 2.3 25 4.5 1.5 2.8 2 1 0 2 2 2 0 AAA domain CEP209_CC5 PF16574.5 ORX70550.1 - 0.057 13.6 0.3 0.077 13.2 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 Ank_4 PF13637.6 ORX70551.1 - 1.9e-12 47.4 0.0 2.4e-07 31.1 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX70551.1 - 9.3e-09 35.8 0.0 1.7e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX70551.1 - 5.4e-06 26.6 0.0 0.00011 22.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX70551.1 - 9.7e-05 22.5 0.0 0.0057 17.1 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ORX70551.1 - 0.00022 21.5 0.0 0.44 11.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Peptidase_S9 PF00326.21 ORX70553.1 - 2.4e-35 121.9 0.0 5.6e-35 120.8 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 ORX70553.1 - 2e-27 96.1 0.6 2.4e-18 66.1 0.2 3.1 1 1 1 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Esterase PF00756.20 ORX70553.1 - 0.00019 21.2 0.5 0.0007 19.3 0.1 2.1 3 0 0 3 3 3 1 Putative esterase Hydrolase_4 PF12146.8 ORX70553.1 - 0.039 13.2 0.0 0.52 9.5 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 dCache_1 PF02743.18 ORX70553.1 - 0.056 13.2 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 Cache domain Peptidase_S15 PF02129.18 ORX70553.1 - 0.057 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Mon1 PF03164.14 ORX70554.1 - 8e-81 272.2 0.1 8.1e-79 265.6 0.1 3.3 1 1 0 1 1 1 1 Trafficking protein Mon1 DUF1011 PF06237.12 ORX70554.1 - 0.097 13.0 0.1 0.47 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) TetR_C_24 PF17932.1 ORX70554.1 - 0.12 12.6 0.4 0.54 10.5 0.3 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Acatn PF13000.7 ORX70555.1 - 1.1e-142 476.4 25.4 8.2e-73 245.8 12.2 3.6 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 CBM_14 PF01607.24 ORX70558.1 - 1 9.6 19.4 0.62 10.3 5.4 3.9 2 1 1 3 3 3 0 Chitin binding Peritrophin-A domain GLTSCR1 PF15249.6 ORX70559.1 - 8.9e-13 48.6 2.3 1.6e-12 47.7 0.1 2.4 3 0 0 3 3 3 1 Conserved region of unknown function on GLTSCR protein 4HBT_3 PF13622.6 ORX70560.1 - 1.7e-54 185.7 0.4 2.3e-54 185.3 0.4 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX70560.1 - 2.1e-30 105.3 0.0 3.5e-26 91.6 0.0 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase Lipase_GDSL PF00657.22 ORX70562.1 - 5.6e-08 33.0 0.0 9.9e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX70562.1 - 0.0031 17.9 0.1 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_2 PF13472.6 ORX70563.1 - 1.5e-05 25.5 0.3 3.2e-05 24.4 0.3 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX70563.1 - 3.1e-05 24.0 0.0 4.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL PF00657.22 ORX70564.1 - 3.7e-11 43.4 0.0 4.6e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX70564.1 - 6e-05 23.5 0.2 0.00019 21.9 0.2 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX70565.1 - 8e-06 26.0 0.0 1.1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX70565.1 - 0.0003 21.2 0.0 0.00039 20.9 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Ribosomal_L7Ae PF01248.26 ORX70567.1 - 1.1e-28 98.8 0.0 1.3e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 ORX70567.1 - 0.0013 18.5 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 ORX70567.1 - 0.0051 16.9 0.0 0.0062 16.6 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 FlxA PF14282.6 ORX70567.1 - 0.19 11.8 2.8 8.8 6.4 0.3 2.2 2 0 0 2 2 2 0 FlxA-like protein TPR_2 PF07719.17 ORX70568.1 - 5.5e-07 29.2 7.0 0.0016 18.4 0.8 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX70568.1 - 2e-06 27.4 5.5 0.00045 19.9 1.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX70568.1 - 0.00085 19.2 0.4 0.62 10.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX70568.1 - 0.0011 18.6 1.9 0.0052 16.4 0.2 2.4 2 0 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 ORX70568.1 - 0.012 15.8 2.3 0.14 12.5 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX70568.1 - 0.014 16.0 2.9 0.58 10.9 0.3 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX70568.1 - 0.03 14.6 1.8 15 6.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5355 PF17306.2 ORX70568.1 - 0.031 13.3 0.6 0.04 13.0 0.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5355) TPR_19 PF14559.6 ORX70568.1 - 0.048 14.2 0.3 5.5 7.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NDUFB10 PF10249.9 ORX70569.1 - 0.0026 18.3 0.1 0.0029 18.1 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 Fcf2 PF08698.11 ORX70570.1 - 3.4e-30 104.3 0.1 3.4e-30 104.3 0.1 2.0 2 1 1 3 3 3 1 Fcf2 pre-rRNA processing TruD PF01142.18 ORX70571.1 - 0.00055 18.9 0.0 0.0011 17.9 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) p450 PF00067.22 ORX70572.1 - 9.4e-60 202.6 0.0 1.2e-59 202.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mito_fiss_reg PF05308.11 ORX70573.1 - 0.068 13.2 0.7 0.094 12.8 0.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 ORX70573.1 - 0.079 12.4 2.1 0.1 12.1 2.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CFEM PF05730.11 ORX70573.1 - 0.28 11.3 8.1 0.45 10.6 8.1 1.3 1 0 0 1 1 1 0 CFEM domain Myb_Cef PF11831.8 ORX70574.1 - 8.7e-28 97.5 7.2 8.7e-28 97.5 7.2 5.1 4 1 1 5 5 5 2 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 ORX70574.1 - 1.5e-22 79.5 4.5 3.9e-11 42.9 1.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX70574.1 - 1.7e-21 76.2 5.7 8.3e-14 51.6 2.6 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain GILT PF03227.16 ORX70575.1 - 5.8e-15 55.4 2.2 1e-14 54.7 1.2 1.9 1 1 1 2 2 2 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Rotamase_3 PF13616.6 ORX70576.1 - 7.1e-19 68.5 0.8 2.9e-18 66.5 0.8 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 ORX70576.1 - 3.2e-17 63.3 1.0 7.4e-17 62.1 0.1 1.9 1 1 1 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ORX70576.1 - 2.1e-05 25.4 0.1 3.5e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Prefoldin_2 PF01920.20 ORX70577.1 - 1e-19 70.4 3.3 1.2e-19 70.2 3.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit MAP65_ASE1 PF03999.12 ORX70577.1 - 0.0037 16.1 1.1 0.0042 15.9 1.1 1.0 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) FliD_C PF07195.12 ORX70577.1 - 0.012 15.0 0.5 0.03 13.7 0.0 1.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus KfrA_N PF11740.8 ORX70577.1 - 0.035 14.8 3.2 0.044 14.5 2.6 1.6 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Prefoldin PF02996.17 ORX70577.1 - 0.038 13.9 2.1 0.038 13.9 2.1 1.9 1 1 1 2 2 2 0 Prefoldin subunit DUF4407 PF14362.6 ORX70577.1 - 0.066 12.5 0.3 0.083 12.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 ORX70577.1 - 0.076 13.0 1.9 0.17 11.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 ORX70577.1 - 0.47 11.1 3.2 0.74 10.5 0.2 2.0 1 1 1 2 2 2 0 Initiation control protein YabA ABC_tran_CTD PF16326.5 ORX70577.1 - 1.4 9.2 9.5 0.26 11.6 1.4 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain bZIP_1 PF00170.21 ORX70577.1 - 3.9 7.7 7.0 1.7 8.8 0.9 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF4140 PF13600.6 ORX70577.1 - 5 7.6 7.5 25 5.4 7.5 1.9 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 ORX70577.1 - 5.3 7.6 9.6 14 6.2 9.6 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region MtrG PF04210.13 ORX70577.1 - 6.4 6.7 5.4 19 5.2 0.3 2.9 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DER1 PF04511.15 ORX70578.1 - 2e-21 76.8 8.3 2.3e-20 73.3 6.7 2.0 1 1 1 2 2 2 2 Der1-like family Sedlin_N PF04628.13 ORX70579.1 - 6.3e-40 136.3 0.2 3.4e-39 134.0 0.2 1.8 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 ORX70579.1 - 5.1e-09 36.2 0.0 5.8e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Symplekin_C PF12295.8 ORX70580.1 - 6.4e-37 127.5 0.1 2e-36 125.8 0.1 1.9 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 ORX70580.1 - 4.9e-13 49.2 0.1 2.4e-11 43.7 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) Presenilin PF01080.17 ORX70580.1 - 9.4 4.9 7.8 16 4.1 7.8 1.3 1 0 0 1 1 1 0 Presenilin Lyase_1 PF00206.20 ORX70582.1 - 9.1e-100 334.1 0.9 1.2e-58 198.9 0.1 2.2 1 1 1 2 2 2 2 Lyase FumaraseC_C PF10415.9 ORX70582.1 - 8.1e-26 90.2 0.0 3.1e-25 88.3 0.0 2.1 2 0 0 2 2 2 1 Fumarase C C-terminus Cmc1 PF08583.10 ORX70583.1 - 8e-14 51.4 2.2 1.1e-13 51.0 2.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 ORX70583.1 - 0.00084 19.0 2.0 0.0011 18.6 2.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CDP-OH_P_transf PF01066.21 ORX70584.1 - 3e-05 24.7 1.3 3e-05 24.7 1.3 2.1 2 1 1 3 3 3 1 CDP-alcohol phosphatidyltransferase Methyltransf_3 PF01596.17 ORX70585.1 - 7.6e-23 80.8 1.1 1.2e-22 80.1 1.1 1.3 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX70585.1 - 4.9e-12 46.8 0.0 7.4e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX70585.1 - 0.0033 17.2 0.0 0.0047 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ORX70585.1 - 0.0055 17.4 0.0 0.029 15.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain TraB PF01963.17 ORX70585.1 - 0.052 13.4 0.0 0.067 13.1 0.0 1.2 1 0 0 1 1 1 0 TraB family UPF0020 PF01170.18 ORX70585.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_30 PF05430.11 ORX70585.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase MFS_1 PF07690.16 ORX70586.1 - 4.4e-11 42.3 37.5 9.4e-11 41.2 11.0 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 ORX70586.1 - 1.9e-06 27.6 9.2 1.9e-06 27.6 9.2 2.2 2 1 0 2 2 2 1 Nodulin-like PI3_PI4_kinase PF00454.27 ORX70587.1 - 2e-41 142.5 0.4 4.1e-40 138.2 0.4 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ORX70587.1 - 1.2e-11 44.2 0.0 2.1e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 ORX70588.1 - 2e-17 63.4 0.4 2.6e-14 53.2 0.0 2.3 2 0 0 2 2 2 2 FAT domain DUF3618 PF12277.8 ORX70588.1 - 0.013 15.7 0.0 0.034 14.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3618) Haem_oxygenas_2 PF14518.6 ORX70588.1 - 0.17 11.7 1.0 1 9.1 1.0 2.2 2 1 0 2 2 2 0 Iron-containing redox enzyme PCI PF01399.27 ORX70590.1 - 1.4e-07 32.0 0.0 3e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 PCI domain NIF PF03031.18 ORX70591.1 - 6.8e-52 175.4 0.1 8.3e-52 175.1 0.1 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MBOAT PF03062.19 ORX70592.1 - 5.3e-43 147.7 21.0 1e-42 146.8 21.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SQHop_cyclase_N PF13249.6 ORX70593.1 - 3.2e-35 121.6 1.7 1e-25 90.4 0.6 5.2 2 2 4 6 6 6 5 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 ORX70593.1 - 1.4e-24 86.8 5.2 4.5e-15 55.6 1.3 3.9 2 1 1 3 3 3 3 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 ORX70593.1 - 1.5e-18 66.2 17.8 9.6e-09 34.8 0.6 6.9 7 0 0 7 7 7 3 Prenyltransferase and squalene oxidase repeat Mago-bind PF09282.10 ORX70593.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Mago binding SOR_SNZ PF01680.17 ORX70594.1 - 2.3e-112 373.8 5.2 2.3e-112 373.8 5.2 1.6 2 0 0 2 2 2 1 SOR/SNZ family ThiG PF05690.14 ORX70594.1 - 1.3e-05 24.7 4.2 0.0094 15.3 0.1 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ORX70594.1 - 0.00044 19.5 2.1 0.48 9.5 0.1 2.6 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ORX70594.1 - 0.027 14.0 0.9 0.7 9.3 0.1 2.3 2 0 0 2 2 2 0 Histidine biosynthesis protein CFEM PF05730.11 ORX70596.1 - 0.0055 16.8 14.4 0.2 11.8 2.1 2.3 1 1 1 2 2 2 2 CFEM domain GREB1 PF15782.5 ORX70596.1 - 3.9 4.5 8.7 4.6 4.2 8.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NPR3 PF03666.13 ORX70596.1 - 5.5 5.7 11.3 7.6 5.2 11.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zmiz1_N PF18028.1 ORX70597.1 - 5.6e-07 29.8 0.1 1.1e-06 28.9 0.1 1.4 1 0 0 1 1 1 1 Zmiz1 N-terminal tetratricopeptide repeat domain MFS_1 PF07690.16 ORX70598.1 - 9e-24 84.0 43.3 4.2e-16 58.8 15.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GDA1_CD39 PF01150.17 ORX70599.1 - 4.9e-73 246.2 0.0 3.9e-72 243.2 0.0 2.1 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Myc_target_1 PF15179.6 ORX70599.1 - 0.077 12.9 0.1 1.5 8.7 0.1 2.2 2 0 0 2 2 2 0 Myc target protein 1 SLAC1 PF03595.17 ORX70600.1 - 3.9e-66 223.5 39.3 4.7e-66 223.3 39.3 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel PMP1_2 PF08114.11 ORX70600.1 - 0.38 10.5 4.5 0.76 9.6 0.7 2.9 2 0 0 2 2 2 0 ATPase proteolipid family Hum_adeno_E3A PF05393.11 ORX70600.1 - 3.9 7.5 7.3 0.57 10.2 0.9 2.7 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein Ubie_methyltran PF01209.18 ORX70601.1 - 3.3e-28 98.6 0.0 3.6e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX70601.1 - 1.1e-19 70.9 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70601.1 - 2.6e-18 66.5 0.0 4.3e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70601.1 - 3.9e-16 59.2 0.0 4.6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX70601.1 - 1.2e-11 44.8 0.0 1.6e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70601.1 - 2.9e-09 37.5 0.0 4.2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX70601.1 - 0.00026 20.6 0.0 0.00057 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ORX70601.1 - 0.00085 19.2 0.0 0.0091 15.9 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_24 PF13578.6 ORX70601.1 - 0.11 13.5 0.0 0.16 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Gtr1_RagA PF04670.12 ORX70602.1 - 1.6e-84 282.9 0.7 2e-84 282.6 0.7 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX70602.1 - 1e-06 28.8 0.0 2.4e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 ORX70602.1 - 1.1e-06 28.9 0.2 3.9e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX70602.1 - 4.7e-06 26.2 0.2 7.4e-06 25.5 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ORX70602.1 - 0.00017 21.2 1.1 0.00032 20.3 0.2 1.9 2 0 0 2 2 2 1 Ras family DUF2856 PF11043.8 ORX70602.1 - 0.037 14.2 0.1 0.17 12.0 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2856) G-alpha PF00503.20 ORX70602.1 - 0.063 12.4 0.3 0.18 10.9 0.1 1.7 1 1 0 2 2 2 0 G-protein alpha subunit CASP_C PF08172.12 ORX70603.1 - 2.9e-56 190.6 7.9 2.9e-56 190.6 7.9 6.4 2 2 1 3 3 1 1 CASP C terminal CdvA PF18822.1 ORX70603.1 - 0.015 15.2 2.4 0.015 15.2 2.4 5.3 5 1 2 7 7 7 0 CdvA-like coiled-coil domain Golgin_A5 PF09787.9 ORX70603.1 - 0.015 14.8 2.1 0.015 14.8 2.1 5.9 3 2 3 6 6 5 0 Golgin subfamily A member 5 DUF2205 PF10224.9 ORX70603.1 - 0.02 14.9 0.4 0.02 14.9 0.4 5.8 4 1 2 6 6 6 0 Short coiled-coil protein Mto2_bdg PF12808.7 ORX70603.1 - 0.042 14.1 0.6 0.042 14.1 0.6 6.2 6 3 0 6 6 5 0 Micro-tubular organiser Mto1 C-term Mto2-binding region FlaC_arch PF05377.11 ORX70603.1 - 0.4 11.1 17.3 12 6.3 0.3 5.9 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) HALZ PF02183.18 ORX70603.1 - 0.81 10.0 0.0 0.81 10.0 0.0 6.5 6 2 1 7 7 7 0 Homeobox associated leucine zipper Rootletin PF15035.6 ORX70603.1 - 1.1 9.2 61.9 0.31 11.0 20.1 4.9 2 2 2 4 4 4 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 ORX70603.1 - 3.6 6.9 57.8 1.3 8.3 25.7 4.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF3763 PF12592.8 ORX70603.1 - 5.7 7.1 12.0 1.5 8.9 0.7 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3763) Spc42p PF11544.8 ORX70603.1 - 5.9 7.0 15.7 2.8 8.0 0.7 5.2 4 2 0 5 5 5 0 Spindle pole body component Spc42p Hist_deacetyl PF00850.19 ORX70606.1 - 3.1e-83 279.8 0.0 4e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glyco_hydro_16 PF00722.21 ORX70609.1 - 4e-37 127.4 3.4 4e-37 127.4 3.4 1.5 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 EccE PF11203.8 ORX70610.1 - 0.017 15.4 0.6 1.8 9.0 0.0 2.2 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE Pkinase_fungal PF17667.1 ORX70612.1 - 2.6e-35 122.0 0.0 1.6e-26 93.1 0.0 2.9 3 0 0 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX70612.1 - 0.003 17.0 0.0 0.0052 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ORX70612.1 - 0.042 13.8 1.2 0.08 12.9 0.2 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family NIF3 PF01784.18 ORX70614.1 - 5.8e-64 216.0 0.0 7.1e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) TUG-UBL1 PF11470.8 ORX70616.1 - 2.7e-19 69.2 0.0 8.8e-19 67.5 0.0 2.0 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 ORX70616.1 - 0.00014 22.0 0.1 0.00053 20.1 0.1 1.9 2 0 0 2 2 2 1 UBX domain DUF45 PF01863.17 ORX70616.1 - 0.11 12.5 0.1 2.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF45 MFS_1 PF07690.16 ORX70617.1 - 1.5e-07 30.7 9.9 1.5e-06 27.4 3.2 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70617.1 - 0.0065 15.4 1.3 0.015 14.2 0.1 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX70618.1 - 9.9e-29 100.3 18.3 3.6e-24 85.3 6.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX70618.1 - 4.4e-11 42.3 12.1 7.4e-11 41.6 12.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 ORX70618.1 - 0.00019 20.4 1.7 0.00019 20.4 1.7 2.4 2 0 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 ORX70618.1 - 0.00034 19.2 1.1 0.00071 18.1 1.1 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ECF-ribofla_trS PF07155.12 ORX70618.1 - 2.8 7.9 11.1 0.04 13.9 1.0 3.0 3 1 2 5 5 5 0 ECF-type riboflavin transporter, S component CAP_GLY PF01302.25 ORX70619.1 - 4.3e-17 61.9 2.6 5e-17 61.7 1.4 1.7 2 0 0 2 2 2 1 CAP-Gly domain LRR_4 PF12799.7 ORX70619.1 - 1.6e-13 50.5 8.3 7.6e-06 26.2 1.4 5.1 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX70619.1 - 2.2e-10 40.3 0.0 3.7e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 ORX70619.1 - 9.8e-08 31.7 9.3 0.00019 21.2 2.4 3.7 2 1 1 3 3 3 3 Leucine rich repeat Ubiquitin_2 PF14560.6 ORX70619.1 - 0.055 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain LRR_1 PF00560.33 ORX70619.1 - 0.18 12.4 5.2 2.7 8.9 1.0 4.4 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 ORX70619.1 - 1 9.6 16.2 3.9 7.8 0.9 5.6 6 0 0 6 6 6 0 Leucine Rich repeat DUF2407 PF10302.9 ORX70621.1 - 0.078 13.5 0.0 0.13 12.9 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Tom5 PF10642.9 ORX70623.1 - 5e-10 39.3 0.3 5.4e-10 39.1 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase ENOD93 PF03386.14 ORX70623.1 - 0.16 11.8 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein UBA PF00627.31 ORX70624.1 - 1.4e-29 101.6 2.8 4.1e-14 52.1 0.2 2.8 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 ORX70624.1 - 2.4e-20 72.0 17.4 4.6e-20 71.1 17.4 1.5 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 ORX70624.1 - 1.8e-19 69.2 0.9 2.8e-19 68.6 0.9 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX70624.1 - 1.6e-08 34.3 2.2 3.3e-08 33.2 2.2 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ORX70624.1 - 0.0019 18.3 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX70624.1 - 0.035 14.5 0.2 0.066 13.7 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain DUF1421 PF07223.11 ORX70624.1 - 0.059 13.2 0.0 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 UBA-like domain (DUF1421) WIYLD PF10440.9 ORX70624.1 - 0.1 12.4 0.0 13 5.6 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain MCM_N PF14551.6 ORX70624.1 - 0.11 13.1 0.7 0.47 11.1 0.1 2.2 2 0 0 2 2 2 0 MCM N-terminal domain DUF2407 PF10302.9 ORX70624.1 - 0.16 12.6 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Pkinase PF00069.25 ORX70626.1 - 6e-58 196.3 0.0 7e-58 196.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70626.1 - 4.3e-36 124.5 0.0 5.5e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX70626.1 - 6.8e-06 25.6 0.0 1.2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX70626.1 - 0.00022 20.1 0.0 0.00026 19.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX70626.1 - 0.0016 17.5 0.1 0.0032 16.5 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ORX70626.1 - 0.014 14.5 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Smg8_Smg9 PF10220.9 ORX70628.1 - 0.89 7.8 6.1 1.5 7.1 6.1 1.2 1 0 0 1 1 1 0 Smg8_Smg9 ArfGap PF01412.18 ORX70630.1 - 1.6e-32 112.0 0.0 3.7e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ORX70630.1 - 2.7e-07 31.0 0.1 6e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 PH domain Ank PF00023.30 ORX70630.1 - 6e-05 23.3 0.1 0.00028 21.2 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 ORX70630.1 - 8.3e-05 22.7 0.1 0.00034 20.8 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeat BAR_3 PF16746.5 ORX70630.1 - 0.00032 20.5 0.3 0.0014 18.4 0.3 1.9 1 1 0 1 1 1 1 BAR domain of APPL family Ank_4 PF13637.6 ORX70630.1 - 0.0011 19.5 0.1 0.0036 17.8 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX70630.1 - 0.0031 18.0 0.0 0.018 15.6 0.0 2.2 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX70630.1 - 0.0045 17.3 0.0 0.014 15.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PH_9 PF15410.6 ORX70630.1 - 0.0067 16.8 0.1 0.016 15.5 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Cullin PF00888.22 ORX70631.1 - 4e-161 537.7 0.0 5.4e-161 537.3 0.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX70631.1 - 7.2e-25 86.8 2.8 7.2e-25 86.8 2.8 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain CHDCT2 PF08074.11 ORX70631.1 - 0.069 13.3 0.0 0.069 13.3 0.0 2.3 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain Kelch_5 PF13854.6 ORX70634.1 - 3.8e-15 55.5 0.1 3e-06 27.1 0.1 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ORX70634.1 - 7.6e-14 51.1 0.3 7.3e-05 22.6 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ORX70634.1 - 6.6e-13 48.4 5.1 0.00093 19.2 0.2 5.4 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX70634.1 - 2.9e-12 46.4 0.4 0.0034 17.6 0.1 5.0 4 1 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ORX70634.1 - 3.1e-11 43.3 4.7 1.7e-06 28.2 0.4 5.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX70634.1 - 0.00021 20.8 7.4 0.096 12.3 0.0 5.1 7 0 0 7 7 7 2 Kelch motif Myc_target_1 PF15179.6 ORX70634.1 - 0.072 13.0 2.8 0.13 12.1 2.8 1.4 1 0 0 1 1 1 0 Myc target protein 1 ACP_syn_III PF08545.10 ORX70634.1 - 0.12 12.3 0.1 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DFRP_C PF16543.5 ORX70635.1 - 7.1e-27 93.7 2.9 7.1e-27 93.7 2.9 4.0 3 2 2 5 5 5 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 ORX70635.1 - 4.3e-07 29.7 1.4 4.3e-07 29.7 1.4 2.6 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ORX70635.1 - 1.5e-06 27.8 10.1 3.8e-06 26.5 2.1 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX70635.1 - 1.4e-05 25.0 6.8 1.4e-05 25.0 6.8 3.1 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 ORX70635.1 - 0.0015 19.2 4.7 0.0015 19.2 4.7 4.2 2 2 1 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 ORX70635.1 - 0.0061 17.0 9.0 0.025 15.0 2.8 2.8 2 1 0 2 2 2 1 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ORX70635.1 - 0.078 13.2 5.2 0.14 12.4 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger containing family Lipoprotein_2 PF00921.17 ORX70635.1 - 3 7.3 17.7 0.27 10.8 7.3 2.4 2 0 0 2 2 2 0 Borrelia lipoprotein UPF0240 PF06784.11 ORX70635.1 - 9.9 6.2 14.0 1.2 9.2 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) F-box-like PF12937.7 ORX70637.1 - 0.0083 16.0 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 ORX70640.1 - 0.028 14.3 0.0 0.075 12.9 0.0 1.7 1 0 0 1 1 1 0 F-box-like Sugar_tr PF00083.24 ORX70641.1 - 3.2e-97 326.2 21.1 3.7e-97 326.0 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX70641.1 - 1.6e-30 106.2 63.1 5.5e-29 101.2 28.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX70641.1 - 0.00072 18.1 2.0 0.00072 18.1 2.0 2.1 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4006 PF13179.6 ORX70641.1 - 0.21 11.5 1.1 24 4.9 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Pkinase PF00069.25 ORX70642.1 - 3.8e-37 128.1 0.0 5.3e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70642.1 - 1.4e-20 73.7 0.0 1.7e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX70642.1 - 0.053 12.9 0.0 0.071 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sds3 PF08598.11 ORX70644.1 - 1.7e-06 28.2 0.4 1.7e-06 28.2 0.4 2.5 2 1 0 2 2 2 1 Sds3-like DUF4575 PF15143.6 ORX70644.1 - 0.035 14.3 0.1 0.11 12.7 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4575) DUF2222 PF09984.9 ORX70644.1 - 0.28 11.1 5.7 0.56 10.1 2.3 2.8 2 0 0 2 2 2 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) RRM_1 PF00076.22 ORX70645.1 - 8.3e-42 140.9 0.1 4.1e-21 74.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX70645.1 - 1.4e-09 37.7 0.0 3.9e-05 23.4 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif DUF4129 PF13559.6 ORX70645.1 - 0.00013 22.2 0.7 0.00031 21.0 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4129) RRM_7 PF16367.5 ORX70645.1 - 0.0059 16.7 0.0 0.46 10.6 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RRM_3 PF08777.11 ORX70645.1 - 0.011 15.7 0.0 0.49 10.5 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM PF05172.13 ORX70645.1 - 0.02 14.8 0.0 0.66 10.0 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif LCAT PF02450.15 ORX70646.1 - 9.6e-68 229.1 0.0 1.2e-67 228.8 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Peptidase_C48 PF02902.19 ORX70647.1 - 6.2e-20 72.0 0.1 1e-19 71.2 0.1 1.4 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Josephin PF02099.17 ORX70647.1 - 0.0014 18.7 0.1 0.0018 18.4 0.1 1.2 1 0 0 1 1 1 1 Josephin Peptidase_C57 PF03290.13 ORX70647.1 - 0.039 12.7 0.1 0.04 12.7 0.1 1.1 1 0 0 1 1 1 0 Vaccinia virus I7 processing peptidase FliJ PF02050.16 ORX70649.1 - 0.003 17.8 9.3 0.003 17.8 9.3 6.3 3 3 1 5 5 5 1 Flagellar FliJ protein Fez1 PF06818.15 ORX70649.1 - 0.0037 17.8 27.5 0.0037 17.8 27.5 4.0 1 1 3 4 4 4 1 Fez1 Baculo_PEP_C PF04513.12 ORX70649.1 - 0.29 11.2 15.2 0.68 10.0 0.2 4.5 2 2 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ANAPC10 PF03256.16 ORX70650.1 - 1.9e-31 109.2 0.0 9.6e-30 103.6 0.0 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PC_rep PF01851.22 ORX70651.1 - 9.4e-31 104.7 24.7 2.3e-09 37.2 0.1 8.7 8 0 0 8 8 8 6 Proteasome/cyclosome repeat RPN2_C PF18004.1 ORX70651.1 - 1.7e-24 86.5 0.1 3e-21 76.0 0.0 2.3 1 1 1 2 2 2 2 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 ORX70651.1 - 1e-20 73.9 0.8 6.3e-13 48.9 0.0 5.2 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 ORX70651.1 - 0.0048 17.0 0.7 1.7 9.1 0.1 4.1 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 ORX70651.1 - 0.0051 17.3 0.2 0.36 11.4 0.0 3.4 2 0 0 2 2 2 1 HEAT-like repeat HEAT_PBS PF03130.16 ORX70651.1 - 0.23 12.3 1.6 51 4.9 0.0 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF2620 PF10941.8 ORX70651.1 - 0.33 11.1 2.1 2.1 8.5 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF2620 GTP_EFTU PF00009.27 ORX70652.1 - 6.2e-42 143.3 0.0 9e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ORX70652.1 - 8.3e-24 83.5 0.0 2.1e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ORX70652.1 - 8.3e-24 83.7 0.0 1.9e-23 82.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFTUD2 PF16004.5 ORX70652.1 - 2.8e-15 57.0 4.8 2.5e-14 53.9 4.8 2.3 1 1 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_II PF14492.6 ORX70652.1 - 1.8e-07 31.1 0.0 4.6e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ORX70652.1 - 1.8e-06 28.2 0.0 3.9e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX70652.1 - 4.6e-05 23.5 0.1 8.3e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX70652.1 - 0.068 12.6 0.1 2.2 7.7 0.1 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_membrane PF00664.23 ORX70653.1 - 1.4e-74 251.2 28.6 1.3e-40 139.7 9.5 2.7 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX70653.1 - 1.2e-51 174.8 0.0 1.1e-30 106.9 0.0 3.1 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ORX70653.1 - 4.9e-11 42.5 2.9 0.00024 20.6 0.0 4.2 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX70653.1 - 4.1e-07 30.1 0.5 0.033 14.3 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase DUF87 PF01935.17 ORX70653.1 - 2.5e-05 24.5 0.8 0.063 13.4 0.1 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_29 PF13555.6 ORX70653.1 - 8.4e-05 22.2 0.4 0.34 10.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX70653.1 - 8.9e-05 22.9 0.7 0.36 11.2 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX70653.1 - 0.00024 21.1 0.1 0.23 11.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ORX70653.1 - 0.00095 19.1 1.5 9.1 6.0 0.0 3.4 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 ORX70653.1 - 0.0025 17.0 0.1 1.4 8.0 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 ORX70653.1 - 0.0054 16.1 0.0 0.079 12.3 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family IstB_IS21 PF01695.17 ORX70653.1 - 0.0063 16.3 0.1 1.5 8.5 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein Dynamin_N PF00350.23 ORX70653.1 - 0.0073 16.4 2.6 0.058 13.4 0.3 2.5 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 ORX70653.1 - 0.026 14.8 1.7 2.9 8.1 0.0 3.5 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 ORX70653.1 - 0.028 13.3 0.3 0.87 8.4 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 ORX70653.1 - 0.04 13.4 0.1 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_23 PF13476.6 ORX70653.1 - 0.086 13.3 0.0 6.5 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ORX70653.1 - 0.11 12.7 2.0 12 6.2 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ORX70653.1 - 0.16 11.1 0.3 5.1 6.2 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain MTABC_N PF16185.5 ORX70653.1 - 0.22 11.0 7.3 0.087 12.3 4.1 2.0 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region ABC_membrane PF00664.23 ORX70654.1 - 1.5e-47 162.5 18.8 1.6e-28 100.1 2.1 3.3 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX70654.1 - 7.9e-33 113.9 0.0 2.3e-17 63.8 0.0 4.0 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX70654.1 - 1.5e-07 31.1 5.1 0.027 13.9 0.6 4.4 4 1 1 5 5 5 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX70654.1 - 2.4e-06 27.6 0.4 0.1 12.7 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX70654.1 - 2.4e-05 24.0 0.6 0.036 13.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 ORX70654.1 - 2.7e-05 24.4 0.2 0.18 11.9 0.0 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 ORX70654.1 - 0.00018 21.5 0.2 0.15 12.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX70654.1 - 0.00079 19.9 0.0 2.1 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ORX70654.1 - 0.0012 19.4 2.1 0.45 11.0 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ORX70654.1 - 0.0017 18.2 0.4 1.1 9.0 0.1 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 ORX70654.1 - 0.011 15.4 0.1 5 6.8 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_15 PF13175.6 ORX70654.1 - 0.027 14.2 0.0 0.7 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 ORX70654.1 - 0.053 12.5 0.0 6.2 5.7 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ORX70654.1 - 0.057 13.5 2.3 0.63 10.1 0.2 2.6 2 0 0 2 2 2 0 Dynamin family Sigma54_activat PF00158.26 ORX70654.1 - 0.11 12.2 0.0 4.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 ORX70654.1 - 0.16 12.3 0.5 17 5.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 ORX70654.1 - 0.16 11.1 0.1 7.8 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ORX70654.1 - 0.17 12.3 0.1 17 5.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DEAD PF00270.29 ORX70654.1 - 0.22 11.3 1.4 1.6 8.5 0.0 2.8 3 1 0 3 3 3 0 DEAD/DEAH box helicase Peptidase_C48 PF02902.19 ORX70655.1 - 2.7e-06 27.4 0.1 0.002 18.0 0.0 2.2 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain CLP1_P PF16575.5 ORX70656.1 - 5.7e-33 114.3 0.0 8e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 ORX70656.1 - 2.4e-30 104.6 0.0 4.2e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 ORX70656.1 - 1.4e-26 93.2 0.0 3.6e-26 91.9 0.0 1.7 2 0 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 ABC_tran PF00005.27 ORX70657.1 - 1.6e-45 155.0 0.0 8.7e-28 97.5 0.0 2.6 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX70657.1 - 4.2e-08 32.9 0.2 0.13 11.7 0.0 3.5 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX70657.1 - 1.5e-06 28.3 0.4 0.034 14.2 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX70657.1 - 7e-06 25.7 0.3 0.02 14.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX70657.1 - 0.00018 22.0 0.0 0.43 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 ORX70657.1 - 0.00036 20.6 0.3 0.038 14.0 0.1 2.3 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 ORX70657.1 - 0.00062 19.7 0.4 0.97 9.3 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase ABC_membrane PF00664.23 ORX70657.1 - 0.00065 19.4 13.1 0.018 14.7 0.3 2.9 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.6 ORX70657.1 - 0.0013 18.6 1.2 1.3 8.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX70657.1 - 0.0017 18.9 0.3 2 8.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 ORX70657.1 - 0.0065 16.6 1.2 0.16 12.1 0.2 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_15 PF13175.6 ORX70657.1 - 0.015 15.0 0.2 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF815 PF05673.13 ORX70657.1 - 0.017 14.3 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 ORX70657.1 - 0.03 13.4 0.2 0.56 9.2 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein MeaB PF03308.16 ORX70657.1 - 0.031 13.2 0.6 0.086 11.8 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 ORX70657.1 - 0.037 13.2 2.0 4.3 6.4 0.0 3.4 3 1 0 3 3 3 0 NB-ARC domain AAA_30 PF13604.6 ORX70657.1 - 0.044 13.5 0.1 14 5.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ORX70657.1 - 0.048 12.9 0.4 4.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 ORX70657.1 - 0.05 13.3 0.1 2.6 7.7 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX70657.1 - 0.091 13.2 0.2 9.6 6.7 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_22 PF13401.6 ORX70657.1 - 0.099 12.9 1.0 12 6.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 ORX70657.1 - 0.17 11.4 2.3 11 5.5 0.0 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_25 PF13481.6 ORX70657.1 - 0.3 10.7 1.2 4.6 6.8 0.2 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX70657.1 - 0.36 10.7 1.9 9.3 6.1 0.0 3.2 3 0 0 3 3 3 0 NACHT domain Peptidase_M16_C PF05193.21 ORX70659.1 - 0.0026 17.8 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain adh_short PF00106.25 ORX70660.1 - 1.4e-49 168.2 3.6 2e-49 167.7 3.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX70660.1 - 5.4e-33 114.5 1.1 7.1e-33 114.1 1.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX70660.1 - 2.7e-08 33.9 1.0 5.8e-08 32.9 1.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX70660.1 - 9.7e-07 28.5 0.1 1.4e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ORX70660.1 - 0.00043 19.8 0.0 0.0061 16.0 0.0 2.0 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ORX70660.1 - 0.00053 19.5 0.1 0.00077 18.9 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_2 PF03446.15 ORX70660.1 - 0.032 14.4 0.2 0.059 13.5 0.2 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase DFP PF04127.15 ORX70660.1 - 0.059 13.2 1.0 0.082 12.7 1.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Abhydrolase_3 PF07859.13 ORX70661.1 - 4e-32 111.8 0.0 1.7e-20 73.8 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX70661.1 - 0.046 12.6 0.0 0.084 11.7 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase Fungal_trans PF04082.18 ORX70662.1 - 0.17 10.9 0.0 0.7 8.9 0.0 1.9 2 0 0 2 2 2 0 Fungal specific transcription factor domain PRK PF00485.18 ORX70664.1 - 2.7e-06 27.3 0.0 3.4e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ORX70664.1 - 2.2e-05 25.0 0.0 3.6e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX70664.1 - 0.00017 21.7 0.1 0.0015 18.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX70664.1 - 0.032 14.0 0.1 0.075 12.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 ORX70664.1 - 0.037 14.1 0.0 0.09 12.9 0.0 1.6 1 1 0 1 1 1 0 Torsin Zeta_toxin PF06414.12 ORX70664.1 - 0.038 13.3 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 ORX70664.1 - 0.11 11.7 0.2 0.18 10.9 0.0 1.4 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.18 ORX70664.1 - 0.12 12.1 0.0 0.63 9.7 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 ORX70664.1 - 0.13 12.7 0.0 0.49 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX70664.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Adenine_glyco PF03352.13 ORX70664.1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Methyladenine glycosylase LNS2 PF08235.13 ORX70665.1 - 1.3e-66 224.3 0.0 7e-66 221.9 0.0 2.1 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_mid PF16876.5 ORX70665.1 - 0.0002 21.4 0.0 0.0005 20.2 0.0 1.7 1 1 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain CPSase_L_D2 PF02786.17 ORX70666.1 - 5.2e-108 359.4 0.0 1.5e-83 279.4 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 ORX70666.1 - 6.2e-38 129.9 0.0 1.4e-37 128.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 ORX70666.1 - 2.7e-17 62.9 0.0 2.9e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ORX70666.1 - 7.3e-16 58.3 0.1 7.5e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 ORX70666.1 - 3.7e-08 33.2 0.0 0.0035 17.1 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 ORX70666.1 - 2.1e-06 27.3 0.0 0.0021 17.6 0.0 2.8 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 ORX70666.1 - 6.9e-06 26.2 0.0 0.00011 22.3 0.0 2.6 2 0 0 2 2 2 1 MGS-like domain Epimerase PF01370.21 ORX70666.1 - 0.059 12.8 0.0 1.2 8.6 0.0 2.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HTH_26 PF13443.6 ORX70666.1 - 0.074 13.5 0.0 10 6.7 0.0 2.7 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain FBPase_3 PF01950.16 ORX70666.1 - 0.12 11.6 0.0 0.74 8.9 0.0 2.0 2 0 0 2 2 2 0 Fructose-1,6-bisphosphatase Peptidase_M17_N PF02789.17 ORX70666.1 - 0.54 10.1 3.4 0.28 11.1 0.2 2.2 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain UvrD-helicase PF00580.21 ORX70667.1 - 4.2e-21 75.8 0.1 6e-21 75.3 0.1 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ORX70667.1 - 6.4e-15 55.4 0.0 9.1e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ORX70667.1 - 8.4e-12 45.6 0.4 1.5e-11 44.9 0.4 1.4 1 0 0 1 1 1 1 AAA domain LSDAT_euk PF18139.1 ORX70668.1 - 0.079 12.3 0.0 0.09 12.2 0.0 1.1 1 0 0 1 1 1 0 SLOG in TRPM DUF4743 PF15916.5 ORX70669.1 - 2e-05 24.5 0.0 3.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) RED_N PF07808.13 ORX70670.1 - 1.7e-25 90.0 7.0 4.5e-25 88.6 7.0 1.6 1 0 0 1 1 1 1 RED-like protein N-terminal region DUF719 PF05334.13 ORX70671.1 - 0.3 11.3 2.1 0.54 10.4 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Fibrinogen_BP PF08017.11 ORX70672.1 - 4.3e-28 97.9 18.0 2.8e-15 55.7 13.6 2.2 1 1 1 2 2 2 2 Fibrinogen binding protein Speriolin_N PF15058.6 ORX70672.1 - 0.21 11.7 7.6 2.4e+02 1.7 7.2 5.1 2 2 0 2 2 2 0 Speriolin N terminus ATP-synt_10 PF05176.14 ORX70675.1 - 1.1e-42 146.0 0.0 1.4e-42 145.7 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein PRCC PF10253.9 ORX70676.1 - 2.6e-16 61.1 8.8 2.6e-16 61.1 8.8 2.6 1 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting OCRE PF17780.1 ORX70676.1 - 0.0011 19.0 9.9 0.0027 17.7 9.9 1.7 1 1 0 1 1 1 1 OCRE domain CD24 PF14984.6 ORX70676.1 - 0.28 11.4 4.8 0.5 10.6 3.1 2.4 2 0 0 2 2 2 0 CD24 protein Uso1_p115_head PF04869.14 ORX70678.1 - 5.2e-35 121.1 0.0 3.1e-32 112.0 0.0 3.1 1 1 2 3 3 3 2 Uso1 / p115 like vesicle tethering protein, head region Arm_vescicular PF18770.1 ORX70678.1 - 3.6e-07 30.0 0.0 8.2e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Arm PF00514.23 ORX70678.1 - 0.00094 19.1 0.3 0.19 11.8 0.0 4.2 3 1 1 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ORX70678.1 - 0.014 15.6 0.4 0.32 11.4 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat RasGEF_N_2 PF14663.6 ORX70678.1 - 0.093 13.1 1.7 15 6.1 0.0 2.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain FlaC_arch PF05377.11 ORX70678.1 - 0.47 10.9 4.9 5.9 7.4 4.9 2.7 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1840 PF08895.11 ORX70678.1 - 0.55 10.6 0.0 0.55 10.6 0.0 4.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) Atx10homo_assoc PF09759.9 ORX70678.1 - 4.8 7.3 8.4 19 5.4 0.0 3.7 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Nup160 PF11715.8 ORX70680.1 - 1.2e-14 53.9 0.0 1.9e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 BRO1 PF03097.18 ORX70681.1 - 7.2e-19 67.9 0.0 1.1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain S_2TMBeta PF18153.1 ORX70681.1 - 0.067 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain PPP4R2 PF09184.11 ORX70683.1 - 0.31 10.6 19.2 0.55 9.8 19.2 1.3 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 ORX70683.1 - 0.54 8.3 26.1 0.78 7.8 26.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC27 PF09507.10 ORX70683.1 - 0.81 9.0 16.3 1.2 8.5 16.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIA PF03153.13 ORX70683.1 - 1.2 9.0 15.5 1.6 8.7 15.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 ORX70683.1 - 7.7 5.2 8.1 11 4.7 8.1 1.2 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.11 ORX70683.1 - 8.8 5.0 8.8 13 4.5 8.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PBP PF01161.20 ORX70684.1 - 1.3e-11 44.9 0.1 2.3e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF202 PF02656.15 ORX70685.1 - 6.8e-07 29.6 0.4 1.8e-06 28.3 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) LDB19 PF13002.7 ORX70685.1 - 0.00099 18.9 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 ORX70685.1 - 0.0037 17.3 0.0 0.038 14.1 0.1 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain DUF4173 PF13777.6 ORX70685.1 - 0.084 12.3 2.3 0.14 11.6 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) CBM_14 PF01607.24 ORX70687.1 - 1.1e-08 35.2 2.8 3.4e-08 33.5 2.8 1.9 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain NUDIX PF00293.28 ORX70688.1 - 5.2e-18 65.3 0.0 9.1e-18 64.6 0.0 1.4 1 1 1 2 2 2 1 NUDIX domain Glyco_tran_10_N PF17039.5 ORX70688.1 - 0.12 12.8 0.3 0.3 11.6 0.3 1.6 1 1 0 1 1 1 0 Fucosyltransferase, N-terminal UPF0047 PF01894.17 ORX70689.1 - 5e-36 123.4 0.0 5.8e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Tim17 PF02466.19 ORX70690.1 - 0.017 15.5 0.7 0.08 13.3 0.7 2.1 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Drf_GBD PF06371.13 ORX70690.1 - 0.077 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Far-17a_AIG1 PF04750.14 ORX70691.1 - 3.3e-07 29.8 13.8 3.3e-07 29.8 13.8 2.4 2 1 1 3 3 3 1 FAR-17a/AIG1-like protein DUF639 PF04842.12 ORX70691.1 - 0.2 11.1 2.2 0.22 10.9 0.2 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) Erf4 PF10256.9 ORX70692.1 - 0.00013 22.1 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF4646 PF15496.6 ORX70692.1 - 0.00047 20.8 0.0 0.00077 20.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) Retinal PF15449.6 ORX70692.1 - 5 4.8 5.3 6 4.5 5.3 1.0 1 0 0 1 1 1 0 Retinal protein P5CR_dimer PF14748.6 ORX70693.1 - 3.4e-34 117.2 0.7 6.7e-34 116.2 0.7 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ORX70693.1 - 3.2e-08 34.0 1.4 2.5e-07 31.2 1.4 2.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PTS_IIB PF02302.17 ORX70693.1 - 0.02 15.6 1.0 0.12 13.1 0.2 2.4 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit Adeno_E3 PF06040.11 ORX70693.1 - 0.058 13.6 0.0 0.16 12.1 0.0 1.7 2 0 0 2 2 2 0 Adenovirus E3 protein Filament PF00038.21 ORX70694.1 - 0.0052 16.4 7.3 0.0078 15.8 7.3 1.2 1 0 0 1 1 1 1 Intermediate filament protein Tox-ODYAM1 PF15642.6 ORX70694.1 - 0.3 10.0 2.1 0.42 9.5 2.1 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Borrelia_P83 PF05262.11 ORX70694.1 - 2 6.8 5.7 2.7 6.4 5.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Myosin_head PF00063.21 ORX70695.1 - 7.8e-257 853.9 0.0 1.3e-256 853.1 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 ORX70695.1 - 7.3e-28 96.9 3.0 3.7e-27 94.6 3.0 2.4 1 0 0 1 1 1 1 DIL domain IQ PF00612.27 ORX70695.1 - 2e-20 70.6 32.1 8.7e-05 22.0 0.6 7.2 7 0 0 7 7 7 6 IQ calmodulin-binding motif AAA_22 PF13401.6 ORX70695.1 - 0.032 14.5 0.0 0.032 14.5 0.0 3.1 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 ORX70695.1 - 0.077 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ORX70695.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ish1 PF10281.9 ORX70695.1 - 0.14 12.5 0.1 5.2 7.4 0.0 2.9 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein AAA_16 PF13191.6 ORX70695.1 - 0.19 12.1 0.0 0.19 12.1 0.0 3.3 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 ORX70695.1 - 3.2 8.3 0.0 3.2 8.3 0.0 3.4 2 1 0 2 2 2 0 ABC transporter Prominin PF05478.11 ORX70695.1 - 7.4 4.4 12.5 4.7 5.0 10.4 1.7 1 1 0 1 1 1 0 Prominin RSN1_7TM PF02714.15 ORX70698.1 - 1.9e-48 165.2 30.6 3e-48 164.5 30.6 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX70698.1 - 1.9e-26 92.7 1.4 1.9e-26 92.7 1.4 3.3 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX70698.1 - 1.1e-18 68.1 0.1 2.9e-18 66.7 0.1 1.8 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF4357 PF14267.6 ORX70699.1 - 0.075 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) Glyco_hydro_18 PF00704.28 ORX70701.1 - 6.9e-70 236.2 3.7 8.3e-70 236.0 3.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70701.1 - 1.3e-05 25.1 3.2 3.9e-05 23.5 3.2 1.8 1 0 0 1 1 1 1 Carbohydrate binding domain (family 19) Putative_G5P PF17426.2 ORX70701.1 - 0.12 12.5 0.0 0.42 10.7 0.0 1.8 2 0 0 2 2 2 0 Putative Gamma DNA binding protein G5P Glyco_hydro_18 PF00704.28 ORX70702.1 - 8.8e-70 235.9 5.5 1e-69 235.7 5.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_18 PF00704.28 ORX70703.1 - 2.6e-70 237.6 4.3 3e-70 237.4 4.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Acyl-CoA_dh_1 PF00441.24 ORX70704.1 - 1.6e-46 158.3 0.5 1.6e-46 158.3 0.5 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX70704.1 - 3.3e-25 88.1 0.0 9.3e-25 86.7 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX70704.1 - 3.5e-21 75.9 0.1 3.5e-21 75.9 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX70704.1 - 9.9e-21 74.5 0.1 3e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain HpaB_N PF11794.8 ORX70704.1 - 0.019 14.6 0.1 0.089 12.4 0.2 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.11 ORX70704.1 - 0.17 11.9 0.0 0.59 10.2 0.0 1.9 1 0 0 1 1 1 0 Staphylococcal AgrD protein NDUF_B7 PF05676.13 ORX70705.1 - 5.2e-31 106.2 7.5 6.2e-31 105.9 7.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 ORX70705.1 - 0.016 15.2 4.2 0.02 14.9 4.1 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like RasGEF PF00617.19 ORX70706.1 - 9.3e-46 156.2 0.4 1.9e-45 155.3 0.2 1.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ORX70706.1 - 2.9e-13 49.9 0.0 6.7e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif ANAPC5 PF12862.7 ORX70707.1 - 9.5e-07 28.8 2.2 0.015 15.3 0.1 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 5 Glyco_hydro_18 PF00704.28 ORX70709.1 - 2.4e-42 145.8 6.4 2.5e-41 142.4 6.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70709.1 - 3.1e-05 23.9 21.6 8.8e-05 22.4 20.8 2.2 2 1 0 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX70709.1 - 0.31 11.2 4.7 0.62 10.3 4.7 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Glyco_hydro_18 PF00704.28 ORX70710.1 - 1e-65 222.5 7.5 1.3e-65 222.2 7.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70710.1 - 0.023 14.6 31.9 2.9 8.0 31.9 3.1 1 1 0 1 1 1 0 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX70710.1 - 0.21 11.8 6.4 0.38 10.9 6.4 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Glyco_hydro_18 PF00704.28 ORX70711.1 - 8.2e-64 216.3 4.5 1e-63 216.0 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70711.1 - 9.5e-07 28.7 14.2 9.5e-07 28.7 14.2 2.3 1 1 1 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX70711.1 - 0.049 13.8 5.9 0.092 12.9 5.9 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Glyco_hydro_18 PF00704.28 ORX70712.1 - 2.3e-58 198.4 0.0 2.7e-58 198.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX70712.1 - 0.04 13.9 4.9 0.099 12.6 4.9 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) FA_hydroxylase PF04116.13 ORX70713.1 - 1.5e-23 83.6 17.9 1.5e-23 83.6 17.9 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF1980 PF09323.10 ORX70714.1 - 0.012 15.5 0.3 0.012 15.5 0.3 2.6 2 1 2 4 4 4 0 Domain of unknown function (DUF1980) DUF1057 PF06342.12 ORX70715.1 - 0.2 10.7 0.1 0.27 10.2 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF373 PF04123.13 ORX70715.1 - 0.33 10.3 8.3 0.53 9.7 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Septin PF00735.18 ORX70716.1 - 1.6e-111 372.1 0.0 1.6e-111 372.1 0.0 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ORX70716.1 - 8.9e-08 32.2 1.3 1.4e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX70716.1 - 7e-05 22.8 0.2 7e-05 22.8 0.2 2.9 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 ORX70716.1 - 0.00012 21.4 0.0 0.00012 21.4 0.0 1.9 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 ORX70716.1 - 0.00069 19.7 3.4 0.13 12.3 0.0 3.3 3 0 0 3 3 3 1 Dynamin family AAA_22 PF13401.6 ORX70716.1 - 0.0017 18.6 0.2 0.0095 16.2 0.0 2.4 2 1 1 3 3 3 1 AAA domain Roc PF08477.13 ORX70716.1 - 0.0033 17.6 0.0 0.0087 16.3 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ORX70716.1 - 0.0058 17.0 0.6 0.018 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain IIGP PF05049.13 ORX70716.1 - 0.0067 15.5 0.1 0.0067 15.5 0.1 2.0 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 ORX70716.1 - 0.011 16.3 6.5 0.023 15.2 0.6 2.5 2 1 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 ORX70716.1 - 0.015 15.0 0.1 0.063 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 ORX70716.1 - 0.026 14.1 3.8 0.067 12.7 0.0 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 ORX70716.1 - 0.042 13.6 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 ORX70716.1 - 0.068 12.8 1.3 0.21 11.2 0.0 2.4 3 0 0 3 3 3 0 Ras family HAUS6_N PF14661.6 ORX70716.1 - 0.23 11.0 7.5 0.36 10.4 7.5 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus AAA_23 PF13476.6 ORX70716.1 - 0.28 11.7 5.2 14 6.1 3.4 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 ORX70716.1 - 0.35 9.8 3.7 8.2 5.3 1.9 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Selenoprotein_S PF06936.11 ORX70716.1 - 0.73 9.6 8.4 1.1 9.0 8.4 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) KAP_NTPase PF07693.14 ORX70716.1 - 1.3 8.2 6.2 12 5.0 0.0 2.4 3 0 0 3 3 3 0 KAP family P-loop domain Exonuc_VII_L PF02601.15 ORX70716.1 - 1.8 8.1 7.5 2.8 7.4 7.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cgr1 PF03879.14 ORX70716.1 - 4.5 7.7 16.1 9.1 6.7 16.1 1.5 1 0 0 1 1 1 0 Cgr1 family DUF1640 PF07798.11 ORX70717.1 - 3.2e-59 199.9 10.6 3.6e-59 199.7 10.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.18 ORX70717.1 - 2.9e-05 24.2 0.8 0.00011 22.4 0.7 2.1 2 1 0 2 2 2 1 Homeobox associated leucine zipper HMMR_C PF15908.5 ORX70717.1 - 0.003 17.9 6.6 0.046 14.0 0.2 2.4 1 1 2 3 3 3 2 Hyaluronan mediated motility receptor C-terminal BOF PF04076.13 ORX70717.1 - 0.02 15.0 0.1 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein Attacin_C PF03769.15 ORX70717.1 - 0.082 13.2 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Attacin, C-terminal region BST2 PF16716.5 ORX70717.1 - 0.17 12.5 10.3 0.43 11.2 3.0 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Baculo_PEP_C PF04513.12 ORX70717.1 - 0.21 11.7 2.1 0.59 10.2 0.7 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 ORX70717.1 - 0.41 11.1 8.1 7.3 7.1 2.2 3.3 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Fungal_TACC PF12709.7 ORX70717.1 - 0.44 11.0 7.4 0.61 10.6 1.9 2.4 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DivIC PF04977.15 ORX70717.1 - 0.45 10.3 10.3 0.11 12.3 2.7 2.5 1 1 1 2 2 2 0 Septum formation initiator Uso1_p115_C PF04871.13 ORX70717.1 - 0.96 9.8 10.8 0.61 10.5 3.5 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Remorin_C PF03763.13 ORX70717.1 - 1.7 8.5 11.3 0.36 10.7 8.0 1.6 2 0 0 2 2 2 0 Remorin, C-terminal region YabA PF06156.13 ORX70717.1 - 2.1 9.0 8.1 5.2 7.8 6.0 2.3 1 1 2 3 3 3 0 Initiation control protein YabA Lzipper-MIP1 PF14389.6 ORX70717.1 - 2.2 8.6 8.1 7.4 6.9 4.5 3.0 2 2 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Carboxyl_trans PF01039.22 ORX70718.1 - 2.3e-143 478.4 0.1 3.6e-143 477.8 0.1 1.3 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ORX70718.1 - 0.019 14.5 0.3 4 6.9 0.1 2.4 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) WXG100 PF06013.12 ORX70718.1 - 0.12 12.6 2.1 2.9 8.2 0.1 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG MbeD_MobD PF04899.12 ORX70718.1 - 0.21 11.7 0.4 0.45 10.7 0.4 1.6 1 0 0 1 1 1 0 MbeD/MobD like FSH1 PF03959.13 ORX70719.1 - 4.8e-53 180.0 0.0 5.4e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 ORX70719.1 - 1.2e-05 25.0 0.0 0.0014 18.2 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 ORX70719.1 - 0.00044 20.1 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ORX70719.1 - 0.0039 16.5 0.1 0.12 11.6 0.0 2.6 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX70719.1 - 0.019 14.6 0.3 2.1 7.9 0.1 2.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 ORX70719.1 - 0.026 14.4 0.1 0.055 13.3 0.0 1.5 2 0 0 2 2 2 0 Serine hydrolase F-box-like PF12937.7 ORX70720.1 - 0.0055 16.6 0.2 0.019 14.8 0.2 1.9 1 0 0 1 1 1 1 F-box-like UDPGP PF01704.18 ORX70721.1 - 4.9e-55 186.8 0.0 6.7e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 ORX70721.1 - 0.019 15.3 0.0 0.047 14.0 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain Abhydrolase_3 PF07859.13 ORX70723.1 - 2.3e-21 76.7 0.0 4.5e-21 75.7 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Vps51 PF08700.11 ORX70724.1 - 1.7e-11 44.1 0.8 3.2e-11 43.1 0.3 1.7 2 0 0 2 2 2 1 Vps51/Vps67 Dor1 PF04124.12 ORX70724.1 - 0.00097 17.9 0.3 0.0014 17.4 0.3 1.1 1 0 0 1 1 1 1 Dor1-like family Zw10 PF06248.13 ORX70724.1 - 0.016 13.8 0.7 0.021 13.4 0.7 1.1 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 CHD5 PF04420.14 ORX70724.1 - 0.03 14.2 1.5 0.051 13.4 0.2 2.0 2 0 0 2 2 2 0 CHD5-like protein Laminin_II PF06009.12 ORX70724.1 - 0.039 14.0 0.6 0.092 12.8 0.5 1.7 1 1 0 1 1 1 0 Laminin Domain II Aminotran_1_2 PF00155.21 ORX70725.1 - 2.4e-77 260.6 0.0 2.7e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II F-box-like PF12937.7 ORX70726.1 - 0.0029 17.5 1.0 0.011 15.6 1.0 2.0 1 1 0 1 1 1 1 F-box-like 3Beta_HSD PF01073.19 ORX70728.1 - 0.039 13.0 0.1 0.22 10.5 0.0 1.8 1 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family KH_1 PF00013.29 ORX70730.1 - 1.4e-111 364.4 42.6 3e-14 52.6 0.7 14.8 15 1 0 15 15 15 13 KH domain KH_2 PF07650.17 ORX70730.1 - 9.4e-17 60.6 20.5 0.033 14.0 0.3 9.9 7 1 2 9 9 9 6 KH domain MOEP19 PF16005.5 ORX70730.1 - 1.3e-05 25.1 0.3 0.099 12.7 0.0 4.7 5 0 0 5 5 5 2 KH-like RNA-binding domain KH_4 PF13083.6 ORX70730.1 - 0.00094 19.0 24.5 3.8 7.4 0.0 8.8 9 1 1 10 10 10 4 KH domain YbbR PF07949.12 ORX70730.1 - 0.15 12.4 13.5 6.1 7.2 0.1 6.1 7 0 0 7 7 7 0 YbbR-like protein KH_5 PF13184.6 ORX70730.1 - 4.7 7.4 15.4 16 5.7 0.0 6.7 9 0 0 9 9 9 0 NusA-like KH domain Sulfate_transp PF00916.20 ORX70731.1 - 9.1e-95 317.6 12.9 1.3e-94 317.1 12.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX70731.1 - 4e-08 32.9 0.0 7.9e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX70731.1 - 0.0044 17.4 3.7 0.0044 17.4 3.7 3.3 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily PMP1_2 PF08114.11 ORX70732.1 - 0.029 14.1 1.6 0.08 12.7 1.6 1.7 1 0 0 1 1 1 0 ATPase proteolipid family DUF2681 PF10883.8 ORX70732.1 - 0.1 13.0 0.2 0.19 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Phage_holin_3_6 PF07332.11 ORX70732.1 - 3.9 7.5 8.9 1.3 9.1 0.1 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III WD40 PF00400.32 ORX70733.1 - 2.7e-40 135.6 18.7 1.8e-09 38.1 0.3 7.3 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70733.1 - 5.7e-05 23.3 2.4 0.26 11.6 0.1 4.2 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX70733.1 - 0.0021 16.8 5.6 3.1 6.3 0.0 4.6 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX70733.1 - 0.04 12.7 0.0 9.5 4.8 0.0 2.9 1 1 3 4 4 4 0 Nup133 N terminal like RCC1 PF00415.18 ORX70734.1 - 9.5e-18 64.6 8.1 1.2e-05 25.8 0.0 7.2 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX70734.1 - 3.4e-15 55.4 19.5 1.4e-08 34.3 1.0 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat DUF3390 PF11870.8 ORX70734.1 - 0.033 14.6 0.3 0.17 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) CPSF_A PF03178.15 ORX70735.1 - 6.2e-65 219.6 0.0 1.5e-64 218.4 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ORX70735.1 - 5.2e-31 107.8 0.0 1.1e-30 106.7 0.0 1.5 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Astro_capsid_p PF12226.8 ORX70735.1 - 3.5 6.7 4.6 6 5.9 4.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PSS PF03034.15 ORX70736.1 - 4.2e-97 325.2 15.4 9.6e-97 324.0 11.2 2.7 2 1 0 2 2 2 1 Phosphatidyl serine synthase Peptidase_M17 PF00883.21 ORX70737.1 - 3.3e-57 194.1 0.0 4.2e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Myb_DNA-bind_4 PF13837.6 ORX70738.1 - 2e-10 40.9 0.5 3.7e-10 40.1 0.5 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 ORX70738.1 - 0.00025 21.0 2.4 0.00047 20.2 2.4 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX70738.1 - 0.016 15.4 2.1 0.029 14.6 2.1 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 ORX70738.1 - 0.02 15.2 0.1 0.056 13.8 0.1 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pro-rich PF15240.6 ORX70738.1 - 0.21 11.9 33.6 0.35 11.1 33.6 1.4 1 0 0 1 1 1 0 Proline-rich TFIIA PF03153.13 ORX70738.1 - 0.26 11.3 20.2 0.32 11.0 20.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myb_DNA-bind_3 PF12776.7 ORX70738.1 - 0.29 12.2 2.7 0.95 10.5 2.7 1.9 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain SPX PF03105.19 ORX70738.1 - 1.8 8.4 11.8 2.6 7.9 11.8 1.2 1 0 0 1 1 1 0 SPX domain eIF2A PF08662.11 ORX70740.1 - 4e-83 278.1 0.0 5.2e-78 261.4 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ORX70740.1 - 1.8e-05 24.9 0.0 0.0059 16.9 0.0 3.8 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX70740.1 - 0.0019 19.0 0.3 9.9 7.2 0.0 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.12 ORX70740.1 - 0.042 13.8 0.8 1.8 8.6 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat CDV3 PF15359.6 ORX70740.1 - 1.8 9.1 6.8 0.1 13.1 0.7 2.0 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 GYF PF02213.16 ORX70742.1 - 9.7e-18 63.6 0.5 1.9e-17 62.6 0.5 1.5 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 ORX70742.1 - 0.0018 18.0 0.3 0.0051 16.6 0.3 1.8 1 0 0 1 1 1 1 GYF domain 2 Clat_adaptor_s PF01217.20 ORX70743.1 - 6.5e-56 188.2 3.4 7.2e-56 188.1 3.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain N2227 PF07942.12 ORX70743.1 - 0.0042 16.3 0.1 0.0043 16.3 0.1 1.2 1 0 0 1 1 1 1 N2227-like protein DUF1729 PF08354.10 ORX70744.1 - 7.4e-110 367.2 0.0 1.8e-92 310.0 0.0 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX70744.1 - 4.8e-51 173.3 0.0 9e-51 172.4 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX70744.1 - 1.8e-50 172.3 0.0 5.9e-49 167.3 0.0 2.7 2 0 0 2 2 2 1 Acyl transferase domain FAS_I_H PF18314.1 ORX70744.1 - 1.1e-32 113.3 0.1 9.9e-26 90.6 0.0 2.4 1 1 1 2 2 2 2 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX70744.1 - 1.2e-27 96.0 0.2 3.6e-27 94.4 0.2 1.9 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX70744.1 - 1.1e-24 86.9 0.3 2e-13 50.4 0.0 2.9 2 1 1 3 3 3 2 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX70744.1 - 1.2e-23 84.0 0.3 3e-23 82.7 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX70744.1 - 1.6e-14 54.2 0.1 3.9e-14 53.0 0.1 1.7 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX70744.1 - 1.1e-11 44.8 0.0 3.1e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX70744.1 - 5.4e-10 39.5 0.0 3.1e-08 33.8 0.0 2.6 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX70744.1 - 9.5e-06 25.6 0.2 3.4e-05 23.9 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta Thiolase_N PF00108.23 ORX70744.1 - 0.0007 19.0 0.2 0.0017 17.8 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain NMO PF03060.15 ORX70744.1 - 0.1 11.9 0.0 8.1 5.7 0.0 2.7 3 0 0 3 3 3 0 Nitronate monooxygenase DUF465 PF04325.13 ORX70744.1 - 0.14 12.2 0.1 0.33 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF465) CH_2 PF06294.11 ORX70745.1 - 0.015 15.4 0.0 0.017 15.2 0.0 1.0 1 0 0 1 1 1 0 CH-like domain in sperm protein CENP-F_leu_zip PF10473.9 ORX70746.1 - 1.5e-06 28.3 92.3 0.031 14.3 5.4 7.6 1 1 6 7 7 7 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 ORX70746.1 - 6.2e-06 26.0 85.4 0.026 14.1 15.8 5.9 1 1 4 5 5 5 5 Intermediate filament protein Spc7 PF08317.11 ORX70746.1 - 0.00016 20.7 104.2 0.028 13.3 16.5 5.9 1 1 5 6 6 6 4 Spc7 kinetochore protein APG6_N PF17675.1 ORX70746.1 - 0.00017 22.1 16.6 0.00017 22.1 16.6 7.5 1 1 4 6 6 4 1 Apg6 coiled-coil region DUF3450 PF11932.8 ORX70746.1 - 0.00092 18.6 7.7 0.00092 18.6 7.7 7.2 1 1 6 7 7 7 2 Protein of unknown function (DUF3450) CALCOCO1 PF07888.11 ORX70746.1 - 0.0022 17.0 28.2 0.0022 17.0 28.2 3.2 1 1 2 3 3 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like KASH_CCD PF14662.6 ORX70746.1 - 0.0026 17.6 88.2 0.0064 16.4 11.7 5.0 1 1 3 4 4 4 3 Coiled-coil region of CCDC155 or KASH DUF4201 PF13870.6 ORX70746.1 - 0.0073 16.1 7.7 0.0073 16.1 7.7 6.4 1 1 3 5 5 4 2 Domain of unknown function (DUF4201) Fez1 PF06818.15 ORX70746.1 - 0.015 15.8 16.1 0.015 15.8 16.1 4.7 1 1 3 5 5 5 0 Fez1 DUF5082 PF16888.5 ORX70746.1 - 0.017 15.4 10.5 0.017 15.4 10.5 6.9 2 2 2 5 5 5 0 Domain of unknown function (DUF5082) Myosin_tail_1 PF01576.19 ORX70746.1 - 0.11 10.3 99.5 0.11 10.2 48.2 3.2 1 1 1 3 3 3 0 Myosin tail DUF1664 PF07889.12 ORX70746.1 - 0.33 11.0 55.7 0.69 10.0 1.8 7.7 2 2 8 10 10 10 0 Protein of unknown function (DUF1664) GAS PF13851.6 ORX70746.1 - 0.4 10.0 85.8 3.2 7.1 11.4 5.4 2 2 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 ORX70746.1 - 0.77 7.2 113.4 0.43 8.0 19.6 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) IFT57 PF10498.9 ORX70746.1 - 1.1 8.1 71.0 0.25 10.3 7.1 5.2 1 1 2 5 5 5 0 Intra-flagellar transport protein 57 ATG16 PF08614.11 ORX70746.1 - 5.6 7.1 124.5 0.26 11.5 22.7 6.8 1 1 4 5 5 4 0 Autophagy protein 16 (ATG16) CMV_1a PF12467.8 ORX70747.1 - 0.036 14.4 0.7 0.036 14.4 0.7 1.6 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family TIL PF01826.17 ORX70747.1 - 2.2 8.6 11.7 1.9 8.8 0.5 2.3 1 1 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain DUF515 PF04415.12 ORX70747.1 - 7.5 4.8 12.3 11 4.3 12.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Transferase PF02458.15 ORX70748.1 - 7.9e-19 67.6 0.0 8.5e-13 47.7 0.0 2.1 2 0 0 2 2 2 2 Transferase family p450 PF00067.22 ORX70749.1 - 3.7e-61 207.3 0.0 4.5e-61 207.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 WH2 PF02205.20 ORX70750.1 - 0.0045 16.8 0.0 0.0081 16.0 0.0 1.5 1 0 0 1 1 1 1 WH2 motif Syntaxin PF00804.25 ORX70751.1 - 2.1e-23 83.0 10.5 2.1e-23 83.0 10.5 1.8 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 ORX70751.1 - 6.9e-12 45.2 0.5 6.9e-12 45.2 0.5 2.0 2 0 0 2 2 1 1 SNARE domain Spectrin PF00435.21 ORX70751.1 - 0.0022 18.4 7.3 0.052 14.0 0.0 3.1 2 1 0 3 3 3 1 Spectrin repeat Nup54 PF13874.6 ORX70751.1 - 0.0055 16.8 12.7 0.24 11.5 5.5 2.5 2 0 0 2 2 2 2 Nucleoporin complex subunit 54 Syntaxin_2 PF14523.6 ORX70751.1 - 0.0068 16.8 7.7 0.13 12.6 0.6 2.4 2 0 0 2 2 2 2 Syntaxin-like protein SKA1 PF07160.12 ORX70751.1 - 0.021 14.7 3.6 0.021 14.7 3.6 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 HTH_40 PF14493.6 ORX70751.1 - 0.026 15.0 3.0 0.79 10.2 0.3 3.0 3 1 0 3 3 2 0 Helix-turn-helix domain Synaptobrevin PF00957.21 ORX70751.1 - 0.034 13.9 0.8 0.034 13.9 0.8 2.2 2 0 0 2 2 2 0 Synaptobrevin DUF2207 PF09972.9 ORX70751.1 - 0.1 11.4 1.0 0.13 11.0 0.5 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DotU PF09850.9 ORX70751.1 - 0.17 11.6 4.9 0.5 10.0 0.0 2.7 2 1 1 3 3 3 0 Type VI secretion system protein DotU MCPsignal PF00015.21 ORX70751.1 - 0.39 10.5 9.5 0.11 12.3 3.2 2.5 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SKG6 PF08693.10 ORX70751.1 - 0.79 9.2 9.3 0.18 11.3 3.6 2.3 2 1 0 2 2 2 0 Transmembrane alpha-helix domain LPP PF04728.13 ORX70751.1 - 1.5 9.3 9.3 31 5.0 3.0 3.7 3 1 0 3 3 3 0 Lipoprotein leucine-zipper P4Ha_N PF08336.11 ORX70751.1 - 1.6 8.7 9.3 0.33 11.0 0.6 2.6 2 1 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FliJ PF02050.16 ORX70751.1 - 3.6 7.8 21.5 0.041 14.1 6.5 3.3 1 1 0 2 2 2 0 Flagellar FliJ protein Alanine_zipper PF11839.8 ORX70751.1 - 4 7.9 11.7 2.2 8.7 1.5 3.3 3 1 1 4 4 3 0 Alanine-zipper, major outer membrane lipoprotein BAF1_ABF1 PF04684.13 ORX70751.1 - 4.4 6.2 13.6 5.3 6.0 13.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FIVAR PF07554.13 ORX70751.1 - 6.2 7.7 9.0 13 6.6 0.9 3.2 3 0 0 3 3 3 0 FIVAR domain TolA_bind_tri PF16331.5 ORX70751.1 - 6.7 6.9 13.3 5.1 7.2 3.6 2.9 3 0 0 3 3 2 0 TolA binding protein trimerisation Z1 PF10593.9 ORX70751.1 - 8.3 5.8 11.3 0.82 9.1 3.1 2.7 1 1 3 4 4 4 0 Z1 domain Glyco_transf_15 PF01793.16 ORX70753.1 - 1.8e-99 333.1 17.3 4.4e-77 259.5 10.6 2.0 1 1 1 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase KA1 PF02149.19 ORX70754.1 - 4.2e-18 64.9 0.3 7.1e-18 64.1 0.3 1.3 1 0 0 1 1 1 1 Kinase associated domain 1 CBM_19 PF03427.13 ORX70755.1 - 0.033 14.2 2.4 0.033 14.2 2.4 1.8 2 1 0 2 2 2 0 Carbohydrate binding domain (family 19) Pkinase PF00069.25 ORX70759.1 - 9.8e-54 182.5 0.0 2.5e-48 164.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70759.1 - 1.6e-28 99.7 0.0 1.5e-27 96.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ORX70759.1 - 2.4e-06 27.0 0.3 4.3e-06 26.2 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX70759.1 - 6.6e-05 22.0 0.1 0.0001 21.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX70759.1 - 0.0012 18.9 0.6 0.0039 17.2 0.6 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX70759.1 - 0.044 13.1 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 ORX70759.1 - 0.057 13.0 0.1 0.088 12.4 0.1 1.2 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 ORX70759.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 ORX70759.1 - 0.16 11.5 0.6 0.35 10.4 0.5 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 ORX70759.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Pkinase_fungal PF17667.1 ORX70759.1 - 0.21 10.3 0.0 0.34 9.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Glyco_transf_15 PF01793.16 ORX70760.1 - 4.7e-123 410.6 10.8 6e-123 410.2 10.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF382 PF04037.13 ORX70760.1 - 0.036 14.2 0.0 3.5 7.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF382) TcpF PF06340.11 ORX70761.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F CPSase_L_D2 PF02786.17 ORX70764.1 - 4.7e-81 271.3 0.0 8.7e-81 270.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 ORX70764.1 - 6.7e-68 228.3 0.0 1e-67 227.7 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 ORX70764.1 - 4.4e-40 136.7 0.1 9.1e-40 135.6 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain HMGL-like PF00682.19 ORX70764.1 - 1.2e-29 103.7 0.4 2.6e-29 102.6 0.1 1.7 2 0 0 2 2 2 1 HMGL-like Biotin_carb_C PF02785.19 ORX70764.1 - 4.3e-29 100.8 0.0 1.2e-28 99.4 0.0 1.8 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ORX70764.1 - 9.7e-17 60.6 1.8 2.4e-16 59.3 1.8 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX70764.1 - 2.7e-10 40.1 0.0 5.2e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX70764.1 - 6.8e-07 29.0 0.0 1.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ORX70764.1 - 7.2e-06 26.1 0.0 1.8e-05 24.9 0.0 1.7 2 0 0 2 2 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ORX70764.1 - 0.00025 20.8 2.0 0.019 14.8 0.5 2.7 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 ORX70764.1 - 0.0014 17.9 0.1 0.013 14.8 0.1 2.2 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_4 PF13535.6 ORX70764.1 - 0.0016 18.0 0.0 0.013 15.1 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ORX70764.1 - 0.002 17.9 0.0 0.005 16.6 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HlyD_3 PF13437.6 ORX70764.1 - 0.0031 18.2 0.8 5.9 7.6 0.1 3.5 3 0 0 3 3 3 1 HlyD family secretion protein RimK PF08443.11 ORX70764.1 - 0.0075 15.9 0.0 0.038 13.6 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 ORX70764.1 - 0.014 14.7 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp NQRA PF05896.11 ORX70764.1 - 0.029 13.8 0.4 0.053 12.9 0.4 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) RnfC_N PF13375.6 ORX70764.1 - 0.035 14.1 0.3 0.21 11.6 0.3 2.1 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain ATPgrasp_Ter PF15632.6 ORX70764.1 - 0.073 12.8 0.1 0.53 10.0 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon PRP4 PF08799.11 ORX70764.1 - 0.099 12.2 0.3 0.25 11.0 0.3 1.7 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like DnaJ_C PF01556.18 ORX70765.1 - 1.4e-32 112.8 0.0 2e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX70765.1 - 5e-26 90.6 1.8 5e-26 90.6 1.8 2.0 3 0 0 3 3 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX70765.1 - 5.5e-15 55.5 14.8 1.1e-14 54.6 14.8 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ORX70765.1 - 3.3e-06 27.0 9.8 0.00082 19.3 1.0 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ORX70765.1 - 0.00013 22.0 5.2 0.25 11.4 2.0 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ORX70765.1 - 0.022 14.8 8.1 0.04 13.9 8.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.5 ORX70765.1 - 0.068 13.3 0.9 0.16 12.1 0.9 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 TackOD1 PF18551.1 ORX70765.1 - 0.094 12.4 7.6 0.064 12.9 1.1 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Ogr_Delta PF04606.12 ORX70765.1 - 0.33 11.0 4.6 0.78 9.8 0.2 2.7 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Lar_restr_allev PF14354.6 ORX70765.1 - 2.3 8.6 10.5 6.6 7.2 0.3 3.3 2 1 1 3 3 3 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 ORX70765.1 - 4.1 7.6 18.3 10 6.4 1.5 4.3 2 2 2 4 4 4 0 Zinc ribbon domain DUF35_N PF12172.8 ORX70765.1 - 10 6.1 9.0 4.1 7.4 0.3 3.5 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) FA_desaturase PF00487.24 ORX70766.1 - 1.5e-32 113.5 12.7 1.5e-32 113.5 12.7 1.8 1 1 1 2 2 2 2 Fatty acid desaturase Cyt-b5 PF00173.28 ORX70766.1 - 1.5e-09 37.8 0.0 3.2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NDK PF00334.19 ORX70768.1 - 5.6e-38 130.0 0.0 6.2e-38 129.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PQ-loop PF04193.14 ORX70769.1 - 1.2e-22 79.4 13.8 5.5e-12 45.3 3.3 3.1 2 1 0 2 2 2 2 PQ loop repeat Secretin_N_2 PF07655.13 ORX70770.1 - 5.8 7.5 12.7 17 6.0 12.7 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Na_H_Exchanger PF00999.21 ORX70771.1 - 1.5e-64 218.2 35.5 1.9e-64 217.9 35.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SPA PF08616.10 ORX70772.1 - 1.4e-05 25.0 0.0 2.6e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis DENN PF02141.21 ORX70772.1 - 0.011 15.7 0.0 0.059 13.3 0.0 2.0 1 1 0 1 1 1 0 DENN (AEX-3) domain MutS_V PF00488.21 ORX70774.1 - 1.2e-66 224.4 0.0 3.2e-66 223.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 ORX70774.1 - 6.5e-30 103.7 0.7 2.1e-29 102.1 0.2 2.0 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 ORX70774.1 - 3.2e-11 43.4 0.1 7.9e-11 42.2 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_III PF05192.18 ORX70774.1 - 8.7e-08 32.6 0.0 2.4e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 MutS domain III AAA_29 PF13555.6 ORX70774.1 - 0.15 11.8 0.2 0.62 9.9 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF2897 PF11446.8 ORX70775.1 - 0.011 15.6 4.1 0.016 15.1 1.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2897) DUF866 PF05907.13 ORX70777.1 - 3.3e-62 209.0 0.2 3.7e-62 208.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Rubredoxin PF00301.20 ORX70777.1 - 0.48 10.5 0.0 0.48 10.5 0.0 3.0 4 0 0 4 4 4 0 Rubredoxin zf-BED PF02892.15 ORX70777.1 - 2.4 8.3 5.9 9.8 6.3 0.3 2.4 1 1 0 2 2 2 0 BED zinc finger Aminotran_3 PF00202.21 ORX70778.1 - 3.7e-93 312.4 0.0 2.8e-92 309.5 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-III MMR_HSR1 PF01926.23 ORX70779.1 - 5e-17 62.0 0.1 4.7e-13 49.2 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX70779.1 - 2.6e-08 33.9 1.0 0.00022 21.2 0.2 2.5 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX70779.1 - 1.7e-07 30.9 0.1 2.8e-05 23.7 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ORX70779.1 - 0.00045 19.8 0.1 0.011 15.3 0.0 2.7 1 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX70779.1 - 0.004 17.2 5.6 0.083 12.9 0.2 3.4 2 2 1 3 3 3 1 Dynamin family GN3L_Grn1 PF08701.11 ORX70779.1 - 0.047 13.8 6.0 0.091 12.9 6.0 1.5 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase PduV-EutP PF10662.9 ORX70779.1 - 0.047 13.4 0.0 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 ORX70779.1 - 0.16 12.2 0.4 14 5.9 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 ORX70779.1 - 2.2 7.2 5.7 0.78 8.7 0.1 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Nup84_Nup100 PF04121.13 ORX70781.1 - 1.8e-115 386.8 2.8 8.7e-114 381.2 2.8 3.3 1 1 0 1 1 1 1 Nuclear pore protein 84 / 107 Tim17 PF02466.19 ORX70782.1 - 5.6e-10 39.6 11.2 1e-09 38.7 11.2 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family RPAP2_Rtr1 PF04181.13 ORX70783.1 - 2.6e-05 24.4 0.5 2.6e-05 24.4 0.5 1.8 2 0 0 2 2 2 1 Rtr1/RPAP2 family SOAR PF16533.5 ORX70783.1 - 0.054 13.5 1.8 0.14 12.2 1.8 1.7 1 0 0 1 1 1 0 STIM1 Orai1-activating region TIP41 PF04176.13 ORX70784.1 - 9.7e-41 139.1 0.0 1.7e-40 138.3 0.0 1.4 1 1 0 1 1 1 1 TIP41-like family OST3_OST6 PF04756.13 ORX70785.1 - 5.5e-53 180.2 0.0 9.9e-53 179.4 0.0 1.4 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 ORX70785.1 - 2.3e-07 30.7 0.0 3.7e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Homeodomain PF00046.29 ORX70786.1 - 2.9e-18 65.5 2.6 4.7e-18 64.8 2.6 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX70786.1 - 0.062 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain HEAT PF02985.22 ORX70788.1 - 8.7e-14 50.5 9.7 0.002 18.2 0.0 9.7 11 0 0 11 11 10 3 HEAT repeat HEAT_EZ PF13513.6 ORX70788.1 - 1.1e-13 51.3 0.1 0.014 15.9 0.4 7.4 4 1 2 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 ORX70788.1 - 1.9e-10 41.0 0.1 1.6 9.2 0.0 7.9 4 3 2 7 7 7 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX70788.1 - 4.9e-09 36.7 0.1 1.4 9.6 0.0 6.6 5 1 2 7 7 7 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 ORX70788.1 - 8.7e-08 32.0 1.5 1.2e-06 28.4 0.6 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain CLASP_N PF12348.8 ORX70788.1 - 1.8e-07 30.9 0.0 0.73 9.3 0.0 6.0 6 0 0 6 6 6 2 CLASP N terminal Cnd1 PF12717.7 ORX70788.1 - 3.5e-06 27.1 0.4 0.68 10.0 0.0 5.4 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 ERAP1_C PF11838.8 ORX70788.1 - 0.017 14.7 0.2 4.2 6.8 0.0 2.8 2 0 0 2 2 2 0 ERAP1-like C-terminal domain UNC45-central PF11701.8 ORX70788.1 - 0.021 14.8 0.6 0.35 10.8 0.0 3.4 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central Tti2 PF10521.9 ORX70788.1 - 0.022 14.3 0.1 24 4.3 0.0 4.1 4 0 0 4 4 4 0 Tti2 family BP28CT PF08146.12 ORX70788.1 - 0.031 14.1 0.1 6.2 6.7 0.0 4.6 6 1 0 6 6 6 0 BP28CT (NUC211) domain TPR_1 PF00515.28 ORX70789.1 - 8.7e-43 142.5 17.1 2.5e-05 23.9 0.2 11.0 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ORX70789.1 - 2.3e-37 124.1 19.6 7.5e-05 22.5 0.4 10.7 9 1 1 10 10 10 9 Tetratricopeptide repeat TPR_11 PF13414.6 ORX70789.1 - 1.9e-24 85.1 17.9 5.9e-05 22.7 0.0 10.0 4 3 6 10 10 10 6 TPR repeat TPR_8 PF13181.6 ORX70789.1 - 1.9e-22 77.5 23.9 0.0076 16.4 0.1 10.9 12 0 0 12 12 10 4 Tetratricopeptide repeat TPR_17 PF13431.6 ORX70789.1 - 3.1e-22 77.3 7.1 0.0015 18.8 0.0 8.7 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX70789.1 - 6.4e-18 65.1 22.0 5e-05 23.9 0.0 8.1 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 ORX70789.1 - 4e-17 62.5 34.2 1.4e-05 25.5 0.1 7.7 7 2 2 9 9 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX70789.1 - 4.3e-17 62.2 23.7 0.0014 18.8 0.4 8.8 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX70789.1 - 7.7e-16 57.4 27.7 0.0059 17.3 0.3 10.7 4 3 7 11 11 11 5 Tetratricopeptide repeat TPR_9 PF13371.6 ORX70789.1 - 3.2e-12 46.4 8.3 0.0027 17.8 0.2 5.8 2 1 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX70789.1 - 2e-10 39.9 14.7 0.35 11.0 0.1 8.8 9 1 1 10 10 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX70789.1 - 2.2e-07 31.0 10.7 0.013 15.7 0.0 5.2 3 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ORX70789.1 - 2.2e-06 27.1 15.6 0.02 14.1 1.8 4.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX70789.1 - 2.3e-06 27.9 22.8 0.58 10.9 0.0 9.4 9 0 0 9 9 9 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX70789.1 - 2.9e-05 23.2 22.8 0.00092 18.2 0.0 4.7 3 1 2 5 5 5 2 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 ORX70789.1 - 0.00079 19.8 4.6 2.3 9.1 0.2 5.7 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 ORX70789.1 - 0.003 17.3 23.3 0.027 14.2 0.0 4.9 2 1 1 4 4 4 1 Tetratricopeptide repeat-like domain SHNi-TPR PF10516.9 ORX70789.1 - 0.0069 15.8 5.1 0.32 10.5 0.0 4.6 5 0 0 5 5 5 1 SHNi-TPR DUF4810 PF16068.5 ORX70789.1 - 0.021 15.4 0.4 16 6.2 0.0 4.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) BTAD PF03704.17 ORX70789.1 - 0.027 14.9 0.0 0.027 14.9 0.0 4.5 4 1 0 5 5 4 0 Bacterial transcriptional activator domain ArsR PF09824.9 ORX70789.1 - 0.032 13.8 0.0 4.4 6.9 0.0 3.1 3 0 0 3 3 3 0 ArsR transcriptional regulator TRF PF08558.10 ORX70789.1 - 0.049 13.2 0.5 0.14 11.7 0.1 1.9 2 0 0 2 2 2 0 Telomere repeat binding factor (TRF) RPN7 PF10602.9 ORX70789.1 - 0.085 12.6 7.2 1.6 8.4 0.1 4.3 3 1 1 4 4 4 0 26S proteasome subunit RPN7 AMNp_N PF10423.9 ORX70789.1 - 0.11 12.1 0.0 0.36 10.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus TPR_10 PF13374.6 ORX70789.1 - 2 8.4 18.2 9 6.3 0.2 7.6 9 1 1 10 10 9 0 Tetratricopeptide repeat Sec1 PF00995.23 ORX70790.1 - 1.7e-103 347.8 0.1 1.2e-102 345.0 0.1 2.0 1 1 0 1 1 1 1 Sec1 family EcoEI_R_C PF08463.10 ORX70790.1 - 0.041 14.0 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 EcoEI R protein C-terminal DnaJ PF00226.31 ORX70791.1 - 8.1e-16 57.9 0.1 8.1e-16 57.9 0.1 2.4 2 1 1 3 3 3 1 DnaJ domain RAC_head PF16717.5 ORX70791.1 - 1.8e-08 35.3 0.3 1.8e-08 35.3 0.3 3.2 2 1 2 4 4 4 1 Ribosome-associated complex head domain LMBR1 PF04791.16 ORX70791.1 - 0.38 9.6 2.4 0.42 9.5 2.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein OATP PF03137.20 ORX70791.1 - 0.92 7.7 2.9 1.4 7.1 2.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2514 PF10721.9 ORX70791.1 - 1.6 8.8 25.0 0.2 11.7 18.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Hid1 PF12722.7 ORX70791.1 - 1.9 6.5 7.1 3.3 5.7 7.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TrmO_C PF18389.1 ORX70791.1 - 2.1 8.5 6.8 0.48 10.6 0.2 2.7 3 0 0 3 3 3 0 TrmO C-terminal domain MFS_1 PF07690.16 ORX70792.1 - 7.4e-10 38.3 25.5 3.3e-09 36.1 22.1 2.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Transgly_assoc PF04226.13 ORX70792.1 - 0.068 13.4 13.4 0.43 10.9 0.1 3.9 3 0 0 3 3 3 0 Transglycosylase associated protein DUF4131 PF13567.6 ORX70792.1 - 2.3 7.9 8.1 0.18 11.4 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Cation_ATPase_C PF00689.21 ORX70792.1 - 7.2 6.3 18.4 2.1 8.0 7.0 3.1 2 2 0 2 2 2 0 Cation transporting ATPase, C-terminus Oxysterol_BP PF01237.18 ORX70793.1 - 9e-59 199.2 18.0 2.8e-55 187.7 0.0 2.9 4 0 0 4 4 4 2 Oxysterol-binding protein PH_8 PF15409.6 ORX70793.1 - 2.7e-17 62.8 0.6 6.1e-17 61.7 0.6 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX70793.1 - 1e-05 26.0 0.4 5.2e-05 23.7 0.1 2.4 2 0 0 2 2 2 1 PH domain GOLD_2 PF13897.6 ORX70793.1 - 0.00065 20.2 2.2 0.0031 18.0 0.0 2.7 3 0 0 3 3 3 1 Golgi-dynamics membrane-trafficking Peptidase_S21 PF00716.17 ORX70794.1 - 0.15 11.7 6.1 0.17 11.5 6.1 1.0 1 0 0 1 1 1 0 Assemblin (Peptidase family S21) DUF2076 PF09849.9 ORX70794.1 - 0.28 11.2 6.9 0.32 11.0 6.9 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 ORX70795.1 - 2.5e-06 27.5 5.7 3.9e-06 26.9 5.7 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 ORX70795.1 - 0.00053 19.9 1.5 0.00083 19.3 1.5 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, MTCP1 PF08991.10 ORX70795.1 - 0.0031 17.7 2.8 0.0046 17.1 2.8 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type DUF3128 PF11326.8 ORX70795.1 - 0.53 10.7 4.7 6.3 7.2 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) tRNA-synt_1b PF00579.25 ORX70796.1 - 6.7e-25 88.0 0.0 1.3e-24 87.0 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) VbhA PF18495.1 ORX70796.1 - 0.018 14.9 0.6 0.054 13.4 0.2 2.0 2 0 0 2 2 2 0 Antitoxin VbhA Paf1 PF03985.13 ORX70797.1 - 9.4e-51 173.1 13.5 3.5e-27 95.5 9.5 2.0 1 1 1 2 2 2 2 Paf1 Bac_globin PF01152.21 ORX70797.1 - 0.083 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial-like globin zf-HC5HC2H_2 PF13832.6 ORX70798.1 - 2.2e-11 43.9 7.1 3.3e-10 40.1 1.2 2.4 2 0 0 2 2 2 2 PHD-zinc-finger like domain PHD_2 PF13831.6 ORX70798.1 - 3.9e-09 35.9 3.4 3.9e-09 35.9 3.4 2.2 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 ORX70798.1 - 1.8e-08 34.5 8.4 6e-06 26.4 3.1 2.6 2 0 0 2 2 2 2 PHD-like zinc-binding domain PHD PF00628.29 ORX70798.1 - 1.2e-06 28.3 6.4 1.2e-06 28.3 6.4 2.6 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 ORX70798.1 - 0.012 15.3 2.4 0.035 13.7 2.4 1.9 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DUF3960 PF13142.6 ORX70798.1 - 0.21 11.7 0.0 0.42 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3960) Cytochrom_B562 PF07361.11 ORX70798.1 - 1.6 9.4 5.5 0.83 10.3 1.2 2.5 2 0 0 2 2 2 0 Cytochrome b562 FANCL_C PF11793.8 ORX70798.1 - 1.8 8.8 17.6 0.13 12.5 3.7 2.5 2 0 0 2 2 2 0 FANCL C-terminal domain Ldh_1_C PF02866.18 ORX70801.1 - 1.4e-43 148.8 0.0 2e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ORX70801.1 - 3.6e-39 134.1 1.0 5.4e-39 133.5 1.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ras PF00071.22 ORX70802.1 - 6.6e-55 185.1 0.2 8.5e-55 184.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX70802.1 - 5.6e-31 107.3 0.1 1.1e-30 106.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX70802.1 - 6e-09 35.6 0.0 1.1e-08 34.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX70802.1 - 4.9e-07 29.8 0.0 8.2e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX70802.1 - 0.0022 18.4 0.2 0.0046 17.3 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX70802.1 - 0.0062 16.5 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Gtr1_RagA PF04670.12 ORX70802.1 - 0.0069 15.8 0.1 0.016 14.5 0.0 1.6 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ORX70802.1 - 0.011 16.0 0.1 0.025 14.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX70802.1 - 0.014 15.9 0.2 0.021 15.3 0.2 1.6 1 1 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 ORX70802.1 - 0.015 14.8 0.3 0.37 10.3 0.0 2.5 1 1 2 3 3 3 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX70802.1 - 0.016 14.6 0.1 0.082 12.3 0.0 1.9 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 ORX70802.1 - 0.017 15.3 0.1 0.85 9.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX70802.1 - 0.019 14.7 0.1 0.037 13.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ORX70802.1 - 0.029 14.2 0.9 0.055 13.3 0.6 1.7 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system KAP_NTPase PF07693.14 ORX70802.1 - 0.048 12.9 0.1 0.097 11.9 0.1 1.5 1 1 0 1 1 1 0 KAP family P-loop domain AAA_7 PF12775.7 ORX70802.1 - 0.057 12.9 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region FAD-SLDH PF12318.8 ORX70802.1 - 0.073 13.1 0.1 0.2 11.7 0.1 1.8 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase TniB PF05621.11 ORX70802.1 - 0.075 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_5 PF07728.14 ORX70802.1 - 0.086 12.8 0.1 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MCM PF00493.23 ORX70802.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain FeoB_N PF02421.18 ORX70802.1 - 0.1 12.1 0.0 0.23 11.0 0.0 1.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Pkinase PF00069.25 ORX70803.1 - 1.1e-65 221.6 0.0 1.3e-65 221.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70803.1 - 1.9e-47 161.8 0.0 2.4e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX70803.1 - 5e-07 29.3 0.0 1.4e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX70803.1 - 8.5e-05 21.5 0.0 0.00012 21.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX70803.1 - 0.014 15.3 0.1 0.54 10.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX70803.1 - 0.024 13.6 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Ras PF00071.22 ORX70804.1 - 5.4e-57 191.9 0.1 6.2e-57 191.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX70804.1 - 1.8e-20 73.4 0.0 3.2e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX70804.1 - 5.8e-07 29.1 0.0 7.2e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX70804.1 - 1.8e-05 24.4 0.4 0.00012 21.7 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX70804.1 - 0.00024 21.0 0.0 0.067 13.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX70804.1 - 0.00061 19.3 0.1 0.0027 17.3 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ORX70804.1 - 0.0073 16.4 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 ORX70804.1 - 0.045 13.8 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_25 PF13481.6 ORX70804.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX70804.1 - 0.16 12.4 0.1 0.22 11.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 ORX70804.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Myosin_head PF00063.21 ORX70805.1 - 1.1e-194 648.5 0.0 3.2e-194 647.0 0.0 1.8 1 1 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 ORX70805.1 - 1.3e-08 33.9 9.8 0.0089 15.7 0.2 4.5 4 0 0 4 4 4 3 IQ calmodulin-binding motif AAA_16 PF13191.6 ORX70805.1 - 0.00032 21.1 4.9 0.001 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX70805.1 - 0.00056 20.2 1.8 0.00067 19.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ORX70805.1 - 0.018 15.4 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ORX70805.1 - 0.02 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX70805.1 - 0.021 14.8 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 ORX70805.1 - 0.059 13.7 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX70805.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 ORX70805.1 - 0.072 13.6 1.4 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 ABC transporter G-alpha PF00503.20 ORX70805.1 - 0.11 11.7 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit ATPase_2 PF01637.18 ORX70805.1 - 0.25 11.2 3.3 0.39 10.6 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ERM PF00769.19 ORX70805.1 - 0.3 10.9 17.9 0.59 9.9 17.9 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Myosin_N PF02736.19 ORX70805.1 - 0.32 10.9 3.4 0.14 12.0 0.6 1.9 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain AAA_11 PF13086.6 ORX70805.1 - 1.4 8.6 7.9 33 4.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ORX70805.1 - 2.5 8.6 6.8 27 5.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Peptidase_C15 PF01470.17 ORX70806.1 - 0.22 11.7 0.0 0.32 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyroglutamyl peptidase HEAT PF02985.22 ORX70807.1 - 4.1e-06 26.6 4.8 0.0036 17.4 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat Pkinase PF00069.25 ORX70807.1 - 8e-06 25.4 0.0 0.00033 20.1 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain WD40 PF00400.32 ORX70807.1 - 0.00017 22.3 0.2 0.52 11.3 0.1 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat HEAT_2 PF13646.6 ORX70807.1 - 0.00098 19.5 1.7 0.077 13.4 0.0 3.6 3 1 1 4 4 4 1 HEAT repeats Suv3_C_1 PF18147.1 ORX70808.1 - 1.5e-11 44.0 0.1 3.5e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 SUV3_C PF12513.8 ORX70808.1 - 2.2e-10 40.3 0.1 7.1e-10 38.7 0.1 1.9 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 ORX70808.1 - 7.7e-05 23.0 0.1 0.0002 21.7 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX70808.1 - 0.087 12.6 0.0 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF5466 PF17554.2 ORX70808.1 - 0.11 12.8 0.1 0.34 11.1 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5466) HTH_7 PF02796.15 ORX70809.1 - 0.14 12.2 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Sde2_N_Ubi PF13019.6 ORX70812.1 - 1.6e-24 86.6 5.7 1.6e-24 86.6 5.7 2.0 2 1 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain Ribosomal_L20 PF00453.18 ORX70812.1 - 0.075 13.1 4.1 0.11 12.6 4.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L20 Ntox15 PF15604.6 ORX70812.1 - 0.2 11.8 4.0 0.21 11.7 3.0 1.5 1 1 0 1 1 1 0 Novel toxin 15 Nop25 PF09805.9 ORX70812.1 - 4 7.9 18.0 7.3 7.1 18.0 1.4 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) Aldedh PF00171.22 ORX70813.1 - 1.2e-142 475.7 2.6 9.5e-113 377.1 0.7 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family WD40 PF00400.32 ORX70814.1 - 1.5e-39 133.3 27.0 1.3e-07 32.1 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX70814.1 - 1.5e-12 47.7 2.5 0.6 10.4 0.0 6.5 2 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX70814.1 - 0.00037 20.4 0.6 0.24 11.3 0.1 3.9 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 ORX70814.1 - 0.022 12.8 0.2 0.03 12.3 0.2 1.2 1 0 0 1 1 1 0 IKI3 family SH3_9 PF14604.6 ORX70814.1 - 0.033 14.1 0.2 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 Variant SH3 domain Ge1_WD40 PF16529.5 ORX70814.1 - 0.034 13.1 3.1 0.5 9.3 0.0 3.4 2 1 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Thiolase_N PF00108.23 ORX70815.1 - 2.4e-62 210.7 1.1 2.9e-37 128.4 0.0 2.2 1 1 1 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX70815.1 - 2.3e-12 46.6 5.2 6.3e-08 32.3 0.1 2.8 2 1 1 3 3 3 2 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX70815.1 - 0.012 15.2 0.1 0.024 14.2 0.1 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 ORX70816.1 - 8.9e-81 271.1 0.5 1.5e-80 270.3 0.5 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX70816.1 - 1.9e-46 156.7 0.3 3.8e-46 155.7 0.3 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX70816.1 - 0.017 14.7 2.4 0.073 12.6 0.4 2.3 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain F-box-like PF12937.7 ORX70818.1 - 0.013 15.4 0.3 0.018 14.9 0.3 1.3 1 0 0 1 1 1 0 F-box-like DnaJ_C PF01556.18 ORX70819.1 - 8.7e-40 136.2 0.0 1.1e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX70819.1 - 4e-25 87.7 7.4 6.3e-25 87.1 7.4 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX70819.1 - 4.9e-08 33.2 8.5 9.2e-08 32.3 8.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrome_C7 PF14522.6 ORX70819.1 - 0.059 13.4 1.9 0.12 12.4 1.9 1.5 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c Anti-TRAP PF15777.5 ORX70819.1 - 0.087 12.8 8.1 1.5 8.9 2.6 2.6 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ORX70819.1 - 1.7 8.7 3.6 5.8 7.0 3.6 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA IF-2B PF01008.17 ORX70820.1 - 1.7e-42 145.6 0.3 4.1e-21 75.4 0.0 2.1 2 0 0 2 2 2 2 Initiation factor 2 subunit family VRR_NUC PF08774.11 ORX70821.1 - 1.7e-16 60.2 0.0 3.8e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 VRR-NUC domain Sld7_C PF18596.1 ORX70821.1 - 0.16 12.2 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Sld7 C-terminal domain Ion_trans PF00520.31 ORX70822.1 - 2.5e-28 98.9 14.2 3.3e-28 98.6 14.2 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ORX70822.1 - 5.9e-10 39.0 11.3 5.9e-10 39.0 11.3 2.0 2 1 0 2 2 2 1 Ion channel DUF4383 PF14325.6 ORX70822.1 - 0.43 10.9 4.1 4.2 7.7 2.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4383) PCI PF01399.27 ORX70823.1 - 1.8e-11 44.5 0.2 2.6e-11 44.0 0.2 1.3 1 0 0 1 1 1 1 PCI domain Herpes_UL31 PF02718.14 ORX70823.1 - 0.046 12.7 0.2 0.071 12.1 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL31-like protein CRAL_TRIO PF00650.20 ORX70824.1 - 1.1e-24 86.9 0.1 1.8e-24 86.3 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ORX70824.1 - 1.1e-05 25.7 0.0 1.9e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX70824.1 - 0.001 19.2 0.0 0.0032 17.6 0.0 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF2470 PF10615.9 ORX70825.1 - 8.9e-05 23.0 0.0 0.00016 22.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 ORX70825.1 - 0.0091 16.3 1.3 0.016 15.5 1.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) Pyrophosphatase PF00719.19 ORX70826.1 - 2.3e-44 151.1 0.0 1e-43 148.9 0.0 1.8 1 1 0 1 1 1 1 Inorganic pyrophosphatase FYVE PF01363.21 ORX70828.1 - 1.5e-07 31.4 7.7 1.5e-07 31.4 7.7 2.8 2 1 0 2 2 2 1 FYVE zinc finger Snf7 PF03357.21 ORX70829.1 - 7.1e-24 84.3 21.1 7.1e-24 84.3 21.1 1.5 1 1 0 1 1 1 1 Snf7 Med26 PF08711.11 ORX70829.1 - 0.0079 16.2 5.1 0.064 13.3 0.3 3.0 3 0 0 3 3 3 1 TFIIS helical bundle-like domain CheX PF13690.6 ORX70829.1 - 0.019 15.1 3.8 0.02 15.1 2.0 1.9 1 1 0 1 1 1 0 Chemotaxis phosphatase CheX Mo25 PF08569.11 ORX70829.1 - 0.44 9.9 9.7 0.75 9.1 8.1 1.7 1 1 1 2 2 2 0 Mo25-like zf-ZPR1 PF03367.13 ORX70829.1 - 2.9 7.7 8.1 0.57 10.0 2.7 2.4 1 1 1 2 2 2 0 ZPR1 zinc-finger domain EAL PF00563.20 ORX70830.1 - 0.043 13.3 0.1 0.097 12.2 0.1 1.6 1 0 0 1 1 1 0 EAL domain DUF573 PF04504.14 ORX70832.1 - 0.81 10.4 6.9 8.2 7.2 6.9 2.1 1 1 0 1 1 1 0 Protein of unknown function, DUF573 BCDHK_Adom3 PF10436.9 ORX70833.1 - 3.1e-62 209.2 0.2 4.9e-62 208.5 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX70833.1 - 6.2e-15 55.7 0.0 6.5e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX70833.1 - 0.00025 20.9 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Med18 PF09637.10 ORX70834.1 - 2.9e-11 43.7 0.0 1.5e-09 38.1 0.0 2.0 2 0 0 2 2 2 2 Med18 protein Lysine_decarbox PF03641.14 ORX70835.1 - 3.8e-40 137.0 0.0 5.1e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 ORX70835.1 - 9.3e-15 54.6 0.0 1.2e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 SLOG cluster4 family Peptidase_S58 PF03576.14 ORX70835.1 - 0.043 13.3 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S58 AAA PF00004.29 ORX70836.1 - 7.9e-39 133.1 0.0 1.4e-38 132.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX70836.1 - 3.4e-09 36.3 0.0 6.7e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX70836.1 - 1.1e-06 28.7 0.1 4e-06 26.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX70836.1 - 1.9e-06 28.4 0.2 0.00028 21.3 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX70836.1 - 2.6e-06 27.7 0.3 0.0065 16.8 0.0 3.1 1 1 2 3 3 3 1 AAA domain AAA_14 PF13173.6 ORX70836.1 - 1e-05 25.6 0.0 2.5e-05 24.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 ORX70836.1 - 4.8e-05 23.1 0.0 0.0001 22.1 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 ORX70836.1 - 5.5e-05 22.7 0.2 0.42 10.0 0.0 3.0 2 1 1 3 3 3 2 Bacterial TniB protein AAA_2 PF07724.14 ORX70836.1 - 0.00012 22.3 0.0 0.0003 21.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ORX70836.1 - 0.00013 22.5 0.0 0.00024 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX70836.1 - 0.00043 20.4 0.0 0.00067 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX70836.1 - 0.00075 19.3 0.0 0.0014 18.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX70836.1 - 0.00086 18.7 0.3 0.0021 17.4 0.2 1.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ORX70836.1 - 0.0011 19.3 0.0 0.0028 18.0 0.0 1.8 1 1 0 1 1 1 1 RNA helicase Rad17 PF03215.15 ORX70836.1 - 0.0023 17.9 0.1 0.0094 15.9 0.0 2.0 1 1 0 2 2 2 1 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 ORX70836.1 - 0.0053 16.9 0.0 0.013 15.6 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ORX70836.1 - 0.0072 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 ORX70836.1 - 0.01 16.1 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ORX70836.1 - 0.011 15.0 0.0 0.046 13.1 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 ORX70836.1 - 0.013 15.0 0.2 0.076 12.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ORX70836.1 - 0.014 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 ORX70836.1 - 0.025 14.5 0.3 0.083 12.8 0.1 1.9 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 ORX70836.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF815 PF05673.13 ORX70836.1 - 0.031 13.4 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Hydin_ADK PF17213.3 ORX70836.1 - 0.039 14.2 0.1 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 ORX70836.1 - 0.039 14.4 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ORX70836.1 - 0.04 13.1 0.1 0.093 11.9 0.0 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 ORX70836.1 - 0.044 13.7 0.0 0.49 10.3 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ORX70836.1 - 0.044 13.3 0.0 0.13 11.8 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ORX70836.1 - 0.07 13.6 0.0 0.14 12.7 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Parvo_NS1 PF01057.17 ORX70836.1 - 0.09 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 ORX70836.1 - 0.1 12.5 0.0 0.34 10.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ORX70836.1 - 0.11 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ORX70836.1 - 0.15 11.8 0.0 0.45 10.2 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 ORX70836.1 - 0.16 11.3 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase DIL PF01843.19 ORX70837.1 - 1.2e-21 76.9 0.8 1.2e-21 76.9 0.8 1.9 2 1 1 3 3 3 1 DIL domain Ank_5 PF13857.6 ORX70837.1 - 8.7e-07 29.1 0.0 2.4e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX70837.1 - 1.1e-06 29.2 0.0 2.8e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX70837.1 - 4.9e-06 26.8 0.0 1.3e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 ORX70837.1 - 3.2e-05 24.4 0.1 0.0013 19.3 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX70837.1 - 0.00039 20.6 0.0 0.0027 18.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Flp_N PF03930.14 ORX70837.1 - 0.034 14.1 0.0 0.19 11.7 0.0 2.2 3 0 0 3 3 3 0 Recombinase Flp protein N-terminus ING PF12998.7 ORX70838.1 - 1.4e-09 38.5 3.4 5.8e-05 23.6 0.1 2.2 1 1 1 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX70838.1 - 1.2e-05 25.1 9.0 1.9e-05 24.5 9.0 1.3 1 0 0 1 1 1 1 PHD-finger HeLo PF14479.6 ORX70838.1 - 0.0056 16.5 0.4 0.0082 16.0 0.4 1.2 1 0 0 1 1 1 1 Prion-inhibition and propagation PHD_2 PF13831.6 ORX70838.1 - 0.041 13.4 4.3 0.096 12.3 4.3 1.6 1 0 0 1 1 1 0 PHD-finger Csm2_III-A PF03750.13 ORX70838.1 - 0.047 14.5 0.2 0.073 13.9 0.2 1.3 1 0 0 1 1 1 0 Csm2 Type III-A Syntaxin PF00804.25 ORX70838.1 - 0.048 13.3 1.0 0.062 13.0 1.0 1.1 1 0 0 1 1 1 0 Syntaxin ABC_transp_aux PF09822.9 ORX70838.1 - 0.093 12.2 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 ABC-type uncharacterized transport system BRE1 PF08647.11 ORX70838.1 - 0.26 11.4 3.9 3.2 7.9 0.4 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase zf-RING_2 PF13639.6 ORX70838.1 - 0.78 10.1 4.0 65 4.0 5.3 2.2 1 1 1 2 2 2 0 Ring finger domain Adaptin_N PF01602.20 ORX70840.1 - 1.9e-102 343.6 0.1 2.6e-102 343.1 0.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ORX70840.1 - 4.7e-15 55.9 0.3 2e-14 53.8 0.3 2.1 1 1 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ORX70840.1 - 0.0076 16.3 1.8 1 9.4 0.3 3.3 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX70840.1 - 0.025 14.9 12.7 3.6 8.0 0.1 5.3 4 2 1 5 5 5 0 HEAT repeats Myb_DNA-binding PF00249.31 ORX70841.1 - 0.0014 18.8 1.1 0.032 14.4 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX70841.1 - 0.0032 17.7 0.4 0.013 15.8 0.1 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.12 ORX70841.1 - 0.094 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF212 PF02681.14 ORX70842.1 - 0.00023 21.3 0.1 0.00035 20.7 0.1 1.4 1 0 0 1 1 1 1 Divergent PAP2 family PAP2 PF01569.21 ORX70842.1 - 0.001 18.8 3.7 0.0047 16.7 3.7 2.0 1 1 0 1 1 1 1 PAP2 superfamily RasGEF PF00617.19 ORX70843.1 - 4.1e-28 98.8 0.0 5.2e-27 95.2 0.0 2.4 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX70843.1 - 2.7e-15 56.5 0.0 6.1e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ntox10 PF15520.6 ORX70843.1 - 0.023 14.6 0.2 0.058 13.3 0.2 1.6 1 0 0 1 1 1 0 Novel toxin 10 Pkinase PF00069.25 ORX70847.1 - 2.9e-37 128.5 0.0 4.1e-37 128.0 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX70847.1 - 2.7e-18 66.2 0.0 1e-17 64.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX70847.1 - 0.00044 19.7 0.0 0.00075 18.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 ORX70847.1 - 0.001 18.7 0.0 0.51 9.9 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX70847.1 - 0.005 16.8 0.3 3.3 7.6 0.2 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX70847.1 - 0.0067 15.8 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TFCD_C PF12612.8 ORX70848.1 - 0.0018 18.2 0.3 0.0059 16.5 0.1 2.0 1 1 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 ORX70849.1 - 0.00088 19.3 4.3 0.047 14.0 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 ORX70849.1 - 0.017 15.5 0.1 0.87 10.0 0.0 2.8 2 0 0 2 2 2 0 HEAT repeats CLASP_N PF12348.8 ORX70849.1 - 0.18 11.4 0.5 34 3.9 0.0 3.4 4 0 0 4 4 4 0 CLASP N terminal Haspin_kinase PF12330.8 ORX70850.1 - 1.9e-39 135.6 0.0 3.5e-39 134.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Dak1 PF02733.17 ORX70852.1 - 2.1e-99 332.4 0.3 3e-99 331.8 0.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ORX70852.1 - 8.3e-42 143.0 5.1 1.5e-41 142.2 5.1 1.4 1 0 0 1 1 1 1 DAK2 domain PH_6 PF15406.6 ORX70853.1 - 0.0028 17.9 0.0 0.009 16.3 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain MMR1 PF08505.10 ORX70853.1 - 7.4 6.8 15.5 0.31 11.3 2.6 3.0 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein zf-CCCH PF00642.24 ORX70854.1 - 5.4e-16 58.1 15.8 1.3e-10 40.9 1.9 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX70854.1 - 5.1e-10 39.1 15.1 4.7e-05 23.3 4.5 2.6 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ORX70854.1 - 1.6e-08 34.1 14.2 2.2e-06 27.3 1.5 3.0 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX70854.1 - 0.0058 17.0 15.1 0.046 14.2 3.3 3.0 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX70854.1 - 0.0074 17.0 5.4 0.22 12.3 0.5 2.8 1 1 1 2 2 2 2 Torus domain BTG PF07742.12 ORX70855.1 - 3.1e-20 72.2 0.0 3.5e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 BTG family CoA_transf_3 PF02515.17 ORX70856.1 - 2.3e-115 385.7 0.0 3.7e-115 385.0 0.0 1.3 1 1 0 1 1 1 1 CoA-transferase family III UPRTase PF14681.6 ORX70857.1 - 3e-63 213.0 0.1 3.5e-63 212.8 0.1 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ORX70857.1 - 5.5e-08 32.5 0.1 1.3e-07 31.3 0.1 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain VASt PF16016.5 ORX70858.1 - 3.2e-20 73.1 0.3 4.7e-20 72.5 0.3 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ORX70859.1 - 2.3e-26 91.9 0.0 3.7e-26 91.3 0.0 1.2 1 0 0 1 1 1 1 GRAM domain Hid1 PF12722.7 ORX70859.1 - 0.17 10.0 0.8 0.29 9.2 0.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.12 ORX70859.1 - 1.8 6.7 9.7 2.7 6.1 9.7 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ORX70859.1 - 6.8 4.9 7.6 11 4.2 7.6 1.3 1 0 0 1 1 1 0 CDC45-like protein SCA7 PF08313.12 ORX70860.1 - 4.3e-20 71.4 1.3 1.6e-19 69.5 1.3 2.0 1 0 0 1 1 1 1 SCA7, zinc-binding domain PPP4R2 PF09184.11 ORX70860.1 - 0.098 12.2 11.2 0.17 11.5 11.2 1.4 1 0 0 1 1 1 0 PPP4R2 Glyco_hydro_20 PF00728.22 ORX70861.1 - 1e-95 321.1 0.1 1.5e-95 320.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70861.1 - 2.8e-15 57.2 0.0 6e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX70861.1 - 0.0059 17.4 0.1 0.016 16.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 MFS_1 PF07690.16 ORX70862.1 - 9.2e-27 93.9 39.2 6.4e-15 54.9 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 ORX70862.1 - 0.046 13.6 0.5 0.046 13.6 0.5 2.2 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 MIT PF04212.18 ORX70864.1 - 8.2e-10 38.6 0.0 1.7e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Glyco_hydro_20 PF00728.22 ORX70865.1 - 2.7e-84 283.6 0.0 4.1e-84 283.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70865.1 - 1.5e-08 35.4 0.0 5.1e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX70865.1 - 0.004 17.9 0.0 0.0091 16.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 RNR_N PF08343.10 ORX70865.1 - 0.11 12.6 0.9 0.96 9.5 0.1 2.5 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal 7tm_3 PF00003.22 ORX70866.1 - 0.064 13.0 20.4 0.088 12.5 20.4 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR PgaD PF13994.6 ORX70866.1 - 1.3 9.1 8.5 0.24 11.4 3.2 2.4 1 1 1 2 2 2 0 PgaD-like protein 7tm_3 PF00003.22 ORX70867.1 - 0.00029 20.6 28.2 0.00042 20.1 28.2 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR TMEM239 PF15841.5 ORX70869.1 - 0.028 14.3 0.6 0.078 12.9 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 239 family 7tm_3 PF00003.22 ORX70870.1 - 0.00029 20.6 28.2 0.00042 20.1 28.2 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX70871.1 - 0.064 13.0 20.4 0.088 12.5 20.4 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR PgaD PF13994.6 ORX70871.1 - 1.3 9.1 8.5 0.24 11.4 3.2 2.4 1 1 1 2 2 2 0 PgaD-like protein 7tm_3 PF00003.22 ORX70872.1 - 0.028 14.2 22.8 0.043 13.6 22.8 1.2 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX70873.1 - 0.032 13.9 17.6 0.043 13.5 17.6 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX70874.1 - 0.0018 18.1 25.6 0.0025 17.6 25.6 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1636 PF07845.11 ORX70875.1 - 2.8e-19 69.7 4.4 9.8e-18 64.7 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1636) PFK PF00365.20 ORX70876.1 - 1.2e-188 625.3 2.3 1.4e-104 349.5 0.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase WD40 PF00400.32 ORX70877.1 - 2.2 9.3 7.7 86 4.2 1.2 4.7 4 1 0 4 4 4 0 WD domain, G-beta repeat K-cyclin_vir_C PF09080.10 ORX70879.1 - 0.056 13.9 0.2 0.092 13.2 0.2 1.6 1 1 0 1 1 1 0 K cyclin, C terminal Gcn1_N PF12074.8 ORX70879.1 - 0.067 12.5 0.0 0.093 12.0 0.0 1.2 1 1 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal zf-C2H2 PF00096.26 ORX70880.1 - 1.3e-16 60.0 18.5 2.4e-07 30.8 3.0 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX70880.1 - 3e-14 52.7 12.3 3.7e-10 39.8 1.7 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX70880.1 - 1.3e-11 44.3 16.3 3.3e-06 27.5 2.1 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX70880.1 - 6.4e-07 29.2 10.3 0.00067 19.6 0.2 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX70880.1 - 3.3e-06 27.2 4.1 0.037 14.3 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 ORX70880.1 - 1.9e-05 24.3 2.9 1.9e-05 24.3 2.9 1.9 1 1 1 2 2 2 1 GAGA factor zf-met PF12874.7 ORX70880.1 - 9.3e-05 22.7 6.3 0.017 15.5 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX70880.1 - 0.00049 19.8 9.7 0.017 14.9 0.1 3.0 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 ORX70880.1 - 0.00081 19.7 3.8 0.015 15.6 1.2 2.3 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) DZR PF12773.7 ORX70880.1 - 0.0012 18.8 0.5 0.0016 18.4 0.5 1.2 1 0 0 1 1 1 1 Double zinc ribbon IBR PF01485.21 ORX70880.1 - 0.0056 16.9 0.8 0.0072 16.5 0.8 1.1 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-C2HC_2 PF13913.6 ORX70880.1 - 0.006 16.5 0.4 0.006 16.5 0.4 2.6 3 0 0 3 3 2 1 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 ORX70880.1 - 0.0061 16.7 2.9 0.17 12.0 2.9 2.2 1 1 2 3 3 3 3 Zinc ribbon domain zf-RING_7 PF02591.15 ORX70880.1 - 0.0097 16.1 1.2 0.32 11.2 0.1 2.3 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf-C2HE PF16278.5 ORX70880.1 - 0.012 16.1 10.2 0.24 11.8 4.2 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_4 PF13717.6 ORX70880.1 - 0.013 15.4 1.6 2.9 7.9 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-Di19 PF05605.12 ORX70880.1 - 0.015 15.6 1.3 0.015 15.6 1.3 1.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.6 ORX70880.1 - 0.017 15.0 0.7 0.79 9.7 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF2256 PF10013.9 ORX70880.1 - 0.026 14.6 1.8 5 7.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF2321 PF10083.9 ORX70880.1 - 0.046 13.4 0.1 0.047 13.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_9 PF16293.5 ORX70880.1 - 0.046 13.6 2.4 0.066 13.1 0.1 2.2 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) Elf1 PF05129.13 ORX70880.1 - 0.046 13.8 2.1 0.077 13.0 2.1 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Sgf11 PF08209.11 ORX70880.1 - 0.063 12.8 2.1 1 9.0 0.2 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) FYVE PF01363.21 ORX70880.1 - 0.075 13.2 4.4 0.18 11.9 4.4 1.7 1 1 0 1 1 1 0 FYVE zinc finger Zn-C2H2_12 PF18112.1 ORX70880.1 - 0.085 13.3 7.4 0.33 11.5 1.3 2.7 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain Rad50_zn_hook PF04423.14 ORX70880.1 - 0.15 11.9 0.4 0.15 11.9 0.4 2.1 1 1 1 2 2 2 0 Rad50 zinc hook motif zf_C2H2_ZHX PF18387.1 ORX70880.1 - 0.21 11.3 7.6 5.9 6.6 0.1 3.0 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain TF_Zn_Ribbon PF08271.12 ORX70880.1 - 0.22 11.1 4.6 3.7 7.1 5.0 2.1 1 1 1 2 2 2 0 TFIIB zinc-binding C1_4 PF07975.12 ORX70880.1 - 0.27 11.5 4.4 1.7 9.0 4.2 1.9 1 1 1 2 2 2 0 TFIIH C1-like domain FYDLN_acid PF09538.10 ORX70880.1 - 0.27 11.9 1.7 4.9 7.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-LYAR PF08790.11 ORX70880.1 - 0.28 11.1 6.3 2.1 8.3 0.1 3.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger TRAF6_Z2 PF18048.1 ORX70880.1 - 0.6 10.3 10.8 0.17 12.0 4.8 2.9 3 1 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 zf-LITAF-like PF10601.9 ORX70880.1 - 0.73 10.1 5.4 3.7 7.9 0.3 2.2 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain zinc_ribbon_5 PF13719.6 ORX70880.1 - 1.3 8.8 4.1 10 5.9 4.2 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-AN1 PF01428.16 ORX70880.1 - 2.4 8.4 9.9 13 6.1 3.4 2.7 1 1 1 2 2 2 0 AN1-like Zinc finger DUF4763 PF15960.5 ORX70881.1 - 0.039 13.3 0.2 0.064 12.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) ABC_membrane PF00664.23 ORX70882.1 - 1.6e-36 126.4 3.0 2.3e-36 125.9 3.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX70882.1 - 2.2e-34 118.9 0.0 4.1e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX70882.1 - 1.9e-06 27.5 0.0 9.5e-05 21.9 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX70882.1 - 6.1e-05 23.5 0.1 0.00021 21.7 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ORX70882.1 - 0.00046 19.8 0.2 0.027 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX70882.1 - 0.00084 19.6 0.3 0.0092 16.3 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ORX70882.1 - 0.02 14.6 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 ORX70882.1 - 0.023 14.4 0.0 0.3 10.8 0.0 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_33 PF13671.6 ORX70882.1 - 0.037 14.2 0.0 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ORX70882.1 - 0.038 13.7 0.0 0.22 11.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX70882.1 - 0.046 14.3 0.0 0.15 12.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain Med12 PF09497.10 ORX70882.1 - 0.047 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Transcription mediator complex subunit Med12 RsgA_GTPase PF03193.16 ORX70882.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PRK PF00485.18 ORX70882.1 - 0.089 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 ORX70882.1 - 0.09 12.1 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.26 ORX70882.1 - 0.093 12.4 0.0 15 5.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_membrane_2 PF06472.15 ORX70882.1 - 0.094 12.1 0.7 0.16 11.3 0.7 1.5 1 1 0 1 1 1 0 ABC transporter transmembrane region 2 SbcCD_C PF13558.6 ORX70882.1 - 0.1 12.9 0.4 0.65 10.3 0.4 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.20 ORX70882.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase G-alpha PF00503.20 ORX70882.1 - 0.18 10.9 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 ORX70882.1 - 0.27 10.9 0.0 0.4 10.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 ORX70883.1 - 3.2e-79 266.1 0.5 4.4e-79 265.7 0.5 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ORX70883.1 - 2.2e-08 33.9 0.2 3.3e-07 30.1 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX70883.1 - 5e-05 22.9 0.1 0.0037 16.8 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B Arf PF00025.21 ORX70883.1 - 5.1e-05 22.8 0.0 0.065 12.7 0.0 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family MeaB PF03308.16 ORX70883.1 - 8.7e-05 21.6 0.0 0.26 10.3 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ORX70883.1 - 0.00017 21.6 0.0 0.0024 17.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ORX70883.1 - 0.00045 20.0 0.2 0.0078 16.0 0.0 2.7 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 ORX70883.1 - 0.00052 20.6 0.2 0.16 12.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 ORX70883.1 - 0.00062 19.0 0.0 0.0031 16.7 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain Gtr1_RagA PF04670.12 ORX70883.1 - 0.00066 19.1 0.0 0.019 14.3 0.0 2.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region NACHT PF05729.12 ORX70883.1 - 0.00091 19.2 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 ORX70883.1 - 0.0011 19.2 0.0 0.0024 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.10 ORX70883.1 - 0.0013 18.2 0.0 0.56 9.6 0.0 2.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ORX70883.1 - 0.0017 17.6 0.7 0.012 14.8 0.0 2.5 3 1 0 3 3 3 1 G-protein alpha subunit AAA_16 PF13191.6 ORX70883.1 - 0.0019 18.6 0.0 0.0081 16.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 ORX70883.1 - 0.0022 17.6 0.0 0.34 10.5 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 ORX70883.1 - 0.0022 18.6 0.3 0.038 14.5 0.3 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ORX70883.1 - 0.0022 17.3 0.0 0.0043 16.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin SRP54 PF00448.22 ORX70883.1 - 0.0028 17.3 0.0 0.0073 16.0 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ORX70883.1 - 0.0038 17.5 0.0 0.025 14.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain 6PF2K PF01591.18 ORX70883.1 - 0.0044 16.4 0.0 0.0093 15.3 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_7 PF12775.7 ORX70883.1 - 0.0046 16.5 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ORX70883.1 - 0.0046 16.7 0.6 0.0071 16.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain Not3 PF04065.15 ORX70883.1 - 0.0049 16.3 1.7 0.01 15.3 1.7 1.4 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component AAA_5 PF07728.14 ORX70883.1 - 0.0067 16.4 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ORX70883.1 - 0.0083 16.0 0.1 5.6 6.8 0.0 2.9 3 1 0 3 3 2 0 RsgA GTPase AAA_30 PF13604.6 ORX70883.1 - 0.009 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Ras PF00071.22 ORX70883.1 - 0.011 15.4 0.0 1.7 8.3 0.0 2.5 2 1 0 2 2 2 0 Ras family Roc PF08477.13 ORX70883.1 - 0.011 15.9 0.1 0.39 10.9 0.0 2.6 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 ORX70883.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 ORX70883.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_19 PF13245.6 ORX70883.1 - 0.043 14.2 0.0 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 ORX70883.1 - 0.06 13.1 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.14 ORX70883.1 - 0.096 12.6 0.2 0.27 11.1 0.0 1.8 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 ORX70883.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 ORX70883.1 - 0.12 12.6 0.1 0.75 10.0 0.0 2.2 3 0 0 3 3 2 0 AAA domain CLP1_P PF16575.5 ORX70883.1 - 0.13 12.0 0.0 0.83 9.4 0.0 2.2 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_29 PF13555.6 ORX70883.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain V-ATPase_C PF03223.15 ORX70884.1 - 1.5e-117 393.1 0.3 1.7e-117 392.9 0.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF1323 PF07037.11 ORX70884.1 - 0.025 15.0 0.1 7.5 7.0 0.0 2.5 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) Cep57_MT_bd PF06657.13 ORX70884.1 - 0.053 14.0 0.1 0.36 11.3 0.0 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 RPN7 PF10602.9 ORX70885.1 - 3.5e-12 46.4 0.4 3.1e-11 43.3 0.3 2.6 1 1 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ORX70885.1 - 1.8e-11 44.5 0.3 4e-11 43.4 0.3 1.6 1 0 0 1 1 1 1 PCI domain MatE PF01554.18 ORX70886.1 - 3.7e-38 130.7 28.7 5e-21 75.0 1.4 3.0 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX70886.1 - 1.1e-05 25.6 5.5 1.1e-05 25.6 5.5 3.9 3 1 2 5 5 5 1 Polysaccharide biosynthesis C-terminal domain RNase_PH PF01138.21 ORX70887.1 - 4.3e-27 95.2 0.1 6.4e-27 94.6 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX70887.1 - 0.022 14.8 0.1 0.039 14.0 0.1 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 MatE PF01554.18 ORX70890.1 - 2.7e-32 111.7 26.7 4.8e-16 58.8 11.2 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ORX70890.1 - 0.0082 16.2 12.4 0.0082 16.2 12.4 3.6 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Paf67 PF10255.9 ORX70891.1 - 1.9e-150 501.4 0.6 3.7e-150 500.4 0.6 1.5 1 1 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 ORX70891.1 - 0.0015 18.5 0.0 0.013 15.5 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX70891.1 - 0.0016 18.7 0.1 0.0078 16.5 0.1 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX70891.1 - 0.015 15.1 0.1 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX70891.1 - 0.038 14.6 0.0 0.89 10.3 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX70891.1 - 0.086 13.4 0.1 5.7 7.5 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Spt5_N PF11942.8 ORX70891.1 - 0.13 13.3 5.7 0.48 11.4 0.6 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Peptidase_M3 PF01432.20 ORX70892.1 - 1.1e-135 453.5 0.9 1.4e-135 453.1 0.9 1.1 1 0 0 1 1 1 1 Peptidase family M3 Glyco_hydro_17 PF00332.18 ORX70893.1 - 1.3e-19 71.0 3.2 7.2e-12 45.5 1.4 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 VP4_2 PF08935.10 ORX70893.1 - 0.028 15.0 0.5 0.071 13.7 0.5 1.6 1 0 0 1 1 1 0 Viral protein VP4 subunit Stealth_CR1 PF17101.5 ORX70893.1 - 0.089 12.5 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 Peptidase_C54 PF03416.19 ORX70894.1 - 5.5e-79 265.4 0.0 6.6e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 ORX70894.1 - 0.00061 19.3 0.4 0.0029 17.1 0.3 2.0 2 0 0 2 2 2 1 Peptidase family C78 PDH PF02153.17 ORX70895.1 - 3.8e-06 26.1 0.0 6.8e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 ORX70895.1 - 6.9e-05 23.4 0.0 0.00014 22.4 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ORX70895.1 - 0.00045 19.6 0.0 0.00085 18.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ORX70895.1 - 0.00077 19.4 0.0 0.0022 17.9 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ORX70895.1 - 0.00098 19.3 0.0 0.0026 17.9 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ORX70895.1 - 0.0083 15.8 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Phage_fiber_C PF06820.12 ORX70895.1 - 0.023 15.0 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative prophage tail fibre C-terminus Phage_lysozyme PF00959.19 ORX70896.1 - 2.2e-11 44.2 0.0 3e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX70896.1 - 8.1e-06 26.0 0.3 2e-05 24.8 0.1 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain TPR_2 PF07719.17 ORX70898.1 - 0.04 14.0 1.3 48 4.4 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 ORX70898.1 - 4.2 7.6 8.2 2.1 8.6 0.9 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat NAPRTase PF04095.16 ORX70899.1 - 3.8e-28 98.7 0.0 5.4e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 ORX70899.1 - 3e-15 56.4 0.0 6.6e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5598) F-box-like PF12937.7 ORX70902.1 - 0.00023 21.0 0.8 0.00077 19.3 0.0 2.3 3 0 0 3 3 3 1 F-box-like DSPc PF00782.20 ORX70903.1 - 6.8e-15 55.1 0.0 7.8e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain SNF2_N PF00176.23 ORX70904.1 - 1.4e-21 76.7 0.1 8.8e-21 74.0 0.1 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain RhoGEF PF00621.20 ORX70905.1 - 1.5e-16 61.1 0.1 2.8e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ORX70905.1 - 0.00027 21.2 0.0 0.0013 19.0 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain eIF-5_eIF-2B PF01873.17 ORX70906.1 - 2.4e-40 137.0 0.0 4.7e-40 136.1 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.15 ORX70906.1 - 0.022 14.6 0.0 0.066 13.1 0.0 1.8 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Lar_restr_allev PF14354.6 ORX70906.1 - 0.098 13.0 2.3 0.51 10.7 2.2 2.2 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF35_N PF12172.8 ORX70906.1 - 0.18 11.7 1.3 0.46 10.4 0.2 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) ThiF PF00899.21 ORX70907.1 - 4.1e-103 344.0 0.0 1.5e-70 237.3 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ORX70907.1 - 3.5e-71 240.1 0.2 6e-42 144.3 0.2 2.2 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 ORX70907.1 - 1.3e-32 111.8 0.3 2.6e-32 110.8 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 ORX70907.1 - 8.2e-32 109.8 0.3 1.6e-31 108.9 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 ORX70907.1 - 8.2e-25 86.8 0.0 1.9e-24 85.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle p450 PF00067.22 ORX70908.1 - 1.2e-61 208.9 0.0 1.6e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NUDIX PF00293.28 ORX70909.1 - 1e-14 54.7 0.0 1.7e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain RtcB PF01139.17 ORX70909.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB Mito_carr PF00153.27 ORX70910.1 - 5.3e-17 61.5 0.2 1.3e-06 28.2 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein PRIMA1 PF16101.5 ORX70911.1 - 1.5 8.9 4.3 2.5 8.1 4.3 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ODV-E18 PF10717.9 ORX70912.1 - 0.097 12.6 1.0 0.27 11.1 1.0 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 OAD_gamma PF04277.13 ORX70912.1 - 0.14 12.8 0.0 0.14 12.8 0.0 3.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain EphA2_TM PF14575.6 ORX70912.1 - 0.2 12.5 1.2 0.36 11.7 1.1 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 ORX70912.1 - 9.8 5.8 7.1 19 4.9 7.1 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family OmpH PF03938.14 ORX70913.1 - 0.0083 16.5 0.2 0.016 15.5 0.2 1.4 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF416 PF04222.12 ORX70913.1 - 0.036 13.5 1.7 0.054 12.9 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF416) KxDL PF10241.9 ORX70913.1 - 0.23 11.8 2.7 0.42 10.9 2.3 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein Uds1 PF15456.6 ORX70913.1 - 0.27 11.4 6.9 3.4 7.8 6.9 2.3 1 1 0 1 1 1 0 Up-regulated During Septation F-box-like PF12937.7 ORX70914.1 - 0.00047 20.0 0.7 0.0015 18.4 0.5 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX70914.1 - 0.27 11.2 2.1 0.83 9.6 0.1 2.9 3 0 0 3 3 3 0 F-box domain SMN PF06003.12 ORX70915.1 - 0.0011 18.3 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 ORX70915.1 - 0.0055 16.7 0.0 0.0097 15.9 0.0 1.4 1 0 0 1 1 1 1 Tudor domain Tudor_2 PF18104.1 ORX70915.1 - 0.033 13.8 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain DUF5543 PF17697.1 ORX70915.1 - 0.099 12.9 1.0 0.17 12.2 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5543) Sel1 PF08238.12 ORX70916.1 - 7.7e-16 58.2 20.3 8.9e-06 26.2 0.0 8.1 9 0 0 9 9 9 4 Sel1 repeat TPR_1 PF00515.28 ORX70916.1 - 2.8 7.9 4.7 17 5.4 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat KilA-N PF04383.13 ORX70920.1 - 0.00079 19.2 0.0 0.0038 17.0 0.0 1.9 1 1 0 1 1 1 1 KilA-N domain MID_MedPIWI PF18296.1 ORX70921.1 - 0.0061 16.4 0.0 2.7 7.7 0.0 2.5 1 1 0 2 2 2 2 MID domain of medPIWI Med13_C PF06333.12 ORX70921.1 - 0.02 14.2 0.0 0.02 14.2 0.0 2.6 2 1 1 3 3 3 0 Mediator complex subunit 13 C-terminal domain Hph PF13694.6 ORX70923.1 - 0.0039 17.5 1.2 0.0041 17.4 1.2 1.0 1 0 0 1 1 1 1 Sec63/Sec62 complex-interacting family zf-met PF12874.7 ORX70923.1 - 0.015 15.7 0.0 0.035 14.5 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ORX70923.1 - 0.016 15.6 0.1 0.032 14.7 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX70923.1 - 0.017 15.9 0.4 0.035 14.9 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ORX70923.1 - 0.057 14.1 1.4 0.17 12.5 0.8 1.8 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Peroxin-3 PF04882.12 ORX70923.1 - 0.2 10.6 3.0 0.24 10.4 3.0 1.0 1 0 0 1 1 1 0 Peroxin-3 DUF4680 PF15730.5 ORX70923.1 - 1 9.7 6.5 1.2 9.5 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) Ion_trans_2 PF07885.16 ORX70924.1 - 0.14 12.2 0.1 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Ion channel DUF5014 PF16406.5 ORX70924.1 - 0.14 12.5 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5014) Romo1 PF10247.9 ORX70927.1 - 1.5e-23 83.0 10.4 1.9e-23 82.6 10.4 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 IGPD PF00475.18 ORX70928.1 - 5.4e-56 188.9 0.4 7.2e-56 188.5 0.4 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase 5_nucleotid_C PF02872.18 ORX70929.1 - 1.9e-40 138.7 0.0 2.9e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ORX70929.1 - 1.3e-08 35.6 0.1 2.6e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TAF1_subA PF14929.6 ORX70930.1 - 0.00024 20.6 0.1 0.00074 19.0 0.1 1.7 1 1 0 1 1 1 1 TAF RNA Polymerase I subunit A HEAT_2 PF13646.6 ORX70930.1 - 0.0017 18.7 0.1 0.0046 17.3 0.1 1.7 1 0 0 1 1 1 1 HEAT repeats TPR_19 PF14559.6 ORX70930.1 - 0.0041 17.6 2.0 0.0086 16.6 0.4 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX70930.1 - 0.02 15.7 0.7 2 9.4 0.6 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DLIC PF05783.11 ORX70931.1 - 1.9e-65 221.5 0.4 5.3e-57 193.7 0.0 3.0 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 ORX70931.1 - 0.004 17.5 0.0 0.01 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 ORX70931.1 - 0.023 14.1 0.0 0.053 12.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 ORX70931.1 - 0.049 13.8 0.0 0.14 12.4 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ORX70931.1 - 0.11 11.8 0.1 0.29 10.4 0.0 1.7 2 0 0 2 2 2 0 Septin SRPRB PF09439.10 ORX70931.1 - 0.12 11.8 0.1 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX70931.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 Ras family FeoB_N PF02421.18 ORX70931.1 - 0.18 11.3 0.1 0.48 9.9 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B Rib_5-P_isom_A PF06026.14 ORX70932.1 - 8.7e-57 191.5 0.0 1.6e-56 190.7 0.0 1.4 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Arb2 PF09757.9 ORX70933.1 - 0.00023 20.4 0.0 0.00031 19.9 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Glyco_hydro_20 PF00728.22 ORX70934.1 - 1.5e-80 271.3 7.4 9.2e-58 196.3 0.6 2.6 1 1 1 2 2 2 2 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX70934.1 - 4.6e-10 40.3 0.3 9.3e-07 29.6 0.0 2.7 1 1 1 2 2 2 2 beta-acetyl hexosaminidase like Cellulase PF00150.18 ORX70934.1 - 0.0068 15.9 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MOZ_SAS PF01853.18 ORX70935.1 - 2.8e-60 203.0 0.0 7.2e-60 201.7 0.0 1.7 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX70935.1 - 8.9e-22 76.5 6.4 2.6e-21 75.0 6.4 1.9 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 ORX70935.1 - 7.4e-12 45.0 0.0 1.7e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 ORX70935.1 - 0.00021 21.7 0.0 0.00042 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX70935.1 - 0.0028 17.9 0.0 0.0059 16.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family UFC1 PF08694.11 ORX70935.1 - 0.013 15.1 0.2 0.73 9.5 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-fold modifier-conjugating enzyme 1 WD40 PF00400.32 ORX70936.1 - 7.3e-09 36.1 10.2 0.003 18.3 0.1 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Per1 PF04080.13 ORX70937.1 - 9.6e-90 300.8 14.6 1.2e-89 300.5 14.6 1.1 1 0 0 1 1 1 1 Per1-like family TspO_MBR PF03073.15 ORX70937.1 - 0.076 13.1 10.8 0.04 14.0 6.3 2.5 2 1 0 2 2 2 0 TspO/MBR family Imm70 PF15601.6 ORX70938.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 70 RasGAP PF00616.19 ORX70940.1 - 7.2e-26 91.2 0.0 1.5e-17 64.0 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ORX70940.1 - 1.4e-09 38.2 0.2 9.1e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Lactamase_B PF00753.27 ORX70941.1 - 3.3e-20 73.0 0.7 6.1e-20 72.1 0.7 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ORX70941.1 - 2e-11 43.7 0.0 5.1e-11 42.4 0.0 1.8 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ORX70941.1 - 4.7e-05 23.0 0.1 8.3e-05 22.2 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RNA_pol_Rpb1_5 PF04998.17 ORX70942.1 - 1e-84 284.1 0.0 2.1e-84 283.1 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ORX70942.1 - 3.6e-50 170.4 0.0 7e-50 169.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ORX70942.1 - 1.9e-26 92.9 0.0 4.4e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 ORX70942.1 - 9.3e-25 87.6 0.3 9.6e-23 81.0 0.0 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ORX70942.1 - 2.9e-22 78.6 0.0 2.9e-22 78.6 0.0 2.6 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 UIM PF02809.20 ORX70942.1 - 0.026 14.4 2.2 0.084 12.8 2.2 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif Codanin-1_C PF15296.6 ORX70942.1 - 1.7 8.8 4.6 48 4.1 0.1 3.7 4 0 0 4 4 4 0 Codanin-1 C-terminus Aldo_ket_red PF00248.21 ORX70943.1 - 5.3e-63 212.9 0.0 6.1e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family G-patch PF01585.23 ORX70945.1 - 3.5e-13 49.2 0.8 8.8e-13 47.9 0.8 1.7 1 0 0 1 1 1 1 G-patch domain Rrn6 PF10214.9 ORX70945.1 - 0.0025 16.4 4.0 0.0028 16.2 4.0 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor G-patch_2 PF12656.7 ORX70945.1 - 0.018 15.1 0.6 0.064 13.3 0.6 2.0 1 0 0 1 1 1 0 G-patch domain SR-25 PF10500.9 ORX70945.1 - 4.8 6.7 16.8 11 5.6 16.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SSB PF00436.25 ORX70946.1 - 2.2e-25 88.7 0.1 2.5e-25 88.5 0.1 1.0 1 0 0 1 1 1 1 Single-strand binding protein family HAGH_C PF16123.5 ORX70947.1 - 3.8e-20 72.2 0.0 6.1e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 ORX70947.1 - 2.4e-10 40.8 3.5 3.9e-09 36.8 3.5 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX70947.1 - 7.5e-05 22.3 0.7 0.0021 17.6 0.6 2.6 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX70947.1 - 0.035 14.0 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Chitin_synth_2 PF03142.15 ORX70949.1 - 3.7e-156 520.8 9.0 9.3e-101 338.0 0.3 3.3 1 1 2 3 3 3 3 Chitin synthase DEK_C PF08766.11 ORX70949.1 - 3.5e-20 71.7 0.5 1.8e-19 69.4 0.7 2.0 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX70949.1 - 1.7e-07 31.4 0.0 5.7e-07 29.7 0.0 1.9 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX70949.1 - 2.4e-07 30.9 3.2 5.2e-07 29.8 3.2 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 SRP54_N PF02881.19 ORX70949.1 - 0.035 14.3 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain Glyco_transf_21 PF13506.6 ORX70949.1 - 0.087 12.3 0.0 2.6 7.5 0.0 2.9 3 0 0 3 3 3 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX70949.1 - 0.1 12.4 0.0 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 PCNA_N PF00705.18 ORX70950.1 - 6.2e-47 158.5 5.1 6.2e-47 158.5 3.4 1.8 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ORX70950.1 - 2.7e-45 153.7 0.4 4.5e-44 149.7 0.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 ORX70950.1 - 1.3e-07 31.4 0.2 1.5e-07 31.1 0.2 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 ORX70950.1 - 4e-06 26.1 2.2 9.3e-05 21.6 2.1 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 ORX70950.1 - 0.032 13.3 0.1 0.66 9.0 0.0 2.1 2 0 0 2 2 2 0 Hus1-like protein Bac_A_amyl_C PF18612.1 ORX70950.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain Chitin_synth_2 PF03142.15 ORX70951.1 - 4.2e-140 467.8 4.6 3.1e-75 253.8 3.1 2.3 2 0 0 2 2 2 2 Chitin synthase DEK_C PF08766.11 ORX70951.1 - 1.1e-19 70.1 0.0 3.9e-19 68.3 0.0 1.9 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.28 ORX70951.1 - 6.6e-07 29.4 1.1 5.4e-05 23.3 0.1 2.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 ORX70951.1 - 1.4e-05 25.1 0.4 0.0011 18.9 0.1 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX70951.1 - 0.0067 16.4 0.0 0.0067 16.4 0.0 3.8 4 0 0 4 4 4 2 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX70951.1 - 0.029 13.8 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 SUIM_assoc PF16619.5 ORX70951.1 - 5.7 7.1 10.9 1.1 9.3 3.6 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 ORX70951.1 - 9 6.2 6.6 14 5.5 6.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Adap_comp_sub PF00928.21 ORX70952.1 - 9.3e-38 130.1 0.0 8.9e-26 90.8 0.0 2.9 1 1 0 2 2 2 2 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX70952.1 - 1.9e-07 31.1 0.1 3.7e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain WD40 PF00400.32 ORX70953.1 - 0.057 14.3 0.1 0.057 14.3 0.1 3.9 3 2 1 4 4 4 0 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 ORX70955.1 - 0.00015 21.3 4.9 0.00026 20.6 4.9 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 ORX70955.1 - 0.014 15.3 2.5 0.032 14.1 2.5 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_16 PF17034.5 ORX70955.1 - 0.04 14.1 0.7 0.075 13.2 0.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family DUF3781 PF12636.7 ORX70956.1 - 0.078 12.9 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3781) MAPEG PF01124.18 ORX70957.1 - 1.4e-17 63.9 0.0 1.7e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 MAPEG family DUF417 PF04224.12 ORX70957.1 - 0.031 13.8 0.1 0.067 12.7 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function, DUF417 MAPEG PF01124.18 ORX70958.1 - 4.3e-08 33.1 0.0 5.3e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 MAPEG family DUF3872 PF12988.7 ORX70959.1 - 0.15 11.9 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Beta_elim_lyase PF01212.21 ORX70960.1 - 9.7e-77 258.1 0.0 1.3e-76 257.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ORX70960.1 - 2.8e-09 36.6 0.0 4.4e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ORX70960.1 - 5.3e-07 29.3 0.0 0.0029 17.0 0.1 2.4 2 1 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ORX70960.1 - 7e-07 28.1 0.1 3.1e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ORX70960.1 - 0.0048 15.9 0.1 0.094 11.6 0.0 2.2 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ORX70961.1 - 1e-73 248.2 0.0 1.2e-73 248.0 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ORX70961.1 - 1.1e-07 31.3 0.0 3.6e-06 26.4 0.0 2.2 1 1 1 2 2 2 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ORX70961.1 - 0.0002 20.8 0.0 0.002 17.5 0.0 2.4 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ORX70961.1 - 0.00024 19.8 0.0 0.00047 18.8 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme MIP PF00230.20 ORX70963.1 - 1.4e-49 168.9 5.9 1.8e-49 168.5 5.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.20 ORX70964.1 - 1.2e-47 162.5 6.2 6.9e-47 160.0 6.2 1.8 1 1 0 1 1 1 1 Major intrinsic protein LtrA PF06772.11 ORX70964.1 - 0.00085 18.6 1.8 0.087 12.0 0.1 2.7 3 0 0 3 3 3 2 Bacterial low temperature requirement A protein (LtrA) DUF2484 PF10658.9 ORX70964.1 - 1.1 9.7 5.2 4.3 7.7 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2484) MFS_1 PF07690.16 ORX70965.1 - 2.5e-35 122.0 47.6 2.5e-35 122.0 47.6 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX70965.1 - 6.5e-09 34.7 15.8 8.6e-09 34.3 15.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 ORX70965.1 - 0.23 9.7 18.3 0.17 10.2 4.9 2.5 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family YfhO PF09586.10 ORX70965.1 - 7.3 4.7 6.7 9 4.4 5.9 1.5 1 1 0 1 1 1 0 Bacterial membrane protein YfhO CLTH PF10607.9 ORX70966.1 - 5.7e-34 117.1 0.2 7.3e-34 116.8 0.2 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ORX70966.1 - 6.8e-11 41.7 0.3 1.4e-10 40.7 0.3 1.6 1 0 0 1 1 1 1 LisH P33MONOX PF15302.6 ORX70966.1 - 0.043 13.5 0.1 0.057 13.1 0.1 1.1 1 0 0 1 1 1 0 P33 mono-oxygenase Foie-gras_1 PF11817.8 ORX70967.1 - 3e-05 23.8 7.1 0.00017 21.3 0.7 3.4 3 1 1 4 4 4 1 Foie gras liver health family 1 Paf67 PF10255.9 ORX70967.1 - 0.079 11.9 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 Gryzun PF07919.12 ORX70968.1 - 0.00056 18.8 0.1 0.0008 18.3 0.1 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Glyco_transf_15 PF01793.16 ORX70969.1 - 3.4e-111 371.6 4.7 5.3e-111 371.0 4.7 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase AAA_lid_2 PF17863.1 ORX70969.1 - 0.092 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA lid domain FA_desaturase PF00487.24 ORX70970.1 - 1.4e-15 57.8 10.5 2.1e-15 57.3 10.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase FAM184 PF15665.5 ORX70971.1 - 0.021 14.6 2.4 0.024 14.4 2.4 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B DUF480 PF04337.12 ORX70971.1 - 0.032 14.3 0.7 0.042 14.0 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF480 FtsJ PF01728.19 ORX70973.1 - 6.5e-24 85.0 0.0 1.2e-23 84.2 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Med14 PF08638.11 ORX70973.1 - 0.12 11.8 0.4 0.2 11.1 0.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit MED14 Prefoldin_2 PF01920.20 ORX70974.1 - 3.7e-16 59.0 5.4 4.6e-16 58.7 5.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit LIP PF03583.14 ORX70974.1 - 0.058 12.7 0.1 0.076 12.3 0.0 1.3 1 1 0 1 1 1 0 Secretory lipase Baculo_PEP_C PF04513.12 ORX70974.1 - 0.12 12.4 2.6 8.9 6.4 0.5 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Turandot PF07240.11 ORX70974.1 - 0.12 12.3 0.2 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot DUF3683 PF12447.8 ORX70974.1 - 0.32 11.1 2.6 1 9.5 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3683) DUF4201 PF13870.6 ORX70974.1 - 0.34 10.6 8.2 2.4 7.9 8.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 ORX70974.1 - 0.36 10.1 6.1 0.42 9.9 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran_CTD PF16326.5 ORX70974.1 - 0.49 10.7 7.1 0.52 10.6 1.1 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 ORX70974.1 - 0.73 10.3 2.7 20 5.7 0.2 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Spc24 PF08286.11 ORX70974.1 - 4.3 7.6 7.2 5.8 7.2 1.3 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Ribosomal_L29 PF00831.23 ORX70975.1 - 4.2e-18 65.0 6.7 2.2e-17 62.8 3.8 2.3 2 0 0 2 2 2 1 Ribosomal L29 protein DUF3106 PF11304.8 ORX70975.1 - 0.023 15.1 1.6 0.023 15.1 1.6 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3106) PRA-PH PF01503.17 ORX70975.1 - 0.041 14.3 0.6 0.12 12.9 0.1 1.8 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase DCB PF16213.5 ORX70977.1 - 3.7e-52 176.6 6.4 1.3e-51 174.7 6.4 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 ORX70977.1 - 5.4e-33 114.1 2.3 1.9e-32 112.4 0.1 3.3 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 ORX70977.1 - 2.3e-31 108.8 9.6 1.2e-25 89.9 4.8 4.0 3 1 0 3 3 3 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 ORX70977.1 - 5.2e-06 26.2 0.8 0.0013 18.6 0.0 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF1981) Zn_clus PF00172.18 ORX70978.1 - 2.9e-06 27.3 10.2 5.3e-06 26.5 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX70978.1 - 0.001 18.2 0.1 0.0026 16.8 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 ORX70980.1 - 1.3e-12 47.3 0.0 2.1e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Syntaxin_2 PF14523.6 ORX70981.1 - 3e-27 94.9 17.3 3e-23 82.1 10.0 2.3 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.19 ORX70981.1 - 2.4e-15 56.2 4.9 1.9e-13 50.1 0.6 2.9 3 0 0 3 3 3 2 SNARE domain Syntaxin PF00804.25 ORX70981.1 - 9e-07 28.8 17.5 9e-07 28.8 17.5 1.9 2 1 0 2 2 2 1 Syntaxin DUF3878 PF12994.7 ORX70981.1 - 0.0088 15.5 0.9 0.015 14.7 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3878) CHAD PF05235.14 ORX70981.1 - 0.031 14.3 10.5 0.025 14.6 9.6 1.4 1 1 0 1 1 1 0 CHAD domain DUF2207 PF09972.9 ORX70981.1 - 0.15 10.8 4.5 0.25 10.1 0.0 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TMPIT PF07851.13 ORX70981.1 - 0.15 11.2 14.5 47 3.1 14.5 2.5 1 1 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 ORX70981.1 - 0.23 10.0 12.7 0.56 8.8 6.7 2.3 2 1 0 2 2 2 0 Flagellar Assembly Protein A DUF1664 PF07889.12 ORX70981.1 - 0.31 11.1 13.5 1.1 9.2 1.3 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) YtxH PF12732.7 ORX70981.1 - 0.71 10.4 2.4 0.8 10.3 1.0 2.0 2 1 0 2 2 2 0 YtxH-like protein DUF1043 PF06295.12 ORX70981.1 - 1.1 9.3 10.6 1.1 9.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF883 PF05957.13 ORX70981.1 - 1.5 9.5 9.9 8.5 7.1 0.3 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF3675 PF12428.8 ORX70981.1 - 1.7 9.2 5.2 0.4 11.2 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3675) FUSC PF04632.12 ORX70981.1 - 1.9 6.9 5.6 3.5 6.0 5.4 1.4 1 1 1 2 2 2 0 Fusaric acid resistance protein family Synaptobrevin PF00957.21 ORX70981.1 - 4 7.3 7.9 0.25 11.1 1.1 2.5 2 1 1 3 3 3 0 Synaptobrevin NYD-SP28 PF14772.6 ORX70982.1 - 0.0023 18.0 8.1 0.0088 16.1 5.0 2.2 2 0 0 2 2 2 1 Sperm tail PspA_IM30 PF04012.12 ORX70982.1 - 0.054 13.1 15.7 0.11 12.1 1.8 2.1 2 0 0 2 2 2 0 PspA/IM30 family PI3K_P85_iSH2 PF16454.5 ORX70982.1 - 0.12 12.0 4.1 0.21 11.2 4.1 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain HOOK PF05622.12 ORX70982.1 - 0.19 9.8 11.5 0.026 12.7 5.6 1.9 1 1 1 2 2 2 0 HOOK protein Golgin_A5 PF09787.9 ORX70982.1 - 0.41 10.0 9.1 0.89 9.0 8.9 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 ORX70982.1 - 0.8 9.0 11.4 1.2 8.4 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ORX70982.1 - 0.98 8.2 10.6 1.6 7.6 10.6 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 ORX70982.1 - 1.5 9.4 18.5 13 6.3 18.5 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF724 PF05266.14 ORX70982.1 - 1.7 8.5 7.6 3.8 7.3 7.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) PP2C_2 PF13672.6 ORX70982.1 - 2.7 7.6 6.8 0.57 9.8 2.3 1.8 1 1 1 2 2 2 0 Protein phosphatase 2C Snapin_Pallidin PF14712.6 ORX70982.1 - 2.9 8.4 7.9 0.81 10.1 2.2 2.4 2 1 0 2 2 2 0 Snapin/Pallidin CASP_C PF08172.12 ORX70982.1 - 3.5 6.9 8.0 0.45 9.8 2.6 1.9 2 0 0 2 2 2 0 CASP C terminal UPF0242 PF06785.11 ORX70982.1 - 3.9 7.5 9.5 10 6.2 9.5 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 ORX70982.1 - 8 6.7 12.2 16 5.7 7.8 2.2 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 ORX70983.1 - 0.023 13.6 26.1 0.027 13.4 6.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 ORX70983.1 - 0.024 13.8 23.7 0.015 14.4 6.8 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 MscS_porin PF12795.7 ORX70983.1 - 0.06 12.9 34.2 0.11 12.1 34.2 1.4 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain PEPcase_2 PF14010.6 ORX70983.1 - 0.11 11.0 1.3 0.16 10.4 1.3 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Ufd2P_core PF10408.9 ORX70983.1 - 0.17 10.4 4.3 0.22 10.1 4.3 1.2 1 0 0 1 1 1 0 Ubiquitin elongating factor core FAP206 PF12018.8 ORX70983.1 - 0.65 9.5 8.2 0.26 10.8 5.3 1.7 1 1 1 2 2 2 0 Domain of unknown function FAM76 PF16046.5 ORX70983.1 - 0.79 9.0 14.8 0.12 11.7 3.5 2.1 2 0 0 2 2 2 0 FAM76 protein PKcGMP_CC PF16808.5 ORX70983.1 - 1 9.2 8.7 5 7.1 0.1 3.6 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Golgin_A5 PF09787.9 ORX70983.1 - 1.3 8.5 24.8 8.6 5.7 4.7 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 ORX70983.1 - 2 9.1 28.1 6.9 7.3 16.8 3.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RmuC PF02646.16 ORX70983.1 - 2.2 7.4 14.3 1.3 8.1 3.3 2.5 2 1 1 3 3 3 0 RmuC family Laminin_II PF06009.12 ORX70983.1 - 2.9 7.9 14.9 1.3 9.1 8.2 2.4 1 1 1 2 2 2 0 Laminin Domain II Csm1_N PF18504.1 ORX70983.1 - 3.2 8.2 23.8 0.35 11.3 0.9 4.4 3 1 2 5 5 5 0 Csm1 N-terminal domain AAA_13 PF13166.6 ORX70983.1 - 4.4 5.8 17.8 21 3.6 17.2 1.8 1 1 0 1 1 1 0 AAA domain ACCA PF03255.14 ORX70983.1 - 6.1 6.7 12.7 1.3 8.9 1.6 2.4 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TPR_MLP1_2 PF07926.12 ORX70983.1 - 9.4 6.3 30.0 2.6 8.1 6.6 2.4 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 ORX70983.1 - 9.5 5.4 14.3 6.1 6.0 5.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein Tub PF01167.18 ORX70984.1 - 1.3e-46 159.3 0.0 1.5e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Tub family UPF0086 PF01868.16 ORX70985.1 - 1.3e-25 89.1 0.2 2e-25 88.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Nas2_N PF18265.1 ORX70986.1 - 0.14 12.1 0.3 0.57 10.1 0.1 2.1 2 0 0 2 2 2 0 Nas2 N_terminal domain CENP-B_dimeris PF09026.10 ORX70986.1 - 2.6 8.5 5.2 4 7.9 3.0 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CoA_binding_2 PF13380.6 ORX70987.1 - 9.7e-35 119.6 0.0 1.1e-34 119.4 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 ORX70987.1 - 4.6e-05 24.0 0.0 6.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 CoA binding domain FAD_binding_1 PF00667.20 ORX70988.1 - 1.6e-30 106.3 0.0 2.5e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX70988.1 - 1.6e-22 80.3 0.0 3.6e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX70988.1 - 5.3e-14 52.8 0.0 1.3e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ORX70988.1 - 0.0035 17.6 0.0 0.0074 16.5 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin domain FAD_binding_6 PF00970.24 ORX70988.1 - 0.036 14.4 0.0 5 7.5 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain NUDIX PF00293.28 ORX70990.1 - 1.3e-09 38.2 0.0 1.7e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Methyltransf_23 PF13489.6 ORX70991.1 - 1.8e-12 47.4 0.0 2.3e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX70991.1 - 3e-06 27.9 0.0 1.2e-05 26.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX70991.1 - 1e-05 26.1 0.0 0.00013 22.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX70991.1 - 0.00055 20.6 0.0 0.23 12.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX70991.1 - 0.0035 17.1 0.0 0.005 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MARVEL PF01284.23 ORX70992.1 - 1.6e-10 41.2 6.3 2.7e-10 40.5 6.3 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF3094 PF11293.8 ORX70992.1 - 0.081 12.7 0.7 0.51 10.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) MARVEL PF01284.23 ORX70993.1 - 2.3e-07 31.0 14.3 3.8e-07 30.2 14.3 1.4 1 1 0 1 1 1 1 Membrane-associating domain Acetyltransf_1 PF00583.25 ORX70994.1 - 1.1e-14 54.7 0.0 1.3e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX70994.1 - 1.9e-07 31.4 0.0 3e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX70994.1 - 3.1e-05 23.9 0.0 4.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX70994.1 - 0.0041 17.1 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX70994.1 - 0.14 12.8 0.0 0.17 12.5 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GATase_4 PF13230.6 ORX70995.1 - 7.1e-18 64.5 0.2 2.2e-17 62.9 0.2 1.6 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 ORX70995.1 - 1.2e-09 38.4 0.1 2.4e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DMRL_synthase PF00885.19 ORX70996.1 - 4.1e-07 29.9 0.0 4.9e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase AAA_26 PF13500.6 ORX70996.1 - 0.077 12.8 0.0 0.095 12.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain DMRL_synthase PF00885.19 ORX70997.1 - 3.9e-55 185.6 0.1 6e-55 184.9 0.1 1.2 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Brr6_like_C_C PF10104.9 ORX70998.1 - 3.6e-16 59.2 0.3 5.8e-16 58.5 0.3 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain LMBR1 PF04791.16 ORX70998.1 - 0.0044 16.0 0.3 0.0054 15.7 0.3 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein CDC45 PF02724.14 ORX70998.1 - 0.13 10.5 4.4 0.18 10.0 4.4 1.3 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 ORX70998.1 - 0.22 11.2 11.4 0.33 10.7 11.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Hid1 PF12722.7 ORX70998.1 - 0.48 8.5 2.9 0.53 8.4 2.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DMRL_synthase PF00885.19 ORX70999.1 - 2.8e-12 46.7 0.0 5.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase ScsC_N PF18312.1 ORX70999.1 - 0.11 12.3 0.1 0.38 10.6 0.0 1.9 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain Pkinase PF00069.25 ORX71000.1 - 2.1e-54 184.7 0.0 3.2e-54 184.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71000.1 - 8.9e-27 94.0 0.0 1.8e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71000.1 - 2.8e-07 30.2 0.0 4.3e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX71000.1 - 1.2e-05 24.5 0.0 2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX71000.1 - 4.1e-05 22.5 0.0 0.00011 21.1 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX71000.1 - 0.00054 20.0 0.2 0.00054 20.0 0.2 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family TPR_1 PF00515.28 ORX71067.1 - 9.1e-21 72.8 21.3 0.0017 18.1 0.1 12.9 13 0 0 13 13 13 5 Tetratricopeptide repeat TPR_2 PF07719.17 ORX71067.1 - 7e-18 63.2 43.0 0.0036 17.3 0.6 14.1 16 0 0 16 16 14 6 Tetratricopeptide repeat TPR_14 PF13428.6 ORX71067.1 - 1e-13 50.8 64.0 0.00021 21.8 1.2 14.6 8 4 5 14 14 14 6 Tetratricopeptide repeat TPR_12 PF13424.6 ORX71067.1 - 1.5e-13 50.8 44.6 0.012 15.9 0.0 11.3 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.6 ORX71067.1 - 6.8e-12 44.5 24.0 0.36 11.0 0.0 11.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX71067.1 - 9.5e-12 44.2 10.9 1.3 9.4 0.0 10.9 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX71067.1 - 2.6e-11 43.9 50.6 4.5e-06 27.1 0.0 10.5 7 2 4 13 13 11 3 Tetratricopeptide repeat TPR_16 PF13432.6 ORX71067.1 - 2.9e-10 40.6 76.1 0.00071 20.2 0.4 12.6 10 2 4 14 14 13 5 Tetratricopeptide repeat TPR_6 PF13174.6 ORX71067.1 - 5.5e-10 39.2 37.8 1.4 9.8 0.0 14.1 14 0 0 14 14 13 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX71067.1 - 8.7e-08 32.3 17.4 0.00029 21.0 0.0 6.3 6 0 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ORX71067.1 - 1.5e-06 28.1 10.1 7.6 7.2 0.0 9.6 10 1 1 11 11 11 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX71067.1 - 1.8e-06 28.0 0.2 1.8e-06 28.0 0.2 7.8 6 3 2 8 8 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 ORX71067.1 - 0.0027 18.2 19.5 0.19 12.5 2.1 8.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX71067.1 - 0.047 13.4 24.4 1.1 9.0 0.2 9.5 11 1 1 12 12 12 0 TPR repeat TPPII_N PF12583.8 ORX71067.1 - 0.3 11.7 4.2 9.3 6.8 0.1 3.5 3 0 0 3 3 2 0 Tripeptidyl peptidase II N terminal TPR_10 PF13374.6 ORX71067.1 - 1.5 8.8 27.7 46 4.1 0.0 9.9 10 0 0 10 10 10 0 Tetratricopeptide repeat bZIP_1 PF00170.21 ORX71068.1 - 8.9e-10 38.5 12.4 2.4e-09 37.1 12.4 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX71068.1 - 2.4e-05 24.3 16.3 0.00012 22.1 10.8 2.6 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_Maf PF03131.17 ORX71068.1 - 0.00065 20.2 7.9 0.00065 20.2 7.9 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor DUF4618 PF15397.6 ORX71068.1 - 0.0022 17.4 3.8 0.0037 16.7 3.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) YabA PF06156.13 ORX71068.1 - 0.015 15.9 0.0 0.015 15.9 0.0 2.0 3 0 0 3 3 3 0 Initiation control protein YabA Rootletin PF15035.6 ORX71068.1 - 0.019 15.0 6.2 0.03 14.4 6.2 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Macoilin PF09726.9 ORX71068.1 - 0.082 11.5 11.1 0.12 10.9 11.1 1.1 1 0 0 1 1 1 0 Macoilin family CENP-F_leu_zip PF10473.9 ORX71068.1 - 0.11 12.5 7.2 0.053 13.5 3.9 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fungal_TACC PF12709.7 ORX71068.1 - 0.21 12.1 2.5 0.5 10.8 1.8 2.0 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins APG6_N PF17675.1 ORX71068.1 - 0.59 10.7 9.4 1.5 9.4 9.4 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DivIC PF04977.15 ORX71068.1 - 0.64 9.8 4.1 1.6 8.5 2.5 2.5 2 1 0 2 2 2 0 Septum formation initiator TSC22 PF01166.18 ORX71068.1 - 2.7 8.4 5.1 3.7 7.9 1.0 2.7 2 1 1 3 3 3 0 TSC-22/dip/bun family ELP6 PF09807.9 ORX71069.1 - 5.7e-10 39.0 0.1 0.0017 17.8 0.0 2.6 1 1 2 3 3 3 2 Elongation complex protein 6 RNase_H PF00075.24 ORX71071.1 - 2.1e-16 60.4 0.0 3e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 ORX71071.1 - 2.4e-09 37.3 1.2 6.2e-09 36.0 1.2 1.8 1 0 0 1 1 1 1 Caulimovirus viroplasmin DUF2457 PF10446.9 ORX71071.1 - 5.1 6.1 9.7 6.8 5.7 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Astro_capsid_p PF12226.8 ORX71071.1 - 7.9 5.5 9.5 11 5.1 9.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 ORX71071.1 - 8.5 5.6 9.8 12 5.1 9.8 1.1 1 0 0 1 1 1 0 NOA36 protein GST_C_3 PF14497.6 ORX71072.1 - 5.8e-12 45.7 0.0 8.9e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX71072.1 - 0.00049 20.3 0.0 0.0032 17.6 0.0 1.9 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71072.1 - 0.00053 20.3 0.1 0.0026 18.1 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ORX71072.1 - 0.0039 17.6 0.0 0.0069 16.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX71072.1 - 0.036 14.1 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CDC24_OB3 PF17244.2 ORX71073.1 - 1.5e-31 109.8 0.0 2.1e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 CDC24_OB1 PF17246.2 ORX71073.1 - 4.9e-06 26.7 0.0 9.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 1 RMI1_C PF16099.5 ORX71073.1 - 1.1e-05 25.3 0.0 4.9e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Rep_fac-A_C PF08646.10 ORX71073.1 - 0.0065 16.2 0.0 0.018 14.8 0.0 1.7 2 0 0 2 2 2 1 Replication factor-A C terminal domain CDC24_OB2 PF17245.2 ORX71073.1 - 0.037 14.6 0.0 0.12 13.0 0.0 1.8 1 1 0 1 1 1 0 Cell division control protein 24, OB domain 2 Peptidase_M36 PF02128.15 ORX71074.1 - 7.8e-154 512.3 2.4 1e-153 511.9 2.4 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX71074.1 - 1.1e-12 47.6 2.7 1.1e-12 47.6 2.7 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX71074.1 - 1.1e-05 25.4 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX71074.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain ABC_tran PF00005.27 ORX71075.1 - 8.9e-42 142.8 0.1 1.7e-19 70.7 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ORX71075.1 - 1.8e-21 75.9 6.5 9.8e-21 73.6 4.7 2.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ORX71075.1 - 6.3e-20 72.2 1.6 1.5e-07 31.5 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX71075.1 - 2.2e-08 34.9 1.3 0.041 14.4 0.1 3.6 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.19 ORX71075.1 - 6.2e-08 32.3 0.0 0.0071 15.8 0.1 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ORX71075.1 - 2.5e-07 30.8 0.0 0.019 14.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.6 ORX71075.1 - 4.4e-07 29.5 0.0 0.0079 15.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX71075.1 - 5.5e-07 30.1 0.0 0.029 14.8 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 ORX71075.1 - 5.6e-07 29.6 0.0 0.0082 15.9 0.0 2.9 2 2 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 ORX71075.1 - 9.9e-06 26.0 0.0 0.033 14.6 0.1 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ORX71075.1 - 1.2e-05 25.1 0.1 0.14 11.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ORX71075.1 - 1.2e-05 25.5 0.0 0.017 15.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 ORX71075.1 - 2.7e-05 24.2 0.2 0.31 11.0 0.2 3.3 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ORX71075.1 - 0.00012 22.6 0.0 0.46 11.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.6 ORX71075.1 - 0.00019 21.7 0.0 0.16 12.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 ORX71075.1 - 0.0002 21.0 0.0 0.071 12.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 ORX71075.1 - 0.0002 21.3 0.1 0.017 15.0 0.0 2.6 3 0 0 3 3 2 1 RsgA GTPase AAA_33 PF13671.6 ORX71075.1 - 0.00025 21.2 0.0 0.33 11.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_13 PF13166.6 ORX71075.1 - 0.00027 19.8 0.4 6.1 5.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ORX71075.1 - 0.00035 20.6 0.0 0.032 14.3 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 ORX71075.1 - 0.00067 19.4 0.3 0.38 10.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 ORX71075.1 - 0.0012 18.1 0.0 0.77 8.9 0.0 3.1 2 1 0 2 2 2 1 NB-ARC domain AAA_17 PF13207.6 ORX71075.1 - 0.0019 18.6 0.3 0.15 12.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 ORX71075.1 - 0.0021 18.3 0.0 3.3 7.9 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ORX71075.1 - 0.0024 18.3 0.3 1.5 9.3 0.0 3.3 3 0 0 3 3 3 1 RNA helicase G-alpha PF00503.20 ORX71075.1 - 0.0038 16.5 2.2 1.4 8.0 0.0 3.4 2 2 1 3 3 3 1 G-protein alpha subunit AAA_5 PF07728.14 ORX71075.1 - 0.004 17.2 0.1 0.93 9.5 0.1 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX71075.1 - 0.0049 16.4 0.1 0.17 11.4 0.0 2.7 3 0 0 3 3 3 1 P-loop containing dynein motor region T2SSE PF00437.20 ORX71075.1 - 0.013 14.6 0.0 0.39 9.7 0.0 2.7 3 1 0 3 3 3 0 Type II/IV secretion system protein PduV-EutP PF10662.9 ORX71075.1 - 0.018 14.8 0.5 6.7 6.5 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Pox_A32 PF04665.12 ORX71075.1 - 0.022 14.2 1.5 1.1 8.7 0.0 2.8 3 0 0 3 3 3 0 Poxvirus A32 protein Dynamin_N PF00350.23 ORX71075.1 - 0.028 14.5 2.3 16 5.5 0.0 3.8 2 1 1 3 3 3 0 Dynamin family DUF87 PF01935.17 ORX71075.1 - 0.029 14.5 0.7 8.4 6.4 0.0 3.1 3 1 0 3 3 2 0 Helicase HerA, central domain AAA_14 PF13173.6 ORX71075.1 - 0.034 14.2 0.0 5.1 7.1 0.0 3.1 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 ORX71075.1 - 0.041 13.8 0.1 3.2 7.6 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 ORX71075.1 - 0.043 14.1 0.0 5.7 7.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ORX71075.1 - 0.075 12.6 0.4 11 5.5 0.0 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 ORX71075.1 - 0.076 12.9 0.0 16 5.3 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MobB PF03205.14 ORX71075.1 - 0.1 12.5 0.2 6.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MarR_2 PF12802.7 ORX71075.1 - 0.16 11.9 0.0 0.43 10.5 0.0 1.7 1 0 0 1 1 1 0 MarR family KapB PF08810.10 ORX71075.1 - 0.16 12.2 1.0 0.9 9.7 0.0 2.3 2 0 0 2 2 2 0 Kinase associated protein B PH PF00169.29 ORX71076.1 - 0.00022 21.7 0.0 0.00068 20.1 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF1283 PF06932.11 ORX71076.1 - 0.23 11.7 1.8 0.53 10.5 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) Bromodomain PF00439.25 ORX71077.1 - 3.6e-19 68.6 0.0 6.2e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.17 ORX71077.1 - 1.5e-14 54.1 0.1 3.5e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 PWWP domain PolyG_pol PF01518.16 ORX71077.1 - 0.1 11.3 0.0 0.16 10.6 0.0 1.2 1 0 0 1 1 1 0 Sigma NS protein DEFB136 PF17333.2 ORX71077.1 - 0.11 12.5 0.3 0.11 12.5 0.3 2.1 2 0 0 2 2 2 0 Beta defensin 136 zf-HC5HC2H_2 PF13832.6 ORX71078.1 - 1.2e-31 109.1 5.5 1.2e-31 109.1 5.5 2.2 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ORX71078.1 - 2.1e-23 82.4 1.8 2.1e-23 82.4 1.8 3.1 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.6 ORX71078.1 - 3.7e-16 58.4 2.6 3.7e-16 58.4 2.6 3.2 3 0 0 3 3 3 2 PHD-finger PHD PF00628.29 ORX71078.1 - 1.4e-10 40.8 8.0 1.4e-10 40.8 8.0 3.3 3 1 0 3 3 3 2 PHD-finger EPL1 PF10513.9 ORX71078.1 - 4.5e-07 30.4 0.2 6.9e-07 29.8 0.2 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-PHD-like PF15446.6 ORX71078.1 - 0.013 15.2 6.1 0.013 15.2 6.1 2.9 3 1 0 3 3 3 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 ORX71078.1 - 0.016 15.1 2.8 0.016 15.1 2.8 3.3 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 ORX71078.1 - 0.02 14.8 6.1 0.02 14.8 6.1 3.6 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 UAA PF08449.11 ORX71080.1 - 6.4e-89 298.1 12.0 7.5e-89 297.9 12.0 1.0 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 ORX71080.1 - 3.9e-05 22.7 1.6 3.9e-05 22.7 1.6 1.9 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 ORX71080.1 - 0.00099 18.5 1.7 0.00099 18.5 1.7 2.4 3 0 0 3 3 3 2 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 ORX71080.1 - 0.015 14.5 0.9 0.015 14.5 0.9 2.2 2 0 0 2 2 2 0 Nucleotide-sugar transporter PUNUT PF16913.5 ORX71080.1 - 0.05 12.8 14.5 0.22 10.7 6.1 2.3 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport EamA PF00892.20 ORX71080.1 - 0.24 11.6 19.6 0.11 12.7 3.6 3.0 3 0 0 3 3 3 0 EamA-like transporter family SLC35F PF06027.12 ORX71080.1 - 1.8 8.0 13.6 8.5 5.8 13.6 2.0 1 1 0 1 1 1 0 Solute carrier family 35 TFIIA PF03153.13 ORX71081.1 - 4.4 7.2 22.4 8.3 6.3 22.4 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Aa_trans PF01490.18 ORX71084.1 - 4.1e-52 177.3 20.3 5.5e-52 176.8 20.3 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 ORX71084.1 - 0.02 13.7 15.7 0.029 13.2 15.7 1.2 1 0 0 1 1 1 0 Spore germination protein PBP1_TM PF14812.6 ORX71084.1 - 0.066 13.6 0.2 1.8 9.0 0.0 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RabGAP-TBC PF00566.18 ORX71085.1 - 6.7e-12 45.5 0.0 8.2e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ABC_tran PF00005.27 ORX71087.1 - 9.5e-54 181.6 0.0 2e-29 102.9 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX71087.1 - 7.3e-24 84.9 13.9 1.3e-23 84.1 13.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX71087.1 - 1.3e-10 41.1 0.2 0.0016 17.9 0.0 4.6 4 1 1 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX71087.1 - 1.3e-06 29.0 1.6 0.00044 20.8 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX71087.1 - 1.5e-06 27.9 0.3 0.02 14.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 ORX71087.1 - 8.2e-06 25.5 0.9 0.031 13.8 0.2 2.8 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX71087.1 - 1.2e-05 24.6 0.1 0.13 11.3 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ORX71087.1 - 1.2e-05 25.3 0.5 0.027 14.4 0.1 2.9 3 0 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX71087.1 - 2.8e-05 24.2 1.2 0.08 13.0 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 ORX71087.1 - 0.00051 19.4 0.4 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_21 PF13304.6 ORX71087.1 - 0.0042 16.9 4.3 0.079 12.8 0.1 3.2 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX71087.1 - 0.011 16.1 2.6 1.8 8.9 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 ORX71087.1 - 0.017 15.7 0.0 10 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ORX71087.1 - 0.026 14.6 6.9 0.23 11.5 0.2 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain Adeno_IVa2 PF02456.15 ORX71087.1 - 0.032 13.1 0.4 0.12 11.2 0.1 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_22 PF13401.6 ORX71087.1 - 0.042 14.1 6.4 1.9 8.7 0.7 3.1 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX71087.1 - 0.051 12.9 0.4 3 7.1 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.6 ORX71087.1 - 0.057 13.6 0.1 14 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 ORX71087.1 - 0.06 12.3 0.5 1.7 7.5 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_10 PF12846.7 ORX71087.1 - 0.063 12.2 1.7 5.5 5.8 0.0 2.6 3 0 0 3 3 3 0 AAA-like domain RNA_helicase PF00910.22 ORX71087.1 - 0.08 13.3 0.2 16 5.9 0.0 2.8 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 ORX71087.1 - 0.09 12.4 4.2 0.72 9.4 0.9 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 ORX71087.1 - 0.099 12.1 0.0 13 5.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 ORX71087.1 - 0.11 12.2 0.6 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ORX71087.1 - 0.12 12.5 4.0 0.38 10.8 0.4 2.4 2 0 0 2 2 2 0 Dynamin family AAA_30 PF13604.6 ORX71087.1 - 0.13 12.0 1.8 8.8 6.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 ORX71087.1 - 0.21 11.3 0.2 3.6 7.2 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 ORX71087.1 - 0.26 10.2 2.1 2.5 6.9 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 ORX71087.1 - 0.28 10.9 2.1 8.4 6.1 0.0 2.8 4 0 0 4 4 2 0 IstB-like ATP binding protein NACHT PF05729.12 ORX71087.1 - 2.1 8.2 4.1 9.6 6.1 0.5 3.1 3 0 0 3 3 3 0 NACHT domain ABC_ATPase PF09818.9 ORX71087.1 - 5.7 5.6 6.0 3.5 6.3 0.0 2.7 4 0 0 4 4 4 0 Predicted ATPase of the ABC class Peptidase_M36 PF02128.15 ORX71090.1 - 1.6e-154 514.5 3.2 2.1e-154 514.2 3.2 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX71090.1 - 3.1e-12 46.1 2.8 3.1e-12 46.1 2.8 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX71090.1 - 1.3e-05 25.1 0.1 3.3e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX71090.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain 7tm_1 PF00001.21 ORX71092.1 - 0.00045 19.6 17.3 0.00068 19.0 17.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Adipogenin PF15202.6 ORX71092.1 - 0.1 12.6 0.3 3.5 7.7 0.0 2.7 2 0 0 2 2 2 0 Adipogenin EF-hand_4 PF12763.7 ORX71093.1 - 3.4e-30 104.1 0.0 1.3e-18 66.8 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 ORX71093.1 - 9.9e-19 66.9 1.1 7e-11 41.8 0.1 2.8 2 1 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX71093.1 - 3.4e-15 55.4 6.7 2.5e-11 43.0 0.2 3.6 3 1 0 3 3 3 2 SH3 domain EF-hand_7 PF13499.6 ORX71093.1 - 2.6e-05 24.6 0.0 0.01 16.2 0.0 3.6 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 ORX71093.1 - 0.00078 18.8 0.0 0.021 14.4 0.0 2.9 2 0 0 2 2 2 1 EF hand SH3_2 PF07653.17 ORX71093.1 - 0.0009 18.9 0.1 0.26 11.0 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain Spc7 PF08317.11 ORX71093.1 - 0.013 14.4 20.0 0.071 12.0 3.5 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF5344 PF17279.2 ORX71093.1 - 0.029 15.0 1.8 0.42 11.2 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) DUF4391 PF14335.6 ORX71093.1 - 0.031 14.0 2.3 0.085 12.6 2.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Nup54 PF13874.6 ORX71093.1 - 0.6 10.2 15.9 0.055 13.6 5.5 2.6 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Mto2_bdg PF12808.7 ORX71093.1 - 1.5 9.1 6.7 0.19 12.0 1.1 2.6 3 0 0 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1664 PF07889.12 ORX71093.1 - 1.9 8.5 8.1 9.6 6.3 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ORX71093.1 - 2.1 8.7 5.4 12 6.2 0.1 3.5 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Vps53_N PF04100.12 ORX71093.1 - 7.7 5.4 8.6 0.34 9.8 2.0 1.9 2 0 0 2 2 2 0 Vps53-like, N-terminal Sec16_C PF12931.7 ORX71094.1 - 3.6e-10 40.0 0.1 1.9e-09 37.6 0.1 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 ORX71094.1 - 5e-06 27.1 14.7 0.23 12.4 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat TRAP_alpha PF03896.16 ORX71094.1 - 0.67 9.1 7.5 1.1 8.4 7.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 ORX71094.1 - 0.79 9.1 15.4 1.2 8.5 15.4 1.1 1 0 0 1 1 1 0 SDA1 Eaf7 PF07904.13 ORX71094.1 - 2.4 8.6 0.0 2.4 8.6 0.0 3.0 2 1 0 2 2 2 0 Chromatin modification-related protein EAF7 SpoIIIAH PF12685.7 ORX71094.1 - 3.7 7.3 9.3 4.6 7.0 7.1 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein FYDLN_acid PF09538.10 ORX71094.1 - 4.9 7.9 14.0 14 6.4 14.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF4744 PF15918.5 ORX71094.1 - 6.4 7.7 8.0 1.6 9.6 1.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4744) CDC45 PF02724.14 ORX71094.1 - 7.6 4.7 10.3 12 4.1 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ORX71094.1 - 8.2 6.2 12.3 15 5.3 12.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RTA1 PF04479.13 ORX71095.1 - 7e-21 74.8 0.3 7e-21 74.8 0.3 1.0 1 0 0 1 1 1 1 RTA1 like protein Peptidase_M16_C PF05193.21 ORX71096.1 - 1e-14 55.0 0.0 2.5e-08 34.1 0.0 3.6 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX71096.1 - 6.1e-11 42.5 0.0 1.7e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M36 PF02128.15 ORX71097.1 - 5.2e-153 509.6 3.6 6.8e-153 509.2 3.6 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX71097.1 - 3.1e-12 46.1 2.8 3.1e-12 46.1 2.8 1.9 2 0 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 ORX71097.1 - 0.00028 20.8 0.1 0.00072 19.5 0.0 1.7 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain FAD_binding_9 PF08021.11 ORX71097.1 - 0.096 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain CDC24_OB3 PF17244.2 ORX71098.1 - 3.1e-30 105.6 0.0 4.2e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 CDC24_OB1 PF17246.2 ORX71098.1 - 4.9e-06 26.7 0.0 9.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 1 RMI1_C PF16099.5 ORX71098.1 - 1.2e-05 25.1 0.1 5.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Rep_fac-A_C PF08646.10 ORX71098.1 - 0.019 14.7 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 Replication factor-A C terminal domain CDC24_OB2 PF17245.2 ORX71098.1 - 0.067 13.8 0.0 0.22 12.1 0.0 1.8 1 1 0 1 1 1 0 Cell division control protein 24, OB domain 2 GST_C_3 PF14497.6 ORX71099.1 - 2.2e-10 40.6 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX71099.1 - 1e-05 25.6 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX71099.1 - 0.001 19.1 0.0 0.0028 17.6 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71099.1 - 0.001 19.4 0.0 0.0028 18.0 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ORX71099.1 - 0.0013 19.1 0.0 0.0022 18.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71099.1 - 0.048 14.0 0.0 0.076 13.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX71100.1 - 7.8e-11 42.0 0.0 1.2e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX71100.1 - 2e-06 27.9 0.0 8.7e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71100.1 - 7.7e-06 26.2 0.0 2e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ORX71100.1 - 2.3e-05 24.7 0.0 3.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 ORX71100.1 - 0.015 15.6 0.1 0.41 11.0 0.1 2.1 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein GST_N_2 PF13409.6 ORX71100.1 - 0.18 12.1 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain NAD_binding_6 PF08030.12 ORX71102.1 - 3e-22 79.4 0.0 5.5e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX71102.1 - 6.3e-15 55.2 0.0 5e-14 52.3 0.0 2.1 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 ORX71102.1 - 1e-13 51.5 10.9 1e-13 51.5 10.9 2.0 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX71102.1 - 0.018 15.7 0.0 0.3 11.8 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Transglut_N PF00868.20 ORX71103.1 - 0.041 14.2 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase family E1_DerP2_DerF2 PF02221.15 ORX71103.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 ML domain QRPTase_C PF01729.19 ORX71105.1 - 7.1e-58 195.1 0.4 8.5e-58 194.9 0.4 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 ORX71105.1 - 2.8e-18 65.7 0.0 1.7e-17 63.3 0.0 2.2 2 1 1 3 3 3 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 ORX71105.1 - 0.01 15.2 0.2 0.017 14.5 0.2 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase DUF2229 PF09989.9 ORX71105.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) SF3b10 PF07189.11 ORX71106.1 - 2.2e-29 101.4 0.1 2.4e-29 101.2 0.1 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) BTB PF00651.31 ORX71108.1 - 2.9e-17 62.9 0.0 1.9e-16 60.3 0.0 2.3 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.15 ORX71108.1 - 7e-17 61.4 6.7 7.2e-12 45.3 2.1 3.2 3 0 0 3 3 3 2 BTB And C-terminal Kelch APH PF01636.23 ORX71109.1 - 3.5e-42 145.0 0.0 4.6e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX71109.1 - 1e-05 25.0 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 ORX71109.1 - 0.00016 21.0 0.0 0.019 14.2 0.0 2.3 2 1 0 2 2 2 2 Fructosamine kinase RIO1 PF01163.22 ORX71109.1 - 0.00027 20.6 0.0 0.41 10.2 0.0 2.4 2 0 0 2 2 2 2 RIO1 family DUF1679 PF07914.11 ORX71109.1 - 0.0017 17.3 0.0 0.0047 15.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 ORX71109.1 - 0.0038 16.8 0.0 0.0063 16.1 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 ORX71109.1 - 0.014 14.8 0.0 0.67 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain LRR_4 PF12799.7 ORX71110.1 - 0.082 13.4 0.8 31 5.2 0.1 4.3 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 ORX71110.1 - 0.32 11.7 3.6 0.55 11.0 0.9 2.9 2 0 0 2 2 2 0 Leucine Rich Repeat SRP-alpha_N PF04086.13 ORX71110.1 - 1.2 9.0 12.5 1.8 8.4 12.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal zf-C3HC4_3 PF13920.6 ORX71110.1 - 2.2 8.2 5.8 0.15 11.9 0.4 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1682 PF07946.14 ORX71110.1 - 4.4 6.4 20.4 8.2 5.5 20.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CDC45 PF02724.14 ORX71110.1 - 7.7 4.7 9.5 4.1 5.6 7.8 1.4 2 0 0 2 2 2 0 CDC45-like protein PGA2 PF07543.12 ORX71110.1 - 7.8 6.5 14.9 16 5.5 14.9 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 SH3_9 PF14604.6 ORX71111.1 - 5e-08 32.7 0.0 9.1e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX71111.1 - 2.8e-07 30.0 0.0 5.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX71111.1 - 0.0061 16.2 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PBD PF00786.28 ORX71111.1 - 0.011 16.0 1.3 0.46 10.9 0.2 2.6 2 0 0 2 2 2 0 P21-Rho-binding domain Glyco_hydro_47 PF01532.20 ORX71112.1 - 3.1e-134 448.3 7.0 4.4e-88 296.2 0.2 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 ORX71112.1 - 0.084 12.1 0.3 3.9 6.6 0.1 2.4 2 1 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Rer1 PF03248.13 ORX71113.1 - 4.1e-77 257.7 2.7 4.7e-77 257.5 2.7 1.0 1 0 0 1 1 1 1 Rer1 family DUF2244 PF10003.9 ORX71113.1 - 1.2 8.8 6.7 6.2 6.5 1.0 2.2 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) DUF2207 PF09972.9 ORX71113.1 - 1.5 7.5 4.9 0.71 8.6 0.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) tRNA-synt_2b PF00587.25 ORX71114.1 - 1.7e-32 112.8 0.0 3.2e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX71114.1 - 4.7e-20 71.5 0.2 9e-20 70.6 0.2 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 ORX71114.1 - 1.9e-12 47.0 0.0 4.9e-12 45.7 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain zf-RVT PF13966.6 ORX71117.1 - 0.0039 17.9 0.0 0.011 16.4 0.0 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase IL5 PF02025.15 ORX71118.1 - 0.23 11.7 0.0 0.25 11.6 0.0 1.1 1 0 0 1 1 1 0 Interleukin 5 zf-RVT PF13966.6 ORX71120.1 - 0.004 17.8 0.0 0.012 16.3 0.0 1.9 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase ATP1G1_PLM_MAT8 PF02038.16 ORX71121.1 - 0.071 12.6 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Cu-oxidase PF00394.22 ORX71126.1 - 0.09 12.9 0.1 0.28 11.3 0.1 1.7 1 1 1 2 2 2 0 Multicopper oxidase Phage_holin_2_4 PF16082.5 ORX71128.1 - 6.7 6.5 7.1 1.1e+02 2.6 7.1 2.1 1 1 0 1 1 1 0 Bacteriophage holin family, superfamily II-like MFS_1 PF07690.16 ORX71130.1 - 8.1e-52 176.3 53.8 1.9e-51 175.1 53.8 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX71130.1 - 8.3e-19 67.4 27.1 1.1e-18 67.0 27.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX71130.1 - 5.6e-13 48.6 38.3 9e-13 47.9 10.0 3.0 3 1 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 ORX71130.1 - 0.0016 16.9 3.5 0.0016 16.9 3.5 2.4 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family PufQ PF05398.11 ORX71130.1 - 1.1 9.4 5.4 0.24 11.5 0.5 2.5 3 0 0 3 3 3 0 PufQ cytochrome subunit Mago-bind PF09282.10 ORX71133.1 - 1.7e-13 50.2 1.0 1.7e-13 50.2 1.0 1.6 2 0 0 2 2 2 1 Mago binding Androgen_recep PF02166.16 ORX71133.1 - 0.023 13.6 0.3 0.03 13.2 0.3 1.2 1 0 0 1 1 1 0 Androgen receptor Cu-oxidase_2 PF07731.14 ORX71135.1 - 2.7e-36 124.3 5.8 7.7e-34 116.4 0.1 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX71135.1 - 2.2e-34 118.0 3.8 1.5e-32 112.1 1.0 3.5 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX71135.1 - 2.6e-30 105.7 0.2 2.3e-28 99.3 0.0 3.0 3 0 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 ORX71135.1 - 0.12 12.5 0.0 7.4 6.7 0.0 2.8 2 0 0 2 2 2 0 Cupredoxin-like domain TspO_MBR PF03073.15 ORX71137.1 - 3.5e-13 49.8 7.9 4.2e-13 49.5 7.9 1.1 1 0 0 1 1 1 1 TspO/MBR family Pkinase PF00069.25 ORX71138.1 - 8.9e-29 100.6 0.0 1.3e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71138.1 - 9.8e-15 54.5 0.0 4.3e-13 49.1 0.0 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71138.1 - 9.3e-06 25.2 0.0 2.9e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX71138.1 - 0.025 13.9 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX71138.1 - 0.092 12.6 0.2 0.092 12.6 0.2 2.4 2 1 0 3 3 3 0 Phosphotransferase enzyme family TetR_C_20 PF17925.1 ORX71138.1 - 0.19 12.1 1.4 7.2 7.0 0.0 2.6 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Rotamase PF00639.21 ORX71139.1 - 2.1e-27 95.9 0.0 2.6e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ORX71139.1 - 3.1e-22 79.3 0.0 4.2e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ORX71139.1 - 2.1e-07 31.8 0.0 2.7e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 ORX71139.1 - 1.3e-06 28.4 0.6 7.4e-06 26.0 0.2 2.2 2 0 0 2 2 2 1 WW domain Glyco_transf_43 PF03360.16 ORX71139.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 43 THDPS_N_2 PF14805.6 ORX71139.1 - 0.14 12.4 0.6 0.31 11.3 0.6 1.7 1 1 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal PALP PF00291.25 ORX71140.1 - 1e-65 222.1 0.1 1.2e-65 221.8 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AMP-binding PF00501.28 ORX71141.1 - 4.2e-29 101.4 1.0 3.7e-26 91.7 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ORX71141.1 - 0.015 16.2 0.2 0.039 14.9 0.2 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain PITH PF06201.13 ORX71142.1 - 4.1e-26 92.0 2.2 2e-24 86.5 2.2 2.2 1 1 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 ORX71142.1 - 8.2e-20 70.7 0.0 1.4e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX71142.1 - 0.001 19.5 0.8 0.11 12.9 0.1 3.2 2 2 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.16 ORX71142.1 - 0.004 16.1 0.0 0.006 15.6 0.0 1.2 1 0 0 1 1 1 1 Phosducin DIM1 PF02966.16 ORX71142.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Mitosis protein DIM1 TraF PF13728.6 ORX71142.1 - 0.13 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Acetyltransf_13 PF13880.6 ORX71143.1 - 1.3e-23 82.8 0.0 2.2e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 ORX71143.1 - 5.6e-15 54.9 2.1 7.3e-15 54.5 1.2 1.7 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 ORX71143.1 - 0.0013 19.1 0.1 0.0027 18.1 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Coronavirus_5 PF05528.11 ORX71143.1 - 0.0025 17.7 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 Coronavirus gene 5 protein Acetyltransf_1 PF00583.25 ORX71143.1 - 0.026 14.7 0.2 0.056 13.7 0.1 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family P2 PF07194.11 ORX71144.1 - 0.076 13.1 0.1 0.094 12.8 0.1 1.4 1 1 0 1 1 1 0 P2 response regulator binding domain FliS PF02561.14 ORX71145.1 - 0.057 13.7 0.0 0.52 10.6 0.0 2.5 2 0 0 2 2 2 0 Flagellar protein FliS Med21 PF11221.8 ORX71146.1 - 3.2e-29 102.0 6.4 3.2e-29 102.0 6.4 1.5 2 0 0 2 2 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 ORX71146.1 - 0.0042 17.1 1.4 0.016 15.3 1.4 2.2 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF948 PF06103.11 ORX71146.1 - 0.0043 17.3 1.7 1.8 8.8 0.4 2.4 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF948) GAS PF13851.6 ORX71146.1 - 0.01 15.2 1.4 0.018 14.4 1.3 1.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med30 PF11315.8 ORX71146.1 - 0.018 15.2 3.6 0.27 11.4 1.6 2.2 1 1 1 2 2 2 0 Mediator complex subunit 30 Lipoprotein_6 PF01441.19 ORX71146.1 - 0.024 14.7 2.4 0.065 13.2 2.4 1.9 1 1 0 1 1 1 0 Lipoprotein Syntaxin-6_N PF09177.11 ORX71146.1 - 0.029 14.9 0.3 0.058 14.0 0.3 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF4407 PF14362.6 ORX71146.1 - 0.031 13.6 2.0 0.034 13.5 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 ORX71146.1 - 0.033 14.6 4.7 0.12 12.8 2.5 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DLP_helical PF18709.1 ORX71146.1 - 0.043 13.0 2.8 0.058 12.6 2.8 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain ISG65-75 PF11727.8 ORX71146.1 - 0.05 12.8 2.3 0.069 12.4 2.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein SabA_adhesion PF18304.1 ORX71146.1 - 0.055 12.7 1.1 0.25 10.5 0.6 1.7 1 1 1 2 2 2 0 SabA N-terminal extracellular adhesion domain DUF848 PF05852.11 ORX71146.1 - 0.063 13.4 2.5 0.21 11.7 1.7 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Golgin_A5 PF09787.9 ORX71146.1 - 0.067 12.6 2.3 1.2 8.5 1.8 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 HisKA_3 PF07730.13 ORX71146.1 - 0.078 13.5 1.2 0.13 12.8 0.4 1.8 2 0 0 2 2 2 0 Histidine kinase BAR PF03114.18 ORX71146.1 - 0.22 11.1 5.4 0.26 10.9 5.4 1.3 1 1 0 1 1 1 0 BAR domain PhoU PF01895.19 ORX71146.1 - 0.29 11.6 5.3 25 5.4 5.2 2.9 2 1 0 2 2 2 0 PhoU domain CorA PF01544.18 ORX71146.1 - 0.47 9.7 3.3 0.86 8.9 3.3 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF730 PF05325.11 ORX71146.1 - 0.64 10.1 2.6 0.44 10.6 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF730) HisKA PF00512.25 ORX71146.1 - 1.7 8.7 4.4 24 5.1 1.3 2.6 2 1 1 3 3 3 0 His Kinase A (phospho-acceptor) domain TB2_DP1_HVA22 PF03134.19 ORX71147.1 - 1.6e-12 47.2 0.6 2.7e-12 46.4 0.6 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family CHRD PF07452.12 ORX71147.1 - 0.079 13.9 0.0 0.12 13.3 0.0 1.3 1 0 0 1 1 1 0 CHRD domain CsiD PF08943.10 ORX71147.1 - 0.14 11.2 0.2 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 CsiD DBR1 PF05011.13 ORX71148.1 - 2.9e-32 112.0 0.0 5.2e-31 107.9 0.0 2.1 1 1 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 ORX71148.1 - 1.8e-07 31.9 0.1 2.9e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_M74 PF03411.13 ORX71148.1 - 0.056 13.0 0.1 0.095 12.2 0.1 1.2 1 0 0 1 1 1 0 Penicillin-insensitive murein endopeptidase Metallophos_2 PF12850.7 ORX71148.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain HMG_box_2 PF09011.10 ORX71151.1 - 4.6e-11 43.2 3.7 1.4e-10 41.6 3.7 1.8 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 ORX71151.1 - 1.5e-09 38.1 3.4 3.2e-09 37.1 3.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box WYL_3 PF18488.1 ORX71151.1 - 0.034 14.5 1.7 0.062 13.7 1.7 1.3 1 0 0 1 1 1 0 WYL domain Peptidase_S10 PF00450.22 ORX71153.1 - 1.4e-76 258.6 0.0 2.1e-76 258.0 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Mucin PF01456.17 ORX71154.1 - 0.00056 19.9 0.9 0.0009 19.2 0.9 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein Zip PF02535.22 ORX71154.1 - 0.077 12.2 1.1 0.1 11.8 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SpoIIIAH PF12685.7 ORX71154.1 - 0.1 12.4 8.6 0.16 11.8 8.6 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein V_ATPase_I PF01496.19 ORX71154.1 - 0.32 8.9 0.7 0.41 8.5 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ORX71154.1 - 0.51 9.0 7.0 0.71 8.6 7.0 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ORX71154.1 - 1 8.3 5.1 1.3 8.0 5.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 ORX71154.1 - 2.2 6.9 12.1 3 6.5 12.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4551 PF15087.6 ORX71154.1 - 3.6 6.3 4.6 4.6 5.9 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Tim54 PF11711.8 ORX71154.1 - 6.3 5.5 7.0 10 4.8 7.0 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_Ag35 PF03286.14 ORX71154.1 - 6.6 6.5 20.4 11 5.8 20.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NTF2 PF02136.20 ORX71156.1 - 8.2e-34 116.8 0.3 9.1e-34 116.6 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 ORX71156.1 - 0.052 13.5 0.0 0.057 13.4 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 DUF3089 PF11288.8 ORX71156.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) AAA_12 PF13087.6 ORX71157.1 - 4.1e-57 193.0 0.0 6.3e-57 192.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX71157.1 - 5.8e-25 88.5 1.7 1.1e-18 68.0 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 ORX71157.1 - 3.4e-09 36.8 0.0 1e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 ORX71157.1 - 5e-07 29.6 0.4 1.9e-06 27.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX71157.1 - 6.3e-06 26.6 0.1 1.6e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ORX71157.1 - 0.00032 20.1 0.3 0.0056 16.0 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 ORX71157.1 - 0.00044 20.1 0.0 0.62 9.8 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 ORX71157.1 - 0.006 16.6 0.1 0.019 15.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase PF06745.13 ORX71157.1 - 0.015 14.7 0.0 0.28 10.5 0.0 2.2 2 0 0 2 2 2 0 KaiC ResIII PF04851.15 ORX71157.1 - 0.038 14.0 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX71157.1 - 0.088 13.1 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX71157.1 - 0.098 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 ORX71159.1 - 7.7e-64 215.6 0.2 5.9e-61 206.1 0.2 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.13 ORX71159.1 - 2.9e-16 59.5 13.3 2.9e-16 59.5 13.3 4.6 6 0 0 6 6 6 1 HSA Bromodomain PF00439.25 ORX71159.1 - 1.8e-14 53.5 0.3 8.3e-14 51.4 0.2 2.1 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.31 ORX71159.1 - 6.8e-12 45.7 2.7 5e-11 42.9 0.1 3.6 3 1 0 3 3 3 1 Helicase conserved C-terminal domain QLQ PF08880.11 ORX71159.1 - 1.1e-06 28.2 2.4 1.1e-06 28.2 2.4 2.5 3 0 0 3 3 3 1 QLQ ResIII PF04851.15 ORX71159.1 - 1.7e-06 28.2 0.3 0.11 12.4 0.0 3.3 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX71159.1 - 0.021 14.0 0.0 0.068 12.3 0.0 1.9 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 DUF3881 PF12997.7 ORX71159.1 - 1.7 7.9 4.4 0.82 8.9 0.8 2.1 1 1 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) Aldedh PF00171.22 ORX71160.1 - 3.8e-77 259.8 0.8 9.2e-53 179.4 0.0 4.1 3 1 1 4 4 4 3 Aldehyde dehydrogenase family Nucleoporin_C PF03177.14 ORX71161.1 - 8.8e-56 189.9 0.0 3.6e-41 141.6 0.0 2.7 2 1 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Orbi_NS1 PF01718.16 ORX71161.1 - 0.11 10.9 0.0 0.19 10.2 0.0 1.2 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein Nucleoporin_N PF08801.11 ORX71162.1 - 1.7e-09 36.9 0.0 2.4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like DGF-1_C PF11040.8 ORX71162.1 - 0.045 13.7 6.1 0.21 11.6 0.9 2.5 1 1 1 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Hist_deacetyl PF00850.19 ORX71163.1 - 3.3e-52 177.9 0.7 8.9e-49 166.6 0.1 2.1 1 1 0 2 2 2 2 Histone deacetylase domain adh_short PF00106.25 ORX71164.1 - 1.3e-39 135.7 1.3 1.6e-39 135.4 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX71164.1 - 1.2e-30 106.8 0.7 1.5e-30 106.5 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX71164.1 - 6.9e-08 32.6 0.1 1.5e-07 31.6 0.1 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX71164.1 - 0.00081 18.9 0.2 0.021 14.3 0.0 2.1 1 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 ORX71164.1 - 0.033 14.1 0.1 0.22 11.4 0.0 2.1 2 1 0 2 2 2 0 YjeF-related protein N-terminus IMPa_N_2 PF18650.1 ORX71164.1 - 0.036 13.3 0.1 0.063 12.5 0.1 1.4 1 0 0 1 1 1 0 Immunomodulating metalloprotease N-terminal domain Phage_GP20 PF06810.11 ORX71164.1 - 0.046 13.5 0.6 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 PP_kinase_C_1 PF17941.1 ORX71164.1 - 0.094 12.3 0.2 0.26 10.8 0.2 1.8 1 1 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 DHBP_synthase PF00926.19 ORX71165.1 - 2.8e-84 281.5 0.0 3.1e-84 281.3 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase TAL_FSA PF00923.19 ORX71166.1 - 1.7e-100 336.1 1.0 1.9e-100 335.9 1.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase APC_rep PF18797.1 ORX71166.1 - 0.14 13.1 0.0 8.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Adenomatous polyposis coli (APC) repeat 6PGD PF00393.19 ORX71167.1 - 2.2e-114 381.8 0.0 4.4e-114 380.7 0.0 1.5 1 1 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ORX71167.1 - 3.8e-52 176.6 0.0 5.5e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ORX71167.1 - 0.06 13.4 0.2 0.44 10.6 0.1 2.3 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Ub-Mut7C PF14451.6 ORX71167.1 - 0.087 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Mut7-C ubiquitin 2-Hacid_dh_C PF02826.19 ORX71167.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ORX71167.1 - 0.16 12.6 0.1 0.31 11.6 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent FA_hydroxylase PF04116.13 ORX71168.1 - 2.1e-14 54.0 26.9 2.4e-14 53.8 22.5 2.7 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Yos1 PF08571.10 ORX71169.1 - 1.2e-29 102.4 1.6 1.3e-29 102.2 1.6 1.0 1 0 0 1 1 1 1 Yos1-like Mito_carr PF00153.27 ORX71170.1 - 1.1e-51 172.7 2.7 4.4e-20 71.4 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF3759 PF12585.8 ORX71171.1 - 8.2e-15 54.6 1.1 1.5e-14 53.8 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) eIF-3c_N PF05470.12 ORX71172.1 - 3.3e-167 557.4 25.2 7e-136 454.0 10.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 ORX71172.1 - 8.3e-11 42.3 0.2 1.2e-09 38.7 0.0 2.9 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 ORX71172.1 - 0.032 14.3 1.2 0.79 10.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SMYLE_N PF18615.1 ORX71172.1 - 0.17 11.5 0.0 0.17 11.5 0.0 2.5 3 1 1 4 4 4 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF4375 PF14300.6 ORX71172.1 - 6.1 7.1 6.1 35 4.7 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4375) CI-B14_5a PF07347.12 ORX71173.1 - 0.00055 19.8 1.9 0.00055 19.8 1.9 2.1 1 1 1 2 2 2 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) FAD_binding_3 PF01494.19 ORX71174.1 - 4.4e-22 78.8 0.0 3.6e-21 75.8 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX71174.1 - 1.1e-05 25.3 0.0 2.7e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX71174.1 - 1.1e-05 25.6 0.0 3.8e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 ORX71174.1 - 1.1e-05 24.6 0.1 0.00045 19.4 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox PF00070.27 ORX71174.1 - 0.0028 18.2 0.1 0.024 15.2 0.0 2.6 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX71174.1 - 0.0054 16.0 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX71174.1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 ORX71174.1 - 0.021 14.7 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 ORX71174.1 - 0.051 12.3 0.0 0.13 11.0 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein ApbA PF02558.16 ORX71174.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 ORX71174.1 - 0.12 11.7 0.1 0.8 9.0 0.0 2.5 3 1 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Glyco_hydro_35 PF01301.19 ORX71176.1 - 3.8e-31 108.9 0.1 6e-31 108.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 ORX71176.1 - 4.7e-08 33.6 0.0 0.01 16.4 0.0 2.5 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain Glyco_hydro_42 PF02449.15 ORX71176.1 - 4.1e-06 26.4 0.1 9e-06 25.3 0.0 1.5 2 0 0 2 2 2 1 Beta-galactosidase Cellulase PF00150.18 ORX71176.1 - 0.00015 21.3 0.9 0.00038 20.0 0.0 1.9 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) HgmA PF04209.13 ORX71177.1 - 5.7e-202 671.0 0.1 6.5e-202 670.9 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase zf-LITAF-like PF10601.9 ORX71178.1 - 1.1e-11 44.8 0.1 1.9e-11 44.1 0.1 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain SOBP PF15279.6 ORX71178.1 - 0.059 14.0 8.9 0.068 13.8 8.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Sgf11 PF08209.11 ORX71178.1 - 0.062 12.9 0.7 0.062 12.9 0.7 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Ogr_Delta PF04606.12 ORX71178.1 - 0.33 11.0 2.5 3.8 7.6 0.3 2.7 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Macoilin PF09726.9 ORX71178.1 - 3.1 6.2 16.8 3.6 6.0 16.8 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ORX71178.1 - 3.2 6.4 18.3 4.3 6.0 18.3 1.3 1 0 0 1 1 1 0 Presenilin zf-ribbon_3 PF13248.6 ORX71178.1 - 4.6 6.8 6.7 3.8 7.0 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Apt1 PF10351.9 ORX71178.1 - 9.2 5.0 19.9 12 4.6 19.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CxC1 PF18802.1 ORX71179.1 - 0.042 14.0 0.0 0.073 13.2 0.0 1.5 1 1 0 1 1 1 0 CxC1 like cysteine cluster associated with KDZ transposases RRM_1 PF00076.22 ORX71180.1 - 9.8e-19 67.0 0.0 1.4e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3602 PF12223.8 ORX71180.1 - 0.15 12.6 2.7 0.18 12.5 1.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3602) Pkinase PF00069.25 ORX71181.1 - 2.6e-24 86.0 0.0 3.6e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71181.1 - 8.2e-09 35.1 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX71181.1 - 4.8e-08 32.2 0.9 5.7e-08 32.0 0.1 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX71181.1 - 0.0034 17.4 0.0 1.9 8.3 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family WD40 PF00400.32 ORX71182.1 - 8.7e-32 108.7 24.3 1.8e-06 28.5 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat NLE PF08154.12 ORX71182.1 - 1.6e-21 76.6 0.0 2.9e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 ORX71182.1 - 5.6e-07 29.8 2.8 0.00044 20.5 0.1 4.4 1 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX71182.1 - 0.00025 19.8 5.6 0.2 10.2 0.0 4.2 1 1 3 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX71182.1 - 0.00051 19.1 0.1 0.92 8.4 0.0 2.7 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 ORX71182.1 - 0.0029 17.6 0.1 4.5 7.3 0.0 3.6 4 1 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region LEA_2 PF03168.13 ORX71183.1 - 3.1e-05 24.4 0.0 4.9e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 Late embryogenesis abundant protein DUF1356 PF07092.12 ORX71183.1 - 0.012 14.9 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) SNF2_N PF00176.23 ORX71185.1 - 3.2e-24 85.3 0.0 4.2e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX71187.1 - 7.6e-18 64.9 0.0 1.8e-17 63.7 0.0 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ORX71187.1 - 0.014 14.6 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Ribosomal_L35Ae PF01247.18 ORX71188.1 - 5.3e-43 145.1 0.2 5.9e-43 145.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae Tetraspanin PF00335.20 ORX71189.1 - 1.2e-10 41.5 2.7 1.9e-10 40.9 2.7 1.3 1 0 0 1 1 1 1 Tetraspanin family Rhomboid PF01694.22 ORX71189.1 - 0.0096 15.9 2.5 0.0096 15.9 2.5 1.6 2 0 0 2 2 2 1 Rhomboid family PIG-U PF06728.13 ORX71189.1 - 0.043 12.9 2.0 0.066 12.2 2.0 1.3 1 0 0 1 1 1 0 GPI transamidase subunit PIG-U BsuPI PF12690.7 ORX71189.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Mfa1 PF17445.2 ORX71189.1 - 0.2 11.7 1.8 0.3 11.1 0.1 2.0 3 0 0 3 3 3 0 Mating factor A1 DUF4064 PF13273.6 ORX71189.1 - 0.27 11.5 2.9 0.27 11.5 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF308 PF03729.13 ORX71189.1 - 0.58 10.5 8.3 0.9 9.9 3.2 2.6 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) DUF981 PF06168.11 ORX71189.1 - 3.5 7.5 8.7 2.5 8.0 2.5 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF981) zf-RING_2 PF13639.6 ORX71190.1 - 7.9e-13 48.5 12.1 1.2e-12 48.0 12.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX71190.1 - 1.3e-10 41.4 9.2 2.8e-10 40.3 9.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX71190.1 - 6.7e-10 38.6 11.3 1.1e-09 38.0 11.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX71190.1 - 1.7e-08 34.1 5.9 1.7e-08 34.1 5.9 1.7 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX71190.1 - 7.3e-07 28.9 11.9 1.1e-06 28.3 11.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX71190.1 - 1.8e-06 27.9 4.7 1.1e-05 25.4 6.1 1.7 2 1 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX71190.1 - 1.9e-06 27.8 5.3 1.9e-06 27.8 5.3 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX71190.1 - 3e-05 23.8 8.7 4.3e-05 23.3 8.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX71190.1 - 0.00012 21.9 10.8 0.00019 21.3 10.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX71190.1 - 0.00035 20.4 11.4 0.0026 17.6 10.6 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 ORX71190.1 - 0.0037 17.2 7.0 0.062 13.2 3.7 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_10 PF16685.5 ORX71190.1 - 0.005 16.9 5.4 0.0076 16.4 5.4 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 Zn_ribbon_17 PF17120.5 ORX71190.1 - 0.012 15.2 6.9 0.022 14.4 6.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX71190.1 - 0.018 15.1 8.5 0.058 13.5 8.5 1.9 1 1 0 1 1 1 0 RING-variant domain U-box PF04564.15 ORX71190.1 - 0.024 14.8 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 U-box domain zf-HC5HC2H PF13771.6 ORX71190.1 - 0.2 11.9 5.3 0.15 12.3 3.5 1.7 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX71190.1 - 0.21 11.7 5.0 0.13 12.5 3.0 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 ORX71190.1 - 0.5 10.2 8.5 0.94 9.3 8.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain UBZ_FAAP20 PF15750.5 ORX71190.1 - 0.94 9.5 5.7 6.8 6.7 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-P11 PF03854.14 ORX71190.1 - 1 9.0 10.6 2.9 7.6 10.6 1.8 1 1 0 1 1 1 0 P-11 zinc finger FANCL_C PF11793.8 ORX71190.1 - 1.1 9.4 9.6 17 5.7 9.6 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain Rad50_zn_hook PF04423.14 ORX71190.1 - 1.4 8.8 5.9 0.38 10.6 1.1 2.3 2 1 0 2 2 2 0 Rad50 zinc hook motif zf-C3H2C3 PF17122.5 ORX71190.1 - 4 7.6 9.0 10 6.3 9.0 1.8 1 1 0 1 1 1 0 Zinc-finger DEAD PF00270.29 ORX71191.1 - 6.2e-37 127.0 0.0 1.1e-36 126.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX71191.1 - 1.5e-10 41.4 1.1 2.6e-09 37.4 0.6 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ORX71191.1 - 0.0027 17.1 0.1 0.0054 16.1 0.1 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit WD40 PF00400.32 ORX71192.1 - 4.9e-12 46.2 8.7 0.016 16.0 0.1 6.2 6 1 0 6 6 6 3 WD domain, G-beta repeat DUF5423 PF17461.2 ORX71192.1 - 0.1 11.4 1.6 0.17 10.7 1.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) WD40_3 PF15911.5 ORX71192.1 - 0.12 12.4 0.0 6.2 6.9 0.0 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat AA_permease_2 PF13520.6 ORX71193.1 - 8.8e-33 113.8 23.4 4.4e-13 48.9 8.5 3.1 2 1 1 3 3 3 3 Amino acid permease IDO PF01231.18 ORX71194.1 - 1.9e-120 402.6 0.2 7.5e-115 384.2 0.0 2.0 1 1 1 2 2 2 2 Indoleamine 2,3-dioxygenase Trp_dioxygenase PF03301.13 ORX71194.1 - 0.02 14.3 0.1 0.04 13.2 0.1 1.5 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase AA_permease_2 PF13520.6 ORX71195.1 - 1e-39 136.6 26.9 7.6e-38 130.4 14.7 2.5 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 ORX71195.1 - 5.5e-08 31.8 14.9 5.5e-08 31.8 14.9 3.0 2 1 0 2 2 2 1 Amino acid permease zf-4CXXC_R1 PF10497.9 ORX71196.1 - 5e-28 97.2 12.6 7.9e-28 96.6 12.6 1.3 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 SSXRD PF09514.10 ORX71196.1 - 0.058 13.0 0.0 0.058 13.0 0.0 2.7 2 0 0 2 2 2 0 SSXRD motif Vps23_core PF09454.10 ORX71197.1 - 3e-18 65.5 0.0 5.6e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Vps23 core domain UEV PF05743.13 ORX71197.1 - 6.9e-10 38.8 0.0 1.3e-08 34.7 0.0 2.5 2 1 0 2 2 2 1 UEV domain PspA_IM30 PF04012.12 ORX71197.1 - 0.0032 17.1 2.6 0.0065 16.1 2.6 1.4 1 0 0 1 1 1 1 PspA/IM30 family TelA PF05816.11 ORX71197.1 - 0.0093 15.1 1.1 0.013 14.6 1.1 1.1 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DUF5082 PF16888.5 ORX71197.1 - 0.018 15.3 0.4 0.037 14.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF4653 PF15546.6 ORX71197.1 - 0.026 14.2 2.8 0.057 13.0 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) Med15_fungi PF05397.12 ORX71198.1 - 6.6e-11 42.5 1.7 6.6e-11 42.5 1.7 4.2 4 1 0 4 4 4 1 Mediator complex subunit 15 KIX_2 PF16987.5 ORX71198.1 - 5e-08 32.8 0.2 2.3e-07 30.7 0.2 2.3 1 0 0 1 1 1 1 KIX domain Pyridoxal_deC PF00282.19 ORX71199.1 - 2.6e-54 184.4 0.0 3.4e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF5600 PF18150.1 ORX71200.1 - 8.2e-35 119.6 0.1 1.5e-34 118.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Dynamin_N PF00350.23 ORX71200.1 - 6.2e-15 55.7 0.0 2.8e-13 50.3 0.0 2.3 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 ORX71200.1 - 2e-09 37.2 0.0 5.6e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 N-terminal EH-domain containing protein EF-hand_4 PF12763.7 ORX71200.1 - 1.3e-07 31.5 0.0 4.2e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.23 ORX71200.1 - 3.5e-07 30.3 0.0 2.1e-06 27.8 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ORX71200.1 - 0.0014 18.9 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ORX71200.1 - 0.0028 17.2 0.0 0.01 15.4 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 ORX71200.1 - 0.031 13.6 0.0 0.095 12.0 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Gtr1_RagA PF04670.12 ORX71200.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ORX71200.1 - 0.14 12.5 0.6 0.42 11.0 0.0 2.2 2 2 0 2 2 2 0 AAA ATPase domain YfhD PF14151.6 ORX71201.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 YfhD-like protein ADH_zinc_N PF00107.26 ORX71202.1 - 6.3e-24 84.4 0.6 1e-23 83.7 0.6 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX71202.1 - 4.7e-21 74.7 0.0 1.2e-20 73.4 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX71202.1 - 6.8e-14 53.1 0.0 1.3e-13 52.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ORX71203.1 - 1.3e-26 93.1 0.5 2.1e-26 92.4 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX71203.1 - 2.8e-20 72.2 0.0 7.5e-20 70.9 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX71203.1 - 2.8e-16 60.8 0.0 6.4e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SRP9-21 PF05486.12 ORX71204.1 - 2.2e-09 37.6 1.2 1.4e-07 31.8 1.2 2.3 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) TBD PF12845.7 ORX71204.1 - 0.084 12.8 0.5 0.29 11.0 0.1 2.0 1 1 1 2 2 2 0 TBD domain MFS_1 PF07690.16 ORX71206.1 - 1.3e-18 67.1 37.0 6.7e-11 41.7 24.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PAP_assoc PF03828.19 ORX71209.1 - 0.00025 21.2 0.0 0.00081 19.6 0.0 1.9 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX71209.1 - 0.072 13.4 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain SRF-TF PF00319.18 ORX71210.1 - 1.3e-21 75.8 0.1 1.7e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) tRNA-synt_2 PF00152.20 ORX71211.1 - 2.5e-103 345.5 0.0 3e-103 345.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX71211.1 - 1.9e-11 43.8 0.2 4.5e-11 42.6 0.2 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 ORX71211.1 - 0.0037 17.3 0.0 0.0072 16.3 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 ORX71211.1 - 0.011 15.3 0.2 0.028 13.9 0.2 1.7 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) GST_C_3 PF14497.6 ORX71213.1 - 1.9e-08 34.4 0.0 3.1e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71213.1 - 0.00045 20.5 0.1 0.015 15.6 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71213.1 - 0.00066 19.8 0.0 0.0013 18.9 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX71213.1 - 0.001 19.1 0.0 0.0022 18.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71213.1 - 0.052 14.0 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71213.1 - 0.056 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX71214.1 - 1.2e-09 38.2 0.1 1.9e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71214.1 - 0.0021 18.4 0.0 0.0065 16.8 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71214.1 - 0.0046 17.1 0.0 0.008 16.4 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX71214.1 - 0.063 13.3 0.0 0.15 12.1 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FtsJ PF01728.19 ORX71214.1 - 0.079 13.1 0.0 0.096 12.8 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase GST_C_3 PF14497.6 ORX71215.1 - 9.4e-10 38.6 0.0 1.6e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71215.1 - 0.00025 21.4 0.0 0.00048 20.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX71215.1 - 0.00045 20.5 0.0 0.0019 18.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71215.1 - 0.0075 16.5 0.0 0.023 14.9 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX71216.1 - 4.5e-12 46.0 1.3 7.4e-12 45.3 1.3 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71216.1 - 7e-05 23.1 0.0 0.00024 21.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71216.1 - 0.00019 21.6 0.3 0.00035 20.7 0.3 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71216.1 - 0.00019 21.7 0.0 0.00047 20.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71216.1 - 0.0049 17.2 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX71216.1 - 0.0086 16.1 0.0 0.026 14.6 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF1877 PF08974.10 ORX71216.1 - 0.11 12.6 2.5 0.45 10.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) HxlR PF01638.17 ORX71216.1 - 0.15 12.0 0.0 0.43 10.5 0.0 1.7 2 0 0 2 2 2 0 HxlR-like helix-turn-helix GST_C_3 PF14497.6 ORX71217.1 - 1.2e-06 28.6 0.1 2.1e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71217.1 - 0.00044 20.5 0.0 0.00098 19.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71217.1 - 0.00084 19.5 0.1 0.0012 19.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71217.1 - 0.00094 19.6 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71217.1 - 0.0035 17.6 0.0 0.0071 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX71217.1 - 0.045 13.8 0.1 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ORX71218.1 - 1.5e-31 109.3 0.0 2.9e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 ORX71218.1 - 5.5e-25 86.9 0.2 2.3e-24 84.9 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 ORX71218.1 - 9.2e-19 68.0 0.0 1.8e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 ORX71218.1 - 4.6e-10 39.4 0.0 3.8e-09 36.5 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX71218.1 - 0.0039 17.4 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX71218.1 - 0.043 14.0 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain IBN_N PF03810.19 ORX71219.1 - 0.001 19.0 0.0 0.004 17.0 0.0 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Nitr_red_alph_N PF14710.6 ORX71219.1 - 0.061 13.8 0.1 0.2 12.2 0.1 1.9 1 0 0 1 1 1 0 Respiratory nitrate reductase alpha N-terminal HSF_DNA-bind PF00447.17 ORX71220.1 - 1.1e-31 109.3 4.4 1.1e-31 109.3 4.4 1.7 2 0 0 2 2 2 1 HSF-type DNA-binding EcsC PF12787.7 ORX71220.1 - 0.0085 15.8 0.2 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 EcsC protein family SCHIP-1 PF10148.9 ORX71220.1 - 0.022 14.4 0.6 0.035 13.7 0.6 1.3 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 NDUF_B4 PF07225.12 ORX71221.1 - 0.13 12.1 1.4 0.65 9.9 2.2 1.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) F-box-like PF12937.7 ORX71223.1 - 0.0034 17.2 0.3 0.011 15.7 0.3 1.9 1 0 0 1 1 1 1 F-box-like ADH_zinc_N PF00107.26 ORX71225.1 - 1.4e-24 86.5 0.9 2.3e-24 85.8 0.9 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX71225.1 - 7.9e-21 74.0 0.0 1.6e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX71225.1 - 1.3e-13 52.1 0.0 2.5e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ECH_1 PF00378.20 ORX71226.1 - 1.1e-85 287.0 0.7 1.2e-85 286.8 0.7 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX71226.1 - 1.9e-34 119.7 1.0 2.4e-30 106.2 0.2 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 ORX71226.1 - 0.06 13.3 0.0 0.38 10.7 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 SDH_sah PF01972.16 ORX71226.1 - 0.12 11.4 0.1 0.42 9.6 0.0 1.7 1 1 0 2 2 2 0 Serine dehydrogenase proteinase Ribosomal_L24e PF01246.20 ORX71227.1 - 3.3e-28 97.7 0.5 3.3e-28 97.7 0.5 1.9 2 1 0 2 2 2 1 Ribosomal protein L24e HNOBA PF07701.14 ORX71227.1 - 0.12 11.8 3.1 0.16 11.4 3.1 1.1 1 0 0 1 1 1 0 Heme NO binding associated DUF4554 PF15091.6 ORX71227.1 - 4.7 6.0 8.9 4.7 6.0 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) eIF2A PF08662.11 ORX71228.1 - 6.7e-34 117.5 3.7 1.4e-29 103.4 0.1 5.2 3 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 ORX71228.1 - 1.5e-09 37.6 0.3 3.1e-09 36.5 0.3 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 ORX71228.1 - 0.00028 21.1 0.2 14 6.0 0.0 5.0 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX71228.1 - 0.044 14.7 0.7 2 9.4 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat Pkinase PF00069.25 ORX71229.1 - 1.4e-23 83.6 0.0 2.5e-19 69.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71229.1 - 1.3e-05 24.6 0.0 2.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX71229.1 - 0.00031 19.7 0.0 0.00054 18.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX71229.1 - 0.073 13.0 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family VWA_2 PF13519.6 ORX71231.1 - 1.6e-08 35.1 0.3 2.4e-06 28.2 0.0 2.8 3 0 0 3 3 3 2 von Willebrand factor type A domain Tfb4 PF03850.14 ORX71232.1 - 4.2e-85 285.6 3.6 5e-85 285.3 3.6 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Baculo_IE-1 PF05290.11 ORX71232.1 - 0.31 11.0 6.2 0.71 9.8 6.2 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) OSCP PF00213.18 ORX71235.1 - 2.2e-45 154.9 3.9 2.9e-45 154.5 3.9 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Gal4_dimer PF03902.13 ORX71235.1 - 0.092 12.9 0.6 22 5.3 0.0 2.8 3 0 0 3 3 3 0 Gal4-like dimerisation domain Adaptin_N PF01602.20 ORX71236.1 - 6.7e-90 302.1 5.0 3.8e-75 253.4 3.6 2.2 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 ORX71236.1 - 2.3e-15 57.0 3.0 4.7e-12 46.3 0.0 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX71236.1 - 7.5e-11 41.3 2.7 0.095 13.0 0.0 6.7 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.6 ORX71236.1 - 3.3e-09 37.0 0.2 0.0011 19.3 0.0 4.4 4 0 0 4 4 4 2 HEAT repeats RTP1_C1 PF10363.9 ORX71236.1 - 7e-05 23.0 0.0 0.75 10.0 0.0 3.5 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 ORX71236.1 - 0.014 14.6 0.0 0.13 11.4 0.0 2.4 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain DUF4164 PF13747.6 ORX71237.1 - 8.2e-05 22.8 7.3 8.2e-05 22.8 7.3 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4164) DUF1359 PF07097.11 ORX71237.1 - 0.00065 19.9 0.0 0.0019 18.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1359) SesA PF17107.5 ORX71237.1 - 0.008 16.4 1.7 0.008 16.4 1.7 2.2 1 1 1 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Alkyl_sulf_C PF14864.6 ORX71237.1 - 0.042 14.1 1.5 0.082 13.2 1.2 1.7 1 1 0 1 1 1 0 Alkyl sulfatase C-terminal DUF1328 PF07043.13 ORX71239.1 - 4.3 7.6 5.6 3.6 7.9 1.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1328) Ank_5 PF13857.6 ORX71241.1 - 1.2e-21 76.5 0.2 4.3e-08 33.3 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX71241.1 - 1.3e-18 67.1 0.0 3.1e-11 43.5 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX71241.1 - 3e-18 65.4 4.0 1.3e-06 28.5 0.1 3.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ORX71241.1 - 1.7e-17 61.7 0.2 1.5e-05 25.0 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ORX71241.1 - 5.6e-17 62.1 0.0 9.8e-17 61.3 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) DUF1843 PF08898.10 ORX71241.1 - 0.083 13.4 0.0 17 6.0 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) ScdA_N PF04405.14 ORX71241.1 - 0.15 11.7 0.1 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Domain of Unknown function (DUF542) UBA2_C PF16195.5 ORX71242.1 - 3.1 8.6 8.9 0.76 10.5 2.9 2.8 2 1 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Hydrolase PF00702.26 ORX71244.1 - 7.4e-35 121.1 0.1 1.8e-34 119.9 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX71244.1 - 4.8e-29 101.2 1.0 4.8e-29 101.2 1.0 2.6 2 1 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 ORX71244.1 - 2.4e-25 88.8 0.0 7e-12 45.6 0.0 2.5 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ORX71244.1 - 5.9e-06 26.8 0.0 2e-05 25.1 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CoA_binding_2 PF13380.6 ORX71244.1 - 0.1 13.1 0.1 0.5 10.9 0.1 2.2 1 0 0 1 1 1 0 CoA binding domain ALMT PF11744.8 ORX71244.1 - 0.13 11.1 0.5 0.24 10.2 0.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter EccE PF11203.8 ORX71244.1 - 1.9 8.8 5.1 22 5.4 0.0 3.9 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE ADH_zinc_N PF00107.26 ORX71245.1 - 9.4e-26 90.3 0.9 1.7e-25 89.5 0.9 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX71245.1 - 2.7e-19 69.1 0.0 7.6e-19 67.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX71245.1 - 5.1e-15 56.7 0.0 9.8e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase F-box-like PF12937.7 ORX71247.1 - 0.0038 17.1 0.3 0.011 15.6 0.3 1.9 1 0 0 1 1 1 1 F-box-like Hamartin PF04388.12 ORX71248.1 - 9.9 4.7 5.9 11 4.5 5.9 1.1 1 0 0 1 1 1 0 Hamartin protein Usp PF00582.26 ORX71250.1 - 2.1e-24 86.6 0.1 7.7e-24 84.8 0.1 1.8 1 1 0 1 1 1 1 Universal stress protein family bZIP_2 PF07716.15 ORX71251.1 - 4.2e-09 36.3 16.1 4.2e-09 36.3 16.1 2.0 2 0 0 2 2 2 1 Basic region leucine zipper XhlA PF10779.9 ORX71251.1 - 0.0028 17.8 3.6 0.0052 17.0 3.6 1.4 1 0 0 1 1 1 1 Haemolysin XhlA bZIP_1 PF00170.21 ORX71251.1 - 0.011 15.8 12.1 0.019 15.1 12.1 1.4 1 0 0 1 1 1 0 bZIP transcription factor MPS2 PF17060.5 ORX71251.1 - 0.66 9.2 6.2 1.4 8.1 6.2 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF865 PF05906.11 ORX71251.1 - 3 7.7 7.2 0.14 11.9 0.7 2.2 2 0 0 2 2 2 0 Herpesvirus-7 repeat of unknown function (DUF865) Iso_dh PF00180.20 ORX71252.1 - 5.4e-99 331.6 0.0 6.5e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SYS1 PF09801.9 ORX71253.1 - 2.9e-24 85.9 4.5 8.6e-23 81.1 4.5 2.0 1 1 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network WD40 PF00400.32 ORX71254.1 - 2.2e-34 116.9 23.1 1e-05 26.2 0.2 11.0 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX71254.1 - 0.00035 20.8 0.8 50 4.3 0.1 5.9 5 1 2 7 7 6 1 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 ORX71256.1 - 2.6e-08 33.9 16.0 4.6e-08 33.1 16.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hamartin PF04388.12 ORX71256.1 - 1.7 7.2 6.2 3 6.4 6.2 1.4 1 0 0 1 1 1 0 Hamartin protein IPP-2 PF04979.14 ORX71257.1 - 3.1e-16 60.3 5.4 3.1e-16 60.3 5.4 1.4 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Thioredoxin PF00085.20 ORX71258.1 - 8.4e-25 86.7 0.0 9.3e-25 86.6 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ORX71258.1 - 1.3e-09 37.9 0.0 1.7e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX71258.1 - 5e-07 30.1 0.2 8.6e-06 26.2 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.11 ORX71258.1 - 3.1e-05 23.9 0.0 4e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.6 ORX71258.1 - 9.4e-05 22.7 0.0 0.0011 19.3 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 ORX71258.1 - 0.00014 21.3 0.0 0.00016 21.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 ORX71258.1 - 0.00029 21.0 0.0 0.00037 20.7 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 ORX71258.1 - 0.014 15.4 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin domain AhpC-TSA PF00578.21 ORX71258.1 - 0.02 14.8 0.3 1.1 9.1 0.1 1.9 1 1 1 2 2 2 0 AhpC/TSA family Thioredoxin_7 PF13899.6 ORX71258.1 - 0.064 13.5 0.0 0.1 12.8 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_6 PF13848.6 ORX71258.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain Redoxin PF08534.10 ORX71258.1 - 0.13 12.0 0.3 0.97 9.1 0.3 1.9 1 1 1 2 2 2 0 Redoxin KaiB PF07689.12 ORX71258.1 - 0.2 11.4 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 KaiB domain Thioredoxin PF00085.20 ORX71259.1 - 2.5e-27 94.9 0.1 2.9e-27 94.7 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ORX71259.1 - 7.5e-08 32.2 0.0 9.4e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX71259.1 - 2.8e-07 31.0 0.1 3.4e-06 27.5 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ORX71259.1 - 1.1e-06 28.2 0.0 1.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ORX71259.1 - 7.5e-06 26.2 0.0 1.1e-05 25.7 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ORX71259.1 - 0.0076 16.4 0.1 0.012 15.8 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ORX71259.1 - 0.0085 16.0 0.0 0.0097 15.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family HyaE PF07449.11 ORX71259.1 - 0.028 14.4 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 ORX71259.1 - 0.042 13.6 0.2 0.059 13.1 0.2 1.4 1 1 0 1 1 1 0 Redoxin Glutaredoxin PF00462.24 ORX71259.1 - 0.054 13.7 0.0 0.088 13.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin Translin PF01997.16 ORX71260.1 - 1.4e-49 168.9 3.5 1.6e-49 168.7 3.5 1.0 1 0 0 1 1 1 1 Translin family KxDL PF10241.9 ORX71260.1 - 0.00044 20.5 1.6 0.08 13.2 0.8 2.8 3 0 0 3 3 3 1 Uncharacterized conserved protein Polysacc_synt_2 PF02719.15 ORX71260.1 - 0.019 14.1 0.2 0.099 11.8 0.0 2.0 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein UNC45-central PF11701.8 ORX71260.1 - 0.087 12.8 1.0 0.17 11.9 0.1 1.8 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central ATP-synt_D PF01813.17 ORX71260.1 - 0.11 12.3 2.4 7 6.4 0.1 2.2 2 0 0 2 2 2 0 ATP synthase subunit D DUF1664 PF07889.12 ORX71260.1 - 0.13 12.3 2.7 0.38 10.8 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 ORX71260.1 - 0.39 11.3 3.0 6.5 7.4 1.0 3.0 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Zn_clus PF00172.18 ORX71262.1 - 1.6e-10 40.9 15.4 2.2e-10 40.5 15.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 ORX71264.1 - 1.8e-09 37.6 13.6 1.8e-09 37.6 13.6 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX71266.1 - 0.022 13.8 0.1 0.043 12.8 0.1 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain Abhydrolase_3 PF07859.13 ORX71267.1 - 1.6e-40 139.2 0.0 2.4e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX71267.1 - 1.2e-20 73.7 0.0 9.3e-20 70.8 0.0 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase PPR_2 PF13041.6 ORX71268.1 - 1.4e-28 98.8 0.0 7.4e-09 35.7 0.0 9.1 7 3 3 10 10 10 6 PPR repeat family PPR PF01535.20 ORX71268.1 - 1.6e-24 84.3 0.0 2.4e-05 24.2 0.0 9.1 10 0 0 10 10 10 5 PPR repeat PPR_1 PF12854.7 ORX71268.1 - 3.5e-22 77.8 0.0 1.4e-05 24.7 0.0 7.9 8 0 0 8 8 8 6 PPR repeat PPR_3 PF13812.6 ORX71268.1 - 3.3e-20 71.9 0.0 0.00025 21.1 0.0 6.0 4 3 3 7 7 7 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX71268.1 - 2e-14 53.5 1.2 7.1e-06 25.5 0.1 4.2 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP Replic_Relax PF13814.6 ORX71268.1 - 0.83 9.7 4.3 0.22 11.6 0.5 2.1 3 0 0 3 3 3 0 Replication-relaxation TPR_14 PF13428.6 ORX71268.1 - 3.5 8.7 0.0 3.5 8.7 0.0 7.9 8 2 2 10 10 10 0 Tetratricopeptide repeat SPT_ssu-like PF11779.8 ORX71269.1 - 1.7e-11 43.6 0.6 2.3e-11 43.1 0.6 1.1 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DUF1803 PF08820.10 ORX71269.1 - 0.063 13.3 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) PHD PF00628.29 ORX71271.1 - 7.5e-11 41.7 4.1 1.1e-10 41.2 4.1 1.2 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ORX71271.1 - 0.01 16.1 3.2 0.016 15.4 3.2 1.4 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX71271.1 - 0.058 13.6 2.6 0.091 12.9 2.4 1.4 1 1 0 1 1 1 0 PHD-zinc-finger like domain C1_2 PF03107.16 ORX71271.1 - 0.57 10.5 7.8 0.28 11.5 3.6 2.1 2 0 0 2 2 2 0 C1 domain Zn_ribbon_17 PF17120.5 ORX71271.1 - 0.71 9.6 4.6 1.4 8.6 4.6 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF983 PF06170.12 ORX71271.1 - 1.6 9.2 4.4 0.92 10.0 2.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF983) PHD_2 PF13831.6 ORX71271.1 - 1.8 8.2 8.1 0.28 10.8 2.5 2.4 1 1 0 1 1 1 0 PHD-finger C1_1 PF00130.22 ORX71271.1 - 2.7 7.9 8.6 0.68 9.9 2.5 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_L37e PF01907.19 ORX71271.1 - 6.7 7.0 12.3 2.7 8.2 1.2 3.1 2 1 1 3 3 3 0 Ribosomal protein L37e Brix PF04427.18 ORX71274.1 - 1e-44 153.0 0.1 1.5e-44 152.4 0.1 1.3 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 ORX71274.1 - 0.0046 16.4 21.1 0.0046 16.4 21.1 1.8 2 0 0 2 2 2 1 BUD22 Nop14 PF04147.12 ORX71274.1 - 3.4 5.7 29.6 5.2 5.2 29.6 1.2 1 0 0 1 1 1 0 Nop14-like family SURF2 PF05477.11 ORX71274.1 - 4.7 6.8 18.9 9.5 5.8 18.9 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Presenilin PF01080.17 ORX71274.1 - 9.1 4.9 5.7 15 4.2 5.7 1.4 1 0 0 1 1 1 0 Presenilin zf-CCCH PF00642.24 ORX71275.1 - 9.8e-20 70.0 28.6 1.8e-07 30.9 1.1 4.1 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX71275.1 - 3.8e-19 68.1 36.0 4e-07 29.9 2.7 4.2 4 0 0 4 4 4 4 Zinc finger domain Torus PF16131.5 ORX71275.1 - 7.7e-12 45.9 21.8 0.00046 20.9 1.0 4.0 1 1 3 4 4 4 4 Torus domain zf-CCCH_4 PF18044.1 ORX71275.1 - 1.1e-07 31.5 32.3 3e-07 30.1 0.6 4.0 4 0 0 4 4 4 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX71275.1 - 0.00046 20.6 32.3 0.46 11.0 1.3 5.7 5 1 1 6 6 6 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ORX71275.1 - 0.0078 16.4 19.9 0.032 14.4 9.1 3.6 1 1 2 3 3 3 2 Zinc-finger containing family zf-C3H1 PF10650.9 ORX71275.1 - 0.063 13.0 19.3 1.1 9.1 2.2 4.6 4 1 0 4 4 4 0 Putative zinc-finger domain AWS PF17907.1 ORX71275.1 - 0.068 13.2 14.1 0.58 10.2 0.4 4.2 4 0 0 4 4 4 0 AWS domain Cyto_heme_lyase PF01265.17 ORX71276.1 - 7.6e-29 101.2 19.5 2.2e-25 89.9 19.5 3.4 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase PPR_3 PF13812.6 ORX71277.1 - 4.5e-05 23.4 0.0 3.9 7.6 0.0 4.5 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX71277.1 - 0.0001 21.9 0.1 6.5 6.5 0.0 4.9 4 0 0 4 4 4 1 PPR repeat PPR_2 PF13041.6 ORX71277.1 - 0.0006 20.0 0.6 15 5.8 0.0 5.3 7 0 0 7 7 7 1 PPR repeat family NHR2 PF08788.11 ORX71277.1 - 0.0089 15.8 0.1 0.34 10.7 0.0 3.1 2 1 0 2 2 2 1 NHR2 domain like PPR_long PF17177.4 ORX71277.1 - 0.063 12.6 0.2 2 7.7 0.0 3.2 4 0 0 4 4 4 0 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ORX71277.1 - 0.092 13.0 3.8 39 4.8 0.1 4.9 6 0 0 6 6 6 0 PPR repeat CLU PF13236.6 ORX71278.1 - 1.9e-85 286.2 0.0 3.3e-85 285.4 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ORX71278.1 - 8.6e-39 133.4 1.5 1e-38 133.2 0.0 2.0 2 0 0 2 2 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 ORX71278.1 - 1.4e-22 79.8 0.2 2.9e-22 78.8 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 ORX71278.1 - 1.6e-21 76.4 9.2 1.7e-14 53.9 0.1 3.9 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ORX71278.1 - 8.4e-21 73.2 1.7 1.9e-06 27.6 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX71278.1 - 3.3e-06 26.7 0.1 0.00085 19.0 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX71278.1 - 1.6e-05 24.6 0.2 0.016 15.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX71278.1 - 0.0024 17.9 7.2 3.2 8.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX71278.1 - 0.0034 17.5 0.2 1.9 8.9 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF727 PF05303.12 ORX71278.1 - 0.0044 17.1 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Coilin_N PF15862.5 ORX71278.1 - 0.061 13.1 6.2 0.14 12.0 0.1 2.9 2 1 0 2 2 2 0 Coilin N-terminus TPR_16 PF13432.6 ORX71278.1 - 1.2 9.9 0.0 1.2 9.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX71278.1 - 4.5 7.9 5.0 26 5.5 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat FG-GAP PF01839.23 ORX71279.1 - 3.5e-20 71.8 14.1 9.1e-06 25.7 0.0 4.6 4 0 0 4 4 4 3 FG-GAP repeat Zn_dep_PLPC PF00882.18 ORX71279.1 - 3.1e-15 56.6 0.1 4.8e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 ORX71279.1 - 1.7e-07 31.7 6.3 0.0011 19.6 5.9 3.4 3 1 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TFIIE_alpha PF02002.17 ORX71280.1 - 1.6e-11 44.0 0.4 3.5e-11 42.9 0.4 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 ORX71280.1 - 0.00082 18.8 1.1 0.0022 17.4 1.1 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding AAA_23 PF13476.6 ORX71280.1 - 0.0017 18.9 2.0 0.0038 17.8 2.0 1.5 1 0 0 1 1 1 1 AAA domain HypA PF01155.19 ORX71280.1 - 0.027 14.5 0.3 0.076 13.0 0.3 1.7 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PH_4 PF15404.6 ORX71280.1 - 0.073 12.9 1.8 0.39 10.5 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Cytidylate_kin PF02224.18 ORX71281.1 - 3.4e-55 187.1 3.8 5.6e-53 179.8 3.8 2.8 1 1 0 1 1 1 1 Cytidylate kinase Cytidylate_kin2 PF13189.6 ORX71281.1 - 0.0027 17.9 0.9 0.013 15.6 0.9 2.1 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 ORX71281.1 - 0.021 15.3 0.1 0.2 12.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX71281.1 - 0.25 11.5 1.6 3.4 7.8 0.2 2.8 1 1 0 2 2 2 0 AAA domain MFS_1 PF07690.16 ORX71282.1 - 1.8e-50 171.9 50.2 5.6e-50 170.2 48.6 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX71282.1 - 2.1e-14 53.2 10.8 2.1e-14 53.2 10.8 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ORX71282.1 - 1.7e-13 49.9 26.8 2.4e-12 46.1 26.8 2.2 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 ORX71282.1 - 9.4 4.4 15.8 0.026 12.8 0.9 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Transformer PF06495.11 ORX71283.1 - 0.075 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein zf-CSL PF05207.13 ORX71284.1 - 4.8e-19 67.8 1.2 7.8e-19 67.2 1.2 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 ORX71284.1 - 1.1e-12 47.9 0.2 8.5e-07 29.0 0.1 2.2 1 1 1 2 2 2 2 DnaJ domain Cyanate_lyase PF02560.14 ORX71285.1 - 7.7e-16 57.7 0.0 1.2e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 ORX71285.1 - 0.00011 22.5 0.1 0.0011 19.2 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.6 ORX71285.1 - 0.14 12.6 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain CIAPIN1 PF05093.13 ORX71286.1 - 7.1e-23 81.0 8.9 4.1e-22 78.6 8.9 2.2 1 1 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 ORX71286.1 - 2.6e-05 24.5 0.0 4.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Methyltransf_12 PF08242.12 ORX71286.1 - 0.03 15.1 0.0 0.08 13.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_31 PF01055.26 ORX71287.1 - 4.4e-138 461.2 5.6 6e-138 460.7 5.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ORX71287.1 - 1e-27 96.2 0.6 4.9e-26 90.8 0.1 2.9 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 ORX71287.1 - 8.4e-05 22.8 0.0 0.0002 21.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Thioredoxin PF00085.20 ORX71288.1 - 0.0087 16.0 0.1 0.01 15.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin CbiK PF06180.11 ORX71288.1 - 0.024 14.0 0.3 0.027 13.8 0.3 1.2 1 1 0 1 1 1 0 Cobalt chelatase (CbiK) OPT PF03169.15 ORX71289.1 - 1.4e-149 499.6 49.9 1.6e-149 499.4 49.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PufQ PF05398.11 ORX71289.1 - 0.21 11.8 1.7 4.1 7.6 0.2 2.8 2 0 0 2 2 2 0 PufQ cytochrome subunit DUF4191 PF13829.6 ORX71289.1 - 1.1 8.6 4.0 2.7 7.3 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Invas_SpaK PF03519.14 ORX71291.1 - 0.17 12.0 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Invasion protein B family SCAMP PF04144.13 ORX71293.1 - 3.9e-49 167.3 15.4 5e-49 166.9 15.4 1.1 1 0 0 1 1 1 1 SCAMP family DUF3552 PF12072.8 ORX71293.1 - 0.076 12.4 1.1 0.13 11.7 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF4200 PF13863.6 ORX71293.1 - 0.28 11.6 2.0 0.41 11.1 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF2417 PF10329.9 ORX71293.1 - 0.72 9.2 10.5 0.52 9.7 4.7 2.2 1 1 1 2 2 2 0 Region of unknown function (DUF2417) SAP PF02037.27 ORX71294.1 - 1.3e-12 47.2 0.6 2.9e-12 46.1 0.6 1.6 1 0 0 1 1 1 1 SAP domain RRM_1 PF00076.22 ORX71294.1 - 4.8e-06 26.3 0.3 1.5e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 ORX71294.1 - 0.087 12.5 0.0 0.5 10.1 0.0 2.2 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Afi1 PF07792.12 ORX71294.1 - 1.4 9.4 11.9 2.4 8.6 0.4 2.4 2 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Med19 PF10278.9 ORX71294.1 - 3.6 7.5 10.0 0.4 10.6 1.5 2.3 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 DUF913 PF06025.12 ORX71294.1 - 7.6 5.4 11.6 0.86 8.5 2.2 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) MFS_1 PF07690.16 ORX71297.1 - 2.5e-16 59.6 51.8 6.3e-12 45.1 26.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0239 PF06783.11 ORX71297.1 - 0.13 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Aa_trans PF01490.18 ORX71298.1 - 2.7e-87 293.1 25.3 3.3e-87 292.8 25.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX71298.1 - 1.5e-08 34.1 14.7 1.5e-08 34.1 14.7 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family IucA_IucC PF04183.12 ORX71299.1 - 2.8e-26 92.5 0.0 4.4e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 ORX71299.1 - 5.1e-10 40.0 0.0 8.5e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter Cpn60_TCP1 PF00118.24 ORX71301.1 - 4.5e-157 523.6 11.5 5.1e-157 523.4 11.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Carm_PH PF17888.1 ORX71301.1 - 0.066 13.6 0.1 0.31 11.4 0.0 2.1 2 0 0 2 2 2 0 Carmil pleckstrin homology domain Ribosomal_L3 PF00297.22 ORX71302.1 - 5e-21 75.1 2.3 2e-17 63.2 0.3 2.7 1 1 1 3 3 3 2 Ribosomal protein L3 DUF2340 PF10209.9 ORX71303.1 - 9.4e-45 152.0 0.2 1.1e-44 151.8 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Blt1 PF12754.7 ORX71303.1 - 0.035 14.4 0.0 0.037 14.3 0.0 1.1 1 0 0 1 1 1 0 Blt1 N-terminal domain Ubiquitin_4 PF18036.1 ORX71303.1 - 0.12 12.4 0.2 15 5.7 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain SNF2_N PF00176.23 ORX71304.1 - 1.5e-74 250.8 0.1 3.6e-74 249.6 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX71304.1 - 2.7e-21 76.0 2.2 2.2e-19 69.8 0.0 3.9 5 0 0 5 5 5 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 ORX71304.1 - 9e-21 73.7 0.4 4.2e-20 71.6 0.2 2.2 2 0 0 2 2 2 1 Bromodomain HSA PF07529.13 ORX71304.1 - 3.1e-16 59.5 13.3 3.1e-16 59.5 13.3 4.0 4 0 0 4 4 4 1 HSA ResIII PF04851.15 ORX71304.1 - 3.6e-10 40.1 0.3 1.6e-09 38.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SnAC PF14619.6 ORX71304.1 - 2.5e-08 34.4 9.9 2.5e-08 34.4 9.9 4.1 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 ORX71304.1 - 5.1e-07 29.3 2.0 5.1e-07 29.3 2.0 3.0 4 0 0 4 4 4 1 QLQ HDA2-3 PF11496.8 ORX71304.1 - 9.8e-07 28.2 0.0 2.8e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 ORX71304.1 - 6.5e-06 26.0 0.9 5.2e-05 23.0 0.0 2.8 3 0 0 3 3 3 1 SWI2/SNF2 ATPase DUF3881 PF12997.7 ORX71304.1 - 1.7 7.8 4.1 0.86 8.8 0.8 1.9 1 1 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) UbiA PF01040.18 ORX71305.1 - 3.4e-52 177.2 22.4 5.5e-52 176.6 19.1 2.0 1 1 1 2 2 2 2 UbiA prenyltransferase family UCR_UQCRX_QCR9 PF05365.12 ORX71305.1 - 0.19 11.7 4.7 0.34 10.9 0.0 2.7 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like FAR1 PF03101.15 ORX71307.1 - 0.12 13.1 0.2 0.21 12.3 0.2 1.4 1 0 0 1 1 1 0 FAR1 DNA-binding domain Cyt-b5 PF00173.28 ORX71308.1 - 1.5e-22 79.5 0.0 2e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YlbD_coat PF14071.6 ORX71309.1 - 0.16 12.3 0.8 0.3 11.3 0.8 1.5 1 1 0 1 1 1 0 Putative coat protein AAA PF00004.29 ORX71310.1 - 3.3e-93 309.0 0.0 1.9e-45 154.5 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX71310.1 - 1.9e-24 85.2 1.2 2.2e-11 43.4 0.4 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ORX71310.1 - 1.7e-15 57.1 0.0 7.7e-09 35.5 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX71310.1 - 1.4e-12 48.1 0.0 2.3e-05 24.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ORX71310.1 - 8.9e-12 45.2 0.4 1.6e-05 24.9 0.0 4.4 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX71310.1 - 6.1e-11 43.0 0.7 0.0032 17.9 0.0 4.7 3 2 2 5 5 4 2 AAA ATPase domain TIP49 PF06068.13 ORX71310.1 - 1.2e-10 41.1 0.0 0.00015 21.1 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 ORX71310.1 - 4.4e-09 36.7 0.5 0.072 13.4 0.0 4.9 2 2 3 5 5 5 2 AAA domain AAA_33 PF13671.6 ORX71310.1 - 7.6e-09 35.9 0.0 0.0034 17.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 ORX71310.1 - 2e-07 31.3 0.0 0.015 15.7 0.0 2.8 2 1 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 ORX71310.1 - 3.1e-07 30.3 1.3 0.011 15.5 0.0 3.0 3 1 0 3 3 3 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 ORX71310.1 - 3.6e-07 29.8 0.4 0.011 15.1 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ORX71310.1 - 4.7e-07 29.9 0.0 0.022 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ORX71310.1 - 7.1e-07 29.6 0.0 0.01 16.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 ORX71310.1 - 2.7e-06 27.4 0.1 0.018 14.9 0.0 3.3 3 0 0 3 3 3 2 NACHT domain ABC_tran PF00005.27 ORX71310.1 - 5.8e-06 26.9 0.0 0.044 14.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter Sigma54_activat PF00158.26 ORX71310.1 - 1.2e-05 25.1 0.0 0.094 12.4 0.0 3.3 2 1 1 3 3 3 2 Sigma-54 interaction domain AAA_3 PF07726.11 ORX71310.1 - 1.6e-05 24.7 0.0 0.018 14.9 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ORX71310.1 - 2.7e-05 24.6 0.0 0.26 11.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain TsaE PF02367.17 ORX71310.1 - 2.9e-05 24.1 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ORX71310.1 - 4.1e-05 23.2 0.0 0.19 11.2 0.0 3.1 2 1 0 2 2 2 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX71310.1 - 4.7e-05 22.7 0.1 0.33 10.2 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Vps4_C PF09336.10 ORX71310.1 - 5.4e-05 23.1 0.0 0.21 11.6 0.0 2.8 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 ORX71310.1 - 5.4e-05 22.5 0.0 0.02 14.1 0.0 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ORX71310.1 - 9.9e-05 22.9 0.0 0.63 10.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ORX71310.1 - 0.0001 21.9 3.3 0.32 10.6 0.0 4.2 2 2 2 4 4 4 1 AAA domain Parvo_NS1 PF01057.17 ORX71310.1 - 0.00014 21.0 0.1 0.44 9.6 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ATPase PF06745.13 ORX71310.1 - 0.00015 21.2 0.6 2.2 7.6 0.0 3.2 2 1 1 3 3 3 2 KaiC NB-ARC PF00931.22 ORX71310.1 - 0.00026 20.3 0.0 0.92 8.6 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 ORX71310.1 - 0.0004 20.2 0.0 0.32 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 ORX71310.1 - 0.0004 19.8 0.0 4.9 6.5 0.0 3.9 4 0 0 4 4 4 0 Bacterial TniB protein AAA_11 PF13086.6 ORX71310.1 - 0.00071 19.4 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AFG1_ATPase PF03969.16 ORX71310.1 - 0.00073 18.5 0.0 0.49 9.2 0.0 2.4 2 0 0 2 2 2 2 AFG1-like ATPase Sigma54_activ_2 PF14532.6 ORX71310.1 - 0.002 18.2 0.0 1.7 8.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Cytidylate_kin2 PF13189.6 ORX71310.1 - 0.0022 18.1 0.0 0.33 11.1 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family CPT PF07931.12 ORX71310.1 - 0.0035 17.2 0.0 0.32 10.8 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein Rad17 PF03215.15 ORX71310.1 - 0.0045 16.9 0.0 0.22 11.4 0.0 2.6 2 1 0 2 2 2 1 Rad17 P-loop domain PhoH PF02562.16 ORX71310.1 - 0.0095 15.4 0.1 5.6 6.4 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 ORX71310.1 - 0.03 14.2 0.0 10 6.0 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 ORX71310.1 - 0.031 14.1 0.0 6 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein Viral_helicase1 PF01443.18 ORX71310.1 - 0.045 13.5 0.0 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 ORX71310.1 - 0.052 13.5 0.4 11 5.9 0.0 2.8 3 0 0 3 3 2 0 NTPase DUF2075 PF09848.9 ORX71310.1 - 0.052 12.8 0.1 8.4 5.5 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 ORX71310.1 - 0.069 13.6 0.0 0.54 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX71310.1 - 0.081 13.3 2.2 7.9 6.8 0.2 2.9 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ORX71310.1 - 0.085 12.6 0.2 16 5.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ORX71310.1 - 0.14 11.9 0.0 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 ORX71310.1 - 0.17 11.7 0.0 24 4.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX71310.1 - 0.2 11.8 0.3 8.5 6.5 0.0 3.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase JAB PF01398.21 ORX71311.1 - 4.4e-12 46.0 0.0 7.3e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 ORX71311.1 - 4.5e-08 33.9 0.0 9.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 ORX71311.1 - 0.017 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain SRP40_C PF05022.12 ORX71312.1 - 2.6e-22 79.4 5.6 2.6e-22 79.4 5.6 2.1 2 0 0 2 2 2 1 SRP40, C-terminal domain DUF755 PF05501.11 ORX71312.1 - 0.0021 18.3 5.5 0.0021 18.3 5.5 5.1 4 1 1 5 5 5 2 Domain of unknown function (DUF755) Chorion_2 PF03964.15 ORX71312.1 - 0.026 15.4 2.8 0.026 15.4 2.8 4.8 1 1 2 3 3 3 0 Chorion family 2 TRAP_alpha PF03896.16 ORX71312.1 - 0.044 13.0 5.1 0.058 12.6 1.3 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF4776 PF16003.5 ORX71312.1 - 0.21 10.6 16.4 0.27 10.2 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SOG2 PF10428.9 ORX71312.1 - 0.28 10.4 32.4 0.36 10.0 32.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein YabA PF06156.13 ORX71312.1 - 1 10.0 3.9 0.51 11.0 1.4 1.8 2 0 0 2 2 2 0 Initiation control protein YabA RP-C_C PF11800.8 ORX71312.1 - 1.9 8.6 23.3 0.5 10.4 4.8 2.3 1 1 0 2 2 2 0 Replication protein C C-terminal region Ecl1 PF12855.7 ORX71312.1 - 2.3 9.4 37.7 3.6 8.7 37.7 1.4 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins Glyco_hydro_19 PF00182.19 ORX71313.1 - 4.4e-17 62.7 0.4 1.6e-11 44.6 0.1 2.0 1 1 1 2 2 2 2 Chitinase class I Mob1_phocein PF03637.17 ORX71314.1 - 9.6e-40 136.4 0.4 1.2e-39 136.1 0.4 1.0 1 0 0 1 1 1 1 Mob1/phocein family Bromodomain PF00439.25 ORX71316.1 - 3.2e-17 62.4 0.2 6.7e-17 61.3 0.2 1.6 1 0 0 1 1 1 1 Bromodomain Atg8 PF02991.16 ORX71317.1 - 1.8e-52 175.9 0.2 2.1e-52 175.6 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 ORX71317.1 - 3.3e-06 27.4 0.0 4.1e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Orn_Arg_deC_N PF02784.16 ORX71318.1 - 6.6e-82 274.6 0.0 8e-82 274.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ORX71318.1 - 3.6e-18 65.6 0.0 4e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 ORX71318.1 - 0.016 14.7 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel RRM_1 PF00076.22 ORX71319.1 - 4.8e-16 58.3 0.0 8e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DASH_Dam1 PF08653.10 ORX71319.1 - 0.23 11.3 0.3 0.41 10.5 0.3 1.4 1 0 0 1 1 1 0 DASH complex subunit Dam1 Cwf_Cwc_15 PF04889.12 ORX71319.1 - 2 8.1 17.2 2.7 7.6 17.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein LsmAD PF06741.13 ORX71320.1 - 2.5e-25 88.8 1.8 2.5e-25 88.8 1.8 2.3 3 0 0 3 3 3 1 LsmAD domain SM-ATX PF14438.6 ORX71320.1 - 1.3e-08 34.9 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF3584 PF12128.8 ORX71320.1 - 0.48 7.9 5.8 0.77 7.2 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ribosomal_L9_C PF03948.14 ORX71321.1 - 9e-13 48.5 1.3 1.4e-12 47.9 0.6 1.7 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 ORX71321.1 - 4.2e-10 39.0 0.0 9e-10 38.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain adh_short_C2 PF13561.6 ORX71322.1 - 7.1e-43 146.8 0.0 8.3e-43 146.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX71322.1 - 1.1e-35 122.9 0.0 1.7e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX71322.1 - 1e-10 41.9 0.0 3.6e-10 40.0 0.0 1.8 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 ORX71322.1 - 0.00078 18.9 0.0 0.00088 18.7 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 ORX71322.1 - 0.075 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Ribosomal_L11_N PF03946.14 ORX71322.1 - 0.084 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain Herpes_glycoH_C PF17488.2 ORX71322.1 - 0.086 12.6 0.3 0.61 9.9 0.1 2.4 2 1 0 2 2 2 0 Herpesvirus glycoprotein H C-terminal domain VWA_CoxE PF05762.14 ORX71322.1 - 0.1 12.0 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein GDP_Man_Dehyd PF16363.5 ORX71322.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 ORX71323.1 - 3.2e-65 220.7 0.0 4e-65 220.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 ORX71324.1 - 1.8e-71 234.3 21.2 6.9e-08 33.0 0.1 11.5 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp13 PF08625.11 ORX71324.1 - 1.1e-48 164.7 0.3 1.1e-48 164.7 0.3 1.7 2 0 0 2 2 2 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 ORX71324.1 - 7.3e-16 58.2 5.3 0.24 11.7 0.1 9.2 5 2 5 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX71324.1 - 1.7e-11 44.0 0.2 0.00096 18.6 0.0 4.7 4 2 2 6 6 6 3 WD40-like domain Nup160 PF11715.8 ORX71324.1 - 4.7e-10 38.7 11.2 0.44 9.1 0.1 8.3 6 2 3 9 9 9 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX71324.1 - 4.5e-07 29.0 1.5 0.86 8.3 0.0 5.7 4 2 1 6 6 6 2 Nup133 N terminal like eIF2A PF08662.11 ORX71324.1 - 3.7e-05 23.7 2.7 0.21 11.5 0.0 4.7 3 2 3 6 6 6 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX71324.1 - 7.8e-05 21.4 1.2 0.063 11.8 0.0 3.7 3 1 0 4 4 4 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ORX71324.1 - 0.00015 20.8 5.3 5.1 6.0 0.3 5.7 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 ORX71324.1 - 0.00025 20.9 3.4 0.72 9.5 0.1 4.9 4 1 1 5 5 5 2 TUP1-like enhancer of split PQQ_2 PF13360.6 ORX71324.1 - 0.0012 18.5 0.3 1.2 8.7 0.0 3.2 3 1 0 3 3 3 2 PQQ-like domain BBS2_Mid PF14783.6 ORX71324.1 - 0.0015 18.6 0.1 2.5 8.2 0.0 3.9 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PALB2_WD40 PF16756.5 ORX71324.1 - 0.014 14.3 7.0 0.27 10.1 0.2 4.1 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF3677 PF12432.8 ORX71324.1 - 0.019 15.3 0.0 0.05 13.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) ELYS-bb PF16687.5 ORX71324.1 - 0.066 11.8 0.0 5.1 5.6 0.0 2.6 3 0 0 3 3 3 0 beta-propeller of ELYS nucleoporin Complex1_LYR PF05347.15 ORX71325.1 - 4.3e-07 29.9 0.1 7.9e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX71325.1 - 0.0075 17.0 0.7 0.015 16.1 0.7 1.7 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 ORX71325.1 - 0.023 15.3 0.1 0.054 14.1 0.1 1.6 1 1 0 1 1 1 0 Complex1_LYR-like DUF1848 PF08902.11 ORX71325.1 - 0.068 12.9 0.0 0.092 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) DUF4635 PF15466.6 ORX71325.1 - 0.096 12.2 0.5 0.14 11.7 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4635) RNase_H PF00075.24 ORX71326.1 - 1.8e-18 67.1 0.3 4.6e-18 65.8 0.3 1.6 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 ORX71326.1 - 3.7e-09 36.5 0.0 3.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like CHCH PF06747.13 ORX71327.1 - 2.9e-05 24.1 7.6 3e-05 24.0 4.2 2.2 2 0 0 2 2 2 1 CHCH domain SURF6 PF04935.12 ORX71327.1 - 0.0024 17.7 0.2 0.0026 17.6 0.2 1.0 1 0 0 1 1 1 1 Surfeit locus protein 6 DUF3551 PF12071.8 ORX71327.1 - 0.0069 16.4 2.7 0.0069 16.4 2.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3551) MTCP1 PF08991.10 ORX71327.1 - 0.0093 16.2 7.5 0.013 15.7 7.5 1.4 1 1 0 1 1 1 1 Mature-T-Cell Proliferation I type JTB PF05439.12 ORX71327.1 - 0.57 10.2 5.5 0.063 13.3 1.1 1.6 1 1 1 2 2 2 0 Jumping translocation breakpoint protein (JTB) CTP_transf_like PF01467.26 ORX71328.1 - 8.1e-20 71.5 0.0 1e-19 71.2 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Mannosyl_trans PF05007.13 ORX71329.1 - 1.1e-81 274.5 22.4 1.1e-81 274.5 22.4 1.6 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 ORX71329.1 - 3.3e-11 42.9 19.1 4.5e-11 42.4 19.1 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 ORX71329.1 - 0.00049 19.9 16.1 0.00049 19.9 16.1 2.3 1 1 1 2 2 2 1 Glycosyltransferase family 87 CnrY PF17524.2 ORX71329.1 - 0.74 10.1 2.8 35 4.7 0.3 2.7 2 0 0 2 2 2 0 Anti-sigma factor CnrY Longin PF13774.6 ORX71330.1 - 3.2e-26 91.2 0.1 4.8e-26 90.6 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ORX71330.1 - 3.9e-15 55.4 0.0 7.4e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin Lectin_N PF03954.14 ORX71330.1 - 0.036 13.8 0.7 0.062 13.0 0.7 1.3 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DDE_Tnp_1 PF01609.21 ORX71331.1 - 0.055 13.1 0.0 0.055 13.1 0.0 1.0 1 0 0 1 1 1 0 Transposase DDE domain Ribosomal_L31e PF01198.19 ORX71331.1 - 0.17 12.1 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L31e Syja_N PF02383.18 ORX71332.1 - 7.1e-63 212.9 0.0 9.5e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 ORX71332.1 - 2.1e-19 69.3 0.0 3.3e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Inositol phosphatase Glyco_transf_28 PF03033.20 ORX71332.1 - 0.0062 16.6 0.1 0.028 14.5 0.0 2.1 1 1 1 2 2 2 1 Glycosyltransferase family 28 N-terminal domain FNIP_C PF14638.6 ORX71332.1 - 0.12 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus Epimerase PF01370.21 ORX71334.1 - 1.6e-10 40.8 0.0 7.1e-10 38.8 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX71334.1 - 1.6e-09 37.2 0.3 1.6e-08 33.9 0.0 2.3 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ORX71334.1 - 6e-09 35.4 0.0 0.0022 17.1 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.6 ORX71334.1 - 1.2e-08 35.1 0.0 1.9e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX71334.1 - 4e-05 23.3 0.2 0.00017 21.3 0.2 2.0 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 ORX71334.1 - 0.00042 19.6 0.9 0.15 11.2 0.1 3.0 2 1 1 3 3 3 2 Male sterility protein Sacchrp_dh_NADP PF03435.18 ORX71334.1 - 0.029 14.6 0.0 0.072 13.3 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 ORX71334.1 - 0.12 11.8 0.3 1 8.7 0.0 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Aminotran_3 PF00202.21 ORX71335.1 - 3.9e-114 381.4 0.0 6.8e-114 380.7 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III Gpi16 PF04113.14 ORX71336.1 - 7.7e-146 486.8 0.0 6.7e-144 480.4 0.0 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Pkinase PF00069.25 ORX71337.1 - 1.5e-53 181.9 0.0 1.7e-53 181.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71337.1 - 2.9e-29 102.2 0.0 3.5e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71337.1 - 7.1e-09 35.4 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX71337.1 - 3.9e-05 23.1 0.0 6.7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX71337.1 - 0.00084 19.3 0.6 0.056 13.4 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX71337.1 - 0.0024 16.9 0.0 0.003 16.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ORX71337.1 - 0.0098 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Mhr1 PF12829.7 ORX71338.1 - 7.4e-10 38.8 0.1 2e-09 37.4 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulation of mitochondrial recombination HECT PF00632.25 ORX71339.1 - 2.4e-96 322.8 0.1 3.1e-96 322.5 0.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 ORX71339.1 - 3.1e-35 119.9 14.9 4.8e-12 45.7 0.2 3.9 4 0 0 4 4 4 3 WW domain C2 PF00168.30 ORX71339.1 - 1e-16 61.1 0.2 5e-16 58.9 0.1 2.1 2 0 0 2 2 2 1 C2 domain RRM_1 PF00076.22 ORX71340.1 - 5.2e-05 23.0 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Yae1_N PF09811.9 ORX71340.1 - 0.00021 20.9 5.2 0.14 11.9 2.2 2.5 2 0 0 2 2 2 2 Essential protein Yae1, N terminal SARAF PF06682.12 ORX71340.1 - 0.037 13.7 1.5 0.052 13.2 1.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pkinase PF00069.25 ORX71341.1 - 7.3e-73 245.2 0.1 1.2e-72 244.5 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71341.1 - 1.7e-34 119.3 0.2 2.9e-34 118.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX71341.1 - 5.2e-05 22.3 0.6 0.00089 18.3 0.0 2.4 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ORX71341.1 - 0.0071 16.3 1.1 0.051 13.5 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF4603 PF15376.6 ORX71342.1 - 0.31 8.4 0.0 0.41 8.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) OrsD PF12013.8 ORX71343.1 - 6.9e-06 26.5 2.4 1.1e-05 25.8 0.1 2.2 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D PriA_CRR PF18319.1 ORX71343.1 - 0.0059 16.6 3.3 0.014 15.4 0.2 2.8 2 0 0 2 2 2 1 PriA DNA helicase Cys-rich region (CRR) domain zf-C2H2_4 PF13894.6 ORX71343.1 - 0.052 14.4 0.7 0.052 14.4 0.7 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX71343.1 - 0.083 13.4 11.3 0.2 12.2 1.1 4.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Ribosomal_L7Ae PF01248.26 ORX71344.1 - 1.1e-28 98.7 0.0 1.5e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 ORX71344.1 - 0.0014 18.4 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 ORX71344.1 - 0.0024 17.9 0.0 0.0027 17.8 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 FlxA PF14282.6 ORX71344.1 - 0.2 11.7 2.8 9.2 6.3 0.3 2.2 2 0 0 2 2 2 0 FlxA-like protein Peptidase_M3 PF01432.20 ORX71345.1 - 2.3e-100 337.0 0.0 1.4e-98 331.1 0.0 2.2 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 ORX71345.1 - 0.16 11.6 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Dynamin_M PF01031.20 ORX71346.1 - 1.4e-77 260.7 0.5 4.5e-73 245.9 0.1 2.5 1 1 1 2 2 2 2 Dynamin central region Dynamin_N PF00350.23 ORX71346.1 - 6.5e-56 189.0 0.0 1.3e-55 188.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ORX71346.1 - 3.9e-29 100.6 3.3 3.9e-29 100.6 3.3 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ORX71346.1 - 0.00014 21.9 0.1 0.0004 20.5 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX71346.1 - 0.058 13.8 0.0 0.39 11.1 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain WD40 PF00400.32 ORX71347.1 - 0.002 18.9 0.0 0.0056 17.5 0.0 1.7 2 0 0 2 2 2 1 WD domain, G-beta repeat UPF0121 PF03661.13 ORX71348.1 - 0.036 13.5 0.5 0.06 12.7 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0121) CorA PF01544.18 ORX71349.1 - 0.01 15.2 11.4 0.042 13.2 8.5 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF896 PF05979.12 ORX71349.1 - 0.17 11.8 0.0 0.17 11.8 0.0 3.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF896) FlaC_arch PF05377.11 ORX71349.1 - 0.25 11.8 7.9 3.4 8.1 0.0 3.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Terminase_2 PF03592.16 ORX71349.1 - 0.77 10.2 9.8 0.96 9.9 8.9 1.6 1 1 0 1 1 1 0 Terminase small subunit FUSC PF04632.12 ORX71349.1 - 1.1 7.7 6.3 1.7 7.1 6.3 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family ALMT PF11744.8 ORX71349.1 - 1.3 7.7 5.1 1.6 7.5 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Vfa1 PF08432.10 ORX71349.1 - 3.7 7.8 9.1 9.5 6.5 9.1 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FPP PF05911.11 ORX71349.1 - 4 5.5 25.8 0.15 10.2 18.7 1.8 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF4407 PF14362.6 ORX71349.1 - 4.5 6.5 21.5 16 4.7 21.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) zf-CHY PF05495.12 ORX71350.1 - 6.1e-20 71.5 18.3 6.1e-20 71.5 18.3 4.1 3 1 0 3 3 3 1 CHY zinc finger zinc_ribbon_6 PF14599.6 ORX71350.1 - 8.7e-19 67.3 8.5 8.7e-19 67.3 8.5 4.5 3 1 1 5 5 5 1 Zinc-ribbon zf-RING_2 PF13639.6 ORX71350.1 - 9.9e-10 38.6 7.4 9.9e-10 38.6 7.4 5.7 3 2 2 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX71350.1 - 1.6e-06 27.8 7.1 1.6e-06 27.8 7.1 5.9 7 2 0 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71350.1 - 0.00012 22.3 9.6 0.00012 22.3 9.6 4.9 3 3 3 6 6 6 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX71350.1 - 0.00099 19.0 8.6 0.00099 19.0 8.6 6.5 3 2 3 6 6 6 2 zinc-RING finger domain G6PD_C PF02781.16 ORX71351.1 - 9.8e-109 363.0 0.0 1.4e-108 362.5 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ORX71351.1 - 1.2e-60 205.2 0.2 2e-60 204.5 0.2 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain UQ_con PF00179.26 ORX71352.1 - 3.4e-42 143.4 0.0 4.1e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX71352.1 - 0.012 15.4 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Radical_SAM PF04055.21 ORX71353.1 - 7.3e-13 49.2 0.0 1.6e-12 48.1 0.0 1.5 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ORX71353.1 - 6.9e-06 26.2 0.0 1.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ORX71353.1 - 0.0086 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain SAPS PF04499.15 ORX71354.1 - 1.3 7.8 7.2 1.6 7.4 7.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ribosomal_L11_N PF03946.14 ORX71355.1 - 4.3e-24 84.1 0.2 6.3e-24 83.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ORX71355.1 - 7.3e-09 36.0 0.9 1.3e-07 32.0 0.2 2.7 2 1 0 2 2 2 1 Ribosomal protein L11, RNA binding domain AgI_II_C2 PF17998.1 ORX71355.1 - 0.088 13.1 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Cell surface antigen I/II C2 terminal domain IF2_N PF04760.15 ORX71355.1 - 0.095 12.5 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Thioredoxin PF00085.20 ORX71356.1 - 6.5e-63 209.2 2.4 1.1e-31 108.9 0.1 3.5 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 ORX71356.1 - 1.2e-29 103.6 2.9 3.5e-19 69.4 0.9 3.7 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ORX71356.1 - 6.2e-11 42.7 0.2 0.00077 19.9 0.0 3.1 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ORX71356.1 - 7.9e-10 38.8 0.2 0.0013 18.9 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_8 PF13905.6 ORX71356.1 - 4.2e-08 33.4 1.9 0.055 13.8 0.0 4.8 4 2 1 5 5 5 2 Thioredoxin-like AhpC-TSA PF00578.21 ORX71356.1 - 9.7e-08 32.0 1.3 0.0099 15.8 0.1 3.2 3 1 0 3 3 3 2 AhpC/TSA family OST3_OST6 PF04756.13 ORX71356.1 - 6.9e-07 28.9 0.2 0.018 14.4 0.0 2.5 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Redoxin PF08534.10 ORX71356.1 - 2.2e-05 24.2 1.4 0.061 13.0 0.0 3.1 3 0 0 3 3 3 2 Redoxin Calsequestrin PF01216.17 ORX71356.1 - 3e-05 23.2 1.9 3e-05 23.2 1.9 3.1 3 1 1 4 4 4 1 Calsequestrin Glutaredoxin PF00462.24 ORX71356.1 - 0.021 15.0 1.0 6.2 7.1 0.5 3.4 2 1 0 2 2 2 0 Glutaredoxin TraF PF13728.6 ORX71356.1 - 0.064 13.1 4.8 2.1 8.1 0.0 3.0 3 0 0 3 3 2 0 F plasmid transfer operon protein Tautomerase PF01361.21 ORX71356.1 - 0.11 12.4 0.1 3.1 7.8 0.0 2.9 2 0 0 2 2 2 0 Tautomerase enzyme Thioredoxin_4 PF13462.6 ORX71356.1 - 0.31 11.2 2.8 17 5.5 0.1 3.1 3 1 0 3 3 3 0 Thioredoxin DS PF01916.17 ORX71357.1 - 3.3e-118 394.1 0.0 5.5e-118 393.4 0.0 1.3 1 1 0 1 1 1 1 Deoxyhypusine synthase Ribosomal_L15e PF00827.17 ORX71358.1 - 2.7e-87 291.4 9.3 3.2e-87 291.2 9.3 1.0 1 0 0 1 1 1 1 Ribosomal L15 MCM PF00493.23 ORX71359.1 - 5.5e-96 320.0 0.1 4.6e-95 317.0 0.0 2.1 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 ORX71359.1 - 1.1e-36 125.4 0.7 2.2e-36 124.5 0.7 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX71359.1 - 4.9e-28 97.4 0.6 1.3e-27 96.1 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX71359.1 - 6.3e-15 55.6 0.0 1.5e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX71359.1 - 8e-07 28.6 0.0 0.00034 20.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX71359.1 - 5e-05 23.2 0.0 0.0013 18.6 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX71359.1 - 0.00021 21.3 0.0 0.00066 19.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX71359.1 - 0.045 13.4 0.3 2.3 7.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain WD40 PF00400.32 ORX71360.1 - 1.5e-19 70.0 10.7 7.3e-06 26.6 0.1 6.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX71360.1 - 2.8e-10 40.4 0.5 9.1e-06 25.9 0.0 4.2 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CLTH PF10607.9 ORX71360.1 - 0.004 17.0 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain WD40_like PF17005.5 ORX71360.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain FAM176 PF14851.6 ORX71360.1 - 0.045 13.4 3.4 0.088 12.5 3.4 1.4 1 0 0 1 1 1 0 FAM176 family DUF4632 PF15451.6 ORX71360.1 - 0.059 13.5 2.8 0.23 11.5 2.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Frtz PF11768.8 ORX71360.1 - 0.11 10.8 0.0 0.44 8.8 0.0 1.8 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF2544 PF11245.8 ORX71360.1 - 0.16 11.4 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2544) DUF4611 PF15387.6 ORX71360.1 - 0.23 11.7 4.1 0.51 10.6 4.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Radial_spoke PF04712.12 ORX71360.1 - 0.26 10.2 1.0 0.38 9.6 1.0 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein PBP1_TM PF14812.6 ORX71360.1 - 0.53 10.7 8.2 1.2 9.6 8.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 ORX71360.1 - 2.7 6.2 4.7 4.1 5.6 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ORX71360.1 - 8.2 5.7 9.8 14 4.9 9.8 1.2 1 0 0 1 1 1 0 NOA36 protein B56 PF01603.20 ORX71361.1 - 8.3e-169 561.9 2.0 1e-168 561.6 2.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RNA_pol_Rpc82 PF05645.13 ORX71361.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 Fucose_iso_N2 PF07882.12 ORX71361.1 - 0.076 12.6 0.3 5.5 6.5 0.0 2.3 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain NAD1 PF18778.1 ORX71361.1 - 0.21 11.7 2.3 9 6.4 0.6 2.3 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 Pkinase_fungal PF17667.1 ORX71362.1 - 1.8e-57 195.0 0.0 2.3e-29 102.4 0.0 2.5 2 1 0 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX71362.1 - 0.077 12.4 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain RIO1 PF01163.22 ORX71362.1 - 0.082 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 RIO1 family ATP-synt_ab PF00006.25 ORX71363.1 - 1.7e-104 348.1 0.0 4.2e-104 346.8 0.0 1.7 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.16 ORX71363.1 - 2.5e-82 276.3 0.1 3.8e-82 275.6 0.1 1.3 1 0 0 1 1 1 1 Hom_end-associated Hint ATP-synt_ab_Xtn PF16886.5 ORX71363.1 - 4.8e-44 149.1 0.0 9.5e-44 148.1 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension Hom_end PF05204.14 ORX71363.1 - 1.8e-39 134.3 0.0 2.8e-33 114.4 0.0 2.5 2 0 0 2 2 2 2 Homing endonuclease ATP-synt_ab_N PF02874.23 ORX71363.1 - 1.6e-13 50.9 1.6 3.7e-13 49.8 1.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LAGLIDADG_3 PF14528.6 ORX71363.1 - 2.2e-07 31.1 0.0 0.00019 21.6 0.0 2.8 2 0 0 2 2 2 2 LAGLIDADG-like domain DUF5300 PF17224.3 ORX71363.1 - 0.037 14.3 0.1 0.35 11.2 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) Hint PF01079.20 ORX71363.1 - 0.043 13.3 0.3 0.1 12.1 0.3 1.6 1 1 0 1 1 1 0 Hint module Mac PF12464.8 ORX71363.1 - 0.056 13.7 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Maltose acetyltransferase Hint_2 PF13403.6 ORX71363.1 - 0.47 10.7 2.2 0.78 10.0 0.0 2.6 3 0 0 3 3 3 0 Hint domain AAA PF00004.29 ORX71365.1 - 4.7e-41 140.3 0.0 8.8e-41 139.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX71365.1 - 4.3e-08 32.8 0.1 8.9e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX71365.1 - 1.2e-06 28.5 0.0 1.8e-05 24.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX71365.1 - 7.2e-05 23.1 0.0 0.0058 16.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX71365.1 - 0.0001 22.7 0.1 0.0021 18.5 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ORX71365.1 - 0.0012 18.9 0.0 0.0035 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX71365.1 - 0.0038 17.0 0.0 0.0099 15.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ORX71365.1 - 0.0062 16.1 0.1 0.024 14.2 0.0 2.0 2 1 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 ORX71365.1 - 0.01 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 ORX71365.1 - 0.014 15.1 0.2 0.078 12.7 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ORX71365.1 - 0.026 14.8 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX71365.1 - 0.028 14.8 0.0 0.081 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 ORX71365.1 - 0.032 14.1 0.8 7.8 6.3 0.0 3.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 ORX71365.1 - 0.033 13.4 0.1 0.096 11.9 0.0 1.8 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_33 PF13671.6 ORX71365.1 - 0.033 14.3 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ORX71365.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ORX71365.1 - 0.059 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ORX71365.1 - 0.066 13.8 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX71365.1 - 0.089 12.5 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ORX71365.1 - 0.16 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein UCH PF00443.29 ORX71366.1 - 3.6e-54 183.9 0.0 4.2e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX71366.1 - 9.9e-28 97.7 0.0 1.2e-27 97.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf_UBZ PF18439.1 ORX71366.1 - 1.4 8.5 3.7 3.6 7.3 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 ORX71366.1 - 1.5 9.4 8.2 4.3 7.9 0.6 3.0 3 0 0 3 3 3 0 Zinc-finger double domain zf-CHCC PF10276.9 ORX71367.1 - 3.2e-18 65.5 3.9 5e-18 64.9 3.9 1.3 1 0 0 1 1 1 1 Zinc-finger domain Ras PF00071.22 ORX71368.1 - 2e-62 209.6 0.1 2.7e-62 209.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX71368.1 - 2.8e-33 114.7 0.0 5.2e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX71368.1 - 2.7e-13 49.7 0.0 3.6e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX71368.1 - 5.8e-05 23.1 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX71368.1 - 0.001 18.5 0.0 0.0017 17.7 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX71368.1 - 0.0013 18.3 0.1 0.0071 15.9 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX71368.1 - 0.0014 18.6 0.1 0.51 10.2 0.0 2.6 1 1 2 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 ORX71368.1 - 0.0086 16.4 0.1 0.13 12.5 0.0 2.6 1 1 1 2 2 2 1 AAA domain DAP3 PF10236.9 ORX71368.1 - 0.053 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATP_bind_1 PF03029.17 ORX71368.1 - 0.076 12.8 0.0 0.82 9.4 0.0 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 ORX71368.1 - 0.082 12.6 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ORX71368.1 - 0.13 12.3 0.0 0.16 11.9 0.0 1.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 ORX71368.1 - 0.16 12.0 0.1 3 7.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LSM PF01423.22 ORX71369.1 - 1.2e-18 66.5 0.2 1.5e-18 66.3 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX71369.1 - 0.038 13.6 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Hfq protein Ribosomal_L14 PF00238.19 ORX71370.1 - 4.1e-35 120.5 0.1 4.8e-35 120.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Thioredoxin PF00085.20 ORX71371.1 - 0.00035 20.5 0.0 0.00052 20.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 ORX71372.1 - 9.9e-15 54.4 0.0 1.7e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ORX71372.1 - 0.0017 17.8 0.0 0.0028 17.1 0.0 1.5 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 ORX71372.1 - 0.0024 18.0 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ORX71372.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 ORX71372.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like DUF997 PF06196.12 ORX71372.1 - 0.3 11.1 1.3 0.4 10.7 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF997) MitMem_reg PF13012.6 ORX71373.1 - 2.4e-32 111.7 0.2 4.5e-32 110.8 0.2 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ORX71373.1 - 5.3e-32 110.3 0.0 8.9e-32 109.5 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease AMP-binding PF00501.28 ORX71374.1 - 3.1e-95 319.3 0.0 3.9e-95 318.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX71374.1 - 7.5e-13 49.3 0.0 2.6e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Kelch_4 PF13418.6 ORX71375.1 - 5.5e-12 45.5 7.3 2.9e-05 24.0 0.4 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX71375.1 - 2.1e-08 34.0 5.6 0.11 12.5 0.3 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ORX71375.1 - 1.1e-07 31.9 5.3 0.00055 20.1 0.4 4.0 3 1 1 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ORX71375.1 - 3.8e-07 30.2 12.9 0.00014 22.1 0.2 4.9 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX71375.1 - 7.8e-07 28.6 2.9 0.014 15.0 0.7 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ORX71375.1 - 9.9e-05 22.2 2.9 0.2 11.7 0.3 4.3 3 1 0 3 3 3 1 Kelch motif DUF3937 PF13073.6 ORX71375.1 - 0.15 12.2 0.3 0.69 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) TPX2 PF06886.11 ORX71377.1 - 1e-06 28.9 15.3 1e-06 28.9 15.3 5.1 5 1 1 6 6 6 2 Targeting protein for Xklp2 (TPX2) RRM_1 PF00076.22 ORX71378.1 - 0.038 13.8 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ORX71379.1 - 9.8e-09 34.9 0.0 8.4e-07 28.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ_C PF01556.18 ORX71380.1 - 1.8e-32 112.5 0.0 2.6e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX71380.1 - 7.7e-19 67.6 0.0 1.3e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX71380.1 - 2.8e-14 53.2 13.5 4.9e-14 52.4 13.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ORX71380.1 - 0.00052 19.9 10.8 0.0014 18.5 1.4 2.7 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ORX71380.1 - 0.16 12.0 5.2 0.92 9.6 1.2 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-HIT PF04438.16 ORX71380.1 - 0.27 11.1 3.0 0.67 9.9 3.0 1.7 1 0 0 1 1 1 0 HIT zinc finger Cytochrom_c3_2 PF14537.6 ORX71380.1 - 1.6 9.2 6.6 2.2 8.8 2.1 2.1 1 1 1 2 2 2 0 Cytochrome c3 zf-RING_10 PF16685.5 ORX71380.1 - 2.3 8.4 6.5 3 8.0 0.3 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Cytochrome_C7 PF14522.6 ORX71380.1 - 6.6 6.8 8.4 32 4.6 8.4 2.1 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c COX4 PF02936.14 ORX71381.1 - 3.2e-29 101.7 0.2 3.7e-29 101.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1043 PF06295.12 ORX71381.1 - 0.016 15.2 0.1 0.03 14.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) His_Phos_1 PF00300.22 ORX71381.1 - 0.046 13.4 0.0 0.06 13.0 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) UCH PF00443.29 ORX71382.1 - 2.6e-47 161.5 0.0 3.4e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX71382.1 - 1.3e-06 28.3 0.0 5.7e-05 22.8 0.0 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ORX71382.1 - 0.013 15.0 0.7 18 4.7 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Trypan_PARP PF05887.11 ORX71382.1 - 0.27 11.2 7.4 0.68 9.9 7.4 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SPT16 PF08644.11 ORX71383.1 - 4.3e-51 173.1 0.4 1.2e-50 171.6 0.0 2.1 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 ORX71383.1 - 3.1e-50 170.1 0.0 1.2e-49 168.2 0.0 2.1 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 ORX71383.1 - 4.4e-23 82.1 0.1 1.1e-22 80.8 0.0 1.6 2 0 0 2 2 2 1 Metallopeptidase family M24 Rtt106 PF08512.12 ORX71383.1 - 2e-16 60.1 0.1 5.3e-16 58.8 0.1 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like HLH PF00010.26 ORX71383.1 - 2.4 8.2 4.7 0.75 9.8 0.3 2.4 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain PhyH PF05721.13 ORX71384.1 - 7.3e-26 91.7 0.0 1e-25 91.2 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 ORX71384.1 - 0.0052 17.2 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase HD PF01966.22 ORX71385.1 - 3.4e-08 33.7 0.6 9.9e-08 32.2 0.6 1.7 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 ORX71385.1 - 2.1e-06 27.3 0.1 2.9e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 HDOD domain HD_4 PF13328.6 ORX71385.1 - 1.6e-05 24.7 1.2 2.3e-05 24.2 1.2 1.5 1 1 0 1 1 1 1 HD domain V-ATPase_H_C PF11698.8 ORX71385.1 - 0.022 14.9 0.0 0.087 12.9 0.0 1.9 2 1 0 2 2 2 0 V-ATPase subunit H LRR_8 PF13855.6 ORX71388.1 - 0.0014 18.3 0.1 0.017 14.9 0.0 2.8 2 0 0 2 2 2 1 Leucine rich repeat CRM1_C PF08767.11 ORX71389.1 - 3.5e-104 348.4 17.1 5.5e-103 344.5 11.8 3.7 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 ORX71389.1 - 1.4e-40 138.8 6.7 4.7e-40 137.1 4.6 2.9 2 1 0 2 2 2 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 ORX71389.1 - 7.9e-34 115.1 1.8 2.7e-33 113.4 1.8 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 ORX71389.1 - 3.6e-28 97.4 2.0 2.6e-27 94.7 2.0 2.7 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 ORX71389.1 - 3e-19 68.2 0.5 6.3e-19 67.2 0.5 1.6 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 ORX71389.1 - 6.3e-12 45.2 0.1 4.6e-11 42.5 0.3 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Brix PF04427.18 ORX71390.1 - 8.4e-39 133.7 0.3 1.1e-38 133.3 0.3 1.2 1 0 0 1 1 1 1 Brix domain Nucleopor_Nup85 PF07575.13 ORX71390.1 - 0.11 11.0 0.1 0.15 10.6 0.1 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin NCBP3 PF10309.9 ORX71392.1 - 0.0043 16.9 0.0 0.0076 16.1 0.0 1.6 1 1 0 1 1 1 1 Nuclear cap-binding protein subunit 3 FRG2 PF15315.6 ORX71392.1 - 0.46 10.7 4.5 10 6.3 0.5 2.1 1 1 1 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Ndc1_Nup PF09531.10 ORX71393.1 - 6.3e-70 236.6 0.3 1e-69 235.8 0.3 1.3 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup zf-RING_2 PF13639.6 ORX71394.1 - 2.2e-09 37.5 8.4 4.4e-09 36.5 8.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX71394.1 - 1.4e-07 31.2 7.2 2.6e-07 30.3 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX71394.1 - 1.8e-07 30.9 6.3 3.1e-07 30.2 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX71394.1 - 3.7e-07 30.1 4.9 6.6e-07 29.3 4.9 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX71394.1 - 6.8e-05 23.1 10.8 0.00042 20.5 10.8 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ORX71394.1 - 0.00011 22.0 5.1 0.00019 21.3 5.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX71394.1 - 0.00026 20.8 4.5 0.00049 19.9 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX71394.1 - 0.0016 18.2 2.5 0.0046 16.7 2.5 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ORX71394.1 - 0.0049 16.8 5.1 0.0093 15.9 5.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ORX71394.1 - 0.0078 15.8 3.3 0.019 14.6 3.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX71394.1 - 0.084 13.0 5.3 0.18 12.0 5.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 ORX71394.1 - 0.28 11.5 4.8 0.56 10.6 4.8 1.5 1 0 0 1 1 1 0 RING-like domain zf-ANAPC11 PF12861.7 ORX71394.1 - 0.33 11.0 7.9 1.6 8.8 6.2 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 ORX71394.1 - 0.77 9.9 3.8 0.6 10.3 1.8 1.8 2 0 0 2 2 1 0 KIAA1045 RING finger RINGv PF12906.7 ORX71394.1 - 2.7 8.2 6.1 8.8 6.6 6.1 1.9 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 ORX71394.1 - 4.9 7.4 6.0 14 5.9 6.0 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain BAG PF02179.16 ORX71395.1 - 9.2e-14 51.6 0.5 1.8e-13 50.7 0.5 1.5 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 ORX71395.1 - 8.6e-10 38.2 0.0 1.5e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ORX71395.1 - 0.014 15.8 0.0 0.043 14.3 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain Pox_A22 PF04848.13 ORX71395.1 - 0.027 14.6 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A22 protein Rad60-SLD_2 PF13881.6 ORX71395.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 ORX71395.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2205 PF10224.9 ORX71395.1 - 0.88 9.6 5.4 1.2 9.2 0.5 2.9 2 1 1 3 3 3 0 Short coiled-coil protein Peptidase_S9 PF00326.21 ORX71396.1 - 1.3e-21 77.1 0.0 2.1e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ORX71396.1 - 0.00017 21.4 1.2 0.41 10.2 1.0 2.4 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX71396.1 - 0.0009 18.6 0.6 0.036 13.3 0.0 2.2 1 1 0 2 2 2 1 Serine aminopeptidase, S33 PD40 PF07676.12 ORX71396.1 - 0.046 13.7 0.2 0.24 11.4 0.1 2.2 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF2920 PF11144.8 ORX71396.1 - 0.07 12.3 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) DLH PF01738.18 ORX71396.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family p450 PF00067.22 ORX71398.1 - 6.5e-27 94.4 0.0 7.6e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 E1-E2_ATPase PF00122.20 ORX71399.1 - 5.3e-50 169.4 0.9 5.3e-50 169.4 0.9 2.6 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX71399.1 - 8.8e-40 137.2 3.3 2.9e-37 129.0 1.9 3.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX71399.1 - 3.3e-25 88.3 0.0 8.5e-12 45.3 0.0 2.5 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ORX71399.1 - 3.9e-07 30.7 0.0 1e-06 29.3 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX71399.1 - 4.2e-06 26.7 0.4 0.0049 16.6 0.2 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ALMT PF11744.8 ORX71399.1 - 0.14 10.9 0.5 0.3 9.9 0.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter EccE PF11203.8 ORX71399.1 - 3 8.2 6.9 5.8 7.3 0.0 4.0 4 0 0 4 4 4 0 Putative type VII ESX secretion system translocon, EccE Solute_trans_a PF03619.16 ORX71401.1 - 5e-93 311.5 8.6 5.9e-93 311.2 8.6 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha TGT PF01702.18 ORX71402.1 - 4.1e-57 193.9 0.2 2e-42 145.6 0.2 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase Tht1 PF04163.12 ORX71402.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein MSL2-CXC PF16682.5 ORX71402.1 - 3.2 7.9 9.3 0.11 12.7 2.9 1.8 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 COX6B PF02297.17 ORX71403.1 - 8.6e-14 51.5 4.8 9.9e-14 51.3 4.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.13 ORX71403.1 - 0.055 13.6 1.1 0.15 12.2 1.1 1.8 1 1 0 1 1 1 0 CHCH domain UCR_hinge PF02320.16 ORX71403.1 - 0.061 13.5 1.2 0.19 12.0 0.1 1.9 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Vps35 PF03635.17 ORX71404.1 - 8.8e-211 702.2 0.0 4.3e-80 270.2 0.0 3.0 1 1 2 3 3 3 3 Vacuolar protein sorting-associated protein 35 PA26 PF04636.13 ORX71404.1 - 0.12 11.3 1.1 0.19 10.6 1.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF758 PF05527.11 ORX71404.1 - 0.12 12.4 0.9 0.28 11.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF758) BUD22 PF09073.10 ORX71404.1 - 0.42 9.9 20.5 0.7 9.2 20.5 1.2 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 ORX71404.1 - 0.84 8.6 7.3 1.6 7.6 7.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 ORX71404.1 - 1.4 7.6 6.6 2.3 6.9 6.6 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RRN3 PF05327.11 ORX71404.1 - 1.6 7.1 8.0 2.9 6.3 8.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 ORX71404.1 - 2.4 7.3 4.1 4.1 6.5 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Striatin PF08232.12 ORX71404.1 - 3 8.4 15.8 4.3 7.9 9.3 3.1 3 0 0 3 3 3 0 Striatin family AIF_C PF14721.6 ORX71404.1 - 3.3 8.1 10.0 19 5.6 10.0 2.1 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term ERCC3_RAD25_C PF16203.5 ORX71405.1 - 2e-121 403.9 0.7 5.8e-121 402.4 0.1 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ORX71405.1 - 4.8e-13 49.5 0.0 9.2e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX71405.1 - 9.9e-13 48.4 0.0 2.4e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ORX71405.1 - 4.9e-08 32.1 0.3 9.4e-08 31.1 0.2 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 ORX71405.1 - 0.00043 20.1 0.1 0.00088 19.1 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4460 PF14687.6 ORX71406.1 - 0.13 12.3 0.1 0.3 11.2 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) DUF2706 PF10913.8 ORX71407.1 - 0.18 11.6 0.8 0.65 9.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2706) E1-E2_ATPase PF00122.20 ORX71408.1 - 4.5e-50 169.7 0.8 4.5e-50 169.7 0.8 2.6 1 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX71408.1 - 3e-19 70.1 2.2 4.3e-09 37.0 0.0 4.2 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase HMA PF00403.26 ORX71408.1 - 5.5e-18 65.2 0.1 7.9e-12 45.4 0.0 2.6 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ORX71408.1 - 0.0034 17.2 0.2 0.0072 16.1 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF996 PF06195.13 ORX71408.1 - 2 8.7 9.2 0.16 12.3 2.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF996) Peptidase_C14 PF00656.22 ORX71409.1 - 4.3e-58 197.2 0.2 5.9e-58 196.7 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 ORX71409.1 - 0.69 9.9 3.5 1.2 9.0 0.9 2.7 2 1 0 2 2 2 0 Raptor N-terminal CASPase like domain Pex14_N PF04695.13 ORX71409.1 - 2.2 8.9 8.4 42 4.8 9.3 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gpr1_Fun34_YaaH PF01184.19 ORX71410.1 - 2.9e-52 177.3 20.0 3.2e-52 177.1 20.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF707 PF05212.12 ORX71410.1 - 0.18 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF707) DUF3040 PF11239.8 ORX71410.1 - 1.1 9.6 8.1 1.9 8.8 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) SEP PF08059.13 ORX71411.1 - 3.3e-24 85.3 0.0 1.1e-23 83.6 0.0 1.9 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 ORX71411.1 - 3.2e-12 46.5 0.0 7.4e-12 45.3 0.0 1.6 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.6 ORX71411.1 - 1.8e-10 40.5 0.3 3.7e-10 39.4 0.3 1.5 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ORX71411.1 - 0.004 16.8 0.4 0.007 16.0 0.4 1.3 1 0 0 1 1 1 1 TAP C-terminal domain Patatin PF01734.22 ORX71413.1 - 0.00098 19.3 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase PGAP1 PF07819.13 ORX71414.1 - 7e-08 32.5 0.0 1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 ORX71414.1 - 1e-06 28.8 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 ORX71414.1 - 2.7e-05 23.9 0.1 0.0055 16.4 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF676 PF05057.14 ORX71414.1 - 3.7e-05 23.3 0.0 7.2e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 ORX71414.1 - 0.00017 20.9 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 ORX71414.1 - 0.0015 17.9 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 ORX71414.1 - 0.019 15.6 0.1 0.034 14.7 0.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 ORX71414.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Lipase_2 PF01674.18 ORX71414.1 - 0.034 13.7 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) TetR_C_7 PF14246.6 ORX71414.1 - 0.047 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain Hydrolase_4 PF12146.8 ORX71414.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Cullin_binding PF03556.15 ORX71415.1 - 3.1e-16 59.9 0.0 4.8e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Cullin binding DUF4846 PF16138.5 ORX71415.1 - 0.093 12.2 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (4846) PLA2_B PF01735.18 ORX71416.1 - 8.6e-32 110.2 0.0 1.3e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 Lysophospholipase catalytic domain SDH_alpha PF03313.15 ORX71417.1 - 2.1e-79 266.9 2.4 1.1e-52 179.3 5.0 2.2 2 0 0 2 2 2 2 Serine dehydratase alpha chain SDH_beta PF03315.15 ORX71417.1 - 3.5e-59 199.6 0.4 9.5e-59 198.2 0.0 1.9 2 0 0 2 2 2 1 Serine dehydratase beta chain Sec1 PF00995.23 ORX71418.1 - 8.1e-14 51.8 0.0 1e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 Sec1 family F-box-like PF12937.7 ORX71419.1 - 3.6e-13 49.2 0.9 1.1e-12 47.6 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX71419.1 - 4.8e-11 42.2 2.1 5.6e-11 42.0 0.1 2.2 2 0 0 2 2 2 1 F-box domain PP2 PF14299.6 ORX71419.1 - 4.5e-06 26.8 0.0 9.7e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Phloem protein 2 F-box_4 PF15966.5 ORX71419.1 - 0.00024 21.0 0.2 0.00053 19.9 0.0 1.6 2 0 0 2 2 2 1 F-box F-box_5 PF18511.1 ORX71419.1 - 0.035 13.7 0.5 0.13 11.8 0.1 2.2 2 0 0 2 2 2 0 F-box Sec1 PF00995.23 ORX71420.1 - 2.2e-101 340.9 0.0 3.8e-101 340.1 0.0 1.4 1 0 0 1 1 1 1 Sec1 family Imm59 PF15597.6 ORX71420.1 - 0.0029 18.1 0.1 0.0063 17.0 0.1 1.5 1 0 0 1 1 1 1 Immunity protein 59 GRP PF07172.11 ORX71420.1 - 0.16 12.7 15.6 0.042 14.5 11.6 2.1 2 0 0 2 2 2 0 Glycine rich protein family Cyclin_N PF00134.23 ORX71423.1 - 2.2e-08 33.9 0.0 2.6e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX71423.1 - 2.3e-06 28.0 0.0 2.8e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Cyclin RasGEF PF00617.19 ORX71424.1 - 7e-17 62.2 0.1 1.2e-16 61.5 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain Kinesin PF00225.23 ORX71425.1 - 2.7e-88 296.1 0.0 1.6e-87 293.6 0.0 1.8 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX71425.1 - 3.8e-19 69.1 0.0 6e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding KASH_CCD PF14662.6 ORX71426.1 - 0.00049 20.0 55.5 0.02 14.7 12.8 3.5 3 0 0 3 3 3 3 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 ORX71426.1 - 0.00055 19.3 14.2 0.00055 19.3 14.2 5.2 3 2 2 5 5 5 2 Growth-arrest specific micro-tubule binding ZapB PF06005.12 ORX71426.1 - 0.012 16.1 8.3 0.012 16.1 8.3 6.5 3 3 3 6 6 6 0 Cell division protein ZapB DUF2433 PF10360.9 ORX71426.1 - 0.31 11.2 1.5 1.4 9.1 1.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) Fez1 PF06818.15 ORX71426.1 - 0.33 11.4 64.6 0.41 11.1 15.4 4.5 2 2 3 5 5 5 0 Fez1 YabA PF06156.13 ORX71426.1 - 1.8 9.3 41.7 1.7 9.3 4.7 5.8 3 3 3 6 6 6 0 Initiation control protein YabA FapA PF03961.13 ORX71426.1 - 3.1 6.3 32.5 0.2 10.2 6.9 3.2 3 0 0 3 3 3 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 ORX71426.1 - 4.2 7.8 0.0 4.2 7.8 0.0 7.0 4 3 2 7 7 7 0 Flagella accessory protein C (FlaC) GalKase_gal_bdg PF10509.9 ORX71427.1 - 1.7e-19 69.1 0.1 3.3e-19 68.2 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 ORX71427.1 - 1.1e-14 54.5 0.0 2.4e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 ORX71427.1 - 3.5e-11 43.2 0.9 8.1e-11 42.0 0.9 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 ORX71428.1 - 4.6e-18 64.5 0.1 1e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 ORX71428.1 - 3.9e-15 56.0 0.0 4.7e-14 52.5 0.0 2.7 3 0 0 3 3 3 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 ORX71428.1 - 1.9e-13 50.4 0.6 6.5e-13 48.7 0.6 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain DnaJ PF00226.31 ORX71429.1 - 4.4e-20 71.6 0.1 6.5e-20 71.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 ORX71429.1 - 0.039 14.2 2.2 0.055 13.8 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Cation_efflux PF01545.21 ORX71430.1 - 1.1e-17 64.5 9.8 1.4e-17 64.1 9.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ORX71430.1 - 6.5e-07 29.4 0.3 1.2e-06 28.6 0.3 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF5426 PF17473.2 ORX71430.1 - 0.082 13.2 1.0 0.63 10.3 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5426) DUF4451 PF14616.6 ORX71431.1 - 3.8e-10 40.0 4.6 8.7e-10 38.9 4.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4451) WD40_4 PF16300.5 ORX71431.1 - 0.0075 16.1 0.5 0.022 14.7 0.0 2.1 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 ORX71432.1 - 5.5e-39 131.4 28.4 7.8e-07 29.7 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX71432.1 - 2.1e-09 37.5 2.0 0.027 14.8 0.0 4.8 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX71432.1 - 9.2e-07 27.9 11.1 0.39 9.3 0.4 5.2 2 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX71432.1 - 0.00033 20.1 0.2 0.053 12.8 0.0 2.7 1 1 0 2 2 2 1 WD40-like domain DUF5046 PF16465.5 ORX71432.1 - 0.00093 18.7 0.3 0.85 9.0 0.0 3.5 1 1 2 3 3 3 1 Domain of unknown function (DUF5046) BRK PF07533.16 ORX71432.1 - 0.0011 18.6 0.0 0.26 10.9 0.0 3.7 4 0 0 4 4 4 1 BRK domain PQQ_2 PF13360.6 ORX71432.1 - 0.0011 18.5 2.2 0.023 14.3 0.7 2.8 1 1 2 3 3 3 2 PQQ-like domain FlaG PF03646.15 ORX71432.1 - 0.021 15.0 0.2 40 4.5 0.0 3.8 4 0 0 4 4 4 0 FlaG protein Frtz PF11768.8 ORX71432.1 - 0.048 12.0 0.1 0.27 9.5 0.0 2.0 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PH PF00169.29 ORX71433.1 - 1.1e-06 29.1 0.1 3e-06 27.7 0.1 1.7 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ORX71433.1 - 0.0041 17.5 0.1 0.013 15.9 0.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 ORX71433.1 - 0.04 13.7 0.0 0.091 12.6 0.0 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain PH_15 PF17339.2 ORX71433.1 - 0.041 13.8 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 PH domain Arm PF00514.23 ORX71434.1 - 6.9e-53 175.2 20.2 4.6e-12 45.5 0.1 10.5 11 0 0 11 11 11 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX71434.1 - 7.2e-11 42.3 4.4 0.015 15.7 0.2 6.3 2 1 4 6 6 6 4 HEAT repeats HEAT_EZ PF13513.6 ORX71434.1 - 3.4e-10 40.2 8.5 0.028 14.9 0.1 6.7 5 1 3 8 8 7 5 HEAT-like repeat KAP PF05804.12 ORX71434.1 - 2.6e-09 35.8 0.7 3.5e-09 35.4 0.7 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Adaptin_N PF01602.20 ORX71434.1 - 4.7e-06 25.4 5.5 0.0077 14.8 0.4 2.5 1 1 0 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 ORX71434.1 - 1.4e-05 24.7 3.3 0.069 12.6 0.3 2.8 1 1 2 3 3 3 2 Armadillo-like V-ATPase_H_N PF03224.14 ORX71434.1 - 0.00027 20.4 0.6 0.0062 15.9 0.2 2.7 1 1 1 2 2 2 1 V-ATPase subunit H PUL PF08324.11 ORX71434.1 - 0.0011 18.2 5.3 0.94 8.7 0.2 3.3 1 1 1 3 3 3 2 PUL domain IFRD PF05004.13 ORX71434.1 - 0.0019 17.4 3.1 0.67 9.0 0.1 3.5 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) DUF5578 PF17741.1 ORX71434.1 - 0.0078 15.7 1.5 2.9 7.2 0.0 3.3 1 1 0 2 2 2 2 Family of unknown function (DUF5578) Cnd1 PF12717.7 ORX71434.1 - 0.0097 16.0 2.0 0.15 12.1 0.1 3.0 1 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX71434.1 - 1.1 9.7 18.0 21 5.7 0.0 8.0 10 1 1 11 11 11 0 HEAT repeat Not3 PF04065.15 ORX71435.1 - 2.6e-82 275.7 25.2 3.8e-82 275.2 25.2 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 ORX71435.1 - 9.9e-40 135.7 7.0 9.9e-40 135.7 7.0 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Xrn1_D3 PF18194.1 ORX71435.1 - 0.27 11.4 2.7 0.87 9.7 0.1 2.7 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 TPP_enzyme_M PF00205.22 ORX71436.1 - 0.051 13.3 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain OTU PF02338.19 ORX71437.1 - 3.8e-05 24.2 0.0 6.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease ubiquitin PF00240.23 ORX71437.1 - 0.016 14.9 0.0 0.22 11.3 0.0 2.6 2 1 0 2 2 2 0 Ubiquitin family Peptidase_C65 PF10275.9 ORX71437.1 - 0.022 14.2 0.0 1.3 8.4 0.0 2.3 1 1 1 2 2 2 0 Peptidase C65 Otubain GTP_EFTU PF00009.27 ORX71438.1 - 1.6e-41 142.0 0.0 4.1e-41 140.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX71438.1 - 4.2e-33 114.0 0.1 1.3e-32 112.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX71438.1 - 3.2e-10 40.2 0.1 8.9e-10 38.8 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX71438.1 - 0.0088 16.1 0.1 0.052 13.6 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase GCP_N_terminal PF17681.1 ORX71439.1 - 3.4e-69 233.8 0.0 7.7e-69 232.6 0.0 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ORX71439.1 - 5.6e-35 121.3 0.0 1e-34 120.4 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Ribosomal_L28e PF01778.17 ORX71440.1 - 4.8e-34 117.5 0.0 4.8e-34 117.5 0.0 2.3 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.14 ORX71440.1 - 4.4e-26 91.4 17.9 4.4e-26 91.4 17.9 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 ORX71440.1 - 2.5e-05 23.8 19.4 3.1e-05 23.5 19.4 1.1 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 ORX71440.1 - 5 5.2 34.3 6.8 4.8 34.3 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 ORX71440.1 - 8.2 5.1 13.1 11 4.7 13.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pkinase_fungal PF17667.1 ORX71441.1 - 9.2e-58 195.9 0.3 3.2e-29 101.9 0.0 2.6 2 1 1 3 3 3 2 Fungal protein kinase Pkinase PF00069.25 ORX71441.1 - 0.00064 19.2 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 ORX71441.1 - 0.026 14.1 0.1 0.07 12.7 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 ORX71442.1 - 7e-53 179.9 0.0 3.4e-29 101.9 0.0 3.7 2 2 1 4 4 4 2 Fungal protein kinase Pkinase PF00069.25 ORX71442.1 - 1.2e-06 28.1 0.0 5.8e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 ORX71442.1 - 0.03 13.9 0.0 0.074 12.6 0.0 1.6 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ORX71442.1 - 0.063 13.2 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX71442.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF533 PF04391.12 ORX71442.1 - 0.25 10.9 3.8 2.1 7.9 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF533) Arg_repressor PF01316.21 ORX71443.1 - 0.013 15.2 0.4 0.027 14.2 0.0 1.7 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain UPF0016 PF01169.19 ORX71444.1 - 5.5e-44 148.4 24.3 6.6e-22 77.6 11.6 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 OFeT_1 PF16955.5 ORX71444.1 - 1.8e-05 24.5 1.2 5e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron uptake permease, iron-lead transporter Nitrate_red_gam PF02665.14 ORX71444.1 - 0.37 10.3 7.6 0.82 9.2 1.5 2.3 2 0 0 2 2 2 0 Nitrate reductase gamma subunit LysE PF01810.18 ORX71444.1 - 0.4 10.1 20.0 2.5 7.5 5.7 3.3 2 2 1 3 3 3 0 LysE type translocator Sld7_C PF18596.1 ORX71445.1 - 4.7e-08 33.0 0.1 8.3e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Sld7 C-terminal domain ADK PF00406.22 ORX71446.1 - 1.7e-48 164.5 0.0 2e-48 164.3 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX71446.1 - 4.4e-20 72.5 0.0 7.9e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ORX71446.1 - 5.7e-13 48.6 0.2 9.1e-13 48.0 0.2 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ORX71446.1 - 0.0032 18.0 0.0 0.0051 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX71446.1 - 0.02 15.1 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 ORX71446.1 - 0.037 14.3 0.9 0.13 12.5 0.1 1.8 1 1 0 2 2 2 0 Hydin Adenylate kinase-like domain Pkinase PF00069.25 ORX71447.1 - 5e-73 245.7 0.0 6.6e-73 245.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71447.1 - 1.2e-28 100.1 0.0 3.3e-20 72.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX71447.1 - 2.4e-09 37.0 0.5 0.022 14.1 0.1 3.1 2 1 1 3 3 3 3 Kinase-like APH PF01636.23 ORX71447.1 - 0.0013 18.7 0.0 0.33 10.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX71447.1 - 0.013 14.3 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ORX71447.1 - 0.022 14.1 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX71447.1 - 0.05 12.5 0.0 0.19 10.7 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain zf-C2H2 PF00096.26 ORX71449.1 - 1.9e-08 34.3 14.1 1.9e-07 31.2 1.6 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX71449.1 - 1.8e-07 31.2 2.7 1.8e-07 31.2 2.7 3.1 3 1 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX71449.1 - 2e-06 27.9 0.1 2e-06 27.9 0.1 2.4 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX71449.1 - 2.2e-06 28.0 1.6 2.2e-06 28.0 1.6 3.1 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX71449.1 - 0.00074 19.5 0.5 0.00074 19.5 0.5 1.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 ORX71449.1 - 0.00088 19.6 0.6 0.0017 18.7 0.1 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ORX71449.1 - 0.45 10.9 4.9 12 6.3 4.9 2.2 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 ORX71449.1 - 3.1 8.5 7.6 1.1 9.9 0.5 2.7 2 1 1 3 3 3 0 FOXP coiled-coil domain RSRP PF17069.5 ORX71450.1 - 0.078 12.6 16.8 0.11 12.0 16.8 1.1 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Fungal_trans PF04082.18 ORX71451.1 - 1.3e-08 34.3 0.1 2.1e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX71451.1 - 7.6e-06 25.9 14.3 1.2e-05 25.3 14.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5367 PF17329.2 ORX71451.1 - 0.022 14.8 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5367) Fungal_trans PF04082.18 ORX71452.1 - 2.4e-12 46.5 2.0 1.3e-11 44.0 2.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain TetR_C_22 PF17928.1 ORX71452.1 - 0.047 14.0 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain STAG PF08514.11 ORX71452.1 - 0.11 12.4 0.2 2 8.3 0.0 2.3 2 0 0 2 2 2 0 STAG domain Ribosomal_L12 PF00542.19 ORX71453.1 - 1.1e-17 64.1 14.7 5.9e-17 61.8 10.2 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 ORX71453.1 - 7.2e-14 51.2 11.5 7.2e-14 51.2 11.5 2.8 4 1 0 4 4 4 1 Ribosomal protein L7/L12 dimerisation domain Methyltransf_34 PF11312.8 ORX71453.1 - 0.0068 15.7 0.4 0.0078 15.5 0.4 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Ribosomal_60s PF00428.19 ORX71453.1 - 0.013 16.0 12.7 0.013 16.0 12.7 2.8 1 1 1 3 3 3 0 60s Acidic ribosomal protein Dor1 PF04124.12 ORX71453.1 - 0.034 12.8 0.1 0.061 12.0 0.1 1.3 1 0 0 1 1 1 0 Dor1-like family RasGAP PF00616.19 ORX71454.1 - 8.3e-11 42.0 0.1 4.4e-07 29.8 0.2 2.6 2 1 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase RNA12 PF10443.9 ORX71456.1 - 1.2e-83 281.4 0.4 1.9e-46 158.7 0.1 3.1 1 1 2 3 3 3 3 RNA12 protein RRM_1 PF00076.22 ORX71456.1 - 3.2e-05 23.6 0.0 7.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 ORX71456.1 - 0.00031 20.7 0.0 0.0008 19.4 0.0 1.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ORX71456.1 - 0.00051 20.5 0.0 0.0017 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 ORX71456.1 - 0.0066 15.5 0.0 0.02 14.0 0.0 1.7 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ORX71456.1 - 0.0085 16.4 0.0 0.034 14.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ORX71456.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF2076 PF09849.9 ORX71456.1 - 0.14 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) AAA PF00004.29 ORX71456.1 - 0.16 12.4 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ThiF PF00899.21 ORX71457.1 - 2e-14 53.5 0.1 7.6e-07 28.7 0.0 2.3 1 1 1 2 2 2 2 ThiF family 4HBT_3 PF13622.6 ORX71458.1 - 4.1e-47 161.5 0.8 7.3e-46 157.4 0.8 2.0 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX71458.1 - 5.4e-30 103.9 0.0 1.6e-25 89.5 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase SANT_DAMP1_like PF16282.5 ORX71460.1 - 8.3e-27 93.2 2.4 1.9e-26 92.1 2.4 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 ORX71460.1 - 1.2e-05 25.3 2.9 0.0011 18.9 0.0 2.9 3 0 0 3 3 3 2 DNA methyltransferase 1-associated protein 1 (DMAP1) PRELI PF04707.14 ORX71461.1 - 1.7e-45 154.7 0.1 2e-45 154.4 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family Cyclin_N PF00134.23 ORX71461.1 - 0.092 12.5 0.1 0.27 11.0 0.0 1.7 2 0 0 2 2 2 0 Cyclin, N-terminal domain Calreticulin PF00262.18 ORX71462.1 - 1.1e-146 488.4 3.3 1.4e-146 488.1 3.3 1.0 1 0 0 1 1 1 1 Calreticulin family Hid1 PF12722.7 ORX71463.1 - 1.6e-166 555.8 0.0 1.9e-165 552.2 0.0 2.1 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ORX71463.1 - 1.5e-78 264.8 0.0 1.8e-78 264.5 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein KH_1 PF00013.29 ORX71464.1 - 6.8e-38 128.3 7.2 1.2e-16 60.3 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ORX71464.1 - 6.5e-10 38.7 11.1 0.0076 16.0 0.1 3.8 3 1 1 4 4 4 3 KH domain KH_4 PF13083.6 ORX71464.1 - 7.4e-10 38.6 2.6 0.011 15.6 0.1 3.6 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 ORX71464.1 - 0.00031 20.8 9.1 0.014 15.5 0.2 3.7 4 0 0 4 4 4 2 NusA-like KH domain PDH PF02153.17 ORX71464.1 - 0.0072 15.4 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase dUTPase PF00692.19 ORX71464.1 - 0.074 12.7 0.1 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 dUTPase EAP30 PF04157.16 ORX71466.1 - 1.9e-29 102.6 0.0 3.8e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 ORX71466.1 - 3.3e-22 78.5 0.0 5.4e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-RanBP PF00641.18 ORX71466.1 - 0.00069 18.9 10.9 0.019 14.3 1.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others GlutR_dimer PF00745.20 ORX71466.1 - 0.19 12.2 0.3 0.44 11.0 0.3 1.5 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain Vps36-NZF-N PF16988.5 ORX71466.1 - 1.8 8.0 13.4 5.7 6.4 5.2 3.1 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 ORX71466.1 - 2.3 8.3 8.3 5.7 7.1 8.3 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-Sec23_Sec24 PF04810.15 ORX71466.1 - 7.4 6.7 11.9 1.2 9.3 0.2 3.3 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger Zf_RING PF16744.5 ORX71466.1 - 9.8 6.4 8.7 4.2 7.5 0.1 2.7 1 1 0 2 2 2 0 KIAA1045 RING finger Fungal_trans PF04082.18 ORX71467.1 - 2e-30 105.7 0.2 4.7e-30 104.5 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX71467.1 - 9.4e-11 41.7 11.5 1.9e-10 40.7 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM234 PF10639.9 ORX71469.1 - 2.2e-27 95.4 2.2 8.5e-26 90.3 2.2 2.0 1 1 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 ORX71469.1 - 5.6e-07 29.8 4.0 6.6e-07 29.6 4.0 1.1 1 0 0 1 1 1 1 EamA-like transporter family EmrE PF13536.6 ORX71469.1 - 0.0015 18.2 0.3 0.0016 18.1 0.3 1.1 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter RseC_MucC PF04246.12 ORX71469.1 - 1.3 9.0 4.1 3.2 7.7 1.8 2.0 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Nop16 PF09420.10 ORX71470.1 - 7.8e-21 75.1 3.0 8.4e-21 75.0 3.0 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Enkurin PF13864.6 ORX71470.1 - 0.046 14.2 3.7 0.057 13.9 3.7 1.1 1 0 0 1 1 1 0 Calmodulin-binding Tudor_1_RapA PF18339.1 ORX71470.1 - 0.049 13.6 0.1 3.7 7.6 0.0 2.2 2 0 0 2 2 2 0 RapA N-terminal Tudor like domain 1 DUF1748 PF08520.10 ORX71470.1 - 0.13 12.2 0.2 0.26 11.2 0.2 1.6 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF1748) UQ_con PF00179.26 ORX71471.1 - 1.7e-49 167.0 0.0 2e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme CH PF00307.31 ORX71472.1 - 1.3e-26 92.9 0.0 1.6e-16 60.4 0.0 3.4 1 1 2 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 ORX71472.1 - 5.3e-09 36.1 0.0 6.6e-08 32.5 0.0 2.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_6 PF13405.6 ORX71472.1 - 0.006 16.4 0.3 0.02 14.8 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 ORX71472.1 - 0.032 14.1 0.1 0.083 12.8 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair LRR_4 PF12799.7 ORX71473.1 - 4.6e-10 39.6 5.8 4.6e-07 30.1 1.6 1.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX71473.1 - 1.6e-08 34.2 1.7 1.8e-08 34.0 1.7 1.1 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 ORX71473.1 - 0.00087 19.5 0.9 0.74 10.6 0.2 2.3 2 0 0 2 2 2 2 Leucine Rich Repeat LRR_9 PF14580.6 ORX71473.1 - 0.0049 16.4 0.3 0.0049 16.4 0.3 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 ORX71473.1 - 0.51 10.5 9.1 1.9 8.7 0.1 2.5 3 0 0 3 3 3 0 Leucine Rich repeat PH PF00169.29 ORX71475.1 - 1.6e-33 115.4 6.4 7.3e-20 71.4 0.2 2.2 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ORX71475.1 - 5.4e-10 39.6 13.7 7.8e-05 23.1 5.6 3.5 2 2 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 ORX71475.1 - 1.2e-08 34.9 3.6 0.0043 17.1 1.3 2.8 2 1 0 2 2 2 2 PH domain PH_8 PF15409.6 ORX71475.1 - 7.7e-07 29.3 9.7 0.0094 16.2 0.2 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_15 PF17339.2 ORX71475.1 - 7.2e-05 22.6 1.0 0.0067 16.3 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 ORX71475.1 - 0.00032 21.0 0.7 0.004 17.5 0.1 2.2 2 0 0 2 2 2 1 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 ORX71475.1 - 0.004 17.3 3.4 2 8.6 0.0 2.4 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology BCL_N PF04714.13 ORX71475.1 - 0.011 15.8 2.1 3.7 7.7 0.1 2.7 2 0 0 2 2 2 0 BCL7, N-terminal conserver region PH_9 PF15410.6 ORX71475.1 - 0.02 15.2 6.0 0.037 14.4 0.4 3.0 2 2 0 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.5 ORX71475.1 - 0.029 14.2 2.0 0.036 13.9 0.1 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain TRAM1 PF08390.11 ORX71476.1 - 3.5e-05 23.4 0.1 7.7e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 ORX71476.1 - 0.00043 20.1 0.1 0.00091 19.0 0.1 1.5 1 1 0 1 1 1 1 TLC domain TRAM_LAG1_CLN8 PF03798.16 ORX71477.1 - 8.2e-32 110.5 17.9 1.2e-31 110.0 12.6 2.2 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 ORX71477.1 - 4.1e-14 52.0 0.1 9.4e-14 50.8 0.1 1.6 1 0 0 1 1 1 1 TRAM1-like protein MMS1_N PF10433.9 ORX71478.1 - 8.4e-09 34.6 0.1 2.1e-05 23.4 0.0 2.2 1 1 0 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX71478.1 - 9.8e-05 21.8 0.0 1.6 8.0 0.0 4.4 2 1 2 4 4 4 3 CPSF A subunit region eIF3_subunit PF08597.10 ORX71479.1 - 3.9e-47 161.2 30.1 1.1e-46 159.7 30.1 1.6 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit IBN_N PF03810.19 ORX71480.1 - 1.7e-15 56.7 1.9 2e-14 53.3 0.1 3.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cse1 PF08506.10 ORX71480.1 - 6.6e-09 35.1 0.0 1.2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Cse1 RTP1_C1 PF10363.9 ORX71480.1 - 0.026 14.7 0.2 0.3 11.3 0.0 2.9 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Coat_F PF07875.12 ORX71480.1 - 0.42 10.9 1.7 3.5 7.9 0.1 2.9 3 0 0 3 3 3 0 Coat F domain Ribosom_S12_S23 PF00164.25 ORX71481.1 - 1.4e-50 169.6 0.4 1.8e-50 169.3 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 VWA_2 PF13519.6 ORX71482.1 - 2.8e-13 50.5 0.0 1.6e-12 48.0 0.0 2.2 1 1 2 3 3 3 1 von Willebrand factor type A domain UIM PF02809.20 ORX71482.1 - 1.5e-08 34.0 11.3 8.8e-05 22.2 2.8 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif Ssl1 PF04056.14 ORX71482.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 Ssl1-like adh_short PF00106.25 ORX71483.1 - 1.3e-18 67.1 0.0 9e-18 64.4 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX71483.1 - 7.4e-12 45.3 0.0 8.4e-11 41.9 0.0 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1180 PF06679.12 ORX71484.1 - 1.1 9.7 11.4 7.2 7.0 11.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) SpoIIE PF07228.12 ORX71485.1 - 1.4e-10 41.4 0.5 2.6e-10 40.5 0.5 1.4 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ORX71485.1 - 1.1e-07 31.8 0.1 0.0003 20.5 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ORX71485.1 - 0.00021 21.0 2.9 0.012 15.2 1.8 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C Importin_rep_6 PF18829.1 ORX71485.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Importin repeat 6 FAD-oxidase_C PF02913.19 ORX71486.1 - 5.3e-64 216.3 0.0 7e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX71486.1 - 2.3e-37 127.9 0.7 4.3e-37 126.9 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain AAA PF00004.29 ORX71487.1 - 2.5e-16 60.3 0.0 7.1e-16 58.8 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ORX71487.1 - 2.6e-12 46.8 0.0 2.3e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 ORX71487.1 - 3.3e-11 43.4 0.3 8.8e-11 42.1 0.2 1.8 1 1 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 ORX71487.1 - 5.4e-07 29.7 0.0 1.7e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 ORX71487.1 - 5.4e-05 23.0 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX71487.1 - 7.9e-05 23.1 1.4 0.0011 19.4 1.4 2.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 ORX71487.1 - 0.00011 22.1 0.0 0.00031 20.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX71487.1 - 0.00012 21.9 0.3 0.002 17.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 ORX71487.1 - 0.00014 22.1 0.1 0.00039 20.7 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_24 PF13479.6 ORX71487.1 - 0.00062 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX71487.1 - 0.00071 19.9 0.1 0.22 11.8 0.0 2.6 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 ORX71487.1 - 0.0018 18.3 0.0 0.021 14.8 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF815 PF05673.13 ORX71487.1 - 0.0019 17.4 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ORX71487.1 - 0.002 18.2 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 ORX71487.1 - 0.0022 17.8 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 ORX71487.1 - 0.0023 17.9 0.0 0.0077 16.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX71487.1 - 0.0063 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_25 PF13481.6 ORX71487.1 - 0.01 15.4 0.4 0.14 11.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ORX71487.1 - 0.011 15.1 0.2 0.31 10.4 0.1 2.5 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 ORX71487.1 - 0.015 14.7 0.1 0.49 9.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 ORX71487.1 - 0.018 15.3 0.1 0.27 11.6 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX71487.1 - 0.023 15.2 0.0 0.063 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX71487.1 - 0.025 14.8 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ORX71487.1 - 0.086 12.7 0.0 0.28 11.1 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ORX71487.1 - 0.1 12.0 0.1 1.3 8.4 0.0 2.5 3 0 0 3 3 3 0 Bacterial TniB protein RNA_helicase PF00910.22 ORX71487.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.29 ORX71487.1 - 0.13 12.0 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF2075 PF09848.9 ORX71487.1 - 0.19 11.0 0.0 1.3 8.2 0.0 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 ORX71487.1 - 0.23 10.5 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RRM_1 PF00076.22 ORX71488.1 - 1.1e-15 57.2 0.0 1.7e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ORX71488.1 - 1.7e-08 34.1 2.6 3e-08 33.3 2.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 ORX71488.1 - 1.5e-05 24.7 2.1 2.4e-05 24.1 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 ORX71488.1 - 0.0002 21.0 3.6 0.0005 19.7 3.6 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 ORX71488.1 - 0.0013 18.7 0.2 0.0038 17.1 0.2 1.8 1 0 0 1 1 1 1 Zinc knuckle RRM_3 PF08777.11 ORX71488.1 - 0.014 15.4 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RSRP PF17069.5 ORX71488.1 - 0.21 11.1 38.9 0.28 10.7 38.9 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Hpt PF01627.23 ORX71489.1 - 2.5e-10 40.5 0.1 3.7e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Hpt domain Vps52 PF04129.12 ORX71491.1 - 1.9e-117 393.1 8.7 2.5e-117 392.7 8.7 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 ORX71491.1 - 7.3e-06 24.7 8.0 7.3e-06 24.7 8.0 2.6 3 0 0 3 3 3 1 Exocyst complex component Sec3 COG6 PF06419.11 ORX71491.1 - 1.1e-05 23.9 5.7 0.0027 16.0 0.0 2.2 2 0 0 2 2 2 2 Conserved oligomeric complex COG6 Cu-oxidase_4 PF02578.15 ORX71491.1 - 0.16 11.5 0.0 0.36 10.4 0.0 1.5 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase DUF1664 PF07889.12 ORX71491.1 - 0.28 11.2 3.3 0.93 9.5 3.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ORX71491.1 - 0.65 8.8 9.2 1.7 7.5 9.2 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein Med4 PF10018.9 ORX71491.1 - 1.7 8.3 8.6 0.64 9.7 4.2 2.4 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Adaptin_N PF01602.20 ORX71492.1 - 1.8e-116 389.8 4.9 2.1e-116 389.6 4.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX71492.1 - 2.4e-59 200.0 4.4 8.3e-59 198.2 1.3 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 ORX71492.1 - 1.4e-18 67.0 0.0 4.8e-18 65.3 0.0 2.0 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 ORX71492.1 - 6.6e-18 64.9 5.7 3.6e-10 40.1 0.1 5.2 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 ORX71492.1 - 6.1e-12 44.7 0.9 0.032 14.5 0.1 6.2 5 0 0 5 5 5 3 HEAT repeat Arm PF00514.23 ORX71492.1 - 1.5e-07 31.2 0.8 0.39 10.8 0.0 5.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Alpha_adaptinC2 PF02883.20 ORX71492.1 - 1.8e-06 28.2 0.2 1.8e-06 28.2 0.2 2.4 3 0 0 3 3 2 1 Adaptin C-terminal domain Cnd3 PF12719.7 ORX71492.1 - 0.0001 21.6 0.0 0.11 11.6 0.0 2.4 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 ORX71492.1 - 0.00022 21.4 1.1 0.44 10.7 0.0 4.1 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ORX71492.1 - 0.00067 20.1 0.5 18 6.0 0.0 6.1 6 0 0 6 6 6 0 HEAT-like repeat IFRD PF05004.13 ORX71492.1 - 0.0008 18.6 0.0 0.093 11.8 0.0 2.5 2 0 0 2 2 2 1 Interferon-related developmental regulator (IFRD) U3snoRNP10 PF12397.8 ORX71492.1 - 0.087 13.2 0.0 0.44 10.9 0.0 2.2 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 10 Vac14_Fab1_bd PF12755.7 ORX71492.1 - 0.089 13.4 1.0 0.23 12.1 0.1 2.2 2 0 0 2 2 1 0 Vacuolar 14 Fab1-binding region FadR_C PF07840.12 ORX71492.1 - 0.14 12.0 1.2 13 5.6 0.1 2.5 2 0 0 2 2 2 0 FadR C-terminal domain DUF5578 PF17741.1 ORX71492.1 - 0.43 9.9 4.2 0.5 9.8 0.5 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5578) PAP_assoc PF03828.19 ORX71493.1 - 1e-16 60.9 0.1 2.2e-16 59.8 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX71493.1 - 5.4e-06 26.6 0.0 1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ORX71493.1 - 0.014 15.5 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase tRNA-synt_1 PF00133.22 ORX71494.1 - 1.7e-171 571.5 0.0 2.2e-171 571.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX71494.1 - 2.5e-25 89.2 0.1 4.2e-25 88.5 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX71494.1 - 5.4e-19 68.2 0.0 8.3e-14 51.1 0.0 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ORX71494.1 - 0.00065 19.3 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ORX71494.1 - 0.11 11.8 0.0 11 5.3 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain RecR PF02132.15 ORX71494.1 - 1.3 8.6 4.1 3.2 7.4 4.1 1.6 1 0 0 1 1 1 0 RecR protein baeRF_family5 PF18846.1 ORX71498.1 - 0.036 14.3 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 Calreticulin PF00262.18 ORX71501.1 - 2.7e-71 240.4 15.0 4.6e-52 177.1 3.9 2.8 2 1 1 3 3 3 2 Calreticulin family Borrelia_P83 PF05262.11 ORX71501.1 - 0.61 8.5 39.2 0.92 7.9 39.2 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Ribosomal_S21e PF01249.18 ORX71502.1 - 2.9e-39 133.0 0.0 3.3e-39 132.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e RNA_pol_Rpb6 PF01192.22 ORX71503.1 - 3.3e-17 62.1 0.1 4.3e-17 61.8 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 Med10 PF09748.9 ORX71504.1 - 1e-30 106.2 0.9 1.4e-30 105.8 0.9 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF677 PF05055.12 ORX71504.1 - 0.0037 16.2 0.9 0.004 16.1 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF677) Tweety PF04906.13 ORX71504.1 - 0.05 12.3 0.9 0.048 12.3 0.9 1.2 1 0 0 1 1 1 0 Tweety V-SNARE PF05008.15 ORX71504.1 - 0.05 14.0 3.8 0.054 13.9 2.2 1.8 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus MetOD2 PF18548.1 ORX71504.1 - 0.059 13.5 2.8 0.14 12.3 0.3 2.4 2 1 0 2 2 2 0 Metanogen output domain 2 Chlamy_scaf PF09675.10 ORX71504.1 - 0.067 13.5 0.2 0.13 12.6 0.2 1.5 1 1 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) DUF4795 PF16043.5 ORX71504.1 - 0.14 11.7 4.3 0.2 11.2 4.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) KIP1 PF07765.12 ORX71504.1 - 0.4 10.8 2.3 0.92 9.7 1.1 2.2 1 1 1 2 2 2 0 KIP1-like protein PAT1 PF09770.9 ORX71506.1 - 4e-87 293.4 1.2 6.6e-87 292.7 1.2 1.3 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 CNH PF00780.22 ORX71507.1 - 1.7e-40 139.3 0.0 2.6e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX71507.1 - 4.4e-28 98.8 0.0 6.7e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 ORX71507.1 - 6.4e-08 32.6 0.0 2.1e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_5 PF15405.6 ORX71507.1 - 0.015 15.4 0.0 0.29 11.2 0.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain PX PF00787.24 ORX71508.1 - 9.3e-23 80.4 0.4 9.3e-23 80.4 0.4 2.3 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 ORX71508.1 - 6.5e-10 39.0 9.9 9.2e-09 35.2 9.9 2.1 1 1 0 1 1 1 1 Vps5 C terminal like SpecificRecomb PF10136.9 ORX71508.1 - 0.028 12.8 8.1 0.0061 14.9 3.8 1.8 1 1 0 2 2 2 0 Site-specific recombinase DUF4988 PF16378.5 ORX71508.1 - 0.12 12.0 0.2 0.45 10.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function LUC7 PF03194.15 ORX71508.1 - 0.3 10.7 6.0 3.2 7.3 1.6 2.2 1 1 1 2 2 2 0 LUC7 N_terminus Fib_alpha PF08702.10 ORX71508.1 - 3.3 7.9 6.5 3.4 7.8 1.7 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.6 ORX71508.1 - 6.8 7.2 7.1 37 4.8 0.2 3.5 2 2 1 3 3 3 0 Snapin/Pallidin PCRF PF03462.18 ORX71509.1 - 1.3e-56 191.5 1.4 1.4e-56 191.5 0.1 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 ORX71509.1 - 3.4e-38 130.1 6.1 3.4e-38 130.1 6.1 1.9 2 0 0 2 2 2 1 RF-1 domain Ribosomal_S16 PF00886.19 ORX71511.1 - 4.1e-26 90.8 0.1 5.3e-26 90.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 SHS2_Rpb7-N PF03876.17 ORX71512.1 - 1.3e-16 60.8 0.0 2.1e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ORX71512.1 - 4.2e-12 46.2 0.1 6.4e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 ORX71512.1 - 0.022 15.0 0.1 0.03 14.6 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 HapK PF11639.8 ORX71514.1 - 0.065 13.7 0.2 0.37 11.3 0.1 2.3 2 0 0 2 2 2 0 REDY-like protein HapK UPF0160 PF03690.13 ORX71515.1 - 8.8e-139 462.5 0.0 1e-138 462.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Hydrolase_6 PF13344.6 ORX71516.1 - 2.2e-18 66.2 0.0 3.7e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX71516.1 - 2.7e-13 49.8 0.1 5.5e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX71516.1 - 3.5e-07 30.7 1.2 0.0013 19.1 0.1 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX71516.1 - 0.00047 20.3 0.0 0.084 13.0 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PLDc_2 PF13091.6 ORX71516.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 PLD-like domain Acid_phosphat_B PF03767.14 ORX71516.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LRR_9 PF14580.6 ORX71517.1 - 0.036 13.6 0.1 0.14 11.6 0.1 2.2 1 1 1 2 2 2 0 Leucine-rich repeat Glutaredoxin PF00462.24 ORX71518.1 - 7.7e-22 77.3 0.0 1e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ORX71518.1 - 0.0011 19.3 0.0 0.0012 19.2 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71518.1 - 0.002 18.4 0.0 0.0025 18.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 ORX71518.1 - 0.002 18.5 0.0 0.0026 18.1 0.0 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 ORX71518.1 - 0.0056 17.1 0.1 0.0093 16.4 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 ORX71518.1 - 0.028 14.2 0.1 0.059 13.1 0.1 1.6 1 1 0 1 1 1 0 DSBA-like thioredoxin domain TraF PF13728.6 ORX71518.1 - 0.041 13.7 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 ORX71518.1 - 0.078 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain DUF775 PF05603.12 ORX71519.1 - 1.3e-55 188.1 0.0 1.5e-55 187.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) LPD22 PF18834.1 ORX71519.1 - 0.014 15.6 0.5 0.022 14.9 0.5 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 B12D PF06522.11 ORX71521.1 - 6.3e-17 61.1 0.1 7.4e-17 60.9 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit HNH PF01844.23 ORX71522.1 - 0.0018 18.4 0.1 0.004 17.3 0.1 1.6 1 1 0 1 1 1 1 HNH endonuclease DUF968 PF06147.11 ORX71522.1 - 0.0039 17.5 0.0 0.006 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF968) HNH_2 PF13391.6 ORX71522.1 - 0.049 13.8 0.1 0.11 12.6 0.1 1.6 1 1 0 1 1 1 0 HNH endonuclease ADD_DNMT3 PF17980.1 ORX71522.1 - 0.28 11.2 1.5 2.6 8.1 0.1 2.3 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 CNH PF00780.22 ORX71523.1 - 1.6e-48 165.7 0.0 3.5e-48 164.6 0.0 1.5 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX71523.1 - 8.8e-29 101.0 0.7 2.4e-28 99.6 0.7 1.7 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX71523.1 - 1.4e-26 93.2 2.4 5e-26 91.4 0.1 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 ORX71523.1 - 6.4e-05 22.8 0.0 0.21 11.4 0.0 2.9 2 0 0 2 2 2 2 Pleckstrin homology domain DEP PF00610.21 ORX71523.1 - 0.00013 21.9 0.0 0.0003 20.8 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 ORX71523.1 - 0.01 16.3 0.0 1.4 9.4 0.0 2.6 2 0 0 2 2 2 0 PH domain DUF3246 PF11596.8 ORX71523.1 - 0.12 11.8 0.6 0.26 10.7 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Sld5 PF05916.11 ORX71524.1 - 0.047 14.1 0.0 0.07 13.6 0.0 1.3 1 0 0 1 1 1 0 GINS complex protein Mg_trans_NIPA PF05653.14 ORX71527.1 - 1.7e-102 342.5 19.8 2e-102 342.3 19.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX71527.1 - 5.2e-05 23.4 6.3 5.2e-05 23.4 6.3 3.8 3 1 0 3 3 3 2 EamA-like transporter family DUF2937 PF11157.8 ORX71527.1 - 0.15 11.8 1.7 0.99 9.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) COX7C PF02935.16 ORX71528.1 - 0.00036 20.7 7.8 0.0072 16.6 7.8 2.0 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Bot1p PF12298.8 ORX71529.1 - 4.5e-12 46.5 0.1 1.5e-06 28.5 0.3 2.1 1 1 1 2 2 2 2 Eukaryotic mitochondrial regulator protein Glyco_hydro_18 PF00704.28 ORX71530.1 - 8.5e-55 186.7 1.5 1.5e-54 185.8 1.5 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX71530.1 - 1.8e-05 24.7 15.2 1.8e-05 24.7 15.2 2.5 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) Pardaxin PF07425.11 ORX71530.1 - 0.31 10.7 3.1 0.69 9.6 0.3 2.5 2 0 0 2 2 2 0 Pardaxin MSA-2c PF12238.8 ORX71530.1 - 5.7 6.9 6.9 12 5.8 6.9 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Glyco_hydro_18 PF00704.28 ORX71531.1 - 7.6e-75 252.5 4.2 9.4e-75 252.2 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX71531.1 - 2.7e-05 24.1 15.6 2.7e-05 24.1 15.6 2.7 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX71531.1 - 0.76 10.0 4.8 1.6 9.0 4.8 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain MSA-2c PF12238.8 ORX71531.1 - 8.1 6.4 6.9 17 5.3 6.9 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Glyco_hydro_18 PF00704.28 ORX71532.1 - 7.9e-74 249.2 3.1 9.7e-74 248.9 3.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX71532.1 - 1.2e-05 25.1 14.9 1.2e-05 25.1 14.9 2.4 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX71532.1 - 0.3 11.3 5.3 0.63 10.2 5.3 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain RNR_Alpha PF17975.1 ORX71533.1 - 0.06 13.8 0.0 0.077 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain Pkinase PF00069.25 ORX71534.1 - 2.5e-70 236.8 0.0 2.9e-70 236.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71534.1 - 4.3e-46 157.3 0.0 5.1e-46 157.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71534.1 - 3.7e-05 23.2 0.0 0.0051 16.2 0.1 2.5 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 ORX71534.1 - 0.051 13.5 0.0 1.1 9.1 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX71534.1 - 0.069 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ORX71534.1 - 0.085 11.9 0.0 0.16 11.0 0.0 1.4 1 1 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 ORX71534.1 - 0.11 11.3 0.0 0.25 10.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Acyl-CoA_dh_N PF02771.16 ORX71535.1 - 4.9e-21 75.5 0.0 1.2e-20 74.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 ORX71535.1 - 7.3e-18 65.2 1.8 6.8e-12 45.8 0.4 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX71535.1 - 3.9e-14 52.6 0.0 1.7e-13 50.6 0.0 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX71535.1 - 1.1e-06 29.0 1.8 3.5e-05 24.1 2.2 2.4 1 1 1 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain XdhC_CoxI PF02625.16 ORX71535.1 - 0.083 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 XdhC and CoxI family GRAB PF10375.9 ORX71536.1 - 0.0024 17.7 0.7 0.0054 16.6 0.7 1.5 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Lambda_tail_I PF06805.12 ORX71536.1 - 0.025 14.9 3.8 8.6 6.8 0.2 3.8 3 1 1 4 4 4 0 Bacteriophage lambda tail assembly protein I AAA_18 PF13238.6 ORX71536.1 - 0.081 13.5 13.9 0.056 14.0 5.5 3.4 2 2 0 2 2 2 0 AAA domain BORCS7 PF16088.5 ORX71536.1 - 2.4 8.5 9.6 15 5.9 6.7 3.0 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 Allexi_40kDa PF05549.11 ORX71536.1 - 7.2 6.0 15.1 0.2 11.2 5.2 2.9 2 1 2 4 4 4 0 Allexivirus 40kDa protein Trypsin PF00089.26 ORX71537.1 - 2e-21 76.8 0.0 2.3e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX71537.1 - 0.0095 16.8 0.0 0.02 15.8 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ORX71538.1 - 3.7e-05 23.6 0.0 4.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 ORX71539.1 - 1.3e-13 51.3 0.0 1.5e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX71539.1 - 0.072 14.0 0.0 0.091 13.6 0.0 1.2 1 0 0 1 1 1 0 Trypsin-like peptidase domain 2OG-FeII_Oxy_3 PF13640.6 ORX71542.1 - 0.0024 18.7 0.0 0.0044 17.9 0.0 1.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Cwf_Cwc_15 PF04889.12 ORX71543.1 - 0.17 11.6 8.5 0.54 9.9 8.5 1.8 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 ORX71543.1 - 0.31 11.1 2.4 1.3 9.0 2.4 2.1 1 0 0 1 1 1 0 RXT2-like, N-terminal TFIIA PF03153.13 ORX71543.1 - 0.45 10.5 6.2 0.23 11.4 3.5 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SNAPc19 PF15497.6 ORX71544.1 - 0.0011 19.3 0.2 0.0011 19.3 0.2 3.3 3 1 0 3 3 3 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 YIF1 PF03878.15 ORX71545.1 - 2.5e-65 220.3 5.8 8.5e-64 215.3 0.3 2.2 1 1 1 2 2 2 2 YIF1 Yip1 PF04893.17 ORX71545.1 - 0.001 18.9 0.8 0.0018 18.0 0.1 1.7 2 0 0 2 2 2 1 Yip1 domain Hus1 PF04005.12 ORX71546.1 - 6.5e-51 173.2 0.1 5.4e-30 104.5 0.3 2.5 1 1 1 2 2 2 2 Hus1-like protein DUF5401 PF17380.2 ORX71546.1 - 0.14 10.3 0.0 0.17 9.9 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) BAT PF15915.5 ORX71546.1 - 0.17 11.7 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 GAF and HTH_10 associated domain Trypsin PF00089.26 ORX71547.1 - 8.5e-26 91.1 1.7 3.1e-25 89.3 1.7 1.7 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX71547.1 - 0.0026 18.7 0.5 0.0098 16.8 0.5 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ORX71548.1 - 1.6e-15 57.6 1.6 2.4e-14 53.7 1.6 2.0 1 1 0 1 1 1 1 Trypsin Peptidase_M24 PF00557.24 ORX71550.1 - 1.2e-45 155.8 0.0 1.9e-45 155.2 0.0 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 PPR_long PF17177.4 ORX71551.1 - 0.093 12.1 0.3 0.26 10.6 0.3 1.7 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Pkinase_fungal PF17667.1 ORX71552.1 - 6.3e-18 64.7 0.0 6e-08 31.9 0.0 2.1 1 1 1 2 2 2 2 Fungal protein kinase WD40 PF00400.32 ORX71553.1 - 7.1e-12 45.7 9.0 3.3e-05 24.5 0.0 5.2 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX71553.1 - 0.0094 16.2 0.0 0.41 11.0 0.0 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PCI PF01399.27 ORX71554.1 - 7.9e-09 36.0 0.0 7.9e-09 36.0 0.0 3.2 4 1 0 4 4 4 1 PCI domain Trypsin PF00089.26 ORX71555.1 - 3.4e-28 99.0 0.1 6.2e-28 98.1 0.1 1.4 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX71555.1 - 4.3e-05 24.5 0.1 0.00018 22.4 0.1 1.9 1 1 1 2 2 2 1 Trypsin-like peptidase domain CALCOCO1 PF07888.11 ORX71556.1 - 0.077 11.9 27.1 0.14 11.0 27.1 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ERM PF00769.19 ORX71556.1 - 0.14 11.9 29.8 0.29 10.9 29.8 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF2721 PF11026.8 ORX71556.1 - 0.29 11.0 1.6 21 5.0 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) MscS_porin PF12795.7 ORX71556.1 - 0.42 10.1 29.2 0.86 9.1 16.6 2.7 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain HIP1_clath_bdg PF16515.5 ORX71556.1 - 1.5 9.5 31.4 0.12 13.0 12.2 4.0 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3584 PF12128.8 ORX71556.1 - 1.7 6.1 28.6 2.7 5.4 28.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.11 ORX71556.1 - 2.3 8.4 34.4 2.4 8.4 23.6 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Filament PF00038.21 ORX71556.1 - 2.5 7.6 29.3 1.9 8.0 5.7 3.1 1 1 0 2 2 2 0 Intermediate filament protein Spc7 PF08317.11 ORX71556.1 - 3.4 6.5 30.6 0.45 9.3 15.2 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 ORX71556.1 - 3.6 6.9 32.2 1.7 8.0 12.8 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF848 PF05852.11 ORX71556.1 - 5.7 7.1 16.4 0.44 10.7 2.4 2.8 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Fez1 PF06818.15 ORX71556.1 - 6.9 7.1 35.2 0.19 12.2 12.5 3.0 2 1 1 3 3 3 0 Fez1 Cob_adeno_trans PF01923.18 ORX71556.1 - 8.1 6.6 12.8 3.3 7.8 4.5 2.8 2 1 1 3 3 3 0 Cobalamin adenosyltransferase DUF4407 PF14362.6 ORX71556.1 - 8.4 5.6 23.7 6.1 6.1 12.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) RIBIOP_C PF04950.12 ORX71557.1 - 9.6e-71 238.6 0.4 9.6e-71 238.6 0.4 2.0 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ORX71557.1 - 2.3e-28 98.1 0.0 8.2e-28 96.3 0.0 2.1 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 ORX71557.1 - 1.7e-06 27.7 1.3 0.0012 18.4 0.0 3.6 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ORX71557.1 - 6.1e-05 22.8 0.1 0.00022 21.0 0.1 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ORX71557.1 - 0.00014 22.1 0.0 0.00043 20.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX71557.1 - 0.00026 21.4 0.0 0.00084 19.8 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX71557.1 - 0.00061 20.2 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX71557.1 - 0.0013 18.8 0.0 0.02 15.0 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 ORX71557.1 - 0.0022 18.0 0.1 0.027 14.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 ORX71557.1 - 0.0088 16.4 0.1 0.047 14.1 0.0 2.4 2 0 0 2 2 1 1 RNA helicase AAA_33 PF13671.6 ORX71557.1 - 0.026 14.7 0.9 0.086 13.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ORX71557.1 - 0.028 14.4 0.1 0.13 12.1 0.1 2.2 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 ORX71557.1 - 0.037 14.6 1.3 0.4 11.2 0.0 3.2 3 1 0 3 3 2 0 AAA domain ABC_tran PF00005.27 ORX71557.1 - 0.081 13.4 2.9 0.12 12.8 0.0 2.8 4 0 0 4 4 2 0 ABC transporter AAA_28 PF13521.6 ORX71557.1 - 0.089 13.0 1.5 0.19 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 ORX71557.1 - 0.096 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B ATPase_2 PF01637.18 ORX71557.1 - 0.15 11.9 0.0 0.15 11.9 0.0 2.6 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea RabGAP-TBC PF00566.18 ORX71558.1 - 4.4e-46 157.2 0.8 1.3e-45 155.7 0.1 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 ORX71558.1 - 2.5e-22 78.9 0.1 9e-13 48.1 0.1 3.3 3 0 0 3 3 3 2 GRAM domain Mito_carr PF00153.27 ORX71559.1 - 2.4e-59 197.3 6.6 4.4e-20 71.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX71559.1 - 0.0027 16.9 1.0 0.0058 15.8 0.2 1.9 2 0 0 2 2 2 1 Gammaproteobacterial serine protease GST_C_3 PF14497.6 ORX71560.1 - 7.5e-12 45.3 0.2 1.3e-11 44.5 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX71560.1 - 2.3e-05 24.7 0.1 7.8e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71560.1 - 2.5e-05 24.4 0.0 5.6e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71560.1 - 0.00084 19.7 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX71560.1 - 0.00089 19.2 0.1 0.0035 17.3 0.0 2.2 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain DUF1877 PF08974.10 ORX71560.1 - 0.08 13.0 0.0 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) GST_C_3 PF14497.6 ORX71561.1 - 1.7e-08 34.5 0.0 2.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX71561.1 - 7.8e-05 23.0 0.0 0.0012 19.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX71561.1 - 9.6e-05 22.7 0.1 0.00071 19.9 0.0 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX71561.1 - 0.005 17.1 0.1 0.02 15.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX71561.1 - 0.016 15.4 0.0 0.029 14.6 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX71561.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Histidinol_dh PF00815.20 ORX71563.1 - 1.1e-159 531.9 4.9 1.4e-159 531.5 4.9 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 ORX71563.1 - 7.8e-26 89.7 0.6 1.4e-25 88.9 0.6 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 ORX71563.1 - 1.3e-12 48.0 0.1 2.8e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF2408 PF10303.9 ORX71564.1 - 8.5e-54 181.8 5.0 2.4e-27 96.2 0.0 5.3 2 2 3 5 5 5 4 Protein of unknown function (DUF2408) N1221 PF07923.13 ORX71564.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 N1221-like protein MscS_porin PF12795.7 ORX71564.1 - 0.031 13.8 6.0 1.2 8.7 2.5 2.8 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain ABC_tran_CTD PF16326.5 ORX71564.1 - 0.078 13.2 0.8 6.5 7.1 0.2 3.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF3546 PF12066.8 ORX71565.1 - 6.3e-16 58.5 5.6 1.5e-15 57.3 5.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 ORX71565.1 - 1.4e-11 45.2 12.5 1.3e-10 42.0 12.5 2.2 1 1 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 ORX71565.1 - 7.5e-08 32.0 3.2 7.5e-08 32.0 3.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) RRM_1 PF00076.22 ORX71565.1 - 2.4e-06 27.3 0.0 4.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_2 PF12756.7 ORX71565.1 - 0.0097 16.2 0.5 0.6 10.5 0.1 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX71565.1 - 2.8 8.3 7.9 0.7 10.3 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding ACOX PF01756.19 ORX71566.1 - 9.7e-42 142.6 0.0 5.1e-41 140.2 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX71566.1 - 1.8e-22 80.2 0.4 3.2e-22 79.4 0.4 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX71566.1 - 3.8e-11 43.0 0.0 8.6e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ORX71566.1 - 0.012 15.8 7.2 0.042 14.1 0.1 3.8 3 2 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain IFT46_B_C PF12317.8 ORX71566.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal RTA1 PF04479.13 ORX71567.1 - 5.9e-39 133.8 9.4 9.3e-39 133.2 9.4 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF962 PF06127.11 ORX71567.1 - 0.096 12.8 0.4 1.3 9.1 0.4 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF962) Abhydrolase_9_N PF15420.6 ORX71567.1 - 1.2 9.1 8.1 0.19 11.7 4.0 1.7 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus YrhC PF14143.6 ORX71567.1 - 3.5 7.8 6.5 0.9 9.7 0.3 2.8 3 0 0 3 3 3 0 YrhC-like protein F-box-like PF12937.7 ORX71569.1 - 0.08 12.9 1.9 0.16 11.9 0.5 2.3 2 0 0 2 2 2 0 F-box-like PX PF00787.24 ORX71570.1 - 7e-15 55.0 0.0 1.9e-14 53.6 0.0 1.7 2 0 0 2 2 2 1 PX domain Fe-S_assembly PF04384.13 ORX71570.1 - 0.047 14.3 2.7 0.76 10.4 0.1 2.5 2 0 0 2 2 2 0 Iron-sulphur cluster assembly DUF572 PF04502.13 ORX71571.1 - 2.2e-77 260.9 13.5 2.4e-77 260.8 13.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DNA_RNApol_7kD PF03604.13 ORX71571.1 - 0.05 13.3 1.5 4.8 6.9 0.5 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit RNA_pol_N PF01194.17 ORX71571.1 - 0.85 10.0 5.2 1.4 9.3 0.7 2.7 2 2 0 2 2 2 0 RNA polymerases N / 8 kDa subunit Sec63 PF02889.16 ORX71572.1 - 2.9e-133 442.8 0.0 2.7e-78 262.7 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ORX71572.1 - 4.5e-50 169.8 0.0 7.2e-26 91.0 0.1 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 ORX71572.1 - 1.6e-22 80.3 0.0 5.4e-10 39.5 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX71572.1 - 3.1e-17 62.9 0.0 3.4e-08 33.8 0.0 3.4 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ORX71572.1 - 1.4e-05 25.4 0.2 0.54 10.5 0.0 4.0 2 2 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX71572.1 - 0.006 15.7 0.0 3.2 6.7 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein Helicase_PWI PF18149.1 ORX71572.1 - 0.02 15.1 1.1 0.086 13.0 0.0 2.6 2 0 0 2 2 2 0 N-terminal helicase PWI domain AAA_11 PF13086.6 ORX71572.1 - 0.76 9.5 2.5 18 5.0 0.0 3.9 4 1 1 5 5 5 0 AAA domain PP2C PF00481.21 ORX71573.1 - 1.9e-77 260.4 0.0 2.7e-77 259.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Asparaginase_2 PF01112.18 ORX71573.1 - 0.014 14.4 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Asparaginase DUF3246 PF11596.8 ORX71574.1 - 0.056 12.9 1.8 0.19 11.2 1.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Nucleo_P87 PF07267.11 ORX71574.1 - 2.1 7.1 4.2 4.7 6.0 4.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 zf-CCCH_3 PF15663.5 ORX71575.1 - 0.00023 21.3 8.0 0.00091 19.4 2.5 2.2 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 ORX71575.1 - 0.056 13.3 16.9 0.12 12.2 1.9 3.9 3 1 0 3 3 3 0 CCCH-type zinc finger Transket_pyr PF02779.24 ORX71576.1 - 5.1e-53 179.4 0.0 1e-52 178.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 ORX71576.1 - 2.3e-44 150.8 0.0 3.6e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 ORX71576.1 - 7e-39 133.6 0.0 1.4e-37 129.3 0.0 2.3 2 0 0 2 2 2 1 Dehydrogenase E1 component Transket_pyr PF02779.24 ORX71577.1 - 2.1e-50 170.9 0.0 3.6e-50 170.1 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ORX71577.1 - 2.6e-45 154.7 0.0 4.2e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ORX71577.1 - 6.7e-20 71.3 0.0 6.4e-11 42.2 0.0 2.7 2 0 0 2 2 2 2 2-oxoglutarate dehydrogenase C-terminal Dynactin_p22 PF07426.11 ORX71578.1 - 5.2e-20 72.0 0.1 7.8e-20 71.4 0.1 1.3 1 0 0 1 1 1 1 Dynactin subunit p22 DUF2277 PF10041.9 ORX71578.1 - 0.056 13.8 1.5 0.056 13.8 1.5 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) Ribosomal_60s PF00428.19 ORX71579.1 - 2.4e-25 88.9 13.2 3.1e-25 88.6 13.2 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cas_Csn2 PF09711.10 ORX71579.1 - 0.093 12.4 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) 4HBT PF03061.22 ORX71580.1 - 8.6e-16 58.1 0.0 2.4e-15 56.7 0.0 1.7 1 1 1 2 2 2 1 Thioesterase superfamily 4HBT_3 PF13622.6 ORX71580.1 - 8.7e-05 22.9 0.0 0.0001 22.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.25 ORX71581.1 - 5.4e-70 235.8 0.0 6.7e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71581.1 - 5.8e-35 120.8 0.0 7.4e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71581.1 - 8.8e-07 28.5 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX71581.1 - 0.0018 17.2 0.0 0.0028 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase ATP_bind_1 PF03029.17 ORX71582.1 - 1.2e-75 254.4 0.1 1.5e-75 254.1 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 ORX71582.1 - 1.1e-05 25.4 0.0 0.0037 17.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX71582.1 - 0.00051 19.8 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX71582.1 - 0.0008 19.7 0.0 0.0018 18.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX71582.1 - 0.0021 18.6 0.1 0.0049 17.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ORX71582.1 - 0.0024 17.9 0.0 0.0037 17.3 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 ORX71582.1 - 0.0046 16.4 0.0 0.54 9.6 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family KTI12 PF08433.10 ORX71582.1 - 0.0055 16.2 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ORX71582.1 - 0.0069 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ORX71582.1 - 0.0073 16.0 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MeaB PF03308.16 ORX71582.1 - 0.0095 14.9 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 ORX71582.1 - 0.014 15.2 0.0 0.056 13.2 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_5 PF07728.14 ORX71582.1 - 0.016 15.2 0.0 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ORX71582.1 - 0.017 15.6 0.0 0.14 12.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ORX71582.1 - 0.02 15.3 0.1 0.044 14.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.15 ORX71582.1 - 0.027 13.6 0.0 0.063 12.4 0.0 1.5 2 0 0 2 2 2 0 Anion-transporting ATPase AAA_24 PF13479.6 ORX71582.1 - 0.03 14.0 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX71582.1 - 0.03 14.7 0.0 0.23 11.9 0.0 2.1 2 0 0 2 2 2 0 RNA helicase T2SSE PF00437.20 ORX71582.1 - 0.034 13.2 0.0 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 ORX71582.1 - 0.042 14.2 0.0 0.078 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ORX71582.1 - 0.043 13.3 0.0 0.57 9.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 ORX71582.1 - 0.043 13.4 0.3 0.23 11.0 0.3 2.0 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ORX71582.1 - 0.047 13.8 0.0 0.22 11.6 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Sigma54_activ_2 PF14532.6 ORX71582.1 - 0.056 13.6 0.0 0.48 10.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Thymidylate_kin PF02223.17 ORX71582.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase DUF2969 PF11184.8 ORX71582.1 - 0.085 13.3 0.0 0.26 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) NTPase_1 PF03266.15 ORX71582.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.7 1 1 0 1 1 1 0 NTPase DEAD_2 PF06733.15 ORX71583.1 - 5.1e-55 185.8 0.0 9.4e-55 184.9 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 ORX71583.1 - 2.9e-43 147.8 2.0 2.8e-39 134.8 0.7 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 ORX71583.1 - 8.5e-36 123.7 0.0 2.3e-35 122.3 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 ORX71583.1 - 0.0001 22.4 0.0 0.012 15.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ORX71583.1 - 0.037 12.7 0.0 3.9 6.1 0.0 2.3 2 0 0 2 2 2 0 SNF2 family N-terminal domain FH2 PF02181.23 ORX71583.1 - 0.11 11.7 0.2 0.19 10.8 0.2 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain LUC7 PF03194.15 ORX71584.1 - 2e-63 214.4 4.9 2.3e-63 214.2 4.9 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF4175 PF13779.6 ORX71584.1 - 0.004 15.1 2.3 0.0047 14.9 2.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) zf-U1 PF06220.12 ORX71584.1 - 0.045 13.5 1.6 1.4 8.7 0.0 2.6 2 0 0 2 2 2 0 U1 zinc finger KIP1 PF07765.12 ORX71584.1 - 0.056 13.6 1.7 1 9.5 0.2 2.5 1 1 1 2 2 2 0 KIP1-like protein PPR PF01535.20 ORX71584.1 - 0.31 11.4 1.6 0.51 10.7 0.1 2.2 2 1 0 2 2 2 0 PPR repeat CHCH PF06747.13 ORX71585.1 - 9e-10 38.4 5.5 1.4e-09 37.8 5.5 1.3 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 ORX71585.1 - 5.4e-05 23.3 2.2 7.9e-05 22.8 2.2 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 ORX71585.1 - 0.021 15.1 2.2 0.031 14.6 2.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 TAP_C PF03943.13 ORX71585.1 - 0.084 12.5 0.3 0.12 12.1 0.3 1.3 1 0 0 1 1 1 0 TAP C-terminal domain Get5_C PF18514.1 ORX71587.1 - 0.12 12.1 0.4 0.2 11.4 0.4 1.3 1 0 0 1 1 1 0 Get5 C-terminal domain Tcp11 PF05794.13 ORX71591.1 - 7e-29 101.2 0.0 8.3e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 T-complex protein 11 Cyclin_N PF00134.23 ORX71592.1 - 1.7e-12 47.2 0.5 2.2e-12 46.8 0.5 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Spy1 PF11357.8 ORX71592.1 - 0.012 15.9 1.3 0.02 15.2 1.0 1.8 1 1 0 1 1 1 0 Cell cycle regulatory protein TFIIB PF00382.19 ORX71592.1 - 0.05 13.7 0.0 0.1 12.7 0.0 1.6 1 1 0 1 1 1 0 Transcription factor TFIIB repeat NPR2 PF06218.11 ORX71593.1 - 7.7e-44 150.2 2.6 6.2e-28 97.7 2.3 3.6 1 1 1 3 3 3 3 Nitrogen permease regulator 2 TRPM_tetra PF16519.5 ORX71594.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Tetramerisation domain of TRPM SEN1_N PF12726.7 ORX71595.1 - 7.3e-11 41.0 0.0 9.2e-11 40.7 0.0 1.2 1 0 0 1 1 1 1 SEN1 N terminal SEN1_N PF12726.7 ORX71596.1 - 1.1e-06 27.2 0.0 1.4e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 SEN1 N terminal DUF2090 PF09863.9 ORX71597.1 - 0.23 10.5 0.0 0.31 10.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) AAA_11 PF13086.6 ORX71599.1 - 1.1e-40 140.1 0.3 2.2e-40 139.1 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ORX71599.1 - 1.4e-32 112.9 0.0 2.8e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX71599.1 - 1.8e-07 31.6 0.2 1.9e-05 25.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX71599.1 - 5.9e-07 29.4 0.5 1.2e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 ORX71599.1 - 0.002 17.7 0.3 0.0041 16.7 0.0 1.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Spc7 PF08317.11 ORX71599.1 - 0.0046 15.9 1.4 0.0071 15.3 1.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein AAA_22 PF13401.6 ORX71599.1 - 0.0097 16.2 0.0 0.12 12.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain CCDC85 PF10226.9 ORX71599.1 - 0.04 13.6 2.5 0.085 12.5 2.5 1.5 1 0 0 1 1 1 0 CCDC85 family DEAD PF00270.29 ORX71599.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA PF00004.29 ORX71599.1 - 0.13 12.7 0.1 0.44 11.0 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 ORX71599.1 - 0.18 11.8 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 ORX71599.1 - 1 9.8 2.4 3.6 8.0 2.4 1.8 1 1 0 1 1 1 0 AAA domain Prenyltrans PF00432.21 ORX71601.1 - 9.4e-38 127.6 1.8 3e-13 49.3 0.1 4.4 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat Pkinase PF00069.25 ORX71602.1 - 1.8e-33 116.1 4.9 3.7e-19 69.1 0.0 3.1 2 1 1 3 3 3 2 Protein kinase domain C1_1 PF00130.22 ORX71602.1 - 1.6e-13 50.3 31.4 6.4e-07 29.2 8.2 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 ORX71602.1 - 1.7e-12 47.2 0.4 7.9e-08 31.9 0.0 3.7 3 1 1 4 4 4 2 Protein tyrosine kinase HR1 PF02185.16 ORX71602.1 - 1.6e-08 34.5 15.6 2.6e-06 27.5 0.8 3.9 4 0 0 4 4 4 2 Hr1 repeat Pkinase_C PF00433.24 ORX71602.1 - 5.2e-07 30.3 2.4 1.5e-06 28.8 2.4 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.16 ORX71602.1 - 4.3 7.7 20.6 1.7 9.0 7.2 2.4 2 0 0 2 2 2 0 C1 domain Tim17 PF02466.19 ORX71603.1 - 2.7e-34 117.9 9.7 3.2e-34 117.7 9.7 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DAO PF01266.24 ORX71604.1 - 4.5e-54 184.4 1.1 5.1e-54 184.2 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 ORX71604.1 - 1.5e-28 99.2 0.8 3.7e-28 97.9 0.8 1.7 1 1 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ORX71604.1 - 1.1e-09 37.9 3.8 5.4e-09 35.6 3.8 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ORX71604.1 - 4.2e-06 26.4 0.5 0.00013 21.4 0.1 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX71604.1 - 0.00052 19.3 0.2 0.0013 18.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX71604.1 - 0.0014 18.0 0.2 0.013 14.8 0.2 2.3 2 1 0 2 2 2 1 FAD binding domain GIDA PF01134.22 ORX71604.1 - 0.0031 16.7 0.3 0.036 13.1 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A EF-hand_6 PF13405.6 ORX71604.1 - 0.017 15.0 0.1 0.08 12.9 0.1 2.2 1 0 0 1 1 1 0 EF-hand domain HI0933_like PF03486.14 ORX71604.1 - 0.021 13.6 0.5 0.037 12.7 0.5 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.6 ORX71604.1 - 0.022 15.0 0.2 0.094 13.0 0.3 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain EF-hand_7 PF13499.6 ORX71604.1 - 0.033 14.6 0.0 0.084 13.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 ORX71604.1 - 0.041 13.4 0.1 0.14 11.8 0.1 2.0 1 0 0 1 1 1 0 EF hand 3HCDH_N PF02737.18 ORX71604.1 - 0.16 11.9 0.3 0.28 11.0 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TPP_enzyme_N PF02776.18 ORX71606.1 - 5.6e-51 172.6 2.1 6.8e-48 162.5 0.5 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ORX71606.1 - 8.9e-37 125.9 0.0 2e-36 124.7 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ORX71606.1 - 1.6e-31 109.1 0.0 4.6e-31 107.7 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ORX71606.1 - 0.0026 17.0 0.1 0.0046 16.2 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PNTB PF02233.16 ORX71606.1 - 0.0029 16.6 0.8 0.012 14.6 0.2 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit B12-binding PF02310.19 ORX71606.1 - 0.0081 16.2 2.6 0.015 15.4 0.2 2.6 4 0 0 4 4 4 1 B12 binding domain START PF01852.19 ORX71607.1 - 7.6e-13 48.4 0.0 1.1e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 START domain DUF2391 PF09622.10 ORX71607.1 - 0.072 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) BAG PF02179.16 ORX71608.1 - 3.6e-11 43.3 1.0 3.6e-11 43.3 1.0 3.2 3 0 0 3 3 3 1 BAG domain DUF3245 PF11595.8 ORX71610.1 - 7.7e-08 32.9 8.9 1.1e-06 29.2 0.1 2.7 1 1 2 3 3 3 2 Protein of unknown function (DUF3245) RBB1NT PF08169.11 ORX71611.1 - 8.2e-08 32.3 0.0 1.5e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 RBB1NT (NUC162) domain PWWP PF00855.17 ORX71611.1 - 1.8e-07 31.4 0.0 3.3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 PWWP domain ABC_tran PF00005.27 ORX71612.1 - 2.3e-25 89.7 0.0 3e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX71612.1 - 6.2e-08 32.8 0.0 0.00056 19.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX71612.1 - 0.00014 22.3 0.1 0.00019 21.8 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX71612.1 - 0.00089 19.5 0.0 0.0022 18.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX71612.1 - 0.0016 18.4 0.0 0.0034 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 ORX71612.1 - 0.0023 17.9 0.0 0.0083 16.0 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 ORX71612.1 - 0.0026 17.5 0.0 0.0065 16.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX71612.1 - 0.006 16.5 0.0 0.0096 15.8 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ORX71612.1 - 0.011 15.8 0.1 0.02 15.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 ORX71612.1 - 0.014 14.9 0.0 0.059 12.8 0.0 1.8 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 ORX71612.1 - 0.017 14.8 0.1 0.045 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ORX71612.1 - 0.05 14.0 0.0 0.21 12.0 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ORX71612.1 - 0.055 14.0 0.0 0.083 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ORX71612.1 - 0.066 13.4 0.0 1.1 9.6 0.0 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 ORX71612.1 - 0.075 13.6 0.0 0.21 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ORX71612.1 - 0.11 11.9 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ORX71612.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Nefa_Nip30_N PF10187.9 ORX71613.1 - 7.2e-06 26.3 3.9 7.2e-06 26.3 3.9 1.9 1 1 1 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DFP PF04127.15 ORX71615.1 - 2.9e-10 40.3 0.0 0.00094 19.1 0.0 2.6 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Acyl-CoA_dh_1 PF00441.24 ORX71619.1 - 1.4e-42 145.4 0.0 2.7e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX71619.1 - 6.3e-39 133.1 0.1 1.1e-38 132.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ORX71619.1 - 2.8e-26 91.5 0.0 5.2e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX71619.1 - 1.4e-12 48.1 0.0 3.2e-12 46.9 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ORX71619.1 - 0.13 11.9 0.0 0.53 9.9 0.0 1.9 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal ResIII PF04851.15 ORX71620.1 - 8.1e-24 84.5 0.0 1.2e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX71620.1 - 3.6e-15 56.3 0.1 4.9e-13 49.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX71620.1 - 1.6e-13 50.8 0.0 3.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ORX71620.1 - 2e-05 24.4 0.0 2.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 ORX71620.1 - 0.00019 20.8 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 ORX71620.1 - 0.0015 18.3 0.0 0.4 10.4 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX71620.1 - 0.026 14.8 0.0 0.26 11.6 0.1 2.6 2 2 0 2 2 2 0 AAA domain DHHC PF01529.20 ORX71621.1 - 3.6e-35 121.0 8.2 3.6e-35 121.0 8.2 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase M20_dimer PF07687.14 ORX71622.1 - 5.2e-07 29.6 0.1 1.4e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX71622.1 - 9.5e-07 28.7 0.0 4.2e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 ABC1 PF03109.16 ORX71623.1 - 5e-26 91.2 0.1 1.1e-25 90.1 0.1 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 ORX71623.1 - 0.0055 16.6 0.0 0.31 10.9 0.0 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family OPT PF03169.15 ORX71624.1 - 4.3e-167 557.4 47.9 4.9e-167 557.3 47.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Tmemb_14 PF03647.13 ORX71624.1 - 0.67 10.7 6.1 4.1 8.2 0.5 4.2 4 0 0 4 4 4 0 Transmembrane proteins 14C Arrestin_N PF00339.29 ORX71625.1 - 6e-09 36.1 0.0 1.2e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX71625.1 - 7.2e-05 23.3 0.0 0.0034 17.8 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain FliJ PF02050.16 ORX71626.1 - 0.00016 21.9 7.9 0.009 16.2 1.6 2.1 1 1 1 2 2 2 2 Flagellar FliJ protein MoCF_biosynth PF00994.24 ORX71626.1 - 0.1 12.3 0.0 6.6 6.4 0.0 2.1 1 1 1 2 2 2 0 Probable molybdopterin binding domain DUF1018 PF06252.12 ORX71626.1 - 0.12 13.3 2.0 5.6 8.0 2.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) TGFb_propeptide PF00688.18 ORX71626.1 - 2 8.1 5.6 0.68 9.6 0.7 1.9 1 1 1 2 2 2 0 TGF-beta propeptide SAM_decarbox PF01536.16 ORX71629.1 - 3.4e-115 384.9 0.0 5.5e-115 384.2 0.0 1.3 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase Glutaredoxin PF00462.24 ORX71630.1 - 4.2e-06 26.9 0.0 1.1e-05 25.5 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin Sulfolobus_pRN PF05584.11 ORX71630.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Se-cys_synth_N PF12390.8 ORX71631.1 - 0.17 12.2 1.0 0.77 10.0 0.0 2.8 3 1 0 3 3 3 0 Selenocysteine synthase N terminal Mito_carr PF00153.27 ORX71632.1 - 6.5e-71 234.3 3.3 5.4e-25 87.1 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein TetR_C_17 PF17922.1 ORX71633.1 - 0.078 13.1 0.1 17 5.6 0.0 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain UCR_14kD PF02271.16 ORX71634.1 - 1.6e-33 114.6 0.3 2e-33 114.3 0.3 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit DndE PF08870.11 ORX71634.1 - 0.14 12.4 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 DNA sulphur modification protein DndE F-box-like PF12937.7 ORX71635.1 - 5.7e-11 42.1 0.8 1.3e-10 41.0 0.8 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ORX71635.1 - 2.9e-07 30.7 0.0 0.075 13.5 0.0 3.6 1 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX71635.1 - 1.7e-06 27.6 1.9 0.26 11.4 0.0 5.3 6 0 0 6 6 6 2 Leucine Rich repeat F-box PF00646.33 ORX71635.1 - 0.00012 21.9 0.9 0.00029 20.7 0.1 2.1 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.33 ORX71635.1 - 0.092 13.3 1.4 13 6.8 1.0 3.6 2 1 0 2 2 2 0 Leucine Rich Repeat FliJ PF02050.16 ORX71638.1 - 0.00016 21.9 7.9 0.009 16.2 1.6 2.1 1 1 1 2 2 2 2 Flagellar FliJ protein MoCF_biosynth PF00994.24 ORX71638.1 - 0.1 12.3 0.0 6.6 6.4 0.0 2.1 1 1 1 2 2 2 0 Probable molybdopterin binding domain DUF1018 PF06252.12 ORX71638.1 - 0.12 13.3 2.0 5.6 8.0 2.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) TGFb_propeptide PF00688.18 ORX71638.1 - 2 8.1 5.6 0.68 9.6 0.7 1.9 1 1 1 2 2 2 0 TGF-beta propeptide Arrestin_N PF00339.29 ORX71639.1 - 5.6e-09 36.2 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX71639.1 - 6.5e-05 23.4 0.0 0.0032 17.9 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain OPT PF03169.15 ORX71640.1 - 4.5e-166 554.1 46.1 5.1e-166 553.9 46.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Tmemb_14 PF03647.13 ORX71640.1 - 0.51 11.1 5.8 3.8 8.3 0.5 4.2 4 0 0 4 4 4 0 Transmembrane proteins 14C Formyl_trans_N PF00551.19 ORX71641.1 - 3.5e-25 88.8 0.0 7.8e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 ORX71641.1 - 3e-09 37.0 0.0 6.9e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain CAP_GLY PF01302.25 ORX71642.1 - 4.6e-26 90.6 3.1 5.2e-26 90.5 1.9 1.7 2 0 0 2 2 2 1 CAP-Gly domain Ubiquitin_2 PF14560.6 ORX71642.1 - 1.3e-21 76.8 0.1 4.6e-21 75.1 0.0 2.0 1 1 1 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 ORX71642.1 - 0.017 14.8 0.0 0.067 12.9 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin family ADH_zinc_N PF00107.26 ORX71643.1 - 3.6e-31 107.9 1.1 5.1e-31 107.4 1.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX71643.1 - 3.6e-18 66.9 0.0 5.7e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX71643.1 - 2.7e-10 40.1 0.0 4e-08 33.1 0.0 3.2 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain SIS_2 PF13580.6 ORX71643.1 - 0.0048 16.9 0.1 0.065 13.3 0.1 2.2 2 0 0 2 2 2 1 SIS domain HupF_HypC PF01455.18 ORX71643.1 - 0.028 14.6 0.7 0.26 11.5 0.1 2.6 3 0 0 3 3 3 0 HupF/HypC family MS_channel PF00924.18 ORX71645.1 - 5.5e-23 81.6 0.6 8.5e-23 81.0 0.6 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 ORX71645.1 - 0.00019 20.7 1.4 0.00055 19.3 1.4 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ORX71645.1 - 0.00035 19.9 1.3 0.0011 18.4 1.3 1.8 1 0 0 1 1 1 1 EF hand DUF1700 PF08006.11 ORX71645.1 - 0.00052 19.6 1.8 0.0011 18.6 2.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1700) EF-hand_6 PF13405.6 ORX71645.1 - 0.0021 17.8 3.4 0.0022 17.8 0.4 2.5 2 0 0 2 2 2 1 EF-hand domain NDUF_C2 PF06374.11 ORX71645.1 - 0.15 12.2 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) MttA_Hcf106 PF02416.16 ORX71645.1 - 0.21 11.0 1.1 0.4 10.1 1.1 1.4 1 0 0 1 1 1 0 mttA/Hcf106 family Phosphodiest PF01663.22 ORX71646.1 - 4.8e-78 263.3 1.0 6.1e-78 262.9 1.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ORX71646.1 - 0.0069 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PLN_propep PF16485.5 ORX71646.1 - 0.32 10.8 1.0 0.79 9.5 0.2 2.0 2 0 0 2 2 2 0 Protealysin propeptide Rab5-bind PF09311.11 ORX71647.1 - 0.054 12.9 2.9 0.082 12.3 2.9 1.2 1 0 0 1 1 1 0 Rabaptin-like protein EBA-175_VI PF11556.8 ORX71647.1 - 0.22 11.8 0.1 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 Erythrocyte binding antigen 175 LRR_4 PF12799.7 ORX71648.1 - 0.035 14.5 9.7 3.4 8.2 0.4 5.6 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) M20_dimer PF07687.14 ORX71649.1 - 3.4e-06 26.9 0.2 1.7e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX71649.1 - 8.3e-06 25.6 0.0 2.2e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ORX71650.1 - 1.7e-08 34.3 0.1 6.9e-08 32.4 0.1 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX71650.1 - 0.00012 21.9 0.0 0.00022 21.0 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 ATP-synt_ab PF00006.25 ORX71651.1 - 4.9e-68 229.0 0.0 7.2e-68 228.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX71651.1 - 7e-06 26.5 0.5 1.9e-05 25.1 0.5 1.8 1 1 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 ORX71651.1 - 0.04 14.1 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5535) Ribonuc_red_lgC PF02867.15 ORX71652.1 - 2.8e-147 491.4 0.0 9.9e-81 271.8 0.0 2.8 2 1 1 3 3 3 2 Ribonucleotide reductase, barrel domain ATP-cone PF03477.16 ORX71652.1 - 4.6e-12 46.4 0.1 1.5e-11 44.7 0.1 1.9 1 0 0 1 1 1 1 ATP cone domain Ly-6_related PF06579.12 ORX71652.1 - 0.091 13.0 0.1 0.27 11.5 0.1 1.7 2 0 0 2 2 2 0 Caenorhabditis elegans ly-6-related protein zf-C4H2 PF10146.9 ORX71653.1 - 0.34 11.2 6.9 0.5 10.6 6.8 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein RNA_pol_Rpb2_6 PF00562.28 ORX71655.1 - 2.4e-112 375.8 0.2 3.7e-112 375.2 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 ORX71655.1 - 2e-34 117.9 0.3 4.3e-34 116.8 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.15 ORX71655.1 - 1.1e-30 106.7 0.0 6.8e-30 104.1 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ORX71655.1 - 4e-20 71.8 0.0 8.1e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 ORX71655.1 - 3e-14 53.1 0.1 5.7e-12 45.7 0.0 2.9 1 1 1 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 ORX71655.1 - 1.8e-13 50.5 0.3 5.4e-13 49.0 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ORX71655.1 - 5.4e-12 46.1 1.9 1.6e-11 44.5 1.9 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RecR PF02132.15 ORX71655.1 - 0.18 11.4 0.2 0.42 10.2 0.2 1.6 1 0 0 1 1 1 0 RecR protein zn-ribbon_14 PF16503.5 ORX71655.1 - 0.53 9.8 2.0 1.5 8.4 2.0 1.8 1 0 0 1 1 1 0 Zinc-ribbon A2L_zn_ribbon PF08792.10 ORX71658.1 - 0.0042 16.8 0.2 0.009 15.7 0.2 1.6 1 0 0 1 1 1 1 A2L zinc ribbon domain TPR_11 PF13414.6 ORX71658.1 - 0.032 13.9 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 TPR repeat SPC25 PF06703.11 ORX71658.1 - 0.076 12.8 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) MMS1_N PF10433.9 ORX71661.1 - 1.8e-61 208.3 0.0 3e-61 207.6 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX71661.1 - 9.1e-47 159.9 0.0 3.3e-44 151.5 0.0 3.1 2 1 0 2 2 2 2 CPSF A subunit region Carboxyl_trans PF01039.22 ORX71663.1 - 5.9e-164 546.3 0.3 1.9e-163 544.6 0.3 1.7 1 1 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ORX71663.1 - 0.0096 15.4 0.5 0.22 11.0 0.0 2.6 2 1 1 3 3 3 1 Malonate decarboxylase gamma subunit (MdcE) Trypsin PF00089.26 ORX71664.1 - 4.6e-38 131.2 1.0 6.1e-38 130.8 1.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX71664.1 - 7.6e-08 33.4 0.0 1.3e-07 32.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 ORX71664.1 - 0.0034 17.8 0.0 0.58 10.5 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) NIF PF03031.18 ORX71665.1 - 4.9e-23 81.6 0.0 6.8e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 ORX71665.1 - 1.1e-08 34.7 0.0 2.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ORX71665.1 - 0.15 12.5 0.1 0.59 10.6 0.0 2.1 2 1 0 2 2 2 0 Ubiquitin-like domain Asn_synthase PF00733.21 ORX71666.1 - 3.1e-10 40.3 0.0 6.9e-10 39.1 0.0 1.7 1 1 0 1 1 1 1 Asparagine synthase QueC PF06508.13 ORX71666.1 - 0.17 11.3 0.3 0.54 9.7 0.0 2.0 2 1 0 2 2 2 0 Queuosine biosynthesis protein QueC LysM PF01476.20 ORX71667.1 - 4.3e-35 119.5 0.0 1.9e-13 50.2 0.0 4.2 4 0 0 4 4 4 4 LysM domain FhuF_C PF11575.8 ORX71667.1 - 0.15 12.0 0.6 5.9 6.9 0.1 2.8 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain Chorismate_bind PF00425.18 ORX71668.1 - 7.2e-53 179.8 0.0 2e-52 178.3 0.0 1.7 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 ORX71668.1 - 6.7e-17 61.9 0.0 4.6e-16 59.1 0.0 2.3 2 1 0 2 2 2 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 ORX71668.1 - 8.5e-09 35.8 0.0 1.9e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Trypsin PF00089.26 ORX71669.1 - 9.8e-10 38.6 0.3 2.1e-09 37.5 0.3 1.6 1 1 0 1 1 1 1 Trypsin CRAL_TRIO_2 PF13716.6 ORX71671.1 - 1.7e-33 115.7 0.2 3e-33 114.9 0.2 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 ORX71671.1 - 1.3e-30 106.2 0.0 2e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 ORX71671.1 - 0.00096 18.9 0.1 0.002 17.9 0.1 1.5 1 1 0 1 1 1 1 CRAL/TRIO domain Cullin PF00888.22 ORX71671.1 - 0.14 10.8 0.1 0.19 10.3 0.1 1.1 1 0 0 1 1 1 0 Cullin family SART-1 PF03343.13 ORX71672.1 - 1.4e-09 37.1 11.7 1.5e-07 30.4 0.4 2.0 1 1 1 2 2 2 2 SART-1 family MM_CoA_mutase PF01642.22 ORX71672.1 - 0.047 12.3 0.4 0.051 12.1 0.4 1.0 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase His_Phos_2 PF00328.22 ORX71764.1 - 0.12 11.6 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Transferase PF02458.15 ORX71765.1 - 1.3e-19 70.3 0.0 7.1e-19 67.8 0.0 1.9 1 1 0 1 1 1 1 Transferase family FCH PF00611.23 ORX71766.1 - 1.9e-07 31.2 3.0 2.7e-07 30.8 0.6 2.6 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 ORX71766.1 - 0.035 13.8 0.5 0.2 11.4 0.2 2.4 2 1 0 2 2 2 0 Variant SH3 domain OEP PF02321.18 ORX71766.1 - 0.035 13.9 3.4 0.061 13.1 1.0 2.3 1 1 0 2 2 2 0 Outer membrane efflux protein SH3_1 PF00018.28 ORX71766.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 SH3 domain LRR_4 PF12799.7 ORX71767.1 - 1.3e-22 79.5 18.8 3.7e-06 27.2 2.6 5.6 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX71767.1 - 1.7e-13 50.5 10.7 8.1e-07 28.7 6.4 2.8 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 ORX71767.1 - 7.5e-12 44.8 21.8 0.00047 19.9 1.6 5.3 1 1 5 6 6 6 6 Leucine rich repeat LRR_6 PF13516.6 ORX71767.1 - 3.5 7.9 13.1 68 3.9 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 ORX71767.1 - 4.2 8.3 13.7 19 6.3 0.1 6.3 7 2 0 7 7 7 0 Leucine Rich Repeat S4 PF01479.25 ORX71768.1 - 8.8e-14 51.0 0.0 1.7e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 ORX71768.1 - 2.4e-08 34.8 1.4 4.1e-08 34.0 1.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DUF2423 PF10338.9 ORX71769.1 - 1.8e-15 56.9 3.1 1.8e-15 56.9 3.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF2161 PF09929.9 ORX71769.1 - 0.064 13.4 4.6 0.098 12.8 4.6 1.4 1 1 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Folliculin PF11704.8 ORX71769.1 - 0.34 10.8 5.3 0.37 10.6 5.3 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Cullin PF00888.22 ORX71770.1 - 7.9e-79 265.9 0.0 3.9e-78 263.6 0.0 1.9 1 1 0 1 1 1 1 Cullin family DUF3533 PF12051.8 ORX71770.1 - 1e-22 80.6 0.1 2.6e-15 56.2 0.0 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF3533) Cullin_Nedd8 PF10557.9 ORX71770.1 - 2.2e-07 30.8 0.7 6.8e-07 29.2 0.7 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain ABC2_membrane_3 PF12698.7 ORX71770.1 - 0.022 13.9 0.1 10 5.1 0.5 3.0 2 1 1 3 3 3 0 ABC-2 family transporter protein p450 PF00067.22 ORX71771.1 - 1.3e-67 228.5 0.0 1.9e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 ORX71773.1 - 3.6e-57 193.7 0.0 4.3e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71773.1 - 1.1e-21 77.3 0.0 2.4e-21 76.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71773.1 - 5e-05 22.8 0.0 0.00056 19.3 0.0 2.3 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 ORX71773.1 - 0.002 17.8 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX71773.1 - 0.0055 16.7 2.8 0.13 12.2 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX71773.1 - 0.083 11.8 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Glyco_hydro_15 PF00723.21 ORX71775.1 - 1.1e-27 96.9 1.4 1.2e-13 50.7 0.2 3.0 2 1 1 3 3 3 3 Glycosyl hydrolases family 15 Vac14_Fab1_bd PF12755.7 ORX71776.1 - 5.4e-35 119.9 0.0 4.3e-31 107.4 0.0 2.6 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ORX71776.1 - 3.4e-07 29.9 0.0 0.015 15.5 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ORX71776.1 - 7.1e-07 29.6 0.0 0.026 15.0 0.0 3.2 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 ORX71776.1 - 0.025 15.0 0.0 13 6.2 0.0 3.3 2 1 0 2 2 2 0 HEAT repeats Cnd1 PF12717.7 ORX71776.1 - 0.057 13.5 0.0 8.2 6.4 0.0 2.4 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 AA_permease_2 PF13520.6 ORX71778.1 - 5.8e-21 74.8 32.1 9.5e-17 60.9 32.1 4.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX71778.1 - 1.8e-12 46.6 34.7 5.2e-11 41.8 25.7 4.3 1 1 1 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 ORX71778.1 - 0.02 15.0 9.2 0.02 15.0 9.2 4.9 5 1 0 5 5 5 0 C-terminus of AA_permease DUF4131 PF13567.6 ORX71778.1 - 3.2 7.4 6.7 0.3 10.7 0.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) UCR_6-4kD PF08997.10 ORX71778.1 - 4.8 7.2 7.0 16 5.5 0.0 3.8 4 0 0 4 4 4 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein SprA-related PF12118.8 ORX71781.1 - 1.2 8.2 10.3 1.4 7.9 10.3 1.1 1 0 0 1 1 1 0 SprA-related family MerR-DNA-bind PF09278.11 ORX71783.1 - 0.022 15.3 0.2 0.052 14.1 0.2 1.6 1 0 0 1 1 1 0 MerR, DNA binding Myb_DNA-bind_4 PF13837.6 ORX71784.1 - 0.00089 19.6 0.7 0.0018 18.6 0.7 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 ORX71784.1 - 0.001 19.1 0.3 0.002 18.1 0.3 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain TFIIA PF03153.13 ORX71784.1 - 0.0074 16.3 21.6 0.0093 16.0 21.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pox_MCEL PF03291.16 ORX71785.1 - 2.7e-79 266.7 0.0 4e-79 266.2 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 ORX71785.1 - 8.1e-13 48.9 0.0 1.5e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX71785.1 - 1.2e-09 38.2 0.0 2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX71785.1 - 5.3e-08 33.5 0.0 1.1e-07 32.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX71785.1 - 6.3e-08 33.2 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX71785.1 - 2.2e-07 30.9 0.0 3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ORX71785.1 - 0.0026 17.0 0.0 0.0061 15.8 0.0 1.5 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family Ubie_methyltran PF01209.18 ORX71785.1 - 0.095 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TehB PF03848.14 ORX71785.1 - 0.14 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.14 ORX71785.1 - 0.15 11.6 0.0 0.36 10.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain DUF4097 PF13349.6 ORX71788.1 - 6.2e-05 22.5 2.9 6.2e-05 22.5 2.9 2.2 1 1 0 1 1 1 1 Putative adhesin MSA-2c PF12238.8 ORX71789.1 - 3.8 7.5 7.7 4.1 7.3 7.7 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c Glyco_hydro_3 PF00933.21 ORX71790.1 - 7.1e-51 173.5 0.0 1e-50 172.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ORX71790.1 - 4e-34 118.4 0.0 6.2e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ORX71790.1 - 1.5e-07 31.4 0.0 4.9e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Fibronectin type III-like domain DUF11 PF01345.18 ORX71790.1 - 0.13 12.6 1.4 4.5 7.6 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF11 Mad3_BUB1_I PF08311.12 ORX71792.1 - 5.9e-36 123.2 0.1 1.1e-35 122.3 0.1 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 EBP PF05241.12 ORX71792.1 - 0.00091 18.7 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Emopamil binding protein Mad3_BUB1_I_2 PF17014.5 ORX71792.1 - 0.033 14.3 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein DUF4482 PF14818.6 ORX71792.1 - 0.13 13.1 3.0 0.15 12.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) PBP1_TM PF14812.6 ORX71792.1 - 1.5 9.3 17.1 0.41 11.1 0.8 4.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DEAD PF00270.29 ORX71793.1 - 1.5e-09 37.9 0.1 2.1e-09 37.4 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 ORX71793.1 - 0.00037 20.8 0.0 0.00062 20.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX71793.1 - 0.0045 16.8 0.2 0.11 12.3 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX71793.1 - 0.005 16.9 0.2 0.32 11.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX71793.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 ORX71793.1 - 0.021 14.7 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 ORX71793.1 - 0.021 14.8 0.0 0.035 14.1 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX71793.1 - 0.021 14.3 0.1 0.051 13.0 0.1 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 ORX71793.1 - 0.024 14.9 0.6 0.061 13.6 0.6 1.6 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ORX71793.1 - 0.032 13.3 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 ORX71793.1 - 0.1 12.8 0.6 0.28 11.4 0.2 2.0 2 1 0 2 2 1 0 AAA domain UvrD-helicase PF00580.21 ORX71793.1 - 0.11 12.0 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 ORX71793.1 - 0.12 12.8 0.4 0.19 12.1 0.1 1.6 2 0 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 ORX71793.1 - 0.15 11.9 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ORX71793.1 - 0.16 12.5 0.1 0.29 11.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter RtcR PF06956.11 ORX71793.1 - 0.19 11.2 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase AMP-binding PF00501.28 ORX71794.1 - 1.1e-51 175.8 4.5 1.3e-24 86.6 0.2 3.0 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ORX71794.1 - 0.00045 21.2 0.1 0.0012 19.8 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Alk_phosphatase PF00245.20 ORX71795.1 - 7.1e-106 354.6 0.1 8.5e-106 354.4 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX71795.1 - 0.00013 21.4 0.0 0.00024 20.6 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ORX71795.1 - 0.023 14.1 0.0 0.12 11.7 0.0 2.2 2 1 0 2 2 2 0 Sulfatase Glyco_hydro_3 PF00933.21 ORX71796.1 - 2e-48 165.4 0.0 3e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ORX71796.1 - 2.4e-28 99.5 0.0 4.5e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ORX71796.1 - 1.5e-05 25.0 0.0 3.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain tRNA-synt_1c PF00749.21 ORX71798.1 - 7.4e-106 353.6 0.0 1.3e-105 352.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ORX71798.1 - 3.2e-33 115.1 0.0 6.9e-33 114.0 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 ORX71798.1 - 0.0077 15.6 1.1 0.042 13.2 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain GST_C PF00043.25 ORX71798.1 - 0.071 13.3 0.0 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DapH_N PF08503.10 ORX71798.1 - 0.14 12.4 0.1 0.33 11.2 0.1 1.6 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal Ribophorin_I PF04597.14 ORX71799.1 - 1.2e-74 252.1 0.5 3.2e-74 250.7 0.5 1.6 1 1 0 1 1 1 1 Ribophorin I zf-RING_2 PF13639.6 ORX71800.1 - 3.7e-09 36.8 1.3 5.7e-09 36.2 1.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX71800.1 - 2.6e-08 33.6 1.5 4e-08 33.0 1.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71800.1 - 3.3e-08 33.7 1.7 5e-08 33.1 1.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX71800.1 - 1.6e-07 31.1 0.8 1.6e-07 31.1 0.8 1.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX71800.1 - 2.4e-06 27.3 0.5 3.5e-06 26.8 0.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX71800.1 - 5.9e-06 26.0 0.6 9.6e-06 25.4 0.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX71800.1 - 1.3e-05 25.1 0.5 1.8e-05 24.6 0.5 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX71800.1 - 6.3e-05 22.9 0.4 8.3e-05 22.6 0.4 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ORX71800.1 - 0.00025 20.7 0.2 0.00025 20.7 0.2 2.0 3 0 0 3 3 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 ORX71800.1 - 0.00061 19.4 0.6 0.0011 18.6 0.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 ORX71800.1 - 0.0047 16.9 3.6 0.013 15.5 3.6 1.7 1 1 0 1 1 1 1 Zinc-finger zf-RING_UBOX PF13445.6 ORX71800.1 - 0.0059 16.6 1.8 0.042 13.9 0.1 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING-like PF08746.11 ORX71800.1 - 0.014 15.7 1.3 0.022 15.0 1.3 1.3 1 0 0 1 1 1 0 RING-like domain zf-P11 PF03854.14 ORX71800.1 - 0.017 14.7 1.0 0.025 14.2 1.0 1.3 1 0 0 1 1 1 0 P-11 zinc finger FANCL_C PF11793.8 ORX71800.1 - 0.02 15.0 3.1 0.43 10.8 3.1 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 ORX71800.1 - 0.1 12.8 1.0 0.1 12.8 1.0 1.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ORX71800.1 - 0.12 12.2 1.4 0.12 12.2 0.4 1.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 ORX71805.1 - 1.6e-15 57.2 5.9 1.9e-15 56.9 5.9 1.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX71805.1 - 1.6e-11 43.7 3.3 1.6e-11 43.7 3.3 1.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX71805.1 - 3.8e-11 42.6 6.3 4.9e-11 42.3 6.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX71805.1 - 3.3e-10 39.6 5.0 4.4e-10 39.3 5.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71805.1 - 6.7e-10 39.1 7.1 1.7e-09 37.8 7.1 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX71805.1 - 4.7e-08 32.9 4.3 6e-08 32.5 4.3 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX71805.1 - 7.4e-08 32.3 1.2 7.4e-08 32.3 1.2 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX71805.1 - 8.9e-08 31.9 4.1 1.1e-07 31.6 4.1 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX71805.1 - 6.4e-07 28.9 5.1 8.1e-07 28.6 5.1 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ORX71805.1 - 3e-06 27.0 5.4 4.2e-06 26.5 5.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX71805.1 - 1.3e-05 25.2 3.6 2e-05 24.5 3.5 1.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 ORX71805.1 - 0.00021 21.1 3.8 0.0003 20.6 3.8 1.3 1 0 0 1 1 1 1 PHD-finger RINGv PF12906.7 ORX71805.1 - 0.00023 21.2 3.3 0.00059 19.9 3.3 1.6 1 1 0 1 1 1 1 RING-variant domain zf-RING-like PF08746.11 ORX71805.1 - 0.0026 18.0 6.1 0.0037 17.5 5.9 1.5 1 1 0 1 1 1 1 RING-like domain zf-C3HC4_4 PF15227.6 ORX71805.1 - 0.0043 17.2 4.8 0.015 15.4 4.7 1.8 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ORX71805.1 - 0.0072 16.1 2.9 0.016 15.0 2.9 1.6 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 ORX71805.1 - 0.0089 15.8 4.2 0.013 15.3 4.2 1.3 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zf_RING PF16744.5 ORX71805.1 - 0.012 15.7 4.2 0.026 14.6 4.2 1.6 1 1 0 1 1 1 0 KIAA1045 RING finger Rtf2 PF04641.12 ORX71805.1 - 0.038 13.4 1.5 0.044 13.1 1.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger FANCL_C PF11793.8 ORX71805.1 - 0.054 13.7 6.9 0.6 10.3 6.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain C1_1 PF00130.22 ORX71805.1 - 0.06 13.2 5.6 0.059 13.3 1.3 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3H2C3 PF17122.5 ORX71805.1 - 0.18 11.8 10.7 0.53 10.4 10.3 2.1 1 1 0 1 1 1 0 Zinc-finger GAGA PF09237.11 ORX71805.1 - 0.32 10.8 2.7 7.7 6.4 0.0 2.3 2 1 0 2 2 2 0 GAGA factor Vps39_2 PF10367.9 ORX71805.1 - 0.45 11.0 5.6 0.18 12.3 1.5 1.9 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF5351 PF17302.2 ORX71805.1 - 2.1 8.6 5.2 3.4 7.9 1.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5351) zf-RING_2 PF13639.6 ORX71806.1 - 2.9e-12 46.7 9.5 4.7e-12 46.0 9.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX71806.1 - 4.7e-09 35.9 9.9 9e-09 35.0 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71806.1 - 6.9e-09 35.9 10.0 2.4e-08 34.2 10.0 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX71806.1 - 3.2e-08 33.3 9.3 5.4e-08 32.6 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX71806.1 - 3.5e-08 33.1 5.4 6.5e-08 32.2 5.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX71806.1 - 1.9e-07 31.0 6.9 2.9e-07 30.4 4.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX71806.1 - 3.4e-06 26.9 7.4 6.9e-06 25.9 7.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX71806.1 - 7.1e-06 25.8 4.5 1.2e-05 25.1 4.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX71806.1 - 2.9e-05 24.0 6.2 6.3e-05 22.9 6.2 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ORX71806.1 - 0.00015 21.8 4.1 0.00038 20.5 4.1 1.7 1 1 0 1 1 1 1 RING-variant domain zf-Nse PF11789.8 ORX71806.1 - 0.0019 18.0 3.8 0.0038 17.0 3.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 ORX71806.1 - 0.0039 16.8 5.1 0.0084 15.7 5.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX71806.1 - 0.035 14.3 9.9 0.078 13.2 9.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 ORX71806.1 - 0.04 14.1 7.1 0.27 11.5 7.1 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain U-box PF04564.15 ORX71806.1 - 0.12 12.6 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-RING-like PF08746.11 ORX71806.1 - 0.4 11.0 9.0 0.85 10.0 9.0 1.7 1 1 0 1 1 1 0 RING-like domain zf-C3H2C3 PF17122.5 ORX71806.1 - 0.46 10.6 9.1 1.7 8.7 9.1 2.1 1 1 0 1 1 1 0 Zinc-finger Prok-RING_4 PF14447.6 ORX71806.1 - 0.76 9.7 12.2 5.3 7.0 10.9 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PHD PF00628.29 ORX71806.1 - 0.88 9.5 6.8 1.9 8.4 6.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 ORX71806.1 - 1.1 9.1 6.6 2.2 8.1 6.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 ORX71807.1 - 3.9e-13 49.5 6.1 6.4e-13 48.8 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX71807.1 - 1.2e-10 40.9 2.4 2.3e-10 40.0 2.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX71807.1 - 4.2e-10 39.3 6.5 7.4e-10 38.5 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX71807.1 - 8.6e-08 31.9 7.1 1.4e-07 31.2 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71807.1 - 8.6e-08 32.4 8.0 2.9e-07 30.7 8.0 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX71807.1 - 2e-05 24.4 4.6 3.4e-05 23.7 4.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX71807.1 - 3.8e-05 23.6 1.9 0.00024 21.1 2.3 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX71807.1 - 4.6e-05 23.2 4.0 7e-05 22.6 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX71807.1 - 9.4e-05 22.4 4.1 0.0004 20.4 4.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 ORX71807.1 - 0.0024 17.6 6.0 0.0042 16.8 6.0 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 ORX71807.1 - 0.0026 17.6 4.5 0.007 16.2 4.6 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ORX71807.1 - 0.0029 17.2 4.1 0.0053 16.4 4.1 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX71807.1 - 0.0036 17.4 7.9 0.0036 17.4 7.9 1.8 2 0 0 2 2 1 1 RING-variant domain zf-RING-like PF08746.11 ORX71807.1 - 0.0071 16.6 2.7 0.016 15.5 2.7 1.5 1 0 0 1 1 1 1 RING-like domain PHD PF00628.29 ORX71807.1 - 0.014 15.3 6.2 0.023 14.6 6.2 1.4 1 0 0 1 1 1 0 PHD-finger zf-UDP PF14569.6 ORX71807.1 - 0.071 13.2 1.0 0.16 12.1 1.0 1.5 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 ORX71807.1 - 0.075 13.2 4.5 0.21 11.8 4.5 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Phi_1 PF04674.12 ORX71807.1 - 0.12 11.7 0.3 0.18 11.1 0.3 1.1 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region Peptidase_C5 PF00770.18 ORX71807.1 - 0.14 11.8 0.1 2.1 8.0 0.0 2.1 1 1 1 2 2 2 0 Adenovirus endoprotease zf-Nse PF11789.8 ORX71807.1 - 0.17 11.7 3.9 0.31 10.9 3.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.14 ORX71807.1 - 0.21 11.3 6.1 0.65 9.7 6.1 1.8 1 1 0 1 1 1 0 P-11 zinc finger FANCL_C PF11793.8 ORX71807.1 - 0.28 11.4 7.3 1.8 8.8 7.3 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Baculo_RING PF05883.11 ORX71807.1 - 0.31 11.0 1.2 0.62 10.1 1.2 1.5 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain Prok-RING_1 PF14446.6 ORX71807.1 - 0.69 9.9 5.0 1.8 8.5 1.6 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3H2C3 PF17122.5 ORX71807.1 - 2.2 8.4 10.9 0.76 9.9 7.4 2.2 2 1 0 2 2 1 0 Zinc-finger SET_assoc PF11767.8 ORX71808.1 - 0.023 14.3 0.1 0.085 12.5 0.0 1.9 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated zf-RING_2 PF13639.6 ORX71809.1 - 6e-12 45.7 4.3 1.1e-11 44.8 4.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX71809.1 - 9.4e-09 34.9 0.9 2.7e-08 33.4 0.9 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX71809.1 - 7e-08 32.2 4.9 1.3e-07 31.3 4.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71809.1 - 1.3e-06 28.6 5.3 4e-06 27.0 5.3 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX71809.1 - 1.7e-06 27.8 2.9 1.7e-06 27.8 2.9 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX71809.1 - 1.8e-06 27.8 2.6 3.4e-06 26.9 2.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX71809.1 - 4.4e-06 26.5 2.9 9.2e-06 25.4 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX71809.1 - 0.00086 18.9 3.6 0.002 17.7 3.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ORX71809.1 - 0.0012 18.8 3.1 0.0032 17.5 3.1 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX71809.1 - 0.0015 18.5 2.9 0.0028 17.6 1.1 2.3 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX71809.1 - 0.0028 17.5 2.9 0.0064 16.3 2.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4748 PF15932.5 ORX71809.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) zf-P11 PF03854.14 ORX71809.1 - 0.031 13.9 3.0 0.059 13.0 3.0 1.5 1 0 0 1 1 1 0 P-11 zinc finger PHD PF00628.29 ORX71809.1 - 0.041 13.8 5.0 0.11 12.4 5.0 1.8 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 ORX71809.1 - 0.14 12.1 6.9 0.6 10.1 2.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 ORX71809.1 - 0.14 12.0 4.7 0.3 10.9 4.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain AmpE PF17113.5 ORX71809.1 - 0.15 11.4 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE zf-C3H2C3 PF17122.5 ORX71809.1 - 0.15 12.1 4.5 0.4 10.7 4.5 1.8 1 1 0 1 1 1 0 Zinc-finger zf-C3HC4_4 PF15227.6 ORX71809.1 - 0.27 11.4 3.7 1 9.5 3.7 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING C1_1 PF00130.22 ORX71809.1 - 0.29 11.0 3.8 2.9 7.9 0.4 2.6 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Nse PF11789.8 ORX71809.1 - 1.5 8.7 4.6 13 5.7 1.6 2.3 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 ORX71809.1 - 1.8 8.7 8.4 0.41 10.8 3.9 2.3 2 1 0 2 2 2 0 RING-variant domain zf-RING-like PF08746.11 ORX71809.1 - 2.1 8.7 5.8 0.48 10.8 1.7 2.1 2 0 0 2 2 1 0 RING-like domain zf-RING_2 PF13639.6 ORX71810.1 - 9.7e-13 48.2 6.3 1.6e-12 47.5 6.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX71810.1 - 2.1e-10 40.3 6.7 3.4e-10 39.6 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX71810.1 - 2.3e-10 40.1 3.5 5.5e-10 38.8 3.5 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX71810.1 - 6.1e-10 38.8 6.3 1e-09 38.1 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX71810.1 - 1e-08 35.3 8.2 5e-08 33.1 8.2 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ORX71810.1 - 4.1e-06 26.6 3.5 7.1e-06 25.8 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX71810.1 - 4.3e-05 23.1 2.6 9.1e-05 22.0 2.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ORX71810.1 - 6.7e-05 22.9 3.1 0.00021 21.3 3.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX71810.1 - 0.00011 22.2 1.3 0.00041 20.3 1.6 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX71810.1 - 0.00014 21.7 4.0 0.00025 20.9 4.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING-like PF08746.11 ORX71810.1 - 0.00097 19.4 4.6 0.0017 18.6 4.6 1.5 1 0 0 1 1 1 1 RING-like domain RINGv PF12906.7 ORX71810.1 - 0.0049 17.0 6.4 0.011 15.9 6.4 1.6 1 0 0 1 1 1 1 RING-variant domain Prok-RING_4 PF14447.6 ORX71810.1 - 0.0049 16.7 2.4 0.012 15.5 2.4 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 YtpI PF14007.6 ORX71810.1 - 0.011 15.9 0.1 4.8 7.4 0.3 2.8 3 0 0 3 3 3 0 YtpI-like protein zf-C3H2C3 PF17122.5 ORX71810.1 - 0.044 13.8 3.2 0.14 12.3 3.2 1.9 1 1 0 1 1 1 0 Zinc-finger zf-HC5HC2H PF13771.6 ORX71810.1 - 0.074 13.3 0.6 0.074 13.3 0.6 1.8 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING_4 PF14570.6 ORX71810.1 - 0.075 12.8 5.0 0.14 12.0 5.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ORX71810.1 - 0.098 12.8 5.3 0.17 12.0 5.3 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 ORX71810.1 - 0.16 12.2 5.8 0.74 10.0 5.8 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 ORX71810.1 - 0.24 11.2 2.7 0.43 10.4 2.7 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Scramblase PF03803.15 ORX71811.1 - 2.3e-50 171.0 0.1 2.6e-50 170.8 0.1 1.0 1 0 0 1 1 1 1 Scramblase HPIH PF13323.6 ORX71812.1 - 0.087 12.7 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 N-terminal domain with HPIH motif DUF1664 PF07889.12 ORX71812.1 - 0.18 11.9 7.5 0.24 11.5 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MbeD_MobD PF04899.12 ORX71812.1 - 0.42 10.8 4.5 2 8.6 4.5 2.3 1 0 0 1 1 1 0 MbeD/MobD like Fez1 PF06818.15 ORX71812.1 - 0.49 10.8 24.6 0.57 10.6 10.2 2.3 2 0 0 2 2 2 0 Fez1 ABC_tran_CTD PF16326.5 ORX71812.1 - 0.58 10.5 12.6 23 5.3 7.6 4.0 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF4665 PF15679.5 ORX71812.1 - 1.1 9.9 3.9 2.6 8.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) THOC7 PF05615.13 ORX71812.1 - 1.7 8.9 15.0 1.5 9.1 8.1 2.6 2 0 0 2 2 2 0 Tho complex subunit 7 HAUS6_N PF14661.6 ORX71812.1 - 1.8 8.1 12.5 0.24 10.9 4.6 2.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Laminin_II PF06009.12 ORX71812.1 - 3.8 7.5 11.9 7 6.7 2.0 2.9 2 1 1 3 3 3 0 Laminin Domain II KxDL PF10241.9 ORX71812.1 - 4.4 7.6 14.5 1.6 9.1 2.6 3.5 2 1 0 3 3 3 0 Uncharacterized conserved protein DUF724 PF05266.14 ORX71812.1 - 4.8 7.0 14.0 0.89 9.4 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) WXG100 PF06013.12 ORX71812.1 - 5.4 7.3 6.6 1.8 8.8 0.5 3.1 3 0 0 3 3 3 0 Proteins of 100 residues with WXG zf-CpG_bind_C PF12269.8 ORX71812.1 - 5.9 6.6 7.2 0.45 10.3 1.5 2.0 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain GAS PF13851.6 ORX71812.1 - 8.3 5.7 11.7 1.8 7.9 4.7 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Synaptobrevin PF00957.21 ORX71813.1 - 4.1e-14 52.1 0.6 6.6e-14 51.5 0.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ORX71813.1 - 1.5e-09 37.8 0.0 3.3e-09 36.6 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain Lactamase_B PF00753.27 ORX71815.1 - 2.9e-16 60.0 1.1 1.4e-15 57.8 1.1 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily TPR_2 PF07719.17 ORX71815.1 - 0.0041 17.1 0.1 0.011 15.8 0.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat Lactamase_B_2 PF12706.7 ORX71815.1 - 0.0046 16.5 0.6 0.011 15.3 0.6 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain TPR_1 PF00515.28 ORX71815.1 - 0.078 12.8 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX71815.1 - 0.13 12.5 0.2 0.31 11.4 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Methyltransf_23 PF13489.6 ORX71817.1 - 1.1e-19 70.9 0.0 2.2e-19 69.9 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX71817.1 - 4.8e-19 68.8 0.1 9e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX71817.1 - 1.3e-15 57.8 0.2 2.6e-15 56.9 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX71817.1 - 1.3e-13 51.0 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX71817.1 - 3.6e-13 50.1 0.1 6.5e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX71817.1 - 7.1e-09 35.3 0.0 9e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 ORX71817.1 - 5.5e-07 28.8 0.0 7.5e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 ORX71817.1 - 9.3e-06 25.2 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 ORX71817.1 - 1.5e-05 24.7 0.1 2.1e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 ORX71817.1 - 5.8e-05 22.7 0.0 9.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX71817.1 - 0.00066 19.7 0.0 0.00097 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX71817.1 - 0.0079 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 ORX71817.1 - 0.012 15.0 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 ORX71817.1 - 0.025 14.1 0.1 0.04 13.5 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TPMT PF05724.11 ORX71817.1 - 0.033 13.8 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DEAD PF00270.29 ORX71818.1 - 3.5e-17 62.7 0.0 6.5e-17 61.8 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX71818.1 - 2e-11 44.2 0.0 4.8e-11 43.0 0.0 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX71818.1 - 9e-08 32.3 0.0 1.7e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DmpG_comm PF07836.11 ORX71818.1 - 0.07 12.7 0.0 0.46 10.0 0.0 2.3 2 0 0 2 2 2 0 DmpG-like communication domain AAA_22 PF13401.6 ORX71818.1 - 0.083 13.2 0.0 0.32 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX71818.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 ORX71818.1 - 0.15 11.5 0.4 0.56 9.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein p450 PF00067.22 ORX71819.1 - 2.5e-40 138.6 0.1 2.9e-30 105.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 p450 PF00067.22 ORX71820.1 - 5.5e-11 41.9 0.0 1.3e-09 37.3 0.0 2.5 3 0 0 3 3 3 2 Cytochrome P450 POP1 PF06978.11 ORX71821.1 - 1.4e-45 155.8 18.1 2.4e-25 89.8 8.2 2.5 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 ORX71821.1 - 6.9e-25 87.2 4.6 2.6e-24 85.3 0.2 2.9 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T PF01571.21 ORX71821.1 - 0.00035 20.0 0.3 0.61 9.4 0.1 2.6 3 0 0 3 3 3 2 Aminomethyltransferase folate-binding domain DUF3161 PF11362.8 ORX71821.1 - 0.21 11.6 0.1 0.62 10.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3161) AA_permease_2 PF13520.6 ORX71825.1 - 2.6e-46 158.3 47.8 3.4e-46 158.0 47.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX71825.1 - 2.1e-28 99.2 48.1 6.6e-28 97.5 48.1 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 ORX71825.1 - 0.00024 21.1 4.4 0.00024 21.1 4.4 3.4 4 0 0 4 4 4 1 C-terminus of AA_permease Prp18 PF02840.15 ORX71826.1 - 1.6e-56 190.4 1.5 2.1e-56 190.0 0.1 1.9 2 0 0 2 2 2 1 Prp18 domain Pep1_7 PF17232.2 ORX71827.1 - 0.11 12.9 0.2 0.21 12.1 0.2 1.3 1 0 0 1 1 1 0 Elicitor peptide 1-7 DUF3419 PF11899.8 ORX71830.1 - 7.5e-108 361.1 0.1 2.7e-107 359.3 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 ORX71830.1 - 5e-09 36.2 0.0 1.1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX71830.1 - 1.5e-08 35.2 0.0 2.3e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX71830.1 - 2e-07 31.5 0.0 6.2e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX71830.1 - 4e-06 27.5 0.0 9.7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX71830.1 - 4.7e-05 22.8 0.0 8.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX71830.1 - 0.00025 20.9 0.0 0.00081 19.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 ORX71830.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PH PF00169.29 ORX71832.1 - 0.001 19.6 0.0 0.047 14.2 0.0 2.7 2 1 0 2 2 2 1 PH domain FERM_f0 PF16511.5 ORX71832.1 - 0.0028 17.9 0.0 0.0063 16.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM MFS_1 PF07690.16 ORX71833.1 - 2.2e-15 56.5 52.3 2.2e-15 56.4 49.6 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily 7tm_7 PF08395.12 ORX71833.1 - 0.014 14.7 0.1 0.035 13.3 0.1 1.6 1 0 0 1 1 1 0 7tm Chemosensory receptor BolA PF01722.18 ORX71834.1 - 4.6e-27 94.1 1.2 5.4e-27 93.9 1.2 1.1 1 0 0 1 1 1 1 BolA-like protein Sec34 PF04136.15 ORX71835.1 - 1.2e-29 103.1 0.0 5.2e-29 101.1 0.0 2.0 2 0 0 2 2 2 1 Sec34-like family Ribosomal_S2 PF00318.20 ORX71836.1 - 2.2e-58 197.1 0.0 4.6e-58 196.0 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S2 p450 PF00067.22 ORX71839.1 - 1.1e-54 186.0 0.0 1.4e-54 185.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC_membrane PF00664.23 ORX71840.1 - 0.00091 19.0 0.0 0.00091 19.0 0.0 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region 12TM_1 PF09847.9 ORX71840.1 - 0.031 13.4 1.5 0.035 13.2 1.5 1.0 1 0 0 1 1 1 0 Membrane protein of 12 TMs FeoA PF04023.14 ORX71841.1 - 0.19 12.0 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 FeoA domain Phage_int_SAM_4 PF13495.6 ORX71842.1 - 0.15 12.5 0.0 0.34 11.4 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Rad52_Rad22 PF04098.15 ORX71843.1 - 1.6e-53 180.7 0.0 2.4e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein PRTP PF01366.18 ORX71843.1 - 0.087 10.9 0.2 0.14 10.2 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Pup PF05639.11 ORX71843.1 - 2.5 9.1 4.5 0.78 10.7 0.4 2.3 2 0 0 2 2 2 0 Pup-like protein mRNA_cap_enzyme PF01331.19 ORX71844.1 - 9e-51 172.5 0.1 1.1e-50 172.2 0.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ORX71844.1 - 3.6e-23 82.2 0.0 6.1e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ORX71844.1 - 3.1e-08 33.5 0.0 0.0008 19.1 0.0 2.2 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Chitin_synth_2 PF03142.15 ORX71845.1 - 8.2e-158 526.3 9.9 8.8e-158 526.2 7.2 1.9 2 0 0 2 2 2 1 Chitin synthase DEK_C PF08766.11 ORX71845.1 - 8.3e-18 64.1 0.1 4.9e-17 61.6 0.3 2.0 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 ORX71845.1 - 3e-10 40.3 10.3 1.1e-09 38.5 10.3 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX71845.1 - 1.2e-08 35.1 0.0 2.4e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ORX71845.1 - 0.0098 15.7 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Sugar_tr PF00083.24 ORX71847.1 - 2.1e-92 310.3 22.1 2.6e-92 310.0 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX71847.1 - 7.8e-28 97.4 71.3 2.5e-24 85.9 39.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4064 PF13273.6 ORX71847.1 - 0.024 14.9 3.3 0.024 14.9 3.3 4.5 3 3 1 4 4 4 0 Protein of unknown function (DUF4064) p450 PF00067.22 ORX71848.1 - 5.3e-68 229.9 0.0 1.3e-60 205.4 0.0 2.1 1 1 0 2 2 2 2 Cytochrome P450 FAD_binding_1 PF00667.20 ORX71848.1 - 4.2e-29 101.7 0.0 7.7e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX71848.1 - 3.5e-22 79.2 0.1 7.4e-22 78.1 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX71848.1 - 1.7e-16 60.8 0.0 3.3e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Abhydrolase_1 PF00561.20 ORX71849.1 - 7.3e-09 35.6 0.0 1.9e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX71849.1 - 0.00022 20.6 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX71849.1 - 0.00059 20.5 0.0 0.00094 19.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PDZ_6 PF17820.1 ORX71850.1 - 5.7e-15 54.9 1.9 0.00018 21.3 0.1 4.5 4 0 0 4 4 4 4 PDZ domain Trypsin_2 PF13365.6 ORX71850.1 - 8.8e-14 52.7 0.3 5.8e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_1 PF12812.7 ORX71850.1 - 1.6e-11 44.0 0.0 6.2e-06 26.1 0.0 3.4 2 1 0 2 2 2 2 PDZ-like domain PDZ_2 PF13180.6 ORX71850.1 - 1.1e-10 41.7 0.1 4.1e-06 27.0 0.0 4.0 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 ORX71850.1 - 2.9e-07 30.7 2.6 0.00035 20.9 0.0 2.9 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 ORX71850.1 - 0.012 15.5 0.9 5.5 7.0 0.0 3.3 3 0 0 3 3 3 0 Tricorn protease PDZ domain PRCC PF10253.9 ORX71852.1 - 9.2 7.0 10.3 12 6.6 10.3 1.3 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Arf PF00025.21 ORX71854.1 - 2.2e-77 258.4 0.0 2.6e-77 258.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX71854.1 - 6.4e-15 55.4 0.0 8.5e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX71854.1 - 3.7e-13 49.4 0.0 4.3e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ORX71854.1 - 2.3e-11 43.5 0.4 5.4e-07 29.1 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX71854.1 - 1e-10 41.4 0.0 1.2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX71854.1 - 1.4e-08 34.4 0.0 1.8e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX71854.1 - 1.8e-05 24.8 0.0 2.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 ORX71854.1 - 0.00075 18.6 0.1 0.02 13.9 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 ORX71854.1 - 0.0014 18.2 0.0 0.014 15.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ORX71854.1 - 0.0063 17.1 0.0 0.0094 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX71854.1 - 0.015 15.8 0.3 0.094 13.2 0.3 1.9 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 ORX71854.1 - 0.053 13.1 0.1 8.8 5.9 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 ORX71854.1 - 0.076 12.5 0.4 0.32 10.5 0.4 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Herpes_UL36 PF03586.13 ORX71855.1 - 0.14 11.5 0.4 0.22 10.8 0.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein GATA PF00320.27 ORX71857.1 - 1.4e-19 69.3 3.4 1.8e-19 69.1 3.4 1.1 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ORX71857.1 - 0.14 12.3 0.4 0.18 12.0 0.4 1.2 1 0 0 1 1 1 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 ORX71857.1 - 0.19 11.3 1.6 0.29 10.7 1.6 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding adh_short PF00106.25 ORX71858.1 - 1.4e-44 151.9 0.0 1.6e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX71858.1 - 9.6e-30 103.9 0.0 1.2e-29 103.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX71858.1 - 2.6e-08 34.0 0.1 3.5e-08 33.5 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX71858.1 - 0.0011 18.4 0.0 0.0053 16.3 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ORX71858.1 - 0.0061 16.5 0.1 0.016 15.1 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 ORX71858.1 - 0.14 11.5 0.6 0.31 10.3 0.2 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DSBA PF01323.20 ORX71861.1 - 4.3e-26 91.9 0.0 4.8e-26 91.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Pacifastin_I PF05375.13 ORX71862.1 - 9.1e-16 57.3 26.8 2.1e-07 30.5 2.1 4.3 4 0 0 4 4 4 4 Pacifastin inhibitor (LCMII) ABC2_membrane PF01061.24 ORX71863.1 - 5.9e-69 231.7 51.6 1.9e-36 125.5 17.9 3.1 3 1 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 ORX71863.1 - 5.4e-38 130.6 0.0 1.6e-19 70.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ORX71863.1 - 4.7e-12 45.7 14.5 1.9e-05 24.5 0.3 4.3 3 1 1 4 4 4 3 CDR ABC transporter AAA_29 PF13555.6 ORX71863.1 - 1e-05 25.2 2.5 0.0028 17.4 0.6 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX71863.1 - 2.3e-05 24.8 0.7 0.082 13.3 0.0 3.0 2 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX71863.1 - 2.4e-05 24.3 0.2 0.0012 18.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 ORX71863.1 - 3.3e-05 23.8 0.0 0.036 13.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX71863.1 - 8.9e-05 22.8 0.1 0.049 13.9 0.1 2.9 3 1 0 3 3 2 1 AAA domain AAA_25 PF13481.6 ORX71863.1 - 0.00033 20.3 0.0 0.0076 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX71863.1 - 0.004 17.3 0.2 0.89 9.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ORX71863.1 - 0.0075 16.2 0.1 0.42 10.5 0.0 2.7 2 0 0 2 2 2 1 NACHT domain COX14 PF14880.6 ORX71863.1 - 0.0083 15.9 0.5 1.8 8.4 0.1 2.9 2 0 0 2 2 2 1 Cytochrome oxidase c assembly AAA_13 PF13166.6 ORX71863.1 - 0.0093 14.7 1.8 0.76 8.3 0.0 2.7 3 0 0 3 3 3 1 AAA domain SMC_N PF02463.19 ORX71863.1 - 0.018 14.5 0.1 0.17 11.3 0.1 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 ORX71863.1 - 0.019 14.5 0.5 0.13 11.8 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ORX71863.1 - 0.032 14.8 0.1 8.9 6.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX71863.1 - 0.039 13.2 0.1 3.5 6.8 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ORX71863.1 - 0.042 13.6 0.1 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3846 PF12957.7 ORX71863.1 - 0.099 13.0 0.0 8.8 6.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) AAA_28 PF13521.6 ORX71863.1 - 0.14 12.4 0.6 0.98 9.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ORX71863.1 - 0.77 8.8 46.1 0.012 14.8 7.3 3.5 3 1 1 4 4 4 0 ABC-2 family transporter protein AAA_23 PF13476.6 ORX71863.1 - 0.91 10.0 2.6 0.63 10.5 0.1 1.9 2 0 0 2 2 2 0 AAA domain Inhibitor_I78 PF11720.8 ORX71864.1 - 3.4e-10 39.8 0.0 4.8e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX71864.1 - 0.0014 19.2 0.1 0.0026 18.4 0.1 1.4 1 0 0 1 1 1 1 Potato inhibitor I family GRIM-19 PF06212.12 ORX71865.1 - 3.1e-33 114.5 0.0 3.4e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein SIKE PF05769.11 ORX71866.1 - 0.0049 16.8 7.5 1.7 8.6 0.1 3.1 2 1 0 3 3 3 2 SIKE family Herpes_BLRF2 PF05812.12 ORX71866.1 - 0.026 14.7 5.7 0.33 11.1 0.4 2.9 2 1 0 3 3 3 0 Herpesvirus BLRF2 protein Med19 PF10278.9 ORX71866.1 - 0.036 14.0 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CdvA PF18822.1 ORX71866.1 - 0.04 13.7 9.0 1.3 8.9 2.4 2.7 2 1 1 3 3 3 0 CdvA-like coiled-coil domain CCD48 PF15799.5 ORX71866.1 - 0.042 12.2 9.6 0.068 11.5 6.3 1.9 1 1 0 2 2 2 0 Coiled-coil domain-containing protein 48 UPF0449 PF15136.6 ORX71866.1 - 0.083 13.4 4.2 1.4 9.5 0.0 3.1 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Tup_N PF08581.10 ORX71866.1 - 0.11 12.8 7.9 2.7 8.4 0.0 3.3 2 1 0 3 3 3 0 Tup N-terminal YkyA PF10368.9 ORX71866.1 - 0.11 12.1 9.2 0.018 14.7 2.2 2.1 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Rx_N PF18052.1 ORX71866.1 - 0.12 12.7 1.6 1.4 9.3 0.1 2.3 2 0 0 2 2 2 0 Rx N-terminal domain Seryl_tRNA_N PF02403.22 ORX71866.1 - 0.27 11.5 0.2 0.27 11.5 0.2 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TSC22 PF01166.18 ORX71866.1 - 0.53 10.6 2.6 11 6.5 0.0 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family YabA PF06156.13 ORX71866.1 - 1.2 9.8 6.5 35 5.1 0.2 3.1 2 1 1 3 3 3 0 Initiation control protein YabA Dscam_C PF12355.8 ORX71866.1 - 7.1 7.6 16.2 11 7.1 1.9 2.4 1 1 1 2 2 2 0 Down syndrome cell adhesion molecule C terminal PRIMA1 PF16101.5 ORX71866.1 - 8.1 6.5 7.8 2.1 8.4 4.1 1.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF5094 PF17015.5 ORX71866.1 - 9.2 6.3 6.0 0.95 9.6 0.9 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5094) FlxA PF14282.6 ORX71866.1 - 9.6 6.3 9.4 1.1 9.3 0.4 2.9 3 0 0 3 3 3 0 FlxA-like protein Porphobil_deam PF01379.20 ORX71867.1 - 3e-77 258.8 0.8 3.9e-77 258.4 0.8 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ORX71867.1 - 2.4e-18 66.3 0.4 4.5e-18 65.4 0.4 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain LRR_6 PF13516.6 ORX71867.1 - 0.077 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Leucine Rich repeat Mak10 PF04112.13 ORX71868.1 - 6.7e-33 113.6 0.6 1.2e-32 112.7 0.6 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ANTH PF07651.16 ORX71869.1 - 6.8e-64 215.5 0.0 6.8e-64 215.5 0.0 3.4 2 1 1 3 3 3 1 ANTH domain I_LWEQ PF01608.17 ORX71869.1 - 6.3e-50 169.4 14.1 6.3e-50 169.4 14.1 6.2 3 2 2 6 6 6 1 I/LWEQ domain GATA PF00320.27 ORX71869.1 - 2.3e-13 49.5 3.8 4e-13 48.7 3.8 1.4 1 0 0 1 1 1 1 GATA zinc finger TcdB_N PF12918.7 ORX71869.1 - 0.061 13.6 1.5 0.27 11.5 1.5 2.2 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain FAA_hydro_N_2 PF18288.1 ORX71869.1 - 0.17 12.3 6.9 0.064 13.7 1.4 3.4 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 TF_Zn_Ribbon PF08271.12 ORX71869.1 - 0.46 10.0 1.6 0.92 9.1 1.6 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.12 ORX71869.1 - 0.96 9.8 3.4 2 8.8 3.4 1.4 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase p450 PF00067.22 ORX71870.1 - 2.2e-76 257.5 0.0 2.8e-76 257.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_4 PF01063.19 ORX71871.1 - 2.8e-32 112.4 0.0 3.6e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV DUF4112 PF13430.6 ORX71872.1 - 1.9e-06 28.1 0.4 2.6e-06 27.6 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF4112 PF13430.6 ORX71873.1 - 8.1e-05 22.8 0.0 0.00013 22.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF4112 PF13430.6 ORX71874.1 - 0.0015 18.8 0.2 0.0026 18.0 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) CBM_14 PF01607.24 ORX71876.1 - 2.7e-12 46.6 4.5 3.2e-12 46.4 4.5 1.1 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain Cyt-b5 PF00173.28 ORX71877.1 - 6.6e-13 48.6 0.0 8.1e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DNA_pol_A_exo1 PF01612.20 ORX71878.1 - 3e-38 131.3 0.3 4.9e-38 130.6 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 ORX71878.1 - 1.2e-14 54.0 0.0 5.5e-14 51.9 0.0 2.3 2 0 0 2 2 2 1 HRDC domain PMC2NT PF08066.12 ORX71878.1 - 1.5e-14 54.5 0.0 4.7e-14 52.8 0.0 2.0 2 0 0 2 2 2 1 PMC2NT (NUC016) domain BCIP PF13862.6 ORX71879.1 - 2.3e-35 122.2 0.3 1.7e-29 103.1 0.0 2.2 2 0 0 2 2 2 2 p21-C-terminal region-binding protein Sugar_tr PF00083.24 ORX71880.1 - 5.1e-39 134.4 19.4 3.9e-36 124.9 14.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX71880.1 - 1.9e-23 82.9 18.3 4.2e-21 75.3 4.9 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF389 PF04087.14 ORX71880.1 - 0.23 11.5 4.1 5.6 7.0 0.0 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF389) MFS_4 PF06779.14 ORX71880.1 - 0.32 10.2 10.4 0.1 11.9 6.1 2.1 2 1 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ORX71881.1 - 5e-28 98.2 17.9 9.6e-27 93.9 17.9 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX71881.1 - 1.6e-22 79.9 20.2 5.9e-22 78.1 20.1 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ORX71881.1 - 0.029 13.2 10.2 0.32 9.8 0.9 2.2 2 0 0 2 2 2 0 MFS_1 like family WW PF00397.26 ORX71883.1 - 2.8e-09 36.9 0.0 6.2e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 WW domain DUF2457 PF10446.9 ORX71883.1 - 0.016 14.4 5.0 0.017 14.3 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pro-rich PF15240.6 ORX71883.1 - 0.069 13.4 37.2 0.091 13.0 37.2 1.2 1 0 0 1 1 1 0 Proline-rich TFIIA PF03153.13 ORX71883.1 - 2 8.3 13.6 2.2 8.2 13.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Extensin_2 PF04554.13 ORX71883.1 - 3.2 7.9 58.6 8.6 6.5 54.6 2.7 2 1 0 2 2 2 0 Extensin-like region RRM_1 PF00076.22 ORX71884.1 - 5e-05 23.0 0.0 7.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1388 PF07142.12 ORX71884.1 - 0.0025 17.7 25.8 0.1 12.5 11.5 4.0 2 1 1 3 3 3 2 Repeat of unknown function (DUF1388) DUF963 PF06131.11 ORX71884.1 - 0.29 10.6 16.7 0.96 8.9 7.8 2.4 1 1 1 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) OPT PF03169.15 ORX71885.1 - 3.7e-129 432.1 43.4 9.2e-127 424.2 43.4 2.1 1 1 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 ORX71885.1 - 0.35 10.2 0.9 0.99 8.7 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3093 PF11292.8 ORX71885.1 - 1.3 9.3 7.1 0.47 10.7 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) PsbM PF05151.12 ORX71885.1 - 5.1 7.0 8.8 0.17 11.7 0.3 2.5 2 0 0 2 2 2 0 Photosystem II reaction centre M protein (PsbM) DnaJ PF00226.31 ORX71888.1 - 2.7e-14 53.0 0.4 6.1e-14 51.9 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain LapA_dom PF06305.11 ORX71888.1 - 0.16 11.8 0.1 0.16 11.8 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Ras PF00071.22 ORX71891.1 - 6.1e-56 188.5 0.2 6.1e-56 188.5 0.2 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ORX71891.1 - 1.5e-36 125.2 0.1 1.5e-36 125.2 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX71891.1 - 9.4e-18 64.3 0.2 1.3e-17 63.8 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX71891.1 - 4.2e-06 26.4 0.5 8.8e-06 25.4 0.3 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX71891.1 - 2.5e-05 23.8 0.0 3.6e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX71891.1 - 3.1e-05 23.5 0.0 5.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX71891.1 - 5e-05 23.4 0.0 8.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX71891.1 - 0.0012 18.8 0.1 0.12 12.3 0.0 2.5 1 1 1 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ORX71891.1 - 0.0049 17.3 0.0 0.012 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ORX71891.1 - 0.038 14.0 0.1 0.075 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ORX71891.1 - 0.043 14.3 0.9 0.13 12.7 0.9 1.8 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ORX71891.1 - 0.046 14.0 0.0 0.083 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ORX71891.1 - 0.047 13.0 0.5 0.16 11.2 0.0 1.9 2 0 0 2 2 2 0 Septin DUF3873 PF12989.7 ORX71891.1 - 0.05 14.0 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) AAA_29 PF13555.6 ORX71891.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain LANC_like PF05147.13 ORX71891.1 - 0.061 11.9 0.3 0.1 11.2 0.2 1.5 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein TniB PF05621.11 ORX71891.1 - 0.082 12.3 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 ORX71891.1 - 0.12 12.1 0.8 1 9.1 0.1 2.5 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Methyltransf_16 PF10294.9 ORX71893.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Lysine methyltransferase ADH_zinc_N_2 PF13602.6 ORX71894.1 - 8.9e-17 62.4 0.0 1.9e-16 61.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ORX71894.1 - 3.2e-12 46.5 0.4 5.1e-12 45.9 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX71894.1 - 4.3e-07 29.8 0.0 1.3e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Sacchrp_dh_NADP PF03435.18 ORX71894.1 - 0.002 18.4 0.3 0.0053 17.0 0.1 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Urocanase PF01175.18 ORX71894.1 - 0.05 13.3 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Pkinase PF00069.25 ORX71895.1 - 1.3e-74 250.9 0.0 1.5e-74 250.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71895.1 - 2.1e-39 135.4 0.0 2.5e-39 135.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX71895.1 - 6.2e-06 25.7 0.1 9.8e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX71895.1 - 6.8e-06 25.6 0.0 8.7e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX71895.1 - 2.1e-05 23.5 0.0 3.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX71895.1 - 0.0011 18.9 0.1 0.048 13.6 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX71895.1 - 0.029 13.3 0.1 0.042 12.8 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain UFD1 PF03152.14 ORX71897.1 - 1e-67 227.0 0.0 1.2e-67 226.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GATA PF00320.27 ORX71898.1 - 3.5e-14 52.1 7.2 5.1e-14 51.6 7.2 1.3 1 0 0 1 1 1 1 GATA zinc finger ADD_ATRX PF17981.1 ORX71898.1 - 0.38 10.6 2.1 0.94 9.4 2.1 1.6 1 1 0 1 1 1 0 Cysteine Rich ADD domain ABC_membrane_2 PF06472.15 ORX71899.1 - 2.4e-11 43.6 0.5 0.00014 21.4 0.7 3.5 3 0 0 3 3 3 3 ABC transporter transmembrane region 2 SET PF00856.28 ORX71900.1 - 5.1e-10 40.0 3.9 5.5e-10 39.9 0.1 2.7 2 2 0 2 2 2 1 SET domain zf-MYND PF01753.18 ORX71900.1 - 0.00023 21.2 11.1 0.00023 21.2 11.1 3.0 2 2 0 2 2 2 1 MYND finger Syntaxin_2 PF14523.6 ORX71900.1 - 0.54 10.7 0.1 0.54 10.7 0.1 2.4 3 0 0 3 3 3 0 Syntaxin-like protein DALR_1 PF05746.15 ORX71901.1 - 5.4e-13 49.2 0.0 9.4e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain EccE PF11203.8 ORX71901.1 - 0.14 12.5 2.3 3.3 8.1 0.2 2.7 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE HSP70 PF00012.20 ORX71902.1 - 7.2e-248 823.7 6.1 1.5e-247 822.7 6.1 1.4 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX71902.1 - 9.8e-16 57.5 0.1 7.7e-15 54.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ORX71902.1 - 0.0012 18.7 0.0 0.0053 16.5 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 ORX71902.1 - 0.013 14.8 1.4 0.02 14.1 0.1 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase SAPIS-gp6 PF16722.5 ORX71902.1 - 0.032 14.6 1.8 0.11 13.0 1.8 1.8 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus DDR PF08841.10 ORX71902.1 - 0.079 11.9 0.1 0.84 8.6 0.1 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.11 ORX71902.1 - 0.1 11.8 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 StbA protein Peptidase_C78 PF07910.13 ORX71904.1 - 1.5e-45 155.3 0.0 1.9e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C78 Glu_synthase PF01645.17 ORX71905.1 - 3.3e-135 450.9 0.4 9.2e-135 449.5 0.4 1.8 1 1 0 1 1 1 1 Conserved region in glutamate synthase GATase_2 PF00310.21 ORX71905.1 - 1.6e-129 432.3 0.0 3.2e-127 424.8 0.0 3.0 1 1 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 ORX71905.1 - 7.3e-102 340.6 0.0 1.6e-101 339.5 0.0 1.6 2 0 0 2 2 1 1 Glutamate synthase central domain GXGXG PF01493.19 ORX71905.1 - 1.9e-66 223.3 0.7 3.7e-66 222.4 0.7 1.5 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 ORX71905.1 - 1.2e-18 67.0 0.2 2.7e-18 65.8 0.2 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 ORX71905.1 - 1.2e-18 67.4 0.1 7.5e-13 48.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX71905.1 - 3.3e-09 36.9 0.0 1.2e-08 35.0 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ORX71905.1 - 1.3e-07 31.3 0.0 2.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 ORX71905.1 - 5.6e-07 29.3 1.5 9.1e-07 28.6 0.3 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ORX71905.1 - 3.7e-06 27.4 0.1 1.6e-05 25.3 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX71905.1 - 1.6e-05 23.9 1.4 3.8e-05 22.6 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_2 PF00890.24 ORX71905.1 - 1.9e-05 23.9 0.5 6.2e-05 22.2 0.2 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 ORX71905.1 - 5.1e-05 22.7 0.2 9.3e-05 21.8 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX71905.1 - 5.6e-05 22.9 0.8 0.00071 19.3 0.3 2.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX71905.1 - 0.0013 18.0 0.2 0.0065 15.7 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 ORX71905.1 - 0.0019 17.5 0.0 0.0069 15.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GATase_6 PF13522.6 ORX71905.1 - 0.026 14.7 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 Glutamine amidotransferase domain NAD_binding_9 PF13454.6 ORX71905.1 - 0.076 13.0 0.1 0.27 11.2 0.1 2.0 2 0 0 2 2 1 0 FAD-NAD(P)-binding GIDA PF01134.22 ORX71905.1 - 0.078 12.0 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 ORX71905.1 - 0.13 12.2 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PG_binding_2 PF08823.11 ORX71905.1 - 0.35 11.2 1.0 3.8 7.9 0.5 2.8 3 0 0 3 3 3 0 Putative peptidoglycan binding domain KH_1 PF00013.29 ORX71906.1 - 8.1e-45 150.5 12.3 2.9e-17 62.2 0.8 4.2 3 1 0 3 3 3 3 KH domain KH_2 PF07650.17 ORX71906.1 - 1.3e-16 60.2 0.6 0.00033 20.4 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 ORX71906.1 - 3.6e-09 36.4 0.7 0.046 13.6 0.0 3.5 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 ORX71906.1 - 2.5e-05 24.2 0.0 0.18 11.8 0.0 2.6 2 0 0 2 2 2 2 KH-like RNA-binding domain KH_5 PF13184.6 ORX71906.1 - 0.0056 16.7 1.5 4.3 7.5 0.0 3.3 3 0 0 3 3 3 1 NusA-like KH domain dUTPase PF00692.19 ORX71906.1 - 0.027 14.2 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 dUTPase dCMP_cyt_deam_1 PF00383.23 ORX71907.1 - 4.5e-10 39.3 0.3 6e-10 38.9 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Inv-AAD PF18785.1 ORX71907.1 - 2.4e-07 30.7 3.4 1.7e-06 28.0 3.4 2.3 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase MafB19-deam PF14437.6 ORX71907.1 - 4.9e-07 29.6 0.2 6e-07 29.3 0.2 1.1 1 0 0 1 1 1 1 MafB19-like deaminase AAR2 PF05282.11 ORX71908.1 - 1.8e-81 274.3 0.0 2.2e-81 274.0 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein adh_short PF00106.25 ORX71910.1 - 2.6e-10 40.1 0.5 5.5e-10 39.0 0.5 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX71910.1 - 2.4e-06 27.3 0.2 1.8e-05 24.4 0.2 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PB1 PF00564.24 ORX71911.1 - 3.5e-06 26.9 0.0 1.2e-05 25.2 0.0 2.0 1 0 0 1 1 1 1 PB1 domain Phage_lysozyme PF00959.19 ORX71914.1 - 4.6e-14 52.8 0.0 8.5e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX71914.1 - 4.9e-05 23.5 0.2 0.00017 21.8 0.1 2.0 2 0 0 2 2 2 1 Bacterial SH3 domain Collagen PF01391.18 ORX71914.1 - 0.003 17.3 7.9 0.0053 16.5 7.9 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) AMP-binding_C PF13193.6 ORX71915.1 - 2.7e-20 73.1 0.5 3.8e-20 72.7 0.5 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1059 PF06348.11 ORX71915.1 - 0.011 16.0 0.4 0.011 16.0 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) GRP PF07172.11 ORX71916.1 - 0.35 11.6 9.9 21 5.9 8.1 2.3 2 0 0 2 2 2 0 Glycine rich protein family E3_binding PF02817.17 ORX71917.1 - 2.9e-09 37.1 0.0 8.5e-09 35.6 0.0 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 ORX71917.1 - 0.00011 22.0 0.2 0.00033 20.4 0.2 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Xan_ur_permease PF00860.20 ORX71918.1 - 6.9e-25 87.6 30.0 9.1e-24 83.9 30.0 2.3 1 1 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 ORX71918.1 - 0.012 16.0 5.2 0.012 16.0 5.2 3.1 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily Xan_ur_permease PF00860.20 ORX71919.1 - 1.3e-28 99.8 31.3 3.6e-26 91.8 31.9 2.9 2 1 0 2 2 2 1 Permease family DRIM PF07539.12 ORX71921.1 - 9.3e-110 367.8 11.6 1.8e-78 264.4 0.1 3.6 3 1 0 3 3 3 2 Down-regulated in metastasis HEAT PF02985.22 ORX71921.1 - 0.004 17.3 2.5 6.9 7.2 0.0 5.8 5 0 0 5 5 5 1 HEAT repeat DUF4253 PF14062.6 ORX71921.1 - 0.045 13.9 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) AMP-binding PF00501.28 ORX71922.1 - 1.6e-71 241.1 0.0 2.1e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX71922.1 - 2.9e-17 63.4 0.1 7.8e-17 62.0 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ORX71922.1 - 3.7e-14 52.4 0.1 6.7e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus EF-hand_4 PF12763.7 ORX71924.1 - 1.5e-36 124.5 0.0 1.2e-13 50.9 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ORX71924.1 - 7.3e-05 22.0 0.0 1.8 8.3 0.0 3.6 3 0 0 3 3 3 2 EF hand DUF812 PF05667.11 ORX71924.1 - 0.00086 18.3 15.6 0.0014 17.7 15.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) EF-hand_7 PF13499.6 ORX71924.1 - 0.0051 17.2 0.0 28 5.2 0.0 3.7 3 0 0 3 3 3 0 EF-hand domain pair Seryl_tRNA_N PF02403.22 ORX71924.1 - 0.44 10.8 25.1 1 9.7 5.5 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.9 ORX71924.1 - 0.56 10.2 27.4 1.7 8.7 19.7 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 ORX71924.1 - 0.77 8.0 30.0 1.1 7.5 30.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein zf-C4H2 PF10146.9 ORX71924.1 - 0.89 9.8 13.7 0.98 9.7 12.0 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein DUF4472 PF14739.6 ORX71924.1 - 1.3 9.8 26.0 2.7 8.8 4.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Peptidase_S46 PF10459.9 ORX71924.1 - 1.7 7.2 19.4 2.9 6.4 19.4 1.2 1 0 0 1 1 1 0 Peptidase S46 APG6_N PF17675.1 ORX71924.1 - 2 8.9 36.9 13 6.4 9.3 2.4 1 1 1 2 2 1 0 Apg6 coiled-coil region Lebercilin PF15619.6 ORX71924.1 - 2.6 7.7 32.3 0.13 11.9 23.1 2.7 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 ORX71924.1 - 2.9 6.7 29.7 6.2 5.6 29.3 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein HAP1_N PF04849.13 ORX71924.1 - 2.9 7.0 26.1 75 2.4 27.1 2.0 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DAGK_cat PF00781.24 ORX71927.1 - 5.2e-12 45.5 0.0 9.3e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.19 ORX71927.1 - 7.2e-10 39.4 0.0 1.2e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain ABC_tran_CTD PF16326.5 ORX71928.1 - 3.4 8.0 6.7 1.9 8.8 2.6 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain HMG_box PF00505.19 ORX71929.1 - 1.5e-13 51.0 0.3 2e-13 50.5 0.3 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX71929.1 - 1.7e-08 34.9 0.1 2.3e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 ORX71929.1 - 0.00014 21.7 0.3 0.00021 21.2 0.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box 5 Phage_lysozyme PF00959.19 ORX71930.1 - 4.7e-14 52.8 0.0 8.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX71930.1 - 4.5e-05 23.7 0.1 0.00015 22.0 0.1 2.0 2 0 0 2 2 2 1 Bacterial SH3 domain PsaN PF05479.11 ORX71931.1 - 0.069 13.3 0.7 0.079 13.2 0.7 1.0 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) DUF3432 PF11914.8 ORX71933.1 - 0.0026 18.0 0.9 0.26 11.6 0.4 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF3432) AMP-binding PF00501.28 ORX71934.1 - 1.2e-76 258.1 0.0 1.5e-76 257.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ORX71934.1 - 2.7e-18 65.6 0.1 6.9e-18 64.3 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ORX71934.1 - 1.3e-11 45.3 0.2 3.2e-11 44.0 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1059 PF06348.11 ORX71934.1 - 0.052 13.8 0.9 0.16 12.2 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) ArsA_HSP20 PF17886.1 ORX71935.1 - 0.0048 16.4 0.0 0.0099 15.4 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 ORX71935.1 - 0.0077 16.4 2.2 0.25 11.5 0.0 2.4 2 0 0 2 2 2 1 Hsp20/alpha crystallin family 4HBT_3 PF13622.6 ORX71937.1 - 1.3e-40 140.2 2.7 1.5e-40 140.0 2.7 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX71937.1 - 1.9e-16 60.1 0.0 8.6e-13 48.3 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 ORX71937.1 - 0.034 14.5 0.5 11 6.5 0.1 2.3 2 0 0 2 2 2 0 Thioesterase superfamily VPS9 PF02204.18 ORX71938.1 - 1.6e-33 115.0 0.1 3.6e-33 113.9 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 ORX71938.1 - 1.5e-06 28.4 0.4 0.00018 21.8 0.0 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF5601) CUE PF02845.16 ORX71938.1 - 7.9e-05 22.3 0.1 0.00017 21.2 0.1 1.6 1 0 0 1 1 1 1 CUE domain Fes1 PF08609.10 ORX71939.1 - 2e-16 60.7 1.5 4.5e-16 59.5 1.5 1.7 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.6 ORX71939.1 - 2.6e-06 27.7 0.6 7.9e-05 23.0 0.0 2.7 1 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ORX71939.1 - 3e-06 27.0 0.3 0.023 14.9 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ORX71939.1 - 0.0018 18.7 0.3 0.059 13.9 0.1 3.5 2 1 1 3 3 3 2 HEAT-like repeat Arm PF00514.23 ORX71939.1 - 0.017 15.2 0.2 0.43 10.7 0.0 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 ORX71939.1 - 0.021 14.8 0.1 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) NNMT_PNMT_TEMT PF01234.17 ORX71939.1 - 0.021 14.0 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family V-ATPase_H_C PF11698.8 ORX71939.1 - 0.14 12.3 0.0 0.39 10.8 0.0 1.6 1 1 1 2 2 2 0 V-ATPase subunit H DNA_pol_E_B PF04042.16 ORX71940.1 - 3.9e-37 127.7 0.1 5.3e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 ORX71940.1 - 8.1e-26 90.6 0.8 3.8e-24 85.2 0.8 2.3 1 1 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain MIR PF02815.19 ORX71941.1 - 4.2e-08 33.3 0.5 4.1e-06 26.8 0.3 2.1 1 1 1 2 2 2 2 MIR domain BRCT_2 PF16589.5 ORX71943.1 - 1.6e-11 44.5 0.0 0.0024 18.3 0.0 4.0 3 1 0 3 3 3 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ORX71943.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 ORX71943.1 - 0.0024 18.2 0.1 0.038 14.4 0.1 2.5 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Pkinase PF00069.25 ORX71944.1 - 1e-54 185.7 0.0 1.9e-54 184.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX71944.1 - 6.1e-22 78.1 0.0 1.2e-20 73.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX71944.1 - 0.00016 21.1 0.1 0.00035 20.0 0.1 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX71944.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Rieske PF00355.26 ORX71945.1 - 1.5e-11 44.1 0.0 2.7e-11 43.3 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ORX71945.1 - 9.5e-10 38.8 0.6 2e-09 37.8 0.6 1.5 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region tRNA-synt_1g PF09334.11 ORX71946.1 - 4.7e-55 186.9 0.7 4.2e-46 157.5 0.0 3.9 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX71946.1 - 7.8e-12 44.2 0.1 2e-10 39.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ORX71946.1 - 0.0066 15.8 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ORX71946.1 - 0.034 13.1 0.0 0.048 12.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (K) Acetyltransf_1 PF00583.25 ORX71947.1 - 0.0097 16.1 0.0 1.8 8.8 0.0 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) family p450 PF00067.22 ORX71948.1 - 2.3e-35 122.3 0.0 1.4e-31 109.8 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 Xan_ur_permease PF00860.20 ORX71950.1 - 3e-24 85.5 33.3 8e-23 80.8 33.3 2.1 1 1 0 1 1 1 1 Permease family PALP PF00291.25 ORX71951.1 - 1.2e-32 113.6 0.0 6.5e-31 107.8 0.0 2.2 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ORX71951.1 - 0.00072 20.0 0.0 0.0099 16.3 0.0 2.6 2 0 0 2 2 2 1 CBS domain PMT PF02366.18 ORX71952.1 - 3.5e-73 246.2 16.0 5.9e-73 245.5 16.0 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX71952.1 - 1.3e-50 171.8 18.0 3.7e-50 170.3 18.0 1.8 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX71952.1 - 1.4e-10 41.4 0.0 3.4e-10 40.1 0.0 1.6 1 1 1 2 2 2 1 MIR domain LSM14 PF12701.7 ORX71953.1 - 2.4e-23 82.0 0.2 4e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 ORX71953.1 - 1.2e-13 51.8 2.0 1.2e-13 51.8 2.0 2.1 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 ORX71953.1 - 1.5e-05 25.0 0.0 2.7e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain GRP PF07172.11 ORX71953.1 - 0.097 13.4 52.8 0.21 12.3 22.4 2.5 2 0 0 2 2 2 0 Glycine rich protein family Proteasome PF00227.26 ORX71954.1 - 8.3e-55 185.2 0.0 1.3e-54 184.5 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX71954.1 - 1.3e-14 53.5 0.2 3.3e-14 52.2 0.2 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CNPase PF05881.12 ORX71954.1 - 0.082 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) DnaJ-X PF14308.6 ORX71955.1 - 4.2e-46 157.0 4.8 4.2e-46 157.0 4.8 3.1 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ORX71955.1 - 3.9e-14 52.5 3.1 8.2e-13 48.3 3.1 2.8 1 1 0 1 1 1 1 DnaJ domain TMEM108 PF15759.5 ORX71955.1 - 0.07 12.1 1.7 0.14 11.2 1.7 1.4 1 0 0 1 1 1 0 TMEM108 family pP_pnuc_1 PF18165.1 ORX71955.1 - 0.75 9.7 5.9 0.36 10.7 0.2 2.6 3 0 0 3 3 3 0 Predicted pPIWI-associating nuclease Halogen_Hydrol PF10112.9 ORX71955.1 - 0.9 9.5 5.4 3.1 7.8 0.1 3.3 3 1 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ubiquitin PF00240.23 ORX71956.1 - 2.3e-34 117.0 0.9 4.2e-34 116.1 0.9 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 ORX71956.1 - 2.5e-28 98.0 1.5 6.4e-28 96.7 1.5 1.8 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 ORX71956.1 - 4.6e-16 58.4 1.0 8.4e-16 57.6 1.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX71956.1 - 1.9e-05 25.1 0.4 7.5e-05 23.1 0.2 2.0 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX71956.1 - 0.00054 20.0 0.4 0.0013 18.9 0.4 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ORX71956.1 - 0.0032 17.4 0.0 0.0069 16.3 0.0 1.6 1 1 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ORX71956.1 - 0.005 17.4 0.4 0.0072 16.9 0.4 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 ORX71956.1 - 0.0064 16.8 0.3 0.011 16.1 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX71956.1 - 0.033 14.2 1.2 5.7 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Plexin_cytopl PF08337.12 ORX71956.1 - 0.67 8.6 3.5 5 5.7 0.5 2.2 2 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain BOP1NT PF08145.12 ORX71957.1 - 8.2e-91 304.5 4.9 1.4e-90 303.8 4.9 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 ORX71957.1 - 4e-25 87.6 6.1 7e-09 36.2 0.1 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX71957.1 - 4.4e-05 23.7 0.2 0.054 13.8 0.1 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BUD22 PF09073.10 ORX71957.1 - 9.1 5.5 26.3 18 4.5 26.3 1.5 1 0 0 1 1 1 0 BUD22 zf-C2H2 PF00096.26 ORX71958.1 - 0.02 15.3 11.2 0.34 11.5 8.7 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX71958.1 - 6.4 7.9 13.6 3.4 8.8 10.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger MCM PF00493.23 ORX71961.1 - 3.5e-97 323.9 0.0 5.4e-97 323.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX71961.1 - 2e-19 69.7 0.6 4.4e-19 68.6 0.6 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX71961.1 - 1.1e-12 48.2 0.0 3.1e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX71961.1 - 1.1e-08 35.6 0.0 2.6e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX71961.1 - 8.8e-08 31.8 0.1 9.5e-06 25.1 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX71961.1 - 1.1e-05 25.5 0.0 4e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 ORX71961.1 - 0.00089 19.1 0.8 0.0026 17.5 0.8 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 ORX71961.1 - 0.03 14.2 0.1 0.15 11.9 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX71961.1 - 0.033 14.6 0.3 0.32 11.4 0.3 2.7 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX71961.1 - 0.18 11.9 0.0 0.56 10.3 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase HOOK PF05622.12 ORX71965.1 - 9.6e-21 73.6 79.6 1.1e-11 43.7 0.2 4.4 2 1 0 2 2 2 2 HOOK protein GAS PF13851.6 ORX71965.1 - 0.0021 17.4 76.2 0.027 13.8 13.9 4.9 2 1 3 5 5 5 3 Growth-arrest specific micro-tubule binding ATF7IP_BD PF16788.5 ORX71965.1 - 0.009 16.1 1.7 0.009 16.1 1.7 3.3 3 0 0 3 3 3 1 ATF-interacting protein binding domain HTH_23 PF13384.6 ORX71965.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.3 3 0 0 3 3 3 0 Homeodomain-like domain DUF1269 PF06897.12 ORX71965.1 - 0.4 11.0 3.2 0.85 9.9 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Golgin_A5 PF09787.9 ORX71965.1 - 2.3 7.6 79.9 0.041 13.3 12.3 4.7 1 1 3 4 4 4 0 Golgin subfamily A member 5 Spc7 PF08317.11 ORX71965.1 - 2.3 7.0 81.4 0.27 10.1 16.0 4.4 1 1 3 4 4 4 0 Spc7 kinetochore protein Pkinase_fungal PF17667.1 ORX71967.1 - 0.15 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase NAC PF01849.18 ORX71968.1 - 1.2e-21 76.4 0.1 2.9e-21 75.2 0.1 1.7 1 0 0 1 1 1 1 NAC domain ANAPC15 PF15243.6 ORX71968.1 - 0.013 15.8 0.6 0.026 14.9 0.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Mem_trans PF03547.18 ORX71968.1 - 7.1 4.9 5.9 10 4.4 1.8 2.0 2 0 0 2 2 2 0 Membrane transport protein DSHCT PF08148.12 ORX71969.1 - 1.4e-41 141.9 0.5 2.8e-41 140.9 0.5 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ORX71969.1 - 2.6e-12 46.9 0.0 5.3e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ski2_N PF17911.1 ORX71969.1 - 4.7e-12 45.9 0.1 4.5e-11 42.7 0.1 2.1 2 0 0 2 2 2 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 ORX71969.1 - 1e-08 35.5 0.0 2.6e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 rRNA-processing arch domain Helicase_C PF00271.31 ORX71969.1 - 8.4e-07 29.3 0.0 1.7e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX71969.1 - 0.0005 20.1 0.0 0.00086 19.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4764 PF15961.5 ORX71970.1 - 0.15 10.7 1.4 0.22 10.2 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) HIT PF01230.23 ORX71972.1 - 1.1e-17 64.6 0.5 2.3e-17 63.5 0.3 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 ORX71972.1 - 1.1e-05 25.8 0.2 1.8e-05 25.1 0.2 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX71972.1 - 0.01 15.7 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Got1 PF04178.12 ORX71973.1 - 1.9e-27 95.9 12.8 2.1e-27 95.8 12.8 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family TcpE PF12648.7 ORX71973.1 - 0.012 16.1 4.9 0.012 16.1 4.9 1.4 1 1 0 1 1 1 0 TcpE family FA_desaturase PF00487.24 ORX71973.1 - 0.94 9.3 3.9 0.97 9.2 3.9 1.1 1 0 0 1 1 1 0 Fatty acid desaturase PMT PF02366.18 ORX71974.1 - 1e-79 267.6 12.9 1e-79 267.6 12.9 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX71974.1 - 2.9e-55 187.0 6.8 2.9e-55 187.0 6.8 2.0 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX71974.1 - 1.2e-28 100.3 3.6 1.7e-28 99.7 3.6 1.2 1 0 0 1 1 1 1 MIR domain SchA_CurD PF04486.12 ORX71974.1 - 0.12 12.5 0.0 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 SchA/CurD like domain Mucin_bdg PF03272.13 ORX71974.1 - 0.19 11.8 0.8 0.5 10.4 0.7 1.7 1 1 1 2 2 2 0 Putative mucin or carbohydrate-binding module PMT_4TMC PF16192.5 ORX71975.1 - 1.1e-49 168.7 12.6 1.5e-49 168.3 12.6 1.2 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX71975.1 - 4.3e-11 43.0 0.2 1.3e-10 41.4 0.1 1.7 1 1 1 2 2 2 1 MIR domain PMT PF02366.18 ORX71976.1 - 3.9e-77 259.2 15.3 3.9e-77 259.2 15.3 2.2 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX71976.1 - 4.6e-47 160.2 12.9 4.6e-47 160.2 12.9 2.1 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX71976.1 - 3.4e-27 95.5 0.3 5.1e-27 94.9 0.3 1.2 1 0 0 1 1 1 1 MIR domain Thump_like PF18096.1 ORX71976.1 - 0.2 11.6 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 THUMP domain-like Aminotran_4 PF01063.19 ORX71977.1 - 1.4e-32 113.3 0.0 1.8e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Pho88 PF10032.9 ORX71979.1 - 1.1e-46 158.4 0.5 1.2e-46 158.2 0.5 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) TraQ PF09679.10 ORX71979.1 - 0.048 13.6 0.0 0.086 12.8 0.0 1.5 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Ge1_WD40 PF16529.5 ORX71980.1 - 2e-08 33.6 0.0 3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RRF PF01765.19 ORX71982.1 - 2.2e-47 161.0 4.6 2.2e-47 161.0 4.6 1.4 1 1 1 2 2 2 1 Ribosome recycling factor AHH PF14412.6 ORX71982.1 - 0.0064 16.6 0.0 0.083 13.0 0.0 2.2 1 1 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH GPW_gp25 PF04965.14 ORX71982.1 - 0.057 13.2 0.2 0.27 11.0 0.0 2.2 3 0 0 3 3 3 0 Gene 25-like lysozyme PUF PF00806.19 ORX71983.1 - 2.2e-31 105.8 0.3 1.3e-06 27.8 0.0 5.5 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat TFIIA PF03153.13 ORX71983.1 - 6.5 6.6 14.4 0.51 10.3 8.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 ORX71983.1 - 7.7 7.1 17.0 0.84 10.3 10.2 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_46 PF01374.18 ORX71984.1 - 1.8e-25 89.8 7.1 6.1e-24 84.8 1.9 2.8 1 1 1 2 2 2 2 Glycosyl hydrolase family 46 GalP_UDP_transf PF01087.22 ORX71986.1 - 4.5e-70 235.8 0.4 4.3e-67 226.1 0.0 2.9 3 0 0 3 3 3 2 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ORX71986.1 - 1.9e-55 187.2 0.2 3.4e-55 186.3 0.2 1.4 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 ORX71986.1 - 0.00085 20.0 0.4 0.066 14.0 1.6 2.6 2 1 0 2 2 2 1 HIT domain DUF4921 PF16268.5 ORX71986.1 - 0.00088 18.2 0.0 0.48 9.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) DcpS_C PF11969.8 ORX71986.1 - 0.0024 18.3 0.1 0.006 17.1 0.1 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding SNARE PF05739.19 ORX71987.1 - 5.5e-16 58.3 3.2 5.5e-16 58.3 3.2 1.8 2 0 0 2 2 2 1 SNARE domain DUF3675 PF12428.8 ORX71987.1 - 0.073 13.6 0.4 0.25 11.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3675) Pex14_N PF04695.13 ORX71988.1 - 0.056 14.1 6.8 0.067 13.9 6.8 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region G_path_suppress PF15991.5 ORX71988.1 - 0.14 12.3 3.8 0.15 12.2 3.8 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor Period_C PF12114.8 ORX71988.1 - 0.26 10.8 3.9 0.3 10.6 3.9 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region RRM_1 PF00076.22 ORX71989.1 - 8.6e-07 28.7 0.0 1.2e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) R3H PF01424.22 ORX71990.1 - 2.9e-05 24.0 0.0 2.9e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 R3H domain SUZ-C PF12901.7 ORX71990.1 - 0.00061 19.7 0.6 0.0034 17.3 0.6 2.4 1 0 0 1 1 1 1 SUZ-C motif Spt20 PF12090.8 ORX71990.1 - 2.3 7.8 12.7 0.3 10.7 5.6 2.0 2 0 0 2 2 2 0 Spt20 family RNA_pol_Rpc82 PF05645.13 ORX71991.1 - 1.1e-16 61.4 0.9 2.5e-15 56.9 0.9 2.1 1 1 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 ORX71991.1 - 2.2e-15 56.5 0.4 1.2e-13 50.9 0.1 3.1 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 helix-turn-helix domain Glyco_hydro_46 PF01374.18 ORX71992.1 - 1.9e-38 132.2 3.6 7.9e-38 130.2 3.6 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 BT1 PF03092.16 ORX71993.1 - 0.061 11.5 0.0 0.11 10.7 0.0 1.3 1 0 0 1 1 1 0 BT1 family FAM76 PF16046.5 ORX71993.1 - 0.4 10.0 4.9 2 7.7 0.0 2.2 2 0 0 2 2 2 0 FAM76 protein PRP38_assoc PF12871.7 ORX71993.1 - 1 10.0 35.3 0.21 12.2 26.4 2.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFIIA PF03153.13 ORX71993.1 - 2.2 8.2 10.2 3.3 7.6 10.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DEAD PF00270.29 ORX71994.1 - 9.9e-46 155.7 0.6 1.2e-45 155.4 0.6 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX71994.1 - 9.9e-07 28.9 0.0 1.1e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ORX71994.1 - 3.1e-05 23.8 0.1 4.1e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX71994.1 - 0.0017 18.7 0.5 0.0022 18.3 0.5 1.4 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 ORX71994.1 - 0.0098 15.9 0.1 0.033 14.2 0.1 2.0 1 1 0 1 1 1 1 Flavivirus DEAD domain UvrD-helicase PF00580.21 ORX71994.1 - 0.033 13.7 0.3 0.046 13.2 0.3 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain CMS1 PF14617.6 ORX71994.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 ORX71994.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 ORX71994.1 - 0.2 12.0 0.7 1.5 9.1 0.7 2.2 1 1 0 1 1 1 0 AAA domain UTP25 PF06862.12 ORX71994.1 - 0.22 10.3 0.2 0.63 8.8 0.1 1.7 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MFS_1 PF07690.16 ORX71995.1 - 8e-36 123.7 44.4 8.7e-29 100.5 28.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX71995.1 - 9.1e-35 120.4 20.4 5.4e-33 114.5 20.4 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter Nodulin-like PF06813.13 ORX71995.1 - 0.0059 16.1 0.2 0.32 10.4 0.0 2.5 1 1 0 2 2 2 1 Nodulin-like Not1 PF04054.15 ORX71996.1 - 4.8e-107 358.1 0.0 1.2e-106 356.7 0.0 1.7 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 ORX71996.1 - 1.9e-87 292.3 0.1 5.2e-87 290.9 0.1 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 ORX71996.1 - 6.8e-34 116.9 1.0 3.5e-33 114.6 0.7 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 ORX71996.1 - 3.1e-32 111.3 0.0 3.1e-32 111.3 0.0 2.4 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 ORX71996.1 - 6.9e-12 45.7 1.7 6.9e-12 45.7 1.7 2.3 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CobT PF06213.12 ORX71996.1 - 0.13 11.7 3.7 0.89 8.9 3.4 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TFIIA PF03153.13 ORX71996.1 - 0.96 9.4 20.5 1.7 8.5 20.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 ORX71996.1 - 9.6 6.8 17.9 25 5.5 17.9 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BORCS8 PF10167.9 ORX71997.1 - 0.0033 17.3 0.0 0.0047 16.8 0.0 1.3 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 Exo_endo_phos PF03372.23 ORX71998.1 - 1.2e-16 61.0 0.1 2e-16 60.2 0.1 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_transf_15 PF01793.16 ORX71999.1 - 2.5e-77 260.3 3.3 3e-75 253.5 3.3 2.3 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PDCD2_C PF04194.13 ORX71999.1 - 4.7e-34 118.0 0.2 1.5e-31 109.8 0.0 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain Mito_carr PF00153.27 ORX72000.1 - 3e-67 222.6 6.2 2.7e-24 84.9 0.7 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-C3HC4_3 PF13920.6 ORX72001.1 - 4.5e-07 29.6 4.3 4.5e-07 29.6 4.3 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX72001.1 - 0.00061 19.6 6.2 0.00061 19.6 6.2 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX72001.1 - 0.014 15.2 5.9 0.014 15.2 5.9 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) MutS_V PF00488.21 ORX72002.1 - 9.9e-18 64.8 0.1 1.2e-13 51.5 0.1 2.6 1 1 1 2 2 2 2 MutS domain V MutS_III PF05192.18 ORX72002.1 - 1.4e-06 28.7 0.3 2.2e-06 28.0 0.3 1.2 1 0 0 1 1 1 1 MutS domain III AAA_23 PF13476.6 ORX72002.1 - 0.011 16.3 0.0 0.04 14.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ORX72002.1 - 0.027 14.3 0.1 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX72002.1 - 0.042 13.6 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_15 PF13175.6 ORX72002.1 - 0.075 12.7 0.0 0.22 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 ORX72002.1 - 0.1 13.0 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain SeqA_N PF17206.3 ORX72002.1 - 0.13 11.6 0.1 0.33 10.3 0.1 1.7 1 0 0 1 1 1 0 SeqA protein N-terminal domain HD PF01966.22 ORX72003.1 - 4.2e-10 39.9 0.0 1.2e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 HD domain Glyco_transf_34 PF05637.12 ORX72003.1 - 0.01 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family Sec62 PF03839.16 ORX72004.1 - 6.1e-43 146.9 10.2 6.7e-43 146.7 10.2 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 TEA PF01285.18 ORX72005.1 - 1e-12 47.9 0.2 2.3e-12 46.8 0.2 1.6 1 0 0 1 1 1 1 TEA/ATTS domain HEAT PF02985.22 ORX72007.1 - 2.9e-05 24.0 0.2 1.3 9.5 0.0 3.3 3 0 0 3 3 3 2 HEAT repeat CLASP_N PF12348.8 ORX72007.1 - 0.00036 20.2 1.0 0.00045 19.8 0.2 1.5 2 0 0 2 2 2 1 CLASP N terminal HEAT_2 PF13646.6 ORX72007.1 - 0.0038 17.6 0.1 0.007 16.7 0.1 1.4 1 0 0 1 1 1 1 HEAT repeats CHASE6_C PF17150.4 ORX72007.1 - 0.054 14.2 0.1 0.091 13.4 0.1 1.3 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain CLASP_N PF12348.8 ORX72008.1 - 5.7e-45 153.6 0.1 7.6e-45 153.2 0.1 1.2 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 ORX72010.1 - 2.6e-20 70.8 7.0 0.00048 20.1 0.1 9.8 10 0 0 10 10 9 4 HEAT repeat HEAT_EZ PF13513.6 ORX72010.1 - 3.6e-17 62.5 9.1 4.1e-08 33.6 0.0 7.8 7 1 0 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.6 ORX72010.1 - 6.4e-13 48.9 1.7 4.9e-05 23.7 0.0 5.5 3 2 1 4 4 4 3 HEAT repeats IBN_N PF03810.19 ORX72010.1 - 3e-07 30.3 5.2 1.1e-05 25.3 0.1 4.0 5 0 0 5 5 4 1 Importin-beta N-terminal domain Arm PF00514.23 ORX72010.1 - 3.4e-07 30.1 5.6 0.21 11.7 0.1 6.3 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 ORX72010.1 - 3.5e-06 26.4 0.2 0.19 10.8 0.0 3.5 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 ORX72010.1 - 1.6e-05 25.4 0.2 0.013 16.1 0.1 4.3 4 2 0 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX72010.1 - 4.1e-05 23.7 0.1 0.1 12.6 0.0 3.7 2 2 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ORX72010.1 - 0.0028 16.3 5.3 1.1 7.7 3.5 3.0 3 1 0 3 3 3 2 Adaptin N terminal region MMS19_N PF14500.6 ORX72010.1 - 0.0029 17.2 1.9 2.5 7.6 0.0 3.5 3 2 2 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II TIP120 PF08623.10 ORX72010.1 - 0.022 14.6 0.2 1.1 9.0 0.0 3.4 2 1 1 3 3 3 0 TATA-binding protein interacting (TIP20) DUF3347 PF11827.8 ORX72010.1 - 0.087 13.0 0.6 0.18 12.0 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) ALF PF03752.13 ORX72010.1 - 0.15 12.1 2.2 0.58 10.2 0.7 2.6 2 0 0 2 2 2 0 Short repeats of unknown function HEAT_PBS PF03130.16 ORX72010.1 - 0.96 10.3 7.8 2.4e+02 2.9 0.1 6.6 8 0 0 8 8 5 0 PBS lyase HEAT-like repeat Pan3_PK PF18101.1 ORX72011.1 - 9.3e-59 197.3 0.0 1.6e-58 196.6 0.0 1.4 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 ORX72011.1 - 2e-07 30.7 0.0 2.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX72011.1 - 6.2e-05 22.4 0.0 9.1e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FAT PF02259.23 ORX72012.1 - 2.8e-59 201.1 0.3 6.5e-59 199.9 0.3 1.7 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ORX72012.1 - 1.2e-06 28.6 0.0 3.8e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ORX72012.1 - 7.6e-06 25.6 0.3 2.7e-05 23.9 0.3 2.0 1 0 0 1 1 1 1 FATC domain NUC194 PF08163.12 ORX72012.1 - 0.024 13.6 2.4 0.035 13.0 0.2 2.4 3 0 0 3 3 3 0 NUC194 domain TPR_2 PF07719.17 ORX72012.1 - 0.13 12.4 1.9 4.7 7.6 1.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4404 PF14357.6 ORX72012.1 - 0.21 12.2 1.9 2 9.1 0.8 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) MMS19_N PF14500.6 ORX72012.1 - 0.31 10.6 8.9 20 4.7 0.0 5.9 5 0 0 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF3619 PF12279.8 ORX72012.1 - 5.5 7.3 7.6 0.46 10.8 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3619) Methyltransf_4 PF02390.17 ORX72013.1 - 3e-41 140.7 0.0 2.2e-28 98.9 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase MTS PF05175.14 ORX72013.1 - 0.00019 21.0 0.0 0.1 12.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX72013.1 - 0.00051 20.7 0.0 0.0078 16.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX72013.1 - 0.0064 17.1 0.0 0.6 10.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX72013.1 - 0.016 15.9 0.0 0.055 14.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 ORX72013.1 - 0.016 15.0 0.0 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain DOT1 PF08123.13 ORX72013.1 - 0.073 12.6 0.0 0.39 10.2 0.0 1.9 2 0 0 2 2 2 0 Histone methylation protein DOT1 Ureidogly_lyase PF04115.12 ORX72015.1 - 6.6e-48 162.9 0.0 7.9e-48 162.7 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase MRG PF05712.13 ORX72016.1 - 5.2e-55 185.8 0.6 7.8e-55 185.3 0.6 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 ORX72016.1 - 3.7e-09 36.3 0.0 7.4e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PDT PF00800.18 ORX72017.1 - 4.3e-45 153.8 0.6 1.9e-44 151.7 0.6 1.9 1 1 0 1 1 1 1 Prephenate dehydratase CM_2 PF01817.21 ORX72017.1 - 2.7e-11 43.7 0.0 8.1e-11 42.1 0.0 1.8 1 1 0 1 1 1 1 Chorismate mutase type II UPF0172 PF03665.13 ORX72018.1 - 2.1e-46 158.4 0.2 2.4e-46 158.2 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Tfb2_C PF18307.1 ORX72020.1 - 0.052 14.0 0.0 0.069 13.6 0.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 (p52) C-terminal domain DUF3888 PF13027.6 ORX72020.1 - 0.1 13.1 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) Adaptin_N PF01602.20 ORX72022.1 - 1.6e-93 314.1 0.0 2e-93 313.7 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX72022.1 - 2.8e-13 50.2 0.0 6.4e-12 45.8 0.0 2.9 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX72022.1 - 0.041 14.1 11.4 9 6.9 0.1 5.9 5 1 1 6 6 6 0 HEAT repeat Phage_TAC_11 PF11836.8 ORX72022.1 - 0.12 12.5 4.1 0.32 11.1 2.2 2.7 3 0 0 3 3 3 0 Phage tail tube protein, GTA-gp10 Allantoicase PF03561.15 ORX72023.1 - 1.7e-87 290.8 0.0 7.2e-44 149.3 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat PH PF00169.29 ORX72025.1 - 3.6e-06 27.4 0.0 0.016 15.7 0.0 2.5 2 0 0 2 2 2 2 PH domain Ank_5 PF13857.6 ORX72025.1 - 0.0034 17.7 0.0 0.0086 16.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ORX72025.1 - 0.099 13.1 0.2 0.26 11.8 0.2 1.7 1 0 0 1 1 1 0 Ankyrin repeat ABC_tran PF00005.27 ORX72026.1 - 9.7e-43 146.0 1.3 2.9e-23 82.9 0.0 4.0 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX72026.1 - 3.6e-16 59.3 1.3 1.8e-05 24.3 0.0 3.8 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX72026.1 - 1.3e-13 51.4 9.6 0.00033 20.5 0.0 4.9 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX72026.1 - 1.3e-08 34.9 1.1 0.0015 18.5 0.0 2.6 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX72026.1 - 1.6e-08 34.6 0.0 0.0063 16.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX72026.1 - 1.1e-06 28.3 0.1 0.021 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 ORX72026.1 - 1.2e-05 25.7 0.2 0.064 13.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 ORX72026.1 - 2.1e-05 23.8 0.0 0.082 12.1 0.0 2.5 2 1 0 2 2 2 2 NB-ARC domain RNA_helicase PF00910.22 ORX72026.1 - 4.9e-05 23.7 0.0 0.12 12.7 0.0 3.0 3 0 0 3 3 2 1 RNA helicase AAA_16 PF13191.6 ORX72026.1 - 9.4e-05 22.9 2.7 0.047 14.1 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ORX72026.1 - 0.00015 22.3 5.5 0.042 14.4 0.4 2.9 3 1 0 3 3 2 2 AAA domain AAA PF00004.29 ORX72026.1 - 0.00026 21.4 1.1 3 8.3 0.4 4.2 3 2 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ORX72026.1 - 0.00037 20.5 0.1 0.17 11.8 0.0 2.8 3 0 0 3 3 2 1 NACHT domain Dynamin_N PF00350.23 ORX72026.1 - 0.00048 20.2 0.0 0.11 12.6 0.0 2.6 2 1 0 2 2 2 1 Dynamin family AAA_14 PF13173.6 ORX72026.1 - 0.00066 19.7 0.1 5.1 7.1 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_15 PF13175.6 ORX72026.1 - 0.0015 18.3 0.1 0.16 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 ORX72026.1 - 0.0019 17.2 0.2 0.47 9.4 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 ORX72026.1 - 0.0024 17.5 0.1 0.045 13.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 ORX72026.1 - 0.0027 17.9 4.5 0.0083 16.2 0.1 2.9 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_22 PF13401.6 ORX72026.1 - 0.0055 17.0 3.3 1.2 9.4 0.0 3.8 3 1 0 3 3 3 1 AAA domain DUF503 PF04456.12 ORX72026.1 - 0.0067 16.3 0.5 1 9.3 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF503) AAA_18 PF13238.6 ORX72026.1 - 0.0078 16.8 0.3 11 6.6 0.0 3.2 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ORX72026.1 - 0.0082 15.9 0.3 0.88 9.3 0.0 3.3 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 ORX72026.1 - 0.014 15.1 0.2 1.1 8.9 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein ATPase_2 PF01637.18 ORX72026.1 - 0.028 14.3 0.0 13 5.6 0.0 3.0 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ORX72026.1 - 0.042 13.4 0.0 10 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Roc PF08477.13 ORX72026.1 - 0.044 14.0 0.1 10 6.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ORX72026.1 - 0.056 12.7 0.1 9.9 5.3 0.0 2.2 2 0 0 2 2 2 0 Septin Bac_DnaA PF00308.18 ORX72026.1 - 0.094 12.5 0.1 0.34 10.7 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein G-alpha PF00503.20 ORX72026.1 - 0.13 11.4 0.0 14 4.7 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 ORX72026.1 - 0.19 11.3 4.3 5 6.6 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B NTPase_1 PF03266.15 ORX72026.1 - 0.19 11.6 4.6 14 5.5 0.0 4.1 5 0 0 5 5 4 0 NTPase DUF1367 PF07105.11 ORX72026.1 - 0.21 11.2 2.6 3.2 7.4 0.5 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1367) AAA_33 PF13671.6 ORX72026.1 - 0.24 11.6 6.0 5.6 7.1 0.1 3.7 2 2 0 2 2 2 0 AAA domain ABC_tran_Xtn PF12848.7 ORX72026.1 - 0.4 10.7 8.4 1.4 9.0 3.4 3.1 2 1 0 2 2 2 0 ABC transporter Ribosomal_S14 PF00253.21 ORX72027.1 - 1.4e-14 53.5 3.9 1.6e-14 53.4 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e AAA-ATPase_like PF09820.9 ORX72027.1 - 0.035 13.5 0.2 0.044 13.2 0.2 1.1 1 0 0 1 1 1 0 Predicted AAA-ATPase Peptidase_M41 PF01434.18 ORX72028.1 - 1.8e-59 200.8 0.5 3.2e-59 200.0 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX72028.1 - 6.9e-35 120.4 0.0 1.1e-20 74.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Intein_splicing PF14890.6 ORX72028.1 - 2.2e-10 40.6 0.0 4.9e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Intein splicing domain AAA_16 PF13191.6 ORX72028.1 - 4.8e-08 33.6 0.2 0.003 18.0 0.0 3.7 3 0 0 3 3 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 ORX72028.1 - 4.1e-07 29.7 0.0 1.1e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 ORX72028.1 - 9e-05 21.8 0.0 0.00017 20.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 ORX72028.1 - 0.00024 21.1 0.0 0.0082 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX72028.1 - 0.00064 19.5 0.0 0.0043 16.8 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX72028.1 - 0.0013 19.0 0.6 0.074 13.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ORX72028.1 - 0.023 15.2 0.3 0.13 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX72028.1 - 0.025 14.3 0.1 0.063 13.0 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 ORX72028.1 - 0.07 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX72028.1 - 0.085 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX72028.1 - 0.1 12.1 0.0 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain LAGLIDADG_3 PF14528.6 ORX72028.1 - 0.13 12.6 0.0 0.38 11.1 0.0 1.9 1 0 0 1 1 1 0 LAGLIDADG-like domain ATPase PF06745.13 ORX72028.1 - 0.15 11.4 0.2 0.67 9.3 0.1 1.9 2 0 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 ORX72028.1 - 0.15 11.4 3.2 0.1 12.0 0.2 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ORX72028.1 - 0.16 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fasciclin PF02469.22 ORX72029.1 - 2.4e-07 31.0 0.0 3.7e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain OrsD PF12013.8 ORX72031.1 - 8.1e-06 26.3 1.2 1.2e-05 25.7 1.2 1.2 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D Spermine_synth PF01564.17 ORX72031.1 - 0.076 12.4 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Syntaxin PF00804.25 ORX72032.1 - 4.3e-16 59.2 9.9 5.8e-16 58.8 9.9 1.1 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.6 ORX72032.1 - 0.0006 20.2 7.9 0.0036 17.7 3.0 2.2 2 0 0 2 2 2 1 Syntaxin-like protein UxuA PF03786.13 ORX72032.1 - 0.0038 16.1 0.2 0.0048 15.8 0.2 1.2 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) DUF948 PF06103.11 ORX72032.1 - 0.018 15.3 2.7 0.03 14.6 1.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SNARE PF05739.19 ORX72032.1 - 0.039 14.0 1.6 0.18 11.8 0.2 2.7 2 0 0 2 2 2 0 SNARE domain DUF16 PF01519.16 ORX72032.1 - 0.091 13.3 5.7 0.29 11.6 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 SAB PF04382.13 ORX72032.1 - 0.27 11.3 0.3 0.27 11.3 0.3 2.1 2 0 0 2 2 2 0 SAB domain Laminin_II PF06009.12 ORX72032.1 - 0.36 10.9 4.8 0.19 11.8 0.6 2.3 2 1 0 2 2 2 0 Laminin Domain II Rab_bind PF16704.5 ORX72032.1 - 0.77 9.8 0.0 0.77 9.8 0.0 2.8 3 1 1 4 4 4 0 Rab binding domain DUF4795 PF16043.5 ORX72032.1 - 0.88 9.1 5.1 1.3 8.6 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) Fib_alpha PF08702.10 ORX72032.1 - 3.3 7.9 9.6 6.3 7.0 1.4 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 ORX72032.1 - 3.8 8.1 6.5 7.2 7.2 3.3 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Bromo_TP PF07524.13 ORX72033.1 - 4.4e-08 33.0 0.1 1.6e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 Bromodomain associated TFIIA PF03153.13 ORX72033.1 - 0.12 12.3 10.9 0.0064 16.5 5.4 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RL10P_insert PF17777.1 ORX72034.1 - 2.2e-23 82.0 0.0 3.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 ORX72034.1 - 7.4e-21 74.2 0.7 1.1e-20 73.6 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 DHC_N2 PF08393.13 ORX72034.1 - 0.04 13.0 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 LSM14 PF12701.7 ORX72034.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Scd6-like Sm domain Mur_ligase_M PF08245.12 ORX72035.1 - 4.1e-09 36.7 0.0 2.7e-08 34.0 0.0 2.1 1 1 0 1 1 1 1 Mur ligase middle domain DWNN PF08783.11 ORX72036.1 - 2.3e-27 95.0 0.3 4.1e-27 94.3 0.3 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 ORX72036.1 - 3.6e-09 36.3 8.5 1.2e-08 34.6 8.5 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 ORX72036.1 - 2.2e-05 24.2 7.8 2.2e-05 24.2 7.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX72036.1 - 2.7e-05 24.2 13.6 5e-05 23.4 13.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ORX72036.1 - 0.00043 20.6 11.0 0.00093 19.5 11.0 1.6 1 0 0 1 1 1 1 Ring finger domain U-box PF04564.15 ORX72036.1 - 0.00047 20.3 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 ORX72036.1 - 0.00074 19.3 11.9 0.0015 18.3 11.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ORX72036.1 - 0.0015 18.4 4.3 0.0029 17.4 4.3 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-CCHC PF00098.23 ORX72036.1 - 0.002 18.1 2.9 0.0069 16.4 2.9 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ORX72036.1 - 0.0028 17.6 0.1 0.0028 17.6 0.1 2.1 2 0 0 2 2 1 1 Zinc knuckle zf-RING_5 PF14634.6 ORX72036.1 - 0.012 15.6 10.2 0.012 15.6 10.2 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX72036.1 - 0.013 15.5 9.7 0.027 14.5 9.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX72036.1 - 0.02 14.8 11.6 0.037 13.9 11.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_4 PF13717.6 ORX72036.1 - 0.25 11.3 4.2 0.97 9.4 0.1 2.9 3 0 0 3 3 2 0 zinc-ribbon domain RCC1 PF00415.18 ORX72037.1 - 5.6e-39 132.5 19.3 2.6e-10 40.7 0.2 7.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX72037.1 - 1.2e-29 101.4 39.6 8.1e-09 35.1 1.3 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Ist1 PF03398.14 ORX72038.1 - 3e-58 196.4 2.1 3.3e-58 196.2 2.1 1.0 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Abhydrolase_2 PF02230.16 ORX72039.1 - 5.8e-62 209.3 0.1 7.1e-62 209.0 0.1 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ORX72039.1 - 3e-07 29.9 1.4 0.0049 16.2 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX72039.1 - 5.6e-07 30.4 0.0 6.7e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX72039.1 - 9.7e-06 25.4 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 ORX72039.1 - 1.3e-05 24.8 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 ORX72039.1 - 0.00016 21.4 0.0 0.0005 19.8 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 ORX72039.1 - 0.00024 20.6 0.1 0.044 13.3 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ORX72039.1 - 0.00034 20.5 0.4 0.031 14.1 0.0 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 ORX72039.1 - 0.001 18.8 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 ORX72039.1 - 0.15 10.7 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.8 ORX72039.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Vac7 PF12751.7 ORX72041.1 - 2.7e-15 56.7 6.5 5.6e-14 52.4 1.6 2.9 2 1 0 2 2 2 1 Vacuolar segregation subunit 7 Roughex PF06020.11 ORX72041.1 - 0.8 8.7 3.8 1.5 7.8 3.8 1.4 1 0 0 1 1 1 0 Drosophila roughex protein bZIP_1 PF00170.21 ORX72042.1 - 3e-11 43.2 8.9 4.2e-11 42.8 8.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX72042.1 - 2.2e-06 27.6 10.4 3.7e-06 26.9 10.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX72042.1 - 0.017 15.6 4.1 0.028 14.9 4.1 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Aldose_epim PF01263.20 ORX72044.1 - 1.7e-65 221.3 0.1 2e-65 221.1 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Hydrolase PF00702.26 ORX72045.1 - 1.3e-12 48.5 0.1 2.9e-12 47.3 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX72045.1 - 5.5e-06 26.6 0.0 6.7e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX72045.1 - 4.4e-05 23.4 0.0 9.1e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like DUF1248 PF06852.12 ORX72045.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1248) B56 PF01603.20 ORX72045.1 - 0.16 10.9 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) LAMTOR5 PF16672.5 ORX72046.1 - 1.5e-12 47.3 0.0 1.7e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Robl_LC7 PF03259.17 ORX72046.1 - 0.055 13.2 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Roadblock/LC7 domain Zip PF02535.22 ORX72047.1 - 9e-58 196.1 18.6 5.1e-41 141.0 10.0 2.3 1 1 1 2 2 2 2 ZIP Zinc transporter Herpes_LMP1 PF05297.11 ORX72047.1 - 0.022 14.0 2.9 1.2 8.3 0.1 2.2 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Histone PF00125.24 ORX72048.1 - 5.5e-17 62.4 0.0 8.7e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ORX72048.1 - 1.2e-09 37.8 0.1 2e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ORX72048.1 - 0.00028 21.1 0.0 0.00039 20.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone K_channel_TID PF07941.11 ORX72048.1 - 3.4 8.2 7.2 5.2 7.6 3.7 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain EF-hand_7 PF13499.6 ORX72049.1 - 4.5e-17 62.3 0.3 3.9e-09 36.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ORX72049.1 - 5.7e-16 58.1 0.1 9e-09 35.1 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX72049.1 - 3.7e-12 44.9 1.4 0.00065 19.1 0.1 4.1 5 0 0 5 5 5 3 EF hand EF-hand_9 PF14658.6 ORX72049.1 - 4.5e-08 33.3 0.0 7.9e-05 22.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 ORX72049.1 - 5.8e-08 32.0 0.3 0.61 10.2 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_4 PF12763.7 ORX72049.1 - 0.093 12.7 0.1 0.55 10.2 0.0 1.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Hydrolase PF00702.26 ORX72050.1 - 1.2e-08 35.5 0.0 2.6e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX72050.1 - 4.3e-06 26.9 0.0 5e-06 26.7 0.0 1.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX72050.1 - 4.8e-06 26.5 0.0 9.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 ORX72050.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase Paramyxo_ncap PF00973.19 ORX72051.1 - 0.055 12.4 4.4 0.073 12.0 4.4 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Med19 PF10278.9 ORX72051.1 - 0.82 9.6 7.3 3.5 7.5 3.7 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 DUF1744 PF08490.12 ORX72052.1 - 1.2e-96 323.8 0.0 2.1e-96 322.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 ORX72052.1 - 1e-71 241.9 0.0 1.5e-71 241.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 ORX72052.1 - 1.1e-09 38.3 0.3 3.7e-09 36.6 0.3 1.8 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B PF00136.21 ORX72052.1 - 4.5e-07 28.9 0.5 4.3e-06 25.7 0.0 2.5 2 1 0 2 2 2 1 DNA polymerase family B RNase_H_2 PF13482.6 ORX72052.1 - 1e-06 28.9 0.0 4.5e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 RNase_H superfamily GCV_H PF01597.19 ORX72052.1 - 0.0026 17.6 0.0 0.015 15.2 0.0 2.3 3 0 0 3 3 3 1 Glycine cleavage H-protein UNC-50 PF05216.13 ORX72053.1 - 1.8e-73 246.8 19.8 2.4e-73 246.4 19.8 1.1 1 0 0 1 1 1 1 UNC-50 family YuiB PF14068.6 ORX72053.1 - 8.6 7.0 11.8 1 10.0 5.8 2.1 2 1 0 2 2 2 0 Putative membrane protein DSBA PF01323.20 ORX72054.1 - 5.7e-11 42.5 0.1 6.8e-05 22.7 0.0 2.3 2 1 0 2 2 2 2 DSBA-like thioredoxin domain Synaptobrevin PF00957.21 ORX72055.1 - 9.7e-31 105.4 1.7 1.8e-30 104.5 1.7 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ORX72055.1 - 1.7e-24 85.7 0.1 2.9e-24 84.9 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain S1 PF00575.23 ORX72055.1 - 0.032 14.6 0.1 0.055 13.8 0.1 1.4 1 0 0 1 1 1 0 S1 RNA binding domain MSC PF09402.10 ORX72055.1 - 0.04 13.4 0.2 0.052 13.0 0.2 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain HEAT_2 PF13646.6 ORX72057.1 - 1.9e-07 31.4 12.0 7.5e-07 29.4 0.9 4.7 4 2 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ORX72057.1 - 7.4e-05 22.8 0.2 0.14 12.2 0.0 4.0 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX72057.1 - 0.00032 20.7 8.2 0.028 14.7 0.1 5.8 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 ORX72057.1 - 0.0013 19.2 2.6 0.04 14.4 0.0 4.4 4 0 0 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 ORX72057.1 - 0.02 13.5 0.0 0.47 8.9 0.0 2.6 2 0 0 2 2 2 0 Adaptin N terminal region CLASP_N PF12348.8 ORX72057.1 - 0.031 13.8 1.4 0.13 11.8 0.0 2.8 3 1 0 3 3 3 0 CLASP N terminal NARP1 PF12569.8 ORX72058.1 - 5.6e-142 474.3 15.3 1.1e-127 427.2 9.2 3.4 3 1 1 4 4 4 3 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 ORX72058.1 - 4.2e-16 59.3 0.2 0.0075 16.9 0.1 6.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX72058.1 - 1.4e-15 57.5 7.8 0.00075 20.0 0.0 6.6 7 1 1 8 8 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72058.1 - 2.6e-15 55.8 3.1 0.23 12.4 0.1 9.3 8 2 3 11 11 9 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX72058.1 - 3.2e-13 48.7 3.8 0.37 11.0 0.1 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX72058.1 - 3.2e-09 36.8 4.2 0.12 12.5 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX72058.1 - 1.5e-08 34.5 3.1 11 6.7 0.0 8.3 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX72058.1 - 1.9e-08 33.9 1.3 0.25 11.7 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX72058.1 - 6.6e-06 26.3 2.7 0.43 10.8 0.0 5.0 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ORX72058.1 - 1e-05 25.8 7.8 0.47 11.2 0.1 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX72058.1 - 0.0011 18.6 9.6 8.9 6.3 0.0 6.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX72058.1 - 0.0028 17.6 3.6 3.7 7.8 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX72058.1 - 0.0055 17.0 6.9 10 6.5 0.1 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat End3 PF12761.7 ORX72058.1 - 0.018 15.2 0.2 0.067 13.4 0.2 1.9 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 TPR_11 PF13414.6 ORX72058.1 - 0.03 14.0 7.9 6.4 6.5 0.1 6.0 6 0 0 6 6 6 0 TPR repeat BTAD PF03704.17 ORX72058.1 - 0.05 14.0 0.4 8.2 6.9 0.0 3.6 3 0 0 3 3 3 0 Bacterial transcriptional activator domain DUF1570 PF07607.11 ORX72058.1 - 0.12 12.6 0.6 1.5 9.1 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1570) Fis1_TPR_C PF14853.6 ORX72058.1 - 0.13 12.3 0.4 27 4.9 0.0 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat VPS13_mid_rpt PF16910.5 ORX72059.1 - 0.08 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Repeating coiled region of VPS13 Rad60-SLD_2 PF13881.6 ORX72063.1 - 7.6e-18 64.6 0.0 8.4e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX72063.1 - 2.1e-08 33.8 0.1 7.8e-08 32.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 ORX72063.1 - 0.046 14.3 0.0 0.051 14.1 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TPR_1 PF00515.28 ORX72064.1 - 2.7e-13 49.1 0.0 8e-08 31.8 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX72064.1 - 6.5e-13 47.7 0.0 1.7e-06 27.7 0.0 2.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX72064.1 - 9e-08 31.7 0.2 1.1e-06 28.2 0.0 2.0 1 1 1 2 2 2 1 TPR repeat TPR_8 PF13181.6 ORX72064.1 - 1.6e-07 31.0 0.1 0.0015 18.6 0.0 2.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX72064.1 - 1e-06 28.9 0.1 0.045 14.0 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX72064.1 - 3.9e-05 23.7 0.0 7.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX72064.1 - 6.4e-05 22.7 0.1 0.01 15.7 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72064.1 - 0.00054 20.6 0.0 0.011 16.4 0.0 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX72064.1 - 0.00096 19.6 0.0 0.0018 18.7 0.0 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX72064.1 - 0.003 18.2 0.0 0.0041 17.8 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF5113 PF17140.4 ORX72064.1 - 0.0064 16.3 0.0 0.0067 16.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5113) BTAD PF03704.17 ORX72064.1 - 0.011 16.1 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial transcriptional activator domain DUF3856 PF12968.7 ORX72064.1 - 0.045 13.8 0.3 1.4 8.9 0.3 2.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) MAS20 PF02064.15 ORX72064.1 - 0.049 13.7 0.0 0.077 13.1 0.0 1.3 1 1 0 1 1 1 0 MAS20 protein import receptor DUF667 PF05018.13 ORX72065.1 - 1.4e-52 178.2 0.0 1.5e-52 178.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) CRAL_TRIO_N PF03765.15 ORX72065.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain Cyclin_N PF00134.23 ORX72067.1 - 1.1e-39 135.0 0.3 2.5e-39 133.9 0.1 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ORX72067.1 - 1.6e-20 73.3 0.0 3.1e-13 49.9 0.0 2.5 2 0 0 2 2 2 2 Cyclin, C-terminal domain MOSC PF03473.17 ORX72068.1 - 7.4e-24 84.2 0.0 2.1e-23 82.8 0.0 1.7 2 0 0 2 2 2 1 MOSC domain MOSC_N PF03476.16 ORX72068.1 - 1.2e-11 44.5 0.0 4.2e-11 42.8 0.0 1.9 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 ORX72068.1 - 4.3e-11 42.4 0.0 4.2e-06 26.0 0.0 2.9 2 1 0 2 2 2 2 Aminotransferase class-V SET PF00856.28 ORX72069.1 - 0.12 12.7 0.0 5.3 7.4 0.0 3.0 2 1 0 2 2 2 0 SET domain Mitochondr_Som1 PF11093.8 ORX72070.1 - 3.4e-07 30.1 0.2 4.2e-07 29.9 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Rcd1 PF04078.13 ORX72071.1 - 7.1e-92 307.4 1.1 7.9e-92 307.2 1.1 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like HSF_DNA-bind PF00447.17 ORX72072.1 - 6.8e-23 81.1 0.0 1.1e-22 80.5 0.0 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Cas9_C PF18525.1 ORX72072.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Cas9 C-terminal domain DUF687 PF05095.12 ORX72072.1 - 0.27 9.7 0.4 0.35 9.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF687) LRR_6 PF13516.6 ORX72074.1 - 0.0021 17.9 0.5 3.4 8.0 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 ORX72074.1 - 0.035 14.6 0.1 55 4.9 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat Fe_hyd_lg_C PF02906.14 ORX72075.1 - 6e-73 245.5 0.0 1.1e-72 244.7 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain FAD_syn PF06574.12 ORX72075.1 - 0.00092 19.1 0.6 0.0041 17.0 0.2 2.0 2 0 0 2 2 2 1 FAD synthetase Fe_hyd_SSU PF02256.17 ORX72075.1 - 0.017 15.1 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Iron hydrogenase small subunit Antimicrobial_7 PF08102.11 ORX72075.1 - 0.047 13.9 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 Scorpion antimicrobial peptide PrpR_N PF06506.11 ORX72075.1 - 0.085 12.4 0.1 0.22 11.1 0.1 1.6 1 0 0 1 1 1 0 Propionate catabolism activator DUF3791 PF12668.7 ORX72075.1 - 0.13 12.3 0.0 15 5.7 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3791) Ribosomal_S3_C PF00189.20 ORX72076.1 - 4.3e-25 88.1 1.6 1.2e-24 86.6 0.8 2.1 2 1 1 3 3 3 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ORX72076.1 - 1.4e-12 47.3 0.0 2.6e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 KH domain SDA1 PF05285.12 ORX72078.1 - 0.6 9.5 21.8 0.88 8.9 21.8 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ORX72078.1 - 4.4 5.4 20.9 6.3 4.9 20.9 1.1 1 0 0 1 1 1 0 Nop14-like family Rad33 PF08730.10 ORX72081.1 - 0.06 13.4 0.4 0.13 12.2 0.4 1.5 1 0 0 1 1 1 0 Rad33 ATG_C PF09333.11 ORX72081.1 - 6.8 7.1 7.9 9 6.7 0.2 3.0 2 1 1 3 3 3 0 Autophagy-related protein C terminal domain NAPRTase PF04095.16 ORX72082.1 - 5.9e-50 170.1 0.3 6e-35 121.0 0.3 2.3 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ORX72082.1 - 2.5e-27 95.7 0.0 2.2e-26 92.7 0.0 2.4 2 1 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain MCD PF05292.11 ORX72083.1 - 4.6e-63 213.2 0.0 2.9e-38 131.9 0.0 2.1 1 1 1 2 2 2 2 Malonyl-CoA decarboxylase C-terminal domain zf-DBF PF07535.12 ORX72084.1 - 7.4e-18 64.4 0.1 1.5e-17 63.4 0.1 1.5 1 0 0 1 1 1 1 DBF zinc finger Dfp1_Him1_M PF08630.10 ORX72084.1 - 2.2e-17 63.4 0.0 2.2e-17 63.4 0.0 3.2 4 1 0 4 4 4 1 Dfp1/Him1, central region MPP6 PF10175.9 ORX72084.1 - 3.2e-13 50.3 13.3 1.2e-12 48.5 13.3 2.1 1 1 0 1 1 1 1 M-phase phosphoprotein 6 DUF4936 PF16290.5 ORX72084.1 - 0.066 13.9 2.2 0.24 12.1 2.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4936) FANCM-MHF_bd PF16783.5 ORX72084.1 - 0.32 11.1 3.4 0.17 11.9 0.5 2.0 2 0 0 2 2 2 0 FANCM to MHF binding domain Glyco_hydro_31 PF01055.26 ORX72085.1 - 4.1e-139 464.6 2.5 5.5e-139 464.2 2.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX72085.1 - 2e-25 89.2 0.0 3.7e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX72085.1 - 2.5e-08 34.1 0.4 5.2e-08 33.1 0.4 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like Pyridoxal_deC PF00282.19 ORX72086.1 - 9.6e-117 389.8 0.0 1.1e-116 389.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 ORX72086.1 - 0.00023 20.5 0.0 0.00037 19.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II VirionAssem_T7 PF11653.8 ORX72087.1 - 0.019 15.5 2.3 0.031 14.8 2.3 1.3 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein V-ATPase_G_2 PF16999.5 ORX72087.1 - 0.035 14.5 2.2 0.034 14.6 1.6 1.3 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Apolipoprotein PF01442.18 ORX72087.1 - 0.069 13.0 1.2 0.081 12.8 1.2 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain LPP20 PF02169.16 ORX72088.1 - 0.041 14.2 1.0 0.056 13.8 1.0 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein LPD38 PF18857.1 ORX72088.1 - 0.084 13.0 0.4 0.18 11.9 0.3 1.5 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 G_glu_transpept PF01019.21 ORX72089.1 - 2.1e-150 501.9 0.3 5.9e-150 500.4 0.3 1.7 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase Rrp44_CSD1 PF17216.3 ORX72090.1 - 0.21 11.3 1.2 0.62 9.8 1.2 1.8 1 0 0 1 1 1 0 Rrp44-like cold shock domain FliD_N PF02465.18 ORX72090.1 - 1.6 9.4 13.1 1.7 9.4 0.9 3.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Pkinase PF00069.25 ORX72095.1 - 3.3e-50 170.9 0.0 4.8e-50 170.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX72095.1 - 8e-28 97.4 0.0 1.3e-27 96.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX72095.1 - 1.1e-05 25.5 2.4 7.5e-05 22.8 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX72095.1 - 0.0009 18.6 0.0 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX72095.1 - 0.0053 16.1 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX72095.1 - 0.11 12.2 0.0 3.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX72095.1 - 0.21 10.5 0.1 0.43 9.5 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 ORX72095.1 - 0.23 10.4 0.1 0.34 9.8 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Homeodomain PF00046.29 ORX72096.1 - 2.4e-08 33.7 0.7 4.9e-08 32.7 0.7 1.6 1 0 0 1 1 1 1 Homeodomain NDUF_B4 PF07225.12 ORX72097.1 - 4.8e-05 23.2 0.1 5.5e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GWT1 PF06423.12 ORX72098.1 - 6.6e-34 117.2 0.3 6.6e-34 117.2 0.3 2.5 2 1 0 2 2 2 1 GWT1 Tail_VII PF17091.5 ORX72098.1 - 0.12 12.3 3.1 0.35 10.8 3.1 1.8 1 0 0 1 1 1 0 Inovirus G7P protein G10 PF01125.17 ORX72099.1 - 1.4e-67 226.0 5.9 1.6e-67 225.8 5.9 1.0 1 0 0 1 1 1 1 G10 protein DUF5357 PF17310.2 ORX72099.1 - 0.047 12.3 0.1 0.058 11.9 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5357) SNF2_N PF00176.23 ORX72100.1 - 8.1e-66 222.1 0.0 2.3e-65 220.6 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX72100.1 - 4.4e-18 65.6 0.0 1e-17 64.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX72100.1 - 0.00032 20.7 0.0 0.00064 19.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX72100.1 - 0.0028 16.9 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 ORX72100.1 - 0.011 15.0 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 AAA_34 PF13872.6 ORX72100.1 - 0.055 12.4 0.1 0.12 11.2 0.1 1.6 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 WD40 PF00400.32 ORX72101.1 - 5.5e-06 27.0 0.4 0.21 12.5 0.1 4.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Ribo_biogen_C PF04034.13 ORX72102.1 - 2.9e-53 178.9 0.0 3.8e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ORX72102.1 - 1.8e-12 46.9 0.2 3.8e-12 45.8 0.0 1.6 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI LRR_8 PF13855.6 ORX72103.1 - 5e-10 39.0 7.6 2.5e-05 23.9 3.6 3.9 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ORX72103.1 - 3.9e-09 36.6 4.6 0.0035 17.7 0.1 4.7 3 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX72103.1 - 0.0091 15.5 0.0 0.033 13.7 0.0 1.8 1 1 1 2 2 2 1 Leucine-rich repeat SUKH_5 PF14567.6 ORX72103.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall LRR_1 PF00560.33 ORX72103.1 - 4.1 8.3 4.6 3.1e+02 2.6 0.0 5.3 7 0 0 7 7 7 0 Leucine Rich Repeat ATP-synt_D PF01813.17 ORX72104.1 - 0.0012 18.7 0.0 0.0016 18.4 0.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Peptidase_M24 PF00557.24 ORX72105.1 - 2.6e-49 167.7 0.0 3.1e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 Pyrid_oxidase_2 PF13883.6 ORX72106.1 - 3.2e-22 79.3 0.0 4e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Dus PF01207.17 ORX72108.1 - 1e-42 146.3 0.0 1.3e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PcrB PF01884.17 ORX72108.1 - 0.049 13.1 0.0 0.084 12.3 0.0 1.3 1 0 0 1 1 1 0 PcrB family SidC_N PF18219.1 ORX72108.1 - 0.1 11.6 0.0 0.28 10.1 0.0 1.6 2 0 0 2 2 2 0 SidC N-terminal domain Peripla_BP_1 PF00532.21 ORX72108.1 - 0.14 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family His_biosynth PF00977.21 ORX72108.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein YL1_C PF08265.11 ORX72109.1 - 9.5e-15 54.1 1.2 1.6e-14 53.4 1.2 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain zf-HIT PF04438.16 ORX72109.1 - 0.00012 21.8 0.3 0.0002 21.1 0.3 1.4 1 0 0 1 1 1 1 HIT zinc finger Zn_clus PF00172.18 ORX72110.1 - 1.7e-05 24.8 9.9 2.7e-05 24.2 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ORX72110.1 - 0.046 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 PAS fold Nucleos_tra2_C PF07662.13 ORX72112.1 - 4.8e-67 225.8 4.5 4.8e-67 225.8 4.5 2.6 2 1 1 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ORX72112.1 - 1.7e-21 76.6 0.4 1.7e-21 76.6 0.4 3.0 4 1 1 5 5 5 1 Na+ dependent nucleoside transporter N-terminus Macoilin PF09726.9 ORX72112.1 - 0.29 9.6 0.7 0.42 9.1 0.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF4131 PF13567.6 ORX72112.1 - 2.1 8.0 7.3 8.1 6.1 0.3 3.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) DPM3 PF08285.11 ORX72112.1 - 8.5 6.6 7.0 44 4.4 0.5 2.9 1 1 1 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Nucleos_tra2_C PF07662.13 ORX72113.1 - 8e-67 225.1 4.7 8e-67 225.1 4.7 2.9 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ORX72113.1 - 3.1e-22 78.9 3.9 3.1e-22 78.9 3.9 3.2 5 0 0 5 5 5 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 ORX72113.1 - 0.0014 18.9 1.4 0.0014 18.9 1.4 3.5 4 0 0 4 4 4 1 Nucleoside recognition ECR1_N PF14382.6 ORX72114.1 - 2.7e-15 55.9 0.2 5.2e-15 55.0 0.2 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 ORX72114.1 - 3.6e-11 43.2 0.1 8.5e-11 42.0 0.1 1.7 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 ORX72114.1 - 0.0014 19.2 0.9 0.53 10.9 0.1 2.9 2 1 1 3 3 3 2 Exosome component EXOSC1/CSL4 S1 PF00575.23 ORX72114.1 - 0.075 13.4 0.1 0.39 11.1 0.0 2.2 3 0 0 3 3 3 0 S1 RNA binding domain ALAD PF00490.21 ORX72115.1 - 8.1e-126 419.5 0.0 9.5e-126 419.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF2045 PF09741.9 ORX72116.1 - 1.9e-35 122.4 0.0 2.8e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) DUF5579 PF17742.1 ORX72117.1 - 0.0089 15.6 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5579) Zn_ribbon_SprT PF17283.2 ORX72117.1 - 0.016 15.1 0.5 0.048 13.6 0.5 1.8 1 0 0 1 1 1 0 SprT-like zinc ribbon domain Zn_Tnp_IS91 PF14319.6 ORX72117.1 - 0.059 13.4 1.2 0.11 12.5 1.2 1.4 1 0 0 1 1 1 0 Transposase zinc-binding domain SNF2_N PF00176.23 ORX72118.1 - 6.3e-64 215.9 0.0 1.1e-63 215.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX72118.1 - 1.5e-17 63.9 0.0 3.5e-17 62.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ORX72118.1 - 4.4e-13 48.9 0.8 4.7e-07 29.6 0.4 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 ORX72118.1 - 1.3e-12 48.0 1.9 2.4e-12 47.1 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) ResIII PF04851.15 ORX72118.1 - 6.7e-09 36.0 0.0 2.6e-08 34.1 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 ORX72118.1 - 0.0036 17.5 0.1 0.019 15.2 0.0 2.2 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain CDH1_2_SANT_HL1 PF18375.1 ORX72118.1 - 0.0064 17.1 0.1 0.037 14.7 0.0 2.4 2 0 0 2 2 2 1 CDH1/2 SANT-Helical linker 1 SLIDE PF09111.10 ORX72118.1 - 0.013 15.5 0.0 0.074 13.1 0.0 2.3 2 0 0 2 2 2 0 SLIDE Myb_DNA-binding PF00249.31 ORX72118.1 - 0.043 14.0 0.0 1.8 8.8 0.0 3.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain HEAT PF02985.22 ORX72123.1 - 3e-08 33.2 2.0 3.4 8.2 0.2 5.5 5 0 0 5 5 5 3 HEAT repeat Pkinase PF00069.25 ORX72123.1 - 9.5e-06 25.2 0.0 8.6e-05 22.0 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain HEAT_2 PF13646.6 ORX72123.1 - 9.4e-05 22.7 0.2 0.04 14.3 0.3 3.6 2 1 3 5 5 5 2 HEAT repeats Pkinase_Tyr PF07714.17 ORX72123.1 - 0.0014 17.9 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Vac14_Fab1_bd PF12755.7 ORX72123.1 - 0.01 16.4 0.0 0.83 10.3 0.0 3.2 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ORX72123.1 - 0.05 14.1 3.7 6.3 7.4 1.5 3.4 3 0 0 3 3 3 0 HEAT-like repeat Adaptin_N PF01602.20 ORX72123.1 - 0.073 11.6 0.1 7.9 4.9 0.0 2.2 1 1 1 2 2 2 0 Adaptin N terminal region CLASP_N PF12348.8 ORX72123.1 - 0.11 12.0 0.0 13 5.3 0.0 2.6 2 1 0 2 2 2 0 CLASP N terminal Cnd1 PF12717.7 ORX72123.1 - 0.19 11.8 0.1 29 4.6 0.0 2.5 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 ORX72123.1 - 0.5 10.7 1.9 21 5.5 0.1 3.9 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion TPP_enzyme_N PF02776.18 ORX72124.1 - 2.5e-55 186.7 0.0 1.4e-54 184.3 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ORX72124.1 - 3.4e-50 169.8 1.1 2.3e-48 163.9 0.3 3.2 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ORX72124.1 - 1.1e-33 115.8 0.1 2.2e-32 111.7 0.1 2.5 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain ALS_ss_C PF10369.9 ORX72125.1 - 1.3e-17 63.7 0.1 1e-16 60.9 0.1 2.4 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 ORX72125.1 - 1.1e-14 53.9 0.0 2.4e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ORX72125.1 - 2.4e-09 36.9 0.0 4.1e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain ALS_ss_C PF10369.9 ORX72126.1 - 1.4e-18 66.9 0.1 4.4e-17 62.0 0.0 2.8 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 ORX72126.1 - 1.8e-13 50.0 0.0 2.9e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ORX72126.1 - 4.8e-08 32.7 0.0 7.6e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 ACT domain IlvN PF07991.12 ORX72127.1 - 1.2e-43 148.5 0.0 1.9e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ORX72127.1 - 9.3e-41 139.5 0.0 1.3e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 ORX72127.1 - 0.11 13.1 0.0 0.26 11.9 0.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Zn_clus PF00172.18 ORX72128.1 - 2.8e-10 40.2 9.4 6.1e-10 39.1 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX72128.1 - 0.0017 17.5 4.1 0.14 11.2 4.1 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain AT_hook PF02178.19 ORX72128.1 - 0.049 13.5 1.5 0.16 11.9 1.5 1.9 1 0 0 1 1 1 0 AT hook motif Ribosomal_L29e PF01779.17 ORX72129.1 - 1.4e-24 86.1 12.1 2e-24 85.6 12.1 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Glyco_tran_28_C PF04101.16 ORX72135.1 - 1.1e-30 106.8 0.0 1.3e-30 106.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pyridox_oxase_2 PF12766.7 ORX72136.1 - 4.6e-16 59.3 0.0 6.8e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ORX72136.1 - 4.3e-07 30.0 0.0 7.6e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF2443 PF10398.9 ORX72137.1 - 0.0059 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2443) zf-CCHC_3 PF13917.6 ORX72138.1 - 0.043 13.8 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle Fungal_trans PF04082.18 ORX72139.1 - 3.2e-13 49.3 0.0 5.2e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX72139.1 - 7e-09 35.7 8.2 1.4e-08 34.7 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prok-E2_C PF14459.6 ORX72139.1 - 0.066 13.4 0.2 0.78 9.9 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic E2 family C Pirin PF02678.16 ORX72142.1 - 3.4e-05 23.8 0.0 5.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Pirin Prot_ATP_OB_N PF17758.1 ORX72142.1 - 0.094 12.4 0.1 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain Ribosomal_L18A PF01775.17 ORX72144.1 - 7.1e-45 152.0 0.8 8.6e-45 151.7 0.8 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A GARS_A PF01071.19 ORX72145.1 - 2.9e-65 219.7 0.0 5e-65 218.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 ORX72145.1 - 1.6e-36 125.0 0.1 3.6e-35 120.6 0.1 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 ORX72145.1 - 4.6e-20 71.7 1.5 4.8e-19 68.4 1.5 2.5 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS_C PF02769.22 ORX72145.1 - 1.5e-18 67.4 0.2 1.1e-13 51.6 0.0 3.3 3 0 0 3 3 3 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 ORX72145.1 - 2.7e-14 53.6 0.3 2.7e-13 50.4 0.4 2.3 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Utp14 PF04615.13 ORX72146.1 - 1.3 7.5 24.1 1.4 7.4 24.1 1.0 1 0 0 1 1 1 0 Utp14 protein TRM13 PF05206.14 ORX72147.1 - 1.3e-45 156.0 0.4 5.2e-44 150.7 0.4 2.9 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-U11-48K PF05253.12 ORX72147.1 - 4.1e-07 29.8 0.6 1.3e-06 28.1 0.6 1.9 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger zf-TRM13_CCCH PF11722.8 ORX72147.1 - 0.0083 15.9 2.4 0.087 12.6 2.4 2.4 1 1 0 1 1 1 1 CCCH zinc finger in TRM13 protein GTP_EFTU PF00009.27 ORX72148.1 - 8.8e-30 103.7 1.2 3.1e-26 92.1 1.5 3.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ORX72148.1 - 8.4e-13 48.2 0.0 2.5e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX72148.1 - 3.5e-09 36.9 1.8 9.1e-09 35.6 1.8 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX72148.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX72148.1 - 6.3e-05 22.5 0.1 0.00023 20.6 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 ORX72149.1 - 1.4e-23 83.8 0.0 2.1e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX72149.1 - 1.6e-07 31.8 0.5 7.8e-07 29.6 0.2 2.2 1 1 1 2 2 2 1 AAA domain ADK PF00406.22 ORX72149.1 - 2.1e-05 24.7 0.4 0.0015 18.6 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase AAA PF00004.29 ORX72149.1 - 3.4e-05 24.3 0.3 0.00018 22.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX72149.1 - 0.00055 20.4 0.2 0.0014 19.1 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ORX72149.1 - 0.00056 20.2 1.5 0.0008 19.7 0.6 1.7 1 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX72149.1 - 0.0012 18.7 1.6 0.0014 18.6 0.1 1.8 2 1 0 2 2 2 1 NTPase RuvB_N PF05496.12 ORX72149.1 - 0.0024 17.6 0.1 0.0049 16.6 0.1 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain SKI PF01202.22 ORX72149.1 - 0.003 17.7 0.3 0.0048 17.0 0.3 1.3 1 1 0 1 1 1 1 Shikimate kinase AAA_5 PF07728.14 ORX72149.1 - 0.0039 17.2 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Radial_spoke_3 PF06098.11 ORX72149.1 - 0.0046 16.3 0.3 0.0066 15.8 0.3 1.2 1 0 0 1 1 1 1 Radial spoke protein 3 Zeta_toxin PF06414.12 ORX72149.1 - 0.0049 16.2 0.1 0.015 14.5 0.0 1.9 2 1 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 ORX72149.1 - 0.0051 17.1 2.2 0.018 15.3 2.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX72149.1 - 0.0059 16.8 1.6 0.056 13.6 0.3 2.3 1 1 1 3 3 2 1 AAA domain dNK PF01712.19 ORX72149.1 - 0.0079 16.1 3.6 0.069 13.0 0.1 2.2 2 1 0 2 2 2 1 Deoxynucleoside kinase AAA_24 PF13479.6 ORX72149.1 - 0.0084 15.8 0.5 0.032 13.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ORX72149.1 - 0.013 14.9 0.3 0.046 13.1 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_11 PF13086.6 ORX72149.1 - 0.025 14.4 0.3 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX72149.1 - 0.037 14.4 0.1 0.17 12.3 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ATPase PF06745.13 ORX72149.1 - 0.038 13.3 1.7 0.05 13.0 0.2 1.8 2 0 0 2 2 2 0 KaiC KTI12 PF08433.10 ORX72149.1 - 0.045 13.2 0.1 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 TrwB_AAD_bind PF10412.9 ORX72149.1 - 0.06 12.2 0.3 0.11 11.4 0.1 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 ORX72149.1 - 0.063 12.3 0.8 0.13 11.3 0.8 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 ORX72149.1 - 0.063 13.0 1.0 0.1 12.3 0.4 1.6 2 0 0 2 2 2 0 AAA domain Mur_ligase_M PF08245.12 ORX72149.1 - 0.07 13.1 1.5 0.5 10.3 0.3 2.0 2 0 0 2 2 2 0 Mur ligase middle domain Sigma54_activat PF00158.26 ORX72149.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ORX72149.1 - 0.086 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein MCM PF00493.23 ORX72149.1 - 0.095 11.8 1.9 0.26 10.3 0.1 2.5 2 2 1 3 3 3 0 MCM P-loop domain Sacchrp_dh_NADP PF03435.18 ORX72149.1 - 0.097 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Sigma54_activ_2 PF14532.6 ORX72149.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.15 ORX72149.1 - 0.15 12.0 1.2 0.34 10.9 1.2 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 ORX72149.1 - 0.16 12.5 2.1 0.31 11.5 2.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX72149.1 - 0.2 12.0 8.2 1.3 9.4 8.2 2.4 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX72149.1 - 0.51 10.4 2.8 0.34 10.9 0.3 1.9 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE His_Phos_2 PF00328.22 ORX72150.1 - 2.1e-17 63.5 0.0 2.4e-15 56.8 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPR_2 PF13041.6 ORX72151.1 - 3.3e-11 43.2 0.1 1e-09 38.4 0.1 2.2 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ORX72151.1 - 5.7e-10 38.8 0.5 2.1e-06 27.6 0.0 3.2 3 0 0 3 3 3 2 PPR repeat PPR_1 PF12854.7 ORX72151.1 - 3.4e-07 29.8 0.1 1.5e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 PPR repeat PPR_long PF17177.4 ORX72151.1 - 0.00014 21.3 0.2 0.00019 20.9 0.2 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF4135 PF13575.6 ORX72151.1 - 0.0032 16.8 0.2 0.0043 16.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PPR_3 PF13812.6 ORX72151.1 - 0.032 14.3 0.3 0.2 11.7 0.1 2.1 1 1 1 2 2 2 0 Pentatricopeptide repeat domain TPR_14 PF13428.6 ORX72151.1 - 0.041 14.7 0.4 2 9.4 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 ORX72151.1 - 0.051 13.3 0.3 1 9.0 0.1 2.1 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_12 PF13424.6 ORX72151.1 - 0.053 13.8 0.0 3 8.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP13 PF12921.7 ORX72151.1 - 0.058 13.3 0.0 11 5.9 0.0 2.1 1 1 1 2 2 2 0 Mitochondrial ATPase expression Yip1 PF04893.17 ORX72152.1 - 4.2e-16 59.1 16.7 7.7e-16 58.3 16.7 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 ORX72152.1 - 0.41 10.4 10.0 0.53 10.0 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) TFIIA PF03153.13 ORX72155.1 - 3.5 7.5 13.9 0.42 10.6 9.8 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit YABBY PF04690.13 ORX72160.1 - 2.7e-08 34.6 0.1 2.7e-08 34.6 0.1 1.8 1 1 1 2 2 2 1 YABBY protein Ccdc124 PF06244.12 ORX72160.1 - 0.00021 21.8 1.8 0.00024 21.7 0.3 1.7 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 NCD3G PF07562.14 ORX72160.1 - 0.00028 20.8 2.2 0.00043 20.2 2.2 1.3 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR HMG_box PF00505.19 ORX72160.1 - 0.00091 19.6 0.8 0.0019 18.6 0.3 1.8 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX72160.1 - 0.02 15.5 2.2 0.024 15.2 0.4 1.9 2 0 0 2 2 2 0 HMG-box domain KRAP_IP3R_bind PF14722.6 ORX72160.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain VEK-30 PF12107.8 ORX72160.1 - 0.29 11.1 1.9 0.47 10.4 1.9 1.3 1 0 0 1 1 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway Methyltransf_33 PF10017.9 ORX72161.1 - 4.1e-65 219.9 0.0 6.1e-65 219.4 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 ORX72161.1 - 9.1e-26 91.0 0.1 2.6e-25 89.5 0.1 1.7 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 SSF PF00474.17 ORX72162.1 - 5.7e-06 25.4 4.4 5.7e-06 25.4 4.4 2.5 2 1 1 3 3 3 1 Sodium:solute symporter family NAD_binding_6 PF08030.12 ORX72163.1 - 6.8e-14 52.3 0.0 3.4e-13 50.0 0.0 2.0 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ORX72163.1 - 2e-13 50.5 13.6 3.9e-13 49.6 13.6 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ORX72163.1 - 1.9e-11 44.0 0.0 2.3e-10 40.5 0.0 2.6 2 1 0 2 2 2 1 FAD-binding domain RhoGEF PF00621.20 ORX72164.1 - 2.9e-29 102.6 0.0 5.6e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain S1 PF00575.23 ORX72165.1 - 1.9e-30 105.0 26.3 1.2e-09 38.4 0.2 11.3 12 1 0 12 12 12 7 S1 RNA binding domain TPR_14 PF13428.6 ORX72165.1 - 3.1e-05 24.4 1.3 0.14 13.1 0.0 4.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX72165.1 - 0.0063 17.0 0.1 6.7 7.3 0.0 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat Suf PF05843.14 ORX72165.1 - 0.049 13.6 0.3 0.049 13.6 0.3 3.5 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) ID PF18543.1 ORX72165.1 - 0.13 12.3 0.2 10 6.2 0.1 3.5 3 0 0 3 3 3 0 Intracellular delivery domain Apt1 PF10351.9 ORX72165.1 - 0.83 8.4 14.3 0.2 10.5 4.5 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain BUD22 PF09073.10 ORX72165.1 - 2.4 7.4 26.2 3.1 7.0 13.1 2.5 2 0 0 2 2 2 0 BUD22 RasGEF PF00617.19 ORX72166.1 - 2.6e-43 148.3 0.0 2.9e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 RasGEF domain WW PF00397.26 ORX72167.1 - 0.001 19.1 1.8 0.0012 18.8 0.3 1.9 2 0 0 2 2 2 1 WW domain Pyr_redox_2 PF07992.14 ORX72168.1 - 9.4e-40 136.7 0.4 1.3e-38 132.9 0.3 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX72168.1 - 2e-23 82.7 0.1 4.3e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 ORX72168.1 - 4.3e-06 26.2 3.2 0.00062 19.1 3.2 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX72168.1 - 4.4e-06 25.6 1.6 0.0019 17.0 1.2 3.0 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ORX72168.1 - 0.0016 17.6 2.1 0.0016 17.6 2.1 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ORX72168.1 - 0.0016 17.6 3.7 0.0017 17.5 2.6 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ORX72168.1 - 0.013 16.0 4.1 3.5 8.2 0.1 3.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX72168.1 - 0.026 13.9 4.2 0.041 13.2 4.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 ORX72168.1 - 0.038 13.2 0.2 0.11 11.7 0.2 1.8 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 ORX72168.1 - 0.2 11.9 5.0 0.49 10.7 4.6 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX72168.1 - 0.71 9.4 4.4 1.7 8.2 2.7 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase MMR_HSR1_C PF08438.10 ORX72169.1 - 4.1e-33 114.3 0.0 8.2e-33 113.3 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 ORX72169.1 - 1.9e-20 73.1 0.0 5.3e-20 71.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX72169.1 - 5.8e-10 38.9 0.0 1.6e-08 34.2 0.0 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX72169.1 - 0.0024 18.0 0.0 0.0072 16.4 0.0 1.8 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 ORX72169.1 - 0.015 15.2 0.0 2.6 7.9 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 ORX72169.1 - 0.045 13.3 0.1 0.64 9.5 0.0 2.9 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain SPC25 PF06703.11 ORX72170.1 - 2.8e-39 134.5 0.1 3.3e-39 134.3 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) SK_channel PF03530.14 ORX72170.1 - 0.0099 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 1 Calcium-activated SK potassium channel IBD PF10416.9 ORX72170.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD DEAD PF00270.29 ORX72172.1 - 5.8e-28 97.8 0.1 9e-26 90.7 0.0 2.2 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX72172.1 - 1.3e-27 96.3 0.2 1e-26 93.4 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ORX72172.1 - 0.053 12.8 0.1 0.093 12.1 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Cys_Met_Meta_PP PF01053.20 ORX72173.1 - 1.1e-33 116.3 0.0 1.6e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX72173.1 - 1.9e-06 27.3 0.0 3.3e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Rpn3_C PF08375.11 ORX72174.1 - 7.8e-25 87.1 0.7 2.4e-24 85.5 0.7 1.8 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 ORX72174.1 - 9.3e-22 77.5 0.7 2.9e-21 75.9 0.2 2.1 2 0 0 2 2 2 1 PCI domain SAC3_GANP PF03399.16 ORX72174.1 - 0.013 14.9 0.4 0.026 13.9 0.4 1.5 1 0 0 1 1 1 0 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ORX72174.1 - 0.051 13.6 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family VMA21 PF09446.10 ORX72175.1 - 1e-05 25.5 8.7 1.8e-05 24.8 8.7 1.4 1 0 0 1 1 1 1 VMA21-like domain PIP5K PF01504.18 ORX72176.1 - 2.8e-83 279.3 0.0 4.4e-83 278.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase NTP_transferase PF00483.23 ORX72179.1 - 1.2e-11 44.7 0.0 1.5e-10 41.1 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 ORX72179.1 - 3.8e-09 35.9 4.6 5.6e-06 25.9 4.8 3.8 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX72179.1 - 9.5e-08 32.6 0.0 1.3e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 ORX72179.1 - 7.9e-05 21.0 1.9 0.00011 20.5 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 ORX72179.1 - 0.023 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase Fucokinase PF07959.12 ORX72179.1 - 0.093 11.6 1.6 0.3 10.0 1.5 1.7 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 ORX72179.1 - 0.89 9.4 5.9 2.6 7.9 2.8 3.1 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase MAM33 PF02330.16 ORX72180.1 - 4.1e-52 177.2 5.2 4.7e-52 177.0 5.2 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein CYTH PF01928.21 ORX72180.1 - 0.0081 16.1 0.7 0.15 12.0 0.3 2.3 1 1 1 2 2 2 1 CYTH domain Peptidase_M24 PF00557.24 ORX72181.1 - 8e-21 74.7 0.5 1.4e-20 73.9 0.5 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M1 PF01433.20 ORX72182.1 - 3.2e-47 160.9 0.0 5.6e-47 160.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ORX72182.1 - 2.2e-37 127.6 0.1 4.1e-37 126.7 0.1 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ORX72182.1 - 2.8e-26 92.9 0.1 4.7e-26 92.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain GIT_SHD PF08518.11 ORX72183.1 - 7.4e-22 76.7 4.5 2.7e-12 46.1 0.2 2.4 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Trm112p PF03966.16 ORX72185.1 - 1.5e-13 51.1 0.0 1.9e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein zf-FCS PF06467.14 ORX72185.1 - 0.055 13.4 0.0 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DnaJ PF00226.31 ORX72188.1 - 6.6e-24 83.8 0.3 2.2e-23 82.2 0.3 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 ORX72188.1 - 6e-09 36.0 11.1 1.2e-06 28.6 4.4 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX72188.1 - 7.7e-07 29.3 6.4 0.0043 17.4 1.2 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ORX72188.1 - 4e-06 27.1 9.1 0.0046 17.3 0.5 3.2 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX72188.1 - 0.00015 22.3 3.5 0.026 15.4 0.1 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX72188.1 - 0.0055 17.1 7.7 0.037 14.5 0.4 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX72188.1 - 0.064 13.7 1.6 13 6.4 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2HE PF16278.5 ORX72188.1 - 0.13 12.7 6.7 0.7 10.4 0.1 4.3 5 0 0 5 5 4 0 C2HE / C2H2 / C2HC zinc-binding finger APP_amyloid PF10515.9 ORX72188.1 - 0.16 12.5 4.8 0.076 13.5 1.2 2.4 2 0 0 2 2 2 0 Beta-amyloid precursor protein C-terminus DUF2256 PF10013.9 ORX72188.1 - 1.8 8.8 4.9 2.5 8.3 0.2 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_6 PF13912.6 ORX72188.1 - 7.5 6.7 6.6 4.5 7.4 0.2 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger IBR PF01485.21 ORX72189.1 - 1.4e-19 70.1 45.9 8.6e-11 41.9 5.9 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ORX72189.1 - 0.00031 20.7 4.3 0.00031 20.7 4.3 3.6 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX72189.1 - 0.0015 18.8 3.5 0.0015 18.8 3.5 4.0 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 ORX72189.1 - 0.0016 18.3 2.2 0.0016 18.3 2.2 4.3 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX72189.1 - 0.013 15.5 5.7 0.013 15.5 5.7 3.4 2 1 1 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX72189.1 - 0.014 15.2 2.6 0.014 15.2 2.6 4.5 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Elong_Iki1 PF10483.9 ORX72190.1 - 8.7e-28 97.7 0.3 4e-27 95.5 0.3 1.9 1 1 0 1 1 1 1 Elongator subunit Iki1 SPACA7 PF15307.6 ORX72190.1 - 0.0014 18.8 0.3 0.011 16.0 0.2 2.1 2 0 0 2 2 2 1 Sperm acrosome-associated protein 7 FYDLN_acid PF09538.10 ORX72190.1 - 1.5 9.5 6.5 2.5 8.8 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) UQ_con PF00179.26 ORX72191.1 - 4.6e-53 178.6 0.0 5.1e-53 178.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX72191.1 - 0.00082 19.1 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ORX72191.1 - 0.02 15.2 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 ORX72191.1 - 0.033 14.0 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain Tim17 PF02466.19 ORX72193.1 - 4.6e-11 43.1 1.2 4.2e-10 40.0 0.6 2.1 2 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF4956 PF16316.5 ORX72193.1 - 0.011 15.4 0.2 0.023 14.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4956) TetR_C_12 PF16914.5 ORX72193.1 - 0.022 14.9 0.1 2 8.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial transcriptional repressor C-terminal RTA1 PF04479.13 ORX72194.1 - 9.9e-13 48.2 7.3 1.1e-12 48.1 6.8 1.3 1 1 0 1 1 1 1 RTA1 like protein DUF3995 PF13160.6 ORX72194.1 - 0.0058 17.0 0.3 0.0058 17.0 0.3 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF3995) ECF-ribofla_trS PF07155.12 ORX72194.1 - 0.18 11.8 7.4 0.079 12.9 0.6 2.5 2 1 0 2 2 2 0 ECF-type riboflavin transporter, S component DUF373 PF04123.13 ORX72194.1 - 1.2 8.6 6.8 2.2 7.6 6.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF4131 PF13567.6 ORX72194.1 - 2.6 7.7 5.5 0.52 10.0 0.3 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF4293 PF14126.6 ORX72194.1 - 3.7 7.8 7.4 0.28 11.4 0.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) W2 PF02020.18 ORX72196.1 - 5.9e-13 48.8 1.1 5.9e-13 48.8 1.1 2.2 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 ORX72196.1 - 9.8e-11 40.9 10.6 3.2e-06 26.7 4.8 4.2 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 ORX72196.1 - 7.2e-05 22.5 0.0 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ORX72196.1 - 0.00037 20.9 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 ORX72196.1 - 0.023 13.7 0.0 0.048 12.6 0.0 1.5 1 0 0 1 1 1 0 L-fucokinase SOR_SNZ PF01680.17 ORX72196.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 SOR/SNZ family Hexapep_2 PF14602.6 ORX72196.1 - 0.16 11.8 9.5 1.7 8.4 2.5 4.1 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase BTB_2 PF02214.22 ORX72197.1 - 7.8e-06 26.2 0.0 6.2e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 ORX72197.1 - 4.1e-05 23.6 0.0 0.0013 18.8 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain DUF1560 PF07597.11 ORX72197.1 - 0.014 15.4 0.0 0.038 14.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1560) AraC_binding PF02311.19 ORX72197.1 - 0.12 12.2 0.2 0.3 11.0 0.2 1.8 1 1 0 1 1 1 0 AraC-like ligand binding domain DAD PF02109.16 ORX72198.1 - 1.9e-37 127.9 1.0 2.1e-37 127.7 1.0 1.0 1 0 0 1 1 1 1 DAD family BRCA-2_OB1 PF09103.10 ORX72199.1 - 6.1e-30 103.7 0.0 2.4e-29 101.8 0.0 2.0 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 ORX72199.1 - 6.9e-12 45.4 0.0 7.1e-11 42.1 0.2 2.1 2 0 0 2 2 2 1 BRCA2, helical Tower PF09121.10 ORX72199.1 - 0.0047 17.1 0.6 0.0098 16.1 0.6 1.5 1 0 0 1 1 1 1 Tower Peptidase_M1 PF01433.20 ORX72200.1 - 1.5e-44 152.2 0.0 2.3e-44 151.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ORX72200.1 - 4.5e-36 123.4 0.0 1.1e-35 122.2 0.0 1.7 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ORX72200.1 - 2.5e-14 53.9 0.1 7.2e-14 52.4 0.1 1.7 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain PAC3 PF10178.9 ORX72200.1 - 0.004 17.3 0.0 0.017 15.3 0.0 2.1 2 0 0 2 2 2 1 Proteasome assembly chaperone 3 Peptidase_M61 PF05299.12 ORX72200.1 - 0.24 11.8 1.4 4.2 7.8 1.3 2.7 2 1 0 2 2 2 0 M61 glycyl aminopeptidase DUF726 PF05277.12 ORX72201.1 - 9.6e-62 208.9 0.6 2.6e-61 207.4 0.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF726) VirJ PF06057.11 ORX72201.1 - 0.034 14.0 0.0 0.13 12.1 0.0 1.9 1 1 1 2 2 2 0 Bacterial virulence protein (VirJ) DUF900 PF05990.12 ORX72201.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 ORX72201.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Cutinase PF01083.22 ORX72201.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Cutinase Palm_thioest PF02089.15 ORX72201.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 ORX72201.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold HMG_box PF00505.19 ORX72202.1 - 4.4e-11 43.0 2.8 2.8e-10 40.5 2.8 2.0 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX72202.1 - 1.5e-05 25.5 0.2 3.3e-05 24.4 0.1 1.7 1 1 1 2 2 2 1 HMG-box domain LSM PF01423.22 ORX72203.1 - 3.3e-17 61.9 0.3 4.2e-17 61.6 0.3 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_S10 PF00338.22 ORX72204.1 - 1.6e-28 98.8 0.3 2e-28 98.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PriA_C PF18074.1 ORX72204.1 - 0.042 14.7 0.1 0.075 13.9 0.1 1.4 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain PP2C PF00481.21 ORX72205.1 - 8.4e-28 97.7 0.0 1.6e-20 73.8 0.1 2.5 1 1 1 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 ORX72205.1 - 0.037 14.0 0.0 0.081 12.8 0.0 1.5 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Hydrolase_6 PF13344.6 ORX72206.1 - 1.4e-16 60.4 0.0 5.5e-16 58.5 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX72206.1 - 1.5e-09 37.8 0.1 4.6e-09 36.2 0.1 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 ORX72206.1 - 0.02 15.0 0.0 0.05 13.7 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX72206.1 - 0.13 12.6 0.0 0.2 11.9 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase FAD_binding_1 PF00667.20 ORX72207.1 - 7.7e-54 182.6 0.0 1.1e-53 182.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ORX72207.1 - 0.055 14.1 0.1 0.13 12.9 0.1 1.6 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain RRM_1 PF00076.22 ORX72208.1 - 1.9e-15 56.4 0.3 3.2e-07 30.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_2 PF07724.14 ORX72210.1 - 1.1e-21 77.7 0.0 1.2e-21 77.6 0.0 1.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ORX72210.1 - 2.3e-06 27.7 0.0 2.6e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Clp_N PF02861.20 ORX72211.1 - 0.015 15.5 0.0 0.06 13.5 0.0 1.9 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component HSF_DNA-bind PF00447.17 ORX72212.1 - 6e-11 42.8 0.0 9.4e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding Pex14_N PF04695.13 ORX72212.1 - 0.001 19.8 13.3 0.0013 19.4 13.3 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Amelogenin PF02948.15 ORX72212.1 - 0.061 14.0 25.3 0.087 13.5 25.3 1.2 1 0 0 1 1 1 0 Amelogenin PepSY_TM PF03929.16 ORX72212.1 - 0.074 12.7 1.2 0.077 12.6 1.2 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Ndc1_Nup PF09531.10 ORX72212.1 - 0.094 11.4 3.2 0.091 11.4 3.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF702 PF05142.12 ORX72212.1 - 0.33 11.4 4.1 0.55 10.7 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Presenilin PF01080.17 ORX72212.1 - 0.34 9.6 1.8 0.36 9.5 1.8 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 ORX72212.1 - 0.77 9.7 25.9 0.93 9.4 25.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 ORX72212.1 - 1.5 8.8 21.8 2.4 8.1 21.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CCDC53 PF10152.9 ORX72212.1 - 1.9 8.9 11.6 2.7 8.4 11.6 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF3729 PF12526.8 ORX72212.1 - 7.2 8.2 16.7 10 7.7 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) PAT1 PF09770.9 ORX72212.1 - 7.9 4.6 19.3 9.7 4.3 19.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Trypsin PF00089.26 ORX72213.1 - 0.0048 16.7 0.3 0.0062 16.4 0.3 1.1 1 0 0 1 1 1 1 Trypsin CytochromB561_N PF09786.9 ORX72215.1 - 2.1e-38 132.7 0.0 1e-37 130.4 0.0 1.8 2 0 0 2 2 2 1 Cytochrome B561, N terminal NPCC PF08058.11 ORX72215.1 - 1e-06 28.8 0.0 5.2e-06 26.5 0.0 2.1 2 1 0 2 2 2 1 Nuclear pore complex component zf-C2H2_jaz PF12171.8 ORX72216.1 - 3.9e-08 33.4 0.3 6.6e-08 32.6 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX72216.1 - 4.3e-07 30.1 0.4 7.1e-07 29.4 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 ORX72216.1 - 0.00014 21.6 0.2 0.00023 20.8 0.2 1.4 1 0 0 1 1 1 1 U1 zinc finger SNRNP27 PF08648.12 ORX72216.1 - 0.0007 19.6 0.3 0.0023 18.0 0.3 1.9 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2_2 PF12756.7 ORX72216.1 - 0.0056 17.0 1.1 0.0065 16.8 0.1 1.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) SURF2 PF05477.11 ORX72216.1 - 0.0078 15.9 7.1 0.014 15.1 7.0 1.4 1 1 0 1 1 1 1 Surfeit locus protein 2 (SURF2) zf_C2H2_ZHX PF18387.1 ORX72216.1 - 0.097 12.3 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain UNC-79 PF14776.6 ORX72216.1 - 0.18 10.5 2.8 0.23 10.2 2.8 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Phage_rep_org_N PF09681.10 ORX72216.1 - 0.27 11.2 4.1 0.44 10.5 4.1 1.3 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) SRP19 PF01922.17 ORX72216.1 - 0.42 11.6 3.1 0.74 10.8 3.1 1.3 1 0 0 1 1 1 0 SRP19 protein Pex26 PF07163.12 ORX72217.1 - 0.0092 15.3 0.7 0.13 11.5 0.1 2.6 3 0 0 3 3 3 1 Pex26 protein Peptidase_C2 PF00648.21 ORX72218.1 - 2.1e-41 141.9 0.0 3.2e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 ORX72218.1 - 1.7e-13 51.0 0.1 0.0017 18.6 0.0 5.1 4 1 0 4 4 4 3 Calpain large subunit, domain III MIT PF04212.18 ORX72218.1 - 2.2e-05 24.5 0.3 0.00011 22.2 0.1 2.1 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain SPRY PF00622.28 ORX72221.1 - 1.5e-11 44.4 0.0 2.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain E1_dh PF00676.20 ORX72222.1 - 4.2e-97 324.7 0.1 4.8e-97 324.5 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ORX72222.1 - 0.00046 20.0 1.0 0.0076 16.1 0.1 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ORX72222.1 - 0.0032 16.7 0.0 0.012 14.8 0.0 1.8 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase FAD_binding_6 PF00970.24 ORX72223.1 - 3.9e-32 110.5 0.0 5.8e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ORX72223.1 - 2.2e-31 108.7 0.0 3.2e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ORX72223.1 - 2.2e-06 27.9 0.0 0.00055 20.1 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ORX72223.1 - 0.098 12.9 0.0 0.28 11.4 0.0 1.8 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain NAD_Gly3P_dh_C PF07479.14 ORX72224.1 - 6.9e-48 162.5 1.1 1.6e-47 161.3 0.1 2.1 3 0 0 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ORX72224.1 - 2.3e-39 134.9 1.0 3.6e-39 134.3 1.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Poty_PP PF08440.10 ORX72224.1 - 0.19 10.8 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Potyviridae polyprotein SPRY PF00622.28 ORX72225.1 - 6.5e-15 55.3 0.1 1e-14 54.7 0.1 1.3 1 0 0 1 1 1 1 SPRY domain G_glu_transpept PF01019.21 ORX72226.1 - 9.1e-148 493.2 0.0 1e-147 493.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Bestrophin PF01062.21 ORX72227.1 - 4.3e-42 144.5 0.0 9e-42 143.5 0.0 1.4 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel APG9 PF04109.16 ORX72229.1 - 1.1e-158 529.3 12.1 1.8e-158 528.5 12.1 1.3 1 1 0 1 1 1 1 Autophagy protein Apg9 CTP_transf_like PF01467.26 ORX72230.1 - 3.3e-30 105.1 0.0 2e-14 54.0 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 ORX72230.1 - 0.03 14.2 0.2 1.3 8.9 0.3 2.7 3 1 0 3 3 3 0 FAD synthetase CoA_binding_3 PF13727.6 ORX72230.1 - 0.075 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 CoA-binding domain PC_rep PF01851.22 ORX72232.1 - 0.0066 16.8 17.6 14 6.3 0.0 7.6 8 0 0 8 8 8 3 Proteasome/cyclosome repeat Ank_2 PF12796.7 ORX72233.1 - 5.1e-24 84.7 4.5 1.6e-11 44.6 0.3 3.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX72233.1 - 3.3e-21 75.4 2.0 1.3e-08 35.2 0.2 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX72233.1 - 5.2e-18 63.3 0.3 0.00024 21.3 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ORX72233.1 - 4.5e-17 61.9 1.1 8.6e-09 35.5 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX72233.1 - 1.6e-14 53.6 2.4 7.3e-05 23.0 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeat Ribosomal_60s PF00428.19 ORX72233.1 - 0.099 13.2 4.0 0.2 12.2 4.0 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF799 PF05643.11 ORX72234.1 - 0.0058 16.2 0.0 0.0076 15.9 0.0 1.1 1 0 0 1 1 1 1 Putative bacterial lipoprotein (DUF799) DUF5470 PF17564.2 ORX72234.1 - 0.089 13.0 1.6 8.2 6.7 0.1 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5470) CUE PF02845.16 ORX72235.1 - 1.2e-05 24.9 0.0 3.6e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 CUE domain DUF2508 PF10704.9 ORX72235.1 - 0.042 14.0 1.4 0.059 13.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Glutaredoxin PF00462.24 ORX72236.1 - 3.1e-20 72.1 0.1 1.4e-16 60.5 0.0 2.8 2 1 1 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 ORX72236.1 - 8.2e-14 51.4 0.1 1.6e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ORX72236.1 - 0.00022 21.5 0.1 0.025 14.9 0.0 2.7 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ORX72236.1 - 0.00069 19.6 1.1 0.0075 16.3 0.1 2.7 2 1 1 3 3 3 1 Thioredoxin domain Thioredoxin_2 PF13098.6 ORX72236.1 - 0.0052 17.2 0.1 0.042 14.3 0.0 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.16 ORX72236.1 - 0.013 14.4 0.1 0.021 13.8 0.1 1.3 1 0 0 1 1 1 0 Phosducin GST_N_3 PF13417.6 ORX72236.1 - 0.014 15.8 0.0 0.026 14.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain HyaE PF07449.11 ORX72236.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE SH3BGR PF04908.15 ORX72236.1 - 0.031 14.4 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein CSN8_PSD8_EIF3K PF10075.9 ORX72237.1 - 2.4e-29 102.1 0.0 3.5e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 ORX72237.1 - 3e-05 23.5 0.0 4.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP family F-box-like PF12937.7 ORX72238.1 - 0.036 13.9 0.1 0.095 12.6 0.1 1.7 1 0 0 1 1 1 0 F-box-like Borrelia_lipo_1 PF05714.11 ORX72238.1 - 0.057 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Peptidase_M3 PF01432.20 ORX72239.1 - 2.1e-108 363.6 0.0 2.6e-108 363.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 OsmC PF02566.19 ORX72243.1 - 5.3e-06 26.8 0.0 9.5e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 OsmC-like protein COPI_C PF06957.11 ORX72244.1 - 2.2e-121 405.4 0.6 2.8e-121 405.1 0.6 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 ORX72244.1 - 2.8e-105 352.9 0.1 3.1e-104 349.5 0.0 2.5 2 1 1 3 3 3 1 Coatomer WD associated region WD40 PF00400.32 ORX72244.1 - 4.6e-44 147.5 6.7 1.3e-06 29.0 0.0 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72244.1 - 3.8e-12 46.3 0.7 0.00032 20.9 0.0 6.3 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX72244.1 - 0.0009 18.0 10.7 0.16 10.6 0.1 4.3 2 1 2 4 4 4 3 Nucleoporin Nup120/160 SGL PF08450.12 ORX72244.1 - 0.014 15.0 0.1 0.59 9.7 0.0 2.8 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region eIF3_subunit PF08597.10 ORX72244.1 - 0.067 13.1 4.3 0.12 12.2 4.3 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SNAPc_SNAP43 PF09808.9 ORX72244.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 TPR_14 PF13428.6 ORX72244.1 - 0.17 12.8 5.1 11 7.2 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Thiolase_N PF00108.23 ORX72245.1 - 6.2e-94 314.2 2.5 8e-94 313.8 2.5 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX72245.1 - 7.7e-40 135.4 0.6 7.7e-40 135.4 0.6 2.2 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX72245.1 - 2.2e-06 27.4 1.3 5.6e-06 26.1 1.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ORX72245.1 - 3.7 7.5 7.4 6.4 6.7 0.0 3.5 3 1 1 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Peptidase_S8 PF00082.22 ORX72248.1 - 4.1e-51 174.0 3.4 6.6e-51 173.3 3.4 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX72248.1 - 2.4e-15 56.3 2.0 2.7e-15 56.2 0.4 2.0 2 0 0 2 2 2 1 PA domain Cornichon PF03311.14 ORX72250.1 - 1.3e-35 122.4 17.6 3.2e-35 121.1 17.6 1.6 1 1 0 1 1 1 1 Cornichon protein CTP_transf_1 PF01148.20 ORX72250.1 - 0.42 10.3 8.6 0.52 10.0 8.6 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family DUF898 PF05987.13 ORX72250.1 - 1.2 8.2 9.2 1.4 7.9 9.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) TIMELESS PF04821.14 ORX72251.1 - 1e-42 146.3 2.2 1.4e-41 142.6 0.0 3.6 3 2 1 4 4 4 1 Timeless protein Cofilin_ADF PF00241.20 ORX72252.1 - 5e-24 84.4 0.1 5.6e-24 84.3 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SNRNP27 PF08648.12 ORX72253.1 - 9.1e-31 105.7 2.9 1.1e-30 105.4 2.9 1.1 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Histone_H2A_C PF16211.5 ORX72254.1 - 3.3e-20 71.5 1.5 6.4e-20 70.6 1.5 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ORX72254.1 - 1.7e-16 60.8 0.0 2.2e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX72254.1 - 4.2e-05 23.8 0.0 5.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX72255.1 - 1e-22 80.9 0.1 1.2e-22 80.7 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX72255.1 - 9.2e-07 29.1 0.1 9.2e-07 29.1 0.1 1.7 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ORX72255.1 - 0.0005 20.5 0.0 0.00074 20.0 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 ORX72255.1 - 0.02 14.9 0.1 0.023 14.7 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein CENP-W PF15510.6 ORX72255.1 - 0.031 14.5 0.0 0.042 14.1 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein ELO PF01151.18 ORX72257.1 - 4.4e-63 213.1 24.5 4.9e-63 213.0 24.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family UPF0113_N PF17833.1 ORX72258.1 - 4.2e-34 117.0 0.1 6.1e-34 116.4 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 ORX72258.1 - 1e-25 89.8 0.0 1.7e-25 89.0 0.0 1.4 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 ORX72258.1 - 0.095 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 PUA domain Ribosomal_L27A PF00828.19 ORX72259.1 - 4.8e-21 75.8 0.4 6.1e-21 75.4 0.4 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Lyase_8_N PF08124.11 ORX72259.1 - 0.096 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain Sec2p PF06428.11 ORX72260.1 - 3.1e-16 59.1 10.8 3.1e-16 59.1 10.8 2.2 2 1 1 3 3 3 1 GDP/GTP exchange factor Sec2p SlyX PF04102.12 ORX72260.1 - 0.00015 22.3 5.2 0.0075 16.9 0.4 4.0 2 1 3 5 5 5 2 SlyX V_ATPase_I PF01496.19 ORX72260.1 - 0.0025 15.8 1.4 0.0039 15.2 1.4 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Atg14 PF10186.9 ORX72260.1 - 0.39 9.8 10.0 3.3 6.7 4.1 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4404 PF14357.6 ORX72260.1 - 0.46 11.1 7.2 1.1 9.9 3.3 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) GAS PF13851.6 ORX72260.1 - 1 8.6 17.2 0.086 12.2 9.7 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 ORX72260.1 - 1.2 9.6 3.6 12 6.4 0.9 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 ORX72260.1 - 1.2 9.5 11.5 3.3 8.1 8.1 2.4 2 0 0 2 2 2 0 Fez1 Nup54 PF13874.6 ORX72260.1 - 7.7 6.6 9.4 69 3.5 9.4 2.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Exonuc_VII_L PF02601.15 ORX72260.1 - 9.4 5.7 10.2 38 3.7 10.2 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Polysacc_synt_4 PF04669.13 ORX72261.1 - 4.5e-21 75.3 1.1 5.7e-19 68.4 1.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis TPR_6 PF13174.6 ORX72261.1 - 0.27 12.0 1.1 1.5 9.6 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat MoaE PF02391.17 ORX72262.1 - 1.1e-23 83.7 0.4 1.4e-23 83.3 0.4 1.1 1 0 0 1 1 1 1 MoaE protein Sulfate_transp PF00916.20 ORX72263.1 - 4.1e-83 279.2 17.5 4.6e-82 275.8 15.4 2.3 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX72263.1 - 2.5e-18 65.8 0.0 4.1e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ORX72263.1 - 0.0025 18.1 0.1 0.011 16.1 0.1 2.2 1 0 0 1 1 1 1 STAS domain PgpA PF04608.13 ORX72263.1 - 0.047 13.7 0.1 0.047 13.7 0.1 2.4 2 1 0 2 2 2 0 Phosphatidylglycerophosphatase A GTP_EFTU PF00009.27 ORX72264.1 - 1.4e-36 125.9 4.5 6.8e-35 120.4 4.5 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ORX72264.1 - 1.3e-30 105.6 2.5 4.8e-30 103.8 2.5 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ORX72264.1 - 7.9e-12 45.3 0.1 2e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ORX72264.1 - 1.8e-05 24.3 0.0 4.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 ORX72264.1 - 2.1e-05 24.1 0.2 6.3e-05 22.6 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B IF2_N PF04760.15 ORX72264.1 - 9.6e-05 22.1 0.2 0.00044 20.0 0.1 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region RsgA_GTPase PF03193.16 ORX72264.1 - 0.00021 21.3 4.2 0.058 13.3 0.0 2.9 2 1 1 3 3 3 2 RsgA GTPase SRPRB PF09439.10 ORX72264.1 - 0.00099 18.6 0.1 0.00099 18.6 0.1 2.0 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ORX72264.1 - 0.0097 16.1 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 ORX72264.1 - 0.012 15.4 0.4 0.041 13.6 0.4 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D2 PF03144.25 ORX72264.1 - 0.012 16.0 3.8 1.1 9.6 0.7 3.1 2 0 0 2 2 2 0 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ORX72264.1 - 0.022 14.7 0.9 0.022 14.7 0.9 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 DraK_HK_N PF18092.1 ORX72264.1 - 0.037 14.4 0.5 0.037 14.4 0.5 2.8 3 0 0 3 3 3 0 DraK Histidine Kinase N-terminal domain Dynamin_N PF00350.23 ORX72264.1 - 2.5 8.1 5.6 5.2 7.1 0.0 3.5 3 1 1 4 4 4 0 Dynamin family Histone PF00125.24 ORX72265.1 - 7.2e-23 81.4 0.1 8.1e-23 81.2 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX72265.1 - 6.8e-07 29.5 0.1 6.8e-07 29.5 0.1 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ORX72265.1 - 0.00039 20.9 0.0 0.00054 20.4 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 ORX72265.1 - 0.017 15.2 0.1 0.02 14.9 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein CENP-W PF15510.6 ORX72265.1 - 0.023 14.9 0.0 0.029 14.6 0.0 1.1 1 0 0 1 1 1 0 CENP-W protein Histone_H2A_C PF16211.5 ORX72266.1 - 2.1e-20 72.2 1.5 4.1e-20 71.2 1.5 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ORX72266.1 - 0.011 16.0 0.0 0.017 15.5 0.0 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Herpes_UL49_2 PF04823.12 ORX72266.1 - 0.14 12.3 0.2 0.29 11.2 0.2 1.6 1 1 0 1 1 1 0 Herpesvirus UL49 tegument protein CBFD_NFYB_HMF PF00808.23 ORX72266.1 - 0.22 11.9 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SANTA PF09133.10 ORX72267.1 - 1.5e-14 54.3 0.0 2.6e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 SANTA (SANT Associated) Retrotrans_gag PF03732.17 ORX72269.1 - 0.0033 17.7 0.1 0.0085 16.3 0.1 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein 5_nucleotid PF05761.14 ORX72269.1 - 0.075 11.9 0.1 0.3 9.9 0.0 1.8 2 0 0 2 2 2 0 5' nucleotidase family zf-CCHC PF00098.23 ORX72269.1 - 0.16 12.1 1.6 0.26 11.5 1.6 1.3 1 0 0 1 1 1 0 Zinc knuckle dUTPase PF00692.19 ORX72270.1 - 4e-29 100.9 0.0 5.3e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 dUTPase Glyco_hydro_61 PF03443.14 ORX72271.1 - 0.00081 19.4 0.1 0.0015 18.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 ORX72271.1 - 0.0058 17.3 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading CBM_19 PF03427.13 ORX72271.1 - 0.22 11.5 14.6 0.092 12.7 11.2 2.2 2 1 0 2 2 2 0 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX72271.1 - 1.3 9.2 4.7 1 9.6 3.1 1.7 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain Cyt-b5 PF00173.28 ORX72272.1 - 2.9e-15 56.2 0.0 4.7e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Peptidase_M20 PF01546.28 ORX72273.1 - 8.8e-30 103.9 0.1 1.3e-29 103.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ORX72273.1 - 2.9e-15 56.1 0.0 5.2e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ORX72273.1 - 0.065 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Cnd1 PF12717.7 ORX72274.1 - 1.3e-49 168.4 1.0 5.5e-47 159.8 0.3 2.9 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 ORX72274.1 - 6.1e-26 91.2 0.0 2e-25 89.6 0.0 2.0 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 ORX72274.1 - 5.6e-08 32.4 2.9 0.4 11.1 0.0 7.0 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ORX72274.1 - 9.6e-08 32.3 2.6 0.055 13.9 0.0 6.0 5 2 2 7 7 7 3 HEAT repeats Adaptin_N PF01602.20 ORX72274.1 - 0.00012 20.8 0.1 0.017 13.7 0.1 3.4 3 1 0 3 3 3 1 Adaptin N terminal region CLASP_N PF12348.8 ORX72274.1 - 0.00026 20.6 0.1 0.015 14.9 0.0 2.5 2 0 0 2 2 2 1 CLASP N terminal GST_C PF00043.25 ORX72274.1 - 0.002 18.3 0.4 0.85 9.9 0.0 3.5 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain HEAT_EZ PF13513.6 ORX72274.1 - 0.015 15.8 4.6 10 6.7 0.0 5.3 5 0 0 5 5 5 0 HEAT-like repeat RTP1_C1 PF10363.9 ORX72274.1 - 0.02 15.1 0.1 18 5.5 0.0 3.5 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 ORX72274.1 - 0.036 13.3 0.9 0.1 11.7 0.9 1.8 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain 2-oxoacid_dh PF00198.23 ORX72275.1 - 4.7e-84 281.5 0.3 6e-84 281.1 0.3 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX72275.1 - 2.2e-17 62.6 1.7 5e-17 61.5 1.7 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 ORX72275.1 - 0.00083 20.0 1.8 0.21 12.3 0.1 2.6 2 0 0 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 ORX72275.1 - 0.0017 18.2 0.2 0.0036 17.2 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.6 ORX72275.1 - 0.02 14.7 0.8 0.063 13.1 0.1 2.1 1 1 1 2 2 2 0 Biotin-lipoyl like DEC-1_N PF04625.13 ORX72275.1 - 0.039 13.0 10.6 0.072 12.1 10.6 1.5 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region HlyD_D23 PF16576.5 ORX72275.1 - 0.041 13.1 0.4 0.13 11.5 0.1 1.9 2 1 0 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Med3 PF11593.8 ORX72275.1 - 0.42 9.7 8.9 0.66 9.1 8.9 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FAP PF07174.11 ORX72275.1 - 1.4 8.3 21.2 2.2 7.7 21.2 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DNA_pol3_delta2 PF13177.6 ORX72276.1 - 6.8e-11 42.2 0.2 1.5e-10 41.1 0.0 1.7 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 ORX72276.1 - 2.9e-06 27.7 0.0 7.1e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 ORX72276.1 - 1.6e-05 25.2 1.0 2.9e-05 24.4 0.3 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain Rad17 PF03215.15 ORX72276.1 - 5.4e-05 23.2 0.0 0.0007 19.6 0.0 2.2 2 1 0 2 2 2 1 Rad17 P-loop domain T2SSE PF00437.20 ORX72276.1 - 0.0011 18.1 0.9 0.0047 16.0 0.0 2.3 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_22 PF13401.6 ORX72276.1 - 0.0011 19.2 0.4 0.0095 16.2 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 ORX72276.1 - 0.0038 17.6 1.4 0.015 15.7 0.2 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX72276.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) HTH_Tnp_Mu_2 PF09039.11 ORX72276.1 - 0.11 12.6 0.2 22 5.2 0.0 2.8 3 0 0 3 3 3 0 Mu DNA binding, I gamma subdomain AAA_24 PF13479.6 ORX72276.1 - 0.19 11.4 0.2 0.76 9.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain Rab3-GTPase_cat PF13890.6 ORX72277.1 - 1.1e-52 178.0 0.1 2.1e-52 177.1 0.1 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit IPPT PF01715.17 ORX72278.1 - 4.8e-56 190.1 0.1 4.8e-56 190.1 0.1 1.3 2 0 0 2 2 2 1 IPP transferase IPT PF01745.16 ORX72278.1 - 0.00048 19.6 0.0 0.0014 18.1 0.0 1.8 2 0 0 2 2 2 1 Isopentenyl transferase AAA_18 PF13238.6 ORX72278.1 - 0.0011 19.5 0.3 0.021 15.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX72278.1 - 0.0072 16.5 5.3 0.031 14.4 1.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX72278.1 - 0.017 15.5 0.3 0.048 14.0 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ORX72278.1 - 0.045 13.3 0.7 0.25 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ORX72278.1 - 0.086 13.1 0.6 0.34 11.2 0.2 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX72278.1 - 0.096 13.1 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 ORX72278.1 - 0.099 12.6 0.2 0.51 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Hpr_kinase_C PF07475.12 ORX72278.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain NACHT PF05729.12 ORX72278.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain zf-C2H2_jaz PF12171.8 ORX72278.1 - 0.26 11.6 0.1 0.26 11.6 0.1 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX72278.1 - 0.31 11.5 1.3 0.8 10.2 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Cytidylate_kin PF02224.18 ORX72278.1 - 0.37 10.5 0.1 0.37 10.5 0.1 2.2 3 1 0 3 3 3 0 Cytidylate kinase DUF883 PF05957.13 ORX72278.1 - 0.81 10.3 5.4 0.2 12.3 1.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF87 PF01935.17 ORX72278.1 - 1.3 9.0 4.4 1.2 9.2 0.1 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain zf-CCCH PF00642.24 ORX72279.1 - 4.2e-18 64.8 12.7 1.8e-09 37.3 2.1 2.1 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX72279.1 - 6.2e-12 45.1 8.3 1.6e-06 27.9 1.0 2.2 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ORX72279.1 - 1.9e-09 37.1 8.3 0.00015 21.5 0.6 2.2 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX72279.1 - 6.5e-05 23.2 6.8 0.048 14.1 0.8 2.3 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX72279.1 - 0.0062 17.2 7.2 0.097 13.4 0.8 2.0 1 1 1 2 2 2 2 Torus domain Lustrin_cystein PF14625.6 ORX72279.1 - 0.0064 16.9 5.3 0.31 11.4 0.7 2.1 1 1 1 2 2 2 2 Lustrin, cysteine-rich repeated domain Nab2p_Zf1 PF18260.1 ORX72279.1 - 0.016 15.1 1.2 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf-CCHH PF10283.9 ORX72279.1 - 0.23 11.5 10.9 2.7 8.0 1.5 2.7 2 0 0 2 2 2 0 PBZ domain Opy2 PF09463.10 ORX72279.1 - 0.31 11.4 3.6 6.8 7.1 0.5 2.5 2 1 0 2 2 2 0 Opy2 protein CLIP_SPH_mas PF18398.1 ORX72279.1 - 1.3 9.5 5.2 6.2 7.3 0.7 2.1 2 0 0 2 2 2 0 Clip-domain serine protease homolog masquerade ADH_zinc_N PF00107.26 ORX72281.1 - 1.4e-26 93.0 0.1 2.3e-26 92.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX72281.1 - 9.5e-17 62.3 0.0 1.6e-16 61.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX72281.1 - 5.2e-09 35.9 0.0 3.5e-08 33.3 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ORX72281.1 - 7.8e-06 25.7 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Complex1_LYR PF05347.15 ORX72282.1 - 4.7e-12 45.8 0.1 6.3e-12 45.4 0.1 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX72282.1 - 0.001 19.8 0.2 0.0012 19.6 0.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Afi1 PF07792.12 ORX72283.1 - 7.1e-26 91.3 0.0 6.4e-21 75.2 0.0 2.6 1 1 1 2 2 2 2 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 ORX72283.1 - 4.7e-24 84.5 0.0 2.8e-23 82.1 0.0 2.1 1 1 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 ORX72283.1 - 4.3e-05 22.4 0.0 0.00062 18.6 0.0 2.3 2 1 0 2 2 2 1 Transport protein Avl9 Citrus_P18 PF05520.11 ORX72283.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Citrus tristeza virus P18 protein Cyt-b5 PF00173.28 ORX72284.1 - 2e-10 40.6 0.0 2.3e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Yae1_N PF09811.9 ORX72285.1 - 0.00063 19.4 0.5 0.0011 18.6 0.5 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal UL42 PF17638.2 ORX72288.1 - 1.3 9.0 8.1 1.3 9.0 8.1 1.2 1 0 0 1 1 1 0 HCMV UL42 HAD_2 PF13419.6 ORX72289.1 - 5.3e-14 52.7 0.0 5.8e-14 52.6 0.0 1.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX72289.1 - 8.8e-10 39.2 0.0 1.7e-09 38.3 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX72289.1 - 2.1e-05 24.5 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DUF5353 PF17304.2 ORX72289.1 - 0.11 12.3 0.9 0.91 9.3 0.1 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5353) DHO_dh PF01180.21 ORX72290.1 - 9.5e-75 251.5 0.1 1.5e-74 250.9 0.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 ORX72290.1 - 0.086 12.2 1.5 0.15 11.4 1.5 1.5 1 1 0 1 1 1 0 Nitronate monooxygenase Chitin_synth_2 PF03142.15 ORX72291.1 - 8e-29 100.6 0.0 5.9e-28 97.8 0.0 2.0 1 1 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 ORX72291.1 - 0.00053 20.1 0.1 0.25 11.5 0.0 3.2 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 ORX72291.1 - 0.0039 17.0 0.0 0.38 10.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 RsfS PF02410.15 ORX72292.1 - 1.1e-21 77.0 0.1 1.9e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation OrsD PF12013.8 ORX72293.1 - 3.7e-06 27.4 0.6 9.4e-05 22.8 0.0 2.6 2 1 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2 PF00096.26 ORX72293.1 - 2.4e-05 24.5 11.4 0.0042 17.5 3.8 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX72293.1 - 0.00039 21.0 18.1 0.0053 17.5 3.2 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX72293.1 - 0.02 15.2 2.8 0.02 15.2 2.8 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zap1_zf2 PF18217.1 ORX72293.1 - 0.13 12.3 0.8 0.35 10.9 0.8 1.8 1 0 0 1 1 1 0 Zap1 zinc finger 2 Actin_micro PF17003.5 ORX72293.1 - 0.19 10.9 0.5 13 4.9 0.1 2.1 2 0 0 2 2 2 0 Putative actin-like family tRNA_Me_trans PF03054.16 ORX72294.1 - 4.5e-107 357.9 0.0 5.1e-94 315.0 0.0 2.0 1 1 1 2 2 2 2 tRNA methyl transferase ThiI PF02568.14 ORX72294.1 - 0.0048 16.5 0.0 0.011 15.3 0.0 1.6 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.17 ORX72294.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Asn_synthase PF00733.21 ORX72294.1 - 0.083 12.5 0.0 0.098 12.3 0.0 1.4 1 1 0 1 1 1 0 Asparagine synthase QueC PF06508.13 ORX72294.1 - 0.16 11.4 0.0 0.5 9.8 0.0 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Peptidase_M16_M PF16187.5 ORX72295.1 - 3.3e-67 226.7 0.1 9.3e-67 225.3 0.0 1.7 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ORX72295.1 - 9.8e-27 93.8 0.0 4.8e-26 91.5 0.1 2.2 2 1 1 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX72295.1 - 1.4e-25 90.3 0.0 1.9e-14 54.1 0.0 4.4 4 0 0 4 4 4 3 Peptidase M16 inactive domain zf-C2H2 PF00096.26 ORX72297.1 - 1e-11 44.6 18.2 1.2e-05 25.5 4.2 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX72297.1 - 4e-08 33.3 21.1 8e-05 22.9 4.8 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX72297.1 - 1.3e-07 31.8 15.1 0.00055 20.5 3.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX72297.1 - 2.7e-06 27.6 6.0 3.1e-05 24.2 1.4 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX72297.1 - 0.00068 19.3 12.8 0.013 15.2 2.4 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 ORX72297.1 - 0.0068 16.1 12.8 0.011 15.4 1.5 3.4 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 ORX72297.1 - 0.011 15.7 2.2 0.011 15.7 2.2 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX72297.1 - 0.015 15.6 2.3 0.015 15.6 2.3 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 ORX72297.1 - 0.044 13.4 0.4 0.044 13.4 0.4 2.1 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_2 PF12756.7 ORX72297.1 - 0.093 13.1 7.5 0.75 10.2 0.7 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 ORX72297.1 - 0.1 12.5 5.9 0.26 11.2 1.4 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Memo PF01875.17 ORX72299.1 - 2e-77 260.0 0.0 2.2e-77 259.8 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein ATP-synt_G PF04718.15 ORX72300.1 - 1.1e-15 58.3 0.5 1.6e-15 57.7 0.2 1.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit ColG_sub PF18496.1 ORX72300.1 - 0.013 15.7 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Collagenase G catalytic helper subdomain DAHP_synth_1 PF00793.20 ORX72301.1 - 1e-98 329.6 0.0 1.3e-98 329.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family CLASP_N PF12348.8 ORX72305.1 - 1.5e-11 44.4 0.0 1.7e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 CLASP N terminal DUF3739 PF12545.8 ORX72305.1 - 0.11 12.9 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 Filamentous haemagglutinin family outer membrane protein Neuraminidase PF18413.1 ORX72305.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Neuraminidase-like domain NAD_binding_10 PF13460.6 ORX72307.1 - 7.5e-11 42.3 0.0 1e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX72307.1 - 0.00019 21.0 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ORX72307.1 - 0.0034 17.8 0.0 0.0054 17.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 ORX72307.1 - 0.0098 15.5 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.20 ORX72307.1 - 0.08 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 ORX72307.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 ORX72307.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 ORX72307.1 - 0.14 11.2 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HrpB7 PF09486.10 ORX72310.1 - 0.052 13.9 0.0 0.061 13.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF3989 PF13150.6 ORX72310.1 - 0.075 12.8 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) RNB PF00773.19 ORX72311.1 - 2.4e-103 345.9 0.1 3.5e-103 345.4 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 ORX72311.1 - 4.1e-20 72.0 0.0 7.5e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 ORX72311.1 - 1.6e-19 69.7 0.0 3.3e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 ORX72311.1 - 2.7e-15 56.1 0.1 6.3e-15 54.9 0.1 1.6 1 0 0 1 1 1 1 S1 domain PIN_4 PF13638.6 ORX72311.1 - 8.4e-11 42.3 0.1 2.9e-10 40.5 0.1 2.0 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 ORX72311.1 - 3.9e-09 36.5 0.0 2.5e-07 30.8 0.0 2.8 2 0 0 2 2 2 1 Cold shock domain OB_RNB PF08206.11 ORX72311.1 - 0.0024 17.5 0.0 0.009 15.7 0.0 2.0 1 0 0 1 1 1 1 Ribonuclease B OB domain Dis3l2_C_term PF17877.1 ORX72311.1 - 0.007 16.7 0.1 0.007 16.7 0.1 1.9 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal ATP19 PF11022.8 ORX72312.1 - 8.5e-19 67.7 0.1 9.9e-19 67.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K PIG-H PF10181.9 ORX72313.1 - 1.6e-14 53.5 0.1 2.8e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component E1-E2_ATPase PF00122.20 ORX72314.1 - 6.8e-05 22.5 0.3 6.8e-05 22.5 0.3 3.2 3 1 0 3 3 3 1 E1-E2 ATPase DUF1129 PF06570.11 ORX72314.1 - 0.018 14.5 1.3 0.041 13.4 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2043 PF09740.9 ORX72315.1 - 9.3e-28 97.0 0.1 1.9e-27 96.0 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) DUF4637 PF15470.6 ORX72315.1 - 0.06 13.1 0.3 0.06 13.1 0.3 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4637) EFTUD2 PF16004.5 ORX72315.1 - 0.097 13.3 2.1 0.46 11.1 0.3 2.7 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus CBM_19 PF03427.13 ORX72316.1 - 0.0093 15.9 3.8 0.0093 15.9 3.8 2.8 3 0 0 3 3 3 1 Carbohydrate binding domain (family 19) Glyoxalase PF00903.25 ORX72317.1 - 3.8e-24 85.3 0.3 4.5e-24 85.1 0.3 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ORX72317.1 - 1.1e-08 35.8 0.0 1.7e-08 35.2 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ORX72317.1 - 4.4e-08 33.4 0.0 1.2e-07 31.9 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ORX72317.1 - 0.00026 20.9 0.0 0.4 10.6 0.0 2.3 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 ORX72317.1 - 0.019 15.1 0.0 0.046 13.8 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain CHAP PF05257.16 ORX72317.1 - 0.026 15.1 0.4 3.3 8.3 0.6 2.2 1 1 1 2 2 2 0 CHAP domain CppA_N PF14506.6 ORX72317.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 CppA N-terminal KAR9 PF08580.10 ORX72318.1 - 1.8 7.0 9.4 2 6.8 9.4 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 SPX PF03105.19 ORX72318.1 - 4.2 7.2 6.2 4.8 7.0 6.2 1.1 1 0 0 1 1 1 0 SPX domain MCM PF00493.23 ORX72320.1 - 2.5e-76 255.7 0.0 4.2e-76 254.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX72320.1 - 1.8e-19 69.8 0.8 4.3e-19 68.6 0.8 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX72320.1 - 3.4e-16 59.4 3.7 7.2e-16 58.4 3.7 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ORX72320.1 - 9.4e-09 34.9 0.4 2.5e-05 23.7 0.1 3.0 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX72320.1 - 5.3e-07 29.7 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ORX72320.1 - 0.00012 21.9 0.0 0.00033 20.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 ORX72320.1 - 0.0055 17.3 0.1 0.012 16.2 0.1 1.5 1 0 0 1 1 1 1 MCM N-terminal domain OEP PF02321.18 ORX72320.1 - 0.066 13.0 5.0 0.11 12.2 5.0 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein Sigma54_activat PF00158.26 ORX72320.1 - 0.1 12.3 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 ORX72320.1 - 0.11 12.2 0.3 0.42 10.3 0.3 1.8 1 1 0 1 1 1 0 AAA domain SWIRM PF04433.17 ORX72322.1 - 9.2e-11 41.9 0.0 1.7e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Tcp11 PF05794.13 ORX72323.1 - 1.2e-54 186.1 2.9 2.1e-54 185.3 2.9 1.4 1 0 0 1 1 1 1 T-complex protein 11 Rav1p_C PF12234.8 ORX72323.1 - 0.0073 14.8 0.4 0.12 10.8 0.1 2.1 2 0 0 2 2 2 1 RAVE protein 1 C terminal Arabinose_Isome PF02610.15 ORX72323.1 - 0.041 13.1 0.8 0.08 12.1 0.2 1.7 2 0 0 2 2 2 0 L-arabinose isomerase IQ PF00612.27 ORX72323.1 - 0.64 10.0 3.8 0.71 9.8 1.3 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif Sugar_tr PF00083.24 ORX72324.1 - 1.1e-81 275.1 39.0 1.3e-62 212.1 20.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX72324.1 - 4.2e-30 104.9 32.4 4.2e-30 104.9 32.4 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily PSI PF01437.25 ORX72324.1 - 6.1e-05 23.5 3.4 0.00013 22.4 3.4 1.5 1 0 0 1 1 1 1 Plexin repeat UL42 PF17638.2 ORX72324.1 - 0.065 13.2 0.4 0.065 13.2 0.4 2.5 3 0 0 3 3 3 0 HCMV UL42 Wzy_C PF04932.15 ORX72324.1 - 4.6 6.9 19.7 1.4 8.5 0.0 3.9 4 1 0 4 4 4 0 O-Antigen ligase Phage_holin_3_2 PF04550.12 ORX72324.1 - 7 7.3 9.3 1.9 9.1 3.5 2.8 2 1 1 3 3 3 0 Phage holin family 2 Transthyretin PF00576.21 ORX72325.1 - 8.7e-36 123.0 0.0 9.7e-36 122.8 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family Transthyretin PF00576.21 ORX72326.1 - 4.8e-22 78.7 0.8 1e-19 71.2 0.8 2.1 1 1 0 1 1 1 1 HIUase/Transthyretin family Big_1 PF02369.16 ORX72326.1 - 0.0078 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.6 ORX72326.1 - 0.0081 16.4 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Transthyretin PF00576.21 ORX72327.1 - 4.3e-32 111.1 0.0 5e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Nbl1_Borealin_N PF10444.9 ORX72328.1 - 5.4e-11 42.0 1.7 8.2e-11 41.4 1.7 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal PCI PF01399.27 ORX72329.1 - 2.1e-05 25.0 0.5 4.4e-05 23.9 0.5 1.6 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 ORX72329.1 - 0.0096 15.8 0.1 0.019 14.8 0.1 1.5 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PUF PF00806.19 ORX72330.1 - 1.8e-15 55.7 0.0 0.018 14.7 0.0 7.6 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat Kinesin PF00225.23 ORX72332.1 - 3.3e-93 312.3 0.0 4.5e-93 311.8 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX72332.1 - 8.5e-17 61.5 0.0 2.9e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding ResIII PF04851.15 ORX72332.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Importin_rep_4 PF18808.1 ORX72332.1 - 1 9.7 6.7 2.2 8.6 4.4 2.5 3 0 0 3 3 3 0 Importin repeat 2_5_RNA_ligase2 PF13563.6 ORX72333.1 - 0.081 12.8 0.3 4.7 7.1 0.0 2.3 1 1 0 2 2 2 0 2'-5' RNA ligase superfamily RNR_N PF08343.10 ORX72333.1 - 0.16 12.0 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Ribonucleotide reductase N-terminal SAM_2 PF07647.17 ORX72334.1 - 3.5e-08 33.4 0.2 3.3e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX72334.1 - 0.00056 20.3 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Metallophos PF00149.28 ORX72335.1 - 1.3e-39 136.9 0.2 1.6e-39 136.5 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX72335.1 - 1.3e-21 76.8 0.5 2.4e-21 75.9 0.5 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Importin_rep PF18773.1 ORX72335.1 - 0.043 13.5 0.1 0.87 9.3 0.0 2.5 2 0 0 2 2 2 0 Importin 13 repeat Herpes_UL31 PF02718.14 ORX72336.1 - 0.028 13.4 0.3 0.037 13.0 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus UL31-like protein FAA_hydrolase PF01557.18 ORX72338.1 - 2.2e-55 187.7 0.0 5.3e-55 186.4 0.0 1.6 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ORX72338.1 - 1.4e-30 105.6 0.0 2.9e-30 104.6 0.0 1.6 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal BCDHK_Adom3 PF10436.9 ORX72338.1 - 3.8e-12 46.3 0.1 4.2e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX72338.1 - 9.6e-11 42.2 0.0 2e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX72338.1 - 0.0055 16.5 0.0 0.013 15.3 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Notch PF00066.17 ORX72338.1 - 0.14 12.7 0.6 0.29 11.6 0.6 1.5 1 0 0 1 1 1 0 LNR domain Malate_DH PF12434.8 ORX72338.1 - 1 9.4 0.0 1 9.4 0.0 2.4 3 0 0 3 3 3 0 Malate dehydrogenase enzyme CX9C PF16860.5 ORX72339.1 - 3.1e-17 62.3 9.7 1e-11 44.6 1.8 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ORX72339.1 - 2.9e-07 30.4 4.9 0.0058 16.7 0.3 2.9 2 1 1 3 3 3 3 CHCH domain Cmc1 PF08583.10 ORX72339.1 - 5e-06 26.4 9.3 0.0012 18.8 1.9 3.1 1 1 2 3 3 3 2 Cytochrome c oxidase biogenesis protein Cmc1 like MTCP1 PF08991.10 ORX72339.1 - 0.00029 21.0 1.5 0.00029 21.0 1.5 2.3 2 1 0 2 2 2 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 ORX72339.1 - 0.00072 19.8 9.4 0.16 12.3 5.3 2.9 1 1 2 3 3 3 3 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.17 ORX72339.1 - 0.002 18.3 7.4 0.35 11.1 0.8 3.0 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb COX17 PF05051.13 ORX72339.1 - 0.0052 17.1 8.9 0.21 12.0 1.5 3.0 1 1 2 3 3 3 2 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.16 ORX72339.1 - 0.0069 16.6 10.0 0.13 12.4 0.4 2.5 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein ALMT PF11744.8 ORX72339.1 - 0.018 13.9 0.9 0.026 13.3 0.9 1.3 1 1 0 1 1 1 0 Aluminium activated malate transporter UPF0203 PF05254.12 ORX72339.1 - 0.034 14.4 6.9 5.5 7.3 5.2 2.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) NDUF_B7 PF05676.13 ORX72339.1 - 0.16 11.7 7.4 2.3 8.0 1.1 2.2 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GCK PF07802.11 ORX72339.1 - 0.17 12.3 8.7 0.24 11.8 1.7 2.9 1 1 2 3 3 3 0 GCK domain DB PF01682.19 ORX72339.1 - 0.49 10.7 9.1 0.57 10.5 6.9 1.9 1 1 1 2 2 2 0 DB module Glyco_hydro_46 PF01374.18 ORX72341.1 - 4.2e-45 154.0 3.3 1.5e-44 152.1 3.3 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 Pirin_C PF05726.13 ORX72342.1 - 1.7e-23 83.0 0.0 3e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX72342.1 - 5.3e-05 23.1 0.3 0.00012 22.0 0.3 1.6 1 0 0 1 1 1 1 Pirin DUF1254 PF06863.12 ORX72342.1 - 0.012 15.6 0.0 0.033 14.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1254) FAD_binding_1 PF00667.20 ORX72343.1 - 4.1e-06 26.5 0.0 4.8e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DUF2604 PF10790.9 ORX72343.1 - 0.039 14.2 0.0 0.059 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF2604) BCNT PF07572.12 ORX72343.1 - 0.18 11.9 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Bucentaur or craniofacial development p450 PF00067.22 ORX72344.1 - 3.6e-89 299.6 0.0 4.8e-89 299.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 ORX72344.1 - 3.7e-20 72.6 0.0 6.5e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX72344.1 - 0.031 14.5 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain ABC_tran PF00005.27 ORX72345.1 - 8.3e-14 52.3 0.0 1.5e-13 51.4 0.0 1.4 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX72345.1 - 0.2 11.1 0.0 0.97 8.8 0.0 1.8 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 ORX72346.1 - 8.2e-30 104.1 0.0 1.2e-29 103.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX72346.1 - 5.1e-07 29.4 0.5 0.00091 18.7 0.1 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX72346.1 - 0.00043 20.3 0.1 0.0014 18.7 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX72346.1 - 0.0013 19.1 0.1 0.002 18.6 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 ORX72346.1 - 0.002 18.3 0.7 0.0043 17.2 0.5 1.7 1 1 1 2 2 2 1 Helicase HerA, central domain AAA_21 PF13304.6 ORX72346.1 - 0.0031 17.4 0.2 0.13 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX72346.1 - 0.0077 16.5 0.2 0.032 14.5 0.2 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX72346.1 - 0.022 14.5 0.1 0.4 10.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein FKBP_N_2 PF18023.1 ORX72346.1 - 0.023 14.8 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 BDBT FKBP like N-terminal AAA_24 PF13479.6 ORX72346.1 - 0.043 13.5 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX72346.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ORX72346.1 - 0.069 12.9 0.5 0.32 10.7 0.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ORX72346.1 - 0.1 12.4 0.4 0.25 11.1 0.2 1.8 1 1 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 ORX72346.1 - 0.11 11.7 1.1 7.1 5.7 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 ORX72346.1 - 0.12 12.0 0.1 0.15 11.7 0.1 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 ORX72346.1 - 0.15 12.6 0.0 0.23 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 ORX72347.1 - 1.9e-09 38.0 6.6 0.014 16.2 0.3 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72347.1 - 0.00073 19.8 0.0 8.7 6.7 0.0 4.6 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TFIID_20kDa PF03847.13 ORX72348.1 - 1.5e-33 115.1 0.2 2e-33 114.7 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 ORX72348.1 - 9.6e-06 25.8 0.1 1.5e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX72348.1 - 0.00012 22.5 0.0 0.00019 21.8 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 ORX72348.1 - 0.00071 19.6 0.0 0.0009 19.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 ORX72348.1 - 0.071 13.2 0.0 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DNApol_Exo PF18136.1 ORX72349.1 - 2.6e-90 302.4 0.0 6.2e-90 301.2 0.0 1.6 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 ORX72349.1 - 5.8e-49 167.1 0.0 9.5e-49 166.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 ORX72349.1 - 0.043 13.5 0.0 0.2 11.4 0.0 2.1 1 1 0 1 1 1 0 3'-5' exonuclease TPR_19 PF14559.6 ORX72350.1 - 4.1e-18 65.7 22.5 5.2e-06 26.9 0.2 4.0 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72350.1 - 5.3e-14 51.7 8.6 0.0011 19.6 0.8 5.3 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX72350.1 - 4.3e-12 46.5 4.3 7.7e-05 23.3 0.2 3.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX72350.1 - 2.2e-09 36.7 9.7 0.0027 17.7 0.8 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX72350.1 - 2.9e-06 27.0 6.4 0.13 12.5 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX72350.1 - 1.6e-05 24.5 6.2 0.0044 16.8 0.4 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX72350.1 - 1.6e-05 24.9 4.1 0.18 12.2 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX72350.1 - 1.9e-05 25.0 6.7 0.84 10.4 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX72350.1 - 4.7e-05 23.5 4.0 0.038 14.2 1.1 2.7 2 2 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ORX72350.1 - 0.0001 22.4 5.3 0.013 15.6 0.6 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX72350.1 - 0.00012 22.3 1.1 0.45 10.9 0.0 3.2 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX72350.1 - 0.00042 19.9 1.4 0.15 11.7 0.0 3.3 3 1 1 4 4 4 1 TPR repeat PknG_TPR PF16918.5 ORX72350.1 - 0.0013 17.6 0.2 0.0017 17.1 0.2 1.3 1 1 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_15 PF13429.6 ORX72350.1 - 0.0052 16.0 4.5 0.0088 15.3 4.6 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat PaREP1 PF05942.11 ORX72350.1 - 0.0054 16.6 1.0 0.053 13.5 0.0 2.9 3 1 0 3 3 3 1 Archaeal PaREP1/PaREP8 family TPR_12 PF13424.6 ORX72350.1 - 0.0059 16.9 12.9 0.48 10.7 0.6 4.1 3 1 2 5 5 4 3 Tetratricopeptide repeat ChAPs PF09295.10 ORX72350.1 - 0.024 13.6 0.2 0.029 13.4 0.2 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) CotJB PF12652.7 ORX72350.1 - 0.036 14.3 1.4 0.11 12.8 0.2 2.3 2 1 1 3 3 3 0 CotJB protein DUF1028 PF06267.12 ORX72350.1 - 0.051 13.4 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF1028) AAA_3 PF07726.11 ORX72350.1 - 0.13 12.2 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PPR PF01535.20 ORX72350.1 - 0.19 12.0 0.4 7.9 7.0 0.0 3.4 4 0 0 4 4 4 0 PPR repeat PDEase_I PF00233.19 ORX72351.1 - 8.3e-60 202.5 0.2 1.2e-59 202.0 0.2 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF1265 PF06887.14 ORX72351.1 - 0.065 13.2 0.4 0.14 12.1 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) NIF PF03031.18 ORX72353.1 - 1e-52 178.1 0.2 1.3e-52 177.7 0.2 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MCM PF00493.23 ORX72354.1 - 2.1e-80 269.0 0.0 3.1e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX72354.1 - 8.5e-27 93.5 2.4 1.3e-26 92.9 1.2 1.9 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 ORX72354.1 - 4.2e-20 72.0 3.4 7.2e-20 71.2 3.4 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ORX72354.1 - 1.7e-07 30.8 0.1 3.7e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX72354.1 - 2e-06 27.7 0.0 5.8e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX72354.1 - 3.6e-06 27.0 0.0 6.5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX72354.1 - 0.02 15.3 0.2 0.078 13.4 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX72354.1 - 0.04 14.3 0.0 0.093 13.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX72354.1 - 0.13 12.0 0.1 0.32 10.7 0.1 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Pirin_C PF05726.13 ORX72355.1 - 2.9e-23 82.2 0.0 5.2e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX72355.1 - 5.2e-05 23.2 0.3 0.00012 22.0 0.3 1.7 1 0 0 1 1 1 1 Pirin DUF1254 PF06863.12 ORX72355.1 - 0.011 15.8 0.0 0.031 14.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1254) Glyco_hydro_46 PF01374.18 ORX72356.1 - 5.6e-42 143.8 0.8 7e-42 143.4 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 46 Trypan_PARP PF05887.11 ORX72358.1 - 0.0014 18.6 32.9 0.0036 17.3 15.7 2.3 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) RPE65 PF03055.15 ORX72359.1 - 7.4e-66 223.2 0.2 6.8e-65 220.1 0.2 1.9 1 1 0 1 1 1 1 Retinal pigment epithelial membrane protein PIG-F PF06699.11 ORX72360.1 - 6.9e-33 114.3 6.1 8.4e-33 114.0 6.1 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Nitrate_red_gam PF02665.14 ORX72360.1 - 0.12 12.0 3.1 0.031 13.8 0.4 1.5 2 0 0 2 2 2 0 Nitrate reductase gamma subunit Colicin_V PF02674.16 ORX72360.1 - 7.6 6.5 11.5 0.17 11.9 1.7 2.4 2 1 0 2 2 2 0 Colicin V production protein FUSC_2 PF13515.6 ORX72360.1 - 9.5 6.4 12.2 0.21 11.7 4.4 2.2 2 2 0 2 2 2 0 Fusaric acid resistance protein-like Sec23_trunk PF04811.15 ORX72361.1 - 2.5e-78 263.0 0.0 3.4e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ORX72361.1 - 6.4e-30 103.7 0.5 1.2e-29 102.9 0.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ORX72361.1 - 6.3e-25 87.0 0.2 1.2e-24 86.1 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ORX72361.1 - 6e-17 61.4 6.4 1.2e-16 60.4 6.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX72361.1 - 6.6e-12 45.2 0.0 2.5e-11 43.3 0.0 2.0 1 1 0 1 1 1 1 Gelsolin repeat REV1_C PF16727.5 ORX72361.1 - 0.021 15.2 0.1 0.057 13.8 0.0 1.7 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain HlyD_3 PF13437.6 ORX72361.1 - 0.024 15.3 0.0 0.047 14.4 0.0 1.4 1 0 0 1 1 1 0 HlyD family secretion protein Vps36-NZF-N PF16988.5 ORX72361.1 - 0.11 11.9 0.1 0.23 10.9 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Peptidase_M17 PF00883.21 ORX72362.1 - 2.1e-121 405.0 0.6 2.8e-121 404.6 0.6 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 ORX72362.1 - 1.1e-15 57.6 1.3 2.5e-15 56.4 1.3 1.7 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain ABC2_membrane PF01061.24 ORX72365.1 - 1.9e-35 122.2 27.0 1.9e-35 122.2 27.0 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ORX72365.1 - 7e-25 88.1 0.0 1.1e-24 87.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ORX72365.1 - 3.2e-07 29.8 18.2 4.7e-07 29.2 18.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 ORX72365.1 - 0.00011 22.2 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ORX72365.1 - 0.0031 17.9 0.0 0.0055 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ORX72365.1 - 0.011 15.9 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ORX72365.1 - 0.02 14.9 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ORX72365.1 - 0.021 14.4 0.0 0.049 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX72365.1 - 0.047 14.2 0.0 0.094 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ORX72365.1 - 0.051 13.4 1.4 0.5 10.1 0.5 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ORX72365.1 - 0.059 13.9 0.2 0.12 12.9 0.2 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX72365.1 - 0.094 12.6 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ORX72365.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain adh_short PF00106.25 ORX72367.1 - 1.7e-45 154.9 0.1 2.7e-45 154.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX72367.1 - 6.5e-26 91.3 0.6 1.1e-25 90.6 0.6 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX72367.1 - 9.9e-07 28.8 1.0 0.0026 17.7 0.1 2.2 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 ORX72367.1 - 0.022 14.1 0.1 0.053 12.8 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 ORX72367.1 - 0.031 13.7 0.0 0.075 12.4 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) JAB PF01398.21 ORX72370.1 - 2e-33 114.9 0.2 4.3e-33 113.8 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ORX72370.1 - 8.8e-15 55.1 0.7 1.6e-14 54.2 0.7 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ORX72370.1 - 7.8e-08 32.1 0.0 1.2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 ORX72370.1 - 0.0069 16.4 0.6 0.023 14.7 0.0 1.9 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0172) DUF5624 PF18538.1 ORX72370.1 - 0.062 13.4 0.2 0.18 11.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) C2 PF00168.30 ORX72371.1 - 3e-47 159.2 0.1 6.4e-23 81.0 0.1 2.4 2 0 0 2 2 2 2 C2 domain SMP_LBD PF17047.5 ORX72371.1 - 1.3e-07 31.2 0.0 4.5e-06 26.2 0.0 2.2 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain SGS PF05002.15 ORX72372.1 - 8.9e-31 105.8 0.2 3.8e-30 103.8 0.2 2.2 1 0 0 1 1 1 1 SGS domain CS PF04969.16 ORX72372.1 - 1.1e-14 55.2 0.3 2.4e-14 54.1 0.3 1.6 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.6 ORX72372.1 - 2.4e-05 23.9 0.1 0.0017 18.0 0.0 2.6 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 ORX72372.1 - 8.9e-05 22.3 9.4 0.0041 17.1 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX72372.1 - 0.00039 21.0 7.5 0.043 14.5 2.1 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX72372.1 - 0.00039 20.1 4.7 0.0045 16.7 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX72372.1 - 0.0084 16.6 2.7 0.28 11.7 0.0 2.8 1 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ORX72372.1 - 0.0095 16.0 12.6 0.28 11.3 0.1 3.8 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 ORX72372.1 - 0.014 15.3 0.3 0.6 10.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX72372.1 - 0.043 14.1 6.1 2.5 8.5 2.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX72372.1 - 0.045 14.0 9.6 0.17 12.2 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72372.1 - 0.099 13.5 3.1 2.5 9.2 0.0 3.2 2 2 1 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 ORX72372.1 - 0.21 11.7 0.1 0.21 11.7 0.1 3.2 3 2 1 4 4 4 0 MAS20 protein import receptor TPR_6 PF13174.6 ORX72372.1 - 0.41 11.4 4.4 4.2 8.2 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat PTS_IIA PF02255.16 ORX72372.1 - 0.43 10.7 5.2 1 9.5 0.3 2.8 3 0 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit ANAPC3 PF12895.7 ORX72372.1 - 0.69 10.2 4.7 1.1 9.6 0.5 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2057 PF09829.9 ORX72372.1 - 2.6 8.2 10.8 0.16 12.1 0.9 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) WD40 PF00400.32 ORX72373.1 - 2.7e-39 132.4 10.0 2.5e-05 24.9 0.0 11.7 12 1 1 13 13 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72373.1 - 6e-23 81.0 0.0 0.0014 18.9 0.0 9.5 5 3 4 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ORX72373.1 - 4.7e-22 78.3 0.0 7.6e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 ORX72373.1 - 2.2e-12 47.3 0.2 4.1e-05 23.5 0.2 5.1 3 2 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX72373.1 - 0.00022 20.3 1.0 0.58 9.1 0.0 4.6 3 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ORX72373.1 - 0.00034 20.5 0.6 37 4.4 0.0 5.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ORX72373.1 - 0.0039 16.5 0.0 0.012 15.0 0.0 1.8 1 0 0 1 1 1 1 WD40-like domain Cytochrom_D1 PF02239.16 ORX72373.1 - 0.0058 15.2 1.0 3.5 6.1 0.1 3.3 3 1 1 4 4 4 2 Cytochrome D1 heme domain DUF1513 PF07433.11 ORX72373.1 - 0.017 14.2 0.0 0.16 11.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) RAB3GAP2_N PF14655.6 ORX72373.1 - 0.017 14.4 0.0 0.082 12.2 0.0 2.0 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.8 ORX72373.1 - 0.031 12.9 0.0 3.9 6.0 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Lactonase PF10282.9 ORX72373.1 - 0.077 12.2 0.0 28 3.8 0.0 3.5 2 2 2 4 4 4 0 Lactonase, 7-bladed beta-propeller Proteasome_A_N PF10584.9 ORX72373.1 - 0.2 11.4 2.8 59 3.5 0.1 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Cupin_8 PF13621.6 ORX72375.1 - 4.9e-42 144.4 0.0 6e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ORX72375.1 - 2.8e-15 56.6 0.0 3.8e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ORX72375.1 - 0.00098 19.5 0.0 0.0054 17.2 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 ORX72375.1 - 0.038 13.7 0.0 0.099 12.4 0.0 1.7 1 0 0 1 1 1 0 Cupin domain CoA_trans PF01144.23 ORX72376.1 - 3.8e-85 284.7 2.7 1.1e-52 178.6 0.2 3.1 2 1 0 2 2 2 2 Coenzyme A transferase CoA_trans PF01144.23 ORX72377.1 - 1.9e-56 190.9 0.1 6.8e-29 100.8 0.0 2.1 2 0 0 2 2 2 2 Coenzyme A transferase PWI PF01480.17 ORX72378.1 - 4e-28 97.5 0.2 1.2e-27 96.0 0.1 1.8 2 0 0 2 2 2 1 PWI domain Plectin PF00681.20 ORX72378.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Plectin repeat NOPS PF08075.11 ORX72378.1 - 0.041 14.1 0.0 0.081 13.1 0.0 1.4 1 0 0 1 1 1 0 NOPS (NUC059) domain Lipase_3 PF01764.25 ORX72380.1 - 2.5e-30 105.2 0.0 2.8e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.22 ORX72380.1 - 0.0067 16.4 0.0 0.0067 16.4 0.0 1.1 1 0 0 1 1 1 1 Cutinase Hydrolase_4 PF12146.8 ORX72380.1 - 0.0086 15.4 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 ORX72380.1 - 0.01 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX72380.1 - 0.01 16.4 0.0 0.011 16.4 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 ORX72380.1 - 0.092 12.2 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 ORX72380.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pirin_C PF05726.13 ORX72381.1 - 3.9e-23 81.8 0.0 7.1e-23 81.0 0.0 1.4 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX72381.1 - 5.6e-05 23.1 0.3 0.00012 22.0 0.3 1.6 1 0 0 1 1 1 1 Pirin DUF1254 PF06863.12 ORX72381.1 - 0.023 14.8 0.0 0.087 12.9 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1254) Chromo PF00385.24 ORX72382.1 - 2.1e-09 37.1 0.7 2.1e-09 37.1 0.7 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain adh_short_C2 PF13561.6 ORX72383.1 - 0.0024 17.4 0.2 0.0037 16.8 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CMD PF02627.20 ORX72383.1 - 0.049 13.7 0.2 0.12 12.5 0.2 1.7 1 1 0 1 1 1 0 Carboxymuconolactone decarboxylase family Chromo PF00385.24 ORX72384.1 - 1.1e-07 31.6 3.0 1.8e-07 30.9 3.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DHHC PF01529.20 ORX72385.1 - 3.2e-37 127.6 1.2 3.2e-37 127.6 1.2 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase YhhN PF07947.14 ORX72385.1 - 0.49 10.0 6.6 0.055 13.1 1.9 1.7 2 0 0 2 2 2 0 YhhN family Promethin PF16015.5 ORX72385.1 - 1.2 9.1 13.9 0.82 9.6 0.2 2.8 3 0 0 3 3 3 0 Promethin Peptidase_C50 PF03568.17 ORX72388.1 - 9.5e-101 337.8 0.0 1.2e-100 337.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 ORX72388.1 - 1.2e-06 28.2 5.7 0.00059 19.3 0.1 2.6 2 1 0 3 3 3 2 CHAT domain ADP_ribosyl_GH PF03747.14 ORX72388.1 - 0.0019 18.0 0.1 0.013 15.3 0.1 2.4 3 0 0 3 3 3 1 ADP-ribosylglycohydrolase XPG_N PF00752.17 ORX72389.1 - 2.7e-31 108.0 0.0 4.7e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ORX72389.1 - 7.6e-30 103.1 0.0 1.6e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 ORX72389.1 - 0.0065 17.0 0.1 0.035 14.7 0.0 2.1 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 ORX72389.1 - 0.034 14.1 0.0 0.089 12.7 0.0 1.7 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF1090 PF06476.12 ORX72389.1 - 0.24 11.5 4.3 0.47 10.6 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DAHP_synth_1 PF00793.20 ORX72390.1 - 4.3e-102 340.7 0.0 5.4e-102 340.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family DASH_Dam1 PF08653.10 ORX72390.1 - 0.14 12.0 0.0 0.35 10.7 0.0 1.7 1 1 0 1 1 1 0 DASH complex subunit Dam1 ECH_1 PF00378.20 ORX72391.1 - 1.5e-39 135.8 0.0 2e-39 135.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX72391.1 - 1.8e-16 60.6 0.2 1.6e-13 50.9 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Phage_TAC_3 PF06896.11 ORX72391.1 - 0.11 13.1 0.1 0.2 12.2 0.1 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC MFS_1 PF07690.16 ORX72393.1 - 2.1e-05 23.6 23.4 0.00044 19.3 3.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ArAE_1 PF06081.11 ORX72393.1 - 0.11 12.6 10.2 0.43 10.7 2.3 2.6 3 0 0 3 3 3 0 Aromatic acid exporter family member 1 Pga1 PF10333.9 ORX72394.1 - 0.00016 21.6 0.1 0.00028 20.8 0.1 1.4 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator MFS_1 PF07690.16 ORX72395.1 - 1.6e-36 125.9 26.3 4e-35 121.4 15.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 ORX72395.1 - 1.5e-05 23.6 2.2 1.5e-05 23.6 2.2 2.2 2 0 0 2 2 2 1 Transmembrane secretion effector PLDc_N PF13396.6 ORX72395.1 - 0.24 11.4 0.0 0.24 11.4 0.0 2.9 3 0 0 3 3 3 0 Phospholipase_D-nuclease N-terminal Tail_VII PF17091.5 ORX72395.1 - 0.32 10.9 0.1 0.32 10.9 0.1 3.6 4 0 0 4 4 4 0 Inovirus G7P protein MFS_1 PF07690.16 ORX72397.1 - 1.1e-37 129.8 33.4 6.4e-37 127.3 11.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2040 PF09745.9 ORX72398.1 - 1.7e-28 99.1 22.2 1.7e-28 99.1 22.2 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF2315 PF10231.9 ORX72398.1 - 2.4 8.3 10.6 0.078 13.1 3.8 2.1 2 1 0 2 2 2 0 Apoptogenic protein 1 Exo_endo_phos PF03372.23 ORX72399.1 - 6.5e-22 78.2 0.0 1.6e-21 76.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 ORX72399.1 - 1.6e-09 37.9 0.6 1.9e-05 24.9 0.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX72399.1 - 2e-05 24.2 2.1 0.0034 17.1 3.1 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 ORX72399.1 - 0.00018 21.6 0.8 0.67 10.7 0.0 4.0 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.6 ORX72399.1 - 0.96 9.7 3.1 31 5.0 0.8 3.2 3 0 0 3 3 3 0 Leucine Rich repeat Asn_synthase PF00733.21 ORX72400.1 - 3e-62 211.3 0.9 5.6e-35 121.6 0.0 3.0 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 ORX72400.1 - 3e-35 120.8 0.0 9.6e-35 119.2 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ORX72400.1 - 8.9e-29 100.4 0.0 1.7e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain MutS_V PF00488.21 ORX72401.1 - 2e-77 259.5 0.0 3e-77 258.9 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX72401.1 - 8e-06 26.2 0.2 1.6e-05 25.2 0.2 1.5 1 0 0 1 1 1 1 MutS domain III AAA_14 PF13173.6 ORX72401.1 - 0.008 16.2 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ORX72401.1 - 0.067 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 ORX72401.1 - 0.078 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ORX72401.1 - 0.17 11.8 0.0 0.4 10.6 0.0 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain G-alpha PF00503.20 ORX72401.1 - 0.19 10.8 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Exo_endo_phos PF03372.23 ORX72403.1 - 0.026 14.0 0.1 0.078 12.5 0.1 1.7 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family zf-RVT PF13966.6 ORX72404.1 - 0.004 17.8 0.0 0.012 16.3 0.0 1.9 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Sld5 PF05916.11 ORX72405.1 - 0.0031 18.0 0.1 0.0056 17.1 0.1 1.5 1 1 0 1 1 1 1 GINS complex protein Asp_protease_2 PF13650.6 ORX72407.1 - 0.0034 18.0 0.0 0.0089 16.7 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX72407.1 - 0.035 14.6 0.0 0.096 13.3 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease V_ATPase_I PF01496.19 ORX72407.1 - 0.35 8.7 1.8 0.65 7.8 1.3 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Rrp15p PF07890.12 ORX72407.1 - 0.47 10.8 7.6 0.15 12.4 3.2 2.1 2 0 0 2 2 2 0 Rrp15p zf-RVT PF13966.6 ORX72408.1 - 0.0045 17.7 0.1 0.018 15.7 0.1 2.1 1 1 0 1 1 1 1 zinc-binding in reverse transcriptase zf-C6H2 PF15801.5 ORX72409.1 - 0.13 12.6 3.4 0.22 11.8 3.4 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding MutS_V PF00488.21 ORX72411.1 - 1.6e-77 259.8 0.0 2.5e-77 259.2 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX72411.1 - 8.7e-06 26.1 0.2 1.6e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 MutS domain III AAA_14 PF13173.6 ORX72411.1 - 0.007 16.4 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 ORX72411.1 - 0.059 13.0 0.0 0.16 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ORX72411.1 - 0.063 13.0 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 ORX72411.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.8 1 1 0 1 1 1 0 Rad17 P-loop domain G-alpha PF00503.20 ORX72411.1 - 0.17 11.0 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Chitin_synth_2 PF03142.15 ORX72412.1 - 8e-209 694.6 1.3 3.9e-153 510.8 2.1 2.0 1 1 1 2 2 2 2 Chitin synthase DEK_C PF08766.11 ORX72412.1 - 3.3e-19 68.5 0.1 8e-19 67.3 0.1 1.7 1 0 0 1 1 1 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX72412.1 - 1.5e-11 44.6 0.0 7e-09 35.9 0.0 2.5 1 1 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX72412.1 - 5.6e-11 42.7 5.9 1.8e-10 41.1 5.9 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX72412.1 - 0.00019 21.3 0.0 0.97 9.2 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX72412.1 - 0.064 12.7 0.4 0.27 10.7 0.1 2.1 3 0 0 3 3 3 0 Glycosyl transferase family 21 FANCI_S4 PF14678.6 ORX72413.1 - 5.4e-26 91.2 0.0 1.5e-25 89.8 0.0 1.8 2 0 0 2 2 2 1 FANCI solenoid 4 FANCI_HD2 PF14680.6 ORX72413.1 - 8.8e-17 61.1 0.0 8.9e-11 41.5 0.0 2.5 2 0 0 2 2 2 2 FANCI helical domain 2 FANCI_HD1 PF14679.6 ORX72413.1 - 7.8e-16 57.8 0.0 2.1e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 FANCI helical domain 1 FANCI_S1 PF14675.6 ORX72413.1 - 1.4e-15 57.5 0.0 5.3e-14 52.3 0.0 2.5 1 1 0 1 1 1 1 FANCI solenoid 1 FANCI_S2 PF14676.6 ORX72413.1 - 4.4e-13 49.9 4.3 2.6e-12 47.4 0.9 3.3 3 1 0 3 3 3 1 FANCI solenoid 2 MFS_1 PF07690.16 ORX72415.1 - 1.2e-09 37.6 33.3 3.2e-07 29.6 18.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX72415.1 - 0.00018 20.5 6.4 0.00018 20.5 6.4 2.4 2 1 0 3 3 3 1 Sugar (and other) transporter PUCC PF03209.15 ORX72415.1 - 0.0049 15.9 11.8 0.0058 15.7 11.0 1.6 1 1 0 1 1 1 1 PUCC protein ADH_zinc_N PF00107.26 ORX72416.1 - 6.3e-27 94.1 0.2 9.7e-27 93.5 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX72416.1 - 3.2e-20 72.1 0.0 8e-20 70.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX72416.1 - 5.1e-10 40.5 0.0 1e-09 39.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 ORX72416.1 - 0.057 13.3 0.8 0.15 12.0 0.2 1.9 2 0 0 2 2 2 0 NAD(P)H-binding Kinesin PF00225.23 ORX72417.1 - 6.8e-69 232.3 0.0 1.5e-66 224.6 0.0 2.3 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ORX72417.1 - 3.3e-07 30.3 0.0 0.00022 21.2 0.0 2.7 1 1 1 2 2 2 2 Microtubule binding TPR_2 PF07719.17 ORX72417.1 - 0.00023 21.1 0.8 0.00068 19.6 0.8 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat HHH_3 PF12836.7 ORX72417.1 - 0.00072 19.8 0.1 0.0019 18.4 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif ATP-synt_D PF01813.17 ORX72417.1 - 0.0077 16.1 0.4 0.014 15.2 0.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit D TPR_1 PF00515.28 ORX72417.1 - 0.0084 15.9 0.2 0.022 14.5 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72417.1 - 0.013 16.2 0.3 0.037 14.9 0.3 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat HHH_5 PF14520.6 ORX72417.1 - 0.015 15.9 0.1 0.04 14.5 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain TPR_11 PF13414.6 ORX72417.1 - 0.059 13.1 0.0 0.18 11.5 0.0 1.8 1 0 0 1 1 1 0 TPR repeat Translin PF01997.16 ORX72418.1 - 6.9e-40 137.2 0.3 2.1e-39 135.7 0.3 1.7 1 1 0 1 1 1 1 Translin family V-SNARE PF05008.15 ORX72418.1 - 0.09 13.2 0.5 0.61 10.5 0.2 2.4 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PBECR3 PF18812.1 ORX72418.1 - 0.093 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 Choline_transpo PF04515.12 ORX72420.1 - 5.1e-80 269.1 23.5 5.1e-80 269.1 23.5 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter APP_Cu_bd PF12924.7 ORX72420.1 - 0.48 11.2 2.6 0.29 11.9 0.3 1.9 2 0 0 2 2 2 0 Copper-binding of amyloid precursor, CuBD LSM PF01423.22 ORX72421.1 - 4.1e-18 64.8 1.2 5.6e-18 64.4 1.2 1.2 1 0 0 1 1 1 1 LSM domain UDPG_MGDP_dh_N PF03721.14 ORX72422.1 - 5.8e-36 123.8 0.5 1.2e-34 119.5 0.5 2.6 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ORX72422.1 - 3.5e-33 114.1 0.0 3.3e-28 98.2 0.0 2.7 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ORX72422.1 - 5e-28 97.1 0.0 9.3e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_Gly3P_dh_N PF01210.23 ORX72422.1 - 0.018 15.0 0.0 0.052 13.5 0.0 1.8 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 ORX72422.1 - 0.029 14.9 0.0 2.5 8.7 0.0 2.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent RPAP1_C PF08620.10 ORX72422.1 - 0.2 11.8 0.6 0.48 10.6 0.2 1.9 2 0 0 2 2 2 0 RPAP1-like, C-terminal polyprenyl_synt PF00348.17 ORX72423.1 - 1.7e-81 273.1 0.0 2.3e-81 272.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase LCM PF04072.14 ORX72424.1 - 1.6e-26 93.4 0.0 2.4e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase RmlD_sub_bind PF04321.17 ORX72425.1 - 5.8e-56 189.7 0.2 7.3e-56 189.4 0.2 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ORX72425.1 - 5.9e-17 61.9 0.0 7.3e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX72425.1 - 1.6e-07 31.0 0.0 3.1e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ORX72425.1 - 1.7e-07 30.7 0.0 5.2e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ORX72425.1 - 3.6e-06 26.3 0.0 3.1e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF3421 PF11901.8 ORX72426.1 - 2.2e-23 82.5 0.0 5.1e-13 49.0 0.0 3.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) Dehydratase_MU PF02288.15 ORX72426.1 - 0.021 14.7 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 Dehydratase medium subunit MFS_1 PF07690.16 ORX72427.1 - 3.1e-16 59.3 19.4 9.3e-16 57.7 20.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily zf-RING_6 PF14835.6 ORX72427.1 - 0.0048 16.7 0.1 0.017 14.9 0.1 1.9 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF4620 PF15399.6 ORX72427.1 - 0.0057 17.0 0.2 0.013 15.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4620) CE2_N PF17996.1 ORX72428.1 - 0.18 11.8 0.0 1.3 9.0 0.0 2.3 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal CwfJ_C_1 PF04677.15 ORX72430.1 - 1e-27 96.4 0.1 2e-27 95.5 0.1 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 ORX72430.1 - 6.4e-26 91.1 0.5 2e-24 86.3 0.5 2.6 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Ion_trans PF00520.31 ORX72431.1 - 4.5e-27 94.9 20.0 5.6e-27 94.5 20.0 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ORX72431.1 - 4.3e-11 42.6 7.4 4.3e-11 42.6 7.4 2.7 2 2 0 2 2 2 1 Ion channel Macoilin PF09726.9 ORX72431.1 - 3.6 6.0 4.0 4.9 5.6 4.0 1.1 1 0 0 1 1 1 0 Macoilin family NAM-associated PF14303.6 ORX72432.1 - 7.2e-05 23.6 0.0 0.00023 21.9 0.0 1.9 1 1 0 1 1 1 1 No apical meristem-associated C-terminal domain Flu_M1_C PF08289.11 ORX72432.1 - 0.02 15.1 0.0 0.11 12.8 0.0 2.2 1 1 1 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain IMD PF08397.11 ORX72432.1 - 0.066 12.6 2.5 0.13 11.6 2.3 1.5 1 1 0 1 1 1 0 IRSp53/MIM homology domain PDE6_gamma PF04868.12 ORX72432.1 - 0.13 12.5 0.1 0.13 12.5 0.1 1.8 2 0 0 2 2 2 0 Retinal cGMP phosphodiesterase, gamma subunit Ndc1_Nup PF09531.10 ORX72432.1 - 0.7 8.5 3.7 0.81 8.3 3.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Phage_Mu_Gam PF07352.12 ORX72432.1 - 2.6 8.0 7.5 35 4.3 6.8 2.7 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein RNA_pol_Rbc25 PF08292.12 ORX72433.1 - 3e-32 111.6 0.4 6.6e-30 104.0 0.4 2.4 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 ORX72433.1 - 1.2e-14 54.4 0.0 2.7e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 polyprenyl_synt PF00348.17 ORX72434.1 - 5.4e-69 232.1 0.0 1e-68 231.2 0.0 1.4 1 1 0 1 1 1 1 Polyprenyl synthetase AAA PF00004.29 ORX72435.1 - 1.2e-45 155.1 0.0 1.8e-28 99.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX72435.1 - 4e-22 77.7 0.1 1.1e-10 41.1 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX72435.1 - 3.1e-06 27.7 0.8 0.0023 18.3 0.0 4.0 2 2 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ORX72435.1 - 6.5e-05 23.1 0.0 0.018 15.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX72435.1 - 0.0041 16.9 0.0 0.017 14.9 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 ORX72435.1 - 0.0059 16.6 0.2 0.059 13.4 0.0 2.7 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 ORX72435.1 - 0.0064 16.4 0.6 1.4 8.8 0.1 2.6 3 0 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 ORX72435.1 - 0.0095 15.9 0.0 0.037 14.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX72435.1 - 0.014 15.6 0.4 0.33 11.2 0.1 3.2 2 1 2 4 4 3 0 AAA domain AAA_14 PF13173.6 ORX72435.1 - 0.022 14.8 0.0 0.082 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ORX72435.1 - 0.029 13.9 0.0 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ORX72435.1 - 0.047 13.1 0.1 0.097 12.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ORX72435.1 - 0.13 12.6 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 ORX72435.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX72435.1 - 0.21 11.3 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ParA PF10609.9 ORX72436.1 - 2.5e-93 312.1 0.0 2.8e-93 311.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ORX72436.1 - 1.8e-09 37.8 0.0 3.8e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 ORX72436.1 - 2.9e-09 36.6 0.0 4e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 ORX72436.1 - 3.8e-09 36.7 0.1 2.1e-06 27.8 0.1 2.2 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 ORX72436.1 - 7.9e-06 25.3 0.9 1.6e-05 24.3 0.2 1.8 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 ORX72436.1 - 0.00047 19.8 0.1 0.00083 19.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 ORX72436.1 - 0.00052 19.1 0.2 0.00076 18.5 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 ORX72436.1 - 0.00053 19.5 0.2 0.0067 15.9 0.1 2.0 1 1 1 2 2 2 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 ORX72436.1 - 0.0079 15.7 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family APS_kinase PF01583.20 ORX72436.1 - 0.0095 15.8 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase CLP1_P PF16575.5 ORX72436.1 - 0.035 13.9 0.1 0.077 12.8 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 ORX72436.1 - 0.068 12.5 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 VirC1 protein RsgA_GTPase PF03193.16 ORX72436.1 - 0.25 11.2 0.3 0.47 10.3 0.3 1.4 1 0 0 1 1 1 0 RsgA GTPase Glyco_transf_24 PF18404.1 ORX72438.1 - 5.9e-147 488.2 3.3 9.7e-147 487.5 3.3 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 ORX72438.1 - 1.1e-51 176.2 0.1 2.6e-49 168.5 0.1 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ORX72438.1 - 2.7e-33 115.4 0.7 6.5e-33 114.2 0.7 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 ORX72438.1 - 2e-28 98.7 0.0 4.6e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 ORX72438.1 - 6.4e-25 87.7 0.7 3.2e-24 85.4 0.5 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ORX72438.1 - 1.1e-15 58.2 0.0 5.4e-15 55.9 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 ORX72438.1 - 3.3e-06 26.9 0.2 6.3e-06 25.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 FAD_binding_1 PF00667.20 ORX72439.1 - 8.4e-28 97.4 0.0 1.3e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX72439.1 - 6e-23 81.6 0.0 1.2e-21 77.4 0.0 2.4 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX72439.1 - 2.8e-13 50.5 0.0 5.5e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX72439.1 - 0.011 16.1 0.0 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Flavodoxin_5 PF12724.7 ORX72439.1 - 0.015 15.5 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain PrmA PF06325.13 ORX72440.1 - 1.2e-06 28.2 0.0 3e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ORX72440.1 - 4.7e-05 24.0 0.0 0.00029 21.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ORX72440.1 - 0.002 17.7 0.0 0.0044 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX72440.1 - 0.0042 17.0 0.0 0.0079 16.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX72440.1 - 0.02 15.6 0.0 0.27 12.0 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.12 ORX72440.1 - 0.028 15.1 0.0 0.12 13.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX72440.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Pro_isomerase PF00160.21 ORX72441.1 - 1.2e-46 158.9 0.0 1.4e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SHMT PF00464.19 ORX72442.1 - 3.7e-169 562.6 0.0 4.5e-169 562.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 ORX72442.1 - 0.051 12.9 0.0 0.083 12.2 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ORX72442.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX72442.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase zf-LITAF-like PF10601.9 ORX72443.1 - 7.1e-14 51.8 9.0 9.7e-14 51.4 9.0 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Zn-ribbon_8 PF09723.10 ORX72443.1 - 0.0036 17.4 0.8 1.7 8.8 0.1 2.6 2 0 0 2 2 2 2 Zinc ribbon domain NOB1_Zn_bind PF08772.11 ORX72443.1 - 0.031 14.4 8.2 0.9 9.7 0.1 2.2 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like HypA PF01155.19 ORX72443.1 - 0.049 13.6 7.6 0.37 10.8 7.6 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Elf1 PF05129.13 ORX72443.1 - 2.9 8.0 9.1 1.2 9.2 3.9 2.2 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like LRR_4 PF12799.7 ORX72444.1 - 1.2 9.7 5.7 7.8 7.1 0.2 4.1 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) ATG16 PF08614.11 ORX72445.1 - 2.4e-05 24.6 12.6 3.3e-05 24.2 12.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 ORX72445.1 - 0.0035 17.5 8.0 0.0035 17.5 8.0 1.7 2 0 0 2 2 1 1 Tropomyosin like FPP PF05911.11 ORX72445.1 - 0.0048 15.2 7.8 0.006 14.8 7.8 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil FAM76 PF16046.5 ORX72445.1 - 0.0078 15.6 8.0 0.0094 15.3 8.0 1.1 1 0 0 1 1 1 1 FAM76 protein DUF722 PF05263.11 ORX72445.1 - 0.013 15.7 2.8 2.8 8.2 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF722) Sec8_exocyst PF04048.14 ORX72445.1 - 0.017 15.0 0.8 0.032 14.1 0.8 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Fez1 PF06818.15 ORX72445.1 - 0.017 15.6 6.7 0.017 15.6 6.7 1.7 1 1 1 2 2 2 0 Fez1 DUF724 PF05266.14 ORX72445.1 - 0.02 14.7 3.9 0.04 13.7 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 ORX72445.1 - 0.027 14.5 6.0 0.027 14.5 6.0 1.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein GrpE PF01025.19 ORX72445.1 - 0.047 13.4 5.8 0.094 12.4 5.8 1.5 1 0 0 1 1 1 0 GrpE DUF4763 PF15960.5 ORX72445.1 - 0.094 12.0 7.4 0.2 10.9 7.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) Med9 PF07544.13 ORX72445.1 - 0.096 12.8 3.7 0.23 11.6 3.7 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 MPS2 PF17060.5 ORX72445.1 - 0.12 11.6 2.3 0.18 11.0 2.3 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 AAA_13 PF13166.6 ORX72445.1 - 0.13 10.8 3.1 0.18 10.4 3.1 1.2 1 0 0 1 1 1 0 AAA domain OEP PF02321.18 ORX72445.1 - 0.58 9.9 6.7 0.84 9.4 6.7 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein FemAB PF02388.16 ORX72445.1 - 0.59 8.9 3.6 0.98 8.2 3.6 1.3 1 0 0 1 1 1 0 FemAB family XhlA PF10779.9 ORX72445.1 - 0.63 10.3 3.6 1.2 9.4 3.6 1.5 1 0 0 1 1 1 0 Haemolysin XhlA Spc7 PF08317.11 ORX72445.1 - 0.71 8.7 10.2 1.9 7.3 10.2 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 ORX72445.1 - 0.72 9.1 7.2 0.93 8.8 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 ORX72445.1 - 0.91 8.8 14.1 0.41 9.9 8.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) STAT_int PF02865.17 ORX72445.1 - 0.97 9.9 5.1 7.7 7.0 0.2 2.5 2 1 0 2 2 2 0 STAT protein, protein interaction domain TMF_DNA_bd PF12329.8 ORX72445.1 - 2.3 8.3 14.2 0.21 11.6 5.9 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding COG2 PF06148.11 ORX72445.1 - 2.3 8.3 7.5 1.4 9.0 3.3 2.2 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YlqD PF11068.8 ORX72445.1 - 2.9 8.3 12.9 0.11 12.9 5.8 2.0 2 0 0 2 2 2 0 YlqD protein LMBR1 PF04791.16 ORX72445.1 - 3.1 6.6 3.3 2.1 7.1 2.3 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein HSCB_C PF07743.13 ORX72445.1 - 4 8.0 10.6 1.1 9.9 6.9 2.0 2 0 0 2 2 1 0 HSCB C-terminal oligomerisation domain Tau95 PF09734.9 ORX72445.1 - 4 8.2 6.4 1.8 9.3 0.3 2.3 1 1 1 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain FUSC PF04632.12 ORX72445.1 - 7.4 5.0 6.4 10 4.5 6.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family G-patch PF01585.23 ORX72447.1 - 1.2e-11 44.3 0.3 3.3e-11 42.9 0.3 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX72447.1 - 1.6e-05 24.9 0.1 1.6e-05 24.9 0.1 3.3 2 1 0 2 2 2 1 G-patch domain Coilin_N PF15862.5 ORX72447.1 - 0.0054 16.5 14.9 0.0085 15.9 14.9 1.5 1 0 0 1 1 1 1 Coilin N-terminus EOS1 PF12326.8 ORX72447.1 - 0.51 10.2 1.6 0.55 10.1 1.6 1.4 1 0 0 1 1 1 0 N-glycosylation protein DUF2052 PF09747.9 ORX72447.1 - 0.81 9.8 14.6 1.4 9.1 14.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RNA_polI_A34 PF08208.11 ORX72447.1 - 3.2 7.8 37.7 3.2 7.8 36.3 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 ORX72447.1 - 3.4 7.4 21.0 5.5 6.7 21.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paramyxo_ncap PF00973.19 ORX72447.1 - 4.1 6.2 7.5 4.9 5.9 7.5 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AAA_11 PF13086.6 ORX72447.1 - 7.8 6.2 14.8 10 5.8 14.8 1.2 1 0 0 1 1 1 0 AAA domain COX7a PF02238.15 ORX72448.1 - 5.9e-09 36.2 0.1 6.9e-09 36.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII SAD_SRA PF02182.17 ORX72449.1 - 1.1e-46 158.3 0.0 1.8e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 SAD/SRA domain zf-C3HC4_2 PF13923.6 ORX72449.1 - 7.5e-09 35.3 14.3 7.5e-09 35.3 14.3 3.6 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX72449.1 - 1.6e-07 31.0 12.3 1.6e-07 31.0 12.3 2.8 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 ORX72449.1 - 8.8e-07 28.7 17.0 8.8e-07 28.7 17.0 3.7 2 2 0 2 2 1 1 PHD-finger zf-RING_UBOX PF13445.6 ORX72449.1 - 2.5e-06 27.4 6.7 2.5e-06 27.4 6.7 3.2 2 2 0 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX72449.1 - 2.3e-05 24.2 12.6 2.3e-05 24.2 12.6 3.2 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX72449.1 - 7.1e-05 22.6 14.3 7.1e-05 22.6 14.3 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX72449.1 - 0.00011 22.5 13.3 0.00011 22.5 13.3 3.3 2 1 0 2 2 2 1 Ring finger domain ubiquitin PF00240.23 ORX72449.1 - 0.00026 20.7 0.0 0.0005 19.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family zf-C3HC4_4 PF15227.6 ORX72449.1 - 0.00027 21.0 12.1 0.00027 21.0 12.1 3.4 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ORX72449.1 - 0.00081 19.2 11.4 0.00081 19.2 11.4 3.2 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 ORX72449.1 - 0.0089 16.1 7.3 0.0089 16.1 7.3 2.8 2 1 0 2 2 1 1 zinc RING finger of MSL2 DUF2407 PF10302.9 ORX72449.1 - 0.011 16.3 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain zf-rbx1 PF12678.7 ORX72449.1 - 7.5 6.9 29.6 2 8.7 8.1 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain Myb_DNA-bind_6 PF13921.6 ORX72451.1 - 0.0044 17.3 0.1 0.0058 16.9 0.1 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX72451.1 - 0.11 12.8 0.4 0.15 12.2 0.4 1.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain E2F_TDP PF02319.20 ORX72451.1 - 0.11 12.6 0.2 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain NmrA PF05368.13 ORX72452.1 - 6.8e-45 153.4 0.1 8.5e-45 153.1 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX72452.1 - 1.7e-15 57.4 0.0 2.2e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX72452.1 - 7.6e-06 25.6 0.1 1e-05 25.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX72452.1 - 9.9e-06 24.7 0.0 1.3e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 ORX72452.1 - 0.002 18.5 0.0 0.0037 17.7 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 ORX72452.1 - 0.0035 17.3 0.0 0.026 14.4 0.0 2.0 2 0 0 2 2 2 1 KR domain DXP_reductoisom PF02670.16 ORX72452.1 - 0.0061 17.3 0.0 0.011 16.5 0.0 1.5 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Nup35_RRM_2 PF14605.6 ORX72452.1 - 0.0067 16.4 0.1 0.022 14.7 0.1 1.9 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Polysacc_synt_2 PF02719.15 ORX72452.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein zf-RING_2 PF13639.6 ORX72454.1 - 6.3e-10 39.2 8.2 1.1e-09 38.5 8.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ORX72454.1 - 6.7e-08 32.3 7.5 1.3e-07 31.3 7.5 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX72454.1 - 2.5e-06 27.7 12.5 7e-06 26.2 11.9 2.0 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX72454.1 - 1.9e-05 24.6 6.8 2.8e-05 24.1 6.8 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ORX72454.1 - 2.1e-05 24.2 11.5 7.9e-05 22.4 11.5 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ORX72454.1 - 2.5e-05 24.4 7.6 6.4e-05 23.0 7.6 1.7 1 1 0 1 1 1 1 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ORX72454.1 - 0.0005 19.6 7.2 0.0011 18.6 7.2 1.6 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX72454.1 - 0.00077 19.5 7.4 0.0016 18.5 7.4 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_11 PF17123.5 ORX72454.1 - 0.0057 16.4 5.2 0.015 15.0 5.2 1.8 1 1 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX72454.1 - 0.0069 16.4 2.1 0.0069 16.4 2.1 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING-like PF08746.11 ORX72454.1 - 0.0082 16.4 5.9 0.0082 16.4 5.9 1.8 2 0 0 2 2 2 1 RING-like domain PHD PF00628.29 ORX72454.1 - 0.015 15.2 6.7 0.025 14.4 6.7 1.4 1 0 0 1 1 1 0 PHD-finger zf-Nse PF11789.8 ORX72454.1 - 0.017 15.0 3.6 0.031 14.1 3.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 ORX72454.1 - 0.017 14.9 6.0 0.076 12.8 6.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RWD PF05773.22 ORX72454.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 RWD domain zf-UDP PF14569.6 ORX72454.1 - 0.13 12.4 1.9 0.2 11.8 1.9 1.3 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 ORX72454.1 - 0.5 10.3 9.3 1.6 8.7 9.4 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Zf_RING PF16744.5 ORX72454.1 - 0.97 9.6 6.1 3.1 8.0 6.1 1.9 1 1 0 1 1 1 0 KIAA1045 RING finger C1_1 PF00130.22 ORX72454.1 - 1 9.3 9.8 0.42 10.5 5.2 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_3 PF13920.6 ORX72454.1 - 2.6 8.0 9.6 13 5.8 9.6 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.10 ORX72454.1 - 3.8 7.7 6.9 0.93 9.7 3.4 1.8 2 0 0 2 2 1 0 Zinc ribbon domain TPT PF03151.16 ORX72455.1 - 1.8e-19 70.2 14.0 2.9e-19 69.5 14.0 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ORX72455.1 - 2.1e-06 27.2 17.7 3.2e-05 23.3 17.7 2.0 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX72455.1 - 3.9 7.7 28.9 4.8 7.4 18.6 3.0 1 1 0 2 2 2 0 EamA-like transporter family Tctex-1 PF03645.13 ORX72456.1 - 6.9e-18 64.8 0.1 7.9e-18 64.6 0.1 1.1 1 0 0 1 1 1 1 Tctex-1 family VPS9 PF02204.18 ORX72457.1 - 1.6e-21 76.5 0.0 3.3e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain HbrB PF08539.11 ORX72458.1 - 4.3e-19 69.1 0.6 1.7e-16 60.7 0.6 2.5 1 1 0 1 1 1 1 HbrB-like Glyco_hydro_46 PF01374.18 ORX72459.1 - 3.2e-44 151.1 3.8 1.2e-43 149.2 3.8 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 Pirin_C PF05726.13 ORX72460.1 - 2.1e-23 82.6 0.0 3.9e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX72460.1 - 5.6e-05 23.1 0.3 0.00012 22.0 0.3 1.6 1 0 0 1 1 1 1 Pirin DUF1254 PF06863.12 ORX72460.1 - 0.0054 16.8 0.0 0.016 15.2 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1254) 7tm_3 PF00003.22 ORX72463.1 - 1.3e-05 25.0 19.5 2e-05 24.4 19.5 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR MFS_1 PF07690.16 ORX72464.1 - 3.4e-22 78.9 33.8 3.4e-22 78.9 33.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF5392 PF17370.2 ORX72464.1 - 0.12 12.5 0.3 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5392) Transketolase_N PF00456.21 ORX72465.1 - 3.1e-151 503.1 0.0 3.9e-151 502.7 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ORX72465.1 - 3.7e-43 147.3 0.0 1.7e-42 145.1 0.0 2.1 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX72465.1 - 6.3e-10 39.0 0.0 2.2e-09 37.2 0.0 1.9 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ORX72465.1 - 2.5e-06 26.9 0.0 4.7e-05 22.7 0.0 2.0 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ORX72465.1 - 0.0065 16.3 1.7 0.028 14.2 0.1 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Terpene_synth PF01397.21 ORX72465.1 - 0.02 14.6 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain Phage-tail_1 PF09097.10 ORX72465.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Beta-Casp PF10996.8 ORX72466.1 - 5.7e-23 81.3 0.0 1.6e-22 79.9 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ORX72466.1 - 1.1e-17 64.1 0.0 2e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX72466.1 - 6.8e-16 58.9 0.5 4.3e-13 49.7 0.1 2.5 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ORX72466.1 - 2.1e-15 56.4 0.0 4.5e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ORX72466.1 - 6.4e-10 38.9 2.0 4e-09 36.3 0.5 2.3 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX72466.1 - 0.00085 19.2 0.0 0.0029 17.5 0.0 2.0 2 1 0 2 2 2 1 Beta-lactamase superfamily domain YhzD PF14120.6 ORX72466.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 YhzD-like protein OCD_Mu_crystall PF02423.15 ORX72468.1 - 0.029 13.3 0.1 0.033 13.1 0.1 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family CBM_14 PF01607.24 ORX72468.1 - 0.046 13.9 1.5 0.046 13.9 1.5 2.1 2 1 0 2 2 2 0 Chitin binding Peritrophin-A domain CBM_1 PF00734.18 ORX72468.1 - 0.053 13.5 8.9 0.86 9.6 0.9 3.8 4 0 0 4 4 4 0 Fungal cellulose binding domain Mito_carr PF00153.27 ORX72469.1 - 3.1e-51 171.3 7.5 8.3e-22 76.9 0.1 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein HMD PF03201.16 ORX72469.1 - 0.0093 16.2 1.4 1.7 8.9 0.0 3.1 3 1 0 3 3 3 2 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Arf PF00025.21 ORX72471.1 - 1.5e-69 232.9 0.3 1.7e-69 232.7 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ORX72471.1 - 3.5e-12 46.2 0.4 1e-06 28.2 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ORX72471.1 - 7.6e-12 45.5 0.0 1.1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX72471.1 - 2.5e-09 37.0 0.0 2.9e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ORX72471.1 - 7.1e-09 35.3 0.0 9.4e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX72471.1 - 2.2e-07 30.9 0.0 3.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX72471.1 - 2.7e-07 30.2 0.0 3.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX72471.1 - 0.00039 20.0 0.0 0.0093 15.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ORX72471.1 - 0.0024 16.9 0.1 0.056 12.4 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 ORX72471.1 - 0.055 12.9 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 ORX72471.1 - 0.072 12.8 0.0 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AMP-binding PF00501.28 ORX72472.1 - 7.4e-68 229.1 0.0 6.9e-65 219.3 0.0 3.0 1 1 0 1 1 1 1 AMP-binding enzyme DUF3913 PF13052.6 ORX72472.1 - 0.069 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3913) OCIA PF07051.11 ORX72472.1 - 0.17 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Ovarian carcinoma immunoreactive antigen (OCIA) AF-4 PF05110.13 ORX72473.1 - 0.0001 20.6 11.0 0.0001 20.6 11.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Cwf_Cwc_15 PF04889.12 ORX72473.1 - 0.016 14.9 6.8 0.017 14.9 6.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ORX72473.1 - 0.052 12.9 6.2 0.06 12.7 6.2 1.1 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ORX72473.1 - 0.71 9.5 2.5 1.1 8.9 2.5 1.3 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ORX72473.1 - 0.75 7.8 9.6 0.93 7.5 9.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 ORX72473.1 - 1.3 9.1 7.6 1.5 8.9 7.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Tom22 PF04281.13 ORX72473.1 - 1.5 8.6 5.2 2.2 8.1 5.2 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 AMP-binding PF00501.28 ORX72477.1 - 7e-90 301.6 0.0 8.9e-90 301.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX72477.1 - 0.00041 21.3 0.0 0.0017 19.3 0.0 2.0 1 1 1 2 2 2 1 AMP-binding enzyme C-terminal domain ADK PF00406.22 ORX72478.1 - 1.6e-44 151.7 0.0 2.1e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX72478.1 - 3.6e-32 111.6 0.1 1.6e-31 109.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX72478.1 - 2.3e-09 37.9 0.2 5.3e-09 36.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX72478.1 - 3.9e-06 27.1 0.1 4.1e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX72478.1 - 0.01 15.1 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AMP-binding PF00501.28 ORX72479.1 - 1.2e-90 304.1 0.0 1.6e-90 303.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX72479.1 - 0.22 12.5 0.0 0.46 11.5 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain AKAP7_NLS PF10469.9 ORX72480.1 - 4.2e-36 124.8 0.0 6.3e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 ORX72480.1 - 1.6e-13 50.3 0.2 2.9e-13 49.4 0.2 1.4 1 0 0 1 1 1 1 KH domain 2_5_RNA_ligase2 PF13563.6 ORX72480.1 - 0.0028 17.6 0.0 0.0072 16.2 0.0 1.7 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily KH_4 PF13083.6 ORX72480.1 - 0.029 14.2 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 KH domain MutS_V PF00488.21 ORX72481.1 - 8.8e-70 234.6 0.0 1e-69 234.3 0.0 1.0 1 0 0 1 1 1 1 MutS domain V GDI PF00996.18 ORX72484.1 - 7.9e-46 156.5 0.0 1.5e-30 106.2 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor PAP2_C PF14360.6 ORX72485.1 - 1.1e-14 54.7 13.6 1.1e-14 54.7 13.6 2.0 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ORX72485.1 - 1.1e-06 28.5 11.0 1.1e-06 28.5 11.0 1.5 1 1 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 ORX72485.1 - 1 9.0 15.4 2 8.1 15.4 1.5 1 1 0 1 1 1 0 PAP2 superfamily PAP2_C PF14360.6 ORX72486.1 - 1.1e-14 54.7 12.4 1.1e-14 54.7 12.4 2.6 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ORX72486.1 - 0.0012 18.7 10.6 0.0012 18.7 10.6 2.2 2 1 0 2 2 2 1 PAP2 superfamily zinc_ribbon_10 PF10058.9 ORX72487.1 - 2.7e-16 59.0 0.2 4.7e-16 58.2 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein NMD3 PF04981.13 ORX72487.1 - 0.027 13.9 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 NMD3 family TFIIF_alpha PF05793.12 ORX72487.1 - 0.045 12.4 11.7 0.087 11.4 11.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mu-like_Com PF10122.9 ORX72487.1 - 0.072 12.6 0.2 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com TB2_DP1_HVA22 PF03134.19 ORX72487.1 - 0.078 12.9 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 TB2/DP1, HVA22 family SLATT_5 PF18160.1 ORX72487.1 - 0.2 11.0 0.1 0.39 10.0 0.1 1.4 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 zf-ribbon_3 PF13248.6 ORX72487.1 - 0.43 10.1 2.5 0.43 10.0 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Tyr-DNA_phospho PF06087.12 ORX72489.1 - 9e-52 176.4 0.1 1.4e-51 175.7 0.1 1.2 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase DEAD_2 PF06733.15 ORX72489.1 - 2.5e-49 167.3 0.0 4.1e-49 166.6 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 ORX72489.1 - 2.5e-37 128.7 0.0 2.2e-36 125.6 0.0 2.4 1 1 0 1 1 1 1 Helicase C-terminal domain PLDc_2 PF13091.6 ORX72489.1 - 6.5e-05 22.8 0.0 0.054 13.4 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain ResIII PF04851.15 ORX72489.1 - 0.0057 16.7 0.0 5.6 6.9 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX72489.1 - 0.06 12.8 0.0 16 4.9 0.0 2.7 3 0 0 3 3 3 0 PhoH-like protein EF-hand_4 PF12763.7 ORX72490.1 - 1.6e-10 40.9 0.0 2.8e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 ORX72490.1 - 4e-09 36.2 0.0 6.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX72490.1 - 1.3e-06 27.9 0.0 6.5e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ORX72490.1 - 6.6e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Sigma70_r1_1 PF03979.14 ORX72490.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 SUIM_assoc PF16619.5 ORX72490.1 - 0.55 10.3 5.3 0.53 10.4 2.9 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF1712 PF08217.11 ORX72491.1 - 1.3e-15 57.0 0.0 1.8e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 Fungal domain of unknown function (DUF1712) AAA_PrkA PF08298.11 ORX72491.1 - 0.18 10.6 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain Spt20 PF12090.8 ORX72491.1 - 0.26 10.9 7.2 0.46 10.0 7.2 1.3 1 0 0 1 1 1 0 Spt20 family CBM_6 PF03422.15 ORX72492.1 - 0.049 13.9 0.2 0.22 11.8 0.1 1.9 1 1 1 2 2 2 0 Carbohydrate binding module (family 6) Sugar_tr PF00083.24 ORX72493.1 - 3.4e-76 256.9 14.1 2.1e-72 244.4 14.1 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX72493.1 - 5.4e-16 58.5 10.9 6.5e-16 58.2 10.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2530 PF10745.9 ORX72493.1 - 0.54 10.5 5.0 0.21 11.9 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Sugar_tr PF00083.24 ORX72494.1 - 2.4e-84 283.8 6.7 2.2e-65 221.3 0.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX72494.1 - 3e-15 56.0 10.4 3e-15 56.0 10.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 ORX72494.1 - 0.0013 17.3 1.8 0.0028 16.3 1.8 1.5 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_3 PF05977.13 ORX72494.1 - 0.023 13.1 0.7 0.037 12.4 0.7 1.3 1 0 0 1 1 1 0 Transmembrane secretion effector DUF4110 PF13422.6 ORX72494.1 - 0.22 11.6 0.1 0.36 10.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) PAP2_C PF14360.6 ORX72495.1 - 1.8e-15 57.3 12.5 1.8e-15 57.3 12.5 1.8 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ORX72495.1 - 1.2e-07 31.6 8.4 2.7e-07 30.4 8.4 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 ORX72495.1 - 0.025 14.3 14.0 0.055 13.2 14.0 1.6 1 1 0 1 1 1 0 PAP2 superfamily Peptidase_M16 PF00675.20 ORX72496.1 - 4.6e-22 78.6 0.2 9.3e-22 77.6 0.2 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX72496.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_S9 PF00326.21 ORX72497.1 - 1.5e-36 125.9 0.1 5.1e-35 120.9 0.1 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ORX72497.1 - 3.9e-05 23.3 0.0 8.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 ORX72497.1 - 0.0001 21.1 0.1 0.0029 16.3 0.1 2.5 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 ORX72497.1 - 0.00052 19.9 0.5 0.22 11.4 0.1 2.4 1 1 0 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.20 ORX72497.1 - 0.04 13.6 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Abhydrolase_1 PF00561.20 ORX72497.1 - 0.067 12.8 0.1 1.6 8.3 0.1 2.7 2 1 0 3 3 3 0 alpha/beta hydrolase fold GCD14 PF08704.10 ORX72498.1 - 1.6e-12 47.6 0.1 1.2e-10 41.4 0.0 2.6 2 1 1 3 3 3 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 ORX72498.1 - 0.00069 19.4 0.0 0.00097 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14_N PF14801.6 ORX72498.1 - 0.011 15.5 0.1 0.027 14.3 0.1 1.6 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term RrnaAD PF00398.20 ORX72498.1 - 0.054 12.5 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 ORX72498.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HLH PF00010.26 ORX72499.1 - 8.8e-08 32.0 1.1 8.8e-08 32.0 1.1 1.6 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain E1-E2_ATPase PF00122.20 ORX72501.1 - 4.6e-22 78.4 0.6 1.3e-20 73.7 0.6 2.6 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX72501.1 - 6.9e-08 33.0 1.4 0.00096 19.5 0.4 2.6 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Intein_splicing PF14890.6 ORX72501.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 1 0 1 1 1 0 Intein splicing domain Cation_ATPase_N PF00690.26 ORX72501.1 - 0.067 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Phage_holin_3_6 PF07332.11 ORX72501.1 - 0.18 11.9 12.2 2 8.5 1.0 3.9 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III F-box-like PF12937.7 ORX72502.1 - 0.0038 17.1 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 F-box-like V-ATPase_H_C PF11698.8 ORX72504.1 - 1.6e-39 134.7 0.1 4.4e-39 133.2 0.0 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 ORX72504.1 - 1.2e-32 113.4 0.0 2.2e-18 66.6 0.0 2.4 1 1 1 2 2 2 2 V-ATPase subunit H Aminotran_1_2 PF00155.21 ORX72505.1 - 6.5e-60 203.2 0.0 7.7e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX72505.1 - 6.5e-06 25.6 0.0 9.2e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX72505.1 - 5.8e-05 22.2 0.0 8.4e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 ORX72505.1 - 0.0058 15.4 0.0 0.015 14.1 0.0 1.5 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 ORX72505.1 - 0.006 15.9 0.0 0.021 14.1 0.0 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ORX72505.1 - 0.12 10.8 0.0 0.2 10.1 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CCSAP PF15748.5 ORX72506.1 - 0.2 11.8 17.4 0.32 11.1 17.4 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Mucin15 PF15672.5 ORX72507.1 - 0.0019 17.8 0.1 0.0021 17.6 0.1 1.0 1 0 0 1 1 1 1 Cell-membrane associated Mucin15 Herpes_US12 PF05363.12 ORX72507.1 - 0.094 13.4 2.2 0.18 12.6 2.2 1.4 1 0 0 1 1 1 0 Herpesvirus US12 family Spt20 PF12090.8 ORX72507.1 - 2.7 7.5 6.6 3.9 7.0 6.6 1.3 1 0 0 1 1 1 0 Spt20 family SNF5 PF04855.12 ORX72508.1 - 5.6e-48 163.8 0.0 4.6e-25 88.8 0.0 2.0 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 CybS PF05328.12 ORX72509.1 - 2.9e-26 91.7 0.2 3.3e-26 91.6 0.2 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Mito_carr PF00153.27 ORX72510.1 - 3.5e-48 161.5 12.2 2.2e-17 62.7 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4244 PF14029.6 ORX72510.1 - 0.18 11.3 0.2 0.18 11.3 0.2 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF4244) adh_short_C2 PF13561.6 ORX72512.1 - 2.5e-43 148.3 0.0 3.1e-43 148.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX72512.1 - 7.5e-41 139.7 0.1 9.1e-41 139.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX72512.1 - 0.022 14.7 0.1 0.039 13.9 0.1 1.4 1 0 0 1 1 1 0 KR domain HECT PF00632.25 ORX72513.1 - 2.6e-20 73.1 0.0 3.8e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) 60KD_IMP PF02096.20 ORX72601.1 - 2.1e-16 60.3 0.1 2.9e-16 59.8 0.1 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein zf-C3HC4_3 PF13920.6 ORX72602.1 - 0.0017 18.2 4.9 0.0017 18.2 4.9 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX72602.1 - 0.022 14.6 5.5 0.022 14.6 5.5 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Clathrin_lg_ch PF01086.17 ORX72604.1 - 3.1e-34 119.0 8.2 4.1e-34 118.6 8.2 1.2 1 0 0 1 1 1 1 Clathrin light chain OMS28_porin PF03532.13 ORX72604.1 - 0.0059 15.9 0.1 0.011 15.0 0.1 1.4 1 1 0 1 1 1 1 OMS28 porin DUF234 PF03008.14 ORX72604.1 - 0.031 14.7 1.2 0.049 14.1 1.2 1.2 1 0 0 1 1 1 0 Archaea bacterial proteins of unknown function DUF4521 PF15021.6 ORX72604.1 - 0.049 13.6 4.6 0.08 12.9 3.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4521) DUF768 PF05589.11 ORX72604.1 - 0.18 11.8 1.9 0.29 11.2 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF768) Hat1_N PF10394.9 ORX72605.1 - 6.4e-35 120.7 0.9 2.8e-32 112.2 0.9 2.5 1 1 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ORX72605.1 - 2e-05 24.8 0.0 4.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX72605.1 - 0.011 16.2 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX72605.1 - 0.018 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ank_4 PF13637.6 ORX72606.1 - 2.3e-08 34.4 0.0 0.0058 17.2 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX72606.1 - 0.00017 21.8 0.0 0.028 14.9 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 ORX72606.1 - 0.00019 21.9 0.0 0.00092 19.8 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX72606.1 - 0.0006 20.1 0.0 0.36 11.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ORX72606.1 - 0.0009 19.5 0.0 0.0079 16.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Lactamase_B_2 PF12706.7 ORX72607.1 - 4.2e-23 81.9 0.4 1.9e-21 76.5 0.4 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX72607.1 - 2.8e-11 43.6 0.1 4.1e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain 4HBT PF03061.22 ORX72608.1 - 4e-10 39.9 0.1 8e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 ORX72608.1 - 0.019 15.2 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Thioesterase-like superfamily DUF5549 PF17703.1 ORX72609.1 - 0.13 12.0 0.1 0.16 11.6 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5549) Rep_fac-A_3 PF08661.11 ORX72611.1 - 0.073 13.4 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Replication factor A protein 3 CDP-OH_P_transf PF01066.21 ORX72612.1 - 1.4e-13 51.3 0.7 3.1e-13 50.3 0.0 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TFIIB PF00382.19 ORX72613.1 - 6.5e-36 122.2 1.3 7.5e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ORX72613.1 - 6.4e-15 54.4 1.3 1.1e-14 53.7 1.3 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 ORX72613.1 - 0.0039 16.9 0.2 0.042 13.6 0.0 2.0 1 1 1 2 2 2 1 Cyclin, N-terminal domain ASL_C PF08328.11 ORX72613.1 - 0.02 15.0 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal TFIIB PF00382.19 ORX72614.1 - 5.6e-22 77.6 0.5 6.7e-15 54.9 0.3 3.3 2 1 0 2 2 2 2 Transcription factor TFIIB repeat ABC1 PF03109.16 ORX72615.1 - 5.7e-23 81.3 0.0 3.6e-22 78.7 0.0 2.0 1 1 1 2 2 2 1 ABC1 family RIO1 PF01163.22 ORX72615.1 - 0.0026 17.4 0.0 0.0082 15.8 0.0 1.8 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 ORX72615.1 - 0.0039 16.5 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF3501 PF12007.8 ORX72615.1 - 0.19 11.7 0.1 0.33 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3501) APH PF01636.23 ORX72615.1 - 0.21 11.5 3.6 0.24 11.3 0.4 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family HAD PF12710.7 ORX72616.1 - 3e-13 50.6 0.0 6.6e-13 49.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ORX72616.1 - 2.4e-07 30.4 0.2 1e-06 28.3 0.2 1.9 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.6 ORX72616.1 - 0.0036 17.4 1.0 0.17 12.0 1.0 2.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX72616.1 - 0.0044 17.3 0.3 0.013 15.8 0.3 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ORX72616.1 - 0.03 13.8 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) Ureidogly_lyase PF04115.12 ORX72617.1 - 2.4e-49 167.6 0.0 2.9e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase DUF4473 PF14747.6 ORX72619.1 - 0.0072 16.9 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4473) Baculo_PEP_C PF04513.12 ORX72623.1 - 0.091 12.8 0.3 0.13 12.3 0.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PI3_PI4_kinase PF00454.27 ORX72627.1 - 1.1e-20 74.5 0.0 1.5e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DIM PF08194.12 ORX72628.1 - 0.18 12.1 1.5 0.19 11.9 0.2 1.8 2 0 0 2 2 2 0 DIM protein WD40 PF00400.32 ORX72630.1 - 2.4e-40 135.7 20.5 1.1e-08 35.5 0.3 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72630.1 - 2.8e-19 69.2 2.3 2.3e-06 27.8 0.1 6.4 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX72630.1 - 0.039 12.9 0.1 1.4 7.8 0.1 2.9 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX72630.1 - 0.061 12.6 0.0 2.1 7.6 0.0 2.8 2 2 0 2 2 2 0 WD40-like domain RRM_1 PF00076.22 ORX72631.1 - 5.4e-13 48.6 0.0 8.6e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin PF00085.20 ORX72632.1 - 3.5e-27 94.4 0.0 4.3e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX72632.1 - 2.4e-08 34.4 0.2 2.4e-06 28.0 0.2 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ORX72632.1 - 5.3e-06 26.2 0.0 6e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ORX72632.1 - 3.4e-05 24.1 0.0 0.00072 19.8 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ORX72632.1 - 0.00029 20.8 0.0 0.00042 20.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 ORX72632.1 - 0.0055 16.9 0.1 0.0096 16.1 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 ORX72632.1 - 0.03 14.1 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_5 PF13743.6 ORX72632.1 - 0.062 13.0 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 ORX72632.1 - 0.076 13.4 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) BING4CT PF08149.11 ORX72633.1 - 1.4e-37 127.4 0.0 1.3e-33 114.6 0.0 2.9 2 0 0 2 2 2 2 BING4CT (NUC141) domain WD40 PF00400.32 ORX72633.1 - 2.6e-07 31.2 0.2 0.00042 21.1 0.0 5.1 5 1 1 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72633.1 - 3.3e-07 30.5 0.2 0.22 11.8 0.0 5.0 2 1 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 ORX72633.1 - 0.00073 18.7 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region Nbas_N PF15492.6 ORX72633.1 - 0.036 13.4 0.0 0.28 10.5 0.0 2.1 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal ABC_membrane PF00664.23 ORX72634.1 - 9.9e-64 215.6 3.8 1.3e-63 215.3 3.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX72634.1 - 1.5e-19 70.8 0.0 4e-19 69.5 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ORX72634.1 - 0.0037 17.0 0.4 0.012 15.4 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX72634.1 - 0.045 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 ORX72634.1 - 0.051 13.1 0.2 2.6 7.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX72634.1 - 0.055 13.9 0.0 0.16 12.3 0.0 1.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ORX72634.1 - 0.07 12.8 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ORX72634.1 - 0.091 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_22 PF13401.6 ORX72634.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 ORX72634.1 - 0.14 11.6 0.1 4.6 6.6 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF4231 PF14015.6 ORX72636.1 - 0.073 13.6 0.8 7 7.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Clc-like PF07062.12 ORX72636.1 - 0.17 11.3 0.5 0.42 10.1 0.0 1.7 1 1 0 1 1 1 0 Clc-like Nuf2 PF03800.14 ORX72637.1 - 3.2e-25 88.9 8.3 1.1e-24 87.1 1.4 3.3 2 2 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 ORX72637.1 - 5.8e-14 52.1 18.2 5.8e-14 52.1 18.2 4.1 1 1 3 4 4 4 2 Designed helical repeat protein 10 domain DUF812 PF05667.11 ORX72637.1 - 0.00064 18.7 28.3 0.00064 18.7 28.3 2.2 1 1 1 2 2 1 1 Protein of unknown function (DUF812) TolA_bind_tri PF16331.5 ORX72637.1 - 0.00073 19.6 4.6 0.00073 19.6 4.6 4.5 2 1 1 4 4 4 2 TolA binding protein trimerisation ATG16 PF08614.11 ORX72637.1 - 0.0008 19.7 15.7 0.0008 19.7 15.7 3.3 1 1 2 3 3 2 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.19 ORX72637.1 - 0.0019 16.2 38.4 0.003 15.4 38.4 1.3 1 0 0 1 1 1 1 Myosin tail Spc7 PF08317.11 ORX72637.1 - 0.0025 16.8 9.2 0.0025 16.8 9.2 3.1 1 1 2 3 3 3 2 Spc7 kinetochore protein DUF2968 PF11180.8 ORX72637.1 - 0.0026 17.4 14.2 0.0026 17.4 14.2 3.1 1 1 2 3 3 2 1 Protein of unknown function (DUF2968) Trimer_CC PF08954.11 ORX72637.1 - 0.015 14.8 4.7 0.89 9.2 0.3 3.6 3 0 0 3 3 3 0 Trimerisation motif Fez1 PF06818.15 ORX72637.1 - 0.015 15.7 17.0 0.015 15.7 17.0 2.2 1 1 1 2 2 2 0 Fez1 CLZ PF16526.5 ORX72637.1 - 0.02 15.2 0.4 0.02 15.2 0.4 5.1 2 2 4 6 6 6 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 ORX72637.1 - 0.063 13.3 26.0 2.8 8.0 6.7 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF3130 PF11328.8 ORX72637.1 - 0.077 13.3 0.2 0.077 13.3 0.2 2.6 2 2 1 4 4 2 0 Protein of unknown function (DUF3130 Vps4_C PF09336.10 ORX72637.1 - 0.12 12.4 0.1 1.1 9.3 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Fib_alpha PF08702.10 ORX72637.1 - 0.22 11.7 31.5 0.81 9.9 3.6 3.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 ORX72637.1 - 0.45 9.3 39.1 0.065 12.1 23.3 3.0 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3584 PF12128.8 ORX72637.1 - 0.66 7.4 42.9 1.9 5.9 42.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 ORX72637.1 - 0.93 9.5 14.1 0.64 10.1 3.9 3.5 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 ORX72637.1 - 1.2 9.2 24.5 0.26 11.4 1.0 4.0 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 ORX72637.1 - 1.4 9.6 29.5 2.9 8.6 6.4 4.7 1 1 3 4 4 4 0 Initiation control protein YabA Occludin_ELL PF07303.13 ORX72637.1 - 1.6 9.5 30.2 1.5 9.6 6.2 4.3 1 1 3 4 4 4 0 Occludin homology domain BLOC1_2 PF10046.9 ORX72637.1 - 2.2 8.6 28.2 0.18 12.1 1.7 4.9 1 1 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.6 ORX72637.1 - 2.3 6.8 35.9 2.4 6.7 13.1 2.6 1 1 1 2 2 2 0 AAA domain Sec34 PF04136.15 ORX72637.1 - 2.3 8.1 21.5 0.16 11.8 1.5 3.8 1 1 2 3 3 3 0 Sec34-like family DUF16 PF01519.16 ORX72637.1 - 2.6 8.6 30.7 0.23 12.0 7.1 4.3 1 1 2 3 3 3 0 Protein of unknown function DUF16 FUSC PF04632.12 ORX72637.1 - 3.5 6.0 22.2 0.59 8.6 9.6 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family PMEI PF04043.15 ORX72637.1 - 3.7 7.9 13.6 2.7 8.3 9.4 2.7 2 1 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DUF948 PF06103.11 ORX72637.1 - 4.4 7.6 12.3 2.2e+02 2.2 0.7 3.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 ORX72637.1 - 6.1 6.1 37.7 1.1 8.5 14.0 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) zf-C4H2 PF10146.9 ORX72637.1 - 8.9 6.6 33.6 0.57 10.5 15.5 2.6 1 1 1 2 2 1 0 Zinc finger-containing protein zf-MYND PF01753.18 ORX72638.1 - 1.4e-07 31.5 13.3 1.4e-07 31.5 13.3 2.4 2 0 0 2 2 2 1 MYND finger SET PF00856.28 ORX72638.1 - 7.4e-06 26.5 0.0 2.2e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 SET domain DPM2 PF07297.12 ORX72639.1 - 2.8e-25 88.4 1.4 3.4e-25 88.1 1.4 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 ORX72639.1 - 0.00049 20.0 0.4 0.00053 19.9 0.4 1.1 1 0 0 1 1 1 1 PIG-P Phage_holin_3_6 PF07332.11 ORX72639.1 - 0.052 13.6 1.1 0.058 13.4 1.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III COX14 PF14880.6 ORX72639.1 - 4.1 7.3 5.1 5.1 7.0 0.9 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c assembly WLM PF08325.10 ORX72640.1 - 2.3e-40 138.7 0.0 3.2e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 WLM domain ubiquitin PF00240.23 ORX72640.1 - 3.8e-07 29.8 0.0 9.5e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ORX72640.1 - 0.0013 19.1 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF45 PF01863.17 ORX72640.1 - 0.025 14.6 3.0 0.047 13.7 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Zincin_1 PF06262.11 ORX72640.1 - 0.19 11.8 1.1 0.4 10.8 0.3 1.9 2 0 0 2 2 2 0 Zincin-like metallopeptidase Mis14 PF08641.12 ORX72641.1 - 1.5e-08 35.0 5.2 7e-08 32.9 5.2 2.1 1 1 0 1 1 1 1 Kinetochore protein Mis14 like ApoLp-III PF07464.11 ORX72641.1 - 0.0034 17.5 3.6 0.12 12.5 0.5 2.4 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 ORX72641.1 - 0.011 15.8 0.6 0.64 10.0 0.1 2.5 2 0 0 2 2 2 0 Laminin Domain II CdvA PF18822.1 ORX72641.1 - 0.02 14.7 3.1 0.088 12.6 0.5 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain DUF948 PF06103.11 ORX72641.1 - 0.022 15.0 1.2 3.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_I PF06008.14 ORX72641.1 - 0.022 14.5 4.3 0.05 13.3 0.8 2.2 1 1 1 2 2 2 0 Laminin Domain I Rootletin PF15035.6 ORX72641.1 - 0.11 12.5 6.0 0.21 11.6 5.9 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ADSL_C PF10397.9 ORX72641.1 - 0.24 12.0 6.0 2.5 8.7 0.2 2.8 2 1 1 3 3 3 0 Adenylosuccinate lyase C-terminus HisKA PF00512.25 ORX72641.1 - 0.4 10.8 3.1 6.8 6.8 0.2 3.0 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF2203 PF09969.9 ORX72641.1 - 0.67 10.7 4.5 0.66 10.7 1.0 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Sec2p PF06428.11 ORX72641.1 - 2.9 7.9 7.4 0.7 9.9 3.2 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p YabA PF06156.13 ORX72641.1 - 3.9 8.2 5.0 8.2 7.1 0.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DUF4611 PF15387.6 ORX72641.1 - 4.3 7.6 8.2 6 7.2 2.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) YidC_periplas PF14849.6 ORX72642.1 - 0.003 17.5 0.0 0.0032 17.4 0.0 1.1 1 0 0 1 1 1 1 YidC periplasmic domain 4HBT PF03061.22 ORX72642.1 - 0.087 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Thioesterase superfamily DUF1177 PF06675.11 ORX72644.1 - 0.023 13.6 0.2 0.043 12.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1177) BOF PF04076.13 ORX72644.1 - 0.034 14.2 0.1 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein DUF572 PF04502.13 ORX72645.1 - 9.8e-30 104.3 1.5 2.5e-21 76.7 0.0 2.1 1 1 1 2 2 2 2 Family of unknown function (DUF572) DEAD PF00270.29 ORX72647.1 - 2e-42 144.9 0.5 3.7e-42 144.1 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX72647.1 - 3.7e-32 111.0 1.0 9.5e-31 106.4 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX72647.1 - 2.3e-07 31.0 0.0 5.5e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ORX72647.1 - 2.1e-05 23.4 0.1 3.5e-05 22.7 0.1 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_19 PF13245.6 ORX72647.1 - 0.0018 18.6 0.1 0.0034 17.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX72647.1 - 0.021 15.1 0.1 0.063 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 ORX72647.1 - 0.037 14.0 0.1 0.094 12.7 0.1 1.7 1 0 0 1 1 1 0 Flavivirus DEAD domain UTP25 PF06862.12 ORX72647.1 - 0.05 12.4 0.0 0.11 11.2 0.0 1.6 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Helicase_C_2 PF13307.6 ORX72647.1 - 0.096 12.8 0.0 0.44 10.7 0.0 2.0 2 0 0 2 2 2 0 Helicase C-terminal domain SYF2 PF08231.12 ORX72648.1 - 1e-22 81.2 14.1 2.8e-22 79.8 14.1 1.6 1 1 0 1 1 1 1 SYF2 splicing factor DUF5133 PF17196.4 ORX72648.1 - 0.9 9.8 3.1 8.9 6.6 0.1 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF5133) CTP_synth_N PF06418.14 ORX72649.1 - 1.3e-124 414.8 0.0 1.7e-124 414.4 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ORX72649.1 - 2.1e-57 194.0 0.0 3.8e-57 193.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX72649.1 - 1.7e-05 24.7 0.1 5.4e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 Phage_lysozyme PF00959.19 ORX72650.1 - 3.3e-12 46.8 0.0 4.7e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX72650.1 - 0.00032 20.9 0.1 0.00093 19.4 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_3 PF08239.11 ORX72651.1 - 0.0018 18.5 0.0 0.0038 17.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Neisseria_TspB PF05616.13 ORX72651.1 - 0.0046 15.5 1.1 0.006 15.1 1.1 1.1 1 0 0 1 1 1 1 Neisseria meningitidis TspB protein Exo84_C PF16528.5 ORX72652.1 - 6.5e-45 153.5 0.0 1.3e-44 152.5 0.0 1.5 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ORX72652.1 - 1.3e-13 50.8 0.6 3.2e-13 49.5 0.6 1.7 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ORX72652.1 - 3.5e-07 30.4 2.5 3.5e-07 30.4 0.7 1.9 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 BMFP PF04380.13 ORX72652.1 - 0.012 16.1 1.3 0.03 14.8 0.3 2.3 2 0 0 2 2 2 0 Membrane fusogenic activity PRP38 PF03371.15 ORX72652.1 - 0.12 12.2 0.8 5.9 6.7 0.1 2.3 2 0 0 2 2 2 0 PRP38 family Abhydrolase_6 PF12697.7 ORX72654.1 - 2.5e-25 90.4 4.1 3.1e-25 90.1 4.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX72654.1 - 5.4e-11 42.2 2.5 8.2e-11 41.6 1.7 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ORX72654.1 - 1.2e-09 38.6 0.1 9e-09 35.8 0.1 1.9 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_1 PF00561.20 ORX72654.1 - 2.9e-09 36.9 0.6 7.1e-08 32.4 0.7 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 ORX72654.1 - 0.00016 21.5 0.1 0.00024 20.9 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.16 ORX72654.1 - 0.0013 18.5 0.5 0.37 10.6 0.0 2.7 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.7 ORX72654.1 - 0.011 15.5 0.1 0.019 14.7 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family LIDHydrolase PF10230.9 ORX72654.1 - 0.021 14.4 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 ORX72654.1 - 0.027 14.3 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 ORX72654.1 - 0.058 13.2 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 ORX72654.1 - 0.07 13.0 0.7 0.18 11.7 0.4 1.8 1 1 1 2 2 2 0 Serine hydrolase Chlorophyllase2 PF12740.7 ORX72654.1 - 0.14 11.1 0.2 0.23 10.3 0.2 1.4 1 1 0 1 1 1 0 Chlorophyllase enzyme Esterase PF00756.20 ORX72654.1 - 0.16 11.6 0.1 0.31 10.6 0.1 1.4 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 ORX72655.1 - 1.6e-21 76.7 1.8 2.6e-16 59.6 2.2 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX72655.1 - 2.6e-11 43.7 0.1 3.5e-11 43.2 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX72655.1 - 0.0001 23.0 0.0 0.00011 22.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX72655.1 - 0.069 12.6 0.6 0.08 12.4 0.6 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family Voltage_CLC PF00654.20 ORX72657.1 - 4.2e-44 151.2 28.1 4.9e-43 147.7 24.6 3.3 2 1 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ORX72657.1 - 4.6e-07 30.2 0.5 1.2e-06 28.9 0.1 1.9 2 0 0 2 2 2 1 CBS domain SMC_N PF02463.19 ORX72658.1 - 1.7e-69 233.6 0.3 2.4e-69 233.1 0.3 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX72658.1 - 1.1e-18 67.6 0.0 1.7e-16 60.5 0.0 3.0 1 1 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 ORX72658.1 - 1.9e-17 64.0 0.2 1.4e-08 34.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ORX72658.1 - 3.7e-16 59.8 0.4 1.5e-08 34.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX72658.1 - 7e-14 52.8 6.0 7e-14 52.8 6.0 5.6 3 2 0 3 3 3 1 AAA domain BLOC1_2 PF10046.9 ORX72658.1 - 0.017 15.4 0.7 0.017 15.4 0.7 7.0 6 2 1 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_29 PF13555.6 ORX72658.1 - 0.026 14.3 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ORX72658.1 - 0.047 14.2 13.9 0.58 10.7 1.7 5.2 2 2 0 2 2 2 0 ABC transporter ThiS PF02597.20 ORX72658.1 - 0.54 10.9 0.1 0.54 10.9 0.1 4.0 3 0 0 3 3 3 0 ThiS family NleF_casp_inhib PF16809.5 ORX72658.1 - 1.2 9.1 9.8 0.19 11.6 1.5 3.6 4 0 0 4 4 4 0 NleF caspase inhibitor TPR_1 PF00515.28 ORX72661.1 - 2.3e-09 36.7 11.2 0.0056 16.5 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX72661.1 - 2.6e-08 33.4 8.8 0.0092 16.0 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat PB1 PF00564.24 ORX72661.1 - 3.8e-06 26.7 0.0 7.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_11 PF13414.6 ORX72661.1 - 0.0038 16.9 0.2 2.8 7.7 0.0 3.2 2 1 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 ORX72661.1 - 0.0077 16.5 7.2 0.2 12.0 0.5 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX72661.1 - 0.1 13.0 0.5 18 6.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.10 ORX72661.1 - 0.18 10.6 0.4 0.28 10.0 0.4 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) TPR_16 PF13432.6 ORX72661.1 - 0.26 12.0 0.2 0.26 12.0 0.2 3.3 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX72661.1 - 0.33 11.1 1.9 1.2e+02 3.1 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX72661.1 - 0.65 10.3 10.9 5.6 7.5 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX72661.1 - 5.7 7.8 12.9 42 5.1 0.2 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat Y_phosphatase PF00102.27 ORX72662.1 - 4.8e-75 252.1 0.0 5.8e-75 251.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ORX72662.1 - 0.0029 17.4 0.0 0.0055 16.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ORX72662.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family JmjC PF02373.22 ORX72663.1 - 1.6e-21 76.8 2.3 2.7e-21 76.1 2.3 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ORX72663.1 - 3e-18 66.4 3.7 4.7e-18 65.8 3.7 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ORX72663.1 - 0.0015 18.2 0.1 0.0051 16.5 0.0 1.9 2 0 0 2 2 2 1 Cupin domain E1-E2_ATPase PF00122.20 ORX72664.1 - 8.4e-51 172.1 0.3 8.4e-51 172.1 0.3 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ORX72664.1 - 3.8e-24 86.2 0.2 7.7e-24 85.2 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ORX72664.1 - 1.3e-19 70.6 6.3 1.9e-19 70.1 0.1 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 ORX72664.1 - 1.9e-13 49.9 0.0 4.4e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX72664.1 - 6.7e-13 48.5 0.0 1.5e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX72664.1 - 8.7e-05 22.4 0.8 0.00062 19.6 0.9 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sensor_TM1 PF13755.6 ORX72664.1 - 0.05 13.3 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain DUF2127 PF09900.9 ORX72664.1 - 0.39 11.0 3.1 0.63 10.3 0.6 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2127) AA_kinase PF00696.28 ORX72665.1 - 2e-35 122.6 0.3 2.9e-35 122.0 0.3 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 ORX72665.1 - 2.9e-09 36.8 0.5 9.4e-09 35.1 0.5 1.9 1 0 0 1 1 1 1 PUA domain Sdh5 PF03937.16 ORX72666.1 - 2.3e-23 81.9 0.4 3.5e-23 81.3 0.4 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase DUF1967 PF09269.11 ORX72666.1 - 0.091 12.7 0.1 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) DHHA2 PF02833.14 ORX72667.1 - 4.5e-25 88.5 0.7 7.5e-25 87.8 0.7 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 ORX72667.1 - 1.3e-09 38.2 0.0 2.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 DHH family SERTA PF06031.13 ORX72668.1 - 0.056 13.1 0.2 0.22 11.2 0.2 1.9 1 1 0 1 1 1 0 SERTA motif DUF5073 PF16817.5 ORX72670.1 - 0.027 14.5 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5073) DUF2845 PF11006.8 ORX72670.1 - 0.15 12.2 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) DUF4051 PF13260.6 ORX72670.1 - 0.36 10.6 2.9 0.18 11.6 0.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) CBM_21 PF03370.13 ORX72672.1 - 2.6e-29 101.7 0.0 4e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ORX72672.1 - 9.6e-13 48.5 0.0 1.7e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) PNP_UDP_1 PF01048.20 ORX72674.1 - 1.3e-26 93.4 0.0 1.5e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Peptidase_S49_N PF08496.10 ORX72675.1 - 5.4 7.1 12.2 8.6 6.4 5.1 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Mak16 PF04874.14 ORX72675.1 - 8 7.1 7.4 81 3.9 3.6 2.5 2 0 0 2 2 2 0 Mak16 protein C-terminal region HARE-HTH PF05066.13 ORX72676.1 - 0.019 15.3 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 HB1, ASXL, restriction endonuclease HTH domain Raf1_N PF18578.1 ORX72677.1 - 0.029 14.9 1.9 0.042 14.3 0.8 1.8 2 0 0 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain HPP PF04982.13 ORX72680.1 - 1.5e-38 131.7 11.0 1.5e-38 131.7 11.0 1.4 2 0 0 2 2 2 1 HPP family RNase_H PF00075.24 ORX72681.1 - 9.8e-27 93.9 0.0 1.1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ORX72681.1 - 0.0029 17.4 0.2 0.0064 16.3 0.2 1.8 1 1 0 1 1 1 1 Reverse transcriptase-like OTCace PF00185.24 ORX72681.1 - 0.11 12.5 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ApbA PF02558.16 ORX72682.1 - 4.7e-30 104.2 0.0 6.7e-30 103.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX72682.1 - 4.3e-20 72.2 0.0 7.6e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DAO PF01266.24 ORX72682.1 - 0.011 15.3 0.7 0.023 14.3 0.6 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Sacchrp_dh_NADP PF03435.18 ORX72682.1 - 0.054 13.7 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1899 PF08953.11 ORX72684.1 - 2.5e-29 101.0 0.1 4.8e-29 100.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 ORX72684.1 - 4.5e-18 64.9 0.1 4.5e-18 64.9 0.1 1.8 2 0 0 2 2 1 1 Type of WD40 repeat WD40 PF00400.32 ORX72684.1 - 9.8e-15 54.7 2.6 0.0014 19.4 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72684.1 - 7e-11 42.3 0.1 0.00011 22.4 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.11 ORX72684.1 - 8e-05 23.0 8.5 0.00013 22.3 8.5 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) VID27 PF08553.10 ORX72684.1 - 0.0006 19.0 0.0 0.00091 18.4 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain Nup160 PF11715.8 ORX72684.1 - 0.012 14.3 0.2 1.7 7.2 0.1 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Leu_zip PF15294.6 ORX72684.1 - 0.015 14.8 4.3 0.022 14.3 4.3 1.1 1 0 0 1 1 1 0 Leucine zipper DUF2046 PF09755.9 ORX72684.1 - 0.022 14.0 6.1 0.032 13.5 6.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) TBCA PF02970.16 ORX72684.1 - 0.028 14.8 2.4 0.028 14.8 2.4 2.1 2 0 0 2 2 2 0 Tubulin binding cofactor A TMF_TATA_bd PF12325.8 ORX72684.1 - 0.033 14.4 4.8 0.064 13.5 4.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Rab5-bind PF09311.11 ORX72684.1 - 0.04 13.3 10.1 0.059 12.8 10.1 1.1 1 0 0 1 1 1 0 Rabaptin-like protein Jnk-SapK_ap_N PF09744.9 ORX72684.1 - 0.05 13.8 11.2 0.076 13.2 11.2 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TolA_bind_tri PF16331.5 ORX72684.1 - 0.064 13.3 15.1 0.99 9.5 0.8 3.4 1 1 2 3 3 3 0 TolA binding protein trimerisation DUF737 PF05300.11 ORX72684.1 - 0.099 13.0 9.4 0.17 12.2 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) Hamartin PF04388.12 ORX72684.1 - 0.15 10.7 7.2 0.21 10.2 7.2 1.1 1 0 0 1 1 1 0 Hamartin protein FlxA PF14282.6 ORX72684.1 - 0.43 10.6 14.0 0.51 10.4 13.4 1.4 1 1 0 1 1 1 0 FlxA-like protein EzrA PF06160.12 ORX72684.1 - 0.45 8.6 5.7 0.6 8.2 5.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Seryl_tRNA_N PF02403.22 ORX72684.1 - 0.6 10.4 7.3 0.74 10.1 5.3 2.1 2 1 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain Golgin_A5 PF09787.9 ORX72684.1 - 0.87 9.0 8.4 1.3 8.4 8.4 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 ORX72684.1 - 5.7 6.2 15.0 9 5.5 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ORX72684.1 - 6.2 5.6 12.9 9.1 5.1 12.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 ORX72684.1 - 6.4 6.8 12.2 0.93 9.6 5.5 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ARGLU PF15346.6 ORX72684.1 - 7.7 6.4 10.7 11 5.9 9.7 1.7 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 ApbA_C PF08546.11 ORX72685.1 - 1.6e-15 57.4 0.0 2.6e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ORX72685.1 - 5.7e-05 22.8 0.0 0.016 14.8 0.0 2.3 1 1 1 2 2 2 2 Ketopantoate reductase PanE/ApbA ApbA PF02558.16 ORX72686.1 - 8.6e-26 90.4 0.0 1.4e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX72686.1 - 9.3e-25 87.2 0.0 1.9e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ORX72687.1 - 5.1e-28 97.6 0.0 7.3e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX72687.1 - 3.9e-08 33.6 0.1 7e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal GFO_IDH_MocA PF01408.22 ORX72687.1 - 0.053 14.4 0.0 0.14 13.0 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold GARS_N PF02844.15 ORX72687.1 - 0.069 13.9 0.0 0.17 12.7 0.0 1.7 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain ThiF PF00899.21 ORX72687.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 ThiF family PglD_N PF17836.1 ORX72687.1 - 0.13 13.0 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 PglD N-terminal domain CHCH PF06747.13 ORX72688.1 - 2.5e-08 33.8 5.1 8.4e-08 32.2 5.1 2.0 1 0 0 1 1 1 1 CHCH domain GEN1_C PF18380.1 ORX72688.1 - 0.057 14.3 1.7 0.057 14.3 1.7 2.1 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Presenilin PF01080.17 ORX72688.1 - 0.66 8.7 5.3 0.74 8.5 5.3 1.1 1 0 0 1 1 1 0 Presenilin GCK PF07802.11 ORX72688.1 - 3 8.3 11.2 0.051 14.0 4.1 1.8 2 0 0 2 2 2 0 GCK domain ATP-synt_E PF05680.12 ORX72688.1 - 3.7 8.0 7.9 0.17 12.2 1.4 1.9 2 0 0 2 2 2 0 ATP synthase E chain FAM176 PF14851.6 ORX72688.1 - 5.9 6.5 13.7 0.45 10.2 1.9 2.1 2 0 0 2 2 2 0 FAM176 family adh_short PF00106.25 ORX72689.1 - 1.2e-40 139.0 1.5 1.5e-40 138.8 1.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX72689.1 - 6.7e-28 97.8 0.6 8.1e-28 97.6 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX72689.1 - 7.7e-06 25.9 1.3 9.7e-06 25.6 1.2 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX72689.1 - 4.1e-05 23.2 0.2 0.0016 17.9 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX72689.1 - 0.059 12.7 0.3 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Methyltransf_31 PF13847.6 ORX72689.1 - 0.068 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF1776 PF08643.10 ORX72689.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 1 1 2 2 2 0 Fungal family of unknown function (DUF1776) DUF1694 PF07997.11 ORX72689.1 - 0.15 12.1 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) AIM24 PF01987.17 ORX72690.1 - 4.7e-24 85.3 0.0 7.5e-24 84.6 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 Transferase PF02458.15 ORX72691.1 - 2.1e-24 86.0 0.0 2.1e-23 82.7 0.0 2.0 2 0 0 2 2 2 1 Transferase family DUF2773 PF10971.8 ORX72691.1 - 0.022 14.9 0.0 0.093 12.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) ChaC PF04752.12 ORX72692.1 - 2.3e-51 174.4 0.0 2.8e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein ENTH PF01417.20 ORX72693.1 - 1.5e-41 141.3 0.1 2.5e-41 140.7 0.1 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ORX72693.1 - 5.1e-07 29.0 0.0 7.6e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 ORX72693.1 - 0.0041 17.0 0.0 0.0073 16.2 0.0 1.3 1 0 0 1 1 1 1 VHS domain MAS20 PF02064.15 ORX72693.1 - 3.8 7.6 6.9 12 6.0 6.9 1.8 1 0 0 1 1 1 0 MAS20 protein import receptor UIM PF02809.20 ORX72693.1 - 7.8 6.7 12.7 5.1 7.3 3.2 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif APG17 PF04108.12 ORX72694.1 - 7.5e-34 117.5 0.0 9.8e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg17 Peripla_BP_3 PF13377.6 ORX72694.1 - 0.0014 19.0 0.2 0.0022 18.4 0.2 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain DUF4398 PF14346.6 ORX72694.1 - 0.097 13.3 1.2 0.097 13.3 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) E1-E2_ATPase PF00122.20 ORX72695.1 - 6.7e-26 90.9 7.1 3.1e-25 88.7 0.4 4.2 3 2 1 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ORX72695.1 - 2.5e-19 70.4 0.5 5.2e-19 69.4 0.5 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX72695.1 - 1.4e-12 47.1 0.2 4.6e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX72695.1 - 0.00016 21.5 0.9 0.002 17.9 0.6 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX72695.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Spindle_Spc25 PF08234.12 ORX72699.1 - 6.1e-20 71.2 0.1 1.3e-19 70.1 0.1 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 ATG16 PF08614.11 ORX72699.1 - 0.0071 16.6 21.0 1.4 9.1 20.3 2.5 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ORX72699.1 - 0.055 12.3 17.4 0.082 11.8 17.0 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Ku_C PF03730.14 ORX72699.1 - 0.058 14.1 7.4 0.25 12.0 7.4 2.1 1 1 0 1 1 1 0 Ku70/Ku80 C-terminal arm ECM11 PF15463.6 ORX72699.1 - 0.26 11.8 9.8 0.63 10.6 0.9 2.4 2 0 0 2 2 2 0 Extracellular mutant protein 11 HIP1_clath_bdg PF16515.5 ORX72699.1 - 4.6 7.9 20.3 2.5 8.8 12.5 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FUSC PF04632.12 ORX72699.1 - 7.7 4.9 5.6 10 4.5 5.6 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-HC5HC2H PF13771.6 ORX72700.1 - 5.2e-11 42.6 4.9 1.2e-10 41.5 4.9 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX72700.1 - 3.3e-10 40.1 3.7 3.3e-10 40.1 3.7 1.8 2 0 0 2 2 2 1 PHD-zinc-finger like domain PHD PF00628.29 ORX72700.1 - 0.014 15.3 4.3 0.014 15.3 4.3 3.2 3 0 0 3 3 3 0 PHD-finger MBT PF02820.18 ORX72701.1 - 5.9e-10 39.4 1.3 0.14 12.6 0.1 3.8 3 0 0 3 3 3 3 mbt repeat Tudor-knot PF11717.8 ORX72701.1 - 2.4e-08 33.7 15.3 0.0019 18.0 1.1 3.8 3 0 0 3 3 3 3 RNA binding activity-knot of a chromodomain SAWADEE PF16719.5 ORX72701.1 - 0.0011 19.0 7.1 2.2 8.3 0.1 3.5 3 1 0 3 3 3 3 SAWADEE domain RD3 PF14473.6 ORX72701.1 - 0.085 12.7 0.6 0.16 11.8 0.6 1.3 1 0 0 1 1 1 0 RD3 protein vATP-synt_E PF01991.18 ORX72701.1 - 0.46 9.9 4.7 0.7 9.3 4.7 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Transferase PF02458.15 ORX72703.1 - 8.1e-19 67.6 0.0 1e-17 63.9 0.0 2.1 1 1 0 1 1 1 1 Transferase family CDC37_N PF03234.14 ORX72704.1 - 2e-30 106.4 5.6 2.2e-30 106.2 5.6 1.0 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding CEP209_CC5 PF16574.5 ORX72704.1 - 0.041 14.1 5.7 0.058 13.6 5.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 DUF4747 PF15931.5 ORX72704.1 - 0.064 12.9 0.6 0.093 12.4 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4747) DUF3782 PF12644.7 ORX72704.1 - 0.067 13.3 3.5 0.093 12.9 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) CDC37_M PF08565.11 ORX72705.1 - 2.3e-28 98.5 0.0 3.5e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 ORX72705.1 - 3.1e-14 52.9 0.1 6.8e-14 51.8 0.1 1.6 2 0 0 2 2 2 1 Cdc37 C terminal domain Ric8 PF10165.9 ORX72706.1 - 5.1e-38 131.3 4.9 2e-35 122.7 4.9 3.6 1 1 0 1 1 1 1 Guanine nucleotide exchange factor synembryn RPN13_C PF16550.5 ORX72706.1 - 0.05 13.8 0.0 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 UCH-binding domain vATP-synt_E PF01991.18 ORX72710.1 - 2e-25 89.4 11.1 3.5e-12 46.2 10.0 2.1 2 0 0 2 2 2 2 ATP synthase (E/31 kDa) subunit Hc1 PF07432.13 ORX72710.1 - 0.039 14.3 0.9 0.039 14.3 0.9 1.9 2 0 0 2 2 2 0 Histone H1-like protein Hc1 Speriolin_N PF15058.6 ORX72710.1 - 0.051 13.7 0.1 0.055 13.6 0.1 1.2 1 0 0 1 1 1 0 Speriolin N terminus YbbR PF07949.12 ORX72710.1 - 0.17 12.3 3.8 0.37 11.2 0.6 2.1 2 0 0 2 2 2 0 YbbR-like protein DUF883 PF05957.13 ORX72710.1 - 2.1 9.0 6.4 0.8 10.3 2.4 2.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) zf-C3HC4_2 PF13923.6 ORX72711.1 - 3.2e-11 42.9 7.6 4.7e-11 42.4 7.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX72711.1 - 1.1e-10 41.3 4.6 2.2e-10 40.4 4.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX72711.1 - 1.5e-10 40.8 6.2 2.3e-10 40.2 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX72711.1 - 6.6e-10 38.7 6.3 9.6e-10 38.2 6.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX72711.1 - 9.3e-10 38.7 9.0 1.4e-09 38.2 9.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ORX72711.1 - 4.7e-09 36.1 5.0 7.8e-09 35.4 5.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX72711.1 - 1.4e-07 31.3 8.8 2.3e-07 30.6 8.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ORX72711.1 - 7.1e-06 26.2 6.7 1.9e-05 24.9 6.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ORX72711.1 - 2e-05 24.6 8.1 4e-05 23.7 8.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ORX72711.1 - 0.033 14.0 1.6 0.053 13.3 1.6 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_IE-1 PF05290.11 ORX72711.1 - 0.044 13.7 4.6 0.072 13.0 4.6 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) U-box PF04564.15 ORX72711.1 - 0.048 13.8 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-RING_4 PF14570.6 ORX72711.1 - 0.092 12.6 5.6 0.21 11.4 5.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 ORX72711.1 - 0.11 12.1 8.2 0.22 11.2 8.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ORX72711.1 - 0.13 12.3 4.0 0.3 11.2 4.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 ORX72711.1 - 0.22 11.4 6.5 0.37 10.7 6.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 ORX72711.1 - 0.31 10.7 8.3 0.51 10.0 8.3 1.3 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_10 PF16685.5 ORX72711.1 - 2.2 8.5 6.4 3.3 7.9 6.4 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 IBR PF01485.21 ORX72711.1 - 6.2 7.1 10.6 1 9.6 6.0 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Spt20 PF12090.8 ORX72711.1 - 9.8 5.7 9.7 13 5.3 9.7 1.1 1 0 0 1 1 1 0 Spt20 family Lyase_1 PF00206.20 ORX72712.1 - 5.4e-82 275.7 0.0 6.2e-72 242.6 0.0 2.2 1 1 1 2 2 2 2 Lyase ASL_C2 PF14698.6 ORX72712.1 - 1.1e-23 83.8 0.0 2.4e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Ribosomal_L22 PF00237.19 ORX72713.1 - 1.1e-39 134.8 0.1 1.6e-39 134.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Mucin PF01456.17 ORX72715.1 - 0.0039 17.2 11.1 0.0044 17.0 11.1 1.1 1 0 0 1 1 1 1 Mucin-like glycoprotein SecG PF03840.14 ORX72715.1 - 0.5 10.5 0.1 0.5 10.5 0.1 1.8 2 0 0 2 2 2 0 Preprotein translocase SecG subunit HILPDA PF15220.6 ORX72715.1 - 2 8.6 4.9 0.89 9.7 0.9 2.1 1 1 1 2 2 2 0 Hypoxia-inducible lipid droplet-associated Big_1 PF02369.16 ORX72715.1 - 3.9 7.6 15.7 3.6 7.6 5.5 2.3 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 1) Endonuclease_NS PF01223.23 ORX72717.1 - 4.4e-58 196.8 0.0 5e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Peptidase_M20 PF01546.28 ORX72718.1 - 1e-24 87.4 0.0 1.3e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ORX72718.1 - 6e-08 32.6 0.0 9.6e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Oest_recep PF02159.15 ORX72718.1 - 0.011 16.3 0.1 0.76 10.3 0.0 2.3 2 0 0 2 2 2 0 Oestrogen receptor IGPS PF00218.21 ORX72719.1 - 2.1e-89 299.0 1.2 2.8e-89 298.7 1.2 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 ORX72719.1 - 7.6e-48 162.8 0.0 1.7e-47 161.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX72719.1 - 1.3e-08 34.9 0.1 4.6e-08 33.1 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 NanE PF04131.14 ORX72719.1 - 1.7e-06 27.4 0.9 8.5e-05 21.8 0.2 2.3 2 0 0 2 2 2 2 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.19 ORX72719.1 - 0.00025 20.9 0.5 0.00049 19.9 0.5 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain DHO_dh PF01180.21 ORX72719.1 - 0.0014 17.9 0.9 0.11 11.7 0.1 2.4 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase zf-C2H2_jaz PF12171.8 ORX72722.1 - 2.3e-05 24.5 3.1 0.04 14.2 0.3 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX72722.1 - 0.00012 22.7 1.5 0.067 14.1 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX72722.1 - 0.0065 16.9 0.8 3.7 8.2 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 ORX72722.1 - 0.0071 16.7 0.3 0.037 14.4 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ORX72722.1 - 0.045 13.8 1.2 0.38 10.8 0.4 2.3 1 1 1 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 ORX72722.1 - 0.061 13.6 2.3 0.23 11.8 2.4 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.22 ORX72722.1 - 0.078 13.2 2.4 0.15 12.3 2.4 1.4 1 0 0 1 1 1 0 LIM domain zf-C2H2_2 PF12756.7 ORX72722.1 - 0.19 12.1 3.5 2 8.8 0.2 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF629 PF04780.12 ORX72722.1 - 0.43 9.0 1.9 0.63 8.5 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Aldedh PF00171.22 ORX72723.1 - 8e-125 416.9 0.0 9.4e-125 416.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NOC3p PF07540.11 ORX72724.1 - 2.3e-26 92.1 0.1 9.5e-26 90.1 0.1 2.1 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 ORX72724.1 - 2.2e-15 57.1 0.2 2.2e-15 57.1 0.2 3.1 2 1 1 3 3 3 1 CBF/Mak21 family Spt20 PF12090.8 ORX72725.1 - 2.4e-24 86.2 0.0 7.1e-19 68.4 0.0 2.2 1 1 1 2 2 2 2 Spt20 family Med15 PF09606.10 ORX72726.1 - 0.23 10.1 41.6 0.24 10.0 41.6 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PhnI PF05861.12 ORX72726.1 - 1.3 7.8 7.5 1.6 7.5 7.5 1.0 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnI) Ubie_methyltran PF01209.18 ORX72727.1 - 7.4e-32 110.5 0.0 9.5e-32 110.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX72727.1 - 8.9e-19 67.9 0.0 1.4e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX72727.1 - 2e-18 66.9 0.0 3.7e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX72727.1 - 1.9e-12 47.2 0.0 2.7e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX72727.1 - 1.1e-11 44.9 0.0 1.3e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX72727.1 - 1.8e-09 38.2 0.0 3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX72727.1 - 0.00076 19.1 0.0 0.0016 18.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 ORX72727.1 - 0.0012 18.5 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 ORX72727.1 - 0.0051 16.7 0.0 0.008 16.0 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Cons_hypoth95 PF03602.15 ORX72727.1 - 0.088 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_24 PF13578.6 ORX72727.1 - 0.11 13.6 0.0 0.28 12.2 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase domain Inhibitor_I78 PF11720.8 ORX72727.1 - 0.16 12.1 0.1 0.36 10.9 0.1 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I78 family Ubie_methyltran PF01209.18 ORX72728.1 - 7.9e-35 120.3 0.0 8.4e-35 120.2 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ORX72728.1 - 7e-19 68.3 0.0 1.1e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX72728.1 - 1.9e-18 66.9 0.0 2.8e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX72728.1 - 8.4e-16 58.1 0.0 1e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX72728.1 - 8.2e-12 45.3 0.0 1e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX72728.1 - 3e-11 43.9 0.0 4.6e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX72728.1 - 0.00032 20.6 0.0 0.00044 20.2 0.0 1.3 1 1 0 1 1 1 1 Hypothetical methyltransferase UPF0020 PF01170.18 ORX72728.1 - 0.00044 20.0 0.0 0.00078 19.2 0.0 1.4 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_5 PF01795.19 ORX72728.1 - 0.00046 19.8 0.0 0.02 14.4 0.0 2.1 2 0 0 2 2 2 1 MraW methylase family MTS PF05175.14 ORX72728.1 - 0.0028 17.2 0.0 0.0043 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 ORX72728.1 - 0.0044 16.6 0.0 0.011 15.3 0.0 1.7 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 ORX72728.1 - 0.0068 15.7 0.0 0.0086 15.4 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_24 PF13578.6 ORX72728.1 - 0.019 16.0 0.0 0.031 15.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 ORX72728.1 - 0.16 11.9 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_46 PF01374.18 ORX72729.1 - 1e-37 129.8 8.3 4.6e-36 124.4 8.3 2.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 46 RRM_1 PF00076.22 ORX72730.1 - 4.9e-13 48.7 0.0 9.4e-13 47.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1177 PF06675.11 ORX72730.1 - 0.017 14.0 3.5 0.077 11.8 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1177) zf-CCCH_3 PF15663.5 ORX72731.1 - 5.4e-15 55.6 2.6 1.3e-14 54.3 2.6 1.6 1 0 0 1 1 1 1 Zinc-finger containing family zf_CCCH_4 PF18345.1 ORX72731.1 - 7.1e-07 29.1 11.0 2.6e-06 27.3 6.6 2.6 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 ORX72731.1 - 1.1e-05 25.2 15.3 2.3e-05 24.2 2.7 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PAM2 PF07145.15 ORX72731.1 - 0.00026 20.5 0.9 0.00075 19.0 0.9 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf-CCCH_4 PF18044.1 ORX72731.1 - 0.00042 20.1 4.8 0.00042 20.1 4.8 2.4 2 0 0 2 2 2 1 CCCH-type zinc finger Torus PF16131.5 ORX72731.1 - 0.024 15.3 2.3 0.024 15.3 2.3 2.6 2 1 1 3 3 3 0 Torus domain zf-CCCH_2 PF14608.6 ORX72731.1 - 0.3 11.6 14.0 2.5 8.7 2.5 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger WD40 PF00400.32 ORX72732.1 - 1.2e-16 60.7 0.4 1.1e-06 29.2 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72732.1 - 5.4e-09 36.2 0.0 0.094 13.0 0.0 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ORX72732.1 - 0.11 13.1 3.0 46 4.7 0.2 3.8 3 0 0 3 3 3 0 PQQ-like domain DUF1729 PF08354.10 ORX72734.1 - 2.5e-100 335.9 0.0 3.4e-98 328.8 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 ORX72734.1 - 6.9e-30 104.2 2.0 6.8e-16 58.5 0.3 2.5 1 1 1 2 2 2 2 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 ORX72734.1 - 1.6e-26 93.6 0.0 4.2e-26 92.2 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX72734.1 - 2.9e-24 86.1 0.8 6.6e-23 81.7 0.2 2.7 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.19 ORX72734.1 - 6.6e-18 64.5 0.2 3.4e-17 62.2 0.1 2.2 2 0 0 2 2 2 1 MaoC like domain Ketoacyl-synt_C PF02801.22 ORX72734.1 - 6.8e-13 48.7 0.0 1.8e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SAT PF16073.5 ORX72734.1 - 5.7e-12 45.9 0.0 1.1e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 ORX72734.1 - 2.1e-09 37.4 2.6 1.9e-05 24.5 0.0 3.0 3 1 1 4 4 4 2 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX72734.1 - 0.00071 19.2 0.8 0.16 11.5 0.0 2.7 3 0 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Transferase PF02458.15 ORX72735.1 - 0.00058 18.6 0.1 0.0006 18.6 0.1 1.0 1 0 0 1 1 1 1 Transferase family DUF3533 PF12051.8 ORX72736.1 - 4.4e-14 52.2 12.4 2.3e-06 26.8 9.3 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3533) DUF4246 PF14033.6 ORX72737.1 - 3.8e-135 451.5 0.0 4.4e-135 451.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ORX72737.1 - 0.041 14.3 0.0 0.088 13.2 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase ADH_N PF08240.12 ORX72738.1 - 1.4e-20 73.2 5.1 1.6e-20 73.0 3.6 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX72738.1 - 2.7e-17 63.0 0.3 6.9e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX72738.1 - 1.5e-06 27.7 0.1 2.5e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ORX72738.1 - 2.3e-06 27.1 0.3 8e-06 25.3 0.1 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 ORX72738.1 - 9.9e-05 23.4 0.0 0.00043 21.3 0.0 2.1 2 1 0 2 2 2 1 Zinc-binding dehydrogenase F420_oxidored PF03807.17 ORX72738.1 - 0.0063 17.1 0.2 0.095 13.3 0.2 2.3 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 ORX72738.1 - 0.039 14.8 0.0 0.077 13.8 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ELFV_dehydrog PF00208.21 ORX72738.1 - 0.049 13.3 0.1 0.086 12.6 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Kazal_1 PF00050.21 ORX72738.1 - 0.13 12.3 4.0 0.46 10.5 2.2 2.2 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain Lectin_leg-like PF03388.13 ORX72739.1 - 2.9e-61 206.8 0.0 3.1e-61 206.6 0.0 1.0 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 ORX72739.1 - 2.9e-08 34.0 3.7 3.8e-08 33.6 3.7 1.1 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 ORX72739.1 - 1.8e-07 31.0 0.0 6.3e-06 25.9 0.0 2.2 1 1 0 1 1 1 1 Legume lectin domain CAF1 PF04857.20 ORX72740.1 - 1.4e-78 264.3 0.0 1.7e-78 264.0 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease RBP_receptor PF14752.6 ORX72740.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor Dynamin_N PF00350.23 ORX72741.1 - 1.4e-17 64.3 1.1 5.4e-17 62.3 0.0 2.4 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ORX72741.1 - 5.3e-10 39.4 0.6 3.9e-09 36.6 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX72741.1 - 4.1e-06 26.5 0.3 0.011 15.3 0.3 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX72741.1 - 0.0015 18.4 0.5 1.6 8.6 0.1 3.1 1 1 1 2 2 2 2 RsgA GTPase cobW PF02492.19 ORX72741.1 - 0.0035 17.0 0.3 2.1 7.9 0.2 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 ORX72741.1 - 0.0086 15.2 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 ORX72741.1 - 0.012 15.4 0.1 0.039 13.7 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain FeoB_N PF02421.18 ORX72741.1 - 0.019 14.5 0.4 4.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 ORX72741.1 - 0.021 15.0 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX72741.1 - 0.021 14.3 0.1 0.77 9.2 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family TsaE PF02367.17 ORX72741.1 - 0.098 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF_assoc_2 PF08356.12 ORX72742.1 - 9.6e-09 35.1 0.0 1.8e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF-hand_7 PF13499.6 ORX72742.1 - 1.3e-05 25.5 0.2 2.5e-05 24.6 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ORX72742.1 - 2.9e-05 23.3 0.1 6.6e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ORX72742.1 - 0.00026 20.6 0.1 0.0007 19.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ORX72742.1 - 0.00046 19.5 0.1 0.0011 18.4 0.1 1.7 1 0 0 1 1 1 1 EF hand SPARC_Ca_bdg PF10591.9 ORX72742.1 - 0.0089 16.3 0.9 0.5 10.7 0.0 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF3449 PF11931.8 ORX72743.1 - 1.1e-72 243.7 1.5 1.5e-71 240.0 0.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 ORX72743.1 - 7.2e-11 42.5 5.8 3.2e-10 40.4 1.9 3.3 3 1 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 ORX72743.1 - 1.5e-10 41.1 3.4 1.6e-05 25.1 1.3 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX72743.1 - 4.2e-10 39.6 6.2 1.5e-07 31.5 1.8 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding SF3a60_bindingd PF12108.8 ORX72743.1 - 2.5e-08 33.6 0.9 2.5e-08 33.6 0.9 2.1 2 0 0 2 2 2 1 Splicing factor SF3a60 binding domain zf-C2H2_2 PF12756.7 ORX72743.1 - 2e-07 31.3 0.5 0.00031 21.0 0.1 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX72743.1 - 0.039 14.8 2.8 2.8 9.0 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger YlbE PF14003.6 ORX72743.1 - 0.076 13.5 1.2 0.48 10.9 0.3 2.8 3 0 0 3 3 3 0 YlbE-like protein zf-DBF PF07535.12 ORX72743.1 - 0.16 12.1 6.1 0.24 11.5 0.4 3.1 3 0 0 3 3 3 0 DBF zinc finger AKAP95 PF04988.12 ORX72743.1 - 0.79 9.9 4.9 2.3 8.4 1.2 2.6 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 ORX72743.1 - 4.9 7.8 7.6 20 5.9 1.8 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type NmrA PF05368.13 ORX72745.1 - 2.3e-10 40.5 0.0 2.8e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.15 ORX72746.1 - 4.5e-35 121.1 0.5 7.3e-35 120.5 0.5 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ORX72746.1 - 2.9e-33 114.7 0.0 4.6e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ORX72746.1 - 0.013 16.1 0.1 0.045 14.3 0.1 2.0 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HEAT_EZ PF13513.6 ORX72747.1 - 2e-20 72.8 12.5 1.3e-07 32.0 0.0 8.9 7 2 1 8 8 8 3 HEAT-like repeat HEAT PF02985.22 ORX72747.1 - 1.8e-15 55.7 18.4 0.011 15.9 0.0 9.1 10 0 0 10 10 9 5 HEAT repeat HEAT_2 PF13646.6 ORX72747.1 - 2.1e-11 44.1 3.3 0.12 12.8 0.1 7.3 5 3 3 8 8 8 4 HEAT repeats IBN_N PF03810.19 ORX72747.1 - 5.5e-08 32.6 0.0 1.8e-06 27.8 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 ORX72747.1 - 4.4e-06 27.2 0.1 0.45 11.2 0.0 5.7 4 2 4 8 8 7 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX72747.1 - 1.4e-05 25.2 0.5 4.6 7.3 0.0 4.4 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ORX72747.1 - 0.0034 17.4 11.9 10 6.3 0.0 6.8 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 ORX72747.1 - 0.0052 16.0 0.8 14 4.7 0.1 4.3 3 2 0 3 3 3 1 RNAPII transcription regulator C-terminal DUF3437 PF11919.8 ORX72747.1 - 0.026 14.4 0.3 46 4.0 0.0 4.9 5 1 1 6 6 6 0 Domain of unknown function (DUF3437) Xpo1 PF08389.12 ORX72747.1 - 0.028 14.5 0.8 0.32 11.1 0.0 3.0 2 1 0 2 2 2 0 Exportin 1-like protein HEAT_PBS PF03130.16 ORX72747.1 - 0.095 13.4 0.4 29 5.7 0.0 4.3 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat TPD52 PF04201.15 ORX72747.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Tumour protein D52 family CAP59_mtransfer PF11735.8 ORX72748.1 - 1.1e-23 84.1 0.0 1.8e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 HTH_3 PF01381.22 ORX72748.1 - 0.011 15.8 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix UPF0175 PF03683.13 ORX72748.1 - 0.15 11.8 0.0 0.4 10.4 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0175) MIF4G PF02854.19 ORX72749.1 - 1.1e-20 74.2 0.9 2.4e-20 73.1 0.9 1.6 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 ORX72749.1 - 2.4e-13 50.0 0.2 5.5e-12 45.7 0.0 2.8 2 1 0 2 2 2 1 MA3 domain POR PF01558.18 ORX72749.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Fapy_DNA_glyco PF01149.24 ORX72750.1 - 2.2e-16 60.5 0.0 3.8e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 ORX72750.1 - 6.6e-07 29.2 0.2 3.8e-05 23.6 0.5 2.2 1 1 1 2 2 2 2 Formamidopyrimidine-DNA glycosylase H2TH domain Amidohydro_1 PF01979.20 ORX72751.1 - 9.7e-64 215.8 0.0 9.9e-62 209.2 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX72751.1 - 2.2e-10 40.6 3.0 3.7e-08 33.3 0.1 2.5 2 1 0 3 3 3 2 Amidohydrolase family A_deaminase PF00962.22 ORX72751.1 - 0.028 13.8 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 Adenosine/AMP deaminase YEATS PF03366.16 ORX72754.1 - 8.4e-09 35.3 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 YEATS family DUF1664 PF07889.12 ORX72756.1 - 0.028 14.5 2.3 0.063 13.3 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3856 PF12968.7 ORX72756.1 - 0.032 14.3 0.0 0.076 13.1 0.0 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) Enoyl_reductase PF12241.8 ORX72756.1 - 0.052 12.9 0.0 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Trans-2-enoyl-CoA reductase catalytic region FMN_red PF03358.15 ORX72757.1 - 1.8e-14 53.8 0.0 2.5e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX72757.1 - 3.7e-09 36.6 0.0 5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX72757.1 - 0.0024 18.1 0.1 0.024 14.8 0.1 2.3 1 1 0 1 1 1 1 Flavodoxin Arrestin_N PF00339.29 ORX72759.1 - 4.6e-10 39.7 0.1 4.4e-09 36.6 0.1 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX72759.1 - 0.0015 19.0 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 ORX72759.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Arrestin_N terminal like UPF0542 PF15086.6 ORX72760.1 - 0.1 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 A_deaminase PF00962.22 ORX72761.1 - 6.3e-59 199.9 2.1 1.5e-56 192.1 2.1 3.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase CAP PF00188.26 ORX72762.1 - 0.00038 21.3 0.3 0.016 16.0 0.3 2.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family DUF2064 PF09837.9 ORX72762.1 - 0.041 13.7 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) SR-25 PF10500.9 ORX72762.1 - 1.7 8.2 6.8 2.4 7.7 6.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 ORX72762.1 - 8.7 6.9 7.3 1.6 9.3 2.5 2.0 2 0 0 2 2 2 0 Dehydrin CoA_transf_3 PF02515.17 ORX72763.1 - 1.1e-127 426.2 0.0 1.2e-127 426.0 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III SH3_1 PF00018.28 ORX72764.1 - 6.4e-13 48.1 0.1 7.3e-13 47.9 0.1 1.0 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX72764.1 - 6.8e-13 48.3 0.1 7.4e-13 48.1 0.1 1.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX72764.1 - 4.3e-08 32.7 0.0 4.9e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain DUF3885 PF13021.6 ORX72764.1 - 0.059 13.5 0.0 0.093 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) DNA_pol_B PF00136.21 ORX72765.1 - 4.2e-129 431.2 1.1 9.8e-88 294.9 0.0 2.4 2 1 1 3 3 3 2 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX72765.1 - 9.8e-81 271.5 0.0 1.7e-80 270.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ORX72765.1 - 1.8e-17 63.6 6.1 4.2e-17 62.4 6.1 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ORX72765.1 - 0.003 16.5 0.2 0.031 13.1 0.1 2.4 2 1 1 3 3 3 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 ORX72765.1 - 0.0095 15.6 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Nop10p PF04135.12 ORX72767.1 - 5.2e-24 84.0 0.4 6e-24 83.8 0.4 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DUF1674 PF07896.12 ORX72769.1 - 2.2e-07 31.3 7.4 3.6e-06 27.3 7.4 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) PIG-P PF08510.12 ORX72770.1 - 3.1e-09 36.8 13.8 8.4e-06 25.7 11.9 2.9 2 1 0 2 2 2 2 PIG-P Peptidase_S24 PF00717.23 ORX72771.1 - 0.012 15.6 0.1 0.068 13.1 0.1 2.1 1 1 0 1 1 1 0 Peptidase S24-like Pterin_bind PF00809.22 ORX72772.1 - 2.1e-82 276.5 0.1 1.5e-81 273.7 0.1 2.2 1 1 0 1 1 1 1 Pterin binding enzyme FolB PF02152.18 ORX72772.1 - 8.2e-49 164.8 6.0 9.8e-24 84.1 1.2 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 ORX72772.1 - 1.7e-35 121.9 0.4 1.4e-34 118.9 0.0 2.5 2 1 1 3 3 3 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) TrbL PF04610.14 ORX72773.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein FMN_red PF03358.15 ORX72774.1 - 3e-14 53.0 0.0 4.7e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX72774.1 - 1.4e-07 31.5 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX72774.1 - 0.00073 19.8 0.1 0.0032 17.7 0.1 1.9 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX72774.1 - 0.021 15.1 0.0 8.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain ApbA_C PF08546.11 ORX72778.1 - 4.9e-31 107.5 0.0 3.3e-30 104.9 0.0 2.1 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ORX72778.1 - 8e-28 97.0 0.0 1.3e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_8 PF13450.6 ORX72778.1 - 0.0026 18.0 0.2 0.0053 17.0 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX72778.1 - 0.0054 16.0 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ORX72778.1 - 0.014 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ORX72778.1 - 0.018 15.2 0.0 0.034 14.3 0.0 1.6 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ORX72778.1 - 0.018 15.0 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 ORX72778.1 - 0.037 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ORX72778.1 - 0.044 14.3 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 ORX72778.1 - 0.054 12.8 0.1 0.92 8.8 0.1 2.2 2 1 0 2 2 2 0 ThiF family F420_oxidored PF03807.17 ORX72778.1 - 0.059 13.9 0.1 0.21 12.2 0.1 2.0 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 ORX72778.1 - 0.063 13.5 0.0 0.23 11.7 0.0 2.0 3 0 0 3 3 3 0 TrkA-N domain NAD_binding_10 PF13460.6 ORX72778.1 - 0.069 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding DAO PF01266.24 ORX72778.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ORX72778.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Arrestin_N PF00339.29 ORX72779.1 - 7e-07 29.4 0.1 0.0021 18.1 0.1 2.3 1 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX72779.1 - 0.0037 17.0 0.0 0.0067 16.1 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Pkinase PF00069.25 ORX72780.1 - 1.5e-75 254.0 0.0 1.7e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX72780.1 - 3e-31 108.7 0.0 3.9e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX72780.1 - 0.00054 19.0 0.0 0.0084 15.1 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX72780.1 - 0.0028 17.0 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ORX72780.1 - 0.1 12.5 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family UreE_N PF02814.15 ORX72781.1 - 0.0071 15.9 0.0 0.19 11.3 0.0 2.3 2 0 0 2 2 2 2 UreE urease accessory protein, N-terminal domain SmpA_OmlA PF04355.13 ORX72782.1 - 0.03 14.1 0.0 0.042 13.7 0.0 1.2 1 0 0 1 1 1 0 SmpA / OmlA family F-box-like PF12937.7 ORX72783.1 - 0.0069 16.3 0.3 0.017 15.0 0.3 1.6 1 0 0 1 1 1 1 F-box-like DCX PF03607.17 ORX72783.1 - 0.076 13.1 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Doublecortin PliI PF16743.5 ORX72784.1 - 0.011 15.5 0.1 2.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Periplasmic lysozyme inhibitor of I-type lysozyme BBS2_C PF14782.6 ORX72784.1 - 0.025 13.4 0.0 0.39 9.4 0.0 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal VCBS PF13517.6 ORX72784.1 - 0.026 15.1 0.7 0.45 11.2 0.2 2.8 2 1 2 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PTCB-BRCT PF12738.7 ORX72786.1 - 8e-34 115.4 2.9 6.7e-20 70.8 0.1 6.2 6 0 0 6 6 6 3 twin BRCT domain BRCT PF00533.26 ORX72786.1 - 4e-20 72.0 0.0 6.3e-11 42.5 0.0 4.6 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX72786.1 - 6e-11 42.6 0.0 0.11 13.0 0.0 4.6 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ORX72786.1 - 1.3e-09 38.2 0.5 0.082 13.2 0.0 5.6 5 1 1 6 6 6 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 ORX72786.1 - 2.1e-07 30.8 0.0 9.4e-07 28.6 0.0 2.0 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Herpes_LMP1 PF05297.11 ORX72786.1 - 2.4 7.3 4.8 3.6 6.7 4.8 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) NOT2_3_5 PF04153.18 ORX72787.1 - 5.5e-30 104.1 0.5 5.5e-30 104.1 0.5 2.1 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family TFIIA PF03153.13 ORX72787.1 - 1.8 8.5 34.4 2.8 7.8 14.2 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit BRO1 PF03097.18 ORX72788.1 - 1.9e-110 369.3 1.3 1.9e-110 369.3 1.3 1.9 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ORX72788.1 - 6.3e-28 97.9 7.7 6.3e-28 97.9 7.7 2.0 1 1 1 2 2 2 1 ALIX V-shaped domain binding to HIV SseC PF04888.12 ORX72788.1 - 2.9 7.4 7.4 17 4.9 0.4 3.5 3 0 0 3 3 3 0 Secretion system effector C (SseC) like family PGI PF00342.19 ORX72789.1 - 6.4e-241 800.1 0.2 7.3e-241 799.9 0.2 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase MRP-L47 PF06984.13 ORX72790.1 - 5.3e-26 90.6 0.5 8.9e-26 89.8 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 ORX72790.1 - 7.5e-08 32.2 3.2 7.5e-08 32.2 3.2 2.4 2 1 0 2 2 2 1 Ribosomal L29 protein RNA_pol_Rbc25 PF08292.12 ORX72790.1 - 0.024 14.9 0.9 0.034 14.4 0.9 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 VSG_B PF13206.6 ORX72790.1 - 0.11 11.8 5.4 0.12 11.6 5.4 1.0 1 0 0 1 1 1 0 Trypanosomal VSG domain SH3BGR PF04908.15 ORX72790.1 - 0.27 11.4 2.5 1 9.6 0.8 2.1 1 1 1 2 2 2 0 SH3-binding, glutamic acid-rich protein FMN_red PF03358.15 ORX72794.1 - 3e-14 53.0 0.0 4.7e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX72794.1 - 1.3e-07 31.5 0.0 1.7e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX72794.1 - 0.00071 19.8 0.1 0.0032 17.7 0.1 1.9 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX72794.1 - 0.021 15.1 0.0 8.1 6.7 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain TrbL PF04610.14 ORX72795.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein Oxidored_molyb PF00174.19 ORX72796.1 - 6.4e-47 159.4 0.0 1e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ORX72796.1 - 8.3e-40 136.0 0.2 1.3e-39 135.4 0.2 1.2 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Big_7 PF17957.1 ORX72796.1 - 0.00091 20.0 0.0 0.0017 19.1 0.0 1.6 1 1 0 1 1 1 1 Bacterial Ig domain BNR PF02012.20 ORX72796.1 - 0.064 13.3 0.2 0.25 11.5 0.0 2.1 2 0 0 2 2 2 0 BNR/Asp-box repeat Semialdhyde_dhC PF02774.18 ORX72797.1 - 3.4e-39 134.8 0.0 4.7e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 ORX72797.1 - 7.9e-30 103.8 0.0 1.3e-29 103.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 ORX72797.1 - 0.0058 17.3 0.0 0.022 15.5 0.0 2.0 2 0 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sacchrp_dh_NADP PF03435.18 ORX72797.1 - 0.075 13.3 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 ORX72798.1 - 5.3e-58 196.2 0.0 8.2e-58 195.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 ORX72798.1 - 7.6e-09 36.0 0.0 2.9e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 Rhodanese-like domain NAD_binding_7 PF13241.6 ORX72798.1 - 0.019 15.4 0.0 0.071 13.5 0.0 2.0 1 1 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 ORX72798.1 - 0.089 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PglD_N PF17836.1 ORX72798.1 - 0.13 12.9 0.1 0.39 11.4 0.0 1.8 2 0 0 2 2 2 0 PglD N-terminal domain DapB_N PF01113.20 ORX72798.1 - 0.21 11.7 0.3 0.87 9.7 0.1 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DivIC PF04977.15 ORX72798.1 - 1.4 8.8 3.9 1 9.2 1.7 2.0 2 0 0 2 2 2 0 Septum formation initiator zf-CCHC PF00098.23 ORX72799.1 - 0.0022 18.0 2.4 0.0055 16.7 2.4 1.7 1 0 0 1 1 1 1 Zinc knuckle Peptidase_C97 PF05903.14 ORX72802.1 - 0.022 14.6 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 PPPDE putative peptidase domain FKBP_C PF00254.28 ORX72803.1 - 1.5e-35 121.4 0.0 1.7e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Spo7 PF03907.13 ORX72804.1 - 5.7e-07 29.2 6.7 8.8e-07 28.6 0.2 2.4 2 1 0 2 2 2 2 Spo7-like protein DUF908 PF06012.12 ORX72804.1 - 2.1 7.7 10.1 6.5 6.1 10.1 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF5389 PF17364.2 ORX72805.1 - 0.082 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5389) PAP2 PF01569.21 ORX72806.1 - 9.4e-16 57.8 8.0 9.4e-16 57.8 8.0 1.8 2 0 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 ORX72806.1 - 0.043 14.0 2.3 0.13 12.4 0.3 2.4 2 0 0 2 2 2 0 Divergent PAP2 family PAP2_3 PF14378.6 ORX72806.1 - 1.5 8.5 20.3 0.085 12.5 14.4 2.1 2 1 0 2 2 2 0 PAP2 superfamily Fer4_5 PF12801.7 ORX72806.1 - 3 7.9 8.4 0.22 11.5 2.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain DUF4301 PF14134.6 ORX72807.1 - 0.18 10.6 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) AMP-binding PF00501.28 ORX72808.1 - 7.9e-40 136.7 0.0 1.2e-39 136.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ORX72808.1 - 4.5e-10 39.3 0.8 8.9e-10 38.3 0.8 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ORX72808.1 - 0.0015 19.5 0.0 0.0039 18.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CE2_N PF17996.1 ORX72808.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal DIM PF08194.12 ORX72810.1 - 0.09 13.0 0.3 0.22 11.8 0.3 1.7 1 0 0 1 1 1 0 DIM protein ArfGap PF01412.18 ORX72811.1 - 2.4e-34 117.9 0.2 5.5e-34 116.7 0.2 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Prefoldin PF02996.17 ORX72816.1 - 4.8e-33 113.6 0.1 5.6e-33 113.4 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit End3 PF12761.7 ORX72816.1 - 0.097 12.8 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 HECT PF00632.25 ORX72817.1 - 1.2e-64 218.7 0.0 2e-64 218.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EloA-BP1 PF15870.5 ORX72817.1 - 0.058 13.6 4.3 6 7.1 0.1 2.7 2 0 0 2 2 2 0 ElonginA binding-protein 1 Arm PF00514.23 ORX72817.1 - 0.38 10.9 5.0 9.6 6.4 0.0 5.4 6 2 2 8 8 8 0 Armadillo/beta-catenin-like repeat SET PF00856.28 ORX72818.1 - 0.015 15.7 0.0 0.023 15.1 0.0 1.3 1 0 0 1 1 1 0 SET domain tRNA-synt_1 PF00133.22 ORX72819.1 - 4.7e-31 107.7 0.0 2.7e-14 52.4 0.0 3.8 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ORX72819.1 - 1.2e-12 47.3 0.0 3.6e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ORX72819.1 - 6.1e-12 45.8 0.0 1.4e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ORX72819.1 - 0.0027 17.1 0.0 0.0071 15.7 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Glyco_hydro_18 PF00704.28 ORX72820.1 - 9.6e-39 133.9 0.5 4.5e-38 131.7 0.5 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_18 PF00704.28 ORX72821.1 - 9.2e-36 124.1 0.2 1.5e-35 123.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DnaJ_C PF01556.18 ORX72821.1 - 2.4e-33 115.3 0.0 4.1e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX72821.1 - 4.1e-06 26.8 0.3 6.7e-06 26.2 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain Big_6 PF17936.1 ORX72821.1 - 0.085 13.1 0.7 0.17 12.2 0.7 1.5 1 0 0 1 1 1 0 Bacterial Ig domain CBFD_NFYB_HMF PF00808.23 ORX72822.1 - 1.2e-17 63.9 0.1 2e-17 63.2 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 ORX72822.1 - 0.019 15.0 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated Pterin_4a PF01329.19 ORX72823.1 - 1.3e-15 57.3 0.3 1.9e-13 50.4 0.2 2.4 1 1 1 2 2 2 2 Pterin 4 alpha carbinolamine dehydratase Peptidase_M16_C PF05193.21 ORX72824.1 - 6.5e-41 140.4 0.0 1.5e-40 139.2 0.0 1.6 1 1 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX72824.1 - 1.9e-33 115.5 0.0 8.5e-33 113.4 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) YqeY PF09424.10 ORX72825.1 - 1.6e-35 122.2 7.7 1.9e-35 122.0 7.7 1.0 1 0 0 1 1 1 1 Yqey-like protein Amidase PF01425.21 ORX72828.1 - 8e-67 226.1 0.0 5e-66 223.5 0.0 1.9 1 1 0 1 1 1 1 Amidase DUF3071 PF11268.8 ORX72828.1 - 0.092 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Amidase PF01425.21 ORX72829.1 - 1.4e-68 231.9 0.2 1.9e-59 201.8 0.2 2.0 2 0 0 2 2 2 2 Amidase Sigma70_r1_2 PF00140.20 ORX72829.1 - 0.089 12.8 0.2 11 6.2 0.1 2.5 2 0 0 2 2 2 0 Sigma-70 factor, region 1.2 Amidase PF01425.21 ORX72830.1 - 2.6e-65 221.2 0.0 8.8e-65 219.4 0.0 1.7 1 1 0 1 1 1 1 Amidase Amidase PF01425.21 ORX72831.1 - 1.2e-64 219.0 0.0 1.4e-55 189.1 0.0 2.1 2 0 0 2 2 2 2 Amidase Ribonuc_L-PSP PF01042.21 ORX72832.1 - 2.1e-17 63.2 0.0 2.4e-17 63.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP SPX PF03105.19 ORX72833.1 - 1.5 8.6 4.8 2 8.3 4.8 1.1 1 0 0 1 1 1 0 SPX domain YabA PF06156.13 ORX72835.1 - 0.49 11.1 14.9 3 8.5 1.2 2.7 2 1 0 2 2 2 0 Initiation control protein YabA LPD22 PF18834.1 ORX72835.1 - 1 9.6 0.0 1 9.6 0.0 4.0 4 1 1 5 5 5 0 Large polyvalent protein associated domain 22 SGL PF08450.12 ORX72836.1 - 7.5e-33 114.1 1.1 2.5e-32 112.4 0.4 1.8 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ORX72836.1 - 0.017 15.1 2.8 1.3e+02 2.9 0.0 5.0 5 0 0 5 5 5 0 NHL repeat SBBP PF06739.11 ORX72836.1 - 0.072 13.1 7.4 0.79 9.8 0.7 3.6 4 0 0 4 4 4 0 Beta-propeller repeat Arylesterase PF01731.20 ORX72836.1 - 0.091 13.0 0.0 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 Arylesterase SGL PF08450.12 ORX72837.1 - 1.4e-32 113.3 0.4 6.3e-31 107.8 0.1 2.3 1 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ORX72837.1 - 0.0085 16.1 4.3 59 4.0 0.1 5.4 5 0 0 5 5 5 1 NHL repeat Arylesterase PF01731.20 ORX72837.1 - 0.017 15.3 0.0 0.24 11.6 0.0 2.4 2 0 0 2 2 2 0 Arylesterase Cut8 PF08559.10 ORX72838.1 - 1.6e-25 90.2 0.0 4.4e-25 88.7 0.0 1.6 1 1 0 1 1 1 1 Cut8, nuclear proteasome tether protein Phage_GPA PF05840.13 ORX72838.1 - 0.017 14.2 0.1 0.022 13.9 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) MFS_MOT1 PF16983.5 ORX72839.1 - 4.7e-55 184.7 30.9 1.7e-30 105.7 6.9 3.0 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 ORX72839.1 - 9.2e-07 27.9 12.2 0.00013 20.9 0.2 3.3 2 1 0 2 2 2 2 Sulfate permease family DUF2569 PF10754.9 ORX72839.1 - 0.0066 16.9 1.9 0.0078 16.7 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2569) DUF4131 PF13567.6 ORX72839.1 - 9.4 5.9 9.7 0.71 9.5 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) F-box-like PF12937.7 ORX72840.1 - 0.014 15.3 0.2 0.048 13.6 0.0 2.1 2 0 0 2 2 2 0 F-box-like Deltaretro_Tax PF05599.11 ORX72841.1 - 0.15 12.6 0.1 1.6 9.3 0.0 2.5 2 1 0 2 2 2 0 Deltaretrovirus Tax protein Herpes_capsid PF06112.11 ORX72841.1 - 3.2 7.8 12.4 5 7.2 12.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Asp PF00026.23 ORX72842.1 - 1.2e-57 195.7 0.0 1.4e-57 195.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX72842.1 - 2.9e-12 47.2 0.3 1.2e-09 38.7 0.3 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX72842.1 - 0.038 13.8 0.0 0.083 12.7 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal DUF3443 PF11925.8 ORX72842.1 - 0.1 11.4 0.0 0.51 9.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) Glyco_hydro_18 PF00704.28 ORX72843.1 - 2.8e-22 79.8 6.1 1e-21 78.0 6.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX72843.1 - 1.1e-08 34.9 15.4 1.1e-08 34.9 15.4 4.4 2 1 1 3 3 3 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.24 ORX72843.1 - 0.16 12.1 7.4 0.14 12.4 5.3 2.1 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain Mucin PF01456.17 ORX72843.1 - 0.27 11.2 39.5 0.5 10.3 39.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Med3 PF11593.8 ORX72843.1 - 2.2 7.4 21.7 3.8 6.6 21.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MGC-24 PF05283.11 ORX72843.1 - 4.4 7.8 18.0 15 6.0 18.0 1.9 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Jun PF03957.13 ORX72843.1 - 4.9 7.0 16.5 1.3 8.9 12.2 2.0 2 0 0 2 2 2 0 Jun-like transcription factor DUF3123 PF11321.8 ORX72844.1 - 6.9 7.4 7.3 17 6.1 7.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) ORC6 PF05460.13 ORX72844.1 - 8.7 5.5 7.7 12 5.0 7.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) GIT_CC PF16559.5 ORX72846.1 - 0.068 13.1 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor SIR2 PF02146.17 ORX72847.1 - 1.1e-26 93.9 0.0 2.4e-26 92.7 0.0 1.6 1 1 0 1 1 1 1 Sir2 family PAS_2 PF08446.11 ORX72848.1 - 0.0086 16.7 0.0 0.02 15.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ORX72848.1 - 0.11 12.7 0.0 0.9 9.8 0.0 2.1 2 0 0 2 2 2 0 PAS domain Questin_oxidase PF14027.6 ORX72849.1 - 3.3e-76 257.0 0.3 3.9e-76 256.8 0.3 1.1 1 0 0 1 1 1 1 Questin oxidase-like Transferase PF02458.15 ORX72850.1 - 2.9e-17 62.5 0.0 6e-17 61.4 0.0 1.4 1 1 0 1 1 1 1 Transferase family Transferase PF02458.15 ORX72851.1 - 5.6e-09 35.2 0.0 2e-07 30.1 0.0 2.4 1 1 1 2 2 2 2 Transferase family Lipase_GDSL_2 PF13472.6 ORX72852.1 - 0.032 14.6 0.0 0.062 13.7 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family ERG4_ERG24 PF01222.17 ORX72853.1 - 9.8e-70 235.5 12.9 9.5e-68 228.9 12.9 3.0 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family p450 PF00067.22 ORX72854.1 - 4.3e-60 203.8 0.0 1.9e-59 201.6 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 PP2C PF00481.21 ORX72856.1 - 1.3e-40 139.6 0.0 1.2e-38 133.2 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ORX72856.1 - 0.018 15.0 0.1 0.045 13.7 0.1 1.7 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) SWIB PF02201.18 ORX72857.1 - 9.8e-16 57.4 0.8 2.1e-15 56.4 0.0 2.1 2 0 0 2 2 2 1 SWIB/MDM2 domain SUIM_assoc PF16619.5 ORX72857.1 - 0.31 11.2 9.5 0.84 9.7 9.5 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PhoLip_ATPase_C PF16212.5 ORX72859.1 - 7.9e-60 202.7 29.6 7.9e-60 202.7 29.6 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX72859.1 - 2.2e-20 72.1 1.0 5.4e-20 70.8 1.0 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX72859.1 - 8.3e-11 41.8 0.0 6e-10 39.1 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX72859.1 - 2.3e-08 34.6 0.7 0.00042 20.7 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX72859.1 - 0.00011 22.0 0.5 0.00082 19.2 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sec7 PF01369.20 ORX72861.1 - 0.0025 17.5 0.1 0.0037 17.0 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PNP_UDP_1 PF01048.20 ORX72863.1 - 3.4e-36 124.7 0.5 4e-36 124.4 0.5 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily LPMO_10 PF03067.15 ORX72865.1 - 6.1e-06 27.0 0.1 9.9e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading zf-LITAF-like PF10601.9 ORX72866.1 - 3.5e-14 52.8 0.1 4.7e-14 52.4 0.1 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-LITAF-like PF10601.9 ORX72867.1 - 0.00039 20.6 0.2 0.0007 19.8 0.2 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Sec23_helical PF04815.15 ORX72868.1 - 0.037 13.8 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Pex2_Pex12 PF04757.14 ORX72869.1 - 2e-29 102.8 0.3 1.4e-26 93.5 0.0 2.5 2 1 0 2 2 2 2 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 ORX72869.1 - 5.1e-05 23.0 0.8 8.5e-05 22.3 0.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX72869.1 - 0.00027 20.7 2.3 0.00054 19.7 2.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX72869.1 - 0.0072 16.2 1.2 0.013 15.3 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX72869.1 - 0.0088 16.0 4.5 0.018 15.0 4.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX72869.1 - 0.014 15.7 1.5 0.032 14.5 1.5 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.6 ORX72869.1 - 0.063 13.5 4.6 0.12 12.5 4.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ORX72869.1 - 0.14 12.1 1.8 0.51 10.2 1.8 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 WD40 PF00400.32 ORX72870.1 - 2e-09 37.9 0.4 0.0025 18.6 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72870.1 - 6e-07 29.7 0.1 0.07 13.4 0.0 3.7 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 ORX72870.1 - 0.0018 17.5 0.3 0.0027 16.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 ORX72870.1 - 0.0023 17.0 3.2 0.29 10.1 0.0 2.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CPSF_A PF03178.15 ORX72870.1 - 0.0067 15.8 0.1 0.015 14.6 0.0 1.6 2 0 0 2 2 2 1 CPSF A subunit region Nbas_N PF15492.6 ORX72870.1 - 0.013 14.8 0.1 0.055 12.8 0.1 1.8 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ORX72870.1 - 0.014 15.3 0.0 0.14 12.1 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DicB PF05358.11 ORX72870.1 - 0.06 13.5 0.0 0.18 12.0 0.0 1.7 2 0 0 2 2 2 0 DicB protein BTG PF07742.12 ORX72870.1 - 0.085 12.7 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 BTG family Clathrin_propel PF01394.20 ORX72870.1 - 0.12 12.7 0.0 32 5.1 0.0 2.7 2 0 0 2 2 2 0 Clathrin propeller repeat HECT_2 PF09814.9 ORX72871.1 - 2e-20 73.0 0.4 2.3e-20 72.8 0.4 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding ORC3_N PF07034.11 ORX72872.1 - 3.6e-17 62.5 0.0 4.8e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 ORX72873.1 - 7.9e-34 116.7 1.7 1.2e-31 109.6 1.7 2.2 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal RPA43_OB PF17875.1 ORX72874.1 - 4e-20 72.7 1.1 2.7e-19 70.0 0.0 2.2 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I CFIA_Pcf11 PF11526.8 ORX72874.1 - 0.026 15.0 6.5 0.049 14.1 0.9 2.1 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 CPSF100_C PF13299.6 ORX72874.1 - 0.33 11.1 1.8 5.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Ribosomal_S8e PF01201.22 ORX72875.1 - 2.1e-55 186.6 2.8 2.5e-55 186.4 2.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Metallophos PF00149.28 ORX72876.1 - 3.8e-07 30.8 2.4 5.2e-07 30.4 2.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ydc2-catalyt PF09159.10 ORX72877.1 - 7e-26 91.6 1.6 5.5e-21 75.5 0.2 3.2 1 1 1 2 2 2 2 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pkinase PF00069.25 ORX72878.1 - 1.1e-26 93.8 0.0 1e-15 57.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX72878.1 - 5.7e-08 32.4 0.1 0.00061 19.2 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase FR47 PF08445.10 ORX72878.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein SPX PF03105.19 ORX72878.1 - 0.81 9.5 7.6 1.3 8.9 7.6 1.2 1 0 0 1 1 1 0 SPX domain zf-CCCH PF00642.24 ORX72879.1 - 6.3e-14 51.5 5.7 2e-07 30.7 0.7 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ORX72879.1 - 4.8e-11 42.2 5.6 6.1e-06 25.9 0.3 2.2 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX72879.1 - 1.3e-08 34.6 7.9 0.00043 20.3 0.8 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 ORX72879.1 - 0.0033 17.8 4.3 0.27 11.8 0.3 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX72879.1 - 0.0081 16.8 7.1 0.47 11.2 0.5 2.0 1 1 1 2 2 2 2 Torus domain Tachystatin_B PF11478.8 ORX72879.1 - 0.021 14.8 3.0 0.63 10.0 0.1 2.1 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B zf-CCHH PF10283.9 ORX72879.1 - 0.87 9.6 8.3 1.6 8.8 0.2 2.6 3 0 0 3 3 3 0 PBZ domain zf-CCCH PF00642.24 ORX72880.1 - 1.6e-08 34.3 6.9 2.9e-05 23.8 0.4 2.6 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX72880.1 - 0.0002 21.3 8.0 0.026 14.6 0.7 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ORX72880.1 - 0.0092 15.8 4.1 0.11 12.3 4.1 2.4 1 1 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX72880.1 - 0.52 10.9 3.1 2.8 8.6 3.1 2.3 1 1 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RSN1_7TM PF02714.15 ORX72882.1 - 1.1e-52 179.1 16.3 1.1e-52 179.1 16.3 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX72882.1 - 3.5e-17 62.6 0.1 3.5e-17 62.6 0.1 2.7 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX72882.1 - 2e-13 51.0 0.0 3.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter TMEM220 PF15071.6 ORX72882.1 - 1.6 9.6 6.6 0.82 10.5 0.3 3.2 4 0 0 4 4 4 0 Transmembrane family 220, helix Lactamase_B_2 PF12706.7 ORX72883.1 - 5.9e-29 101.0 0.0 7.5e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX72883.1 - 5.6e-07 29.8 0.3 1.3e-06 28.6 0.1 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ORX72883.1 - 0.009 15.5 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain EF-hand_1 PF00036.32 ORX72885.1 - 1.9e-22 77.1 7.7 6.8e-07 28.4 0.0 5.6 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 ORX72885.1 - 2.9e-20 70.4 5.2 1e-06 28.2 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 ORX72885.1 - 1.2e-19 70.5 3.4 3e-07 30.8 0.0 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ORX72885.1 - 7.7e-16 56.8 3.3 0.00045 19.6 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ORX72885.1 - 4.2e-15 55.3 5.9 2.8e-08 33.5 0.1 4.9 4 1 1 5 5 5 3 EF-hand domain pair DUF3368 PF11848.8 ORX72885.1 - 0.0047 16.7 0.0 0.008 15.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3368) Caleosin PF05042.13 ORX72885.1 - 0.18 11.7 2.2 2.2 8.2 0.2 2.7 1 1 1 2 2 2 0 Caleosin related protein DNA_primase_lrg PF04104.14 ORX72886.1 - 1.3e-75 254.3 0.0 2e-75 253.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit SRP68 PF16969.5 ORX72887.1 - 9e-30 104.2 14.3 5.6e-17 62.0 7.6 3.0 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 Flu_M1_C PF08289.11 ORX72887.1 - 0.41 10.9 0.1 0.41 10.9 0.1 2.2 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain APH PF01636.23 ORX72888.1 - 1.7e-10 41.2 0.0 1.9e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX72888.1 - 1.8e-06 27.7 0.0 2e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 ORX72888.1 - 0.059 12.7 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 ORX72888.1 - 0.06 12.7 0.0 0.062 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Kdo PF06293.14 ORX72888.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX72888.1 - 0.14 11.7 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 ORX72888.1 - 0.18 10.8 0.0 0.2 10.6 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain IlvB_leader PF08049.11 ORX72889.1 - 0.37 10.7 5.3 0.92 9.5 5.3 1.7 1 0 0 1 1 1 0 IlvB leader peptide SDA1 PF05285.12 ORX72890.1 - 7.9e-66 222.9 49.1 1e-65 222.5 39.9 3.0 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 ORX72890.1 - 2.4e-20 72.6 0.3 6.3e-20 71.2 0.3 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Chromosome_seg PF13889.6 ORX72892.1 - 0.069 13.3 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Chromosome segregation during meiosis WD40 PF00400.32 ORX72893.1 - 9e-22 77.0 19.9 1.1e-05 26.1 0.2 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX72893.1 - 8.1e-21 74.1 7.4 9.8e-08 32.2 0.3 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX72893.1 - 2.8e-10 40.4 1.3 5.7e-05 23.1 0.3 3.3 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX72893.1 - 3.2e-08 32.9 0.0 0.00022 20.3 0.0 3.2 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ORX72893.1 - 0.00027 19.1 4.5 0.089 10.8 0.4 2.6 3 0 0 3 3 3 2 IKI3 family DUF1513 PF07433.11 ORX72893.1 - 0.00038 19.6 1.5 0.035 13.2 0.2 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1513) PD40 PF07676.12 ORX72893.1 - 0.0015 18.5 0.2 3.7 7.6 0.0 3.5 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ORX72893.1 - 0.0024 17.3 1.0 0.24 10.7 1.0 2.4 1 1 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal DUF2833 PF11090.8 ORX72893.1 - 0.12 12.8 1.8 82 3.7 0.0 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF2833) TFIID-31kDa PF02291.15 ORX72894.1 - 1.5e-48 163.8 0.0 1.9e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX72894.1 - 2.1e-07 30.8 0.0 3.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 ORX72894.1 - 1.1e-06 29.1 0.9 1.2e-06 28.9 0.0 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX72894.1 - 9e-06 26.0 0.1 1.5e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX72894.1 - 0.0012 18.9 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_30kDa PF03540.13 ORX72894.1 - 0.0069 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit TFIID_20kDa PF03847.13 ORX72894.1 - 0.016 15.7 0.9 0.017 15.6 0.1 1.4 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A TIP49_C PF17856.1 ORX72894.1 - 0.024 14.8 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 AAA-lid domain Ribosomal_S11 PF00411.19 ORX72895.1 - 1.5e-45 154.1 1.6 1.9e-45 153.8 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Mito_carr PF00153.27 ORX72896.1 - 8.4e-57 189.1 1.3 2.5e-21 75.4 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF5551 PF17705.1 ORX72897.1 - 0.16 11.6 0.0 0.42 10.2 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5551) BssB_TutG PF18512.1 ORX72900.1 - 0.9 9.5 4.3 2.1 8.3 4.3 1.5 1 0 0 1 1 1 0 Benzylsuccinate synthase beta subunit SSP160 PF06933.11 ORX72900.1 - 2.7 6.1 14.0 0.016 13.4 5.4 1.6 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 EMC3_TMCO1 PF01956.16 ORX72901.1 - 5.8e-49 166.1 1.7 7.5e-49 165.7 1.7 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Phosducin PF02114.16 ORX72902.1 - 3.2e-18 65.6 0.1 3.8e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ORX72902.1 - 0.0036 17.2 0.1 0.0083 16.1 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin SIMPL PF04402.14 ORX72902.1 - 0.088 13.3 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) DJ-1_PfpI PF01965.24 ORX72903.1 - 8e-42 142.8 0.2 9.3e-42 142.6 0.2 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 ORX72903.1 - 3e-06 27.0 0.3 5.7e-06 26.0 0.3 1.5 1 1 0 1 1 1 1 C-terminal domain found in long catalases ThiJ_like PF17124.5 ORX72903.1 - 4.1e-06 26.6 0.0 1e-05 25.3 0.0 1.6 1 1 0 2 2 2 1 ThiJ/PfpI family-like GATase_3 PF07685.14 ORX72903.1 - 0.0049 16.5 0.0 0.0058 16.3 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ORX72903.1 - 0.025 14.4 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family SOGA PF11365.8 ORX72905.1 - 0.00025 22.1 11.8 0.0011 20.0 4.1 2.7 2 1 0 2 2 2 1 Protein SOGA OmpH PF03938.14 ORX72905.1 - 0.033 14.5 19.1 1.1 9.6 7.8 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ORX72905.1 - 0.089 12.2 17.6 0.11 12.0 17.6 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 ORX72905.1 - 0.098 12.7 23.6 0.12 12.4 16.4 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HIP1_clath_bdg PF16515.5 ORX72905.1 - 0.21 12.2 19.9 0.69 10.5 2.7 3.1 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Prominin PF05478.11 ORX72905.1 - 0.22 9.5 11.2 0.25 9.3 11.2 1.0 1 0 0 1 1 1 0 Prominin DUF1461 PF07314.11 ORX72905.1 - 0.23 11.3 0.5 0.35 10.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) bZIP_1 PF00170.21 ORX72905.1 - 0.61 10.2 13.1 0.18 11.9 2.1 3.7 2 2 2 4 4 4 0 bZIP transcription factor DUF2951 PF11166.8 ORX72905.1 - 0.63 10.3 4.7 5.4 7.3 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) HAUS-augmin3 PF14932.6 ORX72905.1 - 0.69 9.4 16.8 2.3 7.7 16.3 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.8 ORX72905.1 - 1.1 9.3 18.0 3 7.9 4.4 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 ORX72905.1 - 1.1 9.4 18.2 1.5 9.1 7.9 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 PRKG1_interact PF15898.5 ORX72905.1 - 1.3 10.0 20.8 1 10.3 7.5 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Exonuc_VII_L PF02601.15 ORX72905.1 - 1.4 8.4 9.0 2.1 7.8 9.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.6 ORX72905.1 - 1.5 9.3 15.0 0.034 14.6 6.0 2.0 1 1 1 2 2 2 0 Snapin/Pallidin ZapB PF06005.12 ORX72905.1 - 1.6 9.2 19.4 1 9.9 3.2 3.1 1 1 2 3 3 3 0 Cell division protein ZapB TSC22 PF01166.18 ORX72905.1 - 1.6 9.1 7.1 2.4 8.6 0.2 3.4 2 1 1 3 3 3 0 TSC-22/dip/bun family GIT_CC PF16559.5 ORX72905.1 - 1.7 8.6 13.2 0.25 11.2 3.1 3.3 2 1 2 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 ORX72905.1 - 1.8 9.3 13.4 6.4 7.5 8.4 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Lectin_N PF03954.14 ORX72905.1 - 2.5 7.9 10.3 39 4.0 10.3 2.1 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF4407 PF14362.6 ORX72905.1 - 3.3 7.0 13.9 4.9 6.4 13.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sipho_Gp157 PF05565.11 ORX72905.1 - 4.2 7.3 13.6 32 4.5 12.8 2.4 1 1 1 2 2 2 0 Siphovirus Gp157 V_ATPase_I PF01496.19 ORX72905.1 - 6.2 4.6 8.4 6.8 4.5 8.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tup_N PF08581.10 ORX72905.1 - 6.9 7.0 14.7 1.3 9.3 3.2 3.0 1 1 1 2 2 2 0 Tup N-terminal CCDC-167 PF15188.6 ORX72905.1 - 7.8 6.9 15.9 3 8.2 8.9 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 ORX72905.1 - 8.6 6.4 9.9 6.8 6.8 1.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Tmemb_cc2 PF10267.9 ORX72906.1 - 0.0023 17.2 0.7 0.0029 16.8 0.7 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Golgin_A5 PF09787.9 ORX72906.1 - 0.022 14.2 5.6 0.029 13.8 5.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 UPF0242 PF06785.11 ORX72906.1 - 0.042 14.0 3.2 0.059 13.5 3.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CCDC-167 PF15188.6 ORX72906.1 - 0.056 13.8 6.1 0.13 12.6 6.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 AKNA PF12443.8 ORX72906.1 - 0.08 13.6 1.6 0.74 10.5 0.8 2.4 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF2205 PF10224.9 ORX72906.1 - 0.13 12.3 3.0 0.39 10.7 3.0 1.9 1 0 0 1 1 1 0 Short coiled-coil protein DUF4407 PF14362.6 ORX72906.1 - 0.17 11.2 3.1 0.26 10.6 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PRKG1_interact PF15898.5 ORX72906.1 - 0.3 12.0 7.3 0.6 11.0 7.3 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain TMF_DNA_bd PF12329.8 ORX72906.1 - 0.92 9.6 6.7 0.97 9.5 0.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4337 PF14235.6 ORX72906.1 - 1.7 8.8 5.9 3 7.9 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) APG6_N PF17675.1 ORX72906.1 - 2.9 8.4 14.4 2.2 8.8 11.9 2.1 2 1 0 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 ORX72906.1 - 5.3 7.6 8.7 3.8 8.0 2.6 2.5 1 1 1 2 2 2 0 Cell division protein ZapB ATP-synt_I PF03899.15 ORX72907.1 - 0.063 13.7 0.5 0.094 13.1 0.5 1.2 1 0 0 1 1 1 0 ATP synthase I chain E1_dh PF00676.20 ORX72908.1 - 4e-29 101.5 0.0 3e-27 95.4 0.0 3.0 2 1 0 2 2 2 1 Dehydrogenase E1 component Transket_pyr PF02779.24 ORX72908.1 - 3.9e-27 95.1 0.0 7.2e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain UQ_con PF00179.26 ORX72909.1 - 1.6e-39 134.7 0.0 2e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX72909.1 - 0.042 14.1 0.0 0.054 13.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain NIR_SIR PF01077.22 ORX72910.1 - 4.3e-53 179.1 0.0 8.5e-47 158.6 0.0 2.3 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 ORX72910.1 - 7e-28 96.3 0.0 3.2e-15 55.7 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 ORX72910.1 - 3.2e-21 76.0 0.1 1.5e-20 73.8 0.0 2.2 2 0 0 2 2 2 1 Flavodoxin POR_N PF01855.19 ORX72910.1 - 2e-07 31.0 0.2 5.8e-07 29.5 0.2 1.7 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Pex26 PF07163.12 ORX72910.1 - 0.12 11.6 0.1 0.22 10.8 0.1 1.3 1 0 0 1 1 1 0 Pex26 protein CoA_binding_2 PF13380.6 ORX72910.1 - 0.96 10.0 3.5 7.5 7.1 2.0 2.8 2 1 1 3 3 3 0 CoA binding domain PAPS_reduct PF01507.19 ORX72911.1 - 4.9e-44 150.4 0.1 1.1e-43 149.3 0.0 1.6 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family ATG101 PF07855.12 ORX72911.1 - 5.8e-38 130.3 2.7 8.7e-38 129.7 2.7 1.3 1 0 0 1 1 1 1 Autophagy-related protein 101 DUF3347 PF11827.8 ORX72911.1 - 0.17 12.1 0.5 0.34 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) DUF713 PF05218.14 ORX72911.1 - 0.26 11.0 2.9 0.3 10.8 1.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF713) SAC3 PF12209.8 ORX72913.1 - 0.0018 18.4 0.8 0.0086 16.2 0.2 2.2 2 1 0 2 2 2 1 Leucine permease transcriptional regulator helical domain Sgf11_N PF18519.1 ORX72913.1 - 0.016 14.7 0.0 0.054 13.1 0.0 1.8 1 0 0 1 1 1 0 SAGA-associated factor 11 N-terminal domain CID_GANP PF16766.5 ORX72913.1 - 0.061 13.5 1.0 0.21 11.8 0.2 2.2 1 1 2 3 3 3 0 Binding region of GANP to ENY2 SAC3_GANP PF03399.16 ORX72914.1 - 2.9e-49 168.0 0.7 3.3e-49 167.8 0.7 1.0 1 0 0 1 1 1 1 SAC3/GANP family Nup188_C PF18378.1 ORX72914.1 - 0.029 13.2 0.1 0.035 12.9 0.1 1.1 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain F-box-like PF12937.7 ORX72916.1 - 2.3e-07 30.6 0.6 1.1e-06 28.4 0.3 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX72916.1 - 0.00016 21.4 0.5 0.0035 17.2 0.5 2.7 1 1 0 1 1 1 1 F-box domain Arm PF00514.23 ORX72917.1 - 1.2e-92 301.5 15.2 3.4e-13 49.1 0.2 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 ORX72917.1 - 3.2e-24 85.2 2.1 7.3e-24 84.0 2.1 1.7 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 ORX72917.1 - 1.5e-22 78.8 5.0 3.9e-22 77.6 4.2 2.1 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 ORX72917.1 - 2.8e-18 66.0 3.5 1.1e-07 32.2 0.1 6.2 5 3 3 8 8 8 3 HEAT-like repeat HEAT_2 PF13646.6 ORX72917.1 - 8.5e-17 61.3 1.0 2.6e-06 27.7 0.0 5.8 3 2 4 7 7 7 4 HEAT repeats HEAT PF02985.22 ORX72917.1 - 5.3e-16 57.3 0.6 6.3e-05 22.9 0.0 6.5 8 0 0 8 8 7 3 HEAT repeat Arm_2 PF04826.13 ORX72917.1 - 1.1e-06 28.3 0.7 0.047 13.1 0.0 3.6 1 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 ORX72917.1 - 1.1e-05 25.5 0.3 1 9.5 0.0 4.0 3 2 1 4 4 4 1 V-ATPase subunit H Adaptin_N PF01602.20 ORX72917.1 - 2.1e-05 23.3 0.0 0.00018 20.2 0.0 2.3 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_PBS PF03130.16 ORX72917.1 - 0.00011 22.5 1.2 0.037 14.7 0.0 4.6 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 ORX72917.1 - 0.00021 20.9 0.0 12 5.5 0.0 4.9 2 2 3 5 5 5 0 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 ORX72917.1 - 0.00045 20.4 0.6 0.63 10.3 0.0 4.1 2 2 2 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_N PF03224.14 ORX72917.1 - 0.00068 19.0 0.0 0.38 10.0 0.0 2.5 1 1 0 2 2 2 2 V-ATPase subunit H CTNNBL PF08216.11 ORX72917.1 - 0.0028 17.8 0.9 3.7 7.8 0.0 4.4 4 1 0 4 4 4 1 Catenin-beta-like, Arm-motif containing nuclear ParcG PF10274.9 ORX72917.1 - 0.071 13.2 0.1 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Parkin co-regulated protein CDC24 PF06395.11 ORX72917.1 - 0.11 12.8 0.0 16 5.8 0.0 3.4 3 0 0 3 3 3 0 CDC24 Calponin Pescadillo_N PF06732.11 ORX72918.1 - 1.4e-119 398.6 0.5 1.4e-119 398.6 0.5 1.8 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 ORX72918.1 - 2.4e-07 31.1 0.0 7.9e-07 29.4 0.0 2.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Astro_capsid_p PF12226.8 ORX72918.1 - 0.014 14.6 4.1 0.035 13.3 4.1 1.6 1 0 0 1 1 1 0 Turkey astrovirus capsid protein WD40 PF00400.32 ORX72920.1 - 1.2e-23 82.9 8.3 3.4e-06 27.7 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat Bromodomain PF00439.25 ORX72920.1 - 4e-12 46.0 0.0 7.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Bromodomain ANAPC4_WD40 PF12894.7 ORX72920.1 - 1.3e-10 41.5 0.2 0.54 10.6 0.0 5.7 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain ORC6 PF05460.13 ORX72920.1 - 0.00028 20.3 1.8 0.00028 20.3 1.8 3.3 2 1 2 4 4 4 1 Origin recognition complex subunit 6 (ORC6) PQQ_2 PF13360.6 ORX72920.1 - 0.0011 18.6 0.5 0.0093 15.6 0.0 2.4 2 1 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.5 ORX72920.1 - 0.0063 15.5 0.7 13 4.6 0.0 3.6 2 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Auxin_resp PF06507.13 ORX72920.1 - 0.049 13.9 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Auxin response factor PALB2_WD40 PF16756.5 ORX72920.1 - 0.053 12.4 0.0 2 7.3 0.0 2.4 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Pkinase PF00069.25 ORX72921.1 - 1e-54 185.7 0.1 4.2e-54 183.7 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX72921.1 - 3.7e-35 121.5 0.2 8.2e-34 117.0 0.2 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX72921.1 - 2.3e-19 69.5 0.9 9.8e-19 67.5 0.0 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 ORX72921.1 - 1.3e-05 24.7 0.2 0.00012 21.5 0.2 2.2 1 1 0 1 1 1 1 Kinase-like DSHCT PF08148.12 ORX72921.1 - 0.00088 19.0 1.0 0.0016 18.2 0.0 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain APH PF01636.23 ORX72921.1 - 0.022 14.7 0.2 0.85 9.5 0.1 2.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX72921.1 - 0.032 13.6 0.6 0.51 9.7 0.0 2.3 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX72921.1 - 0.35 10.5 4.3 0.91 9.1 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PTR2 PF00854.21 ORX72922.1 - 2e-80 270.6 4.4 6.3e-80 268.9 4.4 1.8 1 1 0 1 1 1 1 POT family ADIP PF11559.8 ORX72923.1 - 2.9e-08 33.9 12.5 5.2e-05 23.4 2.0 4.0 2 2 2 4 4 4 2 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 ORX72923.1 - 0.011 14.6 8.7 0.14 11.0 0.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 ORX72923.1 - 1.1 9.8 10.8 9.2 6.8 0.3 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region GAS PF13851.6 ORX72923.1 - 2.4 7.5 9.9 1.1 8.5 5.3 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding IFP_35_N PF07334.13 ORX72923.1 - 8.7 6.5 9.0 9.6 6.4 0.1 3.5 3 1 1 4 4 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus VHS PF00790.19 ORX72924.1 - 6.5e-35 120.0 0.8 1.7e-34 118.7 0.8 1.7 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 ORX72924.1 - 1.7e-09 37.8 0.6 1.7e-09 37.8 0.6 2.3 2 0 0 2 2 2 1 GAT domain SH3_1 PF00018.28 ORX72924.1 - 1.2e-05 24.8 0.0 2.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX72924.1 - 7.2e-05 22.4 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX72924.1 - 0.00037 20.3 0.0 0.00085 19.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 ORX72924.1 - 0.0019 18.0 2.6 0.0059 16.4 2.6 2.0 1 0 0 1 1 1 1 Ubiquitin interaction motif DUF3361 PF11841.8 ORX72924.1 - 0.065 13.2 0.5 0.22 11.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) ANTH PF07651.16 ORX72924.1 - 0.071 12.1 0.2 0.071 12.1 0.2 2.4 3 0 0 3 3 3 0 ANTH domain PEPCK_ATP PF01293.20 ORX72926.1 - 2.4e-228 758.4 0.0 2.7e-228 758.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Bestrophin PF01062.21 ORX72928.1 - 0.22 10.9 4.9 0.21 10.9 4.9 1.0 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Pkinase PF00069.25 ORX72929.1 - 9.1e-08 31.8 0.0 1.4e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.11 ORX72929.1 - 6.5e-06 25.9 0.0 9.6e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 ORX72929.1 - 6.6e-06 25.9 0.0 2.8e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 ORX72929.1 - 0.0001 22.3 0.1 0.00012 22.0 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ORX72929.1 - 0.0019 17.5 0.0 0.0086 15.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ORX72929.1 - 0.0041 16.7 0.0 0.72 9.4 0.0 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase Kdo PF06293.14 ORX72929.1 - 0.0065 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX72929.1 - 0.0079 15.0 0.1 0.038 12.8 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ORX72929.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 ORX72929.1 - 0.038 13.6 0.1 0.074 12.7 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PEPCK_ATP PF01293.20 ORX72930.1 - 6.1e-228 757.1 0.0 7e-228 756.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase FtsJ PF01728.19 ORX72931.1 - 6.3e-26 91.6 0.0 6.9e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase AA_permease PF00324.21 ORX72932.1 - 6.7e-66 222.8 34.7 8.3e-42 143.4 11.2 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 ORX72932.1 - 9.6e-09 34.8 0.4 0.04 12.9 0.1 3.2 3 0 0 3 3 3 3 Solute carrier family 12 RhoGAP PF00620.27 ORX72933.1 - 1.7e-27 96.1 0.0 3.3e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain zf-C2H2 PF00096.26 ORX72934.1 - 7.7e-12 45.0 8.5 1.4e-05 25.3 0.7 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX72934.1 - 4.5e-11 42.6 10.2 5.6e-07 29.7 0.8 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX72934.1 - 9.9e-09 35.3 7.3 0.00056 20.5 1.4 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX72934.1 - 1.9e-05 24.8 0.5 0.0008 19.6 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX72934.1 - 2.8e-05 24.3 2.8 6.7e-05 23.1 0.5 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 ORX72934.1 - 0.0065 16.7 0.9 0.013 15.8 0.8 1.5 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX72934.1 - 0.018 15.0 9.6 0.78 9.8 2.1 2.6 2 2 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 ORX72934.1 - 0.054 13.6 1.0 2.4 8.3 0.1 2.3 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 ORX72934.1 - 0.081 13.3 3.7 0.17 12.2 2.0 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 ORX72934.1 - 0.11 12.2 1.8 0.12 12.0 1.4 1.4 1 1 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C3HC4_2 PF13923.6 ORX72934.1 - 0.13 12.1 2.3 0.25 11.2 2.3 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2_11 PF16622.5 ORX72934.1 - 0.29 10.9 0.4 0.29 10.9 0.4 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type Peptidase_S9 PF00326.21 ORX72935.1 - 1e-39 136.2 0.0 1.5e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ORX72935.1 - 1.2e-06 28.6 0.0 3.2e-06 27.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ORX72935.1 - 3.9e-06 26.7 0.0 0.01 15.5 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 ORX72935.1 - 4.2e-06 26.5 0.2 2.5e-05 23.9 0.2 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ORX72935.1 - 4.1e-05 23.0 0.1 0.16 11.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ORX72935.1 - 0.002 17.8 0.0 1.4 8.4 0.0 2.3 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Esterase_phd PF10503.9 ORX72935.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase FSH1 PF03959.13 ORX72935.1 - 0.017 14.8 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) BAAT_C PF08840.11 ORX72935.1 - 0.023 14.6 0.0 1.1 9.1 0.0 2.2 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 ORX72935.1 - 0.053 12.2 0.0 0.089 11.4 0.0 1.5 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) 2-oxoacid_dh PF00198.23 ORX72936.1 - 1.2e-80 270.4 0.1 1.5e-80 270.0 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 ORX72936.1 - 8.4e-18 64.4 0.2 3e-17 62.7 0.2 2.1 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 ORX72936.1 - 3.6e-17 61.9 0.1 7.2e-17 61.0 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ORX72936.1 - 0.018 14.8 0.5 0.044 13.6 0.0 1.9 2 0 0 2 2 2 0 Biotin-lipoyl like DUF3597 PF12200.8 ORX72936.1 - 3.2 8.3 13.8 3.5 8.2 2.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Glycos_transf_2 PF00535.26 ORX72937.1 - 1.2e-24 87.1 0.0 1.5e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ORX72937.1 - 2.1e-09 37.6 0.0 6.2e-09 36.1 0.0 1.6 1 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ORX72937.1 - 0.0003 20.3 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ORX72937.1 - 0.018 15.6 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 SpoU_sub_bind PF08032.12 ORX72937.1 - 0.039 14.2 0.0 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Ribosomal_S4e PF00900.20 ORX72938.1 - 6.5e-35 118.9 0.1 1.3e-34 117.9 0.1 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 ORX72938.1 - 4.8e-26 90.1 0.1 8.6e-26 89.3 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 ORX72938.1 - 5.2e-20 71.3 7.2 9.7e-20 70.4 7.2 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 ORX72938.1 - 2.7e-06 27.0 0.1 5.5e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 ORX72938.1 - 2.7e-05 24.0 5.0 2.7e-05 24.0 5.0 3.1 5 0 0 5 5 5 1 KOW motif Sipho_tail PF05709.11 ORX72938.1 - 0.13 11.7 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein F-actin_cap_A PF01267.17 ORX72939.1 - 1.9e-82 276.7 0.0 1.7e-80 270.3 0.0 2.2 1 1 0 1 1 1 1 F-actin capping protein alpha subunit MutL_C PF08676.11 ORX72939.1 - 1.7e-21 76.5 0.1 3.7e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ORX72939.1 - 1.2e-18 66.9 0.0 2.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ORX72939.1 - 3.7e-08 33.3 0.0 6.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX72939.1 - 7e-06 26.5 0.0 2.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Bax1-I PF01027.20 ORX72940.1 - 3.3e-17 63.0 17.6 4.4e-17 62.6 17.6 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Transferase PF02458.15 ORX72941.1 - 3.3e-09 35.9 0.0 0.0018 17.0 0.0 2.1 2 0 0 2 2 2 2 Transferase family Transferase PF02458.15 ORX72942.1 - 6.3e-19 67.9 0.0 5.7e-13 48.3 0.0 2.7 1 1 1 2 2 2 2 Transferase family IreB PF06135.12 ORX72946.1 - 0.16 12.2 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 IreB regulatory phosphoprotein EF_assoc_2 PF08356.12 ORX72947.1 - 7.7e-35 118.8 0.0 1.6e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 ORX72947.1 - 2.8e-24 85.6 0.0 6.3e-15 55.1 0.0 2.4 2 0 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 ORX72947.1 - 8.4e-24 83.0 0.0 1.9e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Roc PF08477.13 ORX72947.1 - 8.8e-17 61.4 0.0 1.5e-09 38.1 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX72947.1 - 9.1e-11 41.8 0.1 0.0001 22.4 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 ORX72947.1 - 7.7e-08 33.0 0.0 0.0014 19.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX72947.1 - 5.6e-07 29.2 0.1 0.025 14.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX72947.1 - 1.2e-06 29.0 0.0 0.024 15.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX72947.1 - 2.2e-06 28.0 0.2 0.13 12.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain Arf PF00025.21 ORX72947.1 - 2.6e-06 27.0 0.3 0.057 12.9 0.4 3.0 2 1 0 2 2 2 2 ADP-ribosylation factor family EF-hand_7 PF13499.6 ORX72947.1 - 3.4e-06 27.4 0.0 0.014 15.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair RsgA_GTPase PF03193.16 ORX72947.1 - 4.2e-06 26.8 0.2 0.02 14.8 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 ORX72947.1 - 5.8e-06 26.9 0.0 0.048 14.2 0.0 2.5 2 1 0 2 2 2 2 ABC transporter EF-hand_1 PF00036.32 ORX72947.1 - 6.2e-06 25.4 2.9 0.0083 15.6 0.2 2.7 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.23 ORX72947.1 - 1.1e-05 25.6 1.2 0.049 13.7 0.1 3.1 2 2 1 3 3 3 2 Dynamin family AAA_28 PF13521.6 ORX72947.1 - 2.4e-05 24.6 0.0 0.34 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain EF-hand_6 PF13405.6 ORX72947.1 - 3.6e-05 23.4 0.7 0.26 11.3 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain AAA PF00004.29 ORX72947.1 - 5.8e-05 23.5 0.0 0.34 11.3 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 ORX72947.1 - 5.9e-05 22.5 0.0 0.067 12.5 0.0 2.2 2 0 0 2 2 2 2 Septin AAA_7 PF12775.7 ORX72947.1 - 0.00012 21.6 0.0 0.25 10.9 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ORX72947.1 - 0.00023 21.2 0.0 0.033 14.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 ORX72947.1 - 0.00028 20.6 0.3 0.29 10.8 0.1 2.3 2 0 0 2 2 2 2 Guanylate kinase RNA_helicase PF00910.22 ORX72947.1 - 0.00034 21.0 0.0 0.52 10.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 ORX72947.1 - 0.00076 19.4 0.0 0.97 9.3 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 ORX72947.1 - 0.00079 19.6 0.0 2 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ORX72947.1 - 0.0025 17.6 0.0 0.45 10.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ORX72947.1 - 0.0027 16.9 0.0 0.46 9.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AIG1 PF04548.16 ORX72947.1 - 0.0029 16.9 0.1 0.0071 15.7 0.1 1.6 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 ORX72947.1 - 0.0031 17.0 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ORX72947.1 - 0.004 17.0 1.9 6 6.6 0.0 3.9 3 1 1 4 4 4 0 Conserved hypothetical ATP binding protein Ploopntkinase3 PF18751.1 ORX72947.1 - 0.0041 17.1 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 cobW PF02492.19 ORX72947.1 - 0.0041 16.7 0.6 3.1 7.4 0.0 3.3 2 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 ORX72947.1 - 0.0049 16.1 0.0 0.23 10.6 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain TsaE PF02367.17 ORX72947.1 - 0.007 16.4 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ORX72947.1 - 0.008 15.5 0.0 1.3 8.3 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 ORX72947.1 - 0.0095 16.5 0.0 2.5 8.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain EF-hand_5 PF13202.6 ORX72947.1 - 0.017 14.6 1.9 0.25 10.9 0.3 2.5 2 0 0 2 2 2 0 EF hand AAA_14 PF13173.6 ORX72947.1 - 0.017 15.1 0.0 5.6 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ORX72947.1 - 0.019 14.7 0.1 6.7 6.4 0.1 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SMC_N PF02463.19 ORX72947.1 - 0.023 14.2 0.0 0.66 9.4 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MCM PF00493.23 ORX72947.1 - 0.028 13.5 0.1 0.092 11.8 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain EF-hand_10 PF14788.6 ORX72947.1 - 0.04 13.8 0.9 0.069 13.0 0.1 1.8 2 0 0 2 2 1 0 EF hand TniB PF05621.11 ORX72947.1 - 0.047 13.1 0.0 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.17 ORX72947.1 - 0.055 13.2 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein EF-hand_8 PF13833.6 ORX72947.1 - 0.057 13.3 0.5 0.22 11.4 0.2 2.1 2 0 0 2 2 1 0 EF-hand domain pair AAA_25 PF13481.6 ORX72947.1 - 0.059 13.0 0.0 3.1 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 ORX72947.1 - 0.06 13.2 0.3 12 5.9 0.0 2.6 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 ORX72947.1 - 0.06 12.9 0.8 1.4 8.5 0.6 2.7 2 1 0 2 2 2 0 Ferrous iron transport protein B VirE PF05272.11 ORX72947.1 - 0.061 13.0 0.0 1.5 8.5 0.0 2.3 2 1 0 2 2 2 0 Virulence-associated protein E AAA_15 PF13175.6 ORX72947.1 - 0.065 12.9 0.0 12 5.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 ORX72947.1 - 0.076 12.8 0.0 4.2 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase_2 PF01637.18 ORX72947.1 - 0.084 12.8 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Pox_A32 PF04665.12 ORX72947.1 - 0.13 11.7 0.0 14 5.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein Viral_helicase1 PF01443.18 ORX72947.1 - 0.13 12.0 0.0 6.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SRP54 PF00448.22 ORX72947.1 - 0.13 11.8 0.5 30 4.1 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Choline_transpo PF04515.12 ORX72948.1 - 1.9e-32 112.8 16.0 1.9e-32 112.8 16.0 2.1 3 0 0 3 3 3 1 Plasma-membrane choline transporter Serinc PF03348.15 ORX72949.1 - 3.9e-137 457.7 9.3 4.4e-137 457.5 9.3 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF2569 PF10754.9 ORX72949.1 - 3.9 7.9 19.0 0.043 14.3 2.5 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2569) DUF805 PF05656.14 ORX72949.1 - 8.4 6.9 12.7 1.2 9.6 5.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF805) Fumble PF03630.14 ORX72950.1 - 4.6e-127 423.8 0.1 6.4e-127 423.3 0.1 1.1 1 0 0 1 1 1 1 Fumble DUF89 PF01937.19 ORX72950.1 - 1.9e-20 73.1 0.0 3e-19 69.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function DUF89 Zds_C PF08632.10 ORX72951.1 - 7.4e-25 86.5 0.2 1.7e-24 85.3 0.2 1.6 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term WXG100 PF06013.12 ORX72952.1 - 9.8e-07 28.9 5.4 2.5e-06 27.6 5.4 1.6 1 1 0 1 1 1 1 Proteins of 100 residues with WXG PPE PF00823.19 ORX72952.1 - 5.1e-05 23.4 0.8 7.6e-05 22.9 0.8 1.2 1 0 0 1 1 1 1 PPE family DUF1140 PF06600.11 ORX72952.1 - 0.0049 17.3 0.1 0.0063 16.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1140) Seryl_tRNA_N PF02403.22 ORX72952.1 - 0.0054 17.0 0.4 0.0071 16.6 0.4 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain T7SS_ESX_EspC PF10824.8 ORX72952.1 - 0.016 15.7 2.5 0.027 14.9 2.5 1.3 1 0 0 1 1 1 0 Excreted virulence factor EspC, type VII ESX diderm His_Phos_2 PF00328.22 ORX72954.1 - 1.8e-16 60.5 0.0 2.1e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) TPT PF03151.16 ORX72956.1 - 4.6e-06 26.2 14.8 5.2e-06 26.0 14.8 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ORX72956.1 - 0.00045 19.5 14.7 0.0009 18.5 14.7 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX72956.1 - 0.0019 18.4 7.7 0.0019 18.4 7.7 2.2 2 0 0 2 2 2 1 EamA-like transporter family Y_phosphatase2 PF03162.13 ORX72958.1 - 1.7e-59 200.1 0.0 2e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX72958.1 - 1.4e-07 31.8 0.0 2.1e-07 31.2 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX72958.1 - 0.00023 21.0 0.1 0.0006 19.6 0.1 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX72958.1 - 0.00041 20.0 0.0 0.00052 19.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MtN3_slv PF03083.16 ORX72960.1 - 8e-30 102.7 7.3 6.4e-15 55.0 0.6 2.1 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 ORX72960.1 - 9.6e-07 28.8 2.4 0.00048 20.2 0.4 2.9 2 1 0 2 2 2 2 Lipid A Biosynthesis N-terminal domain RRM_1 PF00076.22 ORX72961.1 - 4.4e-19 68.1 0.0 5.2e-13 48.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX72961.1 - 0.00011 22.0 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 ORX72961.1 - 0.045 14.0 0.2 15 5.8 0.2 2.5 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter DUF1866 PF08952.11 ORX72961.1 - 0.048 13.5 0.0 0.48 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) Metallophos PF00149.28 ORX72962.1 - 1.3e-34 120.5 0.0 1.8e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX72962.1 - 1.7e-15 57.2 0.0 3.1e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SSP160 PF06933.11 ORX72962.1 - 0.33 9.1 8.6 0.52 8.4 8.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 XRN_M PF17846.1 ORX72962.1 - 0.9 8.4 3.8 1.4 7.8 3.8 1.2 1 0 0 1 1 1 0 Xrn1 helical domain SAPS PF04499.15 ORX72962.1 - 1.6 7.5 5.8 3 6.5 5.8 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein JTB PF05439.12 ORX72963.1 - 1.7e-06 28.1 0.7 2.9e-06 27.3 0.7 1.4 1 1 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Mce4_CUP1 PF11887.8 ORX72963.1 - 0.23 10.9 0.1 0.24 10.8 0.1 1.1 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative RRM_1 PF00076.22 ORX72964.1 - 4e-17 61.8 0.1 6.3e-17 61.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) His_biosynth PF00977.21 ORX72965.1 - 2.4e-36 125.3 0.0 3.2e-36 124.9 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein PMT PF02366.18 ORX72966.1 - 4.3e-78 262.3 15.0 4.3e-78 262.3 15.0 2.4 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX72966.1 - 1.6e-52 178.0 14.6 1.6e-52 178.0 14.6 2.3 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX72966.1 - 3.2e-23 82.5 0.0 1.9e-22 80.1 0.0 2.1 1 1 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ORX72966.1 - 3.1e-06 27.5 10.2 3.1e-06 27.5 10.2 3.4 3 2 1 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Ins145_P3_rec PF08709.11 ORX72966.1 - 0.011 15.0 0.0 0.039 13.2 0.0 1.8 1 1 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Lung_7-TM_R PF06814.13 ORX72967.1 - 6.3e-09 35.5 0.2 9.8e-09 34.9 0.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ORX72967.1 - 6.5e-05 22.5 0.2 8.7e-05 22.1 0.2 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Fungal_trans PF04082.18 ORX72968.1 - 3.5e-21 75.4 0.1 3.5e-10 39.4 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain LRR_4 PF12799.7 ORX72970.1 - 0.18 12.2 0.7 18 5.9 0.0 3.4 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX72972.1 - 0.00031 20.5 0.2 0.00067 19.5 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX72972.1 - 0.00049 19.9 0.0 0.00092 19.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ORX72972.1 - 0.01 15.7 0.1 0.027 14.3 0.1 1.7 1 0 0 1 1 1 0 F-box MMM1 PF10296.9 ORX72973.1 - 1.3e-07 31.0 0.2 8e-05 21.8 0.1 2.6 2 1 1 3 3 3 2 Maintenance of mitochondrial morphology protein 1 RcpC PF16976.5 ORX72973.1 - 0.14 12.2 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB RPEL PF02755.15 ORX72976.1 - 9e-22 76.1 16.8 2e-08 33.7 1.9 3.5 3 0 0 3 3 3 3 RPEL repeat DUF2737 PF10930.8 ORX72976.1 - 0.1 12.2 0.6 12 5.6 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2737) DUF4888 PF16229.5 ORX72976.1 - 0.16 11.9 0.2 10 6.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4888) A_deamin PF02137.18 ORX72977.1 - 1.8e-71 241.3 0.0 2e-71 241.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain DUF1358 PF07096.11 ORX72978.1 - 0.0046 16.9 1.2 0.01 15.8 1.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1358) MCM2_N PF12619.8 ORX72978.1 - 0.0072 16.6 2.4 0.01 16.1 2.4 1.3 1 0 0 1 1 1 1 Mini-chromosome maintenance protein 2 Phage_Gp17 PF17549.2 ORX72978.1 - 0.051 13.6 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Gene Product 17 Orbi_NS3 PF01616.16 ORX72979.1 - 0.05 13.3 0.1 0.09 12.5 0.1 1.3 1 1 0 1 1 1 0 Orbivirus NS3 CAP PF00188.26 ORX72980.1 - 1.5e-10 42.0 0.1 2.2e-10 41.4 0.1 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF3734 PF12536.8 ORX72980.1 - 0.13 12.6 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Patatin phospholipase CAP PF00188.26 ORX72981.1 - 1.3e-08 35.7 1.5 1.7e-08 35.4 1.5 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ceramidase PF05875.12 ORX72982.1 - 2.3e-54 184.6 17.0 2.6e-54 184.4 17.0 1.0 1 0 0 1 1 1 1 Ceramidase SgrT PF15894.5 ORX72982.1 - 0.076 13.0 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT DAO PF01266.24 ORX72983.1 - 4.8e-48 164.5 0.8 5.9e-48 164.2 0.8 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX72983.1 - 3.3e-05 23.3 0.6 0.017 14.4 0.0 2.5 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX72983.1 - 8e-05 22.7 0.2 0.0086 16.1 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ORX72983.1 - 0.00018 21.6 0.0 0.00063 19.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ORX72983.1 - 0.00031 20.2 0.1 0.00069 19.0 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 ORX72983.1 - 0.00066 19.0 0.0 0.0038 16.5 0.0 2.0 2 0 0 2 2 2 1 Thi4 family DUF3875 PF12991.7 ORX72983.1 - 0.0033 17.3 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function, B. Theta Gene description (DUF3875) FAD_binding_2 PF00890.24 ORX72983.1 - 0.0064 15.6 1.5 0.026 13.6 1.5 2.0 1 1 0 1 1 1 1 FAD binding domain K_oxygenase PF13434.6 ORX72983.1 - 0.12 11.4 0.0 0.28 10.3 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Aa_trans PF01490.18 ORX72984.1 - 1.1e-72 245.0 27.2 1.2e-72 244.8 27.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ChapFlgA_N PF17656.1 ORX72984.1 - 0.17 12.0 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 FlgA N-terminal domain Kinesin PF00225.23 ORX72985.1 - 8.7e-106 353.6 4.0 1.8e-105 352.5 0.0 2.1 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX72985.1 - 6e-23 81.4 0.2 2.2e-20 73.1 0.0 3.1 2 1 0 2 2 2 1 Microtubule binding RasGAP_C PF03836.15 ORX72985.1 - 0.0066 16.6 6.8 0.019 15.1 6.8 1.9 1 0 0 1 1 1 1 RasGAP C-terminus PIF1 PF05970.14 ORX72985.1 - 0.0079 15.4 1.1 0.012 14.8 0.0 1.8 2 0 0 2 2 2 1 PIF1-like helicase DUF573 PF04504.14 ORX72985.1 - 0.043 14.5 9.7 0.46 11.2 2.1 3.7 2 2 1 3 3 3 0 Protein of unknown function, DUF573 ResIII PF04851.15 ORX72985.1 - 0.093 12.7 2.0 4.2 7.3 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Leu_zip PF15294.6 ORX72985.1 - 0.14 11.7 23.6 0.038 13.5 15.8 2.4 1 1 1 2 2 2 0 Leucine zipper Tropomyosin_1 PF12718.7 ORX72985.1 - 0.17 12.0 27.6 0.5 10.5 0.7 3.1 1 1 1 3 3 3 0 Tropomyosin like Prominin PF05478.11 ORX72985.1 - 0.24 9.3 9.5 0.34 8.8 9.5 1.1 1 0 0 1 1 1 0 Prominin DHHA1 PF02272.19 ORX72985.1 - 0.48 10.8 6.4 0.16 12.4 2.6 2.3 2 0 0 2 2 2 0 DHHA1 domain CRT10 PF08728.10 ORX72985.1 - 0.71 8.0 9.3 1 7.4 9.3 1.1 1 0 0 1 1 1 0 CRT10 DUF1664 PF07889.12 ORX72985.1 - 0.78 9.8 14.3 3.6 7.6 0.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 ORX72985.1 - 2.1 7.2 7.2 3.4 6.5 7.2 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DLP_helical PF18709.1 ORX72985.1 - 4.2 6.5 16.3 0.38 9.9 6.8 2.4 1 1 1 2 2 2 0 Dynamin-like helical domain LAG1-DNAbind PF09271.11 ORX72985.1 - 5.5 7.6 6.9 3.3 8.3 4.0 2.1 2 0 0 2 2 2 0 LAG1, DNA binding V_ATPase_I PF01496.19 ORX72985.1 - 5.7 4.7 8.9 8 4.2 8.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Coatomer_E PF04733.14 ORX72988.1 - 7.5e-49 166.7 2.1 5.4e-46 157.3 2.1 2.8 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 ORX72988.1 - 0.00021 21.7 18.2 0.024 15.2 0.2 4.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX72988.1 - 0.0023 18.2 0.3 3.2 8.3 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX72988.1 - 0.01 15.9 5.6 0.61 10.3 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX72988.1 - 0.013 15.8 5.8 0.15 12.3 0.1 3.4 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX72988.1 - 0.023 14.7 1.0 0.84 9.8 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ORX72988.1 - 0.12 12.5 0.1 8.6 6.4 0.0 2.9 3 0 0 3 3 3 0 Putative TPR-like repeat Fis1_TPR_C PF14853.6 ORX72988.1 - 0.12 12.5 0.8 5.8 7.1 0.1 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 ORX72988.1 - 0.58 10.5 13.3 2.4 8.5 1.0 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX72988.1 - 9.7 7.3 25.5 0.17 12.8 1.7 5.4 5 1 2 7 7 7 0 Tetratricopeptide repeat Pkinase PF00069.25 ORX72989.1 - 3.2e-60 203.7 0.3 1.2e-27 96.9 0.0 3.5 3 0 0 3 3 3 3 Protein kinase domain HGTP_anticodon2 PF12745.7 ORX72989.1 - 5e-33 114.7 5.1 9.3e-32 110.6 0.0 3.3 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase_Tyr PF07714.17 ORX72989.1 - 2e-28 99.4 0.2 4.3e-14 52.4 0.0 3.8 3 1 0 3 3 3 3 Protein tyrosine kinase TRAM_LAG1_CLN8 PF03798.16 ORX72989.1 - 1.4e-18 67.4 9.2 2.3e-18 66.7 9.2 1.3 1 0 0 1 1 1 1 TLC domain RWD PF05773.22 ORX72989.1 - 8.5e-09 35.7 0.0 2.7e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 RWD domain FTA2 PF13095.6 ORX72989.1 - 0.00031 20.4 1.3 0.64 9.6 0.0 3.6 5 0 0 5 5 5 2 Kinetochore Sim4 complex subunit FTA2 tRNA-synt_His PF13393.6 ORX72989.1 - 0.0013 18.0 7.6 0.0024 17.2 2.2 3.1 2 1 0 2 2 2 1 Histidyl-tRNA synthetase Kdo PF06293.14 ORX72989.1 - 0.0032 16.8 0.1 1.1 8.6 0.0 2.9 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Auxin_resp PF06507.13 ORX72989.1 - 0.15 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Auxin response factor DUF1325 PF07039.11 ORX72990.1 - 1.1e-05 25.6 0.0 1.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain COMPASS-Shg1 PF05205.12 ORX72990.1 - 0.00026 21.6 0.0 0.00044 20.9 0.0 1.3 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 DUF4537 PF15057.6 ORX72990.1 - 0.0022 18.0 0.0 0.021 14.8 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4537) CytochromB561_N PF09786.9 ORX72990.1 - 2.5 7.0 6.0 3.6 6.5 6.0 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Molybdopterin PF00384.22 ORX72991.1 - 7.7e-63 212.9 0.0 3.9e-33 115.1 0.0 2.9 1 1 1 2 2 2 2 Molybdopterin oxidoreductase Fer2_4 PF13510.6 ORX72991.1 - 4e-20 71.6 0.1 1.3e-19 70.0 0.1 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 ORX72991.1 - 4.7e-18 64.4 0.3 4.7e-18 64.4 0.3 1.8 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 ORX72991.1 - 2.3e-09 37.1 1.9 3.7e-09 36.4 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 ORX72991.1 - 6.2e-05 23.6 5.0 0.00018 22.1 5.0 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal TPP_enzyme_M PF00205.22 ORX72991.1 - 0.0024 17.6 0.0 0.12 12.1 0.0 2.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 ORX72991.1 - 0.21 11.5 1.0 7.3 6.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 ORX72991.1 - 0.49 10.5 2.2 9.5 6.4 2.2 2.7 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Vps16_N PF04841.13 ORX72992.1 - 2.3e-90 303.3 0.0 3.1e-90 302.9 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 ORX72992.1 - 1.3e-74 251.1 2.0 2e-74 250.5 2.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region NHL PF01436.21 ORX72992.1 - 0.014 15.5 0.1 0.037 14.1 0.1 1.8 1 0 0 1 1 1 0 NHL repeat ANAPC4_WD40 PF12894.7 ORX72992.1 - 0.047 14.0 0.0 14 6.1 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX72994.1 - 7.5e-21 74.1 13.8 8.7e-06 26.4 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Striatin PF08232.12 ORX72994.1 - 3e-14 53.9 0.7 3e-14 53.9 0.7 2.5 2 1 0 2 2 2 1 Striatin family ANAPC4_WD40 PF12894.7 ORX72994.1 - 3.8e-05 23.9 0.0 0.61 10.4 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Rit1_C PF17184.4 ORX72995.1 - 1e-83 281.0 0.1 4.5e-81 272.3 0.1 2.2 1 1 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ORX72995.1 - 6.8e-30 103.6 0.0 1.4e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain DSPc PF00782.20 ORX72995.1 - 2.7e-08 33.7 0.0 4.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ORX72995.1 - 0.054 13.4 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 ORX72995.1 - 0.13 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Diphthamide_syn PF01866.17 ORX72996.1 - 1.1e-97 327.2 0.1 1.4e-97 326.8 0.1 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Kelch_6 PF13964.6 ORX72997.1 - 3.3e-19 68.4 2.5 1e-09 38.3 0.2 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ORX72997.1 - 2.9e-16 59.0 0.5 3.9e-06 26.7 0.1 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 ORX72997.1 - 1.4e-15 57.0 8.8 5.1e-07 29.6 0.1 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX72997.1 - 3.6e-14 52.1 1.4 9.7e-06 25.1 0.2 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ORX72997.1 - 1e-13 50.7 5.1 9e-07 28.6 0.1 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ORX72997.1 - 1.1e-12 47.8 15.8 1.4e-05 25.3 0.1 7.5 6 1 1 7 7 7 2 Galactose oxidase, central domain ACC_epsilon PF13822.6 ORX72997.1 - 0.46 11.2 3.7 23 5.7 0.2 3.1 3 0 0 3 3 3 0 Acyl-CoA carboxylase epsilon subunit Glyco_hydro_18 PF00704.28 ORX72998.1 - 2.1e-65 221.5 3.4 2.4e-65 221.3 3.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 OCRE PF17780.1 ORX72998.1 - 0.15 12.1 3.8 0.64 10.1 1.8 2.3 2 0 0 2 2 2 0 OCRE domain FAM72 PF14976.6 ORX72999.1 - 2.6e-09 37.4 5.2 2.6e-09 37.4 5.2 1.3 1 1 0 1 1 1 1 FAM72 protein GST_C PF00043.25 ORX73000.1 - 1.1e-10 41.6 0.0 1.5e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX73000.1 - 3.5e-08 33.5 0.0 7.5e-08 32.5 0.0 1.6 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX73000.1 - 1.4e-07 31.7 0.0 3.7e-07 30.4 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX73000.1 - 1.2e-05 25.3 0.5 1.8e-05 24.7 0.5 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX73000.1 - 2e-05 24.9 0.0 4.4e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX73000.1 - 0.00046 20.4 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF3533 PF12051.8 ORX73001.1 - 1.2e-39 136.3 13.4 1.5e-39 136.0 13.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Sec1 PF00995.23 ORX73002.1 - 2e-105 354.2 0.0 2.3e-105 354.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ribosomal_60s PF00428.19 ORX73002.1 - 0.87 10.2 5.6 2.2 8.9 5.6 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ribonuclease_T2 PF00445.18 ORX73003.1 - 2.6e-36 125.5 1.4 3.6e-36 125.1 1.4 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family RMMBL PF07521.12 ORX73003.1 - 0.2 11.6 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain GDPD PF03009.17 ORX73005.1 - 4e-26 92.3 0.0 1.7e-25 90.3 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Wzy_C PF04932.15 ORX73005.1 - 0.15 11.7 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 O-Antigen ligase GDPD PF03009.17 ORX73006.1 - 5.7e-27 95.1 0.0 3.6e-21 76.1 0.0 2.1 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family HisG PF01634.18 ORX73007.1 - 2.5e-52 177.1 0.4 3.6e-52 176.6 0.4 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 ORX73007.1 - 1.4e-27 95.7 0.0 2.7e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 ORX73007.1 - 0.0093 15.9 0.1 0.013 15.4 0.1 1.3 1 0 0 1 1 1 1 NMT1/THI5 like Band_7 PF01145.25 ORX73008.1 - 2.9e-29 102.3 6.3 9.8e-29 100.6 6.3 1.9 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 ORX73008.1 - 2.5e-25 88.3 0.8 7.8e-25 86.7 0.8 1.9 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 ORX73008.1 - 0.05 13.3 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family DUF2161 PF09929.9 ORX73008.1 - 0.11 12.7 1.7 0.23 11.6 1.7 1.5 1 0 0 1 1 1 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) MRP-S26 PF14943.6 ORX73009.1 - 0.02 14.8 1.3 0.02 14.8 1.3 2.3 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 PBP1_TM PF14812.6 ORX73010.1 - 1.8 9.0 8.2 3.3 8.1 8.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L39 PF00832.20 ORX73012.1 - 5.4e-21 73.9 10.4 6.3e-21 73.7 10.4 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Utp14 PF04615.13 ORX73013.1 - 7.7e-128 428.2 83.6 1.3e-83 282.0 49.3 3.6 2 2 0 3 3 3 2 Utp14 protein Ribosomal_L2_C PF03947.18 ORX73014.1 - 1.5e-43 148.0 2.6 2.6e-43 147.2 2.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ORX73014.1 - 2.9e-17 62.4 0.0 6.5e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Pkinase PF00069.25 ORX73016.1 - 1.1e-63 215.1 0.0 1.2e-63 214.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73016.1 - 2.7e-31 108.8 0.0 3.5e-31 108.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX73016.1 - 0.0034 16.2 0.1 0.0056 15.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX73016.1 - 0.0037 16.6 0.0 0.0076 15.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX73016.1 - 0.036 13.4 0.1 0.057 12.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ORX73016.1 - 0.062 12.3 0.2 0.14 11.1 0.1 1.6 1 1 0 2 2 2 0 Poxvirus serine/threonine protein kinase Adeno_PIX PF03955.14 ORX73016.1 - 0.083 13.1 3.0 0.2 11.8 3.0 1.7 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) RskA PF10099.9 ORX73016.1 - 0.18 12.1 8.2 0.27 11.5 8.2 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA adh_short PF00106.25 ORX73018.1 - 7.6e-33 113.6 0.0 1.1e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73018.1 - 3.6e-28 98.7 0.2 4.7e-28 98.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX73018.1 - 2e-07 31.1 0.0 3.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX73018.1 - 0.094 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Dimeth_Pyl PF09505.10 ORX73018.1 - 0.1 11.1 0.0 0.16 10.5 0.0 1.3 1 0 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) DEAD PF00270.29 ORX73019.1 - 1.2e-28 100.1 0.0 2.1e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX73019.1 - 1.8e-13 50.8 0.0 4.8e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1998 PF09369.10 ORX73019.1 - 4.1e-13 49.9 2.6 1e-12 48.6 2.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) ResIII PF04851.15 ORX73019.1 - 5.9e-09 36.1 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3422 PF11902.8 ORX73021.1 - 0.01 15.0 0.1 0.013 14.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3422) Aa_trans PF01490.18 ORX73022.1 - 9e-42 143.2 35.3 5.8e-28 97.7 20.9 2.6 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Aa_trans PF01490.18 ORX73023.1 - 1.7e-49 168.7 24.5 2e-49 168.4 24.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX73023.1 - 3.2e-06 26.2 31.6 3.2e-06 26.2 31.6 2.2 1 1 0 2 2 2 2 Amino acid permease UPF0182 PF03699.13 ORX73023.1 - 2.7 6.0 10.0 0.41 8.7 2.7 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) E1_dh PF00676.20 ORX73024.1 - 2.6e-117 391.1 0.4 3.4e-117 390.7 0.4 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ORX73024.1 - 2.8e-06 26.7 0.0 4.7e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ORX73024.1 - 0.0056 16.5 1.7 0.0056 16.5 1.7 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DD_K PF12121.8 ORX73024.1 - 0.093 12.9 0.8 0.28 11.3 0.8 1.8 1 0 0 1 1 1 0 Dermaseptin UDG PF03167.19 ORX73025.1 - 3.1e-23 82.5 0.0 4.8e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Ntox27 PF15531.6 ORX73026.1 - 0.032 14.1 0.1 0.045 13.6 0.1 1.5 1 1 0 1 1 1 0 Bacterial toxin 27 DASH_Hsk3 PF08227.11 ORX73026.1 - 0.063 13.6 0.8 0.98 9.8 0.5 2.3 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like SNF2_N PF00176.23 ORX73027.1 - 1.3e-71 241.2 0.0 2.5e-71 240.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX73027.1 - 1.6e-18 67.0 0.0 8.7e-18 64.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX73027.1 - 2e-11 44.2 0.0 5.4e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX73027.1 - 1.4e-07 31.0 0.8 4.8e-07 29.2 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 ORX73027.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase OSTbeta PF15048.6 ORX73027.1 - 5.6 7.1 6.4 88 3.3 0.0 3.0 3 1 0 3 3 3 0 Organic solute transporter subunit beta protein p450 PF00067.22 ORX73028.1 - 5.7e-64 216.6 0.0 7.7e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cactin_mid PF10312.9 ORX73028.1 - 0.03 14.0 0.1 0.046 13.4 0.1 1.2 1 0 0 1 1 1 0 Conserved mid region of cactin TAXi_C PF14541.6 ORX73028.1 - 0.17 11.7 0.2 0.29 10.9 0.2 1.3 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal p450 PF00067.22 ORX73029.1 - 1.2e-42 146.3 0.0 5.1e-34 117.8 0.0 3.0 1 1 2 3 3 3 3 Cytochrome P450 GREB1 PF15782.5 ORX73030.1 - 0.094 9.8 0.0 0.11 9.6 0.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer p450 PF00067.22 ORX73031.1 - 3.4e-48 164.5 0.0 1.4e-42 146.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 ADH_zinc_N PF00107.26 ORX73032.1 - 1.3e-06 28.5 0.1 0.037 14.0 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 ORX73032.1 - 0.063 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Arrestin_N PF00339.29 ORX73033.1 - 0.00017 21.7 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain GSCFA PF08885.11 ORX73033.1 - 0.015 14.9 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 GSCFA family 7tm_3 PF00003.22 ORX73035.1 - 0.00032 20.5 17.8 0.00072 19.3 16.8 2.1 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR RGS PF00615.19 ORX73035.1 - 0.011 16.0 0.1 0.084 13.1 0.1 2.1 1 1 0 1 1 1 0 Regulator of G protein signaling domain p450 PF00067.22 ORX73036.1 - 1.2e-57 195.7 0.0 1.5e-57 195.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aa_trans PF01490.18 ORX73038.1 - 1.5e-59 201.8 29.4 1.6e-59 201.6 29.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Prion_bPrPp PF11587.8 ORX73038.1 - 1.7 8.6 4.4 18 5.3 0.9 3.0 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal COX15-CtaA PF02628.15 ORX73039.1 - 7.1e-18 64.8 11.8 2.3e-17 63.1 11.8 1.9 1 1 0 1 1 1 1 Cytochrome oxidase assembly protein F-box-like PF12937.7 ORX73039.1 - 7.1e-06 25.8 1.0 2.3e-05 24.2 1.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX73039.1 - 0.0028 17.5 0.1 0.0069 16.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain Zn_clus PF00172.18 ORX73040.1 - 9.3e-10 38.5 13.3 1.8e-09 37.5 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RGS PF00615.19 ORX73046.1 - 9.8e-06 25.8 0.6 7.2e-05 23.0 0.6 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain 7tm_3 PF00003.22 ORX73046.1 - 2.5e-05 24.1 17.2 6.2e-05 22.8 17.2 1.7 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ATP-synt_Z PF16594.5 ORX73046.1 - 0.007 15.8 1.8 0.007 15.8 1.8 2.7 3 0 0 3 3 3 1 Putative AtpZ or ATP-synthase-associated UL41A PF17591.2 ORX73046.1 - 0.072 13.2 1.1 1.5 9.0 0.2 3.0 2 0 0 2 2 2 0 Herpesvirus UL41A EcoR124_C PF12008.8 ORX73047.1 - 0.058 13.1 0.1 0.063 12.9 0.1 1.0 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal Pox_polyA_pol_N PF12630.7 ORX73047.1 - 0.062 13.7 0.0 0.074 13.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain Gate PF07670.14 ORX73047.1 - 0.072 13.4 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Nucleoside recognition Glyco_hydro_35 PF01301.19 ORX73049.1 - 6.6e-97 324.9 3.9 8.6e-97 324.6 3.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Ras PF00071.22 ORX73050.1 - 4e-53 179.3 0.0 4.5e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX73050.1 - 3e-19 69.4 0.0 4.1e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX73050.1 - 3.8e-06 26.5 0.0 6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX73050.1 - 0.04 13.4 0.0 0.23 11.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Cys_Met_Meta_PP PF01053.20 ORX73051.1 - 2.3e-63 214.0 1.3 4.2e-62 209.9 1.3 2.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ORX73051.1 - 0.002 17.1 0.0 0.0038 16.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ORX73051.1 - 0.019 14.1 0.0 0.045 12.9 0.0 1.6 1 1 0 1 1 1 0 Aminotransferase class I and II MFS_1 PF07690.16 ORX73052.1 - 4e-31 108.2 81.4 2.7e-25 89.1 47.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TIM21 PF08294.11 ORX73059.1 - 1.6e-10 41.1 1.1 1.5e-09 37.8 0.5 2.4 2 1 0 2 2 2 1 TIM21 DUF4330 PF14221.6 ORX73060.1 - 0.24 11.6 1.7 0.32 11.2 0.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) RNA_pol_Rpb6 PF01192.22 ORX73060.1 - 0.27 11.2 1.0 0.96 9.4 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb6 TFIIA PF03153.13 ORX73060.1 - 2.1 8.3 14.3 2.6 7.9 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 ORX73061.1 - 0.072 12.4 14.8 0.06 12.7 14.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 ORX73062.1 - 0.2 10.8 20.4 0.24 10.5 20.4 1.1 1 0 0 1 1 1 0 SprA-related family Rrn6 PF10214.9 ORX73062.1 - 0.2 10.1 8.4 0.25 9.8 8.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 ORX73062.1 - 0.24 9.6 6.4 0.31 9.3 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF-3_zeta PF05091.12 ORX73062.1 - 0.9 8.4 5.9 1 8.3 5.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 ORX73062.1 - 1.6 8.6 15.9 1.7 8.5 15.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NST1 PF13945.6 ORX73062.1 - 1.8 8.7 9.8 0.08 13.0 3.2 1.8 2 0 0 2 2 2 0 Salt tolerance down-regulator Presenilin PF01080.17 ORX73062.1 - 1.8 7.3 7.1 2.1 7.1 7.1 1.1 1 0 0 1 1 1 0 Presenilin API5 PF05918.11 ORX73062.1 - 3.8 6.2 6.7 4.6 5.9 6.7 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Hamartin PF04388.12 ORX73062.1 - 8.9 4.8 9.1 11 4.6 9.1 1.1 1 0 0 1 1 1 0 Hamartin protein p450 PF00067.22 ORX73063.1 - 4e-62 210.5 0.0 1.3e-61 208.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 ORX73065.1 - 1.1e-75 254.6 0.0 1.3e-75 254.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NLE PF08154.12 ORX73066.1 - 0.086 13.4 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 NLE (NUC135) domain Aldo_ket_red PF00248.21 ORX73067.1 - 7.1e-61 206.0 0.0 8.2e-61 205.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Acyl-CoA_dh_1 PF00441.24 ORX73068.1 - 1e-51 175.1 4.1 1e-51 175.1 4.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX73068.1 - 3.2e-19 69.5 2.2 3.2e-19 69.5 2.2 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX73068.1 - 1.4e-07 31.6 0.4 0.014 15.5 0.0 2.8 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX73068.1 - 5.2e-06 27.1 0.6 0.028 15.1 0.1 2.9 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, N-terminal domain Nitrate_red_del PF02613.15 ORX73068.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Nitrate reductase delta subunit DMT_YdcZ PF04657.13 ORX73069.1 - 2.9e-27 95.7 10.3 3.3e-27 95.5 10.3 1.0 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ TctB PF07331.11 ORX73069.1 - 0.003 17.8 8.3 0.0038 17.5 8.3 1.1 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family Wzy_C PF04932.15 ORX73069.1 - 0.088 12.4 5.6 0.44 10.2 5.6 2.2 1 1 0 1 1 1 0 O-Antigen ligase DUF3341 PF11821.8 ORX73069.1 - 1.2 8.7 7.1 4.9 6.8 7.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) Peptidase_U4 PF03419.13 ORX73069.1 - 3.6 6.8 14.7 2.3 7.4 1.9 2.1 1 1 1 2 2 2 0 Sporulation factor SpoIIGA p450 PF00067.22 ORX73071.1 - 5.3e-56 190.3 0.0 8.9e-55 186.3 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 7tm_3 PF00003.22 ORX73072.1 - 6.1e-05 22.9 22.0 8.3e-05 22.4 22.0 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR LRR19-TM PF15176.6 ORX73072.1 - 0.43 10.6 1.3 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF2721 PF11026.8 ORX73072.1 - 1.4 8.8 5.9 3.8 7.4 5.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) MCU PF04678.13 ORX73073.1 - 0.058 13.5 0.1 0.08 13.0 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter 7tm_3 PF00003.22 ORX73074.1 - 0.031 14.0 14.2 0.038 13.7 14.2 1.1 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR 5TM-5TMR_LYT PF07694.12 ORX73074.1 - 0.58 9.7 7.3 0.27 10.7 2.7 2.3 1 1 2 3 3 3 0 5TMR of 5TMR-LYT 7tm_3 PF00003.22 ORX73078.1 - 0.00014 21.6 30.4 0.00019 21.3 30.4 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2561 PF10812.8 ORX73078.1 - 2.8 7.9 9.3 9.8 6.1 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2561) 7tm_3 PF00003.22 ORX73079.1 - 0.046 13.5 29.9 0.12 12.1 29.7 1.7 1 1 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF373 PF04123.13 ORX73079.1 - 0.091 12.2 13.2 0.0094 15.4 7.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF373) DUF2304 PF10066.9 ORX73079.1 - 3.5 7.9 17.2 0.19 12.0 8.7 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF202 PF02656.15 ORX73079.1 - 10 6.7 12.9 46 4.6 9.8 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DAO PF01266.24 ORX73080.1 - 1.4e-19 70.9 4.1 3.7e-16 59.7 4.1 3.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX73080.1 - 0.0093 16.4 0.0 0.016 15.7 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ORX73080.1 - 0.013 14.7 0.5 0.022 13.8 0.4 1.3 1 1 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 ORX73080.1 - 0.02 15.5 0.5 0.046 14.3 0.5 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX73080.1 - 0.034 13.4 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ORX73080.1 - 0.04 14.0 0.1 0.064 13.3 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ORX73080.1 - 0.041 13.5 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 ORX73080.1 - 0.11 11.7 0.1 0.27 10.4 0.1 1.6 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 ORX73080.1 - 0.17 11.2 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MRI PF15325.6 ORX73081.1 - 0.94 10.6 6.1 1.8 9.7 6.1 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection RGS PF00615.19 ORX73084.1 - 1.9e-08 34.6 0.8 1.4e-07 31.8 0.8 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain CoA_binding_3 PF13727.6 ORX73084.1 - 0.061 13.3 1.2 0.12 12.3 1.2 1.5 1 0 0 1 1 1 0 CoA-binding domain DUF4834 PF16118.5 ORX73084.1 - 0.19 12.7 0.9 0.83 10.7 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) YqhR PF11085.8 ORX73084.1 - 0.25 11.2 4.5 0.48 10.4 4.5 1.4 1 0 0 1 1 1 0 Conserved membrane protein YqhR CDC45 PF02724.14 ORX73089.1 - 0.29 9.4 2.2 0.36 9.1 2.2 1.1 1 0 0 1 1 1 0 CDC45-like protein CC190 PF15768.5 ORX73089.1 - 6.9 6.6 8.2 9.9 6.1 8.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 CPBP PF02517.16 ORX73090.1 - 8.3e-15 54.9 12.4 6.2e-14 52.1 12.4 2.4 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease Cpn60_TCP1 PF00118.24 ORX73091.1 - 5.5e-139 463.9 2.9 7.1e-139 463.6 2.9 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PrpR_N PF06506.11 ORX73091.1 - 0.031 13.8 0.0 0.1 12.2 0.0 1.8 1 0 0 1 1 1 0 Propionate catabolism activator PucR PF07905.11 ORX73091.1 - 0.045 14.0 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family EAL PF00563.20 ORX73091.1 - 0.049 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 EAL domain Git3 PF11710.8 ORX73092.1 - 0.0024 17.7 0.5 0.0027 17.5 0.5 1.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 TMIE PF16038.5 ORX73093.1 - 5.2 7.0 7.7 10 6.0 7.7 1.4 1 0 0 1 1 1 0 TMIE protein Aldolase_II PF00596.21 ORX73094.1 - 2.6e-31 109.0 0.0 1.2e-16 61.2 0.0 2.1 1 1 1 2 2 2 2 Class II Aldolase and Adducin N-terminal domain SUI1 PF01253.22 ORX73095.1 - 2.2e-25 89.0 0.3 2.7e-25 88.7 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF1180 PF06679.12 ORX73098.1 - 0.23 11.9 5.8 0.4 11.1 5.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DAO PF01266.24 ORX73099.1 - 3.1e-20 73.1 1.0 8.2e-20 71.7 1.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX73099.1 - 0.0068 16.6 0.1 0.019 15.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX73099.1 - 0.013 14.8 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX73099.1 - 0.018 15.6 0.2 0.043 14.4 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX73099.1 - 0.032 13.3 0.7 0.055 12.5 0.7 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.6 ORX73099.1 - 0.032 14.7 0.0 0.099 13.1 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding CBM65_1 PF18259.1 ORX73099.1 - 0.033 14.3 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate binding module 65 domain 1 zf-RING_2 PF13639.6 ORX73100.1 - 6.6e-13 48.8 7.0 1.1e-12 48.1 7.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX73100.1 - 5.8e-10 38.8 6.3 9.9e-10 38.1 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX73100.1 - 2.2e-09 37.5 5.3 4.1e-09 36.6 5.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX73100.1 - 1.7e-07 30.9 4.7 3e-07 30.2 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX73100.1 - 4.9e-07 29.4 6.1 1e-06 28.4 6.1 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX73100.1 - 2.8e-06 27.3 1.1 4.2e-06 26.7 0.5 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX73100.1 - 3.7e-06 26.7 4.2 5.6e-06 26.1 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 ORX73100.1 - 7.4e-05 22.8 2.8 0.00013 22.0 2.8 1.4 1 0 0 1 1 1 1 KIAA1045 RING finger zf-RING_5 PF14634.6 ORX73100.1 - 0.0002 21.2 5.0 0.00035 20.5 5.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX73100.1 - 0.0012 18.8 5.7 0.0027 17.7 5.7 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ORX73100.1 - 0.0014 18.4 6.7 0.003 17.4 6.7 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ORX73100.1 - 0.0038 16.8 5.8 0.0072 15.9 5.8 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX73100.1 - 0.032 14.4 6.3 0.12 12.6 6.3 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1180 PF06679.12 ORX73100.1 - 0.035 14.5 0.0 0.066 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RINGv PF12906.7 ORX73100.1 - 0.43 10.7 5.5 1 9.6 5.5 1.7 1 1 0 1 1 1 0 RING-variant domain zf-P11 PF03854.14 ORX73100.1 - 2.7 7.7 7.1 5.1 6.8 7.1 1.5 1 1 0 1 1 1 0 P-11 zinc finger DUF2939 PF11159.8 ORX73101.1 - 0.034 14.6 0.4 0.071 13.5 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) Hydantoinase_B PF02538.14 ORX73102.1 - 3 6.1 12.4 3.4 6.0 12.4 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase AAA_6 PF12774.7 ORX73103.1 - 1.9e-127 424.8 0.0 3.2e-126 420.7 0.0 2.8 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 ORX73103.1 - 1.8e-112 376.4 1.2 1.8e-112 376.4 1.2 3.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 ORX73103.1 - 3.7e-111 372.5 0.6 3.7e-111 372.5 0.6 2.3 3 0 0 3 3 1 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 ORX73103.1 - 6.7e-67 225.5 0.0 2.8e-66 223.5 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 ORX73103.1 - 1.5e-39 136.1 0.0 6.1e-39 134.0 0.0 2.1 2 0 0 2 2 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 ORX73103.1 - 9.2e-31 106.7 0.0 1.1e-23 83.6 0.0 5.8 5 1 0 5 5 5 1 P-loop containing dynein motor region AAA_9 PF12781.7 ORX73103.1 - 1.3e-29 102.9 9.5 3e-25 88.6 0.5 5.3 4 1 1 5 5 4 2 ATP-binding dynein motor region MT PF12777.7 ORX73103.1 - 3.8e-29 101.8 6.7 1.1e-28 100.3 6.7 1.7 1 1 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 ORX73103.1 - 1.3e-28 99.9 0.0 4.9e-28 98.0 0.0 2.0 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 ORX73103.1 - 2e-25 89.4 0.3 1.1e-12 48.1 0.0 6.6 5 2 0 5 5 4 3 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 ORX73103.1 - 8.3e-22 77.5 0.3 2.2e-19 69.7 0.0 4.0 3 1 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 ORX73103.1 - 5.7e-12 46.1 6.6 0.11 12.7 0.0 6.6 7 0 0 7 7 5 4 AAA domain AAA PF00004.29 ORX73103.1 - 9.3e-12 45.5 0.0 0.027 14.9 0.0 5.1 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ORX73103.1 - 8.4e-11 42.5 0.0 0.013 16.1 0.0 5.3 4 0 0 4 4 4 1 AAA domain AAA_33 PF13671.6 ORX73103.1 - 2.1e-10 40.9 2.4 0.094 12.9 0.0 6.7 6 0 0 6 6 5 2 AAA domain Dynein_AAA_lid PF17852.1 ORX73103.1 - 6.3e-09 36.0 0.0 2e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain FtsK_SpoIIIE PF01580.18 ORX73103.1 - 3.2e-08 33.2 0.0 0.021 14.2 0.0 3.8 3 0 0 3 3 3 2 FtsK/SpoIIIE family T2SSE PF00437.20 ORX73103.1 - 2.4e-07 30.1 0.0 0.0076 15.3 0.0 4.3 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_16 PF13191.6 ORX73103.1 - 8.3e-07 29.5 15.6 3.3 8.1 0.0 8.5 7 1 0 8 8 5 1 AAA ATPase domain Mg_chelatase PF01078.21 ORX73103.1 - 3.9e-06 26.4 1.5 0.38 10.1 0.0 4.4 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 ORX73103.1 - 7.8e-06 25.5 0.1 0.34 10.7 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_19 PF13245.6 ORX73103.1 - 3.5e-05 24.2 3.6 0.21 11.9 0.0 5.3 5 0 0 5 5 5 1 AAA domain AAA_30 PF13604.6 ORX73103.1 - 3.8e-05 23.5 0.4 8.7 6.0 0.0 5.5 5 0 0 5 5 5 0 AAA domain AAA_25 PF13481.6 ORX73103.1 - 0.00035 20.2 0.2 0.28 10.7 0.0 4.5 3 0 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.9 ORX73103.1 - 0.00071 18.6 0.1 2.1 7.1 0.0 3.7 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 ORX73103.1 - 0.00074 19.8 2.9 8.8 6.5 0.0 5.3 5 0 0 5 5 4 0 AAA domain Spc7 PF08317.11 ORX73103.1 - 0.00075 18.5 20.6 0.00081 18.4 9.3 3.9 3 0 0 3 3 3 1 Spc7 kinetochore protein RNA_helicase PF00910.22 ORX73103.1 - 0.0019 18.6 0.1 45 4.5 0.0 4.9 5 0 0 5 5 5 0 RNA helicase ABC_tran PF00005.27 ORX73103.1 - 0.0051 17.3 5.4 10 6.7 0.0 4.6 5 0 0 5 5 3 0 ABC transporter AAA_24 PF13479.6 ORX73103.1 - 0.0057 16.4 0.1 34 4.1 0.0 4.6 5 0 0 5 5 4 0 AAA domain IstB_IS21 PF01695.17 ORX73103.1 - 0.0062 16.3 0.2 1.8 8.3 0.0 4.0 4 0 0 4 4 4 1 IstB-like ATP binding protein RuvB_N PF05496.12 ORX73103.1 - 0.0095 15.7 0.5 0.88 9.3 0.0 3.8 5 0 0 5 5 4 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 ORX73103.1 - 0.01 15.8 1.9 20 5.0 0.0 4.7 4 0 0 4 4 4 0 NACHT domain Rad17 PF03215.15 ORX73103.1 - 0.01 15.8 0.0 13 5.6 0.0 3.8 4 0 0 4 4 3 0 Rad17 P-loop domain PduV-EutP PF10662.9 ORX73103.1 - 0.019 14.7 0.4 6.1 6.6 0.0 3.3 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_11 PF13086.6 ORX73103.1 - 0.023 14.5 3.5 0.86 9.3 0.0 3.9 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 ORX73103.1 - 0.024 14.4 0.1 4.7 6.9 0.0 3.4 3 1 0 3 3 3 0 DEAD/DEAH box helicase Parvo_NS1 PF01057.17 ORX73103.1 - 0.056 12.5 0.0 0.17 10.9 0.0 1.8 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 HOOK PF05622.12 ORX73103.1 - 0.089 10.9 28.1 0.34 9.0 10.8 3.4 3 0 0 3 3 3 0 HOOK protein AAA_23 PF13476.6 ORX73103.1 - 0.12 12.9 9.2 24 5.4 0.0 5.5 5 0 0 5 5 5 0 AAA domain ResIII PF04851.15 ORX73103.1 - 0.13 12.3 0.0 57 3.6 0.0 3.6 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit MobB PF03205.14 ORX73103.1 - 0.14 12.0 0.0 26 4.7 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Pox_A32 PF04665.12 ORX73103.1 - 0.15 11.5 0.1 39 3.6 0.0 3.2 3 0 0 3 3 3 0 Poxvirus A32 protein ERM PF00769.19 ORX73103.1 - 0.17 11.7 27.8 0.32 10.8 2.2 3.9 3 0 0 3 3 3 0 Ezrin/radixin/moesin family G-alpha PF00503.20 ORX73103.1 - 0.22 10.6 0.6 36 3.4 0.0 3.6 3 0 0 3 3 3 0 G-protein alpha subunit YabA PF06156.13 ORX73103.1 - 0.88 10.2 11.8 91 3.8 0.5 4.8 3 0 0 3 3 3 0 Initiation control protein YabA SRP54 PF00448.22 ORX73103.1 - 2.1 8.0 9.4 6.8 6.3 0.1 5.1 6 0 0 6 6 5 0 SRP54-type protein, GTPase domain DUF1664 PF07889.12 ORX73103.1 - 2.2 8.3 26.4 0.16 12.0 6.7 6.1 6 0 0 6 6 5 0 Protein of unknown function (DUF1664) DNA_photolyase PF00875.18 ORX73103.1 - 3.9 7.5 7.3 0.38 10.7 1.1 2.7 2 0 0 2 2 1 0 DNA photolyase KELK PF15796.5 ORX73103.1 - 9.5 6.8 14.7 6.3 7.3 0.0 3.7 3 0 0 3 3 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Arf PF00025.21 ORX73105.1 - 8.7e-55 184.9 0.0 1e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX73105.1 - 3.3e-11 42.9 0.0 4.2e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX73105.1 - 6.8e-11 42.0 0.0 8.9e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 ORX73105.1 - 2.1e-09 37.2 0.0 2.5e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX73105.1 - 5.5e-09 36.3 0.0 7.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ORX73105.1 - 6e-08 32.2 0.0 4.7e-06 26.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ORX73105.1 - 0.00019 21.5 0.0 0.00029 20.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Questin_oxidase PF14027.6 ORX73106.1 - 8e-67 226.2 0.0 9.5e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Questin oxidase-like PAS_3 PF08447.12 ORX73107.1 - 0.0055 17.0 0.0 3 8.2 0.0 3.0 2 1 1 3 3 3 2 PAS fold PAS_9 PF13426.7 ORX73107.1 - 0.073 13.3 0.0 15 5.9 0.0 2.5 2 1 0 2 2 2 0 PAS domain DUF3987 PF13148.6 ORX73108.1 - 0.17 10.8 0.2 0.23 10.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ABC_tran PF00005.27 ORX73110.1 - 2.4e-50 170.6 0.0 4e-25 88.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX73110.1 - 2.1e-38 132.6 24.1 1.3e-17 64.4 8.4 4.5 3 1 1 4 4 4 3 ABC transporter transmembrane region AAA_29 PF13555.6 ORX73110.1 - 9.4e-06 25.3 0.6 0.014 15.1 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX73110.1 - 1e-05 26.1 0.6 0.0013 19.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ORX73110.1 - 2e-05 24.2 0.1 0.0045 16.4 0.0 3.6 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX73110.1 - 2.9e-05 24.1 0.6 0.23 11.5 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 ORX73110.1 - 4.1e-05 22.8 0.4 0.15 11.1 0.2 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 ORX73110.1 - 0.00011 22.6 1.1 0.16 12.3 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX73110.1 - 0.00015 22.1 1.5 0.56 10.5 0.2 3.3 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ORX73110.1 - 0.00042 20.0 0.1 0.094 12.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX73110.1 - 0.00042 20.3 1.5 0.021 14.7 0.2 2.5 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ORX73110.1 - 0.00091 19.3 0.1 0.039 14.0 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_21 PF13304.6 ORX73110.1 - 0.0024 17.7 8.3 0.2 11.4 0.5 4.1 2 2 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 ORX73110.1 - 0.0043 16.4 0.9 1.3 8.2 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin DUF87 PF01935.17 ORX73110.1 - 0.014 15.5 4.1 1.7 8.7 0.2 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain CbiA PF01656.23 ORX73110.1 - 0.031 14.3 0.4 12 6.0 0.0 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Adeno_IVa2 PF02456.15 ORX73110.1 - 0.047 12.5 0.2 0.11 11.3 0.2 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_30 PF13604.6 ORX73110.1 - 0.053 13.2 1.4 9.2 5.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 ORX73110.1 - 0.054 14.0 0.8 7.3 7.2 0.0 3.4 4 0 0 4 4 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX73110.1 - 0.065 12.6 0.9 0.98 8.7 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ORX73110.1 - 0.19 11.4 0.1 5.8 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ORX73110.1 - 0.2 11.0 0.3 2.9 7.2 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_15 PF13175.6 ORX73110.1 - 0.26 10.9 0.1 5.4 6.6 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 ORX73110.1 - 0.84 9.2 2.5 3.2 7.3 0.4 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Y_phosphatase2 PF03162.13 ORX73113.1 - 6.3e-39 133.2 0.0 7e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX73113.1 - 0.042 13.4 0.0 0.051 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ORX73113.1 - 0.13 12.2 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family UCH PF00443.29 ORX73114.1 - 1.3e-22 80.5 0.0 2.3e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX73114.1 - 0.00026 20.7 0.0 0.21 11.1 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX73114.1 - 0.0036 17.5 0.1 0.0071 16.5 0.1 1.4 1 0 0 1 1 1 1 MATH domain PhoLip_ATPase_C PF16212.5 ORX73115.1 - 6.1e-60 203.1 28.3 6.1e-60 203.1 28.3 3.2 2 1 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX73115.1 - 9.7e-25 86.0 0.2 2.2e-24 84.9 0.2 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX73115.1 - 5.3e-10 39.3 0.0 1.4e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ORX73115.1 - 9.9e-10 38.2 0.0 3.4e-09 36.5 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX73115.1 - 2.2e-05 24.8 0.1 0.35 11.1 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Apidaecin PF00807.17 ORX73115.1 - 0.0029 17.7 0.2 0.0075 16.3 0.2 1.7 1 0 0 1 1 1 1 Apidaecin Hydrolase_3 PF08282.12 ORX73115.1 - 0.041 13.6 0.1 0.078 12.7 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PRMT5 PF05185.16 ORX73116.1 - 4.4e-63 212.2 0.0 7.6e-63 211.5 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 ORX73116.1 - 7.1e-51 172.6 0.5 1.2e-50 171.8 0.5 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 ORX73116.1 - 1.5e-32 112.8 0.0 3.2e-32 111.8 0.0 1.4 1 1 0 1 1 1 1 PRMT5 TIM barrel domain Methyltransf_25 PF13649.6 ORX73116.1 - 0.015 15.9 0.1 0.033 14.9 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 ORX73116.1 - 0.026 14.3 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein IF-2 PF11987.8 ORX73116.1 - 0.2 11.8 0.0 0.54 10.4 0.0 1.6 1 0 0 1 1 1 0 Translation-initiation factor 2 ABC_tran PF00005.27 ORX73117.1 - 8.8e-51 172.0 0.0 8.2e-28 97.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX73117.1 - 1.1e-48 166.2 27.4 1.5e-31 110.1 11.2 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 ORX73117.1 - 2.9e-10 39.9 1.5 0.00097 18.6 0.1 3.7 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ORX73117.1 - 3e-07 29.8 0.1 0.011 14.8 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 ORX73117.1 - 5.9e-07 29.1 0.6 0.0066 16.2 0.1 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX73117.1 - 1.7e-05 25.3 0.1 0.071 13.5 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ORX73117.1 - 1.7e-05 25.4 0.6 0.0019 18.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ORX73117.1 - 2.8e-05 24.2 0.7 0.25 11.4 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX73117.1 - 0.00021 21.2 0.1 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ORX73117.1 - 0.0016 18.5 0.1 0.076 13.1 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_25 PF13481.6 ORX73117.1 - 0.0016 18.0 0.7 0.33 10.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ORX73117.1 - 0.0017 18.7 4.6 2.6 8.3 0.6 3.5 2 1 0 2 2 2 2 AAA domain AAA_21 PF13304.6 ORX73117.1 - 0.0021 17.9 7.9 0.46 10.2 0.7 4.1 2 2 2 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ORX73117.1 - 0.0028 17.2 0.0 0.18 11.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX73117.1 - 0.0031 16.8 0.8 1.1 8.5 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin DUF87 PF01935.17 ORX73117.1 - 0.0074 16.4 3.7 1.2 9.1 0.2 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain Adeno_IVa2 PF02456.15 ORX73117.1 - 0.018 13.9 0.1 0.06 12.1 0.0 1.7 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_18 PF13238.6 ORX73117.1 - 0.021 15.4 0.3 4.4 7.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX73117.1 - 0.023 14.1 0.5 0.68 9.2 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 ORX73117.1 - 0.037 13.7 1.3 12 5.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 ORX73117.1 - 0.077 13.0 0.3 14 5.7 0.0 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_M50 PF02163.22 ORX73117.1 - 0.11 11.8 0.3 0.35 10.1 0.0 2.0 3 0 0 3 3 3 0 Peptidase family M50 MeaB PF03308.16 ORX73117.1 - 0.16 10.9 0.3 4.6 6.2 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 ORX73117.1 - 0.23 11.1 0.1 6.1 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 ORX73117.1 - 0.66 8.8 2.5 3.8 6.3 0.2 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 ORX73117.1 - 1.3 8.6 3.0 3.6 7.2 0.5 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PIG-U PF06728.13 ORX73118.1 - 3.7e-96 322.5 23.1 4.3e-96 322.3 23.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 ORX73118.1 - 0.041 13.6 10.3 0.1 12.3 8.5 2.2 1 1 1 2 2 2 0 8TM Microsporidial transmembrane domain DUF3810 PF12725.7 ORX73118.1 - 0.24 10.7 2.3 0.41 9.9 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) NDT80_PhoG PF05224.12 ORX73119.1 - 9e-35 120.6 0.2 4.4e-34 118.3 0.0 2.3 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family COG7 PF10191.9 ORX73120.1 - 5.7e-06 24.9 6.5 6e-05 21.5 3.2 2.4 2 1 0 2 2 2 2 Golgi complex component 7 (COG7) DUF1993 PF09351.10 ORX73120.1 - 0.041 14.0 1.0 2.4 8.3 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) Exo70 PF03081.15 ORX73120.1 - 0.047 12.8 0.0 0.12 11.4 0.0 1.7 1 0 0 1 1 1 0 Exo70 exocyst complex subunit Phage_GPO PF05929.11 ORX73120.1 - 2.3 7.8 5.6 1.4 8.5 3.3 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase UQ_con PF00179.26 ORX73121.1 - 4.6e-49 165.7 0.0 5.2e-49 165.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX73121.1 - 6.3e-05 22.7 0.0 8.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ORX73121.1 - 0.0097 15.8 0.1 0.019 14.8 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 ORX73121.1 - 0.056 13.7 0.1 0.088 13.1 0.1 1.4 1 1 0 1 1 1 0 RWD domain zf-RING_2 PF13639.6 ORX73124.1 - 8.1e-10 38.9 12.9 8.1e-10 38.9 12.9 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ORX73124.1 - 1.1e-08 34.6 8.0 3.2e-08 33.2 8.0 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX73124.1 - 3.5e-06 26.8 13.0 3.5e-06 26.8 13.0 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX73124.1 - 1.2e-05 25.5 12.9 1.2e-05 25.5 12.9 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX73124.1 - 9.8e-05 22.2 12.5 9.8e-05 22.2 12.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX73124.1 - 0.00023 21.1 11.3 0.00023 21.1 11.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX73124.1 - 0.0016 18.5 10.0 0.0029 17.6 10.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ORX73124.1 - 0.0026 17.6 9.5 0.0026 17.6 9.5 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ORX73124.1 - 0.0029 17.6 10.8 0.0085 16.1 10.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX73124.1 - 0.031 14.1 16.5 0.031 14.1 16.5 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX73124.1 - 0.11 12.7 9.4 0.34 11.1 9.4 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Clostridium_P47 PF06597.11 ORX73124.1 - 0.23 10.2 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 Clostridium P-47 protein Zn_ribbon_17 PF17120.5 ORX73124.1 - 1.4 8.6 14.3 3 7.6 14.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type p450 PF00067.22 ORX73125.1 - 8.3e-77 258.9 0.0 1e-76 258.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PAP2 PF01569.21 ORX73127.1 - 1.5e-32 112.2 0.2 1.5e-32 112.2 0.2 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ORX73127.1 - 0.083 12.6 14.3 0.0097 15.6 7.8 2.5 2 1 0 2 2 2 0 PAP2 superfamily YesK PF14150.6 ORX73127.1 - 0.27 11.5 3.2 0.61 10.3 0.6 2.3 2 0 0 2 2 2 0 YesK-like protein DUF3169 PF11368.8 ORX73127.1 - 0.31 10.5 1.3 0.42 10.1 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) ABC_tran PF00005.27 ORX73128.1 - 3.2e-07 30.9 0.0 5.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX73128.1 - 0.00086 18.8 0.1 0.0011 18.5 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain FKBP_N_2 PF18023.1 ORX73128.1 - 0.017 15.2 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 BDBT FKBP like N-terminal SbcCD_C PF13558.6 ORX73128.1 - 0.099 12.9 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 ORX73129.1 - 4.6e-15 56.3 0.0 1.1e-14 55.2 0.0 1.5 1 1 0 1 1 1 1 ABC transporter cobW PF02492.19 ORX73129.1 - 0.12 11.9 0.4 0.23 11.0 0.4 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 ORX73129.1 - 0.16 11.7 1.2 2.3 7.9 0.0 2.0 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Cation_efflux PF01545.21 ORX73131.1 - 9.3e-54 182.2 7.6 1.2e-53 181.8 7.6 1.1 1 0 0 1 1 1 1 Cation efflux family V_ATPase_I PF01496.19 ORX73131.1 - 0.026 12.5 0.0 0.026 12.5 0.0 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Zip PF02535.22 ORX73131.1 - 0.094 11.9 33.9 0.012 14.8 17.3 2.6 1 1 1 2 2 2 0 ZIP Zinc transporter SMAP PF15477.6 ORX73132.1 - 3.7e-12 47.0 2.9 3.7e-12 47.0 2.9 3.2 2 1 0 2 2 1 1 Small acidic protein family Presenilin PF01080.17 ORX73132.1 - 0.074 11.8 15.1 0.068 11.9 15.1 1.1 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 ORX73132.1 - 0.13 11.6 36.0 0.13 11.6 36.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SET PF00856.28 ORX73132.1 - 0.21 12.0 5.3 0.25 11.7 5.3 1.3 1 0 0 1 1 1 0 SET domain DUF2151 PF10221.9 ORX73132.1 - 0.25 9.9 16.0 0.24 9.9 16.0 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF2052 PF09747.9 ORX73132.1 - 0.32 11.1 22.6 0.42 10.7 22.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SpoIIP PF07454.11 ORX73132.1 - 0.34 10.3 18.1 0.49 9.8 18.1 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 ORX73132.1 - 0.36 11.0 11.6 0.4 10.8 11.6 1.2 1 0 0 1 1 1 0 DDHD domain ASC PF00858.24 ORX73132.1 - 0.57 9.1 5.0 0.53 9.2 5.0 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Zip PF02535.22 ORX73132.1 - 0.58 9.3 14.2 0.6 9.3 14.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ORX73132.1 - 0.7 10.2 39.2 1 9.6 39.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SOBP PF15279.6 ORX73132.1 - 0.71 10.4 9.3 0.75 10.4 9.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Neur_chan_memb PF02932.16 ORX73132.1 - 0.75 9.8 12.1 0.82 9.7 12.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5427 PF10310.9 ORX73132.1 - 0.92 8.4 27.6 1.2 8.0 27.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Otopetrin PF03189.13 ORX73132.1 - 1.1 8.0 4.0 1.1 8.0 4.0 1.1 1 0 0 1 1 1 0 Otopetrin MDM10 PF12519.8 ORX73132.1 - 1.9 7.2 14.6 1.9 7.3 14.6 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Mitofilin PF09731.9 ORX73132.1 - 2.2 7.0 26.8 2.2 7.0 26.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein RR_TM4-6 PF06459.12 ORX73132.1 - 2.4 7.9 31.2 3.5 7.4 31.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RPOL_N PF14700.6 ORX73132.1 - 3.1 7.1 23.4 4.4 6.6 23.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal CENP-N PF05238.13 ORX73132.1 - 3.8 6.7 14.8 4.7 6.4 14.8 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like ALMT PF11744.8 ORX73132.1 - 5 5.8 16.7 5.4 5.7 16.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 ORX73132.1 - 5.3 6.3 19.2 7.5 5.9 19.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDRGK PF09756.9 ORX73132.1 - 5.8 6.5 37.7 7.7 6.1 37.7 1.2 1 0 0 1 1 1 0 DDRGK domain AF-4 PF05110.13 ORX73132.1 - 5.8 4.9 30.0 5.9 4.8 30.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein NPR3 PF03666.13 ORX73132.1 - 6.2 5.5 24.4 7.2 5.3 24.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GREB1 PF15782.5 ORX73132.1 - 9.3 3.2 10.8 9.7 3.1 10.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Myosin_head PF00063.21 ORX73133.1 - 6.3e-70 236.2 0.0 1.7e-69 234.7 0.0 1.8 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 ORX73133.1 - 5.2e-12 44.5 290.5 7.1e-06 24.2 57.5 5.1 1 1 3 4 4 4 4 Myosin tail Sfi1_C PF10638.9 ORX73133.1 - 0.13 13.0 5.4 0.29 11.9 0.8 4.2 2 0 0 2 2 2 0 Spindle body associated protein C-terminus SPC12 PF06645.13 ORX73134.1 - 2.3e-22 78.9 3.0 2.5e-22 78.7 3.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) MTHFR PF02219.17 ORX73135.1 - 7.1e-112 373.4 0.0 9.5e-112 373.0 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase tRNA-synt_1c PF00749.21 ORX73137.1 - 1.1e-93 313.6 0.0 1.3e-93 313.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain UPF0203 PF05254.12 ORX73138.1 - 0.061 13.6 0.4 0.087 13.1 0.2 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) CX9C PF16860.5 ORX73138.1 - 0.086 12.9 1.5 0.24 11.4 0.4 2.0 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Methyltransf_25 PF13649.6 ORX73139.1 - 8.7e-14 52.0 0.1 2.1e-13 50.8 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX73139.1 - 3.5e-12 46.8 0.2 9.7e-12 45.4 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX73139.1 - 3.7e-12 46.3 0.0 8.4e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX73139.1 - 6.6e-11 42.1 0.1 6.6e-11 42.1 0.1 1.6 2 0 0 2 2 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX73139.1 - 1.3e-06 28.1 0.1 2.7e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ORX73139.1 - 8.6e-06 26.4 0.0 1.8e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX73139.1 - 1e-05 25.5 0.0 2.3e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX73139.1 - 1.4e-05 25.1 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2_2 PF12756.7 ORX73139.1 - 5.9e-05 23.3 0.3 0.00014 22.1 0.3 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) PCMT PF01135.19 ORX73139.1 - 0.0001 22.1 0.1 0.00018 21.4 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ORX73139.1 - 0.0001 21.7 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 ORX73139.1 - 0.00032 19.7 0.0 0.00055 19.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 ORX73139.1 - 0.0025 17.2 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 ORX73139.1 - 0.0032 16.9 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 ORX73139.1 - 0.0034 17.1 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 FtsJ PF01728.19 ORX73139.1 - 0.0043 17.2 0.0 0.0093 16.1 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 ORX73139.1 - 0.0075 16.0 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_24 PF13578.6 ORX73139.1 - 0.0075 17.3 0.0 0.026 15.5 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain UPF0020 PF01170.18 ORX73139.1 - 0.0081 15.9 0.3 0.019 14.7 0.2 1.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 PRMT5 PF05185.16 ORX73139.1 - 0.021 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 ORX73139.1 - 0.023 14.5 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_2 PF00891.18 ORX73139.1 - 0.026 13.8 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain zf-C2H2_11 PF16622.5 ORX73139.1 - 0.048 13.4 0.5 0.093 12.5 0.5 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type Methyltransf_32 PF13679.6 ORX73139.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain zf-C2H2_4 PF13894.6 ORX73139.1 - 0.2 12.6 1.0 0.52 11.3 1.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Bac_DnaA PF00308.18 ORX73141.1 - 0.072 12.9 0.0 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Bacterial dnaA protein Trypsin PF00089.26 ORX73142.1 - 0.00011 22.1 0.3 0.0022 17.9 0.0 2.3 2 0 0 2 2 2 1 Trypsin SKG6 PF08693.10 ORX73142.1 - 0.002 17.5 0.1 0.0043 16.4 0.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Comm PF15957.5 ORX73142.1 - 0.0065 16.8 0.0 0.022 15.1 0.0 1.9 2 0 0 2 2 2 1 Commissureless TMEM154 PF15102.6 ORX73142.1 - 0.046 13.6 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family tRNA_int_end_N2 PF12928.7 ORX73143.1 - 2e-06 27.9 0.1 6.4e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 ORX73143.1 - 0.02 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain HSF_DNA-bind PF00447.17 ORX73144.1 - 6e-30 103.7 3.4 9.3e-30 103.1 3.4 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding TRF PF08558.10 ORX73144.1 - 0.0042 16.7 0.3 0.0075 15.9 0.3 1.4 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) JIP_LZII PF16471.5 ORX73144.1 - 0.28 11.4 3.3 0.58 10.4 1.4 2.0 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II NDUF_B12 PF08122.12 ORX73145.1 - 2.2e-22 78.8 0.2 2.4e-22 78.7 0.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family 2-oxoacid_dh PF00198.23 ORX73146.1 - 4.5e-72 242.3 0.0 5.8e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX73146.1 - 2e-17 62.8 0.3 4.8e-17 61.6 0.1 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 ORX73146.1 - 5.2e-16 58.7 0.1 1.5e-15 57.2 0.1 1.9 1 0 0 1 1 1 1 e3 binding domain Methyltransf_28 PF02636.17 ORX73147.1 - 1e-33 117.1 0.0 1.4e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 ORX73147.1 - 0.076 13.8 0.0 0.14 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1639 PF07797.14 ORX73147.1 - 0.75 9.8 2.8 1.6 8.7 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) GCS PF03074.16 ORX73148.1 - 5.1e-99 332.1 0.0 7.5e-99 331.5 0.0 1.2 1 1 0 1 1 1 1 Glutamate-cysteine ligase ABC_tran PF00005.27 ORX73149.1 - 4.4e-41 140.6 0.0 1.5e-29 103.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ORX73149.1 - 1.4e-30 106.9 15.4 1.8e-30 106.5 15.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX73149.1 - 1.5e-07 31.0 2.9 0.00041 19.8 0.1 3.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX73149.1 - 0.017 15.2 0.1 0.043 13.9 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX73149.1 - 0.028 14.2 1.4 3.5 7.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system GPR_Gpa2_C PF11970.8 ORX73149.1 - 0.033 14.2 0.3 0.11 12.5 0.3 1.9 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF87 PF01935.17 ORX73149.1 - 0.18 11.9 0.1 0.37 10.9 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Pkinase PF00069.25 ORX73150.1 - 1.3e-67 227.9 0.0 1.6e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73150.1 - 3e-36 125.0 0.0 3.8e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ORX73150.1 - 2.2e-15 56.8 0.2 5e-15 55.6 0.2 1.6 1 0 0 1 1 1 1 FHA domain Kdo PF06293.14 ORX73150.1 - 1.1e-06 28.2 0.0 2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX73150.1 - 2.5e-06 27.0 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 ORX73150.1 - 2.1e-05 24.7 0.0 4.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Haspin_kinase PF12330.8 ORX73150.1 - 4.8e-05 22.5 0.0 0.00011 21.4 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX73150.1 - 0.0019 18.2 0.0 0.7 9.8 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX73150.1 - 0.027 13.2 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase EcKinase PF02958.20 ORX73150.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase MaoC_dehydratas PF01575.19 ORX73152.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 MaoC like domain Proteasome PF00227.26 ORX73153.1 - 9.5e-24 83.9 0.0 6.9e-08 32.2 0.0 3.0 1 1 2 3 3 3 3 Proteasome subunit 2Fe-2S_thioredx PF01257.19 ORX73154.1 - 1.3e-34 119.1 0.1 1.9e-34 118.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PHO4 PF01384.20 ORX73155.1 - 5.4e-119 397.2 18.2 6.3e-119 397.0 18.2 1.0 1 0 0 1 1 1 1 Phosphate transporter family Ykof PF07615.11 ORX73155.1 - 0.1 13.1 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 YKOF-related Family Rax2 PF12768.7 ORX73155.1 - 0.16 11.4 0.2 0.3 10.5 0.2 1.4 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Redoxin PF08534.10 ORX73156.1 - 7.6e-37 126.3 0.0 8.7e-37 126.1 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ORX73156.1 - 4.9e-10 39.4 0.0 5.5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family NAC PF01849.18 ORX73157.1 - 5.6e-17 61.5 0.1 9.2e-17 60.8 0.1 1.4 1 0 0 1 1 1 1 NAC domain SMC_N PF02463.19 ORX73158.1 - 3.6e-54 183.5 0.0 3.6e-49 167.2 0.0 2.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX73158.1 - 1.1e-19 70.8 0.1 4.9e-19 68.8 0.1 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX73158.1 - 7.3e-16 58.8 0.0 2.2e-08 34.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX73158.1 - 1e-10 42.4 0.2 1e-10 42.4 0.2 4.9 2 1 1 4 4 2 1 AAA domain AAA_15 PF13175.6 ORX73158.1 - 2.2e-07 30.9 0.1 6.7e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ORX73158.1 - 2.2e-05 24.1 0.0 6.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain TPR_MLP1_2 PF07926.12 ORX73158.1 - 0.0044 17.1 3.7 0.0044 17.1 3.7 6.9 5 3 1 6 6 6 2 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 ORX73158.1 - 0.0084 16.1 32.5 0.097 12.7 0.4 7.1 7 1 1 8 8 8 3 Protein of unknown function (DUF1664) ABC_tran PF00005.27 ORX73158.1 - 0.031 14.8 15.8 51 4.4 0.0 4.8 2 2 0 2 2 2 0 ABC transporter Sec34 PF04136.15 ORX73158.1 - 0.78 9.6 16.7 6.1 6.7 0.1 5.8 5 1 1 6 6 6 0 Sec34-like family AAA_22 PF13401.6 ORX73158.1 - 4.6 7.5 9.9 19 5.5 0.0 4.9 4 2 1 5 5 5 0 AAA domain AurF PF11583.8 ORX73160.1 - 0.0088 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 P-aminobenzoate N-oxygenase AurF DUF4112 PF13430.6 ORX73161.1 - 1.5e-34 118.4 0.1 1.9e-34 118.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF411 PF04214.13 ORX73161.1 - 0.2 11.6 0.0 0.64 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF HSCB_C PF07743.13 ORX73162.1 - 1.7e-18 66.9 7.0 3.6e-18 65.8 4.8 2.0 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ORX73162.1 - 0.0016 18.6 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DNA_Packaging PF11053.8 ORX73162.1 - 0.071 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Terminase DNA packaging enzyme DUF2508 PF10704.9 ORX73162.1 - 0.12 12.6 2.2 0.18 12.0 0.4 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) zinc_ribbon_2 PF13240.6 ORX73162.1 - 0.65 9.8 2.4 0.7 9.7 0.4 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Sugar_tr PF00083.24 ORX73163.1 - 2.8e-79 267.1 14.4 8.1e-79 265.6 14.4 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX73163.1 - 2.5e-22 79.3 28.6 2.5e-22 79.3 28.6 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3165 PF11364.8 ORX73163.1 - 0.01 16.1 1.7 0.045 14.1 1.7 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3165) BK_channel_a PF03493.18 ORX73164.1 - 0.032 14.4 0.1 0.044 14.0 0.1 1.2 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Rad21_Rec8_N PF04825.13 ORX73165.1 - 1.6e-33 115.1 0.0 3e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ORX73165.1 - 1.8e-14 52.8 0.1 3.3e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 ORX73165.1 - 0.028 14.3 0.0 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 Segregation and condensation protein ScpA Neugrin PF06413.11 ORX73166.1 - 1.2e-17 64.7 0.9 1.2e-17 64.7 0.9 2.0 2 0 0 2 2 2 1 Neugrin MRP-L20 PF12824.7 ORX73166.1 - 5.6e-07 29.9 2.8 5.6e-07 29.9 2.8 1.6 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 HTH_11 PF08279.12 ORX73166.1 - 0.018 14.9 0.3 0.05 13.5 0.0 1.9 2 0 0 2 2 2 0 HTH domain Sigma70_r4 PF04545.16 ORX73166.1 - 0.025 14.1 0.9 0.051 13.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 ORX73166.1 - 0.036 13.9 0.9 0.085 12.7 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_31 PF13560.6 ORX73166.1 - 0.14 12.5 2.5 0.15 12.4 0.4 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain SCP2 PF02036.17 ORX73169.1 - 7.1e-42 142.0 6.0 9.7e-22 77.4 1.1 2.2 2 0 0 2 2 2 2 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ORX73169.1 - 2.1e-11 44.2 2.1 6.2e-05 23.3 0.3 2.3 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal LPD26 PF18842.1 ORX73169.1 - 0.054 13.5 0.9 0.12 12.3 0.9 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 Thymosin PF01290.20 ORX73170.1 - 0.071 12.8 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Thymosin beta-4 family Cytochrom_C PF00034.21 ORX73175.1 - 6.2e-07 30.5 0.0 8.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ORX73175.1 - 2.8e-05 24.3 0.0 4.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ORX73175.1 - 0.043 13.5 0.2 0.099 12.3 0.1 1.8 1 1 0 1 1 1 0 Cytochrome c-550 domain FR47 PF08445.10 ORX73176.1 - 0.00042 20.2 0.0 0.018 15.0 0.0 2.7 3 0 0 3 3 3 1 FR47-like protein Acetyltransf_7 PF13508.7 ORX73176.1 - 0.0029 18.0 0.0 0.004 17.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX73176.1 - 0.0065 16.7 0.0 0.0094 16.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX73176.1 - 0.016 15.2 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 ORX73176.1 - 0.096 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RrnaAD PF00398.20 ORX73177.1 - 1e-61 208.4 0.0 1.4e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ORX73177.1 - 4.3e-06 27.3 0.0 9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX73177.1 - 0.00062 20.4 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX73177.1 - 0.002 17.7 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ORX73177.1 - 0.0069 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ORX73177.1 - 0.023 14.0 0.1 0.084 12.2 0.0 1.8 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ORX73177.1 - 0.065 12.6 0.1 0.12 11.7 0.0 1.4 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ORX73177.1 - 0.074 12.9 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 ORX73177.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_12 PF08242.12 ORX73177.1 - 0.17 12.7 0.0 0.33 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Clat_adaptor_s PF01217.20 ORX73178.1 - 1.2e-20 73.9 0.1 1.9e-20 73.2 0.1 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.6 ORX73178.1 - 0.0018 18.3 0.0 0.0033 17.5 0.0 1.4 1 1 0 1 1 1 1 AP-5 complex subunit sigma-1 Beach PF02138.18 ORX73181.1 - 1e-59 202.2 0.0 1.1e-59 202.1 0.0 1.0 1 0 0 1 1 1 1 Beige/BEACH domain Peptidase_M16 PF00675.20 ORX73183.1 - 1.3e-07 31.7 0.0 1.9e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX73183.1 - 0.0034 17.4 0.0 0.0059 16.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain ABC_membrane PF00664.23 ORX73185.1 - 9.7e-07 28.7 3.1 4e-06 26.7 0.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX73186.1 - 2.8e-05 24.6 0.0 4.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX73186.1 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX73186.1 - 0.0028 17.7 0.0 0.005 16.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX73186.1 - 0.0038 16.9 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX73186.1 - 0.0056 16.5 0.0 0.0073 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 ORX73186.1 - 0.01 15.9 0.1 0.021 14.9 0.1 1.5 1 0 0 1 1 1 0 Dynamin family cobW PF02492.19 ORX73186.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ORX73186.1 - 0.024 14.5 0.1 0.043 13.7 0.1 1.3 1 1 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 ORX73186.1 - 0.057 13.3 0.0 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 ORX73186.1 - 0.069 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain KH_2 PF07650.17 ORX73186.1 - 0.1 12.4 0.0 4.1 7.3 0.0 2.1 2 0 0 2 2 2 0 KH domain AAA_30 PF13604.6 ORX73186.1 - 0.11 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX73186.1 - 0.13 12.8 0.2 0.25 11.8 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX73186.1 - 0.17 12.1 0.0 0.77 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX73186.1 - 0.17 12.2 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ORX73187.1 - 1.2e-30 106.8 0.0 2.4e-30 105.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX73187.1 - 1.2e-06 28.1 0.0 0.00078 18.9 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ORX73187.1 - 0.0017 17.4 0.3 0.004 16.3 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 ORX73187.1 - 0.0033 17.5 0.2 0.008 16.3 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 ORX73187.1 - 0.0072 16.4 0.3 0.027 14.6 0.1 1.9 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_21 PF13304.6 ORX73187.1 - 0.017 14.9 0.1 0.038 13.8 0.0 1.5 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 ORX73187.1 - 0.017 14.1 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 ORX73187.1 - 0.05 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ORX73187.1 - 0.051 13.3 0.1 0.33 10.6 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 ORX73187.1 - 0.1 13.0 0.1 0.19 12.1 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 ORX73187.1 - 0.14 11.3 2.6 6.2 5.9 0.9 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 ORX73187.1 - 0.21 11.6 1.4 22 5.0 0.2 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ORX73188.1 - 3.3e-14 53.6 0.0 1e-05 26.0 0.0 3.8 2 2 1 3 3 3 2 ABC transporter ABC_membrane PF00664.23 ORX73188.1 - 1.4e-07 31.5 3.8 1.2e-06 28.4 3.8 2.4 1 1 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX73188.1 - 0.0044 16.5 0.0 0.0079 15.7 0.0 1.5 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Tfb5 PF06331.12 ORX73189.1 - 1.2e-23 82.9 0.4 1.3e-23 82.7 0.4 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 BCDHK_Adom3 PF10436.9 ORX73190.1 - 9.4e-36 123.1 0.0 1.4e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX73190.1 - 2.1e-09 37.9 0.0 1.1e-08 35.6 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX73190.1 - 5.4e-05 23.0 0.0 8.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3395 PF11875.8 ORX73191.1 - 1.8e-34 118.9 0.5 6e-34 117.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 ORX73191.1 - 2.7e-18 65.8 0.8 5.2e-18 64.9 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain Aminotran_5 PF00266.19 ORX73192.1 - 1.8e-13 50.2 0.0 2.5e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ORX73192.1 - 0.0038 16.5 0.0 0.14 11.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ORX73192.1 - 0.091 12.1 0.1 0.12 11.6 0.1 1.3 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family RNase_P_p30 PF01876.16 ORX73193.1 - 1.2e-45 155.6 0.0 1.5e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 RNA_pol_Rpb4 PF03874.16 ORX73194.1 - 4.3e-22 78.7 0.8 4.3e-22 78.7 0.8 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb4 TFIIA PF03153.13 ORX73194.1 - 0.69 9.8 7.3 0.76 9.7 7.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYDLN_acid PF09538.10 ORX73194.1 - 2.5 8.8 15.3 0.76 10.5 12.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 ORX73194.1 - 9 4.3 21.9 12 3.8 21.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi ATP_synt_H PF05493.13 ORX73195.1 - 4.1e-18 65.6 1.4 4.8e-18 65.4 1.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF3768 PF12599.8 ORX73195.1 - 0.18 11.9 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3768) DUF4131 PF13567.6 ORX73195.1 - 0.36 10.5 3.5 0.4 10.3 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) HAUS-augmin3 PF14932.6 ORX73196.1 - 0.00023 20.9 2.9 0.00066 19.3 2.9 1.7 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF812 PF05667.11 ORX73196.1 - 0.019 13.9 0.6 0.04 12.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) APH PF01636.23 ORX73197.1 - 8e-13 48.9 0.0 2.8e-05 24.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 ORX73197.1 - 3.1e-12 46.4 0.1 4.9e-12 45.8 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 ORX73197.1 - 6e-12 45.4 0.1 1.1e-11 44.5 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX73197.1 - 4.1e-11 42.8 0.0 5.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 ORX73197.1 - 6e-07 29.0 0.0 2.1e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase WaaY PF06176.11 ORX73197.1 - 0.00015 21.5 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.20 ORX73197.1 - 0.0032 17.1 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 ORX73197.1 - 0.014 14.7 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase Seadorna_VP7 PF07387.11 ORX73197.1 - 0.033 13.3 0.1 0.049 12.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Fructosamin_kin PF03881.14 ORX73197.1 - 0.15 11.2 0.1 1.4 8.1 0.1 2.0 1 1 1 2 2 2 0 Fructosamine kinase DDOST_48kD PF03345.14 ORX73198.1 - 2.7e-116 388.8 0.4 4.7e-116 388.1 0.4 1.3 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta EMC1_C PF07774.13 ORX73199.1 - 7.9e-37 127.0 0.0 8.6e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal LTV PF04180.14 ORX73200.1 - 1.3e-56 193.0 34.7 5.9e-53 181.0 21.8 3.2 1 1 1 2 2 2 2 Low temperature viability protein LCAT PF02450.15 ORX73203.1 - 6.1e-06 25.6 0.0 0.08 12.1 0.0 2.2 2 0 0 2 2 2 2 Lecithin:cholesterol acyltransferase DUF2752 PF10825.8 ORX73203.1 - 0.0016 18.4 0.0 0.19 11.8 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2752) PAG PF15347.6 ORX73203.1 - 0.045 12.8 5.4 0.065 12.2 5.4 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Nitrophorin PF02087.15 ORX73203.1 - 0.054 13.5 0.2 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Nitrophorin CBM_5_12_2 PF14600.6 ORX73203.1 - 0.095 12.6 0.0 25 4.9 0.0 2.6 2 0 0 2 2 2 0 Cellulose-binding domain DUF818 PF05677.12 ORX73203.1 - 0.11 11.4 0.0 12 4.7 0.0 2.1 2 0 0 2 2 2 0 Chlamydia CHLPS protein (DUF818) PBP PF01161.20 ORX73204.1 - 6.7e-13 49.1 0.1 7.4e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Neurochondrin PF05536.11 ORX73205.1 - 3.8e-36 124.6 0.1 4.6e-36 124.4 0.1 1.0 1 0 0 1 1 1 1 Neurochondrin Nucleos_tra2_C PF07662.13 ORX73207.1 - 3.9e-70 235.9 5.4 3.9e-70 235.9 5.4 2.8 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ORX73207.1 - 6.1e-20 71.6 1.0 6.1e-20 71.6 1.0 3.3 4 1 1 5 5 5 1 Na+ dependent nucleoside transporter N-terminus PQ-loop PF04193.14 ORX73208.1 - 5.6e-32 109.3 17.1 1.7e-21 75.7 0.8 3.5 4 0 0 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 ORX73208.1 - 0.13 13.1 5.6 0.91 10.3 0.1 2.7 1 1 1 2 2 2 0 ER lumen protein retaining receptor Ribosomal_L33 PF00471.20 ORX73209.1 - 3.7e-10 40.1 0.0 5.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L33 Pkinase PF00069.25 ORX73210.1 - 7.7e-71 238.5 0.0 9.3e-71 238.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73210.1 - 2.7e-36 125.2 0.0 3.5e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX73210.1 - 1.9e-08 34.0 0.0 6.4e-08 32.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 ORX73210.1 - 1.7e-05 25.4 6.9 2.9e-05 24.7 4.1 2.7 3 1 0 3 3 3 1 Protein kinase C terminal domain FTA2 PF13095.6 ORX73210.1 - 0.0086 15.7 0.0 3.7 7.1 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 ATG7_N PF16420.5 ORX73211.1 - 9e-41 140.5 0.0 7.3e-30 104.6 0.0 4.0 2 1 1 3 3 3 2 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ORX73211.1 - 1.3e-28 100.1 0.0 6.3e-28 97.8 0.0 1.9 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ORX73211.1 - 0.0023 18.0 0.1 0.021 14.9 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase RPN1_RPN2_N PF17781.1 ORX73212.1 - 1e-97 327.3 1.5 3e-97 325.8 1.4 1.9 2 1 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 ORX73212.1 - 1.7e-30 104.8 0.1 3.7e-30 103.7 0.1 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 ORX73212.1 - 3.6e-25 87.1 21.9 3.6e-05 24.0 0.3 8.9 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ORX73212.1 - 1e-06 29.0 4.4 0.0099 16.3 0.4 5.1 4 2 1 5 5 5 3 HEAT repeats DUF4456 PF14644.6 ORX73212.1 - 0.03 14.0 0.4 0.07 12.8 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) COG5 PF10392.9 ORX73212.1 - 0.095 12.9 1.9 0.35 11.1 1.9 2.0 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DsbD_2 PF13386.6 ORX73212.1 - 0.14 12.1 1.1 0.36 10.8 1.1 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region PAS_3 PF08447.12 ORX73213.1 - 0.0056 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ORX73213.1 - 0.025 14.8 0.0 0.077 13.3 0.0 2.0 1 1 1 2 2 2 0 PAS domain PAS_4 PF08448.10 ORX73213.1 - 0.054 13.8 0.0 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 PAS fold DPRP PF04244.13 ORX73214.1 - 0.029 14.3 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein DUF1241 PF06840.11 ORX73214.1 - 0.057 13.1 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) ELFV_dehydrog PF00208.21 ORX73215.1 - 9.6e-58 195.8 0.0 1.4e-57 195.2 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ORX73215.1 - 8e-22 76.7 0.0 7.8e-14 50.2 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase MRP-L20 PF12824.7 ORX73216.1 - 1.7e-18 67.4 0.9 1.8e-18 67.3 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 ORX73216.1 - 0.0046 17.0 0.1 0.0064 16.5 0.1 1.3 1 0 0 1 1 1 1 Neugrin Pribosyltran_N PF13793.6 ORX73217.1 - 1.1e-35 122.0 0.9 8.7e-35 119.2 0.1 2.3 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ORX73217.1 - 9.5e-30 104.0 1.9 1.9e-22 80.2 1.0 3.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ORX73217.1 - 9.8e-09 34.9 0.0 2.3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CS PF04969.16 ORX73218.1 - 6.8e-11 43.0 0.0 1.5e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 CS domain UBA_4 PF14555.6 ORX73218.1 - 0.027 14.3 0.3 0.089 12.6 0.1 2.0 2 0 0 2 2 2 0 UBA-like domain CHMI PF02962.15 ORX73218.1 - 0.04 14.2 0.0 0.091 13.1 0.0 1.5 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase Sulfate_transp PF00916.20 ORX73219.1 - 8.7e-44 149.8 14.7 8.7e-44 149.8 14.7 1.9 1 1 1 2 2 2 1 Sulfate permease family STAS PF01740.21 ORX73219.1 - 7.8e-06 25.5 0.1 1.6e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 STAS domain Transferase PF02458.15 ORX73220.1 - 3.2e-11 42.5 0.0 6.3e-09 35.0 0.0 2.7 2 1 0 2 2 2 2 Transferase family DUF1729 PF08354.10 ORX73222.1 - 6e-127 423.4 0.0 1e-126 422.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX73222.1 - 2.5e-53 181.6 2.0 3.8e-53 181.1 0.0 2.4 4 0 0 4 4 4 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX73222.1 - 9.8e-50 169.1 0.1 2.9e-49 167.5 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX73222.1 - 1.5e-43 148.9 0.8 3.2e-43 147.7 0.8 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX73222.1 - 1.2e-21 76.5 0.0 6.5e-21 74.2 0.0 2.2 2 0 0 2 2 2 1 MaoC like domain FAS_meander PF17951.1 ORX73222.1 - 1.6e-20 73.4 0.0 3.9e-20 72.2 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX73222.1 - 8.5e-20 71.5 0.0 1.7e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 ORX73222.1 - 1.2e-18 67.7 0.0 3e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX73222.1 - 4.2e-15 55.8 0.0 1e-14 54.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX73222.1 - 0.0031 17.6 0.2 0.013 15.6 0.1 2.1 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX73222.1 - 0.0038 17.2 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta dUTPase PF00692.19 ORX73223.1 - 2.7e-29 101.5 0.0 3.5e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 dUTPase Carmo_coat_C PF08462.10 ORX73223.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Carmovirus coat protein Retrotrans_gag PF03732.17 ORX73224.1 - 0.0033 17.7 0.1 0.0085 16.3 0.1 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein 5_nucleotid PF05761.14 ORX73224.1 - 0.075 11.9 0.1 0.3 9.9 0.0 1.8 2 0 0 2 2 2 0 5' nucleotidase family zf-CCHC PF00098.23 ORX73224.1 - 0.16 12.1 1.6 0.26 11.5 1.6 1.3 1 0 0 1 1 1 0 Zinc knuckle Phosducin PF02114.16 ORX73225.1 - 1.1e-11 44.1 0.1 3.3e-11 42.6 0.1 1.7 1 1 0 1 1 1 1 Phosducin Eno-Rase_FAD_bd PF07055.12 ORX73225.1 - 0.029 14.8 0.3 0.56 10.7 0.0 2.8 2 1 0 3 3 3 0 Enoyl reductase FAD binding domain TC1 PF15063.6 ORX73225.1 - 0.044 13.6 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Thyroid cancer protein 1 DUF4129 PF13559.6 ORX73225.1 - 0.1 12.9 2.4 0.14 12.5 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) Gp_dh_C PF02800.20 ORX73226.1 - 1.3e-68 229.6 0.0 1.8e-68 229.1 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ORX73226.1 - 1.8e-40 137.3 0.2 1.1e-39 134.9 0.0 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX73226.1 - 0.013 15.7 0.0 0.16 12.1 0.0 2.5 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus DUF3576 PF12100.8 ORX73226.1 - 0.16 12.1 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3576) SAGA-Tad1 PF12767.7 ORX73227.1 - 1.6e-40 139.3 0.0 2.9e-40 138.5 0.0 1.4 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit RRM_1 PF00076.22 ORX73228.1 - 1.1e-18 66.9 0.0 1.1e-18 66.8 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX73228.1 - 2e-07 31.1 0.0 5.2e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif SET PF00856.28 ORX73230.1 - 1.4e-25 90.7 0.3 3.1e-25 89.5 0.3 1.6 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 ORX73230.1 - 1.8e-14 54.3 10.2 1.8e-14 54.3 10.2 2.1 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.24 ORX73230.1 - 8.5e-12 44.8 0.2 1.6e-11 43.9 0.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain FXMRP1_C_core PF12235.8 ORX73230.1 - 1.1 9.9 8.0 1.9 9.1 8.0 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal CENP-S PF15630.6 ORX73231.1 - 5.1e-26 90.9 0.0 7.7e-26 90.3 0.0 1.2 1 1 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX73231.1 - 6.4e-07 29.5 0.0 7e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 ORX73231.1 - 0.023 14.8 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Pkinase PF00069.25 ORX73232.1 - 1.5e-71 240.9 0.1 3.1e-71 239.8 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73232.1 - 5.4e-52 176.6 0.3 1.2e-51 175.5 0.3 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX73232.1 - 2.2e-21 75.9 0.1 6.9e-21 74.4 0.1 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 ORX73232.1 - 3.6e-11 43.5 1.1 7.5e-11 42.5 1.1 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ORX73232.1 - 6.7e-07 28.9 0.1 3.6e-06 26.5 0.1 2.1 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX73232.1 - 8e-06 24.9 5.5 8e-06 24.9 5.5 2.4 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX73232.1 - 0.00015 20.8 1.0 0.00025 20.1 1.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain PH_11 PF15413.6 ORX73232.1 - 0.00025 21.4 5.9 0.0016 18.8 1.6 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 ORX73232.1 - 0.0045 16.7 0.9 0.094 12.4 0.0 2.3 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding KIND PF16474.5 ORX73232.1 - 0.05 13.5 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain APH PF01636.23 ORX73232.1 - 0.072 13.0 0.1 1.5 8.7 0.2 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family PH_3 PF14593.6 ORX73232.1 - 0.074 13.2 2.6 0.32 11.1 0.3 2.6 3 0 0 3 3 3 0 PH domain Kdo PF06293.14 ORX73232.1 - 0.078 12.3 0.4 0.22 10.9 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TFIIA PF03153.13 ORX73232.1 - 0.23 11.4 26.4 0.32 11.0 26.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.28 ORX73233.1 - 1.5e-32 113.8 0.0 1.8e-32 113.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX73233.1 - 0.031 14.7 0.1 0.12 12.8 0.1 1.9 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain BAR PF03114.18 ORX73234.1 - 2.1e-36 125.7 4.5 2.7e-36 125.4 4.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 ORX73234.1 - 4.5e-12 45.6 0.0 8.3e-12 44.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX73234.1 - 7.5e-09 35.1 0.0 1.7e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.5 ORX73234.1 - 2.5e-06 27.4 1.6 3.6e-06 26.8 1.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family BAR_2 PF10455.9 ORX73234.1 - 5.1e-06 25.8 0.1 7.5e-06 25.3 0.1 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_2 PF07653.17 ORX73234.1 - 0.00037 20.1 0.0 0.00078 19.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 ORX73234.1 - 0.026 14.3 0.1 0.046 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) OmpH PF03938.14 ORX73234.1 - 0.036 14.4 6.1 0.083 13.2 6.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WEMBL PF05701.11 ORX73234.1 - 0.19 10.4 2.8 0.26 9.9 2.8 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light HrpF PF06266.12 ORX73234.1 - 0.19 12.0 0.8 0.52 10.6 0.3 2.0 1 1 0 1 1 1 0 HrpF protein T7SS_ESX_EspC PF10824.8 ORX73234.1 - 1.2 9.6 5.0 0.51 10.9 1.5 2.3 2 0 0 2 2 1 0 Excreted virulence factor EspC, type VII ESX diderm DUF4407 PF14362.6 ORX73234.1 - 6.1 6.1 7.9 13 5.0 7.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) OPT PF03169.15 ORX73235.1 - 2.1e-44 152.2 12.7 5.6e-25 88.1 3.0 2.1 1 1 1 2 2 2 2 OPT oligopeptide transporter protein Glyco_hydro_61 PF03443.14 ORX73236.1 - 1.5e-52 178.6 0.3 2.4e-52 177.9 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydro_61 PF03443.14 ORX73237.1 - 1.1e-56 192.0 0.3 1.5e-56 191.6 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 ORX73237.1 - 0.0037 17.5 0.0 0.015 15.5 0.0 1.9 2 0 0 2 2 2 1 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF4625 PF15418.6 ORX73237.1 - 0.11 12.7 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) CBS PF00571.28 ORX73239.1 - 5.5e-31 106.8 15.1 6.9e-08 32.8 0.1 5.5 6 0 0 6 6 6 4 CBS domain PB1 PF00564.24 ORX73239.1 - 0.00026 20.9 0.0 0.0016 18.4 0.1 2.2 2 0 0 2 2 2 1 PB1 domain CDP-OH_P_tran_2 PF08009.11 ORX73240.1 - 3.2 7.7 7.5 12 5.8 1.4 2.2 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 Cwf_Cwc_15 PF04889.12 ORX73241.1 - 0.01 15.6 4.2 0.01 15.6 4.2 1.6 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2890 PF11081.8 ORX73241.1 - 0.35 11.0 11.2 1.4 9.0 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) ERM PF00769.19 ORX73241.1 - 0.57 10.0 8.1 0.17 11.7 1.2 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family zf-RanBP PF00641.18 ORX73242.1 - 2.6e-05 23.4 21.6 0.0022 17.2 6.0 3.3 2 2 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF3615 PF12274.8 ORX73242.1 - 0.031 14.8 4.3 3 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3615) zf-P11 PF03854.14 ORX73242.1 - 0.22 11.2 6.2 3.8 7.2 0.7 2.5 2 0 0 2 2 2 0 P-11 zinc finger MRNIP PF15749.5 ORX73242.1 - 3.2 8.5 6.6 15 6.3 1.3 2.5 2 0 0 2 2 2 0 MRN-interacting protein zf-Sec23_Sec24 PF04810.15 ORX73242.1 - 3.4 7.8 8.1 7.5 6.7 1.2 2.9 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-MIZ PF02891.20 ORX73242.1 - 4.2 7.2 12.7 5.2 6.9 0.2 3.3 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger zf-RanBP PF00641.18 ORX73243.1 - 5.5e-08 32.0 35.6 0.0003 20.0 9.1 4.1 4 1 0 4 4 4 3 Zn-finger in Ran binding protein and others DZR PF12773.7 ORX73243.1 - 0.52 10.4 18.9 4.5 7.4 11.1 2.6 1 1 2 3 3 3 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 ORX73243.1 - 4.6 7.2 21.1 2.2 8.2 1.5 3.8 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Zip PF02535.22 ORX73244.1 - 8e-26 91.0 14.6 4.1e-20 72.3 10.3 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter ATPase_gene1 PF09527.10 ORX73244.1 - 0.14 12.3 5.6 0.62 10.3 5.6 2.2 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DUF3245 PF11595.8 ORX73244.1 - 0.42 11.1 0.8 0.75 10.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) PSII_Pbs27 PF13326.6 ORX73245.1 - 0.077 13.3 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 Ubiq_cyt_C_chap PF03981.12 ORX73245.1 - 1.5 8.9 6.1 1.1 9.4 3.0 2.2 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone SOR_SNZ PF01680.17 ORX73246.1 - 9.1e-113 375.1 5.3 9.1e-113 375.1 5.3 1.6 2 0 0 2 2 2 1 SOR/SNZ family ThiG PF05690.14 ORX73246.1 - 1.3e-09 37.8 6.1 2.3e-07 30.4 0.2 2.4 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ORX73246.1 - 0.00013 21.2 1.4 0.33 10.0 0.1 2.7 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ORX73246.1 - 0.0027 17.2 0.6 0.088 12.3 0.0 2.5 2 1 0 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 ORX73246.1 - 0.0056 15.9 0.5 0.38 9.9 0.0 2.5 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase TetR_C_27 PF17935.1 ORX73246.1 - 0.019 15.0 0.0 0.061 13.4 0.0 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain IGPS PF00218.21 ORX73246.1 - 0.023 13.9 0.1 0.64 9.1 0.0 2.6 3 0 0 3 3 3 0 Indole-3-glycerol phosphate synthase NMO PF03060.15 ORX73246.1 - 0.098 12.0 6.4 0.47 9.8 0.2 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase MCM_lid PF17855.1 ORX73246.1 - 0.13 12.7 0.3 4 7.9 0.0 2.7 2 1 1 3 3 3 0 MCM AAA-lid domain UPF0542 PF15086.6 ORX73247.1 - 0.043 13.7 1.4 0.21 11.6 1.4 2.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 7tm_1 PF00001.21 ORX73247.1 - 0.4 10.0 23.4 0.04 13.3 18.2 1.8 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) DNA_mis_repair PF01119.19 ORX73251.1 - 4.3e-27 94.2 0.0 9.4e-27 93.1 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Mlh1_C PF16413.5 ORX73251.1 - 9.1e-27 94.1 0.2 4.2e-25 88.6 0.2 2.2 1 1 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus HATPase_c_3 PF13589.6 ORX73251.1 - 6.9e-13 48.6 0.0 1.2e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX73251.1 - 4.4e-07 30.4 0.0 9.1e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MRP-S28 PF10213.9 ORX73252.1 - 1.8e-28 99.5 0.2 2.5e-28 99.0 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Lipoprotein_1 PF00820.19 ORX73252.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Borrelia lipoprotein Sin_N PF04801.13 ORX73253.1 - 6.6e-45 154.1 0.0 8.1e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region V_ATPase_I PF01496.19 ORX73253.1 - 0.53 8.1 2.1 0.66 7.8 2.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATP_bind_3 PF01171.20 ORX73254.1 - 5.5e-50 169.7 0.0 8.1e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 ORX73254.1 - 0.00034 19.8 0.0 0.0006 19.0 0.0 1.4 1 0 0 1 1 1 1 NAD synthase SPO22 PF08631.10 ORX73254.1 - 0.0096 15.4 0.0 0.023 14.2 0.0 1.5 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like QueC PF06508.13 ORX73254.1 - 0.01 15.4 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 ORX73254.1 - 0.01 15.9 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 ORX73254.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase PALP PF00291.25 ORX73255.1 - 5.3e-64 216.5 0.1 6.6e-64 216.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ORX73255.1 - 2.6e-13 50.2 0.4 1.6e-07 31.6 0.1 3.4 3 1 1 4 4 4 2 CBS domain RRM_1 PF00076.22 ORX73256.1 - 7.3e-22 77.0 0.0 1e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX73256.1 - 2.5e-07 30.7 0.1 5.5e-07 29.6 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 ORX73256.1 - 0.0001 21.9 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX73256.1 - 0.037 14.0 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1314 PF07013.11 ORX73256.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) PRK PF00485.18 ORX73257.1 - 6.5e-26 91.3 0.0 1e-25 90.7 0.0 1.3 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 ORX73257.1 - 9.6e-06 25.0 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 ORX73257.1 - 0.011 15.5 0.1 0.73 9.5 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase TrwB_AAD_bind PF10412.9 ORX73257.1 - 0.17 10.8 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain RhoGEF PF00621.20 ORX73258.1 - 6.8e-35 120.9 1.9 6.8e-35 120.9 1.9 1.7 2 0 0 2 2 2 1 RhoGEF domain PH_10 PF15411.6 ORX73258.1 - 3.4e-26 91.9 0.2 7.1e-26 90.9 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 ORX73258.1 - 2.2e-25 88.7 0.1 5e-25 87.6 0.1 1.7 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 ORX73258.1 - 7e-13 48.3 0.0 3.3e-12 46.2 0.0 2.1 1 1 0 1 1 1 1 PB1 domain Proteasome PF00227.26 ORX73259.1 - 1.8e-51 174.3 0.0 2.3e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX73259.1 - 1e-11 44.3 0.1 2e-11 43.3 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RRM_1 PF00076.22 ORX73260.1 - 0.0013 18.5 0.0 2.4 8.1 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX73260.1 - 0.042 13.9 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GAF_3 PF13492.6 ORX73263.1 - 0.16 12.3 0.0 0.19 12.1 0.0 1.1 1 0 0 1 1 1 0 GAF domain Choline_kinase PF01633.20 ORX73264.1 - 7.5e-46 156.4 0.6 2.9e-44 151.2 0.0 3.0 2 1 1 3 3 3 1 Choline/ethanolamine kinase APH PF01636.23 ORX73264.1 - 0.0019 18.2 0.0 0.0038 17.2 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family WD40 PF00400.32 ORX73265.1 - 8.6e-22 77.0 0.8 0.00019 22.1 0.1 6.0 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73265.1 - 9.5e-14 51.5 0.0 0.058 13.7 0.0 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 ORX73265.1 - 7.5e-05 22.6 0.3 0.012 15.4 0.1 2.4 2 0 0 2 2 2 2 Lipoprotein LpqB beta-propeller domain WD40_like PF17005.5 ORX73265.1 - 0.0024 17.3 0.0 0.012 15.0 0.0 2.1 1 1 0 1 1 1 1 WD40-like domain VID27 PF08553.10 ORX73265.1 - 0.031 13.3 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 ORX73265.1 - 0.054 12.4 0.0 12 4.8 0.0 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PUF PF00806.19 ORX73267.1 - 3e-74 240.7 13.9 1.6e-09 36.9 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat sCache_2 PF17200.4 ORX73267.1 - 0.00036 20.4 0.7 1.3 8.9 0.0 4.5 4 1 1 5 5 5 1 Single Cache domain 2 DUF2709 PF10915.8 ORX73267.1 - 0.0021 17.3 1.6 0.18 11.0 0.1 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2709) baeRF_family8 PF18851.1 ORX73267.1 - 0.017 15.2 0.1 0.069 13.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 NARG2_C PF10505.9 ORX73267.1 - 0.023 14.2 0.1 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus DUF3509 PF12021.8 ORX73267.1 - 0.037 13.8 0.2 6.6 6.6 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3509) Malate_synthase PF01274.22 ORX73268.1 - 1.3e-216 720.0 0.0 1.4e-216 719.8 0.0 1.0 1 0 0 1 1 1 1 Malate synthase S4 PF01479.25 ORX73268.1 - 0.0078 15.9 0.0 0.91 9.3 0.0 2.8 2 0 0 2 2 2 1 S4 domain HpcH_HpaI PF03328.14 ORX73268.1 - 0.073 12.2 0.0 0.19 10.8 0.0 1.8 2 1 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family UCH PF00443.29 ORX73269.1 - 5.6e-14 52.3 0.0 1.7e-13 50.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX73269.1 - 0.00011 21.9 0.0 0.0048 16.5 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX73269.1 - 0.022 14.9 0.0 0.063 13.4 0.0 1.8 1 0 0 1 1 1 0 MATH domain MatE PF01554.18 ORX73270.1 - 2.8e-22 79.1 28.7 6.8e-13 48.6 5.3 3.4 3 1 0 3 3 3 2 MatE WD40 PF00400.32 ORX73271.1 - 1.7e-16 60.3 11.5 7.7e-06 26.6 0.2 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73271.1 - 2.1e-06 27.9 0.2 2 8.8 0.0 4.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX73271.1 - 0.4 9.6 2.0 27 3.6 0.1 3.1 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nop PF01798.18 ORX73272.1 - 4e-87 291.5 0.0 7.4e-87 290.6 0.0 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ORX73272.1 - 1.9e-20 73.0 0.2 7.1e-20 71.2 0.2 2.0 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Med19 PF10278.9 ORX73272.1 - 7.3 6.5 18.4 81 3.1 17.4 2.5 3 0 0 3 3 3 0 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.11 ORX73272.1 - 9.1 6.3 20.9 14 5.7 20.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DHFR_1 PF00186.19 ORX73273.1 - 1.5e-31 109.2 0.0 3.5e-31 108.1 0.0 1.5 1 1 0 1 1 1 1 Dihydrofolate reductase PPR_2 PF13041.6 ORX73274.1 - 4.9e-12 45.9 0.0 0.001 19.2 0.0 5.6 6 1 0 6 6 6 2 PPR repeat family PPR PF01535.20 ORX73274.1 - 8.2e-09 35.1 0.0 0.21 11.9 0.0 6.5 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 ORX73274.1 - 3.2e-07 30.3 0.0 0.2 11.8 0.0 4.7 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX73274.1 - 8.4e-06 25.3 5.3 0.39 10.0 0.0 4.1 1 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP Snf7 PF03357.21 ORX73276.1 - 2.4e-05 24.0 1.2 3.1e-05 23.6 1.2 1.1 1 0 0 1 1 1 1 Snf7 DDHD PF02862.17 ORX73277.1 - 0.16 12.1 10.5 0.21 11.7 10.5 1.2 1 0 0 1 1 1 0 DDHD domain Spem1 PF15670.5 ORX73277.1 - 0.17 11.4 10.0 0.22 11.1 10.0 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 FAM60A PF15396.6 ORX73277.1 - 0.42 10.6 11.4 0.47 10.4 11.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A TFIIA PF03153.13 ORX73277.1 - 0.58 10.1 21.0 0.66 9.9 21.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 ORX73277.1 - 1.1 7.0 8.4 1.3 6.8 8.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Macoilin PF09726.9 ORX73277.1 - 1.9 6.9 15.3 2.2 6.7 15.3 1.0 1 0 0 1 1 1 0 Macoilin family Suf PF05843.14 ORX73277.1 - 2.3 8.1 14.7 2.6 7.9 14.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MSA_2 PF00985.17 ORX73277.1 - 2.4 8.5 21.7 3.1 8.1 21.7 1.1 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family Neur_chan_memb PF02932.16 ORX73277.1 - 2.6 8.0 12.3 3.1 7.8 12.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ORX73277.1 - 3 6.5 22.0 3.6 6.3 22.0 1.1 1 0 0 1 1 1 0 Presenilin CDK5_activator PF03261.15 ORX73277.1 - 3.2 7.2 12.4 3.8 7.0 12.4 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF5427 PF10310.9 ORX73277.1 - 4.1 6.3 20.9 4.9 6.0 20.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PBP1_TM PF14812.6 ORX73277.1 - 4.8 7.6 10.9 8.6 6.8 0.2 2.2 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Hamartin PF04388.12 ORX73277.1 - 8.1 5.0 15.7 9.3 4.8 15.7 1.0 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 ORX73277.1 - 8.3 5.4 18.8 9.7 5.1 18.8 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Apt1 PF10351.9 ORX73277.1 - 9.4 5.0 16.1 11 4.7 16.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Zip PF02535.22 ORX73277.1 - 9.6 5.3 13.7 12 5.1 13.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.11 ORX73278.1 - 0.54 8.3 2.1 0.68 7.9 2.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NICE-1 PF15845.5 ORX73278.1 - 1.6 9.5 16.0 0.15 12.8 10.8 2.1 2 0 0 2 2 2 0 Cysteine-rich C-terminal 1 family zf-RING_4 PF14570.6 ORX73279.1 - 3.3e-20 71.6 11.3 6.2e-20 70.7 11.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 ORX73279.1 - 1.2e-08 34.6 0.0 2.5e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX73279.1 - 0.00023 21.1 0.0 0.00052 20.0 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-RING_2 PF13639.6 ORX73279.1 - 0.00071 19.9 9.2 0.0014 18.9 9.2 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ORX73279.1 - 0.0008 19.2 5.8 0.045 13.6 2.3 2.4 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-UDP PF14569.6 ORX73279.1 - 0.0085 16.2 2.9 0.016 15.3 2.9 1.4 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_5 PF14634.6 ORX73279.1 - 0.013 15.5 8.5 0.024 14.6 8.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Baculo_IE-1 PF05290.11 ORX73279.1 - 0.031 14.2 3.2 0.057 13.4 3.2 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.6 ORX73279.1 - 0.035 13.9 8.4 0.077 12.9 8.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 ORX73279.1 - 0.064 13.1 1.6 2.3 8.2 0.1 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Nup35_RRM PF05172.13 ORX73279.1 - 0.07 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-RING_UBOX PF13445.6 ORX73279.1 - 0.28 11.2 6.2 0.43 10.7 4.6 2.0 1 1 1 2 2 2 0 RING-type zinc-finger DUF4551 PF15087.6 ORX73280.1 - 1.4 7.7 7.4 1.8 7.3 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SH2_2 PF14633.6 ORX73281.1 - 1.9e-52 177.8 0.0 6.2e-51 172.9 0.0 2.7 2 1 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 ORX73281.1 - 7.1e-29 100.2 0.1 1.9e-28 98.8 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif YqgF PF14639.6 ORX73281.1 - 8.3e-18 64.6 0.0 1.9e-17 63.5 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 ORX73281.1 - 1.9e-15 57.3 0.0 4.6e-15 56.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 S1 PF00575.23 ORX73281.1 - 5.7e-10 39.4 0.1 1.5e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HHH_9 PF17674.1 ORX73281.1 - 3.2e-08 34.3 0.2 0.00047 21.0 0.0 3.0 2 0 0 2 2 2 2 HHH domain SPT6_acidic PF14632.6 ORX73281.1 - 7.4e-08 32.9 12.3 7.4e-08 32.9 12.3 4.9 3 2 1 4 4 3 1 Acidic N-terminal SPT6 SH2 PF00017.24 ORX73281.1 - 1.1e-06 28.7 0.0 8.7e-06 25.8 0.0 2.4 2 0 0 2 2 2 1 SH2 domain HHH_3 PF12836.7 ORX73281.1 - 0.0043 17.3 0.0 0.0099 16.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tex_YqgF PF16921.5 ORX73281.1 - 0.021 15.3 0.0 0.045 14.2 0.0 1.5 1 0 0 1 1 1 0 Tex protein YqgF-like domain PHC2_SAM_assoc PF16616.5 ORX73281.1 - 0.35 11.7 8.1 0.37 11.6 3.7 2.7 2 0 0 2 2 2 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Transferase PF02458.15 ORX73282.1 - 3.7e-18 65.4 0.0 6.7e-18 64.6 0.0 1.4 1 1 0 1 1 1 1 Transferase family Transferase PF02458.15 ORX73283.1 - 5.9e-19 68.0 0.0 7.6e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Transferase family Condensation PF00668.20 ORX73283.1 - 0.23 10.1 0.0 0.38 9.4 0.0 1.2 1 0 0 1 1 1 0 Condensation domain Transferase PF02458.15 ORX73284.1 - 3.3e-31 108.4 0.0 4.4e-31 108.0 0.0 1.0 1 0 0 1 1 1 1 Transferase family DJ-1_PfpI PF01965.24 ORX73286.1 - 7e-08 32.4 0.0 2e-07 31.0 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ORX73286.1 - 0.00058 19.6 0.0 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 ThiJ/PfpI family-like CorA PF01544.18 ORX73287.1 - 4.4e-40 137.8 1.0 5.8e-40 137.4 1.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Abhydrolase_1 PF00561.20 ORX73288.1 - 3.5e-06 26.9 0.0 9.2e-06 25.5 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX73288.1 - 2.5e-05 25.0 0.3 6e-05 23.7 0.3 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX73288.1 - 0.00016 21.1 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF4870 PF09685.10 ORX73288.1 - 7.4 6.7 9.5 3.1 7.9 4.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4870) CorA PF01544.18 ORX73289.1 - 3.4e-33 115.2 0.2 2.8e-17 63.0 0.0 2.4 3 0 0 3 3 3 2 CorA-like Mg2+ transporter protein Pmp3 PF01679.17 ORX73290.1 - 2.4e-23 82.1 6.0 2.6e-23 81.9 6.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator CHCH PF06747.13 ORX73291.1 - 3.2e-05 23.9 4.4 0.0001 22.4 4.4 1.9 1 1 0 1 1 1 1 CHCH domain CX9C PF16860.5 ORX73291.1 - 0.0067 16.4 1.7 0.0067 16.4 1.7 2.0 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Chromo PF00385.24 ORX73292.1 - 0.00081 19.3 0.0 0.0019 18.0 0.0 1.6 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-C2H2 PF00096.26 ORX73293.1 - 7.5e-35 117.5 77.9 4.2e-06 26.9 2.9 10.2 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX73293.1 - 3.2e-23 80.4 75.7 1.9e-05 25.1 1.6 10.1 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX73293.1 - 1.4e-20 72.7 67.6 3.9e-06 27.0 2.8 10.0 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX73293.1 - 0.00077 19.7 32.0 0.0081 16.4 0.8 7.3 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX73293.1 - 0.0025 17.8 5.5 0.017 15.1 1.3 8.2 10 0 0 10 10 10 3 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 ORX73293.1 - 0.0089 15.9 3.8 0.0089 15.9 3.8 4.7 4 1 1 5 5 5 1 SprT-like zinc ribbon domain zf_Hakai PF18408.1 ORX73293.1 - 0.052 13.3 0.0 0.052 13.3 0.0 6.8 8 0 0 8 8 8 0 C2H2 Hakai zinc finger domain zf-met PF12874.7 ORX73293.1 - 0.068 13.6 0.7 0.068 13.6 0.7 7.5 10 0 0 10 10 10 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 ORX73293.1 - 2.9 8.6 30.6 1.1 9.9 0.4 6.5 3 2 4 7 7 7 0 FOXP coiled-coil domain Spt46 PF17734.1 ORX73293.1 - 8.1 6.2 15.7 2.9 7.6 1.2 3.5 2 1 2 4 4 4 0 Spermatogenesis-associated protein 46 zf-DNA_Pol PF08996.10 ORX73293.1 - 9.2 6.0 19.6 2.1 8.0 1.0 3.9 1 1 2 3 3 3 0 DNA Polymerase alpha zinc finger zf_UBZ PF18439.1 ORX73293.1 - 9.7 5.9 15.1 21 4.8 1.3 5.5 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Gtr1_RagA PF04670.12 ORX73294.1 - 3.5e-38 131.3 0.0 5e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX73294.1 - 0.00041 19.8 0.0 0.00088 18.7 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ORX73294.1 - 0.012 15.1 0.0 0.039 13.4 0.0 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 ORX73294.1 - 0.049 14.1 0.0 0.16 12.4 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX73294.1 - 0.087 12.9 0.0 0.29 11.2 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase Glyco_transf_15 PF01793.16 ORX73295.1 - 5.1e-112 374.3 11.9 6.1e-112 374.1 11.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4363 PF14276.6 ORX73295.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) CorA PF01544.18 ORX73296.1 - 2.5e-34 118.9 0.5 3.3e-34 118.6 0.5 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Abhydrolase_3 PF07859.13 ORX73298.1 - 7.8e-46 156.6 0.0 1.1e-45 156.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX73298.1 - 7.8e-10 38.2 0.0 1.2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 ORX73298.1 - 0.03 14.9 0.1 0.044 14.4 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family BAAT_C PF08840.11 ORX73298.1 - 0.085 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 ORX73298.1 - 0.14 11.4 0.1 0.25 10.6 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 ORX73298.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein COesterase PF00135.28 ORX73298.1 - 0.16 10.8 0.8 1.7 7.4 0.1 2.0 2 0 0 2 2 2 0 Carboxylesterase family Glyco_transf_15 PF01793.16 ORX73299.1 - 5.1e-107 357.9 12.9 6.1e-107 357.6 12.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pkinase PF00069.25 ORX73300.1 - 8.3e-65 218.8 0.0 1.1e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73300.1 - 4e-33 114.8 0.0 6.6e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX73300.1 - 0.00019 22.1 0.0 0.00066 20.3 0.1 1.9 2 1 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 ORX73300.1 - 0.0089 15.4 0.0 0.69 9.2 0.0 2.7 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nab1 PF04902.12 ORX73300.1 - 0.076 13.4 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Conserved region in Nab1 Kinase-like PF14531.6 ORX73300.1 - 0.11 11.8 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like CLPTM1 PF05602.12 ORX73302.1 - 2.9e-119 398.9 0.4 4.1e-119 398.4 0.4 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ORX73302.1 - 9.3e-05 22.1 0.4 0.0089 15.8 0.1 2.6 2 0 0 2 2 2 2 PQ loop repeat DUF1681 PF07933.14 ORX73303.1 - 3.1e-53 179.5 0.0 3.6e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Aa_trans PF01490.18 ORX73304.1 - 1.1e-54 185.8 35.5 1.3e-54 185.5 35.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX73304.1 - 8.9e-07 28.1 32.4 8.9e-07 28.1 32.4 2.1 1 1 1 2 2 2 1 Amino acid permease PX PF00787.24 ORX73305.1 - 5.9e-10 39.1 0.0 1.5e-09 37.8 0.0 1.7 2 0 0 2 2 2 1 PX domain Pkinase PF00069.25 ORX73306.1 - 1.4e-61 208.2 0.0 1.7e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73306.1 - 8.9e-31 107.1 0.0 1.6e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX73306.1 - 0.026 13.9 0.0 0.92 8.8 0.0 2.1 1 1 1 2 2 2 0 Kinase-like Kdo PF06293.14 ORX73306.1 - 0.064 12.6 0.0 0.53 9.6 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX73306.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family CorA PF01544.18 ORX73307.1 - 0.0042 16.4 0.0 0.87 8.8 0.0 2.1 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein TUDOR_5 PF18359.1 ORX73308.1 - 0.14 11.8 0.0 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain 1 Glyco_transf_15 PF01793.16 ORX73309.1 - 1.1e-119 399.5 13.7 1.4e-119 399.2 13.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DAPDH_C PF16654.5 ORX73309.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain Pex19 PF04614.12 ORX73309.1 - 0.028 14.2 0.9 0.045 13.5 0.9 1.2 1 0 0 1 1 1 0 Pex19 protein family DUF3390 PF11870.8 ORX73309.1 - 0.17 12.3 1.0 0.44 11.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) Cytochrom_C PF00034.21 ORX73310.1 - 1.1e-11 45.6 0.1 1.7e-11 45.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ORX73310.1 - 3.5e-09 36.9 1.9 2.5e-08 34.1 1.9 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ORX73310.1 - 0.00011 21.9 0.4 0.0027 17.4 0.1 2.2 2 0 0 2 2 2 1 Cytochrome c-550 domain Cytochrome-c551 PF10643.9 ORX73310.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 GST_N_3 PF13417.6 ORX73311.1 - 4e-09 36.8 0.0 6.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX73311.1 - 6.3e-08 32.8 0.0 1.3e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX73311.1 - 7.8e-05 22.6 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX73311.1 - 0.023 15.0 0.0 0.049 14.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX73311.1 - 0.029 14.6 0.0 0.056 13.6 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ORX73311.1 - 0.029 14.9 0.0 0.046 14.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX73312.1 - 2.8e-05 24.0 0.0 4.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX73312.1 - 0.011 15.9 0.0 0.019 15.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX73312.1 - 0.03 14.6 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ORX73312.1 - 0.052 14.1 0.0 0.075 13.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MLTR_LBD PF17765.1 ORX73312.1 - 0.087 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain SBDS_C PF09377.10 ORX73312.1 - 0.1 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 SBDS protein C-terminal domain GST_C_2 PF13410.6 ORX73313.1 - 0.0005 20.0 0.0 0.00097 19.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX73313.1 - 0.027 14.7 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ORX73313.1 - 0.15 12.7 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sugar_tr PF00083.24 ORX73314.1 - 1.2e-71 241.9 12.0 5.6e-41 140.8 2.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX73314.1 - 9.5e-11 41.2 8.7 1.5e-08 33.9 1.6 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily PSI PF01437.25 ORX73314.1 - 0.0014 19.1 5.3 0.0024 18.3 5.3 1.4 1 0 0 1 1 1 1 Plexin repeat Leu_Phe_trans PF03588.14 ORX73314.1 - 0.045 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase DUF2207 PF09972.9 ORX73314.1 - 2.2 7.0 9.3 3.5 6.3 2.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4293 PF14126.6 ORX73314.1 - 8.6 6.6 13.3 0.27 11.5 6.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Pkinase PF00069.25 ORX73316.1 - 1.6e-39 135.8 0.1 1.9e-39 135.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73316.1 - 9.8e-23 80.8 0.1 1.2e-22 80.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX73316.1 - 5.9e-08 32.4 0.0 6.8e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX73316.1 - 1.1e-07 31.0 0.6 1.3e-07 30.7 0.3 1.2 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX73316.1 - 0.00014 21.0 0.0 0.00014 21.0 0.0 1.0 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX73316.1 - 0.00062 19.8 0.4 0.00081 19.4 0.4 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX73316.1 - 0.0018 17.6 0.6 0.0021 17.4 0.6 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ORX73316.1 - 0.0039 16.2 0.0 0.0045 16.0 0.0 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.11 ORX73316.1 - 0.021 13.9 0.1 0.028 13.5 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Citrate_bind PF16114.5 ORX73317.1 - 5.7e-93 309.3 0.2 1.8e-92 307.7 0.2 1.9 2 0 0 2 2 2 1 ATP citrate lyase citrate-binding Ligase_CoA PF00549.19 ORX73317.1 - 1.9e-16 60.3 0.1 4e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ORX73317.1 - 2.3e-12 47.4 0.0 8.4e-12 45.6 0.0 2.1 1 0 0 1 1 1 1 CoA binding domain Citrate_synt PF00285.21 ORX73317.1 - 7.3e-12 45.0 0.0 4.8e-11 42.3 0.0 2.3 2 1 0 2 2 2 1 Citrate synthase, C-terminal domain Succ_CoA_lig PF13607.6 ORX73317.1 - 1.7e-06 27.9 0.0 4.8e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain SNURF PF07192.11 ORX73318.1 - 0.64 9.9 3.0 1.5 8.8 0.4 2.3 2 0 0 2 2 2 0 SNURF/RPN4 protein PRIMA1 PF16101.5 ORX73318.1 - 0.75 9.8 5.2 1 9.4 0.9 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CRAL_TRIO PF00650.20 ORX73319.1 - 1e-38 132.6 0.0 1.6e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX73319.1 - 8.5e-13 48.3 0.0 2e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX73319.1 - 9.1e-10 38.8 0.1 1.4e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CdhD PF03599.16 ORX73319.1 - 0.027 13.2 0.0 0.041 12.6 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DNA_pol_A_exoN PF18305.1 ORX73319.1 - 0.056 13.7 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 3' to 5' exonuclease C-terminal domain Glyco_hydro_18 PF00704.28 ORX73320.1 - 1.2e-56 192.8 0.2 4.9e-56 190.7 0.2 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Inhibitor_I78 PF11720.8 ORX73321.1 - 0.00048 20.1 0.1 0.00067 19.7 0.1 1.4 1 1 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX73321.1 - 0.057 14.1 0.0 0.087 13.5 0.0 1.3 1 0 0 1 1 1 0 Potato inhibitor I family bZIP_1 PF00170.21 ORX73322.1 - 0.00028 20.9 7.4 0.00028 20.9 7.4 1.7 2 0 0 2 2 2 1 bZIP transcription factor CCD48 PF15799.5 ORX73322.1 - 0.004 15.5 0.5 0.0042 15.5 0.5 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 Rootletin PF15035.6 ORX73322.1 - 0.013 15.6 1.4 0.016 15.2 1.4 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion bZIP_Maf PF03131.17 ORX73322.1 - 0.021 15.3 6.6 0.025 15.1 5.1 1.7 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_2 PF07716.15 ORX73322.1 - 0.056 13.5 8.7 0.1 12.7 8.7 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Co_AT_N PF12557.8 ORX73322.1 - 2.6 8.1 8.6 5.2 7.1 8.6 1.5 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal bZIP_2 PF07716.15 ORX73323.1 - 4.8e-07 29.7 13.6 4.8e-07 29.7 13.6 1.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX73323.1 - 3.1e-05 24.0 12.0 3.1e-05 24.0 12.0 2.1 1 1 1 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX73323.1 - 6.2e-05 23.4 7.4 0.00015 22.2 7.4 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Nop53 PF07767.11 ORX73323.1 - 0.0051 16.3 2.5 0.008 15.6 2.5 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) FPP PF05911.11 ORX73323.1 - 0.0065 14.7 3.3 0.0087 14.3 3.3 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DUF3552 PF12072.8 ORX73323.1 - 0.014 14.8 2.9 0.019 14.4 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF3450 PF11932.8 ORX73323.1 - 0.034 13.4 4.3 0.04 13.2 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF5320 PF17253.2 ORX73323.1 - 0.039 15.0 0.3 0.072 14.2 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) UPF0242 PF06785.11 ORX73323.1 - 0.046 13.8 2.0 0.069 13.3 2.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2259 PF10016.9 ORX73323.1 - 0.073 13.0 1.7 0.11 12.5 1.7 1.3 1 0 0 1 1 1 0 Predicted secreted protein (DUF2259) CASP_C PF08172.12 ORX73323.1 - 0.078 12.3 6.7 0.047 13.0 0.7 2.2 2 0 0 2 2 2 0 CASP C terminal YabA PF06156.13 ORX73323.1 - 0.083 13.5 1.7 0.16 12.7 1.7 1.6 1 0 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 ORX73323.1 - 0.11 13.1 8.7 0.51 10.9 8.7 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DivIC PF04977.15 ORX73323.1 - 0.14 11.9 5.3 2.5 7.9 0.1 2.3 1 1 1 2 2 2 0 Septum formation initiator TolA_bind_tri PF16331.5 ORX73323.1 - 0.16 12.1 8.5 0.11 12.5 4.8 2.5 1 1 2 3 3 3 0 TolA binding protein trimerisation HAUS-augmin3 PF14932.6 ORX73323.1 - 0.18 11.4 6.4 0.25 10.9 6.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 C4bp_oligo PF18453.1 ORX73323.1 - 0.19 11.9 1.5 0.36 11.1 1.5 1.4 1 0 0 1 1 1 0 Oligomerization domain of C4b-binding protein alpha Fmp27_WPPW PF10359.9 ORX73323.1 - 0.25 10.1 3.9 0.33 9.8 3.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Ribosomal_S20p PF01649.18 ORX73323.1 - 0.3 11.8 5.2 0.13 12.9 2.1 1.9 2 0 0 2 2 2 0 Ribosomal protein S20 FliD_N PF02465.18 ORX73323.1 - 0.42 11.3 14.0 0.15 12.7 3.1 2.6 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Fib_alpha PF08702.10 ORX73323.1 - 0.51 10.5 4.5 0.71 10.1 1.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 ORX73323.1 - 0.81 10.1 8.0 1.4 9.4 6.9 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Spc24 PF08286.11 ORX73323.1 - 6.5 7.1 7.2 48 4.3 7.2 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 bZIP_2 PF07716.15 ORX73324.1 - 1.6e-07 31.3 22.4 0.001 19.1 4.8 2.4 2 0 0 2 2 2 2 Basic region leucine zipper DUF4799 PF16056.5 ORX73324.1 - 0.0034 16.6 10.4 0.0054 15.9 10.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4799) Fzo_mitofusin PF04799.13 ORX73324.1 - 0.054 13.0 7.7 0.52 9.8 0.5 2.1 2 0 0 2 2 2 0 fzo-like conserved region DUF4298 PF14131.6 ORX73324.1 - 0.058 13.4 0.5 0.15 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) bZIP_1 PF00170.21 ORX73324.1 - 0.071 13.2 19.6 0.095 12.8 4.3 2.3 2 0 0 2 2 2 0 bZIP transcription factor SlyX PF04102.12 ORX73324.1 - 0.096 13.3 4.8 0.9 10.2 0.0 2.7 2 0 0 2 2 2 0 SlyX bZIP_Maf PF03131.17 ORX73324.1 - 0.1 13.2 22.0 0.92 10.1 5.1 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor Cas_Csy4 PF09618.10 ORX73324.1 - 0.17 12.0 12.2 1.6 8.9 3.2 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) zf-CpG_bind_C PF12269.8 ORX73324.1 - 0.66 9.7 5.8 1.6 8.4 0.7 2.1 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain SAGA-Tad1 PF12767.7 ORX73324.1 - 0.66 9.7 8.0 0.92 9.2 8.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit ABC_tran_CTD PF16326.5 ORX73324.1 - 0.83 9.9 5.8 9.8 6.5 2.3 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF5082 PF16888.5 ORX73324.1 - 2.6 8.3 8.0 14 6.0 0.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF1465 PF07323.12 ORX73324.1 - 4.8 7.0 12.7 2.9 7.7 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) Glyco_hydro_81 PF03639.13 ORX73325.1 - 5.1e-33 114.6 0.5 1.7e-32 112.9 0.5 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain zf-met PF12874.7 ORX73326.1 - 0.00015 22.0 5.8 0.0012 19.2 1.9 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ORX73326.1 - 0.00057 20.2 4.8 0.14 12.6 2.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ORX73326.1 - 0.0092 16.2 4.7 0.022 15.0 1.9 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX73326.1 - 0.12 13.3 5.0 0.35 11.8 1.7 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Trypsin PF00089.26 ORX73328.1 - 0.04 13.7 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 Trypsin SKG6 PF08693.10 ORX73329.1 - 1.8e-05 24.1 0.5 3.3e-05 23.2 0.5 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Trypsin PF00089.26 ORX73330.1 - 0.0047 16.8 0.7 0.03 14.1 0.0 2.1 2 0 0 2 2 2 1 Trypsin SKG6 PF08693.10 ORX73331.1 - 5.1e-06 25.8 1.3 8.9e-06 25.0 1.3 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 ORX73331.1 - 0.00028 20.7 0.0 0.00038 20.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Rax2 PF12768.7 ORX73331.1 - 0.00038 20.0 0.0 0.00052 19.5 0.0 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity SCF PF02404.15 ORX73331.1 - 0.02 14.2 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Stem cell factor Mid2 PF04478.12 ORX73331.1 - 0.036 13.9 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SKG6 PF08693.10 ORX73332.1 - 1.1e-05 24.7 0.4 2.8e-05 23.4 0.4 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF202 PF02656.15 ORX73334.1 - 3.5e-07 30.6 0.3 7.3e-07 29.5 0.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF202) MFS_1 PF07690.16 ORX73335.1 - 7.8e-40 136.9 54.2 4.1e-39 134.5 53.0 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX73335.1 - 1e-06 27.9 11.8 1e-06 27.9 11.8 3.5 2 1 1 3 3 3 2 Sugar (and other) transporter DUF2615 PF11027.8 ORX73335.1 - 0.54 10.4 0.0 0.54 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) OATP PF03137.20 ORX73335.1 - 1.5 7.0 17.3 0.066 11.5 5.1 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family APG5 PF04106.12 ORX73337.1 - 1.1e-48 165.8 0.0 1.6e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 YbfN PF13982.6 ORX73337.1 - 0.16 12.2 0.1 0.28 11.5 0.1 1.3 1 0 0 1 1 1 0 YbfN-like lipoprotein ATP-synt_ab PF00006.25 ORX73338.1 - 9.7e-62 208.4 0.0 1.7e-61 207.6 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX73338.1 - 4e-23 81.7 0.5 8e-23 80.8 0.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 ORX73338.1 - 0.027 13.8 0.4 0.048 13.0 0.4 1.4 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.22 ORX73338.1 - 0.038 13.2 0.1 0.061 12.5 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 ORX73338.1 - 0.08 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 ORX73338.1 - 0.083 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ORX73338.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ORX73338.1 - 0.16 12.4 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP-synt_DE_N PF02823.16 ORX73339.1 - 7.5e-14 51.4 0.0 1.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SKG6 PF08693.10 ORX73340.1 - 3.1e-07 29.7 0.4 5.6e-07 28.9 0.4 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF1180 PF06679.12 ORX73340.1 - 0.01 16.2 0.0 0.016 15.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Glyco_hydro_46 PF01374.18 ORX73341.1 - 1.8e-42 145.4 1.6 2.3e-42 145.0 1.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 46 Glyco_hydro_46 PF01374.18 ORX73342.1 - 3.2e-07 30.2 0.8 1.8e-05 24.5 0.1 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 46 dDENN PF03455.19 ORX73342.1 - 0.048 13.7 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 dDENN domain Cellulase PF00150.18 ORX73344.1 - 2.5e-05 23.9 0.2 0.00019 21.0 0.2 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) NAD_binding_1 PF00175.21 ORX73346.1 - 2.8e-20 73.0 0.0 1.4e-18 67.5 0.0 2.2 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX73346.1 - 2.7e-08 34.1 0.0 5e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ORX73346.1 - 2.1e-06 28.0 0.0 0.0005 20.2 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAT PF02259.23 ORX73348.1 - 7.3e-69 232.6 7.2 1.7e-48 165.6 4.2 3.5 2 1 0 2 2 2 2 FAT domain DUF3385 PF11865.8 ORX73348.1 - 2.9e-38 131.3 2.6 1.8e-30 106.0 0.0 5.8 5 0 0 5 5 5 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 ORX73348.1 - 3.3e-36 125.4 0.0 7.1e-29 101.3 0.0 2.9 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 ORX73348.1 - 7.2e-25 87.3 0.8 2.9e-23 82.2 0.1 3.8 3 0 0 3 3 2 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 ORX73348.1 - 1.2e-13 51.2 10.8 0.35 11.3 1.5 10.5 7 2 4 11 11 11 3 HEAT repeats FATC PF02260.20 ORX73348.1 - 1.9e-11 43.6 0.5 7.6e-11 41.6 0.5 2.2 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 ORX73348.1 - 1.8e-09 37.0 12.1 1.8 9.1 0.0 8.8 8 0 0 8 8 7 3 HEAT repeat HEAT_EZ PF13513.6 ORX73348.1 - 7.9e-06 26.3 20.4 0.15 12.6 0.1 9.6 7 3 2 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 ORX73348.1 - 4.2e-05 23.6 4.1 3 7.8 0.2 5.5 6 0 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 ORX73348.1 - 0.00012 21.7 0.4 0.098 12.2 0.0 4.2 4 0 0 4 4 4 1 Tti2 family Adaptin_N PF01602.20 ORX73348.1 - 0.00029 19.5 16.0 0.0023 16.6 0.9 5.2 4 1 1 5 5 5 1 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX73348.1 - 0.0068 17.0 0.0 15 6.3 0.0 4.6 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region DUF2937 PF11157.8 ORX73348.1 - 0.069 12.9 0.1 1.2 8.9 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) MOR2-PAG1_C PF14225.6 ORX73348.1 - 0.24 11.2 6.0 1.8 8.4 0.0 4.8 5 0 0 5 5 5 0 Cell morphogenesis C-terminal Adaptin_N PF01602.20 ORX73349.1 - 1.7e-80 271.1 2.5 2.7e-80 270.4 2.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ORX73349.1 - 1.9e-47 160.4 0.0 4.7e-47 159.2 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ORX73349.1 - 1.8e-45 154.3 0.5 3.8e-45 153.2 0.5 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.7 ORX73349.1 - 6.5e-11 42.5 3.0 1.2e-06 28.7 0.1 2.9 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX73349.1 - 9.4e-10 38.8 9.3 0.0016 18.8 0.1 5.5 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.22 ORX73349.1 - 6.6e-06 25.9 1.1 4.4 7.8 0.0 5.5 4 0 0 4 4 4 1 HEAT repeat DUF5578 PF17741.1 ORX73349.1 - 0.0011 18.5 0.5 0.068 12.6 0.2 2.9 2 1 1 3 3 3 1 Family of unknown function (DUF5578) Coatomer_g_Cpla PF16381.5 ORX73349.1 - 0.012 15.7 0.0 0.16 12.1 0.0 2.3 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform MMS22L_C PF14911.6 ORX73349.1 - 0.035 13.2 0.1 3 6.8 0.0 2.9 3 0 0 3 3 3 0 S-phase genomic integrity recombination mediator, C-terminal HEAT_EZ PF13513.6 ORX73349.1 - 0.041 14.4 0.4 13 6.4 0.1 4.4 3 0 0 3 3 3 0 HEAT-like repeat RRM_1 PF00076.22 ORX73350.1 - 3.4e-24 84.5 0.0 7.3e-14 51.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PMI_typeI PF01238.21 ORX73351.1 - 2.7e-117 392.1 0.0 3e-117 392.0 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 ORX73351.1 - 3.3e-05 23.5 0.0 0.23 11.2 0.0 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 ORX73351.1 - 0.00012 22.0 0.1 0.42 10.5 0.0 3.0 3 0 0 3 3 3 2 AraC-like ligand binding domain Aminotran_1_2 PF00155.21 ORX73352.1 - 1.6e-87 294.1 0.0 1.8e-87 293.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Macscav_rec PF03523.13 ORX73352.1 - 0.13 12.1 0.2 30 4.6 0.0 2.9 3 0 0 3 3 3 0 Macrophage scavenger receptor NUDIX PF00293.28 ORX73353.1 - 5.8e-28 97.5 0.0 7.7e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF3113 PF11310.8 ORX73353.1 - 0.12 12.3 0.6 0.29 11.1 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) Ribonuc_L-PSP PF01042.21 ORX73354.1 - 1e-23 83.6 0.1 1.3e-23 83.3 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP BCDHK_Adom3 PF10436.9 ORX73355.1 - 2.4e-28 99.0 0.1 3.6e-28 98.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX73355.1 - 3.1e-13 50.2 0.0 5.4e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX73355.1 - 0.0033 17.3 0.0 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Transferase PF02458.15 ORX73356.1 - 1.1e-19 70.4 0.0 1.5e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Transferase family Questin_oxidase PF14027.6 ORX73357.1 - 9e-77 258.9 0.5 1.1e-76 258.6 0.5 1.1 1 0 0 1 1 1 1 Questin oxidase-like TAFII55_N PF04658.13 ORX73358.1 - 1e-39 135.8 0.2 1e-39 135.8 0.2 1.9 2 1 0 2 2 2 1 TAFII55 protein conserved region D123 PF07065.14 ORX73358.1 - 0.029 13.5 1.6 0.054 12.6 1.6 1.4 1 0 0 1 1 1 0 D123 Phage_Gp19 PF09355.10 ORX73358.1 - 0.072 13.5 1.1 0.1 13.0 0.2 1.7 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 FAM76 PF16046.5 ORX73358.1 - 0.15 11.4 2.6 0.21 10.9 2.6 1.4 1 0 0 1 1 1 0 FAM76 protein TRAF_BIRC3_bd PF16673.5 ORX73358.1 - 0.56 10.0 6.6 0.15 11.8 0.9 2.7 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Voldacs PF03517.13 ORX73358.1 - 0.63 10.2 8.7 0.99 9.5 8.7 1.4 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling CDC45 PF02724.14 ORX73358.1 - 4.5 5.4 13.3 5.2 5.2 13.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1772 PF08592.11 ORX73359.1 - 0.00026 21.3 2.6 0.00026 21.3 2.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) zf-U1 PF06220.12 ORX73359.1 - 9.2 6.1 5.8 1 9.2 0.2 2.3 2 0 0 2 2 2 0 U1 zinc finger KleE PF17394.2 ORX73360.1 - 0.014 15.6 2.3 0.016 15.4 0.5 2.0 1 1 1 2 2 2 0 Uncharacterized KleE stable inheritance protein DUF4752 PF15944.5 ORX73362.1 - 0.032 14.3 0.1 0.072 13.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) TraX PF05857.11 ORX73362.1 - 0.47 10.5 6.3 0.44 10.6 4.3 2.0 1 1 1 2 2 2 0 TraX protein Aconitase PF00330.20 ORX73363.1 - 7.7e-117 391.1 2.8 6.1e-70 236.5 0.4 3.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX73363.1 - 8.2e-36 123.2 0.0 1.5e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 ORX73363.1 - 0.0077 15.0 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DnaJ PF00226.31 ORX73364.1 - 4.7e-18 65.1 1.2 2.1e-17 63.0 1.2 2.2 1 0 0 1 1 1 1 DnaJ domain Aha1_N PF09229.11 ORX73365.1 - 1.5e-34 119.2 0.1 2.3e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 ORX73365.1 - 3.4e-20 72.5 0.4 6.7e-20 71.6 0.4 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ORX73365.1 - 0.0037 17.6 2.0 0.0037 17.6 2.0 2.6 3 0 0 3 3 3 1 Polyketide cyclase / dehydrase and lipid transport FLgD_tudor PF13861.6 ORX73365.1 - 0.12 12.7 0.1 0.41 10.9 0.1 2.0 1 0 0 1 1 1 0 FlgD Tudor-like domain ABC_tran PF00005.27 ORX73367.1 - 6.1e-25 88.3 0.2 1.1e-24 87.5 0.2 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 ORX73367.1 - 6.9e-17 61.6 15.2 6.9e-17 61.6 15.2 1.7 2 0 0 2 2 2 1 ABC-2 type transporter RsgA_GTPase PF03193.16 ORX73367.1 - 4.2e-06 26.8 0.0 1.3e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 ORX73367.1 - 1.4e-05 24.7 0.3 7.5e-05 22.4 0.5 2.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX73367.1 - 0.00086 19.1 0.5 0.0014 18.3 0.5 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX73367.1 - 0.0042 17.5 0.1 0.0071 16.7 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX73367.1 - 0.0074 16.4 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 ORX73367.1 - 0.014 15.7 0.1 0.023 14.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX73367.1 - 0.018 15.3 0.2 0.042 14.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX73367.1 - 0.023 14.6 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Dynamin_N PF00350.23 ORX73367.1 - 0.032 14.3 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_33 PF13671.6 ORX73367.1 - 0.038 14.2 0.1 0.068 13.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX73367.1 - 0.044 13.8 0.2 0.085 12.9 0.2 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SMC_N PF02463.19 ORX73367.1 - 0.047 13.1 0.7 0.68 9.3 0.0 2.2 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 ORX73367.1 - 0.08 12.5 0.2 0.14 11.8 0.2 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ORX73367.1 - 0.095 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX73367.1 - 0.16 12.5 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pyr_redox_2 PF07992.14 ORX73368.1 - 3.2e-67 226.8 4.5 5.3e-67 226.1 4.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX73368.1 - 9.2e-43 145.0 0.1 2.2e-42 143.7 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ORX73368.1 - 3.6e-22 78.7 5.9 6.4e-19 68.3 0.7 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX73368.1 - 5.5e-11 42.3 3.5 1.6e-07 30.9 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX73368.1 - 2.3e-09 36.9 1.9 2.3e-09 36.9 1.9 2.7 2 2 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 ORX73368.1 - 2.6e-09 36.9 0.6 2.6e-09 36.9 0.6 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX73368.1 - 2.9e-08 32.8 11.5 9.5e-05 21.3 0.5 4.1 3 1 1 4 4 4 4 HI0933-like protein FAD_binding_2 PF00890.24 ORX73368.1 - 4.5e-08 32.6 10.3 8.3e-07 28.4 0.8 4.2 4 1 1 5 5 5 1 FAD binding domain NAD_binding_8 PF13450.6 ORX73368.1 - 4.9e-08 33.1 1.6 4.8e-05 23.5 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 ORX73368.1 - 2.3e-07 30.3 3.5 0.0039 16.5 0.4 3.3 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ORX73368.1 - 2.8e-05 23.5 0.9 0.0025 17.1 0.0 2.5 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 ORX73368.1 - 4.7e-05 22.7 0.2 0.043 12.9 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 ORX73368.1 - 0.00011 21.5 7.6 0.036 13.3 0.1 3.7 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 ORX73368.1 - 0.001 18.7 14.2 0.53 9.8 0.3 4.1 3 1 1 4 4 4 2 FAD dependent oxidoreductase 3HCDH_N PF02737.18 ORX73368.1 - 0.025 14.5 0.4 0.025 14.5 0.4 2.3 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AICARFT_IMPCHas PF01808.18 ORX73369.1 - 1.4e-88 297.2 0.0 1.2e-87 294.1 0.0 2.1 2 0 0 2 2 2 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ORX73369.1 - 2.9e-25 88.3 0.0 6.2e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain DUF4419 PF14388.6 ORX73370.1 - 5.5e-07 29.3 1.1 0.00065 19.2 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4419) TIG PF01833.24 ORX73371.1 - 2.2e-11 43.7 0.3 1.7e-10 40.8 0.1 2.6 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 ORX73371.1 - 8.3e-09 35.9 0.0 1.7e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX73371.1 - 7.7e-08 32.5 0.3 2.1e-06 27.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX73371.1 - 1.2e-06 29.0 0.1 4.8e-06 27.0 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ORX73371.1 - 7.9e-05 22.9 1.5 0.003 17.9 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ORX73371.1 - 0.00026 21.2 0.1 0.1 13.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat DUF1451 PF07295.11 ORX73371.1 - 1.6 8.7 6.6 0.37 10.8 0.3 2.9 4 0 0 4 4 4 0 Zinc-ribbon containing domain Aminotran_5 PF00266.19 ORX73372.1 - 4.2e-30 104.9 0.0 5.5e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.19 ORX73372.1 - 3.8e-06 27.0 1.2 7.8e-06 25.9 0.2 2.0 3 0 0 3 3 3 1 B12 binding domain ATP-synt_C PF00137.21 ORX73373.1 - 4.7e-34 116.5 35.7 9.1e-22 77.2 14.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Man-6-P_recep PF02157.15 ORX73373.1 - 1.7 7.6 2.8 1 8.4 0.1 1.8 2 0 0 2 2 2 0 Mannose-6-phosphate receptor AAA_2 PF07724.14 ORX73374.1 - 1.3e-23 83.9 0.0 5.3e-20 72.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 ORX73374.1 - 2e-12 47.0 0.1 4.4e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 ORX73374.1 - 1.4e-05 25.5 0.0 3.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ORX73375.1 - 3.1e-46 157.3 0.0 5.3e-46 156.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX73375.1 - 1.1e-23 83.7 0.0 1.5e-22 80.0 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX73375.1 - 2.8e-19 69.1 0.0 6.9e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX73375.1 - 2e-08 34.4 0.1 5.1e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ssDNA-exonuc_C PF10141.9 ORX73375.1 - 0.022 14.4 0.1 0.063 12.9 0.1 1.8 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Band_7 PF01145.25 ORX73376.1 - 3.6e-21 76.0 3.1 6.4e-21 75.2 3.1 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family NuiA PF07924.11 ORX73377.1 - 0.014 15.8 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein ATP-sulfurylase PF01747.17 ORX73378.1 - 1.8e-67 226.9 0.0 2.3e-65 220.1 0.0 2.1 1 1 1 2 2 2 2 ATP-sulfurylase PUA_2 PF14306.6 ORX73378.1 - 3.4e-38 130.8 0.0 1.2e-28 99.8 0.0 2.3 1 1 1 2 2 2 2 PUA-like domain APS_kinase PF01583.20 ORX73378.1 - 1.6e-25 89.9 0.5 1.1e-23 83.9 0.5 3.0 1 1 0 1 1 1 1 Adenylylsulphate kinase adh_short PF00106.25 ORX73379.1 - 1.1e-32 113.2 0.1 1.2e-31 109.7 0.1 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73379.1 - 9.1e-23 81.0 0.0 8e-22 77.9 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX73379.1 - 0.00011 22.2 0.0 0.0002 21.3 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX73379.1 - 0.013 15.0 0.1 0.042 13.3 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Baculo_LEF-11 PF06385.12 ORX73379.1 - 0.017 15.6 0.0 0.084 13.4 0.0 2.2 2 0 0 2 2 2 0 Baculovirus LEF-11 protein POT1PC PF16686.5 ORX73380.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 ssDNA-binding domain of telomere protection protein RNase_HII PF01351.18 ORX73381.1 - 4.3e-57 193.2 0.0 5.1e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII RRM_1 PF00076.22 ORX73382.1 - 1.7e-14 53.4 0.0 2.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX73382.1 - 1.3e-05 24.8 0.0 1.9e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DER1 PF04511.15 ORX73383.1 - 1.8e-54 184.6 8.0 2e-54 184.4 8.0 1.0 1 0 0 1 1 1 1 Der1-like family TPR_19 PF14559.6 ORX73384.1 - 0.00032 21.1 9.1 0.13 12.8 0.4 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX73384.1 - 0.0086 16.3 5.1 1.3 9.3 0.3 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ORX73384.1 - 0.11 12.7 2.6 50 4.4 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX73384.1 - 1.2 10.0 9.7 2.8 8.7 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX73384.1 - 3.9 7.8 7.5 18 5.7 0.5 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Med9 PF07544.13 ORX73385.1 - 3.6e-07 30.2 0.6 4.8e-07 29.8 0.6 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 ORX73385.1 - 0.00058 20.1 2.9 0.0007 19.9 2.9 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex WXG100 PF06013.12 ORX73385.1 - 0.00099 19.3 4.1 0.0042 17.3 4.1 1.9 1 1 0 1 1 1 1 Proteins of 100 residues with WXG FapA PF03961.13 ORX73385.1 - 0.001 17.8 1.4 0.001 17.8 1.4 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A GAS PF13851.6 ORX73385.1 - 0.0033 16.8 3.7 0.0041 16.5 3.7 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding T4SS PF07996.11 ORX73385.1 - 0.0056 17.1 4.9 0.84 10.0 0.6 2.1 2 0 0 2 2 2 2 Type IV secretion system proteins Syntaxin_2 PF14523.6 ORX73385.1 - 0.011 16.0 0.4 0.019 15.3 0.4 1.5 1 0 0 1 1 1 0 Syntaxin-like protein TPR_MLP1_2 PF07926.12 ORX73385.1 - 0.011 15.7 3.6 0.7 10.0 1.1 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Prefoldin_2 PF01920.20 ORX73385.1 - 0.019 14.9 6.2 0.96 9.4 0.2 2.2 1 1 1 2 2 2 0 Prefoldin subunit OmpH PF03938.14 ORX73385.1 - 0.02 15.2 3.5 0.028 14.8 3.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 ORX73385.1 - 0.024 13.5 3.9 0.029 13.3 3.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FlxA PF14282.6 ORX73385.1 - 0.026 14.5 5.3 0.035 14.1 5.3 1.3 1 0 0 1 1 1 0 FlxA-like protein Tropomyosin_1 PF12718.7 ORX73385.1 - 0.029 14.5 5.1 0.048 13.8 5.1 1.3 1 0 0 1 1 1 0 Tropomyosin like I_LWEQ PF01608.17 ORX73385.1 - 0.033 14.4 2.1 0.043 14.1 2.1 1.1 1 0 0 1 1 1 0 I/LWEQ domain Fzo_mitofusin PF04799.13 ORX73385.1 - 0.066 12.8 3.2 0.11 12.1 3.2 1.3 1 1 0 1 1 1 0 fzo-like conserved region STELLO PF03385.17 ORX73385.1 - 0.085 11.7 0.0 0.087 11.6 0.0 1.1 1 0 0 1 1 1 0 STELLO glycosyltransferases NPV_P10 PF05531.12 ORX73385.1 - 0.085 13.3 4.2 0.22 12.0 0.5 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4200 PF13863.6 ORX73385.1 - 0.17 12.3 5.6 4.6 7.7 4.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MctB PF11382.8 ORX73385.1 - 0.34 10.6 3.6 1 9.0 3.6 1.8 1 1 0 1 1 1 0 Copper transport outer membrane protein, MctB YabA PF06156.13 ORX73385.1 - 2.2 9.0 4.9 8.9 7.0 4.9 1.8 1 1 0 1 1 1 0 Initiation control protein YabA SHNi-TPR PF10516.9 ORX73386.1 - 9.4e-12 44.2 0.2 2.4e-11 42.9 0.2 1.8 1 0 0 1 1 1 1 SHNi-TPR TPR_12 PF13424.6 ORX73386.1 - 2.4e-10 40.5 10.1 2.2e-05 24.7 1.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73386.1 - 8.4e-06 25.5 5.0 0.47 10.7 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73386.1 - 0.025 14.4 4.1 19 5.3 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF5076 PF16826.5 ORX73386.1 - 0.095 12.6 2.2 0.2 11.6 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5076) ANAPC3 PF12895.7 ORX73386.1 - 0.12 12.6 1.8 38 4.6 0.0 3.4 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ORX73386.1 - 0.14 12.0 3.9 7 6.7 0.0 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX73386.1 - 0.21 11.7 1.4 7.4 6.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX73386.1 - 0.86 10.0 3.9 3.1 8.2 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX73386.1 - 3.1 8.6 8.0 6.4 7.6 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Pico_P2A PF00947.19 ORX73387.1 - 0.036 14.1 0.1 0.049 13.7 0.1 1.1 1 0 0 1 1 1 0 Picornavirus core protein 2A Arginosuc_synth PF00764.19 ORX73388.1 - 3e-143 477.8 0.0 3.7e-143 477.5 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 ORX73388.1 - 0.0007 19.1 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ORX73388.1 - 0.012 14.5 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase NAT PF04768.13 ORX73390.1 - 2.5e-28 98.9 0.2 2e-27 95.9 0.1 2.4 2 1 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 ORX73390.1 - 3e-28 98.7 0.0 6.8e-28 97.5 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 ORX73390.1 - 3.6e-26 92.2 0.1 6.2e-26 91.5 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 ORX73390.1 - 1.2e-05 25.5 0.0 2.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 ORX73390.1 - 0.0083 16.2 0.0 0.028 14.5 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus MFS_1 PF07690.16 ORX73391.1 - 1.5e-26 93.2 32.8 3e-26 92.2 29.6 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Halogen_Hydrol PF10112.9 ORX73391.1 - 0.79 9.7 0.0 0.79 9.7 0.0 2.9 4 0 0 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein MFS_1 PF07690.16 ORX73392.1 - 2e-23 82.9 17.0 3.9e-23 82.0 17.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 ORX73393.1 - 3.4e-17 62.4 32.8 2.6e-16 59.5 30.4 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily CclA_1 PF16942.5 ORX73393.1 - 0.19 12.0 2.4 0.32 11.3 1.1 2.0 2 0 0 2 2 2 0 Putative cyclic bacteriocin DUF4131 PF13567.6 ORX73393.1 - 4.1 7.0 4.7 5.3 6.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Transgly_assoc PF04226.13 ORX73393.1 - 9.5 6.6 7.9 14 6.1 1.1 3.1 3 0 0 3 3 3 0 Transglycosylase associated protein Ribosomal_S13 PF00416.22 ORX73394.1 - 4.9e-22 78.7 0.2 3.8e-20 72.6 0.2 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX73394.1 - 0.00018 20.4 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_5 PF14520.6 ORX73394.1 - 0.059 14.0 0.0 0.24 12.0 0.0 2.1 2 1 1 3 3 3 0 Helix-hairpin-helix domain IMS_HHH PF11798.8 ORX73394.1 - 0.15 12.5 0.0 0.44 11.0 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif HHH PF00633.23 ORX73394.1 - 0.3 11.0 1.5 0.45 10.5 0.0 2.1 3 0 0 3 3 3 0 Helix-hairpin-helix motif Metallophos PF00149.28 ORX73395.1 - 2.7e-29 103.1 0.2 3.8e-29 102.7 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 ORX73395.1 - 6.4e-20 71.2 0.0 2.9e-19 69.1 0.0 2.1 1 1 0 1 1 1 1 PPP5 TPR repeat region TPR_2 PF07719.17 ORX73395.1 - 8.3e-12 44.3 5.8 0.00016 21.5 0.1 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73395.1 - 1.2e-10 40.7 6.4 0.0003 20.5 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX73395.1 - 1.7e-08 34.0 5.1 2.7e-05 23.8 0.3 3.3 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 ORX73395.1 - 2.2e-08 33.6 3.0 0.011 15.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73395.1 - 7.6e-06 26.3 0.5 0.0096 16.7 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX73395.1 - 0.00022 21.4 2.6 0.014 15.8 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX73395.1 - 0.00022 21.3 0.9 0.0089 16.2 0.7 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX73395.1 - 0.00058 20.3 3.1 0.36 11.4 1.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX73395.1 - 0.00063 20.0 5.2 0.12 12.7 0.6 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX73395.1 - 0.0068 17.0 4.9 0.041 14.5 0.4 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX73395.1 - 0.039 14.6 12.7 0.053 14.2 0.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 ORX73395.1 - 0.073 12.0 3.7 0.2 10.5 0.5 2.1 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 Trm5_N PF18093.1 ORX73395.1 - 0.11 12.4 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 0 tRNA methyltransferase 5 N-terminal domain SLT_L PF14718.6 ORX73395.1 - 0.11 12.6 0.4 9.5 6.4 0.0 2.7 2 0 0 2 2 2 0 Soluble lytic murein transglycosylase L domain Ribosomal_L6 PF00347.23 ORX73396.1 - 3.7e-27 94.8 0.5 1.4e-14 54.5 0.0 3.1 2 1 0 2 2 2 2 Ribosomal protein L6 ECH_1 PF00378.20 ORX73398.1 - 0.00036 19.9 0.0 0.018 14.3 0.0 2.5 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase GST_N_3 PF13417.6 ORX73399.1 - 6.2e-13 49.0 0.1 1e-12 48.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX73399.1 - 1.3e-08 35.0 0.1 2.4e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX73399.1 - 3.4e-08 33.7 0.0 7.6e-08 32.6 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX73399.1 - 0.0033 17.4 0.0 0.0053 16.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 ORX73400.1 - 6.1e-12 45.1 4.5 6.7e-12 45.0 4.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Peptidase_M36 PF02128.15 ORX73401.1 - 3.7e-136 454.1 6.1 1e-135 452.7 6.1 1.6 1 1 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX73401.1 - 0.00016 21.4 5.4 0.00077 19.2 2.3 3.3 2 1 0 2 2 2 1 Fungalysin/Thermolysin Propeptide Motif Retrotrans_gag PF03732.17 ORX73402.1 - 0.0016 18.7 0.0 0.0038 17.5 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein Transferase PF02458.15 ORX73403.1 - 1.8e-09 36.8 0.0 3.2e-05 22.8 0.0 2.3 2 1 0 2 2 2 2 Transferase family ABC_tran PF00005.27 ORX73404.1 - 9.4e-25 87.7 0.0 1.7e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX73404.1 - 1.1e-22 81.0 6.6 1.5e-22 80.5 6.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF5422 PF17459.2 ORX73404.1 - 0.0021 18.3 2.5 0.004 17.3 2.5 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5422) T2SSE PF00437.20 ORX73404.1 - 0.0034 16.5 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ORX73404.1 - 0.0097 15.4 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ORX73404.1 - 0.1 12.7 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase PDR_assoc PF08370.11 ORX73404.1 - 0.41 10.4 6.5 6.9 6.5 0.7 3.0 2 0 0 2 2 2 0 Plant PDR ABC transporter associated HBS1_N PF08938.10 ORX73534.1 - 2e-15 56.8 2.0 4.5e-15 55.7 2.0 1.5 1 0 0 1 1 1 1 HBS1 N-terminus Actin PF00022.19 ORX73535.1 - 1.4e-45 155.7 0.0 1.1e-30 106.6 0.0 2.2 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 ORX73535.1 - 4.5e-07 29.0 0.0 6e-06 25.3 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 ORX73535.1 - 0.021 15.2 0.0 0.16 12.4 0.0 2.3 2 2 0 2 2 2 0 Cell division protein FtsA PilM_2 PF11104.8 ORX73535.1 - 0.17 10.9 0.0 3.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Vac_ImportDeg PF09783.9 ORX73536.1 - 9.7e-50 168.5 0.7 1.1e-49 168.3 0.7 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein Aminotran_1_2 PF00155.21 ORX73537.1 - 4.7e-54 183.9 0.0 5.3e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ORX73537.1 - 0.0013 17.7 0.1 0.0039 16.0 0.0 1.7 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase CTU2 PF10288.9 ORX73538.1 - 3.6e-22 78.7 0.0 7.1e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 ORX73538.1 - 0.027 14.3 0.0 0.42 10.3 0.0 2.2 2 0 0 2 2 2 0 PP-loop family Trypsin_2 PF13365.6 ORX73539.1 - 9.3e-07 29.9 0.0 1.4e-06 29.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ PF00595.24 ORX73539.1 - 0.00087 19.6 0.0 0.0047 17.3 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Peptidase_S3 PF00944.19 ORX73539.1 - 0.031 14.1 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Glyco_hydro_18 PF00704.28 ORX73540.1 - 1.6e-18 67.5 0.8 1.9e-18 67.3 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CAF1A PF12253.8 ORX73541.1 - 1.7e-22 79.3 12.2 1.7e-22 79.3 12.2 3.2 2 1 1 3 3 3 1 Chromatin assembly factor 1 subunit A CDC45 PF02724.14 ORX73541.1 - 3.5 5.8 14.2 7.6 4.7 14.2 1.5 1 0 0 1 1 1 0 CDC45-like protein PHF5 PF03660.14 ORX73542.1 - 1.5e-32 111.9 6.0 2.1e-27 95.4 4.7 2.0 1 1 1 2 2 2 2 PHF5-like protein PolC_DP2 PF03833.13 ORX73542.1 - 0.0028 15.6 0.9 0.0029 15.6 0.9 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 zf-C4_ClpX PF06689.13 ORX73542.1 - 0.074 12.9 7.8 0.33 10.9 0.3 2.5 2 1 0 2 2 2 0 ClpX C4-type zinc finger DUF2039 PF10217.9 ORX73542.1 - 0.3 11.4 6.1 0.19 12.1 1.8 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) Tnp_zf-ribbon_2 PF13842.6 ORX73542.1 - 0.31 11.9 6.6 3.5 8.5 2.7 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon C1_2 PF03107.16 ORX73542.1 - 0.95 9.8 9.8 0.49 10.8 3.4 2.3 1 1 1 2 2 2 0 C1 domain Kinesin PF00225.23 ORX73543.1 - 1.3e-105 353.0 0.0 2.8e-105 351.9 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX73543.1 - 3.3e-56 189.4 0.0 3.3e-56 189.4 0.0 2.2 3 0 0 3 3 3 1 Microtubule binding DUF4200 PF13863.6 ORX73543.1 - 0.00022 21.6 21.0 0.00022 21.6 21.0 3.3 1 1 1 3 3 3 1 Domain of unknown function (DUF4200) AAA_16 PF13191.6 ORX73543.1 - 0.11 12.9 0.0 0.11 12.9 0.0 3.2 2 2 1 3 3 3 0 AAA ATPase domain ZnuA PF01297.17 ORX73543.1 - 0.2 11.1 9.4 0.087 12.2 4.6 2.2 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic DUF4407 PF14362.6 ORX73543.1 - 0.25 10.6 25.4 0.31 10.4 24.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 ORX73543.1 - 0.72 10.5 23.4 67 4.2 5.4 5.7 4 1 2 6 6 6 0 Initiation control protein YabA AbiH PF14253.6 ORX73543.1 - 3 7.6 6.1 5.4 6.8 6.1 1.4 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH FAM76 PF16046.5 ORX73543.1 - 3.4 7.0 28.6 4 6.7 6.1 2.4 1 1 1 2 2 2 0 FAM76 protein AAA_13 PF13166.6 ORX73543.1 - 3.5 6.2 25.2 0.56 8.8 17.3 1.8 1 1 1 2 2 2 0 AAA domain zinc_ribbon_9 PF14369.6 ORX73544.1 - 0.038 14.3 0.7 5.7 7.3 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon Glyco_hydro_16 PF00722.21 ORX73545.1 - 6.3e-21 74.6 0.6 1e-20 73.9 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 YukD PF08817.10 ORX73545.1 - 0.13 13.0 0.0 1 10.1 0.0 2.1 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD AMP-binding PF00501.28 ORX73547.1 - 2.6e-11 42.8 0.0 3.3e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Peptidase_M22 PF00814.25 ORX73548.1 - 7.1e-52 176.8 0.0 9.4e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Troponin-I_N PF11636.8 ORX73548.1 - 0.079 12.9 0.2 0.27 11.2 0.2 1.9 1 0 0 1 1 1 0 Troponin I residues 1-32 MA-Mit PF09245.10 ORX73549.1 - 0.064 12.7 0.8 0.1 12.1 0.8 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen SNARE PF05739.19 ORX73549.1 - 0.12 12.4 0.3 0.31 11.1 0.3 1.7 1 0 0 1 1 1 0 SNARE domain BET PF17035.5 ORX73549.1 - 0.21 11.8 0.2 0.21 11.8 0.2 3.0 3 1 1 4 4 4 0 Bromodomain extra-terminal - transcription regulation IF4E PF01652.18 ORX73550.1 - 1.1e-47 161.7 0.0 1.3e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ntox22 PF15527.6 ORX73553.1 - 0.029 14.4 0.0 0.036 14.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 22 Leader_Trp PF08255.11 ORX73553.1 - 0.53 10.4 4.8 1.2 9.3 4.8 1.6 1 0 0 1 1 1 0 Trp-operon Leader Peptide HAT_KAT11 PF08214.11 ORX73554.1 - 3.9e-30 105.3 0.0 5e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Histone acetylation protein Osmo_MPGsynth PF09488.10 ORX73554.1 - 0.12 11.0 0.1 0.15 10.7 0.1 1.1 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) Mt_ATP-synt_D PF05873.12 ORX73555.1 - 4.3e-10 39.6 4.4 1e-08 35.2 4.1 2.4 1 1 1 2 2 2 1 ATP synthase D chain, mitochondrial (ATP5H) Cytochrom_B562 PF07361.11 ORX73555.1 - 0.031 14.9 2.4 0.038 14.7 1.3 1.7 1 1 1 2 2 2 0 Cytochrome b562 NAF PF03822.14 ORX73555.1 - 0.17 12.1 0.8 39 4.5 0.0 3.0 3 0 0 3 3 3 0 NAF domain Glyco_hydro_16 PF00722.21 ORX73556.1 - 2.3e-28 98.9 3.5 2.3e-28 98.9 3.5 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 HSF_DNA-bind PF00447.17 ORX73558.1 - 1.7e-14 54.2 0.1 2.2e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 HSF-type DNA-binding Methyltransf_8 PF05148.15 ORX73558.1 - 0.0072 16.2 0.0 0.0081 16.0 0.0 1.1 1 0 0 1 1 1 1 Hypothetical methyltransferase OPT PF03169.15 ORX73559.1 - 5.9e-109 365.4 35.7 4.6e-62 210.5 10.7 3.0 1 1 2 3 3 3 3 OPT oligopeptide transporter protein VESA1_N PF12785.7 ORX73559.1 - 0.36 9.7 0.3 0.53 9.2 0.3 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 TBPIP PF07106.13 ORX73560.1 - 1.2e-15 57.2 0.0 2.4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 ORX73560.1 - 4.7e-14 52.2 0.4 4.7e-14 52.2 0.4 1.9 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Med15_fungi PF05397.12 ORX73560.1 - 0.04 14.2 1.1 0.04 14.2 1.1 2.1 2 0 0 2 2 2 0 Mediator complex subunit 15 PhetRS_B1 PF18262.1 ORX73560.1 - 0.12 12.6 1.0 0.36 11.1 0.0 2.2 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain Amidase_6 PF12671.7 ORX73560.1 - 0.16 12.1 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative amidase domain FapA PF03961.13 ORX73560.1 - 0.21 10.2 7.6 0.28 9.8 7.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PilJ PF13675.6 ORX73560.1 - 0.21 11.6 3.7 0.19 11.8 0.6 2.1 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term FUSC PF04632.12 ORX73560.1 - 0.5 8.8 1.2 0.55 8.7 1.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TEX13 PF15186.6 ORX73560.1 - 0.91 9.2 8.0 0.85 9.3 7.0 1.5 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family Atg14 PF10186.9 ORX73560.1 - 1.5 7.8 6.3 2.1 7.4 6.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 ORX73560.1 - 4.2 5.2 6.1 4.9 4.9 6.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1840 PF08895.11 ORX73560.1 - 4.4 7.7 8.9 7.2 7.0 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) TMPIT PF07851.13 ORX73560.1 - 9 5.4 8.5 8.5 5.5 7.0 1.5 1 1 1 2 2 2 0 TMPIT-like protein OTU PF02338.19 ORX73561.1 - 3e-28 98.9 1.7 3.1e-28 98.8 0.1 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ORX73561.1 - 3.8e-08 33.1 2.1 1e-05 25.1 0.0 2.8 1 1 1 2 2 2 2 Peptidase C65 Otubain DUF4407 PF14362.6 ORX73561.1 - 0.4 10.0 12.7 0.61 9.4 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 ORX73561.1 - 0.44 10.7 2.1 0.57 10.3 2.1 1.2 1 0 0 1 1 1 0 DDHD domain CAF1 PF04857.20 ORX73561.1 - 0.5 9.5 2.6 0.69 9.0 2.6 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease FTCD_C PF04961.12 ORX73561.1 - 1.2 8.9 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase FlxA PF14282.6 ORX73561.1 - 1.3 9.1 14.2 0.087 12.8 0.8 2.3 1 1 1 2 2 2 0 FlxA-like protein Aldedh PF00171.22 ORX73561.1 - 9.2 4.6 10.3 0.87 8.0 0.0 2.1 1 1 1 2 2 2 0 Aldehyde dehydrogenase family Med16 PF11635.8 ORX73562.1 - 3.2e-05 22.1 0.0 0.025 12.5 0.0 2.3 2 0 0 2 2 2 2 Mediator complex subunit 16 Myc_N PF01056.18 ORX73562.1 - 0.84 9.5 5.3 2.4 8.0 2.3 2.5 2 0 0 2 2 2 0 Myc amino-terminal region DUF4164 PF13747.6 ORX73563.1 - 0.78 10.1 4.5 0.46 10.8 2.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) NmrA PF05368.13 ORX73564.1 - 0.00016 21.3 0.0 0.00042 19.9 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family GFO_IDH_MocA PF01408.22 ORX73565.1 - 4.1e-26 92.2 0.4 6.3e-26 91.6 0.4 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ORX73565.1 - 2.3e-09 37.3 0.0 4.2e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ORX73565.1 - 3e-06 27.9 0.2 5.1e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ORX73565.1 - 0.0033 17.8 0.0 0.0062 17.0 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX73565.1 - 0.087 12.9 0.2 0.16 12.1 0.2 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CoA_binding_2 PF13380.6 ORX73565.1 - 0.089 13.3 0.2 0.19 12.2 0.2 1.5 1 0 0 1 1 1 0 CoA binding domain SPRY PF00622.28 ORX73566.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 SPRY domain Rif1_N PF12231.8 ORX73566.1 - 0.18 10.8 0.1 0.24 10.4 0.1 1.1 1 0 0 1 1 1 0 Rap1-interacting factor 1 N terminal adh_short_C2 PF13561.6 ORX73567.1 - 4.4e-24 85.3 0.0 5.4e-22 78.5 0.0 2.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX73567.1 - 3.4e-21 75.6 0.0 4.9e-20 71.8 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase tRNA-synt_1e PF01406.19 ORX73569.1 - 7.4e-108 360.5 0.2 3.5e-107 358.3 0.0 1.9 1 1 1 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ORX73569.1 - 0.00045 19.1 0.0 0.00097 18.0 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX73569.1 - 0.00062 18.2 0.0 0.0014 17.0 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 ORX73569.1 - 0.0015 17.5 1.0 0.19 10.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain ATP-synt_Eps PF04627.13 ORX73570.1 - 2.1e-19 69.2 2.6 2.5e-19 69.0 2.6 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain SRA1 PF07304.11 ORX73570.1 - 0.12 12.1 0.0 0.14 12.0 0.0 1.0 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Mito_carr PF00153.27 ORX73571.1 - 2.4e-53 178.0 8.0 4.4e-22 77.8 0.1 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein SOBP PF15279.6 ORX73572.1 - 0.71 10.4 28.2 1.3 9.6 28.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein VCPO_N PF17897.1 ORX73573.1 - 0.028 14.2 0.4 0.14 12.0 0.1 2.0 1 1 0 2 2 2 0 Vanadium chloroperoxidase N-terminal domain DUF3558 PF12079.8 ORX73573.1 - 0.24 11.4 6.0 0.41 10.6 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) Herpes_pp85 PF04637.12 ORX73573.1 - 2.8 6.2 6.4 3.8 5.8 6.4 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) 7tm_3 PF00003.22 ORX73574.1 - 0.00016 21.5 14.8 0.00023 21.0 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Mucin PF01456.17 ORX73574.1 - 0.094 12.7 7.0 0.16 12.0 7.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4834 PF16118.5 ORX73574.1 - 2.2 9.3 6.9 12 7.0 6.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) adh_short_C2 PF13561.6 ORX73575.1 - 1.5e-46 158.9 0.0 2.9e-46 157.9 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX73575.1 - 7e-41 139.8 0.0 1e-40 139.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX73575.1 - 1e-08 35.3 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX73575.1 - 0.0011 18.3 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ORX73575.1 - 0.0023 17.4 0.1 0.0059 16.0 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX73575.1 - 0.035 13.6 0.1 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family TFIIB PF00382.19 ORX73575.1 - 0.085 12.9 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Alk_phosphatase PF00245.20 ORX73578.1 - 3.7e-100 335.8 0.1 4.3e-100 335.6 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX73578.1 - 2.7e-05 23.7 0.0 0.00016 21.1 0.0 2.0 2 0 0 2 2 2 1 Metalloenzyme superfamily Alk_phosphatase PF00245.20 ORX73579.1 - 3.1e-101 339.3 0.4 3.6e-101 339.1 0.4 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX73579.1 - 0.00013 21.4 0.1 0.0003 20.2 0.1 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily Complex1_LYR PF05347.15 ORX73581.1 - 3.6e-15 55.7 2.2 6.1e-15 55.0 2.2 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX73581.1 - 9.2e-06 26.3 0.6 1e-05 26.2 0.6 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Exo_endo_phos PF03372.23 ORX73582.1 - 2.8e-05 23.8 0.1 3.5e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SAM_2 PF07647.17 ORX73583.1 - 2e-07 31.0 0.0 2.8e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX73583.1 - 1.2e-06 28.8 0.0 1.8e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ORX73583.1 - 0.0065 16.4 0.1 0.014 15.4 0.0 1.6 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Scs3p PF10261.9 ORX73584.1 - 3.7e-27 95.4 11.5 7.1e-23 81.4 1.5 2.3 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 ORX73584.1 - 0.034 13.9 5.3 0.041 13.6 5.3 1.1 1 0 0 1 1 1 0 PAP2 superfamily Alpha-amylase_C PF02806.18 ORX73585.1 - 4.5e-26 91.1 0.1 1.2e-25 89.7 0.1 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ORX73585.1 - 2.4e-20 72.6 0.1 5.6e-20 71.5 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ORX73585.1 - 6.1e-14 52.3 0.1 8.9e-08 32.1 0.0 2.2 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Thg1 PF04446.12 ORX73586.1 - 1.2e-51 173.9 0.4 1.5e-51 173.6 0.4 1.1 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 ORX73586.1 - 4.7e-20 72.0 0.3 8.2e-20 71.2 0.3 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain PALP PF00291.25 ORX73587.1 - 2.6e-50 171.5 3.8 8.7e-50 169.8 3.7 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MDM10 PF12519.8 ORX73588.1 - 5.9e-53 180.4 2.3 3.5e-47 161.3 0.5 3.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ORX73588.1 - 0.0062 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic porin Glyco_transf_21 PF13506.6 ORX73589.1 - 3.3e-39 134.1 0.2 5.2e-39 133.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 ORX73589.1 - 1.4e-26 93.8 0.0 2.5e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Ribosomal_S2 PF00318.20 ORX73589.1 - 3.3e-22 78.8 0.1 4.6e-11 42.4 0.1 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 ORX73589.1 - 1.1e-07 33.0 15.3 2.3e-07 32.1 15.3 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Glycos_transf_2 PF00535.26 ORX73589.1 - 8.5e-07 28.9 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 ORX73589.1 - 3.4e-05 23.8 7.6 6e-05 23.0 7.6 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 zf-CCCH PF00642.24 ORX73590.1 - 1.1e-08 34.7 1.6 2.6e-08 33.6 1.6 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 ORX73590.1 - 6.5e-06 25.9 5.4 1.3e-05 25.0 5.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX73590.1 - 1e-05 25.4 8.6 1.8e-05 24.6 8.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX73590.1 - 2e-05 24.5 9.5 4e-05 23.5 9.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 ORX73590.1 - 3.7e-05 23.6 2.6 9.5e-05 22.3 2.6 1.8 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4 PF00097.25 ORX73590.1 - 4e-05 23.4 8.9 7.7e-05 22.5 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX73590.1 - 5.8e-05 23.3 6.4 0.00011 22.5 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX73590.1 - 7.1e-05 22.6 8.4 0.00013 21.7 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 ORX73590.1 - 0.0002 21.5 2.5 0.0002 21.5 2.5 1.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 ORX73590.1 - 0.00081 19.5 7.2 0.002 18.2 7.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RanBP PF00641.18 ORX73590.1 - 0.0011 18.2 2.2 0.0011 18.2 2.2 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-CCCH_4 PF18044.1 ORX73590.1 - 0.0015 18.3 2.1 0.0015 18.3 2.1 2.0 2 0 0 2 2 2 1 CCCH-type zinc finger zf-Nse PF11789.8 ORX73590.1 - 0.0086 15.9 2.2 0.015 15.1 2.2 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 ORX73590.1 - 0.98 9.3 6.0 1.9 8.4 6.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 BRCT_3 PF18428.1 ORX73592.1 - 3.4e-12 46.3 0.1 0.00081 19.4 0.0 3.3 3 0 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX73592.1 - 1.5e-05 25.3 0.0 0.0011 19.3 0.0 2.5 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ORX73592.1 - 2.9e-05 23.9 0.0 0.00023 21.0 0.0 2.4 3 1 1 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 ORX73592.1 - 0.0079 16.6 0.0 0.096 13.1 0.0 2.6 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Reg_prop PF07494.11 ORX73593.1 - 5.5e-05 22.9 0.8 7.2 7.2 0.0 4.4 4 0 0 4 4 4 3 Two component regulator propeller RHS_repeat PF05593.14 ORX73593.1 - 0.0014 19.0 1.1 2.8 8.6 0.1 3.5 3 0 0 3 3 3 2 RHS Repeat PRK PF00485.18 ORX73595.1 - 2.3e-46 158.0 0.0 3.3e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 ORX73595.1 - 1.7e-44 151.7 0.7 4.4e-39 134.1 0.1 2.2 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase CPT PF07931.12 ORX73595.1 - 7.5e-05 22.6 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 ORX73595.1 - 0.00011 22.4 0.0 0.0005 20.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX73595.1 - 0.00065 20.3 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTP_transf_8 PF12281.8 ORX73595.1 - 0.0011 19.0 0.2 0.0021 18.1 0.1 1.5 1 1 0 1 1 1 1 Nucleotidyltransferase AAA_17 PF13207.6 ORX73595.1 - 0.0092 16.4 0.0 3.6 8.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain CoaE PF01121.20 ORX73595.1 - 0.018 14.7 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Dephospho-CoA kinase Zeta_toxin PF06414.12 ORX73595.1 - 0.048 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 ORX73595.1 - 0.051 13.3 0.0 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase MFS_1 PF07690.16 ORX73596.1 - 3.7e-11 42.5 35.8 3.7e-11 42.5 35.8 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 ORX73596.1 - 6.3e-09 34.9 24.0 6.3e-09 34.9 24.0 2.3 2 1 0 2 2 2 1 MFS/sugar transport protein WD40 PF00400.32 ORX73597.1 - 4.4e-36 122.3 1.3 1.8e-08 34.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73597.1 - 1e-12 48.1 0.9 0.014 15.6 0.1 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX73597.1 - 2.1e-09 36.8 0.4 0.021 13.8 0.0 4.0 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX73597.1 - 1.2e-06 27.5 3.5 0.074 11.7 0.1 4.0 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX73597.1 - 8.4e-05 21.5 0.0 2.3 6.9 0.0 3.3 3 1 0 3 3 3 3 Nup133 N terminal like eIF2A PF08662.11 ORX73597.1 - 0.021 14.7 0.2 0.31 10.9 0.0 2.6 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A UBM PF14377.6 ORX73597.1 - 0.16 11.5 0.2 2.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin binding region FeS_assembly_P PF01883.19 ORX73598.1 - 7.7e-13 48.4 0.1 1.6e-12 47.4 0.0 1.6 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein NepR PF18557.1 ORX73599.1 - 0.04 13.5 0.3 4.6 7.0 0.1 2.6 2 0 0 2 2 2 0 Anti-sigma factor NepR G-gamma PF00631.22 ORX73600.1 - 3.4e-19 68.6 0.0 3.6e-19 68.5 0.0 1.0 1 0 0 1 1 1 1 GGL domain Myb_CC_LHEQLE PF14379.6 ORX73600.1 - 0.12 12.1 1.3 0.16 11.7 1.3 1.2 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif EamA PF00892.20 ORX73601.1 - 4.8e-10 39.7 28.8 2.9e-08 34.0 3.3 3.3 3 1 0 3 3 3 3 EamA-like transporter family Mg_trans_NIPA PF05653.14 ORX73601.1 - 2.7 7.0 10.1 0.061 12.4 0.9 2.4 3 0 0 3 3 3 0 Magnesium transporter NIPA SQS_PSY PF00494.19 ORX73602.1 - 3.4e-43 148.1 0.9 4.5e-43 147.6 0.9 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase HSF_DNA-bind PF00447.17 ORX73603.1 - 0.02 15.5 0.0 0.027 15.1 0.0 1.4 1 1 0 1 1 1 0 HSF-type DNA-binding Proteasome PF00227.26 ORX73604.1 - 5.9e-54 182.4 0.1 1.1e-53 181.6 0.1 1.4 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX73604.1 - 1.3e-13 50.3 0.1 1.3e-13 50.3 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature adh_short PF00106.25 ORX73605.1 - 1.7e-38 132.0 0.0 2.1e-30 105.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73605.1 - 9e-28 97.4 0.0 2.5e-25 89.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX73605.1 - 6.3e-06 26.2 0.0 0.00047 20.1 0.0 2.2 2 0 0 2 2 2 1 KR domain LytR_C PF13399.6 ORX73605.1 - 0.069 14.1 0.0 23 6.1 0.0 2.7 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Pkinase PF00069.25 ORX73606.1 - 8.6e-65 218.7 0.0 1.1e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73606.1 - 4.6e-29 101.5 0.0 5.9e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX73606.1 - 2.3e-05 23.5 0.1 3.1e-05 23.1 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX73606.1 - 0.00042 19.7 0.1 0.0012 18.2 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX73606.1 - 0.00082 19.4 0.1 0.0034 17.4 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX73606.1 - 0.0054 16.1 0.0 0.096 12.0 0.0 2.0 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 ORX73606.1 - 0.015 14.9 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ORX73606.1 - 0.053 13.1 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family MFS_1 PF07690.16 ORX73607.1 - 1.2e-18 67.2 36.0 1.2e-18 67.2 36.0 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX73607.1 - 0.00087 18.3 12.5 0.00087 18.3 12.5 3.0 2 1 0 2 2 2 2 Sugar (and other) transporter DUF3094 PF11293.8 ORX73607.1 - 0.086 12.6 0.4 3.6 7.4 0.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF3573 PF12097.8 ORX73607.1 - 0.19 10.6 1.4 2.6 6.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) Med26 PF08711.11 ORX73609.1 - 7.1e-11 42.0 0.0 2e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Cu-oxidase_2 PF07731.14 ORX73610.1 - 2e-28 98.8 3.5 2e-28 98.8 3.5 2.8 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX73610.1 - 4.2e-21 75.2 2.9 2.2e-14 53.5 0.0 4.0 3 2 1 4 4 4 3 Multicopper oxidase Cu-oxidase PF00394.22 ORX73610.1 - 3.3e-08 33.8 3.1 0.0065 16.6 0.7 3.6 2 1 0 2 2 2 2 Multicopper oxidase Redoxin PF08534.10 ORX73612.1 - 5.2e-36 123.6 0.0 5.8e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ORX73612.1 - 4.2e-13 49.3 0.0 4.6e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DrsE PF02635.15 ORX73612.1 - 0.041 14.2 0.0 0.068 13.5 0.0 1.4 1 0 0 1 1 1 0 DsrE/DsrF-like family Snf7 PF03357.21 ORX73613.1 - 8.6e-16 58.0 10.0 1.1e-15 57.7 10.0 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 ORX73613.1 - 0.0019 18.2 2.0 0.0027 17.7 2.0 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway ATS PF15445.6 ORX73613.1 - 0.0024 17.4 0.4 0.0044 16.5 0.5 1.3 1 1 0 1 1 1 1 acidic terminal segments, variant surface antigen of PfEMP1 DMSP_lyase PF16867.5 ORX73613.1 - 0.093 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase DUF4037 PF13228.6 ORX73613.1 - 0.33 11.8 1.5 1.8 9.4 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4037) Aminotran_1_2 PF00155.21 ORX73614.1 - 1.6e-76 257.8 0.0 2.1e-76 257.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX73614.1 - 6.3e-08 31.5 0.0 1.1e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ORX73614.1 - 2.2e-05 23.9 0.0 3.9e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX73614.1 - 6.6e-05 22.0 0.0 0.00011 21.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DsrD PF08679.11 ORX73614.1 - 0.12 12.6 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) HGTP_anticodon PF03129.20 ORX73615.1 - 2.2e-13 50.2 0.0 7.8e-13 48.4 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ORX73615.1 - 2.9e-08 33.9 0.0 1.2e-07 31.9 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ABC_membrane PF00664.23 ORX73617.1 - 2.5e-72 243.8 23.9 5.9e-48 163.9 11.1 4.1 2 2 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ORX73617.1 - 7.8e-63 211.0 0.1 2.5e-34 118.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX73617.1 - 2.7e-12 46.6 7.7 1.9e-05 24.2 0.2 4.0 3 2 1 5 5 5 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ORX73617.1 - 9.9e-07 27.9 0.2 0.002 17.0 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA PF00004.29 ORX73617.1 - 0.00016 22.1 0.7 0.43 11.0 0.1 3.3 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ORX73617.1 - 0.00021 21.0 0.3 0.47 10.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX73617.1 - 0.00033 21.0 3.0 0.099 12.9 0.0 3.8 4 0 0 4 4 4 1 AAA domain SbcCD_C PF13558.6 ORX73617.1 - 0.0012 19.0 4.0 0.39 11.0 0.3 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ORX73617.1 - 0.0048 16.6 4.0 0.45 10.2 0.0 4.5 5 1 0 5 5 5 1 AAA domain AAA_16 PF13191.6 ORX73617.1 - 0.0068 16.8 4.2 0.19 12.1 0.1 3.3 3 1 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 ORX73617.1 - 0.015 15.0 0.0 3.8 7.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ORX73617.1 - 0.015 15.2 0.2 1.9 8.4 0.0 2.8 2 0 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 ORX73617.1 - 0.027 13.7 1.3 0.031 13.4 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 ORX73617.1 - 0.062 12.8 0.0 3 7.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 ORX73617.1 - 0.095 12.4 2.9 6.3 6.5 0.0 2.8 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 ORX73617.1 - 0.12 12.4 0.6 3.9 7.5 0.0 3.2 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ORX73617.1 - 0.19 11.0 2.4 1.6 8.0 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin DUF87 PF01935.17 ORX73617.1 - 0.21 11.6 7.6 3.3 7.8 0.7 3.7 4 1 0 4 4 4 0 Helicase HerA, central domain ECH_2 PF16113.5 ORX73617.1 - 0.22 11.0 3.9 2.3 7.6 0.0 3.0 2 1 0 3 3 3 0 Enoyl-CoA hydratase/isomerase EF-hand_1 PF00036.32 ORX73619.1 - 3.7e-44 145.0 8.0 6.6e-11 41.0 0.5 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX73619.1 - 1.8e-37 127.6 2.5 5.7e-19 68.3 0.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ORX73619.1 - 3.4e-34 116.5 9.0 7.9e-16 57.7 0.9 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ORX73619.1 - 1e-32 109.2 4.1 3.4e-09 35.9 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ORX73619.1 - 3.8e-29 98.9 7.7 2.1e-08 33.3 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ORX73619.1 - 7.2e-18 64.7 0.1 1.4e-09 38.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX73619.1 - 1.6e-12 47.3 1.1 2.5e-06 27.4 0.1 2.0 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX73619.1 - 1.2e-10 41.6 0.1 1.7e-05 25.1 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ORX73619.1 - 6.2e-07 29.5 2.9 0.00031 20.9 0.1 3.0 1 1 3 4 4 4 3 Dockerin type I domain UPF0154 PF03672.13 ORX73619.1 - 2.3e-06 27.5 0.1 0.0076 16.3 0.0 2.7 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 ORX73619.1 - 4.7e-06 27.4 0.0 0.0018 19.2 0.0 2.0 1 1 1 2 2 2 2 EF-hand domain TerB PF05099.13 ORX73619.1 - 1.5e-05 25.0 0.6 0.077 12.9 0.0 2.3 2 0 0 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 ORX73619.1 - 0.0001 22.3 0.4 1.8 8.5 0.0 3.7 1 1 3 4 4 4 2 Caleosin related protein RNA_pol_Rpb4 PF03874.16 ORX73619.1 - 0.00052 20.3 2.2 0.57 10.5 0.2 2.7 3 0 0 3 3 3 2 RNA polymerase Rpb4 DUF3349 PF11829.8 ORX73619.1 - 0.0057 17.4 0.6 7.4 7.4 0.0 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) EF-hand_14 PF17959.1 ORX73619.1 - 0.0092 16.3 0.1 4 7.9 0.0 2.5 2 1 0 2 2 2 1 EF-hand domain DUF5580 PF17743.1 ORX73619.1 - 0.026 13.1 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) dCache_2 PF08269.11 ORX73619.1 - 0.095 11.9 0.1 10 5.2 0.0 2.1 1 1 0 2 2 2 0 Cache domain SurA_N_2 PF13623.6 ORX73619.1 - 0.11 12.4 1.6 1.1 9.1 0.2 2.4 1 1 1 2 2 2 0 SurA N-terminal domain DUF1398 PF07166.11 ORX73619.1 - 0.11 12.6 0.0 7.1 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1398) MotA_activ PF09114.10 ORX73619.1 - 0.13 12.4 0.2 9.2 6.5 0.0 2.1 1 1 0 2 2 2 0 Transcription factor MotA, activation domain Syntaxin PF00804.25 ORX73619.1 - 0.14 11.8 2.7 2 8.0 0.2 2.2 2 0 0 2 2 2 0 Syntaxin Excalibur PF05901.11 ORX73619.1 - 1.1 9.9 2.9 32 5.2 0.0 3.7 4 0 0 4 4 4 0 Excalibur calcium-binding domain Got1 PF04178.12 ORX73620.1 - 2.3e-16 60.2 9.7 3.1e-16 59.8 9.7 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF973 PF06157.11 ORX73620.1 - 0.03 13.4 5.0 0.037 13.1 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF973) PAPA-1 PF04795.12 ORX73621.1 - 8.3e-15 55.4 7.9 1.3e-14 54.7 8.0 1.4 1 1 0 1 1 1 1 PAPA-1-like conserved region Phage_holin_3_6 PF07332.11 ORX73622.1 - 0.0024 17.9 9.5 0.0024 17.9 9.5 1.6 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III TcpE PF12648.7 ORX73622.1 - 1.2 9.7 6.4 59 4.3 10.1 1.8 2 0 0 2 2 2 0 TcpE family Ribosomal_S15 PF00312.22 ORX73623.1 - 7.2e-12 45.4 2.3 1.5e-11 44.4 2.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 SOAR PF16533.5 ORX73623.1 - 1.9 8.5 7.8 0.59 10.1 3.7 2.1 2 0 0 2 2 2 0 STIM1 Orai1-activating region PA26 PF04636.13 ORX73624.1 - 7.5e-14 51.5 0.1 3.5e-05 22.9 0.0 4.2 5 0 0 5 5 5 3 PA26 p53-induced protein (sestrin) Sel1 PF08238.12 ORX73626.1 - 1.3e-51 171.8 11.7 1.5e-07 31.9 0.1 7.4 8 0 0 8 8 8 7 Sel1 repeat Prok-TraM PF09228.10 ORX73626.1 - 0.11 12.9 0.3 0.44 10.9 0.2 2.1 2 0 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM Alg6_Alg8 PF03155.15 ORX73628.1 - 2.2e-155 518.4 23.5 2.4e-155 518.2 23.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF2415 PF10313.9 ORX73629.1 - 0.0074 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) EGF_CA PF07645.15 ORX73629.1 - 0.0092 16.2 0.4 0.013 15.7 0.4 1.2 1 0 0 1 1 1 1 Calcium-binding EGF domain zf-Di19 PF05605.12 ORX73629.1 - 0.021 15.1 1.7 0.038 14.3 0.3 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ORX73629.1 - 0.33 11.9 0.2 0.33 11.9 0.2 2.2 3 0 0 3 3 3 0 C2H2-type zinc finger Profilin PF00235.19 ORX73630.1 - 3.4e-42 143.7 0.1 3.8e-42 143.6 0.1 1.0 1 0 0 1 1 1 1 Profilin TPR_1 PF00515.28 ORX73631.1 - 0.03 14.1 0.0 0.093 12.6 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX73631.1 - 0.042 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_2 PF07719.17 ORX73631.1 - 0.05 13.7 0.0 0.23 11.7 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73631.1 - 0.064 14.1 0.2 0.064 14.1 0.2 4.5 4 2 2 6 6 6 0 Tetratricopeptide repeat Las1 PF04031.13 ORX73632.1 - 1.2e-48 165.1 0.5 2.1e-48 164.3 0.5 1.4 1 0 0 1 1 1 1 Las1-like MMR_HSR1_Xtn PF16897.5 ORX73633.1 - 3.6e-33 113.7 0.7 6.4e-33 112.9 0.7 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ORX73633.1 - 1.9e-16 60.2 0.0 4.1e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 ORX73633.1 - 2.1e-09 37.3 0.3 1.1e-08 35.0 0.3 2.1 1 1 0 1 1 1 1 TGS domain FeoB_N PF02421.18 ORX73633.1 - 1e-08 34.9 0.1 2.9e-08 33.4 0.0 1.8 2 1 0 2 2 2 1 Ferrous iron transport protein B MCM PF00493.23 ORX73633.1 - 0.016 14.3 0.8 0.069 12.2 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain Dynamin_N PF00350.23 ORX73633.1 - 0.019 15.0 0.4 3.7 7.6 0.4 2.4 2 0 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 ORX73633.1 - 0.073 13.5 0.0 0.14 12.6 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 ORX73633.1 - 0.089 11.8 0.2 0.26 10.2 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 ORX73633.1 - 0.19 12.0 0.3 0.49 10.6 0.3 1.7 1 0 0 1 1 1 0 AAA domain MatE PF01554.18 ORX73634.1 - 1e-24 87.0 31.4 5e-14 52.3 9.0 2.6 2 1 0 2 2 2 2 MatE DUF5392 PF17370.2 ORX73634.1 - 6.6 6.8 5.0 76 3.4 2.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5392) MatE PF01554.18 ORX73635.1 - 1.5e-23 83.2 20.7 8.2e-15 54.8 3.3 2.5 2 1 0 2 2 2 2 MatE L_HMGIC_fpl PF10242.9 ORX73635.1 - 0.0043 17.3 1.1 0.0043 17.3 1.1 2.4 2 0 0 2 2 2 1 Lipoma HMGIC fusion partner-like protein Phage_holin_2_1 PF04971.12 ORX73635.1 - 0.027 14.4 1.0 0.12 12.4 0.0 2.6 2 0 0 2 2 2 0 Bacteriophage P21 holin S Mo25 PF08569.11 ORX73636.1 - 9.3e-101 337.4 9.5 3.4e-100 335.6 9.5 1.7 1 1 0 1 1 1 1 Mo25-like DUF5456 PF17539.2 ORX73636.1 - 0.083 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5456) TPR_19 PF14559.6 ORX73637.1 - 0.0032 17.9 0.1 0.011 16.2 0.1 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73637.1 - 0.0041 16.9 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX73637.1 - 0.02 15.5 0.0 0.71 10.6 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73637.1 - 0.025 14.7 0.0 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_15 PF13429.6 ORX73637.1 - 0.03 13.5 0.1 0.036 13.3 0.1 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73637.1 - 0.086 13.7 0.0 5.9 8.0 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat Mpv17_PMP22 PF04117.12 ORX73639.1 - 0.086 13.1 3.4 0.93 9.8 0.1 2.1 2 0 0 2 2 2 0 Mpv17 / PMP22 family Ribosomal_L23 PF00276.20 ORX73640.1 - 5.4e-19 68.4 0.3 8.7e-19 67.7 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 UTP15_C PF09384.10 ORX73641.1 - 3.1e-45 153.5 0.9 3.1e-45 153.5 0.9 1.5 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 ORX73641.1 - 1.7e-25 88.8 5.5 3e-07 31.0 0.1 6.8 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73641.1 - 4.3e-09 36.5 0.0 0.13 12.5 0.0 5.1 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX73641.1 - 0.00015 20.6 0.4 0.0045 15.7 0.1 2.8 3 1 1 4 4 4 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX73641.1 - 0.0025 17.2 0.0 0.017 14.4 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain Coatomer_WDAD PF04053.14 ORX73641.1 - 0.0026 16.9 0.0 0.94 8.4 0.0 2.4 2 1 0 2 2 2 2 Coatomer WD associated region DUF5122 PF17164.4 ORX73641.1 - 0.096 13.0 0.1 0.29 11.5 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5122) beta-propeller Pkinase PF00069.25 ORX73642.1 - 1.5e-68 231.0 0.0 2.2e-68 230.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73642.1 - 2.6e-34 118.7 0.0 4.6e-34 117.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX73642.1 - 0.0013 17.8 0.0 0.0023 17.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX73642.1 - 0.0015 17.9 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX73642.1 - 0.018 14.6 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 ORX73642.1 - 0.023 14.0 1.0 0.067 12.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 ORX73642.1 - 0.1 11.4 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 ORX73642.1 - 0.17 11.5 0.1 0.17 11.5 0.1 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 CDK2AP PF09806.9 ORX73642.1 - 1.1 9.3 4.1 1.5 8.8 4.1 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Sugar_tr PF00083.24 ORX73643.1 - 1.6e-51 175.6 21.5 2e-51 175.3 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX73643.1 - 3.6e-23 82.1 22.5 1.6e-16 60.2 13.0 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX73643.1 - 4e-05 23.1 5.6 8.7e-05 22.0 5.6 1.5 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB S-methyl_trans PF02574.16 ORX73644.1 - 5.5e-51 173.9 2.4 7.9e-51 173.4 2.4 1.2 1 0 0 1 1 1 1 Homocysteine S-methyltransferase BLM10_mid PF16507.5 ORX73645.1 - 2.9e-114 382.6 0.3 2.9e-114 382.6 0.3 2.4 3 0 0 3 3 3 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 ORX73645.1 - 2.4e-36 123.5 0.5 3.3e-33 113.4 0.0 4.2 3 1 1 4 4 4 2 Domain of unknown function (DUF3437) HEAT_EZ PF13513.6 ORX73645.1 - 0.15 12.6 0.1 15 6.2 0.0 4.2 3 0 0 3 3 3 0 HEAT-like repeat HEAT PF02985.22 ORX73645.1 - 1.5 9.3 3.1 17 6.0 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat Topoisom_I PF01028.20 ORX73646.1 - 2.2e-85 285.6 3.2 7.7e-75 251.1 0.2 2.3 1 1 1 2 2 2 2 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 ORX73646.1 - 1.9e-69 233.4 0.3 8.9e-51 172.4 0.1 2.6 1 1 1 2 2 2 2 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 ORX73646.1 - 2.2e-30 104.4 1.7 2.2e-30 104.4 1.7 1.9 2 0 0 2 2 2 1 C-terminal topoisomerase domain UPF0167 PF03691.14 ORX73646.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) Ndufs5 PF10200.9 ORX73648.1 - 0.00065 19.9 0.6 0.0013 19.0 0.6 1.5 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Cmc1 PF08583.10 ORX73648.1 - 0.074 13.1 0.1 0.091 12.8 0.1 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.17 ORX73648.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.0 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb UPF0203 PF05254.12 ORX73648.1 - 0.19 12.0 4.3 0.52 10.6 3.9 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) CBF PF03914.17 ORX73649.1 - 6.8e-29 101.1 5.0 5.7e-28 98.1 3.3 2.7 2 1 0 2 2 2 1 CBF/Mak21 family Ras PF00071.22 ORX73651.1 - 1.4e-31 109.3 0.0 2.1e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX73651.1 - 8.6e-22 77.6 0.0 2e-21 76.4 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX73651.1 - 1.2e-06 28.1 0.0 2.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX73651.1 - 2.4e-05 24.4 0.0 3.9e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 ORX73651.1 - 0.0002 21.7 0.0 0.00042 20.7 0.0 1.5 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 ORX73651.1 - 0.0015 17.9 0.0 0.0024 17.3 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX73651.1 - 0.0016 18.4 0.0 0.061 13.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 ORX73651.1 - 0.0023 18.4 0.3 0.0053 17.3 0.3 1.8 1 1 0 1 1 1 1 ABC transporter G-alpha PF00503.20 ORX73651.1 - 0.0026 17.0 1.3 0.79 8.8 0.1 2.9 1 1 2 3 3 3 1 G-protein alpha subunit PduV-EutP PF10662.9 ORX73651.1 - 0.0036 17.0 0.1 0.013 15.2 0.1 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ORX73651.1 - 0.0039 17.5 0.4 0.013 15.7 0.1 1.9 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ORX73651.1 - 0.0047 16.7 0.0 0.0093 15.7 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Septin PF00735.18 ORX73651.1 - 0.0079 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 ORX73651.1 - 0.0092 16.4 0.1 0.019 15.3 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 ORX73651.1 - 0.014 15.3 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 ORX73651.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 ORX73651.1 - 0.02 14.5 0.0 0.037 13.5 0.0 1.4 2 0 0 2 2 1 0 Ferrous iron transport protein B NB-ARC PF00931.22 ORX73651.1 - 0.031 13.4 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 ORX73651.1 - 0.046 13.8 0.0 0.058 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ORX73651.1 - 0.084 12.4 0.7 3.9 7.0 0.7 2.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX73651.1 - 0.091 12.2 0.2 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit PRK PF00485.18 ORX73651.1 - 0.097 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family KAP_NTPase PF07693.14 ORX73651.1 - 0.097 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain ATP_bind_1 PF03029.17 ORX73651.1 - 0.11 12.3 0.2 27 4.4 0.0 2.8 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 ORX73651.1 - 0.11 13.0 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ORX73651.1 - 0.12 12.7 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 ORX73651.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) NTPase_1 PF03266.15 ORX73651.1 - 0.15 12.0 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 NTPase TsaE PF02367.17 ORX73651.1 - 0.15 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Transferase PF02458.15 ORX73652.1 - 7e-10 38.1 0.0 6.3e-09 35.0 0.0 2.3 2 1 0 2 2 2 1 Transferase family DUF4381 PF14316.6 ORX73653.1 - 0.012 15.9 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DLIC PF05783.11 ORX73654.1 - 0.94 8.2 2.5 1.1 8.0 2.5 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Thymidylat_synt PF00303.19 ORX73655.1 - 1.2e-96 323.0 0.0 3.4e-96 321.5 0.0 1.6 1 1 0 1 1 1 1 Thymidylate synthase Glyco_hydro_31 PF01055.26 ORX73656.1 - 3.2e-107 359.4 0.0 8.1e-59 199.9 0.0 2.4 2 1 1 3 3 3 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX73656.1 - 1.3e-22 80.1 0.0 3.1e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase DUF5110 PF17137.4 ORX73656.1 - 0.015 15.5 0.1 0.061 13.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) Gal_mutarotas_2 PF13802.6 ORX73656.1 - 1.5 9.2 4.4 0.52 10.7 0.9 2.1 2 0 0 2 2 2 0 Galactose mutarotase-like Hist_deacetyl PF00850.19 ORX73657.1 - 2.1e-68 231.1 0.0 2.3e-68 230.9 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain DUF2119 PF09892.9 ORX73657.1 - 0.18 11.2 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) CBFD_NFYB_HMF PF00808.23 ORX73658.1 - 2.7e-15 56.4 0.0 3.5e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX73658.1 - 1.7e-06 28.4 0.0 2.2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX73658.1 - 0.081 13.1 0.1 0.11 12.6 0.1 1.4 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold LRR_6 PF13516.6 ORX73659.1 - 1.9e-16 58.7 14.6 0.019 15.0 0.0 8.7 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 ORX73659.1 - 8e-10 38.8 4.6 1.1 9.8 0.0 6.9 5 2 2 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX73659.1 - 4.6e-05 23.1 12.1 0.81 9.5 0.1 6.9 7 2 0 7 7 7 1 Leucine rich repeat LRR_1 PF00560.33 ORX73659.1 - 6.9e-05 22.9 0.1 2.5e+02 2.9 0.0 6.9 8 0 0 8 8 8 0 Leucine Rich Repeat HOASN PF14515.6 ORX73659.1 - 0.19 12.1 3.5 14 6.2 0.0 3.5 2 2 1 3 3 3 0 Haem-oxygenase-associated N-terminal helices NOA36 PF06524.12 ORX73659.1 - 1.5 8.1 9.6 2.4 7.4 9.6 1.3 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 ORX73659.1 - 2.6 7.2 8.5 3.9 6.6 8.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Dynamin_M PF01031.20 ORX73660.1 - 2e-69 234.0 0.0 2.5e-38 131.9 0.0 3.0 2 1 1 3 3 3 2 Dynamin central region GED PF02212.18 ORX73660.1 - 7e-30 103.0 0.4 1.5e-29 102.0 0.4 1.6 1 0 0 1 1 1 1 Dynamin GTPase effector domain Dynamin_N PF00350.23 ORX73660.1 - 2.6e-29 102.5 0.2 4.2e-29 101.7 0.2 1.4 1 0 0 1 1 1 1 Dynamin family Pkinase PF00069.25 ORX73661.1 - 1.6e-60 204.7 0.0 2.3e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73661.1 - 6e-32 111.0 0.0 9.2e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 ORX73661.1 - 6.9e-13 48.6 0.0 1.3e-08 34.9 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region APH PF01636.23 ORX73661.1 - 6.9e-05 22.9 1.5 0.00012 22.1 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX73661.1 - 0.00025 20.0 0.0 0.00044 19.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX73661.1 - 0.00073 18.9 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX73661.1 - 0.032 13.6 0.2 0.066 12.6 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Suf PF05843.14 ORX73662.1 - 1.7e-38 133.3 1.7 1.2e-34 120.7 0.0 3.7 3 1 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ORX73662.1 - 2.9e-05 24.5 11.2 0.032 15.0 0.2 6.2 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX73662.1 - 3.2e-05 24.4 4.3 0.37 11.3 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX73662.1 - 0.016 14.5 9.7 0.21 10.8 0.5 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX73662.1 - 0.057 12.5 5.6 0.12 11.5 0.3 3.8 4 1 0 4 4 4 0 NRDE-2, necessary for RNA interference Cdh1_DBD_1 PF18196.1 ORX73662.1 - 0.1 12.9 0.3 0.36 11.1 0.3 1.9 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Peptidase_S9 PF00326.21 ORX73663.1 - 1.4e-47 161.9 0.0 2.3e-47 161.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 ORX73663.1 - 0.0023 17.8 0.6 0.086 12.8 0.0 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ORX73663.1 - 0.0098 15.5 0.0 0.43 10.1 0.0 2.3 2 0 0 2 2 2 1 PQQ-like domain Kelch_6 PF13964.6 ORX73663.1 - 0.066 13.5 0.2 2.6 8.5 0.1 3.3 3 0 0 3 3 3 0 Kelch motif Gmad1 PF10647.9 ORX73663.1 - 0.093 12.5 0.0 27 4.4 0.0 2.7 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain Sec23_trunk PF04811.15 ORX73664.1 - 1.5e-31 109.8 0.0 7.4e-21 74.8 0.0 2.6 2 0 0 2 2 2 2 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ORX73664.1 - 3.1e-22 78.3 0.1 6.2e-22 77.4 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ORX73664.1 - 8.5e-18 64.9 0.0 2e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ORX73664.1 - 9.4e-09 35.2 6.8 2.5e-08 33.8 6.8 1.8 1 1 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX73664.1 - 5.9e-05 22.9 0.0 0.00022 21.1 0.0 1.9 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ORX73664.1 - 0.072 12.5 0.2 0.16 11.4 0.2 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Lin-8 PF03353.15 ORX73664.1 - 0.25 10.8 5.3 0.4 10.2 5.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1645 PF07816.11 ORX73664.1 - 0.26 11.9 3.8 0.51 10.9 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Exo_endo_phos PF03372.23 ORX73665.1 - 1.3e-07 31.3 0.0 2.3e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family UQ_con PF00179.26 ORX73666.1 - 7.6e-49 165.0 0.0 9.8e-49 164.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX73666.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 ORX73666.1 - 0.024 14.9 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 ORX73666.1 - 0.052 13.4 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain DUF4663 PF15668.5 ORX73666.1 - 1.1 8.3 7.1 0.16 11.0 3.5 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4663) SNAP PF14938.6 ORX73667.1 - 1.5e-16 60.6 13.1 2.6e-08 33.6 0.3 2.6 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 ORX73667.1 - 0.0045 17.1 3.7 0.32 11.3 0.2 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat NSF PF02071.20 ORX73667.1 - 0.0084 16.6 11.4 1.4 10.0 0.1 5.0 4 1 1 5 5 5 1 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 ORX73667.1 - 0.015 15.4 7.3 5.1 7.5 0.0 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73667.1 - 0.025 14.4 6.2 0.59 10.1 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX73667.1 - 0.029 14.7 6.2 9.4 6.6 2.8 3.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73667.1 - 0.055 14.3 2.0 18 6.5 0.2 3.8 3 1 2 5 5 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ORX73667.1 - 0.096 13.4 3.3 3.5 8.5 0.0 4.0 3 1 1 4 4 4 0 Sel1 repeat DHR-2 PF06920.13 ORX73667.1 - 0.16 10.6 1.6 1.2 7.7 1.7 1.8 1 1 1 2 2 2 0 Dock homology region 2 MIT PF04212.18 ORX73667.1 - 0.18 11.9 3.4 0.55 10.3 0.1 2.8 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain DUF1771 PF08590.10 ORX73667.1 - 3.7 8.0 9.2 16 5.9 2.1 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1771) TPR_6 PF13174.6 ORX73667.1 - 4 8.3 5.1 63 4.5 2.3 4.0 3 1 0 3 3 2 0 Tetratricopeptide repeat Phage_tail_2 PF06199.11 ORX73668.1 - 0.12 12.5 1.9 0.12 12.4 0.4 1.6 2 0 0 2 2 2 0 Phage tail tube protein DUF4576 PF15144.6 ORX73669.1 - 0.075 12.9 1.8 0.11 12.3 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4576) FAM176 PF14851.6 ORX73669.1 - 0.2 11.3 0.4 0.23 11.1 0.4 1.1 1 0 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 ORX73669.1 - 0.56 10.1 6.7 0.61 10.0 6.7 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4148 PF13663.6 ORX73669.1 - 0.61 10.3 0.0 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Ribosomal_S6e PF01092.19 ORX73671.1 - 9.6e-58 193.6 0.1 9.6e-58 193.6 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S6e rRNA_processing PF08524.11 ORX73671.1 - 0.33 11.0 16.4 0.48 10.4 16.4 1.3 1 0 0 1 1 1 0 rRNA processing Mgm101p PF06420.12 ORX73672.1 - 1.8e-73 245.7 0.0 2.8e-73 245.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Actin PF00022.19 ORX73673.1 - 2.5e-100 335.9 0.0 1.1e-99 333.8 0.0 1.8 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 ORX73673.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3662 PF12401.8 ORX73673.1 - 0.18 12.2 0.0 0.78 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2662) Vps8 PF12816.7 ORX73674.1 - 6.3e-27 94.4 0.1 8.6e-26 90.7 0.0 2.9 4 0 0 4 4 4 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 ORX73674.1 - 8.6e-05 22.4 0.0 0.05 13.5 0.0 3.5 4 0 0 4 4 4 2 Region in Clathrin and VPS Cullin PF00888.22 ORX73675.1 - 1.5e-141 473.0 2.7 4.5e-108 362.5 0.3 3.5 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 ORX73675.1 - 3.9e-24 84.4 1.8 2e-23 82.2 0.6 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.10 ORX73675.1 - 0.034 13.9 1.4 0.89 9.4 0.1 2.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain DNA_methylase PF00145.17 ORX73675.1 - 0.087 12.2 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase GATA PF00320.27 ORX73676.1 - 0.00049 19.7 2.2 0.0009 18.8 2.2 1.5 1 0 0 1 1 1 1 GATA zinc finger LRR_8 PF13855.6 ORX73677.1 - 0.0028 17.4 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat Cnd2 PF05786.14 ORX73678.1 - 3.9e-123 412.7 13.9 1.5e-88 298.4 12.0 2.9 2 1 0 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 ORX73678.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Sec23_trunk PF04811.15 ORX73679.1 - 1.1e-52 179.1 0.0 2.8e-33 115.5 0.0 2.3 1 1 1 2 2 2 2 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ORX73679.1 - 1.3e-18 67.5 0.0 3.1e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ORX73679.1 - 2.6e-18 65.7 0.0 7e-17 61.1 0.0 2.7 1 1 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ORX73679.1 - 7.5e-17 61.1 3.1 1.4e-16 60.3 3.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX73679.1 - 3.4e-05 23.7 0.7 8.7e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Gelsolin repeat Sacchrp_dh_NADP PF03435.18 ORX73680.1 - 1.9e-06 28.2 0.1 3e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Peptidase_S9 PF00326.21 ORX73681.1 - 2.4e-19 69.7 0.0 2.6e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family DCP2 PF05026.13 ORX73682.1 - 6.4e-36 122.5 0.7 1e-35 121.9 0.7 1.3 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 ORX73682.1 - 6.9e-15 55.2 0.1 1.4e-14 54.2 0.0 1.5 2 0 0 2 2 2 1 NUDIX domain Cys_Met_Meta_PP PF01053.20 ORX73683.1 - 1.8e-154 513.9 0.0 2.1e-154 513.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX73683.1 - 1e-06 28.3 1.6 7.1e-06 25.6 1.2 2.1 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ORX73683.1 - 5.3e-06 25.9 0.1 9.4e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX73683.1 - 8.6e-05 22.0 0.6 0.00053 19.3 0.6 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX73683.1 - 0.00019 20.5 1.1 0.00023 20.2 0.1 1.5 2 0 0 2 2 2 1 Aminotransferase class-V DAO PF01266.24 ORX73684.1 - 1.9e-50 172.5 0.9 2.1e-50 172.3 0.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX73684.1 - 3e-05 24.2 0.1 7.2e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ORX73684.1 - 0.00028 20.1 0.3 0.0013 17.9 0.3 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ORX73684.1 - 0.015 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 ORX73684.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 GMC oxidoreductase Thi4 PF01946.17 ORX73684.1 - 0.033 13.4 0.0 0.062 12.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 ORX73684.1 - 0.058 12.1 0.1 0.081 11.6 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 ORX73684.1 - 0.097 12.9 0.0 0.36 11.1 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_3 PF01494.19 ORX73684.1 - 0.11 11.7 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain RIX1 PF08167.12 ORX73686.1 - 9.1e-28 97.3 1.5 1.3e-27 96.8 0.1 2.0 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Fip1 PF05182.13 ORX73688.1 - 4.1e-25 87.0 0.3 4.9e-25 86.8 0.3 1.1 1 0 0 1 1 1 1 Fip1 motif Kinesin PF00225.23 ORX73689.1 - 3.9e-92 308.7 1.3 7.5e-92 307.8 1.3 1.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX73689.1 - 7.4e-21 74.6 0.2 1.5e-20 73.6 0.2 1.5 1 0 0 1 1 1 1 Microtubule binding Bac_DnaA PF00308.18 ORX73689.1 - 0.0039 17.1 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial dnaA protein HOOK PF05622.12 ORX73690.1 - 0.0021 16.3 25.1 0.0021 16.3 25.1 4.7 1 1 4 5 5 5 2 HOOK protein Baculo_PEP_C PF04513.12 ORX73690.1 - 0.013 15.6 10.4 0.013 15.6 10.4 6.7 2 2 3 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus MAD PF05557.13 ORX73690.1 - 0.11 10.8 102.6 0.0075 14.7 26.1 3.3 1 1 2 3 3 3 0 Mitotic checkpoint protein Spc7 PF08317.11 ORX73690.1 - 0.14 11.0 115.6 0.073 11.9 15.0 6.3 1 1 6 7 7 7 0 Spc7 kinetochore protein SUIM_assoc PF16619.5 ORX73690.1 - 0.27 11.3 7.0 0.14 12.3 2.1 3.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Rab5-bind PF09311.11 ORX73690.1 - 0.79 9.0 89.8 0.056 12.8 15.7 3.4 1 1 1 3 3 3 0 Rabaptin-like protein Filament PF00038.21 ORX73690.1 - 1.9 8.0 99.5 0.079 12.5 39.0 5.3 1 1 2 3 3 3 0 Intermediate filament protein DUF4743 PF15916.5 ORX73690.1 - 2.3 8.2 7.0 7.5 6.6 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4743) DUF1664 PF07889.12 ORX73690.1 - 3 7.9 67.0 0.73 9.9 3.1 7.5 4 3 3 7 7 7 0 Protein of unknown function (DUF1664) TACC_C PF05010.14 ORX73690.1 - 6.4 6.5 88.8 0.016 15.0 12.9 5.0 2 2 1 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal AstE_AspA PF04952.14 ORX73691.1 - 8.2e-46 156.4 0.0 1.4e-45 155.6 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family SPX PF03105.19 ORX73691.1 - 2.8e-14 53.8 11.2 9.1e-07 29.1 2.0 3.1 1 1 2 3 3 3 3 SPX domain DUF1759 PF03564.15 ORX73691.1 - 0.088 12.7 0.3 0.16 11.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) WXG100 PF06013.12 ORX73691.1 - 0.46 10.7 3.7 1.3 9.3 3.7 1.7 1 1 0 1 1 1 0 Proteins of 100 residues with WXG DUF1729 PF08354.10 ORX73692.1 - 2.5e-126 421.3 0.0 4e-126 420.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX73692.1 - 4.8e-51 173.3 0.0 9.8e-51 172.3 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ORX73692.1 - 8.4e-50 170.1 0.1 2e-48 165.6 0.0 3.3 4 1 0 4 4 4 1 Acyl transferase domain FAS_I_H PF18314.1 ORX73692.1 - 8.2e-40 136.6 0.0 1.4e-39 135.8 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX73692.1 - 1.5e-23 82.7 0.0 3.5e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 ORX73692.1 - 3.6e-22 79.3 1.3 3.8e-22 79.2 0.1 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 ORX73692.1 - 8.7e-21 74.3 0.0 1.8e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ORX73692.1 - 2.1e-17 63.5 1.3 2.7e-17 63.2 0.2 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX73692.1 - 2e-14 53.6 0.0 4.9e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain FAS_N PF17828.1 ORX73692.1 - 4.6e-06 26.7 0.0 1.3e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Thiolase_N PF00108.23 ORX73692.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain PMT PF02366.18 ORX73693.1 - 4.1e-71 239.4 13.8 4.1e-71 239.4 13.8 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX73693.1 - 1.8e-52 177.8 13.1 1.8e-52 177.8 13.1 2.6 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX73693.1 - 2.8e-16 59.9 0.1 4.6e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ORX73693.1 - 0.46 10.7 15.1 0.062 13.5 5.8 2.9 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase PX PF00787.24 ORX73694.1 - 5.7e-12 45.6 0.4 7e-11 42.1 0.0 2.7 3 0 0 3 3 3 1 PX domain RA PF00788.23 ORX73695.1 - 1.7e-14 54.2 0.0 3.1e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.17 ORX73695.1 - 2.7e-12 46.6 0.0 4.4e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX73695.1 - 1.4e-08 35.1 0.0 2.2e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ORX73695.1 - 0.0042 17.0 0.0 0.0077 16.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WD40 PF00400.32 ORX73696.1 - 1.8e-10 41.2 18.5 0.012 16.5 0.5 8.1 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73696.1 - 2.7e-10 40.4 4.9 0.053 13.8 0.0 5.8 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 ORX73696.1 - 0.02 14.2 0.3 0.48 9.7 0.1 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Mcl1_mid PF12341.8 ORX73696.1 - 0.056 12.8 0.1 0.27 10.6 0.1 1.9 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region TLP1_add_C PF18313.1 ORX73696.1 - 0.1 12.6 2.1 0.68 9.9 0.1 3.2 3 0 0 3 3 3 0 Thiolase-like protein type 1 additional C-terminal domain Frtz PF11768.8 ORX73696.1 - 0.11 10.8 0.0 0.19 10.0 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ORX73696.1 - 0.11 11.2 0.0 13 4.4 0.0 2.5 2 0 0 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.6 ORX73696.1 - 0.12 12.4 0.0 7 6.7 0.0 3.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.6 ORX73696.1 - 6.3 7.4 22.1 14 6.3 0.0 6.7 8 0 0 8 8 8 0 PQQ-like domain Spt4 PF06093.13 ORX73697.1 - 3.5e-19 68.7 0.0 4.1e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Pyridoxal_deC PF00282.19 ORX73698.1 - 8e-08 31.4 0.0 1.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cnd3 PF12719.7 ORX73699.1 - 1.8e-63 214.5 1.3 4.2e-63 213.3 0.1 2.2 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 ORX73699.1 - 2.9e-10 40.4 3.7 4.6e-07 30.1 0.1 5.0 4 0 0 4 4 4 2 HEAT repeats Cnd1 PF12717.7 ORX73699.1 - 9e-06 25.8 7.5 0.00038 20.5 0.1 5.0 5 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX73699.1 - 0.00029 20.8 3.7 0.67 10.4 0.0 6.2 6 1 1 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 ORX73699.1 - 0.0039 17.7 0.6 3.9 8.1 0.2 4.8 4 1 1 5 5 5 2 HEAT-like repeat FAM176 PF14851.6 ORX73699.1 - 0.77 9.4 3.1 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 FAM176 family Sel1 PF08238.12 ORX73700.1 - 5.2e-17 61.9 15.4 1.1e-06 29.1 2.3 4.4 4 0 0 4 4 4 4 Sel1 repeat Sacchrp_dh_NADP PF03435.18 ORX73701.1 - 7.2e-10 39.2 0.1 1.1e-09 38.6 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ORX73701.1 - 0.00031 20.0 0.1 0.00048 19.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 ORX73701.1 - 0.034 14.6 0.0 0.071 13.6 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ORX73701.1 - 0.044 12.8 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ORX73701.1 - 0.052 13.4 0.5 0.16 11.9 0.4 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 ORX73701.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.10 ORX73701.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 KR domain NAD_binding_4 PF07993.12 ORX73701.1 - 0.13 11.4 0.0 0.35 10.0 0.0 1.7 2 0 0 2 2 2 0 Male sterility protein GDP_Man_Dehyd PF16363.5 ORX73701.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase FXa_inhibition PF14670.6 ORX73703.1 - 0.0041 17.4 2.3 0.007 16.6 2.3 1.4 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Ribosomal_S13_N PF08069.12 ORX73704.1 - 5.8e-30 103.1 0.1 1e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ORX73704.1 - 7.6e-13 48.5 0.2 9.3e-13 48.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 ORX73704.1 - 0.084 12.8 0.1 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 'Paired box' domain YflT PF11181.8 ORX73704.1 - 0.17 12.4 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Heat induced stress protein YflT DUF16 PF01519.16 ORX73705.1 - 0.17 12.4 3.6 0.11 13.1 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 ORX73705.1 - 3.2 8.4 8.4 0.83 10.3 0.6 3.6 4 0 0 4 4 4 0 SlyX RNase_PH PF01138.21 ORX73706.1 - 2.5e-27 96.0 0.1 4.1e-27 95.3 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 zf-LITAF-like PF10601.9 ORX73707.1 - 3.7e-09 36.7 0.6 6.8e-09 35.9 0.6 1.5 1 1 0 1 1 1 1 LITAF-like zinc ribbon domain Zn_Tnp_IS1 PF03811.13 ORX73707.1 - 0.0043 16.7 0.2 0.0043 16.7 0.2 2.3 2 0 0 2 2 2 1 InsA N-terminal domain Zn_Tnp_IS1595 PF12760.7 ORX73707.1 - 0.011 15.7 1.4 0.12 12.4 0.1 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain IF4E PF01652.18 ORX73708.1 - 8.1e-54 181.7 0.3 1e-53 181.4 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1279 PF06916.13 ORX73709.1 - 7.7e-12 45.6 0.1 1.5e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) CitMHS PF03600.16 ORX73710.1 - 0.049 12.8 2.9 0.059 12.5 2.9 1.4 1 0 0 1 1 1 0 Citrate transporter DUF5373 PF17343.2 ORX73710.1 - 0.99 9.2 9.2 1.8 8.3 9.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5373) Tetraspanin PF00335.20 ORX73710.1 - 4.6 6.9 8.3 7 6.3 8.3 1.2 1 0 0 1 1 1 0 Tetraspanin family adh_short PF00106.25 ORX73712.1 - 5.5e-42 143.4 3.2 7e-42 143.1 3.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73712.1 - 7e-26 91.2 1.8 9e-26 90.9 1.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX73712.1 - 2e-05 24.6 1.0 2.6e-05 24.2 1.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX73712.1 - 0.00013 21.5 1.5 0.00075 19.0 1.5 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX73712.1 - 0.0027 17.2 0.1 0.037 13.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 ORX73712.1 - 0.0084 15.5 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) TrkA_N PF02254.18 ORX73712.1 - 0.039 14.2 0.6 0.093 13.0 0.3 1.8 1 1 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 ORX73712.1 - 0.041 13.0 0.3 0.07 12.3 0.3 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 ORX73712.1 - 0.096 13.1 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase_fungal PF17667.1 ORX73713.1 - 7.9e-15 54.5 0.6 8.1e-15 54.5 0.6 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ORX73713.1 - 0.14 11.4 0.1 0.15 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase ribosomal_L24 PF17136.4 ORX73714.1 - 1.8e-13 50.7 0.1 3.3e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ORX73714.1 - 2.7e-07 30.3 2.6 5.4e-07 29.3 2.6 1.5 1 0 0 1 1 1 1 KOW motif Alg14 PF08660.11 ORX73715.1 - 1.9e-58 197.3 0.2 2.4e-58 197.0 0.2 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like TPR_12 PF13424.6 ORX73718.1 - 7.2e-08 32.6 16.8 0.0011 19.2 3.3 4.2 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73718.1 - 5.2e-05 23.0 19.0 0.13 12.4 2.8 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73718.1 - 6.3e-05 23.5 33.7 0.15 12.9 0.1 7.0 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX73718.1 - 0.0027 17.8 6.6 8.7 6.8 0.0 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX73718.1 - 0.0042 17.5 15.0 0.2 12.2 3.3 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX73718.1 - 0.0046 16.9 7.6 2.4 8.4 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX73718.1 - 0.0054 17.4 7.4 0.0054 17.4 7.4 6.4 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73718.1 - 0.035 13.9 9.9 3.7 7.5 2.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX73718.1 - 1.1 9.8 4.8 19 5.9 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX73718.1 - 4.8 6.9 8.6 1.6 8.5 0.1 3.5 3 1 0 3 3 3 0 TPR repeat TPR_10 PF13374.6 ORX73718.1 - 9.2 6.3 14.2 1.3 9.0 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73720.1 - 4.1e-15 54.6 5.0 0.0024 17.8 0.0 6.3 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX73720.1 - 4.2e-14 52.8 12.0 8.4e-07 29.4 0.1 4.8 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ORX73720.1 - 9e-13 48.6 0.0 1.7e-05 25.4 0.0 5.0 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX73720.1 - 6e-12 45.1 3.3 0.012 16.0 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX73720.1 - 8.7e-12 44.5 4.2 1e-06 28.3 0.0 4.5 4 1 2 6 6 6 3 TPR repeat TPR_1 PF00515.28 ORX73720.1 - 1.1e-11 44.0 2.8 0.00022 20.9 0.0 5.7 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX73720.1 - 1.4e-11 43.6 3.3 0.02 15.1 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX73720.1 - 4.1e-11 43.0 6.1 9e-05 22.7 0.1 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73720.1 - 5.8e-11 42.3 8.3 0.0082 16.9 0.3 5.9 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX73720.1 - 5.1e-09 35.5 2.5 0.077 13.1 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX73720.1 - 4.9e-06 26.8 0.2 0.85 10.4 0.0 5.0 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX73720.1 - 3.4e-05 24.1 0.1 0.25 11.7 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX73720.1 - 0.00048 19.9 1.3 14 5.7 0.2 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ORX73720.1 - 0.0084 15.4 0.5 9 5.4 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_5 PF12688.7 ORX73720.1 - 0.0089 16.3 0.3 0.027 14.7 0.1 1.9 2 0 0 2 2 2 1 Tetratrico peptide repeat TPR_9 PF13371.6 ORX73720.1 - 0.03 14.5 0.8 0.91 9.7 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX73720.1 - 0.078 13.1 0.0 8.5 6.5 0.0 2.6 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ORX73721.1 - 0.00044 20.4 1.1 0.0008 19.6 1.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3405 PF11885.8 ORX73721.1 - 0.017 13.8 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) TPR_19 PF14559.6 ORX73721.1 - 0.037 14.5 1.6 5.7 7.5 0.1 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4202 PF13875.6 ORX73721.1 - 0.067 13.1 0.0 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) TPR_12 PF13424.6 ORX73721.1 - 0.083 13.2 0.6 1 9.7 0.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73721.1 - 0.15 12.2 7.1 2.5 8.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat FXa_inhibition PF14670.6 ORX73722.1 - 0.044 14.1 0.9 0.086 13.1 0.9 1.6 1 1 0 1 1 1 0 Coagulation Factor Xa inhibitory site DUF4033 PF13225.6 ORX73722.1 - 0.1 12.6 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4033) Ribosomal_S15 PF00312.22 ORX73723.1 - 1.7e-14 53.8 0.2 1.9e-14 53.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 Mito_carr PF00153.27 ORX73724.1 - 1.3e-30 105.2 4.1 3.9e-14 52.3 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX73724.1 - 0.0092 15.2 0.1 0.038 13.1 0.0 2.0 2 0 0 2 2 2 1 Gammaproteobacterial serine protease TMF_TATA_bd PF12325.8 ORX73725.1 - 7.3e-20 71.3 10.5 7.3e-20 71.3 10.5 5.5 4 1 2 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 ORX73725.1 - 4.4e-11 42.6 11.3 4.4e-11 42.6 11.3 8.0 5 2 3 8 8 8 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 ORX73725.1 - 0.00022 21.5 36.9 0.00082 19.6 12.9 6.0 2 1 3 5 5 5 2 Autophagy protein 16 (ATG16) DUF812 PF05667.11 ORX73725.1 - 0.00024 20.1 6.8 0.00024 20.1 6.8 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF812) GAS PF13851.6 ORX73725.1 - 0.0013 18.1 15.1 0.0013 18.1 15.1 5.3 2 1 3 5 5 5 2 Growth-arrest specific micro-tubule binding HAP1_N PF04849.13 ORX73725.1 - 0.0051 16.0 6.7 0.0051 16.0 6.7 5.1 2 1 2 4 4 4 1 HAP1 N-terminal conserved region SAB PF04382.13 ORX73725.1 - 0.017 15.2 0.1 0.091 12.9 0.1 2.4 1 0 0 1 1 1 0 SAB domain Filament PF00038.21 ORX73725.1 - 0.023 14.3 67.8 0.4 10.2 8.5 3.7 3 1 1 4 4 4 0 Intermediate filament protein FPP PF05911.11 ORX73725.1 - 0.078 11.2 56.0 0.0076 14.5 25.4 3.3 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil Macoilin PF09726.9 ORX73725.1 - 0.15 10.6 63.8 0.2 10.2 5.2 3.5 2 1 1 3 3 3 0 Macoilin family F-box-like PF12937.7 ORX73726.1 - 0.0057 16.5 0.1 0.017 15.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like RCC1 PF00415.18 ORX73727.1 - 3.4e-77 254.9 6.5 2.1e-12 47.4 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX73727.1 - 9.7e-46 152.7 33.0 1.7e-08 34.0 0.3 8.2 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat HC2 PF07382.11 ORX73727.1 - 1.6 8.8 46.4 0.21 11.7 42.5 1.5 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 zf-Mss51 PF13824.6 ORX73728.1 - 8.3e-20 70.7 8.7 1.4e-19 69.9 8.7 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 Lar_restr_allev PF14354.6 ORX73728.1 - 1.2 9.6 5.6 2.1 8.8 5.6 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar SPX PF03105.19 ORX73729.1 - 2.8e-27 96.6 0.2 1.2e-26 94.6 0.2 1.8 1 1 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.25 ORX73729.1 - 1.7e-07 31.0 7.8 3e-07 30.2 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX73729.1 - 1.3e-06 28.3 5.0 2.3e-06 27.5 5.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ORX73729.1 - 4.9e-06 26.6 7.6 8.6e-06 25.8 7.6 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ORX73729.1 - 9.3e-06 25.4 8.2 1.7e-05 24.6 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX73729.1 - 1e-05 25.3 7.7 1.7e-05 24.6 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX73729.1 - 0.00013 21.9 8.6 0.00034 20.5 8.7 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ORX73729.1 - 0.00014 22.1 9.5 0.00024 21.4 9.5 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ORX73729.1 - 0.019 14.8 8.0 0.051 13.4 8.0 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 ORX73729.1 - 0.043 13.9 2.5 0.091 12.9 2.5 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 ORX73729.1 - 0.057 13.3 3.3 0.12 12.3 3.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ORX73729.1 - 0.44 10.4 7.8 0.14 12.0 4.1 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 ORX73729.1 - 3.9 7.8 10.2 18 5.7 10.2 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain RGS PF00615.19 ORX73730.1 - 4.2e-08 33.5 0.0 2.1e-06 28.0 0.0 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain 7tm_3 PF00003.22 ORX73730.1 - 0.0033 17.2 21.4 0.07 12.8 21.4 2.2 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7tm_3 PF00003.22 ORX73731.1 - 0.015 15.0 24.1 0.47 10.1 24.1 2.3 1 1 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR RELT PF12606.8 ORX73731.1 - 0.11 11.5 4.8 0.38 9.8 4.8 1.9 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 YqhR PF11085.8 ORX73731.1 - 0.43 10.5 6.8 0.037 14.0 1.6 1.8 2 0 0 2 2 2 0 Conserved membrane protein YqhR PPR_2 PF13041.6 ORX73732.1 - 1.9e-23 82.4 0.2 5.1e-09 36.2 0.0 4.7 3 2 1 4 4 4 4 PPR repeat family PPR PF01535.20 ORX73732.1 - 9.6e-21 72.5 0.3 3.4e-05 23.8 0.0 5.4 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ORX73732.1 - 1.9e-17 63.1 0.0 9.6e-07 28.8 0.0 3.6 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX73732.1 - 2.8e-14 52.5 0.0 1.4e-05 24.7 0.0 3.9 3 1 1 4 4 4 3 PPR repeat PPR_long PF17177.4 ORX73732.1 - 4.6e-06 26.2 0.0 0.0099 15.3 0.0 3.1 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP Pet127 PF08634.10 ORX73734.1 - 5.2e-83 278.6 11.0 4.8e-45 154.1 3.2 2.2 1 1 1 2 2 2 2 Mitochondrial protein Pet127 GPI-anchored PF10342.9 ORX73735.1 - 1.4e-16 61.0 0.0 2.6e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CRIM PF16978.5 ORX73735.1 - 0.11 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain GPI-anchored PF10342.9 ORX73737.1 - 8.9e-09 36.0 0.1 8.9e-09 36.0 0.1 2.2 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF572 PF04502.13 ORX73737.1 - 0.036 13.7 5.6 0.039 13.6 5.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PPP4R2 PF09184.11 ORX73737.1 - 0.058 13.0 4.5 0.061 12.9 4.5 1.1 1 0 0 1 1 1 0 PPP4R2 SLC12 PF03522.15 ORX73737.1 - 0.24 10.4 0.6 0.29 10.1 0.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4366 PF14283.6 ORX73737.1 - 0.61 10.1 5.5 0.24 11.4 2.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) GREB1 PF15782.5 ORX73737.1 - 0.83 6.7 6.4 0.81 6.7 6.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SAPS PF04499.15 ORX73737.1 - 0.88 8.3 2.9 0.9 8.3 2.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SOG2 PF10428.9 ORX73737.1 - 2.4 7.3 17.3 2.7 7.1 17.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RR_TM4-6 PF06459.12 ORX73737.1 - 4.5 7.0 8.8 5.7 6.7 8.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CagY_M PF07337.11 ORX73740.1 - 0.079 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 DC-EC Repeat Peptidase_M50 PF02163.22 ORX73741.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M50 Gate PF07670.14 ORX73741.1 - 2.4 8.5 7.9 2.7 8.3 0.0 3.3 3 1 0 3 3 3 0 Nucleoside recognition WSD PF15613.6 ORX73742.1 - 0.033 14.7 0.8 0.069 13.6 0.8 1.6 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif GET2 PF08690.10 ORX73743.1 - 0.029 14.1 7.1 0.2 11.3 7.6 1.9 2 0 0 2 2 2 0 GET complex subunit GET2 CAML PF14963.6 ORX73743.1 - 0.068 13.3 6.7 0.091 12.9 6.7 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SRP-alpha_N PF04086.13 ORX73743.1 - 4.5 7.1 9.1 5.9 6.7 9.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ribosomal_S19 PF00203.21 ORX73744.1 - 2e-34 117.3 0.9 2.7e-34 116.9 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.16 ORX73744.1 - 0.12 12.4 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar assembly protein FliH EpmC PF04315.12 ORX73744.1 - 0.19 11.4 0.0 6.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Elongation factor P hydroxylase WD40 PF00400.32 ORX73745.1 - 8.7e-23 80.2 3.8 4.8e-07 30.4 0.0 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73745.1 - 2e-06 28.0 0.0 0.022 15.0 0.0 3.7 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 ORX73745.1 - 0.0026 17.1 0.0 0.01 15.2 0.0 1.8 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 ORX73745.1 - 0.0043 16.1 0.1 0.057 12.4 0.0 2.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX73745.1 - 0.0069 15.1 0.0 0.37 9.4 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX73745.1 - 0.12 11.7 0.0 1.5 8.1 0.0 1.9 1 1 0 2 2 2 0 WD40-like domain Rax2 PF12768.7 ORX73746.1 - 4.8e-33 114.4 0.2 2.3e-30 105.6 0.0 3.6 4 0 0 4 4 4 2 Cortical protein marker for cell polarity SH3_1 PF00018.28 ORX73746.1 - 1.8e-07 30.6 0.0 3.4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX73746.1 - 3.1e-07 30.1 0.0 6.9e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX73746.1 - 0.0003 20.4 0.0 0.00077 19.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain LapA_dom PF06305.11 ORX73746.1 - 0.59 10.0 1.9 1.4 8.8 1.9 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Thiolase_N PF00108.23 ORX73747.1 - 1e-74 251.2 0.2 1.3e-74 250.9 0.2 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 ORX73747.1 - 1.4e-06 28.1 0.3 2.2e-06 27.5 0.3 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Aminotran_3 PF00202.21 ORX73748.1 - 3.9e-116 388.1 0.0 4.5e-116 387.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ORX73748.1 - 0.00033 19.9 0.0 0.0005 19.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Mito_carr PF00153.27 ORX73749.1 - 1.9e-48 162.3 1.8 7.2e-22 77.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_22 PF03901.17 ORX73750.1 - 1.4e-36 126.6 25.6 1.9e-36 126.2 25.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family WD40 PF00400.32 ORX73751.1 - 2.2e-09 37.8 5.2 0.042 14.7 0.3 6.0 5 1 0 5 5 5 3 WD domain, G-beta repeat Dynein_IC2 PF11540.8 ORX73751.1 - 2.1e-06 27.6 1.7 4e-06 26.7 1.7 1.4 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 UPF0242 PF06785.11 ORX73751.1 - 0.026 14.6 2.3 0.035 14.2 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2852 PF11014.8 ORX73751.1 - 0.12 12.6 3.3 5.9 7.1 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) HAND PF09110.11 ORX73751.1 - 0.33 11.7 4.5 0.55 11.0 4.5 1.3 1 0 0 1 1 1 0 HAND PQQ_3 PF13570.6 ORX73751.1 - 0.33 11.5 2.0 7.1 7.3 0.4 2.9 2 0 0 2 2 2 0 PQQ-like domain LSM PF01423.22 ORX73752.1 - 4.1e-16 58.4 0.5 5.2e-16 58.1 0.5 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX73752.1 - 0.029 14.5 0.0 0.048 13.8 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain DUF5440 PF17509.2 ORX73752.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5440) DUF2774 PF11242.8 ORX73754.1 - 0.11 12.8 0.7 0.34 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) ABC_membrane PF00664.23 ORX73757.1 - 2.3e-16 60.2 0.0 2.3e-16 60.2 0.0 2.6 3 0 0 3 3 3 1 ABC transporter transmembrane region HBD PF18534.1 ORX73757.1 - 0.045 13.9 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Helical bundle domain ABC_membrane PF00664.23 ORX73758.1 - 7.9e-26 91.3 4.7 1.1e-25 90.8 4.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX73758.1 - 4.2e-17 62.9 0.0 8.5e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX73758.1 - 0.00031 20.3 0.0 0.00032 20.2 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain BNIP2 PF12496.8 ORX73758.1 - 0.13 12.7 1.1 0.32 11.5 1.1 1.5 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 ASF1_hist_chap PF04729.13 ORX73759.1 - 2e-53 180.4 0.4 2.2e-53 180.3 0.4 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone FAA_hydrolase PF01557.18 ORX73760.1 - 5e-49 166.9 0.1 2.3e-48 164.8 0.1 1.8 1 1 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family KH_2 PF07650.17 ORX73760.1 - 0.1 12.4 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 0 KH domain Nop52 PF05997.12 ORX73761.1 - 4.5e-43 147.6 0.9 4.9e-43 147.4 0.9 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 zf-C2H2_jaz PF12171.8 ORX73762.1 - 6.7e-05 23.1 3.2 0.00014 22.0 3.2 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DNA_RNApol_7kD PF03604.13 ORX73763.1 - 1.3e-17 63.1 6.7 2.2e-17 62.4 6.7 1.4 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit MCM_OB PF17207.3 ORX73763.1 - 0.0012 18.7 0.8 0.0013 18.6 0.8 1.1 1 0 0 1 1 1 1 MCM OB domain DZR PF12773.7 ORX73763.1 - 0.0063 16.5 1.3 0.011 15.7 1.3 1.4 1 1 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 ORX73763.1 - 0.012 15.6 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.6 ORX73763.1 - 0.024 14.5 2.7 3.4 7.6 0.1 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain zinc_ribbon_13 PF09855.9 ORX73763.1 - 0.025 14.7 2.5 0.026 14.7 0.2 1.8 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zinc_ribbon_10 PF10058.9 ORX73763.1 - 0.039 13.7 2.0 0.16 11.7 0.1 2.1 1 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Rubredoxin_2 PF18073.1 ORX73763.1 - 0.045 13.5 2.4 2.2 8.1 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain DUF2197 PF09963.9 ORX73763.1 - 0.045 14.0 3.7 0.51 10.6 0.2 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) GFA PF04828.14 ORX73763.1 - 0.071 13.5 0.8 2.7 8.4 0.0 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-Mss51 PF13824.6 ORX73763.1 - 0.083 13.0 1.7 1.9 8.7 0.1 2.2 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-Sec23_Sec24 PF04810.15 ORX73763.1 - 0.21 11.6 3.2 11 6.2 1.2 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Solute_trans_a PF03619.16 ORX73764.1 - 8.5e-77 258.2 11.8 1.1e-76 257.9 11.8 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha TRAM_LAG1_CLN8 PF03798.16 ORX73766.1 - 2.2e-15 57.0 10.0 2.9e-15 56.5 10.0 1.2 1 0 0 1 1 1 1 TLC domain TRAM_LAG1_CLN8 PF03798.16 ORX73767.1 - 1.7e-11 44.2 15.1 5.2e-11 42.7 15.1 1.8 1 1 0 1 1 1 1 TLC domain TFR_dimer PF04253.15 ORX73768.1 - 3.8e-22 78.7 0.1 7.4e-22 77.7 0.1 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX73768.1 - 1.9e-19 70.2 0.0 4.7e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX73768.1 - 4.5e-07 29.8 0.0 1.4e-06 28.2 0.0 1.9 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX73768.1 - 0.15 11.8 0.1 0.39 10.4 0.1 1.8 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ORX73769.1 - 6.3e-21 75.0 0.0 1.2e-20 74.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 ORX73769.1 - 4.9e-17 62.2 0.1 6.5e-16 58.5 0.1 2.3 1 1 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 ORX73769.1 - 4.9e-07 29.7 0.0 1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX73769.1 - 0.00065 19.5 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Ribosom_S12_S23 PF00164.25 ORX73770.1 - 6.3e-37 125.7 0.5 6.8e-37 125.6 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 eIF-1a PF01176.19 ORX73770.1 - 0.083 12.7 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 MMADHC PF10229.9 ORX73771.1 - 9.7e-20 71.4 0.0 1.6e-19 70.8 0.0 1.2 1 1 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein TRAPP PF04051.16 ORX73772.1 - 3.2e-38 130.7 0.0 3.6e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pro_isomerase PF00160.21 ORX73773.1 - 1.3e-41 142.6 0.0 1.8e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Methyltransf_8 PF05148.15 ORX73774.1 - 1.4e-82 276.8 0.0 1.5e-82 276.7 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 ORX73774.1 - 1.9e-05 25.2 0.1 0.00016 22.3 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX73774.1 - 7.9e-05 22.5 0.1 0.2 11.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ORX73774.1 - 0.0002 22.0 0.2 0.02 15.6 0.2 2.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX73774.1 - 0.001 18.7 0.1 0.66 9.5 0.1 2.5 2 1 0 3 3 3 2 Methyltransferase small domain Ubie_methyltran PF01209.18 ORX73774.1 - 0.0041 16.5 0.1 0.012 15.0 0.0 1.7 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 ORX73774.1 - 0.0071 15.0 0.0 0.53 8.8 0.0 2.1 1 1 1 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase Acyl_transf_1 PF00698.21 ORX73775.1 - 3.5e-27 95.7 4.5 1.6e-26 93.6 4.5 1.9 1 1 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 ORX73775.1 - 0.042 13.6 0.6 0.38 10.4 0.6 2.1 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Beta_elim_lyase PF01212.21 ORX73775.1 - 0.08 12.2 2.0 0.59 9.4 2.0 2.3 1 1 0 1 1 1 0 Beta-eliminating lyase Ctr PF04145.15 ORX73776.1 - 3.5e-24 86.1 12.8 9.5e-23 81.4 12.8 2.0 1 1 0 1 1 1 1 Ctr copper transporter family DUF5518 PF17647.1 ORX73776.1 - 0.0003 20.9 2.8 0.0015 18.7 1.2 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5518) Abhydrolase_1 PF00561.20 ORX73778.1 - 6.4e-05 22.7 0.2 0.00014 21.7 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold GFO_IDH_MocA PF01408.22 ORX73781.1 - 1.1e-24 87.6 0.0 1.8e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ORX73781.1 - 2.6e-07 30.6 0.0 6.6e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 ORX73781.1 - 0.014 16.0 0.0 0.23 12.2 0.0 2.4 2 0 0 2 2 2 0 CoA binding domain F420_oxidored PF03807.17 ORX73781.1 - 0.02 15.5 0.0 0.048 14.2 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ORX73781.1 - 0.045 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase PE_PPE_C PF12484.8 ORX73782.1 - 0.13 13.2 3.0 7.9 7.5 0.5 2.4 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal Antimicrobial21 PF14861.6 ORX73782.1 - 0.86 9.4 4.7 4.3 7.1 0.0 3.2 3 0 0 3 3 3 0 Plant antimicrobial peptide Alk_phosphatase PF00245.20 ORX73783.1 - 4.9e-95 318.9 0.0 5.6e-95 318.7 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX73783.1 - 0.004 16.5 0.0 0.0077 15.6 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Ald_Xan_dh_C2 PF02738.18 ORX73784.1 - 7.8e-175 582.5 0.1 1.1e-174 582.0 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ORX73784.1 - 9.7e-29 100.3 0.1 3.6e-28 98.4 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.20 ORX73784.1 - 1.8e-27 95.1 0.1 5.9e-27 93.5 0.1 2.0 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.22 ORX73784.1 - 3.7e-27 94.9 0.0 8.9e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 ORX73784.1 - 1.4e-12 47.7 0.1 6e-12 45.7 0.1 2.1 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 ORX73784.1 - 0.0001 22.2 0.0 0.00036 20.4 0.0 2.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DHHA1 PF02272.19 ORX73784.1 - 0.16 12.4 0.0 2.4 8.6 0.0 2.5 2 0 0 2 2 2 0 DHHA1 domain F-box-like PF12937.7 ORX73785.1 - 0.0097 15.8 1.0 0.016 15.1 1.0 1.5 1 1 0 1 1 1 1 F-box-like Glyco_hydro_52 PF03512.13 ORX73787.1 - 0.01 14.8 0.0 0.012 14.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 Torsin PF06309.11 ORX73787.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 2 0 0 2 2 2 0 Torsin WD40 PF00400.32 ORX73788.1 - 1.8e-24 85.6 4.0 1e-09 38.8 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73788.1 - 0.0004 20.6 0.0 0.037 14.3 0.0 3.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_B PF00136.21 ORX73789.1 - 3.7e-64 217.1 0.0 7.6e-63 212.8 0.0 2.9 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX73789.1 - 1.1e-11 44.4 0.0 1.8e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 ORX73789.1 - 0.012 14.5 0.0 0.019 13.9 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral adh_short PF00106.25 ORX73790.1 - 2.7e-09 36.8 0.0 4.1e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73790.1 - 0.00027 20.6 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PRP3 PF08572.10 ORX73790.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.2 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Ferrochelatase PF00762.19 ORX73791.1 - 6e-89 298.3 0.0 1.4e-88 297.1 0.0 1.5 1 1 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 ORX73791.1 - 0.0079 16.5 0.0 0.51 10.7 0.0 2.7 2 0 0 2 2 2 1 CbiX ApoC-I PF04691.12 ORX73791.1 - 0.19 11.7 0.4 6.5 6.8 0.0 2.8 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) TFR_dimer PF04253.15 ORX73792.1 - 2.6e-21 76.0 0.0 4.8e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX73792.1 - 1.6e-13 50.8 0.0 4.2e-13 49.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX73792.1 - 7.8e-12 45.1 0.0 1.8e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX73792.1 - 0.048 13.4 0.0 0.15 11.8 0.0 1.7 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 TFR_dimer PF04253.15 ORX73793.1 - 4.5e-25 88.1 0.0 7.9e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX73793.1 - 8.1e-25 87.7 0.0 1.5e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX73793.1 - 9.4e-12 44.8 0.0 2.1e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX73793.1 - 0.028 14.1 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 ETC_C1_NDUFA5 PF04716.14 ORX73794.1 - 4.5e-27 93.7 1.0 6.3e-27 93.2 1.0 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region DUF1487 PF07368.11 ORX73794.1 - 0.16 11.4 0.1 0.22 11.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) DUF423 PF04241.15 ORX73795.1 - 2.4e-22 78.9 2.8 3.9e-22 78.2 2.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) tRNA_bind PF01588.20 ORX73796.1 - 1.9e-29 101.6 0.0 5.4e-29 100.2 0.0 1.8 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 ORX73796.1 - 0.002 18.3 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX73796.1 - 0.0038 17.4 0.1 0.011 15.9 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Arg_decarbox_C PF17944.1 ORX73796.1 - 0.043 14.4 0.1 0.24 12.0 0.1 2.3 1 1 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension Steroid_dh PF02544.16 ORX73797.1 - 2.4e-16 60.0 2.4 2.4e-16 60.0 2.4 3.9 3 1 1 4 4 4 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 ORX73797.1 - 0.12 12.8 0.2 0.12 12.8 0.2 2.7 3 0 0 3 3 3 0 Phospholipid methyltransferase DEAD PF00270.29 ORX73798.1 - 4.2e-31 108.1 0.0 7.5e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX73798.1 - 8.4e-21 74.4 0.0 5.4e-20 71.8 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX73798.1 - 0.00044 20.3 0.1 0.00092 19.3 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX73798.1 - 0.093 11.9 0.1 0.3 10.3 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase INTS2 PF14750.6 ORX73799.1 - 1.7e-54 184.9 7.4 1.1e-46 159.0 11.0 2.1 2 0 0 2 2 2 2 Integrator complex subunit 2 RPA PF10134.9 ORX73799.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication initiator protein A Glycos_transf_1 PF00534.20 ORX73801.1 - 1.2e-13 50.9 0.0 6.5e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX73801.1 - 3e-05 24.4 0.0 7.9e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 RGCC PF15151.6 ORX73802.1 - 0.028 14.6 0.1 0.089 13.0 0.0 1.8 2 0 0 2 2 2 0 Response gene to complement 32 protein family RRM_1 PF00076.22 ORX73802.1 - 0.11 12.4 0.0 23 4.9 0.0 2.9 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-DNL PF05180.12 ORX73803.1 - 3.6e-32 110.1 1.5 4e-32 110.0 1.5 1.0 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.13 ORX73803.1 - 0.012 15.6 0.4 0.012 15.6 0.4 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like CGGC PF08821.11 ORX73803.1 - 0.019 15.1 0.4 0.02 15.0 0.4 1.2 1 0 0 1 1 1 0 CGGC domain DUF3834 PF12916.7 ORX73803.1 - 0.044 13.0 0.1 0.05 12.8 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) TFIIS_C PF01096.18 ORX73803.1 - 0.3 11.0 6.1 6.7 6.6 1.0 2.1 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_4 PF13717.6 ORX73803.1 - 0.33 10.9 4.8 0.61 10.1 0.1 2.4 2 1 1 3 3 3 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 ORX73803.1 - 0.55 9.9 4.3 6.3 6.5 0.3 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Oxidored_q2 PF00420.24 ORX73804.1 - 0.23 11.1 8.5 0.07 12.8 1.7 2.4 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Hydantoinase_B PF02538.14 ORX73805.1 - 2.5e-218 725.7 0.7 3.4e-218 725.3 0.7 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 ORX73805.1 - 4.6e-97 324.8 1.1 8.4e-97 323.9 0.2 1.9 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 ORX73805.1 - 1.4e-48 165.0 0.5 1.9e-46 158.0 0.0 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Helicase_C PF00271.31 ORX73806.1 - 8.6e-16 58.3 0.0 2.4e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX73806.1 - 9.6e-14 51.5 0.0 3.9e-13 49.6 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 ORX73806.1 - 4.2e-06 27.4 0.3 1.2e-05 25.9 0.3 1.8 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 ORX73806.1 - 0.0093 16.0 0.0 0.031 14.3 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Glyco_transf_43 PF03360.16 ORX73806.1 - 0.08 12.8 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 43 RCC1 PF00415.18 ORX73807.1 - 7e-38 129.0 13.1 2.2e-09 37.8 0.0 7.5 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX73807.1 - 1.3e-22 79.0 21.7 1.4e-06 27.9 0.1 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat DASH_Duo1 PF08651.10 ORX73808.1 - 3.9e-13 49.0 0.7 5.4e-13 48.5 0.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 Auts2 PF15336.6 ORX73808.1 - 0.0081 16.3 3.3 0.011 15.8 3.3 1.2 1 0 0 1 1 1 1 Autism susceptibility gene 2 protein AAA_lid_7 PF17867.1 ORX73808.1 - 0.035 14.3 1.0 0.053 13.7 1.0 1.4 1 1 0 1 1 1 0 Midasin AAA lid domain Borrelia_P83 PF05262.11 ORX73808.1 - 0.092 11.2 5.8 0.1 11.1 5.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DMRT-like PF15791.5 ORX73808.1 - 0.28 11.6 2.4 0.29 11.6 1.8 1.4 1 1 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 Caldesmon PF02029.15 ORX73808.1 - 0.35 9.6 16.2 0.48 9.1 16.2 1.2 1 0 0 1 1 1 0 Caldesmon DUF1682 PF07946.14 ORX73808.1 - 1.4 8.1 7.8 1.6 7.9 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Rrn6 PF10214.9 ORX73808.1 - 1.9 6.9 5.6 2 6.8 5.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TarH PF02203.15 ORX73808.1 - 9.6 6.1 7.9 13 5.6 7.9 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue TFIID-18kDa PF02269.16 ORX73809.1 - 4.1e-26 90.8 0.0 4.8e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Pkinase PF00069.25 ORX73810.1 - 2.7e-08 33.5 0.0 3.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.20 ORX73810.1 - 6.7e-07 29.1 0.1 0.022 14.4 0.1 2.2 1 1 1 2 2 2 2 Choline/ethanolamine kinase WaaY PF06176.11 ORX73810.1 - 1.9e-06 27.7 0.1 2.7e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 ORX73810.1 - 1.5e-05 24.7 0.0 4.1e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 ORX73810.1 - 0.00021 20.7 0.0 0.00052 19.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX73810.1 - 0.00037 20.5 0.0 0.00052 20.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX73810.1 - 0.0036 16.7 0.0 0.0071 15.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX73810.1 - 0.0091 14.8 0.1 0.016 14.0 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ORX73810.1 - 0.074 12.1 0.1 0.16 11.0 0.1 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 AAA_2 PF07724.14 ORX73811.1 - 4.1e-55 186.5 0.0 5.1e-50 169.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ORX73811.1 - 1.3e-33 115.0 0.8 1.3e-33 115.0 0.8 2.6 3 0 0 3 3 2 1 AAA lid domain AAA PF00004.29 ORX73811.1 - 5.2e-29 101.3 0.0 2.4e-15 57.1 0.0 3.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX73811.1 - 4.4e-21 75.3 0.5 1.6e-12 47.6 0.0 3.5 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 ORX73811.1 - 3.9e-20 71.7 0.3 4.6e-19 68.2 0.0 3.2 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 ORX73811.1 - 1.4e-15 58.1 1.0 9.1e-07 29.4 0.0 4.7 3 2 1 5 5 4 2 AAA ATPase domain Clp_N PF02861.20 ORX73811.1 - 5.9e-15 55.1 0.9 3e-06 27.3 0.1 3.1 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 ORX73811.1 - 9.9e-10 38.4 0.1 1.9e-06 27.7 0.0 3.7 2 1 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ORX73811.1 - 4.8e-09 36.2 0.0 0.0051 16.6 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 ORX73811.1 - 8.5e-09 35.5 0.2 0.0073 16.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ORX73811.1 - 2.4e-08 33.7 0.0 0.00063 19.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 ORX73811.1 - 3e-08 34.0 1.5 0.0031 17.8 0.1 4.6 2 2 1 3 3 3 2 AAA domain AAA_18 PF13238.6 ORX73811.1 - 5.5e-08 33.4 0.7 0.011 16.2 0.0 3.7 3 1 0 3 3 2 2 AAA domain RuvB_N PF05496.12 ORX73811.1 - 1.8e-07 31.0 1.7 0.1 12.3 0.1 4.4 2 2 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 ORX73811.1 - 4.2e-07 29.6 0.0 0.0011 18.4 0.0 3.7 2 1 0 2 2 2 1 Bacterial TniB protein TIP49 PF06068.13 ORX73811.1 - 6.5e-07 28.9 0.6 0.017 14.4 0.0 2.9 2 1 1 3 3 3 2 TIP49 P-loop domain AAA_33 PF13671.6 ORX73811.1 - 4.8e-06 26.8 1.3 0.043 14.0 0.0 3.9 4 1 0 4 4 3 2 AAA domain T2SSE PF00437.20 ORX73811.1 - 6.8e-06 25.3 2.4 0.00098 18.3 0.1 2.8 3 0 0 3 3 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 ORX73811.1 - 6.8e-06 25.9 0.5 0.027 14.2 0.1 3.6 3 2 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 ORX73811.1 - 1.5e-05 24.4 1.2 0.16 11.2 0.0 3.8 2 1 1 3 3 3 1 Zeta toxin AAA_28 PF13521.6 ORX73811.1 - 3.5e-05 24.1 4.7 0.28 11.4 0.0 3.9 4 0 0 4 4 3 2 AAA domain RNA_helicase PF00910.22 ORX73811.1 - 4.2e-05 23.9 0.0 0.15 12.5 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 ORX73811.1 - 4.9e-05 22.8 0.2 0.48 9.8 0.1 3.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ORX73811.1 - 5.3e-05 23.2 0.0 0.19 11.7 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 ORX73811.1 - 7.2e-05 22.4 1.2 0.014 14.9 0.0 3.4 3 1 0 3 3 3 1 AAA domain ResIII PF04851.15 ORX73811.1 - 0.00011 22.3 0.0 0.032 14.3 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 ORX73811.1 - 0.00014 21.9 0.0 0.67 10.0 0.0 3.1 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ORX73811.1 - 0.00017 22.0 0.2 0.071 13.5 0.1 3.1 3 1 0 3 3 2 1 AAA domain PhoH PF02562.16 ORX73811.1 - 0.00018 21.0 0.2 0.17 11.3 0.0 3.6 4 0 0 4 4 4 1 PhoH-like protein AAA_11 PF13086.6 ORX73811.1 - 0.0003 20.7 7.9 0.14 11.9 0.0 3.7 4 0 0 4 4 3 1 AAA domain DNA_pol3_delta2 PF13177.6 ORX73811.1 - 0.00032 20.5 0.0 0.0075 16.1 0.0 2.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_6 PF12774.7 ORX73811.1 - 0.00038 19.5 0.1 0.07 12.1 0.0 2.7 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_3 PF07726.11 ORX73811.1 - 0.00048 20.0 0.1 0.48 10.3 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ORX73811.1 - 0.0005 20.1 0.1 3.5 7.5 0.0 4.0 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ORX73811.1 - 0.0027 18.2 12.4 0.26 11.8 0.4 4.0 5 0 0 5 5 3 2 AAA domain DnaB_C PF03796.15 ORX73811.1 - 0.0034 16.8 0.0 0.17 11.2 0.0 2.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Roc PF08477.13 ORX73811.1 - 0.0084 16.3 0.0 2.3 8.5 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PEPCK_ATP PF01293.20 ORX73811.1 - 0.0092 14.7 0.1 3.4 6.2 0.0 3.4 3 1 1 4 4 4 1 Phosphoenolpyruvate carboxykinase AAA_24 PF13479.6 ORX73811.1 - 0.01 15.6 0.0 2.6 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX73811.1 - 0.012 16.1 1.0 0.58 10.7 0.0 3.2 3 0 0 3 3 3 0 ABC transporter AAA_29 PF13555.6 ORX73811.1 - 0.012 15.3 0.0 6.1 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Torsin PF06309.11 ORX73811.1 - 0.014 15.5 0.0 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Torsin NTPase_1 PF03266.15 ORX73811.1 - 0.025 14.5 0.1 2.5 8.0 0.0 3.3 3 0 0 3 3 2 0 NTPase Rad17 PF03215.15 ORX73811.1 - 0.034 14.1 0.0 6.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 ORX73811.1 - 0.037 13.1 0.0 0.95 8.5 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 SRP54 PF00448.22 ORX73811.1 - 0.041 13.5 0.0 5.5 6.6 0.0 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain SRPRB PF09439.10 ORX73811.1 - 0.1 12.0 0.8 19 4.6 0.0 2.9 3 0 0 3 3 2 0 Signal recognition particle receptor beta subunit DUF87 PF01935.17 ORX73811.1 - 0.11 12.5 2.6 0.65 10.0 0.0 3.2 3 1 0 3 3 2 0 Helicase HerA, central domain DUF16 PF01519.16 ORX73811.1 - 0.4 11.2 4.4 0.42 11.1 1.6 2.6 2 1 0 2 2 1 0 Protein of unknown function DUF16 DUF2508 PF10704.9 ORX73811.1 - 1.5 9.0 5.2 51 4.1 0.6 4.0 4 0 0 4 4 3 0 Protein of unknown function (DUF2508) Cep57_CLD_2 PF14197.6 ORX73811.1 - 6.2 7.0 16.5 26 5.0 9.8 3.6 3 1 0 3 3 2 0 Centrosome localisation domain of PPC89 Dynactin_p22 PF07426.11 ORX73811.1 - 7.7 6.3 11.4 2.2 8.1 6.4 2.6 2 1 1 3 3 3 0 Dynactin subunit p22 ACBP PF00887.19 ORX73812.1 - 7.4e-28 96.6 0.5 8.4e-28 96.4 0.5 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein CRAL_TRIO_2 PF13716.6 ORX73813.1 - 6.7e-32 110.5 0.1 1.7e-31 109.2 0.3 1.6 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 ORX73813.1 - 5.6e-23 81.4 0.0 1.1e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 ORX73813.1 - 1.1e-06 28.5 0.5 8.1e-06 25.6 0.5 2.1 1 1 0 1 1 1 1 CRAL/TRIO domain YL1 PF05764.13 ORX73813.1 - 1.5 8.9 11.2 2.3 8.3 11.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.13 ORX73813.1 - 4.5 5.2 11.2 7.7 4.5 11.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ORX73813.1 - 5.1 5.5 5.9 8.8 4.7 5.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sporozoite_P67 PF05642.11 ORX73813.1 - 6 4.8 9.6 0.41 8.7 3.9 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF92 PF01940.16 ORX73815.1 - 1.6e-70 237.2 3.8 1.9e-70 237.0 3.8 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 Glyco_hydro_19 PF00182.19 ORX73816.1 - 1.2e-12 48.2 0.9 4.4e-11 43.1 0.2 2.3 1 1 0 2 2 2 2 Chitinase class I cobW PF02492.19 ORX73817.1 - 6.1e-41 139.9 0.1 9e-41 139.4 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ORX73817.1 - 0.0039 17.1 0.0 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 ORX73817.1 - 0.012 15.6 0.2 5.9 6.8 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase tRNA_anti-codon PF01336.25 ORX73817.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain AAA_16 PF13191.6 ORX73817.1 - 0.16 12.4 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain zf-UBR PF02207.20 ORX73818.1 - 3.3e-19 68.8 13.3 8.2e-19 67.5 13.3 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 ORX73818.1 - 4.5e-09 36.0 0.1 1.1e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS DUF4092 PF13322.6 ORX73818.1 - 0.13 12.1 0.4 0.69 9.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4092) STE PF02200.16 ORX73820.1 - 0.045 14.2 0.5 0.073 13.5 0.5 1.4 1 1 0 1 1 1 0 STE like transcription factor zf-SNAP50_C PF12251.8 ORX73822.1 - 2.2e-63 213.6 5.0 3.2e-63 213.0 5.0 1.3 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Mpv17_PMP22 PF04117.12 ORX73823.1 - 2.5e-22 78.8 0.2 5.1e-22 77.9 0.2 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family Mpv17_PMP22 PF04117.12 ORX73824.1 - 8.8e-24 83.5 0.1 1.6e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family TPR_12 PF13424.6 ORX73825.1 - 1.2e-06 28.7 12.2 0.0009 19.5 0.9 5.4 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73825.1 - 3.5e-06 26.6 2.5 0.00067 19.4 0.3 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX73825.1 - 0.00036 20.3 12.7 0.01 15.7 0.2 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX73825.1 - 0.0022 18.1 0.1 0.52 10.7 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX73825.1 - 0.0045 17.7 11.6 0.076 13.9 0.3 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX73825.1 - 0.012 15.7 0.5 0.012 15.7 0.5 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX73825.1 - 0.035 14.8 6.5 2.1 9.2 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX73825.1 - 0.043 13.8 4.7 1.9 8.7 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX73825.1 - 0.057 13.1 1.0 2.6 7.8 0.2 3.5 3 1 1 4 4 4 0 TPR repeat MIF4G PF02854.19 ORX73827.1 - 1e-55 188.7 0.4 1.2e-55 188.5 0.4 1.0 1 0 0 1 1 1 1 MIF4G domain DUF1729 PF08354.10 ORX73828.1 - 4.3e-125 417.3 0.0 6.8e-125 416.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX73828.1 - 7.6e-51 173.5 0.0 1.5e-47 162.6 0.0 3.4 3 0 0 3 3 3 2 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX73828.1 - 2.7e-47 161.1 0.0 5.4e-47 160.1 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX73828.1 - 6.7e-40 136.9 0.0 1.3e-39 136.0 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ORX73828.1 - 3e-21 76.2 0.2 7.6e-21 74.8 0.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ORX73828.1 - 2.3e-20 72.4 0.1 5.8e-20 71.1 0.1 1.7 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX73828.1 - 4.6e-20 71.9 0.0 1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX73828.1 - 1.7e-16 60.7 0.0 4.3e-16 59.4 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ORX73828.1 - 2.5e-14 53.3 0.0 8.1e-14 51.6 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain MaoC_dehydrat_N PF13452.6 ORX73828.1 - 8e-06 26.0 0.0 2.3e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 ORX73828.1 - 9.2e-05 22.5 0.0 0.00036 20.5 0.0 2.1 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Kinesin PF00225.23 ORX73829.1 - 1e-93 313.9 0.1 1.2e-93 313.7 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX73829.1 - 3.3e-15 56.3 0.0 7e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HSP70 PF00012.20 ORX73830.1 - 1.1e-169 565.4 1.3 1.1e-169 565.4 1.3 2.1 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ORX73830.1 - 1.3e-12 47.2 0.0 2.4e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein CTP_transf_1 PF01148.20 ORX73831.1 - 4.2e-33 115.3 10.6 5.4e-33 114.9 10.6 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family HIG_1_N PF04588.13 ORX73831.1 - 0.78 10.0 4.2 0.27 11.5 0.6 2.1 2 0 0 2 2 2 0 Hypoxia induced protein conserved region WD40 PF00400.32 ORX73832.1 - 6.7e-16 58.4 14.4 0.0087 16.9 0.0 8.2 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73832.1 - 1.7e-05 25.0 0.0 1.2 9.4 0.0 4.1 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain adh_short_C2 PF13561.6 ORX73834.1 - 8.9e-23 81.1 0.1 4.5e-12 46.0 0.1 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX73834.1 - 1.4e-18 67.1 0.5 3.8e-10 39.5 0.0 3.1 2 1 1 3 3 3 2 short chain dehydrogenase KR PF08659.10 ORX73834.1 - 0.00012 22.0 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Methyltransf_19 PF04672.12 ORX73834.1 - 0.055 12.9 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl methyltransferase adh_short_C2 PF13561.6 ORX73835.1 - 6.7e-53 179.6 0.0 9.1e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX73835.1 - 5.1e-46 156.6 0.0 6.8e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX73835.1 - 1.7e-12 47.6 0.0 3.1e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX73835.1 - 0.0027 16.9 0.0 0.0042 16.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 ORX73835.1 - 0.0029 17.1 0.1 0.0048 16.3 0.1 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ORX73835.1 - 0.0044 16.5 0.1 0.012 15.0 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Methyltransf_PK PF05891.12 ORX73835.1 - 0.0078 15.8 0.1 0.97 8.9 0.0 2.2 1 1 1 2 2 2 2 AdoMet dependent proline di-methyltransferase NAD_binding_7 PF13241.6 ORX73835.1 - 0.023 15.1 0.0 0.16 12.5 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Epimerase PF01370.21 ORX73835.1 - 0.023 14.1 0.0 0.13 11.7 0.0 2.0 1 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX73835.1 - 0.025 13.6 0.0 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.18 ORX73835.1 - 0.027 14.4 0.1 0.1 12.5 0.1 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 ORX73835.1 - 0.029 15.1 0.0 0.27 12.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain F420_oxidored PF03807.17 ORX73835.1 - 0.037 14.6 0.0 0.092 13.3 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent QRPTase_C PF01729.19 ORX73835.1 - 0.037 13.8 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Methyltransf_19 PF04672.12 ORX73835.1 - 0.068 12.6 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl methyltransferase TrkA_N PF02254.18 ORX73835.1 - 0.082 13.2 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 ORX73835.1 - 0.088 13.4 0.2 0.2 12.3 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 ORX73835.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase tRNA-synt_1 PF00133.22 ORX73836.1 - 7.8e-57 192.8 0.0 4.1e-19 68.3 1.4 5.2 1 1 3 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 ORX73836.1 - 1.9e-46 157.9 0.0 3.2e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 ORX73836.1 - 3.9e-26 91.7 0.5 4e-19 68.6 0.0 4.3 4 1 1 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ORX73836.1 - 1.3e-11 44.6 0.0 2.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Ldh_1_N PF00056.23 ORX73837.1 - 1.2e-35 122.7 1.5 4.1e-35 120.9 1.3 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ORX73837.1 - 1e-20 74.3 0.0 2.4e-20 73.1 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 ORX73837.1 - 0.005 15.9 0.0 0.0067 15.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX73837.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 ORX73837.1 - 0.017 15.7 3.5 0.043 14.4 2.0 2.4 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Glyco_hydro_4 PF02056.16 ORX73837.1 - 0.049 13.2 0.2 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase NmrA PF05368.13 ORX73837.1 - 0.091 12.3 0.3 0.14 11.7 0.3 1.3 1 0 0 1 1 1 0 NmrA-like family HTH_24 PF13412.6 ORX73837.1 - 0.17 11.5 0.0 3.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DAO PF01266.24 ORX73837.1 - 0.98 8.9 4.7 1.8 8.1 4.4 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase EF-hand_1 PF00036.32 ORX73838.1 - 3.4e-26 88.8 18.2 1.7e-08 33.4 0.9 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX73838.1 - 2.3e-24 85.6 6.3 3.2e-14 53.1 0.9 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX73838.1 - 5.2e-19 66.5 16.1 0.00013 21.6 0.1 4.8 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ORX73838.1 - 1.8e-17 61.9 20.6 1.7e-07 30.4 1.3 4.5 4 1 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ORX73838.1 - 2.7e-16 59.1 16.9 0.00083 19.2 0.6 4.6 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX73838.1 - 6.8e-09 36.0 0.0 0.0017 18.6 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ORX73838.1 - 3.4e-05 24.1 0.2 0.11 12.8 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 ORX73838.1 - 3.5e-05 23.7 5.8 0.81 9.7 0.4 3.7 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ORX73838.1 - 4.1 7.7 8.0 0.67 10.2 1.9 2.7 2 2 0 2 2 2 0 Dockerin type I domain E1-E2_ATPase PF00122.20 ORX73839.1 - 6.8e-27 94.1 6.7 1e-12 47.9 1.1 3.9 4 1 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 ORX73839.1 - 1.4e-16 61.4 0.2 2.5e-10 41.0 0.1 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 ORX73839.1 - 1.7e-15 57.2 0.0 4.1e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase_C PF00689.21 ORX73839.1 - 2.1e-08 34.1 2.6 7.5e-08 32.3 2.6 1.9 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 ORX73839.1 - 0.0013 18.4 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX73839.1 - 0.018 15.1 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX73839.1 - 0.047 13.4 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase CAAD PF14159.6 ORX73839.1 - 0.34 10.8 3.0 0.54 10.1 0.1 2.8 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase E1-E2_ATPase PF00122.20 ORX73840.1 - 8.2e-29 100.4 1.8 9.8e-29 100.1 0.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase P5-ATPase PF12409.8 ORX73840.1 - 8e-22 77.7 0.0 1.8e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 ORX73840.1 - 6.8e-12 46.1 0.6 0.00017 22.0 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ORX73840.1 - 1.5e-08 34.6 4.1 3.5e-08 33.4 4.1 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX73840.1 - 0.0016 18.5 0.0 0.0037 17.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX73840.1 - 0.021 14.5 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Tox-WTIP PF15654.6 ORX73840.1 - 0.12 12.8 0.0 0.46 10.9 0.0 2.0 1 0 0 1 1 1 0 Toxin with a conserved tryptophan and TIP tripeptide motif Coa1 PF08695.10 ORX73841.1 - 6.1e-25 87.3 0.1 6.8e-25 87.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF2157 PF09925.9 ORX73841.1 - 0.037 13.8 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF4987 PF16377.5 ORX73841.1 - 0.076 13.2 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Muraidase PF11860.8 ORX73841.1 - 0.11 12.7 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 N-acetylmuramidase MMR_HSR1 PF01926.23 ORX73842.1 - 1.2e-23 83.3 0.0 2.8e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX73842.1 - 2.1e-09 37.1 0.0 3.9e-09 36.2 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX73842.1 - 3.4e-08 33.6 0.0 0.00034 20.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX73842.1 - 1.2e-06 28.2 0.7 0.0011 18.6 0.7 3.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX73842.1 - 1.4e-06 28.5 0.1 0.065 13.3 0.0 2.3 1 1 1 2 2 2 2 Dynamin family Septin PF00735.18 ORX73842.1 - 0.0014 17.9 0.1 0.0064 15.8 0.1 2.1 1 1 0 1 1 1 1 Septin MeaB PF03308.16 ORX73842.1 - 0.0036 16.3 0.6 0.29 10.1 0.2 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 ORX73842.1 - 0.017 14.5 0.0 2.3 7.6 0.0 2.5 2 1 0 2 2 2 0 Bacterial TniB protein SRPRB PF09439.10 ORX73842.1 - 0.02 14.3 0.1 0.058 12.8 0.0 1.9 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 ORX73842.1 - 0.024 15.1 0.2 0.057 13.9 0.2 1.8 1 1 0 1 1 1 0 ABC transporter Roc PF08477.13 ORX73842.1 - 0.029 14.6 0.1 0.081 13.1 0.1 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 ORX73842.1 - 0.037 13.8 0.0 0.19 11.5 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AIG1 PF04548.16 ORX73842.1 - 0.039 13.3 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 AIG1 family RNA_helicase PF00910.22 ORX73842.1 - 0.058 13.8 0.0 0.26 11.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 ORX73842.1 - 0.07 13.4 2.1 16 5.7 0.2 3.7 3 1 0 3 3 3 0 AAA domain MMR_HSR1_Xtn PF16897.5 ORX73842.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain cobW PF02492.19 ORX73842.1 - 0.15 11.6 0.3 3.2 7.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MIF4G PF02854.19 ORX73843.1 - 6.6e-27 94.5 8.0 1.8e-08 34.3 0.0 5.4 4 2 1 5 5 5 4 MIF4G domain Upf2 PF04050.14 ORX73843.1 - 2.2e-10 41.4 10.2 2.2e-10 41.4 10.2 5.2 3 1 1 4 4 4 1 Up-frameshift suppressor 2 Ribosomal_60s PF00428.19 ORX73843.1 - 0.0071 16.9 11.1 0.0071 16.9 11.1 4.7 4 1 1 5 5 5 1 60s Acidic ribosomal protein Ras PF00071.22 ORX73844.1 - 6.4e-22 77.9 0.0 7.2e-22 77.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX73844.1 - 6.2e-16 58.7 0.0 7.5e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX73844.1 - 3.8e-05 23.7 0.0 4.5e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ORX73844.1 - 4.2e-05 23.1 0.0 5.1e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX73844.1 - 0.001 18.4 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ORX73844.1 - 0.0036 17.0 0.1 0.028 14.1 0.1 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 ORX73844.1 - 0.0092 16.4 0.0 0.41 11.1 0.0 2.1 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 ORX73844.1 - 0.03 14.7 0.0 0.038 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NOG1 PF06858.14 ORX73844.1 - 0.096 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) RsgA_GTPase PF03193.16 ORX73844.1 - 0.1 12.5 0.2 2.3 8.1 0.1 2.1 1 1 1 2 2 2 0 RsgA GTPase G-alpha PF00503.20 ORX73844.1 - 0.11 11.6 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit F-box PF00646.33 ORX73845.1 - 1.7e-07 30.9 0.3 8.4e-06 25.5 0.1 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX73845.1 - 4.3e-07 29.7 0.6 4.9e-06 26.3 0.1 2.7 3 0 0 3 3 3 1 F-box-like Cohesin_HEAT PF12765.7 ORX73845.1 - 0.14 12.5 0.1 16 5.9 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion NosD PF05048.13 ORX73846.1 - 0.02 14.1 0.1 0.026 13.8 0.1 1.1 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) adh_short_C2 PF13561.6 ORX73847.1 - 1.4e-32 113.2 1.4 2.7e-21 76.2 1.7 3.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX73847.1 - 1.2e-28 99.9 0.8 5.1e-14 52.2 0.1 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 ORX73847.1 - 1.7e-06 28.1 0.3 4.6e-06 26.7 0.2 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX73847.1 - 0.0078 15.7 1.0 0.82 9.1 0.0 2.6 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family PAS_9 PF13426.7 ORX73848.1 - 1.7e-08 34.6 0.0 3.3e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 ORX73848.1 - 1.8e-06 28.1 0.0 0.11 12.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 ORX73848.1 - 0.00016 21.6 0.0 0.00051 20.0 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 ORX73848.1 - 0.00044 20.5 0.1 0.036 14.3 0.0 2.7 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 ORX73848.1 - 0.065 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 PAS domain PPR PF01535.20 ORX73849.1 - 5.3e-06 26.3 0.4 9.2 6.8 0.0 5.8 4 1 1 5 5 5 3 PPR repeat PPR_2 PF13041.6 ORX73849.1 - 0.067 13.4 0.1 3.8 7.8 0.0 3.5 4 1 0 4 4 4 0 PPR repeat family Septin PF00735.18 ORX73850.1 - 4.3e-29 101.7 4.0 6.7e-16 58.4 1.0 3.6 2 1 0 2 2 2 2 Septin MMR_HSR1 PF01926.23 ORX73850.1 - 5e-07 29.8 0.3 2.4e-06 27.6 0.3 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX73850.1 - 0.0015 18.6 0.1 0.46 10.5 0.0 2.5 2 0 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 ORX73850.1 - 0.0027 17.7 0.3 0.039 13.9 0.2 2.7 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX73850.1 - 0.0063 16.1 0.0 0.058 12.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX73850.1 - 0.039 14.2 0.1 0.32 11.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX73850.1 - 0.067 13.7 0.6 0.28 11.7 0.6 2.1 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ORX73850.1 - 0.096 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX73850.1 - 0.1 13.0 0.0 0.54 10.6 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain NACHT PF05729.12 ORX73850.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.18 ORX73850.1 - 0.11 11.8 0.2 0.28 10.5 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family Cu-oxidase_3 PF07732.15 ORX73851.1 - 2e-40 137.5 2.4 5.9e-37 126.3 0.2 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 ORX73851.1 - 2.6e-33 115.4 0.4 9.5e-31 107.1 0.0 3.0 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX73851.1 - 8.9e-29 100.0 4.5 5.3e-25 87.8 0.3 3.5 3 1 0 3 3 3 2 Multicopper oxidase ABC_membrane_2 PF06472.15 ORX73852.1 - 4.2e-49 167.4 3.6 2.6e-48 164.8 3.6 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX73852.1 - 4e-17 63.0 0.0 9.1e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX73852.1 - 0.0035 17.2 0.0 0.013 15.3 0.1 1.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 ORX73852.1 - 0.0063 16.2 6.8 0.064 12.9 6.8 2.2 1 1 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 ORX73852.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ORX73852.1 - 0.066 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 ORX73852.1 - 0.098 13.1 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX73852.1 - 0.15 12.4 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX73852.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF3584 PF12128.8 ORX73852.1 - 0.19 9.2 0.0 0.28 8.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) zinc_ribbon_16 PF17034.5 ORX73853.1 - 3.8e-14 53.0 4.1 4e-14 52.9 4.1 1.0 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 ORX73853.1 - 0.0025 17.4 11.5 0.0031 17.1 11.5 1.1 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type KH_1 PF00013.29 ORX73857.1 - 3.4e-05 23.6 1.0 7.8e-05 22.4 1.0 1.7 1 0 0 1 1 1 1 KH domain Macoilin PF09726.9 ORX73857.1 - 0.022 13.3 11.1 0.026 13.1 11.1 1.2 1 0 0 1 1 1 0 Macoilin family CDK5_activator PF03261.15 ORX73857.1 - 2.7 7.5 11.6 3.6 7.1 11.6 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF936 PF06075.12 ORX73857.1 - 2.8 6.8 27.0 4.1 6.2 27.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SPX PF03105.19 ORX73857.1 - 9.5 6.0 29.7 15 5.4 29.7 1.4 1 0 0 1 1 1 0 SPX domain KH_1 PF00013.29 ORX73859.1 - 1e-27 95.7 0.0 5e-11 42.3 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ORX73859.1 - 0.00049 19.9 0.3 0.84 9.5 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_4 PF13083.6 ORX73859.1 - 0.0011 18.7 0.0 0.2 11.6 0.0 2.5 2 0 0 2 2 2 2 KH domain DUF3794 PF12673.7 ORX73859.1 - 0.22 11.8 0.0 0.36 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) PCI PF01399.27 ORX73860.1 - 1.1e-09 38.7 0.0 4.5e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 PCI domain TPR_14 PF13428.6 ORX73860.1 - 0.7 10.9 4.7 16 6.6 0.4 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat KH_1 PF00013.29 ORX73861.1 - 5.4e-24 83.8 1.6 2.1e-14 53.1 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 ORX73861.1 - 7.9e-06 25.6 0.4 0.044 13.6 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 ORX73861.1 - 2.9e-05 23.9 3.3 0.013 15.4 0.1 3.3 4 0 0 4 4 4 2 KH domain KH_5 PF13184.6 ORX73861.1 - 0.12 12.5 0.9 18 5.5 0.1 2.3 2 0 0 2 2 2 0 NusA-like KH domain CMAS PF02353.20 ORX73862.1 - 3.8e-26 92.0 0.0 7.8e-26 91.0 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ORX73862.1 - 6.2e-05 23.6 0.1 0.00013 22.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain TT1725 PF18324.1 ORX73862.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical protein TT1725 RAI16-like PF10257.9 ORX73863.1 - 2.1e-61 207.8 0.1 3e-61 207.3 0.1 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Pkinase PF00069.25 ORX73871.1 - 1.1e-51 175.7 0.0 2.2e-51 174.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73871.1 - 2.2e-21 76.3 0.1 4.8e-21 75.2 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 ORX73871.1 - 0.0031 16.6 0.0 0.0049 16.0 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 ORX73871.1 - 0.03 13.3 0.1 0.039 12.9 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX73871.1 - 0.055 13.4 0.6 0.073 13.0 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX73871.1 - 0.12 11.7 0.6 0.46 9.8 0.6 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PRT_C PF08372.10 ORX73872.1 - 4.9e-06 26.4 0.5 4.9e-06 26.4 0.5 2.1 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 ORX73872.1 - 0.0036 16.8 5.1 0.037 13.4 0.3 2.2 2 0 0 2 2 2 2 Plant protein of unknown function (DUF639) DUF3292 PF11696.8 ORX73872.1 - 0.045 12.1 9.6 0.25 9.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Abhydrolase_1 PF00561.20 ORX73874.1 - 9.3e-06 25.5 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX73874.1 - 0.003 16.9 0.0 0.0044 16.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX73874.1 - 0.0032 18.1 0.0 0.0045 17.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydro_lipase PF04083.16 ORX73874.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ORX73875.1 - 9.3e-08 32.0 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX73875.1 - 8.9e-06 25.1 0.0 1.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX73875.1 - 0.0024 18.5 0.0 0.0036 17.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 ORX73875.1 - 0.054 13.0 0.0 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) Hydrolase_4 PF12146.8 ORX73876.1 - 0.003 16.9 0.0 0.15 11.3 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX73876.1 - 0.0034 17.1 0.0 0.093 12.4 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ORX73877.1 - 2.7e-05 23.9 0.0 0.18 11.4 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX73877.1 - 0.033 13.4 0.1 7.8 5.7 0.0 2.3 1 1 1 2 2 2 0 Serine aminopeptidase, S33 tRNA-synt_1c PF00749.21 ORX73878.1 - 5.7e-73 245.5 2.3 1.6e-36 125.8 0.0 3.1 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ORX73878.1 - 1.6e-32 112.8 0.0 3.2e-32 111.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 ORX73878.1 - 1.1e-30 106.8 0.1 8.1e-23 81.2 0.1 2.3 2 0 0 2 2 2 2 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 PF04557.15 ORX73878.1 - 6e-09 36.7 1.0 1.5e-08 35.4 1.0 1.7 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Pkinase PF00069.25 ORX73879.1 - 3.9e-54 183.8 0.0 6.8e-54 183.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73879.1 - 1.7e-43 148.8 0.0 2.6e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX73879.1 - 1.9e-06 27.4 0.0 5.2e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like PBD PF00786.28 ORX73879.1 - 1.4e-05 25.3 0.2 0.0019 18.5 0.0 2.6 2 0 0 2 2 2 1 P21-Rho-binding domain APH PF01636.23 ORX73879.1 - 0.02 14.8 0.1 0.95 9.3 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family SET PF00856.28 ORX73880.1 - 1e-21 78.0 0.1 4e-21 76.1 0.1 1.8 1 1 0 1 1 1 1 SET domain AWS PF17907.1 ORX73880.1 - 0.0027 17.7 1.9 0.0062 16.5 1.9 1.7 1 0 0 1 1 1 1 AWS domain Pre-SET PF05033.16 ORX73880.1 - 0.027 15.1 4.8 0.053 14.2 4.8 1.5 1 0 0 1 1 1 0 Pre-SET motif Erf4 PF10256.9 ORX73881.1 - 2.6e-29 101.6 0.0 2.6e-29 101.6 0.0 1.6 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family TFIIA PF03153.13 ORX73881.1 - 0.011 15.8 27.6 0.013 15.5 27.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 ORX73881.1 - 9.9 4.8 10.9 14 4.3 10.9 1.3 1 0 0 1 1 1 0 Presenilin SRPRB PF09439.10 ORX73883.1 - 7e-39 133.1 0.1 8.8e-39 132.8 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ORX73883.1 - 3.6e-17 62.4 0.1 5.2e-17 61.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX73883.1 - 2.6e-10 40.2 1.4 3.5e-09 36.5 0.5 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 ORX73883.1 - 8.2e-06 25.5 1.3 0.0031 17.1 0.0 2.2 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 ORX73883.1 - 1.1e-05 25.9 0.2 3.7e-05 24.1 0.0 1.8 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX73883.1 - 1.1e-05 25.4 0.1 1.8e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ORX73883.1 - 3.7e-05 23.9 0.0 7.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ORX73883.1 - 4.1e-05 23.9 1.0 0.00028 21.2 1.0 2.1 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 ORX73883.1 - 6.5e-05 22.8 1.2 0.0015 18.4 0.2 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.22 ORX73883.1 - 0.00014 21.5 0.1 0.00021 21.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ORX73883.1 - 0.00017 21.0 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ORX73883.1 - 0.00051 20.5 1.9 0.003 18.0 1.9 2.4 1 1 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 ORX73883.1 - 0.0027 17.7 0.1 0.005 16.8 0.1 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE FeoB_N PF02421.18 ORX73883.1 - 0.0034 16.9 0.5 0.0075 15.8 0.5 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX73883.1 - 0.0042 17.0 1.8 0.02 14.8 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase AAA_5 PF07728.14 ORX73883.1 - 0.0047 16.9 0.1 0.0088 16.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX73883.1 - 0.0065 16.0 0.4 0.013 15.0 0.2 1.6 2 0 0 2 2 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ORX73883.1 - 0.0078 16.0 0.3 0.043 13.6 0.3 2.1 1 1 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 ORX73883.1 - 0.016 14.7 1.8 0.73 9.2 0.1 2.2 1 1 1 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 ORX73883.1 - 0.021 14.6 0.5 0.053 13.3 0.5 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 ORX73883.1 - 0.021 14.8 0.1 0.075 13.1 0.0 1.9 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ORX73883.1 - 0.034 13.8 0.2 0.059 13.1 0.2 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 ORX73883.1 - 0.041 13.8 0.0 0.061 13.2 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 ORX73883.1 - 0.041 12.9 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 ORX73883.1 - 0.042 14.1 0.3 0.11 12.7 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX73883.1 - 0.045 13.5 2.2 0.073 12.8 2.2 1.5 1 1 0 1 1 1 0 AAA domain DUF3619 PF12279.8 ORX73883.1 - 0.055 13.8 1.3 1.2 9.5 0.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF3619) AAA_18 PF13238.6 ORX73883.1 - 0.063 13.8 0.1 0.2 12.2 0.0 1.7 2 1 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 ORX73883.1 - 0.067 12.5 0.4 0.15 11.3 0.2 1.7 1 1 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 ORX73883.1 - 0.072 13.6 0.0 0.13 12.8 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Parvo_NS1 PF01057.17 ORX73883.1 - 0.081 12.0 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 ORX73883.1 - 0.089 12.7 0.4 0.27 11.2 0.4 1.9 1 1 0 1 1 1 0 NACHT domain ResIII PF04851.15 ORX73883.1 - 0.093 12.7 0.9 0.52 10.3 0.9 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit bMG10 PF17973.1 ORX73883.1 - 0.098 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG10 domain SET PF00856.28 ORX73884.1 - 5.8e-18 65.8 0.0 3.3e-17 63.4 0.0 2.0 1 1 0 1 1 1 1 SET domain AWS PF17907.1 ORX73884.1 - 2.7e-13 49.7 8.4 2.7e-13 49.7 8.4 2.7 3 0 0 3 3 3 1 AWS domain Rab5ip PF07019.12 ORX73886.1 - 5.5e-08 33.3 8.0 7.1e-08 32.9 8.0 1.2 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) TB2_DP1_HVA22 PF03134.19 ORX73886.1 - 0.0066 16.3 0.8 0.02 14.8 0.1 2.0 2 1 0 2 2 2 1 TB2/DP1, HVA22 family BP28CT PF08146.12 ORX73887.1 - 1.9e-32 112.3 3.3 3e-32 111.7 0.4 2.5 2 0 0 2 2 2 1 BP28CT (NUC211) domain HEAT_2 PF13646.6 ORX73887.1 - 0.0013 19.1 2.1 1.1 9.7 0.0 4.1 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ORX73887.1 - 0.0024 18.0 4.5 0.17 12.2 0.2 5.0 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 ORX73887.1 - 0.032 14.8 0.5 0.032 14.8 0.5 5.0 6 0 0 6 6 6 0 HEAT-like repeat AadA_C PF18280.1 ORX73887.1 - 2.2 8.5 5.8 5.1 7.3 0.6 3.6 4 0 0 4 4 4 0 Aminoglycoside adenyltransferase C-terminal domain POM121 PF15229.6 ORX73888.1 - 0.011 15.4 3.8 0.02 14.6 3.8 1.3 1 0 0 1 1 1 0 POM121 family MID_MedPIWI PF18296.1 ORX73888.1 - 0.044 13.6 0.0 0.05 13.4 0.0 1.1 1 0 0 1 1 1 0 MID domain of medPIWI RRM_1 PF00076.22 ORX73888.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup192 PF11894.8 ORX73889.1 - 2.8e-180 601.7 0.0 1.3e-166 556.3 0.0 3.1 2 1 0 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 WD40 PF00400.32 ORX73890.1 - 7.2e-16 58.3 2.8 0.001 19.8 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ORX73890.1 - 0.0049 15.7 0.0 1.1 8.0 0.0 3.0 3 0 0 3 3 3 2 Nup133 N terminal like Pkinase PF00069.25 ORX73891.1 - 7.1e-54 182.9 0.1 8.3e-46 156.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73891.1 - 5.9e-32 111.0 0.1 2.2e-29 102.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX73891.1 - 3.2e-08 33.2 0.0 8.9e-08 31.8 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 ORX73891.1 - 1e-05 25.6 1.3 9.1e-05 22.5 1.3 2.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX73891.1 - 3e-05 23.0 0.0 0.00087 18.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 ORX73891.1 - 0.0019 17.8 0.3 0.0019 17.8 0.3 1.6 2 0 0 2 2 2 1 RIO1 family DUF505 PF04458.12 ORX73891.1 - 0.022 13.2 0.0 0.037 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF505) FTA2 PF13095.6 ORX73891.1 - 0.11 12.1 0.2 3.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 ORX73892.1 - 1.5e-36 123.8 8.3 1.1e-07 32.4 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73892.1 - 8e-08 32.5 0.0 1.9 8.9 0.0 5.0 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ORX73892.1 - 3.6e-05 24.1 1.8 0.021 15.3 0.1 3.6 3 1 1 4 4 4 2 PQQ-like domain PQQ_2 PF13360.6 ORX73892.1 - 4.1e-05 23.3 5.9 0.0019 17.8 0.5 2.4 1 1 1 2 2 2 2 PQQ-like domain Nup160 PF11715.8 ORX73892.1 - 0.009 14.7 2.8 1.9 7.0 0.0 3.9 2 1 3 5 5 5 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX73892.1 - 0.023 13.7 0.0 0.52 9.2 0.0 2.6 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Complex1_LYR_2 PF13233.6 ORX73893.1 - 4.5e-15 56.1 0.1 5.5e-15 55.9 0.1 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ORX73893.1 - 2e-09 37.3 0.1 3.1e-09 36.8 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 ORX73893.1 - 0.029 15.0 0.2 0.062 13.9 0.1 1.6 1 1 0 2 2 2 0 Complex1_LYR-like DUF3825 PF12873.7 ORX73894.1 - 0.16 11.4 0.0 0.52 9.7 0.0 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3825) DJ-1_PfpI PF01965.24 ORX73895.1 - 1.9e-41 141.6 0.0 2.2e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 ORX73895.1 - 0.00014 21.7 0.0 0.00015 21.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_5 PF13507.6 ORX73895.1 - 0.0042 16.2 0.0 0.012 14.7 0.0 1.8 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 ORX73895.1 - 0.0049 16.7 0.0 0.0095 15.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 ORX73895.1 - 0.014 15.0 0.0 0.066 12.8 0.0 1.9 1 1 1 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain ThiJ_like PF17124.5 ORX73895.1 - 0.026 14.2 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like SRP54 PF00448.22 ORX73896.1 - 5e-51 173.1 0.7 9.7e-51 172.2 0.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 ORX73896.1 - 1.9e-42 146.2 12.1 1.6e-33 116.9 2.7 2.2 1 1 1 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal MeaB PF03308.16 ORX73896.1 - 2.6e-07 29.9 0.0 5.7e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54_N PF02881.19 ORX73896.1 - 4.8e-07 29.9 0.0 1.8e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 ORX73896.1 - 0.00052 19.8 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 ORX73896.1 - 0.0047 16.4 0.2 0.013 15.0 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CbiA PF01656.23 ORX73896.1 - 0.013 15.5 0.0 0.055 13.5 0.0 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 ORX73896.1 - 0.014 15.5 0.0 0.055 13.6 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_31 PF13614.6 ORX73896.1 - 0.014 15.3 0.0 0.14 12.0 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX73896.1 - 0.022 15.2 0.1 0.26 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ArsA_ATPase PF02374.15 ORX73896.1 - 0.04 13.1 0.1 0.73 9.0 0.0 2.3 1 1 1 2 2 2 0 Anion-transporting ATPase TetR_C_28 PF17937.1 ORX73896.1 - 0.046 14.2 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AAA_22 PF13401.6 ORX73896.1 - 0.063 13.5 0.1 0.46 10.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 ORX73896.1 - 0.078 13.5 0.0 0.35 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 ORX73896.1 - 0.087 12.5 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain VirC1 PF07015.11 ORX73896.1 - 0.13 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 VirC1 protein STIMATE PF12400.8 ORX73897.1 - 4.1e-36 124.3 4.9 7.6e-36 123.4 4.9 1.4 1 0 0 1 1 1 1 STIMATE family Pkinase PF00069.25 ORX73898.1 - 5.7e-68 229.1 0.0 9.7e-68 228.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73898.1 - 1.1e-30 106.8 0.0 1.5e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ORX73898.1 - 1e-15 57.8 0.7 2.6e-15 56.5 0.7 1.7 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 ORX73898.1 - 1e-08 34.9 0.0 2.7e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FHA_2 PF17913.1 ORX73898.1 - 0.00019 21.6 0.0 0.00042 20.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 ORX73898.1 - 0.00059 18.7 0.0 0.0012 17.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX73898.1 - 0.00074 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Yop-YscD_cpl PF16697.5 ORX73898.1 - 0.0029 17.9 0.0 0.016 15.5 0.0 2.1 2 1 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain TBPIP_N PF15517.6 ORX73898.1 - 0.006 16.6 0.3 0.017 15.2 0.3 1.8 1 0 0 1 1 1 1 TBP-interacting protein N-terminus Peptidase_M15 PF01427.17 ORX73898.1 - 0.18 11.6 0.2 4.9 6.9 0.0 2.3 2 0 0 2 2 2 0 D-ala-D-ala dipeptidase Pex2_Pex12 PF04757.14 ORX73899.1 - 4.3e-30 105.0 0.7 6.8e-30 104.3 0.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_5 PF14634.6 ORX73899.1 - 0.00012 22.0 12.2 0.00024 21.0 12.2 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX73899.1 - 0.00079 19.2 3.5 0.00079 19.2 3.5 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX73899.1 - 0.0033 17.4 4.5 0.004 17.1 3.5 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX73899.1 - 0.0037 17.1 12.5 0.0069 16.2 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX73899.1 - 2 8.8 13.1 1.3 9.4 10.5 2.1 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.6 ORX73899.1 - 2.8 8.2 14.4 0.34 11.1 9.5 2.0 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING PRCC PF10253.9 ORX73900.1 - 6.9e-05 23.7 6.0 9.9e-05 23.2 6.0 1.3 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting CBM_19 PF03427.13 ORX73900.1 - 0.034 14.1 4.9 0.034 14.1 4.9 4.5 5 1 0 5 5 5 0 Carbohydrate binding domain (family 19) Presenilin PF01080.17 ORX73900.1 - 3 6.5 5.9 4.4 6.0 5.9 1.3 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ORX73900.1 - 5.5 5.0 6.9 6.7 4.7 6.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.15 ORX73900.1 - 9.6 4.9 7.1 12 4.5 7.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cpn60_TCP1 PF00118.24 ORX73901.1 - 4.8e-26 91.4 0.0 6.5e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_TAF50 PF03326.13 ORX73901.1 - 0.046 12.4 2.7 0.073 11.7 2.7 1.2 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) PIP5K PF01504.18 ORX73903.1 - 3.4e-42 144.6 0.6 5.4e-31 107.8 2.3 3.1 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase ORC6 PF05460.13 ORX73905.1 - 0.0092 15.3 0.9 0.079 12.2 0.1 2.2 2 0 0 2 2 2 1 Origin recognition complex subunit 6 (ORC6) DUF3641 PF12345.8 ORX73905.1 - 0.054 13.5 0.0 9.2 6.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3641) DUF2368 PF10166.9 ORX73905.1 - 0.071 12.7 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) FRG PF08867.11 ORX73905.1 - 0.091 13.7 0.0 0.19 12.7 0.0 1.7 1 0 0 1 1 1 0 FRG domain zf-RING_2 PF13639.6 ORX73906.1 - 1.6e-06 28.3 4.6 3.1e-06 27.4 4.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX73906.1 - 1.8e-05 24.9 3.9 3.1e-05 24.2 3.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX73906.1 - 0.00012 21.9 2.0 0.00022 21.0 2.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX73906.1 - 0.00019 21.2 1.6 0.00034 20.4 1.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX73906.1 - 0.002 18.1 0.6 0.0036 17.3 0.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ORX73906.1 - 0.011 15.9 2.1 0.02 15.1 2.1 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ORX73906.1 - 0.011 15.7 3.0 0.019 14.9 3.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 ORX73906.1 - 0.031 14.0 0.9 0.031 14.0 0.9 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX73906.1 - 0.039 14.0 1.8 0.11 12.5 0.2 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX73906.1 - 0.17 11.8 2.3 0.31 10.9 2.3 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 ORX73906.1 - 0.23 11.7 2.9 7 6.9 2.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 ORX73906.1 - 0.43 10.5 2.5 0.79 9.6 2.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LIM PF00412.22 ORX73907.1 - 2e-38 130.4 36.6 3.8e-13 49.5 7.6 3.2 3 0 0 3 3 3 3 LIM domain zf_UBZ PF18439.1 ORX73907.1 - 6.9e-05 22.4 33.2 0.21 11.2 0.4 6.7 7 0 0 7 7 7 5 Ubiquitin-Binding Zinc Finger DUF2616 PF11077.8 ORX73907.1 - 0.051 13.3 12.7 0.87 9.3 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) DUF4428 PF14471.6 ORX73907.1 - 0.17 11.8 12.6 0.6 10.1 0.1 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4428) DUF1244 PF06844.11 ORX73907.1 - 0.37 11.0 2.0 8 6.7 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1244) PADR1 PF08063.12 ORX73907.1 - 0.5 10.2 0.0 0.5 10.2 0.0 5.1 5 2 2 7 7 7 0 PADR1 (NUC008) domain Zn-ribbon_8 PF09723.10 ORX73907.1 - 0.72 10.0 37.3 1.2 9.4 6.4 6.2 6 0 0 6 6 6 0 Zinc ribbon domain DUF1924 PF09086.11 ORX73907.1 - 5.7 7.4 8.5 0.72 10.2 0.6 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1924) SPC22 PF04573.12 ORX73908.1 - 2.3e-47 160.6 0.1 2.7e-47 160.4 0.1 1.0 1 0 0 1 1 1 1 Signal peptidase subunit TFIIA_gamma_N PF02268.16 ORX73910.1 - 2.9e-25 88.0 0.4 3.9e-25 87.6 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 ORX73910.1 - 6.7e-23 80.6 1.2 9.9e-23 80.0 1.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit CdvA PF18822.1 ORX73910.1 - 0.063 13.1 0.1 0.084 12.7 0.1 1.1 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Citrate_synt PF00285.21 ORX73911.1 - 5.8e-103 344.7 0.0 8.3e-103 344.2 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PDEase_I PF00233.19 ORX73912.1 - 1.3e-54 185.4 0.0 4e-54 183.9 0.0 1.7 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase adh_short PF00106.25 ORX73913.1 - 1.9e-40 138.4 0.6 2.7e-40 137.9 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73913.1 - 6.8e-34 117.4 0.1 9.2e-34 117.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX73913.1 - 0.00054 19.9 0.1 0.00084 19.3 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX73913.1 - 0.00097 18.4 0.4 0.0019 17.4 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ORX73913.1 - 0.0048 15.9 0.2 0.007 15.4 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family zf-C2H2 PF00096.26 ORX73915.1 - 2.3e-09 37.2 11.1 5.1e-06 26.6 1.4 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX73915.1 - 0.00031 21.3 9.8 0.019 15.8 0.8 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX73915.1 - 0.0023 18.3 1.1 0.0023 18.3 1.1 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_8 PF15909.5 ORX73915.1 - 0.0031 17.8 0.9 1.9 8.8 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX73915.1 - 0.041 14.5 0.4 5.5 7.7 0.0 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain Transferase PF02458.15 ORX73919.1 - 1.2e-21 76.9 0.0 3.7e-21 75.3 0.0 1.6 1 1 0 1 1 1 1 Transferase family IMS PF00817.20 ORX73924.1 - 2.7e-38 131.3 0.0 4.9e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 ORX73924.1 - 3.5e-12 46.6 0.1 6.2e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ORX73924.1 - 6.3e-07 29.7 0.1 1.2e-06 28.8 0.1 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain REV1_C PF16727.5 ORX73924.1 - 1.7e-06 28.3 0.2 3.9e-06 27.2 0.2 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain LIG3_BRCT PF16759.5 ORX73924.1 - 1.6e-05 25.1 0.1 3.4e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ORX73924.1 - 0.00023 21.0 0.1 0.00058 19.8 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain Cdd1 PF11731.8 ORX73924.1 - 0.056 13.7 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 Pathogenicity locus mCpol PF18182.1 ORX73924.1 - 0.086 13.2 0.1 0.35 11.2 0.0 2.1 2 0 0 2 2 2 0 minimal CRISPR polymerase domain UBM PF14377.6 ORX73924.1 - 0.09 12.3 2.1 0.36 10.4 0.3 2.7 2 0 0 2 2 2 0 Ubiquitin binding region HHH_5 PF14520.6 ORX73924.1 - 0.12 13.0 0.3 0.52 11.0 0.0 2.3 3 0 0 3 3 3 0 Helix-hairpin-helix domain Inositol_P PF00459.25 ORX73925.1 - 1.1e-46 159.5 0.3 2.9e-46 158.2 0.3 1.7 1 1 0 1 1 1 1 Inositol monophosphatase family Adap_comp_sub PF00928.21 ORX73926.1 - 9.9e-23 80.8 0.0 1.5e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX73926.1 - 0.17 11.8 0.8 0.34 10.8 0.2 1.9 2 0 0 2 2 2 0 Clathrin adaptor complex small chain FIBP PF05427.11 ORX73927.1 - 2.3e-58 198.2 0.0 2.9e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) zf-HIT PF04438.16 ORX73928.1 - 4.9e-09 35.9 10.3 7.1e-09 35.4 10.3 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 ORX73928.1 - 0.031 14.3 10.3 0.054 13.6 10.3 1.4 1 0 0 1 1 1 0 MYND finger zf-C6H2 PF15801.5 ORX73928.1 - 0.39 11.1 9.0 1 9.8 9.0 1.7 1 1 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding L51_S25_CI-B8 PF05047.16 ORX73929.1 - 1.3e-12 47.4 0.0 1.6e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MliC PF09864.9 ORX73929.1 - 0.11 12.4 0.0 0.61 10.1 0.0 1.9 1 1 1 2 2 2 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Membr_traf_MHD PF10540.9 ORX73930.1 - 1.2e-13 51.4 0.3 3.9e-07 30.3 0.2 2.8 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 ORX73930.1 - 1e-07 32.1 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 ORX73930.1 - 0.011 14.3 0.1 1.7 7.1 0.1 2.8 3 0 0 3 3 3 0 Plant family of unknown function (DUF810) Ins_P5_2-kin PF06090.12 ORX73931.1 - 2.2e-72 244.3 0.0 2.5e-72 244.1 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase F-box-like PF12937.7 ORX73932.1 - 0.0015 18.4 0.2 0.0046 16.8 0.1 1.8 2 0 0 2 2 2 1 F-box-like Molybdopterin PF00384.22 ORX73932.1 - 0.083 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase DUF4246 PF14033.6 ORX73934.1 - 8.5e-119 397.6 0.0 2.3e-66 224.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4246) MFS_1 PF07690.16 ORX73935.1 - 8e-40 136.8 42.6 1.1e-39 136.4 42.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX73935.1 - 4e-20 71.8 17.7 5.7e-20 71.3 17.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX73935.1 - 4.5e-12 45.6 14.9 4.5e-12 45.6 14.9 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter Clostridium_P47 PF06597.11 ORX73935.1 - 0.19 10.4 3.0 0.3 9.8 3.0 1.2 1 0 0 1 1 1 0 Clostridium P-47 protein OATP PF03137.20 ORX73935.1 - 0.71 8.1 15.1 0.018 13.3 7.7 2.2 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PIRT PF15099.6 ORX73935.1 - 5.3 6.6 8.2 8.4 6.0 1.3 2.7 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Sec8_exocyst PF04048.14 ORX73936.1 - 1.2e-28 99.8 0.0 6e-28 97.5 0.0 2.2 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 ORX73936.1 - 0.00016 21.0 0.1 0.00048 19.5 0.1 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex HSBP1 PF06825.12 ORX73936.1 - 0.0023 17.8 0.0 0.016 15.0 0.0 2.6 2 0 0 2 2 2 1 Heat shock factor binding protein 1 COG2 PF06148.11 ORX73936.1 - 0.0037 17.4 5.8 0.02 15.0 0.1 3.7 4 1 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 Mce4_CUP1 PF11887.8 ORX73936.1 - 0.0048 16.4 0.2 0.78 9.1 0.1 2.4 2 0 0 2 2 2 2 Cholesterol uptake porter CUP1 of Mce4, putative L31 PF09784.9 ORX73938.1 - 1.9e-33 114.9 0.3 2.1e-33 114.8 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 PseudoU_synth_1 PF01416.20 ORX73939.1 - 6.7e-15 55.5 0.0 5.1e-13 49.4 0.1 2.8 2 1 0 2 2 2 1 tRNA pseudouridine synthase PT PF04886.12 ORX73939.1 - 0.0041 16.6 10.4 0.008 15.7 10.4 1.4 1 0 0 1 1 1 1 PT repeat Amidohydro_1 PF01979.20 ORX73940.1 - 1.1e-20 74.3 0.0 8.9e-19 68.0 0.0 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX73940.1 - 1.2e-11 44.8 1.5 2.8e-09 37.0 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family SRP54 PF00448.22 ORX73941.1 - 8.2e-79 263.8 0.7 8.2e-79 263.8 0.7 2.4 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ORX73941.1 - 2.4e-28 98.7 4.6 2.4e-28 98.7 4.6 4.2 2 1 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 ORX73941.1 - 2.5e-20 72.4 2.4 5.4e-20 71.4 2.4 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 ORX73941.1 - 6e-06 26.0 1.3 5.2e-05 22.9 1.3 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ORX73941.1 - 1.9e-05 23.8 0.7 0.00015 20.9 0.2 2.5 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ORX73941.1 - 5.4e-05 23.4 0.1 0.00015 22.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain CbiA PF01656.23 ORX73941.1 - 0.00063 19.8 0.0 0.0015 18.5 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 ORX73941.1 - 0.00083 19.8 0.1 0.0024 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain MobB PF03205.14 ORX73941.1 - 0.00093 19.1 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 ORX73941.1 - 0.0018 18.0 0.0 0.0043 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX73941.1 - 0.0026 18.2 0.0 0.0026 18.2 0.0 2.6 4 0 0 4 4 2 1 AAA domain AAA_22 PF13401.6 ORX73941.1 - 0.0037 17.5 0.1 0.025 14.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 ORX73941.1 - 0.005 16.3 1.8 0.82 9.1 0.1 2.9 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 ORX73941.1 - 0.0068 15.7 0.3 0.024 13.9 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin APS_kinase PF01583.20 ORX73941.1 - 0.0079 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase CLP1_P PF16575.5 ORX73941.1 - 0.0099 15.7 2.4 0.93 9.3 0.1 2.7 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 ORX73941.1 - 0.013 15.4 1.6 0.2 11.5 1.6 2.4 1 1 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 ORX73941.1 - 0.014 15.2 0.1 0.038 13.8 0.1 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 ORX73941.1 - 0.018 14.9 1.4 0.083 12.8 0.1 2.3 1 1 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 ORX73941.1 - 0.021 14.5 0.1 0.056 13.1 0.1 1.7 1 0 0 1 1 1 0 Thymidylate kinase MipZ PF09140.11 ORX73941.1 - 0.024 13.9 1.0 0.65 9.2 1.0 2.3 1 1 0 1 1 1 0 ATPase MipZ AAA_28 PF13521.6 ORX73941.1 - 0.027 14.7 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX73941.1 - 0.029 14.8 0.1 0.31 11.5 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) VirC1 PF07015.11 ORX73941.1 - 0.039 13.2 0.0 0.093 12.0 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein AAA_18 PF13238.6 ORX73941.1 - 0.044 14.3 0.0 0.13 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_26 PF13500.6 ORX73941.1 - 0.054 13.3 0.3 1.4 8.7 0.2 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 ORX73941.1 - 0.055 13.5 0.6 0.31 11.0 0.6 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit 6PF2K PF01591.18 ORX73941.1 - 0.065 12.5 1.1 0.23 10.7 0.0 2.2 3 0 0 3 3 3 0 6-phosphofructo-2-kinase AAA_8 PF12780.7 ORX73941.1 - 0.11 11.8 0.1 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 MMR_HSR1 PF01926.23 ORX73941.1 - 0.17 12.0 0.8 1.4 9.1 0.1 2.8 3 1 0 3 3 2 0 50S ribosome-binding GTPase Brix PF04427.18 ORX73942.1 - 9.3e-29 100.9 0.1 1.5e-28 100.3 0.1 1.3 1 0 0 1 1 1 1 Brix domain SPDY PF03771.16 ORX73942.1 - 0.018 15.0 0.1 6.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF317) Rrn6 PF10214.9 ORX73942.1 - 0.049 12.1 2.1 0.063 11.8 2.1 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SNF2_N PF00176.23 ORX73943.1 - 7.1e-65 219.0 1.1 1.3e-64 218.2 1.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 ORX73943.1 - 2.2e-44 151.0 5.9 2.2e-44 151.0 5.9 1.8 2 0 0 2 2 2 1 DNA-binding domain Helicase_C PF00271.31 ORX73943.1 - 2.3e-15 56.9 0.0 5.1e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX73943.1 - 8.7e-07 29.1 0.0 2.5e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX73943.1 - 4.7e-06 26.0 0.1 0.00011 21.5 0.0 2.7 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 DUF2956 PF11169.8 ORX73943.1 - 7.7 6.8 11.4 1.4 9.1 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Ras PF00071.22 ORX73944.1 - 7.2e-31 107.0 0.0 9.2e-31 106.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX73944.1 - 5.4e-23 81.5 0.0 7.9e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX73944.1 - 6e-08 32.3 0.0 6.7e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX73944.1 - 6.9e-05 22.3 0.0 8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX73944.1 - 0.00047 19.8 0.0 0.014 14.9 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 ORX73944.1 - 0.043 13.0 0.0 2 7.5 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit DLIC PF05783.11 ORX73944.1 - 0.045 12.6 0.0 0.081 11.7 0.0 1.3 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) RAMP4 PF06624.12 ORX73946.1 - 6.8e-05 22.9 0.5 6.8e-05 22.9 0.5 2.6 3 1 1 4 4 4 1 Ribosome associated membrane protein RAMP4 Pox_A6 PF04924.12 ORX73946.1 - 0.069 12.1 0.0 0.091 11.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus A6 protein PMT PF02366.18 ORX73947.1 - 4.7e-79 265.4 15.7 1e-78 264.3 15.7 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX73947.1 - 8.6e-56 188.7 10.7 8.6e-56 188.7 10.7 2.2 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX73947.1 - 5.3e-35 121.0 4.4 1.3e-34 119.6 4.2 1.7 1 1 1 2 2 2 1 MIR domain FHA PF00498.26 ORX73948.1 - 7.6e-21 74.2 0.0 1e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX73948.1 - 4.8e-09 36.4 0.0 5.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF3533 PF12051.8 ORX73950.1 - 1.5e-17 63.6 0.1 1.7e-17 63.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) DUF4246 PF14033.6 ORX73951.1 - 5.6e-116 388.3 0.0 4.1e-106 355.8 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) MFS_1 PF07690.16 ORX73952.1 - 1.9e-44 152.1 45.7 2.3e-44 151.7 45.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX73952.1 - 6.1e-20 71.2 18.1 1e-19 70.5 18.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX73952.1 - 2.9e-12 46.2 14.1 2.9e-12 46.2 14.1 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter Clostridium_P47 PF06597.11 ORX73952.1 - 0.16 10.7 3.0 0.29 9.8 3.0 1.3 1 0 0 1 1 1 0 Clostridium P-47 protein PIRT PF15099.6 ORX73952.1 - 5 6.7 8.2 8.1 6.0 1.3 2.7 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Itfg2 PF15907.5 ORX73954.1 - 7.5e-29 100.8 0.1 2.4e-10 40.0 0.0 4.3 5 0 0 5 5 5 3 Integrin-alpha FG-GAP repeat-containing protein 2 DUF89 PF01937.19 ORX73955.1 - 2.2e-98 329.5 0.1 2.6e-98 329.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 XFP_C PF09363.10 ORX73955.1 - 0.0094 15.4 0.0 0.02 14.3 0.0 1.5 1 0 0 1 1 1 1 XFP C-terminal domain DUF1925 PF09094.11 ORX73955.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) DUF1699 PF08004.11 ORX73955.1 - 0.17 11.6 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) Actin PF00022.19 ORX73956.1 - 2.3e-133 444.8 0.0 2.6e-133 444.6 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ORX73956.1 - 8.3e-07 28.1 0.0 1.3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein RNA_pol_I_A49 PF06870.12 ORX73957.1 - 6e-75 252.5 0.7 1.2e-67 228.5 0.0 2.0 2 0 0 2 2 2 2 A49-like RNA polymerase I associated factor Tae4 PF14113.6 ORX73957.1 - 0.035 14.3 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 PHD PF00628.29 ORX73961.1 - 6.7e-06 25.9 14.1 6.7e-06 25.9 14.1 2.1 2 0 0 2 2 2 1 PHD-finger GATA PF00320.27 ORX73961.1 - 3.5e-05 23.3 5.6 0.0001 21.8 5.6 1.8 1 0 0 1 1 1 1 GATA zinc finger C1_1 PF00130.22 ORX73961.1 - 3.8e-05 23.5 8.6 3.8e-05 23.5 8.6 3.1 3 1 1 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 ORX73961.1 - 0.0084 16.0 9.6 0.0084 16.0 9.6 2.6 2 1 1 3 3 3 1 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 ORX73961.1 - 0.12 12.0 10.4 0.33 10.6 10.3 1.9 1 1 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FAM163 PF15069.6 ORX73961.1 - 0.18 12.3 0.2 0.18 12.3 0.2 2.5 3 0 0 3 3 3 0 FAM163 family zf-RING_2 PF13639.6 ORX73961.1 - 1.4 9.3 14.4 2.3 8.6 12.2 2.6 1 1 1 2 2 2 0 Ring finger domain zf-MYND PF01753.18 ORX73961.1 - 1.8 8.7 15.4 0.49 10.5 5.0 3.7 3 1 0 3 3 3 0 MYND finger Dymeclin PF09742.9 ORX73962.1 - 1.2e-12 47.1 1.1 2.7e-08 32.7 0.4 2.1 2 0 0 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein CBP_BcsO PF17037.5 ORX73962.1 - 2.6 8.1 9.7 0.53 10.4 0.8 3.0 3 1 0 3 3 3 0 Cellulose biosynthesis protein BcsO 2OG-FeII_Oxy_2 PF13532.6 ORX73963.1 - 4.7e-22 79.1 0.0 8.6e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 ORX73963.1 - 3.7e-05 23.5 0.1 8.6e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.23 ORX73964.1 - 4e-92 308.7 3.1 1.7e-65 221.2 0.9 3.2 3 1 1 4 4 4 2 Kinesin motor domain Microtub_bd PF16796.5 ORX73964.1 - 4.2e-19 68.9 1.6 1.1e-18 67.6 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding Filament PF00038.21 ORX73964.1 - 0.0014 18.3 13.3 0.0014 18.3 13.3 4.2 1 1 1 2 2 2 1 Intermediate filament protein DUF465 PF04325.13 ORX73964.1 - 0.0019 18.2 1.9 0.0019 18.2 1.9 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF465) DivIC PF04977.15 ORX73964.1 - 0.0025 17.6 2.2 0.0025 17.6 2.2 7.1 5 2 2 8 8 8 1 Septum formation initiator ADIP PF11559.8 ORX73964.1 - 0.0049 17.0 15.5 0.0049 17.0 15.5 5.3 2 1 3 5 5 5 1 Afadin- and alpha -actinin-Binding AAA_16 PF13191.6 ORX73964.1 - 1.5 9.2 0.0 1.5 9.2 0.0 3.7 4 0 0 4 4 4 0 AAA ATPase domain FPP PF05911.11 ORX73964.1 - 7 4.7 62.1 3.8 5.6 38.1 2.4 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil cobW PF02492.19 ORX73965.1 - 1.1e-31 109.8 0.4 4.4e-30 104.6 0.4 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ORX73965.1 - 0.00026 20.9 0.0 0.00064 19.6 0.0 1.8 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 ORX73965.1 - 0.0022 18.4 0.0 0.0049 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX73965.1 - 0.013 15.5 0.1 0.049 13.7 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 ORX73965.1 - 0.015 15.9 0.2 0.042 14.4 0.1 1.7 1 1 1 2 2 2 0 AAA domain MobB PF03205.14 ORX73965.1 - 0.017 15.0 0.1 0.071 13.0 0.1 2.0 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 ORX73965.1 - 0.037 13.8 0.1 0.1 12.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 ORX73965.1 - 0.043 13.8 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 ORX73965.1 - 0.061 13.8 0.6 0.14 12.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ORX73965.1 - 0.079 12.0 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SRPRB PF09439.10 ORX73965.1 - 0.083 12.3 0.0 0.54 9.7 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ORX73965.1 - 0.11 12.7 0.0 0.34 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ORX73965.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NTPase Peptidase_M28 PF04389.17 ORX73966.1 - 7e-36 123.8 0.0 9.4e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX73966.1 - 1.6e-05 24.7 0.0 4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Pep3_Vps18 PF05131.14 ORX73967.1 - 2.4e-36 124.8 0.0 5.8e-36 123.5 0.0 1.7 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 ORX73967.1 - 5.2e-11 42.6 2.0 1.4e-07 31.5 0.0 3.2 2 1 0 2 2 2 2 Region in Clathrin and VPS Vps39_2 PF10367.9 ORX73967.1 - 1.3e-05 25.6 0.2 3.5e-05 24.2 0.2 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Nup54_57_C PF18570.1 ORX73967.1 - 0.00025 20.6 0.1 0.00081 18.9 0.1 1.9 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain zf-C3H2C3 PF17122.5 ORX73967.1 - 0.033 14.2 5.6 0.11 12.5 5.6 2.0 1 0 0 1 1 1 0 Zinc-finger DUF2175 PF09943.9 ORX73967.1 - 0.11 12.8 0.2 0.33 11.3 0.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) MMS1_N PF10433.9 ORX73967.1 - 0.18 10.4 0.0 3.2 6.3 0.0 1.8 1 1 1 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term HAUS-augmin3 PF14932.6 ORX73967.1 - 0.6 9.6 7.9 1.6 8.3 0.0 3.2 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 zf-RING_5 PF14634.6 ORX73967.1 - 0.76 9.8 5.4 2.2 8.3 5.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ORX73967.1 - 3.2 7.4 11.8 0.069 12.8 4.3 2.1 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type MFS_1 PF07690.16 ORX73968.1 - 6.5e-42 143.7 54.8 8.7e-41 140.0 51.6 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX73968.1 - 9.4e-22 77.2 15.5 1.8e-21 76.3 15.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX73968.1 - 2e-10 40.1 14.8 2e-10 40.1 14.8 2.7 2 0 0 2 2 2 2 Sugar (and other) transporter DUF983 PF06170.12 ORX73968.1 - 4.8 7.7 13.7 2 8.9 0.3 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF983) WD40 PF00400.32 ORX73970.1 - 3.3e-29 100.5 9.8 1.4e-07 32.1 0.3 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73970.1 - 3.8e-14 52.7 0.1 4.5e-05 23.7 0.0 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 ORX73970.1 - 6.1e-12 45.0 0.5 1.1e-11 44.2 0.5 1.4 1 0 0 1 1 1 1 LisH-like dimerisation domain Nup160 PF11715.8 ORX73970.1 - 9.1e-06 24.6 0.4 0.023 13.3 0.1 2.6 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX73970.1 - 1.1e-05 24.6 1.3 0.23 10.4 0.1 3.7 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX73970.1 - 0.0047 16.8 0.0 2.7 7.8 0.0 2.9 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 ORX73970.1 - 0.056 12.4 0.4 1 8.2 0.1 2.4 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 ORX73970.1 - 0.08 12.7 0.2 8.3 6.1 0.1 3.0 3 0 0 3 3 3 0 TUP1-like enhancer of split FOP_dimer PF09398.10 ORX73970.1 - 0.097 12.9 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 FOP N terminal dimerisation domain SprB PF13573.6 ORX73970.1 - 1.1 9.0 3.6 2.1 8.2 1.6 2.4 2 0 0 2 2 2 0 SprB repeat FF PF01846.19 ORX73971.1 - 1e-35 121.7 6.9 1.2e-13 51.0 0.1 6.2 5 1 0 5 5 5 4 FF domain WW PF00397.26 ORX73971.1 - 5.8e-16 58.3 17.9 1.7e-09 37.6 5.0 2.8 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 ORX73971.1 - 0.0062 17.2 11.0 0.17 12.6 0.9 3.6 2 1 1 3 3 3 2 p190-A and -B Rho GAPs FF domain IgG_binding_B PF01378.17 ORX73971.1 - 0.042 13.9 0.1 0.042 13.9 0.1 2.2 2 0 0 2 2 2 0 B domain Med16 PF11635.8 ORX73971.1 - 0.066 11.1 0.2 0.098 10.6 0.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 16 malic PF00390.19 ORX73971.1 - 2.1 8.1 3.9 4.1 7.2 0.4 2.4 1 1 1 2 2 2 0 Malic enzyme, N-terminal domain DUF1367 PF07105.11 ORX73971.1 - 3.5 7.2 9.9 1.2 8.8 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1367) DUF2161 PF09929.9 ORX73971.1 - 3.6 7.7 8.7 0.18 11.9 0.7 2.9 3 0 0 3 3 3 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) IL5 PF02025.15 ORX73971.1 - 7.7 6.8 9.9 0.16 12.2 0.4 2.8 2 1 1 3 3 3 0 Interleukin 5 PSDC PF12588.8 ORX73971.1 - 8.4 6.4 8.7 14 5.7 0.8 3.5 3 1 1 4 4 4 0 Phophatidylserine decarboxylase CSD PF00313.22 ORX73973.1 - 8e-12 44.8 0.1 9.9e-12 44.5 0.1 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ORX73973.1 - 0.00055 19.6 0.1 0.00077 19.1 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease B OB domain EMP70 PF02990.16 ORX73974.1 - 2.3e-194 646.9 12.3 3.6e-194 646.3 12.3 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 DUF4861 PF16153.5 ORX73974.1 - 0.019 13.9 0.1 0.028 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) Mito_carr PF00153.27 ORX73975.1 - 2.8e-65 216.3 0.9 1.2e-23 82.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ORX73975.1 - 0.073 13.4 1.3 0.12 12.8 0.2 1.8 2 0 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family CytB6-F_Fe-S PF08802.10 ORX73975.1 - 3.3 7.8 8.3 0.31 11.1 0.8 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Pkinase PF00069.25 ORX73977.1 - 9.6e-28 97.3 0.0 2.5e-27 95.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX73977.1 - 7e-19 68.1 0.0 1.1e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX73977.1 - 0.0074 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX73977.1 - 0.0093 15.3 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX73977.1 - 0.02 13.9 1.1 0.023 13.6 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX73977.1 - 0.16 10.7 0.3 0.4 9.4 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase PRIMA1 PF16101.5 ORX73977.1 - 3.2 7.8 9.9 0.22 11.6 3.5 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 F-box-like PF12937.7 ORX73979.1 - 0.034 14.1 0.1 0.27 11.1 0.0 2.7 2 0 0 2 2 2 0 F-box-like Herpes_UL52 PF03121.15 ORX73979.1 - 0.13 12.2 0.3 1 9.4 0.2 2.4 2 0 0 2 2 2 0 Herpesviridae UL52/UL70 DNA primase WD40 PF00400.32 ORX73981.1 - 5.4e-09 36.5 0.4 0.17 12.8 0.0 5.4 6 0 0 6 6 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73981.1 - 1.3e-06 28.6 0.0 0.26 11.6 0.0 5.1 1 1 6 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1604 PF07713.13 ORX73981.1 - 0.016 15.0 1.9 0.036 13.9 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) CDC45 PF02724.14 ORX73981.1 - 0.087 11.1 8.2 0.12 10.7 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ORX73981.1 - 0.27 11.6 3.3 0.42 10.9 3.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPA43_OB PF17875.1 ORX73981.1 - 0.89 10.2 3.9 1.9 9.1 3.9 1.5 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Nop14 PF04147.12 ORX73981.1 - 1 7.5 14.2 1.3 7.1 14.2 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ORX73981.1 - 1.1 8.5 16.0 1.9 7.8 16.0 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ORX73981.1 - 1.9 8.9 22.5 6.3 7.3 22.5 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SDA1 PF05285.12 ORX73981.1 - 2.3 7.6 14.3 3.2 7.1 14.3 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ORX73981.1 - 2.9 7.1 14.9 3.9 6.7 14.9 1.1 1 0 0 1 1 1 0 BUD22 PI3K_1B_p101 PF10486.9 ORX73981.1 - 5 4.8 5.9 6.7 4.3 5.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RRN3 PF05327.11 ORX73981.1 - 6.8 5.1 7.9 8.6 4.8 7.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 ORX73981.1 - 8.3 5.4 11.2 13 4.8 11.2 1.2 1 0 0 1 1 1 0 Pes-10 DNA_pol_phi PF04931.13 ORX73981.1 - 8.6 4.3 22.5 12 3.9 22.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ORX73982.1 - 5.6e-26 90.3 13.5 2.9e-06 27.9 0.1 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX73982.1 - 2.5e-05 24.5 1.0 1.9 8.9 0.2 3.8 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain DUF1921 PF09081.10 ORX73982.1 - 0.017 15.3 0.0 1.1 9.5 0.0 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF1921) RRP36 PF06102.12 ORX73983.1 - 2.3e-49 167.6 28.7 2.6e-49 167.4 28.7 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 CCT_2 PF09425.10 ORX73983.1 - 0.012 15.5 2.6 0.012 15.5 2.6 2.2 2 0 0 2 2 2 0 Divergent CCT motif tRNA-synt_1c PF00749.21 ORX73983.1 - 0.017 14.0 4.9 0.019 13.9 4.1 1.5 1 1 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF4404 PF14357.6 ORX73983.1 - 0.67 10.6 7.0 1.5 9.5 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Fib_alpha PF08702.10 ORX73983.1 - 0.79 9.9 7.9 0.89 9.7 6.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 ORX73983.1 - 8.1 5.6 8.2 10 5.3 8.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Ribosomal_L30 PF00327.20 ORX73985.1 - 1.1e-08 34.8 0.1 1.4e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ATE_N PF04376.13 ORX73985.1 - 0.14 12.6 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, N terminus Vma12 PF11712.8 ORX73986.1 - 4.4e-30 104.6 0.0 5.4e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4407 PF14362.6 ORX73986.1 - 0.073 12.4 0.3 0.12 11.7 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Aldo_ket_red PF00248.21 ORX73987.1 - 3.4e-45 154.5 0.0 4.2e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S28e PF01200.18 ORX73988.1 - 1.1e-33 114.9 1.8 1.3e-33 114.8 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Phostensin_N PF13916.6 ORX73988.1 - 0.03 14.7 0.1 0.033 14.5 0.1 1.1 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Chromo PF00385.24 ORX73989.1 - 2.2e-06 27.4 1.3 3.4e-06 26.8 1.3 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Streptin-Immun PF11083.8 ORX73989.1 - 0.14 12.5 0.1 0.25 11.8 0.1 1.3 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein PPR PF01535.20 ORX73991.1 - 6.5e-10 38.6 2.0 0.25 11.7 0.0 5.4 5 0 0 5 5 5 3 PPR repeat PPR_2 PF13041.6 ORX73991.1 - 0.00049 20.2 0.1 4.2 7.6 0.0 4.7 5 0 0 5 5 5 1 PPR repeat family End_beta_propel PF12217.8 ORX73991.1 - 0.0049 15.6 0.0 0.0082 14.9 0.0 1.2 1 0 0 1 1 1 1 Catalytic beta propeller domain of bacteriophage endosialidase PPR_long PF17177.4 ORX73991.1 - 0.013 14.9 0.1 0.064 12.6 0.0 2.2 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP TPR_8 PF13181.6 ORX73991.1 - 0.11 12.7 0.5 1 9.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX73991.1 - 0.12 12.2 0.2 2 8.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4050 PF13259.6 ORX73992.1 - 4.6e-11 43.4 0.3 1e-10 42.3 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF4050) DNA_methylase PF00145.17 ORX73993.1 - 1.6e-27 96.8 0.0 2.7e-26 92.7 0.0 2.0 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase HEAT_2 PF13646.6 ORX73994.1 - 9.3e-27 93.3 0.4 6e-10 39.4 0.0 4.1 1 1 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.16 ORX73994.1 - 2.4e-24 83.5 0.0 0.0039 17.7 0.0 6.5 6 0 0 6 6 6 6 PBS lyase HEAT-like repeat HEAT PF02985.22 ORX73994.1 - 1.9e-09 36.9 4.5 0.15 12.4 0.0 6.0 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 ORX73994.1 - 0.0012 18.9 0.1 0.5 10.4 0.0 3.7 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ORX73994.1 - 0.0013 18.7 0.5 0.6 10.2 0.0 3.2 2 1 1 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX73994.1 - 0.0072 16.8 3.4 8.1 7.1 0.0 4.3 3 2 3 6 6 6 2 HEAT-like repeat Cohesin_HEAT PF12765.7 ORX73994.1 - 0.032 14.5 0.1 0.64 10.4 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion AAA_23 PF13476.6 ORX73995.1 - 1.9e-16 61.1 93.4 4.4e-10 40.4 72.4 6.6 1 1 1 2 2 1 1 AAA domain AAA_15 PF13175.6 ORX73995.1 - 1.8e-12 47.7 16.4 1.6e-07 31.4 0.0 4.5 1 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 ORX73995.1 - 3.2e-12 46.9 0.0 1.2e-05 25.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX73995.1 - 9e-12 44.9 20.4 5.1e-08 32.6 0.0 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ORX73995.1 - 1.2e-05 25.4 0.0 4.2e-05 23.7 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Rad50_zn_hook PF04423.14 ORX73995.1 - 0.0019 18.0 0.0 0.0019 18.0 0.0 4.5 4 0 0 4 4 4 1 Rad50 zinc hook motif ABC_tran PF00005.27 ORX73995.1 - 0.033 14.7 0.0 0.033 14.7 0.0 6.4 3 2 0 4 4 3 0 ABC transporter Flagellin_C PF00700.21 ORX73995.1 - 0.039 14.3 0.3 0.039 14.3 0.3 6.0 5 2 1 6 6 6 0 Bacterial flagellin C-terminal helical region AAA_29 PF13555.6 ORX73995.1 - 0.077 12.8 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 ORX73995.1 - 0.079 12.5 3.1 1.4 8.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain DUF2205 PF10224.9 ORX73995.1 - 0.1 12.6 0.1 0.1 12.6 0.1 7.8 7 1 0 7 7 7 0 Short coiled-coil protein AAA_22 PF13401.6 ORX73995.1 - 0.15 12.3 0.0 0.15 12.3 0.0 4.1 5 1 0 5 5 5 0 AAA domain AAA_16 PF13191.6 ORX73995.1 - 0.27 11.6 0.0 0.27 11.6 0.0 4.3 4 0 0 4 4 4 0 AAA ATPase domain DUF4598 PF15370.6 ORX73996.1 - 1.2e-19 70.8 0.6 2.4e-19 69.8 0.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4598) adh_short PF00106.25 ORX73997.1 - 3e-38 131.3 0.8 3.5e-38 131.0 0.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX73997.1 - 4.2e-27 95.2 0.0 5.2e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ORX73997.1 - 0.00023 20.6 0.1 0.00027 20.4 0.1 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 ORX73997.1 - 0.006 15.8 0.4 0.008 15.3 0.4 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Methyltransf_31 PF13847.6 ORX73997.1 - 0.023 14.5 0.0 0.036 13.9 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 ORX73997.1 - 0.025 14.1 0.6 0.043 13.3 0.6 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Met_10 PF02475.16 ORX73997.1 - 0.059 13.1 0.1 0.076 12.8 0.1 1.2 1 0 0 1 1 1 0 Met-10+ like-protein GDP_Man_Dehyd PF16363.5 ORX73997.1 - 0.21 11.0 0.5 0.27 10.6 0.1 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase AAA PF00004.29 ORX73998.1 - 6.2e-45 152.9 0.0 1.9e-44 151.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX73998.1 - 1.9e-09 37.2 0.0 4.4e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX73998.1 - 8.8e-09 35.5 0.1 2.7e-08 33.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX73998.1 - 1.3e-08 35.2 0.0 2.9e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX73998.1 - 1.9e-08 34.9 0.2 1.6e-05 25.3 0.0 3.0 2 1 0 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 ORX73998.1 - 5.4e-08 32.7 0.2 3.5e-07 30.1 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain DUF815 PF05673.13 ORX73998.1 - 3.3e-05 23.2 0.0 6.3e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ORX73998.1 - 4.5e-05 23.8 1.1 0.01 16.1 0.1 2.9 1 1 1 2 2 2 1 AAA domain TsaE PF02367.17 ORX73998.1 - 0.00015 21.8 0.0 0.012 15.6 0.0 2.4 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ORX73998.1 - 0.00027 21.0 0.0 0.00083 19.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX73998.1 - 0.00045 20.2 0.0 0.0051 16.7 0.0 2.3 2 0 0 2 2 2 1 NTPase RuvB_N PF05496.12 ORX73998.1 - 0.00051 19.8 0.0 0.0015 18.3 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ORX73998.1 - 0.0013 19.3 0.0 0.0036 17.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 ORX73998.1 - 0.0015 18.7 0.0 0.0037 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ORX73998.1 - 0.002 18.5 0.0 0.0041 17.5 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 ORX73998.1 - 0.0022 17.5 0.1 0.018 14.5 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 ORX73998.1 - 0.0038 17.5 0.0 0.0092 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX73998.1 - 0.0047 16.7 0.1 0.013 15.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX73998.1 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX73998.1 - 0.0074 16.0 0.2 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 ORX73998.1 - 0.0087 15.9 0.0 0.028 14.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ORX73998.1 - 0.0093 15.4 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ORX73998.1 - 0.011 15.4 0.6 0.048 13.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain TniB PF05621.11 ORX73998.1 - 0.013 14.9 0.0 0.62 9.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 ORX73998.1 - 0.015 15.3 0.1 0.088 12.7 0.1 2.2 2 0 0 2 2 2 0 NACHT domain TIP49 PF06068.13 ORX73998.1 - 0.017 14.3 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activat PF00158.26 ORX73998.1 - 0.019 14.7 0.1 0.23 11.1 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 ORX73998.1 - 0.036 13.4 0.0 0.5 9.7 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 ORX73998.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX73998.1 - 0.041 14.2 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF3666 PF12408.8 ORX73998.1 - 0.086 12.1 0.0 0.35 10.1 0.0 2.1 1 0 0 1 1 1 0 Ribose-5-phosphate isomerase ABC_tran PF00005.27 ORX73998.1 - 0.089 13.3 0.1 0.34 11.4 0.0 2.1 2 1 0 2 2 1 0 ABC transporter Parvo_NS1 PF01057.17 ORX73998.1 - 0.13 11.3 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_29 PF13555.6 ORX73998.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Nop PF01798.18 ORX73999.1 - 6.1e-68 228.7 0.1 9.5e-68 228.1 0.1 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ORX73999.1 - 2.4e-34 118.8 4.7 5.1e-34 117.8 4.7 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain Sfi1 PF08457.10 ORX74002.1 - 5.8e-05 21.8 9.3 0.00077 18.1 0.6 6.0 4 2 2 6 6 6 3 Sfi1 spindle body protein Adap_comp_sub PF00928.21 ORX74003.1 - 8.7e-92 307.2 0.1 1.1e-91 306.9 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX74003.1 - 7.2e-07 29.2 0.1 1.5e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ORX74003.1 - 0.0026 17.3 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF4897 PF16238.5 ORX74003.1 - 0.3 10.9 1.8 1.5 8.6 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4897) Hydrolase_4 PF12146.8 ORX74004.1 - 1.3e-54 185.0 0.1 1.6e-54 184.8 0.1 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74004.1 - 1e-18 68.0 0.0 2.9e-14 53.3 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX74004.1 - 4.5e-11 43.8 0.0 5.5e-11 43.5 0.0 1.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 ORX74004.1 - 0.00011 22.4 0.0 0.00067 19.8 0.0 2.1 2 0 0 2 2 2 1 Thioesterase domain Peptidase_S9 PF00326.21 ORX74004.1 - 0.0022 17.5 0.3 0.35 10.3 0.1 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family LIDHydrolase PF10230.9 ORX74004.1 - 0.006 16.2 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Esterase PF00756.20 ORX74004.1 - 0.0072 16.0 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 ORX74004.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.13 ORX74004.1 - 0.029 14.2 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Asp2 PF16929.5 ORX74004.1 - 0.055 12.4 0.0 7.7 5.4 0.0 2.1 2 0 0 2 2 2 0 Accessory Sec system GspB-transporter Abhydrolase_5 PF12695.7 ORX74004.1 - 0.096 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF915 PF06028.11 ORX74004.1 - 0.16 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) LIM_bind PF01803.16 ORX74005.1 - 2.2e-18 66.7 0.6 9.1e-17 61.4 0.0 2.9 3 0 0 3 3 3 1 LIM-domain binding protein Abhydrolase_3 PF07859.13 ORX74006.1 - 1.7e-12 47.7 0.2 2.4e-12 47.1 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX74006.1 - 6.4e-10 38.9 0.1 8.8e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ORX74006.1 - 2.1e-08 33.5 0.1 5.1e-08 32.2 0.1 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 ORX74006.1 - 2e-05 25.3 1.1 4.9e-05 24.0 1.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX74006.1 - 2.8e-05 23.9 0.5 9.3e-05 22.2 0.5 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 ORX74007.1 - 0.00012 21.1 0.0 0.00016 20.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX74007.1 - 0.0017 18.3 0.1 0.002 18.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX74007.1 - 0.088 11.7 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase MIT PF04212.18 ORX74008.1 - 0.00091 19.2 0.2 0.0032 17.5 0.1 2.0 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain zf-CCHC_3 PF13917.6 ORX74010.1 - 2.6e-08 33.7 0.2 2.6e-08 33.7 0.2 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 ORX74010.1 - 0.00058 19.8 2.6 0.0011 19.0 2.6 1.5 1 0 0 1 1 1 1 Zinc knuckle Macoilin PF09726.9 ORX74010.1 - 0.21 10.1 13.6 0.23 10.0 13.6 1.0 1 0 0 1 1 1 0 Macoilin family DUF755 PF05501.11 ORX74010.1 - 3.6 7.9 44.0 0.049 13.9 17.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF755) GDA1_CD39 PF01150.17 ORX74011.1 - 1.3e-106 356.8 0.0 1.6e-106 356.5 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 ORX74011.1 - 0.0011 18.5 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family BSD PF03909.17 ORX74012.1 - 1.5e-09 37.7 1.6 2.5e-09 37.0 0.2 2.1 2 0 0 2 2 2 1 BSD domain Complex1_30kDa PF00329.19 ORX74013.1 - 6.6e-42 143.0 0.0 8.7e-42 142.6 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit eRF1_2 PF03464.15 ORX74014.1 - 7.9e-44 149.2 0.0 1.3e-43 148.5 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ORX74014.1 - 8.5e-38 129.3 0.1 1.8e-37 128.2 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 ORX74014.1 - 5e-20 71.8 0.0 9.6e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 ORX74014.1 - 2.9e-09 37.3 0.0 5.3e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 ORX74014.1 - 2.9e-09 37.3 0.0 4.6e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Methyltransf_16 PF10294.9 ORX74015.1 - 1.5e-21 76.9 0.1 2.2e-21 76.4 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase FAM86 PF14904.6 ORX74015.1 - 3.6e-06 27.0 0.1 9.8e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function PrmA PF06325.13 ORX74015.1 - 0.0019 17.7 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ORX74015.1 - 0.0039 17.8 0.0 0.0091 16.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX74015.1 - 0.0064 16.3 0.1 0.0099 15.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX74015.1 - 0.031 13.9 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 ORX74015.1 - 0.05 13.2 0.1 0.082 12.5 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ORX74015.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) WD40 PF00400.32 ORX74016.1 - 2.3e-32 110.5 18.0 8.4e-05 23.3 0.6 8.2 7 1 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ORX74016.1 - 8.9e-10 38.3 0.9 2e-09 37.2 0.1 1.9 2 0 0 2 2 2 1 F-box-like Nup160 PF11715.8 ORX74016.1 - 2.8e-09 36.2 5.8 0.024 13.3 0.0 5.2 2 2 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX74016.1 - 8.6e-09 35.1 0.4 1.2e-05 24.8 0.0 2.1 2 0 0 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ORX74016.1 - 4.2e-08 33.2 0.1 0.018 15.1 0.0 3.7 2 1 1 3 3 3 3 Ciliary BBSome complex subunit 2, middle region F-box PF00646.33 ORX74016.1 - 1.2e-07 31.5 0.1 3e-07 30.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ORX74016.1 - 4e-06 27.0 0.8 4.8 7.6 0.1 5.2 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ORX74016.1 - 4e-05 24.0 1.7 0.88 10.2 0.3 4.5 4 1 0 4 4 4 2 PQQ-like domain F-box_4 PF15966.5 ORX74016.1 - 0.002 18.0 0.4 0.1 12.5 0.0 2.7 2 0 0 2 2 2 1 F-box PALB2_WD40 PF16756.5 ORX74016.1 - 0.22 10.4 1.4 20 4.0 0.0 2.9 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain CAP PF00188.26 ORX74018.1 - 1.1e-09 39.2 0.0 1.6e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Staphylcoagulse PF04022.12 ORX74018.1 - 0.15 11.6 2.1 11 5.6 1.6 2.5 2 0 0 2 2 2 0 Staphylocoagulase repeat CAP PF00188.26 ORX74019.1 - 3.7e-09 37.5 0.0 5.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PMSR PF01625.21 ORX74020.1 - 6.8e-61 204.9 2.4 8.5e-61 204.6 2.4 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Galactosyl_T PF01762.21 ORX74021.1 - 7.1e-05 22.7 0.2 0.002 18.0 0.2 2.1 1 1 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 ORX74021.1 - 0.014 14.9 0.1 0.36 10.3 0.0 2.5 3 0 0 3 3 3 0 Glycosyl transferase family 21 zf-C2HE PF16278.5 ORX74021.1 - 0.41 11.1 2.3 9.5 6.8 0.1 2.8 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Galactosyl_T PF01762.21 ORX74022.1 - 0.0002 21.2 0.3 0.0051 16.6 0.3 2.1 1 1 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 ORX74022.1 - 0.0012 18.4 0.0 1.4 8.4 0.0 2.2 1 1 1 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX74022.1 - 0.085 12.7 0.2 0.16 11.8 0.2 1.5 1 1 0 1 1 1 0 Glycosyl transferase family 2 Galactosyl_T PF01762.21 ORX74023.1 - 9.8e-05 22.2 1.3 0.0019 18.0 1.3 2.0 1 1 0 1 1 1 1 Galactosyltransferase His_Phos_2 PF00328.22 ORX74024.1 - 1.3e-75 255.2 0.0 1.6e-75 254.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 ORX74024.1 - 3.2e-31 107.3 0.0 7.6e-31 106.1 0.0 1.7 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 ORX74024.1 - 2.3e-09 37.1 0.1 4.1e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Ins134_P3_kin PF05770.11 ORX74024.1 - 0.068 12.7 0.1 0.44 10.0 0.0 2.1 1 1 1 2 2 2 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Nipped-B_C PF12830.7 ORX74024.1 - 0.18 11.7 0.9 0.39 10.6 0.9 1.6 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus GTP1_OBG PF01018.22 ORX74026.1 - 3e-45 153.6 0.6 4e-45 153.2 0.6 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 ORX74026.1 - 5.1e-23 81.3 0.0 9.4e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX74026.1 - 1.1e-11 44.5 0.0 2.5e-11 43.4 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 ORX74026.1 - 1.5e-05 24.5 0.0 2.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MeaB PF03308.16 ORX74026.1 - 0.00027 20.0 0.2 0.64 8.9 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Ras PF00071.22 ORX74026.1 - 0.0034 17.0 0.0 0.0059 16.2 0.0 1.4 1 1 0 1 1 1 1 Ras family MMR_HSR1_Xtn PF16897.5 ORX74026.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 ORX74026.1 - 0.026 14.6 0.0 7.8 6.5 0.0 2.2 1 1 1 2 2 2 0 Dynamin family ATP_bind_1 PF03029.17 ORX74026.1 - 0.11 12.3 0.0 8.9 6.0 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 ORX74026.1 - 0.23 12.0 0.5 0.78 10.3 0.0 2.1 2 1 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.27 ORX74027.1 - 1.8e-62 210.3 0.1 3.5e-62 209.4 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 ORX74027.1 - 2.2e-27 94.9 0.0 5.2e-27 93.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ORX74027.1 - 7.4e-20 70.8 0.0 1.9e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX74027.1 - 3.5e-09 36.9 0.1 1e-08 35.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 ORX74027.1 - 9.3e-07 28.7 0.0 0.0083 15.9 0.0 2.7 2 0 0 2 2 2 2 Elongation factor G, domain IV RF3_C PF16658.5 ORX74027.1 - 2.1e-05 24.4 0.0 4.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ORX74027.1 - 0.00046 20.3 0.0 0.0013 18.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX74027.1 - 0.041 13.4 0.0 0.094 12.2 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B F-box-like PF12937.7 ORX74028.1 - 0.051 13.5 0.3 0.084 12.8 0.3 1.4 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 ORX74029.1 - 0.021 15.2 5.7 1.9 9.0 0.2 3.0 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) AAA PF00004.29 ORX74031.1 - 9.8e-14 51.9 0.0 2.1e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX74031.1 - 5.5e-06 26.9 0.3 0.0012 19.3 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX74031.1 - 5.9e-06 26.6 0.1 0.00018 21.8 0.1 2.6 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 ORX74031.1 - 9.9e-06 25.6 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 ORX74031.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX74031.1 - 0.0002 21.3 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ORX74031.1 - 0.00062 19.8 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX74031.1 - 0.00075 19.7 0.1 0.0027 17.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 ORX74031.1 - 0.0022 17.7 0.1 0.0048 16.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX74031.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 ORX74031.1 - 0.018 14.7 0.1 0.07 12.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 ORX74031.1 - 0.02 14.7 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ORX74031.1 - 0.023 15.2 0.0 0.095 13.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 ORX74031.1 - 0.028 14.3 0.1 0.23 11.4 0.1 2.3 1 1 1 2 2 2 0 NACHT domain NB-ARC PF00931.22 ORX74031.1 - 0.043 13.0 0.0 0.089 12.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 ORX74031.1 - 0.06 13.3 0.2 0.21 11.5 0.1 1.9 1 1 1 2 2 2 0 NTPase ABC_tran PF00005.27 ORX74031.1 - 0.065 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 ORX74031.1 - 0.067 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 ORX74031.1 - 0.075 13.5 0.1 0.19 12.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX74031.1 - 0.075 13.4 0.1 0.25 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ORX74031.1 - 0.098 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 ORX74031.1 - 0.099 13.0 0.0 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_2 PF07724.14 ORX74031.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 ORX74031.1 - 0.14 11.6 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ORX74031.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_assoc_2 PF16193.5 ORX74031.1 - 0.18 12.2 0.3 0.49 10.8 0.1 1.9 2 0 0 2 2 1 0 AAA C-terminal domain NMT PF01233.19 ORX74032.1 - 7.3e-68 227.4 0.0 1.6e-67 226.3 0.0 1.6 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 ORX74032.1 - 2.2e-59 200.5 0.0 3.7e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 ORX74032.1 - 8.4e-06 25.9 0.1 6.1e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX74032.1 - 3.8e-05 23.9 0.1 0.015 15.5 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Mak10 PF04112.13 ORX74032.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Ion_trans PF00520.31 ORX74033.1 - 0.0072 15.6 0.6 0.0091 15.3 0.6 1.1 1 0 0 1 1 1 1 Ion transport protein Glyco_transf_22 PF03901.17 ORX74035.1 - 3.5e-83 280.2 20.5 4.1e-83 279.9 20.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF962 PF06127.11 ORX74035.1 - 0.57 10.3 5.6 0.75 9.9 1.2 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Pkinase PF00069.25 ORX74036.1 - 8.8e-65 218.7 0.0 1e-64 218.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74036.1 - 2.5e-22 79.4 0.0 3.5e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX74036.1 - 0.00071 19.6 0.1 0.023 14.6 0.0 2.4 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX74036.1 - 0.0041 16.5 0.0 0.026 13.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 ORX74036.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX74036.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX74036.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 BIRC6 PF12356.8 ORX74037.1 - 0.13 11.7 0.9 0.24 10.8 0.9 1.3 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 Ribonuc_P_40 PF08584.11 ORX74038.1 - 1e-55 189.1 0.0 1.3e-55 188.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit ETF_QO PF05187.13 ORX74039.1 - 2.2e-50 169.1 0.4 4.2e-50 168.2 0.4 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Thi4 PF01946.17 ORX74039.1 - 5.8e-10 38.8 0.1 5.5e-05 22.5 0.2 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.24 ORX74039.1 - 3e-09 36.5 1.0 2.6e-05 23.5 1.8 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ORX74039.1 - 9.9e-09 35.2 1.4 5.1e-06 26.3 0.4 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX74039.1 - 1.6e-07 30.8 0.1 4.8e-07 29.3 0.1 1.6 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX74039.1 - 2.1e-06 27.9 0.1 8.6e-06 25.9 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ORX74039.1 - 8.6e-06 25.3 0.0 1.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX74039.1 - 4.1e-05 22.5 0.9 0.00016 20.6 0.9 1.8 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 ORX74039.1 - 0.00013 21.1 0.3 0.0002 20.6 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 ORX74039.1 - 0.00016 20.7 0.1 0.0057 15.6 0.4 2.1 1 1 1 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 ORX74039.1 - 0.00024 21.1 0.3 0.00048 20.1 0.3 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ORX74039.1 - 0.00029 20.2 0.1 0.00068 19.0 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ORX74039.1 - 0.00037 21.0 1.2 1.1 9.9 0.5 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 ORX74039.1 - 0.0012 19.4 1.2 0.0028 18.2 1.2 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Pyr_redox_3 PF13738.6 ORX74039.1 - 0.0016 17.8 0.6 0.0023 17.2 0.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.6 ORX74039.1 - 0.07 13.3 0.7 0.17 12.0 0.7 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain GIDA PF01134.22 ORX74039.1 - 0.073 12.1 1.1 0.11 11.6 1.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 ORX74039.1 - 0.097 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) MutL PF13941.6 ORX74039.1 - 0.1 11.2 0.1 0.18 10.4 0.1 1.3 1 0 0 1 1 1 0 MutL protein Fer4_2 PF12797.7 ORX74039.1 - 0.1 12.8 0.6 0.25 11.5 0.6 1.6 1 0 0 1 1 1 0 4Fe-4S binding domain YycC PF14174.6 ORX74040.1 - 0.035 13.9 0.2 0.09 12.6 0.2 1.7 1 0 0 1 1 1 0 YycC-like protein ATP-synt_D PF01813.17 ORX74041.1 - 1.3e-70 237.2 3.2 1.5e-70 237.0 3.2 1.0 1 0 0 1 1 1 1 ATP synthase subunit D UCH PF00443.29 ORX74043.1 - 3.4e-48 164.4 0.0 4.2e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX74043.1 - 5.8e-14 52.4 0.0 2e-12 47.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ORX74043.1 - 1.5e-12 47.0 0.1 3.5e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family FMN_dh PF01070.18 ORX74044.1 - 2.8e-130 434.4 0.0 3.4e-130 434.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ORX74044.1 - 7.4e-06 25.2 1.2 1.5e-05 24.2 1.1 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 ORX74044.1 - 0.00011 21.6 0.5 0.71 9.1 0.1 3.0 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 ORX74044.1 - 0.00012 21.3 0.1 0.0002 20.6 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 ORX74044.1 - 0.0017 17.8 0.9 0.0032 16.9 0.9 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ORX74044.1 - 0.013 15.0 0.1 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein Clathrin PF00637.20 ORX74045.1 - 6.1e-26 91.0 0.2 1.4e-25 89.9 0.2 1.6 1 0 0 1 1 1 1 Region in Clathrin and VPS zf-RING_11 PF17123.5 ORX74045.1 - 0.0017 18.0 1.4 0.0045 16.7 1.4 1.7 1 0 0 1 1 1 1 RING-like zinc finger ANAPC4_WD40 PF12894.7 ORX74045.1 - 0.0049 17.2 0.1 2.3 8.6 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Vps39_2 PF10367.9 ORX74045.1 - 0.0094 16.4 0.0 0.018 15.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.6 ORX74045.1 - 0.013 15.8 0.9 0.013 15.8 0.9 2.0 2 0 0 2 2 2 0 Ring finger domain WD40 PF00400.32 ORX74045.1 - 0.014 16.2 0.0 0.042 14.7 0.0 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 ORX74045.1 - 0.02 14.5 3.9 0.032 13.9 0.3 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 ORX74045.1 - 0.03 14.6 0.4 0.087 13.1 0.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Vps39_1 PF10366.9 ORX74045.1 - 0.064 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 1 zf-RING_UBOX PF13445.6 ORX74045.1 - 0.21 11.6 1.6 0.46 10.5 1.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX74045.1 - 0.84 9.5 5.5 0.086 12.7 1.0 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX74045.1 - 7.7 6.6 5.3 0.72 9.9 0.6 1.8 2 1 0 2 2 1 0 zinc-RING finger domain Transthyretin PF00576.21 ORX74046.1 - 0.04 14.6 0.0 0.058 14.1 0.0 1.2 1 0 0 1 1 1 0 HIUase/Transthyretin family Lipase_3 PF01764.25 ORX74048.1 - 9e-40 135.8 0.0 1.3e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX74048.1 - 2.6e-06 27.2 0.1 6.5e-06 25.9 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 ORX74048.1 - 0.00025 20.8 0.0 0.00099 18.8 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX74048.1 - 0.0017 19.0 0.0 0.0024 18.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 ORX74048.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 ORX74048.1 - 0.04 13.6 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF4827 PF16109.5 ORX74048.1 - 0.062 13.3 0.2 0.096 12.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) Hydrolase_4 PF12146.8 ORX74048.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Yeast_MT PF11403.8 ORX74048.1 - 0.19 12.3 0.3 0.19 12.3 0.3 1.9 2 0 0 2 2 2 0 Yeast metallothionein Cu-oxidase_3 PF07732.15 ORX74049.1 - 3.9e-39 133.3 3.5 7.7e-33 113.0 0.3 4.4 4 1 0 4 4 4 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX74049.1 - 8.9e-36 122.6 7.4 1.9e-31 108.6 0.9 2.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX74049.1 - 2.3e-25 89.6 0.0 5.6e-22 78.6 0.0 3.1 3 0 0 3 3 3 2 Multicopper oxidase Keratin_2_head PF16208.5 ORX74050.1 - 0.78 9.9 17.2 1.1 9.4 17.2 1.2 1 0 0 1 1 1 0 Keratin type II head DnaJ PF00226.31 ORX74051.1 - 1.5e-12 47.4 0.1 5e-12 45.8 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain BRO1 PF03097.18 ORX74052.1 - 4.3e-109 364.9 0.1 8.6e-109 363.9 0.1 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ORX74052.1 - 3.5e-59 200.5 7.2 3.5e-59 200.5 7.2 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF2972 PF11186.8 ORX74052.1 - 0.14 12.0 2.9 2.2 8.1 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2972) Syntaxin_2 PF14523.6 ORX74052.1 - 1.8 9.0 4.5 4.2 7.8 0.2 2.9 2 1 1 3 3 3 0 Syntaxin-like protein Dus PF01207.17 ORX74053.1 - 2.5e-76 256.7 0.0 4.6e-76 255.9 0.0 1.3 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) SOR_SNZ PF01680.17 ORX74053.1 - 1.5e-05 24.9 0.8 0.0013 18.6 0.2 2.2 1 1 1 2 2 2 2 SOR/SNZ family NMO PF03060.15 ORX74053.1 - 0.00095 18.6 0.1 0.0038 16.6 0.1 1.8 1 1 1 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 ORX74053.1 - 0.04 13.4 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein G3P_antiterm PF04309.12 ORX74053.1 - 0.069 12.6 0.1 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator TMP-TENI PF02581.17 ORX74053.1 - 0.12 11.6 0.1 0.25 10.6 0.1 1.5 1 0 0 1 1 1 0 Thiamine monophosphate synthase Adenylsucc_synt PF00709.21 ORX74054.1 - 5.5e-181 602.1 0.0 6.2e-181 601.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase AA_permease PF00324.21 ORX74055.1 - 3.9e-104 348.9 46.3 1.1e-101 340.9 46.3 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX74055.1 - 3.1e-24 85.6 44.0 3.3e-20 72.3 44.0 2.1 1 1 0 1 1 1 1 Amino acid permease Sec7 PF01369.20 ORX74058.1 - 3.9e-27 95.1 0.0 6.3e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ORX74059.1 - 4.8e-30 104.4 0.0 5.6e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX74059.1 - 7.5e-09 36.0 0.0 9.7e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 PH domain 2OG-FeII_Oxy_2 PF13532.6 ORX74059.1 - 0.025 14.8 0.0 0.031 14.5 0.0 1.1 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily YCII PF03795.14 ORX74059.1 - 0.17 12.3 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 YCII-related domain NAD_kinase PF01513.21 ORX74060.1 - 8.2e-76 255.0 0.0 1e-75 254.7 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ORX74060.1 - 0.076 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DNAP_B_exo_N PF08452.10 ORX74060.1 - 0.27 10.7 2.3 0.5 9.8 2.3 1.4 1 0 0 1 1 1 0 DNA polymerase family B exonuclease domain, N-terminal DNA_pol_phi PF04931.13 ORX74060.1 - 8 4.4 5.7 9.9 4.1 5.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi UreD PF01774.17 ORX74061.1 - 3.7e-51 174.1 0.0 4.2e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein Ribosomal_L34 PF00468.17 ORX74062.1 - 1.7e-10 40.7 10.2 4.8e-05 23.2 2.8 2.2 2 1 0 2 2 2 2 Ribosomal protein L34 zf-C2H2 PF00096.26 ORX74064.1 - 2.4e-13 49.7 16.2 0.00029 21.1 2.3 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX74064.1 - 3.1e-12 46.3 7.8 1.6e-08 34.6 0.9 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX74064.1 - 2.3e-11 43.5 14.5 0.00097 19.8 1.5 3.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX74064.1 - 5.1e-10 39.4 8.9 0.0022 18.3 0.0 3.1 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX74064.1 - 7.4e-06 26.2 9.5 0.095 13.1 0.7 3.1 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ORX74064.1 - 1.3e-05 25.1 11.3 0.3 11.1 1.4 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX74064.1 - 0.00034 20.3 6.7 0.091 12.5 0.4 2.6 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2HE PF16278.5 ORX74064.1 - 0.041 14.3 9.1 0.66 10.5 4.1 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 ORX74064.1 - 0.044 13.7 6.4 9 6.3 0.0 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger BolA PF01722.18 ORX74064.1 - 0.045 14.0 0.5 0.058 13.7 0.5 1.3 1 0 0 1 1 1 0 BolA-like protein C1_4 PF07975.12 ORX74064.1 - 0.1 12.9 4.8 0.35 11.1 4.8 1.8 1 1 0 1 1 1 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 ORX74064.1 - 0.11 12.4 1.1 0.11 12.4 1.1 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-AN1 PF01428.16 ORX74064.1 - 0.21 11.8 9.2 0.73 10.0 3.2 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Elf1 PF05129.13 ORX74064.1 - 0.89 9.6 6.2 27 4.9 6.4 2.0 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 ORX74064.1 - 0.93 9.6 8.2 8.3 6.5 1.6 3.0 1 1 2 3 3 3 0 BED zinc finger GAGA PF09237.11 ORX74064.1 - 1.5 8.7 5.6 0.14 11.9 0.8 1.7 1 1 1 2 2 2 0 GAGA factor Bromodomain PF00439.25 ORX74066.1 - 9.3e-57 189.1 0.0 7.7e-20 70.8 0.0 3.7 3 0 0 3 3 3 3 Bromodomain Peptidase_M1_N PF17900.1 ORX74066.1 - 1.3e-05 25.5 0.0 3.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 ORX74066.1 - 3.9e-05 23.3 0.0 7.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Ntox28 PF15605.6 ORX74066.1 - 0.11 12.8 0.0 0.38 11.0 0.0 1.9 1 0 0 1 1 1 0 Bacterial toxin 28 DUF4443 PF14544.6 ORX74066.1 - 0.12 12.7 0.0 25 5.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4443) HEAT_2 PF13646.6 ORX74066.1 - 0.51 10.8 2.3 5.3 7.5 0.3 2.7 2 0 0 2 2 2 0 HEAT repeats MOZART1 PF12554.8 ORX74068.1 - 6.3e-07 29.1 0.3 7.5e-07 28.8 0.3 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated UPF0154 PF03672.13 ORX74068.1 - 0.14 12.2 1.0 0.17 12.0 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Ribosomal_L37e PF01907.19 ORX74069.1 - 4.6e-26 90.7 13.1 6.7e-26 90.2 13.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 ORX74069.1 - 0.0077 16.2 1.3 0.011 15.7 1.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.18 ORX74069.1 - 0.023 14.8 0.5 0.024 14.7 0.5 1.2 1 0 0 1 1 1 0 SelR domain HypA PF01155.19 ORX74069.1 - 0.058 13.4 0.6 0.078 13.0 0.6 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4 PF00097.25 ORX74069.1 - 0.3 11.0 5.0 0.47 10.4 5.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zn-ribbon_14 PF16503.5 ORX74069.1 - 1.6 8.3 6.0 1.8 8.2 0.3 2.2 2 0 0 2 2 2 0 Zinc-ribbon Homeodomain PF00046.29 ORX74070.1 - 5e-19 67.9 4.2 5.3e-19 67.8 4.2 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX74070.1 - 5.5e-05 23.0 0.8 0.0001 22.2 0.8 1.4 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 ORX74070.1 - 0.0086 15.9 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_23 PF13384.6 ORX74070.1 - 0.021 14.6 0.1 0.034 13.9 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain MnmE_helical PF12631.7 ORX74072.1 - 5.3e-49 167.2 0.3 6.9e-49 166.8 0.3 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 ORX74072.1 - 6e-35 120.0 0.0 1.6e-34 118.6 0.0 1.8 2 0 0 2 2 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 ORX74072.1 - 2.1e-20 72.9 0.0 4.5e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX74072.1 - 8.4e-07 28.6 0.0 2.2e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX74072.1 - 4.9e-05 23.5 0.0 9.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 ORX74072.1 - 0.00048 20.1 0.0 0.032 14.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase Arf PF00025.21 ORX74072.1 - 0.0015 18.0 0.0 0.0062 16.0 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_28 PF13521.6 ORX74072.1 - 0.0023 18.2 0.0 0.0066 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX74072.1 - 0.0062 16.8 0.0 0.23 11.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX74072.1 - 0.013 15.9 0.3 0.04 14.3 0.3 2.0 1 1 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.27 ORX74072.1 - 0.017 14.6 0.1 0.95 9.0 0.0 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_35 PF14516.6 ORX74072.1 - 0.026 13.4 0.0 0.048 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.6 ORX74072.1 - 0.028 14.6 0.0 0.22 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX74072.1 - 0.029 14.9 0.0 0.062 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ORX74072.1 - 0.03 14.9 0.1 0.26 11.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ORX74072.1 - 0.091 12.3 0.0 1.4 8.5 0.0 2.2 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NAD_Gly3P_dh_C PF07479.14 ORX74072.1 - 0.099 12.9 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus AAA_29 PF13555.6 ORX74072.1 - 0.14 11.9 0.0 0.42 10.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain IF3_C PF00707.22 ORX74073.1 - 1.1e-11 44.6 0.2 1.8e-11 43.8 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 ORX74073.1 - 6.2e-08 32.8 0.1 2.2e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain Pep_M12B_propep PF01562.19 ORX74073.1 - 0.0038 17.5 0.2 0.0057 16.9 0.2 1.2 1 0 0 1 1 1 1 Reprolysin family propeptide MFS_2 PF13347.6 ORX74074.1 - 1.4e-08 33.8 4.2 1.4e-08 33.8 4.2 2.5 2 1 0 2 2 2 1 MFS/sugar transport protein IncF PF17626.2 ORX74074.1 - 0.067 13.5 1.1 0.27 11.6 0.1 2.3 2 0 0 2 2 2 0 Inclusion membrane protein F MTHFR PF02219.17 ORX74075.1 - 1.6e-93 313.2 0.0 2.3e-93 312.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase MINDY_DUB PF04424.13 ORX74076.1 - 2e-25 89.1 0.0 3.4e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase Spt20 PF12090.8 ORX74076.1 - 0.18 11.4 8.6 0.36 10.4 8.6 1.4 1 0 0 1 1 1 0 Spt20 family SUIM_assoc PF16619.5 ORX74076.1 - 0.65 10.1 11.5 2.4 8.3 11.5 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 ORX74077.1 - 3.8e-31 108.4 0.0 1.8e-14 53.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74077.1 - 6.9e-20 71.4 0.0 1.4e-10 40.9 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Nucleocapsid-N PF11030.8 ORX74077.1 - 1.6 8.6 3.9 3.1 7.7 3.9 1.3 1 0 0 1 1 1 0 Nucleocapsid protein N ATP_sub_h PF10775.9 ORX74079.1 - 0.11 12.5 0.9 0.2 11.6 0.3 1.7 1 1 1 2 2 2 0 ATP synthase complex subunit h MMR_HSR1 PF01926.23 ORX74080.1 - 6.9e-17 61.6 0.0 4.9e-13 49.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX74080.1 - 4.6e-06 26.6 0.2 0.025 14.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX74080.1 - 7.3e-06 25.7 0.2 0.05 13.1 0.0 3.0 2 1 1 3 3 3 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX74080.1 - 1.4e-05 24.6 0.1 0.00059 19.4 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 ORX74080.1 - 0.0019 17.6 0.1 0.0068 15.8 0.1 1.9 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 ORX74080.1 - 0.0024 17.9 0.7 0.0077 16.3 0.0 2.3 3 0 0 3 3 3 1 Dynamin family Septin PF00735.18 ORX74080.1 - 0.088 12.1 0.3 1.1 8.5 0.0 2.5 3 0 0 3 3 3 0 Septin MeaB PF03308.16 ORX74080.1 - 0.11 11.4 0.9 0.49 9.3 0.1 2.3 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 ORX74080.1 - 0.12 12.6 1.4 1.9 8.7 0.0 3.3 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase zf-C2H2 PF00096.26 ORX74081.1 - 2.8e-13 49.5 9.6 1.8e-06 28.1 3.0 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX74081.1 - 8.4e-11 41.8 8.9 2e-05 25.0 2.5 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX74081.1 - 5.5e-10 39.2 12.5 3.4e-09 36.7 1.4 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX74081.1 - 4.1e-06 26.7 5.4 0.00079 19.4 0.2 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger Rad50_zn_hook PF04423.14 ORX74081.1 - 2.4e-05 24.1 2.4 0.049 13.5 0.2 2.1 2 0 0 2 2 2 2 Rad50 zinc hook motif zf-C2H2_11 PF16622.5 ORX74081.1 - 5.9e-05 22.7 4.3 0.03 14.1 0.3 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ORX74081.1 - 0.00017 21.8 1.7 0.18 12.2 0.7 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 ORX74081.1 - 0.0003 20.6 3.0 0.0003 20.6 3.0 2.7 2 1 0 2 2 2 1 zinc-finger of a C2HC-type YacG PF03884.14 ORX74081.1 - 0.0015 18.2 0.7 0.97 9.2 0.1 2.2 2 0 0 2 2 2 2 DNA gyrase inhibitor YacG Zn-C2H2_12 PF18112.1 ORX74081.1 - 0.0021 18.5 4.9 0.18 12.3 2.4 2.6 2 1 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain Zn-ribbon_8 PF09723.10 ORX74081.1 - 0.0024 17.9 2.7 0.005 16.9 2.6 1.6 1 1 0 1 1 1 1 Zinc ribbon domain TRAF6_Z2 PF18048.1 ORX74081.1 - 0.0024 17.9 2.9 0.33 11.1 0.6 2.4 2 0 0 2 2 2 1 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_9 PF16293.5 ORX74081.1 - 0.0032 17.3 0.8 0.4 10.6 0.1 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 ORX74081.1 - 0.0035 17.6 3.1 0.0095 16.2 3.1 1.7 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 ORX74081.1 - 0.0036 16.8 3.0 0.49 10.0 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-TFIIB PF13453.6 ORX74081.1 - 0.0036 16.6 4.1 0.0036 16.6 4.1 1.5 1 1 0 1 1 1 1 Transcription factor zinc-finger Prok-RING_1 PF14446.6 ORX74081.1 - 0.004 17.1 1.4 0.94 9.5 0.1 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-C2HE PF16278.5 ORX74081.1 - 0.004 17.6 5.6 0.23 12.0 0.7 2.1 2 0 0 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 ORX74081.1 - 0.0042 17.4 2.5 1.1 9.6 0.3 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) FYDLN_acid PF09538.10 ORX74081.1 - 0.0075 16.9 0.9 0.041 14.6 0.9 1.8 1 1 0 1 1 1 1 Protein of unknown function (FYDLN_acid) zf-ribbon_3 PF13248.6 ORX74081.1 - 0.0086 15.4 2.3 0.15 11.5 0.2 2.3 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ORX74081.1 - 0.012 16.4 0.4 0.014 16.2 0.4 1.1 1 0 0 1 1 1 0 zinc-ribbon family DZR PF12773.7 ORX74081.1 - 0.012 15.6 2.6 0.018 15.1 2.6 1.5 1 1 0 1 1 1 0 Double zinc ribbon zf-ISL3 PF14690.6 ORX74081.1 - 0.012 16.3 4.0 0.18 12.5 0.5 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 ADK_lid PF05191.14 ORX74081.1 - 0.013 15.5 0.6 0.15 12.1 0.7 2.1 1 1 1 2 2 2 0 Adenylate kinase, active site lid HypA PF01155.19 ORX74081.1 - 0.014 15.4 0.5 0.014 15.4 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 ORX74081.1 - 0.018 15.1 2.7 0.99 9.5 2.7 2.0 1 1 0 1 1 1 0 CpXC protein zinc_ribbon_4 PF13717.6 ORX74081.1 - 0.02 14.8 4.8 0.41 10.6 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_5 PF13909.6 ORX74081.1 - 0.021 14.5 4.3 0.021 14.5 4.3 2.9 2 2 0 2 2 2 0 C2H2-type zinc-finger domain zf_C2H2_10 PF18414.1 ORX74081.1 - 0.022 14.3 3.2 0.16 11.6 0.0 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger GAGA PF09237.11 ORX74081.1 - 0.026 14.3 0.9 2.5 8.0 0.3 2.1 1 1 1 2 2 2 0 GAGA factor zf-LYAR PF08790.11 ORX74081.1 - 0.028 14.3 2.4 3 7.8 0.7 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-LITAF-like PF10601.9 ORX74081.1 - 0.046 14.0 1.4 1.2 9.5 0.1 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-met PF12874.7 ORX74081.1 - 0.074 13.5 3.0 0.47 10.9 0.7 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type TF_Zn_Ribbon PF08271.12 ORX74081.1 - 0.083 12.4 1.6 4.5 6.9 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding DUF983 PF06170.12 ORX74081.1 - 0.092 13.2 1.5 2.4 8.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) zf-AN1 PF01428.16 ORX74081.1 - 0.14 12.3 8.0 1.8 8.8 1.7 2.3 1 1 1 2 2 2 0 AN1-like Zinc finger zinc_ribbon_9 PF14369.6 ORX74081.1 - 0.23 11.8 4.1 1 9.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon IBR PF01485.21 ORX74081.1 - 0.24 11.7 5.4 0.44 10.8 5.4 1.6 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain C1_4 PF07975.12 ORX74081.1 - 0.32 11.3 4.0 3.4 8.0 2.7 2.0 1 1 0 1 1 1 0 TFIIH C1-like domain DUF4764 PF15961.5 ORX74081.1 - 0.44 9.2 4.0 0.67 8.6 3.2 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4764) zf-C2H2_3 PF13878.6 ORX74081.1 - 0.48 10.3 5.7 8.3 6.3 1.1 2.5 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO Zn_Tnp_IS1595 PF12760.7 ORX74081.1 - 1 9.4 8.3 1.3 9.0 1.7 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain NADH-G_4Fe-4S_3 PF10588.9 ORX74081.1 - 1.1 8.8 6.3 5.1 6.7 0.2 2.4 3 0 0 3 3 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Zn_ribbon_SprT PF17283.2 ORX74081.1 - 1.5 8.8 8.5 0.75 9.8 5.3 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-ACC PF17848.1 ORX74081.1 - 3.1 7.9 9.8 9.3 6.4 1.2 2.9 2 2 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Tudor-knot PF11717.8 ORX74084.1 - 1.9e-06 27.7 0.1 4.6e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PWWP PF00855.17 ORX74084.1 - 0.0047 17.3 0.0 0.016 15.6 0.0 2.0 1 0 0 1 1 1 1 PWWP domain SET PF00856.28 ORX74084.1 - 0.1 13.0 0.0 0.49 10.8 0.0 2.0 2 0 0 2 2 2 0 SET domain Agenet PF05641.12 ORX74084.1 - 0.13 12.8 0.0 1 9.9 0.0 2.4 2 0 0 2 2 2 0 Agenet domain CKS PF01111.19 ORX74085.1 - 1.3e-32 111.9 1.0 1.6e-32 111.6 1.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Fungal_trans PF04082.18 ORX74086.1 - 1.5e-09 37.3 0.1 1e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain TPR_1 PF00515.28 ORX74087.1 - 1.3e-22 78.6 24.9 0.00017 21.2 0.1 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat ANAPC8 PF04049.13 ORX74087.1 - 5.5e-21 75.1 8.2 7.9e-19 68.1 5.2 3.2 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 ORX74087.1 - 2.5e-20 70.9 31.2 0.0035 17.3 0.2 8.6 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ORX74087.1 - 5.7e-19 66.7 21.2 0.00071 19.6 0.0 8.7 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX74087.1 - 3.9e-11 42.8 30.1 0.014 16.2 0.5 8.6 4 1 5 9 9 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 ORX74087.1 - 1e-09 38.5 28.7 0.0003 21.0 2.9 6.4 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX74087.1 - 1.2e-09 38.6 23.3 0.0054 17.2 0.4 7.2 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX74087.1 - 7.8e-08 31.8 29.9 0.0065 16.4 0.1 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX74087.1 - 6.6e-07 29.3 16.0 0.014 15.7 0.2 5.8 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX74087.1 - 5.9e-05 22.7 21.0 0.00018 21.1 0.0 6.0 5 2 2 7 7 7 2 TPR repeat TPR_9 PF13371.6 ORX74087.1 - 6.9e-05 22.9 18.2 0.041 14.0 0.7 4.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX74087.1 - 9.1e-05 21.8 13.6 0.015 14.6 2.1 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX74087.1 - 0.00054 20.1 24.8 1 9.6 0.0 6.2 5 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ORX74087.1 - 0.00072 19.3 23.4 1.2 9.1 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX74087.1 - 0.0015 19.2 28.1 0.06 14.0 0.2 6.3 5 2 1 6 6 6 2 Tetratricopeptide repeat PPR PF01535.20 ORX74087.1 - 0.13 12.5 0.6 15 6.1 0.0 3.9 4 0 0 4 4 3 0 PPR repeat TPR_6 PF13174.6 ORX74087.1 - 0.49 11.1 30.6 14 6.6 0.7 8.4 8 0 0 8 8 8 0 Tetratricopeptide repeat BTAD PF03704.17 ORX74087.1 - 0.91 9.9 9.3 0.7 10.3 4.5 3.0 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF2225 PF09986.9 ORX74087.1 - 1.3 8.7 5.7 0.2 11.4 0.5 2.4 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) GTP_EFTU PF00009.27 ORX74088.1 - 1.1e-20 74.0 0.0 2e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX74088.1 - 0.0006 19.9 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ORX74088.1 - 0.031 14.7 0.3 0.18 12.2 0.1 2.5 3 0 0 3 3 3 0 Elongation factor Tu domain 2 Sel1 PF08238.12 ORX74089.1 - 1.3e-05 25.7 0.0 0.086 13.6 0.0 2.6 2 0 0 2 2 2 2 Sel1 repeat Peptidase_A22B PF04258.13 ORX74090.1 - 1.3e-62 211.9 8.0 3.6e-62 210.5 8.0 1.6 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 ORX74090.1 - 2.1e-06 27.4 11.2 7e-05 22.4 11.2 2.5 1 1 1 2 2 2 2 Signal-peptide peptidase, presenilin aspartyl protease KCT2 PF17818.1 ORX74090.1 - 7.6 6.6 6.1 0.6 10.2 1.5 1.4 2 0 0 2 2 2 0 Keratinocyte-associated gene product Trypsin PF00089.26 ORX74092.1 - 1.5e-27 96.9 1.4 1.8e-27 96.6 1.4 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX74092.1 - 0.00031 21.7 0.1 0.00045 21.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Leader_Thr PF08254.11 ORX74092.1 - 0.084 12.6 0.3 0.084 12.6 0.3 2.4 2 0 0 2 2 2 0 Threonine leader peptide DUF1729 PF08354.10 ORX74095.1 - 3.4e-135 450.5 0.0 5.5e-135 449.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX74095.1 - 7.7e-54 183.3 0.5 1.4e-51 175.9 0.1 3.1 3 0 0 3 3 3 1 Acyl transferase domain Fas_alpha_ACP PF18325.1 ORX74095.1 - 1.6e-42 145.6 0.0 3.2e-42 144.6 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX74095.1 - 2.1e-35 122.2 0.0 5.1e-35 121.0 0.0 1.7 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX74095.1 - 3.9e-24 84.6 0.0 1.1e-23 83.1 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX74095.1 - 6.7e-21 74.6 0.0 1.3e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain Ketoacyl-synt_C PF02801.22 ORX74095.1 - 1e-12 48.1 0.0 2.6e-12 46.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SAT PF16073.5 ORX74095.1 - 4e-09 36.6 0.4 3.4e-06 27.0 0.0 3.0 3 0 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 ORX74095.1 - 1.6e-06 28.3 0.0 0.0004 20.5 0.0 2.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase ketoacyl-synt PF00109.26 ORX74095.1 - 0.00097 18.8 0.4 0.002 17.8 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ORX74096.1 - 5.1e-11 42.8 0.0 1.1e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 ORX74096.1 - 0.00068 19.6 0.0 0.0022 18.0 0.0 1.9 1 1 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta DUF1729 PF08354.10 ORX74097.1 - 4.1e-58 197.0 0.1 4.9e-58 196.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX74098.1 - 2.5e-48 165.3 0.1 3.8e-48 164.6 0.1 1.2 1 0 0 1 1 1 1 Acyl transferase domain MaoC_dehydratas PF01575.19 ORX74098.1 - 4.1e-17 61.9 0.5 1.2e-16 60.4 0.1 1.9 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ORX74098.1 - 0.0013 18.8 0.0 0.0045 17.1 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Fas_alpha_ACP PF18325.1 ORX74099.1 - 1.3e-46 158.9 0.0 2.3e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX74099.1 - 1.6e-31 109.5 0.2 1.1e-30 106.8 0.0 2.2 1 1 1 2 2 2 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ORX74099.1 - 5.8e-18 65.4 0.5 1.3e-17 64.2 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 ORX74099.1 - 0.025 14.0 0.1 0.047 13.0 0.1 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Hydrolase_4 PF12146.8 ORX74101.1 - 0.00037 19.8 0.1 0.00053 19.3 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74101.1 - 0.011 15.3 0.1 0.044 13.4 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX74101.1 - 0.065 12.7 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family SWI-SNF_Ssr4 PF08549.10 ORX74102.1 - 2.2e-07 30.0 0.5 2.7e-07 29.7 0.5 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) HEAT_2 PF13646.6 ORX74103.1 - 6.3e-06 26.5 10.0 0.055 13.9 2.0 4.6 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ORX74103.1 - 1.3e-05 25.0 18.2 0.34 11.3 0.0 8.0 9 0 0 9 9 9 3 HEAT repeat Cnd1 PF12717.7 ORX74103.1 - 0.0022 18.0 0.5 0.84 9.7 0.0 3.4 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ORX74103.1 - 0.0028 17.8 0.7 0.084 13.1 0.0 2.6 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ORX74103.1 - 0.0034 17.9 4.7 0.25 11.9 0.0 4.6 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region DASH_Ask1 PF08655.10 ORX74104.1 - 1.8e-16 59.8 0.2 4.3e-16 58.5 0.2 1.7 1 0 0 1 1 1 1 DASH complex subunit Ask1 UBA2_C PF16195.5 ORX74104.1 - 0.014 16.1 1.5 0.014 16.1 1.5 3.0 3 0 0 3 3 3 0 SUMO-activating enzyme subunit 2 C-terminus NOA36 PF06524.12 ORX74104.1 - 5.2 6.3 6.6 8.1 5.7 2.0 2.3 2 0 0 2 2 2 0 NOA36 protein ArfGap PF01412.18 ORX74105.1 - 3.7e-34 117.3 0.0 9.9e-34 115.9 0.0 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 ORX74105.1 - 1.6e-33 116.4 1.4 2.1e-33 116.0 1.4 1.1 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 ORX74105.1 - 7.5e-12 45.7 0.0 1.4e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.7 ORX74105.1 - 4.8e-11 43.1 0.1 1.5e-10 41.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX74105.1 - 9.7e-10 38.8 0.1 0.00056 20.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX74105.1 - 1.4e-08 34.8 0.5 0.00025 21.3 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) BAR PF03114.18 ORX74105.1 - 8.3e-06 25.6 1.0 1.3e-05 25.0 1.0 1.2 1 0 0 1 1 1 1 BAR domain Ank PF00023.30 ORX74105.1 - 1.6e-05 25.1 1.4 0.31 11.6 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ORX74105.1 - 0.00022 21.4 0.6 0.22 12.2 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Vps5 PF09325.10 ORX74105.1 - 0.64 9.5 3.7 1.1 8.7 3.7 1.3 1 0 0 1 1 1 0 Vps5 C terminal like Podoplanin PF05808.11 ORX74106.1 - 1.8e-05 24.9 0.6 2.9e-05 24.2 0.6 1.2 1 0 0 1 1 1 1 Podoplanin Plasmodium_Vir PF05795.11 ORX74106.1 - 0.004 16.6 0.0 0.0059 16.1 0.0 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Phage_holin_2_4 PF16082.5 ORX74106.1 - 0.08 12.7 0.1 0.22 11.3 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like ILVD_EDD PF00920.21 ORX74107.1 - 5e-202 672.1 3.4 5.9e-202 671.9 3.4 1.0 1 0 0 1 1 1 1 Dehydratase family FeoA PF04023.14 ORX74107.1 - 0.005 17.1 0.0 2.4 8.5 0.0 3.2 3 0 0 3 3 3 2 FeoA domain GTP_EFTU_D2 PF03144.25 ORX74107.1 - 0.039 14.3 0.2 16 6.0 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu domain 2 Sipho_tail PF05709.11 ORX74107.1 - 0.15 11.5 0.0 0.33 10.3 0.0 1.3 1 1 0 1 1 1 0 Phage tail protein DUF218 PF02698.17 ORX74108.1 - 2.2e-06 27.7 0.0 2.6e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain LMWPc PF01451.21 ORX74109.1 - 2.3e-47 160.9 0.0 2.6e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Cons_hypoth698 PF03601.14 ORX74110.1 - 0.057 12.3 0.5 0.094 11.6 0.5 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 698 DUF1516 PF07457.11 ORX74111.1 - 0.057 13.6 3.8 0.14 12.4 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) DUF4051 PF13260.6 ORX74111.1 - 0.15 11.8 0.0 0.15 11.8 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4051) Oxidored_q3 PF00499.20 ORX74111.1 - 0.19 11.4 5.5 0.46 10.2 2.5 2.4 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Cons_hypoth698 PF03601.14 ORX74111.1 - 0.43 9.4 3.9 0.19 10.6 0.5 1.9 1 1 1 2 2 2 0 Conserved hypothetical protein 698 VIT1 PF01988.19 ORX74111.1 - 0.79 9.6 8.1 4.4 7.1 0.4 2.7 2 1 1 3 3 3 0 VIT family Wzy_C PF04932.15 ORX74111.1 - 8.8 5.9 7.9 26 4.4 6.3 2.3 1 1 0 1 1 1 0 O-Antigen ligase MBOAT PF03062.19 ORX74112.1 - 3e-38 132.1 6.2 5.2e-38 131.3 6.2 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family TFIIB PF00382.19 ORX74113.1 - 3.4e-17 62.3 0.1 3.5e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Guanylin PF02058.15 ORX74113.1 - 0.0008 19.8 0.1 0.31 11.5 0.0 2.7 1 1 0 2 2 2 2 Guanylin precursor HRG PF16954.5 ORX74113.1 - 0.0071 16.7 0.1 0.015 15.7 0.1 1.5 1 0 0 1 1 1 1 Haem-transporter, endosomal/lysosomal, haem-responsive gene CAP PF00188.26 ORX74114.1 - 2e-11 44.8 1.1 7.9e-11 42.9 0.1 2.0 2 0 0 2 2 2 1 Cysteine-rich secretory protein family DUF3437 PF11919.8 ORX74114.1 - 0.19 11.7 0.5 0.37 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Sde2_N_Ubi PF13019.6 ORX74114.1 - 0.44 10.4 2.4 2.9 7.7 0.1 2.0 2 0 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain CAP PF00188.26 ORX74115.1 - 3.9e-13 50.3 0.6 3.9e-13 50.3 0.6 1.7 2 0 0 2 2 2 1 Cysteine-rich secretory protein family CASP_C PF08172.12 ORX74115.1 - 0.0034 16.8 0.0 0.004 16.5 0.0 1.1 1 0 0 1 1 1 1 CASP C terminal CAP PF00188.26 ORX74116.1 - 1.6e-11 45.1 0.1 2.6e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CASP_C PF08172.12 ORX74116.1 - 1.5e-05 24.5 0.0 1.8e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 CASP C terminal UBA_e1_thiolCys PF10585.9 ORX74116.1 - 0.047 13.6 0.1 0.059 13.3 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site Lipase_3 PF01764.25 ORX74117.1 - 8.9e-22 77.5 0.1 4.5e-21 75.2 0.1 1.9 1 1 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 ORX74117.1 - 0.0018 17.8 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 ORX74117.1 - 0.0018 18.0 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX74117.1 - 0.018 15.7 0.2 0.019 15.5 0.2 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX74117.1 - 0.084 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF915 PF06028.11 ORX74117.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 ORX74117.1 - 0.13 12.0 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein DUF2974 PF11187.8 ORX74117.1 - 0.19 11.2 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 ORX74118.1 - 5.9e-38 129.9 0.0 1.1e-37 129.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX74118.1 - 0.00022 20.9 0.1 0.00064 19.3 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX74118.1 - 0.0026 18.4 1.2 0.0042 17.7 0.5 1.5 1 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 ORX74118.1 - 0.031 14.0 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family LCCL PF03815.19 ORX74118.1 - 0.08 13.1 2.0 1.8 8.7 0.3 2.6 1 1 1 2 2 2 0 LCCL domain Peptidase_C12 PF01088.21 ORX74119.1 - 8.6e-61 205.3 0.0 5.5e-59 199.5 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 ORX74119.1 - 2e-13 50.0 0.0 4.4e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases CENP-F_leu_zip PF10473.9 ORX74119.1 - 0.00034 20.6 1.9 0.00038 20.5 0.7 1.6 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 ORX74119.1 - 0.035 14.2 1.7 0.06 13.4 1.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding PRP21_like_P PF12230.8 ORX74120.1 - 5e-42 144.2 14.2 1e-41 143.2 14.2 1.5 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 ORX74120.1 - 1.4e-34 117.8 4.4 9.2e-17 60.8 0.6 2.5 2 0 0 2 2 2 2 Surp module RNA_pol_Rpc4 PF05132.14 ORX74120.1 - 0.012 16.1 0.7 0.028 14.9 0.7 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4746 PF15928.5 ORX74120.1 - 0.098 12.1 11.7 0.17 11.2 10.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) SAPS PF04499.15 ORX74120.1 - 3 6.5 8.3 4.8 5.9 8.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ras PF00071.22 ORX74121.1 - 2.5e-42 144.2 0.2 1.6e-41 141.6 0.2 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ORX74121.1 - 6.9e-21 74.7 0.1 1.6e-19 70.3 0.1 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX74121.1 - 9.4e-08 31.7 0.0 1.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.27 ORX74121.1 - 0.0014 19.1 0.0 0.0021 18.6 0.0 1.4 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 ORX74121.1 - 0.0046 17.0 0.0 0.016 15.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX74121.1 - 0.012 16.0 0.1 0.017 15.5 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 ORX74121.1 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 ORX74121.1 - 0.025 14.5 0.1 1.1 9.1 0.0 2.4 1 1 2 3 3 3 0 RsgA GTPase Dynamin_N PF00350.23 ORX74121.1 - 0.046 13.8 0.0 0.055 13.5 0.0 1.3 1 1 0 1 1 1 0 Dynamin family AAA PF00004.29 ORX74121.1 - 0.049 14.0 0.0 0.092 13.2 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX74121.1 - 0.053 13.8 0.1 0.27 11.5 0.0 2.0 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.10 ORX74121.1 - 0.069 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ORX74121.1 - 0.081 12.4 0.1 3.4 7.2 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 ORX74121.1 - 0.11 12.7 0.1 0.42 10.8 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX74121.1 - 0.11 12.2 0.1 0.16 11.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX74121.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.9 ORX74121.1 - 0.13 12.0 0.1 0.37 10.5 0.0 1.7 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 ORX74121.1 - 0.14 12.1 0.0 0.36 10.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 ORX74121.1 - 0.18 11.2 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein UPF0139 PF03669.13 ORX74122.1 - 2.6e-07 30.4 0.0 3.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF5400 PF17379.2 ORX74122.1 - 0.026 15.0 0.1 0.031 14.7 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5400) GTP_cyclohydroI PF01227.22 ORX74123.1 - 1.9e-74 249.0 0.0 2.5e-74 248.6 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ORX74123.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein NST1 PF13945.6 ORX74123.1 - 0.22 11.6 0.0 0.33 11.0 0.0 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Fungal_trans PF04082.18 ORX74124.1 - 0.0027 16.8 0.0 0.0033 16.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cas_Csx8 PF09657.10 ORX74124.1 - 0.26 10.2 0.0 0.32 9.9 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) Zn_clus PF00172.18 ORX74126.1 - 4.8e-06 26.6 11.4 9.2e-06 25.7 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX74126.1 - 0.0015 17.6 0.0 0.0027 16.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Med9 PF07544.13 ORX74126.1 - 0.18 11.9 0.5 1.2 9.3 0.7 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PrmC_N PF17827.1 ORX74127.1 - 8.9e-06 26.2 0.7 6.9e-05 23.4 0.7 2.3 1 1 0 1 1 1 1 PrmC N-terminal domain Glyco_transf_25 PF01755.17 ORX74128.1 - 0.0011 18.8 0.0 0.099 12.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Rif1_N PF12231.8 ORX74130.1 - 1.7e-18 66.8 0.8 6e-18 65.0 0.7 1.7 1 1 1 2 2 2 2 Rap1-interacting factor 1 N terminal IFRD PF05004.13 ORX74130.1 - 0.0015 17.7 0.5 0.51 9.4 0.0 2.1 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) UME PF08064.13 ORX74130.1 - 0.0055 16.6 1.1 0.02 14.8 0.3 2.3 1 1 1 2 2 2 1 UME (NUC010) domain HEAT PF02985.22 ORX74130.1 - 0.016 15.4 3.7 5 7.7 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat Vps5 PF09325.10 ORX74133.1 - 1.1e-10 41.5 3.9 1.5e-10 41.1 3.9 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ORX74133.1 - 0.00014 21.8 0.0 0.00036 20.5 0.0 1.7 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.9 ORX74133.1 - 0.0002 20.9 1.6 0.001 18.6 1.6 2.0 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein Cyclin PF08613.11 ORX74134.1 - 1.3e-33 116.6 0.0 1.6e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX74134.1 - 0.00025 20.8 0.0 0.00034 20.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain MFS_1 PF07690.16 ORX74135.1 - 1.6e-42 145.7 39.0 1.6e-42 145.7 39.0 3.5 2 2 1 3 3 3 1 Major Facilitator Superfamily YhhN PF07947.14 ORX74135.1 - 3.2e-28 98.6 18.2 3.2e-28 98.6 18.2 2.9 2 0 0 2 2 2 1 YhhN family OATP PF03137.20 ORX74135.1 - 0.28 9.4 13.2 4 5.6 13.2 2.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DLH PF01738.18 ORX74136.1 - 1.3e-14 54.3 0.1 2.6e-14 53.3 0.1 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family MFS_1 PF07690.16 ORX74137.1 - 6.4e-51 173.3 48.9 2e-50 171.7 46.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX74137.1 - 3.8e-16 58.7 24.5 8e-16 57.6 24.2 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX74137.1 - 1.2e-12 47.5 13.7 1.2e-12 47.5 13.7 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter Deltameth_res PF16020.5 ORX74137.1 - 5.8 6.9 6.0 22 5.0 0.0 3.9 3 0 0 3 3 3 0 Deltamethrin resistance AC_N PF16214.5 ORX74139.1 - 0.41 9.7 2.3 0.71 8.9 0.7 2.1 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region HLH PF00010.26 ORX74140.1 - 3.9e-15 55.5 0.0 7.8e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SUIM_assoc PF16619.5 ORX74140.1 - 0.79 9.8 7.7 2.5 8.2 2.2 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 FHA PF00498.26 ORX74141.1 - 7.3e-17 61.5 0.0 1.4e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX74141.1 - 0.0001 22.5 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DnaJ PF00226.31 ORX74142.1 - 2.4e-26 91.6 1.3 2.8e-26 91.4 1.3 1.1 1 0 0 1 1 1 1 DnaJ domain Serglycin PF04360.12 ORX74142.1 - 0.023 14.6 0.0 0.025 14.5 0.0 1.1 1 0 0 1 1 1 0 Serglycin RPT PF13446.6 ORX74142.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 A repeated domain in UCH-protein MFS_1 PF07690.16 ORX74144.1 - 2.1e-36 125.6 22.3 3.7e-36 124.8 22.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX74144.1 - 2.1e-12 46.7 13.2 2.1e-12 46.7 13.2 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 ORX74144.1 - 0.00021 20.7 3.9 0.00021 20.7 3.9 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ORX74144.1 - 0.034 12.4 9.9 0.0066 14.8 2.5 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Clostridium_P47 PF06597.11 ORX74144.1 - 0.14 10.9 1.5 0.21 10.3 1.5 1.2 1 0 0 1 1 1 0 Clostridium P-47 protein MFS_1 PF07690.16 ORX74145.1 - 1.1e-44 152.9 37.9 1.4e-44 152.5 37.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX74145.1 - 2.6e-09 36.1 10.8 2.6e-09 36.1 10.8 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX74145.1 - 1.2e-07 31.0 26.2 6.3e-07 28.6 11.3 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 ORX74145.1 - 0.15 10.3 14.0 5.2 5.2 13.9 2.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DLH PF01738.18 ORX74146.1 - 3.4e-09 36.6 0.0 4.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DLH PF01738.18 ORX74147.1 - 5.3e-05 22.9 0.0 5.5e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family LSM PF01423.22 ORX74148.1 - 7e-20 70.5 0.0 7.8e-20 70.3 0.0 1.0 1 0 0 1 1 1 1 LSM domain VirC2 PF07181.11 ORX74148.1 - 0.16 11.5 0.0 0.16 11.4 0.0 1.0 1 0 0 1 1 1 0 VirC2 protein AAA_18 PF13238.6 ORX74149.1 - 6.3e-10 39.7 0.0 8.6e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 ORX74149.1 - 5.9e-08 33.0 0.2 6.3e-06 26.4 0.2 2.3 1 1 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 ORX74149.1 - 1.6e-06 28.4 0.0 6.2e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX74149.1 - 0.0044 17.4 0.1 0.0068 16.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 ORX74149.1 - 0.0067 16.3 0.0 1.9 8.3 0.0 2.3 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_17 PF13207.6 ORX74149.1 - 0.0093 16.4 1.2 0.11 12.9 1.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX74149.1 - 0.012 15.9 0.0 0.037 14.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ORX74149.1 - 0.012 15.3 0.1 0.022 14.5 0.1 1.6 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 ORX74149.1 - 0.017 15.7 0.0 0.021 15.4 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA PF00004.29 ORX74149.1 - 0.017 15.5 0.0 0.027 14.9 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 ORX74149.1 - 0.018 15.2 0.3 0.15 12.2 0.0 2.1 1 1 0 2 2 2 0 Cytidylate kinase-like family Cytidylate_kin PF02224.18 ORX74149.1 - 0.03 14.0 0.0 0.097 12.4 0.0 1.9 1 1 1 2 2 2 0 Cytidylate kinase AAA_28 PF13521.6 ORX74149.1 - 0.059 13.6 0.2 0.11 12.8 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX74149.1 - 0.059 12.9 0.6 1.9 8.1 0.1 2.4 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX74149.1 - 0.08 12.2 0.0 0.17 11.1 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 ORX74149.1 - 0.092 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX74149.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 ORX74149.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase CoaE PF01121.20 ORX74149.1 - 0.15 11.7 0.1 0.45 10.2 0.0 1.8 2 0 0 2 2 2 0 Dephospho-CoA kinase Trypsin_2 PF13365.6 ORX74150.1 - 2.5e-18 67.4 0.1 1.8e-16 61.4 0.0 2.5 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 ORX74150.1 - 2.5e-16 59.3 0.3 3.8e-07 29.8 0.2 4.0 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 ORX74150.1 - 1.8e-14 53.8 0.0 1.8e-05 25.0 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 ORX74150.1 - 3.2e-11 43.4 0.0 2.3e-05 24.6 0.0 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_1 PF12812.7 ORX74150.1 - 3e-05 23.9 0.1 0.00032 20.6 0.0 2.7 4 0 0 4 4 4 1 PDZ-like domain Cuticle_3 PF11018.8 ORX74150.1 - 0.1 12.8 0.2 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Pupal cuticle protein C1 Tricorn_PDZ PF14685.6 ORX74150.1 - 0.14 12.1 0.0 5.9 6.9 0.0 2.9 3 0 0 3 3 3 0 Tricorn protease PDZ domain PHP PF02811.19 ORX74151.1 - 1.4e-05 25.5 0.0 2.6e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 PHP domain RESP18 PF14948.6 ORX74151.1 - 0.029 14.7 0.0 0.064 13.6 0.0 1.6 1 0 0 1 1 1 0 RESP18 domain Vps54 PF07928.12 ORX74152.1 - 1.4e-47 161.5 0.1 3.4e-47 160.3 0.1 1.7 1 0 0 1 1 1 1 Vps54-like protein DUF2451 PF10474.9 ORX74152.1 - 0.028 14.2 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) MAGE PF01454.19 ORX74153.1 - 1.7e-19 70.4 0.0 1.2e-08 34.9 0.0 2.1 1 1 1 2 2 2 2 MAGE family WD40 PF00400.32 ORX74154.1 - 0.0017 19.2 1.8 3.5 8.7 0.1 4.6 3 1 0 3 3 3 1 WD domain, G-beta repeat Ribosomal_L4 PF00573.22 ORX74155.1 - 2.6e-48 164.3 0.1 4.7e-48 163.4 0.1 1.4 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family Transferase PF02458.15 ORX74156.1 - 0.1 11.2 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Transferase family Transferase PF02458.15 ORX74157.1 - 3.9e-12 45.6 0.0 2.5e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Transferase family Indigoidine_A PF04227.12 ORX74159.1 - 1.9e-133 444.3 4.8 2.2e-133 444.1 4.8 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein LPD22 PF18834.1 ORX74159.1 - 0.031 14.5 0.1 1.6 9.0 0.1 2.5 2 0 0 2 2 2 0 Large polyvalent protein associated domain 22 UDG PF03167.19 ORX74160.1 - 2.9e-14 53.3 0.0 4.2e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily GTP_EFTU_D3 PF03143.17 ORX74161.1 - 3.8e-43 146.3 0.0 7.3e-43 145.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX74161.1 - 4e-14 52.7 2.3 4e-14 52.7 2.3 2.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 Semialdhyde_dhC PF02774.18 ORX74161.1 - 0.0061 16.6 0.8 0.062 13.4 0.1 2.4 2 1 1 3 3 3 1 Semialdehyde dehydrogenase, dimerisation domain NIF3 PF01784.18 ORX74161.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) HSP70 PF00012.20 ORX74162.1 - 1.2e-57 195.5 34.4 4.7e-56 190.2 8.0 5.0 2 2 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 ORX74162.1 - 2.6e-05 23.2 1.4 7e-05 21.8 1.4 1.6 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 ORX74162.1 - 0.00018 21.3 0.1 0.00069 19.4 0.1 2.0 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Peptidase_M22 PF00814.25 ORX74162.1 - 0.0053 16.5 0.1 0.6 9.8 0.0 2.6 2 0 0 2 2 2 2 Glycoprotease family LMBR1 PF04791.16 ORX74164.1 - 1.6e-118 396.9 9.5 1.8e-118 396.7 9.5 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Ribosomal_L13e PF01294.18 ORX74165.1 - 7.1e-70 234.5 9.0 8.6e-70 234.2 9.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4473 PF14747.6 ORX74165.1 - 0.017 15.6 0.7 0.045 14.3 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) SH3_9 PF14604.6 ORX74166.1 - 0.13 12.2 0.2 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain Ribosomal_S9 PF00380.19 ORX74167.1 - 8.9e-32 110.2 0.1 1e-31 110.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L32e PF01655.18 ORX74168.1 - 1.5e-34 118.7 0.5 1.1e-33 115.9 0.5 1.9 1 1 0 1 1 1 1 Ribosomal protein L32 AAA PF00004.29 ORX74170.1 - 1.2e-43 148.7 0.0 3.3e-43 147.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX74170.1 - 1.7e-12 46.9 0.1 4.2e-12 45.7 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ORX74170.1 - 6.2e-08 32.5 1.1 1.6e-07 31.2 1.1 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 ORX74170.1 - 1e-07 32.2 0.0 3.3e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ORX74170.1 - 1.9e-06 27.9 0.0 1e-05 25.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX74170.1 - 3.1e-06 27.7 0.0 6.5e-05 23.4 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX74170.1 - 1.3e-05 25.5 1.3 0.0057 16.9 0.1 3.2 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ORX74170.1 - 8.5e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ORX74170.1 - 0.00077 20.0 0.1 0.022 15.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 ORX74170.1 - 0.0011 18.3 0.0 0.003 16.8 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ORX74170.1 - 0.0013 18.9 0.0 0.0035 17.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ORX74170.1 - 0.0022 17.9 0.1 0.017 15.0 0.0 2.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ORX74170.1 - 0.0024 17.6 0.0 0.0052 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase PF06745.13 ORX74170.1 - 0.0045 16.4 0.1 0.024 14.0 0.0 2.1 2 0 0 2 2 2 1 KaiC AAA_13 PF13166.6 ORX74170.1 - 0.006 15.3 2.4 0.33 9.5 2.8 2.1 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ORX74170.1 - 0.0078 15.7 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 ORX74170.1 - 0.0084 15.5 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DivIC PF04977.15 ORX74170.1 - 0.0088 15.8 4.9 0.021 14.6 4.9 1.6 1 0 0 1 1 1 1 Septum formation initiator AAA_28 PF13521.6 ORX74170.1 - 0.0091 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ORX74170.1 - 0.012 14.8 0.1 0.04 13.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 ORX74170.1 - 0.019 15.0 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ORX74170.1 - 0.027 14.2 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 ORX74170.1 - 0.029 14.1 0.0 0.074 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX74170.1 - 0.033 14.2 0.0 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX74170.1 - 0.035 14.5 0.0 0.089 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ORX74170.1 - 0.042 13.4 0.0 0.074 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 ORX74170.1 - 0.044 13.6 0.7 0.42 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DASH_Dad2 PF08654.10 ORX74170.1 - 0.055 13.9 0.5 0.18 12.2 0.5 1.9 1 0 0 1 1 1 0 DASH complex subunit Dad2 Parvo_NS1 PF01057.17 ORX74170.1 - 0.058 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 ORX74170.1 - 0.063 13.6 0.1 0.53 10.6 0.0 2.4 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.6 ORX74170.1 - 0.076 12.6 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX74170.1 - 0.11 12.4 0.0 0.67 9.9 0.0 2.1 1 1 1 2 2 2 0 NACHT domain UNC-93 PF05978.16 ORX74171.1 - 1.5e-13 50.8 4.0 1.5e-13 50.8 4.0 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ORX74171.1 - 1.8e-11 43.6 25.4 3.3e-11 42.7 25.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily PrgI PF12666.7 ORX74171.1 - 0.67 10.7 0.0 0.67 10.7 0.0 3.3 3 1 0 3 3 3 0 PrgI family protein DUF1304 PF06993.12 ORX74171.1 - 9.9 6.2 18.0 1.5 8.9 4.5 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1304) DCP1 PF06058.13 ORX74173.1 - 1.9e-38 131.0 0.0 2.2e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Dcp1-like decapping family SH3_1 PF00018.28 ORX74174.1 - 9.4e-11 41.1 0.3 2.1e-10 40.1 0.3 1.6 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX74174.1 - 7.6e-10 38.5 0.0 1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX74174.1 - 5e-08 32.5 0.0 6.1e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 ORX74174.1 - 0.039 13.7 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) p450 PF00067.22 ORX74177.1 - 6.2e-19 68.1 0.2 6.9e-19 67.9 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aconitase PF00330.20 ORX74178.1 - 2.7e-75 254.2 1.1 2.3e-61 208.2 0.1 3.0 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX74178.1 - 1.7e-20 73.7 0.0 3.8e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Glucosamine_iso PF01182.20 ORX74179.1 - 5.6e-19 68.9 0.0 9.4e-19 68.2 0.0 1.3 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase OCC1 PF15506.6 ORX74179.1 - 0.2 11.8 0.1 1.4 9.1 0.0 2.2 2 0 0 2 2 2 0 OCC1 family Fungal_trans PF04082.18 ORX74183.1 - 5.1e-16 58.5 0.1 8.7e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX74183.1 - 9.8e-08 32.0 13.8 1.7e-07 31.2 13.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L13 PF00572.18 ORX74184.1 - 3.6e-11 43.4 0.0 2.9e-09 37.2 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 Arf PF00025.21 ORX74185.1 - 1.1e-65 220.4 0.0 1.2e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ORX74185.1 - 8.9e-11 41.5 0.1 2.5e-07 30.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX74185.1 - 2.6e-09 36.8 0.0 3.4e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX74185.1 - 2.5e-08 33.7 0.0 3.3e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX74185.1 - 4.7e-08 33.3 0.0 1.2e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX74185.1 - 8.7e-07 29.0 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX74185.1 - 7.6e-06 25.4 0.0 8.8e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 ORX74185.1 - 0.057 13.0 0.0 2.2 7.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ORX74185.1 - 0.12 12.1 0.0 0.48 10.2 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SKN1 PF03935.15 ORX74186.1 - 1e-106 357.4 5.2 7.3e-59 199.5 0.7 2.3 1 1 1 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) CBM_14 PF01607.24 ORX74187.1 - 0.00013 22.1 9.3 0.0012 18.9 0.3 3.6 2 1 1 3 3 3 2 Chitin binding Peritrophin-A domain NB PF04159.13 ORX74188.1 - 2.9 8.0 7.6 16 5.6 0.2 3.7 1 1 3 4 4 4 0 NB glycoprotein Peptidase_M24 PF00557.24 ORX74189.1 - 2.1e-50 171.3 0.0 3.4e-49 167.4 0.0 2.1 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.16 ORX74189.1 - 3.2e-34 117.3 0.0 6.9e-34 116.2 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Thioredoxin PF00085.20 ORX74190.1 - 4.5e-17 61.9 0.0 5.5e-17 61.6 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ORX74190.1 - 0.0061 16.0 0.0 0.0081 15.5 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ORX74190.1 - 0.014 15.8 0.0 0.019 15.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ORX74190.1 - 0.12 12.7 0.0 3.3 8.1 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like SET PF00856.28 ORX74191.1 - 6.1e-13 49.5 0.1 1.5e-11 44.9 0.1 2.2 1 1 0 1 1 1 1 SET domain zf-FLZ PF04570.14 ORX74191.1 - 0.032 13.7 1.3 0.22 11.0 0.5 2.5 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 Usp PF00582.26 ORX74192.1 - 1e-12 48.7 0.0 1.1e-12 48.6 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family E1-E2_ATPase PF00122.20 ORX74193.1 - 5.5e-42 143.3 2.3 5.5e-42 143.3 2.3 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX74193.1 - 2.5e-38 131.6 9.7 2.5e-38 131.6 9.7 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX74193.1 - 2.1e-19 70.7 0.5 3.7e-09 37.2 1.0 3.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX74193.1 - 5.3e-19 68.1 0.0 1.3e-18 66.8 0.0 1.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX74193.1 - 3.7e-10 39.4 0.0 8.8e-10 38.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX74193.1 - 4.3e-08 33.2 0.3 1.1e-07 31.8 0.3 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX74194.1 - 5.4e-41 140.1 2.9 5.4e-41 140.1 2.9 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX74194.1 - 3e-38 131.4 9.9 3e-38 131.4 9.9 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX74194.1 - 1.9e-19 70.8 0.3 3.4e-09 37.3 0.8 3.3 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX74194.1 - 5.3e-19 68.1 0.0 1.3e-18 66.8 0.0 1.7 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX74194.1 - 3.7e-10 39.3 0.0 8.8e-10 38.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX74194.1 - 6.8e-08 32.5 1.1 1.1e-07 31.8 0.3 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase LRR_6 PF13516.6 ORX74195.1 - 5.7e-05 22.8 2.3 0.05 13.7 0.0 4.5 5 0 0 5 5 5 2 Leucine Rich repeat F-box-like PF12937.7 ORX74195.1 - 0.0012 18.7 0.1 0.0047 16.8 0.2 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX74195.1 - 0.0061 16.4 0.1 0.021 14.7 0.1 2.0 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ORX74195.1 - 0.023 15.1 0.2 2.5 8.6 0.1 3.6 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF4112 PF13430.6 ORX74196.1 - 1.1e-14 54.6 0.0 1.2e-14 54.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) HAUS6_N PF14661.6 ORX74197.1 - 0.034 13.7 0.4 0.039 13.5 0.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus CREPT PF16566.5 ORX74197.1 - 0.2 11.8 6.1 0.18 12.0 4.5 1.6 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour WD40 PF00400.32 ORX74198.1 - 1.6e-23 82.5 11.5 0.00012 22.8 0.1 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74198.1 - 2.6e-09 37.2 4.8 0.028 14.7 0.1 4.1 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ORX74198.1 - 0.12 11.1 0.5 13 4.4 0.0 2.7 3 0 0 3 3 3 0 Nup133 N terminal like Usp PF00582.26 ORX74199.1 - 1.3e-14 54.9 0.1 1.8e-14 54.4 0.1 1.2 1 0 0 1 1 1 1 Universal stress protein family E1-E2_ATPase PF00122.20 ORX74200.1 - 4.3e-41 140.4 2.2 4.3e-41 140.4 2.2 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX74200.1 - 6e-35 120.6 5.8 6e-35 120.6 5.8 3.0 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX74200.1 - 1.9e-19 70.8 0.2 3e-09 37.5 0.6 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX74200.1 - 3.7e-19 68.6 0.0 1.4e-18 66.8 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX74200.1 - 4.3e-10 39.1 0.0 1.3e-09 37.6 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX74200.1 - 9.2e-08 32.1 0.2 2.4e-07 30.8 0.2 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Wzy_C_2 PF11846.8 ORX74200.1 - 0.12 12.3 1.4 9.6 6.1 0.6 2.4 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal RIX1 PF08167.12 ORX74201.1 - 0.041 13.6 1.1 0.044 13.5 0.1 1.5 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis 3-HAO PF06052.12 ORX74203.1 - 0.086 12.5 0.0 0.087 12.5 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Ribosomal_L27e PF01777.18 ORX74204.1 - 6e-35 119.5 4.8 1e-34 118.7 4.8 1.4 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 ORX74204.1 - 6.7e-05 22.7 1.0 0.00016 21.5 1.0 1.6 1 0 0 1 1 1 1 KOW motif RNase_T PF00929.24 ORX74205.1 - 1.3e-24 87.6 0.0 1.6e-24 87.3 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ORX74205.1 - 0.018 15.0 0.0 0.025 14.6 0.0 1.3 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like TusA PF01206.17 ORX74205.1 - 0.15 11.9 0.0 3.2 7.6 0.0 2.6 3 0 0 3 3 3 0 Sulfurtransferase TusA RNase_T PF00929.24 ORX74206.1 - 3.2e-36 125.4 0.0 3.6e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Exonuclease AMP-binding PF00501.28 ORX74207.1 - 1.5e-94 317.0 0.0 2e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX74207.1 - 6.2e-29 100.8 2.0 2.6e-27 95.6 0.8 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ORX74207.1 - 8.6e-21 73.6 0.1 2.2e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus DUF4266 PF14086.6 ORX74208.1 - 0.18 12.8 0.7 1.6 9.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) LSM PF01423.22 ORX74209.1 - 1.4e-16 59.9 0.4 1.9e-16 59.5 0.4 1.2 1 0 0 1 1 1 1 LSM domain Noc2 PF03715.13 ORX74210.1 - 1.4e-110 369.3 0.6 2.5e-110 368.4 0.6 1.4 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 ORX74210.1 - 8.7e-05 21.0 18.6 0.01 14.1 14.4 2.3 2 0 0 2 2 2 2 Nop14-like family SDA1 PF05285.12 ORX74210.1 - 0.37 10.2 18.3 0.61 9.5 18.3 1.3 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 ORX74210.1 - 2.1 6.8 16.8 9.3 4.7 16.3 2.0 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 ORX74210.1 - 6.1 6.9 19.3 0.91 9.6 15.4 1.6 2 0 0 2 2 2 0 YL1 nuclear protein CDC45 PF02724.14 ORX74210.1 - 8.9 4.5 14.1 13 3.9 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ORX74210.1 - 9.1 5.3 20.3 14 4.6 20.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sof1 PF04158.14 ORX74211.1 - 2.3e-28 98.3 9.2 4e-28 97.5 9.2 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 ORX74211.1 - 5.3e-23 80.9 4.9 9.9e-05 23.0 0.0 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74211.1 - 4.9e-06 26.7 0.2 0.019 15.2 0.0 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PTPS PF01242.19 ORX74212.1 - 1.5e-31 108.9 0.1 1.7e-31 108.8 0.1 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase Pex14_N PF04695.13 ORX74213.1 - 5.3e-26 92.1 11.3 2.6e-17 63.9 0.2 3.4 2 2 1 3 3 3 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Med8 PF10232.9 ORX74213.1 - 0.0075 15.9 0.4 0.0094 15.6 0.4 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 HAUS-augmin3 PF14932.6 ORX74213.1 - 0.033 13.8 3.0 0.055 13.0 3.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Nop25 PF09805.9 ORX74213.1 - 0.034 14.6 0.2 0.05 14.1 0.2 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) COX4 PF02936.14 ORX74213.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV ADIP PF11559.8 ORX74213.1 - 0.39 10.8 10.4 1 9.4 10.4 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding CiPC PF15800.5 ORX74213.1 - 1.6 8.4 6.0 0.97 9.1 3.5 1.8 2 0 0 2 2 2 0 Clock interacting protein circadian WD40 PF00400.32 ORX74214.1 - 8.4e-17 61.3 20.0 0.00064 20.5 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74214.1 - 1.4e-08 34.9 0.7 0.29 11.5 0.0 4.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX74214.1 - 4.2e-05 22.4 2.5 0.018 13.7 0.4 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ORX74214.1 - 0.00047 19.8 0.7 0.0024 17.5 0.7 2.2 1 1 0 1 1 1 1 PQQ-like domain DUF2415 PF10313.9 ORX74214.1 - 0.11 12.5 5.5 2.9 7.9 0.2 3.5 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) COG4 PF08318.12 ORX74215.1 - 1.4e-49 169.0 0.0 2.3e-49 168.3 0.0 1.3 1 1 0 1 1 1 1 COG4 transport protein TetR_C_31 PF17940.1 ORX74215.1 - 0.031 14.5 0.2 0.031 14.5 0.2 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain MCM PF00493.23 ORX74216.1 - 1.1e-86 289.6 0.1 1.8e-86 288.9 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX74216.1 - 1.3e-15 57.4 0.1 2.5e-14 53.2 0.1 2.4 1 1 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX74216.1 - 6.7e-10 39.3 0.0 1.5e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ORX74216.1 - 4.7e-07 29.4 0.0 8.7e-06 25.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX74216.1 - 1.2e-06 28.4 0.0 4.5e-06 26.5 0.0 2.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX74216.1 - 0.0041 17.1 0.0 0.01 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_6 PF12774.7 ORX74216.1 - 0.075 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region MCM_N PF14551.6 ORX74216.1 - 0.12 13.0 0.0 0.27 11.9 0.0 1.5 1 0 0 1 1 1 0 MCM N-terminal domain HMGL-like PF00682.19 ORX74217.1 - 5.1e-75 252.4 0.2 7e-75 252.0 0.2 1.2 1 0 0 1 1 1 1 HMGL-like Iso_dh PF00180.20 ORX74218.1 - 6.7e-73 245.8 1.8 1.1e-70 238.5 1.8 3.1 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GIDA PF01134.22 ORX74219.1 - 3e-140 467.8 0.0 3.8e-140 467.4 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 ORX74219.1 - 1.6e-47 162.5 0.0 3.1e-47 161.5 0.0 1.5 1 0 0 1 1 1 1 GidA associated domain UCH PF00443.29 ORX74221.1 - 0.00081 19.0 0.0 0.0012 18.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ATG16 PF08614.11 ORX74222.1 - 0.002 18.4 2.2 0.0021 18.3 2.2 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3138 PF11336.8 ORX74222.1 - 0.011 14.4 0.1 0.011 14.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) JAKMIP_CC3 PF16034.5 ORX74222.1 - 0.014 15.4 3.1 0.015 15.2 3.1 1.1 1 0 0 1 1 1 0 JAKMIP CC3 domain Cnn_1N PF07989.11 ORX74222.1 - 0.015 15.4 4.6 0.068 13.3 1.2 2.0 1 1 0 2 2 2 0 Centrosomin N-terminal motif 1 TMF_DNA_bd PF12329.8 ORX74222.1 - 0.068 13.2 1.5 0.068 13.2 1.5 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Chibby PF14645.6 ORX74222.1 - 0.1 13.0 1.2 0.16 12.4 1.2 1.5 1 1 0 1 1 1 0 Chibby family Glutaredoxin PF00462.24 ORX74223.1 - 2.3e-18 66.1 0.0 2.4e-17 62.9 0.0 2.1 2 0 0 2 2 2 1 Glutaredoxin PAC2 PF09754.9 ORX74223.1 - 0.12 12.4 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 PAC2 family DPPIV_N PF00930.21 ORX74224.1 - 7.3e-92 307.9 1.8 9e-92 307.5 1.8 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ORX74224.1 - 6e-53 179.5 4.0 5.5e-52 176.3 3.6 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ORX74224.1 - 0.0036 16.9 2.8 0.01 15.4 0.6 2.4 2 1 1 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 ORX74224.1 - 0.073 12.3 0.2 1.4 8.1 0.0 2.2 1 1 1 2 2 2 0 Serine aminopeptidase, S33 PKD PF00801.20 ORX74224.1 - 0.089 12.7 0.5 0.25 11.2 0.5 1.8 1 0 0 1 1 1 0 PKD domain Ribosomal_S21 PF01165.20 ORX74225.1 - 1.9e-12 46.7 3.8 3.1e-12 46.0 3.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 TrbI PF03743.14 ORX74225.1 - 0.04 13.7 0.1 0.052 13.4 0.1 1.1 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein Attacin_N PF03768.15 ORX74225.1 - 0.21 11.7 1.6 0.34 11.1 1.6 1.3 1 0 0 1 1 1 0 Attacin, N-terminal region TP6A_N PF04406.14 ORX74227.1 - 3.6e-11 42.9 0.2 5.7e-11 42.2 0.2 1.3 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Herpes_UL25 PF01499.16 ORX74227.1 - 0.27 9.7 0.0 0.36 9.3 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family WD40 PF00400.32 ORX74229.1 - 0.00011 22.9 16.6 0.00048 20.9 0.3 6.1 5 3 0 5 5 5 2 WD domain, G-beta repeat LRR_6 PF13516.6 ORX74230.1 - 2.8e-06 26.9 4.8 1.5 9.1 0.1 5.9 6 0 0 6 6 6 2 Leucine Rich repeat LRR_8 PF13855.6 ORX74230.1 - 0.13 12.0 4.3 17 5.3 0.1 3.9 3 1 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 ORX74230.1 - 0.42 11.1 5.5 7.5 7.1 0.1 4.0 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX74230.1 - 2 9.3 10.0 19 6.3 0.1 5.3 5 1 1 6 6 6 0 Leucine Rich Repeat Myb_DNA-binding PF00249.31 ORX74231.1 - 4.3e-13 49.2 0.6 1.1e-11 44.7 0.2 2.9 3 1 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX74231.1 - 3.3e-12 46.5 0.1 3.2e-11 43.3 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Rap1_C PF11626.8 ORX74231.1 - 1.4e-05 25.0 0.1 3.9e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.9 ORX74231.1 - 7.3e-05 23.0 2.1 0.13 12.6 0.0 2.6 1 1 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like SLIDE PF09111.10 ORX74231.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 SLIDE Peptidase_M3_N PF08439.10 ORX74231.1 - 0.015 15.5 0.1 9.3 6.6 0.0 2.6 2 0 0 2 2 2 0 Oligopeptidase F DUF1376 PF07120.11 ORX74231.1 - 0.025 14.9 0.1 0.078 13.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) DUF2108 PF09881.9 ORX74233.1 - 0.087 12.8 0.1 0.33 10.9 0.1 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2108) Abhydrolase_1 PF00561.20 ORX74234.1 - 3.9e-19 69.3 0.0 6.6e-18 65.3 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX74234.1 - 2.2e-16 59.9 0.0 1.6e-15 57.0 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX74234.1 - 1.8e-14 54.9 0.0 2.6e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ORX74234.1 - 5.5e-05 22.9 0.1 0.00016 21.4 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Ndr PF03096.14 ORX74234.1 - 6.9e-05 21.7 0.0 0.00019 20.2 0.0 1.7 2 0 0 2 2 2 1 Ndr family LIDHydrolase PF10230.9 ORX74234.1 - 0.0013 18.3 0.0 0.0059 16.2 0.0 2.0 2 1 0 2 2 2 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 ORX74234.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase DUF915 PF06028.11 ORX74234.1 - 0.013 14.9 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S28 PF05577.12 ORX74234.1 - 0.013 14.3 0.1 0.18 10.5 0.0 2.0 1 1 0 2 2 2 0 Serine carboxypeptidase S28 DUF2048 PF09752.9 ORX74234.1 - 0.039 13.1 0.0 0.084 12.0 0.0 1.5 2 0 0 2 2 2 0 Abhydrolase domain containing 18 Abhydrolase_8 PF06259.12 ORX74234.1 - 0.046 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_3 PF07859.13 ORX74234.1 - 0.053 13.4 0.0 0.13 12.1 0.0 1.7 1 1 1 2 2 2 0 alpha/beta hydrolase fold PGAP1 PF07819.13 ORX74234.1 - 0.067 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 ORX74234.1 - 0.069 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX74234.1 - 0.088 12.3 0.1 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 ORX74234.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF4472 PF14739.6 ORX74238.1 - 0.017 15.9 9.5 0.017 15.9 9.5 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) RasGAP_C PF03836.15 ORX74238.1 - 0.075 13.2 9.6 0.24 11.5 0.1 2.6 2 0 0 2 2 2 0 RasGAP C-terminus ADIP PF11559.8 ORX74238.1 - 0.14 12.2 30.9 1 9.4 4.7 2.6 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding 5_3_exonuc PF01367.20 ORX74238.1 - 0.5 11.0 7.0 13 6.4 0.0 2.8 2 1 1 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold PspA_IM30 PF04012.12 ORX74238.1 - 0.58 9.7 30.7 0.08 12.5 2.2 2.9 2 1 0 2 2 2 0 PspA/IM30 family TACC_C PF05010.14 ORX74238.1 - 0.87 9.3 22.3 4.3 7.1 3.5 2.9 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal IFT57 PF10498.9 ORX74238.1 - 3.8 6.4 16.0 0.24 10.3 9.5 1.9 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 FlaC_arch PF05377.11 ORX74238.1 - 4.8 7.6 5.0 21 5.6 0.2 3.4 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) MEDS PF14417.6 ORX74238.1 - 9.2 6.1 8.8 0.52 10.1 1.6 2.3 2 1 0 3 3 3 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain S-AdoMet_synt_M PF02772.16 ORX74239.1 - 1.9e-46 157.2 0.0 4e-46 156.2 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ORX74239.1 - 2.3e-46 156.5 0.1 4.4e-46 155.6 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_C PF02773.16 ORX74239.1 - 5.5e-40 136.6 5.7 1.6e-31 109.1 3.6 3.2 1 1 1 2 2 2 2 S-adenosylmethionine synthetase, C-terminal domain AdoMet_Synthase PF01941.19 ORX74239.1 - 0.026 13.3 0.1 0.081 11.7 0.0 1.7 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Sugar_tr PF00083.24 ORX74240.1 - 6.8e-78 262.5 21.5 1e-77 261.9 21.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX74240.1 - 3.2e-22 79.0 28.3 3.2e-22 79.0 28.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX74240.1 - 3.3e-06 25.8 1.6 3.3e-06 25.8 1.6 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 ORX74240.1 - 0.00083 17.8 1.9 0.001 17.5 0.2 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family PT-VENN PF04829.13 ORX74240.1 - 0.36 11.0 1.4 26 5.0 0.1 2.8 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif Vps39_1 PF10366.9 ORX74242.1 - 1.6e-25 89.4 1.1 6.1e-25 87.6 0.0 2.6 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 ORX74242.1 - 1.2e-14 54.7 0.3 3.3e-14 53.2 0.3 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 ORX74242.1 - 1.6e-13 50.9 0.0 5.1e-12 46.0 0.0 2.3 1 1 1 2 2 2 1 CNH domain Clathrin PF00637.20 ORX74242.1 - 2.9e-11 43.4 0.0 1.1e-06 28.6 0.0 2.8 3 0 0 3 3 3 2 Region in Clathrin and VPS GlgX_C PF18390.1 ORX74242.1 - 0.13 12.0 0.0 0.39 10.5 0.0 1.8 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain TPR_12 PF13424.6 ORX74242.1 - 0.72 10.2 4.9 1.2 9.5 1.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PGM_PMM_I PF02878.16 ORX74243.1 - 1e-14 54.4 0.0 3.2e-06 26.9 0.0 2.9 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 ORX74243.1 - 3.1e-10 40.1 0.3 1e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 ORX74243.1 - 0.019 15.6 0.5 0.41 11.3 0.5 2.7 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ABC_membrane_2 PF06472.15 ORX74244.1 - 2.7e-95 318.8 2.9 4.1e-95 318.2 2.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX74244.1 - 1.4e-12 48.3 0.0 7.4e-10 39.5 0.0 2.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX74244.1 - 0.0019 18.1 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX74244.1 - 0.039 14.3 0.1 0.38 11.1 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_18 PF13238.6 ORX74244.1 - 0.11 13.1 0.1 0.98 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ORX74244.1 - 0.13 11.7 0.0 4.1 6.8 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Hydrolase_6 PF13344.6 ORX74245.1 - 6.5e-23 80.8 0.0 3.4e-22 78.4 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX74245.1 - 3e-21 75.2 0.2 8.2e-21 73.9 0.1 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX74245.1 - 0.011 16.1 1.1 2.1 8.6 0.1 2.7 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Ion_trans_2 PF07885.16 ORX74246.1 - 0.0022 17.9 9.1 0.0048 16.8 9.1 1.6 1 1 0 1 1 1 1 Ion channel TssN PF17555.2 ORX74246.1 - 1.4 8.2 7.9 3.8 6.8 7.9 1.6 1 1 0 1 1 1 0 Type VI secretion system, TssN Tyr_Deacylase PF02580.16 ORX74247.1 - 3.3e-55 186.6 0.1 4.5e-55 186.1 0.1 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase BRO1 PF03097.18 ORX74248.1 - 8.3e-12 44.6 0.3 9.4e-12 44.4 0.3 1.1 1 0 0 1 1 1 1 BRO1-like domain Cu-oxidase_3 PF07732.15 ORX74249.1 - 1.3e-38 131.7 7.8 2.8e-32 111.2 0.3 4.2 4 1 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX74249.1 - 3.2e-35 120.8 9.1 6.2e-32 110.2 1.5 2.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX74249.1 - 1.8e-26 93.1 0.4 5e-23 82.0 0.0 3.2 3 0 0 3 3 3 2 Multicopper oxidase Transferase PF02458.15 ORX74250.1 - 6.3e-21 74.5 0.0 8.4e-15 54.3 0.0 2.0 2 0 0 2 2 2 2 Transferase family Pro_dh PF01619.18 ORX74251.1 - 5.9e-71 239.4 2.0 1.8e-70 237.8 2.0 1.7 1 1 0 1 1 1 1 Proline dehydrogenase EF-hand_1 PF00036.32 ORX74251.1 - 1.1e-10 40.2 0.5 0.00015 21.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ORX74251.1 - 1.6e-09 37.0 0.1 0.0008 19.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ORX74251.1 - 2e-06 27.0 1.3 0.041 13.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ORX74251.1 - 9.2e-06 26.0 0.1 5.2e-05 23.6 0.1 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ORX74251.1 - 0.00021 21.1 0.7 1.2 9.1 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 ORX74251.1 - 0.074 13.3 0.8 0.31 11.3 0.8 2.0 1 1 0 1 1 1 0 Dockerin type I domain VCBS PF13517.6 ORX74251.1 - 0.18 12.5 1.6 9.6 6.9 0.1 2.5 1 1 1 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF5522 PF17653.1 ORX74252.1 - 8.9e-25 86.4 2.6 1.3e-24 85.9 2.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5522) DUF807 PF05660.11 ORX74252.1 - 0.029 14.3 0.0 0.034 14.1 0.0 1.1 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) zf-LITAF-like PF10601.9 ORX74253.1 - 1.5e-16 60.4 1.4 2.2e-16 59.9 1.4 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-RING_7 PF02591.15 ORX74253.1 - 0.00026 21.1 0.4 0.044 14.0 0.0 2.7 2 0 0 2 2 2 1 C4-type zinc ribbon domain Cys_rich_CPXG PF14255.6 ORX74253.1 - 0.0097 15.8 0.3 1.1 9.2 0.0 2.4 2 0 0 2 2 2 1 Cysteine-rich CPXCG zf-CHCC PF10276.9 ORX74253.1 - 0.015 15.4 0.4 0.14 12.3 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger domain Zn_Tnp_IS1595 PF12760.7 ORX74253.1 - 0.018 15.0 0.7 1.4 9.0 0.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 ORX74253.1 - 0.049 13.1 2.6 2.7 7.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-Di19 PF05605.12 ORX74253.1 - 0.08 13.2 1.3 7.6 6.9 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 ORX74253.1 - 0.11 12.7 0.4 1.9 8.6 0.1 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Zn_clus PF00172.18 ORX74254.1 - 5.2e-12 45.7 11.9 7.2e-12 45.2 11.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 ORX74254.1 - 3.9 7.9 10.8 0.55 10.6 3.4 2.2 1 1 1 2 2 2 0 Opy2 protein ECH_1 PF00378.20 ORX74256.1 - 3.2e-32 111.8 0.1 3.9e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX74256.1 - 2.2e-12 47.2 0.1 6.4e-12 45.6 0.1 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 ORX74256.1 - 0.052 13.5 0.1 0.14 12.1 0.1 1.8 1 1 0 1 1 1 0 Peptidase family S49 CLP_protease PF00574.23 ORX74256.1 - 0.11 12.3 0.1 0.69 9.8 0.0 2.0 2 0 0 2 2 2 0 Clp protease Peptidase_M19 PF01244.21 ORX74256.1 - 0.12 11.6 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) Pro_isomerase PF00160.21 ORX74257.1 - 1.2e-48 165.4 0.2 1.5e-48 165.1 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Proteasome PF00227.26 ORX74260.1 - 9.2e-35 119.8 0.1 1e-34 119.7 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Cyclin PF08613.11 ORX74263.1 - 2.7e-28 99.3 0.5 3.3e-28 99.1 0.5 1.1 1 0 0 1 1 1 1 Cyclin FAD_binding_1 PF00667.20 ORX74264.1 - 1.3e-35 123.0 0.0 2.3e-35 122.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX74264.1 - 2.3e-28 99.2 0.1 9.3e-27 94.0 0.0 2.5 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX74264.1 - 4.7e-11 43.3 0.0 1.5e-10 41.7 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_NdrI PF07972.11 ORX74264.1 - 0.039 14.1 0.0 0.063 13.4 0.0 1.4 1 0 0 1 1 1 0 NrdI Flavodoxin like Flavodoxin_3 PF12641.7 ORX74264.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Spt20 PF12090.8 ORX74265.1 - 1.3 8.6 5.9 2.5 7.6 5.1 1.9 2 0 0 2 2 2 0 Spt20 family LIDHydrolase PF10230.9 ORX74266.1 - 6.7e-34 117.6 0.0 8.1e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 ORX74266.1 - 0.00062 19.1 0.0 0.0008 18.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioredoxin PF00085.20 ORX74267.1 - 5.2e-62 206.3 3.6 1e-26 92.9 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin OST3_OST6 PF04756.13 ORX74267.1 - 5.5e-09 35.8 0.5 6e-05 22.5 0.3 2.7 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ORX74267.1 - 8.6e-05 22.8 0.3 1.2 9.5 0.0 4.8 3 2 2 5 5 5 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ORX74267.1 - 0.00017 21.6 1.5 0.57 10.3 0.0 3.9 4 0 0 4 4 4 2 Thioredoxin domain AhpC-TSA PF00578.21 ORX74267.1 - 0.001 18.9 0.3 0.53 10.2 0.0 3.1 3 0 0 3 3 3 1 AhpC/TSA family Thioredoxin_9 PF14595.6 ORX74267.1 - 0.018 14.8 0.1 1.5 8.6 0.0 2.9 3 0 0 3 3 3 0 Thioredoxin DUF5389 PF17364.2 ORX74267.1 - 0.066 13.3 0.3 0.12 12.4 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5389) Thioredoxin_4 PF13462.6 ORX74267.1 - 0.31 11.2 7.1 4.2 7.5 0.0 4.3 3 2 1 4 4 4 0 Thioredoxin Prefoldin_2 PF01920.20 ORX74268.1 - 1.2e-14 54.2 0.4 1.2e-14 54.1 0.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Cullin_Nedd8 PF10557.9 ORX74268.1 - 0.037 14.1 0.1 0.045 13.8 0.1 1.2 1 0 0 1 1 1 0 Cullin protein neddylation domain DUF5457 PF17540.2 ORX74268.1 - 0.04 14.0 0.1 0.047 13.8 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5457) MMR_HSR1_Xtn PF16897.5 ORX74269.1 - 1.5e-43 147.1 0.1 2.6e-43 146.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ORX74269.1 - 1.3e-16 60.3 0.0 2.8e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ORX74269.1 - 4.1e-09 36.5 0.1 1e-08 35.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 ORX74269.1 - 0.00043 19.3 0.6 0.0075 15.3 0.2 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 ORX74269.1 - 0.0035 16.9 0.1 0.023 14.2 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ORX74269.1 - 0.0075 15.8 0.1 5.1 6.6 0.0 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Ploopntkinase3 PF18751.1 ORX74269.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 NB-ARC PF00931.22 ORX74269.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATP_bind_1 PF03029.17 ORX74269.1 - 0.14 11.9 1.1 10 5.8 0.2 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein CRAL_TRIO PF00650.20 ORX74270.1 - 2.2e-27 95.7 0.0 4.8e-27 94.6 0.0 1.6 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX74270.1 - 5.1e-14 52.2 0.1 1.9e-13 50.4 0.1 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX74270.1 - 0.00064 19.9 0.0 0.00099 19.3 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain APG6 PF04111.12 ORX74271.1 - 5.7e-34 117.6 0.1 4.7e-33 114.6 0.1 2.0 1 1 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 ORX74271.1 - 0.00092 19.8 13.2 0.032 14.8 5.7 2.4 1 1 1 2 2 2 2 Apg6 coiled-coil region vMSA PF00695.19 ORX74271.1 - 0.2 10.7 0.1 0.31 10.1 0.1 1.2 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus CRAL_TRIO PF00650.20 ORX74272.1 - 4.1e-26 91.6 0.0 9.5e-26 90.4 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX74272.1 - 2.2e-08 34.2 1.1 6.4e-08 32.7 0.4 2.1 1 1 1 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX74272.1 - 6.3e-05 23.2 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Methyltransf_11 PF08241.12 ORX74275.1 - 7.3e-05 23.3 0.1 0.00012 22.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX74275.1 - 0.008 16.9 0.1 0.014 16.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74275.1 - 0.023 15.4 0.1 0.063 14.0 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase domain F-box PF00646.33 ORX74278.1 - 0.00016 21.4 0.2 0.00044 20.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX74278.1 - 0.0079 16.1 0.2 0.0079 16.1 0.2 2.1 2 0 0 2 2 2 1 F-box-like PET10 PF17316.2 ORX74279.1 - 0.031 13.8 0.6 0.06 12.9 0.4 1.5 1 1 0 1 1 1 0 Petite colonies protein 10 Med15_fungi PF05397.12 ORX74279.1 - 0.053 13.8 0.5 0.12 12.7 0.5 1.5 1 0 0 1 1 1 0 Mediator complex subunit 15 Piwi PF02171.17 ORX74282.1 - 3.3e-98 328.6 0.1 4.4e-98 328.3 0.1 1.1 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 ORX74282.1 - 1.4e-15 57.3 0.0 3.1e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 ORX74282.1 - 1.1e-13 51.2 0.0 2.7e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 ORX74282.1 - 1.5e-13 51.5 0.0 3.5e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 ORX74282.1 - 2.6e-13 49.4 0.2 5.2e-13 48.5 0.2 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 ORX74282.1 - 1.2e-10 41.5 0.0 2.9e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain DMT_YdcZ PF04657.13 ORX74283.1 - 1.2e-30 106.7 13.1 1.4e-30 106.4 13.1 1.1 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ Sec10 PF07393.11 ORX74284.1 - 6.4e-12 44.7 0.0 1.3e-11 43.7 0.0 1.6 1 1 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 ORX74284.1 - 0.014 15.2 0.3 0.038 13.9 0.3 1.7 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 ORX74284.1 - 0.14 12.0 0.6 0.34 10.8 0.6 1.7 1 0 0 1 1 1 0 F-box domain Sec10 PF07393.11 ORX74285.1 - 5.8e-46 157.3 0.9 7.3e-46 156.9 0.9 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF4428 PF14471.6 ORX74285.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) PALP PF00291.25 ORX74286.1 - 4.2e-82 275.9 0.2 5.4e-82 275.5 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 ORX74286.1 - 2.2e-40 136.3 0.3 4.3e-19 68.1 0.1 2.7 2 1 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase DMT_YdcZ PF04657.13 ORX74287.1 - 1.5e-29 103.1 15.2 1.7e-29 102.8 15.2 1.1 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ DUF2065 PF09838.9 ORX74287.1 - 0.033 14.2 0.5 0.033 14.2 0.5 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2065) EamA PF00892.20 ORX74287.1 - 0.29 11.3 15.9 0.36 11.0 15.9 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF3413 PF11893.8 ORX74287.1 - 0.64 9.1 5.5 1.7 7.8 5.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3413) DMT_YdcZ PF04657.13 ORX74288.1 - 8.3e-24 84.4 15.9 9.7e-24 84.2 15.9 1.0 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ EamA PF00892.20 ORX74288.1 - 0.093 12.9 11.3 0.14 12.3 11.3 1.3 1 1 0 1 1 1 0 EamA-like transporter family MFS_1 PF07690.16 ORX74290.1 - 1.8e-15 56.7 26.6 2.1e-15 56.6 25.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ORX74290.1 - 1.4e-14 54.1 6.8 4.4e-14 52.5 6.8 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Helicase_C PF00271.31 ORX74291.1 - 3.7e-13 49.8 0.0 9.2e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 ORX74291.1 - 1e-09 38.7 0.0 2.1e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 RWD domain HA2 PF04408.23 ORX74291.1 - 4.3e-09 36.6 5.5 7.9e-09 35.8 0.0 3.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX74291.1 - 9.3e-08 32.3 0.0 2.3e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold PNPase_C PF12111.8 ORX74291.1 - 0.096 12.1 0.1 0.32 10.4 0.1 1.9 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal DND1_DSRM PF14709.7 ORX74291.1 - 0.16 12.2 0.0 0.48 10.7 0.0 1.9 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 ParA PF10609.9 ORX74292.1 - 9.6e-92 306.9 0.0 1.5e-91 306.3 0.0 1.3 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ORX74292.1 - 4.3e-11 43.0 0.0 4e-08 33.4 0.0 2.6 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ORX74292.1 - 4.9e-06 26.6 0.3 0.00014 21.8 0.3 2.2 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 ORX74292.1 - 2.2e-05 23.8 0.7 0.00012 21.4 0.3 2.1 1 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 ORX74292.1 - 0.00026 20.6 0.0 0.38 10.1 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 ORX74292.1 - 0.00037 20.1 0.0 0.00059 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 ORX74292.1 - 0.0012 18.4 0.1 0.012 15.1 0.1 2.0 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MipZ PF09140.11 ORX74292.1 - 0.0015 17.9 0.0 0.0033 16.7 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 ORX74292.1 - 0.0024 17.7 0.0 0.018 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX74292.1 - 0.02 14.8 0.1 0.036 14.0 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase MeaB PF03308.16 ORX74292.1 - 0.045 12.7 0.1 0.066 12.2 0.1 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 ORX74292.1 - 0.1 11.8 0.2 0.16 11.1 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain VirE PF05272.11 ORX74292.1 - 0.25 11.1 0.0 0.4 10.4 0.0 1.2 1 0 0 1 1 1 0 Virulence-associated protein E Pam17 PF08566.10 ORX74293.1 - 1.9e-40 138.4 0.1 5.6e-40 136.9 0.1 1.7 1 1 0 1 1 1 1 Mitochondrial import protein Pam17 BCS1_N PF08740.11 ORX74293.1 - 0.058 13.4 1.5 0.12 12.3 1.2 1.6 2 0 0 2 2 2 0 BCS1 N terminal UPF0121 PF03661.13 ORX74294.1 - 9.5e-25 87.4 8.8 1.1e-21 77.4 1.0 2.2 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0121) His_Phos_1 PF00300.22 ORX74295.1 - 2.6e-11 43.6 0.0 2.4e-10 40.4 0.0 2.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ribosomal_S7 PF00177.21 ORX74296.1 - 1.3e-33 115.7 0.4 1.6e-33 115.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e IFRD PF05004.13 ORX74298.1 - 9.7e-51 172.7 11.7 1.5e-50 172.1 11.7 1.3 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 ORX74298.1 - 0.018 15.3 0.9 15 6.2 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat Trehalase PF01204.18 ORX74299.1 - 7.3e-169 562.9 0.0 8.7e-169 562.6 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 ORX74299.1 - 1e-14 53.9 0.2 1.9e-14 53.1 0.2 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Sua5_yciO_yrdC PF01300.18 ORX74300.1 - 5.7e-44 149.7 0.0 1.4e-42 145.2 0.0 2.3 1 1 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 ORX74300.1 - 5.3e-31 107.9 0.0 7.6e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding MFS_1 PF07690.16 ORX74301.1 - 1.5e-13 50.4 46.5 4.2e-11 42.4 19.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipoprotein_X PF03305.13 ORX74302.1 - 0.0083 15.9 0.1 0.0092 15.8 0.1 1.1 1 0 0 1 1 1 1 Mycoplasma MG185/MG260 protein Mre11_DNA_bind PF04152.14 ORX74305.1 - 9.8e-41 139.9 0.2 1.7e-40 139.1 0.2 1.4 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ORX74305.1 - 4.5e-14 53.4 1.3 6.8e-14 52.8 1.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX74305.1 - 9.5e-07 29.1 0.0 2.1e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain UNC-93 PF05978.16 ORX74307.1 - 5.2e-05 23.0 1.2 5.2e-05 23.0 1.2 1.9 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 UcrQ PF02939.16 ORX74307.1 - 0.041 13.8 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 UcrQ family UNC-93 PF05978.16 ORX74308.1 - 5e-06 26.3 4.4 5e-06 26.3 4.4 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 RHD3 PF05879.12 ORX74309.1 - 4.5e-217 722.7 3.9 8.6e-191 635.9 3.7 2.0 2 0 0 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 ORX74309.1 - 1.1e-06 28.7 0.0 3e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.19 ORX74309.1 - 5.5e-06 25.8 0.0 1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 ORX74309.1 - 1.9e-05 24.8 0.0 4.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 ORX74309.1 - 0.0006 20.1 0.1 0.0024 18.1 0.0 2.2 2 1 1 3 3 3 1 AAA domain DUF2523 PF10734.9 ORX74309.1 - 0.013 16.0 0.1 0.18 12.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2523) Septin PF00735.18 ORX74309.1 - 0.034 13.4 0.0 0.073 12.3 0.0 1.5 1 0 0 1 1 1 0 Septin DUF445 PF04286.12 ORX74309.1 - 0.079 12.7 1.5 0.12 12.1 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Acetyltransf_1 PF00583.25 ORX74310.1 - 0.0033 17.7 0.0 0.0086 16.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX74310.1 - 0.0078 16.6 0.0 0.016 15.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX74310.1 - 0.045 13.7 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_10 PF13673.7 ORX74310.1 - 0.046 13.6 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GAS PF13851.6 ORX74311.1 - 9.4e-05 21.8 16.0 0.00037 19.9 6.7 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ORX74311.1 - 0.00093 19.2 12.0 0.04 13.9 10.8 2.5 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 ORX74311.1 - 0.00098 19.3 12.5 0.7 10.2 1.7 4.0 1 1 2 3 3 3 2 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 ORX74311.1 - 0.0029 17.8 16.5 0.026 14.7 2.1 3.2 1 1 2 3 3 3 1 Tropomyosin like Spectrin PF00435.21 ORX74311.1 - 0.0046 17.4 3.9 0.0046 17.4 3.9 3.0 2 1 0 3 3 2 1 Spectrin repeat Atg14 PF10186.9 ORX74311.1 - 0.0081 15.3 8.8 0.022 13.9 9.0 1.6 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 ORX74311.1 - 0.0091 14.9 21.5 0.016 14.1 12.3 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein HBM PF16591.5 ORX74311.1 - 0.012 15.1 22.1 0.04 13.4 22.2 1.8 1 1 0 1 1 1 0 Helical bimodular sensor domain HAP1_N PF04849.13 ORX74311.1 - 0.021 14.1 20.5 0.076 12.2 20.5 2.2 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DUF5082 PF16888.5 ORX74311.1 - 0.028 14.7 11.2 0.94 9.8 1.8 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) AAA_13 PF13166.6 ORX74311.1 - 0.038 12.7 8.2 0.061 12.0 8.2 1.4 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.12 ORX74311.1 - 0.065 13.3 13.3 0.85 9.7 4.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 ORX74311.1 - 0.076 12.8 18.2 0.38 10.6 10.8 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Jnk-SapK_ap_N PF09744.9 ORX74311.1 - 0.087 13.0 22.4 0.25 11.5 9.2 3.7 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 BCAS2 PF05700.11 ORX74311.1 - 0.37 10.4 16.8 0.093 12.4 5.1 2.5 2 1 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) BRE1 PF08647.11 ORX74311.1 - 0.46 10.6 14.4 3.2 7.9 4.6 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase FapA PF03961.13 ORX74311.1 - 0.74 8.3 7.9 0.63 8.6 2.0 2.1 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF2203 PF09969.9 ORX74311.1 - 1.2 9.9 14.2 8.8 7.1 2.3 3.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Lebercilin PF15619.6 ORX74311.1 - 1.3 8.6 21.4 5.2 6.7 17.7 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 ORX74311.1 - 1.5 9.0 8.4 6.7 6.9 1.4 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 ORX74311.1 - 1.5 8.6 9.7 21 4.9 1.8 3.7 1 1 2 3 3 3 0 Phage minor structural protein GP20 NPV_P10 PF05531.12 ORX74311.1 - 2.3 8.7 12.4 7.7 7.1 0.1 4.8 1 1 3 5 5 5 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 ORX74311.1 - 2.5 8.2 27.1 0.27 11.3 3.2 3.8 1 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein KLRAQ PF10205.9 ORX74311.1 - 2.9 8.2 13.6 7.1 6.9 1.8 3.6 1 1 3 4 4 4 0 Predicted coiled-coil domain-containing protein Allexi_40kDa PF05549.11 ORX74311.1 - 3.2 7.2 7.6 8.1 5.9 0.2 2.7 1 1 3 4 4 4 0 Allexivirus 40kDa protein DUF4200 PF13863.6 ORX74311.1 - 3.5 8.1 17.4 2.6 8.5 4.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF724 PF05266.14 ORX74311.1 - 3.7 7.3 14.9 1.5 8.7 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Prominin PF05478.11 ORX74311.1 - 3.7 5.4 8.7 0.76 7.7 1.3 2.0 1 1 1 2 2 2 0 Prominin APG6_N PF17675.1 ORX74311.1 - 4.3 7.9 21.2 8.3 7.0 4.7 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 ORX74311.1 - 4.8 7.4 19.0 0.74 10.0 8.3 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 ORX74311.1 - 4.9 6.4 24.2 0.46 9.7 2.5 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Csm1_N PF18504.1 ORX74311.1 - 5.1 7.5 16.0 1.8 9.0 1.7 4.4 1 1 2 4 4 4 0 Csm1 N-terminal domain DUF2959 PF11172.8 ORX74311.1 - 5.4 7.1 14.8 7.6 6.6 0.6 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF2959) Golgin_A5 PF09787.9 ORX74311.1 - 5.7 6.3 22.2 3.4 7.0 4.9 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Spc24 PF08286.11 ORX74311.1 - 6.3 7.1 14.2 16 5.8 4.8 3.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 XhlA PF10779.9 ORX74311.1 - 9 6.6 12.6 13 6.1 1.8 3.8 2 2 2 4 4 4 0 Haemolysin XhlA WD40 PF00400.32 ORX74312.1 - 1.1e-17 64.1 0.6 4.5e-06 27.3 0.2 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74312.1 - 0.0063 16.8 0.0 1.6 9.1 0.0 3.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain ANTH PF07651.16 ORX74313.1 - 1.1e-29 103.3 1.1 2e-29 102.5 1.1 1.4 1 0 0 1 1 1 1 ANTH domain DUF508 PF04370.12 ORX74313.1 - 0.0076 16.0 0.2 0.035 13.8 0.2 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF508) DUF1018 PF06252.12 ORX74313.1 - 6.1 7.9 8.1 12 6.9 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) adh_short PF00106.25 ORX74314.1 - 1.5e-36 125.7 2.5 3e-35 121.5 2.5 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX74314.1 - 8.9e-28 97.4 1.7 9.5e-27 94.1 1.7 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX74314.1 - 3.1e-07 30.5 0.4 6.2e-07 29.5 0.1 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ORX74314.1 - 1.1e-05 25.0 0.5 2.2e-05 24.1 0.5 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Abhydrolase_1 PF00561.20 ORX74315.1 - 4.7e-06 26.5 0.0 0.034 13.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX74315.1 - 5.6e-05 22.5 0.0 0.00017 21.0 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74316.1 - 1e-06 28.6 0.0 0.022 14.4 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX74316.1 - 0.0066 15.7 0.0 0.31 10.2 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74317.1 - 6.6e-09 35.8 0.0 1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX74317.1 - 1.7e-06 27.5 0.0 2.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX74317.1 - 1.6e-05 25.7 0.0 3.5e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family zf-Tim10_DDP PF02953.15 ORX74318.1 - 5.7e-21 73.9 0.1 7e-21 73.6 0.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger SPOUT_MTase PF02590.17 ORX74318.1 - 0.095 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase Es2 PF09751.9 ORX74319.1 - 4.7e-20 72.7 5.2 2.7e-10 40.6 0.6 2.0 1 1 1 2 2 2 2 Nuclear protein Es2 FAD_binding_5 PF00941.21 ORX74319.1 - 0.087 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase Ubie_methyltran PF01209.18 ORX74320.1 - 4.2e-14 52.5 0.0 4.7e-11 42.5 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ORX74320.1 - 3.1e-06 27.8 0.0 7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX74320.1 - 8e-06 26.4 0.0 1.4e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX74320.1 - 0.0035 17.1 0.0 0.0066 16.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74320.1 - 0.16 12.8 0.0 0.37 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain SerH PF06873.11 ORX74321.1 - 2.2 7.0 33.3 2.8 6.6 33.3 1.1 1 0 0 1 1 1 0 Cell surface immobilisation antigen SerH RSN1_7TM PF02714.15 ORX74323.1 - 5.4e-32 111.2 20.0 1e-30 107.0 5.8 2.7 2 1 1 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX74323.1 - 3.3e-31 108.2 1.9 3e-19 69.3 0.4 2.9 2 0 0 2 2 2 2 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX74323.1 - 1.1e-21 77.9 0.1 2.3e-21 76.8 0.1 1.6 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Anoctamin PF04547.12 ORX74323.1 - 0.0028 16.6 2.3 0.0042 16.0 1.1 1.6 1 1 0 1 1 1 1 Calcium-activated chloride channel IP_trans PF02121.18 ORX74324.1 - 1.2e-81 273.9 3.0 2.5e-81 272.9 3.0 1.5 1 1 0 1 1 1 1 Phosphatidylinositol transfer protein zf-U1 PF06220.12 ORX74325.1 - 6.4e-22 77.0 2.3 9.3e-22 76.5 2.3 1.3 1 0 0 1 1 1 1 U1 zinc finger Mst1_SARAH PF11629.8 ORX74328.1 - 0.12 12.5 2.7 0.34 11.0 1.0 2.5 1 1 1 2 2 2 0 C terminal SARAH domain of Mst1 HSCB_C PF07743.13 ORX74328.1 - 1.6 9.2 5.0 0.76 10.3 1.2 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Clat_adaptor_s PF01217.20 ORX74329.1 - 4.3e-46 156.4 1.5 5e-46 156.2 1.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain bVLRF1 PF18826.1 ORX74330.1 - 3.2e-46 156.9 0.7 7.3e-46 155.7 0.0 2.0 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor VATC PF18716.1 ORX74330.1 - 1.6e-07 31.0 2.5 3.3e-07 30.1 2.5 1.5 1 0 0 1 1 1 1 Vms1-associating treble clef domain Ank_5 PF13857.6 ORX74330.1 - 0.0016 18.7 0.0 0.004 17.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) CAF-1_p150 PF11600.8 ORX74330.1 - 0.012 15.3 25.1 0.026 14.2 25.1 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ank_3 PF13606.6 ORX74330.1 - 0.016 15.7 0.0 0.044 14.3 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat DUF3915 PF13054.6 ORX74330.1 - 3 7.9 6.6 6.9 6.7 6.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Trypsin PF00089.26 ORX74331.1 - 1.1e-28 100.6 1.9 1.2e-28 100.4 1.9 1.1 1 0 0 1 1 1 1 Trypsin Sugar_tr PF00083.24 ORX74332.1 - 3.4e-89 299.8 26.0 4.2e-89 299.5 26.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX74332.1 - 8.8e-23 80.8 72.4 3.7e-21 75.5 38.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2398 PF09661.10 ORX74332.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2398) Pullulanase_Ins PF18494.1 ORX74333.1 - 0.029 14.8 0.1 0.11 13.0 0.0 1.9 2 1 0 2 2 2 0 Pullulanase Ins domain NitrOD5 PF11537.8 ORX74333.1 - 0.054 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Nitrosopumilus output domain 5 CD34_antigen PF06365.12 ORX74334.1 - 0.0043 16.7 0.0 0.0046 16.6 0.0 1.1 1 0 0 1 1 1 1 CD34/Podocalyxin family VSP PF03302.13 ORX74335.1 - 4.9e-09 35.5 0.5 7.3e-09 35.0 0.5 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF2207 PF09972.9 ORX74335.1 - 0.00028 19.8 0.0 0.00042 19.2 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) PTP_tm PF18861.1 ORX74335.1 - 0.0033 17.4 0.1 0.01 15.8 0.0 1.8 2 0 0 2 2 2 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J UPF0154 PF03672.13 ORX74335.1 - 0.0089 16.0 0.4 0.019 15.0 0.4 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) Podoplanin PF05808.11 ORX74335.1 - 0.011 15.8 13.4 0.011 15.8 13.4 1.6 1 1 0 1 1 1 0 Podoplanin TPR_21 PF09976.9 ORX74335.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain stn_TNFRSF12A PF12191.8 ORX74335.1 - 0.026 14.7 1.7 0.043 14.0 0.0 2.2 2 1 1 3 3 3 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF3149 PF11346.8 ORX74335.1 - 0.032 13.9 0.9 0.067 12.8 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) SCF PF02404.15 ORX74335.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Stem cell factor DUF4366 PF14283.6 ORX74335.1 - 0.11 12.5 2.5 0.51 10.4 2.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) CYYR1 PF10873.8 ORX74335.1 - 0.12 12.9 0.1 0.12 12.9 0.1 3.7 3 1 1 4 4 2 0 Cysteine and tyrosine-rich protein 1 SKG6 PF08693.10 ORX74335.1 - 0.14 11.6 3.4 0.59 9.6 3.4 2.1 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RIFIN PF02009.16 ORX74335.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Rifin EphA2_TM PF14575.6 ORX74335.1 - 0.19 12.6 0.0 1.3 10.0 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 ORX74335.1 - 0.8 9.1 4.7 2.8 7.3 4.7 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5305) CD99L2 PF12301.8 ORX74335.1 - 1.6 9.0 16.4 9.3 6.5 16.0 2.3 1 1 0 1 1 1 0 CD99 antigen like protein 2 Peptidase_M1 PF01433.20 ORX74336.1 - 3.2e-85 285.1 1.3 5.4e-85 284.4 1.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ORX74336.1 - 2.4e-78 263.9 7.3 7.7e-78 262.2 4.3 2.2 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ORX74336.1 - 4.6e-53 180.2 0.0 2.2e-52 177.9 0.0 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2884 PF11101.8 ORX74336.1 - 0.0029 17.1 0.0 0.0073 15.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2884) DUF45 PF01863.17 ORX74336.1 - 0.15 12.0 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF45 AAA-ATPase_like PF09820.9 ORX74337.1 - 5.2e-12 45.8 0.0 1.3e-11 44.4 0.0 1.7 1 1 0 1 1 1 1 Predicted AAA-ATPase PUF PF00806.19 ORX74338.1 - 1.2e-18 65.7 0.0 1.8e-05 24.1 0.1 3.3 3 0 0 3 3 3 3 Pumilio-family RNA binding repeat EFTUD2 PF16004.5 ORX74338.1 - 0.051 14.2 0.1 1.2 9.8 0.0 2.1 1 1 1 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF4988 PF16378.5 ORX74338.1 - 0.081 12.6 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function Thioredoxin_4 PF13462.6 ORX74339.1 - 4.7e-05 23.6 0.0 0.00049 20.3 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ORX74339.1 - 0.00078 19.3 0.3 0.14 11.9 0.0 2.2 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 ORX74339.1 - 0.1 13.1 0.0 1.5 9.3 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain PEMT PF04191.13 ORX74340.1 - 5e-32 110.4 4.3 5e-32 110.4 4.3 2.0 3 0 0 3 3 3 1 Phospholipid methyltransferase FPL PF09758.9 ORX74342.1 - 2.1e-48 164.1 0.8 3.5e-48 163.4 0.8 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF2019 PF09450.10 ORX74342.1 - 0.044 13.7 0.3 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2019) PIN_4 PF13638.6 ORX74343.1 - 3e-12 47.0 0.0 6.3e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 PIN domain EST1_DNA_bind PF10373.9 ORX74343.1 - 5.6e-05 22.8 0.1 0.0001 21.9 0.1 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain PIN_9 PF18477.1 ORX74343.1 - 0.0029 17.9 0.0 0.21 11.9 0.0 2.6 1 1 0 1 1 1 1 PIN like domain EST1 PF10374.9 ORX74343.1 - 0.066 13.8 0.2 3.5 8.3 0.6 2.5 1 1 1 2 2 2 0 Telomerase activating protein Est1 14-3-3 PF00244.20 ORX74343.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 14-3-3 protein HD_3 PF13023.6 ORX74344.1 - 1.5e-47 161.6 0.2 1.7e-47 161.4 0.2 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 ORX74344.1 - 6.6e-12 45.5 0.1 9e-12 45.1 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 ORX74344.1 - 6.2e-05 23.2 0.5 0.00012 22.3 0.5 1.5 1 0 0 1 1 1 1 HD domain PTH2 PF01981.16 ORX74345.1 - 6.6e-47 158.6 0.1 7.8e-47 158.4 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF1949 PF09186.11 ORX74345.1 - 0.032 14.1 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1949) DEAD PF00270.29 ORX74346.1 - 1.6e-44 151.8 0.1 2.9e-44 150.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX74346.1 - 3e-31 108.0 0.2 1.4e-30 105.9 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX74346.1 - 1.4e-06 28.4 0.0 2.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ORX74346.1 - 0.0046 16.7 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ORX74346.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.6 ORX74346.1 - 0.026 14.8 0.4 0.048 14.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain CMS1 PF14617.6 ORX74346.1 - 0.075 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF3419 PF11899.8 ORX74346.1 - 0.083 12.1 0.1 0.53 9.4 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3419) TniB PF05621.11 ORX74346.1 - 0.1 12.0 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 ORX74346.1 - 0.21 11.8 1.5 0.8 10.0 1.5 2.0 1 1 0 1 1 1 0 AAA domain eIF-5_eIF-2B PF01873.17 ORX74347.1 - 5e-39 132.8 0.0 8.7e-39 132.0 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 ORX74347.1 - 1.4e-14 53.9 0.0 2.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon baeRF_family12 PF18856.1 ORX74347.1 - 0.05 14.2 0.2 0.12 13.0 0.2 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Pkinase PF00069.25 ORX74348.1 - 1.9e-28 99.6 0.0 1.1e-14 54.5 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74348.1 - 1.9e-12 47.0 0.0 3.2e-07 29.9 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX74348.1 - 0.0037 16.6 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ORX74348.1 - 0.013 15.4 0.3 0.25 11.2 0.1 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family RRM_1 PF00076.22 ORX74349.1 - 3.9e-06 26.6 0.5 0.00074 19.3 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 ORX74349.1 - 0.0001 22.6 0.1 0.00023 21.4 0.1 1.6 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.6 ORX74349.1 - 0.00022 21.2 0.0 0.0035 17.3 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Complex1_LYR_2 PF13233.6 ORX74349.1 - 0.0004 21.1 0.4 0.061 14.1 0.0 2.6 2 0 0 2 2 2 1 Complex1_LYR-like PHM7_cyt PF14703.6 ORX74349.1 - 0.0051 17.1 6.3 0.0099 16.1 0.4 3.2 2 1 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Ribosomal_60s PF00428.19 ORX74349.1 - 7.2 7.3 16.3 6 7.5 0.7 3.8 4 0 0 4 4 4 0 60s Acidic ribosomal protein Orbi_VP4 PF05059.12 ORX74350.1 - 0.12 10.3 0.2 0.16 10.0 0.2 1.1 1 0 0 1 1 1 0 Orbivirus VP4 core protein Band_7 PF01145.25 ORX74351.1 - 6.6e-27 94.7 1.2 9.2e-27 94.2 1.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ORX74351.1 - 0.0035 17.1 0.1 0.0053 16.5 0.1 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family ATG_C PF09333.11 ORX74354.1 - 0.00074 19.8 0.2 0.78 10.1 0.0 3.0 1 1 1 2 2 2 2 Autophagy-related protein C terminal domain GCSF PF16647.5 ORX74354.1 - 0.11 12.3 0.6 15 5.4 0.0 3.0 3 0 0 3 3 3 0 Granulocyte colony-stimulating factor Yippee-Mis18 PF03226.14 ORX74355.1 - 6.6e-13 48.8 1.8 8.4e-13 48.4 1.8 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Vps36_ESCRT-II PF11605.8 ORX74355.1 - 0.0026 17.9 0.0 0.1 12.8 0.0 2.1 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 CCER1 PF15482.6 ORX74355.1 - 0.064 13.2 0.0 0.08 12.8 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Ribosomal_L1 PF00687.21 ORX74356.1 - 3.7e-33 115.0 0.0 4.7e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family tRNA_synt_1c_R1 PF04558.15 ORX74356.1 - 0.066 13.2 0.1 0.098 12.7 0.1 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Kinesin PF00225.23 ORX74357.1 - 3.2e-101 338.6 0.0 1.3e-100 336.6 0.0 1.9 1 1 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ORX74357.1 - 2.4e-25 89.7 13.7 5.8e-22 78.7 2.8 3.6 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 ORX74357.1 - 2.4e-23 82.7 0.0 5.5e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF3694 PF12473.8 ORX74357.1 - 2.3e-08 34.9 0.0 1.6e-06 28.8 0.0 2.8 1 1 0 1 1 1 1 Kinesin protein FHA PF00498.26 ORX74357.1 - 2.6e-05 24.5 1.0 0.00025 21.3 0.0 3.0 3 0 0 3 3 3 1 FHA domain PH PF00169.29 ORX74357.1 - 0.00025 21.5 0.0 0.00064 20.2 0.0 1.6 1 0 0 1 1 1 1 PH domain ALMT PF11744.8 ORX74358.1 - 2e-14 53.3 10.0 2.2e-12 46.6 7.0 2.7 3 0 0 3 3 3 2 Aluminium activated malate transporter ArAE_2_N PF10337.9 ORX74358.1 - 1.5e-11 44.0 8.7 4.8e-06 25.9 0.0 2.7 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 ORX74358.1 - 2.8e-11 43.6 17.2 2.8e-11 43.6 17.2 3.0 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 ORX74358.1 - 0.0011 17.6 16.5 0.03 12.9 0.0 2.8 2 1 0 2 2 2 2 Fusaric acid resistance protein family ArAE_2 PF10334.9 ORX74358.1 - 0.0019 18.1 0.1 0.024 14.5 0.1 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 DUF4590 PF15257.6 ORX74358.1 - 0.04 13.8 0.6 0.092 12.7 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4590) SPT_ssu-like PF11779.8 ORX74358.1 - 8.7 6.1 12.2 1.3 8.7 0.5 3.4 3 0 0 3 3 3 0 Small subunit of serine palmitoyltransferase-like Ysc84 PF04366.12 ORX74359.1 - 7.7e-33 113.0 0.3 1.4e-32 112.1 0.3 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator p450 PF00067.22 ORX74360.1 - 1.1e-52 179.4 0.0 3.3e-52 177.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 MetJ PF01340.20 ORX74361.1 - 0.14 12.2 0.1 0.39 10.7 0.1 1.7 2 0 0 2 2 2 0 Met Apo-repressor, MetJ zf-RING_2 PF13639.6 ORX74364.1 - 1.4e-12 47.7 5.8 1.4e-12 47.7 5.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX74364.1 - 3.7e-09 36.3 6.2 3.7e-09 36.3 6.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX74364.1 - 4.2e-08 32.8 3.2 8.8e-08 31.8 3.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX74364.1 - 5.6e-08 33.0 7.9 5.6e-08 33.0 7.9 2.0 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX74364.1 - 4e-06 26.7 4.5 9.7e-06 25.5 4.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX74364.1 - 4.1e-06 26.6 6.2 4.1e-06 26.6 6.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX74364.1 - 7.3e-06 25.9 2.5 1.6e-05 24.9 2.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX74364.1 - 0.00092 19.2 3.0 0.00092 19.2 3.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX74364.1 - 0.0071 16.2 6.0 0.0071 16.2 6.0 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ORX74364.1 - 0.0092 16.1 8.5 0.15 12.3 8.5 2.5 1 1 0 1 1 1 1 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ORX74364.1 - 0.011 15.3 6.2 0.025 14.2 6.2 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DivIC PF04977.15 ORX74364.1 - 0.028 14.2 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Septum formation initiator PHD PF00628.29 ORX74364.1 - 0.048 13.6 7.2 0.094 12.6 7.2 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 ORX74364.1 - 0.62 10.4 8.5 1.6 9.1 8.5 1.8 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.6 ORX74364.1 - 1.4 8.9 8.6 5.7 6.9 8.8 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Peptidase_C3G PF12381.8 ORX74365.1 - 0.078 12.4 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase LapA_dom PF06305.11 ORX74365.1 - 0.099 12.5 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Rota_VP2 PF05087.12 ORX74365.1 - 0.12 10.4 0.1 0.13 10.4 0.1 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein Spore_III_AB PF09548.10 ORX74365.1 - 0.18 11.9 0.6 0.24 11.5 0.6 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) CD34_antigen PF06365.12 ORX74365.1 - 0.24 11.0 0.1 0.28 10.7 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family zf-RING_2 PF13639.6 ORX74367.1 - 1e-13 51.4 4.9 2e-13 50.5 4.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX74367.1 - 5.4e-11 42.0 2.2 5.4e-11 42.0 2.2 2.2 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX74367.1 - 2.8e-10 40.3 8.2 4.2e-10 39.7 8.2 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX74367.1 - 5.8e-10 38.9 3.9 1e-09 38.1 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX74367.1 - 1.1e-07 31.7 3.1 1.8e-07 31.0 3.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX74367.1 - 1.3e-07 31.4 2.9 2.5e-07 30.4 2.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX74367.1 - 1.8e-06 27.9 6.5 4.1e-06 26.7 0.6 2.6 3 0 0 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX74367.1 - 8.9e-06 25.5 3.5 1.9e-05 24.5 3.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX74367.1 - 1.9e-05 24.7 3.9 2.8e-05 24.1 3.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ORX74367.1 - 2.5e-05 24.1 1.7 4.7e-05 23.2 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) YdjO PF14169.6 ORX74367.1 - 0.0003 20.5 0.3 0.1 12.4 0.0 2.4 2 0 0 2 2 2 1 Cold-inducible protein YdjO Zn_ribbon_17 PF17120.5 ORX74367.1 - 0.0029 17.2 6.5 0.0029 17.2 6.5 2.0 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX74367.1 - 0.0055 16.8 3.0 0.018 15.2 3.0 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 ORX74367.1 - 0.025 14.7 1.5 0.025 14.7 1.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-RING_4 PF14570.6 ORX74367.1 - 0.032 14.0 2.7 0.032 14.0 2.7 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain NAD_binding_6 PF08030.12 ORX74367.1 - 0.033 14.3 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Ferric reductase NAD binding domain PHD PF00628.29 ORX74367.1 - 0.07 13.0 4.3 0.14 12.1 4.3 1.6 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 ORX74367.1 - 0.31 11.2 5.7 2.4 8.4 5.7 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ORX74367.1 - 0.34 11.1 9.3 0.091 12.9 5.2 2.1 1 1 1 2 2 2 0 RING-variant domain zf-RING-like PF08746.11 ORX74367.1 - 1.4 9.3 10.5 4.1 7.8 10.5 1.9 1 1 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 ORX74367.1 - 3 8.0 7.4 1.1 9.4 3.6 2.2 2 1 0 2 2 2 0 KIAA1045 RING finger zinc_ribbon_16 PF17034.5 ORX74367.1 - 4.5 7.5 9.0 1.4 9.1 3.1 2.1 1 1 1 2 2 2 0 Zinc-ribbon like family Band_7 PF01145.25 ORX74368.1 - 3.6e-22 79.2 0.0 5.3e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ORX74368.1 - 0.0058 16.4 0.0 0.0091 15.7 0.0 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family eRF1_3 PF03465.15 ORX74368.1 - 0.026 15.0 0.3 0.91 10.0 0.3 2.4 1 1 0 1 1 1 0 eRF1 domain 3 PKD_channel PF08016.12 ORX74370.1 - 0.046 12.4 0.2 0.052 12.2 0.2 1.0 1 0 0 1 1 1 0 Polycystin cation channel DUF1652 PF07865.11 ORX74370.1 - 0.047 13.5 0.2 0.078 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1652) GSH_synthase PF03199.15 ORX74370.1 - 0.19 12.2 0.0 0.22 12.0 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic glutathione synthase ATP-synt_D PF01813.17 ORX74372.1 - 0.00012 22.0 0.7 0.00022 21.1 0.7 1.5 1 0 0 1 1 1 1 ATP synthase subunit D APG6_N PF17675.1 ORX74372.1 - 0.0081 16.7 7.5 0.0081 16.7 7.5 2.6 2 0 0 2 2 2 1 Apg6 coiled-coil region DUF773 PF05600.12 ORX74372.1 - 0.033 13.0 2.9 0.062 12.0 2.9 1.4 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Herpes_UL6 PF01763.16 ORX74372.1 - 0.054 12.0 2.1 0.036 12.6 0.4 1.5 2 0 0 2 2 2 0 Herpesvirus UL6 like Mod_r PF07200.13 ORX74372.1 - 0.091 12.9 10.6 0.074 13.2 4.9 2.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein HAUS-augmin3 PF14932.6 ORX74372.1 - 0.34 10.5 18.7 0.031 13.9 10.9 2.7 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 Atg14 PF10186.9 ORX74372.1 - 0.65 9.0 6.8 0.17 11.0 2.5 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 ORX74372.1 - 0.69 10.1 14.2 0.68 10.1 7.1 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TMF_DNA_bd PF12329.8 ORX74372.1 - 0.99 9.4 10.4 1 9.4 7.3 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.14 ORX74372.1 - 1.3 8.8 9.4 0.33 10.8 4.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) YabA PF06156.13 ORX74372.1 - 1.7 9.3 5.9 1.6 9.4 2.3 2.4 2 0 0 2 2 2 0 Initiation control protein YabA XkdW PF09636.10 ORX74372.1 - 2 8.5 4.6 8.4 6.5 1.1 2.4 2 0 0 2 2 2 0 XkdW protein ZapB PF06005.12 ORX74372.1 - 2.4 8.7 17.4 0.04 14.3 6.0 2.8 3 0 0 3 3 3 0 Cell division protein ZapB Spc24 PF08286.11 ORX74372.1 - 8.1 6.7 8.0 3.7 7.8 3.2 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DSBA PF01323.20 ORX74377.1 - 3.2e-36 124.9 0.0 3.7e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 ORX74377.1 - 0.00068 19.6 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin_4 PF13462.6 ORX74377.1 - 0.0023 18.1 0.0 0.0042 17.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.6 ORX74377.1 - 0.0026 17.5 0.0 0.0045 16.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AP_endonuc_2 PF01261.24 ORX74377.1 - 0.052 13.0 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel ApoA-II PF04711.13 ORX74377.1 - 0.079 13.1 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) MWFE PF15879.5 ORX74380.1 - 0.13 12.4 0.2 0.38 11.0 0.2 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase MWFE subunit Rsm22 PF09243.10 ORX74381.1 - 4.2e-71 239.4 0.0 5e-71 239.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_25 PF13649.6 ORX74381.1 - 2.4e-06 28.1 0.0 7.8e-06 26.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX74381.1 - 0.00021 21.1 0.0 0.002 17.9 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74381.1 - 0.0003 21.5 0.0 0.00098 19.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX74381.1 - 0.016 15.1 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ORX74381.1 - 0.032 14.9 0.0 0.087 13.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ORX74381.1 - 0.049 13.0 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCI PF01399.27 ORX74382.1 - 9e-17 61.5 0.0 5.8e-16 58.9 0.0 2.4 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 ORX74382.1 - 5.2e-16 58.4 2.7 2.9e-15 56.0 1.9 2.5 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN5 C-terminal domain HOIP-UBA PF16678.5 ORX74382.1 - 0.007 16.4 0.5 0.19 11.7 0.4 2.3 1 1 1 2 2 2 1 HOIP UBA domain pair VBS PF08913.10 ORX74382.1 - 0.013 15.9 0.2 0.034 14.6 0.2 1.7 1 0 0 1 1 1 0 Vinculin Binding Site FAM83 PF07894.12 ORX74382.1 - 0.04 13.5 0.4 0.32 10.5 0.5 2.0 2 0 0 2 2 2 0 FAM83 A-H Acetyltransf_10 PF13673.7 ORX74383.1 - 3.6e-18 65.7 0.0 3.9e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX74383.1 - 5.2e-14 52.4 0.0 8.2e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX74383.1 - 5.3e-12 46.0 0.0 6.6e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 ORX74383.1 - 9e-08 32.8 0.1 7.1e-07 29.9 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX74383.1 - 5.2e-05 23.3 0.2 0.0011 19.1 0.2 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX74383.1 - 0.00017 21.7 0.0 0.00034 20.7 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ORX74383.1 - 0.02 14.8 0.0 0.038 14.0 0.0 1.5 1 1 0 1 1 1 0 FR47-like protein Autoind_synth PF00765.17 ORX74383.1 - 0.075 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Autoinducer synthase Acetyltransf_15 PF17013.5 ORX74383.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_3 PF13302.7 ORX74383.1 - 0.18 12.4 0.0 0.21 12.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Cyclin PF08613.11 ORX74384.1 - 1.9e-34 119.4 0.1 2.8e-34 118.8 0.1 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX74384.1 - 9.2e-05 22.2 0.1 0.00014 21.6 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain RCDG1 PF15725.5 ORX74384.1 - 6.7 7.2 8.5 0.49 10.8 0.8 2.4 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein Cofilin_ADF PF00241.20 ORX74385.1 - 3.2e-27 94.8 0.0 2.9e-14 52.9 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein CAS_CSE1 PF03378.15 ORX74385.1 - 0.26 9.8 0.0 0.41 9.1 0.0 1.2 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Proteasome PF00227.26 ORX74386.1 - 1.5e-59 200.7 0.0 1.8e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX74386.1 - 6.2e-14 51.3 0.0 1.3e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PTR2 PF00854.21 ORX74387.1 - 7.4e-41 140.3 1.6 9.2e-41 140.0 0.2 1.6 2 0 0 2 2 2 1 POT family PTR2 PF00854.21 ORX74388.1 - 4.1e-43 147.7 2.6 7.9e-42 143.5 2.5 2.2 1 1 0 1 1 1 1 POT family DUF3852 PF12963.7 ORX74388.1 - 0.52 10.7 3.7 0.91 9.9 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3852) AMP-binding PF00501.28 ORX74390.1 - 1.9e-20 72.9 0.0 2.2e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding PF00501.28 ORX74391.1 - 1.3e-74 251.3 0.1 9e-74 248.6 0.1 1.9 1 1 0 1 1 1 1 AMP-binding enzyme DUF505 PF04458.12 ORX74391.1 - 0.047 12.1 0.1 3.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF505) AMP-binding_C PF13193.6 ORX74391.1 - 0.097 13.7 0.1 0.95 10.5 0.1 2.5 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain AA_permease_2 PF13520.6 ORX74392.1 - 2.5e-55 188.0 38.2 3.8e-55 187.5 38.2 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX74392.1 - 4.9e-24 84.8 35.1 7.3e-24 84.2 35.1 1.1 1 0 0 1 1 1 1 Amino acid permease Rsa3 PF14615.6 ORX74392.1 - 2.4e-12 46.2 0.1 5e-12 45.2 0.1 1.6 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Macoilin PF09726.9 ORX74392.1 - 0.38 9.3 20.6 0.59 8.6 20.6 1.2 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 ORX74392.1 - 1.6 8.0 13.8 2.3 7.5 13.8 1.1 1 0 0 1 1 1 0 FAM76 protein SPX PF03105.19 ORX74392.1 - 2.7 7.8 25.4 4.1 7.2 25.4 1.2 1 0 0 1 1 1 0 SPX domain SDA1 PF05285.12 ORX74392.1 - 4 6.8 24.5 5.9 6.2 24.5 1.2 1 0 0 1 1 1 0 SDA1 TFIIF_alpha PF05793.12 ORX74392.1 - 4.1 5.9 28.2 6 5.3 28.2 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 ORX74392.1 - 8.1 5.7 30.6 12 5.1 30.6 1.1 1 0 0 1 1 1 0 BUD22 Apt1 PF10351.9 ORX74392.1 - 9.9 4.9 22.2 16 4.2 22.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S8 PF00082.22 ORX74393.1 - 4.8e-36 124.5 0.2 3.2e-35 121.9 0.2 1.9 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 ORX74393.1 - 1.5e-26 92.2 0.5 3e-26 91.2 0.5 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF2914 PF11141.8 ORX74393.1 - 0.096 12.5 0.4 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2914) RasGAP PF00616.19 ORX74394.1 - 7.7e-19 68.2 0.0 7.3e-16 58.5 0.0 2.2 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Arrestin_C PF02752.22 ORX74395.1 - 0.011 16.1 0.0 0.064 13.7 0.0 2.0 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX74395.1 - 0.11 12.6 0.0 5.5 7.0 0.0 2.3 1 1 1 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Methyltransf_31 PF13847.6 ORX74397.1 - 2.3e-15 56.7 0.0 3.3e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX74397.1 - 5.7e-10 39.8 0.0 8.3e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX74397.1 - 5.3e-06 27.0 0.0 8.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX74397.1 - 9.1e-05 22.3 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ORX74397.1 - 0.00079 18.8 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 ORX74397.1 - 0.0042 16.4 0.0 0.0077 15.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ORX74397.1 - 0.0054 16.6 0.0 0.0064 16.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74397.1 - 0.0088 16.8 0.0 0.014 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain YqfQ PF14181.6 ORX74397.1 - 0.14 12.3 0.6 0.26 11.5 0.6 1.3 1 0 0 1 1 1 0 YqfQ-like protein MTS PF05175.14 ORX74397.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CLTH PF10607.9 ORX74400.1 - 4.4e-15 55.9 0.0 3.4e-14 53.0 0.0 2.0 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.15 ORX74401.1 - 7.2e-21 74.2 0.6 1.3e-20 73.4 0.6 1.4 1 0 0 1 1 1 1 U-box domain AAA_2 PF07724.14 ORX74402.1 - 5.7e-46 156.7 0.0 1.6e-45 155.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 ORX74402.1 - 3.7e-24 84.6 0.1 3.7e-24 84.6 0.1 2.2 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_lid_9 PF17871.1 ORX74402.1 - 2.3e-15 56.4 4.7 5.6e-15 55.1 2.8 2.5 1 1 1 2 2 2 1 AAA lid domain AAA_5 PF07728.14 ORX74402.1 - 1.3e-10 41.4 0.0 4.7e-10 39.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ORX74402.1 - 3.2e-09 37.3 0.0 6.7e-08 33.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX74402.1 - 6.2e-07 29.3 0.0 1.5e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_23 PF13476.6 ORX74402.1 - 5.9e-05 23.7 1.7 0.13 12.8 0.6 3.0 3 0 0 3 3 3 2 AAA domain DNA_pol3_delta2 PF13177.6 ORX74402.1 - 0.0018 18.1 0.0 3 7.6 0.0 2.6 2 0 0 2 2 2 2 DNA polymerase III, delta subunit AAA_22 PF13401.6 ORX74402.1 - 0.0032 17.7 0.6 0.088 13.1 0.1 3.3 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX74402.1 - 0.0039 16.5 0.0 0.0088 15.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.27 ORX74402.1 - 0.0071 16.9 0.4 0.12 12.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 ORX74402.1 - 0.028 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX74402.1 - 0.034 14.5 6.4 0.16 12.4 0.0 4.3 6 0 0 6 6 6 0 AAA ATPase domain AAA_28 PF13521.6 ORX74402.1 - 0.16 12.2 1.0 4.7 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain PP28 PF10252.9 ORX74402.1 - 8.1 7.0 9.7 2 8.9 5.8 2.0 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 USP7_ICP0_bdg PF12436.8 ORX74403.1 - 5e-48 163.5 0.0 1.2e-47 162.3 0.0 1.7 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 ORX74403.1 - 9.2e-43 146.6 0.0 2.5e-41 141.9 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ORX74403.1 - 1.4e-23 83.7 0.0 1.6e-22 80.3 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH_1 PF13423.6 ORX74403.1 - 4.2e-20 72.6 0.0 6.8e-10 39.0 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Tmemb_14 PF03647.13 ORX74403.1 - 1.3e-10 41.8 0.1 2.5e-10 41.0 0.1 1.4 1 0 0 1 1 1 1 Transmembrane proteins 14C FancD2 PF14631.6 ORX74404.1 - 1.3e-96 324.4 8.7 1.8e-53 181.5 0.1 5.5 4 1 1 5 5 5 5 Fanconi anaemia protein FancD2 nuclease SUZ PF12752.7 ORX74404.1 - 5.9e-06 26.9 8.0 1.6e-05 25.6 6.2 2.6 2 0 0 2 2 2 1 SUZ domain FANCI_S2 PF14676.6 ORX74404.1 - 0.0066 16.8 0.5 0.33 11.3 0.0 3.2 4 0 0 4 4 4 1 FANCI solenoid 2 CENP-C_C PF11699.8 ORX74405.1 - 2.2e-16 59.8 0.1 3.8e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 ORX74405.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Cupin domain MannoseP_isomer PF01050.18 ORX74405.1 - 0.05 13.5 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase DEAD PF00270.29 ORX74406.1 - 7.8e-35 120.2 0.1 1.4e-34 119.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX74406.1 - 1.2e-18 67.5 0.0 1.3e-14 54.5 0.0 3.9 4 0 0 4 4 4 2 Helicase conserved C-terminal domain ResIII PF04851.15 ORX74406.1 - 5.1e-08 33.1 0.0 1.2e-07 31.8 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX74406.1 - 6.5e-05 23.2 1.0 0.00041 20.6 0.0 2.8 2 2 2 4 4 4 1 AAA domain SbcCD_C PF13558.6 ORX74406.1 - 0.086 13.1 0.7 11 6.4 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF2514 PF10721.9 ORX74406.1 - 0.24 11.4 10.3 0.82 9.7 10.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) PT PF04886.12 ORX74406.1 - 0.4 10.3 2.5 0.81 9.3 2.5 1.5 1 0 0 1 1 1 0 PT repeat FMN_dh PF01070.18 ORX74407.1 - 1e-138 462.1 2.4 1.2e-138 462.0 2.4 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ORX74407.1 - 1.3e-07 31.0 3.1 4.5e-07 29.2 2.2 2.2 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ORX74407.1 - 2.5e-06 27.1 3.4 4.4e-06 26.3 3.1 1.5 1 1 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 ORX74407.1 - 1.6e-05 24.3 1.1 0.13 11.5 0.0 3.1 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 ORX74407.1 - 4.8e-05 22.7 0.3 8.8e-05 21.8 0.3 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 ORX74407.1 - 0.00037 20.0 0.7 0.016 14.6 0.0 2.5 1 1 1 2 2 2 1 Histidine biosynthesis protein G3P_antiterm PF04309.12 ORX74407.1 - 0.0074 15.7 0.1 1.8 8.0 0.1 2.5 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator DHO_dh PF01180.21 ORX74407.1 - 0.0087 15.3 0.1 0.088 12.0 0.1 2.1 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase DHDPS PF00701.22 ORX74407.1 - 0.0099 14.6 0.1 0.16 10.6 0.0 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate synthetase family Dus PF01207.17 ORX74407.1 - 0.011 14.9 0.1 0.079 12.0 0.2 2.1 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 ORX74407.1 - 0.073 12.4 0.6 0.22 10.8 0.2 2.0 2 0 0 2 2 2 0 Thiamine monophosphate synthase ABC_membrane PF00664.23 ORX74408.1 - 1.3e-61 208.6 1.3 2e-61 208.1 1.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX74408.1 - 7.9e-34 117.1 0.0 1.3e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 ORX74408.1 - 0.0029 16.9 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 ORX74408.1 - 0.011 16.1 0.0 0.032 14.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ORX74408.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX74408.1 - 0.025 15.0 0.0 0.077 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ORX74408.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 ORX74408.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 ORX74408.1 - 0.24 11.1 0.0 0.37 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_membrane PF00664.23 ORX74409.1 - 3.4e-20 72.8 9.5 4.5e-08 33.1 1.5 3.2 2 1 1 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ORX74409.1 - 2.2e-11 44.4 0.0 5.7e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Rad17 PF03215.15 ORX74409.1 - 5.9e-06 26.3 0.0 0.019 14.9 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain Aminotran_3 PF00202.21 ORX74411.1 - 1.3e-104 350.1 0.0 1.5e-104 349.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ORX74411.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.6 1 1 0 1 1 1 0 Aminotransferase class I and II ADK PF00406.22 ORX74412.1 - 1.9e-58 196.9 0.0 2.2e-58 196.7 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX74412.1 - 6.6e-23 81.6 0.0 1.1e-22 80.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ORX74412.1 - 4.5e-17 61.7 0.0 1.3e-16 60.3 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ORX74412.1 - 2.4e-05 24.5 0.0 4.8e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX74412.1 - 0.00024 21.7 0.0 0.00034 21.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 ORX74412.1 - 0.0055 16.5 0.0 0.0077 16.0 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase SRP54 PF00448.22 ORX74412.1 - 0.012 15.3 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 ORX74412.1 - 0.025 14.3 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Hydin_ADK PF17213.3 ORX74412.1 - 0.058 13.7 0.2 0.24 11.7 0.1 1.9 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain AAA PF00004.29 ORX74412.1 - 0.098 13.1 0.1 0.14 12.5 0.1 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mid2 PF04478.12 ORX74413.1 - 0.16 11.8 0.3 0.2 11.5 0.3 1.1 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SKG6 PF08693.10 ORX74413.1 - 0.32 10.5 5.1 0.86 9.1 5.1 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LRR_9 PF14580.6 ORX74414.1 - 4.4e-59 198.9 1.0 6e-59 198.5 1.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 ORX74414.1 - 2.2e-10 40.1 11.9 2.1e-09 37.0 1.7 3.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ORX74414.1 - 7.8e-09 35.7 15.6 0.00046 20.5 0.4 3.8 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX74414.1 - 0.013 15.5 8.3 28 5.1 0.1 5.6 6 0 0 6 6 6 0 Leucine Rich repeat DUF4168 PF13767.6 ORX74414.1 - 0.037 15.2 2.0 0.077 14.2 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) LRR_1 PF00560.33 ORX74414.1 - 1.7 9.5 14.6 72 4.5 0.1 5.5 4 2 1 5 5 5 0 Leucine Rich Repeat NADH-u_ox-rdase PF10785.9 ORX74415.1 - 1.6e-17 63.9 0.0 2.4e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 ORX74415.1 - 1.9e-08 34.2 0.0 3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Ubiq_cyt_C_chap PF03981.12 ORX74416.1 - 1e-30 106.7 0.0 1.4e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone CaiF_GrlA PF07180.11 ORX74416.1 - 0.058 13.4 0.1 0.096 12.7 0.1 1.4 1 0 0 1 1 1 0 CaiF/GrlA transcriptional regulator TIC20 PF16166.5 ORX74416.1 - 0.063 13.1 0.8 0.093 12.5 0.8 1.2 1 0 0 1 1 1 0 Chloroplast import apparatus Tic20-like Cytokin_check_N PF10407.9 ORX74417.1 - 7.8e-12 45.0 0.0 1.3e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Cdc14 phosphatase binding protein N-terminus ABC_membrane PF00664.23 ORX74418.1 - 6.8e-95 317.8 14.2 2.5e-47 161.8 1.4 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ORX74418.1 - 8.1e-68 227.2 0.0 2.4e-33 115.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX74418.1 - 4.3e-16 59.0 0.1 4.6e-05 23.0 0.0 4.1 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA PF00004.29 ORX74418.1 - 1.2e-07 32.2 0.3 0.59 10.6 0.0 4.3 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 ORX74418.1 - 1.4e-07 30.7 0.5 0.01 14.7 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 ORX74418.1 - 3e-07 30.8 1.1 0.046 14.0 0.0 3.9 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX74418.1 - 3.6e-07 29.8 1.9 0.0082 15.9 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 ORX74418.1 - 7.1e-07 29.1 0.2 0.0083 15.9 0.1 3.3 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 ORX74418.1 - 1.4e-06 27.7 0.8 0.012 14.9 0.0 3.1 3 0 0 3 3 3 2 Zeta toxin AAA_16 PF13191.6 ORX74418.1 - 5.6e-06 26.8 2.9 0.13 12.6 0.7 3.3 3 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX74418.1 - 1.8e-05 24.7 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase SbcCD_C PF13558.6 ORX74418.1 - 0.00018 21.7 2.0 0.77 10.0 0.1 3.9 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 ORX74418.1 - 0.00021 20.6 0.0 0.54 9.4 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.14 ORX74418.1 - 0.00057 19.9 1.0 3.5 7.6 0.0 3.8 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX74418.1 - 0.00065 19.3 0.1 0.88 9.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 ORX74418.1 - 0.0012 18.6 0.1 1.3 8.8 0.0 2.6 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 ORX74418.1 - 0.0031 18.0 0.3 0.59 10.7 0.2 3.1 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ORX74418.1 - 0.0046 16.8 0.1 0.23 11.2 0.0 3.3 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ORX74418.1 - 0.005 16.4 0.5 3.1 7.3 0.1 3.6 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.15 ORX74418.1 - 0.0095 15.9 1.2 10 6.0 0.1 3.4 2 1 1 3 3 3 0 NTPase AAA_15 PF13175.6 ORX74418.1 - 0.011 15.5 0.0 0.9 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX74418.1 - 0.017 15.2 0.2 11 6.1 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ORX74418.1 - 0.017 15.6 1.1 2.1 8.8 0.4 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 ORX74418.1 - 0.018 15.0 0.0 6.9 6.5 0.0 3.2 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA_28 PF13521.6 ORX74418.1 - 0.018 15.3 0.3 37 4.5 0.3 3.5 2 1 1 3 3 3 0 AAA domain DUF815 PF05673.13 ORX74418.1 - 0.021 14.0 0.1 1 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ORX74418.1 - 0.032 14.6 0.1 9.8 6.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase PRK PF00485.18 ORX74418.1 - 0.033 13.9 0.0 6.4 6.5 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 ORX74418.1 - 0.037 14.2 0.0 2.1 8.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ORX74418.1 - 0.044 14.0 0.3 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 ORX74418.1 - 0.045 13.7 0.0 11 5.9 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain NB-ARC PF00931.22 ORX74418.1 - 0.088 12.0 0.2 7.3 5.7 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 ORX74418.1 - 0.11 12.3 0.1 5.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF3852 PF12963.7 ORX74418.1 - 0.14 12.5 3.7 0.26 11.6 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3852) NACHT PF05729.12 ORX74418.1 - 0.61 10.0 2.3 24 4.8 0.2 2.5 2 0 0 2 2 2 0 NACHT domain CDT1_C PF16679.5 ORX74419.1 - 0.083 13.3 0.0 0.1 13.0 0.0 1.1 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain PQ-loop PF04193.14 ORX74421.1 - 3.8e-36 122.6 14.5 2.3e-18 65.7 2.8 3.0 3 0 0 3 3 3 2 PQ loop repeat TMEM101 PF15111.6 ORX74421.1 - 0.01 15.4 0.4 0.016 14.8 0.4 1.3 1 0 0 1 1 1 0 TMEM101 protein family MtN3_slv PF03083.16 ORX74421.1 - 0.037 14.1 0.9 0.11 12.5 0.9 1.9 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange Mito_carr PF00153.27 ORX74422.1 - 4.7e-30 103.4 5.7 1.9e-16 59.8 0.0 5.4 5 0 0 5 5 5 4 Mitochondrial carrier protein Glyco_hydro_46 PF01374.18 ORX74423.1 - 3.2e-27 95.5 1.9 5.1e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 46 FAM217 PF15344.6 ORX74424.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 FAM217 family AAA_12 PF13087.6 ORX74425.1 - 1.6e-56 191.1 0.0 1.8e-55 187.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ORX74425.1 - 2e-42 145.8 0.3 1.3e-41 143.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX74425.1 - 4.6e-14 52.6 3.1 5.5e-13 49.1 2.5 2.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX74425.1 - 1.7e-09 38.1 0.2 1e-08 35.6 0.0 2.3 2 2 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ORX74425.1 - 1.9e-05 24.5 0.2 0.15 11.8 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 ORX74425.1 - 5.5e-05 23.6 0.6 0.00029 21.3 0.7 2.2 1 1 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.14 ORX74425.1 - 0.00062 19.7 0.1 0.0048 16.8 0.1 2.5 2 1 0 2 2 2 1 Helicase DUF2075 PF09848.9 ORX74425.1 - 0.0012 18.2 0.1 0.023 13.9 0.1 2.4 1 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ORX74425.1 - 0.0023 18.2 0.1 0.019 15.3 0.1 2.6 1 1 0 1 1 1 1 AAA domain Zot PF05707.12 ORX74425.1 - 0.0027 17.4 0.0 0.18 11.4 0.0 2.3 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_33 PF13671.6 ORX74425.1 - 0.0035 17.5 0.0 0.016 15.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain ResIII PF04851.15 ORX74425.1 - 0.0056 16.7 0.0 0.014 15.4 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX74425.1 - 0.0059 16.1 0.1 0.02 14.3 0.1 1.9 1 1 0 1 1 1 1 PhoH-like protein AAA PF00004.29 ORX74425.1 - 0.0066 16.9 0.0 0.017 15.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ORX74425.1 - 0.012 14.7 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 ORX74425.1 - 0.016 14.8 0.0 0.064 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 ORX74425.1 - 0.027 14.3 0.0 0.24 11.1 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase UvrD-helicase PF00580.21 ORX74425.1 - 0.027 14.0 0.0 0.052 13.0 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_6 PF12774.7 ORX74425.1 - 0.044 12.8 0.0 0.076 12.0 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region UvrD_C_2 PF13538.6 ORX74425.1 - 0.051 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_24 PF13479.6 ORX74425.1 - 0.052 13.3 0.0 0.21 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain ParA PF10609.9 ORX74425.1 - 0.058 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Flavi_DEAD PF07652.14 ORX74425.1 - 0.098 12.6 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.12 ORX74425.1 - 0.098 12.6 0.0 0.98 9.3 0.0 2.5 3 0 0 3 3 3 0 NACHT domain AAA_7 PF12775.7 ORX74425.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase PF00069.25 ORX74426.1 - 1.2e-35 123.2 0.1 2.2e-25 89.5 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74426.1 - 4.6e-16 58.9 0.1 8.3e-14 51.5 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ORX74426.1 - 3.7e-06 27.1 0.3 0.00049 20.1 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX74426.1 - 1.4e-05 24.2 0.0 2.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ORX74426.1 - 0.026 14.1 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Se-cys_synth_N PF12390.8 ORX74426.1 - 0.084 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Selenocysteine synthase N terminal Seadorna_VP7 PF07387.11 ORX74426.1 - 0.095 11.7 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RAB3GAP2_N PF14655.6 ORX74427.1 - 2.1e-23 83.3 0.0 3.5e-13 49.6 0.0 3.4 2 2 1 3 3 3 3 Rab3 GTPase-activating protein regulatory subunit N-terminus YadA_anchor PF03895.15 ORX74427.1 - 2.1 8.5 5.4 2.1 8.5 0.1 3.0 3 0 0 3 3 3 0 YadA-like membrane anchor domain Glyco_transf_25 PF01755.17 ORX74428.1 - 2.6e-10 40.5 1.0 4.3e-08 33.3 0.9 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Pox_P35 PF03213.14 ORX74428.1 - 0.01 15.1 0.0 0.015 14.5 0.0 1.3 1 1 0 1 1 1 0 Poxvirus P35 protein TIP39 PF14980.6 ORX74428.1 - 0.067 13.1 0.1 2.4 8.1 0.1 2.5 2 0 0 2 2 2 0 TIP39 peptide Glyco_transf_54 PF04666.13 ORX74428.1 - 0.18 10.6 0.1 0.26 10.1 0.1 1.2 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Pkinase PF00069.25 ORX74429.1 - 4.4e-40 137.7 0.0 4.3e-27 95.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74429.1 - 3.5e-20 72.4 0.1 3.2e-16 59.4 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 ORX74429.1 - 0.00026 21.0 0.7 0.00049 20.1 0.1 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX74429.1 - 0.00049 19.5 0.1 0.035 13.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX74429.1 - 0.0047 15.9 0.0 0.0069 15.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX74429.1 - 0.12 11.8 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2469 PF10611.9 ORX74429.1 - 0.12 13.0 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2469) TSC22 PF01166.18 ORX74431.1 - 1.2e-05 25.5 15.4 0.098 13.0 0.6 5.2 4 0 0 4 4 4 3 TSC-22/dip/bun family APG6_N PF17675.1 ORX74431.1 - 0.0027 18.3 7.6 0.0027 18.3 7.6 5.0 4 1 1 5 5 5 3 Apg6 coiled-coil region GAS PF13851.6 ORX74431.1 - 0.0039 16.6 8.8 0.0039 16.6 8.8 4.6 3 2 0 4 4 4 3 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 ORX74431.1 - 0.012 15.9 11.2 0.012 15.9 11.2 4.5 4 1 0 4 4 4 0 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 ORX74431.1 - 0.012 15.4 9.5 0.012 15.4 9.5 4.7 4 1 0 4 4 4 0 Coiled-coil region of CCDC155 or KASH ABC_tran_CTD PF16326.5 ORX74431.1 - 0.02 15.1 1.4 0.02 15.1 1.4 5.7 5 2 1 6 6 6 0 ABC transporter C-terminal domain DUF4600 PF15372.6 ORX74431.1 - 0.022 15.2 2.3 0.022 15.2 2.3 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4600) TMCO5 PF14992.6 ORX74431.1 - 0.035 13.7 0.3 0.035 13.7 0.3 3.4 3 0 0 3 3 3 0 TMCO5 family FapA PF03961.13 ORX74431.1 - 0.18 10.4 13.3 0.46 9.0 0.6 3.1 3 1 0 3 3 3 0 Flagellar Assembly Protein A Rootletin PF15035.6 ORX74431.1 - 0.29 11.2 41.5 0.97 9.4 0.7 4.7 3 2 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion CSN5_C PF18323.1 ORX74431.1 - 0.55 11.2 0.1 0.55 11.2 0.1 4.5 4 2 1 5 5 5 0 Cop9 signalosome subunit 5 C-terminal domain Jnk-SapK_ap_N PF09744.9 ORX74431.1 - 0.55 10.4 41.7 0.91 9.7 0.4 5.4 4 1 1 5 5 5 0 JNK_SAPK-associated protein-1 Atg14 PF10186.9 ORX74431.1 - 0.63 9.1 30.9 0.018 14.2 9.5 2.6 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 ORX74431.1 - 1.1 9.8 6.6 1.6 9.2 0.2 3.8 4 1 0 4 4 3 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 ORX74431.1 - 1.2 9.3 45.9 16 5.6 0.8 4.6 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 ORX74431.1 - 1.3 9.1 45.1 0.29 11.2 4.5 5.3 4 1 1 5 5 5 0 Afadin- and alpha -actinin-Binding BLOC1_2 PF10046.9 ORX74431.1 - 1.6 9.1 20.2 2.4 8.5 0.1 4.8 3 2 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lectin_N PF03954.14 ORX74431.1 - 2.5 7.9 10.7 2.6 7.8 0.2 3.7 3 2 1 4 4 4 0 Hepatic lectin, N-terminal domain Csm1_N PF18504.1 ORX74431.1 - 3.6 8.0 37.7 1 9.8 1.5 5.8 6 1 0 6 6 6 0 Csm1 N-terminal domain bZIP_1 PF00170.21 ORX74431.1 - 5.2 7.3 31.8 0.23 11.6 0.8 5.7 5 1 1 6 6 6 0 bZIP transcription factor Spc24 PF08286.11 ORX74431.1 - 5.7 7.2 32.4 2.5 8.4 1.0 5.5 3 2 1 4 4 4 0 Spc24 subunit of Ndc80 Cnn_1N PF07989.11 ORX74431.1 - 9.9 6.4 38.1 0.057 13.6 2.3 6.0 5 1 1 6 6 6 0 Centrosomin N-terminal motif 1 Cation_ATPase_C PF00689.21 ORX74432.1 - 1.2e-32 113.1 1.1 1.2e-32 113.1 1.1 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX74432.1 - 1.5e-15 58.0 0.2 5e-14 53.1 0.2 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX74432.1 - 6.1e-14 51.9 0.0 1.7e-13 50.5 0.0 1.8 1 1 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ORX74432.1 - 3.9e-10 39.6 0.4 5.7e-08 32.5 0.1 3.7 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 ORX74432.1 - 8.3e-08 31.8 0.1 5.5e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX74432.1 - 0.00095 19.0 1.0 0.0019 18.0 1.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Usp PF00582.26 ORX74433.1 - 4.1e-10 40.3 0.0 5.4e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family HAD_SAK_1 PF10307.9 ORX74434.1 - 6.1e-26 91.5 0.1 1.1e-25 90.7 0.1 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins S6PP PF05116.13 ORX74434.1 - 0.057 12.9 0.1 0.083 12.4 0.1 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 ORX74434.1 - 0.13 11.9 0.0 0.46 10.2 0.0 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase V-ATPase_G_2 PF16999.5 ORX74435.1 - 0.0013 19.2 0.8 0.0013 19.2 0.8 1.6 1 1 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF5324 PF17258.2 ORX74435.1 - 0.011 15.5 3.2 0.013 15.2 3.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5324) MCPVI PF02993.14 ORX74435.1 - 0.018 14.9 0.3 0.021 14.6 0.3 1.1 1 0 0 1 1 1 0 Minor capsid protein VI CRCB PF02537.15 ORX74436.1 - 3.1e-18 65.9 10.0 7.4e-17 61.5 2.1 2.4 2 1 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) DUF5368 PF17336.2 ORX74437.1 - 0.048 13.8 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5368) DiS_P_DiS PF06750.13 ORX74438.1 - 0.18 11.9 0.3 0.18 11.9 0.3 2.6 3 1 0 3 3 3 0 Bacterial Peptidase A24 N-terminal domain Enolase_C PF00113.22 ORX74439.1 - 2.3e-157 522.8 0.2 3e-157 522.4 0.2 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ORX74439.1 - 9.2e-56 187.6 0.1 1.6e-55 186.8 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ORX74439.1 - 1.6e-08 34.4 0.0 2.2e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ORX74439.1 - 3.9e-05 22.9 0.2 0.0001 21.5 0.1 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Ribosomal_S27e PF01667.17 ORX74442.1 - 2.8e-29 100.6 4.6 3.4e-29 100.3 4.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-CSL PF05207.13 ORX74442.1 - 0.019 14.7 1.3 0.044 13.5 1.3 1.6 1 1 0 1 1 1 0 CSL zinc finger Prok-RING_1 PF14446.6 ORX74442.1 - 0.02 14.8 3.4 0.032 14.2 3.4 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 IBR PF01485.21 ORX74442.1 - 0.047 13.9 1.4 0.057 13.6 1.4 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 ORX74442.1 - 0.35 10.4 4.4 0.54 9.8 4.4 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 ORX74442.1 - 0.5 10.3 3.8 9.6 6.2 0.2 2.6 3 0 0 3 3 3 0 zinc-ribbon domain Eapp_C PF10238.9 ORX74442.1 - 3.6 7.7 5.5 20 5.3 2.0 2.0 1 1 1 2 2 2 0 E2F-associated phosphoprotein MAS20 PF02064.15 ORX74443.1 - 1.8e-37 128.3 3.6 1.8e-37 128.3 3.6 4.2 4 0 0 4 4 4 1 MAS20 protein import receptor SET PF00856.28 ORX74443.1 - 2.5e-10 41.0 13.8 7.9e-10 39.4 3.1 3.8 2 2 0 2 2 2 1 SET domain zf-MYND PF01753.18 ORX74443.1 - 6.1e-05 23.0 5.2 6.1e-05 23.0 5.2 2.2 3 0 0 3 3 3 1 MYND finger Ecl1 PF12855.7 ORX74443.1 - 0.37 11.9 2.8 1 10.5 1.0 2.4 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins ATP-cone PF03477.16 ORX74443.1 - 2.2 8.9 14.3 0.19 12.3 8.1 2.3 2 0 0 2 2 2 0 ATP cone domain zn-ribbon_14 PF16503.5 ORX74444.1 - 4.5e-17 61.2 1.3 4.5e-17 61.2 1.3 3.7 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 ORX74444.1 - 8.2e-17 61.5 0.0 1.4e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 PP-loop family TF_Zn_Ribbon PF08271.12 ORX74444.1 - 0.015 14.8 0.5 0.015 14.8 0.5 3.8 4 1 1 5 5 5 0 TFIIB zinc-binding ThiI PF02568.14 ORX74444.1 - 0.15 11.6 0.0 0.64 9.6 0.0 1.9 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) SLD5_C PF16922.5 ORX74446.1 - 0.00036 20.7 0.1 0.00077 19.6 0.1 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 ORX74446.1 - 0.0082 16.6 0.1 0.015 15.8 0.1 1.6 1 0 0 1 1 1 1 GINS complex protein P16-Arc PF04699.14 ORX74447.1 - 3.4e-44 150.9 0.1 3.7e-44 150.8 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 ORX74447.1 - 0.0032 17.7 0.0 0.01 16.1 0.0 1.7 2 0 0 2 2 2 1 Dip2/Utp12 Family DUF2605 PF10792.9 ORX74447.1 - 0.075 13.0 0.7 9.6 6.2 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2605) HsbA PF12296.8 ORX74447.1 - 0.25 11.8 6.0 6.7 7.2 0.2 2.2 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Rhodanese PF00581.20 ORX74449.1 - 1.5e-09 38.4 0.0 1.7e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain LRR_6 PF13516.6 ORX74450.1 - 0.15 12.2 2.0 54 4.2 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Herpes_US12 PF05363.12 ORX74451.1 - 0.06 14.1 0.5 0.46 11.2 0.3 2.3 2 0 0 2 2 2 0 Herpesvirus US12 family FUSC_2 PF13515.6 ORX74452.1 - 2.6e-17 63.1 7.6 2.6e-17 63.1 7.6 2.1 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 ORX74452.1 - 2.2e-12 46.4 20.3 4.4e-11 42.1 10.0 3.2 4 0 0 4 4 4 2 Fusaric acid resistance protein family ALMT PF11744.8 ORX74452.1 - 5.9e-10 38.6 11.7 1.7e-06 27.1 6.7 2.5 3 0 0 3 3 3 2 Aluminium activated malate transporter ArAE_2 PF10334.9 ORX74452.1 - 4.4e-09 36.5 1.0 0.012 15.5 0.0 3.3 3 0 0 3 3 3 3 Aromatic acid exporter family member 2 EXOSC1 PF10447.9 ORX74453.1 - 1.5e-16 61.0 2.7 2.4e-13 50.6 0.3 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 Thioredoxin PF00085.20 ORX74454.1 - 0.0011 19.0 0.0 0.0035 17.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin FGGY_C PF02782.16 ORX74455.1 - 3.6e-33 115.0 0.0 5.8e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ORX74455.1 - 2.7e-15 56.6 0.0 3.1e-14 53.2 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Diphthami_syn_2 PF01902.17 ORX74456.1 - 6.3e-41 140.3 0.0 1.1e-40 139.5 0.0 1.3 1 1 0 1 1 1 1 Diphthamide synthase tRNA_Me_trans PF03054.16 ORX74456.1 - 0.02 13.7 0.0 0.047 12.5 0.0 1.6 2 0 0 2 2 2 0 tRNA methyl transferase QueC PF06508.13 ORX74456.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Peptidase_S9 PF00326.21 ORX74458.1 - 3.1e-57 193.5 0.1 9.6e-57 191.9 0.1 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family PD40 PF07676.12 ORX74458.1 - 3e-06 27.0 0.0 0.044 13.7 0.1 3.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat AXE1 PF05448.12 ORX74458.1 - 0.0076 15.0 0.0 0.097 11.3 0.0 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 ORX74458.1 - 0.017 14.8 0.5 0.41 10.2 0.1 2.4 2 1 0 2 2 2 0 Putative esterase Peptidase_S9_N PF02897.15 ORX74458.1 - 0.023 13.5 1.7 4.1 6.1 0.0 2.9 2 1 1 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Hydrolase_4 PF12146.8 ORX74458.1 - 0.034 13.4 0.0 3.2 7.0 0.1 2.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Aldedh PF00171.22 ORX74459.1 - 1.1e-79 268.2 0.0 1.3e-79 267.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 ORX74460.1 - 3.4e-85 286.3 0.0 4.2e-85 286.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 ORX74461.1 - 7e-66 222.6 0.0 4.2e-39 134.4 0.1 2.9 1 1 1 2 2 2 2 Aldehyde dehydrogenase family HMG_box PF00505.19 ORX74469.1 - 4.3e-14 52.7 3.4 8.3e-14 51.8 3.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX74469.1 - 1.8e-10 41.3 3.9 5e-10 39.8 3.9 1.8 1 0 0 1 1 1 1 HMG-box domain DUF2582 PF10771.9 ORX74469.1 - 0.012 15.7 0.3 0.023 14.8 0.3 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix domain (DUF2582) SUIM_assoc PF16619.5 ORX74469.1 - 0.021 14.9 15.5 0.24 11.5 0.1 3.7 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 HMG_box_5 PF14887.6 ORX74469.1 - 0.025 14.5 0.4 0.056 13.4 0.4 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box 5 Mucin PF01456.17 ORX74470.1 - 1.4 8.9 15.1 3.9 7.5 15.1 1.8 1 1 0 1 1 1 0 Mucin-like glycoprotein HAP1_N PF04849.13 ORX74471.1 - 8.5e-07 28.5 2.1 8.5e-07 28.5 2.1 3.4 2 1 0 3 3 3 1 HAP1 N-terminal conserved region Sirohm_synth_C PF14823.6 ORX74471.1 - 0.054 13.1 7.6 0.075 12.7 0.1 3.9 4 0 0 4 4 4 0 Sirohaem biosynthesis protein C-terminal dUTPase PF00692.19 ORX74472.1 - 9.4e-21 73.8 0.1 2.1e-18 66.2 0.1 2.1 1 1 0 1 1 1 1 dUTPase Metallophos PF00149.28 ORX74473.1 - 5.4e-33 115.2 0.1 1e-32 114.3 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 ORX74473.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) F-box-like PF12937.7 ORX74474.1 - 0.037 13.9 0.3 0.25 11.3 0.0 2.6 2 1 0 2 2 2 0 F-box-like HMG_box PF00505.19 ORX74475.1 - 1.3e-23 83.1 11.3 2.3e-12 47.2 3.1 2.7 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX74475.1 - 3.9e-23 81.8 11.7 2.4e-11 44.1 0.7 2.9 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.6 ORX74475.1 - 0.0036 17.2 11.4 0.0053 16.7 0.1 3.1 3 0 0 3 3 3 2 HMG (high mobility group) box 5 NDUF_C2 PF06374.11 ORX74475.1 - 0.049 13.8 0.2 0.13 12.5 0.2 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Protamine_like PF06382.11 ORX74475.1 - 0.2 11.9 6.9 1.5 9.0 3.6 2.5 2 0 0 2 2 2 0 Protamine and protamine like LPD11 PF18824.1 ORX74475.1 - 0.98 9.5 3.1 1.1 9.4 0.5 2.2 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 Tn7_TnsC_Int PF11426.8 ORX74476.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.5 2 0 0 2 2 2 0 Tn7 transposition regulator TnsC Metallophos PF00149.28 ORX74477.1 - 1.5e-29 104.0 0.1 3.3e-29 102.9 0.1 1.6 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 ORX74477.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) NmrA PF05368.13 ORX74478.1 - 2.9e-30 105.5 0.6 1.9e-29 102.9 0.6 2.2 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX74478.1 - 3.6e-13 49.8 0.0 5.3e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX74478.1 - 6.6e-06 25.8 0.0 9.2e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX74478.1 - 0.0067 15.5 0.0 0.0096 15.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 ORX74478.1 - 0.027 14.4 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF3094 PF11293.8 ORX74478.1 - 0.051 13.3 0.0 7.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) GDP_Man_Dehyd PF16363.5 ORX74478.1 - 0.056 12.8 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 ORX74478.1 - 0.058 13.5 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase YqfD PF06898.11 ORX74478.1 - 0.064 12.1 0.0 0.14 11.0 0.0 1.5 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD Semialdhyde_dh PF01118.24 ORX74478.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 ORX74479.1 - 8.4e-27 94.0 33.6 1.2e-26 93.5 26.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX74479.1 - 0.00047 19.1 22.4 0.001 18.0 4.1 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.13 ORX74479.1 - 0.072 11.5 3.3 0.03 12.7 0.5 1.6 2 0 0 2 2 2 0 Transmembrane secretion effector DUF3446 PF11928.8 ORX74481.1 - 2.9 8.3 21.4 0.44 10.9 12.8 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain HhH-GPD PF00730.25 ORX74483.1 - 3.3e-19 69.3 0.0 4.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ORX74483.1 - 1.3e-08 34.3 0.0 6.2e-08 32.1 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ORX74483.1 - 0.0057 17.0 3.6 0.011 16.1 3.6 1.5 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III CUE PF02845.16 ORX74483.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 CUE domain HHH_5 PF14520.6 ORX74483.1 - 0.13 12.9 0.0 0.9 10.2 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain LAL_C2 PF18603.1 ORX74483.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 Methyltransf_16 PF10294.9 ORX74484.1 - 2.8e-10 40.2 0.1 1.5e-08 34.6 0.0 2.3 1 1 1 2 2 2 1 Lysine methyltransferase MTS PF05175.14 ORX74484.1 - 0.024 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ORX74484.1 - 0.041 13.6 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PBP1_TM PF14812.6 ORX74485.1 - 0.0087 16.4 3.3 0.02 15.2 3.3 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Metallopep PF12044.8 ORX74486.1 - 1.9e-119 399.1 0.0 2.3e-119 398.8 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Aa_trans PF01490.18 ORX74487.1 - 1.9e-51 175.1 29.0 2.2e-51 174.9 29.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein FAM70 PF14967.6 ORX74487.1 - 0.6 9.5 0.0 0.6 9.5 0.0 2.4 2 0 0 2 2 2 0 FAM70 protein Eclosion PF04736.12 ORX74488.1 - 2e-08 33.8 0.0 1.4 8.7 0.0 5.3 1 1 5 6 6 6 3 Eclosion hormone Wyosine_form PF08608.12 ORX74488.1 - 2.5e-07 31.0 11.8 3.5 8.0 0.1 6.7 1 1 6 7 7 7 3 Wyosine base formation RPEL PF02755.15 ORX74488.1 - 2.1e-05 24.0 35.7 0.8 9.5 0.2 9.2 9 0 0 9 9 9 2 RPEL repeat DUF3986 PF13143.6 ORX74488.1 - 6.7e-05 23.8 2.4 4.1 8.5 0.1 3.4 1 1 3 4 4 4 2 Protein of unknown function (DUF3986) DUF1398 PF07166.11 ORX74488.1 - 0.0013 18.8 0.2 20 5.3 0.1 4.2 1 1 2 4 4 4 0 Protein of unknown function (DUF1398) ATPgrasp_ST PF14397.6 ORX74488.1 - 0.011 15.0 1.1 8 5.6 0.0 3.5 2 2 1 4 4 4 0 Sugar-transfer associated ATP-grasp DUF4332 PF14229.6 ORX74488.1 - 0.11 12.8 22.3 2.3 8.5 0.2 5.2 1 1 4 6 6 6 0 Domain of unknown function (DUF4332) Terminase_3C PF17288.2 ORX74488.1 - 0.12 12.8 13.5 1.6 9.1 0.2 3.8 1 1 1 3 3 3 0 Terminase RNAseH like domain Phage_term_smal PF05944.12 ORX74488.1 - 0.87 9.6 25.6 2.3 8.2 0.6 6.3 1 1 7 8 8 8 0 Phage small terminase subunit DnaJ_CXXCXGXG PF00684.19 ORX74488.1 - 2 8.8 10.5 4.3 7.8 3.9 2.6 2 0 0 2 2 2 0 DnaJ central domain Ras_bdg_2 PF14847.6 ORX74488.1 - 2.5 8.5 10.1 12 6.3 4.3 2.9 1 1 2 3 3 3 0 Ras-binding domain of Byr2 Kisspeptin PF15152.6 ORX74488.1 - 8.2 7.3 16.0 3.1 8.6 0.6 3.7 2 2 0 3 3 3 0 Kisspeptin TIP_N PF12457.8 ORX74488.1 - 8.4 6.8 20.3 65 4.0 4.1 4.6 1 1 3 4 4 4 0 Tuftelin interacting protein N terminal dUTPase PF00692.19 ORX74490.1 - 9e-28 96.5 0.0 1.1e-27 96.3 0.0 1.0 1 0 0 1 1 1 1 dUTPase zf-CCHC_5 PF14787.6 ORX74492.1 - 0.013 15.2 1.0 0.024 14.3 1.0 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 ORX74492.1 - 0.12 12.2 0.4 0.33 10.7 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 ORX74492.1 - 0.27 11.4 0.6 0.6 10.3 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle ELFV_dehydrog PF00208.21 ORX74493.1 - 2.6e-82 276.2 1.6 3.2e-82 275.9 1.6 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ORX74493.1 - 3.1e-48 162.9 0.0 7.2e-48 161.7 0.0 1.7 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain SAM_LFY PF01698.16 ORX74493.1 - 0.0029 17.5 0.0 0.0099 15.8 0.0 1.9 2 0 0 2 2 2 1 Floricaula / Leafy protein SAM domain NAD_binding_7 PF13241.6 ORX74493.1 - 0.01 16.2 0.0 0.026 15.0 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Ribosomal_L5e PF17144.4 ORX74494.1 - 2.3e-84 281.3 0.2 3.9e-84 280.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ORX74494.1 - 4e-34 117.4 1.7 4e-34 117.4 1.7 1.9 2 1 0 2 2 2 1 Ribosomal L18 C-terminal region Cuticle_3 PF11018.8 ORX74495.1 - 0.064 13.5 47.3 0.16 12.2 30.9 2.2 1 1 1 2 2 2 0 Pupal cuticle protein C1 Pam16 PF03656.13 ORX74497.1 - 7.9e-29 100.2 1.2 8.6e-29 100.1 1.2 1.0 1 0 0 1 1 1 1 Pam16 Sec3_C PF09763.9 ORX74498.1 - 1.5e-119 400.4 2.4 1.8e-119 400.2 2.4 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 COG6 PF06419.11 ORX74498.1 - 8.6e-06 24.3 11.6 0.0057 14.9 1.8 2.3 2 0 0 2 2 2 2 Conserved oligomeric complex COG6 Sec3_C_2 PF15278.6 ORX74498.1 - 0.26 11.7 3.8 2.5 8.5 0.1 3.7 4 0 0 4 4 4 0 Sec3 exocyst complex subunit WAC_Acf1_DNA_bd PF10537.9 ORX74498.1 - 0.53 10.8 2.7 1 9.9 0.1 2.9 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal YabA PF06156.13 ORX74498.1 - 3.7 8.3 10.7 0.56 10.9 3.6 3.1 3 0 0 3 3 3 0 Initiation control protein YabA zf-HIT PF04438.16 ORX74504.1 - 1.4e-05 24.8 4.1 2.2e-05 24.2 4.1 1.3 1 0 0 1 1 1 1 HIT zinc finger AF-4 PF05110.13 ORX74504.1 - 2.2 6.3 11.8 3.5 5.6 11.8 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Carn_acyltransf PF00755.20 ORX74505.1 - 1e-120 404.2 0.0 3.3e-120 402.5 0.0 1.7 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase APG12 PF04110.13 ORX74506.1 - 2.4e-27 95.2 0.0 2.9e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Candida_ALS PF05792.13 ORX74506.1 - 0.014 15.9 1.5 0.03 14.9 1.5 1.6 1 0 0 1 1 1 0 Candida agglutinin-like (ALS) Cys_rich_KTR PF14205.6 ORX74507.1 - 0.011 15.5 0.3 0.018 14.9 0.3 1.4 1 0 0 1 1 1 0 Cysteine-rich KTR dCMP_cyt_deam_1 PF00383.23 ORX74510.1 - 3.8e-25 87.7 0.1 4.9e-25 87.3 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX74510.1 - 1.3e-22 80.0 0.0 1.7e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC3 PF18771.1 ORX74510.1 - 0.00015 21.9 0.0 0.00021 21.4 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 SNAD4 PF18750.1 ORX74510.1 - 0.00099 19.2 0.0 0.0015 18.6 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 XOO_2897-deam PF14440.6 ORX74510.1 - 0.0023 18.0 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Xanthomonas XOO_2897-like deaminase APOBEC2 PF18772.1 ORX74510.1 - 0.0051 16.9 0.0 0.0072 16.4 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 Bd3614-deam PF14439.6 ORX74510.1 - 0.0064 16.6 0.9 0.2 11.7 0.2 2.2 1 1 1 2 2 2 1 Bd3614-like deaminase NAD1 PF18778.1 ORX74510.1 - 0.011 15.9 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 NAD2 PF18782.1 ORX74510.1 - 0.018 15.2 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 ORX74510.1 - 0.038 13.9 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase TRAM_LAG1_CLN8 PF03798.16 ORX74511.1 - 4.3e-33 114.7 22.5 7.8e-33 113.9 22.5 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 ORX74511.1 - 0.00089 18.9 0.1 0.0022 17.6 0.1 1.7 1 0 0 1 1 1 1 TRAM1-like protein F-box-like PF12937.7 ORX74513.1 - 1.4e-14 53.7 1.2 2.9e-14 52.7 1.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX74513.1 - 7.4e-12 44.8 1.4 1.6e-11 43.8 1.4 1.5 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ORX74513.1 - 0.012 16.4 1.4 0.75 10.8 0.1 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat F-box_4 PF15966.5 ORX74513.1 - 0.093 12.6 0.1 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 F-box HIT PF01230.23 ORX74514.1 - 5.5e-05 23.8 0.1 8.6e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX74514.1 - 8.3e-05 23.0 0.0 0.00011 22.7 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding F-box-like PF12937.7 ORX74515.1 - 0.024 14.5 0.9 0.047 13.6 0.4 1.8 2 0 0 2 2 2 0 F-box-like F-box-like PF12937.7 ORX74516.1 - 0.002 18.0 1.4 0.002 18.0 1.4 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX74516.1 - 0.02 14.8 2.2 0.02 14.8 2.2 3.5 3 1 0 3 3 3 0 F-box domain Ceramidase PF05875.12 ORX74517.1 - 1.7e-53 181.8 19.6 1.9e-53 181.6 19.6 1.0 1 0 0 1 1 1 1 Ceramidase Chs7 PF12271.8 ORX74517.1 - 0.00083 18.8 1.8 0.0014 18.1 1.8 1.4 1 0 0 1 1 1 1 Chitin synthase export chaperone CBM_20 PF00686.19 ORX74517.1 - 0.13 12.2 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Starch binding domain LRR_6 PF13516.6 ORX74518.1 - 1.9e-20 71.1 4.0 0.00084 19.2 0.0 9.2 10 0 0 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.33 ORX74518.1 - 1.4e-05 25.0 0.1 2.7 8.9 0.0 5.9 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.6 ORX74518.1 - 0.026 14.3 9.8 4.9 7.0 0.1 5.6 5 3 0 5 5 5 0 Leucine rich repeat LRR_4 PF12799.7 ORX74518.1 - 0.048 14.1 8.8 6.9 7.2 0.0 5.7 2 2 5 7 7 7 0 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX74518.1 - 0.073 12.6 0.0 0.49 9.9 0.0 2.3 2 1 1 3 3 3 0 Leucine-rich repeat AA_permease PF00324.21 ORX74521.1 - 2.3e-105 352.9 45.6 8.5e-105 351.1 45.6 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX74521.1 - 2.7e-32 112.2 44.0 3.8e-32 111.6 44.0 1.2 1 0 0 1 1 1 1 Amino acid permease Cytochrom_B_C PF00032.17 ORX74521.1 - 0.34 11.2 8.9 0.064 13.6 2.7 2.7 3 0 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD 7TM_transglut PF14402.6 ORX74521.1 - 2.1 7.8 12.5 11 5.4 0.3 2.6 2 1 0 2 2 2 0 7 transmembrane helices usually fused to an inactive transglutaminase SDF PF00375.18 ORX74523.1 - 3.1e-96 322.8 30.7 3.7e-96 322.5 30.7 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family p47_phox_C PF08944.11 ORX74523.1 - 0.0048 16.3 0.2 0.18 11.3 0.0 2.3 2 0 0 2 2 2 1 NADPH oxidase subunit p47Phox, C terminal domain DUF2897 PF11446.8 ORX74523.1 - 0.06 13.2 2.9 0.23 11.4 2.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Aa_trans PF01490.18 ORX74524.1 - 4.2e-39 134.4 33.5 9e-22 77.3 11.3 2.5 2 1 1 3 3 3 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX74524.1 - 8e-06 25.1 11.2 8e-06 25.1 11.2 2.4 2 1 1 3 3 3 1 Tryptophan/tyrosine permease family MacB_PCD PF12704.7 ORX74524.1 - 0.93 9.8 0.0 0.93 9.8 0.0 2.3 2 2 0 2 2 2 0 MacB-like periplasmic core domain DUF5090 PF17009.5 ORX74524.1 - 1.4 8.8 7.6 1 9.3 1.8 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5090) 7tm_7 PF08395.12 ORX74524.1 - 4.4 6.4 19.6 0.1 11.8 1.7 2.9 4 0 0 4 4 4 0 7tm Chemosensory receptor PIN_4 PF13638.6 ORX74525.1 - 8.1e-16 58.5 0.0 3.1e-14 53.4 0.0 2.5 1 1 0 1 1 1 1 PIN domain RhaA PF06134.11 ORX74525.1 - 0.004 16.3 0.0 0.0058 15.8 0.0 1.2 1 0 0 1 1 1 1 L-rhamnose isomerase (RhaA) PIN_9 PF18477.1 ORX74525.1 - 0.14 12.5 0.1 0.48 10.7 0.0 1.8 2 0 0 2 2 2 0 PIN like domain RRM_1 PF00076.22 ORX74526.1 - 1e-20 73.3 0.8 2e-13 49.9 0.0 3.9 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BMP2K_C PF15282.6 ORX74526.1 - 0.025 14.5 2.9 2.3 8.0 1.1 2.7 2 1 0 2 2 2 0 BMP-2-inducible protein kinase C-terminus ATP-synt_Eps PF04627.13 ORX74526.1 - 0.042 13.8 1.4 0.19 11.8 1.4 2.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain Ion_trans_2 PF07885.16 ORX74528.1 - 9.4e-13 47.9 5.1 9.4e-13 47.9 5.1 2.0 2 0 0 2 2 2 1 Ion channel PIRT PF15099.6 ORX74528.1 - 0.062 12.9 0.1 0.17 11.4 0.1 1.7 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family TauE PF01925.19 ORX74528.1 - 0.075 12.7 8.1 0.032 13.9 3.3 2.0 1 1 1 2 2 2 0 Sulfite exporter TauE/SafE Vma12 PF11712.8 ORX74528.1 - 0.22 11.6 0.2 0.47 10.5 0.2 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2975 PF11188.8 ORX74528.1 - 5.4 6.9 7.5 11 6.0 0.0 3.6 3 2 1 4 4 4 0 Protein of unknown function (DUF2975) DUF3605 PF12239.8 ORX74529.1 - 3.4e-09 37.2 0.0 0.00047 20.5 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3605) Trehalase PF01204.18 ORX74530.1 - 8.8e-67 226.1 0.2 4.5e-42 144.6 0.0 2.5 3 0 0 3 3 3 2 Trehalase PT PF04886.12 ORX74530.1 - 0.012 15.1 26.3 0.024 14.2 26.3 1.5 1 0 0 1 1 1 0 PT repeat AF-4 PF05110.13 ORX74530.1 - 0.022 12.9 1.0 0.032 12.4 1.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TonB_N PF16031.5 ORX74530.1 - 0.8 10.2 17.3 1.7 9.2 17.3 1.4 1 0 0 1 1 1 0 TonB polyproline region Trypan_PARP PF05887.11 ORX74530.1 - 9.8 6.2 15.6 19 5.2 15.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) HMG_box PF00505.19 ORX74531.1 - 1.5e-08 34.9 0.3 2.8e-08 34.1 0.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX74531.1 - 1.4e-07 32.0 0.5 3.6e-07 30.7 0.2 1.7 2 0 0 2 2 2 1 HMG-box domain Aa_trans PF01490.18 ORX74532.1 - 3e-53 181.0 24.2 3e-53 181.0 24.2 1.7 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein MFS_1 PF07690.16 ORX74533.1 - 7.5e-51 173.1 22.8 7.5e-51 173.1 22.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 ORX74533.1 - 5.7e-07 29.1 10.4 5.7e-07 29.1 10.4 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 ORX74533.1 - 8.6e-07 28.1 17.7 0.0007 18.5 8.8 3.6 1 1 0 2 2 2 2 MFS_1 like family OATP PF03137.20 ORX74533.1 - 4.5e-06 25.2 10.9 0.022 13.0 0.9 4.1 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 ORX74533.1 - 0.00044 18.8 6.1 0.00044 18.8 6.1 2.1 1 1 1 2 2 2 1 Transmembrane secretion effector LacY_symp PF01306.19 ORX74533.1 - 0.83 8.4 18.5 31 3.2 18.5 2.5 1 1 0 1 1 1 0 LacY proton/sugar symporter PQ-loop PF04193.14 ORX74535.1 - 6.4e-36 121.9 11.7 1.2e-19 69.8 0.9 2.5 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 ORX74535.1 - 0.041 14.7 2.3 2.6 8.9 0.0 2.6 2 1 0 2 2 2 0 ER lumen protein retaining receptor Mito_carr PF00153.27 ORX74536.1 - 7.7e-69 227.7 1.0 8e-23 80.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 ORX74539.1 - 1.2e-09 37.7 0.8 1.4e-09 37.4 0.8 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX74540.1 - 0.001 19.1 5.2 0.0021 18.2 5.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 ORX74540.1 - 3.1 7.9 7.0 4.3 7.5 2.8 2.5 1 1 1 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Abhydrolase_1 PF00561.20 ORX74541.1 - 1.8e-52 178.5 0.0 3.8e-52 177.5 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX74541.1 - 0.026 15.1 0.0 0.046 14.3 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Ndr PF03096.14 ORX74541.1 - 0.14 10.8 0.0 0.27 9.9 0.0 1.4 1 0 0 1 1 1 0 Ndr family FAD_binding_8 PF08022.12 ORX74543.1 - 1.1e-21 77.0 0.0 1.8e-20 73.0 0.0 2.3 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ORX74543.1 - 4.8e-17 62.5 0.0 7.6e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ORX74543.1 - 1.5e-09 38.0 7.9 2.9e-09 37.1 7.9 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX74543.1 - 0.028 15.0 0.0 0.052 14.2 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF824 PF05688.11 ORX74543.1 - 0.2 11.5 0.0 0.4 10.5 0.0 1.5 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) CARD_2 PF16739.5 ORX74543.1 - 0.26 11.3 0.2 26 4.9 0.1 2.4 2 0 0 2 2 2 0 Caspase recruitment domain Ofd1_CTDD PF10637.9 ORX74544.1 - 3.1e-70 236.5 0.0 3e-64 216.8 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ORX74544.1 - 6.6e-28 97.2 0.0 1.3e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ORX74544.1 - 2.8e-15 57.0 0.0 5.5e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 ORX74544.1 - 0.094 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA HsbA PF12296.8 ORX74545.1 - 0.016 15.6 1.9 3.7 8.0 0.3 2.6 2 0 0 2 2 2 0 Hydrophobic surface binding protein A DUF4775 PF16001.5 ORX74546.1 - 0.41 10.0 2.5 0.42 10.0 2.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Guanylate_cyc_2 PF09778.9 ORX74547.1 - 6.8e-52 175.9 0.0 7.7e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39 PF03412.15 ORX74547.1 - 0.0023 17.8 0.0 0.0048 16.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase C39 family Peptidase_C39_2 PF13529.6 ORX74547.1 - 0.0094 16.5 0.1 0.36 11.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase_C39 like family GRAM PF02893.20 ORX74549.1 - 7.7e-07 29.0 0.0 0.045 13.6 0.0 2.3 2 0 0 2 2 2 2 GRAM domain PQ-loop PF04193.14 ORX74552.1 - 2.2e-21 75.4 0.5 4.4e-21 74.4 0.5 1.5 1 0 0 1 1 1 1 PQ loop repeat DUF3151 PF11349.8 ORX74552.1 - 0.1 12.7 0.5 0.14 12.2 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3151) PQ-loop PF04193.14 ORX74553.1 - 9.3e-18 63.8 1.1 1.6e-17 63.0 1.1 1.4 1 0 0 1 1 1 1 PQ loop repeat EzrA PF06160.12 ORX74554.1 - 5.9e-05 21.4 9.7 5.9e-05 21.4 9.7 1.7 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA DUF4515 PF14988.6 ORX74554.1 - 0.0033 17.3 7.1 0.0033 17.3 7.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4515) APG6_N PF17675.1 ORX74554.1 - 0.011 16.2 7.0 0.011 16.2 7.0 3.9 4 0 0 4 4 4 0 Apg6 coiled-coil region NPV_P10 PF05531.12 ORX74554.1 - 2.6 8.6 10.2 0.78 10.2 1.4 3.6 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 ORX74554.1 - 4.1 7.7 6.9 6.9 7.0 0.5 3.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF725 PF05267.12 ORX74554.1 - 8.8 6.3 9.6 0.7 9.9 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF725) NAD_binding_6 PF08030.12 ORX74556.1 - 5.4e-23 81.8 0.0 1e-22 81.0 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 ORX74556.1 - 2.6e-15 56.7 7.2 2.6e-15 56.7 7.2 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX74556.1 - 0.012 16.2 0.0 0.23 12.1 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain YgbB PF02542.16 ORX74557.1 - 0.062 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 YgbB family AAA PF00004.29 ORX74558.1 - 6.8e-96 317.8 0.0 2.6e-47 160.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX74558.1 - 2e-26 91.5 7.1 1.5e-12 47.1 0.2 3.4 3 1 0 3 3 3 2 AAA+ lid domain CDC48_N PF02359.18 ORX74558.1 - 1.1e-19 70.4 0.1 2.9e-19 69.0 0.1 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 ORX74558.1 - 3.2e-14 53.0 0.0 4.7e-06 26.4 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX74558.1 - 9.7e-13 48.6 0.0 4.6e-07 30.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 ORX74558.1 - 3.6e-11 42.7 0.0 8e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 ORX74558.1 - 5.2e-11 42.9 0.0 9.6e-06 25.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ORX74558.1 - 8.3e-11 42.6 0.2 0.002 18.6 0.0 4.2 3 2 1 4 4 3 2 AAA ATPase domain AAA_5 PF07728.14 ORX74558.1 - 1e-10 41.7 0.2 2.3e-05 24.4 0.1 3.4 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 ORX74558.1 - 3.9e-09 36.4 0.3 8.4e-06 25.7 0.1 2.8 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 ORX74558.1 - 2.1e-08 33.8 0.1 0.00084 18.6 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 ORX74558.1 - 2.8e-08 34.1 0.1 0.026 14.8 0.1 3.9 2 2 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ORX74558.1 - 9.8e-08 32.3 0.0 0.0045 17.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 ORX74558.1 - 2.4e-07 30.4 0.2 0.026 13.9 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ORX74558.1 - 3.3e-07 30.4 0.0 0.01 15.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ORX74558.1 - 7.9e-07 29.7 0.0 0.059 13.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ORX74558.1 - 2.3e-06 27.5 0.0 0.064 13.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 ORX74558.1 - 4.6e-06 27.0 0.0 0.19 11.9 0.0 3.5 4 0 0 4 4 3 2 AAA domain ATPase PF06745.13 ORX74558.1 - 5.1e-06 26.0 0.1 0.31 10.3 0.0 3.4 3 0 0 3 3 3 2 KaiC ABC_tran PF00005.27 ORX74558.1 - 5.6e-06 26.9 0.0 0.029 14.9 0.0 3.4 2 1 0 2 2 2 1 ABC transporter Parvo_NS1 PF01057.17 ORX74558.1 - 8.9e-06 25.0 0.1 0.045 12.8 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 ORX74558.1 - 1.5e-05 24.6 0.0 0.043 13.3 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 ORX74558.1 - 3.1e-05 23.8 0.0 0.05 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 ORX74558.1 - 3.2e-05 23.9 0.0 0.22 11.3 0.0 3.5 4 0 0 4 4 4 2 Bacterial dnaA protein AAA_17 PF13207.6 ORX74558.1 - 4e-05 24.0 0.3 0.37 11.2 0.0 3.1 3 0 0 3 3 2 2 AAA domain Viral_helicase1 PF01443.18 ORX74558.1 - 8.3e-05 22.4 0.0 0.0089 15.8 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 ORX74558.1 - 9.3e-05 22.2 0.0 0.55 9.9 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain ATPase_2 PF01637.18 ORX74558.1 - 9.5e-05 22.4 0.0 0.66 9.8 0.0 2.7 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea DUF815 PF05673.13 ORX74558.1 - 0.00015 21.0 0.0 0.081 12.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 ORX74558.1 - 0.00015 21.7 0.0 0.65 10.0 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ORX74558.1 - 0.00019 21.1 4.2 3.5 7.2 0.2 4.0 2 2 0 3 3 3 1 AAA domain AAA_3 PF07726.11 ORX74558.1 - 0.0003 20.6 0.0 1.3 8.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 ORX74558.1 - 0.00076 19.5 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX74558.1 - 0.00082 18.9 0.2 0.68 9.4 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein NACHT PF05729.12 ORX74558.1 - 0.00087 19.2 0.1 1.5 8.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Zeta_toxin PF06414.12 ORX74558.1 - 0.00092 18.5 0.0 1.2 8.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin NB-ARC PF00931.22 ORX74558.1 - 0.0012 18.1 0.0 0.55 9.4 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain AAA_11 PF13086.6 ORX74558.1 - 0.0015 18.4 0.5 1.8 8.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 ORX74558.1 - 0.0046 16.2 0.9 0.56 9.4 0.0 2.6 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 ORX74558.1 - 0.0077 16.2 0.0 0.58 10.0 0.0 2.5 2 1 0 2 2 2 1 Rad17 P-loop domain NTPase_1 PF03266.15 ORX74558.1 - 0.013 15.5 1.1 8.5 6.3 0.0 4.2 4 1 1 5 5 5 0 NTPase Sigma54_activ_2 PF14532.6 ORX74558.1 - 0.018 15.2 0.0 8.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 ORX74558.1 - 0.021 14.6 0.1 7.2 6.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX74558.1 - 0.027 14.8 0.9 12 6.3 0.0 2.9 2 1 0 3 3 2 0 AAA domain Cytidylate_kin2 PF13189.6 ORX74558.1 - 0.03 14.5 0.0 2.9 8.0 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase-like family Zot PF05707.12 ORX74558.1 - 0.19 11.3 0.0 2.7 7.6 0.0 2.4 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) DcpS_C PF11969.8 ORX74559.1 - 2.6e-17 63.3 0.0 2.7e-17 63.3 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ORX74559.1 - 3.3e-10 40.6 0.0 3.8e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 HIT domain ATG16 PF08614.11 ORX74560.1 - 0.35 11.1 4.8 0.43 10.8 4.8 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) MutS_V PF00488.21 ORX74561.1 - 2.6e-69 233.1 0.1 4.5e-69 232.2 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 ORX74561.1 - 1.7e-19 70.1 0.0 3.3e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ORX74561.1 - 1.5e-13 51.2 0.0 3.2e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 MutS domain II MutS_III PF05192.18 ORX74561.1 - 6.6e-09 36.3 0.0 2.6e-07 31.0 0.0 2.6 2 1 1 3 3 3 1 MutS domain III MutS_IV PF05190.18 ORX74561.1 - 2.8e-07 30.8 0.1 1.1e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV AAA_28 PF13521.6 ORX74561.1 - 0.055 13.7 0.0 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.21 ORX74562.1 - 0.0018 17.6 0.0 1.4 8.0 0.0 2.9 1 1 2 3 3 3 3 Aminotransferase class I and II zf-CSL PF05207.13 ORX74563.1 - 2e-24 85.1 1.7 2.6e-24 84.7 1.7 1.2 1 0 0 1 1 1 1 CSL zinc finger zinc_ribbon_4 PF13717.6 ORX74563.1 - 0.03 14.2 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-RING_7 PF02591.15 ORX74563.1 - 0.054 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 C4-type zinc ribbon domain zf-RING_4 PF14570.6 ORX74563.1 - 0.27 11.1 3.0 0.56 10.0 3.0 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ABC_membrane PF00664.23 ORX74564.1 - 5.3e-29 101.7 4.8 1.1e-28 100.7 4.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX74564.1 - 3.2e-16 60.1 0.0 1.7e-15 57.7 0.0 2.2 1 1 0 1 1 1 1 ABC transporter GST_C_2 PF13410.6 ORX74564.1 - 0.00086 19.3 0.1 0.0031 17.5 0.1 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AAA_29 PF13555.6 ORX74564.1 - 0.001 18.7 0.1 0.0048 16.6 0.1 2.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX74564.1 - 0.0011 19.3 0.0 0.0033 17.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX74564.1 - 0.0038 17.5 0.0 0.016 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX74564.1 - 0.0039 17.1 0.0 0.011 15.7 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 ORX74564.1 - 0.0073 16.1 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ORX74564.1 - 0.047 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX74564.1 - 0.078 13.5 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ORX74564.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ORX74564.1 - 0.24 11.1 0.0 0.24 11.1 0.0 2.8 3 1 0 3 3 3 0 AAA domain TMEM223 PF14640.6 ORX74565.1 - 4e-18 66.1 0.0 5.5e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 Bmt2 PF11968.8 ORX74566.1 - 3.8e-35 121.7 0.0 5.4e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 DUF1926 PF09095.11 ORX74566.1 - 0.057 13.0 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1926) ADH_zinc_N PF00107.26 ORX74568.1 - 1e-23 83.7 0.0 1.6e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX74568.1 - 2.1e-21 77.3 0.1 4.6e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX74568.1 - 4.4e-09 36.2 0.0 9.6e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ORX74568.1 - 0.00067 19.5 0.0 0.0029 17.5 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase HupF_HypC PF01455.18 ORX74568.1 - 0.0053 16.9 0.2 0.027 14.6 0.0 2.2 2 0 0 2 2 2 1 HupF/HypC family TrkA_N PF02254.18 ORX74568.1 - 0.008 16.4 0.1 0.019 15.2 0.1 1.7 2 0 0 2 2 2 1 TrkA-N domain PA PF02225.22 ORX74568.1 - 0.06 13.4 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 PA domain HLH PF00010.26 ORX74569.1 - 2e-14 53.3 2.8 3.9e-14 52.3 2.4 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Minor_capsid_2 PF11114.8 ORX74569.1 - 0.023 14.7 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Minor capsid protein Glyco_hydro_47 PF01532.20 ORX74572.1 - 2.6e-49 168.4 2.6 3.1e-45 155.0 1.5 2.4 2 1 0 2 2 2 2 Glycosyl hydrolase family 47 PA PF02225.22 ORX74572.1 - 0.1 12.6 0.1 0.24 11.4 0.1 1.7 1 1 0 1 1 1 0 PA domain DUF4449 PF14613.6 ORX74573.1 - 7.3e-05 22.9 11.1 7.3e-05 22.9 11.1 4.2 2 2 3 5 5 5 1 Protein of unknown function (DUF4449) DUF883 PF05957.13 ORX74573.1 - 0.0029 18.2 46.4 0.26 11.9 3.4 6.8 5 2 2 7 7 7 4 Bacterial protein of unknown function (DUF883) BLYB PF05289.11 ORX74573.1 - 0.022 15.0 0.9 0.21 11.8 0.4 2.7 2 0 0 2 2 2 0 Borrelia hemolysin accessory protein Mitofilin PF09731.9 ORX74573.1 - 0.038 12.8 40.7 0.0043 16.0 21.9 2.4 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Syntaxin-6_N PF09177.11 ORX74573.1 - 1.9 9.1 9.1 4.5 7.9 0.4 4.5 4 1 1 5 5 5 0 Syntaxin 6, N-terminal Transketolase_C PF02780.20 ORX74574.1 - 3.3e-41 140.1 0.0 7.6e-41 138.9 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 ORX74574.1 - 3.9e-40 137.4 0.1 8.2e-40 136.4 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 ORX74574.1 - 0.00053 20.3 0.0 0.0018 18.5 0.0 1.9 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II HLH PF00010.26 ORX74575.1 - 1.4e-14 53.7 1.0 2.5e-14 52.9 1.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HLH PF00010.26 ORX74576.1 - 3.1e-10 39.8 1.1 3.1e-10 39.8 1.1 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Arb1 PF09692.10 ORX74577.1 - 8e-09 35.2 0.0 9.5e-06 25.0 0.0 2.2 1 1 0 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 SNO PF01174.19 ORX74578.1 - 5.1e-44 150.4 0.0 9.3e-42 143.0 0.0 2.1 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 ORX74578.1 - 0.00027 20.6 0.0 0.0009 18.9 0.0 1.7 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 ORX74578.1 - 0.081 12.7 0.0 2.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Glutamine amidotransferase class-I CWC25 PF12542.8 ORX74581.1 - 2.6e-19 70.0 2.6 2.6e-19 70.0 2.6 3.2 3 1 0 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 ORX74581.1 - 1e-08 35.2 8.5 1e-08 35.2 8.5 3.0 3 1 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR Rab5ip PF07019.12 ORX74582.1 - 9.4e-19 67.8 8.4 1.2e-18 67.5 8.4 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Repressor_Mnt PF11423.8 ORX74582.1 - 0.072 12.9 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Regulatory protein Mnt zf-C3HC4_2 PF13923.6 ORX74583.1 - 4.1e-10 39.3 13.1 4.1e-10 39.3 13.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX74583.1 - 1.6e-08 34.2 13.4 1.6e-08 34.2 13.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX74583.1 - 7.3e-08 32.3 5.2 7.3e-08 32.3 5.2 2.4 2 1 1 3 3 2 1 RING-type zinc-finger SAP PF02037.27 ORX74583.1 - 4.7e-07 29.4 0.2 1.1e-06 28.2 0.2 1.7 1 0 0 1 1 1 1 SAP domain zf-C3HC4_3 PF13920.6 ORX74583.1 - 1.2e-06 28.3 11.3 1.2e-06 28.3 11.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX74583.1 - 2.6e-06 27.5 8.7 2.6e-06 27.5 8.7 2.6 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ORX74583.1 - 3.4e-06 26.8 4.2 3.4e-06 26.8 4.2 1.7 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 ORX74583.1 - 9e-06 25.6 11.5 9e-06 25.6 11.5 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ORX74583.1 - 1.2e-05 25.5 12.7 1.2e-05 25.5 12.7 2.5 3 0 0 3 3 2 1 Ring finger domain zf-rbx1 PF12678.7 ORX74583.1 - 0.00025 21.3 8.8 0.00025 21.3 8.8 2.4 3 0 0 3 3 2 1 RING-H2 zinc finger domain RNF220 PF15926.5 ORX74583.1 - 0.002 17.8 1.4 0.002 17.8 1.4 2.3 1 1 2 3 3 3 1 E3 ubiquitin-protein ligase RNF220 Prok-RING_4 PF14447.6 ORX74583.1 - 0.0021 17.9 17.3 0.13 12.2 13.8 3.4 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 PRP21_like_P PF12230.8 ORX74583.1 - 0.0048 16.8 0.2 0.037 13.9 0.0 2.5 3 0 0 3 3 3 1 Pre-mRNA splicing factor PRP21 like protein zf-RING_10 PF16685.5 ORX74583.1 - 0.0073 16.4 7.9 0.0073 16.4 7.9 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 Sgf11 PF08209.11 ORX74583.1 - 0.008 15.7 0.2 0.008 15.7 0.2 3.6 3 1 0 3 3 3 1 Sgf11 (transcriptional regulation protein) zf-RING_7 PF02591.15 ORX74583.1 - 0.0084 16.3 6.1 0.34 11.1 0.1 3.1 3 0 0 3 3 2 2 C4-type zinc ribbon domain zf-Nse PF11789.8 ORX74583.1 - 0.0097 15.7 6.9 0.0097 15.7 6.9 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 ORX74583.1 - 0.031 14.4 0.1 2.3 8.5 0.0 2.6 2 0 0 2 2 2 0 U-box domain zf-WRNIP1_ubi PF18279.1 ORX74583.1 - 0.032 14.9 5.4 5.7 7.8 0.0 4.0 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-ribbon_3 PF13248.6 ORX74583.1 - 0.033 13.6 0.1 0.033 13.6 0.1 3.8 3 1 0 3 3 3 0 zinc-ribbon domain UBZ_FAAP20 PF15750.5 ORX74583.1 - 0.038 13.9 12.8 0.18 11.8 0.0 4.6 4 1 0 4 4 4 0 Ubiquitin-binding zinc-finger zf-ANAPC11 PF12861.7 ORX74583.1 - 0.06 13.4 6.2 0.14 12.2 6.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf_UBZ PF18439.1 ORX74583.1 - 0.14 11.7 4.2 1.9 8.1 0.0 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 ORX74583.1 - 0.23 11.8 13.0 11 6.4 0.1 3.8 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 ORX74583.1 - 0.44 10.6 14.9 3.1 7.9 0.1 3.1 2 1 0 2 2 2 0 Double zinc ribbon DNA_ligase_ZBD PF03119.16 ORX74583.1 - 0.44 10.6 6.3 2.7 8.1 0.4 3.6 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-RING_4 PF14570.6 ORX74583.1 - 0.84 9.5 17.1 0.3 10.9 12.1 2.6 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Zn-ribbon_8 PF09723.10 ORX74583.1 - 0.96 9.6 17.5 1.1 9.5 0.2 3.7 4 0 0 4 4 3 0 Zinc ribbon domain zf-LITAF-like PF10601.9 ORX74583.1 - 2.4 8.5 17.0 6.6 7.1 0.3 3.3 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain zf-TFIIB PF13453.6 ORX74583.1 - 7.1 6.0 8.6 3.5 7.0 0.2 3.1 3 0 0 3 3 3 0 Transcription factor zinc-finger Prok-RING_1 PF14446.6 ORX74583.1 - 8.5 6.4 10.6 11 6.0 0.1 3.5 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 NIF PF03031.18 ORX74584.1 - 2.6e-24 85.7 0.0 4.7e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF737 PF05300.11 ORX74584.1 - 0.046 14.1 3.0 1 9.7 0.3 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF737) Fungal_TACC PF12709.7 ORX74584.1 - 3 8.3 6.8 0.83 10.1 2.8 2.0 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins NAD_binding_10 PF13460.6 ORX74585.1 - 3e-37 128.3 0.6 3.6e-37 128.0 0.6 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX74585.1 - 4.3e-08 33.0 2.1 6.2e-06 25.9 0.8 2.2 2 0 0 2 2 2 2 NmrA-like family Epimerase PF01370.21 ORX74585.1 - 7e-08 32.2 0.1 1e-07 31.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX74585.1 - 0.00024 20.2 0.0 0.00029 19.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 ORX74585.1 - 0.00077 19.7 0.5 0.0012 19.1 0.5 1.4 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 ORX74585.1 - 0.0019 17.8 0.4 0.0028 17.3 0.4 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 ORX74585.1 - 0.0042 17.1 0.1 0.0061 16.6 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 ORX74585.1 - 0.0047 16.1 0.2 0.15 11.2 0.2 2.2 1 1 0 1 1 1 1 Male sterility protein CdAMP_rec PF06153.11 ORX74585.1 - 0.0085 16.3 0.3 0.026 14.7 0.1 1.8 2 0 0 2 2 2 1 Cyclic-di-AMP receptor PEP_hydrolase PF09370.10 ORX74585.1 - 0.032 13.5 0.2 0.042 13.1 0.2 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like DapB_N PF01113.20 ORX74585.1 - 0.072 13.2 0.7 0.43 10.7 0.7 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 ORX74585.1 - 0.12 12.9 0.1 0.2 12.1 0.1 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain eRF1_1 PF03463.15 ORX74587.1 - 8.9e-35 119.5 0.2 2.8e-32 111.4 0.2 2.4 1 1 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 ORX74587.1 - 8.2e-20 71.4 0.1 1.4e-18 67.4 0.0 2.7 2 2 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.15 ORX74587.1 - 9.3e-20 71.3 1.0 1.6e-19 70.6 1.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 Glyco_trans_1_4 PF13692.6 ORX74587.1 - 0.12 12.8 0.1 13 6.2 0.0 2.6 3 0 0 3 3 3 0 Glycosyl transferases group 1 cwf21 PF08312.12 ORX74588.1 - 1.7e-13 50.5 8.9 1.7e-13 50.5 8.9 2.0 3 0 0 3 3 3 1 cwf21 domain MOZ_SAS PF01853.18 ORX74589.1 - 1.2e-63 214.0 0.0 1.5e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX74589.1 - 9e-17 60.4 0.4 9e-17 60.4 0.4 1.8 2 0 0 2 2 2 1 MYST family zinc finger domain Arrestin_N PF00339.29 ORX74590.1 - 1.2e-07 31.9 0.0 4.8e-06 26.7 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX74590.1 - 9.4e-07 29.4 0.5 0.0031 18.0 0.6 3.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 ORX74590.1 - 0.00036 20.3 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like zf-C2H2_4 PF13894.6 ORX74591.1 - 0.14 13.0 0.2 0.37 11.7 0.2 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Fibrillarin PF01269.17 ORX74592.1 - 5.1e-93 310.3 0.1 9.8e-93 309.4 0.1 1.4 1 1 0 1 1 1 1 Fibrillarin DUF1769 PF08588.10 ORX74593.1 - 2.8e-11 43.4 0.1 6.2e-11 42.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) AMP-binding PF00501.28 ORX74594.1 - 2.5e-76 257.0 0.0 2.4e-75 253.7 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme WD40 PF00400.32 ORX74595.1 - 2.1e-12 47.4 0.3 0.00044 21.0 0.1 4.9 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74595.1 - 3e-05 24.2 0.0 0.032 14.5 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX74595.1 - 0.00061 19.7 0.0 0.0025 17.7 0.0 1.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX74595.1 - 0.011 14.3 0.0 0.036 12.6 0.0 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain NAD_binding_6 PF08030.12 ORX74596.1 - 1.2e-22 80.7 0.0 2.4e-22 79.7 0.0 1.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX74596.1 - 3.4e-16 59.3 0.0 6e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ORX74596.1 - 7.6e-09 35.8 4.4 7.6e-09 35.8 4.4 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 ORX74596.1 - 0.0016 19.1 0.0 0.23 12.1 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Pkinase PF00069.25 ORX74597.1 - 8.8e-69 231.8 0.0 1.3e-68 231.3 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74597.1 - 1.5e-29 103.1 0.0 3.5e-29 101.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX74597.1 - 4.7e-07 29.4 1.7 0.047 13.0 0.0 3.1 2 1 1 3 3 3 3 Kinase-like Kdo PF06293.14 ORX74597.1 - 0.031 13.6 0.2 0.053 12.9 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TrmO_C PF18389.1 ORX74597.1 - 0.055 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 TrmO C-terminal domain Forkhead PF00250.18 ORX74598.1 - 3.4e-35 120.2 0.2 3.7e-35 120.1 0.2 1.0 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 ORX74598.1 - 0.016 15.6 0.0 0.021 15.2 0.0 1.2 1 0 0 1 1 1 0 linker histone H1 and H5 family Ran_BP1 PF00638.18 ORX74599.1 - 2.9e-38 130.9 3.7 9.4e-38 129.2 3.7 1.7 1 1 0 1 1 1 1 RanBP1 domain APS_kinase PF01583.20 ORX74600.1 - 2.8e-36 124.8 1.9 6.5e-25 87.9 0.2 2.6 1 1 1 2 2 2 2 Adenylylsulphate kinase AAA_18 PF13238.6 ORX74600.1 - 0.004 17.7 0.0 0.0052 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ORX74600.1 - 0.01 15.3 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 ORX74600.1 - 0.012 15.8 0.1 0.036 14.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX74600.1 - 0.015 15.7 0.0 0.015 15.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Torsin PF06309.11 ORX74600.1 - 0.042 13.9 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Torsin DUF463 PF04317.12 ORX74600.1 - 0.045 12.7 0.1 0.056 12.4 0.1 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_29 PF13555.6 ORX74600.1 - 0.049 13.4 0.1 0.073 12.8 0.1 1.2 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ORX74600.1 - 0.17 12.3 0.0 0.31 11.5 0.0 1.5 2 0 0 2 2 2 0 RNA helicase 6PF2K PF01591.18 ORX74600.1 - 0.18 11.1 0.0 0.25 10.6 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase PRK PF00485.18 ORX74600.1 - 0.19 11.5 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SMC_N PF02463.19 ORX74601.1 - 3.4e-59 199.9 3.2 5.2e-59 199.3 3.2 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX74601.1 - 2.5e-18 66.5 0.1 8.7e-18 64.7 0.1 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX74601.1 - 1e-09 38.7 12.7 3.2e-05 23.9 0.4 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX74601.1 - 2.5e-07 31.4 14.9 2.5e-07 31.4 14.9 6.7 1 1 3 5 5 5 2 AAA domain AAA_29 PF13555.6 ORX74601.1 - 6e-05 22.7 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 ORX74601.1 - 0.00025 20.1 13.4 0.00025 20.1 13.4 6.8 3 2 3 7 7 7 2 Spc7 kinetochore protein Rad17 PF03215.15 ORX74602.1 - 0.0055 16.7 0.0 0.019 14.9 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain PBP1_TM PF14812.6 ORX74602.1 - 0.014 15.8 3.9 0.04 14.3 3.9 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA_16 PF13191.6 ORX74602.1 - 0.13 12.7 0.0 0.49 10.8 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX74602.1 - 0.13 12.7 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zip PF02535.22 ORX74606.1 - 0.89 8.7 6.9 1.4 8.1 6.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pkinase PF00069.25 ORX74608.1 - 3.9e-24 85.4 0.0 1e-23 84.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74608.1 - 4.4e-10 39.3 0.0 7.7e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX74608.1 - 0.0035 16.7 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX74608.1 - 0.0055 16.0 0.0 1.5 8.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX74608.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ORX74608.1 - 0.059 13.3 0.0 0.19 11.6 0.0 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 ORX74609.1 - 5.1e-05 22.8 0.0 6.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain FYDLN_acid PF09538.10 ORX74609.1 - 2.2 9.0 8.1 9.7 6.9 6.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) MFS_1 PF07690.16 ORX74610.1 - 7.7e-37 127.0 23.8 1.1e-36 126.5 23.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Response_reg PF00072.24 ORX74611.1 - 3.4e-05 24.0 0.1 4.3e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain UPF0029 PF01205.19 ORX74612.1 - 1.1e-33 115.7 0.0 1.6e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 ORX74612.1 - 8e-12 45.5 0.0 1.3e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 RWD domain ThrE PF06738.12 ORX74613.1 - 9.5e-57 192.1 24.7 1.3e-50 172.0 3.6 2.1 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX74613.1 - 1.5e-10 41.3 26.7 2.9e-10 40.4 13.3 3.4 3 1 1 4 4 4 2 Threonine/Serine exporter, ThrE Phage_holin_2_1 PF04971.12 ORX74613.1 - 0.28 11.2 0.1 0.28 11.2 0.1 3.4 2 2 1 3 3 3 0 Bacteriophage P21 holin S Glyco_hydro_72 PF03198.14 ORX74614.1 - 8.6e-112 373.5 4.7 1.6e-111 372.6 4.7 1.4 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ORX74614.1 - 4.5e-15 56.1 5.0 1.4e-14 54.5 5.0 1.9 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 ORX74614.1 - 0.00026 20.5 1.3 0.00071 19.1 1.0 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_cc PF11790.8 ORX74614.1 - 0.025 14.1 0.1 0.042 13.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core ICMT PF04140.14 ORX74615.1 - 2.3e-25 88.8 0.4 2.3e-25 88.8 0.4 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ORX74615.1 - 1.4e-11 44.7 0.8 1.4e-11 44.7 0.8 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 ORX74615.1 - 1.3e-05 24.8 0.1 1.9e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 ORX74615.1 - 0.0011 18.5 0.7 0.0016 18.0 0.0 1.6 2 0 0 2 2 2 1 NnrU protein ERG4_ERG24 PF01222.17 ORX74615.1 - 0.0057 15.5 0.2 0.0097 14.7 0.2 1.4 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF3836 PF12930.7 ORX74615.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF3836) Muskelin_N PF06588.11 ORX74616.1 - 1.7e-73 246.8 0.4 3.7e-73 245.7 0.3 1.6 2 0 0 2 2 2 1 Muskelin N-terminus Kelch_3 PF13415.6 ORX74616.1 - 3.7e-13 49.4 12.6 3.9e-08 33.4 0.9 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX74616.1 - 6.4e-12 45.2 6.8 6.6e-05 22.8 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ORX74616.1 - 2e-10 40.5 3.3 2.2e-05 24.4 0.4 5.3 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX74616.1 - 3.5e-06 27.1 4.1 2 8.8 0.1 5.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ORX74616.1 - 0.0094 15.5 0.9 0.0094 15.5 0.9 5.1 5 1 0 5 5 5 1 Kelch motif F5_F8_type_C PF00754.25 ORX74616.1 - 0.13 12.4 0.0 0.54 10.4 0.0 2.0 1 1 0 1 1 1 0 F5/8 type C domain LSM PF01423.22 ORX74617.1 - 9.9e-09 34.8 0.2 9.4e-08 31.6 0.2 2.0 1 1 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX74617.1 - 0.0077 15.8 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Hfq protein Aminotran_5 PF00266.19 ORX74618.1 - 7.2e-45 153.5 0.0 8.7e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V PROCN PF08083.11 ORX74619.1 - 2e-222 738.2 4.3 3.4e-222 737.4 4.3 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ORX74619.1 - 9.4e-120 398.4 0.6 1.6e-119 397.6 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core PRO8NT PF08082.11 ORX74619.1 - 3.6e-86 286.7 2.8 8.5e-86 285.5 2.8 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U6-snRNA_bdg PF10596.9 ORX74619.1 - 4.9e-76 254.1 1.0 1.1e-75 252.9 1.0 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 ORX74619.1 - 2.6e-61 205.6 0.0 5.4e-61 204.5 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 ORX74619.1 - 5.4e-51 171.7 0.0 1.5e-50 170.2 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 ORX74619.1 - 8.8e-46 154.2 0.8 2.5e-45 152.8 0.8 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 ORX74619.1 - 0.00042 20.3 0.0 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Corona_5a PF06336.11 ORX74619.1 - 0.14 12.2 0.1 0.61 10.1 0.1 2.1 1 0 0 1 1 1 0 Coronavirus 5a protein SSXT PF05030.12 ORX74620.1 - 0.15 11.7 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 SSXT protein (N-terminal region) DUF1729 PF08354.10 ORX74621.1 - 1.4e-90 303.7 0.0 2.2e-90 303.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) SAT PF16073.5 ORX74621.1 - 2.1e-23 83.3 0.1 3.3e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_meander PF17951.1 ORX74621.1 - 8.6e-08 32.1 0.0 1.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydrat_N PF13452.6 ORX74621.1 - 2e-05 24.7 0.0 0.00017 21.7 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 ORX74621.1 - 0.045 13.3 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 MaoC like domain Fas_alpha_ACP PF18325.1 ORX74622.1 - 2e-50 171.3 0.0 3.3e-50 170.6 0.0 1.4 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 ORX74622.1 - 8.7e-40 136.5 0.1 2.9e-39 134.8 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 ORX74622.1 - 2.4e-24 86.3 1.5 3e-24 86.0 0.4 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX74622.1 - 7.9e-15 54.9 0.0 1.9e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain HR1 PF02185.16 ORX74622.1 - 0.084 13.0 0.5 0.36 11.0 0.1 2.2 2 0 0 2 2 2 0 Hr1 repeat Glyco_hydro_17 PF00332.18 ORX74622.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 Thiolase_N PF00108.23 ORX74622.1 - 0.15 11.4 0.1 0.35 10.2 0.1 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Ammonium_transp PF00909.21 ORX74623.1 - 9e-110 367.1 28.7 1e-109 366.9 28.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PgaD PF13994.6 ORX74623.1 - 4 7.5 8.3 0.2 11.7 1.1 2.4 3 0 0 3 3 3 0 PgaD-like protein Transcrip_reg PF01709.20 ORX74624.1 - 1.3e-84 283.4 1.9 1.5e-84 283.2 1.9 1.0 1 0 0 1 1 1 1 Transcriptional regulator GPI2 PF06432.11 ORX74626.1 - 1.7e-89 300.0 12.3 2.1e-89 299.7 12.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase YtpI PF14007.6 ORX74626.1 - 0.32 11.2 8.3 0.05 13.7 2.7 2.5 3 0 0 3 3 3 0 YtpI-like protein DUF5336 PF17270.2 ORX74626.1 - 1.4 8.5 5.7 2 8.1 3.7 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5336) DUF1576 PF07613.11 ORX74626.1 - 5.8 6.4 12.7 3 7.3 1.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1576) Pkinase PF00069.25 ORX74627.1 - 4.1e-66 223.0 0.0 5.1e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74627.1 - 1.7e-32 112.7 0.0 2.6e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX74627.1 - 0.022 14.1 0.1 0.088 12.2 0.0 2.0 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX74627.1 - 0.075 13.0 0.1 0.31 10.9 0.1 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX74627.1 - 0.075 12.0 0.0 0.11 11.5 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Ebp2 PF05890.12 ORX74627.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 Glutaredoxin PF00462.24 ORX74628.1 - 9.5e-14 51.4 0.0 1.4e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ORX74628.1 - 0.00032 21.0 0.0 0.00042 20.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain TraF PF13728.6 ORX74628.1 - 0.17 11.7 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein PNP_UDP_1 PF01048.20 ORX74629.1 - 2.4e-33 115.4 4.8 2.1e-31 109.0 4.8 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily zf-C3HC4_2 PF13923.6 ORX74630.1 - 4.7e-08 32.7 21.2 4.7e-08 32.7 21.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 ORX74630.1 - 4.8e-07 30.4 12.6 0.00014 22.5 3.9 3.7 2 2 1 3 3 2 2 TRAF-type zinc finger zf-C3HC4 PF00097.25 ORX74630.1 - 9.6e-07 28.6 18.0 4.3e-06 26.5 18.0 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.16 ORX74630.1 - 4.2e-05 23.6 8.4 0.073 13.0 0.4 2.5 1 1 1 2 2 2 2 Seven in absentia protein family zf-C3HC4_3 PF13920.6 ORX74630.1 - 9.2e-05 22.2 19.7 0.00046 20.0 19.7 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ORX74630.1 - 0.0001 22.1 11.3 0.0001 22.1 11.3 2.8 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 ORX74630.1 - 0.00036 20.8 22.4 0.00036 20.8 22.4 3.7 4 1 0 4 4 2 1 Ring finger domain zf-RING_10 PF16685.5 ORX74630.1 - 0.00038 20.5 16.4 0.0014 18.7 16.4 2.0 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 ORX74630.1 - 0.0006 19.8 16.6 0.003 17.5 16.6 2.3 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.15 ORX74630.1 - 0.0013 18.9 0.6 0.0044 17.2 0.0 2.1 2 1 0 2 2 2 1 U-box domain zf-RING_5 PF14634.6 ORX74630.1 - 0.0063 16.4 19.2 0.0063 16.4 19.2 2.9 2 0 0 2 2 2 1 zinc-RING finger domain Tropomyosin_1 PF12718.7 ORX74631.1 - 6.3e-21 75.0 32.5 8.8e-21 74.6 32.5 1.2 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 ORX74631.1 - 4.3e-07 29.5 33.4 1.8e-06 27.5 33.4 1.9 1 1 0 1 1 1 1 Tropomyosin Leu_zip PF15294.6 ORX74631.1 - 0.0064 16.0 25.3 0.015 14.9 6.6 2.0 1 1 1 2 2 2 2 Leucine zipper KASH_CCD PF14662.6 ORX74631.1 - 0.0078 16.1 30.9 0.049 13.5 10.2 2.0 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH Grg1 PF11034.8 ORX74631.1 - 0.011 15.9 4.1 1.1 9.6 0.2 2.5 2 0 0 2 2 2 0 Glucose-repressible protein Grg1 FlaC_arch PF05377.11 ORX74631.1 - 0.02 15.3 2.0 0.02 15.3 2.0 3.9 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 ORX74631.1 - 0.02 14.2 27.9 0.042 13.2 13.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CagE_TrbE_VirB PF03135.14 ORX74631.1 - 0.073 13.2 6.2 0.041 14.0 4.4 1.6 1 1 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system GAS PF13851.6 ORX74631.1 - 0.075 12.4 32.4 0.17 11.2 14.8 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding PI3K_P85_iSH2 PF16454.5 ORX74631.1 - 0.15 11.6 26.9 0.51 9.9 22.3 2.3 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Seryl_tRNA_N PF02403.22 ORX74631.1 - 0.17 12.2 27.6 1.3 9.3 17.7 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DHNA PF04038.12 ORX74631.1 - 0.17 12.4 2.3 0.28 11.7 0.4 2.1 1 1 1 2 2 2 0 Dihydroneopterin aldolase T3SSipB PF16535.5 ORX74631.1 - 0.2 12.1 17.5 0.37 11.3 10.6 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB Trimer_CC PF08954.11 ORX74631.1 - 0.2 11.2 12.8 2.2 7.9 1.2 3.8 3 1 0 3 3 3 0 Trimerisation motif LMWSLP_N PF12211.8 ORX74631.1 - 0.26 10.9 1.5 0.24 11.0 0.6 1.5 2 0 0 2 2 1 0 Low molecular weight S layer protein N terminal FliJ PF02050.16 ORX74631.1 - 0.27 11.5 29.8 0.2 11.9 20.9 2.1 1 1 1 2 2 2 0 Flagellar FliJ protein EzrA PF06160.12 ORX74631.1 - 0.27 9.3 28.7 0.024 12.9 10.5 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA HMMR_N PF15905.5 ORX74631.1 - 0.33 10.4 31.4 0.21 11.0 15.0 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Spectrin PF00435.21 ORX74631.1 - 0.35 11.4 25.9 2.4 8.7 15.9 2.2 1 1 1 2 2 2 0 Spectrin repeat CENP-F_leu_zip PF10473.9 ORX74631.1 - 0.81 9.7 34.5 3.7 7.6 16.1 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 ORX74631.1 - 0.85 9.3 28.5 7.4 6.3 28.5 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) YabA PF06156.13 ORX74631.1 - 1.1 9.9 24.4 0.078 13.6 6.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Fez1 PF06818.15 ORX74631.1 - 1.2 9.5 27.2 1.3 9.4 11.6 2.0 1 1 1 2 2 2 0 Fez1 HrpB7 PF09486.10 ORX74631.1 - 1.4 9.3 20.5 0.73 10.2 5.2 2.5 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) CTNNBL PF08216.11 ORX74631.1 - 1.4 9.1 11.6 0.076 13.2 4.4 2.3 1 1 1 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Exonuc_VII_L PF02601.15 ORX74631.1 - 1.9 8.0 15.3 2.3 7.7 15.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OEP PF02321.18 ORX74631.1 - 2 8.2 26.1 0.56 10.0 16.5 2.2 1 1 1 2 2 2 0 Outer membrane efflux protein Mod_r PF07200.13 ORX74631.1 - 2.1 8.4 30.1 2.5 8.2 9.4 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Jnk-SapK_ap_N PF09744.9 ORX74631.1 - 3.2 8.0 36.0 0.27 11.4 13.7 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 XhlA PF10779.9 ORX74631.1 - 4.3 7.6 25.3 2.1 8.6 0.5 4.5 1 1 2 4 4 4 0 Haemolysin XhlA Med9 PF07544.13 ORX74631.1 - 4.3 7.5 23.0 13 5.9 5.6 3.9 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Prefoldin_2 PF01920.20 ORX74631.1 - 4.6 7.3 34.6 24 4.9 2.9 4.5 1 1 2 3 3 3 0 Prefoldin subunit TPR_MLP1_2 PF07926.12 ORX74631.1 - 5.1 7.2 35.3 2.1 8.4 3.3 3.4 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF489 PF04356.12 ORX74631.1 - 5.6 6.9 9.3 3.2 7.7 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF489) BLOC1_2 PF10046.9 ORX74631.1 - 6 7.2 24.0 0.53 10.6 8.4 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rootletin PF15035.6 ORX74631.1 - 6.1 6.8 28.5 1.2 9.2 19.8 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TMF_DNA_bd PF12329.8 ORX74631.1 - 6.4 6.8 38.9 24 5.0 2.8 4.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding RecG_N PF17190.4 ORX74631.1 - 7.4 7.4 18.8 4.5 8.1 5.5 2.5 2 1 0 2 2 2 0 RecG N-terminal helical domain DUF2564 PF10819.8 ORX74631.1 - 7.6 7.0 15.0 7.2 7.1 7.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2564) DUF262 PF03235.14 ORX74631.1 - 7.7 6.6 14.3 9.9 6.3 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 ADIP PF11559.8 ORX74631.1 - 8.3 6.5 28.6 10 6.2 12.7 2.5 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 ORX74631.1 - 8.5 5.6 18.2 12 5.1 18.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ORX74631.1 - 9.2 6.4 20.7 2.3 8.4 5.9 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Med8 PF10232.9 ORX74632.1 - 2.9e-06 27.0 9.5 3.7e-06 26.7 9.5 1.3 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 FapA PF03961.13 ORX74632.1 - 0.061 11.9 1.2 0.07 11.7 1.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Gon7 PF08738.10 ORX74632.1 - 0.082 13.0 5.9 0.28 11.3 5.9 2.0 1 1 0 1 1 1 0 Gon7 family AMP-binding PF00501.28 ORX74633.1 - 1e-54 185.7 4.7 1e-16 60.6 0.2 5.0 3 2 0 4 4 4 4 AMP-binding enzyme DMAP_binding PF06464.11 ORX74633.1 - 6.2e-07 30.2 0.0 1.6e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 DMAP1-binding Domain BRI3BP PF14965.6 ORX74634.1 - 0.17 11.4 1.5 0.2 11.2 0.3 1.6 2 0 0 2 2 2 0 Negative regulator of p53/TP53 Pkinase PF00069.25 ORX74635.1 - 6.8e-72 242.0 0.0 9.2e-72 241.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74635.1 - 2.9e-35 121.8 0.0 4.5e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX74635.1 - 9.6e-14 51.8 3.8 2.2e-13 50.6 3.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 ORX74635.1 - 1.5e-05 24.1 0.0 2.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX74635.1 - 0.0002 20.8 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C2 PF00168.30 ORX74635.1 - 0.0012 19.1 0.0 0.0035 17.6 0.0 1.7 2 0 0 2 2 2 1 C2 domain APH PF01636.23 ORX74635.1 - 0.088 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ORX74635.1 - 0.092 12.4 0.0 18 4.9 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Lin-8 PF03353.15 ORX74635.1 - 1.5 8.3 4.6 3.1 7.3 4.6 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2591 PF10765.9 ORX74637.1 - 0.087 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) Rap_GAP PF02145.15 ORX74638.1 - 0.064 12.8 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Rap/ran-GAP MIF PF01187.18 ORX74639.1 - 5e-07 30.0 0.2 0.00012 22.3 0.1 2.0 1 1 1 2 2 2 2 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 ORX74639.1 - 0.16 11.9 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Tautomerase enzyme GDP_Man_Dehyd PF16363.5 ORX74640.1 - 6.4e-59 200.0 0.0 8.2e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX74640.1 - 6.6e-55 186.2 0.0 8e-55 185.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX74640.1 - 7.5e-17 61.2 0.0 9.4e-15 54.3 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ORX74640.1 - 2.7e-16 59.6 0.0 2.7e-15 56.3 0.0 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX74640.1 - 5.4e-13 48.7 0.0 7.9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ORX74640.1 - 6.3e-08 32.1 0.0 0.0012 18.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein KR PF08659.10 ORX74640.1 - 3.3e-05 23.9 0.0 6.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ORX74640.1 - 4.4e-05 23.4 0.0 0.00016 21.7 0.0 1.8 2 1 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 ORX74640.1 - 5.7e-05 22.7 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 ORX74640.1 - 0.013 15.0 0.0 0.044 13.3 0.0 1.9 2 1 0 2 2 2 0 NmrA-like family TrbE PF11100.8 ORX74641.1 - 0.078 13.2 0.7 0.15 12.3 0.7 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TrbE G2BR PF18442.1 ORX74642.1 - 0.0003 20.4 2.1 0.0005 19.6 2.1 1.3 1 0 0 1 1 1 1 E3 gp78 Ube2g2-binding region (G2BR) CUE PF02845.16 ORX74642.1 - 0.022 14.4 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 CUE domain HIT PF01230.23 ORX74643.1 - 5.7e-21 75.1 0.2 7e-21 74.8 0.2 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX74643.1 - 0.00013 22.4 0.4 0.00022 21.7 0.4 1.3 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX74643.1 - 0.00015 21.6 0.1 0.00023 21.0 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 HIT PF01230.23 ORX74644.1 - 6.3e-25 87.8 0.3 7.7e-25 87.5 0.3 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX74644.1 - 7e-10 39.4 0.0 9.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX74644.1 - 0.00029 20.7 0.1 0.00044 20.1 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DUF2992 PF11208.8 ORX74645.1 - 0.1 12.8 8.2 0.15 12.3 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Zip PF02535.22 ORX74645.1 - 0.52 9.5 3.7 0.6 9.3 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RRM_1 PF00076.22 ORX74646.1 - 2.5e-09 36.8 0.0 5.7e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 ORX74646.1 - 0.00012 22.3 0.0 0.00025 21.3 0.0 1.5 1 0 0 1 1 1 1 PWI domain COBRA1 PF06209.13 ORX74647.1 - 2.6e-26 92.6 0.2 7.2e-12 44.9 0.1 3.3 1 1 2 3 3 3 3 Cofactor of BRCA1 (COBRA1) CHDNT PF08073.12 ORX74647.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 CHDNT (NUC034) domain Sugar_tr PF00083.24 ORX74648.1 - 2.9e-48 164.9 16.2 6.5e-46 157.1 16.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX74648.1 - 4e-22 78.6 41.1 3.2e-21 75.7 24.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_transf_15 PF01793.16 ORX74651.1 - 1.4e-101 340.1 9.8 5.8e-101 338.0 9.8 1.7 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pyr_redox_2 PF07992.14 ORX74652.1 - 2.2e-50 171.6 0.1 2.6e-50 171.3 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX74652.1 - 5.5e-18 65.3 0.2 9.2e-16 58.2 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX74652.1 - 1.4e-16 60.6 0.0 3.3e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX74652.1 - 6.5e-05 22.2 0.2 0.021 13.9 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 ORX74652.1 - 7.3e-05 22.0 4.2 0.012 14.7 0.3 3.6 4 0 0 4 4 4 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 ORX74652.1 - 0.00017 21.1 0.3 0.0027 17.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX74652.1 - 0.00018 20.9 0.8 0.00056 19.2 0.1 2.1 2 1 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 ORX74652.1 - 0.0024 18.0 0.6 0.029 14.6 0.1 2.7 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ORX74652.1 - 0.011 14.4 0.9 0.072 11.8 1.4 2.1 2 0 0 2 2 2 0 HI0933-like protein K_oxygenase PF13434.6 ORX74652.1 - 0.012 14.8 0.1 1.4 8.0 0.0 2.8 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 ORX74652.1 - 0.083 13.3 0.0 0.85 10.1 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding DAO PF01266.24 ORX74652.1 - 0.086 12.4 2.2 1.5 8.3 2.2 2.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ORX74652.1 - 0.11 11.7 0.3 0.4 9.9 0.1 2.0 2 1 1 3 3 3 0 FAD binding domain FMO-like PF00743.19 ORX74652.1 - 0.12 10.7 0.0 0.33 9.3 0.0 1.6 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like Mito_carr PF00153.27 ORX74653.1 - 2.3e-67 222.9 6.4 3.8e-24 84.4 0.8 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Velvet PF11754.8 ORX74655.1 - 3.8e-46 158.1 1.6 1.1e-37 130.4 0.4 3.1 1 1 2 3 3 3 2 Velvet factor SelP_N PF04592.14 ORX74655.1 - 2.4 7.5 18.6 3.7 6.9 18.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 ORX74655.1 - 4.3 6.0 5.5 5.6 5.6 5.5 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 ORX74655.1 - 7.5 4.7 12.1 9.2 4.4 12.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF812 PF05667.11 ORX74655.1 - 9.2 5.0 6.7 0.86 8.4 2.5 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF1394 PF07159.12 ORX74657.1 - 7.2e-37 127.3 0.0 7.9e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) CRT10 PF08728.10 ORX74658.1 - 9.2e-07 27.4 0.9 0.029 12.5 0.1 4.1 2 2 1 3 3 3 3 CRT10 WD40 PF00400.32 ORX74658.1 - 0.024 15.5 0.7 0.16 12.9 0.1 2.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Pkinase PF00069.25 ORX74659.1 - 8.3e-72 241.7 0.0 1.2e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74659.1 - 1e-43 149.5 0.0 1.4e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX74659.1 - 4.2e-09 36.1 0.0 2.3e-06 27.1 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ORX74659.1 - 0.0012 17.7 1.2 0.0017 17.2 1.2 1.4 1 1 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX74659.1 - 0.0027 17.3 0.1 0.0046 16.5 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 ORX74659.1 - 0.009 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX74659.1 - 0.011 15.4 0.1 0.027 14.1 0.0 1.6 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX74659.1 - 0.013 15.5 0.1 0.031 14.2 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ORX74659.1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 MFS_1 PF07690.16 ORX74660.1 - 1.2e-09 37.6 23.2 1.4e-09 37.3 23.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5086 PF16985.5 ORX74660.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5086) Glyoxalase_4 PF13669.6 ORX74663.1 - 6.5e-19 68.2 0.0 7.7e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 ORX74663.1 - 7.6e-13 48.8 0.0 9e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ORX74663.1 - 1.2e-05 25.5 0.0 1.7e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ORX74663.1 - 0.0055 17.5 0.0 0.0079 17.0 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Fucose_iso_C PF02952.17 ORX74663.1 - 0.096 12.4 0.1 0.54 10.0 0.0 2.0 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain Nup84_Nup100 PF04121.13 ORX74663.1 - 0.13 10.3 0.0 0.19 9.8 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore protein 84 / 107 DUF1338 PF07063.13 ORX74663.1 - 0.14 11.3 0.1 1.9 7.6 0.0 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF1338) eIF-3c_N PF05470.12 ORX74664.1 - 1.4 7.2 7.1 1.7 6.9 7.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF4611 PF15387.6 ORX74664.1 - 3.7 7.8 12.6 4.8 7.5 2.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) WD40 PF00400.32 ORX74666.1 - 0.019 15.9 1.4 18 6.4 0.0 3.8 4 1 0 4 4 4 0 WD domain, G-beta repeat MgsA_C PF12002.8 ORX74667.1 - 7.9e-57 191.8 0.0 1.2e-56 191.2 0.0 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal RuvB_N PF05496.12 ORX74667.1 - 1.8e-15 57.1 0.0 3.5e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ORX74667.1 - 2.2e-15 57.3 0.0 3.6e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX74667.1 - 1.4e-09 38.1 0.0 3.6e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX74667.1 - 5.6e-07 29.4 0.0 0.00059 19.6 0.0 2.2 1 1 1 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 ORX74667.1 - 2.2e-06 27.2 0.0 0.025 13.9 0.0 3.0 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ORX74667.1 - 1.6e-05 25.4 0.0 0.066 13.6 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_assoc_2 PF16193.5 ORX74667.1 - 0.00012 22.4 0.6 0.11 12.9 0.1 2.7 1 1 1 2 2 2 2 AAA C-terminal domain AAA_2 PF07724.14 ORX74667.1 - 0.00025 21.2 0.0 0.00042 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 ORX74667.1 - 0.00042 20.3 0.0 0.00075 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX74667.1 - 0.0024 18.1 0.2 0.28 11.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 ORX74667.1 - 0.0028 17.8 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain NB-ARC PF00931.22 ORX74667.1 - 0.0029 16.8 0.1 0.078 12.2 0.0 2.2 1 1 1 2 2 2 1 NB-ARC domain AAA_3 PF07726.11 ORX74667.1 - 0.0036 17.2 0.0 0.018 14.9 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) zf_UBZ PF18439.1 ORX74667.1 - 0.0078 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger TIP49 PF06068.13 ORX74667.1 - 0.011 15.0 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain DNA_pol3_delta2 PF13177.6 ORX74667.1 - 0.02 14.7 0.0 1.6 8.5 0.0 2.2 1 1 1 2 2 2 0 DNA polymerase III, delta subunit ABC_tran PF00005.27 ORX74667.1 - 0.03 14.8 0.1 0.1 13.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 ORX74667.1 - 0.042 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 ORX74667.1 - 0.048 14.2 0.0 0.091 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ORX74667.1 - 0.052 12.7 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 ORX74667.1 - 0.097 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX74667.1 - 0.13 12.6 0.1 4.4 7.6 0.1 2.3 1 1 1 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 ORX74667.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 ORX74667.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ORX74667.1 - 0.15 11.9 0.1 0.44 10.4 0.1 1.6 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Peptidase_S10 PF00450.22 ORX74669.1 - 8.9e-56 190.1 0.0 1.3e-55 189.6 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase sCache_3_3 PF17202.4 ORX74669.1 - 0.18 12.2 0.0 0.33 11.4 0.0 1.4 1 0 0 1 1 1 0 Single cache domain 3 Allantoicase PF03561.15 ORX74670.1 - 5.4e-57 191.8 4.6 8.5e-37 126.3 0.1 4.2 3 1 1 4 4 4 4 Allantoicase repeat PaREP1 PF05942.11 ORX74670.1 - 0.0074 16.2 2.4 0.021 14.7 0.0 2.9 3 1 0 3 3 3 1 Archaeal PaREP1/PaREP8 family Barttin PF15462.6 ORX74670.1 - 0.48 10.2 6.8 0.25 11.1 4.1 2.1 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) 2-Hacid_dh_C PF02826.19 ORX74671.1 - 1.5e-40 138.5 0.0 4.2e-40 137.0 0.0 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX74671.1 - 8.9e-25 86.9 0.0 2.5e-24 85.5 0.0 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 ORX74671.1 - 4.2e-06 26.4 0.1 1.1e-05 25.1 0.1 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 ORX74671.1 - 0.11 13.1 2.8 0.41 11.3 1.7 2.2 2 0 0 2 2 2 0 ACT domain EnY2 PF10163.9 ORX74672.1 - 9.8e-25 86.7 0.4 1.1e-24 86.5 0.4 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF3618 PF12277.8 ORX74672.1 - 0.097 12.9 1.4 0.78 10.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3618) Methyltransf_31 PF13847.6 ORX74673.1 - 1.8e-17 63.5 0.0 2.4e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX74673.1 - 3.8e-12 46.7 0.0 1.5e-11 44.9 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX74673.1 - 3.9e-09 36.5 0.0 5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX74673.1 - 1.1e-08 35.6 0.1 3e-08 34.2 0.1 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74673.1 - 1.5e-08 35.3 0.1 3e-08 34.3 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX74673.1 - 7.6e-08 32.1 0.0 1.1e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX74673.1 - 9.7e-06 25.7 0.0 1.4e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX74673.1 - 0.00012 21.6 0.1 0.00016 21.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.11 ORX74673.1 - 0.00015 20.9 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase MetW PF07021.12 ORX74673.1 - 0.00029 20.5 0.1 0.0004 20.0 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 ORX74673.1 - 0.0048 17.2 0.1 0.0075 16.6 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase TPMT PF05724.11 ORX74673.1 - 0.0068 16.1 0.0 0.051 13.2 0.0 1.9 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 ORX74673.1 - 0.0076 15.6 0.0 0.014 14.7 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 ORX74673.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ORX74673.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 ORX74673.1 - 0.026 13.4 0.0 0.038 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Pox_MCEL PF03291.16 ORX74673.1 - 0.048 12.8 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme AviRa PF11599.8 ORX74673.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Aminotran_1_2 PF00155.21 ORX74674.1 - 5.8e-05 22.4 0.0 7.2e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_1_2 PF00155.21 ORX74675.1 - 2.7e-47 161.7 0.0 3.3e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX74675.1 - 0.00024 20.5 0.0 0.00034 20.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX74675.1 - 0.013 14.4 0.0 0.045 12.7 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class-V Aminotran_3 PF00202.21 ORX74675.1 - 0.026 13.2 0.0 0.046 12.4 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-III Cys_Met_Meta_PP PF01053.20 ORX74675.1 - 0.094 11.2 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX74675.1 - 0.11 11.8 0.0 0.4 9.9 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Rogdi_lz PF10259.9 ORX74676.1 - 3.3e-10 39.9 0.0 3.9e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein RRM_1 PF00076.22 ORX74678.1 - 1.5e-65 216.9 0.3 5.5e-15 54.9 0.0 5.8 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX74678.1 - 7.1e-07 28.9 0.0 0.1 12.2 0.0 4.3 4 1 1 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ORX74678.1 - 0.003 17.8 3.9 18 5.5 0.0 5.0 5 1 0 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 ORX74678.1 - 0.0033 17.5 0.0 5 7.3 0.0 4.2 4 0 0 4 4 4 1 RNA recognition motif Smg4_UPF3 PF03467.15 ORX74678.1 - 0.0096 16.0 0.4 7.9 6.5 0.0 3.4 3 0 0 3 3 3 2 Smg-4/UPF3 family RRM_Rrp7 PF17799.1 ORX74678.1 - 0.15 11.9 0.0 1.5 8.6 0.0 2.6 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 ORX74679.1 - 2.6e-36 123.3 0.0 2.7e-16 59.1 0.0 5.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX74679.1 - 0.0012 18.5 0.0 0.0046 16.6 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX74679.1 - 0.077 13.1 0.0 11 6.2 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif Ribosomal_L44 PF00935.19 ORX74680.1 - 7.2e-37 125.7 11.0 9.6e-37 125.3 11.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Cathelicidins PF00666.17 ORX74680.1 - 0.049 13.9 0.8 0.073 13.4 0.8 1.2 1 0 0 1 1 1 0 Cathelicidin LRV_FeS PF05484.11 ORX74680.1 - 0.34 10.9 2.4 0.38 10.8 0.4 1.9 2 0 0 2 2 2 0 LRV protein FeS4 cluster ORC2 PF04084.14 ORX74681.1 - 2.3e-104 348.9 0.0 2.9e-104 348.6 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Cwf_Cwc_15 PF04889.12 ORX74681.1 - 0.53 10.0 9.2 0.85 9.3 9.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 ORX74681.1 - 1.1 8.7 9.1 1.5 8.1 9.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ORX74681.1 - 2.6 6.2 12.5 3.2 5.8 12.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 ORX74681.1 - 6.3 5.8 14.8 8.3 5.4 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PPP4R2 PF09184.11 ORX74681.1 - 8.2 5.9 8.0 13 5.3 8.0 1.2 1 0 0 1 1 1 0 PPP4R2 Transferase PF02458.15 ORX74682.1 - 4e-05 22.5 0.1 5.9e-05 21.9 0.1 1.4 1 1 1 2 2 2 1 Transferase family Herpes_UL51 PF04540.13 ORX74682.1 - 0.056 13.2 0.0 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL51 protein Alg6_Alg8 PF03155.15 ORX74683.1 - 3.2e-114 382.6 29.3 1.7e-113 380.2 29.3 1.8 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PBD PF00786.28 ORX74683.1 - 0.2 12.1 0.0 0.39 11.1 0.0 1.4 1 0 0 1 1 1 0 P21-Rho-binding domain Ribosomal_L1 PF00687.21 ORX74684.1 - 1.9e-44 151.9 0.2 4e-44 150.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PI3K_1B_p101 PF10486.9 ORX74684.1 - 0.088 10.6 1.9 0.12 10.2 1.9 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF792 PF05632.11 ORX74684.1 - 0.16 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) SLAIN PF15301.6 ORX74684.1 - 0.28 10.4 5.9 0.051 12.8 2.0 1.7 2 0 0 2 2 2 0 SLAIN motif-containing family PTRF_SDPR PF15237.6 ORX74684.1 - 0.57 9.8 6.9 0.12 11.9 3.4 1.7 2 0 0 2 2 2 0 PTRF/SDPR family FmiP_Thoc5 PF09766.9 ORX74684.1 - 0.85 8.8 7.8 0.24 10.6 4.8 1.5 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 eIF_4EBP PF05456.11 ORX74684.1 - 1.1 9.2 0.0 1.1 9.2 0.0 3.2 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) TRAP_alpha PF03896.16 ORX74684.1 - 1.3 8.2 5.8 2.5 7.2 5.8 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 ORX74684.1 - 1.4 8.2 10.6 2.2 7.5 10.6 1.3 1 0 0 1 1 1 0 NOA36 protein TLP-20 PF06088.11 ORX74684.1 - 2.9 7.7 6.3 0.55 10.1 2.7 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FAM176 PF14851.6 ORX74684.1 - 3.1 7.5 8.3 0.55 9.9 4.1 1.9 2 0 0 2 2 2 0 FAM176 family DUF4746 PF15928.5 ORX74684.1 - 3.5 7.0 11.1 0.92 8.9 8.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DDHD PF02862.17 ORX74684.1 - 4.1 7.5 5.9 0.74 9.9 2.1 1.7 2 0 0 2 2 2 0 DDHD domain PBP1_TM PF14812.6 ORX74684.1 - 5 7.6 13.7 5.7 7.4 11.7 2.2 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ORX74684.1 - 5.7 4.9 12.6 8.5 4.3 12.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi LSM PF01423.22 ORX74685.1 - 6.7e-17 61.0 0.0 3.4e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 LSM domain SM-ATX PF14438.6 ORX74685.1 - 4e-05 23.7 0.0 5.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain FoP_duplication PF13865.6 ORX74685.1 - 3.1 8.4 16.8 4.9 7.8 16.8 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Hexapep PF00132.24 ORX74686.1 - 0.0018 17.9 13.8 0.015 15.0 0.5 3.8 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ORX74686.1 - 4.3 7.2 10.3 11 5.8 0.1 2.9 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Fis1_TPR_C PF14853.6 ORX74687.1 - 3.3e-23 81.5 0.5 5.3e-23 80.8 0.5 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 ORX74687.1 - 1.1e-13 50.6 0.0 1.7e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 ORX74687.1 - 0.00045 20.1 1.4 0.001 19.0 1.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat COPI_C PF06957.11 ORX74687.1 - 0.024 13.4 0.0 0.032 13.0 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus TPR_6 PF13174.6 ORX74687.1 - 0.031 14.9 0.3 0.56 11.0 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX74687.1 - 0.037 13.9 1.7 0.067 13.0 1.7 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX74687.1 - 0.061 13.9 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX74687.1 - 0.093 13.0 0.2 0.14 12.4 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX74687.1 - 0.11 12.6 0.3 0.29 11.3 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX74687.1 - 0.14 12.0 0.6 0.14 12.0 0.6 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Pet100 PF09803.9 ORX74689.1 - 8.7e-17 61.4 0.6 9.9e-17 61.2 0.6 1.1 1 0 0 1 1 1 1 Pet100 Cation_efflux PF01545.21 ORX74690.1 - 3.3e-10 40.0 2.5 4.6e-10 39.5 2.5 1.1 1 0 0 1 1 1 1 Cation efflux family HAD PF12710.7 ORX74691.1 - 4.4e-09 37.0 0.2 6.6e-09 36.4 0.2 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ORX74691.1 - 0.0019 17.7 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 ORX74691.1 - 0.021 14.3 0.4 7.3 5.9 0.0 2.9 2 1 0 2 2 2 0 Putative Phosphatase zf-RING_2 PF13639.6 ORX74692.1 - 8.4e-16 58.0 6.7 1.2e-15 57.6 6.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX74692.1 - 4.6e-11 42.3 3.9 4.6e-11 42.3 3.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX74692.1 - 6.2e-11 42.0 6.2 9.2e-11 41.4 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX74692.1 - 5.8e-10 39.3 7.8 1.2e-09 38.3 7.8 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX74692.1 - 3.6e-09 36.3 6.9 5.4e-09 35.8 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX74692.1 - 1.6e-08 34.2 4.0 2.1e-08 33.9 4.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX74692.1 - 1.9e-08 34.2 1.5 1.9e-08 34.2 1.5 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX74692.1 - 2.2e-08 33.9 5.0 3e-08 33.5 5.0 1.2 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX74692.1 - 7.5e-07 28.9 4.7 1.4e-06 28.1 4.7 1.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX74692.1 - 2.8e-05 24.1 4.9 0.0001 22.2 4.9 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX74692.1 - 0.00023 20.7 4.0 0.0003 20.3 4.0 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX74692.1 - 0.00024 21.2 4.8 0.00054 20.0 4.8 1.6 1 1 0 1 1 1 1 RING-variant domain zf-RING-like PF08746.11 ORX74692.1 - 0.0079 16.5 6.3 0.012 16.0 6.3 1.3 1 0 0 1 1 1 1 RING-like domain zf-RING_4 PF14570.6 ORX74692.1 - 0.048 13.5 4.9 0.12 12.2 4.9 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ORX74692.1 - 0.081 12.8 1.5 0.12 12.3 1.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 ORX74692.1 - 0.089 12.6 1.9 0.26 11.2 1.6 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 ORX74692.1 - 0.21 11.8 10.1 6.1 7.1 10.1 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 ORX74692.1 - 0.44 10.5 9.1 0.92 9.5 6.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 ORX74692.1 - 0.5 10.6 4.9 3.3 7.9 5.2 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING PHD PF00628.29 ORX74692.1 - 0.5 10.3 7.1 1.2 9.1 7.1 1.7 1 1 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.5 ORX74692.1 - 0.64 10.1 7.3 1.8 8.7 7.3 1.8 1 1 0 1 1 1 0 Zinc-finger RecR PF02132.15 ORX74692.1 - 1.6 8.4 5.6 5.3 6.7 0.2 2.6 2 0 0 2 2 2 0 RecR protein WD40 PF00400.32 ORX74693.1 - 5.6e-27 93.4 14.5 8.3e-07 29.6 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74693.1 - 7.7e-16 58.2 0.2 1.6e-05 25.1 0.1 4.5 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 ORX74693.1 - 0.013 14.4 0.5 0.038 12.9 0.4 1.8 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 ORX74693.1 - 0.033 13.2 0.0 0.23 10.4 0.0 2.3 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein OTU PF02338.19 ORX74694.1 - 1.6e-13 51.3 0.0 2.2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ORX74694.1 - 9.1e-08 31.8 0.1 0.00058 19.4 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain Peptidase_M28 PF04389.17 ORX74695.1 - 9e-22 77.7 0.1 1.3e-21 77.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX74695.1 - 1.1e-06 28.5 0.0 2.1e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PA PF02225.22 ORX74695.1 - 0.0063 16.5 0.7 0.015 15.3 0.2 1.9 2 0 0 2 2 2 1 PA domain CK_II_beta PF01214.18 ORX74696.1 - 5.6e-81 270.7 0.0 6.8e-81 270.4 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Glyco_transf_15 PF01793.16 ORX74697.1 - 2.7e-105 352.2 2.2 3.5e-105 351.8 2.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Phage_lysozyme PF00959.19 ORX74698.1 - 5.1e-11 43.0 0.0 1.1e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 ORX74698.1 - 0.0078 16.5 0.0 0.026 14.8 0.0 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain zf-RING-like PF08746.11 ORX74698.1 - 0.033 14.5 0.1 0.08 13.3 0.1 1.6 1 0 0 1 1 1 0 RING-like domain Glyco_hydro_18 PF00704.28 ORX74699.1 - 4.1e-52 177.8 0.1 6.2e-52 177.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 ORX74699.1 - 1.1e-10 41.9 15.1 2e-10 40.9 15.1 1.5 1 0 0 1 1 1 1 Chitin recognition protein DUF4090 PF13319.6 ORX74700.1 - 0.14 12.4 0.3 4.9 7.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4090) KxDL PF10241.9 ORX74700.1 - 1.4 9.3 3.6 17 5.7 0.6 3.4 3 0 0 3 3 3 0 Uncharacterized conserved protein HMG_box PF00505.19 ORX74701.1 - 1.9e-17 63.4 0.4 4.1e-17 62.3 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX74701.1 - 5.8e-12 46.0 0.7 1.4e-11 44.8 0.7 1.7 1 0 0 1 1 1 1 HMG-box domain GCV_T PF01571.21 ORX74702.1 - 1.1e-11 44.7 0.0 1.7e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain mRNA_triPase PF02940.15 ORX74706.1 - 1.1e-49 169.1 0.7 1.4e-49 168.7 0.7 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain AdoHcyase PF05221.17 ORX74707.1 - 3.6e-136 453.2 0.0 9.6e-75 251.5 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ORX74707.1 - 8.8e-72 240.5 3.1 1.5e-71 239.7 3.1 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 ORX74707.1 - 0.00065 19.1 0.3 0.0013 18.1 0.3 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain End3 PF12761.7 ORX74708.1 - 1.9e-13 51.1 13.0 1.6e-12 48.0 13.0 2.2 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 ORX74708.1 - 3.2e-12 46.3 0.0 2.1e-07 30.8 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand APG6_N PF17675.1 ORX74708.1 - 2.4 8.7 23.1 13 6.4 17.0 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region FapA PF03961.13 ORX74708.1 - 7.7 5.0 10.2 20 3.6 10.2 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF2612 PF11041.8 ORX74709.1 - 0.048 13.6 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2612) Kri1 PF05178.12 ORX74713.1 - 5.1e-17 62.3 11.5 5.1e-17 62.3 11.5 6.2 2 2 3 5 5 5 1 KRI1-like family Kri1_C PF12936.7 ORX74713.1 - 1.2e-06 28.5 25.6 1.2e-06 28.5 25.6 5.8 4 1 0 4 4 4 1 KRI1-like family C-terminal L51_S25_CI-B8 PF05047.16 ORX74714.1 - 1.1e-08 34.8 0.1 3.3e-08 33.3 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF3960 PF13142.6 ORX74714.1 - 0.032 14.4 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3960) Rad50_zn_hook PF04423.14 ORX74715.1 - 0.11 12.3 0.1 0.42 10.5 0.0 1.9 2 0 0 2 2 2 0 Rad50 zinc hook motif Glyco_hydro_61 PF03443.14 ORX74718.1 - 1.4e-58 198.2 0.0 2.2e-58 197.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SSURE PF11966.8 ORX74718.1 - 0.22 11.3 2.6 0.26 11.1 0.0 2.3 3 0 0 3 3 3 0 Fibronectin-binding repeat Pec_lyase_C PF00544.19 ORX74719.1 - 8e-09 35.4 8.7 2.2e-07 30.7 8.7 2.4 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 ORX74719.1 - 2.5e-05 24.2 14.6 0.00028 20.8 13.1 2.2 1 1 1 2 2 2 2 Right handed beta helix region Transferase PF02458.15 ORX74720.1 - 7.4e-25 87.5 0.0 4.4e-16 58.6 0.0 2.1 2 0 0 2 2 2 2 Transferase family RBDV_coat PF06593.11 ORX74720.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Raspberry bushy dwarf virus coat protein Meth_synt_2 PF01717.18 ORX74721.1 - 1.9e-144 480.9 0.0 2e-143 477.5 0.0 2.1 2 0 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ORX74721.1 - 1.8e-85 287.2 0.4 1.2e-73 248.4 0.0 4.3 3 1 1 4 4 4 4 Cobalamin-independent synthase, N-terminal domain TraC PF07820.12 ORX74721.1 - 0.03 14.6 1.1 0.11 12.8 0.9 2.0 2 0 0 2 2 2 0 TraC-like protein TFR_dimer PF04253.15 ORX74722.1 - 3.4e-16 59.5 0.0 5.6e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 ORX74722.1 - 4.4e-13 49.1 1.9 6e-13 48.6 0.1 2.2 2 0 0 2 2 2 1 PA domain Peptidase_M28 PF04389.17 ORX74722.1 - 3.3e-09 36.7 0.4 6.7e-09 35.7 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M28 LRV PF01816.17 ORX74722.1 - 0.81 10.2 5.8 2.4 8.8 1.9 3.4 2 0 0 2 2 2 0 Leucine rich repeat variant Nrap_D4 PF17405.2 ORX74723.1 - 4.2e-34 117.8 0.1 1.3e-33 116.2 0.1 1.8 1 1 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D6 PF17407.2 ORX74723.1 - 7.1e-34 116.9 0.0 1.5e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap PF03813.14 ORX74723.1 - 4.2e-29 101.6 0.0 7.2e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D5 PF17406.2 ORX74723.1 - 1.1e-24 87.0 0.0 4.4e-24 85.1 0.0 2.1 1 1 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 ORX74723.1 - 8.2e-16 58.5 0.0 3.2e-15 56.6 0.0 2.1 1 1 0 1 1 1 1 Nrap protein domain 3 Glyco_hydro_46 PF01374.18 ORX74725.1 - 5.3e-25 88.3 3.4 8.5e-22 77.8 0.5 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 46 WD40 PF00400.32 ORX74726.1 - 1.8e-35 120.3 17.4 2e-05 25.2 0.8 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74726.1 - 1.1e-14 54.4 0.2 0.003 17.8 0.0 4.2 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX74726.1 - 0.00036 20.5 0.0 0.072 13.0 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ORX74726.1 - 0.0016 17.8 0.0 0.03 13.6 0.0 2.4 2 1 0 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 ORX74726.1 - 0.028 13.4 0.3 6.4 5.6 0.0 3.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Uds1 PF15456.6 ORX74726.1 - 0.16 12.2 0.7 0.28 11.4 0.7 1.3 1 0 0 1 1 1 0 Up-regulated During Septation Acyl-CoA_dh_1 PF00441.24 ORX74727.1 - 1.4e-25 90.2 0.6 2.7e-25 89.3 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX74727.1 - 2.6e-23 82.0 0.0 5.1e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX74727.1 - 6.2e-11 43.0 0.4 1.4e-10 41.8 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX74727.1 - 5.3e-07 30.0 0.2 1e-06 29.1 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ORX74727.1 - 3.1e-05 23.8 0.2 5.9e-05 22.9 0.2 1.4 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Ribosomal_S3Ae PF01015.18 ORX74729.1 - 6.2e-79 264.3 2.8 8.4e-79 263.8 2.8 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family DUF2213 PF09979.9 ORX74729.1 - 0.13 12.3 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2213) SH3_1 PF00018.28 ORX74730.1 - 1.2e-09 37.6 0.1 1.8e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX74730.1 - 6.5e-08 32.3 0.0 1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX74730.1 - 6.8e-07 28.9 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_4 PF06347.13 ORX74730.1 - 0.036 13.9 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_10 PF17902.1 ORX74730.1 - 0.04 14.0 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 SH3 domain DUF2878 PF11086.8 ORX74730.1 - 0.3 11.3 11.9 0.61 10.3 11.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2878) PhoD PF09423.10 ORX74731.1 - 1.3e-25 90.2 8.6 3.1e-15 56.0 5.2 2.8 1 1 1 2 2 2 2 PhoD-like phosphatase DUF2418 PF10332.9 ORX74732.1 - 8.2e-23 80.8 1.7 8.4e-23 80.7 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) zf-C2H2_2 PF12756.7 ORX74733.1 - 0.16 12.3 6.0 4.2 7.8 0.1 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CS PF04969.16 ORX74734.1 - 5.4e-08 33.7 0.0 1.1e-07 32.8 0.0 1.5 1 0 0 1 1 1 1 CS domain BUD22 PF09073.10 ORX74735.1 - 1e-36 127.2 64.3 1.7e-15 57.3 19.4 4.8 3 1 1 4 4 4 3 BUD22 zf-MIZ PF02891.20 ORX74736.1 - 6.9e-22 76.9 2.2 1.2e-21 76.1 2.2 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger PINIT PF14324.6 ORX74736.1 - 9.5e-18 64.9 0.3 1.5e-17 64.3 0.3 1.3 1 0 0 1 1 1 1 PINIT domain zf-Nse PF11789.8 ORX74736.1 - 4.4e-10 39.2 0.2 8.1e-10 38.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ORX74736.1 - 0.039 13.8 3.0 0.087 12.7 3.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX74736.1 - 0.22 11.9 2.3 0.48 10.8 2.3 1.6 1 0 0 1 1 1 0 Ring finger domain 2OG-FeII_Oxy_2 PF13532.6 ORX74738.1 - 3.6e-07 30.6 0.0 1.7e-05 25.1 0.0 2.1 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily eIF-5a PF01287.20 ORX74739.1 - 8.1e-25 86.7 0.1 1.1e-24 86.3 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 ORX74739.1 - 8.3e-05 22.5 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain F-box-like PF12937.7 ORX74740.1 - 0.014 15.3 0.1 0.033 14.1 0.1 1.7 1 0 0 1 1 1 0 F-box-like Inositol_P PF00459.25 ORX74741.1 - 2.4e-39 135.5 0.6 3.9e-22 79.1 0.1 2.1 2 0 0 2 2 2 2 Inositol monophosphatase family Methyltransf_23 PF13489.6 ORX74742.1 - 1.1e-05 25.4 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX74742.1 - 8.1e-05 23.3 0.0 0.00013 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX74742.1 - 0.00071 19.4 0.0 0.00098 18.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX74742.1 - 0.0071 15.7 0.0 0.01 15.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX74742.1 - 0.025 15.2 0.0 0.042 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ORX74742.1 - 0.11 13.2 0.0 0.28 11.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Clathrin PF00637.20 ORX74743.1 - 3.7e-07 30.1 4.2 1.1e-06 28.6 0.3 3.2 2 1 1 3 3 3 1 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 ORX74743.1 - 2.4e-06 27.4 6.9 4.4e-06 26.6 6.9 1.5 1 0 0 1 1 1 1 Zinc-finger VPS11_C PF12451.8 ORX74743.1 - 9.4e-06 25.8 0.5 1.9e-05 24.8 0.5 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-RING_5 PF14634.6 ORX74743.1 - 0.0092 15.9 7.0 0.019 14.9 7.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX74743.1 - 0.019 14.8 8.3 0.039 13.8 8.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX74743.1 - 0.019 15.0 4.2 0.057 13.5 4.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 ORX74743.1 - 0.051 13.9 7.6 0.11 12.9 7.6 1.6 1 0 0 1 1 1 0 Ring finger domain zf-ANAPC11 PF12861.7 ORX74743.1 - 0.49 10.5 2.2 1.1 9.3 2.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ORX74743.1 - 0.78 10.1 5.7 2.3 8.6 5.6 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ORX74743.1 - 3.3 7.5 5.2 8.1 6.3 5.2 1.7 1 0 0 1 1 1 0 RING-like zinc finger ETF PF01012.21 ORX74744.1 - 8.4e-28 97.5 15.8 9e-28 97.4 15.0 1.4 1 1 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ORX74744.1 - 9.9e-27 92.8 2.7 9.9e-27 92.8 2.7 2.4 2 1 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain DUF1840 PF08895.11 ORX74744.1 - 0.45 10.9 2.3 0.95 9.8 2.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) HgmA PF04209.13 ORX74745.1 - 1.1e-181 604.2 3.0 2.9e-180 599.5 3.0 2.1 1 1 0 1 1 1 1 homogentisate 1,2-dioxygenase DGCR6 PF07324.11 ORX74746.1 - 3e-05 23.7 4.8 0.00014 21.6 4.8 1.9 1 1 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF2458 PF10454.9 ORX74746.1 - 5.8e-05 22.8 5.4 8.7e-05 22.2 5.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Rz1 PF06085.11 ORX74746.1 - 0.48 10.2 8.8 5.6 6.8 2.6 2.8 2 1 0 2 2 2 0 Lipoprotein Rz1 precursor PTPLA PF04387.14 ORX74747.1 - 9e-48 162.1 6.1 9e-48 162.1 6.1 1.6 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA ESCRT-II PF05871.12 ORX74748.1 - 1.7e-47 161.2 0.1 2.1e-47 160.9 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit Glyco_hydro_63 PF03200.16 ORX74749.1 - 4.3e-154 513.9 0.0 5.1e-154 513.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 ORX74749.1 - 2.3e-56 191.4 0.0 3.8e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain AhpC-TSA PF00578.21 ORX74750.1 - 1.2e-31 109.2 0.0 1.5e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX74750.1 - 4e-13 49.3 0.0 5.9e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ORX74750.1 - 1.5e-10 40.7 0.2 2.6e-10 40.0 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Peptidase_C12 PF01088.21 ORX74751.1 - 2.1e-61 207.4 0.0 2.3e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF5102 PF17104.5 ORX74752.1 - 0.0023 18.1 19.1 0.019 15.0 1.5 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF5102) DUF4423 PF14394.6 ORX74752.1 - 0.071 12.8 0.1 2.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) SF3A2 PF16835.5 ORX74753.1 - 2.9e-40 136.6 0.2 5.6e-40 135.6 0.2 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 ORX74753.1 - 4.4e-07 30.1 2.0 4.4e-07 30.1 2.0 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 ORX74753.1 - 3.1e-05 23.9 0.6 5.2e-05 23.2 0.6 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 ORX74753.1 - 0.059 12.9 0.6 0.1 12.2 0.6 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like TACC_C PF05010.14 ORX74754.1 - 0.0051 16.6 0.0 0.17 11.6 0.1 2.1 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal CCDC84 PF14968.6 ORX74754.1 - 0.048 13.3 0.1 0.071 12.7 0.1 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 DUF4888 PF16229.5 ORX74754.1 - 0.2 11.6 1.1 1.7 8.6 1.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4888) OGG_N PF07934.12 ORX74756.1 - 1.4e-25 89.7 0.0 2.5e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 ORX74756.1 - 2.1e-09 37.8 0.0 4.5e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ORX74756.1 - 0.025 14.4 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif PLDc_2 PF13091.6 ORX74757.1 - 1.8e-10 40.8 0.0 2.7e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ORX74757.1 - 0.0013 18.8 0.1 1.6 9.1 0.0 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Skp1 PF01466.19 ORX74758.1 - 6e-27 93.5 0.2 1.1e-26 92.6 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ORX74758.1 - 2e-26 91.9 0.3 2e-26 91.9 0.3 2.2 4 0 0 4 4 4 1 Skp1 family, tetramerisation domain Trypan_PARP PF05887.11 ORX74759.1 - 0.83 9.6 17.8 1.4 8.9 17.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3533 PF12051.8 ORX74760.1 - 2.6e-27 95.7 10.7 6.8e-20 71.3 11.6 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3533) DUF4246 PF14033.6 ORX74761.1 - 3.6e-133 445.0 0.0 4.3e-133 444.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ORX74761.1 - 0.17 12.3 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase cNMP_binding PF00027.29 ORX74762.1 - 1.6e-32 111.4 0.5 4.6e-16 58.7 0.0 5.0 4 1 0 4 4 4 4 Cyclic nucleotide-binding domain Patatin PF01734.22 ORX74762.1 - 1.3e-18 67.9 3.8 1.6e-17 64.3 3.8 2.7 1 1 0 1 1 1 1 Patatin-like phospholipase Rep_fac_C PF08542.11 ORX74763.1 - 6.4e-24 84.2 0.0 2.2e-23 82.5 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 ORX74763.1 - 6.7e-12 45.5 0.0 2.9e-09 36.9 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 ORX74763.1 - 2.2e-11 44.3 0.0 3.9e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX74763.1 - 1.9e-06 28.0 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX74763.1 - 3.1e-06 27.7 0.0 0.00071 20.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX74763.1 - 9e-06 26.0 0.1 0.007 16.6 0.1 2.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX74763.1 - 1.2e-05 24.8 0.1 0.00032 20.1 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX74763.1 - 5.1e-05 23.3 0.0 9.9e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 ORX74763.1 - 0.00015 21.6 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 ORX74763.1 - 0.00028 20.8 0.0 0.0011 18.9 0.0 1.9 2 1 0 2 2 2 1 Rad17 P-loop domain TniB PF05621.11 ORX74763.1 - 0.0005 19.5 0.0 0.51 9.7 0.0 2.3 2 0 0 2 2 2 2 Bacterial TniB protein AAA_19 PF13245.6 ORX74763.1 - 0.0012 19.1 0.2 0.0054 17.1 0.2 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ORX74763.1 - 0.0019 18.0 0.0 0.0042 16.8 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 ORX74763.1 - 0.0024 17.7 0.0 0.004 17.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 ORX74763.1 - 0.003 16.6 0.1 0.0082 15.2 0.1 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 ORX74763.1 - 0.0042 16.7 0.1 0.012 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX74763.1 - 0.0054 16.5 0.0 0.0094 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 ORX74763.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 ATPase MipZ AAA_assoc_2 PF16193.5 ORX74763.1 - 0.02 15.2 0.0 0.053 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain NTPase_1 PF03266.15 ORX74763.1 - 0.045 13.7 0.5 0.13 12.1 0.2 1.9 1 1 0 2 2 2 0 NTPase RsgA_GTPase PF03193.16 ORX74763.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 ORX74763.1 - 0.081 13.2 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ORX74763.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Auto_anti-p27 PF06677.12 ORX74764.1 - 7.6e-24 83.6 8.3 2.6e-12 46.7 1.6 2.2 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NPV_P10 PF05531.12 ORX74764.1 - 0.053 14.0 0.3 0.11 13.0 0.3 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein She9_MDM33 PF05546.11 ORX74764.1 - 0.081 12.7 1.1 0.097 12.5 0.0 1.6 2 0 0 2 2 2 0 She9 / Mdm33 family CBP_BcsR PF10945.8 ORX74764.1 - 0.15 11.6 0.1 0.73 9.4 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsR CHORD PF04968.12 ORX74764.1 - 2 9.2 4.3 0.68 10.7 0.3 2.1 2 0 0 2 2 2 0 CHORD Arf PF00025.21 ORX74765.1 - 2.4e-41 141.1 0.1 3.1e-41 140.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ORX74765.1 - 4e-09 36.3 0.0 5.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ORX74765.1 - 7.7e-09 35.2 0.0 0.0028 16.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ORX74765.1 - 1.4e-08 34.9 0.0 2.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ORX74765.1 - 7.9e-07 28.7 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX74765.1 - 5.6e-06 25.9 0.0 7.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX74765.1 - 2e-05 24.7 0.0 3.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX74765.1 - 8.9e-05 22.1 0.3 0.0021 17.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 ORX74765.1 - 0.00023 21.1 0.2 0.15 12.0 0.0 2.1 2 0 0 2 2 2 2 NACHT domain AAA_16 PF13191.6 ORX74765.1 - 0.0012 19.2 0.0 0.62 10.4 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX74765.1 - 0.006 16.5 0.0 2.4 8.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase AAA_5 PF07728.14 ORX74765.1 - 0.0078 16.2 0.6 0.12 12.3 0.6 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX74765.1 - 0.0092 16.3 0.1 0.019 15.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX74765.1 - 0.01 16.4 0.0 0.017 15.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ORX74765.1 - 0.02 14.5 0.1 0.061 12.9 0.1 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ORX74765.1 - 0.027 14.6 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NOG1 PF06858.14 ORX74765.1 - 0.045 13.5 0.0 0.74 9.6 0.0 2.4 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) ABC_tran PF00005.27 ORX74765.1 - 0.084 13.4 0.1 0.18 12.3 0.1 1.4 1 1 0 1 1 1 0 ABC transporter Thymidylate_kin PF02223.17 ORX74765.1 - 0.086 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase AAA_17 PF13207.6 ORX74765.1 - 0.096 13.1 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX74765.1 - 0.1 12.1 0.2 0.7 9.5 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ORX74765.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ORX74765.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CARD_2 PF16739.5 ORX74765.1 - 0.16 12.0 0.0 0.67 10.0 0.0 1.9 2 0 0 2 2 2 0 Caspase recruitment domain Vfa1 PF08432.10 ORX74766.1 - 0.061 13.7 0.6 0.066 13.5 0.6 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SPX PF03105.19 ORX74769.1 - 2e-34 120.2 0.1 1e-22 81.7 0.0 2.2 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 ORX74769.1 - 2.3e-32 112.7 33.7 2.8e-32 112.4 33.7 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX74769.1 - 1.9e-25 89.7 39.9 5.6e-19 68.5 16.7 2.2 1 1 1 2 2 2 2 Citrate transporter DUF4717 PF15838.5 ORX74769.1 - 0.086 12.9 0.2 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4717) Methyltransf_16 PF10294.9 ORX74770.1 - 6.1e-38 130.3 0.0 7.9e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ORX74770.1 - 0.00052 19.6 0.0 0.0007 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX74770.1 - 0.004 17.0 0.0 0.0053 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 ORX74770.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_31 PF13847.6 ORX74770.1 - 0.027 14.3 0.0 0.046 13.5 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ORX74770.1 - 0.062 12.7 0.1 0.087 12.2 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PfkB PF00294.24 ORX74772.1 - 5.6e-16 58.7 0.7 1.7e-15 57.1 0.7 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase LPD14 PF18827.1 ORX74772.1 - 0.008 16.5 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Large polyvalent protein-associated domain 14 adh_short PF00106.25 ORX74773.1 - 1.2e-43 148.9 0.3 1.6e-43 148.4 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX74773.1 - 1.5e-29 103.2 0.1 2.1e-29 102.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX74773.1 - 7.8e-15 55.2 0.8 1.1e-14 54.7 0.8 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ORX74773.1 - 0.00088 18.6 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ORX74773.1 - 0.0016 18.0 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ORX74773.1 - 0.0018 18.2 0.4 0.0031 17.4 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ORX74773.1 - 0.0023 18.3 1.0 0.0053 17.2 1.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding GDP_Man_Dehyd PF16363.5 ORX74773.1 - 0.0072 15.8 0.3 0.015 14.7 0.3 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ORX74773.1 - 0.012 15.5 0.4 0.019 14.9 0.4 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ORX74773.1 - 0.019 14.1 0.1 0.028 13.6 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ORX74773.1 - 0.035 13.1 0.3 0.055 12.5 0.3 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family CobU PF02283.16 ORX74773.1 - 0.045 13.3 0.2 0.075 12.6 0.2 1.3 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Ferrochelatase PF00762.19 ORX74773.1 - 0.051 12.7 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Ferrochelatase ApbA PF02558.16 ORX74773.1 - 0.056 13.1 0.1 0.095 12.3 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF5352 PF17303.2 ORX74773.1 - 0.075 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5352) Prenyltransf PF01255.19 ORX74773.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase THUMP PF02926.17 ORX74773.1 - 0.19 11.8 1.1 0.48 10.5 1.1 1.7 1 1 0 1 1 1 0 THUMP domain DUF1688 PF07958.11 ORX74774.1 - 3.6e-145 483.9 0.0 4.1e-145 483.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TPR_12 PF13424.6 ORX74775.1 - 5.6e-05 23.4 0.3 0.0026 18.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX74775.1 - 8.3e-05 22.2 0.8 0.0052 16.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX74775.1 - 0.00014 21.7 3.8 0.033 14.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX74775.1 - 0.0083 16.6 0.6 3.3 8.3 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX74775.1 - 0.022 14.9 1.0 0.21 11.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX74775.1 - 0.14 13.0 2.3 1.2 10.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX74775.1 - 0.15 12.7 1.1 4.5 8.0 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_4 PF12799.7 ORX74776.1 - 3.7 8.1 0.0 3.7 8.1 0.0 3.3 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) LSM PF01423.22 ORX74777.1 - 1.4e-19 69.5 0.1 1.7e-19 69.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hexokinase_2 PF03727.16 ORX74779.1 - 5.8e-52 176.5 0.1 8.6e-52 176.0 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX74779.1 - 5.2e-29 101.6 0.1 9.3e-29 100.7 0.1 1.3 1 0 0 1 1 1 1 Hexokinase ROK PF00480.20 ORX74779.1 - 0.08 12.4 0.4 0.18 11.2 0.4 1.6 1 0 0 1 1 1 0 ROK family Abhydrolase_6 PF12697.7 ORX74780.1 - 5.8e-12 46.7 1.9 8.9e-12 46.1 1.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX74780.1 - 0.00064 19.1 0.2 0.0031 16.8 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74780.1 - 0.0014 18.3 0.1 0.0017 18.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3591 PF12157.8 ORX74781.1 - 4.5e-172 572.7 0.0 5.5e-172 572.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 ORX74781.1 - 4.1e-06 26.5 1.9 9.9e-06 25.3 1.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ORX74781.1 - 0.09 12.9 1.3 0.17 12.0 1.3 1.4 1 0 0 1 1 1 0 Zinc knuckle CytochromB561_N PF09786.9 ORX74781.1 - 0.18 10.8 0.1 0.42 9.6 0.0 1.6 2 0 0 2 2 2 0 Cytochrome B561, N terminal Pkinase PF00069.25 ORX74782.1 - 2.3e-09 37.0 0.0 3e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 ORX74782.1 - 3.2e-06 26.9 0.0 4.4e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ORX74782.1 - 5.2e-05 22.7 0.1 8.5e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX74782.1 - 0.00021 21.3 0.4 0.00041 20.4 0.4 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ORX74782.1 - 0.0017 17.7 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX74782.1 - 0.0081 15.0 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase EcKinase PF02958.20 ORX74782.1 - 0.052 12.9 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase DUF4135 PF13575.6 ORX74782.1 - 0.13 11.6 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Sad1_UNC PF07738.13 ORX74783.1 - 6.7e-31 107.0 0.1 3.1e-30 104.9 0.0 2.0 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal FliJ PF02050.16 ORX74783.1 - 0.75 10.0 9.0 1.9 8.7 9.0 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein APH PF01636.23 ORX74784.1 - 1.1e-12 48.4 0.0 1.9e-12 47.6 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX74784.1 - 2.5e-05 23.8 0.0 6.2e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ORX74784.1 - 0.017 14.7 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 ORX74784.1 - 0.038 13.2 0.0 1.4 8.0 0.0 2.5 3 0 0 3 3 3 0 Fructosamine kinase EIIA-man PF03610.16 ORX74784.1 - 0.052 13.8 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 PTS system fructose IIA component PH PF00169.29 ORX74785.1 - 7.9e-15 55.3 0.1 1.2e-14 54.7 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ORX74785.1 - 0.004 17.6 0.8 0.019 15.4 0.6 2.0 1 1 1 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ORX74785.1 - 0.01 16.2 0.3 0.043 14.2 0.3 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain PH_12 PF16457.5 ORX74785.1 - 0.016 15.8 0.8 0.17 12.4 0.8 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain COG2 PF06148.11 ORX74785.1 - 0.11 12.6 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 PH_5 PF15405.6 ORX74785.1 - 0.15 12.1 0.1 0.36 10.9 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Fucosidase_C PF16757.5 ORX74786.1 - 0.023 15.2 0.0 0.062 13.9 0.0 1.7 1 0 0 1 1 1 0 Alpha-L-fucosidase C-terminal domain DUF1794 PF08768.11 ORX74786.1 - 0.05 13.6 0.4 0.087 12.8 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1794) TFIIA PF03153.13 ORX74786.1 - 3.3 7.6 20.5 0.19 11.7 15.6 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit TBCC PF07986.12 ORX74790.1 - 2e-28 98.5 0.0 3.4e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 ORX74790.1 - 8.9e-05 22.9 1.3 8.9e-05 22.9 1.3 2.1 2 1 0 2 2 2 1 Tubulin-specific chaperone C N-terminal domain FCH PF00611.23 ORX74791.1 - 1.6e-13 50.8 0.0 4.3e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.27 ORX74791.1 - 6.2e-12 45.6 0.0 4e-11 43.0 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.21 ORX74791.1 - 1e-06 28.7 0.0 2.1e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Acetyltransf_11 PF13720.6 ORX74791.1 - 0.015 15.8 0.2 0.87 10.1 0.0 3.6 3 1 1 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 IGR PF09597.10 ORX74792.1 - 3.5e-22 78.3 0.6 4.7e-22 77.8 0.6 1.2 1 0 0 1 1 1 1 IGR protein motif SRP19 PF01922.17 ORX74793.1 - 7.2e-30 103.8 0.0 1.2e-29 103.0 0.0 1.4 1 0 0 1 1 1 1 SRP19 protein Drf_GBD PF06371.13 ORX74794.1 - 9.6e-13 48.1 1.2 4.1e-12 46.0 1.2 2.0 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX74794.1 - 3.7e-06 26.7 0.0 7.8e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Diaphanous FH3 Domain NUDIX PF00293.28 ORX74795.1 - 2.1e-06 27.8 0.0 5.7e-06 26.4 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain FAR1 PF03101.15 ORX74796.1 - 2.4e-13 50.6 0.8 1e-12 48.6 0.8 2.0 1 1 0 1 1 1 1 FAR1 DNA-binding domain DUF5531 PF17671.1 ORX74797.1 - 0.045 13.6 0.4 0.094 12.6 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5531) NIF PF03031.18 ORX74798.1 - 1.5e-26 93.1 0.0 1.5e-25 89.8 0.0 2.3 3 0 0 3 3 3 1 NLI interacting factor-like phosphatase Biotin_lipoyl_2 PF13533.6 ORX74798.1 - 0.00013 21.7 0.0 0.0019 18.0 0.0 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 ORX74798.1 - 0.00065 20.4 0.0 0.008 16.9 0.0 2.4 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl PF00364.22 ORX74798.1 - 0.0064 16.3 0.0 0.28 11.0 0.0 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme HlyD_D23 PF16576.5 ORX74798.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Abhydrolase_6 PF12697.7 ORX74800.1 - 5.3e-13 50.1 0.0 8.5e-13 49.4 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX74800.1 - 3.7e-05 23.1 0.0 0.00011 21.6 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX74800.1 - 0.0079 15.9 0.0 0.021 14.5 0.0 1.8 2 1 1 3 3 3 1 alpha/beta hydrolase fold zf-His_Me_endon PF05551.11 ORX74801.1 - 0.00019 21.6 0.9 0.00019 21.6 0.9 2.0 2 1 0 2 2 2 1 Zinc-binding loop region of homing endonuclease HNH_3 PF13392.6 ORX74801.1 - 0.012 15.4 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 HNH endonuclease Aldedh PF00171.22 ORX74802.1 - 1.7e-75 254.3 0.0 2.3e-75 253.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Med31 PF05669.12 ORX74803.1 - 1.4e-36 124.3 7.7 1.8e-36 124.0 7.7 1.1 1 0 0 1 1 1 1 SOH1 AA_kinase PF00696.28 ORX74804.1 - 5e-39 134.3 0.3 1.1e-38 133.2 0.1 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 ORX74804.1 - 4.5e-15 55.1 1.5 2.4e-07 30.4 0.1 3.0 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 ORX74804.1 - 4.7e-12 45.5 3.3 1.1e-07 31.5 0.4 2.5 2 0 0 2 2 2 2 ACT domain FAD-oxidase_C PF02913.19 ORX74805.1 - 4.5e-36 124.8 0.1 6.2e-36 124.3 0.1 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX74805.1 - 8.7e-36 122.7 1.5 1.3e-35 122.1 1.5 1.3 1 0 0 1 1 1 1 FAD binding domain Lact-deh-memb PF09330.11 ORX74805.1 - 0.0088 15.4 0.1 0.018 14.4 0.1 1.5 1 1 0 1 1 1 1 D-lactate dehydrogenase, membrane binding Pex16 PF08610.10 ORX74806.1 - 8.5e-51 173.0 2.2 1.9e-50 171.9 2.2 1.5 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) BPL_LplA_LipB PF03099.19 ORX74807.1 - 3.3e-06 27.0 0.0 5.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family P34-Arc PF04045.14 ORX74808.1 - 5.2e-98 327.6 0.5 6.8e-98 327.2 0.5 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Homeobox_KN PF05920.11 ORX74809.1 - 2.3e-06 27.4 1.2 5.7e-06 26.1 1.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX74809.1 - 0.0054 16.6 1.1 0.014 15.3 1.1 1.7 1 0 0 1 1 1 1 Homeodomain Nab2p_Zf1 PF18260.1 ORX74810.1 - 0.78 9.7 6.6 1.1 9.2 0.0 2.8 3 0 0 3 3 3 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 DUF4588 PF15251.6 ORX74812.1 - 0.00058 19.7 1.2 0.0013 18.6 0.2 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4588) CENP-X PF09415.10 ORX74813.1 - 6.4e-17 61.6 0.4 2.4e-16 59.8 0.0 2.0 2 0 0 2 2 2 1 CENP-S associating Centromere protein X BLOC1_2 PF10046.9 ORX74813.1 - 4.6e-10 39.7 3.5 6.9e-09 35.9 1.9 2.3 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TerB_N PF13208.6 ORX74813.1 - 0.022 14.5 0.3 0.033 13.9 0.3 1.4 1 0 0 1 1 1 0 TerB N-terminal domain Biopterin_H PF00351.21 ORX74813.1 - 0.03 13.4 0.1 0.037 13.1 0.1 1.1 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase Sec3_C_2 PF15278.6 ORX74813.1 - 0.074 13.4 0.2 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Sec3 exocyst complex subunit MoaC PF01967.21 ORX74814.1 - 2.9e-17 63.0 0.2 3.8e-17 62.6 0.2 1.1 1 0 0 1 1 1 1 MoaC family NfeD PF01957.18 ORX74814.1 - 0.043 14.2 0.1 0.061 13.7 0.1 1.3 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding U79_P34 PF03064.16 ORX74814.1 - 0.15 11.4 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pkinase PF00069.25 ORX74815.1 - 4.2e-42 144.3 1.6 1.1e-19 70.8 0.0 3.4 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74815.1 - 6.2e-14 51.9 2.7 1.2e-08 34.6 0.0 3.5 3 1 1 4 4 4 3 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX74815.1 - 0.00024 20.1 0.1 0.00038 19.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX74815.1 - 0.0013 18.2 0.1 0.0029 17.0 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX74815.1 - 0.0018 18.3 0.3 0.0033 17.4 0.3 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX74815.1 - 0.02 14.2 0.0 0.07 12.4 0.0 1.8 1 1 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 ORX74815.1 - 0.036 13.1 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.11 ORX74815.1 - 0.068 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 ORX74815.1 - 0.083 11.7 0.1 0.14 10.9 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_C PF00433.24 ORX74815.1 - 2.4 8.9 5.1 0.76 10.5 1.1 2.3 2 0 0 2 2 2 0 Protein kinase C terminal domain DUF3754 PF12576.8 ORX74816.1 - 0.082 12.9 3.4 1.1 9.2 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3754) RrnaAD PF00398.20 ORX74817.1 - 5.5e-24 84.7 0.0 2e-20 73.0 0.0 2.1 2 0 0 2 2 2 2 Ribosomal RNA adenine dimethylase Med4 PF10018.9 ORX74818.1 - 4.6e-11 42.8 1.6 8.1e-11 42.0 1.6 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 TPR_8 PF13181.6 ORX74819.1 - 3e-06 27.0 0.1 6 7.3 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX74819.1 - 1.2e-05 25.0 9.6 0.0096 16.0 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX74819.1 - 2.7e-05 23.8 0.3 0.008 16.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX74819.1 - 0.018 15.0 3.3 0.8 9.9 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX74819.1 - 0.019 15.7 0.4 0.019 15.7 0.4 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat Coatomer_E PF04733.14 ORX74819.1 - 0.048 13.1 0.1 0.11 11.9 0.1 1.6 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_12 PF13424.6 ORX74819.1 - 0.073 13.4 11.9 10 6.5 0.0 5.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX74819.1 - 0.089 13.5 6.8 20 6.1 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX74819.1 - 0.11 12.9 4.3 12 6.5 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX74819.1 - 0.2 12.2 17.7 0.08 13.5 0.5 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 ORX74820.1 - 2.1e-37 129.1 0.0 2.7e-37 128.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II ABC_transp_aux PF09822.9 ORX74820.1 - 0.11 12.0 0.0 0.55 9.6 0.0 1.9 2 0 0 2 2 2 0 ABC-type uncharacterized transport system BCNT PF07572.12 ORX74821.1 - 9.1e-17 60.9 2.1 1.5e-16 60.2 2.1 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development EF-hand_5 PF13202.6 ORX74821.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF2894 PF11445.8 ORX74821.1 - 0.13 12.8 5.3 0.17 12.3 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Nro1 PF12753.7 ORX74822.1 - 1.4e-16 60.5 7.6 2.8e-13 49.6 0.2 2.4 1 1 0 2 2 2 2 Nuclear pore complex subunit Nro1 TPR_16 PF13432.6 ORX74822.1 - 0.0046 17.6 12.1 0.066 13.9 0.3 4.7 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX74822.1 - 0.057 13.5 7.2 28 5.1 0.1 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX74822.1 - 0.17 12.4 0.3 0.17 12.4 0.3 4.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX74822.1 - 0.19 12.7 16.7 0.32 11.9 0.7 5.3 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX74822.1 - 0.82 10.4 6.1 1.7 9.4 0.4 4.3 4 2 0 4 4 4 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 ORX74822.1 - 2.9 8.0 9.9 4.9 7.3 0.5 4.2 5 0 0 5 5 5 0 Exonuclease VII small subunit TPR_2 PF07719.17 ORX74822.1 - 6.4 7.1 11.7 22 5.5 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 ORX74823.1 - 0.0025 18.6 0.0 1.2 10.1 0.0 3.2 4 0 0 4 4 4 1 WD domain, G-beta repeat Lactonase PF10282.9 ORX74823.1 - 0.0028 17.0 0.0 0.0038 16.5 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 ORX74823.1 - 0.0042 17.3 0.0 1.4 9.3 0.0 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3108 PF11306.8 ORX74824.1 - 0.05 13.6 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) Methyltransf_11 PF08241.12 ORX74824.1 - 0.068 13.8 0.0 0.18 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ORX74824.1 - 0.096 12.5 0.0 0.31 10.9 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 ORX74825.1 - 1.1e-55 188.8 0.0 1.6e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74825.1 - 3e-25 89.0 0.0 4.3e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX74825.1 - 3e-06 26.8 0.0 6.7e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX74825.1 - 0.0045 16.9 0.6 0.055 13.4 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX74825.1 - 0.11 11.8 0.1 0.21 10.9 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX74825.1 - 0.15 11.6 0.6 0.51 9.9 0.6 1.8 1 1 0 1 1 1 0 RIO1 family ProRS-C_1 PF09180.11 ORX74826.1 - 1.1e-25 89.7 0.2 2e-25 88.8 0.2 1.5 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 ORX74826.1 - 2.8e-19 69.8 0.0 4.9e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX74826.1 - 6e-19 68.0 0.0 1.6e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.15 ORX74826.1 - 2.3e-16 60.0 1.0 3e-16 59.6 0.2 1.6 2 0 0 2 2 2 1 Aminoacyl-tRNA editing domain Mob_synth_C PF06463.13 ORX74827.1 - 1.4e-36 125.3 0.0 1.9e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 ORX74827.1 - 1.2e-16 61.6 0.3 3e-16 60.3 0.1 1.7 2 1 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 ORX74827.1 - 0.034 14.4 0.0 0.063 13.6 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain DUF3459 PF11941.8 ORX74827.1 - 0.08 13.3 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) DUF2505 PF10698.9 ORX74827.1 - 0.19 11.8 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) Pyr_redox_2 PF07992.14 ORX74828.1 - 3.5e-21 75.7 0.0 9.8e-21 74.2 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX74828.1 - 5.7e-05 23.6 1.9 0.081 13.5 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX74828.1 - 0.00049 20.1 0.4 3.7 7.5 0.1 3.5 3 0 0 3 3 3 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ORX74828.1 - 0.029 13.2 0.5 0.12 11.2 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.6 ORX74828.1 - 0.036 14.3 0.0 3.9 7.8 0.0 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX74828.1 - 0.037 13.3 0.1 1 8.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX74828.1 - 0.037 13.3 1.8 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Eno-Rase_NADH_b PF12242.8 ORX74828.1 - 0.078 12.8 0.4 0.35 10.7 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DAO PF01266.24 ORX74828.1 - 0.12 11.9 3.0 2.7 7.5 0.0 2.8 2 1 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ORX74828.1 - 0.13 11.2 0.3 11 5.0 0.2 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein GIDA PF01134.22 ORX74828.1 - 0.79 8.7 1.7 21 4.1 0.0 2.9 4 0 0 4 4 4 0 Glucose inhibited division protein A PRP3 PF08572.10 ORX74830.1 - 4e-49 167.3 3.4 8.3e-25 87.8 2.8 2.4 2 0 0 2 2 2 2 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 ORX74830.1 - 1.6e-41 141.9 1.6 2.6e-41 141.1 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) EccE PF11203.8 ORX74830.1 - 1.3 9.4 4.7 0.49 10.7 0.4 2.5 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE WD40 PF00400.32 ORX74831.1 - 6.1e-15 55.4 0.8 1.9e-05 25.3 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74831.1 - 8.2e-08 32.4 0.0 0.042 14.1 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 ORX74831.1 - 0.0001 21.8 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 ORX74831.1 - 0.02 13.9 0.1 0.97 8.3 0.1 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FXMRP1_C_core PF12235.8 ORX74831.1 - 0.73 10.5 9.3 1.5 9.4 9.3 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal EAF PF09816.9 ORX74832.1 - 2.9e-06 27.6 0.0 8.6e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Rad51 PF08423.11 ORX74833.1 - 2.7e-12 46.5 0.0 4.1e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 ORX74833.1 - 5.8e-07 29.1 0.1 6.4e-06 25.7 0.0 2.2 2 1 0 2 2 2 1 KaiC AAA_25 PF13481.6 ORX74833.1 - 6e-07 29.2 0.5 7.3e-06 25.7 0.1 2.2 1 1 1 2 2 2 1 AAA domain RecA PF00154.21 ORX74833.1 - 0.00012 21.7 0.3 0.0025 17.3 0.0 2.2 2 0 0 2 2 2 1 recA bacterial DNA recombination protein PAXNEB PF05625.11 ORX74833.1 - 0.0013 18.0 0.1 0.0021 17.3 0.1 1.2 1 0 0 1 1 1 1 PAXNEB protein DnaB_C PF03796.15 ORX74833.1 - 0.0033 16.8 0.0 0.0077 15.6 0.0 1.6 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 ORX74833.1 - 0.02 14.7 0.2 0.062 13.0 0.1 1.8 1 1 1 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 ORX74833.1 - 0.03 14.6 0.0 0.083 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX74833.1 - 0.068 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 ORX74833.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase TniB PF05621.11 ORX74833.1 - 0.11 11.8 0.0 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 ORX74833.1 - 0.19 12.3 0.7 0.79 10.3 0.7 2.2 1 1 0 1 1 1 0 AAA domain SH3_9 PF14604.6 ORX74834.1 - 4.3e-05 23.3 0.0 4.9e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX74834.1 - 0.0002 20.9 0.0 0.00024 20.6 0.0 1.1 1 0 0 1 1 1 1 SH3 domain HCNGP PF07818.13 ORX74835.1 - 3.5e-21 75.6 0.3 2e-20 73.2 0.0 2.2 1 1 2 3 3 3 1 HCNGP-like protein Mucin PF01456.17 ORX74836.1 - 1.4 8.9 17.8 9.8 6.2 12.7 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1917 PF08939.10 ORX74837.1 - 0.0068 16.3 7.5 23 4.8 0.1 4.8 4 1 1 5 5 5 4 Domain of unknown function (DUF1917) FMN_red PF03358.15 ORX74839.1 - 4e-13 49.4 0.0 5.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX74839.1 - 1.4e-06 28.2 0.0 1.9e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX74839.1 - 0.039 14.2 0.1 0.088 13.0 0.0 1.7 2 1 0 2 2 2 0 Flavodoxin CHAP PF05257.16 ORX74840.1 - 1.3e-10 41.7 4.1 2.8e-10 40.6 4.1 1.6 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX74840.1 - 1.6e-05 25.1 0.1 3.8e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Pcc1 PF09341.10 ORX74841.1 - 5.5e-21 74.5 0.3 6e-21 74.4 0.3 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 GLTP PF08718.11 ORX74842.1 - 1.1e-43 149.1 0.0 1.3e-43 148.8 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) NDC10_II PF16787.5 ORX74844.1 - 5.6e-11 42.1 0.0 5.8e-05 22.3 0.0 2.5 2 1 0 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 F-box-like PF12937.7 ORX74846.1 - 0.00011 22.0 0.2 0.00041 20.2 0.0 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX74846.1 - 0.00066 19.5 0.0 0.0021 17.9 0.0 1.9 1 0 0 1 1 1 1 F-box domain RseA_C PF03873.13 ORX74846.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain PAP_central PF04928.17 ORX74847.1 - 2.2e-83 279.1 0.0 3.3e-83 278.5 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ORX74847.1 - 3.5e-26 91.9 0.6 8.3e-26 90.6 0.1 1.9 1 1 1 2 2 2 1 Poly(A) polymerase predicted RNA binding domain Nrap_D2 PF17403.2 ORX74847.1 - 0.068 12.9 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Ammonium_transp PF00909.21 ORX74851.1 - 1.4e-119 399.4 26.6 1.6e-119 399.2 26.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF4079 PF13301.6 ORX74851.1 - 1.9 8.6 9.1 1 9.5 1.4 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF4079) Pyr_redox_2 PF07992.14 ORX74853.1 - 3.1e-23 82.5 0.1 1.3e-22 80.4 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX74853.1 - 8.9e-07 28.3 0.0 1.4e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 ORX74853.1 - 3.1e-06 27.7 0.2 1.9e-05 25.1 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX74853.1 - 0.0011 18.6 0.0 0.34 10.4 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ORX74853.1 - 0.016 14.1 0.0 0.068 12.0 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 ORX74853.1 - 0.062 12.3 0.0 0.55 9.2 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein CHAP PF05257.16 ORX74855.1 - 2.3e-13 50.5 4.1 4.7e-13 49.5 4.1 1.5 1 0 0 1 1 1 1 CHAP domain SH3_3 PF08239.11 ORX74855.1 - 2.9e-05 24.3 0.1 6.8e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain FMN_red PF03358.15 ORX74856.1 - 3.1e-13 49.7 0.0 4.5e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX74856.1 - 8.4e-07 28.9 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX74856.1 - 0.049 13.8 0.2 0.094 12.9 0.0 1.6 2 1 0 2 2 2 0 Flavodoxin Sugar_tr PF00083.24 ORX74857.1 - 6.1e-97 325.3 23.1 7.6e-97 325.0 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX74857.1 - 6.6e-31 107.5 65.7 3.6e-28 98.5 31.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX74857.1 - 0.00029 19.4 2.9 0.00029 19.4 2.9 2.4 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF4006 PF13179.6 ORX74857.1 - 0.29 11.1 2.5 18 5.3 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF4006) DUF4231 PF14015.6 ORX74857.1 - 5.6 7.5 7.3 0.89 10.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) F-box-like PF12937.7 ORX74858.1 - 0.004 17.0 0.1 0.025 14.5 0.1 2.4 2 0 0 2 2 2 1 F-box-like USP7_ICP0_bdg PF12436.8 ORX74859.1 - 3.1e-33 115.1 0.0 4.2e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 ORX74859.1 - 5.2e-27 95.0 0.0 8.9e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX74859.1 - 1.2e-07 31.7 0.0 2.7e-06 27.2 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX74859.1 - 2.8e-06 27.4 0.0 6.8e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 MATH domain WD40 PF00400.32 ORX74860.1 - 4.6e-24 84.2 13.9 9.7e-08 32.6 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX74860.1 - 9.2e-10 38.7 0.1 0.001 19.3 0.0 5.2 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX74860.1 - 2.2e-07 31.0 0.0 0.018 15.0 0.0 3.7 4 0 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.10 ORX74860.1 - 0.0018 18.0 0.4 0.0038 17.0 0.4 1.6 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 ORX74860.1 - 0.015 15.2 0.5 2.4 8.2 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat GATA PF00320.27 ORX74861.1 - 2.4e-12 46.2 3.0 4.4e-12 45.4 3.0 1.5 1 0 0 1 1 1 1 GATA zinc finger VCX_VCY PF15231.6 ORX74861.1 - 0.079 13.6 1.0 0.15 12.8 1.0 1.4 1 0 0 1 1 1 0 Variable charge X/Y family AAA_16 PF13191.6 ORX74862.1 - 4.1e-05 24.0 0.1 8.5e-05 23.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 ORX74862.1 - 0.00014 21.8 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 ORX74862.1 - 0.00042 20.2 0.2 0.015 15.2 0.1 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 ORX74862.1 - 0.0012 19.4 0.0 0.0064 17.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain PRK PF00485.18 ORX74862.1 - 0.0012 18.6 0.0 0.0051 16.6 0.0 2.1 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 ORX74862.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 ORX74862.1 - 0.0023 17.7 0.0 0.0072 16.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX74862.1 - 0.0037 17.4 0.1 0.0093 16.1 0.0 2.0 2 1 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 ORX74862.1 - 0.0039 17.1 0.1 0.0064 16.4 0.1 1.3 1 0 0 1 1 1 1 NTPase Zeta_toxin PF06414.12 ORX74862.1 - 0.004 16.4 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 ORX74862.1 - 0.0041 17.1 0.0 0.0083 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 ORX74862.1 - 0.0091 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein KAP_NTPase PF07693.14 ORX74862.1 - 0.017 14.3 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain cobW PF02492.19 ORX74862.1 - 0.023 14.3 0.1 0.037 13.6 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 ORX74862.1 - 0.041 13.1 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 ORX74862.1 - 0.041 13.6 0.6 0.15 11.8 0.0 2.2 3 0 0 3 3 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ORX74862.1 - 0.042 14.4 0.0 0.08 13.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA PF00004.29 ORX74862.1 - 0.043 14.2 0.0 0.081 13.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ORX74862.1 - 0.044 14.3 0.0 0.21 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ORX74862.1 - 0.045 13.4 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ORX74862.1 - 0.05 13.8 0.0 0.4 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ORX74862.1 - 0.056 13.3 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 ORX74862.1 - 0.059 12.4 0.0 0.092 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Adeno_IVa2 PF02456.15 ORX74862.1 - 0.062 12.1 0.1 0.094 11.5 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_11 PF13086.6 ORX74862.1 - 0.071 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 ORX74862.1 - 0.08 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase AAA_19 PF13245.6 ORX74862.1 - 0.08 13.3 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 ORX74862.1 - 0.16 12.0 0.1 0.32 11.0 0.2 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_7 PF12775.7 ORX74862.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF382 PF04037.13 ORX74864.1 - 4.7e-54 181.9 0.4 4.7e-54 181.9 0.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 ORX74864.1 - 7e-20 70.6 3.4 1.8e-19 69.3 3.4 1.8 1 0 0 1 1 1 1 PSP SnAC PF14619.6 ORX74864.1 - 0.26 11.9 6.2 0.56 10.8 0.2 2.3 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex WD40 PF00400.32 ORX74865.1 - 4.6e-20 71.6 8.0 0.00012 22.8 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ORX74865.1 - 0.043 12.6 0.2 4.2 6.0 0.1 2.7 1 1 0 2 2 2 0 Nup133 N terminal like PQQ_3 PF13570.6 ORX74865.1 - 0.82 10.2 4.1 26 5.5 0.2 5.0 5 2 1 6 6 6 0 PQQ-like domain Peptidase_S8 PF00082.22 ORX74868.1 - 1.7e-53 181.8 6.2 3e-53 181.0 6.2 1.4 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX74868.1 - 5.6e-18 64.8 0.7 1.8e-17 63.1 0.7 1.8 1 0 0 1 1 1 1 PA domain fn3_5 PF06280.12 ORX74868.1 - 2.6e-05 24.9 0.0 0.0013 19.4 0.0 3.3 3 0 0 3 3 3 1 Fn3-like domain Inhibitor_I9 PF05922.16 ORX74868.1 - 0.0014 19.2 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 ORX74869.1 - 1.7e-48 165.4 0.0 3.5e-48 164.4 0.0 1.4 1 1 0 1 1 1 1 Subtilase family PA PF02225.22 ORX74869.1 - 4.2e-16 58.7 1.5 8.5e-16 57.8 0.4 2.1 1 1 1 2 2 2 1 PA domain fn3_5 PF06280.12 ORX74869.1 - 0.0059 17.3 0.1 0.052 14.2 0.0 2.6 3 0 0 3 3 3 1 Fn3-like domain Peptidase_S8 PF00082.22 ORX74870.1 - 8.2e-51 173.0 6.5 1.4e-50 172.2 6.5 1.3 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX74870.1 - 1.3e-15 57.2 0.9 3.5e-15 55.8 0.2 2.1 1 1 1 2 2 2 1 PA domain fn3_5 PF06280.12 ORX74870.1 - 0.00089 19.9 0.0 0.013 16.1 0.0 2.6 2 0 0 2 2 2 1 Fn3-like domain Inhibitor_I9 PF05922.16 ORX74870.1 - 0.0022 18.6 0.0 0.0059 17.3 0.0 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF2561 PF10812.8 ORX74871.1 - 0.0099 15.9 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) NAR2 PF16974.5 ORX74871.1 - 0.16 11.3 0.5 0.32 10.4 0.5 1.4 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Cyclin_N PF00134.23 ORX74873.1 - 1.3e-08 34.7 0.0 2.4e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain MeMO_Hyd_G PF02964.16 ORX74873.1 - 0.0056 16.7 0.0 0.0085 16.1 0.0 1.2 1 0 0 1 1 1 1 Methane monooxygenase, hydrolase gamma chain TFIIB PF00382.19 ORX74873.1 - 0.06 13.4 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Cyclin_C PF02984.19 ORX74873.1 - 0.14 12.2 0.5 5 7.2 0.1 3.0 2 1 0 2 2 2 0 Cyclin, C-terminal domain Acetyltransf_1 PF00583.25 ORX74874.1 - 1.1e-10 41.7 0.0 1.6e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX74874.1 - 5.2e-07 29.7 0.0 6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX74874.1 - 5.5e-06 26.7 0.0 9.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ORX74874.1 - 3.6e-05 23.5 0.0 6.6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX74874.1 - 0.00057 20.0 0.0 0.00079 19.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX74874.1 - 0.025 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_15 PF17013.5 ORX74874.1 - 0.15 11.5 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase AhpC-TSA PF00578.21 ORX74875.1 - 1e-27 96.5 0.0 1.5e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 ORX74875.1 - 8e-11 41.6 0.0 1.8e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 ORX74875.1 - 1.2e-08 34.7 0.0 1.6e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin Dcc1 PF09724.9 ORX74876.1 - 1.8e-08 34.1 0.0 1e-07 31.6 0.0 1.9 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 PGP_phosphatase PF09419.10 ORX74877.1 - 4.1e-31 107.8 0.0 6.7e-18 64.9 0.0 2.0 1 1 1 2 2 2 2 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 ORX74877.1 - 2.4e-05 24.3 0.1 3.1e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 HAD-hyrolase-like RRM_1 PF00076.22 ORX74878.1 - 1.2e-32 111.6 1.9 3.4e-15 55.6 0.3 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX74878.1 - 2.3e-05 24.4 0.2 0.11 12.6 0.0 3.2 2 2 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 ORX74878.1 - 0.058 13.2 0.0 0.65 9.8 0.0 2.5 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain SRP-alpha_N PF04086.13 ORX74878.1 - 0.23 11.4 9.5 0.31 10.9 9.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 ORX74878.1 - 4.2 6.0 4.3 5.4 5.7 4.3 1.1 1 0 0 1 1 1 0 Presenilin Wzy_C PF04932.15 ORX74879.1 - 0.012 15.2 0.2 1.2 8.7 0.1 2.5 2 0 0 2 2 2 0 O-Antigen ligase FA_desaturase PF00487.24 ORX74879.1 - 7.7 6.3 12.4 2.7 7.7 0.8 2.7 2 0 0 2 2 2 0 Fatty acid desaturase DUF998 PF06197.13 ORX74887.1 - 4.2e-05 23.2 11.6 4.2e-05 23.2 11.6 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF998) PalH PF08733.10 ORX74887.1 - 0.16 11.0 7.2 0.27 10.2 7.0 1.4 1 1 0 1 1 1 0 PalH/RIM21 SCAMP PF04144.13 ORX74887.1 - 4.2 7.6 14.2 3.8 7.8 4.1 2.8 1 1 0 2 2 2 0 SCAMP family E1-E2_ATPase PF00122.20 ORX74887.1 - 7.5 6.0 5.9 0.59 9.6 0.4 2.0 2 0 0 2 2 2 0 E1-E2 ATPase Ribosomal_S11 PF00411.19 ORX74888.1 - 1.5e-23 83.3 0.4 1.7e-23 83.1 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 SprB PF13573.6 ORX74888.1 - 0.12 12.2 0.7 0.18 11.6 0.7 1.3 1 0 0 1 1 1 0 SprB repeat adh_short PF00106.25 ORX74889.1 - 8.2e-08 31.9 2.9 1.6e-07 31.0 2.9 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX74889.1 - 2.3e-06 27.4 2.4 3.9e-06 26.6 2.4 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ORX74889.1 - 2.4e-06 27.2 0.4 2.3e-05 24.0 0.4 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family UCR_TM PF02921.14 ORX74889.1 - 0.75 10.3 3.7 0.32 11.5 0.5 2.0 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region EFP PF01132.20 ORX74890.1 - 3.5e-12 46.1 0.4 1.3e-11 44.4 0.5 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain Elong-fact-P_C PF09285.11 ORX74890.1 - 5.3e-12 45.3 0.7 5.7e-11 42.0 0.4 2.3 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.12 ORX74890.1 - 8.8e-09 35.3 1.0 1.6e-08 34.5 0.2 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain eIF-5a PF01287.20 ORX74890.1 - 0.017 15.2 1.1 0.068 13.3 0.4 2.2 2 0 0 2 2 2 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold C2 PF00168.30 ORX74891.1 - 2.8e-13 50.0 0.0 4.3e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 C2 domain vATP-synt_AC39 PF01992.16 ORX74892.1 - 1.2e-92 311.0 0.3 1.4e-92 310.8 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Herpes_UL6 PF01763.16 ORX74893.1 - 0.00066 18.3 0.5 0.004 15.7 0.1 1.9 2 0 0 2 2 2 1 Herpesvirus UL6 like ALIX_LYPXL_bnd PF13949.6 ORX74893.1 - 0.029 13.7 0.6 0.049 12.9 0.6 1.4 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV PSK_trans_fac PF07704.11 ORX74893.1 - 0.034 14.9 0.7 10 6.9 0.5 2.4 2 0 0 2 2 2 0 Rv0623-like transcription factor StbA PF06406.11 ORX74893.1 - 0.064 12.5 0.3 7.9 5.6 0.0 2.1 2 0 0 2 2 2 0 StbA protein Thiamine_BP PF01910.17 ORX74893.1 - 0.086 12.8 1.0 2.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Thiamine-binding protein DUF1664 PF07889.12 ORX74893.1 - 0.14 12.2 1.8 0.54 10.3 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LRR_8 PF13855.6 ORX74894.1 - 5 7.0 6.8 43 4.0 0.0 4.4 5 1 0 5 5 5 0 Leucine rich repeat Sugar_tr PF00083.24 ORX74895.1 - 1.6e-96 323.9 23.1 2e-96 323.6 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX74895.1 - 2.2e-31 109.1 64.3 1.2e-28 100.1 30.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX74895.1 - 3.2e-05 22.6 2.9 3.2e-05 22.6 2.9 2.4 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF4006 PF13179.6 ORX74895.1 - 0.29 11.1 2.5 18 5.3 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Trypsin PF00089.26 ORX74896.1 - 2.3e-25 89.7 0.6 2.8e-25 89.4 0.6 1.1 1 0 0 1 1 1 1 Trypsin Ssu72 PF04722.13 ORX74897.1 - 6.6e-81 270.5 0.0 7.3e-81 270.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Cyclin_N PF00134.23 ORX74898.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Cyclin, N-terminal domain Aminotran_5 PF00266.19 ORX74899.1 - 1.4e-90 304.0 0.0 1.6e-90 303.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ORX74899.1 - 6.3e-08 32.2 0.0 7.1e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ORX74899.1 - 4.3e-06 26.3 0.0 8.6e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ORX74899.1 - 1.7e-05 23.5 0.0 3.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 ORX74899.1 - 0.00063 18.6 0.0 0.001 17.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain RRM_1 PF00076.22 ORX74900.1 - 2.7e-22 78.4 0.0 1.3e-11 44.2 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 ORX74900.1 - 0.0026 17.8 1.8 0.0026 17.8 1.8 2.7 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 ORX74900.1 - 0.0055 15.7 5.5 0.52 9.2 4.7 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) Hydin_ADK PF17213.3 ORX74900.1 - 0.56 10.5 4.3 0.46 10.7 0.8 2.1 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Spt20 PF12090.8 ORX74900.1 - 0.6 9.7 14.9 0.17 11.4 4.1 2.2 2 0 0 2 2 2 0 Spt20 family E1-E2_ATPase PF00122.20 ORX74903.1 - 7.4e-31 107.1 0.0 4.3e-30 104.6 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX74903.1 - 6.1e-09 36.5 0.5 0.00079 19.8 0.5 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX74903.1 - 0.00035 20.2 1.4 0.0021 17.7 0.0 2.7 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX74903.1 - 0.0014 18.7 0.0 0.031 14.4 0.0 2.6 3 0 0 3 3 3 1 Cation transport ATPase (P-type) TBP PF00352.21 ORX74904.1 - 1.8e-55 184.8 0.8 4.7e-31 106.6 0.0 3.0 2 1 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 ORX74904.1 - 0.0057 16.7 0.0 2 8.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) MitMem_reg PF13012.6 ORX74905.1 - 6.8e-13 49.0 0.1 1.1e-12 48.4 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ORX74905.1 - 1.2e-12 47.8 0.0 2.2e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RRM_1 PF00076.22 ORX74906.1 - 2.5e-16 59.3 0.0 1.8e-10 40.5 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX74906.1 - 8.3e-10 38.3 0.0 0.0013 18.3 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOA36 PF06524.12 ORX74906.1 - 0.45 9.8 4.8 0.6 9.4 4.8 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ORX74906.1 - 4.6 5.2 7.5 5.4 5.0 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Palm_thioest PF02089.15 ORX74908.1 - 7.9e-79 264.9 0.0 8.9e-79 264.7 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 ORX74908.1 - 0.0053 16.3 0.0 0.0074 15.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 ORX74908.1 - 0.029 14.2 1.5 3 7.6 0.1 2.3 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase STAG PF08514.11 ORX74909.1 - 6.3e-21 74.4 1.7 6.3e-21 74.4 1.7 3.8 3 0 0 3 3 3 1 STAG domain HEAT PF02985.22 ORX74909.1 - 0.0012 18.9 0.9 1.6 9.2 0.0 4.4 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ORX74909.1 - 0.01 16.2 0.5 50 4.4 0.1 4.5 3 0 0 3 3 3 0 HEAT repeats BUD22 PF09073.10 ORX74909.1 - 8.7 5.6 38.4 0.42 9.9 6.2 2.7 2 0 0 2 2 2 0 BUD22 ALG11_N PF15924.5 ORX74910.1 - 2.4e-78 263.0 0.6 3.4e-78 262.5 0.6 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 ORX74910.1 - 4e-19 68.8 0.0 6.3e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX74910.1 - 2.4e-06 28.0 0.0 6.1e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX74910.1 - 1.7e-05 24.9 0.0 0.00016 21.7 0.0 2.4 3 0 0 3 3 3 1 Glycosyltransferase Family 4 PurL_C PF16904.5 ORX74910.1 - 0.082 13.2 0.0 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus RNase_PH PF01138.21 ORX74911.1 - 3.2e-20 73.0 0.0 5.1e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX74911.1 - 2.4e-14 53.1 0.0 4.4e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF3109 PF11307.8 ORX74911.1 - 0.18 11.6 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) DDE_Tnp_ISL3 PF01610.17 ORX74912.1 - 0.067 12.9 0.3 4.1 7.0 0.3 2.0 2 0 0 2 2 2 0 Transposase TMF_TATA_bd PF12325.8 ORX74913.1 - 0.0049 17.1 24.0 0.12 12.5 11.0 2.6 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding AAA_13 PF13166.6 ORX74913.1 - 0.009 14.7 14.8 0.014 14.1 14.8 1.2 1 0 0 1 1 1 1 AAA domain Filament PF00038.21 ORX74913.1 - 0.015 14.9 30.1 0.033 13.8 8.8 2.3 1 1 1 2 2 2 0 Intermediate filament protein Laminin_II PF06009.12 ORX74913.1 - 0.047 13.7 17.7 0.39 10.7 6.5 2.3 1 1 1 2 2 2 0 Laminin Domain II TMF_DNA_bd PF12329.8 ORX74913.1 - 0.12 12.4 20.3 0.28 11.2 6.6 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 ORX74913.1 - 0.17 10.7 28.9 0.1 11.5 1.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein FAM76 PF16046.5 ORX74913.1 - 0.19 11.1 18.4 0.79 9.0 0.4 2.1 1 1 1 2 2 2 0 FAM76 protein GrpE PF01025.19 ORX74913.1 - 0.19 11.4 24.1 0.033 13.8 3.1 3.1 1 1 2 3 3 3 0 GrpE ISG65-75 PF11727.8 ORX74913.1 - 0.23 10.7 21.5 0.54 9.4 7.7 2.4 1 1 1 2 2 2 0 Invariant surface glycoprotein FPP PF05911.11 ORX74913.1 - 0.28 9.3 19.8 3 5.9 18.8 1.9 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF3584 PF12128.8 ORX74913.1 - 0.29 8.6 29.3 0.39 8.2 29.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 ORX74913.1 - 0.52 10.8 29.1 3.3 8.3 29.0 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region BLOC1_2 PF10046.9 ORX74913.1 - 1.1 9.5 11.9 0.27 11.6 0.6 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 ORX74913.1 - 1.3 9.6 4.4 18 5.9 0.0 3.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF812 PF05667.11 ORX74913.1 - 2 7.2 25.2 9.1 5.0 23.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) PI3K_P85_iSH2 PF16454.5 ORX74913.1 - 2.2 7.9 21.0 6.2 6.4 1.3 2.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Golgin_A5 PF09787.9 ORX74913.1 - 2.7 7.4 29.3 2.1 7.8 12.9 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 ADIP PF11559.8 ORX74913.1 - 2.9 8.0 33.9 3.5 7.7 17.1 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 ORX74913.1 - 2.9 7.2 23.8 0.39 10.0 17.2 2.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF724 PF05266.14 ORX74913.1 - 3 7.6 22.5 1.8 8.4 9.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) YabA PF06156.13 ORX74913.1 - 3.7 8.2 15.0 0.41 11.3 2.5 2.8 1 1 0 2 2 2 0 Initiation control protein YabA ERM PF00769.19 ORX74913.1 - 5 6.9 32.2 6.8 6.4 32.2 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fib_alpha PF08702.10 ORX74913.1 - 5.1 7.3 16.5 0.54 10.4 1.6 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family EMP24_GP25L PF01105.24 ORX74913.1 - 5.3 6.9 15.5 3.8 7.4 4.0 2.6 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD SKA1 PF07160.12 ORX74913.1 - 7 6.4 17.7 6.4 6.6 7.3 2.5 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF4404 PF14357.6 ORX74913.1 - 8 7.2 16.8 1.3 9.8 2.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) FH2 PF02181.23 ORX74913.1 - 8.5 5.4 12.1 1 8.4 2.0 2.3 1 1 0 2 2 2 0 Formin Homology 2 Domain DUF948 PF06103.11 ORX74913.1 - 8.8 6.7 9.1 8.2 6.8 0.2 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) ZnuA PF01297.17 ORX74913.1 - 9.3 5.6 8.1 4.9 6.5 5.1 1.8 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic DUF1664 PF07889.12 ORX74913.1 - 9.3 6.3 14.2 3.3 7.7 2.6 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) MFS_1 PF07690.16 ORX74914.1 - 1.1e-12 47.5 33.4 1.6e-12 47.1 32.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ORX74914.1 - 7.1e-10 38.8 9.1 7.1e-10 38.8 9.1 2.4 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Myb_DNA-binding PF00249.31 ORX74915.1 - 1.2e-07 31.8 0.0 3.3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX74915.1 - 0.0051 17.0 0.0 0.0099 16.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Cwf_Cwc_15 PF04889.12 ORX74915.1 - 0.25 11.0 0.6 0.62 9.8 0.6 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Myb_DNA-binding PF00249.31 ORX74916.1 - 2.6e-05 24.3 0.0 3.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX74916.1 - 0.011 16.0 0.0 0.015 15.6 0.0 1.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain Sybindin PF04099.12 ORX74918.1 - 2.9e-29 101.8 0.0 3.8e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family zf-C2H2 PF00096.26 ORX74919.1 - 1.7e-07 31.3 13.6 0.00065 20.0 2.7 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX74919.1 - 7.4e-05 23.3 10.4 0.037 14.9 2.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX74919.1 - 0.00016 21.9 4.3 0.00016 21.9 4.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX74919.1 - 0.0011 18.9 7.8 0.0064 16.5 0.1 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 ORX74919.1 - 0.0067 16.8 1.7 0.17 12.3 0.3 2.5 2 1 0 2 2 2 1 Zinc-finger of C2H2 type HNH PF01844.23 ORX74919.1 - 0.017 15.2 2.1 0.083 13.1 2.1 2.0 1 1 0 1 1 1 0 HNH endonuclease zf-C2H2_8 PF15909.5 ORX74919.1 - 0.019 15.3 0.5 0.023 15.0 0.5 1.2 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX74919.1 - 0.044 13.5 2.3 0.044 13.5 2.3 1.7 2 0 0 2 2 2 0 zinc-finger C2H2-type E1-E2_ATPase PF00122.20 ORX74921.1 - 1.5e-24 86.6 0.6 6.2e-24 84.5 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX74921.1 - 1.8e-09 38.2 0.1 0.00014 22.2 0.0 2.7 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX74921.1 - 0.0026 17.8 0.0 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX74921.1 - 0.089 12.5 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus CTC1 PF15489.6 ORX74922.1 - 9.1e-09 33.4 12.3 0.00019 19.1 0.0 3.2 3 0 0 3 3 3 3 CST, telomere maintenance, complex subunit CTC1 zf-RanBP PF00641.18 ORX74923.1 - 9e-06 24.9 20.6 0.0065 15.8 4.3 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-C2H2 PF00096.26 ORX74924.1 - 1.7e-07 31.3 13.6 0.00065 20.0 2.7 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX74924.1 - 7.4e-05 23.3 10.4 0.037 14.9 2.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX74924.1 - 0.00016 21.9 4.3 0.00016 21.9 4.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX74924.1 - 0.0011 18.9 7.8 0.0064 16.5 0.1 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 ORX74924.1 - 0.0067 16.8 1.7 0.17 12.3 0.3 2.5 2 1 0 2 2 2 1 Zinc-finger of C2H2 type HNH PF01844.23 ORX74924.1 - 0.017 15.2 2.1 0.083 13.1 2.1 2.0 1 1 0 1 1 1 0 HNH endonuclease zf-C2H2_8 PF15909.5 ORX74924.1 - 0.019 15.3 0.5 0.023 15.0 0.5 1.2 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX74924.1 - 0.044 13.5 2.3 0.044 13.5 2.3 1.7 2 0 0 2 2 2 0 zinc-finger C2H2-type EamA PF00892.20 ORX74925.1 - 9.7e-22 77.6 23.2 3.2e-12 46.8 8.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family TENA_THI-4 PF03070.16 ORX74927.1 - 0.051 13.4 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 TENA/THI-4/PQQC family FAD_binding_1 PF00667.20 ORX74929.1 - 2e-45 155.1 0.0 3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX74929.1 - 4.9e-34 117.6 0.1 9.4e-34 116.7 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX74929.1 - 1.5e-15 57.7 0.0 4.7e-15 56.2 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain AAA PF00004.29 ORX74930.1 - 5.2e-39 133.7 0.0 9.2e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX74930.1 - 8.8e-12 44.6 0.1 1.8e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ORX74930.1 - 1.2e-05 25.6 0.1 0.0044 17.3 0.1 2.8 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 ORX74930.1 - 1.7e-05 24.2 0.1 6.1e-05 22.4 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 ORX74930.1 - 2.3e-05 24.2 0.0 0.00011 22.0 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX74930.1 - 6.3e-05 23.4 4.0 0.0051 17.2 0.1 3.3 2 2 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 ORX74930.1 - 7.8e-05 23.2 0.0 0.00023 21.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX74930.1 - 9.7e-05 21.8 0.5 0.0021 17.4 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ORX74930.1 - 0.00017 21.7 0.0 0.00038 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ORX74930.1 - 0.00019 21.4 0.5 0.002 18.1 0.5 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX74930.1 - 0.00045 20.4 0.0 0.0019 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ORX74930.1 - 0.0009 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 ORX74930.1 - 0.0054 16.5 0.0 0.0092 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX74930.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX74930.1 - 0.0061 16.1 0.1 0.035 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ORX74930.1 - 0.0081 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ORX74930.1 - 0.013 14.7 0.0 0.033 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Hydin_ADK PF17213.3 ORX74930.1 - 0.014 15.7 0.4 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RNA_helicase PF00910.22 ORX74930.1 - 0.018 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 ORX74930.1 - 0.02 14.3 0.0 1.4 8.2 0.0 2.5 1 1 1 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 ORX74930.1 - 0.022 14.3 0.1 0.061 12.8 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 ORX74930.1 - 0.047 13.0 0.1 1.2 8.4 0.1 2.3 1 1 1 2 2 2 0 KaiC IPT PF01745.16 ORX74930.1 - 0.062 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase Parvo_NS1 PF01057.17 ORX74930.1 - 0.067 12.3 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 ORX74930.1 - 0.075 12.9 0.2 0.28 11.1 0.1 2.0 3 0 0 3 3 3 0 NACHT domain PhoH PF02562.16 ORX74930.1 - 0.091 12.2 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein TsaE PF02367.17 ORX74930.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE bZIP_2 PF07716.15 ORX74931.1 - 8.7e-08 32.1 19.2 9.4e-08 32.0 15.3 2.5 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX74931.1 - 0.0017 18.4 14.9 0.66 10.1 11.3 2.3 2 0 0 2 2 2 2 bZIP transcription factor DUF1465 PF07323.12 ORX74931.1 - 0.055 13.3 11.4 0.066 13.0 10.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) FUSC PF04632.12 ORX74931.1 - 0.44 9.0 5.5 0.46 8.9 5.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pex26 PF07163.12 ORX74931.1 - 0.89 8.8 9.7 8.5 5.6 9.7 2.1 1 1 0 1 1 1 0 Pex26 protein Peptidase_S64 PF08192.11 ORX74931.1 - 0.9 7.9 5.1 1.2 7.5 5.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 FAM76 PF16046.5 ORX74931.1 - 1.7 7.9 6.8 2.1 7.6 6.8 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4578 PF15147.6 ORX74931.1 - 7.9 7.4 9.6 2 9.3 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4578) SNF5 PF04855.12 ORX74933.1 - 5.2e-34 118.1 2.4 4e-22 79.2 0.2 3.2 1 1 2 3 3 3 3 SNF5 / SMARCB1 / INI1 GATA PF00320.27 ORX74933.1 - 4.5e-09 35.8 5.3 1.3e-08 34.3 5.3 1.7 1 0 0 1 1 1 1 GATA zinc finger Antimicrobial17 PF08129.11 ORX74934.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta enterocin family HEAT PF02985.22 ORX74935.1 - 2.8e-31 104.9 31.0 0.0013 18.8 0.1 18.2 21 0 0 21 21 19 6 HEAT repeat HEAT_EZ PF13513.6 ORX74935.1 - 1.1e-24 86.5 49.5 0.012 16.1 0.1 16.5 15 2 2 17 17 15 6 HEAT-like repeat HEAT_2 PF13646.6 ORX74935.1 - 2.4e-18 66.3 40.9 0.00032 21.0 0.1 12.6 10 2 4 15 15 15 5 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX74935.1 - 2.5e-13 50.5 0.0 0.35 11.5 0.0 7.8 5 2 2 7 7 7 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX74935.1 - 3.3e-11 43.5 0.0 0.051 13.6 0.0 7.3 6 2 2 8 8 8 3 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 ORX74935.1 - 6.8e-10 38.8 5.1 3.7 7.5 0.1 9.7 8 2 3 11 11 11 1 UME (NUC010) domain CLASP_N PF12348.8 ORX74935.1 - 7.6e-08 32.2 0.0 0.011 15.3 0.0 4.8 4 1 0 4 4 4 2 CLASP N terminal Cohesin_HEAT PF12765.7 ORX74935.1 - 6.8e-05 23.1 7.3 0.18 12.2 0.1 5.6 5 0 0 5 5 5 1 HEAT repeat associated with sister chromatid cohesion Ecm29 PF13001.7 ORX74935.1 - 0.00013 20.8 0.0 7.2 5.2 0.2 4.7 4 1 1 5 5 5 2 Proteasome stabiliser RIX1 PF08167.12 ORX74935.1 - 0.012 15.4 0.1 13 5.4 0.0 4.5 4 0 0 4 4 4 0 rRNA processing/ribosome biogenesis MMS19_C PF12460.8 ORX74935.1 - 0.016 14.3 10.6 13 4.8 0.0 6.6 6 3 1 7 7 7 0 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 ORX74935.1 - 0.021 14.0 0.0 4.3 6.4 0.0 3.1 2 0 0 2 2 2 0 Dopey, N-terminal MMS19_N PF14500.6 ORX74935.1 - 1.4 8.5 5.3 43 3.6 0.0 4.8 6 1 0 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II Glyco_hydro_17 PF00332.18 ORX74936.1 - 3.9e-08 33.2 0.6 4.4e-07 29.8 0.2 2.1 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 Hamartin PF04388.12 ORX74936.1 - 3.7 6.1 4.2 4.6 5.8 4.2 1.1 1 0 0 1 1 1 0 Hamartin protein Inhibitor_I78 PF11720.8 ORX74938.1 - 0.053 13.6 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX74938.1 - 0.1 13.3 0.0 0.19 12.4 0.0 1.7 1 1 0 1 1 1 0 Potato inhibitor I family Pro_isomerase PF00160.21 ORX74939.1 - 4.9e-47 160.1 0.0 7.1e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ORX74939.1 - 7.2e-21 73.8 0.0 1.2e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX74939.1 - 0.0072 16.2 0.0 0.018 14.9 0.0 1.6 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 ORX74939.1 - 0.03 14.4 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ORX74939.1 - 0.033 14.2 0.0 0.074 13.1 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-ZPR1 PF03367.13 ORX74940.1 - 3.5e-110 364.9 0.5 2.2e-55 186.8 0.0 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain MEA1 PF06910.11 ORX74941.1 - 6.1e-10 39.8 1.2 6.1e-10 39.8 1.2 2.2 2 1 0 2 2 2 1 Male enhanced antigen 1 (MEA1) AF-4 PF05110.13 ORX74941.1 - 2.6 6.0 8.7 2.6 6.0 8.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pantoate_ligase PF02569.15 ORX74942.1 - 8.4e-97 323.5 0.0 9.5e-97 323.4 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ribosomal_L10 PF00466.20 ORX74947.1 - 3e-25 88.2 1.2 7e-25 87.1 0.2 2.0 2 1 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 ORX74947.1 - 2.5e-22 78.6 0.0 4.4e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 ORX74947.1 - 1.1e-20 74.0 13.1 1.1e-20 74.0 13.1 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein adh_short PF00106.25 ORX74948.1 - 1.3e-47 161.8 0.3 1.7e-47 161.5 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX74948.1 - 1.1e-34 120.1 0.1 1.4e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX74948.1 - 1.4e-05 25.0 0.1 2.2e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX74948.1 - 0.054 13.0 0.1 0.079 12.4 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family FapA PF03961.13 ORX74949.1 - 0.04 12.5 0.1 0.046 12.3 0.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Uricase PF01014.18 ORX74950.1 - 1e-56 190.8 0.1 2.7e-33 115.0 0.2 2.0 2 0 0 2 2 2 2 Uricase HK PF02110.15 ORX74951.1 - 1.6e-75 253.7 1.7 2.2e-75 253.2 1.7 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 ORX74951.1 - 1.1e-56 191.1 1.4 4.2e-56 189.2 0.7 2.1 2 0 0 2 2 2 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 ORX74952.1 - 5.3e-90 301.1 1.4 7.5e-90 300.6 1.4 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 ORX74952.1 - 1.4e-44 152.4 0.3 2.1e-44 151.8 0.3 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 ORX74952.1 - 1.1e-08 34.7 0.1 1.8e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 ORX74952.1 - 1.5e-05 24.5 0.5 3.8e-05 23.2 0.5 1.5 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family Reg_prop PF07494.11 ORX74953.1 - 0.048 13.9 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 Two component regulator propeller Rrp15p PF07890.12 ORX74954.1 - 5.7e-24 85.0 1.2 5.7e-24 85.0 1.2 2.1 1 1 1 2 2 2 1 Rrp15p RNA_pol_N PF01194.17 ORX74955.1 - 1.7e-33 114.7 0.7 1.9e-33 114.5 0.7 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 ORX74955.1 - 0.023 15.0 0.2 0.029 14.6 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Ion_trans PF00520.31 ORX74957.1 - 0.00017 20.9 12.5 0.00028 20.2 12.5 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ORX74957.1 - 0.0006 18.6 1.9 0.0006 18.6 1.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel MerR-DNA-bind PF09278.11 ORX74957.1 - 0.025 15.1 4.6 0.52 10.9 1.0 2.6 2 0 0 2 2 2 0 MerR, DNA binding PRIMA1 PF16101.5 ORX74957.1 - 0.27 11.3 0.9 0.83 9.7 0.2 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 ELO PF01151.18 ORX74958.1 - 4.1e-57 193.6 19.5 4.9e-57 193.3 19.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CAP PF00188.26 ORX74959.1 - 3.3e-06 27.9 1.5 5.1e-06 27.3 0.1 1.9 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Transferase PF02458.15 ORX74960.1 - 5.4e-15 55.0 0.0 4.1e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 Transferase family Lipase_3 PF01764.25 ORX74963.1 - 4.7e-37 127.0 0.0 6.1e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX74963.1 - 1.1e-06 28.4 0.0 3.2e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Cutinase PF01083.22 ORX74963.1 - 0.00046 20.2 0.0 0.00069 19.6 0.0 1.3 1 0 0 1 1 1 1 Cutinase Hpt PF01627.23 ORX74963.1 - 0.022 15.0 0.0 3.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Hpt domain DUF676 PF05057.14 ORX74963.1 - 0.028 13.9 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 ORX74963.1 - 0.071 12.4 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX74963.1 - 0.11 13.0 0.1 0.24 12.0 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family HPS3_C PF14763.6 ORX74963.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, C-terminal Pkinase PF00069.25 ORX74964.1 - 4.3e-73 245.9 0.0 5.7e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX74964.1 - 5.7e-37 127.4 0.0 8.3e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 ORX74964.1 - 1.7e-13 51.1 0.3 8.3e-13 48.8 0.3 2.1 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 ORX74964.1 - 1.9e-09 37.2 0.0 3.1e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX74964.1 - 0.0034 17.4 0.2 0.047 13.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX74964.1 - 0.0037 16.7 0.0 0.011 15.2 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX74964.1 - 0.013 15.1 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 ORX74964.1 - 0.028 13.4 0.0 0.056 12.4 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Abhydrolase_1 PF00561.20 ORX74965.1 - 1.3e-15 57.7 0.1 1.9e-14 53.9 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX74965.1 - 8.2e-11 41.6 0.3 2.6e-07 30.2 0.3 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX74965.1 - 1.5e-10 42.1 4.4 1.5e-10 42.1 4.4 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 ORX74965.1 - 0.0002 21.6 0.0 0.00035 20.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 ORX74965.1 - 0.023 14.5 0.0 0.066 13.1 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ORX74965.1 - 0.034 14.2 0.0 0.088 12.9 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Ser_hydrolase PF06821.13 ORX74965.1 - 0.045 13.6 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase FSH1 PF03959.13 ORX74965.1 - 0.082 12.6 0.0 0.3 10.7 0.0 1.9 3 0 0 3 3 3 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 ORX74965.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Trypsin PF00089.26 ORX74966.1 - 2.7e-34 118.9 2.2 4.2e-34 118.3 2.2 1.3 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX74966.1 - 0.0057 17.5 0.1 0.011 16.6 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain CDP-OH_P_transf PF01066.21 ORX74967.1 - 3.5e-15 56.5 0.1 3.5e-15 56.5 0.1 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2418 PF10332.9 ORX74967.1 - 3.2 8.3 5.4 1.8 9.2 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2418) Cys_Met_Meta_PP PF01053.20 ORX74968.1 - 9.9e-135 448.9 0.0 1.1e-134 448.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX74968.1 - 0.00056 19.2 0.0 0.00084 18.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX74968.1 - 0.0018 17.6 0.1 0.0073 15.6 0.1 1.9 2 0 0 2 2 2 1 Beta-eliminating lyase SelA PF03841.13 ORX74968.1 - 0.0041 16.2 0.1 0.1 11.6 0.0 2.1 2 0 0 2 2 2 1 L-seryl-tRNA selenium transferase B12-binding PF02310.19 ORX74968.1 - 0.0065 16.5 0.0 1.5 8.9 0.0 2.7 3 0 0 3 3 3 1 B12 binding domain DegT_DnrJ_EryC1 PF01041.17 ORX74968.1 - 0.016 14.6 0.0 0.58 9.4 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aa_trans PF01490.18 ORX74972.1 - 3e-57 194.2 33.3 3.7e-57 193.9 33.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX74972.1 - 6.5e-06 25.2 43.6 2e-05 23.6 43.7 1.7 1 1 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 ORX74972.1 - 0.013 14.6 25.6 0.099 11.7 25.6 2.2 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family DUF2270 PF10028.9 ORX74972.1 - 6.4 6.3 6.6 0.98 9.0 0.1 2.7 3 0 0 3 3 3 0 Predicted integral membrane protein (DUF2270) Glyoxalase_3 PF13468.6 ORX74973.1 - 0.046 13.8 0.4 0.059 13.5 0.4 1.1 1 0 0 1 1 1 0 Glyoxalase-like domain Abi_C PF14355.6 ORX74973.1 - 0.095 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Abortive infection C-terminus STAT_alpha PF01017.20 ORX74973.1 - 1.8 8.5 7.9 3.3 7.6 6.0 1.9 1 1 1 2 2 2 0 STAT protein, all-alpha domain HLH PF00010.26 ORX74974.1 - 3e-14 52.7 1.5 5.3e-14 51.9 1.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pkinase_fungal PF17667.1 ORX74976.1 - 0.004 16.0 0.0 0.014 14.2 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Chromo_shadow PF01393.19 ORX74977.1 - 5.6e-14 52.0 0.2 2.2e-10 40.4 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 ORX74977.1 - 3.4e-09 36.5 3.2 9.6e-09 35.0 3.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Hamartin PF04388.12 ORX74977.1 - 0.12 11.0 2.9 0.13 10.9 2.9 1.0 1 0 0 1 1 1 0 Hamartin protein zf-C2H2 PF00096.26 ORX74978.1 - 1.3e-09 38.0 11.9 2e-05 24.8 1.9 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 ORX74978.1 - 7.5e-07 29.7 0.8 0.0033 18.0 0.1 2.0 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX74978.1 - 4.3e-06 27.1 8.5 0.0073 17.1 0.9 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX74978.1 - 0.00024 21.3 0.6 0.0012 19.1 0.6 1.8 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 ORX74978.1 - 0.00034 20.9 16.9 0.00041 20.6 3.4 3.2 3 0 0 3 3 3 1 Zinc-finger double domain CHORD PF04968.12 ORX74978.1 - 0.037 14.8 4.8 1.5 9.6 0.2 2.1 1 1 1 2 2 2 0 CHORD zf-met PF12874.7 ORX74978.1 - 0.047 14.1 2.9 6.1 7.4 0.1 2.8 2 1 1 3 3 3 0 Zinc-finger of C2H2 type RPAP2_Rtr1 PF04181.13 ORX74978.1 - 0.056 13.8 2.1 0.86 10.0 2.1 2.0 1 1 0 1 1 1 0 Rtr1/RPAP2 family zf-C2H2_6 PF13912.6 ORX74978.1 - 0.23 11.5 0.1 0.23 11.5 0.1 3.2 3 1 0 3 3 3 0 C2H2-type zinc finger MFS_1 PF07690.16 ORX74980.1 - 1.9e-44 152.1 35.9 1.9e-44 152.1 35.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX74980.1 - 9.7e-13 47.8 10.8 9.7e-13 47.8 10.8 3.3 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX74981.1 - 2.6e-46 158.2 42.3 2.6e-46 158.2 42.3 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX74981.1 - 9.7e-18 63.9 22.9 1.3e-17 63.5 22.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX74981.1 - 2.6e-14 52.9 25.9 3.4e-12 46.0 8.6 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2358 PF10184.9 ORX74982.1 - 3.8e-06 27.1 0.0 7.1e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2358) Mito_carr PF00153.27 ORX74983.1 - 5.7e-28 96.7 2.2 6.4e-14 51.7 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein GTP_EFTU PF00009.27 ORX74985.1 - 8.3e-57 191.9 0.3 1.6e-56 190.9 0.2 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX74985.1 - 1.5e-29 102.5 0.0 3e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX74985.1 - 1.4e-15 57.4 1.0 3.5e-15 56.1 1.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX74985.1 - 1.6e-05 25.0 0.1 2.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX74985.1 - 0.0026 17.7 0.2 0.0081 16.1 0.1 1.7 1 1 0 1 1 1 1 RsgA GTPase cobW PF02492.19 ORX74985.1 - 0.015 14.9 1.1 0.019 14.6 0.1 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ORX74985.1 - 0.079 12.7 0.4 16 5.2 0.1 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FF PF01846.19 ORX74986.1 - 2.6e-15 56.3 1.8 2e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 FF domain WW PF00397.26 ORX74986.1 - 1.1e-09 38.2 4.4 8.7e-08 32.1 0.7 2.5 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 ORX74986.1 - 0.0069 16.7 0.3 0.98 9.7 0.1 2.6 2 0 0 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain AAA PF00004.29 ORX74987.1 - 2.7e-43 147.5 0.0 4.7e-43 146.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX74987.1 - 3.9e-11 42.6 0.2 8.6e-11 41.5 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ORX74987.1 - 9.2e-11 41.5 0.6 2.3e-10 40.3 0.0 2.0 3 0 0 3 3 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 ORX74987.1 - 1.5e-07 32.0 0.1 9.2e-05 22.9 0.0 3.1 3 1 1 4 4 3 1 AAA ATPase domain AAA_5 PF07728.14 ORX74987.1 - 1.1e-06 28.8 0.2 1.7e-05 24.8 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX74987.1 - 3.7e-06 27.2 0.0 1.1e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX74987.1 - 6.3e-06 26.0 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 ORX74987.1 - 0.00012 21.4 0.0 0.00028 20.1 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ORX74987.1 - 0.0002 21.7 0.1 0.0027 18.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX74987.1 - 0.00023 21.7 0.0 0.00069 20.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX74987.1 - 0.00082 18.9 0.0 0.0018 17.8 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 ORX74987.1 - 0.0018 17.6 0.0 0.0031 16.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 ORX74987.1 - 0.0019 18.6 0.0 0.0056 17.1 0.0 1.8 2 0 0 2 2 1 1 RNA helicase Mg_chelatase PF01078.21 ORX74987.1 - 0.0029 17.0 0.0 0.0053 16.2 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ORX74987.1 - 0.0043 17.0 0.0 0.0081 16.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ORX74987.1 - 0.0057 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 ORX74987.1 - 0.0068 16.6 0.0 0.021 15.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ORX74987.1 - 0.0076 16.1 0.0 0.023 14.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX74987.1 - 0.0078 16.3 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX74987.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX74987.1 - 0.011 15.5 0.0 0.032 13.9 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 ORX74987.1 - 0.029 14.1 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 ORX74987.1 - 0.03 14.0 0.1 0.15 11.7 0.0 2.1 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain Parvo_NS1 PF01057.17 ORX74987.1 - 0.037 13.1 0.0 0.069 12.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 ORX74987.1 - 0.048 13.6 0.0 0.16 11.9 0.0 1.9 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 ORX74987.1 - 0.085 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ORX74987.1 - 0.089 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 ORX74987.1 - 0.091 12.0 0.1 0.2 10.9 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 ORX74987.1 - 0.096 11.9 0.1 0.27 10.4 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain ATPase PF06745.13 ORX74987.1 - 0.1 12.0 0.0 0.39 10.0 0.0 1.9 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 ORX74987.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ORX74987.1 - 0.14 11.7 0.0 0.38 10.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ORX74987.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Myb_DNA-bind_4 PF13837.6 ORX74989.1 - 0.066 13.6 0.8 0.15 12.5 0.8 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 ORX74989.1 - 0.082 13.6 0.3 0.24 12.1 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF573 DUF1459 PF07312.11 ORX74990.1 - 3 8.1 15.1 2.5 8.4 9.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1459) Ribosomal_S7e PF01251.18 ORX74993.1 - 7.5e-80 267.0 4.8 8.5e-80 266.9 4.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Autophagy_act_C PF03987.15 ORX74994.1 - 1.9e-11 44.3 0.0 7.3e-11 42.5 0.0 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain BOFC_N PF08977.10 ORX74994.1 - 0.076 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Bypass of Forespore C, N terminal PAP2_C PF14360.6 ORX74995.1 - 3.3e-20 72.4 5.2 3.3e-20 72.4 5.2 2.0 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ORX74995.1 - 1.2e-07 31.6 11.3 2e-07 30.8 11.3 1.3 1 0 0 1 1 1 1 PAP2 superfamily Peptidase_U4 PF03419.13 ORX74995.1 - 9.6 5.4 7.5 14 4.8 7.5 1.4 1 1 0 1 1 1 0 Sporulation factor SpoIIGA SE PF08491.10 ORX74996.1 - 2.1e-68 230.3 0.0 3.7e-61 206.6 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase DAO PF01266.24 ORX74996.1 - 0.0021 17.7 0.0 0.0065 16.1 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX74996.1 - 0.0039 17.4 0.0 0.0092 16.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX74996.1 - 0.012 14.9 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 ORX74996.1 - 0.023 13.7 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 ORX74996.1 - 0.11 11.7 0.2 4.6 6.4 0.0 2.8 2 1 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 ORX74996.1 - 0.19 10.9 0.0 0.41 9.8 0.0 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ArsA_ATPase PF02374.15 ORX74996.1 - 0.25 10.5 0.0 0.37 9.9 0.0 1.1 1 0 0 1 1 1 0 Anion-transporting ATPase DUF1729 PF08354.10 ORX74997.1 - 3e-108 361.9 0.1 5e-107 357.9 0.1 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1729) Fas_alpha_ACP PF18325.1 ORX74997.1 - 5.7e-49 166.6 0.0 1.2e-48 165.6 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain MaoC_dehydratas PF01575.19 ORX74997.1 - 7e-29 99.9 0.1 1.5e-28 98.8 0.1 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_I_H PF18314.1 ORX74997.1 - 8.5e-28 97.4 0.3 2e-26 92.9 0.3 2.4 1 1 0 1 1 1 1 Fatty acid synthase type I helical domain Acyl_transf_1 PF00698.21 ORX74997.1 - 3.1e-15 56.5 0.1 6.1e-14 52.2 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain FAS_meander PF17951.1 ORX74997.1 - 5.3e-08 32.8 0.8 0.00079 19.3 0.1 2.9 2 1 1 3 3 3 2 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX74997.1 - 1.8e-07 31.2 0.0 3e-05 23.9 0.0 2.6 1 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 ORX74997.1 - 3.3e-05 23.6 0.0 0.014 15.0 0.0 2.6 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain adh_short PF00106.25 ORX74997.1 - 0.0005 19.6 0.0 0.0012 18.4 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX74997.1 - 0.065 13.1 0.0 0.24 11.3 0.0 2.0 1 0 0 1 1 1 0 KR domain Ketoacyl-synt_C PF02801.22 ORX74997.1 - 0.096 12.7 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain GDP_Man_Dehyd PF16363.5 ORX74997.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AMP-binding PF00501.28 ORX74998.1 - 1.1e-68 231.8 0.0 8.8e-68 228.8 0.0 2.1 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX74998.1 - 7.4e-14 52.5 0.0 6.3e-13 49.5 0.1 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Aa_trans PF01490.18 ORX74999.1 - 6.5e-60 202.9 29.1 8.1e-60 202.6 29.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX74999.1 - 3e-05 23.0 36.9 5.5e-05 22.2 36.9 1.4 1 1 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 ORX74999.1 - 0.0004 19.6 13.1 0.0004 19.6 13.1 2.0 1 1 1 3 3 3 1 Tryptophan/tyrosine permease family PepSY_TM PF03929.16 ORX74999.1 - 0.016 14.9 0.8 0.17 11.6 0.1 2.4 2 0 0 2 2 2 0 PepSY-associated TM region DUF373 PF04123.13 ORX74999.1 - 0.84 9.0 9.4 0.058 12.8 2.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF373) CoA_binding PF02629.19 ORX75000.1 - 1.3e-14 54.6 2.1 3.1e-14 53.4 0.3 2.2 2 1 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 ORX75000.1 - 6.3e-08 32.6 0.3 2.5e-07 30.6 0.1 1.9 2 0 0 2 2 2 1 CoA-ligase Succ_CoA_lig PF13607.6 ORX75000.1 - 0.00019 21.3 0.0 0.00078 19.3 0.0 2.1 3 0 0 3 3 3 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 ORX75000.1 - 0.00043 20.7 0.1 0.0013 19.2 0.1 1.8 2 0 0 2 2 2 1 CoA binding domain CBFD_NFYB_HMF PF00808.23 ORX75001.1 - 1.8e-18 66.5 0.5 4.2e-18 65.4 0.5 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX75001.1 - 3.8e-15 56.4 0.1 3.8e-15 56.4 0.1 2.2 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 ORX75001.1 - 0.012 16.0 0.1 0.026 14.8 0.1 1.5 1 0 0 1 1 1 0 CENP-S associating Centromere protein X SHE3 PF17078.5 ORX75002.1 - 0.00055 19.7 4.0 0.001 18.9 4.0 1.5 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 TBCA PF02970.16 ORX75003.1 - 1.3e-23 83.2 4.2 1.4e-23 83.0 4.2 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A IMD PF08397.11 ORX75003.1 - 0.011 15.2 1.1 0.011 15.2 1.1 1.0 1 0 0 1 1 1 0 IRSp53/MIM homology domain Cytotoxic PF09000.10 ORX75003.1 - 0.036 14.4 0.0 0.039 14.3 0.0 1.2 1 0 0 1 1 1 0 Cytotoxic Pkinase PF00069.25 ORX75004.1 - 1e-63 215.2 0.0 1.6e-63 214.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX75004.1 - 2.6e-37 128.5 0.0 4.2e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX75004.1 - 0.0005 19.0 0.9 0.00068 18.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX75004.1 - 0.00077 18.9 0.1 0.0018 17.7 0.1 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX75004.1 - 0.0057 16.6 0.2 0.032 14.1 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX75004.1 - 0.022 14.1 0.1 0.065 12.6 0.1 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribonuclease_T2 PF00445.18 ORX75005.1 - 7.2e-36 124.1 6.3 1.1e-35 123.6 6.3 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family PPP5 PF08321.12 ORX75005.1 - 0.013 15.8 0.2 3.4 8.0 0.0 2.3 1 1 1 2 2 2 0 PPP5 TPR repeat region Lipase_GDSL_2 PF13472.6 ORX75006.1 - 4.4e-06 27.2 2.2 6.9e-06 26.6 2.2 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX75006.1 - 2.3e-05 24.5 0.3 3.2e-05 24.0 0.3 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase zf-C2H2 PF00096.26 ORX75007.1 - 2.1e-18 65.6 17.1 1.8e-06 28.1 1.4 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX75007.1 - 5.8e-14 51.6 13.9 0.00011 22.8 2.5 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX75007.1 - 1.6e-10 40.9 10.3 0.00074 19.8 2.4 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX75007.1 - 2.6e-08 33.6 9.6 5.5e-05 23.1 0.4 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 ORX75007.1 - 4.4e-06 26.9 6.1 0.0066 16.8 0.1 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX75007.1 - 6.9e-06 26.2 10.4 0.00043 20.5 0.3 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX75007.1 - 1.2e-05 24.9 7.2 0.21 11.4 0.6 3.1 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 ORX75007.1 - 0.00044 20.5 5.6 0.0007 19.8 5.5 1.4 1 1 0 1 1 1 1 C2H2-type zinc ribbon Zn_Tnp_IS1595 PF12760.7 ORX75007.1 - 0.011 15.7 7.7 0.011 15.7 7.7 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf_UBZ PF18439.1 ORX75007.1 - 0.012 15.2 6.4 2.3 7.9 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 ORX75007.1 - 0.061 13.6 11.5 0.63 10.3 4.1 3.0 1 1 1 2 2 2 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 ORX75007.1 - 0.071 13.9 3.2 0.15 12.8 3.2 1.6 1 1 0 1 1 1 0 zinc-ribbon family zf-C2H2_2 PF12756.7 ORX75007.1 - 0.098 13.0 8.3 5.6 7.4 0.8 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc-ribbons_6 PF07191.12 ORX75007.1 - 0.11 12.5 7.1 0.79 9.7 3.0 2.6 1 1 0 2 2 2 0 zinc-ribbons Zn_ribbon_recom PF13408.6 ORX75007.1 - 0.18 12.4 2.5 0.19 12.3 0.8 1.8 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 ORX75007.1 - 0.18 12.1 9.1 0.17 12.2 5.5 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.6 ORX75007.1 - 0.2 11.7 7.6 6.2 6.9 0.5 3.0 1 1 2 3 3 3 0 CpXC protein zf_ZIC PF18366.1 ORX75007.1 - 0.2 11.8 4.5 7.9 6.7 0.6 2.5 2 1 0 2 2 2 0 Zic proteins zinc finger domain Zn-ribbon_8 PF09723.10 ORX75007.1 - 0.22 11.7 8.0 3.4 7.9 3.3 2.8 2 1 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.13 ORX75007.1 - 0.28 11.3 6.6 0.65 10.1 2.1 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 ORX75007.1 - 0.31 11.2 16.5 0.14 12.4 2.3 3.3 2 2 1 3 3 3 0 AN1-like Zinc finger HypA PF01155.19 ORX75007.1 - 0.55 10.3 3.6 1.2 9.2 0.5 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 ORX75007.1 - 5.6 7.0 10.3 40 4.2 6.6 3.0 2 1 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 ORX75007.1 - 8.5 6.4 12.3 0.95 9.4 6.3 2.2 2 1 0 2 2 2 0 SprT-like zinc ribbon domain OrfB_Zn_ribbon PF07282.11 ORX75007.1 - 9.1 6.3 10.3 6.9 6.7 0.3 3.0 2 1 1 3 3 3 0 Putative transposase DNA-binding domain RNA_pol_A_bac PF01000.26 ORX75008.1 - 8.7e-35 119.5 0.2 1.9e-34 118.4 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ORX75008.1 - 8.5e-20 70.0 0.0 1.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SRF-TF PF00319.18 ORX75009.1 - 1.2e-21 75.9 0.1 1.3e-21 75.8 0.1 1.1 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF2721 PF11026.8 ORX75009.1 - 0.052 13.4 0.1 0.058 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Mitoc_mL59 PF18126.1 ORX75010.1 - 7.2e-17 61.9 6.1 6.3e-16 58.9 6.1 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Clathrin_lg_ch PF01086.17 ORX75010.1 - 0.011 15.8 1.0 0.013 15.5 1.0 1.1 1 0 0 1 1 1 0 Clathrin light chain Dec-1 PF04624.14 ORX75010.1 - 0.39 10.6 3.3 3 7.8 0.6 2.3 1 1 1 2 2 2 0 Dec-1 repeat HTH_Tnp_ISL3 PF13542.6 ORX75011.1 - 0.071 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HD-ZIP_N PF04618.12 ORX75011.1 - 0.58 10.7 7.5 0.087 13.3 2.1 2.4 3 0 0 3 3 3 0 HD-ZIP protein N terminus ABC_tran PF00005.27 ORX75012.1 - 1e-45 155.6 0.0 1.1e-25 90.7 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX75012.1 - 5.7e-15 55.3 1.1 0.00097 18.6 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX75012.1 - 3.8e-07 29.8 0.1 0.013 15.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX75012.1 - 1.2e-06 28.6 0.4 0.081 13.0 0.1 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX75012.1 - 6.9e-06 26.1 0.0 0.065 13.1 0.0 3.5 3 1 0 3 3 3 2 RsgA GTPase Dynamin_N PF00350.23 ORX75012.1 - 0.00031 20.8 0.7 0.1 12.7 0.1 2.6 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 ORX75012.1 - 0.00042 20.7 0.0 1.2 9.5 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.17 ORX75012.1 - 0.00048 19.9 0.1 0.17 11.6 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein DUF87 PF01935.17 ORX75012.1 - 0.0024 18.0 0.5 0.42 10.7 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 ORX75012.1 - 0.0028 18.0 0.5 2.3 8.5 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX75012.1 - 0.0029 17.1 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_21 PF13304.6 ORX75012.1 - 0.0033 17.3 2.3 0.057 13.2 0.1 2.9 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 ORX75012.1 - 0.0044 16.3 2.1 9.5 5.3 0.1 4.0 4 0 0 4 4 4 0 NB-ARC domain AAA_15 PF13175.6 ORX75012.1 - 0.0055 16.5 0.1 0.74 9.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 ORX75012.1 - 0.0062 16.1 3.7 0.61 9.6 0.0 3.5 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.6 ORX75012.1 - 0.0063 17.0 0.0 0.99 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain CBFD_NFYB_HMF PF00808.23 ORX75012.1 - 0.0083 16.4 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone T2SSE PF00437.20 ORX75012.1 - 0.018 14.1 0.0 2.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 ORX75012.1 - 0.02 15.1 0.6 14 5.9 0.1 3.4 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 ORX75012.1 - 0.025 14.2 0.0 0.38 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX75012.1 - 0.027 14.8 0.0 16 5.9 0.0 3.5 4 0 0 4 4 3 0 RNA helicase FtsK_SpoIIIE PF01580.18 ORX75012.1 - 0.029 13.7 0.0 8.6 5.6 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 ORX75012.1 - 0.04 13.6 1.2 2.7 7.7 0.0 3.0 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 ORX75012.1 - 0.055 13.1 0.3 0.75 9.4 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ORX75012.1 - 0.061 13.9 0.4 3 8.4 0.1 3.1 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ORX75012.1 - 0.064 13.7 0.0 11 6.5 0.0 3.0 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ORX75012.1 - 0.065 12.5 0.2 9.1 5.5 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin F-box-like PF12937.7 ORX75018.1 - 0.02 14.8 0.0 0.065 13.1 0.0 2.0 2 0 0 2 2 2 0 F-box-like Trp_halogenase PF04820.14 ORX75018.1 - 0.16 10.8 0.0 0.94 8.3 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase Glyco_transf_22 PF03901.17 ORX75019.1 - 1.6e-73 248.4 12.0 9.1e-73 245.9 12.0 1.8 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family MadM PF03818.13 ORX75019.1 - 0.16 11.9 4.6 4.8 7.1 1.2 2.7 2 0 0 2 2 2 0 Malonate/sodium symporter MadM subunit CwsA PF10814.8 ORX75019.1 - 5.3 7.2 5.3 3.3 7.9 1.2 2.3 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA CBS PF00571.28 ORX75020.1 - 1.3e-23 83.2 0.2 1.2e-06 28.8 0.0 4.1 4 0 0 4 4 4 4 CBS domain Ras PF00071.22 ORX75021.1 - 2.9e-44 150.5 0.7 3.4e-44 150.3 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX75021.1 - 1.6e-13 50.9 0.0 2.4e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX75021.1 - 1e-09 38.1 0.1 1.2e-09 37.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX75021.1 - 2.4e-08 34.1 0.2 5.4e-06 26.4 0.2 2.2 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX75021.1 - 1.3e-05 24.9 0.5 4.4e-05 23.1 0.5 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX75021.1 - 3.8e-05 23.3 0.1 0.00019 21.0 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ORX75021.1 - 0.0024 17.3 0.1 0.0034 16.9 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX75021.1 - 0.0066 16.5 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX75021.1 - 0.015 15.7 0.0 0.017 15.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ORX75021.1 - 0.05 13.6 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF3721 PF12518.8 ORX75021.1 - 0.056 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function Viral_helicase1 PF01443.18 ORX75021.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Pkinase PF00069.25 ORX75022.1 - 1.6e-56 191.6 0.0 2.2e-56 191.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX75022.1 - 1.4e-42 145.8 0.0 2.2e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX75022.1 - 2e-08 33.9 0.0 3.2e-05 23.4 0.0 2.4 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ORX75022.1 - 2.8e-07 29.7 0.0 4.3e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX75022.1 - 0.002 17.5 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX75022.1 - 0.069 12.1 0.0 1.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 ORX75022.1 - 0.13 12.1 1.5 0.34 10.8 0.0 2.4 3 1 1 4 4 4 0 Phosphotransferase enzyme family Trp_oprn_chp PF09534.10 ORX75025.1 - 2.5 7.9 25.8 2.8 7.7 25.8 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4191 PF13829.6 ORX75025.1 - 2.7 7.3 6.5 3.2 7.0 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) SUR7 PF06687.12 ORX75025.1 - 7.7 6.1 11.9 9 5.9 11.9 1.1 1 0 0 1 1 1 0 SUR7/PalI family PQ-loop PF04193.14 ORX75027.1 - 1.5e-35 120.8 8.5 1.5e-17 63.1 1.2 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 ORX75027.1 - 0.17 11.9 0.3 0.17 11.9 0.3 2.8 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange ECF_trnsprt PF12822.7 ORX75027.1 - 2.3 8.3 13.7 0.077 13.1 6.1 2.1 1 1 1 2 2 2 0 ECF transporter, substrate-specific component Myb_DNA-binding PF00249.31 ORX75028.1 - 1.5e-05 25.1 0.0 3.2e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Rhodanese PF00581.20 ORX75029.1 - 4.8e-07 30.3 0.2 1e-06 29.2 0.2 1.6 1 1 0 1 1 1 1 Rhodanese-like domain zf-H2C2_2 PF13465.6 ORX75030.1 - 7.8e-05 22.9 7.6 0.00032 21.0 3.6 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 ORX75030.1 - 0.0098 16.3 3.4 0.0098 16.3 3.4 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ORX75030.1 - 0.043 14.1 0.1 0.052 13.8 0.1 1.3 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ORX75030.1 - 0.21 12.5 1.7 0.21 12.5 1.7 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger DUF1640 PF07798.11 ORX75032.1 - 3.9e-15 56.3 2.5 5e-15 56.0 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) Terminase_1 PF03354.15 ORX75032.1 - 0.022 13.3 0.5 0.028 13.0 0.5 1.1 1 0 0 1 1 1 0 Phage Terminase DUF1640 PF07798.11 ORX75033.1 - 5.7e-07 29.7 0.1 7.5e-07 29.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DUF5329 PF17263.2 ORX75033.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5329) MAP17 PF15807.5 ORX75033.1 - 0.16 12.2 0.1 0.42 10.8 0.1 1.6 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GA PF01468.17 ORX75034.1 - 0.032 14.5 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 GA module DUF924 PF06041.11 ORX75034.1 - 0.12 12.5 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) Ribosomal_S9 PF00380.19 ORX75036.1 - 3.8e-21 75.9 0.0 1.6e-20 73.9 0.0 2.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Utp12 PF04003.12 ORX75036.1 - 2.6e-20 72.7 0.5 5.3e-20 71.7 0.5 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 ORX75036.1 - 0.014 16.3 0.9 50 5.0 0.0 4.1 3 0 0 3 3 3 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX75036.1 - 0.017 15.4 0.1 1.3 9.4 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BUD22 PF09073.10 ORX75036.1 - 1.7 7.9 30.3 0.0096 15.3 13.8 3.0 3 0 0 3 3 3 0 BUD22 p450 PF00067.22 ORX75037.1 - 2.6e-60 204.5 0.0 3.6e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ribonuclease_T2 PF00445.18 ORX75038.1 - 1.9e-33 116.2 6.0 2.6e-33 115.8 6.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family DUF5538 PF17692.1 ORX75038.1 - 0.0074 16.3 2.2 0.012 15.7 2.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5538) PPP5 PF08321.12 ORX75038.1 - 0.011 16.0 0.2 2.9 8.2 0.1 2.3 1 1 1 2 2 2 0 PPP5 TPR repeat region Ubiquitin_4 PF18036.1 ORX75038.1 - 0.06 13.4 0.1 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-like domain AAA PF00004.29 ORX75039.1 - 3.9e-30 105.0 0.0 9e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX75039.1 - 2.7e-10 39.9 0.1 7.8e-09 35.2 0.1 2.5 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ORX75039.1 - 8.2e-08 32.1 0.0 3e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 ORX75039.1 - 1.8e-07 31.1 0.0 3.8e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX75039.1 - 0.00016 22.1 2.4 0.01 16.3 2.4 3.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX75039.1 - 0.00021 21.6 1.6 0.087 13.1 0.1 2.9 1 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 ORX75039.1 - 0.00047 20.2 1.5 0.22 11.5 0.1 2.9 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ORX75039.1 - 0.029 13.8 2.1 0.092 12.1 1.1 2.3 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 ORX75039.1 - 0.041 13.3 0.1 5.4 6.4 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein TIP49 PF06068.13 ORX75039.1 - 0.08 12.1 0.0 0.18 11.0 0.0 1.5 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_21 PF13304.6 ORX75039.1 - 0.1 12.4 0.1 1.5 8.6 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase PF06745.13 ORX75039.1 - 0.14 11.5 0.1 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 ORX75039.1 - 0.14 11.9 0.2 0.32 10.7 0.2 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX75039.1 - 0.19 12.1 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase GDI PF00996.18 ORX75040.1 - 3.6e-192 638.7 1.2 3.3e-128 427.9 0.1 2.0 1 1 1 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 ORX75040.1 - 0.063 13.5 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SAPS PF04499.15 ORX75041.1 - 4.6e-98 329.1 6.2 2.3e-55 188.3 0.0 4.0 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein INTAP PF16617.5 ORX75041.1 - 9.2 6.7 11.5 0.35 11.2 4.7 2.2 2 0 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region His_Phos_2 PF00328.22 ORX75042.1 - 1.2e-09 38.1 0.0 2e-09 37.3 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Rz1 PF06085.11 ORX75042.1 - 0.049 13.4 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 Lipoprotein Rz1 precursor His_Phos_2 PF00328.22 ORX75043.1 - 3.7e-05 23.3 0.0 4.6e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NPP1 PF05630.11 ORX75043.1 - 0.14 12.2 0.2 0.22 11.6 0.2 1.2 1 0 0 1 1 1 0 Necrosis inducing protein (NPP1) DUF1729 PF08354.10 ORX75044.1 - 1.5e-77 260.9 0.0 3e-77 259.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX75044.1 - 1.3e-26 93.9 0.2 2.4e-25 89.7 0.1 2.8 3 0 0 3 3 3 1 Acyl transferase domain FAS_I_H PF18314.1 ORX75044.1 - 1.4e-18 67.3 0.8 3.1e-18 66.2 0.2 1.8 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain MaoC_dehydratas PF01575.19 ORX75044.1 - 1.4e-18 66.6 0.0 3.7e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain FAS_meander PF17951.1 ORX75044.1 - 2.2e-16 60.0 0.0 3.2e-15 56.2 0.0 2.5 1 1 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ABC_membrane PF00664.23 ORX75045.1 - 3.3e-21 76.2 2.0 4.3e-21 75.8 2.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region HBD PF18534.1 ORX75045.1 - 0.043 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Helical bundle domain ABC_tran PF00005.27 ORX75046.1 - 4.2e-29 101.8 0.0 7.1e-29 101.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX75046.1 - 4.9e-07 29.7 0.2 7.1e-07 29.2 0.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX75046.1 - 1.7e-05 24.4 0.4 0.0007 19.1 0.0 2.8 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ORX75046.1 - 0.0028 16.8 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ORX75046.1 - 0.0095 16.2 0.1 2.2 8.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX75046.1 - 0.011 16.2 0.2 0.038 14.4 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ORX75046.1 - 0.018 14.6 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ORX75046.1 - 0.06 13.4 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX75046.1 - 0.09 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX75046.1 - 0.11 12.3 1.6 7.4 6.3 0.3 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Linderina_pennispora_ATCC_12442-Linpe1/GCA_002104995.1_Linpe1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Linderina_pennispora_ATCC_12442-Linpe1/GCA_002104995.1_Linpe1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Linderina_pennispora_ATCC_12442-Linpe1/GCA_002104995.1_Linpe1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Linderina_pennispora_ATCC_12442-Linpe1/GCA_002104995.1_Linpe1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 22:55:23 2019 # [ok]